bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathways of Targeted Therapy for Colorectal Cancer
Authors: Jain Sameeksha , Purohit Arpana , Nema Prakhar , Vishwakarma Harshna , Qureshi Arzoo , Jain Prateek kumar
Published: October 2022

One of the most common and deadly cancers in the world, colorectal cancer (CRC) caused around 881,000 melanoma deaths in 2018. The third most frequent cause overall cancer-related death worldwide is colorectal cancer (CRC). A difficult issue related to chemotherapy is the subsequent adverse effects brought on by the toxicity of conventional medications. Location-specific/targeted distribution of chemotherapeutic medicines precisely to the afflicted site of something like the colon in a foreseeable and reliable way is obviously of concern. For many years, cancer sufferers' initial choices have been surgery and chemotherapy. The prognosis for CRC, particularly for those with metastatic tumours, has never been satisfactory. A recent optional strategy called targeted therapy has been effective in extending patients with CRC's overall survival. Following achievements with the anti-EGFR (epidermal growth factor receptor) agent cetuximab and the anti-angiogenesis agent bevacizumab, new drugs that inhibit several important pathways and immune checkpoints are being developed at an unheard-of rate. The growing number of high-quality clinical trials is being used as a basis for updating guidelines worldwide regarding the recommended targeted medications. An overview of current CRC-targeted drugs and their underlying processes is given in this review, along with a discussion of their drawbacks and potential directions.

Keywords: Colorectal cancer, Chemotherapeutic medicines, Bevacizumab, Cetuximab,
A Review on Hot Melt Extrusion Coupled Novel Drug Delivery Systems
Authors: Parvathaneni Madhukiran , Heera Battu , Beeravelli Sudhakar
Published: October 2022

The utilization of hot melt extrusion (HME) technology for new applications is increasing in recent years, as evidenced by the many published reports in the last five years. Because of its process automation and low-cost scale-up qualities, which decrease labor expenses and capital investment. HME has emerged as an essential technology for drug delivery applications in pharmaceutical research and manufacture. The novel application of the HME process provides a promising alternate approach in the formulation of novel drug delivery systems. The present review discusses the importance of HME in the development of novel drug delivery systems with the review of relevant case studies.

Keywords: hot melt extrusion, novel drug delivery, pharmaceutical research
Saqmunia (Convolvulus scammonia L.), an important drug used in Unani system of medicine: A review
Authors: Ansari Huzaifa , Ansari Athar Parvez , Qayoom Ifra , Reshi Bazilah , Haseeb Abdul , Ahmed Zaheer , Anwar Noman
Published: October 2022

Background: Saqmunia, a resin obtained from the root of Convolvulus scammonia L. is widely used in Unani system of medicine for the treatment of several body ailments. This important medicinal plant is belonging to Convolvulaceae family, and is commonly grown in Mediterranean regions.

Purpose of the review: The core objective of this appraisal is to emphasize the different characteristics of Saqmunia (Convolvulus scammonia L.) viz. botanical description, pharmacological and therapeutic properties, folklore uses, temperament, dose, scientific studies, etc, as mentioned in Unani and botanical literature that will be helpful in the rationale use of this botanical drug.

Materials and methods: This review was done after going through ample of literature survey of Unani and botanical texts, and published articles related to Saqmunia (Convolvulus scammonia L.). The botanical names of drugs mentioned in this review have been validated through ‘World Flora’ (http://www.worldfloraonline.org).

Results: The Unani physicians prescribe Saqmunia for the treatment of skin diseases, chronic headache, bilious fever, conjunctivitis, jaundice, etc. This drug is also added in many compound Unani formulations such as Habb-i-Kotwali, Safoof-i-Suranjan, Habb-i-Banafsha, Ayarij-i-Kabir, Tiryaq-i-Zahab, Habb-i-Saqmunia, Majun-i-Anjeer, etc which are used for various therapeutic purposes. The phytochemical analysis of the root of Convolvulus scammonia L. has been reported that it contains 8% resin along with beta-methyl-esculetin, dihydroxy cinnamic acid, ipuranol, sucrose, reducing sugar, starch, etc. The resin yields glycosides mainly scamonin which is pharmacologically active. Some scientific reports showed that this important medicinal plant possesses certain potential pharmacological activities. The significant anticancer property of aqueous and alkaline extracts of Convolvulus scammonia L. has been identified in mice.

Conclusion: Although, the resin of Convolvulus scammonia L. is extensively used in Unani medicine. But, sufficient studies regarding its pharmacognosy, phytochemistry, pharmacology and toxicology are still lacking. Hence, it is suggested that extensive studies by using modern scientific parameters may be carried out to explore the every aspect of this important botanical drug.

Keywords: Saqmunia; Convolvulus scammonia L.; Unani medicine; Resin
Hic et nunc: what is the conception of development when addressing regional development?
Authors: Theis Ivo Marcos
Published: October 2022

This article aims to assess the meanings of the notion of development that have been applied in analyses on ‘regional development’ in Brazil, considering the scope of action of the postgraduate programs linked to this field of knowledge. In methodological terms, the roots of the notion of development are reappraised, some of the meanings that it has assumed along its trajectory are examined and some critiques of development are reviewed, thereby bringing a number of alternatives to the surface. The conclusion is that the notion of development has been unable to pave the way in overcoming the existing reality. Hence, a proposal is postulated that transcends (empirically, theoretically and politically) the protagonism of capital and of the State, and contemplates a social transformation from the bottom-up, based on a drive toward social self-determination.
Relación entre empatía, compasión y Burnout en estudiantes de medicina, residentes y profesionales médicos de Medellín
Authors: Suárez Cadavid Elena , Lemos Mariantonia , Ruiz González Erika Patricia , Krikorian Alicia
Published: October 2022

Los médicos están expuestos a altos niveles de presión laboral, lo que conduce a un mayor riesgo de Burnout. La empatía es el reconocimiento cognitivo y afectivo del estado de ánimo y situación de una persona. La compasión es una respuesta al reconocimiento del sufrimiento del paciente y al deseo de reducirlo. Objetivos: explorar la relación entre empatía, compasión y Burnout en estudiantes y profesionales médicos y otras variables relacionadas con el síndrome. Método: 143 médicos y estudiantes respondieron un cuestionario sociodemográfico, el MBI, el TECA y la Escala de Compromiso y Acción Compasivos. Resultados: el 41,9 % mostró altos niveles de agotamiento emocional, el 21 % despersonalización y el 19,5 % bajos niveles de realización personal. Los niveles de Burnout se asociaron negativamente con la percepción de equilibrio entre la vida social, familiar y laboral, la compasión y la edad; F(5, 92) = 11,012, p < 0,00; (p < 0,05). La fatiga emocional interrumpió el desarrollo de comportamientos relacionados con la autocompasión y disminuyó la percepción de éxito. Conclusiones: para que los médicos tengan niveles óptimos de empatía afectiva y compasión, es fundamental el desarrollo de empatía cognitiva y habilidades de regulación emocional. Estos son factores protectores de Burnout.
Analysis of water source contribution and its impact on hydrological structural connectivity in urban plain river network area based on stable isotopes
Authors: Zhang Shuiling , Bu Jiuhe , Li Chunhui , Xiangen Xu , Wang Xuan , Liu Qiang
Published: October 2022

Water sources carry chemicals that can have a significant impact on the
water environment of a river network, and understanding the contribution
of different water sources to the river network can help to manage the
pollution of the river network at its source. Hydrological connectivity
of a river network affects the self-purification capacity and flood
prevention capacity of the river. Thus an isotope tracer approach was
applied to figure out the contribution rate of different water bodies to
a river network and hydrological connectivity was quantified by
introducing retention rate. Changzhou city was selected as the study
area because it is an urbanized city with the characteristics of plain
river network and it is faced with poor hydrological connectivity due to
artificial constructions (dams and pumps) and human activity
(urbanization). River water, well water (shallow groundwater), lake
water and rainfall were collected during the flood season and nonflood
season, and hydrogen and oxygen isotopes were determined. The temporal
and spatial variations in hydrogen and oxygen isotopes in different
water bodies and the state of the water cycle in different water bodies
were analyzed. IsoSource and MixSIAR models were established to analyze
the contribution rate of river network water sources in the study area,
and their effectiveness was compared. Results of MixSIAR model were
selected to evaluate the hydrological connectivity of the river network
in the study area, providing a method to quantify the hydrological
connectivity of specific river of the river network in Changzhou. This
method could also be applied to other urban plain river network area to
study its river connectivity.
The ultrasound outcomes of a pregnant female undergoing a double anticoagulant regimen due to suspected mechanical valve thrombosis: a case report and a literature review
Authors: Bai Chunqiang , Wu Haiying , Wenying Wu , Feng Peiming , Nie Minghui , Zhao Li , Meng Fanyue
Published: October 2022

Most previous treatment guidelines for pregnant women with mechanical
heart valves (MHVs) recommended that low molecular weight heparin (LMWH)
should be applied once every 12 hours and only as required to reach peak
anti-Xa levels of around 1.0–1.2 IU/mL,but it is commonly associated
with and subtherapeutic trough levels consequently with an inadequate
level of anticoagulation. Our case report here together with a
literature review suggests that dose-adjusted (Target trough anti-Xa
levels of 0.6-0.7 IU/mL and with peak anti-Xa levels of around 1.0–1.2
IU/mL or less than 1.5 IU/mL) LMWH should be given thrice daily
throughout pregnancy.In addition, the findings of this rare case
indicate that a combination of LMWH and warfarin is effective in the
treatment of small thromboses in pregnancy.
Erythema multiforme-like bullous pemphigoid following COVID-19 mRNA vaccine
Authors: Ghannem Azza , Rabhi Faten , Gargouri Faten , Jaber Kahena , Dhaoui Raouf
Published: October 2022

Cases of bullous pemphigoid following Covid-19 vaccines have been
recently reported. We describe herein an atypical case of acral bullous
pemphigoid after Pfizer BionTech vaccine. Clinicians should be aware of
this reaction and encourage full vaccination as the disease displays a
rapid improvement treatment.
Qilong capsule alleviates ponatinib-induced ischemic stroke in a zebrafish model by regulating coagulation, inflammation, and apoptosis
Authors: Lin Shenghua , Liu Xin , Sun Aonan , Liang Huiliang , Li Zhen , Ye Suyan , Ma Honglin , Fan Wei , Shen Chuanlin , Jin Meng , He Qiuxia
Published: October 2022

Background: Qilong capsule (QLC) is a traditional Chinese medicine
commonly used to treat ischemic stroke (IS). But the pharmacodynamic
mechanism of QLC is not clear. Method: we used an existing zebrafish
model to explore the protective mechanism of QLC on IS. We treated
normally-developing zebrafish larvae with QLC and ponatinib 2 days post
fertilization, and used the area of cerebral vascular thrombosis, red
blood cell staining intensity, and brain cell apoptosis to quantitate
QLC efficacy against IS. Real-time quantitative polymerase chain
reaction (qPCR) was used to detect changes in the expression of genes
involved in coagulation, inflammation, vascular endothelium, and
apoptosis. Result: We found that QLC reduced the area affected by
ponatinib-induced cerebral vascular embolism, erythrocyte staining
intensity, and the number of apoptotic brain cells. qPCR showed that QLC
inhibited the expression of genes related to coagulation, inflammation,
and apoptosis. Conclusion: QLC had a significant protective efficacy in
ponatinib-induced IS.
Using Administrative Healthcare Data to Identify Drug Repurposing Opportunities: The Example of Beta-blockers as Breast Cancer Treatment
Authors: Tan George , Botteri E , Wood Stephen , Sloan Erica , Ilomaki Jenni
Published: October 2022

Aim: Cancer registries and hospital medical records are commonly used to
investigate drug repurposing candidates for cancer. We aimed to evaluate
a drug repurposing opportunity in cancer using administrative data by
analysing the association between beta-blocker use and breast cancer
survival. Methods: A retrospective cohort study of women aged ≥50 years
with incident breast cancer was conducted using a linked dataset with
state-wide hospital admission data and nationwide medication claims
data. Women receiving beta blockers and first-line anti-hypertensives
were compared. Breast cancer molecular subtypes and metastasis status
were inferred by algorithm from commonly prescribed breast cancer
antineoplastics and hospitalization diagnosis codes, respectively.
Subdistribution hazards for breast cancer mortality were estimated using
Fine and Gray’s competing risk models adjusted for age, Charlson
comorbidity index, congestive heart failure, molecular subtype,
metastasis, and breast cancer surgery. Results: 2758 women were
hospitalized for incident breast cancer; 604 received beta-blockers and
1387 received first-line antihypertensives. In total, 185 breast cancer
deaths were identified over a median follow-up time of 2.6 years. We
found no significant association between any beta-blocker use and
breast-cancer mortality (sHR 0.85, 95%CI 0.57-1.28), or when stratified
by beta-blocker type (nonselective, sHR 0.67, 95%CI 0.24-1.81;
selective, sHR 1.06, 95%CI 0.74-1.54). Conclusions: We show that it is
possible to use administrative data to investigate drug repurposing
opportunities for cancer. However, we did not find an association
between beta-blocker use and breast cancer survival, likely due to small
sample size and short follow-up. Further studies are required to confirm
the association.
Controlling nozzle and kerf gas dynamics to manage hazardous laser cutting fume
Authors: Lavin Jacob J. , Jones Mathew T. , Long Edward J. , Tyrer John R. , Spencer Julian T. , Dodds Jonathan M. , Jones Lewis C. R.
Published: October 2022

Conventional laser cutting is optimized for cut speed and quality but does not consider process fume. When processing hazardous materials in environments where global extraction is not practical, such as during in situ nuclear decommissioning, consideration of process fume is critically important. Fume generation in laser cutting is governed by forces applied to the molten cut front; dynamic interactions between the assist-gas and the cut front control these forces. This paper investigates the causal links between key gas-dynamic features and fume generation mechanisms in laser cutting. Its aim is to provide the preliminary understanding required to design process setups targeted at reducing the fine particle fraction. During laser cutting, the assist-gas boundary layer separates (BLS) from the molten cut front and, therefore, downstream forces applied on the melt are significantly changed. In this work, the BLS point is analyzed, captured via schlieren imaging, in an idealized environment. This separation point is related to features on the cut wall of laser-cut samples, validating the gas-dynamic interactions. The samples were cut from 3 mm thick 304 stainless steel, using a 1 kW Nd:Yb fiber laser. Control of the surface stagnation pressure and gas flow boundary conditions were used to relocate the point of BLS within the cut front, and the relationship of these parameters was analyzed. The results demonstrate that shifting the point of BLS along the cut front can be used to control fume generation mechanisms. This study successfully provided the preliminary understanding necessary to manage fume generation during the laser cutting process.
Muhammad Asad dan Telaahnya terhadap Hadits dan Sejarahnya
Authors: Amir Ahmad Nabil , Marzuki Zunaidah Mohd.
Published: October 2022

Artikel ini menyorot pemikiran hadith Muhammad Asad (1990-1992) dan kontribusinya dalam pemahaman hadith kontemporer. Penelitian ini dibuat berlatarkan premis yang mengandaikan tentang pengaruh hadith yang mendasar dalam pemikiran Asad. Karyanya membuktikan keyakinan ini, iaitu dari terjemahan dan syarahnya ke atas kitab Sahih al-Bukhari yang memperlihatkan pengaruh yang signifikan dari prinsip dan tradisi hadith terhadap pemikiran dan keyakinan intelektualnya. Berangkat dari premis ini, tulisan ini cuba membincangkan pemahaman asas tentang hadith yang dirumuskan dalam karya-karyanya seperti Sahih al-Bukhari The Early Years of Islam;Islam at The Crossroads (bab “Hadith and Sunnah” dan “The Spirit ofthe Sunnah”);This Law of Ours and Other Essays; The Road to Mecca dan The Message of the Qur’an. Pengaruh hadith ini bisa dilihat dalam jurnal Arafat dan makalahnya yang lain terkait tema-tema hadith dan sunnah dan pemahamannya di abad moden, seperti tulisannya “Social and Cultural Realities of the Sunnah”. Metode penelitian adalah bersifat deskriptif, analitis, historis dan komparatif. Penelitian ini mengembangkan ide dan fikrah hadith yang dirumuskan Asad dari perspektifnya yang moden dan membandingkannya dengan pemikiran-pemikiran sejarah yang krusial terkait prinsip hadith yang dibawakan oleh pemikir Islam yang lain. Penelitian ini menyimpulkan bahawa Muhammad Asad telah memberikan sumbangan yang penting dalam pemikiran hadith di abad moden dengan hasil penulisannya yang prolifik, terutama terjemahan dan syarahannya yang ekstensif terhadap Sahih al-Bukhari yang memuatkan komentar-komentar yang baru dan analisis sejarahnya yang substantif terhadap kitab ini. Hasil penelitian membuktikan yang Asad telah membawa pemahaman yang signifikan tentang tradisi hadith dan mengusung nilai dan semangatnya yang asli menurut kefahamannya yang sebenar dari pengalaman awal Islam. Ia turut merumuskan pertentangan-pertentangan hukum dan dasar yang diambil dalam istinbat-istinbat fuqaha dan muhaddith dalam tradisi syarah hadith yang kritis. Beliau turut merespon pertikaian-pertikaian asas yang dibangkitkan oleh golongan orientalis dan intelektual yang skeptis terhadap riwayat-riwayat sejarah dalam tradisi hadith.
Drop-Out School Phenomenon from Social Perspective at Gunung Batu Village, Pulau Beringin Sub-District, South Oku District
Authors: Handayani Wiwik , Shomedran Shomedran
Published: October 2022

This study aims to study amd explain the phenomenon of School Dropout seen from the Social Aspects in Gunung Batu Village, Pulau Beringin District. This study uses a descriptive method with a qualitative approach. The informants in this study may be five people. The data technique used was interview research subjects. The data analysis techniques used were data, data reduction, data presentation, and data retrieval. Based on the results of data analysis carried out through the triangulation method, it can be concluded that the phenomenon of children dropping out of school is seen from social aspects, social aspects of society and aspects of children's social behavior. Social aspects of society, namely children dropping out of school are more concerned with working as farmers to earn their own money to continue their education, aspects of social behavior of children dropping out of school besides working to earn their own money, dropping out children also do habits in the community, namely playing, hanging out on the roadside, sports and gather with friends in the community.Key words: children, droping out of school, social aspe
Relationship of Family Education with The Independency of Children at Age 5-6 years
Authors: Aulia Intan , Syur’aini Syur’aini
Published: October 2022

This research is motivated by the low independence of children aged 5-6 years in the Jihad Indah Persada 2 Housing Complex, Padang City, which is suspected to have something to do with family education. The purpose of this study was to reveal a description of family education, the independence of children aged 5-6 years in the Jihad Indah Persada 2 Housing Complex, Padang City, and to reveal the relationship between family education and the independence of children aged 5-6 years in the Jihad Indah Persada 2 Housing Complex 2 Cities. field. This type of research is a descriptive correlational research with a quantitative approach. The population of this study is parents who have children aged 5-6 years in the Jihad Indah Persada 2 Housing Complex, Padang City, totaling 50 people and a sample of 75%, namely 37 people with a sampling technique that is srtatified random sampling. The data collection technique used is a questionnaire and the tool used is a questionnaire. The data analysis technique uses the percentage formula and the product moment formula. The results of this study indicate that: 1) family education in the Jihad Indah Persada 2 Housing Complex in Padang City is low; 2) the independence of children aged 5-6 years in the Jihad Indah Persada 2 Housing Complex in Padang City is low; 3) There is a significant relationship between family education and the independence of children aged 5-6 years in the Jihad Indah Persada 2 Housing Complex, Padang City. Keywords: Family Education, Child Independence
The Effectiveness of Pre-Marriage Education Program toward the Mental Readiness of Adolescent in Mekarwangi Residence
Authors: Nurfachriyah Haniroh , Alendra Yusiyaka Rahmi
Published: October 2022

Individual readiness and maturity is a must-have for someone who is going to get married. For this reason, the Ministry of Religion is instructed that every prospective bride and groom who will marry must first follow marriage guidance as a step in realizing a sakinah, mawaddah and rahmah family. This research is a field research with a normative-empirical legal research method. This research was conducted at the Bukit Mekarwangi Housing Estate, Tanah Sareal District, Bogor City. Primary data sources are taken from interviews with parents of adolescents and adolescents themselves. Secondary data sources are collected through legal sources, implementation documents, modules and other supporting data. Furthermore, the data were analyzed descriptively. Based on the results of the research conducted, the researchers concluded that: first, pre-marital marriage guidance in Bukit Mekarwangi Housing was in accordance with the technical instructions for implementing marriage guidance. Implementation of the guidance can be said to be effective seen from the organization of activities and the fulfillment of infrastructure at the research site. In addition, it also has a positive impact on the bride and groom. Second, the effect of implementation on the readiness of the bride and groom: mentally and conceptually related to their marriage increases with the increase in new knowledge they get from the material presented.Keywords: Teenagers, Premarital, Counseling
Dialog and evangelization according to Charles de Foucauld and The Implication for the Church of Indonesia
Authors: Kristiyanto Materius
Published: October 2022

This qualitative research uses a literature review method with the aim of exploring Charles de Foucauld's thoughts on dialogue and evangelization among Muslims. The ideas of dialogue and evangelization can be traced from his life story as a Catholic priest and missionary. His spiritual life was colored by seeking the last place, as Jesus lived in Nazareth, in several Trappist monasteries, and finally chose to become a missionary priest. He became a missionary in Algeria in preparation for a mission to Morocco. He lived among the Muslims in Beni Abbs - Tuaregh and Tamanrasset. He built a house of brotherhood to build brotherhood with everyone. He testifies to a simple and ascetic life. After Foucauld's death, several groups of followers grew in Europe, namely Piccoli Fratelli and Piccole Sorelle. They form small communities that continue the spirit of dialogue and evangelization by living as a unit in society in the form of an inclusive basic community. The basic community aims to build universal brotherhood, regardless of ethnicity, religion, and race. The inclusive dialogue model is very relevant for the multicultural and multireligious Indonesian society.
The Dichotomy Between Tabarru’ and Mu’âwaḍah Contracts: Perspective of Indonesian Law of Obligation
Authors: Aziz Jamal Abdul , Uswatusolihah Uus
Published: October 2022

Among many divisions of contract (‘aqd) in mu’âmalah shar’iyyah, the dichotomy between tabarru’ and mu’âwaḍah contracts is the most influential paradigm in getting to know the jungle of classical and contemporary mu’âmalah contracts. Tabarru’ contract (tabarru’ât) means contracts of virtue as if it should be free from material self-interest or any other profane benefit. Meanwhile, mu’âwaḍah contract (mu’âwaḍât) means business contracts as if it is laden with material calculation and other various forms of self-interest. The dichotomic paradigm of these contracts is quite urgent that it is often made the ground to determine whether or not some material benefit obtained from certain contracts is allowed. It is interesting to observe, that the Indonesian law of obligation which is originating from a Dutch colonial legacy actually also acknowledges such a contract. It is, however, not as strict as its divisions in Islamic fiqh.
СИСТЕМА АНАЛИТИЧЕСКИХ АЛГОРИТМОВ ЦИФРОВОЙ ТРАНСФОРМАЦИИ ДАННЫХ ЭКОЛОГИЧЕСКОГО МОНИТОРИНГА
Authors: Иванов Дмитрий Владимирович , Валиев Всеволод Сергеевич , Шамаев Денис Евгеньевич , Хасанов Рустам Равилевич
Published: October 2022

В статье представлена система цифровой трансформации данных мониторинга, позволяющая автоматически рассчитывать удельные комбинаторные индексы загрязненности воды и донных отложений водных объектов и получать их обобщенные оценки с указанием приоритетных загрязнителей и наиболее загрязненных сред. Результаты исследования направлены на обеспечение внедрения в систему экологического мониторинга современных алгоритмов обработки непрерывных потоков данных о содержании загрязняющих веществ в окружающей среде.

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Шагидуллин Р.Р., Латыпова В.З., Тарасов О.Ю., Никитин О.В., Яковлева О.Г., Иванов Д.В., Петров А.М., Шагидуллина Р.А., Крапивина Н.Ю., Юранец-Лужаева Р.Ч. Природные и антропогенные факторы формирования качества воды озера Средний Кабан г. Казани // Георесурсы. 2012. №7(49). С. 11‒17.
Ekstraksi Tanin dari Limbah Kulit Biji Asam dan Penggunaannya Sebagai Biomordan pada Pewarnaan Tenun Timor Secara Alami
Authors: Adu Risna Erni Yati , Djue Tea Marselina Theresia , Yunita Bouk
Published: October 2022

Tannins from tamarind seed husk were extracted and applied as a biomordant for natural dyeing process of Timor woven fabrics. Tannins were extracted using hot distilled water, qualitatively and quantitatively analyzed and applied as a color binder to the woven fabrics. The color characteristics of woven fabrics with tannins were compared to the woven fabrics that mordanted with Al2(SO4)3 and FeSO4 at the concentration of 15%. Tamarind seed husk tannins are in the form of a brownish red powder. Qualitative and quantitative tests showed that tamarind seed coat contained condensed tannins with a total concentration of 70.08 ± 0.14%. Tannins identification by FT-IR spectroscopy showed a strong band absorption at 3369 cm-1 for O-H group and a weak absorption at 1721 cm-1 due to the C=O stretch. A strong absorption at 1611-1608 cm-1 was observed for C=C group in the aromatic ring and was strengthened with a strong absorption at 1520 cm-1, C-O-C group which is specific for condensed tannins was observed at 1285 cm-1. Application of 15% tannin as a biomordant without natural dye on Timor woven fabric produced a brownish red color, while the use of 15% tannin and turmeric dye showed a brownish yellow color. Tannin exhibited a better color fastness than metalic mordants in natural dyeing of Timor woven fabrics.
Una exploración a la dinámica empresarial en Quibdó, Departamento del Chocó, 1950-2010
Authors: Uribe Castro Hernando , Sabogal Pinilla José Reinaldo , Aristizábal Giraldo Juan Carlos
Published: October 2022

La Región Pacífica encierra una de las mayores riquezas con que cuenta nuestro país: el departamento del Chocó. Es el único con costas en el Océano Pacífico y en el Atlántico; por su territorio fluyen dos de los ríos más importantes de Colombia: el Atrato y el San Juan; además, es atravesado de sur a norte por la cordillera Occidental. Su territorio alberga una de las mayores riquezas en fauna, flora, recursos minerales y reservas hídricas, que le permiten entrar al siglo XXI como una potencia mundial si se explotan con responsabilidad y se canalizan esas ganancias hacia el desarrollo social de la región. Sin embargo, el principal activo es su gente, su cultura, su alegría y el talento humano que, aunado a políticas educativas de desarrollo empresarial, respeto al medio ambiente y distribución de la riqueza, conllevarán al desarrollo socioeconómico del departamento hacia finales del año 2019, con miras a alcanzar los estándares nacionales de competitividad y de calidad de vida.
"أثر استراتيجية تنشيط المعرفة السابقة في تنمية التفكير فوق المعرفي لدى طلاب الصف الثاني المتوسط في مادة التاريخ"
Authors: Al-Zubaidi Raad Khalaf Muhammad , Fayyad Motamad Saleh
Published: October 2022

أجريت هذه الدراسة في العراق  / محافظة صلاح الدين/ ناحية الضلوعية, وترمي إلى تعرف أثر استراتيجية تنشيط المعرفة السابقة في تنمية التفكير فوق المعرفي لدى طلاب الصف الثاني المتوسط في مادة التاريخ , ولتحقق لهدف البحث استعمل الباحث المنهج التجريبي لبحثهِ لأنه أكثر ملاءمة لهذا النوع من البحوث, وتم التأكد من تكافؤ المجموعتين , تكونت عينة البحث من (64) طالباً , موزعه بواقع (31) طالباً للمجموعة التجريبية , و (33) طالباً للمجموعة الضابطة , وقام الباحث بتدريس المجموعتين الموضوعات التي حُددت مسبقاً, وقد اعد الباحث مقياساً للتفكير فوق المعرفي الذي يقيس مستوى الطلاب في مادة التاريخ , وتم التحقق من صدق وثبات الاداة , واستعمل الباحث اختبار (t – test) ومربع كاي ومعامل ارتباط بيرسون لمعالجة البيانات, وبعد تطبيق الاختبار على مجموعتي البحث, وأظهرت النتائج تفوق طلاب المجموعة التجريبية الذي درسوا باستعمال استراتيجية تنشيط المعرفة السابقة على طلاب المجموعة الضابطة الذين درسوا بالطريقة الاعتيادية في التفكير فوق المعرفي في مادة التاريخ على المجموعة الضابطة, مما يؤكد أنّ تدريس مادة التاريخ  للصف الثاني المتوسط باستعمال استراتيجية تنشيط المعرفة السابقة أكثر أثراً من تدريسها بالطريقة الاعتيادية في التفكير فوق المعرفي.
تثنية التغليب في كتاب (الدر النقي في شرح ألفاظ الخرقي) لابن المبرد (ت909هـ)
Authors: Mahmoud Hussein Nouri , Taha Hassan Ali , Abdul-Mahdi Kamel Musab Talib
Published: October 2022

بسم الله, والحمد لله, والصلاة والسلام على خير خلق الله محمد - صلى الله عليه وسلم - وعلى اله وصحبه ومن والاه.
   إن الذي دعانا إلى دراسة ظاهرة (تثنية التغليب) هو ان هذه الظاهرة تُعَدُّ من جملة الظواهر الدلالية التي تضاف إلى وسائل نمو واثراء اللغة العربية بالمفردات, ولأن استعمال مفردات ظاهرة (تثنية التغليب) في معانيها المتعارف عليها هو استعمال مجازي؛ لأنه تعبير عن المعاني بغير ما وضع له في اصل اللغة, كإطلاق لفظة (القمرين) عَلَى الشمس والقمر, فدلالتها عَلَى الشمس من باب المجاز؛ لأنه تعبير عنها بغير ما وضع لها من لفظ في اصل اللغة, كما ان بعض هذه ‌الألفاظ ‌المثنّاة من باب التغليب قد تنوعت مدلولاتها وتعددت, ولسياق الكلام دور في تحديد المدلول المراد منها كما سياتي معنا في لفظة (الاسودين), وقد ‌أَوْلَى ابن المبرد لألفاظ هذه الظاهرة أهمية بارزة في كتابه (الدر النقي في شرح الفاظ الخرقي), وضرب لها من الامثلة ما يوضح المراد بها, كما أن لتغليب احد الاسمين على الاخر معايير متبعة لدى العرب, ذكرنا منها ما ورد في الامثلة المدروسة لدينا, ومن ذلك تغليبهم الْمُذَكَّرِ عَلَى المؤنث والْعَاقِلُ عَلَى غَيْرِ العاقل, والْأَكْثَرُ عَلَى الْأَقَلِّ, وتَغْلِيبُ الأشهر عَلَى ما دُوْنِهِ, الى غيرها من المعايير.
الفنون اللفظيّة في شعر الموحدين الاندلسيّين (التكرار ورد العجز على الصدر ولزوم ما لا يلزم أنموذجاً)
Authors: Youssef Jomaa Hussein , Hussein Khalaf Abdulwahab , Al-Hadithi Maha Tawfiq Yousif
Published: October 2022

يعد التكرار فنّاً أساسياً, يُرد إليه عدد من الفنون البديعية, كرد العجز على الصدر, ولزوم ما لا يلزم في دراستنا, وقد حاولنا في التكرار دراستهِ على المستويات كلها, وحاولنا في دراسة رد العجز على الصدر, تأكيد الأهمية الموقعية في هذا الفن,  وفي لزوم ما لا يلزم، فقد آثرنا دراسته من خلال المجموعات الشعرية للموحدين الأندلسيين, للخروج بصورة علمية وصحيحة عن هذا الفن البديعي في شعر الموحدين الأندلسيين, فتتبعنا صوره وأشكاله ومظاهره وأثره في النصوص الشعرية.
التمثيل الخرائطي لتغير حدود المحافظات العراقية للفترات (1921-1959-2019) _ (بغداد، كركوك) انموذجاً
Authors: Jassim Al Douri Sadiq of Mustafa , Shaker Baha Sahib
Published: October 2022

يركز البحث الموسوم (التمثيل الخرائطي لتغير حدود المحافظات العراقية للفترات (1921-1959-2019) _ (بغداد، كركوك) انموذجاً على تغير حدود المحافظات المذكورة انفاً تاريخياً للأعوام 1921 ، 1959، 2019 و نشأة الحدود الادارية لها والعوامل المؤثرة في تشكيل الحدود سواء كانت طبيعية او بشرية، ومن ثم دراسة الوحدات الادارية التابعة لكل لواء او المحافظة واجمالي عدد سكانه زمانياً، وعكفت الدراسة على التأكيد على نمذجة التغير المكاني لمساحة المحافظات بدءاً من عام 1921 على ثلاث مراحل وهي (1921، 1959، 2019 وتمثيلها لمعرفة معدل التغير واتجاهه.    تمثلت منطقة الدراسة بالمحافظات العراقية (بغداد، كركوك) وهي نماذج مختارة من العراق.    اما الحدود الزمانية للدراسة فقد تم حصرها بين عام 1921 الى 2019، كونها المدة التي تتوفر بها خرائط اساسية للمنطقة اولاً وهي من اكثر الفترات التي شهدت تغيراً في الحدود الادارية ثانياً.      وتوصلت الدراسة الى ان العراق بشكل عام والمحافظات المعنية بالدراسة بشكل خاص قد شهدت تطوراً كبيراً في حدود محافظاته الداخلية وهذا ناتج عن زيادة ونمو عدد سكانه. ثم عكفت الى انشاء اطلس لتغير حدود المحافظات العراقية كخطوة اساسية تعتمد عليها الدراسات التي تليها، والاستفادة منها في الدراسات التاريخية التي تركز عليها الجغرافية التاريخية.    تعد التقنيات الحديثة بأنظمة المعلومات وبيانات الاستشعار عن بعد من أنجح الطرق في بناء النماذج التي تحاكي تغير حدود المحافظات العراقية لأنها تعبر عن التغير المكاني والزماني.
Integrasi Learning Manangement System
Authors: Sumiah Aah , Bahtiar Rian
Published: October 2022

Perkembangan teknologi khususnya di bidang teknologi informasi (khususnya internet) mampu mengubah gaya hidup (khususnya masyarakat pengguna internet). Beberapa permasalahan yang diakibatkan oleh keterbatasan kondisi karena kondisi geografis dapat dihadapi oleh internet untuk melakukan komunikasi. Proses pembelajaran umumnya hanya terjadi di dalam kelas. Sekarang hari, itu bisa dilakukan secara online dengan menggunakan internet. E-learning dengan Learning Management System (LMS) dapat membantu proses pembelajaran yang dikembangkan dengan menggunakan bahasa pemograman PHP dan bahasa pemograman berbasis Android dengan menggunakan ANDROIDSDK sebagai library dan MySQL sebagai databasenya. untuk menghubungkan sistem E-learning dengan aplikasi seluler sebagai sistem yang terintegrasi. Metode pendekatan yang digunakan adalah OOP (Object Oriented Programming), sehingga arsitektur programnya menggunakan konsep UML (Unified Modeling Language). Dengan aplikasi m-learning Berbasis Android, pengguna dapat menggunakan e-learning melalui aplikasi mobile berbasis android, karena sebagian besar aplikasi e-learning tertanam dengan aplikasi mobile berbasis android. Pengguna juga dapat melihat tugas mahasiswa, nilai, dan materi yang diberikan oleh dosen pengguna, materi berupa file yang harus diunduh. Sistem ini diharapkan dapat meningkatkan minat pengguna terhadap e-learning.Kata kunci: E-learning, M-learning, Android, UML, Integrasi, LMS
Sistem Informasi Produk Unggulan Desa Kecamatan Cibingbin Berbasis Web dengan Menggunakan PHP dan MYSQL
Authors: Fauziah Fauziah
Published: October 2022

The supreme products are the ones produced by the Village people which havehigh chances to be marketed and sold and are thus advantageous for them thisthesis which is entitled “: Information System Vilage Superior Product AtDistrict Of Cibingbin Based On Website, Use PHP And MySQL” is a mediafor marketing and selling the Village’s supreme products in the District ofCibingbin. Besides that, by the the existence of a website in the District ofCibingbin, the local officials in the District and Villages of Cibingbin can makethe news related to their regions. The input process of those product are conductedby the Village and the District’s parts. The next process of product selling isconducted by the District’s part. There are three parts who have the right to accessthe website in the District of Cibingbin, namely the District, the Villages and theCustomers
Penerapan Customer Relationship Management Analitycal Menggunakan Query analyzer pada penjualan berbasis Online
Authors: Irawan Dede , Merdekawati Putri Maulin
Published: October 2022

Kehadiran teknologi berbasis komputer diberbagai bidang sangat banyak memberikan kemudahan yang berarti. Sehingga setiap kegiatan yang berhubungan dengan jalannya usaha akan lebih cepat dan tepat. OutVin Store merupakan toko online yang menjual segala jenis fashion wanita yang penjulannya masih melalui aplikasi BBM sehingga pembelian dan penjualan terbatas serta penyimpanan data yang masih manual menuntut untuk dirancang dan dibuatkan toko online berbasis website dan penyimpanan data yang terkomputerisasi. Oleh karena itu diperlukan suatu sistem komputerisasi yang dapat menanggulangi proses penjualan dan pembelian serta penyimpanan data sehingga penjualan dan pembelian bisa mencakup wilayah yang lebih luas serta data lebih aman. Maka digunakan metode customer relationship management yaitu manajemen hubungan pelanggan yang mengatur dan mencari cara bagaimana agar bisa memuaskan konsumen sehingga konsumen lebih luas dan menerapkannya ke website yang bisa membuat proses jual beli lebih luas. Sistem dirancang dengan menggunakan diagam konteks, flowmap, DFD level 0, DFD level 1 dan ERD. Sistem ini mengelola data barang, data jual beli, dan data konsumen. Di dalam sistem, CRM Analitycal diterapkan dalam laporan order, lapoan fashion mana yang paling banyak dibeli, laporan wilayah yang paling banyak melakukan transaksi dan laporan konsumen mana saja yang paling banyak melakukan transaksi. Hasil perancangan diimplementasikan ke dalam bahasa pemrograman PHP dan MySQL. Sistem ini dapat memudahkan konsumen untuk berbelanja barang-barang di OutVin Store serta memudahkan pemiliknya untuk menyimpan dan mengolah data-data yang ada.Kata kunci : Customer Relationship Management, Customer Relationship Management Analatycal Teknologi, Penerapan, Manajemen Hubungan Pelanggan, Sistem Informasi.
Corruption in the allocation of resources in a static model of a combination of general and private interests
Authors: Gorbaneva Olga Ivanovna
Published: October 2022

The article is devoted to the study of corruption in the previously studied static model of the combination of common and private interests (SOCHI model) of several agents, namely, corruption in the allocation of resources. The upper level – the principal – allocates resources to the elements of the lower level - agents - so that the latter distribute them between their general and their private interests. The middle level - the supervisor representing the interests of the top level - underestimates the amount of resources allocated to the agent, which he can increase by a certain amount, but no more than to the level initially set by the principal. A three-level hierarchical tree system is formed. This article examines a three-level hierarchical system in which the supervisor uses an economic corruption mechanism in the allocation of resources. Two approaches are used in the study of this mechanism: descriptive and optimization. The descriptive approach assumes that the functions of bribery in question are known. The optimization approach involves the use of Hermeyer's theorem. The influence of corruption in the allocation of resources on system consistency in the SOCHI model is investigated: it is proved that corruption in the allocation of resources can only reduce consistency in the SOCHI model. It is proved that economic corruption is always beneficial for agents, but it turns out to be manipulative for a supervisor. The only way to fight corruption in the allocation of resources has been found.
The Problem of Interaction Between the Ministry of Internal Affairs of Russia and the Ministry of Emergency Situations of Russia During Inspections on Fires
Authors: Sushkin Nikolai Vladimirovich , Azovtsev Egor Mikhailovich
Published: October 2022

The object of the study is the mechanism of interaction between the investigative units of the internal affairs bodies and the investigation units of the Ministry of Emergency Situations of Russia at the initial stage of conducting a procedural check on the fact of a fire, identifying shortcomings in the organization of this interaction and finding ways to solve the identified problems. Crimes related to fires are under the jurisdiction of both the investigative units of the internal affairs bodies and the bodies of inquiry of the Ministry of Emergency Situations of Russia. However, in the vast majority of cases, when a fire is reported, it is not known whether a criminal act has taken place, and, if so, what is its qualification, based on which the body authorized to carry out a preliminary investigation. In practice, this leads to excessive bureaucratization of the process of procedural verification, unjustified repeated transfers of verification material from body to body, inconsistency of the initial verification measures and partial duplication of the work carried out. The scientific novelty of the study lies in the fact that the attention of the authors is not focused on the issues of the methodology of fire investigation, but on the organizational aspects of this process that affect the efficiency of solving crimes of this category and preventing the occurrence of such a problem as the loss of criminally significant information, the result of which is extremely low efficiency of the process of disclosure and investigation of crimes with increased labor costs. Based on the results of the work carried out, significant problematic issues related to the conduct of initial investigative actions on the fact of a fire have been identified, and solutions have been proposed to improve the effectiveness of solving crimes related to fires
Submarine forces of the Red Banner Baltic Fleet on the eve of the Great Patriotic War
Authors: Osipov Yurii Anatol'evich
Published: October 2022

The subject of the study is the state of the submarine forces of the Red Banner Baltic Fleet on the eve of the Great Patriotic War, in particular, the issues of the operational and tactical situation in the theater, combat and political training of personnel, the level of organization of supplies and medical and sanitary support, as well as military discipline of the Red Navy and commanders. The purpose of the work is to determine the level of combat readiness of the submarine forces of the fleet at the time of the outbreak of the Great Patriotic War. On the basis of archival documents, sources of personal origin, as well as specialized literature, the author analyzes the peculiarities of the activities of Baltic submariners in 1940 – the first half of 1941. For the first time within the framework of this topic, along with the analysis of the capabilities of warships, the most important criteria for the combat readiness of large naval formations are considered the issues of moral and psychological state, as well as its factors formations. This approach determines the scientific novelty of the research. When developing the question, the author resorted to the use of a set of methods of historical research. The historical and systematic method allowed us to present the structure of the submarine forces of the Red Banner Baltic Fleet, its organizational and combat capabilities. The historical-comparative method made it possible to identify the features of general processes and their impact on the combat training of brigades and a division of submarines of the fleet. The quantitative method also played an important role in the study of the issue, which made it possible to generate statistics on a number of important issues: disciplinary practice, medical and sanitary provision, numerical characteristics of personnel. In conclusion, a conclusion was made about maintaining a high level of combat readiness of submarine brigades, however, a number of negative phenomena were identified, such as a low level of military discipline, significant difficulties in organizing supplies, the need to develop new operational areas, which somewhat reduced the combat readiness of the submarine forces of the Red Banner Baltic Fleet in the conditions of a possible confrontation between Germany and the USSR.