bluuebunny/crossref_metadata_2025 huggingface dataset:
A High-Performance Workflow for Identifying Site-Specific Crosslinks Originating from a Genetically Incorporated, Photoreactive Amino Acid
Authors: Ulmer Lindsey D. , Canzani Daniele , Woods Christopher N. , Stone Natalie L. , Janowska Maria K. , Klevit Rachel E. , Bush Matthew F.
Published: June 2024

In conventional crosslinking mass spectrometry, proteins are crosslinked using a highly selective, bifunctional chemical reagent, which limits crosslinks to residues that are accessible and reactive to the reagent. Genetically incorporating a photoreactive amino acid offers two key advantages: any site can be targeted, including those that are inaccessible to conventional crosslinking reagents, and photoreactive amino acids can potentially react with a broad range of interaction partners. However, broad reactivity imposes additional challenges for crosslink identification. In this study, we incorporate benzoylphenylalanine (BPA), a photoreactive amino acid, at selected sites in an intrinsically disordered region of the human protein HSPB5. We report and characterize a workflow for identifying and visualizing residue-level interactions originating from BPA. We routinely identify 30 to 300 crosslinked peptide spectral matches with this workflow, which is up to ten times more than existing tools for residue-level BPA crosslink identification. Most identified crosslinks are assigned to a precision of one or two residues, which is supported by a high degree of overlap between replicate analyses. Based on these results, we anticipate that this workflow will support the more general use of genetically incorporated, photoreactive amino acids for characterizing the structures of proteins that have resisted high-resolution characterization.
Spectroscopic Characterization of the Complexes of 2-(2′-Pyridyl)-Benzimidazole and (H2O)1,2, (CH3OH)1,2, and (NH3)1,2 Isolated in the Gas Phase
Authors: Sen Arkaprabha , Khodia Saurabh , Jarupula Ramesh , Baweja Simran , Kalal Bhavika , Maity Surajit
Published: June 2024

The present article presents a comprehensive laser spectroscopic characterization of 2-(2′-Pyridyl)-Benzimidazole (PBI)-S1,2 complexes (S = H2O, CH3OH, and NH3) isolated in the gas phase. The study aimed to understand docking preference of small molecules on N-bearing bio-relavent multifunctional molecules. Based on the LIF and R2PI spectroscopy, we have identified two distinct isomers of 1:1 (PBI-H2O) and 1:2 (PBI-(H2O)2) complexes. In the cases of PBI-CH3OH and PBI-NH3 systems, a single 1:1 and 1:2 complex was identified in each case. Computational analyses predicted the most stable structure, labelled as PBI-S-a with NIH···S and SH···NP (NIH = imidazolyl NH and NP: Pyridyl-N) hydrogen bonds at site-a. The structures were associated with significantly higher stability of the S1 state (D0(S1)>D0(S0)) compared to that in the corresponding ground states. The structure of PBI-H2O-b isomer, with CPH···S and SH···NI hydrogen bonds, was characterized by a blue-shifted band origin transition, validating computational predictions. The PBI-(S)2-aa (S=H2O, CH3OH, and NH3) isomers exhibited large red-shifted S0→S1 band origins, as predicted computationally. A unique PBI-(H2O)2-ab isomer was detected with a significantly lowered redshifted band origin transition compared to the aa-isomer, in which a solvent molecule is bound to the sites a and b PBI molecule. Notably, PBI-H2O complexes exhibit solvent-to-chromophore proton transfer reactions, with varying energy barriers depending on the isomeric configuration. The energy barriers for proton transfer reactions in PBI-H2O-b isomers demonstrated significantly elevated barriers (> 800 cm-1). In PBI-(H2O)-aa, the energy barrier (>436 cm-1) is marginally elevated from 420±10 cm-1 in PBI-H2O-a isomer. This study enhances the understanding of complex molecular interactions and provides insights into the excited-state processes, laying the groundwork for further investigations.
TADF mechanism in a carbene-copper emitter: Insights from the nuclear ensemble simulations
Authors: de Thieulloy Laure , de Sousa Leonardo Evaristo , de Silva Piotr
Published: June 2024

We use the nuclear ensemble approach to study the mechanism of thermally activated delayed fluorescence (TADF) in a carbene-copper-amide (CMA1) emitter. The results obtained for the emitter in the gas phase are consistent with previously published surface hopping non-adiabatic dynamics simulations for the same system. CMA1 has two excited-state conformations with distinct excited state dynamics. For both conformations, the intersystem crossing (ISC) from the S1 state occurs via higher-lying triplets, but the reverse ISC (rISC) can occur exclusively in the perpendicular orientation of the ligands, directly between the T1 and S1 states. Non-adiabatic mixing with higher triplet states is not required for efficient rISC, but T1 changes diabatic character significantly along the vibrational modes. Furthermore, we find that the inclusion of the solvent effects has a significant impact on the TADF mechanism, enabling rISC in both conformations. The calculated rate constants and lifetimes are within an order of magnitude of the experimental values.
In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury
Authors: Lagiakos H. Rachel , Zou Yefen , Igawa Hideyuki , Therrien Eric , Lawrenz Morgan , Kato Mitsunori , Svennson Mats , Gray Felicia , Jensen Kristian K. , Dahlgren Markus K. , Pelletier Robert D. , Dingley Karen H. , Bell Jeffrey A. , Jiang Yuansong , Zhou Hua , Skene Robert J. , Nie Zhe
Published: June 2024

Dual leucine zipper kinase (DLK), expressed primarily in neuronal cells, is a regulator of neuronal degeneration in response to cellular stress from chronic disease or neuronal injury. This makes it an attractive target for the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis; and neuronal injury, such as chemotherapy induced peripheral neuropathy. Here we describe the discovery of a potent, selective, brain-penetrant DLK inhibitor, KAI-11101 (59). Throughout the program's progression, medicinal chemistry challenges such as potency, hERG inhibition, CNS penetration, CYP3A time-dependent inhibition, and kinase selectivity were overcome through the implementation of cutting-edge in silico tools. KAI-11101 displayed an excellent in vitro safety profile and showed neuroprotective properties in an ex vivo axon fragmentation assay as well as dose-dependent activity in a mouse PD model.
Quantitative Analysis of Atom Economy Using Reaction SMILES: A Computational Approach
Authors: Baffelli Simone , Giani Samuele
Published: June 2024

We present an implementation of the algorithm for calculating the atom economy of chemical reactions using reaction SMILES. Python programming is used to interface the RDKit library to parse and interpret chemical structures, providing accurate and efficient chemical sustainability computations. By implementing a robust algorithm to handle stoichiometric coefficients and multiple reactions, the approach provides a comprehensive analysis of atom economy, a metric essential for green chemistry practices. Additionally, this calculation approach can be easily integrated into AI applications that generate a large amount of chemical reactions, as a screening and optimization step, further enhancing the potential for sustainable chemical process design. We demonstrate its application through several case studies, highlighting its potential to aid in the design of more sustainable chemical processes.
Metal-Free Site-Selective Functionalization with Cyclic Diaryl λ3-Chloranes: Suppression of Benzyne Formation for Ligand-Coupling Reactions
Authors: Patra Koushik , Dey Manas Pratim , Baidya Mahiuddin
Published: June 2024

While hypervalent halogens are versatile reagents enabling diverse reactions in organic synthesis, the utility of hypervalent chlorine compounds, particularly cyclic λ3-chloranes, remains underdeveloped despite their unique electronic properties and innate enhanced reactivity. Herein, we illustrate the elusive ligand coupling reaction of cyclic λ3-chloranes that suppresses the more facile competing reaction modality involving benzyne intermediates. The methodology can be performed in three-component as well as two-component fashion, offering direct access to a wide range of unsymmetrically substituted biaryl molecules in very high yields and excellent ortho-regioselectivity. The reactions were scalable, and the versatility was demonstrated by constructing different types of C–S and C–N bonds under mild conditions. The reaction outcomes were also compared with corresponding λ3-iodanes and λ3-bromanes, demonstrating the superiority of cyclic λ3-chloranes in ligand-coupling reactions under metal-free conditions.
PENDAMPINGAN GURU DALAM PENGEMBANGAN MULTIREPRESENTATION MOBILE BASED ASSESSMENT UNTUK MENDUKUNG MERDEKA BELAJAR
Authors: Amiroh Dewi , Masrifah Masrifah
Published: June 2024

Kegiatan pengabdian kepada masyarakat dilakukan untuk meningkatkan kemampuan guru SMA  mengembangkan mobile based assessment MBA sesuai mata pelajaran yang diampu yaitu Fisika, Kimia, dan Matematika dengan pengembangan soal pilihan ganda. Kegiatan ini bermitra dengan guru SMA Negeri 4 Ternate yang berjumlah 15 guru yang dikelompokkan menjadi tiga sesuai mata pelajaran yang diampu. Pengabdian dilaksanakan pada bulan Oktober 2023 berupa pelatihan serta bimbingan praktis melalui metode diskusi interaktif dengan penugasan. Instrumen pengabdian berupa lembar observasi, angket, serta lembar tugas. Hasil observasi menunjukkan bahwa seluruh peserta menjalin komunikasi dengan baik serta membantu dalam penyelesaian tugas, bertanggung jawab dalam menyelesaikan tugas pengembangan penilaian multirepresentasi dengan mobile based serta seluruh anggota kelompok berperan aktif. Hasil angket disimpulkan semua guru peserta mengikuti kegiatan pengabdian memperhatikan serta meninjau kembali materi ajar saat penyusunan soal multirepresentasi. Sebagian guru sudah pernah menggunakan penilaian mobile based dengan google form dan mengetahui ragam soal multirepresentasi, sedangkan sebagian yang lain belum pernah menggunakan penilaian mobile based dan belum mengetahui cara mengembangkan soal multirepresentasi. Hasil akhir pengabdian menunjukkan bahwa semua guru telah berhasil mengembangkan multirepresentasi MBA berupa soal pilihan ganda. Pelatihan pengembangan multirepresentasi MBA ini perlu dilanjutkan dan disebarluaskan kepada seluruh guru di sekolah tersebut mupun pada sekolah lainnya.
Information Technology and the Complexity Cycle
Authors: R Gill Thomas , Gill Grandon
Published: June 2024

Aim/Purpose: In this paper we propose a framework identifying many of the unintended consequences of information technology and posit that the increased complexity brought about by IT is a proximate cause for these negative effects.

Background: Builds upon the three-world model that has been evolving within the informing science transdiscipline.

Methodology: We separate complexity into three categories: experienced complexity, intrinsic complexity, and extrinsic complexity.

With the complexity cycle in mind, we consider how increasing complexity of all three forms can lead to unintended consequences at the individual, task and system levels. Examples of these consequences are discussed at the individual level (e.g., deskilling, barriers to advancement), the task level (e.g., perpetuation of past practices), as well as broader consequences that may result from the need to function in an environment that is more extrinsically complex (e.g., erosion of predictable causality, shortened time horizons, inequality, tribalism).

We conclude by reflecting on the implications of attempting to manage or limit increases of complexity.

Contribution: Shows how many unintended consequences of IT could be attributed to growing complexity.

Findings: We find that these three forms of complexity feed into one another resulting in a positive feedback loop that we term the Complexity Cycle. As examples, we analyze ChatGPT, blockchain and quantum computing, through the lens of the complexity cycle, speculating how experienced complexity can lead to greater intrinsic complexity in task performance through the incorporation of IT which, in turn, increases the extrinsic complexity of the economic/technological environment.

Recommendations for Practitioners: Consider treating increasing task complexity as an externality that should be considered as new systems are developed and deployed.

Recommendation for Researchers: Provides opportunities for empirical investigation of the proposed model.

Impact on Society: Systemic risks of complexity are proposed along with some proposals regarding how they might be addressed.

Future Research: Empirical investigation of the proposed model and the degree to which cognitive changes created by the proposed complexity cycle are necessarily problematic.
The effect of preoperative training provided to patients undergoing coronary artery bypass graft surgery on postoperative comfort
Authors: Şahin Ayşe , Dığın Figen
Published: June 2024

Background/Aim: The most popular surgical procedure for treating coronary artery diseases is coronary artery bypass graft surgery. However, the comfort that patients experience after coronary artery bypass graft surgery varies considerably. The purpose of this study is to ascertain the impact of preoperative training on postoperative comfort in patients undergoing coronary artery bypass graft surgery.
Methods: This study was conducted as a quasi-experimental research investigation the cardiovascular surgery clinic of Edirne Sultan Murat I State Hospital from December 2019 through December 2020. It included 46 patients aged 18–65 who were undergoing their first coronary artery bypass graft surgery and volunteered to participate. The patients in the experimental group (23 individuals), were provided preoperative training; no interventions were made with the patients in the control group. The General Comfort Questionnaire was administered to all of the patients prior to discharge. The necessary ethical and institutional approvals were obtained before the study. Transparent Reporting of Evaluations with Non-randomized Designs was used as the research reporting guideline.
Results: The postoperative General Comfort Questionnaire total score (P<0.001), mean scores of all sub-dimensions (P<0.001) and comfort levels of the experimental group were higher than those of the control group (P<0.001). Preoperative training therefore had a positive impact on postoperative comfort level.
Conclusion: Preoperative training provided to patients improved their postoperative comfort. It is recommended that surgical nurses increase patient comfort by providing patient training before coronary artery bypass graft surgery and that nurses should be supported in administering patient training.
Artificial Neural Network-Based Prediction of Physical and Mechanical Properties of Concrete Containing Glass Aggregates
Authors: Maraqa Faroq , Yasin Amjad A. , Al-Sahawneh Eid , Alomari Jamal , Al-Adwan Jamal , Al-Elwan Ahmad A.
Published: June 2024

This comprehensive study analyzes the use of crushed glass as both fine and coarse aggregate in concrete, as well as the prediction accuracy of Artificial Neural Networks (ANN). The primary objectives are to understand the interactions between concrete’s constituents and to assess the accuracy of ANN models in predicting concrete’s mechanical and physical properties. This is achieved using a two-decade experimental results dataset of concrete’s compressive and tensile strengths, slump, density, and the corresponding mix design proportions, including waste glass aggregate. A series of 70 concrete samples were carefully built and tested, with compressive strengths varying from 12 to 71 MPa and glass aggregate percentages ranging from 0-100%. These samples served as the basis for the creation of an input dataset and ANN targets. The ANN model underwent intensive training, validation, testing, and statistical regression analysis. The ANN models are exceptionally accurate, with a continuously low error margin of roughly 2%, highlighting their usefulness in matching experimental and predicted results. Validation techniques highlight the models' dependability, with consistently high coefficients of determination (R-values), including 0.99484, demonstrating their robustness in replicating complicated concrete properties. The data analysis shows a unique pattern, with optimum glass aggregate percentages in the range of 10–20%. Beyond this range, there is a noticeable decline in concrete properties. Finally, the study confirms the efficacy of ANN in predictive modeling while also validating the potential of crushed glass to replace natural aggregates in concrete. Doi: 10.28991/CEJ-2024-010-05-018 Full Text: PDF
Unveiling the Impact of Psychological Factors on Consumer Purchase Intentions for Overall Sustainable Success in Green Residential Buildings: Using SEM-ANN Analysis
Authors: Zamil Ahmad M. , Kineber Ahmed Farouk , Alhusban Mohammad
Published: June 2024

The research problem addressed in this study is the limited understanding of the intricate interactions among emotional, environmental, and psychological factors within organizations and their collective impact on overall sustainable success (OSS). A critical gap exists in the literature, as previous studies often analyze these factors in isolation, leaving an incomplete picture of their interdependence. To fill this gap, this study aims to comprehensively understand the interplay between Psychological Factors (PF) and OSS. The objectives are to identify relevant factors, collect data, and employ a rigorous methodology for analysis. The research methodology involves a three-phase approach: factor identification, data collection, and analysis. This study leverages a unique integration of Structural Equation Modeling (SEM) and Artificial Neural Networks (ANN) to deepen the analysis, revealing intricate relationships among identified factors. The study's findings highlight a robust positive association between PF and OSS, underscoring the significance of prioritizing employees' psychological well-being for enhanced workplace satisfaction and performance. These insights have practical implications for organizational leaders and managers, guiding them to cultivate positive emotional climates, instill environmentally conscious practices, and address negative emotional states within their teams. Doi: 10.28991/CEJ-2024-010-05-07 Full Text: PDF
La Investigación Social en México, 2011. Tomo I
Authors: Serrano Aviles Tomas , Ortiz Lazcano Asael
Published: June 2024

Este trabajo analiza la situación de la investigación social en México. El esfuerzo reúne catorce sólidos temas y 11O artículos de gran variedad. El volumen contiene la publicación física de los artículos dados a conocer durante el Séptimo Congreso Nacional de Investigación Social, convocados por la Universidad Autónoma del Estado de Hidalgo, en el 2011
La Investigación Social en México, 2013. Tomo II
Authors: Ortiz Lazcano Asael
Published: June 2024

La estructura familiar y social ha sufrido una transformación radical en las últimas décadas, que sumado a la incorporación de la mujer al mercado laboral, el descenso de la fecundidad y las recurrentes dificultades económicas, no solo se ha constreñido la economía, además la familia y la sociedad se ha reconfigurado, y no necesariamente para mejorar el nivel de bienestar, por el contrario, para ver disminuida en mayor medida su situación económica y laboral.
Addressing multicollinearity in spatial modelling: A district level spatial analysis of pandemic COVID-19 in India.
Authors: Shalini Chandra  , Sharma Megha
Published: June 2024

This study focuses on conducting spatial analysis of COVID-19 at the district level in India. Leveraging data from www.covidindia.org for confirmed cases and deaths, and integrating population characteristics from the National Family Health Survey 5 (2019-2021) and supplementary sources. The objective is to identify risk factors using spatial modelling techniques while addressing multicollinearity through principal component analysis (PCA). This study utilizes spatial analysis to identify COVID-19 hotspots and coldspots at the district level in India. It highlights highly affected districts such as Mumbai, Pune, Chennai, Kolkata, and Bengaluru, as well as low affected districts in central and north-eastern regions. The study utilized the spatial lag model (SLM), spatial error model (SEM), geographical weighted regression (GWR), and multiscale geographical weighted regression (MGWR) models to analyse the impact of demographic, socioeconomic, climatic, and comorbidity factors on COVID-19, accounting for spatial proximity. Among these models, MGWR exhibited superior performance. Key risk factors associated with the COVID-19 phenomenon identified, providing insights into the impact of household conditions, educational level of women, tobacco and alcohol consumption rates, number of health centres, and climatic factors. Moreover, the local coefficients estimated by MGWR model furnish detailed information regarding the strength and direction of the relationships between predictors and COVID-19 cases and deaths within each spatial unit. The findings emphasize the significance of addressing multicollinearity in spatial modelling. It is beneficial for accurate parameter estimation, proper interpretation of coefficients, improved spatial analysis, and providing reliable insights to support decision-making in spatial contexts.
Mortalidad de Galleria mellonella L. por Beauveria bassiana (bálsamo) Vuill (Ascomycota: Hypocreales)
Authors: Hernández-Domínguez Carmela , Zamora-Bernardino Carmela , Vázquez-Cruz Fabiel , Reyes-López Delfino , Domínguez-Perales Luís A. , Enríquez García Fabián
Published: June 2024

Uno de los hongos más usado en el control de plagas, el cual tienen un amplio rango de hospedantes es Beauveria bassiana. Este entomopatógenos se ha adaptado a distintos ambientes y se puede encontrar en varios lugares, por lo que en el presente trabajo se colectaron 60 muestras de suelo en Acatlán de Pérez Figueroa, Oaxaca, por medio de Galleria mellonella utilizado como cebo para su aislamiento, en el año 2020. De este procedimiento se obtuvieron cinco aislados los cuales se evaluaron en larvas de Galleria mellonella a 24, 48, 72, 96, 120,144 y 168 h con el fin de conocer su eficacia en mortalidad y micosis. En la metodología se extrajo el ADN de los hongos y la región ITS del gen 5.8S rRNA fue amplificada por PCR, el producto fue secuenciado y las secuencias fueron comparadas con otras existentes en el centro nacional para la información biotecnológica. El resultado fue un aislado de Beauveria pseudobassiana y cuatro de Beauveria bassiana de los cuales el 11 presentó 100% de mortalidad y micosis a las 96 h a diferencia del aislado comercial y el testigo los cuales necesitaron 72 h adicionales para matar la totalidad de larvas, además de presentar 20% y 60% de micosis respectivamente. El tiempo de 96 h fue significativamente diferente (p≤ 0.05) debido a que en éste murió la mayoría de las larvas y hubo micosis. Identificar hongos entomopatógenos y realizar estudios de su efectividad en larvas facilita el inicio de nuevos experimentos en la investigacion.
Princípios básicos de Simulação Estocástica aplicados a Seguros
Authors: Ferreira Leandro , Pires Danilo Machado , Marques Reinaldo Antonio Gomes
Published: June 2024

Um atuário pode estar interessado numa determinada informação contida em um modelo que envolva variáveis aleatórias. Quando não se dispõe de uma solução analítica para esse modelo ou não se tem acesso a um banco de dados adequado, a simulação de variáveis aleatórias surge como uma abordagem viável. Muitos problemas em Ciências Atuariais envolvem a área de Estatística Computacional, como na análise de modelos de perdas em seguros. A presente obra se destina aos alunos dos cursos de graduação em Ciências Atuariais, onde poderão conhecer a Estatística Computacional com aplicações em seguros.
Agro-morphological Growth Response of Acha (Fonio) (Digitaria Exilis and Digitaria Iburua [Kippist] Stapf.) Exposed to Colchicine: Leaf Length, Leaf Width and Leaf Area Index
Authors: Nyam DD , Gonzuk NS , Sila MD , Tumba YC , Angyu EA , Kwon-Ndung EH
Published: June 2024

The present study investigated the effects of colchicine treatment on leaf length, leaf width, and leaf area index (LAI) in two species of Acha (fonio), namely Digitaria exilis and Digitaria iburua. Colchicine, a potent mitotic inhibitor, has been widely used to induce polyploidy and in studying the effects of genome duplication on various morphological traits. This study aimed to explore if colchicine treatment could alter the leaf morphology of the two Acha species. Seeds of the two species were treated with colchicine solution at various concentrations (0.05, 0.10, 0.15, and 0.20 g/dL), while a control group was maintained without any treatment. Leaf length and width were measured using a meter rule, and LAI was calculated by multiplying the leaf length and leaf width with the constant for both species. Statistical analysis was performed using the Analysis of Variance on SPSS to determine significant differences between treated and control groups. The results showed that colchicine treatment had a significant effect on leaf morphology in both Acha species. Leaf length and width increased significantly in response to colchicine treatment, with the degree of increase depending on the concentration. Moreover, the LAI also exhibited a significant increase in treated plants compared to the control group. Colchicine concentration level of 0.10 g/dL produced the best results that can be exploited to enhance the morphological characteristics of both Acha species. The findings suggest that colchicine-induced polyploidy can enhance leaf growth and overall leaf area in Acha plants, leading to potential implications for agricultural productivity and yield improvement. Further studies are needed to elucidate the underlying mechanisms and long-term effects of colchicine-induced polyploidy on other growth parameters, reproductive traits, and yield in Acha. Understanding the genetic and physiological changes associated with polyploidy in Acha species will contribute to the development of improved breeding strategies and cultivation practices for this important cereal crop.
Fatal Immune Checkpoint Inhibitor-associated Myocarditis Mimicking Infiltrative Cardiomyopathy in a 54-year-old Woman with Metastatic Melanoma
Authors: Hichem Sakhi , Virgile Chevance , Laurette Kalifa , Riad Arana , Ariane Laparra , Guillaume Reverdito , Fares Ben Salem , Charles Pottier , Olivier Lambotte , Arshid Azarine , Sondes Smaali
Published: June 2024

Introduction: Immune checkpoint inhibitors (ICI) have significantly improved cancer treatment outcomes, but cardiovascular complications such as ICI-associated myocarditis are a major concern. Diagnosing myocarditis requires integrating biomarkers, electrocardiogram (EKG), cardiac imaging, and endomyocardial biopsy. We present a case illustrating these diagnostic challenges, involving a female patient treated with pembrolizumab who developed fatal acute myocarditis mimicking infiltrative cardiomyopathy. Case report: A 54-year-old woman with mucosal melanoma, treated with pembrolizumab, was hospitalized in May 2023 due to dyspnea and elevated troponin levels. Initial cardiac workups were normal, but subsequent tests revealed borderline cardiac magnetic resonance imaging findings. In late May 2023, the patient was admitted with worsening dyspnea, elevated NT-pro-BNP, and severe hyperlactatemia. Imaging and endomyocardial biopsy confirmed acute myocarditis with atypical presentation, mimicking infiltrative cardiomyopathy. Despite aggressive immunosuppressive therapy, the patient’s condition deteriorated, resulting in cardiogenic shock and death seven days post-admission. Conclusion: This case underscores the diagnostic and management challenges of ICI-associated myocarditis, particularly with atypical presentations. It highlights the need for vigilant, comprehensive monitoring and further research to improve diagnostic and therapeutic strategies for managing these severe side effects in patients undergoing ICI therapy.
Knowledge and attitude towards the acceptance of vaccination against COVID-19 among healthcare professionals in Morocco
Authors: Baba Mohamed Amine , Bigi Soufiane , Edhaim Aya , Bimouh Hind , Naciri Aziz , Achbani Abderrahmane , Abderrahmane Arechkik , Kharbach Ahmed
Published: June 2024

Objectives: To assess the knowledge and acceptance of health professionals in the southern region of Morocco in relation to the anti-COVID-19 vaccines.

Methods: This cross-sectional observational study will make it possible to assess the state of knowledge and acceptance of the vaccine against COVID-19 among health personnel in the prefecture of Agadir Idaoutanane, and to determine the factors influencing them, thanks to a self-administered questionnaire. Vaccine acceptance was determined by individuals who opted for vaccination willingly.

Results: A total of 390 health professionals participated in this study. According to the results, there is a predominance of the female sex with a percentage of 63.2% and a sex ratio equal to 0.57. In addition, more than half of the health personnel participating in this study were between the ages of 20 and 30. 365 health professionals (93.3%) were vaccinated against COVID-19 of which 53.1% chose to be vaccinated of their own free will. Multivariate analysis revealed that age, and the question of the development of immunity to COVID-19 are significantly associated with vaccine acceptance.

Conclusions: These observations are worrying insofar as health personnel have frequent and prolonged contact with patients. Hence the importance of improving their state of knowledge and positively impacting their acceptance of anti-COVID-19 vaccines in order to influence the attitude of their patients and the rest of the population.
Understanding the impact of climate change on Bhutanese school communities: Challenges and responses
Authors: Thapa Ramesh , Gough Annette , Cooper Grant
Published: June 2024

Climate change is intensifying the risks faced by children’s lives, as well as impacting their learning and education. How school communities in Bhutan are dealing with issues related to climate change is largely uncharted. This study examined how Bhutanese schools have been affected by the changing climate and how they were responding to it. The data sources included interviews with school principals, teachers, and district education officers, as well as observations, and document analysis. The global comprehensive school safety framework, along with a whole school approach to climate action framed the results of this study. Findings included that schools experienced multiple climate impacts and shocks affecting their children’s health, education, and the school system itself. Adaptation and mitigation measures including climate change education have yet to gain traction at the sector and school’s level. Schools, however, have attempted some actions such as through disaster management, and participatory environmental conservation and green school initiatives. Social capital was critical in filling the resource gap for initiating environmental and climate change actions, carried out through collective school, community, and student-based activities. Human capacities, policy and institutional structures, technical capacities, and capital (cultural and economic) constraints as well as slow mainstreaming into local development processes impeded efforts to build climate-resilient schools, including practices to contribute to greenhouse gases reduction. This study not only shed light on how climate change was affecting schools and children but also provided strong evidence for policymakers and relevant agencies to scale up interventions to enhance adaptation and mitigation practices.
THE «STATE SECURITY» CONCEPT COMPONENTS IN THE DEVELOPMENT OF MECHANISMS FOR ITS PROVIDING IN UKRAINE
Authors:   Khmelnytskyi National University, Krupa Oleksandr
Published: June 2024

Security issues are one of the central in any sphere of human activity and in general in the aspect of ensuring the humanity existence and development, which determines the presence of scientists' persistent interest in security issues over the centuries. Not an exception is the study of the issues of state security, the basic foundations of which have been substantiated since the time of the first state formations. The modern spectrum of research into the issues of state security is constantly expanding and being supplemented with new aspects and directions due to the development of societies and international relations, however, scientific theory does not operate with definitions of individual categories and concepts in the field of security that would be generally accepted in the world scientific discourse. Taking into account the fact that the formation of effective mechanisms for ensuring state security and the results of their implementation will, first of all, be determined by the interpretation of the conceptual apparatus of security, on the basis of which they were formed, under these conditions, the study of the content features and the conceptual-categorical apparatus of the "state security" concept acquires special importance. In the course of the study were considered the main content aspects of the category "security" in their diversity and highlighted the key approaches to the interpretation of its essence in scientific sources. Conducted a comparative analysis of views in Ukrainian and English-language scientific works on the essence of the categories "state security " and "national security" and characterized the key critical remarks in the Ukrainian discourse regarding the expediency of their application. Defined and characterized the list of the "state security" concept components in the development of mechanisms for its providing.
DIGITAL TRANSFORMATION OF BUSINESS IN UKRAINE: CURRENT TRENDS, CHALLENGES AND PROSPECTS
Authors:   Varna University of Management, Mostova Anastasiia , Kapiton Alla ,   National University “Yuri Kondratyuk Poltava Politechnics”, Baranova Valeriia ,   Education and Research Institute “Karazin Banking Institute” V.N. Karazin Kharkiv National University
Published: June 2024

The paper examines the main trends in the global digital economy. The theoretical foundations of the digital transformation of business are considered. The indicators of digital transformation of large and small enterprises in the EU were studied. Ukraine's position in international “digital” rankings was studied; the gaps and weaknesses in Ukraine’s digital competitiveness were studied. The main indicators of digital transformation of Ukrainian enterprises are analyzed. The prospects for the further digital transformation of enterprises and directions for the development of the infrastructure supporting digital projects are shown. The main initiatives of the Ukrainian government and stakeholders in the development of the digital economy and digital transformation, the construction of ecosystems supporting ICT innovations and startups in Ukraine were studied. The factors influencing the acceleration of digital transformation of business, such as the development of the IT sector, the construction of a powerful infrastructure, the system of education and support for innovations and startups, have been thoroughly investigated. The main problems and directions of further development of the digital transformation of SMEs in Ukraine have been determined.
The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit
Authors: Çınar Harun
Published: June 2024

The aim of this study was to investigate and evaluate the effects of colloidal silver and hypochlorous acid solutions on wound healing. To evaluate the wound healing activity of colloidal silver solution and hypochlorous acid solutions, an in vivo excisional wound model was applied in New Zealand rabbits (n = 21). The rabbits were randomly divided into 3 groups with seven individuals in each group. Group 1 was used as a negative control and no treatment was applied. Groups 2 and 3 were treated with crystalline (hypochlorous acid) and colloidal silver, respectively. The treatments were applied topically (in the form of spray) to the wound area of each rabbit daily. Wound diameters were measured on days 4, 8 and 12 using calipers and histopathological examinations were performed on days 4, 8 and 12 of the treatment. In terms of wound closure, both hypochlorous acid and colloidal silver solutions showed comparable wound healing activity with the control group. In conclusion, hypochlorous acid and colloidal silver have a positive effect on dermal wound healing in rabbits.
Pelatihan Pengelasan Dan Perawatan Kapal Nelayan Bagi Masyarakat Nelayan Keputih Timur Gang Pompa Kecamatan Sukolilo Surabaya
Authors: Marsudi Sugeng , Awwalin Rodlitul , Mursidi  , Atmojo Gatot Priyo Tri
Published: June 2024

Pelatihan Pengelasan dan Perawatan Kapal Nelayan merupakan inisiatif untuk meningkatkan keterampilan dan pemahaman teknis masyarakat nelayan di Keputih Timur, Gang Pompa, Kecamatan Sukolilo, Surabaya. Program ini bertujuan memberikan pengetahuan yang mendalam tentang teknik pengelasan yang aman dan efektif, serta praktik perawatan kapal yang berkelanjutan. Materi pelatihan mencakup teknik pengelasan dasar, identifikasi dan perbaikan kerusakan kapal, serta pencegahan korosi. Dengan melibatkan partisipasi aktif dari masyarakat nelayan, pelatihan ini dirancang untuk meningkatkan keberlanjutan usaha perikanan lokal. Hasilnya diharapkan dapat memberikan manfaat ganda: meningkatkan keamanan dan kualitas kapal nelayan, dan pada gilirannya, meningkatkan hasil tangkapan dan keberlanjutan ekosistem laut.
Analisis Kemampuan Pemecahan Masalah dalam Penyelesaian Soal Polinomial
Authors: Sarirah Fathimah Husna , Nurmalasari Meilita
Published: June 2024

Artikel ini membahas metode dan teknik untuk menentukan akar-akar persamaan polinomial menggunakan bilangan kompleks. Penelitian ini bertujuan untuk menganalsisi kemampuan mahasiswa dalam memecahkan masalah polinomial. Analisis deskriptif dilakukan untuk mengetahui kemampuan mahasiswa berdasarkan hasil kerja mereka.. Hasil penelitian menunjukkan beberapa mahasiswa mengalami kesulitan dalam menjawab soal polinomial karena penerapan strategi pemecahan yang kurang tepat dan lemah dalam pemeriksaan hasil akhir. Sebagaimana yang dilakukan oleh subjek (S-6) menunjukkan bahwa dalam penentuan akar-akar polinomial menggunakan bilangan kompleks menawarkan pendekatan yang lebih umum dan kuat dibandingkan hanya menggunakan bilangan real. Namun disisi lain subjek (S-6) dalam menyelesaikan masalah polynomial masih mengalami kesulitan dengna beberapa kesalahan. Meskipun pada awalnya subjek (S-6) berusaha menggunakan metode subtitusi dan faktorisasi. Meskipun demikian, perlu dipahami bahwa dalam kasus tertentu, metode faktorisasi mungkin tidak dapat diterapkan secara langsung atau membutuhkan analisis lanjutanSaran dari penelitian ini diharapkan mahasiswa dapat menerapkan langkah-langkah pemecahan masalah dengan disiplin sengingga dapat mengurangi tingkat kesalahan dalam menyelesaikan persamaan polinomial dengan melibatkan bilangan kompleks.
Design of an IMU-based Wearable System for Attack Behavior Recognition and Intervention
Authors:   Korean Institute of Smart Media, Jung Woosoon , Jeong Kyunman , Ryu Jeong Tak , Park Kyoung-Ock , Oh Yoosoo
Published: June 2024

The biggest type of behavior that prevents people with developmental disabilities from entering society is aggressive behavior. Aggressive behavior can pose a threat not only to the personal safety of the person with a developmental disability, but also to the physical safety of others. In this study, we propose a wearable system using a low-power processor. The proposed system uses an IMU (Inertial Measurement Unit) to analyze user behavior, and when attack behavior is not detected for a certain period of time through an LED array attached to the developed system, an interesting LED is displayed. By expressing patterns, we provide behavioral intervention through compensation to people with developmental disabilities. In order to implement a system that must be worn for a long time in a power-limited environment, we present a method to optimize performance and energy consumption across all stages, from data preprocessing to AI model application.
스마트 글래스 기반 Design and implementation of a smart glass-based emergency tele-medical direction system응급원격의료지도 시스템 설계 및 구현
Authors:   Korean Institute of Smart Media, Lee Youngho , Hwang Incheol , Yang Hyunmo , Park Gunwoo , Lee Sungmin
Published: June 2024

This paper proposes a smart glass-based emergency tele-medical direction system. This system is designed for hospital specialists to provide remote medical guidance to on-site coast guards or emergency responders. To identify the requirements necessary for system development, relevant technological trends and case studies were analyzed. Based on this analysis, three system requirements were defined: 1) The system must be able to determine the necessity of patient transport, 2) It should assist in providing emergency medical care during transport to the hospital, and 3) It must be capable of transmitting patient information to medical facilities. A prototype that meets these requirements was developed and its usability was evaluated.
Augmented Reality based Learning System for Solid Shapes
Authors:   Korean Institute of Smart Media, Mun Yeji , Kim Daehwan , Jo Dongsik
Published: June 2024

Recently, realistic contents such as virtual reality(VR) and augmented reality(AR) are widely used for education to provide beneficial learning environments with thee-dimensional(3D) information and interactive technology. Specially, AR technology will be helpful to intuitively understand by adding virtual objects registered in the real learning environment with effective ways. In this paper, we developed an AR learning system using 3D spatial information in the 2D based textbook for studying math related to geometry. In order to increase spatial learning effect, we applied to solid shapes such as prisms and pyramids in mathematics education process. Also, it allows participants to use various shapes and expression methods (e.g., wireframe mode) with interaction. We conducted the experiment with our AR system, evaluated achievement and interest. Our experimental study showed positive results, our results are expected to provide effective learning methods in various classes through realistic visualization and interaction methods.
Training Feedback effect of team-based CPR using a mobile video recording device body camera
Authors:   Korean Institute of Smart Media, Im Seong bin
Published: June 2024

This study conducted a team-based CPR simulation with 32 fourth-year emergency rescue students to determine the effectiveness of training feedback using body cameras used at emergency rescue sites, and measured awareness, training feedback effectiveness, and satisfactio+n before and after body camera feedback. , preferences and difficulties in using body camera devices were identified. Data analysis was performed using SPSS 27.0 program, including descriptive statistics, frequency analysis, paried t-test, and Wilcoxon signed rank test. As a result of the study, the perception of body camera use showed a positive change from 3.73±0.62 points to 4.45±0.54 points, and a positive satisfaction level of 3.98±0.51 was shown (p<.001). Additionally, there was a significant increase in self-check accuracy and performance score after body camera feedback (p<.001). Therefore, during team-based simulation resuscitation training, positive feedback effects in improving self-inspection ability and performance can be achieved by watching body camera videos and using self-checklists without direct feedback from the instructor.
CenterTrack-EKF: 확장된 칼만 CenterTrack-EKF: Improved Multi Object Tracking with Extended Kalman Filter필터를 이용한 개선된 다중 객체 추적
Authors:   Korean Institute of Smart Media, Yang Hyun-Sung , Sim Chun-Bo , Jung Se-Hoon
Published: June 2024

Multi-Object trajectory modeling is a major challenge in MOT. CenterTrack tried to solve this problem with a Heatmap-based method that tracks the object center position. However, it showed limited performance when tracking objects with complex movements and nonlinearities. Considering the degradation factor of CenterTrack as the dynamic movement of pedestrians, we integrated the EKF into CenterTrack. To demonstrate the superiority of our proposed method, we applied the existing KF and UKF to CenterTrack and compared and evaluated it on various datasets. The experimental results confirmed that when EKF was integrated into CenterTrack, it achieved 73.7% MOTA, making it the most suitable filter for CenterTrack.
THE ROLE OF MUSIC FESTIVALS IN SHAPING DESTINATION BRANDING AND IMAGE IN TWO HUNGARIAN REGIONAL CENTERS
Authors:   University of Szeged, Department of Economic and Social Geography, Szeged, Hungary, SÜLI Dorottya , BOROS Lajos ,   University of Szeged, Department of Economic and Social Geography, Szeged, Hungary, PÁL Viktor ,   University of Szeged, Department of Economic and Social Geography, Szeged, Hungary
Published: June 2024

Urban marketing with culture-led urban development has a growing importance for contemporary cities. In a global competition, cities must stand out and attract tourism, investment, and cultural activities. Consequently, their image should be constantly improved. City branding provides strategies for enhancing a city's public image – thus, becoming more and more attractive. Events and festivals, like popular music festivals, offer valuable opportunities for promoting cities and boosting tourism. The aim of this research is to explore the potential of music festivals in building city image and integrating it into the broader branding processes. The results are based on semi-structured interviews and a questionnaire survey. The findings support the hypothesis that festivals can significantly raise destination awareness, and shape image, and through them, a wider audience can be reached. Festival uniqueness and appropriate venue choices facilitate seamless integration into the host city 's tourism – thus decision-makers should pay attention to this issue and facilitate coordination between stakeholders.