bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between duration of physical exercise and menstrual cycle female athletes in East Java Sports High School
Authors: Romadona Paula Eka
Published: November 2021

Exercise can be a supporting factor or inhibitor of reproductive health related to menstruation. East Java Sports High School is a particular school for athletes who have more intensive physical training than other public schools. This research was conducted to determine whether there is a significant relationship between the duration of physical exercise and the menstrual cycle in female athletes at East Java Sports High School. The method of this research is quantitative, with a sample of 60 respondents from 14 sports. Data is processed and calculated with Microsoft Excel and SPSS version 21, the statistical test used chi-square test. The calculation results obtained were 0.002 <0.05, so there is a significant relationship between the duration of physical exercise and the athlete's menstrual cycle at East Java Sports High School. That can be caused by excessive use of energy when practicing so that the energy in the body is out of balance which results in decreased pulsatile GnRH, which can affect FSH. In addition, the results of calculations on the variable menstrual disorders in the form of physical disorders during menstruation obtained results 0.565 >0.05, so there is no significant relationship between the duration of physical exercise with menstrual disorders in athletes at East Java Sports High School.
Gamal (Gliricidia Sepium) Leaf Extract Increase Mortality of Fasciola gigantica In Vitro
Authors: Zulianti Brillia , Hamid Iwan Sahrial , Yudhana Aditya , Rahmahani Jola , Yunita Maya Nurwartanti , Wibawati Prima Ayu
Published: November 2021

Fasciolosis is a disease caused by infection with liver fluke (Fasciola sp). Fasciolosis is a parasitic disease that is important because it can cause high economic losses. The aim of this study was to investigate the effect of gamal (Gliricidia sepium) leaf extract against mortality of Fasciola gigantica in vitro study. In present study was completely randomized design with six treatments and each treatment were divided into four replications. A total of 240 specimens from infected cattles were used in this study. The observation and recording of F. gigantica mortality in all treatments with concentrations of gamal leaf extract P1 (1%), P2 (2%), P3 (3), P4 (4%), K + (Nitroxynil 2%) and K- (physiological NaCl) rate was done in 30, 60, 90, 120, 150, 180, 210 and 240 minutes, respectively. The mortality of F. gigantica was confirmed if there was no movement when triggered by anatomy tweezers then dipped in slightly warm water (50 15â„ƒ"> ). The data was analyzed using ANAVA Faktorial and continued with Duncan Multiple Range Test. The results of this study were shown the lowest and the highest mortality rate recorded at minutes 30 and 240 respectively. Moreover, the mean of mortality rate were peaked in nitroxynil (K+) and 1% gamal leaf extract treatment, while the lowest mean of mortality rate occurs in NaCl (K-) treatment. Present study conclude that gamal leaf extract has anthelmintic effect on the mortality rate of Fasciola gigantica. Gamal leaf extract with 1% concentration was claimed to be the most effective.
Necrosis Description of Mice Liver Induced with Monosodium Glutamate and Methanol Robusta Coffee Bean Extract (Coffea canephora)
Authors: Al-Zuhroh Tisya Yumn , Santoso Kuncoro Puguh , Yunita Maya Nurwartanti , Hidajati Nove , Praja Ratih Novita
Published: November 2021

This study aimed to analyze the effect of methanol robusta coffee bean extract (Coffea canephora) on liver histopathological description in mice induced with monosodium glutamate (MSG). This study was used 20 male mice for 5 treatment groups: K + (MSG 0.12 mg and Vitamin C 6 mg), K- (MSG 0.12 mg and CMC Na 0.1 ml), P1 (MSG 0.12 mg and RCE 0.1 mg), P2 (MSG 0.12 mg and RCE 0.2 mg), and P3 (MSG 0.12 mg and RCE 0.4 mg) per orally for 42 days. Liver histological scores were analyzed using Kruskal Wallis test. The results of Kruskal Wallis test scored p=0,391 which indicates that the data is not significant (p>0.05). In the control and treatment groups there were no significant. In conclusion, the giving methanol robusta coffee bean extract did not show a decrease in hepatosite damage that was different from the negative control treatment group.
TNF-α plus IL-1β Induces Opposite Regulation of Hemichannels and Gap Junctions in Mesangial Cells Through a RhoA/ROCK-dependent Pathway
Authors: Lucero Claudia M. , León Marcelo A. , Fernández Paola , Orellana Juan A. , Velarde Victoria , Sáez Juan C , Gómez Gonzalo I
Published: November 2021

Connexin 43 (Cx43) is expressed in kidneys and constitutes a feedforward mechanism leading to inflammation in other tissues where they form hemichannels and gap junction channels. However, the possible functional relationship between these membrane channels and their role in damaged renal cells remains unknown. Here, analyses of ethidium uptake and thiobarbituric acid reactive species revealed that TNF-α plus IL-1β increase Cx43 hemichannel activity and oxidative stress in MES-13 cells, a cell line derived from mesangial cells. The latter also was accompanied by a reduction in gap junctional communication, whereas western blotting analysis showed a progressive increase of phosphorylated MYPT (a substrate of RhoA/ROCK) and Cx43 upon TNF-α/IL-1β treatment. Additionally, inhibition of RhoA/ROCK strongly diminished the TNF-α/IL-1β-induced activation of Cx43 hemichannels and reduction in gap junctional coupling. We propose that activation of Cx43 hemichannels and inhibition of cell coupling during pro-inflammatory conditions could contribute to oxidative stress and damage of mesangial cells via the RhoA/ROCK pathway.
Развитие математических моделей эпидемии с учетом влияния изоляции особей в популяции
Authors: Аманбаев Тулеген Рахманович , Amanbaev Tulegen Rakhmanovich , Энтони С Д , Antony S J
Published: November 2021

Анализируется влияние изоляции особей популяции на динамику эпидемии. На основе SIR модели построена SIRDi модель, где учитывается изоляция особей, а также наличие умерших больных, которую уместно использовать в случаях обширного распространения инфекции, когда число инфицированных сравнимо с числом уязвимых (т.е. тех, кто может быть инфицирован - Susceptible). Предлагаются упрощенные IRD и IRDi модели для изучения распространения инфекционной болезни на начальном этапе эпидемии (или для случая, когда скорость распространения инфекции не велика). Обнаружено, что существует пороговое значение коэффициента (доли) изоляции, которое разграничивает качественно разное поведение эпидемических показателей популяционной системы. Приведено сравнение между разными моделями. Показано, что упрощенная (IRDi) и более сложная (SIRDi) модели на начальном этапе эпидемии дают приблизительно одинаковые результаты.
Численное исследование влияния преграды на обтекание вертикально-осевой ветротурбины
Authors: Бондарев Александр Евгеньевич , Bondarev Aleksandr Evgen'evich , Бондаренко Александр Викторович , Bondarenko Alexander Viktorovich , Галактионов Владимир Александрович , Galaktionov Vladimir Aleksandrovich , Жуков Виктор Тимофеевич , Zhukov Victor Timofeevich , Мануковский Константин Викторович , Manukovskiy Konstantin Viktorovich , Новикова Наталия Дмитриевна , Novikova Nataliya Dmitrievna , Феодоритова Ольга Борисовна , Feodoritova Olga Borisovna
Published: November 2021

Представлены результаты численного моделирования вертикально-осевой ветротурбины на основе решения трехмерных осредненных по Рейнольдсу уравнений Навье--Стокса с моделью турбулентности Спаларта--Аллмареса. Для ветротурбины геликоидного типа с тремя спирально закрученными лопастями приведены результаты параметрических расчетов вязкого сжимаемого обтекания в условиях, моделирующих городскую инфраструктуру.
Reporting on Qualitative Components of A Research Project
Authors: English Lyn
Published: November 2021

In this brief commentary, I first overview the strengths and weaknesses of qualitative research in education and also briefly consider mixed methods. I then offer a few suggestions for reporting on particular methodological components and the results of qualitative research. I do not address the reporting on other significant components such as the literature review and theoretical framework, given that these aspects are generic to both qualitative and quantitative research. The points I make are brief and are by no means exhaustive. Nevertheless, it is hoped that they offer some guidance for authors in education who adopt primarily qualitative methods. 
Pelatihan Manajemen Pakan untuk Meningkatkan Efisiensi Produksi Peternakan Sapi Potong Rakyat
Authors: Ratriyanto Adi , Hadi Rendi Fathoni , Widyawati Susi Dwi
Published: November 2021

Pakan merupakan salah satu faktor penentu keberhasilan dalam usaha ternak sapi potong. Pakan yang diberikan harus memenuhi kuantitas dan kualitas sesuai dengan kebutuhan ternak. Oleh karena itu diperlukan manajemen pakan yang baik, meliputi aspek pemilihan, penyimpanan, pengolahan dan pengawetan, serta metode pemberian pakan kepada ternak. Kegiatan pengabdian ini bertujuan untuk memberikan pelatihan manajemen pakan bagi peternak sapi potong di Desa Pelemrejo, Kecamatan Andong, Kabupaten Boyolali. Seperti halnya wilayah lain di Boyolali, sapi potong dipelihara sebagai salah satu bagian dari sistem pertanian yang berfungsi sebagai tabungan, penghasil kotoran maupun untuk tenaga kerja. Beberapa permasalahan dalam manajemen pakan yang teridentifkasi adalah peternak tidak mengetahui kualitas masing-masing bahan pakan dan pemberian pakan tidak terukur sehingga terjadi pemborosan bahan pakan. Kegiatan ini dilakukan dengan memberikan penyuluhan dan pelatihan manajemen pakan bagi peternak sapi potong, seperti pengenalan kualitas pakan, pengolahan dan penyimpanan pakan, serat metode pemberian pakan. Diakhir program pengabdian, peternak mampu melakukan manajemen pakan ternak sapi secara baik untuk menghasilkan pertumbuhan ternak dan keuntungan yang optimal.
Penerapan Teknologi Proses Produksi Untuk Meningkatkan Kapasitas Dan Kualitas Kecap Manis UKM Bumi Makmur Sejahtera
Authors: Fauza Gusti , Sukanto Heru , Sugiarto Catur , Hadi Syamsul , Astirin Okid Parama , Nurcahyo Wisnu , Prasetyo Ari
Published: November 2021

Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan tidak hanya kapasitas namun juga kualitas produk kecap manis kecap manis Bumi Makmur Sejahtera (BMS) khas Wonogori yang terdapat di Desa Bulusari, Kecamatan Bulusulur, Wonogiri Jawa Tengah. Dari observasi lapangan ditemukan beberapa permasalahan, yaitu waktu siklus produksi per batch produk yang masih tinggi dan proses produksi yang tidak efisien. Hal ini berdampak terhadao terbatasnya kapasitas produksi UKM. Beberapa proses yang memakan waktu lama adalah proses pemasakan (9 jam) dan pengemasan (12 jam). Permasalahan berikutnya terkait mutu dan keamanan pangan dimana wajan pemasakan yang bersentuhan langsung dengan produk terbuat dari semen (bahan yang bisa mengelupas). Kondisi ini tidak sesuai dengan konsep cara produksi pangan yang baik (CPPB) untuk industri rumah tangga. Oleh sebab pada kegiatan pengabdian ini akan diaplikasikan teknologi proses produksi yang tidak hanya meningkatkan kapasitas namun juga kualitas dan keamanan produk. Tahapan kegiatan yang dilakukan adalah: a) inisiasi dan sosialisasi program, b) pelaksanaan program, c) monitoring dan evaluasi program. Aplikasi teknologi yang diusulkan adalah sebuah  Introduksi lini produksi dengan system pengadukan otomatis dan pengemasan yag lebih efisien. Penerapan teknologi ini diharapkan dapat meningkatkan kapasitas dan kualitas produk kecap. Kemudian penggunaan bahan untuk alat yang terbuat dari stainless steel, merupakan salah satu solusi untuk menurunkan cemaran fisik. Dengan lini produksi baru ini, waktu produksi lebih pendek sehingga kapasitas meningkat signifikan. Disamping itu kualitas akan lebih baik karena dengan pengadukan otomatis adonan akan lebih homogen, serta keamanan pangan juga akan meningkat karena peralatan terbuat dari bahan yang aman untuk pengolahan produk pangan.
PENGEMBANGAN MATERI GO GREEN BAGI SISWA SMA DENGAN PENDEKATAN ACTIVE LEARNING (Pilot Project pada SMA IT Nur Hidayah Sukoharjo)
Authors: Purnomowati Nasyiah Hasanah , Asrihapsari Andi
Published: November 2021

Global warming and climate change issues and the impacts become worse recently. This condition needs real actions to maintain sustainable living being. One thing that we can do is developing go green lifestyle  for teenagers . It is important because they are  agent of future change.

This project aims to build go green mindset for Senior High School students and encourage them to implement their ideas  become real actions. A series of activities were designed by using active learning approach so the students have active roles in each activity. Firstly, we organise a go green poster competition. Secondly, we installed two  hidroponic sets to make the school greener. The winner of the poster competition became green school ambassadors who have responsibilty to maintain  hydroponic installation. They also have to do green campaign around their communities.

 
INTRODUKSI TANAMAN TEH DAN APEL INDIA DI DESA WISATA SAMIRAN KECAMATAN SELO KABUPATEN BOYOLALI PROPINSI JAWA TENGAH
Authors: Suyana Jaka , Sukaya Sukaya
Published: November 2021

Desa Wisata Samiran berada di Kecamatan Selo Kabupaten Boyolali, mempunyai luas 663,329 ha dengan elevasi 1.400-2.550 m dpl, serta jenis tanah Andosol (lereng Merbabu) dan Regosol (lereng Merapi). Secara agroklimat cocok untuk pengembangan agrowisata  tanaman perkebunan (teh dan kopi Arabika), tanaman buah (tledung, apel, dan jeruk), tanaman hias, serta sayuran.  Kegiatan PKM (Program Kemitraan Masyarakat) ini bertujuan untuk introduksi tanaman Teh (Camellia Sinensis L.O. Kuntze) dan tanaman Apel India (Ziziphus Muritania) pada kelompok tani di Desa Wisata Samiran. Tanaman Teh Varietas Gambung-7 diintroduksikan sebagai  tanaman pagar (hedgerows) dikiri-kanan lorong jalan desa, sedangkan tanaman Apel India  sebagai tanaman buah di pekarangan petani. Mitra yang dipilih yaitu  Kelompok Tani Taruna Subur (Dukuh Samiran, Desa Samiran, Kec. Selo) dan Agrowisata Tretes Taman Tani (Dukuh Tretes, Desa Samiran, Kec. Selo). Metode yang digunakan meliputi : (a) penyuluhan dan sosialisasi program PKM; (b) pemberian bibit dan penanaman Teh sebagai tanaman pagar di lorong kiri-kanan jalan desa; (c) pemberian bibit dan penanaman Apel India sebagai tanaman buah di pekarangan rumah; serta (d) pemberian bibit Teh dan Apel India di Agrowisata Tretes Taman Tani. Seluruh anggota kelompok tani dilibatkan dari kegiatan penyuluhan, pemberian bibit, penyiapan lahan dan penanaman, serta perawatan tanaman. Target dari PKM ini untuk meningkatkan atensi akademisi Riset Grup Pengelolaan DAS dan Agroekosistem Fakultas Pertanian UNS, bersama kelompok tani  untuk ikut berpartisipasi di dalam pengembangan Desa Wisata Samiran yang lebih asri dan sejahtera.
Pengaruh atribut tata kelola dan karakteristik perusahaan terhadap kebijakan dividen pada perusahaan di BEI
Authors: Serly Serly , Susanti Mery
Published: November 2021

The dividend was a kind of return from portfolio investment. Firms in making dividend payment decisions are influenced by several motives. The main topic of the research was to determine the impact of corporate governance and firm characteristics on the decision of dividend policy. In here, corporate governance was focused on board characteristics consisting of board size, independent director, board meeting frequency, woman director, and audit committee size. While the firm characteristics were measured by size, profitability (ROA), and leverage. The research used companies data collected from Indonesia Stock Exchange. Companies data must available from the period 2015-2019 and resulted in 2.175 sample data. The research used the panel regression method. The result of the research proved that board size and profitability (ROA) significantly positively influenced the dividend policy. Board meeting frequency showed a positive effect on dividend per share, but no effect on dividend per asset. Otherwise, women directors and leverage reflected a significant negative effect with dividend per assets, but an insignificant effect on dividend per share. On the other hand, firm size, independent director, and audit committee size did not have any significant impact on dividend policy decisions.
Manajemen program Kredit Usaha Rakyat Super Mikro masa pandemi Covid-19
Authors: Kusuma Anton Adi Suryo , Rohmah Wafrotur , Fathoni Achmad , Muhibbin Ahmad , Hidayati Yulia Maftuhah
Published: November 2021

This study aims to describe the planning, organization, implementation, and supervision of the Super Micro People's Business Credit (KUR) program during the covid-19 pandemic in BRI Unit Made, Sragen. The research method used in this research is qualitative. The research subjects were 20 people, consisting of customers, BRI managers, BRI unit heads, and BRI officers. Data collection techniques are through interviews, observations, and documents. The data validity technique used is source and technique triangulation. The results of this study reveal that in the planning stage of the Super Micro KUR program, it aims to help accelerate economic recovery during the COVID-19 pandemic by providing soft loans for entrepreneurship community capital. The strategy used is through massive socialization both online and offline. At the organizing stage in the form of division of tasks in accordance with their respective job descriptions and ensuring officers carry out their main duties and functions. The implementation phase begins with intensive socialization and marketing so that the public knows the benefits of this program. The supervision phase is carried out through daily monitoring by the unit head and BRI micro marketing manager so that credit distribution can be maximized and on target.
Hypothyroidism is Strongly Correlated with Mean Platelet Volume and Red Cell Distribution Width
Authors:   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Bilgin Satilmis , Tel Burcin Meryem Atak ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Kahveci Gizem ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Duman Tuba Taslamacioglu ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Kurtkulagi Ozge ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Yurum Semanur ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Erturk Asli ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Balci Buse ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Aktas Gulali ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Published: November 2021

Abstract: Objective: Hypothyroidism is characterized with insufficient production and release of thyroid hormones, and cause a variety symptoms including cold intolerance, constipation, deceleration in movement, and hair loss. It is associated with increased inflammatory burden. Therefore, we aimed to observe red cell distribution width (RDW) and mean platelet volume (MPV) levels, novel predictors of inflammation, in patients with hypothyroidism and to compare to those in healthy subjects. Materials and Methods: The subjects with hypothyroidism that show up in internal medicine outpatient clinics of Abant Izzet Baysal University Hospital between January 2020 and January 2021 were enrolled to the retrospective study. Healthy volunteers were enrolled as control subjects. MPV and RDW of the study groups were compared. Results: The median RDW level of hypothyroid and control groups were 13.3 (10-20.7) % and 15.3 (11.8-21.3) %, respectively (p<0.001). The median MPV level of hypothyroid and control groups were 10.2 (6.4-12.4) fL and 8.1 (5.4-11.5) fL, respectively (p<0.001). MPV levels greater than 9.47 fL have 80% sensitivity and 72% specificity in predicting hypothyroidism (AUC: 0.66 [95% CI: 0.58-0.74]; p<0.001). RDW levels greater than 13.4% have 80% sensitivity and 50% specificity in predicting hypothyroidism (AUC: 0.67 [0.82 [95% CI: 0.59-0.75]; p<0.001). Conclusion: We suggest that elevated MPV and reduced RDW levels should alert physicians for hypothyroidism in otherwise healthy subjects. Keywords: Hypothyroidism, Red cell distribution width, Mean platelet volume, Inflammation, Thyroid hormones, Predictor, Retrospective study.
Severe Pancytopenia and Stomatitis Case due to the Treatment with High Dose Methotrexate
Authors:   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Tel Burcin Meryem Atak , Bilgin Satilmis ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Kurtkulagi Ozge ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Kahveci Gizem ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Aktas Recep ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Kurt Kamile ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Duman Tuba Taslamacioglu ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey., Aktas Gulali ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Published: November 2021

Abstract: Objective: Methotrexate is used to suppress inflammation in many rheumatologic conditions. Here we present an elderly patient who developed serious side effects due to methotrexate. A 78 year old male admitted to emergency department with oral mucosal bleeding, skin rash, decrease in oral nutrition intake and weakness. He had been using 5 milligrams of methotrexate as 2 tablets twice a day for 10 days, after he was diagnosed with psoriatic arthritis 15 days ago. A diagnosis of methotrexate intoxication established with history, physical examination and laboratory analysis, which revealed pancytopenia. His signs and symptoms, as well as pancytopenia were recovered on 6th day of the hospitalization. He had been treated with folinic acid and filgrastim along with supportive care. Although methotrexate treatment and toxicity is well established it is still a clinical challenge that all clinicians must be aware of. In conclusion, methotrexate intoxication is a clinical entity that can lead to serious clinical consequences, and it is essential to diagnose and initiate appropriate treatment without delay to prevent morbidity and mortality. Keywords: Methotrexate toxicity, Pancytopenia, Treatment, Folinic acid, Filgrastim, Inflammation, Psoriatic arthritis.
Analysis of The Effect of Remittance on Economic Growth in Developing Countries East Asia and Pacific Region
Authors: Romadona Firdan Belado , Wibowo Wisnu , Rahman Hairul
Published: November 2021

This study determine how remittances affect economic growth in the developingcountries of East Asia and the Pacific region. The type of data in this study issecondary data with the form of panel data. This research was conducted in the period 2000-2019 in 11 developing countries in East Asia and the Pacific region. This study used Random Effect Model estimation to determine the influence ofindependent variables, namely GDP per capita with dependent variables, namelyremittances, working-age population, FDI, and trade openness. The result showsthat variable remittances and working-age populations positively and significantlyimpact economic growth in developing countries in East Asia and the Pacific region.The estimated results for FDI variables negatively and significantly affect developingcountries economic growth in East Asia and the Pacific region. Estimates for tradeopenness variables have no significant effect on developing countries economicgrowth in East Asia and the Pacific region.
ANALISIS PENGARUH BELANJA PEGAWAI, BELANJA BARANG DAN BELANJA MODAL TERHADAP REALISASI PENERIMAAN PAJAK DI INDONESIA
Authors: Kurniawan Tria Sandi , Irmawati Dyah Reni
Published: November 2021

This study examines the effect of the realization of government spending consisting of goods expenditure, capital expenditure and employee expenditure on tax revenue in Indonesia. In this study, we use four analytical methods that consist of  Granger Test, Partial Adjustment Model (PAM), Error Correction Model (ECM) and Vector Autoregression (VAR). The result shows that the realization of goods and employee expenditure are significant determinant of the tax revenue. Further examination shows that the shocks on goods and employee expenditure havea positive impacts toward tax revenue. However the shock effects are different on those variables. On the shock to goods expenditure, the tax revenue response will occur directly, in contrast to shock on employee expenditure that requires time lag. This study also finds that between PAM and ECM, the ECM model is more appropriate to be used to explain the effect of government spending on tax revenue in Indonesia.
STRATEGI PENGEMBANGAN AGROPOLITAN KOPI ROBUSTA BERSERTIFIKAT INDIKASI GEOGRAFIS DI KECAMATAN PUPUAN TABANAN
Authors: Laksmi Ni Made Citra , Sumantra I Ketut , Maba Wayan
Published: November 2021

The high demand for Pupuan robusta coffee was not followed by an increase in production. Robusta coffee farming has not been able to increase farmers' income, therefore the concept of agropolitan area development is needed. The purpose of this study was to formulate a strategy for developing agropolitan areas for robusta coffee in Pupuan, research time from September to November 2020. The research method uses are observation, interviews, and questionnaires. The data analysis used in this study are SWOT and QSP matrix. The results showed that the results of IFAS and EFAS data processing, the values of x = 1.13 and y = 1.24 are obtained that they are in quadrant I (Growth), so the strategy applied is the SO strategy. Based on the QSPM calculation, the highest TAS value was 6.96. The conclusion from the research results shows that in the Pupuan sub-district there is a potential for upstream and downstream Robusta coffee agribusiness. The strategy obtained in accordance with the SWOT table is the SO strategy. An alternative strategy in accordance with QSPM is to carry out an applied study of the pre-harvest and post-harvest processing technology for robusta coffee.
Outpatient COVID-19 Pneumonia In Elderly Patients In Kazakhstan
Authors: U. Essetova G. , L.R Idrissova , T.A Muminov
Published: November 2021

COVID pneumonia is difficult to manage in elderly patients over 65 years of age.The aim of the study was to determine the clinical features of the course of COVID pneumonia in a cohort of patients over 65 years old.Materials and methods: We observed patients with community-acquired pneumonia, of whom PCR positive for COVID were 33 patients, mean age 67.6 ± 12 years, men – 11, women – 22; 16 patients had no confirmed virus (COVID PCR negative), mean age 65.5 ± 8.2 years, 7 women and 9 men.Examination results: in the group of COVID patients, the disease more often proceeded according to the type of bilateral polysegmental pneumonia according to CT data, with severe monocytosis, с thrombocytosis and transient increase in creatinine, which required the appointment of intensive anticoagulant therapy. Arterial hypertension was observed in the majority of people. In the control group (PCR -), pneumonia proceeded predominantly as bronchopneumonia, saturation indices were approximately the same in both groups. COVID patients had significantly higher levels of monocytes, blood platelets, CRP, creatinine levels, including arterial hypertension was more common.Conclusion: COVID pneumonia in elderly patients proceeds as multisegmented bilateral pneumonia with moderate disseminated intravascular coagulation syndrome, which is well controlled due to complex therapy with anticoagulants and antibiotics.
Multicomponent Synthesis of 2, 4, 6-Triarylpyridine Analogues As Antibacterial And Antiurease Agents
Authors: Saleem Muhammad , Perveen Ayesha , Hussain Erum Akbar , Rehman Abdul , Khan Majid , Irshad Misbah , Imran Muhammad , Irfan Ahmad , Ali Muhammad , Niaz Shahiram , Rauf Abdur , Mubarak Mohammad S
Published: November 2021

Five new 2,4,6-triarylpyridine analogues with potential biological importance have been synthesized using the multicomponent reaction (MCR) solid support catalyst synthetic approach. This green synthesis furnished method simplicity, reduce reaction time, and excellent yield, along with an additional feature of catalyst reusability. A number of spectroscopic techniques such as 1H-NMR, IR, and mass spectrometry, confirmed structures of the newly synthesized compounds. Antibacterial and anti-urease activities of these compounds were evaluated. Results revealed that compounds 4a, 4c, 4d, and 4e exhibit significant inhibition against gram-positive bacterial pathogens. Furthermore, all synthesized compounds showed potent urease inhibitory activity with IC50 values ranging from 12.8 ± 1.04 to 23.7 ± 0.23 µM when compared with the standard inhibitor thiourea (IC50 21.0 ± 0.23 µM).In addition, the synthesized derivatives were subjected to density functional theory (DFT) calculations (DFT) to determine the energy of the molecules having biological potential.
Distributed Event-Triggered Consensus Control of Multi-Agent Systems under Denial-of-Service Jamming Attacks
Authors: Xiong Mingyue , Wang Xin , Cheng Jun
Published: November 2021

This work focuses on the consensus problem of multi-agent systems (MASs) under event-triggered control (ETC) subject to denial-of-service (DoS) jamming attacks. To reduce the cost of communication networks, a novel event-triggering mechanism (ETM) is applied to the sleeping interval to determine whether the sampled signal should be transmitted or not. Unlike periodic DoS attacks model, the DoS attacks occurrence are irregular, where attack attributes such as attack frequency and attack duration are taken into account. Moreover, compared with the fixed topological graph, the communication topologies may change due to DoS jamming attacks in this work. In view of this, based on the piecewise Lyapunov functional, sufficient conditions are derived to guarantee that consensus problem of the MASs can be solved. Finally, the effectiveness and correctness of the theoretical results are verified by a numerical example.
Primary Catheter-Directed Thrombolysis For Porto-Mesenteric Venous Thrombosis (PMVT) In Non-Cirrhotic Patients.
Authors: Chiang Chia-Ling , Liang Huei-Lung , Li Ming-Feng
Published: November 2021

Purpose: To report our technique, treatment strategy and clinical outcomes for porto-mesenteric venous thrombosis (PMVT) in non-cirrhotic patients.Methods: 16 non-cirrhotic PMVT patients (mean age: 48.6 years) with imminent intestinal ischemia were enrolled from 2004-2020. 8 patients presented thrombus extension into the peripheral mesenteric vein, close to the venous arcade. Transhepatic catheter-directed thrombolysis (CDT) was performed by urokinase infusion (60,000-30,000 IU/hour concomitant with heparin 300-400 IU/hour), catheter aspiration and/or balloon dilation/stent placement. Additional intra-arterial mesenteric infusion of urokinase (30,000 IU/hour) was given in patients with the peripheral mesenteric venules involved. Transjugular intrahepatic porto-systemic shunt (TIPS) was created in patients with poor recanalization of the intrahepatic portal flow (PV). Results: The transhepatic route was adopted in all patients, with adjunct indirect mesenteric arterial thrombolytic infusion in 8 patients. A total of up to 20.4 million IU urokinase was infused for 1-30 days’ treatment duration. TIPS was created in 3 patients with recanalization failure of the intrahepatic PV. Technical success was achieved in 100% of patients with complete recanalization of 80% and partial recanalization of 20%. No major procedure-related complications were encountered. The 30-day mortality rate was 6.7%. The overall 1- and 2-year primary and secondary patency were both 74.0% and 84.6% respectively. Conclusions: CDT can be performed as a primary salvage treatment once the diagnosis is made. CDT via the transhepatic route with tailored thrombolytic regimen is safe and effective for both acute and chronic PMVT . TIPS creation can be preserved in non-cirrhotic PMVT patients if intrahepatic PV recanalization fails.
Mad7: An IP Friendly CRISPR Enzyme
Authors: Rojek Johan , Basavaraju Yogesh , Nallapareddy Saranya , Baumgartner Roland Franz , Schoffelen Sanne , Pedersen Lasse Ebdrup
Published: November 2021

Mad7 is a CRISPR enzyme, similar to Cas9 and Cas12a, which is of great interest to industry and academia due to its permissive licensing agreement, which states that everyone is free to use it but not distribute it commercially. This paper demonstrates that Mad7 genome editing works in CHO cells and provides the CHO engineering community with the computational tools needed to generate Mad7 compatible gRNAs against the CHO genome.
Preparation and Comparative Study of Aerogels Based on Cellulose Nanocrystals and Nanofibers from Eucalyptus Pulp
Authors: Zhu Wenkai , Zhang Yang , Wang Xiaoyu , Wu Yan , Han Minsu , You Jungmok , Jia Chong , Kim Jeonghun
Published: November 2021

Nanocellulose-based materials have attracted significant attention because of their attractive advantages. Particularly, aerogel, a porous nanocellulose material, have been used in diverse applications owing to their unique properties. In this study, short rod-like cellulose nanocrystals (CNCs) and long filament-like cellulose nanofibers (CNFs) were isolated from a eucalyptus pulp source using acidolysis and oxidation/mechanical methods, respectively. Subsequently, two different aerogels were prepared from the CNCs and CNFs using the sol-gel method and their properties were compared. The morphology, chemical structure, chemical composition, shrinkage rate, internal structure, thermal degradation, biophysical properties, and mechanical properties of the as-prepared aerogels were compared. Furthermore, the shrinkage of the CNC and CNF aerogels was effectively controlled using a supercritical CO2 drying process. Additionally, three decomposition regions were observed in the thermogravimetric analysis curves of the aerogels; however, the CNF aerogels exhibited enhanced thermal stability than the CNC aerogels. Further, the CNC and CNF aerogels exhibited a mesoporous structure, and the compressive strength of the CNC and CNF aerogels under 85% strain was 269.5 and 299.5 KPa, respectively. This study provides fundamental knowledge on the fabrication of CNCs, CNFs, and corresponding aerogels from lignocellulosic biomass, and their characteristics.
Association of microRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy to Public Data Analysis and in Vitro Investigation
Authors: Pathak Surajit , Meng Wen-Jian , Sriram Sushmitha , Jangamreddy Jaganmohan Reddy , Banerjee Antara , Jothimani Ganesan , Adell Gunnar , Zhang Xueli , Zhang Alexander Sun , Zhang Hong , Sun Xiao-Feng
Published: November 2021

Purpose: Radiotherapy (RT) is a standard adjuvant therapy in progressive rectal cancer patients, but many patients are resistant to RT, leading to poor prognosis. Our study identified microRNA-652 (miR-652) value on RT response and outcome in rectal cancer patients.Methods: miR-652 expression was determined by RT-PCR in primary rectal cancer from 48 patients with and 53 patients without RT. The relationship of miR-652 with biological factors and prognosis were examined. The biological function of miR-652 was identified through TCGA and GEPIA database search. Two human colon cancer cell lines (HCT116 p53+/+ and p53-/-) were used for in vitro study. Results: miR-652 expression was augmented significantly in cancer than normal mucosa in non-RT patients (P=0.044). High miR-652 expression in non-RT patients was related to more apoptosis (P=0.036), ATM (P=0.010) and DNp73 expression (P=0.009). High miR-652 expression was related to worse disease-free survival of non-RT patients, independent of gender, age, tumor stage and differentiation (P=0.028; HR=7.398, 95% CI 0.217-3.786). The biological functional analysis further identified the prognostic value and potential relationship of miR-652 with the apoptosis in rectal cancer. In RT patients, miR-652 expression was notably decreased in cancers when compared to non-RT cases (P=0.047), and miR-652 expression in cancers was negatively related to WRAP53 expression (P=0.022). After miR-652 inhibition, the estimation of reactive oxygen species, caspase activity and apoptosis in HCT116 p53+/+ cells were significantly increased compared with HCT116 p53-/- cells after radiation.Conclusions Our findings suggest the potential value of miR-652 expression as a marker for the prediction of radiation response and clinical outcome in rectal cancer patients.
Multi-Objective Casting Production Scheduling Problem by a Neighborhood Structure Enhanced Discrete NSGA-II: An Application from Real-World Workshop
Authors: Tan Weihua , Yuan Xiaofang , Yang Yuhui , Wu Lianghong
Published: November 2021

Casting production scheduling problem (CPSP) has attracted increasing research attention in recent years to facilitate the profits, efficiency, and environment issues of casting industry. Casting is often characterized by the properties of intensive energy consumption and complex process routes, which motivate the in-depth investigation on construction of practical multi-objective scheduling models and development of effective algorithms. In this paper, for the first time, the multi-objective casting production scheduling problem (MOCPSP) is constructed to simultaneously minimize objectives of defective rate, makespan, and total energy consumption. Moreover, a neighborhood structure enhanced discrete NSGA-II (N-NSGA-II) is designed to better cope with the proposed MOCPSP. In the N-NSGA-II, the advantage of selection mechanism of NSGA-II is fully utilized for selecting non-dominate solution, three neighborhood structures are elaborately designed to strengthen the ability of the local search, and a novel solution generating approach is proposed to increase the diversity of solutions for global search. Finally, a real-world case is illustrated to evaluate the performance of the N-NSGA-II. Computational results show that the proposed N-NSGA-II obtains a wider range of non-dominated solutions with better quality compared to other well-known multi-objective algorithms.
Infantil Hemangioma and Optimum Dose of Propranolol Treatment: A Retrospective Tertiary-Center Study
Authors: Cakmak Hatice Mine , Kartal Omer
Published: November 2021

Background/Objectives: Propranolol is the mainstay treatment of infantile hemangioma, and the optimal dose is unclear. Few studies are comparing the efficacy of propranolol dose of 2 vs.3 mg/kg/day. We compared the efficacy between these two doses and propranolol groups with no treatment group. Methods: One hundred eight patients with infantile hemangioma (15 days-27 months of age) were examined. The patients with high-risk features and/or a score of >6 points are given propranolol with a final dose of 2 or 3 mg/kg/day according to tolerance for 6-12 months. The resolutions rates for propranolol vs. placebo and propranolol 2 mg/kg/day vs. 3 mg/kg/day are compared. Results: The demographic and clinical features of the groups ( the non-treatment, propranolol 2 mg/kg/day group, propranolol 3 mg/kg/day group) are similar. Propranolol is significantly efficent in infantil hemangioma treatment (p<0.001). The resolution rates are not statistically different between 2 mg/kg/day propranolol group vs 3 mg/kg/day propranolol group at the sixth (68,59 ± 28,95 vs 73,44 ± 32,54)(p=0,673) and twelfth month (p=0,673) (89,08 ± 46,58 vs 91,13 ± 37,46 respectively )of follow up. A milld (n=3)(4%) adverse event was reported with no need for cessation.Conclusions: Propranolol is a safe drug for treating infantile hemangioma with an ideal dose of 2 mg/kg/day rather than 3 mg/kg/day.
Analysis of Automatically Extracted Hallux Valgus Angles Using Markerless 3D Foot Scans From North America, Europe and Asia
Authors: Jiao Yang , Džeroski Sašo , Jurca Ales
Published: November 2021

Background The forefoot is the foot most affected part by ill-fitting shoes. Footwear fitting standards have the measurements of length, width and arch length. Toe shape has not yet been used in footwear measurement. This study aims at investigating the variation in toe shape, as measured by the hallux valgus angle. Methods An automatic and reproducible hallux valgus angle measuring method using 3D foot scans with no palpation markers is proposed and applied to about half a million samples collected across North America, Europe and Asia. The measuring method is robust, it can detect the medial contour along the proximal phalanx even in extreme cases. Results The hallux valgus angle has a normal distribution with long tails on both sides in the general population. In the three regions (North America, Europe, Asia), the mean and standard deviation of this angle are 9° ± 6°, 8 ° ± 6°, 12° ± 6° for males and 11 ° ± 7°, 12 ° ± 7°, 16° ± 7° for females. Conclusions The hallux valgus angle has a broad distribution in the general population. Females have larger hallux valgus angle than males, and people from Asia have larger hallux valgus angle than people from North America and Europe.
Classify Elderly Pain Severity from Open-Source Automatically Video Clip Facial Action Units Analysis. A Study from the Integrated Pain Artificial Intelligence Network (I-PAIN) Data Repository.
Authors: Gomutbutra Patama , Kittisares Adisak , Sanguansri Atigorn , Choosri Noppon , Sawaddiruk Passakorn , Fakfum Puriwat , Lerttrakarnnon Peerasak , Saralamba Sompob
Published: November 2021

Background: It is increasingly interesting to monitor pain severity in elderly individuals by applying machine learning models. In previous studies, OpenFace© - a well-known automated facial analysis algorithm, was used to detect facial action units (FAUs) that initially need long hours of human coding. However, OpenFace© developed from the dataset that dominant young Caucasians who were illicit pain in the lab. Therefore, this study aims to evaluate the accuracy and feasibility of the model using data from OpenFace© to classify pain severity in elderly Asian patients in clinical settings.Methods: Data from 255 Thai individuals with chronic pain were collected at Chiang Mai Medical School Hospital. The phone camera recorded faces for 10 seconds at a 1-meter distance briefly after the patients provided self-rating pain severity. For those unable to self-rate, the video was recorded just after the move, which illicit pain. The trained assistant rated each video clip for the Pain Assessment in Advanced Dementia (PAINAD). The classification of pain severity was mild, moderate, or severe. OpenFace© process video clip into 18 FAUs. Five classification models were used, including logistic regression, multilayer perception, naïve Bayes, decision tree, k-nearest neighbors (KNN), and support vector machine (SVM). Results: Among the models that included only FAU described in the literature (FAUs 4, 6, 7, 9, 10, 25, 26, 27 and 45), multilayer perception yielded the highest accuracy of 50%. Among the machine learning selection features, the SVM model for FAU 1, 2, 4, 7, 9, 10, 12, 20, 25, 45, and gender yielded the best accuracy of 58%. Conclusion: Our open-source automatic video clip facial action unit analysis experiment was not robust for classifying elderly pain. Retraining facial action unit detection algorithms, enhancing frame selection strategies, and adding pain-related functions may improve the accuracy and feasibility of the model.
Evaluation the Reactivity of a Peptide-Based Monoclonal Antibody with Drug Resistant Pulsotypes of Acinetobacter Baumannii as Potential Therapeutic Approach
Authors: Yeganeh Omid , Shabani Mahdi , Pakzad Parviz , Mosaffa Nariman , Hashemi Ali
Published: November 2021

Background:

Acinetobacter baumannii is an opportunistic and antibiotic-resistant pathogen that predominantly causes nosocomial infections. There is urgent need for development nonantibiotic-based treatment strategies. We developed novel monoclonal antibody (mAb) against a peptide of conserved outer membrane protein A (OmpA) and evaluated its reactivity with different pulsotypes of A.baumannii.
Materials and Methods:

Peptide derived from A.baumannii OmpA was conjugated to keyhole limpet hemocyanin and injected into Balb/c mice. Splenocytes of immunized mice were fused with SP2/0 myeloma cells followed by selection of antibody-producing hybridoma cells. After screening of different hybridoma colonies by ELISA, one monoclone was selected as 3F10-C9 and the antibody was tested for reaction with five different Acinetobacter pulsotypes that were resistant to carbapenem antibiotics. The affinity constant was measured by ELISA. The ELISA, Western blotting, indirect immunofluorescence (IFA), and in vitro Opsonophagocytosis assays were used to evaluate the reactivity of generated mAb.
Results:

The anti-OmpA antibody reacted with the immunizing peptide and had a high affinity (around 1.94 × 10 − 9 M) for its antigen in the ELISA. Specific binding of mAb to OmpA was confirmed in Western blot. IFA assays revealed that mAb recognized specific OmpA on the pulsotypes. Opsonophagocytosis assays showed that the mAb increased bactericidal activity of macrophage cells. The antibody function was higher in the presence of serum complement.
Conclusion:

The peptide-based mAb demonstrated optimal performance in laboratory experiments which may be appropriate in investigation on OmpA in Acinetobacter pathogenesis and development of passive immunization as novel therapeutic approach.
The Effects of the Probiotic Cocktail On Modulation of the NF-kB and JAK/STAT Signaling Pathways Involving in Inflammatory Response in Bowel Disease Model
Authors: Aghamohammad Shadi , Sepehr Amin , Miri Seyedeh Tina , Najafi Saeideh , Rohani Mahdi , Pourshafie Mohammad Reza
Published: November 2021

Background: Probiotics are beneficial microorganisms which have beneficial effects on inflammatory responses, in part, through Janus kinase/signal transduction and activator of transcription (JAK/STAT) and inflammatory signaling pathways. Materials: Quantitative real-time polymerase chain reaction (qPCR) was used to analyze the expression of JAK/STAT and inflammatory genes (TIRAP, IRAK4, NEMO, and RIP) following treatment of HT-29 cell line with sonicated pathogen, Lactobacillus spp., Bifidobacterium spp. and a mixture cocktail. Cytokine assay also used to evaluate the production of IL-6 and IL-1B following the probiotic treatment. Results: Compared to sonicate pathogen treatment cells, our probiotics cocktail was down-regulated JAK genes and TIRAP, IRAK4, NEMO, and RIP genes in NF-kB pathway. The expression of STAT genes were variable following the probiotic treatment. The production of IL-6 and IL-1B were decreased after probiotic treatment. Conclusions: Our probiotics cocktail was shown to have anti-inflammatory effects on HT-29 cells by modulating JAK/STAT and NF-kB pathways; therefore, the use of Lactobacillus spp. and Bifidobacterium spp. probiotics as nutritional supplements may reduce inflammation-associated diseases such as inflammatory bowel disease.