bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concern
Authors: Graham Carl , Lechmere Thomas , Rehman Aisha , Seow Jeffrey , Kurshan Ashwini , Huettner Isabella , Maguire Thomas J. A. , Tam Jerry C. H. , Cox Daniel , Ward Christopher , Racz Mariusz , Waters Anele , Mant Christine , Malim Michael H. , Fox Julie , Doores Katie J.
Published: October 2022

COVID-19 vaccines are playing a vital role in controlling the COVID-19 pandemic. As SARS-CoV-2 variants encoding mutations in the surface glycoprotein, Spike, continue to emerge, there is increased need to identify immunogens and vaccination regimens that provide the broadest and most durable immune responses. We compared the magnitude and breadth of the neutralizing antibody response, as well as levels of Spike-reactive memory B cells, in individuals receiving a second dose of BNT162b2 at a short (3–4 week) or extended interval (8–12 weeks) and following a third vaccination approximately 6–8 months later. We show that whilst an extended interval between the first two vaccinations can greatly increase the breadth of the immune response and generate a higher proportion of Spike reactive memory B cells, a third vaccination leads to similar levels between the two groups. Furthermore, we show that the third vaccine dose enhances neutralization activity against omicron lineage members BA.1, BA.2 and BA.4/BA.5 and this is further increased following breakthrough infection during the UK omicron wave. These findings are relevant for vaccination strategies in populations where COVID-19 vaccine coverage remains low.
Requirement of a functional ion channel for Sindbis virus glycoprotein transport, CPV-II formation, and efficient virus budding
Authors: Elmasri Zeinab , Negi Vashi , Kuhn Richard J. , Jose Joyce
Published: October 2022

Many viruses encode ion channel proteins that oligomerize to form hydrophilic pores in membranes of virus-infected cells and the viral membrane in some enveloped viruses. Alphavirus 6K, human immunodeficiency virus type 1 Vpu (HIV-Vpu), influenza A virus M2 (IAV-M2), and hepatitis C virus P7 (HCV-P7) are transmembrane ion channel proteins that play essential roles in virus assembly, budding, and entry. While the oligomeric structures and mechanisms of ion channel activity are well-established for M2 and P7, these remain unknown for 6K. Here we investigated the functional role of the ion channel activity of 6K in alphavirus assembly by utilizing a series of Sindbis virus (SINV) ion channel chimeras expressing the ion channel helix from Vpu or M2 or substituting the entire 6K protein with full-length P7, in cis. We demonstrate that the Vpu helix efficiently complements 6K, whereas M2 and P7 are less efficient. Our results indicate that while SINV is primarily insensitive to the M2 ion channel inhibitor amantadine, the Vpu inhibitor 5-N, N-Hexamethylene amiloride (HMA), significantly reduces SINV release, suggesting that the ion channel activity of 6K similar to Vpu, promotes virus budding. Using live-cell imaging of SINV with a miniSOG-tagged 6K and mCherry-tagged E2, we further demonstrate that 6K and E2 colocalize with the Golgi apparatus in the secretory pathway. To contextualize the localization of 6K in the Golgi, we analyzed cells infected with SINV and SINV-ion channel chimeras using transmission electron microscopy. Our results provide evidence for the first time for the functional role of 6K in type II cytopathic vacuoles (CPV-II) formation. We demonstrate that in the absence of 6K, CPV-II, which originates from the Golgi apparatus, is not detected in infected cells, with a concomitant reduction in the glycoprotein transport to the plasma membrane. Substituting a functional ion channel, M2 or Vpu localizing to Golgi, restores CPV-II production, whereas P7, retained in the ER, is inadequate to induce CPV-II formation. Altogether our results indicate that ion channel activity of 6K is required for the formation of CPV-II from the Golgi apparatus, promoting glycoprotein spike transport to the plasma membrane and efficient virus budding.
Habitar las rajaduras: auto-etnografías y narrativas de la identidad en G. Anzaldúa y A. Lorde
Authors: Meloni González Carolina
Published: October 2022

Encontramos en la obra de Gloria Anzaldúa y Audre Lorde toda una narrativa sobre la identidad desde dos ejes fundamentales: por una parte, ambas llevan a cabo una suerte de auto-etnografía y viaje interior a través de la propia escritura, en la que el lenguaje y las palabras se entremezclan con la vida, los miedos y la memoria de las autoras; por otra, dicha escritura es entendida como el lugar para sanar las heridas, transformando el silencio y las opresiones sufridas en verdadera alquimia del alma. Se trata de nombrar lo que no tiene nombre, de repolitizar la rabia, de situarnos en las rajaduras del trauma, ese que la expropiación más absoluta que el racismo, el patriarcado y la colonización pueden provocar. Este artículo aborda este proceso de auto-construcción del yo en ambas autoras, proceso que es entendido siempre como trabajo colectivo y como herramienta de transformación del mundo. Para ambas, la escritura se transforma en un compromiso ético-político, suerte de imperativo que atraviesa no solo la forma y el estilo de escribir y hacer teoría, sino también de encarnar en nuestras propias existencias una conciencia feminista.
Boris Groys Philosophical Conversations - Towards Self-Design
Authors: Groys Boris , Nabais Catarina Pombo
Published: October 2022

Esta obra foi concebida sob forma de sucessivas entrevistas, entre o autor, Boris Groys, e uma interlocutora, Catarina Pombo Nabais, ambos especialistas na área da Filosofia. Os temas das conversações suscitam questões de impacto no moderno pensamento ocidental, dialogando, de forma inovadora e autónoma, com conceitos estabelecidos.
Fecal Calprotectin and Quality of Life Questionnaires Are Responsive to Change in Pouch Disease Activity After Antibiotic Therapy: Results From a Prospective Clinical Trial
Authors: Ollech Jacob E. , Yanai Henit , Avni-Biron Irit , Snir Yifat , Banai Hagar , Barkan Revital , Godny Lihi , Wasserberg Nir , White Ian , Dotan Iris
Published: October 2022

INTRODUCTION:

Whether fecal calprotectin (FC) and quality of life (QoL) questionnaires reflect change in disease activity in patients with a J-pouch is unknown.

METHODS:

Patients with acute pouchitis were prospectively treated with a 2-week course of antibiotics. The full Pouchitis Disease Activity Index, FC, and QoL questionnaires were measured at baseline and after antibiotic therapy.

RESULTS:

Twenty patients were prospectively enrolled. After 2 weeks of antibiotic treatment, the Pouchitis Disease Activity Index decreased from a median of 9 to 5 (P = 0.007). FC decreased from a median of 661 ug/g to 294 ug/g (P = 0.02), and QoL questionnaires improved significantly.

DISCUSSION:

FC and QoL questionnaires reflect real-time changes in inflammatory pouch activity.
Caring and Criminalising
Authors:   John Hopkins University, Lingis Alphonso
Published: October 2022

In the United States, many schools hire police to patrol the grounds and more call upon police to arrest students for violation of school policies. Many of these will be incarcerated within the subsequent five years. The widespread adoption of surveillance cameras, zero tolerance, and police presence in schools has resulted in more students being criminalised. This reflective essay examines the ideology supporting this school-to-prison pipeline. What conception of justice has been responsible for mass incarceration? Why are surveillance cameras, police, and zero toler- ance taken to be effective? Why has rehabilitation given way to retribution? Why does the public accept the criminalisation of youth in schools?
Comparative Assessment of the Parameters of the Social Sphere of Municipalities of the Trans-Baikal Territory
Authors:   Economic Research Institute FEB RAS, Kovalchuk Lyudmila
Published: October 2022

Based on Rosstat data for, as of January 1, 2022, an assessment of social inequality in the level of provision of the population with social institutions in the context of municipalities located in the central and peripheral parts of the Trans-Baikal Territory was carried out. In the context of spatial differences in the geographical, historical, economic and infrastructural features of the development of cities and districts of the region, a hypothesis is being tested about a higher level of provision of social institutions of municipalities located in the central part of Transbaikalia, in contrast to its periphery. The comparison is carried out on the basis of the parameters of the security of the municipalities of the Central zone of the Trans-Baikal Territory, characterized by a relatively high level of homogeneity, the largest population and the area of the occupied territory, which, according to the author, form the average «reference» range of values. The results obtained in the context of the types of institutions and municipalities of the central and peripheral parts of the Trans-Baikal Territory did not confirm the hypothesis of a higher provision of social institutions of municipal districts, municipal and urban districts located in the Central Transbaikalia. Analysis of statistical indicators and estimates obtained indicates that those municipalities on the territory of which mining is carried out, enterprises of JSC Russian Railways and military units are located, have not only a comparable, but also often a higher level of provision with cultural, educational, health and sports institutions. The identified features of the formation of differences in the level of provision of social institutions between the central cities and the periphery in the context of municipalities of the Trans-Baikal Territory require consideration when developing mechanisms for smoothing inequality
The Thorny Path Eastwards: Breakthroughs Which Turn Into Dead-End
Authors:   Economic Research Institute FEB RAS, Minakir Pavel
Published: October 2022

The long period of the development of the Soviet and then the Russian Far East has demonstrated a striking pattern of repetitive periods of optimism and pessimism about the possibility of socio-economic development of the region, a pattern as striking as the regular repetition of tools and goals, efforts of the region itself and the national political and economic system in this field. The last decade has passed and is still passing under the sign of a new stage of state regulatory efforts for the development of the region. The next stage in summing up the results and determining the scope and structure of further efforts in this direction was the next VII Eastern Economic Forum in Vladivostok. It has been concluded that, as demonstrated once again at the forum, despite enormous administrative efforts, vigorous institutional reform, and mobilization of public finances, it has not been possible to achieve noticeable results in the field of transforming the quality of life and economy in the Far East for almost 10 years. It has been shown that it is possible to change the situation in the field of resource provision of correct goal-setting only after overcoming fundamental limitations, which primarily include the already mentioned problem of the territorial scale of the object of regulation and the recognition of the need for an ideological transition from growth management to quality change management
Russia’s Trade with East Asian Countries: Comparative Costs and Potential
Authors:   Economic Research Institute FEB RAS, Izotov Dmitriy
Published: October 2022

In this paper it’s demonstrated that over the past decade Russia has sought to diversify its economic ties in favour of East Asian countries as part of the strategy on ‘turning to the East’. Such ties accounted for almost one third of Russia’s foreign trade turnover by 2020. According to the estimates presented in the article, the negative impact of geopolitical factors on Russian foreign trade has affected most countries that border Russia. At the same time, proximity and the presence of a land border have generally had a positive effect on Russian foreign trade, which indicates the opportunity to redistribute the foreign trade flows towards Asia. An assessment of the intensity of Russia’s foreign trade with East Asian countries demonstrates the redundancy of barriers in bilateral interactions. These estimates indicate a greater intensity of trade between the Russian economy and China, as well as the presence of Russia’s significant potential for expanding trade in the case of ‘deep’ integration with East Asian countries by levelling excess costs: with China – by 84%; with Taiwan – by 86%; with the Republic of Korea – by 102%; with ASEAN countries – by 113%; with Japan – by 122%. Due to the higher share of the trade with China in Russia’s foreign trade, rapprochement with the Chinese economy will contribute to generating large volumes of trade turnover between Russia and the outside world. It has been shown in the paper that as Russia approaches the economies of East Asia, reciprocity should be taken into account when reducing bilateral barriers as it may directly affect the choice of Russian strategy for purposes related to increasing mutual trade
The Mediating Effect of Company Performance on the Relationship Between Capital Structure and Firm Value in Food and Beverage Industry
Authors: Ingracia Meliana , Wijayanto Andi , Saryadi Saryadi
Published: October 2022

In determining investment decisions, investors need to consider firm value which will describe the welfare that the company is able to provide. The purpose of this research is to prove whether or not there is a mediating effect of company performance on the effect of capital structure on fluctuations in firm value. The analytical technique used is linear regression analysis and Sobel test with the research sample being 18 food and beverage sub-sector companies listed on the Indonesia Stock Exchange (IDX) in 2016-2020. This research gives the result that the capital structure has a negative effect on changes in firm value and company performance. Changes in firm value are not partially affected by company performance. Simultaneously, capital structure and company performance significantly affect firm value. The results obtained prove that the effect of capital structure on firm value cannot be mediated by company performance.
Psychological Capital dan Career Commitment pada Karyawan Milenial Kantor Pusat Bank BRI
Authors: Faustina Anjani , Kusumastuti Retno
Published: October 2022

The millennial generation has the most significant number in the Indonesian labor market, the first technophile generation, and is highly productive. However, the millennial generation tends to focus on themselves and lacks commitment. Closely related to individual career development, career commitment is one of the main challenges in managing Human Resources (HR), especially in Bank BRI, which focuses on the millennial generation. Considering there is still no related research, especially in the banking sector in Indonesia, this study aims to analyze the effect of psychological capital on the career commitment of millennial employees through subjective well-being as mediation at the Bank BRI Headquarters. This study uses a quantitative approach with an explanatory type by distributing questionnaires to 150 millennial employees at the Bank BRI Headquarters. The results showed an influence of psychological capital on the career commitment of millennial employees through subjective well-being as mediation at the Bank BRI Headquarters. This study shows that millennial employees at Bank BRI tend to respond positively to matters related to their work and subjectively feel their well-being. Therefore, all of the company's support helped to increase the millennials employees' psychological capital and subjective well-being, which led to their high career commitment. Generasi milenial merupakan generasi yang mendominasi pasar kerja di Indonesia saat ini dan generasi pertama yang cakap berteknologi serta sangat produktif. Namun, generasi milenial cenderung berfokus pada dirinya sendiri dan kurang memiliki komitmen. Terkait erat dengan pengembangan karir individu, career commitment menjadi salah satu tantangan utama pengelolaan Sumber Daya Manusia (SDM), khususnya pada Bank BRI yang sedang berfokus pada generasi milenial. Mempertimbangkan belum adanya riset terkait, khususnya pada sektor perbankan di Indonesia, penelitian ini ditujukan untuk menganalisis pengaruh psychological capital terhadap career commitment karyawan milenial melalui subjective well-being sebagai mediasi di Kantor Pusat Bank BRI. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis eksplanatif dengan menyebarkan kuesioner kepada 150 karyawan milenial di Kantor Pusat Bank BRI. Hasil penelitian menunjukkan bahwa terdapat pengaruh psychological capital terhadap career commitment karyawan milenial melalui subjective well-being sebagai mediasi di kantor pusat Bank BRI. Penelitian ini menunjukkan bahwa karyawan milenial di Bank BRI cenderung merespons secara positif hal-hal terkait pekerjaannya dan secara subjektif merasakan kesejahteraan. Oleh karena itu, dukungan peningkatan psychological capital dan subjective well-being perusahaan mendorong terciptanya career commitment pada karyawan milenial.
Sobolev-Gaffney type inequalities for differential forms on sub-Riemannian contact manifolds with bounded geometry
Authors: Baldi Annalisa , Tesi Maria Carla , Tripaldi Francesca
Published: October 2022

In this article, we establish a Gaffney type inequality, in

W

ℓ
,
p

{W}^{\ell ,p}

-Sobolev spaces, for differential forms on sub-Riemannian contact manifolds without boundary, having bounded geometry (hence, in particular, we have in mind noncompact manifolds). Here,

p
∈

]

1
,
∞

[

p\in ]1,\infty {[}

and

ℓ
=
1
,
2

\ell =1,2

depending on the order of the differential form we are considering. The proof relies on the structure of the Rumin’s complex of differential forms in contact manifolds, on a Sobolev-Gaffney inequality proved by Baldi-Franchi in the setting of the Heisenberg groups and on some geometric properties that can be proved for sub-Riemannian contact manifolds with bounded geometry.
Novel quotes: Achilles Tatius and Heliodorus in Byzantine sacro-profane florilegia
Authors: D’Alconzo Nicolò
Published: October 2022

The quotes in the sacro-profane florilegia have so far been neglected as documents for the 9th-century readership of the Greek novels. This article uses the quotes as intertextual links to the originals and reconstructs the excerption: mapped back onto the novels, the quotes highlight the excerptors’ points of interest and the patterns that connect them. Excerption is thus fully understood as reading practice. The quotes were collected not only because they could provide wisdom when decontextualised, but also because they played a relevant role in the excerptors’ analysis and interpretation of the novels. The florilegia are therefore unique texts in revealing the experience of reading the novels in the 9thcentury.
Further useful Psalms
Authors: Zellmann-Rohrer Michael
Published: October 2022

An additional witness to the Byzantine tradition of application of Psalms for amuletic and other ritual purposes, conventionally termed “magical”, in a fifteenth-century codex on medicine and the occult sciences (Bologna, BU Ms. 3632), is edited and translated, and its place in the tradition is considered. Combined with another, indirect witness, references to analogous uses of the Psalms by Theodore Balsamon and Matthew Blastares, this evidence strengthens a recent suggestion of broad popularity for the practice in Byzantium.
Modeling spa destination choice for leveraging hydrogeothermal potentials in Serbia
Authors: Radin Marija Belij , Vujičić Miroslav D. , Todorović Nikola , Dragin Aleksandra S. , Stankov Uglješa , Mijatov Maja B.
Published: October 2022

Serbian spas, with their abundant geothermal springs and air qualities, are a significant natural resource for the country. Nowadays, tourism industry has become a predominant beneficiary attracting both leisure- and health-related visits. Nonetheless, the literature on current consumer behavior is devoid of a model that incorporates both motivating and constraining factors in the spa and wellness industry’s decision-making process. Serbia’s spa industry is still adjusting to the needs of the modern wellness visitor as a result of the country’s unique transitional path. The purpose of this study is to ascertain the role of incentive and restrictions in the destination selection process of spa visitors in Serbia, to gain insight into the development of wellness tourism in a particular sociocultural environment. The analytical hierarchy process was used to determine the relative relevance of the consumer behavior elements evaluated. The findings indicate that non-medical motivations are becoming more important, implying that demand is finally shifting toward the wellness idea, which was initially disrupted by the country’s delayed transformation. The findings have administrative ramifications, the most significant of which were price strategies and product diversification.
lncRNA FAM230B is highly expressed in colorectal cancer and suppresses the maturation of miR-1182 to increase cell proliferation
Authors: Li Ni , Zhou Chuane , Yang Fan
Published: October 2022

Long non-coding RNA FAM230B and microRNA (miR-1182) have been characterized as critical players in cancer biology, while their roles in colorectal cancer (CRC) are unclear. We predicted that they could interact with each other and therefore explored the interaction between them in CRC. CRC and paired non-tumor tissue samples were collected from 60 CRC patients, and the expression of FAM230B and miR-1182 (premature and mature) in these samples was analyzed with RT-qPCR. The direct interaction between FAM230B and premature miR-1182 was analyzed with RNA-RNA pull-down assay, and the subcellular location of FAM230B was detected with subcellular fractionation assay. The interaction between FAM230B and miR-1182 was explored with overexpression assay, and their roles in regulating CRC cell proliferation, viability, and colony formation were assessed by BrdU assay, MTT assay, and colony formation assay, respectively. We found that FAM230B and premature miR-1182 were highly upregulated in CRC, while mature miR-1182 was downregulated in CRC. FAM230B was detected in both nucleus and cytoplasm, and it directly interacted with miR-1182. FAM230B overexpression increased the expression levels of premature miR-1182 but decreased the expression levels of mature miR-1182 in CRC cells. FAM230B promoted CRC cell proliferation, increased cell viability, accelerated colony formation, and suppressed the role of miR-1182 in inhibiting CRC cell proliferation. In conclusion, FAM230B is upregulated in CRC and it suppresses the maturation of miR-1182 to promote tumor growth.
Brucellatransmission from domestic and wild animals to dromedary camel: Diagnostic methods and zoonotic threats – A review
Authors: Adel Mammeri
Published: October 2022

The present review discusses the transmission risk factors of camel (Camelus dromedarius) brucellosis in the limits of domestic and wild interfaces and zoonotic threats. The median position of the dromedary’s life between wild and the domestic areas seems to increase the risks of brucellosis transmission, compared to other receptive domestic ruminants. In arid environments, canids, lagomorphs, rodents, and wild boars are potential reservoirs ofBrucellaspp. Dromedary camels raised according to a periurban breeding system are often in direct or indirect contact with wild animals, domestic animals, and humans. Constraints of brucellosis detection and control in wild animals, especially in developing countries, hamper preventing disease in camelids and related occupational categories. A total eradication of animal and human brucellosis, in developing countries, is faced by the difficulty of applying quarantine periods for suspected animals, the lack of reliable diagnostic tools, and the impossibility of controlling animals at the common grazing lands, livestock markets, and transboundary areas. In developing countries, the informal she-camel milk collection, the periurban camel breeding, and the shortage in the technological processing and the pasteurization of she-camel milk play a key role in brucellosis zoonotic transmission.Veterinarians should have more initiative in brucellosis control in both domestic and wildlife animals.
The Eastern Mediterranean Energy Bonanza: A Piece in the Regional and Global Geopolitical Puzzle, and the Role of the European Union
Authors: Badarin Emile , Schumacher Tobias
Published: October 2022

This article examines current energy-related disputes in the Eastern Mediterranean. It does so by situating them in the context of the Middle East’s broader geopolitical landscape and by showing how global powers’ interests and involvement have become contingent on the international and regional political environments. The latter augmented the intensity of the contestation and helped move identifiable and tangible factors, such as Exclusive Economic Zones, into the imaginative realms of geopolitics. They also provided the concerned actors with opportunities to balance out their adversaries and, by implication, diminished their willingness to compromise. Although the global powers’ interest in Eastern Mediterranean energy resources is limited, the European Union does have interests in these reserves and related aspects. The fact that the monetisation of these resources is highly dependent on the EU market provides the EU with an immense amount of “buyer power” to stabilise the region and potentially balance the fears of both Greece and Turkey.
Big (Crisis) Data in Refugee and Migration Studies – Case Study of Ukrainian Refugees
Authors: Jurić Tado
Published: October 2022

This paper presents a review of Big Data sources that could be helpful in determining, estimating, and forecasting the forced emigration flows of refugees from Ukraine. The text shows how a Big Data approach can help assess refugees’ intentions. Using insights from social-media platforms such as Facebook, Instagram, and YouTube is useful, because data here are available faster than any official data in the refugee crisis triggered by the Russian attack on Ukraine on 24 February 2022.
Emx1-Cre Is Expressed in Peripheral Autonomic Ganglia That Regulate Central Cardiorespiratory Functions
Authors: Ning Yao , Noebels Jeffrey L. , Aiba Isamu
Published: October 2022

The Emx1-IRES-Cre transgenic mouse is commonly used to direct genetic recombination in forebrain excitatory neurons. However, the original study reported that Emx1-Cre is also expressed embryonically in peripheral autonomic ganglia, which could potentially affect the interpretation of targeted circuitry contributing to systemic phenotypes. Here, we report that Emx1-Cre is expressed in the afferent vagus nerve system involved in autonomic cardiorespiratory regulatory pathways. Our imaging studies revealed expression of Emx1-Cre driven tdtomato fluorescence in the afferent vagus nerve innervating the dorsal medulla of brainstem, cell bodies in the nodose ganglion, and their potential target structures at the carotid bifurcation such as the carotid sinus and the superior cervical ganglion (SCG). Photostimulation of the afferent terminals in the nucleus tractus solitarius (NTS)in vitrousing Emx1-Cre driven ChR2 reliably evoked EPSCs in the postsynaptic neurons with electrophysiological characteristics consistent with the vagus afferent nerves. In addition, optogenetic stimulation targeting the Emx1-Cre expressing structures identified in this study, such as vagus nerve, carotid bifurcation, and the dorsal medulla surface transiently depressed cardiorespiratory rate in urethane anesthetized micein vivo. Together, our study demonstrates that Emx1-IRES-Cre is expressed in the key peripheral autonomic nerve system and can modulate cardiorespiratory function independently of forebrain expression. These results raise caution when interpreting systemic phenotypes of Emx1-IRES-Cre conditional recombinant mice, and also suggest the utility of this line to investigate modulators of the afferent vagal system.
Magnetic properties of wood treated with nano-magnetite and furfuryl alcohol impregnation
Authors: Wahyuningtyas Irma , Rahayu Istie , Maddu Akhiruddin , Prihatini Esti
Published: October 2022

The impregnation of jabon wood (Anthocephalus cadamba Miq.) with a magnetic compound can increase the quality of the wood. In this study, magnetic woods were made using the ex situ impregnation of jabon woods with nano-magnetite (Fe3O4). The objective of this study was to analyze the characteristics of jabon magnetic wood. Two other impregnation solutions were also used in this study: (1) water (untreated) and (2) furfuryl alcohol plus nano-magnetite. The physical properties of magnetic jabon wood were improved compared with untreated wood, as shown by the results of the characterization tests. Scanning electron microscopy with energy-dispersive X-ray spectroscopy showed nano-magnetite in the micropores of magnetic jabon wood. The results of the Fourier-transform infrared spectroscopy showed chemical bonding between the wood polymer and the furan ring and Fe-O functional groups. The X-ray diffraction results showed a decrease in the degree of crystallinity as the concentration of nano-magnetite increased. The magnetic properties were tested via vibrating-sample magnetometry and the FA-Fe3O4-treated wood showed the highest magnetization.
Van der Waals equation of state for asymmetric nuclear matter
Authors:   Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Sanzhur A.I.
Published: October 2022

The application of the van der Waals equation of state to the asymmetric nuclear matter is considered in a critical state region. The corrections to the van der Waals pressure and free energy due to the Fermi statistics are obtained starting from the Thomas - Fermi entropy expression which ensures the fulfilment of the Nernst theorem. The derived corrections account for the effective nucleon mass and neutron-proton isotopic asymmetry. The parameters of the van der Waals equation of state are deduced by taking the experimental value of critical temperature for symmetric nuclear matter and testing the model of van der Waals with statistics corrections included against the theory of Skyrme energy density functional. A critical line in pressure-temperature-composition space is considered. The incompressibility coefficient is determined along the critical line as a function of nuclear matter composition. A jump in the value of specific heat upon crossing a critical line is discussed.
The role of urban green areas in noise pollution attenuation
Authors: Nunho dos Reis Allan Rodrigo , Biondi Daniela , Dias de Oliveira Jefferson
Published: October 2022

This study aimed to evaluate the relationship between the biophysical characteristics of green areas with the reduction of noise propagation.The study was conducted in two green areas located in the city of Curitiba, Paraná, Brazil. Noise pollution levels along with the vegetation and the physical characterization were collected in each plot site of 600m2. The attenuated pollution values were defined and compared with the physical characteristics. The attenuated noise values varied from 1.7 to 14.8 dBeq. The vegetation proved to be efficient in attenuating noise pollution, showing that the site with the least amount of vegetation obtained the lowest noise attenuation values. The density and number of trees showed very strong correlations with the blocked decibel values. A combination of factors such as the shape and size of the fragments with the terrain conditions (terrain slope, and coverage) influenced the noise propagation.
Spatio-temporal prediction of water production in basins without records
Authors: Marquez Adriana Mercedes , Guevara Pérez Edilberto , Pérez Pacheco Sergio Alejandro , Buroz Castillo Eduardo
Published: October 2022

This study carried out the spatio-temporal prediction of water production in two micro-basins without records, located in Venezuela. Geomorphological characteristics of micro-basins were obtained using digital elevation models acquired from ALOS PALSAR satellite. Two models were included for spatio-temporal prediction of hydrometeorological variables. The first model involved deterministic and stochastic components, calibrated using two-time series (TS). TS-1 consisted of records from 227 precipitation stations and 62 evaporation stations managed by the Environment Ministry during 1980-1999. TS-2 included records from 28 precipitation stations and 18 evapotranspiration stations collected by the National Institute of Meteorology and Hydrology during 2015-2018. The second model estimated effective precipitation from TS-2 precipitation maps, runoff coefficient from land use and land cover (LULC) prediction. The LULC was estimated on 59 Landsat 8OLI images for 2015-2018. The validation was carried out with observations of the Hydrological Central Company, resulting in determination coefficients upper to 0.95.
Applying hydrological modeling to unravel the effects of land use change on the runoff of a paramo ecosystem
Authors: Cabrera-Balarezo Juan José , Sucozhañay-Calle Adrián Esteban , Crespo-Sánchez Patricio Javier , Timbe-Castro Luis Manuel
Published: October 2022

To gather insight into the impact of afforestation on the hydrology of a mountain river basin a comparative study was conducted with the objective to derive answers to the following questions: 1) How to calibrate the parameters of hydrological models subject to land use change? 2) What is the impact on peaks, total flow, and baseflow when land use gradually changes from tussock-grass to pine plantation? and 3) Is the impact different when land use changes gradually from upstream to downstream (U-D) or from downstream to upstream (D-U)? The results show that total flow, baseflow and peaks are respectively reduced by 21%, 66% and 21%. This study presents a calibration approach to quantify the effects of land use change before it is done.
Arsénico en aguas subterráneas de la cuenca del río Callacame y su impacto en suelos agrícolas en Desaguadero, Puno – Perú
Authors: Calcina-Benique Miguel Elías , Calcina-Rondán Liliam Elizabeth , Huaraya-Chambi Froilán Rodolfo , Salas-Camargo Antonio Renán , Tejada-Meza Kevin
Published: October 2022

El arsénico es un elemento natural presente en el medio ambiente tanto en formas orgánicas como inorgánicas, siendo el arsénico inorgánico el más tóxico. El objetivo de la presente investigación fue cuantificar el arsénico presente en aguas subterráneas y muestras de suelo e identificar el impacto en los suelos agrícolas de la cuenca del río Callacame. En el caso de las aguas subterráneas se tomaron en cuenta 32 puntos de muestreo y en el caso de suelo 4 puntos de muestreo. Se colectaron y prepararon las muestras para su posterior análisis con la metodología EPA 6020 utilizando un ICP-MS, adicionalmente se tomaron parámetros fisicoquímicos de pH, CE, STD y ORP, Fe, Mg, Na y K. Los resultados mostraron concentraciones de arsénico en aguas subterráneas del orden de 3 a 446 ug/L, en suelos de 10 a 42,7 mg/Kg. En el caso de agua subterránea existieron 4 puntos que sobrepasaron los estándares de calidad ambiental para el país de origen de las muestras (Perú), en el caso de suelo no hubo concentraciones que sobrepasen los estándares de calidad ambiental por lo que se determinó que actualmente no representan un impacto ni riesgo ambiental o hacia la salud. Sin embargo, se concluyó que en un futuro si no se cuenta con la vigilancia adecuada pueden darse pie a procesos de bioacumulación y biomagnificación producto del riego de suelos con aguas subterráneas contaminadas con arsénico.
Numerical modeling to evaluate tensile mechanical and shear failure of cement in the casing-cement interface
Authors: Mayorga-Ribero Karina Andrea , Gambús-Ordaz Maika Karen , Palencia-Muñoz Miguel Fernando , Suárez-Arias Diego Fernando
Published: October 2022

This paper presents a numerical model of an integrated 3D casing-cement-formation system, to evaluate the mechanical tensile and shear failure of the cement at the casing-cement interface as the pressure and temperature conditions of the formation and borehole vary during production. The model which includes the formation pressure, unlike others proposed, was developed by stages under finite element discretization and compared to analytical models. Results show that increasing the formation temperature increases the probability of tensile and shear failure in the cement, while increasing the wellbore temperature decreases these probabilities. On the other hand, the decrease in the well pressure reduces the probability of shear failure and increases the tensile failure. In the case of formation pressure, the opposite occurs.
Calidad de vida y funcionalidad en sobrevivientes de cuidados intensivos: Una revisión exploratoria
Authors:   Fundación Universitaria del Área Andina, Mejía Vanegas Dulfary , Arias Díaz Julia Andrea , Leyton Toro Lleraldyn , Ayala Grajales Katherine Yuliet , Becerra Londoño Angie Manuela , Vallejo Ospina Jorge Iván , Rincón Hurtado Ángela María
Published: October 2022

Introducción: La calidad de vida en pacientes críticos que sobreviven al tratamiento en unidades de cuidados intensivos es inferior al de la población general. La condición de salud basal y la severidad de la condición clínica al ingreso a terapia intensiva son factores de riesgo para la calidad de vida y la funcionalidad. Objetivo: Analizar el nivel de conocimiento en la calidad de vida y la funcionalidad de los sobrevivientes de cuidados intensivos. Materiales y métodos: Se realizó una revisión exploratoria en las bases de datos: Scielo, PubMed, Science Direct, ProQuest, Redalyc, Dialnet, OVID, Scopus, publicados entre enero del año 2010 y mayo del año 2020. El estudio se desarrolló según la estructura de la Metodología PRISMA. Se revisaron y analizaron los textos completos que cumplían los criterios de inclusión para la selección final de los artículos. Resultados: De 1814 artículo seleccionados, se eligieron 65 artículos que describen la calidad de vida y la funcionalidad en pacientes después de cuidados intensivos, y finalmente, 16 artículos son incluidos, donde se analizaron las características de los artículos, las características de la población estudiada, y las variables de análisis sobre la evaluación de la calidad de vida y la funcionalidad en los sobrevivientes después cuidados intensivos. Conclusión: Los estudios sobre calidad de vida y funcionalidad en sobrevivientes de cuidados intensivos se realizaron en mayor proporción en Europa en los años 2010 a 2016. Con estudios observacionales prospectivos que correlacionan los factores que determinan la salud mental y física después del egreso de cuidados intensivos. Se aplicaron múltiples escalas siendo las más utilizadas SF-36 y el EQ-5D para evaluar la calidad de vida y del índice de Barthel para determinar el estado de funcionalidad en los egresados de cuidados intensivos. El SF-36 y el índice de Barthel reportaron una afectación en la calidad de vida y en la funcionalidad en la población sobreviviente de cuidados intensivos.
Effects of Molecular Weight of Dextran on Dynamic Mechanical Properties in Functional Polymer Blend Systems
Authors: KAVLAK Serap
Published: October 2022

Blending of natural/synthetic polymers is one of the most practical way to obtain a new material with desired properties such as thermal, mechanical and dynamic mechanical properties. Dynamic mechanical analysis (DMA) is a strong method to investigate the mechanical/viscoelastic properties, thermal transitions and compatibility in these polymer blend systems. In this study, biocompatible T10 and T40 dextran (DEX) and polymethacrylamide (PMAM) blend systems were prepared by solvent casting method. Variations of dynamic mechanical properties including storage modulus (SM), loss modulus (LM) and tan δ of the DEX/PMAM blends were investigated for all samples at a specific fixed frequency of dynamic mechanical loading in a certain temperature range. Thermal transitions and -relaxations were observed from results of DMA measurements. In general, a single glass transition temperature was observed in binary blend systems. It was found that temperature dependence of dynamic mechanical properties and curves exhibit typical behaviors and strongly depended on the molecular weight, intra- and intermolecular interactions due to the hydrogen bonding in these blend systems.
siRNA targeting ABCB1 potentiates the efficacy of chemotherapy in human triple-negative breast cancer cells
Authors: KARA Göknur
Published: October 2022

Diminishing the efficacy of chemotherapy because of multidrug resistance (MDR) is a major clinical problem for triple-negative breast cancer (TNBC). MDR often occurs by overexpression of ATP-binding cassette B1 (ABCB1) protein that effuses various anticancer drugs from cancer cells. One of the newly developed techniques to addressing MDR is to knockdown ABCB1 by RNA interference (RNAi). RNAi is a gene-silencing process in that small interfering RNA (siRNA) blocks the expression of desired genes with high efficiency/specificity. The aim of this work is to examine the impact of ABCB1 inhibition via specific siRNAs on the efficacy of paclitaxel or etoposide in TNBC cells. The toxicity of increasing paclitaxel and etoposide concentrations on MDA-MB-231 cells was assessed using the MTT test. Cells were then co-treated with paclitaxel or etoposide in combination with ABCB1-siRNA, followed by cytotoxicity, colony formation, and migration assays. The administration of ABCB1-siRNA with paclitaxel or etoposide exhibited a synergistic effect and siRNA-drug treatments markedly reduced viability, clonogenicity, and migration of TNBC cells compared to siRNA or drug alone. Overall, these results indicate that TNBC cells become vulnerable even to sub-toxic doses of paclitaxel and etoposide after ABCB1-siRNA transfection, representing a promising aproach to enhance the influence of chemotherapy in TNBC.
The Constellation of Oleg Inshakov in the University Universe
Authors:   Volgograd State University, Kalinina Alla , Inshakova Elena ,   Volgograd State University
Published: October 2022

The article is dedicated to the Honored Scientist of the Russian Federation Oleg V. Inshakov, on the 70th anniversary of his birth. Oleg Inshakov is a widely renowned outstanding scientist, a talented organizer in the sphere of science and education, a well-known state official and public figure. The article provides biographical facts of the period of study and work of Oleg Inshakov at Rostov State University, and reveals his role in the development of Volgograd State University as a classical university, a strategic regional center of science, education, culture and advanced technologies. Through the prism of Oleg Inshakov’s scientific achievements, the paper shows the evolution of the scientific school he created and the interdisciplinary projects implemented by its representatives. Learners and colleagues of Oleg Inshakov share their memories of the teacher, supervisor and mentor.
Viticulture and Winemaking as a Driver for Economic Growth of Sevastopol
Authors:   Sevastopol State University, Piskun Elena , Khokhlov Vladimir ,   Sevastopol State University
Published: October 2022

At the present stage of economic development, the most urgent problem is to stimulate economic growth and ensure sustainable investment development in the region. Each regional subject has its own natural, climatic, historical and economic features. In this regard, there is a need to identify drivers of economic growth. The aim of the work is economic and mathematical modeling of the probability of yield of vineyards in order to make adaptive decisions of existing winegrowers and investment decisions on investing in this industry based on the study of viticulture and winemaking as a propulsive industry of the federal city of Sevastopol. The authors analyzed the current state of the industry, the dynamics and priorities of its development. The results of this study can be recommended for use by both functioning and potential winegrowers and winemakers in making management decisions and developing business plans. Public authorities, primarily at the local level, can use the proposed economic and mathematical modeling in the development of projects, programs for the development of viticulture and winemaking, the region as a whole.
End-to-End Neurotechnologies in the Development of Modern Territorial Brand Identification Systems
Authors:   V.I. Vernadsky Crimean Federal University, Yarosh Olga , Zhavoronkova Zinaida ,   V.I. Vernadsky Crimean Federal University
Published: October 2022

The article presents the results of experimental studies of two visual communication systems. The analysis of biometric data obtained as a result of neuromarketing experiments on the study of visual identifiers of territories – coats of arms and logos was carried out. The interrelation of the visual prominence of symbols with its color solutions is investigated, the assessment of perceptual fluency in processing and the impact on memorability in the consumer is carried out. The visual prominence of identity in a competitive environment is revealed. It is shown that the use of heraldry as a modern brand identification system is somewhat difficult. Therefore, its development is associated with the development and promotion of easy-to-interpret, visually noticeable symbols that can be fluently perceived in the chain of mnemic processes associated with the assimilation of visual information.
Professional Education in the Conditions of Industry 4.0: Global Challenges of Modernity, Contradictions, Perspectives of Improvement
Authors:   Volgograd State University, Gushchina Elena , Melnik Tatiana ,   Volgograd State University, Maletina Oksana ,   Volgograd State University
Published: October 2022

The authors analyzed the dialectical contradictions in the development of the institution of education in Russia, which impede the sustainable growth of the national economy, the development of society and the strengthening of Russia’s competitiveness in the international arena. In their study the authors rely on the conceptual and categorical apparatus, global patterns of social development and other basic provisions of the theory of Risk Society by U. Beck and his followers. The writing of the article was greatly influenced by the provisions of the theory of the Creative class by R. Florida and others. The methodological basis of the study was the developments, concepts and hypotheses presented in the publications of domestic scientists, reflecting the practice of functioning of Russian educational institutions. The development and justification of practical recommendations were carried out on the basis of the implementation of general scientific approaches; within the framework of a systematic approach, when writing the article, methods of comparative and logical analysis were used. Based on the results of the analysis it was proposed to apply a marketing approach for the timely identification of the needs and requirements of all participants regarding the formation of demanded specialists on the labor market; perspectives of improving the educational process for the development of cross-professional students’ skills, subsequently contributing to the formation of transprofessionals, have been identified.