bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Antibiotic-Impregnated Spacers on Bone Healing in an Animal Model of the Induced Membrane Technique
Authors: Sun Hening , Godbout Charles , Ryan Gareth , Ali Ikran , Higgins James , Hoit Graeme , Hall Jeremy , Halai Mansur , Khoshbin Amir , Schemitsch Emil H. , Nauth Aaron
Published: February 2025

Background:

Surgeons performing the induced membrane technique (IMT) often incorporate antibiotics into the spacer at the first stage of the surgical procedure to prevent or treat infection. However, the effect of antibiotic use on subsequent bone healing is not clear. This study aimed to investigate if antibiotic-impregnated spacers impact subsequent bone healing in a rat model of the IMT.

Methods:

Inbred male rats (Fischer 344) were randomly divided into 3 groups according to the antibiotic dose in the spacer: (1) control (no antibiotics), (2) low-dose (1.2 g tobramycin and 1.0 g vancomycin per 40 g of polymethylmethacrylate [PMMA]), and (3) high-dose (3.6 g tobramycin and 3.0 g vancomycin per 40 g of PMMA). We created a 5-mm segmental defect in the right femoral diaphysis. The bone was stabilized with a plate and screws, and the assigned spacer was inserted into the defect. Four weeks later, the spacer was removed and bone graft was placed within the defect. Radiographs made 12 weeks after grafting were scored according to union status and degree of bone healing. Micro-computed tomographic (CT) analysis and biomechanical testing were also performed at 12 weeks.

Results:

Full radiographic union was achieved in 10 (83%) of 12 control animals, 13 (100%) of 13 low-dose animals, and 8 (62%) of 13 high-dose animals (high-dose compared with low-dose: risk ratio, 11.0; p = 0.039). The control group demonstrated higher bone volume compared with the high-dose group (mean difference, 9.0 mm3; p = 0.039), and there was a trend toward higher bone volume in the low-dose group compared with the high-dose group (mean difference, 8.1 mm3; p = 0.06). The biomechanical results demonstrated that maximum stiffness was significantly higher in the low-dose group compared with the high-dose group (mean difference, 14.1 N*mm/degree; p = 0.009).

Conclusions:

Our results demonstrated that low doses of antibiotics in PMMA spacers used for the IMT did not impair bone healing. However, high doses of antibiotics demonstrated inferior bone healing.

Clinical Relevance:

The addition of high-dose antibiotics to the PMMA spacers used for the IMT may result in impaired bone healing and should be used with caution.
The effectiveness of miRNAs as potential non-invasive liquid biomarkers for the diagnosis and prognosis of prostate cancer: A systematic review
Authors: Lopreiato Gianfranco
Published: February 2025

Background: Prostate cancer (PCa) is one of the most prominent cancers worldwide. However, many limitations in its diagnostic and prognostic protocols lead to severe unreliability. This research aims to evaluate the current literature to better understand the effectiveness of miRNAs as potential diagnostic and prognostic non-invasive liquid biomarkers of prostate cancer.
Methods: A systematic review was conducted by thorough searches on the Omni and PubMed database for articles in the past five year, that met specific eligibility criteria. Characteristics of the 18 chosen studies varied, as the goal was to include diverse populations and methodologies to encompass all the current literature. Key differentially expressed miRNAs were extracted from the research, including their dysregulation signatures and associated statistical values.
Results: MiRNA panels, in conjunction with current diagnostic protocols and clinicopathological factors, display the most promise as a future diagnostic tool for PCa. More specifically, a 2-miRNA and 5-cs-miRPs panel show remarkable potential for future use in prostate cancer screening and diagnosis. Some limitations of the supporting evidence include heterogeneity between studies’ methodology and analysis, lack of standardization in the current protocols of miRNA collection and quantification, and the influence of genetic and environmental factors on the expression of these biomarkers.
Conclusion: Future research should validate which miRNAs to include in a panel, how to standardize their storage, collection, and quantification, and how to incorporate them into the current protocols. Clinical applications of miRNAs as non-invasive liquid biomarkers can contribute to early cancer detection and prevention, thus improving outcomes for prostate cancer patients.
Estimación de la población canina con dueño y sus características generales en el distrito de Lince, Lima – Perú, 2023
Authors:   , Avila Bailon Cecilia del Rosario
Published: February 2025

El presente estudio tuvo como propósito estimar la población canina con dueño y sus características generales en el Distrito de Lince, Lima-Perú, durante el año 2023. Se empleo una metodología basada en encuestas que abarcó diversas variables como: tenencia de canes, número de mascotas, raza, sexo, edad, por tipo vivienda, tipo de alimentación, tamaño, utilidad del can, la frecuencia de atención veterinaria, vacunación antirrábica, así como el conocimiento del propietario sobre enfermedades zoonóticas. En el presente estudio se aplicó encuestas a 700 viviendas, seleccionadas por muestreo aleatorio estratificado por zonas y manzanas, en el distrito de Lince. Los resultados indicaron una relación persona: can de 5.58:1 y el promedio de canes por vivienda fue de 0.65. La población canina estimada fue de 9805. Como características más resaltantes de los canes del distrito se encontró que 58.81% ± 4.53 eran de raza pura y 55.73% ± 4.57 de los canes eran machos. Así mismo, la edad promedio de los canes fue de 55.19 ± 3.01 meses. En cuanto a la vacunación, el 87% ± 3.09 de los canes ha sido vacunado contra la Rabia; de los cuales, 65.86%± 4.36 recibió la vacunación en clínicas veterinarias particulares. En el estudio se obtuvieron 16 resultados adicionales que resultan de particular relevancia para el diseño de intervenciones sanitarias a futuro, de impacto en salud pública, orientados a promover una tenencia responsable de mascotas en el distrito de Lince. Además, servirán como base para la implementación de campañas sanitarias por parte del Ministerio de Salud y de la Municipalidad del distrito.
Previniendo las rickettsiosis en México: importancia del material de promoción de la salud
Authors: Caamal-Itza Abdiel Ismael , Santos Carlos Alberto , Ramón-García Luis Emilio , Gutiérrez-Cedillo Verónica , Danis-Lozano Rogelio , Puerto-Manzano Fernando Isaías , Dzul-Rosado Karla Rossanet
Published: February 2025

Las rickettsiosis, enfermedades transmitidas por garrapatas, pulgas y piojos, representan un problema de salud pública en México, especialmente en contextos de pobreza y baja alfabetización. A pesar del aumento en las estrategias de prevención, los casos se incrementaron entre 2021 y 2023, principalmente en el norte del país. El predominio de materiales de promoción de la salud únicamente en español, con exceso de texto y distribuidos principalmente en redes sociales, limita su accesibilidad en las poblaciones de mayor riesgo. Estrategias como campañas y materiales bilingües, adaptadas a las necesidades específicas de la población objetivo, han demostrado ser efectivas para superar estas barreras, aunque su implementación sigue siendo escasa. Es fundamental capacitar al personal médico mediante guías actualizadas que reduzcan el subdiagnóstico y aborden amenazas epidemiológicas emergentes. Asimismo, una colaboración intersectorial y la adopción del enfoque “Una sola salud” son esenciales para enfrentar esta problemática integralmente. Este ensayo compila y analiza los materiales de promoción de la salud sobre rickettsiosis elaborados en México por diversas instituciones académicas y gubernamentales, para identificar áreas de oportunidad.
First Evidence of Coexistence of Pseudo Pelger-Huët Anomaly and Balanced Translocation in a two decades retrospectively exposed human subject
Authors: Chaurasia Rajesh Kumar , Pathak Ranjana S. , Goel Anjana , Shirsath Kapil B. , Bhat Nagesh N. , Khan Arshad , Sapra Balvinder K.
Published: February 2025

This study investigated the long-term stability of cytogenetic and morphological markers, including dicentric chromosomes (DC), unbalanced translocation (UT), balanced translocation (BT), and Pseudo Pelger-Huët Anomaly (PHA), in a radiation worker exposed to an acute dose of 60Co-γ radiation. Initial dose assessment, immediately after exposure via thermoluminescent dosimeters (TLDs) and DC, yielded a physical dose of 438.8 mGy and a biological dose of 398 mGy respectively. A follow-up biodosimetry evaluation, conducted 24 years postexposure, yielded a dose estimate of 449 mGy on the basis of BT, closely matching the initial TLD measurement (+2.3% relative error). In contrast, the DC, UT, and micronuclei (MN) frequencies fell within the background range, confirming their instability over time. We also assessed the presence of PHA in blood smears from the same volunteer. PHA, a morphological marker of neutrophils originating exclusively in vivo from bone marrow progenitor cells, demonstrated a more than twofold increase in frequency compared to background levels, suggesting an association with radiation exposure. This is the first report of concurrent BT and PHA persistence in the same individual, demonstrating the stability of these biomarkers for retrospective dose estimation. BT offered reliable dose reconstruction decades after exposure. We could not translate the PHA yield into an absorbed dose, as no in-house dose‒response curve was established.
Probing valley phenomena with gate-defined valley splitters
Authors: Torres Luna Juan Daniel , Vilkelis Kostas , Manesco Antonio L. R.
Published: February 2025

Despite many reports of valley-related phenomena in graphene and its multilayers, current transport experiments cannot probe valley phenomena without the application of external fields. Here we propose a gate-defined valley splitter as a direct transport probe for valley phenomenon in graphene multilayers. First, we show how the device works, its magnetotransport response, and its robustness against fabrication errors. Secondly, we present two applications for valley splitters: (i) resonant tunneling of quantum dots probed by a valley splitter shows the valley polarization of dot levels; (ii) a combination of two valley splitters resolves the nature of order parameters in mesoscopic samples.
Characterization of enteric pathogens in Harare, Zimbabwe using environmental surveillance and metagenomics
Authors: Cheung Samantha , Zhou Nicolette A. , Ruhanya Vurayai , Jesser Kelsey , Nezomba Ignitious , Musvibe John , Manyisa Brendon , Nyandoro George , Chibukira Paradzai , Mukaratirwa Arnold , Muserere Simon Takawira , Masunda Kudzai , Ong Angelo , Meschke John Scott
Published: February 2025

High diarrheal disease burden remains an urgent concern in low- and middle-income countries, greatly affecting children under the age of 5 years and those living with HIV and AIDS. Treatment of infectious diseases has also become increasingly difficult with the rapid rise of antimicrobial resistance (AMR). Environmental surveillance of wastewater can supplement gaps in clinical surveillance as residents on a sewage system contribute to the wastewater, providing simple, composite samples that can improve understanding about both pathogens and AMR in the community. This study evaluated the effectiveness of environmental surveillance with shotgun metagenomics as a tool to characterize a broad range of enteric pathogens, antibiotic resistance genes, and virulence factor genes (VFGs) in wastewater from six neighborhoods in Harare, Zimbabwe. Alpha and beta diversity of the microbial community were similar between high-income and low-income suburbs. Enteric pathogens of high AMR and clinical concern, including Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella enterica, were detected in all samples. The top VFGs encoded for delivery, adherence, and motility, functions important in toxin secretion, colonization, and immune modulation. The findings provide a foundation for future studies to explore environmental surveillance and shotgun metagenomics as a public health monitoring tool for enteric diseases.
Birinci Basamak ve Evde Sağlık Hizmetlerinde Yaşlıların Pnömokok ve İnfluenza Aşılanma Oranlarının Değerlendirilmesi
Authors: Şimşek Yurt Nur , Yavuz Erdinç
Published: February 2025

Amaç: Ülkemizde yaşlıların aşılanma oranlarına odaklanan toplum tabanlı araştırmalar oldukça sınırlıdır. Bu çalışmanın hedefi, birinci basamak sağlık hizmetlerine başvuran ve evde sağlık hizmeti alan yaşlı bireylerde pnömokok ve influenza aşılanma oranlarını incelemektir.
Yöntem: Bu araştırma, 1 Temmuz 2023 ile 15 Ağustos 2023 tarihleri arasında Samsun il merkezinde evde sağlık hizmetleri kapsamında kayıtlı olan ve rastgele seçilen bir aile sağlığı merkezine başvuran 65 yaş ve üzeri bireylerle gerçekleştirildi. Katılımcıların demografik bilgileri, kronik hastalıkları, ilaç kullanımı, son bir yıl içinde influenza aşısı durumu ve pnömokok aşısı ile ilgili veriler yüz yüze görüşmeler yoluyla toplandı. Verilerin analizi SPSS 26.0 programı kullanılarak yapıldı ve p<0,05 anlamlılık düzeyi olarak kabul edildi.
Bulgular: Çalışmamıza, 210 evde sağlık hizmeti alan ve 219 birinci basamak sağlık hizmetlerine başvuran yaşlı birey katıldı. Evde sağlık hizmeti alan hastaların %4,3'ü pnömokok ve %8,1'i influenza aşısı yaptırmıştı. Birinci basamak sağlık hizmetlerine başvuranların %10,5'i pnömokok ve %16,9'u influenza aşısı olmuştu. Evde sağlık hizmeti alanların aşılama oranları, birinci basamak sağlık hizmetlerine başvuranlardan anlamlı derecede daha düşüktü (sırasıyla; p=0,014, p=0,006).Seksen beş yaş ve üzeri evde bakım hastalarında pnömokok aşısı, kronik akciğer hastalığı olanlarda influenza aşısı oranları yüksekti (sırasıyla; p=0,029, p=0,013). Birinci basamağa başvuranlarda diyabet (p=0,007) ve kronik akciğer hastalığı (p=0,002) olanların pnömokok aşısı oranları yüksekti. Polifarmasisi olan yaşlı bireylerde her iki aşının uygulanma oranı yüksek saptandı (sırasıyla; p=0,004, p<0,001).
Sonuç: Yaşlı bireylerin aşılanma oranlarının hedeflenen seviyelere ulaşmadığı belirlenmiştir. Evde sağlık hizmetine kayıtlı yaşlı bireylerde aşılanma oranları daha düşüktür. Aile hekimlerine, yaşlı bireylerin aşı durumlarını sorgulamaları ve bilgilendirmeleri önerilmektedir. Aile hekimlerinin aktif rolü, aşılama ile ilgili hedeflere ulaşmada kilit faktörlerdendir.
Prediksi Kesulitan Keuangan Dengan Menggunakan Model Altman Modifikasi Z-Score
Authors: Wahyuni Sri
Published: February 2025

Textile industry is contracted due to the Covid-19 pandemic, reduction of export, increase of import, and the spread of thrifting trend. This unfavorable condition has put losses to the issuers of textile industry. Here financial distress prediction analysis is crucial since the earlier the financial distress is detected, the more useful information received by internal parties. Such information is used by the stakeholders as a consideration in their decision-making. The objective of this research is to identify and analyze the prediction of financial distress obtained from the use of the modified Altman Z”-Score. Using purposive sampling technique, twelve companies were selected as the sample of this quantitative descriptive study. The financial distress was measured using the modified Altman Z”-Score, which incorporates four financial ratios. This study finds that seven companies (58%) are predicted to have financial distress for three years, that two companies (17%) have fluctuating financial conditions, that two companies (17%) improves their financial performance and tat one company (8%) has good financial condition for three years. The results of this research are useful for investors as a signal for the consideration of investment decision-making and for companies as an early warning and early cues for evaluation to prevent bankruptcy.
 
Abstrak
Industri tekstil terkontraksi akibat pandemi Covid-19, penurunan ekspor tekstil, peningkatan impor produk tekstil serta maraknya trend thrifting yang  mengakibatkan  emiten tekstil mengalami kerugian. Analisis prediksi kesulitan keuangan penting karena semakin dini tanda kesulitan keuangan terdeteksi, maka akan semakin baik bagi pihak internal serta dapat memberikan informasi yang berguna sebagai sinyal bagi pemangku kepentingan untuk bahan pertimbangan dalam pengambilan keputusan. Penelitian ini bertujuan untuk mengetahui dan menganalisis prediksi kesulitan keuangan dengan menggunakan model Altman Modifikasi Z”-Score. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Pemilihan sampel menggunakan teknik purposive sampling sehingga didapatkan sampel berjumlah 12 perusahaan. Kesulitan keuangan diukur dengan menggunakan model Altman Modifikasi Z"-Score yang memanfaatkan empat rasio keuangan. Hasil penelitian menunjukkan bahwa terdapat 58% atau 7 perusahaan diprediksi mengalami kesulitan keuangan selama tiga tahun, 17% atau 2 perusahaan kondisi keuangannya berfluktuasi, dan 17% atau 2 perusahaan mengalami peningkatan kinerja keuangan dan 8% atau 1 perusahaan  memiliki keuangan yang sehat selama 3 tahun. Hasil penelitian ini berguna bagi investor sebagai sinyal untuk bahan pertimbangan dalam pengambilan keputusan investasi serta bagi perusahaan sebagai tanda peringatan dini dan evaluasi untuk mencegah terjadinya kebangkrutan.
Pengaruh Kinerja Keuangan Perusahaan Terhadap Return Saham
Authors: Ramadhan Bimansyah Saktiaji , Aisjah Siti
Published: February 2025

The objective of this research is to identify the effects of company financial performance, which is proxied by Quick Ratio (QR), Debt-to-Equity Ratio (DER), and Earnings Per Share (EPS), on the stock returns of mining companies. The population is 47 mining companies listed on the Indonesia Stock Exchange that have consecutively paid their dividend during the 2016-2020 period. Using purposive sampling, ten of them were selected as the sample. The data of this research was analyzed using descriptive statistics, classical assumption test, hypothesis test (R2, F, and t tests), and multiple linear regression. The results of the analyses indicate that quick ration significantly influences stock return, that dent-to-equity ratio significantly affects stock return, return on equity significantly impacts stock return, and that earning per share significantly influences stock return. Therefore, it can be concluded that financial performance has significant effects on stock return.
 
Abstrak
Tujuan penelitian ini untuk mengetahui Pengaruh Kinerja Keuangan Perusahaan yaitu quick ratio (QR), debt to equity ratio (DER), return on equity (ROE), earning per share (EPS) terhadap return saham pada perusahaan pertambangan. Populasi penelitian ini adalah perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) yang membayarkan dividen secara terus menerus selama periode 2016-2020. Metode pengambilan sampel dalam penelitian ini menggunakan purposive sampling menghasilkan 20 sampel perusahaan dengan total keseluruhan populasi 47. Metode analisis data yang digunakan dalam penelitian ini yaitu statistik deskriptif dan menggunakan uji asumsi klasik dan uji hipotesis (uji R2, F, dan uji t) dengan metode analisis regresi linier berganda. Berdasarkan hasil analisis menunjukkan quick ratio berpengaruh signifikan terhadap return saham, debt to equity ratio berpengaruh signifikan terhadap return saham, return on equity berpengaruh signifikan terhadap return saham, earning per share berpengaruh signifikan terhadap return saham. Hasil tersebut menunjukkan bahwa kinerja keuangan perusahaan berpengaruh signifikan terhadap return saham.
Diabetes and Sarcopenia: Intersection of Co Morbid Conditions
Authors: Hoogwerf Byron J.
Published: February 2025

Sarcopenia is more common in persons with type 2 diabetes mellitus (T2DM) than in persons without diabetes. There is overlap of some pathophysiologic features of sarcopenia and T2DM. In addition, the risk for sarcopenia is associated with common complications of T2DM including renal disease, cardiovascular disease and neuropathy. Glycemic control in T2DM may have some benefits on sarcopenia. The specific effects of glucose lowering agents on sarcopenia suggest that metformin, insulin, thiazolidinediones and GLP1 receptor agonists may have favorable effects on sarcopenia while SGLT2 inhibitors may have an adverse effect. However, GLP1 RA’s and SGLT2 inhibitors have been associated with favorable effects on cardiovascular and renal outcomes and thiazolidinediones with an increased risk for heart failure. Thus glucose lowering risk/benefit ratio overall is key to selection of glucose lowering agents. Nutrition guidelines for T2DM generally align with recommendations for sarcopenia. Data on the benefits of aerobic and resistance exercise in patients with T2DM and sarcopenia is very limited, but some data suggest a benefit of resistance exercises.
Documenting the Design, Development, and Evaluation of the eCase Manager: A Proposed mHealth Solution for Linking Household Contacts to Care under Universal Tuberculosis Testing and Universal TB Preventive Treatment in South Africa (Preprint)
Authors: Mudzengi Don Lawrence , Ntshiqa Thobani , Hamada Yohhei , Ndebele Felex , Mpanza Thapelo , Kyobutungi Bridget , Williams Candice , Kennealy Meghan , Rangaka Molebogeng , Velen Kavindhran , Charalambous Salome
Published: February 2025

BACKGROUND

Documenting the development of mobile health (mHealth) tools is crucial for enabling future projects to build on existing knowledge. Effective documentation supports the refinement of design, implementation, and evaluation processes, facilitating the scale-up and adaptation of health interventions across diverse contexts.

OBJECTIVE

In this paper, we describe how we developed the eCase Manager, a WhatsApp-based chatbot designed to facilitate linkage-to-care for household contacts of TB patients by providing nudges, reminders, and personalised support. We developed the eCase Manager to address the human resource capacity challenges posed by South Africa's new universal TB testing and tuberculosis preventive treatment (TPT) policies.

METHODS

We applied a design thinking framework with seven phases—empathise, discover, define, prototype, build and launch, improve, and evaluate—to develop the eCase Manager. The process started with gathering insights from TB contact tracing studies and consulting with global and local experts to address the challenges of universal TB testing and TPT. From these findings, we defined the core functionalities of the eCase Manager and incorporated the health belief model (HBM) to encourage health-seeking behaviour. In collaboration with Reach Digital Health, we developed the WhatsApp-based chatbot, selecting WhatsApp for its wide accessibility and user-friendliness.

RESULTS

We successfully developed and launched the eCase Manager in September 2023, with implementation expected to continue until March 2025. Ongoing evaluations, guided by the RE-AIM framework, assess the tool’s impact on reducing community health worker workloads and improving linkage-to-care efficiency. Additionally, we plan to translate the chatbot into local languages to enhance accessibility and scale it up for broader use in programmatic settings.

CONCLUSIONS

Documenting the development of mHealth technologies is crucial for guiding future projects and improving health interventions. In our study, frameworks like design thinking and the health belief model aligned the eCase Manager with user needs and programmatic goals. This approach addressed challenges in TB linkage-to-cares and allowed for iterative improvements through stakeholder feedback. Sharing this process offers insights for future mHealth developers, helping them tackle common issues like limited human resources and patient engagement. Comprehensive documentation may help assess the chatbot's performance and guide future improvements, supporting scalability and efficiency in mHealth interventions across public health settings.
Google Trends data analysis of hepatitis B and their correlation with hepatitis B early detection program for pregnant women in Indonesia
Authors: Nugraha Dwi Adhi , Pramana Triyanta Yuli
Published: February 2025

Purpose: Hepatitis B is still a problem in Indonesia. National surveillance project [Basic health survey (Riskesdas)] data in 2013 showed the prevalence of hepatitis B surface antigen (HBsAg) was 7.1%. One effort has been made to reduce the transmission of hepatitis B: the hepatitis B early detection program (DDHB) for pregnant women. Early changes in population health may be reflected in shifts in information and communication patterns on the internet. Changes in information and communication patterns on the internet can be an early "symptom" of changes in population health. This study aimed to know the correlation of hepatitis B relative search volume with HBsAg reactive percentage and coverage of the DDHB program for pregnant women in Indonesia.
Methods: The value of relative search volume for hepatitis B in various regions in Indonesia in 2020 based on Google trends correlated with reactive HBsAg percentage and coverage of the DDHB program for pregnant women in 2020. Researchers compared the value of relative search volume for hepatitis B with hepatitis, hepatitis A, and hepatitis C. Spearman correlation analysis test was used to find the relationship between variables.
Results: East Nusa Tenggara had the highest hepatitis B relative search volume and reactive HBsAg percentage in the DDHB program for pregnant women in 2020. Hepatitis B relative search volume was correlated with reactive HBsAg percentage (r=0.618; p<0.001) but did not correlate with DDHB coverage (r=-0.65; p=0.374). The popularity of hepatitis B (19.81±6.68) was higher than hepatitis A (8.65±5.79) and hepatitis C (3.90±1.75) but lower than hepatitis alone (54.08±19.02).
Conclusion: East Nusa Tenggara had the highest hepatitis B relative search volume and reactive HBsAg percentage. Hepatitis B’s relative search volume in Google Trends data analysis significantly correlated with reactive HBsAg percentage in the DDHB program for pregnant women in Indonesia.
Association of body mass index pre-pregnancy with hypertension disorders of pregnancy in Bantul District Special Region of Yogyakarta
Authors: Cahyaningtyas Ayu , Hakimi Mohammad
Published: February 2025

Purpose: This research was to identify the relationship between body mass index pre-pregnancy and the incidence of hypertension in pregnancy in Bantul District in 2020.
Methods: This research used a retrospective cohort design based on secondary data from an online maternal cohort with SIPIA Bantul in the Bantul district in 2020. The effect size was calculated using Relative Risk (RR) from bivariate chi-square, multivariate binomial regression, and stratification by Mantel-Haenszel. The total sample of this research was 670 pregnant women.
Results: Bivariate analysis results showed that there was body mass index pre-pregnancy (RR: 1.45; CI 95%: 1.220  – 1.730; p-value=0,00), mother age (RR: 1.47; CI 95%: 1.243 – 1.745; p-value=0,00), upper arm circumference (RR: 1.45; CI 95%; 1.194 – 1.761; p-value=0,001), and gestational weight gain (RR: 1,34; CI 95%: 1.123 – 1.598; p-value=0,002) have significant association with hypertension in pregnancy in Bantul District 2020. The multivariate analysis showed that body mass index pre-pregnancy and mother's age were the most significant variables with hypertension in Bantul District 2020. The stratification analysis showed that maternal age, upper arm circumference, gestational weight gain, and parity were not confounding. Still, there were modifying effects between body mass index pre-pregnancy and the incidence of hypertension in pregnancy in Bantul District in 2020.
Conclusion: Pregnant women who are overweight and obese can increase the incidence of hypertension in pregnancy in Bantul District 2020. Collaboration with nutritionist workers needs to be done to reduce the incidence of hypertension in pregnancy in Bantul District.
Research on the Team Strategy Indicators and Championship Success Rate of Basketball Players
Authors: Yuan Shizhe
Published: February 2025

This paper aims to explore the relationship between basketball players' team strategy indicators and championship success rate. Through literature review, data collection and empirical analysis, a quantitative model for comprehensively evaluating the strength of basketball teams is constructed. The study found that key factors such as offensive efficiency, defensive intensity, and team tacit understanding have a significant impact on the team's championship probability. Based on this, specific strategies to enhance team competitiveness are proposed, and a theoretical basis is provided for coaches to formulate training plans.
An ornithopod trackway from the Albian-Turonian Arcurquina Formation, Arequipa, Peru, and its paleoecological implications
Authors: Guillermo-Ochoa Angel A. , Zevallos-Valdivia Leonardo M. , Castro-Eguiluz Camila , Garcia-Flores Vilma , Martinez Jean-Noël , Silupú-Cárdenas Omar Alfredo , Sánchez-Alva Claudia Isabel , Epiquien-Llaja José Luis , Pintado-Abarca Thalía del Pilar , Delgado-Quiroz Lizbeth Mariana , Rodríguez-de la Rosa Rubén A.
Published: February 2025

Tracks and trackways of swimming ornithopod dinosaurs are rather rare in the ichnological record; in this paper, a short trackway of a small ornithopod dinosaur is described from Albian-Turonian sediments of the Arcurquina Formation, at Yura District, southern Peru. According to the age and overall footprint morphology, a basal member of Iguanodontia is proposed as the potential trackmaker. The trackway consists of three consecutive tridactyl and mesaxonic footprints, preserved as concave impressions or negative epichnia. The first footprint preserves impressions of digits II to IV with a very low angle of total divarication (7.5°). The second footprint preserves a half-moon shaped plantar impression, with no traces of digits II and IV; however, digit III is observed as an elongate and narrow impression, bearing an acuminate end and a proximal subcircular impression; a sediment mound, behind the impression of digit III is preserved as well. The third footprint preserves the whole impression of digit III, while digits II and IV preserve their most distal ends as sub-triangular impressions. The second step is shortest; this characteristic, as well as the different morphology of the three footprints, can be explained by a scenario in which a small ornithopod dinosaur was in underwater locomotion; however, the action of the waves influenced the locomotion of the producer of the footprints. This finding represents an important addition to the ichnological record of dinosaurs in Peru.
¿A quién le reza un bibliotecario? Wiborada, patrona de los bibliotecarios
Authors: Gonzalez Cornejo Carlos Roberto
Published: February 2025

El trabajo aborda el suceso acaecido a principios del siglo X en la abadía de San Galo; la mística, santa y mártir Wiborada [ca. 861 d. C. - 926 d. C.] tiene una visión sobre la llegada de los magiares al monasterio, lo cual ayudará a salvar y proteger los manuscritos de su biblioteca. Con base en lo anterior, la destrucción de la biblioteca de la abadía de San Galo se nos presenta como un corpus sic, anima non. Principia el estudio con las bibliotecas monásticas medievales, seguido de las Regulae en torno a las cuales se basa el monacato, concluyendo con la figura de la mártir; se alude a las Casus sancti Galli de Ekkehardo IV y a la Vitae Sanctae Wiboradae de Walter Berschin. El trabajo constituye un pequeño homenaje a la vida y obra de Wiborada.
AI-Enhanced Dermatological Diagnostic Tool for Global Skin Health Improvement
Authors: Kowshik Munnangi Krishna
Published: February 2025

There is a need for new and accessible diagnostic solutions globally, as the prevalence of skin disorders increases. This
thesis presents an AI-Enhanced Dermatological Diagnostic Tool which utilizes state of the art machine learning techniques to
augment the powers of the dermatologists in detecting and classifying skin conditions. Our system uses convolutional neural
networks (CNN) trained on various dermatological datasets and is able to efficiently identify diseases including melanoma,
psoriasis, eczema and benign lesions with high accuracy. The proposed tool has the capability to integrate daily demographic
data and patient history to enhance the diagnostic precision and at the same time have a user friendly interface to allow easy
access via mobile and telemedicine platform. It is designed for real time operation, to fill healthcare voids in the under served
areas with rapid, cheap, reliable diagnostic aide. The continuous learning algorithms guarantee the response’s adaptability to
new data, consequently creating a dynamic diagnostic response that changes over time. Pilot trials demonstrate the potential to
reduce diagnostic delays, improve adherence to follow-up care and empower patients for early stage detection and for preventive
care. The work underscore how artificial intelligence will change dermatological diagnostics to help improve global skin health.
Strengthening Financial Inclusion in the Insurance Industry Post-COVID-19: Challenges and Solutions
Authors: Yaacob Najihah Marha , Azman Aminah Jazilah , Zahira Rusli Arina Rus , Najihah Ghazali Nur Mimi
Published: February 2025

Financial inclusion plays a crucial role in driving economic development by ensuring access to essential financial services such as credit, savings, insurance, pension plans and financial education. In the insurance sector, financial inclusion aims to extend insurance coverage to low-income groups and enable them to protect their health, assets and livelihoods through the savings and compensation mechanisms of insurance products. This study seeks to enhance the understanding of financial inclusion in the insurance sector by examining the challenges from both the perspective of the individual customer and the industry. From the customer's perspective, this study highlights whether insurance coverage adequately addresses their financial inclusion needs. From an industry perspective, this study addresses critical issues such as customer trust and perceived value, product customization and the impact of macroeconomic factors. In addition, this study proposes strategic solutions to address the identified challenges for both customers and the insurance industry. For individuals, it is recommended that insurance policies should be seen as a complement to savings and investment strategies and not as a substitute for them. For the insurance industry, it is suggested that insurance companies move beyond traditional sales roles and focus on developing products that are tailored to the needs of the market while remaining affordable. The industry should focus on maximizing value for customers. The findings are anticipated to provide crucial insights that can assist the insurance sector in improving customer financial inclusion and addressing current barriers to progress.
Performance Measurement System in Malaysian Higher Education Institutions: Driving Success or Inducing Stress?
Authors: Muda Rokiah , Adnan Noor Liza , Wan Jusoh Wan Noor Hazlina , Yusoff Rohana
Published: February 2025

An effective performance measurement system (PMS) is crucial for higher education institutions (HEIs) to drive success, but an unfair one may lead to stress and negative behaviors. Currently, academics are expected to excel in various areas, leading to overwhelming tasks and responsibilities. The existing system for evaluating academic performance is considered unfair as it overly prioritizes quantitative measures. The Key Performance Indicators (KPIs) are also perceived as inadequate in capturing the essence of the academic role, which should emphasize content and quality. This study aims to explore Malaysian academics' perceptions of the performance measurement system adopted by HEIs, their views on what constitutes a fair measurement system, and their opinions about the current system. This study targeted academics at Malaysian HEIs using convenience sampling due to the large number of institutions. A total of 379 participants responded to an online survey distributed via email with the help of university representatives. The instrument included sections on demographics, perceptions of PMS, opinions on fair PMS, and open-ended questions, utilizing a slider scale for precise data collection. The findings indicate that higher education institutions tend to adopt a directive performance measurement approach, relying heavily on quantitative indicators for monitoring. To create a fairer system, emphasis should be placed on effort and qualitative measures. Many academics express frustration over the numerous measures employed in the PMS, contributing to their excessive workload and work-life imbalance. Therefore, a fairer measurement system is needed to ensure a better work-life balance and reduce stress for academics.
Исследование уровня развития критического мышления у подростков
Authors: Афоничев Г.А. , Яковлева Е.В.
Published: February 2025

Статья посвящена вопросу диагностирования уровня развития критического мышления у подростков, обучающихся в общеобразовательной организации. В работе доказана необходимость формирования критического мышления у учащихся, приведен анализ понятия «критическое мышление», на основе анализа определены критерии и показатели сформированности критического мышлении у подростков, дана характеристика уровней. В статье указаны диагностические методики, которые позволяют определить уровень сформированности критического мышления у учащихся 8–9 классов. Представлены результаты замеров уровня развития критического мышления у подростков.

The article considers diagnostics of the level of’critical thinking development of adolescents studying in a comprehensive educational institution. The study substantiates the necessity of fostering critical thinking in students and provides an analysis of the concept of "critical thinking." Based on this analysis, criteria and indicators of critical thinking formation in adolescents are identified, and a description of its developmental levels is given in the article. The article specifies diagnostic methodologies that allow for the assessment of the level of critical thinking development in 8th–9th grade students, and gives the results of measurements of adolescents' critical thinking development.
EXPLORING THE PARADOXES OF TOURISM: HOW MEMORABLE EXPERIENCES, CITY BRANDING, AND DESTINATION IMAGE INFLUENCE REVISIT INTENTIONS?
Authors: Astuti Widji , Natsir Mokhamad , Elmas Muhammad
Published: February 2025

This study addresses a critical gap in tourism literature by examining how memorable tourism experiences, city branding, and destination image collectively influence revisit intention through tourist satisfaction in Batu City Tourism Village. Using Structural Equation Modeling (SEM) on data from 155 visitors surveyed within six months of their visit, the results show that while memorable experiences and city branding enhance satisfaction, they do not directly impact revisit intention. In contrast, destination image significantly influences revisit intention, highlighting its critical role in shaping tourist behavior. The findings challenge the assumption that positive experiences and strong branding alone ensure return visits, emphasizing the complexity of tourist decision-making. Additionally, tourist satisfaction mediates these relationships but proves insufficient on its own to guarantee revisit intention. These insights underscore the need for dynamic tourism strategies that prioritize enhancing destination image while offering compelling reasons for tourists to return, ensuring alignment with evolving preferences and expectations.
Как исторически остались незамеченными собственные корпускулярно-волновые величины микрочастиц.
Authors: Джомирзоев Субхон
Published: February 2025

После обнаружения в 1905 году Эйнштейном у фотона корпускулярно-волнового дуализма (КВД), спустя двадцать лет де Бройль предположил, что КВД присуща и другим микрочастицам. Теперь же, мы обнаружили, что истроически за КВД микрочастиц остались незамеченными собственные корпускулярно-волновые величины (КВВ) микрочастиц. Походу удалось уточнить, что предложенное Эйнштейном формула КВД фотона не являлось корпускулярно-волновой формулой, а являлось корпускулярно-частотной формулой.
FUNGSI DAN NILAI MANTRA DALAM RITUAL UPACARA MUNCANG KUTA SUKU KARO
Authors: Karo Marlisnawati Br , Perangin-angin Alemina Br.
Published: February 2025

Penelitian ini fokus membahas mengenai mantra dan nilai dalam ritual upacara Muncang kuta dalam adat suku Karo yang diangkat dari kisah nyata yang terjadi di desa Mbaruai, yang merupakan pendiri kuta Mbaruai yakni Marga Tarigan Tambak, marga pertama di desa Mbaruai. Di dalam ritual upacara muncang ini menggunakan mantra Untuk mengungkapkan fungsi dan nilai-nilai budaya di dalam acara ritual upacara muncang kuta. dikaji melalui kajian antropologi sastra antara lain, nilai budaya hubungan manusia dengan Tuhan, nilai budaya hubungan manusia dengan alam, nilai budaya hubungan manusia dengan manusialain, nilai budaya hubungan manusia dengan masyarakat dan nilai budaya hubungan manusia dengan diri sendiri. Dalam penelitian ini menggunakan metode penelitian kualitatif deskriptif untuk mendapatkan data yang diinginkan. Dalam penelitian ini terdapat 9 mantra. Dalam penelitian ini juga menemukan fungsi mantra diantaranya adalah fungsi religius, sosial, spiritual, perlindungan, penyembuhan, serta pewarisan tradisi. Penelitian ini dilakukan untuk mempertahankan adat dan budaya yang ada di Masyarakat suku KaroKata Kunci: Fungsi, Mantra, Ritual Upacara Muncang Kuta.
Pembentukan dan Pemaknaan Idiom dalam Bahasa Indonesia: Kajian Semantik Kognitif
Authors: Siagian Beslina Afriani , Simaremare Juni Agus , Saragih Renita , Situmorang Enjelina
Published: February 2025

Penelitian ini meneliti idiom bahasa indonesia dengan menggunakan kajian semantik kognitif. Tujuan utama dari penelitian ini adalah untuk menunjukkan bagaimana bingkai (frame), ranah (domain), dan pemaduan konseptual (conceptual blending) berperan pada pembentukan idiom bahasa Indonesia. Penelitian ini menjawab rumusan masalah yang berkaitan dengan pembentukan dan pemaknaan Idiom. Data penelitian dikumpulkan dengan memanfaatkan berbagai data tulis sebagai data primer dan berbagai data lain yang dapat mendukung penelitian ini. Seluruh data tersebut dianalisis dengan menggunakan berbagai teknik analisis bahasa, seperti sisip, perluas, ubah wujud, lesap, ganti, dan balik. Untuk memastikan data-data yang diperoleh, digunakan triangulasi sumber dan metode. Hasil penelitian menunjukkan bahwa penutur bahasa Indonesia memiliki kemampuan kognisi yang sangat baik dalam menggambarkan makna melalui idiom. Uniknya, idiom tersebut diperoleh berdasarkan penamaan organ tubuh manusia yang membuat idiom lebih mudah dipahami dan digunakan dalam komunikasi sehari-hari.
PENGEMBANGAN E-MODUL BERBASIS STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) PADA MATERI OPTIKA GEOMETRI KELAS XI SMA
Authors: Gisriani Junija , Sahyar Sahyar
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan E-modul berbasis STEM pada materi optika geometri dan menganalisis kelayakannya dari segi validitas, kepraktisan, dan keefektifan. Jenis penelitian yang digunakan adalah Research and Development (R&D) dengan model ADDIE. Teknik pengumpulan data meliputi angket validitas, respon guru dan peserta didik, serta tes hasil belajar berupa pretes dan postest. Penelitian ini melalui tahapan analisis, desain, pengembangan, implementasi, dan evaluasi. Subjek penelitian terdiri dari dua dosen fisika sebagai validator, serta guru fisika dan peserta didik kelas XI-2 dan XI-3 SMA Negeri 1 Aek Kuo. Hasil penelitian menunjukkan tingkat validitas E-modul dengan rata-rata 90% (sangat valid), kepraktisan dengan rata-rata 89% pada uji coba respon guru, 83,8% pada uji coba kelompok kecil, dan 86,1% pada uji coba kelompok besar. Keefektifan E-modul dilihat dari N-gain sebesar 0,71, menunjukkan peningkatan signifikan dalam hasil belajar peserta didik. E-modul berbasis STEM ini valid, praktis, dan efektif. Kata Kunci: E-Modul, STEM, Optika Geometri.
Pengaruh Inquiry Learning terhadap Hasil Belajar Siswa pada Materi Gelombang Bunyi di SMA
Authors: Sihotang Lilis Susanti , Hakim Abd
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran inkuiri terbimbing terhadap hasil belajar fisika siswa SMA pada gelombang Bunyi. Penelitian ini merupakan jenis penelitian Quasi eksperimen dengan desain two group pretes postes design. Populasi dalam penelitian ini adalah seluruh kelas XI MIPA SMAN 2 Percut Sei Tuan T.P 2022/2023 dan sampel dalam penelitian ini adalah kelas XI B (kelas eksperimen) dan XI A (kelas kontrol) yang diambil dengan cara cluster random sampling. Instrumen yang digunakan adalah tes hasil belajar berbentuk pilihan berganda sebanyak 10 soal dan aktivitas siswa dengan menggunakan lembar observasi. Hasil penelitian diperoleh bahwa nilai rata- rata pretest dan postest di kelas eksperimen adalah 28,33 dan 72,66 sedangkan di kelas kontrol adalah 30,66 dan 64,66. Analisis data dilakukan dengan uji t diperoleh bahwa  = . Sehingga dapat disimpulkan bahwa ada pengaruh yang signifikan dari model pembelajaran inkuiri terhadap hasil belajar siswa pada materi gelombang bunyi.Kata Kunci: Inquiry Learning , Hasil Belajar, Gelombang Bunyi
PEMANFAATAN MODEL INKUIRI TERBIMBING PADA MATERI POKOK USAHA DAN ENERGI
Authors: Tumanggor Elisabeth Pransiska , Doloksaribu Maryati
Published: February 2025

Penelitian ini bertujuan untuk mengetahui dampak model pembelajaran inkuiri terbimbing terhadap hasil belajar siswa pada materi usaha dan energi. Jenis penelitian ini adalah quasi experiment. Populasi dalam penelitian ini adalah seluruh siswa kelas X SMK Negeri 2 Medan. Pengambilan sampel dilakukan dengan teknik simple random sampling yang terdiri dari dua kelas, yaitu kelas X TITL-3 sebagai kelas eksperimen yang berjumlah 25 orang dan kelas X BKP-2 sebagai kelas kontrol yang berjumlah 25 orang. Instrumen yang digunakan adalah tes hasil belajar dalam bentuk pilihan berganda yang terdiri dari 20 soal yang telah divalidasi oleh validator. Berdasarkan hasil penelitian diperoleh rata-rata postes kelas eksperimen 46 dan kelas kontrol 32,6. Analisis uji t dapat disimpulkan ada penerapan model pembelajaran inkuiri terbimbing terhadap hasil belajar.Kata Kunci: Inkuiri terbimbing, hasil belajar, quasi esperiment, uji-t
El valor pragmático de las herramientas multimodales en las conversaciones virtuales
Authors: Lumbreras Mayans Julia
Published: February 2025

El objetivo del presente artículo es estudiar los fenómenos lingüísticos ligados a la pragmática que se propician dentro de la mensajería instantánea. Se ha seleccionado un corpus de conversaciones de chat de la plataforma WhatsApp a partir de un grupo social compuesto por siete informantes. El análisis atenderá dos cuestiones de los estudios pragmáticos que presentan un desarrollo llamativo dentro de un contexto virtual: las diferentes herramientas multimodales que se emplean y las funciones pragmáticas que desempeñan en el grupo social, así como la distribución visual del chat y de qué manera esta puede ofrecer información inferencial.