bluuebunny/crossref_metadata_2025 huggingface dataset:
Program PERMATA BUNDA sebagai Upaya Pencegahan dan Penurunan Stunting di Kabupaten Barito Kuala
Authors: Wijaya Candra
Published: October 2023

Stunting merupakan masalah kesehatan yang berkaitan dengan peningkatan risiko keluhan, kematian serta hambatan pada masa pertumbuhan baik itu dari motorik maupun mental. program PERMATA BUNDA (Pemberian Makanan Tambahan Bagi Ibu Hamil dan Anak Balita) adalah salah satu upaya pemenuhan zat gizi spesifik dalam rangka mendukung 1000 Hari Pertama Kehidupan dan pemenuhan Standar Pelayanan Minimal Bidang Kesehatan, terutama untuk ibu hamil, bayi dan balita, serta mendorong terwujudnya generasi Barito Kuala yang tumbuh sehat dan bebas stunting. Hasil yang didapatkan dari implementasi PERMATA BUNDA dibutuhkan komitmen dan dukungan dari pemangku kebijakan, agar kebersinambungan manfaatnya dapat terus dirasakan masayarakat, karena Program PERMATA BUNDA terbukti dapat menurunkan kasus stunting di Barito Kuala, yaitu 16,86% pada tahun 2020 menjadi 12,56% pada tahun 2022 berdasarkan data ePPBGM tahun 2022. Kata Kunci: Permata Bunda; Stunting; Barito Kuala Stunting is a health problem associated with an increased risk of complaints, death, and obstacles during the growth period, both motor and mental. The PERMATA BUNDA program (Providing Supplementary Food for Pregnant Women and Toddlers) is one of the efforts to meet specific nutrition needs in order to support the First 1000 Days of Life and meet Minimum Service Standards in the Health Sector, particularly for pregnant women, infants, and toddlers, as well as encourage the creation of a new generation of Barito Kuala that are growing healthy and free of stunting. The Permata Bunda program is funded through budget synergy from the Village Community Empowerment Service for making ready-to-eat food menus for non-Chronic Energy Deficiency (KEK) pregnant women and undernourished toddlers, while for pregnant women and toddlers with KEK, the budget source is Health Operational Costs at the Health Center. The implementation of PERMATA BUNDA requires commitment and support from stakeholders, so that the benefits can continue to be felt by the community, because the PERMATA BUNDA Program has been proven to be able to reduce stunting cases in Barito Kuala, namely from 16.86% in 2020 to 12.56% in 2022 based on data from ePPBGM in 2022.
Edukasi “Bijak Menyikapi Issue Penggunaan Obat Sirup bagi Anak” kepada Kader Posyandu di Wilayah Kerja Puskesmas Landasan Ulin
Authors: Safitri Nita , Intannia Difa , Lingga Herningtyas Nautika , Muftadi Imam , Ratnapuri Prima Happy
Published: October 2023

Posyandu adalah tempat pelayanan kesehatan masyarakat dalam hal peningkatan status gizi masyarakat, kesehatan ibu dan anak sebagai upaya preventif dan promotif. Permasalahan isu adanya sirup obat yang mengandung etilen glikol dan dietilen glikol meresahkan ibu-ibu karena menyebabkan terjadinya gagal ginjal akut untuk anak-anak. Program promosi kesehatan ini bertujuan untuk memberikan edukasi, informasi dan pengetahuan terkait isu cemaran pada sirup obat kepada kader posyandu. Metode yang dilaksanakan yaitu penyuluhan secara langsung melalui presentasi dan diskusi interaktif, disertai dengan pembagian leaflet kepada 25 kader posyandu di wilayah kerja Puskesmas Landasan Ulin. Hasil dari program yang dilakukan peserta adalah peserta memiliki pemahaman yang lebih baik dan komprehensif terkait isu cemaran sirup sehingga dapat menyampaikan kembali informasi yang diperoleh kepada masyarakat di lingkungan agar lebih bijak dalam menyikapi berbagai isu cemaran sirup yang beredar. Kata Kunci: Cemaran, Dietilen Glikol, Etilen Glikol, Leaflet, Penyuluhan.  Posyandu is a public health service ceter in terms of improving nutritional status of the community, maternal and child health as a preventif and promotive effort. The issue of the existence of medicinal syrup containing ethylene glycol and diethylene glycol disturbs mothers because it causes acute kidney failure in children. This health promotion program aims to provide education, information and knowledge related to the issue of drug syrup contamination to posyandu activists. The method implemented was direct education through presentations and interactive discussions, accompanied by leaflet distribution to 25 posyandu activists in the Landasan Ulin Health Center area. The result of the program carried out by participants is that the participants have a better and comprehensive understanding of the issue of syrup contamination so that they can convey the information obtained to wider community in the Landasan Ulin Health Center area, so that they are wiser in responding to various issues of syrup contamination.
Edukasi Tentang Bijak Masyarakat Gunakan Antibiotik Untuk Pasien di Apotek Kimia Farma 217 Ulin Banjarmasin
Authors: Auliani Syifa , Desrianto Ricky , Normaidah Normaidah
Published: October 2023

Antibiotik merupakan suatu senyawa kimia yang dihasilkan oleh mikroorganisme yang dalam konsentrasi kecil mempunyai kemampuan menghambat atau membunuh mikroorganisme lain. Masalah saat ini yang terjadi adalah meningkatnya penggunaan antibiotik secara bebas dan keliru menyebabkan terjadinya antibiotika menjadi resisten terhadap bakteri serta penyimpanan yang tidak sesuai yang menyebabkan antibiotik tersebut rusak sehingga efektivitasnya hilang. Tujuan kegiatan promosi kesehatan ini adalah untuk memberikan edukasi serta melihat bagaimana tingkat pengetahuan pasien di Apotek Kimia farma 217 Ulin Banjarmasin tentang penggunaan Antibiotik. Metode yang dipilih dalam menyampaikan informasi menggunakan media leaflet dan Video. Hasil kegiatan dievaluasi melalui hasil dari nilai pre-test dan post-test. Kegiatan dilakukan terhadap 15 orang pasien. Berdasarkan hasil pada sesi pre-test diperoleh nilai total sebesar 55,4% dan setelah dilakukan post-test pengetahuan pasien meningkat dengan diperoleh nilai 85%.Kata Kunci: Antibiotik, Edukasi, Kimia Farma, Resisten.Antibiotics are chemical compounds produced by microorganisms which in small concentrations have the ability to inhibit or kill other microorganisms. The current problem that occurs is the increasing use of antibiotics freely and erroneously causing antibiotics to become resistant to bacteria and improper storage which causes the antibiotics to be damaged so that their effectiveness is lost. The purpose of this health promotion activity is to provide education and see how the level of knowledge of patients at Kimia Farma Pharmacy 217 Ulin Banjarmasin regarding the use of antibiotics. The chosen method of conveying information is using leaflets and videos as media. The results of the activity are evaluated through the results of the pre-test and post-test scores. The activity was carried out on 15 patients. Based on the results of the pre-test session, a total value of 55.4% was obtained and after the post-test, the patient's knowledge increased with a value of 85%.
Pengaruh Eco-enzym dan Trichoderma sp. Terhadap Intensitas Serangan Nematoda Puru Akar (Meloidogyne spp.) Pada Tanaman Seledri (Apium graveolens L.)
Authors: Yulida Annisa , Liestiany Elly , Fitriyanti Dewi
Published: October 2023

Organisme Penggangu Tanaman (OPT) yang sering menyerang tanaman seledri adalah Nematoda Puru Akar (NPA) yang disebabkan oleh Meloidogyne spp. yang biasanya menyerang akar tanaman seledri sehingga menyebabkan akar tanaman seledri menjadi bengkak. Salah satu upaya dalam pengendalian Organisme Pengganggu Tanaman (OPT) maka penelitian ini bertujuan untuk mengetahui pengaruh eco-enzym dan Trichoderma sp. dalam menekan intensitas serangan NPA pada tanaman seledri. Perlakuaan yang diberikan pada penelitian ini yaitu kontrol dan empat perlakuan Eco-enzym dan Trichoderma sp. Penelitian ini dilaksanakan selama 6 bulan dari penyemaian sampai panen. Hasil penelitian menunjukkan bahwa dalam setiap perlakuan memperlihatkan hasil yang beragam dalam mengendalikan serangan pada tanaman seledri. Perlakuan Eco-enzym dan Trichoderma sp. (satu waktu) mempunyai pengaruh untuk dijadikan sebagai pengendalian terhadap serangan NPA pada tanaman seledri karena pada perlakuan T4 Eco-enzym (10 ml) dan Trichoderma sp. (20gr) dengan persentase intensitas serangan 2,12%, menunjukkan hasil yang paling bagus dalam mengendalikan tingkat kerusakan NPA pada tanaman seledri
Uji Efektivitas Serbuk Cangkang Keong Mas plus Trichoderma spp. terhadap serangan Nematoda Puru Akar (Meloidogyne spp.) Pada Tanaman Seledri (Apium graveolens L.)
Authors: Imani Tegar , Liestiany Elly , Aidawati Noor
Published: October 2023

Seledri (Apium graveolens L.) merupakan tanaman budidaya yang memiliki aroma khas serta bernilai ekonomis tinggi dan potensial untuk dikembangkan di Indonesia. Salah satu organisme pengganggu tumbuhan (OPT) yang dapat mempengaruhi kualitas serta kuantitas dari produksi seledri adalah nematoda puru akar yang disebabkan oleh Meloidogyne spp. Penelitian ini bertujuan untuk mengetahui efektivitas serbuk cangkang keong mas plus Trichoderma spp. dalam mempengaruhi serangan nematoda puru akar (Meloidogyne spp.) pada tanaman seledri (A. graveolens L.). Penelitian ini dirancang menggunakan Rancangan Acak Lengkap (RAL) satu faktor. Faktor yang diujikan adalah pengaruh pemberian serbuk cangkang keong mas plus Trichoderma spp., pemberian serbuk cangkang keong mas dan pemberian Trichoderma spp. Ada 6 perlakuan dan 4 ulangan dengan parameter pengamatan yaitu intensitas serangan, populasi nematoda, jumlah tangkai dan berat basah tanaman seledri. Hasil penelitian menunjukkan bahwa pemberian serbuk cangkang keong mas plus Trichoderma spp. dapat mempengaruhi intensitas serangan puru akar dan mengurangi populasi nematoda ditanah sekitar perakaran, serta berpengaruh nyata pada jumlah daun (tangkai) dan berat basah tanaman seledri.
Efektivitas Tiga Sumber Mikro Organisme Lokal (MOL) Terhadap Intensitas Serangan Penyakit Moler pada Bawang Merah (Allium ascalonicum L.)
Authors: Kamilah Nisa , Salamiah Salamiah , Pramudi Muhammad Indar
Published: October 2023

This research aims to determine the effectiveness of three sources of Local Micro Organisms (MOL) on the intensity of moler disease attacks on shallot plants in peatlands. This study used a one-factor Completely Randomized Design (CRD) method consisting of 4 treatments and 5 replications, namely t0 = without administration of MOL (control), t1 = MOL of 10% leri water, t2 = MOL of leri water + 10% banana stem and t3 = MOL of water + 10% fish waste. The results of observations of the incubation period for moler disease for the first symptoms to appear were 14 days after inoculation (HSI). The percentage of moler disease is not influenced by the source of MOL. The highest percentage was shown in shallot plants that were not applied with MOL (71.43%). Meanwhile, the lowest percentage was found in shallot plants which were applied with MOL sources from water mixed with fish waste. This treatment also produced the highest number of tubers, namely 130,000 tubers/ha (356.11 kg/ha). Meanwhile, the largest tuber diameter was produced by plants that were applied with MOL leri water combined with banana stems.
Uji Efektivitas Serbuk Daun Kipait (Tithonia difersivolia) Terhadap Serangan Nematoda Puru Akar (Meloidogyne Spp) pada Tanaman Tomat
Authors: Yansyah Rahmat Wardani , Liestiany Elly , Fitriyanti Dewi
Published: October 2023

The tomato plant (Lycopersicum esculentum Mill.) is a horticultural plant that is popular with the public because it has good nutritional content, including vitamin A, vitamin B and vitamin C, which have quite high levels which are good for the body to consume. One of the pests that affects tomato plant production, both quality and quantity, is the attack by root knot nematodes (NPA), namely Meloidogyne spp. This research aims to determine the ability of kipahit leaf powder in several doses to suppress attacks by root knot nematodes (Meloidogyne spp.) on tomato plants (Lycopersicum esculentum Mill.). This research was designed using a one-factor Completely Randomized Design (CRD). The factors tested were the administration of kipahit leaf powder at doses of 25 grams, 50 grams, 75 grams and 100 grams with the control treatment not being given kipahit leaf powder as a comparison. This study had 5 treatments and 4 replications. The research results showed that giving 50 grams of kipahit leaf powder was able to reduce the intensity of root knot attacks and could reduce the nematode population around the roots of tomato plants. and had a significant effect on plant height at 46 and 60 days after transplanting.
The Utilization of Environment on Kambang Island as a Learning Resource on Social Studies: A Literature Study
Authors: Handy Muhammad Rezky Noor , Putra Muhammad Adhitya Hidayat , Zulfah Siti , Azizah Nor , Savitri Siti Nor Laila , Rusmaniah Rusmaniah
Published: October 2023

Utilization of the environment as part of social studies learning is currently the main topic for delivering teaching material in class. Kambang Island is a form of environment which is a unique natural tourist area with its flora and fauna. Therefore, the purpose of writing this article is to describe Kambang Island as a Social Sciences Learning Resources. The research is a literature study by examining manuscripts and books about Kambang Island as a social studies learning resource, through the stages of data collection, conceptualization, analysis and drawing conclusions. Kambang Island has unique flora and fauna which are characteristic of the Barito River region, which is based on the theme of class VII social studies teaching materials, namely People, Places and Environment, especially with environmental-based social studies learning resources. Kambang Island illustrates or delivers information to students using various learning media, whether in the form of visuals or audio-visuals, are brought into the classroom during learning in accordance with the learning plan prepared by the teacher.
Urgency Of Development Of Teaching Materials In Schools Of Social Studies Subjects
Authors: Samsul Mohammad
Published: October 2023

Bahan ajar tidak dapat dipisahkan dalam suatu proses pembelajaran untuk mencapai kompetensi siswa. IPS tidak terkecuali. Pengembangan bahan ajar adalah semua bahan yang dibutuhkan oleh pendidik dalam merencanakan dan mengevaluasi kegiatan pembelajaran. Semua materi yang terdapat dalam bahan ajar, termasuk pengetahuan, keterampilan, dan sikap, menjadi acuan bagi siswa. Lebih mudah bagi pendidik dengan bahan ajar untuk memahami materi dalam pembelajaran mendalam dan memfasilitasi pengajaran. Oleh karena itu, artikel ini bertujuan untuk mengidentifikasi pentingnya pengembangan bahan ajar mata pelajaran IPS di sekolah. Penelitian dilakukan dengan menggunakan metode studi pustaka. Studi literatur dilakukan untuk mengumpulkan data dan informasi yang sesuai, dan kemudian dilakukan diskusi naratif. Hasil identifikasi menunjukkan bahwa pengembangan bahan ajar bersifat konstruktif bagi pendidik dan peserta didik dalam mencapai kegiatan belajar mengajar. Pengembangan bahan ajar mata pelajaran IPS dapat dilakukan melalui tiga pola, yaitu mulai dari awal, kemas ulang informasi dan kompilasi di sekitar teks.
The Readers Community of the Journal “Bulletin of Knowledge” (1903–1918) as an Example of Successful Communication between the Editorial Board and the Audience
Authors: Moreva O. V.
Published: October 2023

The journal “Bulletin of Knowledge“ (1903–1918) was popular in various readership groups, aspiring to self-education. The purpose of the article is to determine the role of the communicative strategy of the editor–publisher of the journal V. V. Bitner for the creation of the community of “Bulletin of the Cognoscenti”, which was a “community of interpreters” (according to S. Fish), within the framework of the history of reading. The sources for the analysis were a set of journals stored in the Sverdlovsk Regional Universal Scientific Library named after V. G. Belinsky (Yekaterinburg), editorial articles, letters from readers, memoirs of V. V. Bitner and his contemporaries. Changes in the volume of the journal’s headings help to trace the history of the creation of a of readers community. The journal had sections to answer subscribers’ questions, as well as headings to publish letters to find friends, requests for help, and discussions of topical contemporary issues. “Discussion branches” of separate topics, continued sometimes for a year or more. Members of the readers’ community also interacted in real life. Their “disvirtualization” took place thanks to the organization of lectures, excursions and congresses of subscribers. The titles of the headings, examples of readers’ letters and the assessment of contemporaries indicate the uniqueness of this educational project. The portrait of V. V. Bitner by I. E. Repin, commissioned by subscribers for the tenth anniversary of the journal, can serve as an evidence of respect and admiration of the editorpublisher work. The commercial success of the “Bulletin of Knowledge” allowed V. V. Bitner to implement other publishing projects.
The Activities of Russian Libraries in the Dissemination of Scientific Knowledge
Authors: Kurmysheva L. K.
Published: October 2023

The issue of spreading scientific knowledge is relevant at the present stage of development of society. The library, as the most accessible cultural institution, is able to ensure the dissemination of this knowledge in all social strata of the population. The purpose of the article is to study the intensity and forms of events of scientific, popular science and educational content of federal, republican, regional and regional Russian libraries, reflected on official websites. The article deals with information about the popular scientific activities of the leading Russian libraries. The ongoing projects and mass events of scientific, popular science and educational content are described. Content analysis has become the main method of collecting information. The study was performed at the end of 2022 and the beginning of 2023. The site analysis showed that libraries, as cultural institutions, hold a sufficient number of various mass events in the form of lectures, master classes, intellectual games, quizzes, but the scientific or popular science content of these events is not always confirmed. Basing on two stages of the study the following conclusions were made: science promotion activities were present in an average of 33 % of the libraries surveyed. The most popular form of such events was a lecture with the participation of a guest lecturer. Most of the activities were aimed at young people.
Perkembangan dan Pola pertumbuhan Sektor Pertanian dalam Pembangunan Ekonomi
Authors: Syahrial Syahrial , Harahap Nurkholiza , Martadona Ilham
Published: October 2023

Sektor pertanian merupakan salah satu sektor yang memiliki peluang dalam kegiatan pembangunan perekonomian. Penelitian ini bertujuan untuk 1) Menganalis perkembangan ekonomi sektor pertanian di KabupatenSolok. 2) Menganalisis struktur pertumbuhan ekonomi sektor pertanian di Kabupaten Solok. Metode dasar yang digunakan adalah Indeks Diversitas Entropi dan Analisis Tipologi Klassen. Hasil dari analisis diketahui tiga subsektor dalam sektor pertanian di Kabupaten Solok masih belum berkembang. Pertumbuhan ekonomi sektor pertanian di Kabupaten Solok yang dari 61 komoditas meliputi subsektor pangan, hortikultura, perkebunan merupakan yang paling banyak ditempati di terbelakang sebesar 39 persen, prima 23 persen, berkembang 20 persen dan potensial 18 persen. Pemerintah harus mampu membuat kebijakan pada peningkatan produksi mengutamakan komoditas maju dan tumbuh cepat dan komoditas terbelakang ditingkatkan dengan melakukan penyuluhan maupun meningkatkan tegnologi pertanian sehingga mampu meningkatkan perekonomian di Kabupaten Solok.
Faktor-Faktor Yang Berpengaruh Terhadap Motivasi Petani Dalam Pembuatan Pupuk Organik Cair Dari Limbah Tempe
Authors: Anantariya Ucca , Romadi Ugik , Harwanto Harwanto
Published: October 2023

Abstrak
Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berpengaruh terhadap motivasi petani dalam pembuatan pupuk organik cair limbah tempe. Penelitian ini dilakukan di Desa Beji Kecamatan Junrejo Kota Batu Jawa Timur pada bulan Maret-Mei 2023. Pengambilan sampel dilakukan dengan metode purposive sampling dimana dari 11 kelompok tani terpilih 3 kelompok tani yang masuk dalam  kriteria yang ditentukan dengan jumlah 70 orang. Pengumpulan data dilakukan dengan wawancara dan menggunakan kuesioner yang telah diuji validitas dan reliabilitas. Analisis data yang digunakan yaitu regresi linier berganda dengan SPSS 25. Hasil penelitian menunjukan bahwa faktor-faktor yang berpengaruh terhadap motivasi petani dalam pembuatan pupuk organik cair dari limbah tempe yaitu umur, lama berusahatani, pendidikan, keuntungan dan kerumitan. Luas  lahan, kekosmopolitan, serta sarana dan prasarana tidak berpengaruh nyata terhadap motivasi petani.
The Effect Of Collaborative Learning Model Combined with Video Media on Senior High School Student’s Critical Thinking Skill and Biology Learning Outcomes in Regional Coffee Plantation Schools in Jember City
Authors: Pratiwi Ersa Setia , Suratno Suratno , Siswati Bea Hana
Published: October 2023

The characteristics of students who go to school in a coffee plantation environment tend to be less active in learning, resulting in student saturation and low cognitive learning outcomes of students. This study aims to analyze the effect of collaborative learning models combined with video media on critical thinking skills and biology learning outcomes of class X SMAN Jenggawah with a quasi-experimental research type using a pre-test post-test control group design. The learning design by forming the class into small groups observing videos of arthropods found in the coffee plantation environment. Data collection was obtained from the implementation of observations, tests, and questionnaires. Data analysis was tested using the ANACOVA test for critical thinking skills and learning outcomes in the cognitive domain of students, and independent sample t-test for learning outcomes in the affective and psychomotor domains of students. The results showed a significance value of 0.000 <0.05 in critical thinking skills and a significance value of 0.001 <0.05 in learning outcomes in the cognitive domain, so the collaborative learning model had a significant effect on critical thinking skills and learning outcomes in the cognitive domain of class X high school students in coffee plantation area. Meanwhile, a significance value of 0.126 > 0.05 in the affective domain of learning outcomes, and a significance value of 0.213 > 0.05 in the psychomotor domain of learning outcomes, so that the collaborative learning learning model has no significant effect on critical thinking skills and cognitive learning outcomes of class X students high school in a coffee plantation area.
Synergistic Effects of Paclitaxel and Sulforaphane in Prostate Cancer Treatment: Mechanistic Insights for Optimizing Combination Therapy
Authors: Habib Tito Naeem , Altonsy Mohamed Omar , Ghanem Salah Abdelmoneim , Salama Mohammed Said , Hosny Mai Abd El Hafieth
Published: October 2023

Background: In cancer therapy, combining treatments can result in additive and synergistic outcomes, reducing the development of drug resistance compared with monotherapy. We propose that combining Paclitaxel (Taxol, PTX) with Sulforaphane (SFN) may result in better treatment outcomes in prostate cancer. Understanding the mechanism of drug synergy, as opposed to simply knowing which drugs to combine, enables further optimization of advantageous drug interactions and can provide efficient therapeutic strategies in preclinical research.
Methods: We measured apoptosis, cell cycle, and expression of Bax and Bcl2 in response to individual and combined treatments of PTX and SFN in PC-3 and LNCaP cells. Different concentrations of PTX, SFN, and their combination were used. We conducted Annexin V/PI positivity and data analysis using a flow cytometer and guava data acquisition and analysis software. Statistical analyses and graph generation were performed using Graph-Pad Prism 6 and Microsoft Excel software. Student’s t-tests or one-way analysis of variance with Tukey’s correction were used to determine the significant difference between mono- and combination treatments.
Results: The effect of PTX or SFN treatments on reducing cell viability increased in a dose-dependent manner. Combined treatment enhanced PTX’s effects and reduced the EC50 values of both drugs compared to individual treatments. Flow cytometry analysis revealed that PTX or SFN treatments redistributed cell-cycle phases by inducing S-phase arrest and increasing the apoptotic cell population in PC-3 cells. These effects were further enhanced in the PTX+SFN combination group. Interestingly, the combination treatments did not affect the necrotic cells. Caspase-3 cleavage and morphological deformations of the cell nuclei were examined by western blot and fluorescent microscopy in response to mono- and combination treatments, indicating apoptotic cell death.
Conclusion: The PTX or SFN treatments differentially modulated the expression of Bax and Bcl2 in PC-3 and LNCaP cell lines, and the combined treatment enhanced these effects in favor of cell apoptosis versus survival. Our data indicated that combination therapy of PTX and SFN significantly increased Bax protein expression and Bax: Bcl2 ratio compared to PTX or SFN individual treatments. These findings could help develop new biomarkers and guide therapy choices. Understanding the mechanism of drug synergy is essential to optimize drug interactions and provide efficient therapeutic strategies in preclinical research.
Development and Internal Validation of a Novel Pre-Transplant Biomarker Panel to Predict Post-Liver Transplant Mortality
Authors: Panayotova Guergana G. , Simonishvili Sopio , Nguyen Duc T. , Graviss Edward A. , Aware Nikita , Manner Carl J. , Minze Laurie J. , Ayorinde Tumininu , Qin Yong , Jin Lianhua , Lemenze Alexander , Mysore Krupa R. , Moore Linda , Paterno Flavio , Saharia Ashish , Mobley Constance M. , Amin Arpit , Hobeika Mark J. , Pyrsopoulos Nikolaos , Li Xian C. , Guarrera James V. , Ghobrial R. Mark , Lunsford Keri E.
Published: October 2023

Current scoring systems accurately predict risk of pre-liver transplant (LT) mortality but fall short in estimation of post-LT survival. This study seeks to identify biomarkers of pre-LT immune dysfunction that predict mortality following LT. From 10/1/13-3/23/21, 279 cirrhotic patients underwent assessment of plasma biomarker (Luminex) and clinical variables immediately prior to LT (T0). Cox-proportional hazards modeling identified HCV IgG, Fractalkine, and MMP3 as multivariate predictors of 1-year mortality, with covariate selection by clinical importance and LASSO methodology. These were utilized to comprise the novel Liver Immune Frailty Index (LIFI), which stratifies recipients into -low, -moderate, and –high risk tertiles. One-year mortality was 1.4%, 12.7%, and 58.3% for LIFI-low, -moderate, and -high, respectively. Internal validation through bootstrap resampling with 2000 replicates demonstrates LIFI predicts early post-LT mortality with C-statistic=0.84 and Brier score of 0.04. LIFI may identify patients at risk for persistent severe immune dysfunction and early mortality following LT.
The effect of urbanization and behavioral factors on coyote net displacement and its implications for seed dispersal
Authors: Gelmi-Candusso Tiziana A. , Wheeldon Tyler J. , Patterson Brent R. , Fortin Marie-Josée
Published: October 2023

Coyotes (Canis latrans) may be important seed dispersal vectors in urban areas, given their omnivorous diet and wide-ranging movement patterns potentially able to bypass fragmentation. Yet, fragmentation itself, anthropogenic food sources, and human activity can limit their natural movement patterns. Previous research has found urbanization limits movement range across mammals; however, it remains unclear the degree to which this may cascade into seed dispersal as seed retention time also plays an important role in seed dispersal distance. Additionally, social and temporal changes in behavior influence coyote movement patterns, likely interacting with the effect of urbanization on net displacement and, consequently, seed dispersal. We used GPS telemetry data to analyze the effect of urbanization on coyote net displacement (n=94 individuals), in interaction with social and temporal factors, for a series of seed retention timeframes. We found that urbanization led to shorter net displacement in comparison to rural areas. The effect of urbanization increased with increasing seed retention timeframe and disproportionately affected long-distance seed dispersal. Seasonality influenced the effect of urbanization to a smaller extent than social status. Social status had a strong interaction effect, as urbanization negatively impacted the net displacement of transient and dispersing coyotes but had a negligible influence on resident coyotes. Territoriality was likely the main limiting factor for the latter, whereas the former, which were wider ranging, were likely most affected by the landscape configuration. In terms of seasonality, climate seasons explained variability in the data better than biological seasons, where net displacement remained more stable across climate seasons in urban areas, as opposed to rural areas, where net displacement increased during winter and decreased during summer. Interestingly, despite the urban effect, coyote net displacement varied across social statuses and seasons in both landscape types, suggesting coyotes can provide a heterogenous seed dispersal contribution within and across plant species. Future research on fine-scale movement patterns and scat analysis is needed to better understand the cascading effects of decreased long-distance net displacements on urban plant populations.
Dynamics of topological phonon boundary modes in polymer chains and supramolecular lattices on surfaces
Authors: Palma Carlos-Andres , Polthier Konrad , Rondomanski Jakub , González José Cojal , Rabe Jürgen
Published: October 2023

In topological band theory, phonon boundary modes with non-trivial topology feature desirable properties for atomically-precise technologies, such as robustness against defects, waveguiding and one-way transport. Topological phonon properties remain to be studied both theoretically and experimentally in low-dimensional materials at the atomistic level, such as polymer chains and self-assembled supramolecular lattices, especially under thermal fluctuations. Here we show by means of molecular simulations that polymer chains and weakly-interacting supramolecular lattices following modified Su-Schrieffer-Heeger (SSH) phonon models with heavy boundaries, express robust topological phonon boundary modes under thermal fluctuations. The topological boundary modes propagate upon excitation of a single molecule, contrary to free boundary modes. Our work is an entry to topological vibrations and their corresponding non-Euclidean metric in supramolecular systems, and may find applications in the realization of Hall effect phonon analogues at the molecular scale
Development of Industrial Occupational Safety and Health Models in Manufacturing Industries the Case of Akaki Basic Metal Industry
Authors: Tesfaye Fasil Kebede
Published: October 2023

Manufacturing is a significant sector of the economy in many nations and is frequently regarded as an engine of economic expansion, particularly in developing nations. Despite its importance, the metal sector is seen as unsafe due to frequent and high accident rates as well as worker health issues. Therefore, the primary goal of this research is to create a safety model with the goal of development in occupational safety and health in order to reduce workplace injuries, diseases, and deaths in the Akaki Basic Metal Industry. The hypothesized model was developed and tested on a sample 215 respondents who worked for production businesses. The Statistical Package for the Social Sciences (SPSS) version 23.0 was used to enter and analyze the acquired data, and the Analysis Moment of Structure (AMOS) version 21 software was used to build the model. Through the use of structural equation modeling (SEM) and confirmatory factor analysis (CFA), research models were examined and confirmed. A good-fit structural model (PCLOSE = 0.001, Goodness of Fit Index = 0.971, Root Mean Square Error of Approximation = 0.121, Comparative Fit Index = 0.986 and TLI = 0.906) indicated that Safety culture, safety police and safety climate constructs direct influence on firm productivity. The new structural model can be used to provide better understanding of the links between firm productivity indicators and contributing components, and make stronger recommendations for effective intervention in construction projects
Reflections of the Spices Mentioned in the Health Recipes Applied for Centuries by Ibn Sina on the Ottoman Palace Cuisine
Authors: Başar Fatma , Başar Burak , Akoğul Emre
Published: October 2023

The relationship between diseases and nutrition, along with the practice of recommending specific foods and beverages in addition to medications, is a phenomenon that has persisted from ancient times to the present day. The utilization of meat, vegetables, herbs, and spices in the context of dietary therapy is a common approach. In Ottoman palace cuisine, the medical prescriptions administered by Ottoman physicians influenced the culinary creations of the palace. Therefore, this study aims to assess the use of spices in the preparation of dishes within Ottoman palace cuisine and their role within Ibn Sina's medicinal formulations. In essence, this research seeks to shed light on the culinary philosophy of the palace kitchen culture, which was deeply influenced by the longstanding tradition of Ottoman medicine that developed over an extensive period.
The impact of cultural, socioeconomic, behavioral and health disadvantages on the incidence and severity of chronic kidney disease:A case- control study of Uddanam region of Andhra Pradesh, India.
Authors: Pampana Hari Ram , Addanki Sadguri , Lakkamraju Dhanunjaya Varma , Godi Sudhakar , Gangisetti Paddaiah
Published: October 2023

BackgroundPresently both developed and developing countries are suffering from chronic kidney disease (CKD) worldwide. CKD with unknown etiology rapidly and silently affects people without any prior symptoms. Loss of renal function due to progressive loss of glomerular filtration rate (GFR) and co morbidities is an important factor leading to adult mortality. This study aimed at to investigate the impact of cultural, socioeconomic, behavioral and health factors on chronic kidney disease prevalence and severity in Kaviti and Kanchili Mandals within the Uddanam region of North Coastal Andhra Pradesh, India.MethodsA case‒control study was conducted on 2806 participants (1001 CKD patients and 1001 healthy controls in Kaviti Mandal and 402 CKD patients and 402 healthy controls in Kanchili mandal of the Uddanam region. Logistic and multiple regression analyses and independent t-tests were applied to measure the association between selected parameters such as average spending per month on transport, diagnosis and medicine juxtaposed to various parameters of CKD and normal families.ResultsIn the Uddanam region, the patient’s average spending costs per month on transport to the hospital, diagnosis, and medicine were 919/-, 1225/-, and 2076/-, respectively, and stage 4 and 5 patients were spent more money for treatment of the disease. The logistic regression analysis revealed that the people in the open category(OROC/SC&ST= 5.132, 2.513-10.48), lower economic category (ORLOWER/UPPER= 7.011, 1.482-33.17), farmers (ORFARMER/ANY OTHER=1.620 (1.226-2.14), those in the education system primary education group (ORPRIMARY/COLLEGEANDABOVE=3.246,9.598-25.766), hypertensive individuals (ORYES/NO= 5.088,4.2-6.16) and people who had other ailments (ORYES/NO= 3.714, 2.992-4.61) had a significant risk association with CKDu.ConclusionThe present study revealed that living in rural areas and belonging to lower socioeconomic status per se play a significant role in the causation of chronic kidney disease and that these CKD patients spend more money to treat the disease as it progresses. The improvement of health care facilities especially specialties dealing with kidney diseases and creating awareness of CKD risk factors are needed.
Regional trans-arterial immunotherapy combined with intravenous chemotherapy in patients with locally advanced cervical cancer as preoperative neoadjuvant therapy: A case series study
Authors: Huang Qidan , Tong Chongjie , Huang Zhimei , Gu Yangkui , Yang Fan , Zhou Wenhao , Yan Shumei , Carly Ha Ka Lee , Luo Nanbin , Xiong Ying
Published: October 2023

Background: This study was to evaluate the effectiveness and safety of the preoperative regional trans-arterial immunotherapy combined with intravenous chemotherapy in patients with locally advanced cervical cancer (LACC).
Methods: Trans-arterial programmed cell death receptor 1 (PD-1) monoclonal antibody infusion combined with intravenous paclitaxel-cisplatin chemotherapy was adopted as neoadjuvant therapy in six patients with primary LACC (stage IIB-IVA) who were willing to undergo surgical resection, and treatment effectiveness was evaluated according to the RECIST 1.1 criteria. If the local tumor was regressive and assessed as operable, surgery was performed, and postoperative adjuvant therapy was selected based on the histopathological findings.
Results: One patient was discontinued the neoadjuvant therapy from the study due to an allergic reaction during the 2nd course and underwent surgical resection directly. Five patients achieved partial response after neoadjuvant therapy with an objective response rate of 100% and a surgical conversion rate of 100%. All patients had R0 resection. Serious adverse events did not occur during neoadjuvant therapy. The six patients were followed up for 15-30 months (median, 23.5 months) and none of them relapsed.
Conclusions: Trans-arterial PD-1 monoclonal antibody infusion combined with intravenous paclitaxel-cisplatin as neoadjuvant therapy in patients with LACC showed a higher objective response rate, surgical conversion rate, and safety with satisfactory near-term outcomes. Further investigation is required to substantiate the outcome of regional trans-arterial infusion immunotherapy combined with intravenous chemotherapy as an alternative treatment modality for LACC.
Metabolomic screening of radioiodine refractory thyroid cancer patients and the underlying chemical mechanism of iodine resistance
Authors: Zheng Weihui , Tang Xi , Dong Jinyun , Feng Jianguo , Chen Min , Zhu Xin
Published: October 2023

Background: Radioiodine refractory (RAIR) patients do not benefit from iodine-131 therapy. Thus, timely identification of RAIR patients is critical for avoiding ineffective radioactive iodine therapy. In addition, determining the causes of iodine resistance will facilitate the development of novel treatment strategies.
Methods: This study was comprised of 20 RAIR and 14 non-radioiodine refractory (non-RAIR) thyroid cancer patients. Liquid chromatography-mass spectrometry was used to identify differences in the serum metabolites of RAIR and non-RAIR patients. In addition, chemical assays were performed to determine the effects of the differential metabolites on iodine uptake.
Results: Metabolic pathway enrichment analysis of the differential metabolites revealed significant differences in the phenylalanine and tyrosine metabolic pathways. Notably, quinate and shikimic acid, metabolites of the tyrosine pathway, were significantly increased in the RAIR group. In contrast, the phenylalanine pathway metabolites, hippuric acid and 2-phenylacetamide, were markedly decreased in the RAIR group. Thyroid peroxidase plays an important role in catalyzing the iodination of tyrosine residues, while the ionic state of iodine promotes the iodination reaction. Quinate, shikimic acid, hippuric acid, and 2-phenylacetamide were found to be involved in the iodination of tyrosine, which is a key step in thyroid hormone synthesis. Specifically, quinate and shikimic acid were found to inhibit iodination, while hippuric acid and 2-phenylacetamide promoted iodination.
Conclusions:Abnormalities in phenylalanine and tyrosine metabolic pathways are closely associated with iodine resistance. Tyrosine is required for thyroid hormone synthesis and could be a potential cause of iodine resistance.
The comprehension of bioremediation for the isolation and characterization of heavy metal tolerant Aeromonas sanarellii bacteria in the wastewater-contaminated soil
Authors: Aravind Chidambaram , Sivaji Subhashini , Nagaraj Harashavardhan , Ramya Priyanga Prasanna , Jayaram Lavanya , Anandakumar Shanmugam , Sivakumar Durairaj , Prabu Dhandapani
Published: October 2023

The large number of toxic metals accumulate in water and soil environment as a result of unmanaged industrial waste disposal, significantly impacting a variety of health-related issues. Heavy metal resistance is very high among microorganisms in the soil's rhizosphere. In this work, we isolated such naturally existing rhizosphere bacteria Aeromonas sanarellii (A. sanarellii) from heavily contaminated soil in the Anakaputhur area, southern part of Chennai city, India. On the basis of the partial amplification of 16S rRNA using new primers, A. sanarellii was molecularly identified. Then, 33 strains were used to align the sequence in order to study phylogenetic relationships using the neighbour joining method. This study assessed its ability of reducing and detoxifying heavy metals based on the results of subsequent testing. The effective concentration (EC50) and the internationalization of heavy metals were determined using spectrophotometric method. The structural changes in tolerant bacteria were studied using Scanning electron microscope (SEM). Protein profiling was performed using SDS PAGE and MALDI TOF analysis. Amount of metallothionein produced upon exposure was measured by using UV-Vis spectrophotometer. This study found that, as a consequence, selecting A. sanarellii based on their heavy metal resistance and biodegradation ability could serve as a starting point for developing potential bioremediation agent for toxic effluent treatment technology.
“I only seek treatment when I am ill”: Experiences of hypertension and diabetes care among adults living with HIV in urban, Tanzania
Authors: Ottaru Theresia A. , Wood Christine V. , Butt Zeeshan , Hawkins Claudia , Hirschhorn Lisa R. , Karoli Peter , Shayo Elizabeth H. , Mettah Emmy , Chillo Pilly , Siril Hellen , Kwesigabo Gideon
Published: October 2023

Background
For adults living with HIV (ALHIV) and comorbidities, access to comprehensive healthcare services is crucial to achieving optimal health outcomes. This study aims to describe lived experiences, challenges, and coping strategies for accessing care for hypertension and/or diabetes (HTN/DM) in HIV care and treatment clinics (CTCs) and other healthcare settings.
Methodology
We conducted in-depth interviews with 33 ALHIV with HTN (n=16), DM (n=10), and both (n=7), purposively recruited from six HIV CTCs in Dar-es-Salaam, Tanzania. Thematic content analysis was guided by the 5As framework domains (availability, accommodation, affordability, acceptability, and accessibility).
Results
Participants sought HTN/DM care including screening and management at non-CTC health facilities due to the limited availability of such services at HIV CTCs. However, healthcare delivery for these conditions was perceived as unaccommodating and poorly coordinated. The need to attend multiple clinic appointments for the management of HTN/DM in addition to HIV care was perceived as frustrating, time-consuming, and financially burdensome. Participants reported difficulty paying for their HTN/DM medications and non-HIV CTCs providers’ consultation costs. High costs of care and transportation, limited understanding of comorbidities, and the perceived complexity of HTN/DM care contributed to HTN/DM treatment discontinuity among ALHIV. As a means of coping, participants frequently monitored their own HTN/DM symptoms at home. When symptoms were a problem, participants utilized community pharmacies and dispensaries near their residences to check blood pressure and sugar levels and obtain medications. These approaches were preferred to seeking care at the HTN/DM care sites due to the costs. Limited education in HTN/DM management was provided at all health facilities including HIV CTCs. Participants expressed a preference for non-pharmaceutical approaches to comorbidity management such as lifestyle modification and herbal therapies because of concerns about side effects and perceived ineffectiveness of HTN/DM medications. Participants also preferred integrated care and focused health education on multimorbidity management at HIV CTCs.
Conclusion
Our findings highlight significant barriers to accessing HTN/DM care among ALHIV, mostly related to affordability, availability, and accessibility. Integration of NCD care into HIV CTCs, with attention to cost and other barriers, could greatly improve ALHIV health access and outcomes and align with patient preference.
Embedding patient safety in a scaffold of interprofessional education; a qualitative study with thematic analysis
Authors: Guraya Shaista Salman , Akhtar Muhammad Umair , Sulaiman Nabil , David Leena R. , Jirjees Feras Jassim , Awad Manal , Kawas Sausan AL , Taha Mohamed Hassan , Haider Mohamed , Dias Jacqueline Maria , Kodumayil Shada Aysha , Dash Nihar Ranjan , Al-Qallaf Amal , Hasswan Ahmed , Salmanpour Vida Abdolhamid , Guraya Salman Yousuf
Published: October 2023

BackgroundRegardless of a proliferation of interest in reducing unsafe practices in healthcare, threats to patient safety (PS) remain high. Moreover, little attention has been paid towards the role of interprofessional education (IPE) in enhancing PS. This qualitative study was conducted to unfold the insights of the senior medical, dental and health sciences students at the University of Sharjah (UoS) in the United Arab Emirates (UAE) about PS in an online IPE-based workshop.MethodsThis inductive qualitative study was conducted on senior medical and health students at the Colleges of Medicine, Dental Medicine, Health Sciences, and Pharmacy of UoS.During an online workshop, students discussed plausible solutions for four real practice-based clinical scenarios with elements of unsafe healthcare practices. During the breakout rooms, the students exhibited high level of articulation and proactively participated in discussions. The data from the online workshop were transcribed and then coding, categorizing, and labelling of recurrent themes was carried out. Multiple individual deliberations, consolidation, incorporation of the identified preliminary themes, and merging and reorganizing sub-themes led to a final thematic framework.ResultsThis work delved into the perspectives of 248 students concerning PS in interprofessional settings in an online workshop. The iterative process of data transcription, curating and qualitative analysis surfaced 32 codes. Later, the inductive qualitative analysis yielded five themes with distinct yet interconnected nested subthemes in the context of PS in IPE settings. These themes of information sharing and grounding (problem-solving, social skills), maintaining communication (clinical reasoning, shared mental model), executing interprofessional activities (collaborative practice, collaboration scripts), professional cognitive abilities (cognitive maturity, metacognition), and negotiating professional identities (systematic change, socio-economic scaffolding) emerged as fundamental pillars for enhancing PS in healthcare.ConclusionOur study demonstrated the outcome of an innovative and team-based workshop which embedded PS within a scaffold of IPE environment. This research calls for the incorporation of the emerging areas of clinical reasoning, problem solving, collaborative practice, and shared mental model into medical curricula for structured IPE in improving PS domains in medical education. These findings underscore the need for multifaceted dimensions of IPE imperatives for cultivating collaborative competence.