bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and Evaluation of Antigens for Use in the Serologic Diagnosis of Human Hydatid Disease
Authors: Norman Lois , Kagan Irving G.
Published: January 2023

Reactions of three lots of SHF antigen with several homologous antisera in Ouchterlony and immunoelectrophoretic slides were studied. Standard patterns of lines were delineated which could be used reliably in the identification of identical antigens in other source materials. Particular attention was paid to characterization of the parasite components (P1, P2, P3), most often present in antigens which were potent in the HA test. Chromatographic methods used to separate serum components were applied to SHF antigen. Separation of parasite and host antigens was not accomplished with either ion-exchange columns or various Sephadex columns. Considerable amounts of host material were removed by serial cycling of the antigen through a G-50 Sephadex column followed by cycles through long G-200 Sephadex columns. A stable, serologically reactive antigen resulted that still contained at least six components.
Effect of Interferon Treatment on Interferon Production
Authors: Friedman Robert M.
Published: January 2023

Treatment of cells with high concentrations of interferon inhibited their subsequent ability to produce interferon, while treatment with low concentrations facilitated interferon production and caused very early production to take place. This priming effect required cellular metabolic activity; protein synthesis appeared to be necessary. The latter was indicated by the inhibition of priming in cells treated with p-fluorophenylalanine.
Mitogenic Activity of Bacterial Fractions in Lymphocyte Cultures
Authors: Heilman Dorothy H. , McFarland William
Published: January 2023

Purified fractions of tuberculin prepared by Seibert were tested for the ability to cause blast-cell transformation in cultures of peripheral blood leukocytes from normal donors and from patients with tuberculosis, sarcoidosis and myocarditis. The fractions tested included a purified protein derivative of tuberculin (PPD-S), polysaccharide I which contained 12.8% of protein, and polysaccharide II which contained a trace of protein. PPD-S caused transformation of lymphocytes from healthy Mantoux-positive individuals. Polysaccharide I caused a low but significant rate of lymphocyte transformation in approximately one third of tests employing leukocytes from Mantoux-positive donors. Polysaccharide II did not stimulate blast-cell transformation in any instance. The mitogenic activity of the purified fractions was directly proportional to the amount of biologically active protein present. The partial or complete failure of purified polysaccharides I and II respectively to stimulate blast transformation in cultured leukocytes from tuberculin-sensitive individuals was consistent with the apparent inability of some polysaccharide antigens to evoke a characteristic anamnestic response.
Relationship of Interferon-Like Inhibitor Production to Rous Sarcoma Virus Growth and Tumor Formation in Chicks
Authors: Force Elizabeth E. , Stewart Richard C.
Published: January 2023

An interferon-like inhibitor was found in Rous sarcoma virus (RSV)-infected wing web tissues of the chick prior to the appearance of infectious RSV, tumor formation, viremia and circulating antibody. This inhibitor possessed several of the properties generally ascribed to interferon.
Antibody Heterogeneity in Experimental Listeriosis
Authors: Aalund Ole , Osebold John W. , Murphy Frederick A. , Di Capua Richard A.
Published: January 2023

In uninoculated sheep and cattle, IgM antibodies to Listeria monocytogenes types 1, 2 and 4b were uniformly demonstrable. The 7S antibodies were divided into subclasses designated “slow IgG” and “fast IgG.” It was noteworthy that only one sheep in a group of 12 ruminants had 7S antibodies (slow IgG) to Listeria serotype 4b prior to immunization. Thus the basis for antibody activity in the serum of apparently normal animals is largely a function of the IgM class of immunoglobulins. All immunized animals synthesized both subclasses of 7S antibodies.

Results were less distinctive on studies with Listeria types 1 and 2, Staphylococcus aureus and Streptococcus faecalis. Among four sheep studied in detail all contained IgM agglutinins prior to immunization, in addition to variable distribution of 7S antibody populations reacting with the four microorganisms. Whole serum titers to Listeria types 1 and 2 were not markedly increased by immunization of the animals with the Streptococcus or Staphylococcus. However, titers did increase following the inoculation of live Listeria cells into the same animals.

The detection of IgG agglutinins to Listeria type 4b in serum after reduction of IgM globulins with 2-mercaptoethanol would appear to have diagnostic significance.
Pathogenesis of Experimental Cholera: Identification of Choleragen (Procholeragen A) by Disc Immunoelectro-Phoresis and Its Differentiation from Cholera Mucinase
Authors: Finkelstein Richard A. , Sobocinski Philip Z. , Atthasampunna Pongsom , Charunmethee Pichai
Published: January 2023

Choleragen, an antigenic, choleragenic moiety elaborated by some cholera vibrio strains in vitro, has been identified by disc immunoelectrophoresis as a protein migrating in a manner similar to human 7 S γ-globulin. Although preparations of choleragen have mucinolytic activity which is neutralized by antiserum against choleragen, the mucinase has been proven to be a separate entity which is not involved in the production of the diarrhea of experimental cholera. Similarly, it is choleragen, and not mucinase, which causes an increase of vascular permeability characterized by a delayed but sustained erythematous, edematous induration. Choleragen elaborated in vitro by an Ogawa serotype El Tor vibrio was serologically identical to that produced by the routinely used Inaba serotype classical cholera vibrio strain.
The Immunologic Response of Goats to Normal and Syphilitic Rabbit Testicular Tissue
Authors: Miller James N. , Bekker J. H. , DeBruijn J. H. , Onvlee P. C.
Published: January 2023

Goat immunization and absorption studies revealed that normal rabbit testicular tissue shares common “nonspecific” immobilizing and lipopolysaccharide antigens with virulent Treponema pallidum, Nichols strain and Treponema reiteri; reagin failed to develop in response to either the testicular tissue or the virulent treponemes.

Female goats injected intramuscularly with relatively large numbers of virulent T. pallidum, Nichols strain, showed no evidence of infection as measured by clinical observation, transfer and special straining of popliteal nodes, and antibody response.
The Separation and Characterization of Proteins Intrinsic to Nasal Secretion
Authors: Rossen Roger D. , Alford Robert H. , Butler William T. , Vannier Wilton E.
Published: January 2023

Antiserum prepared in rabbits against nasal washings of adult male volunteers has identified by immunoelectrophoresis six intrinsic components in nasal secretions in addition to the plasma proteins previously identified. Lysozyme activity was associated with one of these components, named on the basis of its electrophoretic characteristics, the N.W. γ2 component. Further characterization of nasal secretion lysozyme demonstrated that it is a basic protein of low molecular weight with sedimentation properties similar to those of crystalline egg white lysozyme.

γA-Globulin was the most abundant protein in nasal secretions and two types of this immunoglobulin, differing in molecular size, antigenic characteristics and relative abundance were found. The γA-globulin present in highest concentration had gel filtration properties indicating a molecular weight probably in excess of 200,000 and possessed antigenic determinants in addition to those found on γA-globulin of serum origin. A smaller amount of the γA-globulin present had antigenic characteristics and gel filtration properties closely similar to, if not identical with, those of serum 7S γA-globulin.

Influenza virus neutralizing activity and hemagglutination inhibiting activity were found exclusively in nasal wash fractions which contained γA-globulin as the only detectable protein. None of the other plasma or intrinsic components identified in nasal washings were associated with these anti-influenza activities.
In Vitro Studies on the Role of Collagen in the Induction of Hypersensitivity to Flea Bites
Authors: Michaeli D. , Benjamini E. , Miner R. C. , Feingold B. F.
Published: January 2023

Acid soluble collagen and in vitro collected saliva of fleas were allowed to react at pH 3.5, 7.2 and 10.6 Whereas all the activity of saliva is dialyzable, the nondialyzable products of the reactions at both the acidic and the basic pHs had the capacity to induce hypersensitivity to flea bites in recipient guinea pigs; the product of the reaction at neutral pH was not immunogenic.

The ratio between the amounts of saliva and of collagen was shown to be important in the production of immunogenic products.
Studies on Japanese B Encephalitis Virus Vaccines from Tissue Culture
Authors: Darwish Medhat A. , Hammon William McD.
Published: January 2023

The virulent OCT-541 strain of Japanese B encephalitis (JBE) virus grown in hamster kidney cell (HKC) monolayers and harvested in medium 199 containing 2% human albumin (H. Al.) at pH 7.1 was inactivated by heat and 1:4000 formalin at 30° and 37°C. The half-life of the virus was 14 and 5 hr at the two temperatures, respectively. The formalin inactivation curves at both temperatures were biphasic with the change in rate of inactivation occurring early in the reaction, within 2 hr. The reaction based on two trials appeared to proceed at a faster rate when carried out at pH 8.0 than at pH 7.0. The inactivation preparation when tested for potency by the mouse test gave a low, mean MID of 0.0033 ml (very high potency).

The virulent OCT-541 was similar to the OCT-541 attenuated strain in thermal stability and in the nature of the formalin inactivation curves. Nevertheless the potency of the wild strain was always two to three times better than that of the attenuated strain by the mouse MID test. When two inactivated lots of vaccine prepared simultaneously from the two strains were tested for potency, the potency of the wild strain was confirmed by the mouse test as 2.8 times better, and shown by the guinea pig antigen extinction test as 1.6 times better. The relative merits of the wild strain and the attenuated one for vaccine manufacture and use were discussed.
Properties of a Small Virus Associated with Adenovirus Type 4
Authors: Smith Kendall O. , Gehle Warren D. , Thiel John F.
Published: January 2023

One of our laboratory strains of adenovirus 4 was found to be contaminated with a virus having the following characteristics: it is small (18 × 21 mµ in diameter), angular in outline, probably icosahedral in symmetry, has a netlike capsid similar to reovirus, with about 100 antigenically reactive sites available on its surface, requires adenovirus for replication, suppresses the growth rate and ultimate yield of adenovirus in cell cultures, is serologically similar to another small virus from adenovirus 7 but distinct from one found associated with adenovirus 18, is structurally and serologically distinct from adenoviruses, and is stable to 60°C heating for 30 min, as well as to treatment with anionic detergent (SLS) and diethyl ether. These characteristics identify this agent as an adeno-associated virus (AAV), a member of a newly recognized group of small, defective DNA viruses (3, 4).
Host Dependence of Gdvii Virus: Complete or Abortive Multiplication in Various Cell Types
Authors: Sturman Lawrence S. , Tamm Igor
Published: January 2023

GDVII, a murine picornavirus, grows to high titers and produces extensive cytopathologic changes in cell cultures of hamster or mouse origin. Single cycle growth kinetics of this virus in BHK21 Syrian hamster kidney fibroblasts resemble those obtained with other picornaviruses: a latent period of 4 hr, doubling time of 10 to 12 min, and virus yield of 50 to 200 PFU/cell. Growth of GDVII virus in the BHK21 cell line is unaffected by D-2-(α-hydroxybenzyl)-benzimidazole (D-HBB) or guanidine. GDVII virus also produces cytopathologic changes in some other cell strains and lines of sheep, mouse, monkey, or human origin. In these systems, the multiplication of GDVII virus is defective and virus yields are limited to 0.5 to 5.0 PFU/cell.
Complement Associated Peptidase Activity of Guinea Pig Serum
Authors: Cooper Neil R. , Becker Elmer L.
Published: January 2023

Previous workers have demonstrated that hemolytic complement can be inhibited by peptides containing an aromatic amino acid and that C′3 is, in all likelihood, the inhibited component of complement. In the present study, EAC′1a,4,2a,3 have been shown to enzymatically hydrolyze glycyl-l-tyrosine as shown by the kinetics, pH optimum and dependence on concentration of cells and substrate. This peptidase activity is related to complement, and specifically to the presence of C′3 on the cells. However, EAC′1a,4,2a,3 cells prepared with partially purified C′3 have not been sactive enzymatically, with two significant exceptions. In these instances the C′3 was prepared by a variant of the standard procedure, and clear-cut implication of C′3 as the enzyme was obtained. Certain other data in this work indicate that the hydrolytic reaction is complex and point to a possible need for cofactor or enhancing substance for enzymatic activity. The search for such a factor is presented in the subsequent study.
DNA Synthesis in Mixed Cultures of Dog Leukocytes: Differential Effect of X-Radiation and Freeze-Thawing on Cellular Isoantigenicity
Authors: Main Raymond K. , Cole Leonard J. , Jones Marjorie J. , Haire Henry M.
Published: January 2023

A marked induction of DNA synthesis occurred in 50:50 mixed cultures of peripheral blood leukocytes derived from sets of allogeneic (Beagle and mongrel) normal dog donors. DNA-synthetic activity at selected times was determined by liquid scintillation counting following pulse labeling of cell populations with 3H-thymidine. In a typical experiment, DNA synthesis in mixed cultures attained a maximum value at the 6th day (61,000 cpm) followed by a steady decline thereafter (to 7500 cpm by day 9), as contrasted with control values (65 to 86 cpm). In leukocyte cultures of cells isolated and mixed on the same day, considerable DNA labeling (1900 to 3000 cpm) occurred at time 0. These values declined, (600 cpm at 18 hr; 230 cpm at day 2), and then rose later (2400 cpm at day 4). Incubation of individual cell suspensions for 18 hr prior to mixing eliminated the elevated zero time label.

X-irradiation (2500 rads) of one (or the other) of the cell components of the mixture changed the reaction from a “two way” to a “one way” immunologic reaction. When one (or the other) of a pair was frozen (-196°C) and thawed (37°C) three times and momentarily homogenized before mixing with intact allogeneic leukocytes, no induction of DNA synthesis occurred. These results suggest that leukocyte isoantigenic factors are not inactivated or destroyed by x-irradiation and can induce DNA synthesis in allogeneic leukocytes; whereas, they are labile to freeze-thawing. Our results are compatible with the known chemical and immunologic properties of transplantation antigens.
Antibodies against Staphylococcal Teichoic Acids and Type-Specific Antigens in Man
Authors: Daugharty Harry , Russell Martin R. , White Arthur
Published: January 2023

Antibodies against a large number of type-specific antigens and against teichoic acids were demonstrable in pooled concentrated human γ-globulin using Ouchterlony double diffusion plates. Antibodies against type-specific antigens a and i and against teichoic acids were frequently demonstrable in concentrated γ-globulins from the subjects without staphylococcal disease but could rarely be detected in unconcentrated sera from the same subjects. However, unconcentrated sera from subjects with active staphylococcal diseases frequently contained detectable antibodies against both teichoic acids and type-specific antigen a.
The Transfer of Allergic Thyroiditis in Histocompatible Guinea Pigs by Lymph Node Cells
Authors: McMaster Philip R. B. , Lerner Edwin M.
Published: January 2023

Strain 13 histocompatible guinea pigs were immunized with thyroid extract in Freund's complete adjuvant. Their lymph node cells were harvested and transferred intraperitoneally to recipient experimental strain 13 animals and to control Hartley guinea pigs. Twenty-eight per cent of the recipient strain 13 guinea pigs developed allergic thyroiditis, whereas only 4% of the Hartley strain developed the disease. These studies indicate that allergic thyroiditis may be transferred from immunized donors to histocompatible recipients by adoptive immunity.
Rhinovirus Neutralizing Antibody in Tears, Parotid Saliva, Nasal Secretions and Serum
Authors: Douglas R. Gordon , Rossen Roger D. , Butler William T. , Couch Robert B.
Published: January 2023

Virus neutralization studies were performed on tears, parotid secretions, nasal secretions, and serum obtained from 13 volunteers infected with rhinovirus 15. Neutralizing activity appeared in tears from 9 volunteers, in parotid saliva from 8 volunteers, in nasal secretions from 10 volunteers, and in serum from 13 volunteers. Studies with four volunteers revealed that neutralizing activity was detected first in serum; then and simultaneously in tears, parotid saliva and nasal secretions. Sucrose density gradient ultracentrifugation studies of specimens from two volunteers revealed that the predominant immunoglobulin in all three secretions was IgA and that in each secretion this immunoglobulin was associated with neutralizing activity. Although rhinovirus 15 was repeatedly recovered from nasal secretion specimens from each volunteer, none of the tear or parotid saliva specimens contained virus. Studies with an additional eight volunteers demonstrated that rhinovirus 15 could not be recovered from blood specimens obtained during incubation period, maximum virus shedding from the nasopharynx, or recovery.
Demonstration, Mass Production and Characterization of a Heavy Molecular Weight Human Interferon
Authors: Fournier Françoise , Falcoff Ernesto , Chany Charles
Published: January 2023

The present study demonstrates that it is possible to produce interferon in vitro using human amniotic membrane infected with various myxoviruses. Interferon of human origin thus can be obtained without cell culture. After viral inoculation, interferon is eliminated into the culture medium for approximately 5 days. In most instances a maximum yield is obtained 48 hr after viral inoculation. The yield of interferon is comparable to the yield of interferon produced by human leukocytes when Sendai virus is used as the inducing virus. Ultraviolet irradiation of the virus increases the yield of interferon. Optimal yields of interferon are obtained at pH 7.4 and at 37°C. The biophysical properties of this interferon are different from those described for leukocytes employing the same inducing virus. The molecular weight is estimated to be 160,000.

Although its mode of action has not been clearly defined like that of other interferons. HAM interferon acts during the vegetative phase of viral multiplication and for its action requires cellular RNA and protein synthesis.
Sensitization of Erythrocytes by Influenza Virus Antigen
Authors: Gorbunova A. S. , Sokovykh L. I.
Published: January 2023

The allantoic fluid of chick embryos infected with influenza virus A/PR8/34 possessed sensitizing activity which was detected using Boyden's passive hemagglutination test. The virus-specific antigen was revealed when antisera free of antibody to chicken proteins were used. Antisera obtained from rats immunized with influenza virus grown in chick embryos were found to detect the host-specific antigen.

The sensitizing influenza virus antigen proved to be soluble but it did not appear to be identical with the complement-fixing S antigen.

No cross-reactions in passive hemagglutination tests were found between A and B types of influenza virus, but A and A2 subtypes reacted in almost an identical manner.

Allantoic fluid infected with influenza virus retained its sensitizing activity after heating for 30 min at 70°C, but lost it at 100°C. Treatment for 2 hr by pepsin and trypsin in concentrations less than 2% did not affect the sensitizing activity of infected allantoic fluid. The sensitizing factor of infected allantoic fluid did not dialyze under conditions of the study.

The analysis of fractions recovered after ether disintegration of purified virus suggested the localization of sensitizing factor inside the virion. Failure to separate the sensitizing factor from the mixture of subunits in destroyed virus suspension was discussed.
Antigenic Structure of γE-Gobulin and Reaginic Antibody
Authors: Ishizaka Kimishige , Ishizaka Teruko , Terry William D.
Published: January 2023

Both κ and λ-chain antigenic determinants were detected in γE-globulin by radioimmunoelectrophoresis. In addition, γE-globulin has antigenic determinants which are lacking in other immunoglobulins of the four known classes, i.e., γG, γA, γM and γD as well as in γA- and γG-subclasses. The protein did not contain the major antigenic determinants of the four known classes of immunoglobulins. The results indicate that γE-globulin represents a distinct class of immunoglobulin.

Reaginic activity in atopic patients' sera was precipitated by anti-γE-antibody but not by either γM-anti-γM-antibody complexes or γG-antibody complexes containing γG2-, γG3- and γG4-globulins. The distribution of reaginic activity in chromatographic fractions did not parallel that of γG2- or γG3-globulin. Passive sensitization of human skin with reaginic antibody was not blocked by any of the myeloma proteins of known classes or subclasses, whereas a fraction containing γE-globulin had blocking activity. The results indicate that reaginic antibody activity is associated with γE-globulin.
Studies on Nucleoprotein Determinants for Systemic Lupus Erythematosus Serum
Authors: Stollar B. David
Published: January 2023

Serum of a patient with systemic lupus erythematosus (SLE) was examined in quantitative C′ fixation with deoxyribonucleic acid (DNA), nucleoprotein and a variety of histone-DNA complexes. At least two distinct determinants were found for this serum. Some of the antibodies reacted with a structure which was best formed by histone and native DNA, in a weight ratio of 3:1 or higher. Inhibition and absorption experiments indicated that native DNA itself contributed a major part of the antigenic determinant. Moderate aggregation may have been important in forming this structure, but extensive aggregation reduced its reactivity. Of the histone fractions, the lysine rich F1(A) was most effective in forming the antigen. A second type of determinant, which was best formed by the arginine rich F2a and denatured DNA, was not inhibited by free DNA, but was inhibited by excess of the free histone fraction.
Rapid Passive Transfer of Allergic Encephalomyelitis
Authors: Levine Seymour , Wenk Eugene J.
Published: January 2023

Passive transfer of living lymph node cells from donor rats with experimental allergic encephalomyelitis (EAE) to normal isologous recipients caused clinical signs of EAE after 3 to 7 days. Large doses of cells, or adrenalectomy of recipients, advanced the onset of clinical disease to 2 days after transfer. The combination of large doses of cells and adrenalectomy of recipients reduced the incubation period to 24 hr. There was an exponential relationship between dose of cells and incubation period in adrenalectomized recipients, possibly reflecting mitotic division of donor cells during the latent period.

Lesions of EAE produced by passive transfer localized in and around areas of the brain damaged by cyanide, as has been reported previously for EAE produced by active sensitization. Donor cells immunized against either isologous or heterologous central nervous system (CNS) antigens were effective. Localization was best when the cyanide was administered 1 to 4 days before the transfer. EAE was not produced when heat-killed encephalitogenic cells or living, stimulated but non-encephalitogenic cells were injected into cyanide-treated recipients, even when nonencephalitogenic cells were combined with serum from rats with EAE. Cyanide damage lowered the threshold for passively transferred EAE, probably due to reduction of the blood-brain barrier and/or increased accessibility of CNS antigens. Brain lesions caused by passive transfer of EAE to cyanide-treated recipients were detectable at 6 hr, well developed at 10 hr and maximal at 24 hr. This rate of lesion development was similar to that reported by others for development of delayed hypersensitivity reactions following passive transfer of tuberculin sensitized cells and separate, simultaneous injection of tuberculin. Because transferred cells are temporarily retained in the pulmonary filter, and because this obstacle was not overcome by injection into the carotid artery, it is likely that these results are close to the presently attainable limit for speed of detection of passive transfer of EAE.
Pembekalan Motivasi dan Muhasabah Serta Muroja’ah Para Penghafal Qur’an di Yayasan Arrahmani Ciputat Tangerang Selatan Banten
Authors: Eddy Saputra  , Arifin Muhammad , Muhajir Achmad
Published: January 2023

Menghafal Al Qur’an menjadi tujuan utama bagi para santri yang datang ke Lembaga atau pondok pesantren tahfidz. Banyak manfaat yang bisa didapat dari menghafal Qur’an dimana diantara adalah keberkahan al Qur;an serta ganjaran dari setiap huruf yang dibaca, belum lagi keuntungan yang bersifat duniawi. Banyak Lembaga Pendidikan yang memberikan beasiswa bagi para hafidz sampai berangkat Umrah gratis. Banyak metode yang diterapkan dalam mengahafal, masing-masing metode mempunyai kelebihan dan kekurangan. Tim pengabdian dari Universitas Indraprasta PGRI akan memberikan pembekalan kepada santri Pondok Pesantren Ar Rahmani dalam menghafal dengan memberikan Pembelakalan motivasi serta Muroja’ah sekaligus Muhasabah dalam mengahafal Al Qur’an. Metode pembelakan ini sangat sederhana dan mudah diterapkan bagi para santri pengahafal Qur’an dibanding dengan metode lainnya. Konsep yang dipelajari hanya mengulang-ulang dari setiap bacaan yang dapat dibenrengi dengan menggunakan media elektronik atau yang lainnya, jadi santri bisa megahafal dimana saja dan kapan saja tanpa harus khawatir hafalannya hilang. Dengan metode muroja’ah mengahafal menjadi mudah dan sederhana. Ini yang menjadi tujuan dari tim pengabdian masyarakat Universitas Indraprasta PGRI untuk melakukan pembekalan kepada para santri Pondok Pesantren Ar Rahmani di Ciputat Tangerang Selatan Banten.
Representaciones de contenidos, aplicaciones prácticas y relaciones interdisciplinarias como núcleo de coherencia en Educación Matemática.
Authors: Gamboa Graus Michel Enrique
Published: January 2023

Este artículo aborda conexiones significativas entre representaciones de contenidos matemáticos, sus aplicaciones prácticas y relaciones interdisciplinarias. El estudio empírico se realizó durante cinco cursos académicos, en instituciones acreditadas del Sistema Nacional de Educación de Cuba. Los miembros de la muestra fueron 121 profesores de Matemática titulados de la provincia de Las Tunas. Se utilizó una escala estadística y un software especializado para evaluar adecuadamente la coherencia en la enseñanza de la Matemática. Se diseñó un modelo adecuado en dos subsistemas (organización y planificación). Se favoreció el proceso establecido al trabajar con sistemas de representación interdisciplinarios a partir de relaciones contextuales.
Acreditación de la formación de licenciatura en modalidad a distancia en México: realidades, reflexiones y cuestiones.
Authors: Ponce Ceballos Salvador
Published: January 2023

El trabajo tiene como objetivo discutir la relevancia de la educación a distancia, así como reflexionar sobre la calidad de la educación en las modalidades educativas distintas a las presenciales y los cambios que es necesario llevar a cabo para asegurar su calidad. Se concluye que existe la necesidad de avanzar en el diseño de modelos de evaluación para la acreditación de programas a distancia, además de establecer mecanismos claros para identificar en los distintos padrones oficiales las modalidades en las que se acreditan los programas y también transparentar los procesos de evaluación y los resultados, así como su divulgación.
Inversión e importancia de los padres de familia a la educación en el nivel básico.
Authors: López García Pedro Damián , Hidalgo de la Cruz Verónica
Published: January 2023

El objetivo de la investigación que se presenta es conocer la percepción que tienen de la inversión en la educación los padres de familia de alumnos de nivel básico y cómo consideran el aprendizaje del inglés en comparación con otras asignaturas según la importancia que le dan. El universo fueron los padres de familia de los alumnos de quinto grado de una escuela primaria pública urbana, en el estado de Tabasco, México; a través de la estadística se calculó el tamaño de la muestra, aplicándose un instrumento de encuesta compuesta por 5 reactivos, conformados por variables cualitativas ordinales politómicas.
Uso del Deep Learning para analizar una aplicación web educativa sobre la estadística.
Authors: Salas-Rueda Ricardo-Adán , Sánchez-Rangel Joanna-Lizeth , Martínez-Ramírez Selene-Marisol , Ramírez-Ortega Jesús , Castañeda-Martínez Ricardo , Eslava-Cervantes Ana-Libia , Alvarado-Zamorano Clara
Published: January 2023

El objetivo general de esta investigación mixta es analizar las percepciones de los estudiantes sobre el uso de la Aplicación Web Educativa sobre la Estadística (AWEE), considerando la Ciencia de Datos. Esta herramienta tecnológica utiliza un simulador web para mejorar el proceso enseñanza-aprendizaje sobre la Prueba T. Los resultados del algoritmo Deep Learning indican que la interfaz web y estética de la aplicación AWEE influyen positivamente en la motivación de los estudiantes y el aprendizaje durante la pandemia COVID-19; asimismo, el algoritmo Árbol de decisión permitió determinar las condiciones predictivas de esta herramienta tecnológica. Por último, los avances tecnológicos facilitan la organización y realización de nuevas actividades escolares con la finalidad de mejorar las condiciones de enseñanza-aprendizaje.
La educación superior particular en tiempos de pandemia. Incertidumbre y vivencias de la academia.
Authors: Martínez Iñiguez Jorge Eduardo , Zúñiga Amaya Heidy Anhely , López Ramírez Evangelina
Published: January 2023

El objetivo del trabajo fue analizar la situación prevaleciente entre profesores de Instituciones de Educación Superior Particulares (IESP) en Mexicali, Baja California, México, durante la pandemia COVID-19. Se realizó un estudio cualitativo de tipo fenomenológico durante los meses de mayo a junio del 2020, donde se aplicaron entrevistas a profundidad a seis profesores pertenecientes a este tipo de instituciones. Los resultados obtenidos dan cuenta de la carencia de infraestructura y acciones concretas por parte de las IESP para garantizar de manera óptima la continuidad del servicio educativo, así como una desvalorización de la función docente en tiempos de contingencia sanitaria. Las IESP no han hecho una labor de apoyo hacia sus docentes, enfrentándolos a situaciones de estrés e incertidumbre.
Evaluación del bienestar emocional post-confinamiento en universitarios mexicanos de diseño digital: atendiendo los ODS 2 y 4.
Authors: Reyna-Castillo Miguel Ángel , Bucio-Gutiérrez Daniel , Calvillo-Villicaña María Eugenia , Cerda-Luque Pablo Alberto
Published: January 2023

Las universidades en su regreso presencial, atendiendo a los ODS 2 y 4 (salud y bienestar, y educación de calidad), deben de garantizar condiciones sanitarias seguras en términos de bienestar emocional, por lo que es fundamental un monitoreo fiable sobre el estado emocional del alumnado que regresa del confinamiento. El objetivo de este trabajo es evaluar el bienestar emocional post-confinamiento en universitarios del área de diseño digital, caso representativo de Tamaulipas, México. La metodología fue empírica estadística (n=144) adaptando la Escala MDO de Uribe-Prado a estudiantes. La validación de las medidas fue con técnica de Mínimos Cuadrados Parciales (PLS). La priorización de los pesos de las gráficas de Pareto pone en primer lugar al desgaste emocional y a la somatización.
Representaciones sociales de la investigación científica en estudiantes de postgrado en enfermería.
Authors: Garay Núñez Jesús Roberto , Jiménez Barraza Verónica Guadalupe , Santos Quintero María Isabel , Zamora Castro José Casimiro , Beltrán Montenegro María del Carmen , Gutiérrez Ruiz Francisca
Published: January 2023

El objetivo del trabajo es identificar las representaciones sociales de la investigación científica y de la investigación científica en enfermería en estudiantes de maestría de dos universidades públicas de México. Como estrategia metodológica se utilizaron las redes semánticas naturales. Se determinó que el núcleo figurativo de la representación social contempla dos conceptos principales como el centro de la representación: el conocimiento y la innovación, seguidas de los conceptos de cuidado y humanismo.
Estudio bibliométrico de la geografía de la producción científica en México en el campo de la piscología.
Authors: Luna Morales María Elena , Luna Morales Evelia
Published: January 2023

Se analiza la producción científica de México en el campo de la psicología, a partir de la literatura registrada en las bases de datos Web of Science y Scopus. La búsqueda de publicaciones se llevó a cabo, combinando el campo de disciplina científica y el país en el periodo 1900-2021. El estudio se basa en el método bibliométrico cuantitativo para determinar la distribución de las publicaciones y citas por regiones. En los años 40 se dan a conocer los primeros trabajos, la década de los 70 señala publicaciones continuas; en los 90 se incrementa la producción y en los 2000 se consolida el campo de estudio. Las regiones Centro Sur y las del norte son las principales productoras de la literatura registrada.
Participación ciudadana en el presupuesto participativo municipal de Chaclacayo de la Provincia de Lima.
Authors: Cerna Luna Oscar Carlos , Cerna Apaza Oscar Erick , Tarmeño Bernuy Luis
Published: January 2023

Este estudio tuvo como propósito evaluar la participación ciudadana en el presupuesto participativo en la gestión municipalidad distrital de Chaclacayo de la Provincia de Lima 2019, y el mismo surge, porque los agentes involucrados de esta localidad señalan que la participación ciudadana en esta región es deficiente. Se trabajó con la metodología de investigación no experimental, porque solo se estudiaron las variables a nivel teórico y se encuestaron a los actores en su contexto natural. Los resultados obtenidos permitieron concluir que la participación ciudadana en el presupuesto participativo de esta región es deficiente; esto debido a que la gestión municipal no se involucra, ni motiva a sus trabajadores a comprometerse en los asuntos de la gestión pública.
Gestión municipal y el desarrollo sostenible en el Distrito de Santa Anita, Perú, en el marco de la descentralización.
Authors: Yauri Misari José Stalin , Ayala Yauri Beatriz , Ayala Yauri Pedro , Yauri Neyra Arnold
Published: January 2023

La gestión municipal y el desarrollo sostenible en el marco de la descentralización constituyen herramientas importantes para el desarrollo de Santa Anita en Perú; por ello, el presente estudio tuvo como objetivo realizar una revisión bibliográfica sobre las ventajas de la gestión municipal para un desarrollo sostenible para esta localidad basándose en experiencias previas, normas y políticas nacionales e internacionales. Se trabajó con la rigurosidad que exigen las investigaciones científicas de carácter no experimental y analizaron diferentes entornos a las variables de estudio. En las conclusiones se destaca la importancia de desarrollar buenas estrategias de gestión municipal a favor de un desarrollo sostenible en sus tres dimensiones: economía, social y ambiental en la localidad mencionada.
Incumplimiento en la regulación del sistema de participación ciudadana por parte de los GADs de las parroquias rurales del cantón Pasaje.
Authors: Mendía Nagua Jessenia Elizabeth , Moscoso Parra Ruth Karina
Published: January 2023

El objetivo de la investigación fue Determinar cómo el incumplimiento de las normas constitucionales en la participación ciudadana por parte de los GADs Parroquiales Rurales ha generado una deficiente participación de los ciudadanos en los asuntos públicos, respecto a la planificación, gestión y control, de los GADs Parroquiales del cantón Pasaje. Los resultados muestran que existe un desconocimiento tanto de la ciudadanía como de las autoridades en cuanto a la participación ciudadana y su impacto en la gestión de gobierno. La participación ciudadana debe ser promovida desde las propias comunidades; sin embargo, se requiere el fortalecimiento del diálogo asertivo comunidad-autoridades como estrategia ante las demandas sociales; especialmente, en la formulación del presupuesto participativo.
La implicación jurídica de reconocer a los animales como objetos de comercialización.
Authors: Piray Rodríguez Paúl Orlando , Urquizo Orozco Jessica Alejandra , Narváez Inca Gisella Carolina
Published: January 2023

La Constitución del Ecuador estableció el reconocimiento de la naturaleza como sujeto de derechos; esto representa una gran innovación jurídica, ya que no solo se velan por la protección y bienestar de las personas sino también de todos los organismos vivos del planeta. La investigación tiene como objetivo que se generen normas que garanticen la defensa y cuidado de todos los seres vivos, y que el Estado tiene la obligación de ajustar sus políticas públicas y sus leyes para que se cumpla el pleno derecho de todos los animales como seres sintientes que tienen derechos y deben ser protegidos íntegramente, analizando el artículo 585 del Código Civil ecuatoriano, a la luz del neoconstitucionalismo.
La anemia, desnutrición crónica infantil y la educación en zona rural bajo una política pública por la COVID-19.
Authors: Pedraza Diaz Eduardo Rennie , Cieza Paquiyauri Franklin Pedro , Mejia Vega Thalia Dora , Mungarrieta Virguez Cruz Rafael de la Coromoto
Published: January 2023

La investigación se desarrolló en el departamento de Huancavelica, provincia y distrito de Churcampa, el mismo que cuenta con una población general de 35,654 habitantes, 11 distritos, 325 comunidades, barrios y caseríos. El estudio detalló las características de problemas de salud hallados en la población como la anemia y Desnutrición Crónica Infantil (DCI) en el rango de edad, menores de 5 años y también de madres gestantes. Tuvo un enfoque cuantitativo, con diseño descriptivo comparativo, buscando medir las variables del contexto con el único fin de analizar los datos obtenidos y establecer conclusiones asociadas. Se utilizó la descripción como forma sistemática de definir y precisar los hechos utilizando técnicas como la observación y la encuesta mediante una muestra censal.
Violencia en Mujeres Trabajadoras Sexuales: Revisión Sistemática.
Authors: Gómez Rodríguez Gustavo Alfredo , Apodaca Armenta Rosario Eduardo
Published: January 2023

Los principales factores de violencia en las mujeres trabajadoras sexuales son la violencia física, emocional o sexual por parte del cliente en el lugar de trabajo y/o la policía; además, sufren violencia por discriminación en los servicios de salud, carecen de acceso a los servicios, y la negación a recibir atención médica por el personal de salud. Se realizó la revisión documental con los lineamientos de la declaración PRISMA, se incluyeron artículos de investigación en inglés y en español, y se construyeron cadenas de búsqueda. Las bases de datos utilizadas fueron EBSCO, PUBMED, WEB OF SCIENCE, SCOPUS, CINAHL y GOOGLE ACADEMICO. Se concluye que existe violencia hacia las trabajadoras sexuales que indicen directamente en su salud física, emocional y sexual.
Capacidad intelectual, visomotricidad y emociones en escolares de primaria con Bajo rendimiento.
Authors: Sánchez Domínguez Juan Pablo , Pozo Osorio Merari Cristel
Published: January 2023

Con el objetivo de caracterizar los factores psicológicos: Capacidad intelectual (Ci), Visomotricidad y Emociones en una población de escolares de nivel primario con Bajo rendimiento escolar (Bre), se evaluaron las variables mencionadas mediante una batería de pruebas psicológicas. De los resultados más destacados se tiene, que en el factor Ci, el 32.7% de los participantes mostraron niveles bajos, en lo concerniente a las emociones, el 53.4% de la población no presentaron niveles considerados significativos para perturbación emocional, y finalmente, en cuanto a la función Visomotora, el 56.0% manifestaron niveles bajos. Se concluye, que la muestra de participantes con Bre presentaron niveles emocionales estables, mientras que la capacidad visomotora está mayormente disminuida.
Uso de herramientas tecnológicas para tratar trastornos psicológicos alimenticios que afectan a universitarios.
Authors: Culque Toapanta Walter Vinicio , Lalama Flores Marcos Aníbal , Suárez López Andrea Gabriela
Published: January 2023

El objetivo del estudio es analizar el efecto negativo de la pandemia en estudiantes universitarios, en especial en el ámbito alimenticio, en el cual muchos están sufriendo de malas conductas alimenticias. Los estudiantes con trastornos de conducta alimenticia aumentaron significativamente durante la pandemia, trastornos que causan en los estudiantes bajo rendimiento académico y síntomas depresivos, pudiendo llevarlos al suicidio. Se pudo obtener datos necesarios para la investigación mediante diagnósticos a pacientes con trastornos psicológicos alimenticios, concluyéndose que las tecnologías de información y comunicación se han convertido en una gran solución para muchos problemas actuales, y que las herramientas digitales permiten prevenir las recaídas y ayudar a los estudiantes en los efectos colaterales que ha tenido esta pandemia.
La humanización en salud para promover la descentralización en los centros de salud.
Authors: Pachas Cotos Yris
Published: January 2023

Este estudio surge de la preocupación de los aspectos críticos del sistema de salud en Perú, como la ausencia de recursos, poca capacidad del personal en la resolución de conflictos y la falta de empatía hacia el paciente, lo que evidencia una deshumanización de este sistema y la necesidad de humanizarlo. Para dar respuesta a esta situación se exponen en este artículo algunos modelos que pueden contribuir a la humanización de los servicios de salud, teniendo en cuenta los diferentes agentes que participan en la asistencia médica. Se trabajó con la metodología de investigación documental. Entre las conclusiones se destacó la importancia de que el estado, los centros y el personal de salud aborden esta problemática de forma mancomunada.
Estandarizar el aislamiento de linfocitos T CD4+ de memoria para evaluar el efecto mediado por 1,25 (OH)2 Vitamina D3 mediante el análisis de factores transcripcionales y producción de citoquinas.
Authors: Llerena Toro Faryd Javier , Ormaza Cevallos Rober Ramon , Artieda Moreno Lisseth Estefania , Navarrete Sornoza Danilo Adrián
Published: January 2023

El objetivo del estudio es estandarizar el aislamiento de linfocitos T CD4+ de memoria para evaluar el efecto mediado por 1,25 (OH)2 Vitamina D3. Para llevar a cabo esta investigación, se extrajeron linfocitos T helper de memoria de sangre periférica y se activaron con anti-CD3/CD28 en presencia o ausencia de Vitamina D. Se determinaron los cambios en la diferenciación de los linfocitos T CD4+ de memoria, analizando la expresión de factores de transcripción y la producción de citoquinas por citometría de flujo. Los resultados demostraron los cambios que se producen sobre la diferenciación de linfocitos T CD4+ de memoria en cuanto a los perfiles de producción de citoquinas. En conclusión, los linfocitos T CD4+ en presencia a la Vitamina D modula diversos procesos.
THE SCHOOL PRINCIPAL - A LEADER. ONE EXPERIMENT AND 12 TIPS TO HELP YOU SUCCEED
Authors:   KONSTANTIN PRESLAVSKY UNIVERSITY OF SHUMEN, Pavlov Pavel
Published: January 2023

In the face of fierce competition between schools, the headmaster of a successful school can and should be compared to a military commander. To lead a pedagogical team is an art and as such, it cannot be explained. Without pretending to be comprehensivene and without redundant theorizing, I offer a simple test and 12 tips in which the wisdom of military and political leaders from ancient times to the present day, refracted through my 20 years of management experience, will help you be on the winning side.
Geochemistry, Depositional Environment, and Provenance of the Cretaceous Radiolarian Chert in Northeastern Kurdistan, Iraq
Authors: Al-Sheraefy Ruaa , Ahmed Falah , Alrashedi Mohamed
Published: January 2023

The radiolarian chert rocks are one of the most important indications of the existence of ophiolites because they are a source of silica supply. These rocks have been studied to refute and reject the idea that ophiolites do not existed. The Si/(Si+Al+Fe+Ca) ratio in the radiolarian chert indicates that the silica is of biogenic origin and adds SiO2 from the shale fraction through diagenetic processes. The high values of Fe2O3 content indicate the hydrothermal effect during precipitation. This effect is controlled by the distance between the sediments and the mid-oceanic ridge or sea floor metamorphism. The phosphorus could be a direct result of volcanic activity associated with ophiolitic rocks, whereas, the negative correlation coefficient of phosphorous with calcium (r = -0.53) supports the idea that the source of phosphorous is volcanic activity that is not related to the carbonate fluorapatite mineral. REEs shows a basic difference as a positive cerium anomaly in section Q2 and a negative cerium anomaly in section Q1. The Al-Fe-Mn diagram shows that all samples fall into the field I non-hydrothermal zone, but in the SiO2 vs Al2O3 diagram the samples of the Q1 section fall into the hydrothermal field, and samples of the Q2 section fall into the non-hydrothermal field. The input materials in Qulqula radiolarian chert come from terrigenous sediments in both sections. On the other hand, the Al/(Al+Fe+Mn) ratio range, (between 0.61 to 0.70), is very close to the average shale composite value, (0.6.19), which may reflect the contribution from continental and non-hydrothermal sediments, while the lower values of this ratio reflect hydrothermal source input. The MnO2 /TiO2 ratios ranged between 0.06 to 2.37 in section Q1 which represents typical characteristics of the deep ocean, trenches, and basaltic plateau sediments.
Membumikan Moderasi Beragama “Ikhtiar dalam Mewujudkan Masyarakat Cinta Damai”
Authors: Syarifudin Syarifudin , Khatami M.
Published: January 2023

In early 2019, the Ministry of Religious Affairs through the National Working Meeting at the Sherton Hotel Jakarta issued three main taglines, namely religious moderation, community togetherness and data integration. One of the three taglines, namely religious moderation, is then systematically a leading program that frames all kinds of religious policies, which are based on the ideas and attitudes of washatiyatul Islam. Religious moderation is very important in religious and state life. For the Indonesian people, religion means we are Indonesian, and being Indonesian means we are religious. Religious moderation is a means for the realization of harmony, harmony, peace, and benefit in achieving common ideals towards a just Indonesia in prosperity. In line with the national ideals stated in Pancasila and the 1945 Constitution.