bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatic transcript signatures predict atherosclerotic lesion burden prior to a 2-year high cholesterol, high fat diet challenge
Authors: Puppala Sobha , Spradling-Reeves Kimberly D. , Chan Jeannie , Birnbaum Shifra , Newman Deborah E. , Comuzzie Anthony G. , Mahaney Michael C. , VandeBerg John L. , Olivier Michael , Cox Laura A.
Published: August 2022

The purpose of this study was to identify molecular mechanisms by which the liver influences total lesion burden in a nonhuman primate model (NHP) of cardiovascular disease with acute and chronic feeding of a high cholesterol, high fat (HCHF) diet. Baboons (47 females, 64 males) were fed a HCHF diet for 2 years (y); liver biopsies were collected at baseline, 7 weeks (w) and 2y, and lesions were quantified in aortic arch, descending aorta, and common iliac at 2y. Unbiased weighted gene co-expression network analysis (WGCNA) revealed several modules of hepatic genes correlated with lesions at different time points of dietary challenge. Pathway and network analyses were performed to study the roles of hepatic module genes. More significant pathways were observed in males than females. In males, we found modules enriched for genes in oxidative phosphorylation at baseline, opioid signaling at 7w, and EIF2 signaling and HNF1A and HNF4A networks at baseline and 2y. One module enriched for fatty acid β oxidation pathway genes was found in males and females at 2y. To our knowledge, this is the first study of a large NHP cohort to identify hepatic genes that correlate with lesion burden. Correlations of baseline and 7w module genes with lesions at 2y were observed in males but not in females. Pathway analyses of baseline and 7w module genes indicate EIF2 signaling, oxidative phosphorylation, and μ-opioid signaling are possible mechanisms that predict lesion formation induced by HCHF diet consumption in males. Our findings of coordinated hepatic transcriptional response in male baboons but not female baboons indicate underlying molecular mechanisms differ between female and male primate atherosclerosis.
Instructing children to construct ideas into products alters children’s creative idea selection in a randomized field experiment
Authors: van Broekhoven Kim , Belfi Barbara , Borghans Lex
Published: August 2022

Many popular pedagogical approaches instruct children to construct their ideas into tangible and physical products. With the prospect of implementation, do children decide to go for the most creative ideas or do they shift towards ideas that are perhaps less creative but easier to construct? We conducted a field experiment to test whether expected construction affects children’s creative idea selection. In this experiment, 403 children were asked to select the most original ideas to make a toy elephant more fun to play with. We randomly assigned them to a treatment condition—in which they were informed they had to construct one of the original ideas that they selected—and a control group—in which children were informed that, after idea selection, they had to perform another task. Children who were instructed to construct the selected idea into a tangible product turned a blind eye to original ideas and preferred the more feasible ideas. Thus, pedagogical approaches that aim to stimulate creativity by instructing children to construct original ideas into tangible and physical products may unintentionally change children’s choices for creative ideas. This finding highlights the importance for educators of guiding children’s decision-making process in creative problem solving, and to be aware of children’s bias against original ideas when designing creative assignments for them.
Prognostic nutritional index as a prognostic factor for renal cell carcinoma: A systematic review and meta-analysis
Authors: Shim Sung Ryul , Kim Sun Il , Kim Se Joong , Cho Dae Sung
Published: August 2022

Background

Prognostic nutritional index (PNI) is a simple parameter which reflects patient’s nutritional and inflammatory status and reported as a prognostic factor for renal cell carcinoma (RCC). Studies were included from database inception until February 2, 2022. The aim of this study is to evaluate prognostic value of PNI by meta-analysis of the diagnostic test accuracy in RCC.

Methods and findings

Studies were retrieved from PubMed, Cochrane, and EMBASE databases and assessed sensitivity, specificity, summary receiver operating characteristic curve (SROC) and area under curve (AUC). Totally, we identified 11 studies with a total of 7,296 patients were included to evaluate the prognostic value of PNI in RCC finally. They indicated a pooled sensitivity of 0.733 (95% CI, 0.651–0.802), specificity of 0.615 (95% CI, 0.528–0.695), diagnostic odds ratio (DOR) of 4.382 (95% CI, 3.148–6.101) and AUC of 0.72 (95% CI, 0.68–0.76). Heterogeneity was significant and univariate meta-regression revealed that metastasis and cut-off value of PNI might be the potential source of heterogeneity. Multivariate meta-regression analysis also demonstrated that metastasis might be the source of heterogeneity.

Conclusions

PNI demonstrated a good diagnostic accuracy as a prognostic factor for RCC and especially in case of metastatic RCC.
Diné Navajo Resilience to the COVID-19 pandemic
Authors: Denetclaw Wilfred F. , Otto Zara K. , Christie Samantha , Allen Estrella , Cruz Maria , Potter Kassandra A. , Mehta Kala M.
Published: August 2022

Objective

To date, there are no studies of COVID-19 cases and deaths in the Navajo Nation, US. The primary objective of this manuscript is to understand whether counties with a higher proportion of Navajo (Diné) population also had higher cases and deaths of COVID-19 and whether these dropped with vaccination.

Method

We undertook a cross-sectional analysis of county level data from March 16, 2020—May 11, 2021. Data were obtained from public repositories and the US Census for the Navajo Nation, including northeastern Arizona, southeastern Utah, and northwestern New Mexico. The primary outcome measure is the number of individuals with confirmed cases or deaths of COVID-19. A secondary outcome was COVID-19 vaccinations.

Results

The 11 counties in Navajo Nation have a wide variation in the percent Navajo population, the resources available (ICU beds and occupancy), and COVID-19 outcomes. Overall, there was a substantial increase in the number of cases from March 16 –July 16, 2020 (the height of the pandemic) with a doubling time of 10.12 days on Navajo Nation. The percent Navajo population was a strong predictor of COVID-19 cases and deaths per million population. COVID-19 vaccinations were inversely associated with COVID-19 cases and deaths in these counties.

Conclusions

The COVID-19 pandemic on the Navajo Nation is a story of resilience. Navajo Nation was one of the hardest hit areas of the United States, with peak cases and deaths due to COVID-19. With an aggressive vaccination effort, these cases and deaths were strikingly curtailed, showing the resilience of the Navajo (Diné) people.
Effects of infant age and sex, and maternal parity on the interaction of lactation with infant feeding development in chimpanzees
Authors: Bădescu Iulia , Watts David P. , Curteanu Cassandra , Desruelle Kelly J. , Sellen Daniel W.
Published: August 2022

The interaction between infant feeding and maternal lactational physiology influences female inter-birth intervals and mediates maternal reproductive trade-offs. We investigated variation in feeding development in 72 immature wild chimpanzees (Pan troglodytes schweinfurthii) at Ngogo, Kibale National Park, Uganda, and made inferences about maternal lactation over the course of infancy. We compared the percentage (%) of time that mothers nursed infants as a function of infant age and assessed how hourly rates and bout durations of nursing and foraging varied in association with differences in offspring age, sex, and maternal parity. Nursing % times, rates and durations were highest for infants ≤ 6 months old but did not change significantly from 6 months to 5 years old. Nursing continued at a decreasing rate for some 5- to 7-year-olds. Infants ≤ 6 months old foraged little. Foraging rates did not change after 1 year old, but foraging durations and the % time devoted to foraging increased with age. Independent foraging probably became a dietary requirement for infants at 1 year old, when their energy needs may have surpassed the available milk energy. Infants spent as much time foraging by the time they were 4 to 5 years old as adults did. No sex effect on infant nursing or foraging was apparent, but infants of primiparous females had higher foraging rates and spent more time foraging than the infants of multiparous females did. Although no data on milk composition were collected, these findings are consistent with a working hypothesis that like other hominoids, chimpanzee mothers maintained a fixed level of lactation effort over several years as infants increasingly supplemented their growing energy, micronutrient and hydration needs via independent foraging. Plateauing lactation may be a more widespread adaptation that allows hominoid infants time to attain the physiology and skills necessary for independent feeding, while also providing them with a steady dietary base on which they could rely consistently through infancy, and enabling mothers to maintain a fixed, predictable level of lactation effort.
Perception regarding live kidney donation in the general population of South Korea
Authors: Kang Eunjeong , Lee Jangwook , Park Sehoon , Kim Yaerim , Kim Hyo Jeong , Kim Yong Chul , Kim Dong Ki , Joo Kwon Wook , Kim Yon Su , Choi Insun , Lee Hajeong
Published: August 2022

This study aimed to know how the general population recognizes live kidney donation in Korea. Participants were randomly selected from the general population after proportional allocation by region, sex, and age. Selected participants received a questionnaire that included demographic information, socioeconomic and marital statuses, prior recognition of live donor kidney transplantation, expected changes after donation, and the need for support after donor nephrectomy. Among the 1,000 participants from the web-based survey, 83.8% answered they fully understood living donor kidney transplantation, 81.1% knew about them, and 51.1% were willing to donate. Various complications after nephrectomy and deterioration in health after donation were the most significant reasons for those reluctant to donate. Most agreed that the government should provide social and economic support to living kidney donors, especially after exposure to the description of donor nephrectomy. Financial support, including surgery and regular medical check-up costs, was the most preferred government support. The Korean general population seemed aware of the value and safety of kidney donation, although only half of them were willing to donate due to concerns about possible complications. Most participants agreed on social and economic support for living kidney donors, especially surgery-related costs.
Impact of the participation of rural households in the appraisal on poor households’ identification
Authors: Liu Yusong , Zheng Linyi
Published: August 2022

Developing countries have common goals of poverty eradication and improving people’s livelihoods. As the largest developing country, China has made remarkable achievements in poverty alleviation during the 30 years of reform. Although a targeted poverty alleviation mechanism was established by the Chinese government in 2013, the identification of poor households has been an arduous journey. Based on a total of 688 samples of grassroots officials and 2,621 rural households from 69 village-level divisions in 9 provinces in China, this study conducted cross-validation on the impact of the participation of rural households in the identifying poor households that required government assistance. This was from the perspectives of grassroots officials and rural households. It was investigated whether this participation led to an anomaly between the identification of poor households and the actual situation. Empirical results show that the participation of rural households in appraisals significantly increases the probability of identifying a non-poor household as a poor household (first error) and decreases the probability of failing to identify a poor household as a poor household (second error). As the impact of the first error is greater than that of the second error, the participation of rural households in appraisals has the overall effect of increasing the incorrect registrations of poor households. These results are still valid after addressing the self-selection problem. For other developing countries to successfully apply effort into poverty alleviation, in addition to focusing on increasing farmers’ participation in public affairs, they should prevent any bias that may be caused by farmers’ participation in public affairs; strengthen publicity and guidance; focus on the nurture of officials; perfect top-level design; and set clearer targets for poverty alleviation policies.
Safety evaluation of visual load at entrance and exit of extra-long expressway tunnel based on optimized support vector regression
Authors: Shang Ting , Lu Hao , Lu Jiaxin , Fan Jing
Published: August 2022

The traffic environment of an extra-long expressway tunnel is more complex than that of a long tunnel, which increases the driving risk. The visual load of drivers can be used to evaluate driving safety and comfort. To reveal drivers’ visual load characteristics at the entrance and exit of extra-long tunnels on mountainous expressways, this study conducted vehicle tests with 12 drivers at Gonghe extra-long tunnel on the Yu-Xiang expressway in the Wulong District. An eye tracker, non-contact multifunctional velocimetry, illuminometer, and other test equipment were used to record drivers’ pupil areas, velocity, and illuminance when entering and leaving the tunnel. The change characteristics of drivers’ pupil areas were studied. The maximum transient velocity value (MTPA) of the pupil area was selected as an index to evaluate the visual load degree. Based on velocity and illuminance coupling, a visual load model was constructed using the optimized support vector machine (GA-SVM). The influence of velocity and illuminance on the MTPA in the tunnel’s approach, entrance, exit, and departure section was analyzed. The results show that drivers’ psychological tension order at the entrance and exit is entrance section ≈ exit section > departure section > approach section. In the approach section, the visual load is mainly affected by environmental illumination. In the entrance and exit sections, the visual load is positively correlated with velocity and negatively correlated with illuminance, and velocity has a greater impact on visual load. In the tunnel departure section, the two variables synergistically influence the driving visual load. The research results provide theoretical support for the safety design and management of extra-long tunnel entrances and exits.
Internalizing and externalizing mental health problems affect in-school adolescent’s health-related quality of life in eastern Ethiopia: A cross-sectional study
Authors: Hunduma Gari , Dessie Yadeta , Geda Biftu , Yadeta Tesfaye Assebe , Deyessa Negussie
Published: August 2022

Aims

This study aimed to examine the association between mental health problems and health-related quality of life (HrQoL) among in-school adolescents 13–19 years in the Harari region, eastern Ethiopia.

Materials and methods

A cross-sectional study was conducted on 3227 in-school adolescents aged 13 to 19 using multistage sampling. The KIDSCREEN-10 questionnaire assessed health-related quality of life (HrQoL), while a self-administered version of the strength and difficulty questionnaire (SDQ) examined mental health issues. Data were double entered, validated, and cleaned using EpiData version 3.1 and analyzed using STATA 14.1. An ordinal logistic regression model investigated the link between the outcome variable and the predictors. The results were reported using an odds ratio with a 95% confidence interval (CI), and a p-value of less than 0.05 was considered statistically significant.

Results

A quarter of the adolescents (23%) reported poor health-related quality of life; adolescents with internalizing and externalizing mental health problems had the lowest health-related quality of life. After controlling for potential confounders, adolescents with abnormal (AOR = 0.48, 95% CI: 0.39, 0.59) and borderline (AOR = 0.59, 95% CI: 0.45, 0.78) levels of internalizing problems had a 52% and 41% lower probability of having high HrQoL than those with normal levels. Furthermore, individuals with abnormal (AOR = 0.59, 95% CI: 0.45, 0.77) and borderline (AOR = 0.64, 95% CI: 0.45, 0.92) levels of externalizing difficulties had a 41% and 36% lower chance of having a high health-related quality of life.

Conclusions

Nearly a quarter of in-school adolescents had poor health-related quality of life. High scores for internalizing and externalizing mental health problems significantly impacted the adolescents’ health-related quality of life. This emphasizes the need to address mental health issues in the school setting to improve adolescents’ overall quality of life.
C3aR plays both sides in regulating resistance to bacterial infections
Authors: Corcoran Jesse A. , Napier Brooke A.
Published: August 2022

Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection. Specifically, previous research has identified mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune cell inflammatory state, antimicrobial killing capacity, and metabolism. Historically, the production of C3a has been relegated to the serum; however, recent studies have provided evidence that various cell types can produce intracellular C3a that stimulates intracellular C3aR. In light of these new results, it is imperative that we revisit previous studies regarding the role of C3aR in controlling bacterial infections and analyze these results in the context of both extracellular and intracellular C3a production and C3aR activation. Thus, this review will cover specific roles of C3aR in driving cell type–specific and tissue specific responses during bacterial infections and emphasize the contribution of the C3a–C3aR axis in regulating host resistance to bacterial infection.
Assessing Inductive Reasoning, Scientific Reasoning and Science Motivation
Authors: Vo De Van
Published: August 2022

Jelen kutatás célja, hogy feltárja a gondolkodási képességek és a természettudományos motiváció változó mintázatát, valamint azok kapcsolatát a tanulók háttérváltozóival különböző évfolyamokon. Három keresztmetszeti vizsgálatot végeztünk 2241 diákkal 16 vietnami állami iskolában. Az első tanulmány az 5., 7., 9. és 11. osztályos tanulók induktív gondolkodásának és természettudományos motivációjának alakulását vizsgálta. Az eredmények azt mutatták, hogy az induktív gondolkodási teszteken az idősebb korosztályok tagjai átlagosan magasabb pontszámot érnek el, mint a fiatalabb társaik, de a diákok természettudományos motivációja fokozatosan csökken az évfolyam emelkedésével. A több modellből álló Bayesiánus következtetés kimutatta, hogy az induktív gondolkodás, a természettudományos teljesítmény és a szülői bevonódottság a természettudományos motiváció fő előrejelzői. Ezenkívül az útelemzés kimutatta, hogy az induktív érvelés közvetett hatással van a természettudományos motivációra a természettudományos teljesítmény egyik változóján keresztül. A második tanulmány, amely a 6., 8., 10. és 11. osztályosoknál értékelte a gondolkodási képességeket és a természettudományos motivációt, kimutatta, hogy a diákok az induktív és a természettudományos gondolkodási teszteken elért eredményei évfolyamonként javultak. Az útelemzés eljárása alapján arra lehet következtetni, hogy az induktív gondolkodás, a természettudományos gondolkodás, az apa végzettsége és a szülői bevonódottság a STEM eredményeket megjósoló fő tényezők. A harmadik tanulmány keretében a fizika tantárgy területén egy természettudományos gondolkodási tesztet dolgoztunk ki annak mérésére, hogy a tanulók milyen mértékben alkalmazzák a változók ellenőrzésének stratégiáját a 8-12. osztályosok körében. A teszt megbízhatóságát és érvényességét a Rasch modell igazolta. A fizika területén is megfigyelhető volt a tanulók fejlődése a változók ellenőrzésének stratégiájának alkalmazásában, azonban a fizika tanulásának motivációja kismértékben csökken az évfolyamok előrehaladtával. Nem volt kimutatható szignifikáns különbség a fiúk és a lányok között a gondolkodási képességek és a természettudományos motiváció területén, azonban a fizika tanulásának motivációjában a fiúk javára szignifikáns különbség figyelhető meg. A gondolkodási képességek és a természettudományos motiváció fejlesztésének lehetséges eljárásai és azok hatásai szintén megvitatásra kerülnek.
Reflective Teaching Model for Reading Comprehension
Authors: Oo Tun Zaw
Published: August 2022

A kutatás célja az olvasás-szövegértés reflektív tanítási modelljének kidolgozása és hatékonyságvizsgálata volt mianmari tanulók körében osztálytermi környezetben megvalósítva. A célkitűzés eléréséhez először a reflektív tanítás, az olvasás-szövegértés és a tanítási folyamat tervezése területéről származó szakirodalom áttekintése valósult meg, és ez alapján történt az olvasás-szövegértés reflektív tanítására vonatkozóan új modell megalkotása. A modell alapját a tervezés, a tanítási-tanulási tevékenységek, a reflektálás és az értékelés jelentette. Ezután a reflektív tanítással kapcsolatos empirikus kutatások összehasonlítására került sor, és új módszertani ötletek gyűjtése történt egy, a mianmari kontextushoz leginkább illeszkedő kutatás elvégzéséhez. A kutatáshoz három stratégiát választottunk ki, ezek a reciprok tanítás, az interaktív tanítás és a kérdezési stratégiák. Az olvasás-szövegértéshez kapcsolódó reflektív tanítási modell kidolgozása után az empirikus kutatások tervezése és megvalósítása következett az angol mint idegen nyelv tanításához kapcsolódóan a tanórákba építve. A kutatáshoz használt mérőeszközök angol nyelvű elő- és utóteszteket, továbbá tanulói kérdőívet és megfigyelési szempontsort foglaltak magukba, valamint a tanárok számára részletes óravázlatok készültek a fejlesztéshez kapcsolódóan. A pilot vizsgálat és a mérőeszközök validálása után következett a mérőeszközök felülvizsgálata. A nagymintás mérésben az olvasás-szövegértés reflektív tanítási modelljének hatékonyságmérése történt meg fejlesztő program keretében. A fejlesztésben kísérleti és kontrollcsoportos tanulók vettek részt. A nagymintás mérésben a három tanítási stratégia használata alatt (a reciprok tanítás, az interaktív tanítás és a kérdezési stratégiák) a tanulók interaktív szerepbe kerültek és a tudásuk aktív konstruálására nyílt lehetőségük. A kutatás arra mutatott rá, hogy az olvasás-szövegértés reflektív tanítási modelljén alapuló tanítási stratégiák tudatos használata szignifikánsan fejleszti a tanulók olvasás-szövegértését, a tanárokat is reflektív tevékenységre ösztönzi, így hatékonyan alkalmazhatóak a tanítási-tanulási folyamatban.
Crítica da Patologização das Identidades/Alteridades no Mundo da Vida / Critique of the Pathologization of Identities/Alterities in the World of Life
Authors: Souza Filho José Alves , Lima Aluísio Ferreira de
Published: August 2022

Este ensaio problematiza a patologização do sofrimento psíquico contemporâneo enquanto produto da minimização ético-política das identidades/alteridades no mundo da vida contemporâneo. Para além da semântica do sofrimento psíquico, discutimos as psicopatologias como políticas de identidades, materializadas nas estratégias de garantia e/ou privação de direitos, nas formas de reconhecimento que pervertem a construção de projetos de vida emancipatórios. Partimos do referencial teórico-metodológico da Psicologia Social Crítica e da Teoria Crítica da Sociedade: por um lado, problematiza-se como as identidades-metamorfoses dos sujeitos podem evidenciar a patologização de projetos de vida em função das intervenções sistêmicas do capitalismo contemporâneo; por outro apresentamos uma crítica da racionalidade instrumental no adoecimento contemporâneo. Assim, discutimos a incidência da produção das subAlteridades enquanto manutenção do adoecimento dentro das tecnologias de cuidado/cura.Palavras-chave: Identidade; Patologização; Mundo da Vida, Psicologia Social; Teoria Crítica da Sociedade.  Abstract: This essay problematizes the pathologization of contemporary psychic suffering as a product of the ethical-political minimization of identities/alterities in the contemporary world of life. In addition to the semantics of psychic suffering, we discuss psychopathologies as identity politics, materialized in the strategies of guarantee and/or deprivation of rights, in the forms of recognition that pervert the construction of emancipatory life projects. We start from the theoretical-methodological framework of Critical Social Psychology and Critical Theory of Society: on the one hand, we discuss how the subjects' identities-metamorphoses can evidence the pathologization of life projects as a result of the systemic interventions of contemporary capitalism; on the other hand, we present a critique of instrumental rationality in contemporary illness. Thus, we discuss the incidence of the production of sub-Alterities while maintaining the illness within the technologies of care/cure.Keywords: Identity; Pathologization; Life World, Social Psychology; Critical Theory of Society
O potencial uso da microalga Porphyridium cruentum na prevenção do envelhecimento cutâneo / The potential use of the microalgae Porphyridium cruentum in the prevention of skin aging
Authors: Rossi Anna Julia , Machado Karina Elisa
Published: August 2022

Nos últimos anos observou-se um aumento da população que procura envelhecer, sem demonstrar os sinais dos anos vividos, que podem ser evidenciados através de rugas, linhas de expressão, flacidez e discromias. Destaca-se que o envelhecimento é um processo natural, caracterizado por alterações morfológicas, bioquímicas e fisiológicas, que ocorrem progressivamente, com o passar dos anos. Entre os diversos ativos cosméticos, que podem ser utilizados para prevenir o envelhecimento cutâneo, para o presente trabalho selecionou-se as microalgas. Nesta perspectiva, através de uma revisão bibliográfica descritiva com abordagem qualitativa, o presente artigo tem como objetivo analisar o potencial uso da microalga marinha Porphyridium cruentum na prevenção do envelhecimento cutâneo. Os resultados obtidos demonstraram que, o uso da microalga Porphyridium cruentum na prevenção do envelhecimento cutâneo, pode ser benéfica, considerando que esta possui ativos antioxidantes, e que, os cosméticos antioxidantes são considerados importantes na prevenção do envelhecimento cutâneo.Abstract: In recent years, there has been an increase in the population that ages, without showing the signs of the years lived, which can be evidenced through wrinkles, expression lines, sagging and dyschromia. It is noteworthy that aging is natural, being modified by biological changes, which can be a morphological-chemical process, which changes from chemical-years, over the years. Among the various cosmetic actives, which can be used to prevent skin aging, microalgae was selected for the work. In this, through a descriptive literature review with a qualitative approach, this article aims to analyze the potential use of the marine microalgae porridium cruentum in the protection of skin aging. The antioxidant results that contain, the use of skin food prevention, can be, that is safe, antioxidants are considered in the prevention of skin aging.Keywords: Skin aging. Free radicals. Antioxidants. Microalgae. Porphyridium cruentum.
Origem da Relação entre Malária e Anemia Falciforme / Origin of the Relationship Between Malaria and Sickle Cell Anemia
Authors: Santos Thalita Grazielly , Santos Thatiane Danielly , Santos Junior Nilton Nascimento dos , Santos Mikael Santana dos , Araújo Thatiany Santos , Almeida Jennifer Soares de , Telis João Junior Scapin , Santos Julia De Lima
Published: August 2022

Resumo: A malária é uma doença tropical e parasitária que mais causa impasses sociais e econômicos em todo o mundo, sendo considerada um problema de saúde pública. É causada pelo protozoário do gênero Plasmodium, sendo três espécies os de maiores ocorrências e transmitida pelo mosquito Anopheles.  A anemia falciforme é uma doença sanguínea causada por uma mutação de ponto que permite a formação de uma proteína truncada, a hemoglobina S. Os indivíduos afetados são homozigotos e como consequência fenotípica tem-se o aparecimento de hemácias no formato de foice. O objetivo da revisão narrativa é realizar uma pesquisa bibliográfica que demonstre a relação entre malária e anemia falciforme. Este foi realizado nas bases de dados Scientific Eletronic Library Online (Scielo) e PubMed, cujos descritores consistem em “anemia falciforme”, “relação”, “malária”, “efeito materno”, “hipótese de Haldane”, “sickle cell disease”. A relação entre anemia falciforme e malária é notada, predominantemente, em regiões endêmicas para malária, dado os estudos obtidos por Haldane e a hipótese do efeito materno. Portanto, conclui-se que pessoas portadoras do gene da anemia falciforme possuem relutância em contrair malária.Palavras-chave: anemia falciforme, relação, malária, efeito materno, hipótese de Haldane, sickle cell disease.Abstract: Malaria is a tropical and parasitic disease that causes most social and economic impasses around the world, being considered a public health problem. It is caused by the protozoan of the genus Plasmodium, with three species being the most frequent and transmitted by the Anopheles mosquito. Sickle cell anemia is a blood disease caused by a point mutation that allows the formation of a truncated protein, hemoglobin S. Affected individuals are homozygous and as a phenotypic consequence there is the appearance of sickle-shaped red blood cells. The objective of the narrative review is to carry out a bibliographic research that demonstrates the relationship between malaria and sickle cell anemia. This was carried out in the Scientific Electronic Library Online (Scielo) and PubMed databases, whose descriptors consist of “sickle cell anemia”, “relationship”, “malaria”, “maternal effect”, “Haldane hypothesis”, “sickle cell disease” . The relationship between sickle cell anemia and malaria is noted predominantly in malaria-endemic regions, given the studies obtained by Haldane and the hypothesis of maternal effect. Therefore, it is concluded that people carrying the sickle cell anemia gene are reluctant to contract malaria.Keywords: sickle cell anemia, relationship, malaria, maternal effect, Haldane hypothesis, sickle cell disease.
A Humanização na Assistência de Enfermagem Durante o Pré-Natal no Âmbito da Estratégia Saúde da Família / Humanization in Nursing Care During Prenatal Care in the Scope of the Family Health Strategy
Authors: Novais Cícero Anderson Lourenço Moreira , Novais Érica Lourenço Moreira , Cecílio Caio Vittor Callou , Ramalho Cicero Lucas Gomes , Rocha Rhavena Maria Gomes Sousa
Published: August 2022

Resumo: Este estudo analisa a importância do pré-natal humanizado realizado pela equipe de enfermagem no âmbito da atenção básica, tendo em vista que o enfermeiro tem respaldo legal para realizar todo o pré-natal da gestação de baixo risco. O objetivo desse artigo foi analisar a partir dos estudos disponíveis na literatura a importância do atendimento humanizado nas consultas de pré-natal ofertadas pela Estratégia de Saúde da Família (ESF). Como recurso metodológico utilizou-se a revisão integrativa da literatura, sendo a coleta de dados realizada nas seguintes bases de dados: SciELO, LILACS e BDENF. Foram selecionados oito artigos para esta revisão, que obedeceram aos critérios de inclusão e exclusão do método, dando embasamento necessário para a discussão.  O contexto sociocultural pode influir significativamente na adesão e continuidade da gestante nas consultas de pré-natal. Desse modo, desvelou-se a importância de o profissional de enfermagem integrar os conhecimentos técnico-científicos aos conhecimentos oriundos da própria gestante. É imprescindível o acolhimento humanizado na atenção pré-natal para que se ocorra o fortalecimento de vínculos entre gestante e a equipe multidisciplinar, promovendo assim, maior adesão da parturiente aos cuidados de saúde. Descritores: Cuidado pré-natal; Humanização da assistência; Atenção Primária à Saúde.  Abstract: This study analyzes the importance of humanized prenatal care performed by the nursing team in the context of primary care, given that nurses have legal support to perform all prenatal care for low-risk pregnancy. The objective of this article was to analyze, from the studies available in the literature, the importance of humanized care in prenatal consultations offered by the Family Health Strategy (ESF). As a methodological resource, an integrative literature review was used, and data collection was carried out in the following databases: SciELO, LILACS and BDENF. Eight articles were selected for this review, which met the inclusion and exclusion criteria of the method, providing the necessary basis for the discussion. The sociocultural context can significantly influence the adherence and continuity of pregnant women in prenatal consultations. In this way, the importance of the nursing professional integrating technical-scientific knowledge with the knowledge derived from the pregnant woman herself was revealed. Humanized reception in prenatal care is essential for the strengthening of bonds between pregnant women and the multidisciplinary team, thus promoting greater adherence of the parturient to health care.Keywords: Prenatal care; Humanization of assistance; Primary Health Care.
Le choix de Pierre Faure à la direction de l’Institut Supérieur de Pédagogie de l’Institut catholique de Paris: affirmer les positions doctrinales de la pédagogie chrétienne face à l’impression de chaos suscitée par les méthodes actives
Authors: Gutierrez Laurent
Published: August 2022

La création de l’institut supérieur de pédagogie (ISP) de l’institut catholique de Paris (ICP) en 1941 est une étape importante dans l’histoire de la formation professionnelle des maîtres de l’enseignement catholique français. Si certains y voient la possibilité de participer au perfectionnement pédagogique des professeurs en mettant à l’étude les méthodes actives, d’autres préfèrent profiter de cette occasion pour mener une réflexion sur les fondements théologiques du mouvement de l’éducation nouvelle dont elles sont issues. En nommant Pierre Faure à la direction pédagogique de cet Institut, l’enseignement supérieur catholique affiche sa volonté d’être au plus près des pratiques pédagogiques fidèles à la doctrine chrétienne en contrepoint des découvertes pédagogiques de son époque.
Pedagogia personalizada e comunitária no México: o primeiro curso de verão em Guadalajara (1975)
Authors: Dallabrida Norberto , Leal Norma Cecilia Bross
Published: August 2022

Este artigo se propõe a compreender o primeiro curso de verão animado pelo padre jesuíta francês Pierre Faure, ocorrido em meados de 1975, na cidade de Gualajara, México. Inicialmente, contextualiza-se a circulação da pedagogia personalizada e comunitária proposta por Pierre Faure na América Latina, particularmente no México. Enfocam-se no texto os principais aspectos pedagógicos explorados por Faure em suas palestras, que constituíram o cerne desse curso. À luz da perspectiva historiográfica de Marta Carvalho, considera-se o curso de verão uma estratégia de circulação da pedagogia personalizada e comunitária. O curso de verão de 1975 foi marcante devido à presença pioneira do padre Faure em Guadalajara, que atraiu educadores do México e de outros países.
Estatutos da Escola Doméstica anexa ao Ginásio Auxilium de Anápolis/GO (1940)
Authors: Mendonça Roselene Candida Barroso , Abreu Sandra Elaine Aires de
Published: August 2022

O Colégio Auxilium de Anápolis/GO (atualmente extinto) foi criado em 1937, quando as Irmãs Salesianas assumiram a Escola Normal de Annapolis – unidade de ensino privada mista, criada em 1931 – que passou a ser denominada de Escola Normal Nossa Senhora Auxiliadora, permanecendo uma instituição privada, mas de ensino feminino. Ao iniciar suas atividades, a Escola Nossa Senhora Auxiliadora oferecia, além do ensino normal, outras duas modalidades de ensino: o Oratório Festivo Dominical e a Escola Noturna de Alfabetização e Educação Profissional, sendo estes últimos ofertados gratuitamente (ANDRADE, 2018). Em 1943, a Escola Nossa Senhora Auxiliadora tornou-se um estabelecimento de ensino secundário ao implementar o ensino ginasial. Diante isso, adequou-se ao Decreto-Lei n. 4.244, de 9 de abril de 1942, passando a ser denominada Ginásio Auxilium de Anápolis. O Ginásio tornou-se, assim, um sucessor desta escola e incorporou seu patrimônio de “[...] Cr. $ 500,00, valor dos seus bens imóveis e instalações” (GINÁSIO AUXILIUM, 1943), tornando-se responsável por todos seus bens e encargos, assumindo a administração de todos os seus recursos, inclusive aqueles advindos do poder público (GOIAZ, 1943). O início de suas atividades ocorreu no dia 15 de março de 1943 (COLÉGIO AUXILIUM, 1988). Ao se tornar um Ginásio, essa unidade escolar ofertava, além do curso ginasial, os cursos: primário, complementar, preparatório ao ginásio e normal, com regime de internato, semi-internato e externato. Nessa época, a instituição passara a disponibilizar gratuitamente a Escola Doméstica, além de manter as obras beneficentes já mencionadas.
Regimes de verdade sobre/na constituição do sujeito-professor em meio à pandemia da Covid-19
Authors: Guimarães Mendes Laurianne , Durval Dorne Vinícius
Published: August 2022

A pandemia da COVID-19 impactou as relações sociais e, de certo modo, os espaços e instituições. Dessa forma, o ambiente escolar também foi atingindo por diversas mudanças que reestruturam o processo ensino-aprendizagem e os sujeitos pertencentes a ele. Percebe-se que desde as mudanças mais simples, como o uso da máscara em sala de aula, até mudanças mais profundas, como o ensino remoto ou híbrido, o sujeito-professor é, de certa forma, o que mais experiencia transformações nas suas incumbências dentro do processo ensino-aprendizagem. Frente a isso, neste trabalho, buscamos analisar os regimes de verdade que constituem o sujeito-professor pré-pandêmico e pandêmico tendo como mirante teórico a Análise do Discurso de linha francesa, sobretudo a partir dos trabalhos de Michel Foucault. Tomamos como corpus dois documentos oficiais: a LDB – Leis de Diretrizes e Bases da Educação Nacional e o Guia de Implementação de Protocolos de Retorno das Atividades Presenciais nas Escolas de Educação Básica, formulado pelo Ministério da Educação. A partir deles, procuramos analisar os regimes de verdade que sustentam documentos oficiais que, de certa maneira, fornecem subsídios para a constituição do sujeito-professor ao se ampararem em formações discursivas que delimitam quais ações (não) são/estão condicionadas ao fazer docente. Entre outras reflexões, observou-se que a constituição de um sujeito-professor pré-pandêmico pautada na burocracia e um sujeito-professor pandêmico centrado na figura de cuidador.
Autoimmune spinal cord lesions associated with novel coronavirus infection
Authors: Kozlova A. O. , Eliseeva D. D. , Simaniv T. O. , Bryukhov V. V. , Baidina E. V. , Zakharova M. N.
Published: August 2022

Spinal cord affection, according to various sources, is a common complication of a new coronavirus infection. The article describes various variants of spinal cord pathology in COVID-19, their potential mechanisms of development, approaches to treatment and outcomes of the disease. Three patients who were observed at the Research Center of Neurology and represent the most interesting cases of classic transverse myelitis, myelitis with predominant involvement of the lateral and posterior cords, and longitudinal widespread myelitis associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) are considered in detail. These clinical observations demonstrate the importance of early diagnosis and selection of adequate therapy for a favorable outcome of the disease.
The Mapping of Electronic Commerce Issues and Consumer Protection Policy in Indonesia
Authors: Mubarok Muhammad Mufti
Published: August 2022

In the post-economic crisis in 1998, Indonesia experienced significant economic growth. Public consumption activities have become vulnerable due to open economic activities. In this case, the government has issued Law Number 8 of 1999 concerning Consumer Protection to protect consumers in fulfilling their needs. In September 2020, the Central Statistics Agency recorded that the millennial generation and generation Z dominate the population structure in Indonesia. This population structure also changes consumption patterns due to their lifestyle, including trends in electronic commerce or e-commerce. This study explores how consumer incidents relate to electronic commerce or e-commerce activities. It also strives to see the governmentâ€™s role in formulating policies related to consumer protection in electronic commerce or e-commerce. This study used the descriptive qualitative method of policy analysis. The findings of this study indicate that responsive policies are needed to minimize consumer incidents and strengthen cross-ministerial/institutional coordination related to consumer protection with ministries/agencies coordinatingÂ consumer protection.
Open Access Availability of Indias Scientific Research Funded by National and International Agencies
Authors: Deori Maya , Verma Manoj Kumar , Nazim Mohammad
Published: August 2022

Funding has become the most significant element of supportive action for research that has served the research community in numerous ways to improve the advancement and development of society. Scientific research in India is funded by many public and corporate sector institutions and autonomous organisations, NGOs, and regional and international agencies. However, access to publicly funded scientific research literature has been an essential issue of debate among the advocates of the Open Access (OA) movement during the last two decades. This study maps OA availability to India’s research publications funded by national and international agencies. The study applied a scientometric approach using the Scopus database to identify funding research publications available in the OA domain. The findings revealed that 570320 research articles were published by the Indian researchers during 2016-to 2020, of which 150638 (26.41 %) were produced with the financial support of different national and international funding agencies. Of the funded research publications, 44166 (29.32 %) articles were freely available OA to the public with no or fewer restrictions for reuse. Most of the funded research literature is available via green routes of OA, followed by gold and bronze OA. The study also showed that Horizon 2020 and the Ministry of Science, ICT, and Future Planning are the primary funding sources for researchers in India during study period. The study’s findings are helpful for researchers and policymakers to promote OA availability of funded research to researchers for advancing the country’s scientific progress.
Assessment of Students Faculty Satisfaction A Case Study of Punjab Agricultural University Library Facilities
Authors: Kaur Kulveen , Kathuria Kiran
Published: August 2022

Libraries must provide supportive environments and unhindered services to their users to support their academic well-being. A survey of 202 Punjab Agricultural University Library users was conducted to determine users’ satisfaction with the library webpage, library resources, infrastructure facilities, and library services. The study found differences in the satisfaction level and awareness of library services and facilities among the undergraduate, graduate, research scholars and faculty users. A compulsory credit-based course exists for postgraduate students only, leaving the other users uninformed about the services and facilities offered by the library. It was discovered that a robust ICT infrastructure is required since most of the users assessed the ICT infrastructure as ‘average’. Data collected was analysed using Statistical Package for Social Science (SPSS).
Information Spectrum over Twelve Public Teaching Universities in Indonesia
Authors: Suprapto Nadi , Setyarsih Woro , Mubarok Husni
Published: August 2022

This paper gives an information spectrum of public teaching universities in Indonesia as viewed from their publication during 2000-2019. The data were collected through the Scopus database and then analysed based on the number of documents, language, author affiliation, document type, source type, source title, top authors, top citations, co-authorship, and international collaboration. The results indicated that the number of publications until 2019 was 11,993 documents. In the period 2016-2019, publication stretches have begun to appear, and there has been a significant increase in the number of conference proceedings as the primary source of publication. The publication’s subject area was dominated by physics and astronomy, engineering, and social sciences, with English being the primary language of communication. Authors from Universitas Negeri Malang (UM), Universitas Pendidikan Indonesia (UPI), and Universitas Negeri Yogyakarta (UNY) dominated the output of public teaching universities in Indonesia. Top citations from documents produced were dominated by UNNES, which collaborates a lot through World Class Professor (WCP). Co-citation, co-authorship, and co-occurrences network visualisation were also illustrated to complete the information of top authors and top citations in this study. The most collaborated authors of public-teaching universities were Malaysia, the USA, Australia, Japan, and Taiwan. Some future considerations were also illustrated as the recommendation of this study to increase the performance of publications among public teaching universities.
The moderate‐intensity continuous exercise maintains renal blood flow and does not impair the renal function
Authors: Kawakami Shotaro , Yasuno Tetsuhiko , Kawakami Saki , Ito Ai , Fujimi Kanta , Matsuda Takuro , Nakashima Shihoko , Masutani Kosuke , Uehara Yoshinari , Higaki Yasuki , Michishita Ryoma
Published: August 2022

Exercise is restricted for individuals with reduced renal function because exercising reduces blood flow to the kidneys. Safe and effective exercise programs for individuals with reduced renal function have not yet been developed. We previously examined the relationship between exercise intensity and renal blood flow (RBF), revealing that moderate‐intensity exercise did not reduce RBF. Determining the effects of exercise duration on RBF may have valuable clinical applications. The current study examined the effects of a single bout of continuous exercise at lactate threshold (LT) intensity on renal hemodynamics. Eight adult males participated in this study. Participants underwent 30 min of aerobic exercise at LT intensity using a cycle ergometer. Evaluation of renal hemodynamics was performed before and after exercise, in the recovery phase using ultrasound echo. Furthermore, blood and urine samplings were conducted before and after exercise, in the recovery phase. Compared with resting, RBF was not significantly changed immediately after continuous exercise (319 ± 102 vs. 308 ± 79 ml/min; p = 0.976) and exhibited no significant changes in the recovery phase. Moreover, urinary kidney injury molecule‐1 (uKIM‐1) level exhibited no significant change immediately after continuous exercise (0.52 ± 0.20 vs. 0.46 ± 0.27 μg/g creatinine; p = 0.447). In addition, the results revealed no significant change in urinary uKIM‐1 in 60‐min after exercise. Other renal injury biomarkers exhibited a similar pattern. These findings indicate that a single bout of moderate‐intensity continuous exercise maintains RBF and does not induce renal injury.