bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Chromene-linked Bis-indole Derivatives as Selective Tumor-associated Carbonic Anhydrase IX Inhibitors
Authors: Singh Priti , Nerella Sridhar Goud , Swain Baijayantimala , Angeli Andrea , Kausar Samreen , Ullah Qasim , Supuran Claudiu T. , Arifuddin Mohammed
Published: November 2024

Background:

Sulfonamide derivatives are well-reported hCA IX inhibitors; however, they inhibit all
types of hCA without any selectivity, leading to severe adverse effects. Hence, developing a novel nonsulfonamide
class of tumor-associated hCA IX inhibitors through non-classical inhibition may provide greater
selectivity and better pharmacokinetics.

Objective:

The objective of this study was to develop non-sulfonamide derivatives as potential human carbonic
anhydrase (hCA) inhibitors and develop a new series of chromene-linked bis-indole derivatives.

Methods:

We synthesized and characterized the chromene-linked bis-indole derivatives and further evaluated
them against four hCA isoforms, i.e., hCA I, hCA II, hCA IX, and hCA XII, and determined the ADMET parameters
by the In-silico method.

Results:

Most of the compounds showed significantly greater affinity and selectivity towards the tumorassociated
hCA IX over other hCA isoforms within the lower micromolar to submicromolar range. In particular,
the bromo-substituted bis-indole derivative 6t showed an excellent inhibition of hCA IX isoform with an affinity
(Ki) of 2.61 μM. In contrast, the cyano group substituted bis-indole derivative 6s and also displayed a strong
inhibition of hCA IX isoform with an affinity (Ki) of 2.73 μM. Many other potential candidates, including 6g, 6i,
6k, 6m, 6o, 6p, and 6r, showed higher affinity at tumor-associated hCA IX with lower than 10 μM compared to
other hCA isoforms.

Conclusion:

Therefore, the chromene-linked bis-indole derivatives can serve as a novel non-sulfonamide class of
tumor-associated hCA IX inhibitors.
Enhanced Computer-aided Digital Imaging Technique for Predictions in Breast Cancer
Authors: Nagdeote Sushma , Prabhu Sapna , Chaudhari Jayashri
Published: November 2024

Background:

Breast cancer (BRCA) is the most frequently diagnosed cancer in
women, with a rise in occurrences and fatalities. The field of BRCA prediction and diagnosis has
witnessed significant advancements in recent years, particularly emphasizing enhanced
computer-aided digital imaging techniques, and has emerged as a powerful ally in the prediction
of BRCA through histopathology image analysis. A number of approaches have been suggested
in recent years for the categorization of histopathology BRCA images into benign and malignant
as it examines the images at cellular level. The histopathology slides must be manually analysed
which is time consuming and tiresome and is prone to human error. Additionally, different
laboratories occasionally have different interpretation of these images.

Methods:

This paper focuses on implementing a framework for Computer-Aided digital imaging
technique that can serve as a decision support. With recent advancements in computing power
the analysis of BRCA histopathology image samples has become easier. Stain normalization
(SN), segmentation, feature extraction and classification are the steps to categorize the cancer
into benign and malignant. Nuclei segmentation is a crucial step that needs to be taken into
account in order to establish malignancy. These are considered essential for early diagnosis of
BRCA. A unique method proposed for BRCA prediction is put forward. To maximize the
prediction accuracy, the suggested method is integrated with machine learning (ML) techniques
and clinical data is used to evaluate the suggested approach.

Results:

This strategy is adaptable to many cancer types and imaging techniques. The suggested
technique is applied to clinical data and is integrated with logistic regression and K-Nearest
Neighbor resulting in accuracy of 92.10% and 86.89% respectively for BRCA histopathology
images.

Conclusion:

The objective of this work is to validate the proposed model which takes input as
feature pattern for a given label. For the collected clinical samples, the model is able to classify
the input as benign or malignant. The proposed model worked efficiently for different BC
datasets and performed classification task successfully. Integrating mathematical model (MM)
with ML model for interpreting histopathology BRCA is a potential area of research in the field
of digital pathology.
Optimization of Pectin Extraction Process from Albedo of Citrus Lemon (Citrus limon) Using Ultrasonic Method
Authors:   Universitas Padjadjaran, Filianty Fitry , Alifia Rachma Nur ,   Universitas Padjadjaran, Yuliana Tri ,   Universitas Padjadjaran, Yusuf Asep ,   Universitas Padjadjaran, Putri Selly Harnesa ,   Universitas Padjadjaran
Published: November 2024

Abstract Pectin is an industrial raw material that can form gels, thickeners, and emulsifiers widely applied in the food and non-food industries. Extracting pectin with citric acid solvent using ultrasonic waves is considered more effective and efficient. This study aimed to obtain an optimization model for the pectin production process to produce maximum pectin yield and obtain the optimized pectin characteristics. This study used the Response Surface Methodology (RSM) as the optimization method with the Central Composite Design (CCD) experimental design with Design Expert 13 software to determine the treatment combination based on time factors and solvent concentration. The treatment combination obtained was 11. The results showed that the maximum pectin yield value was 34.63% at a 7-minute extraction time using the citric acid solvent concentration of 20% and a validation value accuracy of 99.08%. The optimized pectin characteristics were a water content of 7.66%, ash content of 0.33%, equivalent weight of 183.28 mg, methoxyl content of 7.52%, galacturonic acid content of 67.13%, and degree of esterification of 63.56%. The pectin produced followed the pectin quality standards according to the International Pectin Producers Association (IPPA), except for the equivalent weight. Keywords: extraction, lemon albedo, pectin, ultrasonic Abstrak Pektin merupakan bahan baku industri yang memiliki kemampuan dalam pembentukan gel, zat pengental, dan sebagai zat pengemulsi yang banyak diaplikasikan pada industri pangan dan non-pangan. Proses ekstraksi pektin dengan pelarut asam sitrat menggunakan bantuan gelombang ultrasonik dianggap lebih efektif dan efisien. Tujuan penelitian adalah untuk mendapatkan model optimasi proses produksi pektin hingga menghasilkan rendemen pektin yang maksimum dan mendapatkan karakteristik pektin hasil optimasi. Metode optimasi dalam penelitian ini menggunakan Response Surface Methodology (RSM) dengan dengan rancangan eksperimen Central Composite Design (CCD) menggunakan software Design Expert 13 untuk menentukan kombinasi perlakuan berdasarkan faktor waktu dan konsentrasi pelarut. Kombinasi perlakuan yang diperoleh adalah 11. Hasil penelitian menunjukkan bahwa nilai rendemen pektin maksimum adalah 34,63% pada waktu ekstraksi 7 menit dengan konsentrasi pelarut asam sitrat 20% dengan keakuratan nilai validasi adalah 99,08%. Karakteristik pektin hasil optimasi diperoleh nilai kadar air 7,66%, kadar abu 0,33%, berat ekuivalen 183,28 mg, kadar metoksil 7,52%, kadar asam galakturonat 67,13%, dan derajat esterifikasi 63,56%. Pektin yang dihasilkan sudah sesuai dengan standar mutu pektin menurut International Pectin Producers Association (IPPA) kecuali pada berat ekuivalen. Kata kunci: albedo lemon, ekstraksi, pektin, ultrasonik
A fordítások lexikai kohéziós mintázata – Fordított és autentikus magyar szövegek korpusznyelvészeti vizsgálata
Authors: Seidl-Péch Olívia
Published: November 2024

A fordítási szövegalkotás leírása központi helyet foglal el a fordítástudományi kutatások között. A vizsgálatok eredményei arra utalnak, hogy a fordított szövegek sajátos jellegzetességei nem csupán a nyelvi struktúrák szintjén azonosíthatóak, hanem mélyebb, szemiotikai és pragmatikai szinteken is. A fordítások gyakran tartalmaznak olyan nyelvi elemeket és mintákat, amelyek az adott nyelvre nem, vagy csak másmilyen gyakorisággal és/vagy eloszlással jellemzőek. Az autentikus szövegprodukciótól eltérő fordítási mintázatok jelentős hatással lehetnek a szövegek befogadására és értelmezésére. A lexikai ismétlés szövegszervező funkciójának bemutatott vizsgálata korpusznyelvészeti eszközökkel valósult meg. Az integrált megközelítés nagymintájú szövegvizsgálatot tett lehetővé, s ezzel új perspektívákat nyitott a nyelvtechnológia számára a szövegelemzés területén.A Fordítástudományi értekezések könyvsorozat negyedik köteteként megjelenő A fordítások lexikai kohéziós mintázata című tudományos munka az autentikus szövegprodukciótól eltérő fordítási mintázatok közül a lexikai ismétléskapcsolatokban bekövetkező változásokat vizsgálta. A téma és annak újszerű megközelítése számot tarthat gyakorló fordítók és fordításkutatók érdeklődésére is.
Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study
Authors: Lin Yu-Chun , Yan Huang-Ting , Lin Chih-Hsueh , Chang Hen-Hong
Published: November 2024

Background

Researchers have developed a variety of indices to assess frailty. Recent research indicates that the human voice reflects frailty status. Frailty phenotypes are seldom discussed in the literature on the aging voice.

Objective

This study aims to examine potential phenotypes of frail older adults and determine their correlation with vocal biomarkers.

Methods

Participants aged ≥60 years who visited the geriatric outpatient clinic of a teaching hospital in central Taiwan between 2020 and 2021 were recruited. We identified 4 frailty phenotypes: energy-based frailty, sarcopenia-based frailty, hybrid-based frailty–energy, and hybrid-based frailty–sarcopenia. Participants were asked to pronounce a sustained vowel “/a/” for approximately 1 second. The speech signals were digitized and analyzed. Four voice parameters—the average number of zero crossings (A1), variations in local peaks and valleys (A2), variations in first and second formant frequencies (A3), and spectral energy ratio (A4)—were used for analyzing changes in voice. Logistic regression was used to elucidate the prediction model.

Results

Among 277 older adults, an increase in A1 values was associated with a lower likelihood of energy-based frailty (odds ratio [OR] 0.81, 95% CI 0.68-0.96), whereas an increase in A2 values resulted in a higher likelihood of sarcopenia-based frailty (OR 1.34, 95% CI 1.18-1.52). Respondents with larger A3 and A4 values had a higher likelihood of hybrid-based frailty–sarcopenia (OR 1.03, 95% CI 1.002-1.06) and hybrid-based frailty–energy (OR 1.43, 95% CI 1.02-2.01), respectively.

Conclusions

Vocal biomarkers might be potentially useful in estimating frailty phenotypes. Clinicians can use 2 crucial acoustic parameters, namely A1 and A2, to diagnose a frailty phenotype that is associated with insufficient energy or reduced muscle function. The assessment of A3 and A4 involves a complex frailty phenotype.
Prevalence and influencing factors of myopia and axial length in children and adolescents aged 4 to 18 years in Beijing (Preprint)
Authors: Zhang Hao , Li Shaoli , Cui Mingming , Liu Junting , Chen Fangfang , Gao Yuting , Zong Xinnan , Yang Zhou , Yin Tao
Published: November 2024

BACKGROUND

Childhood myopia has become a growing public health problem worldwide.In recent years, the rate of myopia among Chinese teenagers has increased year by year and has developed into an epidemic trend.At present, most domestic studies have not included the axis of the eye into the research, so the research on the related factors of myopia is not comprehensive enough. The growth of the eye axis will inevitably lead to the stretching and thinning of the sclera, which is more likely to lead to high myopia and pathological myopia, and then further cause sclera, macular and other lesions, resulting in more serious eye diseases.Therefore, it is necessary to add the ocular axis data to the analysis in this study.

OBJECTIVE

This study was performed to explore the prevalence of myopia, axial length changes, and their influencing factors among children and adolescents aged 4 to 18 years in Beijing. The findings are expected to provide a scientific basis for taking effective measures to prevent and control myopia for government decision-making.

METHODS

This cross-sectional survey involved 2595 children from 9 educational institutions (1 kindergarten and 8 schools) in Beijing. The survey included a questionnaire, visual acuity examination, refractive screening, and axial length measurement.

RESULTS

The rate of myopia screening among the tested students was 56.53%, and 50.98% of students had an axial length of >23.5 mm. The eye axis gradually lengthened with age, and the right was longer than the left (P<0.05). Excluding preschool children, the axial length was significantly different between students with and without myopia (P<0.05). The univariate analysis showed significant differences in the myopia rates by age, reading distance, close learning time, lighting environment, and myopia in parents (P<0.05). The multivariate logistic analysis showed that older children and myopia in parents were risk factors for myopia and a longer eye axis, with girls being more likely to develop myopia than boys (odds ratio, 1.35; 95% confidence interval, 1.133–1.597).

CONCLUSIONS

The prevalence of myopia and the proportion of axial length deviation were high in children and adolescents aged 4 to 18 years. Therefore, it is possible to predict the occurrence and development of myopia in children by measuring the axial length and to prevent and control myopia in children and adolescents by decreasing the short-distance reading time and maintaining an adequate reading distance.
Crossing Boundaries: Exploring Transgressability in Arundhati Roy’s Works
Authors: Kumbar Shivayogi , Kumbar Ravikumar S.
Published: November 2024

This study examines Arundhati Roy's The Ministry of Utmost Happiness (2017), a complex narrative exploring India's divided society. Departing from the magical realism of The God of Small Things (1997), Roy's second novel reflects her activism experience, confronting social injustice. Through interconnected stories of Anjum, a transsexual individual, and Tilo, an architect entangled in Kashmir's civil war, Roy portrays postcolonial/ neocolonial India's multifaceted conflicts (religious, political, social, sexual). Amidst hallucinatory violence and moments of harmony, characters traverse seemingly insurmountable borders. This analysis reveals Roy's nuanced exploration of resilience, defiance, and transcendence in everyday life, challenging fixed binaries and borders.
El derecho al mínimo vital tributario en la jurisprudencia de la Suprema Corte de Justicia de la Nación
Authors: Estrada Avilés Mauricio
Published: November 2024

El mínimo vital es un instituto jurídico que encuentra su origen en el derecho a la subsistencia esencial pero que, con posterioridad, es extendido al goce del mayor nivel de bienestar económico y cultural, tanto individual como colectivamente hablando.
El propósito del presente análisis es precisar los matices del mínimo vital en materia impositiva para discernir si lo resuelto por el máximo tribunal, respecto a la previsión normativa contenida en el último párrafo del artículo 151 de la Ley del Impuesto sobre la Renta, que limita las deducciones personales de las personas físicas, cumple o no con el respeto a este postulado, en términos de los derechos humanos predicados por la Constitución de la República.
Integrating Sentiment Analysis and Machine Learning for Improved Film Recommendation Systems
Authors: Patel A. A. , Ubhe V. V. , Vaidya S. G. , Deskmukh K. , Visal V.
Published: November 2024

Abstract: To do so, especially when it comes to digital entertainment platforms, which are evolving rapidly, giving users options for having what they want, and the importance of personalization has simply gone up only. This project focuses on movie recommendations using sentiment analysis, which increases the accuracy of recommendations by adding review sentiments based on movie ratings and reviews. This project presents a movie recommendation system that leverages collaborative filtering and sentiment analysis to deliver more accurate suggestions to movie enthusiasts, specifically targeting "Cinemaniacs" and "Film Junkies.” The primary components of our approach include collaborative filtering, such as taking movie preferences from the user and performing natural language processing (NLP) techniques for sentiment analysis of user-generated reviews and ratings. By integrating user preferences, such as selected genres and viewing habits, with sentiment-driven insights from movie reviews, the system extends beyond traditional numeric ratings to capture nuanced satisfaction and dissatisfaction. The platform also includes genre-specific recommendations and predictive models that forecast upcoming movie releases based on individual tastes, trends, and pre-release sentiments. This innovative combination provides users with highly customized movie and web series suggestions, keeping them updated on new releases, while offering trailer predictions to preview potential interests. Through this multi-layered approach, the project aims to deepen viewer engagement by closely aligning content recommendations with emotional responses and genre preferences
Direito penal econômico na sociedade de risco: uma análise crítica da legislação brasileira à luz da Escola de Frankfurt
Authors: Fernandes Alessandro
Published: November 2024

Este artigo examina o direito penal econômico brasileiro no contexto da sociedade de risco e à luz das teorias da Escola de Frankfurt. Analisa-se como a globalização e a interdependência econômica aumentam a complexidade dos crimes econômicos e como os conceitos críticos da Escola de Frankfurt, como racionalidade instrumental, alienação e dominação, podem ser aplicados para uma compreensão mais profunda desses crimes. O estudo inclui uma revisão bibliográfica, análise crítica e estudos de caso, com o objetivo de explorar as estruturas de poder que influenciam a regulação e a prática do direito penal econômico. Além disso, discute-se as perspectivas futuras e os desafios enfrentados pela legislação penal econômica em um mundo globalizado e interconectado.
The Influence of Library Building Features on Indoor Daylight Quality of Reading Spaces Under Overcast Sky Conditions
Authors: Christiana Okwuosa Chiamaka , Martha Basil Amaka-Anolue , Offia Ibem Eziyi , Emeka Okwuosa Ogechi , Kingsley Anih Ejike
Published: November 2024

Building design features contribute to the performance of indoor daylight quality. Reading spaces in library buildings require effective daylighting for good learning processes and energy savings. This study investigated the indoor daylight quality of the six reading spaces labelled Esut-Hall A, Esut-Hall B, Esut-Hall C, Esut-Hall D, Esut-Hall E, and Esut-Hall F. It determined the influence of individual building design features on daylight quality. The study adopted case study research, combined with an HS1010 light metre experiment. The first result identified twenty-five building design features that influenced the daylight quality. The second result indicated that the illuminance values of Esut Hall A, Esut-Hall B, Esut-Hall D, Esut-Hall E, and Esut Hall F are within the recommended range of 300 lux and 500 lux. Only Esut-Hall C is below the range. The identified design features showed that some of the windows in Esut-Hall C were ineffective due to some internal wall obstructions. Therefore, it was recommended that the effective windows' area be increased, and top-light windows be introduced.
Evaluación del tratamiento alcalino con cal viva (CaO) para la reducción de microorganismos en lodos residuales generados en la PTAR vía Puerto Mosquito, Aguachica, Cesar
Authors: Sanchez Alvarez Nayibe Tatiana , Vargas Blanco Roymar , Herrera Pablo Alberto , Hernandez Martinez Ingris Yohana , Saldaña Escorcia Rossember
Published: November 2024

Contextualización: La aplicación de cal viva como tratamiento alcalino ha sido considerada como una técnica efectiva para la desinfección de lodos residuales. Objetivo: En este estudio, se llevó a cabo una evaluación del tratamiento alcalino con cal viva (CaO) para reducción de microorganismos en los lodos residuales procedentes de la PTAR vía Puerto Mosquito en Aguachica, cesar. Metodología: El proceso implica la adición de cal viva al lodo residual, lo que eleva el pH del medio y crea un ambiente hostil para la supervivencia de microorganismos patógenos y bacterias. Este aumento del pH también facilita la precipitación de compuestos orgánicos y metales pesados presentes en los lodos, lo que contribuye a su estabilización. Resultados y conclusiones: Los resultados de la evaluación proporcionaron información sobre la eficiencia del tratamiento alcalino con cal viva en la reducción de microorganismos patógenos y la mejora de la calidad general de los lodos residuales con la concentración de 45%.
Evaluación de la productividad del cultivo de arveja (Pisum sativum l.) bajo sistemasde siembra tradicional y tutorado en Mombita municipio de Aquitania(Boyacá).
Authors: Alarcon Alvarez Edelmira , Camacho Torres Yenny Maritza , Alarcón Urrutia Marionel
Published: November 2024

Contextualización: el estudio se enfoca en el área de la agricultura y la producción alimentaria, centrándose especialmente en el cultivo de arvejas (Pisum sativum L.) en el municipio de Aquitania. Se analiza la posibilidad de introducir esta actividad agrícola como una opción viable y sostenible en una zona que, a lo largo de su historia, ha confiado en prácticas agrícolas tradicionales, como el cultivo de cebolla larga y la cría de ganado. En esa medida, el estudio promueve el desarrollo agrícola sostenible, la seguridad alimentaria y la resiliencia económica en la región de Aquitania y busca ofrecer lecciones valiosas para otras comunidades agrícolas.
Vacío de conocimiento: el sistema de cultivo de arveja desarrollado en el área rural del municipio de Aquitania Boyacá mantiene unas características de producción que pueden resultar deficientes, en comparación con otros métodos de siembra que generarían mayor productividad mediante el fortalecimiento de prácticas agrícolas, sistemas de siembra y manejo del sistema productivo en general.
Propósito: el estudio tiene como objetivo principal evaluar la productividad del cultivo de arveja (Pisum sativum L.) en el municipio de Aquitania, bajo dos sistemas de siembra: sistema de siembra tradicional y sistema de tutorado. Así mismo, fue necesario aplicar técnicas de manejo limpio comunes en la zona y fundamentadas en prácticas agrícolas sostenibles, en comparación con un manejo químico del cultivo donde se propició el uso de fertilizantes, herbicidas, insecticidas y fungicidas comunes en el área de influencia del estudio.
Metodología: la metodología empleada en el estudio se basa en un diseño experimental completamente aleatorizado (DCA), con doce unidades experimentales correspondientes a cuatro tratamientos y tres repeticiones, donde se evaluaron parámetros de productividad como: número de días a germinación, número de días a floración, número de días a cuajado y número de días a cosecha, número de vainas por planta y número de granos por vainas. El estudio incluyó el desarrollo ANOVAS y pruebas de comparación DUNCAN desarrolladas mediante programa R Core Team (2020)
Resultados y conclusiones: como resultados de la investigación se encontró que en los tratamientos 3 y 4, que desarrollaron el sistema de siembra bajo tutorado, se obtuvieron mejores resultados en términos de productividad con respecto al sistema de siembra de forma tradicional.
The role of judicial review in the settlement of state contracts disputes
Authors: Aboelazm Karem Sayed
Published: November 2024

This paper aims to study the recent developments in appealing public procurement contracts (Alhamidah, 2007) by examining the expansion of the administrative judiciary in Egypt in accepting appeals filed against contracts concluded by the state to invalidate contracts tainted by the waste of public money. This paper relied on the analytical approach to analyze several details of the subject under study based on the legal and constitutional frameworks regulating state contracts. In addition, it will examine the judicial rulings issued by the Egyptian State Council. The study reached the significant expansion adopted by the Egyptian State Council in monitoring state contracts, which resulted in the issuance of Law No. 32 of 2014, limiting the right to appeal state contracts to the benefit of the two parties to the contract only.
Wireless charging in mobile phone management system project report
Authors: Acharya Kamal
Published: November 2024

Mobile Phones are part of our life. It is the fastest and the easiest medium of communication. Battery life of mobile phone is always been a problem for manufacturers. People are complaining about their mobile’s battery life, that they don’t have long battery life and they have to charge their phone several times. In this paper a new idea is shown to charge your mobile phone anywhere you want without connecting its charger. This is done using microwaves. Microwaves are the radio waves which provide communication between two mobile phones. The microwave is sent with the message by the transmitter using antenna at the frequency of 2.45GHz. Here we are using Microwaves as the source of energy to charge the phone. We have to add a sensor, a rectenna circuit and a filer in our mobile phone to do the job. By adding these things we can charge our phone using microwave when we talk. So, as we talk more we can charge more!!
National Climate Finance Vehicles: Best Practice Insights from International Case Studies
Authors:   Asian Development Bank Consultant, Schur Michael , Reynolds Aisha ,   Asian Development Bank Consultant
Published: November 2024

This working paper—developed under ADB’s NDC Advance technical assistance platform—sets out the important role that national climate finance vehicles can play in stimulating investment in low-carbon and climate-resilient development. It presents a model design framework and readiness criteria for clarifying the key factors supporting effective operation and achieving prioritized climate outcomes and sustainable development. The paper presents three case studies of national financing vehicles from Australia, Indonesia, and Thailand, identifying success factors and lessons learned. The paper concludes with key recommendations for developing member countries to inform the approach to designing and operationalizing a climate finance vehicle.
Testing readiness of adoption of blockchain technology in tracking the authenticity of organic coffee
Authors: Nudin Septian , Suvajdzic Marko , Lukovac Petar , Barac Dusan , Radenkovic Bozidar
Published: November 2024

This study aims to analyze the readiness for adopting blockchain technology
in tracking the authenticity of organic coffee to provide added value to
consumers and producers of coffee considering technological advances in the
Supply Chain. This study combines the Unified Theory of Acceptance and Use
of Technology (UTAUT) and the Technology Acceptance Model (TAM). An online
questionnaire with eligible respondents is used to collect data which is
then processed using Smart PLS 4.0 software. The data analysis method used
is quantitative. The findings indicate that every explanatory variable has a
positive impact on the dependent variable, suggesting that consumer adoption
of blockchain technology depends on simplicity, advantage, and positive
attitude toward technology use.
Revolutionising the document workflow using blockchain in banking sector
Authors: Domazet Ervin , Merdzan Gunter , Cvetkoska Violeta , Mechkaroska Daniela , Serdaroglu Serdar , Sucubasi Bilal
Published: November 2024

Blockchain is a distributed ledger technology that can revolutionise the
banking sector by increasing transparency, reducing costs, and enhancing
security. However, the success of any banking service lies in the efficiency
of serving it, which depends on the smoothness of internal documents and
process flows. This paper proposes a novel method that uses blockchain
infrastructure to address the efficiency, security, and privacy of workflow
processes in the banking sector. Our approach combines Alfresco DMS and CMIS
with the orchestration tool Camunda for workflow management and secures them
with a notary using the Factom Blockchain. This method provides a secure,
efficient, and reliable way for banks to process transactions, store
documents, and manage their processes. It will enable banks to process
transactions faster, reduce costs, minimise the risk of fraud, increase
customer satisfaction, and fully consider blockchain technology's
advantages.
AI and blockchain framework for healthcare applications
Authors: Ramachandran Muthu
Published: November 2024

Artificial Intelligence (AI) has impacted global economy, workforce
productivity, smart health, smart cities, smart transport, and much more to
come. Large Language Models (LLM) such as ChatGPT and Google?s Gemini, have
been widely adopted in various applications. Blockchain Technology stands as
a towering disruptor in today's tech landscape, offering assurances of
enhanced security and scalability for various applications. Within the realm
of healthcare, its adoption has surged, spanning from streamlined
recordkeeping to bolstered clinical trials, fortified medical supply chains,
and vigilant patient monitoring. These applications harness the intrinsic
attributes of blockchain to elevate standards of safety, privacy, and
security within the healthcare sector. The combined power of AI and
blockchain has the potential to revolutionize healthcare delivery, ensuring
improved security, transparency, and efficiency. Nevertheless, Porru et al.
[1] have highlighted deficiencies in the processes, tools, and techniques
within this domain. Hence, this paper aims to furnish a structured framework
that ensures both security and sustainability in the development of
healthcare blockchain applications. This paper also provides an overview of
societal impact on both technologies. This article has evolved best practice
guidelines and a systematic development framework for AI-Blockchain
integration, known as AI-BlockchainOps. This research has also developed a
reference architecture, exemplifying the modeling of an Electronic Health
Record (EHR) using BPMN and simulation. Within this Electronic Health Record
(EHR) scenario encompassing 100 user requests, the simulation absorbed
97.09% of cloud resources, with 76.33% allocated to knowledge discovery, and
a utilization rate of 93.20% for blockchain scientists, alongside various
other contributing factors.
Do Public Financial Statements Influence Private Equity and Venture Capital Financing?
Authors: Baik Brian K. , Berfeld Natalie , Verdi Rodrigo S.
Published: November 2024

We study whether the availability of public audited financial statements influences the probability of private firms receiving private firm equity financing. Using a setting in the EU with plausibly exogenous variability in the extent to which private firms issue public financial reports, we find that private firms subject to public reporting requirements have a higher probability of obtaining private equity (PE) financing. In addition, we show that the increase in PE financing occurs in industries in which PE funds have prior experience. Last, we show that our findings also extend to other forms of private firm financing such as private firm acquisitions and venture capital. Our evidence highlights the importance of public financial statements in the decision-making of PE investors, an important and understudied segment of the private firm financing market.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: M41; M2; G24; G34.
Renal Epithelioid Angiomyolipoma: Diagnostic and Therapeutic Difficulty!
Authors: I* Ziani
Published: November 2024

Renal epithelioid angiomyolipomas (AMLeR) are rare tumors and account for 8% of angiomyolipomas (AML) operated ; We illustrate an observation of the diangotic and therapeutic difficulties of these types of tumors which remains rare, and whose management is not yet well defined both radiologically and urologically
PRINCÍPIOS SOBRE A FORMAÇÃO HUMANA INTEGRAL A PARTIR DAS PERSPECTIVAS DE ESTUDIOSOS BRASILEIROS
Authors: Ribeiro Roberta Daiane , Marques Welisson , Elias Adriano , Lima Geraldo Gonçalves de
Published: November 2024

O artigo apresenta os princípios da formação humana integral a partir das perspectivas de estudiosos brasileiros, especificamente Paulo Freire e Dante Moura, e como foram influenciados pelos escritos de Karl Marx, Friedrich Engels e Antonio Gramsci. Discute inicialmente os fundamentos históricos e conceituais da educação profissional no Brasil, destacando a evolução das políticas públicas e as transformações no sistema educacional desde a chegada dos portugueses até a criação da Rede Federal de Educação Profissional, Científica e Tecnológica em 2008. Em seguida, examina a gênese do pensamento omnilateral e a concepção de uma educação que busca o desenvolvimento completo dos sujeitos em todas as suas dimensões, através dos escritos de Karl Marx. Paulo Freire, com suas ideias sobre a educação libertadora e a práxis como instrumento de transformação, e Dante Moura, através da sua defesa da formação omnilateral no contexto do ensino médio integrado, são apresentados como referências essenciais para o entendimento relativo a uma educação crítica e emancipatória. Ambos os autores enfatizam a necessidade de superar a dualidade entre a cultura geral e a técnica, promovendo uma formação que capacite os estudantes a compreenderem e transformarem a sua realidade social. A análise revela os desafios e as oportunidades relacionadas à implementação de uma educação integral em um contexto socioeconômico dominado pelos interesses do capital, destacando a importância de posturas educacionais inclusivas e transformadoras.
O PROTAGONISMO JUVENIL NO CONTEXTO DOS ITINERÁRIOS FORMATIVOS NO NOVO ENSINO MÉDIO: UM OLHAR A PARTIR DAS LENTES DA Therapeutic jurisprudence
Authors: Bando Janaina Rossarolla , Fensterseifer Daniel Pulcherio
Published: November 2024

Este artigo tem por objetivo analisar o protagonismo juvenil no contexto dos itinerários formativos no novo ensino médio (NEM), lançando um olhar a partir das lentes da Therapeutic Jurisprudence. O NEM, regulamentado pela Lei nº 13.415/2017, propôs itinerários formativos que buscam uma nova organização curricular, objetivando dar aos estudantes maior autonomia sobre seu percurso educacional. Ocorre que essa autonomia não é exercida em sua amplitude, pois as limitações geradas pela infraestrutura precária das escolas e pela oferta restrita de itinerários, especialmente em regiões mais pobres do pais. Nesse sentido, propõem-se uma revisão bibliográfica, abordando o novo ensino médio e os itinerários formativos, o protagonismo juvenil no contexto educacional: desafios e perspectivas, e o uso da Therapeutic Jurisprudence enquanto abordagem que valoriza o impacto emocional e social das leis. Ao final se pretende demonstrar que a aplicação da Therapeutic Jurisprudence poderia orientar a formulação de políticas públicas que promovesse, de fato, o bem-estar psicológico e emocional dos estudantes impactos pela reforma do ensino médio.
Efficiency of high speed spur gears with an isotropic superfinishing
Authors: Vorgerd Jaacob , Steinrötter Mathis , Thomas Alexander , Oehler Manuel
Published: November 2024

Gear friction is decisive for the efficiency and power density of cylindrical gears. One method to realise the highest possible efficiency is to carry out a isotropic superfinishing. In this paper, a measuring method for evaluating the gear power losses in the regime of high pitch line velocity is presented. Using this measuring method, efficiency analyses of gears with conventional profile grinding and of variants with additional isotropic superfinishing were carried out. The experimental investigations showed a significant potential in gear friction and thus efficiency due to isotropic superfinishing. The potential was confirmed independent of the gear geometry and over the entire range of pitch line velocities investigated.
Rotary shaft seals at high temperatures
Authors: Kröger Matthias , Gerschler Jim , Nepp Ringo , Berndt Christian
Published: November 2024

In many applications, dynamic seals are used at high temperatures which can lead to many problems like damage or ageing of elastomer and lubricant or in formation of oil carbon. A recently built seal test rig enables very high temperatures up to above 250 °C with grease lubrication. Experiments show the influence of high temperatures on function and friction of seals.
BERBAGI PRAKTIK BAIK DALAM BUKTI KARYA LUARAN IN HOUSE TRAINING SEBAGAI MANIFESTASI TAHUN PRAEDICARE TIM SEKOLAH YAYASAN SANTO DOMINIKUS
Authors: Winarti Eny , Hadiyanti Agnes Herlina Dwi
Published: November 2024

One of the works of the Saint Dominic Sister is education. As Indonesian education is shifting in the paradigm, the foundation feels the urgency to equip the education team with the ability to contribute to the Indonesian education trend without losing sight of its vision and mission. One of the Indonesian education trends for teachers is the use of Platform Indonesian Mengajar (PMM - Indonesian Teaching Platform) in which the teachers are expected to take part in developing their portfolio through the platform. By the foundation, this platform is deemed to be in line with the praedicare year I (2024-2025) in which the foundation focuses on making a public declaration. In the effort to announce good practices, preliminary data indicated that few of the school team, who are expected to be role models for other teachers, have actively contributed to PMM. A deeper analysis revealed that the foundation needed to facilitate those teachers to be familiar with the application. To deal with this challenge, a one-day workshop on how to upload the portfolio and what content to be uploaded on the PMM was conducted. The results of the workshop were that all school team in YSD schools were successfully upload their portfolio.
Cooperative learning as a methodological, inspiration in the implementation of a science club
Authors:   University States of Rio Grande do Sul, Brazil, Caroline Ragiuk de Oliveira Daysi
Published: November 2024

The purpose of this study is to introduce a Science Club to develop activities related to the socio-environmental area in a state school in the city of Guaíba, in the state of Rio Grande do Sul / Brazil. These activities cover the reoccupation of the school’s physical spaces, with the aim of making it more sustainable, and the formation of more critical and autonomous students, actively involved in the construction of their knowledge and learning. To achieve this goal, the Science Club was chosen as the means of conducting this research. The methodology for developing the Club’s activities will incorporate elements of Cooperative Learning, since it is believed that this approach can be a significant alternative for addressing current educational challenges, promoting the renewal of teaching and the teacher-student relationship in the classroom. Although the structure of the Science Club is distinct from a traditional classroom, the dissemination and emphasis on the benefits of Cooperative Learning are seen as potential catalysts for new research in the classroom. The research was conducted during Science Club meetings, using Cooperative Learning as a methodology, with a focus on socio-environmental issues pertinent to sustainability. The results indicate that the participants experienced contentment, academic improvements, attitudinal changes and intellectual development after joining and participating in the Science Club activities. However, issues such as participant turnover over the course of the meetings were identified as points that merit review in future research. Thus, despite these challenges, it is believed that the research was able to provide relevant reflections on the subject, potentially stimulating new studies in the area. Finally, as an educational development, a MOOC course is proposed to help train new coordinators and disseminate Science Clubs throughout the country.
At every poit a tale – ethnomathematics in basic education
Authors:   University States of Rio Grande do Sul, Brazil, Karine Silva
Published: November 2024

The result of this project is a descriptive account of the experience developed around Ethnomathematics with the enculturation of the practice of crochet and the integration of the management movement with computational thinking. This report is developed with objectivity and theoretical contributions focused on a general understanding of the keywords; Ethnomathematics, Computational Thinking, Abstraction, Decomposition, Generalization, Algorithm and Crochet. Taking account of these literacies by embracing a transdisciplinary methodology. With the movement to carry out a project that makes a positive and relevant contribution to my area of expertise. Focusing on the search for considerations and reflections that will bring about biopsychological maturation in the student to develop the subject act, leading them towards the formation of a cognizant subject with their thinking, learning and doing. On their lived experiences with the interactions established in the contexts of observations, perceptions, and constructions. Finally, the aim is to report non-biased observations, valuing ethics and critical thinking.
The New European Bauhaus: Beautiful-Sustainable-Together in STARHAUS
Authors:   PhD Student, Doctoral School of Administration
and Public Policies, Faculty of Political, Administrative
and Communication Sciences,
Babeș-Bolyai University, Cluj-Napoca, Romania, BRATU Petruț , KUMAR SRIVASTAVA Akhilesh ,   Senior Scientist, Department of Process Technology,
SINTEF Industry, SINTEF AS, Norway, BUTEAN Alex ,   Associate professor, Department of Computer Science
and Electrical Engineering, Faculty of Engineering,
Lucian Blaga University of Sibiu, Romania
Director, Wiz Research, Romania, VACCARELLA Letizia ,   Research fellow, Department of Social,
Political and Cognitive Sciences,
University of Siena, Italy
Published: November 2024

The article ‘The New European Bauhaus: Beautiful-Sustainable-Together in STARHAUS’ aims to explore the principles of the New European Bauhaus (NEB) policy and analyze how these principles are implemented across various European projects, with a specific focus on the STARHAUS project. The New European Bauhaus is an interdisciplinary initiative launched by the European Commission to foster a sustainable and inclusive future by combining aesthetics, sustainability, and inclusiveness. It seeks to create spaces, products, and services that are environmentally friendly, inclusive, and accessible while enhancing quality of life.
Beyond Transparency Statements: Explaining the Impact of Efficiency
and Auditing on the Disclosure of Public Information
Authors:   Associate Professor, Department of Accounting and Finance, Faculty of Business and Economic Sciences,
University of Granada, Granada, Spain, GARRIDO-RODRÍGUEZ Juan-Carlos , PLATA-DÍAZ Ana María ,   Associate Professor, Department of Accounting and Finance, Faculty of Business and Economic Sciences,
University of Granada, Granada, Spain, LÓPEZ-HERNÁNDEZ Antonio M. ,   Professor, Department of Accounting and Finance,
Faculty of Business and Economic Sciences,
University of Granada, Granada, Spain, POLO GARRIDO Fernando ,   Associate Professor, Research Center
of Enterprises Management (CEGEA),
Polytechnic University of Valencia, Valencia, Spain
Published: November 2024

Transparency has become a key element for public entities as a mechanism of reliability and accountability. In addition, the continuous auditing of these entities, as well as the efficient provision of public services, are important elements that can have an impact on a greater degree of transparency. In this paper, the aim is to measure how these factors influence the level of municipal transparency through an analysis of a sample of 143 Spanish municipalities with more than 50,000 inhabitants using the generalized model of moments. The results show that an efficient and highly audited municipality offers a higher level of public information and influences other political and socioeconomic factors.
Fiscal Illusion and Democratic Maturity: Exploring the Roles of Information,
Trust, and Participation in Citizens’ Perception ff Taxes and Spending
Authors:   Associate professor, Department of Public Administration, Dongguk University, Seoul, Republic of Korea, OH Youngmin
Published: November 2024

The concept of fiscal illusion is a paradox in public finance; that is, people believe that it is possible to expand government services despite decreased revenues. Evidence suggests that fiscal illusion relates to democratic maturity, considering the lack of transparency, trust, and participation in developing countries. Accordingly, an important research question arises: What factors remedy such misperceptions of fiscal situations? This study explores these factors through a survey experiment. The empirical evidence indicates that citizens’ fiscal illusion decreases when transparency in the fiscal process is ensured through information, trust, and participation. This research contributes to the field of public administration by identifying the factors that reduce fiscal illusion in public finance management and providing important policy implications, namely, that developing countries should make more efforts to reduce citizens’ illusion regarding public spending for sustainable growth by transparently disclosing financial information and ensuring trust in government and civic participation.
Conocimiento y políticas públicas en la Provincia de Buenos Aires
Authors: Córdoba María Gabriela
Published: November 2024

Este artículo se enmarca en los primeros avances de un proyecto de investigación universitario que tiene por objetivo indagar la vinculación entre la producción del conocimiento especializado y la toma de decisiones en el diseño de las políticas públicas referidas al turismo, desde el año 2019 hasta 2023, en la Provincia de Buenos Aires, Argentina.
En esta publicación presentamos brevemente los antecedentes que contextualizan la investigación, focalizándonos en las discusiones teóricas entre diferentes perspectivas y autores sobre la temática indagada.
El estado del arte sobre turismo y sector público evidencia escasas contribuciones académicas sobre la relación entre el conocimiento científico y la formulación de políticas públicas en la región, especialmente en contextos de cambios de las dinámicas políticas nacionales y provinciales, aunque advertimos que es un campo de estudio en desarrollo.
El recorrido teórico realizado revela que en la vinculación entre académicos y funcionarios públicos hay limitaciones y obstáculos, pero también articulaciones y encuentros entre ambas esferas para mejorar la calidad y efectividad de las políticas turísticas de la provincia de Buenos Aires. A partir de las reflexiones y hallazgos expuestos, concluimos que se requiere transformar la visión tradicionalista de transferencia de conocimientos por la de traducción, esto implica que el diseño de políticas públicas se adapte al contexto provincial específico para asegurar su relevancia y aplicabilidad.