bluuebunny/crossref_metadata_2025 huggingface dataset:
De novo formation of twig-like middle cerebral artery: An illustrative case
Authors: Kajita Michihide , Yanaka Kiyoyuki , Hanai Sho , Aiyama Hitoshi , Takahashi Nobuyuki , Saiki Shinji , Ishikawa Eiichi
Published: June 2023

Background:

Twig-like middle cerebral artery (T-MCA) is a rare vascular abnormality characterized by the replacement of the M1 segment of the middle cerebral artery (MCA) with a plexiform arterial network of small vessels. T-MCA is generally regarded as an embryological persistence. Conversely, T-MCA may also be a secondary sequela but no reports of cases of de novo formation exist. Here, we report the first case describing possible de novo T-MCA formation.

Case Description:

A 41-year-old woman was referred to our hospital from a nearby clinic because of transient left hemiparesis. Magnetic resonance (MR) imaging revealed mild stenosis of the bilateral MCAs. The patient then underwent MR imaging follow-ups once a year. MR imaging at the age of 53 showed a right M1 occlusion. Cerebral angiography revealed a right M1 occlusion and formation of a plexiform network consistent with the occlusion site, leading to the diagnosis of de novo T-MCA.

Conclusion:

This is the first case report describing possible de novo T-MCA formation. Although a detailed laboratory examination did not confirm the etiology, autoimmune disease was suspected to have precipitated this vascular lesion.
Basal Cell Carcinoma Arising From a Nonhealing Lower Extremity Ulcer: A Case Report
Authors: Deen Sidra , Asad Usman , Poythress Edward
Published: June 2023

Introduction. BCC is a malignancy that arises from the basal cells of the epidermis. Despite being the most common cancer worldwide, it rarely occurs in the setting of long-standing ulceration. Malignant transformation of wounds and scars is typically associated with the development of SCC, as with an MU. Reports in the literature of BCC arising within nonhealing, lower extremity wounds are limited. Case Report. The authors report a case of a 65-year-old man with several comorbidities who presented to the clinic with a nonhealing wound on the right lateral ankle. The wound first began as warts during childhood that had necessitated frequent debridement. The lesions persisted and, 7 years ago, developed into an ulcer with a large fungating mass associated with pain, bleeding, and foul-smelling exudate. Biopsy findings were consistent with infiltrative-type BCC. He was not a surgical candidate given his comorbidities and was instead treated with radiation therapy. No evidence of metastasis was seen on follow-up imaging. Conclusion. This case highlights the importance of prompt biopsy and cultures in patients with suspicious ulcers and wounds that do not respond to appropriate treatment.
POSTHUMOUS DONATION AND ORGAN TRANSPLANTATION IN UKRAINE DURING THE WAR
Authors: MATOLINETS N.V. , DUBROV S.O. , OVECHKO M.E. , SAMCHUK O.O.
Published: June 2023

One of the leading directions of the development of Ukrainian medicine during the last few years is organ transplantation, because it is a treatment method that remains the last hope when all other methods are already ineffective. However, despite the successes in this area, there are also problematic moments, the main of which is the lack of donor organs. And the reason for this shortage is considered to be the disapproval of relatives for the removal of organs, due to the low level of awareness of the procedure for establishing brain death. But, despite this, as well as in spite of the difficult working conditions during the war, Ukrainian transplantology is constantly developing, as evidenced by the data of the Ministry of Health and the Ukrainian Center for Transplant Coordination. A significant success in the field of transplantology is the second lung transplant recently carried out in Ukraine and the first carried out independently by Ukrainian doctors.
PATIENT MONITORING DURING PROCEDURAL SEDATION: ARE THE MODERN STANDARDS IMPLEMENTED IN UKRAINE?
Authors: BIELKA K. , FRANK M. , KUCHYN I. , DIDENKO M. , SEMENKO N.
Published: June 2023

The purpose of the study was to review modern recommendations regarding the monitoring of patients during procedural sedation and analgesia as well as to assess its conformity to the modern standards in Ukraine.

Materials and methods. Recommendations from European, American, British and Australian organizations which cover the topic of procedural sedation and analgesia or levels of anesthesia that conform to the procedural sedation corresponding to ASA, the standard monitoring during anesthesia, and were published between 2003 and 2023 have been reviewed. From 17 till 20th of March a survey has been conducted. Throughout the survey, participants have anonymously filled a questionnaire via Google-Form. The link to the questionnaire was shared by the Department of Anesthesiology and Intensive Care of the Institute of Postgraduate Education of Bogomolets National University with support provided by Association of Anesthesiologists of Ukraine through social networks such as Facebook and Instagram on the official pages of the Department of Surgery, Anesthesiology, and Intensive Care of the Institute of Postgraduate Education of the Bogomolets National Medical University.

Results. A total of 284 doctors took part in the survey. Among them 280 (98.5 %) have been working in Ukraine during the survey, 4 (1.5 %) have been excluded from the analysis. Pulse oximetry was regularly used by 278 (99.2 %), automatic arterial pressure measurement by 222 (79.4 %), manual measurement of arterial pressure by 35 (12.5 %), ECG-monitoring by 95 (34.2 %), capnography by 35 (12.5 %), thermometry by 10 (3.5 %), electroencephalography by 4 (1.6 %) of the doctors (Fig. 3). 36 (12.8 %) of the respondents have informed about the absence of technical means to conduct ECG-monitoring, 172 (62.5 %) have conducted it in a selective manner. The results are presented in form of descriptive statistics and diagrams.

Conclusion. Procedural sedation is a safe method provided that modern safety standards are systematically followed. Full monitoring is a prerequisite for timely response to critical events and mitigation of their consequences. Reporting problems of any degree of criticality that occurred during sedation helps to optimize local practices and has a positive effect on the quality of medical care. Introduction of routine capnography, electrocardiography and thermometry are prioritized goals when it comes to increasing the quality of monitoring in Ukraine.
PAIN INTENSITY OF PATIENTS DURING REHABILITATION AFTER MINE BLAST WOUNDS
Authors: HOROSHKO V.R. , KUCHYN IU.L.
Published: June 2023

In 83.3 % of cases, patients who received mine blast wounds suffer from chronic pain. Such injuries are characterized by significant damage. Data on the treatment of pain during rehabilitation are presented by several clinical cases. Therefore, a broader coverage of this issue will be of some importance for the perspective of further research in this direction.

The goal of the work. To investigate the results of pain treatment in patients after mine blast wounds at the rehabilitation stage.

Methods. The treatment of 280 patients with mine blast wounds during rehabilitation was analyzed. The intensity of pain was diagnosed using a visual analog scale. Statistical methods: Shapiro-Wilk, Mann-Whitney, Friedman, chi-square, Bonferroni corrections, absolute frequency of the symptom and relative frequency (%). When analyzing the data in all cases, the critical significance level was 0.05.

Results. Patients after mine blast wounds, both at the time of discharge from inpatient treatment and during rehabilitation, still experienced pain intensity of 2 points, which in the future transformed into chronic pain. After 1, 3 and 6 months after treatment, it was found that the intensity of pain in groups 1 and 2 did not differ statistically (р=0.488, р=0.876, р=0.165, respectively), but after 12 months – statistically differed (р=0.035) and in group 2 were higher than in group 1.

Conclusions. Based on the obtained data, it can be concluded that during discharge from inpatient treatment, rehabilitation and within 12 months after treatment, the patients felt pain, albeit weak. The lack of further effective treatment can cause a whole cascade of negative consequences.
MANAGEMENT OF SEVERE PERIOPERATIVE BLEEDING
Authors: CHERNIAIEV S. , DUBROV S.
Published: June 2023

Introduction. Perioperative bleeding remains a major complication during and after surgery, leading to increased morbidity and mortality. Its prevalence depends on numerous factors affecting the hemostasis system.

Objective. Review of updated guidelines for the perioperative management of patients with severe bleeding

Conclusions. Management of perioperative bleeding involves multiple assessments and strategies to ensure appropriate patient care. First of all, it is important to identify a group of patients with an increased risk of perioperative bleeding. Strategies to correct preoperative anemia and stabilize macro- and microcirculation should then be employed to optimize the patient's bleeding tolerance. Finally, targeted interventions should be used to reduce intraoperative and postoperative bleeding, and thus to reduce subsequent morbidity and mortality.
Lipid Landscapes: Vibrational Spectroscopy for Decoding Membrane Complexity
Authors: Chen Xiaobing , Al-Mualem Ziareena , Baiz Carlos
Published: June 2023

Cell membranes are incredibly complex environments containing hundreds of components. Despite substantial advances in the past decade, fundamental questions related to lipid-lipid interactions and heterogeneity persist. This review explores the complexity of lipid membranes, showcasing recent advances in vibrational spectroscopy to characterize the structure, dynamics, and interactions at the membrane interface. We include an overview of modern techniques such as surface-enhanced infrared spectroscopy (SEIRAS) as a steady-state technique with single-bilayer sensitivity, two-dimensional sum-frequency generation (2D SFG) spectroscopy, and two-dimensional infrared (2D IR) spectroscopy to measure time-evolving structures and dynamics with femtosecond time resolution. Furthermore, we discuss the potential of multiscale MD simulations, focusing on recently developed simulation algorithms which have emerged as a powerful approach to interpret complex spectra. We highlight persistent challenges in accurately sampling heterogeneous ensembles in multicomponent membranes. Overall, this review provides an up-to-date comprehensive overview of the powerful combination of vibrational spectroscopy and simulations to illuminate lipid-lipid, lipid-protein, and lipid-water interactions in the intricate conformational landscape of cell membranes.
Number of sites based solver for determining coverages from steady-state mean-field micro-kinetic models
Authors: Vijay Sudarshan , Heenen Hendrik , Singh Aayush , Chan Karen , Voss Johannes
Published: June 2023

Kinetic models parameterised by ab-initio calculations have led to significant improvements in understanding chemical reactions in heterogeneous catalysis. These studies have been facilitated by implementations which determine steady-state coverages and rates of mean-field micro-kinetic models. As implemented in the open-source kinetic modelling program, CatMAP, the conventional solution strategy is to use a root-finding algorithm to determine the coverage of all intermediates through the steady-state expressions, constraining all coverages to be non-negative and to properly sum to unity. Though intuitive, this root-finding strategy causes issues with convergence to solution due to these imposed constraints. In this work, we avoid explicitly imposing these constraints, solving the mean-field steady-state micro-kinetic model in the space of number of sites instead of solving it in the space of coverages. We transform the constrained root-finding problem to an unconstrained least-squares minimisation problem, leading to significantly improved convergence in solving micro-kinetic models and thus enabling the eﬀicient study of more complex catalytic reactions.
Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols
Authors: Peslalz Philipp , Kraus Frank , Izzo Flavia , Bleisch Anton , El Hamdaoui Yamina , Schulz Ina , Kany Andreas , Hirsch Anna , Friedland Kristina , Plietker Bernd
Published: June 2023

The selective modulation of TRPC6 ion channels has emerged as a promising therapeutic approach for treating neuro-degenerative diseases and depression. Here, we present a significant advancement in this field by demonstrating the se-lective activation of TRPC6 using a metallated type-B PPAP, designated as PPAP53. The success of PPAP53 is attributed to the utilization of the 1,3-diketone motif present in PPAPs for metal coordination. The metallated PPAPs exhibit water solubility and equipotent activity compared to hyperforin, which is a natural product and considered the gold standard in the field. Notably, and in sharp contrast to type-A PPAPs, type-B PPAPs possess unique properties such as synthetic ac-cessibility in gram scale, facile derivatization, being thermally stable and stable against photochemical oxidation. Our detailed investigations reveal that PPAP53 selectively binds to the C-terminus of TRPC6. Although cryo electron micros-copy has resolved the majority of the TRPC6 structure, the binding site in the C-terminus remained unresolved. To ad-dress this issue, we employed state-of-the-art artificial intelligence-based protein structure prediction algorithms, includ-ing AlphaFold2, ColabFold, and trRosetta, to predict the missing C-terminus region. Our computational results, validated against experimental data, indicate that PPAP53 binds to the 777LLKL780-region of the C-terminus, thus providing critical insights into the binding mechanism of PPAP53 with TRPC6.
Fluorosulfate as a Latent Sulfate in Peptides and Proteins
Authors: Liu Chao , Liu Xueyi , Zhou Mi , Xia Chaoshuang , Soni Chintan , Zhou Zefeng , Wu Yujia , Chatterjee Abhishek , Lin Cheng , Niu Jia
Published: June 2023

Sulfation widely exists in the eukaryotic proteome. However, understanding of the biological functions of sulfation in peptides and proteins has been hampered by the lack of methods to control its spatial or temporal distribution in the proteome. Herein, we report that fluorosulfotyrosine can serve as a latent precursor of sulfotyrosine in peptides and proteins, which can be efficiently converted into sulfotyrosine residues by hydroxamic acid activators under physiologically relevant conditions. Photocaging the hydroxamic acid activators further allowed for light-controlled activation of functional sulfopeptides. This work provides a valuable tool for probing functional roles of sulfation in the peptides and proteins.
Numerical study of particle retention in water-saturated porous media and the effect of particle concentration
Authors: Sun Dan
Published: June 2023

The transport and retention of particles in slurry passing through porous media causes particle clogging, which is affected primarily by the ratio of the particle diameter to pore-throat size of the porous media. A previous study reported that the particle retention is affected by both the Stokes number and particle concentration. Therefore, this study investigates the effect of the diameter and concentration of particles on particle clogging in porous media. Furthermore, the effect of fluid velocity on particle clogging and permeability of the porous media is also investigated to study particle transport and retention in homogeneous porous media. Fluid-particle two-phase flow in porous media is numerically simulated using the computational fluid dynamics-discrete element method. Particle clogging can be directly precited via the interaction between the particles and surface of the porous media by tracing the exact location of each particle. The simulation reveals that an increase of the particle concentration increases the possibility of the particles being retained in the porous media. Additionally, particles are accumulated at the entrance region of the porous media when the particle concentration is high in the dense region.
Radical Group Transfer of Vinyl and Alkynyl Silanes Driven by Photoredox Catalysis
Authors: Baussière Floriane , Haugland Marius Myreng
Published: June 2023

Radical group transfer is a powerful tool for the formation of C–C bonds. These processes typically involve radical addition to C–C π bonds, followed by fragmentation of the cyclic intermediate. Despite the advantageous lability of organosilanes in this context, silicon-tethered radical acceptor groups have remained underexplored in radical group transfer reactions. We report a general photoredox-catalyzed protocol for the radical group transfer of vinyl and alkynyl silanes onto sp3 carbons, using activated and unactivated iodides as radical precursors. Our method displays high diastereoselectivity and excellent functional group tolerance. Mechanistic investigations revealed the key role played by silicon in facilitating a single-electron oxidation step, which leads to direct ring-opening and an overall redox-neutral process.
Anticoagulant rodenticide novel candidates predicted by evolutionary docking
Authors: coll julio
Published: June 2023

The evolutionary docking generation of high numbers of potentially novel anticoagulant rodenticides is described here. In particular, made-on-demand libraries were generated by randomly introducing small molecular variations into alphafold-modeled brodifacoum-rat VKORC1 binding-cavity. For evolution of the brodifacoum parent, criteria were mainly optimized to fit-dock the brodifacoum cavity. Libraries of specific brodifacoum-children were selected by pooling those predicting higher affinities (lower binding-scores) at various molecular weights. The selected brodifacoum-children were filtered for known toxicities, desirable high affinity to recently identified spanish resistance rat mutants and undesirable high affinities to human VKORC1. The flexible threshold-adjustable new chemotype brodifacoum-children libraries constitute an step forward towards further in silico fine-tuning to computationally reduce other possible unspecific off-target ecological impacts
Deconvoluting charge-transfer, mass transfer, and ohmic resistances in phosphonic acid-sulfonic acid ionomer binders used in electrochemical hydrogen pumps
Authors: Arunagiri Karthik , Wong Andrew Jark-Wah , Briceno-Mena Luis A. , Romagnoli José A. , Janik Michael J. , Arges Christopher G.
Published: June 2023

Ion-pair high-temperature polymer electrolyte membranes (HT-PEMs) paired with phosphonic acid ionomer electrode binders have substantially improved the performance of HT-PEM electrochemical hydrogen pumps (EHPs) and fuel cells. Recently, blending poly(pentafluorstyrene-co-tetrafluorostyrene phosphonic acid) (PTFSPA) with NafionTM, and using this blend as an electrode binder, improved proton conductivity in the electrode layer resulting in a 2 W.cm-2 peak power density of fuel cells at 240 °C (a HT-PEM fuel cell record). However, much is unknown about how phosphonic acid ionomers blended with perfluorosulfonic acid materials affect electrode kinetics and gas transport in porous electrodes. In this work, we studied the proton conductivity, electrode kinetics, and gas transport resistances of 3 types of phosphonic acid ionomers, poly(vinyl phosphonic acid), poly(vinyl benzyl phosphonic acid), and PTFSPA by themselves and when blended with Aquivion® (a perfluorosulfonic acid material). These studies were performed using EHP platforms. For all phosphoric acid ionomer types, the addition of Aquivion® promoted ionic conductivity, hydrogen oxidation/evolution reaction kinetics (HOR/HER), and hydrogen gas permeability. Solid-state 31P NMR revealed that the addition of Aquivion® eliminated or significantly reduced phosphate ester formation in phosphoric acid ionomers and this plays a vital role in enhancing ionomer blend conductivity. Using the best blend variant, PTFSPA-Aquivion®, an EHP performance of 5.1 A cm-2 at 0.4 V at T = 200 °C was attained. Density functional theory (DFT) calculations identified that phosphonic acids with electron-withdrawing moieties reduced the propensity of the phosphonic acid to specifically adsorb on platinum electrocatalyst surfaces. The relative adsorption affinity of the various phosphonic acid ionomers from DFT is consistent with an experimentally obtained charge transfer resistance. A voltage loss breakdown model revealed that the addition of Aquivion® reduced activation and concentration overpotentials in EHPs. Overall, a systematic experimental and modeling approach provided further insight as to how perfluorosulfonic acid ionomers blended with phosphoric acid ionomers affect ionic conductivity, reaction kinetics, and gas permeability in EHP platforms.
Enhancing Inhibition of Both α-Synuclein Aggregation and Neuroinflammation: New Insights into the C-9 Modification of Doxycycline
Authors: Rose Clémence , Tomas-Grau Rodrigo Hernán , Zabala Brenda , Brunel Jean-Michel , Michel Patrick P. , Chehin Rosana , Raisman-Vozari Rita , Ferrié Laurent , Figadère Bruno
Published: June 2023

Doxycycline, a semi-synthetic tetracycline, is a widely used antibiotic for mild-to-moderate infections. However, its pleiotropic effects, such as anti-inflammatory and antioxidant properties, combined with its ability to interfere with α-synuclein inhibiting its aggregation, make it an attractive candidate for repositioning in Parkinson's disease treatment. Nevertheless, the antibiotic activity of doxycycline restricts its potential for long-term treatment of Parkinsonian patients. Eighteen novel doxycycline derivatives were designed with substitution at C9. Specifically, the dimethyl-amino group at C4 was reduced to significantly diminish the antibiotic activity, and several coupling reactions were performed at position C9 of the D ring. Using biophysical models, we found that seven compounds were more effective than the parent compound in inhibiting α-synuclein aggregation. Furthermore, two of these derivatives exhibited better anti-inflammatory effects at non-cytotoxic concentrations on microglial cell culture. Thus, we identified two design-based tetracyclines as the most promising candidates for further preclinical investigations. In addition, our study provides new insights into the structure-activity relationship of tetracyclines as neuroprotective molecules.
Test
Authors: A Anandh
Published: June 2023

Check with this article.
DETERMINATION OF THE MANIFESTATION OF PSYCHOLOGICAL PROTECTION AND COPING BEHAVIOR IN STUDENTS OF 1-4 COURSES
Authors: Valentina Khomitska , Vitaliy Pidlubny , Dmytro Lashkul , Valentina Zubko
Published: June 2023

The aim is to determine the manifestation of psychological protection and the use of coping strategies to overcome difficult life situations in 1st and 4th year students. Material and methods. 60 students of the National University of Food Technologies were examined: 1st year students – 30 (50%), 4th year students – 30 (50%) individuals. To determine the manifestation of psychological protection in students, the questionnaire method "Life Style Index" by R. Plutchyk, H. Kellerman (Life Style Index, LSI) was used. Results. The following coping strategies prevail among first-year students: confrontational coping (33.3%), search for social support (20%), self-control (10%). Among the mechanisms of psychological protection are substitution (26.67%), displacement (16.67%) and denial (23.33%). High self-control (23.3%), acceptance of responsibility (20%) and problem-oriented coping (16.67%) prevail among students of the 4th year. Such psychological defense mechanisms as compensation (26.67%), hypercompensation (17%), and rationalization (13.33%) dominate. Conclusions. According to the results of the research, students of the 1st year are characterized by avoiding a difficult situation and shifting responsibility to others, while students of the 4th year are characterized by analyzing and solving a difficult situation. Among the mechanisms of psychological protection for students of the 1st year, substitution prevails, for students of the 4th year - compensation
SELF- PORTRAITS REGARDED AS THE VERY MANIFESTATION OF PSYCHOLOGICAL EVALUATION
Authors: Sah Jagati Srishti , Shukla Annpurna
Published: June 2023

The artists who are both consciously and unconsciously involved embody their very own existence with impressions from their internal life. Out of many theories psychoanalysis can be used subjectively, for the existence of an individual in the process of becoming ‘I’. This theory of unconscious could be very personal. Using the impressions from the very theories of Freud is what I would like to write about in this research paper. His theory about psychoanalysis very particularly to study oneself or someone else would be like to ask for: What to see? What to Hear or Speak about? Express or repress? Depending upon a close observation alongside awareness on the life of many artists. Which has revealed from the past as they have been instinctive believers, of some other world. Making an apt sense of this is how any repressed emotions arises when explored to a deeper level of unconscious. As ‘I’ becomes the foundation to the core body the mind actively takes the possession to take actions for that very individual with holding a command on the body. The very idea of the Identity of the artist as an individual is related deeply to what the artist’s trying to express himself/ herself as one individual. And painting is the freedom of a platform using medium to paint without any restrictions. This paper tends to study the very idea of psychological journey of the artist. With the self-portraits inducing the very Identity of the artist through a critical evaluation on the artist.
Profile of Student’s Cultural Concern Through Science Learning Based on Pacu Jalur Kuantan Singingi
Authors: Febrian Andika , Rahmawati Andi , Wilujeng Insih , Prasetyo Zuhdan Kun , Nugroho Sofyan Dwi
Published: June 2023

Science is a lesson that discusses various natural phenomena scientifically and systematically in life. Along with the times, science has undergone many transformations in improving the quality of learning, one of which is local culture-based science learning. The rapid flow of globalization of foreign cultures that enter Indonesia, making the youth generation begin to forget local culture as a noble identity. This study aims to see the effect of local culture-based science learning on the profile of cultural awareness of junior high school students. The research method used is quantitative research by giving post-test to two different classes that have implemented the learning. The two classes consisted of 31 people in the modeling class and 29 people in the implementation class. The sampling technique used was cluster random sampling. The results obtained were then analyzed and discussed descriptively quantitatively. The results show that the application of Kuantan Singingi Pacu Jalur culture-based learning can affect the achievement of students' cultural concern profile by obtaining an average score of high categories in the modeling class and very high in the implementation class. Although the average results are in two different categories, when tested through non-Parametric statistics the two results do not have a significant difference
Isolation of Cellulolytic Bacteria from Kalkun (Meleagris gallopavo) Gastro-Intestinal Tract as a Candidate Probiotics for Poultry
Authors: Suryadi Muh. Aidil Fitriyan Fadjar , Mursyid Muhammad Hipzul , Anwar Khairil , Ali Muhamad , Kisworo Djoko
Published: June 2023

This study has been conducted to isolate and identify cellulolytic bacteria from the digestive tract of turkeys (Meleagris gallopavo) as probiotic candidates for poultry. This study has obtained 4 bacteria that have the potential as probiotic candidates through the morphological identification stage, the ability to produce cellulase enzymes and resistance to acidic pH conditions. The test found that RDL code bacteria bacteria have the highest ability to produce enzyme cellulase characterized by the formation of a clearing zone with a diameter of 11 mm, the second highest PVB2 code bacteria with a clearing zone diameter of 7 mm, DB1 4 mm, and RSL 2 mm and the results of bacterial viability tests isolated at low pH (2.0) showed the highest viability after incubating for 4 hours. RDL viability is 65%, RSL 48%, DB1 50%, and PVb2 29%. So based on the tests that have been carried out, it is estimated that the 4 bacteria are candidates for Lactobacillus sp. worthy to be used as a probiotic for poultry
Construction of CNN Algorithm Model for Predicting the Health Status of Bombyx Moth Larvae Using the Gram Staining Pattern of Intestinal Microbes
Authors:   Korean Science Education Society for the Gifted, Hong Joongi , Yoon Dockhan , Oh Seoyeon , Kim Minsuh , Lee Jiyeon
Published: June 2023

The present article confirms the crucial role of the microbial environment in the large intestine as a measure of individual health, as demonstrated through silkworm larvae feces. To further explore this, an artificial intelligence-based Convolutional Neural Network (CNN) model was constructed using Gram staining pattern data of intestinal microbes, and its usability was confirmed. In order to investigate the effect of intestinal inflammation on individual health, silkworm moth larvae were fed Dextran Sulfate Sodium (DSS) along with mulberry leaves, and the concentration of DSS was varied. The experimental group exhibited a low distribution ratio of Proteobacteria at the Phylum level, while the control group had a high distribution ratio. The opposite trend was observed in Firmicutes, which was confirmed by changes in the Gram staining pattern at the sub-classification stage. The experimental group had a lower species diversity index compared to the control group, suggesting a significant effect of the DSS solution treatment on individual health. As a result, cocoon formation occurred more rapidly in the experimental group, and the rate of molting increased with weight gain. The CNN algorithm model was developed using big data on Gram staining patterns of intestinal microbes from both the experimental and control groups. Verification using the validation group demonstrated high accuracy. These findings suggest that the health status of silkworm larvae can be predicted through intestinal microbes using the CNN algorithm model, provided that pre-processing procedures such as Gram staining are further elaborated in future studies.
Watermelon Sorting Using Sound Waves: Based on Machine Learning
Authors:   Korean Science Education Society for the Gifted, Min Seunghee , Lim Gaeun , Shin Yeonwoo , Lee Taeyoon , Lee Seunghwan , Cho Daeki
Published: June 2023

The purpose of this study is to predict the ripeness of watermelon by the hitting sound. It was found that the reverberation time, the thickness of the skin, and the volume of the pulp were significantly correlated with ripeness. The hitting of watermelon can be explained as a damped oscillation, and this was verified through experiments and simulations, and correlation analysis between reverberation time and ripeness. As a result, the reverberation time was selected as an important variable. CNN was used to develop a model that predicts ripeness through the hitting sound of watermelon, which showed 99% accuracy. 4-layer perceptron model using the reverberation time which was selected as an important variable for predicting ripeness was developed. This showed 95.7% accuracy, in conclusion proposing an objective and non-destructive method to determine watermelon ripeness.
Analysis of Competency-Based Elementary Mathematics Gifted Education Programs and Textbook of Elementary School from the Perspective of Teaching a Mathematics Expression
Authors:   Korean Science Education Society for the Gifted, Ko Junseok
Published: June 2023

In this study, ‘Mathematical expression connection’ and ‘Mathematical expression transformation’ patterns were analyzed to see if activities related to expressions appearing in competency-based mathematics education programs for gifted students and elementary mathematics textbooks were appropriately constructed from the standpoint of establishing internal connectivity between various mathematical objects. I got the same conclusion. First, it was found that there needed to be more opportunities to observe the presented equations in terms of the expression connection aspect, express them as phenomena, and interpret new expressions, mathematical relationships, and thought processes. Second, from the viewpoint of the expression transformation aspect, the purpose of transforming the expression was mostly the process of deriving the value of the expression. Therefore, it is necessary to supplement the activities of transforming expressions in various directions.
Presence of concurrent derangements of liver function tests in type 2 diabetes: A retrospective observational study.
Authors: Ayesha Siddiqa  , Sara Khan  , Maryam Rafiq  , Nudrat Fayyaz  , Farah Hanif  , Muhammad Fiaz
Published: June 2023

Objective: To know the frequency of deranged liver functions in patients with diabetes mellites and to ascertain the association between two conditions. Study Design: Retrospective Cross-sectional study. Setting: Department of Pathology Shaheed Zulfiqar Ali Bhutto Hospital. Period: 1st January, 2020 to 1st January, 2021. Material & Methods: All patients with diabetes and deranged liver functions were included in the study. Ethical approval was taken from the hospital ethical committee. Data was entered into the predefined proforma. Data was collected from hospital laboratory system. Data analyzed by using SPSS and p value of ≤ 0.05 was taken as significant. Results: In this study 102 people of both genders were included, out of these 62 were diabetic patients and 40 were age matched controls. Deranged liver function test was present between 39.20% and among these raised ALP was noted in 19.60%, ALT in 14.70% and total bilirubin in 4.90%. Liver function tests were compared between gender, and it was found that total bilirubin was significantly different between two groups. Conclusion: It can be concluded from the study that diabetes is associated with liver function derangement. ALT is significantly high in diabetic patients compared to controls.
Tindak Tutur Direktif dalam Interaksi Jual Beli di Toko Helm Riza
Authors: Priwardani Nuriza , Assidik Gallant Karunia
Published: June 2023

Penelitian ini bertujuan untuk medeskripsikan jenis tindak tutur direktif yang terdapat dalam interaksi jual beli di toko helm Riza, kemudian mendeskripsikan fungsi tindak tutur direktif yang terdapat dalam interaksi jual beli di toko helm Riza. Jenis penelitian ini deskriptif-kualitatif dengan metode analisis isi (content analysis) untuk mengkaji tindak tutur direktif dalam interaksi jual beli. Data berupa direct voice action dalam interaksi jual beli di toko helm Riza. Sumber data berupa informasi tuturan pembicaraan jual beli yang dikumpulkan dan pilih. Teknik analisis data yaitu mengumpulkan data rekaman, mengidentifikasi, menganalisis. Hasil penelitian ditemukan ada tiga jenis tindak tutur direktif pada interaksi jual beli di toko helm Riza. Pertama, tindak pertanyaan (2 data), meminta (5 data), dan perintah (1 data). Kedua, ditemukan 2 fungsi tindak tutur direktif yaitu fungsi memohon dan menekan.Kata Kunci: Tindak Tutur, Direktif, Jual beli, Interaksi
Moisture adsorption isotherms properties of dried overripe barlin fruit (Musa acuminata AA.) powder
Authors: Mohamad Efendi  , Yusuf Hendrawan  , La Choviya Hawa  , Bambang Dwi Argo  , Sumardi Hadi Sumarlan  , Bambang Susilo
Published: June 2023

Moisture sorption of dried overripe barlin banana powder using the static gravimetric method. The materials were conditioned at 5, 10, and 25 oC with a water activity range of 0.16 to 0.86. Five mathematical models to describe the suitability of the phenomenon of adsorption experimental data using non-linear regression. The thermodynamic properties such as isosteric heat and Gibbs free energy are evaluated in this paper. The experimental results indicated that the equilibrium moisture content of dried overripe barlin banana powder increased with increasing water activity and decreasing temperature. The results of the model are based on the goodness of fit, and the Peleg model is the most suitable for describing the adsorption phenomenon with the type II sigmoidal shape. Monolayer moisture content and adsorption surface area using the GAB model are in the range of 6.18-7.81%d.b and 219.09-246.39 m2/g d.b, respectively, which increases with increasing temperature. Moreover, isosteric heat decreases with an increase in equilibrium moisture content and is opposite to the value of Gibbs free energy. In addition, the hygroscopicity of the dried overripe barlin banana powder increased with temperature and water activity.
Entgrenzte Verstrickung
Authors: Würker Achim
Published: June 2023

Der Beitrag beleuchtet das Problem, dass Konflikte in pädagogischen Interaktionszusammenhängen dazu tendieren auszuufern. Ihre Begrenzung setzt die Fähigkeit voraus, den bereits von Bernfeld betonten Zusammenhang von äußeren und inneren Szenen zu lockern beziehungsweise zu reflektieren. Als eine Möglichkeit, hierzu beizutragen, wird die Interpretation von Literatur vorgeschlagen, durch die bei entsprechender methodischer Anlage als ein »Probehandeln« Selbstreflexionsprozesse, einer Supervision nicht unähnlich, wirksam werden können.
Wie auf Knopfdruck
Authors: Seidler Christoph
Published: June 2023

Friedenszeiten haben sich in Kriegszeiten gewendet. Das hat die gesamte Kultur desintegrativ beeinflusst. Das gegenwärtige Kriegsgeschehen und seine Wirkungen auf die Gesellschaft werden mithilfe von drei Konzepten aus psychoanalytischer und gruppenanalytischer Sicht untersucht. Eine Absicht besteht darin, Halt in Besinnung und Distanz zu finden und dem Sog des Krieges zu widerstehen. Ein zentrales Konzept ist dabei die Soldatenmatrix, die auch die unbewussten und immer reziproken Prozesse in der Gesellschaft, in der jetzt Krieg herrscht, zu verstehen sucht. Ponsonbys Gesetze der Kriegspropaganda sind schon seit hundert Jahren bekannt, werden aber ungern zur Kenntnis genommen. Manche Muster von Beziehungsstörungen in Gruppen sind anwendbar auf gesellschaftliche Prozesse. Sie können behilflich sein, diese Störungen aufzudecken, einzuordnen, den Spaltungen Schärfe nehmen und einen Dialog zu ermöglichen. Eine andere Absicht besteht darin, zu überprüfen, ob sich diese Konzepte in der Lebenspraxis bewähren und hilfreich sind.
The Effects of the Nutrition Lottery Draw Game to Increase Nutrition Knowledge
Authors: Jaladri Iman , Ginting Martinus , Sudarto Sudarto
Published: June 2023

A good generation must be created through effort and real work. One generation is a group of schoolchildren who are the nation's investment. A complete generation must be supported by good nutrition. In order to fulfill good food ingredients, of course, it requires proper nutritional knowledge. This study aims to determine the effect of the nutrition lottery draw game media on increasing nutritional knowledge in elementary school children. The research design used a quasi-experimental design (Non-Randomized group pre-test post-test) with research subjects of as many as 48 children divided into 2 (two) treatment groups (each group consisting of 24 people). The subjects of the study employed the students in Elementary School 17 and 20 Siantan, Jungkat District, Mempawah Regency in March 2021. Data analysis with Wilcoxon test and Man-Whithney. Furthermore, the intervention was carried out for one month effectively and divided into 2 (two) groups, namely, one group was provided games treatment and one group had no treatment. There were differences in knowledge scores before and after the intervention in the control and treatment groups. There was no difference in the increase of knowledge scores in the treatment and control groups.

 

Keywords: Games, Nutritional Knowledge, Schoolchildren
FEATURES OF THE DEVELOPMENT OF SLIPPING ALONG THE BOUNDARIES HETEROPHASE INCLUSION “HIGH-MELTING PHASE SURROUNDED BY A LOW-MELTING SHELL” − STEEL MATRIX
Authors: GUBENKO S.I. , PARUSOV E.V. , CHUIKO І.М.
Published: June 2023

Purpose. To study features of slippage at the interphase boundaries, heterophase inclusion “refractory phase surrounded by a low-melting shell” − steel matrix in the temperature range of hot deformation. Methods. Samples of steels were subjected to stretching at temperatures of 20...1 200 °C in a vacuum on the IMASh-5S device with special grippers, the speed of which was 20 mm/min. Research methods were used: petrography, micro-X-ray spectral analysis (“Cameca MS-46, Nanolab-7”, optical microscopy (Neophot-21). Results. It was found that the diversity of phases composing the heterophase inclusions of the “high-melting phase surrounded by a low-melting shell” type leads to their different behavior under plastic deformation. It was shown that during the high-temperature deformation the inclusion − matrix interphase boundaries, which are the boundaries between the inclusion-shell phase and the steel matrix, exhibit plasticity as a result of slipping. It was found that depending on the plasticity level of the phases composing the inclusion, the slipping occurs with different intensity. The features of the slipping process for heterophase inclusions of the “high-melting phase surrounded by a light-melting shell” type were analyzedScientific novelty. It is discussed the slipping mechanism for inclusions of the “high-melting phase surrounded by a low-melting shell” type containing phases with different plasticity levels, which is associated with the movement of interface dislocations at the inclusion − matrix boundaries (intrinsic slipping) or inserted dislocations as well as with contact friction and internal friction occurring at the boundaries due to the dislocation movement. It is shown that the activation of the slipping can occur due to the rearrangements of defects located at the interphase boundaries of the inclusion − matrix of steel. It was established that the difference in the nature of the phases-shells, as well as the influence of the second phase of inclusions “high-melting phase surrounded by a low-melting shell” contribute to difference in plasticity of inclusion-matrix boundaries of steel under high-temperature deformation. Practical value. The use of the obtained results will make it possible to develop technologies for producing steels with regulated types of heterophase non-metallic inclusions, which will significantly increase their technological and operational characteristics, as well as prevent the formation of various defects during the processing of steels by pressure and the operation of products.
PREDICTION OF THE STRUCTURAL STATE OF THE WORKING LAYER OF LARGE-SIZE ROLLS DURING THERMAL HARDENING
Authors: PARUSOV E.V. , BOBYR S.V. , PRYKHODKO I.Yu. , CHUIKO I.M. , ZAKHARCHUK S.S.
Published: June 2023

Problem statement. High-carbon steels, which are additionally alloyed with chromium, molybdenum, and vanadium, are used during the production of large-sized rolling rolls for hot deformation. Rolling rolls are subjected to significant loads during operation, so they must have sufficient hardness and resistance to wear. Steels of the type 65Cr3SiMoV, 80Cr3MoV, 80Cr5MoV have recently been used for the production of hot-formed rolling rolls, but despite this, their resistance to wear in harsh operating conditions is insufficient. There is no information in the literature about the peculiarities of the austenite decay kinetics of the specified rolled steels, therefore, this direction requires appropriate comprehensive research. Purpose. Development of a methodology for predicting the structural state of the working layer of large rolling rolls in the process of thermal strengthening of high-carbon alloy steels, taking into account the determining parameters of the manufacturing technology. Results. A methodology for modeling phase-structural transformations in the process of continuous cooling of high-carbon alloy steels was developed. For steels 65Cr3SiMoV, 80Cr3MoV, 80Cr5MoV were constructed thermokinetic diagrams and on their basis, the peculiarities of the formation of the structural state of the working layer of large rolling rolls (support, working) during thermal hardening were investigated. It has been established that the method of hardening by volumetric heating of support rolls made of 65Cr3SiMoV steel ensures the formation of a bainite structure over the entire normalized depth of their working layer. For working rolls made of 80Cr3MoV and 80Cr5MoV steels, the most effective method is hardening with differentiated heating, while in the latter case continuous cooling should be carried out at a slower speed.
The relationship between the protective factors and science and mathematics achievements of the socioeconomically disadvantaged students
Authors:   Graduate School of Natural and Applied Sciences, Erzincan Binali Yıldırım University, Erzincan, Turkey, Yalçin Evren Osman , Yalçin Paşa ,   Department of Mathematics and Science Education, Faculty of Education, Erzincan Binali Yıldırım University, Erzincan, Turkey
Published: June 2023

This study aims to investigate the relationship between some protective factors and the academic achievements in science and mathematics classes of socioeconomically disadvantaged eighth-grade students. The quantitative research method and relational screening model were employed in the research. The sample of the study consisted of 250 students between the ages of 12 to 13, who were at the eighth-grade level, from a small province in Eastern Anatolia. Research data were collected from the seventh-grade science and mathematics achievement scores of the students to whom the school attachment, cognitive flexibility, and social support scales were applied. As a result of the analysis consisting of the Pearson Correlation Coefficient; there was a positive significant relationship between school attachment, social support, and cognitive flexibility protective factors and students’ science and mathematics achievement scores. It has been observed that the results of this study are compatible with the results of the studies conducted on similar subjects in the literature. Keywords: Cognitive flexibility, school attachment, science and mathematics education, social support, socioeconomic status.
A study on the cadastral investigation before the Meiji Restoration in Japan
Authors:   Korean Public Land Law Association, Choi In-Ho
Published: June 2023

The purpose of the study to understand the cadastral survey and ownership management of land prior to the Meiji period. The temporal scope of this study is limited to the Nara period from 710 to 1868. A cadastral investigation is a survey conducted mainly by municipalities to survey the land owner, parcel number, and purpose of land use and to measure the location and area of ​​the boundary for each parcel. However, there was no term for cadastral research at that time, but the same applies in terms of content. As a result of the study, manors and land subject to public authority in the late Heian period are divided into two types: manors, which are private lands controlled by aristocrats or temples, and public domains, which are controlled by public officials dispatched from the state. The manor and public land in the Kamakura period are changed by the invasion of the manor and public land by Jidu. And in the Muromachi period, the power of the nobles and monks who ruled the manor and the government officials dispatched from the state, who ruled the territories, weakened, and disputes over land became more and more complicated. In Taehap Geomji, first, the person who cultivates the farmland became the owner of the land. Second, the people had to pay taxes according to the amount of agricultural production. Third, samurai and peasants were completely separated, and farmers were only obligated to pay taxes as ownership of farmland was recognized. After such a cadastral survey of Taehap, it is suggested that the development of small agriculture and the increase in agricultural productivity in Japan served as a great foundation for a smooth transition from medieval feudal society to modern society.