bluuebunny/crossref_metadata_2025 huggingface dataset:
Статистическое тестирование равномерности дискретного распределения вероятностей на основе энтропии Тсаллиса
Authors: Palukha Uladzimir Yuryevich , Kharin Yurii Semenovich
Published: November 2024

В статье рассматриваются задачи построения статистических критериев проверки $s$-мерной равномерности двоичной случайной последовательности на основе энтропии Тсаллиса для двух вариантов задания нулевой гипотезы: простой и сложной. В асимптотике растущей размерности мощности алфавита построены асимптотически несмещенные статистические оценки энтропии Тсаллиса в случаях простой и сложной нулевых гипотез. На основе построенных оценок и их асимптотических распределений построены статистические критерии $s$-мерной равномерности заданного асимптотического размера. Приводятся результаты компьютерных экспериментов.
Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy
Authors: Wen Xue , Qi Lu-Ming , Zhao Kui
Published: November 2024

The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the gut microbiome a new potential therapeutic focus. This commentary examines the recent publication in World Journal of Diabetes . The article explores the association between T2DM and gut microbiota, with a focus on the pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such approaches. This editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic axis. It provides new insights for future research on gut-microbiota-based interventions for T2DM.
Efficacy, safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart: A pilot study
Authors: Yang Na , Lv Lu , Han Shu-Meng , He Li-Yun , Li Zi-Yi , Yang Yu-Cheng , Ping Fan , Xu Ling-Ling , Li Wei , Zhang Hua-Bing , Li Yu-Xiu
Published: November 2024

BACKGROUND

There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin deglu-dec/aspart (IDegAsp) therapy, with insufficient data from the Chinese popu-lation.

AIM

To demonstrate the efficacy, safety, and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus (T2DM).

METHODS

In this 12-week open-label, non-randomized, single-center, pilot study, patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin IDegAsp. Insulin doses, hemoglobin A1c (HbA1c) levels, fasting blood glucose (FBG), hypoglycemic events, a Diabetes Treatment Satisfaction Questionnaire, and other parameters were assessed at baseline and 12-weeks.

RESULTS

This study included 21 participants. A marked enhancement was observed in the FBG level (P = 0.02), daily total insulin dose (P = 0.03), and overall diabetes treatment satisfaction (P < 0.01) in the participants who switched to IDegAsp. There was a decrease in HbA1c levels (7.6 ± 1.1 vs 7.4 ± 0.9, P = 0.31) and the frequency of hypoglycemic events of those who switched to IDegAsp decreased, however, there was no statistically significant difference.

CONCLUSION

The present findings suggest that treatment with IDegAsp enhances clinical outcomes, particularly FBG levels, daily cumulative insulin dose, and overall satisfaction with diabetes treatment.
Diabetes-inducing effects of bronchial asthma
Authors: Al-Beltagi Mohammed , Bediwy Adel Salah , Saeed Nermin Kamal , Bediwy Hosameldin A , Elbeltagi Reem
Published: November 2024

BACKGROUND

The relationship between diabetes mellitus (DM) and asthma is complex and can impact disease trajectories.

AIM

To explore the bidirectional influences between the two conditions on clinical outcomes and disease control.

METHODS

We systematically reviewed the literature on the relationship between DM and asthma, focusing on their impacts, mechanisms, and therapeutic implications. Various studies were assessed, which investigated the effect of glycemic control on asthma outcomes, lung function, and exacerbations. The study highlighted the role of specific diabetes medications in managing asthma.

RESULTS

The results showed that poor glycemic control in diabetes can exacerbate asthma, increase hospitalizations, and reduce lung function. Conversely, severe asthma, especially in obese individuals, can complicate diabetes management and make glycemic control more difficult. The diabetes-associated mechanisms, such as inflammation, microangiopathy, and oxidative stress, can exacerbate asthma and decrease lung function. Some diabetes medications exhibit anti-inflammatory effects that show promise in mitigating asthma exacerbations.

CONCLUSION

The complex interrelationship between diabetes and asthma suggests bidirectional influences that affect disease course and outcomes. Inflammation and microvascular complications associated with diabetes may worsen asthma outcomes, while asthma severity, especially in obese individuals, complicates diabetes control. However, the current research has limitations, and more diverse longitudinal studies are required to establish causal relationships and identify effective treatment strategies for individuals with both conditions.
Unveiling mitochondrial mysteries: Exploring novel tRNA variants in type 2 diabetes mellitus
Authors: Cheng Chun-Han , Hao Wen-Rui , Cheng Tzu-Hurng
Published: November 2024

The recent study of Ding et al provides valuable insights into the functional implications of novel mitochondrial tRNATrp and tRNASer(AGY) variants in type 2 diabetes mellitus (T2DM). This editorial explores their findings, highlighting the role of mitochondrial dysfunction in the pathogenesis of T2DM. By examining the molecular mechanisms through which these tRNA variants contribute to disease progression, the study introduces new targets for therapeutic strategies. We discuss the broader implications of these results, emphasizing the importance of understanding mitochondrial genetics in addressing T2DM.
Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies
Authors: Du Jia-Yi , Zhang Chu-Ting , Li Ting , Li Ya-Ping
Published: November 2024

In this manuscript we comment on the article by Yang et al published recently, focusing on how hepatic angiopoietin-2 (Ang-2) transcription promote the progression of hepatocellular carcinoma (HCC). HCC is one of the most common and lethal malignancies worldwide, especially in regions with high hepatitis B virus infection rates. Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC, particularly in the hypoxic microenvironment. This paper reviews the dynamic expression of Ang-2 in hepatocarcinogenesis and its regulation by hypoxia-inducible factor-1α. Furthermore, we discuss Ang-2’s potential as an early monitoring biomarker for metastasis, and the therapeutic prospects of silencing hypoxia-inducible factor-1α to downregulate Ang-2 and suppress epithelial-mesenchymal transition in HCC treatment.
Clinical analysis of Klebsiella pneumoniae infection in patients with liver cirrhosis in Beijing
Authors: Zhang Yu , Zhao Hong , Ji Shi-Bo , Xing Hui-Chun
Published: November 2024

BACKGROUND

The incidence of Klebsiella pneumoniae (K. pneumoniae ) infection in patients with cirrhosis has been increasing over recent years, posing certain difficulties in clinical treatment.

AIM

To analyze the clinical features of patients with liver cirrhosis and identify the risk factors to help the early diagnosis and treatment of these diseases.

METHODS

Clinical data and laboratory tests were collected from 72 patients with cirrhosis confirmed by secretion or blood culture of K. pneumoniae infection at Beijing Ditan Hospital, Capital Medical University, between May 2016 and October 2018. Data from hospitalized patients with liver cirrhosis and K. pneumoniae infections, including age, sex, antimicrobial use, length of stay, site of infection, distribution of pathogenic bacteria, complications, invasive operations, laboratory indicators, treatment, and clinical regression, were extracted and retrospectively analyzed. Clinical data and biochemical values were included in the multivariate logistic regression analysis.

RESULTS

A total of 52 men and 20 women, with an age range from 29 to 85 years and an average age of 57.7 ± 12.54, were analyzed. The incidence of hospital K. pneumoniae infection in patients with cirrhosis was approximately 19.44%. The most common the infection site was the bloodstream, followed by the respiratory tract, abdominal cavity, and biliary tract. Risk factors for infection were old age, long hospital stays, gastrointestinal bleeding, and low serum albumin levels, while prophylactic antibiotics were protective factors. The multivariate analysis suggested that other infections, chronic diseases, and invasive procedures were independent factors.

CONCLUSION

In clinical practice, the length of hospital stays should be shortened as much as possible, invasive operations should be reduced, antibiotics should be rationally used, and the patients’ liver function should be timely improved. This is of great significance for reducing the incidence of hospital infection.
Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma
Authors: Yang Jun-Ling , Yang Jie , Fang Rong-Fei , Sai Wen-Li , Yao Deng-Fu , Yao Min
Published: November 2024

BACKGROUND

Angiopoietin-2 (Ang-2) level is related to hepatocellular carcinoma (HCC) progression. However, the dynamic expression and regulatory mechanism of Ang-2 remain unclear.

AIM

To investigate Ang-2 levels in chronic liver diseases and validate early monitoring value with a dynamic model in hepatocarcinogenesis.

METHODS

Sprague-Dawley rats in hepatocarcinogenesis were induced with diet 2-fluorenylacet-amide, and grouped based on liver histopathology by hematoxylin and eosin staining. Differently expressed genes or Ang-2 mRNA in livers were analyzed by whole-genome microarray. Ang-2 levels in chronic liver diseases were detected by an enzyme-linked immunosorbent assay.

RESULTS

Clinical observation reveled that the circulating levels of Ang-2 and hypoxia-inducible factor-1α (HIF-1α) in patients with chronic liver diseases were progressively increased from benign to HCC (P < 0.001). Dynamic model validated that the up-regulated Ang-2 in liver and blood was positively correlated with HIF-1α in hepatocarcinogenesis (P < 0.001). Mechanistically, Ang-2 was regulated by HIF-1α. When specific HIF-1α- microRNAs transfected into HCC cells, the cell proliferation significantly inhibited, HIF-1α and Ang-2 down-regulated, and also affected epithelial-mesenchymal transition via increasing E-cadherin to block cell invasion or migration with reducing of snail, twist and vimentin.

CONCLUSION

Hypoxia-induced Ang-2 up-regulating expression might serve as a sensitive early monitoring biomarker for hepatocarcinogenesis or HCC metastasis.
Multiple intrahepatic artery aneurysms during the treatment for IgG4-related sclerosing cholangitis: A case report
Authors: Tamura Hotaka , Ozono Yoshinori , Uchida Keisuke , Uchiyama Naomi , Hatada Hiroshi , Ogawa Souichiro , Iwakiri Hisayoshi , Kawakami Hiroshi
Published: November 2024

BACKGROUND

The purpose of this case report is to describe a case of multiple intrahepatic artery aneurysms during treatment for IgG4-related sclerosing cholangitis (IgG4-SC) and to provide information for daily practice.

CASE SUMMARY

A 64-year-old Japanese woman was diagnosed with IgG4-SC five years prior and was receiving maintenance treatment with prednisolone 7.5-10 mg/day. She developed abdominal pain and a sudden onset of black stool and was admitted to our hospital. Abdominal contrast-enhanced computed tomography (CT) and ultrasonography (US) revealed multiple intrahepatic artery aneurysms that developed during the treatment for IgG4-SC. Emergency transarterial embolization for multiple hepatic artery aneurysms was performed. Hepatic artery aneurysms disappeared on contrast-enhanced CT and US, the progression of anemia ceased, and the melena resolved. Thus, hemostasis was achieved.

CONCLUSION

Hepatic artery aneurysms should be considered poor prognostic complications of IgG4-SC.
Diversité et abondance de la faune d’insectes de la laitue dans le Centre-Ouest de la Côte d’Ivoire
Authors: Diabate S. , Fondio D. , Sib O. , Appo Yao K.A.P. , Soro S.
Published: November 2024

La laitue, Lactuca sativa (Asteraceae), est un légume-feuille essentiel à la santé humaine, notamment dans les zones urbaines et périurbaines. Cependant, sa production est limitée par divers facteurs, dont l’impact des insectes. Cette étude vise à documenter la diversité et l’abondance de l’entomofaune associée à la culture de la laitue en Côte d’Ivoire. Elle a été réalisée en octobre 2023, pendant la saison des pluies, à Daloa, en utilisant des pièges jaunes et des filets fauchoirs. Au total, 980 insectes ont été capturés, répartis en 63 genres, 52 familles et 9 ordres. Les Diptères ont été les plus abondants (46 %), suivis par les Chrysomelidae (27 %), dominés par Cerotoma sp. avec 264 individus. Les défoliateurs, principalement de la famille des Chrysomelidae, ont été les nombreux dans les cultures. Les insectes bénéfiques des ordres des Hyménoptères, Coléoptères, Diptères et Odonates ont été moins représentés.Les indices de diversité de Shannon (H’ = 1,47) et d’équitabilité (E = 0,51) ont été plus élevés pour les Diptères, tandis que les Dermaptères ont présenté l’indice de diversité le plus bas (H’= 0,03). L’indice de Simpson, bien que similaire pour tous les ordres, a été légèrement inférieur pour les Coléoptères (0,92). Cette étude offre un inventaire préliminaire des insectes associés à la culture de la laitue, fournissant une base pour de futures recherches.
Utilisation of charge transfer complexation reactions for the quantification of antifungal drug: Voriconazol in pure and dosage forms
Authors: A. El-Korashy Sabry , S. Amin Alaa , A. Gouda Ayman , Kh. Alshuwaili Mustafa , E. Ibrahim Hoyeda
Published: November 2024

Voriconazole, a pivotal antifungal agent, has been analysed using two uncomplicated, sensitive, rapid, and validated spectrophotometric methods. These procedures rely on the formation of charge transfer complexes in methanol, employing alizarin red S and quinalizarin as chromogenic reagents, each exhibiting absorption maxima at 568 and 513 nm, respectively. The optimisation of reaction conditions was explored, encompassing the choice of solvent, reagent concentration, and reaction duration. Both alizarin red S and quinalizarin demonstrated excellent adherence to Beer's law over concentration ranges of 1.0-18 and 1.0-24 µg mL-1, respectively, with robust correlation coefficients (r2 ≥ 0.9993) and minimal relative standard deviations (RSD% ≤ 1.04). Additionally, calculations were conducted for molar absorptivity (1.1256×104 and 1.7624 ×104 L mol-1 cm-1), Sandell sensitivity (31.0 and 19.82 ng cm-2), detection and quantification limits (0.3 and 1.0 µg mL-1) for alizarin red S and quinalizarin, respectively. Both methods were effectively applied for the determination of voriconazole in dosage forms, and their validity was confirmed using the standard addition technique. The results obtained from these proposed procedures for pure and dosage forms closely matched those from previously reported methods.
KEY WORDS: Voriconazole, Spectrophotometry, Charge transfer complex, Dosage forms, Method validation.
Bull. Chem. Soc. Ethiop. 2025, 39(2), 189-200.                                                             
DOI: https://dx.doi.org/10.4314/bcse.v39i2.1
Uncovering benzoquinone derivatives for redox flow batteries: DFT insights on reduction potentials and solvent effects
Authors: Abera Negesse Getachew , Diro Chaka Mesfin , Nigatu Gemechu Desalegn , Sakata Gurmesa Gamachis , Abebayehu Desta Mekonnen , Mustefa Mohammed Ahmed , Setarge Mekonnen Yedilfana
Published: November 2024

Quinones possess high redox potential, making them suitable for organic redox-flow batteries. Their oxidation and discharge during charging involve two reversible electron transfer reactions. This study utilized density functional theory (DFT) with the B3LYP functional and 6-31G(d) basis set to calculate the first and second reduction potentials of benzoquinones (BQ). Various BQ derivatives were created by adding electron-donating substituents (-NHCH3, -NH2, -OCH3, -NHCOCH3, -OCOCH3). The universal solvation model (SMD) assessed solvent effects, while lithium salts, solvation-free energy, and HOMO-LUMO energies influenced reduction potentials. The -OCOCH₃-substituted BQ showed the highest first and second redox potentials at 2.81 V and 2.27 V, respectively. Adding boron trifluoride (BF3) salt increased these potentials to 3.99 V and 3.84 V. The electrochemical behavior of BQ and its derivatives was examined in three solvents: carbon tetrachloride (CCl₄), acetonitrile (ACN), and water (H₂O). The average reduction potentials in these solvents followed the trend CCl₄ < ACN < H₂O, with water being the most effective due to its hydrogen bonding and polarity. These findings highlight the significant impact of solvent characteristics on electrochemical processes.
KEYWORDs: Benzoquinone derivatives, DFT, Electron affinity, Reduction potential, Redox flow battery, Solvation-free energy, SMD solvation model
Bull. Chem. Soc. Ethiop. 2025, 39(2), 381-396.                                                                
DOI: https://dx.doi.org/10.4314/bcse.v39i2.15
Evaluation of the greenness profiles of indirect spectrophotometric methods for estimation of gemifloxacin mesylate in pure and dosage forms utilizing N-bromosuccinimide as a green reagent
Authors: Sh. Alenezi Samya , A. Gouda Ayman , El Sheikh Ragaa , El Sayed Ahmed , S. Mahmoud Moataz , F. Abdel Allem Ahmed , O. Babalghith Ahmad , MA Salem Osama
Published: November 2024

A validated, sensitive, user-friendly, precise, and dependable spectrophotometric technique has been developed to accurately detect the concentration of gemifloxacin mesylate in pure and dosage forms. The methods utilize N-bromosuccinimide as an eco-friendly oxidizing agent in acidic circumstances. The residual N-bromosuccinimide is measured by subjecting it to a chemical reaction with preset amounts of dyes, amaranth, methylene blue, and indigocarmine and the absorbance is measured at λmax of 520, 664 and 610 nm, respectively. The analytical technique was implemented and validated by thoroughly examining and optimizing various factors that could potentially disrupt the reaction. Significant linear relationships, characterized by correlation coefficients ranging from 0.9993 to 0.9996, were observed under optimal conditions. These associations remained consistent throughout concentration ranges of 1.0-18, 1.0-14, and 1.0-20 µg/mL. The limits of detection (LOD) of 0.30, 0.29, and 0.30 µg/mL for amaranth, methylene blue, and indigocarmine methods, respectively. The accuracy and precision of the approaches' have been evaluated. No significant interference was observed with the usual pill excipients. In addition, the environmental impact of the suggested processes was assessed using three evaluation tools specifically designed to measure environmental friendliness: the Analytical Greenness Metric, the Green Analytical Procedure Index and Analytical Eco-Scale.
KEY WORDS: Gemifloxacin mesylate, N-bromosuccinimide, Spectrophotometry, Method validation, Dosage forms, Greenness assessment tools.
Bull. Chem. Soc. Ethiop. 2025, 39(2), 227-242.                                                                
DOI: https://dx.doi.org/10.4314/bcse.v39i2.4
Levels of selected toxic heavy metals in the root of Rumex abyssinicus, a traditional medicinal plant, collected from two locations in the city of Addis Ababa
Authors: Mekuanint Yemariam , Gemechu Tura , Megersa Negussie
Published: November 2024

In this study, the contents of selected heavy metals; Fe, Cu, Zn, Cd, Cr, Pb and Ni in the root of Rumex abyssinicus (RA) were determined by flame atomic absorption spectroscopy (FAAS) after acid digestion. The digestion required 3:1 HNO3/HCl (v/v) for 3 h, with temperature of 300°C for complete digestion of 0.5 g RA roots using Kjeldahl apparatus. The levels of metals; Fe, Zn, Cu and Ni were 31.9, 7.76 and 4.73 mg kg-1, respectively, for the samples collected from Addis Ababa University, AAU, Science campus (RA-A samples), and 5.59 Zn, 103 Fe and 3.01 Ni, all in mg kg-1, were found in RA-W sample from Weregenu/Gerji area in AA. Validity of the optimized procedure was evaluated using spiked sample whose recovery varied from 89.8-95.1%. The findings confirmed that only Fe was higher than the tolerance limits. From the health risk perspective, the hazard quotient (HQ) value of Fe for both RA-A and RA-W samples exceeded 1, indicating potential health risks. The hazard index (HI) value suggested that consumption of the root of RA-A and RA-W samples could pose potential health risks over long-term consumption. This may signify the non-carcinogenic health risk associated with consuming RA plant, though continuous regulatory control may necessitate to ensure safety to the consumers.
KEYWORDS: Medicinal plant, Wet digestion, Rumex abyssinicus, Trace metals, Health risk assessment, Pearson correlation.
Bull. Chem. Soc. Ethiop. 2025, 39(2), 243-256.                                                              
DOI: https://dx.doi.org/10.4314/bcse.v39i2.5
Concomitant spontaneous hemothorax and perinephric hematoma: rare presentation of Renal cell carcinoma
Authors: Legesse Tesfaye Kebede , Issa Semira Abrar
Published: November 2024

Spontaneous hemothorax and perinephric hematoma are rare presentations of renal cell carcinoma. We present the case of a 30-year-old female who presented with progressive fatigue and weight loss over a 2-month period. Initially, she was suspected to have empyema and received anti-tuberculosis therapy at a local hospital. However, further evaluation revealed a low hemoglobin level and a CT scan showed a right renal mass with lung metastasis, along with massive hemothorax, perinephric, and retroperitoneal hemorrhage. She underwent surgical management with radical nephrectomy and evacuation of the hematoma. Pathological examination of the surgical specimen confirmed renal cell carcinoma. After treatment, the patient was discharged in stable clinical condition.
Duplex Doppler assessment of portal vein congestive index in asymptomatic hepatitis B virus infected patients in a resource limited set-up: a case-control study
Authors: Momodu H. , Aiyekomogbon J.O. , Itanyi U.D. , Olatunji O.O. , Kolade-Yunusa H.O.
Published: November 2024

Background: A good number of patients with viral hepatitis are asymptomatic and detected as incidental findings. Early detection of the hemodynamic changes as well as prompt treatment is paramount to prevent the development of complications such as portal hypertension, liver cirrhosis and hepatocellular carcinoma. The congestive index (CI) of the portal vein has a high sensitivity and specificity in the diagnosis of hepatic fibrosis and portal hypertension and it is therefore imperative to assess these categories of patients using this index. The objective of this study is to compare the portal vein CI of patients with asymptomatic hepatitis B viral infection and normal individuals"Methods and Patients : This is an institution-based case-control study comprising 112 cases with serological diagnosis of hepatitis B viral infection and 112 age and sex-matched controls that were seronegative for hepatitis B and C viral infection and had normal LFT parameters. The CI of the participants were obtained using duplex Doppler ultrasound, and the data obtained were analyzed using statistical package for social sciences (IBM SPSS version 23.0. Armonk, NY).Result: 224 participants made of 112 cases and 112 age and sex-matched controls were evaluated. The age of the participants ranged from 18-63 years. 113 (50.4%) of the participants were males, while 111 (49.6%) were females. The mean value of the portal vein CI was 0.04±0.003cmS among controls and 0.06±0.01cmS among cases; however, the difference was not statistically significant (p 0.192). CI was noted to increase with age and was higher among the male gender, but the difference was also not significant statistically. Also, LFT parameters among the participants was higher in cases than the control and most were statistically significant except for ALP andAST.Conclusion: The CI of the portal vein and LFT parameters were higher in cases than control and and it may therefore be a useful tool in the assessment of patients with hepatitis, particularly in symptomatic cases.
Lutte contre le tribalisme
Authors: Bubu Kangunza Papy , Makukila Kihosambuta Garry , Mulopo Pemba Herman
Published: November 2024

La République Démocratique du Congo, 62ans après son indépendance en 1960 connait au cours de son processus historique beaucoup de difficultés pour son développement. Au nombre de celles-ci figurent la corruption, l’injustice, le tribalisme. Ces maux et tant d’autres encore constituent le lot des problèmes qui ont plongé l’Etat congolais dans l’incapacité d’assumer ses fonctions régaliennes remettant ainsi en cause le constitutionnalisme qui le fonde.
Dans l’exercice de l’Etat, le tribalisme est une bombe destructrice à la stabilité de l’Etat et du tissu socio-économique du pays. Dans ce sens qu’il ouvre la voie à des luttes incessantes et stériles qui étouffent aussi bien l’esprit, les énergies, la cohésion qui pourtant sont des éléments important pour le pays. A y regarder de près, il ne s’agit pas d’une simple pratique, mais plutôt d’une culture du nivellement par le bas érigée dans cette étude en théorie explicative de la quotidienneté vécue à travers la RDC.
Ainsi, la lutte contre le tribalisme est inévitable. Entant que chercheurs, nous ne pouvons pas garder silence au risque de trahir notre rôle à savoir : éclairer la société. Ce qui requiert un regard pointillé de tout intellectuel sur les questions importantes du fonctionnement de la République.
L’infertilité dans les couples hétérosexuels à Kinshasa
Authors: Musenge Mwanza Gauthier
Published: November 2024

Cet article porte sur la « gestion » et le « traitement » de l’infertilité des couples hétérosexuels dans la société kinoise ; des couples qui, avant de constater des difficultés à concevoir, semblaient réunir toutes les conditions biologiques et sociales d’une entrée en parentalité « dans les normes ». Mais avec le temps, l’échec du projet de grossesse les place hors des normes psychosociales de la procréation, d’entrée en parentalité et de genre.
Les enquêtes menées à Kinshasa montrent que la gestion intime, sociale et médicale des premières années d’infertilité fait apparaître une nette tendance pour les femmes victimes à multiplier les actions de toute nature pour accélérer la concrétisation du projet de grossesse et surtout pour se conformer aux normes sociales. Par contre, pour les hommes, l’expérience de l’infertilité et, en particulier, de l’infertilité masculine, est nettement taboue et donc peu dicible.
Franciszek Kostrzewski, warszawska publiczność i Helena Modrzejewska
Authors: Maresz Barbara
Published: November 2024

The article describes a little-known collage documenting the huge success of Helena Modrzejewska’s first guest performances in Warsaw in October and November of 1868. The author of the Benefis Heleny Modrzejewskiej (a collage kept in the collection of the National Museum in Warsaw) is Franciszek Kostrzewski. This excellent cartoonist and “pencil humorist” presented a triumphant procession of the actress’ admirers. He used a then fashionable technique of combining satirical drawings with pasted fragments of photographs. The participants of the ceremonial procession include mainly representatives of the Warsaw press and theatre scene. The author of the article tried to decipher the people portrayed. She managed to identify and describe nearly 30 people who participated in this extraordinary event, which was Modrzejewska’s Warsaw debut.
Bohater i jego muzeum… Jan Matejko
Authors: Kłak-Ambrożkiewicz Marta
Published: November 2024

The article considers the following issues: the civic attitudes of nineteenth-century society in face of the need to commemorate an outstanding artist; the participation of artists in creating such attitudes; and ways of promoting the nation’s history and culture. The issues are presented in the context of the development of museology in Poland. The text is a case study of the biographical museum in Jan Matejko’s house, opened on 6 March 1898 and since then, through a permanent exhibition and numerous temporary exhibitions, popularising various aspects of artist’s life and work, as well as presenting his rich collections of crafts, textiles and military memorabilia.
Rydlówka jako pozytywne miejsce pamięci
Authors: Zdebska-Schmidt Joanna , Radecka Ewelina
Published: November 2024

Referring to the concept of a memorial site by Pierre Nora, the text presents the functions and activities of Rydlówka – a branch of the Museum of Cracow. It presents Rydlówka in both historical and contemporary context, as an important place for the local and supra-local community, referring to a positive memory. By presenting the activities and the most important elements of the educational program, the authors try to showcase how history, memory and identity intertwine in Rydlówka.
Cognitive development of preschoolers through customized teaching strategies
Authors: BOGHEAN Teodora
Published: November 2024

We live in a society that is constantly changing, that modernizes and develops from one day to the next. These changes appear and modify the usual course of things, however, each new element comes with a beautiful baggage of knowledge and materials that make the didactic activity more special, and the children manage to develop from all points of view and more and more what`s more. Child-centeredness is an extraordinary alternative, which nowadays is used and helps every student to develop harmoniously. In this paper I will focus on cognitive development, on elements that appear in its realization, but also on modern didactic methods which help both parts of learning, more specifically, the teacher and the student.
Innovative technologies for training ecological culture in primary classes
Authors: CHIRIAC Elena
Published: November 2024

The article explores how innovative technologies can be integrated into primary education to develop a strong environmental culture among students. Through interactive educational games, STE(A)M projects and resource monitoring apps, children can learn about the importance of protecting the environment in an engaging and interactive way. These strategies provide personalized learning opportunities, encouraging students to become more aware and responsible for resource conservation and environmental protection. Thus, the conditions are created for the formation of a new generation of citizens with an ecological vision and responsible action.
Senior SOS: Sistem za detekciju pada
Authors:   University of Niš, Faculty of Electronic Engineering, Niš Serbia, Emić Haris , Necin Marko ,   University of Niš, Faculty of Electronic Engineering, Niš Serbia, Petrović Dušan ,   University of Niš, Faculty of Electronic Engineering, Niš Serbia
Published: November 2024

U radu je opisan rad uređaja Senior SOS koji je zamišljen kao pomoć starijim osobama u slučaju pada, kada je potrebno uputiti poziv za pomoć. Pad se detektuje putem senzora, pa se poziv upućuje automatski, jer osoba pri padu može biti i bez svesti.
Loyalty Dilemma: Challenges and Opportunities of Dual Citizenship Policy for the Indonesian Diaspora
Authors: Setio Wardoyo Chris , Eliasta Meliala Adrianus
Published: November 2024

The issue of loyalty and the potential of dual citizenship policies for the Indonesian diaspora, especially the generation of students in the 1960s, is a major concern in the context of state and diaspora relations. This research aims to explore the dynamics of transnational identity, the challenges of a single citizenship policy, and the potential contribution of the diaspora to national development. Using a qualitative approach through in-depth interviews and document analysis, this research explores the perspectives of the Indonesian diaspora regarding the limitations of their citizenship status and the potential of dual citizenship policy as an optimal solution. The results show that Indonesian diasporas often experience a dilemma between the desire to contribute to the homeland and the limitations imposed by the single citizenship status. A dual citizenship policy is seen as a potential measure to increase diaspora participation in national development. In addition, the research identifies the importance of a national strategy that includes comprehensive diaspora mapping, flexible engagement mechanisms, brain circulation programs, and economic initiatives such as diaspora bonds. However, challenges in implementing these policies include issues of dual loyalty and administrative complexity. The implications of this research include recommendations to revise citizenship laws, develop an integrated diaspora database, and create special programs for diaspora youth. This research makes an important contribution to understanding state-diaspora relations and emphasizes the urgency of an inclusive policy approach in the era of globalization to maximize diaspora potential for national development.
Strategi Peningkatan Kecerdasan Linguistik melalui Permainan Crossword Puzzle di Sd Negeri 2 Kertasari
Authors: Umar Gani Satrio , Dwi Puspita Ryan
Published: November 2024

Kecerdasan linguistik merupakan salah satu aspek penting dalam pendidikan dasar yang mempengaruhi kemampuan siswa dalam berkomunikasi dan memahami teks. Penelitian ini bertujuan untuk mengeksplorasi pengaruh permainan crossword puzzle sebagai metode pembelajaran interaktif terhadap perkembangan kecerdasan linguistik siswa di SD Negeri 2 Kertasari. Kecerdasan linguistik merupakan salah satu kecerdasan yang penting bagi siswa dalam memahami bahasa, baik secara lisan maupun tulisan. Metode crossword puzzle diharapkan dapat menjadi salah satu media pembelajaran yang menarik dan efektif untuk meningkatkan kemampuan linguistik siswa. Penelitian ini menggunakan metode eksperimen dengan desain pretest-posttest yang melibatkan 11 siswa kelas 4 SD sebagai sampel. Data dikumpulkan melalui tes pretest dan posttest, kemudian dianalisis menggunakan uji t untuk melihat signifikansi perbedaan antara nilai rata-rata sebelum dan sesudah intervensi. Hasil analisis menunjukkan bahwa terdapat peningkatan yang signifikan pada nilai rata-rata skor pretest sebesar 52,27 dan rata-rata skor posttest meningkat menjadi 80. Uji t menunjukkan t stat sebesar -8,89776 dengan p-value yang sangat kecil (p < 0,00001), yang menunjukkan bahwa perbedaan antara pretest dan posttest adalah signifikan. Dengan derajat kebebasan 10, nilai t kritis pada tingkat signifikansi 0,05 (dua-tailed) adalah ±2,228. Hal ini menunjukkan bahwa hipotesis nol (tidak ada pengaruh) ditolak, sehingga dapat disimpulkan bahwa penggunaan crossword puzzle memberikan pengaruh positif yang signifikan terhadap perkembangan kecerdasan linguistik siswa
Spine3d: Evaluation of Deformity in Patients with Idiopathic Scoliosis: A Case Series
Authors: Daniele Mazza
Published: November 2024

Idiopathic scoliosis is a complex orthopedic condition marked by a lateral spinal curvature, typically affecting children and adolescents. The Cobb angle is a key metric for evaluating scoliosis severity through X-rays, but its measurement can suffer from variability due to imaging quality, positioning and physician experience, with an acceptable range of variation up to 5 degrees. LiDAR technology offers advantages over traditional methods, as it eliminates ionizing radiation and provides precise three-dimensional representations of the body. This study aims to assess the accuracy and reproducibility of Spine3D, a LiDAR-based tool, in measuring the Cobb angle in idiopathic scoliosis patients.

This study, conducted at Sant’Andrea University Hospital in Rome from September 2022 to September 2024, focused on adolescents (ages 10-18) with idiopathic scoliosis, excluding those with secondary curves or relevant health issues. Informed consent was obtained and body metrics were recorded. The Spine3D system, utilizing infrared technology for non-invasive spine assessment, measured alignment and generated detailed reports on parameters such as the Cobb angle and spinal curvature. Out of 29 participants, 26 were analyzed, showing an average Cobb angle of 29.9 degrees. Results indicated measurements of shoulder asymmetry, pelvic tilt, kyphotic and lordotic angles, with no significant statistical variations observed.

The measurement of the Cobb angle using Spine3D has demonstrated excellent reliability and efficiency. It is therefore suggested to promote the use of this method in clinical practice, alongside radiographic monitoring. Further studies will be needed to evaluate the spinal curvatures measured using Spine3D and traditional radiology.
Involución de isquemia como medida de respuesta a tratamiento en Enfermedad de Kawasaki, seguimiento a largo plazo mediante tomografía por emisión de fotón simple sincronizado con el electrocardiograma
Authors: Mancilla Blanca Nohely Carlos , García Juan Francisco García , Vizarretea Erick Miguel Santome , Hernández Yoalli Jacob Montoya
Published: November 2024

La enfermedad de Kawasaki (EK) es una enfermedad sistémica inflamatoria, de etiología desconocida, con manifestaciones cardiovasculares como anormalidades en arterias coronarias, por ejemplo, la formación de aneurismas en el 5-25%(1,2). Objetivo: Seguimiento a largo plazo de caso con EK por tomografía por emisión de fotón simple sincronizado con el electrocardiograma (GATED-SPECT). Método: Mediante GATED-SPECT se realizó seguimiento a femenino diagnosticada con EK desde 2012, tratada con dos pulsos de inmunoglobulina. Ecocardiograma 2012: dilatación aneurismática de arteria coronaria derecha (4.3mm) y tronco coronario izquierdo (3.8mm). Resultados: Seguimiento de los aneurismas coronarios y sus repercusiones.
ENSINO, PESQUISA E EXTENSÃO: AÇÕES DIRECIONADAS A PESSOAS PRIVADAS DE LIBERDADE
Authors: SIEBRA FONTELES LOPES ALINE
Published: November 2024

Neste estudo são analisados a partir dos pilares da governança, da política de inclusão e da política de educação superior Instituto Federal de Educação Ciência e Tecnologia do Ceará os desafios postos à instituição sobre inclusão de pessoas privadas de liberdade. O objetivo deste estudo é apresentar a análise dos dados das principais ações de Ensino, Pesquisa e Extensão que o Instituto Federal de Educação Ciência e Tecnologia do Ceará tem planejado e implementado no que se refere a inclusão de pessoas privadas de liberdade (PPL), no lastro temporal 2005 a 2023 mediante aquilo que foi expresso em seu Plano de Desenvolvimento Institucional em comparação com o ingresso de PPL no ensino, ações de extensão e de pesquisa realizadas pela instituição. A pesquisa é exploratória, de caráter qualitativo.
10 ANOS DE PSICOMOTRICIDADE RELACIONAL NA ESCOLA PÚBLICA DE FORTALEZA E A PROMOÇÃO DE SAÚDE NA INFÂNCIA
Authors: BARROS DE FREITAS PRISCILA , LOBO MIRANDA LUCIANA , E SILVA LUCENA YANA FABRÍCIA , GONÇALVES LEITE MARIA BEATRIZ
Published: November 2024

O presente artigo tem como objetivo apresentar em linhas gerais o trabalho que é realizado pela Psicomotricidade Relacional em algumas escolas públicas do município de Fortaleza e suas contribuições para a promoção de saúde na infância. O Programa Psicomotricidade Relacional na escola teve início no ano de 2013 com a realização de uma pesquisa piloto para implantação de tal atividade nas escolas, intitulada Alfabetização de crianças na idade certa: contribuições da Psicomotricidade Relacional por meio da promoção da saúde emocional de alunos e professores de uma rede municipal de ensino. Desde então a Psicomotricidade Relacional faz parte da rotina diária de algumas escolas há 10 anos initerruptamente. Para discutir esta proposição, nos baseamos nas contribuições dos criadores e percussores desta prática, são eles, Lapierre, Aucoutorrier, Batista e Vieira. Com relação aos conceitos de infância, teremos como base os estudos e pesquisas da sociologia da infância encabeçadas por Sarmento, Castro, entre outros. A análise deste estudo corrobora com a ideia de que a Psicomotricidade Relacional na escola pôde durante os anos de sua implantação na escola pública favorecer a promoção de saúde na infância, bem como, é fundamental que, na escola, o lugar de fala das crianças deve ser garantido como sujeito político. Desta forma, esta pesquisa pode contribuir com o processo de avaliação de políticas públicas voltadas a educação e a infância, reiterando a importância da pesquisa constante na educação.
PLATAFORMA DE AVALIAÇÃO E MONITORAMENTO DA EDUCAÇÃO BÁSICA DO ESTADO DE MATO GROSSO
Authors: SALDANHA CARNEIRO NILCÉIA
Published: November 2024

Este estudo qualitativo retrata a Avaliação de monitoramento de entrada e saída na Educação Básica do Estado de Mato Grosso aplicada para Ensino Fundamental e Ensino Médio. O objetivo foi identificar, no início do ano de 2024, o desenvolvimento do estudante em relação ao ensino/aprendizagem – leitura/escrita e raciocínio lógico, nas disciplinas de Língua Portuguesa e Matemática. A base foi o Sistema Estruturado de Ensino (SEE). O referencial que teórico- metodológico que embasa a pesquisa é Freitas que traz conceitos e reflexões sobre o modelo pronto trazido pelo estado para a inflexão para reflexão e retomada de ação. A pesquisa consta com os dados obtidos, por meio da plataforma do Sistema de Gestão de Aprendizagem (SGA), que está inserida dentro da plataforma Plurall. A questão que norteia a pesquisa foi: quais as melhorias/benefícios que a parceria entre SEE pertencente à Fundação Getúlio Vargas (FGV) com a SEDUC trouxeram para a rede estadual de educação de Mato Grosso? Pretendeu-se verificar as implicações dos processos de ensino ao que se refere à essa política pública de governo. Identificou-se três abordagens nos métodos de avaliação: i) método tradicional – prova com questões fechadas sem dissertação ou sem momento reflexivo; ii) dados fechados prontos para serem trazidos para o contexto educacional sem momento de reflexão do professor de Língua Portuguesa e Matemática; iii) perguntas que já havia sido trabalhada em sala – “decoreba”. O trabalho identificou os seguintes resultados: a) alunos que assistiram todas as aulas e tem facilidade em decorar foram bem na avaliação; b) resultados já fechados sem possibilidades de questionamento; c) avaliação com proposta bimestral com repetição de conteúdo estudado em sala com a mesma atividade.
REVISÃO BIBLIOGRÁFICA SOBRE O NOVO ENSINO MÉDIO NO ESTADO DE PERNAMBUCO: A PERCEPÇÃO DOS ESTUDANTES BRASILEIROS SOBRE A REFORMA
Authors: SOARES DA SILVA DANIELE , ALVES CAU JOSE NILDO
Published: November 2024

O presente artigo propõe mapear as produções acadêmicas sobre a reforma do Ensino Médio no contexto do estado de Pernambuco, buscando evidenciar, através de estudos, a percepção dos discentes brasileiros e analisar as últimas atualizações realizadas na reforma por meio do projeto de Lei 5.230/2023. Situado no campo de políticas públicas, o estudo proposto servirá como base para construção teórica e analítica do projeto de pesquisa de mestrado que objetiva investigar a percepção dos estudantes de uma Escola Técnica Estadual (ETE) em Pernambuco sobre a implementação do Novo Ensino Médio (NEM) Integrado. Para construção das reflexões, realizou-se uma pesquisa com abordagem qualitativa ancorada no materialismo histórico dialético, visando compreender as relações sociais, históricas e econômicas que influenciam as mudanças no sistema educacional. A análise dos estudos revelou uma convergência crítica sobre a reforma entre pesquisadores e participantes, apontando, em Pernambuco, políticas curriculares verticais e descontextualizadas, promoção do individualismo e da competitividade, estratégias estatais para controlar as manifestações dos trabalhadores, submissão do currículo à lógica capitalista, além de precarização do trabalho e mercantilização da vida por meio do incentivo ao empreendedorismo. Identificaram-se lacunas na comunicação entre os órgãos responsáveis e o público-alvo da política e a ausência de participação pública nas consultas para a construção da lei. Evidenciou-se a falta de análises pós-implementação do NEM em Pernambuco, especialmente nas ETEs, e a lacuna de investigação sobre a percepção dos estudantes no estado, ressaltando a urgência de envolvê-los ativamente nas discussões e implementações das reformas curriculares.
A PANDEMIA DE COVID-19 E A EDUCAÇÃO SUPERIOR A DISTÂNCIA NO BRASIL: OLHANDO ATRAVÉS DO CENSO DA EDUCAÇÃO SUPERIOR
Authors: SANTANA DE FREITAS VALÉRIA , DE MACÊDO MOTA JÚNIOR ANTÔNIO
Published: November 2024

A educação superior em seu formato a distância, como tendência mundial, teve um crescimento significativo no Brasil, nos últimos anos. A expansão na oferta desses cursos em relação aos totalmente presenciais, em certa medida, tem sido motivo de questionamentos quanto à qualidade do ensino. Este estudo, motivado pelo interesse em compreender o cenário atual e os rumos da Educação à distância em nosso país, tem como objetivo analisar os principais pontos no desenvolvimento e possíveis entraves dessa modalidade de ensino da educação superior. Para tanto, este trabalho apresenta os resultados de uma pesquisa de natureza exploratória e descritiva, que se utiliza como procedimentos o levantamento bibliográfico e a análise documental, baseada, principalmente, em informações da educação superior à distância no Brasil, nos últimos 10 anos, a partir da observação de dados extraídos do Censo da Educação Superior 2022 e do Relatório Sinopse Estatística do Enade 2021. O presente estudo analisa, nesse contexto, um fator que não se pode suprimir: os impactos da Pandemia da Covid-19 na qualidade dos processos de ensino-aprendizagem. Como resultados, as informações e análises demonstram que a educação superior a distância passa por mais um momento de mudanças, em busca de um novo estágio de adaptação, sem que se perca a qualidade.