bluuebunny/crossref_metadata_2025 huggingface dataset:
The Interplay of Sensory Feedback, Arousal, and Action Tremor Amplitude in Essential Tremor
Authors: Welzel Julius , Güthe Miriam , Keil Julian , Hermann Gesine , Wolke Robin , Maetzler Walter , Becktepe Jos Steffen
Published: September 2023

Essential tremor (ET) amplitude is modulated by visual feedback during target driven movements. In a grip force task, tremor amplitude increased during large scale visual feedback compared to a condition with low scale visual feedback. It has not been examined whether visual feedback exclusively modulates target force tremor amplitude or if other afferent inputs like auditory sensation has a modulatory effect on tremor amplitude as well. Also, it is unknown whether the enhanced sensory feedback causes an increase of arousal in persons with ET (p-ET). We hypothesized that (1) amplitude of tremor is modulated by variation of auditory feedback in the absence of visual feedback in a force tremor paradigm; (2) increase of tremor amplitude coincides with pupillary size as a measure of arousal.
14 p-ET and 14 matched healthy controls (HC) conducted a computer-based experiment in which they were asked to match a target force on a force sensor using their thumb and index finger. The force-induced movement was fed back to the participant visually, auditory or by a combination of both.
Results showed a comparable deviation from the target force (RMSE) during the experiment during all three sensory feedback modalities. The ANOVA revealed an effect of the scaling factor on the tremor severity (Power 4-12Hz) for the visual- and also for the auditory feedback condition in p-ET. Pupillometry showed a significantly increased pupil diameter during the large scale auditory involved feedback conditions compared to the low scale feedback conditions in p-ET. Our findings suggest that action tremor in ET is firstly modulated not only by visual feedback but also by auditory feedback in a comparable manner. Therefore, tremor modulation seems to be modality independent. Secondly, enhanced feedback causes an increase of arousal as measured here by the pupil size. Further work including neurophysiological measures is required to better understand the interaction between arousal and target-related tremor.
Electromyographic Analysis of Elite Para Table Tennis Players with Complete and Incomplete Spinal Cord Injury during Forehand Loop and Backhand
Authors: Norouzi Mehdi , Ardakani Mohammad Karimizadeh , Mahmoudkhani Mohammadreza , Dibafar Majid
Published: September 2023

Background Para table tennis is a popular sport among individuals with disabilities, and each Paralympic sport has its own classification system. This classification aims to minimize the impact of impairments caused by disability on athletic performance. In the present study, the electromyographic variables of the muscles involved in performing the forehand loop and backhand techniques of elite para table tennis players with complete and incomplete spinal cord injuries in the class 5 category were compared. Methods In this study, there were 20 male participants at the national level. According to the ASIA scale, the participants were divided into two groups of 10 people. The first group had complete spinal cord injury, while the second group had incomplete spinal cord injury. After they entered the laboratory, the electrodes were connected to their deltoid, biceps, external oblique, and erector spinae muscles. After connecting the electrodes, the tasks were performed and muscles’ EMG activity, as well as their onset and offset contraction were monitored. Results The findings revealed that there are significant differences in the amount of EMG activity as well as the timing of the onset and offset of contraction of selected muscles in two groups of complete and incomplete spinal cord injuries. Conclusion The findings suggest that athletes with incomplete spinal cord injuries may perform better than those in the complete group. However, current para table tennis classification rules place both groups in the same class, which could impact the outcome of matches.
First Incidence of Parietal Lobe Metastasis in an Adult with Desmoplastic/Nodular Medulloblastoma: A Case Report and Review of the Literature
Authors: Zaresharifi Nooshin , Abbaspour Elahe , Yousefzade-Chabok Shahrokh , Reihanian Zoheir , Karimian Paridokht , Karimzadhagh Sahand
Published: September 2023

Background: Medulloblastoma in adults is a rare and highly aggressive central nervous system (CNS) tumor, representing less than 1% of all brain tumors. Supratentorial metastasis is uncommon, and extraneural metastasis occurs in approximately 5% of cases, primarily in frontal and temporal lobes. Here, we present a unique case of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma, adding a novel dimension to the existing knowledge base. We conducted a thorough search on the PubMed database to explore prior cases and establish the uniqueness of our case.
Case presentation: A 46-year-old male with a posterior fossa tumor and hydrocephalus was diagnosed with medulloblastoma seven years ago. Adjuvant concurrent chemoradiotherapy was administered after surgery. After five years, a surveillance brain MRI suggested possible tumor recurrence. A whole-body bone scan revealed widespread bone marrow metastases. Despite receiving adjuvant therapy in the past two years, the patient has experienced progressive right hemiparesis, ataxia, and gait disturbances. A brain MRI showed a distinct 6 x 4 x 2 cm in the left parietal lobe. The patient's tumor was entirely removed, initially suspected to be a parasagittal meningioma. However, it was identified as a supratentorial metastasis of desmoplastic/nodular medulloblastoma after a thorough histopathological examination.
Conclusion: Considering the possibility of tumor recurrence or intracranial metastasis in medulloblastoma patients is crucial. Regular treatments and follow-ups are strongly recommended to detect any signs of reoccurrence in these atypical presentations promptly.
The pathogenesis of Acute Exogenous Lipid Pneumonia based on proteomics
Authors: Weng Tingting , Wang Huamin , Xu Zijing , Liang Dongshi , Huang Airong , Ye Wanding , Hu Xiaoguang , Xu Zhiwei , Jin YiMei
Published: September 2023

Introduction
Acute exogenous lipoid pneumonia (AELP) is a rare disease. At present, the specific pathogenesis of AELP is unclear, and there is no safe and effective specific drug. The purpose of this study is to explore the biological processes, signal pathways and key proteins involved in AELP through proteomics, bioinformatics and polymerase chain reaction, so as to deepen the study of the pathogenesis of AELP.
Methods
The experimental rats were randomly divided into 2 groups: experiment group (inhaled 0.5 ml/kg of sewing machine oil) and control group (inhaled 0.5 ml/kg of normal saline). Collect the proteins in the upper lobe of the right lung of mice for proteomic sequencing to obtain the expression data, use the differential analysis software MaxQuant to screen the differentially expressed proteins (DEPs), and use the bioinformatics analysis method to carry out gene ontology function (GO), Kyoto Encyclopedia of genes and genomes (KEGG) analysis and protein-protein interaction (PPI) network construction for DEGs, Eleven key proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, DEFB4, F3, MK167, SLC39A4, LIMD1 and GJA1) were detected by Reverse-transcription polymerase chain reaction (RT-PCR) for validation.
Results
A total of 1253 DEPs were obtained after comparing the data of the experimental group and the control group with the proteome, including 843 up-regulated proteins and 410 down-regulated proteins. Through the functional analysis of GO and KEGG, it is found that these DEPs mainly participate in the regulation process of integrin binding, proteoglycan binding, chemokine receptor binding, receiver regulator binding, and cytokine activity, and are significantly enriched in proteoglycan binding and other signal pathways. PPI network construction was carried out for DEPs to screen out proteins with high correlation, such as ACTN3, CX3CR1, CCR3, AGT, MYLPF. 11 proteins were verified by RT-PCR，compared with the control group, 9 proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, MK167, SLC39A4, LIMD1 and GJA1) were significantly up-regulated in the experimental group.
Conclusion
Our findings identified that PADI4, IGF2, UHRF1, DEFB4 and GJA1 proteins may be potential diagnostic biomarker of AELP.
Inequality, Diversity, Institutions and Social Cohesion: Unveiling the Importance of Access to Opportunities
Authors: Akram Shahla , Perviaz Zahid
Published: September 2023

This study explores the complex relationship between inequality of opportunities, institutions, and social cohesion. Existing literature is employed to assess the influence of access to opportunities in forming social cohesion, taking into account factors of inequality such as economic class, gender, geography, political affiliation, and social group membership. Regression models and panel data analysis are used to quantify the impacts of different varieties of inequality on social cohesion. Results of the study demonstrate the negative effects of inequality of opportunities on social cohesion, thus reinforcing the importance of tackling inequality to create a more harmonious society. The limitations of the study are discussed, in addition to avenues for further research, and policy implications are elucidated, with a focus on the importance of implementing measures counteracting inequality and encouraging equitable access to opportunities in order to augment social cohesion. This study contributes important insights into the integration of inequality, institutions, and social cohesion, providing policymakers and stakeholders with a comprehensive overview of the issue.JEL classification:D31, D63, O11, Z13, C31
Role of the NLRP3/caspase-1/GSDMD signaling pathway in dopaminergic neurons during Japanese encephalitis virus infection
Authors: Guo Xiaoyan , Li Jiahuan , Lu Siyuan , Huang Zhiwei , Cheng Guofu , Hu Xueying , Zhang Wanpo , Gu Changqin
Published: September 2023

Background: Japanese encephalitis virus (JEV) is a highly neurotropic virus that can enter the central nervous system after high levels of peripheral replication, causing severe neuroinflammation. JEV targets dopaminergic neuron-rich areas such as the thalamus, midbrain, and striatum, causing pyroptosis. Pyroptosis, which is a novel mode of programmed cell death, plays an important role in infection by other flaviviruses, but whether it plays a role in JEV-infected neurons has not been confirmed.
Methods: In this study, the damaging effect of JEV infection on dopaminergic neurons was examined in vivo and in vitro through HE staining, immunohistochemical staining, double immunofluorescence labeling, determination of cytotoxicity, qPCR and western blotting for testing pyroptosis.
Results: Mice infected with JEV showed glial cell activation and proliferation, neuronal degeneration and necrosis, perivascular cuffing, and neuronophilia in brain tissue, and a large number of microglia were significantly activated around the virus-positive signal, as shown by immunofluorescence staining. JEV specifically targeted dopaminergic neurons, activated the nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)/cysteinyl aspartate specific proteinase-1 (caspase-1)/gasdermin D (GSDMD) signaling pathway and induced an inflammatory response. In vitro infection of mouse midbrain dopaminergic neuron cells revealed that JEV significantly replicated in MN9D cells. Infected cells were significantly lesioned at 24 hpi, and the number of lesioned cells increased significantly with time. JEV infection resulted in a gradual increase in LDH release, indicating damage to the cytosol. JEV clearly colocalized with MN9D cells, and apoptosis occurred via an NLRP3/caspase-1/GSDMD-dependent pathway.
Conclusions: These results show that inhibiting pyroptosis can delay motor impairment caused by JEV to some extent and that protecting dopaminergic neurons from viral infection may be an effective strategy for the treatment of JEV with late effects.
Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11
Authors: Cai Rong , Li Xiaohe , Zhang Wenlong , Xing Zhengcao , Hu Shuming , Zhang Geqiang , Wang Tiange , Wang Tianshi , Fan Qiuju , Chen Guo-Qiang , Cheng Jinke , Jiang Xianguo
Published: September 2023

Glioblastoma (GBM) cells require large amounts of iron for tumor growth and progression, which makes these cells vulnerable to destruction via ferroptosis induction. Mitochondria are critical for iron metabolism and ferroptosis. Sirtuin-3 (SIRT3) is a deacetylase found in mitochondria that regulates mitochondrial quality and function. This study aimed to characterize SIRT3 expression and activity in GBM and investigate the potential therapeutic effects of targeting SIRT3 while also inducing ferroptosis in these cells. We first found that SIRT3 expression was higher in GBM tissues than in normal brain tissues and that SIRT3 protein expression was upregulated during RAS-selective lethal 3 (RSL3)-induced GBM cell ferroptosis. We then observed that inhibition of SIRT3 expression and activity in GBM cells sensitized GBM cells to RSL3-induced ferroptosis both in vitro and in vivo. Mechanistically, SIRT3 inhibition led to ferrous iron and ROS accumulation in the mitochondria, which triggered mitophagy. RNA-Sequencing analysis revealed that upon SIRT3 knockdown in GBM cells, the mitophagy pathway was upregulated and SLC7A11, a critical antagonist of ferroptosis via cellular import of cystine for glutathione (GSH) synthesis, was downregulated. Forced expression of SLC7A11 in GBM cells with SIRT3 knockdown restored cellular cystine uptake and consequently the cellular GSH level, thereby partially rescuing cell viability upon RSL3 treatment. Furthermore, in GBM cells, SIRT3 regulated SLC7A11 transcription through ATF4. Overall, our study results elucidated novel mechanisms underlying the ability of SIRT3 to protect GBM from ferroptosis and provided insight into a potential combinatorial approach of targeting SIRT3 and inducing ferroptosis for GBM treatment.
Sums over primes III
Authors: Li Rusen
Published: September 2023

In this paper, we give explicit asymptotic formulas for some sums over primes involving generalized alternating hyperharmonic numbers Hn(p,r,2,1) and Hn(p,r,2,1). Analogous results for numbers with k-prime factors will also be considered.
Multiple geophysical methods for mapping the geometry, leachate and biogas in old waste dumps in Northeast Brazil
Authors: de Vasconcelos Suzan Sousa , Batista Joelson da Conceição , Leal Luiz Rogério Bastos
Published: September 2023

Multiple geophysical methods are efficient for mapping the geometry of old waste dumps, detecting illegally buried waste, identifying areas enriched in leachate and biogas in landfills, and mapping contaminated sites. This paper describes the results of an electrical resistivity tomography (ERT) and magnetometric (MAG) investigation into the extensive dumping of construction and demolition waste installed in a former quarry in Northeast Brazil. Preliminary investigations using a geotechnical survey in the upper portion of the waste massif indicated the occurrence of methane gas, possible leachate at depth, concrete blocks with iron rebar, and even other metals in smaller proportions. The modeling of resistivity and magnetic data was used to delineate volumes containing metal, corresponding to low electrical resistivity values and high magnetic susceptibility. On the other hand, high resistivity measurements and low magnetic susceptibility are associated with gas or compacted and unsaturated terrain. From deep environmental drilling services and excavations in the region under study for the implementation of a subway, it was confirmed that the geophysical anomalies interpretation identified the presence of portions rich in organic matter, with high humidity, inside the dump and the presence of methane, concrete blocks, and ferrous material derived from the demolition of the construction industry.
Duplex Vermiform Appendix Left Behind after Laparoscopic Appendectomy: A Case Report
Authors: Tabatabai Seyyed Jamaluddin , Ebrahimi Abed
Published: September 2023

Background: Duplex appendix, a rare form of vermiform appendix, is seldom encountered. These anomalies are often found incidentally during surgery for other pathologies or occasionally due to their own involvement.
Case presentation: Here, we present a case of a 19-year-old male who initially presented to the hospital with right lower quadrant abdominal pain accompanied by nausea, vomiting, and anorexia. Physical examination revealed tenderness at the McBurney's point and rebound tenderness along with visible guarding. Blood counts showed leukocytosis. Abdominal ultrasound demonstrated an enlarged and thickened appendix. The patient underwent laparoscopic appendectomy, and then, 4 months later, he returned to the hospital with pain in the right lower quadrant, tenderness, and rebound tenderness. A diagnostic laparoscopic surgery was performed, revealing another appendix in the retrocecal area. Ultimately, the patient underwent a repeat appendectomy and was discharged from the hospital without complications after one day.
Conclusions: Acute appendicitis should not be ruled out definitively in a patient with typical clinical manifestations, especially in those with a history of laparoscopic appendectomy. Complete exploration of the cecum during surgery is the only reliable option to rule out appendix anomalies and prevent future medical complications.
Implementing Quantum Prisoner Dilemma via Different Classes of Entangled and Separable States
Authors: Makram-Allah A. T. M. , Abd-Rabbou M. Y. , Metwally N.
Published: September 2023

The possibility of implementing the Prisoner's Dilemma game using different classes of initial states between the players is discussed. Different behaviors of the payoffs have been exhibited, may it increases, decreases or fixed. These behaviors depend on the used initial state either maximum/partial entangled, the chosen entangling gate, and the strategies employed by each player. The increased payoff is displayed when the players adopt different defect strategies, while the fixed payoff is shown when both players apply the same defect strategy. The maximum bounds of the payoff can be attained if the players initially share a maximum entangled state. The maximum /minimum fixed payoff depends on the used entangling gate, where the maximum one is shown if the players send their final states to entangling gate. It is shown that, the nature of the payoff, whether stationary, increasing or decreasing is contingent upon the polarization of the initial state and the used defect strategy. However, if both states are polarized on the same axis direction, the predicted maximum payoff is smaller than that obtained if the initial state are polarized in different polarization of the same axis. Therefore, the initial state settings, entangling parameter and the choice of the defect strategy can be used as control tools to maximize/minimize the obtained payoff.
Late Holocene lake level changes are modulated by centennial hydroclimatic variability of southeastern South America, a case study of Laguna de las Nutrias, Uruguay
Authors: Perez Laura , Cuña-Rodríguez Carolina Celeste , Córdoba Francisco , Bueno Carolina , Crisci Carolina , Puerto Laura del , Azcune Germán , Inda Hugo , García-Rdoríguez Felipe , Piovano Eduardo
Published: September 2023

Laguna de las Nutrias is a small/enclosed shallow lake located within an environmentally protected area under negligible anthropogenic impact in Southeastern South America (SESA). It holds a high-resolution sedimentary record that allowed us to infer the hydrological response to the regional climatic variability during the last 700 year linked to different climate variability modes. We performed 2 mm-µXRF-scanning analyses on an 88-cm long sediment core, which was dated by both 14C and 210Pb techniques. We utilized Ti/Al, Ti/Ca, Fe/Mn, Ti/K, S/Ti, Br/Ti, and Si/Ti as proxies for catchment runoff, lake level, redox conditions, grain size, organic matter, storms/extreme events, and trophic state, respectively. The lowest sedimentation rate, lake level, runoff values, highest trophic state and grain size were recorded between 1360–1800 CE, assigned to the Little Ice Age (LIA), under low humidity conditions related to the weakening of the South American Low-Level Jet (SALLJ). Subsequently, the highest sedimentation rate values, runoff and lake level were recorded up to the present. Concomitant lowest trophic state conditions were inferred and interpreted as dilution processes associated with higher lake levels. This stage was assigned to the onset of the Current Warm Period (CWP), which was characterized by higher humidity conditions leading to the highest sedimentation rate, lake level and runoff values after 1980 CE, associated with the noticeable increase in rainfall during “1970´s climatic shift”. By performing time series analyses, we determined centennial, multi-decadal, decadal, and inter-annual cyclicity in lake level related to the hydroclimatic variability. Furthermore, a high significant positive/negative Spearman correlation was observed between runoff and lake level/trophic state proxies and the El Niño Southern Oscillation (ENSO) reconstruction. ENSO modulates both long and short-term frequency of SALLJ, leading to an increase in rainfall during positive phases, which determined high lake level and runoff and a decreased trophic state due to dilution processes. The reconstructed hydrological variability herein is synchronic with other SESA lacustrine systems and the increased Rio de la Plata discharge, indicating similar long-term limnological responses to the regional climatic patterns.
Defining quality indicators, pharmaceutical care bundles and outcomes of clinical pharmacy service delivery using a Delphi consensus approach
Authors: Canning Martin , Barras Michael , McDougall Ross , Yerkovich Stephanie , Coombes Ian , Sullivan Clair , Whitfield Karen
Published: September 2023

Background Clinical pharmacists perform patient-centred activities to optimise medicines use and prevent harm. Clinical pharmacy quality indicators (CPQI) are often non-uniform and measure individual activities and are not linked to outcomes. Aim To define a consensus agreed pharmaceutical care bundle (PCB) and patient outcome measures across an entire State jurisdiction. Methods A four-round modified-Delphi approach with State Directors of Pharmacy (DOPS) was performed (n = 25). DOPS were asked to rate on a 5-point LIKERT scale the relevance and measurability of 32 inpatient CPQI as well as outcome measures. They also ranked clinical pharmacy activities in order from perceived most to least beneficial. Based upon this ranking, groups of indicators were proposed as PCB, and relevance and measurability assessed. Results Response rate ranged from 40–60% between rounds. Twenty-six individual CPQI reached consensus. The top ranked CPQI was the proportion of patients where a pharmacist documents an accurate list of medicines during admission. There were nine PCB formed consisting between 3 and 7 activities. Only one PCB reached consensus: medication history, adverse drug reaction/allergy documentation, admission and discharge medication reconciliation, medication review, provision of medicines education and provision of a medication list on discharge. Sixteen outcome measures reached consensus. The top ranked were hospital acquired complications, readmission due to medication misadventure and unplanned readmission within 10 days. Conclusion Consensus has been reached on one PCB and sixteen outcomes to monitor clinical pharmacy service delivery. The next step is to measure the extent of PCB delivery and the link to patient outcomes.
Comparison of long-term outcomes between implantable collamer lens V4c and FS-LASIK for myopia correction with presbyopia
Authors: Ye Yuhao , Liu Fang , Zhang Zhe , Niu Lingling , Shi Wanru , Wang Xiaoying , Zhao Jing , Zhou Xingtao
Published: September 2023

Purpose: To compare the long-term safety and efficacy of monovision surgery using implantable collamer lens (ICL) V4c and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) in myopic patients with early presbyopia.
Setting: Eye and ENT Hospital of Fudan University,shanghai, China.
Design: Case series study.
Methods: 48 eyes of 24 patients were included (male/female: 10/14, mean age 45.50±3.82 years). We recorded parameters including mean spherical equivalent, uncorrected distance visual acuity, corrected distance visual acuity, intraocular pressure, presbyopic add power, visual acuity (VA) (logMAR) of dominant eyes (D-eye), non-dominant (nD-eye) eyes, and both eyes (Bi) at 0.4 m, 0.8 m, and 5 m, corneal wavefront aberration, and contrast sensitivity (CS) at the last follow-up (4.5 years, 54.00±9.77 months). Statistical significance was set at p<0.05.
Results: All surgeries were uneventful. The safety indices of ICL V4c group and FS-LASIK group were 1.17±0.30 and 0.98±0.20 (p<0.05), and the efficacy indices were 0.79±0.07 and 0.52±0.07 (p<0.05) respectively. The binocular VA (logMAR) of ICL V4c group and FS-LASIK group at 5.0 m were: 0.02±0.11, 0.18±0.30; 0.8 m: 0.09±0.12, -0.01±0.11; 0.4 m: -0.02±0.06, -0.03±0.08, (p>0.05 at three distances). Compared with ICL V4c group, lower CS was observed at 1.0 cpd in the FS-LASIK group (1.07±0.31 vs. 0.80±0.51, p=0.043).
Conclusions: Implantable collamer lens V4c and FS-LASIK are safe and practicable for correction of myopes with presbyopia. Compared with the FS-LASIK group, the ICL V4c group showed superior CS in nD-eyes in low spatial frequency.
Ni3S2/ZrCoFe-LDH@NF heterojunction catalysts for efficient Overall water Splitting
Authors: Guo Yuchen , Zou Xiangyu , Wei Xueling , Bao Weiwei , Han Jie , Jia FeiHong
Published: September 2023

With the continuous depletion of traditional energy sources, the development of sustainable energy sources has become one of the important tasks today. A two-step synthesis method was employed to construct Ni3S2/ZrCoFe-LDH@NF heterostructured electrocatalysts on nickel grid (NF) in situ. X-ray diffractometer, scanning electron microscope, transmission electron microscope and X-ray electron spectroscopy were employed to characterize the Ni3S2/ZrCoFe-LDH@NF heterostructure, and the HER, OER and total hydrolysis properties of this electrocatalyst were tested in 1 mol·L− 1 KOH electrolyte. It was shown that Ni3S2/ZrCoFe-LDH@NF was a lamellar stacked heterostructure with an overpotential of 330 mV and a Tafel slope of 90.9 mV·dec− 1 at a current density of 100 mA·cm− 2 in the OER reaction and 159.2 mV at a current density of 10 mA·cm− 2 in the OER reaction. Tafel slope was 96 mV·dec− 1, and the catalyst exhibited good structural stability in the 100 h total hydrolysis stability test. The successful construction of this heterostructured electrocatalyst provides a good idea and research basis for the subsequent heterojunction and its application in electrocatalysis.
ML-SocMedEmot: Machine Learning Event-based Social Media Emotion Detection Proactive Framework Addressing Mental Health: A Novel Twitter Dataset and Case Study of COVID-19
Authors: Ismail Leila , Shahin Nada , Materwala Huned , Hennebelle Alain , Frermann Lea
Published: September 2023

Global rapidly evolving events, e.g., COVID-19, are usually followed by countermeasures and policies. As a reaction, the public tends to express their emotions on social media platforms. Therefore, predicting emotional responses to events is critical to put a plan to avoid risky behaviors. This paper proposes a machine learning-based framework to detect public emotions based on social media posts in response to specific events. It presents a precise measurement of population-level emotions which can aid governance in monitoring public response and guide it to put in place strategies such as targeted monitoring of mental health, to react to a rise in negative emotions in response to lockdowns, or information campaigns, for instance in response to elevated rates of fear in response to vaccination programs. We evaluate our framework by extracting 15,455 tweets. We annotate and categorize the emotions into 11 categories based on Plutchik’s study of emotion and extract the features using a combination of Bag of Words and Term Frequency-Inverse Document Frequency. We filter 813 COVID-19 vaccine-related tweets and use them to demonstrate our framework’s effectiveness. Numerical evaluation of emotions prediction using Random Forest and Logistic Regression shows that our framework predicts emotions with an accuracy up to 95%.
The mechanical test as a supplemental decision support tool for the safe removal of an Ilizarov circular external fixator
Authors: Xu Yulin , Liu Jialin , Yang Jinghong , Zhang Tao , Li Zhong , Liu Yanshi
Published: September 2023

Background
Timing the fixator removal is vital for a successful external fixation treatment. The purpose of this study was to determine the effectiveness of axial load-share ratio in vivo as a supplemental decision support tool for the safe removal of an Ilizarov circular external fixator.
Methods
This prospective observational study consists of 83 patients undergoing tibial or femoral lengthening with Ilizarov circular external fixation in our institution, from January 2011 to October 2019. In group Ⅰ (38 patients), the external fixator was removed based on the surgeon’s clinical experience and radiographs from January 2011 to June 2015. In group Ⅱ (45 patients), from July 2015 to October 2019, the supplemental axial load-share (LS) ratio test was accomplished without the knowledge of the clinical results by another medical team. The test was performed by electronically measuring forces in the fixator rods and in a ground force plate. When the LS ratio < 10% was consistent with the conclusion (dense bone formation was achieved in the distraction zone) drawn from the corresponding routine radiographs by the treating surgeon, the external fixator was removed.
Results
There was no statistical significance in demographic data between the two groups (P > 0.05). In group Ⅰ, 4 of the 38 patients suffered refracture (the refracture rate was 10.5%) after fixator removal, and bone union was finally achieved with further intervention by intramedullary nail. In group Ⅱ, 36 patients terminated the external fixation after the first mechanical test, and another 9 patients terminated the external fixation at the subsequent test. None of the 45 patients in group Ⅱ suffered refracture (the refracture rate was 0%). There was statistical significance in the refracture rate between the two groups (P < 0.05).
Conclusions
Adequate assessment of bone regenerate is crucial before removing an external fixator to prevent deformation or refracture. The axial load-share ratio in vivo is a practically quantitative method to supplement radiography and clinical experience for the assessment of regenerate healing, and the axial load-share ratio dropped below 10% is a safe limit for the Ilizarov circular external fixator removal.
Time Series Prediction of Echo State Network Based on Chebyshev Mapping and Strongly Connected Topology
Authors: Xie Minzhi , Wang Qianxue , Yu Simin
Published: September 2023

This paper introduces a novel approach called Chebyshev mapping and Strongly Connected topology for optimization of Echo State Networks (ESNs). To enhance the predictive performance of ESNs for time series data, Chebyshev mapping is employed to optimize the irregular input weight matrix. And the reservoir of the ESN is also replaced using an adjacency matrix derived from a digital domain chaotic system, resulting in a reservoir with strong connectivity properties. Numerical experiments are conducted on various time series datasets, including the Mackey-Glass time series, Lorenz time series, and solar sunspot numbers, validating the effectiveness of the proposed optimization methods. Compared with the traditional ESNs, the optimization method proposed in this paper has higher predictive performance, and effectively reduce the reservoir's size and model complexity.
Daten erfahren und situieren
Authors: Amelang Katrin , Klausner Martina , Sørensen Estrid , Straube Till , Friton Joscha , Queckenberg Robert
Published: September 2023

Der Beitrag nimmt verschiedene Ansätze zu und Erfahrungen mit data walking zum Ausgangspunkt, um sich systematisch mit aktuellen Vorschlägen zur experimentellen Kombination von (Spazieren) Gehen, Beobachten und Daten-/Wissensproduktion auseinanderzusetzen. Dabei wird sowohl auf historische Vorläufer des methodischen Gehens im Bereich der Stadtforschung eingegangen (z.B. Wahrnehmungsspaziergang, Flanieren, Dérive) als auch auf deren Aktualisierung und erweiterten Einsatz im Zuge von digitalen Massendaten. Auf diese Weise wird das Potenzial von Datenspaziergängen zum einen als ein exploratives Instrument in der (partizipativen) ethnografischen Forschung ausgelotet, zum anderen als eine – auch in der Lehre verwendbare – Möglichkeit der Auseinandersetzung damit, was Daten sind, wie sie produziert und erfahrbar werden und wie sie soziale Welten selbst erfassen und mitproduzieren. Dies erlaubt insbesondere die Materialität und Situiertheit von Daten (ihrer Generierung wie Konsequenzen) in Lebenswelten in den Vordergrund zu stellen. Ein Grundrezept für einen Datenspaziergang und mögliche Variationen sowie ein Beispiel runden den Beitrag ab.
Forschungsdatenmanagement in der ethnografischen Forschung
Authors: Imeri Sabine , Klausner Martina , Rizzoli Michaela
Published: September 2023

Der Umgang mit (digitalen) Forschungsdaten ist in den letzten Jahren vermehrt thematisiert und problematisiert worden. Unter dem Begriff Forschungsdatenmanagement (FDM) werden dabei alle Tätigkeiten im sogenannten Datenlebenszyklus subsumiert, von wissenschaftlichen Basisoperationen, wie das Ordnen von Material und Dokumentieren von Arbeitsschritten, über die Vorbereitung von Material für die dauerhafte digitale Archivierung, wie etwa die Erstellung von Metadaten, bis hin zur Kontextualisierung von Forschungsprozessen mit dem Ziel der Bereitstellung von Material für die weitere Benutzung. Auf allen Ebenen stellen sich neben technischen/technologischen und praktischen vor allem rechtliche und ethische Fragen. Der Beitrag formuliert Vorschläge zum verantwortungsvollen Umgang mit Daten/Materialien, die von Studierenden und Forschenden selbst erhoben und ausgewertet werden. Er legt einen Schwerpunkt auf Schritte des FDM, die den Forschungsprozess begleiten, und nimmt insbesondere digital vorliegende ethnografische Feldforschungsdaten in den Blick.
Green Energy Solutions: Vapor Absorption Chiller for Harnessing Engine Jacket Water Waste Heat
Authors: Ali Konain , Shams Hassan , Kamal Ahsan , Umar Mohammad
Published: September 2023

Vapor absorption chiller is a machine that works on a closed-loop system following vapour absorption cycle which can serve as an agent of utilizing the waste heat and is considered a highly economic industrial solution. In this paper, we have analyzed the thermodynamics of the system. We have performed a comprehensive analysis of a vapor absorption chiller using the industry-provided input parameters by utilizing the heat dissipated from the engine jacket water system. A single effect vapor absorption chiller is opted for this study as jacket water temperature falls within it’s operating temperature range. A process flow diagram depicting the vapor absorption cycle for this scenario is made and all the design parameters are calculated accordingly with a software Engineering equation solver (EES). Computer aided graphs are produced in EES that portrays the trend of various important variables relevant to vapor absorption cycle. The co-efficient of performance (COP) of this system came out to be 0.629.
Individuals’ purchase intention of the Sukuk bond: A study on developing economy
Authors: M. Anwarul Islam K. , Islam Serajul , Al-Kharusi Sami , Bashar Bhuiyan Abul , Shariful Haque Md.
Published: September 2023

The Shariah-compliant (Sukuk) bond has been recently introduced in Muslim countries. Sukuk is getting popular among the Muslim population because of its non-interest feature. Thus, this study explores the impact of attitude toward the Sukuk bond, Muslim people’s religiosity, and their subjective norms on the purchase intention of the Sukuk bond in a Muslim developing country: Bangladesh. The study involved 412 individuals who were current customers of Islamic financial products at different financial institutions in Dhaka, Bangladesh. The study used a convenience sampling technique. The study used a survey questionnaire to assess the three independent variables: attitude, religiosity, and subjective norms. The dependent variable was the purchase intention of the Sukuk bond. The statistical software package, SPSS version 29.0, was utilized to test the hypotheses considering a 95% confidence interval. The findings indicate that three independent variables significantly correlated with the dependent variable. The highest correlation was found between subjective norms (r = 0.644) and purchase intention. The regression results suggest that attitude, religiosity, and subjective norms statistically impact the individuals’ purchase intention of the Sukuk bond in Bangladesh. It also shows that consumers’ attitude (β = 0.386) has a greater impact on their purchase intention. Also, consumers’ subjective norms (β = 0.302) have the second highest influence on purchase intention. These variables explain a significant proportion of the variability observed in purchase intention. Also, the t-test shows that male individuals have higher purchase intentions than females.
The mediating role of employee ambidexterity and work engagement for talent management and medical representatives’ performance in Indonesian pharmaceutical companies
Authors: Irfan Nasution Muhammad , Soemaryani Imas , Yunizar  , Hilmiana
Published: September 2023

The business success of pharmaceutical companies in achieving sales targets amid increasingly fierce market competition is highly dependent on the presence of a strong and efficient marketing team. This study aims to explore the impact of talent management on medical representatives’ performance in Indonesia, as well as to analyze the mediation role of employee ambidexterity and work engagement. This study used a quantitative approach involving 167 medical representatives as a sample. Data were collected through questionnaires distributed online and offline. The paper used structural equation modeling-partial least squares (SEM-PLS) for data analysis. The study’s results partially show that talent management, employee ambidexterity, and work engagement can significantly increase medical representatives’ performance (< 0.05). Furthermore, talent management significantly increases employee ambidexterity and work engagement (< 0.05). In addition, an indirect effect was found, where talent management can significantly improve medical representatives’ performance mediated by employee ambidexterity and work engagement (< 0.05). Employee ambidexterity can significantly increase medical representatives’ performance mediated by work engagement (< 0.05). These findings prove that talent management, employee ambidexterity, and work engagement are essential to improve medical representatives’ performance. In addition, these results also can develop more efficient marketing and human resource management strategies in the pharmaceutical industry in Indonesia.
SATISFACTION WITH THE USE OF HEARING AIDS IN EVERYDAY LIFE IN BOSNIA AND HERZEGOVINA
Authors:   Center for Education and Rehabilitation of DHH Students Tuzla, Bosnia and Herzegovina, H. Mahmutovic Esad , Hasanbegovic Husnija ,   University of Tuzla, Departmant of Education and Rehabilitation, Bosnia and Herzegovina, Tomic Marinko ,   Third elementary School, Brcko, Bosnia and Herzegovina
Published: September 2023

The aim of this work was to investigate the qualitative characteristics of hearing aid users (satisfaction with the use of hearing aids in everyday life) and to determine if there are any differences compared to published research in the literature. The sample of respondents consisted of 50 users of hearing aids, aged from 20 to 88 years. The sample was chosen by random selection from a previously selected sample of 398 hearing aid users. A special questionnaire was constructed for the research. The first part of the questionnaire consisted of variables: gender, age, type of hearing impairment, percentage of hearing loss, degree of hearing impairment, time of hearing aid use, and brand of hearing aid. The second part consisted of variables for the assessment of satisfaction with the use of hearing aids, that is, 15 statements to which respondents had to express their views on satisfaction with the use of hearing aids. This part of the questionnaire was carried out by surveying. The results showed that the majority of hearing aid users wear the hearing aid regularly, they benefit significantly from the hearing aid and it helps them in communication. They have no significant problems when using and handling the hearing aid. The variables gender, age, and time of hearing aid use had no statistically significant correlations with the applied set of variables (claims). Attitudes of hearing aid users can be an important factor in determining benefit and satisfaction with hearing aids.
AUDIOLOGIC PROFILE OF PRESCHOOL CHILDREN WITH ADENOID HYPERTROPHY AND HEARING LOSS
Authors:   City General Hospital “8th September”, Department of Otorhinolaryngology, Division of Audiology, Skopje, North Macedonia, Ristovska Lidija , Jachova Zora ,   Ss. Cyril and Methodius University in Skopje, Faculty of Philosophy, Institute of Special Education and Rehabilitation, Skopje, North Macedonia, Kovacevic Jasmina ,   University of Belgrade, Faculty of Special Education and Rehabilitation, Belgrade, Serbia, Hasanbegovic Husnija ,   University of Tuzla, Departmant of Education and Rehabilitation, Bosnia and Herzegovina
Published: September 2023

The aim of the study was to compare pre-treatment and post-treatment pure tone thresholds and tympanometric findings in preschool children with adenoid hypertrophy and hearing loss. This retrospective study included 63 children, 40 males (63.5%) and 23 females (36.5%), aged 4 to 6 years (mean age of 5.5±0.6 years). A total of 21 children (33.3%) had tympanostomy tube placement in addition to adenoidectomy or adenotonsillectomy. All children had mild conductive hearing loss. Pure tone average (PTA) was lower after adenoidectomy and adenotonsillectomy (p<0.0001). Type B tympanogram was predominant before treatment (62.7%), and type A tympanogram after treatment (81%). Preoperative mean PTA in children with adenoidectomy was 28 dB HL and in children with adenotonsillectomy was 27 dB HL. In both subgroups postoperative mean PTA was 16 dB HL. In children with adenoid hypertrophy and conductive hearing loss, hearing thresholds after adenoidectomy or adenotonsillectomy are significantly lower than preoperative hearing thresholds.
SPENDING TIME OUTDOORS: THE EDUCATOR AND THE CHILD
Authors:   Faculty of Educational science, University “Juraj Dobrila”, Pula, Croatia, Kadum Sandra , Segon Emili ,   Kindergarten “Kockica” – Krsan, Croatia
Published: September 2023

Being outdoors allows children to explore, experience natural phenomena, it gives them more space and freedom for development. Educators should arouse children’s interest in nature so that children develop feelings and learn from experience. The research aimed at determining the attitudes and reflections of educators employed in preschool institutions in the Republic of Croatia regarding the attitudes and reflections of educators about being outdoors. The research was conducted on a sample of 351 educators. A measuring instrument designed for the needs of this research was used. The results of the research show that 53% of educators agree or completely agree with the statement that they spend their free time in nature. Furthermore, 35.6% spend up to 6 hours a week walking, recreation, cycling and the like. Regarding the statement which limiting factors prevent going outdoors with children, 58.1% of educators completely agree or agree with the statement. We asked the respondents which other limiting factor they see as an obstacle and 36.9% mentioned the weather. Educators are the ones who decide whether children will spend time outdoors. This affects children’s different experiences because their time outdoors depends on the beliefs and attitudes of their educators.
MOTIVATION OF EMPLOYEES IN THE PUBLIC SECTOR THROUGH ORGANIZATIONAL COMMUNICATION CASE STUDY: VALA MOBILE COMPANY, KOSOVO
Authors:   AAB College, Pristina, Kosovo, Abrashi Gazmend , Reçi Ardita ,   AAB College, Pristina, Kosovo
Published: September 2023

The aim of this study is to reveal the role of internal organizational communication in motivating employees in public service organizations. Data were collected from 249 surveyed employees, in the mobile telecommunications sector in Kosovo, specifically in the Vala mobile company. The collected data was analyzed by using the SPSS system. The study found that information sharing had the greatest effect on employee motivation, followed by employee involvement in decision-making. This paper can be useful for managers and heads to create an organizational culture that promotes both motivation and performance. This paper is unique as it examines the links between organizational communication, motivation, and performance.
SOCIAL PROTECTION AND DEMOCRATIC TRANSITION
Authors: Robaj Avdullah
Published: September 2023

Contemporary states take a variety of measures, ranging from economic, social, cultural, and health to legal ones, to ensure the protection of the individual and the family. Social protection is substantially a form or a field of fulfilment of human needs. Economic assistance, social services and social care are considered social programs which aim to alleviate poverty, eliminate social exclusion, provide social care, enable the reintegration of all individuals, families and groups in need. The Republic of Kosovo, through positive law, has undertaken a series of economic and social measures which ensure the protection of the individual and the family. Social protection in the Republic of Kosovo is not defined by a special law, but it is defined by a package of laws. Thus, currently, in Kosovo there is necessary legal infrastructure for social protection beneficiaries, although not complete in the desired form and quality.
A STUDY ON IMPROVING THE ANXIETY, STRESS AND DEPRESSION LEVEL AMONG PSYCHOSOMATIC PATIENTS THROUGH COGNITIVE LANGUAGE THERAPY
Authors:   Research Scholar, Department of English, School of Social Sciences and Languages, VIT University, Vellore, Monika M. , Suganthan C. ,   Assistant Professor, Institute for Industry and International Programme, VIT University, Vellore
Published: September 2023

The psychosomatic condition affects the hippocampus, temporal role, and parietal lobes of the brain. People with Psychosomatic condition displays poor language skills, higher level of cognitive dysfunction, Memory disorders, Anxiety level, Depression, and stress level. Cognitive language therapy aids learners towards the improvement of anxiety, depression, and stress levels. The sampling method employed in the study is the purposive sampling method. DASS 21 was used to analyze the stress, anxiety, and depression levels before and after the intervention. Cognitive language therapy activities like chunking, embroidery, and identifying errors were given to the learners to reduce the impact of stress, anxiety, and depression among individuals with the psychosomatic condition. The paired t-test in SPSS was performed and from the study findings, it is concluded that the participants displayed a low to medium range of depression after the intervention of cognitive language therapy. Through paired samples test, the significance value for all three pairs (Depression, anxiety, and stress) is 0.000, which is lesser than 0.05. Hence, there is a considerable improvement in depression, anxiety, and stress levels among the participants with the psychosomatic condition as a result of cognitive language therapy intervention.