bluuebunny/crossref_metadata_2025 huggingface dataset:
Porosity Engineering towards Nitrogen-Rich Carbon Host Enables Ultrahigh Capacity Sulfur Cathode for Room Temperature Potassium–Sulfur Batteries
Authors: Liang Jingzhe , Song Wanqing , Wang Haozhi , Ding Jia , Hu Wenbin
Published: November 2022

Potassium–sulfur batteries (KSBs) are regarded as a promising large-scale energy storage technology, owing to the high theoretical specific capacity and intrinsically low cost. However, the commercialization of KSBs is hampered by the low sulfur utilization and notorious shuttle effect. Herein, we employ a porosity engineering strategy to design nitrogen-rich carbon foam as an efficient sulfur host. The tremendous micropores magnify the chemical interaction between sulfur species and the polar nitrogen functionalities decorated carbon surface, which significantly improve the sulfur utilization and conversion. Meanwhile, the abundant mesopores provide ample spaces, accommodating the large volume changes of sulfur upon reversible potassation. Resultantly, the constructed sulfur cathode delivers an ultrahigh initial reversible capacity of 1470 mAh g−1 (87.76% of theoretical capacity) and a superior rate capacity of 560 mAh g−1 at 2 C. Reaching the K2S phase in potassiation is the essential reason for obtaining the ultrahigh capacity. Nonetheless, systematic kinetics analyses demonstrate that the K2S involved depotassiation deteriorates the charge kinetics. The density functional theory (DFT) calculation revealed that the nitrogen-rich micropore surface facilitated the sulfur reduction for K2S but created a higher energy barrier for the K2S decomposition, which explained the discrepancy in kinetics modification effect produced by the porosity engineering.
Formation of Highly Efficient Perovskite Solar Cells by Applying Li-Doped CuSCN Hole Conductor and Interface Treatment
Authors: Yang In Seok , Park You Jin , Hwang Yujin , Yang Hoi Chang , Kim Jeongho , Lee Wan In
Published: November 2022

Li-doped CuSCN films of various compositions were applied as hole-transporting material (HTM) for mesoscopic perovskite solar cells (PSCs). Those films of ~60 nm thickness, spin-coated on the perovskite layer, exhibit significantly higher crystallinity and hole mobility compared with the pristine CuSCN films. Among them, 0.33% Li-doped CuSCN (Li0.33:CuSCN) shows the best performance as the HTM of mesoscopic PSC. Furthermore, by depositing a slight amount of PCPDTBT over the Li0.33:CuSCN layer, the VOC was increased to 1.075 V, resulting in an average PCE of 20.24% and 20.65% for the champion device. These PCE and VOC values are comparable to those of PSC using spiro-OMETAD (PCE: 20.61%, VOC: 1.089 V). Such a remarkable increase can be attributed to the penetration of the PCPDTBT polymer into the grain boundaries of the Li0.33:CuSCN film, and to the interface with the perovskite layer, leading to the removal of defects on the perovskite surface by paving the non-contacting parts, as well as to the tight interconnection of the Li0.33:CuSCN grains. The PSC device with Li0.33:CuSCN showed a high long-term stability similar to that with bare CuSCN, and the introduction of PCPDTBT onto the perovskite/Li0.33:CuSCN further improved device stability, exhibiting 94% of the initial PCE after 100 days.
High-Power Quantum Cascade Lasers Emitting at 8 μm: Technology and Analysis
Authors: Cherotchenko Evgeniia , Dudelev Vladislav , Mikhailov Dmitry , Savchenko Grigorii , Chistyakov Dmitriy , Losev Sergey , Babichev Andrey , Gladyshev Andrey , Novikov Innokentiy , Lutetskiy Andrey , Veselov Dmitry , Slipchenko Sergey , Denisov Dmitry , Andreev Andrey , Yarotskaya Irina , Podgaetskiy Konstantin , Ladugin Maksim , Marmalyuk Aleksandr , Pikhtin Nikita , Karachinsky Leonid , Kuchinskii Vladimir , Egorov Anton , Sokolovskii Grigorii
Published: November 2022

In this work, we demonstrate the features of a two-stage epitaxial growth technique and show the results of power and efficiency measurements for three different designs of quantum cascade lasers with a record-high peak power in the 8 μm spectral region. The time-resolved QCL spectral study proves that InP-based upper cladding paired with an InP contact layer provides better heat dissipation and allows one to reach better power characteristics in comparison with InGaAs-based contact, even with short pulse pumping.
Coupling Plant Polyphenol Coordination Assembly with Co(OH)2 to Enhance Electrocatalytic Performance towards Oxygen Evolution Reaction
Authors: Song Xue-Zhi , Zhao Yu-Hang , Zhang Fan , Ni Jing-Chang , Zhang Zhou , Tan Zhenquan , Wang Xiao-Feng , Li Yanqiang
Published: November 2022

The oxygen evolution reaction (OER) is kinetically sluggish due to the limitation of the four-electron transfer pathway, so it is imperative to explore advanced catalysts with a superior structure and catalytic output under facile synthetic conditions. In the present work, an easily accessible strategy was proposed to implement the plant-polyphenol-involved coordination assembly on Co(OH)2 nanosheets. A TA-Fe (TA = tannic acid) coordination assembly growing on Co(OH)2 resulted in the heterostructure of Co(OH)2@TA-Fe as an electrocatalyst for OER. It could significantly decrease the overpotential to 297 mV at a current density of 10 mA cm−2. The heterostructure Co(OH)2@TA-Fe also possessed favorable reaction kinetics with a low Tafel slope of 64.8 mV dec−1 and facilitated a charge-transfer ability. The enhanced electrocatalytic performance was further unraveled to be related to the confined growth of the coordination assembly on Co(OH)2 to expose more active sites, the modulated surface properties and their synergistic effect. This study demonstrated a simple and feasible strategy to utilize inexpensive biomass-derived substances as novel modifiers to enhance the performance of energy-conversion electrocatalysis.
Changes in Dietary Intake of Methionine, Folate/Folic Acid and Vitamin B12 and Survival in Postmenopausal Women with Breast Cancer: A Prospective Cohort Study
Authors: Sun Yangbo , Fowke Jay H. , Liang Xiaoyu , Mozhui Khyobeni , Sen Saunak , Bao Wei , Liu Buyun , Snetselaar Linda G. , Wallace Robert B. , Shadyab Aladdin H. , Saquib Nazmus , Cheng Ting-Yuan David , Johnson Karen C.
Published: November 2022

Background: Previous experimental studies showed that limiting methionine in the diet of animals or in cell culture media suppresses mammary cancer cell proliferation or metastasis. However, no previous study has investigated the associations of changes in methionine intake with survival among breast cancer survivors. We aimed to examine the association between changes in dietary intake of methionine, folate/folic acid, and vitamin B12 from before to after diagnosis of breast cancer, and mortality among breast cancer survivors. Methods: We included 1553 postmenopausal women from the Women’s Health Initiative who were diagnosed with invasive breast cancer and completed a food frequency questionnaire both before and after breast cancer diagnosis. Multivariable Cox proportional hazards regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence (CIs) of all-cause and breast cancer mortality associated with changes in methionine intake and changes in folate/folic acid and vitamin B12 intake. Results: Relative to pre-diagnosis, 28% of women decreased methionine intake by ≥20%, 30% of women increased methionine intake by ≥20%, and 42% of women had a relatively stable methionine intake (±19.9%) following breast cancer diagnosis. During a mean 16.1 years of follow up, there were 772 deaths in total, including 195 deaths from breast cancer. Compared to women with relatively stable methionine intake, women with decreased methionine intake had lower risks of all-cause (HR 0.78, 95% CI 0.62–0.97) and breast cancer mortality (HR 0.58, 95% CI 0.37–0.91) in fully adjusted models. In contrast, increased methionine intake or changes in folate/folic acid or vitamin B12 intake were not associated with all-cause or breast cancer mortality. Conclusions: Among breast cancer survivors, decreased methionine intake after breast cancer diagnosis was associated with lower risk of all-cause and breast cancer mortality.
Urinary and Daily Assumption of Polyphenols and Hip-Fracture Risk: Results from the InCHIANTI Study
Authors: Pellegrino Raffaello , Paganelli Roberto , Bandinelli Stefania , Cherubini Antonio , Andrés-Lacueva Cristina , Di Iorio Angelo , Sparvieri Eleonora , Zamora-Ros Raul , Ferrucci Luigi
Published: November 2022

A high polyphenol intake has been associated with higher bone-mineral density. In contrast, we recently demonstrated that the urinary levels of these micronutrients were associated with the long-term accelerated deterioration of the bone. To expand on the health consequences of these findings, we assessed the association between urinary level and dietary intake of polyphenols and the 9-year risk of hip fractures in the InCHIANTI study cohort. The InCHIANTI study enrolled representative samples from two towns in Tuscany, Italy. Baseline data were collected in 1998 and at follow-up visits in 2001, 2004, and 2007. Of the 1453 participants enrolled at baseline, we included 817 participants in this study who were 65 years or older at baseline, donated a 24 hour urine sample, and underwent a quantitative computerized tomography (pQCT) of the tibia. Fracture events were ascertained by self-report over 9 years of follow-up. Thirty-six hip fractures were reported over the 9-year follow-up. The participants who developed a hip fracture were slightly older, more frequently women, had a higher dietary intake of polyphenols, had higher 24-hour urinary polyphenols excretion, and had a lower fat area, muscle density, and cortical volumetric Bone Mineral Density (vBMD) in the pQCT of the tibia. In logistic regression analyses, the baseline urinary excretion of total polyphenols, expressed in mg as a gallic acid equivalent, was associated with a higher risk of developing a hip fracture. Dietary intake of polyphenols was not associated with a differential risk of fracture. In light of our findings, the recommendation of an increase in dietary polyphenols for osteoporosis prevention should be considered with caution.
A Randomized, Controlled Study to Investigate How Bovine Colostrum Fortification of Human Milk Affects Bowel Habits in Preterm Infants (FortiColos Study)
Authors: Kappel Susanne Soendergaard , Sangild Per Torp , Ahnfeldt Agnethe May , Jóhannsdóttir Valdis , Soernsen Line Juul , Bak Lene Boejgaard , Friborg Christel , Möller Sören , Zachariassen Gitte , Aunsholt Lise
Published: November 2022

Background: Human milk does not meet the nutritional needs to support optimal growth of very preterm infants during the first weeks of life. Nutrient fortifiers are therefore added to human milk, though these products are suspected to increase gut dysmotility. The objective was to evaluate whether fortification with bovine colostrum (BC) improves bowel habits compared to a conventional fortifier (CF) in very preterm infants. Methods: In an unblinded, randomized study, 242 preterm infants (26–31 weeks of gestation) were randomized to receive BC (BC, Biofiber Damino, Gesten, Denmark) or CF (FM85 PreNAN, Nestlé, Vevey, Switzerland) as a fortifier. Stools (Amsterdam Stool Scale), bowel gas restlessness, stomach appearance score, volume, and frequency of gastric residuals were recorded before each meal until 35 weeks post-menstrual age. Results: As intake of fortifiers increased, stools became harder in both groups (p < 0.01) though less in BC infants (p < 0.05). The incidence of bowel gas restlessness increased with laxative treatments and days of fortification in both groups (p < 0.01), but laxatives were prescribed later in BC infants (p < 0.01). With advancing age, stomach appearance scores improved, but more so in BC infants (p < 0.01). Conclusions: Although there are limitations, a minimally processed, bioactive milk product such as BC induced similar or slightly improved bowel habits in preterm infants.
Pharmacokinetics and Tissue Distribution of 13C-Labeled Succinic Acid in Mice
Authors: Jung Yonghwan , Song Jin Sook , Ahn Sunjoo
Published: November 2022

Succinic acid is widely used as a food additive, and its effects on sepsis, cancer, ataxia, and obesity were recently reported. Dietary drug exposure studies have been conducted to evaluate the in vivo efficacy of succinic acid, but limited pharmacokinetic information is available. Therefore, this study evaluated the pharmacokinetic profiles and tissue distribution of succinic acid following a single intravenous or oral dose. A surrogate analyte, succinic acid-13C4 (13C4SA), was administrated to distinguish endogenous and exogenous succinic acid. The concentration of 13C4SA was determined by a validated analytical method using mass spectrometry. After a 10 mg/kg intravenous dose, non-compartmental pharmacokinetic analysis in plasma illustrated that the clearance, volume of distribution, and terminal half-life of 13C4SA were 4574.5 mL/h/kg, 520.8 mL/kg, and 0.56 h, respectively. Oral 13C4SA was absorbed and distributed quickly (bioavailability, 1.5%) at a dose of 100 mg/kg. In addition, 13C4SA exposure was the highest in the liver, followed by brown adipose tissue, white adipose tissue, and the kidneys. This is the first report on the pharmacokinetics of succinic acid after a single dose in mice, and these results could provide a foundation for selecting dosing regimens for efficacy studies.
Acute Effects of Beetroot Juice Supplementation on Isometric Muscle Strength, Rate of Torque Development and Isometric Endurance in Young Adult Men and Women: A Randomized, Double-Blind, Controlled Cross-Over Pilot Study
Authors: Poredoš David , Jenko Pražnikar Zala , Kozinc Žiga
Published: November 2022

This study was conducted to investigate the effect of concentrated beetroot juice on isometric strength and knee extensor muscle endurance in healthy adults. We conducted a randomized cross-over, double-blind experiment in which participants (18 healthy, physically active adults, 9 men, 9 women) consumed either concentrated beetroot juice (140 mL) or low-nitrate control supplement 2.5 h before the measurement. Isometric maximum strength (peak torque), explosive strength (isometric rate of torque development), and strength endurance at 50% of peak torque were measured on an isometric dynamometer. The results showed that concentrated beetroot juice had no effect on the maximum voluntary isometric strength and rate of torque development of the knee extensors. The only exception was the maximum rate of torque development, for which a positive influence was demonstrated only in men. As for the endurance of the knee extensors, the supplement had a positive effect in men (endurance time increased from 86.4 ± 46.1 s to 103.4 ± 53.7 s; p = 0.022), but not in women. The absence of effect on maximal voluntary strength is consistent with previous research. One the other hand, improvements in endurance and rate of torque development in men only point to an important aspect of a previously under-researched area of sex-specific responses to nitrate supplementation.
Biotin Enhances Testosterone Production in Mice and Their Testis-Derived Cells
Authors: Shiozawa Kota , Maeda Misato , Ho Hsin-Jung , Katsurai Tomoko , Howlader Md. Zakir Hossain , Horiuchi Kimiko , Sugita Yumi , Ohsaki Yusuke , Agista Afifah Zahra , Goto Tomoko , Komai Michio , Shirakawa Hitoshi
Published: November 2022

Late-onset hypogonadism, a male age-related syndrome characterized by a decline in testosterone production in the testes, is commonly treated with testosterone replacement therapy, which has adverse side effects. Therefore, an alternative treatment is highly sought. Supplementation of a high dosage of biotin, a water-soluble vitamin that functions as a coenzyme for carboxylases involved in carbohydrate, lipid, and amino acid metabolism, has been shown to influence testis functions. However, the involvement of biotin in testis steroidogenesis has not been well clarified. In this study, we examined the effect of biotin on testosterone levels in mice and testis-derived cells. In mice, intraperitoneal treatment with biotin (1.5 mg/kg body weight) enhanced testosterone levels in the serum and testes, without elevating serum levels of pituitary luteinizing hormone. To investigate the mechanism in which biotin increased the testosterone level, mice testis-derived I-10 cells were used. The cells treated with biotin increased testosterone production in a dose- and time-dependent manner. Biotin treatment elevated intracellular cyclic adenosine monophosphate levels via adenylate cyclase activation, followed by the activation of protein kinase A and testosterone production. These results suggest that biotin may have the potential to improve age-related male syndromes associated with declining testosterone production.
The Number of Elementary Fermions and the Electromagnetic Coupling
Authors: De Caro Liberato
Published: November 2022

Electric charges and masses of elementary fermions of the Standard Model and fundamental physical constants (speed of light in vacuum, Planck constant, gravitational constant, vacuum permittivity, electron charge) are related through a simple equation. This new relation links 10 of the free parameters of the Standard Model—the masses of the three charged leptons and six quarks, and the electromagnetic coupling—in a compact formula, leaving strong constraints for allowing further elementary charged fermions beyond the Standard Model’s physics. The formula is not derived by theoretical calculations, but it is based on the empirically measured values of the electric charges and proper masses of the known elementary fermions.
Quantitative Structure–Toxicity Relationship in Bioactive Molecules from a Conceptual DFT Perspective
Authors: Pal Ranita , Patra Shanti Gopal , Chattaraj Pratim Kumar
Published: November 2022

The preclinical drug discovery stage often requires a large amount of costly and time-consuming experiments using huge sets of chemical compounds. In the last few decades, this process has undergone significant improvements by the introduction of quantitative structure-activity relationship (QSAR) modelling that uses a certain percentage of experimental data to predict the biological activity/property of compounds with similar structural skeleton and/or containing a particular functional group(s). The use of machine learning tools along with it has made life even easier for pharmaceutical researchers. Here, we discuss the toxicity of certain sets of bioactive compounds towards Pimephales promelas and Tetrahymena pyriformis in terms of the global conceptual density functional theory (CDFT)-based descriptor, electrophilicity index (ω). We have compared the results with those obtained by using the commonly used hydrophobicity parameter, logP (where P is the n-octanol/water partition coefficient), considering the greater ease of computing the ω descriptor. The Human African trypanosomiasis (HAT) curing activity of 32 pyridyl benzamide derivatives is also studied against Tryphanosoma brucei. In this review article, we summarize these multiple linear regression (MLR)-based QSAR studies in terms of electrophilicity (ω, ω2) and hydrophobicity (logP, (logP)2) parameters.
Flavonoids from Piper Species as Promising Antiprotozoal Agents against Giardia intestinalis: Structure-Activity Relationship and Drug-Likeness Studies
Authors: Ticona Juan C. , Bilbao-Ramos Pablo , Amesty Ángel , Flores Ninoska , Dea-Ayuela M. Auxiliadora , Bazzocchi Isabel L. , Jiménez Ignacio A.
Published: November 2022

Diarrhea diseases caused by the intestinal protozoan parasite Giardia intestinalis are a major global health burden. Moreover, there is an ongoing need for novel anti-Giardia drugs due to drawbacks with currently available treatments. This paper reports on the isolation and structural elucidation of six new flavonoids (1–6), along with twenty-three known ones (7–29) from the Piper species. Their structures were established by spectroscopic and spectrometric techniques. Flavonoids were tested for in vitro antiprotozoal activity against Giardia intestinalis trophozoites. In addition, structure-activity relationship (SAR) and in silico ADME studies were performed to understand the pharmacophore and pharmacokinetic properties of these natural compounds. Eight flavonoids from this series exhibited remarkable activity in the micromolar range. Moreover, compound 4 was identified as having a 40-fold greater antiparasitic effect (IC50 61.0 nM) than the clinical reference drug, metronidazole (IC50 2.5 µM). This antiprotozoal potency was coupled with an excellent selectivity index (SI 233) on murine macrophages and in silico drug-likeness. SAR studies revealed that the substitution patterns, type of functional group, and flavonoid skeleton played an essential role in the activity. These findings highlight flavonoid 4 as a promising candidate to develop new drugs for the treatment of Giardia infections.
pH-Sensitive Targeting of Tumors with Chemotherapy-Laden Nanoparticles: Progress and Challenges
Authors: Imtiyaz Zuha , He Jiaxi , Leng Qixin , Agrawal Atul K. , Mixson A. James
Published: November 2022

Accumulating chemotherapeutic drugs such as doxorubicin within a tumor while limiting the drug dose to normal tissues is a central goal of drug delivery with nanoparticles. Liposomal products such as Doxil® represent one of the marked successes of nanoparticle-based strategies. To replicate this success for cancer treatment, many approaches with nanoparticles are being explored in order to direct and release chemotherapeutic agents to achieve higher accumulation in tumors. A promising approach has been stimulus-based therapy, such as the release of chemotherapeutic agents from the nanoparticles in the acidic environments of the tumor matrix or the tumor endosomes. Upon reaching the acidic environments of the tumor, the particles, which are made up of pH-dependent polymers, become charged and release the entrapped chemotherapy agents. This review discusses recent advances in and prospects for pH-dependent histidine-based nanoparticles that deliver chemotherapeutic agents to tumors. The strategies used by investigators include an array of histidine-containing peptides and polymers which form micelles, mixed micelles, nanovesicles, polyplexes, and coat particles. To date, several promising histidine-based nanoparticles have been demonstrated to produce marked inhibition of tumor growth, but challenges remain for successful outcomes in clinical trials. The lessons learned from these histidine-containing particles will provide insight in the development of improved pH-dependent polymeric delivery systems for chemotherapy.
Modification of the Tumor Microenvironment Enhances Anti-PD-1 Immunotherapy in Metastatic Melanoma
Authors: Shi Guilan , Scott Megan , Mangiamele Cathryn G. , Heller Richard
Published: November 2022

Resistance to checkpoint-blockade treatments is a challenge in the clinic. Both primary and acquired resistance have become major obstacles, greatly limiting the long-lasting effects and wide application of blockade therapy. Many patients with metastatic melanoma eventually require further therapy. The absence of T-cell infiltration to the tumor site is a well-accepted contributor limiting immune checkpoint inhibitor efficacy. In this study, we combined intratumoral injection of plasmid IL-12 with electrotransfer and anti-PD-1 in metastatic B16F10 melanoma tumor model to increase tumor-infiltrating lymphocytes and improve therapeutic efficacy. We showed that effective anti-tumor responses required a subset of tumor-infiltrating CD8+ and CD4+ T cells. Additionally, the combination therapy induced higher MHC-I surface expression on tumor cells to hamper tumor cells escaping from immune recognition. Furthermore, we found that activating T cells by exposure to IL-12 resulted in tumors sensitized to anti-PD-1 treatment, suggesting a therapeutic strategy to improve responses to checkpoint blockade.
Amidated Pluronic Decorated Muco-Penetrating Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Improved Anti-Salmonella typhi Potential
Authors: Arshad Rabia , Arshad Muhammad Salman , Tabish Tanveer A. , Shah Syed Nisar Hussain , Afzal Saira , Shahnaz Gul
Published: November 2022

The enteric system residing notorious Salmonella typhimurium (S. typhi) is an intracellular, food-borne, and zoonotic pathogen causing typhoid fever. Typhoid fever is one of the leading causes of mortality and morbidity in developing and underdeveloped countries. It also increased the prevalence of multidrug resistance globally. Currently, available anti-bacterial modalities are unable to penetrate into the intracellular compartments effectively for eradicating S. typhi infection. Therefore, in this study, we developed nanostructured lipid-based carriers in the form of a self-nanoemulsifying drug delivery system (SNEDDS) for targeted delivery of ciprofloxacin (CIP) into the S. typhi intracellular reservoirs. Capryol 90, Tween 80, and Span 20 were finalized as suitable oil, surfactant, and co-surfactant, respectively, according to the pseudoternary phase diagram emulsifying region. Targeting capability and mucopenetration of the SNEDDS was attributed to the inclusion of amidated pluronic (NH2-F127). Developed NH2-F127 SNEDDS were characterized via physicochemical, in vitro, ex vivo, and in vivo evaluation parameters. The size of the SNEDDS was found to be 250 nm, having positively charged zeta potential. In vitro dissolution of SNEDDS showed 80% sustained release of CIP in 72 h with maximum entrapment efficiency up to 90% as well as good hemocompatibility by showing less than 0.2% hemolysis and 90% biocompatibility. The survival rate of S. typhi in macrophages (RAW 264.7) was minimal, i.e., only 2% in the case of NH2-F127 SNEDDS. Macrophage uptake assay via nanostructures confirmed the maximum cellular uptake as evidenced by the highest fluorescence. Biofilm dispersion assay showed rapid eradication of developed resistant biofilms on the gall bladder. In vivo pharmacokinetics showed improved bioavailability by showing an increased area under the curve (AUC) value. Taken together, NH2-F127-SNEDDS can be utilized as an alternative and efficient delivery system for the sustained release of therapeutic amounts of CIP for the treatment of S. typhi.
Instrumental Activities of Daily Living Tools in Very-Low Vision: Ready for Use in Trials?
Authors: Terheyden Jan Henrik , Fink David J. , Pondorfer Susanne G. , Holz Frank G. , Finger Robert P.
Published: November 2022

Traditional endpoints assessing visual function are limited by their responsiveness to interventions restoring or maintaining vision. An alternative concept is assessing instrumental activities of daily living (IADL). Herein, we review all available vision-specific IADL instruments relevant for vision restoration trials and report data for the most promising instrument. Six relevant instruments exist: The Low Vision Functional Status Evaluation (LVFSE), Timed IADL (TIADL), Melbourne Low-Vision Activities of Daily Living Index (MLVAI), Assessment of Disability Related to Vision (ADREV), Functional Low-Vision Observer Rated Assessment (FLORA), and Very Low Vision IADL (IADL-VLV). Both internal consistency and test-retest data were available for the LVFSE, MLVAI, and IADL-VLV. In a sample from a low-vision clinic (n = 51; age 57 ± 16 years), we report additional validation data on the IVI-VLV including test–retest reliability (intraclass correlation coefficient 0.981 [0.961; 0.991]). The LVSFE was noticeably less reliable than the MLVAI and the IADL-VLV. Content and construct validity data were available for the LVFSE, TIADL, MLVAI, ADREV, and IADL-VLV, but only the MLVAI and IADL-VLV were developed for an ultra-low vision context. Ceiling effects were present across instruments. Thus, of all appropriate IADL instruments related to vision, the IADL-VLV and MLVAI best meet existing requirements for use in vision restoration trials, e.g., in gene therapies or visual prostheses in inherited retinal diseases, but require further validation.
The Use of Medicinal Plant-Derived Metallic Nanoparticles in Theranostics
Authors: Xulu Jabulile Happiness , Ndongwe Tanaka , Ezealisiji Kenneth M. , Tembu Vuyelwa J. , Mncwangi Nontobeko P. , Witika Bwalya A. , Siwe-Noundou Xavier
Published: November 2022

In the quest to effectively diagnose and treat the diseases that afflict mankind, the development of a tool capable of simultaneous detection and treatment would provide a significant cornerstone for the survival and control of these diseases. Theranostics denotes a portmanteau of therapeutics and diagnostics which simultaneously detect and treat ailments. Research advances have initiated the advent of theranostics in modern medicine. Overall, theranostics are drug delivery systems with molecular or targeted imaging agents integrated into their structure. The application of theranostics is rising exponentially due to the urgent need for treatments that can be utilized for diagnostic imaging as an aid in precision and personalised medicine. Subsequently, the emergence of nanobiotechnology and the green synthesis of metallic nanoparticles (MNPs) has provided one such avenue for nanoscale development and research. Of interest is the drastic rise in the use of medicinal plants in the synthesis of MNPs which have been reported to be potentially effective in the diagnosis and treatment of diseases. At present, medicinal plant-derived MNPs have been cited to have broad pharmacological applications and have been studied for their potential use in the treatment and management of cancer, malaria, microbial and cardiovascular diseases. The subject of this article regards the role of medicinal plants in the synthesis of MNPs and the potential role of MNPs in the field of theranostics.
Automated Parallel Dialysis for Purification of Polymers
Authors: Terzioğlu İpek , Ventura-Hunter Carolina , Ulbrich Jens , Saldívar-Guerra Enrique , Schubert Ulrich , Guerrero-Sánchez Carlos
Published: November 2022

The implementation of a dialysis method for the simultaneous purification of different polymer materials in a commercially available automated parallel synthesizer (APS) is discussed. The efficiency of this “unattended” automated parallel dialysis (APD) method was investigated by means of proton nuclear magnetic resonance (1H-NMR) measurements, which confirmed that the method enables the removal of up to 99% of the unreacted monomer derived from the synthesis of the corresponding polymers in the APS. Size-exclusion chromatography (SEC) revealed that the molar mass and molar mass distribution of the investigated polymers did not undergo significant changes after the application of the APD method. The method discussed herein can be regarded as a good alternative to the “unattended” and reliable purification of polymer libraries prepared in APS. This method may be useful for overcoming current limitations of high-throughput/-output (HT/O) synthesis of polymer libraries, where purification of the generated materials currently represents a significant constraint for establishing fully automated experimental workflows necessary to advance towards a full digitalization of research and development of new polymers for diverse applications.
Effect of Different Types of Aluminosilicates on the Thermo-Mechanical Properties of Metakaolinite-Based Geopolymer Composites
Authors: Kohout Jan , Koutník Petr , Hájková Pavlína , Kohoutová Eliška , Soukup Aleš
Published: November 2022

In this study, the effect of different types of aluminosilicates on the thermo-mechanical properties of metakaolinite-based geopolymer binders and composites was examined. The metakaolinite-based geopolymer binders and composites were produced from three different types of aluminosilicates (one metakaolin and two calcined claystones) and a potassium alkaline activator. Chamotte was added as a filler, amounting to 65% by volume, to create geopolymer composites. Geopolymer binders were characterized by X-ray diffraction, rotary rheometer and scanning electron microscopy. The mechanical properties, thermal dilatation and thermal conductivity were investigated on geopolymer composites with three different aluminosilicates before and after exposure to high temperatures (up to 1200 °C). The results showed that the geopolymer binders prepared from calcined claystones had a lower dynamic viscosity (787 and 588 mPa·s) compared to the geopolymer binders prepared from metakaolin (1090 mPa·s). Geopolymer composites based on metakaolin had lower shrinkage (0.6%) and higher refractoriness (1520 °C) than geopolymers from calcined claystones (0.9% and 1.5%, 1500 °C and 1470 °C). Geopolymers based on calcined kaolinitic claystones are a promising material with higher compressive (95.2 and 71.5 MPa) and flexural strength (12.4 and 10.7 MPa) compared to geopolymers based on metakaolin (compressive strength 57.7 MPa).
Cellulose in Secondary Xylem of Cactaceae: Crystalline Composition and Anatomical Distribution
Authors: Maceda Agustín , Soto-Hernández Marcos , Terrazas Teresa
Published: November 2022

Cellulose is the main polymer that gives strength to the cell wall and is located in the primary and secondary cell walls of plants. In Cactaceae, there are no studies on the composition of cellulose. The objective of this work was to analyze the crystallinity composition and anatomical distribution of cellulose in Cactaceae vascular tissue. Twenty-five species of Cactaceae were collected, dried, and milled. Cellulose was purified and analyzed with Fourier transform infrared spectroscopy, the crystallinity indexes were calculated, and statistical analyzes were performed. Stem sections were fixed, cut, and stained with safranin O/fast green, for observation with epifluorescence microscopy. The crystalline cellulose ratios had statistical differences between Echinocereus pectinatus and Coryphantha pallida. All cacti species presented a higher proportion of crystalline cellulose. The fluorescence emission of the cellulose was red in color and distributed in the primary wall of non-fibrous species; while in the fibrous species, the distribution was in the pits. The high percentages of crystalline cellulose may be related to its distribution in the non-lignified parenchyma and primary walls of tracheary elements with helical or annular thickenings of non-fibrous species, possibly offering structural rigidity and forming part of the defense system against pathogens.
Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy
Authors: Dong Xingyu , Tian Yuan , Wang Fengqing , Chen Chong , Wang Yunlong , Ma Jun
Published: November 2022

Radio-fluorogenic hydrogel dosimeters are urgently needed in radiotherapy for 3D dose verification. However, few hydrogel sensors have been reported at low absorbed doses under 2 Gy which meets the requirements of clinical practice. Here, we report a new type of gold-nanoparticle-enhanced radio-fluorogenic agarose hydrogel with coumarin as the dose-responsive material. An optimal composition of 3 wt% of agarose, 0.1 mM of gold nanoparticles, and 0.5 mM coumarin was selected. The addition of gold nanoparticles enhanced the hydroxyl radicals generated from the radiolysis of water, which can react with coumarin and generate fluorescent 7-hydroxy-coumarin and, eventually, achieve low-dose verification of 0–2.4 Gy with a high linear correlation coefficient. These findings provide an effective method for 3D dose verification, and will inspire the development of other radio-fluorogenic sensing hydrogels as well.
Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review
Authors: Ahmad Shariff Siti Hajar , Wan Abdul Khodir Wan Khartini , Abd Hamid Shafida , Haris Muhammad Salahuddin , Ismail Mohamad Wafiuddin
Published: November 2022

Recently, drug delivery systems based on nanoparticles for cancer treatment have become the centre of attention for researchers to design and fabricate drug carriers for anti-cancer drugs due to the lack of tumour-targeting activity in conventional pharmaceuticals. Poly(caprolactone)-b-poly(ethylene glycol) (PCL-PEG)-based micelles have attracted significant attention as a potential drug carrier intended for human use. Since their first discovery, the Food and Drug Administration (FDA)-approved polymers have been studied extensively for various biomedical applications, specifically cancer therapy. The application of PCL-PEG micelles in different cancer therapies has been recorded in countless research studies for their efficacy as drug cargos. However, systematic studies on the effectiveness of PCL-PEG micelles of specific cancers for pharmaceutical applications are still lacking. As breast cancer is reported as the most prevalent cancer worldwide, we aim to systematically review all available literature that has published research findings on the PCL-PEG-based micelles as drug cargo for therapy. We further discussed the preparation method and the anti-tumour efficacy of the micelles. Using a prearranged search string, Scopus and Science Direct were selected as the databases for the systematic searching strategy. Only eight of the 314 articles met the inclusion requirements and were used for data synthesis. From the review, all studies reported the efficiency of PCL-PEG-based micelles, which act as drug cargo for breast cancer therapy.
Analysis of Particle Variation Effect on Flexural Properties of Hollow Glass Microsphere Filled Epoxy Matrix Syntactic Foam Composites
Authors: Afolabi Olusegun Adigun , Kanny Krishnan , Mohan Turup Pandurangan
Published: November 2022

Syntactic foam made from hollow glass microspheres (HGM) in an epoxy matrix has proven to be a good material with a strong structural strength. Understanding filler particle size variation is important in composite material formation, especially in syntactic foam, because of its numerous applications such as aerospace, marine, and structural purposes. In this present work, the effects of particle variation in different sizes (20–24 µm, 25–44 µm, 45–49 µm, and 50–60 µm) on the mechanical properties of the syntactic foam composites with a focus on flexural strength, modulus, and fracture surfaces are investigated. The particle sizes are varied into five volume fractions (5, 10, 15, 20, and 25 vol%). The results show that the highest flexural strength is 89 MPa at a 5 vol% fraction of 50–60 µm particle size variation with a 69% increase over the neat epoxy. This implies that the incorporation of HGM filler volume fraction and size variation has a strong effect on the flexural strength and bending modulus of syntactic foam. The highest particle size distribution is 31.02 at 25–44 µm. The storage modulus E’ increased at 30 °C, 50 °C, and 60 °C by 3.2%, 47%, and 96%, respectively. The effects of wall thickness and aspect ratio on the size of the microstructure, the fracture surfaces, and the viscoelastic properties are determined and reported accordingly.
Mechanical Characterization of Hybrid Nano-Filled Glass/Epoxy Composites
Authors: Rajhi Ali A.
Published: November 2022

Fiber-reinforced polymer (FRP) composite materials are very versatile in use because of their high specific stiffness and high specific strength characteristics. The main limitation of this material is its brittle nature (mainly due to the low stiffness and low fracture toughness of resin) that leads to reduced properties that are matrix dominated, including impact strength, compressive strength, in-plane shear, fracture toughness, and interlaminar strength. One method of overcoming these limitations is using nanoparticles as fillers in an FRP composite. Thereby, this present paper is focused on studying the effect of nanofillers added to glass/epoxy composite materials on mechanical behavior. Multiwall carbon nanotubes (MWCNTs), nano-silica (NS), and nano-iron oxide (NFe) are the nanofillers selected, as they can react with the resin system in the present-case epoxy to contribute a significant improvement to the polymer cross-linking web. Glass/epoxy composites are made with four layers of unidirectional E-glass fiber modified by nanoparticles with four different weight percentages (0.1%, 0.2%, 0.5%, and 1.0%). For reference, a sample without nanoparticles was made. The mechanical characterizations of these samples were completed under tensile, compressive, flexural, and impact loading. To understand the failure mechanism, an SEM analysis was also completed on the fractured surface.
Position Tracking of an Underwater Robot Based on Floating-Downing PI Control
Authors: Kuo Chao-Lin , Pu Yu-Chi , Chen Qi-An
Published: November 2022

A remotely operated underwater vehicle (ROV) is crucial in ocean exploration and underwater missions. An ROV is manipulated through a tether cable by an operator on shore or mother boat, and it can be used for underwater observations or as a robotic arm to take samples back. The position control and movement of an ROV are not stable due to buoyancy, ocean current, and surge waves. To overcome the influence of these disturbances on the ROV, we propose a switch proportional-integral (PI) controller combined with a buck-boost converter (BBC) to process the ROV’s position following. In this paper, a six-axis ROV was designed and implemented. The ROV controller was designed by a NI-roboRIO-based embedded system, which includes a pressure sensor, an accelerometer, six thrusters, and two webcams. The LabVIEW human–machine interface was designed to integrate the control system, sensors, and thrusters. The PI controller was employed to perform the station-keeping and trajectory following. Different PI control parameters were used for the ROV floating-up and diving-down in the sine-wave trajectory following. Experimental results showed that the proposed switch PI control scheme is robust for the position tracking of the underwater robot. The contribution of this study is that we proposed a novel switch proportional-integral controller combined with a buck-boost converter and applied the controller to a natural underwater vehicle, not a mathematical model. The experiments showed that the proposed controller can resist the disturbance of the aquatic environment.
Prediction of Soil Water Thresholds for Trees in the Semi-Arid Region on the Loess Plateau
Authors: Chi Chunming , Wang Jingjing , Zhi Jinhu
Published: November 2022

It is important to obtain the soil water content threshold (θTHR) for agricultural water management. However, the measurement of θTHR is time consuming and needs specialized and expensive equipment. The accuracy of the empirical estimates is often low. Therefore, the development of a simple, rapid, and accurate prediction method for θTHR is the focus of the present study. The value of θTHR is regarded as the soil water content at the capillary break capacity (θCB). A formula based on field capacity (θFC) and soil bulk density (Db) is proposed to calculate θCB, expressed as θCB=θFC−0.21*1−Db/2.65. Six soils from six published studies on the response of tree physiological processes to water deficit were used to calculate θCB using this formula. The calculated θCB values were compared with the measured θTHR. The results showed that the calculated θCB values were nearly equal to the measured θTHR. A highly significant (adj R2 = 0.9826, p < 0.001) linear relationship with a slope of 0.9506 and a y intercept of 0.0072 was found between the calculated θCB and measured θTHR. The formula proposed in this study provides a novel approach for estimating the θTHR of trees in the semi-arid regions on the Loess Plateau.
Creator Theology and Sterba’s Argument from Evil
Authors: Milburn Joe
Published: November 2022

In this paper, I reformulate Sterba’s argument from evil and consider the various ways theists might respond to it. There are two basic families of responses. On the one hand, theists can deny that God, as a perfect being, needs to act in accordance with Sterba’s moral evil prevention requirements (MEPRs). We can call these responses exceptionalist responses. On the other hand, the theist can deny that God’s acting in accordance with the MEPRs would imply an absence of significant and especially horrendous evil consequences of immoral actions in the world. We can call these responses compatibilist responses. I argue that the availability of both sorts of responses shows that Sterba’s argument should not be taken as a logical argument from evil. A good God is logically possible. However, this does not show that Sterba’s argument fails as an evidential argument from evil. In the second section, I argue that if we work within the framework of what Jonathan Kvanvig calls Creator Theology (CT), the force of Sterba’s argument as an evidential argument is greatly weakened.
An Atheistic Argument from Naturalistic Explanations of Religious Belief: A Preliminary Reply to Robert Nola
Authors: Kwan Kai-man
Published: November 2022

Robert Nola has recently defended an argument against the existence of God on the basis of naturalistic explanations of religious belief. I will critically evaluate his argument in this paper. Nola’s argument takes the form of an inference to the best explanation: since the naturalistic stance offers a better explanation of religious belief relative to the theistic explanation, the ontology of God(s) is eliminated. I rebut Nola’s major assumption that naturalistic explanations and theistic explanations of religion are incompatible. I go on to criticize Nola’s proposed naturalistic explanations: Freudianism, a Hypersensitive Agency Detection Device, and a Moralising Mind-Policing God. I find these inadequate as actual explanations of religious belief. Even if they are correct, they will not show that theism is false. So Nola’s argument fails to convince.
Use of Chipless RFID as a Passive, Printable Sensor Technology for Aerospace Strain and Temperature Monitoring
Authors: Mc Gee Kevin , Anandarajah Prince , Collins David
Published: November 2022

This paper was concerned with the current level of progress towards the development of chipless radio frequency identification (RFID) sensors that are capable of sensing strain and temperature. More specifically, it was interested in the possibility that the resulting devices could be used as a passive wireless structural health monitoring (SHM) sensor technology that could be printed in situ. This work contains the development and performance characterization results for both novel strain and novel temperature sensor designs with resulting sensitivities of 9.77 MHz/%ε and 0.88 MHz/°C, respectively. Furthermore, a detailed discussion on the interrogation system required to meet the relevant aerospace sensing requirements was also discussed, and several methods were explored to enhance the multi-sensor support capabilities of this technology.
A Quantum Ring Laser Gyroscope Based on Coherence de Broglie Waves
Authors: Ham Byoung S.
Published: November 2022

In sensors, the highest precision in measurements is given by vacuum fluctuations of quantum mechanics, resulting in a shot noise limit. In a Mach–Zenhder interferometer (MZI), the intensity measurement is correlated with the phase, and thus, the precision measurement (Δn) is coupled with the phase resolution (Δφ) by the Heisenberg uncertainty principle. Quantum metrology offers a different solution to this precision measurement using nonclassical light such as squeezed light or higher-order entangled-photon pairs, resulting in a smaller Δφ and sub-shot noise limit. Here, we propose another method for the high precision measurement overcoming the diffraction limit in classical physics, where the smaller Δφ is achieved by phase quantization in a coupled interferometric system of coherence de Broglie waves. For a potential application of the proposed method, a quantum ring laser gyroscope is presented as a quantum version of the conventional ring laser gyroscope used for inertial navigation and geodesy.