bluuebunny/crossref_metadata_2025 huggingface dataset:
The Guinardera quarry (Sant Martí de Tous, Barcelona): A new chert exploitation location during historical times
Authors: Gómez de Soler Bruno , Soares-Remiseiro Miguel , Arteaga-Brieba Andión , Borràs Gisela , Cámara Javier , Campeny Gerard , Chacón M. Gema , Fernández-Marchena Juan Luis , Guinart Vicenç , López Gerard , Mas Bàrbara , Soto María , Suesta Alfredo , Shkarinska Kateryna , Ramírez-Pedraza Iván , Val-Peón Cristina , Vallverdú Josep
Published: January 2022

In 2014, an anthropic accumulation of chert material was discovered in La Guinardera area, at the southwest of the Sant Martí de Tous town (Barcelona, NE Iberian Peninsula). In 2018 a first archaeological intervention was carried out in two locations: La Guinardera and La Guinardera Nord. After the fieldworks, these two accumulations were interpreted as chert workshops. These workshops are in the St. Genís Formation, included within La Noguera lacustrine system and dated to the Priabonian age (upper Eocene). The St. Martí de Tous area presents shallow lacustrine conditions typical of sabkha environments, in which layers of gypsums and sandy lutites are interspersed with tabular red sandstone levels, yielding different varieties of chert.

The Guinardera chert is characterized by a fairly homogeneous matrix, presenting a fine texture, with a microcrystalline and spherulitic length-slow chalcedony matrix, and a combination of grey colours, in general of dark hues, with an opaque diaphaneity but translucent at the edges.

The archaeological assemblage from La Guinardera Nord site allows us to identify a chert workshop for the production of gunflints. The heterogeneity of the assemblage at La Guinardera site precludes assigning it to any single chrono-cultural period or function.

The technological characterization of La Guinardera Nord site reveals distinctive attributes of a gunflint workshop that can be differentiated from prehistoric workshops. The presence of square and thick preforms, oxide traces on butts and ventral faces, marked bulbs and thick platforms, together with fresh edges on flakes and blades and the near-absence of patinated materials, corroborate it.

The presence of these two deposits within the above-mentioned formation shows us a repeated landscape exploitation pattern for raw material extraction, since references chert use range from the Middle Palaeolithic (e.g., Abric Romaní) to historical times (e.g., La Guinardera Nord).
Study of Effect of Noise on Multi Input Single Output FLC and AIFLC
Authors: Annigeri Dr. Rekha
Published: January 2022

Abstract: This paper represents effect of noise on multi input and output FLC and AIFLC. Noise is a term referred as unwanted electrical signals that accompany the message signals. These unwanted signals arise from a variety of sources and can be classified as man-made or naturally. Introduction of noise/disturbance causes instability in the control system. Hence, it is very essential to study the effect of noise. Noise reduction is an important issue in any process control application. Noise contaminates the process control signals. Noise imposed on the process controller may be of entirely unknown composition, which degrades the quality of the controlling signals. The sources of noise may be external to the system or internal to the system. In usual laboratory conditions, feedback control systems do suppress noise. The present paper shows the effects of uniform white noise are studied for the speed control of BLDC motor using 3 input single output FLC and AIFLC and 2 input single output FLC and AIFLC. Keywords: Fuzzy logic Tool kit, Labview,
Effect of Sosiho-tang on a Thioacetamide-induced Liver Fibrosis Mouse Model
Authors: Lee Se Hui , Oh Min Hyuck , Shin Mi-Rae , Lee Ji Hye , Roh Seong-Soo
Published: January 2022

Objectives: The aim of the current study was to investigate the effect of Sosiho-tang on thioacetamide (TAA)-induced liver fibrosis in mice and to elucidate its underlying mechanisms.Methods: The mice were divided into 4 groups: Normal mice (Normal), TAA-induced control mice (Control), TAA-induced and silymarin-treated (50 mg/kg) mice (Silymarin), and TAA-induced and Sosiho-tang treated (200 mg/kg) mice (SSHT). Liver fibrosis was induced via intraperitoneal injection of TAA three times a week for 8 weeks. Silymarin and Sosiho-tang were concomitantly administered for 8 weeks. Serum and liver tissues were then collected and the anti-oxidant and inflammatory protein levels in the liver tissues were evaluated using western blotting.Results: SSHT administration significantly reduced the levels of AST, ALT, ammonia, and MPO in the serum. SSHT also significantly down-regulated liver NADPH oxidase and regulated the Nrf2/Keap1 signaling pathway. SSHT treatment downregulated the liver NF-κB levels and suppressed inflammatory cytokines. SSHT treatment also decreased bile acid-related factors, such as CYP7A1 and NTCP, and fibrosis-related factors, such as α-SMA and Collagen Ⅰ.Conclusions: Taken together, these data suggest that SSHT administration suppressed the progression of liver fibrosis by activating the Nrf2/Keap1 pathway and inhibiting NF-κB.
Problemas de la Generación, Disposición y Tratamiento de los Residuos Sólidos en el Municipio de Quibdó, Colombia
Authors: Ortega-Ramírez Angie Tatiana , Marín-Maldonado Diego Fernando , Castro Nelly Elmira
Published: January 2022

La gestión integral de los residuos sólidos constituye un desafío enfocado al cuidado y preservación del medio ambiente; teniendo en cuenta que la mayoría de la población no realiza una separación en la fuente de manera adecuada. En este sentido, el municipio de Quibdó no es ajeno a dicha situación, pues además de la falta de cultura ciudadana reflejada en una inadecuada separación en la fuente, se suma la deficiencia en materia de disposición final de residuos, llevada a cabo en el botadero a cielo abierto “Marmolejo”, ocasionando importantes impactos negativos sobre el medio ambiente y la salud pública. El presente artículo recopila información sobre las principales fuentes de generación, el manejo y la disposición final de los residuos sólidos llevada a cabo actualmente en Quibdó; enfocándose en identificar la problemática actual y los principales retos que tiene el municipio en materia de manejo de residuos, así como también los diferentes procesos y programas que se desarrollan encaminados a una adecuada gestión y/o aprovechamiento de los desechos producidos, lo que permitiría considerar la identificación e implementación de alternativas para la el desarrollo de procesos de economía circular y por ende la generación de empresas sostenibles en la región.
Dynamics and recognition of homeodomain containing protein-DNA complex of IRX4
Authors: Malik Adil , Gandhi Neha S. , Batra Jyotsna
Published: January 2022

Iroquois Homeobox 4 (IRX4) belongs to a family of homeobox TFs having
roles in embryogenesis, cell specification and organ development.
Recently, Large scale Genome-Wide Association studies and epigenetic
studies have highlighted the role of IRX4 and its associated
variants in prostate cancer. No studies have investigated and
characterized the structural aspect of the IRX4 homeodomain and its
potential to bind to DNA. The current study uses sequence analysis,
homology modelling and molecular dynamics simulations to explore IRX4
homeodomain-DNA recognition mechanisms and the role of somatic mutations
affecting these interactions. Using publicly available databases, gene
expression of IRX4 was found in different tissues, including
prostate, heart, skin, vagina, and the protein expression was found in
cancer cell lines (HCT166, HEK293), B cells, ascitic fluid and brain.
Sequence conservation of the homeodomain shed light on the importance of
N- and C-terminal residues involved in DNA binding. The specificity of
IRX4 homodimer bound to consensus human DNA sequence was confirmed by
molecular dynamics simulations, representing the role of conserved amino
acids including R145, A194, N195, S190, R198 and R199 in binding to DNA.
Additional N-terminal residues like T144 and G143 were also found to
have specific interactions highlighting the importance of N-terminus of
the homeodomain in DNA recognition. Additionally, the effects of somatic
mutations, including the conserved Arginine (R145, R198 and R199)
residues on DNA binding elucidated the importance of these residues in
stabilizing the protein-DNA complex. Secondary structure and hydrogen
bonding analysis showed the roles of specific residues (R145, T191,
A194, N195, R198 and R199) in maintaining the homogeneity of the
structure and its interaction with DNA. The differences in relative
binding free energies of all the mutants shed light on the structural
modularity of this protein and the dynamics behind protein-DNA
interaction. We also have predicted that the C-terminal sequence of the
IRX4 homeodomain could act as a potential cell-penetrating peptide,
emphasizing the role these small peptides could play in targeting
homeobox TFs.
Optimization of fast three-electrode spark gaps isolated with a SF6 and he mixture
Authors: Nedic Teodora , Lazarevic Djordje , Stankovic Koviljka , Kartalovic Nenad
Published: January 2022

This paper considered the possibility of reducing the dissipation of the
trigger time of the three-electrode spark gaps with a separated triggered
electrode. The work is of a theoretical, numerical and of experimental
nature. The experiments were performed on a spark gap model under
well-controlled laboratory conditions. It was determined that the results
obtained with the model can be applied to the spark gap prototype. Unlike
the previous research in this area, the computer-designed spark gap that was
used can be triggered with one mechanism only. Also, as opposed to the
previous study, a mixture of SF6 and He gases and the third electrode with a
double ionization effect were used. The obtained results showed the optimal
combination of the construction solution, insulation gas, triggered
impulse, and the triggered electrode's shape, reduce the stochastic
dissipation of a random variable far in the sub-microsecond field. This
result is of great significance for the parallel triggering of current and
voltage generators to obtain the best superposition signals.
The possibility for gamma and UV radiation detection based on electrical breakdown time delay measurement in krypton and xenon filled diodes
Authors: Pejovic Milic , Zivanovic Emilija , Belic Cedomir
Published: January 2022

The paper presents results of electrical breakdown time delay mean value t?d
as a function of relaxation time ? (memory curve) for krypton and
xenon-filled diodes at 270 Pa pressure. Memory curves were obtained for the
cases without radiation as well as in the presence of gamma and UV
radiation. It was shown that significant influence of UV radiation to t?d can
be observed for ? ? 100 ms, as well as gamma radiation for ? ? 103 ms.
Laue's distribution was also investigated for electrical breakdown time
delay data sets td, obtained for ? ? 150 ms, without radiation as well as in
the presence of gamma and UV radiation. It was shown that for all these data
sets Laue's distribution stands, except for the case when krypton-filled
tube was subjected to UV radiation. On the basis of the obtained results,
the throughout analysis was performed with the aim to investigate
possible application of these diodes as sensors of gamma and UV
radiation.
Radiation safety aspects of 90Y bremsstrahlung radiation produced from radiation shielding apparatus using the Monte Carlo simulation
Authors: Jumpee Chayanit , Onnomdee Chanakarn , Charoenphun Putthiporn , Phruksarojanakun Phiphat , Chuamsaamarkkee Krisanat
Published: January 2022

Selective internal radiation therapy using an 90Y labelled microsphere is
increasingly used to treat hepatocellular carcinoma. Based on its
properties, 90Y can produce bremsstrahlung radiation which is essential
for post-treatment localisation and dosimetry. However, bremsstrahlung
radiation could lead to an increase of radiation exposure of radiation
workers. The aim of this work was to determine the 90Y
bremsstrahlung radiation produced from the polymethyl methacrylate
radiation shielding apparatus using the Monte Carlo simulation. A
scintillation detector with a 137Cs standard source was used to validate the
Monte Carlo simulation. After validation, the 90Y bremsstrahlung photons
spectrum produced from the radiation shielding apparatus was simulated.
The radiation equivalent dose rates to the head, neck, body, lower
extremities at a distance of 30 centimeters, and finger (contact with the
knob) were estimated to be 4.9 ? 0.6, 6.2 ? 0.1, 18.9 ? 0.4, 13.1 ? 0.6, and
3900 ? 50 ?Svh?1, respectively. The corresponding annual doses exceeded
the limit when radiation workers performed 2631, 1563, 769, and 515 cases
per year with contact the knob 3, 5, 10, and 15 minutes per case,
respectively. The simulation result showed that radiation exposure of
radiation workers and the number of selective internal radiation therapy
procedures performed should be considered.
Dose assessment with MCNP5/X code for boron neutron capture therapy of pancreas cancer
Authors: Krstic Dragana , Nikezic Dragoslav , Zivkovic Milena , Jeremic Marija
Published: January 2022

Boron neutron capture therapy is based on neutron capture by 10B and creation
of high energy alpha particle and recoiled 7Li ion which have ranges
comparable to cell dimensions. The MCNP5/X code is applied for calculation
of the absorbed doses as well as dose distribution by depth in pancreas
cancer and the organs of the analytical and voxelized Oak Ridge National
Laboratory phantom, which represents the human body. The depth dose
distributions for thermal, epithermal neutrons, and neutron spectrum, show
that the absorbed doses are the largest exactly in the cancer, in all cases.
It is found by this simulation that the epithermal neutrons are the
optimal choice for BNC therapy. They deliver a similar dose to cancer as the
thermal neutrons but, spare the healthy tissue more than the thermal ones.
Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes
Authors: Koska Juraj , Gerstein Hertzel C. , Beisswenger Paul J. , Reaven Peter D.
Published: January 2022

OBJECTIVE

To evaluate the association of a multicomponent advanced glycation end product (AGE) panel with decline in kidney function and its utility in predicting renal function loss (RFL) when added to routine clinical measures in type 2 diabetes.

RESEARCH DESIGN AND METHODS

Carboxymethyl and carboxyethyl lysine and methylglyoxal, 3-deoxyglucosone, and glyoxal hydroimidazolones were measured in baseline serum and plasma samples, respectively, from Action to Control Cardiovascular Risk in Diabetes (ACCORD) (n = 1,150) and Veterans Affairs Diabetes Trial (VADT) (n = 447) participants. A composite AGE score was calculated from individual AGE z scores. The primary outcome was a sustained 30% decline in estimated glomerular filtration rate (eGFR) (30% RFL in both cohorts). Secondary outcomes (in ACCORD) were 40% RFL, macroalbuminuria, and high-risk chronic kidney disease (hrCKD).

RESULTS

After adjustment for baseline and follow-up HbA1c and other risk factors in ACCORD, the AGE score was associated with reduction in eGFR (β-estimate −0.66 mL/min ⋅ 1.73 m2 per year; P = 0.001), 30% RFL (hazard ratio 1.42 [95% CI 1.13–1.78]; P = 0.003), 40% RFL (1.40 [1.13–1.74]; P = 0.003), macroalbuminuria (1.53 [1.13–2.06]; P = 0.006), and hrCKD (1.88 [1.37–2.57]; P < 0.0001). AGE score improved net reclassification (NRI) and relative integrated discrimination (IDI) for 30% RFL (NRI 23%; P = 0.02) (relative IDI 7%; P = 0.009). In VADT, the AGE score calculated by the ACCORD-derived coefficients was associated with 30% RFL (1.37 [1.03–1.82); P = 0.03) and improved NRI (24%; P = 0.03) but not IDI (P = 0.18).

CONCLUSIONS

These data provide further support for a causal role of AGEs in diabetic nephropathy independently of glycemic control and suggest utility of the composite AGE panel in predicting long-term decline in renal function.
2022 National Standards for Diabetes Self-Management Education and Support
Authors: Davis Jody , Fischl Amy Hess , Beck Joni , Browning Lillian , Carter Amy , Condon Jo Ellen , Dennison Michelle , Francis Terri , Hughes Peter J. , Jaime Stephen , Lau Ka Hei Karen , McArthur Teresa , McAvoy Karen , Magee Michelle , Newby Olivia , Ponder Stephen W. , Quraishi Uzma , Rawlings Kelly , Socke Julia , Stancil Michelle , Uelmen Sacha , Villalobos Suzanne
Published: January 2022

By the most recent estimates, 34.2 million
people in the U.S. have diabetes.1 At the same time, 88 million people are at increased risk for developing
type 2 diabetes. The U.S. also sees an increasing prevalence of both type 1 and
type 2 diabetes in children and adolescents.2 Thus,
more than 122 million Americans are at risk of developing devastating
complications associated with chronic hyperglycemia.1 Diabetes self-management education and support (DSMES) is a critical
element of care for all people with diabetes (PWD). “The purpose of DSMES is to
give PWD the knowledge, skills, and confidence to accept responsibility for
their self-management. This includes collaborating with their healthcare team,
making informed decisions, solving problems, developing personal goals and
action plans, and coping with emotions and life stresses.”3 DSMES interventions include activities that support PWD to implement
and sustain the self-management behaviors and strategies to improve diabetes and
related cardiometabolic conditions and quality of life on an ongoing basis. Despite
progress in diabetes treatment modalities, glycemic and cardiometabolic
outcomes continue to decline in the U.S.4 Now,
more than ever, the provision of DSMES is a vital component of the full
treatment for diabetes.
ANÓNIMO, «Homilía de Wessobrunn»
Authors: Ayerbe Linares Miguel
Published: January 2022

Resumen
SISTEM INVENTORI DAN PENGGAJIAN TOKO METRO ELEKTRONIK BERBASIS WEB DAN DESKTOP
Authors: Iskandar Davin
Published: January 2022

Metro Elektronik is a shop that selling various kinds of electronic goods such as refrigerator, air conditioner, television, etc. The current system that run in metro elektronik now has many flaws and reduce the overall performance of store mainly because of data integrity and inconsistency. Using php and java today I built a application that can help Metro Elektronik solve it’s problem.
PERANCANGAN APLIKASI PENJUALAN PADA TOKO BUAH MINIMARKET ESI BERBASIS DESKTOP DAN WEBSITE
Authors: Jacky Jacky
Published: January 2022

"Perancangan Aplikasi Penjualan Pada Toko Buah Minimarket ESI berbasis Desktop dan Website merupakan sebuah aplikasi e-commerce yang berbasis desktop dan website. Basis desktop digunakan untuk penginputan data, data buah dan kasir, hanya digunakan oleh admin. Basis website memiliki fitur untuk pemesanan buah online, input buah dan laporan penjualan. Pengujian dilakukan dengan tujuan agar didapatkan hasil dari permrosesan yang dilakukan oleh aplikasi, setelah melakukan pengujian terhadap integrase data antara basis desktop dan basis website, maka dapat disimpulkan bahwa kedua data sudah terintegrasi dan terhubung dengan baik. Berdasarkan hasil kuisioner dapat disimpulkan bahwa pemilik maupun pengguna tertarik untuk menggunakan aplikasi tersebut.
Effect of Organic and Non Organic Acids on the Blend PES/PS/PVDF Polymer Membranes Efficiency for Microbial Fuel Cell
Authors: Al-Ta,ay Zainab Ali , Allami Shrok , Shihab Mehdi Salih
Published: January 2022

In this work proton exchange membranes were prepared by a modified microwave casting solution technique, using the polymers blend (polyethersulfone (PES), polystyrene (PS), polyvinylidenefluride (PVDF)). Modified casting method was used to overcome the poor compatibility between hydrophilic, (PES, PS) and hydrophobic PVDF, by cooling the substrate during the film casting process to (4.5-5.5oC). Membranes were chemically modified by three reaction types to study the differences between their effects on the required properties for microbial fuel cell application. These methods use blend organic sulfonic acid precasting process and sulfonation by sulfuric acid post-casting process (APS), blending organic sulfonic acid precasting process (AS) and sulfonation by sulfuric acid post-casting process (AP). The presence of organic sulfonic acid and the sulfonation were confirmed via FTIR spectra for the membranes. The membranes were characterized by proton conductivity, ion exchange capacity (IEC), [-SO3H] value, and water uptake. MFC is characterized by electrochemical polarization tests and power densities obtained from it were used to evaluate the efficiency of the membrane in the cell.
Analytical Approaches for Porous Media Geothermal Power Calculations
Authors: Birdsell Daniel T. , Adams Benjamin M. , Ogland-Hand Jonathan D. , Bielicki Jeffrey M. , Fleming Mark R. , Saar Martin O.
Published: January 2022

Geothermal electricity generation may play a role in reducing greenhouse gas emissions and addressing climate change in a cost-effective manner. Reservoir equations for pressure and temperature must be coupled to a power cycle model to calculate electricity generation from a geothermal power plant. This work focuses on sedimentary basin geothermal power production, which relies on flow through porous and permeable aquifers in sedimentary basins. Previous work has used numerical reservoir simulators, but we introduce analytical reservoir solutions for reservoir impedance, wellbore heat loss, and reservoir heat depletion in this work. The reservoir impedance and wellbore heat loss solutions are combined with a power cycle model to calculate electricity generation. The reservoir heat depletion solution provides insight into the reservoir lifetime because electricity generation decreases with reservoir temperature. We compare the analytical and numerical approaches and discuss their implications for geothermal electricity generation from sedimentary basins. Both approaches have merits, and the comparison herein can guide those who want to understand geothermal electricity production.
HADOKEN: An Open-Source Software Package for Predicting Electron Confinement Effects in Various Nanowire Geometries and Configurations
Authors: Wong Bryan , Chevalier Cameron
Published: January 2022

We present an open-source software package, HADOKEN (High-level Algorithms to Design, Optimize, and Keep Electrons in Nanowires), for predicting electron confinement/localization effects in nanowires with various geometries, arbitrary number of concentric shell layers, doping densities, and external boundary conditions. The HADOKEN code is written in the MATLAB programming environments to aid in its readability and general accessibility to both users and practitioners. We provide several examples and outputs on a variety of different nanowire geometries, boundary conditions, and doping densities to demonstrate the capabilities of the HADOKEN software package. As such, the use of this predictive and versatile tool by both experimentalists and theorists could lead to further advances in both understanding and tailoring electron confinement effects in these nanosystems.
Identification of HDAC10 Inhibitors that Modulate Autophagy-Related Proteins in Transformed Cells
Authors: Zeyen Patrik , Zeyn Yanira , Herp Daniel , Mahmoudi Fereshteh , Yesiloglu Talha , Erdmann Frank , Schmidt Matthias , Robaa Dina , Romier Christophe , Ridinger Johannes , Christianson David , Oehme Ina , Jung Manfred , Kraemer Holger , Sippl Wolfgang
Published: January 2022

Histone deacetylases (HDACs) are a family of 18 epigenetic modifiers that fall into 4 classes. Histone deacetylase inhibitors (HDACi) are valid tools to assess HDAC functions. HDAC6 and HDAC10 belong to the class IIb subgroup of the HDAC family. The targets and biological functions of HDAC10 are ill-defined. This lack of knowledge is due to a lack of specific and potent HDAC10 inhibitors with cellular activity. Here, we have synthesized and characterized piperidine-4-acrylhydroxamates as potent and highly selective inhibitors of HDAC10. This was achieved by addressing the acidic gatekeeper residue Glu274 of HDAC10 with a basic piperidine moiety that is mimicking the interaction of the oligoamine substrate of HDAC10. Promising candidates were selected based on their specificity by in vitro profiling using recombinant HDACs. The most promising HDAC10 inhibitors 13b and 10c were tested for specificity in acute myeloid leukemia (AML) cells with the FLT3-ITD oncogene. By immunoblot experiments we assessed the hyperacetylation of histones and tubulin-α, which are class I and HDAC6 substrates, respectively. As validated test for HDAC10 inhibition we used flow cytometry assessing autolysosome formation in neuroblastoma and AML cells. We demonstrate that this is not a consequence of apoptosis and 13b and 10c are not toxic for normal human kidney cells. These data unravel that 13b and 10c are micromolar inhibitors of HDAC10 with high specificity. Thus, our new HDAC10 inhibitors are tools to identify the downstream targets and functions of HDAC10 in cells.
Efekt zarażania w Europie Środkowo-Wschodniej w czasie kryzysu pandemicznego. Zastosowanie metody regresji kwantylowej
Authors: Grabowski Wojciech
Published: January 2022

Przedmiot badań: W niniejszym artykule badane są powiązania między rynkami giełdowymi stosującymi strategię bezpośredniego celu inflacyjnego największych gospodarek Europy Środ­kowo-Wschodniej w latach 2020–2021.

Cel badawczy: Badanie empiryczne ma na celu identyfikację wpływu pandemii koronawirusa oraz niepewności na rynkach giełdowych i walutowych na skalę zarażania między rynkami kapi­tałowymi w Europie Środkowo-Wschodniej.

Metoda badawcza: Wykorzystywana jest metoda regresji kwantylowej.

Wyniki: Rezultaty wskazują, że zarówno globalna, jak i krajowa niepewność na rynku giełdo­wym wpływała na transmisję szoków pozytywnych i negatywnych. Zaobserwowane zostały rów­nież powiązania między niepewnością na rynkach walutowych Polski, Czech i Węgier a inten­sywnością transmisji szoków między giełdami tych krajów. Przebieg pandemii koronawirusa miał silny wpływ na zachowania inwestorów i wzmacniał transmisję szoków.
Uwagi o charakterze prawnym konsorcjum
Authors: Byczko Szymon
Published: January 2022

Przedmiot badań: Przedmiotem pracy jest próba określenia charakteru prawnego umowy kon­sorcjum jako formy współpracy przedsiębiorców. Jest to zagadnienie o tyle istotne, że ta for­ma współdziałania, dość często spotykana przy realizacji dużych zadań gospodarczych, nie jest uregulowana prawnie. Brak jest także obszerniejszych wypowiedzi doktryny co do konsorcjum, a zwłaszcza prób określenia charakteru prawnego tej umowy.

Cel badawczy: Ustalenie, czy konsorcjum może być uznane za samodzielną umowę o współpra­cy gospodarczej, czy też jest ono jedynie podtypem spółki cywilnej. Ustalenie samodzielności konstrukcji konsorcjum wymagało z kolei zbadania charakteru prawnego tej umowy.

Metoda badawcza: W badaniach zagadnienia oparto się na analizie dość skąpego piśmiennictwa dotyczącego konsorcjum oraz – znacznie bogatszego – orzecznictwa Sądu Najwyższego. Orzecz­nictwo Sądu Najwyższego dotyczące konsorcjum jest utrwalone i konsekwentne, uwzględniając specyfikę tej konstrukcji prawnej i praktyczne potrzeby podmiotów, które zdecydowały się na wybór takiej właśnie formy prawnej. W pracy konieczne było także odwołanie się do poglądów doktryny dotyczących charakteru prawnego spółek, tak by wskazać na samodzielność i odrębność konstrukcji prawnej konsorcjum.

Wnioski: analiza wykazała, że konsorcjum należy uznać za samodzielną umowę nienazwaną, dość wyraźnie odróżniającą się od spółki cywilnej oraz spółek prawa handlowego. Umowa ta re­alizuje pewne powtarzalne potrzeby ekonomiczne przedsiębiorców, odmienne jednak niż w przy­padku spółek. Konsorcjum posiada w związku z tym własne cechy charakterystyczne, odmienne od spółki cywilnej i spółek prawa handlowego. W przypadku konsorcjum można wskazać na specyficzne, inne niż w spółkach zasady prowadzenia spraw i reprezentacji, z charakterystycz­ną konstrukcją lidera konsorcjum będącego pełnomocnikiem konsorcjantów. Stosunkowo krótka praktyka funkcjonowania konsorcjum w obrocie gospodarczym nie pozwala jednak na wskazanie utrwalonych cech, które pozwoliłyby ustawodawcy na wprowadzenie umowy konsorcjum do ka­talogu umów nazwanych.
Kosmopolityczny monizm versus kosmopolityczny pluralizm: cynicyzm i stoicyzm – dwa filary moralnego kosmopolityzmu
Authors: Chmieliński Maciej
Published: January 2022

Przedmiot badań. Na przełomie XX i XXI w. kosmopolityzm stał się przedmiotem intensyw­nych badań. Jednym z kluczowych zagadnień będących przedmiotem zainteresowania jest pro­blematyka relacji pomiędzy narodową a kosmopolityczną tożsamością.

Cel badawczy. Celem prowadzonego badania jest porównanie dwóch modeli kosmopolityzmu, dla których relacja ta stanowi centralny punkt odniesienia. Za najbardziej charakterystyczne i jed­nocześnie najlepiej ilustrujące tę kwestię autor uznaje koncepcje moralnego kosmopolityzmu re­prezentowane z jednej strony przez greckich cyników, a z drugiej przez stoików.

Metoda badawcza. Korzystając z metody historyczno-porównawczej i krytycznej, artykuł przedstawia dwie starożytne odpowiedzi na to kluczowe pytanie. Koncepcja cyników zawiera monistyczny, podczas gdy koncepcja stoików pluralistyczny model relacji między tożsamo­ścią narodową i kosmopolityczną. Zgodnie z cynickim podejściem monistycznym lojalność wobec uniwersalnych, kosmopolitycznych „praw cnoty” ma zawsze pierwszeństwo przed lojalnością wobec lokalnej lub narodowej wspólnoty, podczas gdy oparta na idei oikeiosis pluralistyczna koncepcja stoicka daje pierwszeństwo raczej tożsamości lokalnej i narodowej niż kosmopolitycznej.

Wyniki. Porównanie tych dwóch hellenistycznych koncepcji prowadzi do wniosku, że nacecho­wana radykalnym etycznym naturalizmem monistyczna postawa cynicka, choć psychologicz­nie mniej wiarygodna niż stoicka, jest moralnie spójna i nie prowadzi cynika do etyczno-psy­chologicznego rozdarcia. Natomiast pluralistyczna postawa stoicka, mimo iż zdecydowanie bardziej wysublimowana i psychologicznie znacznie bardziej wiarygodna, może wprowadzać element wewnętrznego konfliktu pomiędzy lojalnością wobec państwa i lojalnością wobec „praw cnoty” rządzących wspólnotą kosmopolityczną. Podkreślając za cynikami wierność wobec uniwersalnych praw cnoty, stoicy pragną bowiem jednocześnie pozostać lojalni wobec własnego państwa.
Kilka uwag w kwestii sposobu zaspokojenia wierzyciela pauliańskiego w postępowaniu upadłościowym
Authors: Cieślak Sławomir
Published: January 2022

Przedmiot badań: W prawie upadłościowym brakuje szczegółowej regulacji sposobu zaspo­kojenia wierzyciela pauliańskiego z majątku osoby trzeciej, w razie ogłoszenia jej upadłości. Wywołuje to kontrowersje w doktrynie prawa upadłościowego. Konsekwencją tego niedostatku regulacji ustawowej i braku zgodności w teorii prawa jest niepewność co do pozycji prawnej tego wierzyciela w praktyce postępowania upadłościowego.

Cel badawczy: Celem artykułu jest ustalenie możliwości przyjęcia de lege lata wyniku wykładni przepisów prawa upadłościowego, kodeksu postępowania cywilnego oraz kodeksu cywilnego, który byłby zgodny założeniami aksjologicznymi prawa postępowania upadłościowego oraz in­stytucji skargi pauliańskiej. W przypadku braku takiej możliwości dalszym celem opracowania jest sformułowanie postulatu de lege ferenda pod adresem ustawodawcy, u którego podłoża leżą wspomniane założenia aksjologiczne.

Metoda badawcza: W artykule posłużono się metodą logiczno-językowej analizy materiału nor­matywnego, którą uzupełniono w niezbędnym zakresie o metodę historycznoporównawczą.

Wnioski: W sytuacji sprzeczności wartości chronionych za pomocą materialnoprawnej instytucji skargi pauliańskiej oraz leżących u podstaw postępowania upadłościowego aksjologicznie uza­sadnione jest założenie, według którego syndyk masy upadłości powinien zaspokajać wierzyciela pauliańskiego z przedmiotu, który wszedł do majątku upadłego na podstawie ubezskutecznionej czynności z pierwszeństwem przed wierzycielami upadłościowymi. Bez zmiany ustawodawczej przyjęcie wyniku wykładni przepisów Kodeksu postępowania cywilnego i Prawa upadłościo­wego, który odpowiadałby tej ocenie aksjologicznej, nie wydaje się możliwe do uzasadnienia. De lege lata wierzyciel pauliański powinien więc uczestniczyć w odrębnym podziale sumy uzy­skanej ze zbycia przedmiotu objętego wyrokiem pauliańskim. Mniej korzystne dla tego wierzy­ciela rozwiązanie ingerowałoby nadmiernie w treść prawa wierzyciela pauliańskiego określoną w art. 532 KC, przez co dochodziłoby do wypaczenia jego istoty uregulowanej w prawie material­nym. De lege lata zapewnienie temu wierzycielowi tzw. prawa odrębności trzeba więc uznać za minimalny poziom udzielanej mu w postępowaniu upadłościowym ochrony prawnej.
Електронний бізнес: переваги та ризики в період цифрової трансформації
Authors: Мельник Тетяна Юріївна , Ткачук В’ячеслав Олександрович , Богоявленська Юлія В’ячеславівна
Published: January 2022

У статті обґрунтовано доцільність створення, ведення та розвитку електронного бізнесу як актуальної бізнес-моделі в період цифрової трансформації. Авторами пропонується підхід до визначення електронного бізнесу як різновиду економічної діяльності, коли для успішної реалізації бізнес-процесів активно використовуються інформаційно-комунікаційні технології та мережі.

Існують різні базові можливості для старту електронного бізнесу. У загальному вигляді ключові напрями ведення електронного бізнесу передбачають початкове створення підприємства, яке надає послуги виключно за допомогою використання інформаційно-комунікаційних технологій та мереж, доповнення традиційних послуг електронними вже діючим підприємством (з подальшим виділенням такого виду діяльності в окремий напрям бізнесу) та поступовий перехід підприємства до ведення електронного бізнесу. До безумовних переваг ведення електронного бізнесу з використанням мережевих технологій у господарській діяльності підприємств варто зарахувати: прискорення обслуговування клієнтів, усунення обмежень щодо розташування торгових площ, магазинів, офісів та доступність для клієнтів, підтримання бізнесу в актуальному стані й орієнтування на удосконалення бізнес-процесів.

За результатами проведеного дослідження було ідентифіковано ряд ризиків, пов’язаних із веденням електронного бізнесу, основними з яких є: ризики мережевої безпеки, ризики провалів у маркетингу, ризики прихованих витрат (або витрат на обслуговування і модернізацію), бізнес-ризики (ділові ризики), ризики шахрайських дій, наприклад, з викраденими банківськими картками та ін. В цілому, розуміння ризиків електронного бізнесу необхідне для визначення підходу підприємства до управління цими ризиками, зокрема адекватності системи внутрішнього контролю. Така система може містити інфраструктуру захищеності та пов’язані із цим заходи контролю. Неврахування фактора ризику може призвести до зниження загального очікуваного результату з різними наслідками. Серед таких наслідків можуть бути: порушення життєздатності бізнесу, втрата конкурентних переваг, погіршення ділового іміджу та фінансової стабільності, зменшення сукупної економічної вигоди, додаткових витрат фінансового та нефінансового характеру тощо.
Online Ideological and Political Education in Colleges and Universities Under the Weibo Network Environment
Authors: He Jianping , Jiang Darui
Published: January 2022

In recent years, the in-depth development of quality education has brought opportunities for the innovation and reform of ideological and political education in colleges and universities in China. Online ideological and political education, as a modern embodiment of ideological and political education, is planned and carried out purposefully under the Weibo network environment, which is more conducive to breaking the distance between time and space and presenting high-quality educational content to students. In view of this, this article will focus on the development of online ideological and political education under the Weibo network environment, consider the existing problems, and propose specific countermeasures to improve the level of online ideological and political education in colleges and universities.
Sera Level and Polymorphism of Interleukin-33 Gene in Iraqi Females Patients with Breast Cancer
Authors: Almohaidi Asmaa M. Salih , Al-Abassi Hazima Mossa , Abdulkareem Zainab Jalil , Abdulkareem Zainab Jalil
Published: January 2022

Interleukin-33 [IL-33] is a specific ligand for the ST2 receptor, and a member of theIL-1 family. It is a dual-function protein that acts both as an extracellular alarmin cytokine,and an as an intracellular nuclear factor participates in maintaining barrier function byregulating gene expression of IL-33 modulating tumor growth and anti-tumor immunity incancer patients. The present study aimed to investigate the role of IL-33 serum level and genepolymorphism in Iraqi women with breast cancer. Materials and methods: Blood sampleswere collected from 66 Iraqi patient women diagnosed with breast cancer, which were dividedinto two groups: pre-treatment [PT] and under treatment with chemotherapy [UTC] patients inaddition to 34 apparently healthy women who were matched with patients as a control.ELISA technique was used to determine the IL-33 serum level. The PCR-RFLP techniquewas performed to determine IL-33 gene polymorphisms at single nucleotide polymorphismSNP [rs1929992]. Results: IL-33 serum level recorded lower significant in PT [182.22 ±29.86pg/ml] and UTC [129.87 ± 45.11pg/ml] patients compared with control [258.08 ± 39.54 pg/ml] under [p<0.05]. In a polymorphism study on IL-33 SNP [rs1929992] showed AG genotype recorded the high frequency in control than in patients [76.47, 58.46] compared to other genotypes AA, GG with no significant difference according to fisher’s exact probability. In conclusion: IL-33 serum level decreased after performing surgery on breast cancer patients. There was no association between breast cancer development and IL-33 SNP [rs1929992]. The heterozygous genotype AG was a common genotype in the Iraqi population. Allele G had an environmental fraction, while allele A had preventive fraction, which related to increasing the level of IL-33 with both genotypes AA, AG in the healthy control group, in contrast with GG genotype which showed the highest level in the patients’ group.
Foliar Spraying Alphatocopherol Enhances Salinity Stress Tolerance in Wheat Plant Triticum Aestivum L.
Authors: AL-Kazzaz Amel Ghanim Muhmood , AL-Kareemawi Inas Hasseb Khamees
Published: January 2022

Alphatocopherol is a vitamin and antioxidant compound that plays a crucial role in amelioration of biotic and abiotic stresses and protects plants from stress â€“ induced cellular  oxidation .The experiment was carried out in a green garden of the Department of  Biology, College of Education for Pure Sciences Ibn-AL-Haitham ,University of Baghdad during 2018 â€“ 2019 to evaluate the potential effects of foliar application with (0 ,50 ,100 ,150 ,200 mg.L-1) alphatocopherol on growth, yield components and the activity of antioxidant system of wheat plant under sodium chloride stress(0 ,75 , 150 ,225mM.L-1) .Results indicated that sodium chloride caused reduction in shoot dry weight and some yield components (biological yield , no. spikelet .spike-1 and 1000 grain weight)and a significant increase in the endogenous proline acid and alphatocopherol concentration and raised catalase activity. Foliar spray of alphatocopherol improved salt stress tolerance in wheat plant by increasing all the parameters.
Comparison of the Adaptation to Pregnancy in Women Who Received Infertility Treatment and Those Who Didn't
Authors: AKSU Hazal , GÜLEÇ ŞATIR Duygu
Published: January 2022

Abstract

Purpose: It was aimed to compare the adaptation to pregnancy in women who received infertility treatment and those who didn't.

Methods: A total of 174 pregnant women were included in the study, 51 in the group that received infertility treatment and 123 in the group that did not. The data were collected with the Personal Information Form including the descriptive characteristics and the Prenatal Self-Evaluation Questionnaire (PSEQ).

Results: The mean age of the pregnant women who received infertility treatment was 33.73±5.79 years, while it was 28.89±4.12 years for those who didn't. Although the mean total score of PSEQ was lower in pregnant women receiving infertility treatment, the difference was not found to be statistically significant. In the group that became pregnant with the infertility treatment, the subdimension score of "thoughts about the well-being of self and baby" was found to be higher, while the scores of subdimensions "acceptance of pregnancy", "readiness for labour" and "control in labour" were lower.

Conclusion: In the study, the adaptation to the pregnancy of both groups was found to be similar. On the other hand, pregnant women who received infertility treatment were found to have lower adaptation to the thoughts about the wellbeing of self and baby sub-dimension, and higher adaptation to the identification with the role of motherhood, preparation for labour and control in labour subdimensions.
KORELASI GAYA KEPEMIMPINAN KEPALA SEKOLAH DENGAN MOTIVASI KERJA GURU
Authors: Harun Al Rosid Moh. , Mukarromah Mukhfidatul
Published: January 2022

This study ain to determine the correlation of principal’s leadership style with work motivation of SMK Darussalam Teaschers in Blokagung Tegalsari Banyuwangi 2018/2019 Academic Year. This research was in the from of a quantitative descriptive study, with a population of all members of the teaher council and secondary data. And use the validity test to obtain relevant and accurate data. The data collection techniques in this study used a questionnaire, observation and documentation. By using data analysis techniques, prodect moment. And the last hypothesis testing to test the truth of a statement statistically and draw conclusions. Based on the discussion of the theory and the results of the analysis, discussion and interpretation results as well as some data from the field, the researcher can conclude the following: Based on the results of the questionnaire on variable X dan Y there is a significant correlation between the leadership style of the headmaster and the work motivation of teachers in SMK Darussalam Blokagung Tegalsari Banyuwangi in the 2018/2019 academic year of 0.667. this means that there is a strong relationship.
Thực trạng khai thác thủy sản của Việt Nam giai đoạn 2018-2020
Authors: Bich Ngo T.Ngoc
Published: January 2022

Thực trạng khai thác thủy sản của Việt Nam giai đoạn 2018-2020
PERANAN OSIS DALAM MEMBENTUK KARAKTER PEDULI SOSIAL SISWA DI SMA NEGERI 3 BARRU
Authors: Yusmuliadi  , Agustang Andi
Published: January 2022

Penelitian ini bertujuan untuk mengetahui peranan OSIS dalam membentuk karakter peduli sosial siswa di SMA Negeri 3 Barru dan untuk mengetahui hambatan OSIS dalam membentuk karakter peduli sosial siswa di SMA Negeri 3 Barru. Jumlah informan pada penelitian ini sebanyak 18 orang yang ditentukan melalui teknik purposive sampling dengan kriteria kepala sekolah, wakil kepala sekolah bidang kesiswaan, pembina OSIS, pengurus aktif OSIS dan siswa yang bukan pengurus OSIS. Teknik pengumpulan data yang dilakukan yaitu observasi, wawancara, dan dokumentasi. Teknik analisis data kualitatif tipe deskriptif melalui tiga tahap yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Teknik pengabsahan data menggunakan triangulasi sumber. Hasil penelitian menunjukkan bahwa peranan OSIS dalam membentuk karakter peduli sosial siswa di SMA Negeri 3 Barru yaitu dengan membuat dan melaksanakan program kerja berbasis kegiatan sosial, menggerakkan atau memotivasi siswa pada kegiatan sosial, dan mencegah terjadinya penyimpangan di sekolah. Hambatan OSIS dalam membentuk karakter peduli sosial siswa di SMA Negeri 3 Barru yaitu kurangnya kesadaran sosial siswa, egoisme etis siswa, pengaruh lingkungan luar sekolah, dan kondisi ekonomi siswa.
Improving the Utility and Usability of Visualization in AI-driven Scientific Discovery
Authors: Wang Qianwen , L'Yi Sehi , Gehlenborg Nils
Published: January 2022

Visualization plays a critical role in XAI due to its efficiency in organizing and communicating information. However, current visualizations are designed mainly for AI researchers and offer little to no support for domain experts such as biologists or clinicians. Failing to consider the perspective of users and the characteristics of the applied research domains can significantly undermine the utility and usability of visualizations and explanations. We discuss the challenges and opportunities about the utility and usability of visualization in AI-driven scientific discovery.
Pemuatan Konten Pandemi dalam Pembelajaran IPS
Authors: Widiawaty Millary Agung , Dede Moh.
Published: January 2022

Pembelajaran IPS bertanggungjawab dalam membentuk peserta didik sebagai anggota masyarakat yang tanggap terhadap pandemi. Karakteristik khas IPS sebagai subjek pembelajaran mampu dikembangkan dan memuat konten pandemi melalui sejumlah penambahan atau perubahan kompetensi dasar di setiap jenjang pendidikan. Konten pandemi dapat ditinjau dari sisi kemunculan, lingkungan penyebaran, dampak sosial-ekonomi, serta respons sosial-ekonomi-politik yang bermanfaat untuk membentuk wawasan, sikap, maupun keterampilan peserta didik menuju good citizenship. Pemuatan konten pandemi seharusnya bukan hanya muncul sebagai reaksi sesaat dunia pendidikan nasional, melainkan pula perlu dikuatkan dalam standar baku dan pembaharuan di dalam kurikulum.
Intraindividual Changes in Political Identity Strength (but not Direction) are Associated with Political Animosity in the United States and the Netherlands
Authors: Brandt Mark John , Vallabha Shree
Published: January 2022

We test if within-person changes in political identities are associated with within-person changes in political animosity in two longitudinal studies (USA N = 552, Waves = 26; Netherlands N = 1670, Waves = 12). Typical studies examine cross-sectional associations without assessing within-person change. Our work provides a stronger test of the relationship. We find that within-person changes in the strength of people’s ideological and partisan identities are associated with increased political animosity. We found no such associations with within-person changes in identity direction. These patterns were robust to covariates and emerged in both studies. In addition to these average effects, we found substantial heterogeneity across participants in the associations between identity strength, identity direction, and political animosity. We did not find robust and replicable moderators for this heterogeneity. These findings suggest that identity strength (but not identity direction) is a key, if heterogenous, factor in changes in political animosity.