bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunosuppressive therapy of patients with pemphigus with ineffectiveness of systemic corticosteroids
Authors: Chikin Vadim V. , Karamova Arfenya E.
Published: November 2024

Therapy of patients with pemphigus vulgaris with systemic corticosteroids may not be effective enough or lead to the development of severe adverse events that make it necessary to reduce the dose of corticosteroid. In such cases, it is possible to use the immunosuppressants. The literature review analyzes case reports and the results of studies that evaluated the effectiveness and safety of drugs used for immunosuppressive therapy of patients with pemphigus vulgaris. The drugs doses, the studies design, and criteria for evaluating the effectiveness of therapy in patients with pemphigus are considered. As a result of the analysis, it was shown that case reports and non-compatarive studies demonstrate the effectiveness and steroid-sparing effect of azathioprine, dapsone, methotrexate, mycophenolate mofetil, cyclosporine and cyclophosphamide in the treatment of patients with pemphigus vulgaris. Nevertheless, comparative studies show an increase in the effectiveness of therapy in patients with pemphigus and a faster achievement of therapeutic effect when prescribing cyclophosphamide, but not azathioprine, dapsone, methotrexate, mycophenolate mofetil or cyclosporine. However, the toxicity of cyclophosphamide limits its use in pemphigus. Thus, adjuvant drugs can be used in the treatment of patients with pemphigus in situations where it is not possible to reduce the dose of a systemic corticosteroid, especially in cases of severe adverse events of corticosteroid therapy.
Islamic Students’ Achievement Emotions in Attending Algebra Class: Differences of Gender, Algebraic Content, Teaching Method, and Teacher Knowledge
Authors: Suparman Suparman , Juandi Dadang , Turmudi Turmudi
Published: November 2024

Indonesian Islamic students’ achievement emotions in conducting mathematics activities have relatively not been stable because their positive emotions decrease and their negative emotions increase (Suparman et al., 2021). The differences in students' achievement emotions in algebra class are predictively affected by natural and manipulated academic factors. This study describes Islamic students' achievement emotions in algebra class considering the differences in gender, teaching method, algebraic content, and teachers' technological, pedagogical, and content knowledge (TPACK). A survey study on three mathematics teachers and 90 tenth-, eleventh-, or twelfth-grade students at a public Islamic school in West Java, Indonesia was applied. A few questionnaires, such as TPACK and achievement emotions in mathematics were used to measure students' achievement emotions and teachers' TPACK. Particularly, the questionnaire of achievement emotions in mathematics was valid (r = 0.64) and reliable (α = 0.90). Additionally, the questionnaire of teacher’s TPACK was also valid (r = 0.69) and reliable (α = 0.84). Independent samples-t test and one-way MANOVA test were applied to analyze the data. Results revealed that male students' shame was significantly lower than female students in algebra class. Additionally, there were significant differences in teaching methods and teachers' TPACK in students' enjoyment, anger, hopelessness, and boredom. Moreover, there were significant differences in algebraic contents in students' positive and negative emotions. Consequently, mathematics teachers in Islamic school institutions must pay attention to the differences in gender, teaching method, teachers' TPACK, and algebraic contents related to students' achievement emotions in doing mathematics activities.
Água como direito humano e fundamental para a vida: estudo da qualidade da água consumida por residentes da região da Lagoa de Cima
Authors: Chrispim Zélia Maria , Portella Tatiana Salema Marques , De Souza Frank Pavan , Das Chagas Thaíss do Rosario , Santos Kariny Alves de Sousa
Published: November 2024

A água é um recurso mineral de fundamental importância para a vida de todas as espécies. O conhecimento de sua qualidade é de relevância, pois, atividades antrópicas têm degradado significativamente os recursos hídricos nos últimos tempos.  Tendo em vista que a água é um direito fundamental, garantido pela Constituição Federal e também estabelecido pela ONU com indispensável para a sobrevivência dos seres vivos, esta pesquisa teve como objetivo verificar os parâmetros da potabilidade da água consumida por moradores do núcleo urbano de São Benedito, localizado na Unidade de Conservação Área de Proteção Ambiental (APA) da Lagoa de Cima, no Município de Campos dos Goytacazes - RJ. Quanto à metodologia foram realizadas as seguintes etapas: coleta de dados bibliográficos e documentais, tais como: portaria, teses, artigos, arquivos de “shapefiles” pré-existentes da Lagoa de Cima e do município de Campos dos Goytacazes; revisão biblográfica; coletas de amostras de águas de poços rasos para análises físico-químicas e bacteriológicas, geração de mapa com as amostras de água espacializados e elaboração de tabelas. Conforme os resultados obtidos com as análises microbiológicas, verificou-se a presença de coliformes totais e de coliformes termotolerantes em algumas amostras. Dentre os parâmetros físico-químicos avaliados, o pH, o Fe e o Mn apresentaram concentrações acima dos valores máximos permitidos (VMP) ao consumo humano. Em vista dos argumentos apresentados, a presente pesquisa alerta para a condição da qualidade de água consumida pela população da região da Lagoa de Cima.  Conforme visto, os dados analisados apontam para um cenário desfavorável em termos de riscos à saúde pública. Deste modo, é necessário que os gestores públicos façam um atendimento para população local em relação à qualidade da água e ao saneamento urbano.
Obesidade no Brasil: desafios sociais, econômicos e de saúde pública
Authors: Valentim Cesar Guilherme Queiroz , Rebelo João Felipe Dickson , Vasconcelos Lucia Helena Ferreira , Oliveira Danielle Furtado de , Duarte Nathalia Lopez
Published: November 2024

Objetivo: Analisar o impacto dos fatores socioeconômicos na prevalência da obesidade na população brasileira. Revisão bibliográfica: A obesidade, definida por um Índice de Massa Corporal (IMC) igual ou superior a 30,0 kg/m², é uma doença crônica que afeta milhões de pessoas globalmente. No Brasil, a prevalência de obesidade está fortemente ligada a fatores socioeconômicos. Indivíduos de baixa renda, com menor escolaridade e mulheres negras são desproporcionalmente afetados. O ambiente obesogênico, caracterizado pela falta de acesso a alimentos saudáveis e à infraestrutura adequada para a prática de atividades físicas, contribui para o aumento dos índices de obesidade. Adicionalmente, o consumo de alimentos ultraprocessados e as condições de trabalho precárias intensificam essa situação, especialmente em regiões com menor desenvolvimento, como a Norte e a Nordeste. Considerações finais: Fatores socioeconômicos desempenham um papel fundamental no desenvolvimento da obesidade no Brasil, destacando a necessidade urgente de políticas públicas que promovam a equidade no acesso a alimentos saudáveis e a ambientes favoráveis à prática de atividades físicas. A criação de programas de prevenção e tratamento direcionados a populações vulneráveis é essencial para conter o avanço da obesidade no país.
A case of incidentally detected spina bifida at DV1 level in a fighter pilot: Aeromedical deliberations
Authors: Rao Neha Arun , Rathore Nandishwar , Suryakiran K , Sekhar M Binu , Ghosh Gaurab
Published: November 2024

A failure of closure neural tube normally results in spina bifida. The lesions may occur anywhere along the spine but are more common in the lumbosacral region (90%) in comparison to the thoracic (6%) or cervical (3%) spines. According to policy guidelines, all cases of spina bifida are unfit for all branches and trades in military flying, except for spina bifida in the sacrum and 5th lumbar vertebra, if completely sacralized. When various congenital defects are considered, spina bifida at the SV1 level is relatively innocuous. However, an anomaly in the upper spinal regions is associated with the narrowing of the spinal canal, which may be accompanied by herniation of meninges. This could be exacerbated and lead to abrupt incapacitation during flight when a spine like this is subjected to high +Gz accelerations or ejection forces. This paper highlights a case of a fighter aircrew who was incidentally detected to have spina bifida at 1st dorsal vertebra level during evaluation for cervical prolapsed intervertebral disc and the aeromedical deliberations for its disposal.
Rare histiocytic neoplasm: A case report
Authors: Genovese Sabrina Maria , Tiefenbach Jakov , Nunna Ravi A. , Youkilis Andrew
Published: November 2024

Background:

Histiocytic neoplasms are defined by too many histiocytes accumulating in various tissues, including the skin, bones, lymph nodes, and central nervous system. They are uncommon blood-related disorders that constitute <1% of cancers found in soft tissues and lymph nodes. Most referred to as Langerhans cell histiocytosis (LCH) or non-LCH, there are over 100 different sub-types that are divided into five groups. Here, a 76-year-old male presented with an intramedullary thoracic LCH.

Case Description:

A 76-year-old male presented with the month of slowly progressive bilateral lower extremity weakness (i.e., right > left) accompanied by decreased left-sided sensation below the T7 level. The enhanced thoracic magnetic resonance (MR) imaging documented an intradural intramedullary nodule at the T5 level with a syrinx extending from C7 to T10. The patient underwent a T4–T6 laminectomy for complete resection of the lesion. CD163 and CD68 studies highlighted a small, spindled-shaped tumor with occasionally enlarged histiocytes without co-positivity for S100. Pathologically, the lesion was considered an isolated intramedullary thoracic LCH.

Conclusion:

A 76-year-old male presented with progressive paraparesis of 1 month’s duration attributed to an enhanced MR-documented T5 single intramedullary T5 thoracic LCH that was successfully resected.
DOES ENTREPRENEURIAL KNOWLEDGE MATTER FOR EDUPRENEURSHIP BEHAVIOR IN TEACHER TRAINING STUDENTS?
Authors: Puddin Khafi , Dalimunthe Muhammad Bukhori , Harahap Lokot Muda , Rinaldi Muammar , Prayogo Rangga Restu , Panggabean Fitri Yani
Published: November 2024

ABSTRACTThis study aims to analyze the construct of the edupreneurship model for teacher training students. Questionnaires were given to students enrolled in the teacher training program at the Faculty of Economics, Universitas Negeri Medan, with a sampling of 275 respondents and an analytical tool for testing the relationship between variables using PLS-SEM. The empirical results found that attitude towards entrepreneurial knowledge proved to have no positive and significant effect; social support for entrepreneurial knowledge is proven to have a positive and significant impact; Self-efficacy on entrepreneurial knowledge is proven to have a positive and significant impact; entrepreneurial knowledge on edupreneurship behavior is proven to have a positive and significant effect.ABSTRAKPenelitian ini bertujuan untuk menganalisis konstruk model edupreneurship pada mahasiswa keguruan. Kuesioner diberikan kepada mahasiswa program keguruan Fakultas Ekonomi di Universitas Negeri Medan dengan total sampel sebanyak 275 responden dan alat analisis untuk menguji hubungan antar variabel menggunakan PLS-SEM. Hasil empiris menemukan bahwa sikap terhadap pengetahuan kewirausahaan terbukti tidak berpengaruh positif dan signifikan; dukungan sosial terhadap pengetahuan kewirausahaan terbukti berpengaruh positif dan signifikan; Efikasi diri terhadap pengetahuan kewirausahaan terbukti berpengaruh positif dan signifikan; Pengetahuan kewirausahaan terhadap perilaku edupreneurship berpengaruh positif dan signifikan.
EVOLVING OF ACCURATE ONLINE PURCHASING MODULE TO IMPROVE STUDENTS' LEARNING OUTCOMES
Authors: Panjawiyati Tika , Astuti Elly , Yusdita Elana Era
Published: November 2024

ABSTRACTThe objectives of this research are (1) the procedure for developing an Accurate Online purchasing module, (2) the quality level of the Accurate Online purchasing module, and (3) the level of effectiveness of the Accurate Online purchasing module. The method used for research and development is Accurate Online Borg & Gall procedure, which is modified into seven stages. The subjects in this research were Accounting Education students at the Universitas PGRI Madiun. Data collection techniques are observation, interview, questionnaires, documentation, and test results. Data processing is done using SPSS. The primary product field test uses a nonequivalent control group design. Student learning test results were analyzed using the Mann-Whitney test. The results of this research indicate that the scientific-based Accurate Online purchasing module that has been developed is declared valid, practical, and effective in improving student learning outcomes.Â Â ABSTRAKTujuan penelitian ini adalah (1) prosedur pengembangan modul pembelian Accurate Online, (2) tingkat kualitas modul pembelian Accurate Online, dan (3) tingkat efektivitas modul pembelian Accurate Online. Metode penelitian dan pengembangan yang digunakan sesuai dengan prosedur Borg & Gall yang dimodifikasi menjadi tujuh tahap. Subyek dalam penelitian ini adalah mahasiswa Pendidikan Akuntansi Universitas PGRI Madiun. Teknik pengumpulan datanya adalah observasi, wawancara, angket, dokumentasi, dan hasil tes. Pengolahan data dilakukan dengan menggunakan SPSS. Uji lapangan produk utama menggunakan desain kelompok kontrol nonekuivalen. Analisis tes hasil belajar siswa dianalisis dengan menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan bahwa modul pembelian Accurate Online berbasis saintifik yang dikembangkan dinyatakan valid, praktis, dan efektif dalam meningkatkan hasil belajar siswa.
ОСОБЕННОСТИ ПРЕПОДАВАНИЯ РУССКОЙ ЛАПТЫ НА УРОКАХ ФИЗИЧЕСКОЙ КУЛЬТУРЫ У ОБУЧАЮЩИХСЯ СТАРШЕГО ШКОЛЬНОГО ВОЗРАСТА
Authors: А.Ю. Костарев , Р.Р. Валлиулина
Published: November 2024

Вовлечение в регулярные занятия физической культурой учащихся старших классов общеобразовательных школ является проблемой, решение которой возможно путем внедрения в процесс обучения на уроках физической культуры новых форм двигательной активности интересных современным школьникам. Практика работы показывает, что занятия русской лаптой на уроках способствуют воспитанию у подростков интереса к активному движению, работе в команде, нацеливают их на регулярные домашние занятия для тренировки основных физически качеств, без которых невозможно добиться успеха в игре. В статье рассматриваются особенности преподавания русской лапты на уроках физической культуры в 10-11 классах общеобразовательной школы.

The involvement of senior secondary school students in regular physical education classes is a problem that can be solved by introducing new forms of motor activity interesting to modern schoolchildren into the learning process at physical education lessons. Work practice shows that Russian lapta classes in the classroom help to educate teenagers in active movement, teamwork, and target them to regular home classes to train basic physical qualities, without which it is impossible to succeed in the game. The article discusses the features of teaching Russian lapta in physical education classes in grades 10-11 of secondary schools.
ЛИЧНОСТНАЯ БЕСПОМОЩНОСТЬ И ПРОАКТИВНОЕ СОВЛАДАНИЕ У ПОЛУЧАТЕЛЕЙ СОЦИАЛЬНЫХ УСЛУГ РАЗЛИЧНОЙ ЭТНИЧЕСКОЙ ПРИНАДЛЕЖНОСТИ
Authors: С.К. Малахаева
Published: November 2024

В исследовании проверяются гипотезы: 1. о наличии статистически значимых различий в проявлениях личностной беспомощности у получателей социальных услуг различной этнической принадлежности: русские, эвенки, якуты; 2. о взаимосвязи между показателями личностной беспомощности и проактивным совладанием. Теоретически уточнены понятия выученная и личностная беспомощность, получатели социальных услуг, трудная жизненная ситуация в условиях, приближенных к Крайнему Северу. Для проверки гипотезы использованы методики «Тест на оптимизм» Л. М. Рудиной; методика «Локус контроля» Дж. Роттера; опросник «Шкала депрессии» Т. И. Балашовой; «Методика измерения уровня тревожности» Дж. Тейлора, адаптированная В. Г. Норакидзе; опросник «Самооценка личности» Г. Н. Казанцевой. Для выявления копинг-стратегий использован опросник «Проактивное совладающее поведение» Э. Грингласс, Р. Шварцер и С. Тауберт, адаптированный Е. С. Старченковой. С помощью дисперсионного анализа выявлены статистически значимые различия между проявлениями личностной беспомощности у русских, якутов и эвенков. Наиболее показательными являются различия в шкалах «коэффициент надежды», «персонализация плохого», «персонализация хорошего», «шкала тревоги», «экстернальности», «интернальности», «самооценки». С помощью корреляционного анализа r-Спирмена выявлена взаимосвязь между уровнем депрессии и проактивным совладанием.

Hypotheses are tested in the study: 1. on the presence of statistically significant differences in the manifestations of personal helplessness among recipients of social services of different ethnicities: Russians, Evenks, Yakuts; 2. on the relationship between indicators of personal helplessness and proactive coping. Theoretically, the concepts of learned and personal helplessness, recipients of social services, and a difficult life situation in conditions close to the Far North are clarified. To test the hypothesis, the methods “Test for optimism” by L. M. Rudina were used; the method “Locus of control” by J. Rotter; questionnaire “Depression scale” by T.I. Balashova; “Method of measuring anxiety level” by J. Taylor, adapted by V.G. Norakidze; questionnaire “Self-assessment of personality” by G.N. Kazantseva. To identify coping strategies, the questionnaire “Proactive coping behavior” by E. Greenglass, R. Schwarzer and S. Taubert, adapted by E.S. Starchenkova, was used. Using the analysis of variance, statistically significant differences between the manifestations of personal helplessness among Russians, Yakuts and Evenks were revealed. The most significant differences are in the scales “coefficient of hope”, “personalization of the bad”, “personalization of the good”, “scale of anxiety”, “externality”, “internality”, “self-esteem”. The correlation analysis of r-Spearman revealed the relationship between the level of depression and proactive coping.
РАЗВИТИЕ ПОБРАТИМСКИХ ОТНОШЕНИЙ МЕЖДУ МУНИЦИПАЛЬНЫМИ ОБРАЗОВАНИЯМИ РЕСПУБЛИКИ САХА (ЯКУТИЯ) И ГОРОДАМИ СЕВЕРО-ВОСТОКА КИТАЙСКОЙ НАРОДНОЙ РЕСПУБЛИКОЙ
Authors: Г.Ф. ЖИРКОВ , Н.В. МЕДВЕДЕВА
Published: November 2024

В статье рассматриваются вопросы развития побратимских отношений между муниципальными образованиями Республики Саха (Якутия) и городами Северо-Востока Китайской Народной Республики. Проанализирована динамика развития и двусторонняя роль рассматриваемых отношений в социально-экономическом развитии территорий, предложены системные меры, направленные на методическое обеспечение деятельности органов местного самоуправления и содействие им в активизации взаимовыгодных побратимских отношений.

The article considers the matters of the development of the twin-city relations between the municipal units of the Republic of Sakha (Yakutia) and the North-Eastern cities of People’s Republic of China. The development dynamics and the bilateral role of considered relations in the social-economic development of the territories have been analyzed. Suggested action framework is aimed at methodical ware and assistance to local government to activate the winning twin-city relations.
О МЕЖРЕГИОНАЛЬНОМ ЭКОНОМИЧЕСКОМ ВЗАИМОДЕЙСТВИИ В ДАЛЬНЕВОСТОЧНОМ ФЕДЕРАЛЬНОМ ОКРУГЕ
Authors: В.В. РУДЬКО-СИЛИВАНОВ
Published: November 2024

В статье предоставлен анализ деятельности Межрегиональной Ассоциации экономического взаимодействия субъектов Российской Федерации Дальний Восток и Забайкалье (МАДВиЗ), примеры лучших практик межрегионального взаимодействия и планы на будущее.

The article provides the analysis of the activities of the Interregional Association for Economic Interaction of the Subjects of the Russian Federation Far East and Transbaikalia (MADViZ), examples of best practices of interregional interaction and future plans.
О РОЛИ НАУЧНОГО ПОТЕНЦИАЛА РЕСПУБЛИКИ САХА (ЯКУТИЯ) В СОЦИАЛЬНО-ЭКОНОМИЧЕСКОМ РАЗВИТИИ АРКТИЧЕСКОЙ ЗОНЫ РЕСПУБЛИКИ САХА (ЯКУТИЯ)
Authors: И.И. КОЛОДЕЗНИКОВ
Published: November 2024

В статье освещена роль научного потенциала Республики Саха (Якутия) в развитии арктической зоны республики. Дан обзор по исполнению Программы комплексных научных исследований в Республике Саха (Якутия), направленных на развитие ее производительных сил и социальной сферы, а также по реализации национального проекта Наука . Исходя из основных целей, на достижение которых направлен нацпроект, обсуждается предложение о включении в федеральный проект Создание сети ведущих научных центров и центров мирового уровня мероприятия по реализации проекта Создание Всемирного центра мамонта в Республике Саха (Якутия) .

The article discusses the role of the scientific potential of the Republic of Sakha (Yakutia) in the development of the Arctic zone of the republic. An overview of the performance is given. Programs of comprehensive scientific research in the Republic of Sakha (Yakutia), aimed at the development of its productive forces and the social sphere, as well as on the implementation of the national project Science. Based on the main goals that the national project aims to achieve, the proposal to include in the federal project Creating a network of leading research centers and worldclass centers activities to implement the project Creating a World Mammoth Center in the Republic of Sakha (Yakutia) is discussed.
ИННОВАЦИОННОЕ РАЗВИТИЕ АРКТИЧЕСКИХ И СЕВЕРНЫХ РЕГИОНОВ ДАЛЬНЕГО ВОСТОКА
Authors: А.Н. ШИШИГИНА
Published: November 2024

В статье рассматриваются проблемы инновационного развития арктических и северных регионов Дальнего Востока России, анализируются факторы, препятствующие повышению инновационной активности предприятий, а также вносятся предложения по отдельным инструментам и механизмам совершенствования инновационной политики.

The article discusses the problems of innovative development of the northern regions of the Far East of Russia, analyzes the factors that hinder the increase in innovative activity of enterprises. Proposals for improving innovation policy in the region were made.
ЭНЕРГЕТИКА АРКТИЧЕСКОЙ ЗОНЫ РЕСПУБЛИКИ САХА (ЯКУТИЯ): ТЕКУЩАЯ СИТУАЦИЯ И ПЕРСПЕКТИВЫ РАЗВИТИЯ
Authors: В.Е. ЗАХАРОВ , А.Е. ИВАНОВА , Т.Н. ПЕТРОВА
Published: November 2024

В статье приводится оценка фактических балансов Арктической зоны Республики Саха (Якутия) за 2012 и 2017 годы. Описание сложившихся условий функционирования и современного состояния систем энергоснабжения, представлены приоритеты инновационного развития в системах энергетики.

The article gives an estimate of the actual energy balance sheets of the Arctic municipal districts of the Republic of Sakha (Yakutia) for 2012 and 2017, describes the prevailing conditions of operation and the current state of power supply systems. The article highlights the priorities of innovative development in energy systems.
РАЗВИТИЕ ТРАНСПОРТНО-ЛОГИСТИЧЕСКОЙ СИСТЕМЫ В АРКТИЧЕСКИХ И СЕВЕРНЫХ РАЙОНАХ РЕСПУБЛИКИ САХА (ЯКУТИЯ) (НА ПРИМЕРЕ ОАО «ТУЙМААДА-АГРОСНАБ»)
Authors: А.И. ВАСИЛЬЕВА , Л.Д. РУМЯНЦЕВА , В.В. СЕМЕНОВА
Published: November 2024

Статья посвящена проблеме удаленности Арктических и Северных районов Якутии от промышленно развитых регионов страны, в том числе развитие транспортнологистической системы. Разработан проект, направленный на развитие данной транспортной инфраструктуры.

The article is devoted to the problem of the remoteness of the Arctic and Northern regions of Yakutia from the industrialized regions of the country, including the development of the transport and logistics system. A draft aimed at the development of this transport infrastructure had been prepared.
О НЕОБХОДИМОСТИ СОВЕРШЕНСТВОВАНИЯ ДЕЙСТВУЮЩИХ МЕР ПОДДЕРЖКИ С УЧЕТОМ СПЕЦИФИКИ АРКТИКИ И КРАЙНЕГО СЕВЕРА
Authors: О.А. БОНДАРЬ
Published: November 2024

представлены тезисы выступления заместителя председателя Комитета Государственной Думы Федерального Собрания Российской Федерации по региональной политике и проблемам Севера и Дальнего Востока. Рассматривается пример адаптации программы «Дальневосточная ипотека» по выдаче гражданам Российской Федерации кредитов на приобретение или строительство жилых помещений на территории Дальневосточного федерального округа под региональные условия рынка недвижимости.

the thesis of the report of the Deputy Chairman of the Committee on Regional Policy and Problems of the North and the Far East of the State Duma Federal Assembly of the Russian Federation is presented. The report discusses the running program “Far East real estate mortgage” which is aimed to issue loans to citizens of the Russian Federation for the purchase or construction of residential premises in the Far Eastern Federal District and argues the need to adapt the program settings to the specific of the regional real estate markets situation.
О ГАРАНТИРОВАННОМ ОБЕСПЕЧЕНИИ ЖИЗНЕННО НЕОБХОДИМЫМИ ТОВАРАМИ НАСЕЛЕНИЯ ОТДАЛЕННЫХ РЕГИОНОВ АРКТИЧЕСКОЙ ЗОНЫ РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Г.И. ДАНЧИКОВА
Published: November 2024

в выступлении обосновывается необходимость совершенствования государственного подхода к проблеме организации северного завоза путем рассмотрения организации северного завоза в качестве обособленной задачи, направленной на повышение уровня жизни населения северных и арктических территорий. Автор рассматривает действующую систему мер по организации завоза жизнеобеспечивающих грузов в труднодоступные районы Севера и предлагает формирование отдельного элемента государственной политики, включая разработку отдельного федерального закона как правовой основы государственной поддержки гарантированного обеспечения населения удаленных северных регионов и Арктики продуктами питания и товарами первой необходимости по приемлемым ценам.

the paper discusses the need to improve the state approaches to the Northern supply system organization. The author argues to consider the Northern supply system the separate organizational task, aimed at the improvement of living standards the North and Arctic zone. The author overviews the working measures of life-support goods supply and delivery system operation to the remote northern regions and proposes to develop a separate element of the state policy, with a new federal law to be a solid legal basis of the state guarantees in the provision of the population of remote Northern and Arctic regions with food and basic necessities at affordable prices.
АКТУАЛЬНЫЕ ВОПРОСЫ ЗАКОНОДАТЕЛЬНОГО ОБЕСПЕЧЕНИЯ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО РАЗВИТИЯ АРКТИЧЕСКОЙ ЗОНЫ РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: А.К. АКИМОВ
Published: November 2024

в докладе рассматриваются основные направления современного состояния нормативного обеспечения государственной политики Российской Федерации в отношении Арктической зоны России, а также основные проблемные вопросы развития Арктики, требующие законодательного регулирования в интересах устойчивого развития.

the report presents the main direction of the regulatory support of the Russian Federation policy in its Arctic zone. The paper presented by the Chairman of the Council of the Arctic and Antarctic under the Federation Council outlines the main problematic issues of the development of the Arctic, which require the legislative regulation to ensure sustainable development.
СОЦИАЛЬНОЕ САМОЧУВСТВИЕ НАСЕЛЕНИЯ РЕСПУБЛИКИ САХА (ЯКУТИЯ): РЕЗУЛЬТАТЫ МОНИТОРИНГА, АНАЛИЗ ДИНАМИКИ, ОПРЕДЕЛЯЮЩИЕ ФАКТОРЫ
Authors: А.Ц. ДОЛГУНОВА
Published: November 2024

В статье изложены результаты исследовательской работы, проведенной в начале2021 года Центром стратегических исследований при Главе Республики Саха (Якутия), по анализу данных ежегодных опросных исследований социального самочувствия населения Республики Саха (Якутия). За многолетний период проанализирована динамика показателей социального самочувствия населения Республики Саха (Якутия) по основным категориям или сферам жизни в разрезе городских округов и муниципальных районов, выделены факторы, оказывающие наибольшее влияние на формирование субъективной оценки удовлетворенности населения, определен круг проблем, выделяемых населением в качестве требующих немедленного решения.

The article presents the results of research work of the Center for Strategic Studies under the Head of the Republic of Sakha (Yakutia) on the analysis of data from annual surveys of social well-being of the population of the Republic of Sakha (Yakutia). For long period analyzed the dynamics of indicators of social well-being of the population of the Republic of Sakha (Yakutia) for the main categories or areas of life, the factors that have the greatest influence on the formation of a subjective assessment of the population’s satisfaction are highlighted, the range of problems identified by the population as requiring an immediate solution has been determined.
АНАЛИЗ ЭКОНОМИЧЕСКОЙ ЦЕЛЕСООБРАЗНОСТИ СХЕМЫ ЗАВОЗА В РАЙОНЫ АРКТИЧЕСКОЙ ЗОНЫ РЕСПУБЛИКИ САХА (ЯКУТИЯ) С ИСПОЛЬЗОВАНИЕМ СЕВЕРНОГО МОРСКОГО ПУТИ
Authors: А.П. ВИНОКУРОВА
Published: November 2024

Статья посвящена анализу значения северного завоза для арктических районов Республики Саха (Якутия), обзору текущего состояния перевозок по Северному морскому пути; в ней представлены результаты изучения регионального опыта использования Северного морского пути и перспективы развития.

The article includes the analysis of importance of northern delivery for the Arctic regions of the Republic of Sakha (Yakutia), an overview of the current state of transportation schemes along the Northern Sea Route; studies the regional experience of using the Northern Sea Route and development prospects.
ИМИДЖ-МОДЕЛИРОВАНИЕ В РЕСПУБЛИКЕ САХА (ЯКУТИЯ)
Authors: И.И. ПОДОЙНИЦЫНА
Published: November 2024

В статье обсуждаются теоретические и эмпирические аспекты территориального маркетинга, подчеркивается важность формирования благоприятного имиджа Республики Саха (Якутия) в общероссийском и мировом масштабах. Автор статьи интерпретирует результаты трех маркетинговых бенчмаркингов, посвященных теме имидж-моделирования региона. Проблема рассматривается в динамике. На основе результатов бенчмаркинга ноября 2023 г. делается вывод о необходимости развития промышленного туризма и туризма заповедных мест, которые будут способствовать продвижению интегрированного имиджа РС (Я), укреплению его позиций. Сделан вывод об актуальных атрибутах имиджа Республики Саха (Якутия)

Theoretical and empirical aspects of the territory marketing are discussed in this article, the importance of formation of favorable image of the Republic of Sakha (Yakutia) in Russian and world scales is underlined. The author of this article interpreters results of three marketing benchmarkings which are devoted to the theme of image-modeling of region. The problem is reviewed in dynamics. The conclusion about significant of development of industry tourism and tourism of unique places is making on the bases of benchmarking of November 2023. These kinds of tourism can promote integrate image of the Republic of Sakha (Yakutia). The conclusion about relevant attributes of image of the Republic of Sakha (Yakutia) have been made.
Analysis of Black Site and Black Spot at Jl. Daeng Manambon-Raden Kusno-Gusti Sulung Lelanang Section, Mempawah
Authors: Ratih Ade , Kadarini S. Nurlaily , Azwansyah Heri
Published: November 2024

Transportation plays a vital role in society by facilitating the movement of people and goods. However, it also brings challenges like traffic congestion and accidents. With urbanization and increased vehicles, road safety has become crucial, as accidents have significant economic and social impacts. Analyzing accident-prone areas helps identify necessary preventive measures. This research was conducted on the 10.1 km Jl. Daeng Manambon-Raden Kusno-Gusti Sulung Lelanang section in Mempawah. Primary data from field surveys includes road conditions, fittings, geometry, and vehicle speeds. Secondary data is traffic accident data (2018-2023) from the Mempawah City Police, analyzed using numerical methods.The Jalan Daeng Manambon-Raden Kusno-Gusti Sulung Lelanang corridor analysis reveals several accident-prone areas (Black Spots) with damaged road features and poor safety facilities. Key findings include deteriorating zebra crossings, speed traps, and traffic signs. High-risk accident locations were identified using Z-Score and Cusum methods. Recommendations include repairing roads, repainting markings, installing better signage, and maintaining clear sightlines. Future studies should focus on more specific interventions and monitoring to improve road safety, following Department of Settlements and Regional Infrastructure guidelines for effective accident reduction
Chemical substitution and band gap tunability in chiral Ag3Au(Se,Te)2 solid solutions
Authors: Won Juyeon , Gutierrez-Amigo Martin , Mattapalli Akhila , Ali Mohammad A. , Shoemaker Daniel P.
Published: November 2024

Ag3AuSe2 and Ag3AuTe2 were previously predicted to be narrow direct gap semiconductors with the same chiral structure type. Recent computational studies using Perdew-Burke-Ernzerhof (PBE) functional highlighted their potential band gap tunability via strain application. For example, Ag3AuSe2 was predicted to exhibit full band closure above 4% tensile strain. In this study, we explored chemical substitution to examine the density functional theory (DFT) predictions, by replacing Se2− with larger Te2− anions. We synthesized and characterized the electronic and optical properties of Ag3Au[Se(1−x)Te(x)]2 solid solutions for x from 0 to 1. Our findings revealed that the lattice constants increase linearly with Te incorporation, reaching 3.6% expansion at 90% Se2− to Te2− substitution. The activation energy and optical band gap of Ag3Au(Se,Te)2 were determined using electrical resistivity and ultraviolet–visible (UV-Vis) diffuse reflectance measurements. The band gap decreased with increasing Te content, although hybrid functionals are necessary to correctly predict the gap. Further computational studies on the band structures of Ag3Au(Se,Te)2 alloys would shed light on the impact of lattice parameter modification via chemical substitution on band gap tunability.
Engineering Photoswitching Dynamics in 3D Photochromic Metal-Organic Frameworks through Metal-Organic Polyhedron Design
Authors: Jin Eunji , Bon Volodymyr , Das Shubhajit , Wonanke A. D. Dinga , Etter Martin , Karlsen Martin A. , De Ankita , Bönisch Nadine , Heine Thomas , Kaskel Stefan
Published: November 2024

Metal-organic polyhedra (MOPs) are versatile supramolecular building blocks for the design of highly porous frame-works by reticular assembly because of their diverse geometries, multiple degrees of freedom regarding functionaliza-tion, and accessible metal sites. Lipophilic functionalization is demonstrated to enable the rational assembly and crystal-lization with photoactive N-donor ligands in an aliphatic solvent to achieve multiaxially aligned photoresponsive dia-rylethene (DTE) moieties in 3D frameworks (DUT-210(M), M= Cu, Rh) featuring cooperative switchability. Combined experimental and theoretical investigations based on in situ-PXRD, UV/Vis spectroscopy and density functional theory calculations demonstrate deliberate kinetic engineering of photoswitchability based on variations in metal-linker bond strengths. The novel porous frameworks are an important step towards the knowledge-based development of photon driven motors, actuators and release systems.
In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury
Authors: Lagiakos H. Rachel , Zou Yefen , Igawa Hideyuki , Therrien Eric , Lawrenz Morgan , Kato Mitsunori , Svensson Mats , Gray Felicia , Jensen Kristian K. , Dahlgren Markus K. , Pelletier Robert D. , Dingley Karen H. , Bell Jeffrey A. , Liu Zhijian , Jiang Yuansong , Zhou Hua , Skene Robert J. , Nie Zhe
Published: November 2024

Dual leucine zipper kinase (DLK), expressed primarily in neuronal cells, is a regulator of neuronal degeneration in response to cellular stress from chronic disease or neuronal injury. This makes it an attractive target for the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis; and neuronal injury, such as chemotherapy induced peripheral neuropathy. Here we describe the discovery of a potent, selective, brain-penetrant DLK inhibitor, KAI-11101 (59). Throughout the program's progression, medicinal chemistry challenges such as potency, hERG inhibition, CNS penetration, CYP3A time-dependent inhibition, and kinase selectivity were overcome through the implementation of cutting-edge in silico tools. KAI-11101 displayed an excellent in vitro safety profile and showed neuroprotective properties in an ex vivo axon fragmentation assay as well as dose-dependent activity in a mouse PD model.
Mechanism of DNA Chemical Denaturation
Authors: Ostrovsky Daniel , Ostrovsky Mikhail
Published: November 2024

We develop the theory of chemical denaturation of DNA for low and medium denaturation degrees, including but not limited to 50% denaturation as a reversible first-order reaction. We show the degree of influence of hydrogen bonding, dispersion, polar forces, proton donor/acceptor ratio, dipole induction, orientation parameter, and electrostatic interaction on the denaturation process of DNA. The absolute enthalpy values for DNA chemical denaturation are significantly lower than in the thermal denaturation process (positive). We show that the mechanism of reaching 50% DNA denaturation thermally and chemically differs. The thermal denaturation process mainly involves breaking hydrogen bonds via heating DNA, while the chemical denaturation process involves replacing DNA hydrogen bonding with denaturants. We also show that hydrogen bonding is the most significant part of the enthalpy of chemical denaturation for T4 bacteriophage DNA, and the proton-donor effect is the dominant mechanism in disrupting hydrogen bonds in DNA denaturation. The influence of this effect is two times larger than the influence of the proton-acceptor effect. Another essential factor for DNA denaturation is the orientational component, part of the polar cohesion parameter. We suggested that the total cohesion parameter measured at 50% of DNA chemical denaturation represents the electrostatic (repulsion) forces maintaining the DNA helix. We demonstrate that theoretical and prior experimental results show that the Hildebrand, Hansen, Karger, Snyder, and Eon equations are applicable and instrumental in studying DNA chemical denaturation. We developed a novel method to reveal and estimate the degree of influence of electrostatic repulsion and different attraction forces in DNA during its chemical denaturation. Our method can be suitable for selecting DNA (or other systems with controllable denaturation) targeted for specific applications.
Light-Induced Conjugation of Inorganic Phosphate and Sulfate with Aminocyclobutenediones under Aqueous Conditions
Authors: Mishiro Kenji , Ogawa Koki , Kobayashi Rena , Okada Nanami
Published: November 2024

Phosphate and sulfate groups play an important role in controlling the physical properties of biomolecules and artificial materials. However, despite their significance, the incorporation of phosphate or sulfate groups into aqueous organic compounds using non-enzymatic methods has been unprecedented. In this study, we have successfully conjugated inorganic phosphate and sulfate with aminocyclobutenedione derivatives via photochemical reactions under aqueous conditions. A plausible mechanism for the conjugation reactions was proposed on the basis of DFT calculations. These reactions will promote life science research based on organophosphates and organosulfates which have been difficult to access up to now.
SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment
Authors: Zhang Junjie , Ge Qingyu , Du Tianpeng , Kuang Yuhao , Fan Zongyao , Jia Xinyi , Gu Wenjin , Chen Zhengsen , Wei Zhongqing , Shen Baixin
Published: November 2024

Interstitial cystitis/bladder pain syndrome (IC/BPS) represents a chronic, aseptic inflammatory bladder condition with an unclear etiology and few therapeutic options. A composite barrier structure composed of the uroepithelium and glycosaminoglycan layer forms on the bladder’s inner surface to block urine and other harmful substances. Dysfunction of this barrier may initiate the pathogenesis of IC/BPS. Sphingosine-1-phosphate (S1P) plays a crucial role in forming tight junctions. Perfusion of S1P into the bladder restored uroepithelial tight junctions in mice with cyclophosphamide-induced acute cystitis and ameliorated symptoms of the lower urinary tract. Mice lacking sphingosine kinase 1 (SHPK1) exhibited more severe bladder injuries and dysfunction. Concurrent in vitro experiments elucidated S1P’s protective effects and its role as a primary messenger through SPHK1 and S1P receptor 1 (S1PR1) knockdown. This study identifies a novel mechanism whereby S1P binding to S1PR1 activates the PPAR-α pathway, thereby enhancing cholesterol transport and restoring tight junctions between uroepithelial cells. These findings elucidate the regulatory role of S1P in the bladder epithelial barrier and highlight a promising therapeutic target for IC/BPS.
Leadership, Organizational Culture, and Work Environment: Drivers Of Employee Discipline
Authors: Putri Diny Ayu Ermalia , Adhimursandi Doddy , Sampeliling Alexander
Published: November 2024

Leadership style, organizational culture, and work environment are crucial factors influencing employees' work discipline. This study investigates these factors' impact on employees' work discipline in the Secretariat Section of the Public Works Department, Kutai Kartanegara Regency, Indonesia. The research employed a quantitative approach with a sample of 75 respondents using the census method for sampling. Data analysis was performed using SEM with SmartPLS Version 4. The findings indicate that leadership style has a positive, although statistically negligible, impact on work discipline. On the other hand, both organizational culture and work environment have positive and statistically significant impacts on work discipline. This study emphasizes proficient leadership, robust corporate culture, and a conducive work environment to foster employee discipline. The findings suggest that organizations should develop participatory and employee-oriented leadership styles, foster a culture of innovation and teamwork, and provide a conducive physical and non-physical work environment to enhance employee discipline and overall organizational performance. This study enhances the comprehension of the variables influencing work discipline in public sector organizations. It provides practical implications for managers and policymakers in designing strategies to improve employee discipline and organizational effectiveness
The Switch of Audit Conceptual Models and Transformation of its Definition at the Current Stage
Authors: Popova A. I.
Published: November 2024

The paper reveals four main stages of formation and development of the audit institute and shows the change of concepts: from confirmatory to system-oriented and from risk-based to crisis-oriented audit. The author analyzed their features and distinctive traits. The study’s aim is to form the latest concept of crisis-oriented audit applied in Russia and the world at the present stage. Also, the author has presented her model of this concept. Auditors in the scientific community widely employ metaphorical characteristics, including “watchdog” in confirmatory audit, “sniffer dog” in system-oriented audit, and “guide dog” in risk-based audit. Furthermore, auditors in a crisis-oriented audit introduce the concept of a “rescue dog” in the scientific community. The methodological basis of the research is the works of Russian and foreign authors. The paper systematized scientific approaches to the definition of “audit” first ever. The author examines the transformation of this definition depending on the development of the audit institution and the emergence of conceptually new audit paradigms. The study concludes that current definitions of “audit” and “digital audit” do not adequately address the challenges faced by the audit institution. The author proposes her own definition of these concepts in the crisis-oriented audit framework. The article also analyzes extra risks inherent in digital audit, both in relation to the auditor and in relation to the audited entity.
Comparative Analysis of the Major Points Under FAS Revenue, RAS 2/2008 Accounting for Construction Contracts, IFRS 15 Revenue on Contracts with Buyers and Recommendations for Refine the Draft Standard
Authors: Suleymanov N. S.
Published: November 2024

The paper is relevant because it addresses the absence of regulatory documents for determining work completion and accounting revenue recognition in non-construction industries. The study aimed to analyze the innovations of the draft FAS Revenue in accounting, specifically regarding revenue and income recognition. It also aimed to identify major discrepancies with the currently applicable IFRS 15 Revenue on Contracts with Buyers and RAS 2/2008 Accounting for Construction Contracts. Also, the work endeavours developing recommendations for refine the draft FAS Revenue on revenue recognition and determining the completion level of work when performing research and development (R&D) under long-term contracts. The author considers new concepts and definitions of the draft standard, considering their probable practical application in modern conditions. The author presents a rationale for the need for priority application of the expert method for assessing the level of completion of R & D under long-term contracts. Based on the principle of rationality and materiality, the author formulates the criteria for recognizing contracts as long-term. Also, the research gives some advice for improving theoretical and organizational-methodological points for accounting of revenue under long-term contracts, ensuring more complete and reliable presentation of accounting (financial) statements. This work’s results can help organizations enhance the quality and reliability of their accounting statements. More over, it can help reduce labor costs associated with preparing these statements using the revenue recognition method. The study used analysis methods, comparison, grouping, the method of analogies, the method of comparison and generalization of regulatory sources and scientific literature on the topic of the study.
Specificity of the Application of the Fixed Price of the EPC-contract for the Construction of Nuclear Power Plant and Facilities Abroad
Authors: Ponomareva Yu. B. , Ishchenko M. M.
Published: November 2024

This study is devoted to approaches to pricing problems during the implementation of nuclear power plant construction projects abroad from the perspective of the nuclear industry’s aspiration to take the place of a global leader. In the course of the work, the issues of client-centricity were considered, the pros and cons of various types of pricing of EPC contracts were analyzed — at fixed, approximate, and mixed prices; the appropriate and corresponding solutions were proposed. Theoretical research methods such as analogy, classification, generalization and comparative analysis, and empirical methods such as modeling and description are used.

The purpose of the study was to determine the main feature, the distinctive property of the application of a fixed price of the EPC contract for the construction of nuclear power plants outside the Russian Federation.

The result of the research was the proposal of two pricing options when working with local contractors, which will be of interest to qualified specialists in the field of pricing of the nuclear industry during the construction of nuclear power plants.