bluuebunny/crossref_metadata_2025 huggingface dataset:
Breast Self-Examination Practice and Associated Factors Among Reproductive Age Women In North Shewa Zone, Oromia, Ethiopia, 2022: By Using Health Belief Model
Authors: Hussein Dursa , Gashaw Ketema , Geleta Tinsae Abay , Girma Derara , Geleta Leta Adugna , Oyato Befekadu Tesfaye
Published: February 2023

Background
Breast cancer is the leading cause of cancer death worldwide and the second most common cancer overall. Breast self-examination is one of the cheapest methods used for the early detection of breast cancer in asymptomatic women. However, in Ethiopia, most of the breast self-examination studies were not conducted among women in the general population. Therefore, this study aimed to assess breast self-examination practice and associated factors among women of reproductive age in the North Shewa Zone, Oromia.
Method
A community-based cross-sectional study was conducted in the North Shewa zone from May 18/2022 to June 18/2022. 1076 women of reproductive age were selected by simple random sampling. For the quantitative part of the study, an interviewer-administered questionnaire was used, and focus group discussions were used for the qualitative part. SPSS version 26 was used for the analysis. Variables with a P-value < 0.25 in the bivariable analysis were included in the multivariable logistic regression model. The degree of the association was expressed using an adjusted odds ratio (AOR) with a 95% confidence interval (CI) at a P-value < 0.05.
Results
Overall 192(18.2%) with 95% CI (15.7, 20.5) of the participants had ever performed BSE. Among these, only 20 (10.4%) had practiced monthly. Being younger-aged women (15–24) [AOR = 3.9, 95% CI (2.2–6.8)], having a family history of BC [AOR = 6.9, 95% CI (4.6–10.3)], being knowledgeable on BSE [AOR = 3, 95% CI (1.9–4.3)], having high perceived susceptibility [AOR = 1.7, 95% CI (1.2–2.5)], having high self-efficacy [AOR = 1.5, 95% CI (1.1–2.3)] and having a high perceived benefit to BSE [AOR = 1.5, 95% CI (1.1–2.3)] were factors significantly associated of BSE practice.
Conclusion
BSE practice in the North Shewa zone was very low. Age, family history of BC, knowledge of BSE practice, perceived susceptibility, benefit, and self-efficacy were independent predictors of BSE practice. North Shewa Zonal Health Office and other stakeholders should disseminate teaching materials that address the benefit of BSE practice.
Land Tenure Security and Climate Change Adaptation Strategies in Togo
Authors: TOBI Kossigan , EDGEWEBLIME Kcodgoh
Published: February 2023

The main objective of this paper is to analyze the effect of land tenure security on the adaptation strategies of agricultural households to climate change in Togo. By applying the multinomial logit model to data from the Harmonized Household Living Conditions Survey conducted by INSEED in 2018–2019, the results show that land tenure security positively and significantly affects the adaptation strategies of agricultural households in Togo. This result remains valid even if we apply ordinary least squares to the coping strategy index constructed from the principal component analysis. The study suggests policies to formally secure agricultural plots in Togo.
PSYCHOVEGETATIVE SYNDROME AS A CLINICAL MANIFESTATION OF ADAPTATION DISORDERS IN SENIOR MEDICAL STUDENTS
Authors: Kutura Mariana , Levchenko Valeriy
Published: February 2023

The objective of the paper was the verification of psychosomatic disorders against the background of disadaptation among senior medical students.
Materials and Methods. We used screening and psychometric diagnostic methods to examine 292 4th-year students, 181 (62 %) of whom showed signs of disorders relating to psychological and emotional adjustment to the stressful influence of external irritants against the background of somatic symptoms. We used the standardized Spielberger–Hanin, Zung, Cohen, and Nijmegen questionnaires and anamnestic data for the in-depth questionnaire in our research.
Results. When assessing the overall results of the psychometric screening, we found that more than half of the 4th-year students surveyed (62 %) had some signs of adjustment disorders. According to the Spielberger questionnaire, 43.65 % of students in the main group (n = 181) showed signs of increased state anxiety. The majority of young people showed signs of trait anxiety, among whom 53.04 % had severe anxiety disorders and 41.99 % had moderate anxiety disorders. According to the Zung questionnaire, 17 people showed signs of depression. The Cophen scale assessment revealed a high number of young people with low stress tolerance among respondents. We found that among 181 students, 35.36 % had a satisfactory result (6.8 ± 1.43 units) and 50.28 % had a poor result (28.2 ± 1.18 units). The remaining 10 students in this group had a very poor result (36.5 ± 2.16 units). 48 students in the main group showed positive results according to the Nijmegen questionnaire.
On the background of the detected changes, psychosomatic symptoms were established in most students, which can act as a marker of a non-adaptive type of autonomic reaction.
Conclusions. Screening assessment of medical students with the use of standardized questionnaires makes it possible to detect manifestations of psychovegetative dysfunction, disadaptation syndrome against the background of psychosomatic symptoms.
The forward-backward asymmetry and differences of partial moments in inclusive semileptonic $B$ decays
Authors: Herren Florian
Published: February 2023

Global fits to moments of kinematic distributions measured in
inclusive semileptonic B\rightarrow X_c l \nu_lB→Xclνl
enable the determination of the Cabibbo-Kobayashi-Maskawa matrix element
\left|V_{cb}\right||Vcb|
together with non-perturbative matrix elements of the heavy quark
expansion. In current fits, only two distinct kinematic distributions
are employed and, as a consequence, higher moments of these
distributions need to be taken into account to extract the relevant
non-perturbative matrix elements. The moments of a given distribution
are highly correlated and experimental uncertainties increase for higher
moments. To address these issues, Turczyk suggested the inclusion of the
charged lepton forward-backward asymmetry \mathcal{A}_{FB}𝒜FB
in global fits, since it provides information on non-perturbative
parameters beyond the commonly used moments. It is possible to construct
differences of partial moments of kinematic distributions, which can
provide additional information on the non-perturbative parameters beyond
\mathcal{A}_{FB}𝒜FB
and are studied in this work for the first time. Further, experimental
cuts on the four-momentum transfer square are studied and are shown to
preserve the shape of the angular distribution, in contrast to commonly
used cuts on the lepton energy. Finally, the impact of final-state
radiation and experimental lepton identification requirements on
measurements of \mathcal{A}_{FB}𝒜FB
and differences of partial moments are discussed.
Nexus between information technology investment and bank performance: The case of Jordan
Authors: Al-Amarneh Asma’a , Yaseen Hadeel , Bani Atta Anas , Khalaf Lubna
Published: February 2023

Bank stakeholders, such as creditors, investors, regulators, and other bank stakeholders, expect continuous performance improvement. To achieve this goal, bank managers can use information technology (IT) as a strategic resource to improve their bank’s capabilities and accordingly gain competitive advantage. In this study, the profitability and efficiency of commercial banks in Jordan are compared to investment in information technology (IT). Return on equity (ROE), return on assets (ROA), and net interest margin (NIM) are used to measure bank profitability while controlling for bank size and financial leverage. Cost efficiency is measured using the cost efficiency ratio. The study sample consists of 13 commercial banks listed on the Amman Stock Exchange between 2010 and 2021. To determine the relationship between the variables, descriptive statistics, correlation analysis, the panel least squares approach, and fixed effects multiple regression models are used. The findings show that banks, on average, spend 0.61 percent of their total assets on information technology (hardware and software). Additionally, banks that invest in IT are predicted to perform better over time, as evidenced by their increased profitability and efficiency. Small banks have more IT investment as a percentage of assets than larger banks. In comparison to highly leveraged banks, less leveraged banks typically have a greater IT investment to asset ratio (0.69%). The findings show that profitable banks (measured by ROE) invest more than 1.1% of their total assets in IT. Meanwhile, highly efficient banks also invest more in IT (0.65%) compared to less efficient banks.
AcknowledgmentWe are indebted to the Middle East University (MEU) - Jordan ) for the financial support needed for this article.
DESENVOLVIMENTO DE UM EQUIPAMENTO DE SPIN COATING COM SISTEMA DE FIXAÇÃO DE SUBSTRATO A VÁCUO EMPREGANDO MATERIAIS REUTILIZADOS
Authors: Chepluki Antonio , Frizon Tiago , de Carvalho Igor
Published: February 2023

DEVELOPMENT OF A SPIN COATING EQUIPMENT WITH A VACUUM SUBSTRATE FIXING SYSTEM USING REUSED MATERIALS. This work presents the development of a low-cost spin coater for thin film deposition as an alternative to commercial equipment that have high acquisition cost. The proposed spin coater uses a brushless motor taken from an unused hard disk, which is activated through the association of an electronic speed controller (ESC) and an Arduino microcontroller. During deposition, the rotating substrate is attached with a vacuum clamping system. For the control, the system uses a Hall effect sensor to read the engine speed. The rotation readings performed by the equipment sensor were validated with a tachometer. Finally, TiO2 films were deposited on glass substrates with ITO (Indium Tin Oxide) and characterized by UV-Vis spectroscopy to obtain the transmittance of the films at different rotation speeds.
PESTICIDES IN PROCESSED FOOD - MULTIRESIDUE PESTICIDES IN NATURAL GRAPE JUICES BY HIGHRESOLUTION MASS SPECTROMETRY
Authors: Chiarello Marilda , Crocoli Luana , Molon Vinícius , Moura Sidnei
Published: February 2023

Grapes are among the most widely cultivated fruits in the world, with the majority of Brazilian production focusing on natural grape juice. In this work, a total of 40 samples of 2 types of natural grape juice were analyzed for the presence of 86 pesticide residues, with multiresidue extraction based on modified QuEChERS, by liquid chromatography with high-resolution mass spectrometry (LC-HRMS). Limits of detection and quantification were below 6 μg L-1 and 20 μg L-1, RSD < 20%, R2 > 0.99 and recovery ranged from 80 and 120%. Thus, the developed method was validated and good performance characteristics such as linearity, trueness, repeatability and inter-day precision were obtained. As results, 7 pesticides were detected in real samples (azoxystrobin, benalaxyl, carbendazim, tebuconazol, thiophanate-methyl, pyriproxiphen and pyrimethanil). The method was successfully validated for simultaneous evaluation of 86 multiclass pesticides residues levels, which was applied in 40 natural white and red grape juice market samples. The limits of quantification (LOQs) were low enough and the method was tested on samples showing its applicability, and therefore, this method can be used in routine analysis. Also, this work therefore also serves as an alert regarding the contamination of processed products.
Faktor Lingkungan, Motivasi, dan Beban Kerja dalam Loyalitas Karyawan
Authors:   Fakultas Ekonomi dan Bisnis, Universitas Mercu Buana, Jl. Meruya Selatan No.1, RT.4/RW.1, Meruya Selatan, Kec. Kembangan, Kota Jakarta Barat, Daerah Khusus Ibukota Jakarta 11650, Indonesia, Kurniati Nia , Riyanto Setyo ,   Fakultas Ekonomi dan Bisnis, Universitas Mercu Buana, Jl. Meruya Selatan No.1, RT.4/RW.1, Meruya Selatan, Kec. Kembangan, Kota Jakarta Barat, Daerah Khusus Ibukota Jakarta 11650, Indonesia
Published: February 2023

This study aims to analyze and determine the effect of Work Environment, Work Motivation and Workload on Employee Loyalty at PT. Mowilex Indonesia. The population in this study were 310 employees of PT. Mowilex Indonesia. The sample used was 175 respondents, calculated based on the Slovin formula with a convenience sample technique. Methods of data collection using survey methods, with the research instrument is a questionnaire. Data analysis method used SPSS statistic 25 for descriptive analysis and Structural Equation Model with SmartPLS 3.0. This study proves that the work environment has a positive and significant effect on employee loyalty, work motivation has a positive and significant effect on employee loyalty, and workload has a positive and significant effect on employee loyalty.
Photocatalytic degradation of tetracycline and ciprofloxacin antibiotic residues in aqueous phase by biosynthesized nZVI using Sal (Shorea robusta) leaf extract
Authors: Jha Aditya Kumar , Chakraborty Sukalyan
Published: February 2023

Conventional treatments for antibiotic residues in effluents are inefficient and do not lead to complete removal. Though effective and feasible degradation of antibiotics using nanoparticles has been reported by several scientists, chemically synthesized nanoparticles have their own disadvantages. Thus, in this study, nZVI was biosynthesized using leaf extract of Shorea robusta and precursor FeSO4·7H2O for photocatalytically degrading tetracycline (TC) and ciprofloxacin (CIP). The characterization of nZVI was performed using SEM, TEM, AFM, EDX, FTIR, and XRD to test their properties, which revealed iron-rich, well-dispersed, spherical, crystalline nanoparticles. Photocatalytic degradation of TC and CIP under UV illumination revealed 88 and 84% optimum efficiency at antibiotic concentrations 15 and 25 mg L−1, 0.014 and 0.0175 g L−1 doses of nZVI, respectively in the pH range 4–6 in 70 min. The degradation was further verified using mass spectrometry, which confirmed the degradation of antibiotics into the breakdown products. Toxicity assay of the degraded antibiotic solution proved it non-toxic for bacteria and safe for discharge into water bodies. The cost analysis of antibiotic degradation using nZVI proved very economical, costing around 1.5 USD per 1,000 L of wastewater.
Application of multivariate statistical methods to enhance the water quality monitoring system of Kashmir Valley with special emphasis on side-stream pollution
Authors: Gull Sarvat , Shah Shagoofta Rasool , Dar Ayaz Mohmood
Published: February 2023

Surface waterbodies, on which the growing population of Kashmir Valley is reliant in a variety of ways, are increasingly deteriorated due to anthropogenic pollution from rapid economic development. This research aims to assess the quality of the surface waterbodies in the north-eastern region of Kashmir Valley. Standard analytical procedures were used to analyze the water samples taken from 11 distinct sampling stations for 14 physicochemical parameters. The results were compared with the standard permissible levels which showed that the water quality of rivers and lakes in the north-east Himalayan region has steadily declined. Furthermore, multivariate statistical techniques were used with the goal of identifying key variables that influence seasonal and sectional water quality variations. The analysis of variance (ANOVA) analysis revealed that there is substantial spatio-temporal variability in the water quality parameters. According to principal component analysis (PCA) results, four primary components, which together accounted for 79.23% of the total variance, could be used to evaluate all data. Chemical, organic, and conventional pollutants were found to be significant latent factors influencing the water quality of rivers in the study region. The results indicate that PCA and ANOVA may be used as vital tools to identify crucial surface water quality indices and the most contaminated river sections.
Pipe and isolation valve failure-impact analysis and prioritization model for an urban water distribution network
Authors: Beker Bahar Adem , Kansal Mitthan Lal
Published: February 2023

Pipe and isolation valve failure in an urban water distribution network (WDN) causes service interruption to the water users. It is important to identify and prioritize the maintenance of the most severe impact-causing pipes and valve failures. This study investigates the impacts of such failures in terms of the number of isolation elements, the number of affected customers, and the supply shortfall (SS). The study proposes an impact-based prioritization model for pipe and isolation valve repair/replacement in a WDN using the analytic hierarchy process (AHP). The WDN modeling, simulation, and generation of segments are carried out using the WaterGEMS software. The proposed methodology is illustrated with the help of a real-time WDN of Dire Dawa city in Ethiopia. Through the study, it is noticed that each valve/pipe failure has varied impacts and gets reduced with the increase in valve density. Further, the supply shortfall is the most important parameter for prioritizing the maintenance. The failure of the valves and pipes significantly affects the system's performance and should be repaired/replaced on priority basis. It is hoped that the proposal will help the decision-makers in the optimal utilization of limited resources available for repair/ maintenance.
Green synthesis of granular activated carbon/zinc ferro nanocomposites-based bioleached laterite iron (BLaFe) for the removal of Rhodamine B in water using adsorption–Fenton's oxidation process
Authors: S. Bhaskar , K. N. Rashmishree , B. Manu , Sreenivasa M. Y.
Published: February 2023

Novel cost-effective catalyst granular activated carbon (GAC)-based zinc ferro nanocomposites for the heterogeneous Fenton's oxidation of dye were synthesized using bioleached laterite iron (BLFe) as a precursor and Psidium gujava leaf extract. Synthesized nanocomposites were characterized using SEM, EDS, XRD and BET surface area analysis. The degradation of Rhodamine dye was carried out with nanocomposites using adsorption–Fenton's oxidation process. The catalytic role of nanocomposites in Fenton's oxidation of Rhodamine B (RhB) was investigated and reported. The maximum dye removal of 96.2% was observed with 64.2% COD removal within 200 min of treatment. An increase in nanocomposite dosage has a positive effect on dye removal marking 5 g/L as an optimum dosage. Adsorption studies reveal that RhB removal using BLFe-based GAC/zinc ferro composites fits the Freundlich Adsorption Isotherm model with an adsorption capacity of 47.81 mg/g. A combination of adsorption and Fenton's oxidation has resulted in higher removal efficiency with nanocomposite material. Reusability studies confirm that the spent catalyst can be reused for five cycles.
MARKETING VERDE Y BENCHMARKING AMBIENTAL COMO INSTRUMENTOS DE BIOPOLÍTICA
Authors: Doca Heloisa Helou , Dias Jefferson Aparecido , Nobre Julia Macedo Nogueira
Published: February 2023

Este artículo está dedicado a analizar la definición y la importancia del marketing ecológico y lo benchmarking ambiental, además de verificar la relación entre estos términos y la biopolítica. Tal trabajo se justifica en vista de la creciente preocupación por el medio ambiente, los preceptos constitucionales de la función social y solidaria y la necesidad de garantizar la preservación del medio ambiente para las generaciones presentes y futuras. Desde el método deductivo, con el uso de la investigación bibliográfica, se observó que el marketing verde es una herramienta importante para que la empresa revele lo que ha hecho a favor del medio ambiente y el benchmarking ambiental es responsable de difundir y fomentar el conocimiento en área ambiental, ya que promueve un análisis comparativo de las acciones de protección ambiental llevadas a cabo entre empresas de la misma industria. También se hizo evidente que tanto el marketing ecológico como lo benchmarking son instrumentos importantes de la biopolítica, ya que son el resultado de los mecanismos de control y la emancipación de la sociedad, cuyo objetivo es ser activo en el proceso de toma de decisiones que tiene como objetivo mantener el ambiente ecológicamente equilibrado para las generaciones presentes y futuras, además de cumplir con su función social y solidaria.
AO LADO DE QUEM ESTAMOS NA AMÉRICA LATINA? O ISOLAMENTO DO BRASIL NA MANUTENÇÃO DO CRIME DE DESACATO
Authors: Catib de Laurentiis Lucas , Conci Luiz Guilherme Arcaro
Published: February 2023

O presente artigo objetiva demonstrar em que sentido caminharam os estados nacionais, na América Latina, desde a década de 1990, que coincide com a consolidação do processo de redemocratização na região, no sentido de abolirem tipos penais de desacato. Consolida a percepção de que em ordens democráticas, o tratamento especial dado em âmbito penal aos funcionários públicos, limitando a liberdade de expressão no que diz respeito à crítica pública por parte das pessoas, não se coaduna com a ordem estabelecida por Estados Democráticos e de Direito. Mostra que, ao lado de El Salvador e Venezuela, o Brasil se isolou na tipificação ou na manutenção do desacato como crime. Para tanto, utiliza-se de elementos próprios do constitucionalismo latino-americano e da doutrina do Ius Constitutionale Commune como estratégia para a análise comparada, buscando alcançar algum padrão regional a transformação de ordens jurídicas em processos de consolidação de democracias.
A META 5.5 DA AGENDA 2030 E A INTER-RELAÇÃO ENTRE DESIGUALDADES SOCIAIS PARA A PARIDADE POLÍTICA FEMININA NO BRASIL
Authors: Martins Amaral Ana Paula , Silva Peixoto Emini
Published: February 2023

O presente estudo busca analisar em medida as desigualdades sociais, econômicas e culturais interferem diretamente no empoderamento político da mulher e no alcance da igualdade entre gêneros em ambientes públicos decisórios no atual cenário social brasileiro, e, por consequência, obstaculizam o cumprimento da meta 5.5 do ODS-5 da Agenda de Desenvolvimento Sustentável da ONU. A partir do princípio de paridade de participação, descrito por Nancy Fraser, avalia-se os diversos aspectos das desigualdades brasileiras entre homens e mulheres e o progresso da paridade de gêneros nacional. Analisando-se o desenvolvimento das Agendas Globais da ONU, e as disparidades sociais, acentuadas logo após a globalização, conclui-se que as desigualdades econômicas, sociais e culturais, construídas a partir da herança patriarcal histórica brasileira, influenciam diretamente no âmbito político, obstando, de forma direta o ingresso feminino nos ambientes públicos de poder, e, por consequente, o cumprimento do ODS-5, e sua meta 5.5, o que se verifica a partir dos dados da presença ínfima da mulher na política, no percentual de apenas 15% em cada casa legislativa e sua irrisória participação em outros cenários públicos decisórios.
DESAFIOS DO ESTADO SOCIAL PERANTE O NEOLIBERALISMO E ALTERNATIVAS POLÍTICAS PARA A REDUÇÃO DAS DESIGUALDADES
Authors: Rovani de Linhares Rafaela , Aparecida Gervasoni Tássia
Published: February 2023

A pesquisa objetiva analisar os desafios do Estado Social perante o neoliberalismo e algumas alternativas políticas para a redução das desigualdades, por meio da análise de dados mapeados anteriormente e durante a pandemia Covid-19. Para tanto, o problema de pesquisa que se apresenta é: como o neoliberalismo produz e acentua desigualdades e, perante isso, quais os desafios do Estado Social e quais as alternativas políticas para a redução dessas desigualdades? No decorrer do estudo, foi utilizado o método de abordagem dedutivo e, como método de procedimento, adotou-se o monográfico, pela técnica de pesquisa bibliográfica. Ao final, foi possível evidenciar que as forças neoliberais, conduzidas pelos interesses da elite econômica, são capazes tanto de produzir como acentuar desigualdades. Ademais, tendo em conta as disparidades escancaradas pela pandemia e contemplando algumas medidas de enfrentamento, as possibilidades apontadas pela pesquisa apresentam-se como importantes medidas para lançar novas perspectivas à redução dessas desigualdades e fortalecer a democracia dos países, no contexto da justiça social e da cidadania.
A AUTORIZAÇÃO PRÉVIA E EXPRESSA PARA PAGAMENTO DE CONTRIBUIÇÃO SINDICAL PREVISTA NA LEI Nº 13.467/2017
Authors: Iara Marthos Águila  , Lislene Ledier Aylon
Published: February 2023

A Lei nº 13.467/2017, conhecida como Reforma Trabalhista, trouxe várias modificações legislativas na Consolidação das Leis do Trabalho (CLT), e mais do que alteração legal a nova lei impactou modelos e passa a exigir novas posturas das partes envolvidas nas relações de trabalho. Dentre as diversas modificações está a supressão da compulsoriedade da contribuição sindical, que, portanto, deixou de ser obrigatória e passou a ser facultativa, cujo pagamento está condicionado à prévia e expressa autorização dos que participarem de uma determinada categoria econômica ou profissional, ou de uma profissão liberal. Muito se discutiu sobre a constitucionalidade da alteração legal, contudo, o Supremo Tribunal Federal (STF) declarou constitucional a mudança. A partir de então, entidades sindicais e outras entidades passaram a defender a possibilidade da autorização prévia e expressa ser coletiva e não individual. O presente artigo tem o objetivo de analisar a questão do ponto de vista jurídico e manifestar a impossibilidade da substituição da autorização individual por coletiva.
Synthesis and Biological Activities of Heterocyclic Hybrids Containing
Piperidine and Pyridine Moieties: Recent Developments
Authors: Pemawat Gangotri , Bhatnagar Ayushi , Khangarot Rama Kanwar
Published: February 2023

Piperidine and pyridine nuclei are essential heterocyclic systems and act as an essential underpinning
for agriculture, medicines, industries, etc. The development of novel methods for the synthesis
of these exemplary heterocyclic compounds and their respective hybrids, which show a wide
range of biological activities, is a very fascinating theme. The derivatives of these pervasive nuclei are
used as antibacterial, antimicrobial, antifungal, antimalarial, anticancer, antiproliferative, antihypertensive,
antiparasitic, and many other agents. The hybrids of these nuclei have retained a distinct position
in medicinal chemistry and are often incorporated in synthetic drug discovery. In this review, we
have compiled relevant literature on different derivatives of piperidine and pyridine moieties and their
biological activities.
Rectal Bleeding in Infants: Diagnostic Work-up and Management
Authors: Quitadamo Paolo , Isoldi Sara , Mallardo Saverio , Zenzeri Letizia , Ceccanti Silvia , Battagliere Ilaria , Del Bene Margherita , Di Nardo Giovanni
Published: February 2023

Lower gastrointestinal bleeding is an alarming symptom in pediatrics, especially in in-
fancy. However, it is commonly secondary to benign and self-limiting conditions, such as anal fis-
sures, infections, and allergies; more rarely it is caused by more serious disorders, such as necrotiz-
ing enterocolitis, very early onset inflammatory bowel diseases, and vascular malformations.
The present review aims at summarizing the different clinical conditions presenting with rectal
bleeding in infancy and provides an evidence-based diagnostic work-up for the clinical management
of patients with this occurrence.
Review on Multifunctional Nanotherapeutics for Drug Delivery, Tumor
Imaging, and Selective Tumor Targeting by Hyaluronic Acid Coupled
Graphene Quantum Dots
Authors: Morani Dilip O. , Patil Pravin O.
Published: February 2023

Cancer is one of the most widespread life-threatening diseases, and among different
types of cancers, breast cancer is the major disease affecting many women worldwide.

Background:

Conventional chemotherapy using anticancer drugs has many drawbacks, like
poor water solubility, poor bioavailability, rapid relapse, non-specific selectivity, effect on normal
tissues, and rapid drug resistance. Thus, over the last few years, immense efforts have been
made to fabricate nanotherapeutics that will release drugs in response to stimuli.

Objective:

Nanotherapeutics based on graphene quantum dots have been acknowledged with
much gratitude in the bioscience field and investigation applications because of their distinguishing
chemical and physical properties, such as medicine delivery, biosensors, and bioimaging for
the advancement invention of disease.

Conclusion:

This paper analyzes the potential applications of graphene quantum dots for the
modified and desired release of antitumor drugs. Also, it shows graphene quantum dots' capability
to functionalize in the companionship of hyaluronic acid that operates regarding cancer cell
directing matrix in bioimaging and multimodal therapy.
Development and Evaluation of a Novel Hyaluronic Acid and
Chitosan-modified Phytosome for Co-delivery of Oxymatrine and
Glycyrrhizin for Combination Therapy
Authors: Chen Xiaojin , Yu Shuying , Wang Pingping , Zhao XinFeng , Sang Gao
Published: February 2023

Background:

Multidrug resistance (MDR) of cancer cells is a major obstacle to efficient
cancer chemotherapy. Combination therapy is expected to enhance the anticancer effect and
reverse MDR. Numerous patents involve different kinds of nanoparticles for the co-delivery of
multiple chemotherapeutics, but the FDA has approved none.

Objective:

In this study, oxymatrine (OMT) and glycyrrhizin (GL) were co-loaded into phytosomes
as the core of nanocarriers, and the shell was cross-linked with chitosan (CS) and hyaluronic
acid (HA) with the capability for the controlled, sequential release and the targeted drug uptake

Methods:

Phospholipid complexes of OMT and GL (OGPs) were prepared by a solvent evaporation
technique and could self-assemble in an aqueous solution to form phytosomes. CS and HA
were sequentially coated on the surface of OGPs via electrostatic interactions to obtain CS coated
OGPs (CS-OGPs) and HA modified CS-OGPs (HA-CS-OGPs), respectively. The particle size and
zeta potential were measured to optimize the formulations. In vitro cytotoxicity and cellular uptake
experiments on HepG2 cells were performed to evaluate the anticancer activity.

Results:

OGPs were obtained with nano-size around 100 nm, and CS and HA coating on phytosomes
could change the particle size and surface potential. The drug loading of OMT and GL
showed that the nanocarriers could maintain a fixed ratio of 1:1. The in vitro release experiments
indicated the release of OMT and GL was pH-dependent and sequential: the release of OMT from
CS-OGPs and HA-CS-OGPs was significantly increased at pH 5.0 compared to the release at pH
7.4, while GL exhibited sustained released from CS-OGPs and HA-CS-OGPs at pH 5.0. Furthermore,
in vitro cytotoxicity and cellular uptake experiments on HepG2 cells demonstrated that the
co-delivery system based on phytosomes had significant synergistic anti-tumor activities, and the
effects were enhanced by CS and HA modification.

Conclusion:

The delivery of OMT and GL via HA-CS-OGPs might be a promising treatment to
reverse MDR in cancer therapy.
Recent Patents on Manufacturing Microtextured Surface
Authors: Pan Chengyi , Yan Yubin , Cao Yuanfei , Shao Ruinan
Published: February 2023

Background:

Surface microtextured technology is an expansion and extension of biomimicry
in the tribology field, promoting vigorous development in microtextured tribology.
Through artificial means, tiny convex hulls, craters, or stripes of specific size and arrangement are
processed on the friction surfaces to change the morphology and contact angle of the surfaces and
improve the surface contact state or the lubrication effect. The function and properties of microtextured
surfaces are determined by optimizing their geometrical parameters, but the microtextured
geometrical parameters require a high-level machining quality. It is necessary to analyze and summarize
the existing research on manufacturing microtextured surfaces. By summarizing the preparation
methods of microtextured surfaces in the past decade, some valuable conclusions are drawn to
predict the future development of technology for manufacturing microtextured surfaces and provide
a reference for researchers in related fields. This paper summarizes the representative patents related
to the methods of manufacturing microtextured surfaces, analyzes the properties of the microtextured
surfaces produced by each method, and discusses the advantages and disadvantages of these
methods. The existing problems are summarised through the analyses of patents related to microtextured
preparation methods. The future development of new preparation methods has prospected. By
cooperating with various processing technologies and optimizing the processing methods, the microtextured
surfaces can meet various functional requirements, and the manufacturing precision is
higher than before. The processing method needs further improvement according to the working
conditions. More new technologies will be invented to create microtextured surfaces.
Research on CMUTs Design with Different Cell Arrangements
Authors: Cao Xuewen , Yu Yuanyu , Liu Xin , Ma Jingyi , Zhang Hua , Wang Lijia
Published: February 2023

Background:

Capacitive micromachined ultrasonic transducers (CMUTs) is a promising
component of mechanical-electrical-acoustical conversion, which shows valuable applications in
non-distructive testing and obstacle detection fields. In order to study the influence of dimension
parameters on the directivity of CMUTs, the three-dimensional multi-physics coupling model is
proposed for CMUTs in this paper.

Methods:

The model combines multiple physical fields through finite element method (FEM),
which is more efficient and accurate. The influence of dimension parameters on the transducer is
studied from two aspects: the pitch between adjacent cells and cell number, respectively.

Results:

When increasing the pitch, the directivity becomes better if the pitch is less than half of the
wavelength, the grating lobe and side lobe are aroused. However, the bandwidth at -3dB is reduced
by up to 71.1% at the same time. When increasing the cell number, the better the direcitvity, while
the change of the cell number has little effect on the bandwidth of the array. However, 5.4% frequency
shift was caused due to the effective mass change of the transducer.

Conclusion:

In this study, a 3D model based on FEM is proposed for the influence of dimension
parameter on CMUTs. The simulation results indicate that the directivity can be enhanced by changing
the dimension. At the same time, it also introduces other performance issues, such as bandwidth
decrease and frequency shift through this approach. Therefore, the simulation proposed the guidance
of CMUTs performance optimization and patented technology application work in the future.
Greener Approaches for Synthesis of Bioactive Thiadiazole Scaffolds
Authors: Sahoo Biswa Mohan , Banik Bimal Krishna , Tiwari Abhishek , Tiwari Varsha , Mahapatra Manoj Kumar
Published: February 2023

Thiadiazole is a paradigm of five membered heterocyclic compound that contains two
nitrogens and one sulphur as heteroatoms with molecular formula C2H2N2S. Thiadiazole is mainly
present in four isomeric forms such as 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole and
1,3,4-thiadiazole. Out of these isomers, 1,3,4-thiadiazole has attracted remarkable attention in the
field of medicinal chemistry. Some of the drugs containing 1,3,4-thiadiazole moiety are used clinically
and are available in the market including Sulphamethizole (Antibacterial), Acetazolamide
(Diuretic), Azetepa (Antineoplastic), Cefazolin (Antibiotic), Megazol (Antiprotozoal), Atibeprone
(anti-depressant). Several greener approaches are applied for the synthesis of thiadiazole scaffolds
including microwave irradiation, ultrasonic irradiation, grinding, ball milling technique, etc. These
methods are eco-friendly, nonhazardous, reproducible, and economical approach. Based on these
Green chemistry approaches, thiadiazole derivatives are synthesized from thiosemicarbazide. The
functionalization of these heterocyclic compounds generates thiadiazole derivatives with diverse
chemical structures. This review covers green synthesis, biological potentials, and structure activity
relationship study of thiadiazole analogs.
Cardioprotective Activities of some Indian Spices: An Insight into
Pharmacology and Phytochemical Investigation
Authors: Pathak Kalyani , Pathak Manash Pratim , Saikia Riya , Gogoi Urvashee , Sahariah Jon Jyoti , Das Aparoop , Ahmad Mohammad Zaki , Paul Tirna , Das Jyotirmoy , Alqahtani Saif Aboud M.
Published: February 2023

Cardiovascular disease (CVD) is the leading cause of death globally, and coronary heart
disease (CHD) is the most prominent one among the spectrum of CVD. Conventional CHD drugs
pose an increased risk of pharmaceutical interactions. Moreover, the possibility of tainting or substituting
other medications also raises concerns. Diet and lifestyle play an important role in preventing
and treating heart disease, and certain spices and supplements can help reduce the risk of heart disease
and treat it. Spices have been an important part of Indian culture from the dawn of time, valued
for both their culinary and medicinal virtues. Indian spices and their bioactive phytoconstituents are
reported to play an ameliorating role in treating CHD. Despite the fact that the majority of these
spices have an effect on organic components associated with the cardiovascular system, data on
their therapeutic effects is sparse. To make the most of the enormous potential of these spices, multidisciplinary
research is the need of the hour to establish them as remedies for CVDs. We endeavour
to document some ethnopharmacological studies aimed to establish the cellular and molecular
cardio-protective mechanisms of the spices and their bioactive phytoconstituents using recently reported
in vitro and in vivo studies. Finally, we reviewed and reported the results of the recent clinical
trials that have been conducted using these spices with special emphasis on their efficacy, safety,
and toxicity.
Охлаждение парогазовой смеси испаряющимися каплями воды: зависимость времени охлаждения от начальной температуры парогазовой смеси
Authors: Корценштейн Н.М.
Published: February 2023

Numerical modeling of the cooling of a vapor-gas mixture by evaporating water drops has been carried out. An expression is proposed using the characteristic temperature, which determines the dependence of the cooling time on the initial temperature of the mixture. A technique for determining the characteristic temperature based on the results of numerical simulation is presented. An estimate of the error in the results of using the obtained expressions is made.
Особенности макроскопического транспорта зарядов в ансамблях плотноупакованных наночастиц анатаза вблизи порога протекания
Authors: Зимняков Д.А. , Волчков С.С. , Варежников А.С. , Васильков М.Ю. , Плугин И.А.
Published: February 2023

The results of experimental studies of the effect of degradation of macroscopic charge transport in ensembles of close-packed anatase nanoparticles under long-term action of a constant electric field are presented. The degradation is presumably due to the increasing degree of blocking of statistically independent conduction channels formed in ensembles of particles under the field action. A phenomenological model is considered for estimating the number of active conduction channels in an ensemble of particles near the percolation threshold in the system.
Структура зоны контакта наплавка-подложка, подвергнутой электронно-пучковой обработке
Authors: Иванов Ю.Ф. , Громов В.Е. , Ефимов М.О. , Шлярова Ю.А. , Панченко И.А. , Коновалов С.В.
Published: February 2023

Using scanning and transmission electron microscopy, the analysis of the structure, phase and elemental composition of the contact zone of the system coating (high-entropy FeCrCoNiMn alloy)-substrate (5083 alloy) after electron-beam processing was performed. The formation of a multiphase, multielement submicro- and nanocrystalline structure has been established. The structure of high-speed cellular crystallization in the contact layers adjacent to the coating and substrate is revealed, and the formation of lamellar crystals in the central region of the contact zone is also found. Keywords: contact zone, high-entropy alloy, wire-arc additive manufacturing method, 5083 aluminum alloy, pulsed electron beam, elemental and phase composition, structure.
This is test MS 15 FEb (Preprint)
Authors: Account Developer
Published: February 2023

UNSTRUCTURED

This is test MS 15 FEb
Internet-Based Recruitment and Retention of Young Adults With Type 1 Diabetes: Cross-Sectional Study (Preprint)
Authors: Griggs Stephanie , Ash Garrett I , Pignatiello Grant , Papik AnnMarie , Huynh Johnathan , Leuchtag Mary , Hickman Jr Ronald L
Published: February 2023

BACKGROUND

Multiple research strategies are required to recruit and engage a representative cohort of young adults in diabetes research. In this report, we describe an approach for internet-based recruitment for a repeated-measures descriptive study.

OBJECTIVE

The objective of this cross-sectional study was to determine whether internet-based recruitment through multiple social media platforms, a clinical research platform, and cooperation with community partnerships—College Diabetes Network and Beyond Type 1—would serve as an effective way to recruit a representative sample of young adults aged 18-25 years with type 1 diabetes (T1D).

METHODS

We conducted a repeated-measures descriptive study. We captured enrollment rates and participant characteristics acquired from each social media platform through survey data and Facebook analytics. This study was advertised via paid postings across a combination of different social media platforms (eg, Facebook, Instagram, Twitter, and Reddit). We used quarterly application postings, quarterly newsletters, and participation in the ResearchMatch registry to identify potentially eligible participants from February 3, 2021, to June 6, 2022.

RESULTS

ResearchMatch proved to be the most cost-effective strategy overall, yielding the highest gender and racial diversity compared to other internet platforms (eg, Facebook, Instagram, Twitter, and Reddit), application postings (eg, Beyond Type 1), and newsletters (eg, College Diabetes Network and a local area college). However, we propose that the combination of these approaches yielded a larger, more diverse sample compared to any individual strategy. Our recruitment cost was US $16.69 per eligible participant, with a 1.27% conversion rate and a 30% eligibility rate.

CONCLUSIONS

Recruiting young adults with T1D across multiple internet-based platforms was an effective strategy to yield a moderately diverse sample. Leveraging various recruitment strategies is necessary to produce a representative sample of young adults with T1D. As the internet becomes a larger forum for study recruitment, participants from underrepresented backgrounds may continue engaging in research through advertisements on the internet and other internet-based recruitment platforms.
Menjangkau Sasaran melalui Sosial Media: Inovasi Edukasi Kesehatan Masyarakat di Era Pandemik Covid-19
Authors: Supriyati Supriyati , Putri Nindi Deshira , Darmawan Kevin , Suaidah Riski , Yudhistira Pramudhita , Ismandhani Ahmad Kevin , Permatasari Endah Amalia
Published: February 2023

Globally, health literacy on the Covid-19 is poor and underestimated. The intensive health education will improve the health literacy on the Covid-19 and important to control and prevent the Covid-19. The health protocol suggest that everyone should apply the physical distancing. Thus, the health education through social media was applied to reach the target audiences for improving the health literacy on the Covid-19. Instagram was chosen as the communication chanell for the program that targeted to youth. This program had been done in March 2020 which targeted to the Indonesian youth people who access internet and Instagram. The health message was developed based on the newest version of the Covid-19 control guidance that issued by the Ministry of Health Republic Indonesia. There were more than 3.500 people viewed the message on the Instagram, and part of them gave positive response and tried to send the message forward to their social network. This program indicated that Instagram was became the alternative communication channel to increase health literacy on the Covid-19, especially for youth.
Pengenalan dan Pelatihan Pengendalian Secara Hayati Larva Nyamuk dengan Bacillus thuringensis var. israelensis Kultur Air Kelapa di Desa Kedungpoh, Kecamatan Nglipar, Kabupaten Gunungkidul
Authors: Kinanti Thiwuk Leres , Sumarmi Siti , Kusumawati Nafisa , Putri Ristiyani Khofifa , Adi Hanindyo , Marsudi Tri
Published: February 2023

Kegiatan hibah pengabdian kepada masyarakat merdeka kampus merdeka (PKM-MBKM) dilakukan dengan melaksanakan pengenalan dan pengendalian larva nyamuk vektor penyakit dengan menggunakan Bacillus thuringiensis var israelensis (Bti.) yang dibiakkan pada air kelapa di Desa Kedungpoh , Kecamatan Nglipar, Kabupaten Gunung Kidul. Kegiatan pengabdian masyarakat ini diharapkan memberikan informasi cara pengendalian nyamuk secara biologi yang efektif, mudah dan murah. Metode pengaplikasian agen hayati Bti. dilapang adalah dengan melalui pelatihan pembuatan kultur Bti.  dan uji efektifitas. Uji efektifitas Bti. kultur air kelapa dengan konsentrasi 0 ppm, 1 ppm, 1,5 ppm dan 2 ppm masing-masing diletakkan di luar dan di dalam rumah warga. Kegiatan monitoring efektifitas Bti. dilakukan melalui jumlah larva yang ada di dalam setiap ember perlakuan pada minggu ke 1, 2, 3. Kegiatan indentifikasi nyamuk dilakukan pada fase imago. Pelatihan diikuti oleh ibu-ibu kader kesehatan (Jumantik). Hasil monitoring menunjukkan bahwa menunjukkan bahwa aplikasi Bti. lebih efektif dalam mengendalikan larva nyamuk pada minggu ke-1 dibandingkan minggu ke-2 dan ke-3. Hasil identifikasi nyamuk yang diperoleh dari sampel menunjukan nyamuk Aedes sp., Culex sp., dan Armigers sp.
Keterlekatan Etika Moral Islam dan Budaya Jawa Petani Kopi Arjuno
Authors: Novianto Putra Ronny Ersya , Wicaksono Harianto , Rahmawati Desy Ayu Nining Dwi
Published: February 2023

Penelitian ini bertujuan untuk: (a) menggambarkan tipologi nilai etika moral Islam dan Jawa pada tindakan ekonomi petani kopi Arjuno, (b) menggambarkan pembentukan jaringan, relasi ekonomi, nilai, norma dan tindakan ekonomi individu petani kopi Arjuno dan, (c) keterlekatan etika moral  ekonomi Islam dan Jawa dalam  tindakan ekonomi petani kopi Arjuno. Penelitian ini menggunakan kualitatif sebagai metode penelitian dengan pendekatan studi kasus, latar tempat dalam penelitian ini perkebunan kopi rakyat lereng gunung Arjuno. Hasil penelitian ini menunjukkan: (a) petani kapitalis Islam dan Jawa memegang teguh tipologi nilai dasar manusia Jawa, nilai “Gak Gelem di ndas-endasi”, petani kopi kapitalis Islam membentuk nilai adil, sabar dan jujur dalam mempertahankan eksistensinya, sementara petani kopi kapitalis Jawa membentuk nilai nerimo ing pandum, eling lan waspodo serta tepo sliro, prasojo lan temen untuk mempertahankan eksistensinya. (b) jaringan dan hubungan ekonomi yang terbentuk intens menguatkan trust antar aktor serta nilai, norma dan tindakan ekonomi  individu petani kopi Arjuno bersifat kolektif dan inklusif. (c) keterlekatan etika moral ekonomi Islam dan Jawa dalam tindakan ekonomi petani kopi Arjuno, petani kopi kapitalis Islam mampu berkembang dan membuka tindakan ekonomi bersifat kolaboratif aktif dalam mempertahankan eksistensinya, berbanding terbalik dengan petani kopi kapitalis Jawa.