bluuebunny/crossref_metadata_2025 huggingface dataset:
Arrimage entre le RSSS et les
municipalités dans le programme MADA : une analyse selon un modèle de la
gouvernance collaborative
Authors: Goudreault Nicolas , Garon Suzanne , Veil Anne , Lévesque Nancy
Published: July 2021

Cadre de la recherche : Le
vieillissement de la population est particulièrement rapide au Québec et
s’accompagne d’une diminution du soutien aux personnes âgées (Maltais, 2018). De
surcroît, les aînés représentent un groupe social à haut risque d’isolement
social avec les conséquences importantes sur leur santé qui s’ensuivent
(Holt-Lunstad et al., 2017). Ces problématiques
requièrent la mise en place de programmes nationaux pour veiller au bien-être
des aînés, tel le programme Municipalités amies des aînés (MADA). Or, le
partenariat actuel entre les acteurs municipaux et ceux du RSSS est défaillant
et diminue son apport à la démarche.

Objectifs : Exposer les écueils qui
entravent le partenariat intersectoriel dans le programme MADA entre la
municipalité et le réseau de la santé et des services sociaux (RSSS), selon le
modèle de la gouvernance collaborative d’Ansell et Gash (2007). Dégager des
pistes de réflexion fondées sur des expériences réalisées au Québec. L’analyse
de celles-ci pourrait servir à améliorer le partenariat intersectoriel et,
ultimement, à mieux répondre aux besoins de la population vieillissante.

Méthodologie : Pour illustrer l’état
actuel du partenariat entre les acteurs municipaux et ceux du RSSS, nous avons
eu recours à une méthode qualitative suivant trois dispositifs : 1) une
recension sommaire des écrits; 2) les résultats de recherche de l’équipe de
recherche MADA-Québec; 3) des entrevues avec les acteurs du milieu (aux niveaux
stratégique, gestionnaire et opérationnel).

Résultats : Les entrevues ont permis de
faire ressortir les écueils présents dans le partenariat intersectoriel au
niveau des conditions préalables, selon le modèle de gouvernance collaborative
d’Ansell et Gash. Elles ont également aidé à identifier des expériences
réalisées au Québec qui peuvent servir de pistes de réflexion pour rétablir le
partenariat intersectoriel.

Conclusion : Le partenariat entre
acteurs municipaux et RSSS doit être optimisé afin d’assurer une réponse
adéquate aux besoins des aînés dans la démarche MADA.

Contribution : L’analyse selon le modèle
d’Ansell et Gash démontre une faiblesse du partenariat intersectoriel dans la
démarche MADA. Les expériences présentées pourront inspirer de nouvelles
pratiques prometteuses à cet égard.
Percepción del alumnado sobre su competencia comunicativa en la formación inicial docente: una experiencia interdisciplinar
Authors: Korres Alonso Oihane , Balerdi Eizmendi Eneko , Paños-Castro Jessica
Published: July 2021

La competencia comunicativa es una de las competencias clave en la formación inicial docente y la planificación coordinada entre distintas asignaturas hace su desarrollo más significativo. La comunicación es fundamental en el proceso de enseñanza y aprendizaje y, por tanto, sus aspectos escritos, orales y no verbales han de ser cuidados. Este estudio analiza la autopercepción de la competencia comunicativa del alumnado universitario tras la aplicación de un proyecto interdisciplinar, cuyo objetivo es integrar las distintas destrezas comunicativas por medio de metodologías de enseñanza-aprendizaje activas y coordinadas en colaboración académico-profesional con sesiones teóricas y talleres con expertos. Para ello, se ha implementado un programa de formación longitudinal dirigido a 53 alumnos del Grado de Educación Primaria, en el que han creado un cuento escrito en el primer curso, transformándolo al formato oral y al escénico en cursos posteriores. A partir de las rúbricas de las competencias genéricas de la Universidad de Deusto, se diseñó un cuestionario mixto ad-hoc. Una vez validado el cuestionario por expertos, se procedió a la recogida de datos. Los resultados muestran una valoración generalmente positiva y críticamente constructiva. Asimismo, señalan un aumento en su motivación, porque los talleres contribuyen a una mejor comprensión de los contenidos de las asignaturas, subrayando su carácter práctico. Así, se debe fomentar el trabajo colaborativo interdisciplinar en la formación inicial del profesorado, implementando experiencias de aprendizaje integrales e integradoras.
MODELS OF UTILITY CADASTRE IN BOSNIA AND HERZEGOVINA
Authors: Skorup Dragana
Published: July 2021

The utility cadastre database is a basic set of data about utilities, property rights pertaining to them and property rights holders. The beginning of utility cadastre in Bosnia and Herzegovina is referred to cadastre of communal facilities in the Socialist Federal Republic of Yugoslavia (SFRY) and the Socialist Republic of Bosnia and Herzegovina (SR BiH). In Bosnia and Herzegovina there are two types of records: utility cadastre and cadastre of communal facilities. The main difference between these two models is that the utility cadastre also contains the information about property rights pertaining to them and property rights holders which is not the case with the cadastre of communal facilities. The paper will give an overview of utility records in BiH and point out some important characteristics of particular models of utility records in the Republic of Srpska, Federation of Bosnia and Herzegovina and Brčko district of Bosnia and Herzegovina.
Basic Production Parameters of Small Capacity Broiler Farms in the Region of Banja Luka
Authors: Vekić Marinko , Klincov Živko , Jotanović Stoja , Savić Đorđe
Published: July 2021

This paper presents the basic production parameters of seven broiler farms with a capacity of 6,000 birds per round in the Banja Luka region, obtained by analysis of production records of 70 rounds, achieved in 2013-2014. Methods of descriptive statistics, one-way analysis of variance and correlation analysis were used. Average values of production parameters were as follows (M±SD): day-old chick weight 43.04±2.63 g; fattening duration 38.91±2.55 days; final chick weight 2.13±0.24 kg; feed conversion ratio 1.80±0.07; total mortality rate 4.07±1.95%, and European production efficiency factor 291.14±22.50. Significant differences were found for average total mortality rate among broiler farms and feed conversion ratio between production years (p0.05). Fattening duration was in positive correlation with feed conversion ratio (0.76, p0.01), final chick weight (0.90, p0.01), but in negative with EPEF (-0.28, p0.05). Comparable production performances could be related to uniform the technology and similar requirements of meat industry, although comprehensive research is suggested for reliable evaluation of broiler farm productivity in the Banja Luka region.
The Degrees оf Soil Suitability in the Municipality of Bužim for the Purpose of Cultivating Potato (Solanum tuberosum L.)
Authors: Ičanović Mirsad , Marković Mihajlo , Kudić Husnija
Published: July 2021

Rational use of available land is of great importance for the economic development of every society, especially when considering the fact, that the soil is a primary production resource, thereby placing an even greater importance on its protection and conservation, but also on the correct use of it. This paper focuses on the municipality of Bužim, located in the north-western part of Bosnia and Herzegovina, where we assessed and examined the soil suitability for the purposes of potato cultivation by using the FAO methodology of AEZ (agro-ecological zoning), which uses input data such as soil characteristics, climate changes, relief patterns of the investigated area, and the requirements of the agricultural crops. Within the municipality of Bužim, 13,026.27 ha of land is used for agricultural purposes. In regards to the potato cultivation, one distinguishes between two categories of soil suitability: the suitable classes (S1, S2, S3) which occupy more than 45% of the land surface, and the unsuitable class (the N class) which only occupies 1.43% of the land surface. Thus, it can be concluded that conditions necessary for potato production do exist within the municipality of Bužim in the form of land resources, and higher yields can be achieved by implementing landscaping measures and introducing new potato varieties in accordance with the latest scientific and expert achievements.
The presence of heavy metals in water and the muscle tissue of grayling (Thymallus thymallus) of the Una River
Authors: Bakrač Azra , Džafić Subha , Dekić Radoslav , Ičanović Irma
Published: July 2021

Heavy metals belong to a group of substances, which, after reaching a natural habitat, can manifest various negative effects. This paper analyses heavy metals (Cu, Cd, and Pb) in the Una river and fish samples, whereby individuals of grayling (Thymallus thymallus) were used for analysis. The samples were taken at three locations at the Una river: Ripač, Hatinac, and Grmuša. Alongside with the examination of the content of heavy metals, quality of water was tracked, including the following parameters: temperature, pH, electrical conductivity, dissolved oxygen, suspended matter, BPK5, KPK – Cr, total nitrogen – N, total phosphorus P, sulphates, chlorides, nitrites – NO2, nitrates – NO3, fluoride, and heavy metals (Cu, Cd, and Pb). Besides the content of heavy metals, proteins, fats, water, carbohydrates, and mineral matter were found in the grayling fillets. Amount of heavy metals (Pb, Cu, and Cd) were under maximum allowed concentration (MAC).
The agricultural value-chain extension model: concepts and applications in Africa
Authors: Oladimeji Oladele Idowu
Published: July 2021

This paper describes the Agricultural Value Chain Extension Model after examining different extension models and differentiated terminologies related to evolution of extension models. Agricultural extension is a common denominator for functional value-chain and food security such that agricultural development outcomes are closely linked to agricultural advice provided by extension services. This model consists of five components of formal training, key clusters, informal training, value chain actors and value chain centre interlinked and connected with forward and backward linkages with overlapping activities among the key clusters. All of these interplay based on the level of funds and resources available for the activities connecting the components and the pervasiveness of the national agricultural policy where it is deployed. The paper concludes with the application of the Value-Chain Extension Model, by an International Non-Governmental Organization providing extension services along the value chain in Africa.
Organosomatic indices and leukocyte formula of chub (Squalius cephalus L) from the Suturlija River
Authors: Bakrač Azra , Džafić Subha , Dekić Radoslav , Ičanović Irma
Published: July 2021

Coefficients of organs, along with haematological characteristics, represent an important means of monitoring the health and condition of fish. Organosomatic indices show the state of organ systems and individual organs. They manifest as changes in size, which are reflected through a decrease or increase, under the influence of environmental factors. Chub individuals from the Suturlija River were used for analysis. The paper analyses the Fulton's condition factor, heart, liver, and spleen coefficients as a condition factor. Furthermore, the values ​​of total length, standard length, and body weight were determined for all individuals. Also, certain haematological parameters were analysed in the paper: total leukocyte count and differential blood count. A total of 19 chubs caught from the Suturlija River were analysed. The obtained result of Fulton's condition factor (1.53) indicates favourable habitats for chub individuals in the Suturlija River. The results of organosomatic indices are without major variations between individuals (CSI = 0.184, SSI = 0.992, HSI = 0.133). The mean leukocyte count was 45.857x109/l, with the highest proportion of lymphocytes in the differential blood count.
Niños y niñas chilenos adoptados por familias suecas. Proximidad diplomática en tiempos de Guerra Fría (1973-1990)
Authors: Alfaro Monsalve Karen , Morales José Luis
Published: July 2021

Objective/Context: This article seeks to understand the characteristics and political implications of the process that allowed the adoption of Chilean children by Swedish parents during the military dictatorship in Chile. Methodology: The research is based on the review of diplomatic documentation corresponding to the Chilean Embassy in Sweden, specifically on reports that described the dissemination of the image of Chile and its children in the Swedish media between 1973 and 1990. In addition, reports, periodicals, and official records were consulted that expressed the reaction of the Chilean authorities to criticism received from the Swedish press for irregularities in the adoptions of children. Originality: The political and diplomatic framework for the regulation of international adoptions in the context of military dictatorships in Latin America has been poorly addressed from the humanities and social sciences since interest has been focused on the search for origins by adopted people and their biological families. Hence, this work’s contribution to the historiography of adoptions lies in its focus on the political and diplomatic dimensions of the phenomenon, on the scope of forced mechanisms in the circulation of children to first world countries, as well as on regulatory policies regarding children and family. Conclusions: Based on the revised documentation, it is feasible to conclude that the adoptions of Chilean children by Swedish families were part of a campaign of the military dictatorship to promote adoption, which worked as a counter-propaganda to stop “anti-Chilean campaign” in Sweden, as well as to recover international ties.
Cuarto Congreso de la Cultura Negra de las Américas (1989-1991). Condicionantes históricos y tensiones epistémicas de un congreso fallido
Authors: Valero Silvia
Published: July 2021

Objective/Context: The paper aims to analyze the final period of the project of the Fourth Congress of Black Culture in the Americas and the process by which historical events on both sides of the Atlantic—such as the fifth centenary of the “discovery” of America, claims against the apartheid, the opening of the European Economic Community, and the multicultural turn of Latin America—constituted their conditions of possibility at the same time of limiting their realization. Methodology: With intellectual history as a methodological tool for microhistory, the article examines the power game and the tensions and contradictions that this entailed between—and within—funding agencies and black intellectuals when defining the philosophical and historical foundations of what the congress should be. Originality: The article makes a contribution in analytical terms, through its transnational approach, as well as a cross-analysis of primary sources unexplored by researchers. Conclusions: Social actors—agencies, institutions, individuals as political actors—adopted different logics of participation that were not as coherent and homogeneous as expected. Non-governmental organizations, such as the UNESCO and the Mitterrand Foundation, played a fundamental role in what was envisioned for the realization of the event, as well as in its cancellation.
Comparing audio- and video-delivered instructions in dispatcher-assisted cardiopulmonary resuscitation with drone-delivered automatic external defibrillator: a mixed methods simulation study
Authors: Kim Hyun-Jung , Kim Jin-Hwa , Park Dahye
Published: July 2021

This study compared first responders’ cardiopulmonary resuscitation (CPR) performance when a dispatcher provides audio instructions only and when both audio and video instructions are given. In the simulation, an automatic external defibrillator (AED) was delivered via drone in response to a cardiac arrest occurring outside a hospital setting. Participants’ qualitative experiences were also explored.An exploratory sequential mixed methods design was used. AEDs were delivered to college students via drone with one group receiving both audio and video instructions and the other receiving audio-only instruction, and differences in CPR performance and accuracy were compared. After completion, focus group interview data were collected and analyzed. Video-based instruction was found to be more effective in the number of chest compressions (p < 0.01), chest compression rate (p < 0.01), and chest compression interruptions (p < 0.01). The accuracy of the video group for the chest compression region was high (p = 0.05). Participants’ experiences were divided into three categories: “unfamiliar but beneficial experience,” “met helper during a desperate and embarrassing situation,” and “diverse views on drone use.” Our results lay the groundwork for a development plan for providing emergency medical services using drones, as well as the preparation of guidelines for dispatchers on the provision of video instructions.
Associations of individual and joint expressions of ERCC6 and ERCC8 with clinicopathological parameters and prognosis of gastric cancer
Authors: Chen Jing , Li Liang , Sun Liping , Yuan Yuan , Jing Jingjing
Published: July 2021

Background

Excision repair cross-complementing group 6 and 8 (ERCC6 and ERCC8) have been implicated in ailments such as genetic diseases and cancers. However, the relationship between individual and joint expressions of ERCC6/ERCC8 and clinicopathological parameters as well as prognosis of gastric cancer (GC) still remains unclear.

Methods

In this study, protein expressions of ERCC6, ERCC8 and ERCC6-ERCC8 were detected by immunohistochemistry (IHC) in 109 paired GC and para-cancerous normal tissue samples. The mRNA expression was detected in 36 pairs of tissue samples. IHC results and RNA-seq data extracted from The Cancer Genome Atlas (TCGA) were used to explore the clinical value of ERCC6 and ERCC8 expression in GC. We further conducted protein-protein interaction analysis, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, gene set enrichment analysis, and gene-gene interaction analysis to explore the function and regulation networks of ERCC6 and ERCC8 in GC.

Results

Individual and joint ERCC6/ERCC8 expression were significantly higher in adjacent normal mucosa compared with GC tissues. ERCC6 mRNA expression showed no difference in GC and paired tissues, while ERCC8 mRNA was significantly decreased in GC tissues. Protein expression of ERCC6, ERCC8, double negative ERCC6-ERCC8 and double positive ERCC6-ERCC8 and overexpressed ERCC6 mRNA were related to better clinicopathologic parameters, while overexpressed ERCC8 mRNA suggested worse parameters. Univariate survival analysis indicated that the OS was longer when ERCC6 protein expression and ERCC8 mRNA expression increased, and double negative ERCC6-ERCC8 expression was associated with a short OS. Bioinformatics analyses showed ERCC6 and ERCC8 were associated with nucleotide excision repair (NER) pathway, and six and ten gene sets were figured out to be related with ERCC6 and ERCC8, respectively. KEGG pathway showed that ERCC6/ERCC8 related gene sets were mainly involved in the regulation of PI3K/AKT/mTOR pathway. Direct physical interactions were found between ERCC6 and ERCC8.

Conclusions

Individual and joint expressions of ERCC6/ERCC8 were associated with clinical features of GC. Protein expression of ERCC6, ERCC6-ERCC8, and mRNA expression of ERCC8 were related to prognosis of GC. ERCC6 and ERCC8 primarily function in the NER pathway, and may regulate GC progression through the regulation of PI3K/AKT/mTOR pathway.
Investigation of Different Commercially Available Real Time-Polymerase Chain Reaction Kits for SARS-CoV-2 Diagnosis
Authors: Jain Rajeev Kumar , Perumal Nagaraj , Shrivastava Rakesh , Ahirwar Kamlesh Kumar , Lalwani Jaya , Chaurasia Deepti
Published: July 2021

Introduction: The whole world is facing an ongoing global health emergency of COVID-19 disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Real-Time Reverse Transcription-Polymerase Chain Reaction (RT-PCR) is a gold standard in the detection of SARS-CoV-2 infection. Presently, many single tube multiple gene target RT-PCR kits have been developed and are commercially available for Coronavirus Disease 2019 (COVID-19) diagnosis. Aim: To evaluate the performance of seven COVID-19 RT-PCR kits (DiagSure, Meril, VIRALDTECT II, TruPCR, Q-line, Allplex and TaqPath) which are commercially available for COVID-19 RT-PCR diagnosis. Materials and Methods: This observational study was conductedat the State Virology Laboratory (SVL), Gandhi Medical College, Bhopal, Madhya Pradesh, India. Seven commercially available kits have been evaluated on the basis of: (i) number of SARS-CoV-2 specific gene target; (ii) human housekeeping genes as internal control; (iii) RT-PCR run time; and (iv) kit performances to correctly detect SARS-CoV-2 positive and negative RNA samples. A total of 50 RNA samples (left over RNA) were included, master mix preparation, template addition and RT-PCR test has been performed according to kits literature. At the end of PCR run, mean and standard deviation of obtained cut-off of all kits were calculated using Microsoft Excel. Results: All seven RT-PCR kits performed satisfactory regarding the reproducibility and they could correctly identify 30 positive and 20 negative RNA samples. RNA samples (group C) having low viral loads with a high Cycle threshold (Ct) value (>30) were also detected by all these seven kits. Obtained Ct values of each group was in parallel range in comparison with the initial testing Ct values. Kits were found to be superior which contains primers and probes for three SARS-CoV-2 specific gene targets, have human housekeeping gene as internal control and taking less time to complete RT-PCR. Conclusion: All seven COVID-19 RT-PCR kits included in this study demonstrated satisfactory performance and can be used for the routine molecular diagnosis of COVID-19 disease.
COMBINATION OF METFORMIN AND CURCUMIN THERMOREVERSIBLE NASAL IN SITU GEL FORMULATION AND IN VITRO-EX VIVO EVALUATION FOR DIABETES-INDUCED ALZHEIMER’S DISEASE
Authors: Anku Anuja , Abbulu K. , Battu Sowjanya , Marryswarnalatha Kalam , Sri Lakshmi T.
Published: July 2021

The present research was focused to prepare the formulation containing combination of Metformin and Curcumin to control diabetes-induced Alzheimer’s in elderly population with the utilization of Poloxamer P188 (8%), a thermoreversible gelling polymer, and mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K100 in varying concentrations (0.5%, 1%, 1.5% and 2% respectively) to improve the absorption of drugs by increasing the contact time with nasal mucosa. The in situ gel was prepared by cold method and administered via nasal route to deliver the drug directly to CNS by bypassing BBB and to improve patient compliance, nasal bioavailability of drugs by cumulative its nasal retention time in nasal mucosa. Total 12 nasal in situ gels were prepared and evaluated for in vitro studies and ex vivo drug diffusion studies (goat nasal mucosa) and results were found to be satisfactory. Moreover, histopathological studies revealed that the preparation was safe to be used on nasal mucosa of goat. The prepared nasal in situ gel is an effective alternative to conventional method and can be used to treat diabetes-induced Alzheimer’s disease.
SUB-ACUTE TOXICITY OF A STEROIDAL GLYCOSIDE FROM THE FLOWERS OF ALANGIUM SALVIIFOLIUM WANG
Authors: Anjum Adeeba , Mosaddik Ashik , Wahed Mir Imam Ibne , Haque Md. Ekramul
Published: July 2021

The current study was carried out to investigate the sub-acute toxicity of 3-O--D-glucopyranosyl-(24)-ethylcholesta-5,22,25-triene, a steroidal glycoside isolated from the flowers of Alangium salviifolium Wang on Long Evan’s rat. After intra-peritoneal administration of the compound at a dose of 300 μg/rat/day for 14 consecutive days, no mortality or significant changes in body weight or behavior were observed. The blood samples of the rats were examined for hematological and biochemical parameters which were statistically insignificant when compared to that of the control group. All the vital organs showed normal histopathological architecture (heart, lungs, liver and kidney) in comparison to the control group. This preliminary investigation demonstrate that the compound is safe at dose of 300 μg/rat/day for 14 consecutive days. But acute, sub-chronic and chronic toxicity evaluations as well as clinical trials need to be done.
REVIEW ON MEDICINAL PLANTS UNVEILING HEPATOPROTECTIVE ACTIVITY
Authors: G Swarnalatha , M Poojitha
Published: July 2021

Medicinal plants have remained as a godsend for the current scientific advancements in terms of providing dealing with diseases. The current review provides the data regarding the medicinal plants which have been reported for hepatoprotective activity and which are to be reported for treating many disorders of humankind. The review covers the recent and updated data of medicinal plants to treat all kinds of hepatic disorders which are studied by inducing different methods. As the main metabolic center of human body liver plays a major role in disintegrating the drugs and also considered as the main center which can be affected easily due to toxicity and with the other disorders that can be elicited due to excess use of therapeutic drugs or due to mis use of drugs.
Extrusion Technology: A Tool for Value Addition to Food By-Products and Wastes
Authors: Dendegh T. A. , Yelmi B. M. , Abdullahi M. J. B.
Published: July 2021

The food processing industry generates an immense amount of waste and by-products, which leads to major concerns about the environment. However, most of these wastes, such as plant-derived by-products, are still nutritionally adequate for use in food manufacturing processes. Extrusion technology has brought rapid transformation, new research ideas, opportunities and innovations in the food processing industries. Owing to its versatile nature and many advantages it has over other types of processing methods, a wide range of food raw materials could be processed conveniently which are microbiologically safe and also retain nutrients under carefully selected conditions. It is effluents free during processing; therefore, has no negative impact on the environment and fewer worries about waste or effluent disposal. It has been shown by many authors how extrusion technology is applied to process safe and convenient food products from industrial by-products and waste generated during processing. By-products such as bran, grits, hulls, grape pomace, carrot pomace, apple pomace, were combined or formulated with other food such as corn amongst others to make products like biscuits, pasta amongst using extrusion technology. This is carried out under a controlled process and system parameters to ensure the best product quality. Additionally, anti-nutritional factors present in some of these by-products can be minimized by the extrusion process for use as a food additive or in the formulation of balanced foods. This review features the past research on the value addition process by extrusion to food processing by-products and wastes from fruits and vegetables, cereals and pulses and oilseed (cakes) processing amongst others.
Attitude and usage of Contraceptives among Married Couples in Northern Nigeria: A Review
Authors: Francis C. S. , Ahmed A. M.
Published: July 2021

In Nigeria, particularly in Northern Nigeria, low contraception use is one of the most important predictors of high fertility. Traditional methods such as periodic abstinence and coitus interrupts are recommended over modern contraceptives, which include hormonal and non-hormonal options, because they are more effective and have lower failure rates. High rates of unplanned pregnancies, abortions, maternal illness, and mortality are all associated with low contraceptive use. Contrary to popular belief, modern contraception is an important part of maternal, infant, and child health care. The idea of contraception, modern and traditional methods of contraception, couples' attitudes about contraceptive usage, and variables that limit contraceptive use are all discussed in the report. The internet, academic publications, conference papers, and textbooks were used to gather secondary data. Women's attitudes regarding contraception were influenced by myths and misconceptions, opposition from their spouses, religion, traditional beliefs, and habits, according to the study.
Viscoelastic Material Characterization: A Realistic Approach to Stress Analysis
Authors: Zapanta Amor , Talledo Jefferson
Published: July 2021

This paper presents an advanced method in materials characterization for the mold compound material in semiconductor packages to build models that can technically explain the actual warpage or stress observations under different thermal conditions and time history. In the study, the mold compound material characterization was conducted using Dynamic Mechanical Analyzer (DMA) followed by curve fitting to obtain parameters for the computer modeling input requirement. Thermo-mechanical modeling using viscoelastic material properties was conducted on a bi-material test sample model. Results showed that the new characterized viscoelastic material properties exhibited dependence on time and temperature. Slow cool down from post mold cure (PMC) to room temperature resulted in lower warpage or stress. This observed rate dependent response was explained using viscoelastic material properties in contrast to the usual linear elastic material simplification. Thus, a realistic result from stress or warpage analysis could be achieved using viscoelastic material characterization.
Comparative Study of Physiological and Haematological Parameters among Mild and Severe COVID-19 Patients Admitted in Tertiary Care Hospital of Pune District, India
Authors: Palve Suchita Sachin , Chaudhari Pallavi Sachin
Published: July 2021

Background: The COVID-19 pandemic has put global health at stake by creating havoc all over the world, due to which the world, as well as health agencies, are experiencing the greatest challenges. This disease is a health emergency due to its high level of infectiousness and the non-availability of any specific treatment [1].

Objectives: To determine and compare the significance of physiological and haematological parameters in the diagnosis of COVID 19 infection and compare the association of physiological and haematological parameters among mild and severe COVID-19 patients.

Methodology: The present comparative, observational study was carried out in a designated tertiary care hospital, where admission of COVID19 patients in Pune district, India. Various parameters like age, height, weight, BMI, various physiological variables, haematological parameters, and CRP levels were assessed among 202 Mild and 50 severe COVID 19 diagnosed patients on day one of the hospital's stays.

Results: Pearson’s correlation coefficient showed a significant correlation among physiological and haematological variables compared to both groups, especially physiological parameters like SBP and DBP. The results showed that TLC, CRP, NLR, PLR, among COVID 19 patients cans work as important biomarkers to understand the disease prognosis.

Conclusion: Study of physiological and haematological parameters and their interrelation will help in understanding the impact of COVID 19 infection on the reactive inflammatory responses and help in understanding the prognosis of the disease among mild and severe patients.
Contribution of Ayurveda in the Management of Ksheena Shukra Vikara with Special Reference to Asthenozoospermia: A Case Report
Authors: Mohan Manju , Punam Sawarkar , Gaurav Sawarkar
Published: July 2021

Background: Male Infertility is one of the burning issues now a day’s nevertheless disregarded reproductive health problems in India. Incidences of this issue expands day by day because of the disturbing lifestyle pattern. Almost 30-40-% of infertility cases found to be related to male factor. Asthenozoospermia is the most common identifiable anomaly related to male infertility found in semen analysis having reduced motility of sperm.

Aim and Objectives: To assess the efficacy of Ayurvedic management (Shodhana and Shamana Chikitsa) in the management of Ksheena Shukra Vikara w.s.r. to Asthenozoospermia.

Methods: It is a single case study. A 33-year-old male patient who was already diagnosed with Asthenozoospermia for three years approached to Pancharkarma OPD. Sperm motility was only 12%. The patient was treated with Shodhana Chikitsa (Vamana and Virechana with Mahatiktaka Ghritapana and Dashmooladi Niruha Vasti and Uttarvasti with Vidaryadi Ghrita followed by Shamana Chikitsa (Tab Neo Charak Pharmacy, Tab Addyzoa, Chandraprabha Vati, Paripathadi Kashaya, Ashwagandhadi Yamaka, Avipattikar Churna) approximately 3 months. After 3 months, patient-reported improvement.

Results: Assessment of the patient with clinical symptoms and sperm analysis report was done following 3 months. Sperm motility increased up to 40% with increment in sperm count. 

Conclusion: This case report provides us a guideline that infertility associated with Asthenozoospermia can be treated successfully by adopting basic Ayurveda Siddhanta's.
A Bionanozyme with Ultrahigh Activity Enables Spatiotemporally Controlled Reactive Oxygen Species Generation for Cancer Therapy
Authors: Xu Zhen , Zhang Li , Pan Min , Jiang Qunying , Huang Yunjie , Wang Fuan , Liu Xiaoqing
Published: July 2021

Nanozymes hold great potential in nanomedicine, yet biotoxicity limits their clinical translation because of their uncontrolled catalytic activity, artificial inorganic components, and harsh synthesis conditions. Herein, a peroxidase‐like bionanozyme with ultrahigh and photocontrolled catalytic activity through the self‐assembly of biomolecules, hemin, and in situ polymerization of pyrrole in an aqueous solution is reported. Such bionanozymes leverage the specific cues of the tumor microenvironment and precise light‐induced photothermal heating for spatiotemporally controlled reactive oxygen species generation in tumors. The tunable catalytic activity and excellent biocompatibility of the bionanozyme result in high cancer cell apoptosis and tumor growth inhibition in murine models with negligible biotoxicity. This work highlights the potential of biomolecule‐based nanozymes for cancer‐specific therapy. Bionanozymes with ultrahigh and tunable catalytic activity may lay the important foundation for more advanced nanomedicine and biosensing.
An Injectable Multifunctional Dual‐Phase Bead‐Reinforced Gelatin Matrix Permissive of Mesenchymal Stem Cell Infiltration for Musculoskeletal Soft Tissue Repair
Authors: Du Dajiang , Liu Zhen , Niu Wanting , Weng Ding , Lim Teck Chuan , Kurisawa Motoichi , Spector Myron
Published: July 2021

This study develops a novel strategy for regenerative therapy of musculoskeletal soft tissue defects using a dual‐phase multifunctional injectable gelatin‐hydroxyphenyl propionic acid (Gtn‐HPA) composite. The dual‐phase gel consists of stiff, degradation‐resistant, ≈2‐mm diameter spherical beads made from 8 wt% Gtn‐HPA in a 2 wt% Gtn‐HPA matrix. The results of a 3D migration assay show that both the cell number and migration distance in the dual‐phase gel system are comparable with the 2 wt% mono‐phase Gtn‐HPA, but notably significantly higher than for 8 wt% mono‐phase Gtn‐HPA (into which few cells migrated). The results also show that the dual phase gel system has degradation resistance and a prolonged growth factor release profile comparable with 8 wt% mono‐phase Gtn‐HPA. In addition, the compressive modulus of the 2 wt% dual‐phase gel system incorporating the 8 wt% bead phase is nearly four‐fold higher than the 2 wt% mono‐phase gel (5.3 ± 0.4 kPa versus 1.5 ± 0.06 kPa). This novel injectable dual‐phase Gtn‐HPA composite thus combines the advantages of low‐concentration Gtn‐HPA (cell migration) with high‐concentration Gtn‐HPA (stiffness, degradation resistance, slower chemical release kinetics) to facilitate effective reparative/regenerative processes in musculoskeletal soft tissue.
Control of Water Adsorption via Electrically Doped Graphene: Effect of Fermi Level on Uptake and H2O Orientation
Authors: Bagheri Morteza H. , Loibl Rebecca T. , Schiffres Scott N.
Published: July 2021

The interaction of graphene with water molecules under an applied electric field is not thoroughly understood, yet this interaction is important to many thermal, fluidic, and electrical applications of graphene. In this work, the effect of electrical doping of graphene on water adsorption is studied through adsorption isotherms and current–voltage (IV) characterizations as a function of the Fermi level. The water adsorption onto graphene increases by ≈15% and the doping levels increase by a factor of three with a gate‐to‐graphene voltage of +20 or −20 V compared to 0 V for sub‐monolayer adsorption. This change in uptake is attributed to the increase in density of state of graphene upon electrical‐doping, which changes the Coulombic and van der Waals interactions. The water adsorption onto graphene is either n‐ or p‐doping depending on the applied gate‐to‐graphene voltage. The ambi‐doping nature of water onto graphene is due to the polar nature of water molecules, so the doping depends on the orientation of the water molecules.
Nanotextured Surfaces Lead to Differential Wettability of Compound Droplets
Authors: Berli Claudio L. A. , Bellino Martín G.
Published: July 2021

Water interaction with nanotextured surfaces is critical in diverse natural and technological processes. In general, water is not perfectly pure and can often contain low amounts of oily components. Here it is revealed how, contrary to wetting behavior on non‐porous surfaces, a tiny amount of oil can critically influence water wettability on nanopore structures. Surfaces coated with nanoporous thin films are used to show that water droplets undergo a nanopore‐triggered instantaneous meaningful spreading effect when adding parts‐per‐million (ppm) amounts of oil. Remarkably, minute oil fractions affect water wettability on the nanosurface more than large oil fractions. Moreover, the binary droplets exhibit contact angles even smaller than those of pure components. The physical reason behind the peculiar wetting response of nanopore surfaces arising from traces of oil in water can be attributed to spontaneous transport phenomena in the pore network. The ppm level oil‐in‐water composed droplets also show enhanced mobility on the nanoporous surfaces, as evidenced by very small sliding angles. This feature is indeed leveraged to demonstrate a self‐slippery droplet‐surface system. The study unveils that the presence of ultra‐low concentrations of oil can cause distinctive water‐nanosurface interplays, providing a fresh framework in both water‐related nature phenomena and technical applications.
Ultrasensitive WSe2/α‐In2Se3 NIR Photodetector Based on Ferroelectric Gating Effect
Authors: Jin Hyeok Jun , Park Cheolmin , Lee Khang June , Shin Gwang Hyuk , Choi Sung‐Yool
Published: July 2021

The suppression of dark current is crucial for enhancing the sensitivity of photodetectors, particularly for infrared photodetection. In this study, to overcome the low sensitivity of photodetectors in the infrared wavelength range, a photodetector comprising a 2D semiconductor (WSe2) heterojunction and 2D ferroelectric semiconductor (α‐In2Se3) is developed. WSe2 is fully depleted owing to the ferroelectric gating effect of α‐In2Se3; this enhanced the photodetector detectivity. In addition, photoresponsivity is increased because the n‐type α‐In2Se3 formed a PN junction with the p‐type WSe2. Owing to the ferroelectric gating effect of α‐In2Se3, the dark current in the photodetector is suppressed above 103 times, the photoresponsivity is increased 13.8 times from 0.16 to 2.21 A W−1, and the specific detectivity is increased 437 times from 2.18 × 108 Jones to 9.52 × 1010 Jones at a near‐infrared (NIR) wavelength of 980 nm. The proposed WSe2/α‐In2Se3 heterostructure with an ultrasensitive characteristic in the NIR wavelength range, can contribute significantly to practical photodetector applications.
Manganese(III) Acetate Catalyzed Aerobic Dehydrogenation of Tertiary Indolines, Tetrahydroquinolines and an N‐Unsubstituted Indoline
Authors: Niu Xiaokang , Yang Lei
Published: July 2021

A Mn(OAc)3 ⋅ 2H2O‐catalyzed aerobic dehydrogenation of five and six‐membered N‐heterocycles for the synthesis of N‐heteroarenes is reported. Of note, this protocol can be applied to the dehydrogenation of tertiary indolines with various electron‐deficient N‐substituents. Preliminary mechanistic investigations support that a single‐electron transfer pathway might be involved.

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Analysis of Product Sustainability by Using a Risk‐Oriented System Dynamics Model
Authors: Sezer Muruvvet Deniz , Selim Hasan
Published: July 2021

Measuring product sustainability plays a significant role to gain competitive advantage. Nevertheless, while achieving sustainable products, all related risks associated with sustainability should be considered. Previous studies are limited by the lack of the dynamic and multidimensional approaches. However, as the decision‐making environment is constantly changing in the real world, a dynamic decision‐making approach is required. The aim of this study is to develop a dynamic and risk‐driven approach to investigate the product sustainability risks. The proposed approach considers all the related risks and interactions with a holistic view covering environmental, economic, and social sustainability. To deal with the dynamic and multidimensional nature of product sustainability, system dynamics is proposed. The results show that increasing the production capacity of the company and maintaining the production emphasizing innovation have led to improvements on both product sustainability and the main dimensions of sustainability. The realization of Industry I4.0 applications can be an effective strategy for the business to increase product sustainability. This study is supported with a case study implemented in the manufacturing industry to confirm the applicability of the model. This paper is useful for industry and policy makers to observe the potentials impacts of products sustainability risks.
Effect of the TiO2 Nanocrystal Dispersion Over SBA‐15 in the Photocatalytic H2 Production Using Ethanol as Electron Donor
Authors: Torres‐Garcia Nidia L. , Fresno Fernando , Oropeza Freddy E. , Huirache‐Acuña Rafael , de la Peña‐O'Shea Víctor A.
Published: July 2021

In this work, a series of TiO2‐based photocatalysts supported on mesoporous silica SBA‐15, which are synthesized with different wt% (10, 20, 40, 60, and 80) of TiO2, are studied. The catalysts are evaluated in gas‐phase H2 photo‐production using ethanol as an electron donor, observing changes in the hydrogen evolution with the TiO2 loading with an optimum charge of 20% w/w. In addition, the presence of Pt leads to a huge enhancement of the catalytic activity showing also a volcano plot behavior, the 20% w/w again being the best catalyst (895.9 µmol H2 gcat−1). This system also exhibits a high stability without a decrease in the production after 15 h. By means of different characterization techniques, it is possible to determine the interaction among the active phase, the metallic nanoparticle, and the catalytic support. These studies indicate that the use of mesoporous silica SBA‐15 as a support increases the dispersion of the active phase, resulting in an increase in the evolution rate of H2. However, the lowest percentages of TiO2 give rise to amorphous TiO2 particles with high amount of superficial defects increasing the e−‐h+ recombination rate and decreasing the H2 production.
The impact of pancreas compression time during minimally invasive gastrectomy on the postoperative complications in gastric cancer
Authors: Itamoto Kota , Hikage Makoto , Fujiya Keiichi , Kamiya Satoshi , Tanizawa Yutaka , Bando Etsuro , Terashima Masanori
Published: July 2021

Aim

Pancreas compression during minimally invasive gastrectomy causes blunt injury to the pancreas and leads to postoperative complications. However, the extent of practical compression associated with the incidence of postoperative complications remains unknown. This study aimed to evaluate the impact of pancreas compression, particularly the duration of compression, on short‐term outcomes in minimally invasive gastrectomy for gastric cancer.

Methods

This study included 178 patients who underwent laparoscopic or robotic gastrectomy at the Shizuoka Cancer Center in 2018. The total time of pancreas compression during gastrectomy was measured using video‐reviews, and the correlation between the time and surgical outcomes was evaluated.

Results

A duration of 3 min was selected as the cutoff value of pancreas compression time to predict high drain amylase concentration on postoperative day 1 (≥1000 U/L). The incidence of clinically relevant pancreatic fistula (1.5% vs 12.4%, P = .011) and all postoperative complications (12.3% vs 30.1%, P = .010) were significantly higher in the longer‐compression group than in the shorter‐compression group. The multivariable analysis identified longer compression as the only independent risk factor for postoperative complications.

Conclusion

More than a few minutes of pancreas compression during minimally invasive gastrectomy was associated with a higher incidence of postoperative complications.
Stretchable gas barrier films achieved by hydrogen‐bond self‐assembly of nano‐brick multilayers
Authors: Shi Kaiqiang , Xu Xiaozhi , Dong Siyuan , Li Biao , Han Jingbin
Published: July 2021

Inorganic–organic hybrid films containing two‐dimensional nanosheets have shown good gas barrier performance, but moderate tensile property, because of the rigid characteristics of covalent or ionic bonds between the assembly units. In this work, we used LDH nanosheets rich in hydroxyl groups as building units, followed by modification of tannic acid (TA), to assemble with polyethylene oxide (PEO) through hydrogen bonds. Compared with previous work, the tensile property and oxygen barrier performance of (TA@LDH/PEO)n films have been significantly improved. A 50‐bilayer TA@LDH/PEO film, deposited on a 1 mm thick natural rubber substrate, results in a 29× reduction (contrast with bare substrate) in oxygen transmission rate and maintains its good barrier property even under a large elongation of 120%. The excellent tensile and gas barrier properties are attributed to the ductility of hydrogen bond network among building blocks and the significant prolongation of oxygen transmission path induced by LDH nanosheets.
Interactive Force Control Based on Multimodal Robot Skin for Physical Human−Robot Collaboration
Authors: Armleder Simon , Dean-Leon Emmanuel , Bergner Florian , Cheng Gordon
Published: July 2021

This work proposes and realizes a control architecture that can support the deployment of a large‐scale robot skin in a Human‐Robot Collaboration scenario. It is shown, how whole‐body tactile feedback can extend the capabilities of robots during dynamic interactions by providing information about multiple contacts across the robot's surface. Specifically, an uncalibrated skin system is used to implement stable force control while simultaneously handling the multi‐contact interactions of a user. The system formulates control tasks for force control, tactile guidance, collision avoidance, and compliance, and fuses them with a multi‐priority redundancy resolution strategy. The approach is evaluated on an omnidirectional mobile‐manipulator with dual arms covered with robot skin. Results are assessed under dynamic conditions, showing that multi‐modal tactile information enables robust force control while at the same time remaining responsive to a user's interactions.