bluuebunny/crossref_metadata_2025 huggingface dataset:
A Cerebelláris Kognitív-Affektív Szindróma Skála magyar nyelvű validációja
Authors: Szabó-Műhelyi Viktória , Bencsik Judit , Hegedűs Aletta , Borbély Csaba , Baross Júlia , Majer Réka , Varga Rita , Szabó Pál Tamás , Béres-Molnár Katalin Anna , Folyovich András
Published: May 2024

Bevezetés: A cerebelláris kognitív-affektív szindróma olyan
tünetegyüttest jelent, amely a motoros és végrehajtó funkciók zavarán túl a
memória, a váltás-gátlás, a konceptualizálás és az érzelem és viselkedés
szabályozásában is megnyilvánulhat. A szindróma felmérésére dedikált magyar
nyelvű mérőeszköz eddig nem állt a hazai szakemberek rendelkezésére.
Célkitűzés: A kutatás célja volt a Cerebelláris
Kognitív-Affektív Szindróma Skála (CCAS-H) magyar mintán történő validációja,
diagnosztikus érvényességének felmérése, valamint a teszt közzététele a
szakemberek számára. Módszer: Multicentrikus kutatási
elrendezésben, hat kórházi osztállyal való együttműködés keretében cerebelláris
érintettségű páciensekkel és kontrollszemélyekkel történtek tesztfelvételek
2021. 07. 12. és 2023. 12. 31. között. A statisztikai elemzések során
normalitástesztelést, leíró statisztikát, átlagok tesztelését,
korrelációszámításokat, valamint ROC-elemzést végeztünk,
Cronbach-alfa-értékeket, Cohen-féle kappát határoztunk meg. A normalitás
sérülése esetén robusztus próbákat választottunk. Eredmények:
54 cerebelláris és 40 kontrollszeméllyel történt tesztfelvétel, amelyekből
különböző alcsoportokat képeztünk. Mintánkban az életkor (r = –0,581***, df =
87, p<0,001) és az iskolázottság (r = 0,360***, df = 87, p<0,001)
szignifikáns együttjárást mutatott az összpontszámokkal. A CCAS-H megfelelő
belső konzisztenciájú (α = 0,771), teszt-reteszt vizsgálat alapján stabil (r =
0,793***, df =13, p<0,001), és megítélők közti 88,2%-os egyetértést mutatott
(𝜅 = 0,779, z = 4,79, p<0,001). A fals pozitív esetek csökkentése érdekében
a szindrómát előre jelző vágópontokat megemeltük, így 5 hibapontnál felmerül
(szenzitivitás: 100%, specificitás: 43,48%), 6 hibapontnál valószínű
(szenzitivitás: 90,91%, specificitás: 62,32%), 7 hibapontnál határozott
(szenzitivitás: 81,82%, specificitás: 73,91%) a szindróma előfordulásának
valószínűsége (AUC: 0,836). Megbeszélés: Az elemzések a
nemzetközi ajánlásoknak megfelelően készültek. Az eredeti és más validált
változatokhoz képest a magyar verzió nagyobb belső konzisztenciát mutatott. A
skála stabil és megbízhatóan alkalmazható, emellett ismertetjük a teszt adta
újabb kutatási kérdéseket. Következtetés: Az újonnan validált
skála alkalmas mérőeszköz a szindróma mérésére. Tanulmányunkkal elérhetővé
tettük a CCAS-H-t a magyar szakemberek számára. Orv Hetil. 2024; 165(20):
785–798.
Külföldre vihető gyógyszerek – adatbázis az utazás előtti tanácsadást végző szakemberek számára
Authors: Shmorgun Annamária , Mészáros Ágnes , Felkai Péter
Published: May 2024

A tömegturizmus nemzetközivé válásával és a megfizethető utaztatási technikák
kialakulásával több, nagy kockázatú utazó réteg alakult ki: ezek közül a
legsérülékenyebbek a multimorbid (általában idősebb) emberek és a krónikus
betegségben szenvedő utazók. Nekik rendszeres napi gyógyszerszedésre van
szükségük. A külföldre vihető gyógyszerek mennyisége és hatóanyag-tartalmuk
azonban szigorúan szabályozott, emiatt az utazás előtti tanácsot adó orvosoknak,
gyógyszerészeknek ezen a téren naprakész tájékozottsággal kell rendelkezniük. A
megfelelő adatbázishoz való hozzáférés lehetősége, annak használata azonban nem
ismert széleskörűen. Európában a schengeni határokon belül a gyógyszerek
kivitele és behozatala egységes szabályozás alá esik, de a szabályozás ezen
országokon kívül változó. Szükséges egy olyan adatbázis összeállítása, amely
segítséget nyújt a rendszeresen gyógyszert szedő utazók felkészítését végző
orvosoknak, egyrészt a jogszabályoknak megfelelő gyógyszermennyiség felírásában,
másrészt pedig a külföldre, a nemzetközi határokon átvihető és át nem vihető
gyógyszerekről való tájékozódásban. A szerzők a hozzáférhető nemzetközi és
országos adatbázisok felmérésével, a meglévő szabályozás áttekintésével a
hatóságok által összeállított adatbázison kívül – azt kiegészítve – új
adatbázist dolgoztak ki. A létrehozott adatbázis 15, a magyar utazók által
leggyakrabban választott úti cél adatait és szabályozásait dolgozza fel. A
krónikus betegségben szenvedő utazók gyógyszerkészletének összeállításakor a
létrehozott adatbázis információi elsőrendű fontosságúak, mert a nem
engedélyezett szerek külföldre való vitele a megfelelő adminisztratív feltételek
hiánya esetén a gyógyszer bevitelének megakadályozásán kívül komoly büntetőjogi
következményekkel is járhat. Ezért az utazási tanácsokat adó orvosoknak
ismerniük kell a szabályozásokat, mert az utazás előtti megfelelő tanácsadásnak
szerves részét képezi a megfelelő mennyiségű gyógyszerek felírása és a
gyógyszerelések úti célnak megfelelő módosítása. Orv Hetil. 2024; 165(20):
769–774.
How Cs-137 dispersions due to atmospheric deposition to East Vietnam Sea: a hypothetical level 7 incident from the Fangchenggang Nuclear Power Plant (China)
Authors: Vu Duy Vinh , Nguyen Minh Hai , Nguyen Trong Ngo , Tran Quang Thien
Published: May 2024

Only about 50 km from the Quang Ninh coastal area in Vietnam, the Fangchenggang Nuclear Power Plant (China) operation causes excellent concerns for the environment, especially the marine environment, if an incident occurs. Based on topographic and hydrometeorological data and assumptions about radiation release conditions when an incident occurs, the Delft3D-Part modeling system was set up to assess/forecast the effect of Cs-137 radioactive activity on the source of air deposition in the water environment of Vietnam. The results showed that the sources of the drop from the air significantly affected and caused a faster impact than direct radioactive sources after the incident. Under the influence of marine circulation, wind radioactive material after falling into the sea will quickly disperse and may affect the entire East Vietnam Sea after 3–6 months. The area with high radioactivity is concentrated mainly in the Tonkin Gulf and along the coast of Vietnam. Especially in the Gulf of Tonkin, the radioactivity can reach 300–1,200 Bq/m3 after the 5-day incident. The amount of radiation then gradually decreases to almost less than 100 Bq/m3 after one year and below 20 Bq/m3 after two years. According to depth, the amount of radioactive Cs-137 tends to shift between layers from the surface to the bottom: higher at first in the upper layers, then gradually decreasing and increasing in the lower layers. Radioactivity significantly reduced after two years of the incident but still exceeded QCVN 10: 2008/BTNMT.
Evaluating of the accuracy of the DTU22MDT mean dynamic topography model based on the tidal gauge data in Vietnam’s coastal areas
Authors: Bui Thi Hong Tham
Published: May 2024

In this study, the accuracy of the latest mean dynamic topography model (MDT), DTU22MDT, is determined based on data collected from 14 tide gauge stations along the coast of Vietnam, from the North to the South. The process of assessing the accuracy of the DTU22MDT model is carried out carefully and precisely, involving determining the model’s height at tide gauge stations, quality checks of the data, and evaluation of the model’s accuracy. The research results indicate that, compared to the local sea surface in Vietnam, the DTU22MDT model has a higher height of approximately 0.7 meters. This model represents the global MDT with the highest accuracy in Vietnam, with a mean square error of about 9.0 cm. This information provides a basis for applying the model in scientific research and practical applications, such as constructing a national height system, planning the economic development of coastal areas, generating specialized maps, designing structures, and other activities in the maritime regions of Vietnam. The method used to evaluate the accuracy of the MDT in this study can be applied to other research areas and to different MDTs.
With Climate Change, the Evolution of Ultra-Low Volume Spraying Needs to be a Part of Sustainable Pest Management
Authors: Matthews Graham
Published: May 2024

The impact of Climate Changes has become increasingly evident with rainfall causing flooding, even in areas regarded as arid in contrast to areas of Tropical forests. This is due to the increase in the temperature of the oceans, so more water is rising into the sky and ultimately this is falling as heavier rain. This consequently affects growing crops and how they can be protected from insect pests and diseases, as the rain can remove pesticides using a formulation that is mixed with water for spraying on crops.
Benefits of ULV Application to Control Locusts in Caucasus and Central Asia
Authors: Clayton J.S. , Gapparov F.A. , Latchininsky A.V. , Nurjonov F.A. , Duissembekov B.A.
Published: May 2024

This paper discusses the state-of-the-art of Ultra-Low Volume (ULV) spray application with rotary atomisers in the Caucasus and Central Asian (CCA) region to control locusts. The technology is widely used around the world for locust control and promoted by the UN Food and Agriculture Organisation (FAO) as an effective and efficient control intervention that meets the scale and challenge posed by large area locust outbreaks. The technology utilises precisely controlled spray droplets in the range 50–100um using ready-to-use oil-based ULV formulations to target locusts more efficiently. Volume rates as low as 0.5-1.0 l/ha are utilised which greatly improves productivity of ground and aerial spray applications, timeliness, and reduces cost and waste of pesticide and water. ULV has become more widely adopted in CCA during recent years to control major economic pests such as Moroccan, Italian, and Asian migratory locusts. Its further adoption is hampered by the lack of available ULV formulations in the region and need for investment and training in the technology. ULV technology is highly appropriate for use of biological products to reduce risks to operators and the environment and efforts to increase regional cooperation and the registration of safer pesticides across the region present opportunities for its wider adoption.
Mixtures of Herbicides and Time of Application to Control Commelina Benghalensis in Maize and Off-Season
Authors: Vicensi Tiago , Albrecht Leandro , Albrecht Alfredo , Silva André , Backes Maria , Mundt Tamara Thais
Published: May 2024

The objective was to evaluate the effectiveness of herbicides in mixtures with glufosinate in maize and the effect until soybean sowing. Also, to evaluate the effect of time of application on the effectiveness of these herbicides in the off-season. Experiment 1 was conducted in two areas planted with maize. Experiment 2, in the off-season, after maize harvesting and before soybean sowing. In experiment 1, the treatments consisted of the application of atrazine alone or mixed with glufosinate, glufosinate alone or mixed with s-metolachlor, atrazine/s-metolachlor, mesotrione, atrazine/mesotrione, tembotrione, terbuthylazine, carfentrazone and 2,4-D, in addition to the untreated control. In experiment 2, treatments were arranged in a 9 x 3 factorial design (herbicides x application times). Glufosinate alone or in mixtures with two doses of atrazine, s-metolachlor, mesotrione, atrazine/mesotrione, carfentrazone and 2,4-D were applied, in addition to the untreated control. The three application times were 20 h, 4 h and 12 h. Weed control was evaluated in both experiments, and maize agronomic performance in experiment 1. In general, greater efficiency was found for herbicide mixtures, especially for those with a combination of pre- and post-emergence effects. The herbicides did not affect the agronomic performance of maize in experiment 1. Regarding the time of application, no effect was detected on the action of the herbicides. Mixtures of herbicides are recommended for an effective control until soybean sowing, with emphasis on those with pre- and post-emergence effects on C. benghalensis, regardless of the time of application.
Religious and Cultural Embodiment in the Land of Osing: A Portrait of Hadrami Community in Banyuwangi, East Java
Authors: Nurish Amanah
Published: May 2024

This paper investigates the portrait of Hadrami community in the land of Osing in Banyuwangi, East Java. Banyuwangi is one of the legendary towns where the Majapahit kingdom’s heritage was well preserved. This town is associated with indigenous ethnic people known as Osing, who have their own traditions, language, customs, and culture. Madurese, Javanese, Sundanese, Chinese, Europeans, and Hadramis are among the other ethnic groups that inhabit this region. Its diversity of languages, ethnic groups, and religions made Banyuwangi a welcoming place for Hadramis for centuries. During the Dutch East Indies, Hadramis conducted extensive trade via the island’s South Sea; this area was a trading port in East Javat. Hadrami community have permanently lived in the land of Osing since the early 18th century, bringing their livelihood, inter-ethnic marriage, Islamic teachings, and Arab culture. Therefore, this research examines religious and cultural embodiments between native people and Hadrami community in the land of Osing. The findings of this research show that Hadrami community in the land of Osing adopted local language for Islamic da‘wah. Furthermore, the Hadrami community has had a cultural impact on fashion, food, music, and religious tourism, with umrah and hajj becoming increasingly popular among native people since the late nineteenth century.
A Generative AI-Based Virtual Physician Assistant
Authors: Rutledge Geoffrey W. , Sivura Alexander
Published: May 2024

We describe "Dr. A.I.", a virtual physician assistant that uses generative AI to conduct a pre-visit patient interview and to create a draft clinical note for the physician. We document the effectiveness of Dr. A.I. by measuring the concordance of the actual diagnosis made by the doctor with the generated differ-ential diagnosis (DDx) list. This application demonstrates the practical healthcare capabilities of a large language model to improve efficiency of doctor visits while also addressing safety concerns for the use of generative AI in the workflow of patient care.
Adaptive Federated Learning for Automatic Modulation Classification Under Class and Noise Imbalance
Authors: Sanchez Viloria Jose Angel , Stripelis Dimitris , Markopoulos Panos P. , Sklivanitis George , Pados Dimitris A.
Published: May 2024

The ability to rapidly understand and label the radio spectrum in an autonomous way is key for monitoring spectrum interference, spectrum utilization efficiency, protecting passive users, monitoring and enforcing compliance with regulations, detecting faulty radios, dynamic spectrum access, opportunistic mesh networking, and numerous NextG regulatory and defense applications. We consider the problem of automatic modulation classification (AMC) by a distributed network of wireless sensors that monitor the spectrum for signal transmissions of interest over a large deployment area. Each sensor receives signals under a specific channel condition depending on its location and trains an individual model of a deep neural network (DNN) accordingly to classify signals. To improve modulation classification accuracy, we consider federated learning (FL) where each individual sensor shares its trained model with a centralized controller, which, after aggregation, initializes its model for the next round of training. Without exchanging any spectrum data (such as in cooperative spectrum sensing), this process is repeated over time. A common DNN is built across the net- work while preserving the privacy associated with signals collected at different locations. Given their distributed nature, the statistics of the data across these sensors are likely to differ significantly. We propose the use of adaptive federated learning for AMC. Specifically, we use FEDADAM -an algorithm using Adam for server optimization – and ex- amine how it compares to the FEDAVG algorithm -one of the standard FL algorithms, which averages client parameters after some local iterations, in particular in challenging scenarios that include class imbalance and/or noise-level imbalance across the network. Our extensive numerical studies over 11 standard modulation classes corroborate the merit of adaptive FL, outperforming its standard alternatives in various challenging cases and for various network sizes.
Toward Application to General Conversation Detection of Dementia Tendency from Conversation Based on Linguistic and Time Features of Speech
Authors: Sogabe Hiroshi , Numao Masayuki
Published: May 2024

Currently, MRI examinations and neuropsychological tests by physicians and clinical psychologists are used to screen for dementia, but they are problematic because they overwhelm medical resources and are highly invasive to patients. If automatic detection of dementia from conversations becomes feasible, it will reduce the burden on medical institutions and realize a less invasive screening method. In this paper, we constructed a machine learning model to identify dementia by extracting linguistic features and time features from the elderly corpus with a control group. Random Forest (RF), Support Vector Machine (SVM), and Logistic Regression (LR) were used in the model. We compared the AUC of the single topic model and the general topic model in three cases: (I) All Features, (II) Gini Impurity, and (III) PCA + Gini Impurity. The AUC of the model constructed using RF in (III) for a single topic was 0.91, showing higher AUC than in the previous study. Furthermore, topic analysis showed that topics with high similarity in utterance content are effective in identifying MCI.
In the case of the general topic, the model with AUC of 0.8 showed a high identification performance for unknown topics by cross validation on a topic-by-topic basis, indicating that the general topic model developed in this study can be applied to general conversation.
Implications of Identity in AI: Creators, Creations, and Consequences
Authors: Tadimalla Sri Yash , Maher Mary Lou
Published: May 2024

The field of Artificial Intelligence (AI) is rapidly advancing, with significant potential to transform society. However, it faces a notable challenge: lack of diversity, a longstanding issue in STEM fields. In this context, this position paper examines the intersection of AI and identity as a pathway to understanding biases, inequalities, and ethical considerations in AI development and deployment. We present a multifaceted definition of AI identity, which encompasses its creators, applications, and their broader impacts. Understanding AI's identity involves analyzing the diverse individuals involved in AI's development, the technologies produced, and the social, ethical, and psychological implications. After exploring the AI identity ecosystem and its societal dynamics, We propose a framework that highlights the need for diversity in AI across three dimensions: Creators, Creations, and Consequences through the lens of identity. This paper presents a research framework for examining the implications and changes needed to foster a more inclusive and responsible AI ecosystem through the lens of identity.
Advances in Chronic Wound Management: From Conventional Treatment to Novel Therapies and Biological Dressings
Authors: Andleeb Anisa , Khan Hamza , Andleeb Aneeta , Khan Maria , Tariq Muhammad
Published: May 2024

Chronic wounds can be classified as diabetic foot ulcers, pressure ulcers, or venous leg ulcers. Chronic wound management has become a threat to clinicians and constitutes a major healthcare burden. The healing process of chronic wounds requires many factors to work in concert to achieve optimal healing. Various treatment options, ranging from hypoxia to infection, have evolved considerably to address the challenges associated with chronic wound healing. The conventional and accelerating treatments for chronic wounds still represent an unmet medical need due to the complex pathophysiology of the chronic wound microenvironment. In clinical settings, traditional chronic wound care practices rely on nonspecific topical treatment, which can reduce pain and alleviate disease progression with varying levels of success but fail to completely cure the wounds. Conventional wound dressings, such as hydrocolloids, gauze, foams, and films, have also shown limited success for the treatment of chronic wounds and only act as a physical barrier and absorb wound exudates. Emerging advances in treatment approaches, including novel therapies (stem cells, microRNAs, and nanocarrier-based delivery systems) and multifunctional biological dressings, have been reported for chronic wound repair. This review summarizes the challenges offered by chronic wounds and discusses recent advancements in chronic wound treatment.
Matür daimi dişlerde vital pulpa tedavilerine güncel bir bakış-derleme makalesi
Authors: Sarı Merve , Tufenkci Pelin
Published: May 2024

Çürükle ekspoze matür daimi dişlerin tedavisinde geleneksel kök kanal tedavisine alternatif olarak vital pulpa tedavilerinin uygulanması tartışmalı bir konudur. Diş pulpasının bir kısmının veya tamamının sağlığını korumayı amaçlayan vital pulpa tedavileri minimal müdahale prensibine dayanmaktadır ve indirekt kuafaj, direkt kuafaj, parsiyel pulpotomi ve total pulpotomi prosedürlerini içermektedir. Vital pulpa tedavileri kök kanal tedavisi ile karşılaştırıldığında daha hızlı ve teknik olarak daha az karmaşık olmasıyla birlikte kanal tedavisi sonrası görülebilen renk değişikliği, kök kırığı veya rezidüel periapikal inflamasyon gibi istenmeyen etkiler açısından daha avantajlıdır. Vital pulpa tedavilerinin geleneksel endikasyonları, geri dönüşümlü pulpitis teşhisi konmuş, kök oluşumu tamamlanmış veya henüz tamamlanmamış dişlerin tedavisi ile sınırlı kalmıştır. Bununla birlikte, rejeneratif endodontinin ortaya çıkışı ve invaziv müdahaleyi azaltmayı amaçlayan biyolojik temelli tedavilerin teşviki, çürükle ekspoze pulpanın histopatolojisinin ve iltihaplı pulpanın iyileşme potansiyelinin daha iyi anlaşılması, hidrofilik kalsiyum silikat simanlar gibi yüksek sızdırmazlık yeteneği ve biyoaktif poyansiyeli olan yeni materyallerin geliştirilmesi, vital pulpa tedavilerinin geri dönüşümsüz pulpitise işaret eden belirti ve semptomları olan dişlerde de bir tedavi protokolü olarak benimsenmesini teşvik etmiştir. Bununla birlikte mevcut kanıtların büyük bir bölümü nispeten düşük hasta sayısı içeren çalışmalarla desteklenmektedir. Sonuç olarak daha temsili pulpa teşhis araçlarının geliştirilmesi ve kanıta dayalı yönetim stratejilerinin oluşturabilmesi için bu konuyla ilgili iyi tasarlanmış ileriye dönük araştırmalara olan ihtiyaç devam etmektedir.
La paca biodigestora. Construcción social de la ciencia
Authors: Ossa Carrasquilla Laura Catalina , Medina Rúa Mónica Patricia , Gallego Luján Mayra Liseth
Published: May 2024

Este libro es un producto de apropiación social del conocimiento que da cuenta del proceso de tratamiento de los residuos orgánicos por medio de la paca biodigestora. En sus páginas el lector encontrará algunas estrategias de aprovechamiento de tales residuos con la aplicación del método anunciado: la construcción de un jardín para mariposas, el cultivo de hongos comestibles, el desarrollo de huertos ecológicos, el paisajismo, la cobertura vegetal
Mecánica celeste. Teoría, algoritmos y problemas
Authors: Zuluaga Callejas Jorge Iván
Published: May 2024

Este libro presenta una visión panorámica de la mecánica celeste —la ciencia del movimiento de los planetas y los vehículos espaciales— y en general de la mecánica analítica o mecánica clásica, que se desarrolló de forma paralela a la primera, inspirada, en muchos casos, en problemas astronómicos. El texto se dirige a quienes, por su formación o trabajo, están interesados en la aplicación de la mecánica celeste en astronomía o en ciencias espaciales. Su extensión, énfasis y nivel de profundidad lo hacen adecuado para estudiantes de pregrado de cualquier programa científico o técnico, especialmente de astronomía, física o ingeniería aeroespacial. Su enfoque computacional permite que además pueda ser usado como material de referencia en temas de programación aplicada para profesionales de estas y otras disciplinas
Modern issues of oncofertility and oncoreproduction
Authors: Petrov I. A. , Churkin E. O. , Arkhipova Ya. I. , Chernyshova A. L. , Chernyakov A. A. , Sevostyanova N. V.
Published: May 2024

The problem of the occurrence of malignant neoplasms in women of reproductive age has not only medical, but also extremely important social significance, as it affects the demographic potential of the country as a whole.The article presents an analysis of the current state of the problem of fertility and preservation of reproductive function in cancer patients. Currently, there are a sufficient number of methods of assisted reproductive technologies aimed at preserving fertility in women with cancer. Among them are the following: cryopreservation of embryos and oocytes, ovarian tissue, in vitro maturation of eggs, obtaining oocytes obtained by removing the ovaries with their subsequent maturation. In addition, auxiliary methods are also distinguished, the main purpose of which is ovarian protection: the use of gonadotropin-releasing hormone agonists, ovarian transposition, gonadal screening. Each method has its advantages and disadvantages. It should be noted that the very fact of the presence of oncological pathology makes its own adjustments to the use of each specific technique. It has been shown that in vitro maturation technology is the most optimal for the preservation and realization of reproductive function in cancer patients. One of its few disadvantages is the high cost and complexity of laboratory control and cultivation of oocytes, which undoubtedly requires highly qualified specialists and relevant experience.
Fluorescent signal lymph node mapping using indocyanine green in early breast cancer patients (Botkin Hospital experience)
Authors: Titov K. S. , Lebedinskiy I. N. , Kuts I. N. , Dzhamilov Sh. R. , Sukhotko A. S. , Lorie Z. V. , Bagateliya Z. A. , Lebedev S. S. , Grekov D. N.
Published: May 2024

Modern diagnostic methods with more accurate staging of the tumor process and effective high-tech treatment of breast cancer are very relevant, since this disease ranks first in the structure of cancer morbidity and mortality among women. Mapping of the signal lymph node is an alternative to axillary lymphatic dissection in patients with clinically intact regional lymph nodes (cN0). This allows patients to avoid such formidable, often and disabling complications of lymphatic dissection as prolonged postoperative lymphorrhea and lymphatic swelling of the upper extremity (lymphostasis). Radioisotope is the standard method of performing lymph node mapping, but recent years there have been more and more scientific studies and publications on the effectiveness of the non-toxic and non-radioisotope method in oncosurgery – fluorescent lymphography with indocyanine green.This article analyzes the experience and results of performing a mapping signal lymph node by a fluorescent method with indocyanine green at an early staged breast cancer in the Botkin Hospital, Moscow.
Effectiveness of cyclin-dependent kinase 4 and 6 inhibitors for the treatment of hormonesensitive HER2-negative metastatic breast cancer in first-line therapy: A systematic literature review
Authors: Avxentyev N. A. , Andreyashkina I. I. , Artamonova E. V. , Bolotina L. V. , Kovalenko E. I. , Sisigina N. N.
Published: May 2024

At present, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors such as palbociclib, ribociclib, and abemaciclib are widely used for the first-line treatment of locally advanced or metastatic breast cancer. However, direct comparisons of these treatment options in randomized studies have not been conducted.

Aim of the work is to gather and analyze published data on the comparative effectiveness of CDK4/6 inhibitors in combination with aromatase inhibitors in postmenopausal patients with HR+/HER2– locally advanced or metastatic breast cancer. A systematic review of publications presenting results from original studies on the impact of CDK4/6 inhibitor therapy in combination with aromatase inhibitors on the survival of patients was performed. Nineteen studies with original data on progression-free survival and overall survival were identified. None of the studies found significant differences between different CDK4/6 inhibitors and aromatase inhibitors in terms of progression-free survival. A statistically significant superiority of ribociclib over palbociclib in terms of overall survival was observed in a single matching-adjusted indirect comparison, while seven other studies of various types (real-world data studies, matching-adjusted indirect comparisons, and meta-analyses) did not find significant differences between the investigated drugs in terms of overall survival.

Currently, there is no compelling evidence of the superiority of one CDK4/6 inhibitor over others. The decision on the preference for a specific drug within the class can only be made after conducting direct randomized comparison trials, or accumulating sufficient real-world data on the use of palbociclib, ribociclib, and abemaciclib.
Algorithm for joint estimation and compensation of signals time and frequency synchronization errors with estimation accuracy control
Authors:   Tomsk State University of Control Systems and Radioelectronics, Mukhamadiev Semen M. , Rogozhnikov Eugeniy V. ,   Tomsk State University of Control Systems and Radioelectronics, Rehab Hashem K.H.A.A. ,   Tomsk State University of Control Systems and Radioelectronics, Dinochenko Kirill V. ,   Tomsk State University of Control Systems and Radioelectronics, Kryukov Yakov V. ,   Tomsk State University of Control Systems and Radioelectronics, Kalashnikova Natalya G. ,   Tomsk State University of Control Systems and Radioelectronics
Published: May 2024

An analysis of the influence of synchronization errors on signal processing is presented, a review of existing approaches for estimating and compensating for time and frequency synchronization errors is given, a new approach is proposed that allows joint evaluation of time and frequency offsets, providing a more accurate estimate compared to existing analogues and, moreover, regulating accuracy of fractional error estimation of both time and frequency synchronization.
Terahertz plasmon modes excitation in a graphene square microcavity
Authors:   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Saratov Branch, Polischuk Olga V. , Fateev Denis V. ,   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Saratov Branch, Popov Viacheslav V. ,   Kotel'nikov Institute of Radioengineering and Electronics of RAS, Saratov Branch
Published: May 2024

We consider a graphene square located in the interface between two half-spaces with different dielectric constants. Using a self-consistent electromagnetic approach based on the integral equation method, we solve the problem of a linearly polarized terahertz electromagnetic wave scattering by the graphene square. The spectra of extinction, absorption, and scattering cross sections reveal the various plasmon modes excitation in graphene square. The properties of the plasmon modes different types are discussed.
Electrophysical and temperature characteristics of Ag2S quantum dots thin layers
Authors:   Vernadsky Crimean Federal University, Mazinov Alim S. , Tyutyunik Andrey S. ,   Vernadsky Crimean Federal University, Gurchenko Vladimir S. ,   Vernadsky Crimean Federal University
Published: May 2024

This paper presents a study of the electrical properties of colloidal silver sulfide quantum dots thin films (Ag2S/SiO2 QDs) and silver sulfide quantum dots decorated with Au plasmon nanoparticles (Ag2S/SiO2/Au QDs). A study of the conductivity temperature dependences was carried out in the temperature range from 300 to 360 K. The activation energy values were obtained from linear approximations of the current-voltage characteristics in Arrhenius coordinates. It has been shown that decorating Ag2S/SiO2 QDs with Au plasmon nanoparticles leads to an increase in the band gap from 0.29 to 0.89 eV. In this work, the ideality factor is calculated and the main conductivity mechanisms of the presented thin-film structures are determined. It has been shown that decorating Ag2S/SiO2 QDs with Au plasmon nanoparticles leads to a change in the conductivity type. According to the Mott-Gurney model, the charge carriers mobility is calculated.
Graphical GLX-applications functioning ensuring on industrial equipment using the EGL API
Authors:   Scientific Research Institute of System Analysis of the RAS, Tatarchuk Ivan A. , Mamrosenko Kirill A. ,   Scientific Research Institute of System Analysis of the RAS, Giatsintov Alexander M. ,   Scientific Research Institute of System Analysis of the RAS
Published: May 2024

This paper discusses the operation of engineering software on systems with graphics adapter drivers that provide limited to no support for certain graphics subsystems of Linux OS. The paper demonstrates that software with GLX API-based visualization subsystem needs modification to be ported to the embedded systems using graphics accelerators with drivers that support only the EGL API. The purpose of the study is to develop approaches for enabling the operation of software on industrial equipment and utilizing the GLX API via the EGL API of the Linux-based graphics subsystem. The paper discussed the method for translating GLX API calls to the EGL API and its applicability. A new algorithm has been developed for organizing interaction between user applications and the Linux OS graphics subsystem, which allows running applications with the GLX API in the absence of DRI support by the graphics accelerator driver. The correctness of the algorithm’s operation has been tested and compared with the results of the tests of open drivers with DRI2 support. The findings will make it possible to reduce the resources needed to support individual graphics driver subsystems and make a smooth transition to using the EGL API in the embedded systems.
Current distribution in comb structures of bipolar and heterobipolar microwave transistors taking into account the metallization tracks resistance
Authors:   Институт радиотехники и электроники им. В.А. Котельникова РАН, Ульяновский филиал, Сергеев Вячеслав А. , Ходаков Александр М. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН, Ульяновский филиал, Фролов Илья В. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН, Ульяновский филиал, Казанков Александр А. ,   Ульяновский государственный технический университет
Published: May 2024

Представлен краткий анализ причин неоднородного и неустойчивого распределения тока между элементарными транзисторами в гребенчатых структурах (ГС) биполярных (БТ) и гетеробиполярных (ГБТ) СВЧ транзисторов. Получено выражение для тока, втекающего в элементарный транзистор ГС, с учетом сопротивления эмиттерной дорожки металлизации. Приведена оценка влияния технологического разброса сопротивлений эмиттерных дорожек металлизации на неравномерность распределения полного тока транзистора между элементарными транзисторами. Показано, что сопротивление эмиттерных дорожек металлизации играет стабилизирующую роль и приводит к повышению тепловой устойчивости токораспределения в ГС, при этом наименее устойчивым к тепловому пробою будет элементарный транзистор ГС с наименьшим сопротивлением эмиттерной дорожки и наибольшим тепловым сопротивлением. Предложены рекомендации по выравниванию и повышению устойчивости токораспределения в ГС БТ и ГБТ.
Terahertz plasmon modes excitation in a graphene square microcavity
Authors:   Институт радиотехники и электроники им. В.А. Котельникова РАН, Саратовский филиал, Полищук Ольга В. , Фатеев Денис В. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН, Саратовский филиал, Попов Вячеслав В. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН, Саратовский филиал
Published: May 2024

Рассматривается графеновый квадрат, расположенный на границе раздела между двумя полупространствами с разными диэлектрическими постоянными. Проблема исследована в трехмерной постановке задачи с использованием самосогласованного электродинамического подхода, основанного на методе интегрального уравнения. Решена задача о рассеянии линейно поляризованной терагерцовой волны на графеновом квадрате. Рассчитанные спектры сечений экстинкции, поглощения и рассеяния демонстрируют возбуждение серии плазмонных мод в графеновом квадрате. Обсуждаются свойства различных типов плазмонных мод.
Noise signals resolution in the random inhomogeneities presence of oceanic environment
Authors:   Институт общей физики им. А.М. Прохорова РАН, Кузькин Венедикт М. , Переселков Сергей А. ,   Воронежский государственный университет, Грачев Владимир И. ,   Институт радиотехники и электроники им. В.А. Котельникова РАН, Ткаченко Сергей А. ,   Воронежский государственный университет, Рыбянец Павел В. ,   Воронежский государственный университет
Published: May 2024

Обсуждено формирование голограммы шумовых сигналов в случайно-неоднородной океанической среде. Показано, что голограмма сигналов нескольких источников представляется преимущественно сумой голограмм сигналов, формирующихся невозмущенными и возмущенными полями. Описан метод очищения голограммы от возмущенных полей. Предложены критерии разрешения сигналов. Приведены результаты численного моделирования по разрешению двух сигналов и оценке параметров источников на фоне интенсивных внутренних волн, вызывающих горизонтальную рефракцию мод звукового поля.
Graphical GLX-applications functioning ensuring on industrial equipment using the EGL API
Authors:   Научно-исследовательский институт системных исследований РАН, Татарчук Иван А. , Мамросенко Кирилл А. ,   Научно-исследовательский институт системных исследований РАН, Гиацинтов Александр М. ,   Научно-исследовательский институт системных исследований РАН
Published: May 2024

В работе рассматриваются вопросы функционирования программного обеспечения для решения инженерных задач в условиях ограниченной поддержки драйверами графического адаптера отдельных подсистем графического стека OS Linux. Показано, что инженерное и управляющее промышленным оборудованием ПО, подсистема визуализации которого использует API GLX будет требовать доработки для переноса на встраиваемые системы, использующие графические ускорители с драйверами поддерживающими только API EGL. Целью исследования является разработка подходов для обеспечения функционирования программного обеспечения, применяющегося на промышленном оборудовании и использующего API GLX, через API EGL в графической подсистеме ОС Linux. Рассмотрен метод трансляции вызовов GLX API в EGL API, определена его применимость. Разработан новый алгоритм организации взаимодействия между пользовательскими программами и графической подсистемой ОС Linux, позволяющим запускать приложения, использующие GLX API в условиях отсутствия поддержки DRI драйвером графического ускорителя. Проведено тестирование корректности работы алгоритма и проведено сравнение с результатами тестирования открытых драйверов с поддержкой DRI2. Полученные результаты позволят сократить затраты ресурсов на поддержку отдельных подсистем графических драйверов.
Dynamic Spectrum Sharing: A Quick fix to 5G deployment
Authors:   Национальный технологический институт Курукшетра, Шарма Нидхи , Ахлават Приянка ,   Национальный технологический институт Курукшетра, Аггарвал Раджеш К. ,   Национальный технологический институт Курукшетра
Published: May 2024

Как статическое распределение частотного спектра, развернутое в 4G-LTE, так и динамически настраиваемые каналы физического уровня 5G NR не удовлетворяют требованиям текущего экспоненциального роста числа пользователей беспроводной связи. Поскольку 5G NR будет работать лучше в сценариях прямой видимости (LOS), в то время как 4G-LTE обеспечивает замечательную производительность в сценариях отсутствия прямой видимости (NLOS). Динамическое совместное использование спектра (DSS) позволяет операторам одновременно запускать LTE и 5G NR в одном диапазоне. Эта статья иллюстрирует взаимосвязь и рабочую теорию динамического разделения спектра, чтобы понять, как последний стандарт 5G приведет к существенному улучшению средней пропускной способности пользователя и повышению эффективности сети. Это попытка предложить общую структуру для первоначального развертывания сети 5G.
Primary prevention of venous thromboembolism with low molecular weight heparins in surgical patients – 2024: Council of Experts resolution
Authors: Petrikov А. S. , Vavilova Т. V. , Vardanyan А. V. , Zamyatin М. N. , Zolotukhin I. А. , Lobastov К. V. , Roitman Е. V. , Seliverstov Е. I. , Stoyko Yu. М. , Suchkov I. А.
Published: May 2024

On March 15, 2024, in Moscow, the Russian Phlebological Association and the National Association of Specialists in Thrombosis, Clinical Hemostasiology and Hemorheology organized a meeting of the Council of Experts during the Russian Forum on Thrombosis and Hemostasis on the acute issues of venous thromboembolism (VTE) primary prevention using low molecular weight heparins (LMWH) in surgical patients with different body weight. The participants reviewed the relevance and prevalence of this problem in surgical practice, discussed risk factors and the frequency of VTE development, including bleeding in the postoperative period, and the Caprini risk score for complications. The discussion also focused on standard and personalized LMWH doses for primary prophylaxis of VTE in the perioperative period in surgical patients, depending on body weight, and the role of laboratory tests, including assessment of LMWH anti-Xa activity for monitoring the efficacy and safety of VTE primary prevention in clinical practice.
Prediction of hypertensive disorders in pregnant women in the «gray» risk zone following combined first-trimester screening
Authors: Mostova N. V. , Kovalev V. V. , Kudryavtseva E. V.
Published: May 2024

Introduction. In obstetrics, hypertensive disorders of pregnancy (HDP) including preeclampsia (РЕ) are one of the primary causes resulting in critical cases and maternal mortality. HDP prediction is a milestone that allows preventing complications as well as reducing the number of most common relevant complications of pregnancy. Existing algorithms that predict PE risk distribute the risks in such a way that a considerable number of patients fall into the category of false negative results, and, consequently, receive no timely prevention and proper follow-up. In particular, this cohort usually consists of patients with borderline high risks, who may be designated as a medium risk group or located in a “gray” zone.

   Aim: to develop a prognostic model for risk stratification in female patients with borderline to high developing PE risk based on combined first-trimester screening.

   Materials and Methods. A prospective comparative study included 1089 female patients who underwent a combined screening at 11–14 weeks of gestation. Group 1 consisted of female patients at high РЕ risk (1:100 and greater), while female patients at moderate risk (1:101–1:250) and low risk (below 1:250) were included into Group 2 and Group 3, respectively. All pregnant women underwent examination including assessed anamnestic, general clinical and laboratory data, mean blood pressure (BP), uterine artery pulsatility index, serum level of human chorionic gonadotropin beta-subunits (β-hCG), placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A).

   Results. An impact of various factors on risk of developing hypertensive disorders in pregnancy was assessed by binary logistic regression by identifying most significant among them and generating a statistical prediction model – the prognostic index of hypertensive disorders in pregnancy. The latter included: obstetric history, body mass index, PlGF, mean ВР, and alanine aminotransferase level. The sensitivity and specificity comprised 91.2 and 53.6 %, respectively, and the method effectivenesswas 81.8 %.

   Conclusion. The method proposed for HDP prediction is a second-line approach that may be used in clinical practice to stratify patients with borderline high risk of developing PE.
O Processo Imaginário de um Aluno com Transtorno do Espectro do Autismo nas Aulas de Educação Física
Authors: Barbuio Rodrigo
Published: May 2024

ResumoEste estudo investiga o processo educativo de um aluno com Transtorno do Espectro do Autismo, com foco para suas aulas de Educação Física. Tem como objetivo compreender e interpretar o processo imaginário de um aluno com Transtorno do Espectro do Autismo durante suas aulas. A pesquisa se fundamenta de forma teórica e metodologicamente na perspectiva histórico-cultural do desenvolvimento humano, em especial, nas elaborações de Lev Semionovitch Vigotski sobre a constituição social do desenvolvimento humano e suas proposições sobre as condições de possibilidades de desenvolvimento de pessoas com deficiência. Ancora-se no método histórico-dialético e nos estudos biográficos ao trazer a narrativa como instância simbólica da linguagem e como instrumento de elaboração para a produção do trabalho empírico. A construção dos dados foi realizada em uma escola pública municipal de uma cidade de médio porte do interior do estado de São Paulo, durante o ano letivo de 2019, sendo esses dados registrados por meio de entrevistas narrativas. Os resultados apontam que o uso de atividades de imaginação e criatividade em alunos com Transtorno do Espectro do Autismo apresentam processos significativos para esses alunos. Ademais, os achados apontam que as decisões sobre as propostas pedagógicas não podem ser tomadas a priori, mas sim construídas na escuta desses alunos.
Palavras-chave: Educação Especial. Educação Inclusiva. Autismo. Educação Física.
Abstract
This study investigates the educational process of a student with Autism Spectrum Disorder, focusing on his or her Physical Education classes. It aims to understand and interpret the imaginary process of a student with Autism Spectrum Disorder during his or her classes. The research is theoretically and methodologically based on the cultural-historical perspective of human development, in particular Lev Semionovich Vygotsky's elaborations on the social constitution of human development and his propositions on the conditions of development possibilities for people with disabilities. It is anchored in the historical-dialectical method and in biographical studies, as it uses narrative as a symbolic instance of language and as an instrument of elaboration for the production of the empirical work. The data were collected in a municipal public school in a medium-sized city in the interior of the state of São Paulo, during the 2019 school year, and recorded through narrative interviews. The results show that the use of imagination and creativity activities in students with Autism Spectrum Disorder presents significant processes for these students. In addition, the findings indicate that decisions about pedagogical proposals cannot be taken a priori, but rather built on listening to these students.
Keywords: Special Education. Inclusive Education. Autism . Physical Education.
Entrepreneurial Public University: Perspective of Legal Regulations
Authors: Pisarski Ludwik
Published: May 2024

The aim of the study is to identify a collection of legal regulations relating to the implementation of three missions of public universities, which are collectively included in the concept of an entrepreneurial university. The fundamental question to be answered is whether the legal environment in Poland is favorable to the implementation of the mission of an entrepreneurial university by public universities. The conducted research provided arguments which led to the conclusion that currently universities can pursue three missions that are consistent with the ones constituted by the contemporary model of an entrepreneurial university. This also makes it possible to state that there are no legal grounds preventing the implementation of the three missions constituting the model of an entrepreneurial public university, i.e. education, conducting scientific research and commercializing research results by, among others, providing research services that are transferred to the society and the economy.