bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemetaan Peningkatan Kinerja UMKM melalui Sistem Fraction Cluster
Authors: Khusnatul Zulfa Wafirotin  , Slamet Santoso  , Yeni Cahyono  , Iin Wijayanti  , Riza Rizadesi
Published: October 2023

Abstract:  Mapping the Improvement of MSME Performance through the Fraction Cluster System
Purpose: The paper seeks to provide the mapping of MSME performance to portrait the improvement of their performance.
Method: The paper employes quantitative approach, the  population and sample in this research were 75 MSMEs.
Results: The results of this research show that an understanding of accounting and the underlying knowledge related to accounting can provide a good role in supporting the performance of MSMEs. Managerial ability in leading an MSME is also important in directing and maintaining the stability of an MSME
Novelty: The findings from this research are presented using fraction cluster system.
Contribution: Competition is increasingly complex and  so are the challenges in developing MSMEs. Many MSMEs suffer losses. This paper contributes to urge government support for MSMEs to improve the nation’s and  state’s economy.
Abstrak: Pemetaan Peningkatan Kinerja UMKM melalui Sistem Fraction Cluster
Tujuan: Penelitian ini bertujuan menyediakan pemetaan kinerja UMKM untuk memotret peningkatan kinerja mereka.
Metode: Penelitian ini menggunakan pendekatan kuantitatif. Sebanyak 75 UMKM diambil sebagai sampel.
Hasil: Hasil penelitian ini menunjukkan bahwa pemahaman dan pengetahuan yang mendasari terkait akuntansi dapat memberikan peran yang baik dalam menunjang kinerja UMKM. Kemampuan manajerial dalam memimpin suatu UMKM juga penting dalam mengarahkan dan menjaga stabilitas suatu UMKM
Kebaruan: Hasil penelitian ini disajikan dengan menggunakan sistem fraction cluster.
Kontribusi: Persaingan semakin kompleks dan begitu pula tantangan dalam mengembangkan UMKM. Banyak UMKM yang mengalami kerugian. Artikel ini berkontribusi untuk mendesak dukungan pemerintah terhadap UMKM guna meningkatkan perekonomian bangsa dan negara.
ANALISIS MEDIA PELAYANAN APLIKASI DJP ONLINE TERHADAP PENERIMAAN TEKNOLOGI WAJIB PAJAK
Authors: Nurdin Ivan
Published: October 2023

Penelitian ini dilatarbelakangi oleh fenomena kepatuhan wajib pajak, serta perilaku wajib pajak yang masih mengunjungi kantor pajak. Padahal Dirjen Pajak Kementerian Keuangan Republik Indonesia telah menciptakan aplikasi berbasis web, yang bertujuan untuk efektifitas dan efisiensi pelayanan publik. Perubahan yang disebabkan oleh perkembangan teknologi menjadi sebuah kepastian. Marshall Mcluhan mencetuskan teori ekologi media, yang berdasar pada pengaruh media elektronik dalam penggunaan teknologi, penerimaan bahasa, serta interaksi yang terjadi dapat memberikan perubahan terhadap perilaku individu. Pada penelitian ini Technology Acceptance Model (TAM) merupakan model yang digunakan untuk mengidentifikasi tingkat penggunaan aplikasi DJP Online, kemudahan yang didapatkan, serta dampak perilaku yang dihasilkan setelah menggunakan aplikasi tersebut. Penelitian ini menggunakan metode Interpretative Phenomenological Analysis (IPA), dengan pendekatan kualitatif, dan paradigma konstruktivis. Penelitian ini menggambarkan realitas sosial untuk mendapatkan pemahaman komprehensif tentang pengalaman wajib pajak dalam menggunakan aplikasi DJP Online. Penelitian ini menggunakan teknik wawancara semi terstruktur, observasi dan studi pustaka. Penelitian ini menunjukkan bahwa wajib pajak mengalami kesulitan dalam memahami istilah perpajakan, penggunaan aplikasi yang rumit, dan merasakan kurangnya sosialisasi yang diberikan oleh pemerintah. Hasilnya wajib pajak ada yang tetap mendatangi kantor pajak, dan ada juga yang memanfaatkan media teknologi lain untuk mendapatkan informasi lebih tentang aplikasi DJP Online
Collaborative problem solving: A pedagogy for workplace relevance
Authors: Halttunen Timo , Dragin-Jensen Christian , Kylänpää Céline , Karkov Anders
Published: October 2023

Collaborative problem solving (CPS) is a widely used pedagogical approach in work-based learning. To facilitate the complex process of situated learning, researchers have emphasized the need for scaffolding to enable learning of skills while engaged in problem-solving. While CPS as a pedagogical practice has mainly been examined in classroom situations, a research gap exists in studies of CPS in real-world contexts. In this study, we contribute to the understanding of CPS by examining the contextual characteristics that shape students’ and teachers’ experiences in situated learning. Consequently, we present a multi-case study to investigate involvement of a business professional as a source for scaffolding on site, in a hotel business environment. We employed a qualitative, multi-case methodology in the study. An ill-structured, real-world problem of food waste in the hotel service sector was presented to students (N = 72) and their accompanying teachers (N = 9) from second and tertiary education. They were provided with access to expert knowledge and opinion by industry professionals (N=5) on site. We collected data via observations, interviews, and questions from the involved stakeholders in three physical locations in Denmark and in Finland. Additionally, we documented their experiences using an online collaboration tool in each case. Despite the scaffolding provided by the business professionals, students underused the resources available for their learning in the extended learning environment. Students benefited from guided exploration of the problem space, structured feedback, and teacher interventions, resulting in improved perspective taking, participation, social regulation, task regulation and knowledge building.
Calcium sulfate-Cu2+ delivery system improves 3D-Printed calcium silicate artificial bone to repair large bone defects
Authors: Gao Shijie , Li Jiawen , Lei Qingjian , Chen Yan , Huang Huayi , Yan Feifei , Xiao Lingfei , Zhang Tie , Wang Linlong , Wei Renxiong , Hu Chao
Published: October 2023

There are still limitations in artificial bone materials used in clinical practice, such as difficulty in repairing large bone defects, the mismatch between the degradation rate and tissue growth, difficulty in vascularization, an inability to address bone defects of various shapes, and risk of infection. To solve these problems, our group designed stereolithography (SLA) 3D-printed calcium silicate artificial bone improved by a calcium sulfate-Cu2+ delivery system. SLA technology endows the scaffold with a three-dimensional tunnel structure to induce cell migration to the center of the bone defect. The calcium sulfate-Cu2+ delivery system was introduced to enhance the osteogenic activity of calcium silicate. Rapid degradation of calcium sulfate (CS) induces early osteogenesis in the three-dimensional tunnel structure. Calcium silicate (CSi) which degrades slowly provides mechanical support and promotes bone formation in bone defect sites for a long time. The gradient degradation of these two components is perfectly matched to the rate of repair in large bone defects. On the other hand, the calcium sulfate delivery system can regularly release Cu2+ in the temporal and spatial dimensions, exerting a long-lasting antimicrobial effect and promoting vascular growth. This powerful 3D-printed calcium silicate artificial bone which has rich osteogenic activity is a promising material for treating large bone defects and has excellent potential for clinical application.
Serum mannan-binding lectin-associated serine proteases in early pregnancy for gestational diabetes in Chinese pregnant women
Authors: Gao Ming , Li Jing , Zhang Rui , Li Ninghua , Li Weiqin , Zhang Shuang , Wang Peng , Wang Hui , Fang Zhongze , Yu Zhijie , Hu Gang , Leng Junhong , Yang Xilin
Published: October 2023

Aims

This study aimed to explore associations of mannan-binding lectin-associated serine protease (MASP) levels in early pregnancy with gestational diabetes mellitus (GDM). We also examined interactions of MASPs and deoxycholic acid (DCA)/glycoursodeoxycholic acid (GUDCA) for the GDM risk and whether the interactive effects if any on the GDM risk were mediated via lysophosphatidylcholine (LPC) 18:0.

Materials and methods

A 1:1 case-control study (n = 414) nested in a prospective cohort of pregnant women was conducted in Tianjin, China. Binary conditional logistic regressions were performed to examine associations of MASPs with the GDM risk. Additive interaction measures were used to examine interactions between MASPs and DCA/GUDCA for the GDM risk. Mediation analyses and Sobel tests were used to examine mediation effects of LPC18:0 between the copresence of MASPs and DCA/GUDCA on the GDM risk.

Results

High MASP-2 was independently associated with GDM [odds ratio (OR): 2.62, 95% confidence interval (CI): 1.44–4.77], while the effect of high MASP-1 on GDM was attributable to high MASP-2 (P for Sobel test: 0.003). Low DCA markedly increased the OR of high MASP-2 alone from 2.53 (1.10–5.85) up to 10.6 (4.22–26.4), with a significant additive interaction. In addition, high LPC18:0 played a significant mediating role in the links from low DCA to GDM and from the copresence of high MASP-2 and low DCA to GDM (P for Sobel test <0.001) but not in the link from high MASP-2 to GDM.

Conclusions

High MASP-1 and MASP-2 in early pregnancy were associated with GDM in Chinese pregnant women. MASP-2 amplifies the risk of low DCA for GDM, which is mediated via LPC18:0.
Skin transcriptomic correlates of cave-dwelling Sinocyclocheilus cavefish
Authors: Luo Xiayue , Chen Bing , Mao Tingru , Liu Yewei , Yang Jian , Meegaskumbura Madhava
Published: October 2023

Introduction

With 78 species, Sinocyclocheilus cavefish constitute the largest cavefish radiation in the world. They exhibit remarkable morphological diversity across three habitat types: surface (surface morphs, normal-eyed, variably colored), exclusively-cave-dwelling (stygobitic morphs, eyeless, depigmented), and intermediate between cave and surface (stygophilic morphs, micro-eyed, partially depigmented). Distinctive traits of Sinocyclocheilus include variations in eye and skin conditions associated with their habitat, despite the role of the skin in sensing environmental changes, its habitat correlates are less understood, compared to the well-studied eye conditions.

Methods

Here, we analyzed the correlation between Sinocyclocheilus skin morphology and its habitat, utilizing morphological and transcriptomics-based methods. We generated skin RNA-sequencing data for nine species and integrated those with existing data from five additional species. These 14 species represent the primary clades and major habitats of these cavefish.

Result

We identified 7,374 orthologous genes in the skin transcriptome data. Using a comparative transcriptomics approach, 1,348 differentially expressed genes (DEGs) were identified in the three morphotypes. GO and KEGG enrichment analyses suggested that these genes were mainly involved in energy metabolism, immunity and oxidative stress-related functions. Genes related to immune, apoptotic, and necrotic functions were identified through positive selection analysis of orthologous genes. The maximum likelihood phylogenetic tree, based on 1,369, single-copy orthologous genes of the species, was largely concordant with the currently established RAD-seq and mt-DNA based phylogenies. Species with higher cave dependence present lighter coloration, fewer dark blotches, and diminished scale morphology and coverage. We also found that differences in skin gene expression and positive selection effects may have contributed to the degradation of skin color and scales.

Discussion

Our study highlights the significance of habitat in shaping skin metabolism, pigmentation variation, and morphology while offering insights into the molecular mechanisms driving these habitat-specific adaptations in Sinocyclocheilus. These findings underscore the transcriptional variation in adapting to diverse environments and contribute to future studies on the evolution and ecology of cavefish.
ONECUT1 variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts
Authors: Dashti Mohammed , Nizam Rasheeba , John Sumi Elsa , Melhem Motasem , Channanath Arshad , Alkandari Hessa , Thanaraj Thangavel Alphonse , Al-Mulla Fahd
Published: October 2023

ONECUT1 gene, encoding hepatocyte nuclear factor 6, is involved in pancreas and liver development. ONECUT1 mutations impair the function of pancreatic β-cells and control a transcriptional/epigenetic machinery regulating endocrine development. Homozygous nonsense and missense mutations at ONECUT1_p.E231 and a homozygous frameshift mutation at ONECUT1_p.M289 were reported in neonatal diabetes individuals of French, Turkish, and Indian ethnicity, respectively. Additionally, heterozygous variants were observed in Northern European T2D patients, and Italian patients with neonatal diabetes and early-/late-onset T2D. Examining diverse populations, such as Arabs known for consanguinity, can generalize the ONECUT1 involvement in diabetes. Upon screening the cohorts of Kuwaiti T1D and MODY families, and of Kuwaiti and Qatari T2D individuals, we observed two homozygous variants—the deleterious missense rs202151356_p.H33Q in one MODY, one T1D, and two T2D individuals, and the synonymous rs61735385_p.P94P in two T2D individuals. Heterozygous variants were also observed. Examination of GTEx, NephQTL, mQTLdb and HaploReg highlighted the rs61735385_p.P94P variant as eQTL influencing the tissue-specific expression of ONECUT1, as mQTL influencing methylation at CpG sites in and around ONECUT1 with the nearest site at 677-bases 3′ to rs61735385_p.P94P; as overlapping predicted binding sites for NF-kappaB and EBF on ONECUT1. DNA methylation profiles of peripheral blood from 19 MODY-X patients versus eight healthy individuals revealed significant hypomethylation at two CpG sites—one located 617-bases 3′ to the p.P94P variant and 8,102 bases away from transcription start; and the other located 14,999 bases away from transcription start. Our study generalizes the association of ONECUT1 with clinical diversity in diabetes.
X-ray phase-contrast 3D virtual histology characterises complex tissue architecture in colorectal cancer
Authors: Svetlove Angelika , Griebel Titus , Albers Jonas , D’Amico Lorenzo , Nolte Philipp , Tromba Giuliana , Bohnenberger Hanibal , Alves Frauke , Dullin Christian
Published: October 2023

Precise morphological analysis of tumour tissue samples is crucial for accurate diagnosis and staging of colorectal cancer (CRC), but remains limited by the 2D nature of conventional histology. Our aim is to offer a 3D representation of tissue samples by means of X-ray-based imaging to facilitate the evaluation of clinically relevant features in cancer tissue, a process that is currently subject to various restrictions. In this study, we show that propagation-based synchrotron radiation-based free propagation phase-contrast microcomputed tomography (SRµCT) is suitable for the generation of 3D tumour volumes with 2-µm voxel size using standard formalin-fixed, paraffin-embedded tissue from CRC patients and provides sufficient contrast for virtual histology. We demonstrate that, using an existing registration pipeline, a 2D histologic haematoxylin–eosin slice can be placed in the context of the 3D µCT volume. The precisely registered histologic section can then be used as a “seed point” for the segmentation and depiction of major histologic features. This approach allows for a more comprehensive understanding of the organisation of the tumour in space with respect to other structures such as vessels, fat, and lymph nodes, and has the potential to improve patients’ prognostic outcomes.
Advances in Mesenchymal stem cells regulating macrophage polarization and treatment of sepsis-induced liver injury
Authors: Chen Yuhao , Yang Lihong , Li Xihong
Published: October 2023

Sepsis is a syndrome of dysregulated host response caused by infection, which leads to life-threatening organ dysfunction. It is a familiar reason of death in critically ill patients. Liver injury frequently occurs in septic patients, yet the development of targeted and effective treatment strategies remains a pressing challenge. Macrophages are essential parts of immunity system. M1 macrophages drive inflammation, whereas M2 macrophages possess anti-inflammatory properties and contribute to tissue repair processes. Mesenchymal stem cells (MSCs), known for their remarkable attributes including homing capabilities, immunomodulation, anti-inflammatory effects, and tissue regeneration potential, hold promise in enhancing the prognosis of sepsis-induced liver injury by harmonizing the delicate balance of M1/M2 macrophage polarization. This review discusses the mechanisms by which MSCs regulate macrophage polarization, alongside the signaling pathways involved, providing an idea for innovative directions in the treatment of sepsis-induced liver injury.
Sex differences in neonatal brain injury and inflammation
Authors: Kelly Lynne A. , Branagan Aoife , Semova Gergana , Molloy Eleanor J.
Published: October 2023

Neonatal brain injury and associated inflammation is more common in males. There is a well-recognised difference in incidence and outcome of neonatal encephalopathy according to sex with a pronounced male disadvantage. Neurodevelopmental differences manifest from an early age in infancy with females having a lower incidence of developmental delay and learning difficulties in comparison with males and male sex has consistently been identified as a risk factor for cerebral palsy in epidemiological studies. Important neurobiological differences exist between the sexes with respect to neuronal injury which are especially pronounced in preterm neonates. There are many potential reasons for these sex differences including genetic, immunological and hormonal differences but there are limited studies of neonatal immune response. Animal models with induced neonatal hypoxia have shown various sex differences including an upregulated immune response and increased microglial activation in males. Male sex is recognized to be a risk factor for neonatal hypoxic ischemic encephalopathy (HIE) during the perinatal period and this review discusses in detail the sex differences in brain injury in preterm and term neonates and some of the potential new therapies with possible sex affects.
Dyslipidemia in rheumatoid arthritis: the possible mechanisms
Authors: Yan Jiahui , Yang Sisi , Han Liang , Ba Xin , Shen Pan , Lin Weiji , Li Tingting , Zhang Ruiyuan , Huang Ying , Huang Yao , Qin Kai , Wang Yu , Tu Shenghao , Chen Zhe
Published: October 2023

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, of which the leading cause of death is cardiovascular disease (CVD). The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) in RA decrease especially under hyperinflammatory conditions. It is conflictive with the increased risk of CVD in RA, which is called “lipid paradox”. The systemic inflammation may explain this apparent contradiction. The increased systemic proinflammatory cytokines in RA mainly include interleukin-6(IL-6)、interleukin-1(IL-1)and tumor necrosis factor alpha(TNF-α). The inflammation of RA cause changes in the subcomponents and structure of HDL particles, leading to a weakened anti-atherosclerosis function and promoting LDL oxidation and plaque formation. Dysfunctional HDL can further worsen the abnormalities of LDL metabolism, increasing the risk of cardiovascular disease. However, the specific mechanisms underlying lipid changes in RA and increased CVD risk remain unclear. Therefore, this article comprehensively integrates the latest existing literature to describe the unique lipid profile of RA, explore the mechanisms of lipid changes, and investigate the impact of lipid changes on cardiovascular disease.
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation
Authors: Tang Shun , Liang Yuanjing , Wang Minmin , Lei Jiarong , Peng Yuhui , Tao Qiu , Ming Tianqi , Yang Wenyu , Zhang Chuantao , Guo Jinlin , Xu Haibo
Published: October 2023

Acute lung injury (ALI) is a common condition, particularly in the COVID-19 pandemic, which is distinguished by sudden onset of respiratory insufficiency with tachypnea, oxygen-refractory cyanosis, reduced lung compliance and diffuse infiltration of pulmonary alveoli. It is well-established that increasing activity of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling axis and the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation are associated with the pathogenesis of ALI. Since ALI poses a huge challenge to human health, it is urgent to tackle this affliction with therapeutic intervention. Qinhuo Shanggan oral solution (QHSG), a traditional Chinese herbal formula, is clinically used for effective medication of various lung diseases including ALI, with the action mechanism obscure. In the present study, with the rat model of lipopolysaccharide (LPS)-induced ALI, QHSG was unveiled to ameliorate ALI by alleviating the pathological features, reversing the alteration in white blood cell profile and impeding the production of inflammatory cytokines through down-regulation of TLR4/NF-κB signaling cascade and inhibition of NLRP3 inflammasome activation. In LPS-stimulated RAW264.7 mouse macrophages, QHSG was discovered to hinder the generation of inflammatory cytokines by lessening TLR4/NF-κB signaling pathway activity and weakening NLRP3 inflammasome activation. Taken together, QHSG may resolve acute lung injury, attributed to its anti-inflammation and immunoregulation by attenuation of TLR4/NF-κB signaling cascade and inhibition of NLRP3 inflammasome activation. Our findings provide a novel insight into the action mechanism of QHSG and lay a mechanistic foundation for therapeutic intervention in acute lung injury with QHSG in clinical practice.
Microbial communities and mineral assemblages in sediments from various habitats at the Haima Cold Seep, South China Sea
Authors: Liang Jianzhen , Feng Jing-Chun , Kong Jie , Huang Yongji , Zhang Hui , Zhong Song , Tang Li , Zhang Si
Published: October 2023

Cold seeps create diverse habitats in the deep sea and play an important role in the global carbon cycling. Anaerobic oxidation of methane (AOM) and biogenic mineralization are essential carbon pathways of methane and carbon transformation in cold seeps, however, the effects of habitat heterogeneity on the processes are still poorly understood. In this study, we investigated the microbial communities and mineral assemblages at distinct habitats in the Haima cold seep and their relationships with environmental factors. These habitats were classified as methane seep site (MS), seep-free faunal habitat (FH), and control site (CS). Bacterial communities were significantly different among the three habitats. ANME-3 archaea, Sulfurovum bacteria, and mineralization-associated microbes (e.g., Campylobacterales) were detected in high relative abundances at ROV2. Mineralogical analysis revealed abundant calcite minerals at the seep site, indicating that authigenic carbonate minerals were formed at highly active seep. Multivariate statistical analysis demonstrated that the concentrations of SO42–, Ca2+, and Mg2+ were significantly correlated with the presence of calcite minerals and bacterial communities. These results suggested that AOM-accompanied authigenic carbonate formation is an important factor influencing the mineral assemblages in seep habitats. This finding improves our understanding of marine microbial carbon cycling.
Pioneering neurohackers: between egocentric human enhancement and altruistic sacrifice
Authors: Seyfried Günter , Youssef Sandra , Schmidt Markus
Published: October 2023

The growing field of neurotechnology (NT) is becoming more and more accessible in terms of reduced costs, increasing availability and reliability of materials, and ways to implant devices. As in other engineering fields such as bio-or information technology, there is a growing community of pioneering hackers who (self-)experiment with NT and develop novel applications. While most debates about NT, its goals and ethical ramifications are usually conducted by professionals in the field (neuroscientists, −engineers, −ethicists), little is known within these institutional frameworks about the motivations, goals and visions of neurohackers and how they view ethical ramifications of NT therapeutics vs. human enhancement. In this study we draw on qualitative interviews with 13 of these neurohacking pioneers, who are interacting with NT from a grassroots perspective (i.e., a bottom-up and community/subculture-oriented approach), and shed light on: how they understand themselves in the context of human enhancement; what the role of invasive NTs is when it comes to identifying as a cyborg; if their practices show a clear distinction between therapy and enhancement; whether human enhancement is always about performance, optimization and functionality; and to which extent neurohackers contribute to “mainstreaming” NT.
Improving robustness for model discerning synthesis process of uranium oxide with unsupervised domain adaptation
Authors: Ly Cuong , Nizinski Cody , Hagen Alex , McDonald Luther W , Tasdizen Tolga
Published: October 2023

The quantitative characterization of surface structures captured in scanning electron microscopy (SEM) images has proven to be effective for discerning provenance of an unknown nuclear material. Recently, many works have taken advantage of the powerful performance of convolutional neural networks (CNNs) to provide faster and more consistent characterization of surface structures. However, one inherent limitation of CNNs is their degradation in performance when encountering discrepancy between training and test datasets, which limits their use widely. The common discrepancy in an SEM image dataset occurs at low-level image information due to user-bias in selecting acquisition parameters and microscopes from different manufacturers. Therefore, in this study, we present a domain adaptation framework to improve robustness of CNNs against the discrepancy in low-level image information. Furthermore, our proposed approach makes use of only unlabeled test samples to adapt a pretrained model, which is more suitable for nuclear forensics application for which obtaining both training and test datasets simultaneously is a challenge due to data sensitivity. Through extensive experiments, we demonstrate that our proposed approach effectively improves the performance of a model by at least 18% when encountering domain discrepancy, and can be deployed in many CNN architectures.
Analysis of lower extremity alignment (LEA) in children with recurrent patellar dislocation by EOS system
Authors: Miao Mingyuan , Cai Haiqing , Zhang Li , Cai Haoqi
Published: October 2023

Objectives

Recurrent patellar dislocation (RPD) greatly affects active young individuals, necessitating the identification of risk factors for a better understanding of its cause. Previous research has connected RPD to lower limb alignment (LEA) abnormalities, such as increased femoral anteversion, tibial external rotation, knee valgus, and flexion. This study aims to use EOS technology to detect RPD-related LEA anomalies, enabling three-dimensional assessment under load conditions.

Methods

A total of 100 limbs (50 in the RPD group, 50 in the control group) were retrospectively analyzed. In the RPD group, we included limbs with recurrent patellar dislocation, characterized by dislocations occurs at least two times, while healthy limbs served as the control group. We used EOS technology, including 2D and 3D imaging, to measure and compare the following parameters between the two groups in a standing position: Femoral neck shaft angle (NSA), Mechanical femoral tibial angle (MFTA), Mechanical lateral distal femoral angle (mLDFA), Medial proximal tibial angle (MPTA), Anatomical femoral anteversion (AFA), External tibial torsion (ETT), and Femorotibial rotation (FTR).

Results

The significant differences between the two groups were shown in NSA 3/2D, MFTA 3/2D, mLDFA 3/2D, MPTA 3D, AFA, FTR. No significant difference was shown in MPTA 2D, ETT between the RPD group and the control group. Further binary logistic regression analysis. Further binary logistic regression analysis was conducted on the risk factors affecting RPD mentioned above. and found four risk factors for binary logistic regression analysis: mLDFA (3D), AFA, NSA(3D), and FTR.

Conclusions

EOS imaging identified abnormal LEA parameters, including NSA, MFTA, mLDFA, MPTA, AFA, and FTR, as risk factors for RPD. Children with these risk factors should receive moderate knee joint protection.
Influence of organic plant breeding on the rhizosphere microbiome of common bean (Phaseolus vulgaris L.)
Authors: Park Hayley E. , Nebert Lucas , King Ryan M. , Busby Posy , Myers James R.
Published: October 2023

Introduction

We now recognize that plant genotype affects the assembly of its microbiome, which in turn, affects essential plant functions. The production system for crop plants also influences the microbiome composition, and as a result, we would expect to find differences between conventional and organic production systems. Plant genotypes selected in an organic regime may host different microbiome assemblages than those selected in conventional environments. We aimed to address these questions using recombinant inbred populations of snap bean that differed in breeding history.

Methods

Rhizosphere microbiomes of conventional and organic common beans (Phaseolus vulgaris L.) were characterized within a long-term organic research site. The fungal and bacterial communities were distinguished using pooled replications of 16S and ITS amplicon sequences, which originated from rhizosphere samples collected between flowering and pod set.

Results

Bacterial communities significantly varied between organic and conventional breeding histories, while fungal communities varied between breeding histories and parentage. Within the organically-bred populations, a higher abundance of a plant-growth-promoting bacteria, Arthrobacter pokkalii, was identified. Conventionally-bred beans hosted a higher abundance of nitrogen-fixing bacteria that normally do not form functional nodules with common beans. Fungal communities in the organically derived beans included more arbuscular mycorrhizae, as well as several plant pathogens.

Discussion

The results confirm that the breeding environment of crops can significantly alter the microbiome community composition of progeny. Characterizing changes in microbiome communities and the plant genes instrumental to these changes will provide essential information about how future breeding efforts may pursue microbiome manipulation.
Promoting effects of soil C and N and limiting effect of soil P jointly determine the plant diversity during the aerial seeding restoration process in Mu Us sandy land, China
Authors: Gong Xiaoqian , Qi Zhimin , Wen Jia , Yan Yongzhi , Liu Qingfu , Li Yuanheng , Zhang Qing
Published: October 2023

Introduction

Exploring the change and maintaining mechanism of plant diversity is of great significance for guiding the restoration of degraded ecosystems. However, how plant taxonomic, functional, and phylogenetic diversity change during long-term ecosystem restoration process and their driving factors remain unclear.

Methods

Based on the 35-year time gradient of aerial seeding restoration in Mu Us sandy land, this study explored the changes in plant taxonomic, functional, and phylogenetic diversity and the driving factors.

Results

The results showed that plant taxonomic, functional, and phylogenetic diversity showed consistent response with the aerial seeding restoration, all of which increased first and then tended to a saturation state in the middle of restoration (14 years). TN, TOC, and NO3--N increased with aerial seeding restoration and showed a significant positive correlation with plant diversity of the three dimensions, while AP showed a negative correlation. Soil nitrogen and carbon promoted the increase of diversity of three dimensions in the early restoration period, while phosphorus limited the increase of diversity of three dimensions in the middle and late restoration periods. The diversity of three dimensions was mainly affected by restoration time, soil nutrients, and climate factors, and the coupling effect of restoration time and soil nutrients was dominant.

Discussion

These findings indicate that the plant diversity in different dimensions and soil nutrients are improved by aerial seeding restoration. Our study highlights that aerial seeding restoration mainly improves plant diversity by increasing soil nutrients, and the relative effects of different soil nutrients on plant diversity during restoration are inconsistent.
Classical singers are also proficient in non-classical singing
Authors: Bruder Camila , Larrouy-Maestri Pauline
Published: October 2023

Classical singers train intensively for many years to achieve a high level of vocal control and specific sound characteristics. However, the actual span of singers’ activities often includes venues other than opera halls and requires performing in styles outside their strict training (e.g., singing pop songs at weddings). We examine classical singers’ ability to adjust their vocal productions to other styles, in relation with their formal training. Twenty-two highly trained female classical singers (aged from 22 to 45 years old; vocal training ranging from 4.5 to 27 years) performed six different melody excerpts a cappella in contrasting ways: as an opera aria, as a pop song and as a lullaby. All melodies were sung both with lyrics and with a /lu/ sound. All productions were acoustically analyzed in terms of seven common acoustic descriptors of voice/singing performances and perceptually evaluated by a total of 50 lay listeners (aged from 21 to 73 years old) who were asked to identify the intended singing style in a forced-choice lab experiment. Acoustic analyses of the 792 performances suggest distinct acoustic profiles, implying that singers were able to produce contrasting sounding performances. Furthermore, the high overall style recognition rate (78.5% Correct Responses, hence CR) confirmed singers’ proficiency in performing in operatic style (86% CR) and their versatility when it comes to lullaby (80% CR) and pop performances (69% CR), albeit with occasional confusion between the latter two. Interestingly, different levels of competence among singers appeared, with versatility (as estimated based on correct recognition in pop/lullaby styles) ranging from 62 to 83% depending on the singer. Importantly, this variability was not linked to formal training per se. Our results indicate that classical singers are versatile, and prompt the need for further investigations to clarify the role of singers’ broader professional and personal experiences in the development of this valuable ability.
Development of the oppression-based traumatic stress inventory: a novel and intersectional approach to measuring traumatic stress
Authors: Holmes Samantha C. , Zalewa Daniel , Wetterneck Chad T. , Haeny Angela M. , Williams Monnica T.
Published: October 2023

There is a growing body of literature demonstrating that experiences of oppression (e.g., racism, sexism, heterosexism, poverty) are associated with posttraumatic stress disorder symptoms. Traditional trauma assessments do not assess experiences of oppression and it is therefore imperative to develop instruments that do. To assess oppression-based traumatic stress broadly, and in an intersectional manner, we have developed the oppression-based traumatic stress inventory (OBTSI). The OBTSI includes two parts. Part A comprises open-ended questions asking participants to describe experiences of oppression as well as a set of questions to determine whether Criterion A for PTSD is met. Part B assesses specific posttraumatic stress symptoms anchored to the previously described experiences of oppression and also asks participants to identify the various types of discrimination they have experienced (e.g., based on racial group, sex/gender, sexual orientation, etc.). Clients from a mental health clinic and an undergraduate sample responded to the OBTSI and other self-report measures of depression, anxiety, and traditional posttraumatic stress (N = 90). Preliminary analyses demonstrate strong internal consistency reliability for the overall symptom inventory (α = 0.97) as well as for the four symptom clusters of posttraumatic stress symptoms in the DSM-5 (α ranging from 0.86 to 0.94). In addition to providing descriptive information, we also assess the convergent validity between the OBTSI and measures of anxiety, depression, and traditional posttraumatic stress and examine the factor structure. This study provides preliminary evidence that the OBTSI is a reliable and valid method of assessing oppression-based traumatic stress symptoms.
Exploring objective measures for assessing team performance in healthcare: an interview study
Authors: Wespi Rafael , Birrenbach Tanja , Schauber Stefan K. , Manser Tanja , Sauter Thomas C. , Kämmer Juliane E.
Published: October 2023

Introduction

Effective teamwork plays a critical role in achieving high-performance outcomes in healthcare. Consequently, conducting a comprehensive assessment of team performance is essential for providing meaningful feedback during team trainings and enabling comparisons in scientific studies. However, traditional methods like self-reports or behavior observations have limitations such as susceptibility to bias or being resource consuming. To overcome these limitations and gain a more comprehensive understanding of team processes and performance, the assessment of objective measures, such as physiological parameters, can be valuable. These objective measures can complement traditional methods and provide a more holistic view of team performance. The aim of this study was to explore the potential of the use of objective measures for evaluating team performance for research and training purposes. For this, experts in the field of research and medical simulation training were interviewed to gather their opinions, ideas, and concerns regarding this novel approach.

Methods

A total of 34 medical and research experts participated in this exploratory qualitative study, engaging in semi-structured interviews. During the interview, experts were asked for (a) their opinion on measuring team performance with objective measures, (b) their ideas concerning potential objective measures suitable for measuring team performance of healthcare teams, and (c) their concerns regarding the use of objective measures for evaluating team performance. During data analysis responses were categorized per question.

Results

The findings from the 34 interviews revealed a predominantly positive reception of the idea of utilizing objective measures for evaluating team performance. However, the experts reported limited experience in actively incorporating objective measures into their training and research. Nevertheless, they identified various potential objective measures, including acoustical, visual, physiological, and endocrinological measures and a time layer. Concerns were raised regarding feasibility, complexity, cost, and privacy issues associated with the use of objective measures.

Discussion

The study highlights the opportunities and challenges associated with employing objective measures to assess healthcare team performance. It particularly emphasizes the concerns expressed by medical simulation experts and team researchers, providing valuable insights for developers, trainers, researchers, and healthcare professionals involved in the design, planning or utilization of objective measures in team training or research.
Evaluation of assistance systems allowing older drivers to intercept moving inter-vehicular space
Authors: Tran Van Lola , Berthelon Catherine , Navarro Jordan , Goulon Cédric , Mascret Nicolas , Montagne Gilles
Published: October 2023

Introduction

The objective of the present study was to test two Advanced Driving Assistance Systems (ADAS) designed to help older drivers to intercept a moving inter-vehicular space.

Method

Older and younger drivers were asked to intercept a moving inter-vehicular space within a train of vehicles in a driving simulator. Three ADAS conditions (No-ADAS, Head Down, Head Up) as well as five distinct speed regulation conditions were tested. Vehicle trajectory, gaze behavior and acceptance were analyzed.

Results

Our results reveal that the ADAS tested make it possible to perform the interception task but also to reduce the variability of the behavior produced. They also indicate that the location of the augmented information provided by the ADAS directly impacts the information-gathering strategy implemented. Finally, whereas younger divers reported mixed levels of ADAS acceptance, older drivers reported a good level of acceptance.

Discussion

All these results could be particularly useful with a view of designing ADAS for older drivers.
Interventions to reduce stress and prevent burnout in healthcare professionals supported by digital applications: a scoping review
Authors: Adam Daniela , Berschick Julia , Schiele Julia K. , Bogdanski Martin , Schröter Marleen , Steinmetz Melanie , Koch Anna K. , Sehouli Jalid , Reschke Sylvia , Stritter Wiebke , Kessler Christian S. , Seifert Georg
Published: October 2023

Aim

Healthcare professionals are at increased risk of burnout, primarily due to workplace-related stressors. The COVID-19 pandemic has further increased this risk. Different interventions exist with varying degrees of effectiveness; little is reported on the content and implementation of such programs. This review fills this gap, with attention to recent programs using digital components.

Methods

PubMed, Embase, PsycInfo, and Google Scholar were searched between January 24th and 28th, 2022, limited to the last 5 years (≥2017). Articles were included if they (1) focused on stress reduction or burnout prevention for nurses and medical doctors within workplace health promotion for nurses or medical doctors, (2) included a digital program component, (3) were conducted in high-income country contexts, and (4) were clinical studies published in English or German. Data was extracted using a priori designed spreadsheets. A group of at least 2 authors at each stage carried out the screening, selection, and data extraction.

Results

The search strategy identified 153 articles, all except 7 were excluded. Two studies were conducted in the USA, two in Spain, one in the Netherlands, Poland, and Korea each. Four studies used a randomized study design, all but one had a control group. A wide range of outcome measures was used. The types of interventions included an adapted mindfulness-based stress reduction program combined with aspects of behavioral therapies, cognitive behavioral therapy, or acceptance and commitment therapy. The digital components used were apps (4 studies), a digital platform, blended learning, and a web-based intervention (1 study each). Six studies focused on individual interventions, one included organizational interventions.

Conclusion

Despite an acute burnout crisis in the healthcare sector, only seven recent interventions were found that integrated digital components. Several problems emerged during the implementation of the interventions that made it clear that organizational support is urgently needed for successful implementation. Although interventions for stress reduction and burnout prevention should combine individual and organizational measures to be as successful as possible, this was only partially the case in one of the intervention programs. The results of this scoping review can be used to further develop or optimize stress and burnout prevention programs.
Assessment of the effects of NPK fertilizer on edible yield and agro-biological parameters in a cowpea–amaranth intercrop
Authors: Mndzebele Buhlebelive , Ncube Bhekumthetho , Fessehazion Melake , Mabhaudhi Tafadzwanashe , Modi Albert Thembinkosi
Published: October 2023

Introduction

Estimates indicate that food and nutritional demand in sub-Saharan African nutrient-poor soils will exceed the high population demand. Vegetables such as amaranth and cowpea are key in contributing to food and nutritional security. Fertilizers are used to mitigate low nutrient levels in soils. This study aimed to investigate the yield parameters of cowpea and amaranth vegetables.

Methods

The experiment was designed with a 2 × 4 factorial treatment structure in a completely randomized design, with intercropping and fertilizer level as treatment factors and with four replications.

Results and discussion

The biomass of amaranth and cowpea increased with increased fertilizer application up to the level of 100% nitrogen, phosphorus, and potassium (NPK) fertilizer. A measure of land utilization showed values greater than one. Crop comparison showed that cowpea was more aggressive, had higher actual yield loss, and was highly competitive compared to amaranth. More income could be obtained from intercropping. The research shows the benefits of fertilizer application in improving the biomass of amaranth and cowpea. Overall, the application of NPK fertilizer at levels up to 100%, based on the results of this study, resulted in higher biomass accumulation and improved intercropping indices.
Study on the Transition to True North in Air Navigation
Authors: Pleter Octavian Thor , Constantinescu Cristian Emil
Published: October 2023

The paper is an introductory study on the possible transition from Magnetic North reference to True North reference in air navigation, as envisaged by the International Association of Institutes of Navigation’s AHRTAG Group. The use of the Magnetic Field of the Earth as a direction reference in aviation is explained briefly. Magnetic North is an unstable and irregular directional reference that aviation manages well, but with significant costs. The unpredictability and uncertainties of the Magnetic Field of the Earth might be critical in the future, especially in the case of reversal of the magnetic poles, or incipient reversal. The paper puts forward the case for calculating the probability of such a catastrophic event, with a view to engaging further expert research in the geomagnetic phenomena. The purpose of such a probability estimate would be for the aviation decision makers to determine whether contingency planning might be required or not. Furthermore, the paper analyses the adoption of True North in maritime navigation as a possible model.
Special Issue on Rotor Dynamics: Theoretical Analysis, Computer and Experimental Modelling, Measurements
Authors: Zapoměl Jaroslav
Published: October 2023

Rotors and shafts are essential, often used, and highly loaded components of rotating machines and machine devices [...]
Modeling and Optimization of Processes for Craft Beer Production: Malt Mixture Modeling and Mashing Optimization for Lager Beer Production
Authors: Ivanov Alexander , Ivanova Kristina , Kostov Georgi
Published: October 2023

Beer ranks third in terms of consumption worldwide, and its technology is constantly being improved and perfected. The boom in craft brewing has led to the production of thousands of new types of beer, but most often without scientific justification of the technological decisions made. This paper discusses the approaches to the modeling of the composition of the malt mixture and the mode of lager beer production. A special cubic simplex-lattice design with two replications was used to model the mixture with three malt types: Pilsner, Caramel Pils and Caramel Munich type 2. Models for the main brewing characteristics, i.e., wort extract and color, as well as models for the biological parameters of the mash, i.e., phenolic compound content and antioxidant potential, were developed using different methods. Multi-objective optimization was carried out and a specific mixture was developed for the production of lager beer. The influence of acidulated malt, lactic acid and CaCl2 additions on the extract yield and malt mash filtration time were established through one-factor experiments. The extract and fermentable sugar yield during individual pauses in the mashing mode was studied with a view to its optimization.