bluuebunny/crossref_metadata_2025 huggingface dataset:
An Insight into Mesoporous Silica Nanoparticles: Ray of Hope for Cancer
Management
Authors: Singh Chauhan Chetan , Garg Akash , Agrawal Rutvi
Published: October 2023

Cancer is one of the fatal diseases leading to a high mortality rate. The conventional formulations
available for the treatment of cancer are associated with several drawbacks. The major
ones are increased side effects due to improper tumor selectivity, metastasis of cancer cells and development
of multi-drug resistance to available chemotherapeutic drugs. The development of nanobased
formulations for the treatment of cancer has been found to be beneficial up to a great extent.
Mesoporous Silica nanoparticles are one of the nanotechnology-based formulations that could overcome
major disadvantages associated with conventional therapy, such as metastasis, multi-drug resistance
and side effects to normal cells. MSN-based nanoformulations could provide dual therapeutic
effects against cancer cells. Due to their small size and large surface, which could be functionalized
by using different targeting and therapeutic moieties, they provide targeted and enhanced drug
delivery. This review highlights Mesoporous silica nanoparticles along with their properties, drug
encapsulation and various applications in drug delivery, such as multi-targeting strategy, and multimodal
combined therapy by using ultrasound, photodynamic etc. In the future, MSN-based nanomedicines
could be used to develop other innovative strategies for cancer treatment.
A Review on Indole as a Cardinal Scaffold for Anticancer Drugs Development
Authors: Rana Meenakshi , Ranjan Rajeev , Sekhar Ghosh Niladry , Kumar Dharmendra , Singh Ranjit
Published: October 2023

Chemotherapy is the mainstay of therapeutic cancer therapy; however, the development of
resistance typically makes it less effective. There are continuous efforts by researchers to find novel
lead compounds with potent anti-cancer activity. Generally, synthetic or natural heterocyclic compounds
have been investigated in detail as a scaffold for cancer therapeutics. Among them, indole,
owing to its unique physiochemical and biological properties, provides a promising platform for the
development of pharmacophores for drug development against cancer, acting via various mechanisms.
Till now, several indole-based derivatives have been identified as anti-cancer agents, which
are either being used in clinics or are in various phases of clinical trials, suggesting their importance
in anti-cancer drug development. These anti-cancer drugs have been classified into different classes
depending on their mechanism of action. For example, histone deacetylase inhibitors (HDAC inhibitors),
silent mating type information regulation 2 homolog (SIRT) inhibitors, tubulin inhibitors,
proviral insertion site in Moloney murine leukemia virus (Pim) inhibitors, DNA Topoisomerase
inhibitors, and kinase inhibitors. In this review, the author's approach is to compile the recent
developments on indole-based anti-cancer drugs and provide insight into the respective structureactivity
relationships (SARs) of the compounds. We hope the review will provide a thorough understanding
to the reader and guide to developing novel and potent indole-based anticancer agents
against drug-sensitive and drug-resistant cancer in the future.
Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19
Authors: Zendedel Elham , Tayebi Lobat , Nikbakht Mohammad , Hasanzadeh Elham , Asadpour Shiva
Published: October 2023

Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral
disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration characteristics,
however, the exact processes are unknown. MSC therapy was found to be effective in lowering
immune system overactivation and increasing endogenous healing after SARS-CoV-2 infection
by improving the pulmonary microenvironment. Many studies on mesenchymal stem cells have been
undertaken concurrently, and we may help speed up the effectiveness of these studies by collecting
and statistically analyzing data from them. Based on clinical trial information found on clinicaltrials.
gov and on 16 November 2020, which includes 63 clinical trials in the field of patient treatment
with COVID-19 using MSCs, according to the trend of increasing studies in this field, and with the
help of meta-analysis studies, it is possible to hope that the promise of MSCs will one day be realized.
The potential therapeutic applications of MSCs for COVID-19 are investigated in this study.
The Clinical Significance and Prognostic Value of ALDH1 Expression in
Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis
Authors: Li Dong , Cao Yu , Luo Cheng-Wen , Zhang Li-ping , Zou Ying-Bo
Published: October 2023

Background:

The results of the association between aldehyde dehydrogenase 1
(ALDH1) expression and prognosis of non-small cell lung cancer (NSCLC) are contradictory. We
conducted this meta-analysis to investigate the clinical significance and prognostic value of
ALDH1 in NSCLC.

Methods:

The databases PubMed, Web of Science, EMBASE, the Cochrane Library, Wanfang,
and CNKI were systematically queried to identify eligible studies. The retrieval time was from
database establishment to August 2023. We evaluated the correlation between ALDH1 expression
and clinical features of NSCLC by employing odds ratios (ORs) and 95% confidence intervals
(95% CIs). In addition, we used hazard ratios (HRs) and 95% CIs to evaluate the role of ALDH1
expression in the prognosis of NSCLC.

Results:

Our study included 21 literatures involving 2721 patients. The expression of ALDH1 in
NSCLC was higher than that in normal tissues (OR = 6.04, 95% CI: 1.25-29.27, P = 0.026). The
expression of ALDH1 was related to TNM stage (OR = 1.81, 95% CI: 1.06-3.09, P = 0.029), tumor
grade (OR = 0.29, 95% CI: 0.17-0.48, P < 0.0001), lymph node metastasis (OR = 2.60, 95%
CI: 1.52-4.45, P = 0001) and histological subtype (OR = 0.67, 95% CI: 0.52-0.86, P = 0.002). In
patients with NSCLC, we found that the over-expression of ALDH1 was significantly associated
with poor overall survival (OS) (HR = 1.44, 95% CI: 1.15-1.81, P = 0.002) and disease-free survival
(DFS) (HR = 1.74, 95% CI: 1.45-2.10, P < 0.0001).

Conclusion:

The expression of ALDH1 is closely associated with the clinicopathologic characteristics
and prognosis of NSCLC. ALDH1 may serve as a valuable clinical assessment tool and
prognostic predictor in NSCLC.
Non-nutritive Sweeteners: Weight Loss or Weight Gain?
Authors: Khalil Sarah , Haikal Yara , Aoun Antoine
Published: October 2023

The consumption of non-nutritive sweeteners (NNS) is on the rise among different
populations. In parallel, the debate about their potential health benefits and risks remains inconclusive.
Numerous published studies elucidate the impact of NNS on general health, weight
control, and the risk of certain diseases. However, no definitive conclusions regarding the effect
of chronic NNS use on weight have been reached in humans. This review summarizes current
evidence related to the biological role of NNS and their subsequent effects on weight. The
mechanisms of action through which NNS impact weight are discussed, including their effect
on sweet taste receptors, cognition, metabolic and endocrine functions, intestinal microbiota,
and adiposity. Conflicting evidence is hindering the formulation of precise recommendations,
but the evidence opposing the use of NNS remains weak, and the ultimate impact on weight
largely relies on several other behavioral patterns.
IoT-based Ubiquitous Healthcare System with Intelligent Approach to an Epidemic
Authors: Mohapatra Subasis , Yesubabu Mannava , Sahoo Amlan , Mohanty Subhadarshini , Mohanty Sachi Nandan
Published: October 2023

Background::

The recent pandemic has shown its different shades across various solicitations, especially in the healthcare sector. It has a great impact on transforming the traditional healthcare architecture, which is based on the physical approaching model, into the modern or remote healthcare system. The remote healthcare approach is quite achievable now by utilizing multiple modern technological paradigms like AI, Cloud Computing, Feature Learning, the Internet of Things, etc. Accordingly, the pharmaceutical section is the most fascinating province to be inspected by medical experts in restoring the evolutionary healthcare approaches. COVID-19 has created chaos in the society for which many unexpected deaths occur due to delays in medication and the improper prognosis at an irreverent plan. As medical management applications have become ubiquitous in nature and technology-oriented, patient monitoring systems are getting more popular among medical actors.

Method:

The Internet of Things (IoT) has achieved the solution criteria for providing such a huge service across the globe at any time and in any place. A quite feasible and approachable framework has evolved through this work regarding hardware development and predictive patent analysis. The desired model illustrates various approaches to the development of a wearable sensor medium that will be directly attached to the body of the patients. These sensor mediums are mostly accountable for observing body parameters like blood pressure, heart rate, temperature, etc., and transmit these data to the cloud storage via various intermediate steps. The storage medium in the cloud will be storing the sensor-acquired data in a time-to-time manner for a detailed analysis. Further, the stored data will be normalized and processed across various predictive models.

Results and Conclusion:

The model with the best accuracy will be treated as the resultant model among the numerous predictive models deployed in the cloud. During the hardware development process, several hardware modules are discussed. After receiving sensor-acquired data, it will be processed by the cloud's multiple machine-learning models. Finally, thorough analytics will be developed based on a meticulous examination of the patients' cardinal, essential, and fundamental data and communicated to the appropriate physicians for action. This model will then be used for the data dissemination procedure, in which an alarm message will be issued to the appropriate authorities.
A Review of Ethnopharmacological Uses, Phytochemistry and Pharmacological Attributes of Mesua ferrea Linn.
Authors: Vijay Pahurkar Sayukta , Rikhabchand Surana Ajaykumar , Ramesh Pawar Pratiksha
Published: October 2023

Ethnopharmacological relevance: Mesua ferrea Linn. belonging to family Guttiferae.
The plant widely grows in the hills and is planted in gardens in many parts of India. It is cultivated
as an ornamental plant because of its graceful shape, pink to red hanging leaves and enormous
wonderful, fragrant white blossoms. The current review summarizes different significant,
fundamental and medicinal properties of this Indian therapeutic herb. It is known to be an evergreen
tree 20-30 m in height. Along with its elaborate utilization, entire plant has different therapeutic
values in the conventional system of drugs. The main aim of this review is to provide a
brief overview of the pharmacological, phytochemical, pharmacognostic, ethanomedical and
toxicological studies of M. ferrea. A comprehensive review of the literature was conducted using
multiple search sites such as PubMed, Google Scholar, Springer, and Science Direct, Scopus,
Web of Science, SciFinder, etc. Other literary sources include Wikipedia, ethnobotanical books,
and botanical journals. Numerous phytochemicals have been discovered and isolated from
Mesua ferrea plant parts which include xanthones, terpenoids, sterol, β-amyrin, β-sitosterol,
mesuaferrol, mesuaferrin-A, mesuaferrin B, caloxanthone C,1,8-dihydro-3-methoxy-6-
methylanthraquinone, friedelin, fats, flavanoids and betulinic acid. All of the documented pharmacological
activities, such as antioxidant and antibacterial activity, antiarthritic, antiinflammatory,
antivenom, antiulcerogenic, anticonvulsant, wound healing, depressant, analgesic
are due to the presence of certain phytochemical substances. This review mainly targets the botanical
aspects of Mesua ferrea along with their phytochemical constituents, ethnomedicinal use,
different pharmacological activity, and future possibilities. Mesua ferrea is very important in the
traditional Indian system. More research is needed to uncover important features of Mesua ferrea
in medical practice.
SAR Target Recognition Method based on Adaptive Weighted Decision
Fusion of Deep Features
Authors: Su Xiaoguang
Published: October 2023

Background:

This paper proposes a synthetic aperture radar (SAR) target recognition
method based on adaptive weighted decision fusion of multi-level deep features.

Methods:

The trained ResNet-18 is employed to extract multi-level deep features from SAR
images. Afterwards, based on the joint sparse representation (JSR) model, the multi-level deep
features are represented to obtain the corresponding reconstruction error vectors. Considering
the differences in the abilities of different levels of features to distinguish the target, the reconstruction
error vectors are analyzed based on entropy theory, and their corresponding weights
are adaptively obtained. Finally, the fused reconstruction error result is obtained through adaptively
weighted fusion, and the target label is determined accordingly.

Results:

Experiments are conducted on the Moving and Stationary Target Acquisition and
Recognition (MSTAR) dataset under different conditions, and the proposed method is compared
with published methods, including multi-feature decision fusion, JSR-based decision fusion and
other types of ResNets.

Conclusion:

The experimental results under standard operating condition (SOC) and extended
operating conditions (EOCs) including depression angle variance and noise corruption validate
the advantages of the proposed method.
Validation of Bioprinting Technique for Skin Equivalent Models
Authors: Brand Luiza Meurer , Lamers Marcelo Lazzaron , Matte Bibiana Franzen
Published: October 2023

Background:

Skin pigmentation is a complex process; thus, skin equivalent methodologies
that can reproduce the main skin structures and pigmentation have been studied. To improve
the skin equivalent model, bioprinting technology has emerged, allowing for the reproduction of
the complex, functional, and personalized three-dimensional architecture of the skin.

Objective:

Our aim was to develop a skin equivalent model and a pigmented skin equivalent model
and compare the manually produced models with the bioprinted models.

Methods:

The study was conducted using fibroblasts, keratinocytes, and melanocytes cell lines with
a 3D cell culture technique, either through bioprinting or manual production. Additionally, the
bleaching potential of the model was evaluated by applying kojic acid.

Results:

It was observed that the bioprinted skin equivalent model demonstrated similar cell architecture
and gene expression compared to the manually produced model. A pigmented skin equivalent
model was developed and also bioprinted. The pigmented bioprinted skin equivalent model
exhibited similar pigmentation behavior and lightening potential as the manual model.

Conclusion:

We have validated the use of bioprinting for reproducing skin equivalent model and
cost-effective scaling of skin production.
More Widespread use of Ivermectin for the Treatment of COVID-19
Infection could have Saved Many
Authors: Boretti Alberto , Banik Bimal K.
Published: October 2023

Here we review the available literature for the specific use of Ivermectin against COVID-19 infection. Currently, 204 works have been published presenting the results of ivermectin use for COVID-19. 156 are peer-reviewed, and 96 are comparing treatment and control groups. Ivermectin was adopted for early treatment in all or part of 22 countries (39 including non-government medical organizations). The 96 studies of Ivermectin for COVID-19 were published by 1,030 scientists, reporting the cases of 135,554 patients in 27 countries. These studies show a statistically significant improvement in mortality, ventilation, ICU, hospitalization, recovery, cases, and viral clearance. Specifically, improvements recorded were 85%, 62%, and 43% for prophylaxis, early, and late treatment, with confidence intervals (CI) [77-90%], [51-70%], [28-54%] respectively. A 56% improvement was recorded in the 45 randomized controlled trials (RCTs) with CI [41-68%]. A 51% lower mortality was evidenced from 49 studies with CI [37-61%]. In February 2021, when the war on Ivermectin started in the West, it was clear that this drug had positive effects, working in-vivo/in-vitro, and delivering mostly positive results in clinical trials. More widespread use of Ivermectin could have saved many people, and suppression of this drug in many countries that had very high cumulative fatalities per million people has been a very unfortunate occurrence for science.
Techniques for Recycling and Recovery of Perovskites Solar Cells
Authors: Josh S.
Published: October 2023

Perovskite-based photovoltaic cells (PSCs) have been viewed as a capable future generation candidate for photovoltaic innovation with a phenomenal improvement in power transformation productivity (PCE) because of various changes taking place over a decade due to the amazing optoelectronic qualities of perovskite materials. PSCs are extremely competitive in comparison to existing marketed silicon and thin film-based photovoltaic automation due to their configurable band gap, intense inclusion, high power transformation effectiveness, and minimal expense. Contrarily, commercial items invariably affect massive quantities of waste and the quality of products, both of which have a terrible impact on the environment. Perovskite solar cell recycling and recovery methods should be investigated and developed ahead of time to overcome this issue. As a result; PSC components must be recycled for industrial fabrication applications. The importance of recycling and several recycling approaches are discussed in this paper, along with the recycling of several parts of perovskite solar cells which include transparent conductive oxide (TCO) substrates, electron transport materials (ETM), metal electrodes, toxic lead material, and monolithic structure. The reusing technique has also been deliberated about the variety of layered designs. Lastly, the prospect of next-stage perovskite-photovoltaics reusing has been proposed as a means of encouraging eco-friendly extensive manufacture and use.
Using Transformer-Based Topic Modeling to Examine Discussions of Delta-8 Tetrahydrocannabinol: Content Analysis
Authors: Smith Brandi Patrice , Hoots Brooke , DePadilla Lara , Roehler Douglas R , Holland Kristin M , Bowen Daniel A , Sumner Steven A
Published: October 2023

Background

Delta-8 tetrahydrocannabinol (THC) is a psychoactive cannabinoid found in small amounts naturally in the cannabis plant; it can also be synthetically produced in larger quantities from hemp-derived cannabidiol. Most states permit the sale of hemp and hemp-derived cannabidiol products; thus, hemp-derived delta-8 THC products have become widely available in many state hemp marketplaces, even where delta-9 THC, the most prominently occurring THC isomer in cannabis, is not currently legal. Health concerns related to the processing of delta-8 THC products and their psychoactive effects remain understudied.

Objective

The goal of this study is to implement a novel topic modeling approach based on transformers, a state-of-the-art natural language processing architecture, to identify and describe emerging trends and topics of discussion about delta-8 THC from social media discourse, including potential symptoms and adverse health outcomes experienced by people using delta-8 THC products.

Methods

Posts from January 2008 to December 2021 discussing delta-8 THC were isolated from cannabis-related drug forums on Reddit (Reddit Inc), a social media platform that hosts the largest web-based drug forums worldwide. Unsupervised topic modeling with state-of-the-art transformer-based models was used to cluster posts into topics and assign labels describing the kinds of issues being discussed with respect to delta-8 THC. Results were then validated by human subject matter experts.

Results

There were 41,191 delta-8 THC posts identified and 81 topics isolated, the most prevalent being (1) discussion of specific brands or products, (2) comparison of delta-8 THC to other hemp-derived cannabinoids, and (3) safety warnings. About 5% (n=1220) of posts from the resulting topics included content discussing health-related symptoms such as anxiety, sleep disturbance, and breathing problems. Until 2020, Reddit posts contained fewer than 10 mentions of delta-8-THC for every 100,000 cannabis posts annually. However, in 2020, these rates increased by 13 times the 2019 rate (to 99.2 mentions per 100,000 cannabis posts) and continued to increase into 2021 (349.5 mentions per 100,000 cannabis posts).

Conclusions

Our study provides insights into emerging public health concerns around delta-8 THC, a novel substance about which little is known. Furthermore, we demonstrate the use of transformer-based unsupervised learning approaches to derive intelligible topics from highly unstructured discussions of delta-8 THC, which may help improve the timeliness of identification of emerging health concerns related to new substances.
Decoding Mediverse : Unveiling the Diagnostic Accuracy of a Medical AI Symptom Checker (DMAIS study) (Preprint)
Authors: Yap Amanda Qiao Ying , Wong Kien How , Lai Nai Ming , Lim Ze Shun , Win Min Thein , Hassan Khairul Nizam , Pala Nursaleha , Elliza Siti Alia , Bahari Rashidah
Published: October 2023

BACKGROUND

Artificial intelligence is rapidly gaining traction in healthcare. Mediverse, an AI-symptom checker constructed using medical knowledge database, predictive algorithm, Bayesian inference, feedback loop and clinical validation, aimed to aid in the initial diagnosis and provide indications for referral for patients with common symptoms, thereby improving efficiency of triaging and diagnostic process with concurrent patient education.

OBJECTIVE

We conducted a study on the Mediverse AI Symptom Checker to assess its concordance rate with the diagnoses formulated by the physicians. Additionally, we assessed patients' and doctors' satisfaction with the system's patient education on diseases. User-friendliness and acceptance levels of the system were also evaluated among both patients and doctors.

METHODS

This is a prospective validation study. Patients presenting to both outpatient clinic and emergency department of Hospital Putrajaya, Malaysia, covering study period from 1st of January 2023 to 31st March 2023, were first assessed and treated by doctors. They were then given access to Mediverse AI symptom checker to key in their main presenting symptoms. Diagnosis accuracy was evaluated by comparing the AI generated diagnosis with the diagnosis of the treating doctor. An independent assessor evaluated the concordance of the diagnosis offered by Mediverse AI symptom checker and the doctor’s diagnosis and classified the results as “complete match” (the exact same diagnosis), “partial match” (not the exact same diagnosis but a similar diagnosis that would result in the same management strategy) and “mismatch” (different category of diagnosis that would result in a different management strategy). User’s satisfaction was also evaluated.

RESULTS

The study involved 75 doctors and 325 patients from general outpatient clinic and emergency department. In 90.5% of the encounters, the top three diagnoses offered by Mediverse AI symptom checker matched the doctor’s diagnosis, with 87.3% of complete match or partial match. Among the participating doctors, the majority (n=180, 55.4%) strongly agreed that the triage advice provided by the Mediverse AI symptom checker for each diagnosis was appropriate.

CONCLUSIONS

The Mediverse AI symptom checker demonstrates promise as a tool for assisting initial diagnosis, exhibiting a high level of concordance with human diagnosis and receiving a high user satisfaction rate. Further research is warranted to assess its effectiveness in a diverse patient population encompassing a wide range of symptoms and conditions.

CLINICALTRIAL

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The Impact of Vocabulary Assessment and Personalized Feedback on Students’ Vocabulary Mastery
Authors: Fengyu Zai
Published: October 2023

This review explores the synergy between vocabulary assessment and personalized feedback in supporting students’ vocabulary mastery and enhancing their learning experiences. Vocabulary plays a crucial role in academic success, serving as the cornerstone of comprehension and communication. Therefore, accurate vocabulary assessment and effective feedback mechanisms are imperative. The paper outlines the significance of individualized learning, emphasizing the need to recognize students’ unique learning styles and tailor feedback accordingly, and discusses the transformative role of technology in facilitating innovative assessment and feedback approaches. However, the implementation of these approaches encounters various challenges, including technical barriers, logistical hurdles, and resistance from educators and students. The current body of research, while insightful, also presents limitations such as restricted scope, scale, and unaddressed gaps in knowledge. Despite these challenges, the integration of vocabulary assessment and personalized feedback offers promising prospects for enhancing students’ learning outcomes and motivation. Future research needs to focus on overcoming existing challenges and expanding the understanding of this integrative educational approach to benefit diverse student populations.
Yield Modeling of Okra (Abelmoschus esculentus L. moench) in Bituminous Soils of Southern Ondo State, Nigeria
Authors: Bimpe Imoukhuede Oladunni , Toyin Fasinmirin Johnson , Moses Olayanju Gbenga
Published: October 2023

This study investigated the growth and yield response of okra (Abelmoschus esculentus L. Moench) in bituminous soils of selected communities (Loda, Lofo and Legbogbo) in Irele, southern Ondo State for two consecutive growing seasons (2020 and 2021). The Legbogbo site, which of very low bitumen, serves as the control. The textural class is sandy loam and the soil is acidic. Some samples of soil were collected from three dug soil profile pit at depths 0-100 cm at an interval of 10 cm and moved to the soil laboratory for the analysis of the chemical concentrations of macro and trace elements. The highest value of the heavy metal was recorded at Loda. More so, the least amount of the bitumen concentration was recorded at Legbogbo site (control) and in some cases at Lofo site. Result from the study showed that there is significant difference (P < 0.05) in the values of the heavy metals among the location at all depths. The results from various locations also showed that the soil depth and location were significant (P < 0.05) in their main effects on the soil heavy metals. It was observed that the heavy metal concentration of soil was lower than the permissible limit, an indication that the concentration of heavy metals of the study areas may not have negatively influenced the growth and yield of okra. All agronomic parameters in all locations during the two seasons of experiment were in the way of Legbogbo>Lofo>Loda. Okra had 0 kg.ha-1 pod yield at the Loda site at both 2020 and 2021 growing seasons, while Legbogbo had the greatest fruit yield for both seasons. Okra yield prediction model was developed using the stepwise regression model and it was observed that Okra yield significantly correlated to potassium (r2 = 0.95) at P < 0.05 and phosphorus (r2 = 0.99) (P < 0.01).
Formulation and Evaluation of Floating in Situ Gel Based Gastro Retentive Drug Delivery of Cimetidine
Authors: Damodhar Vijay Kumar , Pinjari Rukhsana Mahiboob
Published: October 2023

In this study, we formulate and evaluate an in-situ gel of cimetidine using sodium alginate and pectin. CaCO3 was employed as a cross-linking agent, while sodium alginate and pectin were used as polymers. The polymeric formulations used in in-situ gelation drug delivery systems are in sol form before injection in the body but form a gel in the body. Drug release is maintained and regulated thanks to the composition of the gel depending on elements such as temperature modulation, pH variations, the presence of ions, and ultra-violet irradiation. This research aimed to create a unique in-situ gel system for continuous medication administration by using biodegradable polymers found in nature. Polymers that undergo a sol-to-gel phase transition when certain physicochemical conditions are altered are used in this system. At a pH appropriate for life, an in-situ gel developed. Spectrophotometric analysis of the total quantity of drug release was performed during in vitro release investigations in gastric fluid models. The formulation with 1.2% sodium alginate and 1.5% pectin was able to regulate the release of the medicine for a longer period of time, as shown in a well-planned series of studies. Viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability, water absorption capacity, and sustained drug release were all characteristics of the in-situ gel that were consistent with expectations. The in-situ gels use a fickian diffusion mechanism to release the drugs.
Strategies for Peer Teaching to Promote Collaborative Skills in Primary and Junior High School Students
Authors: Ge Mengjun
Published: October 2023

"Practice, active exploration, and cooperative exchange should be an important way for students to learn knowledge", which is the latest requirement of the New Curriculum Standard, and is an indispensable factor for students to adapt to society in the future and gain a foothold in society. Through peer teaching, students will be guided to work together gradually according to the physical and mental characteristics of primary and secondary school students. They will exchange various ways of thinking and exploring in the process of peer education, and through interaction, cultivate their thinking ability, raise their awareness of collaboration, and enhance their ability to collaborate. Students will learn how to work together and take the initiative to work together to meet the demands of our era and our society.
La opresión de clase, sexo y raza a través de los relatos: Peregrinaciones de una paria, de Flora Tristán, y Aves sin nido, de Clorinda Matto
Authors: Hernández-Orozco Naomi Yoko
Published: October 2023

Para acercarse al pensamiento crítico de mujeres activistas del siglo XIX en América Latina, en torno a tres opresiones estructurales: de clase, de sexo y de raza, se propone realizar un análisis apoyado en categorías narratológicas de dos relatos de pensadoras peruanas. El primero es la autobiografía de Flora Tristán, Peregrinaciones de una paria (1837); el segundo, es la novela social de Clorinda Matto, Aves sin nido (1889). La reflexión está situada en la vida de las mujeres trabajadoras, indígenas y mestizas, pertenecientes a dos formaciones histórico sociales diferentes en la periferia mundial. Del primer relato se presenta a las actoras narrativas, las rabonas, pertenecientes a una comunidad urbana. Del segundo relato, se toma a Marcela y a Margarita, habitantes de una comunidad campesina en la sierra peruana. Aunque estas dos formaciones son diferentes, tienen en común que están sometidas estructuralmente a las tres opresiones, las cuales, en colusión, hacen de la vida humana una experiencia lacerante.
Publicidad política televisiva y estereotipos de género en elecciones intermedias
Authors: Cruz Valencia Ulises , Torres Rodríguez Ignacio Daniel , De los Santos García Carlos Armando
Published: October 2023

El presente artículo presenta un estudio que aplica la Teoría Funcional del Discurso Político en Campaña para responder a la pregunta: ¿en el spot político emitido en elecciones intermedias, de qué manera el estereotipo de género afecta la forma en cómo se ejercen las funciones del discurso sobre los temas en campaña? Mediante un análisis de contenido cuantitativo, se encontró la prevalencia de comportamientos estereotipados, al ser las candidatas quienes más aclamaciones y menos ataques registraron. Al comparar a ganadoras versus perdedoras, se observó que las primeras apelan con mayor frecuencia a habilidades de liderazgo, lo que develó un comportamiento contra-estereotipado
Candidatas y alcaldesas en las elecciones de los municipios de Campeche, 1997-2021
Authors: Martiñón Velázquez Manuel
Published: October 2023

Las elecciones de 2021 en Campeche propiciaron el cambio partidista, el arribo de la alternancia a la gubernatura y un congreso dominado por dos partidos minoritarios. A escala local, se alcanzó la representación paritaria de hombres y mujeres en las presidencias municipales, gracias a las reformas electorales de 2014 y 2019. Esto último es el interés principal de este artículo, por lo cual brinda un análisis longitudinal y descriptivo de las ocasiones en las que se postularon y eligieron candidatas. Y a partir de ello, es posible dilucidar los condicionamientos y cambios experimentados por la representación política de las mujeres desde 1997
Derecho Agrario Volumen II
Authors: Duarte Calzadias Tayde
Published: October 2023

La guía consta de cuatro unidades divididas en dos tomos, que te introducirán al estudio del derecho agrario, con la conceptualización y definición de la materia, estudio y análisis del régimen jurídico de la propiedad contenida en el artículo 27 constitucional y sus efectos jurídicos con las reformas del 6 de enero de 1992, con la formación de órganos administrativos para la procuración e impartición de la justicia agraria y la garantía de seguridad jurídica en la tenencia de la tierra.
Formación médica y escenario sociopolítico contingente: experiencia a propósito de un proceso constituyente nacional
Authors: Villalón-Calderón Marcelo Alfredo , Cerda-Thomas Rodrigo Alberto , Romero-Barrientos Aura Constanza
Published: October 2023

Introducción: El proceso de cambio constitucional chileno propició una instancia de reflexión y discusión desde una perspectiva profesional y ciudadana entre los residentes del Programa de Formación de Médicos Especialistas en Salud Pública (PFMESP) de la Universidad de Chile.

Seminario: Se realizó un seminario sobre este proceso, ideado por los residentes y guiado por el responsable del comité académico del PFMESP, dada la estrecha relación entre los marcos normativos y el quehacer de los médicos especialistas en salud pública (MESP). Las temáticas seleccionadas abarcaron aspectos conceptuales sobre normas constitucionales, su relación con la salud, contenidos específicos de la propuesta de nueva constitución (NC) y perspectivas de futuro. Se dio especial relevancia al establecimiento del diálogo constructivo, evitando la confrontación inorgánica.

Formación médica y contingencia sociopolítica: El seminario puede considerarse como un ejercicio de integración de elementos de pertinencia social en la formación médica, aspecto valorado en los procesos de acreditación de los programas de formación y del rol de la Universidad. Como parte de esta experiencia se espera que emerjan competencias deseables como la responsabilidad social, la ciudadanía profesional y el liderazgo. La formación en el ejercicio de estas supone estimular el pensamiento crítico, que aproxima de forma reflexiva la contingencia sociopolítica a las dimensiones individual y pública de la práctica de la profesión.

Aprendizajes y discusión: Se logró contactar aspectos del escenario social y político contingente con saberes específicos de los MESP. Se pusieron en práctica habilidades de liderazgo, trabajo en equipo y de diálogo profesional interpares. Finalmente, quedan planteadas temáticas y preguntas que cuestionan los modelos de desarrollo de las naciones, la valoración de la vida y salud de sus comunidades y su traducción en diversos cuerpos normativos.
Editorial
Authors: Flores Trejo Fernando Guadalupe
Published: October 2023

Me resulta muy grato dirigirme a ustedes, los autores y  las autoras de artículos jurídicos, a los y las estudiantes de la ciencia jurídica, así como a nuestros asiduos lectores y lectoras de esta Revista del Posgrado en Derecho, ya que serán objeto de publicación, valiosos ensayos jurídicos, así como interesantes entrevistas y una nueva aportación, consistente en la publicación de capítulos de tesis de grado.
Entrevista al Dr. Ariel Montoya Inostroza
Authors: Ramírez Espinoza Martha Aurora
Published: October 2023

Ariel Montoya Inostroza es abogado de la Universidad Adolfo Ibáñez y Máster in Business Administration in Fashion Business&Law del Centro de Estudios Garrigues, España. Actualmente, a través de Montoya & Viera se dedica a la consultoría Legal de PYMES y Startups con presencia en Chile y en otros países de Latinoamérica, desarrollando un sistema legal de prevención, que considera la legalidad desde el Diseño de los modelos de negocios.
Armonización del Sistema del Servicio Profesional de Carrera en la Administración Pública Centralizada en México con Ejes y Principios Rectores del Servicio Civil
Authors: Rojas Arévalo Ricardo
Published: October 2023

De acuerdo con Dussauge, existen cuatro beneficios que brinda la implementación del Servicio Profesional de Carrera; por un lado, se trata de un mecanismo que busca limitar la politización de las instituciones administrativas del Estado mexicano, es decir, el servicio profesional de carrera permite identificar los puestos públicos de carácter netamente políticos que se brindan con base en el sistema de motín y lealtad partidista, de aquellos puestos administrativos que se deben ocupar con base en el mérito y por medio de concursos abiertos. Lo anterior, permitirá que la función administrativa del Estado sea autónoma y efectiva, pero sobre todo despolitizada permitiendo una mejora en los servicios que se brindan a la ciudadanía
Ley Federal de Responsabilidad Patrimonial del Estado
Authors: Del Estado Ley Federal de Responsabilidad Patrimonial
Published: October 2023

Esta sección de la Revista, se dedica a integrar bloques nor- mativos, de instituciones jurídicas de trascendencia social, partiendo de su previsión constitucional, su regulación normativa y los criterios emitidos por el Poder Judicial Federal. Iniciamos con la Responsabilidad Patrimonial del Estado.La Responsabilidad Patrimonial del Estado, cuenta con sus primeros antecedentes en las Leyes de Reclamaciones de 1885, 1911 y 1917. En el 1994 el Código Civil Federal contemplo la responsabilidad subsidiaria del Estado.
Nociones de evolución para discusiones bio-éticas
Authors: Noguera Solano Ricardo , Rodríguez Caso Juan Manuel
Published: October 2023

Este escrito nos invita a pensar la moralidad no sólo desde la filosofía o la biología, sino también desde la historia. Así, la propuesta es mirar la moralidad desde un punto de vista evolucionista, con bases biológicas y culturales, sin olvidar las nociones filosóficas que subyacen este pensamiento.
Plomo o filosofía. Entrenar para la desinserción social en prisión
Authors: Barrientos Rastrojo José
Published: October 2023

El objetivo de Plomo o Filosofía. Entrenar para la desinserción social en prisión es dar cuenta del trabajo realizado por el proyecto BOECIO, iniciado hace algunos años, de otorgar talleres filosóficos para personas privadas de su libertad en varias prisiones iberoamericanas. Una labor que se ha extendido con el tiempo y, actualmente, tiene lugar en media docena de países e incluye a cerca de un millar de personas. El autor de este volumen y fundador de BOECIO, José Barrientos, presenta un texto dividido en cuatro bloques que pretenden introducir al lector en la Filosofía Aplicada y Experiencial, la realidad carcelaria, los estudios cuantitativos y cualitativos, los planteamientos teóricos detrás del Proyecto BOECIO y, finamente, su aplicación práctica. Así, la obra está pensada para todos aquellos que deseen iniciarse en el trabajo filosófico en prisiones (ya sea con presos, familiares, personas de seguridad o directivos), e incluso con otros grupos sociales, o que sencillamente estén interesados en el tema: filósofos, psicólogos, pedagogos, trabajadores y educadores sociales, juristas, empleados de seguridad y antropólogos, entre otros."
Method of computational models of resistance for reinforced concrete
Authors: Kolchunov Vladimir I.
Published: October 2023

Based on a comprehensive analysis of the experimental studies from the standpoint of their convergence with the theoretical solutions, the computational models of resistance (CMR) of reinforced concrete are proposed. These models include CMR1 - modeling of normal cracks, CMR2 - modeling of inclined cracks, CMR3 - modeling of diagonal cracks, CMR4 - modeling of intersecting cracks in the wall, CMR4* - modeling of cracks in a flat slab, and CMR5 - modeling of spatial cracks in torsion with bending, CMR5* - modeling of spatial cracks in bending with transverse force. Also, a hierarchy of computational models of the second and third levels is proposed. The distribution of intensity of working reinforcement along the cross-section of the calculated element was obtained in an analytical form by creating closed equations of blocks, corresponding to the blocks of the reinforced concrete element under the condition of equality to zero of partial derivatives of the Lagrange function to determine the maximum crack opening width. It is considered the effect proposed by the author on the additional deformation impact of the reaction “concrete - reinforcement” from the discontinuity of concrete during the formation of the crack by means of a special model of the two-cantilever element of fracture mechanics. Hypotheses about the distribution of linear and angular deformations during cross-section with account of gradients of deformations caused by formation of cracks were formulated for a complex-stressed element subjected to torsion with bending. Crack opening is defined as mutual displacements of reinforcement and concrete, taking into account deformation. The consolidation of substructures in the building system is performed by the method of initial parameters.
Compaction of the snow base of Vostok station wintering complex
Authors: Pashchenko Fedor A. , Kharkov Nikita S. , Sidorenko Alexander A. , Garbuzov Valery V.
Published: October 2023

The compaction of the snow base of the wintering complex under construction of the Russian Antarctic station “Vostok” is considered, which was required due to the unsuitability of the natural snow base for the perception of loads from the supports of the foundation of the wintering complex. Technical solutions were developed for snow base compaction on the basis of heating by solar radiation with the use of thermal mat and on the basis of snow vacuuming. The computational justification of the developed technical solutions was performed, which was carried out based on spatial finite element models using the computational software complex ANSYS. In this case, to substantiate the method of snow base compaction by solar radiation heating with the use of thermal mat, the calculated volume was analyzed, including the snow base zone, thermal mat and the space filled with air. When substantiating the method of snow base compaction by snow vacuuming, there was explored the calculation area for modeling the method of vacuuming for the hermetic volume of the excavation pit with immersed columns under the wintering complex foundation supports. The results of the of the calculated research have fully confirmed the assumptions laid down in the technical solutions for compaction of the wintering complex snow base by using of thermal mat and snow vacuuming.
Physical and mathematical modeling of frost resistance for cement concretes
Authors: Dobshits Lev M.
Published: October 2023

The key factor of engineering structures made of concrete and reinforced concrete is insufficient frost resistance of concretes. It is important to identify the causes and prevent concrete damage caused by frost. The research provides the basic points of the developed physical and mathematical theory of cement concretes frost resistance. Under consideration are the processes occurring during cyclic freezing and thawing of concrete in a water-saturated state. The results of the performed theoretical and experimental studies are presented. The criterion of concrete frost resistance, which estimates the pore structure of concrete, was derived on the basis of the obtained results. The suggested criterion has a close correlative relation with the frost resistance of concrete. Using this interrelation, the method was proposed for accelerated determination of actual frost resistance of concrete, as well as the method of selection concretes' compositions for a specified design frost resistance of concretes. The methods of accelerated determination of concrete frost resistance, as well as ways to increase it, are described. The developed physical and mathematical model was used to carry out computational modeling for freezing of an extended concrete structure. This made it possible to determine the changes in humidity, temperature, and pressure in concrete during cyclic freezing and thawing at different distances from the surface of its freezing and also draw graphs of changes in these parameters. The recommendations on assignment of concrete design grades by frost resistance for various elements of concrete and reinforced concrete structures are given.
Reinforcement of columns using different composite materials
Authors: Okolnikova Galina E. , Strashnova Svetlana B. , Mabhena Sikhanyisiwe Mercy , Strashnov Stanislav V.
Published: October 2023

The adoption in construction of composite materials made by combining two or more materials to produce a material with improved properties over the separate components has been steadily increasing over the past decades. In the past few years there have been advances in composite manufacturing technology, increased demand for sustainable and eco-friendly building materials, and the need for materials that are lightweight and easy for transportation. For these reason, architects and civil engineers incorporate composites into structural elements to achieve these desired goals and optimize the cost of construction. One of the most common composite materials that was introduced to the industry is fiber reinforced polymer (FRP), produced by combining fibers (carbon, glass, or aramid) with a polymer matrix (epoxy or polyester). FRP materials are lightweight, durable and corrosion resistant, which makes them ideal for use in a wide range of construction applications. This study aims to propose a comparison between four different methods as a viable solution to strengthen and reinforce column structures. The structural behavior of three different composite materials was investigated. One traditional concrete-steel column was tested in the experiment for comparison. The other three columns were reinforced using carbon fiber reinforced plastic (CFRP), glass fiber reinforced plastic (GFRP) and stainless steel respectively. The obtained experimental results were analyzed, and comparison of three different systems of reinforcement for strengthening columns with composite materials was performed.