bluuebunny/crossref_metadata_2025 huggingface dataset:
PROSPECTS FOR USING COMPONENT MESENCHYMAL STEM CELLS AS A WAY TO IMPROVE THE QUALITY OF BULLS’ SPERM
Authors: Korochkina E. A. , Trifonova A. V. , Nikitin V. V. , Glavatskay D. E. , Pushkina V. S.
Published: January 2025

The aim of this study was to investigate the effect of mesenchymal stem cell derivative (lysate) from adipose tissue (AT) and bone marrow (BM) of bulls on the quality of native sperm. A total of 10 samples were taken. Each sample was divided into aliquots (after centrifugation (7 min 600 rpm) and removal of seminal plasma) according to the following groups: control (sperm 7x1010 cells/ml + PBS buffer 100 μl), the first experimental (sperm 7x1010 cells/ml + BM MSC lysate 2x108 cells/ml), the second experimental (sperm 7x1010 cells/ml + AT MSC lysate 2x108 cells/ml).A four-stage assessment of sperm quality was carried out: 0, 2 and 4 hours of incubation at a temperature of 37℃.According to the results of the studies, a reliable decrease in the number of normal spermatozoa was recorded when assessing 4-hour sperm incubation.At the same time, the difference in values in the control and first experimental groups was 1.3 times (p < 0.05 for both groups), in the second experimental - 1.4 times (p < 0.05) compared with the data of 0 hours of incubation.The highest number of morphologically normal spermatozoa was recorded in the first experimental group, when incubating spermatozoa with bone marrow MSC secretion products.A statistically significant decrease in the number of progressively moving spermatozoa was obtained after 2 and 4 hours of incubation compared with the data obtained when assessing motility at 0 hours of incubation.Thus, the difference in values in the control group was 1.4 (2 and 4 hours, p<0.01), in the first experimental group - 1.1 (p<0.05) and 1.4 (p<0.01), in the second experimental group - 1.2 (p<0.05) and 1.6 (p<0.05) times 2 and 4 hours, respectively.The highest number of progressively moving spermatozoa was recorded during the interaction of bovine germ cells with the MSC lysate during two hours of incubation, obtained from the bone marrow and amounted to 74.75±2.39%.
EFFICIENCY OF MSC USING AFTER GOAT SPERM CRYOPRESERVATION
Authors: Korochkina E. A. , Trifonova A. V. , Finageev E. Y. , Glavatskay D. E. , Pushkina V. S.
Published: January 2025

The aim of the study was to establish the efficiency of using mesenchymal stem cells from adipose tissue and bone marrow of goats after sperm cryopreservation. The results of four-hour incubation of sperm samples after thawing indicate a reliable difference in the values during incubation with mesenchymal stem cells (MSCs) from adipose tissue/bone marrow and without them (OptiXcell medium). Thus, during four -hour incubation of sperm after thawing, a statistically significant decrease in the number of normal spermatozoa was noted in all study groups. At the same time, the difference in values in the control group was 1.3 (p<0.01, 2 hours) and 1.4 (p<0.01, 4 hours) times; the first experimental group - 1.1 (p<0.01, 4 hours) times; the second experimental group – 1.1 (p < 0.01, 2 hours) and 1.3 (p < 0.01, 4 hours) times compared to the results of 0 hours of incubation. Samples of the control and first experimental groups had the same dynamics of reliable changes in sperm motility during four-hour incubation after thawing – a statistically significant decrease in the number of progressively moving sperm by 1.6 times (p < 0.05 – control group, p < 0.01 – first experimental group), and, on the contrary, a reliable increase in the number of non-progressively moving sperm by 1.3 times (p < 0.05 for both groups). Pronounced motility activity was observed in the sperm of the first experimental group upon completion of 4-hour incubation, equal to 21.45 ± 4.58%. The highest number of viable spermatozoa was registered in the first experimental group with 4-hour incubation of samples with MSC obtained from bone marrow - 37.13±2.21%, the highest number of spermatozoa with intact acrosomes - in the second experimental group (MSC AT). Thus, it can be assumed that MSC has a regenerative effect on the structure of spermatozoa after cryopreservation. To reveal the mechanism of the effect of MSC on the structure of spermatozoa, it is necessary to continue research.
POPULATION-GENETIC CHARACTERISTICS OF CATTLE BY THE MC4R (MELANOCORTIN 4 RECEPTOR) GENE
Authors: Safina N. Yu. , Krupin E. O.
Published: January 2025

The aim of the work was to provide a population genetic characteristic of the Kholmogorsky breed of the Tatarstan type of the Republic of Tatarstan for the MC4R gene (melanocortin 4 receptor). As a result of genotyping by the PCR-RFLP method for the MC4R - HpySE526I gene locus, 2 alleles and 3 genotypes were identified. The frequency of alleles: C - 0.434 and G - 0.566; and frequency of genotypes: CC - 20.9, CG - 45.0 and GG - 34.1%. The chi-square test (χ²) showed that the studied population the Hardy–Weinberg genetic equilibrium is not disturbed. A negative Selender coefficient (D) indicates outbreeding in the population. Monitoring of works on studying the polymorphism of the gene 1069C˃G (Leu286Val) shows a significant variability in the ratio of polymorphic forms of the MC4R gene in different cattle populations depending on their geographic and breed affiliation. On average, for all the considered cattle breeds of the world populations, the frequency of alleles of the MC4R gene is 0.537 and 0.463 for the allele C and G, respectively. The ratio of the CC, CG and GG genotypes of the MC4R gene for all analyzed cattle populations averaged 32.5, 42.3 and 25.2%. The analysis carried out using the data of foreign scientists and the results obtained in our study characterizes the world populations of cattle as genetically biodiverse, possessing genetic polymorphism for the MC4R gene with a high degree of heterozygosity. This research was supported by FASO Russia project, registration number 122011800138-7.
The study of the biological properties of the causative agent of hemorhagic enteritis of turkeys
Authors: Kraskov D. A. , Javadov E. D. , Veretennikov V. V. , Tarlavin N. V. , Sidorenko K. V.
Published: January 2025

Turkey breeding in the Russian Federation has a positive development trend, this is due to many useful qualities of meat. In addition to the positive aspects of the development of the turkey breeding industry, there are also negative ones, for example, as poultry farms in the turkey breeding sector develop and increase, the risks of infectious diseases increase, the most relevant for industrial turkey breeding is the prevention of dangerous diseases (OIE list) - Newcastle disease (NB), avian influenza (AI) and economically significant diseases of turkeys - hemorrhagic enteritis of turkeys (HE), infectious avian encephalomyelitis (AE), respiratory mycoplasmosis and mycoplasmic synovitis caused by Mycoplasma gallisepticum (MG) and Mycoplasma meleagridis (MM). The most common and economically dangerous disease is hemorrhagic enteritis of turkeys, unfortunately in the Russian Federation this disease is poorly studied. Therefore, it is necessary to direct research to the study of the biological properties of the virus, which will help to create diagnostic kits and means of specific prevention. That is why the purpose of our work is to study the biological properties of the HE virus. This set of studies includes: studying the concentration of the virus in target organs, macroscopic changes in organs, maternal immunity using the example of the half-life of antibodies to hemorrhagic enteritis. As a result of the conducted studies, data on macro and microscopic changes were obtained, the concentration of the virus was determined on various days after infection with RDP, and the halflife of maternal antibodies was determined. All these results will form the basis for the development of diagnostic tools and specific prevention in the future.
POSTOPERATIVE COMPLICATIONS IN ABOMAZOPEXY IN HIGHLY PRODUCTIVE COWS
Authors: Plemyashov K. V. , Semenov B. S. , Kuznetsova T. Sh. , Khusainova G. S. , Krutikova A. A. , Belikova A. O. , Nikonova T. O.
Published: January 2025

Displaced abomasum in cattle is a fairly common pathology, which occurs at different times after calving cows. According to the domestic authors, displaced abomasum in cattle at the dairy farming occurs in 1.5- 7% of the livestock. The domestic literature on treating displaced abomasum in dairy cattle provides limited and homogenous information on post-operative complications. The study was conducted for 4 years on 163 cows with a left-displaced abomasum or right-displaced abomasum that was repositioned and fixed in place with an incision in the right paralumbar fossa. The work took place on one of the farms in the Leningrad region. Native Holsteins of the domestic breed were kept untied in conditions of dairy complex. The total herd size is 1200 cows. Average cow milk production in the last 4 years was 11250 kg per year. During 4 years 163 cows with an operated displaced abomasum were clinically observed for the development of possible postoperative complications. The observation showed that 17 cows (10.42% of the operated animals) had postoperative complications in this period of time. Eight animals have developed purulent inflammatory complications diagnosed 20- 45 days after surgery. Three cows were found to have abscesses within 7-10 days of surgery. Hematoma was discovered in one cow 4 days after surgery. Four animals (2.45%) had a displaced abomasum’s reoccurrence among 163 cows in four years of observation.
Synthesis of Bis-(N-glucosylated triazolodithiadiazinyl) alkanes using N-Glucosylated Sulfenyl Chloride Reagent
Authors: Chavan Snehal , Berad Baliram , Ulhe Avinash , Waghe Prajakta
Published: January 2025

Methodology is reported for the synthesis of a six-membered heterocyclic ring involving cyclocondensation reaction through sulfur-sulfur bond formation. This method of synthesis allows for developing a new class of dithiadiazines. A series of bis-[6-tetra-O-acetyl-β-D-glucopyranosylimino-1,2,4-triazolo[3,4-b]-1,2,4,5-dithiadiazin-4-yl] alkanes have been synthesized by using a reagent, tetra-O-acetyl-β-D-glucopyranosylimino chloromethane sulfenyl chloride and bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes. These newly formulated N-glycosylated molecules could serve as a potential biological entity.
Benzotriazole and its derivatives: A comprehensive review of its synthesis, activities and applications
Authors: Kshatriya Monika R. , Gajjar Jinal A.
Published: January 2025

Benzotriazole, commonly referred to as BTAH, has garnered significant interest across several scientific disciplines due to its outstanding characteristics and wide-ranging applications. This document provides a concise overview of benzotriazole and its use in challenging corrosion scenarios. Furthermore, we emphasize the versatility of this molecule and the extensive research commitment associated with it. This thorough analysis examines the synthesis of benzotriazoles and their derivatives in-depth and encapsulates the numerous methods involved. Additionally, we conducted a thorough analysis of toxicity studies and the pertinent implications of benzotriazoles on human health, marine life, and the ecosystem. Our purpose is to provide readers with a thorough understanding of the potential dangers of this chemical by undertaking an extensive examination of associated risks and bad effects. During this review, we emphasize significant research discoveries and trends, offering useful insights into the current status of benzotriazole research and its future potential. The development of such research advances from 2010 to 2024.
Molecular docking against Covid-19 and HIV, and the role of catalysis in stereoselective cycloaddition reactions: A theoretical investigation of TiCl4-promoted reactions between cyclopenta-1,3-diene and benzyl acrylate/benzyl 2-fluoroacrylate
Authors: Idrissi Khadija El , Zeroual Abdellah , Garmes Hocine
Published: January 2025

The study of cycloaddition reactions between cyclopenta-1,3-diene and benzyl-acrylate, as well as benzyl-2-fluoroacrylate with and without the catalyst (TiCl4), was conducted using MEDT. The results of the energy profiles suggest that these reactions are stereoselective, meaning that they favor the formation of certain stereoisomers over others. Furthermore, the addition of TiCl4 as a catalyst appears to enhance the selectivity of these reactions, which is in line with experimental observations. Additionally, a docking study was carried out to predict the effect of stereochemistry and the presence of specific atoms, such as fluorine, on their ability to bind to viral proteins responsible for SARS-Covid-19 and HIV. Moreover, the notable affinity of Ligand 4 for HIV renders it a pivotal contender for extended research, possibly paving the way for enhanced antiretroviral drugs. Similarly, the encouraging affinity demonstrated by Ligand 1 towards the Covid-19 protein highlights its promise for Covid-19 drug development.
Antioxidant activity, DFT-calculation, and docking of 5-amino-N-(3-di(per)fluoroalkyl-2-iodo-n-propyl)-1,2,3-triazole-4-carboxamides
Authors: Danyliuk Ivanna , Kemskyi Sergiy , Saliyeva Lesya , Slyvka Nataliia , Melnyk Dmytro , Melnyk Oksana , Dorokhov Victor , Vovk Mykhailo
Published: January 2025

Antioxidant activity of a series of previously described 5-amino-N-(iododi(per)fluoroalkyl)-1H-1,2,3-triazole-4-carboxamides 3a-r, their synthetic precursors 5-amino-N-allyl-1,2,3-triazole-4-carboxamides 1a-g, and their deamination products N-(3-di(per)fluoroalkyl-2-iodo-n-propyl)-1,2,3-triazole-4-carboxamides 4a-e was investigated in vitro using DPPH test and ascorbic acid as a standard reference. It was established that compounds 3a-r inhibit DPPH free radicals in moderate to high values (50.9–97.6%). The effect of substituents in the position 1 of the 1,2,3-triazole nucleus, fluoroalkyl groups and amino groups on the level of antioxidant activity was studied in detail. Reactivity and electrostatic surface potential were evaluated for the most active carboxamides 3a,g,r using the DFT method, and molecular docking was studied in the NADPH oxidase protein model.
Obstetric consequences of delivery of women are after assisted reproductive technologies
Authors: Kitsаk Olga
Published: January 2025

The objective:to learn influence of assisted reproductive technologies (ART) on the obstetric results of delivery.Materials and methods. Retrospective research in which 100 women were plugged with single fetation (1 group) and 50 was conducted, – with a multifetation after assisted reproductive technologies (2 groups).Results. Basic obstetric complications in a 1 trimester of pregnancy were: removing layer by layer of chorion in 22% at single fetation and 38% at a multifetation; the syndrome of overstimulation of ovaries took place in 5% women of a 1 group and 10% – in 2 groups; the involuntary breaking of pregnancy in a 1 trimester is marked in 9 (9%) patients with a single fetation and in 6 (12%) – with multifetation; principal reasons of the involuntary breaking of one pregnancy was pregnancy which does not develop – (5 from 9) and anembryony (4 from 9). Conclusions.Pregnancy for women after ART is characterized by high-frequency of obstetric complications, thus in all trimesters of pregnancy. At the estimation of frequency of different complications it should be noted higher level at a multifetation as compared to single fetation. By basic complication women after ART regardless of number of fetuses have miscarriage and premature births. The got results testify to the necessity of improvement of algorithm of diagnostic and treatment-and-prophylactic measures.Keywords:assisted reproductive technologies, pregnancy, births, complications.
Features of surgical treatment of the combined pathology of uterus without and with pelvic organ prolapse
Authors: Vazhova Hanna
Published: January 2025

The objective: increase of efficiency of surgical treatment of the combined pathology of uterus without and with pelvic organ prolapse on the basis of development and introduction of the differentiated approach the choice of method of operation.Materials and methods. By us the conducted analysis of results of surgical treatment 120 patients which are operated concerning the of high quality diseases of uterus and pelvic organ prolapse with the use of vaginal operative access. As a basic (base) operation to all patients was done vaginal hysterectomy. Distinctive features had variants of vaginal operations for the patients of different clinical groups. Distributing of patients on clinical groups it is done by us depending on indications for the hysterectomy, presence of concomitant pelvic organ prolapse (complicated and (or) by a stress incontinence of urine) and age of patients.Results. Using of the offered differentiated approach for surgical treatment of the combined pathology of uterus without and with pelvic organ prolapse allows to mark a considerable improvement in 96,7% patients, and 83,3% from them considered itself completely cured. Patients had a percent of positive results of surgical treatment (93,3%) most high without pelvic organ prolapse, what hysterectomy was executed only concerning the of benigh diseases of uterus and appendages with laparoscopic assistance.Conclusions. The results of the conducted researches fully confirm the necessity of the differentiated approach treatment of the combined pathology of uterus without and at presence of pelvic organ prolapse. Developed and inculcated by us an algorithm allows to obtain positive results both in early and in remote terms after an operation. Keywords:combined pathology of uterus, pelvic organ prolapse, surgical treatment.
Modern aspects of prognostication of obstetric and perinatal complications for primiparous
Authors: Semenyuk Andrey
Published: January 2025

The objective: to develop and inculcate tactic of prognostication of obstetric and perinatal complications for primiparous. Materials and methods. By material, that allows to build classifications for creation of the prognostic screening programs of obstetric and perinatal complications for primiparous, information appeared clinical-and-statistical research of motion of pregnancy, births, state of fetus and newborns in 400 primiparous. Prognostication of risk of obstetric and perinatal complications is basis of screening for a decision-making in relation to the change of tactic of conduct of pregnancy, births, grant of necessary help with the purpose of improvement of results of the first pregnancy and first births. In basis of prognostication of possible complications the fixed method of stepwise discriminant analysis, for the conduct of which fact sheets are used clinical-and-statistical research in relation to prevalence of gestational, maternity and perinatal complications for primiparous in intercommunication with the complex of factors which are studied.Results. By the method of stepwise discriminant analysis the most significant criteria of prognosis were selected (parity; growth; age; age of menarche woman; a term of pregnancy is at the debut of placenta disfunction; a middle estimation is for Fisher; a ball estimation of deceleration is for cardiotokogram; a concentration of hormones is at the end of the III trimester of pregnancy; a systole-diastolic ratio is in 36-40 weeks; estimation new-born after a scale Apgar on the first and fifth minutes of life of risk of realization and development of obstetric and perinatal complications for primiparous.Built functions of discriminants, which with authenticity from 59,6 to 92,88% allow to define the risk of realization of placenta disfunction, development of discoordinated labor and fetal distress at the first births. Conclusions. It is got by us results allow to recommend the developed algorithm for introduction in the practical guard of health.Keywords:motion of pregnancy and births, primiparous, complications, prognostications
X y el discurso de figuras políticas mediante modelado de tópicos: campaña presidencial y covid-19 en Colombia
Authors: López-Ponce Marcela , Sánchez-Gonzáles Hada , Barredo-Ibáñez Daniel
Published: January 2025

X se ha convertido en la plataforma de debate político adoptada por candidatos presidenciales para posicionar sus marcas personales y difundir ideales políticos. En Colombia, durante la campaña presidencial y la pandemia de covid-19 existieron posiciones políticas extremas entre los candidatos de derecha e izquierda, Iván Duque y Gustavo Petro, respectivamente. La investigación analizó el contenido temático de sus publicaciones durante la campaña electoral a la presidencia de 2018, así como en el primer año de la pandemia de covid-19, en 2020, con el fin de estudiar y comparar los discursos. Se analizaron 9.395 tuits y 311.654 palabras de ambas cuentas oficiales en X. La metodología utilizada, no experimental, con un enfoque descriptivo, de corte cuantitativo, se basó en un análisis de contenido informatizado operado mediante el modelado de tópicos, que no incluye información sobre la interacción con los seguidores. Los resultados muestran una marcada diferencia de ejes temáticos entre derecha e izquierda, en donde, por un lado, los líderes estudiados publicaron contenidos relacionados con propuestas y soluciones de gobierno y, por otro lado, se encontraron indicios de una estrategia de polarización que buscaba el descrédito de la contraparte mediante su afianzamiento como interlocutor principal.
A Pharmacokinetic Comparison of Three Butyrate Products
Authors: La Monica Michael , Kirby Trevor , Hartshorn Shelley , Gustat Ashley , Grdic Jodi , Sandrock Jennifer
Published: January 2025

Introduction: The aim of this study was to compare the pharmacokinetic (PK) parameters of lysine butyrate (LysB) to sodium (NaB) and tributyrin (TB).
Methods:  Ten men (29.1 ± 10.4yr) completed this randomized, three-arm, crossover clinical trial (#NCT06700785) over four visits (a screening and three testing visits). Serum butyrate and indices of affect (well-being, calm/relaxed, stressed/anxious, mood, motivation to perform tasks, alertness, and concentration) were measured prior to product ingestion, and 20-, 45-, 90-, 150-, and 210-min post-ingestion. Each butyrate product delivered a total amount of 786 mg of butyric acid.
Results: There was a trend for an interaction (p=0.095) for serum butyrate concentrations, however there were no post hoc differences over time or between treatments. NaB (144±214µg/mL/min, p=0.042, d=0.75) and LysB (189±306µg/mL/min, p=0.023, d=0.86) had a significantly greater AUC0-210 than TB (108±190µg/mL/min). NaB (2.51±4.13µg/mL, p<0.001, d=1.66) and LysB (4.53±7.56µg/mL, p=0.007, d=1.11) had a significantly greater Cmax than TB (0.91±1.65µg/mL). NaB (22.5±7.91min, p=0.008, d=1.21) and LysB (20.0±0.0min, p=0.004, d=1.45) had a significantly lower Tmax than TB (51.5±21.7min). There was a main effect of time for well-being (p=0.005), calm and relaxed (p=0.013), mood (p=0.002), motivation to perform tasks (p=0.040), alertness (p=0.035), and a treatment trend for concentration (p=0.063) while there were no differences between treatments over time for stressed and anxious (p>0.10).
Conclusions: This study is among the first to simultaneously evaluate three commercially available butyrate formulations in a controlled setting, which may help inform formulation-specific therapeutic strategies in the future. This PK study demonstrates that LysB and NaB exhibit greater bioavailability and more rapid systemic appearance compared to TB.
El Sistema Penitenciario Ecuatoriano: Un análisis crítico del Régimen de Rehabilitación Social
Authors: Alvarado Moncada Zoila Felicita
Published: January 2025

Esta investigación tuvo como objetivo analizar de manera crítica el régimen de rehabilitación social establecido dentro del sistema penitenciario en Ecuador, evaluando los procedimientos, requisitos y principios que rigen estos regímenes en el cumplimiento de las condenas, y su impacto en la inserción adecuada de los privados de libertad en la sociedad. Este estudio utilizó un enfoque cualitativo y exploratorio mediante un análisis dogmático-jurídico y la hermenéutica jurídica para examinar en profundidad la normativa ecuatoriana relacionada a la temática abordada, empleando el método inductivo-deductivo, a través de los cuales se interpretó la legislación y la doctrina revisada. El análisis desarrollado permitió conocer que el proceso de resocialización y reinserción social Ecuador, enfrenta importantes desafíos en su implementación, como la sobrepoblación, la corrupción y la insuficiencia de recursos. A pesar de un marco normativo que enfatiza el respeto a la dignidad humana y la reintegración, estos problemas comprometen su efectividad y dificultan el logro de los objetivos de reducción de reincidencia y fortalecimiento de la seguridad pública. Por estas razones, las conclusiones de este estudio sugieren la importancia de implementar un enfoque integral y sostenible que permita la implementación de mecanismos para impulsar la reinserción social. Esto implica no solo la mejora de las condiciones materiales, sino también una transformación cultural y organizativa que priorice el respeto a los derechos humanos y la inclusión social como pilares de un sistema de justicia más eficiente.
Enfermagem humanizada: impactos no cuidado ao paciente e sua relevância no contexto social da saúde
Authors: Galvão Roberta das Graças Bezerra
Published: January 2025

A enfermagem humanizada representa uma abordagem essencial no cuidado à saúde, centrada na promoção da dignidade humana, empatia e respeito à individualidade do paciente. Este estudo analisou os impactos da humanização no cuidado ao paciente e sua relevância no contexto social, evidenciando benefícios significativos, como a melhoria dos resultados clínicos, a redução de reinternações e a promoção de bem-estar físico e emocional. Também foram discutidos os desafios enfrentados pelos profissionais de enfermagem, como a sobrecarga de trabalho e a falta de recursos, e as perspectivas para a ampliação dessa prática, incluindo capacitação profissional e políticas públicas. Conclui-se que a enfermagem humanizada é indispensável para a construção de um sistema de saúde mais justo, inclusivo e eficaz, com benefícios que transcendem o cuidado individual, alcançando a coletividade.
O novo ensino médio e seus impactos no processo educacional
Authors: Paludo Fábio Rodrigo , Gonçalves Rita de Cássia
Published: January 2025

Este artigo tem como objetivo analisar como a Base Nacional Comum Curricular (doravante, BNCC) e a Reforma do Ensino Médio, instituídas pela Lei número 13.415/2017 representaram mudanças estruturais significativas na educação brasileira, no intuito de flexibilizar o currículo e priorizar o desenvolvimento de competências. A proposta permite que os estudantes possam escolher diversas áreas de aprofundamento (itinerários formativos), como Linguagens, Matemática, Ciências da Natureza, Ciências Humanas ou uma Formação Técnica. Com isso, visa-se alinhar a educação brasileira aos desafios que foram apresentados no século XXI, especialmente no que tange às transformações no mercado de trabalho e nas relações sociais, incentivando habilidades de pensamento crítico e de resolução de problemas. Este estudo carateriza-se como uma pesquisa bibliográfica e os resultados indicam que as referidas propostas enfrentam obstáculos, como desigualdades regionais, infraestrutura precária em muitas escola e formação insuficiente de professores. Além disso, há preocupações sobre possíveis retrocessos, perda de autonomia docente e aprofundamento das desigualdades educacionais.
Impact on sales of basic items during the Covid-19 pandemic in local supply chain
Authors: Longhini Tatielle Menolli , Magalhães Luiz Cláudio Nunes , Ferreira Roberta de Amorim
Published: January 2025

The Covid 19 pandemic caused global social, economic, and political impacts, including significant changes in the sales of consumer goods, the focus of this study. Using data from a food product distributor, the study analyzed the sales volume of industries before and during the pandemic. Companies with different profiles were selected to contrast realities. Semistructured interviews with industry representatives, the distributor, and final customers revealed how the pandemic period affected consumer goods sales across various links in a local supply chain. After the first Covid 19 death in february 2020 and the World Health Organization (WHO) declaration of a pandemic in march, panic buying of basic items was observed, influenced by the intensified flow of information on social and mass media. Social isolation measures altered demand patterns and behavior, impacting the supply chain, which faced supply difficulties and had to adopt technological innovations and changes in work routines. These adaptations strengthened the relationship between suppliers, industries, distributors, and customers. Economic circumstances and social incentives affected consumer behavior, market practices, and prices. The study demonstrated that the pandemic significantly influenced the sale of consumer goods, highlighting the need for resilience and adaptation in supply chain operations.
Caracterização de propriedades físicas e anatômicas de clones de Eucalyptus spp. para a aplicação de agentes preservantes
Authors: Gomes Gabriele Silva , Galvão Weslaine Rodrigues , Souza Argel Costa , Morais Railton Oliveira , Santos Rafael Silva dos , Amorim Sandra Maria Carvalho Silva , Lima Michael Douglas Roque , Raabe Joabel
Published: January 2025

O presente trabalho teve como objetivo avaliar propriedades físicas e anatômicas da madeira de clones de Eucalyptus spp. utilizados na indústria de madeira tratada. A pesquisa foi realizada com dois clones (A e B) de 4 anos de idade, cultivados em espaçamento de 3 x 2 m. Foram abatidas 3 árvores por clone e delas foram retiradas amostras em forma de discos. Foram retirados 3 discos por árvore, em três posições ao longo da tora (base, porção central e topo). As propriedades avaliadas foram: densidade básica (Db), relação cerne alburno (C/A), morfologia dimensional das fibras (comprimento, diâmetro total, diâmetro do lúmen e espessura da parede) e o diâmetro de vasos. O delineamento estatístico foi inteiramente ao acaso em arranjo fatorial 2x3 (dois clones e três posições). Os dados foram analisados em programa estatístico.  A análise de variância mostrou que não houve interação significativa entre os fatores (clone x posições) para todas as variáveis físicas analisadas, evidenciando consistência nas características de cada clone. As propriedades físicas não variaram entre os clones e nem entre as posições. A densidade básica média foi de 0,48 g.cm-³, similar a espécies comerciais brasileiras de idade equivalente, enquanto a relação C/A média foi de 0,67, considerada baixa devido à idade das árvores, que apresentam mais alburno e menos cerne. Quanto às propriedades anatômicas, os clones diferem entre si, mas não houve diferença significativa entre as posições de amostragem ao longo do tronco. O Clone A apresentou maiores médias em relação ao diâmetro total da fibra (19,75 µm) e espessura da parede (4,8 µm), enquanto o Clone B exibiu maior comprimento das fibras (1080 µm) e maior diâmetro dos vasos (134,1 µm), sendo este último mais indicado para a aplicação de agentes preservantes. Ambos os clones demonstram potencial para a indústria de madeira tratada.
Electrocardiography with high resolution and digital processing for the non-invasive detection of low amplitude potentials
Authors: Cunha Naelso Alves , Inocêncio Ana Vitória de Morais , Florentino Gabriel Inácio , Albuquerque Afonso Luiz Tavares de , Rodrigues Marco Aurélio Benedetti , Silva Malki-cedheq Benjamin Celso da
Published: January 2025

Cardiovascular diseases represent the primary cause of mortality in contemporary society. However, the majority of these conditions can be effectively diagnosed at an early stage through the use of Electrocardiography (ECG). ECG with high resolution, recorded from the body’s surface, has the capability to detect subtle intracardiac potentials with low amplitude, thereby reducing the need for invasive diagnostic procedures. Enhanced resolution in ECG acquisition enables the generation of more detailed signals, which increases the potential for identifying additional features compared to conventional methods. This study introduces a platform employing a 24-bit analog-to-digital converter for real-time acquisition of ECG signals. These signals are transmitted to a web-based system for subsequent processing and analysis. The research aims to validate the technological feasibility of acquiring ECG signals at 24-bit resolution, facilitating immediate clinical interventions and providing a foundation for future investigations. A prototype device was tested by capturing patient ECG signals, which were processed using advanced filters to identify key areas of clinical relevance.
Covid-19: um vírus do e no Antropoceno
Authors: Faenello Daniele
Published: January 2025

O surgimento do vírus Sars-Cov-2 foi apontado pela comunidade científica como uma zoonose relacionada ao comportamento humano exploratório em relação ao meio ambiente Ações humanas, como o desflorestamento de grandes áreas para o avanço de fronteiras agrícolas, o tráfico de animais exóticos, a extinção de espécies vegetais e animais, o consumo não regulamentado de animais selvagens, a produção agropecuária crescente para atender (a priori) à demanda alimentícia, e a perda de biomas e biodiversidade, são intervenções cujas consequências provocam alterações ecológicas profundas no Sistema Terra, colocando a espécie humana como agente facilitador do surgimento de novas pandemias. Este ensaio propõe uma reflexão sobre o surgimento da Covid-19 e a possibilidade de novos vírus surgirem no contexto do Antropoceno, período marcado pela intensa influência humana sobre o planeta. A análise busca abordar a importância de um debate político sobre o papel dos governos, das instituições e do setor privado na criação de políticas públicas eficazes. O foco está em ações de prevenção ao colapso ambiental, que, por sua vez, podem ajudar a evitar o aparecimento de novos patógenos. O artigo destaca a urgência de reconsiderar o modelo de consumo e o foco no individualismo, defendendo uma mudança de paradigma em direção à valorização da coletividade e à promoção da segurança de toda a população.
Atividade anticâncer da própolis e seus compostos bioativos em câncer oral: uma revisão integrativa da literatura com análise bibliométrica
Authors: Vasconcelos Matheus Bastos , Silva Mayron Guedes , Silva Raphael Guedes , Sousa Klícia Kallynne Cutrim , Martins Diego Muniz , Machado Juliana Cristina do Nascimento , Pires Abigail Andrade , Sousa Franklin Monteiro de , Ribeiro Rachel Melo , Borges Marilene Oliveira da Rocha
Published: January 2025

Compostos derivados de produtos naturais surgem como uma alternativa terapêutica para o tratamento de câncer. Nessa perspectiva, essa revisão integrativa da literatura com análise bibliométrica tem como objetivo investigar os principais componentes bioativos da própolis que apresentam atividade anticâncer em células de câncer oral. As buscas eletrônicas foram realizadas nas fontes de informação MEDLINE via PubMed, LILACS e SciELO. Após aplicação dos critérios de elegibilidade, quatorze artigos foram incluídos nesta revisão. Extratos etanólicos e hidroalcóolicos, assim como os compostos bioativos Éster Fenetílico do Ácido Cafeico (CAPE), Artepillin C e Crisina foram os principais agentes anticâncer derivados da própolis descritos na literatura. Esses compostos demonstraram inibição do crescimento celular por meio da modulação de vias de sinalização como Akt, FAK e MAPK, além de induzirem apoptose através da regulação de proteínas pró-apoptóticas como Bax, Puma e caspase-3. Os extratos de própolis, independentemente de sua origem, também apresentaram efeitos anticancerígenos, com citotoxicidade seletiva em células tumorais e baixa toxicidade em células saudáveis. Portanto, os resultados deste estudo demonstram o potencial farmacológico anticâncer destes compostos bioativos da própolis e a necessidade de estudos clínicos para validar sua eficácia e segurança em humanos.
PREVALENCE OF ERECTILE DYSFUNCTION AFTER PELVIC RADIOTHERAPY
Authors: ANWER RA , BASHIR A , SHER HF , MANAN A , AMMARA A
Published: January 2025

Erectile dysfunction (ED) is a common complication among male cancer survivors undergoing pelvic radiotherapy, significantly impacting their quality of life. Despite its high prevalence globally, data on ED among Pakistani cancer survivors remain limited. Objective: To determine the prevalence, severity, and associated risk factors of ED among male patients undergoing pelvic radiotherapy at Nishtar Medical University and Hospital, Multan. Methods: This prospective observational study included 50 male patients aged 50–85 years undergoing pelvic radiotherapy for malignancies. Baseline and six-month follow-up assessments of erectile function were conducted using the International Index of Erectile Function (IIEF-5) questionnaire. Factors associated with ED, including age, comorbidities, and treatment parameters, were analyzed using SPSS version 26.Results: The prevalence of ED six months post-radiotherapy was 61%. Advanced age (≥65 years) and diabetes were significant risk factors, with 71.4% and 88.9% of patients, respectively, developing ED. Moderate and severe ED accounted for 42.9% and 35.7% of cases, respectively. Cultural stigma and limited healthcare resources were additional barriers to managing ED in the Pakistani context. Conclusion: ED is highly prevalent among male patients undergoing pelvic radiotherapy, with advanced age and diabetes being significant contributors. These findings underscore the need for routine ED screening, culturally sensitive counseling, and targeted interventions to improve the quality of life for cancer survivors in Pakistan.
Текущее состояние изучения ментальных моделей пользователя компьютерных систем
Authors: Журавлев Артем
Published: January 2025

Термин «ментальная модель пользователя» чаще всего рассматривается когнитивной психологией в рамках человеко-компьютерного взаимодействия. Целью данной статьи является проведение академического обзора классических и современных исследований, направленных на изучение фундаментальных свойств ментальной модели пользователя. Эта работа поможет систематизировать знания о теории ментальных моделей пользователя и ее ключевых отличиях от других когнитивных моделей, используемых в области когнитивной психологии и человеко-компьютерного взаимодействия. В статье будут рассмотрены основные подходы к выявлению ментальных моделей пользователя, их преимущества и недостатки, а также основные направления фундаментальных исследований данного концепта.
Методика «Стратегии родительской поддержки» в диагностике детско-родительского взаимодействия
Authors: Агеева Антонина
Published: January 2025

В статье раскрывается актуальность исследований стратегий родительской поддержки детей в трудной ситуации. Описывается методика «Стратегия родительской поддержки» и процедура ее валидизации, которая проводилась на выборке из 235 человек, на основе независимых экспертных оценок и корреляционного анализа с данными опросника И.М. Марковской «Взаимодействие родителя с ребенком» (ВРР) и методики изучения родительских установок (PARI) Е.С. Шефер, Р.К. Белл, адаптированной Т.В. Нещерет. Показана надежность и конвергентная валидность методики.
Функциональная грамотность как мера интеллекта: новые эмпирические свидетельства
Authors: Колачев Никита , Новиков Игорь
Published: January 2025

Работа направлена на изучение возможности интерпретации результатов тестирования по функциональной грамотности в терминах оценки интеллекта. В исследовании приняли участие студенты первого курса одного из вузов г. Москвы (n = 150). Для оценки функциональной грамотности использовались задания из открытого банка заданий, разработанных в рамках проекта «Мониторинг функциональной грамотности учащихся», для оценки невербального интеллекта — прогрессивные матрицы Равена. Полученные результаты позволяют говорить о том, что операциональные определения «функциональная грамотность» и «интеллект» имеют высокую степень семантического сходства. Также было показано, что данные оценки функциональной грамотности лучше согласуются с бифакторной психометрической моделью, а выделенный на ее основе общий фактор (g-фактор) имеет умеренно-тесную корреляцию с измерением невербального интеллекта с помощью прогрессивных матриц Равена. Отмечается, что все результаты, взятые в совокупности, позволяют интерпретировать результаты оценки функциональной грамотности в терминах оценки общего фактора интеллекта.
Evaluating Advanced Plate Fixation Techniques for Distal Femoral Fractures in Elderly Patients
Authors: Ahmad Saad
Published: January 2025

Distal femoral fractures are a growing concern among geriatric patients due to osteoporosis and age-related fragility. This study evaluates the effectiveness of LOCKED COMPRESSION PLATES (LCPs) in the surgical management of these fractures. Fifty elderly patients with fractures classified by the AO system underwent LCP fixation at Al-Beida Medical Center. Outcomes included radiological union, functional recovery assessed by the Knee Society Score (KSS), and complication rates. Radiological union was achieved in all cases within an average of 12.7 weeks. Functional recovery was excellent for Type A fractures (KSS 93), satisfactory for Type B (KSS 88), and moderate for Type C (KSS 80). Complication rates were low (10%), with no cases of nonunion or deep infection. LCPs offer biomechanical stability and promote early mobilization, making them effective for managing osteoporotic distal femoral fractures. Further studies are needed to compare their performance with other fixation techniques.
Restoring Dilapidated Buildings Using Grey Cooperative Games and the fair Distribution of Costs Between the Participating Companies
Authors: Emad Qasim  , Fathi Emharb  , Idris Abdulhamid
Published: January 2025

This paper shows that grey cooperative game theory can help us determine a fair cost between local and international companies to support the problem of restoration, maintenance or even reconstruction of dilapidated housing by using facility location games under uncertainty. Restoration, maintenance, or even reconstruction of dilapidated housing may be a means that must be accomplished before a disaster occurs as pre-emptive planning in order to contribute to better reconstruction and recovery, as well as insuring the lives of residents. In our study, we relied on the old and dilapidated residential quarters in Al-Bayda city. As an example, in our paper, we chose two residential quarter: Red Buildings quarter and White Buildings quarter, as these two quarters are exposed to a disaster that could happen at any moment, God forbid. Some photographs of these dwellings were taken, and they clearly show their deterioration and that they may be on the verge of collapse at any moment (See section 4). Therefore, we will help in restoring and maintaining them through this paper, and two companies will be chosen, one local and the other foreign, for the work for Maintenance and restoration. We will use cooperative grey game theory to help us to restore dilapidated buildings using grey cooperative games and the fair distribution of costs between the participating companies to support this problem using facility location games under uncertainty.
A Review of Contemporary Theories of Supply Chain Management and Its Application
Authors: Emmanuel Ampong Afoakwah , Kemevor Hannah , Koomson Elizabeth S. Boateng , Cyril Asase Komla
Published: January 2025

The purpose of this study is to identify current themes in supply chain management (SCM) and explore opportunities for SCM growth by examining theoretical perspectives in SCM. In order to map the application of theories in the Supply Chain Management sector, it conducts a review of the literature. We examine the main areas of SCM research, highlight important theories, and offer recommendations for future developments in the area. There has been little theory development in SCM, with a few well-known macro theories from other fields impacting the themes and conceptualization of Supply Chain Management that have been researched thus far. By using particular approaches, looking at less-studied elements of SCM, and testing novel frameworks, more theoretical advances could be made. Based on our assessment, we offer a thorough map of the most widely held theories in SCM and suggest future directions for the field’s advancement. A number of suggestions are offered to direct further investigation. This study represents a first step towards comprehending the development of Supply Chain Management theories and the conceptualization of SCM.
Cattle Fattening and Its roles in Socio-Economic Development of Fatteners: A Learning from Northern Part of Bangladesh
Authors: Shahen Md. Abu
Published: January 2025

Income-generating activities (IGAs) are the activities that are adopted to maintain the livelihood of people, particularly those who are marginalized and grassroots. IGAs also help to meet the daily needs of the doers by ensuring earnings through producing products. However, to explore the role of cattle fattening in improving the socio-economic status of the fatteners or farmers as IGA was the paper’s main objective. Mainly, the respondent’s survey with an interview schedule was used as the data collection method. Shibganj village was chosen purposively as the study area due to the prevalence of cattle fatteners reported. The study found that women were the major portion of the fatteners who were rearing and fattening cattle in separate rooms in their own house rooms in their own houses. Initially, they invested on average fifty thousand takas for purchasing cattle, and after rearing for a duration (average of six months), they sold the cattle to the local market. They were financially benefited by selling cattle, which also played a vital role in changing their social status. Almost all the fatteners opined that cattle fattening improved their social and economic conditions than before. Moreover, some problems were reported such as lack of emergency support for cattle, financial weakness of the fatteners, instability of price, and high-rate interest of loan.
Filter Based Sentiment Feature Selection Using Back Propagation Deep Learning
Authors: K Bhuvaneswari
Published: January 2025

Aim: The proposed Filter Based Sentiment Feature Selection (FBSFS) model focuses on to improve the performance of Sentiment Learning (SL) by selecting the most relevant sentiment features from text reviews using feature selection methods at document level.
Method: Sentiment Learning is applied at the document level for classifying text reviews into two categories either positive or negative. The key sentiment features adjectives (ADJ), adverbs (ADV), and verbs (VRB) which are essential for sentiment analysis, are extracted from text document using the WordNet dictionary. Feature selection is performed by applying four different algorithms: Information Gain, Correlation, Gini Index, and Chi-Square. These algorithms help identify the most significant features that contribute to sentiment classification. The selected features are then fed into a Back Propagation Deep Learning (BPDL) classification model for sentiment analysis.
Result: The experimental findings show that the proposed model achieved higher accuracy of 91.15% using Correlation feature selection. This accuracy signifies the effectiveness of the proposed model in classifying text reviews, outperforming other methods in terms of sentiment feature selection and classification.
Conclusion: The proposed model enhances the performance of sentiment learning by selecting the most relevant sentiment features, particularly those extracted from adjectives, adverbs, and verbs, and combining them with BPDL. The FBSFS model as a robust tool for sentiment classification.