bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS MANAJEMEN RISIKO DI CV. LADANG MANAGEMENT MENGGUNAKAN MODEL HOUSE OF RISK (HOR)
Authors: Teguh Oktiarso  , Immanuel Nathaniel Ondang  , Sunday Noya
Published: December 2022

Manajemen risiko digunakan untuk meminimalkan atau menghilangkan efek yang dapat diakaibatkan oleh agen risiko yang akan menyebabkan kerugian bagi proses bisnis yang dilakukan oleh perusahaan. CV. Ladang Management adalah usaha perorangan yang bergerak pada bagian advertising yang banyak memerlukan pertimbangan dalam membuat keputusan dalam menjalankan bisnisnya. CV. Ladang Management perlu melakukan model House of Risk untuk menentukan identifikasi agen risiko dan rencana mitigasi yang tepat untuk mengatasi agen risiko prioritas. Berdasarkan pengolahan data dan analisis hasil didapatkan sebanyak 15 kejadian risiko dengan 15 agen risiko yang mempengaruhi proses bisnis CV. Ladang Management. Kemudian dari 15 agen risiko tersebut didapatkan 7 agen risiko prioritas yang mendapatkan rencana mitigasi sebanyak 11 rencana mitigasi yang memungkinkan untuk dilakukan pada CV. Ladang Management. Hal yang harus dilakukan oleh pihak CV. Ladang Management adalah memilih penjahit prioritas dan dengan jarak yang optimal yang menghasilkan jahitan yang baik serta melakukan investasi dalam bentuk mesin jahit pada setiap tempat penjahit.
Manajemen Pengembangan Kurikulum Madrasah Berbasis Ilmu Sosial Profetik dalam Mewujudkan Madrasah Unggul di MA An Nawawi Berjan Purworejo
Authors: Rokhmawanto Sulis , Marlina Dwi , Arifah Umi
Published: December 2022

This study aims to analyze the management of prophetic social science-based madrasah curriculum development in realizing superior madrasas at MA An Nawawi Berjan Purworejo. This study uses a qualitative case study approach with data collection techniques carried out through a process of observation, interviews, and documentation. Data analysis was carried out by recording data, data reduction, data display, data and drawing conclusions. The results of research in the implementation of prophetic social science-based curriculum management at MA An-Nawawi Berjan Purworejo that in the content of the material integrate general material with religious material as a foundation for transcendence values. In the application of the value of humanism, it has become a culture of pesantren where the interaction of hablun minannas is intertwined because pesantren and madrasah are places for social interaction between students with different backgrounds. The learning method used is the scientific method in the general learning process, while the integrated material uses the sorogan, bandongan, lecture, question and answer methods, practice with the content of the material being taught adjusted.
Penerapan Manajemen Berbasis Madrasah dalam Meningkatkan Mutu Madrasah di MTs Ma’arif Sempor
Authors: Hanifah Hanifah , Fatimah Siti
Published: December 2022

This research examines the application of madrasah-based management in improving the quality of madrasas at MTs Ma'arif Sempor, Kebumen Regency. This research is a type of qualitative research with research subjects at MTs Ma'arif Sempor Kebumen. Methods of data collection using documentation techniques, observation, interviews. The data analysis technique uses the Miles and Huberman model. The results of the study concluded that: 1) madrasa autonomy in improving the quality of madrasas using eight national standards; 2) madrasah participation in improving the quality of madrasah, namely using the efforts of the committee, community and madrasah members; 3) the leadership of the madrasa head is divided into five of them: the head of the madrasa as a motivator, the head of the madrasa as an innovator, the head of the madrasa as an educator, the head of the madrasa as a supervisor, the head of the madrasa as a leader; 4) teamwork carried out by madrasas, namely establishing cooperation with several stakeholders
Kepemimpinan Kepala Madrasah Dalam Pembelajaran Pada Masa Pandemi Covid-19
Authors: Wahid Muchdjabir , Fauziah Muna
Published: December 2022

The purpose of this study was to analyze the leadership of the madrasa head in learning management during the Covid-19 pandemic at MTs An Nawawi 03 Kebumen. This research is a qualitative research. The subject of this research is the head of MTs An Nawawi 03 Kebumen. Data obtained through observation techniques, interviews, and documentation. Data analysis was carried out with the stages of data reduction, presentation, and drawing conclusions. The results of this study are that the head of the madrasa manages learning during the Covid-19 pandemic well. Evidenced by the continuing process of teaching and learning activities. Learning activities are carried out using several applications to liaise between teachers and students at MTs An Nawawi 03 Kebumen.
Praktik On The Job Training (OJT) II Pelatihan Calon Pengawas Madrasah
Authors: Riyadi Surip
Published: December 2022

On The Job Training is one of the best methods for providing high skills or skills to employees because this method is planned, organized and carried out in the workplace and employees are trained on how they carry out their job duties. This article aims to (1) provide an overview of the implementation of each item of activity which is the main task of prospective school/madrasah supervisors along with various supporting and inhibiting factors in the implementation of each item of school/madrasah supervision; and (2) Provide an overview of the condition of the assisted school/madrasah based on the results of an assessment conducted by prospective school/madrasah supervisors. Based on the results and discussion of the practice of On The Job Training (OJT) II, the following conclusions can be drawn: (1) The understanding of prospective Madrasah supervisors on supervision regulations is very important so that prospective supervisors are not mistaken in making policies related to the supervisory program; and (2) To carry out the supervision program, it is necessary to build good synergy between teachers, madrasah heads, supervisors, and related agencies so that the supervision program is maximally successful.
Our First Experience Implementing “Clinical Embryology and Reproductive Medicine” as a Curriculum Course of the Study Program General Medicine at the Faculty of Medicine in Bratislava, Slovakia
Authors: Varga I , Lapides L , Brucknerová I , Gálfiová P , Visnyaiová K , Csöbönyeiová M , Klein M , Žiaran S , Sysák R , Záhumenský J
Published: December 2022

There is no separate course in the medical curriculum summarizing all aspects of human reproduction in most medical school curricula. At the same time, such a course would logically connect knowledge from clinical embryology and assisted reproduction, encompassing the issue of female and male infertility, mechanisms of birth defect formation, their prenatal diagnosis and subsequent specialized neonatal care. The aim of a wide team of university teachers comprising embryologists, gynecologists, neonatologists, endocrinologists, geneticists and others was to create and implement a new course entitled "Clinical Embryology and Reproductive Medicine" into the fourth-year curriculum of the study program General Medicine at the Faculty of Medicine, Comenius University in Bratislava. There has been a great interest in the course, as evidenced by the number of medical students enrolled. The lecture syllabuses have been divided into several thematic areas: 1) Clinical embryology including a laboratory part of assisted reproduction, 2) Cause and treatment options of female and male infertility, 3) A comprehensive view of the issue of birth defects, 4) The issue of preconception education, prenatal and childbirth training, family planning, 5) Reproductive immunology and endocrinology. Despite the complexity of human reproduction being a mainstay of gynecology and obstetrics, it is underemphasized in the medical school curricula worldwide. It is often reflected in shorter hospital / practical trainings during undergraduate studies and lower requirements at the final exam. Therefore, as students almost unanimously valued, this new course is extremely helpful in preparing for the final state exam.
Forming scientific-methodical principles of satellite agroecological monitoring in Ukraine
Authors: Tarariko O. , Ilienko T. , Kuchma T. , Adamchuk- Chala N. , Bilokin O.
Published: December 2022

The article presents the historical aspects of developing remote agroecological monitoring. It is shown that in the process of improving satellite sensors, opening access to foreign satellite data, the possibilities and effectiveness of using the results of remote sensing in scientific and environmental protection activities, in the production of safe agricultural products have expanded. The stages of forming scientific and technical program of satellite agro-ecological monitoring «Agrokosmos», the main fundamentals, tasks and results of this research direction are analyzed. The effectiveness of satellite information for determining the structure of agrolandscapes and land use systems, climate change, its impact on the condition of crops and their moisture supply, productivity of grain crops is shown. Methodical approaches to identifying and mapping manifestations of desertification processes, erosive degradation of agricultural land and associated negative trends are considered. It is noted that modern satellite information is an important tool not only for improving the agroecological monitoring system, but also for developing and implementing measures to achieve a neutral level of soil degradation, prevent the development of desertification processes, and adapt to climate change. It has been proven that the satellite agroecological monitoring system needs improvement in terms of more detailed classification of individual elements of agrolandscapes, as well as improvement of algorithms and image processing methods to expand the possibilities of timely using these data to provide management recommendations and prompt adjustment of agricultural technologies. The main directions of further development of the «Agrokosmos» program are presented. An important issue remains the strengthening of the coordination of research works with the scientific institutions of the National Academy of Sciences, the State Space Agency, the development of cooperation with foreign partners within the framework of international projects. The urgent task of improving the information potential of the use of Earth remote sensing data is the creation of a national network of sub-satellite terrestrial agricultural test sites. The effective use of satellite data in management, production and scientific activities in agriculture requires creating an interdepartmental informative and analytical center «Agrokosmos» within the framework of the National Academy of Sciences and the Ministry of Agricultural Policy and Food.
Agro-ecological risk of pesticides application for protecting apple plantations in the conditions of Pre-Carpathian Province of the Carpathian mountains in Ukraine
Authors: Gunchak M.
Published: December 2022

It was found that the rate of detoxification of pesticides depends on their physicochemical properties and correlates with the polarity of the compounds. According to the magnitude of dipole moments, the studied pesticides are divided into three groups: nonpolar with µ from 0 to 2 Debye (D), low-polar with µ from 2 to 6 Debye and polar with µ more than 6 Debye. Non-polar pesticides are practically insoluble in water and their decay period in the ecosystem is longer than that of low-polar and polar pesticides. Peculiarities, speed and dynamics of pesticide detoxification in the apple orchard ecosystem have been studied. It was found that non-polar pesticides decompose at a rate of 0.07–0.12±0.05 parts per day, and low-polar pesticides — at a rate of 0.15–0.22±0.05 parts per day. On the tenth day after spraying, 0.05 to 1.24 mg/kg of the studied pesticides were detected in apple fruits and from 0.15 to 4.41 mg/kg in apple leaves. The classification of pesticides according to the degree of danger was carried out and it was found that the studied drugs have a degree of danger from 3 to 6. Pesticides with 3 degrees of danger are more dangerous to humans and biota and require more detailed regulation, regulation and control. The seasonal load of pesticides (H) for the intensive chemical system was 29.5 kg/ha, for the advanced system — 10.5 kg/ha and for the system of biological and chemical protection — 0.45 kg/ha. The weighted average hazard (Q) in the intensive chemical protection system was 5.0, for the advanced system — 4.9, and for the biological and chemical protection system — 6.8. It was found that the agroecotoxicological index for all protection systems was less than 1, all protection systems are not very dangerous and do not lead to ecosystem pollution. For the intensive system of chemical protection, this figure ranged from 0.24 to 0.49, for the advanced — from 0.014 to 0.025, and for the system of biological and chemical protection — from 6·10–5 to 8·10–5.
Modern prerequisites for forming social environmental value according to behavioristic approach
Authors: Lazarenko V.
Published: December 2022

Considerable attention is paid to forming a sustainable environmentally friendly culture of ecologically safe food consumption, in particular in the context of the European Green Course on Ukraine’s ability to meet the requirements of the Association Agreement with the European Union in terms of harmonization of EU environmental legislation with domestic and requirements of this Directive. The impact of this course on the culture of consumption of environmentally friendly products and the attitude to the environment in the long run is described. The impact of military aggression by the Russian Federation on the culture of consumption and the attitude of Ukrainian consumers to their own resources in modern conditions is assessed, the existing environmental problems of the agro-sphere and the consequences facing Ukrainian agriculture in the near future are emphasized. The value-hierarchical structure of an individual according to the behavioral approach in ecologically oriented agriculture in accordance with the epistemological principle is substantiated, where the driving element of changes is a specific person at the cognitive-individual level. Emphasis is placed on the institutional support of environmental education and increase its level in the social sphere, which is the main fundamental and institutional tool for ensuring sustainable consumption of environmentally friendly products and caring attitude of members of society to their own resources and the environment as a whole. It is emphasized that the solution to environmental and food security lies in the systematization of rational and irrational behavior of the individual, which should be based not only on the principles of economic efficiency, but also in the formation of national environmental culture and consciousness, based on sustainable development. Ensuring a proper culture of consumption of environmentally friendly products in Ukraine will have a significant impact on the state of environmental and food security in the world.
Applying remote photo shooting technology in ballet photography
Authors: Stepanov Andrey
Published: December 2022

This paper focuses on the topic of remote photo shooting technologies in photography. An attempt was made to analyze various methods and applications for photography during a pandemic and choose the best one. This article discusses the most effective solution from the point of view of my own project named Dance&Nature. Author took into account his experience and results and tell about it. The paper draws a simple and clear conclusion about the best set of functions and the quality of the result in terms of acceptability and convenience for the photographer.
Case report: Sclerosed hemangioma of the liver: A diagnostic challenge
Authors: Poras M. , Katsanos G. , Agrafiotis A. C. , Demetter P. , Pezzullo M. , Lucidi V.
Published: December 2022

Hemangiomas are the most common noncystic benign hepatic tumors and are usually incidentally discovered during routine radiological examinations. The diagnosis of hepatic hemangiomas with a typical presentation is generally easy with plain and cross-sectional imaging; however, it can be complicated when hemangiomas undergo histological changes such as fibrosis. Sclerosed hepatic hemangioma (SHH) is the extreme presentation of this fibrotic process. These atypical lesions can be misdiagnosed as primary hepatic malignancies or metastasis. Their diagnosis is established by histological examination. We report the case of a patient with an SHH, which was misdiagnosed as an intrahepatic cholangiocarcinoma. This article's aim is to draw attention to this infrequent pathology and underline the features of this benign tumor that could suggest its diagnosis prior to surgery to avoid unnecessary hepatic resections.
Evaluation of Fatty Acid Distributions and Triacylglycerol Species in Sow Milk and Commercial Piglet Formulas: A Comparative Study Based on Fat Sources and Lactation Stages
Authors: Ren Cuirong , Jin Jun , Huppertz Thom , Zhang Yanbing , Jin Qingzhe , Wang Xingguo
Published: December 2022

Total fatty acid and sn-2 fatty acid compositions, and triacylglycerol (TAG) species in 130 sow colostrum, 100 sow milk, and 22 piglet formula samples were analyzed in the present study. Significant differences were found in concentrations of medium chain-saturated fatty acids (MC-SFAs) and distributions of palmitic acid (P) and oleic (O)/linoleic (L) acid. The levels of MC-SFAs in sow colostrum and sow milk fats (2.4–3.1%) were significantly lower than those in piglet formulas (7.9–27.2%). Approximately 63% of palmitic acid was located at the sn-2 position in both sow colostrum and milk fats, which was significantly higher than in piglet formula fats (21.1–39.1%). Correspondingly, only 17.8–28.3% of oleic and linoleic acids were at the sn-2 position in sow milk fats, contributing to their typical triacylglycerol structure in sow colostrum and milk, whose palmitic acid connected to the sn-2 position and unsaturated fatty acids located at the sn-1,3 positions. Sow colostrum, milk, and piglet formulas were notably distinguished into three groups based on their fatty acids and TAGs, among which triacylglycerols were the most differentiated index. A total of 51 TAG species (including their isomers) differed significantly between sow colostrum and milk and piglet formulas. OPL and OPO were the most important differentiating TAGs. The large amount of sn-2 esterified palmitic acid plays a key role in improving the absorption of fat and calcium. The results provide suggestions for design of sow milk fat equivalents.
Conservation Management of the Endangered Asiatic Lions in Gujarat, India, Using GPS Satellite Telemetry
Authors: Ram Mohan , Sahu Aradhana , Srivastava Nityanand , Jhala Lahar , Zala Yashpal , Venkataraman Meena
Published: December 2022

Endangered Asiatic lions (Panthera leo persica) are found in the Asiatic Lion Landscape, Gujarat, which includes protected areas and a multi-use land matrix. Therefore, monitoring lions’ space-use and spatio-temporal location is vital for managing various facets of human−lion interaction. Our study demonstrates how this was achieved by tracking lions using GPS radio-collars, triggering prompt action via an efficient communication network across political and forest administrative boundaries. We monitored the movement of 19 individual lions for 436.5 ± 32 days and also derived the mean daily activity from three-axis accelerometer-based activity-sensing feature of a radio-collar. We also monitored geofence breaches. We proposed that immobility and movement are two aspects that generate management action on the ground. While the movement is related to ranging and dispersal, immobility is a situation related to either the animal’s feeding or its health status. From a management standpoint, we discussed the efficacy of the virtual geofence in preventing accidents when lions moved and also presented the advantages of being able to track dispersal through a case study of sub-adult lions. To strengthen our response to lion immobility, we developed a predictive model that specifically highlights an individual lion’s health status and makes the alert response more precise. In conclusion, we critically reviewed the capabilities provided by GPS telemetry and provide protocols that help in the conservation management of lions and that will also have a wider application.
An In Vitro and In Silico Investigation about Monteverdia ilicifolia Activity against Helicobacter pylori
Authors: de Paula Mariana Nascimento , Ribeiro Taísa Dalla Valle Rörig , Isolani Raquel , de Medeiros Araújo Daniela Cristina , Borges Augusto Santos , Philippsen Gisele Strieder , de Cássia Ribeiro Gonçalves Rita , Kitagawa Rodrigo Rezende , Seixas Flavio Augusto Vicente , de Mello João Carlos Palazzo
Published: December 2022

Monteverdia ilicifolia is a Brazilian native plant, traditionally used to treat gastric diseases that are now associated with Helicobacter pylori and are commonly associated with several human diseases. We point out the M. ilicifolia extract as active against H. pylori. The crude extract produced with acetone:water presented the best H. pylori inhibitory activity of all five extracts (MIC 64 µg/mL). The ethyl-acetate fractions from crude extracts produced with ethanol and acetone showed a MIC of 64 µg/mL. Both ethyl-acetate fractions and the crude extract produced with acetone showed an antioxidant capacity of between 14.51 and 19.48 µg/mL in the DPPH assay. In the FRAP assay, two ethyl-acetate fractions (EAF2 and EAF4) presented the antioxidant capacity of 5.40 and 5.15 mM Trolox/g of extract. According to the results obtained from the antioxidant and antibacterial assays, two fractions (EAF2 and nBF5) were analyzed by mass spectrometry and confirmed the presence of monomeric, dimeric, trimeric tannins, and glycosylated flavonoids. Some compounds were tested using bioinformatics to evaluate the best enzyme inhibitors and the molecular interaction between the enzyme and the tested ligands. The presence of these polyphenol compounds could play an important role in antioxidant and inhibitory capacities against H. pylori and can be used to assist in the treatment or prevention of infection by H. pylori.
Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer
Authors: Akhiani Ali A. , Martner Anna
Published: December 2022

Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.
Changing Convection in Central Asia during the Seasonal Transitional Period and Region to Its West before and after 1999: Role of Upper Vertical Thermal Contrast
Authors: Vaid Bakshi Hardeep
Published: December 2022

The objective of this study is to investigate and understand the changes in thermal contrast in the upper troposphere over Central Asia before and after 1999. It was observed that there was a discernible increase/decrease in upper tropospheric temperature (TT) in the 100 hPa/250 hPa over the Central Asian region during PRE99, whereas during POST99, it was found to be the other way around. A clear increase and decrease in the upper TT pattern in 100 hPa and 250 hPa can be attributed to anti-cyclonic and cyclonic circulations in the wind shear, respectively. The subtropical jet has been shown to act as a significant dynamical system generating cyclonic circulation over Central Asia, resulting in dynamical features favorable for enhancing convection during PRE99. This is evinced by the structure of the 200 hPa zonal winds, which serve as a surrogate for a subtropical jet. It can be seen that the westerly winds over the southern part and the easterly winds over the northern part of Central Asia culminate in a significant cyclonic circulation over the region. In summary, PRE99 showed an increase in convection over Central Asia and the regions to its west. The anatomy, using geopotential height, relative humidity, total cloud area (TCA) fraction, longwave fluxes (LWF), and shortwave fluxes (SWF) through the top of the atmosphere, is consistent with the above results. To further support these findings, an updated and thorough causality analysis is performed, and it is noteworthy to mention that the variation of thermal temperature contrast is found to be causally related to LWF and SWF.
LiNi0.8Fe0.1Al0.1O2 as a Cobalt-Free Cathode Material with High Capacity and High Capability for Lithium-Ion Batteries
Authors: Elmaataouy Elhoucine , Chari Abdelwahed , El Bendali Ayoub , Tayoury Marwa , Amine Rachid , Aqil Mohamed , Xu GuiLiang , Liu Tongchao , Alami Jones , Dahbi Mouad
Published: December 2022

Obtaining cathode materials with high capacity and cycle stability is one of the main challenges regarding the success of electric vehicle technologies. However, most of the widely used materials with these properties involve the use of toxic and expensive cobalt as the active material. To overcome this challenge, this work proposes a novel cobalt-free cathode material, synthesized for the first time using a solid-state reaction, whose general formula is LiNi0.8Fe0.1Al0.1O2 (NFA). This class of materials offers high capacity and reduces the battery costs by removing cobalt, without jeopardizing the structural stability and safety of the NFAs. The morphology and the structural properties of the obtained NFA cathode material were characterized using different techniques, e.g., scanning electronic microscopy, X-ray diffraction, X-ray fluorescence, and infrared and Raman spectroscopies. The electrochemical activity and diffusivity of the Li-ion during lithium removal and its insertion into the bulk of the NFA cathode demonstrated high-yield specific capacities of ≈180 mAh g−1 at 0.1C, along with a reasonable rate capability and cycling stability, with a capacity retention of ≈99.6% after 100 charge/discharge cycles at a rate of C/2, and whose operando X-ray diffraction experiments have been used to study the crystallographic transitions during the lithiation–delithiation reaction.
How Is Working Memory Related to Reading Comprehension in Italian Monolingual and Bilingual Children?
Authors: Orsolini Margherita , Federico Francesca , Vecchione Michele , Pinna Giorgia , Capobianco Micaela , Melogno Sergio
Published: December 2022

This study explored how working memory resources contributed to reading comprehension using tasks that focused on maintenance of verbal information in the phonological store, the interaction between the central executive and the phonological store (WMI), and the storage of bound semantic content in the episodic buffer (immediate narrative memory). We analysed how performance in these tasks was related to text decoding (reading speed and accuracy), listening and reading comprehension. The participants were 62 monolingual and 36 bilingual children (mean age nine years, SD = 9 months) enrolled in the same Italian primary school. Bilingual children were born to immigrant parents and had a long history of exposure to Italian as a second language. The regression analyses showed that reading accuracy and listening comprehension were associated with reading comprehension for monolingual and bilingual children. Two working memory components—WMI and immediate narrative memory—exhibited indirect effects on reading comprehension through reading accuracy and listening comprehension, respectively. Such effects occurred only for monolingual children. We discuss the implications of such findings for text reading and comprehension in monolinguals and bilinguals.
Different Tyrosine Kinase Inhibitors Used in Treating EGFR-Mutant Pulmonary Adenocarcinoma with Brain Metastasis and Intracranial Intervention Have No Impact on Clinical Outcomes
Authors: Kuo Chia-Yu , Tsai Ming-Ju , Hung Jen-Yu , Wu Kuan-Li , Tsai Ying-Ming , Tsai Yu-Chen , Chuang Cheng-Hao , Lee Tai-Huang , Chen Huang-Chi , Yang Chih-Jen , Chong Inn-Wen
Published: December 2022

Brain metastasis in patients with non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations is a factor of poor prognosis. We conducted a retrospective study to determine the optimal treatment strategy for EGFR-mutant NSCLC patients with brain metastasis receiving or not receiving intracranial intervention. A total of 186 patients treated with an EGFR TKI were enrolled in the study, and 79 (42%) received intracranial intervention. Patients who received intracranial intervention and those who did not had a similar treatment response rate (RR), progression-free survival (PFS) (median PFS: 11.0 vs. 10.0 months, p = 0.4842), and overall survival (OS) (median OS: 23.0 vs. 23.2 months, p = 0.2484). Patients treated with gefitinib, erlotinib, afatinib, or osimertinib had a similar RR (63%, 76%, 81%, or 100%, respectively, p = 0.1390), but they had significantly different PFS (median PFS: 7.5, 10.0, 14.8 months, or not reached, respectively, p = 0.0081). In addition, OS tended to be different between different EGFR TKI treatments (median OS of 19.2, 23.7, or 33.0 months for gefitinib, erlotinib, or afatinib treatments, respectively, p = 0.0834). Afatinib and osimertinib both demonstrated significantly longer PFS than gefitinib in a Cox regression model. Graded prognostic assessment (GPA) versions 2017 and 2022 stratified patients with different OS; patients with higher GPA index scores had significantly longer OS (p = 0.0368 and 0.0407 for version 2017 and 2022, respectively).
Prostate Cancer in Renal Transplant Recipients: Results from a Large Contemporary Cohort
Authors: Marra Giancarlo , Soria Francesco , Peretti Federica , Oderda Marco , Dariane Charles , Timsit Marc-Olivier , Branchereau Julien , Hedli Oussama , Mesnard Benoit , Tilki Derya , Olsburgh Jonathon , Kulkarni Meghana , Kasivisvanathan Veeru , Lebacle Cedric , Rodriguez-Faba Oscar , Breda Alberto , Soeterik Timo , Gandaglia Giorgio , Todeschini Paola , Biancone Luigi , Gontero Paolo ,   on behalf of the Collaborators
Published: December 2022

Objectives: The aim of this study was to assess the natural history of prostate cancer (PCa) in renal transplant recipients (RTRs) and to clarify the controversy over whether RTRs have a higher risk of PCa and poorer outcomes than non-RTRs, due to factors such as immunosuppression. Patients and Methods: We performed a retrospective multicenter study of RTRs diagnosed with cM0 PCa between 2001 and 2019. Primary outcomes were overall (OS) and cancer-specific survival (CSS). Secondary outcomes included biochemical recurrence and/or progression after active surveillance (AS) and evaluation of variables possibly influencing PCa aggressiveness and outcomes. Management modalities included surgery, radiation, cryotherapy, HIFU, AS, and watchful waiting. Results: We included 166 men from nine institutions. Median age and eGFR at diagnosis were 67 (IQR 60–73) and 45.9 mL/min (IQR 31.5–63.4). ASA score was >2 in 58.4% of cases. Median time from transplant to PCa diagnosis was 117 months (IQR 48–191.5), and median PSA at diagnosis was 6.5 ng/mL (IQR 5.02–10). The biopsy Gleason score was ≥8 in 12.8%; 11.6% and 6.1% patients had suspicion of ≥cT3 > cT2 and cN+ disease. The most frequent management method was radical prostatectomy (65.6%), followed by radiation therapy (16.9%) and AS (10.2%). At a median follow-up of 60.5 months (IQR 31–106) 22.9% of men (n = 38) died, with only n = 4 (2.4%) deaths due to PCa. Local and systemic progression rates were 4.2% and 3.0%. On univariable analysis, no major influence of immunosuppression type was noted, with the exception of a protective effect of antiproliferative agents (HR 0.39, 95% CI 0.16–0.97, p = 0.04) associated with a decreased risk of biochemical recurrence (BCR) or progression after AS. Conclusion: PCa diagnosed in RTRs is mainly of low to intermediate risk and organ-confined at diagnosis, with good cancer control and low PCa death at intermediate follow-up. RTRs have a non-negligible risk of death from causes other than PCa. Aggressive upfront management of the majority of RTRs with PCa may, therefore, be avoided.
Quality of Life Considerations in Endoscopic Endonasal Management of Anterior Cranial Base Tumors
Authors: Saraswathula Anirudh , Porras Jose L. , Mukherjee Debraj , Rowan Nicholas R.
Published: December 2022

Considering quality of life (QOL) is critical when discussing treatment options for patients undergoing endoscopic endonasal skull base surgery (EESBS) for cancers at the base of the skull. Several questionnaires have been developed and validated in the last 20 years to explore QOL in this patient population, including the Anterior Skull Base Questionnaire, Skull Base Inventory, EESBS Questionnaire, and the Sino-Nasal Outcome Test for Neurosurgery. The Sino-Nasal Outcomes Test-22 and Anterior Skull Base Nasal Inventory-12 are other tools that have been used to measure sinonasal QOL in anterior cranial base surgery. In addition to pathology-related perturbations in QOL endoscopic surgical options (transsellar approaches, anterior cranial base surgery, and various reconstructive techniques) all have unique morbidities and QOL implications that should be considered. Finally, we look ahead to new and emerging techniques and tools aimed to help preserve and improve QOL for patients with anterior cranial base malignancies.
Engineering the Tumor Immune Microenvironment through Minimally Invasive Interventions
Authors: Pal Koustav , Sheth Rahul A.
Published: December 2022

The tumor microenvironment (TME) is a unique landscape that poses several physical, biochemical, and immune barriers to anti-cancer therapies. The rapidly evolving field of immuno-engineering provides new opportunities to dismantle the tumor immune microenvironment by efficient tumor destruction. Systemic delivery of such treatments can often have limited local effects, leading to unwanted offsite effects such as systemic toxicity and tumor resistance. Interventional radiologists use contemporary image-guided techniques to locally deliver these therapies to modulate the immunosuppressive TME, further accelerating tumor death and invoking a better anti-tumor response. These involve local therapies such as intratumoral drug delivery, nanorobots, nanoparticles, and implantable microdevices. Physical therapies such as photodynamic therapy, electroporation, hyperthermia, hypothermia, ultrasound therapy, histotripsy, and radiotherapy are also available for local tumor destruction. While the interventional radiologist can only locally manipulate the TME, there are systemic offsite recruitments of the immune response. This is known as the abscopal effect, which leads to more significant anti-tumoral downstream effects. Local delivery of modern immunoengineering methods such as locoregional CAR-T therapy combined with immune checkpoint inhibitors efficaciously modulates the immunosuppressive TME. This review highlights the various advances and technologies available now to change the TME and revolutionize oncology from a minimally invasive viewpoint.
CD301b+ Macrophages as Potential Target to Improve Orthodontic Treatment under Mild Inflammation
Authors: Wang Nan , Zhao Qin , Gong Zijian , Fu Liangliang , Li Jiaojiao , Hu Li
Published: December 2022

Due to improvements of quality of life and the demand for aesthetics, more and more people are choosing orthodontic treatments, resulting in a surge in adult orthodontic patients in recent years. However, a large amount of clinical evidence shows that many orthodontic patients have mild periodontitis in the periodontal tissues, which affects the efficacy of the orthodontic treatment or aggravates the periodontal condition. Therefore, it is important to identify the key factors that affect orthodontic treatments in this inflammatory environment. The aim of this study was to investigate the role of macrophages in orthodontic treatments under inflammatory environments. By analyzing the functional groups of macrophages in the orthodontic rat model of periodontitis, we found that macrophages with high expression levels of CD301b could improve the periodontal microenvironment and improve the efficiency of the orthodontic tooth movement. CD301b+ macrophages transplanted into the model can promote osteogenesis around orthodontic moving teeth, improve bone remodeling during orthodontic treatment, and accelerate orthodontic tooth movement. Considered together, these results suggest that CD301b+ macrophages may play an active role in orthodontic treatments in inflammatory environments and may serve as potential regulatory targets.
Calculation and Lubrication Characteristics of Cylindrical Roller Bearing Oil Film with Consideration of Thermal Effects
Authors: Zhang Mian , Ma Xiqiang , Guo Nan , Xue Yujun , Li Jishun
Published: December 2022

Aiming at the problem of how the thermal characteristics of cylindrical roller bearings affect the lubrication characteristics of bearings under actual working conditions, the influence of parameters such as speed and load on the lubrication characteristics of cylindrical roller bearings under thermal effects is analyzed. The numerical calculation method combining the quasi-static model of cylindrical roller bearing and the thermal elastohydrodynamic lubrication model is adopted. The effects of rotational speed, load and thermal effect on the lubrication performance of the bearing and the lubrication state under certain oil supply conditions were analyzed via numerical model calculation. The oil film thickness was measured via an immersion ultrasonic method to verify the correctness of the model. The results show that the larger the bearing speed, the larger the central film thickness and the minimum film thickness. At the same time, the thermal effect on the film thickness is more obvious; the greater the load, the greater the maximum oil film pressure. The film thickness gradient in the inlet region is greatly reduced, but the thermal effect has no obvious effect on the overall film thickness. In addition, there is a critical value of effective lubrication film thickness for each set of operating parameters. When the actual film thickness is equal to the critical value, the bearing lubrication state is at its best; the numerical simulation results are compared with the experimental values. Under the calculation conditions, the maximum error at the measuring point is within 10%, which meets the error requirements and provides a theoretical basis for revealing the bearing lubrication mechanism.
Zein-Functionalized MCM-41 Silica Nanoparticles with Enzyme-Responsive for Controlled Release in Antibacterial Activity
Authors: Sun Huimin , Lu Yuyang , Sheng Jie , Song Yishan
Published: December 2022

This research provided a novel enzyme-responsive antimicrobial carrier aiming at overcoming the volatile loss of active antibacterial components, by employing mesoporous silica nanoparticles (MCM-41) as the matrix of encapsulation and Zein as the molecular gate. Since Zein could be consumed by bacteria, Zein-functionalized MCM-41 acted as an enzyme-responsive gate and improved the controlled-release capacity. The results showed that the amount of capsaicin released from Zein-functionalized MCM-41 without bacteria was quite low compared with the essential oils liberated with bacteria. This validated that the delivery of capsaicin was hampered by Zein and the existence of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) promoted the release of encapsulated cargo. The release rate of capsaicin in Zein-functionalized MCM-41 climbed with the growth velocity of bacteria. These functions were realized in the form of controlled diffusion of essential oils encapsulated in MCM-41 by electrostatic interaction, and Zein was performed by both covalent bonding interaction and electrostatic interaction. Zein-functionalized MCM-41 was 2.4 times more effective in killing E. coli and 1.2 times more effective in inhibiting S. aureus than an equal amount of free capsaicin, and possessed a long-lasting antibacterial activity. The responsive antimicrobial material might be used as a promising preservative in the food industry for antimicrobial activity enhancement.
Air/Water Heat Pumps in Existing Heating and Hot Water Systems for Better Urban Air Quality and Primary Energy Savings: Scenarios of Two Italian Cities
Authors: Carella Alberta , Del Ferraro Luca , D’Orazio Annunziata
Published: December 2022

In a previous work, a significant contribution to urban air pollution, related to fuel-fired heating systems, was recorded. Thus, the replacement of existing boilers for space heating and domestic hot water (DHW) production systems with high-temperature air/water heat pumps (which can operate with radiators, the most common terminals in the existing building stock), is proposed for the improvement of the urban air quality. Scenarios of substitution within the entire residential building stock of two Italian cities, Milan and Salerno, belonging to different climate zones and with their own thermophysical characteristics, were analyzed. For each of them, the consequences of the replacement intervention on emission reduction, primary energy savings and lower CO2 production were evaluated. The results show that reduction of primary energy consumption, evaluated at design outdoor temperature and for the present generation mix, varied between 34% and 54% in Milan and between 43% and 60% in Salerno, for two values of renewable fraction in electricity generation. The reduction of CO2 production was in the range 30–52% in Milan and 39–58% in Salerno, respectively. The only unfavorable case occurred for Milan for a completely non-renewable electricity generation scenario. The replacement intervention, which implies a significant decrease of emissions of pollutants in urban areas, is unobtrusive to citizens, since the heat pumps (HPs) are coupled with current radiators, without the internal distribution system being modified.
Damage Diagnosis of Pinus yunnanensis Canopies Attacked by Tomicus Using UAV Hyperspectral Images
Authors: Ma Yunqiang , Lu Junjia , Huang Xiao
Published: December 2022

It remains challenging to control Tomicus spp., a pest with fast spreading capability, leading to the death of large numbers of Pinus yunnanensis (Franch.) and posing a severe threat to ecological security in southwest China. Therefore, it is crucial to effectively and accurately monitor the damage degree for Pinus yunnanensis attacked by Tomicus spp. at large geographical scales. Airborne hyperspectral remote sensing is an effective, accurate means to detect forest pests and diseases. In this study, we propose an innovative and precise classification framework to monitor the damage degree of Pinus yunnanensis infected by Tomicus spp. using hyperspectral UAV (unmanned aerial vehicle) imagery with machine learning algorithms. First, we revealed the hyperspectral characteristics of Pinus yunnanensis from a UAV-based hyperspectral platform. We obtained 22 vegetation indices (VIs), 4 principal components, and 16 continuous wavelet transform (CWT) features as the damage degree sensitive features. We classified the damage degree of Pinus yunnanensis canopies infected by Tomicus spp. via three methods, i.e., discriminant analysis (DA), support vector machine (SVM), and backpropagation (BP) neural network. The results showed that the damage degree detected from the BP neural network, combined with 16 CWT features, achieved the best performance (training accuracy: 94.05%; validation accuracy: 94.44%).
Propionic Acid Fermentation—Study of Substrates, Strains, and Antimicrobial Properties
Authors: Antone Unigunde , Ciprovica Inga , Zolovs Maksims , Scerbaka Rita , Liepins Janis
Published: December 2022

Since milk whey is an abundant dairy by-product and a significant threat to the environment, its utilization is of great interest. The study compares valorization of lactose and lactates—the main carbon sources of whey—by fermentation—an environmentally friendly process. Antimicrobials released during fermentation by food-grade bacteria can help increase the microbiological safety of food. Propionic acid—a strong antimicrobial—is obtained mainly by the petrochemical route, yet there is increasing interest in its synthesis in biotechnological pathway. Five strains of propionic acid bacteria (Acidipropionibacterium acidipropionici, Propionibacterium cyclohexanicum, Propionibacterium freudenreichii, Acidipropionibacterium jensenii and Acidipropionibacterium thoenii) were investigated for their ability to produce organic acids and biomass using Na lactate or lactose as carbon sources. Selected fermentates were investigated for their antimicrobial efficacy during in vitro studies with foodborne pathogens: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. Results confirm that the production of acids and biomass is considerably influenced by the added carbon source. The tested fermentates have strong and specific antimicrobial activity against Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. In addition, inhibition of Staphylococcus aureus and Klebsiella pneumonia depends on the activity of produced bacteriocins. The article also discusses the possibility of increasing the antimicrobial activity of fermentates by acidification.
Application of Milk Permeate as an Inducer for the Production of Microbial Recombinant Lipolytic Enzymes
Authors: Greicius Aurimas , Baliutavicius Tautvydas , Lastauskiene Egle , Gudiukaite Renata
Published: December 2022

Recombinantly produced enzymes are applied in many fields, ranging from medicine to food and nutrition, production of detergents, textile, leather, paper, pulp, and plastics. Thus, the cost-effectiveness of recombinant enzyme synthesis is an important issue in biotechnological industry. Isopropyl-β-D-thiogalactoside (IPTG), an analog of lactose, is currently the most widely used chemical agent for the induction of recombinant enzyme synthesis. However, the use of IPTG can lead to production of toxic elements and can introduce physiological stress to cells. Thus, this study aims to find a simpler, cheaper, and safer way to produce recombinant enzymes. In this study, production of several previously designed recombinant lipolytic enzymes (GDEst-95 esterase, GD-95RM lipase, fused GDEst-lip lipolytic enzyme, and putative cutinase Cut+SP from Streptomyces scabiei 87.22) is induced in E. coli BL21 (DE3) using 4 mM milk permeate, a type of waste of the milk manufacturing process possessing >82% lactose. The SDS-PAGE analysis clearly indicates synthesis of all target enzymes during a 2–12 h post-induction timeframe. Further investigation of GDEst-95, GD-95RM, GDEst-lip, and Cut+SP biocatalysts was carried out spectrophotometrically and using zymography method, confirming production of fully active enzymes.