bluuebunny/crossref_metadata_2025 huggingface dataset:
Intersecting sex and gender diversity with sexual rights for people living with dementia in later life: an example of developing a learning framework for policy and practice
Authors: Hafford-Letchfield Trish
Published: January 2024

The proliferation of literature on dementia over the last decade has begun to address the experience of LGBTQ+ people's experiences in later life. Changes in cognitive function can jeopardize the safety, wellbeing, and human rights of LGBTQ+ people if the social care workforce are not prepared or versed in responding to their unique needs. The intersection of age, cognitive function, sexual and gender diversity with the expression of intimacy and sexuality requires sensitive and respectful consideration. Yet, this is currently an under-researched and less understood area in social care practice. This paper highlights the main messages from the different bodies of contributory literature and introduces the national framework in England UK on LGBTQ+ aging and its potential for supporting workforce development to consider its flexibility in supporting services to becoming more nuanced and affirmative in these areas of practice.
Computational fluid dynamics modelling and optimization of solar powered direct contact membrane distillation with localized heating for off-grid desalination
Authors: Samadi Akbar , Samadi Shahla , Di Profio Gianluca , Zhao Shuaifei , Fontananova Enrica
Published: January 2024

Introduction: Membrane distillation (MD) is a promising technique for desalination, capable of utilizing low-grade heat. However, MD faces some challenges such as temperature polarization. To overcome these issues, direct solar MD with localized heating (LHMD) has emerged as a cost-effective and efficient solution by leveraging solar energy.

Methods: This study focuses on process optimization of LHMD using computational fluid dynamics (CFD) modeling. CFD simulation was applied to investigate the fluid behavior, heat transfer, and mass transfer within the system. Several key factors, including module geometry, process configuration, solar irradiation, feed flow rate, and feed temperature are investigated.

Results: The effects of these parameters on the distillate production rate, thermal behavior, and energy efficiency, are evaluated for optimization. At the optimal conditions, 1 m2 membrane in a module with a length of 50 cm and a channel height of 1.5 mm under a counter-current flow generates 12 L drinking water per day, which meets the basic drinking water demands for 6 people. Over 70% gain output ratio can be achieved when the feed temperature is more than 20°C, the feed velocity is 1–1.5 mm/s, and the feed salinity is less than 1000 mol·m−3. This setup can also produce 6 L of distilled water per day when a water with a salinity six times higher than seawater if the feed velocity is sufficiently low.

Discussions: The main feature of the localized heating is the reverse temperature polarization on the feed side, leading to the increase in energy efficiency and the ease of scale-up.
Assessment of multidimensional self-concept in the area of physical education: validation of a scale
Authors: Galán-Arroyo Carmen , Gomez-Paniagua Santiago , Castillo-Paredes Antonio , Rojo-Ramos Jorge
Published: January 2024

Introduction

Self-concept is a person's perception of him/herself and how he/she performs in different situations. This aspect must be developed during the formative stages and Physical Education is a fundamental area due to its enormous methodological possibilities.

Aim

Therefore, the aim of this study is to evaluate the factor structure and reliability of an instrument that allows to analyze the multidimensional self-concept of high school students in the context of Physical Education.

Method

The sample consisted of 1,155 secondary school students from public schools in the Autonomous Community of Extremadura, Spain. After the exploratory and confirmatory analyses, a structure composed of 30 items divided into 5 factors was.

Results

This design showed excellent goodness-of-fit indices as well as good internal reliability indicators (Cronbach's Alpha = 0.76 – 0.88).

Conclusion

Therefore, this scale can be considered as a tool to assess the self-concept of high school students in a quick and easy way.
Effects of neoadjuvant zoledronate and radiation therapy on cell survival, cell cycle distribution, and clinical status in canine osteosarcoma
Authors: Norquest Carissa J. , Rogic Anita , Gimotty Phyllis A. , Maitz Charles A. , Rindt Hansjorg , Ashworth Hayley L. , Bryan Jeffrey N. , Donnelly Lindsay L. , McCleary-Wheeler Angela L. , Flesner Brian K.
Published: January 2024

Introduction

Zoledronic acid (ZOL) is a third-generation bisphosphonate with a higher affinity for bone resorption areas than earlier bisphosphonates (i.e., pamidronate, PAM). In human medicine, ZOL provides improved bone pain relief and prolonged time to skeletal-related events compared to its older generational counterparts. Preclinical studies have investigated its role as an anti-neoplastic agent, both independently and synergistically, with radiation therapy (RT). ZOL and RT act synergistically in several neoplastic human cell lines: prostate, breast, osteosarcoma, and fibrosarcoma. However, the exact mechanism of ZOL’s radiosensitization has not been fully elucidated.

Methods

We investigated ZOL’s ability to induce apoptosis in canine osteosarcoma cell lines treated with various doses of megavoltage external beam radiotherapy. Second, we evaluated cell cycle arrest in ZOL-treated cells to assess several neo-adjuvant time points. Finally, we treated 20 dogs with naturally occurring appendicular OS with 0.1 mg/kg ZOL IV 24 h before receiving 8 Gy of RT (once weekly fraction x 4 weeks).

Results

We found that apoptosis was increased in all ZOL-treated cell lines compared to controls, and the combination of ZOL and RT resulted in dissimilar apoptosis between Abrams and D-17 and HMPOS cell lines. Cell cycle arrest (G2/M phase) was minimal and variable between cell lines but perhaps greatest at 48 h post-ZOL treatment. Only 10% of dogs treated with ZOL and RT developed pathologic fractures, compared to 44% of dogs historically treated with PAM and RT (p = 0.027).

Discussion

ZOL and RT appear to be a well-tolerated combination treatment scheme for non-surgical candidates; future studies must elucidate the ideal timing of ZOL.
Lactation performances in primiparous Holstein cows following short and normal gestation lengths
Authors: Probo Monica , Atashi Hadi , Hostens Miel
Published: January 2024

Despite decades of research, little is known regarding physiologic temporal limits for initiation of lactation in pregnant non-lactating cattle the aim of this study was to compare the lactation performances in primiparous Holstein cows after a short gestation length (GL) or abortion to those after a normal GL. The data were collected using an automated data collection system. The 94 herds evaluated were located in Belgium, France, Italy, the Netherlands and Germany. Data from a wide range of physiological cow-life events including birth and calving events, reproduction events (insemination, pregnancy checks, and abortions), and milking events were collected. The GL was defined as the interval between the last insemination and the subsequent calving (or abortion) within a range of 150–297 days. Animals were categorized into one of five categories based on GL quantiles (C-I to C-V). Lactation curve parameters including the scale, ramp, and decay were estimated using the Milkbot model. Then, the derived 305-day milk yield (M305-d), peak yield, and time to peak were compared between different GL categories. Of 13,732 lactations, 15 (0.11%) were found with a GL shorter than 210 days (ranging from 158 to 208 days). The 305-day milk yield was significantly lower in the C-I (7,566 ± 186) and C-II groups (7,802 ± 136 kg), compared to the C-III (8,254 ± 116 kg), C-IV (8,148 ± 119 kg), and C-V (8,255 ± 117 kg) groups. The same trends were found for the scale and peak yield of the lactation; the lowest scale were found for the C-I (31.5 ± 0.73) and C-II (32.8 ± 0.53) groups, and the highest were found for the C-III (34.5 ± 0.46), C-IV (34.9 ± 0.45), and C-V (35.0 ± 0.45) groups. Peak yield increased significantly from C-I (27.8 ± 0.66 kg) and C-II group (28.8 ± 0.48 kg) to the C-III (30.2 ± 0.42 kg) and further to the C-IV (30.6 ± 0.40 kg) and C-V (30.6 ± 0.41 kg) groups. Moreover, primiparous cows in the C-II GL category showed a higher milk yield persistency (decay of 1.30E−4 ± 3.55E−5) compared to those belonging to the C-IV (decay of 1.38E−4 ± 2.51E-5) and C-V (decay of 1.38E−4 ± 2.58E-5) group. In conclusion, results showed that primiparous cows with a shorter GL produced significantly less 305-day milk and peak yields, had a higher lactation persistency, and showed a lower upward slope of the lactation curve compared to those with a normal GL.
A Simplified Model for the Study of Film-Boiling Droplet Motion on Microscale Ratchets
Authors: Wang Sheldon , Ok Jeong Tae , Park Sunggook , Elsharafi Mahmoud , Guo Yu
Published: January 2024

In this work, we explore a simplified model based on both analytical and computational methods for the study of film-boiling droplet motion on microscale ratchets. We consider a specific ratchet design with the length periods and depth of ratchets much smaller than the size of the droplet. We conclude based on our modeling that for the ratchet configuration considered in this paper, the conduction within the vapor film is the dominant means of heat transfer in comparison with convection and radiation. Furthermore, we demonstrate a more manageable two-dimensional model in which analytical approaches coupled with computational approaches yield reasonably accurate results in comparison to the actual experiments.
First Description of Simplicillium lanosoniveum, a Potential Antagonist of the Coffee Leaf Rust from Cuba
Authors: Baró Robaina Yamilé , González Marrero Isel , Lorenzo Nicao María Elena , Castañeda Ruiz Rafael F. , Li De-Wei , Ponce de la Cal Amaia , Ben Gharsa Haifa , Manfrino Romina G. , Schuster Christina , Leclerque Andreas
Published: January 2024

(1) The fungal genus Simplicillium (Cordycipitaceae: Hypocreales) has an extensive distribution and a broad spectrum of hosts and substrates. The species Simplicillium lanosoniveum is a mycoparasite with potential for biological control of coffee leaf rust, Hemileia vastatrix. Morphologically, Simplicillium closely resembles mycoparasitic and entomopathogenic Lecanicillium fungi, often resulting in misidentification. A fungal isolate was obtained from leaf-rust-infested coffee plants from Cienfuegos Province, Cuba. (2) Combined analyses of morphology and molecular markers (ITS, LSU, EF-1alpha) were used for fungal identification. (3) In the NJ, ML, and BI phylogenies which were reconstructed, the isolate LBSim-01 was located in the Simplicillium lanosoniveum clade. This species-level identification was supported by morphological features. (4) The isolate LBSim-01 was assigned to the species Simplicillium lanosoniveum. This is the first description of a Simplicillium fungus associated with coffee leaf rust in Cuba. The presented results hold implications for the biological control of this economically relevant plant disease.
Mapping Selected Emergent Marine Toxin-Producing Organisms Using Historical Samples with Two Methods (Biosensors and Real-Time PCR): A Comparison of Resolution
Authors: Mengs Gerado , Stern Rowena F. , Clarke Jessica L. , Faith Matthew , Medlin Linda K.
Published: January 2024

The Continuous Plankton Recorder (CPR) survey is a valuable resource for mapping changes in plankton distribution and understanding harmful algal ecology because of its breadth and longevity. Preservation methods with formalin degrade DNA, making it difficult to use as a molecular tool for archived marine samples. DNA was extracted from CPR samples immediately after collection, seven months later and after nine years of storage from a cruise track along the Iberian Peninsula. PCR reactions performed from the nine-year timepoint were hybridized to probes in an electrochemical biosensor and compared to results obtained from RT-PCR performed at two earlier time points. The successful identification of Pseudo-nitzschia spp., Prorocentrum lima, Alexandrium minutum, Alexandrium ostenfeldii, Gambierdiscus spp. and Coolia spp. was documented. The biosensor analysis outperformed RT-PCR, allowing us to document certain tropical toxic dinoflagellates, viz., Gambierdiscus and Coolia, that produce human ciguatoxins and Coolia toxins, respectively. These non-native algal toxins can accumulate, pervade the food web and negatively impact human food security. This supports the northerly movement of microalgae with climate change in offshore Iberian peninsular waters. This study highlights biosensors as a cost-effective tool for the offshore monitoring of HAB species and advances molecular technologies for long-term CPR datasets that have limited records of harmful algae. DNA from formalin-preserved CPR samples is degraded, so the use of a short, multiprobe biosensor can augment historical plankton records with contemporary methods that also capture infrequently occurring benthic taxa carried in surface waters. The integration of probe-based biosensor technologies offers a promising avenue for exploring plankton dynamics in response to environmental changes.
Stability Analysis in a Mathematical Model for Allergic Reactions
Authors: Abdullah Rawan , Badralexi Irina , Halanay Andrei
Published: January 2024

We present a mathematical model that captures the dynamics of the immune system during allergic reactions. Using delay differential equations, we depict the evolution of T cells, APCs, and IL6, considering cell migration between various body compartments. The biological discussions and interpretations within the article revolve around drug desensitization, highlighting one potential application of the model. We conduct stability analysis on certain equilibrium points, demonstrating stability in some cases and only partial stability in others. Numerical simulations validate the theoretical findings.
Skull Base Tumors: Therapeutic Challenges and Multi-Disciplinary Care
Authors: Choby Garret
Published: January 2024

This special edition of Cancers, focusing on skull base tumors, highlights the unique pathologies affecting this anatomic location, as well as the multidisciplinary care necessary to treat these tumors [...]
The Role of Shared Resilience in Building Employment Pathways with People with a Disability
Authors: Campbell Perri , Wilson Erin , Howie Luke John , Joyce Andrew , Crosbie Jenny , Eversole Robyn
Published: January 2024

For workers living with a disability, pathways to sustainable employment in the open labour market are inhibited by barriers operating at different structural and societal levels. The culture of Australia’s government employment services has applied a ‘work-first’ approach that emphasises finding people employment rather than supporting the acquisition of skills and education. The net effect of this approach is the preferencing of short-term employment solutions, with a focus on individual behaviour or so-called resilience and an emphasis on personal responsibility instead of addressing structural issues. In this paper, we explore how people with disability can be supported in finding employment through a shared resilience approach offered by a Work Integration Social Enterprise (WISE). We suggest that WISEs can provide the conditions for shared resilience by developing and sustaining networks needed to generate hybrid pathways to work and by role modelling inclusive work conditions in the open labour market.
Fluid Dynamic Assessment and Development of Nusselt Correlations for Fischer Koch S Structures
Authors: Knödler Philipp , Dreissigacker Volker
Published: January 2024

Lattice structures such as triply periodic minimal surface (TPMS) structures have gained significance due to advancements in additive manufacturing, particularly 3D printing, which enable their engineering to be tailored to specific applications, such as heat exchangers. While traditional heat exchanger designs have been extensively studied, investigations into the thermal performance of TPMS structures are limited. Considering the extensive range of the geometric design variations in TPMS structures, highly efficient structures on par with the performance of conventional heat exchanger designs can be expected. This study aims to comprehensively evaluate the thermal and flow characteristics of a specific TPMS structure (Fischer Koch S), and, in particular, the impact of various volume fractions on its heat transfer performance and on its friction factor. Another key objective of this study is to develop Nusselt and friction factor correlations as a function of the investigated volume fractions for potential use in future design tools. To this end, a broad CFD study was carried out. Additionally, this study provides insights into the procedures involved in generating Fischer Koch S geometries and the modeling methodology employed in CFD investigations. Based on the results of the CFD study, the thermal and fluid dynamic performances of Fischer Koch unit cells were evaluated, resulting in heat transfer coefficients up to 160 W/m2K for the investigated structures. A comparison between the heat transfer coefficient of the examined TPMS structure and a conventional plate heat exchanger suggested a potential increase in the heat transfer coefficient of approximately 35%. The generated CFD data were subsequently utilized to formulate fitting correlations for the Nusselt number and friction factors as a function of the volume fraction. The fitted parameters of these correlations are provided in this work.
Behavior Mapping and Its Application in Smart Social Spaces
Authors: Bishop Kate , Marshall Nancy , Rahmat Homa , Thompson Susan , Steinmetz-Weiss Christine , Corkery Linda , Tietz Christian , Park Miles
Published: January 2024

Behavior mapping is the systematic observation of people using their environments. The Smart Social Spaces research project, recently completed in Sydney, Australia, is used as a vehicle to illustrate the usefulness of this method for understanding the relationships between people and public spaces in cities. Behavior mapping was the central method used to establish what impact the inclusion of smart technology and street furniture had on people’s use of two public spaces. Using this method, it is possible to record real-time patterns of people’s use of public space, enabling local authorities to better support the social use of public space and the management of its infrastructure.
Optimum Path Planning Using Dragonfly-Fuzzy Hybrid Controller for Autonomous Vehicle
Authors: Patel Brijesh , Dubey Varsha , Barde Snehlata , Sharma Nidhi
Published: January 2024

Navigation poses a significant challenge for autonomous vehicles, prompting the exploration of various bio-inspired artificial intelligence techniques to address issues related to path generation, obstacle avoidance, and optimal path planning. Numerous studies have delved into bio-inspired approaches to navigate and overcome obstacles. In this paper, we introduce the dragonfly algorithm (DA), a novel bio-inspired meta-heuristic optimization technique to autonomously set goals, detect obstacles, and minimize human intervention. To enhance efficacy in unstructured environments, we propose and analyze the dragonfly–fuzzy hybrid algorithm, leveraging the strengths of both approaches. This hybrid controller amalgamates diverse features from different methods into a unified framework, offering a multifaceted solution. Through a comparative analysis of simulation and experimental results under varied environmental conditions, the hybrid dragonfly–fuzzy controller demonstrates superior performance in terms of time and path optimization compared to individual algorithms and traditional controllers. This research aims to contribute to the advancement of autonomous vehicle navigation through the innovative integration of bio-inspired meta-heuristic optimization techniques.
The Effects of Replacing Sand with Glass Fiber-Reinforced Polymer (GFRP) Waste on the Mechanical Properties of Cement Mortars
Authors: El Bitouri Youssef , Fofana Bouagui , Léger Romain , Perrin Didier , Ienny Patrick
Published: January 2024

The aim of this study is to examine the effect of the partial replacement of sand by Glass Fiber-Reinforced Polymer (GFRP) waste on the mechanical properties of cement mortars. Compressive and flexural tests were carried out on mortars containing 0, 3, 5, 10, and 15% (by volume) of GFRP waste. It appears that the incorporation of 3% GFRP waste did not significantly affect the mechanical strength. However, further increasing the GFRP waste content led to a reduction in the mechanical strength. The flexural strength seemed less affected than the compressive strength, since the decrease in flexural strength at a 10% replacement was only 37%, while it was 54% for the compressive strength. However, an improvement in the toughness of the mortar with an increase in the substitution rate was observed. The reference sample displayed a flexural toughness of 0.351 N·m, while the mortar incorporating 15% of GFRP exhibited a flexural toughness of 0.642 N·m. The reuse of GFRP waste in cementitious materials, therefore, constitutes an interesting recycling solution.
Numerical Study of the Effect of Primary Nozzle Geometry on Supersonic Gas-Solid Jet of Bypass Injected Dry Powder Fire Extinguishing Device
Authors: Zhang Lite , Feng Yang , Wu Sifan , Jia Huixia
Published: January 2024

A two-way coupled model between polydisperse particle phases with compressible gases and a density-based coupling implicit solution method, combining the third-order MUSCL with QUICK spatial discretization scheme and the second-order temporal discretization scheme, are constructed based on the discrete-phase model (DPM) and the stochastic wander model (DRWM) in the Eulerian–Lagrangian framework in conjunction with a unitary particulate source (PSIC) approach and the SST k-ω turbulence model. The accuracy of the numerical prediction method is verified using previous supersonic nozzle gas-solid two-phase flow experiments. Numerical simulation of a two-phase jet of dry powder extinguishing agent gas with pilot-type supersonic nozzle was performed to analyze the influence of geometrical parameters, such as the length ratio rL and the area ratio rA of the main nozzle on the two-phase flow field, as well as on the jet performance indexes, such as the particle mean velocity vp,a, velocity inhomogeneity Φvp, particle dispersion Ψp, particle mean acceleration ap,a, etc. By analyzing the parameters, we indicate the requirements for the combination of jet performance metrics for different flame types such as penetrating, spreading, and dispersing.
Fracture Network Influence on Rock Damage and Gas Transport following an Underground Explosion
Authors: Stansberry Aidan , Sweeney Matthew R. , Hyman Jeffrey D. , Strait Justin , Lei Zhou , Viswanathan Hari S. , Stauffer Philip H.
Published: January 2024

Simulations of rock damage and gas transport following underground explosions that omit preexisting fracture networks in the subsurface cannot fully characterize the influence of geo-structural variability on gas transport. Previous studies do not consider the impact that fracture network structure and variability have on gas seepage. In this study, we develop a sequentially coupled, axi-symmetric model to look at the damage pattern and resulting gas breakthrough curves following an underground explosion given different fracture network realizations. We simulate 0.327 and 0.164 kT chemical explosives with burial depths of 100 m for 90 stochastically generated fracture networks. Gases quickly reach the surface in 30% of the higher yield simulations and 5% of the lower yield simulations. The fast breakthrough can be attributed to the formation of connected pathways between fractures to the surface. The formation of a connected damage pathway to the surface is not clearly correlated with the fracture intensity (P32) in our simulations. Breakthrough curves with slower transport are highly variable depending on the fracture network sample. The variability in the breakthrough behavior indicates that ignoring the influence of fracture networks on rock damage, which strongly influences the hydraulic properties following an underground explosion, will likely lead to a large underestimation of the uncertainty in the gas transport to the surface. This work highlights the need for incorporation of fracture networks into models for accurately predicting gas seepage following underground explosions.
The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease
Authors: Liu Shih-Feng , Li Chin-Ling , Lee Hui-Ching , Chang Hui-Chuan , Liu Jui-Fang , Kuo Ho-Chang
Published: January 2024

Background and Objectives: Recent studies suggest that hydrogen gas possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to explore the therapeutic potential of hydrogen gas and assess its safety and tolerability in individuals with chronic obstructive pulmonary disease (COPD). Materials and Methods: Enrolled COPD patients received standard treatments along with additional hydrogen inhalation for 30 min in the morning, afternoon, and evening over a 30-day period. The assessment included changes in the COPD Assessment Test (CAT), the modified Medical Research Council (mMRC) Dyspnea Scale, lung function, sleep quality, inflammation markers, and oxidative stress markers before and after hydrogen inhalation. Results: Six patients participated in this study. Patients 2, 3, 4, 5, and 6 demonstrated improvements in CAT scores following hydrogen gas intervention, with patients 2, 4, 5, and 6 also showing improvements in mMRC scores. Statistically, this study revealed significant improvements in CAT [15.5 (10.5–19.75) vs. 8.5 (3–13.5); p = 0.043] and mMRC scores [2.5 (1–4) vs. 2 (0–3.25); p = 0.046] before and after intervention, respectively. However, no significant differences were observed in lung function, DLCO, sleep quality, and 6 MWT before and after hydrogen therapy. CBC examination showed a significant difference in platelet count before and after treatment [247 (209.75–298.75) vs. 260 (232.75–314.5); p = 0.043], respectively, while other blood tests, inflammation markers, and oxidative stress markers did not exhibit significant differences before and after hydrogen therapy. All patients experienced no obvious side-effects. Conclusions: Adjuvant therapy with hydrogen gas demonstrated symptom improvements in specific COPD patients, and no significant adverse effects were observed in any of the patients. Hydrogen gas may also exert a modulatory effect on platelet count.
The Normal Casimir Force for Lateral Moving Planes with Isotropic Conductivities
Authors: Khusnutdinov Nail , Emelianova Natalia
Published: January 2024

We consider the two planes at zero temperature with isotropic conductivity that are in relative lateral motion with velocity v and interplane distance a. Two models of conductivity are taken into account—the constant and frequency-dependent Drude models. The normal (perpendicular to planes) Casimir force is analyzed in detail for two systems—(i) two planes with identical conductivity and (ii) one plane that is a perfect metal. The velocity correction to the Casimir energy, ΔvE∝v2, for small enough velocities is used for all considered cases. In the case of constant conductivity, η, the energy correction is ΔvE∝η/a3v/η2 for v≪η≪1.
A Différant Kind of Preaching: Derrida and the Deconstruction of Contemporary Homiletics
Authors: Myers Jacob D.
Published: January 2024

Homiletics manifests as a technē that commends certain kinds of preaching over others. As such, homiletics structures debate unaware of the philosophical assumptions operative within it. This paper challenges the logocentrism of contemporary homiletical theories in light of Jacques Derrida’s deconstructive analytic. I take as my privileged conversation partner Fred Craddock, the much-lauded king of the New Homiletic. I argue that in commending inductive over deductive logic, Craddock merely inverts the logical movement of preaching, thereby reinscribing logocentrism. Utilizing Derrida’s neologism différance, I press homiletics toward what I am labeling conductive preaching, which reframes homiletical theory beyond the epistemological biases that condition it.
Evolving Paradigms of Recombinant Protein Production in Pharmaceutical Industry: A Rigorous Review
Authors: Jayakrishnan Achuth , Wan Rosli Wan Rosalina , Tahir Ahmad Rashidi Mohd , Razak Fashli Syafiq Abd , Kee Phei Er , Ng Hui Suan , Chew Yik-Ling , Lee Siew-Keah , Ramasamy Mahenthiran , Tan Ching Siang , Liew Kai Bin
Published: January 2024

Many beneficial proteins have limited natural availability, which often restricts their supply and thereby reduces their potential for therapeutic or industrial usage. The advent of recombinant DNA (rDNA) technology enables the utilization of different microbes as surrogate hosts to facilitate the production of these proteins. This microbial technology continues to evolve and integrate with modern innovations to develop more effective approaches for increasing the production of recombinant biopharmaceuticals. These strategies encompass fermentation technology, metabolic engineering, the deployment of strong promoters, novel vector elements such as inducers and enhancers, protein tags, secretion signals, synthetic biology, high-throughput devices for cloning, and process screening. This appraisal commences with a general overview regarding the manufacture of recombinant proteins by microbes and the production of biopharmaceuticals, their trends towards the development of biopharmaceuticals, and then discusses the approaches adopted for accomplishing this. The design of the upstream process, which also involves host selection, vector design, and promoter design, is a crucial component of production strategies. On the other hand, the downstream process focuses on extraction and purification techniques. Additionally, the review covers the most modern tools and resources, methods for overcoming low expression, the cost of producing biopharmaceuticals in microbes, and readily available recombinant protein products.
Modelling the Purchase of Green Packaged Products: The Significant Impact of the West–East Cultural Context
Authors: Bravo Alencar , Vieira Darli
Published: January 2024

Although a relatively recent phenomenon, green packaging has been the focus of extensive research aimed at understanding consumer perceptions of green packaging and consumer behaviours toward green packaging. The effectiveness of these inquiries, however, has varied. The current study has determined that the theory of planned behaviour (TPB) has had the highest level of effectiveness and promotion of scientific progress in this field. This study contributes to the research by combining diverse research endeavours regarding environmentally sustainable packaging. The methodology used initially produced only moderately sufficient fitting indicators. Nonetheless, the literature suggests that there are significant differences in consumer behaviours between Western and Eastern cultural contexts. The importance of cultural sensitivity and cross-cultural understanding in a global economy is highlighted by the disparities among consumers. By recognizing and valuing these diversities, companies can successfully encourage the adoption of eco-friendly packaging through the adoption of policies that take into account the cultural context.
Los hábitos saludables como estrategia para mejorar una cultura ambiental en estudiantes
Authors: Heiner Cabrera Olegario , Moreno Muro Juan Pablo
Published: January 2024

Los hábitos saludables son importantes para la mejora de una cultura ambiental para los estudiantes de las instituciones educativa y de su población en conjunto. Es por ello, que es necesario analizar la importancia de los hábitos saludables como estrategia para la mejora de una cultura ambiental en estudiantes. Para ello, se llevó cabo una revisión bibliográfica de literatura científica en bases de datos como Web of Science, SciELO, Redalyc, Scopus y páginas web oficiales, empleando como palabras de búsqueda: Hábitos saludables, cultura ambiental, educación ambiental, conciencia ambiental y medioambiente, posteriormente se establecieron dos categorías para analizar como los hábitos saludables como estrategia pedagógica, y la Cultura ambiental. Concluyendo que los hábitos saludables son de gran importancia para generar cambios de actitudinales con el medioambiente ya que proporcionan en los estudiantes una cultura ambiental en un marco de respeto y valores.
Evaluación formativa en la educación
Authors: Santiago Paucar Margot Nelida , Villafuerte Álvarez Carlos Alberto
Published: January 2024

Este estudio se enfoca en analizar la aplicación de la evaluación formativa en la educación, destacando su papel fundamental en adaptar la instrucción a los procesos de aprendizaje. La revisión sistemática, realizada según las pautas PRISMA entre 2017 y 2022, consideró bases de datos como Scielo, Dialnet, EBSCO, Google Scholar, Scopus, Redalyc.Org, y ProQuest. De las 24 fuentes seleccionadas tras criterios de inclusión y exclusión, se concluye que las actividades grupales y los focus group son estilos apropiados para fomentar el pensamiento crítico y reflexivo en los estudiantes. Se destaca la importancia de informar sobre las ventajas de estas prácticas, subrayando la necesidad de la participación activa de cada estudiante.
Didactic potential of MOOCs in teaching Russian as a foreign language
Authors: Dinevich Irina A. , Ivanova Anna S. , Kunovski Marina N.
Published: January 2024

The article is devoted to the description of mass open online courses «Read. Listen. Speak» and «Verbs of motion in Russian language», intended for foreign students at the pre-university stage of training. The article presents an analysis of the lexical and grammatical content of presentation and video materials of the proposed training courses, presents a system of tasks from basic to advanced levels, and also offers practical recommendations on the use of various methodological techniques in teaching Russian as a foreign language to foreign students. The authors analyzed the forms of organization of the activities of all subjects of the distance learning process, revealed the didactic potential of mass open online courses as promising distance technologies in teaching Russian as a foreign language.
Youth religious education: from the ideas of reformist pedagogy to modern times
Authors: Karamanov Oleksiy , Prokip Andrii , Tsiupryk Andrii , Ivashchenko Kateryna , Koliada Tetiana , Dobryden Alla
Published: January 2024

The purpose of the study is to investigate the state of youth religious education, taking into account the mutual influence of educational and religious ideas in Galicia in the context of Reformed pedagogy of the turn of the 20th century. To achieve the goal, three scientific tasks were solved, in particular: to study the main factors of dissemination and interpretation of the ideas of Reformed pedagogy in Galicia; to identify fundamental aspects of the interaction of educational and religious ideas; to consider the nature of postulates of religious or Christian pedagogy; to study the opinion of student youth regarding their religious beliefs and influence on worldview (225 students of various higher education institutions of Ukraine aged from 19 to 22 participated in the survey). Based on the analysis of the impact of the ideas of reformative pedagogy illustrated by Galicia of the early 20th century, the system of religious education from the points of view of Ukrainian and Polish pedagogues as well as religious figures is discussed. Religious education is emphasized to be a powerful means of developing moral values of the individual, and a significant factor of their social behavior. Facts of interaction of educational and religious ideas in the context of reformative pedagogy in the theory and educational practice of Galicia are stated.
The concept of the pilot project for the dual format of training specialists: directorial education
Authors: Shumakova Svitlana , Gordeev Sergey , Nabokov Roman , Buhaiova Viktoriia , Borysova Alina
Published: January 2024

Considering global educational trends and strategies, the specialists of the Department of Directing at Kharkiv State Academy of Culture (KhSAC) are inspired by the experimental implementation of a dual-format professional training program in the field of Performing Arts (speciality 026). Such a precedent has not previously existed in directorial education in Ukraine. The introduction of the first educationalprofessional program in Ukraine, “Directing for Show and Art Projects”, in 2023 is an innovative strategy for preparing professionals initiated by the Department of Directing at KhSAC, which can be considered the foundation for research and analysis of the possibility for implementing a pilot project for practice-oriented directorial education. The research methodology is based on studentcentered and competency-based approaches, principles of pedagogy concerning the determinism of theory and practice in the educational process, all directed within a systemic approach. The conceptualization of the pilot project involves a dual form of education alongside the analysis of the standardization principles in training that envisages achievement of a new level of professional competence for competitive specialists. Methodological approaches and pedagogical modeling have been reproduced with the purpose of further development of educational standards and competency requirements that align with the descriptors of the National Qualifications Framework.
The impact of blended learning on undergraduate english language learners: a case study at Ha'il University, Saudi Arabia
Authors: Alkhannani Badriah
Published: January 2024

In current times, blended learning has emerged as one of the most noteworthy trends in the educational sector. Blended learning approach is a group of various learning approaches and elements that may be integrated to assist learners in fulfilling their instructional goals more efficaciously than learning in traditional learning environments and combines the best aspects of online and instructor-led learning and is delivered in a ‘small-group’ or ‘one- on-one’ format. The present study was designed to explore, how blended learning may be utilized in an effective manner for developing the English language expertise of undergrad students at the University of Ha’il, Saudi Arabia. Blended learning by incorporating adaptive learning platforms that tailor content based on individual student achievements. The outcomes report that the blended learning approach can be exploited for enhancing the environment of English learning for motivating the students toward the learning English language. The study at Ha'il University concluded that the integration of technology provides access to diverse digital resources, such as online lectures and interactive simulations, enhancing the overall educational experience. Thus, the teaching English at the undergraduate level through a mixed learning approach will be sufficient to support all facets of learning and teaching.
Historical evolution of legislative regulation of the media in the west
Authors: Lebedeva Simona Ernestovna , Vakku Grigory Vladislavovich , Solovey Larisa Boleslavovna , Goncharov Dmitry Konstantinovich
Published: January 2024

The objective of this study is to analyze the legal regulation of the media in Western countries. The study is based on universal scientific methods, such as observation, deduction, analysis, comparative and historical historical analysis of different legislatures and the practices of their implementation. The countries chosen for the analysis are the so-called "old Europe" countries. The study concludes that the legal regulation of the media is a complex issue that must be addressed with a holistic approach. The law is important, but it is not enough to guarantee freedom of expression and information pluralism. There is also a need for effective law enforcement and media monitoring systems.
Modern trends of physical education and sports in the education system of Ukraine
Authors: Babalich Viktoriya , Sobko Nataliya , Maleniuk Tetiana , Sobko Serhiy , Kovalova Yuliia
Published: January 2024

The article examines issues of modern trends in physical education and sports in the education system of Ukraine. The role of video materials in the innovative provision of the educational and training process is shown, which became possible for use with the appearance of special programs for processing digital video information, and digital video cameras that allow the output of video information on various media. In the educational process of training future specialists in physical culture and sports, the following options for innovation policy are defined: the policy of "innovative push", "market orientation", "social orientation", and "direction for change". The multifaceted nature of innovative educational innovations is shown. For high-quality professional training of future specialists in physical culture and sports, a methodological basis is described to use innovative types of motor activity. The conducted experimental research makes it possible to conclude positive qualitative changes in the formation of the readiness of future physical culture and sports specialists to use innovative educational technologies in educational and professional activities, which indicates the effectiveness of the proposed method of applying innovative educational technologies in institutions of higher education to form future specialists of multimedia competence.
APLIKASI PENGENALAN BODY PARTS BERBASIS AUGMENTED REALITY (AR) MENGGUNAKAN ANDROID
Authors: Herlisa Helda , Yuliyanti Wan
Published: January 2024

Meningkatnya penggunaan teknologi dalam dunia pendidikan menyebabkan meningkat pula motivasi para pendidik dalam mengembangkan media pembelajaran menggunakan smartphone atau biasa dikenal dengan e-learning berbasis android. Salah satunya adalah dengan menggunakan aplikasi augmented reality (AR) bagi anak usia 4-6 tahun yang kaya akan aspek interaktif, menyenangkan, menantang, memotivasi dan memberi ruang kepada murid untuk lebih meningkatkan keingintahuan mereka. Tujuan dari dirancangnya media pembelajaran kosakata (vocabulary) Bahasa Inggris untuk tema pengenalan body parts dengan mengimplementasikan aplikasi AR yaitu dapat digunakan untuk menciptakan sebuah lingkungan pembelajaran yang lebih interaktif dimana anak dapat berinteraksi langsung dengan obyek dunia maya sehingga anak-anak dapat bermain sambil belajar. Hal ini dilakukan dengan cara menggambar objek 3D pada marker, yakni sebuah pola yang bersifat unik dan dapat dikenali oleh aplikasi. Smartphone memungkinkan pengembangan aplikasi AR dengan murah serta dapat diakses oleh banyak pengguna. Aplikasi ini dibuat dengan vuforia SDK sebagai alat untuk mengembangkan AR dengan java, C# berbasis android. Penggunaan teknologi AR diharapkan bisa menampilkan objek berupa upper body, middle body, dan lower body, secara virtual 3D dalam sebuah marker sebagai alat peraga yang dituangkan dalam sebuah handbook. Marker yang dideteksi oleh kamera akan menampilkan model 3D di layar perangkat android secara real time dan mengeluarkan suara ketika objek di klik. Aplikasi ini dibangun dengan menggunakan suatu metode dengan menganalisa problem, approach, development, implementation dan result. Melalui aplikasi pengenalan body parts berbasis AR menggunakan android khusus untuk anak usia 4-6 tahun atau yang sedang duduk di bangku PAUD ini dapat meningkatkan minat dan kemampuan anak dalam belajar vocabulary.
Neolithic Complex Hunter-Gatherers in Korea Revisitied
Authors:   The Korean Neolithic Society, Seong Chuntaek
Published: January 2024

The present essay critically reviews the recent attempt to conceptualize the Neolithic society in Korea as complex hunter-gatherers. While large scale settlements with 20 to 30, and even 60 subterranean houses are well recognized in the Neolithic Korea, many archaeologists still consider that the occupants were mainly hunters and gatherers. The concept of complex hunter-gatherers were originally proposed to denote large village societies with prominent social hierarchies relying on abundant marine resources, and some archaeologists extended its use to prehistory. Aside from the archaeological applicability of the concept itself, the Korean Neolithic archaeological record lacks critical elements of the complex hunter-gatherers. While the discussion and application of the concept in the context of Korean Neolithic have opened the new theoretical landscape, it is true that many burials and associated goods, let alone habitations sites, do not suggest the development of social hierarchies. The characteristics of burial goods are consistent with sexual differences which is widely observable with most hunter-gatherers societies. Furthermore, many Korean Neolithic sites yielded evidence of broomcorn and foxtail millet domestication, which most archaeologists try to explain in the context of complementary subsistence activities still dominated by hunting and gathering. The existence of material evidence of plant domestication strongly suggests that the Neolithic people were not ‘typical’ hunter-gatherers, which begs further discussions of the role of domestication in the Neolithic and its implications to the development of settled village lives. While the concept of the complex hunter-gatherers was coined to embrace cases that do not fit into the traditional hunter-gatherer society, it has become another stereotype that does not allow wide range of variability in prehistoric societies. Rather, we need to pay more attention to the role of mixed economy or horticulture and dynamics of orderly egalitarian societies in the Neolithic Korea.
Novel Development of Pasta Enriched with Spirulina platensis Microalgae: Biochemical and Histological Parameters
Authors: El-Sharnouby Gamal , Abughoush Mahmoud , Choudhury Imranul
Published: January 2024

The present study aims to determine the effect of bioactive compounds (total phenolic, total flavonoids, and antioxidant activity) of Spirulina platensis powder and its pasta products on kidney and liver diseases in rats. Pasta preparation enriched in spirulina powder with a standard treatment formulation. Pasta was supplemented by adding Spirulina platensis powder at different levels (5, 10, 15, and 20 %).  The results indicated that rats treated with spirulina had lower plasma levels of ALT, AST, ALP, Albumin, creatinine, and total bilirubin after the end of the experiments. However, liver glutathione (GSH) concentration was markedly decreased as compared to the control group. In conclusion, pasta enriched with spirulina improved liver and kidney functions and enhanced oxidative stress indices. Additional studies are necessary to test the application of Spirulina platensis in other contexts.