bluuebunny/crossref_metadata_2025 huggingface dataset:
Participation of Lens Proteins and miRs in Traumatic and Inheritance
Cataract: A Review on Diagnostic and Therapeutic Approaches for
Cataract Management
Authors: Panda Siva Prasad , Pachauri Navneet , Kesharwani Adarsh , Prasanth DSNBK , Singh Vikrant
Published: June 2024

Traumatic and inherited cataract spiking blindness is caused by accumulated deposition of mutant eye lens protein or lens microarchitecture alteration. A traumatic cataract is a
clouding of the eye’s natural lens that occurs as a result of physical trauma to the eye. This trauma can be caused by various incidents such as blunt force injury, penetration by a foreign object,
or a significant impact on the eye area. Inheritance cataracts or hereditary cataracts are cataracts
that are genetically inherited from one or both parents. Complications following cataract surgery
encompass various adverse outcomes such as inflammation, infection, bleeding, swelling, drooping eyelid, glaucoma, secondary cataracts, and complete loss of vision. The main purpose of the
review is to highlight common pathophysiology associated with traumatic and inherited cataracts. Also, the review discusses diagnosis and treatment strategies for such cataract types by
targeting their key pathological hallmarks. γD-crystallin plays a crucial role in maintaining the
optical properties of the lens during the life span of an individual. Carbamazepine, Resveratrol,
and Myricetin (CRM) are effectively bound at the γD-crystallin binding site and thereby could
minimize misfolding and aggregation of γD-crystallin. miR-202, miR-193b, miR-135a, miR365, and miR-376a had the highest levels of abundance in the aqueous humor of individuals
diagnosed with cataracts. The validation of these miRs will provide more insights into their
functional roles and may be used for diagnostic purposes. The effective CRM combination as a
multidrug formulation may postpone both traumatic and inherited cataracts and protect the eye
from blindness.
Pt(IV) Prodrug Photoactivation: A Promising Strategy for Cancer Therapy
Authors: Tang Lingkai , Luo Yafei , Luo Wenqin , Sun Guangzhou , Jiang Yu , Zhang Zhigang , Yue Xinru , Li Siyao , Liang Li , Liu Wei , Hu Jianping
Published: June 2024

:

Platinum (II) drugs, including cisplatin, carboplatin, and oxaliplatin, have achieved significant
clinical success in cancer treatment. However, their clinical application has been greatly
hindered by various adverse factors, such as non-specific activation and drug resistance. Compared
with Pt(II) drugs, the axial ligands within Pt(IV) compounds can improve the pharmacokinetic
properties, selectivity, and biological activity, implementing alternative cytotoxic mechanisms
beyond DNA cross-linking and partially overcoming drug resistance. The controlled conversion
of Pt(IV) prodrugs into Pt(II) agents at the tumor site has been extensively explored internationally.
In this review, Pt(IV) prodrug modification strategies are first summarized, and the development
of the predominant external and internal photosensitizers is listed. Finally, three representative
photoreduction mechanisms and strategies for developing corresponding Pt(IV) prodrugs
are discussed. This work provides constructive instruction for the subsequent molecular design of
Pt(IV) prodrugs.
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future
Authors: Jain Akanksha , Kumar Rajesh , Mothsra Poonam , Sharma Atul Kumar , Singh Anil Kumar , Kumar Yogesh
Published: June 2024

:

Tuberculosis (TB) is one of the leading causes of death world-wide after AIDS. It infects
around one-third of global population and approximately two million people die annually
from this disease because it is a very contagious disease spread by Mycobacterium tuberculosis.
The increasing number of drug-resistant strains and the failure of conventional treatments against
this strain are the challenges of the coming decades. New therapeutic techniques aim to confirm
cure without deterioration, to reduce deaths, contagions and the formation of drug-resistant
strains. A plethora of new diagnostic tests are available to diagnose the active tuberculosis, screen
latent M. tuberculosis infection, and to identify drug-resistant strains of M. tuberculosis. When effective
prevention strategies do not prevail, high rates of early case detection and successive cures
to control TB emergence would not be possible. In this review, we discussed the structural features
of M. tuberculosis, Multi drug resistance tuberculosis (MDR-TB), extremely drug-resistant
tuberculosis (XDR-TB), the mechanism of M. tuberculosis infection, the mode of action of first
and second-line antitubercular drugs, the mechanism of resistance to the existing drugs, compounds
in preclinical and clinical trial and drugs presently available for the treatment of tuberculosis.
Moreover, the new diagnostic techniques to detect M. Tuberculosis are also discussed in this
review.
A Comprehensive View on Narrative Aspects of Cosmeceutical Agents
Intended for Skin Care
Authors: Pal Rashmi Saxena , Pal Yogendra , Chaitanya MVNL , Dogra Sakshi Sharma , Srivasatava Preeti
Published: June 2024

Cosmetics may have "pharmaceutical therapeutic benefits" but not always "biological therapeutic rewards.,” Products for skin care that combine cosmetics and pharmaceuticals are known as
Cosmeceuticals. Cosmeceuticals are applied topically like cosmetics, but they also contain substances
that affect the biological functions of the skin. Cosmetics make people seem better, but they do so by
giving their skin the nutrition it needs to stay healthy. Cosmeceutical skincare has specific ingredients
to correct particular skin concerns or conditions. For example, they have high percentages of salicylic
acid and niacinamide to correct oily to acne-prone skin. A skincare expert has access to pharmaceutical-grade items that can be utilized to customize each client's at-home or face regimen. This study
aims toprovide an up-to-dateanalysis of cutting-edge natural bio-actives that not only improve skin
health but also shield it from a range of dangerous agents, such as UV radiation and free radicals.
Recent Advances in the Transition Metal (Cu, Ni, Fe, Co) Catalyzed OrganicReaction: A Mini-Review
Authors: Kamboj Monika , Yadav Nikita , Bajpai Sangeeta
Published: June 2024

:

Transition metals have a useful and significant role in catalysis. They are considered essential chemical tools in various organic transformations.
Transition Metal catalysts are extensively used in the research laboratory and industrial/manufacturing processes. Indeed, it is hard to find a
complex synthetic reaction or an industrial process that does not, at some stage, require a metal catalyst. They have a paramount impact on organic
transformations and have been considered the core part of catalysis in chemistry. This article reports the catalyst reaction by transition metals (Cu,
Ni, Fe, and Co).
A Review of Traditional Anthelmintic Approaches: Exploring Medicinal Plants and Polyherbal Formulations for Effective and Safe Gastrointestinal Parasite Treatment
Authors: Pannu Arzoo , Kumari Parina
Published: June 2024

:

Gastrointestinal parasites have become the most common reason for infection in humans, affecting many people in the world. Helminthic infections pose a large threat to public
health in developing countries. The most common parasites of helminths in humans are whipworms(Trichuristrichiura), roundworms(Ascarislumbricoides), tapeworms(Taenia solium), and
hookworms (Ancylostoma duodenale and Necator americanus). In the current scenario, synthetic
medicines are found to be effective in curing the infection but these medicines produce side-effects that impair the effectiveness of the treatment. Fortunately, in the traditional system of medicines various medicinal plants have been mentioned for their anthelmintic activities, which are
relatively free from side effects and are used by ethnic groups worldwide. In the 21st century, an
ideal anthelmintic agent should be cost-effective, provide a high percentage of cure, have a broad
spectrum of action, and free from toxicity to the host. However, none of the modern marketed
medicines fulfill these requirements. Therefore, in this view, several researchers have undertaken
various in vivo and in vitro studies to scrutinize folklore medicinal plants for their proclaimed
anthelmintic activity. In thisreview, we have summarized some scientifically approved polyherbal
formulations and Indian medicinal plants documented for anthelmintic activity, which can be further studied to achieve novel herbal lead molecules from them by isolating their principal compounds.
A Developed Model Based on Machine Learning Algorithms for Phishing Website Detection
Authors: Abdel-Jaber Hussein , Al Bazar Hussein , Naser Muawya
Published: June 2024

Introduction:

Users are accessing websites for many purposes, such as obtaining information
about a particular topic, buying items, accessing their accounts, etc. Cybercriminals use
phishing websites to attain the sensitive information of the users, like usernames and passwords,
credit card details, etc. Detecting phishing websites helps in protecting the information and the
money of people. Machine learning algorithms can be applied to detect phishing websites.

Methods:

In this paper, a model based on various machine learning algorithms is developed to
detect phishing websites. The machine learning algorithms used in this model are Decision
Tree, Random Forest, Extra Trees, K-Nearest Neighbors, Multilayer Perceptron and Support
Vector Machine. The dataset of phishing websites is taken from the Kaggle website. The algorithms
mentioned above of the developed model are compared together to identify which
algorithm has better classification results.

Results:

The extra trees algorithm offers the best results for accuracy, precision, and F1-
Score. This paper also compares the developed model with a previous model that uses the
same dataset and relies upon decision tree, random forest, and support vector machine to determine
which model has better classification report results. The developed model, depending
on the Decision Tree and SVM, offers better classification results than those of the previous
models. The developed model is compared with another preceding model relying upon
Decision Tree and Random Forest algorithms to determine which model generates better results
for accuracy, precision, recall/sensitivity, and F1-Score.

Conclusion:

The developed model, depending on the Decision Tree, presents better results
for accuracy, recall, and F1-Score than the results of accuracy, sensitivity, and F1-Score for
the preceding model based on the Decision Tree.
Development and In vitro Evaluation of Pantoprazole-Sustained Release
Effervescent Floating Tablets for Effective Management of Ulcer
Authors: Virgilus Onyishi Ikechuchukwu , Amarachi Chime Salome , Elizabeth Ike-Onyishi Ugochi , Ijeoma Ndukauba , Achile Akpa Paul , Chigozie Ezeudoh Clara , Tochuchukwu Ogbonna Emmanuella
Published: June 2024

Introduction:

Pantoprazole is a very suitable drug for the treatment of numerous
acid-related conditions in humans and mammals. Owing to its short half-life (0.9 – 1.9 h), it is
ideal for sustained release formulation.

Methods:

This study was aimed at developing pantoprazole gastroretentive (GR) controlledrelease tablets and to determine the effects of this formulation and processing parameters on
drug release and other critical quality attributes of directly compressed tablets produced using
different matrix-forming polymers, namely, Hydroxypropyl methylcellulose (HPMC), chitosan, sodium alginate, maize starch, kappa- carrageenan, and propyl vinyl pyrrolidine PVP K30 when formulated into effervescent Floating Drug Delivery Systems (FDDS).

Results:

The buoyancy lag time of less than 5 seconds and a total floating time of more than 12
hours for all batches is a good indication of achieved floatation for FDDS.

Conclusion:

Validation processes initiated with the five batches indicated that the polymer
blends had the potential for the formulation of pantoprazole FDDS and, hence, could enhance
patient compliance and better treatment outcomes due to their sustained release potentials.
Unravelling Phyto-Compound Therapeutics against SRC Protein via FGF
Pathway Targeting-A Comprehensive Approach Integrating Omics Data
Analysis, Network Pharmacology, Virtual Screening, and Molecular
Dynamics
Authors: Tripathi Pankaj Kumar , Jain Chakresh Kumar
Published: June 2024

Introduction:

Colorectal cancer is a complex condition influenced by genetic mutations and environmental factors. Due to its intricate nature, the diagnosis and treatment of this condition require a
comprehensive approach that considers individual circumstances. The study aimed to identify genes
linked with colorectal cancer and their therapeutic agents from natural bioactive compounds.

Methods:

The significantly prognostic differentially expressed genes (DEGs) were screened out
from NCBI Gene Expression Omnibus (GEO) datasets. A protein-protein interaction network was
constructed using STRING Database, and key genes were identified using Network Analyzer and
CytoNCA plugins within Cytoscape. Further analysis involved functional annotations, and biological pathways analysis, SRC mechanism to uncover the role of SRC in CRC. Additionally, we performed virtual screening and molecular docking, Physiochemical property analysis along with MD
simulation study to propose suitable natural compounds for promising therapeutic targets.

Results:

The study conducted differential gene expression analysis, identifying 3621 statistically
significant genes, with 1467 upregulated and 2154 downregulated. The top ten genes with the highest degree, betweenness centrality, and closeness centrality in the PPI network were selected as key
genes. The SRC gene was found to have the highest degree and closeness centrality. Functional annotation and pathway analysis of key genes with a specific focus on the SRC mechanism revealed
that the SRC's role in activating the RAS-RAF-MEK-ERK and Wnt/β-catenin pathways in CRC
cells, promoting proliferation and invasion. Molecular modelling of SRC led to the screening of
phyto-compounds from tropical fruits, with Rutinexhibiting a higher docking score compared to
FDA-approved anticancer drugs. MD simulations over 100 ns and the post-MD analysis i.e. RMSD,
SASA, RMSF, FEL, RG, Hydrogen bond, PCA, and MMPBSA, comprehended the stable and robust interactions of a protein-ligand complex. These findings suggest Rutin's potential as a potent
natural molecule for treating CRC.
The study concludes that SRC plays a pivotal role in CRC, influencing cellular processes critical to
cancer development and Rutin has been found to be a promising SRC inhibitor, suggesting a potential alternative therapeutic strategy for CRC. The consistent molecular interactions of Rutin necessitate further validation through wet lab experiments, offering hope for individuals affected by CRC
Livros brancos, imagens negras: uma abordagem (in)disciplinar
Authors: Guerra Susana
Published: June 2024

This paper aims to contribute with elements for the problematisation, expansion, and improvement of the study of African history textbooks in Brazilian education. Textbooks are often limited by new stereotypes, with images that erase the violence present in interracial relationships. On the other hand, the authorship of these images in textbooks still does not belong, for the most part, to black artists and intellectuals. We propose an approach to the art of Rosana Paulino, with the aim of thinking about how her work: a) incorporates elements that allow us to recognise the presence of black women in the contemporary artistic context; b) calls into question the proliferation of a vision of the world that excludes women; and c) profiles any content of African History from an anti-racist horizon.
The Effect of Combining Foot Exercises and Neuromuscular Taping on Diabetic Foot Neuropathic Pain
Authors: Ilahude Imran , Kristianto Heri , Wibisono Ahmad Hasyim , Blow David
Published: June 2024

Neuropathic pain in diabetic feet can affect patients' quality of life. This has an impact on sleep quality and daily activities. Neuromuscular taping (NMT) intervention and foot exercises can be therapeutic modalities for diabetic feet. A study on the combination of the two is needed. The research aimed to determine the effect of diabetic foot exercises and neuromuscular taping on diabetic foot neuropathic pain. The research employed a quasi-experimental design with a crossover design approach. The sample included 24 people recruited using the purposive sampling method. The sample was divided into two groups: the control group and the intervention group. The control group received foot exercises only, while the intervention group received a combination of foot exercises and neuromuscular taping. The washout period was carried out for one week. Neuropathic pain scores were measured using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS). Data were analyzed using the Wilcoxon test. The study's results showed that the mean change in neuropathic pain scores in the control group with a median (min-max) value was -2.00 (-8 - 0). In the intervention group, the mean change with a median (min-max) value was - 7.50 (-10). - 0). There was a significant reduction of diabetic foot neuropathic pain in the control and intervention groups with a p-value of 0.000 (α<0.05). In conclusion, a combination of foot exercise and neuromuscular taping interventions can be an option for managing diabetic foot neuropathic pain
Chronic inflammatory demyelinating polyneuropathy: current state of the problem (analysis of a clinical case)
Authors: Goncharova Z. A. , Kovaleva N. S.
Published: June 2024

Chronic inflammatory demyelinating polyneuropathy is an acquired autoimmune disease of the peripheral nervous system, heterogeneous in course and clinical manifestations, which is curable. The variety of forms of the disease and its course cause difficulties in timely diagnosis and initiation of pathogenetic therapy. This article presents a clinical observation of a patient with a wide range of concomitant pathologies, the presence of which significantly complicated the diagnosis and led to delayed prescription of immunosuppressive therapy.
Morning clinical conference in a therapeutic hospital: is it needed today?
Authors: Ponomareva E. Yu. , Rebrov A. P. , Nikitina N. M.
Published: June 2024

The article presents the experience of the staff of the Department of Hospital Therapy conducting a morning conference on the clinical basis of therapeutic departments of a multidisciplinary hospital. The role and importance of the morning conference format in the organization of hospital work in several areas of activity are considered. The role of the conference moderator, the specifics of presenting the material in the reports of the doctor on duty, the possibilities of interdisciplinary discussion of various aspects of diagnosis and treatment in this format were discussed in more detail.
Long-term results of endovascular treatment of patients with coronary heart disease using various PCI technologies
Authors: Malevannyy M. V. , Hripun A. V. , Chesnokov V. V.
Published: June 2024

Objective: the effectiveness and safety of endovascular treatment of coronary artery disease in coronary artery disease using various technologies of percutaneous coronary intervention (PCI) was evaluated — implantation of drug-coated metal stents, implantation of bioresorbable stenting scaffolds, the use of drug-coated coronary balloon catheters in the long- term period, 10 years after PCI.

Materials and methods: data obtained from 324 patients with coronary heart disease after PCI using the previously mentioned treatment methods. The endpoint was the loss of the target vessel lumen (TLF), a combination of cardiac death, myocardial infarction, and revascularization associated with the target vessel.

Results: the treatment of patients with coronary heart disease using implantation of drug-coated metal stents, bioresorbable stenting scaffolds or drug-coated coronary balloon catheters is safe and has low rates of cardiac mortality, myocardial infarction and revascularization of the target vessel in the long term. In cases where implantation of stents or scaffolds was contraindicated or impossible due to the small diameter of the artery, diffuse extended lesion and high risk of restenosis, angioplasty with a coronary balloon catheter with an antiproliferative drug coating takes place, showing positive long-term results.
Między filozofią a światopoglądem. Myśl społeczna i religijna Józefa M. Bocheńskiego w kontekście sporów ideowych w XX wieku
Authors: Kroczek Piotr
Published: June 2024

The monograph “Between Philosophy and Worldview: The Social and Religious Thought of Józef M. Bocheński in the Context of Ideological Disputes in the 20th Century” by Piotr Kroczek offers a comprehensive analysis of the intellectual legacy of one of Poland’s most prominent philosophers of the 20th century. The work focuses on the social and religious aspects of Bocheński’s thought, which he developed in the context of the major events and ideological disputes of his era, such as the two World Wars, the rise and spread of communism, and the Second Vatican Council. Kroczek presents Bocheński not only as a theoretician but also as an active participant in these events, providing deeper insight into how his experiences shaped his views. The monograph details how this Dominican used the analytical method to examine issues related to war, peace, democracy, communism, religion, the Catholic Church, clergy, university, economy, law, and justice. Kroczek draws on an extensive source base, including Bocheński’s original texts and numerous studies and commentaries, to thoroughly present and critically assess his thoughts. The author highlights the importance of precision and rigor in Bocheński’s work, particularly his emphasis on logic and linguistic analysis, which were crucial tools for him in seeking truth and debunking superstitions. The monograph also includes comparisons of Bocheński’s thought with other prominent philosophers and an analysis of the impact of his views on contemporary philosophical debates. Kroczek argues that despite the passage of time, many of Bocheński’s reflections remain relevant and can serve as valuable sources of inspiration for addressing contemporary social and philosophical issues. The monograph is not only a tribute to Bocheński’s intellectual heritage but also an invitation for further research into his work. Kroczek underscores the need for a critical approach to Bocheński’s thought, encouraging its creative development and adaptation to modern realities. In conclusion, the monograph “Between Philosophy and Worldview…” is a comprehensive study that portrays Bocheński as a thinker with broad horizons, capable of deep analyses and bold polemics, while also highlighting that his ideas still have much to offer to the contemporary world.
The Impact of Collaborative Documentation on Person-Centered Care: Textual Analysis of Clinical Notes
Authors: Stanhope Victoria , Yoo Nari , Matthews Elizabeth , Baslock Daniel , Hu Yuanyuan
Published: June 2024

Background

Collaborative documentation (CD) is a behavioral health practice involving shared writing of clinic visit notes by providers and consumers. Despite widespread dissemination of CD, research on its effectiveness or impact on person-centered care (PCC) has been limited. Principles of PCC planning, a recovery-based approach to service planning that operationalizes PCC, can inform the measurement of person-centeredness within clinical documentation.

Objective

This study aims to use the clinical informatics approach of natural language processing (NLP) to examine the impact of CD on person-centeredness in clinic visit notes. Using a dictionary-based approach, this study conducts a textual analysis of clinic notes from a community mental health center before and after staff were trained in CD.

Methods

This study used visit notes (n=1981) from 10 providers in a community mental health center 6 months before and after training in CD. LIWC-22 was used to assess all notes using the Linguistic Inquiry and Word Count (LIWC) dictionary, which categorizes over 5000 linguistic and psychological words. Twelve LIWC categories were selected and mapped onto PCC planning principles through the consensus of 3 domain experts. The LIWC-22 contextualizer was used to extract sentence fragments from notes corresponding to LIWC categories. Then, fixed-effects modeling was used to identify differences in notes before and after CD training while accounting for nesting within the provider.

Results

Sentence fragments identified by the contextualizing process illustrated how visit notes demonstrated PCC. The fixed effects analysis found a significant positive shift toward person-centeredness; this was observed in 6 of the selected LIWC categories post CD. Specifically, there was a notable increase in words associated with achievement (β=.774, P<.001), power (β=.831, P<.001), money (β=.204, P<.001), physical health (β=.427, P=.03), while leisure words decreased (β=−.166, P=.002).

Conclusions

By using a dictionary-based approach, the study identified how CD might influence the integration of PCC principles within clinical notes. Although the results were mixed, the findings highlight the potential effectiveness of CD in enhancing person-centeredness in clinic notes. By leveraging NLP techniques, this research illuminated the value of narrative clinical notes in assessing the quality of care in behavioral health contexts. These findings underscore the promise of NLP for quality assurance in health care settings and emphasize the need for refining algorithms to more accurately measure PCC.
Implementasi KMK 722 Tahun 2020 tentang Standar Profesi Penata Anestesi
Authors: Wahyudi Fikri Mourly , Suryanah Agustina , Juarta Tata , Nugraha Indri Lidya
Published: June 2024

Penata anestesi adalah salah satu dari dua jenis tenaga kesehatan yang berwenang melakukan asuhan kepenataan anestesi di Indonesia. Sejak tidak lagi menjadi bagian dari profesi keperawatan, penata anestesi mempunyai peraturan perundangan dan kebijakan kesehatan yang mengatur kompetensi dan kegiatan profesionalnya. Standar profesi sebagai salah satu pedoman dalam melakukan pekerjaan dan menjadi rujukan penyusunan kurikulum pendidikan calon penata anestesi belum pernah dilakukan analisis ketercapaiannya, termasuk pada kompetensi keterampilan klinis. Penelitian ini bertujuan memotret tingkat ketercapaian dan pemenuhan keterampilan klinis penata anestesi di pelayanan. Jawa Barat dipilih sebagai tempat penelitian karena mempunyai jumlah penata anestesi terbanyak di Indonesia, yaitu 641 orang. Penelitian dilakukan dengan metode kuantitatif dan menggunakan pendekatan deskriptif. Pengumpulan data dilakukan menggunakan kuesioner yang pernyataannya mengacu pada Standar Profesi Penata Anestesi yang diatur dalam KMK 722 Tahun 2020. Sampel dipilih secara acak dengan metode simple random sampling dan diperoleh 112 responden. Data yang terkumpul dianalisis dengan mencari nilai minimal, maksimal, dan mean. Hasil penelitian menunjukan bahwa seluruh kompetensi dalam keterampilan klinis penata anestesi pernah dilakukan dengan derajat yang beragam. Adapun kegiatan yang paling jarang dilakukan adalah tindakan yang menyangkut metodologi asuhan dan penatalaksanaan resusitasi pada situasi emergensi dan bencana. Sehingga diperlukan pelatihan dan pendidikan yang lebih mendalam mengenai metodologi asuhan dan penatalaksanaan gawat darurat. Sementara kegiatan yang bersifat limpah wewenang dari dokter anestesi sering dan hampir selalu dilakukan penata anestesi. Hal ini menunjukan tingkat kepercayaan profesional diantara keduanya. Guna mempertahankan dan meningkatkan hubungan tersebut, diperlukan pelatihan dan pendidikan lebih jauh mengenai Interprofessional Education.
Systematic Literature Review: Faktor yang Berhubungan dengan Kepatuhan Peserta PBPU dalam Membayar Iuran JKN
Authors: Tsuroyya Sabrina Luthfi , Maharani Chatila
Published: June 2024

Tingkat kolektibilitas peserta Jaminan Kesehatan Nasional (JKN) yang rendah disebabkan karena rendahnya tingkat kepatuhan dalam membayar iuran. Segmen Peserta Bukan Penerima Upah (PBPU) menunggak iuran paling banyak dibandingkan dengan segmen lain yaitu sebesar Rp5,65 triliun (86,88%). Tinjauan sistematis ini bertujuan untuk meninjau secara sistematis faktor-faktor yang berhubungan dengan kepatuhan peserta PBPU dalam membayar iuran JKN di Indonesia. Metode penelitian adalah systematic literature review yang bersumber dari database PubMed, Google Scholar, dan GARUDA dengan rentang waktu dari tahun 2014-2022. Pencarian dan seleksi artikel dilakukan dengan berpedoman pada protokol PRISMA. Protokol penelitian ini telah terdaftar pada PROSPERO (CRD42022378124). Dari 13 artikel yang dianalisis didapatkan faktor-faktor yang berhubungan dengan kepatuhan peserta PBPU dalam membayar iuran JKN meliputi faktor pendapatan, persepsi, motivasi, pendidikan, pengetahuan, usia, jumlah keluarga, pekerjaan, manfaat program, jarak dan waktu tempuh ke tempat pembayaran. BPJS Kesehatan diharapkan dapat terus berinovasi pada sistem pembayaran dalam program JKN agar memudahkan peserta dalam membayar iuran serta rutin melakukan sosialisasi terkait program JKN secara menyeluruh.
Assessing Job Satisfaction of Community Pharmacists with the Warr-Cook-Wall Instrument in West Java
Authors: Kusumah Wardani Sintaresmi , Yasin Nanang Munif , Trung Vo Quang
Published: June 2024

Background: Improving the quality of public health cannot be separated from the role of pharmacists who are responsible for providing pharmaceutical services. Pharmacists' long working hours and great responsibility impact how satisfied they feel with their jobs.Objectives: This study  aims to determine the level of job satisfaction and identify the variables that affect community pharmacists' job satisfaction in West Java.Methods: A cross-sectional study conducted in mid-December 2022 to mid-February 2023 with research subjects community pharmacists working in pharmacies, primary health centers or clinics in the West Java region. A convenience sampling technique was used for selecting a community pharmacist. This study involved 145 community pharmacists and used a semi-structured questionnaire, Warr-Cook-Wall satisfaction scale and implemented the Likert scale to describe pharmacists’ job satisfaction of community pharmacists in West Java. The analysis used is univariate analysis (descriptive and distribution analysis) and bivariate analysis (multiple regression linear analysis).Results: Most community pharmacists in West Java are more satisfied with the variables in the intrinsic factor (3.0±0.66) than extrinsic factors (3.0±0.70). However, their satisfaction is still low on recognition (2.9±0.7) and income (2.7±0.8). Community pharmacists' job satisfaction is influenced by pharmacy ownership type (p=0.04) and working hour (p=0.05). The regression analysis indicates that working hour had negatively influenced job satisfaction.Conclusion: Community pharmacists feel satisfied with their job, and their satisfaction level is affected by pharmacy working hours.
Analisis Kinerja Sistem Pemantauan Berbasis Streaming Telemetry gNMI dengan Simulasi Jaringan Containerlab
Authors: Fierda Kurniacahya Ariefputra  , Eueung Mulyana
Published: June 2024

Pesatnya pertumbuhan internet berdampak pada perkembangan layanan digital. Lonjakan permintaan ini telah menciptakan peluang bagi pelaku industri layanan digital. Meskipun memiliki dampak positif, pertumbuhan internet juga menimbulkan tantangan teknis. Dalam konteks mengatasi pertumbuhan lalu lintas data, pemantauan sumber daya (resource) menjadi salah satu faktor yang krusial. Salah satu cara terbaru untuk memantau sumber daya tersebut adalah dengan menggunakan sistem streaming telemetry Google Remote Procedure Call (gRPC) Network Management Interface (gNMI). Meski tampak lebih superior dari protokol yang telah ada, studi lebih lanjut dalam pengimplementasian sistem streaming telemetry perlu dikaji. Makalah ini difokuskan untuk menginvestigasi trade-off dan kinerja streaming telemetry gNMI. Perancangan dan simulasi dilakukan menggunakan networking lab tools berbasis Docker, yaitu containerlab. Integrasi sistem pemantauan dan topologi jaringan juga dilakukan dalam simulasi berbasis Docker tersebut. Hasil pengamatan dari tiap protokol menunjukkan bahwa aktivitas mengambil metrik oleh sistem pemantauan tidak berpengaruh signifikan terhadap kondisi jaringan. Hal tersebut ditunjukkan oleh rata-rata latency jaringan yang bervariasi rendah dan throughput yang hampir seragam kecuali pada kondisi lossy dan congestion. Pengamatan pada simulasi juga menunjukkan sistem pemantauan gNMI menggunakan sumber daya input/output (I/O) lebih intensif dibandingkan protokol lainnya. Penelitian ini juga membahas tentang integrasi streaming telemetry gNMI dan log monitoring, yang menunjukkan kenaikan penggunaan memori sebesar 70 MB dan sumber daya Disk I/O yang meningkat sebesar 33%. Dalam penelitian ini juga ditemukan indikasi peningkatan penggunaan CPU oleh sistem pemantauan gNMI sebesar 50% dari data modus yang dicatat dalam pengamatan.
Family Planning Practices, Knowledge, Decision Making, and Factors Associated with Unplanned Pregnancies among Women Working in A Selected Garment Industry in Urban Bengaluru, India
Authors: Hombaiah Chandana
Published: June 2024

Background: According to UN population estimates, India has surpassed China as the world’s most populated nation, marking the biggest upheaval in global demography since records have been kept. Providing universal family planning services is an important strategy to reduce maternal morbidity and to control population growth. Even though the country has multiple programs addressing family planning issues, they are missing out on working women. Thus, this study aims to estimate the prevalence of unmet needs of family planning and determinants for improper access to family planning methods among women working in a selected Garment industry in Urban Bengaluru. Methodology: A community based cross-sectional study was conducted in a selected garment factory for a period of two months. Women workers in Reproductive age group (18-49 years) and who gave voluntary consent to participate in the study were taken up. Total sample of 454 women were included. The data was collected using a semi-structured and validated questionnaire. Collected data was entered in Microsoft Excel and was analysed using SPSS version 16. Results: Among 454 participants, 42.3% (n=192) of them had used contraceptive method. Out of 192 women, most of them (72.9%, n=140) had chosen tubectomy as the contraceptive measure. Among 407 women, 14.3% (n=58), 13.3% (n=42), and 20.9% (n=9) of them had not planned for their 1st pregnancy, 2nd pregnancy, and 3rd pregnancy respectively. Conclusion: Less than half of them had used any form of contraceptive method. Among that half, nearly three-fourths had chosen tubectomy.
SANAT SOSYOLOJİSİ BAĞLAMINDA SON DÖNEM TÜRK RESİM SANATI
Authors: Akbaş Arif
Published: June 2024

Sanat sosyolojisi, sanat ve estetiğin toplumsal boyutlarını araştıran bir sosyoloji alt alanıdır. Bu makalede sanat sosyolojisi bağlamında Türk resim sanatı yorumlanıp değerlendirilecektir. Tarih boyunca sanat sosyolojisini incelemek, sanatın sosyal tarihini, çeşitli toplumların belirli sanatçıların ortaya çıkmasına nasıl katkıda bulunduğunu incelemektir. Sanat sosyolojisi, sanatın toplumsal işleyişindeki sorunları ve sanat ile toplum arasındaki çeşitli etkileşim biçimlerini inceleyen bir sosyoloji dalıdır. Bu disiplin içinde iki ana yön vardır: Ampirik ve teorik. Teorik sanat sosyolojisi, sanat ve toplum arasındaki ilişki biçimlerini, sosyal grupların ve devlet kurumlarının sanatsal yaratıcılığın gelişimindeki eğilimler üzerindeki etkisini ve sanatçılığın kriterlerini belirlemekle ilgilenir. Ampirik sanat sosyolojisi izleyicileri, onların sanat algısını inceler ve sanatsal yaratıcılık süreçlerinin ve algısının niceliksel bir analizini yapar. Biz burada daha çok nesnel ve yorumlayıcı yaklaşım (verstehende) kapsamında Türk resim sanatını sosyolojik yönden analizini/ çözümlemesini yapacağız. Bu alana benzer disiplinler: Sanat psikolojisi, sanat tarihi ve sanat felsefesidir. Modern sanat sosyolojisi kurumsal bir nitelik kazanmıştır. Tüm dünyada bölümler ve araştırma merkezleri açılmaya başlanmış ve sosyolojinin bu alanına yönelik bilimsel dergiler yayımlanmıştır.
Evolution of agricultural machinery parts restoration industry in Russia
Authors: Lyalyakin V. P.
Published: June 2024

The paper shows the effectiveness of agricultural machinery parts restoration by reducing metal and fuel consumption as well as labor costs. (Research purpose) The paper analyzes the evolution of the machine part restoration system during the agricultural industrialization process in Russia, and explores the role of industrial science in developing methodologies for machine repairing and part restoration. (Materials and methods) Publications on the history of the parts restoration industry were thoroughly reviewed. Special attention was given to the decrees issued by Soviet government bodies, including the targeted comprehensive program of the State Committee of Science and Technology, the USSR State Planning Committee, and the State Committee for Agricultural Technology. These programs were aimed at establishing and expanding the production base for the repair and restoration of agricultural machinery parts. (Results and discussion) In the early stages of agricultural industrialization, equipment repairs primarily involved the use of new spare parts, while worn parts were typically discarded for remelting. A significant advancement in parts restoration was the introduction of repair sizes for crankshafts and cylinder liners. Since 1975, the cost of maintaining equipment has surged sharply due to the prices of new spare parts. The paper also presents an analysis of the efforts by the All-Union Scientific and Production Association «Remdetal» to develop flow-mechanized lines and equipment for restoring agricultural machinery parts. (Conclusions) The paper illustrates the significant growth in parts restoration volumes, rising from 68 million rubles in 1965 to 539 million rubles in 1988, as well as metal savings that increased from 136 thousand tons to 1,110 thousand tons over the same period. Additionally it highlights the role of the USSR Academy of Sciences, leading scientific institutes, and machine-building enterprises in executing the targeted program to increase the restoration volumes of agricultural machinery parts and components.
Identification of an ellipse and a sub-ellipse of errors by elements of the covariance matrix
Authors: Gordeev V.A. , Shevshenko G.G.
Published: June 2024

The authors present a study of the point position mistake relationship with the elements of the error ellipse. The comparison of the mentioned error, determined by the F. R. Helmert’s and P. Werkmeister’s formulas, is given. It is shown that they both are related to the elements of the error ellipse and the covariance matrix of the coordinate vector. For the conditions of the polar serif, the dependence of the correlation coefficient of the determined point coordinates on the directional angle of the line to this point, as well as that of the angular and linear measurements mutual accuracy, is established. The relationships between the elements of the covariance matrix and those of the ellipse of point position errors are investigated for various special cases. Namely, when the correlation coefficient is zero, it is ± 1, in the case of equality of the determined point’s inverse weight matrix diagonal elements and when the determination of the point’s position was performed by a polar serif. The error ellipse dimension is considered as a function of linear COEX systems in all directions. Its graphs and subtypes are presented depending on the determined point’s inverse weight matrix elements values
Coordinate georeferencing of geoimages using computer vision
Authors: Mukhametshin A.R. , Samsonov T.E. , Lurie I.K.
Published: June 2024

This paper presents the process of creating a model for automated georeferencing of geo- images using image matching technology, an increasingly popular computer vision concept that has not received proper attention in cartography to date. LoFTR (Local Feature Matching with Transformers), a new approach to find and match key points in pairs of images was used as a basis for the developed model. At the first stage, a model architecture and successive stages of input data processing were defined. At the second stage, the model was implemented as a program in accordance with the previously outlined steps. At the third stage, the resulting model was tested on several pairs of geoimages to further evaluate its effectiveness and applicability in various scientific tasks. Results show that the developed model provides a universal algorithm for automated georeferencing of geo-images, demonstrating high-quality results
Evaluation of Dosimetric and Radiobiological Parameters for Different TPS Dose Calculation Algorithms and Plans for Lung Cancer Radiotherapy
Authors: Çağlan Ayça , Dirican Bahar
Published: June 2024

Lung cancer presents a major public health concern in our country and around the globe. Radiotherapy is one of the main treatment modalities for lung cancer management for several years. This study aims to evaluate differences in the dosimetric and radiobiological parameters and in the dose distributions of Planning Target Volume (PTV) and organs at risk (OAR) in patients with lung tumors using different Treatment Planning System (TPS) algorithms and Volumetric Modulated Arc Therapy (VMAT) technique. This study was accomplished in a group of 19 patients with lung tumors who were treated in our clinic. In the treatment planning of the patients; Elekta-Monaco  with Monte Carlo (XVMC), Pencil Beam algorithm; Varian-Eclipse with Anisotropic Analytical Algorithm (AAA), Acuros XB (AXB)algorithms and Tomo-plan Treatment Planning System with Convolution Superposition algorithm of Tomotherapy device were used. In these treatment planning systems, plans were done by 6 MV photon energy using Volumetric Arc Therapy (VMAT) techniques. The prescribed dose to the PTV was 60 Gy in 30 fractions. Statistical analysis was performed using SPSS Statistics v.29.0.2.0 programme. Statistically, significant differences were found in Dmean, Dmax, D2 and D98 values for PTV between the algorithms, while small differences were found in Dmax values of the contralateral lung, total lung and esophagus in critical organs. It is concluded that the difference between algorithms for PTV increases especially as the volume of the target tumor decreases. TPS with C/S algorithm gave closer results with XVMC. Algorithms were found to have an impact on radiobiological parameters.
Effective Atomic Numbers of Glass Samples
Authors: Karpuz Nurdan
Published: June 2024

Effective atomic numbers are a term used to understand the interaction of a compound or material with radiation. In particular, this term is often used for materials with complex structures that can be expressed by a single fixed atomic number.
If different elements in a material are present in different concentrations, the effective atomic number of the material can be calculated by considering the contribution of each element. This is a useful method to better understand the response of the material to radiation or the effect of radiation within the material. In particular, when radiation passes through or acts on the material, the effective atomic number plays an important role in determining factors such as the material's radiation exposure properties, absorption or scattering.
Effective atomic numbers are used in radiation interaction analyses in various fields such as materials science, medicine, geophysics and industry. This concept is used to express in a simpler way the radiation properties of compounds in which different elements are combined.
In this study, the effective atomic numbers of magnesium borosilicate glasses were investigated. Such studies are important in the field of materials science and glass technology because the chemical constituents of glass and their interactions play a decisive role in the properties of glass.
Magnesium borosilicate glasses are often used in industrial applications. The properties of these glasses depend on the amount of elements they contain and their chemical structure. Effective atomic numbers can be used to understand the specific properties of a material.
By determining the effective atomic numbers of the elements contained in the glass, this study aims to provide an important basis for understanding the properties of the material, such as radiation exposure, electrical properties or optical properties.
UMA ANÁLISE DA LITERATURA SOBRE A IMPLEMENTAÇÃO DAS TECNOLOGIAS E METODOLOGIAS DE ENSINO DA EDUCAÇÃO 4.0 EM ESCOLAS BRASILEIRAS COM O USO DO PROTOCOLO PRISMA
Authors: Ribeiro Rafaela Corrêa , Xavier Marcelle Caruzo , Silva Claudio Aprigio da , Violante Flávio de Almeida , Castro Denise Leal de , Santos Genildo Nonato
Published: June 2024

Em um mundo cada vez mais dependente de tecnologia, adequações em diversos setores da sociedade sempre são necessárias para acompanhar essas evoluções. De maneira semelhante, a educação tenta seguir essa mesma tendência adequando currículos e métodos às necessidades atuais. O movimento conhecido como Educação 4.0 é a materialização da necessidade de implementação de adequações tecnológicas no currículo das escolas do século XXI. Dessa forma, é altamente relevante tentar entender como está ocorrendo o movimento Educação 4.0 nas escolas nacionais. Assim, o objetivo do presente estudo é o de investigar, na literatura, propostas e estudos de caso que nos permitam entender o cenário atual sobre a implementação da educação 4.0 no Brasil, mais especificamente o da infraestrutura tecnológica e de metodologias de ensino. Para esta finalidade utilizamos o protocolo PRISMA a fim de realizar uma seleção guiada de artigos de interesse e a lógica CIMO para a realização da análise sistemática. Nossa análise mostra haver movimentos pontuais, motivados pela força de vontade de alguns professores e pesquisadores, mas que enfrentam diversos tipos de desafios, como por exemplo falta de infraestrutura tecnológica, de metodologias padronizadas entre outras. Nossa conclusão evidencia que as escolas em território nacional necessitam de apoio para que seja implementada a Educação 4.0, em termos de infraestrutura tecnológica e metodologias padronizadas. Entretanto, devido à escassez de relatos publicados na literatura, é possível apenas afirmar que o presente estudo carece de outros relatos, além dos que foram utilizados, para se tornar mais robusto.