bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role and Impact of Agricultural Machinery Service Provider for Rural Community Development Case in Indonesia
Authors: Winarno Kodrad , Sulastiyah Amie , Rusliyadi Muhamad
Published: September 2021

Agricultural machinery plays a strategic role in achieving Indonesia’s agricultural development goals. It is considered capable of increasing agricultural production and productivity through managing cultivation, harvest and post-harvest activities. The government has facilitated farmers with agricultural machinery through farmer groups and joint-farmer groups by encouraging them to form Agricultural Machinery Services Provider (AMSP). The purpose of this research is to describe the agribusiness management of AMSP, in terms of organizational, technical and economic aspects. This research was conducted from June 2017 to October 2017 in four districts, namely Bantul, Sleman, Gunung Kidul and Kulon Progo. Purposive sampling was used as a sampling method in this research. There were 32 respondents; 12 from AMSP, 16 from farmers groups, 4 private agricultural machinery service providers. The data analysis used was descriptive and qualitative data analysis. This research concluded that management of AMSP from an organizational perspective in the 4 districts is compatible with the Permentan Nomor 25 2018 guidelines regarding growth and development of AMSP. From the technical aspect, most of the operational agricultural machinery is 2-wheeled and 4-wheeled tractors. From the economic aspect, Earnings are distributed based on 40:60 ratio where AMSP earns 40% and the operator earns 60%. In relation to the cost of land cultivation, AMSP can earn between RP. 600.000,- – Rp. 800.000,- and the operator can earn Rp. 900.000,- – Rp. 1.200.000,-.
Manifestações Patológicas em Sistemas Construtivos de Paredes de Concreto – Estudo de Caso em Obras de Interesse Social
Authors: Coutinho Felipe Dias de Abreu , Carneiro Laísa do Rosário Souza , Santos Janaíne Conceição , Poggiali Flávia Spitale Jacques
Published: September 2021

O notável crescimento da construção civil brasileira no começo dos anos 2000 impulsionou o uso de sistemas construtivos industrializados, como por exemplo, as paredes de concreto. Tal sistema permite elevada produtividade e racionalização da obra. Por outro lado, necessita de mão-de-obra qualificada e equipamentos específicos, o que torna o processo mais complexo que a construção tradicional. O presente trabalho identificou e analisou as manifestações patológicas de duas obras que utilizaram o sistema de paredes de concreto moldadas in loco. Inicialmente, foram levantadas as causas dos problemas, seguindo-se ao diagnóstico e à proposição de possíveis tratamentos. As seguintes anomalias foram identificadas: descolamento do revestimento cerâmico das paredes internas, fissuras horizontais nas paredes, fissuras a 45º na parte inferior das paredes, fissuras em cantos de janelas e segregação superficial do concreto. Verificou-se que a principal origem das anomalias se encontra na etapa de execução. Assim, destaca-se a necessidade de realização de um rigoroso treinamento da mão-de-obra, acompanhado de uma contínua fiscalização dos serviços. A etapa de concretagem deve ser previamente planejada, sendo fundamental a participação síncrona dos diferentes agentes envolvidos. É importante ater-se às seguintes recomendações: dosagem adequada do concreto usinado, garantia do bom funcionamento da bomba lança, concretagem integral de uma parede antes de prosseguir para a concretagem de outros elementos e posicionamento do mangote a uma altura inferior a 2m durante a concretagem. Destaca-se, ainda, o posicionamento adequado da armadura de reforço nos cantos das janelas e portas e a preparação do substrato para aplicação de revestimento cerâmico, a partir da lavagem com detergente e escova de aço. Este estudo visa contribuir para a disseminação de conhecimentos práticos, corroborando-se com a prevenção de anomalias em obras futuras.
Les réformes du droit français de la responsabilité civile
Authors: Mazeaud Denis
Published: September 2021

L'auteur estime que la réforme du droit de la responsabilité, s’impose, si tant est que l’on croit aux vertus de la codification, à savoir l’accessibilité, la prévisibilité et la stabilité du droit. Parce qu'il existe un très embarrassant contraste entre le Code civil et le droit positif de la responsabilité. Le Code doit être sensiblement restauré et rénové. Seule une intervention législative permettra une réforme d’envergure dont droit a manifestement grand besoin, entre autres, pour inscrire dans le long terme et avec la précision requise, les évolutions nécessaires en vue d’une rénovation profonde et pérenne de notre droit de la responsabilité.
Les règles de la responsabilité civile pour le dommage causé par le salarié à un tiers
Authors: Skupień Dagmara
Published: September 2021

Ce chapitre présente les règles de la responsabilité de l’employeur pour le dommage causé par le salarié à un tiers (1) ainsi que les règles de la responsabilité du salarié pour son propre fait (2).
DOI 10.19163/1994-9480-2020-4(76)-127-130 MANAGEMENT OF COMPLICATED PREGNANCY IN GRAVIDA WITH DISTURBED UTERINE CONTRACTIONS
Authors: Mironenko D. M , Demina T. N , Zheleznaya A. A
Published: September 2021

A disturbed uterine contraction activity is a basic stage in the pathogenesis that result in a pathological or abnormal labor. Now some new ways f uterine activity were discovered that may be helpful to find promising targets for future medications. This article presents a clinical case of pregnancy with an abnormal labor and describes diagnostic and corrective methods for contractile activity disturbance making an impact to purinergic system. A way to predict a protracted pregnancy and special considerations for induced labor management were suggested. The reported clinical case indicates usefulness of protracted pregnancy prevention and introducing of the developed series of preventive measures to a wide practice aiming to obtain healthy newborns and to reduce pathological labor occurrence.
PSYCHOPHYSIOLOGICAL STABILITY OF WORKING POPULATION OF PRE-RETIREMENT AGE (BY EXAMPLE OF VOLGOGRAD REGION)
Authors: Khvastunova I. V. , Sevriukova G. A , Ushakova I. A , Schmidt S. A , Akhundova R. E
Published: September 2021

In the working population of pre-retirement age in Volgograd and the Volgograd region, studies of psychophysiological stability, individual features of the organization of the nervous system and the functional state of the sensorimotor sphere were performed. The majority of persons of the surveyed individuals living in areas with hypo comforted conditions shown decrease in psychophysiological stability. In pre-pensioners living in areas with precomfort conditions, involutionary mental depression manifests itself more significantly than if the aging body is affected by negative exogenous factors of a complex socio-ecological situation. The development of situational symptoms must be considered when follow-up surveys of people over 50 years old.
HEPARAN SULFATES EXPRESSION IN SURGERY MATERIAL OF OVARIAN ENDOMETRIAL CYSTS
Authors: Aidagulova S. V , Timofeeva Yu. S , Volchek A. V , Kuleshov V. M , Marinkin I. O
Published: September 2021

The expression of heparan sulfate proteoglycans in eutopic and heterotopic endometrium in patients with ovarian endometriosis was studied using the method of immunohistochemistry. The simultaneous increase in the level of expression of core proteins of all studied heparan sulfate proteoglycans and the content of heparan sulfate in pathological tissues indicates the important role of glycosylated molecules in the pathogenesis of ovarian endometriosis.
Siberian Expeditions of Employees of the IDR FCTAS RAS
Authors: Fomin Maxim
Published: September 2021

In the framework of the implementation of phase a result, the RFBR grant "modeling scenarios of spatial development of Siberia and the Far East of Russia 2030: features of the settlement system" (2019-2021) in may-June 2021 employees go FCTAS RAS wounds were conducted three surveys поездкиvв regions of Western Siberia (in 2020 two expeditions in 4 of the subject in the far East, and in 2019, four expeditions in 10 regions of Siberia and the Far East).
Trends in Internal Migration in The Republic of Belarus
Authors: Dragun Maria
Published: September 2021

The article presents the main trends of internal irrevocable migration in the Republic of Belarus. The normative legal acts regulating the studied problems are considered, in particular, information is provided on the approval of the project “Village of the Future”; a development plan for regions lagging behind in socio-economic development; measures to promote the development of entrepreneurial activity in rural areas. The assessment of the existing internal migration flows in the Republic of Belarus over the past twenty years has been carried out by studying and analyzing official statistical data posted on the website of the National Statistical Committee of the Republic of Belarus. The intensity coefficient of intra-republican migration is calculated, which allows determining the dynamics of the migration movement, regardless of changes in the population. In order to identify the position of a particular region and the city of Minsk relative to the country as a whole, calculations of the migration attractiveness index were carried out. The population movements between territorial units and in the directions (“city – city”, “city – village”, “village – city”, “village – village”) are analyzed. It is concluded that in the study period, migration flows from city to city prevail, and the outflow of population from village to city continues, but since 2016, the intensity of urban growth at the expense of the rural population has decreased, which is a new trend. Migration relations between the regions of the Republic of Belarus have been studied and analyzed, illustrations have been developed that clearly reflect the population flows within the country. Based on the analysis, the conclusion is formulated that internal migration in the Republic of Belarus has a centripetal character, since the main share of migration flows falls on the metropolitan-central region. It is revealed that this direction of internal migration flows correlates with the index of migration attractiveness (hereinafter-IMP). It is established that the population growth of the city of Minsk and the Minsk region occurs at the expense of all regions (Brest, Vitebsk, Gomel, Grodno,Mogilev); in turn, the city of Minsk is also replenished at the expense of the population that originally arrived in the Minsk region. The author has recorded another trend – the migration increase to the capital has decreased over the past five years. Based on the results of the study, the author came to the conclusion that further work is needed to expand and consolidate the set of measures aimed at improving the socio-economic living conditions in the regions and rural areas.
EVALUATION OF CHRYSOPERLA CARNEA COMPLEX AND COCCINELLID PREDATORS AS BIOCONTROL AGENTS OF RICANIA SPECULUM (WALKER, 1851) (HEMIPTERA RICANIIDAE)
Authors: MAZZA GIUSEPPE , BINAZZI FRANCESCO , MARRACCINI DANIELE , BONCOMPAGNI LUCA , SABBATINI PEVERIERI GIUSEPPINO , ROVERSI PIO FEDERICO , GARGANI ELISABETTA
Published: September 2021

Ricania speculum is an alien insect feeding on several host plants belonging to several families, including important vegetables, crops, ornamental plants, wild plants as well as trees. For the first time, recently, Chrysoperla sp. and coccinellid beetles have been observed preying on this species in the field on Citrus sp. and Laurus nobilis plants. The main purposes of this work were to evaluate the possible predation capability of these groups of insects and determine their prey preference in laboratory trials. In the choice trials, R. speculum nymphs were paired in a confined space and exposed for 24h to single predators: Ch. carnea complex and to the coccinellids Cryptolaemus montrouzieri, Adalia bipunctata, Coccinella septempunctata, and Propylea quatuordecimpunctata. Specimens of Aphis rumicis, an aphid frequently found on her baceous plants, were used as a control prey. In the cage trials, a single Ch. carnea complex second-instar larva was placed into a jar containing a tomato plant with ten R. speculum nymphs. In the choice trials, a high mortality percentage of both preys was observed with the Ch. carnea complex, while in those with Coccinellids only high A. rumicis mortality was reported. In the cage trials, 13% mortality of R. speculm was recorded after 24h while after 72h and 168h prey mortalities reached 18% and 25%, respectively. The results of the study showed that larvae of the Ch. carnea complex could be potential predators of R. speculum, while coccinellids do not seem promising predators of this alien species.
Features of medical support of physical training and mass sports events in the Armed Forces of the Russian Federation
Authors: Maslyakov V. V. , Savchenko A. V. , Zhilyaeva A. L.
Published: September 2021

Introduction. Physical training is the most important element of the combat readiness of the troops, its goals and objectives are defined by the Manual on Physical Training in the Armed Forces of the Russian Federation. The solution of these tasks should contribute to the formation of military personnel's readiness to endure extreme physical and mental stress during the preparation and conduct of combat operations. Comprehensive provision of physical training in the troops requires the hard work of various services, including the medical service.

The purpose of the study. Identify problematic issues of medical support for physical training and sports events in the Armed Forces of the Russian Federation and identify ways to solve them.

Materials and methods. The article uses the materials of the work of medical and nursing teams in the medical provision of physical training of units of the Southern Military District from 2016 to 2019. Additionally, the data of an in-depth medical examination of the personnel of some units of the district subordination for 2018 were used.

Results and discussion. When analyzing the work of visiting medical and nursing teams during the medical support of passing the standards for physical training, a number of problematic issues were identified. First, there are always military personnel who regularly do not engage in physical training and during the delivery of standards make excessive efforts and work at the limit of their capabilities. Secondly, some exercises are very dangerous, either in terms of injuries or the likelihood of developing complications from the cardiovascular system. All this applies to the medical support of the competition. As an example, the championship of the Armed Forces of the Russian Federation in fire and rescue sports, held from 3 to 6 September 2019 in Rostov-on-Don on the territory of the garrison fire brigade, is given. The program of the competition included passing the obstacle course, climbing the training tower, extinguishing the fire, etc., all very traumatic. Therefore, for the medical support of these competitions, a medical and nursing team of the resuscitation profile was allocated on a reanimobile with specialized stowage, respiratory and oxygen equipment.

Conclusion. It is necessary to strictly monitor the correctness of the definition of the group of physical training and the gradual increase in physical activity in order to avoid complications and further progression of diseases or even deaths in military personnel. It is impossible to approach formally the conduct of an in-depth medical examination of military personnel.
The Primary Care Research Landscape and its Relationship with Clinical Practice: A Scientometric Analysis
Authors: Apitz Salomé , Fontoura Pedro
Published: September 2021

Introduction: It is unclear if research published in primary care journals aligns with the broad spectrum of problems managed in primary care practice. The aim of this study was to analyse publication trends concerning the burden of medical conditions reported in primary care journals, and to compare these findings with the burden of problems seen in clinical practice, in order to identify research gaps.Material and Methods: Scientometric tools were used to analyse 9956 articles of primary care journals indexed in MEDLINE. Through keyword analysis, a relations map was built. Literature review and a primary care database were used to identify active problems and reasons for visiting a family physician. Rankings and frequencies of research output and conditions were compared.Results: Keyword analysis identified five clusters of publication trends: cardiovascular conditions and conditions related with unhealthy lifestyles; mental disorders; infections; oncology and health management. By comparing publications with clinical problems, the fields of orthopaedics, endocrinology/metabolism, gastroenterology/hepatology, dermatology, ophthalmology, and the respiratory system show the biggest gaps. Through the relations map, more concrete potential research topics were identified such as palliative care, chronic pain, insomnia, antibiotic prescribing, burnout, osteoporosis, osteoarthritis, and COVID-19.Discussion: The present study acknowledged potential research and publication gaps in Primary Care journals. The findings might help to direct continuing medical education and help with guideline development.Conclusion: The distribution of publications in primary care journals is distinct from the burden of problems faced in clinical practice and reasons for visiting a family physician. The use of scientometric tools to identify publication trends and their comparison with common problems could be a strategy to identify areas with research gaps in primary care.
O dirigismo laico: D. Pedro II e o projeto imperial
Authors:   Universidade Federal de Minas Gerais, Biscardi Afrânio
Published: September 2021

Este estudo traça um breve esboço sobre a maneira pela qual a historiografia trata o mecenato artístico de D. Pedro II, sua relação com os projetos construtores da incipiente nação e a imagem criada do próprio monarca. Considera ainda a ruptura do academismo romântico face aos padrões neoclássicos nas artes plásticas.
Modos de negra e modos de branca: o retrato Baiana e a imagem da mulher negra na arte do século XIX
Authors:   Universidade Estadual de Campinas, Bittencourt Renata
Published: September 2021

Ensaio sobre a pintura conhecida como “Baiana“ do acervo do Museu Paulista da Universidade de São Paulo, buscando estabelecer relações com os costumes culturais de seu contexto de origem, bem como a iconografia do século XIX, com foco na representação pautada por questões de gênero e etnicidade.
Por um natural da normalidade: a problematização do conceito de realismo na arte alemã do entre-guerras (1919-1938)
Authors:   Universidade Estadual de Campinas, Bortulucce Vanessa Beatriz
Published: September 2021

Texto apresentado no II Encontro de História da Arte.
A necessidade do retorno à obra no caso brasileiro
Authors:   Universidade Estadual de Campinas, Cardoso Renata Gomes
Published: September 2021

Texto apresentado no II Encontro de História da Arte.
Arte na escola: a construção da história da arte a partir do leitor
Authors:   Universidade Estadual Paulista, Costa Maria Luiza Calim de Carvalho , Biondo Guiomar Josefina ,   Universidade Estadual Paulista
Published: September 2021

Entendemos a imagem como um texto, ou seja uma trama, uma rede, que emana sentido, pensamos, então, no espectador de uma obra imagética como um leitor. Descartamos a linha do tempo como caminho de aproximação do leitor à obra, buscamos trajetos constelativos ou rizomáticos, propomos que cada leitor trace seu caminho de leitura e com isso tenha uma participação ativa na construção do sentido.O trabalho do professor envolve sensibilidade e conhecimento: em um primeiro momento como instigador para gerar o interesse ou a necessidade, e num segundo momento como alimentador do repertório, oferecendo outros textos verbais ou não-verbais para que o aluno trace seu caminho de leitura.
Corpo na arte, body art, body modification: fronteiras
Authors:   Universidade Estadual de Campinas, Silva Priscila Ramos da
Published: September 2021

Tão freqüentemente associado à produção artística atual, o termo corpo na arte é, para muitos, uma incógnita. Afinal, do que se trata falar, simultaneamente em arte e corpo? A junção das duas palavras parece, à primeira vista, mais confundir do que esclarecer. Com freqüência, a arte do corpo dos anos 1990/2000 é confundida duas outras manifestações em que o corpo é o suporte da criação: a body art dos anos 1960/70 e o a body modification, fenômeno que compreende a realização de piercings, tatuagens, escarificações e outras intervenções corporais. No que se refere à arte contemporânea, um estudo aprofundado sobre a questão do corpo deve se deter, de início, sobre duas questões metodológicas fundamentais: a primeira é a definição o do próprio termo corpo na arte. A segunda, a delimitação das fronteiras entre os três campos de ação distintos: a arte do corpo atual, body art e a body modification. Estas serão as questões discutidas nesta comunicação.
O gasto social do governo de Mato Grosso do Sul (2013-2017)
Authors: Barbosa Francis Régis Gonçalves Mendes , Ferrera de Lima Jandir
Published: September 2021

O objetivo desta pesquisa foi quantificar e analisar o gasto social do governo de Mato Grosso do Sul no período de 2013 a 2017. Na mensuração do gasto social, foram contempladas as funções Educação, Cultura, Saúde, Saneamento Básico, Trabalho, Assistência e Previdência Social, Habitação e Urbanismo, Segurança Pública, Judiciária e Essenciais à Justiça, Gestão Ambiental, Ciência e Tecnologia e Transportes. Os resultados demonstraram que o gasto social do governo de Mato Grosso do Sul aumentou sua participação relativa na receita total, na receita corrente líquida e na despesa total, em termos reais e per capita, a despeito do deficit orçamentário do governo. A prioridade do governo estadual foi o gasto social, associado a externalidades positivas, o que contribuiu para a melhoria da qualidade de vida da população dessa unidade federativa.
Determinants of Bank-Tunisian SMEs Funding in a Context of Information Asymmetry
Authors: Romdhane Syrine Ben , Jebali Emna
Published: September 2021

This paper explores the determinants of access to finance for small and medium enterprises (SMEs) in the context of asymmetric information. Our sample consisted of 250 Tunisian SMEs financed by Arab International Bank of Tunisia, broken down by sector of activity, size and region. The results of multiple linear regressions showed that size, interest rate, trade credits and profitability have a significant influence on the total volume of credit. The bank considers the size of commercial and industrial SMEs, and those located in the District of Tunis and the Center-East, as a positive signal when considering a loan. The bank also considers high interest rates when considering loans to commercial SMEs, microenterprises and SMEs located in the District of Tunis. As far as innovation is concerned, the results showed that service SMEs, micro-enterprises and SMEs located in the District of Tunis and in the Center-East, find it difficult to get a credit. It is interesting to note that the bank neglects liquidity issues and the net worth of the SME in its financing decision, which contradicts the theoretical assumptions. Finally, we conclude that bank's financing of Tunisian SMEs is characterized by conditions dominated by the problem of asymmetric information.
Modelling the Global Prevalence of COVID-19: An Econometric Approach
Authors: Adekunle Wasiu , Oyolola Feyisayo , Atolagbe Oluwafemi , Abdulbasit Ademola , Odugbemi Taiwo , Ashiru Yusuff
Published: September 2021

Nearly all economies of the world suffered from the sudden outbreak of the coronavirus pandemic emanating from Wuhan City of China to the rest of the world. A number of studies have been conducted to investigate the drivers of the spread of the viral infection. We differ from existing studies by employing a cross-sectional quantile regression approach to uncover socio-economic conditions that are instrumental in the spread of COVID-19 in Africa, Asia, America and Europe. Across the continents, we observed that life expectancy, the size of the aged population and spending on the health sector have significant impacts on the spread of COVID-19. We also noted the specific roles of out-of-pocket spending, net migration and tourism attraction for Africa, America and Europe, respectively, in driving the viral spread. We therefore draw policy implications in terms of the need for improved spending on health sector across continents and the need to intensify health checks for travelers and immigrants, and also the need to emphasize regular check-ups for all individuals across continents since current realities have shown that no age-group is spared of contracting the viral infection.
Growth and Hierarchy of Cities in Algeria: Application of the Rank-Size Rule
Authors: Bousmaha Ahmed , Zeraib Salah , Benhassine Nassira , Kouba Yacine
Published: September 2021

The objectives of this paper are to analyze the urban growth and urbanization phenomenon in Algeria. Two processes that originated respectively by the expansion of existing urban areas and the process of urbanization that took place between 1954 and 2008, a period marked by significant economic, social and political changes in Algerian society. Our analysis was mainly based on the Algerian general census of population and habitat (2008) and on the application of rank-size distribution of cities according to Zipf’s rule. This study revealed that in Algeria, the urban system is particularly marked by the dramatic expansion of small cities. Indeed, the development of small towns, through the transition from rural to urban and the residential loosening of large cities have influenced the trend towards the balance of the urban system in Algeria. Results revealed also how the "primatial" city is undergoing profound economic and social changes at the national level. These changes are most often imposed from the top as part of land-use planning policy. This study provides some insights into the demographic dynamics of cities and the evolution of urban hierarchies in Algeria, through the comparison of the different rank-size distributions of Algerian cities in space and time. Our results suggest that land-use planning strategies are the only policies capable of influencing the future of the Algerian urban system.
A Novel Method to Stimulate Lymphatic Clearance of Beta-Amyloid from Mouse Brain Using Non-invasive Music-Induced Opening of the Blood-Brain Barrier with EEG Markers
Authors: Semyachkina-Glushkovskaya Oxana , Khorovodov Alexander , Fedosov Ivan , Pavlov Alexey , Shirokov Alexander , Sharif Ali Esmat , Dubrovskii Alexander , Blokhina Inna , Terskov Andrey , Navolokin Nikita , Evsukova Arina , Karandin Georgy , Elovenko Dariya , Tzoy Maria , Ageev Vasily , Agranovich Ilana , Telnova Valeria , Tsven Anna , Saranceva Elena , Iskra Tatyana , Kurths Jürgen
Published: September 2021

The lymphatic system of the brain meninges and head plays a crucial role in the clearance of amyloid-β protein (Aβ), a peptide thought to be pathogenic in Alzheimer’s disease (AD), from the brain. The development of methods to modulate lymphatic clearance of Aβ from the brain coild be a revolutionary step in the therapy of AD. The opening of the blood-brain barrier (OBBB) by focused ultrasound is considered as a possible tool for stimulation of clearance of Aβ from the brain of humans and animals. Here, we propose an alternative method of non-invasive music-induced OBBB that is accompanied by the activation of clearance of fluorescent Aβ (Fαβ) from the mouse brain. Using confocal imaging, fluorescence microscopy and magnetic resonance tomography, we clearly demonstrate that OBBB by music stimulates the movement of Fαβ and Omniscan in the cerebrospinal fluid and lymphatic clearance of Fαβ from the brain. We propose the extended detrended fluctuation analysis (EDFA) as a promising method for the identification of OBBB markers in the electroencephalographic (EEG) patterns. These pilot results suggest that music-induced OBBB and the EDFA analysis of EEG can be a non-invasive, low cost, labelling free, clinical perspective and completely new approach for the treatment and monitoring of AD.
Characteristics of new coronavirus infection in patients with acute myeloid leukemia
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Ivanov D.O. , Petrenko Yu.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Reznik V.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Nasyrov R.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Timchenko V.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Subbotina M.D. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Chernova T.M. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Bannova S.L. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Kondratyev G.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Krasnogorskaya O.L. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Paneakh M.B. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Fedotova E.P. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Kaplina T.A. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation
Published: September 2021

In the Russian Federation, the proportion of children among all cases of new coronavirus infection is up to 8.6%. Mild forms are registered in 80% of cases, severe – 0.2%, as a rule, in children of the first year of life. The majority of deaths were recorded in children with an unfavorable background: 75% of those who died had one concomitant pathology, 45% – two or more. The problem of severe course and fatal outcomes from COVID-19 in children with comorbid pathology, for example, with various forms of leukemia, remains relevant. Severe infectious complications of bacterial nature are observed in 70–80% of sick children, viral and fungal genesis, respectively, in 4–12% and 18–20%. Myeloblastic leukemia is one of the factors that predispose to a severe course of COVID-19 and an unfavorable outcome. The article presents a clinical observation of the course of a critical form of a new coronavirus infection in a young child with acute myeloblastic leukemia. The layering of COVID-19 contributed to a sharp deterioration of the underlying disease. Despite the highly organized treatment process with the use of modern technologies, the child had a rapid deterioration of the condition with a fatal outcome. Key words: COVID-19, children, acute myeloblastic leukemia, pancytopenia, fatal outcome
Skin care in children with atopic dermatitis
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Goncharova O.V. , Komissarova O.A. ,   Children's City Clinic Nо 15, Moscow Healthcare Department, Moscow, Russian Federation, Kameldenova D.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Baryshnikova L.A. ,   Samara State Medical University, Samara, Russian Federation, Filina N.Yu. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Kaladze Khatuna ,   Grigol Robakidze University, Tbilisi, Georgia, Satygo E.A. ,   I.I.Mechnikov North-West State Medical University, Saint Petersburg, Russian Federation, Stebeleva Yu.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Krasavina T.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: September 2021

In this article, we described specific features of baby skin and care for it (washing baby's face, bottom; cleaning ears, nose, and eyes; baby's bathing). We also assessed the efficacy of cream-balm ‘Tamba-PS’ (‘Adonis’ LLC, Russia) for the treatment of atopic dermatitis. ‘Tamba-PS’ contains only natural ingredients, including oil extract of native peloids from Lake Tambukan, plant extracts and essential oils, propolis, mumiyo, beeswax, honey, olive oil, sea buckthorn oil, coconut oil, and lecithin. We demonstrated its efficacy in infants and children aged 3 months to 3 years with both focal skin lesions and advanced lesions. Treatment improved children's quality of life, which was evaluated using the Dermatology Life Quality Index (DLQI) for children (from 22.8 ± 3.1 to 10.1 ± 2.0, р < 0.01); ‘socialization’ (according to the ‘KID-questionnaire,’ p ≤ 0.05) and the dynamics of clinical manifestations according to the SCORAD index (from 33.1 ± 2.9 to 14.2 ± 1.8 after therapy, p < 0.01). The unique composition of ‘Tamba-PS’ allows its daily use for problematic, irritated skin of children, as well as to protect normal skin from adverse effects, and as the external therapy for atopic dermatitis (the minimum course is 2 weeks (twice a day); the courses can be repeated if necessary). Key words: atopic dermatitis, Lake Tambukan mud, peloid therapy, skin care
Comparison of Protein Concentration in Red and White Muscles in Two Species of Bony Fish
Authors: Abd-alsahb Noor Makki , Mansour Akeil Jameil , AL-Asadi Sarmad Awad Mozan
Published: September 2021

The current study deals with estimating the protein concentration and the effect of fish weight on protein concentration values in red and white muscles in two different regions ( R1 : Anterior region lies 2 cm behind the head and R2: posterior region lies 2cm from caudal fin  (in  two types of bony fish, namely common carp (Cyprinus carpio) and Nile tilapia (Oreochromis niloticus). Samples were collected from Karmat Ali river- north of Basrah between October 2019 and February 2020. The protein was extracted using protein extraction buffer, the current study show that the average of  protein concentration in red muscles of Nile tilapia ranged between  7.74-7.4 mg / ml  and ( 6.8-8.85 mg / ml) in R1 and R2 region respectively, while it ranged between 173-334 mg / ml and 127-253 mg / ml  in R1and R2 region in white muscles, respectively. In Carp, protein concentration for red muscles was 7.19-9.10 mg / ml and  6.87-8.41 mg / ml  in R1 and R2 regions, respectively. On the other hand,  protein concentration in white muscles ranged between 98.7-250.2 mg / ml and 61.5-214.1 mg / ml  in both  R1 and R2 regions respectively. The statistical analysis results of the protein concentration in the red and white muscles in the body regions indicated that there was a significant difference(P<0.05) and non- significant difference (P>0.05) between the protein concentration in red and white muscles in the studied species ,The current study concluded that white muscles contain a higher protein concentration than red muscles and that weight gain has a significant effect on protein concentration in white muscles.
Effect of different levels and sizes of walnut seed residues on phosphorus availability and alkaline phosphatase activity in calcareous soil
Authors: Saheed Sakar Abdulqadr , Aweez Shakar Jamal , Ahmed Snowber Muhamad
Published: September 2021

A laboratory experiment has been carried out in the College of Science-University of Salahaddin to study the effect of different levels (0,5,10 and 15%) and sizes(250 and 1000µm) of walnut seeds residues and (160mg.kg-1) phosphorus fertilization on the concentration of phosphorus availability and alkaline phosphatase activity in calcareous soil during 15 and 30 days period of incubation, the experimental design in factorial complet randomize design (C.R.D) with three replications. The results indicated that the application of different levels of walnut seed residues decreases the concentration of phosphorus availability and alkaline phosphatase activity, however the results revealed that combination between levels and sizes of sieved walnut seed residues and phosphorus fertilizer significantly (p≤0.05) affected the alkaline phosphatase activity and the concentration of available phosphorus, the highest values (29.633 µgPNPg-1.hr-1and 6.442mg.kg-1) have been recorded in treatments combination received 1000µm, 15% walnut seed residues and phosphorus fertilizer, respectively.
Body mass index and shortened telomere length in middle-aged female and male RUNNING HEAD: Middle-aged and shortened telomere length
Authors: Al-Thuwaini Tahreer Mohammed
Published: September 2021

Obesity is a risk factor associated with age-related disorders that accelerate aging, and it increases the risk of metabolic diseases. Therefore, this study was conducted to investigate the association of leukocyte telomere length (LTL) with the presence of higher body weight in middle-aged females and males. The study subjects comprised 160 (80 control and 80 higher body mass index BMI groups) with ranging ages of 30-50 years included and stratified for BMI. The physio-biochemical analysis was measured using enzymatic determination. Mean telomere length was determined by using the southern blotting technique. The association analysis revealed a significant variance (P < 0.01) in biochemical parameters between higher BMI groups and control including waist, lipid profile, and the level of estradiol, testosterone, follicle-stimulating hormone, and luteinizing hormone. Mean telomere length was shorter in middle-aged males compared to the females of higher BMI groups and control groups for both age groups. LTL was shorter in the overweight and obese patients compared with the control group, and these differences in LTL obese group were shorter compared to the overweight group. In conclusion, shorter telomere length was observed in middle-aged males associated with higher body weight and lipid abnormalities. Lipid/lipoprotein abnormalities can be used as a predictor for the shortened telomere length and the reduction in adiposity indices can improvement the telomere length in both overweight and obese subjects.
Colistin as A Good Monotherapy to Restrain the Pathogenicity of Acinetobacter baumannii In vivo and In vitro
Authors: Al-Haideri Halah H. , Mohammed Nagham Saad
Published: September 2021

Acinetobacter baumannii  (A. baumannii) is a major opportunistic nosocomial pathogen, mostly resistant to several groups of antibiotics. Colistin is now used as a last-line treatment for isolates that are highly resistant. The purpose of this study is to identify the importance of LptD; which is involved in the translocation of LPS from the inner membrane to the outer membrane in compartment with LptA and LptC of A. baumannii and its indispensable role as a virulence factor, and the efficiency of colistin as a monotherapy. In the current research, two isolates of A.baumannii were used, the local isolate HHR1 isolated from urine sample and the global strain ATCC 17904, and three antibiotics (colistin, rifampicin and Fosfomycin) were used as a monotherapy and synergic therapy in vivo and ex vivo. The results demonstrated that A. baumannii HHR1 was more resistant to Antimicrobial peptides (AMPs) than the standard strains. The effect of AMPs  on A. baumannii was increased by increasing the concentration and the time of incubation, and also AMPs were shown to be lethal on A. baumannii growth spatially at high concentration (2 µg ml-1) in  monotherapy and (1.5, 2 µg ml-1) in synergic. The susceptibility of isolates towards antibiotics was variable, where colistin exerts significant growth had defect as a monotherapy and in combination with others. The results showed that the expression of lptD, lptA genes of A.baumannii HHR1 were  higher than of  the same genes in A.baumannii ATCC 17904 in the presence of 2 µg ml-1  colistin, while lptE gene of the A.baumannii ATCC 17904 showed an upregulation pattern  than in A.baumannii HHR1. Furthermore, colistin influences the adhesion ability of A. baumannii on epithelial cells (A-549 lung cancer cell) by reducing the number of cells, and thus could colistin be a good candidate for A. baunmannii treatment.
Psychometric Properties of the Persian Structured Clinical Interview for Personality Disorders of DSM-5-Personality Version (SCID-5-PD)
Authors: Gharraee Banafsheh , Shabani Amir , Masoumian Samira , Zamirinejad Somayeh , Yaghmaeezadeh Hooman , Khanjani Sajad , Ghahremani Susan
Published: September 2021

Background: The aim of this study was to investigate the psychometric properties of the Persian version of a structured clinical interview for personality disorders based on DSM-5 (R) (SCID-5-PD) in the population of patients with psychiatric disorders in Tehran.Method: The study population includes all outpatients and inpatients referred to three psychiatric centers in Tehran, including Iran Psychiatric Hospital, Rasoul Akram Hospital and Clinic of Behavioral Sciences and Mental Health (Tehran Psychiatric Institute). Inclusion criteria were age between 16 and 70 years, written Informed consent and the ability to understand and speak in Persian and no special physical problems that interfere with the interview process. Sampling in this study was done by Convenience sampling. In this study, in addition to the demographic questionnaire, the Persian version of SCID-5-PD was used. Finally, in order to evaluate the information, the methods of face and content validity and diagnostic validity, test-retest reliability and inter-rater reliability were used.Results: the diagnoses related to obsessive-compulsive personality disorder, paranoid, schizotypal, schizoid, histrionic, narcissistic, borderline and antisocial kappa were higher than 0.4 and the diagnoses related to avoidant personality disorder were dependent and in other certain disorders are below 0.4. Regarding borderline personality disorder with kappa 0.839, the highest agreement was reported between the two reports of the psychiatrist and the SCID interviewer. Also, the specificity results were mostly better than the sensitivity results, and in all diagnoses except obsessive-compulsive and paranoid personality disorder, the specificity was higher than 0.9 and in these two diagnoses, the specificity was higher than 0.85, which indicates the desired characteristic. SCID-5-PD. The sensitivity of all diagnoses except avoidant and dependent personality disorder was also reported to be higher than 0.8; But the susceptibility of avoidant and dependent personality disorder was 0.66. Also, the study of LR + / LR- ratio showed that this tool has the best diagnosis for histrionic, antisocial and schizotypal personality disorder. It is also suitable for other personality disorders except schizoid personality disorder and certain other disorders.Conclusion: According to the findings of the present study, SCID-5-PD can be used in psychiatric clinics and hospitals as a diagnostic tool. In general, this version is suitable for most diagnoses; but with regard to diagnoses of schizoid personality disorder and certain other disorders, this should be done with more caution.
PI3K/AKT/mTOR Signalling Inhibitor Chrysophanol Ameliorates Neurobehavioural and Neurochemical Defects in Propionic Acid-induced Experimental Model of Autism
Authors: Sharma Aarti , Mehan Sidharth
Published: September 2021

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social-communication deficits and repetitive behaviour. Several studies have revealed that overactivation of the PI3K/AKT/mTOR signalling pathways during brain development plays an important role in the pathogenesis of autism. The PI3K/AKT/mTOR signalling pathway overexpression produces neurological abnormalities by increasing cell death, neuroinflammation, and oxidative stress. Chrysophanol, also known as chrysophanic acid, is a natural substance derived from the plant Rheum palmatum, a well-known Chinese herbal remedy with potential pharmacological applications. The purpose of this study was to look into the neuroprotective effect of CPH on neurobehavioral, molecular, neurochemical, and gross pathological changes in ICV-PPA-induced autism-like rats, with a particular emphasis on its effect on PI3K/AKT/mTOR downregulation in the brain. Furthermore, we looked at how CPH affected the levels of myelin basic protein (MBP) in rat brain homogenate, as well as apoptotic markers such caspase-3, Bax, and Bcl-2 levels in rat brain homogenate and blood plasma samples. Rats were examined for behavioural abnormalities, like neuromuscular dysfunction using actophotometer, motor coordination by beam crossing task (BCT), depressive behaviour with forced swim test (FST), cognitive deficit, and consolidation of memory using Morris water maze (MWM) task. Prolonged oral CPH administration from day 12 to day 44 of the experimental schedule reduces autistic-like symptoms in PPA-treated rats. In addition, cellular, molecular, cell death markers, neuroinflammatory cytokines, neurotransmitter levels, and oxidative stress indicators have been examined in rat brain homogenates, blood plasma, and CSF samples. The current findings suggest that CPH also restores the altered neurochemical levels and potentially prevents autism-like gross pathological changes, including demyelination volume in the rat brain.
Cost–benefit Analysis of Human Papillomavirus Vaccine in Iran
Authors: Sargazi Nasrin , Takian Amirhossein , Daroudi Rajabali , Nahvijou Azin , Yaseri Mehdi , Motlagh Ali Ghanbari , Zendehdel Kazem
Published: September 2021

Background: Despite increasing global attention to the national human papillomavirus (HPV) immunization program, this program is controversial in Iran. Evidence indicate that HPV vaccination is not cost-effective in Iran. Using cost-effectiveness analysis for decision-making about public health interventions such as vaccination is debated, because its potential benefits may not fit this framework. Our objective was to evaluate economic effects of HPV vaccination by cost-benefit analysis (CBA). In this case, we used bivalent and quadrivalent in Iran in 2020. Methods: We performed a CBA from a societal perspective. We used two approaches of the vaccine's economic benefit: willingness to pay by discrete choice experiment; and cost of illness. Costs only included the vaccine cost. Results: The cost of two doses of bivalent and quadrivalent vaccines were US $ 29 and US $ 151, respectively (US $1 =IRR 42,000). The benefits of bivalent and quadrivalent vaccines were US $ -432, and US $ 380 per person using willingness to pay approach and they were US $ 7,375 and US $ 6,590 thorough cost-of-illness approach. The cost-benefit ratio (CBR) of bivalent and quadrivalent vaccines was -15.114 and 2.512 by willingness to pay approach, and it was 258.12 and 43.51, by cost of illness approach. Conclusions: This study confirms the benefit of both the national bivalent and quadrivalent vaccination program and provide reliable evidence for policy-makers when programming HPV vaccination.