bluuebunny/crossref_metadata_2025 huggingface dataset:
Scale Estimation for Design Decisions in Virtual Environments: Understanding the Impact of User Characteristics on Spatial Perception in Immersive Virtual Reality Systems
Authors: Azarby Sahand , Rice Arthur
Published: September 2022

User spatial perception in different virtual environments may vary based on specific user characteristics and the features of the Virtual Reality (VR) system. This research explored the impacts of user characteristics such as age, gender, and design knowledge on spatial decision-making by comparing an Immersive Virtual Reality Interactive Environment (IVRIE) with a traditional Virtual Reality system (also known as desktop-based Virtual Reality system, abbreviated herein as the DT system). Users’ spatial perceptions when using IVRIE and a DT system were studied with regard to the features of the different systems, including the types of immersion and interaction, users’ perceptions of human body scale, and how the environments were explored. The factors affecting the two systems included texture variation, type of enclosure, and spatial function. Inferential testing using quantitative data was applied to identify differences between the two systems in terms of participants’ actual design outcomes. The results showed that based on the type, spatial characteristics, and texture of spaces, perception filters could have both active and inactive roles in impacting the spatial decision-making of participants between the two systems. In addition, between the two systems, participant characteristics had more impact on size variations for both types of spaces—fully enclosed and corridors—for accommodating larger groups.
Monitoring Axial Force Development in a Super-Long Pile during Construction Using BOFDA and Data Interpretation Approaches: A Case Study
Authors: Li Dongning , Ma Deshan , Su Dong , Rao Shaohua , Wang Wenbin , Hong Chengyu
Published: September 2022

Long-term monitoring data for super-long piles are scarce and valuable. This paper reports axial strain measurements of a cast-in-place large-diameter pile embedded 76.7 m into a “weathered trench” of granite in Nanshan District, Shenzhen, China, using BOFDA monitoring technology. An approach based on the load-transfer method to interpret data is proposed, in which the axial load at the pile head and the shear behavior at the pile–soil interface can be analyzed. Results show that these data can well reflect the increase in axial strain as the number of floors built increases, although there is deviation related to fiber cable bending due to the installation and compaction of concrete, and the complex loading condition at the pile head. Sensitivity analysis of parameters disclosed that the friction angle between the soil and the pile was approximately 10° for the cast-in-place pile monitored in this study, which is approximately one third of the interface friction angle, considering the slurry cake effect. The average axial force exerted on the pile head induced by building one floor ranged from 116.00 kN to 297.43 kN; this increased with the number of floors built and the total loads of the superstructure. This implies that the raft carried a large portion of the structural load during the early construction stage; piles gradually carried a major portion of the increased load due to continuous construction. The overall mobilized percentage of skin friction was approximately 40.8% when 40 floors were built, and the pile had the potential to carry more axial load.
Damage Detection of Steel Truss Bridges Based on Gaussian Bayesian Networks
Authors: Sun Xiaotong , Xin Yu , Wang Zuocai , Yuan Minggui , Chen Huan
Published: September 2022

This paper proposes the use of Gaussian Bayesian networks (GBNs) for damage detection of steel truss bridges by using the strain monitoring data. Based on the proposed damage detection procedure, a three-layer GBN model is first constructed based on the load factors, structural deflections, and the stress measurements of steel truss bridges. More specifically, the load factors of the structures are defined as the first-layer network nodes, structural deflections are considered as the second-layer network nodes, and the third-layer nodes of the GBN model are built based on the stress data of the truss elements. To achieve the training for the constructed GBN model, the finite element analysis of the bridge structures under the different load factors is performed. Then, the training of the network is performing by using the maximum likelihood estimation approach, and the optimized network parameters are obtained. Based on the trained network model, the measured load factors and the corresponding stress monitoring data of a limited number of truss elements are considered as input, and the stress measurements of all truss elements of bridges can be accurately estimated by searching the optimized topological information among network nodes. For a steel truss bridge, when the truss elements are damaged, the stress states of the damaged elements will be changed. Therefore, a damage index is further constructed for damage detection of steel truss bridges based on the changed stress states of those damaged elements. To verify the feasible and effective use of the proposed damage detection approach, an 80 m steel truss bridge with various damage cases was conducted as numerical simulations, and the investigation results show that the trained GBN can be accurately used for stress prediction of steel truss bridges, and the proposed damage index with the estimated stress data can be further applied for structural damage localization and quantification with a better accuracy. Furthermore, the results also suggest that the proposed damage detection procedure is accurate and reliable for steel truss bridges under vehicle loads.
Comparison of Second-Line Treatments for Patients with Platinum-Resistant Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Systematic Review and Bayesian Network Meta-Analysis
Authors: He Yan , Zeng Junsong , Wei Zhigong , Huang Yan , Yang Lianlian , Hu Xiaolin , Su Yonglin , Peng Xingchen
Published: September 2022

Several new drugs and combination strategies can be used to treat patients with recurrent or metastatic head and neck squamous cell carcinoma in the second-line treatment. Questions regarding the relative efficacy and safety of any two of the multiple second-line treatment strategies have emerged. This study aims to compare second-line treatments for patients with platinum-resistant recurrent or metastatic head and neck squamous cell carcinoma. Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched to identify relevant articles. Direct and indirect evidence in terms of the objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and treatment-related adverse events grade ≥ 3 (grade ≥ 3 trAE) were analyzed in this Bayesian network meta-analysis. A total of twenty-three trials involving 5039 patients were included. These studies compared 20 different treatments, including the standard of care (SOC: docetaxel, methotrexate, or cetuximab), PD-1 inhibitors (nivolumab or pembrolizumab), durvalumab, tremelimumab, durvalumab + tremelimumab, palbociclib + SOC, tivantinib + SOC, sorafenib + SOC, EMD1201081 + SOC, vandetanib + SOC, PX-866 + SOC, 5-fluorouracil + SOC, cixutumumab + SOC, gefitinib + SOC, cabazitaxel, nolatrexed, duligotuzumab, zalutumumab, gefitinib, and afatinib. Among the currently available treatment options, compared to the standard of care (SOC: docetaxel, methotrexate, or cetuximab), the PD inhibitor significantly improved OS, ORR, and grade ≥ 3 trAE. Afatinib presented a better PFS and ORR than the SOC. Compared with afatinib, the PD-1 inhibitor had a better OS but a worse PFS. In conclusion, compared to the SOC, the PD-1 inhibitor significantly improved the OS, ORR, and grade ≥ 3 trAE. Afatinib presented a better PFS and ORR than the SOC. Compared with afatinib, the PD-1 inhibitor had a better OS but a worse PFS.
Uniformly Dispersed Cu Nanoparticles over Mesoporous Silica as a Highly Selective and Recyclable Ethanol Dehydrogenation Catalyst
Authors: Hao Yan , Zhao Dajie , Liu Wen , Zhang Min , Lou Yixiao , Wang Zhenzhen , Tang Qinghu , Yang Jinghe
Published: September 2022

Selective dehydrogenation of ethanol to acetaldehyde has been considered as an important pathway to produce acetaldehyde due to the atom economy and easy separation of acetaldehyde and hydrogen. Copper catalysts have attracted much attention due to the high activity of Cu species in O-H and C-H bonds oxidative cleavage, and low process cost; however, the size of the Cu nanoparticle is difficult to control since it is easily suffers from metal sintering at high temperatures. In this work, the Cu/KIT-6 catalyst exhibited an ultra-high metal dispersion of 62.3% prepared by an electrostatic adsorption method, due to the advantages of the confinement effect of mesoporous nanostructures and the protective effect of ammonia water on Cu nanoparticles. The existence of an oxidation atmosphere had a significant effect on the valence state of copper species and enhancing moderate acid sites. The catalyst treated by reduction and then oxidation possessed a moderate/weak acid site ratio of ~0.42 and a suitable proportion of Cu+/Cu0 ratio of ~0.53, which conceivably rendered its superior ethanol conversion of 96.8% and full acetaldehyde selectivity at 250 °C. The catalyst also maintained a high selectivity of >99% to acetaldehyde upon time-on-stream of 288 h.
Recent Advances in Vehicle Exhaust Treatment with Photocatalytic Technology
Authors: Zhao Jianyong , Sun Jianpeng , Meng Xiangchao , Li Zizhen
Published: September 2022

Vehicle exhaust has been acknowledged as an essential factor affecting human health due to the extensive use of cars. Its main components include volatile organic compounds (VOCs) and nitrogen oxides (NOx), which can cause acute irritation and chronic diseases, and significant research on the treatment of vehicle exhaust has received increasing attention in recent decades. Recently, photocatalytic technology has been considered a practical approach for eliminating vehicle emissions. This review highlights the crucial role of photocatalytic technology in eliminating vehicle emissions using semiconductor catalysts. A particular emphasis has been placed on various photocatalytic materials, such as TiO2-based materials, Bi-based materials, and Metal–Organic Frameworks (MOFs), and their recent advances in the performance of VOC and NOx photodegradation. In addition, the applications of photocatalytic technology for the elimination of vehicle exhaust are presented (including photocatalysts combined with pavement surfaces, making photocatalysts into architectural coatings and photoreactors), which will offer a promising strategy for photocatalytic technology to remove vehicle exhaust.
Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis
Authors: Zhu Wenzhen , Liang Wenying , Lu Haocheng , Chang Lin , Zhang Jifeng , Chen Y. Eugene , Guo Yanhong
Published: September 2022

Genetic variants in transmembrane 6 superfamily member 2 (TM6SF2), such as E167K, are associated with atherosclerotic cardiovascular disease (ASCVD). Chronic inflammation and lipid-laden macrophage foam cell formation are the central pathogeneses in the development of atherosclerosis. This study was undertaken to illustrate the biological function of TM6SF2 in macrophages and its role during atherosclerosis development. We generated myeloid cell-specific Tm6sf2 knockout mice on ApoE-deficient background (LysM Cre+/Tm6sf2fl/fl/ApoE−/−, TM6 mKO) with littermate LysM Cre−/Tm6sf2fl/fl/ApoE−/− (Control) mice as controls. Mice were fed a Western diet for 12 weeks to induce atherosclerosis. Myeloid Tm6sf2 deficiency inhibited atherosclerosis and decreased foam cells in the plaques without changing the plasma lipid profile. RNA sequencing of bone marrow-derived macrophages (BMDMs) from TM6 mKO mice demonstrated the downregulation of genes associated with inflammation, cholesterol uptake, and endoplasmic reticulum (ER) stress. TM6SF2 was upregulated by oxidized low-density lipoprotein (oxLDL) in macrophages. Silencing TM6SF2 in THP-1-derived macrophages and Tm6sf2 deficiency in BMDMs reduced inflammatory responses and ER stress and attenuated cholesterol uptake and foam cell formation, while the overexpression of TM6SF2 showed opposite effects. In conclusion, myeloid TM6SF2 deficiency inhibits atherosclerosis development and is a potential therapeutic target for the treatment of atherogenesis.
Cell Surface Hsp90- and αMβ2 Integrin-Mediated Uptake of Bacterial Flagellins to Activate Inflammasomes by Human Macrophages
Authors: Hoang Thi Xoan , Kim Jae Young
Published: September 2022

All-trans retinoic acid (ATRA) is an active metabolite of vitamin A, which plays an important role in the immune function. Here, we demonstrated that ATRA induces the heat shock protein (Hsp) 90 complex on the surface of THP-1 macrophages, which facilitates the internalization of exogenous bacterial flagellins to activate the inflammasome response. Mass spectrometric protein identification and co-immunoprecipitation revealed that the Hsp90 homodimer interacts with both Hsp70 and αMβ2 integrin. ATRA-induced complex formation was dependent on the retinoic acid receptor (RAR)/retinoid X receptor (RXR) pathway and intracellular calcium level and was essential for triggering the internalization of bacterial flagellin, which was clathrin dependent. Notably, in this process, αMβ2 integrin was found to act as a carrier to deliver flagellin to the cytosol to activate the inflammasome, leading to caspase-1 activity and secretion of interleukin (IL)-1β. Our study provides new insights into the underlying molecular mechanism by which exogenous bacterial flagellins are delivered into host cells without a bacterial transport system, as well as the mechanism by which vitamin A contributes to enhancing the human macrophage function to detect and respond to bacterial infection.
Suppression of Hepatic PPARα in Primary Biliary Cholangitis Is Modulated by miR-155
Authors: Adamowicz Monika , Kempinska-Podhorodecka Agnieszka , Abramczyk Joanna , Banales Jesus M. , Milkiewicz Piotr , Milkiewicz Malgorzata
Published: September 2022

Background: PPARα is a ligand-activated transcription factor that shows protective effects against metabolic disorders, inflammation and apoptosis. Primary biliary cholangitis and primary sclerosing cholangitis result in the intrahepatic accumulation of bile acids that leads to liver dysfunction and damage. Small, non-coding RNAs such as miR-155 and miR-21 are associated with silencing PPARα. Methods: The expression of miR-155, miR-21 and PPARα were evaluated using real-time PCR on liver tissue, as well as on human hepatocytes (HepG2) or cholangiocytes (NHCs) following exposure to lipopolysaccharide (LPS), glycodeoxycholic acid (GCDCA), lithocholic acid (LCA) and/or ursodeoxycholic acid (UDCA). Results: A reduction of PPARα in primary biliary cholangitis (PBC) livers was associated with miR-21 and miR-155 upregulation. Experimental overexpression of either miR-155 or miR-21 inhibited PPARα in hepatocytes, whereas, in cholangiocytes, only miR-21 suppressed PPARα. Both GCDCA and LCA induced the cell type-specific upregulation of miR-155 or miR-21. In HepG2, LPS-induced miR-155 expression was blocked by a cotreatment with UDCA and was associated with PPARα upregulation. In NHC cells, the expression of miR-21 was induced by LPS but did not affect PPARα expression. Conclusions: Hepatic PPARα expression is reduced in PBC livers as a likely result of miR-155 overexpression. UDCA effectively reduced both baseline and LPS-induced miR-155 expression, thus preventing the suppression of PPARα.
Prognostic Profiling of the EMT-Associated and Immunity-Related LncRNAs in Lung Squamous Cell Carcinomas
Authors: Sun Qifeng , Gao Yan , Zhang Yehui , Cao Hongmei , Liu Jiajia , Neo Shi-Yong , Chen Keguang , Bi Yanping , Wu Jing
Published: September 2022

Lung squamous cell carcinoma (Lung SCC) is associated with metastatic disease, resulting in poor clinical prognosis and a low survival rate. The aberrant epithelial–mesenchymal transition (EMT) and long non-coding RNA (LncRNA) are critical attributors to tumor metastasis and invasiveness in Lung SCC. The present study divided lncRNAs into two subtypes, C1 and C2 (Cluster 1 and Cluster 2), according to the correlation of EMT activity within the public TCGA and GEO databases. Subsequently, the differential clinical characteristics, mutations, molecular pathways and immune cell deconvolution between C1 and C2 were evaluated. Lastly, we further identified three key lncRNAs (DNM3OS, MAGI2-AS3 and LINC01094) that were associated with EMT and, at the same time, prognostic for the clinical outcomes of Lung SCC patients. Our study may provide a new paradigm of metastasis-associated biomarkers for predicting the prognosis of Lung SCC.
7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells
Authors: Ouyang Jing , Xiao Yaosheng , Ren Qun , Huang Jishang , Zhou Qingluo , Zhang Shanshan , Li Linfu , Shi Weimei , Chen Zhixi , Wu Longhuo
Published: September 2022

7-Ketocholesterol (7KC) is one of the oxysterols produced by the auto-oxidation of cholesterol during the dysregulation of cholesterol metabolism which has been implicated in the pathological development of osteoporosis (OP). Oxiapoptophagy involving oxidative stress, autophagy, and apoptosis can be induced by 7KC. However, whether 7KC produces negative effects on MC3T3-E1 cells by stimulating oxiapoptophagy is still unclear. In the current study, 7KC was found to significantly decrease the cell viability of MC3T3-E1 cells in a concentration-dependent manner. In addition, 7KC decreased ALP staining and mineralization and down-regulated the protein expression of OPN and RUNX2, inhibiting osteogenic differentiation. 7KC significantly stimulated oxidation and induced autophagy and apoptosis in the cultured MC3T3-E1 cells. Pretreatment with the anti-oxidant acetylcysteine (NAC) could effectively decrease NOX4 and MDA production, enhance SOD activity, ameliorate the expression of autophagy-related factors, decrease apoptotic protein expression, and increase ALP, OPN, and RUNX2 expression, compromising 7KC-induced oxiapoptophagy and osteogenic differentiation inhibition in MC3T3-E1 cells. In summary, 7KC may induce oxiapoptophagy and inhibit osteogenic differentiation in the pathological development of OP.
Characterization of Three-Dimensional Trophoblast Spheroids: An Alternative Model to Study the Physiological Properties of the Placental Unit
Authors: Stojanovska Violeta , Arnold Susanne , Bauer Mario , Voss Hermann , Fest Stefan , Zenclussen Ana Claudia
Published: September 2022

It was postulated that 3D cell culture models more accurately reflect the complex tissue physiology and morphology in comparison to 2D cell monolayers. Currently, there is a shortage of well-characterized and easily maintainable high-throughput experimental models of the human placenta. Here, we characterized three different 3D cultures (e.g., spheroids) derived from trophoblast cell lines and studied their functionality in comparison to primary fetal trophoblasts and placental tissue. The spheroid growth rates of JEG3, BeWo and HTR8/SVneo cell lines were similar among each other and were significantly larger in comparison to primary trophoblast spheroids. All spheroids exhibited migratory properties and shortest distances were registered for JEG3 spheroids. Even though all spheroids displayed invasive capabilities, only the invasive features of HTR8/SVneo spheroids resulted in specific branching. This was in agreement with the invasive properties of the spheroids obtained from primary trophoblasts. Human chorionic gonadotropin production was highest in JEG3 spheroids and only increased when stimulated with cAMP and forskolin in BeWo, but not HTR8/SVneo spheroids. The gene expression analysis confirmed that 3D trophoblast cell cultures and especially HTR8/SVneo spheroids showed considerable similarities with the gene expression profile of primary placental tissue. This study offers a broad characterization of 3D trophoblast spheroids that, in turn, can help in selecting the best model depending on the scientific question that needs to be answered.
Dissociative Electron Attachment Cross Sections for Ni(CO)4, Co(CO)3NO, Cr(CO)6
Authors: Pintea Maria , Mason Nigel , Tudorovskaya Maria
Published: September 2022

Ni(CO)4, Cr(CO)6, Co(CO)3NO are some of the most common precursors used for focused electron beam induced deposition. Some of the compounds, even though extensively used have high requirements when it comes to handling being, explosives, highly flammable and with high toxicity levels, as is the case of Ni(CO)4. We are employing simulations to determine values hard to determine experimentally, and compare them with DFT calculations and experimental data where available. The use of Quantemol-N cross section simulations for dissociative electron attachment (DEA) at low electron energy in the range of 0–20 eV, gives valuable information on the fragmentation of the molecules, based on their bond dissociation energies, electron affinities and incident electron energies. The values obtained for the cross sections are 0.12 × 10−18 cm2 for Ni(CO)4, 4.5 × 10−16 cm2 for Co(CO)3NO DEA cross-sections and 4.3 × 10−15 cm2 for Cr(CO)6.
Chronic Conditions and School Participation of First-Year University Students—HOUSE ULisbon Study
Authors: Cerqueira Ana , Botelho Guedes Fábio , Marques-Pinto Alexandra , Branco Amélia , Galvão Cecília , Sousa Joana , Goulao Luis F. , Bronze Maria Rosário , Viegas Wanda , Gaspar Tania , Godeau Emmanuelle , de Matos Margarida Gaspar
Published: September 2022

Students with chronic conditions (CC) tend to experience several barriers in terms of their school participation and performance. Therefore, the present study aims to explore the factors related to the time of diagnosis of CC (recent/non-recent), the barriers to participation and academic success (health condition, people’s attitude towards CC and school physical environment), the physical and mental health (physical/psychological symptoms and concerns) and school-related variables (relationship with teachers and peers), regarding the school participation of first-year students with CC. This work is part of the HOUSE-Colégio F3 Project, University of Lisbon, which includes 1143 first-year university students from 17 Faculties and Institutes of the University of Lisbon. In this specific study, only the subsample of 207 students with CC was considered, 72.4% of which were female, aged between 18 and 54 years (M = 20.00; SD = 4.83). The results showed that students with a recent diagnosis of CC and students with school participation affected by the CC were those who presented more negative indicators regarding barriers to school participation, physical and mental health, and school-related variables. A greater impact of CC in terms of school participation was associated with having a recent diagnosis, with people’s attitude towards CC and with the health condition as barriers, with more psychological symptoms and worse relationships with teachers and peers. This is a relevant message for the organization of health services for students with CC at the beginning of their university studies, especially since they are often displaced from home and managing their health conditions alone (in many cases, for the first time).
Preliminary Effectiveness of a Strategy to Promote Healthy Lifestyle Habits in Schoolchildren
Authors: Carvajal-Carrascal Gloria , Chinchilla-Salcedo Tania Catalina , Niño-Hernández César Augusto , Sarmiento-González Paola , Ospina-Romero Angélica María , Sánchez-Herrera Beatriz
Published: September 2022

Purpose: To measure the preliminary effectiveness of a strategy to promote healthy lifestyle habits in schoolchildren, aged 6 to 12 years, living in the Andean region of Colombia, 2018–2021. Design and Methods: This is a Nursing Methodological Research, developed in phases: (1) Context and schoolchildren characterization; (2) Strategy design guided by the Whittemore and Grey criteria and the Bronfenbrenner ecological conceptual model; (3) Strategy validation with 11 experts; (4) Trial to evaluate preliminary effectiveness. We applied the strategy in seven different schools with the educational community including 955 schoolchildren between 6 and 12 years of age, 551 parents, 130 teachers and 7 members of the food staff. Results: Our health promotion strategy “Prosalud” has five components: citizenship feeding and nutrition, physical activity, and rest; environment protection, and directing one’s own life. It includes all the participants of the educational community. Conclusions: According to experts, the health promotion strategy “Prosalud” is valid to help promoting healthy lifestyle habits among schoolchildren. This strategy demonstrates its preliminary effectiveness in a group of school children from 6 to 12 years of age, their parents, teachers, and school food staff, in the Andean region of Colombia.
Simulation of Light-Trapping Characteristics of Self-Assembled Nano-Ridges in Ternary Organic Film
Authors: Li Chang , Chen Mingxin , Li Fen , Sun Xiaoxiang , Yu Zhuoliang , Tao Jiayou , Zou Zhijun , Liao Gaohua , Zhang Jianjun
Published: September 2022

The presence of self-assembled nano-ridged (SANR) structures in PTB7-Th:PC70BM:PC60BM ternary organic blend film with the specific component ratio was experimentally clarified, and the light-trapping effect of the SANR structures was demonstrated. On this basis, the light-trapping characteristics of the PTB7-Th:PC70BM:PC60BM ternary blend film with the SANR structures were investigated by using the finite-difference time-domain (FDTD) algorithm. The results showed that the SANR structures have a light-trapping effect, which can effectively reduce the transmittance and reflectance of the incident photons at the specific wavelengths and thus exhibit stronger photon absorption, especially for the photons in the wavelength range of 550–650 nm. The light-trapping effect of the SANR structures does not depend on the direction of photon incidence, and the active layer traps the photons incident from both its top and bottom. The dimensional variation of the SANR has a significant effect on the light-trapping characteristics of the active layer, and the effect caused by the height variation is overwhelmingly superior compared with that of the width variation. In addition, the higher the density of the SANR, the more significant the light-trapping effect of the active layer. This work provides a theoretical basis for the further experimental enhancement of the photon absorption capacity of the PTB7-Th:PC70BM:PC60BM active layer with SANR structures.
Graphene Nanoribbon Bending (Nanotubes): Interaction Force between QDs and Graphene
Authors: Armaghani Sahar , Rostami Ali , Mirtaheri Peyman
Published: September 2022

Carbon materials in different shapes—such as fullerene molecules (0D), nanotubes and graphene nanoribbons (1D), graphene sheets (2D), and nanodiamonds (3D)—each have distinct electrical and optical properties. All graphene-based nanostructures are expected to exhibit extraordinary electronic, thermal, and mechanical properties. Moreover, they are therefore promising candidates for a wide range of nanoscience and nanotechnology applications. In this work, we theoretically studied and analyzed how an array of quantum dots affects a charged graphene plate. To that end, the array of quantum dots was embedded on the graphene plate. Then, considering the interaction between QDs and graphene nanoribbons, we transformed the charged plate of a graphene capacitor into a nanotube using the bipolar-induced interaction and the application of an external electromagnetic field. In this work, the dimensions of the graphene plate were 40 nm × 3100 nm. The bending process of a charged graphene plate is controlled by the induced force due to the applied electromagnetic field and the electric field induced by the quantum dots. Finally, using the predetermined frequency and amplitude of the electromagnetic field, the graphene nanoribbon was converted into a graphene nanotube. Since the electrical and optical properties of nanotubes are different from those of graphene plates, this achievement has many practical potential applications in the electro-optical industry.
A Facile Way to Modify Polyester Fabric to Enhance the Adhesion Behavior to Rubber
Authors: He Hongwei , Wu Pengfeng , Yang Zeguang , Shi Zhihao , Yu Wenwen , Liu Fuyong , Zhu Fengbo , Zheng Qiang , Zhang Dezhong , Li Shumin
Published: September 2022

Due to the extremely inert surface of polyester (PET) fabric, a toxic and traditional resorcinol-formaldehyde-latex (RFL) dipping solution is always necessary in the rubber composite industry. Unfortunately, other effective methods for fabric surface treatment are in urgent need to improve the poor bonding interface between the fabric and the rubber matrix. In our study, a facile way to modify PET fabric was developed. Specifically, the fabric was treated by an alkaline solution and a coupling agent with magnetic agitation. Afterwards, the treated fabric/rubber composites were prepared through a co-vulcanization process. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermogravimetric analysis (TGA) were used to characterize the surface chemical composition of the modified fabrics. The adhesion behavior was analyzed by the peel test. The results showed that the fabric surface was successfully grafted with a coupling agent, and the peel strength reached 9.8 N/mm after KH550 treatment, which was an increase if 32% compared with that of the original fabric/rubber composite. In addition, the vulcanization rate and interfacial fracture mechanism are also researched.
Progress on Current-Carry Friction and Wear: An Overview from Measurements to Mechanism
Authors: Li Shuaibing , Yang Xingzu , Kang Yongqiang , Li Zongying , Li Hongwei
Published: September 2022

As aerospace, electrified railway, weapon equipment manufacturing, and other fields have leapt forward, the operating environment of current-carrying friction pairs is becoming increasingly severe, and research on the current-carrying friction and wear theory and its vital technologies are progressively in demand. This study summarizes the relevant research on the current-carrying friction and wear. In this study, the essential characteristics and classification of current-carrying friction and wear are summarized, the effect of working parameters on current-carrying friction and wear performance is clarified, and the generation mechanism, failure mechanism, and factors of current-carrying friction and wear are emphatically investigated. Moreover, the mechanism of arc generation and the effect of environmental conditions and surface facial masks on the friction and wear process are summarized. This paper also introduces the preparation technology of a conductive wear-resistant self-lubricating material, the main factors affecting the conductive wear-resistant property of the coating, and the action mechanism. The simulation and prediction results of the current-carrying friction and wear temperature field and the wear amount are presented. Finally, the problems in the current-carrying friction and wear research are classified, and future research directions in this field are proposed. The future’s critical development and improvement directions are also proposed from the aspects of developing coating quality evaluation equipment, optimizing the coating quality, and studying the coating self-lubricating mechanisms.
Theoretical Study of Vibrational Properties of Peptides: Force Fields in Comparison and Ab Initio Investigation
Authors: Luchetti Nicole , Minicozzi Velia
Published: September 2022

Infrared (IR) spectroscopy is a valuable tool to obtain information about protein secondary structure. The far-infrared (FIR) spectrum is characterized by a complex combination of different molecular contributions which, for small molecules, may be interpreted with the help of quantum-mechanical (QM) calculations. Unfortunately, the high computational cost of QM calculations makes them inapplicable to larger molecules, such as proteins and peptides. In this work, we present a theoretical study on the secondary structure, molecular properties, and vibrational spectra of different peptides, using both a classical and a QM approach. Our results show that the amide I main peak value, and related quantities, such as dipole strength (DS) and transition dipole moment (TDM), depends on protein secondary structure; in particular, from QM calculations arises that α-rich molecular systems present lower intensities than β-rich ones. Furthermore, it is possible to decouple and identify the intensity of the different contributions of the inter- and intra-molecular motions which characterize the FIR spectrum, starting from the results obtained with QM calculations.
Subliminal Channels in Visual Cryptography
Authors: Koptyra Katarzyna , Ogiela Marek R.
Published: September 2022

This paper describes three methods of creating a subliminal channel in visual cryptography that are defined for a (2,2) sharing scheme. They work by hiding additional covert information besides the original encrypted image. The first channel is revealed when the user folds the share along the specific axis. The second channel encodes subpixels on the basis of the encrypted message bits. It is designed to hide a wide range of data types. The third channel may be applied to a single share or multiple shares and is revealed when the proper parts of the shares are stacked. Fold and overlapping algorithms are adequate for printed shares, but the encryption method is only suitable for digital shares. The capacity of these methods ranges from half of the image size to the whole image size. The presented algorithms work on black-and-white images but are expandable to color visual cryptography. They may find applications in steganography and other data-hiding techniques. The created subliminal channels do not interfere with regular images that may still be revealed by stacking the shares. In short, this article introduces subliminal channels in visual cryptography, presents three algorithms for both binary and colorful images, shows examples of use with the results obtained, and discusses features of each method.
Connected Blockchain Federations for Sharing Electronic Health Records
Authors: Hashim Faiza , Shuaib Khaled , Sallabi Farag
Published: September 2022

With the growing utility of blockchain technology, the desire for reciprocal interactions among different blockchains is growing. However, most operational blockchain networks currently operate in a standalone setting. This fragmentation in the form of isolated blockchains creates interoperability difficulties, inhibiting the adoption of blockchains in various ecosystems. Interoperability is a key factor in the healthcare domain for sharing EHRs of patients registered in independent blockchain networks. Each blockchain network could have its own rules and regulations, obstructing the exchange of EHRs for improving diagnosis and treatments. Examples include patients being treated by healthcare providers in different countries or regions, or within one country but with a different set of rules per state or emirate. By contrast, a federation of blockchain networks can provide better communication and service to stakeholders in healthcare. Thus, solutions for facilitating inter-blockchain communication in such a blockchain federation are needed. However, this possibility has not been fully explored, and further investigations are still being conducted. Hence, the present study proposes a transaction-based smart contract triggering system for inter-blockchain communication, enabling EHR sharing among independent blockchains. We use local and global smart contracts that will be executed once a transaction is created in the blockchain. Local smart contracts are used for EHR sharing within the blockchain, whereas global smart contracts are used for EHR sharing among independent blockchains. The experimental setup is conducted using the Hyperledger Fabric blockchain platform. Inter-blockchain communication between two independent fabric networks is conducted through a global smart contract using Hyperledger Cactus for EHR sharing in a health federation setup. To the best of our knowledge, our study is the first to implement an inter-blockchain communication model in the healthcare domain.
Reaction-Time-Dependent Opto-Electrical Properties of Graphene Oxide
Authors: Kashif Muhammad , Alsaiari Norah Salem , Jaafar Erdawaty , Low Foo Wah , Oon Cheen Sean , Sahari Siti Kudnei , Almuaikel Nayef S.
Published: September 2022

The reaction-time-dependent synthesis of graphene oxide (GO) was carried out using a modified Hummer’s method. The drop-casting method was used to coat GO films on a glass substrate. Various techniques, including scanning electron microscopy, X-ray diffraction, UV–Vis spectroscopy (UV–Vis), Fourier transform infrared spectroscopy, and current–voltage characteristics, were performed to obtain the morphological, structural, optical, and electrical properties of GO. Morphological structural observations revealed that more oxygen functional groups were present as the reaction time increased from 24 to 96 h, which was confirmed by the optical properties of GO thin films. The resistivity of the as-deposited films increased from 9.74 × 106 to 26.85 × 106 Ω·cm as the reaction time increased. The optimized reaction time with a resistivity of 12.13 × 106 Ω·cm was 48 h, as demonstrated by morphological and optical data.
Theoretical Study on Freezing Separation Pressure of Clay Particles with Surface Charge Action
Authors: Liu Xiaoyan , Cheng Hua , Chen Hanqing , Guo Longhui , Fang Yu , Wang Xuesong
Published: September 2022

This study aimed to clarify the mechanism of the effect of surface charge of clay particles on the separation pressure between adjacent frozen clay particles. A general mathematical model of separation pressure between adjacent spherical clay particles was given based on the extended colloidal stability (DLVO) theory; it was introduced into the frost heave process, and the functional expression of separation pressure and freezing temperature between clay particles was derived by using the relationship between the pore throat’s radius and freezing temperature, which was verified by the existing experimental results. Finally, the effects of the freezing temperature, mineral species and solution concentration on the freezing separation pressure and ice-lens growth were analyzed. Our results show that the surface distance of adjacent charged bodies is a single-valued function of their separation pressure, but the freezing temperature is the main factor affecting the separation pressure between adjacent frozen clay particles; the separation pressure between adjacent clay particles is proportional to its surface-charge density. For the same particle spacing, the separation pressures of kaolinite and illite are not much different, but they are both about one order of magnitude lower than montmorillonite; the separation pressure between clay particles is negatively correlated with the solution concentration. When the solution concentration is less than 0.1 mol·m−3, the effect of the solution concentration on the separation pressure between particles is negligible. The research results can provide a theoretical reference for improving the existing geotechnical frost heave theory.
The Reliability of SAC305 Individual Solder Joints during Creep–Fatigue Conditions at Room Temperature
Authors: Abueed Mohammed , Al Athamneh Raed , Tanash Moayad , Hamasha Sa’d
Published: September 2022

The failure of one solder joint out of the hundreds of joints in a system compromises the reliability of the electronics assembly. Thermal cycling is a result of both creep–fatigue mechanisms working together. To better understand the failure process in thermal cycling, it is crucial to analyze both the effects of creep and fatigue mechanisms in a methodical manner. In this work, individual solder junctions are subjected to accelerated shear fatigue testing to investigate the effects of creep and fatigue on joint dependability at room temperature. A modified fixture is used to conduct fatigue tests on an Instron 5948 micromechanical tester. SAC305 joints with an OSP surface finish were cycled under stress control at first, and then the strain was maintained for a set amount of time. In this investigation, three stress amplitudes of 16, 20, and 24 MPa are used, together with varying residence periods of 0, 10, 60, and 180 s. The fatigue life of solder junctions is described for each testing condition using the two-parameter Weibull distribution. Additionally, as a function of stress amplitude and residence time, a dependability model is created. For each testing scenario, the progression of the stress–strain loops was studied. By quantifying relevant damage metrics, such as plastic work per cycle and plastic strain at various testing circumstances, the damage due to fatigue is distinguished from creep. To investigate the relationships between plastic work and plastic strain with fatigue life, the Coffin–Manson and Morrow Energy model is used. The results indicate that using greater stress magnitudes or longer dwell periods significantly shortens fatigue life and dramatically increases plastic work and plastic strain. The housing impact is significant; in some circumstances, testing with a longer dwelling period and lower stress amplitude resulted in more damage than testing with a shorter dwelling period and higher stress levels. When illustrating the fatigue behavior of solder junctions under various stress amplitudes or dwellings, the Coffin–Manson and Morrow Energy model were both useful. In the end, general reliability models are developed as functions of plastic work and plastic strain.
Acquired G2032R Resistance Mutation in ROS1 to Lorlatinib Therapy Detected with Liquid Biopsy
Authors: Jóri Balázs , Falk Markus , Hövel Iris , Weist Peggy , Tiemann Markus , Heukamp Lukas C. , Griesinger Frank
Published: September 2022

Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK)/receptor tyrosine kinase inhibitor (ROS1), demonstrated efficacy in ROS1 positive (ROS1+) non-small cell lung cancer (NSCLC), although approval is currently limited to the treatment of ALK+ patients. However, lorlatinib-induced resistance mechanisms, and its efficacy against the resistance mutation G2032R in ROS1, respectively, have not yet been fully understood. Furthermore, concomitant tumor suppressor gene p53 (TP53) mutations occur in driver alteration positive NSCLC, but their prognostic contribution in the context of ROS1 inhibition remains unclear. Here we report a ROS1+ NSCLC patient who developed an on target G2032R resistance mutation during second-line lorlatinib treatment, indicating the lack of activity of lorlatinib against ROS1 G2032R. The resistance mutation was detected in plasma-derived ctDNA, signifying the clinical utility of liquid biopsies.
Analysis of Key Factors Associated with Response to Salvage High-Dose Methotrexate Rechallenge in Primary Central Nervous System Lymphoma with First Relapse
Authors: Du Peng , Chen Hongyi , Shen Li , Liu Xiao , Wu Xuefan , Chen Lang , Cao Aihong , Geng Daoying
Published: September 2022

Background: Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin’s lymphoma that occurs in the central nervous system. Although sensitive to chemotherapy, 35–60% of PCNSL patients still relapse within 2 years after the initial treatment. High-dose methotrexate (HD-MTX) rechallenge is generally used in recurrent PCNSL, especially for patients who have achieved a response after initial methotrexate (MTX) treatment. However, the overall remission rate (ORR) of HD-MTX rechallenge is about 70–80%. Additionally, the side effects of HD-MTX treatment endanger the health of patients and affect their quality of life. Methods: This is a retrospective study of patients with first relapse PCNSL at Huashan Hospital, Fudan University between January 2000 and November 2020. By comparing the clinical characteristics and radiological manifestations of first relapsed PCNSL patients with remission and non-remission after receiving HD-MTX rechallenge, we screened out the key factors associated with HD-MTX rechallenge treatment response, to provide some help for the selection of salvage treatment strategies for patients with recurrent PCNSL. Additionally, patients with remission after HD-MTX rechallenge were followed up to identify the factors related to progression-free survival of the second time (PFS2) (time from the first relapse to second relapse/last follow-up). The Kruskal–Wallis and Pearson chi-square tests were performed to examine the univariate association. Further, multivariable logistic regression analysis was used to study the simultaneous effect of different variables. Results: A total of 207 patients were enrolled in the study based on the inclusion criteria, including 114 patients in the remission group (RG) and 81 patients in the non-remission group (nRG), and 12 patients were judged as having a stable disease. In Kruskal–Wallis and Pearson chi-square tests, progression-free survival rates for first time (PFS1) and whether the initial treatment was combined with consolidated whole brain radiotherapy (WBRT) were related to the response to HD-MTX rechallenge treatment, which was further validated in regression analysis. Further, after univariate analysis and regression analysis, KPS was related to PFS2. Conclusions: For PCNSL patients in their first relapse, HD-MTX rechallenge may be an effective salvage treatment. PFS1 and whether initial treatment was combined with consolidation WBRT were associated with HD-MTX rechallenge treatment response. In addition, patients with higher KPS at the time of the first relapse had a longer PFS2 after HD-MTX rechallenge treatment.