bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 5 from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer
Authors: Cai Houjian , Memarzadeh Sanaz , Stoyanova Tanya , Beharry Zanna , Kraft Andrew S. , Witte Owen N.
Published: April 2023

PDF file, 83K, Dividing prostate spheres in Kras(G12D)+AR transduced cells.
Supplementary Table 2 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: April 2023

XLS file - 566K, Differentially-methylated CpG Loci In Each Patient Methylation Subgroup
Supplementary Figure 3 from Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer
Authors: Cai Houjian , Memarzadeh Sanaz , Stoyanova Tanya , Beharry Zanna , Kraft Andrew S. , Witte Owen N.
Published: April 2023

PDF file, 83K, IHC staining of Kras(G12D) and AR tumor tissues.
Supplementary Figure 5 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: April 2023

PDF file - 95K, Specificity analysis for survival association with neighboring gene-locus methylation
Supplementary Figure 3 from Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Poage Graham M. , Butler Rondi A. , Houseman E. Andrés , McClean Michael D. , Nelson Heather H. , Christensen Brock C. , Marsit Carmen J. , Kelsey Karl T.
Published: April 2023

PDF file - 93K, Validation of array CpG methylation data by pyrosequencing
Supplementary Tables 1-13 from 19p13.1 Is a Triple-Negative–Specific Breast Cancer Susceptibility Locus
Authors: Stevens Kristen N. , Fredericksen Zachary , Vachon Celine M. , Wang Xianshu , Margolin Sara , Lindblom Annika , Nevanlinna Heli , Greco Dario , Aittomäki Kristiina , Blomqvist Carl , Chang-Claude Jenny , Vrieling Alina , Flesch-Janys Dieter , Sinn Hans-Peter , Wang-Gohrke Shan , Nickels Stefan , Brauch Hiltrud , Ko Yon-Dschun , Fischer Hans-Peter , Schmutzler Rita K. , Meindl Alfons , Bartram Claus R. , Schott Sarah , Engel Christoph , Godwin Andrew K. , Weaver JoEllen , Pathak Harsh B. , Sharma Priyanka , Brenner Hermann , Müller Heiko , Arndt Volker , Stegmaier Christa , Miron Penelope , Yannoukakos Drakoulis , Stavropoulou Alexandra , Fountzilas George , Gogas Helen J. , Swann Ruth , Dwek Miriam , Perkins Annie , Milne Roger L. , Benítez Javier , Zamora María Pilar , Pérez José Ignacio Arias , Bojesen Stig E. , Nielsen Sune F. , Nordestgaard Børge G. , Flyger Henrik , Guénel Pascal , Truong Thérèse , Menegaux Florence , Cordina-Duverger Emilie , Burwinkel Barbara , Marmé Frederick , Schneeweiss Andreas , Sohn Christof , Sawyer Elinor , Tomlinson Ian , Kerin Michael J. , Peto Julian , Johnson Nichola , Fletcher Olivia , dos Santos Silva Isabel , Fasching Peter A. , Beckmann Matthias W. , Hartmann Arndt , Ekici Arif B. , Lophatananon Artitaya , Muir Kenneth , Puttawibul Puttisak , Wiangnon Surapon , Schmidt Marjanka K. , Broeks Annegien , Braaf Linde M. , Rosenberg Efraim H. , Hopper John L. , Apicella Carmel , Park Daniel J. , Southey Melissa C. , Swerdlow Anthony J. , Ashworth Alan , Orr Nicholas , Schoemaker Minouk J. , Anton-Culver Hoda , Ziogas Argyrios , Bernstein Leslie , Dur Christina Clarke , Shen Chen-Yang , Yu Jyh-Cherng , Hsu Huan-Ming , Hsiung Chia-Ni , Hamann Ute , Dünnebier Thomas , Rüdiger Thomas , Ulmer Hans Ulrich , Pharoah Paul P. , Dunning Alison M. , Humphreys Manjeet K. , Wang Qin , Cox Angela , Cross Simon S. , Reed Malcom W. , Hall Per , Czene Kamila , Ambrosone Christine B. , Ademuyiwa Foluso , Hwang Helena , Eccles Diana M. , Garcia-Closas Montserrat , Figueroa Jonine D. , Sherman Mark E. , Lissowska Jolanta , Devilee Peter , Seynaeve Caroline , Tollenaar Rob A.E.M. , Hooning Maartje J. , Andrulis Irene L. , Knight Julia A. , Glendon Gord , Mulligan Anna Marie , Winqvist Robert , Pylkäs Katri , Jukkola-Vuorinen Arja , Grip Mervi , John Esther M. , Miron Alexander , Alnæs Grethe Grenaker , Kristensen Vessela , Børresen-Dale Anne-Lise , Giles Graham G. , Baglietto Laura , McLean Catriona A. , Severi Gianluca , Kosel Matthew L. , Pankratz V.S. , Slager Susan , Olson Janet E. , Radice Paolo , Peterlongo Paolo , Manoukian Siranoush , Barile Monica , Lambrechts Diether , Hatse Sigrid , Dieudonne Anne-Sophie , Christiaens Marie-Rose , Chenevix-Trench Georgia , Beesley Jonathan , Chen Xiaoqing , Mannermaa Arto , Kosma Veli-Matti , Hartikainen Jaana M. , Soini Ylermi , Easton Douglas F. , Couch Fergus J.
Published: April 2023

PDF file - 272K
Supplementary Table 1 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: April 2023

PDF file - 55K
Supplementary Table 1, Figure 1 from Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers
Authors: Beloueche-Babari Mounia , Arunan Vaitha , Troy Helen , te Poele Robert H. , Te Fong Anne-Christine Wong , Jackson L. Elizabeth , Payne Geoffrey S. , Griffiths John R. , Judson Ian R. , Workman Paul , Leach Martin O. , Chung Yuen-Li
Published: April 2023

PDF file - 94K
Supplementary Figure 5 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: April 2023

PDF file - 168K
Supplementary Figure 3 from Targeting eNOS in Pancreatic Cancer
Authors: Lampson Benjamin L. , Kendall S. DiSean , Ancrile Brooke B. , Morrison Meghan M. , Shealy Michael J. , Barrientos Katharine S. , Crowe Matthew S. , Kashatus David F. , White Rebekah R. , Gurley Susan B. , Cardona Diana M. , Counter Christopher M.
Published: April 2023

PDF file - 164K, L-NAME has minimal effects on cellular proliferation in vitro
Supplementary Figure 3 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: April 2023

PDF file - 235K
Supplementary Figure 2 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: April 2023

PDF file - 455K
Supplementary Table 6 from Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Authors: Floc'h Nicolas , Kinkade Carolyn Waugh , Kobayashi Takashi , Aytes Alvaro , Lefebvre Celine , Mitrofanova Antonina , Cardiff Robert D. , Califano Andrea , Shen Michael M. , Abate-Shen Cory
Published: April 2023

DOC file, 296K, GSEA data for the intact mice.
Supplementary Table 1 from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: April 2023

PDF file - 111K, Targeting sequences of siRNA and shRNA
Supplementary Table 4 from Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Authors: Floc'h Nicolas , Kinkade Carolyn Waugh , Kobayashi Takashi , Aytes Alvaro , Lefebvre Celine , Mitrofanova Antonina , Cardiff Robert D. , Califano Andrea , Shen Michael M. , Abate-Shen Cory
Published: April 2023

XLS file, 239K, Differentially expressed gene set data for the intact mice.
Supplementary Figure 1 and Tables 1 - 3 from Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Authors: Floc'h Nicolas , Kinkade Carolyn Waugh , Kobayashi Takashi , Aytes Alvaro , Lefebvre Celine , Mitrofanova Antonina , Cardiff Robert D. , Califano Andrea , Shen Michael M. , Abate-Shen Cory
Published: April 2023

PDF file, 4581K, Supplementary Figure 1 and Table 1-3 Supp. Figure 1: Preclinical analyses of intact Nkx3.1CE2/+; Ptenf/f mice Supp. Table 1: List of primers used in this study Supp. Table 2: List of antibodies used in this study Supp. Table 3: Summary of Tumor weights and proliferation of prostate tumor from intact Nkx3.1CE2/+;Ptenf/f mice.
Supplementary Figure Legends 1-9 from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: April 2023

PDF file - 68K
Supplementary Table 5 from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: April 2023

XLS file - 142K, Genes up- and down- regulated in ESE3low tumors compared to all tumors (Q<0.05)
Supplementary Table 1 from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: April 2023

PDF file - 107K, Primer sets for RT-PCR, qRT-PCR and CHIP
Supplementary Tables 1-3 from MET Signaling Regulates Glioblastoma Stem Cells
Authors: Joo Kyeung Min , Jin Juyoun , Kim Eunhee , Ho Kim Kang , Kim Yonghyun , Gu Kang Bong , Kang Youn-Jung , Lathia Justin D. , Ho Cheong Kwang , Song Paul H. , Kim Hyunggee , Seol Ho Jun , Kong Doo-Sik , Lee Jung-Il , Rich Jeremy N. , Lee Jeongwu , Nam Do-Hyun
Published: April 2023

PDF file - 292K, Table S1 shows FACS analysis results of MET, CD133, and CD15 in the freshly isolated patient GBM cells, and Table S2 describes the list of patient-derived GBM cells and their derivatives used in this study. Patient information of 14 matched pre- and postradiated GBM specimens is shown in Table S3
Supplementary Figure 5 from Augmentation of Therapeutic Responses in Melanoma by Inhibition of IRAK-1,-4
Authors: Srivastava Ratika , Geng Degui , Liu Yingjia , Zheng Liqin , Li Zhaoyang , Joseph Mary Ann , McKenna Colleen , Bansal Navneeta , Ochoa Augusto , Davila Eduardo
Published: April 2023

PDF file - 144K, Effects of TLR stimulation and cytokines on IRAK phosphorylation in melanoma cells
Supplementary Figure 3 from An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Authors: Cho Hye Rim , Wen He , Ryu Young Jin , An Yong Jin , Kim Hyo Cheol , Moon Woo Kyung , Han Moon Hee , Park Sunghyouk , Choi Seung Hong
Published: April 2023

PDF file - 130K, Representative HR-MAS spectra of CSF with full scale lactate peak
Supplementary Figure 1 from An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Authors: Cho Hye Rim , Wen He , Ryu Young Jin , An Yong Jin , Kim Hyo Cheol , Moon Woo Kyung , Han Moon Hee , Park Sunghyouk , Choi Seung Hong
Published: April 2023

PDF file - 360K, Isolation of glioma cells expressing GFP
Supplementary Table 1 from Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis
Authors: van der Weyden Louise , Papaspyropoulos Angelos , Poulogiannis George , Rust Alistair G. , Rashid Mamunur , Adams David J. , Arends Mark J. , O'Neill Eric
Published: April 2023

PDF file - 45K, List of siRNA sequences
Supplementary Figure Legends 1-6 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: April 2023

PDF file - 31K
Supplementary Figure 6 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: April 2023

PDF file - 666K, Influence of LBW242 treatment on the activation of the intrinsic and extrinsic apoptosis pathways in MYCN amplified Kelly cells.
Supplementary Figure 1 from Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis
Authors: van der Weyden Louise , Papaspyropoulos Angelos , Poulogiannis George , Rust Alistair G. , Rashid Mamunur , Adams David J. , Arends Mark J. , O'Neill Eric
Published: April 2023

PDF file - 64K, U2OS cells were transfected with either non-targeting (NT) or siRNA RUNX2 as above, in the presence or absence of siRNA targeting RASSF1A, and endogenous YAP1 immunoprecipitates were blotted with the indicated antibodies
Supplementary Figure 4 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: April 2023

PDF file - 2.6MB, Effects of LBW242 or XIAP silencing on apoptosis induction and caspase activation in SH-EP neuroblastoma cells.
Supplementary Methods from Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7
Authors: Liu Can , Kelnar Kevin , Vlassov Alexander V. , Brown David , Wang Junchen , Tang Dean G.
Published: April 2023

PDF file - 128K
Supplementary Figure 5 from Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development
Authors: Okada Hikari , Honda Masao , Campbell Jean S. , Sakai Yoshio , Yamashita Taro , Takebuchi Yuuki , Hada Kazuhiro , Shirasaki Takayoshi , Takabatake Riuta , Nakamura Mikiko , Sunagozaka Hajime , Tanaka Takuji , Fausto Nelson , Kaneko Shuichi
Published: April 2023

PDF file - 2MB, The core gene network consisting 41 representative growth factors, receptors (PDGFR and TGFI3R etc) and transcriptional factors. Sp1 and Ap1 could be the "hub", key regulators in the network.
Supplementary Table 2 from Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Authors: Hilvo Mika , Denkert Carsten , Lehtinen Laura , Müller Berit , Brockmöller Scarlet , Seppänen-Laakso Tuulikki , Budczies Jan , Bucher Elmar , Yetukuri Laxman , Castillo Sandra , Berg Emilia , Nygren Heli , Sysi-Aho Marko , Griffin Julian L. , Fiehn Oliver , Loibl Sibylle , Richter-Ehrenstein Christiane , Radke Cornelia , Hyötyläinen Tuulia , Kallioniemi Olli , Iljin Kristiina , Orešič Matej
Published: April 2023

Supplementary Table 2 from Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Supplementary Figure Legends 1-4 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth
Authors: Luo Zhongguang , Yu Guangyang , Lee Hyuk Woo , Li Lihui , Wang Lingyan , Yang Dongqin , Pan Yongfu , Ding Chan , Qian Jing , Wu Lijun , Chu Yiwei , Yi Jing , Wang Xiangdong , Sun Yi , Jeong Lak Shin , Liu Jie , Jia Lijun
Published: April 2023

PDF file - 94K
Supplementary Tables 1-5 from Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer
Authors: Smith Steven C. , Baras Alexander S. , Owens Charles R. , Dancik Garrett , Theodorescu Dan
Published: April 2023

PDF file - 93K, Activity and expression of Ral paralogs in human cancer tissues and cell lines and listing of the genes composing the Ral expression signature used to stratify patients in our study
Supplementary Methods and Materials, Results from Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer
Authors: Smith Steven C. , Baras Alexander S. , Owens Charles R. , Dancik Garrett , Theodorescu Dan
Published: April 2023

PDF file - 44K, Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer
Supplementary Video 1 from Basal but not Luminal Mammary Epithelial Cells Require PI3K/mTOR Signaling for Ras-Driven Overgrowth
Authors: Plichta Kristin A. , Mathers Jessica L. , Gestl Shelley A. , Glick Adam B. , Gunther Edward J.
Published: April 2023

MOV file - 2MB, Live cell imaging of a K5-rtTA/TGFP organoid. Representative video depicting an organoid prepared from a Dox-na�ve basalGFP (K5-rtTA/TGFP) mouse cultured in 3D with Dox
Supplementary Figure Legend from β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma
Authors: Carbonell W. Shawn , DeLay Michael , Jahangiri Arman , Park Catherine C. , Aghi Manish K.
Published: April 2023

PDF file - 63K
Supplementary Table 1 from Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination
Authors: Aarntzen Erik H.J.G. , De Vries I. Jolanda M. , Lesterhuis W. Joost , Schuurhuis Danita , Jacobs Joannes F.M. , Bol Kalijn , Schreibelt Gerty , Mus Roel , De Wilt Johannes H.W. , Haanen John B.A.G. , Schadendorf Dirk , Croockewit Alexandra , Blokx Willeke A.M. , Van Rossum Michelle M. , Kwok William W. , Adema Gosse J. , Punt Cornelis J.A. , Figdor Carl G.
Published: April 2023

PDF file - 52K, Characteristics matched controls
Supplementary Figure 3 from Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination
Authors: Aarntzen Erik H.J.G. , De Vries I. Jolanda M. , Lesterhuis W. Joost , Schuurhuis Danita , Jacobs Joannes F.M. , Bol Kalijn , Schreibelt Gerty , Mus Roel , De Wilt Johannes H.W. , Haanen John B.A.G. , Schadendorf Dirk , Croockewit Alexandra , Blokx Willeke A.M. , Van Rossum Michelle M. , Kwok William W. , Adema Gosse J. , Punt Cornelis J.A. , Figdor Carl G.
Published: April 2023

PDF file - 34K, KLH specific responses
Supplementary Table 1 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: April 2023

PDF file - 99K, Immunostaining for Pak1 and Pak2 in mouse skin
Supplementary Figure 2 from Targeting CD4+ T-Helper Cells Improves the Induction of Antitumor Responses in Dendritic Cell–Based Vaccination
Authors: Aarntzen Erik H.J.G. , De Vries I. Jolanda M. , Lesterhuis W. Joost , Schuurhuis Danita , Jacobs Joannes F.M. , Bol Kalijn , Schreibelt Gerty , Mus Roel , De Wilt Johannes H.W. , Haanen John B.A.G. , Schadendorf Dirk , Croockewit Alexandra , Blokx Willeke A.M. , Van Rossum Michelle M. , Kwok William W. , Adema Gosse J. , Punt Cornelis J.A. , Figdor Carl G.
Published: April 2023

PDF file - 40K, Vaccine characteristics
Supplementary Methods from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: April 2023

PDF file - 153K
Supplementary Figure 4 from p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
Authors: Chow Hoi Yee , Jubb Adrian M. , Koch Jennifer N. , Jaffer Zahara M. , Stepanova Dina , Campbell David A. , Duron Sergio G. , O'Farrell Marie , Cai Kathy Q. , Klein-Szanto Andres J.P. , Gutkind J. Silvio , Hoeflich Klaus P. , Chernoff Jonathan
Published: April 2023

PDF file - 162K, Proliferation and apoptosis in drug-treated animals
Supplementary Figure 1 from Rab25 Is a Tumor Suppressor Gene with Antiangiogenic and Anti-Invasive Activities in Esophageal Squamous Cell Carcinoma
Authors: Tong Man , Chan Kwok Wah , Bao Jessie Y.J. , Wong Kai Yau , Chen Jin-Na , Kwan Pak Shing , Tang Kwan Ho , Fu Li , Qin Yan-Ru , Lok Si , Guan Xin-Yuan , Ma Stephanie
Published: April 2023

PDF file, 2272K, Expression tiling of Rab25 in 6 unpaired ESCC and non-tumor clinical samples.
Supplementary Methods from Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma
Authors: Ren Ling , Hong Sung-Hyeok , Chen Qing-Rong , Briggs Joseph , Cassavaugh Jessica , Srinivasan Satish , Lizardo Michael M. , Mendoza Arnulfo , Xia Ashley Y. , Avadhani Narayan , Khan Javed , Khanna Chand
Published: April 2023

PDF file - 67K
Supplementary Figure 6 from DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory
Authors: Raynal Noël J.-M. , Si Jiali , Taby Rodolphe F. , Gharibyan Vazganush , Ahmed Saira , Jelinek Jaroslav , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

PDf file - 300K
Supplementary Figure 4 from DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory
Authors: Raynal Noël J.-M. , Si Jiali , Taby Rodolphe F. , Gharibyan Vazganush , Ahmed Saira , Jelinek Jaroslav , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

PDF file - 204K
Supplementary Table 1 from Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/β-Catenin Pathway
Authors: Chang Po-Hao , Hwang-Verslues Wendy W. , Chang Yi-Cheng , Chen Chun-Chin , Hsiao Michael , Jeng Yung-Ming , Chang King-Jen , Lee Eva Y.-H.P. , Shew Jin-Yuh , Lee Wen-Hwa
Published: April 2023

PDF file, 22K, List of primer sequences in the study.
Supplementary Figure 6 from Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/β-Catenin Pathway
Authors: Chang Po-Hao , Hwang-Verslues Wendy W. , Chang Yi-Cheng , Chen Chun-Chin , Hsiao Michael , Jeng Yung-Ming , Chang King-Jen , Lee Eva Y.-H.P. , Shew Jin-Yuh , Lee Wen-Hwa
Published: April 2023

PDF file, 60K, High expression of Robo1 in cancer cells or Slit2 in stromal fibroblasts prevents B-catenin nuclear translocation in breast cancer specimen.
Supplementary Figure 1 from DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory
Authors: Raynal Noël J.-M. , Si Jiali , Taby Rodolphe F. , Gharibyan Vazganush , Ahmed Saira , Jelinek Jaroslav , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

PDF file - 62K
Supplementary Methods from Dmp1 Physically Interacts with p53 and Positively Regulates p53′s Stability, Nuclear Localization, and Function
Authors: Frazier Donna P. , Kendig Robert D. , Kai Fumitake , Maglic Dejan , Sugiyama Takayuki , Morgan Rachel L. , Fry Elizabeth A. , Lagedrost Sarah J. , Sui Guangchao , Inoue Kazushi
Published: April 2023

PDF file - 49K
Supplementary Methods, Figures 1 - 9 from Elevation of Receptor Tyrosine Kinases by Small Molecule AKT Inhibitors in Prostate Cancer Is Mediated by Pim-1
Authors: Cen Bo , Mahajan Sandeep , Wang Wenxue , Kraft Andrew S.
Published: April 2023

PDF file - 1094K, Supplementary Methods including antibodies, PCR primers, constructs, 7-Methyl-GTP cap binding assay, Phospho-RTK arrays, and Methionine incorporation assay. Supplementary Figure 1. AKT inhibition induces expression of Pim-1 and RTKs. Supplementary Figure 2. GSK690693 induced RTK upregulation is blocked by a Pim kinase inhibitor in prostate cancer cells. Supplementary Figure 3. Phospho-RTK array analysis of cells treated with AKT and Pim inhibitors. Supplementary Figure 4. Pim kinase inhibitors reduce the expression of RTKs. Supplementary Figure 5. RTK levels are insensitive to mTOR inhibitors. Supplementary Figure 6. Pim-1 does not control RTK mRNA expression or protein half-life. Supplementary Figure 7. Knockdown of Pim-1 suppresses GSK690693-induced MET and IGF1R IRES activities. Supplementary Figure 8. GSK690693 and SMI-4a synergistically blocks the proliferation of DU145 cells. Supplementary Figure 9. Inhibition of protein translation by GSK690693 and PP242.
Supplementary Figure 1 from Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/β-Catenin Pathway
Authors: Chang Po-Hao , Hwang-Verslues Wendy W. , Chang Yi-Cheng , Chen Chun-Chin , Hsiao Michael , Jeng Yung-Ming , Chang King-Jen , Lee Eva Y.-H.P. , Shew Jin-Yuh , Lee Wen-Hwa
Published: April 2023

PDF file, 73K, Robo1 protein expression in tumors derived from MDA-MB-231 and HCC1937 fat pad xenografts.
Supplementary Figure Legends 1-6 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Authors: Lee Min-Hyung , Jothi Mathivanan , Gudkov Andrei V. , Mal Asoke K.
Published: April 2023

Supplementary Figure Legends 1-6 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Supplementary Figure 5 from SOCS3 Transactivation by PPARγ Prevents IL-17–Driven Cancer Growth
Authors: Berger Hélène , Végran Frédérique , Chikh Madijd , Gilardi Federica , Ladoire Sylvain , Bugaut Hélène , Mignot Grégoire , Chalmin Fanny , Bruchard Mélanie , Derangère Valentin , Chevriaux Angélique , Rébé Cédric , Ryffel Bernhard , Pot Caroline , Hichami Aziz , Desvergne Béatrice , Ghiringhelli François , Apetoh Lionel
Published: April 2023

PDF file - 46K, Blockade of IL-17 by monoclonal antibody does not exert any cytotoxic effect on mammary tumor cells in vitro.
Supplementary Figure 6 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Authors: Lee Min-Hyung , Jothi Mathivanan , Gudkov Andrei V. , Mal Asoke K.
Published: April 2023

Supplementary Figure 6 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Supplementary Figure 4 from SOCS3 Transactivation by PPARγ Prevents IL-17–Driven Cancer Growth
Authors: Berger Hélène , Végran Frédérique , Chikh Madijd , Gilardi Federica , Ladoire Sylvain , Bugaut Hélène , Mignot Grégoire , Chalmin Fanny , Bruchard Mélanie , Derangère Valentin , Chevriaux Angélique , Rébé Cédric , Ryffel Bernhard , Pot Caroline , Hichami Aziz , Desvergne Béatrice , Ghiringhelli François , Apetoh Lionel
Published: April 2023

PDF file - 65K, IL-1β and IL-6 neutralization does not impair DHA in vivo effect on melanoma tumor outgrowth in competent mice.
Supplementary Figure 5 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Authors: Lee Min-Hyung , Jothi Mathivanan , Gudkov Andrei V. , Mal Asoke K.
Published: April 2023

Supplementary Figure 5 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Supplementary Figure 3 from SOCS3 Transactivation by PPARγ Prevents IL-17–Driven Cancer Growth
Authors: Berger Hélène , Végran Frédérique , Chikh Madijd , Gilardi Federica , Ladoire Sylvain , Bugaut Hélène , Mignot Grégoire , Chalmin Fanny , Bruchard Mélanie , Derangère Valentin , Chevriaux Angélique , Rébé Cédric , Ryffel Bernhard , Pot Caroline , Hichami Aziz , Desvergne Béatrice , Ghiringhelli François , Apetoh Lionel
Published: April 2023

PDF file - 50K, In vivo DHA treatment fails to prevent mammary cancer cell growth in vivo in absence of T cells.
Supplementary Figure 4 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Authors: Lee Min-Hyung , Jothi Mathivanan , Gudkov Andrei V. , Mal Asoke K.
Published: April 2023

Supplementary Figure 4 from Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
Supplementary Materials and Methods from Epigenetic Resensitization to Platinum in Ovarian Cancer
Authors: Matei Daniela , Fang Fang , Shen Changyu , Schilder Jeanne , Arnold Alesha , Zeng Yan , Berry William A. , Huang Tim , Nephew Kenneth P.
Published: April 2023

PDF file - 138K, Materials and Methods. Supplementary Table S1: Primers used for pyrosequencing Supplementary Table S2. DAVID Gene ontology (GO) enrichment analysis of differentially demethylated genes after decitabine in phase II PFS>6months vs. PFS<6months (biopsy, cut off beta>0.5; enrichment score>1.81) Supplementary Table 3. DAVID Gene ontology (GO) enrichment analysis of differentially hypermethylated genes before decitabine in phase II R (PFS>6months) vs. NR (PFS<6months) (biopsy, cut off beta>0.5; enrichment score>1.81) Figure legends: Supplementary Figure 1: LINE-1 demethylation in PBMC (A and B) and tumor biopsies (C) separated by group (PFS>6months or < 6months). Supplementary Figure 2: Full Heat Map shows all 842 unique hypermethylated genes for PFS > 6 months and 283 genes for PFS < 6 months. Methylation levels are color coded from green, β value =0, to red, β value =1. Supplementary Figure 3: Demethylation induced by decitabine in biopsy samples. (A) A map of enriched functional clusters for genes demethylated by decitabine in biopsy samples based on DAVID functional annotation clustering. The size of the bars and the circles represent the enrichment score and the gene count, respectively. Detailed information regarding lists of gene members of each cluster is provided in Supplementary Table S2. (B) The pathways enriched by unique demethylated genes in the 2 groups. Supplementary Figure 4: HOXA11 methylation levels (A) HOXA11 DNA methylation levels in patient biopsies measured by pyrosequencing on days 1 and 8. Bars/error bars represent mean +/- SD. (B) Treatment induced hypomethylation of HOXA11 in tumor biopsies in patients with PFS > 6 months vs. < 6 months (P < 0.01). Bars/error bars represent mean +/- SD. (C) Baseline methylation levels of HOXA11 in tumors or ascites correlate with PFS.
Supplementary Movie 5 from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer
Authors: Nobis Max , McGhee Ewan J. , Morton Jennifer P. , Schwarz Juliane P. , Karim Saadia A. , Quinn Jean , Edward Mike , Campbell Andrew D. , McGarry Lynn C. , Evans T.R. Jeffry , Brunton Valerie G. , Frame Margaret C. , Carragher Neil O. , Wang Yingxiao , Sansom Owen J. , Timpson Paul , Anderson Kurt I.
Published: April 2023

Supplementary Movie 5 - WMV file 1818K, Representative maximum projection SHG image of fibrillar collagen I used for GLCM analysis, plus 10 �M cylopamine
Supplementary Methods from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer
Authors: Nobis Max , McGhee Ewan J. , Morton Jennifer P. , Schwarz Juliane P. , Karim Saadia A. , Quinn Jean , Edward Mike , Campbell Andrew D. , McGarry Lynn C. , Evans T.R. Jeffry , Brunton Valerie G. , Frame Margaret C. , Carragher Neil O. , Wang Yingxiao , Sansom Owen J. , Timpson Paul , Anderson Kurt I.
Published: April 2023

Supplementary Methods - PDF file 83K, Additional experimental procedures including Multiphoton TCSPC FLIM, Frequency domain FLIM, Data Analysis, and Western Blotting
Supplementary Tables 1-2 from Cytomegalovirus Infection Leads to Pleomorphic Rhabdomyosarcomas in Trp53+/− Mice
Authors: Price Richard L. , Bingmer Katherine , Harkins Lualhati , Iwenofu O. Hans , Kwon Chang-Hyuk , Cook Charles , Pelloski Christopher , Chiocca E. Antonio
Published: April 2023

PDF file - 102K, A) Tumor age, location and type in MCMV-infected vs. Mock Trp53+/- mice. B)Summary of RMS patients' histopathology
Supplementary Figure 5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo
Authors: Raab Marc S. , Breitkreutz Iris , Anderhub Simon , Rønnest Mads H. , Leber Blanka , Larsen Thomas O. , Weiz Ludmila , Konotop Gleb , Hayden Patrick J. , Podar Klaus , Fruehauf Johannes , Nissen Felix , Mier Walter , Haberkorn Uwe , Ho Anthony D. , Goldschmidt Hartmut , Anderson Kenneth C. , Clausen Mads H. , Krämer Alwin
Published: April 2023

PDF file - 51K, GF-15 significantly increases the mitotic index in MM xenograft tumors
Supplementary Figure 3 from Cytomegalovirus Infection Leads to Pleomorphic Rhabdomyosarcomas in Trp53+/− Mice
Authors: Price Richard L. , Bingmer Katherine , Harkins Lualhati , Iwenofu O. Hans , Kwon Chang-Hyuk , Cook Charles , Pelloski Christopher , Chiocca E. Antonio
Published: April 2023

PDF file - 61K, CMV DNA in RMS
Supplementary Figure 2 from Cytomegalovirus Infection Leads to Pleomorphic Rhabdomyosarcomas in Trp53+/− Mice
Authors: Price Richard L. , Bingmer Katherine , Harkins Lualhati , Iwenofu O. Hans , Kwon Chang-Hyuk , Cook Charles , Pelloski Christopher , Chiocca E. Antonio
Published: April 2023

PDF file - 600K, Control IHC and additional HCMV IHC in human RMS
Supplementary Figure 3 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo
Authors: Raab Marc S. , Breitkreutz Iris , Anderhub Simon , Rønnest Mads H. , Leber Blanka , Larsen Thomas O. , Weiz Ludmila , Konotop Gleb , Hayden Patrick J. , Podar Klaus , Fruehauf Johannes , Nissen Felix , Mier Walter , Haberkorn Uwe , Ho Anthony D. , Goldschmidt Hartmut , Anderson Kenneth C. , Clausen Mads H. , Krämer Alwin
Published: April 2023

PDF file - 81K, HeLa-PLK4 cells treated with GF-15
Supplementary Methods, Figure Legends 1-4 from STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2
Authors: Tam Winnie F. , Hähnel Patricia S. , Schüler Andrea , Lee Benjamin H. , Okabe Rachel , Zhu Nan , Pante Saskia V. , Raffel Glen , Mercher Thomas , Wernig Gerlinde , Bockamp Ernesto , Sasca Daniel , Kreft Andreas , Robinson Gertraud W. , Hennighausen Lothar , Gilliland D. Gary , Kindler Thomas
Published: April 2023

PDF file - 91K
Supplementary Figure 2 from STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2
Authors: Tam Winnie F. , Hähnel Patricia S. , Schüler Andrea , Lee Benjamin H. , Okabe Rachel , Zhu Nan , Pante Saskia V. , Raffel Glen , Mercher Thomas , Wernig Gerlinde , Bockamp Ernesto , Sasca Daniel , Kreft Andreas , Robinson Gertraud W. , Hennighausen Lothar , Gilliland D. Gary , Kindler Thomas
Published: April 2023

PDF file - 626K, Leukemia phenotype (FACS, immunohistochemistry)
Supplementary Table 1 from Real-time Monitoring of In Vivo Acute Necrotic Cancer Cell Death Induced by Near Infrared Photoimmunotherapy Using Fluorescence Lifetime Imaging
Authors: Nakajima Takahito , Sano Kohei , Mitsunaga Makoto , Choyke Peter L. , Kobayashi Hisataka
Published: April 2023

PDF file - 40K, Gene cluster, ER, PR and p53 status of the various HER2+ breast cancer cell lines ((3) and COSMIC database)
Supplementary Figure 5 from Expression of a Truncated Active Form of VDAC1 in Lung Cancer Associates with Hypoxic Cell Survival and Correlates with Progression to Chemotherapy Resistance
Authors: Brahimi-Horn M. Christiane , Ben-Hail Danya , Ilie Marius , Gounon Pierre , Rouleau Matthieu , Hofman Véronique , Doyen Jérôme , Mari Bernard , Shoshan-Barmatz Varda , Hofman Paul , Pouysségur Jacques , Mazure Nathalie M.
Published: April 2023

PDF file - 356K
Supplementary Figure 5 from miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma
Authors: Wei Jun , Wang Fei , Kong Ling-Yuan , Xu Shuo , Doucette Tiffany , Ferguson Sherise D. , Yang Yuhui , McEnery Kayla , Jethwa Krishan , Gjyshi Olsi , Qiao Wei , Levine Nicholas B. , Lang Frederick F. , Rao Ganesh , Fuller Gregory N. , Calin George A. , Heimberger Amy B.
Published: April 2023

Supplementary Figure 5 - PDF file 77K, Up regulation of miR-124 level and down regulation of p-STAT3 in peripheral blood T-cells and glioma- infiltrating T-cells after intravenous administration of miR- 124. (A) The miR-124 expression level is below the limit of detection in CD3+ T-cells isolated from the blood of non-tumor bearing C57/BL6J mice (n = 3) and GL261-bearing mice (n = 3) ( P > 0.05). Levels are shown relative to U6 snRNA. (B) miR-124 is detected in both CD3+ T-cells isolated from blood ( P < 0.05 relative to scramble control; n=3) and gliomas ( P < 0.05 relative to scramble control; n=3) 18 hours after the in vivo administration of miR-124. (C) Coinciding with the presence of miR-124, p-STAT3 expression levels were decreased in the T-cells from the peripheral blood and gliomas in the miR-124 treated mice. Representative histograms were shown. The p-STAT3 expression levels relative to isotype control in the peripheral blood T-cells in the miR-124 treated mice (1.4 � 0.2%) was down-modulated compared to scramble treated mice (17.9 � 1.9%) ( P = 0.007; n=3) and glioma-infiltrating T-cells (miR-124: 4.3 � 0.1%; scramble: 18.2 � 4.3%; P = 0.007), but not within the splenic T-cells (miR-124: 16.8 � 0.9%; scramble: 12.9 � 2.7%; P = 0.07)
Supplementary Figure 1 from Genome-Wide Association Study of Genetic Predictors of Overall Survival for Non–Small Cell Lung Cancer in Never Smokers
Authors: Wu Xifeng , Wang Liang , Ye Yuanqing , Aakre Jeremiah A. , Pu Xia , Chang Gee-Chen , Yang Pan-Chyr , Roth Jack A. , Marks Randolph S. , Lippman Scott M. , Chang Joe Y. , Lu Charles , Deschamps Claude , Su Wu-Chou , Wang Wen-Chang , Huang Ming-Shyan , Chang David W. , Li Yan , Pankratz V. Shane , Minna John D. , Hong Waun Ki , Hildebrandt Michelle A.T. , Hsiung Chao Agnes , Yang Ping
Published: April 2023

PDF file - 587K, Manhattan Plot.
Supplementary Figure 3 from PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
Authors: Kavela Sridhar , Shinde Swapnil R. , Ratheesh Raman , Viswakalyan Kotapalli , Bashyam Murali D. , Gowrishankar Swarnalata , Vamsy Mohana , Pattnaik Sujit , Rao Subramanyeshwar , Sastry Regulagadda A. , Srinivasulu Mukta , Chen Junjie , Maddika Subbareddy
Published: April 2023

PDF file - 214K, PNUTS control Akt activation and apoptosis
Supplementary Figure 1 from PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
Authors: Kavela Sridhar , Shinde Swapnil R. , Ratheesh Raman , Viswakalyan Kotapalli , Bashyam Murali D. , Gowrishankar Swarnalata , Vamsy Mohana , Pattnaik Sujit , Rao Subramanyeshwar , Sastry Regulagadda A. , Srinivasulu Mukta , Chen Junjie , Maddika Subbareddy
Published: April 2023

PDF file - 300K, Effect of PNUTS interaction on PTEN localization and stability
Supplementary Table 4 from Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci
Authors: Hutter Carolyn M. , Chang-Claude Jenny , Slattery Martha L. , Pflugeisen Bethann M. , Lin Yi , Duggan David , Nan Hongmei , Lemire Mathieu , Rangrej Jagadish , Figueiredo Jane C. , Jiao Shuo , Harrison Tabitha A. , Liu Yan , Chen Lin S. , Stelling Deanna L. , Warnick Greg S. , Hoffmeister Michael , Küry Sébastien , Fuchs Charles S. , Giovannucci Edward , Hazra Aditi , Kraft Peter , Hunter David J. , Gallinger Steven , Zanke Brent W. , Brenner Hermann , Frank Bernd , Ma Jing , Ulrich Cornelia M. , White Emily , Newcomb Polly A. , Kooperberg Charles , LaCroix Andrea Z. , Prentice Ross L. , Jackson Rebecca D. , Schoen Robert E. , Chanock Stephen J. , Berndt Sonja I. , Hayes Richard B. , Caan Bette J. , Potter John D. , Hsu Li , Bézieau Stéphane , Chan Andrew T. , Hudson Thomas J. , Peters Ulrike
Published: April 2023

PDF file - 77K, All GxE interaction results.
Supplementary Figure 3 from Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
Authors: Zhang Yaqing , Morris John P. , Yan Wei , Schofield Heather K. , Gurney Austin , Simeone Diane M. , Millar Sarah E. , Hoey Timothy , Hebrok Matthias , Pasca di Magliano Marina
Published: April 2023

PDF file - 879K, Supplemental Figure 3. PAS, Gomori Trichrome and Claudin18 IHC staining in KC and KDC pancreas.
Supplementary Figure 2 from Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell–Based Vaccination in Metastatic Melanoma
Authors: Aarntzen Erik H.J.G. , Bol Kalijn , Schreibelt Gerty , Jacobs Joannes F.M. , Lesterhuis W. Joost , Van Rossum Michelle M. , Adema Gosse J. , Figdor Carl G. , Punt Cornelis J.A. , De Vries I. Jolanda M.
Published: April 2023

PDF file - 233K, Definition of criteria for SKIL culture evaluation: Three examples are shown to illustrate the definition of SKIL culture criteria. (A) Criterion III, one patient (IV-B-16-St) with a clear population of TAA-specific CD8+ T cells in SKIL cultures, which produce high levels of IFNg upon encounter of both the defined gp100 peptides and naturally processed gp100 presented by a HLA-A*02:01 positive melanoma cell line (Mel624). Moderate amounts of IL-2 are produced and minimal production of IL-5, representing a clear IFNg dominant cytokine profile. (B) Criterion II, a patient (IV-B-11-Ro) with TAA-specific CD8+ T cells in SKIL cultures which produce high levels of IFNg and IL-2 upon encounter of the gp100 peptide, but fail to recognize the naturally processed gp100. (C) Criterion I, a patient (IV-A-07-Th) with a population of TAA-specific CD8+ T cells in SKIL cultures, recognizing the g100-154 peptide, but not the naturally processed gp100. Furthermore, those TAA-specific CD8+ T cells do not produce IFNg but produce elevated levels of IL-5 instead, indicating that the immune system is skewed towards tumor tolerance
Supplementary Methods, Tables 1-3, Figure 1 from Inactivating All Three Rb Family Pocket Proteins Is Insufficient to Initiate Cervical Cancer
Authors: Shin Myeong-Kyun , Sage Julien , Lambert Paul F.
Published: April 2023

PDF file - 370K, Genetic crosses used in this study. Supplemental Table 1: Histopathology summary in cervix for the both Rb and p107 conditionally deficient mice treated with estrogen for 6 months. (Without treatment of TAM). Supplemental Table 2:Histopathology summary in vagina for the both pRb and p130 conditionally deficient mice treated with estrogen for 6 months. Supplemental Table 3:Histopathology summary in vagina for the pRb/p107, pRb/p107/p130conditionally deficient mice treated with estrogen for 6 months. Figure S1. Evaluation of BrdU-incorporation in cervical epithelium of estrogen-treated mice.
Supplementary Tables 1-8 from The Antioxidant Tempol Reduces Carcinogenesis and Enhances Survival in Mice When Administered after Nonlethal Total Body Radiation
Authors: Mitchell James B. , Anver Miriam R. , Sowers Anastasia L. , Rosenberg Philip S. , Figueroa Maria , Thetford Angela , Krishna Murali C. , Albert Paul S. , Cook John A.
Published: April 2023

PDF file - 125KB, Supplemental Table 1. CBA Tumor Spectrum of Major Malignant HN and Non-HN Supplemental Table 2. C3H Major Tumor Spectrum of of Major Malignant HN and Non-HN Supplemental Table 3. Incidence and Mean Survival of CBA with Hepatocellular Tumors Supplemental Table 4. Incidence and Mean Survival of C3H with Hepatocellular Tumors Supplemental Table 5. Ratio of HN to Non-HN Supplemental Table 6. Relative Hazard (RH) Ratios for CBA Mice Supplemental Table 7. Relative Hazard (RH) Ratios for C3H Mice Supplemental Table 8. Gene Expression and Onotology Classification
Supplementary Table 1 from BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Authors: Lee Jae-Ho , Lee Geun Taek , Woo Seung Hyo , Ha Yun-Sok , Kwon Seok Joo , Kim Wun-Jae , Kim Isaac Yi
Published: April 2023

Supplementary Table 1 - PDF file 56K, PCR primer sequences
Supplementary Figure 3 from CD73-Deficient Mice Are Resistant to Carcinogenesis
Authors: Stagg John , Beavis Paul A. , Divisekera Upulie , Liu Mira C.P. , Möller Andreas , Darcy Phillip K. , Smyth Mark J.
Published: April 2023

PDF file - 2.5MB
Supplementary Figures from BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Authors: Lee Jae-Ho , Lee Geun Taek , Woo Seung Hyo , Ha Yun-Sok , Kwon Seok Joo , Kim Wun-Jae , Kim Isaac Yi
Published: April 2023

Supplementary Figures- PDF file 786K, Supplementary Data and Figures
Supplementary Text from Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors
Authors: Duraiswamy Jaikumar , Kaluza Karen M. , Freeman Gordon J. , Coukos George
Published: April 2023

Supplementary Text - PDF file 121K, Supplementary Methods and Figure Legends
Supplementary Information from HMGA2 Is a Driver of Tumor Metastasis
Authors: Morishita Asahiro , Zaidi M. Raza , Mitoro Akira , Sankarasharma Devipriya , Szabolcs Matthias , Okada Yasunori , D'Armiento Jeanine , Chada Kiran
Published: April 2023

Supplementary Information - PDF file 81K, Supplementary Figure Legends and Supplementary Materials and Methods
Supplementary Table 1 from Fibulin-3 Promotes Glioma Growth and Resistance through a Novel Paracrine Regulation of Notch Signaling
Authors: Hu Bin , Nandhu Mohan S. , Sim Hosung , Agudelo-Garcia Paula A. , Saldivar Joshua C. , Dolan Claire E. , Mora Maria E. , Nuovo Gerard J. , Cole Susan E. , Viapiano Mariano S.
Published: April 2023

PDF file - 64K, List of antibodies used
Supplementary Figure 2 from HMGA2 Is a Driver of Tumor Metastasis
Authors: Morishita Asahiro , Zaidi M. Raza , Mitoro Akira , Sankarasharma Devipriya , Szabolcs Matthias , Okada Yasunori , D'Armiento Jeanine , Chada Kiran
Published: April 2023

Supplementary Figure 2 - PDF file 77K, Agarose Colony Formation Assay. Anchorage-independent proliferation was performed by plating SW403, HT29, SW620, SW480 and HCT116 (1000 cells per well) in six-well plates, with a bottom layer of 0.6% agar and a top layer of 0.3% agar containing the cells. After 21 days incubation, colonies were counted
Supplementary Figure 1 from HMGA2 Is a Driver of Tumor Metastasis
Authors: Morishita Asahiro , Zaidi M. Raza , Mitoro Akira , Sankarasharma Devipriya , Szabolcs Matthias , Okada Yasunori , D'Armiento Jeanine , Chada Kiran
Published: April 2023

Supplementary Figure 1 - PDF file 220K, Immunohistochemical analyzes of HMGA2 expression are shown (40x). These are representative sections from staining performed on patient tumor samples described in Table 1. Scale bars represent 250 microm
Supplementary Figure 6 from Fibulin-3 Promotes Glioma Growth and Resistance through a Novel Paracrine Regulation of Notch Signaling
Authors: Hu Bin , Nandhu Mohan S. , Sim Hosung , Agudelo-Garcia Paula A. , Saldivar Joshua C. , Dolan Claire E. , Mora Maria E. , Nuovo Gerard J. , Cole Susan E. , Viapiano Mariano S.
Published: April 2023

PDF file - 1.5MB, Knockdown of fibulin-3 in the tumor downregulates Notch-dependent genes and increases apoptosis