bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of SARS-CoV-2 acute respiratory viral disease on pregnancy and childbirth
Authors: Turyanytsya S.М. , Korchins’ka O.O. , Sabova A.V. , Baloga O.A. , Petrov V.O.
Published: July 2021

Acute Respiratory Viral Disease SARS - CoV2 - 19 is a new poorly understood disease with an unpredictable course. This article is devoted to the analysis of coronavirus disease and its impact on the condition of newborns.The objective: to identify and investigate the relationship between the detected and revealed SARS-CoV-2 disease and the course of pregnancy and childbirth, dependence on the term in which the diagnosis was established and the consequences of the disease on the course of pregnancy, childbirth and the condition of newborns; to investigate the frequency of detected complications during pregnancy and the peculiarities of the course of pregnancy with combined pathology.Materials and methods. We analyzed 57 stories of pregnancy and childbirth of women who were admitted to the Uzhgorod City Maternity Hospital in the period from May 2020 to January 2021 with a positive result of the SARS-CoV-2 PLR study.Results. Of 57 patients, pregnancy is ongoing in 18 women, and in 39 it has already ended. Of these, 17 (29.8%) women had vaginal physiological childbirth, 21 (36.8%) women had pathological course of labor, of which 16 (28%) patients underwent cesarean section. In general, 34 pregnant women (59.6%) were asymptomatic. A mild course of the disease was in 20 pregnant women (35%), and a severe course was in three patients (5.2%). As a result of 39 births, 41 children were born (two biochorial twins). Of these, 38 children were born alive (92.7%), stillborn - 4 (5.3%). 31 children were born on time (81.6%). The physiological course of the early neonatal period was observed in all full-term newborns. Perinatal loss was observed in three women at 23, 25 and 28 weeks.Conclusions. In children born of mothers with COVID-19, there was no increase in the frequency of the pathological course of the early neonatal period or detected signs of acute respiratory viral infection. It was also found that there is no clear correlation between the severity of the course of coronavirus infection and complications in pregnant women. So, with a relatively easy mile, even an asymptomatic course, threatening complications were observed, since premature detachment of a normally located placenta was evident, but there was no clear correlation between coronavirus, while with a moderate course of pregnancy, we observed a fairly good result of delivery. The sample of patients is very small and does not allow us to draw definitive conclusions about the effect of coronavirus on pregnancy and fetal health. But these data give us the basis for the next studies on the influence of the new SARS-CoV-2 virus on the course of the gestational process, childbirth and the condition of newborns.
Analysis of the results of a retrospective cohort study of the course of pregnancy, childbirth and the postpartum period in high-risk patients to identify factors of unfavorable outcomes and build a predictive model of fetal loss
Authors: Оshovskyy V.I. 
Published: July 2021

Prenatal prognosis is an important part of obstetric care, which aims to reduce fetal and neonatal losses. A differentiated approach to the management of different risk groups allows you to optimize existing approaches.The objective: to identify antenatal factors that correlate with perinatal losses, by conducting a retrospective cohort study of women at high perinatal risk, to build a multifactorial prognostic model of adverse pregnancy outcomes.Materials and methods. A retrospective cohort study was conducted from 2014 to 2016 on the basis of the medical center LLC «Uniclinic», Medical Genetics Center «Genome», Clinic of Reproductive Genetics «Victoria», Kyiv City Maternity Hospital №2. 2154 medical cards of pregnant women from the group of high perinatal risk were selected and analyzed. Of these, 782 pregnant women were included in the final protocol after verification of compliance with the criteria.Results. Cesarean delivery occurred in 115 cases (14.7%). In 50 cases (6.4%) the caesarean section was performed in a planned manner, in 65 (8.3%) – in an emergency. In 39 (5%) cases, the indication for surgical delivery was acute fetal distress. Antenatal fetal death occurred in 11 (1.4%) cases: one case in terms of <34 weeks and <37 weeks of gestation, the remaining 9 cases – in terms of> 37 weeks. Intranatal death of two fetuses (0.3%) was due to acute asphyxia on the background of placental insufficiency. In the early neonatal period, 14 (1.8%) newborns died. Hospitalization of the newborn to the intensive care unit for the first 7 days was registered in 64 (8.2%) cases.The need for mechanical ventilation was stated in 3.96% (31/782) of newborns. The method of construction and analysis of multifactor models of logistic regression was used in the analysis of the relationship between the risk of perinatal losses (antenatal death, intranatal death, early neonatal death) and factor characteristics.Conclusion. Signs associated with the risk of perinatal loss: the presence of chronic hypertension, preeclampsia in previous pregnancies, type of fertilization (natural or artificial), the concentration of PAPP-A (MoM), the concentration of free β-HCG (MoM) in the second trimester, average PI in the uterine arteries in 28–30 weeks of pregnancy, PI in the middle cerebral arteries in 28–30 weeks of pregnancy, episodes of low fetal heart rate variability in the third trimester of pregnancy, episodes of high fetal heart rate variability in the third trimester of pregnancy. The model, built on selected features, allows with a sensitivity of 73.1% (95% CI: 52.2% – 88.4%) and a specificity of 72.7% (95% CI: 69.3% – 75.9%) to predict risk perinatal loss.
The peculiarities of the management of women with endometriosis during pregnancy
Authors: Lakhno I.V.
Published: July 2021

Endometriosis is a significant problem in modern medicine. The prevalence of endometriosis is 10%, it occurs in 38% of women with infertility. For a century, it was believed that pregnancy contributes to the reduction in volume and even the disappearance of foci of endometriosis. Also, the state of «pseudopregnancy» under the influence of combined oral contraceptives was once considered an effective treatment strategy. To date, it is known that decidualization of endometrioid heterotopias not only contributes to their increase in size, but can also provoke bleeding. These changes can mimic ovarian cancer on ultrasonography. Typical complications of endometriosis are enlargement, rupture, or abscess formation.It has been proven that women with endometriosis have an increased relative risk of developing: preeclampsia by 19%; fetal growth retardation by 12%; premature birth by 46%; placenta previa almost threefold; preterm placental abruption by 40%; caesarean section operations by 49%; stillbirth by 27%; postpartum hemorrhage by 5%; spontaneous intra-abdominal bleeding by 24.6 times – only two cases are known in women with endometriosis and no bleeding from the intact peritoneum is known; spontaneous bowel perforation (only 18 cases are known). It has been proven that in pregnant women with endometriosis, the invasion of the extravillous trophoblast into the spiral vessels of the uterus is impaired. However, there is evidence that the endometrioid phenotype is not associated with placental dysfunction and does not increase the risk of developing great obstetric syndromes.Since most of the complications of endometriosis during pregnancy cannot be predicted, any additional interventions are not of use. So, to date, there is no evidence of the need to introduce separate protocols for the management of women with endometriosis during pregnancy. However, there should be an individualization of the approach in each separate case. The given atypical clinical case in a woman with diffuse adenomyosis demonstrates the importance of the problem of predicting various complications of pregnancy and childbirth. Moreover, clinical cases contribute to the continuation of the study of this disease.
Human milk bank in Ukraine – relities and perspectives
Authors: Zahorodnia O.S.  , Bila V.V. , Chernyak I. , Lazo I.I.
Published: July 2021

Premature birth complicates 5 to 8% of pregnancies worldwide. The efforts of the medical world are aimed at improving the care of premature infants, which is much more successful – increasing the proportion of extremely premature surviving infants, improving the health and quality of life of premature infants. Such measures include, in particular, the early start of enteral feeding. It is its early initiation that is complicated by the delay in establishing lactation in the mother. To overcome this contradiction, it is proposed to use donor breast milk, for the procurement and storage of which human milk banks have been created. The objective: to analyze the activities of the human milk bank of the Kyiv Perinatal Center in 2020. Materials and methods. To evaluate the activity of the breast milk bank the main indicators of its work for 2020 were analyzed – the total number of donors, their distribution by age, total milk volume, average milk volume per woman, duration of donor milk to newborns. Results. During 2020, 65 donors took part in the breast milk donation program, who received 8,603 portions of milk and 8,220 portions were given to recipients for consumption. It is established that the main source of information for breast milk donors is the staff of the Perinatal Center, and therefore – the main motivation to participate in the program is the desire to help in the care of premature infants. The main pool of recipients (67.1%) are patients of the intensive care unit. A small part of the donor milk was consumed by patients of the postnatal care department and the second stage of nursing. Among patients receiving donor breast milk in the intensive care unit, preterm weight categories of 1000–1499 g (49.3%) and 1500–1999 g (32.7%) dominated. Conclusions. 1. The main source of information about the breast milk donation program is the staff of the Perinatal Center of Kyiv (32.3%), which determines the main motivation of the study participants. The prospect of developing the idea of ​​breast milk donation in Ukraine is popularization in the media in order to expand the audience and encourage women who have given birth in other obstetric facilities. 2. The main pool of DHM recipients in the Perinatal Center of Kyiv are premature patients of the intensive care unit. The largest proportion of patients receiving DGM were in the weight category of 1000–1499 g. The average duration of consumption of DGM by patients in this department is 6.5±0.9 days.
Preterm labor: issues of prognosis, prevention and management (Literature rewiew)
Authors: Petrenko Ye. , Strubchevka K.P.
Published: July 2021

Preterm labor is the leading cause of neonatal mortality and the most common cause for antenatal hospitalization. Approximately 15 million babies are born preterm each year worldwide. Of those, one million babies die before the age of 5, which is 18% of all deaths of children at this age. 35% of early and late neonatal mortality (under 28 days of age) is associated with preterm birth.The pathophysiology of preterm labor includes at least four major pathogenetic mechanisms. The studied components of this process are premature activation of the maternal or fetal hypothalamic-pituitary-adrenal system, inflammation or infection, decidual hemorrhage and pathological overdistension of the uterus. The diagnosis of preterm labor is based on the determination of concomitant regular uterine contractions and cervical changes. Vaginal bleeding and/or rupture of the amniotic membranes only increase the likelihood of this diagnosis. To improve the accuracy of diagnosis and assess the potential risk of preterm birth in the presence of symptoms in pregnant women, it is proposed to use such diagnostic tests as transvaginal ultrasound to measure cervical length; detection in vaginal fluids of fetal fibronectin (fFN), phosphorylated protein-1, which binds insulin-like growth factor (IGFBP-1), placental alpha-microglobulin, the ratio of insulin-like growth factorebinding protein 4 (IBP4) and sex hormoneebinding globulin (SHBG) – PreTRM-test.Correct identification of women in the true preterm labor allows performing appropriate actions, which results in better outcomes for the newborn. These are using of corticosteroids to prevent respiratory distress syndrome (RDS) of the newborn; prevention of group B streptococcal infection; magnesium sulfate to protect the baby’s nervous system; transportation to the institution of the third level of perinatal care, which can provide a newborn with appropriate medical care. Preventative and therapeutic measures for women, which have a high risk of preterm labor, include taking progesterone, cervical cerclage and an application of obstetric pessary.
The effect of hormone therapy on the condition of the mammary glands in women with menstrual disorders of endocrine origin
Authors: Gladenko S. E.
Published: July 2021

The objective: to study the effect of stimulating hormone therapy on the condition of the mammary glands depending on the initial endocrine status of women with menstrual disorders in the background and after ovulation stimulation.Materials and methods. The study selected a group of 130 patients (n=130) of reproductive age (mean age 27±2,3 years), which by the nature of menstrual disorders are divided into 2 subgroups: 1 subgroup (n=57) – women with regular menstrual rhythm and insufficiency of the luteal phase (ILP), 2 subgroup (n=73) – women with secondary amenorrhea and oligomenorrhea on the background of chronic anovulation. All patients complained of no pregnancy for an average of 4±1,2 years. After a comprehensive assessment of the reproductive system and hormone-dependent organs, women received the proposed treatment with estrogen-progestogen drug, bromocriptine and ovulation stimulation with clomifene citrate.Results. During the preparatory (diagnostic) phase of the study it was found that in 1 subgroup in 89,5% of patients with concomitant diseases of the pelvic organs and only endocrine disorders of the ILP type in 10,5%. In women of 2 subgroup, the frequency of combined pathology was 23,3%, and endocrine disorders – 76,7%. These results confirmed the need for laparoscopic and hysteroscopic examination of all patients with infertility in addressing the issue of ovulation stimulation. After short cycles (3 months) of monophasic estrogen-progestogen therapy, 31,6% of patients with ILP and 17,1% with anovulation had a positive effect on reducing the incidence of pain in the mammary glands, with the most sensitive to therapy were patients with diffuse forms of fibrocystic disease with a predominance of cystic and glandular components. When resuming biphasic ovulatory cycles with clomifene citrate stimulation, only 5,7% of women complained of breast pain during the first 1–2 cycles. No additional foci in the subgroups were detected, and previously diagnosed fibroadenomas did not increase.Conclusion. Analyzing the obtained data, a positive effect of different types of hormone therapy on the condition of the mammary glands in patients with menstrual and reproductive dysfunction, in particular with diffuse forms of fibrocystic disease with a predominance of cystic and glandular components, is structures most sensitive to normal progesterone levels. Despite the lack of negative dynamics on the background of ovulation stimulation and restoration of normal mammary gland structure after therapy in women with menstrual disorders of endocrine origin, menstrual cycle regulation and dynamic monitoring of the mammary glands are shown to prevent the development of hyperplastic processes.
Detection of Pyrogens in Hormonal Implants Using the LAL Test
Authors: Neugodova N. P. , Shapovalova O. V. , Sapozhnikova G. A. , Stepanyuk E. O.
Published: July 2021

The State Pharmacopoeia of the Russian Federation, 14th edition states that implants are a sterile dosage form, and have to be tested for pyrogens. However, it does not provide details on how the test should be performed for this dosage form.

The aim of the study was to develop a LAL test procedure for detection of bacterial endotoxins (BE) in implants, using the example of a goserelin product.

Materials and methods: BE extraction from the implant surface into an aqueous medium was performed with subsequent BE detection in the extract by turbidimetric kinetic test. The implant was then dissolved in dimethyl sulfoxide, and the obtained goserelin solution was tested for BEs using the gel-clot test.

Results: the analysis of the Russian and foreign pharmacopoeial approaches to pyrogenic substance detection in hormonal implants helped to develop two sample preparation procedures for determination of BE content (in the extract and the implant solution). It was demonstrated that the BE content in the water extract did not exceed 0.01 EU/mL and was less than 0.07 EU per implant. The BE content in the implant solution was less than 8.3 EU per 1 mg of goserelin, which is almost eleven-fold lower than the theoretically-derived limit.

Conclusions: the authors developed two test procedures for BE detection in hormonal implants using the LAL test, which could be included in manufacturers’ product files. The first procedure involves testing of the water extract from the implant surface and establishes the BE limit of no more than 20 EU/product. The second procedure involves complete dissolution of the implant in dimethyl sulfoxide and establishes the limit of not more than 97.22 EU per 1 mg of goserelin.
Effect of Co-Inoculation of Multi-Traits Bacteria Based Bio-Formulations on the Growth, Yield and Enzyme Activities of Tea
Authors: CAKMAKCI Ramazan , AKÇURA Sevim , ERAT Mustafa
Published: July 2021

The objective of this study was to evaluate possible effects of mineral fertilizer (NPK), one commercial and three N2-fixing, P-solubilizing and/or ACC deaminase-containing bacteria based bio-fertilizers in triple strains combinations (BF9: Bacillus megaterium 47/9+ Paenibacillus macquariensis RC696 + Pseudomonas fluorescens 9/7; BF10: Bacillus megaterium RC665+ Paenibacillus macquariensis RC382 + Pseudomonas fluorescens 9/7; BF11: Bacillus simplex RC64 + Pseudomonas putida 3/10 + Burkholderia pyrrocinia RC134) were evaluated for their growth and enzyme activities of tea under acidic soil conditions, in three years. The experiment was conducted in a completely randomized design with six treatments and four replicates (each having five tea bushes). Bio-fertilizers formulations stimulated overall plant growth, including leaf area, green leaf yield, chlorophyll content and enzyme activities in tea. In addition, inoculation with bacterial formulation, activities of the different enzymes like glutathione reductase, glutathione S-transferase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, polyphenol oxidase, peroxidase, urease, 5-dehydroshikimate reductase, and alcohol dehydrogenases also changed. The selected effective acid-tolerant multi-traits bacteria based bio-formulations could play an important role in understanding the plant tolerance and adaptation to stress, processing technology, and may contribute to the concept of the quality of tea products. This study shows that these indigenous beneficial rhizobacteria isolates have the potential to be used as microbial inoculation or bio fertilizer to stimulate tea crop growth and are promising for sustainable tea cultivation.
Aktarlardaki Bitkisel Droglar ve Kullanımları: Isparta Örneği
Authors: KARA Nimet , ALTINTAŞ Halil , ŞİRİKÇİ Bekir Sıtkı , GÜL Mevlüt
Published: July 2021

Araştırma, Isparta’da aktarlarda halk arasında kulanılan bazı ilaç ve baharat bitkilerinin kullanım alışkanlıklarını incelenmek amacıyla yürütülmüştür. Veriler, toplam 16 aktar (15 erkek, 1 kadın) ve 200 tüketici ile yüz yüze görüşülerek elde edilmiştir. Elde edilen sonuçlara göre, en çok drog satın alımı yapan yaş grubunun 30 ile 45 arasında olduğu ve en yaygın sağlık probleminin diyabet ve tansiyon olduğu belirlenmiştir. Tüketicilerin %42.5’i lise, %35’i lisans, %15.5’i ortaokul, %5’i lisansüstü ve %2’i ise ilköğretim mezunudur.

Isparta’da aktarların 350’den fazla ürün çeşidine sahip oldukları, en fazla talep gören bitkilerin ise ıhlamur, adaçayı, kekik ve kuşburnu olduğu saptanmıştır. Aktarların %75.0’ının tüketicilere tedavi tavsiyesi vermediklerini ve %25.0’ının ise tedavi tavsiyesinde bulunduklarını beyan etmişlerdir. Tüketicilerin %84’ü alternatif tıp ile ilgili bilgilerinin olmadığını ve edinilen bilgilerin ise internet ve televizyondan (%71.2) öğrendiklerini belirtmişlerdir.

Araştırmada, bilinçli bir işletmecilik ve tüketim alışkanlığının olmadığı, tıbbi ve aromatik bitkiler ve ürünleri uzmanların önerileri doğrultusunda kullanılmalıdır. Ayrıca droglar daha uygun koşullarda muhafaza edilmeleri ve son tüketim tarihlerinin yazılarak tüketiciye sunulması gerektiği soncuna varılmıştır.
Türkiye'deki Altın Kist Nematodu (Globodera rostochiensis) Popülasyonlarının Morfolojik Tanımlanması
Authors: EVLİCE Emre , YATKIN Gökhan , ÖCAL Atilla , GÜVEL Civan , TOKTAY Halil
Published: July 2021

Patates kist nematodları (PKN) Altın kist nematodu olarak isimlendirilen Globodera rostochiensis (Wollenweber, 1923) Skarbilovich, 1959 ve Beyaz kist nematodu olarak isimlendirilen G. pallida Stone, 1973, tüm dünyada hemen hemen tüm patates alanlarında önemli verim kayıplarına neden olan yaygın türlerdir. Önemli karantina etmenleri olan PKN’nın doğru ve hızlı teşhisi mücadelesi açısından çok önemlidir. Bu iki türün oluşturduğu risk nedeniyle, Türkiye'de bu etmenlerin varlığı sertifikalı ve yemeklik patates alanlarında ulusal survey programı kapsamında taranmaktadır. Çalışma kapsamında Niğde, Nevşehir, İzmir, Afyon ve Bolu illerine ait 10 farklı lokasyondan elde edilen PKN popülasyonlarına ait kist ve ikinci dönem larvalar morfolojik ve morfometrik karakterlerine göre teşhis edilmiştir. Çalışma İzmir ili hariç diğer illerdeki G. rostochiensis popülasyonlarının ilk detaylı morfolojik ve morfometrik verilerini içermektedir. Çalışma sonucunda popülasyonların tamamı G. rostochiensis olarak teşhis edilmiştir. Türkiye’deki bulaşık alanların tamamını kapsayacak şekilde ilk kez yapılan bu çalışmayla ülkemizdeki G. rostochiensis popülasyonlarının morfolojik olarak teşhisinin yapılabildiği, ölçüm değerlerinin referans literatürlerle uyumlu olduğu belirlenmiştir. Ancak rutin analizlerde tüm dünyada en önemli karantina etmenlerinden biri olan Patates kist nematodlarının teşhisinde morfolojik ve moleküler yöntemlerinin bir arada kullanılmasının daha doğru olacağı düşünülmektedir.
Portakal Kabuğu Yağı ve Nar Çekirdeği Yağı ile Zenginleştirilen Diyetlerin Bıldırcınların Verim Performansı, Yumurta Kalitesi ve Bazı Kan Parametreleri Üzerine Etkileri
Authors: SELÇUK Şebnem , ŞENGÜL Turgay
Published: July 2021

Bu çalışma, bıldırcınların diyetlerine ilave edilen portakal kabuğu yağı (PKY) ve nar çekirdeği yağının (NÇY), bıldırcınlarda, canlı ağırlık, yem tüketimi, yemden yararlanma oranı, yumurta verimi, yumurta kalitesi, yumurta sarısı yağ içeriği ve yağ asidi kompozisyonu, oksidatif stres ve bazı kan parametreleri üzerine etkilerini ortaya koymak amacıyla yapılmıştır. Çalışmada, diyetlere 2 farklı düzeyde (0.5 ve 1 g/kg) PKY ve NÇY ilave edilmiştir. Her biri 3 tekerrürlü olmak üzere, kontrol, 0.5 g/kg PKY, 1 g/kg PKY, 0.5 g/kg NÇY ve 1 g/kg NÇY olmak üzere toplam 5 grup teşkil edilmiştir. Denemede, 8 haftalık yaşta 180 adet dişi bıldırcın kullanılmıştır. Bıldırcınlar, deneme süresince %20 ham protein ve 3000 kcal/kg ME içeren diyetlerle serbest olarak yemlenmişlerdir. Elde edilen sonuçlara göre, diyete yapılan PKY ve NÇY katkılarının, verim performansı, yumurta kalitesi ve kan parametreleri üzerine önemli olumsuz etkileri görülmemiştir. Buna karşılık, yumurta verimi, yumurta ağırlığı, kabuk kalınlığı, sarı ağırlığı, sarı rengi, HDL, AST, LDH, MDA ve yumurta sarısı kolesterol düzeyi gibi özellikler bakımından dikkati çeken iyileşmeler gözlenmiştir. Oksidatif stres hasarını gösteren MDA, tüm muamele gruplarının yumurta sarılarında önemli oranda düşüş göstermiştir. Yem katkıları, palmitik asit, stearik asit ve miristik asit gibi doymuş yağ asitlerinin düzeylerinde önemli azalmaya; oleik asit, gama linoleik asit, heptadekanoik asit gibi yağ asitlerinde ise artışa neden olmuştur. Kontrol grubuna oranla, muamele gruplarının doymuş yağ asitleri düzeyinde önemli azalmalar, PUFA/SFA oranında ise önemli artışlar görülmesi, her iki yem katkısının da özellikle yumurtanın besleme değeri açısından yararlı etkilerini göstermesi bakımından önemlidir.
Effects of Supplementation With Iron, Selenium and Magnesium on Galleria mellonella Cell-Mediated Immune Responses
Authors: KAYA Serhat , GÜNDÜZ Bülent
Published: July 2021

Immune responses play a key role in the survival of all living things. Intake of inorganic materials is of critical importance in living organisms because of their participation in metabolism and some component of cells. Iron (Fe), magnesium (Mg) and selenium (Se) were selected for this study because of their participation in critical constituents of cells, such as nucleic acids and enzymes in living organisms, and their indirect and direct effects on immunity. Although the separate effects of these inorganic materials are known, there is no study on their combined effects. Galleria mellonella, which is used as a model organism, is frequently used in evaluating of effects of human pathogens due to its various properties. Total hemocyte counts and encapsulation-melanization responses are the most commonly observed parameters when examining the immune responses of this model organism. In our study, the effects of the selected inorganic materials added in the ratio of 0.1%, 0.25%, 0.5% and 1% in the nutrient content of Galleria mellonella on the immune responses of this organism were investigated. As a result of the study, it was found that only 0.25% of the doses increased the hemocyte count and that the other doses significantly decreased compared to the control group. However, it was determined that 0.5% and 1% feeding caused a significant decrease in both hemocyte count and encapsulation-melanization responses. According to our findings, the nutrients which have over a certain dose by inorganic substances have negative effects on immunity.
Posof Yöresi Elmalarında Periyodisiteye Kısmen Eğilim Gösteren Tipler
Authors: OSMANOĞLU Abdullah , BALTA Fikri
Published: July 2021

Bu araştırma, Posof ilçesi ve köylerinde, mevcut genetik varlığı içerisinde, elma ağaçlarının periyodisiteye eğilim durumlarını araştırmak üzere yapılmıştır. Yörenin elma çeşit varlığı içerisinde değerlendirilmeye alınan elmalar arasından 18 genotip periyodisiteye eğilimi bakımından ‘kısmen periyodisite gösteren tipler’ olarak isimlendirilmiştir.

Araştırmanın sonuçlarına göre; değerlendirilmeye değer görülen 111 elma genotipinden 18’inde (POSOF-01, POSOF-15, POSOF-16, POSOF-22, POSOF-23, POSOF-36, POSOF-46, POSOF-55, POSOF-59, POSOF-64, POSOF-65, POSOF-74, POSOF-81, POSOF-90, POSOF-91, POSOF-95, POSOF-104 ve POSOF-109) düzenli meyve alınımı ‘kısmen’ olmuştur. Bu tiplerinde; ortalama olarak, meyve eti sertliği 9.02–23.7 lb, meyve ağırlığı 114.8–252.8 gr, meyve eni 66.1–92.3 mm, suda çözünebilir kuru madde miktarı ise %9.8–13.4 olarak belirlenmiştir. Tiplerde, hasada en erken Ekim ayının birinci ve en geç ikinci haftasında başlanırken, tam çiçeklenmeden hasada kadar geçen gün sayıları 140-166 gün arasında değişiklik göstermiştir.
Aspek Stilistika dan Nilai Moral dalam Novel Ayah, Aku Rindu Karya S. Gegge Mappangewa
Authors: Ruslan Ruslan , Sugono Dendy , Suendarti Mamik
Published: July 2021

Tujuan penelitian ini adalah mendeskripsikan aspek stilistika dan nilai moral dalam novel Ayah, Aku Rindu karya S. Gegge Mappangewa. Metode yang dipakai dalam penelitian ini adalah metode deskriptif. Fokus penelitian ini adalah novel Ayah, Aku Rindu karya S. Gegge Mappangewa. Subfokus yang dikaji adalah stilistika dan nilai moral dalam novel tersebut. Data yang diperoleh dianalisis dengan lima tahapan, yaitu membaca, memberi tanda, mencatat, mendeskripsikan, dan menyimpulkan. Simpulan penelitian ini adalah 1) Terdapat 102 temuan bermajas yang terdiri atas majas perbandingan, penegas, pertentangan, dan sindiran dengan rincian: (a) majas perbandingan dengan 69 temuan; (b) majas penegas dengan 23 temuan; (c) majas pertentangan dengan 9 temuan; (d) majas sindiran dengan 1 temuan. 2) Terdapat 146 temuan yang mengandung nilai moral. Nilai moral tersebut terdiri atas tiga jenis hubungan manusia, yaitu (a) hubungan manusia dengan diri sendiri, yaitu 48 temuan; (b) hubungan manusia dalam lingkup sosial dan lingkungan, yaitu 84 temuan; dan (c) hubungan manusia dengan Tuhan, yaitu 14 temuan.

 

Kata Kunci: Novel Ayah, Aku Rindu, Stilistika, Majas, Nilai Moral.
Pengaruh CAR, ROA dan NPF Terhadap Pembiayaan Murabahah
Authors: Putri Anggia , Wirman Wirman
Published: July 2021

Peneliti ini bertujuan untuk mengetahui bagaimana dampak Capital Adequacy Ratio (CAR), Return On Asset (ROA) dan Non Performing Financial (NPF) terhadap Pembiayaan Murabahah pada Bank Usaha Syariah yang terdaftar di Bank Indonesia periode 2015-2019. Populasi dalam penelitian ini ialah seluruh Bank Usaha Syariah yang sudah teregistrasi di Otoritas Jasa Keuangan (OJK) dengan periode 2015- 2019. Sampel penelitian ini berjumlah 11 Bank Usaha Syariah  dengan menerapkan metode purposive sampling. Data yang diterapkan dalam penelitian ini yaitu data sekunder berupa laporan keuangan yang didapat dari situs masing-masing Bank yang menjadi sampel penelitian. Metode yang diterapkan pada penelitian ini yakni analisis kuantitatif yang menggunakan regresi berganda. Hasil penelitian menunjukkan bahwa CAR dan NPF tidak berpengaruh terhadap pembiayaan murabahah sementara variabel ROA berpengaruh terhadap pembiayaan murabahah. Sedangkan secara simultan dari ketiga variabel CAR, ROA, dan NPF berpengaruh secara signifikan terhadap pembiayaan murabahah.
ANALISA SENTIMEN TERHADAP REVIEW PRODUK KECANTIKAN MENGGUNAKAN METODE NAIVE BAYES CLASSIFIER
Authors: Sari Dita Novita , Sari Dita Novita , Adelia Firda , Rosdiana Fita , Butar Belsana Butar , Hariyanto Muhadi
Published: July 2021

Saat ini produk kosmetik sudah menjadi kebutuhan utama kaum wanita yang merupakan target dari segi jenis maupun brand sebuah kosmetik. Namun tidak semua kosmetik memiliki kualitas yang baik sesuai dengan kebutuhan konsumen, maka dari itu agar tidak salah memilih produk, disediakan website yang berbentuk opini yang sudah mencoba produk tersebut, dan agar tidak memakan waktu lama untuk melihat review dari berbagai opini yang ada di website, oleh karena itu analisis sentimen merupakan salah satu solusi mengatasi masalah untuk mengelompokkan opini atau review kosmetik dengan cara pengklasifikasian review tersebut menjadi opini positif atau negatif secara otomatis. Data review yang akan diuji merupakan emoticon dan kata sifat yang sudah diberi label secara manual. Dengan menggunakan metode Naïve Bayes memiliki kelebihan yaitu sederhana, cepat dan memiliki akurasi yang tinggi. Nilai akurasi yang dihasilkan akan menjadi tolak ukur untuk mencari model penguji yang terbaik untuk kasus klasifikasi sentimen. Dengan menggunakan RapidMiner diketahui bahwa 110 data negatif terklasifikasi 85 data dinyatakan negatif sesuai prediksi dan 25 data diprediksi positif tetapi hasilnya negatif, begitu juga 110 data positif terklasifikasi 92 sesuai prediksi dan 18 data diprediksi negatif tetapi hasilnya positif. Berdasarkan hasil perhitungan nilai akurasi yang didapatkan sebesar 80.45%.
SISTEM PENDUKUNG KEPUTUSAN PENENTUAN PENERIMA BEASISWA DENGAN METODE SIMPLE ADDITIVE WEIGHTING DI SMPN 19 TANGERANG
Authors: Kartiko Bayu Aji
Published: July 2021

In determining scholarship recipients in schools manually, errors often occur causing inefficient management of scholarship data in terms of time and the absence of clear criteria for how students can obtain scholarships. To anticipate that mistakes do not occur, a Decision Support System is needed. One method that can be used is the Simple Additive Weighting (SAW) method. The data collection method used was the observation method to the school and the interview method with the related teachers regarding the scholarship acceptance. In this research, system development is carried out using the Waterfall method. And for system testing used Black-box Testing. The system design uses the Unified Model Language (UML), which includes usecase diagrams, activity diagrams, sequence diagrams and class diagrams. Then the program implementation uses the PHP programming language and MySQL database. This application will also display the value, criteria, alternatives and then a ranking of the scholarship recipient determination process. With this decision support system, the school will get the results of who is entitled to receive the scholarship. Keywords: Decision Support System, Scholarship, Simple Additive Weighting (SAW) Method, Unified Model Language (UML).
O Cuidado da Família À Pessoa Renal Crônica Em Diálise Peritoneal
Authors: Negreiros Daniella Marques , Furtado Angelina Monteiro , Gonçalves Cristiano Batista , Ribeiro Ítalo Arão Pereira , Lima e Silva Laianny Luize , Ferreira Anderson de Assis , Araújo Andréa da Silva , Batista João Paulo Silva
Published: July 2021

Objetivou-se analisar as evidências científicas sobre o papel da família no cuidado a pessoa com insuficiência renal crônica em diálise peritoneal. Estudo do tipo revisão integrativa, o qual foi utilizado as seguintes bases de dados: Banco de Dados em Enfermagem (BDENF) e Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS), ambas via Biblioteca Virtual em Saúde (BVS); e biblioteca virtual: Scientific Eletronic Library Online – SciELO. Para busca dos estudos utilizou da estratégia da descrição adaptada de PVO. Para essa pesquisa foram utilizados os seguintes descritores controlados: "Insuficiência Renal Crônica", "Diálise Peritoneal", "Tratamento domiciliar", "Família", "Resultado do tratamento", "Eficácia”. Os artigos estudados foram agrupados em 3 categorias: na realização da diálise em si, no apoio emocional e social na colaboração financeira. A participação da família é marcada pelo envolvimento ativo no tratamento, pela responsabilização da qualidade de vida, adesão ao tratamento e incentivadora do esquema terapêutico.
Gestão do cuidado a usuários com feridas crônicas na Atenção Básica
Authors: Ribeiro Denis Fernandes da Silva
Published: July 2021

Objetivo: Caracterizar o perfil dos usuários portadores de lesões crônicas e o perfil de cuidados implementados a estes sujeitos por uma Unidade Básica de Saúde com Estratégia Saúde da Família. Metodologia: Pesquisa documental, descritiva, exploratória e de abordagem quantitativa em que se estudou dados referentes ao processo de cuidado a portadores de feridas crônicas em uma Unidade Básica de Saúde. Foram analisados, retrospectivamente, dados de agosto de 2017 a julho de 2018. Resultados: O publico era predominantemente idoso e discretamente feminino, no qual havia uma alta carga de doenças crônicas. Do total, 56,7% apresentavam lesões vasculares, que em 46,7% exibiam tecido de granulação e 63,3% manifestava infecção ou colonização. O cuidado foi realizado em 96,7% dos casos nos consultórios e na sala de curativos da unidade de saúde. A maior parte das coberturas especiais (62,5%) esteve ausente em algum intervalo de tempo no período estudado. Conclusões: Evidenciou-se a necessidade de fortalecimento do papel da atenção básica no manejo das lesões crônicas, bem como a relevância do abastecimento efetivo de insumos para redução da fragmentação do cuidado.
Análise histórica de diagnósticos de enfermagem relacionados a feridas e lesões de pele
Authors: E Sousa Francisca Graslânia Félix , Ponte Vanessa Aguiar , Brandão Maria Girlane Sousa Albuquerque , Silva Alan Sidney Jacinto , Barros Lívia Moreira , Araújo Thiago Moura
Published: July 2021

Objetivo: Analisar historicamente mudanças nos diagnósticos de enfermagem relacionados às feridas e lesões de pele. Método: Pesquisa documental, realizada de abril de 2017 a abril de 2019. Fizeram parte da amostra os diagnósticos de enfermagem: Integridade da Pele Prejudicada, risco da Integridade da Pele Prejudicada, Integridade Tissular Prejudicada, Risco da Integridade Tissular Prejudicada, Risco de Lesão por Pressão da Taxonomia II da NANDA de 2001 a 2018. Resultado: A principal mudança foi nas características definidoras de Integridade da pele prejudicada. A definição de Risco da integridade da pele prejudicada passou por quatro mudanças. O diagnóstico Integridade tissular prejudicada modificou a definição e fatores relacionados. Houve alteração no diagnóstico Risco de Úlcera por pressão para Risco de lesão por pressão. Conclusão: As mudanças em terminologias e acréscimo de informações nos diagnósticos foram realizadas no intuito de favorecer a sistematização da assistência de enfermagem e fomentar a melhor identificação dos diagnósticos.
The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface
Authors: Turovsky Yaroslav A. , Gureev Artem P. , Vitkalova Inna Yu. , Popov Vasily N. , Vakhtin Alexey A.
Published: July 2021

A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism (BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of BDNF when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities.
Sex differences in structural brain asymmetry of children with autism spectrum disorders
Authors: Li Cuicui , Ning Mingmin , Fang Pinyan , Xu Haibo
Published: July 2021

Previous studies have confirmed the sex difference of gray matter asymmetry in typically developing controls and the abnormal gray matter asymmetry in autism spectrum disorders. However, whether and how sex differences of gray matter asymmetry exist in autism spectrum disorders remains studied. This paper analyzes the above issues and explores correlations between gray matter asymmetry and autistic symptoms. Data from 72 children (36 males and 36 females) with autism spectrum disorders and 72 typically developing-controls (36 males and 36 females) between 8 and 14 years were included and obtained from the autism brain imaging data exchange repository (autism brain imaging data exchange I and autism brain imaging data exchange II). The voxel-based morphometry approach was used to assess gray matter asymmetry in T1-weighted brain data, and gray matter asymmetry was quantified as asymmetry index. A 2 × 2 analysis of covariance was used to identify asymmetry index differences among the four groups. Pearson correlation analysis was performed for asymmetry index values extracted from the clusters with significant differences between the four groups and autistic symptoms (social impairments, communication difficulties, and restricted, repetitive behaviors) measured by the revised autism diagnostic interview scale. Results showed that specific brain regions showed significant main effects for diagnosis in which autism spectrum disorders patients had more leftward asymmetry than typically developing-controls for the parahippocampal gyrus and the postcentral gyrus; specific brain regions showed significant main effects for sex in which females showed more rightward asymmetry for the middle temporal gyrus, inferior frontal gyrus, angular gyrus, and postcentral gyrus and minor rightward asymmetry for the superior frontal gyrus than males; significant diagnosis × sex interaction effects were identified in the angular gyrus and middle occipital gyrus. Pearson correlation analysis showed that males with autism spectrum disorders had a positive association between the asymmetry index value in the middle occipital gyrus and more significant verbal impairment measured by the revised autism diagnostic interview (r = 0.387, p = 0.026). The asymmetry index value in the parahippocampal gyrus was positively associated with more severe social impairment in females with autism spectrum disorders (r = 0.422, p = 0.020). We identified that the sex difference of gray matter asymmetry in children with autism spectrum disorders is qualitative rather than quantitative, which is relatively novel. Our findings provide the theoretical basis for conducting separate studies and using sex-specific diagnostic methods and treatments for males and females children with autism spectrum disorders.
The change index of quantitative electroencephalography for evaluating the prognosis of large hemispheric infarction
Authors: Tian Jia , Liu Li-Dou , Zhou Yi , Zhang Zhe , Pu Yue-Hua , Liu Da-Cheng , Guo Li
Published: July 2021

A growing number of studies have demonstrated the role of quantitative electroencephalography in assessing brain function in neuro-intensive care units. Still, few studies have examined patients with large hemisphere infarction. Thirty patients with large hemisphere infarction were included in this preliminary study, and the patients were divided into the death group (twelve patients) and survival group (eighteen patients). Electroencephalography monitored the patients, and a computerized tomography inspection was performed. The quantitative electroencephalography of the alpha-beta/delta-theta ratio change index was calculated and used to predict the prognosis of early large hemisphere infarction patients. The relationship between three months modified Rankin Scale, and alpha-beta/delta-theta ratio change index was analyzed. The death group had negative changes for alpha-beta/delta-theta ratio change index (-0.0140 ± 0.0193), while there was an opposite trend in the survival group, the median is 0.004 (-0.0067, 0.0137). The death group’s brain function decreased more severely and rapidly than the survival group (P = 0.004). The highest diagnostic value (AUC value 0.815, P < 0.001) was observed when the alpha-beta/delta-theta ratio change index dropped and exceeded -0.008. The area under the GCS curve was 0.674, but its predictive ability was low (P = 0.094). The correlation analysis result showed that the 3-month modified Rankin Scale was negatively correlated with the alpha-beta/delta-theta ratio change index (r = -0.489, P = 0.006). The alpha-beta/delta-theta ratio change index is considered an indicator for predicting the prognosis of large hemisphere infarction. Therefore, the alpha-beta/delta-theta ratio change index may be a reliable quantitative EEG parameter that predicts the early prognosis of patients with acute large hemispheric infarction.
Effect of combined yoga and transcranial direct current stimulation intervention on working memory and mindfulness
Authors: Danilewitz Marlon , Gao Sihaoyu , Salehinejad Mohammad Ali , Ge Ruiyang , Nitsche Michael A , Vila-Rodriguez Fidel
Published: July 2021

Transcranial direct stimulation, a non-invasive neurostimulation technique for modulating cortical excitability, and yoga have both respectively been shown to positively affect cognition. While preliminary research has shown that combined transcranial direct stimulation and meditation may have synergistic effects on mood and cognition, this was the first study to explore the combination of transcranial direct stimulation and yoga. Twenty-two healthy volunteers with a regular yoga practice were randomized to receive either active transcranial direct stimulation (anodal left, cathodal right dorsolateral prefrontal cortex) followed by yoga intervention or sham transcranial direct stimulation followed by yoga intervention a double-blind, cross-over design over two separate intervention days. Outcome measures included working memory performance, measured with the n-back task and mindfulness state, measured with the Toronto Mindfulness Scale, and were conducted offline, with pre-post assessments. Twenty participants completed both days of the intervention. Active transcranial direct stimulation did not have a significant effect on working memory or levels of mindfulness. There was a significant placebo effect, with better performance on day 1 of the intervention, irrespective of whether participants received active or sham transcranial direct stimulation. There was no significant difference between active versus sham transcranial direct stimulation concerning working memory performance and mindfulness, which may be accounted by the small sample size, the transient nature of the intervention, the fact that yoga and transcranial direct stimulation concerning were not conducted simultaneously, and the specific site of stimulation.
Sleep actigraphic patterns and cognitive status
Authors: Buratti Laura , Camilletti Roberta , Pulcini Alessandra , Rocchi Chiara , Viticchi Giovanna , Falsetti Lorenzo , Baldinelli Sara , Fiori Chiara , Silvestrini Mauro
Published: July 2021

We performed an actigraphic assessment of sleep characteristics in healthy subjects and patients with cognitive impairment. Thirty subjects were included and classified into controls (10 subjects), mild cognitive impairment (10 patients) and mild-to-moderate Alzheimer’s disease (10 patients). Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Participants had a 7-day actigraphic record. Sleep parameters collected were time in bed, total sleep time, sleep efficiency, sleep latency, wakefulness after sleep onset, number of awakenings, and mean motor activity. Significant differences between mild cognitive impairment and controls patients were found for sleep latency (p = 0.05); Alzheimer’s disease patients had significantly worse scores for Pittsburgh Sleep Quality Index (p = 0.01), time in bed (p = 0.001), total sleep time (p = 0.04), sleep latency, sleep efficiency, motor activity (p = 0.0001) and wakefulness after sleep onset (p = 0.001) compared to controls. When comparing Alzheimer’s disease and mild cognitive impairment, differences were significant for sleep latency (p = 0.01), wakefulness after sleep onset (p = 0.004), sleep efficiency, number of awakenings and motor activity (p = 0.0001). In addition to showing a high prevalence of sleep alterations in subjects with cognitive impairment, our data suggest that they are evident from the earliest stages of cognitive decline. Further studies are needed to assess whether early correction of sleep alterations can positively influence the evolution of cognitive impairment. The opportunity to provide clinically meaningful information with a simple assessment of sleep characteristics based on actigraphy suggests that wider use of the approach in patients with cognitive decline should be considered.