bluuebunny/crossref_metadata_2025 huggingface dataset:
Who captures the state? Evidence from irregular awards in a public innovation grant program
Authors: Wang Yanbo , Siegel Jordan , Li Jizhen
Published: July 2024

Research summary

This study utilizes the administrative data of an innovation grant program in a major emerging economy to study which firms are best positioned to capture the state and access resources beyond what their rule‐complying merits command. We trace the grant allocation process and directly observe occurrences of rule‐violating funding. We show that firms vary in capability to secure irregular awards, depending on factors such as geographic proximity and the social and bureaucratic setting within which entrepreneurs and officials interact. Furthermore, by comparing the actual allocation of irregular awards with the counterfactual scenario in which recipients were evaluated solely based on grant rules, we conclude that crony capitalism, rather than bureaucratic heroism, is the primary driver of irregular awards.

Managerial summary

Governments often use innovation grant programs to promote firm innovation, but these programs sometimes fail to achieve their objectives due to grant officials violating policy rules to provide resources to undeserving firms. We study a public funding program in a major emerging economy to analyze the bureaucratic structure and the social dynamics within which entrepreneurs and bureaucrats interact to identify the sources of state‐resource misallocation. We find that geographic distance, intragovernmental checks and balances, and the lack of direct social intermediary connecting entrepreneurs with bureaucrats help reduce the likelihood of collusion for state‐resource misallocation. Our results generate insights to help guide the (re)design of public funding programs, particularly in countries with low levels of transparency and public accountability.
Making business model decisions like scientists: Strategic commitment, uncertainty, and economic performance
Authors: Novelli Elena , Spina Chiara
Published: July 2024

Research Summary

This study abductively investigates how a firm's degree of business model development—the extent to which strategic choices are crystallized—moderates the impact of a scientific approach to decision‐making on performance. We present findings from a field experiment involving 261 entrepreneurs, where treated entrepreneurs learn to apply a scientific approach, while control counterparts receive comparable content without this approach. Results show that the effect of scientific decision making varies with business model development. Treated entrepreneurs with higher degrees of business model development elaborated their theories of value focusing on lower‐level choices, achieving superior economic performance compared to controls. Conversely, treated entrepreneurs with lower levels of business model development reevaluated fundamental aspects, resulting in increased epistemic uncertainty and less favorable short‐term economic outcomes compared to controls.

Managerial Abstract

Using a field experiment with 261 entrepreneurs, we explored how the degree of business strategy definition influences the benefits of adopting a scientific approach to decision‐making. In the experiment, half of the entrepreneurs were taught to use a scientific approach for making decisions (the treated group), while the others received similar training without the scientific approach (the control group). Results show that treated entrepreneurs with already defined strategies benefited more, experiencing improved performance even in the short term. Conversely, treated entrepreneurs with strategies still under definition experienced more uncertainty and lower short‐term economic performance, as the scientific approach prompted them to reassess and adjust their core strategic decisions.
Supercrystal Engineering of Nanoarrows Enabled by Tailored Concavity
Authors: Chen Cheng , Wang Qian , Wang Peijian , Dai Mengqi , Jiang Xin , Zhou Jihan , Qi Limin
Published: July 2024

Self‐assembly of nanoparticles into supercrystals represents a powerful approach to create unique and complex superstructures with fascinating properties and novel functions, but the complexity in spatial configuration, and the tunability in lattice structure are still quite limited compared to the crystals formed by atoms and molecules. Herein, shallowly concave gold nanoarrows with a unique concave‐convex geometry are synthesized and employed as novel building blocks for shape‐directed self‐assembly of a wealth of complex 3D supercrystals with unprecedented configurations. The obtained diverse superstructures including six Interlocking‐type supercrystals and three Packing‐type supercrystals exhibit four types of Bravais lattices (i.e., tP, oI, tI, and oF) and six types of crystallographic space groups (i.e., Pmmm, I222, Pnnm, Ibam, I4/mmm, and Fmmm), which have not been documented in the mesoscale self‐assembled systems. It has been revealed that the relative yield of different supercrystal structures is mainly determined by the packing density and deformability of the supercrystals, which are closely related to the tailored concavity of the nanoparticles and is affected by the particle concentration, thus allowing for programmable self‐assembly into specific supercrystals through particle shape modulation. The concavity‐enabled supercrystal engineering may open a new avenue toward unconventional nanoparticle superstructures with expanded complexity, tunability, and functionality.
In Situ Growth of Hierarchical Silver Sub‐Nanosheets on Zinc Nanosheets‐Based Hollow Fiber Gas‐Diffusion Electrodes for Electrochemical CO2 Reduction to CO
Authors: Chen Guoliang , Ge Lei , Kuang Yizhu , Rabiee Hesamoddin , Ma Beibei , Dorosti Fatereh , Nanjundan Ashok Kumar , Zhu Zhonghua , Wang Hao
Published: July 2024

Electrochemical reduction of CO2 (CO2RR) is an effective strategy to mitigate carbon emission effects and store renewable electricity in value‐added feedstocks, but it still suffers low production rate and current density. A nanostructured catalyst offers opportunities to enhance CO2RR activity by contributing numerous active sites and promoting charge transfer. Herein, a Cu hollow fiber gas diffusion electrode (HFGDE) with silver sub‐nanosheets on a zinc nanosheet structure to produce CO is reported. Compared to the HFGDE only possessed zinc nanosheet structure, the as‐prepared HFGDE with hierarchical sub‐nano AgZn bimetal nanosheets exhibits a twice‐partial current density of CO and a CO production rate at the applied potential −1.3 V (versus reversible hydrogen electrode). The unique Ag sub‐nanosheets interconnected Zn nanosheets provide multiple charge transfer channels, and the synergistic effect between Ag and Zn improves the adsorption binding energy of COOH* intermediate, resulting in a lower charge transfer resistance and fast CO2RR kinetics to produce CO. This research demonstrates the high potential of nanoengineering electrocatalysts for HFGDE to achieve highly efficient CO2 reduction.
Axial compressive performance of RC columns strengthened with prestressed CFRP fabric and UHPC jacket with spiral stirrups
Authors: Wang Qiang , Liang Xu‐hua , Liu Xin , Guo Shi‐ping , Lu Chun‐ling
Published: July 2024

To address the issue of easy shearing damage of Carbon Fiber Reinforced Polymer (CFRP) in enhancing the axial compressive performance of CFRP and Ultra‐High‐Performance Concrete (UHPC) strengthened concrete columns, two methods, prestressed CFRP and UHPC with spiral stirrups, were employed for composite strengthening of reinforced concrete (RC) columns. A total of one unstrengthened column and eight strengthened columns were designed and fabricated to validate the effectiveness of the proposed methods. The axial compressive performance and bearing capacity of each specimen were analyzed by considering parameters such as single or composite strengthening method, presence of spiral stirrups in UHPC, and application of pre‐stressed CFRP. The results show that, compared with any single strengthened specimen, the ultimate bearing capacity of the composite strengthened specimen is greater than the sum of the corresponding single strengthened specimens, and the bearing capacity of the prestressed CFRP with spiral stirrup UHPC composite strengthened specimen is the most significant, reaching 235.63%. By incorporating spiral stirrups in the UHPC jacket, the phenomenon of uneven fragmentation during the failure of the strengthened column is improved. This helps prevent premature shearing damage of CFRP and enhances the fracture strain and effective utilization of CFRP. Additionally, prestressed CFRP effectively restrains the lateral deformation and crack development of the core concrete in the UHPC jacket, fully utilizing the high compressive strength of UHPC. This further enhances the ultimate bearing capacity and ductility of the specimens. Based on the experimental phenomena and strain of each material, the failure mechanism of prestressed CFRP‐spiral reinforced UHPC composite‐strengthened columns is proposed. Finally, a unified bearing capacity calculation formula for single and composite strengthened columns is established, based on the theory of confined concrete strength and the assumption of strength increment superposition. The formula is validated with experimental results from relevant literature, showing small errors in the calculated results and indicating good applicability of the formula.
Letter to the Editor re. 'Enhancing diagnostic value in urethral imaging: the case for urologist‐performed urethrograms'
Authors: Shkoukani Zakaria W , Pina Ines M , Omar Ahmad M , Floyd Michael S
Published: July 2024

A letter about the article on urologist‐led urethrography by Harrison et al. that appeared in the March/April 2024 issue (Trends in Urology & Men's Health 2024;15(2):5‐10.)
Reducing the death toll from fentanyl overdose
Authors: Kirby Roger
Published: July 2024

In this editorial, Professor Roger Kirby, Editor‐in‐Chief of Trends in Urology and Men's Health, considers the increasing rate of drug overdose, a problem that disproportionately affects men.
Dislodgement and aspiration of a tooth during endotracheal intubation in a cat
Authors: Makepeace Charles Henry , Khenissi Latifa
Published: July 2024

A 25‐week‐old Oriental shorthair cat was anaesthetised to perform computed tomography and bronchoscopy. During endotracheal intubation, a deciduous premolar was contacted with the laryngoscope blade, dislodged, and subsequently aspirated into the trachea. The tooth was removed via bronchoscopy, and the cat was recovered in the intensive care unit due to the development of laryngeal oedema. The risk factors for tooth dislodgement in the cat and proposed improvements in the immediate period after dislodgement are discussed in this report.
Forensic intelligence: Expanding the potential of forensic document examination
Authors: Devlin Ciara , Morelato Marie , Baechler Simon
Published: July 2024

Forensic document examination is characterized by its longevity, diversity, and evolution over time. Predominantly, published research within this field has focused on handwriting examination, the articulation of forensic conclusions, and the development of technical instrumental advancements, focusing on the use of document examination in the resolution of casework. This is a persistent and common problem within forensic science that Kirk identified in 1963 and that other authors have reaffirmed more recently. Ultimately, this has resulted in the potential of forensic intelligence, remaining relatively underexplored in the field of document examination. Forensic intelligence is a different way to view and analyze traces, shifting the focus from the traditional identification of source and activity, to instead identifying trends in criminal activity to assist in the reduction, prevention, and proactive disruption of crime. Despite a distinct disparity between these strands of research, there has been a persevering evolution toward the implementation of a systematic forensic intelligence method for the examination of fraudulent identity documents. Since its initial inception into the research community, this method has expanded and been implemented across Europe, and Canada, with tests also being conducted in Australia. These first tangible steps toward a forensic intelligence capacity within document examination have also inspired new work using forensic intelligence and systematic comparisons within the field of handwriting examination, as well as the recognition of the transversal potential of this method, with it being applied to both physical and digital documents. In this review, the fields of document examination and forensic intelligence will first be introduced, along with a subsequent examination of the research that has led to the creation of a forensic intelligence model within the field of document examination. It should be noted that this review has largely been limited to a review of research that has been published in English and French due to the language of the authors.

This article is categorized under:

Crime Scene Investigation > From Traces to Intelligence and Evidence

Forensic Chemistry and Trace Evidence > Emerging Technologies and Methods

Crime Scene Investigation > Epistemology and Method
Update of the Atmospheric Attraction Computation Service (Atmacs) for High-Precision Terrestrial Gravity Observations
Authors: Antokoletz Ezequiel D. , Wziontek Hartmut , Klügel Thomas , Balidakis Kyriakos , Dobslaw Henryk
Published: July 2024

The Atmospheric attraction computation service (Atmacs) of BKG provides atmospheric corrections for terrestrial high-precision gravity measurements based on operational weather models of the German Weather Service (DWD). In Atmacs, Newtonian attraction and deformation contributions to atmospheric loading are computed separately. The attraction component benefits from the discrete 3D distribution of air masses around the station, while deformation effects are derived from surface atmospheric pressure changes assuming that the oceans respond to atmospheric forcing as an Inverse Barometer (IB). Several improvements in the modelling approach of Atmacs are presented. A revision of the IB hypothesis implementation revealed that the attraction component over oceans was overestimated. A modification of the IB implementation not only resolves this issue but further enhances the compatibility between the atmospheric modelling and ocean models. This allows to complement Atmacs with non-tidal ocean loading effects, here based on the Max-Plank-Institute for Meteorology Ocean Model (MPIOM). These updates allow for a consistent combination of atmospheric and ocean models and a more efficient reduction of the signal recorded by high-precision terrestrial gravimeters.
Unfolding Innovation Through the Digitalisation of Institutional Practices
Authors: Sadownik Alicja R. , Fleer Marilyn , Fragkiadaki Glykeria , Rai Prabhat , Ødegaard Elin Eriksen
Published: July 2024

This chapter introduces Part IV, which presents the understanding of a crisis that is relevant to the chapters in this section. As the chapters report on the dialectics of searching and re-searching for new methods of continuation of academic practices (lecturing and research), the understanding of a crisis embraces a continuous vibrating and pivoting between contradictory meanings, digital and physical spaces and innovations and their uninnovative consequences. Another important perspective on crises and the dialectics of ‘innovating out of it’ discussed in this chapter relates to the different effects of innovations on individuals with different positions in academia. While PhD students received institutional support in the form of access to supervisors’ data and their universities’ networks, allowing them to redefine and continue their research projects, the undergraduate students became invisible black screens, gradually dropping out of the educational programmes, regardless of the teacher educators’ sense of increasing competence for digital teaching and learning.
How do emotions respond to outcome values and influence choice?
Authors: Grimani Aikaterini , Yemiscigil Ayse , Wang Qing , Kirilov Georgi , Kudrna Laura , Vlaev Ivo
Published: July 2024

Emotions powerfully, predictably, and pervasively influence decision making. The risk-as-feelings hypothesis states that two kinds of emotions are important in decision-making, anticipatory emotions and anticipated emotions. We empirically investigated whether and how anticipatory and anticipated emotions may change as a function of outcome values and whether anticipatory or anticipated emotions may explain the influence of outcome values on risky choice. To study the effects of value on emotions and choice, we offered people hypothetical large amounts ($100, $200, $300, $400) and incentivized moderate amounts ($10, $20, $30, $40) as prospects in gambles over two consecutive studies. Using a representative sample from the US to ensure the generalizability of the findings, each participant in our two studies made choices in gain and loss domains. Overall, anticipatory and anticipated emotions responded very similarly to changes in value for the sure gains in both studies. The findings also indicated that both anticipatory and anticipated emotions explained the effects of the value on choice for the sure gain and sure losses, while both mediated the effect of framing on choice towards the sure and the gamble option. Although anticipatory emotions mediated a larger portion of the effect, anticipated emotions also show some mediation.
Melt compounding of spray-dried cellulose nanofibrils/polypropylene and their application in 3D printing
Authors: Hwang Sungjun , Han Yousoo , Gardner Douglas J.
Published: July 2024

Micro- and nano-scale cellulosic fillers exhibit excellent dispersion and distribution within a thermoplastic matrix during the process of melt compounding or injection molding. In this study, spray-dried cellulose nanofiber (SDCNF) powders were manufactured using a pilot-scale rotating disk atomizer spray dryer. Bleached Kraft pulp (BKP), unbleached Kraft pulp (UKP), and old corrugated cardboard pulp (OCC) fibrillated at a fines level of 90% were used as feedstock materials for spray-drying. BKP-, UKP-, and OCC- SDCNFs were compounded with polypropylene using a twin screw co-rotating extruder. Maleic anhydride grafted polypropylene (MAPP) was used as a coupling agent in the composite formulations. The tensile, flexural, and impact properties of SDCNF-filled PP composites increased at 10 wt% SDCNF loading. The presence of SDCNFs in the PP matrix resulted in faster crystallization and a 12% reduction in the degree of crystallinity of the neat PP. The coefficient of thermal expansion (CTE) of neat PP was reduced by up to 31% attributable to the presence of the SDCNFs. Application of the SDCNF-reinforced PP composites in 3D printing reduced the shrinkage rate of the printed neat PP by 39%, and the printability of the PP was significantly improved with the addition of the SDCNFs.
Phase transition in polymer hydrogels investigated by swelling, DSC, FTIR and NMR
Authors: Krakovský Ivan , Hanyková Lenka , Štastná Julie
Published: July 2024

The swelling and thermal behavior of single (SN) and double network (DN) hydrogels containing polyacrylamide (PAAm) and temperature sensitive poly(N, N-diethylacrylamide) (PNNDEAAm) were investigated by gravimetry and differential scanning calorimetry (DSC). Changes of the hydration of carbonyl groups and mobility of polymer network chains in the hydrogels with temperature were studied by Fourier-transformed infrared and proton nuclear magnetic resonance (1H NMR) spectroscopy. The enthalpy of dissociation of the hydrophobic interaction, minimum and maximum numbers of water molecules per monomer unit in PNNDEAAm SN hydrogel involved in the hydrophobic hydration were determined by DSC. The volume phase transition accompanied by expulsion/uptake of water and heat absorption/release in heating/cooling was exhibited by all DN hydrogels containing PNNDEAAm. In these hydrogels, above the phase transition temperature, the population of hydrated carbonyls is enriched with the free and single hydrated ones in the same way as in the aqueous solution of linear PNNDEAAm and mobility of the PNNDEAAm chains is strongly reduced. Presence of the PAAm network does not influence the phase transition temperature but strongly reduces the enthalpy of the phase transition, promotes higher degrees of hydration of carbonyls, and increases mobility of the PNNDEAAm chains in the mixed hydrogels above the phase transition temperature.
Isolation and characterisation of two epithelial-like cell lines from the gills of Chrysophrys auratus (Australasian snapper) and Oncorhynchus tshawytscha (Chinook salmon) and their use in aquatic toxicology
Authors: Böhmert Björn , Chong Gavril L. W. , Lo Kim , Algie Michael , Colbert Damon , Jordan Melissa D. , Stuart Gabriella , Wise Lyn M. , Lee Lucy E. J. , Bols Niels C. , Dowd Georgina C.
Published: July 2024

In vitro gill models are becoming increasingly important in aquatic toxicology, yet the fish gill invitrome is underrepresented, encompassing approximately 0.1% of extant species. Here, we describe the establishment and characterisation of two gill-derived, epithelial-like cell lines isolated from fish species of significant importance to New Zealand: Chrysophrys auratus (Australasian snapper) and Oncorhynchus tshawytscha (Chinook salmon). Designated CAgill1PFR (Chrysophrys auratus,gill 1, Plant & Food Research) and OTgill1PFR (Oncorhynchus tshawytscha,gill 1, Plant & Food Research), these cell lines have each been passaged greater than each 70 times over several years and are considered spontaneously immortalised. Both cell lines required serum for growth and exhibited differential responses to basal media formulations. CAgill1PFR was sensitive to low temperatures (4 °C) but replicated at high temperatures (30 °C), whereas OTgill1PFR was sensitive to high temperatures but remained viable at low temperatures, mirroring the natural environment of their host species. Immunostaining revealed expression of epithelial cell markers cytokeratin and E-cadherin, alongside positivity for the mesenchymal cell marker, vimentin. CAgill1PFR was more sensitive to the environmental toxin 3,4 dichloroaniline than OTgill1PFR through measurements of metabolic activity, membrane integrity, and lysosomal function. Furthermore, CAgill1PFR produced less CYP1A activity, indicative of ongoing biotransformation processes, in response to beta-naphthoflavone than OTgill1PFR. These cell lines expand the toolbox of resources and emphasise the need for species-specific aquatic toxicology research.
Ultrasound Urodynamics: A Review of Ultrasound Imaging Techniques for Enhanced Bladder Functional Diagnostics
Authors: McCormack Brendan , Hampton Hailey L. , Speich John E. , Radley Stephen C. , Burkett Linda S. , Klausner Adam P.
Published: July 2024

Purpose of Review

Invasive urodynamics are currently used to diagnose disorders of bladder function. However, due to patient discomfort as well as artifacts induced by catheters and non-physiologic filling, less invasive screening tools that can improve diagnostic information, such as ultrasound are required. The purpose of this review is to assess different modalities of ultrasound as applied to functional bladder imaging. This information will help guide future studies in the use of ultrasound during urodynamics.

Recent Findings

Recently, multiple studies have employed ultrasound to evaluate bladder volume, wall thickness, shape, vibrometry, elastography, compliance, biomechanics, and micromotion during urodynamics. These new techniques have used both 2D and 3D ultrasound techniques to evaluate bladder changes during filling. Continued research is needed to confirm ongoing findings prior to widespread incorporation into clinical practice.

This review demonstrates the potential use of ultrasound as an adjunct to urodynamics for the diagnostic evaluation of functional bladder disorders.
Evidence-based Prostate Cancer Screening Interventions for Black Men: A Systematic Review
Authors: Lopez Abigail , Bailey Jared T. , Galloway Dorothy , Woods-Burnham Leanne , Montgomery Susanne B. , Kittles Rick , Teteh-Brooks Dede K.
Published: July 2024

Prostate cancer is the second leading cause of death for men in the U.S. and Black men are twice as likely to die from the disease. However, prostate cancer, if diagnosed at an earlier stage, is curable. The purpose of this review is to identify prostate cancer screening clinical trials that evaluate screening decision-making processes of Black men.

Methods

The databases PubMed, Ovid MEDLINE, CINAHL Plus, and PsychInfo were utilized to examine peer-reviewed publications between 2017 and 2023. Data extracted included implementation plans, outcome measures, intervention details, and results of the study. The Critical Appraisal Skills Programme was used to assess the quality of the evidence presented.

Results

Of the 206 full-text articles assessed, three were included in this review. Educational interventions about prostate cancer knowledge with shared and informed decision-making (IDM) features, as well as counseling, treatment options, and healthcare navigation information, may increase prostate cancer screening participation among Black men. Additionally, health partner educational interventions may not improve IDM related to screening participation. The quality of the evidence presented in each article was valid and potentially impactful to the community.

Discussion

Black men face various social determinants of health barriers related to racism, discrimination, cost of health services, time away from work, and lack of trust in the healthcare system when making health-related decisions, including prostate cancer screening participation. A multifactorial intervention approach is required to address these inequities faced by Black men especially as prostate cancer is curable when diagnosed at an earlier stage.
Sustainable development goal 12 and its synergies with other SDGs: identification of key research contributions and policy insights
Authors: Raman Raghu , Lathabai Hiran H. , Nedungadi Prema
Published: July 2024

The relationships of SDG 12 (responsible consumption and production) with other sustainable development goals (SDGs), both direct and indirect, necessitate a systematic analysis to understand its pivotal role in achieving other SDGs. This work focuses on a threefold investigation through a scientometric framework. Initially, the study sought to map and analyze the naturally formed linkages between SDG 12 and other SDGs by examining the literature specifically devoted to SDG 12, thereby revealing the SDGs that are strongly linked to SDG 12. The subsequent phase of the investigation identified prominent topics related to SDG 12 that require detailed exploration. Finally, the selected topics are mined through a methodical approach termed flow vergence gradient analysis, allowing for the revelation of significant contributions within each topic. Through the analysis of the SDG linkage map, SDG 13 (climate action), SDG 7 (affordable and clean energy), SDG 11 (sustainable cities and communities), and SDG 15 (life on land), among others, were recognized as closely linked to SDG 12. Following this identification, five major topics—Industrial Symbiosis, Electronic waste, Carbon emissions, Life Cycle Assessment, and Green products—were deemed suitable for comprehensive mining to extract pivotal contributions. As policy recommendations, adopting a multifaceted approach to e-waste management and sustainable practices is imperative. Implementing consumption-based accounting (CBA) to achieve SDG 12 holistically will be useful. Businesses must align with circular economy principles, minimize hazardous materials, and adhere to low-emission, green supply chain practices. The emphasis is also on the need for proactive R&D collaboration with academia to meet SDG 12 targets, alongside engaging in community awareness through corporate social responsibility initiatives.
Inter‐Regional Food‐Water‐Income Synergy Through Bi‐Level Crop Redistribution Model Coupled With Virtual Water: A Case Study of China’s Hetao Irrigation District
Authors: Yin Jieling , Li Xin , Engel Bernie A. , Ding Jiayi , Xing Xin , Sun Shikun , Wang Yubao
Published: July 2024

Incorporating water footprints and virtual water into crop redistribution provides a new approach for efficient water resources utilization and synergistic development of water surplus and scarce regions. In this work, the absolute and comparative advantage of the production‐based blue and gray water footprint (PWFblue and PWFgray), the calorie‐based blue water footprint (CWFblue) and the net benefit‐based blue water footprint (NBWFblue) were used as coefficients to establish a bi‐level crop redistribution model. The mode considers upper‐level decision makers interested in maximizing food security and ecological security and lower‐level decision makers interested in water use efficiency, water use benefits and net benefits. The model was applied in the Hetao Irrigation District (HID), China. The results showed that after optimization, the PWFblue, CWFblue, NBWFblue, and gray water footprint (GWF) of the HID were reduced by 23.32%, 5.60%, 17.40%, and 6.67%, respectively. National benefits were improved, especially when considering synergistic optimization, although the net benefits of HID was affected. The calorie supply increased by 9.6 × 109 kcal, the GWF decreased by 8.29 × 106 m3, and water use efficiency and benefits were improved in China. In contrast, the calorie supply and the net benefits of the HID decreased, while the GWF increased. Moreover, multiple stakeholders were involved in crop redistribution and required national synergies. The bi‐level model proved more suitable than the multi‐objective model. The model proposed in this work considers synergies outside the region in crop redistribution within the region, and can provide new insight for water and soil resources management in arid and semi‐arid regions.
Improved Imaging Offers New Insight into Mount Etna
Authors: Owen Rebecca
Published: July 2024

Anisotropic tomography provides a more complete picture of the Sicilian volcano’s inner workings.
Evaluating the Seasonal Responses of Southern Ocean Sea Surface Temperature to Southern Annular Mode in CMIP6 Models
Authors: Hu Yihang , Tian Wenshou , Dong Yuxin , Zhang Jiankai
Published: July 2024

Using observations and CMIP6 historical simulations, the seasonal responses of Southern Ocean (50°S–70°S) sea surface temperature (SST) to Southern Annular Mode (SAM) variations are investigated in this study. The results suggest that the averaged Southern Ocean SST in austral spring and summer show a significant cooling in response to a positive SAM, while the responses in austral autumn and winter are negligible. The cooling effect is resulted from the cold water in higher latitudes and deeper oceans brought by the equatorward Ekman transport and the Ekman pumping associated with the positive SAM. Among CMIP6 models, the magnitude of the simulated cooling response connects to the climatological meridional and vertical ocean temperature gradients, and the magnitude of Ekman motion in response to SAM. In addition, the spring and summer SAM plays a more important role in modulating Southern Ocean SST in autumn and winter than the autumn and winter SAM.
Vegetation‐Generated Turbulence Does Not Impact the Erosion of Natural Cohesive Sediment
Authors: Deitrick Autumn R. , Ralston David K. , Esposito Christopher R. , Baustian Melissa M. , Burgos Maricel Beltrán , Courtois Andrew J. , Nepf Heidi
Published: July 2024

Previous studies have demonstrated that vegetation‐generated turbulence can enhance erosion rate and reduce the velocity threshold for erosion of non‐cohesive sediment. This study considered whether vegetation‐generated turbulence had a similar influence on natural cohesive sediment. Cores were collected from a black mangrove forest with aboveground biomass and exposed to stepwise increases in velocity. Erosion was recorded through suspended sediment concentration. For the same velocity, cores with pneumatophores had elevated turbulent kinetic energy compared to bare cores without pneumatophores. However, the vegetation‐generated turbulence did not increase bed stress or the rate of resuspension, relative to bare cores. It was hypothesized that the short time‐scale fluctuations associated with vegetation‐generated turbulence were not of sufficient duration to break cohesion between grains, explaining why elevated levels of turbulence associated with the pneumatophores had no impact on the erosion threshold or rate.
Deep Learning‐Based Prediction of Global Ionospheric TEC During Storm Periods: Mixed CNN‐BiLSTM Method
Authors: Ren Xiaochen , Zhao Biqiang , Ren Zhipeng , Wang Yan , Xiong Bo
Published: July 2024

The application of deep learning in high‐precision ionospheric parameter prediction has become one of the focus in space weather research. In this study, an improved model called Mixed Convolutional Neural Networks (CNN)—Bi‐Long Short Term Memory is proposed for predicting future ionospheric Total Electron Content (TEC). The model is trained using the longest available (25 years) Global Ionospheric Maps‐TEC and evaluated the accuracy of ionospheric storm predictions. The results indicate that using historical TEC in the solar‐geographical reference frame as input driving data achieves higher prediction accuracy compared to that in the geocentric coordinate system. Additionally, by comparing different input parameters, it is found that incorporating the Kp, ap, and Dst indices as inputs to the model effectively improves its accuracy, especially in long‐term forecasting where R2 increased by 3.49% and Root Mean Square Error decreased by 13.48%. Compared with BiLSTM‐Deep Neural Networks (DNN) and CNN‐BiLSTM, the Mixed CNN‐BiLSTM model has the highest prediction accuracy. It suggests that the utilization of CNN modules for processing spatial information, along with the incorporation of DNN modules to incorporate geomagnetic indices for result correction. Moreover, in short‐term predictions, the model accurately forecasts the evolution process of ionospheric storms. When extending the predicted length, although there are cases of prediction errors, the model still captures the entire process of ionospheric storms. Furthermore, the predicted results are significantly influenced by longitude, magnetic latitude, and local time.
Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Authors: Hu Lifang , Chen Wei , Qian Airong , Li Yi-Ping
Published: July 2024

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life. Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses. In this review, we provide an update of Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and diseases. The Wnt proteins, receptors, activators, inhibitors, and the crosstalk of Wnt signaling pathways with other signaling pathways are summarized and discussed. We mainly review Wnt signaling functions in bone formation, homeostasis, and related diseases, and summarize mouse models carrying genetic modifications of Wnt signaling components. Moreover, the therapeutic strategies for treating bone diseases by targeting Wnt signaling, including the extracellular molecules, cytosol components, and nuclear components of Wnt signaling are reviewed. In summary, this paper reviews our current understanding of the mechanisms by which Wnt signaling regulates bone formation, homeostasis, and the efforts targeting Wnt signaling for treating bone diseases. Finally, the paper evaluates the important questions in Wnt signaling to be further explored based on the progress of new biological analytical technologies.
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells
Authors: Sousa Alexander A. , Hemez Colin , Lei Lei , Traore Soumba , Kulhankova Katarina , Newby Gregory A. , Doman Jordan L. , Oye Keyede , Pandey Smriti , Karp Philip H. , McCray Paul B. , Liu David R.
Published: July 2024

Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic optimization of PE systems to efficiently correct human cystic fibrosis (CF) transmembrane conductance regulator (CFTR) F508del, a three-nucleotide deletion that is the predominant cause of CF. By combining six efficiency optimizations for PE—engineered PE guide RNAs, the PEmax architecture, the transient expression of a dominant-negative mismatch repair protein, strategic silent edits, PE6 variants and proximal ‘dead’ single-guide RNAs—we increased correction efficiencies for CFTR F508del from less than 0.5% in HEK293T cells to 58% in immortalized bronchial epithelial cells (a 140-fold improvement) and to 25% in patient-derived airway epithelial cells. The optimizations also resulted in minimal off-target editing, in edit-to-indel ratios 3.5-fold greater than those achieved by nuclease-mediated homology-directed repair, and in the functional restoration of CFTR ion channels to over 50% of wild-type levels (similar to those achieved via combination treatment with elexacaftor, tezacaftor and ivacaftor) in primary airway cells. Our findings support the feasibility of a durable one-time treatment for CF.
CALiSol-23: Experimental electrolyte conductivity data for various Li-salts and solvent combinations
Authors: de Blasio Paolo , Elsborg Jonas , Vegge Tejs , Flores Eibar , Bhowmik Arghya
Published: July 2024

Ion transport in non-aqueous electrolytes is crucial for high performance lithium-ion battery (LIB) development. The design of superior electrolytes requires extensive experimentation across the compositional space. To support data driven accelerated electrolyte discovery efforts, we curated and analyzed a large dataset covering a wide range of experimentally recorded ionic conductivities for various combinations of lithium salts, solvents, concentrations, and temperatures. The dataset is named as ’Conductivity Atlas for Lithium salts and Solvents’ (CALiSol-23). Comprehensive datasets are lacking but are critical to building chemistry agnostic machine learning models for conductivity as well as data driven electrolyte optimization tasks. CALiSol-23 was derived from an exhaustive review of literature concerning experimental non-aqueous electrolyte conductivity measurement. The final dataset consists of 13,825 individual data points from 27 different experimental articles, in total covering 38 solvents, a broad temperature range, and 14 lithium salts. CALiSol-23 can help expedite machine learning model development that can help in understanding the complexities of ion transport and streamlining the optimization of non-aqueous electrolyte mixtures.
Boundaries of task-specificity: bimanual finger dexterity is reduced in musician’s dystonia
Authors: Sadnicka Anna , Wiestler Tobias , Butler Katherine , Altenmuller Eckart , Edwards Mark J. , Ejaz Naveed , Diedrichsen Jörn
Published: July 2024

Task-specific dystonia leads to loss of sensorimotor control for a particular motor skill. Although focal in nature, it is hugely disabling and can terminate professional careers in musicians. Biomarkers for underlying mechanism and severity are much needed. In this study, we designed a keyboard device that measured the forces generated at all fingertips during individual finger presses. By reliably quantifying overflow to other fingers in the instructed (enslaving) and contralateral hand (mirroring) we explored whether this task could differentiate between musicians with and without dystonia. 20 right-handed professional musicians (11 with dystonia) generated isometric flexion forces with the instructed finger to match 25%, 50% or 75% of maximal voluntary contraction for that finger. Enslaving was estimated as a linear slope of the forces applied across all instructed/uninstructed finger combinations. Musicians with dystonia had a small but robust loss of finger dexterity. There was increased enslaving and mirroring, primarily during use of the symptomatic hand (enslaving p = 0.003; mirroring p = 0.016), and to a lesser extent with the asymptomatic hand (enslaving p = 0.052; mirroring p = 0.062). Increased enslaving and mirroring were seen across all combinations of finger pairs. In addition, enslaving was exaggerated across symptomatic fingers when more than one finger was clinically affected. Task-specific dystonia therefore appears to express along a gradient, most severe in the affected skill with subtle and general motor control dysfunction in the background. Recognition of this provides a more nuanced understanding of the sensorimotor control deficits at play and can inform therapeutic options for this highly disabling disorder.
Origin of asteroid (101955) Bennu and its connection to the New Polana family
Authors: Takir Driss , Emery Joshua P. , Bottke William F. , Arredondo Anicia
Published: July 2024

The asteroid (142) Polana is classified as a B-type asteroid located in the inner Main Belt. This asteroid is the parent of the New Polana family, which has been proposed to be the likely source of primitive near-Earth asteroids such as the B-type asteroid (101955) Bennu. To investigate the compositional correlation between Polana and Bennu at the 3 µm band and their aqueous alteration histories, we analyzed the spectra of Polana in the ~ 2.0–4.0 µm spectral range using the NASA Infrared Telescope Facility in Hawai’i. Our findings indicate that Polana does not exhibit discernable 3 µm hydrated mineral absorption (within 2σ), which is in contrast to asteroid Bennu. Bennu displayed a significant 3 µm absorption feature similar to CM- and CI-type carbonaceous chondrites. This suggests two possibilities: either Bennu did not originate from the New Polana family parented by asteroid Polana or the interior of Bennu’s parent body was not homogenous, with diverse levels of aqueous alteration. Several explanations support the latter possibility, including heating due to shock waves and pressure, which could have caused the current dehydrated state of Bennu’s parent body.
Cultural differences in wine conceptualization among consumers in France, Portugal and South Africa
Authors: Fairbairn Samantha , Brand Jeanne , Ferreira Antonio Silva , Valentin Dominique , Bauer Florian
Published: July 2024

Consumers’ mental pictures of wine are multifaceted and are shaped by their sensory (taste, smell, visual, sensation) perceptions, in addition to emotional, cultural and extrinsic (brand, price, and awards) influences. This study explores whether consumers from three different wine cultures share mental representations of three wine concepts. Through an online survey, French, Portuguese, and South African wine consumers described their conceptualizations of Wine, Red wine and White wine aroma. Given these nations’ rich winemaking traditions and diverse wine styles, differences in consumer perspectives were likely to emerge. The findings demonstrate that, regardless of cultural background, the broad concept of Wine aligns with the more specific Red and White wine conceptualizations, although the latter concepts diverge from each other. Notably, cultural contexts significantly influence participants’ representations of Red Wine, with particularly marked contrasts between the South African and French respondents. This suggests that like experts, wine consumers have also built representations of wine through semantic memory. This cross-cultural analysis of consumer interpretations of wine concepts holds the potential for refining marketing strategies to overcome cultural barriers in wine purchasing behaviour.
Habitat radiomics and deep learning fusion nomogram to predict EGFR mutation status in stage I non-small cell lung cancer: a multicenter study
Authors: Wu Jingran , Meng Hao , Zhou Lin , Wang Meiling , Jin Shanxiu , Ji Hongjuan , Liu Bona , Jin Peng , Du Cheng
Published: July 2024

Develop a radiomics nomogram that integrates deep learning, radiomics, and clinical variables to predict epidermal growth factor receptor (EGFR) mutation status in patients with stage I non-small cell lung cancer (NSCLC). We retrospectively included 438 patients who underwent curative surgery and completed driver-gene mutation tests for stage I NSCLC from four academic medical centers. Predictive models were established by extracting and analyzing radiomic features in intratumoral, peritumoral, and habitat regions of CT images to identify EGFR mutation status in stage I NSCLC. Additionally, three deep learning models based on the intratumoral region were constructed. A nomogram was developed by integrating representative radiomic signatures, deep learning, and clinical features. Model performance was assessed by calculating the area under the receiver operating characteristic (ROC) curve. The established habitat radiomics features demonstrated encouraging performance in discriminating between EGFR mutant and wild-type, with predictive ability superior to other single models (AUC 0.886, 0.812, and 0.790 for the training, validation, and external test sets, respectively). The radiomics-based nomogram exhibited excellent performance, achieving the highest AUC values of 0.917, 0.837, and 0.809 in the training, validation, and external test sets, respectively. Decision curve analysis (DCA) indicated that the nomogram provided a higher net benefit than other radiomics models, offering valuable information for treatment.
Administration of an antibody against apoptosis inhibitor of macrophage prevents aortic aneurysm progression in mice
Authors: Fujii Taro , Yamawaki-Ogata Aika , Terazawa Sachie , Narita Yuji , Mutsuga Masato
Published: July 2024

Apoptosis inhibitor of macrophage (AIM) is known to induce apoptosis resistance in macrophages and to exacerbate chronic inflammation, leading to arteriosclerosis. The role of AIM in aortic aneurysm (AA) remains unknown. This study examined the effects of an anti-AIM antibody in preventing AA formation and progression. In apolipoprotein E-deficient mice, AA was induced by subcutaneous angiotensin II infusion. Mice were randomly divided into two groups: (i) AIM group; weekly anti-murine AIM monoclonal antibody injection (n = 10), and (ii) IgG group; anti-murine IgG antibody injection as control (n = 14). The AIM group, compared with the IgG group, exhibited reduced AA enlargement (aortic diameter at 4 weeks: 2.1 vs. 2.7 mm, respectively, p = 0.012); decreased loss of elastic lamellae construction; reduced expression levels of IL-6, TNF-α, and MCP-1; decreased numbers of AIM-positive cells and inflammatory M1 macrophages (AIM: 1.4 vs. 8.0%, respectively, p = 0.004; M1 macrophages: 24.5 vs. 55.7%, respectively, p = 0.017); and higher expression of caspase-3 in the aortic wall (22.8 vs. 10.5%, respectively, p = 0.019). Our results suggest that administration of an anti-AIM antibody mitigated AA progression by alleviating inflammation and promoting M1 macrophage apoptosis.