bluuebunny/crossref_metadata_2025 huggingface dataset:
Health-related quality of life and risk factors associated with spirometric restriction
Authors: Guerra Stefano , Carsin Anne-Elie , Keidel Dirk , Sunyer Jordi , Leynaert Bénédicte , Janson Christer , Jarvis Debbie , Stolz Daiana , Rothe Thomas , Pons Marco , Turk Alexander , Anto Josep M. , Probst-Hensch Nicole
Published: May 2017

The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality of life.

We used data from two large population-based European cohorts: 6698 European Community Respiratory Health Survey (ECRHS) and 6069 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) adult participants. The restrictive pattern was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥lower limit of normal (LLN) and FVC <LLN; an obstructive pattern was defined as FEV1/FVC <LLN independent of FVC. The Physical Component Summary and Mental Component Summary of quality of life were computed using the Short Form-36 questionnaire.

In both cohorts, the restrictive pattern was associated with heavy smoking, being underweight or obese and the coexistence of respiratory symptoms. In univariate analyses, compared with the normal group, both the restrictive and obstructive pattern had significant Physical Component Summary deficits (−2.77 and −2.08, respectively, in ECRHS; −3.25 and −2.14, respectively, in SAPALDIA; all p-values <0.001). However, in models adjusted for sex, age, education, body mass index, smoking, comorbidities and respiratory symptoms, only the restrictive pattern remained significantly associated with Physical Component Summary deficits (p=0.004 in ECRHS; p=0.001 in SAPALDIA).

The restrictive spirometric pattern is associated with deficits in the physical component of quality of life that are partly independent of the presence of respiratory symptoms.
BMP-induced reprograming of the retina into RPE requires WNT signalling in the developing chick optic cup
Authors: Steinfeld Jörg , Steinfeld Ichie , Bausch Alexander , Coronato Nicola , Hampel Meggi-Lee , Depner Heike , Layer Paul G. , Vogel-Höpker Astrid
Published: May 2017

In vertebrates, the retinal pigment epithelium (RPE) and photoreceptors of the neural retina (NR) comprise a functional unit required for vision. During vertebrate eye development, a conversion of the RPE into NR can be induced by growth factors in vivo at optic cup stages, but the reverse process, the conversion of NR tissue into RPE has not been reported. Here, we show that bone morphogenetic proteins (BMP) signalling can reprogram the NR into RPE at optic cup stages in chick. Shortly after BMP application, expression of Microphthalmia associated transcription factor (Mitf) is induced in the NR and selective cell death on the basal side of the NR induces an RPE-like morphology. The newly induced RPE differentiates and expresses Melanosomalmatrix protein 115 (Mmp115) and RPE65. BMP-induced Wnt2b expression is observed in regions of the NR that become pigmented. Loss of function studies show that conversion of the NR into RPE requires both BMP and WNT signalling. Simultanousely to the appearance of ectopic RPE tissue, BMP application induced ectopic retinal tissue in the proximal RPE of the chick optic cup. The newly induced NR is multi-layered and expresses the Visual segment homeobox-containing gene (Vsx2) and the ganglion- and photoreceptor cell markers Brn3α and Visinin are detected. Our results show that high BMP concentrations are required to induce the conversion of NR into RPE, while low BMP concentrations can still induce transdifferentiation of the RPE into NR. This knowledge may contribute to the development of efficient standardized protocols for RPE- and NR generation for cell replacement therapies.
Letters
Authors: Pearson Marian , Schofield Claire
Published: May 2017

MA Education Ltd, St Jude's Church, Dulwich Road, London, SE24 0PB neil.henty@markallengroup.com
How play gives children an understanding of inclusion
Authors: Francis-Pester Dawn
Published: May 2017

In early years settings we hold an important key to shaping every child's future. It is crucial for us to have an awareness surrounding inclusion and to find ways to help children embrace an inclusive society.
Play as a healing process
Authors: Thomas Jeff
Published: May 2017

What is Play Therapy and how can it help children? In part three of our short series, Jeff Thomas explains how it can be used appropriately with children affected by domestic abuse or violence.
Pengembangan Perikanan Budidaya: Efektivitas Program Minapolitan dalam Pengelolaan Perikanan Budidaya Berkelanjutan di Kabupaten Gresik
Authors: Zakiyah Dwi Maulidatuz
Published: May 2017

Budidaya tambak adalah salah satu aktivitas yang dikembangkan di Gresik. Namun, memberikantekanan bagi ekosistem pesisir yakni tingginya konversi lahan mangrove menjadi tambak sertaberbagai dampak negatif terhadap kualitas lingkungan. Selanjutnya, pemerintah Kabupaten Gresikmenerapkan program minapolitan untuk meningkatkan produktivitas tambak untuk kesejahteraanmasyarakat. Pertanyaan penelitian adalah “Bagaimana efektivitas program minapolitan dalampengelolaan budidaya tambak berkelanjutan”. Metode penelitian yang digunakan adalah kualitatif,bertujuan untuk memahami perkembangan aktivitas perikanan budidaya serta pengaruhnyaterhadap kondisi ekonomi, sosial dan lingkungan, melalui survei lapangan, wawancara danpenyebaran kuesioner untuk petambak. Analisis efektivitas dengan mengevaluasi tingkatkeberlanjutan budidaya tambak pada dimensi ekonomi, sosio-teritorial, lingkungan. Hasil penelitianmenunjukkan bahwa budidaya tambak di Gresik memberikan berbagai dampak positif dan negatifbagi perkembangan kondisi ekonomi, sosial dan lingkungan. Berdasarkan hasil evaluasi tingkatkeberlanjutan, diketahui bahwa program minapolitan gagal dan tidak efektif dalam mewujudkanperikanan budidaya berkelanjutan karena tidak adanya kesinambungan dan keseimbangan pada tigaaspek pembangunan berkelanjutan (ekonomi, sosio-teritoral dan lingkungan).Kata kunci: minapolitan, pembangunan berkelanjutan, perikanan budidaya
Evolusi Konsep Ruang Hijau Publik di Kota Semarang pada Awal Abad ke 20 Hingga Sekarang ( Ruang Hijau Publik di Kawasan Candi Baru )
Authors: Wulansari Katiti
Published: May 2017

Peran ruang hijau di lingkungan perkotaan adalah sebagai penyedia fungsi ekologis yang dapat memberikan banyak manfaat sepertimencegah banjir, mengurangi polusi udara, dan mengurangi tingkat suhu udara. Kenyataannya, berdasarkan dokumen Masterplan RTH Kota Semarang 2012, hanya tersisa 10% dari total luas ruang terbuka hijau terutama pada dua kecamatan yang terletak di kawasan Candi Baru, yaitu Kecamatan Candisari dan Gajahmungkur, terlebih kawasan ini oleh Thomas Karsten dulunya dirancang dengan konsep garden city pada tahun 1906.Pertanyaan penelitian adalah: Bagaimana evolusi konsep ruang hijau publik di Semarang sejak awal abad ke XX hingga sekarang dan pengaruhnya terhadap fungsi ekologisnya? Metode yang digunakan dalam penelitian ini adalah metode kualitatif deskriptif dan pendekatan kuantitatif.Hasil yang diperoleh dari penelitian ini adalah bahwa evolusi ruang hijau publik di kawasan Candi Baru juga merubah konsep pemahaman masyarakat tentang ruang tersebut.Peningkatan polusi udara, peningkatan suhu udara, dan peningkatan intensitas banjir dan tanah longsor juga terjadi di Semarang, sebagai akibat dari berkurangnya jumlah ruang hijau publik.Kata kunci: ruang terbuka hijau, ruang publik, garden city, pengaruh, lingkungan
Evaluasi Rehabilitasi Hutan dan Lahan ( RHL ) di Daerah Aliran Sungai ( DAS ) Juwana pada Kawasan Gunung Muria Kabupaten Pati
Authors: Surtiani Yohan , Budiati Lilin
Published: May 2017

Penelitian ini bertujuan mengembangkan model evaluasi program RHL pada DAS Juwana Kawasan Gunung Muria khususnya Desa Klakahkasihan, Plukaran, Bageng, Sitiluhur Kecamatan Gembong Kabupaten Pati serta mengetahui posisi lembaga Dinas Kehutanan dan Perkebunan Kabupaten Pati sebagai lembaga pemerintah yang bertanggungjawab dalam program RHL. Penelitian ini menunjukkan persen capaian program RHL pada DAS Juwana Kawasan Gunung Muria Kabupaten Pati sebesar 65,8 %. Capaian tersebut terdiri dari  ( 1 )  Prasyarat Pelaksanaan Program RHL Berkelanjutan  ( 10% ) ,  ( 2 ) Pengelolaan berbasis ekologi dan perlindungan Sumber Daya  ( 29% ) ,  ( 3 )  Sistem Produksi hutan lestari  ( 4% ) ,  ( 4 )  Peningkatan Partisipasi dan Sosial Ekonomi masyarakat  ( 34% ) ,  ( 5 )  Implementasi Kebijakan RHL  ( 23% ) . Posisi lembaga Dinas Kehutanan dan Perkebunan Kabupaten Pati berada pada posisi grow and build  ( pertumbuhan dan membangun ) . Disarankan kedepan Dinas Kehutanan dan Perkebunan Kabupaten Pati melakukan perbaikan strategi pelaksanaan RHL yaitu  ( 1 )  Penguatan kelembagaan,  ( 2 ) Pengembangan jejaring kerja dan integrasi program & kebijakan lintas sektor dan lintas organisasi untuk pengembangan pelayanan publik.Kata kunci : evaluasi, RHL, co-management, DAS terpadu , stakeholders, kelembagaan
Peran Kelembagaan Adat Dalam Pengadaan Lahan Untuk Pembangunan di Kota Sentani Kabupaten Jayapura Provinsi Papua
Authors: M.Ondikeleuw Haery
Published: May 2017

Pembangunan Kota Sentani pasca ditetapkan sebagai ibukota kabupaten Jayapura mengalami keunggulan atau pertumbuhan yang pesat. Implikasi sebagai kota baru akibat pemindahan ibukota kabupaten dari Kota Jayapura adalah pada peningkatan kebutuhan tanah. Penyediaan tanah untuk mendudukung kegiatan pembangunan secara aksesibilitas terkendala oleh status kepemilikan lahan adat. Untuk kota Sentani, tanah adat yang ada merupakan hak ulayat dari tiga kampung yaitu kampung Sereh, Yobeh dan Ifar Besar. Berdasarkan pada latar belakang tersebut, maka pengadaan lahan yang mengemuka adalah pada bagaimana peran kelembagaan adat dalam pengadaan lahan untuk pembangunan di kota Sentani.Dengan menggunakan metode deskriptif kualitatif dengan analisis sebaran aktifitas guna lahan, analisis sebaran hak ulayat, analisis perbandingan prosedur dan proses pelepasan lahan adat antara perseptif masyarakat adat dan hukum positif serta analisis keterlibatan lembaga adat, di dapatkan temuan bahwa bahwa peran kelembagaan adat masig berperan terbatas, belum optimal. Belum optimalnya peran kelembagaan adat adalah sebagai akibat dari: efektivitas koordiniasi, integrasi, sinkronisasi, simplikasi dan mekanisme (KISSME) belum memadai, lembaga adat belummaksimal menjalankan tugas dan tanggung jawab sebagai pengayom, pelindung, pelayan, pelaku dan pemimpin tertinggi dari norma-norma yang ada.
Influence of smooth muscle contractility by inhibition of crac channels activity
Authors: Kocmálová M. , Kazimierová I.
Published: May 2017

The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non-pregnant myometrium. Lower Orai1 protein expression did not influence the amplitude of contractile response of term-pregnant myometrium, but higher Orai1 expression observed in non-pregnant myometrium was related to the different influence of CRAC blocker on contraction frequency.
The Halosphaeriaceae revisited
Authors: Jones E.B. Gareth , Ju Wen-Ting , Lu Cheng-Lun , Guo Sheng-Yu , Pang Ka-Lai
Published: May 2017

The Halosphaeriaceae is a monophyletic group that shares a common ancestor with Microascaceae and, along with the families Graphiaceae, Ceratocystidiaceae, Chadefaudiellaceae and Gondwanamycetacea, is referred to the order Microascales. It constitutes the largest family in Microascales with 63 genera (166 species) and differs from other families in that most species are aquatic (predominantly marine) and characterised by perithecial ascomata, centrum tissue comprising catenophyses, clavate to fusiform asci that generally deliquesce early, hyaline, unicellular to many times septate ascospores usually with appendages. Although approximately 75% of halosphaeriaceous species have been sequenced, their phylogenetic grouping based on morphological features is not supported. This indicates that certain characters have evolved and been lost several times. New sequences have been generated in this study; a phylogenetic analysis based on the 18S and 28S rDNA was run to determine phylogenetic relationships between genera, and pairwise distance of the partial 28S rDNA was calculated.
Hermite Pseudospectral Method for the Time Fractional Diffusion Equation with Variable Coefficients
Authors: Liu Zeting , Lü Shujuan
Published: May 2017

We consider the initial value problem of the time fractional diffusion equation on the whole line and the fractional derivative is described in Caputo sense. A fully discrete Hermite pseudospectral approximation scheme is structured basing Hermite-Gauss points in space and finite difference in time. Unconditionally stability and convergence are proved. Numerical experiments are presented and the results conform to our theoretical analysis.
Aproximación al estudio de las formas de representación de los actores armados en justicia y paz
Authors: Suárez González María Teresa
Published: May 2017

El propósito del presente artículo es presentar una aproximación a la manera como se construyen los actores discursivos en la Ley 975 de 2005 (Ley de Justicia y Paz) en Colombia. Se toman como base los procesos de inclusión y exclusión de actores, desde estrategias lingüísticas soportadas en recursos de diversa índole.

El proceso investigativo comprometió tres fases: a) Descripción del corpus y proceso analítico, a partir de la estadística textual, identificación de recursos y estrategias, construcción de categorías; b) Análisis de resultados; c) Interpretación de resultados en clave social y cultural.
THE ACCOUSTIC OBSERVATION AND THE EXPLOITATION OF THE PURSE SEINE FISHERY IN THE JAVA SEA
Authors: Nugroho Duto , Pasaribu Bonar P , Siregar Vincent P.
Published: May 2017

Several acoustic surveys were carried out during a period of 1992 to 1995 in the main flshing ground of the pelagic fishery in the Java Sea. The collaboration between Indonesia and French made up within the frame of Pelfish Project.
Festivales afromusicales en Estados-nación multiculturales: análisis en paralelo de México y Colombia
Authors: Pazos Cardenas Mateo
Published: May 2017

The article analyzes two Latin American afromusic festivals -one in Mexico and one in Colombia-, trying to find the strategies by which the multicultural project is expressed in these historical and culturally different scenarios. Using qualitative techniques, the ways through which the state institutions organizing the events and the people attending them build their experiences mediated by ethno-cultural difference and multicultural legislation that regulates it are characterized. The paper concludes that the Latin American multicultural project presents serious structural flaws in their actions and raises other ways of understanding the ethnic and racial otherness and its relationship to state institutions.
Educación y civismo. Los casos de Pereira y Manizales entre 1925 y 1950
Authors: Rodríguez Caporalli Enrique
Published: May 2017

Reseña del libro:Jhon Jaime Correa (2015). Civismo y educación en Pereira y Manizales (1925-1950). Pereira. Universidad Tecnológica de Pereira.
Evaluación del impacto de la modalidad formativa learning by doing en profesionales sanitarios en Aragón
Authors: Gracia-Pérez María Luisa , Gil-Lacruz Marta , Gil-Lacruz Ana Isabel
Published: May 2017

Los profesionales sanitarios requieren de un proceso formativo constante que les permita hacer frente a retos actuales como: la innovación tecnológica, los nuevos modelos organizacionales, la medicina basada en la evidencia, los cambios epidemiológicos, la participación del usuario, etc. A pesar de los recursos y esfuerzos invertidos, no se ha prestado suficiente atención a la evaluación de la formación de dichos profesionales. Este artículo analiza la evaluación de impacto formativo en base a un programa learning by doing llevado a cabo en el Servicio Aragonés de Salud. En este programa las actividades formativas son propuestas, implementadas y valoradas por los profesionales del servicio en el lugar de trabajo tras un proceso gerencial de selección. Se ha trabajado con una encuesta diseñada de elaboración propia y remitida a los profesionales participantes como alumnos. 182 médicos y enfermeras respondieron on line. Mediante análisis bivariante y regresiones se ha analizado la interacción entre el aprendizaje de conocimientos y habilidades, su trasferencia al lugar del trabajo y la calidad asistencial. En un 94,4% de los encuestados se constata la relación entre la mejora de la competencia profesional (adquisición de conocimientos y habilidades, utilidad para la profesión, aplicación de los conocimientos nuevos y habilidades en el centro de trabajo, formación en cascada y mejora de los conocimientos y las habilidades) y mejora de la calidad asistencial (medida mediante los indicadores del European Foundation for Quality Management). El diseño de la evaluación del impacto formativo debería estar vinculado a las evaluaciones previas y, sus resultados miden los efectos mediatos en la organización. Esta información se convierte en una herramienta clave para valorar la efectividad del programa ejecutado y para la programación de actuaciones futuras, que garanticen la formación continua de los profesionales sanitarios y permitan mejorar la calidad de sus actuaciones.
Assessment of technical requirements for the future spaceborne maritime and airspace surveillance radar
Authors: Grigas S. E. , Litovchenko D. Ts. , Skorynin A. A.
Published: May 2017

Technical requirements for a spaceborne maritime and airspace surveillance synthetic aperture radar are discussed.
PoesiAHA! 1 Ao enfermeiro-criativo
Authors: Silva Onã
Published: May 2017

Poesia dedicada ao Dr. Elioenai Dornelles Alves em reconhecimento ao seu trabalho inovador no campo da enfermagem. Profissional que se destaca pelo trabalho de semear e promover ações criativas no cuidado de enfermagem.
Association of Preventive Maintenance Therapy Compliance and Peri‐Implant Diseases: A Cross‐Sectional Study
Authors: Monje Alberto , Wang Hom‐Lay , Nart José
Published: May 2017

Background: This study aims to investigate association between peri‐implant maintenance therapy (PIMT) and the frequency of peri‐implant diseases and to further identify factors that contribute to failure of PIMT compliance.

Methods: A cross‐sectional study on patients who were healthy and partially edentulous was conducted. They were grouped in the following categories according to PIMT compliance: 1) regular compliers (RC) (≥2 PIMT/year); 2) erratic compliers (EC) (<2 PIMT/year); and 3) non‐compliers (NC) (no PIMT). Radiographic and clinical analyses were carried out including probing depth (PD), plaque index (PI), bleeding on probing (BOP), mucosal redness (MR), suppuration (SUP), keratinized mucosa dimension, and marginal bone loss. A multiple logistic regression model was estimated at implant and patient level to obtain adjusted odds ratios (ORs) and to control possible confounding effects among variables.

Results: Overall, 206 implants in 115 patients fulfilled inclusion criteria. At patient level, it was shown that association between compliance and peri‐implant condition was statistically significant (P = 0.04). Compliance was associated with 86% fewer conditions of peri‐implantitis. The probability of PIMT compliance was substantially associated with frequency of peri‐implantitis (OR = 0.13, P = 0.01). Patients with a history of periodontal disease multiplied their probability of being EC (versus NC) 4.23 times with respect to not having a history of periodontal disease (P = 0.02). Moreover, light smokers significantly resulted to be NC compared with RC (P = 0.04) and EC (P = 0.02). Nevertheless, mucositis was not found to be statistically associated with level of compliance. In addition, PD, PI, BOP, MR, and SUP varied significantly according to PIMT compliance and peri‐implant condition.

Conclusions: Peri‐implant maintenance compliance ≥2 PIMT/year seems to be crucial to prevent peri‐implantitis in healthy patients. Furthermore, history of periodontal disease and disease severity, as well as its extent and a smoking habit, appear to be factors that influence the compliance risk profile (NCT02789306).
Metformin Inhibits Porphyromonasgingivalis Lipopolysaccharide‐Influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor‐3 Expression
Authors: Kang Wenyan , Wang Ting , Hu Zhekai , Liu Feng , Sun Yundong , Ge Shaohua
Published: May 2017

Background: Chronic periodontitis, one of the most prevalent oral diseases, is associated with Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS) infection and has profound effects on type 2 diabetes mellitus (t2DM). Metformin, a well‐known antidiabetic agent, has been reported to exert anti‐inflammatory effects on various cells. This study aims to investigate the role of metformin on LPS‐influenced inflammatory response in human gingival fibroblasts (HGFs).

Methods: Dose‐dependent additive effects of metformin on LPS‐influenced HGFs were detected. Cell‐counting assay was used to determine effects of metformin and LPS on viability of HGFs. Enzyme‐linked immunosorbent assay and quantitative real‐time polymerase chain reaction (qRT‐PCR) were applied to detect levels of interleukin (IL)‐1β, IL‐6, and tumor necrosis factor (TNF)‐α in differently treated cells. Activating transcription factor‐3 (ATF3) small interfering (si)RNA transfection was used to determine the mechanism of metformin action, and the transfection efficiency was observed by fluorescence microscope. Effects of ATF3 knockdown were determined by qRT‐PCR and Western blot.

Results: Results showed that 5 μg/mL Pg LPS and 0.1, 0.5, and 1 mM metformin exhibited no toxicity to HGFs, and metformin inhibited LPS‐influenced IL‐1β, IL‐6, and TNF‐α production in a dose‐dependent manner. Metformin and LPS could synergistically facilitate ATF3 expression, and ATF3 knockdown abolished inhibitory effects of metformin on LPS‐influenced inflammatory cytokine production in HGFs.

Conclusion: The present study confirms that metformin suppresses LPS‐enhanced IL‐6, IL‐1β, and TNF‐α production in HGFs via increasing ATF3 expression.
Analiza toksykologiczna peptydów w materiale biologicznym z wykorzystaniem spektrometrii mas na przykładzie oznaczania alfa-amanityny
Authors: Janus Tomasz , Jasionowicz Ewa , Potocka-Banaś Barbara , Borowiak Krzysztof
Published: May 2017

Wstęp: Rutynowa analiza toksykologiczna materiału biologicznego obejmuje najczęściej badania w kierunku identyfikacji związków o różnym charakterze, właściwościach i budowie organicznej lub nieorganicznej, jednak o masie nieprzekraczającej 500–600 Da. Większość związków organicznych to cząstki o stosunkowo niewielkiej masie. Zupełnie odmienną grupą analityczną są związki o budowie peptydowej i masie przekraczającej 900 Da, będące składnikami wielu toksyn, szczególnie grzybów kapeluszowych czy jadów zwierzęcych. Celem pracy było przedstawienie analitycznej specyfiki związków o strukturze peptydowej na przykładzie alfa-amanityny, oznaczanych w powszechnie stosowanych układach LC-MS/MS, na podstawie badań własnych.Materiały i metody: Materiał badawczy stanowił mocz pobierany od pacjentów w ramach rutynowej diagnostyki zatruć grzybami, analizowany pod kątem obecności alfa-amanityny. Mocz poddany został ultrafiltracji na filtrach wirówkowych o odcięciu masowym 3 kDa; przesącz poddano bezpośredniej analizie chromatograficznej z detekcją mas.Wyniki: Peptydy jako grupa związków organicznych wykazujących właściwości amfoteryczne przy stosunkowo dużej masie cząsteczkowej mogą być ekstrahowane w układzie fazy stałej, jednak na dedykowanych kolumnach. W pracy wykazano, iż zastosowanie ultrafiltracji na etapie przygotowania próbek do analizy pozwala na skuteczną izolację alfa-amanityny, przy zachowaniu wymaganej czułości oznaczenia i ograniczeniu wpływu matrycy na sprawność układu analitycznego. Specyfiką peptydów jest także ich mało charakterystyczna fragmentacja, skutkująca jedynie intensywnym sygnałem o masie M-18 Wykorzystanie tego przejścia masowego w trybie pomiaru MS/MS nie pozwala jednak na uzyskanie całkowicie selektywnego chromatogramu. Zastosowanie wyższych energii kolizyjnych prowadzi do uzyskania bardziej charakterystycznego widma masowego, jednak skutkuje to jednoczesnym spadkiem czułości oznaczenia.Wnioski: Ultrafiltracja jako etap przygotowania próbek w analizie alfa-amanityny jest efektywną metodą izolacji peptydów z matrycy. Monitoring przejścia masowego w trybie MS/MS z utratą cząsteczki wody pozwala na uzyskanie wysokiej czułości oznaczenia.
Występowanie wybranych czynników ryzyka związanych ze specyfiką pracy zawodowych kierowców
Authors: Czerwińska Maja , Hołowko Joanna , Stachowska Ewa
Published: May 2017

Wstęp: Zawód kierowcy należy do grupy obarczonej szczególnie dużym ryzykiem zdrowotnym. Czynniki zwiększające ryzyko zachorowania na choroby cywilizacyjne są ściśle związane z warunkami pracy. Celem pracy była analiza wybranych czynników ryzyka, które związane są ze stylem życia zawodowych kierowców.Materiały: Materiał badawczy stanowiły 23 artykuły zagraniczne i polskie dostępne w bazie PubMed. Wniosek: Z przeanalizowanych artykułów wynika, że zawodowi kierowcy są grupą, w której czynniki związane z warunkami pracy mają znaczący wpływ na stan zdrowia
Przykład znakomitej adaptacji czynnościowej pacjenta po amputacji 4 palców ręki – opis przypadku
Authors: Żyluk Andrzej , Szperka Ewa
Published: May 2017

W pracy przedstawiono przypadek 84-etniego mężczyzny, który w wyniku eksplozji zaraz po II wojnie światowej stracił ͘ palce ręki niedominującej (w tym kciuk). Pomimo znacznego okaleczenia ukończył szkołę, zdał maturę i podjął pracę w zakładach mechanicznych. Z upływem czasu przystosował się doskonale do swojej niepełnej sprawności, wykonując prace w warsztatach mechanicznych oraz uzyskując prawo jazdy na samochód i motocykl. Pracował na pełnym etacie aż do emerytury. Badanie kliniczne okaleczonej ręki wykazało siłę chwytu globalnego 10 kg (͗31% siły zdrowej ręki), dobrą czynność (17 pkt w skali DASH) i ogólną dobrą jakość życia ocenioną kwestionariuszem SF-36 Przedstawiony przypadek jest przykładem ogromnych zdolności przystosowawczych człowieka do kalectwa fizycznego i znacznego potencjału w odzyskiwaniu utraconej sprawności.
Graduate Periodontics Programs’ Integration of Implant Provisionalization in Core Curricula: Implementation of CODA Standard 4–10.2.d
Authors: Barwacz Christopher A. , Pantzlaff Ed , Allareddy Veerasathpurush , Avila-Ortiz Gustavo
Published: May 2017

The aim of this descriptive study was to provide an overview of the status of implementation of Commission on Dental Accreditation (CODA) Standard 4–10.2.d (Provisionalization of Dental Implants) by U.S. graduate periodontics programs since its introduction in 2013. Surveys were sent in May 2015 to 56 accredited postdoctoral periodontics program directors to ascertain program director characteristics; status of planning, implementation, and curriculum resulting from adoption of Standard 4–10.2.d; preferred clinical protocols for implant provisionalization; interdisciplinary educational collaborators; and competency assessment mechanisms. The survey response rate was 52% (N=29); the majority were male, aged 55 or older, and had held their position for less than ten years. Among the responding programs, 93% had formal educational curricula established in implant provisionalization. Graduate periodontics (96%) and prosthodontics (63%) faculty members were predominantly involved with curriculum planning. Of these programs, 96% used immediate implant provisionalization, with direct (chairside) provisionalization protocols (86%) being preferred over indirect protocols (14%) and polyethylethylketone provisional abutments (75%) being preferred to titanium (25%) provisional abutments. Straight and concave transmucosal emergence profile designs (46% each) were preferred in teaching, with only 8% of programs favoring convex transmucosal profiles. A majority of responding programs (67%) lacked protocols for communicating to the restorative referral a mechanism to duplicate the mature peri‐implant mucosal architecture. Regional location did not play a significant role in any educational component related to implant provisionalization for these graduate periodontal programs. Overall, this study found that a clear majority of graduate periodontics programs had established formal curricula related to implant provisionalization, with substantial clinical and philosophical consensus within the specialty.
Using Intervention Mapping to Develop an Oral Health e‐Curriculum for Secondary Prevention of Eating Disorders
Authors: DeBate Rita D. , Bleck Jennifer R. , Raven Jessica , Severson Herb
Published: May 2017

Preventing oral‐systemic health issues relies on evidence‐based interventions across various system‐level target groups. Although the use of theory‐ and evidence‐based approaches has been encouraged in developing oral health behavior change programs, the translation of theoretical constructs and principles to behavior change interventions has not been well described. Based on a series of six systematic steps, Intervention Mapping provides a framework for effective decision making with regard to developing, implementing, and evaluating theory‐ and evidence‐informed, system‐based behavior change programs. This article describes the application of the Intervention Mapping framework to develop the EAT (evaluating, assessing, and treating) evidence‐based intervention with the goal of increasing the capacity of oral health providers to engage in secondary prevention of oral‐systemic issues associated with disordered eating behaviors. Examples of data and deliverables for each step are described. In addition, results from evaluation of the intervention via randomized control trial are described, with statistically significant differences observed in behavioral outcomes in the intervention group with effect sizes ranging from r=0.62 to 0.83. These results suggest that intervention mapping, via the six systematic steps, can be useful as a framework for continued development of preventive interventions.
Partial Ceramic Crowns Prepared by Dental Students: Clinical Performance Up to Five Years
Authors: Bühler Julia , Naef Marina Alena , Amato Mauro , Krastl Gabriel , Weiger Roland , Zitzmann Nicola Ursula
Published: May 2017

Partial ceramic crowns (PCCs) are an accepted treatment option for the restoration of posterior teeth with deficient tooth substance. Data on the survival of PCCs fabricated by dental students are scarce. The aim of this retrospective clinical study was to investigate the clinical performance and longevity of PCCs placed by dental students in the last year of their training program at the University of Basel, Switzerland. Eighty‐eight patients who had received at least one PCC (n=108) in the program were considered for clinical assessment; their records were analyzed to detect previous complications or failures; and they were contacted by telephone. Criteria regarding aesthetic, functional, and biological aspects were rated with a scoring system from 1=clinically excellent to 5=clinically poor. The response rate was 66.3% (55 of 83 included patients), and 72.2% (n=78) of the PCCs were included in the analysis. Five PCCs had been lost within ten to 78 months after treatment. Six PCCs were recorded as failures (score 5), and ten received clinically unsatisfactory gradings (score 4). The risk of a clinically poor outcome was 14% after five years (86% survival), while the overall success rate was 63.5%. These results suggest that the clinical procedure of PCCs was successfully implemented by these students with satisfactory clinical survival.
La versión de “El Sistema” en Costa Rica: Una perspectiva desde la etnografía postcolonial institucional
Authors: Rosabal-Coto Guillermo
Published: May 2017

En este artículo sugiero que el SINEM — la versión costarricense de El Sistema venezolano — articula un discurso de desarrollo que legitima políticas neoliberales que rigen el mercado internacional del siglo XXI, en el cual Costa Rica figura solamente como un subalterno. Planteo que tal articulación contribuye a perpetuar nociones y prácticas que se fundaron en el período colonial y que han sostenido el imaginario de la identidad nacional costarricense desde el siglo XIX. Para demostrarlo, llevo a cabo un análisis teórico por medio de la etnografía postcolonial institucional.
Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD
Authors: Fuhrman Dana Y. , Schneider Michael F. , Dell Katherine M. , Blydt-Hansen Tom D. , Mak Robert , Saland Jeffrey M. , Furth Susan L. , Warady Bradley A. , Moxey-Mims Marva M. , Schwartz George J.
Published: May 2017

Background and objectives

The role of albuminuria as an indicator of progression has not been investigated in children with CKD in the absence of diabetes.

Design, setting, participants, & measurements

Children were enrolled from 49 centers of the CKD in Children study between January of 2005 and March of 2014. Cross-sectional multivariable linear regression (n=647) was used to examine the relationship between urine protein-to-creatinine (UP/C [milligrams per milligram]) and albumin-to-creatinine (ACR [milligrams per gram]) with eGFR (milliliters per minute per 1.73 m2). Parametric time-to-event analysis (n=751) was used to assess the association of UP/C, ACR, and urine nonalbumin-to-creatinine (Unon-alb/cr [milligrams per gram]) on the time to the composite endpoint of initiation of RRT or 50% decline in eGFR.

Results

The median follow-up time was 3.4 years and 202 individuals experienced the event. Participants with a UP/C≥0.2 mg/mg and ACR≥30 mg/g had a mean eGFR that was 16 ml/min per 1.73 m2 lower than those with a UP/C<0.2 mg/mg and ACR<30 mg/g. Individuals with ACR<30 mg/g, but a UP/C≥0.2 mg/mg, had a mean eGFR that was 9.3 ml/min per 1.73 m2 lower than those with a UP/C<0.2 mg/mg and ACR<30 mg/g. When categories of ACR and Unon-alb/cr were created on the basis of clinically meaningful cutoff values of UP/C with the same sample sizes for comparison, the relative times (RTs) to the composite end-point were almost identical when comparing the middle (RT=0.31 for UP/C [0.2–2.0 mg/mg], RT=0.38 for ACR [56–1333 mg/g], RT=0.31 for Unon-alb/cr [118–715 mg/g]) and the highest (RT=0.08 for UP/C [>2.0 mg/mg], RT=0.09 for ACR [>1333 mg/g], RT=0.07 for Unon-alb/cr [>715 mg/g]) levels to the lowest levels. A similar trend was seen when categories were created on the basis of clinically meaningful cutoff values of ACR (<30, 30–300, >300 mg/g).

Conclusions

In children with CKD without diabetes, the utility of an initial UP/C, ACR, and Unon-alb/cr for characterizing progression is similar.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_05_30_Schwartz.mp3
Technical procedures to select basic parameters of a fluxgate magnetometer
Authors: Kabata Wanderli , Vitorello Ícaro
Published: May 2017

In fluxgate magnetometers, the external magnetic field is generally measured from the second harmonic induced voltage in the pick-up coil. Thus, toimprove the performance of a fluxgate magnetometer design, careful considerations should focus on some operational parameters and how to calibrate them to attainan optimal performance with a minimum intrinsic noise at the output. Basically, two main factors are considered: i) the output dependence on variations of the evenharmonics amplitudes with the excitation current; and ii) adjustments for a perfect timely match between the core saturation and the time-width of the sampling. Thebest sensitivity of the magnetometer is obtained in a portion of the hysteresis curve where the 2nd harmonic component predominates. Since this region depends on theamplitude of the excitation, it becomes necessary to calibrate the excitation amplitude in order to get the highest 2nd harmonic amplitude in the pick-up coil. When theamplitude of the excitation current is modified, the amplitude of the even harmonics also changes, and consequently the magnetometer will operate below its optimalsensitivity, depending on how much the current has changed. Similar result is observed when the core is built with a different inductance (different number of wraps)which requires operational tests to be carried out to verify the level of the core saturation by adjusting the amplitude and the frequency to get the best performancefrom the magnetometer. Changes in the amplitudes of the excitation current generally occur with changes in the excitation current waveform, affecting the timing ofthe core saturation. To avoid bad synchronization between the excitation current and the sampling, the phase shift circuit is locked with the excitation current circuitin order to work together and variations on the excitation current phase is automatically corrected in the sampling circuit. In summary, finding the moment whenthe 2nd harmonic has its greatest value, adjusting the time-width of the synchronous detector and avoiding phase’s shifts between excitation and detection circuitscan produce a magnetometer performing at its lowest noise output.
Utilização de métodos geofísicos para mapeamento de lama fluida no porto de tubarão, vitória (ES-Brasil)
Authors: Quaresma Valéria Da S. , Bastos Alex C. , Loureiro Diego V. , Paixão Sandro
Published: May 2017

A ocorrência de depósitos de lama fluida é muito comum em canais de navegação e, por esta razão o mapeamento e a caracterização destes depósitos se tornam cada vez mais importantes para a manutenção da navegabilidade destas áreas. Dessa forma, o objetivo deste trabalho foi de demonstrar a aplicação de métodos acústicos de investigação geofísica na identificação da ocorrência de lamas fluidas e seu mapeamento. Para tanto, foram realizados levantamentos sísmicos, batimétricos, sonográficos e coleta de testemunhos para determinação da sua densidade. Estes levantamentos foram realizados na área do Porto de Tubarão (Espírito Santo) visando fornecer subsídios técnicos para o aprofundamento do seu canal de acesso. A presença da lama fluida foi confirmada pela análise dos registros sonográficos, batimétricos e de sísmica rasa, que exibiram um padrão específico relacionado a este tipo de suspensão com altas concentrações. Os valores de densimetria dos testemunhos também indicaram a presença da lama fluida e a tendência de diferenciação dos sinais acústicos em função da densidade do meio.
Lógica FUZZY e técnica sam para modelagem previsional do ouro no setor oeste da província mineral do tapajós usando dados aerogeofísicos e de sensoriamento remoto
Authors: Carrino Thais Andressa , Silva Adalene Moreira , Botelho Nilson Francisquini , Silva Alexandre Augusto Cardoso da
Published: May 2017

A Província Mineral do Tapajós (PMT) compreende a maior província aurífera do Brasil e localiza-se na parte centro-sul do Cráton Amazônico. A PMT é caracterizada por unidades litoestratigráficas paleoproterozoicas que hospedam mineralizações auríferas de mesma idade. Com base neste potencial mineral, este artigo objetivou o processamento e a modelagem espacial de dados aerogeofísicos regionais (levantamento Bloco I – Província Aurífera do Tapajós) e de  sensoriamento remoto (SAR-R99B e TM/Landsat 5) disponíveis para a geração de mapas de favorabilidade aurífera do setor oeste da PMT. Para tal, imagens da razão K/eTh e do parâmetro F foram produzidas no intuito de se realçar o enriquecimento de K. Imagem de buffers de lineamentos, interpretados através de imagens magnetométricas, SAR-R99B e do sensor TM, foi gerada para a interpretação de componentes estruturais relevantes. Empregando-se estes produtos, além do mapa geológico regional disponibilizado no projeto PROMIN-Tapajós, foi utilizada a técnica lógica fuzzy e o classificador Spectral Angle Mapper objetivando a produção de mapas previsionais de ouro. Ocorrências de ouro atualmente conhecidas foram usadas para a validação dos resultados e uma discussão sobre o desempenho da geração de mapas previsionais regionais em terrenos com baixo conhecimento geológico foi realizada.
Impacto de aterramentos sobre a hidrodinâmica da Baía da Ribeira – Salvador-BA: Uma investigação através de modelagem num´erica
Authors: Franklin Taoan Silva , Lessa Guilherme Camargo
Published: May 2017

A região da Baía da Ribeira abriga cerca de 6% da população do município de Salvador-BA, sendo considerada uma das áreas da cidade com o maior grau de degradação urbana e ambiental. Ao longo dos últimos 50 anos, a ocupação intensa e desordenada desta região avançou sobre as margens da baía, implicando em uma redução de aproximadamente 43% do espelho d’água original e a destruição quase completa das áreas de mangue. Este trabalho investiga, através de modelagem numérica, o efeito desses aterramentos históricos sobre a circulação de água na baía. Os resultados indicam que a redução das dimensões originais da baía afetou significativamente a hidrodinâmica local. Entre 1959 e 2007 houve uma diminuição da ordem de 45% do prisma de maré, que causou uma redução das velocidades de corrente e dos tempos de residência, além de alterar o padrão da circulação residual. As simulações da capacidade de renovação de água mostraram que houve uma redução do tempo para renovação completa do volume de água, o qual passou de 112 para 38 dias no canal de entrada, e de 175 para 42 dias na área mais interna. Desta forma, é provável que o atual grau de degradação das águas da Baía da Ribeira tenha maior relação com o volume de poluentes descartados no seu corpo d’água do que necessariamente com o processo de aterro ocorrido ao longo das últimas décadas.
MODAL INVERSION BY USING PARAMETERIZATION WITH CHEBYSHEV POLYNOMIALS
Authors: Marin Fernando De Oliveira , Rodríguez Orlando Camargo , Guimarães Luiz Gallisa , Ribeiro Carlos Eduardo Parente
Published: May 2017

ABSTRACT. This paper discusses the estimation of sound speed perturbations in a shallow water waveguide, from measurements of modal travel times. The formulation of the Inverse Problem is reduced to a least squares solution, being highlighted that the choice of discretization of the set of model parameters is of fundamental importance. In the...Keywords: shallow water, tomography, orthogonal functions. RESUMO. Este trabalho aborda a estimativa de perturbações de velocidade do som em um ambiente de águas rasas, a partir de medições de tempo de percurso modal. A formulação do Problema Inverso é reduzida a uma solução por mínimos quadrados, sendo destacado que a escolha da discretização do conjunto de parâmetros do modelo é de fundamental...Palavras-chave: águas rasas, tomografia, funções ortogonais.
Los comuneros, el abogado y el senador. Cultura política y orden liberal a fines del porfiriato
Authors: Rangel Silva José Alfredo
Published: May 2017

En 1906 los “cabezas de familia” de cinco comunidades indígenas le pidieron al abogado Wistano Luis Orozco que los representara en sus pleitos legales por la defensa de sus tierras. Parte de la estrategia legal fue escribir un memorial de los agravios experimentados y dirigirlo a Porfirio Díaz. El memorial y el proceso judicial que desencadenó ejemplifican cómo los actores sociales daban forma a la cultura política en los ámbitos locales, estatales y nacionales, a finales del porfiriato.
Sobre José Armando Hernández Soubervielle, De piedra y de maíz. Las alhóndigas y el abastecimiento de granos en San Luis Potosí durante el virreinato
Authors: Calvo Thomas
Published: May 2017

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Sobre Cristina V. Masferrer León, Muleke, negritas y mulatillos. Niñez, familia y redes sociales de los esclavos de origen africano en la ciudad de México, siglo XVII
Authors: Nava Román Rosario
Published: May 2017

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Sobre Lourdes Turrent, Rito, música y poder en la Catedral Metropolitana, México, 1790-1810
Authors: Connaughton Brian
Published: May 2017

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Sobre Ben Fallaw y Terry Rugeley (eds.), Forced marches. Soldiers and military caciques in modern Mexico
Authors: José Valenzuela Georgette
Published: May 2017

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La política agraria en el Yucatán colonial: las composiciones de tierras en 1679 y 1710
Authors: Carrera Quezada Sergio Eduardo
Published: May 2017

Este artículo aborda un tema poco atendido en la historiografía yucateca: la concesión de los bienes realengos y el programa de composiciones de tierras durante el periodo colonial. Analiza los motivos por los cuales los españoles casi no aprovecharon la entrega gratuita de mercedes para formar sus estancias de ganado, y en cambio prefirieron comprar tierras, pozos y cenotes a los caciques y los miembros de los linajes mayas. También se muestran las características que adquirió el programa de composiciones en esta región, como lo fue su tardía aplicación, las negociaciones entre los dueños de las estancias y los jueces de comisión, y el beneficio exclusivo para el grupo español. Por último se expone de qué forma los mayas yucatecos emprendieron diversas estrategias para defender sus derechos a la posesión inmemorial de sus tierras.
Sobre Valentina Garza Martínez y Juan Manuel Pérez Zevallos (eds.), Las visitas pastorales de Mazapil, 1572-1856
Authors: López Castillo Gilberto
Published: May 2017

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Sobre Carolina González Undurranga, Esclavos y esclavas demandando justicia. Chile, 1740-1823. Documentación judicial por carta de libertad y papel de venta
Authors: Albornoz Vásquez María Eugenia
Published: May 2017

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Sobre María Victoria Crespo, Del rey al presidente (Poder Ejecutivo, formación del Estado y soberanía en la Hispanoamérica revolucionaria, 1810-1826)
Authors: Breña Roberto
Published: May 2017

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Sobre Ana Rosa Suárez, El camino de Tehuantepec. De la visión a la quiebra (1854-1861)
Authors: Jiménez Marce Rogelio
Published: May 2017

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Sobre Carlos Illades y Teresa Santiago, Estado de guerra. De la guerra sucia a la narcoguerra
Authors: Kent Carrasco Daniel
Published: May 2017

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La tentación monárquica de Alberdi
Authors: Crespo Horacio
Published: May 2017

El artículo revisa el libro de Alberdi Del gobierno de Sud-América según las miras de su revolución fundamental, escrito entre 1863 y 1867 –cuando se imponía la monarquía en México y se suponía que varios países de Sudamérica podrían seguir el mismo camino– y publicado en forma póstuma en 1896. En ese polémico texto, el autor de Bases discute la conveniencia y adecuación de la monarquía a las condiciones necesarias para el progreso de la América hispánica y muestra una preferencia, ambigua, por las formas de la monarquía constitucional sobre la república, siendo éste el elemento más provocativo de todas las reflexiones contenidas en el libro. En la síntesis última, Alberdi se expresa a favor de la república centralista, con un poder afianzado y al servicio del desarrollo civilizatorio.
El bestiario del empiorador. Notas sobre la caricatura republicana durante la Intervención y el Segundo Imperio
Authors: Torre Hernández Alejandro de la
Published: May 2017

Este artículo explora algunas de las más significativas expresiones de la caricatura republicana durante la época de la Intervención francesa y el Segundo Imperio. Pone particular atención a las representaciones de monstruos y criaturas zoomorfas que habitaban el imaginario de la sátira política de mediados del siglo XIX, analizando los usos de la imagen como elementos cruciales de la propaganda, la lucha política y la confrontación de proyectos de nación. Así, el artículo propone un recorrido iconográfico por una singular galería de deformidades que fungían como retratos bufos  de la escena política y de la sociedad, a la vez que exponían un enjuiciamiento moral de la convulsa situación nacional.
Algunos ejemplos de criptografía militar mexicana (1860-1879)
Authors: Narváez Roberto
Published: May 2017

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Sobre Jaime M. Pensado, Rebel Mexico. Student Unrest and Authoritarian Political Culture during the Long Sixties
Authors: Sánchez Michel Valeria
Published: May 2017

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