bluuebunny/crossref_metadata_2025 huggingface dataset:
Olokizumab in patients with inflammatory phenotype of osteoarthritis, treatment experience
Authors: Lila A. M. , Alekseeva L. I. , Taskina E. A. , Kashevarova N. G. , Sharapova E. P. , Strebkova E. A. , Savushkina N. M. , Khalmetova A. R. , Nesterenko V. A. , Avdeeva A. S. , Samarkina E. Yu. , Diatroptov M. E. , Alekseeva O. G.
Published: June 2024

Objective: to investigate the efficacy and safety of olokizumab (OKZ) in patients with knee osteoarthritis (OA) with synovitis, persistent pain and ineffectiveness of previous conservative therapy.

   Material and methods. The study included 15 patients with stage II–III knee OA who fulfilled the ACR criteria and had pain ≥50 mm on a visual analogue scale (VAS), synovitis and treatment failure. The age of patients ranged from 54 to 75 years; the duration of the disease was from 1 to 23 years. The duration of the study was 12 weeks, during which the patients received 3 subcutaneous injections of OKZ at a dose of 64 mg. The effectiveness of the treatment was assessed by the dynamics of pain intensity according to VAS, WOMAC and KOOS indices, the values of the DN4 questionnaire and the quality of life according to EQ-5D. In addition, the general assessment of the patient's health (GHA) according to VAS, the assessment of treatment efficacy by doctor and patient and the need for non-steroidal anti-inflammatory drugs (NSAIDs) were considered. All patients underwent laboratory testing.

   Results and discussion. During treatment, there was a significant decrease in pain intensity according to VAS, a statistically significant improvement in the KOOS and WOMAC indices (p<0.05), quality of life according to the EQ-5D questionnaire and GHA. Patients and doctors rated the treatment results very positively: an improvement or significant improvement was observed in 92.3% of cases. Adverse events were identified in 4 patients, which in 2 cases served as the reason for discontinuation of OKZ treatment and termination of participation in the study. During treatment with OKZ, a statistically significant decrease in CRP and ESR values, an increase in the concentration of interleukin 6 (p = 0.003), COMP (p = 0.03) and PIINP (p = 0.01) were observed.

   Conclusion. The results obtained suggest a significant symptomatic and anti-inflammatory effect of OKZ in patients with the inflammatory phenotype of OA.
Management of patients with infective endocarditis: current state-of-art. Part I: clinical picture, diagnosis, differential diagnosis
Authors: Belov B. S. , Tarasova G. M. , Muravyova N. V.
Published: June 2024

The problem of infective endocarditis (IE) remains relevant due to the high mortality rate and the development of severe complications. IE is a polyetiological disease, the occurrence and development of which can be caused by an extremely extensive list of pathogens, which is replenished almost annually. The pronounced clinical polymorphism of IE determines the importance of its early diagnosis, including the use of new medical technologies. Timely informing physicians about the modern principles of monitoring of patients with IE is of great practical importance. Part I of the article describes the clinical features, basic principles of diagnosis and differential diagnosis of IE, taking into account the recommendations of the European Society of Cardiology 2023.
Identification of patterns of microbiota influence on the pathogenetic mechanisms of systemic lupus erythematosus development
Authors: Shaykhutdinova A. A. , Burbeza D. A. , Strelchenko S. I. , Fathallah K. , Rayevsky K. P.
Published: June 2024

Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease characterized by multisystem involvement. Although the pathogenesis of SLE is not fully understood, numerous studies have shown that the composition of the microbiota can influence the course of the disease. The microbiota plays a key role in the development of immune defense and is an integral part of immune homeostasis. Dysbiosis of the intestinal, oral and vaginal microbiota can have a significant impact on the development of inflammatory and autoimmune diseases. The review addresses recent studies on the microbiota, with a particular focus on changes in the composition of the gut microbiota and their impact on SLE. Data from several studies suggest that there is a link between SLE and certain patterns of dysbiosis.
Secondary fibromyalgia in children with immune-inflammatory rheumatic diseases
Authors: Santimov A. V. , Grechanyi S. V. , Novik G. A.
Published: June 2024

Patients with immune-inflammatory rheumatic diseases (IIRDs) often present with non-inflammatory musculoskeletal pain associated with nociceptive dysfunction, central sensitization, and secondary fibromyalgia (FM). In recent years, an increasing number of publications have appeared dealing with FM in rheumatoid arthritis and systemic connective tissue diseases in adult patients, while this problem is little discussed in pediatric rheumatology, partly due to the differences between the existing diagnostic criteria in children and adults, which complicate the diagnosis of juvenile secondary FM. The consequence of this is often the unfounded prescription or switching of synthetic disease-modifying antirheumatic drugs (DMARDs) or biologic DMARDs in patients who do not require intensified antirheumatic therapy, but rather psychotherapy and psychopharmacotherapy, as well as the wider use of physical and rehabilitation medicine methods. In a brief narrative review, we tried to trace the investigation of FM in a rheumatological clinic, including children with IIRD, from a historical perspective, to summarize current literature data on this problem and to point out possible solutions.
Strategy Rehabilitation and Management of Mangrove Based on SWOT Analysis in Betahwalang Village Bonang, Bonang Sub-District, Demak Regency, Central Java.
Authors: Rahmawati Hanik , Pribadi Rudhi , Santoso Adi
Published: June 2024

The mangrove ecosystem in Demak District can be found one of them in Betahwalang Village, Bonang Sub District. Betahwalang Village. The management of mangrove ecosystem that is not environmentally friendly, especially in the village Betahwalang, District Bonang, Demak District This can certainly threaten the coastal area. The purpose of this study is to recommend a strategy of continuing rehabilitation and mangrove forest management in Betahwalang Village, Bonang Sub-district, Demak Regency, Central Java. This study was held in March-April 2019 in Betahwalang Village, Bonang Sub-district, Demak Regency, Central Java using descriptive method explorative. Based on the results of research obtained rehabilitation strategy and management of mangrove forest in Betahwalang Village produced 5 (five) priority is (1) active participation of the community in the efforts of mangrove rehabilitation (2) implementation Systems that are more structured for farmer groups such as the record of mangrove planting data (3) synergy between village regulations with local regulations in the efforts of mangrove rehabilitation (4) optimizing cooperation between Government and non-governmental institutions Government in the management of mangrove forests and efforts to professionals mangrove forest (5) utilization of technology and information in the management of mangrove and garbage in the area of mangrove forest.
Human Catalase, Its Polymorphisms, Regulation and Changes of Its Activity in Different Diseases
Authors: Kodydková Jana , Vávrová L. , Kocík M. , Žák A.
Published: June 2024

Catalase (CAT) is a well-studied enzyme that plays an important role in protecting cells against the toxic effects of hydrogen peroxide. In human, it has been implicated in different physiological and pathological conditions. This review summarizes the information available on the function and role of CAT polymorphisms in pathogenesis of various pathophysiological states as well as on the regulation ofCATgene expression. Numerous studies have described the CAT polymorphisms and their link with various diseases. Changes in the CAT levels were reported in many different diseases and polymorphisms in theCATgene were shown to be associated with different pathophysiological states, e.g. hypertension, diabetes mellitus, insulin resistance, dyslipidaemia, asthma, bone metabolism or vitiligo. Regulation of theCATgene expression plays an important role in the levels of CAT. The catalase gene expression is regulated by various mechanisms involving e.g. peroxisome proliferator-activated receptor γ (PPARγ), tumour necrosis factor α (TNF-α), p53 protein and hypermethylation of CpG islands in the catalase promoter. Transcription of theCATgene is mainly influenced by the -262 C/T and -844 A/G polymorphisms. A common polymorphism -262 C/T in the promoter region has been found to be associated with altered CAT activities. Apart from genetic factors, the activities of CAT may be affected by age, seasonal variations, physical activity, or a number of chemical compounds. Future investigations are necessary to elucidate the role of CAT in pathogenesis of oxidative stress-related diseases.
Wyzwania rodzicielskie w ponowoczesności
Authors: Bakiera Lucyna
Published: June 2024

Contemporary parents in Western culture operate within the context of social processes such as globalization, consumerism, relativism, individualism, and mediatization. These processes are manifestations of postmodernity, which significantly weakens the influence of tradition on the life choices of adults. Engagement in clearly defined and institutionalized roles, including parental roles,does not align with the postmodern lifestyle. Postmodernity presents mothers and fathers with numerous tasks on their journey to realizing personal parenting projects. Modern motherhood and fatherhood roles show considerable diversity – ranging from maintaining traditional forms, to adopting egalitarian approaches, to entirely new and individualized methods of parenting. This article serves as an introduction to a series of original discussions addressing the current challenges faced by parents.
Transglutaminase 2 knockout mice are protected from bleomycin‐induced lung fibrosis with preserved lung function and reduced metabolic derangements
Authors: Freeberg Margaret A. T. , Thatcher Thomas H. , Camus Sarah V. , Huang Linghong , Atkinson John , Narrow Wade , Haak Jeannie , Dylag Andrew M. , Cowart L. Ashley , Johnson Timothy S. , Sime Patricia J.
Published: June 2024

Pulmonary fibrosis is an interstitial scarring disease of the lung characterized by poor prognosis and limited treatment options. Tissue transglutaminase 2 (TG2) is believed to promote lung fibrosis by crosslinking extracellular matrix components and activating latent TGFβ. This study assessed physiologic pulmonary function and metabolic alterations in the mouse bleomycin model with TG2 genetic deletion. TG2‐deficient mice demonstrated attenuated the fibrosis and preservation of lung function, with significant reduction in elastance and increases in compliance and inspiratory capacity compared to control mice treated with bleomycin. Bleomycin induced metabolic changes in the mouse lung that were consistent with increased aerobic glycolysis, including increased expression of lactate dehydrogenase A and increased production of lactate, as well as increased glutamine, glutamate, and aspartate. TG2‐deficient mice treated with bleomycin exhibited similar metabolic changes but with reduced magnitude. Our results demonstrate that TG2 is required for a typical fibrosis response to injury. In the absence of TG2, the fibrotic response is biochemically similar to wild‐type, but lesions are smaller and lung function is preserved. We also show for the first time that profibrotic pathways of tissue stiffening and metabolic reprogramming are interconnected, and that metabolic disruptions in fibrosis go beyond glycolysis.
A systematic review of recent developments in IoT-based demand side management for PV power generation
Authors: Rao Challa Krishna , Sahoo Sarat Kumar , Yanine Franco Fernando
Published: June 2024

Demand-side management (DSM) with Internet of Things (IoT) integration has become a vital path for optimizing photovoltaic (PV) power generating systems. This systematic review synthesizes and evaluates the latest advancements in IoT-based DSM strategies applied to PV power generation. The review encompasses a comprehensive analysis of recent literature, focusing on the key elements of IoT implementation, data analytics, communication protocols, and control strategies in relation to solar energy DSM. The combined results show how IoT-driven solutions are changing and how they might improve PV power systems’ sustainability, dependability, and efficiency. The review also identifies gaps in current research and proposes potential avenues for future investigations, thereby contributing to the ongoing discourse on leveraging smart DSM in the solar energy domain using IoT technology.
Influence of medical didactic training on the self-efficacy and motivation of clinical teachers
Authors: Schydlo Franziska , Sterz Jasmina , Stefanescu Maria-Christina , Kadmon Martina , König Sarah , Rüsseler Miriam , Walcher Felix , Adili Farzin
Published: June 2024

Objectives

Due to increasing workload and rising expectations for both undergraduate and speciality training in medicine, teaching in a clinical environment can be challenging. The “Train the Trainer” course, developed by CAL (Chirurgische Arbeitsgemeinschaft Lehre, Deutsche Gesellschaft für Chirurgie (DGCH)), aims to assist clinical teachers in their task. This study investigates the effect the course has on participants’ self-efficacy and teaching motivation.

Methods

Prior to attending the course, participants anonymously completed a 50-question pre-course questionnaire using standardised questions to gather information on biographical data teaching experience, and validated tools measuring teaching motivation and self-efficacy (PRE). Directly after completing the course, participants evaluated it using a 25-question post-course questionnaire (POST1). At least 12 months after the course, participants received a follow-up questionnaire (POST2) by mail. This 44-question form aimed to gather biographical data, review the teaching methods participants had used since their training, and reassess their teaching motivation and self-efficacy.

Results

Between June 2016 and October 2019, 20 TTT courses were held across six German medical faculties. Data were gathered from 241 participants. After the course, 182 POST2 questionnaires were mailed, 61 of which were returned (equals a 39 % return rate). The findings revealed significant increases in teacher self-efficacy (p=0.0025), identified regulation (p=0.0000), and career motivation (p=0.0044). In contrast, there was a significant decrease in introjected regulation (p=0.0048). When comparing the participants to a reference sample selected from literature, significant differences emerged in intrinsic motivation (p=0.0000) and amotivation (p=0.0025).

Conclusions

Course participants already showed strong intrinsic motivation and self-efficacy before taking the course. After completing it, their confidence to meet specific teaching demands based on their abilities had increased. Notably, changes in motivational dimensions identified and introjected regulation point towards a shift in motivational sources, indicating a more self-regulated approach towards participants’ teaching activities. Further research is needed to determine how much of this change was due to course participation.
Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
Authors: Pang Long , Gao Zhihui , Ma Long , Li Yaping , Lu Zhidong , Zhang Liang , Li Peng , Wu Long
Published: June 2024

The bleeding time and amount in the short-segment group were shorter than in the long-segment group, and the bleeding volume was less than in the long-segment group. The Japanese Orthopaedic Association low back pain score, Oswestry Dysfunction Index, and lumbar spine stiffness disability index score of the two groups were significantly improved preoperatively, postoperatively, and at 6 months, 1 year, and 2 years post-operation. The differences were statistically significant at different time points within the groups. Neurological function improved to varying degrees postoperatively. The Cobb angle was significantly higher in both groups (P < 0.05). Adjacent vertebral disease occurred in 10 of 64 patients with short-segment fixation, with a prevalence of 15.6%. Preoperative pelvic tilt angle, preoperative pelvic projection angle (PPA), preoperative degree of matching of PPA to LL (PI-LL), and preoperative coronal Cobb angle were higher in patients with adjacent vertebral disease. There were varying degrees of improvement in low back pain and spinal function after short-segment decompression and fusion internal fixation. However, the patients are generally elderly and at risk of persistent low back pain and accelerated degeneration of adjacent segments.
Do Logical Aliens Think? Frege’s Agent-Relative View of Logic’s Constitutive Role for Thinking
Authors: Willert Kristoffer Balslev
Published: June 2024

Must you respect basic logical laws (BLL) – such as the law of non-contradiction – in order to think? Frege wrote that one must “acknowledge” BLL in order not to “abandon judgement altogether”. Some have argued that Frege therefore thought of logic as somehow ‘constitutive’ of thinking. However, some interpreters contend, due to his strong commitment to logic’s normative status, that Frege held the opposite view, namely the non-constitutivist view that (systematic) ‘illogical’ thinking is possible and that one need not accept or follow BLL in order to think as such, although one must do so in order to think correctly. The aim of this paper is to investigate the interpretative landscape regarding Frege’s view on logic’s constitutive role for thinking and suggest, against the non-constitutivist readings, that he indeed was committed to some version of the constitutivity thesis, but that this commitment is not, as some constitutivist interpretations suggest, inconsistent with the idea that logic is normative for thinking. I will, instead, propose to read his view in a soft and agent-relative sense, according to which it is a necessary condition for the possibility of thinking that the agent in question is sensitive to and acknowledges BLL.
Son Devir Osmanlı Şairlerinden Mısırlızâde Ali Celâleddîn Efendi ve Dîvânçe’si
Authors: Parlakkılıç Mucan Ayşe
Published: June 2024

Kayseri’nin Develi ilçesinde doğan Mısırlızade Ali Celaleddin Efendi son devir Osmanlı şairlerindendir. Develi’de medrese tahsili gören Mısırlızade; Seb’a, Sincar ve Resûlâyîn nahiyelerinde naiplik; Rakka, Leş, Tabriye, Hadim, Erbaa, Kevar’ da kadılık yapmıştır. Hayli hareketli geçen memuriyet hayatının ardından 1908 yılında emekli olup memleketi Develi’ye dönmüş ve 1909 yılında burada vefat etmiştir. Kaynaklarda Mısırlızade’ye ait bir divandan bahsedilmişse de yakın bir zaman kadar esere ulaşılamamıştır. 2019 yılında Kasım Kocabaş isimli bir araştırmacı bu eseri Niğde’de bir sahaftan satın aldığını, Kadir Özdamarlar ile eser üzerinde çalışacaklarını beyan etmiştir. Ancak böyle bir çalışma ortaya konmamıştır. 2023 yılı sonunda Konya’da bir sahafta tesadüf eseri bulduğumuz bu eser satın alınarak kütüphanemize kazandırılmıştır. Bu çalışma, Osmanlı’nın son devir kadı şairlerinden Mısırlızade Ali Celaleddin Efendi’yi, onun ulaşılabilen tek eseri olan ve hakkında henüz akademik bir çalışma bulunmayan Divançe’ sini tanıtmayı amaçlamaktadır. Bu amaçla öncelikle Mısırlızade Ali Celaleddin Efendi’nin hayatı ile ilgili bilgilere yer verilmiş, akabinde Mısırlızade Divançe’si nüsha, dil ve üslup özellikleri, tertip şekli ve muhteva özellikleri cihetiyle tanıtılmıştır. Çalışmalarımız neticesinde eserde 150’den fazla şiirin yer aldığı görülmüş, klasik tertibe göre düzenlenmeyen nüshanın şairin farklı zamanlarda kaleme aldığı bir defter görünümünde olduğu anlaşılmıştır. Divan şiiri nazım biçimlerinin yanı sıra koşma, kalenderî, semai gibi Türk Halk şiiri nazım formlarının da yer aldığı bu eserle Mısırlızade’nin hayatına dair bilgiler elde edilmiştir. Divançe metninin tamamının neşri ile klasik Türk edebiyatı metin çalışmalarına yeni bir eser daha kazandırılmış olacaktır.
Impact of parental body mass index at diagnosis on obesity in survivors of pediatric craniopharyngioma
Authors: Beckhaus Julia , Eveslage Maria , Bison Brigitte , Friedrich Carsten , Müller Hermann L
Published: June 2024

Objective

It is well known that both genetic background and lifestyle influence the development of ‘general’ obesity. However, the role of parental body mass index (BMI) on the development of obesity in long-term survivors of childhood-onset craniopharyngioma (CP) is not well understood. This study analyzed the correlation of patients’ BMI at diagnosis and last visit and parental BMI at CP diagnosis and further explored potential risk factors for obesity in CP patients.

Design

This is a registry-based retrospective cohort study.

Methods

In total,291 CP patients and their parents recruited in the German KRANIOPHARYNGEOM studies were included. Correlations between patient’s BMI SDS at CP diagnosis and last visit and parental BMI at CP diagnosis were analyzed. The associations between hypothalamic damage, maternal/paternal BMI and CP patients’ obesity at last visit were analyzed by multivariable logistic regression.

Results

At follow-up, 52% of CP patients developed obesity (BMI > 3SDS). Patient’s BMI SDS at last visit was moderately correlated with BMI-SDS at CP diagnosis (r = 0.48, 95% CI: 0.38–0.58, P < 0.001), and also with maternal BMI at diagnosis (r = 0.28, 95% CI: 0.17–0.38, P < 0.001) and paternal BMI at diagnosis (r = 0.3, 95% CI: 0.19–0.41, P < 0.001). However, the contributing role of parental BMI to the pathogenesis of obesity was small compared to the impact of hypothalamic damage.

Conclusion

We conclude that besides hypothalamic damage, parental disposition for obesity is associated with the development of obesity in patients after CP. Our results indicate that also the family situation could have an influence on the development of obesity after CP and might be a therapeutic target.

Significance statement

Survivors of childhood-onset craniopharyngioma are at risk of developing morbid obesity. So far, patients with posterior hypothalamic involvement and lesion were identified as a high risk group. With this study, the influence of parental body mass index on the risk of obesity was investigated. Patient’s body-mass-index at last visit was correlated with maternal and paternal body mass index at diagnosis. With increasing maternal or paternal body mass index, the likelihood of obesity in individuals with CP increased. Nevertheless, the parents’ weight had only a small effect on the development of patients’ obesity compared to hypothalamic damage.
Editorial
Authors: Editor UJP
Published: June 2024

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Birds from human-modified Atlantic Forest landscapes of the middle-lower Paraíba do Sul River basin, southeastern Brazil
Authors: Tavares Gabriel Magalhães , Alves Sandro Leonardo
Published: June 2024

The Atlantic Forest is a highly diverse and threatened ecosystem that has been signiﬁcantly reduced and degraded by human activities. This study provides a comprehensive inventory of bird species inhabiting the human-modiﬁed Atlantic Forest landscapes within the municipalities of Estrela Dalva and Volta Grande in the state of Minas Gerais, situated in the middle-lower Paraíba do Sul River basin, Brazil. Our data encompass non-systematic visual and audio records supplemented by MacKinnon lists collected between 2013 and 2019. Our survey identiﬁed 175 bird species, representing 54 families and 21 orders, including one species regionally categorized as Vulnerable and two species globally categorized as Near Threatened. Among the recorded species, 8.6% exhibited partially migratory habits, while 9.4% of the resident species were endemic to the Atlantic Forest. These ﬁndings underscore the critical importance of preserving forest fragments within historically degraded regions, such as the landscapes along the Paraíba do Sul River basin.
RELACIÓN DE DEPRESIÓN, TEJIDO MUSCULAR Y ADIPOSO EN UNIVERSITARIOS SEDENTARIOS Y DEPORTISTAS
Authors: Orozco Vargas Arturo Enrique , García López Georgina Isabel , Aguilera Reyes Ulises
Published: June 2024

En el presente artículo se determino la asociación entre con el porcentaje de grasa corporal y muscular en función de la conducta depresiva y actividad física en jóvenes universitarios. La muestra fue de 146 hombres y 160 mujeres del Centro Universitario UAEM Atlacomulco, Estado de México, México, a los que se les registró la actividad física, peso (kg), porcentaje de grasa corporal y muscular y se les aplicó el Inventario de Depresión de Beck, para analizar el efecto de la depresión y actividad física sobre los tejidos, se realizó un análisis de ANOVA. Encontrando que existieron diferencias significativas entre la grasa total y la masa muscular entre los diferentes niveles de depresión, presentando mayor grasa abdominal y menor masa muscular los jóvenes con depresión, los jóvenes que practican deporte presentan mayor masa muscular y menor depresión. Los datos apoyan la tendencia de que existe una disminución de masa muscular asociada con la depresión en jóvenes universitarios y el deporte es sustento de desarrollo de masa muscular y protector de salud mental, la falta de masa muscular y práctica deportiva en esta muestra aumenta la posibilidad de sobrepeso, fatiga y otros trastornos psicológicos.
LA PERIODIZACIÓN TÁCTICA: UNA REVISIÓN SISTEMÁTICA
Authors: Murillo Garcia Cristian Marino
Published: June 2024

La periodización táctica corresponde a un planteamiento integral para la planificación del entrenamiento deportivo y que cada vez más es usado en el entrenamiento de los deportes de conjunto. Esta surgió en los años ochenta, propuesta por el profesor portugués Vitor Frade, nace, porque para la opinión del autor, los modelos existentes que eran tomados de otros deportes, por lo que no eran los más aptos para el complejo juego del fútbol. Este estudio se llevó a cabo siguiendo los “elementos de informes preferidos para las revisiones sistemáticas y meta-análisis (PRISMA)." Incluyó artículos experimentales originales que prueban la el modelo en diferentes enfoques y en cualquier deporte, dejando a un lado el nivel o contexto, además de tesis de grado, los estudios revisados fueron en español. La periodización táctica existe desde hace más de 30 años; sin embargo, se ha popularizado más en los últimos años y entrenadores de alto perfil defienden sus metodologías. Aquí se revisaron estudios para demostrar mejoras a nivel cualitativo y cuantitativo, además, puede ser aplicado por equipos de élite y subélite para prepararse de manera más eficaz para partidos competitivos.
CALIDAD DE SUEÑO Y PERFIL ANTROPOMÉTRICO SEGÚN EL NIVEL DE ACTIVIDAD FÍSICA EN ESTUDIANTES UNIVERSITARIOS
Authors: Franco Vélez Gloria Elena , García Cardona Diana Maria , Giraldo Barrios Sergio David , Castillo Miguel Ángel
Published: June 2024

Objetivo: Determinar la calidad de sueño y el perfil antropométrico según el nivel de actividad física de estudiantes de la Universidad del Quindío. Metodología: El estudio fue de tipo descriptivo, no experimental, cuantitativo de corte transversal. Los sujetos fueron divididos en el Grupo Físicamente Activos (GFA) y Grupo Poco Activos (GPA), a ambos grupos se les realizó evaluaciones antropométricas y se les aplicó el cuestionario de Índice de Calidad del Sueño de Pittsburgh (PSQI). Resultados: El grupo GPA pasa aproximadamente 5,8 horas en posición sedente, respecto al perímetro abdominal, ICC e ICA, ambos grupos mostraron valores ubicados en bajo riesgo cardiovascular. En la categoría de calidad del sueño (calificada como bastante buena y muy buena), eficiencia habitual del sueño (mayor al 85%), perturbación del sueño (de una a dos veces por semana), y el uso de medicamentos para dormir (tres o más veces), el GFA, presentó 71%, 60, 19%, 0% respectivamente en relación con los reportados en GPA (56%, 42,8%, 47,6% y 23,8% respectivamente). Conclusión: los hallazgos subrayan la importancia de fomentar la actividad física para mejorar la calidad del sueño y destacan los riesgos asociados con la inactividad física en el bienestar general de los estudiantes.
PROGRAMA DE ACTIVIDAD FÍSICA ATR PARA LOS HÁBITOS DE VIDA SALUDABLE
Authors: Contreras Jauregui Fabian Andrés , Bautista Rico Cristian Alberto , Leal Moreno Oscar Manuel
Published: June 2024

La investigación tuvo como objetivo determinar la relación que tienen los factores asociados al estilo de vida saludable después de la implementación de un programa integral de actividad física en trabajadores de la empresa Empopamplona S.A; El método fue de enfoque cuantitativo, de tipo aplicado y concluyente; se destinó a una muestra intencionada de 15 trabajadores; se realizó un pretest y un post test para evaluar las diferencias después de implementar el programa de entrenamiento que tuvo una duración de ocho semanas; Los hallazgos más representativos evidenciaron que dentro de las variables más importantes como el VO2 max, los datos de la dinamometría manual para mano derecha y para mano izquierda, la presión arterial diastólica y sistólica y la Prueba IPAQ se obtuvo una mejoría en comparación a los resultados iniciales demostrando que el estilo de vida saludable y la actividad física son fundamentales para suprimir los riesgos de enfermedades.
The Role of Pelvic Floor Muscle Exercise in Erectile Dysfunction
Authors: Kim Kwang Lae
Published: June 2024

PURPOSE: This study aimed to determine the role or applicability of pelvic floor muscle exercise for erectile dysfunction.METHODS: This narrative review was conducted by searching terms such as “erectile dysfunction”, “erection dysfunction”, “sexual dysfunction”, and “pelvic floor muscle training”, “pelvic floor muscle exercise”, “pelvic floor exercise”, “randomized controlled trials”, “randomized clinical trials” in PubMed, Google Scholar, Scopus, and Web of Science.RESULTS: Seven articles met the inclusion criteria. Six studies applied pelvic floor muscle exercise, electrical stimulation, and biofeedback treatment to patients with erectile dysfunction after radical prostatectomy. Only three studies showed that treatment in the intervention group had a significant effect on erectile function. Considering these results, the study subjects who applied the three treatment methods presented above were mainly patients with erectile dysfunction caused by prostate cancer surgery.CONCLUSIONS: Seven randomized controlled trials showed no significant effect of pelvic floor muscle exercise on erectile dysfunction. However, they are thought to have applicability as a method for treating erectile dysfunction. In studies of erectile dysfunction caused by radical prostatectomy, homogeneity in the age, duration of erectile dysfunction, and nerve-sparing surgery should be ensured between the intervention and control groups. First, future clinical research is required to determine whether existing methods and concurrent treatment with drugs, such as sildenafil (Viagra) and tadalafil (Cialis) can shorten the recovery period of erectile function. Second, clinical research is needed to analyze the differences in changes in erectile function between those performing aerobic exercise and pelvic floor muscle exercise combined and those performing only pelvic floor muscle exercise.
Role of Core-Based Exercises in Improving Proprioception among Individuals with Neurological Disorders: A Systematic Literature Review and Meta-Analysis
Authors: Lee Hyeong-Chan , Lee Jae-Hoon , Ha Min-Seong
Published: June 2024

PURPOSE: This study aimed to validate the effect of core-based exercise on proprioception in individuals with neurological disorders through a systematic review and meta-analysis.METHODS: A systematic literature search was conducted using databases such as PubMed, Web of Science, and Scopus for studies published up to October 10, 2023. The search yielded 1,945 articles, with seven studies ultimately included for in-depth analysis. Meta-analysis was performed using Review Manager 5.4 software. Standardized mean differences (SMDs) were calculated using Hedges’ g value using both random-effects and fixed-effects models.RESULTS: The meta-analysis revealed that core-based exercise significantly improved joint position sense (SMD = -1.33; 95% confidence interval [CI] = -2.09 to -0.57; I²= 0%; p < .001) and kinesthesia (SMD = -0.33; 95% CI = -0.62 to -0.05; I²= 0%; p < .05) in individuals with neurological disorders. In a sub-analysis by the type of neurological disease, core-based exercises were beneficial only for stroke patients (SMD = -1.05; 95% CI = -2.07 to -0.03; I²= 58%; p < .05), but not for those with Parkinson’s disease or chorea. An analysis by the type of core exercise showed that core stability exercises had a significant benefit (SMD = -0.55; 95% CI = -0.97 to -0.14; I²= 0%; p < .001), whereas yoga exercises did not demonstrate a significant effect.CONCLUSIONS: In this study, core-based exercises positively improved proprioception in patients with neurological disorders, and were particularly effective in stroke patients. Among various types of core exercises, only core stability exercises had a positive effect on proprioception in patients with neurological disorders.
Isokinetic Ankle Inversion and Eversion Muscle Strength in Korean Men’s Professional Basketball Players
Authors: Song Mun-Ku
Published: June 2024

PURPOSE: In this study, the isokinetic strength of ankle inversion and eversion in Korean professional basketball players (KBL) was assessed, distinguishing between their dominant and non-dominant legs, as well as across different positions.METHODS: A meticulously designed study was conducted involving 25 KBL players (12 guards, 11 forwards, and 2 centers) with an average age of 27.8 ± 5.3 years. The CSMI Norm isokinetic dynamometer, a highly accurate instrument, was used to measure bilateral isokinetic concentric strength at 60°·s-¹ and 150°·s-¹. The study measured peak torque (Nm), body mass normalized peak torque (Nm·kg-¹), bilateral strength asymmetry, and the eversion-to-inversion strength ratio in both dominant and non-dominant legs.RESULTS: Peak torques, normalized peak torques, and eversion-to-inversion strength ratios were not significantly different between the dominant and non-dominant legs at the two angular speeds. There was also less than a 10% asymmetry in strength between the two legs. However, a position-specific analysis revealed that guards had a significantly higher normalized peak torque (0.35 vs. 0.30 Nm·kg-1, p = .048) for ankle inversion of the dominant leg at 150°·s-¹ compared to forwards.CONCLUSIONS: The results suggest that healthy KBL players exhibit symmetrical ankle inversion and eversion muscle strength between their dominant and non-dominant sides, with possible positional differences in strength. These findings serve as a reference for the assessment of inversion and eversion strength in basketball players.
Prolonged Hypoxic Exposure Impairs Endothelial Functions: Possible Mechanism of HIF-1α Signaling
Authors: Hong Junyoung , Shin Junchul
Published: June 2024

PURPOSE: Hypoxic training enhances oxygen availability by elevating hemoglobin, red blood cells, and capillaries. hypoxia-inducible factor (HIF) stabilization under hypoxic conditions triggers glycolysis, erythropoiesis, and angiogenesis. However, prolonged hypoxic exposure causes endothelial cell dysfunction, contributing to cardiovascular diseases. Furthermore, endothelial mitochondria play a crucial role in maintaining endothelial cell homeostasis through the processes of biogenesis, signaling cellular response, mitochondrial dynamics, and calcium homeostasis. However, the molecular response of endothelial mitochondria has not been fully elucidated. Therefore, this study aimed to investigate the endothelial mitochondria functions and morphological change in response to hypoxia.METHODS: Cobalt chloride and 2% hypoxic condition were applied to HUVECs. The endothelial cell functions were assessed using BrdU-based proliferation assay and scratch wound healing assays. Mitochondrial functions were evaluated using Mitosox and MitoTracker staining for mitochondrial reactive oxygen species (mtROS) and mitochondrial morphology analysis, respectively.RESULTS: The hypoxic condition (2% of O2) significantly decreased endothelial proliferation/migration and mitochondrial function. Furthermore, CoCl2 treatment increased the mtROS levels and mitochondrial fragmentation in HUVECs. Additionally, hypoxic conditions were found to regulate the phosphorylation of eNOS, mitochondrial biogenesis, mitophagy, and cell cycle-related protein expression.CONCLUSIONS: These results suggest that the HIF-α pathway leads to endothelial dysfunction via mitochondrial dysfunction. Further mechanistic studies will be needed to elucidate the cellular and molecular mechanisms by which hypoxic-response pathways influence the health and homeostasis of endothelial cells. The findings reported herein underscore the importance of strategies for hypoxic training to prevent cardiovascular diseases.
Decidindo pela fragilidade: uma análise de argumentos contra teorias multiplicadoras sobre a individuação entre-mundos de eventos
Authors: Machado Ícaro Miguel Ibiapina
Published: June 2024

Resumo: Este artigo aborda uma questão clássica na Metafísica dos Eventos relacionada às condições em que um evento específico permanece inalterado diante de mudanças contrafactuais possíveis. Multiplicadores, os quais admitem pouca ou nenhuma variação nas categorias de propriedades para a individuação de eventos, contrastam com os unificadores, mais tolerantes a essas variações. Dois argumentos fundamentais são criticamente analisados. Primeiramente, são discutidos argumentos baseados em práticas linguísticas comuns, que sugerem falarmos comumente sobre mesmos eventos como podendo ocorrer em distintos pontos temporais. Contraexemplos demonstram a falta de confiabilidade dessas práticas, do ponto de vista da metafísica da individuação de eventos. Em segundo lugar, aborda-se o argumento de que a posição não fragilista entra em conflito com o princípio das possibilidades alternativas e a intuição de que casos com alternativas de ação muito próximas não envolvem responsabilidade moral. A análise indica que tais casos podem envolver ações numericamente distintas, sugerindo a necessidade de uma modificação no princípio das possibilidades alternativas. Conclui-se que não há razões plausíveis para rejeitar a postura fragilista, sendo possível decidir abdutivamente a favor dela.
The influence of Western culture on the Central Asian States’ and Kazakhstan’s science
Authors: Ainakulov Sanat , Tulekova Mereke , Oshanova Nurzhamal
Published: June 2024

Abstract: The relevance of the study is due to the fact that the Central Asia’s culture is of great interest for modern sociological science as an object of study of intercultural interaction and as a multifaceted, complex, controversial, and dynamic phenomenon. The topic of the influence of Western culture and philosophy on the science of more Eastern regions, according to the authors, has been rather neglected. The purpose of the paper is to study the influence of Western culture on the Central Asian states and Kazakhstan’s science, including philosophical, historical and cultural direction. The comparative approach was used to study materials on the development of Western science and their distribution in the foreign countries’ cultures, as well as the analysis of these materials. As a result, a series of statements was deduced that confirms the influence of Western science on Kazakhstan’s and Central Asia’s countries’ science. It was concluded that democratic ideas, educational sentiments and revolutionary movements, in Russia, had a significant impact on Central Asia and Kazakhstan.
Philosophical values and landscape cognition of Orchid Pavilion in Zhejiang from the perspective of environmental history
Authors: Zhang Quan , Jin Xiaojun
Published: June 2024

Abstract: With the traditional society’s continuous development and the change in the water environment, the Orchid Pavilion landscape has changed several times. The cognition of the Orchid Pavilion landscape, by the literati of the past dynasties, has also been continuously sublimated due to a range of natural and societal factors. As an important historical landscape, south of the Yangtze River, Orchid Pavilion contains more historical and cultural significance than the landscape itself. From Wei and Jin Dynasties to Tang Dynasty, the beautiful water environment and cultural landscape of Orchid Pavilion aroused nationwide longing and appreciation for its beauty. However, from the Song Dynasty to the end of the Ming Dynasty, factors, such as warfare, population growth and climate change caused damage to the water environment, and the landscape of the Orchid Pavilion was not spared. Scholars had to recall the Orchid Pavilion landscape in their work due to its destruction. In the Qing Dynasty, imperial power intervened to rebuild Orchid Pavilion landscape. The literati and officials, in the south of the Yangtze River, gradually accepted the rule of the Qing regime, and the image of the Orchid Pavilion landscape was reshaped. Since the Republic of China, the adherents of the late Qing Dynasty have used Orchid Pavilion and its ritual activities to reinforce their sense of identity through new forms of media. The preface to the Orchid Pavilion is a collection of events, articles and calligraphy, which surpasses the general value for viewing. Although calligraphy achieves its ultimate significance, the influence of events and articles is the condition for it to enter the classical world, and the legendary appearance and the support of imperial power are the important aids to its spread.
Characterization of bovine mesenchymal stromal cells from visceral adipose tissue collected post-mortem
Authors: Yaneselli Kevin , Salaverria Eugenia Iglesias , Ávila Gimena , Benavides Uruguaysito , Vázquez Noelia , Algorta Agustina
Published: June 2024

ABSTRACT: Adipose tissue can be a source of bovine mesenchymal stromal/stem cells (MSCs). However, most studies do not incorporate post-mortem collection or in vitro differentiation of these cells from bovine fat and other sources into three mesodermal lineages. This study characterized and cryopreserved bovine adipose tissue-derived MSCs (AD-MSCs) collected post-mortem. Cells were isolated from cattle (Bos taurus) and cultured under standard conditions for ex vivo expansion and cryopreservation. Cell growth kinetics was determined by cell doubling time after consecutive cellular passages. Clonogenic capacity was determined using the colony-forming unit fibroblast (CFU-F) assay. The trilineage differentiation assay was performed to determine its in vitro multipotency. The in vitro proliferation and clonogenic capacity of bovine AD-MSCs was maintained across successive passages (P2-P6). Greater clonogenic capacity was found in fresh than post-cryopreservation cells. Cells showed multipotential capacity in adipose, cartilage and bone lineages. In conclusion, no changes were observed in the growth kinetics and colony-forming capacity of the successive passages evaluated. Clonogenic capacity was higher in fresh than post-cryopreserved cells.
Ions levels in the gastrointestinal tract content of silver catfish Rhamdia quelen (Siluriformes: Heptapteridae) are related to the reproduction period
Authors: Becker Alexssandro Geferson , Baldisserotto Bernardo , Copatti Carlos Eduardo
Published: June 2024

ABSTRACT: The current study tested the hypothesis that an increase in the ionic levels (Na+, Cl-, Ca2+, Mg2+, and K+) in the gastrointestinal tract (GIT), and hepatosomatic index (HSI), gonadosomatic index (GSI), and Fulton’s condition factor (FCF) are associated with the reproduction period of silver catfish (Rhamdia quelen). So, we verified ionic levels of the fluid phase of the different portions of the GIT content, HSI, GSI, and FCF of silver catfish in different seasons in a dam in southern Brazil. The highest Na+ and Cl- levels in GIT were found in spring. The stomach’s Na+ and Cl- values were lower than the other segments. The K+ and Ca2+ levels in GIT were higher in winter, except in the stomach, where the values increased in summer. The highest K+ levels were reported in the anterior intestine. The highest Ca2+ levels in winter and spring were reported in the anterior and mid-intestines. In summer, the Mg2+ levels in the intestine were lower. The values of GSI and FCF were higher in winter and spring, and those of HSI were higher in winter. In conclusion, ions in the GIT and HSI, GSI, and FCF were higher in the reproduction period (winter for spring).
La hegemonía de la infraestructura. Ambiente, desarrollo y las grietas del consenso en la Provincia de Córdoba, Argentina
Authors: Koberwein Adrián
Published: June 2024

Resumen Nos basamos en la teoría gramsciana de la hegemonía y en la teoría del valor de David Graeber para explorar las posibilidades de una contra-hegemonía al manejo ambiental del agua en la provincia argentina de Córdoba. Se analizan conflictos entre dos posiciones contrarias en la zona de Sierras Chicas. Por un lado, las propuestas hegemónicas de soluciones por medio de grandes y medianas obras de infraestructura para lidiar con las sequías e inundaciones en relación al desarrollo; por otro, a propuestas que ponderan soluciones adecuadas a las formas bio-físicas del ciclo hidrológico de un ambiente serrano.
EFEITO DE CULTIVARES DE ALGODOEIRO (GOSSYPIUM HIRSUTUM L.) SOBRE ALGUNS ASPECTOS BIOLÓGICOS DAS FASES IMATURAS DE CHRYSOPERLA EXTERNA (HAGEN, 1861) (NEUROPTERA: CHRYSOPIDAE)
Authors: Pessoa L.G.A. , Souza B. , Silva M.G. , Carvalho C.F.
Published: June 2024

RESUMO Avaliaram-se os efeitos das cultivares de algodoeiro Auburn SM 310, JPM 781-88-3, Allen e IPEACO-SL 22-61131 sobre alguns aspectos biológicos das fases imaturas de Chrysoperla externa. Os experimentos foram conduzidos em sala climatizada a 25 ± 2º C, 60 ± 10% UR e fotofase de 12 horas, em delineamento inteiramente casualizado. Larvas recém-eclodidas foram colocadas em placas de Petri contendo discos foliares de 5 cm de diâmetro das quatro cultivares, sendo alimentadas com ninfas de terceiro e quarto ínstares de Aphis gossypii. Dessa forma, pôde-se verificar o efeito direto das cultivares sobre a biologia do predador. De maneira geral, apenas a fase larval foi afetada pelas cultivares, observando-se que a Auburn SM 310 interferiu de forma negativa, promovendo um alongamento na duração dessa fase e uma redução na viabilidade do primeiro ínstar. Também se pode observar que os tricomas existentes nas folhas das cultivares não interferiram no desenvolvimento das fases imaturas de C. externa e, dessa forma, os efeitos negativos proporcionados pela cultivar Auburn SM 310 podem estar relacionados a algum fator de natureza química.
FLUTUAÇÃO POPULACIONAL DE MOSCAS-DAS-FRUTAS DO GÊNERO ANASTREPHA SCHINER, 1868 (DIPTERA, TEPHRITIDAE) NO CAMPUS "LUIZ DE QUEIROZ", PIRACICABA, SÃO PAULO
Authors: Uramoto K. , Walder J.M.M. , Zucchi R.A.
Published: June 2024

RESUMO Este trabalho foi conduzido no Campus "Luiz de Queiroz" da Universidade de São Paulo, no Município de Piracicaba, Estado de São Paulo. Teve como objetivo estudar as flutuações populacionais das espécies mais abundantes de moscas-das-frutas (Anastrepha fraterculus, A. obliqua, A. pseudoparallela e A. bistrigata). Um aumento no nível populacional das espécies de Anastrepha Schiner, 1868 ocorreu de agosto a novembro, com acme em setembro. A flutuação populacional de A. fraterculus apresentou o mesmo padrão observado para o total de fêmeas capturadas, em conseqüência de sua alta densidade populacional. Provavelmente, a disponibilidade de frutos hospedeiros seja determinante na variação do tamanho das populações das espécies mais abundantes de Anastrepha.