bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Tropical Cyclones on the Total Precipitation in Cuba during the Hurricane Season from 1980 to 2016
Authors: Fernández–Alvarez José C. , Sorí Rogert , Pérez–Alarcón Albenis , Nieto Raquel , Gimeno Luis
Published: October 2020

This study quantifies the amount of rainfall supplied by tropical cyclones (TCs) to Cuba. It uses the long–term global gridded Multi–Source Weighted–Ensemble Precipitation (MSWEP) v2 data set, with a resolution of 0.1° in latitude and longitude, and a temporal resolution of 3 h during the hurricane seasons from 1980–2016. During this study period, 146 TCs were identified within a 500–km radius of Cuba. The contribution of TCs to the total precipitation over Cuba during the cyclonic season was ~11%. The maximum contribution occurs in October and November, representing 18% and 28% of the total precipitation, respectively. The interannual precipitation contribution shows a positive correlation (~0.74) with the number of TCs, but without a significant trend for the period. A climatological spatial analysis of the rainfall associated with TCs revealed great heterogeneity, although the major contribution was observed along the southern coast of the eastern and central provinces of Cuba, and in the western province of Pinar del Río. No significant difference was observed between the number of TCs that affected Cuba and their rainfall contribution under the positive and negative phases of the El Niño Southern Oscillation. However, the negative phase of the NAO led to an increase in the genesis of TCs that later affected Cuba, which led to a greater contribution to precipitation compared to that obtained from TCs during the positive phase of this oscillation. Our results also confirm that anomalous warmth of the tropical Atlantic Ocean, revealed through the Atlantic Meridional Mode, and enlargement of the Atlantic Warm Pool, enhances the genesis in the North Atlantic Basin of the TCs that affect Cuba, which was associated with an increase of the rainfall contribution to the total precipitation compared to that calculated for TCs formed during the opposite phases.
Precipitation Nowcasting with Weather Radar Images and Deep Learning in São Paulo, Brasil
Authors: Bonnet Suzanna Maria , Evsukoff Alexandre , Morales Rodriguez Carlos Augusto
Published: October 2020

Precipitation nowcasting can predict and alert for any possibility of abrupt weather changes which may cause both human and material risks. Most of the conventional nowcasting methods extrapolate weather radar echoes, but precipitation nowcasting is still a challenge, mainly due to rapid changes in meteorological systems and time required for numerical simulations. Recently video prediction deep learning (VPDL) algorithms have been applied in precipitation nowcasting. In this study, we use the VPDL PredRNN++ and sequences of radar reflectivity images to predict the future sequence of reflectivity images for up to 1-h lead time for São Paulo, Brazil. We also verify the feasibility for the continuous use of the VPDL model, providing the meteorologist with trends and forecasts in precipitation edges regardless of the weather event occurring. The results obtained confirm the potential of the VPDL model as an additional tool to assist nowcasting. Even though meteorological systems that trigger natural disasters vary by location, a general solution can contribute as a tool to assist decision-makers and consequently issue efficient alerts.
Tongqiaohuoxue Hinders Development and Progression of Atherosclerosis: A Possible Role in Alzheimer’s Disease
Authors: Ha Eunyoung , Kim Mikyung , Chun Jaemoo , Seo Chang-Seob , Ahn YouMee , Jung Jeeyoun
Published: October 2020

Atherosclerosis is closely associated with Alzheimer’s disease (AD). Tongqiaohuoxue decoction (THD) is a classical herbal prescription in traditional Chinese medicine widely used for the prevention and treatment of cerebrovascular disease. This study aimed to explore the therapeutic effects of THD on atherosclerosis and AD. Eight-week-old C57BL6/J wild-type and ApoE-deficient (ApoE-/-) mice were fed a high-fat and high-cholesterol diet for eight weeks, followed by oral phosphate-buffered saline vehicle or THD treatment for eight weeks further. In ApoE-/- mice, THD attenuated lipid deposition in the aorta and the brain, and abrogated atherosclerotic changes without affecting serum lipid profiles while decreasing amyloid plaque formation. In vitro assays undertaken to understand THD’s effects on lipid clearance in the aorta and brain vessels revealed that THD treatment inhibited the lipid uptake, stimulated by oxidized low-density lipoprotein, resulted in decreased endothelial cell activation through reduction in intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and monocyte chemoattractant protein-1 levels. Serum analysis revealed inhibitory effects of THD on resistin production, which has important roles in the development of both atherosclerosis and AD. In conclusion, the current study demonstrates beneficial effects of THD on the development and progression of atherosclerosis, and a possible protective role against AD.
Luteolin Induces Selective Cell Death of Human Pluripotent Stem Cells
Authors: Go Young-Hyun , Kim Jumee , Jeong Ho-Chang , Kim Seong-Min , Kim Yun-Jeong , Park Soon-Jung , Moon Sung-Hwan , Cha Hyuk-Jin
Published: October 2020

Despite recent advances in clinical stem cell therapy applications based on human pluripotent stem cells (hPSCs), potential teratoma formation due to the presence of residual undifferentiated hPSCs remains a serious risk factor that challenges widespread clinical application. To overcome this risk, a variety of approaches have been developed to eliminate the remaining undifferentiated hPSCs via selective cell death induction. Our study seeks to identify natural flavonoids that are more potent than quercetin (QC), to selectively induce hPSC death. Upon screening in-house flavonoids, luteolin (LUT) is found to be more potent than QC to eliminate hPSCs in a p53-dependent manner, but not hPSC-derived smooth muscle cells or perivascular progenitor cells. Particularly, treating human embryonic stem cell (hESC)-derived cardiomyocytes with LUT efficiently eliminates the residual hESCs and only results in marginal effects on cardiomyocyte (CM) functions, as determined by calcium influx. Considering the technical limitations of isolating CMs due to a lack of exclusive surface markers at the end of differentiation, LUT treatment is a promising approach to minimize teratoma formation risk.
Biosensors for Detecting Lymphocytes and Immunoglobulins
Authors: Salvo Pietro , Vivaldi Federico M. , Bonini Andrea , Biagini Denise , Bellagambi Francesca G. , Miliani Filippo M. , Di Francesco Fabio , Lomonaco Tommaso
Published: October 2020

Lymphocytes (B, T and natural killer cells) and immunoglobulins are essential for the adaptive immune response against external pathogens. Flow cytometry and enzyme-linked immunosorbent (ELISA) kits are the gold standards to detect immunoglobulins, B cells and T cells, whereas the impedance measurement is the most used technique for natural killer cells. For point-of-care, fast and low-cost devices, biosensors could be suitable for the reliable, stable and reproducible detection of immunoglobulins and lymphocytes. In the literature, such biosensors are commonly fabricated using antibodies, aptamers, proteins and nanomaterials, whereas electrochemical, optical and piezoelectric techniques are used for detection. This review describes how these measurement techniques and transducers can be used to fabricate biosensors for detecting lymphocytes and the total content of immunoglobulins. The various methods and configurations are reported, along with the advantages and current limitations.
Rare VPS35 A320V Variant in Taiwanese Parkinson’s Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology
Authors: Wu Yih-Ru , Lin Chih-Hsin , Chao Chih-Ying , Chang Chia-Wen , Chen Chiung-Mei , Lee-Chen Guey-Jen
Published: October 2020

Sequence variants in vacuolar protein sorting 35 (VPS35) have been reported to be associated with Parkinson’s disease (PD). To investigate if the genetic variants in VPS35 contribute to Taiwanese PD, VPS35 cDNA fragments from 62 patients with PD were sequenced. A cohort of PD (n = 560) and ethnically matched controls (n = 506) were further examined for the identified mutation. The effects of the mutation on cation-independent mannose-6-phosphate receptor (CI-MPR) sorting and mitochondrial morphology were further examined in 293T cells expressing the mutant VPS35. Here, a novel heterozygous A320V in the VPS35 gene was identified in two late-onset PD (LOPD) patients, which was absent in 506 normal controls. Expression of the A320V mutant in 293T cells demonstrated increased colocalization of VPS35 with CI-MPR and decreased CI-MPR and lysosomal-associated membrane protein 2 (LAMP2) levels. Decreased CI-MPR manifested in missorting of cathepsin D and decreased proteolysis of α-synuclein. A320V mutation also increased mitochondrial E3 ubiquitin protein ligase 1 (MUL1) and thus led to mitofusin 2 (MFN2) degradation. The results suggest that the expression of VPS35 A320V leads to disrupted CI-MPR sorting and impaired mitochondrial morphology, which may partly explain its action in PD.
Enhancement of CO2 Reforming of CH4 Reaction Using Ni,Pd,Pt/Mg1−xCex4+O and Ni/Mg1−xCex4+O Catalysts
Authors: Al-Doghachi Faris A. J. , Jassim Ali F. A. , Taufiq-Yap Yun Hin
Published: October 2020

Catalysts Ni/Mg1−xCex4+O and Ni,Pd,Pt/Mg1−xCex4+O were developed using the co-precipitation–impregnation methods. Catalyst characterization took place using XRD, H2-TPR, XRF, XPS, Brunauer–Emmett–Teller (BET), TGA TEM, and FE-SEM. Testing the catalysts for the dry reforming of CH4 took place at temperatures of 700–900 °C. Findings from this study revealed a higher CH4 and CO2 conversion using the tri-metallic Ni,Pd,Pt/Mg1−xCex4+O catalyst in comparison with Ni monometallic systems in the whole temperature ranges. The catalyst Ni,Pd,Pt/Mg0.85Ce4+0.15O also reported an elevated activity level (CH4; 78%, and CO2; 90%) and an outstanding stability. Carbon deposition on spent catalysts was analyzed using TEM and Temperature programmed oxidation-mass spectroscopy (TPO-MS) following 200 h under an oxygen stream. The TEM and TPO-MS analysis results indicated a better anti-coking activity of the reduced catalyst along with a minimal concentration of platinum and palladium metals.
Nucleated Red Blood Cells: Could They Be Indicator Markers of Illness Severity for Neonatal Intensive Care Unit Patients?
Authors: Sokou Rozeta , Ioakeimidis Georgios , Lampridou Maria , Pouliakis Abraham , Tsantes Andreas G. , Tsantes Argyrios E. , Iacovidou Nicoletta , Konstantinidi Aikaterini
Published: October 2020

Background: We aimed to assess whether nucleated red blood cells (NRBCs) count could serve as a diagnostic and prognostic biomarker for morbidity and mortality in critically ill neonates. Methods: The association between NRBCs count and neonatal morbidity and mortality was evaluated in an observational cohort of critically ill neonates hospitalized in our neonatal intensive care unit over a period of 69 months. The discriminative ability of NRBCs count as diagnostic and prognostic biomarkers was evaluated by performing the Receiver Operating Characteristics (ROC) curve analysis. Results: Among 467 critically ill neonates included in the study, 45 (9.6%) of them experienced in-hospital mortality. No statistically significant difference was found with regards to NRBCs count between survivors and non-survivors, although the median value for NRBCs was sometimes higher for non-survivors. ROC curve analysis showed that NRBCs is a good discriminator marker for the diagnosis of perinatal hypoxia in neonates with area under the curve (AUC) [AUC 0.710; 95% confidence interval (CI), 0.660–0.759] and predominantly in preterm neonates (AUC 0.921 (95% CI, 0.0849–0.0993)) by using a cut-off value of ≥11.2%, with 80% sensitivity and 88.7% specificity. NRBCs also revealed significant prognostic power for mortality in septic neonates (AUC 0.760 (95% CI, 0.631–0.888)) and especially in preterms with sepsis (AUC 0.816 (95% CI, 0.681–0.951)), with cut-off value ≥ 1%, resulting in 81.6% sensitivity and 78.1% specificity. Conclusion: NRBCs count may be included among the early diagnostic and prognostic markers for sick neonates.
Rapidly Solidified Gas-Atomized Aluminum Alloys Compared with Conventionally Cast Counterparts: Implications for Cold Spray Materials Consolidation
Authors: Sousa Bryer , Walde Caitlin , Champagne Victor , Nardi Aaron , Sisson Richard , Cote Danielle
Published: October 2020

In this work, three commercially available aluminum alloy systems (Al 2024, Al 6061, and Al 7075) were considered to explicitly capture the differences in material properties associated with a rapidly solidified, gas-atomized particulate feedstock as compared with their conventionally cast counterparts. Differences between the microstructural, thermodynamic, mechanical, and kinetic behaviors associated with gas-atomized and conventionally bulk counterparts have been tacitly assumed by the cold spray community. However, many researchers continue to utilize legacy properties from bulk materials when simulating particle impact phenomena in silico, for example. By way of recognizing the fact that bulk material properties may not serve as substitutes for gas-atomized powder property input parameters for cold spray process simulation and computation in silico, enhanced cold spray research and development will be more easily achieved. Therefore, understanding the feedstock powder characteristics for use in cold spray can lead to fine-tuning the properties of cold spray consolidations. Optical microscopy, scanning electron microscopy, nanoindentation, microhardness, differential scanning calorimetry, elemental analysis, and cooling rate calculations were utilized. This work confirms preliminary findings that powder alloys may not be treated the same way as their bulk counterparts in so far as the enactment of heat treatment processing parameters are concerned. Specifically, vast discrepancies were found in the grain size, secondary phases, and mechanical behavior between the powder and cast versions of each alloy.
Microstructure and Mechanical Properties of Ti-6Al-4V Fabricated by Electron Beam Melting
Authors: Ran Jiangtao , Jiang Fengchun , Sun Xiaojing , Chen Zhuo , Tian Cao , Zhao Hong
Published: October 2020

Electron beam melting technique is a kind of near-net shaping, environmentally friendly metal additive manufacturing technique, which can form high-performance metal parts with complex shapes. It has been widely applied in the aerospace industry, biomedical application, automobile manufacturing, and other fields. Ti-6Al-4V is the most widely researched and applied alloy in the additive manufacturing field, but its microstructure is diverse, and its mechanical properties vary greatly. In this study, the effect of process parameters on the microstructure and the resulting mechanical properties of Ti-6Al-4V alloy was researched. The results show that the yield strength of Ti-6Al-4V alloy with a bimodal microstructure is higher than those with a basketweave microstructure. Energy dispersion spectrum (EDS) line scan and area scan results show that there is no element enrichment for the specimens with the highest yield strength. A speed factor of less than 40 is a must for obtaining relatively dense Ti-6Al-4V parts built with electron beam melting. We have done basic research for the subsequent manufacturing of complex shape parts, which is helpful to promote the application of electron beam melting technology in the aerospace field.
Tunable Stokes Laser Based on KTiOPO4 Crystal
Authors: Wang Zecheng , Zhang Xingyu , Cong Zhenhua , Liu Zhaojun , Chen Xiaohan , Qin Zengguang , Ming Na , Guo Quanxin
Published: October 2020

The characteristics of a tunable Stokes laser based on the cascaded stimulated polariton scattering and stimulated Raman scattering in KTiOPO4 crystal were studied experimentally and theoretically. When the pumping wavelength was 1064 nm, the Stokes laser output wavelength was able to be tuned discontinuously from 1112.08 nm to 1113.64 nm, from 1114.94 nm to 1115.77 nm, and from 1117.37 nm to 1119.92 nm, and the maximum output power appeared at 1118.86 nm. With a pulse repetition frequency of 7 kHz and a pump power of 6.0 W, the maximum output power of the Stokes laser reached 734 mW, and the corresponding diode to laser conversion efficiency was 12.2%. The rate equations describing the temporal evolutions of the fundamental and Stokes waves by noncollinear stimulated polariton scattering and the Stokes wave by collinear stimulated Raman scattering were derived. They were used to simulate the tunable Stokes laser. The calculated results were in agreement with the experimental results on the whole.
Phase-Specific Strain Hardening and Load Partitioning of Cold Rolled Duplex Stainless Steel X2CrNiN23-4
Authors: Simon Nicola , Krause Maximilian , Heinemann Paul , Erdle Hannes , Böhlke Thomas , Gibmeier Jens
Published: October 2020

Multi-phase materials often times consist of constituents with high contrasts in phase-specific mechanical properties. Here, even after homogeneous plastic deformation phase-specific residual stresses develop that may affect the components behaviour in service. For numerical simulation of phase-specific residual stresses, knowledge of the particular phase-specific strain hardening behaviour is essential. In this study, the strain hardening of ferrite and austenite in cold rolled duplex stainless steel of type X2CrNiN23-4 is investigated. By means of X-ray diffraction, the phase-specific load partitioning and residual stress evolution are analysed for uniaxial load application in three directions within the sheets plane, taking into account the sheet metals phase specific anisotropy. In order to assess the necessity for experimental determination of anisotropic phase specific behaviour, the strain hardening parameters, derived from only one loading direction, are implemented in a mean-field approach for prediction of phase-specific stresses. A simplified simulation approach is applied that only considers macroscopic plastic anisotropy and results are compared to experimental findings. For all investigated loading directions, it was observed that austenite is the high-strength phase. This load partitioning behaviour was confirmed by the evolution of phase-specific residual stresses as a result of uniaxial elasto-plastic loading. With the simplified and fast numerical approach, satisfying results for prediction of anisotropic phase-specific (residual) stresses are obtained.
Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis
Authors: Prasitlumkum Narut , Chokesuwattanaskul Ronpichai , Thongprayoon Charat , Bathini Tarun , Vallabhajosyula Saraschandra , Cheungpasitporn Wisit
Published: October 2020

Introduction: The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. Methods: We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. Results: We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1–23.8% with substantial heterogeneity (I2 = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. Conclusion: The incidence of COVID-19-related myocardial injury ranges from 16.1–23.8%. Further larger studies are anticipated, as the pandemic is still ongoing.
Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Randomized Controlled Pilot Study
Authors: Miyazawa Haruna , Nakajima Takako , Horimizu Makoto , Okuda Kazuhiro , Sugita Noriko , Yamazaki Kyoko , Li Lu , Hayashi-Okada Yoshiko , Arita Takuya , Nishimoto Misa , Nishida Mieko , Genco Robert , Yamazaki Kazuhisa
Published: October 2020

The aim of this study was to examine the effect of adjunct local minocycline administration on the microbiological parameters of subgingival plaque samples in the residual periodontal pockets. Ten chronic periodontitis patients under a supportive periodontal therapy regimen were recruited. After subgingival debridement, either 2% minocycline gel, Periocline™, (Test Group) or a placebo (Control Group) was administered to the selected sites once a week for three weeks. Subgingival plaque was collected at baseline, and at four weeks and eight weeks. The microbiological composition was analyzed by 16S ribosomal RNA sequencing. In the Test Group, α-diversity (evenness) decreased compared to the baseline (p = 0.005) and was lower compared to the control group at four weeks (p = 0.003). The microbial community composition between the two groups was significantly different at four weeks (p = 0.029). These changes were attributable to a decrease in the bacteria associated with periodontitis and an increase in the bacteria associated with periodontal health. Additionally, the improvement in bleeding on probing continued at eight weeks; however, there were little microbial effects of 2% minocycline gel observed at eight weeks. The control group demonstrated no change throughout the eight-week experimental period. Thus, local minocycline administration can change the subgingival microbial community of residual periodontal pockets.
Characteristic Analysis and Predictive Torque Control of the Modular Three-Phase PMSM for Low-Voltage High Power Application
Authors: Rao Zhimeng , Zhang Wenjuan , Wu Gongping , Zheng Jian , Huang Shoudao
Published: October 2020

In this study, a novel modular three-phase permanent magnet synchronous motor (PMSM) is proposed for low-voltage high power applications. The proposed modular three-phase PMSM has an independent segregated three-phase winding configuration, facilitating the implementation of the control algorithm. Firstly, on the basis of the electromagnetic properties, the mathematical model of the modular three-phase PMSM is established, considering the asymmetrical mutual inductances investigated by finite element analysis (FEA). Then, the predictive torque control (PTC) method combining the inductance characteristics of modular three-phase PMSM is developed, and excellent performance is obtained by adjusting the stator flux and torque. Finally, simulation and experiment are performed, and the results show that the proposed novel modular three-phase PMSM with the PTC method exhibits excellent control performance, and small stator current total harmonic distortion (THD).
Drones over the “Black Desert”: The Advantages of Rotary-Wing UAVs for Complementing Archaeological Fieldwork in the Hard-to-Access Landscapes of Preservation of North-Eastern Jordan
Authors: Smith Stefan L.
Published: October 2020

The increasing availability and sinking costs of unmanned aerial vehicles (UAVs), commonly known as drones, has resulted in these devices becoming relatively commonplace on archaeological sites. The advantages of being able to rapidly obtain bespoke high-resolution images from the air are conspicuous to anyone familiar with archaeological fieldwork; meanwhile the possibilities of subsequently processing such images together with their metadata to obtain digital elevation models (DEMs) and three-dimensional (3-D) models provide additional bonuses to analysis and interpretation. The recent use of a rotary-wing drone by the Western Harra Survey (WHS), an archaeological project co-directed by the author in the “Black Desert”, or Harra, of north-eastern Jordan, showcases these advantages in the context of a landscape that (a) is subject to negligible transformation processes and (b) is difficult to access, both by vehicle and on foot. By using processed drone imagery to record in detail prehistoric basalt structures visible on the surface and their surroundings, morphological site typologies hypothesised from satellite imagery were confirmed, relative dating within sites ascertained, structural features and damage documented, spatial relationships to natural resources established, offsite features traced, modern threats to heritage catalogued, and practically inaccessible sites investigated. Together, these results, most of which were only obtainable and all of which were obtained more rapidly by using a drone, represent significant insights into this underrepresented region, and provide a case-study for the benefits of these devices in other landscapes of a similar nature.
Heat Extremes, Public Health Impacts, and Adaptation Policy in Germany
Authors: Mücke Hans-Guido , Litvinovitch Jutta Maria
Published: October 2020

Global warming with increasing weather extremes, like heat events, is enhancing impacts to public health. This essay focuses on unusual extreme summer heat extremes occurring in Germany at higher frequency, longer duration, and with new temperature records. Large areas of the country are affected, particularly urban settlements, where about 77% of the population lives, which are exposed to multiple inner-city threats, such as urban heat islands. Because harm to public health is directly released by high ambient air temperatures, local and national studies on heat-related morbidity and mortality indicate that vulnerable groups such as the elderly population are predominantly threatened with heat-related health problems. After the severe mortality impacts of the extreme summer heat 2003 in Europe, in 2008, Germany took up the National Adaptation Strategy on Climate Change to tackle and manage the impacts of weather extremes, for example to protect people’s health against heat. Public health systems and services need to be better prepared to improve resilience to the effects of extreme heat events, e.g., by implementing heat health action plans. Both climate protection as well as adaptation are necessary in order to be able to respond as adequate as possible to the challenges posed by climate change.
What Is Urban after All? A Critical Review of Measuring and Mapping Urban Typologies in Portugal
Authors: Henriques Cristina , Domingues Alexandre , Pereira Margarida
Published: October 2020

The concept of urban area is complex and has been discussed for many years by several authors and organisations through different perspectives and methodological approaches. For administrative and comparison purposes statistical institutions, both at the national and international levels, classify territories according to a certain degree of urbanisation defining typologies from which indicators and certain public policies are applied. The purpose of this study is to discuss the relevance and suitability of different urban typologies. Through mapping and measuring the data of official documents, the urban dimension of Mainland Portuguese territory is discussed and its usefulness concerning the allocation of resources for promoting territorial cohesion is stressed. Results show the inadequacy of these classifications to inform planning actions, decision making, and to promote territorial policies. It also provides evidence of inaccuracies that distort the reading of the territorial reality of the case study.
Methodology of Sub-Catchment Division Considering Land Uses and Flow Directions
Authors: Li Chengming , Fan Zixian , Wu Zheng , Dai Zhaoxin , Liu Li , Zhang Chengcheng
Published: October 2020

Catchment division constitutes the foundation for urban water flood forecasting but represents a technically challenging task. The accurate division of catchments is significant for precisely forecasting urban waterlogging. However, existing catchment division methods usually lead to produce results that do not accurately reflect the actual land-use distributions. In recent years, most research has been performed in smaller study areas (less than 10 km2), in residential areas, parks and campuses, and usually focused on a single landscape type. However, for large highly urbanized areas with complex land uses, due to the spatial heterogeneity and complexity of such areas in terms of building, traffic network and hydrology, etc., there is few studies on sub-catchment division. Moreover, the division results by using existing method usually have deviate with the actual land-type distributions. To address the above-mentioned issues, a sub-catchment division method was here proposed that accounts for land-use types and flow directions, and it is suitable for large urban areas by introducing an auto-adaptive threshold adjustment in a novel algorithm. First, the study area is divided into first- and second-level (FL and SL, respectively) catchments according to the macroscale features such as natural landforms, canals, and pipe network. Second, an amended DEM (Digital Elevation Model) and flow direction data are used to divide the SL catchments into third-level direction-based (D-B) catchments. Finally, a novel land use-based algorithm is proposed to divide the D-B catchments into the “smallest” catchments (S-catchments). A large-scale area (44 km2) in Dongying City of China was employed to validate the proposed method. The experiment showed that the proposed method is suitable for subcatchment divisions in large regions and can ensure that the subcatchments are consistent with the actual distribution of land uses and runoff directions.
Machine Learning Framework for the Estimation of Average Speed in Rural Road Networks with OpenStreetMap Data
Authors: Keller Sina , Gabriel Raoul , Guth Johanna
Published: October 2020

Average speed information, which is essential for routing applications, is often missing in the freely available OpenStreetMap (OSM) road network. In this contribution, we propose an estimation framework, including different machine learning (ML) models that estimate rural roads’ average speed based on current road information in OSM. We rely on three datasets covering two regions in Chile and Australia. Google Directions API data serves as reference data. An appropriate estimation framework is presented, which involves supervised ML models, unsupervised clustering, and dimensionality reduction to generate new input features. The regression performance of each model with different input feature modes is evaluated on each dataset. The best performing model results in a coefficient of determination R2=80.43%, which is significantly better than previous approaches relying on domain-knowledge. Overall, the potential of the ML-based estimation framework to estimate the average speed with OSM road network data is demonstrated. This ML-based approach is data-driven and does not require any domain knowledge. In the future, we intend to focus on the generalization ability of the estimation framework concerning its application in different regions worldwide. The implementation of our estimation framework for an exemplary dataset is provided on GitHub.
Mathematical Connection between Short Telomere Induced Senescence Calculation and Mortality Rate Data
Authors: Torrance Jerry B. , Goldband Steve
Published: October 2020

The last 20 years have seen a surge in scientific activity and promising results in the study of aging and longevity. Many researchers have focused on telomeres, which are composed of a series of TTAGGG repeat nucleotide sequences at the ends of each chromosome. Measurements of the length of these telomere strands show that they decrease in length with increasing age, leading many authors to propose that when the length of these telomere strands decreases sufficiently, the cells enter into a state of replicative senescence, eventually leading to disease and death. These ideas are supported by evidence that short telomere length is correlated with increased mortality. In this paper, we extend this idea to make an actual calculation of the predicted mortality rate caused by short telomere length induced senescence (STLIS). We derive a simple equation for the mathematical relationship between telomere length and mortality rate. Using only three parameters based on telomere length measurement data of Canadians, we have calculated both the magnitude and the age dependence of the mortality rate for both men and women. We show that these calculated data are in good quantitative agreement with the actual number of Canadians that die. This agreement demonstrates the quantitative correlation between the mortality calculated by the STLIS model and the mortality of the major diseases of aging (e.g., cardiovascular disease, many cancers and diabetes mellitus), which dominate human mortality. This result represents significant progress in our understanding of the factors behind the cause of aging.
Responses of Red Flour Beetle Adults, Tribolium castaneum (Coleoptera: Tenebrionidae), and Other Stored Product Beetles to Different Pheromone Trap Designs
Authors: Doud Carl W. , Phillips Thomas W.
Published: October 2020

A series of laboratory and field experiments were performed to assess the responses of Tribolium castaneum (Herbst) and other stored-product beetles to pheromone-baited traps and trap components. A commercial Tribolium pitfall trap called the Flit-Trak M2, the predecessor to the Dome trap, was superior in both laboratory and field experiments over the other floor trap designs assessed at capturing walking T. castaneum. In field experiments, Typhaea stercorea (L.) and Ahasverus advena (Stephens) both preferred a sticky trap to the pitfall trap. Although the covered trap is effective at capturing several other species of stored product beetles, the synthetic Tribolium aggregation pheromone lure is critical for the pitfall trap’s efficacy for T. castaneum. Although the food-based trapping oil used in the pitfall trap was not found to be attractive to T. castaneum when assayed alone, it had value as an enhancer of the pheromone bait when the two were used together in the trap. A dust cover modification made to go over the pitfall trap was effective in protecting the trap from dust, although the trap was still vulnerable to dust contamination from sanitation techniques that used compressed air to blow down the mill floors. Capture of T. castaneum in the modified trap performed as well as the standard trap design in a non-dusty area of a flour mill, and was significantly superior over the standard trap in a dusty area. T. castaneum responded in flight outside a flourmill preferentially to multiple funnel traps with pheromone lures compared to traps without pheromone.
Exploring a Cost-Efficient Model for Predicting Cerebral Aβ Burden Using MRI and Neuropsychological Markers in the ADNI-2 Cohort
Authors: Ko Hyunwoong , Park Seho , Kwak Seyul , Ihm Jungjoon ,   for the ADNI Research Group
Published: October 2020

Many studies have focused on the early detection of Alzheimer’s disease (AD). Cerebral amyloid beta (Aβ) is a hallmark of AD and can be observed in vivo via positron emission tomography imaging using an amyloid tracer or cerebrospinal fluid assessment. However, these methods are expensive. The current study aimed to identify and compare the ability of magnetic resonance imaging (MRI) markers and neuropsychological markers to predict cerebral Aβ status in an AD cohort using machine learning (ML) approaches. The prediction ability of candidate markers for cerebral Aβ status was examined by analyzing 724 participants from the ADNI-2 cohort. Demographic variables, structural MRI markers, and neuropsychological test scores were used as input in several ML algorithms to predict cerebral Aβ positivity. Out of five combinations of candidate markers, neuropsychological markers with demographics showed the most cost-efficient result. The selected model could distinguish abnormal levels of Aβ with a prediction ability of 0.85, which is the same as that for MRI-based models. In this study, we identified the prediction ability of MRI markers using ML approaches and showed that the neuropsychological model with demographics can predict Aβ positivity, suggesting a more cost-efficient method for detecting cerebral Aβ status compared to MRI markers.
The Acquisition of Preposition + Article Contractions in L3 Portuguese among Different L1-Speaking Learners: A Variationist Approach
Authors: Picoral Adriana , Carvalho Ana Maria
Published: October 2020

This paper sheds light on the paths of third language (L3) acquisition of Portuguese by Spanish–English speakers whose first language is Spanish (L1 Spanish), English (L1 English), or both in the case of heritage speakers of Spanish (HL). Specifically, it looks at the gradual acquisition of a categorical rule in Portuguese, where some prepositions are invariably contracted with the determiner that follows them. Based on a corpus of 1910 written assignments by Portuguese L3 learners, we extracted 21,879 tokens in obligatory contraction contexts and submitted them to a multivariate analysis. This analysis allowed for the investigation of the impact of linguistic (type of preposition and definite article number and gender) and extra-linguistic factors (course level and learner’s language background), with logistic regression modeling with sum contrasts and individual as a random effect. While results point to some clear similarities across the three language groups—all learners acquired the contractions in a u-shaped progression and used more contractions with the a preposition and fewer with the por preposition—participants acquire contractions at a higher rate when the article is singular than when it is plural, and in the case of HL speakers, more so when the article is masculine than when it is feminine. These results confirm the facilitatory role of a previously acquired language (i.e., Spanish) that is typologically similar to the target language (i.e., Portuguese) in transfer patterns during L3 acquisition.
Primary Pleural Hydatidosis—A Rare Occurrence: A Case Report and Literature Review
Authors: Savu Cornel , Melinte Alexandru , Grigorie Vasile , Iliescu Laura , Diaconu Camelia , Dimitriu Mihai , Socea Bogdan , Stiru Ovidiu , Varlas Valentin , Savu Carmen , Balescu Irina , Bacalbasa Nicolae
Published: October 2020

Introduction: The larvae of Echinococcus, a parasitic tapeworm, cause hydatid disease. The most commonly involved organ after the liver is the lung but there are cases of hydatid cysts in all systems and organs, such as brain, muscle tissue, adrenal glands, mediastinum and pleural cavity. Extra-pulmonary intrathoracic hydatidosis can be a diagnostic challenge and a plain chest x-ray can be misleading. It can also lead to severe complications such as anaphylactic shock or tension pneumothorax. The purpose of this paper is to present a severe case of primary pleural hydatidosis, as well as discussing the difficulties that come with it during diagnosis and treatment. Case Report: We present the case of a 43-year-old male, working as a shepherd, presenting with moderate dyspnea, chest pain and weight loss. Chest x-ray revealed an uncharacteristic massive right pleural effusion and thoracic computed tomography (CT) confirmed it, as well as revealing multiple cystic formations of various sizes and liquid density within the pleural fluid. Blood work confirmed our suspicion of pleural hydatidosis with an elevated eosinophil count, typical in parasite diseases. Surgery was performed by right lateral thoracotomy and consisted of removal of the hydatid fluid and cysts found in the pleura. Patient was discharged 13 days postoperative with Albendazole treatment. Conclusion: Cases of primary pleural hydatidosis are very rare but must be taken into consideration in patients from endemic regions with jobs that may have exposure to this parasite. Proper treatment, both surgical and antiparasitic medication, can lead to a full recovery and a low chance of recurrent disease.
Ecological Structuring of Temperate Bacteriophages in the Inflammatory Bowel Disease-Affected Gut
Authors: Nishiyama Hiroki , Endo Hisashi , Blanc-Mathieu Romain , Ogata Hiroyuki
Published: October 2020

The aim of this study was to elucidate the ecological structure of the human gut temperate bacteriophage community and its role in inflammatory bowel disease (IBD). Temperate bacteriophages make up a large proportion of the human gut microbiota and are likely to play a role in IBD pathogenesis. However, many of these bacteriophages await characterization in reference databases. Therefore, we conducted a large-scale reconstruction of temperate bacteriophage and bacterial genomes from the whole-metagenome sequence data generated by the IBD Multi’omics Database project. By associating phages with their hosts via genome comparisons, we found that temperate bacteriophages infect a phylogenetically wide range of bacteria. The majority of variance in bacteriophage community composition was explained by variation among individuals, but differences in the abundance of temperate bacteriophages were identified between IBD and non-IBD patients. Of note, in active ulcerative colitis patients, temperate bacteriophages infecting Bacteroides uniformis and Bacteroides thetaiotaomicron—two species experimentally proven to be beneficial to gut homeostasis—were over-represented, whereas their hosts were under-represented in comparison with non-IBD patients. Supporting the mounting evidence that gut viral community plays a vital role in IBD, our results show potential association between temperate bacteriophages and IBD pathogenesis.
Biotransformation of Food-Grade and Nanometric TiO2 in the Oral–Gastro–Intestinal Tract: Driving Forces and Effect on the Toxicity toward Intestinal Epithelial Cells
Authors: Marucco Arianna , Prono Marion , Beal David , Alasonati Enrica , Fisicaro Paola , Bergamaschi Enrico , Carriere Marie , Fenoglio Ivana
Published: October 2020

Background: Oral exposure to titanium dioxide (TiO2) is common since it is widely used in food and pharmaceutical products. Concern on the safety of this substance has been recently raised, due to the presence of an ultrafine fraction in food-grade TiO2. Discrepancy exists among data reported in in vitro and in vivo studies on intestinal acute/chronic toxicity of TiO2. This might be due to the different biological identity of TiO2 in traditional in vitro test by respect in vivo conditions. Methods: One food-grade TiO2 and two nanometric TiO2 samples were treated with a simulated human digestive dystem (SHDS) in order to investigate the bio-transformation occurring to the particles once ingested in term of size distribution (Dynamic Light Scattering—DLS-, Flow Particle Imaging, Asymmetric Flow Field Flow Fractionation-AF4-) and surface modification (Electrophoretic Light Scattering—ELS-, Electron Paramagnetic Resonance Spectroscopy—EPR-). The effect of SHDS on the cyto-, genotoxicity and potential to induce oxidative stress towards human colorectal carcinoma HCT116 cells was also assessed. Results: Aggregation as a consequence of the high ionic strength of the gastric and intestinal simulated fluids was observed, together with the formation of a partially irreversible bio-corona containing phosphate ions and proteins. Such bio-corona led to a partial masking of the TiO2 particles surface and reactivity. Pristine and treated TiO2 nanoparticles showed comparable acute toxicity and genotoxicity toward HCT116 cells, whereas a small decrease of the induction of oxidative stress after treatment was observed. Conclusions: Overall the results underline the importance of SHDS as a tool to improve the predictive power of in vitro tests towards intestinal nanomaterial toxicity.
Nanostructured and Spiky Gold Shell Growth on Magnetic Particles for SERS Applications
Authors: Bedford Erin E. , Méthivier Christophe , Pradier Claire-Marie , Gu Frank , Boujday Souhir
Published: October 2020

Multifunctional micro- and nanoparticles have potential uses in advanced detection methods, such as the combined separation and detection of biomolecules. Combining multiple tasks is possible but requires the specific tailoring of these particles during synthesis or further functionalization. Here, we synthesized nanostructured gold shells on magnetic particle cores and demonstrated the use of them in surface-enhanced Raman scattering (SERS). To grow the gold shells, gold seeds were bound to silica-coated iron oxide aggregate particles. We explored different functional groups on the surface to achieve different interactions with gold seeds. Then, we used an aqueous cetyltrimethylammonium bromide (CTAB)-based strategy to grow the seeds into spikes. We investigated the influence of the surface chemistry on seed attachment and on further growth of spikes. We also explored different experimental conditions to achieve either spiky or bumpy plasmonic structures on the particles. We demonstrated that the particles showed SERS enhancement of a model Raman probe molecule, 2-mercaptopyrimidine, on the order of 104. We also investigated the impact of gold shell morphology—spiky or bumpy—on SERS enhancements and on particle stability over time. We found that spiky shells lead to greater enhancements, however their high aspect ratio structures are less stable and morphological changes occur more quickly than observed with bumpy shells.
Synthesis, Characterization, and Photocatalytic Evaluation of Manganese (III) Phthalocyanine Sensitized ZnWO4 (ZnWO4MnPc) for Bisphenol A Degradation under UV Irradiation
Authors: Anucha Chukwuka Bethel , Altin Ilknur , Biyiklioglu Zekeriya , Bacaksiz Emin , Polat Ismail , Stathopoulos Vassilis N.
Published: October 2020

ZnWO4MnPc was synthesized via a hydrothermal autoclave method with 1 wt.% manganese (iii) phthalocyanine content. The material was characterized for its structural and morphological features via X-ray diffraction (XRD) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, transmission emission microscopy (TEM), scanning electron microscopy-Energy dispersive X-ray spectroscopy (SEM-EDX), N2 adsorption–desorption at 77K, X-ray photoelectron spectroscopy (XPS), and UV-visible/diffuse reflectance spectroscopy(UV-vis/DRS). ZnWO4MnPc photocatalytic performance was tested on the degradation of bisphenol A (BPA). The ZnWO4MnPc material removed 60% of BPA after 4 h of 365 nm UV irradiation. Degradation process improved significantly to about 80% removal in the presence of added 5 mM H2O2 after 4 h irradiation. Almost 100% removal was achieved after 30 min under 450 nm visible light irradiation in the presence of same concentration of H2O2. The effect of ions and humic acid (HA) towards BPA removal was also investigated.