bluuebunny/crossref_metadata_2025 huggingface dataset:
DEYING OF ELASTIC TISSUES WITHOUT DIFFERENTIATION: NEW, QUICKLY METHOD
Authors: Abramović M. , Pavlović R.
Published: November 2024

Our methodological procedure established successful technique of the direct dyeing of elastic fibers and lamellas in elastic tissues. Experiments were carried out on a human autopsy material. Blocks rich in elastic fibers were fixed by 10% buffered neutral formaline and cut in the thickness of 5m. Deparafining of slides is done by xylol treatment (2x15min). Additional denaturation is achieved by combined solution, which contains 1.2g of picric acid in 30% solution of glacial acetic acid. By chloramine B application as blocking agent in form of 1% DMSO solution the dyes affinity for eviromental tissue is decreased. Tissues prepared in this way are treated with 0.5% solution of acidic sulfonic color Evans Blue (C.I.23860) in ratio 2:1. Lamellas are dark violet with light violet periphery. Obtained results speak in favor of high applicability of this method in light microscopy. In our opinion, this method can be recommended as one of methods for identification of elastic tissues.
POSTMENOPAUSAL WOMEN SEXUALITY
Authors: Bjelica A. , Kapamaðija A , Mladenović-Segedi Lj. , Trninić-Pjević A. , Džordžević R.
Published: November 2024

Women sexuality is a complex phenomenon encompassing biological, psychological, emotional and social aspects. The menopausal changes have undoubtedly a significant influence on sexuality. There is a widespread opinion that older women show a fading interest and desire for sexual relations. However, despite of all unavoidable changes brought about by menopause and elder age, the sphere of sexuality remains still very important. The paper reviews the changes occurring in the sphere of sexuality in the older age, influence of menopausal hormaonal changes, psycho-social factors and general health state in these changes, as well as of the possibilities of treating sexual dysfunctions in the menopausal period.
COMPLICATIONS OF BRONCHIECTASIS
Authors: Dolićanin Z.
Published: November 2024

On autopsy material of fifty corpses, age 0-75 (Institute for Pathology of Medicine Faculty in Belgrade and KBC
Dragiša Mišović - Dedinje, Beograd) we have met with all kind of comlications of bronchyectazia and bronchyloectazia
which were mentioned in literature. All statement complications, which caused death, we classified into lung and out lung
ones. Among lung complications, we stated that pneumonia among children in a big number of cases of congenital
bronchyectazia and cystic fibrosis of lungs. The apses of lungs were represented in four cases of secular and spindle shaped bronchyectazia and in one case of distal secular bronchyectazia it was represented in empiem pleure. In two cases lung gangrene was noted. Among out lung complications we can emphasize two cases of sepses of brain Apses. Leptomeningitis was present at one case. Among long-term spread bronchyectazia and bronhyloectasis with chronically manure inflammation and lung abscesses (bronchiectasiae abscendons), we stated the deposit of amiloids in glomerulus's and blood vessel of kidney intersticium as well as in liver and spleen. Chronical lung heart (cor pulmonale chronicum) was the most often complication of bronchyectazia and bronchyloectasia in the middle and older age period of our cases and it had represented the major cause of death.
PRINCIPLES OF NUCLEAR MAGNETIC RESONANCE
Authors: Vuković B.
Published: November 2024

Nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) today is the most powerful review method of a human body. Method is based on effect strong magnetic field and on demonstration of natural physical characteristics of nucleus. Hydrogen atom is a part of almost every compound in our body (water, lipids, proteins and nucleid acids).
When we exposed body to strong magnetic field hydrogen nucleus orients in direction of field, which cause resonance and
6 8 emission of radio signals. Resonance frequency for MRI is in range from 10 Hz to 5x10 Hz, which is equal to energies from -28 -25 6x10 J to 3x10 J.
TREATMENT CONDYLOMATA GIGANTEA
Authors: Perišić Ž. , Vukićević D. , Džinić M. , Dimitrijević Lj. , Perišić S.
Published: November 2024

Condylomata gigantea is an expansive, destructive lesion that affects most frequently anal and perianal region, and
rarely vulvar and vaginal region. We will describe a clinical case of a 28 years old female patient with a diagnosis of Condylomata gigantea in anal and perianal region with propagation on vulva, vagina and clitoris. After we detected a wide base of condylomas in anal and perianal region, we performed a deep, multiple biopsy for discover of eventual malignancy.
Histologically, malignancy was not confirmed, but it was discovered a presence of HPV types 6 and 11. The patient was initially treated with a wide surgical excision, and then the rest of condylomas were removed using CO laser which had an 2
haemostatic function in the same time. Three months later, there was no recurrence.
NEW PHARMACOLOGYCAL APPROACH IN GLAUCOMA TREATMENT USING SOL. XALATAN WHICH IS REGISTERED AS A FIRST CHOICE REMEDY IN EU. Case repport of the high iris insertion.
Authors: Elek-Vlajić S.
Published: November 2024

Trabeculodisgenesis of the primary congenital glaucoma because of the iris affiliate in front of the scleral ridge in
angulus iridocornealis. It is treated both surgically and with medication. We have showed you a patient which has, by the
time of illness diagnosing, developed morphological and functional optic papilla damages. We have applied both
comparative examinations and x-rays before and after sol. Xalatan therapy. With the research which is stillin progress, it is
estabilished that the values of intraocular pressure are brought to statistically normal frame (1,3 kPa-2,9kPa) and the
progression of both eyes´ optic nerves ganglion cells decadance is reduced, too
THE ROLE OF ANTROPOLOGISTS IN FORENSIC INVESTIGATIONS EXHUMED DEAD BODIES IN KOSOVO AND METOHIA FROM 2001. to 2004.
Authors: Matejić S. , Dobričanin S. , Milošević M. , Jakšiċ V.
Published: November 2024

Very important role in the forensic investigation of mass graves takes forensic anthropology. Anthropologists take
part during the exhumation and later through the investigation and identification procedures. Forensic investigations of
mass graves in Kosovo and Metohija are going on. In this paper we observe all cases that were exhumed and identified during 2001., 2002., 2003. till the 1. 05 2004. In this time 280 dead bodies were exhumed and forensic team did autopsies, but
111 dead bodies were identified. Our aim was to analyze anthropological measurments (gender, age and stature) and compare them with the real state on identified dead bodies. Scientifics all over the world made the record of the very good results
of anthropology work. After our investigation we can say that anthropology is very valuable during the exhumation of mass
graves.
CENTRAL VENOUS CATHETER FOR HEMODIALYSIS - CURRENT PROBLEMS
Authors: Stolić R. , Jovanović A. , Perić V. , Sovtić S. , Novaković T. , Dejanović B. , Rašić D. , Stolić D.
Published: November 2024

The retrospective study included all patients treated at Clinical Centre in Kragujevac, who needed an acute HD treatment due to vital endangerment, during 2003. The objective of this study was to demonstrate our experiences in treating these patients using central venous catheter. The results of this study show that femoral catheters are dominant (over 95%), with slight using of jugular and subclavial catheters (5%), in spite of the recommendation of the American Association for Renal Diseases to use femoral catheters only for patients supposed to be in hospital during the interval of 5 days. The
frequency of infections in our study (16,6%), coincides with the data of the American Association for Nosocomial Infections (NNIS)[1] (17,8% catheter infections). Gram-positive bacterium from Staphylococci group are the most frequent cause of catheter infections also in our patients
QUANTIFIED APPROACH TO FYBROMYALGIA
Authors: Mekić M. , Ristić M. , Ristić M. , Nestorović V.
Published: November 2024

Fibromyalgia presents a great clinical problem. Existence of no objective criteria for diagnosis is the key problem of this disease in the clinical rheumatology. The task of this work was to present the most practical quantification of fibromyalgia in every-day practice. Out of 37 patients there were 29 (78,3%) women, and 8 (21,6%) men. Out of this number there were 3 (8,1%) with primary fibromyalgia, 8 (21,6%) with secondary fibromyalgia, 25 (67,5%) were concomitant, whereas there was only one atypical case, i.e. (2,7%).
PSEUDOACANTHOSIS NIGRICANS, KERATOSIS PILARIS, STROFULUS INFANTUS, OBESITAS
Authors: Relić M. , Živanović J.
Published: November 2024

We want to present a boy with a several different, but benign disorders. Keratosis pilaris and strophulus infantum are very frequent, esspeciallv in children. Its association is not important. Pseudoacanthosis nigricans is especially associated with obesitas, and then this disorders is benign
PENIS INJURY CAUSED BY A BITE
Authors: Stefanović G. , Ivanović D. , Petronić D.
Published: November 2024

Considering the fact that there are freer and more varying sex activities, we have today more varying genital organs injuries both at men and women. We present you a patient with two penis injuries caused by a bite. It must be done a complete wound treatment with ATprotection and maximum antibiotics appliance. It is necessary to perform an AIDS test.
DRUG TRANSITION THROUGH THE BLOOD-BRAIN BARRIER AFTER THE RETROGRADE INTRAARTERIAL APPLICATIO
Authors: Stević S. , Jakovljević V. , Mitić R. , Žorić L. , Stanojević Z. , Bukumirić Z. , Bulajić S. , Bursać M. , Vitković L.
Published: November 2024

Transition of xenobiotics from blood into brain tissue is limited by the blood-brain barrier (BBB), a very selective functional barrier that excludes penetration of various substances, while allowing essential nutrients to enter into CNS. Transport of drugs through the intact BBB depends of their physico-chemical characteristics, the way of drug application and of anatomical and functional integrity of the barrier. The aim of this work was to examine penetration of quinine and lysinacetylsalicilate in vivo through the rat BBB, after the intraarterial injection via the a. axillaris in the course to CNS. The
experiment was done on anaesthetized Wistar rats, body weight 200-300 g. Test animals received injection of quinine (25 mg/kg) or LAS (90 mg/kg). Blood from the left jugular vein and brain samples (brain stem, cerebellum, right and left cerebral hemispheres) were taken in four minutes period. Quinine concentrations in rat brain were higher than in blood (ratio between blood/brain concentration was <1) while LAS concentrations in blood were permanently higher, according to their liposolubility. Maximal concentration in the brain tissue of both drugs are time dependent which indicated the useness of an active transport
SYMPTOMS, SIGNS AND ABNORMAL CLINICALAND LABORATORY FINDINGS IN WORKERS IN THE CHLORINE-ALKALI ELECTROLYZE
Authors: Ćorac A. , Trajković G. , Mirković M. , Kuzmanović P. , Vukotić M. , Samardžić S. , Mišolić V.
Published: November 2024

Elementary mercury using as cathode in process chlorine-alkali electrolyze. Mercury vapor makes in process going in work setting atmosphere. Aim of the work is to examine whether symptoms, signs and abnormal clinical and laboratory findings are in the correlation with work in the chlorine-alkali electrolyze. Examination of air pollution work setting discovers that the major factor of air pollution is mercury vapor. On periodical view at 2000, 2002 and 2004 year was examine 571 respondent, and their diagnosis was entered in report, from which was separated symptoms, signs and abnormal clinical and laboratory findings. Workers on different workplaces are exposes in different degrees. Examinees were divided in a four group according to the grade of exposure: I group day by day exposed; II group sporadically exposed; III group earlier exposed; IV group not exposed. I, II and III group are workers which work in the process chlorine-alkali electrolyze. IV group was control group and her compose administration personal. The statistical testing differences of frequency between groups according to the grade of exposure is showed there is statistical significantly difference between I and III, and II and IV groups. We are concludes that symptoms, signs and abnormal clinical and laboratory findings, statistically significantly, there is in persons which are permanently and long term worked in the chlorine-alkali electrolyze setting, from persons which are not permanently expose or nonexpose
THE NATALITY OF SERBS IN KOSOV SERBS IN KOSOVO AND MET AND METOHIJA
Authors: Perenić R. , Stolić R. , Kapetanović S. , Stolić D.
Published: November 2024

The birthrate in Serbia has been falling and we are the last country in Europe according the number of newborn children. The aim of this study was to establish the birthrate trend during the period of five years on the territory of Central Kosovo and Metohija, according the data of Gynecology- Obstetrics Clinic/Gracanica, to indicate the importance of an improvement of women's health care, increase the birthrate and population growth rate. There was used a retrospective method of examination of the data from the maternity hospital register in Gracanica. There were also used the data from the death registry in the local community of Donja Gusterica and the records of students enrolled into the first grade of Primary School in Donja Gusterica. During the period from March 2002 to August 2005 there were born 1718 children (912 boys and 806 girls). There is almost no family on this territory with less than three children and there is a significant number of families with four or five children. The number of women who bore six times was 24, seven times was 13 and eight times was 11 while there were two women who born the ninth child and one woman who bore the eleventh child. During the five-year period, on the territory of local community of Donja Gusterica, there died 169 people while, at the same time, the number of students enrolled into the first grade of primary School was 293. An important contribution to growth of natality is an improvement of the women's health care. There was noticed a constant increase in number of newborn children for the mentioned period as well as a significant increase in population growth rate in Central Kosmet
REACTIVE OXYGEN SPECIES
Authors: Kisić Božović B. , Mirić D. , Dragojević M. , Dragojević I.
Published: November 2024

Reactive products of oxygen are among the most potent and omnipresent threats faced by the living organism. Intracellular accumulation of reactive oxygen species such as superoxide anion, hydrogen peroxide, hydroxyl radical, and peroxy radical, can arise from toxic insults or normal metabolic processes. These species may perturb the cell's natural antioxidant defence systems, resulting in damage to all of the major classes of biological macromolecules, including nuclear acids, proteins, carbohydrates and lipids. Oxidative stress has been defined as a disturbance in the prooxidant-antioxidant balance, resulting in potential cell damage. It has been implicated in several biological and pathological processes like ageing, inflammation, carcinogenesis, ischemia-reperfusion and in diseases including diabetes mellitus, atherosclerosis, and/or neurodegenerative diseases
DIFFERENTIAL DIAGNOSIS OF PUSTULA MALIGNA
Authors: Relić M. , Vujičić C. , Dejanović L. , Krstić N. , Ivanović J.
Published: November 2024

The pustula maligna is most often clinical form of antrax. Disease is today a relative Rarity, but its appearance (sporadic or in epidemia) always to be surprised, especially in the biology war. Antrax have a big significant and today, we analyzed clinical findings of pustula maligna and its differential diagnosis. 
PLACE OF ZINK PREPARATION AS DIETETIC SUPPLEMENT IN NON-INSULIN-DEPENDENT DIABETES MELLITUS
Authors: Stanojević Z. , Mitić R. , Stević S. , Bukumirić Z. , Biševac B. , Miletić M. , Bulajić S.
Published: November 2024

Considering its importance in cell replication and differentiation, programmed cell death, DNA transcription, function of hormones, biological membranes and immunological system, zinc probably has a major role in enabling a proper
function of different tissues, organs and organic system in general. As an essential micronutrient wich is directly involved in metabolizm of insulin, zinc play important role in pathogenesis of diabetes mellitus and its complications. On the other hand, low zinc absorption and hyperzincuria in diabetic animals and humans have indicated that diabetics are more susceptibile to zinc deficiency compared to healthy persons. Inasmuch as zinc plays an important role in syntesis, storage and secretion of insulin as well as conformational integrity of insulin in the hexameric form, zinc deficiency may adversely affect the ability of the islet Numerous studies suggested that urinary zinc excretion was higher in diabetes mellitus, probably as result of hyperglycemia. In contribution, there are findings about correlation between urinary zinc excretion and blood glycosylated hemoglobin (HbA1c) levels in non-insulin dependent diabetic patients. Recent experimental investigations showed that zinc supplementation inhibited NF-kB activation in the pancreas and decreased the expression of inducibile nitric oxide synthase, a downstream target gene of NF-kB. The ability of zinc to modulate NF-kB activation in the diabetogenic pathway may be the key mechanism for zinc's protective effect and important criterion for choosing nutritional strategies for diabetes mellitus prevention.
EHOCARDIOGRAPHIC CHARACTERISTICS OF LEFT VENTRICLE IN NON-Q ACUTE MYOCARDIAL INFARCTION
Authors: Sovtić S. , Tomić S. , Trajković V. , Jovanović A. , Marčetić Z. , Perić V. , Stolić R. , Novaković T. , Lazić S. , Pajović S.
Published: November 2024

In this work we have examined echocardiographic characteristics of left ventricle in patients with acute myocardial infarction (AMI). We used prospective study, during 12 months, and we followed 55 patients with diagnosed non Q AMI. All patients were hospitalized in the Coronary unit. Results: 55 consecutive (40 males middle age 55,4±8,7 and 15 females middle age 57,4±10,3) had non Q AMI. Value of ejection fraction: after 4.day - 50,4±6,2% ,2.weeks - 54,6±5,8%, 4. weeks - 59,3±5,4%. Value of ejection fraction in patients with thrombolytic therapy: 61,6±6,8% vs. 57,3±6,6% p> 0,05;Value of left ventricle fractional shortening: 28,8±2,5% (in patients with thrombolytic therapy 30,3±4,8% vs.27,2±5,9%) Value of end2 2 2 - diastolic volume: after 4.day- 62,5±5,3 ml/m , 2.weeks - 63,1±5,4 ml/m , 4. weeks - 64,4±5,8 ml/m (in patients with throm 2 2 2 bolytic therapy 60,5±9,2 ml/m vs. 67,4±8,4 ml/m ) Value of endsistolic volume: after 4. day - 26,2±2,1 ml/m , 2.weeks2 2 26,8±2,3 ml/m , 4. weeks - 27,6±2,2 ml/m (in patients with thrombolytic therapy 25,6±2,8 ml/m2 vs. 31,7±3,1 ml/m2 p> 0,05). During the in-hospital follow up period, 2(3,6%) patients and during the post-hospital follow up period, 1 (1,9%) patients with non Q AMI had lethal outcome.
VITAMIN C CONCENTRATIONS IN SERUM BEETWEN PATIENTS SUFFERING FROM DIFFERENT FORMS OF NON-SPECIFIC OSTEOMYELITIS
Authors: Mirić D. , Grbić R. , Vasić A. , Božović B. , Dragojević I. , Marković M. , Nestorović V.
Published: November 2024

Bone tissue infections caused by non-specific agents (non-specific osteomyelitis) occur most frequently among children and young individuals demanding surgical and antibiotic therapy, although with unpredictable clinical outcome. While mobilization of cellular response to infectious agents takes place, a bulk of oxygen-derived free radicals emerge with concomitant participation of various elements of endogenous antioxidative defense. Vitamin C is an endogenous antioxidant active in the aqueous phase. It is very likely that ostoemyelitic patients already have some kind of disorder in specific antioxidant system due to hematogenic origin of non-specific osteomyelitis. Our results show that serum total vitamin C concentrations among patients with non specific osteomyelitis are not significantly different from those obtained among control subjects. However, we found significantly different concentrations of ascorbate, dehyroascorbate and their concentration ratio in serum within osteomyelitic patients that points to enlarged consumption of ascorbate even before the bone localization of infection took place
FATS OF DIFFERENT ORIGIN IN NUTRITION AS A RISK FACTOR IN THE DEVELOPMENT OF CEREBRO-VASCULAR INSULT (STROKE)
Authors: Petrović-Oggiano G. , Damjanović V. , Pavlović M. , Ristić G. , Glibetić M. , Mitić R.
Published: November 2024

The aim of the paper was to investigate whether nutrition based on animal fats in the group of patients who used them as dominant-group S ( the patients of Greek Orthodox creed), is a more signifikant risk factor in the development of stroke than nutrition based on vegetable fats-group A( the patients of Muslim creed). At the same time, the aim of the article was to find the parameters of lipid status which would define in a better way the connection between hypercholesterolemia and apoplexy. The research was done on 230 patients with ischemic CVI who underwent hospital treatment at the Neurological Clinic of the Clinical-Hospital Centre in Pristine. The patients at the Neurological Clinic of the Clinical-Hospital Centre in Pristine were divided into two groups: Group A (n=130)- the patients who based their nutrition mailnly on vegetable fats (the patients of Muslim creed) and Group S (n=100)- the patients who based their nutrition mainly on saturated fats ( the patients of Geek Orthodoc creed). It was stated that the intake of both vegetable and animal fats in larger quantities bears a risk of the development of the cerebra-vascular insult. The intake of saturated fats is a higher risk factor leading to the increased values of cholesterol, triglycerides and LDL-cholesterol in the group of patiebts of Greek Orthodox creed (group S) in comparison to the group of patients of Muslim creed (groupA).
THE USE OF THE USE OF ANTITUBERCULOSIS DRUGS (A ANTITUBERCULOSIS DRUGS (ATD) TODAY
Authors: Rašić J. , Janićijević-Hudomal S. , Radišić D. , Bukumirić Z. , Stanojević Z.
Published: November 2024

The World Health Organization (WHO) declared tuberculosis (TB) a global emergensy in recognition of its growing importance as public health problem. In response to this situation WHO in 1990 was developed new strategy and framework for effective TB control, wich was called „DOTS“. The aims of treatment of TB are: to cure the pation of TB, to prevent death from active TB or its late effects, to prevent relapse of TB, to decrease transmission of TB to others, and to prevent
the development of acqured drug resistance. Antituberculosis drugs (ATD) are antibiotics and synthetic drugs used in the
treatment of tuberculosis and other deases caused by microorganisms of the genus Mycobacterium. The essential ATD are:
isoniazid (H), rifampicin (R), pyrazinamid (Z), streptomycin (S), ethambutol (E), and thioacetazone (T). The reserve ATD
are: amikacin (Am), kanamycin (Km), capreomycin (Cm), ciprofloxacin (Cx), ofloksacin (O), cycloserine (Cs), ethionamide (Et), protionamide (Pt), and p-aminosalycilic acid (PAS). The regimen recommended for each patient depends on the
diagnostic category for each patient. There are several possible regimens. ATB treatment regimens consists of two phases:
an initial phase and a continuation phase
PSYCHOLOGICALASSESSMENT IN SURGICALLY TREATED PATIENTS WITH LUMBAR RADICULOPATHY
Authors: Tomašević-Todorović S. , Mišolić-Dejanović M.
Published: November 2024

High frequency of appearance and use of expensive diagnostic and therapeutic methods makes lumbar radiculopathy the most expensive benign disease. The aim of the study was evaluation of types psychological reactions in surgically treated patients with chronic lumbar radiculopathy. Matherial and methods: We examined 50 surgically treated patients who had low back pain. The patients were multidisciplinary examined and treated on Medical Rehabilitation Clinic in Novi Sad. The Minnesota Multiphasic Personal Inventory (MMPI) was used to determine the personality profiles. Patients were tested after rehabilitation treatment. Results of the exploring showed the normal profile of personality in 70 % of patients and pathological profile in 30 % ( hypochondria in 8, hysteria in 5 patients and depression in 2 patients). All groups showed improvement in functional limitation during the rehabilitation treatment. Severity and length of pain after rehabilitation treatment is bigger in the group of patients with pathological profile of personality (p<0,005). Psychological factors may play an important role in the onset, severity, exacerbation, or maintenance of this type of chronic pain. Screening surgically treated patients with chronic lumbar radiculopathy with MMPI may be effective in identifying psychopathology
VARIATIONS OF THE RELATIONSHIP BETWEEN MAXILLAAND MANDIBLE st nd rd TO CRANIAL BASE IN PERSON WITH 1 , 2 AND 3 CLASS BY ANGLE
Authors: Vukićević V. , Pavlović J. , Vujačić A. , Simić S.
Published: November 2024

Introduction: In 1899. Angle introduced his own classification of malocclusions which was established anteroposterior relationship between maxilla and mandible.Later cephalometric examinations showed possible variations of the relationship between maxilla and mandible to cranial base, in all three classes. The aim work: The aim of this work was to ascertain types of the relationship between maxilla and mandible to cranial base in persons with I,II and III class by Angle. Material and method:The profile telerendgenograms were used in male and female aged aprroximately 14,5 years. On the bases of clinical examination and analysis of models,the patients were previously distributed into three groups with 50 examinees in each,according to Angle classification of malocclusions in saggital plain.SNAand SNB angle were analysed, and on the bases were individual values, the type of the relation between maxilla and mandible to cranial base was determined for every examinee. Results: In persons with Angle I class, eight types of the relationship were determined,while five types in persons with Angle II and III class of the relationship of jaw to cranial base. Conclusion: Because of large number of variationsof the relationship of jaw to cranial base diagnostic procedure should evolve, and treatment of the very similar cases should be different
PATHOLOGICAL CHANGES OF VAGINAACCOMPAINED WITH HUMAN PAPILLOMA VIRUS INFECTION (HPV)
Authors: Vukićević D. , Perišić Ž. , Plešinac-Karapandžić V. , Vančentović-Mijović M. , Đerković B. , Vitković L. , Mitić N.
Published: November 2024

Apart from great frequency of epithelian, especially preinvasive changes, some very rear diseases common for other lower parts of genital tract (cervix and vulva), are vaginal epithelian changes and especially vaginal intraepithelial neoplasia (VAIN). That's the reason why we don't usually think about this disease, which can have very serious consequences, especially in late discovering of changes in the stadium of invasive malign disease.The aim of this work was to diagnose all pathological changes on vagina: benign, premalign and malign, according to the age of female patients. Biopsy and operative material taken from 1331 female patients treated in Ginecology and Obstetrics Clinic “Narodni front” in Belgrade, were used in this study. The most diagnosed benign changes was condylomata acuminate (42%). Out of 20 cases of premalign changes, VAIN I was diagnosed in 5 cases (25%) as a slight degree of premalign changes, while VAIN II and VAIN III were diagnosed in 5 cases as a severe degree of premalign lesions. Out of 11 cases, there were 3 cases (27.27%) of invasive planocellar vagina carcinoma with histological degree G1N1. 8 cases (72.72%) were with histological degree G2N2, while there were not a single case with histological degree G3N3. Planocellar vagina carcinoma is the most common in the age of 41-50.
THE APPROACH TO THE PATIENT WITH CEREBRAL-VASCULAR INSULT (STROKE) IMMEDIATE BEFORE AND AFTER NATO BOMBING
Authors: Radomirović M.
Published: November 2024

We have been analyzing a number of patients with cerebral-vascular insult in a period of 1998-2003 year, clinical picture in the time of the reception, the development of the illness, the result and the therapy access in the Neuropsychiatric Department of Health Center in Kosovska Mitrovica. It is concluded that the number of CVI is significantly higher after the NATO bombing, the development of the illness more difficult and a detailed analyses of the causes is in progress. In a period of 01. 01. 1998 until 31. 12. 2003. year, 1829 of patients have been on hospital treatment and 252 of them have been treated from CVI, in the Neuropsychiatric Department of Health in Kosovska Mitrovica. During clinical prospective, retrospective and static research in has been concluded that:in the above mentioned period the number of CVI patients have been increasing in regard to the total number of treated patients in Neuropsychiatric Department of Health Center in Kosovska Mitrovica. The percentage of CVI relapse is increasing(the highest percentage is in 1999). It has been established that besides the well known causes for the occurrence of CVI such as:hypertension, the heart disease, disorders of heart rhythm, endocrine disease(Diabetes mellitus) end also the well known factors of risk for causing of mentioned diseases(corpulence, raised value oh cholesterol in blood, smoking, insufficient physical activity, excessive consuming of alcohol etc). Relevant factor for the occurrence of CVI is the factor of stress, social and territorial isolation of the Serbian population immediate after NATO bombing on the territory of Kosovo and Metohija.
"C E A P" CLASSIFICA CLASSIFICATION CHRONIC TION CHRONIC VENOUS DISEASE VENOUS DISEASE
Authors: Dimić S. , Petrović D. , Dimić I. , Vučinić B. , Janković R.
Published: November 2024

Chronic vein insufficiency (CVI) is abnormal functioning of a system of veins resulted from incompetence of vein valves, with or without vein obstruction covering both surface and deep veins. Nowadays there are various standars in the diagnosis of CVI and variations of treatment modalities, which increases the importance of occuracy and foundations of the diagnosis. In the consideration of diagnostic needs of patients with CVI, CEAP classification is suggested. This classification defines clinic categories, etiology of problem, covered anatomical segments and pathological mechanisms of CVI.
DEPRESSION AND SUICIDALATTEMPTS AT TREATMENT ACNE VULGARIS WITH ISOTRETINOIN
Authors: Dejanović L. , Relić M. , Radević T. , Nenadović M.
Published: November 2024

Oral isotretinoin is highly effective in treatment of patients with severe acne, but has been concerned with causing occasional depression. Clinicians should be alert to the high prevalence of depression among people with acne. Isotretinoin has many unwanted effects, among which possible unproven effects on mood have to be included. If depression or other mood change occurs, then isotretinoin treatment should be discontinued. If treatment is continued, psychiatric support should be obtained.
LIVER RESECTION AT ECHINOCOCCUS CYST
Authors: Mladenović J. , Videnović N. , Sekulić S. , Mladenović S. , Mladenović R. , Lukić P. , Aranđelović S.
Published: November 2024

Echinococcus is a zoonosis, parasitic disease, caused by echinococcus granulosus, E. multilocolaris, E. Vogeli and E. oligarthus. The most frequent at humans is a cystic form of the disease caused by E. granulosus, and rarely the alveolar one caused by E. multilocolaris seu alveolaris. It can affect all the organs and tissues. The most affected ones are: liver (70- 80%) and lungs (10-25%), while rarely, at 5% it can be found in spleen, kidneys, brain, heart, pancreas, mussels and skeleton. The only secure treatment of the primary echinococcosis is the surgical one. It should start immediately after the diagnosis is set in order to avoid complications which follow echinococcosis. Several surgical methods are used in practice for live echinococcus treatment: partial pericystectomia, total cystopericystectomia and liver resection. Aim of the work is to show the importance of the echinococcus cyst of liver and treatment methods. The patient presented in the work is Dj.G., female, register number of the disease history 355/14.05.2007., 61 years old, hospitalized at Surgical Clinic because of the surgery of echinococcus cyst on the left liver lobe. Diagnosis was set by abdomen USG, CT of the abdomen, and laboratory analyses. During the surgery, we found a big echinococcus cyst localized in the second and third segment of liver, so we did a liver resection as a bisegmetectomia with total ekstirpacija of the cyst. Postoperative flow passed normally and the patient
was on the eight postoperative day sent to further home care in a generally and locally good state.
RECONSTRUCTION DEFECT RECONSTRUCTION DEFECT ORBITAL FLOOR WITH SYMPHYSEAL WITH SYMPHYSEAL GRAFT
Authors: Tabaković S. , Videnović G. , Mirković M. , Krasić D.
Published: November 2024

Fracture of orbital floor is relatively frequenthly injuries. Fractures can appear same in war or peacefull conditions. War injuries can be bursting, and in many cases is very hard, with fracture, dislocation and defect more of orbit walls. Peacefulls injuries orbital floor appear mostly in car exident, fight, fall on face, and also in sports activity. Regarding specific anatomic structure, sensitive position and content of orbital cavity, even today exists different opinion especially by question of mechanism of originate, same as question of injury treatment.
ELECTROCARDIOGRAPHIC AND HEMODYNAMIC CHANGES IN ANESTHETIZED DOGS UNDER THE INFLUENCE OF VERAPAMIL
Authors: Milanović Z. , Pavlović A. , Jovanović P. , Biševac B. , Miletić M.
Published: November 2024

The most important characteristic of calcium channels is a selective regulation of a slow incoming current of calcium into the tissue cells with tendency of a slow growth of the action potential. Such tissues include smooth muscles of the blood vessels, cardiocities and hearth noduses (AVand SAnode). Different calcium antagonists have different influences on the mentioned tissues, because they also have different chemical components. Verapamil, Nifedipin and Diltiazem have the most common usage. Verapamil is a product of papaverine, nifedipin is a product of dehydroperidine while diltiazem is a product of benzodiazepine. Their common characteristic is blocking the calcium channels which cause blood vessels vasodilatation, negative inotropic and negative chronotropic influence. By blocking calcium to enter through channels spores of miofibrile smooth muscles, calcium antagonists are reducing the amount of available calcium for contraction, which causes vasodilatation. One of the best-known and the commonest calcium antagonist is verapamil. In electrophysiological terms, it inhibits action potential of the heart noduses (especially AV node), where the most important thing for depolarisation, is a slow entrance of calcium. By extending the refractory period of SA node, it reduces the frequency of impulse generation (heart frequency), while by extending the refractory period of AVnode, it slows down the work of chambers in cases of flater and atrium fibrillation. Taking into consideration the fact that verapamil shows cardiodepresive effects, the aim of our work is to study closely its effects on electrocardiogram and hemodynamic parameters. The experiment was conducted on six adult, healthy dogs which were, after 10 minutes 0,9% NaCl infusion, treated with i.v. bolus verapamil injections on every 5 minutes until the appearance of intoxication signs, which causes bradycardia, heart rhythm disorder and the fall of arterial blood pressure. The average verapamil dose was 4 mg per kilogram. After i.v. verapamil administration, heart frequency and middle arterial pressure have a significant fall, while central venous pressure has a significant rise. Larger verapamil doses nd rd can significantly extend T-P and P-R interval with the appearance of AV-block (2 and 3 grade), while the Q-T interval doesn't show any significant change.
THE IMPORTANCE OF EARLY WARNING SCORE IN PREDICTING IN-HOSPITAL CARDIAC ARREST
Authors: Trpković S. , Pavlović A. , Jovanović A. , Videnović N. , Jovanović P. , Bojanović P.
Published: November 2024

The Early Warning Score is a simple physiological scoring system that can be calculated at the patient's bedside, using parameters which are mesured in the majority of unwell patients. Patients suffering in-hospital cardiac arrest often have abnormal clinical observations documented prior to the arrest. Study objestives:This study assesses wheather these patients have less favourable outcome following in-hospital cardiac arrest. Matherials and the methods:For the present study, the patients' hospital charts were reviewed to identify possible abnormal observations within 8 h prior to the arrest. Results: From the total of 100 patients who sufferd in-hospital cardiac arrest, 64 patients had documentation of vital signs and 9 patients had no documentation of vital signs. Of the patients with documented vital signs 27 (29,7%) had normal vital signs and 64 (70,3%) had abnormal observations. Among these 64 patients the distribution was as follows: 17 patients (13,1%) had respiatory rate below 8 or over 20 per min, 40 (30,8%) had puls rate below 40 or over 140 beats per min, 20 patients (15,4%) had systolic arterial blood pressure below 90 or over 200 mmHg, 5 (3,7%) had temperature (˚C) below 36,1 or over 37,9 ˚C, 20 (15,4%) had oxygen saturation below 90%, 14 (10,8%) had decrease in consciousness and 14 (10,8%) had urine output below 50 ml/2hours). Compared with patients whose EWS were 0-2 (ОR 1,2; 95% CI: 0,935-1,507) patients with EWS 3 or more were 6,5 times more likely to die in first 24 hours (OR: 7,8; 95% CI: 1,205-50,205). Conclusions:Patients with documented clinically abnormal observations prior to in-hospital cardiac arrest have a worse outcome than those without. The main implication of these is that these patients need to be identified in time thereby possibly avoiding arrest. This can also be used when assessing the prognosis of in-hospital patients after achieved ROSC.
POSSIBLE COMPLICATIONS OF TOTALANESTHESIAE DURING CAESAREAN SECTION
Authors: Relić G. , Grujić K. , Cvetnić D. , Bogovac M. , Vlašković R.
Published: November 2024

The authors in this work presented the case of itterative Caesarean Section. In this intervention they had a complication of endotracheal anaesthetic. Although general anaesthetic, according report the most authors, generally appliance anaesthetic during Caesarean Section, this anaesthetic have a certain failure. This are: difficult intubation, intubation in oesophagus, insufficient relaxation on myometrium, risk of depression - foetal’s central nervous system, unadequate reaction on drugs etc. Some authors have a pioritydaju of regional method according safety. Because of that all we believe, that heed is necessary in work and everybody obstetrician must conscious of this risk, like as application generally anaesthetic such as and regional anaesthetic by woman who has just given birth. In this effect we suggest that knowledge and experience of anaesthesiologies are very important.
FLOW/ PRESSURE AND FLOW/ VOLUME CURVES IN DIFFERENTIATION OF THE OBSTRUCTIVE CHANGES IN TRACHEOBRONCHIAL TREE
Authors: Matinić N. , Popović Lj. , Mirić M. , Đokić T.
Published: November 2024

Conducting research in the field of respiratory function, by using measuring and testing, has many purposes. First of all, it could show us how lungs function as a whole, but also, it could lead us to the exact location of a disorder. The aim of this paper is to, by employing accurate correlation of the measured variables of the flow/volume and flow/pressure curves, determine the location of the obstruction process in the tracheobronchial tree, in central-upper airways, as well as in a segment of small airways, so called 'silent zones' of the lungs, smaller than 2 mm in internal diameter. This research included 115 healthy people and 106 patients with chronic obstructive lungs disease, of both genders. The following values of the measured lungs' function parameters were found among healthy people (% of predicted value): FVC- 93%; FEV - 91,1 %; 1 FEV x 100/ FVC- 98,7%; MEF - 107,9%; MEF - 87,5%; MEF-98,9%; Rt-147,1%; ITGV-103,3%; SRt- 130,7%. 1 25%FVC 50%FVC Among the patients with chronic obstructive bronchitis, the following results of the examined parameters were gained: FVC- 66,3%; FEV - 54,2%; FEV x 100/ FVC- 80,7%; MEF - 19,3%; MEF - 23,1%; MEF- 40,5%; Rt- 51,2%; 1 1 25%FVC 50%FVC ITGV- 162,1%; SRt- 36,2%. Finally, there was a certain number of the healthy examinees who showed that direct indicators of the air flow resistance (Rt, SRt) were not significantly changed, while indirect indicators of the respiratory tracts obstruction (MEF , MEF ) were reduced, comparing to the expected tabular results.
FREQUENCY OF CERVICAL PLANOCELLULAR CARCINOMA
Authors: Vukićević D. , Perišić Ž.
Published: November 2024

Today it is noticeable that the incidence and mortality from cervical carcionoma increases, especially the growth of
frequency of those changes at younger women. The total number of diagnosis of invasive carcinoma at the processed biopsy and operative matrials was 186. The majority of results were the histological grade G1 N1 54,83% in the group of 41-50 years old patients, and the less significant was number of histological grade G2 N2 at the age 51-60 and G3 N3 at patients over 60 years old. In 72 cases the radical surgical treatment was done after previously made HP diagnosis of planocellular carcinoma on the biopsy material, and it was done in the cases that were operable in stage Ib (FIGO). The most of operated women were with histological grade G1 N1, so we followed in what degree the size of tumor, beside the histological grade G1 N1, so we followed in what degree the size of tumor, beside the histological grade, have an effect on the possibility of presence of the metastasis in regional lymphatic nodes. We came to the conclusion that with the growth of macroscopically size of tumor, the frequency of appearance of lymphatic nodes increases. Those parameters could not the small number of operated cases. When the disease is discovered in these histological grades. It is not operable, and then we perform radiotherapy as a method of treatment.
ANTHROPOMETRIC PARAMETERS IN DETERMINING THE SIZE AND DISTRIBUTION OF FAT MASS IN SUBJECTS WITH METABOLIC SYNDROME
Authors: Inić Kostić B. , Novaković T. , Milinić S. , Trajković R. , Đokić N. , Nikolić S.
Published: November 2024

Metabolic syndrome is a common metabolic disorder whose primary feature is abdominal obesity, which is associated with a high prevalence of dyslipidemia, hypertension and glucose tolerance disorders. The goal was, determine BMI in subjects with metabolic syndrome and people with normal body weight, take anthropometric parameters (waist and hip circumference, and calculate WHR and WSR index) to assess the average degree of nourishment and body fat distribution. The research was conducted in Gracanica Health House. The study group consisted of 130 subjects that met the criteria for metabolic syndrome. The control group consisted of 40 randomly selected subjects during medical check-ups. The study group was dominated by female with 83. 08%, followed by 16. 92% of male subjects, with the average age of subjects being 56. 32 years. The average BMI index of the study group was 32. 22 kg/m², which indicates first-degree obesity, while the average BMI index of study group subjects was 24. 67 kg/m², which is within the normal nutrition range. By comparing the average values of anthropometric parameters, we established that the study group subjects had statistically significantly higher average body weight parameters (waist-to-hip ratio p<0,001), while the control group subjects had a higher average of body height (p<0,001). In both, study and control group, male subjects had a normal WHR, which is not the case with women. Therefore, there was a statistically significantly higher number of women with pathological WHR (p<0,001) than of men in both groups. The study group had a statistically significantly higher number of subjects with pathological WHR (p<0,001). The average WSR value (waist/BH) is statistically significantly higher in the control group (p<0,001). Obese individuals had significantly higher values of measured anthropometric intraabdominal fat indicators compared to normally nourished people. 
EPIDEMIOLOGICAL CHARACTERISTICS OF PATIENTS HOSPITALIZED BECAUSE OF CHEMICAL INJURY OF AN EYE
Authors: Stamenković D. , Vukša D. , Jakšiċ V. , Đokić O. , Mirković M.
Published: November 2024

Chemical injuries of the eye i.e. causoma means 4% up to 10% of all ocular trauma cases. Purpose: to determinate basic socio-epidemiologic characteristics of patients who has been hospitalized due to causoma. Method: prospective case control study carried on 54 patients who havå been treated at Department of Ophthalmology Health Center K.Mitrovica and Clinic of Eye Disease in Nis. Results: in total, 40 male and 14 women were injured (mean age 41.8 years). The bricklayers, painters and construction-workers are the most frequent injured. Injuries caused by alkalis were significant prevailing in relation to those caused by acids (64.8% vs. 35.2). Monocular causoma were almost twice more frequent. Accident as a manner of injury was in 96.3% of all cases. Men were injured by caustic lime and sulphuric acid while women were injured by sodium hydroxide, hydrochloric acid and acetate acid. More serious clinical appearance had a patients with injuries caused by explosion of accumulator because of associated mechanical injuries of the eye.
THE EFFECT AND INTERACTION ASPIRIN AND TICLOPIDINE ON HEMATOLOGICAL VARIABLES IN RATS
Authors: Stanojević Z. , Mitić R. , Nestorović V. , Valjarević D. , Hadžistević S.
Published: November 2024

The combination of aspirin and ticlopidine has been proven to reduce the frequency of haemorrhagic and vascular complications after coronary artery stenting, but also can cause serious hematological side effects. The purpose of this study was to evaluate the effect and interactions aspirin and ticlopidine on hematological variables. Thirty two Wistar rats were divided in four groups and they received intraperitoneal one of the following treatments for 4 days: group I - control, group II aspirin (50 mg/kg BM), group III - ticlopidine (125 mg/kg/day) and group IV - aspirin+ticlopidine combination (50 mg/kg/day+125 mg/kg/day). Hematological variables were determined at once after taking the sample of blood. Relationship between measured variables was determined by calculating linear correlation coefficient (r). The hematocrit, haemoglobin and red blood cell were significantly decreased in group treated with aspirin+ticlopidine combination compared to control (p< 0,05). Neutrophil and platelet count weren't significantly different in treated groups, but were slightly decreased in groups treated with ticlopidine and aspirin+ticlopidine combination. Between hematocrit and platelet count in control group of rats was noticed negative and medium correlation (r=-0,41), in groups treated with ticlopidine and aspirin+ticlopidine combination positive and medium correlation (r=0,52; r=0,69). Based on obtained results it can be observed significant decreased hematocrit, haemoglobin and red blood cell in group treated with aspirin+ticlopidine combination. The negative correlation between hematocrit and platelet count in control group becomes positive after the treatment with ticlopidine alone and aspirin+ticlopidine combination.