bluuebunny/crossref_metadata_2025 huggingface dataset:
Multicalorics --- new materials for energy and straintronics (R e v i e w)
Authors: Amirov A.A.  , Tishin A. M.  , Pakhomov O.V.
Published: September 2022

The terms "multicaloric effect" and "multicaloric" are relatively new concepts and combine the phenomena and materials associated with the coexistence of conventional caloric effects under the action of external forces of various nature (magnetic field, electric field, mechanical action). Nowadays, caloric materials remain in the focus of attention of researchers, and approaches based on the use of the multicaloric effect are considered as one of the ways to improve the efficiency of conventional solid-state cooling systems. Of particular interest from a fundamental point of view are the cross effects observed under the combined external stimulus, as well as the nature of the relationship between magnetic, electrical, thermophysical properties and structure under such actions. In this review, the theoretical foundations of the multicaloric effect are considered and an attempt is made to systematize multicaloric materials. Applied aspects of multicalorics are considered separately, and various experimental approaches to the study of their properties are presented. The presented review will be of interest to a wide range of specialists involved in the study of materials with caloric effects (magnetocaloric, electrocaloric, mechanocaloric), as well as those who are searching for new functional materials. Keywords: magnetocaloric effect, electrocaloric effect, elastocaloric effect, barocaloric effect, multicaloric effect, multiferroics, multicalorics, magnetoelectric composites.
Electronic, dielectric properties and charge transfer in a TlGaS-=SUB=-2-=/SUB=- : Nd-=SUP=-3+-=/SUP=- single crystal at direct and alternating current
Authors: Mustafaeva S.N.  , Asadov M.M.  , Guseinova S.S.  , Dzhabarov A.I.  , Lukichev V.F.
Published: September 2022

The band structure, density of states, and electronic properties of a 32-atomic supercell of a semiconductor compound TlGaS2 containing neodymium are calculated. On the grown new single crystals of TlGaS2 : Nd3+ (0.3 mol% Nd2S3), experimental results on the physical properties have been obtained. The temperature (93-538 K) and frequency (5·104-3.5·107 Hz) dependences of the dc and ac conductivity and the frequency dispersion of the dielectric coefficients of TlGaS2 : Nd3+ single crystals have been studied. It was found that in TlGaS2 : Nd3+, in the entire studied frequency range, there are losses due to electrical conductivity, and the charge transfer has a hopping character. The parameters of localized states are estimated, such as the density of localized states near the Fermi level and their spread, the average hopping time and distance, and the concentration of deep traps responsible for the dc and ac conductivity in TlGaS2 : Nd3+. Keywords: DFT calculation, TlGaS2 supercell, neodymium doping, energy structure, density of states, dielectric properties, charge transfer, TlGaS2 : Nd3+ single crystal, direct and alternating current.
Influence of sintering temperature on grain size and electrocaloric effect of barium titanate ceramics
Authors: Starkov I. A.  , Anokhin A. S.  , Mylnikov I. L.  , Mishnev M. A.  , Starkov A. S.
Published: September 2022

A theoretical study of the polarization distribution and mechanical stresses in a ferroelectric ball located in an unlimited dielectric space has been carried out. The ball is covered with a dielectric and air shell. The external electric field far from the ball is assumed to be uniform. The polarization in the ball satisfies the nonlinear Landau--Ginzburg equation, which takes into account the presence of electrostriction. It is also assumed that for a small ball, the effect of local elastic stresses on polarization can be replaced by their homogenized value over the volume of the ball. Under this assumption, the distribution of the stress and the electric field can be obtained both in the ball and outside it. The dependence of the Curie--Weiss temperature on the radius of the ball is derived. The resulting solution is used to simulate the properties of microgranular ceramics. Along with the developed theoretical model, a series of experiments was carried out to measure the temperature dependence dielectric constant and the electrocaloric effect (ECE) for BaTiO3 ceramics synthesized at different temperatures. The change in temperature during ECE was measured by direct methods. The greatest value of the ECE was achieved for ceramics synthesized at 1350oC. The magnitude of the change in temperature with a change in the electric field by 2 mV/m was Delta T=0.42 K. The observed experimental results demonstrate the possibility of using the theoretical four-phase model of ceramics to predict the dependence of the properties of ceramics on the sintering temperature. Keywords: ferroelectrics, electrocaloric effect, barium titanate (BaTiO3), granular media, sintering temperature, grain size.
Medical Staff and Resident Preferences for Using Deep Learning in Eye Disease Screening: Discrete Choice Experiment
Authors: Lin Senlin , Li Liping , Zou Haidong , Xu Yi , Lu Lina
Published: September 2022

Background

Deep learning–assisted eye disease diagnosis technology is increasingly applied in eye disease screening. However, no research has suggested the prerequisites for health care service providers and residents willing to use it.

Objective

The aim of this paper is to reveal the preferences of health care service providers and residents for using artificial intelligence (AI) in community-based eye disease screening, particularly their preference for accuracy.

Methods

Discrete choice experiments for health care providers and residents were conducted in Shanghai, China. In total, 34 medical institutions with adequate AI-assisted screening experience participated. A total of 39 medical staff and 318 residents were asked to answer the questionnaire and make a trade-off among alternative screening strategies with different attributes, including missed diagnosis rate, overdiagnosis rate, screening result feedback efficiency, level of ophthalmologist involvement, organizational form, cost, and screening result feedback form. Conditional logit models with the stepwise selection method were used to estimate the preferences.

Results

Medical staff preferred high accuracy: The specificity of deep learning models should be more than 90% (odds ratio [OR]=0.61 for 10% overdiagnosis; P<.001), which was much higher than the Food and Drug Administration standards. However, accuracy was not the residents’ preference. Rather, they preferred to have the doctors involved in the screening process. In addition, when compared with a fully manual diagnosis, AI technology was more favored by the medical staff (OR=2.08 for semiautomated AI model and OR=2.39 for fully automated AI model; P<.001), while the residents were in disfavor of the AI technology without doctors’ supervision (OR=0.24; P<.001).

Conclusions

Deep learning model under doctors’ supervision is strongly recommended, and the specificity of the model should be more than 90%. In addition, digital transformation should help medical staff move away from heavy and repetitive work and spend more time on communicating with residents.
Non-steroidal Anti-Inflammatory Drugs as protective Factor in Alzheimer's Diseases: a Systematic Review and Meta-Analysis Protocol (Preprint)
Authors: Asthana Akash , Tripathi Shashank , Agarwal Rachna
Published: September 2022

BACKGROUND

NSAIDs inhibit COX-2, which is responsible for regulating neurons leading to neurodegeneration in AD. AD is a neurodegenerative disease affecting the geriatric population, as it affects more than two third cases of dementia in the sphere. Results obtained from experimental and observational studies were unclear regarding the protective role of NSAIDs in AD, therefore this justifies the need for Meta-analysis.

OBJECTIVE

1) Role of NSAIDs, as a protective factor for AD in Experimental study design
2) Role of NSAIDs, as a protective factor for AD in Cohort study design
3) Role of NSAIDs, as a protective factor for AD in Case-Control study design

METHODS

Database search was PubMed, WebScience, and Embase. Experimental studies and Observational studies investigating the effect of NSAIDs on AD. For experimental studies indicators used were MMSE score, ADAS-cog score, CDR-sob score, NPI score, and Hazard ratio. Similarly for Observational studies, Odds Ratio and Relative Risk are used.

RESULTS

As the study is still ongoing, therefore it is not possible to write its results at this stage. There is a total of 06 (MMSE, ADAS-cog, CDR-sob, HR, RR, and OR) indicators used in the ongoing study, so 06 results will be obtained showing the pooled effect size which may indicate the use of NSAIDs as a protective factor for Alzheimer’s disease

CONCLUSIONS

Conclusion can be drawn only after the final meta-analysis using three study design (RCT, Cohort and Case-control study designs) and six indicators.

CLINICALTRIAL

PROSPERO [CRD42022301179]
prospero (crd42022301179)
Mechanisms of action of cytoplasmic microRNAs. Part 3. TNRC6-associated mechanism of miRNA-mediated mRNA degradation
Authors: Abaturov A.E. , Babуch V.L.
Published: September 2022

The scientific review presents the mechanisms of action of cytoplasmic miRNAs, namely posttranscriptional silencing: the TNRC6-associated mechanism of miRNA-mediated mRNA degradation. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka. It is known that in the cytoplasm of cells in cases of short region, miRNA complementarities cause posttranscriptional silencing, using the first of the main molecular mechanisms: the TNRC6-associated mechanism of miRNA-mediated mRNA degradation. Mammalian AGO proteins have been shown to contain the conserved m7G-cap-binding protein motif (known as the MID domain), which is required to induce microRNA-mediated translation repression. After binding of this AGO motif to microRNAs, TNRC6 proteins (GW182) are recruited that, in turn, recruits various proteins (PABPC1, PAN3 and NOT1) involved in the induction of the target gene silencing. The authors state that tryptophan residues, which are placed in the hydrophobic pockets of TNRC6 protein partners, cause a high degree of affinity and specificity of interactions. Scientists believe that the TNRC6 protein when interacting with AGO proteins can simultaneously use three GW/WG repeats (motif 1, motif 2 and hook motif), which are located in the Argonaute-binding domain. Therefore, the TNRC6 protein can bind to three AGO molecules simultaneously. TNRC6 proteins are known to be PABP-interacting proteins whose interaction with PABP is mediated by conservative PABP-binding motif 2. TNRC6 proteins have been shown to interact with the cytoplasmic PABPC1 protein during mRNA translation and stabilization. It is shown that the CCR4-NOT protein complex is a highly conserved multifunctional multiprotein formation having 3’-5’-exoribonuclease activity, due to which it controls mRNA metabolism. Thus, the TNRC6-associated mechanism of miRNA-mediated mRNA degradation in the cytoplasm of the cell causes posttranscriptional silencing. In this mechanism, there is an interaction of TNRC6 with PABPC1 protein, recruitment of deadenylating complexes PAN2-PAN3 and CCR4-NOT by the TNRC6 proteins.
Double Blackness in Tayeb Salih’s Season of Migration to the North: A Critical Discourse Analysis
Authors: Osman Dr. Osman Hassan , Abuoaf Dr. Mahmoud , Alnwairan Dr. Met'eb Ali
Published: September 2022

This paper examines the idea of double blackness and its role in constructing the Sudanese social hierarchy in Tayeb Salih’s Season of Migration to the North (1969). The article draws on several core concepts in postcolonial and anthropological studies, including race, culture, ethnicity, and Otherness. Instead of tackling the novel from the traditional postcolonial perspective, the paper adds an anthropological lens to the novel’s social dynamics to shed light on some neglected aspects like the multiplicity of Sudanese racial identity and its subsequent self-awareness. The discussion we present in this paper poses some problematic questions about the meaning of blackness and the presence of multiple layers of the Black Self in Sudanese society. Away from the postcolonial implications of the novel, we argue that Salih makes use of the traditional colonial discourse of self vs other and holds a mirror up to the Sudanese society itself. The novel shows that even among African communities where blackness is a norm, blackness and race remain major triggers of polemics and controversies in a very similar manner to what occurs in Western contexts. The new reading of the novel we propose is one that considers the ways in which characters from an “African” origin endure what we call “double Blackness” — the degradation experienced through both discourses of racism and social stratification.
DBRepo: a Semantic Digital Repository for Relational Databases
Authors: Weise Martin , Staudinger Moritz , Michlits Cornelia , Gergely Eva , Stytsenko Kirill , Ganguly Raman , Rauber Andreas
Published: September 2022

Data curation is a complex, multi-faceted task. While dedicated data stewards are starting to take care of these activities in close collaboration with researchers for many types of (usually file-based) data in many institutions, this is rarely yet the case for data held in relational databases. Beyond large-scale infrastructures hosting e.g. climate or genome data, researchers usually have to create, build and maintain their database, care about security patches, and feed data into it in order to use it in their research. Data curation, if at all, usually happens after a project is finished, when data may be exported for digital preservation into file repository systems.
We present DBRepo, a semantic digital repository for relational databases in a private cloud setting designed to (1) host research data stored in relational databases right from the beginning of a research project, (2) provide separation of concerns, allowing the researchers to focus on the domain aspects of the data and their work while bringing in experts to handle classic data management tasks, (3) improve findability, accessibility and reusability by offering semantic mapping of metadata attributes, and (4) focus on reproducibility in dynamically evolving data by supporting versioning and precise identification/cite-ability for arbitrary subsets of data.
Revisión de la naturaleza jurídica del prepuesto público. Desarrollo progresivo y nuevas tendencias
Authors: De La Guerra Eddy
Published: September 2022

El presupuesto es instituto jurídico que constituye una categoría compuesta, cuyo contenido mínimo, naturaleza y alcance, ha de ser determinado tanto por el desarrollo que la doctrina en varias ramas del Derecho Público ha esbozado, como por la relación directa con la Ciencia de las Finanzas Públicas. Este artículo parte de la historia y visiones clásicas sobre el presupuesto y pretende establecer una concepción moderna e interdisciplinaria, compatible con los nuevos modelos de Estado y de gestión pública.
Comentario al amparo directo: 164/2017 resuelto por Tribunal Colegiado del Trigésimo Segundo Circuito
Authors: Polanco Polanco Adrián
Published: September 2022

La resolución que se analiza se centra en las secuelas extra procesales de la figura de la cosa juzgada en materia civil y su impacto en el procedimiento penal, Estableceremos los prolegómenos metafísicos de la cosa juzgada en su reglamentación positiva penal mexicana, parece ser una pretensión alcanzable para esta investigación, la cual tiene por objeto principal, delimitar de forma adecuada la cosa juzgada en materia penal, deslindándola de su similar en materia civil.
Liminar
Authors: Fernández Ruiz Jorge
Published: September 2022

Presentación del contenido del número 283, en su secciones de Doctrina, Análisis de Legislación, Análisis de Jurisprudencia, Documentos, Reseñas y Obituario.
Hacia una nueva Ley Orgánica del Poder Ejecutivo Federal: Reforma Administrativa y Austeridad Republicana
Authors: Sandoval Ballesteros Irma Eréndira
Published: September 2022

Desde la entrada en vigor de la actual Ley Orgánica de la Administración Pública Federal, se han generando múltiples duplicidades y diversos vicios administrativos que han producido un gobierno obeso y con costos inmoderados. Por lo que, ante la necesidad de una reforma administrativa que desburocratice la Administración Pública en México, el artículo propone, una nueva organización del Poder Ejecutivo Federal, aunado a la creación de la Ley Orgánica del Poder Ejecutivo Federal (LOPEF) que sustituya a la vigente Ley Orgánica de la Administración Pública Federal, generando una Administración Pública Federal moderna, austera y democrática, con un manejo más equitativo y racional del presupuesto sustentado en la Austeridad Republicana.
Pruebas presuntivas y confirmatorias de sangre: enseñanza de la química en la hematología forense
Authors: Figueroa Martínez Francisco , Martínez Romero Valeria Elena , Villavicencio Queijeiro Alexa
Published: September 2022

Una de las disciplinas de la Ciencia Forense que se centra en el estudio de los fluidos y materiales biológicos es la Hematología y Serología Forense. Ésta puede ayudar a responder preguntas como ¿Se trata de un fluido biológico de interés forense?; ¿Es de origen humano?; ¿Cómo se depositó el fluido en el lugar de investigación o “escena del crimen”?; todas ellas preguntas relevantes antes de enviar una muestra a análisis genéticos para finalmente identificar a quién pertenece dicho fluido biológico. Cada una de estas preguntas se puede responder mediante el uso de diversas pruebas y análisis, específicamente mediante pruebas presuntivas y confirmatorias. Aunque existen diversas pruebas, el fundamento de todas se centra en la presencia del grupo prostético de la hemoglobina (grupo hemo) y las reacciones en las que este grupo puede participar. El tema de pruebas presuntivas y confirmatorias es un punto de salida, en el marco de la primera modificación al Plan de estudios de la LCF para discutir sobre la pertinencia de los temas a seleccionar en los cursos de química considerando el perfil profesional de los egresados.

 
Intrusion Detection System of IPv6 Network
Authors: B N Mangalagowri , Varma Dr. N. Sandeep
Published: September 2022

Abstract: There are variations within the network of the differential computing system's underlying IPv6 network. There are different blind zones for security detection. It is thoroughly investigated how the automatic data processing system differs from the underlying IPv6 network. An enhanced underlying IPv6 network security detection module design approach is suggested for the multicomputer system based on this concept. One gets the comprehensive module design plan. The new technologies like receiving thread domain, object forwarding domain, and file buffer are taken into account by the network security detection system. It can alleviate the challenges with security detection brought on by IPv6 network variations in the underlying computing system. Thus, IPv6 networks have a significantly lower number of blind zones.
E-Commerce Customer Segmentation Using Machine Learning
Authors: Babu Gali Venkata Durga Ayyappa , Sathish M Durga
Published: September 2022

Abstract: Splitting a client base into groups about people certain are similar in particular areas, such as age, gender, interests, & spending patterns as well as technique about grouping consumers about a corporation into categories certain demonstrate commonality among customers in each category. In order to optimise each customer's worth to business, segmenting clients is done in order to select how to interact among them. Client segmentation belongs to the specific strategy used by businesses to target particular, smaller groups about customers among appropriate messages certain would encourage them to make a purchase. aforementioned strategy is based on idea certain every customer is unique. among aim about learning what each client segment values most & better targeting their marketing efforts, businesses also aspire to better understand preferences & demands about their customers. In order to segment customers into targetable groups, it discover important differentiators certain separate them. Information used to determine segmentation strategies, such as a demo graph about consumers.
Pendugaan Erosi pada Pengelolaan Lahan Sistem Agroforestri Di Sub Das Amprong, Desa Gubugklakah, Kecamatan Poncokusumo, Kabupaten Malang
Authors: Waskitho Nugroho Tri , Ramadhan Ramli , Rahawan Prakasa Adi Dya
Published: September 2022

Sistem agroforestri juga mengusahakan agar tercipta struktur pelapisan tajuk yang serapat mungkin tanpa mengurangi persaingan unsur hara dan sinar matahari antar sesama vegetasi. Tujuan dari penelitian ini yaitu, Mengetahui jumlah besaran erosi pada sistem pengelolan lahan berbasis Agroforestri di sub DAS amprong desa gubugklakah kecamatan Poncokusumo, Kabupaten Malang. Penelitian ini dilaksanakan pada bulan April  s/d Juni   2020 yang dilaksanakan di Desa Gubugklakah Kecamatan Poncokusumo, Kabupaten Malang. Metode yang digunakan dengan mengetahui beberapa metode untuk memperkirakan besarnya erosi permukaan, metode Universal Soil Loss Equation (USLE). Data yang digunakan yaitu data primer dan daa sekunder. Data primer yang diperoleh langsung di lapangan yaitu pengambilan sampel tanah, di sub DAS Amprong di desa gubugklakah kemudian dianalisis di laboratorium. Data yang diperoleh dari berbagai instansi terkait LMDH dan BMKG yang diperlukan sebagai data penunjang dalam penelitian ini, seperti keadaan topografi, luas wilayah, keadaan biofisik, lokasi, tanah, dan iklim. Total nilai erosi ton/ha/tahun yang terjadi pada lahan Sub DAS Amprong yang terbesar pada plot 1 tanaman wortel memiliki nilai 1,47 ton/ha/tahun. Sedangkan nilai sedikit pada plot 3 tanaman kacang panjang memiliki nilai yaitu 0,24 ton/ha/tahun. Nilai erosi yang tertoleransi paling besar pada plot 1 memiliki nilai 31,23 ton/ha/tahun. Erosi yang terjadi pada plot 2 campuran pinus dan tanaman jahe, sereh, bawang prei memliki nilai 0,77 ton/ha/tahun. Sedangkan nilai erosi yang terjadi pada plot 4 campuran pinus dan cabai keriting memiliki nilai 0,47 ton/ha/tahun.Sedangkan erosi tertoleransi paling sedikit pada plot 2,3dan 4 tanaman kacang memiliki nilai yaitu 29,07 ton/ha/tahun. Indeks bahaya erosi tinggi besar pada plot 1 yaitu 0,04 dengan jenis tanaman wortel termasuk kategori bahaya erosi tinggi, sedangkan tingkat bahaya erosi yang rendah pada plot 3 yaitu 0,008 dengan jenis tanaman kacang panjang termasuk kategori bahaya erosi rendah.
Pondering on the ways to enhance university reputation
Authors: Ebzeeva Yulia N. , Dugalich Natalia M.
Published: September 2022

The article describes positive experience of the Peoples’ Friendship University of Russia (RUDN University), which has risen significantly in QS World University Rankings, both in the overall assessment and in the subject ranking. The authors provide factual material and give recommendations for a step-by-step strategy for reorganising educational and scientific activities of the university with a view to increasing the quality of education services, which include the allocation of priority areas; application of new forms of work; development of image strategies in the field of scientific activity and cooperation with employers. The study is based on the analysis of the methodology of the world’s leading rankings. It also focuses on the implementation of the road map of RUDN University and other Russian universities. To reveal best practices, the authors break down the activities of RUDN University while implementing the 5-100 programme and other activities with a view to promoting the university in international university rankings and enhancing its reputation. Study results suggest that the most important steps in determining the direction in the development of the university are the selection of priority areas of activity, organisation of new forms of work, the attraction of leading international and Russian scientists in a certain field of activity for cooperation, the support and development of scientific projects, cooperation with scientific, educational, practical and industrial organisations in Russia and the world, development and implementation of a number of image strategies in the field of scientific activity, and working with employers to organise internships and further employment of university graduates.
GAYA HIDUP MINIMALIS SEBAGAI PENGAMALAN ILMU ESKATOLOGI DALAM MENGINGAT HARI AKHIR DAN AKHIRAT
Authors: Putri Rahmadila Dania , Wasik Abdul
Published: September 2022

Eschatology is part of theology that discusses the last days, in Islamic teachings eschatology is closely related to the faith of a Muslim in the last days. And for a Muslim faith must be in line with the existence of evidence in the form of practice in everyday life that reflects an eschatology or faith in the last days. The practice of a science is very important because it will provide many benefits and significant developments for human life. Actually, there are many ways to practice and imply faith in the hereafter and eschatology, one of which is living a minimalist life. Then how can a minimalist life be said to be a practice of eschatology in remembering the last days or the afterlife. In this article, we will discuss this matter using qualitative research methods, in the form of literature review and literature study. The results of this study show that minimalist living can be used as the practice of eschatology in remembering the afterlife, because minimalist life is basically similar to qanaah and zuhud life, both of which focus on the afterlife. It also turns out that a minimalist life has been recommended from the beginning in Islamic teachings, namely living as simply as possible and not exaggerating in pursuing the world, and increasing practices to improve the quality of the afterlife.AbstrakIlmu eskatologi merupakan bagian dari ilmu teologi yang membahas mengenai hari akhir, pada ajaran Islam ilmu eskatologi erat kaitannya dengan keimanan seorang muslim kepada hari akhir. Dan bagi seorang muslim keimanan itu harus sejalan dengan adanya pembuktian berupa pengamalan dalam kehidupan sehari-hari yang mencerminkan suatu ilmu eskatologi atau keimanan pada hari akhir. Pengamalan suatu ilmu sangat penting karena akan memberi manfaat yang banyak dan perkembangan yang signifikan bagi kehidupan manusia. Sebenarnya banyak cara dalam mengamalkan dan mengimplikasikan iman kepada hari akhir dan ilmu eskatologi, salah satu diantaranya adalah hidup minimalis. Lalu bagaimana bisa hidup minimalis dikatakan sebagai sebuah pengamalan ilmu eskatologi dalam mengingat hari akhir ataupun alam akhirat. Pada artikel ini akan dibahas mengenai hal tersebut dengan menggunakan metode penelitian kualitatif, berupa kajian pustaka dan studi literatur. Hasil dari penelitian ini ternyata hidup minimalis bisa digunakan sebagai pengamalan ilmu eskatologi dalam mengingat akhirat, karena hidup minimalis pada dasarnya mirip dengan qanaah dan hidup zuhud, dimana sama-sama memfokuskan diri untuk kehidupan akhirat. Juga ternyata hidup minimalis memang sudah dianjurkan dari dahulu pada ajaran islam, yaitu hidup sesederhana mungkin dan tidak berlebih-lebihan dalam mengejar dunia, serta memperbanyak amalan untuk meningkatkan kualitas kehidupan akhirat.
Capturing experimental properties in computationally efficient faceted titania nanoparticle models
Authors: Repa Gil , Fredin Lisa
Published: September 2022

Understanding the surface chemistry of nanostructured TiO2 has long been
a priority to improve photochemical device efficiency. Faceted
nanoparticles, characterized by known facets not at thermodynamically
ideal ratios, are particularly challenging to model due to the large
number of chemical and computational parameters that must be chosen for
which there is no experimental guidance. This research supplies a
modeling framework for faceted TiO2 nanoparticles that provides
rationale for such decisions. By performing full DFT optimization and
characterization on a series of inter-related anatase TiO2 nanoparticles
displaying {101}, (001), and {010} facets with sizes up to 202 TiO2
units, parameter space is mapped with regard to particle size, shape,
defects, and optimization protocol. Specifically, it is shown that
pre-optimization is necessary in order to achieve a sufficiently
delocalized electronic structure, and the increased reorganization
afforded by removing higher coordinated Ti atoms compensates the high
formation energy of creating these defects. Furthermore, by
characterizing differently shaped nanoparticles with the same number of
TiO2 units, this research provides direct observation of shape effects
on nanoparticles.
Exome sequence identifies a cryptic chromosome translocation in a family decades after clinical diagnosis of Cornelia de Lange: case report
Authors: Sekhon Morgan , Brown Stephen
Published: September 2022

We present a family in which the recent birth of a baby resulted in the
establishment of a cytogenetic diagnosis of a different family member
whose initial evaluation and clinical diagnosis had occurred three
decades earlier. The new genomic findings have profound implications for
other family members.
A case of Candida parapsilosis bioprosthetic valve endocarditis
Authors: Sakakibara Kenji , Nakajima Hiroyuki
Published: September 2022

Fungal bioprosthetic valve endocarditis is regarded as a rare, fatal
disease. Severe aortic valve stenosis due to vegetation in bioprosthetic
valves was also rare. Because biofilm formation is a factor related to
persistent infection, the best outcomes for endocarditis are achieved in
patients treated surgically with concomitant antifungal medications.
Intraosseous Lipoma of Calcaneum: A Rare Incidental Finding
Authors: Lamichhane Bishesh , LAMICHHANE SARAL , Shah Roshan , Yadav Mamata , Pant Sujata
Published: September 2022

Intraosseous lipoma is a rare benign lesion of bone. We present a case
of an intraosseous lipoma of the calcaneum detected as an incidental
finding, as well-delineated osteolytic lesion with central area of
calcification, on plain radiography. Diagnosis can be done with a
computed tomography scan and/or magnetic resonance imaging.
Prognostic factors registered on admission to the hospital related to mortality risk in cancer patients with COVID-19: a retrospective cohort study
Authors: Szewczyk-Dąbrowska Alina , Banasik Mirosław , Dąbrowska Krystyna , Kujawa Krzysztof , Bombala Wojciech , Sebastian Agata , Matera-Witkiewicz Agnieszka , Krupińska Magdalena , Grata-Borkowska Urszula , Sokołowski Janusz , Kiliś-Pstrusińska Katarzyna , Adamik Barbara , Doroszko Adrian , Kaliszewski Krzysztof , Pomorski Michał , Protasiewicz Marcin , Jankowska Ewa , Madziarska Katarzyna
Published: September 2022

Background: Cancer patients are a particularly vulnerable risk group of
the severe course of COVID-19 due to, i.e. suppression of the immune
system. The study aimed to find links between parameters registered on
admission to the hospital, and the risk of latter death in oncology
patients with COVID-19. Design: Retrospective cohort study. Methods: The
study included patients with a reported history of malignant tumor
(N=151) and the control group with no history of cancer (N=151)
hospitalized due to COVID-19 between March 2020 and August 2021. The
variables registered on admission were divided into categories for which
we calculated the multivariate Cox proportional hazards models. Results:
The median age of the study group was 68 years (min-max: 17-95). 50.33%
(76/151) were women. Multivariate Cox proportional hazards models were
successfully obtained for the following categories: Patient data,
Comorbidities, Signs recorded on admission, Medications used before
hospitalization and Laboratory results recorded on admission. With the
models developed for oncology patients, we identified the following
variables that registered on patients’ admission were linked to
significantly increased risk of death: male sex, presence of metastases
in neoplastic disease, impaired consciousness (somnolence or confusion),
wheezes/rhonchi, the levels of white blood cells and neutrophiles.
Conclusion: Identifying the predictors of a poorer prognosis may serve
clinicians in better tailoring treatment among cancer patients with
COVID-19. Our results can help develop prognostic models or compare the
results of other studies, which will translate into better treatment
management and better prognosis in this group of patients.
Changes to the trophic structure of a desert fish community following river regulation and species turnover: implications for an endangered top predator
Authors: Gilbert Eliza I. , Franssen Nathan
Published: September 2022

A poor understanding of factors leading to species decline can result in
inefficient or ineffective species restoration. Endangered Colorado
Pikeminnow ( Ptychocheilus lucius) was nearly extirpated from the
San Juan River, NM, USA and recent efforts to reestablish the species
via hatchery augmentation of juveniles has yet to reach the targeted
number of adults in the system. To assess how changes to the river’s
food web could be limiting reestablishment of this top predator, we used
stable isotope (δ C and δ N)
signatures of the fish community pre- (museum specimens) and post river
regulation with coincident extirpations and invasions. Following river
regulation, four of five community-wide trophic structure metrics used
to quantify resource use diversity were reduced and species turnover
likely had little effect per se. For species sampled in both time
periods, shared trophic resources generally increased (mean niche
overlap = +35.7%). However, Colorado Pikeminnow experienced a large
decrease in niche breadth (-72%) and diet mixing models suggested a
shift from piscivory towards insectivory in contemporary collections.
Our results suggested an overall reduction in basal resource
availability after river regulation. We suggest increased reliance on
similar resources may be limiting fish prey for Colorado Pikeminnow,
ultimately contributing to the slow and limited reestablishment in the
San Juan River. This study adds to the growing body of knowledge
provided by museum specimens and stable isotope analyses to identify
food-web dynamics that are a departure from historical conditions which
can provide novel information critical to imperiled species management
in modified systems.
Wound myiasis resulting from a neglected insect bite wound.
Authors: Suryabanshi Anil , Timilsina Binita , Khadka Namrata
Published: September 2022

Infestation of maggots in humans is rare because human is an accidental
hosts for many dipterous larval species. We present a case of wound
myiasis in a homeless person that resulted from a neglected minor insect
bite wound.
Phylogenetically-conserved candidate genes unify biodiversity-ecosystem function relationships and eco-evolutionary dynamics across biological scales
Authors: Blanchet Simon , Fargeot Laura , Raffard Allan
Published: September 2022

The intra- and interspecific facets of biodiversity have traditionally
been quantified and analysed separately, limiting our understanding of
how evolution has shaped biodiversity, how biodiversity (as a whole)
alters ecological dynamics, and hence eco-evolutionary feedbacks at the
community scale. Here, we propose using candidate genes
phylogenetically-conserved across species and sustaining functional
traits as an inclusive biodiversity unit transcending the intra- and
interspecific boundaries. This framework merges knowledge from
functional genomics and functional ecology, and we first provide
conceptual and technical guidelines for identifying
phylogenetically-conserved candidate genes (PCCGs) within communities,
and for measuring inclusive biodiversity from PCCGs. We then explain how
biodiversity measured at PCCGs can be linked to ecosystem functions,
which may unify recent observations that both intra- and interspecific
biodiversity are important for ecosystem functions. We then highlight
the eco-evolutionary processes shaping PCCGs diversity patterns, and
argue that their respective role can be inferred from concepts derived
from population genetics. Finally, we explain how PCCGs may shift the
field of eco-evolutionary dynamics from a focal-species approach to a
more realistic focal-community approach. This framework provides a novel
perspective to investigate the global ecosystem consequences of
diversity loss across biological scales, and how these ecological
changes further alter biodiversity evolution.
Percepción del estilo parental y calidad de vida relacionada con la salud entre adolescentes
Authors:   Universidad Internacional de la Rioja, Jódar Martínez Rosalía , Martín Chaparro María del Pilar ,   Universidad de Murcia, Hidalgo Montesinos María Dolores ,   Universidad de Murcia, Martínez Ramón Juan Pedro ,   Universidad de Murcia
Published: September 2022

The interaction between health-related quality of life and parenting styles can give rise to perceptions that influence behaviour in adolescents. It is thought to affect key el- ements in the emotional development of stu- dents at a very important stage. Therefore, the aim of this study was to explore the re- lationship between health-related quality of life and perceived parental educational style as a function of parental gender. A total of 253 adolescents aged 11 and 18 years were selected from secondary schools in a region of south-eastern Spain. The Scale of Norms and Demands Children’s Version (ENE-H by its Spanish acronym) and the Short Form-36 Health Survey (SF-36) were used. This was a quantitative research project and data mining was used for data analysis. The results showed that the inductive parenting style is related to physical role, emotional problems, vitality, emotional well-being, pain and general health. We also observed that the rigid style is neg- atively related to physical role, vitality, emo- tional well-being, social functioning, pain and general health. Finally, the indulgent style is negatively related to pain. The findings shed light on the need to provide health-related training programmes that consider family characteristics.
New Evidence-Based Therapies for Complex Diabetic Foot Wounds
Authors: Boulton Andrew , Armstrong David , Londahl Magnus , Frykberg Robert , Game Frances , Edmonds Michael , Orgill Dennis , Kramer Kimberly , Gurtner Geoffrey , Januszyk Michael , Vileikyte Loretta
Published: September 2022

This treatise includes reviews of both of these new therapies by members of our author group (F.L.G. and M.E.E.) who participated in the clinical trials of the respective agents. Additionally, the use of negative pressure wound therapy (NPWT), which is also supported by evidence from RCTs, is reviewed. The final two sections of this compendium explore putative new, evidence-based therapies for DFUs that are in the pipeline and, most importantly, how we might engage digital technology and other aids to facilitate the prevention of DFU recurrence.
Bio-Behavioral Changes Following Transition to Automated Insulin Delivery: A Large Real-Life Database Analysis
Authors: Kovatchev Boris P. , Singh Harsimran , Mueller Lars , Gonder-Frederick Linda A.
Published: September 2022

  

Objective: Document glycemic and user-initiated bolus changes following transition from predictive-low glucose suspend (PLGS) system to automated insulin delivery (AID) system during real-life use.

Research Design and Methods: Analysis of 2,329,166 days (6,381 patient-years) of continuous glucose monitoring (CGM) and insulin therapy data for 19,354 individuals with Type 1 Diabetes, during 1-month PLGS (Basal-IQ technology) use followed by 3-month AID use (Control-IQ technology). Baseline characteristics: 55.4 percent female, age (median/quartiles/range) 39/19-58/1-92 years, glucose management indicator (GMI) 7.5±0.8. Primary outcome: time in target range (TIR 70-180mg/dL). Secondary outcomes: CGM-based glycemic control metrics; frequency of user-initiated boluses.

Results: Compared to PLGS, AID increased TIR on average from 58.4 to 70.5 percent. GMI and percent time above/below target range improved as well, 7.5 to 7.1; 39.9 to 28.1 percent, and 1.66 to 1.46 percent, respectively, all p-levels <0.0001. Stratification of outcomes by age and baseline GMI revealed clinically significant differences. Glycemic improvements were most pronounced in those <18 years old (TIR improvement 14.0 percentage points), and those with baseline GMI >8.0 (TIR improvement 13.2 percentage points). User-initiated correction boluses decreased from 2.7 to 1.8 per day, while user-initiated meal boluses remained stable at 3.6 to 3.8 per day.

Conclusions: Observed in real life of over 19,000 individuals with type 1 diabetes, transitions from PLGS to AID resulted in improvement of all glycemic parameters, equivalent to improvements observed in randomized clinical trials, and reduced user-initiated boluses.  However, glycemic and behavioral changes with AID use may differ greatly across different demographic and clinical groups. 
THE INFLUENCE OF THE ORGANIZATION OF SOCIETY ON THE STATE OF THE ENVIRONMENT
Authors:   A. Podgorny Institute for Mechanical Engineering Problems NAS of Ukraine, Mykhaylenko Volodymyr , Antonov Oleksiy ,   A. Podgorny Institute for Mechanical Engineering Problems NAS of Ukraine
Published: September 2022

The article is aimed at researching the current problem of socioecology - the causes and consequences of possible resource depletion, as well as establishing the possibility of its averting. There are two classifications of natural resources from the point of view of ecology: according to their renewability and according to the possibility of use. Based on the concept of the Rouche limit, the law of the resource balance of society is formulated, which relates the social productivity of labor to the population density and the depletion of available natural resources. This law is another form of recording the balance of social production and consumption of resources. The consequences of its violation are shown.The effect of abiotic, biotic and anthropogenic factors on the rate of depletion of available natural resources is studied, and the decisive role of scientific and technological progress in the development of the resource base of society is shown. It was determined that scientific and technological progress is a decisive factor in averting a resource catastrophe by humanity and individual nations. The conducted study of the social structure allows us to draw a conclusion about the decisive role of industrial relations in the implementation of new scientific and technical solutions in production.
Financial Technology in Indonesia: Effect of Risk on Financial Performance in Peer-To-Peer Lending
Authors: Putri Bella Marcelina , Wibisono Handoyo
Published: September 2022

This study aims to acquire empirical evidence related to the effect of risk on financial performance in peer-to-peer lending in Indonesia. By exploring the financial statements throughout 2019-2020. The test uses a panel data regression model, the Common Effect Model as the selected estimation regression model. Financial risk is measured by Operating Income Operating Expenses (BOPO), Net Interest Margin (NIM), Loan to Deposit Ratio (LDR), Debt to Asset Ratio (DAR), Debt to Equity Ratio (DER), and Capital Adequacy Ratio (CAR). In contrast, financial performance is measured by Return on Assets (ROA) and Return on Equity (ROE). The results of this study showed that the solvency risk projected by DAR, DER, and CAR had proven to influence the profitability of peer-to-peer lending in Indonesia projected by both ROA and ROE.
A Review on the Structure, Application and Performance of the Passive Microstrip Devices
Authors: Rezaei Abbas , Yahya Salah I.
Published: September 2022

Microstrip technology is widely applied for design and implementation of several communication devices such as filters, diplexers, triplexers, multiplexers, couplers, etc. They are utilized to isolate desired signals and remove disturbing signals. The layout of filters, diplexers and triplexers have two, three and four ports, respectively. Passive filters have at least one pass channel, whereas diplexers have at least two channels to transmit the desired signal, and multiplexers have more passbands with more channels. In order to implement the passive components, first a cell called resonator must be designed. Creativity is very important in resonator design. It must be small and novel to get a better device than previous works. Therefore, the layout of previous reported resonator, used in passive microstrip devices, are studied in this work. There is a fierce competition among designers to miniaturize and increase the device performance. Hence we will investigate them, from the point of view size and performance, in this work. Some diplexers are multi-channel, which are more difficult to design than two-channel diplexers. Therefore, the multi-channel diplexers are less reported than the two-channel diplexers. The design of multiplexers is also very difficult because several channels must be controlled. Hence, they are less designed than filters and diplexers. The diplexers can be bandpass-bandpass or lowpass-bandpass, where the latest is less designed. This is because designing a lowpass-bandpass diplexer needs lowpass and bandpass resonators, whereas the design of a bandpass-bandpass diplexer needs only a bandpass resonator.
¿Será capaz el ser humano de madurar los avances de la ciencia?
Authors: Lucchetta Maria Clarisbel
Published: September 2022

En una visión ulterior, el ser humano ¿será capaz de capitalizar todos los adelantos científicos y tecnológicos? ¿Podrá aplicarla correctamente o derivara en contra de la humanidad? Aquí indefectiblemente debemos acercarnos a los valores éticos y morales que tiñen de colores el progreso de la ciencia. Diversos epistemólogos, filósofos han compartido manuscritos sobre el crecimiento del conocimiento en múltiples áreas científicas y la ética con la que se ven aplicados los mismos. En este trabajo se busca generar una reflexión de como el ser humano en función a la sociedad en la que existe, es capaz de razonar o madurar los cambios asociados a la ciencia y tecnología en función a los elementos que le fueron dados en la comunidad donde se produjo su desarrollo cognitivo. Comprender la forma en que el ser humano aplica la ciencia; para generar avances tecnológicos que mejoren la calidad de vida y para explorar nuevos mundos de conocimiento.
Estimación del factor de propagación R0 del COVID-19 por medio del modelo de Kermack-McKendrick
Authors: Viña Carmen Milagro , Pernalete Lugo Josefrank
Published: September 2022

El modelo epidémico SIR, es útil para medir la rapidez de propagación de la infección COVID-19 en términos de umbral epidemiológico R0 a lo largo del tiempo. Se desarrolló un modelo matemático diferencial ordinario para medir el comportamiento del COVID-19 en el Perú, partiendo de la experiencia en el control de infecciones Kermack–McKendrick. Se estimó además la tasa de infectados β y de recuperados o eliminados γ, haciendo uso del conjuntos de datos oficiales de la Organización Mundial de la Salud, partiendo del histórico entre el 07 de Marzo y el 24 de Septiembre de 2020 y; proyectado hasta el 28 de Octubre de 2021. Explicando que la menor tasa de infectados ocurrirá a partir del 30 de Junio de 2021 β=0,24. Evidenciando un pronóstico de erradicación para el 28 de Octubre de 2021 con una tasa de infectados (β=0,21) y umbral (R0=0,03), además se cuantificó la exactitud del modelo en 93,012%, con 6,988 % de error porcentual medio de mitigación COVID-19, siendo el valor promedio temporal R0 <1, así que cada persona que contrae la enfermedad infectará a menos de una persona antes de morir o recuperarse, por lo que el brote desaparecerá.

Palabras Clave: infectado; recuperado; propagación; mitigación: umbral epidemiológico.