bluuebunny/crossref_metadata_2025 huggingface dataset:
CIMENTO PBS®CIMMO EM PREENCHIMENTO DE FALHAS ÓSSEAS: ESTUDO EXPERIMENTAL EM RATOS: PARTE II
Authors: Zerbinati Christiano Cândido , Neto José Dias da Silva , Veiga Daniela Francescato , Schnaider Taylor Brandão
Published: January 2022

As extrações dentárias originam falhas ósseas, alvéolos frescos. Condições clínicas que exigem abordagem com instalação de implantes e reabilitação estética através de próteses sobre os implantes. Este procedimento reabilitador chama-se carga imediata e a condição para que seja possível ser realizada é a estabilidade primária dos implantes. Objetivo: Avaliar cimento PBS®CIMMO no preenchimento de falhas ósseas. Métodos: Trinta e seis ratos Wistar adultos machos foram organizados em três Grupos de doze indivíduos cada (Grupo 1, Grupo 2 e Grupo 3). Aprovação CEUA parecer 265/17. Em todos os Grupos realizou-se uma falha óssea no fêmur com as dimensões de 2,0 mm de largura por 7,0 mm de profundidade. No Grupo 1, aplicou-se o cimento PBS®CIMMO na falha óssea produzida e instalouse implante de titânio (CONEXÃO®) medindo 1,5mm de espessura e 6mm de comprimento na cavidade. No Grupo 2, aplicou-se o cimento PBS®CIMMO na cavidade. No Grupo 3 realizou-se apenas a falha óssea. Resultados: Realizou-se os testes de Kruskal Wallis para cada área e comparou-se a média dos três Grupos. Foi aplicado o teste Dunn que comparou a média de cada Grupo entre si: Grupo 1 com Grupo 2, Grupo 1 com Grupo 3 e Grupo 2 com Grupo 3. Em todas as comparações ocorreu significância para o Grupo 2 p = 0,0014. Conclusão: O cimento PBS®CIMMO induziu neoformação óssea e observou-se integração osso neoformado, cimento e parafuso de titânio.
COMORBIDADES PSIQUIÁTRICAS EM EPILEPSIA
Authors: Bragatti José Augusto
Published: January 2022

A associação entre epilepsia e transtornos psiquiátricos tem sido descrita desde o início da prática da Neurologia e da Psiquiatria, com vários exemplos na literatura. Hipócrates, por volta do ano 400 AC, observou uma dicotomia entre epilepsia e melancolia, propondo que estas entidades estariam ligadas por um provável mecanismo fisiopatológico comum (MAGUIRE, in press). A história da interface entre epilepsia e psiquiatria teve seu início marcado pela associação empírica destas condições com deuses, bruxas, demônios e fenômenos sobrenaturais. Os gregos referiam-se à epilepsia como a “doença sagrada”. Nesta época, Hipócrates supôs que o ataque de fúria que motivou Hércules a matar seus filhos tinha uma origem epiléptica. Os romanos referiam-se à epilepsia como “morbidus lunaticus”, relacionando-a com as diferentes fases da lua. No mundo árabe, a associação entre epilepsia, doença mental e demônios persistiu, e profetas como Maomé e São Paulo, que, dizia-se, periodicamente ouviam vozes e caíam ao solo, supostamente sofriam de epilepsia (REYNOLDS e KINNIER-WILSON, 2008). Nos séculos XIX e início do XX, epilepsia era um diagnóstico comum em asilos de pacientes com doença mental. Os pacientes mais graves eram tratados por psiquiatras, enquanto os menos graves permaneciam na comunidade, onde eram tratados por clínicos gerais ou por neurologistas (NADKARNI et al., 2007). As observações de Emil Kraepelin, na década de 1920, são consideradas a base da classificação diagnóstica psiquiátrica moderna. Kraepelin descreveu precisamente as alterações afetivas dos pacientes com epilepsia antes da era da terapia anticonvulsivante. Episódios disfóricos, caracterizados por irritabilidade, com ou sem ataques de fúria, segundo ele, representavam o transtorno psiquiátrico mais comum da epilepsia. Depressão, ansiedade, cefaleia e insônia frequentemente completavam o quadro clínico, enquanto humor eufórico era menos comum (BLUMER, 2008). Mais recentemente, a introdução de técnicas avançadas de neuroimagem, como a tomografia por emissão de positrons (PET), a ressonância magnética funcional do encéfalo acoplada ao EEG (EEG/RMf), e a espectroscopia, combinadas a modelos animais e testes comportamentais refinados, tornou possível a identificação de mecanismos fisiopatológicos comuns às epilepsias (principalmente a do lobo temporal) e transtornos psiquiátricos, sobretudo a depressão maior (BRAGATTI, 2021).
ANÁLISE HIDRODINÂMICA DOS CAMPOS DE ENERGIA DAS ONDAS GERADAS PELO VENTO NO RESERVATÓRIO DE TUCURUÍ
Authors: Marques Marcelo , Valdivia Alejandro Victor Hidalgo , Andrade Fernando Oliveira de , Arantes Elaine Patricia , Ferreira Isabela Arantes
Published: January 2022

A simulação da distribuição espacial da energia das ondas geradas pela ação de ventos severos sobre o reservatório de Tucuruí constitui-se no objetivo deste trabalho. Os campos de energia das ondas foram simulados com base em na combinação de uma equação paramétrica denominada JONSWAP e da equação de energia fundamentada no conhecimento de mecânica das ondas. Pela técnica empregada denominada Modelagem Paramétrica Bidimensional (MPB), a energia da onda é condicionada exclusivamente por informações de vento (intensidade e direção) e o comprimento do fetch no ponto de interesse. A técnica de modelagem foi aplicada pelo modelo computacional ONDACAD. As maiores quantidades de energia de onda resultaram de ventos provenientes das direções W e WNW, de energia correspondente a 656 J/m2 (U=5ms-1); 2624 J/m2 (U=10ms-1); 5904 J/m2 (U=15ms-1); 10496 J/m2 (U=20ms-1).
SIMULAÇÃO NUMÉRICA DOS CAMPOS DE ONDAS GERADAS POR VENTOS SEVEROS NO RESERVATÓRIO DE JURUMIRIM
Authors: Marques Marcelo , Andrade Fernando Oliveira de , Arantes Elaine Patricia , Okawa Cristhiane Michiko Passos
Published: January 2022

A simulação da distribuição espacial das ondas geradas pela ação de ventos severos sobre o reservatório da barragem de Jurumirim se constitui no objetivo desse trabalho. Por situarem-se próximos à divisa com o Estado do Paraná, os ventos severos foram estimados através da análise de frequência regional de dados provenientes das estações anemométricas do Instituto Meteorológico do Paraná (SIMEPAR). A análise considerou os registros horários das rajadas medidas nas estações do SIMEPAR para o período de 1998 a 2005. Os testes estatísticos produziram estimativas de ventos severos que variaram entre 14,6 ms-1 (período de retorno de 10 anos) a 27,6 ms-1 (período de retorno de 100 anos). As alturas de ondas foram simuladas com base em uma equação paramétrica concebida especificamente para esse reservatório pela aplicação da técnica de modelagem Paramétrica Bidimensional. Por essa técnica, a altura da onda é condicionada exclusivamente por informações de vento (intensidade e direção) e o comprimento do fetch no ponto de interesse. A técnica de modelagem foi aplicada pelo modelo computacional ONDACAD. As maiores alturas de onda resultaram de ventos severos provenientes da direção WNW, produzindo ondas de alturas correspondentes a 1,16m (Tr=10 anos), 1,41m (Tr=20 anos), 1,97m (Tr=50 anos) e 2,67m (Tr=100 anos).
CARACTERIZAÇÃO E SORÇÃO DE FÓSFORO NOS SEDIMENTOS DO RIO CORRENTE DOS MATÕES, PIAUÍ
Authors: Araújo Fernanda Benício Coelho de , Moura Marcio Cleto Soares de , Santos Gláucia Viana dos
Published: January 2022

Este trabalho teve como propósito avaliar as concentrações de fósforo e nitrogênio nos sedimentos nas épocas seca e chuvosa e os parâmetros de adsorção de fósforo do rio Corrente dos Matões na região hidrográfica do Parnaíba/PI. A amostragem dos sedimentos foi realizada em nove pontos da microbacia, nos meses de setembro de 2013 (período seco) e fevereiro de 2014 (período chuvoso), compreendendo nascentes, segmentos intermediários e foz. Nos sedimentos foi realizada a granulometria e medidas as concentrações das frações de fósforo (fósforo total, fósforo inorgânico total, fósforo orgânico total) e nitrogênio total, além da determinação dos parâmetros de adsorção de fósforo. O período de amostragem (período seco) e a baixa capacidade de diluição do rio e algumas atividades antrópicas (fontes de poluição difusas) contribuíram para o aumento nas concentrações de fósforo e nitrogênio total em sedimentos do rio. Além disso, os parâmetros de adsorção de fósforo, através das isotermas de Langmuir e Freundlic, apresentaram o comportamento da adsorção de fósforo que foram maiores na região intermediária do rio, podendo estar associada às características dos sedimentos.
DESENVOLVIMENTO DE INTERFACE WEB PARA PUBLICAÇÃO DE ROTAS DE ÔNIBUS QUE TRAFEGAM ENTRE AS IES EM UMA CIDADE DO PARANÁ USANDO LOD
Authors: Santos Matheus Minski dos , Ribas Milena Bastos , Souza Lucélia de , Michelon Gisane Aparecida , Dall´Agnol Josiane Michalak Hauagge
Published: January 2022

A Web Semântica possibilita a adição de significado aos dados que foram ou estão sendo gerados, de forma que eles sejam facilmente compreendidos por máquinas e seres humanos, permitindo analisar dados que antes seriam complexos ou impossíveis de serem analisados. Esse trabalho tem o objetivo de abranger os estágios da semantificação de dados, desde a coleta dos dados até sua publicação na Web, conforme a metodologia proposta para dados abertos conectados pelo Grupo LaSED da Universidade Estadual do Centro-Oeste (Unicentro). O resultado é apresentado por meio do desenvolvimento de uma interface Web que possibilita a geração de consultas semânticas referentes às rotas urbanas de linhas de ônibus que percorrem as Instituições de Ensino Superior da cidade de Guarapuava, Paraná.
Glucose oxidase as a model enzyme for antidiabetic activity evaluation of medicinal plants: In vitro and in silico evidence
Authors: Ashande Colette , Masunda Adrien , Ngbolua Koto-te-Nyiwa , Kilembe Jason Thambwe , Matondo Aristote , Liyongo Clément Inkoto , Benjamin Gbolo Zoawe , Emmanuel Lengbiye Moke , Tshibangu Damien S.T. , Tshilanda Dorothée D. , Mpiana Pius T. , Mudogo Virima
Published: January 2022

Diabetes mellitus is a major public health problem in the world. In Africa, more than 80% of patients use plants for their treatment. However, the methods of validation of endogenous knowledge usually used are costly. The alternative method developed in this study aims at creating hyperglycemia in vitro and exploiting the metabolic pathway involving glucose oxidase for UV-visible spectrophotometric screening of medicinal plants’ antidiabetic activity. The evolution of glucose oxidation as a function of drug concentration is followed by UV-visible spectrophotometry. The formation of the stable complex between the enzyme and the inhibitor is studied using molecular docking. Drugs used (Gliben) and plant extracts exhibited an in vitro hypoglycemic effect by reducing exponentially, in vitro, the level of free glucose. The results also showed that L. multiflora is more active than V. amygdalina (IC50: 1.36 ± 0.09 mg/mL Vs IC50: 3.00 ± 0.54 mg/mL). Gliben (0.5 mg/mL) and L. multiflora (2 mg/mL) reduced both the rate of oxidation of glucose by glucose oxidase (catalytic power Vmax: 0.84 ± 0.11 mg*mL-1*min-1 for Gliben and 1.72 ± 0.13 mg*mL-1*min-1 for L. multiflora); and the affinity of this enzyme for its substrate-glucose (KM: 15.11 ± 2.72 mg*mL-1 for Gliben and 9.17 ± 1.56 mg*mL-1 for L. multiflora) when these results are compared to enzyme catalysis in the absence of inhibitor (Vmax: 2.86 ± 0.44 mg*mL-1*min-1; KM: 8.07 ± 1.96 mg*mL-1). The binding of GOX (1GAL) to selected phytocompounds derived from L. multiflora was confirmed by molecular docking. The most stable complexes were obtained for four compounds; 8 (-10.1±0.0 Kcal/mol), 6 (-9.5±0.1 Kcal/mol), 3 (-8.3±0.0 Kcal/mol) and 9 (-8.2±0.1 Kcal/mol). Among these, compounds 8 and 6 formed complexes with the enzyme stabilized by hydrogen bonds, the compound 8 forms 5 hydrogen bonds (ASN514, ASP424, ARG95, TYP68, LEU65) while compound 6 forms 2 hydrogen bonds (ASN514 and SER422). However, no H-bonding interaction occurs in the complex that involves ligands 9 and 3 despite their high binding energy (-8.2±0.1 Kcal/mol and -8.3±0.0 Kcal/mol respectively). Glucose oxidase can serve as a marker enzyme for in vitro antidiabetic activity evaluation of medicinal plants.
Phytochemical compounds of Guibourtia ehie and their antioxidant, urease and α-glucosidase inhibitory activities
Authors: Bongmo Laurent Voufack Lefack , Nouga Achille Bissoue , Happi Gervais Mouthé , Tabekoueng George Bellier , Lateef Mehreen , Kamdem Waﬀo Alain François , Shaiq Ali Muhammad , Iqbal Choudhary Muhammad , Duplex Wansi Jean
Published: January 2022

Thirteen compounds (1‒13) were isolated and identified during phytochemical analysis of the leaves and stem bark of Guibourtia ehie (A. Chev) J. Leonard. Spectroscopic and spectrometric methods and the comparison of their results with those given in the literature were used to ascertain their structures. Furthermore, the acetylation of 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (2) afforded a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a). Extracts, fractions, and isolated compounds were assessed for their antioxidant, urease, and α-glucosidase inhibitory activities. Compound 1 demonstrated potent antioxidant activity in the DPPH with an IC50 value of 36.4 ± 0.2 µM, while rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively. The present study enriches the chemistry of Guiboutia ehie and provides further evidence on its bioactive constituents, which might help in the development of hypoglycaemic drugs.
ԿԱՅՈՒՆ ԶԲՈՍԱՇՐՋՈՒԹՅԱՆ ԶԱՐԳԱՑՄԱՆ ՈՒՂԻՆԵՐԸ ՀՀ-ՈՒՄ/ THE WAYS OF SUSTAINABLE TOURISM DEVELOPMENT IN THE REPUBLIC OF ARMENIA/ПУТИ РАЗВИТИЯ УСТОЙЧИВОГО ТУРИЗМА В РА
Authors: Tovmasyan Gayane
Published: January 2022

The necessity of sustainable development of tourism is a primary issue in the whole world. With the development of tourism, its negative effects on environment, economy and social-cultural conditions continue to grow. The purpose of the article is to analyze the trends of tourism development in the world and in Armenia, to outline positive and negative impacts of tourism, to assess the possibilities of sustainable tourism development in Armenia. SWOT analysis of sustainable tourism development in Armenia has been carried out in the article, and as a result, some suggestions has been made. In addition, an integrated model has been processed which unites the goals, outputs, main stakeholders and necessary actions of sustainable tourism.
FORMULATION AND EVALUATION OF THYROID HORMONE (T4) IMMEDIATE RELEASE TABLETS
Authors: P Madhivardhana , A N Rajalakshmi , S Padmapriya
Published: January 2022

The aim of this research work is to formulate and evaluate Levothroxine sodium immediate release tablets prepared by direct compression method . Five formulations were evaluated for different pre and post compression parameter and in vitro drug release studies.The results of pre compression parameters of formluation 1 to 5 were compared with prescribed limits. It showed that formulation 1 to 5 powder blend exhibit good flow property and compressibility property. The disintegration time of all formulation was found to be in the range 2mins 09 secsto 4mins 03 secs.Thus, based on evaluation of different parameters it was concluded that formulation of immediate release tablet Levothyroxine sodium was successfully done and F-5 showed almost 93% drug release at 45 mins in Alkaline borate buffer( pH 10). Keywords: Thyroid hormone (T4), Immediate release tablets, Direct compression, Dissolution.
IDENTIFIKASI NEMATODA USUS SOIL TRANSMITTED HELMINTH PADA ANAK-ANAK DI KECAMATAN BARANTI KABUPATEN SIDENRENG RAPPANG
Authors: Islamiati Dian , Basarang Mujahidah , Rianto Muh. Rifo , Widyanti Tuty
Published: January 2022

Soil Transmitted Helminth atau nematoda usus adalah kelompok parasit cacing usus yang memerlukan media tanah yang basah dan lembab untuk perkembangannya. Kelompok soil transmitted helminth (STH) yakni cacing gelang (Ascaris lumbricoides), cacing cambuk (Trichuris trichiura), cacing tambang (Necator americanus dan Ancylostoma duodenale) dan cacing benang (Strongyloides stercoralis). Dilihat dari kondisi lingkungan Kecamatan Baranti terdapat penggunanaan jamban yang tidak layak dan peletakan penampungan air limbah sembarangan mengakibatkan kontaminasi pada tanah yang menjadi tempat berkembangnya nematoda usus. Pengabdian ini bertujuan untuk mengidentifikasi soil transmitted helminth pada feses anak-anak di Kecamatan Baranti Kabupaten Sidenreng Rappang. Jenis pengabdian ini adalah observasi laboratorik. Sebanyak 10 sampel feses dengan menggunakan metode sedimentasi (sentrifugasi). Berdasarkan hasil pengabdian yang telah dilakukakan ditemukan 2 sampel yang positif mengandung telur cacing. Berdasarkan hasil pengabdian dapat disimpulkan bahwa ditemukan soil transmitted helminth pada anak-anak dengan jenis telur cacing Ascaris lumbricoides dan Trichuris trichiura.
Edukasi K3 Dalam Penggunaan Pestisida dan APD Di Kel. Gantarang Keke, Kabupaten Bantaeng
Authors: Rustiah Waode , Rasyid Nur Qadri
Published: January 2022

Pesticides is chemical substances and other materials as well as microorganisms and viruses that are used to control various plant-disturbing organisms. Early public education about pesticides is an important element to avoid increasing exposure for farmers or workers in the spraying division of plant pests. In addition, the community has never carried out early detection and feels that they are already immune and are used to the pungent smell of pesticides. This service activity is carried out with the aim of implementing a community-based education program that facilitates the community in increasing knowledge about early detection and preventive efforts against the using of pesticides that do not meet the requirements in the application of Occupational Health and Safety (K3) principles in Gantarang Keke Village, Bantaeng Regency. Methods of implementation this community service consists of two stages, namely: 1) the preparation stage includes health counseling with the lecture method to the community of Gantarang Keke Village; 2) the implementation stage includes the implementation of the implementation program in the form of implementing K3 correctly and safely. The results show that with education carried out through counseling about the application of K3 to the people of Gantarang Keke Village, they begin to understand about the safe and correct using of pesticides, as well as the use of Personal Protective Equipment in accordance with the requirements in K3 principles.
Penyuluhan Tentang Demam Berdarah (DBD) dan Tanaman Pengusir Nyamuk Di Lingkungan Kecamatan Manggala Kota Makassar
Authors: Muawanah Muawanah , Mu'tamirah Siti , Widyanti Tuty
Published: January 2022

Manggala District is one of the sub-districts in Makassar City which often faces cases of Dengue Fever. Dengue fever is a disease transmitted through the bite of the Aedes aegypti mosquito. The breeding of Aedes Aegypti is increasing due to the increasingly crowded conditions of buildings and housing. These mosquitoes not only live in dirty water environments, but also in clean water such as bathtubs, water reservoirs, and others. Some community members still have limited knowledge and understanding of effective ways of dealing with dengue cases, as well as the use of plant species that can be used to repel mosquitoes. The purpose of the service is to increase the knowledge and understanding of the community about dengue fever and the use of mosquito repellent plants. The extension method is the presentation by the extension team, the discussion stage, and the evaluation stage. The results show an increase in public knowledge and understanding of dengue disease and the use of mosquito repellent plants. The conclusion is that the community finally knows the dangers of dengue disease and knows the types of mosquito repellent plants.
Pemanfaatan Limbah Minyak Jelantah Menjadi Sabun Padat
Authors: Anita Anita , Muharram Fatmawati , Arisanti Dewi , Rauf Darmaway , Suardi Suardi , Ariyanto Bambang
Published: January 2022

Used cooking oil contains compounds that are carcinogenic which pose a risk to human health. Waste cooking oil is also at risk for areas where used cooking oil is disposed, for example into sewers or into the ground. This can contaminate soil and water, thereby endangering humans or the surrounding environment. Therefore, serious action is needed on the use of used cooking oil waste so that it can be utilized optimally as a staple in the soap processing process. Through community service activities which are one of the implementations of the Tridharma of Politeknik Kesehatan Muhammadiyah Makassar Study Program of Medical Laboratory Technology, then education is carried out in the form of counseling to the taklim assembly team at the Al-Hidayah Perumnas Antang Makassar Mosque regarding the use of used cooking oil into solid laundry soap. From this community service activity, it can be concluded that the knowledge of the taklim team at the Al-Hidayah Mosque in Manggala Village, Manggala District, Makassar City regarding the dangers of used cooking oil waste for health and how to process used cooking oil into solid  soap.
Pembuatan Filter Air Sungai dan Penyediaan Penampungan Air Bersih di Desa Penadaran
Authors: Puspitasari Adelia , Maharani Agnes Oktavi , Pramitasari Ratih , Nugroho Syahiful Yudhi , Umayah Wahyuni Ainuly , Prastiwi Kania Salma Nur , Hibatulla Agil Fahrudi , Hardiningtyas Rani , Deyani Deyani , Iqbal Alif Maulana
Published: January 2022

Penadaran Village is a village in Gubug District, Grobogan Regency, Central Java Province. The dry season makes residents in Penadaran Village experience problems with clean water sources. The purpose of community service is to make filters and provide clean water reservoirs for the residents of Penadaran Village. The implementation methods used are: (1) Conducting Tuntang River Water Quality Test, (2) Designing a scheme for clean water filters and reservoirs, (3) Making clean water filters and reservoirs. The location is in Kedungkakap Hamlet, Penadaran Village. The implementation time is August – October 2021. The results of the implementation of community service, obtained the results of the Tuntang River Water Quality Test, namely, Iron: 0.496 mg/L, COD: 301 mg/L, Chloride: 7.30 mg/L, manganese: 0.502 mg/ L, the river water filter scheme uses a system with 3 settling tanks and 2 mixed bed tubes. The shelter uses a 3300 ml Toren with a tower as high as 3 m from the ground. There are 17 families who have received clean water supply from the new source
Determinan Ekspor Teh Indonesia ke Amerika Serikat
Authors: Tarigan Grasella Olivia , Hidayat M. Syurya , Nurhayani Nurhayani
Published: January 2022

Penelitian ini bertujuan untuk menganalisis pengaruh GDP Amerika Serikat, nilai tukar Rupiah terhadap Dollar AS, Harga teh internasional, dan konsumsi teh perkapita Amerika Serikat terhadap ekspor teh Indonesia ke Amerika Serikat . Data yang digunakan adalah data sekunder dengan rentang waktu 18 tahun  (2000-2017). Data dianalisis menggunakan model regresi linear berganda. Hasil penelitian memperlihatkan bahwa GDP Amerika Serikat, harga teh internasional, dan konsumsi teh perkapita Amerika Serikat berpengaruh signifikan terhadap ekspor teh Indonesia ke Amerika Serikat. Sedangkan kurs Rupiah terhadap Dollar Amerika Serikat tidak berpengaruh terhadap ekspor teh Indonesia ke Amerika Serikat.
DEVELOPMENT AND VALIDATION OF RAPID AND SIMPLE BIOANALYTICAL METHOD FOR DOCETAXEL WITH ONE STEP PROTEIN PRECIPITATION
Authors: Mehendale P. C. , Athawale R. B , Singh K. K. ,   C. U. Shah College of Pharmacy, S. N. D. T Women’s University, Santacruz (West), Mumbai - 400 049, Maharashtra, India
Published: January 2022

A rapid and simple bio-analytical method with one step protein precipitation and extraction using acetonitrile as extraction solvent was developed for docetaxel. The extraction efficiency was 87.81% with satisfactory separation of docetaxel and IS peaks by isocratic elution with C18 column (25 cm X 4.5 mm, 0.5μm), acetonitrile and water (53:47 % V/V) as a mobile phase at ambient temperature and flow rate of 1mL/min. Paclitaxel solution in acetonitrile (10 mcg/ mL) was used as internal standard. The calibration curve was linear over the concentration range 50 – 5000 ng/mL, regression coefficient R2= 0.99936 and slope 0.00034. The limit of quantification and limit of detection were found to be 33 ng/ mL and 100 ng/mL, respectively. Coefficient of variation for within day and between the days was in the range of 10.9 to 14.9 and 12.5 to 15.05, respectively. Accuracy of the method indicated % recovery of 97.92 – 104.24%. Thus, a precise, accurate and robust method was developed and validated as per FDA guidelines.
IN VITRO ANTIOXIDANT AND IN VIVO HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ZIZIPHUS RUGOSA LAM. LEAVES
Authors: Parashar S , Uplanchiwar V. , Gautam R. K. , Goyal S. ,   Vedic Institute of Pharmaceutical Education and Research, Sagar - 470 228, Madhya Pradesh, India
Published: January 2022

Ziziphus rugosa Lam. belongs to the family Rhamnaceae and is found chiefly in deciduous and semi evergreen forest of Western Ghats. The present research was undertaken to establish in vitro antioxidant and in vivo hepatoprotective activity of ethanolic extract of Z.rugosa Lam. leaves. The powdered leaves of Z. rugosa were extracted with ethanol and preliminary phytochemical screening was performed for the presence of various phytoconstituents. DPPH assay and β-glucuronidase inhibition assay were selected for the free radical scavenging activity. For the assessment of hepatoprotective activity, alcohol and CCl4 induced hepatotoxicity model were used. The phytochemical analysis of ethanolic extract showed the presence of alkaloids, saponins and flavonoids. The extract exhibited concentration dependent radical scavenging activity with an IC50 value of 61.88 μg/ml and β –glucoronidase inhibition activity with an IC50 value of 70.61 μg/ml. It was speculated that the Z. rugosa Lam. ethanolic extract shows dosedependent hepatoprotective activity which is equivalent with the standard drug Silymarin. The inhibition of free radicals or free radical scavenging activity is significant in the protection against CCl4 and alcohol induced hepatopathy. Hence, it is likely that the antioxidant activity of ethanolic extract of Z. rugosa Lam. might contribute to the hepatoprotective action.
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TENELIGLIPTINE HYDROBROMIDE HYDRATE (TEN) AND METFORMIN HYDROCHLORIDE (MET) IN TABLET DOSAGE FORM
Authors: Joshi H , Khristi A. ,   Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Dist: Vadodara - 391 760, Gujarat, India
Published: January 2022

A simple, accurate, precise, reproducible and economic method developed and validated for the simultaneous estimation of teneligliptine hydrobromide hydrate (TENE) and metformin hydrochloride (MET HCl) in pharmaceutical dosage form. TENE and MET HCl were estimated on Thermoscientific C18 column using mobile phase 0.01M PDP: methanol (45:55 % v/v) (pH 3.5 adjusted with 5% acetic acid) at flow rate 1.0 mL/min. Detection was carried out at 254 nm. The retention time of teneligliptine hydrobromide hydrate and metformin hydrochloride were 7.77 min and 2.64 min, respectively. The linearity was found to be 4-12 μg/mL and 100-300 μg/mL for TENE and MET HCl respectively. R2 value was found to be 0.998 and 0.995. For the assay method % recovery was found in the range of 98.16 – 101 for TENE and MET HCl. The LOD and LOQ were found to be 0.3527 and 1.0690 for TENE and 0.5077 and 1.538 for MET HCl respectively. Method was validated as per ICH guidelines.
QUANTITATIVE ASSESSMENT OF VASICINE AND VASICINONE IN DIFFERENT MARKETED FORMULATIONS USING HPLC
Authors:   Medicinal Natural Product Research Laboratory, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai - 400 019, Maharashtra, India, Akhade M. S , Laddha K. S
Published: January 2022

The main aim was to study the variation in vasicine and vasicinone concentration in different marketed cough syrups using HPLC with photo-diode array detector. Since the marketed formulations were containing Adhathoda vasica extract of varying amount, the amount of vasicine, which is the main constituent, deviated extensively. Also a complete and effective extraction method for quantitative estimation of vasicine and vasicinone from these formulations has been developed. Subsequently, based on the results, it was concluded that the need arises to standardize these marketed formulations.
DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF SELEGILINE HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES
Authors: Prajapati J. B , Rao H , Shah H ,   Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, Changa - 388 421, Dist. Anand, Ta. Petlad, Gujarat, India
Published: January 2022

The present paper discusses about a simple, precise and validated method for the determination of selegiline loaded solid lipid nanoparticles. The study was carried as per the parameters laid down in ICH guidelines. Maximum wavelength of selegiline in 8:2 methanol: chloroform mixture was selected at 258nm. The method was found to be linear in the range of 200μg/mL to 1000μg/mL with correlation coefficient R2 of 0.994. Method was successfully validating as per ICH guidelines. Moreover, this method was simple, sensitive and easy to apply and can be performed at laboratory scale. Hence, the proposed method can be used for analysis of determination of selegiline loaded solid lipid nanoparticles.
EXPLORATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF ALSTONIA SCHOLARIS BARK IN STZ-INDUCED EARLY DIABETIC NEPHROPATHY MODEL IN RATS
Authors: Bandawane D. D. , Jadhav S. B , Juvekar A. R. ,   PES’s Modern College of Pharmacy, Sector 21, Yamunanagar, Nigdi Pune – 411 044, Maharashtra, India
Published: January 2022

Alstonia scholaris (fam. Apocynaceae) is an indigenous plant used traditionally for the treatment of diabetes and associated complications. However the nephroprotective potential of the plant is not scientifically evaluated. Objective of the present was to investigate renal protective activity of hydroalcoholic extract of A. scholaris bark (HEAS) in streptozotocin (STZ)-induced early diabetic nephropathy in rats and to focus on its possible mechanism of action. Experimental diabetes was induced in Wistar rats using single intraperitoneal injection of streptozotocin (65 mg/kg). Animals were divided in five groups (n=6) and treated with 150 mg/kg and 300 mg/kg HEAS for 4 weeks. At the end of study period, fasting blood glucose, blood urea nitrogen (BUN), serum creatinine, total proteins, serum albumin, serum insulin and glycosylated haemoglobin, superoxide dismutase, catalase, reduced glutathione and MDA in kidney were evaluated. Urine was analyzed for albumin, total proteins and creatinine clearance. Kidney and pancreas were subjected for histopathology. Significant decrease in fasting blood glucose, creatinine, albumin, BUN, total proteins and urinary total proteins was observed. Significant improvement in serum insulin, glycosylated Hb, oxidative stress parameters of kidney including superoxide dismutase, catalase and reduced glutathione has been observed in HEAS treated diabetic rats. Histopathology of kidney and pancreatic tissues showed structural improvement. Present study has revealed that HEAS prevented the progression of diabetic nephropathy in STZ-diabetic rats by improving the disturbed glucose homeostasis and by amelioration of renal oxidative stress.
LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF CELECOXIB: AN IN VITRO AND IN VIVO INVESTIGATION
Authors: Shinde S. V , Nikam S , Raut P , Ghag M. K. ,   Department of Pharmaceutics, STES's, Sinhgad Institute of Pharmacy, Narhe, Pune – 411 041, Maharashtra, India
Published: January 2022

In the present research work, celecoxib (CXB) loaded solid lipid nanoparticles (SLNs) were prepared using the probe sonication method, wherein Glyceryl monostearate and Tween 80 were used as solid lipid and surfactant, respectively. To obtain the statistically optimized batch, 32 factorial design was applied. The optimized batch was characterized physicochemically and evaluated through DSC, SEM and XRD studies. The mean particle size of the optimized batch was found to be 135.41± 0.24 nm with a mean % entrapment efficiency of 80 ± 1.69%. The optimized batch was further lyophilized and dispersed into 1% w/v Carbopol 934P to form a gel. Prepared gel was further evaluated for in vitro drug release, occlusivity, ex vivo permeability, local toxicity, in vivo anti-inflammatory activity and accelerated stability study. The study resulted in stable, safe and prolonged anti-inflammatory activity with quick onset of action. Hence, celecoxib loaded solid lipid nanoparticles can be considered as promising alternative to conventional topical systems.
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC - DIODE ARRAY DETECTOR METHOD FOR SIMULTANEOUS ESTIMATION OF ESCITALOPRAM OXALATE AND FLUPENTIXOL DIHYDROCHLORIDE IN COMBINATION
Authors: Gawande V. V , Chandewar A. V. ,   Department Of Pharmaceutical Chemistry, Pataldhamal Wadhwani College of Pharmacy, Dhamangaon Road, Moha Phata, Yavatmal - 445 001, Maharashtra, India
Published: January 2022

The proposed work involves High Performance Liquid Chromatographic – Diode Array Detector method for estimation of escitalopram oxalate and flupentixol dihydrochloride in combination. The analytes were resolved on Waters C18 Xterra column (50 × 4.6 mm id, particle size 3.5 μm) with mobile phase composition of water (containing 0.2 % triethylamine pH adjusted to 2.5 with orthophosphoric acid): acetonitrile: methanol (62:28:10 % v/v/v). The flow rate kept was 1.0 mL/min opting isocratic mode and eluents were tracked down at 230 nm. The retention times for both the drugs were 1.38±0.21 and 2.98±0.41, respectively. Standard addition method was employed for the analysis of flupentixol dihydrochloride. ICH guidelines were followed to validate the method. The method assured linearity in concentration range of 50-150 μg/mL and 2.5-7.5 μg/mL for ESC and FLU, respectively. The method assured high degree of precision and accuracy. The method was proved to be robust by assessing robustness parameters.
Nasopharyngeal Polyp in a Cat: Clinical Assessment
Authors: Emre Yanar Kerim
Published: January 2022

The case report describes diagnosis and surgical treatment of nasopharyngeal polyp in a 3-months-old mixed breed female cat with sneezing, runny nose, lack of appetite and change of voice Serous tear discharge, mucopurulent nasal discharge and increased sensitivity in trachea were detected at clinical examination of the cat Following inspection of the oral cavity, it was observed that the soft palate was bulged and had a different appearance from the normal anatomical structure Significant alterations were not determined in the haematological, biochemical and radiographic examinations However, nasopharyngeal polyp was determined following the contrast-enhanced computed tomography examination After the polyp was removed by a simple invasive procedure, clinical findings of the cat started to improve as from the second day One month after the operation, the she was completely cured and became healthy In conclusion, nasopharyngeal polyp has to be considered for cats with lack of appetite, sneezing, runny nose and change of voice, and collaboration between oropharyngeal examination and transversal shots of the computed tomography would constitute a reliable approach for a precise diagnosis and preoperative planning for feline nasopharyngeal polyps.
Heat stress in dairy cattle – Some potential health risks associated with the nutritional management of the condition
Authors: Vermunt Jos J
Published: January 2022

Heat stress occurs when animals are exposed to environmental temperatures in excess of 25oC (the upper critical temperature), particularly in combination with high relative humidity or direct sunshine. Prevention is by providing plenty of good-quality drinking water, providing shade (natural or artificial), and using water sprinklers and/or fans. Changes to the diet, i.e., high energy density and low protein, are also beneficial and often implemented. However, there may be some potential risks associated with the nutritional management of heat stress in dairy cattle; i.e., the animals are at increased risk of developing subacute rumen acidosis, with ensuing laminitis/lameness, and displaced abomasum. This paper discusses how increasing the energy density of the diet (i.e., increasing the grain/forage ratio), as part of the nutritional management of heat stress, may put cows at greater risk of the above-mentioned digestive disorders.
Post-Corporal Punishment Challenges Facing Eswatini Primary School Teachers When Disciplining Learners and the Necessary Counselling Services
Authors: Dlamini Ruth N. , Ede Moses Onyemaechi , Okeke Chinedu Ifedi
Published: January 2022

The purpose of this study was to explore post-corporal punishment challenges facing Eswatini primary school teachers when disciplining learners and the necessary counselling services. The research employed embedded research design using 48 primary teachers in the Hhohho region in the Kingdom of Eswatini. A purposive sampling was used to select the most accessible research participants. Instruments used were questionnaires and one-on-one interviews. Sixteen schools were selected. Data was collected and analyzed both quantitative and qualitatively. For analyzing data for questionnaires and observation, descriptive statistics such as frequencies and percentages were used and for analyzing data for interviews, thematic analysis was used. Findings show that teachers are facing challenges regarding learner discipline in post corporal punishment in primary schools. Teachers are confused and afraid of infringing learners’ rights. Given the findings, some notable recommendations were highlighted.
Baernstein’s star-function, maximum modulus points and a problem of Erdős
Authors: Marchenko Ivan I.
Published: January 2022

The paper is devoted to the development of Baernstein's method of \(T^{*}\)-function. We consider the relationship between the number of separated maximum modulus points of a meromorphic function and the \(T^{*}\)-function. The results of Bergweiler, Bock, Edrei, Goldberg, Heins, Ostrovskii, Petrenko, Wiman are generalized. We also give examples showing that the obtained estimates are sharp.
Estudio de los parámetros cinéticos en el secado de la cáscara de tuna (Opuntia ficus indica)
Authors: Castro Arata Daphne H. , Otero Nole Kristy , Llamoca Domínguez Edwin
Published: January 2022

El secado incluye dos procesos fundamentales un proceso de transferencia de calor que permite la evaporación del líquido, y la transferencia de masa que permite la difusión del líquido del alimento. El objetivo consiste en determinar los parámetros cinéticos del secado en la cáscara de tuna mediante una estufa a las temperaturas de 50°C, 65°C y 80°C. La cáscara de tuna fue sometida en una estufa Mermmert para un secado por convección a temperaturas de 50°C, 65°C y 80°C en tiempo de 0 a 340 minutos, las cáscaras de tuna trozadas de 2cm x 2cm con espesor de 0.05cm acondicionados en placas petri. Los valores de difusividad fueron de 4.000x10-5m2/s, 5.300x10-5 m2/s, 4.000x10-5 m2/s a las temperaturas de 50°C, 65°C y 80°C respectivamente obteniendo una energía de activación E= 19.419 KJ/mol para un valor de R2=0.994.
Manajemen Sumber Daya Manusia (SDM) Pendidikan Islam (Studi Kasus di Madrasah Aliyah Negeri 1 Ciamis Jawa Barat)
Authors: Munandar Didih Syakir , Syah Muhibbin , Erihadiana Mohamad
Published: January 2022

Sumber daya manusia merupakan salah satu elemen paling penting di berbagai lembaga ataupun perusahaan agar sebuah lembaga atau perusahaan tersebut dapat berjalan dengan baik. Tanpa adanya sumber daya manusia tersebut atau kualitasnya kurang baik, maka Lembaga atau perusahaan akan sulit untuk berjalan dan beroperasi dengan semestinya meski sumber daya yang lain telah terpenuhi. Untuk itu, diperlukan sebuah cara khusus dalam memberdayakan sumber daya manusia yang ada di Lembaga atau perusahaan tersebut. Upaya pemberdayaan sumber daya manusia guna meningkatkan kinerja Lembaga atau perusahaan secara menyeluruh tersebut dikenal dengan istilah manajemen SDM. Jika diaplikasikan dengan akurat dan bijaksana, manajemen SDM mampu memaksimalkan kinerja sebuah lembaga atau perusahaan sehingga perkembangannya dapat berjalan lebih pesat lagi. Karena perannya yang cukup penting bagi perkembangan lembaga atau perusahaan, memahami tentang manajemen SDM adalah hal yang wajib dilakukan oleh para pemilik lembaga atau perusahaan. Begitu juga di lembaga pendidikan yang di dalamnya terdapat proses pembelajaran terhadap para siswa yang salah satu tujuannya adalah melahirkan dan mewujudkan para generasi bangsa yang berkarakter dan berakhlak mulia. Untuk itu, dalam penelitian ini peneliti akan mendeskripsikan mengenai manajemen pendidik dan tenaga kependidikan yang difokuskan mulai dari proses perencanaan, perekrutan, penempatan dan pengembangan pendidik dan tenaga kependidikan di Madrasah Aliyah Negeri 1 Ciamis Jawa Barat.
MENINGKATKAN KEMAMPUAN KOGNITIF ANAK TENTANG NAMA-NAMA BINATANG TERNAK DALAM DUA BAHASA (INGGRIS-INDONESIA) MELALUI METODE BERNYANYI
Authors: Heni Herlina
Published: January 2022

Kognitif yaitu kemampuan anak dalam mengenal, memahami, mengingat, menyebutkan, menyusun dan mengelompokkan serta membedakan benda sesuai bentuk, warna, ukuran, ciri dan fungsinya. Sedangkan metode bernyanyi merupakan metode pembelajaran yang menggunakan syair-syair atau melantunkan kata/ kalimat yang dinyanyikan. Tujuan penelitian ini yaitu: (1) Mengetahui proses pembelajaran dalam peningkatan kemampuan Kognitif anak tentang nama-nama binatang ternak dalam dua bahasa (Inggris-Indonesia) melalui metode bernyanyi. (2) Mengetahui peningkatan kemampuan kognitif anak tentang nama-nama binatang ternak dalam dua bahasa (Inggris-Indonesia) melalui metode bernyanyi. Metode penelitian yang digunakan adalah metode kualitatif, dengan jenis penelitian studi literatur (Library Reseach). Hasil dari penelitian yang di dapat adalah: Anak mampu mengingat nama-nama binatang ternak dalam dua bahasa 79%, anak dapat melafalkan/ menyebutkan kembali nama-nama binatang ternak dalam dua bahasa dengan fasih 85%, dan anak mampu membedakan dan mengelompokkan nama-nama binatang ternak sesuai ciri dan fungsinya 87% signifikan. Kesimpulan dari penelitian menunjukkan bahwa capaian perkembangan kognitif anak tentang nama-nama bintang ternak dengan dua bahasa dengan menerapkan metode bernyanyi dinyatakan berhasil sesuai harapan. Saran untuk penelitian lebih tingkatkan lagi dalam pencarian sumber dari teori-teori yang relevan supaya dapat dijadikan referensi bagi peneliti lainnya.
MENINGKATKAN KEMAMPUAN MOTORIK KASAR ANAK USIA DINI MELALUI GERAK DAN LAGU “BERNYANYI DENGAN RIANG”
Authors: Alvan Hazhari
Published: January 2022

Pendidikan diperlukan bagai anak usia dini untuk mengembangkan semua aspek perkembangan anak melalui desain pembelajaran yang menyenangkan bagi anak. Pendidikan anak usia dini merupakan pondasi dasar pendidikan, yang memiliki peranan penting dalam mengembangkan kemampuan dasar dan meningkatkan potensi kecerdasan anak yang akan mempengaruhi pendidikan di tingkat selanjutnya. Tujuan penelitian ini adalah untuk mengetahui peningkatkan kemampuan motorik kasar anak usia dini melalui gerak dan lagu “Bernyanyi dengan Riang”. Peneltian ini adalah penelitian kepustakaan ( Library Research), Pengumpulan data peneliti menggunakan paper dan journal ilmiah, skripsi dan buku. Teknik analisis data dengan menggunakan reduksi data, display data, dan menarik kesimpulan. Hasil penelitian yang telah dilakukan oleh peneliti baik jurnal maupun skripsi menunjukan adanya peningkatan kemampuan motorik kasar dengan menggunakan gerak dan lagu, artinya terdapat peningkatan motorik kasar pada anak usia dini dengan menggunakan gerak dan lagu “bernyanyi dengan riang”. Karena dengan gerak dan lagu peserta didik merasa senang dan bahagia serta dapat mengingat pesan moral, pesan agama, dan gerakan-gerakan yang diajarkan.
Pengaruh Perilaku Guru dan Pembelajaran Daring terhadap Prestasi Belajar Akidah Akhlaq
Authors: Mahsunah Emy Sa’adah , Siregar Maragustam
Published: January 2022

The pandemic condition causes the learning process to be diverted into an online system. The teacher's behavior changes in an effort to make adjustments along with the changes in learning. Therefore, the authors are interested in researching teacher behavior and online learning. This study aims to conduct research on the effect of teacher behavior and online learning on Akidah Akhlaq learning achievement in students of SMP Al-Muayyad Surakarta in the academic year 2020/2021.

This research method is a type of quantitative research with the independent variable (X) is teacher behavior and online learning and the dependent variable (Y) is Akidah Akhlaq learning achievement. The population in this study amounted to 134 and a sample of 47% or 64 students.

The results of the questionnaire were analyzed by T-test and F-test, termination coefficient (R-square) and multiple linear regression analysis with the results that all independent variables (X) simultaneously had a positive and significant effect on the dependent variable (Y).
The Early Development of Racial Bias in Infants and Childhood
Authors: Meng Shuxian
Published: January 2022

Psychologists are interested in how humans process faces of their own-race and Other-races, and there are plenty of previous research on this topic. This paper will summarize previous paper about Other-race Effect (ORE), and how do ORE develop racial bias in children. Researchers used Implicit Association Test (IAT) to assess implicit racial bias and found that implicit racial bias are different in different cultures and counties.
Discussing the Inheritance and Evolution of the Patronus Mahakala
Authors: Zhang Le
Published: January 2022

As the only Gelugpa temple in Northwest China and the only Green Tara Dojo in China, Guangren Temple, a Tibetan Buddhism temple in Xi’an, Shaanxi Province, is crucial to the study of Tibetan Buddhism development in the mainland. This paper takes the Patronus Mahakala as the starting point, because it is not only one of the most important Patronus, but also the incarnation of Shiva, one of the most critical gods in Hinduism. The extraction elements from the statues and the establishment of a connection with Tibetan Buddhism will help explore the origin of the external components of the sculptures in Buddhism and Tibetan Buddhism. Furthermore, through clarifying the process of religious transmission and development, the conflict and integration of the inter-sectarian, find the impact and evolution of the shape of Gods.
The Implication of Traditional Chinese Culture in Peking Opera
Authors: Liu Moqiao
Published: January 2022

Beijing Opera, as a national opera, is also a part of Chinese traditional culture, is an important form of traditional Chinese culture. It not only shows the characteristics of Chinese traditional culture, but also contains fine traditional virtues and spiritual thoughts. In order to spread the Chinese culture like Peking Opera from generation to generation and promote its international spread, this paper aims to explore the characteristics and implications of traditional Chinese culture embodied in Peking Opera.
The Opportunities and Limitations of Blended Learning and the Flipped Classroom for Second Language Teaching
Authors: Luo Yibu
Published: January 2022

Over the last decade, many educators have been investigating the pedagogical effectiveness of blended learning and flipped classroom models. In the conventional teaching process, instructors have been playing an essential role in the lecturing process. Conversely, students lead the learning process in the flipped classroom because they must complete tasks with extracurricular materials and classroom collaboration. Likewise, blended learning also asks students to dominate classroom learning procedures, but its communication medium is a mixture of face-to-face and online interaction. This essay evaluates blended learning and the flipped classroom model by evidence of both pros and cons. Lastly, the article concluded that the two new models provide significant reference cases in exploring better practice modes to increase the quality of second language teaching.