bluuebunny/crossref_metadata_2025 huggingface dataset:
WITHDRAWN: IoT-based Machinery Failure Predictive Solution using Big Data Analysis on the MIMII Dataset
Authors: Talmoudi Sana , Kanada Tetsuya , Hirata Yasuhisa
Published: July 2020

One of the main focuses of smart industry is machinery failure predictive solutions. To achieve this, IoT-based solutions have been widely deployed. However, data processing and decision making remain challenging. The absence of enough knowledge has been the primarily limitation of statistical methods and supervised learning methods. Therefore, unsupervised learning methods are gaining more popularity but still have limits to cover effectively the pre-signs of failures due to the complexity of training process and results visualization. Previously, we proposed a novel Big Data Analysis method on audio/vibration data to cover effectively the pre-signs of failures through data visualization without complex learning or processing. We validated our proposal on a demo system. In the present work, we are using part of the MIMII dataset to test our proposed analysis method on a real-world-like data and verify the validity of our proposal on a more complex system. We are showing that we can detect abnormal machine behaviors and predict failures without prior training or knowledge of the target monitored machine.
Study on the Protective Effect and the Metabolomics Features of Rutaecarpine on Ethanol-induced Acute Gastric Ulcer
Authors: ren sichen , Wei Ying , Niu Ming , Wang Ruilin , Wei Shizhang , Wen Jianxia , Wang Dan , Yang Tao , Chen Xing , Wu Shihua , Tong Yuling , Jing Manyi , Li Haotian , Wang Min , Zhao Yanling
Published: July 2020

As a prevalent digestive disease, Gastric ulcer (GU) has a high incidence and is seriously harmful to human health. It is an urgent need to finding a natural drug with a gastroprotective effect. Rutaecarpine (RUT) is an alkaloid isolated from Evodia rutaecarpa Bentham (Rutaceae). This plant is a traditional Chinese medicine that has been treating gastrointestinal diseases for a long time. The present study aimed to investigate the effects of RUT on ethanol-induced acute GU in mice. After intragastrical administration of RUT for 3 consecutive days, acute GU were induced in the mice by ethanol treatment for 1.5 h. The expression levels of SOD, CAT, NO, ET-1 in serum and EGF, TNF-α, IL-1β, IL-6 in gastric tissues were measured by kits. In addition, hematoxylin and eosin (H&E) staining of gastric mucosa for pathological changes was evaluated. The serum metabolomics method based on ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was used to explore the potential mechanism. A total of 7 potential metabolites involved in 9 metabolic pathways were identified. This study helps us to further understand the pathogenesis of GU and provide a potential natural anti-ulcer drug for clinic.
Cytoplasm Protein GFAP Magnetic Beads Construction and Application as Cell Separation Target for Brain Tumors
Authors: Zhao Yang , Jiang Feng , Wang Qinhua , Wang Baocheng , Han Yipeng , Yang Jian , Wang Jiajia , Wang Kai , Ao Junping , Guo Xunxiang , Liang Xiaofei , Ma Jie
Published: July 2020

BACKGROUND: It is very important to develop a highly efficient cerebrospinal fluid (CSF) detection system with diagnosis and prediction function, for which the detection of circulating tumor cells (CTCs) in CSF is a good choice. In contrast to the past use of epithelial EpCAM as CTCs separation target, a cytoplasm protein of GFAP antibody was first selected to construct highly-sensitive immunomagnetic liposome beads (IMLs). The validation and efficiency of this system in capturing CTCs for brain tumors were measured both in vitro and in vivo. The associations between the numbers of CTCs in patients with their clinical characteristics were further analyzed. RESULTS: Our data show that CTCs can be successfully isolated from CSF and blood samples from 32 children with brain tumors. The numbers of CTCs in CSF were significantly higher than those in blood. The level of CTCs in CSF was related to the type and location of the tumor rather than its stage. The higher the CTCs number is, the more possibly the patient will suffer from poor prognosis. Genetic testing in GFAP CTC-DNA by sanger sequencing, q-PCR and NGS methods indicated that the isolated CTCs (GFAP+/EGFR+) are the related tumor cell. For example, the high expression of NPR3 gene in CSF CTCs was consistent with that of tumor tissue.CONCLUSIONS: The results indicated that GFAP-IML CTCs isolation system, combined with an EGFR immunofluorescence assay of antitumor marker, can serve as a brand-new method for the identification of CTCs for brain tumors. Via lumbar puncture, a minimally invasive procedure, this technique may play a significant role in the clinical diagnosis and drug evaluation of brain tumors.
Clinical And Laboratory Characteristics And Growth Outcomes Of Children With Growing Pains
Authors: Liao Chung-Yuan , Lee Jyh-Hong , Wang Li-Chieh , Wu Kuan-Wen , Lin Yu-Tsan , Yang Yao-Hsu , Chiang Bor-Luen , Yu Hsin-Hui
Published: July 2020

Background: Growing pains is a benign, non-inflammatory pain syndrome of childhood, characterized by bilateral recurrent leg pain. Studies regarding the clinical and laboratory proﬁle of growing pains are limited, especially in East Asia. The aim of this study was to analyze the clinical features, laboratory ﬁndings, and follow-up of children with growing pains.Methods: Patients under 18 years of age with growing pains in National Taiwan University Children’s Hospital between April 2006 and April 2019 were enrolled. Clinical features, laboratory data and medication records were analyzed. Changes of body height and weight before and after the symptoms were assessed by the paired samples t-test.Results: After excluding 31 children with musculoskeletal diseases, 276 patients with a final diagnosis of growing pains were included, comprising 152 boys (55%) and 124 girls (45%). The mean age was 4.9 ± 2.7 years. Bilateral and lower limbs pain were present in 232 (84%) and all cases, respectively. There were 6 out of 16 patients (38%) with elevated alkaline phosphatase, and 3 out of 50 (6%) with positive antinuclear antibodies in low titers. There were no significant changes in body height and weight percentiles or z-scores at 0.5, 1, and 2 years after diagnosis, compared with baseline values. Symptomatic treatments were used in 33% of patients.Conclusions: Growing pains is a common benign leg pain syndrome in children. Alkaline phosphatase elevation is commonly detected. It is not associated with rapid changes of body height and weight within 2 years of experiencing growing pains.
Oral Antioxidants Mitigate Levels of Malonedialdehyde and Protein Carbonyl and Improve Semen Parameters in Men with Oligoasthenozoospermia
Authors: Zhaku Vegim , Beadini Sheqibe , Beadini Nexhbedin , Amzai Gazmend
Published: July 2020

Raising awareness about treating options in North Macedonia, while sperm parameters are decreasing because of increased oxidative stress, in a terrain like this, represents a big challenge. All the patients that fulfilled the required criteria, 37 were enrolled in the study signing a document that explains nature of the study. The first semen sample was collected with at least three days of abstinence. From the sample 0.5 ml was used for standard semen analysis, 1.2 ml was used to evaluate the levels of malonedialdehyde (MDA) and protein carbonyl (PC). The last sample was collected after 6 months. Mean, Standard Deviation, the Pearson Correlation and an independent student t-test were used for statistical analyses. Concentration and motility were significantly increased after 6 months of treatment (p<0.001).The level of MDA shows significantly lower values after six months of therapy with antioxidants (p<0.001).Whereas another marker which is denoted by PC was also lower after the treatment, but was not statistically significant (p=0.0554). There is, however, lack of agreement, because improvement is not consistent and there is wide variation in the treatment regimens, on the dose and duration of treatment and whether mono or combined oral antioxidants should be administered. Always keep on mind that, antioxidants are not free from potential side effects “antioxidant paradox”.
Effects of Intravenous Lidocaine on Alfentanil Consumption During Procedural Sedation for Colonoscopy in Patients With Inflammatory Bowel Disease: a Randomized Controlled Trial
Authors: Aalbers Twan , Heuvel Sandra A.S. van den , Bronkhorst Ewald M. , Esch Aura A.J. van , Scheffer Gert Jan , Vaneker Michiel
Published: July 2020

Background: Procedural sedation and analgesia (PSA) is used during colonoscopy to facilitate the procedure and relieve patient’s discomfort. The foremost risk of PSA is respiratory depression. Lidocaine could be a promising additional analgesic in IBD patients to minimise side effects of PSA.Our primary objective was to investigate whether i.v. lidocaine reduces the amount of alfentanil used during PSA in IBD patients. Additionally, we investigated whether lidocaine reduces cardiorespiratory incidents and the amount of propofol required during the procedure.Methods: A randomised, double-blind, placebo controlled study was performed at the endoscopy unit of the Radboud University Medical Centre from November 2016 to December 2018. Seventy-six patients with IBD, ASA 1 or 2, between 18 and 65 years, scheduled for colonoscopy with PSA were included. Patients received lidocaine 1.5 mg kg-1 followed by a continuous infusion of 2 mg kg-1 h-1 (intervention group, n=38) or 0.9% saline in equivalent volumes (control group, n=38) during colonoscopy.Results: There was a reduction in the use of alfentanil (327µg (95%CI=-31-505, p=0.082)), and propofol (39 mg (95%CI=-5-83, p=0.083)) in the lidocaine group compared with the control group. Ten patients (26%) in the control group and 8 patients in the lidocaine group (21%) experienced a period of hypoxia (p=0.788). In both groups, no periods of hypotension were noted.Conclusion: Our investigation has shown a reduction in the use of propofol and alfentanil in patients undergoing colonoscopy with PSA. The differences were not statistically significant. Lidocaine did not reduces the incidence of cardiorespiratory events.Trial registration:EudraCT, 2016-002210-46, registered 19 may 2016,https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-002210-46/resultsISRCTN, ISRCTN47787339, retrospectively registered 6 February 2019, http://www.isrctn.com/ISRCTN47787339
Bibliometric and Trend Analysis of Budget Transparency
Authors: Molotok Ihor Fedorovych
Published: July 2020

Over the last few decades, an integral part of public finance development is budget (fiscal) transparency and accountability. It is also in the focus of scientific interest and international organizations’ activity. Nevertheless, there is still a lack of valuable empirical research on identifying key triggers and inhibitors of budget (fiscal) transparency and its cohesion with other concepts in public finance management. Thus, this research deals with the realization of several tasks: 1) identification of budget (fiscal) transparency genesis and its essence in modern terms; 2) clarification of its cohesion with other concepts in public finance management using modern tools of bibliometric analysis; 3) characteristics of a current state of budget transparency in Ukraine, identification problems and prospects in this sphere. The second task fulfillment is based on Google Ngram Viewer, Google Trends, and VOSviewer bibliometric tools. Implementation of Google Ngram Viewer is aimed at popularity quantification of the concepts “budget transparency”, “fiscal transparency” and “budget accountability” in English Google books for 1960-2012. It defines budget (fiscal) transparency and accountability became the focus of scientific interest starting from 1960th, demonstrating an increase from the 1990th, and peaked in 2005. Google Trends analysis also showed that the peak of Internet users’ interest in budget (fiscal) transparency issues was in 2005-2006. Moreover, Google Trends analysis and frequency of Scopus articles published on the budget (fiscal) transparency issues lead to the conclusion that this concept remains popular among both scientists and regular Internet users worldwide. VOSviewer analysis of 419 Scopus articles reveals that budget (fiscal) transparency closely connected with economic prosperity and sustainability at national and local levels, poverty elimination, environmental responsibility, democratic values implementation, fight against corruption, good governance, and especially the efficiency of public finance management, fiscal policy, and government expenditures. Finally, analysis of budget transparency level in Ukraine based on Open Budget Survey 2019 allows concluding that despite the general improvement of the country score (from 54 to 63 points) in comparison with the previous Survey period, Ukraine still has problems with Mid-Year Review and Pre-Budget Statement.

Keywords: Bibliometric Analysis, Budget Accountability, Budget Transparency, Google Ngram, Google Trends, Fiscal Transparency, VOSviewer.
Padrões de consumo de energia no sector residencial: uma revisão bibliográfica
Authors: Manuel Manuel Tomás , Victorino Alfiado
Published: July 2020

O presente artigo tem como objectivo analisar as produções científicas nacionais e internacionais, que abordam a temática dos padrões de consumo de energia no sector residencial como referência para estudo dos padrões de consumo doméstico de energia no Bairro Nhaconjo, Cidade da Beira, no centro de Moçambique. Para tal analisamos cerca de 26 artigos científicos publicados em revistas científicas indexadas, nas últimas três décadas. Os resultados demonstram a existência de muitos estudos que tratam dos padrões de consumo doméstico de energia em países desenvolvidos, porém pouca literatura trata do assunto referente a Moçambique. A literatura revista também se mostra enfática em relação as diferenças em termos de agregados familiares, nível de rendimento, idade, escolaridade, hábitos do usuário, entre outros factores que influenciam directamente os comportamentos relacionados com o consumo de energia.
Relações entre padrões de consumo doméstico de energia e níveis de renda familiar: estudo de caso no 14o Bairro Nhaconjo, Cidade da Beira, Moçambique
Authors: Manuel Manuel Tomás , Victorino Alfiado
Published: July 2020

Este artigo analisa o impacto da renda sobre os padrões de consumo doméstico de energia no 14o. Bairro urbano denominado Nhaconjo, localizado no Município da Cidade da Beira, no centro de Moçambique. Com base no questionário, as famílias inqueridas foram classificadas em nove grupos de níveis de renda. Os resultados confirmam a hipótese de que com o aumento da renda o consumo doméstico de energia tende a aumentar, mas a um ritmo desigual. Também, foi possível verificar que quanto menor for a renda há mais participação de combustíveis que se encontra na base inferior da "escada de energia", no caso da lenha e serradura.
Padrões de consumo de energia no sector residencial: estudo de caso no 14o Bairro Nhaconjo, Cidade da Beira, Moçambique
Authors: Manuel Manuel Tomás , Victorino Alfiado
Published: July 2020

Com a finalidade de compreender as dinâmicas envolvidas no uso de energia nas famílias, este artigo analisa os padrões de consumo doméstico de energia dos agregados familiares residentes no 14o. Bairro Nhaconjo, na Cidade da Beira, no centro de Moçambique. Os dados foram recolhidos usando, primeiramente, um levantamento bibliográfico e documental e depois utilizou-se inquérito por questionário e medições directas como instrumento de colecta de dados. Os resultados mostraram que os padrões de consumo doméstico de energia foram muito diferenciados, e em termos do consumo de energia útil, destaca-se a electricidade com uma média de 217 MJ/mês e 444,5 kWh/per capita, o carvão vegetal com 1.199 MJ/mês e 421,8 kg/per capita, o GLP com 528 MJ/mês e 40,9 kg/per capita, a lenha com 278 MJ/mês e 34,3 kg/per capita, a serradura com 109 MJ/mês e 3,9 kg/per capita, a querosene com 31 MJ/mês e 0,37 L/per capita, a vela com 46 MJ/mês e 4 velas/per capita, e por último a pilha com 4,8 x 10^-13 MJ/mês e 4,4 V/per capita. Os combustíveis mais preferidos pelas famílias em causa é a electricidade e o carvão vegetal.
SIMULAÇÃO NUMÉRICA DA ADVECÇÃO-DIFUSÃO UNIDIMENSIONAL EMPREGANDO UM MODELO COM DERIVADAS FRACIONÁRIAS
Authors: Scotton Jaque Willian , Suarez Julian Moises Sejje , Goulart Antonio Gledson Oliveira
Published: July 2020

Neste trabalho, apresentamos os resultados obtidos na realização de simulações numéricas do problema estacionário de advecção-difusão unidimensional considerando, diferentemente da maioria dos trabalhos reportados na literatura, uma modelagem numérica baseada na equação da advecção-difusão com derivadas de ordens fracionárias. Para a realização do estudo, foram empregadas derivadas fracionárias de ordem ? conforme a definição de Riemann-Liouville, discretizadas numericamente pelo Método das Diferenças Finitas, utilizando a fórmula de Grünwald-Letnikov, com o objetivo de verificar a influência das ordens das derivadas nos perfis de solução de um problema sujeito a condições de contorno de Dirichlet, com velocidade constante e com coeficiente de difusão variável. Os valores considerados para as ordens das derivadas foram números reais pertencentes ao intervalo (0,1), tendo a modelagem fracionária sido validada com base na solução anal?tica para um caso espec?fico onde ? = 1. Nesse procedimento, fez-se a ordem das derivadas fracionárias ser muito próxima de 1 esperando que os resultados numéricos obtidos fossem muito próximos dos resultados analíticos para o caso  inteiro, o que de fato foi constatado, validando a modelagem. Os resultados obtidos para as demais situações analisadas evidenciaram que os valores de concentração, C, ao longo do dom?nio tornam-se menores quanto menores forem as ordens das derivadas.
ANÁLISE NUMÉRICA DA INFLUÊNCIA DAS DIMENSÕES DE PERFURAÇÕES EM PERFIS FORMADOS A FRIO DO TIPO RACK SUBMETIDOS À COMPRESSÃO
Authors: De Souza Flávio Teixeira , Dos Santos Elves Tiago , Sarmanho Arlene Maria Cunha
Published: July 2020

Os sistemas de armazenagem industrial, normalmente chamados racks, são formados por perfis formados a frio em aço com perfurações para acomodar as ligações. A seção utilizada nas colunas é susceptível à flambagem distorcional, cujo dimensionamento normativo é feito por meio do Método da Resistência Direta. Como este método não considera as perfurações, este trabalho avalia sua adaptação para ser utilizado em sistemas de armazenagem industrial, com foco na flambagem distorcional de elementos sob compressão. Para isto, a análise de estabilidade requerida no Método da Resistência Direta foi feita por meio do software GBTul, considerando a redução da espessura da chapa para considerar o efeito das imperfeições. Foram ainda simuladas 300 colunas via elementos finitos, utilizando-se o software ANSYS. Os modelos numéricos foram construídos com um procedimento calibrado experimentalmente em trabalhos anteriores, servindo, portanto, como referência para a avaliação das adaptações do Método da Resistência Direta. Os resultados indicaram que a adaptação do Método da Resistência Direta para a avaliação de perfis formados a frio com perfurações é viável, desde que se considerem adequadamente o modo de flambagem preponderante para a seção. Indica também que o método proposto neste trabalho, que relaciona a esbeltez da coluna com perfurações e da coluna sem perfurações, é bastante promissor.
PROJETO DE UMA FONTE DE ALIMENTAÇÃO ININTERRUPTA PARA CARGAS CC COM CONTRIBUIÇÃO SOLAR POR MÓDULOS FOTOVOLTAICOS
Authors: Leite Gelon de Freitas , Scharlau César Cataldo , Rampinelli Giuliano Arns
Published: July 2020

O recente impulso em direção às tecnologias verdes, juntamente com o aumento atual das cargas eletrônicas em Corrente Continua (CC), traz vantagens potenciais no uso de Micro Redes em CC (MRCC). Entre as vantagens, pode-se citar a possibilidade de um número menor de conversões na alimentação de cargas CC com energia gerada por Módulos Fotovoltaicos (MF). No momento que adiciona-se, a este cenário, cargas que necessitem de alta disponibilidade, surgem possibilidades para o estudo e desenvolvimento de uma fonte de alimentação interrupta, do inglês, Uninterruptible Power Supply (UPS), como uma alternativa de alta eficiência e de menor custo ao disponibilizar energia proveniente de fonte de energia renovável, do inglês, Renewable Energy Sources (RES) à cargas eletrônicas. Neste trabalho, será apresentado o projeto e os resultados experimentais de uma MRCC para a alimentação de cargas com necessidade de UPS. O conjunto foi implementado em uma edificação na qual funciona um ofício de registro de imóveis e a alimentação utiliza MF. Os resultados experimentais demonstram que a carga pode ser alimentada 94% do tempo com energia proveniente dos MF. A análise financeira indicou que o custo adicional, gerado ao escolher a presente metodologia ao invés de um UPS tradicional em Corrente Alternada (CA), possui uma taxa interna de retorno de 46,6%, um retorno simples de 3,0 anos e de capital próprio de 2,5 anos.
SIMULAÇÃO E ANÁLISE DE SISTEMA FOTOVOLTAICO CONECTADO À REDE COM BATERIA INTEGRADA AO INVERSOR NO ÂMBITO DA TARIFA BRANCA
Authors: Rodrigues Aline , Rampinelli Giuliano Arns
Published: July 2020

Os consumidores residenciais brasileiros conectados à rede elétrica pagam um valor de tarifa correspondente à energia elétrica consumida, que pode ser a tarifa convencional ou a branca. A tarifa branca tem diferentes valores de tarifa para os períodos do dia, os quais são horários de ponta, intermediário e fora de ponta. A tarifa convencional, tem apenas um valor fixo de tarifa, independente do horário e dia da semana. No Brasil, a Resolução Normativa ANEEL nº 482/2012 estabelece as condições gerais da geração distribuída, que está relacionada a geração de energia elétrica próxima ao consumidor. Atualmente, a fonte mais utilizada pelos consumidores brasileiros na geração distribuída é a energia solar fotovoltaica. O sistema fotovoltaico conectado à rede e que dispõe de inversor com bateria integrada, apresenta a possibilidade de armazenar energia na bateria e descarregar nos horários selecionados. Neste artigo será apresentado a simulação e análise de sistemas fotovoltaicos conectados à rede e com bateria de 2, 4 e 10 kWh integrada aos inversores no âmbito da tarifa branca. A fim de analisar se a tarifa branca aliada a sistemas fotovoltaicos e armazenamento de energia pode ser atrativa ao consumidor residencial. Os resultados consistiram em comparações sobre o valor do faturamento correspondente à energia elétrica da rede, à energia injetada na rede, aos créditos de energia, bem como, o custo da fatura de energia elétrica, sendo que esses parâmetros são dependentes da curva de carga do consumidor.
ANÁLISE DA EFICIÊNCIA OPERACIONAL DOS CURSOS DE DIREITO DO ESTADO DE MINAS GERAIS POR MEIO DA ANÁLISE ENVOLTÓRIA DE DADOS
Authors: Sousa Aguinelo Antônio de , Santos Gisele Tessari
Published: July 2020

A educação formal provoca impactos diretos na economia de um país, se tornando, assim, algo de grande relevância. Este fato destaca a importância de se avaliar a eficiência de cursos das instituições de ensino superior (IES). Este trabalho teve como objetivo determinar o índice de eficiência relativa dos cursos de direito de Minas Gerais (MG), Brasil, identificar os cursos benchmarks e a partir destes resultados, determinar um ranking de eficiência entre os cursos de direito de MG. Para tal análise, utilizaram-se os modelos clássicos, CCR e BCC, da técnica de Análise Envoltória de Dados (Data Envelopment Analysis) (DEA), ambos orientados à saída (output). Foram analisados 125 cursos de direito. Sob a ótica dos dois modelos utilizados, apenas 12% dos cursos foram considerados 100% produtivamente eficientes. A média de eficiência dos cursos obtida pelos modelos CCR e BCC foi de 79% e 84%, respectivamente. Resultados obtidos por meio da resolução dos modelos matemáticos apontam grandes oportunidades para melhoria dos cursos ineficientes. Portanto, os resultados deste estudo podem auxíliar à tomada de decisão apontando possíveis mudanças organizacionais que visem o aumento da eficiência dos cursos de direito analisados.
Assessment of land cover resolution impact on flood modeling uncertainty
Authors: Fan Jihui , Galoie Majid , Motamedi Artemis , Huang Jing
Published: July 2020

The main objective of this paper is to evaluate the impact of land cover resolution, in comparison with the digital elevation model (DEM) resolution, on hydrological modeling outputs. Three different basins in the various resolutions of DEM (12.5, 25, 50, 100, 500 and 1,000 m) and land-use maps (250, 1,000 and 2,500 m) were collected in this study, and the hydrological modeling process was performed using the Soil and Water Assessment Tool (SWAT) model. The soil type resolution was 1,000 m for all basins, and the runoff modeling was done based on the Soil Conservation Service Curve Number (SCS-CN) method. The final model outputs showed that the DEM cell size variations affect significantly the topographical characteristics of a catchment such as area, mean slope, river network and time to concentration which alter the flood modeling outputs especially in hilly watersheds (mean slope more than 15%) up to 15% for a DEM cell size of 1,000 m in comparison to 12.5 m. Also, the resolution and spatial distribution of land cover maps which directly specify SCS-CN values, can change the output simulated runoff results up to 49% for a land cover cell size of 2,500 m in comparison to 250 m. These results indicated that the quality of the land cover map is more important than the quality of DEM in hydrological modeling. Also, the results showed that for an identical land-use cell size, the differences between model outputs using DEM cell sizes less than 100 m were not very significant. Furthermore, in all models by increasing the DEM cell size, the simulated runoff depth was decreased.
Development of an assessment tool for infrastructure asset management of urban drainage systems
Authors: Igroufa Meriem , Benzerra Abbas , Seghir Abdelghani
Published: July 2020

The present paper deals with the improvement of infrastructure asset management of urban drainage systems (UDS). A numerical tool for assessing the existing management procedures is proposed. It is based on a participatory methodology for the construction of a set of performance indicators. This methodology consists of two phases. The first concerns the identification of priority objectives, criteria and indicators related to the management of the UDS infrastructure. The second phase concerns the assessment of the global performance for each identified objective. Performance measurement scales are first defined for all the elements of the proposed methodology. Then, the Fuzzy Analytical Hierarchy Process (FAHP) is used for the weighting stage, and the Weighted Sum Method is used for the aggregation of indicators and criteria. To illustrate this methodology, a case study concerning Bejaia City in northern Algeria was carried out. Two priority objectives are identified for this case, they are divided into 6 criteria and 31 indicators. The results of the application of the developed tool highlighted some weaknesses that need improvements in the actual management procedure applied by the local sanitation services.
Informatization of the process of independent preparation for the State Final Examination (SFE)
Authors: Khlopova Daria Evgenevna
Published: July 2020

This article is devoted to Information Technologies designed to help students during their preparation for the State final certification.
Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery
Authors: Agarwal Shriya , Agarwal Vinayak , Agarwal Mugdha , Singh Manisha
Published: July 2020

In recent times, several approaches for targeted gene therapy (GT) had been studied. However,
the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between
cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing
with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the
most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural
access through every biological membrane and can be employed for site-specific and efficient drug
delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also,
there are many research studies conducted in the last few decades on using exosome-mediated gene
therapy into developing an effective therapy with the concept of a higher degree of precision in gene
isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review
discusses several facets that contribute towards developing an efficient therapeutic regime for gene
therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic
regimes.
Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental Observations and Molecular Mechanics
Authors: Singh Manmeet , Singh Dilpreet , Mahajan Sundar , Sheikh Bilal Ahmed , Bedi Neena
Published: July 2020

Background:

Supersaturable SMEDDS, a versatile dosage form, was investigated for improving
the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug
efavirenz.

Objective:

The present research pursues development of efavirenz loaded supersaturable self-microemulsifying drug delivery system (SS SMEDDS) for improving biopharmaceutical performance.

Methods:

Preformulation studies were carried out to determine the optimized range of lipid excipients
to develop stable supersaturated SMEDDS (ST SMEDDS). The SS SMEDD formulation was prepared
by adding hydroxypropyl methylcellulose as a polymeric precipitation inhibitor. The developed SS
SMEDDS were evaluated for supersaturation behavior by performing in vitro supersaturation studies
and molecular simulations by in silico docking. Dissolution was performed in biorelevant media to simulate
fed/fasted conditions in gastrointestinal regions. Absorption behavior was determined through in
vivo pharmacokinetics approach.

Results:

The optimized ST SMEDDS formulation containing Maisine® CC, Tween 80 and Transcutol-P
exhibited thermodynamic stability with quick rate of emulsification. The optimized SS SMEDDS containing
suitable polymeric precipitation inhibitor exhibited enhanced efavirenz concentration in in vitro
supersaturation test. The theoretical simulations by molecular docking revealed strong intermolecular
interactions with a docking score of -3.004 KJ/mol. The dissolution performance of marketed product in
biorelevant dissolution media inferred the existence of food effect in the dissolution of efavirenz. However,
in SS SMEDDS, no significant differences in drug release behavior under different fasted/fed
conditions signify that the food effect was neutralized. In vivo pharmacokinetics revealed a significant
increase in the absorption profile of efavirenz from SS SMEDDS than that of ST SMEDDS and marketed
product.

Conclusion:

The designed delivery system indicated promising results in developing an effectual EFV formulation for HIV
treatment.
Drug Re-purposing from SARS-CoV Led the Identification of Potential Candidate Drug Target and Alternate Drug Molecules Against SARSCoV- 2
Authors: Arun PV Parvati Sai , Hussain Razak , Akhter Yusuf , Rao Mandava Venkata Basaveswara , Shyam Perugu , Yellaboina Sailu
Published: July 2020

Background:

SARS-CoV-2 causes COVID19 disease where there are no suitable drugs
available.

Objective:

The objective of the work is to repurpose the drugs prescribed for SARS-CoV as the
drugs for the control of SARS-CoV-2.

Methods::

In this work, we have used homology searches and docking methods for understanding
the mechanism of the drugs prescribed for the control of SARS-CoV on SARS-CoV-2.

Results:

In our analysis, we found that the drugs Benzyl (2-Oxopropyl)carbamate, 2-[(2,4-Dichloro-
5-methyl phenyl)sulfonyl]-1,3-dinitro-5-(trifluoromethyl)benzene, S-[5-(Trifluoromethyl)-4H-1,2,4-
triazol-3-YL] 5-(phenylethynyl)furan-2-carbothioate, 4-(Dimethylamino)benzoic acid, which are
capable of inhibition of the activity of 3CLPro and prevent the progression of SARS-CoV.

Conclusion:

In this letter, we describe the findings of the protein ligand interactions between 3CLPro
of SARS-CoV, SARS-CoV-2 with Benzyl (2-oxopropyl) carbamate.
Spontaneous Adverse Drug Reaction Monitoring in a Tertiary Care Centre
Authors: Kaur Kirandeep , Kanwal Preet , Goyal Pardeep , Singh Paramjit , Yakhmi Sahil , Jain Samriti , Kaushal Sandeep
Published: July 2020

Background and Objective:

Adverse drug reactions (ADRs) are associated with increased
economic burden on the society. Monitoring of ADRs can help in decreasing the incidence
of preventable adverse reactions.

Methods:

Under Pharmacovigilance Program of India, collection and reporting of ADRs has been
going on at Dayanand Medical College and Hospital since January 2011. Here, we have analyzed
the individual case safety reports (ICSRs) reported and uploaded between January 2017 and June
2019 from our centre. The ADR form provided by PvPI was used for collecting information, and
the causality assessment was done according to the WHO-UMC scale.

Results:

A total of 498 ICSRs were uploaded through Vigiflow software during this period. Highest
number of ADRs were recorded in the age group of 31-45 years (29.01%) and the least number of
ADRs were recorded in the children less than 15 years of age (6.76%). General Medicine ward reported
the highest number of ADRs and the antibiotics were most commonly associated with ADRs
(26.21%), followed by antipsychotics (13.83%) and NSAIDs (12.14%). More than 90% of ADRs
were non-serious (93.17%) and most of the ADRs were skin and soft tissue related (49.20%).

Conclusion:

Spontaneous reporting among indoor patients shows highest number of ADRs with use
of antibiotics and almost all of the ADRs were non-serious in nature. Almost half of the total ADRs
were skin and subcutaneous tissue related. Continuous efforts are required for further strengthening
of the pharmacovigilance program of India.
Superior Mesenteric Venous (SMV) Thrombosis Accompanied with Appendicitis in a Patient with Primary Diagnosis of Typhoid Fever
Authors: Adibimehr Alireza , SeyedAlinaghi SeyedAhmad , Nourian Anahid , Mehrabi Zeinab , Moslemi Rohollah
Published: July 2020

Background:

Septic thrombophlebitis of the Superior Mesenteric Venous (SMV) is rarely
accompanied by appendicitis, and symptoms are atypical, so the diagnosis is commonly delayed,
resulting in it is associated with high mortality.

Case Presentation:

We report a case of neglected SMV septic thrombophlebitis is caused by appendicitis.
The patient represented with fever, vague abdominal pain without rebound tenderness, and
history of the consumption of contaminated water. Antibiotic initiated due to suspicious typhoid
fever. Then typhoid fever was ruled out. Computed tomography (CT) scans revealed micro-abscess
forming complicated appendicitis and the thrombus in SMV.

Discussion and Conclusion:

The patient underwent a laparoscopic appendectomy, during which
retrocecal gangrened perforated appendix with a 2×2 cm abscess was drained. Based on positive
culture with ESBL organism meropenem was initiated. Appendectomy and treatment with broad-
-spectrum antibiotics and anticoagulation led to a full recovery.
Suitable Signal Peptides for Secretory Production of Recombinant Granulocyte Colony Stimulating Factor in Escherichia coli
Authors: Tehrani Sadra S. , Goodarzi Golnaz , Naghizadeh Mohsen , Khatami Seyyed H. , Movahedpour Ahmad , Abbasi Ali , Shabaninejad Zahra , Khalaf Nesa , Taheri-Anganeh Mortaza , Savardashtaki Amir
Published: July 2020

Background:

Granulocyte colony-stimulating factor (G-CSF) expressed in engineered Escherichia coli (E. coli) as a recombinant protein is utilized as an adjunct to chemotherapy for improving neutropenia. Recombinant proteins overexpression may lead to the creation of inclusion bodies whose recovery is a tedious and costly process. To overcome the problem of inclusion bodies, secretory production might be used. To achieve a mature secretory protein product, suitable signal peptide (SP) selection is a vital step.

Objective:

In the present study, we aimed at in silico evaluation of proper SPs for secretory production of recombinant G-CSF in E. coli.

Methods:

Signal peptide website and UniProt were used to collect the SPs and G-CSF sequences. Then, SignalP were utilized in order to predict the SPs and location of their cleavage site. Physicochemical features and solubility were investigated by ProtParam and Protein-sol tools. Fusion proteins sub-cellular localization was predicted by ProtCompB.

Results:

LPP, ELBP, TSH, HST3, ELBH, AIDA and PET were excluded according to SignalP. The highest aliphatic index belonged to OMPC, TORT and THIB and PPA. Also, the highest GRAVY belonged to OMPC, ELAP, TORT, BLAT, THIB, and PSPE. Furthermore, G-CSF fused with all SPs were predicted as soluble fusion proteins except three SPs. Finally, we found OMPT, OMPF, PHOE, LAMB, SAT, and OMPP can translocate G-CSF into extracellular space.

Conclusion:

Six SPs were suitable for translocating G-CSF into the extracellular media. Although growing data indicate that the bioinformatics approaches can improve the precision and accuracy of studies, further experimental investigations and recent patents explaining several inventions associated to the clinical aspects of SPs for secretory production of recombinant GCSF in E. coli are required for final validation.
Enhanced Solubility and Permeability of Naringenin Across Non-Everted Sacs of Rat Small Intestine by Lipid Nanocapsules
Authors: Vakilzadeh Hamed , Varshosaz Jaleh , Soghrati Sahel
Published: July 2020

Background:

Naringenin (NRG) has many health benefits, including; anti-atherogenic, antiinflammatory,
antitumor, and anticancer activity, as well as improvement of lipid metabolism. However,
its use is limited due to its low solubility and bioavailability.

Objectives:

The aim of the present patent study was the preparation and optimization of NRG loaded
Novel Lipid Nanocapsules (LNCs) for the improvement of NRG solubility and gut permeability.

Methods:

Studied variables included; Solutol® HS15 and NRG concentration and the ratio of cold diluent
water to primary emulsion. The storage stability of the LNCs was evaluated for 32 days and thermal
analyses were conducted by Differential Scanning Calorimetry (DSC). The antioxidant properties
of the NRG in LNCs were studied by measuring the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical
scavenging activity. The enhancement of permeation of NRG by the LNCs from the intestine was
evaluated by the non-everted gut sac method.

Results:

The optimized NRG-LNCs had a hydrodynamic diameter of 29.41±1.25 nm, a low polydispersity
index, and high entrapment efficiency of 99.25±2.31%. The LNCs could retain NRG radical
scavenging activity, showed good storage stability, and significantly improved NRG solubility (69
fold) and permeation through non-everted rat intestinal sac (4.33 fold).

Conclusion:

LNCs of NGR enhance solubility and intestinal permeability of this flavonoid and may be
useful in the improvement of its bioavailability.
Role of Deposition Pressure on Properties of Phosphorus Doped Hydrogenated Nano-Crystalline Silicon (nc-Si:H) Thin Films Prepared by the Cat-CVD Method
Authors: Gabhale Bharat , Waghmare Ashish , Pandharkar Subhash , Bhorde Ajinkya , Nair Shruthi , Vairale Priti , Doiphode Vidya , Shinde Pratibha , Punde Ashvini , Hase Yogesh , Patil Nilesh , Prasad Mohit , Jadkar Sandesh
Published: July 2020

Objective:

Phosphorus doped hydrogenated nano-crystalline silicon (nc-Si:H) thin
films were synthesized by catalytic chemical vapor deposition (Cat-CVD) method.

Methods:

The effect of deposition pressure on opto-electronic and structural properties was
studied using various analysis techniques such as low angle XRD analysis, FTIR spectroscopy,
Raman spectroscopy, UV-Visible spectroscopy, dark conductivity, etc.

Results:

From low angle XRD and Raman spectroscopy analysis, it is observed that an increase
in deposition pressure causes Si:H films to transform and transit from amorphous to
the crystalline phase. At optimized deposition pressure (300 mTorr), phosphorous doped nc-
Si:H films having a crystallite size of ∼29 nm and crystalline volume fraction of ∼58% along
with high deposition rate (∼29.7 Å/s) have been obtained. The band gap was found to be
∼1.98 eV and hydrogen content was as low as (∼1.72 at. %) for these films.

Conclusion:

The deposited films can be useful as an n-type layer for Si:H based p-i-n,
tandem and c-Si hetero-junction solar cells.
Afonso, Raquel: Homossexualidade e resistência no Estado Novo Ourém: Lua elétrica, 2019, 256 pp.
Authors: Carvalho Ana Bessa
Published: July 2020

“Mário” é um monólogo de Fernando Heitor que estreou em agosto de 2019,cerca de setenta anos depois das primeiras perseguições e condenações a Valentim de Barros, um bailarino homossexual que viveu durante o Estado Novo (em quem o Mário da peça é baseado). Durante grande parte da sua vida, Valentim foi perseguido, diagnosticado com diversas patologias (os nomes da época não permitem entender qual era a identidade sexual de Valentim, dada a confusão entre uma orientação sexual homossexual, uma identidade transgénera ou até crossdressing) acabando por ser sujeito a uma lobotomia que lhe foi, assim como todos os outros tratamentos, imposta por um estado e um discurso médico marcadamente heteronormativos e patriarcais, morrendo no Hospital Miguel Bombarda, onde ‘viveu’ durante anos a fio.
A re-emergência literária de vozes e memórias femininas silenciadas durante a ditadura militar brasileira
Authors: Eugenio Alessia Di
Published: July 2020

As vozes das mulheres brasileiras, hoje em dia, incomodam muito o poder político conservador, que tenta continuamente (re)estabelecera prioridade da fala dos homens e a ilegitimidade da presença das mulheres como sujeito político no espaço público. Em particular, neste momento político é interessante olhar para as experiências de mulheres que viveram e lutaram durante outro momento brutalmente conservador da história brasileira, aquele dos vinte e um anos da ditadura civil-militar. Relativamente a essa geração, este artigo aborda textos de Maria Pilla e Maria Valéria Rezende. Recordar estas mulheres é tanto mais importante porque o governo Temer e o governo Bolsonaro construíram uma conexão explícita com a época da ditadura, e porque o surgimento do movimento feminista brasileiro está ligado à história da participação das mulheres na luta de oposição ao autoritarismo dos anos 60 e 70. Através de uma reconstrução das publicações de depoimentos e relatos de mulheres e romances escritos por mulheres, queremos refletir sobre o processo de transmissão da memória feminina da luta contra a ditadura –entre remoção histórica e re-emergência literária –e sobre a temporalidade desta memória, para entender melhor a sua herança em relação às lutas que enfrentam hoje as mulheres brasileiras. Nesse sentido, este artigo aborda também duas autoras de uma geração subsequente, que abordam nas suas obras asmemórias familiares e privadas da ditadura. Trataremos textos de Adriana Lisboa e Liliane Hang Brum.
Resiliência criativa no feminino e re-significação da história em contraponto com a ‘manipulação de género’ do Estado Novo
Authors: Macedo Ana Gabriela
Published: July 2020

Este ensaio é composto por duas secções que dialogam entre si e se iluminam reciprocamente. Discute-se em primeiro lugar a imagem icónica de Salazar enquanto ‘salvador moral da pátria’, incarnando a figura do ‘Desejado’, tal como construída e amplamente disseminada pela ideologia do Estado Novo, tendo António Ferro como seu principal mentor e ideólogo cultural. Discute-se de seguida o modo como o ‘discurso da domesticidade’, profundamente ancorado numa dupla premissa –a manipulação de género e a cumplicidade das mulheres –se constituiu como uma ideologia fundamental de sustentação do Estado Novo. Na segunda parte deste ensaio apresentamos um estudo de caso, a obra da pintora Paula Rego criada ao longo dos anos 1960 e 1970, a qual, com acutilância satírica e política, desconstrói, expõe e confronta essa mesma ideologia do poder instituído.
Matéria impressa, matéria nómada: sobre o potencial ideológico das publicações de artista
Authors: Oliveira Márcia
Published: July 2020

Em contextos de ditadura e repressão, o movimento adquire enorme potencial em termos da sua capacidade de disrupção e de resistência (estética). Através do exílio, da migração, da viagem ou da correspondência, corpos, ideias e objectos são permanentemente deslocados, numa procura incessante de linhas de fuga impossíveis de fixar por qualquer regime político. No campo das artes visuais, a natureza elusiva e mutável do movimento tem a capacidade de transformar objectos em eventos, criando redes afectivas de imagens, palavras, objectos, ideias e relações. O potencial ideológico do movimento encontra-se de forma bastante vívida nas publicações de artista, ou na arte em forma de matéria impressa, tal como livros de artista ou mail art, os quais conseguem contornar as limitações físicas impostas por aparelhos repressivos. Da mesma forma, o movimento activa a imaginação, impele-a a juntar elementos de uma rede de colaborações que é assim construída e posta, também, em movimento. O exercício a que nos propormos com este artigo implica olhar mais de perto certas condições materiais e históricas inerentes a certos objectos artísticos, condições essas que os impregnam de camadas ideológicas diversas. Assim, ao considerar a triangulação movimento-tempo-espaço, tenho o objectivo de investigar a forma como várias artistas, mulheres, usaram diferentes tipos de matéria impressa para rever, confrontar e pôr a nu certas narrativas totalizantes, tais como o papel das mulheres na sociedade, o capitalismo, a escravatura, o colonialismo, etc., que foram sustentadas e simultaneamente sustentaram os regimes repressivos e ditatoriais que vigoraram em Portugal e no Brasil.
CONSTRUCTION OF THE FOREST SCHOOL FRAMEWORK BASED ON INDIGENOUS KNOWLEDGE IN MALAYSIA
Authors: Wahab Norwaliza Abdul , Goh Pauline Swee-Choo , Ong Eng-Tek , Ibrahim Mohd Hairy , Affandi Haryanti Mohd
Published: July 2020

The rate of drop outs among indigenous or Orang Asli pupils in primary school is a worrying issue. They were found to be unable to apply the knowledge acquired through formal education systems in Malaysia due to the different 'setting' of the environment. This failure was due to the lack of understanding on how Orang Asli pupils learn, think, and act. The aim of this study was to construct a Forest School framework for the teaching and learning process in Orang Asli primary schools. The qualitative study design involved in-depth interviews with six experts from the Orang Asli community by using semi-structured questions to explore and clarify related sub-constructs. The results showed five elements that need to be incorporated in the syllabus were: indigenous music, herbs and medicine, handicrafts, tools for hunting and forestry. The Forest School framework would serve as a comprehensive guide and reference for policymakers as indigenous knowledge elements need to be incorporated in primary school's syllabus to ensure life sustainability of Orang Asli in the forest. Teachers could take advantage to help Orang Asli pupils to feel more enthusiastic and motivated in processing the knowledge given in classrooms as it hits close to their environment.