bluuebunny/crossref_metadata_2025 huggingface dataset:
Комплекс находок Нового времени со стоянки Первомайский-1 (Южное Зауралье): к вопросу о типологии, хронологии и этнокультурной принадлежности памятника
Authors:   Institute of History, Language and Literature of the Ufa Federal Research Centre of the RAS, Savelev Nikita S. , Saveleva Anna G. ,   Institute of History, Language and Literature of the Ufa Federal Research Centre of the RAS, Nikolaev Sergey Yu. ,   Institute of History, Language and Literature of the Ufa Federal Research Centre of the RAS
Published: January 2021

Goals. The article publishes and analyzes archaeological materials of the modern period found at Pervomaisky-1 site discovered in foothill-steppe areas of the Southern Trans-Urals (a high plateau 14 km west of the right bank of the Ural River, Abzelilovsky District, Republic of Bashkortostan, Russia) in 2019. Materials. The collection includes three groups of pottery (coarse, gray-clay and red-clay), porcelain and earthenware dishes, various iron products (knives, harrow teeth, fragments of a cast-iron pot, horseshoes, etc., and no weapons traced), pieces of iron ore, animal bones, etc. Results. The source analysis of the finds and analogies from the rest of the Urals, Volga Region and Western Siberia made it possible to date the site to the mid — late 19th century and typologically classify it a short-term sedentary agricultural settlement. The paper establishes a relative synchronicity of all types of pottery (including impurities to clay dough), porcelain and earthenware, showing a high proportion of tableware and ‘tea’ utensils, which may be associated with the type of the site. The absence of large cast-iron cauldrons is defined as a marker of some agricultural (not nomadic) population. The involvement of historical data and cartographic materials deepened the analysis and made it possible to determine the site is a field camp of Cossacks from Magnitnaya stanitsa (Orenburg Cossack Host) that emerged after the establishment of Novolineiny District and the 200 km eastward transfer of Russia’s national frontier. This resulted in the territory turned into a deep rear area. So, the former fortress became a rich village where trade was developing and the population was rapidly increasing. Cartographic data show the object was located in the center of a narrow (5-6 km) arable land strip bounded by the main transport artery of the region — Orenburg Post Road — in the east, and by the border of Cossack and Bashkir lands in the west. The conducted comprehensive studies substantiate dating parameters of the archaeological complex which is of great importance for further development of modern history-related archeology in the entire Ural–West Siberian Region, and show the likely abundance of agricultural field camps across the territory that can be viewed as a separate type of archaeological objects.
TO THE QUESTION OF RELEVANCE OF STUDYING ORNAMENTAL ART OF PRIAMURYE IN THE SYSTEM OF ADDITIONAL EDUCATION IN ART
Authors:   D.R. Slipetskaya  Pacific State University, Slipetskaya D.R. , Martynov V.V. ,   V.V. Martynov  Pacific State University, Martynova N.V. ,   N.V. Martynova  Pacific State University
Published: January 2021

The article is devoted to the study of the problems of generating interest in the folk art of the Amur region, which allows it to be considered in conditions of additional art education at the level of familiarization with the history of origin and classification of works, teaching ornamental art, interpretation of such with a view to self-realization of students in the creative process, their self-development and cultural identification.
METHOD OF DESIGNINGTHE SPACE OF A RESIDENTIAL YARD
Authors:   A.V. Shutka  Voronezh State Technical University, Shutka A.V. , Kislyanskikh V.V. ,   V.V. Kislyanskikh  Voronezh State Technical University, Vinogradov A.V. ,   A.V. Vinogradov  Voronezh State Technical University
Published: January 2021

The article deals with the principles of designing yard spaces of residential houses. Analyses of a notion «conception» in context of project thinking in architecture and design.
PROBLEMS OF PLASTIC PARKING SOLUTIONS IN THE URBAN ENVIRONMENT
Authors:   A.G. Shipilov Far Eastern Federal University, Shipilov A.G. , Kuzmenko T.S. ,   T.S. Kuzmenko Far Eastern Federal University
Published: January 2021

This article deals with the problem of designing car parks in the modern urban environment. Special attention is paid to the search for architectural expressiveness. The article reveals the methods of achieving architectural expressiveness. The characteristic features of plastic solutions for car parks based on the world experience in the construction and construction of such buildings and structures are highlighted and described separately. The author's solution of car Parking on the selected site with the use of space-rod construction of the coating, as one of the techniques of plastic solutions, is given.
ANALYSIS OF THE PREDESIGN SITUATION ON DEVELOPMENT OF THE UNIFORM FOR PERSONNEL HOTEL COMPLEX «SMALL VENICE»
Authors:   E.V. Pshenichnikova  Amur State University, Pshenichnikova E.V. , Shaporeva M.A. ,   M.A. Shaporeva  Amur State University
Published: January 2021

In article the question of the importance when developing new models of clothes of the analysis of a predesign situation allowing to allocate the major factors having the greatest impact on the choice of the art and design solution of models in the course of design search is brought up. The list of identification signs of a national suit for carrying out comparative characteristic with the projected uniform models is submitted.
CRITERIA OF EFFICIENCY OF WORK OF PHOTO CLUB «LAGONAKI» IN THE SYSTEM OF ADDITIONAL EDUCATION OF THE REPUBLIC OF ADYGEY
Authors:   S.Sh. Evtikh Adygea State University, Evtikh S.Sh. , Sysoeva V.A. ,   V.A. Sysoeva Adygea State University
Published: January 2021

The article examines the effectiveness of the «Lagonaki» photo club in the perspective of the system of additional art education in the Republic of Adygea. Its main criteria are revealed.
Bioinformatic Approaches for Identification of Potential Repurposable Drugs in COVID-19
Authors: Mandal Manisha , Mandal Shyamapada
Published: January 2021

Introduction: Repurposing existing drugs approved for other conditions is crucial to identifying specific therapeutics against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) causing COVID-19 (coronavirus disease 2019) pandemic. Towards this attempt, it is important to understand how this virus hijacks the host system during the course of infection and determine potential virus- and host-targeted inhibitors.

Methods: This study elucidates the underlying virus-host interaction based on differentially expressed gene profiling, functional enrichment and pathway analysis, protein-protein and protein-drug interactions utilizing the information on transcriptional response to SARS-CoV-2 infection from GSE147507 dataset containing COVID-19 case relative to healthy control and infected cell culture compared to uninfected one.

Results: Low IFN signaling, chemokines level elevation, and proinflammatory cytokines release were observed markedly. We identified MYC-rapamycin and ABCG2-rapamycin interactions, and unique gene signatures in case (regulation of protein modification and MAPK signaling) as well as in cell (metabolic dysregulation and interferon signaling) different from known COVID-19 genes.

Conclusion: Among a plethora of repurposable drugs those appearing here with unique gene signatures might be helpful in COVID-19

Keywords: COVID-19, SARS-CoV-2, GSE 147507 dataset, protein-protein interaction, gene-drug interaction, repurposable drugs.
Bioadhesive polymers, permeation enhancers and types of dosage forms for buccal drug delivery
Authors: Samanthula Kumara Swamy , Satla Shobha Rani , Bairi Agaiah Goud
Published: January 2021

The buccal delivery is defined as the drug administration through the mucosal membranes lining the cheeks (buccal mucosa). The main impediment to the use of many hydrophilic macromolecular drugs as potential therapeutic agents is their inadequate and erratic oral absorption. Based on our current understanding of biochemical and physiological aspects of absorption and metabolism of many biotechnologically produced drugs, they cannot be delivered effectively through the conventional oral route. Because after oral administration many drugs are subjected to pre-systemic clearance extensive in the liver, which often leads to a lack of significant correlation between membrane permeability, absorption and bioavailability. Difficulties associated with the parenteral delivery and poor oral bioavailability provided the impetus for exploring alternative routes for the delivery of such drugs. This review covers the advantages, disadvantages of buccal delivery, drug and excipient selection especially bioadhesive polymers and permeation enhancers, and further a list of drugs developed as various dosage forms for buccal route of administration.

Keywords: Buccal delivery, bioadhesive/mucoadhesive, permeation enhancer, dosage forms.
To establish bioequivalence of 50mg Metoprolol Succinate extended release tablets in normal, healthy, adult, human subject under fasting condition
Authors: Singh Mahavir , Ranawat Lalit Singh
Published: January 2021

Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release Extended-release systems allow for the drug to be released over prolonged time periods. By extending the release profile of a drug, the frequency of dosing can be reduced. The study was an open label, balanced, randomized, three-treatment, three-period, three-sequence, single oral dose, crossover, bioequivalence study in normal healthy adult human subjects under fasting condition, with a screening period of 28 days prior to IMP administration in Period-I. In each study period, 27 blood samples, including one pre-dose blood sample, were collected from each subject except for the discontinued / withdrawn subjects to analyze the pharmacokinetic profile of the two test products (T1 and T2) as well as the reference product. The pharmacokinetic parameters were calculated from the plasma concentration vs. time profile by non-compartmental model using Phoenix® WinNonlin® Version 6.4 (Certara L.P.) for Metoprolol. Out of 18 subjects enrolled, data of 13 subjects were analyzed. Mean Cmax is 31.634 ± 22.6007 ng/mL, 31.241 ± 20.6090 ng/mL and 31.773 ± 23.1819 ng/mL, mean AUCo-t is722.992 ± 584.3793 ng hr/mL, 658.192 ± 492.3416 ng hr/mL and 706.219 ± 546.5064 ng hr/mL, mean AUC0-inf is 751.204 ± 631.9623 ng hr/mL, 676.939 ± 519.1306 ng hr/mL and729.505 ± 578.1691 ng hr/mL for test product (T1), test product (T2) and reference product (R).Test Products (T1 and T2) when compared with the Reference Product-R meets the bioequivalence criteria with respect to Cmax, AUC0-t and AUC0-∞ for Metoprolol under fasting condition as per criteria set in the protocol.
Global Epidemiology of COVID-19 and the Risk of Second Wave
Authors: Habib Arslan , Anjum Khalid Mahmood , Ashraf Zeeshan , Principe Umutumwa Eric , Hussain Zahid , Khalid Bilal , Ramzan Muhammad
Published: January 2021

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Formulation and Evaluation of Liposome by Thin Film Hydration Method
Authors: Umbarkar Mahesh , Thakare Swapnil , Surushe Tanaji , Giri Amol , Chopade Vaibhav
Published: January 2021

Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes are generally administered by intra-venous route. In this work the liposome was prepared by using thin film hydration method. The formulated liposome is evaluated or characterised by using zeta sizer, Encapsulation efficiency, Entrapment efficiency, In vitro drug release. Main things are drug which are used for formulation of liposome was Diclofenac sodium, it having anti-inflammatory and anti-pyretic effect. The Diclofenac sodium having several adverse effects, such as depression of renal function, Liver failure for repeated administration, Local mucosal irritation, gastritis. To avoid this adverse effect Diclofenac sodium are incorporate in liposomal formulation. By formulating liposomal formulation, the bioavailability of Diclofenac sodium increase. In conventional dosage form bioavailability of diclofenac sodium is 50℅. But in liposomal formulation bioavailability of this drug increase. The final result includes that diclofenac liposome formulation shows more sustained and prolong anti-inflammatory activity.

Keywords: Diclofenac sodium, Liposome, Anti-inflammatory activity.
Termite mound cover and abundance respond to herbivore-mediated biotic changes in an African savanna
Authors: Charles Grace , Riginos Corinna , Veblen Kari , Kimuyu Duncan , Young Truman
Published: January 2021

Both termites and large mammalian herbivores (LMH) are savanna ecosystem
engineers that have profound impacts on ecosystem structure and
function. Both of these savanna engineers modulate many common and
shared dietary resources such as woody and herbaceous plant biomass, yet
few studies have addressed how they impact one another. In particular,
it is unclear how herbivores may influence the abundance of long-lived
termite mounds via changes in termite dietary resources such as woody
and herbaceous biomass. While it has long been assumed that abundance
and areal cover of termite mounds in the landscape remains relatively
stable, most data are observational, and few experiments have tested how
termite mound patterns may respond to biotic factors such as changes in
large herbivore communities. Here, we use a broad tree density gradient
and two landscape-scale experimental manipulations—the first a
multi-guild large herbivore exclosure experiment and the second a tree
removal experiment– to demonstrate that patterns in termite mound
abundance and cover are unexpectedly dynamic. Termite mound abundance,
but not areal cover not significantly, is positively associated with
experimentally controlled presence of cattle, but not wild
mesoherbivores (15-1000 kg) or megaherbivores (elephants and giraffes).
Herbaceous productivity and tree density, termite dietary resources that
significantly affected by different LMH treatments, are both positive
predictors of termite mound abundance. Experimental reductions of tree
densities are associated with lower abundances of termite mounds. These
results reveal a richly interacting web of relationships among multiple
savanna ecosystem engineers and suggest that termite mound abundance and
areal cover is intimately tied to herbivore-driven resource
availability.
Left Ventricular Outflow Tract Area After Percutaneous Transseptal Transcatheter Mitral Valve Implantation; A Three-dimensional Transesophageal Echocardiography Study
Authors: hayashi atsushi , ikenaga hiroki , nagaura takafumi , Yoshida Jun , Rader Florian , makar moody , Chakravarty Tarun , Siegel Robert J. , kar saibal , Makkar Raj , Shiota Takahiro
Published: January 2021

Background: Left ventricular (LV) outflow tract (LVOT) obstruction
increases mortality in patients undergoing transcatheter mitral valve
implantation (TMVI) in degenerated bioprostheses, annuloplasty rings,
and native mitral valves. We aimed to evaluate the left ventricular
outflow tract area after TMVI using 3-diensional (3D) transesophageal
echocardiography (TEE) and to investigate the pre-procedural cardiac
geometry affects the LVOT area after TMVI. Methods: We retrospectively
reviewed echocardiography data in 43 patients who had TMVI. A change in
pressure gradient across LVOT from before to after TMVI (∆PG) and
post-procedure 3D cross sectional area (CSA) at the level of the most
distal portion of the mitral valve stent that was closest to the LV apex
were assessed as evidence of LVOT narrowing. Results: TMVI with the use
of balloon-expandable valve system was performed for 24 bioprostheses, 7
annuloplasty rings, and 12 native valves. Compared to patients without
increase in LVOT gradient (∆PG <10 mmHg; n=33), patients with
increase in LVOT gradient (∆PG ≥10 mmHg; n=10) had smaller LV
end-systolic volume (LVESV), greater LV ejection fraction (LVEF) and
smaller aorto-mitral (AM) angle. CSA at the valve stent distal edge
showed strong association with ∆PG (r=-0.68, P<0.0001). Only
small AM angle was associated with small CSA at the valve stent
ventricular edge on multivariable analysis, independent of LVESV and
LVEF. Conclusion: Pre-procedural AM angle as well as LVESV and LVEF were
associated with LVOT narrowing in patients undergoing transcatheter
mitral valve-in-valve, valve-in-ring, and valve-in-native valve
implantation. These data may be useful for preprocedural planning.
Trends in TRECs values according to age and gender in Chinese children, and their clinical application
Authors: Zhao Qin , Zhao Xiao-Dong
Published: January 2021

T cell receptor excision circles (TRECs) are small circularized DNA
elements produced during rearrangement of T cell receptor (TCR) genes.
Because TRECS are fairly stable, do not replicate during mitosis, and
are not diluted during division of naïve T cells1, they are suitable for
assessing the number of newly formed T cells 2. In this study, we
detected TRECs in 475 healthy Chinese children aged 0–18 years in
different clinical settings. We found a strong correlation between TRECs
levels and peripheral CD4 naïve T cell numbers, but not between TRECs
levels and effector or memory CD4 and CD8 T cell numbers. TRECs levels
fell significantly compared with normal controls in patients with severe
combined immunodeficiencies (SCID) (n=7), wiskott-aldrich syndrome (WAS)
(n=22), or activated PI3Kδ syndrome (APDS) (n=5). TRECs levels in those
with signal transducer and activator of transcription 1 (STAT1)
deficiency (n=8) decreased or did not change significantly, a finding
consistent with that for CD4 naïve T cells. We also measured TRECs
levels in seven PIDs after hematopoietic stem cell transplantation
(HSCT) (WAS=5; chronic granulomatous disease (CGD)=2), and found the
complications after HSCT may reduce TRECs levels by interfering with
production of naïve T cells. In conclusion, we established reference
values for TRECs, which can be used to screen for primary
immunodeficiency diseases (PIDs) during early life and track immune
reconstitution after HSCT.
B cells and T cells Abnormalities in Patients with Selective IgA Deficiency
Authors: Bagheri Yasser , Shad Tannaz Moeini , namazi shideh , Azizi Gholamreza , Hosseini Ali , saeidi mohsen , tofighi farzaneh , Salami Fereshte , Pashangzadeh salar , Delavari Samaneh , mirmanachi babak , Rezaei Nima , Abolhassani Hassan , Aghamohammadi Asghar , Yazdani Reza
Published: January 2021

Background: Selective IgA deficiency (SIgAD) is the most prevalent
primary immunodeficiency with almost unknown etiology. This study aimed
to investigate the clinical diagnostic and prognostic values of
lymphocytes subsets and function in symptomatic SIgAD patients. Methods:
A total of 30 available SIgAD patients from the Iranian registry and 30
age-sex-matched healthy controls were included in the present study. We
analyzed B and T cell peripheral subsets and T cell proliferation assay
by flow cytometry in SIgAD patients with mild and severe clinical
phenotypes. Results: Our results indicated a significant increase in
naïve and transitional B cells and a strong decrease in marginal
zone-like and switched memory B-cells in SIgAD patients. We found that
naïve and central memory CD4+ T cell subsets, as well as Th1, Th2 and
regulatory T cells have significantly decreased. On the other hand,
there was a significant reduction in central and effector memory CD8+ T
cell subsets, whereas proportions of both (CD4+ and CD8+) terminally
differentiated effector memory T cells (TEMRA) were significantly
elevated in our patients. Although some of T cell subsets in severe
SIgAD were similar, decrease in marginal-zone and switched memory B
cells and increase in CD21low B cell of severe SIgAD patients were
slightly prominent. Moreover, the proliferation activity of CD4+ T cells
was strongly impaired in SIgAD patients with a severe phenotype.
Conclusion: SIgAD patients have varied cellular and humoral
deficiencies. Therefore, T cell and B cell assessment might help in
better understanding the heterogeneous pathogenesis and prognosis
estimation of the disease. Keywords: Primary immunodeficiency, Selective
IgA deficiency, B cell subsets, T cell subsets, flow cytometry,
proliferation assay
Modeling and thermal analysis of micro beam using COMSOL multiphysics
Authors: Ulkir Osman , Ertugrul Ishak , Girit Oguz , Ersoy Sezgin
Published: January 2021

In this study, the design and analysis of the micro beam is carried out using COMSOL multiphysics. The current passing through the beam distributes the heat energy due to its resistance that pushes the entire micro beam to the desired distance through thermal expansion. This expansion varies depending on the amount of current passing through the beam and the emitted temperature. The purpose of the model created is to estimate the amount of current and temperature increase required to cause displacement in the proposed micro beam using analysis software. In addition, displacements and temperature data produced in micro beams for different metallic materials (Al, Cu, Ni, and Pt) and different input potentials (0.3 V, 0.6 V, and 0.9 V) are reported. These materials are used as functional materials in the field of micro-electro-mechanical-system because of their important physical and electrical properties. As a result of the simulation studies, increasing the voltage increased the displacement in the materials and the resulting temperature. While there is a serious difference between the displacement data of the materials, the temperatures are close to each other. When 0.9 V voltage is applied, the highest displacement values for Al, Cu, Ni, and Pt are; 7.88 ?m, 5.36 ?m, 3.62 ?m, and 2.72 ?m, respectively. As a result, it has been observed that aluminum used in micro beam design gives a significant amount of dis?placement for the proposed geometry when compared to other metallic beams.
Extreme gradient boosting regression model for soil thermal conductivity
Authors: Yurttakal Ahmet
Published: January 2021

The thermal conductivity estimation for the soil is an important step for many geothermal applications. But it is a difficult and complicated process since it involves a variety of factors that have significant effects on the thermal conductivity of soils such as soil moisture and granular structure. In this study, regression was performed with the extreme gradient boosting algorithm to develop a model for estimating thermal conductivity value. The performance of the model was measured on the unseen test data. As a result, the proposed algorithm reached 0.18 RMSE, 0.99 R2, and 3.18% MAE values which state that the algorithm is encouraging.
The relationship between perifoveal capillary ring alterations and visual acuity in diabetic retinopathy
Authors: Petrovic Nenad , Todorovic Dusan , Sreckovic Suncica , Sarenac-Vulovic Tatjana , Jovanovic Svetlana , Paunovic Svetlana , Vulovic Dejan , Randjelovic Danijela
Published: January 2021

Background/Aim. The relationship between the foveal avascular zone (FAV) and visual acuity (VA) in retinal dis-eases remains a matter of discussion. The aim of this study was to determine the impact of diabetic macular ischemia (DMI) on VA through the analysis of the perifoveal capillary network in various stages of diabetic retinopathy - DR (non-proliferative diabetic retinopathy ? NPDR and proliferative diabetic retinopathy ? PDR). Methods. Qualitative and quantitative analysis of 143 angiograms of patients with different stages of DR was performed. The degree of macular ischemia was assessed by the analysis of 2 parameters: perifoveal capillary ring, ie, the FAZ outline irregularity, and capillary loss. Finally, a comparison was made between the degree of macular ischemia with the best-corrected VA, depending on macular thickness. Results. In the eyes with mild and moderate NPDR, without significant macular thickening, no statistically significant decrease in VA caused by macular ischemia was noticed (p = 0.81). Opposite, in a subgroup with severe NPDR and PDR, without significant macular thickening, a statistically significant difference was presented among eyes with moderate and severe macular ischemia compared to eyes with lower grades of macular ischemia (p = 0.021 and p = 0.018, respectively). In the eyes with moderate NPDR and mild macular ischemia, the increase in macular thickness resulted in a statistically insignificant decrease in VA compared to eyes with a normal macular thickness (p = 0.088). However, in the eyes with severe NPDR, every pathological increase in macular thickness caused a statistically significant decrease in VA, regardless of the degree of macular ischemia (p = 0.018?0.040). A similar relationship was also found in the eyes with PDR (p = 0.017?0.042). In the eyes with a statistically significant decrease in VA, most of the examined eyes (98%) had the FAZ outline irregularity in the nasal perifoveal subfield. Conclusion. In the absence of significant macular thickening, the destruction of one-half of the perifoveal capillary network, or greater, is associated with reduced VA. The location of macular ischemic changes in the nasal parts of the perifoveal capillary ring plays a crucial role in its effects on visual function.
The effects of combined physical procedures on the functional status of patients with diabetic polyneuropathy
Authors: Grbovic Vesna , Djukic Svetlana , Stefanovic Srdjan , Zdravkovic-Petrovic Natasa , Simovic Stefan , Jurisic-Skevin Aleksandra
Published: January 2021

Background/Aim. Diabetic polyneuropathy is a common chronic complication in patients with diabetes mellitus. The aim of this study was to determine the importance of applied physical procedures on the functional status of diabetic polyneuropathy patients compared to the group of respondents treated by alpha-lipoic acid. Methods. Sixty sub-jects were divided into two groups: group A ? diabetic polyneuropathy patients treated with physical procedures, and group B ? diabetic polyneuropathy patients treated with alpha-lipoic acid. The study has lasted for three diagnostic and therapeutic cycles, each lasting for 16 days with a time between cycles of 6 weeks. Results. Manual muscle test, range of motion, Michigan Neuropathy Screening Instrument, and Berg balance scale values showed statistically significant improvement at the end of testing group A respondents, while no improvement was shown in group B respondents. Conclusion. The application of the combined physical procedures shows clear benefits for the improvement of muscle strength and mobility of the ankle joint in respondents with diabetic polyneuropathy.
Tacrolimus-induced optic neuropathy: A case report
Authors: Zoric Lepsa , Ilic Aleksandra , Colak Emina , Mirkovic Milos , Pantelic Jelica , Miric Dijana , Kisic Bojana
Published: January 2021

Intrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive
drug with growing usage. It is usually used in prevention of transplanted
organ rejection. Its use is highly valuable, but like other
immunosupressants, it has adverse effects. One of them is optic neuropathy.
Case report. A 47-year-old white male patients who had received tacrolimus
therapy for nine years, after kidney transplantation, developed a subacute,
painless vision loss on both eyes. He was thoroughly examined on different
possible optic neuropathies and other causes of vision loss. After exclusion
of other possible causes, the diagnosis of toxic optic neuropathy was
established. His therapy was converted to cyclosporine, by his nephrologist,
but his vision had improved only slightly. Conclusion. Toxic optic
neuropathies are presented in everyday ophthalmological practice, but they
are underestimated. Diagnosis can be demanding, especially when it comes to
drugs and substances whose possible toxic effect on the optic nerve is not
widely known. Unlike other adverse effects of tacrolimus therapy on nervous
system, optic neuropathy can causes great and permanent functional
impairment.
GRANNY, LOOK HERE: ENGLISH INITIATING MOVES IN BILINGUAL CHILDREN’S DIALOGICAL INTERACTION
Authors: CHIRSHEVA GALINA N. , KOROVUSHKIN PYOTR V.
Published: January 2021

The authors deal with English initiating moves in the dialogical interaction of two monoethnic bilingual children with their parents and grandparents. The objective of the paper is to describe structural and pragmatic features of initiating moves in the dialogues of the children for six years - at the age period between one and six years old. The authors argue that the quantity of English dialogical initiating moves as well as their structural and pragmatic characteristics can show the ways of childhood bilingual development and the attitude of the children to their weak language. The results of the research demonstrate that the children maintain a positive attitude to English in their interaction with adults; however, the lack of lexical and grammatical diversity of their initiating English moves is the evidence of slow development in the weak language competence and performance. Moreover, all these results clearly show that the children’s bilingualism has been gradually developing as highly unbalanced, accompanied by the traits of L2 attrition.
THE ACMEOLOGICAL APPROACH TO THE PROFESSIONAL TRAINING OF A FUTURE TEACHER
Authors: SHEVCHENKO NATALYA N. , KOLESOV VLADIMIR I. , SMOLONSKAIA ANNA N.
Published: January 2021

Thearticleexaminesthe conceptualfoundationsoftheacmeologicalapproachasamethodologicalbasisfor modelingand implementing professional training of teachers in the educational process of higher education. In the context of the problem concerning improvement in the quality of education, the acmeological model of teacher training is considered; the factors and pedagogical conditions for the effectiveness of this process are highlighted. The article reveals the essence of the teacher's acmeological position in the systemic integration of his professional, personal, spiritual and moral formation; highlights the main indicators of the specialist’s acmeological position as an integral component of his professional competence; presents the results of the study to identify students' values within the teaching profession, priority motives in their professional development, motivation to carry out teaching activities in the structure of the professional acmeological position.
DESIGNING A SOLID-STATE MODEL OF A FABRIC REINFORCEMENT STRUCTURE OF A POLYMERIC COMPOSITE MATERIAL USING CONTROL VARIABLES
Authors: SUVOROV IVAN A. , ERSHOV SERGEY V. , KUZNETSOV VICTOR B. , KALININ EVGENY N.
Published: January 2021

The authors built a 3D model of a woven reinforcing structure of a polymer composite material using the developed software system for calculating global variables. In the developed 3D model, the control parameters are expressed using global variables, thus, the resulting model can be completely changed by varying the values of one or more control variables.
LEXICOGRAPHY IN THE SITUATION OF NEOLOGY EXTREME (BASED ON THE NEW CORONAVIRUS LEXICON)
Authors: BUTSEVA TAISIYA N. , ZELENIN ALEKSANDR V.
Published: January 2021

The research questions in this issue include the following: the first is the problem of usual meaning of neologisms. During the coronavirus pandemic there has been a flurry of new words and phrases in many languages. Such a linguistic phenomenon can be called an extreme peak in the appearance of new words and meanings. The second is the problem of assessment, the need for lexicographying such words in the explanatory dictionary, in particular, in the multivolume Dictionary of the Russian Language of the 21st century (ed. by G. N. Sklyarevskaya). General characteristics of the covid dictionary (more than 600 units), formed at the moment in Russian, are described in the article. The theoretical basis of the category of lexical neologisms is the N.Z. Kotelova’s theory, who founded an academic neographic school. She developed the principles of selecting neologisms in explanatory dictionaries and formulated specifics of those words. The article attempts to analyze covid lexemes and proposes a preliminary toolkit for selecting lexemes that can be considered as potentially usual. Almost 140 covid nominations, which make up about 23 % of the collected corpus of COVID vocabulary, have high potentiality for new words'usualisation. Research methods in this issue are: systemic, classification, statistical, deductive, inductive.
Green-Blue Spaces and Mental Health: A Longitudinal Data Linkage Study
Authors: Thompson Daniel A , Nieuwenhuijsen Mark , White James , Lovell Rebecca , White Mathew , Lyons Ronan A , Stratton Gareth , Akbari Ashley , Geary Rebecca , Wheeler Ben , Watkins Alan , Fry Richard , Rowney Francis , Mizen Amy , Rodgers Sarah E
Published: January 2021

IntroductionA growing evidence base indicates health benefits are associated with access to green-blue spaces (GBS), such as beaches and parks. However, few studies have examined associations with changes in access to GBS over time.

Objectives and ApproachWe have linked cross-sector data collected within Wales, United Kingdom, quarterly from 2008 to 2019, to examine the impact of GBS access on individual-level well-being and common mental health disorders (CMD). We created a longitudinal dataset of GBS access metrics, derived from satellite and administrative data sources, for 1.4 million homes in Wales. These household-level metrics were linked to individuals using the Welsh Demographic Service Dataset within the Secure Anonymised Information Linkage (SAIL) Databank. Linkage to Welsh Longitudinal General Practice data within SAIL enabled us to identify individual-level CMD over time. We also linked individual-level self-reported GBS use and well-being data from the National Survey for Wales (NSW) to routine data for cross-sectional survey participants.

ResultsWe created a longitudinal cohort panel capturing all 2.84 million adults aged 16+ living in Wales between 2008 and 2019 and with a general practitioner (GP) registration. Individual-level health data and household-level environmental metrics were linked for each quarter an individual is in the study. Household addresses were linked to 97% of the cohort, creating 110+ million rows of anonymously linked cross-sector data. The cohort provides an average follow-up period of 8 years, during which 565,168 (20%) adults received at least one CMD diagnosis or symptom.

Conclusion / ImplicationsThis example of multi-sectoral data linkage across multiple environmental and administrative data sources has created a rich data source, which we will use toquantify the impact of changes in GBS access on individual–level CMD and well-being. This evidence will inform policy in the areas of health, planning and the environment.
Imigrantes Hispano-Americanos no Brasil: Língua, Cultura e Identidades
Authors: Sá Rubens Lacerda de
Published: January 2021

O trinômio que alicerça o subtítulo deste ensaio está circunscrito e intrinsecamente relacionado com meu interesse de pesquisa: imigrantes hispano-americanos no Brasil e mais especificamente os imigrantes bolivianos que chegam a São Paulo. Esses passam por um processo de (des)fragmentação de sua identidade e de (in)visibilidade social levada a termo especialmente através da língua(gem) (SÁ, 2015). Logo, ressalto que este ensaio é fruto de reflexões oriundas de uma pesquisa realizada junto ao Programa de Pós-Graduação em Linguística da Universidade de Brasília. Posto isto, destaco que meu almejo é fazer uma sucinta incursão nessa temática ao longo deste texto tendo a questão do acolhimento por um viés interculturalista como pano de fundo.
Planejamento socialmente construído no limiar do pós-pandemia
Authors:   Programa de Pós-Graduação em Planejamento Urbano e Regional Universidade do Vale do Paraíba., Gomes Cilene
Published: January 2021

Objetivo: O ensaio explora a abordagem conceitual do planejamento socialmente construído centrado na dimensão do território usado. No limiar do pós-pandemia, a reflexão se justifica pela necessidade de agregação do valor de conscientização política à ação social e de salvaguarda e aprimoramento da democracia. Conjectura-se na constituição e conjugação de esferas públicas para o debate social e a ação política, e na construção de projetos alinhados por aspirações e interesses comuns. Chega-se ao reconhecimento de matrizes interpretativas convergentes acerca da sócio diversidade e do princípio de construção do comum, considerando outras racionalidades e experiências inovadoras nascentes nas fissuras da arena hegemônica. Palavras-chaves: Território usado. Ação política. Democracia. Esferas públicas. Princípio do comum.
Catadores na Pandemia: Velhos e Novos Valores
Authors:   Universidade Tecnológica Federal do Paraná (UTFPR)., Bezerra Stella Maris da Cruz , dos Santos Yara Muller , Gonçalves Adrineia Tecchio
Published: January 2021

Objetivo: Este ensaio objetiva analisar a atuação dos catadores de materiais recicláveis nas cidades, durante e após a pandemia da COVID-19. O fio condutor desta reflexão contempla três aspectos principais: a conexão entre o histórico da exploração de trabalhadores em extração de recursos naturais na América Latina, com a atual exploração dos catadores de materiais recicláveis no Brasil; o posicionamento dos catadores durante a pandemia; e as antigas e novas demandas de planejamento urbano para mitigar desigualdades sociais e promover cidadania, independentemente da ocupação profissional. As análises abrangem provocações quanto ao olhar sobre os catadores e ações necessárias para inclusão urbana. Palavras-chaves: Catadores. Pandemia. Empoderamento. Visibilidade. Planejamento urbano.
PENAMBAHAN BEBERAPA JENIS BAHAN NUTRISI PADA MEDIA PERBANYAKAN UNTUK MENINGKATKAN VIRULENSI BEAUVERIA BASSIANA TERHADAP HAMA WALANG SANGIT
Authors: Nuryanti Ni Siluh Putu , Wibowo Lestari , Azis Abdul
Published: January 2021

A research was conducted to increase the virulence of Beauvaria bassiana to the rice bug, L.  acuta, by adding four different substances (materials) to the rice media to grow the fungus. The research was conducted from April to August 2011 at Polinela Laboratory, Bandar Lampung.  To do this a set of experimental unit consisting of five treatments and five replications were arranged in completely randomized design. The  four treatments were media made up of rice (rice based media) each given or added with four different materials such as rice skin powder, corn sugar, grasshopper powder and chitosan powder. The result showed that B. bassiana grown on rice media added with grasshopper powder or rice skin powder were able of causing mortality to the L. acuta as high as 78% and 71%, respectively, meaning that both mortalities were much higher than that of other replication. The virulence values of Beauveria bassiana  grown on those both powder were also higher than that of three others.
KOMPATIBILITAS CENDAWAN ENTOMOPATOGEN BEAUVERIA BASSIANA (BALS) VUILL (DEUTEROMYCOTINA: HYPHOMYCETES) DENGAN MINYAK SERAI WANGI
Authors: Trizelia Trizelia , Rusli Rusdi
Published: January 2021

Entomopathogenic fungi  such as Beauveria bassiana are important natural control agents of many insects and can be potentially used as a bioinsecticide against several pests. Other potential source of bioinsecticide is certain plants such as fragrant lemongrass oil.  The in vitro compatibility of the entomopathogenic fungus B. bassiana  and  fragrant lemongrass oil was evaluated.  Fragrant lemongrass oil was tested in three different concentrations (0.1, 0.3 and 0.5%). Fragrant lemongrass  oil  was diluted in the steril SDAY medium at the different concentrations. Effects of these concentrations on conidia germination, colony growth and sporulation were compared.  Fragrant lemongrass  oil  affected conidial germination, colony growth and sporulation of B. bassiana. Fragrant lemongrass  oil  was not compatible with the entomopathogenic fungus B.  bassiana.
PATOGENISITAS ISOLAT BEAUVERIA BASSIANA DAN Metarhizium anisopliae ASAL TANAH LEBAK DAN PASANG SURUT SUMATERA SELATAN UNTUK AGENS HAYATI Scirpophaga incertulas
Authors: Thalib Rosdah , Fernando Redi , Khodijah Khodijah , Meidalima Dewi , Herlinda Siti
Published: January 2021

Pathogeicity of Beauveria bassiana and  Metarhizium anisopliae Isolates from Fresh Swamp and  Tidal Lowland, South Sumatra for Scirpophaga incertulas Biological Agents.  The objectives of the research weret o explore and to determine the pathogenicity of entomopathogenic  fungi againts the larvae of Scirpophaga incertulas, and to measure conidial viability and density of the fungi.  The method for fungi exploration used larvae of Tenebrio molitor baiting submerged in the soil.  The soil was taken from fresh swampand tidal lowland rice in South  Sumatra.  From the exploration study, we found two species of entomopathogenic fungi: Beauveria bassiana and Metarhizium anisopliae. Mortality of S. incertulas larvae that had been treated topically with fungal conidia (1x106 conidia ml-1) varied among the isolates. The highest mortality (98.33%) caused by BPlus isolate of B. Bassiana and the lowest by MtmIn  isolate of M. anisopliae (57.50%) and BTmTr  isolate of B. bassiana (57.50%).  The fungal colonies grew fast from the second day up to the fourth day after incubation but the growth became slow after the fifth day.  The highest conidial density was resulted by   BPcMs of B. bassiana isolate (63.33x106 conidia ml-1) but  this density was not significantly different from that of the BPlus  of B. bassiana isolate (63.11x106 conidia ml-1).  The lowest conidial density found in BTmTr of B. bassiana isolate (20.97x106 conidia ml-1) .   The isolate B. bassiana was more effective than M. anisopliae againt the larvae of S.incertulas.
TOLERANSI TANAMAN PENEDUH POLYALTHIA LONGIFOLIA DAN PTEROCARPUS INDICUS TERHADAP Ganoderma sp.
Authors: Widyastuti Siti Muslimah , Harjono Harjono , Riastiwi I
Published: January 2021

Susceptibility of Urban Trees Polyalthia longifolia and Pterocarpus indicus to Infection of  the red root rot fungus Ganoderma sp. Urban trees on the Gadjah Mada University (UGM) area play an important role in increasing environmental qualities as well as in supporting the teaching and learning processes. However, red root rot disease caused by Basidiomycete Ganoderma sp. has severely infected some existing urban trees. This experiment was aimed to determine the susceptibility of Polyalthia longifolia (glodokan) and Pterocarpus indicus (angsana) to the infection of Ganoderma sp. Identification of infected trees was performed in UGM area. Further steps were carried out to achieve those objectives : (1) isolation of Ganoderma spp. and testing of Koch’s postulate and (2) examination of the susceptibility of  P. longifolia and P. indicus to infection of Ganoderma sp. The susceptibility test of P. longifolia and P. indicus to Ganoderma sp. indicated that P. longifolia was more resistant to fungal pathogen infection than that of P. indicus. Based on this experiment, it can be concluded that P. longifolia is a species that is more suitable than P. indicus.  P. longifolia should be planted on the areas that have been infested with inocula of Ganoderma sp..
PENINGKATAN KETAHANAN TANAMAN PISANG BARANGAN TERHADAP BLOOD DISEASE BACTERIUM (BDB) DENGAN APLIKASI FUNGI MIKORIZA ARBUSKULAR INDIGENUS
Authors: Suswati Suswati , Najril Nasir , Azwana Azwana
Published: January 2021

Increase resistence of barangan banana blood disease bacterium using Indigenus arbuscular mycorhizae fungi.  Blood disease caused by Blood disease bacterium (BDB) is the major cause of production loss of banana in Indonesia. There is currently a lack of information about the application of  indigenous Arbuscular mycorrhizal fungi (AMF) to increase the Barangan banana resistance to BDB. A greenhouse experiment was conducted to evaluate the increase resistance Barangan banana to  3 (three) types of AMF (Glomus type-1; Acaulospora type-4 and Glomus fasciculatum) and control (without AMF) with 3 replicates. Barangan banana plantlet were inoculated with 50 g fresh AMF inoculants and at 14 days after acclimating have transplanted to soil contaminated BDB. Observation on the Barangan banana seedlings was done after 5-60 days after application  included percentage disease, severity disease, incubation periode, BDB population in rhizosfer and AMF percentage root colonization. The result indicated that AMF increased Barangan banana resistance to BDB. Glomus type-1 and G. fasciculatum increased banana resistance by 100% while Acaulospora type-4 takes 66.67% and control none. The disease severity with Acaulospora tipe-4 is 6% lower than controls (32.6%). The highest suppression level was  found in 2 isolates of Glomus application was 100% and was followed Acaulospora type-4 is 81.59%. The low intensity of on FMA indigenous treatment applications related to the incubation period and BDB density in rhizosphere of plant roots. The incubation period in mychorized plants  has longer 30 dap than controls (10 dap).
PARAMETER NERACA HAYATI DAN PERTUMBUHAN POPULASI KUTU PUTIH Phenacoccus manihoti Matile-Ferrero (HEMIPTERA: PSEUDOCOCCIDAE) PADA DUA VARIETAS UBI KAYU
Authors: Wardani Nila , Rauf Aunu , Winasa Wayan , Santoso Sugeng
Published: January 2021

ABSTRACTThe life history and population growth parameters of mealybug Phenacoccus manihoti Matile-Ferrero (Hemiptera: Pseudococcidae) on two cassava varieties. The development, reproduction, and population growth parameters of the cassava mealybug, Phenacoccus manihoti Matile-Ferrero (Hemiptera: Pseudococcidae) on two cassava varieties were studied in laboratory. The varieties tested were UJ-5 with high cyanide content (>100 mg per kg) dan Adira-1 with low cyanide content (27.5 mg per kg).  Our research revealed that P. manihoti performances were highly affected by cassava varieties.  Incubation period of eggs of P. manihoti were 7.93 ±  0.09 and 8.33 ± 0.11 days, nymphal development periode 12.32±0.13 and 15.67 ± 0.13 days, respectively on UJ-5 and Adira-1. Fecundity averaged 386.37 ± 5.83 on UJ-5 and 318.67±2.81 eggs on Adira-1. Intrinsic rate of increase (rm) were  0.258 ± 0.001 on UJ-5 and  0.220 ± 0.001 on Adira-1. Mean generation time (T) on UJ-5 and Adira-1 were 22.795 ± 0.050 and 25.532 ± 0.047 days, repectively. Our findings showed that variety UJ-5 was more suitable for development and population growth of the cassava mealybug.
POLA AKTIVITAS HARIAN DAN DINAMIKA POPULASI LALAT BUAH BACTROCERA DORSALIS COMPLEX PADA PERTANAMAN JERUK DI DATARAN TINGGI KABUPATEN KARO PROVINSI SUMATERA UTARA
Authors: Manurung Binari , Prastowo Puji , Tarigan Emmi Ebrina
Published: January 2021

The fruit fly Bactrocera dorsalis complex is important pest on citrus plantation at highland Karo district North Sumatera Province. The studies with the aim to find out its daily activity pattern and population dynamic on citrus plantation have been done. Fruit flies were collected by water bottle trap with methyl eugenol attractant. Sampling for daily activity pattern was done per two hours for two months (April to May 2011) from 06.00 a.m until 18.00 p.m. Meanwhile, population dynamic study was conducted on two citrus plantations per four days for nine months (March to November 2011) in the first and third week of each month. The research result showed that B.dorsalis complex was more active during morning at 10.00 to 12.00 a.m. The peak abundance of fruit fly occurred at the end of June until beginning of July. The peak population coincided with the ripening period of fruits, low number of rainy (d) and rainfall (mm) in June and July periods. There was a significant correlation between number of rainy day and rainfall with fruit flies caught per month (R = 0.79; Y = 289.34+14.23X1-15.93X2; R2 = 0.62; P < 0.05). The pattern of fruit fly fluctuation in two citrus plantations was similar (rs = 0.47; P < 0.05).