bluuebunny/crossref_metadata_2025 huggingface dataset:
Loss of Conserved rRNA Modifications in the Peptidyl Transferase Center Leads to Diminished Protein Synthesis and Cell Growth in Budding Yeast
Authors: Leppik Margus , Pomerants Liisa , Põldes Anett , Mihkelson Piret , Remme Jaanus , Tamm Tiina
Published: May 2024

Ribosomal RNAs (rRNAs) are extensively modified during the transcription and subsequent maturation. Three types of modifications, 2′-O-methylation of ribose moiety, pseudouridylation, and base modifications, are introduced either by a snoRNA-driven mechanism or by stand-alone enzymes. Modified nucleotides are clustered at the functionally important sites, including peptidyl transferase center (PTC). Therefore, it has been hypothesised that the modified nucleotides play an important role in ensuring the functionality of the ribosome. In this study, we demonstrate that seven 25S rRNA modifications, including four evolutionarily conserved modifications, in the proximity of PTC can be simultaneously depleted without loss of cell viability. Yeast mutants lacking three snoRNA genes (snR34, snR52, and snR65) and/or expressing enzymatically inactive variants of spb1(D52A/E679K) and nop2(C424A/C478A) were constructed. The results show that rRNA modifications in PTC contribute collectively to efficient translation in eukaryotic cells. The deficiency of seven modified nucleotides in 25S rRNA resulted in reduced cell growth, cold sensitivity, decreased translation levels, and hyperaccurate translation, as indicated by the reduced missense and nonsense suppression. The modification m5C2870 is crucial in the absence of the other six modified nucleotides. Thus, the pattern of rRNA-modified nucleotides around the PTC is essential for optimal ribosomal translational activity and translational fidelity.
Proposal of Simplified Standardization of the Cell-Growth-Promoting Activity of Human Adipose Tissue Mesenchymal Stromal Cell Culture Supernatants
Authors: Enosawa Shin , Kobayashi Sho , Kobayashi Eiji
Published: May 2024

The conditioned medium (CM) obtained from mesenchymal stromal cell (MSC) culture has excellent cell growth-promoting activity and is used for cosmetics and healthcare products. Unlike pharmaceuticals, strict efficacy verification is not legally required for these products. However, their efficacy must be substantiated as commercial products. We attempted to simplify CM production and to standardize the evaluation of the growth-promoting activity of CM. CM was obtained through the culturing of two lines of commercially available human adipose tissue-derived MSCs using MEMα with or without 10% fetal bovine serum (FBS) for 24 h. Non-CM control media were produced by the same protocol without MSCs. Growth-promoting activities of the CM were estimated by [3H]-thymidine pulse. CM were subjected to molecular weight fractionation with ultrafiltration using 10 k-, 30 k-, 50 k-, and 100 k-membranes. The FBS-free CMs showed 1.34- to 1.85-fold increases and FBS-containing CMs showed 1.45- to 1.67-fold increases in proliferation-promoting activity compared with non-CM controls, regardless of the source of the cell. The thymidine incorporation levels were approximately three times higher in FBS-containing CMs. Aged cells also showed 1.67- to 2.48-fold increases in the activity due to FBS-containing CM, but not to FBS-free CM. The CM activities were sustained even after 1 year at 4 °C. Molecular weight fractionation showed that the activity was recovered in the fraction above 100 k. Clear and stable cell-growth-promoting activity was confirmed with CMs of commercially available adipose tissue MSCs. The activity was detected in the fraction over 100 k. We propose here the importance of standardizing the production and evaluation of CMs to indicate their specific action.
NR4A2 as a Novel Target Gene for Developmental and Epileptic Encephalopathy: A Systematic Review of Related Disorders and Therapeutic Strategies
Authors: Gabaldon-Albero Alba , Mayo Sonia , Martinez Francisco
Published: May 2024

The NR4A2 gene encodes an orphan transcription factor of the steroid–thyroid hormone–retinoid receptor superfamily. This review focuses on the clinical findings associated with the pathogenic variants so far reported, including three unreported cases. Also, its role in neurodegenerative diseases, such as Parkinson’s or Alzheimer’s disease, is examined, as well as a brief exploration on recent proposals to develop novel therapies for these neurological diseases based on small molecules that could modulate NR4A2 transcriptional activity. The main characteristic shared by all patients is mild to severe developmental delay/intellectual disability. Moderate to severe disorder of the expressive and receptive language is present in at least 42%, while neuro-psychiatric issues were reported in 53% of patients. Movement disorders, including dystonia, chorea or ataxia, are described in 37% patients, although probably underestimated because of its frequent onset in late adolescence–young adulthood. Finally, epilepsy was surprisingly present in 42% of patients, being drug-resistant in three of them. The age at onset varied widely, from five months to twenty-six years, as did the classification of epilepsy, which ranged from focal epilepsy to infantile spasms or Lennox–Gastaut syndrome. Accordingly, we propose that NR4A2 should be considered as a first-tier target gene for the genetic diagnosis of developmental and epileptic encephalopathy.
Surviving a Double-Edged Sword: Response of Horticultural Crops to Multiple Abiotic Stressors
Authors: Yan Wenjing , Sharif Rahat , Sohail Hamza , Zhu Yu , Chen Xuehao , Xu Xuewen
Published: May 2024

Climate change-induced weather events, such as extreme temperatures, prolonged drought spells, or flooding, pose an enormous risk to crop productivity. Studies on the implications of multiple stresses may vary from those on a single stress. Usually, these stresses coincide, amplifying the extent of collateral damage and contributing to significant financial losses. The breadth of investigations focusing on the response of horticultural crops to a single abiotic stress is immense. However, the tolerance mechanisms of horticultural crops to multiple abiotic stresses remain poorly understood. In this review, we described the most prevalent types of abiotic stresses that occur simultaneously and discussed them in in-depth detail regarding the physiological and molecular responses of horticultural crops. In particular, we discussed the transcriptional, posttranscriptional, and metabolic responses of horticultural crops to multiple abiotic stresses. Strategies to breed multi-stress-resilient lines have been presented. Our manuscript presents an interesting amount of proposed knowledge that could be valuable in generating resilient genotypes for multiple stressors.
Investigation of the Nitriding Effect on the Adhesion and Wear Behavior of CrN-, AlTiN-, and CrN/AlTiN-Coated X45CrMoV5-3-1 Tool Steel Formed Via Cathodic Arc Physical Vapor Deposition
Authors: Aktaş Çelik Gülşah , Fountas Konstantinos , Atapek Şaban Hakan , Polat Şeyda , Kamoutsi Eleni , Zervaki Anna D.
Published: May 2024

Monolayer (CrN, AlTiN) and bilayer (CrN/AlTiN) coatings are formed on the surface of conventional heat-treated and gas-nitrided X45CrMoV5-3-1 tool steel via Cathodic Arc Physical Vapor Deposition (CAPVD), and the adhesion characteristics and room- and high-temperature wear behavior of the coatings are compared with those of the un-nitrided ones. Scratch tests on the coatings show that the bilayer coating exhibits better adhesion behavior compared to monolayer ones, and the adhesion is further increased in all coatings due to the high load carrying capacity of the diffusion layer formed by the nitriding process. Dry friction tests performed at room temperature reveal that, among ceramic-based coatings, the coating system with a high adhesion has the lowest specific wear rate (0.06 × 10−6 mm3/N·m), and not only the surface hardness but also the nitriding process is important for reducing this rate. Studies on wear surfaces indicate that the bilayer coating structure has a tendency to remove the surface over a longer period of time. Hot wear tests performed at a temperature (450 °C) corresponding to aluminum extrusion conditions show that high friction coefficient values (>1) are reached due to aluminum transfer from the counterpart material to the surface and failure develops through droplet delamination. Adhesion and tribological tests indicate that the best performance among the systems studied belongs to the steel–CrN/AlTiN system and this performance can be further increased via the nitriding process.
A Review of Femtosecond Laser Processing of Silicon Carbide
Authors: Wang Quanjing , Zhang Ru , Chen Qingkui , Duan Ran
Published: May 2024

Silicon carbide (SiC) is a promising semiconductor material as well as a challenging material to machine, owing to its unique characteristics including high hardness, superior thermal conductivity, and chemical inertness. The ultrafast nature of femtosecond lasers enables precise and controlled material removal and modification, making them ideal for SiC processing. In this review, we aim to provide an overview of the process properties, progress, and applications by discussing the various methodologies involved in femtosecond laser processing of SiC. These methodologies encompass direct processing, composite processing, modification of the processing environment, beam shaping, etc. In addition, we have explored the myriad applications that arise from applying femtosecond laser processing to SiC. Furthermore, we highlight recent advancements, challenges, and future prospects in the field. This review provides as an important direction for exploring the progress of femtosecond laser micro/nano processing, in order to discuss the diversity of processes used for manufacturing SiC devices.
Palladium-Catalyzed Arylations towards 3,6-Diaryl-1,3a,6a-triazapentalenes and Evaluation of Their Fluorescence Properties
Authors: Wang Yingchun , Opsomer Tomas , de Jong Flip , Verhaeghe Davy , Mulier Maarten , Van Meervelt Luc , Van der Auweraer Mark , Dehaen Wim
Published: May 2024

Methyl 4-(1,3a,6a-triazapentalen-3-yl)benzoate (TAP1) shows interesting properties as a small molecule fluorophore. In the search for post-functionalization methods, palladium-catalyzed arylation reactions were demonstrated. Direct CH arylation reactions of TAP1 with various aryl halides resulted in 3,6-diaryltriazapentalenes TAP4, although mostly in poor yields. Bromination of TAP1 followed by Suzuki coupling, on the other hand, requires a more delicate procedure, but gave arylated products with the same regiochemistry (TAP4) in moderate to good yields. The structure of 6-phenyltriazapentalene TAP4a was confirmed by crystallographic analysis. In addition, the effect of the C6 arylation on the fluorescent properties of 3-aryl-1,3a,6a-triazapentalenes was studied in dichloromethane at room temperature and in 2-methyltetrahydrofuran at 77 K, while the photophysical properties of two saponified derivatives were measured in acetonitrile.
Pitahaya (Hylocereus ocamponis)-Peel and -Flesh Flour Obtained from Fruit Co-Products—Assessment of Chemical, Techno-Functional and In Vitro Antioxidant Properties
Authors: Reyes-García Verónica , Botella-Martínez Carmen , Juárez-Trujillo Naida , Muñoz-Tébar Nuria , Viuda-Martos Manuel
Published: May 2024

The aim of this work was to assess the chemical composition and physico-chemical, techno-functional, and in vitro antioxidant properties of flours obtained from the peel and flesh of pitahaya (Hylocereus ocamponis) to determine their potential for use as ingredients for food enrichment. The chemical composition, including total betalains, mineral content, and polyphenolic profile, was determined. The techno-functional properties (water holding, oil holding, and swelling capacities) were also evaluated. For the antioxidant capacity, four different methodologies, namely ferrous ion-chelating ability assay, ferric-reducing antioxidant power assay; 1,1-Diphenyl-2-picrylhydrazyl radical scavenging ability assay, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical assay, were used. Pitahaya-peel flour had higher values for protein (6.72 g/100 g), ash (11.63 g/100 g), and dietary fiber 56.56 g/100 g) than pitahaya-flesh flour, with values of 6.06, 3.63, and 8.22 g/100 g for protein, ash, and dietary fiber, respectively. In the same way, pitahaya peel showed a higher content of minerals, betalains, and polyphenolic compounds than pitahaya-flesh flour, with potassium (4.43 g/100 g), catechin (25.85 mg/g), quercetin-3-rhamnoside (11.66 mg/g) and myricetrin (12.10 mg/g) as principal compounds found in the peel. Again, pitahaya-peel flour showed better techno-functional and antioxidant properties than pitahaya-flesh flour. The results obtained suggest that the flours obtained from the peel and pulp of pitahaya (H. ocamponis) constitute a potential material to be utilized as an ingredient in the food industry due to the high content of bioactive compounds such as betalains, phenolic acids, and flavonoids, with notable antioxidant capacity.
Pulse Consumption and Health Outcomes: A Scoping Review
Authors: Zhao Naisi , Jiao Keyi , Chiu Yu-Hsiang , Wallace Taylor C.
Published: May 2024

Pulses—comprising the dry, edible seeds of leguminous plants—have long been lauded for their culinary flexibility and substantial nutritional advantages. This scoping review aimed to map the evidence on how pulses contribute to overall human health. Four electronic databases were searched for clinical and observational studies in English. We identified 30 articles (3 cross-sectional studies, 1 federated meta-analysis, 8 prospective cohort studies, 1 before-and-after study, and 17 randomized controlled trials) that met our inclusion criteria. Predominant among the pulses studied were lentils, chickpeas, common bean varieties (e.g., pinto, black, navy, red, kidney), black-eyed peas, cowpeas, and split peas. Consumption modalities varied; most studies examined mixed pulses, while five isolated individual types. In intervention studies, pulses were incorporated into diets by allotting a fixed pulse serving on top of a regular diet or by substituting red meat with pulses, offering a comparative analysis of dietary effects. The health outcomes evaluated were multifaceted, ranging from lipid profiles to blood pressure, cardiovascular disease risk and mortality, type 2 diabetes and glycemic control, metabolic syndrome indicators, inflammatory markers, oxidative stress biomarkers, and hormonal profiles. The most frequently assessed study outcomes included changes in low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, fasting blood sugar, hemoglobin A1c, waist circumference, and C-reactive protein or high-sensitivity C-reactive protein. This review should serve as a call to action for the scientific community to build upon the existing evidence, enriching our understanding of the nutritional and health-promoting attributes of pulses.
Development and Evaluation of a Novel Antibacterial Wound Dressing: A Powder Preparation Based on Cross-Linked Pullulan with Polyhexamethylene Biguanide for Hydrogel-Transition in Advanced Wound Management and Infection Control
Authors: Su Jiangtao , Yu Wantao , Guo Xiaoxia , Wang Chaofan , Wang Qianqiu , Chen Ban , Hu Yuchen , Dai Heshuang
Published: May 2024

As antibiotic resistance increasingly undermines traditional infection management strategies, there is a critical demand for innovative wound care solutions that address these emerging challenges. This study introduces a novel antibacterial wound dressing based on Cross-Linked Pullulan (Pul) and Polyhexamethylene Biguanide (PHMB) for enhanced wound management and infection control. The dressing’s adsorption rate reached 200% of its original weight within 30 min, exceeded 300% after 5 h, and exhibited significant non-Newtonian fluid properties. The dressings were able to release the loaded medication completely within 20 min; additionally, the dressing demonstrated significant antibacterial activity against a broad spectrum of bacteria. Significantly, the therapeutic effects of the Pul-PHMB/GP dressing were evaluated in a mouse model. Compared to untreated wounds, wounds treated with Pul-PHMB/GP exhibited a significant gelation process within 5 min post-treatment and showed a significant increase in wound healing rate within 12 days. This powder preparation overcomes the limitations associated with liquid and gel dressings, notably in storage and precise application, preventing the premature expansion or dissolution often caused by PHMB in high-humidity environments. The powder form can transform into a gel upon contact with wound exudate, ensuring accurate coverage of irregular wounds, such as those from burns or pressure sores, and offers excellent chemical and physical stability in a dry state, which facilitates storage and transport. This makes the dressing particularly suitable for emergency medical care and precision therapy, significantly improving the efficiency and adaptability of wound treatment and providing robust support for clinical treatments and emergency responses.
Rainfall Differences and Possible Causes of Similar-Track Tropical Cyclones Affected and Unaffected by Binary Tropical Cyclones (BTCs) in China
Authors: Wang Mingyang , Ren Fumin , Chen Guanghua , Lin Xiaohong
Published: May 2024

Binary tropical cyclones (BTCs) typically refer to the coexistence of two tropical cyclones (TCs) within a specific distance range, often resulting in disastrous rainstorms in coastal areas of China. However, the differences in rainfall and underlying causes between BTC-influenced typhoons and general typhoons remain unclear. In this article, the TC closer to the rainfall center in the BTC is referred to as the target typhoon (tTC), while the other is termed the accompanying typhoon (cmp_TC). This study compares and analyzes the rainfall differences and potential causes of tTCs and similar typhoons (sim_TC) with a comparable track but which are unaffected by BTCs from 1981 to 2020. The results show that: (1) On average, tTCs and cmp_TCs experience 18.79% heavier maximum daily rainfall compared to general TCs, with a significantly increased likelihood of rainfall ≥250 mm. (2) Given similar tracks, the average rainfall for tTCs (212.62 mm) is 30.2% heavier than that for sim_TCs (163.30 mm). (3) The analysis of potential impact factors on rainfall (translation speed, intensity, direction change) reveals that sim_TCs move at an average of 21.38 km/h, which is about 19.66% faster than the 17.87 km/h of tTCs, potentially accounting for the observed differences in rainfall. (4) Further investigation into the causes of west–east oriented BTC rainfall in the Northern Fujian (N_Fujian) region suggests that water vapor transport and slowing down of the translation speed are the possible mechanisms of BTC influence. Specifically, 80% of tTCs receive water vapor from the direction of their cmp_TC, and the steering flow for tTC is only 59.88% of that for sim_TC.
CMOS Compatible Hydrogen Sensor Using Platinum Gate and ALD–Aluminum Oxide
Authors: Elshaer Adham , Ecoffey Serge , Jaouad Abdelatif , Monfray Stephane , Drouin Dominique
Published: May 2024

In this study, a p-Si/ALD-Al2O3/Ti/Pt MOS (metal oxide semiconductor) device has been fabricated and used as a hydrogen sensor. The use of such a stack enables a reliable, industry-compatible CMOS fabrication process. ALD-Al2O3 has been chosen as it can be integrated into the back end of the line (BEOL) or in CMOS, post processing. The device response and recovery are demonstrated with good correlation between the capacitance variation and the hydrogen concentration. Detection down to 20 ppm at 140 °C was obtained and a response time of 56 s for 500 ppm was recorded.
Filtering Empty Video Frames for Efficient Real-Time Object Detection
Authors: Liu Yu , Kang Kyoung-Don
Published: May 2024

Deep learning models have significantly improved object detection, which is essential for visual sensing. However, their increasing complexity results in higher latency and resource consumption, making real-time object detection challenging. In order to address the challenge, we propose a new lightweight filtering method called L-filter to predict empty video frames that include no object of interest (e.g., vehicles) with high accuracy via hybrid time series analysis. L-filter drops those frames deemed empty and conducts object detection for nonempty frames only, significantly enhancing the frame processing rate and scalability of real-time object detection. Our evaluation demonstrates that L-filter improves the frame processing rate by 31–47% for a single traffic video stream compared to three standalone state-of-the-art object detection models without L-filter. Additionally, L-filter significantly enhances scalability; it can process up to six concurrent video streams in one commodity GPU, supporting over 57 fps per stream, by working alongside the fastest object detection model among the three models.
Quality and customer loyalty in the port services of Manzanillo
Authors: Reyes-Real Oscar Bernardo , Osegueda-Rodríguez Rubí , Amezcua-Vivaz José de Jesús
Published: May 2024

The customs industry, particularly within the Mexican context, plays a significant role both domestically and internationally, owing to its contribution to the global economy. With the expansion and standardization of customs clearance services, there has emerged a necessity for providers of these services to seek customer loyalty. Grounded in the principles of quality, the study examines the elements of the SERVQUAL model: tangibles, reliability, responsiveness, assurance, and empathy.

Goals:The aim of the study was to extend the SERVQUAL model by incorporating customer attitude as an additional component within the three primary dimensions for measuring service quality.

Methodology: A survey was employed to gather data from 100 customs brokerage firms through simple random sampling. Given the utilization of structural equation modeling (SEM) methodology to assess the theoretical model, Partial Least Squares (PLS) analysis technique was applied using Smart PLS 3.3.0 software. The findings indicated that the extended model had a significant impact on both customer satisfaction and loyalty within the customs facilities of Manzanillo, Colima. The coefficients of determination were 61.5% for customer satisfaction and 54% for customer loyalty, with a root mean square error of approximation (SRMR) of 0.065, confirming the model's predictive validity.

Contributions: Customs facilities should focus their strategies on addressing issues that may be impacting service quality, particularly concerning sensitivity, empathy, and reliability factors, as these have a moderate level of influence on quality determination, according to customs agencies' perceptions. Regarding the inherent limitations of online surveys and their application in specialized groups, it is crucial to expand the research to include other clients of the customs facility.
ASPECTS REGARDING THE USE OF SOLAR ENERGY IN SMALL AND MEDIUM FARMS
Authors: CRISTEA Mario , VLĂDUȚ Nicolae-Valentin , MOICEANU Georgiana
Published: May 2024

Considering that every day the sun generates more energy than the planet needs for daily consumption, harnessing solar energy represents one of the future solutions for clean, sustainable energy, obviously with the technological limitations related to the ability to transform this energy into electricity. The paper presents a functional model of equipment that allows the capture of solar energy using special panels, which can rotate both horizontally and vertically according to the sun, so that the incidence of rays with the radiating surface of the panels is maximum and the yields obtained at different angles of inclination in the vertical plane at 60, respectively in the horizontal plane at 0o.
Reaction and denial propaganda on social media
Authors: Hernández-Santaolalla Víctor , Rubio-Hernández María del Mar , Fernández Gómez Jorge David , Oliveira Julieti Sussi de
Published: May 2024

Introduction: For political organizations, social media, far from being a space for dialogue with citizens, have become another tool for unidirectional communication. Thus, this paper aims to deepen the propagandistic use of YouTube by political parties, focusing the case study on Andalusia, the Spanish region with the largest population and the first where the far-right party Vox achieved influential parliamentary representation. Methodology: Specifically, a content analysis was applied to 999 videos published throughout 2020 by political parties with representation in the Andalusian Parliament, considering variables such as the presence of the party symbols, the type of propaganda used and the reference to a rival political party. Results: Considering the foregoing, the results are discussed in terms of de-ideologization, populism, and the reduction of programmatic ideas. Conclusions: We find differences in the type of propaganda used (with emphasis on reaction and denial propaganda), pointing to a significant inability of political parties to propose alternatives, which is related to the rise of populism and the pseudo-abandonment of ideology.
Pengaruh Pemberian Multivitamin Fatigon Spirit® Terhadap VO2 Maks Pada Mahasiswa JPOK
Authors: Huldani Huldani
Published: May 2024

Telah dilakukan penelitian untuk mengetahui keefektifan pemberian Multivitamin Fatigon Spirit® sebelum latihan. Multivitamin Fatigon Spirit® adalah beberapa multivitamin yang beredar di masyarakat dan diklaim dapat meningkatkan ketahanan kerja dan mengurangi kelelahan. Penilaian kapasitas oksigen maksimal sangat penting untuk memonitor kemampuan daya tahan kardiovaskuler, pernafasan dan otot seseorang sehingga dapat menjadi acuan dalam mempertahankan dan meningkatkan kesegaran jasmaninya. Teknik pengambilan sampel dengan menggunakan non probability purposive sampling dengan besar sampel berjumlah 35 orang laki-laki mahasiswa JPOK UNLAM Banjarbaru yang mempunyai rentang usia 19-23 tahun. Bahan penelitian menggunakan Multivitamin Fatigon Spirit® yang dikonsumsi 1 jam sebelum dilakukan latihan Multistage fitness test. Penelitian bersifat kwasi pre test-post test design dengan metode single blind. Data yang didapatkan akan dianalisis secara statistik dengan komputerisasi menggunakan program Statistical package for Social Science (SPSS) dengan metode statistik Uji T berpasangan dengan dilakukan uji normalitas sebelumnya. Hasil statistik tersebut menujukkan perbedaan yang signifikan antara sebelum dan sesudah pemberian Multivitamin Fatigon Spirit® atau dengan kata lain pemberian Multivitamin Fatigon Spirit® efektif dalam meningkatkan kapasitas oksigen maksimal.
Pengaruh Pemberian Quercetin Terhadap Kematian Sel Endotel Aorta Tikus Wistar Yang Diberi Diet Atherogenik
Authors: Budiman Frenky Arif
Published: May 2024

Atherosklerosis merupakan suatu penyakit degeneratif. Proses Atherosklerosis terjadi melalui beberapa tahap. Kejadian awal yang berperan pada proses atherosklerosis adalah kerusakan atau disfungsi endotel karena kadar lemak LDL. LDL Lipoprotein) adalah kolesterol “jahat” yang potensial menyumbat pembuluh darah. Akan tetapi, hal tersebut dapat dicegah dengan pemberian antioksidan. Oleh karena itu, perlu adanya altermatif pengobatan yang bersifat preventif yang bahannya berasal dari buah-buahan. Quersetin adalah salah satu zat aktif kelas flavonoid yang secara biologis amat kuat. Antioksidan ini dapat mencegah kerusakan sel sel endotel atau jaringan pembuluh darah. Pada saat bersamaan, antioksidan akan meningkatkan koesterol “baik” (High Density Lipoprotein / HDL) yang bermanfaat untuk mencegah penyakit jantung dan pembuluh darah. Penelitian ini bertujuan mengetahui peranan quercetin sebagai antioksidan dalam mencegah penurunan jumlah sel endotel aorta tikus yang diberi diet aterogenik. Jenis penelitian ini menggunakan experimental laboratorik pada hewan coba tikus dengan menggunakan desain penelitian Control Group Post Test Design. Variabel penelitian ini adalah jumlah sel endotel aorta. Hasil uji statistik One Way Anova menunjukkan bahwa terdapat perubahan jumlah sel endotel aorta tiap taraf perlakuan yang signifikan. Kesimpulan dari penelitian ini adalah pemberian quercetin dengan dosis 56 mg paling potensial dalam pencegahan penurunan jumlah sel endotel aorta tikus.
Hubungan Antara Gaya Kepemimpinan Kepala Rungan Terhadap Kepatuhan Perawat Memakai APD Sesuai Prosedur Pada Pemeriksaan TTV Di Ruang IGD Rumah Sakit
Authors: Nurhanifah Dewi , Firdaus Muhammad Rizal
Published: May 2024

Gaya kepemimpinan didefinisikan suatu pola perilaku yang ditampilkan sebagai pemimpin ketika mencoba mempengaruhi orang lain. Kepatuhan perawat adalah perilaku perawat sebagai seorang yang professional terhadap suatu anjuran, prosedur atau peraturan yang harus dilakukan atau di taati. Adapun praktik memakai APD sesuai prosedur untuk mengendalikan infeksi dalam lingkungan perawatan akan selalu menjadi prioritas bagi para petugas kesehatan. Hubungan Antara Gaya Kepemimpinan Kepala Ruangan Terhadap Kepatuhan Perawat Memakai APD Sesuai Prosedur Pada Pemeriksaan TTV di Ruang IGD Rumah SakitKorelasi dengan rancangan cross sectional. Populasi berjumlah 31 orang perawat IGD Rumah Sakit. Teknik sampling yang digunakan adalah Total sampling. Metode pengumpulan data menggunakan kuesioner dan observasi. Data di analisis dengan univariat, bivariat dengan uji chi square dengan tingkat kemaknaan α= 0,05. Gaya kepemimpinan kepala ruangan IGD menerapkan yang demokratis, sedangkan kepatuhan perawat memakai APD Sesuai Prosedur Pada Pemeriksaan TTV yaitu patuh 68%. Hasil analisis uji Chi-Square p=0,029 <0,05 yang artinya Ho ditolak.
Perbandingan Kadar Interleukin-6 Dan Jumlah Limfosit Setelah Latihan Aerobik Ringan Dan Sedang Pada Remaja
Authors: Harun Lukman
Published: May 2024

Latihan fisik secara teratur dapat meningkatkan sistem kekebalan tubuh, olahraga dapat menyebabkan perubahan fisiologis yang cukup besar dalam sistem kekebalan tubuh, Latihan fisik secara teratur dapat meningkatkan kadar Interleukin-6 dan Jumlah Limfosit sebagai pertahanan sitokin dan adaptive dalam kekebalan tubuh. Penelitian ini bertujuan untuk mengetahui perbedaan kadar interleukin-6 dan jumlah limfosit terhadap latihan aerobik ringan dan sedang, Pengambilan sampel menggunakan teknik uji hipoteesis kelompok independen two tail dengan 9 Orang menurut kriteria inklusi.Penelitian ini menggunakan metode Quasi experiment design dengan rancangan penelitian posttest with Control Group. Hasil uji perbandingan kadar interleuin-6 Uji Kruskal-Wallis digunakan karena distribusi datatidak  Normal. Menunjukan bahwa p=0,031. Hal ini berarti bahwa rerata kadar IL-6 pada ketiga kelompok berbeda secara bermakna (p < 0,05). Hasil uji jumlah Limfosit Menunjukan bahwa hasil analisis dengan uji Analysis of Variance (Anova)  menunjukan bahwa nilai p=0,001. Hal ini bererti bahwa rerata jumlah limfosit pada ketiga kelompok berbeda secara bermakna (p<0,05).
Faktor – Faktor Yang Mempengaruhi Keputusan Ibu Dalam Memilih Tempat Persalinan Di BPM
Authors: Rusdiyanti Ivong
Published: May 2024

Capaian keberhasilan upaya kesehatan pada ibu, salah satunya terlihat dari indikator Angka Kematian Ibu (AKI). Upaya untuk menekan resiko AKI antara lain menganjurkan kepada masyarakat agar persalinan yang aman ditolong oleh tenaga kesehatan terlatih dan dilakukan di fasilitas kesehatan, bidan adalah tenaga kesehatan yang salah satunya memberikan pelayanan kesehatan kepada ibu dan anak secara langsung. Bidan memiliki kedudukan memberikan kemudahan dalam pelayanan masa persalinan, promosi dan konsultasi kesehatan untuk ibu dan anak, serta melakukan deteksi dini terhadap kasus rujukan khususny di pedesaan. Salah satu sarana pelayanan kesehatan untuk ibu dan anak adalah BPM (Bidan Praktek Mandiri). Menganalisis faktor – faktor yang mempengaruhi keputusan ibu hamil dalam memilih tempat persalinan Di Bidan Praktek Mandiri Bidan Jaleha. Penelitian dilakukan dengan survey analitik dan pendekatan cross sectional, yang dilakukan pada bulan Oktober  –  Desember 2017. Jumlah sampel adalah 30 responden, teknik yang digunakan adalah total sampling. Data yang dikumpulkan ini menggunakan data primer dengan kuesioner dan data sekunder. Uji chi-square digunakan ntuk analisis data. Hasil analisa data menunjukkan bahwa faktor pekerjaan dan jumlah anak mempunyai korelasi dengan pemilihan tempat persalinan di BPM, sedangkan pendidikan, pendapatan, dan jarak tidak mempunyai korelasi dengan pemilihan tempat persalinan di BPM. Pendidikan, pekerjaan, pendapatan, jumlah anak, dan jarak secara simultan hanya mempengaruhi sebesar 37,1 % terhadap pemilihan tempat persalinan di BPM dan jumlah anak menjadi faktor dominan yang mempengaruhi.
Hubungan Ketidaksesuaian Tinggi Kursi Kerja Terhadap Keluhan Back Pain Pada Penjahit Pakaian Di Pasar Bauntung Martapura
Authors: Huldani Huldani
Published: May 2024

Prinsip-prinsip ergonomi belum banyak diterapkan pada sektor kerja informal, salah satunya penjahit pakaian. Ketidaksesuaian ukuran alat kerja dan antropometri penjahit, seperti penggunaan kursi kerja terlalu tinggi atau terlalu rendah berisiko menyebabkan terjadinya keluhan pada penjahit terutama pada komponen tulang belakang (back pain). Untuk mengetahui hubungan ketidaksesuaian tinggi kursi kerja terhadap keluhan back pain pada penjahit pakaian, telah dilakukan penelitian bersifat observasional analitik dengan pendekatan cross-sectional. Sampel penelitian berjumlah 30 orang yang diambil dengan teknik Quota Sampling. Penelitian dilakukan di Pasar Bauntung Martapura pada bulan Maret-November 2011. Pengambilan data dilakukan dengan pengukuran tinggi kursi kerja dan tinggi lipat lutut serta wawancara. Hasil penelitian didapatkan 23 responden (77%) menggunakan tinggi kursi kerja yang tidak sesuai dan 13 responden (43%) mengalami keluhan back pain. Analisis chi-square dengan derajat kepercayaan 95% didapatkan p=0,010 antara ketidaksesuaian tinggi kursi kerja terhadap keluhan back pain. Dapat disimpulkan bahwa terdapat hubungan antara ketidaksesuaian tinggi kursi kerja terhadap keluhan back pain pada penjahit pakaian di Pasar Bauntung Martapura.
Efek Suhu Kalsinasi Tulang Ikan Cakalang (Katsuwonus pelamis L.) Pada Aktivitas Fotokatalitik Komposit Ag3PO4-Hidroksiapatit
Authors: Kambey Aprilia , Wuntu Audy Denny , Suryanto Edi
Published: May 2024

ABSTRACT
Hydroxyapatite could be treated with silver nitrate to produce silver phosphate (Ag3PO4), which is a semiconductor material having ability to degrade synthetic dyes. This research aimed to determine the effect of skipjack tuna fish bone calcination temperature on the characteristics of Ag-modified fish bone products and their ability to degrade the synthetic dye rhodamine B (RB). Skipjack tuna bones were taken from a smoked skipjack fish market in Tanawangko, North Sulawesi. The research was initiated by synthesizing a composite with the main component hydroxyapatite from skipjack tuna (Katsuwonus pelamis L.) bones, which produced Ag3PO4 which was then used to degrade the synthetic dye RB in aqueous solution. The hydroxyapatite and composite were characterized using X-Ray Diffraction (XRD), Scanning Electron Microscopy - Energy Dispersive X-Ray (SEM-EDX), and Fourier-Transform Infrared Spectroscopy (FTIR) techniques. These characterizations confirmed the formation of Ag3PO4/HAp composite. Analysis of RB photodegradation activity using the composites showed that the best results of 76% RB degradation were obtained using 100 mg composite made from calcination temperature of 600 oC under 2 x 100 Watts incandescent lamp for 120 minutes.
Keywords: Fishbones; Ag3PO4; Hydroxyapatite; Photodegradation, Rhodamine B
 
ABSTRAK
Hidroksiapatit dapat diperlakukan dengan perak nitrat (AgNO3) untuk menghasilkan perak fosfat (Ag3PO4) yang merupakan material semikoduktor dengan kemampuan mendegradasi pewarna sintetik. Penelitian ini bertujuan untuk menentukan pengaruh suhu kalsinasi tulang ikan cakalang pada karakter produk tulang ikan termodifikasi Ag dan kemampuannya mendegradasi pewarna sintetik rodamin B (RB). Tulang ikan cakalang diambil dari pasar ikan cakalang asap di Tanawangko, Sulawesi Utara. Penelitian ini diimulai dengan mensintesis komposit dengan komponen utama hidroksiapatit dari tulang ikan cakalang (Katsuwonus pelamis L.) yang menghasilkan Ag3PO4 dan kemudian digunakan untuk mendegradasi pewarna sintetik RB dalam larutan dengan pelarut air. Hidroksiapatit dan komposit yang dihasilkan dikarakterisasi menggunakan teknik-teknik X-Ray Diffraction (XRD), Scanning Electron Microscopy - Energy Dispersive X-Ray (SEM-EDX), dan Fourier-Transform Infrared Spectroscopy (FTIR). Hasil karakterisasi menunjukkan bahwa telah terbentuk komposit Ag3PO4/HAp. Analisis aktivitas fotodegradasi RB menggunakan komposit tersebut menunjukkan bahwa kemampuan fotodegradasi terbaik adalah menggunakan 100 mg komposit dari tulang yang dikalsinasi pada suhu 600 oC di bawah radiasi sumber sinar tampak 2 x 100 watt selama 120 menit yang mampu mendegradasi 76% RB.
Kata Kunci: Tulang Ikan; Ag3PO4; Hidroksiapatit; Fotodegradasi; Rodamin B.
Job Satisfaction and Turnover Intention: The Moderation Role of Financial Compensation
Authors: Widyanata Jason Aji , Dwiatmadja Christantius
Published: May 2024

In managing Human Resources in a company, a leader must be able to handle the phenomenon of turnover intention. Turnover intention is a problem that arises in an organization involving the desire to leave employees. The turnover intention that occurs indicates low employee loyalty and a weak managerial system in the company. This research aims to examine the influence of job satisfaction variables on the turnover intention phenomenon and examine the role of financial compensation variables in moderating the influence of job satisfaction variables on the turnover intention phenomenon. The type of research used in this research is explanatory research. Sampling in this research was carried out using a purposive sampling technique or non-random sampling technique. The sample in this study involved 90 employees at PT. HM Sampoerna Semarang, all of which met the criteria to be used as samples. The data source in this research is primary data in the form of a questionnaire. The type of data in this research is cross section. In the research, it was found that the job satisfaction of each employee is relatively high, one of the factors that triggers turnover intention in this company is job satisfaction. The research results show that there is an influence between job satisfaction variables on turnover intention, and financial compensation cannot be a moderating variable or a supporting factor in the influence of job satisfaction on turnover intention at PT. HM Sampoerna Semarang.
Analysis of Factors Affecting Accountability of Village Fund Management
Authors: Sari Tri Ratna , Rohman Abdul
Published: May 2024

The responsibility of the village government is to enforce accountability to the community. If there are irregularities in the management of village funds, the community's trust in the village government could decrease. The aim of this research is to examine the impact of various factors that influence the accountability of village fund management. The population in this study was from all villages in the districts of Skanto , Arso , Arso Barat, and Mannem. The sampling process uses purposive sampling, namely selecting village officials involved in managing village funds. This group consists of the village head, secretary and treasurer. Primary data collection was carried out through distributing questionnaires which were given directly to respondents. Multiple linear regression is a statistical tool used for data analysis. Next, the data is processed using SPSS 26.0 software. Based on research, the effectiveness of village officials and internal control systems is known to have a positive impact on the accountability of village fund management. In contrast, leadership and integrity systems do not appear to have a significant influence.
The Influence of Offering Discounts through Social Media and Service Quality on Customer Loyalty in Laundry Services (A Case Study of KEN'Z Wash House, Tangerang)
Authors: Susilowati Maesaroh Tri , Gumilar Aris , Yuliyzar Ismayudin
Published: May 2024

Laundry in the present era is concurrent with the increasing competition in similar businesses. In terms of advertising and service quality, customers have various options for different laundry services. Consistent marketing and high-quality services will result in satisfied customers. Customers will be more satisfied when a business meets or exceeds their needs. This largely depends on how well the staff members perform their tasks. Therefore, KEN'Z Wash House emphasizes greatly on evaluating the effectiveness of services to customers, determined by customer feedback. By providing surveys for customers to fill out, KEN'Z Wash House hopes to measure the level of customer loyalty. Survey questions have a strong correlation with promotion and the quality of services provided from the perspective of perceived customer loyalty. Findings from these surveys will be analyzed to determine the extent of the impact of price reductions on social media and consistently high-quality services. By understanding how well KEN'Z Wash House services relate to customer loyalty, the company can gain deeper insights into its customers' opinions regarding discounts offered through social media and the quality of services provided by its staff. This will enable the company to develop strategies that effectively enhance future performance and win back loyal customers.
The Influence of Transformational Leadership and Work Culture on Work Commitment and Its Implications on the Performance of Village Fund Managers
Authors: Mogi Agustina , Priadana Sidik , Manik Ester
Published: May 2024

This research examines the influence of transformational leadership and work culture on work commitment and its implications for the performance of village fund managers on Flores Island, East Nusa Tenggara. The research method used is quantitative research with an explanatory survey approach. Data was collected through interviews, observation, and questionnaires with a Likert scale. Respondents are village fund managers from 6 districts on Flores Island. Hypothesis testing was done using Structural Equation Modeling (SEM) with SmartPLS 3.00 software. The research results show that transformational leadership and work culture significantly influence the work commitment and performance of village fund managers. Strong transformational leadership, characterized by collaboration, honesty, and trust, encourages increased work commitment and performance of village fund managers. Meanwhile, a positive work culture based on integrity, honesty, and accountability contributes to work commitment and performance. High work commitment also positively impacts individual and group performance, increasing motivation, job satisfaction, and the ability to face challenges. Finally, improving the performance of village fund managers on Flores Island requires the development of transformational solid leadership, the formation of a positive work culture based on the values of integrity and accountability, and increasing the work commitment of individual village fund managers. It is hoped that the results of this research can improve the effectiveness of village fund management and services to the community.
Analysis of The Determinants on Technology Share Prices Listed on the Indonesian Stock Exchange in the 2018-2022 period
Authors: Elisa Vivi , Purwanto Setiyo
Published: May 2024

This study aims to examine the effect of The Fed, Inflation and Total Cash Flow on stock prices in the technology sector listed on the Indonesia Stock Exchange for the period 2018-2022. The type of data used in this study is panel data using quantitative methods. The research sample involved six technology companies. Data is collected using company financial reports and macroeconomic data from official sources. The results showed that the Fed and inflation have a negative influence on stock prices. Meanwhile, total cash flow has a positive and significant effect on stock prices.
The Influence of Endorser Credibility, Brand Image, and Perceived Value on Customer Satisfaction Mediated by Brand Trust (Study of Jafra Consumers in Jakarta
Authors: Nurcahya Raditia , Bastaman Aam
Published: May 2024

This study aimed to determine the effects of Endorser Credibility, Brand Image, and Perceived Value on Customer Satisfaction among Jafra consumers in South Jakarta, mediated by Brand Trust, Brand Image, and Perceived Value obtained through distributing questionnaires. The research population consisted of Jafra consumers in South Jakarta, with a sample of 100 people selected using purposive sampling. Data were analyzed using PLS-based SEM. The results indicated that the variables of Endorser Credibility, Brand Image, and Perceived Value had a significant effect on Brand Trust. Furthermore, the results demonstrated that Endorser Credibility, Perceived Value, and Brand Trust significantly influenced Customer Satisfaction. Additionally, it was found that Brand Trust mediated the relationship between Brand Image and Customer Satisfaction, as well as between Perceived Value and Customer Satisfaction.
The Effect Of Customer Satisfaction And Trust On Customer Loyalty In The Shopee Marketplace
Authors: Suardhita Nyoman , Martiwi Rini , Elyana Instianti , Rahman Aan
Published: May 2024

This research aims to test the influence of trust and customer satisfaction on customer loyalty, test the influence of trust on customer loyalty and test the influence of customer satisfaction on customer loyalty. This research uses a quantitative descriptive method by distributing questionnaires via Google Form with purposive sampling, namely Shopee users as an online shopping platform for consumers in Depok. A purposive sampling method of 150 respondents was used for the sampling. SPSS 26 was used to calculate the multiple linear regression variable test to analyze the research data results. The research results show that customer satisfaction and trust are important in forming customer loyalty to Shopee. Factors such as ease of use, wide product selection, responsive customer service, and security of online transactions influence customer satisfaction levels. In addition, customer trust in the security of online transactions and product quality also plays a key role in building long-term relationships between customers and e-commerce platforms. The R square value of 0.725 indicates that most of the variation in customer loyalty levels can be explained by customer satisfaction and trust in Shopee in Depok. At the same time, the rest is influenced by other factors, such as quality. Product and brand preferences.
Proposed Knowledge Management System in Farms to Increase Productivity
Authors: Monica Resta Lestari  , Mulyana Asep , Yunizar Yunizar
Published: May 2024

Animals developing is a sub-area of cultivation that has a lot of room for improvement as a sub-cultivating from now into the foreseeable future. The public's essential for creature things will manufacture dependably, as animals is one of the providers of proteins, energy, enhancements and crucial minerals, and meanwhile open respect for the supporting necessities to work on the singular satisfaction is making. The legitimization behind the continuous review is to perceive the on a very basic level fundamental credits and issues of sheep ranches working in the city of Bangko and to propose two or three arrangements with any outcomes in regards to these issues. The stream study's outcomes are supposed to give data to future examination and add to the ongoing extension of value and efficiency. A profound strategy with a setting focused assessment approach is proposed for this evaluation. The emotional strategy was picked in light of the fact that it is the most effective way to check out at the issues and gives a profound comprehension of the issues with Bangko Estate's business. The proprietor of Bangko Farm proposed that, to make arrangements for the organization's extension, we lay out a business methodology from all points, especially in the execution of leader data, to build effectiveness and find all issues immediately. Before expanding the business, the owner's primary focus is on creating a knowledge management-based strategy for human resources development.