bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial and Ecological Drivers of Genetic Structure in Greek Populations of Alkanna tinctoria (Boraginaceae), a Polyploid Medicinal Herb
Authors: Ahmad Muhammad , Leroy Thibault , Krigas Nikos , Temsch Eva M. , Weiss-Schneeweiss Hanna , Lexer Christian , Sehr Eva Maria , Paun Ovidiu
Published: July 2021

Background and Aims:Quantifying genetic variation is fundamental to understand a species’ demographic trajectory and its ability to adapt to future changes. In comparison with diploids, however, genetic variation and factors fostering genetic divergence remain poorly studied in polyploids due to analytical challenges. Here, by employing a ploidy-aware framework, we investigated the genetic structure and its determinants in polyploidAlkanna tinctoria(Boraginaceae), an ancient medicinal herb that is the source of bioactive compounds known as alkannin and shikonin (A/S). From a practical perspective, such investigation can inform biodiversity management strategies.

Methods:We collected 14 populations ofA. tinctoriawithin its main distribution range in Greece and genotyped them using restriction site-associated DNA sequencing. In addition, we included two populations ofA. sieberi. By using a ploidy-aware genotype calling based on likelihoods, we generated a dataset of 16,107 high-quality SNPs. Classical and model-based analysis was done to characterize the genetic structure within and between the sampled populations, complemented by genome size measurements and chromosomal counts. Finally, to reveal the drivers of genetic structure, we searched for associations between allele frequencies and spatial and climatic variables.

Key Results:We found support for a marked regional structure inA. tinctoriaalong a latitudinal gradient in line with phytogeographic divisions. Several analyses identified interspecific admixture affecting both mainland and island populations. Modeling of spatial and climatic variables further demonstrated a larger contribution of neutral processes and a lesser albeit significant role of selection in shaping the observed genetic structure inA. tinctoria.

Conclusion:Current findings provide evidence of strong genetic structure inA. tinctoriamainly driven by neutral processes. The revealed natural genomic variation in GreekAlkannacan be used to further predict variation in A/S production, whereas our bioinformatics approach should prove useful for the study of other non-model polyploid species.
Demographic Characteristics, Motivation and Perception of Change as Determinants of Memory Compensation Self-Reports After Acquired Brain Injury
Authors: Martin Sophie , Mooruth Draushika , Guerdoux-Ninot Estelle , Mazzocco Clémence , Brouillet Denis , Taconnat Laurence , Trouillet Raphaël
Published: July 2021

Introduction

Individuals with brain injuries experience cognitive and emotional changes that have long-lasting impacts on everyday life. In the context of rehabilitation, surveys have stressed the importance of compensating for memory disturbances to ease the impact of disorders on day-to-day autonomy. Despite extensive research on the nature of neurocognitive impairments following brain injury, few studies have looked at patients’ perceptions of these day-to-day compensations. This study examines these perceptions; in particular, what brain-injured people believe they do to compensate for memory deficiencies in everyday life. It also investigates the determinants of reported compensation strategies (age, gender, perceived stress, change awareness and motivation to succeed).

Methods

Eighty patients and 80 controls completed the French Memory Compensation Questionnaire, a self-report measure of everyday memory compensation. Five forms of compensation were investigated: External and Internal strategies, Reliance on social help, and investments in Time and Effort, along with two general factors: the degree of importance attached to Success (motivation) and perceptions of Change. Participants also completed measures of demographic and emotional aspects that may affect everyday compensation perceptions.

Results

The brain-injured group reported significantly more frequent use of memory compensation strategies than controls, with the exception of External aids. Large effects were observed for Reliance and Effort. Demographic, motivation and perception of change determinants were found to have different effects depending on the compensation strategy, and mediated the direct effect of brain injury on reported compensation.

Conclusion

Clinical and rehabilitation neuropsychologists often seek to have a better sense of how their patients perceive their compensatory behaviors. In practice, such an understanding is needed to help select appropriate methods and improve the long-term impact of rehabilitation programs: memory rehabilitation will fail if neuropsychologists do not deal, first and foremost, with the emotional and metacognitive issues surrounding traumatic brain injury (TBI), rather than focusing on cognitive efficiency.
Fanning the Flames of Passion: A Develop Mindset Predicts Strategy-Use Intentions to Cultivate Passion
Authors: Chen Patricia , Lin Yuching , Pereira Don J. H. , O’Keefe Paul A. , Yates J. Frank
Published: July 2021

College students are encouraged to major in subjects they are passionate about but less often advised about what to do when passion is low. What self-regulatory strategies do students use to up-regulate their passion toward their subjects, and how might they be oriented toward using such effective strategies? Three studies examined how the belief that passion is developed – a “develop” mindset – relates to students’ intentions to use strategies to actively grow their passion. The more strongly students endorsed a develop mindset, the more of these “cultivation strategies” they reported using, and in turn, the larger their increase in reported passion toward their subject majors (Study 1). Instilling a develop mindset causally increased students’ intentions to use more cultivation strategies (Study 2) – with some effects lasting up to a year (Study 3). Instilling a develop mindset can potentially help students to ignite their passion when its flame burns low.
Product Creativity as an Identity Issue: Through the Eyes of New Product Development Team Members
Authors: Park Jin Suk , Suzuki Satoko
Published: July 2021

In this study, we introduce a concept of product identification that denotes the overlap between identities of a new product and its developer. As creativity is the most important identity dimension in the new product, we draw on two dimensions of creativity: novelty and meaningfulness. According to the argument that novelty represents exploration, whereas meaningfulness represents exploitation, we hypothesize that product novelty is associated with an explorative behavior of new product team members, while product meaningfulness is associated with exploitative behavior. More importantly, product identification is proposed as the mechanism that explains the amplification effect of product identity on team members. Based on survey data collected from 200 Japanese new product development (NPD) team members, we conduct a statistical analysis to test the hypotheses. The findings demonstrate the alignment between the identity of a new product and the behaviors of the NPD members, which is amplified by product identification but not by organizational identification.
Impact of the COVID-19 Pandemic on the Mental Health of College Students: A Systematic Review and Meta-Analysis
Authors: Li Yang , Wang Aiwen , Wu Yalin , Han Nana , Huang Huiming
Published: July 2021

Background

The coronavirus disease (COVID-19) pandemic has been spreading and brought unprecedented psychological pressure on people across the entire globe since December 2019.

Objectives

To synthesize the existing evidence of the prevalence of mental health status during the epidemic and provide the basis for mental health education.

Materials and methods

The literature search was conducted in nine databases from December 2019 to October 2020. The risk of bias for each study was assessed, and the random-effects meta-analysis was used to estimate the prevalence of specific mental health problems. The review protocol was registered in PROSPERO with the registration number CRD42020208619.

Results

About 27 studies were included in the analysis with a total of 706,415 participants combined, and 14 mental health problems were gathered. Meta-analysis showed that the prevalence of depression was 39% (95% CI: 27–51%) and that of anxiety was 36% (95% CI: 26–46%). Subgroup analysis indicated that the prevalence of depression and anxiety varied among nations and due to the survey date. The prevalence of depression (60%, 95% CI: 46–74%) and anxiety (60%, 95% CI: 46–74%) in non-Chinese college students was higher than those in Chinese college students (26%, 95% CI: 21–30% and 20%, 95% CI: 14–26%). The proportion of depression (54%, 95% CI: 40–67%) and anxiety (37%, 95% CI: 26–48%) was higher after March 1 than before it (21%, 95% CI: 16–25% and 19%, 95% CI: 13–25%).

Conclusions

The meta-analysis results presented that the prevalence of depression (39%) or anxiety (36%) among college students greatly increased during the COVID-19 pandemic. In addition, the mental health of college students is affected by the nations and the survey date. It was necessary to take measures to reduce mental health risks during the pandemic.
The Effect of Computerized Cognitive Behavioral Therapy on People's Anxiety and Depression During the 6 Months of Wuhan's Lockdown of COVID-19 Epidemic: A Pilot Study
Authors: Lv Zhangwei , Li Jinyang , Zhang Bin , Zhang Ning , Wang Chun
Published: July 2021

Background: The effectiveness of computerized cognitive behavioral therapy (CCBT) has been proven for mild and moderate anxiety and depression. In 2016, the first official Chinese CCBT system was launched by Chinese Cognitive Behavior Therapy Professional Organizations and included four items: getting out of depression, overcoming anxiety, staying away from insomnia and facing Obsessive-compulsive disorder. During the COVID-19 epidemic, Chinese CCBT system served the public for free. This study explored the effects of CCBT on anxiety and depression by comparing the use of the platform during the epidemic and during the same period in 2019.

Methods: Users were divided into a depression group or an anxiety group according to their own discretion. The subjects used the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) before each training. Each training group completed the corresponding CCBT training project, which had 5–6 training sessions, an average of once every 5 days. The training content in 2019 and 2020 was identical. This study compared the demographic characteristics, depression, and anxiety levels of CCBT platform users during the lockdown period in Wuhan (LP2020), where the outbreak was concentrated in China, from January 23 to July 23, 2020 and the same period in 2019 (SP2019).

Result: (1) There were significant differences in gender (χ2 = 7.215, P = 0.007), region (χ2 = 4.225, P = 0.040) and duration of illness (χ2 = 7.867, P = 0.049) between the two periods. (2) There was a positive Pearson correlation between the number of users of CCBT platform during LP2020 and number of confirmed cases of COVID-19 in each province (r = 0.9429, P < 0.001). (3) In LP2020, the SAS (t = 2.579, P = 0.011) and SDS (t = 2.894, P = 0.004) scores at T0 in Hubei were significantly higher than those in other regions. (4) The CCBT platform has an obvious effect on anxiety (F = 4.74, P = 0.009) and depression on users (F = 4.44, P = 0.009).

Conclusion: This study showed women, students and people who are more seriously affected by the epidemic were more likely to accept the CCBT training. The CCBT platform made a significant contribution toward alleviating the anxiety and depression symptoms of users during the epidemic. When face-to-face psychotherapy is not available during the epidemic, CCBT can be used as an effective alternative.
Cyclists' Perception of Maintenance and Operation of Cycling Infrastructure—Results From a Norwegian Survey
Authors: Aasvik Ole , Bjørnskau Torkel
Published: July 2021

The Norwegian authorities want to limit the extent of car use in city areas to existing levels. Such a limitation would help combat climate change, improve health of citizens, and alleviate congestion. This implies that any further increase in transport needs will have to be met by walking, cycling and use of public transport. Reaching this ambitious goal requires knowledge about cyclists' preferences concerning operation and maintenance (M&O) of roads and foot/cycle paths. Previous research suggests that M&O have great implications for travel mode choice, bicycle route/path choice, safety, security, and comfort. With the need to serve bicyclists of all ages and genders, this study additionally explores which M&O of roads and foot/cycle the different demographic groups perceive positively or negatively. This article reports results from a nationwide survey in the summer of 2019. Two thousand three hundred seventy-six cyclists across Norway (55% male; 29% <40; 17% >60) participated to determine the cyclists' perceptions about year-round M&O of roads and foot/cycle paths. Respondents, rather than being randomly selected, completed an internet-linked survey. The variables included maintenance of foot/cycle paths in terms of salt and snow plowing and operation and maintenance of roads in terms of glass, holes/bumps, and conditions. Our results suggest that female cyclists suffer more from adverse conditions than do males. We also find that males are more likely to cycle during winter, which is an additional indication that adverse conditions affect women and men differently. Surprisingly, older cyclists report to be less affected by poor conditions than younger cyclists. Self-selection to participate in the survey among older cyclists might be an important explanation for this result. Cycling conditions vary greatly between geographical areas, reflecting the large climatic variations across Norway. Most respondents have experienced a cycle accident where conditions contributed, and many sometimes forfeit cycling due to adverse conditions. Implications for future research and practice of M&O are discussed.
Influence of Teacher-Student Relationships and Special Educational Needs on Student Engagement and Disengagement: A Correlational study
Authors: Pérez-Salas Claudia P. , Parra Victoria , Sáez-Delgado Fabiola , Olivares Himmbler
Published: July 2021

Contemporary educational research has found that student engagement and disengagement have a relevant influence on learning outcomes. However, research on the influence of teacher–student relationships in the engagement of students with special educational needs (SEN) is scarce. The purpose of this study is to analyze the impact of teacher–student relationships, peer support at school, family support for learning, opportunities to participate at school, and SEN on engagement and disengagement of students using a sample of secondary students with SEN and typical development (TD). Through a non-experimental, correlational, and cross-sectional design, we evaluated 1,020 high school students (340 with SEN and 680 with TD) in the 9th grade (13–19 years old, M = 14.8; SD = 0.89). Teacher–student relationships, peer support at school, and family support for learning were assessed via subscales from the Student Engagement Inventory (SEI), opportunities to participate at school were measured with a subscale of the School Participation Questionnaire (SP), whereas engagement and disengagement were measured using the Multidimensional Scale of School Engagement (MSSE). Results show significant statistical differences between SEN and TD students in both student engagement and disengagement indicators. Engagement of SEN students is higher in the cognitive, emotional, and social dimensions than that of TD students. However, they also have higher disengagement in the cognitive and behavioral dimensions. Furthermore, SEN students rate their relationships with teachers more highly and perceive more opportunities for school participation than their peers. Further analyses show that teacher–student relationships are positively associated with all dimensions of student engagement and inversely with behavioral and cognitive disengagement. Although correlational, the findings suggest teacher–student relationships and school participation opportunities could be important variables for diminishing disengagement and its negative consequences for both SEN and TD students, while improving student engagement. We discuss these results considering possible implications for educational policies, practices, and research.
Cortical Thickness and Hippocampal Volume in Vascular and Non-vascular Depressed Patients
Authors: Egglefield Dakota A. , Schiff Sophie , Motter Jeffrey N. , Grinberg Alice , Rutherford Bret R. , Sneed Joel R.
Published: July 2021

Background: Reduced cortical thickness and hippocampal volume are prevalent markers of late life depression as well as mild cognitive impairment (MCI) but are conspicuously absent in the vascular depression (VD) literature. The present study aimed to determine differences in cortical thickness and hippocampal volume between VD and non-VD patients.

Methods: Participants were enrolled in an 8-week open treatment antidepressant trial. Forty-one depressed individuals aged 50 and older underwent brain magnetic resonance imaging at baseline and were classified as VD or non-VD. Cortical thickness values for the left and right entorhinal, parahippocampal, and precuneal cortices, as well as left and right hippocampal volume, were linearly regressed on VD status to determine mean differences between VD and non-VD. Covariates included site, age, sex, and mean thickness or intracranial volume.

Results: No statistical differences were found between VD and non-VD patients in cortical thickness of the bilateral precuneal, entorhinal, or parahippocampal cortices, or hippocampal volume (p > 0.001).

Conclusions: The absence of statistical differences in gray matter between VD and non-VD patients raises several diagnostic, etiological, and developmental possibilities, namely that VD may not be connected with other late-life psychiatric illnesses such as MCI or dementia and that vascular disease may not be a common etiological risk factor for depression and dementia. Larger datasets, prospective longitudinal studies, and cognitively intact controls are needed to further address these types of questions.
The Impact of the COVID-19 Pandemic on Alzheimer's Disease and Other Dementias
Authors: Gan Jinghuan , Liu Shuai , Wu Hao , Chen Zhichao , Fei Min , Xu Junying , Dou Yuchao , Wang Xiaodan , Ji Yong
Published: July 2021

Introduction: Numerous countries went into lockdown to contain the COVID-19 outbreak, which has impeded follow-up of chronic diseases, such as cognitive impairment (CI). Cognitive and neuropsychiatric changes during the COVID-19 pandemic are neglected in China, which is the world's whistleblower. To investigate the cognitive and neuropsychologic changes in CI, as well as the proportions of rapid cognitive decline (RCD) before and during the COVID-19 pandemic to provide clinical evidence for CI intervention during a public health emergency.

Methods: We performed a descriptive and retrospective study based on medical records from the memory clinic of Tianjin Dementia Institute collected through face-to-face evaluations. Information of 205 patients with CI, including patients with mild cognitive impairment and dementia, of whom 131 with Alzheimer's disease (AD) were analyzed and compared to a control group before the COVID-19 pandemic.

Results: Among the 205 CI patients, the scores on the Chinese Mini Mental State Examination (C-MMSE), the Montreal Cognitive Assessment (MoCA), activities of daily living (ADLs), and the global Neuropsychiatric Inventory (NPI) were significantly different at the baseline and follow-up evaluations (p < 0.05) after 14.07 (±2.87) months. The same findings were recorded among AD patients, and they exhibited more sleep disturbances at the follow-up than at baseline (32.8 vs. 20.6%, p = 0.035). When compared to the control group, slightly worse performance of cognitive, −1.00 (−4.00, 1.00) from the C-MMSE, −1.00 (−2.00, 0.00) on the MoCA, 1.00 (0.00, 9.00) on ADLs and neuropsychological 0.00 (−1.00, 3.50) on the global NPI profile, at the follow-up were presented, particularly for delusion, agitation, irritability, and appetite disturbances (p < 0.05). Twenty-five (19.1%) AD patients and 48 (36.6%) controls suffered RCD during the COVID-19 pandemic. Moreover, AD patients during the COVID-19 pandemic were 0.408 times (95% confidence interval: 0.232–0.716) less likely to suffer RCD than the control.

Conclusion: Confinement might ease the cognitive and neuropsychiatric deterioration of AD patients compared to those not in crisis and help prevent RCD in AD patients.
Social Marketing Intervention to Engage Older Adults in Balance Workshops for Fall Prevention: A Multicenter Quasi-Experimental Protocol Study
Authors: Goethals Luc , Barth Nathalie , Hupin David , Chapoton Boris , Guyot Jessica , Celarier Thomas , Roche Frederic , Gallopel-Morvan Karine , Bongue Bienvenu
Published: July 2021

Background: Falls affects one of three people after 65 years old, and it can lead to serious consequences. Scientific evidence point out that physical exercise is the most efficient way to prevent falls among older adults.

Objective: The main objective of this study is to determine if a social marketing program can increase the attendance rate of people aged 60 and over at group balance workshops.

Methods: This quasi-experimental multicenter study is being conducted in three French Regions (Loire, Haute-Loire and Rhône) over a period of 18 months. The Social Marketing Campaign will be done in three ways. Firstly, a Communication Campaign will take place in the two Test Areas but not in the Control Area. Secondly, flyers have been designed to be distributed by local partners. Finally, conferences for older people will be organized in the areas of intervention in order to reach the target audience for the program. The study will include people aged 60 and older who want to participate in the Balance Program.

Results: The Crédit Agricole Loire/Haute-Loire Foundation funded the study and the Jean Monnet University of Saint-Etienne reviewed it. The Ethics Committee of the University Teaching Hospital of Saint-Etienne approved and peer-reviewed it on September 6, 2019, under Reference Number IRBN622019/CHUSTE.

Conclusion: The results of this first study will demonstrate whether or not social marketing for promoting group balance workshops in the elderly will increase their attendanceship in adapted physical activity sessions, especially those that prevent falls.

Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT04136938, identifier NCT04136938.
Endorobots for Colonoscopy: Design Challenges and Available Technologies
Authors: Manfredi Luigi
Published: July 2021

Colorectal cancer (CRC) is the second most common cause of cancer death worldwide, after lung cancer (Sung et al., 2021). Early stage detection is key to increase the survival rate. Colonoscopy remains to be the gold standard procedure due to its dual capability to optically inspect the entire colonic mucosa and to perform interventional procedures at the same time. However, this causes pain and discomfort, whereby it requires sedation or anaesthesia of the patient. It is a difficult procedure to perform that can cause damage to the colonic wall in some cases. Development of new technologies aims to overcome the current limitations on colonoscopy by using advancements in endorobotics research. The design of these advanced medical devices is challenging because of the limited space of the lumen, the contorted shape, and the long tract of the large bowel. The force applied to the colonic wall needs to be controlled to avoid collateral effects such as injuries to the colonic mucosa and pain during the procedure. This article discusses the current challenges in the colonoscopy procedure, the available locomotion technologies for endorobots used in colonoscopy at a prototype level and the commercial products available.
Uptake of Contraception Among Adolescent Girls and Young Women PrEP Clients: Leveraging the Opportunity to Strengthen HIV and Sexual and Reproductive Health Integration
Authors: Pleaner Melanie , Fipaza Zukiswa , Mabetha Khuthala , Greener Letitia , Ncube Sydney , Butler Vusile , Beksinska Mags , Mullick Saiqa
Published: July 2021

The introduction of oral pre-exposure prophylaxis (PrEP) for HIV prevention was a major breakthrough in South Africa (SA). While the initial introduction focused on issues such as the development and implementation of new guidelines, supply, and the development of demand creation strategies, the need to integrate PrEP services with sexual and reproductive health (SRH) services has gained traction both globally and locally. Project PrEP was implemented in eight healthcare facilities and four mobile clinics in three provinces in SA. Using monitoring data from across the four project clusters, and 4,949 clients, over a 21-month period, we conducted an analysis of baseline routine monitoring data to examine contraceptive uptake in adolescent girls and young women (AGYW) initiating PrEP at project sites. Two-thirds of women (62.3%, n = 3,083) reported the current use of contraception at baseline, with the most commonly used methods being hormonal injectables (61.9%, n = 1,829) and male condoms (19.4%, n = 575). A third (32.3%, n = 603) of the non-contraceptive users accepted a method at PrEP initiation. From a total of 1,007 (32.7%) current contraceptive users at baseline, 865 (85.9%) chose the same or a different method at this visit. The method uptake at PrEP initiation increased the overall contraceptive prevalence by 12.2 to 74.5%. Data indicated that over a third (38.8%, n = 725) who were not using a method at baseline described themselves as consistent condom users. Although a major focus of the project was on PrEP service provision, all women were counseled and offered contraceptive services. The acceptance of a method by a third of non-users was promising; however, more understanding of those who did not take up a method is required. The need to leverage opportunities for the promotion of the integration of HIV and family planning at all levels of PrEP provision was highlighted.
Ambivalent Assets: The Success of Sand-Storage Dams for Rainwater Harvesting in Kitui County, Kenya
Authors: Ertsen M. W. , Ngugi K. N.
Published: July 2021

This paper assesses the success of sand-storage dams in Kitui, Kenya—with “success” being considered to relate to the amount of water that dams can store, and the usability of the water in terms of access, quantity and quality. Building on a series of recent larger and smaller research projects, the paper sketches the complex interactions between community involvement, water use, and hydrological processes. Catchment-wide processes (including infiltration and runoff) resulting in water retention and sustained flow in the seasonal rives need to be taken into account. At the same time, within a catchment and within communities, diversity between water users (for example in terms of access or values related to water) will be encountered. The interplays between all these different issues have to be studied in more detail, to support governments and communities developing water harvesting interventions like sand-storage dams.
When the Masks Come Off in Canada and Guatemala: Will the Realities of Racism and Marginalization of Midwives Finally Be Addressed?
Authors: Daviss Betty-Anne , Roberts Tammy , Leblanc Candace , Champet Iris , Betchi Bernadette , Ashawasegai Angela , Gamez Laura
Published: July 2021

This article addresses the effects of COVID-19 in Eastern and Northern Ontario, Canada, with a comparative glimpse at the small province of Totonicapán, Guatemala, with which Canadians have been involved in obstetric and midwifery care in particular over the last 5 years. With universal health care coverage since 1966 and well-integrated midwifery, Canada's system would be considered relatively well set up to deal with a disaster like COVID-19 compared to low resource countries like Guatemala or countries without universal health care insurance (like the USA). However, the epidemic has uncovered the fact that in Ontario, Indigenous, Black, and People of Color (IBPOC), as elsewhere, may have been hardest hit, often not by actually contracting COVID-19, but by suffering secondary consequences. While COVID-19 could be an issue through which health care professionals can come together, there are signs that the medical hierarchies in many hospitals in both Ontario and Totonicapán are taking advantage of COVID-19 to increase interventive measures in childbirth and reduce midwives' involvement in hospitals. Meanwhile, home births are on the rise in both jurisdictions. Stories from a Jamaican Muslim woman in Ottawa, an Indigenous midwifery practice in Northern Ontario, registered midwives in Eastern Ontario, and about the traditional midwives in Guatemala reveal similar as well as unique problems resulting from the lockdowns. While this article is not intended to constitute an exhaustive analysis of social justice and human rights issues in Canada and Guatemala, we do take this opportunity to demonstrate where COVID-19 has become a catalyst that challenges the standard narrative, exposing the old ruts and blind spots of inequality and discrimination that our hierarchies and inadequate data collection—until the epidemic—were managing to ignore. As health advocates, we see signs that this pandemic is resulting in more open debate, which we hope will last long after it is over in both our countries.
Equivalence, Justice, Injustice – Health and Social Care Decision Making in Relation to Prison Populations
Authors: Shepherd Andrew , Hewson Tom , Hard Jake , Green Russell , Shaw Jennifer
Published: July 2021

Prisons represent sites of singular healthcare need–characterized by high levels of distress and disorder. In many jurisdictions, practitioners are ethically charged with delivering healthcare that is “equivalent” to that available in the wider community. This claim has been much debated–yet the emergence of a global coronavirus pandemic has highlighted the arguments in a particularly stark manner. In the following conceptual analysis, we explore the emergent discourse of the coronavirus and consider its particular significance for prison healthcare decision making and the concept of equivalence. For example, both the coronavirus pandemic and practice of prison incarceration induce a sense of varied temporality: The discourse of prison is replete in this area–such as the concept of “hard time.” Alongside this, the discourse in relation to coronavirus has highlighted two competing modes of temporal understanding: The political–where the pandemic is conceptualized as has having a discrete “beginning and end”, and the scientific–where the “new normal” reflects the incorporation of the “novel” coronavirus into the wider ecology. The impact of these disparate understandings on the prison population is complex: “Locking down” prisoners–to safeguard the vulnerable against infection–is relatively simple, yet it has traumatic repercussions with respect to liberty and psychosocial health. Easing lockdown, by contrast, is a difficult endeavor and risks collision between the temporalities of prison–where “hard time” is accentuated by separation from the “real world”–the political and the scientific. Whither then the concept of equivalence in relation to a field that is definitively non-equivalent? How can practitioners and policy makers maintain a just ethical stance in relation to the allocation of resources when it comes to a politically marginalized yet manifestly vulnerable population? We argue that further debate and consideration are required in this field–and propose a framework for such discussion.
Efficacy of Yun-Type Optimized Pelvic Floor Training Therapy for Middle-Aged Women With Severe Overactive Bladder: A Randomized Clinical Trial
Authors: Shi Chaoliang , Zhou Dan , Yu Wandong , Jiao Wei , Shi Guowei , Wang Yangyun
Published: July 2021

Background: This study aimed to evaluate the clinical efficacy of Yun-type optimized pelvic floor training therapy for middle-aged women with severe overactive bladder (OAB).

Methods: This randomized, observer-blinded, parallel-group controlled clinical trial included 108 middle-age women with severe OAB and assigned them to the intervention group (treated with combination of Yun-type optimized pelvic floor training with solifenacin for 12 weeks) and control group (treated with solifenacin for 6 weeks and, after 2 weeks of elution, received the combination of Yun-type optimized pelvic floor training and solifenacin for 6 weeks). The outcomes associated with OAB, pelvic floor muscle (PFM) function, and sexual function were compared after 6 and 12/14 weeks of treatment.

Results: The primary variables were OAB-associated outcomes, including overactive bladder symptom score (OABSS), urgent urination, urine, nocturia, urge urinary incontinence, patient's perception of bladder condition, urogenital distress inventory-6, incontinence impact questionnaire-7, voiding volume, average flow rate, and maximum flow rate. The secondary variables were indicators related to PFM function and sexual function. These indicators were significantly improved in both groups after interventions. Notably, the improvements in most of these indicators were superior in the intervention group than in the control group after 6 weeks and 12/14 weeks of treatment.

Conclusions: The use of Yun-type optimized pelvic floor training adds to the benefits of solifenacin regarding severe OAB-associated outcomes, PMF function, and sexual function in middle-aged women with severe OAB. Combining Yun-type optimized pelvic floor training with traditional drug therapies may improve clinical outcomes in patients with severe OAB.

Trial Registration: ChiCTR-INR-17012189.
Can Postoperative CT Imaging in Spine Surgery Be Replaced by Intraoperative 3D Rotation With the C-Arm?: Results of a Prospective Single Center Cohort Study
Authors: Banat Mohammed , Wach Johannes , Salemdawod Abdallah , Domurath Lisa , Scorzin Jasmin , Vatter Hartmut
Published: July 2021

Objective: Dorsal instrumentation of the spine is an established treatment option for a range of spinal pathologies. Intraoperative fluoroscopy connected with navigation minimize the risk of incorrect screws placement. In several cases, post-operative CT scans are needed to verify possible mismatches. In this study, we evaluated the efficacy of 3D intraoperative fluoroscopy as compared to post-operative CT and the need of post-operative CT.

Methods: We conducted a prospective single-center cohort study, 94 patients were included. The screws were implanted using 3D rotation with C-arm and navigation system. The definitive position of the screws was verified by a post-operative CT scan. Finally, we compared the discrepance between intraoperative imaging and post-operative CT scan using Rampersaud-grade (A-D).

Results: 607 screws in 94 patients were included. Some 3% of the screws had to be replaced immediately intraoperative due to inadequate position with lateral or medial trajectory. An A-score was achieved for 85.5% of the 3D controlled screws and 87% of the post-operative CT. A B-score was found in 11.5% of either groups. In the 3D group a C-score was achieved for 2.5% and in the CT group for 0.8%. A D-score was found in 0.5% of the screws in both groups, p = 0.45. Only a mismatch of 3% could be detected for the intraoperative and post-operative imaging results.

Conclusion: Our study data shows that the placement of screws using the 3D rotation and navigation tool is safe and accurate. There were no relevant mismatches between intraoperative images and the post-operative CT.
Enhanced Detection of Mycobacterium bovis-Specific T Cells in Experimentally-Infected Cattle
Authors: Boggiatto Paola M. , Kanipe Carly R. , Palmer Mitchell V.
Published: July 2021

Bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis, continues to be a major economic burden associated with production losses and a public health concern due to its zoonotic nature. As with other intracellular pathogens, cell-mediated immunity plays an important role in the control of infection. Characterization of such responses is important for understanding the immune status of the host, and to identify mechanisms of protective immunity or immunopathology. This type of information can be important in the development of vaccination strategies, diagnostic assays, and in predicting protection or disease progression. However, the frequency of circulating M. bovis-specific T cells are often low, making the analysis of such responses difficult. As previously demonstrated in a different cattle infection model, antigenic expansion allows us to increase the frequency of antigen-specific T cells. Moreover, the concurrent assessment of cytokine production and proliferation provides a deeper understanding of the functional nature of these cells. The work presented here, analyzes the T cell response following experimental M. bovis infection in cattle via in vitro antigenic expansion and re-stimulation to characterize antigen-specific CD4, CD8, and γδ T cells and their functional phenotype, shedding light on the variable functional ability of these cells. Data gathered from these studies can help us better understand the cellular response to M. bovis infection and develop improved vaccines and diagnostic tools.
Psicoanálisis y asistencia pública en salud mental o ¿tiene algo que ver el psicoanálisis con la salud mental?
Authors: Miró Coll Maria Teresa
Published: July 2021

En este artículo la autora revisa las aportaciones del psicoanálisis a la asistencia pública en Salud Mental. La revisión recoge las contribuciones teóricas sobre la comprensión del funcionamiento mental junto a sus aplicaciones a la práctica clínica, tanto desde el aspecto del estudio de la relación terapeuta-paciente como de las diferentes técnicas psicoterapéuticas que tienen una orientación psicoanalítica.
Containment Control of First-Order Multi-Agent Systems under PI Coordination Protocol
Authors: Huang Mingyang , Liu Chenglin , Shan Liang
Published: July 2021

This paper investigates the containment control problem of discrete-time first-order multi-agent system composed of multiple leaders and followers, and we propose a proportional-integral (PI) coordination control protocol. Assume that each follower has a directed path to one leader, and we consider several cases according to different topologies composed of the followers. Under the general directed topology that has a spanning tree, the frequency-domain analysis method is used to obtain the sufficient convergence condition for the followers achieving the containment-rendezvous that all the followers reach an agreement value in the convex hull formed by the leaders. Specially, a less conservative sufficient condition is obtained for the followers under symmetric and connected topology. Furthermore, it is proved that our proposed protocol drives the followers with unconnected topology to converge to the convex hull of the leaders. Numerical examples show the correctness of the theoretical results.
A Multicriteria Simheuristic Approach for Solving a Stochastic Permutation Flow Shop Scheduling Problem
Authors: Gonzalez-Neira Eliana Maria , Montoya-Torres Jairo R. , Jimenez Jose-Fernando
Published: July 2021

This paper proposes a hybridized simheuristic approach that couples a greedy randomized adaptive search procedure (GRASP), a Monte Carlo simulation, a Pareto archived evolution strategy (PAES), and an analytic hierarchy process (AHP), in order to solve a multicriteria stochastic permutation flow shop problem with stochastic processing times and stochastic sequence-dependent setup times. For the decisional criteria, the proposed approach considers four objective functions, including two quantitative and two qualitative criteria. While the expected value and the standard deviation of the earliness/tardiness of jobs are included in the quantitative criteria to address a robust solution in a just-in-time environment, this approach also includes a qualitative assessment of the product and customer importance in order to appraise a weighted priority for each job. An experimental design was carried out in several study instances of the flow shop problem to test the effects of the processing times and sequence-dependent setup times, obtained through lognormal and uniform probability distributions with three levels of coefficients of variation, settled as 0.3, 0.4, and 0.5. The results show that both probability distributions and coefficients of variation have a significant effect on the four decision criteria selected. In addition, the analytical hierarchical process makes it possible to choose the best sequence exhibited by the Pareto frontier that adjusts more adequately to the decision-makers’ objectives.
Efficient Dynamic Cost Scheduling Algorithm for Financial Data Supply Chain
Authors: Al Sadawi Alia , Shamayleh Abdulrahim , Ndiaye Malick
Published: July 2021

The financial data supply chain is vital to the economy, especially for banks. It affects their customer service level, therefore, it is crucial to manage the scheduling of the financial data supply chain to elevate the efficiency of banking sectors’ performance. The primary tool used in the data supply chain is data batch processing which requires efficient scheduling. This work investigates the problem of scheduling the processing of tasks with non-identical sizes and different priorities on a set of parallel processors. An iterative dynamic scheduling algorithm (DCSDBP) was developed to address the data batching process. The objective is to minimize different cost types while satisfying constraints such as resources availability, customer service level, and tasks dependency relation. The algorithm proved its effectiveness by allocating tasks with higher priority and weight while taking into consideration customers’ Service Level Agreement, time, and different types of costs, which led to a lower total cost of the batching process. The developed algorithm proved effective by testing it on an illustrative network. Also, a sensitivity analysis is conducted by varying the model parameters for networks with different sizes and complexities to study their impact on the total cost and the problem under study.
Perspectives on the Sonic Environment and Noise Mitigations during the COVID-19 Pandemic Era
Authors: Lee Heow Pueh , Kumar Sanjay
Published: July 2021

The pandemic has impacted every facet of our life, society, and environment. It has also affected both the requirement and challenges for acoustic research and applications. The present article attempts to present a summary of the impact of COVID-19 on several aspects of acoustics, from the changes in the sonic environment due to reduced human and industrial activities to natural ventilation requirements for mitigating the transmission of coronavirus while mitigating noise, and, more importantly, discusses the potential impacts and challenges for acoustics in the post-COVID-19 era. The present study specifically examines the effects of COVID-19 on the sonic environment, the acoustic treatment by considering the need for constant disinfection, the noise control on construction and neighborhood activities in response to an increased number of people working from home, and the need for having natural ventilation while mitigating noise at home and offices.
Highly-Skilled Migrants, Gender, and Well-Being in the Eindhoven Region. An Intersectional Analysis
Authors: Spadavecchia Camilla , Yu Jie
Published: July 2021

The shortage of skilled labor and the global competition for highly qualified employees has challenged Dutch companies to develop strategies to attract Highly Skilled Migrants (HSMs). This paper presents a study exploring how well-being is experienced by HSMs living in the Eindhoven region, a critical Dutch Tech Hub. Our population includes highly skilled women and men who moved to Eindhoven for work or to follow their partner trajectory. By analyzing data according to these four groups, we detect significant differences among HSMs. Given the exploratory nature of this work, we use a qualitative method based on semi-structured interviews. Our findings show that gender plays a crucial role in experienced well-being for almost every dimension analyzed. Using an intersectional approach, we challenge previous models of well-being, and we detect different factors that influence the respondents’ well-being when intersecting with gender. Those factors are migratory status, the reason to migrate, parenthood, and origin (EU/non-EU). When all the factors intersect, participants’ well-being decreases in several areas: career, financial satisfaction, subjective well-being, and social relationships. Significant gender differences are also found in migration strategies. Finally, we contribute to debates about skilled migration and well-being by including an intersectional perspective.
Phenolic Response to Walnut Anthracnose (Ophiognomonia leptostyla) Infection in Different Parts of Juglans regia Husks, Using HPLC-MS/MS
Authors: Medic Aljaz , Solar Anita , Hudina Metka , Veberic Robert
Published: July 2021

This study compares the individual phenolic response of husk tissues of Juglans regia L., infected to different degrees of severity with walnut anthracnose, which is one of the most serious and widespread walnut diseases worldwide. A comparison among three differently susceptible cultivars, ‘Franquette’, ‘Milotai 10’ (‘M10’), and ‘Milotai intenziv’ (‘M10-37’), is made. In our methodology, high performance liquid chromatography coupled with mass spectrometry is used to identify and quantify the compounds. Our results show that flavanols, flavonols, and naphthoquinones account for more than 95% of the phenolic compounds identified in the walnut husk. The higher total analyzed phenolic content in tissues is more affected by walnut anthracnose confirmed that phenolics play a major role in the plant’s response against pathogens. A difference between cultivars is observed, since French cultivar ‘Franquette’ responds differently to walnut anthracnose infection than Hungarian cultivars ‘M10’ and ‘M10-37’. Naphthoquinones and flavanols have a very similar response to walnut anthracnose infection. The resistance of cultivars may be due to the reaction time of the plant and the speed with which it recognizes the pathogen and responds quickly to the infection by containing it while it has not yet spread. Flavonols may be the most important phenolic compounds in disease control, since they respond more rapidly to infection than flavanols and naphthoquinones. They also play an inhibitory role in the early stages of viral and bacterial infections.