Abstract P5-01-11: PEM tests will have a high accuracy detecting breast cancer, if an individualized dosage of F-18-FDG is used
Authors: Müller Frank HH , Michael Hentschel , Müller Anton G , Farahati Jamshid 
Published: May 2015

Introduction: The diagnostic performance of the first European PEM (PET mammography) is based on individualized dosage of FDG evaluated in 108 females with 166 suspected breast lesions.

Methods: PEM imaging of the breast was performed in 108 consecutive females with 166 suspicious breast lesions or known breast cancer (BC) 90 min after i.v. application of 3.5 MBq/kg F-18-FDG per kg body weight. The maximum PEM uptake value (PUV) was derived from a ROI around the target lesion and was correlated with a corresponding non-target ROI in the contra lateral healthy breast to determine the target/non-target ratio (PUV-ratio). Images were analyzed by 2 experienced readers independently as compared to histopathology in all cases. The between group analyses for all malignant, benign and corresponding non-target lesions were calculated by paired Student t-Test. The mean target/non-target ratio in patients with BC compared to healthy patients was calculated by independent Student t-Test. Significance level was considered at p value &lt;0.05. Receiver operating characteristic (ROC) analyses were employed to determine associations with PUV and PUV-ratio.

Results: A total of 27 out of 166 (16.2%) lesions were malignant. Mean of PUV was estimated to be 3.9±2.5 in malignant lesions and 1.2±0.4 for the contra-lateral healthy breast (p&lt;0.001). The mean PUV-ratio in patients with BC of 3.4±1.5 was significantly higher as compared to benign lesions 1.2±0.3 (p&lt;0.001). The area under the ROC curve was 0.997 (0.000-1.000) for PUV and 0.986 (0.965-1.000) for PUV-ratio.

PEM was true-positive in 27 cases of cancers and false positive in 3 cases (papilloma, mastopathia bds.) considering a PUVmax &gt; 1,9, resulting in sensitivity of 100%, specificity of 97%, positive predictive value of 90%, and a negative predictive value of 100%.

Conclusion:

The different European approach in PEM using personalized FDG-dosage enables the comparability of FDG-metabolism in patients, resulting in a high diagnostic accuracy of PEM tests.

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Citation Format: Frank HH Müller, Hentschel Michael, Anton G Müller, Jamshid Farahati. PEM tests will have a high accuracy detecting breast cancer, if an individualized dosage of F-18-FDG is used [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-01-11.