bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Governance in China: A Comparative Analysis of the Prevention and Control of COVID-19
Authors: Lian Hongping
Published: May 2022

Pandemic prevention and control have become a top priority for local governance. This paper explores the governance logic and patterns in Hubei, Zhejiang, and Henan in China. Under the analytical framework (constituting decision-making and implementation capability, the effectiveness of information dissemination, infrastructural capability, the capability to coordinate horizontal departments and organize civil society, the capability to deliver services, and professional and innovative capability), governance behaviors embody different governance logics. Hubei embodies a traditional administrative-led bureaucratic system, Zhejiang realizes an inclusive public governance logic that relies on professionalism and innovation, and Henan exhibits a typical grassroots mobilization governance model based on mass participation. Speed, transparency, penetration, breadth, warmness, and intensity should be reflected in local officials’ behavior. Local governments are required to be given sufficient decision-making space, local administrative agencies and officials are required to have professional qualities and skills, and local governance should be understood under a new comparative path that explicitly incorporates local specificities.
Performance of (1) concrete-filled double-skin steel tube with and without core concrete, and (2) concrete-filled steel tubular axially loaded composite columns under close-in blast
Authors: Anas S.M. , Alam Mehtab , Umair Mohammad
Published: May 2022

Composite structural members such as concrete-filled double-skin steel tube (CFDSST) and concrete-filled double steel tubular (CFDST) columns are increasingly being utilized in modern structures owing to their capability to integrate the beneficial properties of constituent materials to carry heavy loads as compared to conventional reinforced concrete columns. Axial compression performance of such composite columns has been extensively investigated and available in the open literature. However, their response under impulsive loadings such as those induced by explosions is not very well studied because not many investigations have been conducted on these columns. Performance of composite compression members under short-duration/high-magnitude blast loading is of considerable interest under the prevailing environment of hi-tech wars, subversive activities, and accidental explosions. The recent devastating accidental Ammonium Nitrate explosion at Beirut port (Lebanon), and the ongoing invasion of Ukraine by Russia raise the concern of researchers and engineers for the safety of structural elements/components. In this study, a 3-D finite element model of axially loaded 2500 mm long CFDSST column of ultra-high-strength concrete (170 MPa) is developed in ABAQUS/Explicit-v.6.15 computer code equipped with Concrete Damage Plasticity (CDP) model, and investigation has been carried out for its blast performance under the 50kg-TNT explosive load at a standoff distance of 1.50 m in free-air. The effects of strain rate on the compressive strength of the concrete are considered as per fib Model Code 2010 (R2010) and UFC-3-340-02 (2008). The non-linear behavior of the steel is also taken into account. Damages in the form of (1) a - concrete crushing on the explosion side of the column and b - concrete cracking on the tension side and their spread over the column length, and (2) yielding of tubes are observed. Computational results are validated with the available experimental observations. To improve the column response, the analysis has been extended to investigate the blast performance of axially loaded CFDSST columns with and without core concrete having an inner steel tube of circular/square cross-section and their response have been compared with the equivalent single skin concrete-filled steel tubular circular/square columns of same axial load capacity.
Perceptions of traditional Chinese medicine doctors about using wearable devices and traditional Chinese medicine diagnostic instruments: A mixed-methodology study
Authors: Zhou Siyu , Li Kai , Ogihara Astushi , Wang Xiaohe
Published: May 2022

Objective

This study aimed to investigate the perceptions of traditional Chinese medicine doctors about wearable devices and diagnostic instruments and explore the factors that influence them.

Methods

Data on the perceptions of the traditional Chinese medicine doctors in Hangzhou, China, about wearable devices and diagnostic instruments were collected through face-to-face semi-structured interviews. The author coded the interview responses using grounded theory. A cross-sectional survey was conducted in four traditional Chinese medicine hospitals in Hangzhou, China. The responses of 385 traditional Chinese medicine doctors were considered valid. Descriptive statistics and binary logistic regression models were used for analysis.

Results

This study categorized the perceptions of traditional Chinese medicine about wearable devices and traditional Chinese medicine diagnostic instruments under convenience, reliability, suitable population, machine usage scenario, and the integration of traditional Chinese medicine and information communication technology. Convenience encompassed portability and the convenience of carrying instruments or wearing the devices and operating them and the human–device interface. Reliability encompassed the underlying principles, accuracy, durability, and reference to diagnosis. Suitability for people encompassed age distinction and disease differentiation. Machine usage scenarios included use in daily life, educational institutions, and primary medical institutions. The combination of traditional Chinese medicine and information communication technology encompassed the integration of traditional Chinese medicine and wearable functions and diagnostic interpretation. The perceptions of traditional Chinese medicine doctors were affected by age, title, type of hospital, and specialty.

Conclusions

The use of wearable devices and traditional Chinese medicine diagnostic instruments has gradually been accepted by traditional Chinese medicine doctors. Traditional Chinese medicine doctors need to improve their knowledge and skills for information communication technology integration, and their standardized training should incorporate information communication technology and digital health.
Predictors of positive outcomes following resistive inspiratory muscle training in non-ambulatory persons with advanced multiple sclerosis
Authors: Huang Min Hui , Doyle Lisa , Burnham Alexander , Fry Donna K. , Shea Keelin
Published: May 2022

Background

Inspiratory muscle training (IMT) using a threshold device improves inspiratory muscle strength. What factors influence the IMT outcome has not been examined.

Objective

To identify predictors of the positive outcome following IMT in persons with advanced multiple sclerosis (PwAMS).

Methods

Inclusion criteria were non-ambulatory PwAMS, Expanded Disability Status Scale (EDSS) ≥6.5, age >18 years, no acute medical conditions, current non-smokers, and ability to consent. Participants ( n = 38) performed daily inspiratory exercises using a resistive threshold device for 10 weeks. Baseline measurements included age, sex, body mass index, year post multiple sclerosis diagnosis, comorbidities, EDSS, Modified Fatigue Impact Scale-5, and oral Symbol Digit Modality Test. The percentage of completed prescribed exercise trials (Trials%) during the 10-week intervention was calculated. Age- and sex-adjusted predicted values of maximum inspiratory pressure (MIP%pred) and maximum expiratory pressure (MEP%pred) were obtained before and after the 10-week intervention. Backward multivariable regression analyses for the primary outcome (MIP%pred) were conducted.

Results

After controlling for the initial MIP%pred, perceived fatigue at the baseline and Trial% were significant and independent predictors of MIP%pred after IMT.

Conclusion

Less fatigue at the baseline and higher adherence to the prescribed exercise repetitions were positive predictors of the positive outcome following IMT in PwAMS.
Characterising genome architectures using genome decomposition analysis
Authors: Aunin Eerik , Berriman Matthew , Reid Adam James
Published: May 2022

Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression. We present a new tool called Genome Decomposition Analysis (GDA) that characterises genome architectures and acts as an accessible approach for discovering hidden features of a genome assembly. With the imminent deluge of high-quality genome assemblies from projects such as the Darwin Tree of Life and the Earth BioGenome Project, GDA has been designed to facilitate their exploration and the discovery of novel genome biology. We highlight the effectiveness of our approach in characterising the genome architectures of single-celled eukaryotic parasites from the phylumApicomplexaand show that it scales well to large genomes.
Impact of self-coiling catheters for continuous popliteal sciatic block on postoperative pain level and dislocation rate: a randomized controlled trial
Authors: Nickl Rosa , Vicent Oliver , Müller Thomas , Osmers Anne , Schubert Konrad , Koch Thea , Richter Torsten
Published: May 2022

Background

Dislocation of catheters within the tissue is a challenge in continuous regional anesthesia. A novel self-coiling catheter design is available and has demonstrated a lower dislocation rate in a cadaver model. The dislocation rate and effect on postoperative pain of these catheters in vivo has yet to be determined and were the subjects of this investigation.

Methods

After ethics committee approval 140 patients undergoing elective distal lower limb surgery were enrolled in this prospective randomized controlled trial. Preoperatively, patients were randomly assigned and received either the conventional (n = 70) or self-coiling catheter (n = 70) for ultrasound-guided popliteal sciatic nerve block in short axis view and by the in-plane approach from lateral to medial. The primary outcome was pain intensity after surgery and on the following three postoperative days. Secondary outcomes investigated were dislocation rate in situ determined by sonography, catheter movement visible from outside, opioid consumption as well as leakage at the puncture site.

Results

All catheters were successfully inserted. The study population of self-coiling catheters had significantly lower mean numeric rating scale values than the reference cohort on the first (p = 0.01) and second postoperative days (p < 0.01). Sonographic evaluation demonstrated, 42 standard catheters (60%) and 10 self-coiling catheters (14.3%) were dislocated in situ within the first three postoperative days. The externally visible movement of the catheters at insertion site did not differ significantly between groups through the third postoperative day. The opioid consumption was significantly lower in the self-coiling catheter group on the day of surgery and on the second and third postoperative days (p = 0.04,p = 0.03 andp = 0.04, respectively).

Conclusion

The self-coiling catheter offers a better postoperative pain control and a lower dislocation rate within the tissue when blocking the popliteal sciatic nerve compared to a conventional catheter. Further trials in large patient cohorts are warranted to investigate the potential beneficial effects of self-coiling catheters for other localisations and other application techniques.

Trial registration

The trial was registered at German Clinical Trials Register (DRKS) on 08/04/2020 (DRKS00020938, retrospectively registered).
Reproducibility and feasibility of optic nerve diffusion MRI techniques: single-shot echo-planar imaging (EPI), readout-segmented EPI, and reduced field-of-view diffusion-weighted imaging
Authors: Zhou Fanglu , Li Qing , Zhang Xiaohui , Ma Hongli , Zhang Ge , Du Silin , Zhang Lijun , Benkert Thomas , Zhang Zhiwei
Published: May 2022

Background

Diffusion-weighted imaging (DWI) is an essential technique for optic nerve diseases. However, the image quality of optic nerve DWI is decreased by the distortions and artifacts associated with conventional techniques. In order to establish this method as a critical tool in optic nerve diseases, reproducibility and feasibility of new technical and conventional approaches of DWI need to be systematically investigated.

Methods

DWIs were acquired using ss-EPI, readout-segmented EPI (rs-EPI) DWI, and reduced field-of-view (rFOV) DWI. 26 volunteers (mean age 31.2 years) underwent repeated MRI examinations in order to assess scan–rescan reproducibility and accuracy. The apparent diffusion coefficient (ADC) values (three ROIs were measured on each side) were determined to evaluate the reproducibility of each sequence and the differences between the three techniques. To quantify the geometric distortion artifacts, the length of optic nerve and the maximum angle of optic nerve were defined and compared to T2-weighted imaging. In addition, two readers evaluated four different aspects of image quality on 5-point Likert scales.

Results

rs-EPI DWI (ICCs: 0.916, 0.797 and 0.781) and rFOV DWI (ICCs: 0.850, 0.595 and 0.750) showed higher reproducibility (ICCs: ROI1, ROI2 and ROI3) of mean ADC value in all three ROIs than ss-EPI DWI (ICCs: 0.810, 0.442 and 0.379). The quantitative analysis of geometric distortion yielded a higher agreement of both rs-EPI DWI and rFOV DWI with T2-weighted imaging than ss-EPI. rs-EPI DWI (2.38 ± 0.90) and rFOV DWI (2.46 ± 0.58) were superior to ss-EPI DWI (1.58 ± 0.64) with respect to overall image quality and other aspects of image quality, each with P < 0.05. The mean ADC values of rFOV DWI were significantly lower than those of rs-EPI DWI and ss-EPI DWI in all three ROIs (P < 0.001).

Conclusions

Both rs-EPI DWI and rFOV-EPI DWI are suitable techniques for the assessment of diffusion restriction and provide significantly improved image quality compared with ss-EPI DWI. For methods using the same acquisition time, rFOV DWI is superior to ss-EPI DWI, while rs-EPI showed an overall superiority, although this technique took 47% longer to perform.
Practical utility of liver segmentation methods in clinical surgeries and interventions
Authors: Ansari Mohammed Yusuf , Abdalla Alhusain , Ansari Mohammed Yaqoob , Ansari Mohammed Ishaq , Malluhi Byanne , Mohanty Snigdha , Mishra Subhashree , Singh Sudhansu Sekhar , Abinahed Julien , Al-Ansari Abdulla , Balakrishnan Shidin , Dakua Sarada Prasad
Published: May 2022

Clinical imaging (e.g., magnetic resonance imaging and computed tomography) is a crucial adjunct for clinicians, aiding in the diagnosis of diseases and planning of appropriate interventions. This is especially true in malignant conditions such as hepatocellular carcinoma (HCC), where image segmentation (such as accurate delineation of liver and tumor) is the preliminary step taken by the clinicians to optimize diagnosis, staging, and treatment planning and intervention (e.g., transplantation, surgical resection, radiotherapy, PVE, embolization, etc). Thus, segmentation methods could potentially impact the diagnosis and treatment outcomes. This paper comprehensively reviews the literature (during the year 2012–2021) for relevant segmentation methods and proposes a broad categorization based on their clinical utility (i.e., surgical and radiological interventions) in HCC. The categorization is based on the parameters such as precision, accuracy, and automation.
Correlation between red blood cell distribution width, neutrophil to lymphocyte ratio, and neutrophil to platelet ratio with 3-month prognosis of patients with intracerebral hemorrhage: a retrospective study
Authors: Shaafi Sheida , Bonakdari Ehsan , Sadeghpour Yalda , Nejadghaderi Seyed Aria
Published: May 2022

Background

Red cell distribution width (RDW) is a parameter that indsicates the heterogeneity of red blood cell size and could be a prognostic factor in some diseases. Also, intracerebral hemorrhage (ICH) is considered a vascular event with a high mortality rate. We aimed to examine the role of RDW, neutrophil to lymphocyte ratio (NLR), and neutrophil to platelet ratio (NPR) in predicting the prognosis of patients with ICH.

Methods

This is a retrospective cohort study conducted on 140 patients with ICH admitted to the neurology ward and intensive care unit (ICU) in Imam Reza Hospital, Tabriz, Iran. Demographic data, National Institutes of Health Stroke Scale (NIHSS), and complete blood count test parameters were evaluated within 24 h after hospitalization. These variables were collected and re-evaluated three months later.

Results

The mean age of the study population was 61.14 (± 16) years and 51% were male. The mean NLR (p = 0.05), neutrophil count (p=0.04), platelet count (p = 0.05), and NIHSS (p<0.01)  had a significant difference between the deceased patients and those who partially recovered after three months. The ROC curve showed that NIHSS (area under curve (AUC): 0.902), followed by NPR (AUC: 0.682) variables had the highest AUC.

Conclusion

RDW could be a relevant prognostic factor and predictor in determining 3-months survival in ICH. Nevertheless, further large-scale prospective cohorts might be needed to evaluate the associations.
Small + Safe + Well: lessons learned from a Total Worker Health® randomized intervention to promote organizational change in small business
Authors: Schwatka Natalie V. , Dally Miranda , Shore Erin , Tenney Liliana , Brown Carol E. , Scott Joshua G. , Dexter Lynn , Newman Lee S.
Published: May 2022

Background

Leadership commitment to worker safety and health is one of the most important factors when organizations develop and implement a Total Worker Health® approach. We aimed to assess the effectiveness of a Total Worker Health (“TWH”) leadership development program that targeted owners and other senior-level leadership positions on changing organizational and worker outcomes from baseline to one-year later.

Methods

The Small + Safe + Well study included small businesses from a variety of industries in the state of Colorado, USA that were participating in Health Links™. We designed a randomized waitlisted control comparison design (RCT) to evaluate the added benefit of a TWH leadership development program. An employer assessment tool was used to assess TWH policies and programs, and an employee health and safety survey was used to assess safety leadership and health leadership practices, safety climate and health climate, safety behaviors and health behaviors, and well-being. We used a linear mixed model framework with random effects for business and employee to assess the impact of intervention on the outcomes of interest.

Results

Thirty-six businesses (37% retention) and 250 employees (9% retention) met the RCT study inclusion criteria and were included in the analysis. Businesses improved their TWH policies and programs score from baseline to one-year later, regardless of leadership intervention group assignment. Neither intervention group demonstrated improvements in employee-reported outcomes.

Conclusions

This study sought to address a gap in the literature regarding small business senior leadership development for TWH. Our study demonstrates many of the challenges of conducting studies focused on organizational change in workplaces, specifically in small businesses. When designing TWH intervention studies, researchers should consider how to best engage small business leaders in interventions and implementations early on, as well as methods that are well matched to measuring primary and secondary outcomes longitudinally. Future research is needed to test the feasibility and sustainability of TWH interventions in small business.

Trial registration

The trial was retrospectively registered with ClinicalTrials.gov (ID U19OH011227).
Perceived stigma, substance use and self-medication in night-shift healthcare workers: a qualitative study
Authors: Cousin Lorraine , Roucoux Guillaume , Petit Anne Sophie , Baumann-Coblentz Laurence , Torrente Olivia Rousset , Cannafarina Adriano , Chassany Olivier , Duracinsky Martin , Carrieri Patrizia
Published: May 2022

Background

Many risk factors related to altered circadian rhythms impact the health of night-shift hospital workers (NSHW), resulting in mental and somatic disorders. Easy access to psychoactive substances (PS) may facilitate addictive behaviors in NSHW. They are also exposed to a stressful work environment, which may further affect sleep quality. This study aimed to explore the link between sleep deprivation, work-related psychosocial stress and psychoactive substance use as a self-medication response in NSHW.

Methods

Qualitative study to verify the plausibility of the self-medication theory applied to addictive behaviors. Semi-structured interviews (N = 18 NSHW) and thematic analysis, following consolidated criteria for reporting qualitative research recommendations.

Results

Stigma against NSHW was a primary element of a stressful work environment. The stressful and stigmatizing environment, together with night-shift work, further affected NSHW sleep and their mental and physical health. The use of PS appeared to be for self-medication, encouraged by social and professional environments, source(s) of stress, discrimination, and isolation. The work environment, through aggravated sleep disorders, led NSHW to use non-prescribed sleeping pills. Alcohol after work and smoking were used as a social break but also as a means to reduce stress.

Conclusion

Anti-stigma interventions in the healthcare setting and screening of mental/somatic disorders in NSHW can help reduce harmful self-medication behaviors and improve hospital care in the COVID-19 era.
Development of a multidimensional housing and environmental quality index (HEQI): application to the American Housing Survey
Authors: Chu MyDzung T. , Fenelon Andrew , Rodriguez Judith , Zota Ami R. , Adamkiewicz Gary
Published: May 2022

Background

Substandard housing conditions and hazardous indoor environmental exposures contribute to significant morbidity and mortality worldwide. Housing indices that capture the multiple dimensions of healthy housing are important for tracking conditions and identifying vulnerable households. However, most indices focus on physical deficiencies and repair costs and omit indoor environmental exposures, as few national data sources routinely collect this information.

Methods

We developed a multidimensional Housing and Environmental Quality Index (HEQI) based on the World Health Organization’s Housing and Health Guidelines and applied it to the 2019 American Housing Survey (AHS). The HEQI consisted of ten domains associated with poor health: household fuel combustion, dampness and mold, pests and allergens, lead paint risk, high indoor temperatures, low indoor temperatures, household crowding, injury hazards, inadequate water and sanitation, and ventilation. We evaluated the validity and performance of the HEQI against three housing characteristics (i.e., year built, monthly rent costs, unit satisfaction rating) and two established indices (i.e., Adequacy Index, Poor Quality Index).

Results

Approximately 79% (92 million) of U.S. households reported at least one HEQI domain associated with poor health (mean per household: 1.3; range: 0,8). Prevalent domains included household fuel combustion (61.4%), dampness and mold (15.9%), inadequate water and sanitation (14.3%), and injury hazards (11.9%). Pests and allergens, low indoor temperatures, and injury hazards were consistently associated with older homes, lower rent costs, and lower unit satisfaction. Compared to established housing indices, the HEQI captured four new environmental domains which enabled the identification of 57.7 million (63%) more households with environmental risk factors like mold, cockroaches, crowding, household fuel combustion, and higher building leakage.

Conclusions

Indoor environmental exposures are prevalent in U.S. households and not well-captured by existing housing indices. The HEQI is a multidimensional tool that can be used to monitor indoor environmental exposures and housing quality trends in the U.S. Some domains, including radon, pesticides, asbestos, noise, and housing accessibility could not be assessed due to the lack of available data in the AHS. The mounting evidence linking residential environmental exposures with adverse health outcomes underscore the need for this data in the AHS and other national surveys.
Clinical analysis and artificial intelligence survival prediction of serous ovarian cancer based on preoperative circulating leukocytes
Authors: Feng Ying , Wang Zhixiang , Cui Ran , Xiao Meizhu , Gao Huiqiao , Bai Huimin , Delvoux Bert , Zhang Zhen , Dekker Andre , Romano Andrea , Wang Shuzhen , Traverso Alberto , Liu Chongdong , Zhang Zhenyu
Published: May 2022

Circulating leukocytes are an important part of the immune system. The aim of this work is to explore the role of preoperative circulating leukocytes in serous ovarian carcinoma and investigate whether they can be used to predict survival prognosis. Routine blood test results and clinical information of patients with serous ovarian carcinoma were retrospectively collected. And to predict survival according to the blood routine test result the decision tree method was applied to build a machine learning model.

The results showed that the number of preoperative white blood cells (p = 0.022), monocytes (p < 0.001), lymphocytes (p < 0.001), neutrophils (p < 0.001), and eosinophils (p < 0.001) and the monocyte to lymphocyte (MO/LY) ratio in the serous ovarian cancer group were significantly different from those in the control group. These factors also showed a correlation with other clinicopathological characteristics. The MO/LY was the root node of the decision tree, and the predictive AUC for survival was 0.69. The features involved in the decision tree were the MO/LY, differentiation status, CA125 level, neutrophils (NE,) ascites cytology, LY% and age.

In conclusion, the number and percentage of preoperative leukocytes in patients with ovarian cancer is changed significantly compared to those in the normal control group, as well as the MO/LY. A decision tree was built to predict the survival of patients with serous ovarian cancer based on the CA125 level, white blood cell (WBC) count, presence of lymph node metastasis (LNM), MO count, the MO/LY ratio, differentiation status, stage, LY%, ascites cytology, and age.
Venous return and mean systemic filling pressure: physiology and clinical applications
Authors: Persichini Romain , Lai Christopher , Teboul Jean-Louis , Adda Imane , Guérin Laurent , Monnet Xavier
Published: May 2022

Venous return is the flow of blood from the systemic venous network towards the right heart. At steady state, venous return equals cardiac output, as the venous and arterial systems operate in series. However, unlike the arterial one, the venous network is a capacitive system with a high compliance. It includes a part of unstressed blood, which is a reservoir that can be recruited via sympathetic endogenous or exogenous stimulation. Guyton’s model describes the three determinants of venous return: the mean systemic filling pressure, the right atrial pressure and the resistance to venous return. Recently, new methods have been developed to explore such determinants at the bedside. In this narrative review, after a reminder about Guyton’s model and current methods used to investigate it, we emphasize how Guyton’s physiology helps understand the effects on cardiac output of common treatments used in critically ill patients.
Efficacy and safety of Elian Granules in treating chronic atrophic gastritis: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial
Authors: Gu Zhijian , Jia Qingling , Cong Jun , Cen Rong , Chen Yongqi , Wu Chenheng , Gong Biao , Tang Xudong , Ling Jianghong
Published: May 2022

Background

Multifocal atrophic gastritis and intestinal metaplasia are considered to be important links in the gastric precancerous cascade. However, there are no specific drugs for these conditions. Although many studies have shown that traditional Chinese medicine is effective with no serious side effects, these studies have not been scientifically rigorous trials. Our aim is to design a high-quality trial for a Chinese patent medicine, Elian Granules, to investigate its efficacy and safety in treating patients with chronic atrophic gastritis with or without intestinal metaplasia.

Methods

This is a phase II, randomized, double-blind, placebo-controlled, multicenter clinical trial. A total of 240 participants will be assigned to a treatment or placebo control group in a 1:1 ratio. The experimental drug or placebo will be taken with boiling water, two small bags (24.2 g) each time, twice a day, half an hour after a meal, for 24 weeks. The primary outcome is the observation of histological changes in the gastric mucosa of patients with atrophic gastritis with or without intestinal metaplasia after 6 months based on the OLGA/OLGIM staging systems. The secondary outcomes include the assessment of dyspepsia and quality of life based on the dyspepsia symptom score and the quality-of-life scale.

Discussion

This study is designed to evaluate the efficacy and safety of Elian Granules in a randomized, double-blind, placebo-controlled, multicenter manner. This trial may not only provide evidence for a phase III clinical trial, but also an alternative option for the treatment of chronic atrophic gastritis (CAG).

Trial registration

Registry Platform For Evidence-Based Traditional Chinese Medicine ChiMCTR2000003929. Registered on 13 September 2020
Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate
Authors: Tao Chenqi , Makrides Neoklis , Chuang Jen-Zen , Wu Yihua , Brooks Steven E. , Esko Jeffrey D. , Sung Ching-Hwa , Zhang Xin
Published: May 2022

Glycosaminoglycans are ubiquitously expressed polysaccharides that are attached to proteoglycans. Here, we showed that ablation of the heparan sulfate (HS) polymerase Ext1 in retinal progenitor cells did not affect initial progression of retinal angiogenesis, but it disrupted the pruning of blood vessels and establishment of arterioles and venules. In the absence of retinal HS, blood vessels were also vulnerable to high oxygen tension in early postnatal stages, which could be rescued by exogenous vascular endothelial growth factor (VEGF), consistent with the role of retinal HS in the fine-tuning of VEGF signaling. Furthermore, we observed that the retinal inner limiting membrane (ILM) was disrupted by deletion of Ext1 in a timing-specific manner, suggesting that retinal HS is required for the assembly but not the maintenance of the basement membrane. Lastly, we showed that further deletion of C4st1, a chondroitin sulfate (CS) sulfation enzyme, did not affect the assembly of the ILM but, when combined with Ext1 deletion, it aggravated the retinal permeability by disrupting the retinal glycocalyx. These results demonstrate an important role of CS and HS in establishing the barrier function of the extracellular matrix.
Rural-Urban Differences in Breast Cancer Surgical Delays in Medicare Beneficiaries
Authors: Zipkin Ronnie J. , Schaefer Andrew , Wang Changzhen , Loehrer Andrew P. , Kapadia Nirav S. , Brooks Gabriel A. , Onega Tracy , Wang Fahui , O’Malley Alistair J. , Moen Erika L.
Published: May 2022

Background

Delays between breast cancer diagnosis and surgery are associated with worsened survival. Delays are more common in urban-residing patients, although factors specific to surgical delays among rural and urban patients are not well understood.

Methods

We used a 100% sample of fee-for-service Medicare claims during 2007–2014 to identify 238,491 women diagnosed with early-stage breast cancer undergoing initial surgery and assessed whether they experienced biopsy-to-surgery intervals > 90 days. We employed multilevel regression to identify associations between delays and patient, regional, and surgeon characteristics, both in combined analyses and stratified by rurality of patient residence.

Results

Delays were more prevalent among urban patients (2.5%) than rural patients (1.9%). Rural patients with medium- or high-volume surgeons had lower odds of delay than patients with low-volume surgeons (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.58–0.88; OR = 0.74, 95% CI = 0.61–0.90). Rural patients whose surgeon operated at ≥ 3 hospitals were more likely to experience delays (OR = 1.29, 95% CI = 1.01–1.64, Ref: 1 hospital). Patient driving times ≥ 1 h were associated with delays among urban patients only. Age, black race, Hispanic ethnicity, multimorbidity, and academic/specialty hospital status were associated with delays.

Conclusions

Sociodemographic, geographic, surgeon, and facility factors have distinct associations with > 90-day delays to initial breast cancer surgery. Interventions to improve timeliness of breast cancer surgery may have disparate impacts on vulnerable populations by rural-urban status.
Do State-Sponsored Retirement Plans Boost Retirement Saving?
Authors: Chalmers John , Mitchell Olivia S. , Reuter Jonathan , Zhong Mingli
Published: May 2022

Oregon recently launched an automatic-enrollment retirement savings program for private sector workers lacking access to other workplace retirement plans. We analyze participation choices, account balances, and inflow/outflow data using administrative records between August 2018 and April 2020. Within the small to mid-sized firms served by OregonSaves, estimated average after-tax earnings are low ($2,365 per month) and turnover rates are high (38.2 percent per year). Younger employees and employees in larger firms are less likely to opt out, but participation rates fall over time. Overall, we conclude that OregonSaves has meaningfully increased employee savings by reducing search costs.
Youth Hiring and Labor Market Tightness
Authors: Forsythe Eliza C.
Published: May 2022

It is well-known that recessions can lead to long-term scarring for young workers. I show that employers hire fewer young workers when there are few job openings per unemployed job seeker, while hiring rates for workers with more than 10 years of potential experience are much less cyclically volatile. During the COVID-19 pandemic, youth employment rates rebounded particularly quickly compared with other groups and historic patterns. I show this is consistent with the historic relationship between tightness and youth hiring rates, suggesting youth scarring from the COVID-19 pandemic may be less severe compared with previous recessions.
Migration on the Rise, a Paradigm in Decline: The Last Half-Century of Global Mobility
Authors: A. Clemens Michael
Published: May 2022

The past several decades have witnessed a rebirth of global labor mobility. Workers are moving between countries at rates not seen since before World War I. During the same period, economists' study of international migration has been framed by a particular textbook model of location choice. This paper reviews the evidence on the economic causes and effects of global migration during the past half century. That evidence falsifies most of the core predictions of the old model. The economics of migration will regain vitality and relevance by discarding and replacing its outworn paradigm.
Women's Employment and Empowerment: Descriptive Evidence
Authors: McKelway Madeline
Published: May 2022

It is widely believed that female employment and empowerment are intimately related. This paper presents relationships between women's employment and various measures of their empowerment, using data from rural India. The measures capture several dimensions of empowerment, including control in economic decision-making, psychosocial aspects of empowerment, and women's own internalization of a lesser status. A number of these measures correlate positively with women's employment, supporting the notion that female employment and empowerment are closely linked.
Ranking and Selection from Pairwise Comparisons: Empirical Bayes Methods for Citation Analysis
Authors: Gu Jiaying , Koenker Roger
Published: May 2022

In this paper, Stigler's (1994) model of citation flows among journals adapted to the pairwise comparison model of Bradley and Terry (1952) is employed to do ranking and selection of journal influence based on nonparametric empirical Bayes methods. Comparisons with several other ranking are also made.
Scapegoating during Crises
Authors: Bursztyn Leonardo , Egorov Georgy , Haaland Ingar , Rao Aakaash , Roth Christopher
Published: May 2022

Economic crises are often accompanied by waves of antiminority behavior. We build on the framework developed in Bursztyn et al. (2022) to propose that crises, in addition to shifting people's attitudes toward minorities, can provide intolerant people with a plausible rationale for expressing their preexisting prejudice. The availability of such a rationale thus increases antiminority behavior by reducing the associated social sanctions. In an experiment examining how economic crises affect social inference about the motives underlying xenophobic behavior, we find that crises lead respondents to ascribe antiminority behavior to economic concerns rather than to innate xenophobia.
Eliciting People’s First-Order Concerns: Text Analysis of Open-Ended Survey Questions
Authors: Ferrario Beatrice , Stantcheva Stefanie
Published: May 2022

We illustrate the design and use of open-ended survey questions to elicit people's first-order concerns on policies. Closed-ended questions are the backbone of surveys but may prime respondents to select some answers and may omit relevant options. Open-ended questions that do not constrain respondents with specific answer choices are a valuable tool for eliciting first-order thinking. We discuss three text analysis methods to analyze open-ended questions' answers and apply them to surveys on income and estate taxation. People's key concerns relate mostly to distribution issues, fairness, and trust in government rather than to efficiency, and they exhibit large partisan gaps.
Global Life Insurers during a Low Interest Rate Environment
Authors: Koijen Ralph S. J. , Yogo Motohiro
Published: May 2022

Life insurers' business model has changed with the growth of insurance products with minimum return guarantees that are exposed to market and interest risks. The interest risk exposure of US and European insurers increased in the low-rate environments after the global financial crisis and the European sovereign debt crisis, respectively. The relative fragility of life insurers is highly persistent across the global financial crisis, the European sovereign debt crisis, and the COVID-19 crisis. European insurers with a higher share of liabilities with minimum return guarantees in 2016 had lower stock returns during the COVID-19 crisis.
Masks and Trolleys in San Francisco during the 1918 Influenza Epidemic
Authors: Velde François R.
Published: May 2022

I analyze daily data on deaths and on mobility (ridership of electric railways) in the city of San Francisco in 1918-1919, using a model that combines a standard epidemiological component, agents who choose economic activity taking infection risk into account, and exogenous restrictions on activity (lockdowns). Masks were imposed twice but restrictions on activity were imposed only once. I use this to estimate the impact of masks on transmission. The behavioral feedback is important in capturing the dynamics of the epidemic, and masks appear to have been effective.
Persistent Monetary Policy in a Model with Labor Market Frictions
Authors: Goncharenko Roman , Lukmanova Elizaveta
Published: May 2022

In a basic New Keynesian DSGE model with involuntary unemployment and inflation target shocks, we study the role of labor markets in the transmission of persistent monetary policy shocks that increase households' inflation expectations. The model predicts that labor market conditions can play an important role in the transmission channel of the persistent inflation target shock: quantitatively realistic labor market frictions increase the expansionary effect of inflation target shock on output by around a half compared to that under the model without labor market frictions. Using VAR analysis, we further provide empirical evidence consistent with the predictions of our theoretical model.
Do Bonuses Offset the Allocative Effects of Downward Rigid Base Wages?
Authors: Funk Anne Kathrin , Kaufmann Daniel
Published: May 2022

We measure the labor market outcomes of employees with downward rigid base wages after an unexpected deflationary shock in Switzerland using a firm survey matched with Social Security register data. The employees that additionally receive downward flexible compensation, such as bonuses, are less likely to lose their job after a deflationary shock than those only receiving a base wage. Only a modest share of employees receives downward flexible compensation, however. Therefore, these compensation schemes do not offset the overall allocative effects of downward rigid base wages.
Does (All) Police Violence Cause De-policing? Evidence from George Floyd and Police Shootings in Minneapolis
Authors: Mikdash Maya , Zaiour Reem
Published: May 2022

We test for a “Ferguson Effect” by studying how police effort responds to different incidents of police violence. We do so using two settings in Minneapolis: (1) George Floyd's murder, and (2) police-involved shootings. We find that following George Floyd's death, arrests and police-initiated calls decreased by 62 and 69 percent, respectively. By comparison, arrests and police-initiated calls decreased by 3 and 1.5 percent following police-involved shootings. We conclude that incidents of police violence generate “de-policing,” and the effect is much larger following highly publicized incidents.
Discrimination, Segregation, Integration, and Expropriation
Authors: Williams Geoffrey Fain
Published: May 2022

I look at simple models of segregation and integration in a regional economy using a standard Cobb-Douglas production function and show that White capital does better in integration and White labor does better in segregation. I suggest that White capital and labor can resolve this difference in interests by integrating Black labor and expropriating some of the wages of these Black workers. I then introduce the third production factor of human capital, where the ethnic groups have different access to resources for human capital development. I show that this can lead to outcomes very similar to the expropriation model. Both the expropriation and limited human capital models appear to match available data for some US labor markets in the 1865-1965 period.
Sundown Towns and Racial Exclusion: The Southern White Diaspora and the “Great Retreat”
Authors: Bazzi Samuel , Ferrara Andreas , Fiszbein Martin , Pearson Thomas , A. Testa Patrick
Published: May 2022

This paper studies the rise of sundown towns--places where Blacks and other minorities were excluded after dark--outside the South after 1890. We provide a new dataset on the timing of sundown town establishment using full count census records. Using a shift-share instrumental variables approach, we show that the presence of Southern Whites is causally related to the appearance of sundown towns, with lynchings and the establishment of KKK chapters as plausible mechanisms for racial exclusion.
On the Impact of Federal Housing Policies on Racial Inequality
Authors: Ali Omer
Published: May 2022

Using data on the value of Federal Housing Administration (FHA) mortgage insurance between 1935 and 1939, I estimate the effect of the agency's program on racial disparities in home ownership and home values. The distance between an FHA office and counties within its jurisdiction is used as an instrument. I find that insurance activity had a negligible effect on the racial gap in home ownership and a sizable effect on the gap in home values. Results suggest that while African American households continued to acquire homes, they may have chosen lower-priced properties, as they lacked the same access to credit as White buyers.
The Racial Wealth Gap and the Role of Firm Ownership
Authors: Lipton Avi
Published: May 2022

This paper develops an overlapping generations model that isolates the impact of the US racial wealth gap in 1962 on the long-run dynamics of wealth. The model predicts that one component of the initial gap, firm ownership, coupled with the intergenerational transfer of that ownership results in a permanent wealth gap independent of other dimensions of inequality. This implies that even if all discrimination against Black Americans had ceased upon the end of Jim Crow, the wealth gap would have persisted without a reparations policy addressing the fact that the initial firm ownership gap arose in the first place.
How Do Federal Policy Shocks to State Spending Impact Returns to Primary and Secondary Education?
Authors: Williams Miesha Jamell
Published: May 2022

Using NIPA and IPEDS data from 2000 to 2017, this research employs a panel event-study VAR to determine the recursive impact of federal education policy on college enrollment and state spending on education. Specifically, this project focuses on race and gender to analyze the Elementary and Secondary Education Act, and Common Core State Standards as random shocks to federal spending. Do federal policy or state standards help educational disparities? Findings indicate decentralized policies or standards must be centrally aligned to be effective in the US. Improvements must be made for all demographic groups.
COVID-19 and Its Impact on Minority-Owned Banks
Authors: Contreras Salvador , Ghosh Amit
Published: May 2022

Employing a difference-in-differences framework, we examine the effect of COVID-19 on various performance metrics of minority-owned banks relative to peer banks. We find little evidence of worsening performance of minority-owned banks, except for Asian-owned banks. In some instances, minority banks show improved performance. We find a decline in nonperforming single-family residential loans for Hispanic-owned banks. Moreover, minority banks have disbursed more Paycheck Protection Program (PPP) loans than their matched non-minority counterparts. Their resilient performance indicates that minority banks are well positioned to aid in the ongoing economic recovery.