bluuebunny/crossref_metadata_2025 huggingface dataset:
A utilização de livros digitalizados nas aulas online: limites e possibilidades
Authors: De Lima Karla D'angela , Ribeiro Gilvânia
Published: February 2022

A história mostra que a literatura vem, ao longo do tempo, apropriando-se das tecnologias existentes para continuar, cada vez mais, acessível ao leitor. A literatura conta com uma grande variedade de livros infantis em formato de e-book disponível na internet, diante disso vimos a oportunidade de utilizá-los no ambiente escolar. Mesmo que as tecnologias estejam reinventando o livro de literatura, o objetivo deste continua sendo o mesmo: entreter e transmitir conhecimento. Neste artigo, iremos abordar sucintamente a evolução do livro diante das tecnologias existentes e como a literatura se renovou para alcançar as necessidades dos usuários. Depois, faremos um breve levantamento sobre os documentos oficiais da educação brasileira que tratam da literatura infantil e das novas tecnologias digitais nas escolas. Concluindo, assim, com um relato sobre o projeto de leitura: “Viajando na literatura através da web”, que foi adaptado para tempos de distanciamento social, acerca de livros infantis digitalizados com crianças de 6 e 7 anos de uma escola pública em aulas online, numa tentativa de promover o interesse pela literatura infantil.
Infraestructura de los emprendimientos hoteleros en el cantón Quevedo respecto a su demanda
Authors: Boza Valle Jhon Alejandro , Manjarrez Fuentes Nelly Narcisa , Mendoza Vargas Emma Yolanda , Escobar Terán Harold Elber
Published: February 2022

Con la intención de describir los diferentes tipos de emprendimientos hoteleros en la ciudad de Quevedo, respecto del servicio que ofrecen, se recogió información entre los clientes, el objetivo de la investigación consiste en conocer las opiniones sobre la atención y calificación de la estructura con la que cuentas los hoteles estudiados. Las diversificaciones de los servicios hoteleros a nivel general cuentan con una débil estructura, lo que implica consecuencias negativas en los usuarios del servicio, el progreso cultural y económico influye para este crecimiento, en paralelo la demanda ha tenido una evolución sostenida a lo largo del tiempo, avance gradual acorde a estadística internacional. En la misma dirección del servicio es importante para la economía, la afectividad, el carisma y el placer de servir acercará al cliente al hotel. Esta investigación consideró los habitantes de Quevedo y zonas de influencia además de los espacios hoteleros con los que cuenta la ciudad. Se concluye que una buena organización hotelera fidelice a los clientes de forma permanente.
biología molecular y su importancia en la formación académica en el perfil del profesional de la salud.
Authors: Peñafiel Pazmiño Magaly Elizabeth , Vallejo López Alida Bella , Arguello Arguello Franklin Gastón
Published: February 2022

El estudio de la biología molecular en los últimos años, ha ido evolucionando y aportando con nuevos conocimientos al mundo científico, su aplicación ha permitido comprender diversos procesos y funciones que se realizan en la estructura molecular, además de conocer la estructura, función y composición de las moléculas biológicamente importantes, convirtiéndose en uno de los pilares fundamentales para el estudio de las ciencias médicas. En la actualidad, el desarrollo de nuevas tecnologías, proporciona al equipo clínico herramientas clave para realizar un diagnóstico molecular que beneficia al paciente. El objetivo de la presente investigación es analizar la importancia de la enseñanza y aplicación de la Biología Molecular en la formación académica del perfil del profesional de la salud. Se realizó un estudio de revisión bibliográfica de artículos relacionados al tema, en bases de datos electrónicos, science direct, pubmed, (medline) scielo, redalyc, artículos de revistas electrónicas, entre otras y biblioteca virtual de la Universidad de Guayaquil. La biología molecular como área de conocimiento independiente, que busca explicaciones a los problemas de salud, se considera que todas las enfermedades humanas tienen un componente genético: ya sea por un trastorno o por mutaciones en la secuencia de un gen; entre ellas, diabetes, obesidad, preeclampsia, cáncer.
Estudio de la utilización de las TIC en la administración de justicia de la ciudad de Guayaquil
Authors: Coronel Gómez Mercedes Cecilia
Published: February 2022

Este trabajo tiene como objetivo brindar una visión global del estado de formación de los especialistas en los delitos informáticos en la administración de justicia en la sociedad ecuatoriana; en cuanto a su regulación, iniciativas de investigación, tecnología y capacitación del talento humano que investiga dichos delitos, así como también identificar los retos y brechas que debe ser superada por la administración de justicia en la sociedad ecuatoriana para el tratamiento de los mismos. Para la ejecución de este estudio se acogió un diseño cualitativo que consistió en la revisión de bibliografías correspondientes a la temática, investigaciones, documentos oficiales de instituciones públicas, legislación y jurisprudencia nacional e internacional existente en las instituciones que conforman el ordenamiento jurídico ecuatoriano. La técnica utilizada fue el análisis documental y análisis de la información histórica y estadística de entes públicos y privados, así como la investigación descriptiva que se requiere utilizar cuando los procesos tienen una excesiva complejidad y se requiere describirlo del modo más objetivo y minucioso posible, para generar afirmaciones y posiciones. Se abordó el marco conceptual de los delitos y la criminalidad informática y las leyes en la legislación ecuatoriana con la finalidad de establecer la necesidad de estudios Tecnológicos Superiores Informático Jurídico de los operadores de justicia en el Ecuador.
concepción de cliente y su repercusión en la calidad del servicio en el restaurante
Authors: Del Toro Cabrera Aureliano
Published: February 2022

Con la intención de describir la percepción que existe en los restaurantes sobre la calidad del servicio se intercambió criterios con estudiantes, amistades y colegas para saber sus opiniones sobre cómo fueron atendidos durante su estancia en los restaurantes objetos de estudio. Mediante un paradigma interpretativo se analizó la recolección de los datos en diferentes grupos focales teniendo en cuenta las experiencias expuestas por los participantes, que fueron plasmadas mediante un cuaderno de notas. La diversificación de términos como usuario, comensal o consumidor que existen para definir a la persona que acude al restaurante crea confusión, esto produce consecuencias negativas en el personal de servicio, siendo necesario un cambio de percepción donde las personas tienen que reaprender sobre la nueva concepción de cliente basadas en las relaciones interpersonales.
Compromiso organizacional y sentido de pertenencia en docentes: un estudio en una institución educativa pública y privada de Quito-Ecuador
Authors: Manzano Díaz Angélica Geovanna
Published: February 2022

La gestión administrativa en las instituciones educativas tiene el reto de crear herramientas útiles para fortalecer el compromiso organizacional y sentido de pertenencia en los docentes. El objetivo de la investigación fue determinar la relación entre el sentido de pertenencia y el compromiso organizacional de los docentes mediante un estudio comparativo. A través del análisis estadístico de 65 encuestas se describió el nivel de los tres componentes del compromiso organizacional: normativo, continuidad y afectivo; además de los factores afectivo, físico, social y experiencia laboral del sentido de pertenencia en docentes de una institución del sector público y de una institución privada en la ciudad de Quito-Ecuador mediante la aplicación de 65 encuestas. Se determinó que en la institución pública predomina el compromiso normativo dado por el sentimiento de obligación de permanecer en la institución; mientras que, en la institución privada los docentes mostraron un alto nivel de compromiso afectivo. Una educación de calidad implica la adecuada gestión donde los docentes sean gestores de un ambiente laboral orientado al desarrollo personal y profesional comprometidos con su profesión, avances de la ciencia, la tecnología y la evolución de los procesos organizacionales.
Расчет спектра фоторекомбинации при облучении атомов сильным лазерным полем на основе марковского приближения
Authors: Ишханян А.М. , Крайнов В.П.
Published: February 2022

We derived the spectrum of the photon spontaneous emission at the irradiation of atoms by a strong laser field. Our approach is based on the Markoff (factorization) approximation for the total density matrix of the system consisting of an atom, laser field and the vacuum electromagnetic field.
Жесткая фокусировка ультракоротких лазерных импульсов в объем ZnSe
Authors: Гулина Ю.С. , Кудряшов С.И. , Смирнов Н.А. , Кузьмин Е.В.
Published: February 2022

A study of high-NA focusing process of ultrashort laser pulses in bulk of ZnSe has been carried out. It is shown that when focusing laser Gaussian beam with high-aperture lenses into a transparent medium aberration distortions occur leading to an increase in focal spot size. The results of experimental studies on ablation of front and back surfaces of a plane-parallel plate with 4 mm thickness made of ZnSe by laser pulses with a duration of 0.3ps, 1ps, 10ps and a wavelength of 1030nm focused by a micro lens (NA=0.55) are presented. It is shown that at low pulse energies focusing can be considered in a linear mode in which focal spot size is due to aberration distortions.
How Might Changing Climate Limit Cyanobacteria Growth in Shallow Prairie Lakes? An Empirical Space-For-Time Evaluation of the Potential Role of Increasing Sulfate
Authors:   Ecology and Evolutionary Biology Research Cluster , Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary Alberta, Canada, T2N 1N4, Joshi Susan M. , Jackson Leland J. ,   Ecology and Evolutionary Biology Research Cluster , Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary Alberta, Canada, T2N 1N4
Published: February 2022

Cyanobacteria blooms alter aquatic ecosystems and occur frequently in shallow prairie lakes, which are predicted to increase in salinity as the regional climate becomes hotter and drier. However, flat landscapes that experience depression bottom salinity with high concentrations of sulfate in addition to sodium and chloride, may mitigate nutrient increases or even inhibit cyanobacteria growth. Cyanobacteria can dominate shallow lakes with low N:P ratios because many cyanobacteria species fix dissolved N2, whether due to in-lake denitrification or exchange with the atmosphere, a process that requires molybdenum as an enzyme cofactor. Sulfate can compete with molybdate at cellular uptake sites, potentially limiting the competitive advantage of cyanobacteria. We studied 25 lakes located in a relatively limited geographic region of southern Alberta (Canada) and used a space-for-time analysis to model scenarios of increased sulfate concentrations under changing climate. Monthly, we measured nitrogen, phosphorus, sulfate, molybdenum, and cyanobacterial pigments and used mixed effects models to identify empirical relationships. Sulfate drives conductivity in the region and we found that most saline lakes we sampled are turbid lakes with high nutrients and high cyanobacteria biomass. In addition to phosphorus, molybdenum predicted cyanobacterial pigments in the top two models, showing a positive relationship with cyanobacterial biomass. We also found a negative relationship between sulfate concentration and cyanobacteria pigments, which suggests that as lakes get saltier, even with increased nutrients, there may not be an incremental increase in cyanobacteria biomass. Our results therefore suggest that competition between sulfate and molybdate may limit future cyanobacteria growth in shallow lakes and that with a warmer and drier climate it may not be inevitable that shallow lakes will continue to be dominated by cyanobacterial blooms, a hypothesis that could be tested directly via experimentation.
Experimental Phenomenology as Personalized Health Intervention: A Case Illustration
Authors:   Department of Psychology, Lund University, Box 213, 221 00 Lund, Sweden, Lundh Lars-Gunnar
Published: February 2022

Experimental phenomenology is the investigation of phenomenological practices and their effects. To engage in a phenomenological practice means to focus attention on aspects of one’s experiences (e.g., sense impressions or body sensations) while adopting a specific kind of attitude (e.g., an explorative attitude) according to some set of instructions. The basic assumption is that the regulation of attention and attitudes involved in such practices may have effects on people’s health and quality of life. The present paper describes the basic principles of experimental phenomenology as an approach to personalized health interventions and illustrates these principles with a case, where a mindful embodiment practice was constructed for an individual suffering from insomnia due to early morning awakenings. The results are discussed in terms of the importance of personalization, the ambition to formulate general conclusions about the effects of phenomenological practices, and the need for measurements not only before and after treatment but also during the treatment process.
Effect of the Nutraceutical Micodigest 2.0 on the Complication Rate of Colorectal Cancer Surgery With Curative Intent: Protocol for a Placebo-Controlled Double-blind Randomized Clinical Trial
Authors: Regueiro Cristina , Codesido Laura , García-Nimo Laura , Zarraquiños Sara , Remedios David , Rodríguez-Blanco Arturo , Sinde Esteban , Fernández-de-Ana Catalina , Cubiella Joaquín
Published: February 2022

Background

Most colorectal cancer patients diagnosed are candidates for surgical resection with curative intent, although colorectal surgery is associated with some complications that could be life-threatening. Antibiotic prophylaxis is commonly used for the prevention of infectious postoperative complications. However, this intervention can change the composition of intestinal microbiota and promote adverse inflammatory outcomes in colorectal cancer patients. The combination of different fungal extracts could be beneficial because of their role in gut microbiota modulation and their anti-inflammatory activity.

Objective

Based on this hypothesis, we have designed a double-bind, randomized clinical trial to evaluate the effect of the nutraceutical fungal extract Micodigest 2.0 on complications of surgery for colorectal cancer resection.

Methods

Colorectal cancer candidates for surgery will be considered for inclusion in the study. After evaluation by the multidisciplinary tumor board, patients who meet selection criteria will be screened, stratified according to tumor location, and randomly allocated to be treated with Micodigest 2.0 or placebo. Treatment will be continued until admission for surgery (4-6 weeks). Participants will undergo a medical and clinical evaluation including baseline and preadmission quality of life, microbiome composition, inflammatory and nutritional status, adverse events, and adherence assessments. The main end point of the study is the surgery complication rate. We will evaluate complications using the Clavien-Dindo classification. It will be necessary to recruit 144 patients to find a relevant clinical difference. We will also evaluate the effect of the nutraceutical on microbiome composition, inflammatory response, nutritional status, and quality of life, as well as the effect of these variables on surgical complications.

Results

This study was funded in 2020 by the Center for Industrial Technology Development. Recruitment began in September 2021 and is expected to be completed in September 2022. Data will be analyzed and the results will be disseminated in 2023.

Conclusions

The results of this protocol study could help to reduce surgery complications in patients with colorectal cancer using the new treatment Micodigest. This study could also identify new features associated with colorectal surgery complications. In summary, this study trial could improve the management of colorectal cancer patients.

Trial Registration

Clinical Trials.gov NCT04821258; https://clinicaltrials.gov/ct2/show/NCT04821258

International Registered Report Identifier (IRRID)

DERR1-10.2196/34292
La evaluación docente como dispositivo de seducción. ¿Negarse también es resistir?
Authors: Anaya-Torres Edgar-Daniel , Galaz-Ruíz Alberto
Published: February 2022

Este artículo realiza un análisis sobre la evaluación docente en tres momentos. El primero aborda una descripción histórico-política sobre sus antecedentes, articulaciones con organismos internacionales y políticas educativas en México y Chile. El segundo entrama un análisis hermenéutico que establece la relación del docente como sujeto de rendimiento, resultado de la evaluación e instrumentos específicos como: Perfiles, Parámetros e Indicadores (PPI) en México, y el Marco para la buena enseñanza (MBE), desde categorías enunciadas por Foucault y Han. Finalmente, en un tercer momento, se evidencian las grietas para repensar las subjetividades dentro del sistema educativo en general y el de la evaluación en particular.
Decoding the Clinical and Laboratory Parameters of COVID-19 and Dengue Co-infection
Authors: Swapnamanjari C.V. , Gopinathan Anusha , Leela K.V.
Published: February 2022

Severe acute respiratory diseases caused by coronavirus disease 2019 (COVID-19) have caused infections around the world, and this disease has been declared a global pandemic by the World Health Organization. COVID-19 has severely impacted the world economy, and as it has multiple unnoticeable transmission routes, it can derail the health care system for a long time. Most states in India are affected by the COVID pandemic. As India is known for its seasonal infections such as dengue, leptospirosis, influenza, malaria, and enteric fever, it is expected that these infections may co-exist. Coinfection of these two viral infections causes challenges in diagnosis and treatment, especially in places with limited resources. Antibody-mediated enhancement of the immune response is a cause for concern in co-infection of COVID-19 and dengue. The present article discusses the clinical features, serological cross reactions, and antibody-dependent enhancement of COVID-19 coinfection with dengue infection.
Analyzing the Effect of Need for Achievement and Locus of Control on Student Entrepreneurial Intentions
Authors: EKAWARNA EKAWARNA , ANRA YUSDI , AYUN QUROTTA , ROMIOS SERI , TARNAK TARNAK
Published: February 2022

This study aimed to analyze the student entrepreneurial intentions model based on their psychological characteristics. More specifically, this study sought to explain whether the Need for Achievement (N-Ach) and Locus of Control (LoC) of students had an effect on Entrepreneurial Intentions (EI). An inferential research design with a cross-sectional study was adopted to collect the data. Students from faculty of teacher training and education, one public university in Jambi, were involved as the sample of the study. 63.14% of male students were selected by using a simple random sampling strategy, dominated by 81.78% of respondents aged less than 20 years. Data were collected through questionnaires and were analyzed by using the statistical correlation software and linear regression models to ensure the relationship between psychological characteristics and EI. The results indicated that there was a positive effect on psychological characteristics and EI on Student Entrepreneurial Intentions. N-Ach and LoC positively affected EI, both partially and jointly. Due to the limited instrument used in this study, only a self-reported questionnaire, which carried an opportunity for the response bias, and involved male students from a faculty in one public university in Jambi. Therefore, this model needs a further development through the incorporation of behavioral characteristics by involving larger samples allowing us understand on whether behavioral theories and traits are conflicting or complementary.
The Correlation between school principal leadership competence and teachers’ social behaviours
Authors: YASIN BURHANUDDIN , MUSTAFA FAISAL
Published: February 2022

It has been predicted that the leadership competence of school principals indirectly influences the achievements of students because it has a positive impact on the social behaviour of their teachers. However, the correlation between those variables has not been supported by data. This research was therefore aimed at finding evidence for any correlations between the leadership competence of principals and the social behaviour of teachers under them. The samples were selected randomly, resulting in the selection of 110 EFL teachers in the Province of Aceh, Indonesia. The data for this study were collected using two questionnaires, a questionnaire about the social behaviour of teachers and a questionnaire rating the leadership competence of school principals. The data were analyzed using the Spearman correlation formula at significance level of 0.05. The results showed that almost all the constructs for leadership competence of principals were correlated to all the constructs of social behaviour of teachers at low level (0-0.29, p-value < 0.05) and moderate level (0.30 – 0.49, p-value < 0.05) of correlation. It was unexpected that teachers’ punctuality and accountability was not well-correlated to leadership competence of principals (p-value > 0.05). Based on the research results, it is recommended that the recruitment of school principals involve a standardized test consisting of all constructs of leadership competence.
The Extent of Principals’ Empowerment and Their Functions towards Management of Public Elementary Schools
Authors: ANJELICA P. RIVERA PAULA , P. IBARRA FLORANTE
Published: February 2022

This study examined the relationship between the extent of empowerment of public elementary school principals and their functions towards school management in the District of Aliaga, Nueva Ecija, Philippines. 18 public elementary principals/school heads were involved. Anchored on Zimmerman’s (2000) empowerment theory, both process and outcomes-based empowerment had been carefully assessed. This lens provided principles and framework in looking at processes such as individual action and engagement activities within a particular social context.  Survey questionnaire was used involving statements measured through Likert scale. With a six-month period of data gathering, Pearson r was utilized in the analysis.  Results revealed that instructional (r=.408, p <0.01) and administrative empowerments (r=.776, p <0.01) established highly significant relationships with school safety and orderliness, opportunities to learn, time on task and instructional leadership respectively. Recommendations on sustainability of quality instruction in relation to school-based management are further taken into account as these might likewise impact the teaching and learning process to enhancing the identity of instructional leadership.
Managing Young Human Resource Behaviors through Character Education
Authors: Asad Asad , Fridiyanto Fridiyanto
Published: February 2022

The purpose of this research was to explore what efforts were being made by the Madrasah Tsanawiyah Bungo Regency in order to foster and embed character education in their students, in particular; how to plan, implement, supervise, and evaluate character education for students in One State Madrasah Tsanawiyah Bungo Regency. This research was a qualitative research with a case study approach. In collecting the data, the researcher used a demographic background and an in-depth interview with 9 participants. The participants in this research were one principal, two vice principals, three teachers, and three students. Based on the findings of the research, it concluded the design of this education plan had been carried out periodically from the beginning of the year by perfecting the plan of the previous year and continued by making a plan for the following year which was carried out by a deliberation meeting with the teacher assembly and entered into the education calendar. The finding related to the implementation of character education was carried out by integrating character education into daily activities at the madrasah and building communication between schools with parents of students. Furthermore, the finding of supervision showed that each party in the school such as the principal, vice-principals and teachers played an active role in supervising both directly and indirectly. The teacher was the party that had an active role because the teacher in addition to overseeing student actions, teacher also taught about how to inculcate character education in the classroom so that it can improve student behaviors by giving a warning.  In terms of evaluation, it showed that the learning process of character education had been going quite well and in accordance with what was expected even though there were still shortcomings such as there were teachers who still did not understand the materials well, so the learning process was still less interesting and satisfying, especially in religious learning.
Construction of Mathematical Communication Schemes Based on Learning Styles
Authors: Maulyda Mohammad Archi , Erfan Muhammad , Wulandari Nourma Pramestie , HIdayati Vivi Rachmatul , Umar Umar
Published: February 2022

The purpose of this study was to describe the construction of students’ mathematical communication in solving problems based on students’ learning styles. This research method is qualitative-descriptive. The subjects in this research were three students, each of these students are theoretical, reflective, and pragmatic learning styles. The research instrument used was mathematics problems with a topic similarity. The data obtained were in the form of students’ work and short unstructured interviews. The data were analyzed based on indicators of problem-solving and mathematical communication. The results showed that students with theoretical learning styles could communicate the entire process of the problem-solving well. Students with a reflective learning style could show a good problem-solving process. Even so, mathematical communication is not very clear. Students with a pragmatic learning style had a poor performance in solving problems. The mathematical communication is also not very good.
The innovative design of automatic speed limiter device for trucks and buses based on road location analysis
Authors: Pranoto Hadi , Leman Abdul Mutalib , Feriyanto Dafit , Adriansyah Andi , Wahab Abdi
Published: February 2022

The increasing number of vehicles every year has led to the rising potential of vehicle accidents. In 2015, there were 556 fatalities from 6,231 accident cases occurred in Jakarta, through regulation of the Minister of Transportation Republic Indonesia No: 111 in 2015, it has been issued firm vehicle speed restrictions, but there is no positive impact because the speed limit of each vehicle cannot be done automatically by the highway location, so the need for innovation to design a tool that can meet these needs. The method in this research is developing a device that can break the flow of fuel quickly to hold the vehicle's speed with a Global Positioning System (GPS) as a trigger to drive the relay that has been installed on the engine. The results of this study are devices that have been installed in truck and bus engines capable of holding the speed. The result shows that the voltage has been calculated was at 10 km/h produce 1.2 volts, and the highest speed of 70km/h produce 10.7 Volt. GPS in speed limiter is also compared with the Map application. The result shows a slight difference either in latitude or longitude, where the smallest differences in latitude and longitude were about 0.00" and 0.05", respectively. In addition, the GPS speed limiter well performs to limit the speed of trucks and buses for 32 km/h in pedestrians, 58km/h on the highway and 52 km/h on a toll road.
Effects of 1-hexyl-1-methylimidazolium iodide ionic liquid to poly(vinyl alcohol)–based solid polymer electrolyte
Authors: Ratri Christin Rina , Sabrina Qolby , Lestariningsih Titik , Zakiyyah Salsabila
Published: February 2022

A solid polymer electrolyte (SPE) membrane has been fabricated using poly (vinyl alcohol) (PVA) as polymer host dissolved in deionized (DI) water. Lithium bis(oxalato) borate (LiBOB) electrolyte salt and 1-hexyl 1-methylimidazolium iodide (HMII) are incorporated into the membrane to contribute free ions, enhancing ionic conductivity. SPE was produced using the solution cast technique on Petri dishes. Then these slurries were dried at room temperature. The final product is a self-standing opaque membrane with visually homogenous surfaces. Further observation using FE-SEM revealed magnified images of membrane surfaces and cross-sections. Molecule interaction and crystallinity were observed using FT-IR and XRD. Impedance measured using EIS was used to calculate ionic conductivity. It was found that ionic conductivity of pure PVA film was 3.9×10-7 S/cm while ionic conductivity of SPE before and after ionic liquid addition was 4.77×10-7 S/cm and 2.66×10-6 S/cm.
Novel Gene Abnormality in Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome)
Authors: Magsi Rayan , Ryan Casey , Sheikh Ajaz , Noor Mariam , Mahfooz Naeem
Published: February 2022

We present an 8-year-old with absence, generalize tonic-clonic and
myotonic-atonic seizures who was diagnosed with Doose syndrome based on
clinical presentation and EEG findings. A genetic panel found a SUOX
gene mutation which has not yet been correlated with Doose syndrome. Her
presentation does not resemble known SUOX related disorders.
Melanic morphs of Batrocera dorsalis, (Hendel) (Diptera: Tephritidae) possess distinct developmental time, weight, wing size and shape
Authors: Mwando Nelson , Baleba Steve B. S. , Ndlela Shepard , Mohamed Samira
Published: February 2022

The Scutum of Bactrocera dorsalis individuals shows a high degree of
variability in their colouration, which goes from black to brown. Such
variation depicts a different level of melanin production in these
individuals. Here we asked whether the progeny produced by four melanic
morphs of B. dorsalis would present a difference in their developmental
time, weight, wing size and shapes. To address this, we followed eggs
produced by gravid females of each B. dorsalis melanic morphs by
recording their pupation time, emergence time, and larval, pupal and
adult weights. Also using the landmark-based geometric morphometric
analysis we assessed the variation in wing size and shape of the adults
obtained from each parental melanic morphs of B. dorsalis. We found that
larvae produced by adults with dark scutum exhibited faster development
and weighed more than those produced by adults with brown scutum. At
adult stages, individuals from parents with darker and brown scutum had
a reduced weight and wing size (length, width, area and centroid size)
as compared to those from the parents with moderate melanin production.
We also found a significant wing shape variation across the four melanic
morphs. Our study shows that melanisation in the scutum of B. dorsalis
has a fitness gain in the preimaginal stages of this fly. While in the
adult stage, the heavier or the lesser melanin production in the scutum
has a fitness cost. This suggests that there is a trade-off between
melanin production and other fitness parameters in B. dorsalis which
could have implication on its flight and dispersal and consequently, its
management.
Estudio de los pueblos mágicos en México: el caso del municipio de Chignahuapan, Puebla
Authors: Pérez Paredes Alfredo , Juárez Fonseca Verónica , Torralba-Flores Amado
Published: February 2022

Problemática: en México, la denominación de pueblos se realizó con los propósitos de fortalecer a las comunidades y de mejorar la competitividad de las empresas, las condiciones laborales de sus trabajadores y la calidad de vida de la comunidad. Sin embargo, al paso de los años se observa que esto no ocurre. Objetivos: estudiar al municipio de Chignahuapan desde la mirada socioeconómica y cultural del turismo y contribuir con propuestas al fortalecimiento de la comunidad. Materiales y métodos: el tipo de investigación fue cuantitativa, toda vez que se aplicaron cuatro tipos de encuestas, así como la indagación documental, que confluyeron para la construcción del marco conceptual. Resultados: los principales resultados encontrados por parte del gobierno municipal indican que a causa de la denominación de pueblo cuentan con recursos adicionales. En lo correspondiente a los visitantes, se encontró que el 100 % de estos son mexicanos y que las calificaciones por el servicio recibido no son las mejores. En cuanto a los ciudadanos, estos consideran que la denominación de pueblo no ha incrementado el turismo y tampoco ha disminuido las actividades productivas tradicionales. Discusión: de los múltiples resultados explorados se encontró que, en el tema de la economía, la ciudadanía considera que el turismo en efecto ha contribuido al crecimiento del empleo, aunque esta contribución es temporal y no ha mejorado la calidad de vida de los habitantes. Conclusiones: se concluye que hay una necesidad de darle mayor visibilidad a la comunidad para incrementar la afluencia turística y con ello contribuir a mejorar el nivel de vida de los habitantes de tan importante lugar. Contribución/originalidad: la presente contribución se considera original, toda vez que no se han encontrado investigaciones con estas características sobre las implicaciones de la denominación de pueblo mágico para la comunidad de Chignahuapan.
The Textual Transmission of Iter Buda Hadrianopolim, a Travelogue by Antun Vrančić
Authors: Sorić Diana , Serreqi Jurić Teuta
Published: February 2022

Croatian humanist,
diplomat, and prelate Antun Vrančić (1504-1573) produced a number of literary
works, among which the travelogue Iter
Buda Hadrianopolim holds a special place, since it was written as a
testimony of Vrančić’s first mission to Constantinople (1553-1557), on which he
was sent by order of Emperor Ferdinand I (1503-1564). The text is preserved in
the form of Vrančić’s autograph and three transcripts as part of the
geographical and historical work De
Illyrico Caesaribusque Illyricis by Croatian humanist Ivan Tomko Mrnavić
(1580-1637), and was published twice, in the 18th and 19th
centuries. This paper provides an insight into the textual transmission of the Iter Buda Hadrianopolim based on the
findings the authors arrived at while preparing a critical edition of this text
by Vrančić. A philological comparison of Vrančić’s manuscript and the preserved
transcripts provides an answer to the question which copy is closest to
Vrančić’s original, while a comparison of the manuscript and editions indicates
that the existing editions are unreliable for linguistic, stylistic, or
historiographical research due to errors which hinder the correct reading of
the text. This, along with the fact that no critical edition of the text
exists, is why a new philological treatment of this text by Vrančić according
to the principles of modern neo-Latin studies was necessary.
Lifetime Cardiovascular Disease Risk by Coronary Artery Calcium Score in Individuals With and Without Diabetes: An Analysis From the Multi-Ethnic Study of Atherosclerosis
Authors: Ferket Bart S. , Hunink M.G. Myriam , Masharani Umesh , Max Wendy , Yeboah Joseph , Burke Gregory L. , Fleischmann Kirsten E.
Published: February 2022

Objective

To assess lifetime cardiovascular
disease (CVD) risks by coronary artery calcium (CAC) scores in individuals with
diabetes from the Multi-Ethnic Study of Atherosclerosis (MESA) and compare
risks with those without diabetes.

Research Design and Methods

We developed a microsimulation
model with ‘Well’, ‘Diabetes’, ‘Post CVD’, and ‘Death’ health states using multivariable
time-dependent Cox regression with age as time scale. We initially used 10-year
follow-up data of 6769 MESA participants including coronary heart disease
(N=272), heart failure (N=201), stroke (N=186), and competing death (N=272),
and assessed predictive validity at 15 years. We externally validated the model
in matched National Health and Nutrition Examination Survey (NHANES) participants.
Subsequently we predicted CVD risk until age 100 by diabetes, 10-year Pooled
Cohort Equations risk, and CAC score categories (0, 1-100, 100+).

Results

The model showed good calibration
and discriminative performance at 15 years with discrimination indices 0.71-0.78
across outcomes. In the NHANES cohort, predicted 15-year mortality risk corresponded
well with Kaplan-Meier risks, especially for those with diabetes: 29.6% (95% CI
24.9-34.8) vs 32.4% (95% CI 27.2-37.2), respectively. Diabetes increased
lifetime CVD risk similar to shifting one CAC category upwards (from 0 to 1-100
or from 1-100 to 100+). Patients with diabetes and zero CAC scores had lifetime
CVD risks that overlapped with those without diabetes who are at low 10-year Pooled
Cohort Equations risk <7.5%.

Conclusions

Patients with diabetes carry a spectrum of CVD risk. CAC
scoring may improve decisions for preventive interventions for patients with
diabetes by better delineating lifetime CVD risks.
Müller Glial Expression of REDD1 is Required for Retinal Neurodegeneration and Visual Dysfunction in Diabetic Mice
Authors: Miller William P. , Toro Allyson L. , Sunilkumar Siddharth , Stevens Shaunaci A. , VanCleave Ashley M. , Williamson David L. , Barber Alistair J. , Dennis Michael D.
Published: February 2022

Clinical
studies support a role for the protein regulated in development and DNA damage
response 1 (REDD1) in ischemic retinal complications. To better understand how REDD1 contributes to retinal
pathology, we examined human single cell sequencing datasets and found
specificity of REDD1 expression that was consistent with markers of retinal
Müller glia. Thus, we investigated the hypothesis that REDD1 expression
specifically in Müller
glia contributes to diabetes-induced retinal pathology. The retina of Müller glia specific REDD1
knockout (REDD1 mgKO) mice exhibited dramatic attenuation of REDD1 transcript
and protein expression. In the retina of streptozotocin-induced diabetic
control mice, REDD1 protein expression was enhanced coincident with an increase
in oxidative stress.
In the retina of diabetic REDD1 mgKO mice there was no increase in REDD1
protein expression and oxidative stress was reduced as compared to diabetic control
mice. In both Müller glia within the retina of diabetic mice and human Müller cell cultures exposed to hyperglycemic conditions,
REDD1 was necessary for increased expression of the gliosis marker glial
fibrillary acidic protein.
The effect
of REDD1 deletion in preventing gliosis was associated with suppression of
oxidative stress and required the antioxidant transcription factor Nrf2. In contrast to diabetic control mice, diabetic
REDD1 mgKO mice did not exhibit retinal thinning, increased markers of
neurodegeneration within the retinal ganglion cell layer, or deficits in visual
function. Overall, the findings support a key role for Müller glial REDD1 in the
failed adaptive response of the retina to diabetes that includes gliosis,
neurodegeneration, and impaired vision.
Pars Plana Vitrectomy in Rhegmatogenous Retinal Detachment in Paediatric Patients in Dr. Cipto Mangunkusumo Hospital, Indonesia 2017
Authors: Hilda Faresa , Djatikusumo Ari , Elvioza Elvioza , Adriono Gitalisa Andayani , Yudantha Anggun Rama , Hutapea Mario Marbungaran , Victor Andi Arus
Published: February 2022

In the past decades, indications for PPV in paediatric patients has been rising with large heterogeneity outcomes among studies. Our objective is to present a pilot descriptive study in Indonesia, regarding pars plana vitrectomy (PPV) success rate in paediatric patients with rhegmatogenous retinal detachment (RRD) in Dr. Cipto Mangunkusumo Hospital (CMH). A retrospective study was conducted on 16 paediatric eyes diagnosed for RRD and treated in CMH during the period of January 2017 to December 2017. A total of 16 RRD eyes were identified in 15 individuals. Majority of the patients were male and were in the age group of 12-18 years. There were 13 patients undergone PPV with or without SB. Functional anatomical success rate was determined from the macula status while functional success rate on final BCVA. Among 16 patients, 14 had constant or increased final BCVA and 11 had reattached macula. The success rate of PPV in terms of anatomical outcome was 11 out of 16 eyes and in functional outcome was 8 out of 16 eyes.
Keywords: pars plana vitrectomy, paediatric ophthalmology, rhegmatogenous retinal detachment.
 
Karakteristik dan Hasil Vitrektomi Pars Plana pada Pasien Pediatrik di Divisi Vitreoretina Rumah Sakit Cipto Mangunkusumo Tahun 2017
Abstrak
Indikasi tindakan vitrektomi pars plana (PPV) pada pasien pediatrik bertambah secara signifikan dalam beberapa dekade terakhir. Penelitian ini dilakukan sebagai studi awal di Indonesia, terkait tingkat keberhasilan PPV pada pasien anak dengan rhegmatogenous retinal detachment (RRD) khususnya di RS Cipto Mangunkusumo (RSCM). Studi retrospektif dilakukan terhadap 16 mata RRD pada 15 pasien anak di RSCM pada periode Januari 2017 – Desember 2017. Mayoritas pasien merupakan laki-laki dalam kelompok umur 12-18 tahun. Terdapat 13 pasien yang menjalani PPV dengan atau tanpa scleral buckle (SB). Tingkat keberhasilan anatomi dilihat dari status penempelan makula, sementara tingkat keberhasilan fungsional dinilai dari visus akhir. Tingkat keberhasilan anatomi PPV dalam studi ini adalah 11/16 mata, dan tingkat keberhasilan fungsional mencapai 8/16 mata.
Kata kunci: vitrektomi pars plana, oftalmologi pediatrik, rhegmatogenous retinal detachment.
Mitochondrial Adaptations of Obese Adult Rat Visceral Adipocytes which Differ in Nutritional Status during Childhood
Authors: Nasution Lailan Safina , Aulia Ahmad , Jusman Sri Widia A. , Sadikin Mohamad
Published: February 2022

Mitochondria are highly dynamic organelles that can adapt to different environmental stimuli. This study aims to analyze differences in the function and biogenesis of mitochondria and anaerobic glycolysis activity between obese adult rats that were undernourished in childhood (LCD28) and those which were normal (SD28) or already fat (HFD28). Sprague-dawley rats were assigned groups and given diet treatments from December 2017 until August 2018 in the Laboratory Animal Management Unit, Faculty of Veterinary Medicine, Bogor Agricultural Institute. To observe mitochondrial function and biogenesis, MnSOD activity and PGC1α levels were analyzed using ELISA. To investigate the existence of anaerobic glycolysis, LDH activity was analyzed using a spectrophotometry method. The results showed that MnSOD activity and PGC1α levels of LCD28 increased compared to the other groups, signifying higher mitochondrial function and biogenesis. Meanwhile, no significant difference in LDH activity was found, signifying similar levels of anaerobic glycolysis.
Evaluation of Traumatic Corneal Rupture Treatment Outcome in dr. Cipto Mangunkusumo Hospital: Two Years Retrospective Study
Authors: Hayatulhaya Brenda , Widyawati Syska
Published: February 2022

Open globe injury is an injury that requires prompt treatment which could predict the final outcome. This study evaluates the characteristics and outcome of corneal rupture management in dr. Cipto Mangunkusumo National Hospital’s emergency room. We conducted a retrospective study based on the patient’s medical record between January 2016 – December 2017. Data regarding patients’ demographic, clinical characteristics according to Birmingham Eye Trauma Terminology Score (BETTS) criteria, duration of trauma to surgery, use of early topical steroid, one month visual function result, and risk of endophthalmitis were collected. A repeated ANOVA test with posthoc Bonferroni was used to compare the mean of a paired numeric variable. A total of 163 patients with corneal rupture were recorded, consisted of mostly male (92%) and median age of 27 years old. We found 36.8% cases occurred in the household, 71% cases in the zone I, 62.6% penetrating cases, and mostly came with 4/200-light perception visual acuity (VA) for all zones, mostly caused by inorganic materials and 50.9% cases involved lens. Endophthalmitis was higher in inorganic causes (69.2% vs 30.8%, p=0.33). A total of 95.2% of cases performed surgical treatment in < 24 hours. In post-operative follow up, 53.3% of cases did not need re-operation or proceeding surgery. Several risk factors might affect the treatment outcome of eye injury. Most rupture occurred at zone I. Administration of topical steroids directly post-surgery was not associated with the incidence of endophthalmitis.
The influence of GLP-1R agonists on glucose-stimulated insulin secretion and the receptor internalisation in normal, diabetic and recovered pancreatic beta-cells
Authors:   , Reed Joshua
Published: February 2022

Type 2 diabetes (T2D), which has become a global pandemic in recent decades, is a metabolic disease largely characterised by impaired insulin secretion and action in patients. Glucagon-like peptide (GLP)-1 is an incretin hormone responsible for augmenting insulin secretion from pancreatic beta-cells during the postprandial period. Given that native GLP-1 has a very short half-life, GLP-1 mimetics have been developed, which have a much greater duration of action, and are currently an effective treatment option for T2D by prolonging insulin secretion in patients. Additionally, there is continuing emerging evidence that these therapies alleviate the post-diagnosis complications of T2D to a greater extent than other treatments. Current GLP-1 based therapies all act as orthosteric agonists for the GLP-1 receptor (GLP-1R). Interestingly, it has emerged that GLP-1R also has allosteric binding sites and agonists have been developed for these sites. The objective of this study was to determine if allosteric agonists had superior effects on insulin secretion compared to orthosteric, and could therefore be a more effective treatment for T2D. Rat pancreatic beta-cell lines (INS-1E and INS-1 832/3) have been shown to mimic native islet beta-cell behaviour, and therefore in vitro experiments carried out with these cell lines in this study have clinical relevance. This study demonstrated how INS-1E and INS-1 832/3 cells responded to varying treatments with both types of GLP-1R agonists and the differential mechanisms by which these agonists mediated their actions. Additionally, how cells responded to treatments depending on whether they are in healthy, diabetic or recovered states was assessed to demonstrate how islet beta-cells’ response can be altered depending on the conditions they have been chronically exposed to pre-treatment. Overall, findings from this study demonstrate that allosteric agonists have a superior duration of action and the mechanisms by which both types of agonist exert their actions are distinct.