bluuebunny/crossref_metadata_2025 huggingface dataset:
Reliability, Validity, and Sensitivity to Change of the Lower Extremity Functional Scale in Individuals Affected by Stroke
Authors: Verheijde Joseph L. , White Fred , Tompkins James , Dahl Peder , Hentz Joseph G. , Lebec Michael T. , Cornwall Mark
Published: July 2013

Objective

To investigate reliability, validity, and sensitivity to change of the Lower Extremity Functional Scale (LEFS) in individuals affected by stroke. The secondary objective was to test the validity and sensitivity of a single‐item linear analog scale (LAS) of function.

Design

Prospective cohort reliability and validation study.

Setting

A single rehabilitation department in an academic medical center.

Patients

Forty‐three individuals receiving neurorehabilitation for lower extremity dysfunction after stroke were studied. Their ages ranged from 32 to 95 years, with a mean of 70 years; 77% were men.

Methods

Test‐retest reliability was assessed by calculating the classical intraclass correlation coefficient, and the Bland‐Altman limits of agreement. Validity was assessed by calculating the Pearson correlation coefficient between the instruments. Sensitivity to change was assessed by comparing baseline scores with end of treatment scores. Measurements were taken at baseline, after 1‐3 days, and at 4 and 8 weeks.

Main Outcome Measurements

The LEFS, Short‐Form‐36 Physical Function Scale, Berg Balance Scale, Six‐Minute Walk Test, Five‐Meter Walk Test, Timed Up‐and‐Go test, and the LAS of function were used.

Results

The test‐retest reliability of the LEFS was found to be excellent (ICC = 0.96). Correlated with the 6 other measures of function studied, the validity of the LEFS was found to be moderate to high (r = 0.40‐0.71). Regarding the sensitivity to change, the mean LEFS scores from baseline to study end increased 1.2 SD and for LAS 1.1 SD.

Conclusion

LEFS exhibits good reliability, validity, and sensitivity to change in patients with lower extremity impairments secondary to stroke. Therefore, the LEFS can be a clinically efficient outcome measure in the rehabilitation of patients with subacute stroke. The LAS is shown to be a time‐saving and reasonable option to track changes in a patient's functional status.
Acute Injury Risk and Severity in Indoor Climbing—A Prospective Analysis of 515,337 Indoor Climbing Wall Visits in 5 Years
Authors: Schöffl Volker R. , Hoffmann Georg , Küpper Thomas
Published: July 2013

Objective

Rock climbing’s popularity continues to rise, with people of all ages regularly participating in the sport. Climbing literature suggests climbers get injured mostly in their upper extremities. Most studies on climbing injury analysis are conducted retrospectively, with all the inherent problems of a retrospective setup (no exact time collection, biased injury perception, etc). Prospective data are still missing.

Methods

We prospectively evaluated all attendees of a major German indoor climbing gym in Stuttgart, Germany, with bouldering and lead climbing facilities. Attendee’s age, sex, and time spent climbing were electronically recorded on each visit. All acute injuries were graded using the Medical Commission of the Union Internationale des Associations d’Alpinisme Score. Injury cause, belayers’ and climbers’ experience, and outcome were additionally analyzed.

Results

During a 5-year period (2007–2011), 515,337 visits to the climbing wall were registered, of which 63.6% were by male visitors, 36.4% female, within an age of 8–80 years (median, 34 years). The average time of climbing was 2 hours 47 minutes. Thirty climbing injuries were recorded, 22 were in male and 8 in female climbers with a total mean age of 27.5 ± 10.6 years. Acute injuries happened in 6 cases while bouldering, in 16 cases while lead climbing, in 7 cases while top roping, and in 1 case as a third person (not climbing or belaying) while watching another climber. Bouldering injuries were mostly the result of falls onto the mat, whereas in lead and top rope climbing various scenarios happened. Fifteen (50%) injuries were Medical Commission of the Union Internationale des Associations d’Alpinisme grade 2, 13 (43%) were grade 3, and 2 (7%) were grade 4, with no fatalities. The overall injury rate was 0.02 injuries per 1000 hours of climbing activities.

Conclusions

This was the first study to accurately record time spent indoor climbing digitally and evaluate the acute injuries prospectively in a large cohort. There were few injuries sustained, suggesting indoor climbing has a low risk of acute injury per 1000 hours of participation. The injuries were of minor to moderate injury severity, and no fatalities occurred. Several injuries could have been avoided, and further injury-prevention concepts should be developed.
Quaternary eolian dunes in the Savannah River Valley, Jasper County, South Carolina, USA
Authors: Swezey Christopher S. , Schultz Arthur P. , González Wilma Alemán , Bernhardt Christopher E. , Doar William R. , Garrity Christopher P. , Mahan Shannon A. , McGeehin John P.
Published: July 2013

Sand hills in the Savannah River valley in Jasper County (South Carolina, USA) are interpreted as the remnants of parabolic eolian dunes composed of sand derived from the Savannah River and stabilized by vegetation under prevailing climate conditions. Optically stimulated luminescence ages reveal that most of the dunes were active ca. 40 to 19 ka ago, coincident with the last glacial maximum (LGM) through early deglaciation. Modern surface winds are not sufficient for sustained eolian sand transport. When the dunes were active, winds blew at velocities of at least 4 m/s from west to east, and some vegetation was present. The ratio of annual precipitation to potential evapotranspiration (P:PE) was less than the modern ratio of 1.23 and may have been < 0.30, caused by stronger winds (which would have resulted in greater evaporation) and/or reduced precipitation. The Savannah River dunes are part of a larger assemblage of eolian dunes that were active in the eastern United States during and immediately after the LGM, suggesting that eolian sediment behavior in this region has been controlled by regional forcing mechanisms during the Quaternary.
Éthique et risques dans la réglementation des biotechnologies : La prise en compte des questions normatives dans les processus d’homologation contemporains
Authors: Lord Francis , Létourneau Lyne
Published: July 2013

Les régimes qui réglementent l’introduction des biotechnologies sur un territoire donné reposent sur le processus d’homologation—un processus décisionnel qui vise à identifier, évaluer, et minimiser les risques associés à l’introduction d’un produit ou d’une substance. Les processus d’homologation comprennent un examen des risques qui est présenté comme étant neutre, empirique et strictement scientifique. Malgré cela, plusieurs jugements de valeur surviendront au moment de cet examen en raison des « questions normatives » qui y surgissent immanquablement. En revanche, une analyse des dispositions provenant de divers régimes canadiens, américains, et européens démontre que ceux-ci abordent et même résolvent certaines questions normatives. Ce faisant, ils mettent en valeur le rôle actuel et potentiel des règles législatives, réglementaires, et administratives pour arbitrer le contenu scientifique et éthique des processus d’homologation.
Gender Equality from Beneath: Electoral Gender Quotas in Poland
Authors: Śledzińska-Simon Anna , Bodnar Adam
Published: July 2013

This article explores the introduction of electoral gender quotas and the unprecedented social mobilization in pursuit of gender equality in Poland. The quota law was adopted as a citizens’ initiative organized by the Congress of Women, a new women’s movement. The article analyzes the factors that account for the success of this initiative, which permanently changed the public debate on gender rights in Poland. In contrast to other countries with legislative gender quotas, the Polish law was the result of bottom-up processes, and it has a strong democratic legitimacy. The law has not significantly influenced the representation of women in the Parliament, yet it significantly mainstreamed the gender perspective in the public debate. Nonetheless, the way in which the quota law has been applied by political parties shows that Polish women in politics are a “minority” devoid of power, and that the prospects for a parity democracy are still remote.
Remembering and Forgetting the Scottish Highlands: Sir James Mackintosh and the Forging of a British Imperial Identity
Authors: Gust Onni
Published: July 2013

This article explores the formation of British imperial identity through a focus on the career of Sir James Mackintosh (1765–1832), a well-known Whig intellectual and imperial careerist who originally hailed from the Highlands of Scotland. Using Mackintosh's unpublished letters and autobiography, the article shows how he imagined and narrated his relationship to the Scottish Highlands from the vantage points of Bombay and London. In contrast to recent historiography that has focused on the translation of Scottish society, culture, and identity in British imperial spaces, this article argues that disidentification from the Highlands of Scotland and the erasure of different peoples, cultures, and textures of life was integral to Mackintosh's configuration of a British imperial identity.
Reducing That Barbarous Country: Center, Periphery, and Highland Policy in Restoration Britain
Authors: Kennedy Allan Douglas
Published: July 2013

Despite a recent expansion of interest in the history of Restoration Scotland, historiographical engagement with the place of the Highlands in the Restoration state continues to be relatively limited. Building upon recent research into the political culture of the later seventeenth century, this article offers a new conceptualization of the relationship between the center and the Highland periphery. It argues that the region was heavily integrated into wider political circumstances, while recognizing that contemporary statesmen remained concerned about its perceived wildness. From this basis, the article moves on to consider the nature of Highland policy, suggesting that tactical shifts spoke of deeper strategic uncertainty as to whether the Highlands were best controlled through the direct imposition of government power or by close cooperation with local elites.
The “New World of Children” Reconsidered: Child Abduction in Late Eighteenth- and Early Nineteenth-Century England
Authors: Foyster Elizabeth
Published: July 2013

This article argues that in late eighteenth- and early nineteenth-century England, changes in the perceived value of children, both materially and emotionally, put them in a new position of possible danger. The valorization of childhood brought new risks to children. Children were thought to be vulnerable to child abduction, or “child stealing,” as contemporaries termed it. Between 1790 and 1849, 108 cases of child abduction were tried at the Old Bailey and then recorded in itsProceedingsor heard before magistrates in London's police courts and at county sessions courts and subsequently reported in newspapers. These cases, along with fictional accounts of child abduction, give insights into what were considered the most common motives for this crime. While some child abductors were motivated by poverty and saw children's clothes as economic assets that could be sold, others were driven by a desire to assume a mother role and represented stolen children as their own. Popular interest in abduction stories was sustained while contemporaries shared common fears about the loss of children and the limitations of adults to protect children from harm.
Immoral Traffic: Mobility, Health, Labor, and the “Lorry Girl” in Mid-Twentieth-Century Britain
Authors: Laite Julia
Published: July 2013

The story of the lorry girl and the lorry driver, the roads they traveled on, and the responses toward them allows for some telling insights into a strange kind of “immoral traffic” in 1930s and 1950s Britain. Whether seeking employment or adventure, leaving the “distressed areas” or absconding from an approved school, the lorry girl was linked to anxieties about women's mobility, unemployment, venereal disease, and delinquency. At the same time, the figure of the lorry driver, both romanticized and marginalized, showed that deviant and commercialized sexuality could be linked to the economic and social inequality of both men and women. Concerns about lorry jumping and hitchhiking in this period also reveal a different kind of narrative in the development of British roadways, which not only were tied to both the health and efficiency of the nation but also were spaces of sexual danger and sites of social delinquency.
Morale and the Postwar Politics of Consensus
Authors: Ussishkin Daniel
Published: July 2013

The aftermath of the Second World War saw massive efforts to promote morale management across British industry. While these new discourses and industrial practices have often been explained in terms of the development of expert knowledge, this article places them at the center of the politics of social reconstruction. While the proper management of morale was linked to greater productivity, this article argues that it was often their assumed benefits regarding social cohesion and harmony that mattered most. It shows the ways in which government officials, management experts, and social scientists mobilized the perceived links that the war had forged among morale, collective sacrifice, and democratic citizenship and thus turned the workplace into a privileged site for the manufacture of consensus.
From Theory to Practice: Two Ecosystemic Approaches and Their Applications to Understanding School Bullying
Authors: Mc Guckin Conor , Minton Stephen James
Published: July 2013

School professionals, particularly school counsellors and school psychologists, require detailed knowledge of many important factors that contribute to the personal, academic, and vocational development of the students in their charge (e.g., psychosocial development, curricula developments, local community developments and initiatives, national and international policy developments). The amount of detail and knowledge required by school counsellors/psychologists is bewildering, even before consideration of the individual differences in those who require their help. A framework can provide school professionals with a parsimonious approach to organising, synthesising and understanding all the information that needs to be considered in relation to a child within a particular environment. The current article reviews and comments upon the usefulness of two such theoretical frameworks — Bronfenbrenner's ecological model (1979, 1989) and Spiel, Reimann, Wagner, and Schober's (2008) Bildung-Psychology approach — to an exploration and understanding of a common issue; namely, bully/victim problems among school pupils. It is argued that such ecological/systemic approaches could usefully inform the design and evaluation of future efforts to address school bullying and violence. By extension, we propose that the simplicity of such models is of great value to the school professional who seeks a framework that can guide them in their work.
Palaeoenvironmental significance of lacustrine stromatolite forms from the Middle Old Red Sandstone of the Orcadian Basin
Authors: ANDREWS S. D. , TREWIN N. H.
Published: July 2013

The form of microbialite accumulations is largely the product of environmental processes and microbial activity. Recent work has largely concentrated on the identification and classification of microbialites with little attention being paid to their environmental significance. This study describes the environmental distribution of the varied stromatolite forms recorded from the Middle Old Red Sandstone sequences of the Orcadian Basin. Comparisons are made with Triassic examples from East Greenland and modern microbialite accumulations. The Middle Old Red Sandstone of Northern Scotland was deposited in a predominantly lacustrine setting. Stromatolites are recorded from both steep basin margin coincident settings and lower gradient settings where the lake margin was distant from the basin margin. In the latter case stromatolite development is largely restricted to transgressive lacustrine sequences, during the deposition of which reduced rates of sedimentation resulted from the migration of sediment input points towards the basin margin. Stromatolite sheets, domal mounds, aligned mounds (and associated runnels), sand-cored stromatolite mounds and reefal stromatolite accumulations have been identified representing the transition from more sheltered to more exposed environments. In basin margin coincident settings stromatolite accumulation is restricted to areas of low sedimentation where microbialites coat boulders and pebbles. A model for the palaeoenvironmental distribution of the stromatolite forms described is proposed and is shown to be applicable to similar examples from the Triassic of East Greenland. It is suggested that this model may be more widely applicable to stromatolitic accumulations in similar lacustrine settings through large portions of the Phanerozoic.
Assessment of Hirnantian synglacial eustacy and palaeogeography in a tectonically active setting: the Welsh Basin (UK)
Authors: JAMES DAVID M. D.
Published: July 2013

The Hirnantian stratigraphy of Wales is critically assessed against the global evidence for two major Hirnantian synglacial eustatic lowstands. The evidence for two separate lowstands of relative sea level is locally suggestive in shelf sequences but generally only permissive in the basin. Nowhere can the possible candidate lowstands be separated biostratigraphically and thus basinwide correlation that might rule out local tectonic control is impossible to prove. Consistent with palaeolatitude evidence and a situation far removed from the Gondwana margin, there is no facies evidence (e.g. dropstones) for local glacial conditions and the diamictites are of mass-flow origin. Sequence stratigraphic reasoning proves helpful in the correlation of the basinal succession in Central Wales with the shelf sequences along the Tywi Lineament and the Variscan Front, and suggests that the first appearance ofNormalograptus persculptusin Wales does not correspond with the base of thepersculptusBiozone. Extensive new palaeocurrent data and sedimentological restudy is combined with review of earlier knowledge to argue for significant revisions to previous palaeogeographic maps for ‘generalized lowstand conditions’, notably along the Bala Lineament, the Variscan Front and the Central Wales Inliers.
Volcano-stratigraphy of the extension-related silicic volcanism of the Çubukludağ Graben, western Turkey: an example of generation of pyroclastic density currents
Authors: KARACIK ZEKIYE , GENÇ SENGUL C.
Published: July 2013

Western Turkey's extension-related Cumaovası volcanic rocks (Lower Miocene, 17 Ma) are excellent examples of silicic eruptions. The sub-aerial silicic volcanism at Çubukludağ Graben between İzmir and Kuşadası in west–central Anatolia is mainly in the form of rhyolite domes, lava flows and pyroclastic deposits. The initial features of volcanism derived from phreatomagmatic explosive eruptions from silicic magma that came into contact with lake waters during Neogene times. Most of the volcanic succession represents pyroclastic density currents (PDCs), known as the Kuner ignimbrite. The deposits are fine grained and laminated at the base and pass laterally and vertically into deposits displaying well-developed traction structures, soft sediment deformation and/or erosion channels in the NE part of the region. Alternate deposits of massive, diffusely stratified lapilli and ash are the main products of the later explosive stage. Massive lithic breccias forming the top of the sequences are the proximal facies of the PDCs. The lava phase mainly consists of rhyolite extruded as dome and fissure eruptions of lavas, aligned along NE–SW-trending faults as well as from extensional cracks that are nearly perpendicular to the main graben faults. Considering the tectono-stratigraphical aspects and geochemical nature of the study area, we propose that the Cumaovası silicic volcanism was produced by extension-related crustal melting during the Late–Early Miocene period (17 Ma).
Reduction of aggregation of β-lactoglobulin during heating by dihydrolipoic acid
Authors: Wijayanti Heni B , Oh H Eustina , Sharma Ranjan , Deeth Hilton C
Published: July 2013

Prevention of the heat-induced aggregation of β-lactoglobulin (β-Lg) would improve the heat stability of whey proteins. The effects of lipoic acid (LA, or thioctic acid), in both its oxidised and reduced form (dihydrolipoic acid, DHLA), on heat-induced unfolding and aggregation of β-Lg were investigated. LA/DHLA was added to native β-Lg and the mixture was heated at 70, 75, 80 or 85 °C for up to 30 min at pH 6·8. The samples were analysed by Polyacrylamide Gel Electrophoresis (PAGE) and Size-exclusion HPLC (SE-HPLC). LA was not as effective as DHLA in reducing the formation of aggregates of heated β-Lg. Heating β-Lg with DHLA resulted in formation of more β-Lg monomers (due to dissociation of native dimers) and significantly less β-Lg aggregates, compared with heating β-Lg alone. The aggregates formed in the presence of DHLA were both covalently linked, via disulphide bonds, and non-covalently (hydrophobically) linked, but the amount of covalently linked aggregates was much less than when β-Lg was heated alone. The results suggest that DHLA was able to partially trap the reactive β-Lg monomer containing a free sulphydryl (−SH) group, by forming a ‘modified monomer’, and to prevent some sulphydryl−sulphydryl and sulphydryl−disulphide interactions that lead to the formation of covalently linked protein aggregates. The effects of DHLA were similar to those of N-ethylmaleimide (NEM) and dithio(bis)-p-nitrobenzoate (DTNB). However, the advantage of using DHLA over NEM and DTNB to lessen aggregation of β-Lg is that it is a food-grade compound which occurs naturally in milk.
Using BAD for good: how best available data facilitated a precautionary policy change to improve protection of the prey of the tiger Panthera tigris in Malaysia
Authors: Kawanishi Kae , Clements Gopalasamy Reuben , Gumal Melvin , Goldthorpe Gareth , Yasak Mohd Nawayai , Sharma Dionysius Shankar Kumar
Published: July 2013

Tiger Panthera tigris populations are under threat from poaching and depletion of their prey populations. The National Tiger Action Plan for Malaysia contains several actions addressing the threat of legal and illegal hunting of tiger prey species. One action in this plan required an investigation of whether urgent policy changes were needed to improve the protection of the prey of tigers, based on existing data. As the lack of reliable baseline data prevented us from determining population trends accurately, we compiled camera-trapping data from 23 studies conducted between 1997 and 2008 on four principal tiger prey species (sambar Rusa unicolor, barking deer Muntiacus muntjac, wild boar Sus scrofa and bearded pig S. barbatus) and two potential prey species (gaur Bos gaurus and Malayan tapir Tapirus indicus) and compared their distributions and relative abundances. From 10,145 wildlife photographs spanning 40,303 trap-nights, sambar, bearded pig and gaur appeared to be most threatened given their restricted distribution and low relative abundance. Among these, the gaur has full legal protection and has received more conservation attention than the other two species. Following our assessment and advocacy a 6-year moratorium on hunting both sambar and barking deer was imposed by the Malaysian government and the highest protection status possible was afforded the bearded pig. This case study illustrates how best available data (BAD), in this case from camera-trapping studies, can be harnessed to effect precautionary policy changes to curb the impacts of hunting on threatened predator and prey populations that could crash well before resources would otherwise be available for rigorous scientific assessments.
The impact of parent socio-economic status on executive functioning and cortical morphology in individuals with schizophrenia and healthy controls
Authors: Yeo R. A. , Martinez D. , Pommy J. , Ehrlich S. , Schulz S. C. , Ho B.-C. , Bustillo J. R. , Calhoun V. D.
Published: July 2013

Background

Relatively lower executive functioning is characteristic of individuals with schizophrenia. As low socio-economic status (SES) early in life (i.e. parent SES) has been linked with lower executive skills in healthy children, we hypothesized that parental SES (pSES) would be more strongly related to executive functioning in individuals with schizophrenia than in controls and have a greater impact on prefrontal cortical morphology.

Method

Healthy controls (n = 125) and individuals with schizophrenia (n = 102) completed tests assessing executive functioning and intelligence. The groups were matched on pSES, which was evaluated with the Hollingshead–Redlich scale. A principal components analysis (PCA) was conducted on 10 variables from six executive tests, yielding three specific components (fluency, planning and response inhibition). Voxel-based morphometry (VBM) was used to evaluate effects of pSES on gray matter (GM) concentration.

Results

Lower pSES was associated with lower scores across the three executive functioning components, and a significant group by pSES interaction was observed such that low pSES, in particular, affected individuals with schizophrenia. These effects remained significant when intellectual ability, education and self-SES (sSES) were added as covariates. VBM revealed that lower pSES was associated with reduced GM volume in several anterior brain regions, especially the superior frontal gyrus, in patients but not in controls.

Conclusions

These findings suggest that individuals with schizophrenia may be particularly vulnerable to the adverse impact of low pSES, in terms of both lower executive skills and reduced anterior GM volumes.
The ethics of doing nothing. Suicide-bereavement and research: ethical and methodological considerations
Authors: Omerov P. , Steineck G. , Dyregrov K. , Runeson B. , Nyberg U.
Published: July 2013

Background.

Valuable trauma-related research may be hindered when the risks of asking participants about traumatic events are not carefully weighed against the benefits of their participation in the research.

Method.

The overall aim of our population-based survey was to improve the professional care of suicide-bereaved parents by identifying aspects of care that would be amenable to change. The study population included 666 suicide-bereaved and 377 matched (2:1) non-bereaved parents. In this article we describe the parents' perceptions of their contacts with us as well as their participation in the survey. We also present our ethical-protocol for epidemiological surveys in the aftermath of a traumatic loss.

Results.

We were able to contact 1410 of the 1423 eligible parents; eight of these parents expressed resentment towards the contact. Several participants and non-participants described their psychological suffering and received help because of the contact. A total of 666 suicide-bereaved and 377 non-bereaved parents returned the questionnaire. Just two out of the 1043 answered that they might, in the long term, be negatively affected by participation in the study; one was bereaved, the other was not. A significant minority of the parents reported being temporarily negatively affected at the end of their participation, most of them referring to feelings of sadness and painful memories. In parallel, positive experiences were widely expressed and most parents found the study valuable.

Conclusions.

Our findings suggest, given that the study design is ethically sound, that suicide-bereaved parents should be included in research since the benefits clearly outweigh the risks.
When less is more: a functional magnetic resonance imaging study of verbal working memory in remitted depressed patients
Authors: Norbury R. , Godlewska B. , Cowen P. J.
Published: July 2013

Background

Patients with depression show abnormalities in the neural circuitry supporting working memory. However, it is unclear if these abnormalities are present in unmedicated remitted depressed patients. To address this question, the current study employed functional magnetic resonance imaging (fMRI), in combination with a simple verbal n-back task, in a cohort of unmedicated remitted depressed patients.

Method

We studied 15 healthy control subjects (HC) and 15 unmedicated remitted depressed patients (rMDD). Participants performed a verbal working memory task of varying cognitive load (n-back) while undergoing fMRI. We used multiple regression analyses to assess overall capacity (1-, 2-, 3-back versus 0-back) as well as quadratic modulation of cognitive demand.

Results

Performance accuracy and response latency did not differ between groups, and overall capacity was similar. However, rMDD showed a positive quadratic load response in the bilateral hippocampus; the converse was true for HC.

Conclusions

Our data suggest that remitted depression was associated with a perturbed pattern of activation in the bilateral hippocampus during a verbal working memory task. We propose that a reduced ability to dampen task-irrelevant activity may reflect a neurobiological risk factor for recurrent depression.
A longitudinal examination of neuropsychological and clinical functioning in boys with attention deficit hyperactivity disorder (ADHD): improvements in executive functioning do not explain clinical improvement
Authors: Coghill D. R. , Hayward D. , Rhodes S. M. , Grimmer C. , Matthews K.
Published: July 2013

Background

Attention deficit hyperactivity disorder (ADHD) often, but not always, persists into adulthood. Investigations of the associations between clinical and biological markers of persistence can shed light on causal pathways. It has been proposed that compensatory improvements in executive neuropsychological functioning are associated with clinical improvements. This is the first study to test this hypothesis prospectively.

Method

The clinical and neuropsychological functioning of 17 boys with ADHD (mean age 10.45 years at time 1; 14.65 years at time 2) and 17 typically developing (TYP) boys (mean age 10.39 years at time 1; 14.47 years at time 2) was tested on two occasions, 4 years apart. This was done using a battery of standardized neuropsychological tests that included tasks with high and low executive demands.

Results

Clinical improvements were observed over time. Neuropsychological performance improvements were also evident, with ADHD boys developing with a similar pattern to TYP boys, but with a developmental lag. Whilst there was an association between reduced symptoms and superior performance at retest for one task with a high executive demand (spatial working memory), this was not seen with two further high executive demand tasks [Stockings of Cambridge and intra-dimensional extra-dimensional (ID/ED) set shifting]. Also, there was no association between change in executive functioning and change in symptoms. Baseline performance on the ID/ED set-shifting task predicted better clinical outcome. Only change in performance on the low executive demand delayed matching-to-sample task predicted better clinical outcome.

Conclusions

These data highlight the importance of longitudinal measurements of cognition, symptoms and treatment response over time in children and adolescents with ADHD.
Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression
Authors: Macoveanu J. , Knorr U. , Skimminge A. , Søndergaard M. G. , Jørgensen A. , Fauerholdt-Jepsen M. , Paulson O. B. , Knudsen G. M. , Siebner H. R. , Kessing L. V.
Published: July 2013

Background

Healthy first-degree relatives of patients with major depression (rMD+) show brain structure and functional response anomalies and have elevated risk for developing depression, a disorder linked to abnormal serotonergic neurotransmission and reward processing.

Method

In a two-step functional magnetic resonance imaging (fMRI) investigation, we first evaluated whether positive and negative monetary outcomes were differentially processed by rMD+ individuals compared to healthy first-degree relatives of control probands (rMD−). Second, in a double-blinded placebo-controlled randomized trial we investigated whether a 4-week intervention with the selective serotonergic reuptake inhibitor (SSRI) escitalopram had a normalizing effect on behavior and brain responses of the rMD+ individuals.

Results

Negative outcomes increased the probability of risk-averse choices in the subsequent trial in rMD+ but not in rMD− individuals. The orbitofrontal cortex (OFC) displayed a stronger neural response when subjects missed a large reward after a low-risk choice in the rMD+ group compared to the rMD− group. The enhanced orbitofrontal response to negative outcomes was reversed following escitalopram intervention compared to placebo. Conversely, for positive outcomes, the left hippocampus showed attenuated response to high wins in the rMD+ compared to the rMD− group. The SSRI intervention reinforced the hippocampal response to large wins. A subsequent structural analysis revealed that the abnormal neural responses were not accounted for by changes in gray matter density in rMD+ individuals.

Conclusions

Our study in first-degree relatives of depressive patients showed abnormal brain responses to aversive and rewarding outcomes in regions known to be dysfunctional in depression. We further confirmed the reversal of these aberrant activations with SSRI intervention.
Strengthening Market Principles in Welfare Institutions: How Hybrid Pension Systems Impact on Social-risk Spreading
Authors: FRERICKS PATRICIA
Published: July 2013

In the past two decades, the question of how pension systems should be designed to offer ‘adequate and sustainable pensions for all’ has been raised. As a result, European pension systems, in which market principles in general have played a marginal or even negligible role in the past, were redesigned, with market-based pensions becoming part of the pension calculation norm, i.e. the institutionalised and nationally defined target level for old-age protection. However, since the hybrid pension systems are institutionalised very differently, pension systems’ ingredients, characteristics and nexus are far from being homogeneous, and the role of market principles in hybrid systems differs. These differences significantly determine the degree of social protection of the various social citizens and the number of future pensioners with adequate pensions. An illustrative comparison of the contrasting Dutch and German institutional setups indicates differences in the manner in which market principles have been strengthened in the pension system, and the related effects these differences have on social-risk spreading.
A psychophysical evaluation of haptic controllers: viscosity perception of soft environments
Authors: Son Hyoung Il , Jung Hoeryong , Lee Doo Yong , Cho Jang Ho , Bülthoff Heinrich H.
Published: July 2013

In this paper, human viscosity perception in haptic teleoperation systems is thoroughly analyzed. An accurate perception of viscoelastic environmental properties such as viscosity is a critical ability in several contexts, such as telesurgery, telerehabilitation, telemedicine, and soft-tissue interaction. We study and compare the ability to perceive viscosity from the standpoint of detection and discrimination using several relevant control methods for the teleoperator. The perception-based method, which was proposed by the authors to enhance the operator's kinesthetic perception, is compared with the conventional transparency-based control method for the teleoperation system. The fidelity-based method, which is a primary method among perception-centered control schemes in teleoperation, is also studied. We also examine the necessity and impact of the remote-site force information for each of the methods. The comparison is based on a series of psychophysical experiments measuring absolute threshold and just noticeable difference for all conditions. The results clearly show that the perception-based method enhances both detection and discrimination abilities compare with other control methods. The results further show that the fidelity-based method confers a better discrimination ability than the transparency-based method, although this is not true with respect to detection ability. In addition, we show that force information improves viscosity detection for all control methods, as predicted from previous theoretical analysis, but improves the discrimination threshold only for the perception-based method.
Vision-based autonomous hovering for a miniature quad-rotor
Authors: Gomez-Balderas J. E. , Salazar S. , Guerrero J. A. , Lozano R.
Published: July 2013

In this paper, a vision-based scheme for the autonomous hovering of a miniature quad-rotor is developed. Cameras are used to estimate the position and the translational velocity of the vehicle. The dynamic model of the miniature quad-rotor is developed using the Newton–Euler approach. A nonlinear controller based on a separated saturation control strategy for a miniature quad-rotor is presented. To validate the theoretical results, an embedded control system for the miniature quad-rotor has been developed. Thus, the analytic results are supported by experimental tests. Experimental results have validated the proposed control strategy.
Experimental tests of a sliding mode controller for trajectory tracking of a car-like mobile robot
Authors: Hamerlain F. , Floquet T. , Perruquetti W.
Published: July 2013

This paper deals with the problem of the practical tracking control of an experimental car-like system called the Robucar. The car-like Robucar is a four-wheeled car in a single steering mode. Based on a kinematic model of the car-like Robucar, a practical tracking controller is designed using the second-order sliding mode control of the super twisting algorithm. Hence, the output tracking of the desired trajectory is achieved, and the tracking errors vanish asymptotically. Experimental tests on the car-like Robucar are presented for simple and real-time nonholonomic trajectories, and comparative results with the conventional sliding controller demonstrate the applicability and efficiency of the proposed controller.
Show me the pragmatic contribution: a developmental investigation of contrastive inference
Authors: KRONMÜLLER EDMUNDO , MORISSEAU TIFFANY , NOVECK IRA A.
Published: July 2013

An utterance such as ‘Show me the large rabbit’ potentially generates a contrastive inference, i.e., the article the and the adjective large allow listeners to pragmatically infer the existence of other entities having the same noun (e.g. a small rabbit). The primary way to measure children's ability to carry out this pragmatic inference has been through tasks that measure infelicity detection. We argue that such studies are not as revealing as one might assume because they force children to adopt a metalinguistic stance and they consider infelicity detection as tantamount to contrastive inference-making. To address these concerns, we develop a game-like situation in which all utterances remain felicitous. Moreover, we make a distinction between responses that are revealing of a pragmatic interpretation and responses that are revealing of a reliance on the utterance's linguistically encoded meaning (i.e., a lack of contrastive inference). Three experiments with seven-year-olds, ten-year-olds, and adults show that pragmatic interpretations do not emerge among seven-year-olds, that ten-year-olds do not show adult-like performance, and that adults are not at ceiling. We conclude that contrastive inference-making is an effortful process and that the ability to detect such gains-in-information through language increases with age.
English-learning one- to two-year-olds do not show a consonant bias in word learning
Authors: FLOCCIA CAROLINE , NAZZI THIERRY , DELLE LUCHE CLAIRE , POLTROCK SILVANA , GOSLIN JEREMY
Published: July 2013

Following the proposal that consonants are more involved than vowels in coding the lexicon (Nespor, Peña & Mehler, 2003), an early lexical consonant bias was found from age 1;2 in French but an equal sensitivity to consonants and vowels from 1;0 to 2;0 in English. As different tasks were used in French and English, we sought to clarify this ambiguity by using an interactive word-learning study similar to that used in French, with British-English-learning toddlers aged 1;4 and 1;11. Children were taught two CVC labels differing on either a consonant or vowel and tested on their pairing of a third object named with one of the previously taught labels, or part of them. In concert with previous research on British-English toddlers, our results provided no evidence of a general consonant bias. The language-specific mechanisms explaining the differential status for consonants and vowels in lexical development are discussed.
Hooker on Rule-Consequentialism and Virtue
Authors: MILLER DALE E.
Published: July 2013

In Ideal Code, Real World, Brad Hooker proposes an account of the relation between his rule-consequentialism and virtue according to which the virtues (1) have intrinsic value and (2) are identical with the dispositions that are ‘essential parts of accepting the rules’ of the ideal code. While it is not clear whether Hooker actually intends to endorse this account or only intends to moot it for discussion, I argue that for him to adopt it would be a mistake. Not only would this mean that his moral theory was no longer properly a consequentialist view at all, but it would commit him to inconsistent views about how normative theories – in particular theories of morality in the deontic sense and theories of virtue – are justified.
Prevention of falls in old people – a review
Authors: Karlsson Magnus K. , Karlsson Caroline , Cöster Maria , Magnusson Håkan , Rosengen Björn E.
Published: July 2013

Physical training, if including specific different training modalities, reduces the fall risk in healthy community-dwelling older people, as does a home hazards modification programme. Vitamin D supplementation in older individuals with low levels of vitamin D, adjustment of psychotropic medication, and structured modification of multi-pharmacy are all drug-focused programmes that reduce the number of falls. Anti-slip shoe devices during icy conditions for older people who walk outdoors and multifaceted podiatry in patients with specific foot disability reduce the fall risk. First eye cataract surgery and pacemakers in patients with cardio-inhibitory carotid sinus hypersensitivity are surgical interventions that reduce the fall risk. Multi-factorial preventive programmes that include training, both individually designed and generally prescribed, also reduce the fall frequency. With this in mind, we ought to initiate fall preventive programmes in older people, especially in high- risk groups, to reduce the number of falls and fallers in society.
Antidepressant and Group Psychosocial Treatment for Depression: A Rater Blind Exploratory RCT from a Low Income Country
Authors: Husain Nusrat , Chaudhry Nasim , Fatima Batool , Husain Meher , Amin Rizwana , Chaudhry Imran Bashir , Ur Rahman Raza , Tomenson Barbara , Jafri Farhat , Naeem Farooq , Creed Francis
Published: July 2013

Background:Research in the West shows that group psychological intervention together with an antidepressant treatment leads to more effective treatment of a depressive disorder. There are no treatment trials from low income countries comparing the efficacy of antidepressant treatment with a group psychological intervention.Aim:To conduct a feasibility trial to compare the efficacy of an antidepressant to a group psychosocial intervention, for low income women attending primary health care in Karachi, Pakistan.Method:This was a preliminary RCT in an urban primary health care clinic in Karachi, Pakistan. Consecutive eligible women scoring >12 on the CIS-R and >18 on Hamilton Depression Rating Scale (HDRS) (n= 66) were randomly assigned to antidepressants or a psychosocial treatment in group settings. The primary outcome measure was HDRS score; secondary outcome measures were disability and quality of life.Results:More than half of the patients in both groups improved (50% reduction in HDRS scores); at end of therapy at 3 months 19 (59.4%) vs 18 (56.2%), and at 6-month follow-up 21(67.7%) vs 20(62.5%) for antidepressants and psychosocial intervention respectively. Although HDRS, BDQ and EQ5-D scores all improved considerably in both groups from start to end of treatment, and these improvements were largely maintained after a further 3 months, the differences between the two treatments were not statistically significant.Conclusion:Psychosocial intervention was as effective as antidepressants in reducing depression and in improving quality of life and disability at the end of therapy. However, these findings need further exploration through a larger trial.
Reconciling Excavated Textiles with Contemporary Documentary Evidence: a Closer Look at the Finds from a Sixth-Century Tomb at Astana
Authors: ZHAO FENG , WANG LE
Published: July 2013

The excavation of tombs in the Astana graveyard, Turfan, has provided a wealth of evidence for studying everyday life on the Silk Road. Manuscripts and textiles constitute two major groups of the excavated finds. Among the manuscripts are over 60 burial inventories (yiwushu), listing items that would accompany the deceased to the afterlife. Some of the items on the inventories were real and can be identified with objects found in the tombs; some were represented symbolically: for example in miniature form; and others, probably included for formulaic purposes, were imagined. Although there have been several studies on the burial inventories and textiles from Turfan, the two are usually considered separately, with little attention to their correlation, mainly because burial inventories tend to be studied by specialists working on documents, and textiles are usually studied by textile specialists. In 2005 we were fortunate to be able to examine all the textiles from a mid-sixth century tomb at Astana (72TAM170), and to study the three burial inventories found in that tomb. Comparing the physical textile remains against the burial inventories from the same tomb offered us a rare opportunity to test the accuracy of the burial inventories, and also to identify the physical textile remains with the textile terminology of that time. This article is arranged in four parts which present a brief description of the tomb, details of the burial inventories, a comparison of the textile remains against the burial inventories and a closer look at the silk textiles found in the tomb.
Managing a Multicurrency System in Tang China: The View from the Centre
Authors: XU CHANG , WANG HELEN
Published: July 2013

When the Tang dynasty took power in 618, it inherited the multicurrency system of earlier dynasties. The zuyongdiao tax system, in effect from the start of the dynasty, required each taxpayer to submit taxes in grain, labour and cloth. At the same time, the government also minted coins, which constituted some 10 per cent of the total money supply. A persistent shortage of copper limited the number of minted coins the government could issue. Accordingly, officials tried to ensure that sufficient coins and textiles circulated so that both forms of money remained in use. They displayed no consistent preference for one form of money over the other but devised policies to encourage the use of whichever form was then in short supply.