bluuebunny/crossref_metadata_2025 huggingface dataset:
DECISION TREES IN CLASSIFICATION TASKS
Authors: Stirna Lauris , Kodors Sergejs
Published: May 2022

The goal of the study is to develop a classification system for Iris dataset. The analytical development environment called KNIME and freely available Iris dataset were applied in the research. The developed classification is based on the decision tree application. The accuracy of decision tree is compared with artificial neural network.
RISK ANALYSIS OF DIGITAL LOAN COMPARISON PLATFORM
Authors: Ščetilnikova Jelena , Kodors Sergejs
Published: May 2022

Advanced technologies can improve the efficiency of business processes, but incorrect system implementation can also become a huge source of damage. Therefore, the issue of IT security is very important. The concept of IT security has many aspects. One of them is security risk analysis, which must be considered by each system developer. The article describes one of the risk analysis methods - the CORAS method. The goal of research was to complete the risk analysis of the loan comparison platform. As a result, the risk mitigation recommendations were developed.
SMART HOUSE OPPORTUNITIES IN PRESENT
Authors: Šperga Āris , Grabusts Pēteris
Published: May 2022

The author performed an analysis why testing is important for e-commerce application. The work contains basic information about testing, software development and e-commerce.
DEEP LEARNING FOR APPLE AND PEAR RECOGNITION
Authors: Žukovs Vitālijs , Apeināns Ilmārs , Kodors Sergejs
Published: May 2022

The aim of this work is to develop a neural network, which can recognize apples and pears. To achieve the goal, the authors applied AlexNet architecture and the open dataset “Fruits360”. The trained model showed a good result testing it on validation images - total accuracy 0.97 and latency 35ms/step. In the future research, authors consider training the neural network model using the MobileNet architecture and verify it using the Cohen`s Kappa coefficient.
INVESTIGATION OF THE INFLUENCE OF POWER AND SPEED IN CO2 LASER ENGRAVING ON GLASS
Authors: Bluks Artis , Rabkeviča Kristīne , Vasaraudzis Raivo , Lazov Lyubomir
Published: May 2022

Laser technologies are a major priority in the development of our economy and society in the 21st century. One of the main applications of lasers is laser marking / engraving. The laser engraving method is widely used in many industries, including the glass industry. There are many ways to engrave glass, for example sandblasting, but it is time consuming, expensive and not as precise as laser engraving. The report contains glass engraving quality with CO2 laser, using different power and speed values.
LATGALES CERAMIC ENGRAVING WITH CO2 LASER
Authors: Petrovs Aleksejs , Adijāns Imants
Published: May 2022

The paper discusses the need for a more accurate understanding of the results for certain laser parameters when engraving a material such as ceramics. For engraving the SUNTOP ST-CC9060 CO2 laser system was used and for measuring the OLYMPUS OLS5000 laser microscope was used. The objective of the experiments was to determine how engraving depends on the laser power and scanning speed.
The state of neurorehabilitation service and prospects of its development in the republic of tatarstan
Authors: Yamaleev R. G. , Ismagilov M. F. , Galiullin F. G.
Published: May 2022

Actual aspects of rehabilitation of the patients with long-term disability and the invalids of the Republic of Tatarstan are presented. Structure of the causes of nervous system lesions causing the disability and invalidism, is shown. Critical evaluation of the rehabilitation service, origining in the Republic and of its basis is given. The main components of this service should be: a network of rehabilitation institutions equipped with up-to-date appu- ratus and equipment; specialists in the field of rehabilitation armed with a scientific-based programme of rehabilitation and with evaluative criteria of its effectiveness. The necessity of the creation of the republican public coordinative rehabilitation Council is emphasized.
Rehabilitation of mental patients and invalids in the republic of tatarstan
Authors: Mendelevich D. M. , Khalitov I. M. , Evplov V. A.
Published: May 2022

Features of rehabilitation work with mental patients are stated, the necessity of carrying out this process stepwise, special importance of resocialization of patients are mentioned. The analysis of rehabilitation service in the Republic of Tatarstan is given, advantages of semistationary forms of treatment are pointed out, especially to prevent hospitalism. The conclusion has been made that the former mental patient rehabilitation system was negatively influenced by the crisis in the system's structure, when special workshops for invalids at enterprises were closed due to social and economical difficulties. The question is raised on the necessity of elaborating a state programme for mental patient and invalid rehabilitation.
Memory disorders in patients with early signs of cerebrovascular insufficiency
Authors: Lebedev А. А. , Gapeeva L. S.
Published: May 2022

The results of short-term verbal memory and associative memory study of 40 patients with early signs of cerebrovascular insufficiency and 20 normal persons with registration on phonoosciilogram are described. Decrease of the both kinds of memory, changing of some time parameters of memorizing processes (duration of latent states, decrease of rate of adaptation, changing of uniformity and equilibrium of time parameters) were found in patients with early signs of cerebrovascular insufficiency. The analysis of short-term verbal memory dynamics makes it possible to differentiate between normal and pathologic states. Investigational findings may be used in rehabilitation of middle-aged and elderly patients.
About the factors influencing the indicators of social prognosis in mental illness
Authors: Khokhlov L. K. , Gavrilov V. V. , Savelyev L. N. , Gorokhov V. I.
Published: May 2022

The results of clinical and epidemiological research are given (506 patients were examined). The analysis has shown that social involvement prognosis depends not only on the pathology character but also on the practice of mental patient working ability evaluation, on cultural and social factors which are especially important at the present period of historical development of our country. The number of working patients tends to lower while the number of patients recognized as invalids has increased. The conclusion has been made that a social involvement prognosis in psychiatry relates with many factors while factors of clinical and biological nature can obtain social meaning, and it should be taken into account in evaluating the influence of up- to-date patient conducting methods on patient fates.
Psychopharmacotherapy of mental disorders in patients with chronic pain
Authors: Hamburg L. A. , Livschitz L. Y. , Crom V. L. , Yampolsky L. B.
Published: May 2022

Findings of psychopathologic examination of 134 patients with chronic pain syndrome are given. Variants of verging mental pathology, arising in persons with chronic pain syndrome, their correlation with duration of pain syndrome and premorbid personal peculiarities of patients are described. Principles of individual use of psychotropic drugs in the described category of patients, taking into account the structure of mental disorders, are proved.
Some clinical and social-psychological aspects of reablement in solitary elderly mental patients
Authors: Druz V. F.
Published: May 2022

The results of examination of solitary elderly unadapted mental patients are given. Of great interest might be description of variants in loneliness taking by patients, which depend on nosologic forms of disease and social- psychological components of a patient state. In particular, it was definitely shown that the majority of schizophrenics took loneliness as a positive thing, while patients suffering organic lesions or maniac-depressive psychoses took it as a negative one. It is noted in the paper that such patients are all more or less unadapted socially and need a special complex reablement programme.
Organization of drug supply for patients with neuropsychological rehabilitation in the context of the transition to market relations
Authors: Safiullin R. S. , Gazizova N. T.
Published: May 2022

In the Republic of Tatarstan, at present, the provision of medicines and medical products is mainly carried out by the state enterprise "Tatar stan pharmacy", which includes the republican pharmacy base, the Center for Controlling the Production and Quality of Medicines, the Republican Information Center, and a reference and information service for the population (003), as well as 298 self-supporting pharmacies, including 193 rural, 5 interhospital, 3 hospital pharmacies.
Back pain: evolutionary aspects and problems of rehabilitation
Authors: Ivanichev G. A. , Lewit K.
Published: May 2022

Existing ideas about the obligatory accompaniment of degenerative-dystrophic changes in the spinal motion segment (SDS) by clinical syndromes of the lesion are currently considered erroneous. Sanogenetic reactions of the whole organism in response to a change in the load on a separate SMS cause initial functional and subsequent structural changes.
Dynamics of clinical manifestations of myofascial trigger points. In the rehabilitation of patients with ankylosing arthritis with pondylo
Authors: Parsanov S. A. , Ivanichev G. A.
Published: May 2022

In recent years (Prague), scientific and practical interest in the problems of diseases with ankylosing spondylitis has increased significantly. During the development of the disease, when stiffness of the spine and joints occurs, but ankylosis (stages of preankylosis) has not yet been detected, pain syndromes and muscle spasms prevail in development, the mobility of the chest and joints increases significantly, and foci of changes are not detected.
Information support of medical science and practical healthcare
Authors: Dresher Y. N.
Published: May 2022

A well-established system of scientific information is one of the conditions for the successful development of medical science and practical public health. The extreme workload of doctors with daily current work, the inability to independently follow all the latest special literature make it necessary to help information services.
Gas Leakage Detection System with Alarming System
Authors: Baballe Muhammad Ahmad , Bello Mukhtar Ibrahim
Published: May 2022

This system aims to present a design that can automatically detect, alarm, and control gas leakage using an exhaust fan to suck the gas away from the premises where there is leakage. This system detects the nature of gas using LEDs (red and green). The alarm gives a sound when gas leakage is detected, the exhaust fan sucks the gas away from the premise, and the Liquid Crystal Display (LCD) indicates the system performance at any distortion condition. The Arduino UNO is used as the main controller of the system, and the buzzer is used as a means of notification. One of the prophylactic means to stop accidents related to this gas leakage is to mount a gas leakage monitoring device in susceptible places. The system will detect the leakage of liquefied petroleum gas (LPG) using a gas sensor and use the buzzer to alarm the industries, companies, or people about the leakage. The system also consists of two indicators (LEDs). The Green LED used in this research indicates no gas detection, that is, there is no gas leakage in the environment, and the red LED will indicate that there is gas leakage detected. The device is intended for use in household safety where appliances and heaters that use natural gas or LPG may be a source of risk. The system can also be used for other applications in the industries or companies that depend on LPG and natural gas in their operations.
Digital HR: A study on how game-based assessments can attract talents
Authors: Gürbüz Uğur , Afacan Fındıklı Mine , Özdemir Şebnem
Published: May 2022

Today, “Talent Gap” poses as one of the biggest problems in the business world. As the ratio of this talent gap increases, so too does the desperation of businesses to alleviate this problem. This study aims to answer the research problem defined as, “Does using game-based assessment provide an advantage to companies in the war of attracting and retaining young talents?” To answer this, the aptitudes and perspectives of 35 candidates towards the companies in terms of some criteria were measured by means of Analytic Hierarchy Process. In conclusion, this study shows that the companies, offering game based assessment, witnessed a 72 percent more advantageous situation than companies offering traditional assessment tests.

Keywords: Game Based Assessment, Traditional Assessment, Digital HR, Talent Acquisition
E-learning system of teaching english language
Authors: Salama Ramiz , Chiparausha Krell , Bsatar Faysal
Published: May 2022

The use of E-learning platforms for education in recent times has been on the rise. The purpose of this work is to provide an overview of the web application. This paper provides an overview of a web-based application as a result of the project titled “22nd Century English”. This is a web platform that arranges schedules and scheduled video conferences between students and lecturers. A lot of teachers especially English Teachers have extra time with which they can teach but without commitment, because of their commitment to their Teaching Institution. With the opportunity to handle freelance lessons through the developed application, teachers have the ability to earn extra income while helping other students outside their schools.  This platform also helps students to learn English remotely without wasting time with traveling or intense commitment.
 
Keywords: E-learning; English teaching; learn press; LMS.
 
 
Keywords: LMS, learn press, e-learning, English teaching, efficiency of English learning;
Ethical challenges in vascularized composite allotransplantation of the lower extremity: lessons learned from hand transplantation and implications for the future
Authors: Xu Amy L. , Humbyrd Casey Jo
Published: May 2022

Vascularized composite allotransplantation (VCA) is a novel surgical practice that involves the transplantation of multiple tissue types as a functional unit without the primary purpose of extending life. While VCA of the upper extremity is becoming increasingly accepted and performed, VCA of the lower extremity remains largely unexplored despite its acknowledged potential value. There are inherent ethical concerns surrounding VCA that are dominated by a conflict between the principles of beneficence and maleficence. The primary question is whether the quality-of-life benefits to the patient outweigh the risks associated with long-term immunosuppression for a non-lifesaving procedure. In addition, the ethical conversation involves concerns regarding informed consent, donor autonomy, patient privacy and public disclosure, patient selection, and unique considerations in the pediatric patient. Lower extremity VCA has additional ethical issues compared to upper extremity VCA, as current lower limb prostheses provide excellent, near baseline function that upper limb constructs have not yet been able to achieve. In this review, we discuss the ethical challenges of lower extremity VCA using available evidence for the upper extremity. We also compare ethical considerations of VCA of the extremity with other surgical alternatives to limb loss - namely, limb salvage and replantation - and address how the conversation may be altered with further advancements in immunosuppression and prosthetic technology.
Combined grafts and flaps in urethral stricture repair
Authors: Dávila Francisco , Rosito Tiago , Stojanovic Borko , Martins Francisco E.
Published: May 2022

Although urethral strictures have been known since antiquity, the surgical management of urethral strictures has undergone a great (re)evolution over the last six decades, both in the perception of the disease and in the surgical repair techniques, always presenting itself as a challenge for the surgeon and patient. Reconstruction of urethral stricture disease involving a combination of grafts and flaps consists of a group of complex procedures with specific clinical indications. The knowledge of these procedures by reconstructive urologists is both necessary and relevant. A thorough understanding of the anatomy, including blood supply, is a crucial proviso for the correct evaluation and successful management of urethral stricture disease. We discuss the main techniques and indications in combined graft and flap urethroplasties.
The evolution of lower extremity reconstruction
Authors: Evans Brogan G. A. , Colen David L.
Published: May 2022

Reconstruction of the lower extremity is a complex task that has evolved greatly in both technique and indication over the past century. Early advances in treating traumatic lower extremity injuries focused on primary amputation to avoid the high mortality of infection. The introduction of antibiotics improved surgical debridement and local reconstructive options, enhancing the viability of lower extremities with simple and proximal defects. With the advent of microvascular surgery, free tissue transfer techniques provided a means to reconstruct more distal and complex problems. As these surgical techniques have continued to evolve, so too have indications for reconstruction, patient management and post-operative care-now with a greater emphasis on patient quality of life and limb function. The purpose of this article is to outline the evolution of lower extremity reconstruction, and how the standard of practice has changed over time.
The pros and cons of biological effects of herbs and herb-derived compounds on liver tumorigenesis
Authors: Khalil Mohamad , Calasso Maria , Bonfrate Leonilde , Di Ciaula Agostino , De Angelis Maria , Wang David Q. H. , Portincasa Piero
Published: May 2022

Consumption of natural products such as herbs, spices, plant-derived compounds, and foods is on the rise globally. The use of these substances is widely recognized as an integral part of culture and tradition, with the philosophy being “no benefit is no harm”. The utility of medicinal plants and extracts is under scrutiny, and the scientific community needs to clarify many conceptual gaps. Medicinal plants are rich in bioactive phytochemicals that produce chemopreventive effects at different levels, including cellular, animal, and clinical. The ultimate translational value is often missing, and some studies suggest that botanicals may contain toxic compounds that cause acute or chronic toxicity. In this regard, the liver is the center, and herbal products can show protective effects or induce hepatotoxicity, thereby promoting liver cancer. In this review article, we examine a range of herbal products implicated in hepatocarcinogenesis and extend the discussion to herbal products that may be potentially involved in the prevention and treatment of liver carcinoma.
Venetoclax resistance: mechanistic insights and future strategies
Authors: Ong Faustine , Kim Kunhwa , Konopleva Marina Y.
Published: May 2022

Acute myeloid leukemia (AML) is historically associated with poor prognosis, especially in older AML patients unfit for intensive chemotherapy. The development of Venetoclax, a potent oral BH3 (BCL-2 homology domain 3) mimetic, has transformed the AML treatment. However, the short duration of response and development of resistance remain major concerns. Understanding mechanisms of resistance is pivotal to devising new strategies and designing rational drug combination regimens. In this review, we will provide a comprehensive summary of the known mechanisms of resistance to Venetoclax and discuss Venetoclax-based combination therapies. Key contributing factors to Venetoclax resistance include dependencies on alternative anti-apoptotic BCL-2 family proteins and selection of the activating kinase mutations. Mutational landscape governing response to Venetoclax and strategic approaches developed considering current knowledge of mechanisms of resistance will be addressed.
Preparation and application of 0D, 2D and 3D molybdenite: a review
Authors: Zhan Weiquan , Yuan Yuan , Liu Chang , Chen Peng , Liang Yumeng , Wang Yu , Arauz-Lara José Luis , Jia Feifei
Published: May 2022

Molybdenite (MoS2) has been widely used in the fields of catalysis, desalination, energy storage and conversion and optoelectronics as a result of its unique crystal structures and unusual properties. In the last decade, the modification of the surface, structural and semiconducting properties of zero-, two- and three-dimensional (0D, 2D and 3D) MoS2 for enhanced applications has attracted considerable attention. In this review, we summarize the synthesis, modification methods and application of 0D, 2D and 3D MoS2. The unique structures and properties of 0D, 2D and 3D MoS2 are first introduced. Next, the preparation methods of 0D, 2D and 3D MoS2 are summarized. The modification methods, including surface, structural and composite engineering, for enhancing the physical and chemical properties of 0D, 2D and 3D are also discussed. Finally, inspired by natural and modified MoS2, future suggestions for the design of novel 0D, 2D and 3D MoS2 for various applications are also suggested. This review offers new insights into the design and construction of novel and efficient 0D, 2D and 3D MoS2 for practical applications.
MEDIA DAN DIGITALISASI GERAKAN SOSIAL: AKTIVISME K-POPPERS DI TWITTER DALAM MERESPON KAMPANYE TRUMP TAHUN 2020 DAN BLACK LIVES MATTER
Authors:   Universitas Islam Indonesia, Yogyakarta, Sidik Anwar Maulana , Rizky Zuliyan M ,   Universitas Islam Indonesia, Yogyakarta
Published: May 2022

Globalisasi hadir memberikan banyak tempat bagi segala perkembangan zaman, salah satunya adalah perkembangan sarana komunikasi yang semakin masif dan tidak lagi mengenal batasan. Hal demikian tentunya memberikan pendekatan aktivitas yang sebelumnya dilakukan secara konservatif, berubah menjadi pendekatan yang modern. Salah satu gejala yang terlihat adalah muncul arus utama kekuataan para penggemar atau fandom di media sosial. Pecinta musik Korean Pop atau yang sering disebut juga sebagai K-Poppers, selain berperan sebagai penggemar, namun kini juga menjelma dalam melakukan berbagai aktivitas gerakan sosial secara daring di berbagai platform media sosial. Bahkan, dorongan gerakan sosial daring yang dilakukan oleh K-Poppers ini mampu mempengaruhi realitas sosial yang terjadi di dunia nyata. Sehingga, tujuan dari penelitian ini yakni guna mengetahui dan menjelaskan bagaimana pola aktivisme gerakan sosial yang dilaksanakan oleh K-Poppers secara daring dengan memaksimalkan media sosial. Terkait dengan media sosial, tulisan ini berfokus melihat pola K-Poppers tersebut di Twitter. Kata Kunci: Gerakan Sosial, K-Poppers, Twitter, Fandom, Aktivisme Internet
PATOFISIOLOGI GEJALA PENYAKIT THALASEMIA BETA: A NARRATIVE REVIEW
Authors:   Faculty of Medicine, Universitas Indonesia, Suryoadji Kemal Akbar , Alfian Irvan Muhammad ,   Faculty of Medicine, Universitas Indonesia
Published: May 2022

Thalasemia beta adalah kondisi terjadinya mutasi dari gen beta-globin yang diwariskan dan menyebabkan berkurangnya sintesis rantai beta-globin hemoglobin. Prevalensi thalasemia beta di Indonesia mencapai 3% dari penduduk yang merupakan salah satu tertinggi dari seluruh negara di asia tenggara. Patofisiologi thalasemia beta perlu diketahui sebagai proses terjadiya gejala yang timbul dan agar dapat mengidentifikasikan pasien yang datang dengan suspek thalasemia beta. Tinjauan pustaka terkait patofisiologi berbagai gejala thalasemia beta dibuat berdasarkan temuan dari berbagai jurnal internasional yang terpercaya dan terbaru. Kondisi thalasemia beta menyebabkan adanya pemecahan dari eritrosit yang dihasilkan akibat berkurangnya rantai globin beta dan terdapat rantai globin alpha yang bebas. Kondisi pecahnya eritrosit selanjutnya menyebabkan meningkatnya kerja limpa, meningkatnya jumlah besi yang menyebabkan kelebihan besi, heme yang keluar dari eritrosit juga berubah menjadi bilirubin sehingga berlebih, dan juga terjadi hematopoiesis ekstramedular. Berbagai proses tersebut selanjutnya menyebabkan gejala-gejala pada thalasemia beta seperti splenomegali, facies cooley, anemia, ikterus, dan hepatomegali. Tiga proses yang mendasari patofisiologi pada gejala thalasemia adalah kompensasi terbentuknya sel darah merah yang tidak sempurna, berlebihnya deposit zat besi di berbagai organ, dan hematopoiesis ekstramedular. Proses tersebut dapat menjadi dasar pemahaman dari berbagai manifestasi klinik baik pada anamnesis dan pemeriksaan fisik yang muncul pada pasien thalasemia beta. Kata kunci: gejala, patofisiologi, thalassemia beta
ANALISIS SENTIMEN MASYARAKAT INDONESIA TERHADAP PELAKSANAAN VAKSIN COVID'19
Authors:   Prodi Statistika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Indonesia, Febriyanti Syintya , Nursidah Dea Ratu ,   Prodi Statistika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Indonesia, Gustiara Dela ,   Prodi Statistika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Indonesia, Yulianti Rika ,   Prodi Statistika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Indonesia
Published: May 2022

Adanya pandemi Covid’19 di Indonesia memberikan dampak besar ke berbagai sektor kehidupan. Hal ini menyebabkan pemerintah memberikan respon cepat untuk mengatasi kasus ini dengan pembuatan berbagai kebijakan, salah satunya adalah kebijakan baru mengenai vaksinasi yang diwajibkan untuk semua masyarakat di Indonesia. Kebijakan tersebut menimbulkan berbagai macam respon dari masyarakat yang kebanyakan disalurkan melalui media sosial. Adanya respon dari masyarakat tersebut dapat menjadi salah satu acuan untuk melakukan evaluasi terhadap pelaksanaan vaksinasi di Indonesia. Maka dari itu, dengan memanfaatkan data dari media sosial twitter, penelitian ini bertujuan untuk menganalisis respon masyarakat terhadap pelaksanaan vaksinasi dengan cara mengklasifikasikan respon tersebut ke dalam respon positif, negatif, dan netral. Hasil analisis diperoleh bahwa respon masyarakat selama 3 bulan, yaitu pada bulan Mei dan Juni masih terdapat respon netral sedangkan pada bulan Juli keseluruhan kata memiliki respon negatif seiring dengan kenaikan kasus Covid’19. Kata Kunci: covid’19, vaksinasi, pelaksanaan vaksin, kartu/sertifikat vaksin, sentimen analisis
PERAN REGULASI EMOSI DAN PEMAAFAN SEBAGAI SOLUSI TERHADAP PERILAKU CYBERBULLYING DI KALANGAN REMAJA INDONESIA
Authors: Nugraha Erico Pratama
Published: May 2022

Perkembangan teknologi komunikasi memiliki dampak positif dan negatif, salah satu dampak negatifnya adalah perilaku perundungan siber di kalangan remaja Indonesia. Maka dari itu, penelitian ini bertujuan untuk medeskripsikan terkait solusi yang dapat dilakukan untuk mengurangi perilaku perundungan siber tersebut yang mana penelitian ini menawarkan solusi berupa regulasi emosi dan pemaafan. Metode penelitian yang digunakan adalah studi kepustakaan atau library research dengan teknik analisis data deskriptif. Hasil penelitian ini menunjukan bahwa regulasi emosi dan pemaafan terbukti dapat mengurangi perilaku perundungan siber dengan mencegah, memprediksi, dan menghentikan terjadinya perilaku perundungan siber di kalangan remaja. Berdasarkan hasil pembahasan dan analisis data, dapat disimpulkan bahwa regulasi emosi dan pemaafan dapat dijadikan solusi untuk menghentikan perilaku perundungan siber di kalangnya remaja Indonesia.

Kata kunci: regulasi emosi, pemaafan, perundungan siber
IMPLEMENTASI SIKAP TAWAKAL MENURUT PSIKOLOGI ISLAM DALAM MENGHADAPI PANDEMI COVID-19
Authors: Ayu Winda Kusuma , Azhar Zulfa Aziza , Putri Tiara Eka
Published: May 2022

Pandemi COVID-19 terjadi sejak 2019 hingga saat ini. Hal ini mengakibatkan perubahan di seluruh aspek kehidupan, aspek kesehatan, psikologis, ekonomi, pendidikan dan masih banyak lagi. Banyak korban jiwa akibat terinfeksi COVID-19 sehingga dilakukanlah upaya penanggulangan COVID-19 dengan menerapkan 5M dan pemberian vaksin. Namun, upaya tersebut tidak menutup kemungkinan bagi seseorang untuk tidak terinfeksi COVID-19. Bagi umat Islam, perlu menyikapinya dengan tawakal karena tugas manusia adalah berusaha dan hasilnya ditentukan oleh Allah swt. Tawakal menjadikan hidup lebih tenang dan kuat menjalani cobaan kehidupan. Tujuan narrative review ini adalah untuk mengetahui konsep tawakal dalam Psikologi Islam dan pengaplikasiannya dalam menghadapi pandemi COVID-19.
Kata kunci: Tawakal, Psikologi Islam, Implementasi, Pandemi COVID-19
INTEGRASI KONSEP RELIGIUSITAS ISLAM DENGAN TEKNIK RESTRUKTURISASI KOGNITIF UNTUK MENGATASI KECEMASAN
Authors: Ardiansyah Faisal , Rozi Pahru , Al Fitri Lili Lailatul
Published: May 2022

Latar Belakang: Gangguan kecemasan merupakan gangguan mental yang paling umum ditemukan di dunia dan memiliki dampak besar terhadap penyakit global. Gangguan ini semakin banyak dialami seiring dengan modernitas kehidupan. Maka dari itu, penelitian ini bertujuan untuk mengintegrasikan teknik restrukturisasi kognitif dan aspek religiusitas Islam dalam mengatasi kecemasan. Metode: Metode penelitian ini menggunakan studi pustaka (literature review) dengan teknik analisis deskriptif. Hasil: Teknik-teknik restrukturisasi kognitif dapat diintegrasikan dengan konsep religiusitas Islam berdasarkan hadits Jibril, yaitu Iman, Islam, dan Ihsan. Teknik terdiri dari tahapan identification, normalization, distancing, dan decatastrophizing. Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa dalam mengatasi anxiety, teknik restrukturisasi kognitif dapat diintegrasikan dengan konsep religiusitas Islam.
Kata kunci: Restrukturisasi Kognitif, Religiusitas Islam, Kecemasan
Türkiye’de Sağlık Bilişimi Gelişiminin Akademik Açıdan İncelenmesi
Authors: ATİLLA Edibe Asuman , SEYHAN Fırat
Published: May 2022

Yapılan bu çalışmada, sağlık sektöründe yaşanmakta olan gelişmelere paralel olarak, sağlık bilişiminin gelişimi akademik olarak ele alınmış ve Türkiye’de sağlık bilişimi konusunda verilen ön lisans, yüksek lisans ve doktora düzeyindeki eğitimler, hazırlanmış olan tezler, kitaplar, düzenlenmiş kongre, zirve ve fuarlar ve sağlık bilişimi dergileri incelenmiştir. Yapılan araştırma sonucunda; üniversitelerde sağlık bilişimi alanında eğitim veren 19 ön lisans programı, 23 yüksek lisans programı ile 10 doktora programının olduğu tespit edilmiştir. Sağlık bilişimi alanında hazırlanmış olan tezler incelendiğinde; ilki 2002 yılında yayımlanmış olan 67 yüksek lisans tezi ve ilki 2003 yılında yayımlanmış olan, biri tıpta uzmanlık tezi olmak üzere, toplam 20 doktora tezi hazırlandığı tespit edilmiştir. Sağlık bilişimi alanında yayımlanmış kitap sayısı ise 26’dır. Ülkemizde sağlık bilişimi alanında kongreler de düzenlenmektedir. Uluslararası Sağlıkta Bilişim ve Bilgi Güvenliği Kongresi 2016-2021 yılları arasında beş kez gerçekleştirilmiş olup, Ulusal Tıp Bilişimi Kongresi ise 2001- 2021 yılları arasında 13 kez gerçekleştirilmiştir. Ayrıca ülkemizde Sağlık Bilişimi Yönetimi Derneği, Tıp Bilişimi Derneği, Sağlıkta Bilişim ve Teknoloji Derneği olmak üzere üç farklı dernek faaliyet göstermekte ve sağlık bilişimi ile ilişkili olarak yayın yapan bir adet de dergi bulunmaktadır. Elde edilen sonuçlar doğrultusunda, ülkemizde sağlık bilişimi alanında eğitim sunan kurumların ve bu konuda düzenlenen bilimsel etkinliklerin sayısının arttırılmasının gerektiği önerilmektedir.
Ödeyici Kurum Bakış Açısıyla İleri Evre Böbrek Kanserinde Kaynak Kullanımı: Eğitim ve Araştırma Hastanesi Örneği
Authors: DEMİR Hüseyin , YALÇIN BALÇIK Pınar
Published: May 2022

Çalışmanın amacı, ileri evre böbrek kanseri hastalığını sağlık ekonomisi bağlamında değerlendirmek, hastalığa ilişkin kaynak kullanımını ödeyici kurum bakış açısıyla araştırmaktır. Çalışma tanımlayıcı tipte kesitsel bir araştırma olup araştırmanın evreni 2611 hastadan oluşmaktadır. Veri; hizmet, ilaç ve malzeme olmak üzere üç kategoride değerlendirilmiştir. Analizler bütün hastalara ilişkin veriler kullanılarak yürütülmüştür. Veri analizinde R programı kullanılmıştır. Bulgulara göre, hastaların %52,7’si (1376 hasta) nefrektomi operasyonu geçirmiştir. İEBK hastalığında hizmet, ilaç ve malzemeler yoğun bir biçimde kullanılmaktadır. Hizmet ve malzemeler oldukça yoğun kullanılmalarına karşın bu kaynaklara ilişkin maliyetlerin bir kısmının, ilaç kullanımına ilişkin maliyetlerin ise neredeyse tamamının ödeyici kurum tarafından karşılandığı anlaşılmıştır. Dolayısıyla ilaç kullanımı ödeyici kurum üzerinde zorlayıcı bir etkiye sahiptir. Diğer yandan, hizmet sunumunda kullanılan kaynaklar için ödenen tutarların sürekli olarak artış gösterdiği saptanmıştır. Bu trend, ödeyici kurum bütçesi üzerindeki yükün fazla olduğunu ve bu yükün git gide artabileceğini göstermektedir. Sonuç olarak, hastalığın tedavisi ilaç-yoğun karaktere sahiptir. Bu bulgu, özellikle kemoterapi ilaçları ile sağlanan sağlık sonuçlarının ölçülmesi gerektiğine ilişkin ihtiyacı ortaya koymaktadır.
Calculated Hematological Indices as Predictors of Cardiovascular Complications in Noncardiac Surgery (Pilot Study)
Authors: Sokolov D. D. , Kagramanyan M. A. , Kozlov I. A.
Published: May 2022

The objective: to study the prognostic significance of the ratio of the absolute number of neutrophils to lymphocytes (NLR) and platelets to lymphocytes (PLR) in assessing the risk of cardiovascular complications in non-cardiac surgical interventions.Subjects and Methods. 85 patients aged 66 [61‒70] years who underwent elective vascular surgery were examined.Results. Concomitant circulatory diseases were diagnosed in 98.8%. PLR < 91.2 with the sensitivity of 60% and the specificity of 67.8% was associated with diabetes mellitus (AUC – 0.686; 95% CI 0.576‒0.783, p = 0.0022). Cardiovascular complications were registered in 9.3% of patients. NLR was an independent predictor of cardiovascular complications: OR – 5.216; 95% CI 1.246‒21.826, p = 0.005. NLR > 2.1 discriminated cardiovascular complications with the sensitivity of 75% and specificity of 75% (AUC – 0.827; 95% CI 0.690–0.921; p = 0.004). PLR was also a predictor of cardiovascular complications: OR – 1.0111; 95% CI 1.0001–1.0223; p = 0.027. PLR > 105.5 allowed identifying patients with NT-proBNP > 650 pg/ml with the sensitivity of 75.0% and the specificity of 61.8% (AUC – 0.740; 95% CI 0.630‒0.832; p = 0.0308).Conclusion. NLR and PLR can be used to identify patients with increased cardiac risk when undergoing vascular surgery. Further research in this field is advisable.
Assessment of the Budesonid Protective Effects in Patients with Cardio-Respiratory Comorbidity During Coronary Bypassing with Artificial Circulation
Authors: Sergeev E. A. , Geltser B. I. , Kotelnikov V. N. , Tarasov A. E. , Velichkin V. Yu. , Silaev A. A.
Published: May 2022

The objective: evaluation of the effect of budesonide and low-volume mechanical ventilation (LVMV) on pulmonary volemia, oxygen transport and respiratory biomechanics in patients with concurrent ischemic heart disease (IHD) and chronic obstructive pulmonary disease (COPD) during coronary artery bypass grafting (CABG) with artificial circulation (AC).Subjects and Methods. 50 patients with concurrent IHD and COPD were enrolled in the study. During AC, patients of Group I (20 people) received mechanical ventilation with the peak inspiratory pressure of 15 mbar, tidal volume of 3‒4 ml/kg, positive end-expiratory pressure of 5 mbar in combination with inhalation of nebulized budesonide. In Group II (30 people), the similar isolated respiratory support was provided. Pulmonary blood volume, indices of extravascular lung water (EVLW), pulmonary vascular permeability (PVPI), oxygen delivery (DO2I) and consumption (VO2I), oxygen extraction ratio (O2ER), pulmonary shunt fraction (Qs/Qt), oxygenation index were determined. The study consisted of 3 stages: before AC, after its completion and one day after CABG.Results. Before CABG, the EVLW index in all patients exceeded the standard level by 67‒72%. After weaning from AC, it decreased by 23% in Group I and by 8% in Group II. In patients receiving budesonide, PVPI significantly decreased after artificial circulation, while in patients from Group II, it remained unchanged. DO2I and O2ER in all patients were within the reference range, and VO2I was below it with a minimum value in Group II after weaning from AC. In this cohort, the Qs/Qt level was significantly higher, while OI was lower versus patients from Group I. Among patients who received budesonide immediately after AC and 2 hours after it, pulmonary resistance decreased while lung compliance increased. In Group II, those parameters changed oppositely. In Group I, one case of hydrothorax was recorded, and in Group II, 2 patients were diagnosed with polysegmental pneumonia and 2 patients – with pneumothorax. The median duration of mechanical ventilation in the postoperative period made 220 minutes in Group I, and 290 minutes in Group II (p = 0.018).Conclusion. In patients with concurrent IHD and COPD, use of the combination of low-volume mechanical ventilation and inhalation of nebulized budesonide during AC stabilizes the volemic status of the lungs, improves the oxygenating function and respiratory biomechanics in the postperfusion and early postoperative periods of CABG.
The Integral Method for Predicting the Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Authors: Turovets M. I. , Popov A. S. , Ekstrem A. V. , Streltsova A. M. , Vorontsov O. F.
Published: May 2022

The objective: development of a method for determining the individual risk of post-ERCP pancreatitis (PEP) before endoscopic intervention.Subjects and Methods. A prospective observational study of the results of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) was performed in 1,210 patients. The primary end point was the development of PEP. Multiple regression logistic analysis was used to determine the risk of developing PEP.Results. A model of independent variables was determined, which significantly (p = 0.0001) affected the risk of developing PEP. Based on the results of the logistic analysis, regression coefficients were calculated for all significant patient-dependent factors (gender, age, preoperative level of amylasemia and bilirubinemia, and nature of the underlying disease). The risk of PEP decreased in men (by 47.5%), with an increase in the age of patients (for 1 year by 2.3%) and bilirubin (with an increase of 1 μmol/l by 0.3%) but increased with an increase in amylase activity blood serum (by 0.7% for each 1 U/l). A formula has been developed to assess the individual risk of PEP at the stage of preparing a patient for therapeutic ERCP.Conclusion. Analysis of patient-dependent factors makes it possible to reliably determine the risk of developing PEP. It was determined that a female gender, young age (under 40 years old), sphincter of Oddi dysfunction increased the risk of PEP, while a male sex, stenting of the main pancreatic duct, and jaundice reduced this risk. The use of the proposed formula will help predict a significant (p = 0.0001) degree of risk of PEP before performing primary therapeutic ERCP in a particular patient.
Features of Microbiota in Newborns in Critical Condition at Admission to the Intensive Care Unit of a Specialized Hospital
Authors: Aleksandrovich Yu. S. , Ivanov D. O. , Pavlovskaya E. Yu. , Pshenisnov K. V. , Savicheva A. M. , Shalepo K. V. , Akimenko T. I. , Zemlyanoy D. A.
Published: May 2022

Clarification of etiology and identification of infectious agents in critically ill newborns is a very urgent problem of neonatal resuscitation.The objective. To study the characteristics of microbiota in critically ill newborns at admission to the intensive care unit (ICU) of a specialized hospital.Subjects and Methods. 165 critically ill newborns were examined, and bacteriological tests of blood, feces, and saliva were performed.Results. Positive culture results were obtained in 40 (24%) patients. The most frequent causative agent was S. epidermidis (47.5%). The detection rate of E. faecalis amounted to 15%, S. haemolyticus ‒ 15%, C. albicans – 12.5%, and K. pneumoniae ‒ 10%. Microorganisms were isolated from feces in 70% of cases, from the oral cavity in 62.5%, and from blood in 12.5%. E. faecalis was equally frequent at all three sites (5%).Conclusion. In 76% of patients, no neonatal infectious agent was isolated at admission to ICU of a specialized hospital that is most likely associated with the early administration of antibacterial drugs in the first hours of life of the newborn.
Nomogram M Prognostic Value for Major Adverse Cardiac and Cerebral Events after Elective Cardiac Surgery with Cardiopulmonary Bypass
Authors: Berikashvili L. B. , Kuzovlev A. N. , Yadgarov M. Yа. , Kadantseva K. K. , Ozhiganova E. A. , Likhvantsev V. V.
Published: May 2022

The objective: to evaluate the prognostic value of Nomogram M for major adverse cardiac events (MACE) and major adverse cardiac and cerebral events (MACCE) after elective cardiac surgery with cardiopulmonary bypass.Subjects and Methods. This is a retrospective cohort study of the Nomogram M prognostic value for MACE and MACCE after elective cardiac surgery with cardiopulmonary bypass. 158 patients were enrolled in the study. The prognostic value was estimated using ROC-analysis.Results. The frequency of MACE and MACCE during hospitalization made 5.7% (9 of 158 patients) and 6.3% (10 of 158 patients), respectively. AUC Nomogram M for MACE was 0.888 [0.825; 0.950] (p < 0.001). Cut-off value made 12.5 points (sensitivity – 88.89%, specificity – 83.89%). Odd ratio was 41.67 [95% CI 4.98; 348.61] (p < 0.001).AUC Nomogram M for MACCE was 0.893 [0.834; 0.951] (p < 0.001). Cut-off value made 12.5 points (sensitivity – 90.00%, specificity – 84.46%). Odd ratio was 48.91 [95% CI 5.91; 404.78] (p < 0.001)Conclusion. Nomogram M has a good prognostic value for the occurrence of MACE and MACCE after elective cardiac surgery with cardiopulmonary bypass. For MACE sensitivity made 88.89%, and specificity – 83.89%. For MACCE sensitivity was 90.00%, specificity – 84.46%.
Persistent Critical Illness in Newborns
Authors: Golomidov A. V. , Grigoriev E. V. , Moses V. G. , Moses K. B.
Published: May 2022

The problem of persistent critical illness (PCI) in newborns is poorly understood. The epidemiology of this pathological condition in newborns has not been precisely established, however, it is known that PCI is considered a predictor of an unfavorable outcome in any pathology and proceeds more severely then in adults and children. Long-term outcomes of PCI in surviving newborns are associated with subsequent asthenia, cognitive impairment, chronic fatigue syndrome, a high incidence of disability, complex physiological abnormalities, and chronic organ dysfunction from which they rarely recover.Nutritional, respiratory and hemodynamic supports are key components of neonatal PCI therapy. The physiology of a newborn is different from that of an adult patient; therefore, inotropic therapy in this category of patients requires special approaches. In the past few years, in addition to dopamine, dobutamine and adrenaline, newborns have been prescribed milrinone, norepinephrine, vasopressin, and levosimendan as hemodynamic support. The clinical potential of these drugs in neonates is still under evaluation but there is some evidence for their benefits for use in PCI.
Guidelines of the Association of Anesthesiologists-Intensivists, the Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists, the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), and NGO Russian Sepsis Forum "Diagnostics and antimicrobial therapy of the infections caused by multiresistant microorganisms" (update 2022)
Authors: Beloborodov V. B. , Goloschapov O. V. , Gusarov V. G. , Dekhnich А. V. , Zamyatin M. N. , Zubareva N. A. , Zyryanov S. K. , Kamyshova D. A. , Klimko N. N. , Kozlov R. S. , Kulabukhov V. V. , Petrushin M. A. , Polushin Yu. S. , Popov D. A. , Rudnov V. A. , Sidorenko S. V. , Sokolov D. V. , Shlyk I. V. , Edelshtein M. V. , Yakovlev S. V.
Published: May 2022

Strains of microorganisms characterized by resistance to antimicrobial drugs used in medical organizations continue to spread In most regions of the world including Russia. It is clear that it affects both the effectiveness of antimicrobial therapy and tactics and strategy of its use not only in adults patients but also in children. The pandemic of coronavirus infection, in addition, highlighted the growing problems in treatment of invasive mycoses, the dose adjustment of antibiotics during sorption and dialysis therapy methods. These circumstances made it necessary to make adjustments to Guidelines on Diagnostics and Antimicrobial Therapy of Infections Caused by Multiresistant Strains of Microorganisms, which were prepared by a group of leading Russian experts in 2020 [1]. The submitted version of the recommendations was approved on 25.03.2022 at a joint meeting of the working group with representatives of public organizations: Association of Anesthesiologists-Intensivists, the Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists, the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), and NGO Russian Sepsis Forum. These recommendations reflect an interdisciplinary consensus opinion on approaches to the diagnosis and antimicrobial therapy of infections caused by multiresistant microorganisms. They are based on data from publications obtained from randomized trials as well as based on international clinical guidelines with a high degree of evidence.It is rational to use the Guidelines for determining the tactics of empirical and etiotropic therapy of the most severe infections.
COMPARSION OF ANALGESIC EFFICACY OF ULTRASOUND GUIDED PARAVERTEBRAL BLOCK WITH ROPIVACAINE 0.2% WITH/WITHOUT DEXAMETHASONE WITH GENERAL ANAESTHESIA IN MRM
Authors:   Professor., Karhade Seema , Sanjeev Chavan Himani ,   Junior Resident Smt. Kashibai Navale Medical College And General Hospital, Narhe Pune- 411041.
Published: May 2022

Background: Modified radical mastectomy (MRM) may be associated with severe post-operative pain, leading to chronic pain syndrome. We evaluated whether dexamethasone 0.1ml/kg as an adjuvant to ropivacaine improves analgesic efficacy of Paravertebral block (PVB) in MRM . Method: This double-blind, randomised study was conducted on 60 adult females, scheduled for MRM with axillary dissection. They were allotted into two groups â€“ group R( ropivacaine) (n=30) and group D (ropivacaine + dexamethasone) (n=30) . After inducing general anaesthesia , patients were administered ultrasound-guided thoracic PVB at T4 with 20 ml of 0.2% ropivacaine with and without dexamethasone0.1mg/kg , both as a single level injection. Time to first rescue analgesia, number of rescue analgesia required in 24 hrs and any adverse effects were recorded. Quantitative variables were compared using the unpaired t-test between the two groups. Qualitative variables were compared using the Chi-square test . Results: The duration of analgesia (mean Â± Standard deviation [SD]) was significantly longer in the PVB group with dexamethasone (p value- <0.05). Number of rescue analgesic requirement was significantly reduced in dexamethasone group as compare to without dexamethasone.(p value- 0.001) Conculsion:Paravertebral block with ropivacaine and dexamethasone has a longer duration of analgesia than with plain ropivacaine.