bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical properties of local upland rice kupang east nusa tenggara, indonesia
Authors: Hanas Dicky Frengky , Tnunay Ite Morina Y , Welsiliana Welsiliana , Makin Florian Mayesti Prima R , Pardosi Lukas , Wiguna I Gede Arya , Tae Lidwina Felisima
Published: January 2023

Local upland rice (Oryza sativa L.) is a type of cereal crop that has the potential for dry land areas. Farmers in Kupang plant upland rice/local rice that has been consumed and used for generations and is considered by the surrounding community as part of their ancestral heritage. The materials used in this research were local upland rice varieties as a result of exploration. The varieties of six local upland rice of Kupang studied in this research had different rice characters in terms of its weight, volume, density and yield.'Aen Molo' has the highest weight per grain and per 1000 grains, namely 0.024 g and 24.95 g, also the highest volume of 1000 grains of rice is 30 ml, while 'Aen Lekes' has the lowest weight per grain and per 1000 grains, namely 0.020 g and 19.66 g and also the lowest volume of 1000 grains, namely 23 ml. The Iodine test results showed that the local rice of Kupang was classified in the regular or non-glutinous rice group. Meanwhile, Alkali test results show that the six samples of local upland rice have a high gelatinization temperature which indicates that local upland rice in Kupang Regency has high amylose content.
A synthetic agent to simulate decisional behaviour of designers working with an active recommender framework system
Authors: Horváth Imre , Tepjit Sirasak
Published: January 2023

Application-specific reasoning mechanisms (ASRMs) development is a rapidly growing domain of systems engineering. A demonstrative implementation of an active recommender system (ARS) was realized to support designing ASRMs and to circumvent procedural obstacles by providing context-sensitive recommendations. The specific problem for the research presented in this paper was the development of a synthetic validation agent (SVA) to simulate the decisional behaviour of designers and to generate data about the usefulness of the recommendations. The fact of the matter is that the need for the SVA was raised by the pandemic, which prevented involving groups of human designers in the recommendation testing process. The reported research had three practical goals: (i) development of the logical fundamentals for the SVA, (ii) computational implementation of the SVA, and (iii) application of the SVA in data generation for the evaluation of usefulness of recommendation. The SVA is based on a probabilistic decisional model that quantifies decisional options according to the assumed decisional tendencies. The three key concepts underlying the SVA are (i) decisional logic, (ii) decisional knowledge, and (iii) decisional probability. These together enable generation of reliable data about the decisional behaviours of human designers concerning the obtained recommendations. The completed tests proved the above assumption.
The Relationship between Erectile Dysfunction, Sexual Self Efficacy and the Dark Triad
Authors: Samantha Banbury  , Giovanni Moneta  , Chris Chandler  , Paul Hutchison
Published: January 2023

Erectile dysfunction (ED) is the lack, or loss of ability to achieve or maintain an erection and is a commonly reported sexual dysfunction in healthcare. Whilst research has centred on the dark triad, personality, and sexuality; associations between dark triad traits, and sexual dysfunction appear scarce. This study aimed to establish whether there was a relationship between the dark triad traits, sexual self-efficacy (SSE) and ED. Sixty-four participants including 45 men with ED and 19 men without ED, aged between 18-60 years contributed to an online cross-sectional survey consisting of questionnaires measuring ED, the dark triad traits, SSE and demographic information. Results suggested a moderate to high positive correlation with narcissism and psychopathy traits on ED (aggravating effect) and a negative moderate to high correlation with Machiavellianism and SSE (protective effect) on ED. Both Machiavellianism, specifically subscale reputation and SSE were predictors of ED. This suggests that higher levels of SSE and Machiavellianism (reputation) were associated with lower levels of ED and narcissism and psychopathy were associated with higher levels of ED. However, until further research is conducted on a larger and diverse cohort, which examines the causal pathways SSE and the dark triad might have on ED, this remains inconclusive. Nevertheless, this area warrants further exploration, with a view to developing suitable assessment and intervention stratagem in psychosexual services to support ED.
Perfil epidemiológico de los casos de cáncer registrados en un estado de la región norte
Authors: Teixeira Isabelly Montenegro , Lucena Larissa Sena de , Giampietro Zhandra Gramigna , Silva Rúbenns Tavares , Ávila Gabriel Pereira , Dias Claudio Alberto Gellis de Mattos , Dendasck Carla Viana , Oliveira Euzébio de , Fecury Amanda Alves
Published: January 2023

El cáncer engloba un grupo de patologías crónicas con causas multifactoriales y altos niveles de mortalidad en Brasil y en el mundo. Además, constituyen enfermedades con un gran impacto en la morbimortalidad de los pacientes y una elevada carga para el sistema sanitario. Así, la investigación busca delinear el perfil epidemiológico del cáncer en el estado de Amapá desde enero de 2018 hasta marzo de 2021. Para ello se utilizó un estudio descriptivo, retrospectivo, de corte transversal basado en datos públicos secundarios del “Panel Oncologia”, obtenido del Departamento de Informática del Sistema Único de Salud (DATASUS). Se analizaron un total de 610 casos, de los cuales el 52,8% fueron pacientes del sexo masculino, con énfasis en el grupo etario de 65-69 años. Comparando los tipos de cáncer, los más reportados fueron de mama (21,9%), próstata (18,5%) y estómago (12,9%). En cuanto al establecimiento, el Hospital das Clínicas Doutor Alberto Lima (HCAL) fue el servicio de salud que más diagnosticó casos de lesiones malignas en el estado (90,3%) y la unidad CRIO/CE fue el local que recibió el mayor número de pacientes tratados fuera del hogar (46,15%). Se concluye que el cáncer tiene una prevalencia relevante en la población estudiada en la Amazonía y el conocimiento del cuadro epidemiológico permitirá una mejor planificación y estrategias de control de la enfermedad y la priorización de acciones de promoción y prevención de la salud.
Implementasi Hybrid Learning PAI di UPT MPK Unsri Indralaya
Authors: Gafur Abdul , Nurhasan Nurhasan , Switri Endang , Apriyanti Apriyanti
Published: January 2023

After the Covid-19 pandemic, hybrid learning is the right formulation in PAI learning. The aim is to find out how the implementation of PAI learning in the Personal Development Course Technical Implementation Unit (UPT MPK) Sriwijaya University after the Covid-19 pandemic using the Hybrid model and to find out the obstacles in its implementation. The method used is descriptive qualitative research method. The results showed that this activity was quite good although there were still many things that needed to be improved because there were still many obstacles, especially the lack of existing equipment. The level of technological readiness from this research is expected to answer the challenges of educators at Sriwijaya University in particular and in general in the world of other education.
Effect of Operating Parameters on Agricultural Biomass Mixture Pyrolysis Process in a Batch Reactor
Authors: Miljkovic Biljana
Published: January 2023

Many phenomena affect devolatilization of biomass particles, including mass and heat transfer, chemical reactions and physical transformation. Mathematical models that are capable to describe pyrolysis phenomena can greatly assist the large-scale development and optimization of pyrolysis processes, but to be implemented into large-scale simulation the models need to be simplified at a certain degree. In the present study, an existing mathematical model is used to describe the pyrolysis of a single particle of biomass. It couples the heat transfer equations with the chemical kinetics equations. The common Euler explicit method is used for solving the heat transfer equation and the two-step pyrolysis kinetics equations. The model equation is solved for a sphere particle with a radius of 0.001 m and temperature ranging from 300 to 923 K. An original numerical model for the pyrolysis of agricultural biomass mixture is proposed and relevant equations solved using original program realized in MATLAB. Simplified particle model was validated with the experimental data in a non-isothermal pyrolysis reactor. The sample was heated in the temperature range of 300–923 K at average heating rates of 21, 30 and 54 K/min. The model results showed reasonable agreement with experiments. The difference (between the experimental and model results) is slightly more prominent with decreasing heating rate (21 and 30 K/min), but model results are in much better agreement with the experimental date for higher heating rate (54 K/min). It is demonstrated that a constitutive equation can be used to express devolatilization rate for higher heating rates.
19. Yüzyıl Dünya Ekonomisinde Osmanlı Devleti Uluslararası Ticaret Politikaları
Authors: ALTINKAYA Zelha
Published: January 2023

Osmanlı Devleti’nin uluslararası ticaret yollarının merkezinde, kurulmuş, hızla topraklarını genişletmiş; bu süreçte dönemin güçlü devletleri ile uluslararası ticaret ilişkilerine önem vermişlerdir. Geçmişte, çok sayıda araştırmada ele alınmış olmasına rağmen, Osmanlı’ da uygulanan dış ticaret politikaları bugüne kadar elde edilmiş veriler ışığında yeniden derlenmiş ve değerlendirilmiştir. Bu politikalar ve sonuçları, dönemin dünyanın ekonomisinde önde gelen ülkelerin uyguladıkları dış ticaret politikaları ile karşılaştırmalı olarak analiz edilmiştir. Osmanlı ekonomisinin sahip olduğu üstünlükler ve kısıtlamalar ortaya konmuştur. Araştırma, temel olarak, tarihsel açıdan gümrük tarifelerinin karşılaştırılmasına ile ilgili literatür taramasına ve vaka çalışmasına dayanmaktadır.
Edukasi Kesehatan Reproduksi Remaja Di SMP Negeri 137 Jakarta Reproductive Health Education for Students SMP N 137 Jakarta Universitas YARSI
Authors: Andri Damayanti Ndaru , Purnamasari Endah , Ferlianti Rika , Djohan Risdawati , Juniarti Juniarti , Harliansyah Harliansyah
Published: January 2023

Pendidikan kesehatan reproduksi dan informasi tentang isu seksualitas kepada remaja tidak lagi dianggapsebagai suatu hal yang tabu. Masyarakat menyadari pentingnya pendidikan kesehatan seksual menjadi langkah awal memberikan akses informasi yang akurat bagi remaja. Informasi dasar mengenai kesehatanreproduksi, keterampilan bernegosiasi tentang hubungan seksual, dan akses untuk mendapatkan pelayanankesehatan reproduksi yang terjangkau menjadi kebutuhan penting bagi remaja. Fakta menunjukkan banyakremaja yang sudah aktif secara seksual baik secara resmi maupun illegal tanpa dibekali pengetahuan yangmemadai dapat berisiko meningkatkan jumlah penderita penyakit menular seksual dan kegiatan aborsi padaremaja. Kegiatan ini bertujuan meningkatkan pengetahuan remaja tentang pentingnya menghindariperilaku seksual berisiko dan memberikan pengamalan agama dalam kehidupan sehari-harisehingga remaja siap menjalani kehidupan reproduksi yang sehat. Metode yang dilakukan padakegiatan ini adalah penyuluhan tentang kesehatan reproduksi remaja didasarkan pada pemberianpengetahuan kesehatan dan agama kepada remaja menggunakan media power point dan kesempatan tanyajawab. Jumlah peserta edukasi sebanyak 44 orang. Hasil kegiatan menunjukkan 82% peserta.menunjukkanpeningkatan pengetahuan kesehatan reproduksi pada siswa-siswa SMP N 137 Jakarta
SOSIALISASI PEDOMAN GIZI SEIMBANG 2014 BAGI GURU SD N 05 JOHAR BARU
Authors: Umniyati Helwiah
Published: January 2023

Pedoman Gizi Seimbang telah dikenalkan dan disosialisasikan kepada masyarakat lebih dari 15 tahun lalu akan tetapi masih banyak masyarakat di Indonesia yang tidak mengetahui Pedoman Gizi Seimbang. Sehingga perubahan perilaku gizi masyarakat ke arah perilaku gizi seimbang masih jauh dari harapan. Konsumsi pangan belum seimbang baik kuantitas maupun kualitasnya, dan perilaku hidup bersih dan sehat belum memadai. Indonesia menghadapi masalah gizi ganda. Berdasarkan hasil Riskesdas 2013 menunjukkan bahwa “stunting” pada Balita dan prevalensi Penyakit Tidak Menular (PTM) pada dewasa makin meningkat. Upaya perubahan perilaku gizi masyarakat ke arah perilaku gizi seimbang yang merupakan faktor penting dalam pencegahan timbulnya masalah gizi dan mempertahankan status gizi yang baik.

Sebagian besar PTM terkait-gizi di atas berasosiasi dengan kelebihan berat badan dan kegemukan yang disebabkan oleh kelebihan gizi. Berdasarkan data Riskesdas 2007, 2010, 2013 dan 2018 memperlihatkan kecenderungan peningkatan prevalensi obesitas pada semua kelompok umur. Obesitas pada anak balita terjadi peningkatan dari 12,2% pada tahun 2007 menjadi 14% di tahun 2010), setelah itu mengalami penurunan pada tahun 2013 (11,9%)  dan naik lagi menjadi 13,6% pada tahun 2018. Oleh karena itulah, kita berkewajiban untuk menerapkan dan mensosialisasikan pentingnya pedoman gizi seimbang sejak dari anak-anak. Anakyang obese mempunyai risiko yang besar untuk obes ketika dewasa. Kelebihan gizi ini timbul akibat kelebihan asupan makanan dan minuman kaya energi, kaya lemak jenuh, gula dan garam tambahan, namun kekurangan asupan pangan bergizi seperti sayuran, buah­ buahan dan serealia utuh, serta kurang melakukan aktivitas fisik.

Selain masalah kegemukan, hasil riskesdas menunjukkan bahwa Indonesia masih memiliki masalah kekurangan gizi. Kecenderungan prevalensi kurus (wasting) anak balita 13,6% (2007), 13,3% (2010), turun menjadi 12,1% (2013) dan  10,2% pada tahun 2018. Sedangkan kecenderungan prevalensi anak balita pendek (stunting) sebesar 36,8% (2007), 35,6% (2010), 37,2% (2013) dan menjadi 30,2% (2018). Prevalensi gizi kurang (underweight) berturut-turut 18,4% , 17,9%, 19,6%, 17,7% .

Melalui kegiatan pengabdian masyarakat ini, kami meningkatkan pengetahuan masyarakat, khususnya pengetahuan guru-guru SD N Johar Baru akan pentingnya penerapan gizi seimbang, agar mendapatan kesehatan yang optimal. Setelah pelatihan gizi seimbang pada guru didapatkan peningkatan pengetahuan sebanyak 41%. Diharapkan setelah meningkatnya pengetahuan gizi seimbang pada masyarakat maka perilaku gizi masyarakat akan berubah.
Edukasi dengan Permainan Edukatif “Kartu Pintar YARSI HIV-AIDS Care” di SMA 27 Jakarta
Authors: Yasmin Intan Farida , Djannatun Titiek , Widiyanti Dian
Published: January 2023

Kasus baru HIV di kalangan remaja terus meningkat setiap tahunnya, namun tingkat pengetahuan mereka tentang HIV-AIDS masih rendah. DKI Jakarta merupakan provinsi dengan jumlah kasus HIV-AIDS tertinggi. Tujuan dari penelitian ini adalah untuk meningkatkan pengetahuan komprehensif HIV-AIDS pada siswa dengan Kartu Pintar HIV-AIDS YARSI Care. Peserta penelitian sebanyak 70 siswa SMA 27 Jakarta dinilai pengetahuan dan sikapnya terhadap HIV-AIDS sebelum dan sesudah diberikan permainan edukasi. Kartu Pintar HIV-AIDS YARSI Care dimainkan dalam kelompok kecil (7 siswa) yang dipandu oleh mentor. Hasil penelitian menunjukkan adanya peningkatan pengetahuan HIV-AIDS setelah permainan edukasi dan perubahan sikap yang positif terhadap HIV-AIDS. Berdasarkan hasil tersebut, Kartu Pintar HIV-AIDS YARSI Care terbukti efektif dalam meningkatkan pengetahuan dan mengubah sikap positif tentang HIV-AIDS.
Pencegahan Masalah Kesehatan Mental dan Kesehatan Reproduksi Remaja melalui Peran Peer Konselor di 8 SLTA Jakarta Pusat
Authors: Trisiswati Maya , Ranakusuma Octaviani Indrasari , Utami Sri Puji , Nabilah Manda , Nurulhuda Parawita , Hasanah Fitriani Nur , Nurintishar Raina
Published: January 2023

SNPHAR 2018 (Survey Nasional Pengalaman Hidup Anak dan Remaja) Kementerian PPA menyatakan 3 dari 4 pelaku kekerasan pada remaja adalah teman sebayanya. Data Riskesdas 2018 menunjukkan 6% penduduk DKI berusia15-24 tahun depresi dan 10% mengalami stres dan kecemasan. Survei WHO menemukan kehidupan remaja lekat dengan stresor yang kemudian memicu masalah emosional dan kejiwaan. Masa remaja merupakan masa transisi perubahan fisik, kognitif, sosial-emosional, tanggung jawab dan tuntutan sosial yang semakin besar. Mereka mulai menghabiskan waktu bersama teman, mengembangkan otonomitas, konflik dengan orang tua, mulai tertarik dengan seksualitas dan terlibat dalam perilaku seksual. Remaja membutuhkan konseling dengan sebaya melalui PIK-R yang dapat berjejaring PPKS Universitas YARSI. Tujuan dari penelitian ini adalah untuk menjalankan fungsi PIK-R di setiap sekolah mitra, meningkatkan pengetahuan dan keterampilan Siswa SLTA dalam memahami dan mengenali gejala masalah kejiwaan pada remaja, mewujudkan sistem rujukan antara PIK-R dan Guru BK sebagai klinik satelit dan PPKS Universitas YARSI untuk meningkatkan jejaring layanan informasi, konseling dan pendampingan bagi siswa-siswa SLTA Jakarta Pusat. Metode yang digunakan adalah pelatihan tatap muka Peer Konselor siswa secara tatap muka dan pendampingan sekolah. Hasil menunjukkan Pelatihan Peer Konselor dianggap berhasil meningkatkan pengetahuan dan keterampilan siswa, uji Wilcoxon p<0,005. Peserta pelatihan sudah mampu menjadi narasumber di webinar di sekolah masing-masing. Kegiatan pelatihan dan pendampingan secara signifikan meningkatkan pengetahuan dan pemahaman peserta dan meningkatkan jejaring PPKS universitas YARSI.
FRAUD DIAMOND FOR DETECTION OF FINANCIAL STATEMENT MISREPRESENTATION IN THE MANUFACTURING INDUSTRY
Authors:   PKN STAN Indonesia, Mentari Rizqi Ayu , Sopian Sopian ,   PKN STAN Indonesia
Published: January 2023

This research was conducted to obtain empirical evidence regarding fraud, primarily due to fraud in financial reports based on the fraud diamond theory. This study tested six independent variables; financial stability, external pressure, financial targets, effective monitoring, rationalization, and capability. P-Score Model is used to detect potential fraudulent financial statements. The objects studied were 103 manufacturing companies listed on the Indonesia Stock Exchange (IDX) in 2015-2019 with 515 annual reports. The results of this study indicate that only two variables have an effect in detecting fraud in financial statements. The variables that have a significant effect are financial stability as proxied by the ratio of changes in assets and financial targets as proxied by the ratio of return on assets (ROA). Other variables represented by external pressure, effective monitoring, rationalization, and capability did not affect the detection of potential fraudulent financial statements. These findings may benefit auditors in predicting fraud in financial statements, considering the fraud diamond environment.
THE SOP ANALYSIS AND DESIGN OF INCOME REPORTING SYSTEM FROM ARTICLE 21 AND 23
Authors:   Widya Mandala Surabaya Catholic University Indonesia, Haki Elisabeth Yuliana , Handoko Jesica ,   Widya Mandala Surabaya Catholic University Indonesia
Published: January 2023

The object of research is PT PMTextile which is engaged in the textile industry. The company's SOP is irrelevant to the company's current practices and is not yet in accordance with tax regulations. This research aims to analyze and redesign the SOP of the income tax reporting system article 23 and 21. The problems are there is no SOP correction of periodic income tax return, there is no authorization, the documents are still less relevant, references to SOP regulations and policies are not appropriate. Lastly, there is no independent checking, the signing of tax returns and SOP of income tax reporting article 23 has not used e-bupot. This research aims to analyze and redesign the SOP to improve internal control. This research uses a type of qualitative descriptive research. The result is to adjust the company's SOP to the company's condition and redesign it, add checking and authorization activities, changes in document flow, adjustment of references to regulations and policies SOP in accordance with tax regulations, and the proposed SOP correction of periodic income tax return article 23 and 21. PT PMTextile is expected to conducts a routine evaluation of its SOP and update tax regulations.
First evidence of ranavirus in native and invasive amphibians in Colombia
Authors: Flechas SV , Urbina J , Crawford AJ , Gutiérrez K , Corrales K , Castellanos LA , González MA , Cuervo AM , Catenazzi A
Published: January 2023

Ranaviruses can cause mass mortality events in amphibians, thereby becoming a threat to populations that are already facing dramatic declines. Ranaviruses affect all life stages and persist in multiple amphibian hosts. The detrimental effects of ranavirus infections to amphibian populations have already been observed in the UK and in North America. In Central and South America, the virus has been reported in several countries, but the presence of the genusRanavirus (Rv)in Colombia is unknown. To help fill this knowledge gap, we surveyed forRvin 60 species of frogs (including one invasive species) in Colombia. We also tested for co-infection withBatrachochytrium dendrobatidis(Bd)in a subset of individuals. ForRv, we sampled 274 vouchered liver tissue samples collected between 2014 and 2019 from 41 localities covering lowlands to mountaintop páramo habitat across the country. Using quantitative polymerase chain reaction (qPCR) and end-point PCR, we detectedRvin 14 individuals from 8 localities, representing 6 species, including 5 native frogs of the generaOsornophryne, PristimantisandLeptodactylus, and the invasive American bullfrogRana catesbeiana.Bdwas detected in 7 of 140 individuals, with 1 co-infection ofRvandBdin anR. catesbeianaspecimen collected in 2018. This constitutes the first report of ranavirus in Colombia and should set off alarms about this new emerging threat to amphibian populations in the country. Our findings provide some preliminary clues about how and whenRvmay have spread and contribute to understanding how the pathogen is distributed globally.
Costs of parthenogenesis on growth and longevity in ex situ zebra sharks Stegostoma tigrinum
Authors: Adams L , Lyons K , Monday J , Larkin E , Wyffels J
Published: January 2023

The zebra shark Stegostoma tigrinum, a popular aquarium fish, is an endangered species that is known to readily reproduce both sexually and through facultative parthenogenesis while in human care. Artificial insemination trials that took place between 2011 and 2013 resulted in the hatching of 2 sexually produced (herein heterozygotes) and 10 parthenogenetic sharks that allowed for a retrospective comparison of growth, feeding and longevity between offspring produced from 2 distinct reproductive modes. Parthenogenetic offspring were generally smaller at hatch than their heterozygous counterparts and, after the first several months post-hatch, failed to increase in mass and length at the same rate as heterozygotes. Parthenogenetic offspring exhibited non-normal swimming behaviors such as spiraling, spy hopping and head standing, which may have been correlated with a gradual decline in the ability of some sharks to properly suction feed. Median lifespan for the parthenotes was 1.05 yr (range: 0.27-6.64 yr); one of the heterozygotes lived to 2.37 yr of age, and the other was alive at the time of this writing in August 2022 and had reached reproductive maturity. By contrast, the 2 longest surviving parthenotes perished just prior to reaching sexual maturity (~5.5 and ~6.5 yr). Parthenogenesis has been documented among ex situ S. tigrinum maintained in aquariums across the globe, and this study demonstrates substantial negative costs to fitness in parthenogenetic offspring compared with their heterozygous siblings. The reduced fitness of parthenotes has implications for managing populations in human care as well as for in situ conservation efforts.
The Appearance and Implementation of Human Rights
Authors:   University–Galati–Romania, Legal Research Institute–Romanian Academy, ESIL and ELI member, Lower Danube, Romania, E–mails: maghenitei@gmail.com & Mihaela. Aghenitei@ugal.ro, Agheniței Mihaela , Jafar Samdani Lawyer ,   The Legal Canter–Kuwait (L.L.P), E–mails: jafarsamdani@yahoo.com & Jafar.s@legalcenter.com.kw
Published: January 2023

The European Convention for the Protection of Human Rights and Fundamental Freedoms has created an international monitoring mechanism in addition to national mechanisms
Atypical Genetic Autism: Cure of the Major Autistic Features and the Need for Cognitive Improvement and Rehabilitation
Authors:   Advisor in Pediatrics and Pediatric Psychiatry and expert trainer, The National Training and Development Center and Baghdad Medical City, Iraq., Jalal Al–Mosawi Aamir
Published: January 2023

Background: We have previously reported our extensive experiences with autism disorders and their treatments, and we showed the possibility of curing the major autistic features with a new therapeutic approach
Cerebral Palsy and Autism Associated With Periventricular White Matter Hyperintensity on Brain Magnetic Resonance Imaging: A New Disorder and Its Treatment
Authors:   Advisor in Pediatrics and Pediatric Psychiatry and expert trainer, The National Training and Development Center and Baghdad Medical City, Iraq., Jalal Al–Mosawi Aamir
Published: January 2023

Background: We have previously reported the very rare sporadic occurrence of periventricular white matter hyperintensity on brain magnetic resonance imaging with atypical neuropsychiatric
In Silico Binding Analysis of Cannabinoids with Eph Receptors for Therapeutic Use in Gliomas
Authors:   Montville, NJ, United States, Batchu Sai , Joseph Diaz Michael ,   College of Medicine, University of Florida, Gainesville, FL, United States., Lucke–Wold Brandon ,   Department of Neurosurgery, University of Florida, Gainesville, FL, United States.
Published: January 2023

Background: Accumulating evidence suggests overexpression of Eph receptors is associated with malignant human gliomas.
The Potential Benefit of Improving Health Literacy to Reduce Socioeconomic Inequities in Adolescent Health and Educational Outcomes.
Authors:   Centre for Community Child Health, Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, Australia. Email: jun.guo@mcri.edu.au., Guo Shuaijun , Yu Xiaoming ,   Institute of Child and Adolescent Health, School of Public Health, Peking University, China. Email: yxm@bjmu.edu.cn., He Fan ,   The John Richards Centre for Rural Ageing Research, La Trobe Rural Health School, La Trobe University, Australia. Email: F.He@latrobe.edu.au., Davis Elise ,   Melbourne School of Population and Global Health, University of Melbourne, Australia. Email: elise.davis@summerfoundation.org.au(ED);Rebecca.rmstrng@gmail. com(RA);l.naccarella@unimelb.edu.au(LN)., Armstrong Rebecca ,   Melbourne School of Population and Global Health, University of Melbourne, Australia. Email: elise.davis@summerfoundation.org.au(ED);Rebecca.rmstrng@gmail. com(RA);l.naccarella@unimelb.edu.au(LN)., Naccarella Lucio ,   Melbourne School of Population and Global Health, University of Melbourne, Australia. Email: elise.davis@summerfoundation.org.au(ED);Rebecca.rmstrng@gmail. com(RA);l.naccarella@unimelb.edu.au(LN).
Published: January 2023

Background: Exposure to early socioeconomic disadvantage is associated with a range of adverse health and educational outcomes in later life, leading to substantial social and economic costs.
Derrame de petróleo, un desastre ecológico: revisión bibliográfica sobre su impacto en la salud
Authors: Ordóñez Carol , Vásquez-Velásquez Cinthya , Gonzales Gustavo F.
Published: January 2023

El petróleo está constituido principalmente por hidrocarburos y metales, en distintas concentraciones. Su naturaleza es altamente inflamable y a lo largo de la historia ha sido usado como combustible y fuente energética. Los derrames de petróleos son desastres que alteran distintos pisos ecológicos y afectan distintos sectores, principalmente el ambiental, el de salud, la economía y el turismo. Diversos estudios han evidenciado efectos tanto a corto como a largo plazo en la salud humana, especialmente a nivel reproductivo, cardio-respiratorio, hepático, renal, metabólico y mental. La exposición ocurre por ingestión, absorción a través de la piel intacta e inhalación. En Perú, el 15 de enero de 2022, un derrame de petróleo en Ventanilla, Callao, de alrededor de 12,000 barriles de petróleo generó efectos nocivos sobre especies marinas, ornitológicas y sobre la calidad de vida de pescadores artesanales. Su impacto aún está en evaluación debido a que a ello se suma lenta respuesta de los responsables por mermar el avance del derrame en la zona, habiéndose extendido 34.4 km hasta la zona de Chancay. Es por ello, que en la presente revisión se detalla la evidencia científica a nivel internacional de los efectos principalmente en la salud, que puede generar un derrame de petróleo. Los hallazgos reportados en la literatura contribuyen a ampliar el conocimiento sobre los efectos a largo plazo de los derrames de petróleo en la salud, considerando la necesidad de estudios longitudinales en especies y poblaciones aledañas a las zonas directamente afectadas por estos desastres ecológicos.
PREVALENCE OF HUMAN PAPILLOMA VIRUS AMONG PATIENTS WITH SEXUALLY TRANSMITTED INFECTIONS
Authors:   SЕ «Institute of Dermatology and Venereology of NAMS of Ukraine», Osinska T. V.
Published: January 2023

The affinity of sources of infection, dominance of sexual transmission, as well as the contingent of persons at risk of sexually transmitted infections (STIs) and human papilloma virus (HPV), determines the possibility of simultaneous infection with pathogens of these diseases. The aim of the study was to study the prevalence of highly oncogenic (HO) types of human papilloma virus among sick women with sexually transmitted infections and opportunistic flora (UTI). Materials and methods. The frequency of detection of highly oncogenic human papillomavirus types and their genotypes was assessed in 44 women (mean age 32.6 years) with chronic endocervicitis of mixed etiology using real-time polymerase chain reaction (PCR). Results. The initial prevalence (59.1%) of highly oncogenic human papillomavirus genotypes (16, 18, 31, 35, 45, 56, 58, 59, 66, 68, 82) was found among women of childbearing age with endocervicitis of Trichomonas etiology in combination with other (68.2%) sexually transmitted infections (chlamydia – 18.1%, ureaplasmosis – 25%) and opportunistic flora (86.4%), with a predominance of human papilloma virus type 16 (18.1%) and type 45 (15.9%). Conclusions. Diagnosing co-infection with sexually transmitted infections, opportunistic pathogens, and highly oncogenic types of human papillomavirus is an important factor in detecting cervical cancer.
DEFINITION OF FRONTAL FIBROSING ALOPECIA IN THE GROUP OF SCARRING ALOPECIAS
Authors:   Shupyk National Healthcare Univercity of Ukraine, Kaliuzhna L. D. , Petrenko A. V. ,   Shupyk National Healthcare Univercity of Ukraine
Published: January 2023

The paper presents the cases of frontal fibrosing alopecias in two postmenopausal women. Frontal fibrosing alopecia is a lymphocytic cicatricial alopecia characterized by progressive recession of the frontotemporal hairline. The disease also commonly causes loss of the eyebrows and loss of hair on the extremities. Histopathology is the gold-standard for diagnosis but not ideal for monitoring given the invasive nature.
PENERAPAN SPONGE CITY PADA KAWASAN KAMPUNG MANGGARAI, JAKARTA
Authors: Larasati Finky , Tanjung Fadly , Haq Harun , Afif Irfan
Published: January 2023

Padatnya kawasan perkotaan akibat pertumbuhan penduduk menyebabkan timbulnya permukiman kumuh. Kondisi ini sering dijumpai pada permukiman yang berada di sempadan sungai Provinsi DKI Jakarta, khususnya Kampung Manggarai. Keberadaan lahan permukiman ini berdampak pada perubahan proporsi tutupan lahan, sehingga mengurangi area resapan air. Studi ini mengaplikasikan konsep sponge city yang telah disesuaikan dengan kebutuhan wilayah studi. Metode pengumpulan data dilakukan dengan wawancara, observasi, dan perolehan data sekunder. Metode analisis dilakukan dengan membandingkan kriteria ketiga elemen rencana, yaitu (a) Green Neighborhood (b) Permeable Road (c) Utility terhadap kondisi eksisting menggunakan metode gap analysis untuk menghasilkan rekomendasi. Studi ini dilakukan dengan merancang sebuah kawasan kumuh untuk menyelesaikan persoalan banjir. Beberapa rekomendasi yang dapat dilakukan diantaranya: (1) Penambahan area resapan air; (2) Penataan daerah terbangun dengan penyediaan bangunan hunian vertikal; (3) Pengaplikasian konstruksi jalan dengan material ramah lingkungan dan memiliki daya resap air yang tinggi seperti permeable paving block; (4) Penyediaan fasilitas manajemen limpasan air hujan seperti sumur resapan, bioswales, dan kolam retensi.
Dynamic analysis and optimal control of COVID-19 with comorbidity: A modeling study of Indonesia
Authors: Rois Muhammad Abdurrahman , Fatmawati  , Alfiniyah Cicik , Chukwu Chidozie W.
Published: January 2023

Comorbidity is defined as the coexistence of two or more diseases in a person at the same time. The mathematical analysis of the COVID-19 model with comorbidities presented includes model validation of cumulative cases infected with COVID-19 from 1 November 2020 to 19 May 2021 in Indonesia, followed by positivity and boundedness solutions, equilibrium point, basic reproduction number (R0), and stability of the equilibrium point. A sensitivity analysis was carried out to determine how the parameters affect the spread. Disease-free equilibrium points are asymptotically stable locally and globally if R0 < 1 and endemic equilibrium points exist, locally and globally asymptotically stable if R0 > 1. In addition, this disease is endemic in Indonesia, with R0 = 1.47. Furthermore, two optimal controls, namely public education and increased medical care, are included in the model to determine the best strategy to reduce the spread of the disease. Overall, the two control measures were equally effective in suppressing the spread of the disease as the number of COVID-19 infections was significantly reduced. Thus, it was concluded that more attention should be paid to patients with COVID-19 with underlying comorbid conditions because the probability of being infected with COVID-19 is higher and mortality in this population is much higher. Finally, the combined control strategy is an optimal strategy that provides an effective guarantee to protect the public from the COVID-19 infection based on numerical simulations and cost evaluations.
Antibacterial quaternary ammonium chitosan/carboxymethyl starch/alginate sponges with enhanced hemostatic property for the prevention of dry socket
Authors: Deng Xuyang , Wang Danyang , Zhang Dongjie , Sun Ming , Zhou Liying , Wang Yuxi , Kong Xiaowen , Yuan Changqing , Zhou Qihui
Published: January 2023

Tooth extraction commonly leads to postoperative wound bleeding, bacterial infection, and even the occurrence of dry socket. Therefore, developing a biomedical material with favorable antibacterial and excellent hemostatic properties to prevent the post-extraction dry socket is necessary. Herein, quaternary ammonium chitosan/ carboxymethyl starch/alginate (ACQ) sponges are developed via Ca2+ cross-linking, electrostatic interaction, and lyophilization methods. The results show that the bio-multifunctional sponges exhibit interconnected porous structures with significant fluid absorption rates and suitable water vapor transmission rates. In vitro cellular and hemolysis experiments indicate that the developed sponges have acceptable biocompatibility. Notably, the constructed sponges effectively inhibit the growth of E. coli, S. aureus, and C. albicans, as well as achieve rapid hemostasis in the mouse liver injury and mini-pig tooth extraction models by absorbing blood and promoting red blood cell adhesion. Thus, the created bio-multifunctional sponges show tremendous promise as a hemostatic material for wound management after tooth extraction.
A metaphor analysis of older adults' lived experience of household isolation during COVID-19
Authors: Wilding Ell , Bartl Sara , Littlemore Jeannette , Clark Maria , Brooke Joanne
Published: January 2023

In March 2020, Public Health England provided social distancing and shielding guidance for all adults aged 70 and over in response to the COVID-19 pandemic. This article seeks to provide insight into the lived experiences of older people during this period of household isolation. To do so, we analysed the metaphors used by 13 older adults during interviews discussing their experiences of household isolation, focusing on how these metaphors relate to a loss of agency. We found that participants negotiated their sense of agency through the use of metaphors involving physical force, movement, space, and animation of COVID-19. Metaphors were particularly used to discuss negative emotional impacts of the pandemic. Perceptions of a loss of agency were sometimes redressed through the use of comforting metaphors involving patterns and structure. In addition, participants explicitly rejected or refashioned dominant public metaphors that circulated as part of Government campaigns and wider public discourse to describe the pandemic and encourage certain behaviors. It has been argued that commonly used metaphors relating to containment, e.g., “bubble”, when applied to the context of household isolation, foreground the actions of those outside the container rather than those inside it, leading to a loss of feelings of agency. The participants' reactions to these suggest that common metaphors in public discourses are appropriated selectively and challenged by those at whom they are targeted. Hence, metaphor analysis can be used to paint a rich picture of the lived experience of older people experiencing household isolation, including their reaction to dominant public metaphors.
Are acute type A aortic dissections atherosclerotic?
Authors: Grewal Nimrat , Dolmaci Onur , Jansen Evert , Klautz Robert , Driessen Antoine , Lindeman Jan , Poelmann Robert E.
Published: January 2023

Background

Type A aortic dissections (TAAD) are devastating aortic complications. Patients with Marfan syndrome, a bicuspid aortic valve or a thoracic aortic aneurysm have an increased risk to develop a TAAD. These predisposing conditions are characterized by a histologically thin intimal layer and hardly any atherosclerosis. Little is known about the susceptibility for atherosclerosis in patients with a type A aortic dissection.

Objective

We aim to systematically describe atherosclerotic lesions in TAAD patients.

Materials and methods

A total of 51 patients with a TAAD (mean age 62.5 ± 10.8 years, 49% females) and 17 control patients (mean age 63 ± 5.5 years, 53% females) were included in this study. Cardiovascular risk factors were assessed clinically. All sections were stained with Movat pentachrome and hematoxylin eosin. Plaque morphology was classified according to the modified AHA classification scheme proposed by Virmani et al.

Results

In the TAAD group thirty-seven percent were overweight (BMI > 25). Diabetes and peripheral arterial disease were not present in any of the patients. Fifty-nine percent of the patients had a history of hypertension. The intima in TAAD patients was significantly thinner as compared to the control group (mean thickness 143 ± 126.5 μm versus 193 ± 132 μm, p < 0.023). Seven TAAD patients had a normal intima without any form of adaptive or pathological thickening. Twenty-three TAAD patients demonstrated adaptive intimal thickening. Fourteen had an intimal xanthoma, also known as fatty streaks. A minority of 7 TAAD patients had progressive atherosclerotic lesions, 4 of which demonstrated pathological intimal thickening, 3 patients showed early fibroatheroma, late fibroatheroma and thin cap fibroatheroma. In the control group the majority of the patients exhibited progressive atherosclerotic lesions: three pathologic intimal thickening, two early fibroatheroma, six late fibroatheroma, one healed rupture and two fibrotic calcified plaque.

Discussion

This study shows that TAAD patients hardly exhibit any form of progressive atherosclerosis. The majority of TAAD patients showcase non-progressive intimal lesions, whereas the control group mostly demonstrated progressive intimal atherosclerotic lesions. Findings are independent of age, sex, or the presence of (a history of) hypertension.
Causal association of peripheral immune cell counts and atrial fibrillation: A Mendelian randomization study
Authors: Feng Yuntao , Liu Xuebo , Tan Hongwei
Published: January 2023

Background

Atrial fibrillation (AF) is the most common and persistent form of arrhythmia. Recently, increasing evidence has shown a link between immune responses and atrial fibrillation. However, whether the immune response is a cause or consequence of AF remains unknown. We aimed to determine whether genetically predicted peripheral immunity might have a causal effect on AF.

Methods

First, we performed Mendelian randomization (MR) analyses using genetic variants strongly associated with neutrophil, eosinophil, basophil, lymphocyte, and monocyte cell counts as instrumental variables (IVs). Lymphocyte counts were then subjected to further subgroup analysis. The effect of immune cell counts on AF risk was measured using summary statistics from genome-wide association studies (GWAS).

Results

Two-sample MR analysis revealed that a higher neutrophil count, basophil count and lymphocyte count had a causal effect on AF [Odds ratio (OR), 1.06, 95% confidence interval (CI), 1.01–1.10, P = 0.0070; OR, 1.10; 95% CI, 1.04–1.17; P = 0.0015; OR, 0.96; 95% CI, 0.93–0.99; P = 0.0359]. In addition, in our further analysis, genetically predicted increases in CD4 + T-cell counts were also associated with an increased risk of AF (OR, 1.04; 95% CI, 1.0–.09; P = 0.0493).

Conclusion

Our MR analysis provided evidence of a genetically predicted causal relationship between higher peripheral immune cell counts and AF. Subgroup analysis revealed the key role of peripheral lymphocytes in AF, especially the causal relationship between CD4 + T cell count and AF. These findings are beneficial for future exploration of the mechanism of AF.
Lessons learned from 10 years of experience with minimally invasive cardiac surgery
Authors: El-Sayed Ahmad Ali , Salamate Saad , Bakhtiary Farhad
Published: January 2023

Since its inception more than a quarter of a century ago, minimally invasive cardiac surgery has attracted the increasing interest of cardiac surgeons worldwide. The need to surgically treat patients with smaller and better-tolerated incisions coupled with high-quality clinical outcomes, particularly in structural heart disease, has become imperative to keep pace with the evolution of transcatheter valve implantation. We have learned numerous lessons from our longstanding experience in this field of surgical care, especially in terms of endoscopic access via mini-thoracotomy. To improve the safety and efficacy of this minimally invasive endoscopic access, this study summarizes and highlights the lessons we have learned, acting as a template for newly established cardiac surgeons in minimally invasive techniques.
Extensive responses of lake dynamics to climate change on northeastern Tibetan Plateau
Authors: Liu Wenhui , Liu Hairui , Li Qingpeng , Xie Changwei , Zhang Zhijun , Zhou Guanghao , Zhang Qi , Zhao Qinhao
Published: January 2023

The lakes on the Qinghai–Tibetan Plateau have undergone substantial changes. As intensive cryospheric components change, the response of the lake dynamics to climatic factors, glacier-snow melting, and permafrost thawing has been complex. Based on Landsat images, meteorological data, and glacier and permafrost data, the spatial-temporal changes in the lake area on the northeastern Tibetan Plateau between 1988 and 2019 were analyzed and the driving factors behind the lake changes were further explored. The results suggest that the regional lake area increased from 1988 to 2019 at rates of 0.01–16.03 km2/yr. It decreased during 1988–2000, quickly increased during 2000–2012, and rapidly increased during 2012–2019. The most significant lake expansion occurred in sub-region I, which is the source region of the Yangtze River Basin. There was a sharper increase during 2012–2019 than during 2000–2012 in sub-region II (the source region of the Yellow River Basin and the Qinghai Lake Basin) and sub-region III (the Qaidam Basin). The significant lake expansion occurred about 12 years earlier in sub-region I than in sub-regions II and III. This dramatic change in the lake area was closely associated with the annual precipitation, and precipitation was the primary driving factor. Although serious glacier retreat occurred, most of the lakes in the sub-regions were non-glacier-fed lakes. The correlation between glacier ablation and the change in the lake area was poor, which suggests that glacial meltwater was not the replenishment source of most of the lakes in this region. A more accelerated increase in the active layer thickness occurred (1.90 cm/yr), which was consistent with the more rapid lake expansion, and the permafrost degradation further intensified the lake expansion.
Gas oversaturation in deep coals and its implications for coal bed methane development: A case study in Linxing Block, Ordos Basin, China
Authors: Kang Yongshang , Huangfu Yuhui , Zhang Bing , He Zhiping , Jiang Shanyu , Ma Yuan Zee
Published: January 2023

Three coal bed methane (CBM) wells penetrating to coal seams 8+9# (Permian Taiyuan Formation), in deep coals (depth>1,500 m), show very differential production performance in Linxing Block, eastern margin of the Ordos Basin in China. The mechanism for the performance differentiation is analyzed through studies on coal permeability and gas saturation in deep coals, and specifically, the comparison of coal reservoir characteristics in the three wells. The mechanism for gas oversaturation is then discussed based on data from Linxing Block and spot but important exploration results relevant to deep coals in the Junggar Basin. This study demonstrates that: (1) Permeability values of coal seams 8+9# in deep coals are probably in the order of 10−2mD from diverse sources including results of experimental permeability test simulating underground stress conditions. Studies on gas saturation distribution reveal that high gas rates (>3,000 m3/d) can be achieved only from oversaturated coal reservoirs in Linxing Block. (2) Two types of oversaturation mechanism, including igneous intrusion-driven oversaturation and sorption capacity-driven oversaturation, exist in deep coals. The former is restricted to regions/blocks influenced by igneous intrusion, and characterized by secondary gas generation and supplementation to deep coals that have substantial similar Langmuir curves to that of shallow coals. The latter may play in deep coals that are not influenced by igneous intrusion, and is characterized by more free gas released from coals after adsorption saturation, due to reduced sorption capacity in deep coals; (3) Oversaturation may exist more frequently in deep coals (in comparison with shallow coals), due to mostly the sorption capacity-driven oversaturation mechanism, and the weaker tectonic deformation and uplifting experienced by deep coals in comparison with shallow coals, which favors gas preservation and oversaturation. (4) Generally, coal permeability in deep coals is low due to the increased effective stress, and exploring oversaturation areas should be a primary concern for CBM development. It appears that in most large, tectonically compressed coal basins, there is a critical depth beyond which the oversaturation areas could occur, presenting opportunities and challlenges for CBM development.