bluuebunny/crossref_metadata_2025 huggingface dataset:
Increased Phase Cone Turnover in 80–250 Hz Bands Occurs in the Epileptogenic Zone During Interictal Periods
Authors: Ramon Ceon , Holmes Mark D.
Published: December 2020

We found that phase cone clustering patterns in EEG ripple bands demonstrate an increased turnover rate in epileptogenic zones compared to adjacent regions. We employed 256 channel EEG data collected in four adult subjects with refractory epilepsy. The analysis was performed in the 80–150 and 150–250 Hz ranges. Ictal onsets were documented with intracranial EEG recordings. Interictal scalp recordings, free of epileptiform patterns, of 240-s duration, were selected for analysis for each subject. The data was filtered, and the instantaneous phase was extracted after the Hilbert transformation. Spatiotemporal contour plots of the unwrapped instantaneous phase with 1.0 ms intervals were constructed using a montage layout of the 256 electrode positions. Stable phase cone patterns were selected based on criteria that the sign of spatial gradient did not change for a minimum of three consecutive time samples and the frame velocity was consistent with known propagation velocities of cortical axons. These plots exhibited increased dynamical formation and dissolution of phase cones in the ictal onset zones, compared to surrounding cortical regions, in all four patients. We believe that these findings represent markers of abnormally increased cortical excitability. They are potential tools that may assist in localizing the epileptogenic zone.
NeuroRA: A Python Toolbox of Representational Analysis From Multi-Modal Neural Data
Authors: Lu Zitong , Ku Yixuan
Published: December 2020

In studies of cognitive neuroscience, multivariate pattern analysis (MVPA) is widely used as it offers richer information than traditional univariate analysis. Representational similarity analysis (RSA), as one method of MVPA, has become an effective decoding method based on neural data by calculating the similarity between different representations in the brain under different conditions. Moreover, RSA is suitable for researchers to compare data from different modalities and even bridge data from different species. However, previous toolboxes have been made to fit specific datasets. Here, we develop NeuroRA, a novel and easy-to-use toolbox for representational analysis. Our toolbox aims at conducting cross-modal data analysis from multi-modal neural data (e.g., EEG, MEG, fNIRS, fMRI, and other sources of neruroelectrophysiological data), behavioral data, and computer-simulated data. Compared with previous software packages, our toolbox is more comprehensive and powerful. Using NeuroRA, users can not only calculate the representational dissimilarity matrix (RDM), which reflects the representational similarity among different task conditions and conduct a representational analysis among different RDMs to achieve a cross-modal comparison. Besides, users can calculate neural pattern similarity (NPS), spatiotemporal pattern similarity (STPS), and inter-subject correlation (ISC) with this toolbox. NeuroRA also provides users with functions performing statistical analysis, storage, and visualization of results. We introduce the structure, modules, features, and algorithms of NeuroRA in this paper, as well as examples applying the toolbox in published datasets.
MiR-128-3p Alleviates Spinal Cord Ischemia/Reperfusion Injury Associated Neuroinflammation and Cellular Apoptosis via SP1 Suppression in Rat
Authors: Wang Dan , Chen Fengshou , Fang Bo , Zhang Zaili , Dong Yan , Tong Xiangyi , Ma Hong
Published: December 2020

Background

Neuroinflammation and cellular apoptosis caused by spinal cord ischemia/reperfusion (I/R) injury result in neurological dysfunction. MicroRNAs (miRs) have crucial functions in spinal cord I/R injury pathogenesis according to previous evidences. Herein, whether miR-128-3p contributes to spinal cord I/R injury by regulating specificity protein 1 (SP1) was assessed.

Methods

A rat model of spinal cord I/R injury was established by occluding the aortic arch for 14 min. Then, miR-128-3p’s interaction with SP1 was detected by dual-luciferase reporter assays. Next, miR-128-3p mimic and inhibitor, as well as adenovirus-delivered shRNA specific for SP1 were injected intrathecally for assessing the effects of miR-128-3p and SP1 on rats with spinal cord I/R injury. SP1, Bax and Bcl-2 expression levels in I/R injured spinal cord tissues were evaluated by Western blotting, while IL-1β, TNF-α, and IL-6 were quantitated by ELISA. Tarlov scores were obtained to detect hind-limb motor function. Evans blue (EB) dye extravasation was utilized to examine blood–spinal cord barrier (BSCB) permeability. Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining was performed for neuronal apoptosis assessment.

Results

MiR-128-3p expression was decreased, while SP1 amounts were increased in rat spinal cord tissue specimens following I/R. SP1 was identified as a miR-128-3p target and downregulated by miR-128-3p. MiR-128-3p overexpression or SP1 silencing alleviated I/R-induced neuroinflammation and cell apoptosis, and improved Tarlov scores, whereas pretreatment with miR-128-3p inhibitor aggravated the above injuries.

Conclusion

Overexpression of miR-128-3p protects neurons from neuroinflammation and apoptosis during spinal cord I/R injury partially by downregulating SP1.
Can the FUT2 Non-secretor Phenotype Associated With Gut Microbiota Increase the Children Susceptibility for Type 1 Diabetes? A Mini Review
Authors: Giampaoli Ottavia , Conta Giorgia , Calvani Riccardo , Miccheli Alfredo
Published: December 2020

The global toll of type 1 diabetes (T1D) has steadily increased over the last decades. It is now widely acknowledged that T1D pathophysiology is more complex than expected. Indeed, a multifaceted interplay between genetic, metabolic, inflammatory and environmental factors exists that leads to heterogeneous clinical manifestations across individuals. Children with non-secretor phenotype and those affected by T1D share low abundance of bifidobacteria, low content of short-chain fatty acids, intestinal phosphatase alkaline and a high incidence of inflammatory bowel diseases. In this context, host-gut microbiota dyad may represent a relevant contributor to T1D development and progression due to its crucial role in shaping host immunity and susceptibility to autoimmune conditions. The FUT2 gene is responsible for the composition and functional properties of glycans in mucosal tissues and bodily secretions, including human milk. FUT2 polymorphisms may profoundly influence gut microbiota composition and host susceptibility to viral infections and chronic inflammatory disease. In this minireview, the possible interplay between mothers' phenotype, host FUT2 genetic background and gut microbiota composition will be discussed in perspective of the T1D onset. The study of FUT2-gut microbiota interaction may add a new piece on the puzzling T1D etiology and unveil novel targets of intervention to contrast T1D development and progression. Dietary interventions, including the intake of α-(1, 2)-fucosyl oligosaccharides in formula milk and the use of specific prebiotics and probiotics, could be hypothesized.
CircRNA_000864 Upregulates B-cell Translocation Gene 2 Expression and Represses Migration and Invasion in Pancreatic Cancer Cells by Binding to miR-361-3p
Authors: Huang Linsheng , Han Junxiang , Yu Huifan , Liu Jialing , Gui Lili , Wu Zhengkun , Zhao Xinxu , Su Shiqi , Fu Gaohang , Li Fei
Published: December 2020

Background

Pancreatic cancer is a fatal disease with a very poor prognosis due to its characteristic insidious symptoms, early metastasis, and chemoresistance. Circular RNAs (circRNAs) are involved in the development of pancreatic cancer.

Aim

Hence, the aim of this study is to elucidate the mechanism of circRNA_000864 in regulating BTG2 expression in pancreatic cancer by binding to miR-361-3p.

Methods

CircRNA_000864, miR-361-3p, and BTG2 expression patterns in the pancreatic cancer tissues were detected by RT-qPCR. Correlation among circRNA_000864, miR-361-3p, and BTG2 was evaluated by RNA-pull down assay, RNA Immunoprecipitation assay, and dual-luciferase reporter gene assay. After ectopic expression and depletion experiments, 5-ethynyl-2′-deoxyuridine assay, Transwell assay, and flow cytometry were employed to assess the cell proliferation, migration and invasion, cell cycle, and apoptosis. Xenotransplantation of nude mice was conducted to detect the effects of circRNA_000864, miR-361-3p, and BTG2 on tumor growth.

Results

CircRNA_000864 and BTG2 were poorly expressed, and miR-361-3p was highly expressed in the pancreatic cancer tissues. CircRNA_000864 bound to miR-361-3p could target BTG2. Cell proliferation, migration, and invasion were inhibited, and the cell cycle arrest and apoptosis were stimulated after overexpression of circRNA_000864 or BTG2 or downregulation of miR-361-3p. Overexpression of circRNA_000864 or downregulation of miR-361-3p also decreased the tumor growth in vivo.

Conclusions

Conjointly, our findings elicited that the overexpression of circRNA_000864 could promote BTG2 expression to inhibit pancreatic cancer development by binding to miR-361-3p, which represents an appealing therapeutic target for the treatment of pancreatic cancer.
Long Non-Coding RNA LINC02747 Promotes the Proliferation of Clear Cell Renal Cell Carcinoma by Inhibiting miR-608 and Activating TFE3
Authors: Ju Xiang , Sun Yangyang , Zhang Feng , Wei Xiaohui , Wang Zhenguo , He Xiaozhou
Published: December 2020

With the rapid development of biotechnology, long noncoding RNAs (lncRNAs) have exhibited good application prospects in the treatment of cancer, and they may become new treatment targets for cancer. This study aimed to explore lncRNAs in clear cell renal cell carcinoma (ccRCC). Differentially expressed lncRNAs in 54 pairs of ccRCC tissues and para-carcinoma tissues were analyzed in The Cancer Genome Atlas (TCGA), and the most significant lncRNAs were selected and verified in ccRCC tissues. We found that lncRNA LINC02747 was highly expressed in ccRCC (P < 0.001) and was closely related to high TNM stage (P = 0.006) and histological grade (P = 0.004) and poor prognosis of patients (P < 0.001). In vivo and in vitro experiments confirmed that LINC02747 could promote the proliferation of ccRCC cells. We also found that LINC02747 regulated the proliferation of RCC cells by adsorbing miR-608. Subsequent mechanistic research showed that miR-608 is downregulated in ccRCC (P < 0.001), and overexpression of miR-608 inbibited the proliferation of RCC cells. Moreover, we found that TFE3 is a direct target gene of miR-608. MiR-608 regulated the proliferation of RCC cells by inhibiting TFE3. In conclusion, LINC02747 upregulates the expression of TFE3 by adsorbing miR-608, ultimately promoting the proliferation of ccRCC cells. The above findings indicate that LINC02747 acts as an oncogene in ccRCC and may be developed as a molecular marker for the diagnosis and prognosis of ccRCC. The LINC02747/miR-608/TFE3 pathway may become a new therapeutic target for ccRCC.
An Integrated Network, RNA Sequencing, and Experiment Pharmacology Approach Reveals the Active Component, Potential Target, and Mechanism of Gelsemium elegans in the Treatment of Colorectal Cancer
Authors: Wang Lin , Xu Hai-li , Liang Jing-wei , Ding Ying-ying , Meng Fan-hao
Published: December 2020

In this study, a combination of network pharmacology, bioinformatics analysis, molecular docking and transcriptomics was used to investigate the active ingredient and potential target ofGelsemium elegansin the treatment of colorectal cancer. Koumine was screened as the active component by targeting PDK1 through network pharmacology and reverse docking. RNA-Seq, enrichment analysis and validation experiment were then further employed to reveal koumine might function in inhibiting Akt/mTOR/HK2 pathway to regulate cell glycolysis and detachment of HK2 from mitochondria and VDAC-1 to activate cell apoptosis bothin vitroandin vivo. In the present study, we provide a systematical approach for the identification of effective ingredient and potential target of herbal medicine. Our results have important implication for the intensive study of koumine as novel anticancer agents for colorectal cancer and could be supportive in its further structural modification.
Hemostatic Balance in Pediatric Acute Liver Failure: Epidemiology of Bleeding and Thrombosis, Physiology, and Current Strategies
Authors: Bulut Yonca , Sapru Anil , Roach Gavin D.
Published: December 2020

Pediatric Acute Liver Failure (PALF) is a rapidly progressive clinical syndrome encountered in the pediatric ICU which may rapidly progress to multi-organ dysfunction, and on occasion to life threatening cerebral edema and hemorrhage. Pediatric Acute Liver Failure is defined as severe acute hepatic dysfunction accompanied by encephalopathy and liver-based coagulopathy defined as prolongation of International Normalized Ratio (INR) >1.5. However, coagulopathy in PALF is complex and warrants a deeper understanding of the hemostatic balance in acute liver failure. Although an INR value of >1.5 is accepted as the evidence of coagulopathy and has historically been viewed as a prognostic factor of PALF, it may not accurately reflect the bleeding risk in PALF since it only measures procoagulant factors. Paradoxically, despite the prolongation of INR, bleeding risk is lower than expected (around 5%). This is due to “rebalanced hemostasis” due to concurrent changes in procoagulant, anticoagulant and fibrinolytic systems. Since the liver is involved in both procoagulant (Factors II, V, IX, XI, and fibrinogen) and anticoagulant (Protein C, Protein S, and antithrombin) protein synthesis, PALF results in “rebalanced hemostasis” or even may shift toward a hypercoagulable state. In addition to rebalanced coagulation there is altered platelet production due to decreased thrombopoietin production by liver, increased von Willebrand factor from low grade endothelial cell activation, and hyperfibrinolysis and dysfibrinogenemia from altered synthetic liver dysfunction. All these alterations contribute to the multifactorial nature of coagulopathy in PALF. Over exuberant use of prophylactic blood products in patients with PALF may contribute to morbidities such as fluid overload, transfusion-associated lung injury, and increased thrombosis risk. It is essential to use caution when using INR values for plasma and factor administration. In this review we will summarize the complexity of coagulation in PALF, explore “rebalanced hemostasis,” and discuss the limitations of current coagulation tests. We will also review strategies to accurately diagnose the coagulopathy of PALF and targeted therapies.
Impact of Opioid Consumption in Patients With Functional Gastrointestinal Disorders
Authors: Melchior Chloé , Desprez Charlotte , Wuestenberghs Fabien , Leroi Anne-Marie , Lemaire Antoine , Goucerol Guillaume
Published: December 2020

Objective: We aimed to determine the burden of opioid consumption in a cohort of patients with functional gastrointestinal disorders.

Methods: All patients diagnosed with functional gastrointestinal disorders and referred to our university hospital were evaluated from 2013 to the beginning of 2019. Irritable bowel syndrome and functional dyspepsia diagnoses were determined according to Rome criteria and severity according to irritable bowel syndrome severity scoring system. Vomiting was quantified using a 5-point Likert scale, and constipation severity was measured using the Knowles-Eccersley-Scott-Symptom questionnaires. Quality of life was quantified by the GastroIntestinal Quality of Life Index. Patients were categorized as being treated on a chronic basis with either tramadol, step II opioids, step III opioids or as being opioid-free.

Results: 2933 consecutive patients were included. In our cohort, 12.5% had only irritable bowel syndrome, 39.3% had only functional dyspepsia, 24.9% had a combination of both, and 23.4% had other functional gastrointestinal disorders. Among them, the consumption of tramadol, step II (tramadol excluded) and step III opioids was 1.8, 1.3 and 0.3 % respectively in 2013 and 4.3, 3.4 and 1.9% in 2018 (p < 0.03). Opioid consumption was associated with increased vomiting (p = 0.0168), constipation (p < 0.0001), symptom severity (p < 0.001), more altered quality of life (p < 0.0001) and higher depression score (p = 0.0045).

Conclusion: In functional gastrointestinal disorders, opioid consumption has increased in the last years and is associated with more GI symptoms (vomiting, constipation and GI severity), higher depression and more altered quality of life.
Signal Transduction Profiling of Angiotensin II Type 1 Receptor With Mutations Associated to Atrial Fibrillation in Humans
Authors: Simões Sarah C. , Balico-Silva André L. , Parreiras-e-Silva Lucas T. , Bitencourt André L. B. , Bouvier Michel , Costa-Neto Claudio M.
Published: December 2020

The AT1 receptor (AT1R) has a major role in the Renin-Angiotensin System, being involved in several physiological events including blood pressure control and electrolyte balance. The AT1R is a member of the G protein coupled receptors (GPCR) family, classically known to couple Gαqand engage β-arrestin recruitment. Both G protein and arrestin signaling pathways are involved in modulation of different downstream kinases. A previous study reported that mutations in the AT1R (A244S and I103T-A244S) were positively correlated with higher risk of atrial fibrillation in men. Based on that report, we aimed to investigate if these mutations, including I103T only, could affect AT1R signal transduction profile, and consequently, implicate in atrial fibrillation outcome. To address that, we engineered an AT1R carrying the above-mentioned mutations, and functionally evaluated different signaling pathways. Phosphokinase profiler array to assess the mutations downstream effects on kinases and kinase substrates phosphorylation levels was used. Our results show that the I103T-A244S mutant receptor presents decreased β-arrestin 2 recruitment, which could lead to a harmful condition of sustained Gαqsignaling. Moreover, the phosphokinase profiler array revealed that the same mutation led to downstream modulation of kinase pathways that are linked to physiological responses such as fibrous tissue formation, apoptosis and cell proliferation.
The Effect of Drought on Transcriptome and Hormonal Profiles in Barley Genotypes With Contrasting Drought Tolerance
Authors: Harb Amal , Simpson Craig , Guo Wenbin , Govindan Ganesan , Kakani Vijaya Gopal , Sunkar Ramanjulu
Published: December 2020

Like many cereal crops, barley is also negatively affected by drought stress. However, due to its simple genome as well as enhanced stress resilient nature compared to rice and wheat, barley has been considered as a model to decipher drought tolerance in cereals. In the present study, transcriptomic and hormonal profiles along with several biochemical features were compared between drought-tolerant (Otis) and drought-sensitive (Baronesse) barley genotypes subjected to drought to identify molecular and biochemical differences between the genotypes. The drought-induced decrease in the leaf relative water content, net photosynthesis, and biomass accumulation was relatively low in Otis compared to Baronesse. The hormonal profiles did not reveal significant differences for majority of the compounds other than the GA20 and the cis-zeatin-o-glucoside (c-ZOG), whose levels were greatly increased in Otis compared to Baronesse under drought. The major differences that emerged from the transcriptome analysis are; (1), the overall number of differentially expressed genes was relatively low in drought-tolerant Otis compared to drought-sensitive Baronesse; (2), a wax biosynthesis gene (CER1), and NAC transcription factors were specifically induced in Otis but not in Baronesse; (3), the degree of upregulation of betaine aldehyde dehydrogenase and a homeobox transcription factor (genes with proven roles in imparting drought tolerance), was greater in Otis compared to Baronesse; (4) the extent of downregulation of gene expression profiles for proteins of the reaction center photosystem II (PSII) (D1 and D2) was low in Otis compared to Baronesse; and, (5), alternative splicing (AS) was also found to differ between the genotypes under drought. Taken together, the overall transcriptional responses were low in drought-tolerant Otis but the genes that could confer drought tolerance were either specifically induced or greatly upregulated in the tolerant genotype and these differences could be important for drought tolerance in barley.
The Extent to Which Obesity and Population Nutrition Are Considered by Institutional Investors Engaged in Responsible Investment in Australia - A Review of Policies and Commitments
Authors: Robinson Ella , Parker Christine , Carey Rachel , Sacks Gary
Published: December 2020

Introduction

Responsible investment (RI), in which environmental, social and governance (ESG) considerations are incorporated into investment decision making, is a potentially powerful tool for increasing corporate accountability and improving corporate practices to address broad societal challenges. Whilst the RI sector is growing, there is limited understanding of the extent to which pressing social issues, such as obesity and unhealthy population diets, are incorporated within RI decision making. This study aimed to investigate the extent to which obesity prevention and population nutrition are considered by Australian institutional investors engaged in responsible investment.

Methods

A desk-based review was conducted of investment approaches of prominent Australian asset managers and superannuation funds identified as engaged in responsible investment. Relevant information on the incorporation of ESG issues related to obesity and population nutrition was extracted for each investor, drawing on websites, published policy documents and annual reports. Strategies were categorized as: (1) negative/exclusionary screening; (2) positive/best-in-class screening; (3) norms-based screening; (4) ESG integration; (5) sustainability-themed investing; (6) impact/community investing; and (7) corporate engagement and shareholder action. These strategies were compared across investors and by themes related to obesity and population nutrition.

Results

Eighteen of the 35 investors indicated that they applied investment strategies that considered issues related to obesity and population nutrition. The most commonly identified strategy was ESG integration (n = 12), followed by sustainability-themed investing (n = 6), and positive screening (n = 4). The ways in which obesity and population nutrition were considered as part of these approaches included relatively high-level general health considerations (n = 12), considerations around the healthiness of food company product portfolios (n = 10), and consideration of specific company nutrition policies and practices (n = 4). The specificity and depth to which RI strategies were disclosed varied.

Conclusion

There is significant potential for investment decisions to contribute to efforts to address key social issues, such as obesity and unhealthy diets. Some institutional investors in Australia have recognized the potential importance of incorporating obesity- and population nutrition-related issues into decision-making processes. However, the extent to which these considerations translate into investment decisions and their impact on companies in the food sector warrant further exploration.
Impact of the COVID-19 Pandemic on Health-Related Quality of Life, Anxiety, and Training Among Young Gastroenterologists in Romania
Authors: Ungureanu Bogdan Silviu , Vladut Catalina , Bende Felix , Sandru Vasile , Tocia Cristina , Turcu-Stiolica Razvan-Aurelian , Groza Andrei , Balan Gheorghe G. , Turcu-Stiolica Adina
Published: December 2020

The novel COVID-19 infection has spread all over the world and is still generating a lot of issues at different levels. There is a lack of control in disease early diagnosis and rapid evolution, which impacts both the medical and the economic system. Young gastroenterologists should adapt to overcome current difficulties and continue their life and general training. This is a multi-center national study, which aims to assess the general perspective of young gastroenterologists (residents and young specialists) from six university centers in Romania regarding their current training and the psychological effect the pandemic has on their life and job. An online survey with 58 items was distributed using Google Forms, and quality of life and anxiety were assessed. The validated instruments 15D (for assessing the health-related quality of life) and endler multidimensional anxiety scales (EMAS—for assessing anxiety) were used. All analyses were performed using SPSS 25. Of the 174 gastroenterologists approached, 96 (response rate of 55%) responded. A majority of the respondents were residents in gastroenterology (64%), and 40.6% were male. The pandemic influenced the number of examined patients as well as young gastroenterologists’ endoscopy training. Health-related quality of life was negatively associated with the level of anxiety generated by the cognitive component of anxiety as a state, the new and ambiguity of the state, and how threatened the respondent felt. The level of anxiety was moderate (median = 51), and no difference was found between the physicians working in a designated hospital or not. General caution should be considered for young gastroenterologists’ training, and continuous observation should be done to ensure better mental health on the current evolution. These findings would need to be verified in larger-sample studies and in different types of specialties.
Explicit (Not Implicit) Attitudes Mediate the Focus of Attention During Sentence Processing
Authors: Horchak Oleksandr V. , Garrido Margarida Vaz
Published: December 2020

Many studies showed that comprehenders monitor changes in protagonists’ emotions and actions. This article reports two experiments that explored how focusing comprehenders’ attention on a particular property of the protagonist dimension (e.g., emotional or action state) affects the accessibility of information about target objects mentioned in the sentence. Furthermore, the present research examined whether participants’ attitudes toward the issues described in the sentence can modulate comprehension processes. To this end, we asked participants to read sentences about environmental issues that focused comprehenders’ attention on different mental and physical attributes of the same entities (protagonists and objects) and then self-report their own thoughts on the topic of environment by responding to the items assessing their environmental awareness. Importantly, we manipulated the task requirements across two experiments by administering a self-report task (Experiment 1), which required the participants to rate the seriousness and the frequency of the problem mentioned in a sentence; and administering a sentence-picture verification paradigm (Experiment 2), which required the participants to merely indicate if the object depicted in the picture (related to a certain environmental problem) was mentioned in the preceding sentence. The results of these experiments suggest that the focus of a sentence on the environmental problem (rather than the protagonist’s emotion and action) enhances the accessibility of information about environmental issues (e.g., plastic garbage); that the comprehender’s level of environmental awareness influences one’s attention during sentence processing; and that comprehender characteristics significantly modulate comprehension processes only when the measures tap into explicit (and not implicit) processes.
Food Folio by Columbia Center for Eating Disorders: A Freely Available Food Image Database
Authors: Lloyd E. Caitlin , Shehzad Zarrar , Schebendach Janet , Bakkour Akram , Xue Alice M. , Assaf Naomi Folasade , Jilani Rayman , Walsh B. Timothy , Steinglass Joanna , Foerde Karin
Published: December 2020

Food images are useful stimuli for the study of cognitive processes as well as eating behavior. To enhance rigor and reproducibility in task-based research, it is advantageous to have stimulus sets that are publicly available and well characterized. Food Folio by Columbia Center for Eating Disorders is a publicly available set of 138 images of Western food items. The set was developed for the study of eating disorders, particularly for use in tasks that capture eating behavior characteristic of these illnesses. It contains foods that are typically eaten, as well as those typically avoided, by individuals with eating disorders. Each image has now been rated across 17 different attributes by a large general United States population sample via Amazon’s Mechanical Turk (n = 1054). Ratings included subjective attributes (e.g., tastiness, healthiness, and favorable texture) as well as estimates of nutrient content (e.g., fat and carbohydrate). Each participant rated a subset of stimulus set food items (46 foods) on all 17 dimensions. Additional description of the image set is provided in terms of physical image information and accurate nutritional information. Correlations between subjective ratings were calculated and an exploratory factor analysis and exploratory cluster analysis completed. Outcomes of the factor analysis suggested foods may be described along three latent factors of healthiness, tastiness, and umami taste; the cluster analysis highlighted five distinct clusters of foods varying on these same dimensions. Descriptive outcomes indicated that the stimulus set includes a range of foods that vary along multiple dimensions and thus is likely to be useful in addressing various research questions surrounding eating behavior and cognition in healthy populations, as well as in those with eating disorders. The provision of comprehensive descriptive information allows for stimulus selection that is optimized for a given research question and promotes strong inference.
Does the Use of Social Media Tools in Classrooms Increase Student Commitment to Corporate Social Responsibility?
Authors: Rodríguez-Gómez Sara , Garde-Sánchez Raquel , Arco-Castro María Lourdes , López-Pérez María Victoria
Published: December 2020

There is an increasing demand for ethical and Corporate Social Responsibility (CSR) practices by companies. This competence has to be introduced in students’ training in business degree programs, and a check must then be done to determine if the students have come to appreciate the importance of CSR commitments. Using the framework of Stakeholders Theory, this work aims to examine students’ perceptions of ethical and CSR practices and commitment to different stakeholders, as well as the factors that lead students to act in a socially responsible way. Furthermore, we hope to identify how the perception of CSR can be improved when Web 2.0 and social media tools that have proven effective in transmitting emotions and values are used in classrooms to teach these ideas. To this end, a survey was carried out in the year 2019 with 1,030 first-year students; it was administered at the beginning of the semester and also at the end of the semester after the training activities had been carried out. The main finding of the research is that students start with the belief that ethics and CSR are developed for reasons of image and legitimacy; however, after receiving training on these topics through tools that take into account emotions and values, they start to value the importance of the company as an agent of social change. The main practical and managerial implication is that methods based on Web 2.0 and social media tools are useful to teach ethics and CSR; the theoretical contribution is that students take into account the welfare of others. This finding contributes to Stakeholder Theory in a higher education context.
Conceptual Analysis: A Social Neuroscience Approach to Interpersonal Interaction in the Context of Disruption and Disorganization of Attachment (NAMDA)
Authors: White Lars O. , Schulz Charlotte C. , Schoett Margerete J. S. , Kungl Melanie T. , Keil Jan , Borelli Jessica L. , Vrtička Pascal
Published: December 2020

Humans are strongly dependent upon social resources for allostasis and emotion regulation. This applies especially to early childhood because humans—as an altricial species—have a prolonged period of dependency on support and input from caregivers who typically act as sources of co-regulation. Accordingly, attachment theory proposes that the history and quality of early interactions with primary caregivers shape children's internal working models of attachment. In turn, these attachment models guide behavior, initially with the set goal of maintaining proximity to caregivers but eventually paving the way to more generalized mental representations of self and others. Mounting evidence in non-clinical populations suggests that these mental representations coincide with differential patterns of neural structure, function, and connectivity in a range of brain regions previously associated with emotional and cognitive capacities. What is currently lacking, however, is an evidence-based account of how early adverse attachment-related experiences and/or the emergence of attachment disorganization impact the developing brain. While work on early childhood adversities offers important insights, we propose that how these events become biologically embedded crucially hinges on the context of the child–caregiver attachment relationships in which the events take place. Our selective review distinguishes between direct social neuroscience research on disorganized attachment and indirect maltreatment-related research, converging on aberrant functioning in neurobiological systems subserving aversion, approach, emotion regulation, and mental state processing in the wake of severe attachment disruption. To account for heterogeneity of findings, we propose two distinct neurobiological phenotypes characterized by hyper- and hypo-arousal primarily deriving from the caregiver serving either as a threatening or as an insufficient source of co-regulation, respectively.
Nursing Students' Perceptions, Knowledge, and Preventive Behaviors Toward COVID-19: A Multi-University Study
Authors: Albaqawi Hamdan Mohammad , Alquwez Nahed , Balay-odao Ejercito , Bajet Junel Bryan , Alabdulaziz Hawa , Alsolami Fatmah , Tumala Regie B. , Alsharari Abdalkarem F. , Tork Hanan M. M. , Felemban Ebaa Marwan , Cruz Jonas Preposi
Published: December 2020

Background:Knowledge, perception, and preventive behavior should be considered in the planning of effective educational interventions for the coronavirus disease of 2019 (COVID-19) pandemic and in increasing awareness about the health risks brought about by this disease. This research aimed to assess knowledge, perceptions, and preventive behavior toward the COVID-19 infection among student nurses.

Methods:The study has quantitative, descriptive, and cross-sectional design. A convenience sample of 1,226 student nurses from seven universities in Saudi Arabia was surveyed from March 22 to April 4, 2020. A four-part online survey on demographic characteristics, perceptions, knowledge, and preventive behavior of Saudi student nurses was carried out.

Results:Nearly all students were aware of the outbreak (99.2%), and most of them received information on COVID-19 primarily from social media (71.0%). Over three-fourths of the students were confident that the government (89.1%) and Ministry of Health (MOH) (86.5%) were doing a good job responding to the COVID-19 outbreak in the country. The overall average score in the knowledge questionnaire was 9.85 (SD = 1.62, range = 0–12), which is equivalent to 82.1%. The majority of the students always performed most of the preventive behavior identified in the survey, except “washing hands with soap and water for at least 20 s after blowing my nose, coughing, or sneezing” (39.2%) and “daily cleaning and disinfecting frequently touched surfaces” (41.6%). Being female, being in the fourth year, and gaining good perceived knowledge were associated with high actual COVID-19 knowledge. University, gender, age, academic level, and perceived COVID-19 knowledge were the associated factors.

Conclusions:The findings of this study have provided baseline information on the current state of Saudi nursing students' perceptions, knowledge, and preventive behavior toward COVID-19 as the crisis is happening. The findings revealed some areas that should be focused on by nursing education, as well as health agencies, to ensure that the students have adequate knowledge and correct preventive behavior.
A Glimpse of the First Eight Months of the COVID-19 Literature on Microsoft Academic Graph: Themes, Citation Contexts, and Uncertainties
Authors: Chen Chaomei
Published: December 2020

As scientists worldwide search for answers to the overwhelmingly unknown behind the deadly pandemic, the literature concerning COVID-19 has been growing exponentially. Keeping abreast of the body of literature at such a rapidly advancing pace poses significant challenges not only to active researchers but also to society as a whole. Although numerous data resources have been made openly available, the analytic and synthetic process that is essential in effectively navigating through the vast amount of information with heightened levels of uncertainty remains a significant bottleneck. We introduce a generic method that facilitates the data collection and sense-making process when dealing with a rapidly growing landscape of a research domain such as COVID-19 at multiple levels of granularity. The method integrates the analysis of structural and temporal patterns in scholarly publications with the delineation of thematic concentrations and the types of uncertainties that may offer additional insights into the complexity of the unknown. We demonstrate the application of the method in a study of the COVID-19 literature.
Separation and Lithological Mapping of PFAS Mixtures in the Vadose Zone at a Contaminated Site
Authors: Bekele Dawit N. , Liu Yanju , Donaghey Mark , Umeh Anthony , Arachchige Chamila S. V. , Chadalavada Sreenivasulu , Naidu Ravi
Published: December 2020

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent organic contaminants of concern to human and environmental health. Several literature reviews and laboratory column experiments have been conducted to determine the transport parameters and to describe the fate of PFAS as they migrate in subsurface environments. However, there are very few case studies focusing on contaminated sites with high-resolution field data. Such studies are crucial for the validation of transport simulation models that have been developed from experimental studies, prior to their broader applications. The key purpose of this research was to evaluate lithological separations of PFAS fractions as they are transported in the vadose zone of a historically (1979) contaminated site where Aqueous Film Forming Foam (AFFF) formulations (3M Lightwater™ and Ansulite™) have been used for fire training exercises. Surface and subsurface soils, and groundwater samples were collected across the site and a total of 29 PFAS compounds were selected as target analytes. The results indicated a distinct profile of PFAS concentration with depth at most of the test bores, exhibiting separation of PFAS as transported in vadose zone soils. Perfluorooctanoic acid (PFOA), Perfluorooctane sulfonic acid (PFOS), and Perfluorohexane sulfonic acid (PFHxS) were the predominant compounds detected in the site samples and they have been found in near-surface soils (<3 m) with concentrations declining with depth. The concentration of the 6:2 fluorotelomer sulfonate showed little change with depth in most of the test bore wells. The percentage concentration of each compound relative to the sum of PFAS, and the ratio of PFHxS/PFOS with depth, suggested transformation processes. Despite the relatively high solubility of PFAS, and that the application of AFFF has been ceased for some years at the site, there were still significant concentrations of PFAS adsorbed to the vadose zone soils that acted as ongoing sources of contamination to groundwater.
Sport for Development and COVID-19: Responding to Change and Participant Needs
Authors: Dixon Marlene A. , Hardie Ashlyn , Warner Stacy M. , Owiro Emmaculate Awour , Orek Dennis
Published: December 2020

As COVID-19 hit in the Spring of 2020, substantial challenges began to emerge for individuals around the world. In this empirical piece we examine the impacts of COVID-19 in the sport for development (SFD) context, as it relates to the individual participant, as well as how those individual needs impact the organization itself. This case study, explores a hybrid SFD organization, Highway of Hope (HOH) in Kenya, and the actions of local leadership in response to emergent participant needs during the onset of the pandemic. Using a case study approach, involving journal responses from program youth participants and local program leadership, along with other field and meeting notes, themes were generated to highlight the most salient challenges and experiences faced by individual participants, as well as the means of addressing those challenges by HOH. Participant journals consisted of both positive and negative thematic findings. Positive experiences included Family Time, Rest, and Practicing Better Hygiene, while negative experiences revolved around Restriction of Activity, and Difficulty at Home. The overall impact on participant lives were expressed in themes such as Socio-emotional, Physical, and Sport-Specific. Further, practical implications for grassroots and hybrid SFD programs during times of unprecedented challenge and notable turning points are highlighted.
Access to Physical Activity and Sport and the Effects of Isolation and Cordon Sanitaire During COVID-19 for People With Disabilities in Scotland and Canada
Authors: Kamyuka Denise , Carlin Liz , McPherson Gayle , Misener Laura
Published: December 2020

People with a disability are more at risk of experiencing inequalities in relation to sporting and physical activity opportunities, COVID-19 and the resulting restrictions stand to exacerbate these inequalities. This research directly contributes toward the World Health Organization, global research roadmap priority to explore “the impact of restrictive public health measures (e.g., quarantine, isolation, cordon sanitaire).” Social loneliness and social isolation have a significant impact on the health and wellbeing of individuals, therefore, it is imperative to gain an understanding of the effects of self-isolation and shielding during Covid-19 for people with disabilities to help those in policy and agency positions address these issues. This research utilized a qualitative approach, to speak with people with a disability, athletes and non-athletes and those in a position of management and policy making. Six online focus groups, with people participating in sport and physical activity, using live captioning, chat functions, and an online written discussion forum; through Project Echo website as part of a wider study on sport and accessibility were utilized. The study also drew on interviews and one of the focus groups was with senior policy makers and regional managers responsible for disability sport in Scotland.
Preparing for an Australian Football League Women's League Season
Authors: Thornton Heidi Rose , Armstrong Cameron R. , Rigby Alex , Minahan Clare L. , Johnston Rich D. , Duthie Grant Malcolm
Published: December 2020

The aims were to investigate the externally measured weekly loads, and the distribution intensity relative to the 1-min maximal mean (MM) intensity of matches. Athletes (n = 28) wore 10 Hz GNSS devices during training and matches. For the descriptive analysis, a range of movement variables were collected, including total distance, high-speed distance, very high-speed distance, acceleration, and acceleration load. Using raw GNSS files, 1-min moving averages were calculated for speed (m·min−1) and acceleration (m·s−2), and were multiplied by time, specifying total distance (m), and by body mass to quantify impulse (kN·s−1). The distribution of distance and impulse accumulated at varied intensities relative to MMs was calculated, with percentages ranging from zero to 110%. Drills were categorized as either; warm-ups, skill drills, games (i.e., small-sided games), conditioning and matches. Linear mixed models determined if the distribution of intensity within each threshold (>50%) varied between drill types and matches, and if the distribution within drill types varied across the season. Effects were described using standardized effect sizes (ES) and 90% confidence limits (CL). Compared to matches, a higher proportion of distance was accumulated at 50% of the MM within warm-ups and conditioning (ES range 0.86–1.14). During matches a higher proportion of distance was accumulated at 60% of MM when compared to warms ups, skill drills and conditioning (0.73–1.87). Similarly, greater proportion of distance was accumulated between 70 and 100% MM in matches compared to skill drills and warm-ups (1.05–3.93). For impulse, matches had a higher proportion between 60 and 80% of the MM compared to conditioning drills (0.91–3.23). There were no other substantial differences in the proportion of impulse between matches and drill types. When comparing phases, during competition there was a higher proportion of distance accumulated at 50% MM than general preparation (1.08). A higher proportion of distance was covered at higher intensities within matches compared to drills. The proportion of impulse was higher between 60 and 80% MM within matches compared to conditioning. Practitioners can therefore ensure athletes are not only exposed to the intensities common within competition, but also the volume accumulated is comparable, which may have positive performance outcomes, but is also extremely important in the return to play process.
“The Old Foods Are the New Foods!”: Erosion and Revitalization of Indigenous Food Systems in Northwestern North America
Authors: Joseph Leigh , Turner Nancy J.
Published: December 2020

The global “nutrition transition” has had an immense impact on Indigenous Peoples of Northwestern North America. From an original diet comprised of mostly local plant and animal foods, including salmon, game, diverse plants, seaweed and other marine foods, many Indigenous people are now eating mostly imported, refined marketed foods that are generally less healthy, and many are at risk of diet-related diseases such as type 2 diabetes. Nevertheless, Indigenous people have always valued their ancestral foods, and over the last few decades there have been many initiatives throughout the region to restore and revitalize these original foods, and to re-learn Indigenous methods of processing and harvesting them. In this paper we describe the original Indigenous food systems in the study region, and the methods used to sustain and promote the ancestral food species and habitats. We then discuss the impacts of colonization, and describe recent and ongoing Resilience and Resurgence in relation to ancestral foods and food practices, including firsthand experiences with renewing food traditions. These initiatives are often connected with language revitalization and cultural resurgence programs. Led by Indigenous communities, they are undertaken with support of academic, government, and other partners. In all, they have resulted in stronger, more vibrant cultures and generally healthier communities.