bluuebunny/crossref_metadata_2025 huggingface dataset:
difícil encaje entre referéndum y democracia representativa : reflexiones desde España.
Authors: López González José Luis , De Santiago Montserrat
Published: March 2020

La participación política es esencial para caracterizar el ordenamiento jurídico como democrático (CE, arts. 9.2 y 23). El referéndum se configura como una modalidad del sistema español de participación política, complementaria de la democracia representativa, que es versátil para la adopción de decisiones de especial trascendencia y para la ratificación o la reforma de los textos constitucionales, previamente aprobados en las asambleas constituyentes.
Autoría mediata en estructuras de poder organizado y la responsabilidad del superior por omisión.
Authors: Daza Alfonso
Published: March 2020

Este artículo define la figura dogmática jurídica de la autoría mediata en su tercera categoría, que es la aplicable a las estructuras de poder organizado al margen de la ley, en las que rige una estricta categorización jerárquica, para entender su composición, la interpretación y la aplicación que se le da en la doctrina y en la jurisprudencia, delimitar su alcance y proponer alternativas para la resolución de problemas de imputación de los delitos cometidos por subordinados de los mandos de la organización, como lo es la responsabilidad del superior por omisión derivada de las reglas de guerra.
Panorama actual de la reelección presidencial : un análisis jurídico comparado dirigido a establecer el estado de la democracia.
Authors: Manzo Ugas Gustavo Alberto
Published: March 2020

En esta investigación se lleva a cabo un estudio sobre un aspecto fundamental del derecho constitucional: la reelección presidencial desde el punto de vista del derecho comparado. Se expone una revisión teórica y práctica de esta institución jurídica, sus características y elementos fundamentales, que se profundiza al hacer un análisis jurisprudencial comparado de diversos tribunales constitucionales y altas cortes en América. La inquietud científica se origina en la actualidad jurídica, con base en las premisas y los postulados de la figura del presidencialismo desmedido, que recurre en muchísimos casos al populismo y a la violación de la separación de poderes para continuar en el ejercicio del poder. El estudio comparado de la reelección presidencial permitirá determinar el sentido que tiene cada ordenamiento jurídico en uno de los aspectos más relevantes y que ocupa mayor espacio en la ciencia política y el derecho: la democracia.
Differential operators on almost-Hermitian manifolds and harmonic forms
Authors: Tardini Nicoletta , Tomassini Adriano
Published: March 2020

We consider several differential operators on compact almost-complex, almost-Hermitian and almost-Kähler manifolds. We discuss Hodge Theory for these operators and a possible cohomological interpretation. We compare the associated spaces of harmonic forms and cohomologies with the classical de Rham, Dolbeault, Bott-Chern and Aeppli cohomologies.
On the Convergence of the Elastic Flow in the Hyperbolic Plane
Authors: Müller Marius , Spener Adrian
Published: March 2020

We examine the L2-gradient flow of Euler’s elastic energy for closed curves in hyperbolic space and prove convergence to the global minimizer for initial curves with elastic energy bounded by 16. We show the sharpness of this bound by constructing a class of curves whose lengths blow up in infinite time. The convergence results follow from a constrained sharp Reilly-type inequality.
LncRNA ELFN1-AS1 promotes esophageal cancer progression by up-regulating GFPT1 via sponging miR-183-3p
Authors: Zhang Chunyan , Lian Hongkai , Xie Linsen , Yin Ningwei , Cui Yuanbo
Published: March 2020

Accumulating studies highlight the critical role of long non-coding RNAs (lncRNAs) in the development of various human cancers. Extracellular leucine rich repeat and fibronectin type III domain containing 1-antisense RNA 1 (ELFN1-AS1) was shown to be a newly found lncRNA that abnormally expressed in human tumors. However, till now the specific function of this lncRNA in esophageal cancer (ESCA) remains unknown. In this study, we discovered that higher ELFN1-AS1 expression indicated shorter patient survival in pan-cancer, including ESCA, using online The Cancer Genome Atlas (TCGA) tools. The lncRNA ELFN1-AS1 was significantly up-regulated in ESCA tissues and cell lines when compared with the counterparts. Down-regulation of ELFN1-AS1 restrained cell proliferation, migration, and invasion of ESCA in vitro. In addition, we found that the expression of microRNA-183-3p (miR-183-3p) and ELFN1-AS1 or glutamine-fructose-6-phosphate transaminase 1 (GFPT1) were inversely correlated in ESCA. Both ELFN1-AS1 and GFPT1 are direct targets of miR-183-3p in ESCA. The effects of ELFN1-AS1 knockdown on ESCA progression were partially rescued by inhibition of miR-183-3p or over-expression of GFPT1. In summary, the results of this study suggest that the lncRNA ELFN1-AS1 facilitates the progression of ESCA by acting as a competing endogenous RNA (ceRNA) to promote GFPT1 expression via sponging miR-183-3p.
The MICOS complex, a structural element of mitochondria with versatile functions
Authors: Khosravi Siavash , Harner Max E.
Published: March 2020

Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial dysfunction. This indicates strongly that mitochondrial architecture and function are intimately linked. Therefore, a deep knowledge about the determinants of mitochondrial architecture and their function on a molecular level is of utmost importance. In the past decades, various proteins and protein complexes essential for formation of mitochondrial architecture have been identified. Here we will review the current knowledge of the MICOS complex, one of the major structural elements of mitochondria. MICOS is a multi-subunit complex present in the inner mitochondrial membrane. Multiple interaction partners in the inner and outer mitochondrial membrane point to participation in a multitude of important processes, such as generation of mitochondrial architecture, lipid metabolism, and protein import into mitochondria. Since the MICOS complex is highly conserved in form and function throughout evolution, we will highlight the importance of MICOS for mammals. We will emphasize in particular the current knowledge of the association of MICOS with severe human diseases, including Charcot–Marie–Tooth disease type 2, Alzheimer's disease, Parkinson's disease, Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Clinical profile and care pathways among unaccompanied minor asylum seekers in Vaud, Switzerland
Authors: Genton Paul Camille , Wang Jen , Bodenmann Patrick , Ambresin Anne-Emmanuelle
Published: March 2020

Objectives

The objectives of this study were to describe the overall clinical profile (somatic and psychological health) and the care pathways of unaccompanied minor asylum seekers (UMAS) who arrived in the Swiss canton of Vaud in 2015.

Methods

This was a retrospective study based on information extracted from the medical files of 109 patients over 1 year of follow-up. All the reasons for consultation and referrals as well as the diagnoses made were noted and coded using ICD-10. The healthcare providers for all diagnoses and referrals were also noted.

Results

Our sample was predominantly male (87.2%) and hailed primarily from Eritrea (39.4%) and Afghanistan (32.1%). Gatekeeping nurses at a specialized migrant care facility (MCF) referred 67.7% of the UMAS to other providers for further medical care, including 45.4% to the Interdisciplinary Division for Adolescent Health (DISA). However, 46.8% of the 109 UMAS also sought care at other structures without any referral by MCF or DISA as intended. Of the patients 39.4% were found to have at least one mental health problem, mainly functional disorders (21.1%), symptoms and episodes of depression (17.4%), symptoms of post-traumatic stress disorder (PTSD) (13.8%) and sleeping disorders (12.8%). The most common diagnoses of infectious diseases included community-acquired respiratory infections (43.1%), scabies (20.2%) and cases of skin abscesses and furuncles (13.8%). In fewer instances, cases of active tuberculosis (3.7%), chronic hepatitis B (2.8%), intestinal parasites (1.8%) and gastritis caused by Helicobacter pylori (1.8%) were also diagnosed. A significant proportion of UMAS presented traumatological (30.3%) and ophthalmological (25.7%) problems. Among the female UMAS (12.8% of the sample), evidence of genital mutilation (21.4%), pregnancy (21.4%) and abortion (14.3%) was common.

Conclusions

An integrated approach involving efficient coordination between different providers is necessary in order to respond adequately to the major healthcare needs of UMAS. Special attention should be paid to mental health.
Manual physical therapy as a novel treatment modality for Autism spectrum disorder – A pilot study
Authors: Jungade Shyam
Published: March 2020

Background

Autism spectrum disorders (ASDs) fall under neurodevelopmental disorders and are characterized by impaired social interaction and communication, restricted interests, and repetitive behaviors. The current available treatments aim at functional rehabilitation with resultant partial improvement in few and the persistent handicap in rest of them. Manual physical therapy or manual manipulation therapy has the basis in structural rehabilitation of the patient and has been proposed to act by both peripheral and central mechanisms.

Case presentation

To study improvement in different components of ASD by manual physical therapy, the therapy comprised of soft tissue therapy, in the form of myofascial release (MFR) of deep fascia of leg and foot muscles. The child with ASD, treated by manual physical therapy had global improvement in all the deficits.

Conclusions

This is probably first case of autism reported to have almost complete symptom resolution, with any single form of treatment and this form of therapy holds promise in integrative and holistic management of the patient.
Crystal structure of 3-(2-methylbenzyl)thiazolidin-2-one, C11H13ONS
Authors: Lin Qiao , Lin Zirui , Chen Xiuwen , Li Bin
Published: March 2020

C11H13ONS, monoclinic, P21/c (no. 14), a = 8.0795(6) Å, b = 7.2294(5) Å, c = 17.5898(14) Å, β = 98.354(8)°, V = 1016.52(13) Å3, Z = 4, R
gt(F) = 0.0332, wR
ref(F
2) = 0.0825, T = 120.00(10) K.
The crystal structure of 2,2,2-trifluoro-1-(isoquinolin-1-yl)ethane-1,1-diol, C11H8F3NO2
Authors: Yi Qin , Zhu Xiong , Zhang Ji-Run , Zhou Zhi-Xu , Zhao Chun-Shen
Published: March 2020

C11H8F3NO2, monoclinic, P21/c (no. 14), a = 8.6599(8) Å, b = 11.6216(12) Å, c = 10.0903(9) Å, β = 93.393(2)°, V = 1013.73(17) Å3, Z = 4, R
gt(F) = 0.0352, wR
ref(F
2) = 0.0984, T = 273(2) K.
Noise metrics analysis in schools near airports: A Brazilian case study
Authors: Taufner Mariani Dan , Gama Ana Paula , Slama Jules Ghislain , Torres Julio Cesar Boscher
Published: March 2020

This study compares metrics for environmental noise diagnosis in schools at airport vicinity. The goal is to analyze and identify the most suitable criteria for scaling aircraft noise impact over schools, during landing and take-off operations. A Brazilian case study is conducted, based on the noise mapping and sound level verification. The day-night average noise level (DNL) and the time above limit (TA) are investigated using acoustic simulation and noise mapping and in order to identify the critical receivers. Results of DNL and TA for two schools at airport surroundings show that the criteria adopted by the municipal and airport authorities to describe the airport noise are unsatisfactory and do not reflect the intermittent behavior of this type of noise. It was verified that individual receiver analysis, based on noise interruptions thought TA parameter is more suitable for evaluation of noise impact over schools at airport vicinity.
Abandoned agricultural soils from the central part of the Yamal region of Russia: morphology, diversity, and chemical properties
Authors: Abakumov Evgeny , Morgun Evgeniya , Pechkin Alexandr , Polyakov Vyacheslav
Published: March 2020

The post-anthropogenic and soil cover transformations of former agricultural soils on the abandoned lands in the Russian Arctic territory are poorly investigated due to the active growth of the city complexes and increasing area occupied by agricultural lands. That is lead to an increase in the area of the arable lands surrounding the polar urbanized territories. Today, most of that land allocated for agricultural needs has been abandoned or affected by other types of land use. This study aimed to investigate the abandoned lands surrounding some of the settlements in the central part of the Yamal region. The soil diversity, morphology, and chemical and agrochemical properties were investigated with special reference to the specific transformations that occur to fallow lands under permafrost-affected cryogenic-ecosystem conditions. Analysis of data show that these soils are characterized by features relating to both, previous (and existing), anthropogenic impacts and natural processes such as cryogenic mass transfer. The degradation of the arable humus-enriched horizon was not as pronounced as it has been in more humid boreal environments over recent decades. The organic carbon content in topsoil depends on the land use and varied considerably among the soil types. The former arable topsoil horizon has been stable over time in terms of its morphological features and agrochemical state. Despite the high soil acidity levels, thenutrient content in the anthropogenically impacted soils was still high, even though being abandoned for 20 years.
Die internationale Ordnung: Bestandsaufnahme und Ausblick
Authors: Maull Hanns W.
Published: March 2020

Um die Entwicklung der internationalen Ordnung zu diagnostizieren, bedarf es zunächst einer präzisen Begrifflichkeit. Dieser Beitrag versteht die Weltordnung als spezifische Ausprägung politischer Ordnung, die eng verwoben mit nationalstaatlichen politischen Ordnungen funktioniert. „Die“ internationale Ordnung als umfassende Weltordnung ist ein relativ junges Phänomen, das dennoch bereits eine differenzierte historische Entwicklung aufweist. Die gegenwärtige, seit 1990 bestehende Weltordnung erfährt – nach einer Phase der Konsolidierung und der Expansion in den 1990er Jahren – etwa seit 2003 eine sich beschleunigende Erosion. Der Beitrag beschreibt die wesentlichen Charakteristika dieser Ordnung, erläutert die Ursachen der Erosions- und Zerfallsprozesse, die inzwischen ein gefährliches Ausmaß erreicht haben, und blickt auf die sich abzeichnende zukünftige internationale Ordnung.
Doppelte Wendezeit
Authors: Spohr Kristina
Published: March 2020

Die Welt veränderte sich dramatisch, als die Berliner Mauer fiel und Proteste zum Massaker auf dem Platz des Himmlischen Friedens führten. Basierend auf umfangreichen Archivrecherchen zeigt der Aufsatz, wie sich der revolutionäre Umbruch von 1989 in Europa und Asien abspielte und wie in der Folge eine neue internationale Ordnung geschaffen wurde – ohne größere Konflikte. Die Welt nach dem Mauerfall wurde in erheblichem Maße durch die entschlossene Diplomatie einer kleinen Kohorte internationaler Staatslenker geschaffen, die harte, aber kooperative Verhandlungen führten, um die Institutionen des Kalten Krieges neu zu erfinden. Nicht alle Beziehungen waren einfach, wobei eine tiefgreifende historische Skepsis vor allem Deutschland gegenüber bestand. Dennoch, in Partnerschaft und durch ihre Bündnisse, wollten sie alle eine bessere Welt aufbauen – eine auf gemeinsamen Prinzipien basierende internationale Ordnung. Um der Berechenbarkeit, der Stabilität und des Friedens willen beschlossen sie, die alten westlichen Institutionen, insbesondere die EG/EU und die NATO, die den Osten integrieren würden, zu bewahren, zu modifizieren und neu zu erfinden. Die Transformation Europas muss jedoch im globalen Kontext verstanden werden. Wenn man diesen Weg der Geschichte dem in Peking gegenüberstellt, wo Deng Xiaoping die Demokratiebewegung brutal unterdrückte, lässt sich zeigen, wie Deng China nach dem Tiananmen auf eine ganz andere Bahn brachte; eine, die das Reich der Mitte durch kommunistische Neuerfindung vom insularen maoistischen Entwicklungsstaat zur autoritativ-kapitalistischen Weltmacht geführt hat. Auf diese Weise erwiesen sich die Scharnierjahre 1989–1992 nicht als das Ende der Geschichte, sondern hatten klare Auswirkungen auf unsere Zeit: die Welt von Putin, Trump und Xi.
Den Westen neu denken. Wege aus der Krise der freien Welt
Authors: Kleine-Brockhoff Thomas
Published: March 2020

Nachdem ein viertel Jahrhundert lang die Annahme verbreitet war, die Welt strebe dem demokratischen Frieden zu, wähnen heute viele den Rechtspopulismus auf einem nicht zu stoppenden Siegeszug. Dieses lineare Denken rechnet mit dem (Hirn)-Tod der NATO, dem Ende des Westens und dem Zerfall der liberalen internationalen Ordnung. Statt sich dem Fatalismus hinzugeben, sollten die Freunde der Freiheit den Westen neu denken, indem sie die liberale Überdehnung der vergangenen Jahre hinter sich lassen und stattdessen einen bescheidenen und zugleich robusten Liberalismus entwickeln, der die Grundlage einer erneuerten Ordnung bilden kann.
Fritz Eisels Mosaik Der Mensch bezwingt den Kosmos am Rechenzentrum in Potsdam. Eine kunsthistorische Kontextualisierung von Ort, Werk und Rezeption
Authors: König Susanne
Published: March 2020

The subject of this essay is Fritz Eisel’s mosaic Der Mensch bezwingt den Kosmos (Humanity Conquers the Cosmos), a frieze that has decorated the Potsdam data-processing center since its completion in 1972. Composed of 18 panels measuring ca. 3 × 3 m, this frieze is unusually large, yet in its ideological appropriation of science and technology it is a paradigmatic example of public art in the German Democratic Republic. Framed by textual references to Einstein and Marx, Eisel’s mosaic glorifies the progress of industry, agriculture, and administration, but first and foremost of aviation and space flight. This essay examines the mosaic in the context of the “scientific-technical revolution” officially proclaimed in 1964, and with a view to its site, which is fraught with historical implications.
The symmetry principle of antiaromaticity
Authors: Berger Raphael J. F. , Viel Alexandre
Published: March 2020

Current definitions of aromaticity are purely phenomenological and relate symmetry, reactive stability and the occurrence of molecular diamagnetic response currents. The antithetical concept of antiaromaticity provides a connection between the contrary properties: structural instability or distortion out of higher symmetry, a small HOMO-LUMO gap, and paramagnetic response currents. We reveal the symmetry principle that is underlying antiaromaticity by showing an intimate and strict symmetry induced relation between these properties. The principle is mathematically rigorous and can be formulated like: First order (and related) Jahn-Teller distorted molecules out of non-cubic and non-icosahedral point groups are prone to induced paramagnetism in magnetic fields parallel to the main axis of symmetry. We show by the exemplary cases of cyclobutadiene, cyclcooctatetraene, pentalene and manganese trifluoride how this principle works and discuss this new perspective on antiaromaticity.
Queer(ed) Pedagogies: A Critical Perspective
Authors: Bauer Gero , Engelmann Sebastian
Published: March 2020

Current political controversies concerning progressive concepts of sex education in schools lead to an often openly aggressive dispute about the handling of identity concepts, understandings of gender, and knowledge in school and extracurricular contexts. In addition to general emancipatory concepts which emphasise diversity and tolerance, the discussion increasingly considers queer-theoretical interventions. This article outlines the axiological questions of a queer pedagogy, and offers insights into practices which might emerge as a result of such considerations. At the same time, it formulates theoretical questions of a queer pedagogy as they pertain to a more general theory of educational processes, and which concern not only the practice of teaching and learning, but also the formation of educational theory.
Numerical Investigation of Subcooled Boiling Heat Transfer in Helically-Coiled Tube
Authors: Haryoko Luthfi A. F. , C. Kurnia Jundika , Sasmito Agus P.
Published: March 2020

Subcooled boiling heat transfer in helically-coiled tubes offers better heat transfer performance than any other types of boiling processes due to its ability to capture high heat flux with a relatively low wall superheat. This study investigates turbulent subcooled forced convection boiling performances of water-vapour in a helically-coiled tube with various operating conditions i.e. operating pressure, heat, and mass flux. Developed CFD model is validated against previously published experimental results using the RPI model. The model is developed based on the Eulerian-Eulerian framework coupled with k-ε RNG turbulence model and Standard Wall-Function. A good agreement is found between numerical prediction and experimental counterpart for the bulk fluid temperature and non-dimensional length. The result indicates that the subcooled boiling heat transfer in a helically-coiled tube tends to improve heat transfer coefficient and pressure drop in the domain. Subcooled boiling starts at the inner side of the helically-coiled tube (f=9900) due to the existence of secondary flow that comes from the coil curvature. Heat transfer coefficient and pressure drop increased with increasing heat flux and decreasing mass flux, and operating pressure. This is caused by the bubble movement and convective heat transfer phenomena in a helically-coiled tube. Finally, this study can provide a guideline for future research of the subcooled boiling in a helically-coiled tube.
Research of a Truck Train Movement when Driving Semitrailer by Slowdowning of Wheels of One Axis Pin on the Model
Authors: Sakhno V. P. , Yashchenko D. M. , Marchuk R. M. , Marchuk N. M. , Lyashuk O. L.
Published: March 2020

A free-running model of a truck train, which simulates a truck train consisting of a tow truck MAN TGS 19.360 and a biaxial semitrailer Utility VS2DС with a steerable front axis, has been developed. A semitrailer model is active with the wheel drive enables to control its movement by slow downing one of the wheels. The model was equipped with all necessary control equipment. It proved that driving a semitrailer by slow downing one of its wheels is identical to driving a semitrailer front axis with direct drive and a driver transmission ratio of 0.5. Differences in all cases have not exceeded 12% that is slowingdown one of the wheels of a semitrailer is reasonable for driving a truck train with a long base semitrailer.
Cuticle Collagen Expression Is Regulated in Response to Environmental Stimuli by the GATA Transcription Factor ELT-3 inCaenorhabditis elegans
Authors: Mesbahi Hiva , Pho Kim B , Tench Andrea J , Leon Guerrero Victoria L , MacNeil Lesley T
Published: March 2020

Mesbahi et al. find that environmental factors, including diet, starvation, and population density can differentially influence the penetrance of collagen mutant phenotypes. Factors that decrease the penetrance of rolling in dominant...

The nematode Caenorhabditis elegans is protected from the environment by the cuticle, an extracellular collagen-based matrix that encloses the animal. Over 170 cuticular collagens are predicted in the C. elegans genome, but the role of each individual collagen is unclear. Stage-specific specialization of the cuticle explains the need for some collagens; however, the large number of collagens suggests that specialization of the cuticle may also occur in response to other environmental triggers. Missense mutations in many collagen genes can disrupt cuticle morphology, producing a helically twisted body causing the animal to move in a stereotypical pattern described as rolling. We find that environmental factors, including diet, early developmental arrest, and population density can differentially influence the penetrance of rolling in these mutants. These effects are in part due to changes in collagen gene expression that are mediated by the GATA family transcription factor ELT-3. We propose a model by which ELT-3 regulates collagen gene expression in response to environmental stimuli to promote the assembly of a cuticle specialized to a given environment.
El Comité de derechos humanos y la presunción de inocencia: ¿Un derecho extraprocesal?
Authors: Hidalgo Flores Héctor Ivar
Published: March 2020

The Human Rights Committee has issued several legal opinions wherein it has analyzed the right to the presumption of innocence.  This United Nations body has unraveled the scope of this guarantee and, certainly, has brought to surface its multifaceted character.  However, much of its jurisprudence has focused on the extra-procedural aspect of this right.  Therefore, as the working hypothesis, it was formulated that the right to the presumption of innocence, from the interpretation of the Human Rights Committee, was a purely extra-procedural guarantee.  However, the investigation showed that although its jurisprudence has been characterized by conceiving this principle as a right that comes to life outside the legal process, it also contains other criteria that extend the scope of this legal institution.
Reported Polio cases in Pakistan during 2019
Authors: Ahmad Tauseef , Haroon Haroon , Hussein Musa Taha , Khan Muhammad , Baig Mukhtiar , Ning Feng
Published: March 2020

This report describes polio cases, vaccination uncertainty and challenges, and the way forward to eradicate polio from Pakistan. Numerous articles, government and non-government documents, and survey reports were studied and an online search was made to collect information on polio in Pakistan. Once again the polio vaccination program has been stopped and accused by the local community in Pakistan as a result an increase has been seen in polio cases in the last year. In 2019, a total of 117 wild poliovirus (WPV) and 18 circulating vaccine-derived poliovirus (cVDPV2) cases were reported from the country. The majority of cases were from the Khyber Pakhtunkhwa (KP) province as a result of polio vaccination uncertainty and many challenges faced by the vaccination program in the region. Pakistan reported their highest annual number of WPV cases as compared to last few years. This increase is not only an alarming threat for the country but also a key challenge for the global polio eradication movement. Increase awareness and raising immunization to over 100% in some areas especially in the remote area where every year many children missed vaccination to achieve global polio eradication goals.
Chronic Thrombocytopenia as the Initial Manifestation of STIM1-Related Disorders
Authors: Sura Anjali , Jacher Joseph , Neil Erin , McFadden Kathryn , Walkovich Kelly , Hannibal Mark
Published: March 2020

Pediatric thrombocytopenia has a wide differential diagnosis, and recently, genetic testing to identify its etiology has become more common. We present a case of a 16-year-old boy with a history of chronic moderate thrombocytopenia, who later developed constitutional symptoms and bilateral hand edema with cold exposure. Laboratory evaluation revealed evidence both of inflammation and elevated muscle enzymes. These abnormalities persisted over months. His thrombocytopenia was determined to be immune mediated. Imaging revealed lymphadenopathy and asplenia, and a muscle biopsy was consistent with tubular aggregate myopathy. Ophthalmology evaluation noted photosensitivity, pupillary miosis, and iris hypoplasia. Genetic testing demonstrated a pathogenic variant in STIM1 consistent with autosomal dominant Stormorken syndrome. Our case is novel because of the overlap of phenotypes ascribed to both gain-of-function and loss-of-function pathogenic variants in STIM1, thereby blurring the distinctions between these previously described syndromes. Pediatricians should consider checking muscle enzymes when patients present with thrombocytopenia and arthralgia, myalgia, and/or muscle weakness. Our case highlights the importance of both multidisciplinary care and genetic testing in cases of chronic unexplained thrombocytopenia. By understanding the underlying genetic mechanism to a patient’s thrombocytopenia, providers are better equipped to make more precise medical management recommendations.
Diversity of arbuscular mycorrhizal fungi communities associated with cape gooseberry (Physalis peruviana L.) crops
Authors: Ramírez-Gómez Margarita , Pérez-Moncada Urley , Serralde-Ordoñez Diana , Peñaranda-Rolón Andrea , Roveda-Hoyos Gabriel , Rodriguez Alia
Published: March 2020

The diversity of arbuscular mycorrhizal fungi (AMF) communities in agricultural systems depends on biotic and abiotic factors as well as on cultural practices. This research aimed to evaluate the diversity of AMF present in an altitudinal transect cultivated with cape gooseberry (Physalis peruviana L.). A set of 13 soil samples from cape gooseberry plantations located in the Colombian Andean mountains in the provinces of Cundinamarca and Boyaca were collected during dry (0-20 mm/month) and rainy (150-330 mm/month) seasons between 1500 and 3000 m a.s.l., in order to establish the relationship between the altitudinal characteristics and AMF diversity. The evaluation of the abundance of spores and species and diversity indexes showed the presence of 46 AMF species in the dry season and 31 in the rainy season. This shows the high diversity of AMF in the tropical Andes with spore abundance between 20 and 120 spores 10 g-1 of soil in the rainy season and between 127 and 1531 spores 10 g-1 of soil in the dry season.
Kinerja Keuangan Daerah dalam Rangka Pelaksanaan Otonomi Daerah di Indonesia
Authors: Heldi Heldi , Zelika Yori Zela
Published: March 2020

Pemerintah Kabupaten Bandung Barat telah menerima opini Wajar dengan Pengecualian (WDP) dalam Laporan Audit BPK (Badan Pemeriksa Keuangan) tentang Laporan Keuangan Pemerintah Daerah (LKPD) selama lima tahun berturut-turut, terhitung dari 2013-2017. Penelitian ini dilakukan dengan tujuan untuk mengetahui dan menggambarkan tingkat kinerja keuangan Pemerintah Daerah Kabupaten Bandung Barat (TA 2013-2017) dengan menggunakan rasio keuangan daerah, yaitu: 1) tingkat desentralisasi, 2) rasio ketergantungan daerah, 3) rasio kemandirian daerah, 4) rasio efektivitas pendapatan asli daerah (PAD), 5) rasio efisiensi pendapatan asli daerah (PAD). Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif, sedangkan teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan studi dokumentasi. Hasil penelitian ini menunjukkan bahwa: 1) tingkat desentralisasi menunjukkan persentase rata-rata 16,27% diklasifikasikan sebagai kurang, 2) rasio ketergantungan daerah menunjukkan persentase rata-rata 80,01% yang termasuk dalam kategori tinggi, 3) dalam rasio independensi daerah menunjukkan persentase rata-rata 21,82% yang termasuk dalam kategori konsultatif rendah, 4) rasio efektivitas PAD menunjukkan persentase rata-rata 100% diklasifikasikan sebagai efektif, 5) rasio efisiensi PAD menunjukkan persentase rata-rata 90,01% termasuk dalam kategori tidak efisien.
Управління безпекою харчування дітей
Authors: Коноваленко А. С.
Published: March 2020

Стаття присвячена висвітленню проблематики управління безпекою харчування дітей шкільно-го віку. Автором поставлено питання пошуку балансу державно-приватного партнерства з метою під-вищення рівня безпеки харчування, подано оцінку обмеження можливостей державного регулюванняцієї сфери та потенціалу застосування маркетингового механізму. Викладається наукова позиція дообґрунтування підхід до визначення таких станів безпеки харчування дітей, як критичний, відносний тагарантований рівні. Наведено розширений підхід до управління безпекою харчування дітей, у відпові-дності до якої роль державного регулювання полягає у забезпеченні подолання ризиків та загроз без-пеці харчування, а роль суб’єктів маркетингу полягає у використанні існуючого потенціалу підвищеннярівня безпеки харчування дітей до найвищого з можливих у певних умовах для досягнення рівня. По-дано характеристику функцій управління безпекою харчування дітей, як сукупності функціональнихзавдань, що розв’язуються поступово, послідовно та у їх взаємозв’язку відповідно до цілей підвищен-ня рівня безпеки харчування дітей.
Phytotoxic and dissuasive activity of Chihuahua desert plants
Authors: PEREZ-LEAL Ramona , TORRES-RAMOS Maribel , FLORES-CORDOVA Maria A. , GONZALEZ-FRANCO Ana C. , HERNANDEZ-RODRIGUEZ Adriana , SOTO-PARRA Juan M. , ROBLES-HERNANDEZ Loreto
Published: March 2020

With the purpose of finding plant compounds with the potential use as herbicides and insecticides, a research was realized with the objective of evaluate the phytotoxic and dissuasive activity of four Chihuahua desert plants. The phytotoxic activity evaluation was tested on Lactuca sativa and Lolium perenne, while the dissuasive activity was realized on three species of phytophagous insects: Myzus persicae, Rhopalosiphum padi and Spodoptera littoralis. Raw extracts were used, the solvents hexane, methanol and ethanol of different plants’ organs (root, steam, leaf and flower) of four species: Fouquieria splendens (ocotillo), Larrea tridentate (governor), Astragalus mollissimus (wild grass) and Pachycereus pecten-aboriginum (echo), by the establishment of in vitro bioassays at a concentration of 10 mg/ml extract/solvent. In the toxicity bioassay, the percentage of germination, root and leaf length were measured. The results showed that the leaf extract of L. tridentata had phytotoxic activity for L. sativa, while for L. perenne the phytotoxicity was observed within the ocotillo, governor and echo extracts. In the dissuasive bioassay, each treatment had 20 repetitions with 10 adult insects per repetition. The methanolic extracts of F. splendens leaf and root, ethanolic extract of A. mollisimus sheet and the ethanolic extract of P. pecten-aboriginum stems showed moderate dissuasive response of feeding against M. persicae, presenting a settlement inhibition index of 53.53, 54.35, 60.00 and 48.84% respectively. Nevertheless, the results indicated that none of the 10 extracts tested on S. littoralis showed significant dissuasive properties for this Lepidoptera, while for R. padi all the tested extracts presented dissuasive properties. The treatments of the four vegetable species evaluated showed defensive or dissuasive properties of moderate to strong feeding against the insects M. persicae and R. padi, presenting interesting potential for being used as insecticides, while the tested extracts that presented phytotoxicity for both lettuce and ryegrass present possibilities for the realization of herbicides.
Climate change effects on phytochemical compounds and antioxidant activity of Olea europaea
Authors: BEN MANSOUR-GUEDDES Samia , SAIDANA-NAIJA Dhouha , BCHIR Ameni , BRAHAM Mohamed
Published: March 2020

To tolerate water shortage and high temperature, olive cv. ‘Meski’, the main variety of table olives in Tunisia, developed several biochemical changes. The hereby study focused on the adaptation of the olive tree to the climatic conditions, considering the evaluation of phenolic compounds, chlorophylls, carotenoids, saponin and steroid synthesis, as well as the evaluation of the antioxidant activity. The analyses were made upon fresh leaves collected from three coastal areas of Tunisia (North (sub-humid), center (higher semi-arid) and South (lower arid)) and using different leaves’ extracts. The results emphasized that Southern ‘Meski’ trees had leaves with more polyphenols, flavonoids, o-diphenols and tannins compared with the Northern ones. From the North to the South, ‘Meski’ leaves showed an increase of carotenoids and a decrease of chlorophyll a and b contents. The highest level of antioxidant compounds of Southern leaves could be contributed to reduce the oxidative stress of the olive tree. The spectrophotometric analysis of the antioxidant capacity of leaves collected from central and Southern areas, based on DPPH and ABTS radical-scavenging activity, showed a higher value of antioxidant activity than the Northern ones, at different extract concentrations. Therefore, the increase of the analyzed bioactive compounds can be considered as a response of the tree to surround aggressions and to oppose the oxidative stress that results from the severity of climatic conditions, characteristic of the Southern area.
Heavy metal uptake and growth characteristics of Amaranthus caudatus L. under five different soils in a controlled environment
Authors: JIMOH Muhali O. , AFOLAYAN Anthony J. , LEWU Francis B.
Published: March 2020

This study investigated the influence of soil types on morphological growth characteristics in Amaranthus caudatus. Seeds of A. caudatus were sown in soils formulated using USDA soil triangle technique and after germination, variabilities in the mean leaf area, shoot height, girth, mean number of branches and leaves per representative stand on different soils were measured. Also, heavy metal uptake characteristics of the plant were examined by comparing the concentrations of trace metals in the soil before and after planting with amount retained in the plant shoot. The results of soil mineral analysis indicated variabilities in the mineral content of the soil before and after planting. While some trace element concentrations got depleted after planting, some appreciated considerably. In addition, variabilities observed in the mean leaf area, shoot height, girth, mean number of branches and leaves per representative plant on different soils suggested the critical role of minerals present in each soil type in plant development. Some essential minerals such as calcium and magnesium were returned to the soil in three-fold of their initial concentrations. This suggested that the plant could serve as a phytoremediator of such minerals, particularly in mineral deficient areas. Also, reduced acidity of the post-harvest soils further showed the plant’s capacity to mop up high acidity in an environment, thus; a good candidate for phytoremediation. For optimal yield in afore-mentioned growth parameters in a regulated environment, loam and silty clayey loam soils are recommended for cultivation of Amaranthus caudatus.
In vitro embryo rescue for the production of hypotetraploids after cross between hypotetraploid and tetraploid grape cultivars
Authors: KIM Si-Hong , KWON Joon-Ho , PARK Young-Sik , HEO Jae-Yun
Published: March 2020

Consumer demand for seedless grape with high quality and large berry has been increasing. Breeding of hypotetraploid grape was suggested as one of promising methods to satisfy it, but low frequency of hypotetraploid occurrence and low seed germination by abortive embryo were indicated as the major problem to hamper the development of hypotetraploid grape. Hence, this study was carried out to evaluate the basic efficiency of in ovulo embryo culture after the cross between hypotetraploid (‘Hanareum’) and tetraploid (‘Honey Black’ and ‘Kyoho’) grape cultivars on the establishment of hypotetraploid grapes. Embryos and plantlets were hardly obtained in ovules cultured at six after the cross pollination (WAP), but ovules inoculated at 10 WAP produced more embryos as well as plantlets regardless of cross combination. Furthermore, we found that embryo formation was not affected by the basal media in ovules cultured at six WAP, but utilization of specific medium can be more beneficial for embryo formation when ovules were cultured at 10 WAP. A total of 17 plants were obtained from ovules cultured at 10 WAP, and above 50% of plants were identified as hypotetraploid grapes. These results indicate that in vitro embryo rescue after cross pollination between hypotetraploid and tetraploid grape can enhance the efficiency for the breeding of hypotetraploid grapes.
Analysis of secondary metabolites and in vitro evaluation of extracts of Carica papaya and Azadirachta indica leaves on selected human pathogens
Authors: FALANA Mansurat B. , NURUDEEN Quadri O.
Published: March 2020

Extraction of the leaves of Carica papaya (family Caricaceae) and Azadirachta indica (family Meliacea) were done using solvents with varying polarities (acetone, hexane and ethylacetate). The crude extracts were screened for phytoconstituents using the preliminary method and high-performance liquid chromatography (HPLC) for separation and quantification of the constituents. Susceptibility of three medically important microorganisms (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Candida alblicans) to the solvent extracts was tested at 100 mg/mL, 50 mg/mL and 25 mg/mL concentrations the disc diffusion technique. Tannins, saponins, alkaloids, steroids, flavonoids and anthraquinone were present in all the solvent extracts of A. indica and C. papaya. Protein was present in all the solvent extracts of A. indica but absent in all the solvent extracts of C. papaya. Terpenoid was only present in hexane extract of A. indica but absent in other solvent extracts of A. indica and C. papaya. Flavonoid was present in all but only absent in ethylacetate extract of A. indica. Glycoside was present in all but absent in hexane extract of A. indica. Coumarin was only present in acetone extracts of both plants and absent in other solvent extracts of the two plants. Extracts of Carica papaya and Azadirachta indica displayed varying inhibitory activities (between 5.00-15.00 mm) against the organisms at all the tested concentrations. Acetone extract of A. indica produced zones of inhibition ranging from 5.00-14.00 mm while acetone extract of C. papaya produces a range of 4.00-10.00 mm. Also, hexane extract of A. indica produced inhibition range of 7.00-10.00 mm whereas hexane extract of C. papaya produces a range of 5.00-15.00 mm. However, ethylacetate extract of A. indica produced inhibition range of 5.00-13.67 mm, while ethylacetate extract of C. papaya produce a range of 5.00-15.00 mm. Different compounds quantified as different peaks by HPLC in the different solvent extracts of Carica papaya are acacic acid, genistein, protodioscin, betulinic acid, phorbolester, creptolepinone, brusatol and alpha ionone while the fractions from the solvent extracts of Azadirachta indica are myricetin, azadirachtol, azadirachtin a, pentadecane, phytol, azadirachnol, quercetin, b caryophyllen, alpha ionone, ascaridole, trams.b.farnes. Results obtained in this work indicated that all the solvent extracts of Carica papaya and Azadirachta indica contained active phytoconstituents and the extracts displayed good potentials at preventing diseases associated with the microorganisms tested in this work.
Effects of irrigation management and seasonal stages on essential oil content and biomass of Origanum vulgare L.
Authors: THANER DOS SANTOS Hugo , ALCARDE SERMARINI Renata , MORENO-PIZANI Maria A. , ALVES MARQUES Patricia A.
Published: March 2020

The responses of oregano plants to water limitation from soil and seasonal phenological cycle are not fully understood yet. The aim of the present research was to help understanding the production of oregano essential oil and biomass facing soil water deficit, which was studied in different seasons. Oregano was subjected to drip irrigation, the water deficit being assessed in the vegetative and pre-flowering stages, as well as whole cycle analysis, through water matric potentials in the soil. The matric potential -60.8 kPa adopted in the irrigation handling during the oregano cultivation interval, led to higher essential oil content and yield. The same potential applied during the oregano pre-flowering stage resulted in the best mean of oregano fresh biomass production. The best dry biomass production was reached by using the matric potential -91.2 kPa in the oregano pre-flowering irrigation management. Water restriction in the soil throughout the entire phenological cycle favored essential oil production, whereas the water restriction during the pre-flowering stage enabled high oregano dry biomass production. The highest values for biomass and essential oil productions were reached for the oregano plants cultivated during spring/summer.
Introduction Pages
Authors: SESTRAS Radu E.
Published: March 2020

Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 1, Volume 12, 2020: The papers published in this issue represent interesting novelties in different topics of life science. Among the exciting researches, we invite readers to find news about: vultures, their population status and some ecological aspects in an Indian stronghold; analysis of secondary metabolites and in vitro evaluation of extracts of Carica papaya and Azadirachta indica leaves on selected human pathogens; the risk mitigation indices associated with some risk mitigation protocols performed on contaminated aqua-cultured catfish (Clarias gariepinus); evaluation of three plant species to control black scurf disease of Irish potato (Solanum tuberosum Linn.); production, purification and characterization of thermostable alpha amylase from Bacillus subtilis Y25 isolated from decaying yam (Dioscorea rotundata) tuber; influence of ammonium and moisture on survival and nifH transcription in the diazotrophic Pseudomonas mendocina S10; two additions to the Asteraceae of Egypt; micromorphology studies of three important medicinal plants of Asclepiadaceae family; phenological attributes of Pyracantha crenulata - a high-value multipurpose shrub of the Himalaya; in vitro callus and shoot regeneration in Enterolobium cyclocarpum (Jacq.) Grised. - a fast timber yielding species.
A EDUCAÇÃO CIÊNCIA, TECNOLOGIA E SOCIEDADE NO CURSO DE LICENCIATURA EM CIÊNCIAS DA UFPR LITORAL
Authors: DOMICIANO TAMARA DIAS , LORENZETTI LEONIR
Published: March 2020

RESUMO: A Educação Ciência, Tecnologia e Sociedade (CTS) corresponde a um Ensino de Ciências socialmente comprometido. Contudo, para que essa abordagem ocorra no ambiente escolar, é preciso discutir, na formação de professores, a educação CTS. Devido a particularidades que apontam esse caminho, o curso de Licenciatura em Ciências da UFPR Litoral tornou-se alvo desta pesquisa que objetiva analisar as abordagens da educação CTS presentes no Projeto Pedagógico do Curso de Licenciatura em Ciências da UFPR Litoral, na percepção e na prática dos docentes formadores. A partir de um estudo de caso, com base no Projeto Pedagógico do Curso, observações e entrevistas, foi possível constatar abordagens da educação CTS crítica, com potencialidade de formar professores críticos, que compreendem as relações sociais da ciência e da tecnologia, e conscientes de seu papel social.
Sintagma identidade-metamorfose-emancipação na trajetória da pessoa com deficiência
Authors: Wagner Valdilene , Garcia Lucas França , Lucena Tiago Franklin Rodrigues , Oliveira Leonardo Pestillo de
Published: March 2020

Resumo Uma em cada sete pessoas no mundo tem alguma deficiência, e para que possam se emancipar é fundamental que sua identidade seja reconhecida. Este estudo qualitativo de caráter descritivo baseou-se no método de análise do relato oral da vida de uma pessoa com deficiência física, acometida por síndrome pós-poliomielite, em cadeira de rodas, entendida aqui como sujeito emblemático. O objetivo foi entender pela narrativa como o ambiente constrói a identidade e produz metamorfoses emancipatórias. Como aparato teórico, utilizou-se o sintagma identidade-metamorfose-emancipação. Os resultados revelaram vários aspectos da vida do indivíduo, que foram discutidos separadamente e estruturados em linha do tempo para facilitar a visualização e análise dos dados. Portanto, apesar de assumir diversos personagens durante a vida, o sujeito emblemático não consegue emancipar-se devido à manutenção de determinadas estruturas reprodutoras de estigmas que dificultam ou até mesmo impossibilitam o reconhecimento de sua identidade. Aprovação CEP-Unicesumar CAAE 79724817.4.0000