bluuebunny/crossref_metadata_2025 huggingface dataset:
A Fine-Grained Simulation Study on the Incidence Rate of Dysentery in Chongqing, China
Authors: Hao Jian , Shen Jingwei
Published: November 2023

Dysentery is still a serious global public health problem. In Chongqing, China, there were 37,140 reported cases of dysentery from 2015 to 2021. However, previous research has relied on statistical data of dysentery incidence rate data based on administrative regions, while grained scale products are lacking. Thus, an initialized gradient-boosted decision trees (IGBDT) hybrid machine learning model was constructed to fill this gap in grained scale products. Socioeconomic factors, meteorological factors, topographic factors, and air quality factors were used as inputs of the IGBDT to map the statistical dysentery incidence rate data of Chongqing, China, from 2015 to 2021 on the grid scale. Then, dysentery incidence rate grained scale products (1 km) were generated. The products were evaluated using the total incidence of Chongqing and its districts, with resulting R2 values of 0.7369 and 0.5439, indicating the suitable prediction performance of the model. The importance and correlation of factors related to the dysentery incidence rate were investigated. The results showed that socioeconomic factors had the main impact (43.32%) on the dysentery incidence rate, followed by meteorological factors (33.47%). The Nighttime light, normalized difference vegetation index, and maximum temperature showed negative correlations, while the population, minimum and mean temperature, precipitation, and relative humidity showed positive correlations. The impacts of topographic factors and air quality factors were relatively weak.
Linear Dichroism Measurements for the Study of Protein-DNA Interactions
Authors: Takahashi Masayuki , Norden Bengt
Published: November 2023

Linear dichroism (LD) is a differential polarized light absorption spectroscopy used for studying filamentous molecules such as DNA and protein filaments. In this study, we review the applications of LD for the analysis of DNA-protein interactions. LD signals can be measured in a solution by aligning the sample using flow-induced shear force or a strong electric field. The signal generated is related to the local orientation of chromophores, such as DNA bases, relative to the filament axis. LD can thus assess the tilt and roll of DNA bases and distinguish intercalating from groove-binding ligands. The intensity of the LD signal depends upon the degree of macroscopic orientation. Therefore, DNA shortening and bending can be detected by a decrease in LD signal intensity. As examples of LD applications, we present a kinetic study of DNA digestion by restriction enzymes and structural analyses of homologous recombination intermediates, i.e., RecA and Rad51 recombinase complexes with single-stranded DNA. LD shows that the DNA bases in these complexes are preferentially oriented perpendicular to the filament axis only in the presence of activators, suggesting the importance of organized base orientation for the reaction. LD measurements detect DNA bending by the CRP transcription activator protein, as well as by the UvrB DNA repair protein. LD can thus provide information about the structures of protein-DNA complexes under various conditions and in real time.
Rheological and Aging Characteristics of Polymer-Modified Asphalt with the Addition of Sulfur
Authors: Rodrigues Ana Luiza , Falcão Caio , Williams R. Christopher
Published: November 2023

Crosslinking agents, notably sulfur, are used in asphalt binder modification to facilitate chemical bonding between polymer chains and the asphalt binder. Despite some prior research indicating the benefits of sulfur crosslinking in enhancing polymer-modified asphalt’s (PMA) stability, there is a lack of comprehensive understanding regarding its impact on rheological properties and its anti-aging potential. This study addresses these gaps by thoroughly investigating the effects of varying the sulfur content (ranging from 0.03% to 0.5% by total weight of binder) on PMA’s rheological properties. The research assesses the effectiveness of sulfur in enhancing PMA’s resistance to aging using various methods, including the Glover-Rowe parameter, FTIR analysis, and the examination of the dynamic modulus and phase angle master curves. The results indicated that the addition of sulfur, particularly up to 0.3%, bumps the high-temperature performance grade by one level, and significantly improves elasticity, allowing the PMA to support heavier traffic without experiencing rutting, all while maintaining resistance to low-temperature cracking. Furthermore, PMA with sulfur demonstrated an increase in resistance to aging, reducing the aging potential by approximately 15% with the best sulfur formulation. This enhanced durability can reduce the frequency of maintenance activities, leading to cost savings, reduced roadwork emissions, and prolonged pavement life.
Thermochemistry, Structure, and Optical Properties of a New β-La2(SO4)3 Polymorphic Modification
Authors: Basova Sofia A. , Molokeev Maxim S. , Oreshonkov Aleksandr S. , Zhernakov Maksim A. , Khritokhin Nikolay A. , Aleksandrovsky Aleksandr S. , Krylov Alexander S. , Sal’nikova Elena I. , Azarapin Nikita O. , Shelpakova Natalia A. , Müller-Buschbaum Klaus , Denisenko Yuriy G.
Published: November 2023

A new polymorphic modification of lanthanum sulfate was obtained by thermal dehydration of the respective nonahydrate. According to powder X-ray diffraction, it was established that β-La2(SO4)3 crystallized in the C2/c space group of the monoclinic system with the KTh2(PO4)3 structure type (a = 17.6923(9), b = 6.9102(4), c = 8.3990(5) Å, β = 100.321(3)°, and V = 1010.22(9) Å3). Temperature dependency studies of the unit cell parameters indicated almost zero expansion along the a direction in the temperature range of 300–450 K. Presumably, this occurred due to stretching of the [LaO9]n chains along the c direction, which occurred without a significant alteration in the layer thickness over the a direction. A systematic study of the formation and destruction processes of the lanthanum sulfates under heating was carried out. In particular, the decisive impact of the chemical composition and formation energy of compounds on the thermodynamic and kinetic parameters of the processes was established. DFT calculations showed β-La2(SO4)3 to be a dielectric material with a bandgap of more than 6.4 eV. The processing of β-La2(SO4)3 with the Kubelka–Munk function exhibited low values below 6.4 eV, which indicated a fundamental absorption edge above this energy that was consistent with LDA calculations. The Raman and infrared measurements of β-La2(SO4)3 were in accordance with the calculated spectra, indicating that the obtained crystal parameters represented a reliable structure.
Trade-Offs among Immune Mechanisms: Bacterial-Challenged Spodoptera frugiperda Larvae Reduce Nodulation Reactions during Behavioral Fever
Authors: Zhang Lei , Goodman Cynthia L. , Ringbauer Joseph A. , Jiang Xingfu , Lv Weixiang , Xie Dianjie , Reall Tamra , Stanley David
Published: November 2023

Insect innate immunity is composed of cellular and humoral reactions, the former acting via circulating hemocytes and the latter via immune signaling that lead to the production of antimicrobial peptides and phenol oxidase-driven melanization. Cellular immunity involves direct interactions between circulating hemocytes and invaders; it includes internalization and killing microbes (phagocytosis) and formation of bacterial-laden microaggregates which coalesce into nodules that are melanized and attached to body walls or organs. Nodulation can entail investing millions of hemocytes which must be replaced. We hypothesized that biologically costly hemocyte-based immunity is traded off for behavioral fevers in infected larvae of fall armyworms, Spodoptera frugiperda, that were allowed to fever. We tested our hypothesis by infecting larvae with the Gram-negative bacterium, Serratia marcescens, placing them in thermal gradients (TGs) and recording their selected body temperatures. While control larvae selected about 30 °C, the experimental larvae selected up 41 °C. We found that 4 h fevers, but not 2, 6 or 24 h fevers, led to increased larval survival. Co-injections of S. marcescens with the prostaglandin (PG) biosynthesis inhibitor indomethacin (INDO) blocked the fevers, which was reversed after co-injections of SM+INDO+Arachidonic acid, a precursor to PG biosynthesis, confirming that PGs mediate fever reactions. These and other experimental outcomes support our hypothesis that costly hemocyte-based immunity is traded off for behavioral fevers in infected larvae under appropriate conditions.
Association between Serum Testosterone and Aortic Valve Stenosis: A Prospective Cohort Study
Authors: Laukkanen Jari A. , Lavie Carl J. , Kunutsor Setor K.
Published: November 2023

Serum testosterone is associated with atherosclerotic cardiovascular disease, which shares risk factors with aortic stenosis (AS). The association between serum testosterone and AS has not been previously investigated. We aimed to assess the prospective association between serum testosterone and risk of AS. Serum testosterone was determined at baseline using a radioimmunoassay kit in 2577 men aged 42–61 years recruited into the Kuopio Ischemic Heart Disease prospective cohort study. Hazard ratios (HRs) with 95% confidence intervals (Cis) were estimated for AS. After a median follow-up of 27.2 years, 119 cases of AS were recorded. The risk of AS increased continuously with increasing serum testosterone across the range 25–39 nmol/L (p-value for nonlinearity = 0.49). In an analysis adjusted for age, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, smoking status, history of type 2 diabetes, history of coronary heart disease, and alcohol consumption, the HR (95% CI) for AS was 1.39 (1.10–1.76) per 10 nmol/L increase in serum testosterone. When alcohol consumption was replaced with physical activity, the HR (95% CI) was 1.38 (1.09–1.74). Comparing the bottom versus top third of serum testosterone, the corresponding (adjusted) risk estimates were 1.76 (1.11–2.81) and 1.76 (1.10–2.80), respectively. In middle-aged and older Finnish men, elevated levels of serum testosterone were associated with an increased risk of AS. Further research is needed to replicate these findings and assess any potential relevance of serum testosterone in AS prevention.
What Is the Role of Traction Test Radiographs in the Preoperative Planning of Adolescent Idiopathic Scoliosis?
Authors: La Maida Giovanni Andrea , Gallazzi Enrico , Ramella Federica , Ferraro Marcello , Della Valle Andrea , Cecconi Davide , Misaggi Bernardo
Published: November 2023

Lower instrumented vertebra (LIV) selection is critical to avoid complications like adding-on. This study aims to determine the usefulness of the traction test (TR) in selecting the LIV during surgery for adolescent idiopathic scoliosis (AIS). We analyzed 42 AIS patients with Lenke 1 curves who had preoperative, postoperative, and at least 12-month follow-up X-rays, as well as preoperative side bending (SB) and TR radiograms. Neutral vertebra (NV), stable vertebra (SV), lower instrumented vertebra (LIV), and Cobb angles were identified and compared on all radiographic images. In 23 cases, the TR resulted in SV proximalization compared to the preoperative X-rays, while in 8 cases, SV-TR was more distal. This distalization occurred in 50% of Lenke 1C curves, where a greater correction of the distal curve was found. NV-TR was proximal to NV-preop in 9 cases, while NV-SB was proximal in 22 cases. LIV was proximal to SV-TR in 8 cases, while it was proximal to SV-preop in 22. One patient with LIV proximal to SV-TR developed adding-on. In conclusion, the TR is crucial in AIS preoperative planning as it provides information distinct from that of standard X-rays and SB: (1) it better assesses gravitational stability than rotational stability; and (2) choosing LIV equal to or proximal to SV-TR may prevent adding-on, except in ‘flexible’ Lenke 1C curves where LIV should be equal or distal to SV-preop.
New-Onset Atrial Fibrillation in the Critically Ill COVID-19 Patients Hospitalized in the Intensive Care Unit
Authors: Zakynthinos George E. , Tsolaki Vasiliki , Oikonomou Evangelos , Vavouranakis Manolis , Siasos Gerasimos , Zakynthinos Epaminondas
Published: November 2023

New-onset atrial fibrillation (NOAF) is the most frequently encountered cardiac arrhythmia observed in patients with COVID-19 infection, particularly in Intensive Care Unit (ICU) patients. The purpose of the present review is to delve into the occurrence of NOAF in COVID-19 and thoroughly review recent, pertinent data. However, the causality behind this connection has yet to be thoroughly explored. The proposed mechanisms that could contribute to the development of AF in these patients include myocardial damage resulting from direct virus-induced cardiac injury, potentially leading to perimyocarditis; a cytokine crisis and heightened inflammatory response; hypoxemia due to acute respiratory distress; disturbances in acid-base and electrolyte levels; as well as the frequent use of adrenergic drugs in critically ill patients. Additionally, secondary bacterial sepsis and septic shock have been suggested as primary causes of NOAF in ICU patients. This notion gains strength from the observation of a similar prevalence of NOAF in septic non-COVID ICU patients with ARDS. It is plausible that both myocardial involvement from SARS-CoV-2 and secondary sepsis play pivotal roles in the onset of arrhythmia in ICU patients. Nonetheless, there exists a significant variation in the prevalence of NOAF among studies focused on severe COVID-19 cases with ARDS. This discrepancy could be attributed to the inclusion of mixed populations with varying degrees of illness severity, encompassing not only patients in general wards but also those admitted to the ICU, whether intubated or not. Furthermore, the occurrence of NOAF is linked to increased morbidity and mortality. However, it remains to be determined whether NOAF independently influences outcomes in critically ill COVID-19 ICU patients or if it merely reflects the disease’s severity. Lastly, the management of NOAF in these patients has not been extensively studied. Nevertheless, the current guidelines for NOAF in non-COVID ICU patients appear to be effective, while accounting for the specific drugs used in COVID-19 treatment that may prolong the QT interval (although drugs like lopinavir/ritonavir, hydrochlorothiazide, and azithromycin have been discontinued) or induce bradycardia (e.g., remdesivir).
Reasons for Discontinuing Treatment with Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Diabetes in Real-World Settings: The KAMOGAWA-A Study
Authors: Saijo Yuto , Okada Hiroshi , Hata Shinnosuke , Nakajima Hanako , Kitagawa Nobuko , Okamura Takuro , Osaka Takafumi , Kitagawa Noriyuki , Majima Saori , Senmaru Takafumi , Ushigome Emi , Nakanishi Naoko , Hamaguchi Masahide , Fukui Michiaki
Published: November 2023

Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a class of antidiabetic agents known to exert cardioprotective, renoprotective, and hypoglycemic effects. However, these agents have been associated with adverse effects, such as genital infection, volume depletion, hypoglycemia, and diabetic ketoacidosis, resulting in drug discontinuation. Herein, we aimed to determine the reasons for discontinuing treatment with SGLT2is among Japanese patients with diabetes. This retrospective cohort study enrolled 766 patients with diabetes who had initiated SGLT2is between January 2014 and September 2021. The follow-up period was 2 years from the initiation of the SGLT2is. Overall, 97 patients (12.7%) discontinued the SGLT2is during the follow-up period. The most common reasons for discontinuing the SGLT2is were frequent urination (19.6%), followed by genital infection (11.3%), improved glycemic control (10.6%), and renal dysfunction (8.2%). A comparison of the characteristics between the continuation and the discontinuation group was conducted, excluding those who discontinued the SGLT2is because of improved glycemic control. The patients in the discontinuation group (68 [55–75] years) were older than those in the continuation group (64 [53–71] years; p = 0.003). Importantly, we found no significant association between diabetes duration, diabetic control, renal function, or complications of diabetes in both groups. This real-world study revealed that frequent urination was the most common reason underlying SGLT2i discontinuation among Japanese patients with diabetes. To avoid discontinuation, precautions against various factors that may cause frequent urination must be implemented.
Risk Factors for Severe Pain and Impairment of Daily Life Activities after Cesarean Section—A Prospective Multi-Center Study of 11,932 Patients
Authors: Emrich Norah L. A. , Tascón Padrón Laura , Komann Marcus , Arnold Christin , Dreiling Johannes , Meißner Winfried , Strizek Brigitte , Gembruch Ulrich , Jiménez Cruz Jorge
Published: November 2023

Cesarean section (CS) is the most widely performed and one of the most painful surgeries. This study investigated postoperative pain after CS using patient-related outcomes (PROs) to identify risk factors for severe pain. The secondary outcome was to evaluate the influence of surgery indication (primary CS (PCS) vs. urgent CS (UCS)). This multi-center, prospective cohort study included data submitted to the pain registry “quality improvement in postoperative pain treatment” (QUIPS) between 2010 and 2020. In total, 11,932 patients were evaluated. Median of maximal pain was 7.0 (numeric rating scale (NRS) 0 to 10); 53.9% suffered from severe pain (NRS ≥ 7), this being related to impairment of mood, ambulation, deep breathing and sleep, as well as more vertigo, nausea and tiredness (p < 0.001). Distraction, relaxation, mobilization, having conversations, patient-controlled analgesia (PCA) and pain monitoring were shown to be protective for severe pain (p < 0.001). Maximal pain in PCS and UCS was similar, but UCS obtained more analgesics (p < 0.001), and experienced more impairment of ambulation (p < 0.001) and deep breathing (p < 0.05). Severe pain has a major effect on daily-life activities and recovery after CS, and depends on modifiable factors. More effort is needed to improve the quality of care after CS.
Feasibility and Safety Study of Concomitant Left Bundle Branch Area Pacing and Atrioventricular Node Ablation with Same-Day Hospital Dismissal
Authors: Liu Zhigang , Liu Xiaoke
Published: November 2023

Background: Left bundle branch area pacing (LBBAP) has rapidly emerged as a promising modality of physiologic pacing and has demonstrated excellent lead stability. In this retrospective study, we evaluate whether this pacing modality can allow concomitant atrioventricular node (AVN) ablation and same-day dismissal. Methods: Twenty-four consecutive patients (female 63%, male 37%) with an average age of 78 ± 5 years were admitted for pacemaker (75%)/defibrillator (25%) implantations and concomitant AVN ablation. Device implantation with LBBAP was performed first, followed by concomitant AVN ablation through left axillary vein access to allow for quicker post-procedure ambulation. The patients were discharged on the same day after satisfactory post-ambulation device checks. Results: LBBAP was successful in 22 patients (92% in total, 20 patients had an LBBP and two patients had a likely LBBP), followed by AVN ablation from left axillary vein access (21/24, 88%). All patients had successful post-op chest x-rays, post-ambulation device checks, and were discharged on the same day. After a mean follow up of three months, no major complications occurred, such as LBBA lead dislodgement requiring a lead revision. The LBBA lead pacing parameters immediately after implantation vs. three-month follow up were a capture threshold of 0.8 ± 0.3 V@0.4 ms vs. 0.6 ± 0.3 V@0.4 ms, sensing 9.9 ± 3.9 mV vs. 10.4 ± 4.1 mV, and impedance of 710 ± 216 ohm vs. 544 ± 110 ohm. The QRS duration before and after AVN ablation was 117 ± 32 ms vs. 123 ± 14 ms. Mean LVEF before and three months after the implantation was 44 ± 14% vs. 46 ± 12%. Conclusion: LBBA pacing not only offers physiologic pacing, but also allows for a concomitant AVN ablation approach from the left axillary vein and safe same-day hospital dismissal.
Pleural Mesothelioma: Advances in Blood and Pleural Biomarkers
Authors: Sorino Claudio , Mondoni Michele , Marchetti Giampietro , Agati Sergio , Inchingolo Riccardo , Mei Federico , Flamini Sara , Lococo Filippo , Feller-Kopman David
Published: November 2023

Pleural mesothelioma (PM) is a type of cancer that is highly related to exposure to asbestos fibers. It shows aggressive behavior, and the current therapeutic approaches are usually insufficient to change the poor prognosis. Moreover, apart from staging and histological classification, there are no validated predictors of its response to treatment or its long-term outcomes. Numerous studies have investigated minimally invasive biomarkers in pleural fluid or blood to aid in earlier diagnosis and prognostic assessment of PM. The most studied marker in pleural effusion is mesothelin, which exhibits good specificity but low sensitivity, especially for non-epithelioid PM. Other biomarkers found in pleural fluid include fibulin-3, hyaluronan, microRNAs, and CYFRA-21.1, which have lower diagnostic capabilities but provide prognostic information and have potential roles as therapeutic targets. Serum is the most investigated matrix for biomarkers of PM. Several serum biomarkers in PM have been studied, with mesothelin, osteopontin, and fibulin-3 being the most often tested. A soluble mesothelin-related peptide (SMRP) is the only FDA-approved biomarker in patients with suspected mesothelioma. With different serum and pleural fluid cut-offs, it provides useful information on the diagnosis, prognosis, follow-up, and response to therapy in epithelioid PM. Panels combining different markers and proteomics technologies show promise in terms of improving clinical performance in the diagnosis and monitoring of mesothelioma patients. However, there is still no evidence that early detection can improve the treatment outcomes of PM patients.
The Benefits and Imperative of Venous Thromboembolism Risk Screening for Hospitalized Patients: A Systematic Review
Authors: Bakhsh Ebtisam
Published: November 2023

Venous thromboembolism (VTE) is a major preventable condition in hospitalized patients globally. This systematic review evaluates the effectiveness and clinical significance of venous thromboembolism (VTE) risk-screening protocols in preventing VTE events among hospitalized patients. Databases, including PubMed, Embase and Cochrane, were searched without date limits for studies comparing outcomes between hospitalized patients who did and did not receive VTE risk screening using standard tools. Twelve studies, enrolling over 139,420 patients, were included. Study quality was assessed using the ROBVIS tool. The results were summarized narratively. The findings show significant benefits of using VTE risk screening versus usual care across various outcomes. Using recommended tools, like Caprini, Padua and IMPROVE, allowed for the accurate identification of high-risk patients who benefited most from prevention. Formal screening was linked to much lower VTE rates, shorter hospital stays, fewer deaths and better use of preventive strategies matched to estimated clot risk. This review calls for the widespread adoption of VTE risk screening as an important safety step for at-risk hospital patients. More high-quality comparative research is needed to validate screening tools in different settings and populations. In summary, VTE risk screening is essential for healthcare systems to reduce life-threatening VTE events and improve patient outcomes through properly targeted preventive methods.
Cardiorespiratory Fitness and Risk of Cardiovascular Events and Mortality in Middle Age Patients without Known Cardiovascular Disease
Authors: Aker Amir , Saliba Walid , Bahouth Fadel , Naoum Ibrahim , Zafrir Barak
Published: November 2023

Background: Low cardiorespiratory fitness is an established risk predictor for chronic non-communicable diseases. We aimed to investigate the prognostic significance of fitness level on the risk of major adverse cardiac events (MACE, the composite of myocardial infarction, stroke, or all-cause death), in a contemporary cohort of middle-aged subjects without cardiovascular disease. Methods: Retrospective analysis of patients aged 40–60 years without a history of cardiovascular disease. Degree of fitness was determined according to a graded, maximal treadmill exercise stress testing (EST) time achieved, classified into age- and sex-specific quintiles (Q), and categorized as low (Q1), moderate (Q2–Q4) or high (Q5) fitness groups. A multivariable Cox proportional hazard regression model was used to assess the association of fitness level with the risk of MACE. Results: A total of 6836 patients were included, of which 44.5% were women, and the mean age was 52 years. Overall, 289 MACE events occurred during a median follow-up of 7 years. Level of fitness was inversely associated with the presence of cardiovascular risk factors. The multivariable adjusted hazard ratio (95% confidence interval) for MACE was 1.65 (1.12–2.44) and 2.17 (1.40–3.38) in those at moderate and low fitness levels, compared to the high-fitness group (reference), respectively. For each decrease of one metabolic equivalent (MET) unit achieved at peak exercise, the relative risk for MACE increased by 18%. The association between low fitness and MACE was not modified by other risk factors (P-for-interaction non-significant). Conclusions: Low fitness level, as captured by a maximal treadmill EST, is an independent risk predictor for MACE among middle-age individuals without known cardiovascular disease. The association of low fitness with high burden of cardiometabolic risk factors highlight the importance of lifestyle intervention in this patient population.
Digital Evaluation of Vertical Ridge Augmentation with the Modified Shell Technique Using a Xenogeneic Bone Lamina: A Case Series
Authors: Happe Arndt , Blender Sarah M. , Luthardt Ralph G. , Rudolph Heike , Kuhn Katharina
Published: November 2023

Vertical ridge augmentation is a demanding and technique-sensitive surgical procedure. In the present case series, cone beam CT (CBCT) scans from the clinical routine of patients treated using a novel approach for vertical bone augmentation were assessed. All patients showed a single-tooth class 5 defect and were treated using a modification of the original shell technique. Cortical bone plates were replaced with a lamina composed of a partially demineralized porcine xenograft. CBCT scans of six consecutive patients were treated with the lamina and particulate bone from the mandibular ramus prior to a single tooth implant in the anterior maxilla were included. Pre- and postsurgical CBCT data sets were superimposed and analyzed digitally using surface matching and Boolean subtraction. The volume of the grafted area was calculated with and without the xenograft. The vertical gain of the ridge height measured in this case series varied from 7 to 11.3 mm. The mean vertical gain was 8.97 mm. The mean volume including the xenograft was 382.59 mm3 (SD 73.39) and 250.84 mm3 (SD 53.67) without the lamina. The modified shell technique used in this case series for the vertical augmentation of single-tooth class 5 defects provided sufficient bone for single implant restorations.
Risk Factor Analysis for Long-Term Graft Survival Following Pediatric Kidney Transplantation: The Importance of Pretransplantation Time on Dialysis and Donor/Recipient Age Difference
Authors: Marcou Marios , Galiano Matthias , Tzschoppe Anja , Sauerstein Katja , Wach Sven , Taubert Helge , Wullich Bernd , Hirsch-Koch Karin , Apel Hendrik
Published: November 2023

Recognizing risk factors that may negatively affect long-term graft survival following pediatric kidney transplantation is a key element in the decision-making process during organ allocation. We retrospectively reassessed all cases of pediatric kidney transplantation performed in our center in the last 20 years with the aim of determining baseline characteristics that could be identified as prognostic risk factors for long-term graft survival. Between 2001 and 2020, a total of 91 kidney transplantations in children under the age of 18 years were undertaken in our center. Early graft failure was observed in six of the 91 patients (7%). The median follow-up of the remaining 85 children was 100 months, and the overall kidney graft survival rates at 5, 10, 15 and 20 years were 85.2%, 71.4%, 46.0% and 30.6%, respectively. Small children with a body surface area of <1 m2 were significantly associated with better long-term graft survival outcomes, while adolescents aged more than twelve years showed poorer graft survival rates than younger children. Body surface area of the recipient of ≥1 m2, pretransplantation duration of the recipient on dialysis ≥18 months, hemodialysis prior to transplantation and donor/recipient age difference of ≥25 years were significantly associated with poorer long-term graft survival.
Six-Month Soft Tissues Healing after Lower Third Molar Extraction: Comparison of Two Different Access Flaps
Authors: Pardo Alessia , Signoriello Annarita , Corrà Martina , Favero Vittorio , De’Manzoni Casarola Rachele , Albanese Massimo
Published: November 2023

Background: As specific flap designs performed for lower third molar extractions usually influence periodontal healing of the adjacent first and second molars, this study aimed to evaluate the periodontal conditions of these sites after 6 months post-surgery. Methods: Forty patients, aged 14–30 years, were included. Surgical extraction of the lower third molar was performed through a flap with papilla detachment (a modified envelope technique with detachment of gingival papilla between the first and second molars) or a trapezoidal flap (characterized by mesial- and distal-releasing incisions). Periodontal parameters at the first and second molar sites were assessed for visible plaque index, bleeding on probing, recession, probing pocket depth, and clinical attachment loss before surgery (T0), one month (T1), and six months after extraction (T2). Results: No statistical differences were found for the plaque and bleeding indexes between the two flaps at each observation time and considering both time intervals. For recession, no statistical differences were found between the two flaps considering the final time interval. For probing pocket depth at the second molar site, both techniques registered a significant increase between T0 and T1, followed by a decrease up to T2. For clinical attachment loss, mean values assessed for the first and second molar sites demonstrated evidently increased values between T0 and T1, followed by moderate decreases up to T2. Conclusions: Considering short (T1) and mid-term (T2) follow-ups, a specific flap design does not seem to particularly influence periodontal healing six months after surgery.
A Review of Delamination Damage of Composite Materials
Authors: Huang Tao , Bobyr Mykola
Published: November 2023

The theoretical and practical achievements in the field of the theory of strength and reliability of composite materials are discussed in a review conducted on the scientific research conducted on the effect of delamination on the reliability and quality of composites. The methodological aspects of the stability of the mechanical characteristics of composite materials under the combined action of cyclic and impact loads are examined, as are the manufacturing and processing technologies. The reasons for delamination, such as technological, manufacturing and application, free edge, joints and loads, are revealed. The influence of delamination on the bearing capacity of structural elements made of composite materials is analyzed. The mechanism of delamination growth is outlined, and the criteria and processes are defined, such as the growth of delamination cracks in a multidirectional laminated plate from a straight edge, edge delamination during plate bending, delamination in plates in the field of residual stresses, etc. The importance of taking into account the visco-plastic effect at the top of the edge crack of delamination of composite materials is emphasized. The concept of critical delamination behavior is characterized, and the issues of delamination stability are described.
Synthesis of BaSnO3 as a Highly Dispersed Additive for the Preparation of Proton-Conducting Composites
Authors: Loginov Anton V. , Aparnev Alexander I. , Uvarov Nikolai F. , Ponomareva Valentina G. , Bannov Alexander G.
Published: November 2023

The process of thermolysis of barium hydroxostannate BaSn(OH)6 as a precursor for preparing barium stannate BaSnO3 has been investigated using the method of differential thermal analysis. Thermal decomposition products of the precursor were characterized using X-ray diffraction, IR spectroscopy, low-temperature nitrogen adsorption, and scanning electron microscopy. It was shown that dehydration at nearly 270 °C resulted in the formation of an X-ray amorphous multiphase product, from which single-phase barium stannate crystallized at temperatures above 600 °C. The synthesized barium stannate was used as a functional additive to prepare composite proton electrolytes in the CsHSO4-BaSnO3 system. The structural and transport properties of the obtained system were investigated. It is shown that the highly conductive state of the salt is stabilized in a wide range of temperatures. High conductivity values of composite solid electrolytes in the medium temperature range create the possibility of their use as solid electrolyte membrane materials.
Does the Degree of Prematurity Relate to the Bayley-4 Scores Earned by Matched Samples of Infants and Toddlers across the Cognitive, Language, and Motor Domains?
Authors: Winter Emily L. , Caemmerer Jacqueline M. , Trudel Sierra M. , deLeyer-Tiarks Johanna , Bray Melissa A. , Dale Brittany A. , Kaufman Alan S.
Published: November 2023

The literature on children born prematurely has consistently shown that full-term babies outperform preterm babies by about 12 IQ points, even when tested as adolescents, and this advantage for full-term infants extends to the language and motor domains as well. The results of comprehensive meta-analyses suggest that the degree of prematurity greatly influences later test performance, but these inferences are based on data from an array of separate studies with no control of potential confounding variables such as age. This study analyzed Bayley-4 data for 66 extremely premature infants and toddlers (<32 weeks), 70 moderately premature children (32–36 weeks), and 133 full-term children. All groups were carefully matched on key background variables by the test publisher during the standardization of the Bayley-4. This investigation analyzed data on the five subtests: cognitive, expressive communication, receptive communication, fine motor, and gross motor. A multivariate analysis of covariance (MANCOVA) assessed for group mean differences across the three subsamples, while controlling for the children’s age. Extremely premature children scored significantly lower than moderately premature children on all subtests, and both preterm groups were significantly outscored by the full-term sample across all domains. In each set of comparisons, the cognitive and motor subtests yielded the largest differences, whereas language development, both expressive and receptive, appeared the least impacted by prematurity. A follow-up MANOVA was conducted to examine full-term versus preterm discrepancies on the five subtests for infants (2–17 months) vs. toddlers (18–42 months). For that analysis, the two preterm groups were combined into a single preterm sample, and a significant interaction between the age level and group (full-term vs. preterm) was found. Premature infants scored lower than premature toddlers on receptive communication, fine motor, and cognitive. Neither expressive communication nor gross motor produced significant discrepancies between age groups The findings of this study enrich the preterm literature on the degree of prematurity; the age-based interactions have implications for which abilities are most likely to improve as infants grow into toddlerhood.
Design Optimization of a Mooring System for an Offshore Aquaculture Platform
Authors: Wang Liang , Wang Lei , Cui Mingchao , Liang Mingxiao , Liu Haitian
Published: November 2023

In the present paper, the mooring system of an offshore aquaculture platform is designed and optimized, applying a shallow water mooring system design methodology which combines the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) and the cable–platform coupled model. One mooring design is first given using the proposed methodology. Two reference mooring systems are modified based on an NSGA-II design, and AIP criteria and expertise. The hydrodynamic performance of the offshore aquaculture platform with these three mooring systems is compared via use of a potential flow time–domain numerical simulation. A physical model-scale experiment is carried out to validate the numerical coupled model. Both numerical and experimental results confirm the effectiveness of present model. The comparative analysis shows that the mooring system designed using NSGA-II can provide a relative radical solution compared to the other two mooring designs when considering a limited budget.
Deformation Anomalies Accompanying Tsunami Origins near the Japanese Islands
Authors: Dolgikh Grigory , Dolgikh Stanislav
Published: November 2023

In the paper, we analyze laser strainmeter data for the period from 2014 to 2022 to identify deformation anomalies that led to the generation of tsunamis in the area of the Japanese Islands. It is impossible to determine the main characteristics of a tsunami from the deformation anomaly registered by the laser strainmeter, but it is possible to calculate the seabed displacement in the epicenter of a tsunami formation, which causes the tsunami. We have established that the relationship between the registered deformation anomalies and the seabed displacement in the tsunami source in the area of the Japanese Islands is similar to the same relationships found in other regions of the Earth (Indonesia, Latin America, and the West Coast of North America). This result allows us to assert that such a relationship should be typical of any region of the Earth. The obtained results are aimed at solving the problem of reliable short-term tsunami forecasting, which allows for the avoidance of false alarms that lead to significant socio-economic damage.
Gender-Related Factors Influence the Subjective Perception of Deformity in Patients Undergoing Surgery for Idiopathic Scoliosis
Authors: Bizzoca Davide , Solarino Giuseppe , Moretti Anna Maria , Moretti Lorenzo , Dramisino Pasquale , Piazzolla Andrea , Moretti Biagio
Published: November 2023

The present study aims to depict the importance of gender-related factors in the subjective perception of spine deformity in adolescents undergoing posterior instrumented fusion for scoliosis. Patients undergoing posterior spinal instrumentation and fusion (PSF) for idiopathic adolescent scoliosis (AIS) were recruited. The following data were recorded: gender, age, parents’ civil status, Tegner Activity Scale (TAS), body mass index (BMI), concomitant diseases, and history of neuropsychological disorders. Each patient underwent clinical and radiological evaluations according to the protocol used at our institution. All the patients were assessed before surgery using the following Patient-Reported Outcome Measures (PROMs): the Italian version of the revised Scoliosis Research Society—22 patient questionnaire (SRS-22R), the Quality-of-Life Profile for Spinal Deformities (QLPSDs) questionnaire, and the Spinal Appearance Questionnaire (SAQ). The present study recruited 80 patients (male: 19, female: 61). A significant correlation was observed between BMI, TAS, and subjective perception scores. A worse deformity perception was observed in female patients and patients with divorced parents. Gender-related factors impact the subjective perception of spine deformity in patients undergoing PSF for AIS. Specific assessment and correction are needed to improve postoperative outcomes in these patients.
miRNA-Based Technologies in Cancer Therapy
Authors: Pagoni Maria , Cava Claudia , Sideris Diamantis C. , Avgeris Margaritis , Zoumpourlis Vassilios , Michalopoulos Ioannis , Drakoulis Nikolaos
Published: November 2023

The discovery of therapeutic miRNAs is one of the most exciting challenges for pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of miRNA biology has grown considerably. Many studies have demonstrated that miRNA expression is dysregulated in many diseases, making them appealing tools for novel therapeutic approaches. This review aims to discuss miRNA biogenesis and function, as well as highlight strategies for delivering miRNA agents, presenting viral, non-viral, and exosomic delivery as therapeutic approaches for different cancer types. We also consider the therapeutic role of microRNA-mediated drug repurposing in cancer therapy.
Analysis of Prevalence and Clinical Features of Aortic Stenosis in Patients with and without Bicuspid Aortic Valve Using Machine Learning Methods
Authors: Irtyuga Olga , Babakekhyan Mary , Kostareva Anna , Uspensky Vladimir , Gordeev Michail , Faggian Giuseppe , Malashicheva Anna , Metsker Oleg , Shlyakhto Evgeny , Kopanitsa Georgy
Published: November 2023

Aortic stenosis (AS) is the most commonly diagnosed valvular heart disease, and its prevalence increases with the aging of the general population. However, AS is often diagnosed at a severe stage, necessitating surgical treatment, due to its long asymptomatic period. The objective of this study was to analyze the frequency of AS in a population of cardiovascular patients using echocardiography (ECHO) and to identify clinical factors and features associated with these patient groups. We utilized machine learning methods to analyze 84,851 echocardiograms performed between 2010 and 2018 at the National Medical Research Center named after V.A. Almazov. The primary indications for ECHO were coronary artery disease (CAD) and hypertension (HP), accounting for 33.5% and 14.2% of the cases, respectively. The frequency of AS was found to be 13.26% among the patients (n = 11,252). Within our study, 1544 patients had a bicuspid aortic valve (BAV), while 83,316 patients had a tricuspid aortic valve (TAV). BAV patients were observed to be younger compared to TAV patients. AS was more prevalent in the BAV group (59%) compared to the TAV group (12%), with a p-value of <0.0001. By employing a machine learning algorithm, we randomly identified significant features present in AS patients, including age, hypertension (HP), aortic regurgitation (AR), ascending aortic dilatation (AscAD), and BAV. These findings could serve as additional indications for earlier observation and more frequent ECHO in specific patient groups for the earlier detection of developing AS.
Soybean (Glycine max) Cropland Suitability Analysis in Subtropical Desert Climate through GIS-Based Multicriteria Analysis and Sentinel-2 Multispectral Imaging
Authors: Ahmad Noman , Younas Fazila , Ahmad Hamaad Raza , Sarfraz Muhammad , Ayub Muhammad Ashar , Maqsood Muhammad Aamer , Rasul Fahd , Sardar Muhammad Fahad , Mehmood Tariq , Ajarem Jamaan S. , Maoda Saleh n. , Li Xiang , Cui Zhaojie
Published: November 2023

Soybean (Glycine max) is a protein-rich oilseed crop that is extensively used for cooking oil and poultry feed and faces significant challenges due to adverse global climatic conditions aggravated by the ongoing climate crisis. In response to this critical issue, this study was initiated to assess suitable zones for soybean cultivation, aiming to facilitate informed land use decisions within the semi-arid terrestrial ecosystem. Through the utilization of geostatistical interpolation, data layers encompassing soil, irrigation water, land use and land cover, topographic features, and climate information were generated and overlaid based on criterion weightage derived from the Analytic Hierarchy Process. The accuracy of land use and land cover was rigorously evaluated, yielding a 70% overall accuracy and a Kappa (K) value of 0.61, signifying an acceptable level of precision. Validation through the Receiver Operating Characteristic curve for soybean crop suitability demonstrated a highly satisfactory area under the curve of 0.738. The study estimates that out of 172,618.66 hectares, approximately 47.46% of the land is highly suitable (S1) for soybean production, followed by 21.36% moderately suitable (S2), 11.91% marginally suitable (S3), 7.00% currently not suitable (N1), and 12.28% permanently not suitable (N2). Conclusively, the findings suggest that the study area exhibits conducive climatic conditions, optimal soil health, and access to quality irrigation water, all of which have the potential to support soybean crops with improved agronomic practices. This investigation offers valuable insights to both farmers and policymakers concerning irrigation water quality, agricultural productivity, and soil degradation.
Multi-Scenario Prediction Analysis of Carbon Peak Based on STIRPAT Model-Take South-to-North Water Diversion Central Route Provinces and Cities as an Example
Authors: Meng Qingxiang , Li Baolu , Zheng Yanna , Zhu Huimin , Xiong Ziyi , Li Yingchao , Li Qingsong
Published: November 2023

With the increase in energy demand, environmental issues such as carbon emissions are becoming more and more prominent. China will scale its intended nationally determined contributions by adopting more vigorous policies and measures. China aims to have CO2 emissions peak before 2030 and achieve carbon neutrality before 2060. The current challenge and priority of China’s high-quality development is to ensure a harmonious balance between the ecological environment and the economy. The South-to-North Water Diversion Project passes through Beijing, Tianjin, Henan, and Hebei, which were chosen as the study sites. The carbon emission data was from the China Carbon Emission Database 2000–2019. Decoupling modeling using statistical yearbook data from four provinces and municipalities. KMO and Bartlett’s test used SPSS 27 software. The selection of indicators was based on relevance. Analyses were performed using the extended STIRPAT model and ridge regression. Moreover, projections of carbon peaks in the study area for 2020–2035 under different rates of change were simulated by the scenario analysis method. The results show that: (1) The decoupling analysis of the four provinces and cities from 2000-2019 gradually shifts to strong decoupling; (2) Resident population, energy structure, and secondary industry as a proportion of GDP significantly impact carbon emissions; (3) From 2000–2035, Beijing and Henan experienced carbon peaks. The peak time in Beijing was 96.836 million tons in 2010. The peak time in Henan was 654.1004 million tons in 2011; (4) There was no peak in Hebei from 2000–2035.