bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of Void Detection Beneath Concrete Pavement Panels through Numerical Simulation
Authors: Yuan Jie , Jiao Huacheng , Wu Biao , Liu Fei , Li Wenhao , Du Hao , Li Jie
Published: June 2024

In the structure of composite pavement, the formation of voids beneath concrete panels poses significant risks to structural integrity and operational safety. Ground-Penetrating Radar (GPR) detection serves as an effective method for identifying voids beneath concrete pavement panels. This paper focuses on analyzing the morphological features of GPR echo signals. Leveraging the GprMax numerical simulation software, a numerical simulation model for void conditions in concrete pavement is established by setting reasonable pavement structure parameters, signal parameters, and model space parameters. The reliability of the numerical simulation model is validated based on field data from full-scale test sites with pre-fabricated voids. Various void conditions, including different void thicknesses, sizes, shapes, and filling mediums, are analyzed. The main conclusions of the study are as follows: the correlation coefficient between measured and simulated signals is above 0.8; a noticeable distinction exists between echo signals from intact and voided structures; signals exhibit similar phase and time delays for different void thicknesses and sizes but significant differences are observed in the A-scan signal intensity, the signal intensity, and the width of the B-scan signal; the impact of void shape on GPR echo signals mainly manifests in the variation of void thickness at different measurement points; and the relationship between the dielectric properties of the void-filling medium and the surrounding environment dictates the phase and time delay characteristics of the echo signal.
Pix2Pix-Assisted Beijing Hutong Renovation Optimization Method: An Application to the UTCI and Thermal and Ventilation Performance
Authors: Wu Rui , Huang Ming , Yang Zhenqing , Zhang Lili , Wang Lei , Huang Wei , Zhu Yongqiang
Published: June 2024

In response to the issues of low outdoor thermal comfort and poor ventilation environment in Beijing Hutong, this paper proposes a rapid intelligent optimization method combining Pix2Pix (Image-to-Image Translation with Conditional Adversarial Networks) with a genetic algorithm. Firstly, the architectural types of the research objects are highly refined and summarized into four traditional building types. Then, they are placed in the site with open spaces in a certain proportion, and a multi-objective optimization model for the UTCI (Universal Thermal Climate Index) and building area is constructed using a genetic algorithm, generating and iteratively optimizing the spatial layout of the building population. Finally, Pix2Pix is used to learn and train a large number of Hutong combination samples, rapidly generating the UTCI and ventilation results, which serve as the optimization objectives to obtain the optimal solution set for Hutong spatial forms. Compared with traditional empirical design methods, this method allows for a rapid and efficient traversal of vast solution spaces, intelligently generating Hutong renovation schemes that balance cultural heritage and healthy comfort. The research results demonstrate that this method can quickly find (26.4 times faster than traditional performance simulation methods) that the reasonable proportions of Siheyuan, Sanheyuan, Erheyuan, new buildings, and empty spaces in the Da Yuan Hutong in Beijing should be controlled at 11.8%, 16.9%, 23.8%, 33.8%, and 13.7%, respectively. Meanwhile, the building density should be maintained between 0.5 and 0.58, and the floor area ratio should be kept between 0.96 and 1.14. This significantly improves outdoor comfort, enhances the living environment of the Hutong, and promotes sustainable urban development.
Evolving Precision First-Line Systemic Treatment for Patients with Unresectable Non-Small Cell Lung Cancer
Authors: Li Tianhong , Ma Weijie , Al-Obeidi Ebaa
Published: June 2024

First-line systemic therapy for patients with advanced or metastatic non-small cell lung cancer (NSCLC) has rapidly evolved over the past two decades. First, molecularly targeted therapy for a growing number of gain-of-function molecular targets has been shown to improve progression-free survival (PFS) and overall survival (OS) with favorable toxicity profiles compared to platinum-containing chemotherapy and can be given as first-line systemic therapy in ~25% of patients with NSCLC. Actionable genetic alterations include EGFR, BRAF V600E, and MET exon 14 splicing site-sensitizing mutations, as well as ALK-, ROS1-, RET-, and NTRK-gene fusions. Secondly, inhibitors of programmed cell death protein 1 or its ligand 1 (PD-1/L1) such as pembrolizumab, atezolizumab, or cemiplimab monotherapy have become a standard of care for ~25% of patients with NSCLC whose tumors have high PD-L1 expression (total proportion score (TPS) ≥50%) and no sensitizing EGFR/ALK alterations. Lastly, for the remaining ~50% of patients who are fit and whose tumors have no or low PD-L1 expression (TPS of 0–49%) and no sensitizing EGFR/ALK aberrations, platinum-containing chemotherapy with the addition of a PD-1/L1 inhibitor alone or in combination of a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor improves PFS and OS compared to chemotherapy alone. The objectives of this review are to summarize the current data and perspectives on first-line systemic treatment in patients with unresectable NSCLC and propose a practical algorithm for implementing precision biomarker testing at diagnosis.
A Prospective Observational Cohort Study for Newly Diagnosed Osteosarcoma Patients in the UK: ICONIC Study Initial Results
Authors: Childs Alexa , Gerrand Craig , Brennan Bernadette , Young Robin , Rankin Kenneth S. , Parry Michael , Stevenson Jonathan , Flanagan Adrienne M. , Taylor Rachel M. , Fern Lorna , Heymann Dominique , Vance Filipa , Sherriff Jenny , Singh Saurabh , Begum Rubina , Forsyth Sharon L. , Reczko Krystyna , Sparksman Kate , Wilson William , Strauss Sandra J.
Published: June 2024

There has been little change to the standard treatment for osteosarcoma (OS) over the last 25 years and there is an unmet need to identify new biomarkers and novel therapeutic approaches if outcomes are to improve. Furthermore, there is limited evidence on the impact of OS treatment on patient-reported outcomes (PROs). ICONIC (Improving Outcomes through Collaboration in Osteosarcoma; NCT04132895) is a prospective observational cohort study recruiting newly diagnosed OS patients across the United Kingdom (UK) with matched longitudinal collection of clinical, biological, and PRO data. During Stage 1, which assessed the feasibility of recruitment and data collection, 102 patients were recruited at 22 sites with representation from patient groups frequently excluded in OS studies, including patients over 50 years and those with less common primary sites. The feasibility of collecting clinical and biological samples, in addition to PRO data, has been established and there is ongoing analysis of these data as part of Stage 2. ICONIC will provide a unique, prospective cohort of newly diagnosed OS patients representative of the UK patient population, with fully annotated clinical outcomes linked to molecularly characterised biospecimens, allowing for comprehensive analyses to better understand biology and develop new biomarkers and novel therapeutic approaches.
Mediating Effects of Self-Efficacy and Illness Perceptions on Mental Health in Men with Localized Prostate Cancer: A Secondary Analysis of the Prostate Cancer Patient Empowerment Program (PC-PEP) Randomized Controlled Trial
Authors: MacDonald Cody , Ilie Gabriela , Kephart George , Rendon Ricardo , Mason Ross , Bailly Greg , Bell David , Patil Nikhilesh , Bowes David , Wilke Derek , Kokorovic Andrea , Rutledge Robert D. H.
Published: June 2024

Understanding how interventions reduce psychological distress in patients with prostate cancer is crucial for improving patient care. This study examined the roles of self-efficacy, illness perceptions, and heart rhythm coherence in mediating the effects of the Prostate Cancer Patient Empowerment Program (PC-PEP) on psychological distress compared to standard care. In a randomized controlled trial, 128 patients were assigned to either the PC-PEP intervention or standard care. The PC-PEP, a six-month program emphasizing daily healthy living habits, included relaxation and stress management, diet, exercise, pelvic floor muscle exercises, and strategies to improve relationships and intimacy, with daily activities supported by online resources and live sessions. Participants in the intervention group showed significant improvements in self-efficacy and specific illness perceptions, such as personal control and emotional response, compared to the control group. These factors mediated the relationship between the intervention and its psychological benefits, with self-efficacy accounting for 52% of the reduction in psychological distress. No significant differences in heart rhythm coherence were observed. This study highlights the critical role of self-efficacy and illness perceptions in enhancing psychological health in prostate cancer patients through the PC-PEP. The results underscore this program’s effectiveness and the key mechanisms through which it operates. Given the high rates of distress among men undergoing prostate cancer treatments, these findings emphasize the importance of integrating the PC-PEP into clinical practice. The implementation of the PC-PEP in clinical settings can provide a structured approach to reducing psychological distress and improving overall patient well-being.
A Systematic Review of Cost-Effectiveness Studies on Gastric Cancer Screening
Authors: Lewis Diedron , Jimenez Laura , Mansour Manel Haj , Horton Susan , Wong William W. L.
Published: June 2024

Gastric cancer (GC) poses notable economic and health burdens in settings where the incidence of disease is prevalent. Some countries have established early screening and treatment programs to address these challenges. The objectives of this systematic review were to summarize the cost-effectiveness of gastric cancer screening presented in the literature and to identify the critical factors that influence the cost-effectiveness of screening. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Economic evaluation studies of gastric cancer screening were reviewed from SCOPUS and PubMed. The Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) was used to assess the quality of reporting presented in the selected articles. Only primary economic evaluation studies addressing the cost-effectiveness, cost–utility, and cost–benefit of gastric cancer screening were selected. Two reviewers scrutinized the selected articles (title, abstract, and full text) to determine suitability for the systematic review based on inclusion and exclusion criteria. Authors’ consensus was relied on where disagreements arose. The main outcome measures of concern in the systematic review were cost, effectiveness (as measured by either quality-adjusted life years (QALY) or life-years saved (LYS)), and incremental cost-effectiveness ratio (ICER) of screening versus either no screening or an alternative screening method. Thirty-one studies were selected for the final review. These studies investigated the cost-effectiveness of GC screening based on either primary, secondary, or a combination of primary and secondary interventions. The main primary intervention was Helicobacter pylori (Hp) screening with eradication, while the main secondary intervention was endoscopic screening. Cost-effectiveness was evaluated against no screening or screening using an alternative method in both observational and model-based studies. Screening was mainly cost-effective in Asian countries or their diasporas where the prevalence of GC was high. GC screening was generally not cost-effective among Western countries. GC screening can be cost-effective, but cost-effectiveness is dependent on context-specific factors, including geographical location, the prevalence of GC in the local population, and the screening tool adopted. However, there is benefit in targeting high-risk population groups in Asian countries and their diaspora for GC screening.
State-of-the-Art and New Treatment Approaches for Spinal Cord Tumors
Authors: Kumawat Chetan , Takahashi Toshiyuki , Date Isao , Tomita Yousuke , Tanaka Masato , Arataki Shinya , Komatsubara Tadashi , Flores Angel O. P. , Yu Dongwoo , Jain Mukul
Published: June 2024

Spinal cord tumors, though rare, present formidable challenges in clinical management due to their intricate nature. Traditional treatment modalities like surgery, radiation therapy, and chemotherapy have been the mainstay for managing these tumors. However, despite significant advancements, challenges persist, including the limitations of surgical resection and the potential side effects associated with radiation therapy. In response to these limitations, a wave of innovative approaches is reshaping the treatment landscape for spinal cord tumors. Advancements in gene therapy, immunotherapy, and targeted therapy are offering groundbreaking possibilities. Gene therapy holds the potential to modify the genes responsible for tumor growth, while immunotherapy harnesses the body’s own immune system to fight cancer cells. Targeted therapy aims to strike a specific vulnerability within the tumor cells, offering a more precise and potentially less toxic approach. Additionally, novel surgical adjuncts are being explored to improve visualization and minimize damage to surrounding healthy tissue during tumor removal. These developments pave the way for a future of personalized medicine for spinal cord tumors. By delving deeper into the molecular makeup of individual tumors, doctors can tailor treatment strategies to target specific mutations and vulnerabilities. This personalized approach offers the potential for more effective interventions with fewer side effects, ultimately leading to improved patient outcomes and a better quality of life. This evolving landscape of spinal cord tumor management signifies the crucial integration of established and innovative strategies to create a brighter future for patients battling this complex condition.
Use of Vascular Shunt at the Time of Pancreatectomy with Venous Resection: A Systematic Review
Authors: Libia Annarita , Marchese Tiziana , D’Ugo Stefano , Piscitelli Prisco , Castellana Fabio , Clodoveo Maria Lisa , Zupo Roberta , Spampinato Marcello Giuseppe
Published: June 2024

Background: The rising diffusion of vascular resections during complex pancreatectomy for malignancy, for both oncological and technical matters, brought with it the use of vascular shunts, either temporary or definitive, to prevent bowel congestion and liver ischemia. This study aimed to systematically review the literature on the technical feasibility of vascular shunts during advanced pancreatic surgery, analyzing intraoperative and postoperative outcomes. Methods: A systematic literature search was performed on PubMed, Scopus, Web of Science, and the Cochrane Library Central, according to PRISMA guidelines. Studies published before 2006 were excluded, considering the lack of a standardized definition of locally advanced pancreatic cancer. The main outcomes evaluated were the overall complication rate and shunt patency. Results: Among 789 papers retrieved from the database search, only five fulfilled the inclusion criteria and were included in the review, amounting to a total of 145 patients undergoing a shunt creation at the time of pancreatectomy. Pancreatic adenocarcinoma (PDAC) was found to be the most common diagnosis and pancreaticoduodenectomy was the main surgical procedure, accounting for 88% and 83% of the overall cohort, respectively. The distal splenorenal shunt was the most performed. Overall, 44 out of 145 patients (30%) experienced postoperative complications; the long-term patency of definitive shunts was 83% (110 out of 120 patients). Conclusions: An increasing number of patients with borderline resectable or locally advanced PDAC are becoming amenable to resection and shunt creation may facilitate vascular resection with clear margins, becoming a valid tool of modern pancreatic surgery.
Combined PIVKA II and Vimentin-Guided EMT Tracking in Pancreatic Adenocarcinoma Combined Biomarker-Guided EMT Tracking in PDAC
Authors: Farina Antonella , Viggiani Valentina , Cortese Francesca , Moretti Marta , Tartaglione Sara , Angeloni Antonio , Anastasi Emanuela
Published: June 2024

“Background/Aim”: the current inability to diagnose Pancreatic Cancer Adenocarcinoma (PDAC) at an early stage strongly influences therapeutic strategies. Protein Induced by Vitamin K Absence (PIVKA II) showed an accurate diagnostic performance for PDAC. Since circulating PIVKA II has been recently associated with pancreatic origin cells with Vimentin, an epithelial-to-mesenchymal transition (EMT) early activation marker, the aim of this study was to investigate in vivo the combination between the two proteins. “Materials and Methods”: we assayed the presence of PIVKA II and Vimentin proteins by using different diagnostic methods. A total of 20 PDAC patients and 10 healthy donors were tested by Western Blot analysis; 74 PDAC patient and 46 healthy donors were assayed by ECLIA and Elisa. “Results”: Western Blot analysis showed the concomitant expression of PIVKA II and Vimentin in PDAC patient sera. Immunometric assay performed on a larger cohort of patients demonstrated that 72% of PIVKA II-positive PDAC patients were Vimentin-positive. Additionally, in a group of PDAC patients with PIVKA II levels ≥2070 ng/mL, the percentage of Vimentin-positive subjects reached 84%. “Conclusion“: the association between PIVKA II protein and the EMT suggests that this molecule could be considered a marker of the acquisition of an aggressive phenotype.
Defining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration
Authors: Park Margaret A. , Whelan Christopher J. , Ahmed Sabeen , Boeringer Tabitha , Brown Joel , Crowder Sylvia L. , Gage Kenneth , Gregg Christopher , Jeong Daniel K. , Jim Heather S. L. , Judge Andrew R. , Mason Tina M. , Parker Nathan , Pillai Smitha , Qayyum Aliya , Rajasekhara Sahana , Rasool Ghulam , Tinsley Sara M. , Schabath Matthew B. , Stewart Paul , West Jeffrey , McDonald Patricia , Permuth Jennifer B.
Published: June 2024

For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance and poorer response to treatment, poor quality of life, and reduced survival. Unfortunately, there are no effective therapeutic interventions to completely reverse cancer cachexia and no FDA-approved pharmacologic agents; hence, new approaches are urgently needed. In May of 2022, researchers and clinicians from Moffitt Cancer Center held an inaugural retreat on CAC that aimed to review the state of the science, identify knowledge gaps and research priorities, and foster transdisciplinary collaborative research projects. This review summarizes research priorities that emerged from the retreat, examples of ongoing collaborations, and opportunities to move science forward. The highest priorities identified include the need to (1) evaluate patient-reported outcome (PRO) measures obtained in clinical practice and assess their use in improving CAC-related outcomes; (2) identify biomarkers (imaging, molecular, and/or behavioral) and novel analytic approaches to accurately predict the early onset of CAC and its progression; and (3) develop and test interventions (pharmacologic, nutritional, exercise-based, and through mathematical modeling) to prevent CAC progression and improve associated symptoms and outcomes.
Differential Serum Peptidomics Reveal Multi-Marker Models That Predict Breast Cancer Progression
Authors: AlZaabi Adhari , Piccolo Stephen , Graves Steven , Hansen Marc
Published: June 2024

Here, we assess how the differential expression of low molecular weight serum peptides might predict breast cancer progression with high confidence. We apply an LC/MS-MS-based, unbiased ‘omics’ analysis of serum samples from breast cancer patients to identify molecules that are differentially expressed in stage I and III breast cancer. Results were generated using standard and machine learning-based analytical workflows. With standard workflow, a discovery study yielded 65 circulating biomarker candidates with statistically significant differential expression. A second study confirmed the differential expression of a subset of these markers. Models based on combinations of multiple biomarkers were generated using an exploratory algorithm designed to generate greater diagnostic power and accuracy than any individual markers. Individual biomarkers and the more complex multi-marker models were then tested in a blinded validation study. The multi-marker models retained their predictive power in the validation study, the best of which attained an AUC of 0.84, with a sensitivity of 43% and a specificity of 88%. One of the markers with m/z 761.38, which was downregulated, was identified as a fibrinogen alpha chain. Machine learning-based analysis yielded a classifier that correctly categorizes every subject in the study and demonstrates parameter constraints required for high confidence in classifier output. These results suggest that serum peptide biomarker models could be optimized to assess breast cancer stage in a clinical setting.
Sex- and Age-Associated Differences in Genomic Alterations among Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Authors: Kimbrough ErinMarie O. , Marin-Acevedo Julian A. , Drusbosky Leylah M. , Mooradian Ariana , Zhao Yujie , Manochakian Rami , Lou Yanyan
Published: June 2024

Genomic mutations impact non-small cell lung cancer (NSCLC) biology. The influence of sex and age on the distribution of these alterations is unclear. We analyzed circulating-tumor DNA from individuals with advanced NSCLC from March 2018 to October 2020. EGFR, KRAS, ALK, ROS1, BRAF, NTRK, ERBB2, RET, MET, PIK3CA, STK11, and TP53 alterations were assessed. We evaluated the differences by sex and age (<70 and ≥70) using Fisher’s exact test. Of the 34,277 samples, 30,790 (89.83%) had a detectable mutation and 19,923 (58.12%) had an alteration of interest. The median age of the ctDNA positive population was 69 (18–102), 16,756 (54.42%) were female, and 28,835 (93.65%) had adenocarcinoma. Females had more alterations in all the assessed EGFR mutations, KRAS G12C, and ERBB2 ex20 ins. Males had higher numbers of MET amp and alterations in STK11 and TP53. Patients <70 years were more likely to have alterations in EGFR exon 19 del/exon 20 ins/T790M, KRAS G12C/D, ALK, ROS1, BRAF V600E, ERBB2 Ex20ins, MET amp, STK11, and TP53. Individuals ≥70 years were more likely to have alterations in EGFR L861Q, MET exon 14 skipping, and PIK3CA. We provided evidence of sex- and age-associated differences in the distribution of genomic alterations in individuals with advanced NSCLC.
Impact of Co-Fed Hydrogen on High Conversion Propylene Aromatization on H-ZSM-5 and Ga/H-ZSM-5
Authors: Russell Christopher K. , Rockey Josiah L. , Hanna Rebecca N. , Miller Jeffrey T.
Published: June 2024

The expanded production of shale gas has increased the desire for developing methods for converting light alkanes, especially propane and ethane, into aromatic compounds (i.e., benzene, toluene, and xylene) for petrochemicals and fuels. The Cyclar process is one example of an industrial process that has been demonstrated for the conversion of butane to aromatics; however, the conversion of lower molecular weight alkanes remains elusive. A multi-step process for the conversion of light alkanes to aromatics may be developed, where the first stage converts light alkanes into olefins and hydrogen, and the second stage converts olefins into aromatics. However, to determine the viability of this process, a better understanding of the performance of olefin aromatization in the presence of equimolar hydrogen is necessary. Herein, H-ZSM-5 and Ga-modified H-ZSM-5 are compared for propylene aromatization in the presence and absence of equimolar hydrogen at 1.9 kPa and 50 kPa partial pressures. The presence of H2 has no impact on the product distribution with H-ZSM-5 at either pressure. At 1.9 kPa with Ga/H-ZSM-5, similar product distributions are observed regardless of the presence or absence of H2 since Ga is not sufficiently active for hydrogenation to inhibit aromatics formation. However, at 50 kPa of H2 with Ga/H-ZSM-5, there is an increased selectivity to C4 products and a decrease in toluene and xylene selectivities at high conversions (i.e., χ > 80%), suggesting that aromatic dehydrogenation of cyclic hydrocarbons has been suppressed.
Study on Novel SCR Catalysts for Denitration of High Concentrated Nitrogen Oxides and Their Reaction Mechanisms
Authors: Yu Bo , Liu Xingyu , Wu Shufeng , Yang Heng , Zhou Shuran , Yang Li , Liu Fang
Published: June 2024

With the rapid development of industrialization, the emission of nitrogen oxides (NOx) has become a global environmental issue. Uranium is the primary fuel used in nuclear power generation. However, the production of uranium, typically based on the uranyl nitrate method, usually generates large amounts of nitrogen oxides, particularly NO2, with concentrations in the exhaust gas exceeding 10,000 ppm. High concentrations of nitrogen dioxide are also produced during silver electrolysis processing and the treatment of waste electrolyte solutions. Traditional V-W/TiO2 NH3-SCR catalysts typically exhibit high catalytic activity at temperatures ranging from 300 to 400 °C, under conditions of low NOx concentrations and high gas hourly space velocity. However, their performance is not satisfying when reducing high concentrations of NO2. This study aims to optimize the traditional V-W/TiO2 catalysts to enhance their catalytic activity under conditions of high NO2 concentrations (10,000 ppm) and a wide temperature range (200–400 °C). On the basis of 3 wt% Mo/TiO2, various loadings of V2O5 were selected, and their catalytic activities were tested. Subsequently, the optimal ratios of active component vanadium and additive molybdenum were explored. Simultaneously, doping with WO3 for modification was selected in the V-Mo/TiO2 catalyst, followed by activity testing under the same conditions. The results show that: the NOx conversion rates of all five catalysts increase with temperature at range of 200–400 °C. Excessive loading of MoO3 decreased the catalytic performance, with 5 wt% being the optimal loading. The addition of WO3 significantly enhanced the low-temperature activity of the catalysts. When the loadings of WO3 and MoO3 were both 3 wt%, the catalyst exhibited the best denitrification performance, achieving a NOx conversion rate of 98.8% at 250 °C. This catalyst demonstrates excellent catalytic activity in reducing very high concentration (10,000 ppm) NO2, at a wider temperature range, expanding the temperature range by 50% compared to conventional SCR catalysts. Characterization techniques including BET, XRD, XPS, H2-TPR, and NH3-TPD were employed to further study the evolution of the catalyst, and the promotional mechanisms are explored. The results revealed that the proportion of chemisorbed oxygen (Oα) increased in the WO3-modified catalyst, exhibiting lower V reduction temperatures, which are favorable for low-temperature denitrification activity. NH3-TPD experiments showed that compared to MoOx species, surface WOx species could provide more acidic sites, resulting in stronger surface acidity of the catalyst.
Thymosin β4 and β10 Expression in Human Organs during Development: A Review
Authors: Faa Gavino , Messana Irene , Coni Pierpaolo , Piras Monica , Pichiri Giuseppina , Piludu Marco , Iavarone Federica , Desiderio Claudia , Vento Giovanni , Tirone Chiara , Manconi Barbara , Olianas Alessandra , Contini Cristina , Cabras Tiziana , Castagnola Massimo
Published: June 2024

This review summarizes the results of a series of studies performed by our group with the aim to define the expression levels of thymosin β4 and thymosin β10 over time, starting from fetal development to different ages after birth, in different human organs and tissues. The first section describes the proteomics investigations performed on whole saliva from preterm newborns and gingival crevicular fluid, which revealed to us the importance of these acidic peptides and their multiple functions. These findings inspired us to start an in-depth investigation mainly based on immunochemistry to establish the distribution of thymosin β4 and thymosin β10 in different organs from adults and fetuses at different ages (after autopsy), and therefore to obtain suggestions on the functions of β-thymosins in health and disease. The functions of β-thymosins emerging from these studies, for instance, those performed during carcinogenesis, add significant details that could help to resolve the nowadays so-called “β-thymosin enigma”, i.e., the potential molecular role played by these two pleiotropic peptides during human development.
Do Moral Emotions Interact with Self-Control and Unstructured Socializing in Explaining Rule-Breaking Behavior Committed Together with Friends?
Authors: Schön Sara-Marie , Daseking Monika
Published: June 2024

Previous research has shown that moral emotions interact with self-control and unstructured socializing in explaining rule-breaking behavior. High levels of moral emotions appear to weaken the effects of both self-control and unstructured socializing, in explaining rule-breaking behavior. The current study examined whether these interactions also affect rule-breaking behavior that is explicitly committed with friends. In addition, three operationalizations of moral emotions were distinguished. Data were collected from N = 169 adolescents (54% female; mean = 14.95 years; SD = 1.7) using a self-report questionnaire battery. Results indicate that high levels of anticipated emotions in moral conflicts (AEMC) attenuate the effect of low self-control on one’s own rule-breaking behavior. In contrast, high levels of both guilt- and shame-proneness enhanced the effect of unstructured socializing on one’s own and rule-breaking with friends. The limitations of the study, ideas for future research, and practical implications are also discussed.
Exploring Diagnostic Priorities: The Role of Colonic Manometry in Evaluating Pediatric Patients with Intractable Idiopathic Constipation Prior to Sacral Nerve Stimulation
Authors: Dorfman Lev , El-Chammas Khalil , Singh Azadvir , Fei Lin , Mansi Sherief , Santucci Neha R. , Kaul Ajay
Published: June 2024

Background: Despite the limited understanding of its precise mechanism of action, sacral nerve stimulation (SNS) has proven to be helpful for pediatric patients with constipation, particularly those with fecal incontinence. It is unclear whether the outcome of SNS is impacted by normal or abnormal colonic motility. Our study aimed to determine whether colonic manometry results had an impact on the outcome of SNS as a treatment in pediatric patients with refractory idiopathic constipation. Methods: Electronic medical records of patients with idiopathic constipation who underwent colonic manometry and SNS placement at our center over 6 years were reviewed. A comparison of post-SNS outcomes was performed between patients with normal and abnormal colonic manometry studies. Results: Twenty patients [12 (60%) females, median age of 10.2 years] met inclusion criteria, with fecal incontinence in 12 (60%) and abnormal colonic manometry in 6 (30%). Significantly more patients had an improvement in fecal incontinence following SNS placement (p = 0.045). There were no significant differences in post-SNS constipation outcome measures between patients with normal versus abnormal colonic manometry. Conclusions: Colonic manometry did not help with patient selection for those being considered for SNS therapy. Our findings do not support performing colonic manometry as a screening prior to SNS placement.
Association of Umbilical Cord Perilipin 2 Levels with Neonatal Anthropometric Measurements in Infants of Diabetic Mothers
Authors: Celik Kiymet , Ozkan Zarif Nurten , Ozen Kucukcetin Ikbal , Arayici Sema , Kihtir Zeynep , Unver Tuhan Hale , Ongun Hakan
Published: June 2024

Background: Perilipin 2 (PLIN2) is a protein that contributes to the formation and stability of lipid droplets. It has been associated with the development of several diseases, particularly related to glucose and lipid metabolism. In infants of diabetic mother (IDM), fetal hyperinsulinaemia leads to increased adipose tissue and macrosomia. The aim of this study was to investigate the relationship between PLIN2 levels and anthropometric measurements in the IDM and to investigate the relationship between PLIN2 levels and IGF-1, IGF-2 and leptin levels. Methods: The study group consisted of IDMs, while the control group consisted of infants born to non-diabetic mother, matched for gestational week and gender. Cord blood samples were collected from all patients to determine PLIN2, IGF-1, IGF-2 and leptin levels. Anthropometric measurements were taken for all patients at birth. Results: There were no differences between the groups in birth weight, birth length, head circumference and body mass index (BMI), but middle arm circumference, triceps, biceps, subscapular and suprailiac skinfold thickness were significantly higher in the IDM. While PLIN2, IGF-1, IGF-2 and leptin levels were similar between groups, there was a strong correlation between PLIN2 levels and IGF-2 and leptin levels. Conclusions: Even if IDMs were not macrosomic, the presence of high subcutaneous adipose tissue was not associated with PLIN2.
Understanding Adolescent Mental Health in the COVID-19 Era: A Psychodynamic Approach
Authors: Akın Aslı , Sarrar Lea
Published: June 2024

Objective: This cross-sectional, case-control study aimed to explore the psychodynamic characteristics that influenced adolescents’ mental health during the COVID-19 pandemic. Methods: Personality structure impairments, psychodynamic conflicts, defense styles, and mental health issues were examined using the OPD-Structure- and Conflict-Questionnaires, the Defense Style Questionnaire, and the Patient Health Questionnaire in adolescents before (n = 288) and after (n = 451) the COVID-19 pandemic in Germany. Results: Adolescents with mental health issues exhibited greater impairments in personality structure, more immature defense styles, and higher levels of psychodynamic conflicts both before and after the pandemic onset. Comparisons between pre-pandemic and pandemic samples indicated a lower level of the conflict of taking care of oneself versus being cared for in passive mode among adolescents during the pandemic. In-depth analysis of adolescents with mental health issues from the pandemic group revealed significant associations between personality structure impairments and a maladaptive defense style with somatoform, depressive, anxiety, eating, and alcohol use disorders. Conclusion: The findings provide clinically relevant insights into the psychodynamic factors that contributed to the psychological vulnerability of adolescents during the COVID-19 pandemic. These insights can guide the development of targeted psychodynamic interventions to support adolescents’ mental health in similar future crises.
Medical Complexity of Children with Special Healthcare Needs and Healthcare Experiences
Authors: Yun Hye-Jung , Parker M. L. , Wilson Cynthia B. , Cui Ming
Published: June 2024

The rising prevalence of CSHCN has led to significant challenges for caregivers, particularly mothers, who face difficulties from caregiving demands and managing complex healthcare interactions. The objective of this study was to examine the association between the medical complexity of CSHCN and the healthcare experiences of their mothers while exploring the influence of sociodemographic factors on these associations. The study utilized data from the 2016–2020 National Survey of Children’s Health (NSCH), involving 17,434 mothers of CSHCN. Mothers provided information on the medical complexity of CSHCN, healthcare experiences (care coordination, family-centered care, and shared decision-making), and sociodemographic information (race, community, insurance, child sex, age, and federal poverty level). Results from multiple regressions revealed that greater medical complexity was associated with more negative healthcare experiences. Minoritized mothers, those in rural areas, and families with lower income reported lower levels of family-centered care, indicating significant disparities. Additionally, the negative association between medical complexity and healthcare experiences was pronounced for White families and those with private insurance compared to minoritized families and those with public insurance. This study highlights the necessity for targeted interventions to improve care coordination, family-centered care, and shared decision-making, emphasizing the need for a comprehensive, family-centered approach to address healthcare disparities and promote health equity for CSHCN and their families.
Management of Paediatric Cardiac Arrest due to Shockable Rhythm—A Simulation-Based Study at Children’s Hospitals in a German Federal State
Authors: Mand Nadine , Hoffmann Marieke , Schwalb Anja , Leonhardt Andreas , Sassen Martin , Stibane Tina , Maier Rolf Felix , Donath Carolin
Published: June 2024

(1) Background: To improve the quality of emergency care for children, the Hessian Ministry for Social Affairs and Integration offered paediatric simulation-based training (SBT) for all children’s hospitals in Hesse. We investigated the quality of paediatric life support (PLS) in simulated paediatric resuscitations before and after SBT. (2) Methods: In 2017, a standardised, high-fidelity, two-day in-house SBT was conducted in 11 children’s hospitals. Before and after SBT, interprofessional teams participated in two study scenarios (PRE and POST) that followed the same clinical course of apnoea and cardiac arrest with a shockable rhythm. The quality of PLS was assessed using a performance evaluation checklist. (3) Results: 179 nurses and physicians participated, forming 47 PRE and 46 POST interprofessional teams. Ventilation was always initiated. Before SBT, chest compressions (CC) were initiated by 87%, and defibrillation by 60% of teams. After SBT, all teams initiated CC (p = 0.012), and 80% defibrillated the patient (p = 0.028). The time to initiate CC decreased significantly (PRE 123 ± 11 s, POST 76 ± 85 s, p = 0.030). (4) Conclusions: The quality of PLS in simulated paediatric cardiac arrests with shockable rhythm was poor in Hessian children’s hospitals and improved significantly after SBT. To improve children’s outcomes, SBT should be mandatory for paediatric staff and concentrate on the management of shockable rhythms.
Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants—Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound
Authors: Cerar Sandra , Vurzer Lara , Šalamon Aneta Soltirovska , Kornhauser Cerar Lilijana , Trdan Matevž , Robek Domen , Perme Tina , Biček Ajda , Oblak Adrijana , Marc Janja , Černe Darko , Erčulj Vanja , Grosek Štefan
Published: June 2024

Background: Significant improvement in neonatal care has enabled increasing survival of preterm infants. Metabolic bone disease of prematurity is often overlooked due to other comorbidities of preterm birth. The best approach is screening and prevention of the disease in high-risk infants such as preterm infants. Aim: We followed up the clinical, radiological, and serum biochemical markers of metabolic bone disease in extremely preterm infants (<28 weeks of gestation). The clinical applicability and validation of C-terminal telopeptide of type I collagen (CTX-I) as a novel bone turnover marker were assessed. Standard and novel biochemical bone turnover markers and quantitative ultrasound were compared. Method: Patients’ data were collected from medical records. Assessments of calcium, phosphate, alkaline phosphatase, bone-alkaline phosphatase, CTX-I, and quantitative ultrasound were prospectively performed twice in 42 extremely preterm infants at postmenstrual ages of 30–32 weeks and 36–40 weeks. Bone mineral density was measured by quantitative ultrasound. Conclusion: Phosphate, alkaline phosphatase, bone alkaline phosphatase, calcium, or ionized calcium are not related to gestational age, but bone mineral density, measured by quantitative ultrasound, is related. There is no correlation between standard and novel biochemical markers and quantitative ultrasound for the identification of metabolic bone disease.
Change of Adhesion Properties of Bioinspired Laser-Induced Periodic Nanostructures towards Cribellate Spider Nanofiber Threads by Means of Thin Coatings
Authors: Heitz Johannes , Buchberger Gerda , Baumgartner Werner , Meyer Marco , Weissbach Margret , Joel Anna-Christin , Brajnicov Simona , Palla-Papavlu Alexandra , Dinescu Maria
Published: June 2024

We investigated the effect of additional continuous functional coatings, which changed the hydrophilic–hydrophobic properties of the surface without heavily influencing the surface topography at the nanoscale, on the antiadhesive properties of bioinspired laser-induced periodic nanostructures. These nanostructures mimic the antiadhesive structures on the silk-combing area on the legs of cribellate spiders, the calamistrum. The thin films were deposited by matrix-assisted laser deposition and characterized by infrared spectroscopy, X-ray photoelectron spectroscopy, water contact angle measurements, and adhesion tests using capture threads from the cribellate spider webs. In all cases, the nanoripples were preserved and these structured surfaces showed lower adhesion forces compared to flat controls, although not significant. However, this effect was totally overwhelmed by the difference between the adhesion forces on surfaces with different chemical compositions. The largest adhesion forces were observed on hydrophilic surfaces and the lowest ones on hydrophobic surfaces. The fact that the antiadhesion between nanofibers and the nano-structured areas depends strongly on the chemical composition of the surface can be explained by the specific adhesion between individual chemical groups due to frequency dependencies in the theory of van der Waals forces. However, explaining these adhesion properties just by the categories “hydrophilic” or “hydrophobic” is oversimplified.
Analysis of Wear Vibration Behavior of Micro-Textured Coated Cemented Carbide Considering High-Order Scale
Authors: Tong Xin , Wang Shoumeng
Published: June 2024

In order to explore the influence of high-order micro-texture parameters on the friction, wear, and vibration characteristics of coated cemented carbide pin surfaces, expand the research field of textured coating modification processes. Firstly, a laser was used to prepare micro-texture on the surface of the cemented carbide pin, and AlCrN coating was carried out. The friction and wear test platform of the micro-textured physical vapor deposition (PVD)-coated cemented carbide and titanium alloy substrate was built, and the friction vibration and acoustic vibration signals were obtained as the main analysis media. Secondly, according to the characteristics of the test signal, three time-frequency images are analyzed and compared. The continuous wavelet transform (CWT) method with a better time-frequency analysis effect is selected. Finally, the characteristics and regularity of friction vibration and acoustic vibration are analyzed by using the gray mean of the CWT time-frequency image. The influence mechanism of high-order micro-texture parameters on the surface characteristics of coated cemented carbide pins was obtained. It is concluded that the high-order micro-texture is 1.58% higher than the traditional scale in the stability of friction vibration, 4.47% higher in the stability of acoustic vibration, and 13.16% lower in the friction force, which proves the progress of the size improvement. It provides a practical basis for the extension research of cemented carbide surface modification.
The Effect of Template Reset Operation on the Number of Crystals Precipitated at the Air–Solution Template Interface
Authors: Tumurbaatar Bolor-Uyanga , Amari Shuntaro , Takiyama Hiroshi
Published: June 2024

The application of template crystallization to developing novel crystalline materials has attracted attention. However, when the air–solution interface becomes the template interface and the target material crystallizes, new nucleation at the template interface is prevented, which is predicted to prevent the increase in the total number of crystals. In this study, we investigated the effect of operations that change the driving force at the air–solution template interface on the number of crystals at the interface. The number of crystals precipitated by changing the local supersaturation was investigated by a novel “template reset” operation, in which the concentration driving force near the template interface is changed by dissolving the crystals at the interface, once precipitated. The results showed that the number of crystals increased significantly after the template reset operation, and the particle size distribution was also improved. The temperature of the solution near the interface after the template reset operation was higher than that of the solution at the bottom of the petri dish and the prepared saturated solution, suggesting that the driving force of crystallization was higher.
Exploring Methane Storage Capacities of M2(BDC)2(DABCO) Sorbents: A Multiscale Computational Study
Authors: Huynh Nguyen Thi Xuan , Nguyen-Van Tue , Tran Nguyen Le Bao , Nghia Nguyen Van , Thanh Pham Ngoc
Published: June 2024

A promising solution for efficient methane (CH4) storage and transport is a metal–organic framework (MOF)-based sorbent. Hence, searching for potential MOFs like M2(BDC)2(DABCO) to enhance the CH4 storage capacity in both gravimetric and volumetric uptakes is essential. Herein, we systematically elucidate the adsorption of CH4 in M2(BDC)2(DABCO) or M(DABCO) (M = Mg, Mn, Fe, Co, Ni, Cu, Zn) MOFs using multiscale simulations that combined grand canonical Monte Carlo simulation with van der Waals density functional (vdW-DF) calculation. We find that, in the M(DABCO) series, Mg(DABCO) has the highest total CH4 adsorption capacities, with mtot= 231.39 mg/g at 298 K, for gravimetric uptake, and Vtot= 231.43 cc(STP)/cc, for volumetric uptake. The effects of temperature, pressure, and metal substitution on enhancing CH4 storage are evaluated, and we predict that the volumetric CH4 storage capacity on M(DABCO) could meet the DOE target at temperatures of ca. 238 K–268 K and pressures of 35–100 bar. The interactions between CH4 and M(DABCO) are dominated by the vdW interactions, as shown by the vdW-DF calculations. The Mg, Mn, Fe, Co, and Ni substitutions in M(DABCO) result in a stronger interaction and thus, a higher CH4 storage capacity, at higher pressures for Mg, Mn, Ni, and Co and at lower pressures for Fe. This work may provide guidance for the rational design of CH4 storage in M2(BDC)2(DABCO) MOFs.