bluuebunny/crossref_metadata_2025 huggingface dataset:
Relevant Aspects of the Dental Implant Design on the Insertion Torque, Resonance Frequency Analysis (RFA) and Micromobility: An In Vitro Study
Authors: Herrero-Climent Mariano , Falcao Artur , Tondela Joao , Brizuela Aritza , Rios-Carrasco Blanca , Gil Javier
Published: January 2023

The major problems for the osseointegration of dental implants are the loosening of the screw that fixes the dental implant to the abutment and the micromovements that are generated when mechanical loads are applied. In this work, torque differences in the tightening and loosening of the connection screws after 1 cycle, 10 cycles and 1000 cycles for 4 dental implants with 2 external and 2 internal connections were analyzed. The loosening of 240 implants (60 for each system) was determined using high-precision torsimeters and an electromechanical testing machine. A total of 60 dental implants for each of the 4 systems were inserted into fresh bovine bone to determine the micromovements. The implant stability values (ISQ) were determined by RFA. The mechanical loads were performed at 30° from 20 N to 200 N. By means of the Q-star technique, the micromovements were determined. It was observed that, for a few cycles, the loosening of the screw did not exceed a loss of tightening of 10% for both connections. However, for 1000 cycles, the loss for the external connection was around 20% and for the internal connection it was 13%. The micromovements showed a lineal increase with the applied load for the implant systems studied. An external connection presented greater micromotions for each level of applied load and lower ISQ values than internal ones. An excellent lineal correlation between the ISQ and micromobility was observed. These results may be very useful for clinicians in the selection of the type of dental implant, depending on the masticatory load of the patient as well as the consequences of the insertion torque of the dental implant and its revisions.
Impact of the 3% Oxygen Desaturation Index via Overnight Pulse Oximetry on Cardiovascular Events and Death in Patients Undergoing Hemodialysis: A Retrospective Cohort Study
Authors: Mochida Yasuhiro , Ohtake Takayasu , Ishioka Kunihiro , Oka Machiko , Maesato Kyoko , Moriya Hidekazu , Hidaka Sumi , Kobayashi Shuzo
Published: January 2023

It is unclear whether the severity of sleep-disordered breathing (SDB) affects the risk of cardiovascular events and mortality in patients undergoing hemodialysis (HD). We determined the severity of SDB with the 3% oxygen desaturation index (ODI) via overnight pulse oximetry. This study was a retrospective cohort, observational study of 134 patients on maintenance HD at a single center. They were divided into four groups according to SDB severity (normal, mild, moderate, and severe), and were followed. The baseline characteristics of all patients were as follows: the median age was 67 (interquartile range, 59–75) years, 64.2% were men, 37.3% were diabetic, and the median duration of HD was 69 (29–132) months. During follow-up, major adverse cardiovascular events (MACEs) occurred in 71 patients and deaths in 60 (including 32 cardiovascular deaths). Severe SDB was an independent risk factor for MACEs (hazard ratio [HR] = 4.66, 95% confidence interval [CI] = 1.87–11.61, p = 0.001) and all-cause death (HR = 5.74, 95% CI = 1.92–16.70, p = 0.001). Severe SDB had a statistically significant impact on the risk of MACEs and mortality in patients undergoing HD. The severity of the 3% ODI via overnight pulse oximetry may be a useful marker as a risk factor for cardiovascular outcomes and mortality in these patients.
Antitumor Immunity Exerted by Natural Killer and Natural Killer T Cells in the Liver
Authors: Nakashima Hiroyuki , Kinoshita Manabu
Published: January 2023

The liver plays crucial roles in systemic immunity and greatly contributes to the systemic defense mechanism. Antitumor immunity in the liver is especially critical for the defense against systemic tumor cell dissemination. To achieve effective defense against metastatic tumor cells, liver immune cells with powerful cytotoxic activities construct a potent defense mechanism. In the liver, as compared with other organs, there is a significantly more intense percentage of innate immune lymphocytes, such as natural killer (NK) and NKT cells. These characteristic lymphocytes survey the portal blood transferred to the liver from the alimentary tract and eliminate malignant cells with their robust cytotoxic ability. Additionally, with their active cytokine-producing capacity, these innate lymphocytes initiate immunological sequences by adaptive immune cells. Therefore, they are crucial contributors to systemic antitumor immunity. These attractive immune cells help conduct a fundamental investigation of tumor immunity and act as a target of clinical measures for cancer therapies. This review discusses the mechanisms of these innate lymphocytes regarding recognition and cytotoxicity against tumor cells and the possibility of clinical applications for therapeutic measures.
Locating the Mandibular Lingula Using Cone-Beam Computed Tomography: A Literature Review
Authors: Chen Chun-Ming , Lee Hui-Na , Chen Ying-Ting , Hsu Kun-Jung
Published: January 2023

This study aimed to review the literature on adult mandibular lingula (ML) locations and related distances determined using cone-beam computed tomography (CBCT). A search was conducted for studies on CBCT using the following databases: PubMed, Web of Science, and Embase. The search results were limited to studies published between 1970 and 2021. The inclusion criteria were the investigation of ML location, CBCT, and participants aged ≥18 years. Eligible studies were examined for the distances from the lingual tip to the anterior ramus border, posterior ramus border, sigmoid notch, inferior ramus border, and occlusal plane. Eight studies on CBCT qualified for inclusion in the study. The mean distances from the ML to the anterior ramus border were 15.57 to 20 mm. In most of these, the ML was located above the occlusal plane. No significant differences were observed in the location and related distances for the ML among patients of different sexes, ethnicities, or skeletal patterns.
Elective Tracheotomy in Patients Receiving Mandibular Reconstructions: Reduced Postoperative Ventilation Time and Lower Incidence of Hospital-Acquired Pneumonia
Authors: Schuderer Johannes G. , Reider Leonie , Wunschel Michael , Spanier Gerrit , Spoerl Steffen , Gottsauner Maximilian Josef , Maurer Michael , Meier Johannes K. , Kummer Peter , Reichert Torsten E. , Ettl Tobias
Published: January 2023

Elective tracheotomy (ET) secures the airway and prevents adverse airway-related events as unplanned secondary tracheotomy (UT), prolonged ventilation (PPV) or nosocomial infection. The primary objective of this study was to identify factors predisposing for airway complications after reconstructive lower ja surgery. We reviewed records of patients undergoing mandibulectomy and microvascular bone reconstruction (N = 123). Epidemiological factors, modus of tracheotomy regarding ET and UT, postoperative ventilation time and occurrence of hospital-acquired pneumonia HAP were recorded. Predictors for PPV and HAP, ET and UT were identified. A total of 82 (66.7%) patients underwent tracheotomy of which 12 (14.6%) were performed as UT. A total of 52 (42.3%) patients presented PPV, while 19 (15.4%) developed HAP. Increased operation time (OR 1.004, p = 0.005) and a difficult airway (OR 2.869, p = 0.02) were predictors, while ET reduced incidence of PPV (OR 0.054, p = 0.006). A difficult airway (OR 4.711, p = 0.03) and postoperative delirium (OR 6.761, p = 0.01) increased UT performance. HAP increased with anesthesia induction time (OR 1.268, p = 0.001) and length in ICU (OR 1.039, p = 0.009) while decreasing in ET group (HR 0.32, p = 0.02). OR for ET increased with mounting CCI (OR 1.462, p = 0.002) and preoperative radiotherapy (OR 2.8, p = 0.018). ET should be strongly considered in patients with increased CCI, preoperative radiotherapy and prolonged operation time. ET shortened postoperative ventilation time and reduced HAP.
Radial and Circumferential CMR-Based RV Strain Predicts Low R Wave Amplitude after ICD Implantation in Patients with Arrhythmogenic Cardiomyopathy
Authors: Chen Zhongli , Song Yanyan , Chen Liang , Ma Xuan , Dai Yan , Zhao Shihua , Chen Keping , Zhang Shu
Published: January 2023

Inadequate R wave amplitude (RWA) after implantable cardiac defibrillator (ICD) implantation in patients with arrhythmogenic cardiomyopathy (ACM) was suspected to relate to right ventricle impairment. However, little data-based evidence was provided to quantify the association. We retrospectively enrolled ACM patients receiving CMR examinations before transvenous ICD implantation from Fuwai Hospital. The RWA was obtained within 24 h and at 2–6-month follow-up after the operation. Structural, functional, as well as tissue characterization of the left ventricle (LV) and right ventricle (RV), were analyzed in relation to RWA. Among the 87 ACM patients (median RWA: 8.0 mV), 19 (21.8%) patients were found with low initial RWA (<5 mV) despite attempts in multiple positions. RV end diastolic diameter (RVEDD), (r = −0.44), RV ejection fraction (RVEF, r = 0.43), RV end diastolic volume index (RVEDVi, r = −0.49), RV end systolic volume index (RVESVi, r = −0.53), RV global circumferential (RVGCS, r = −0.64), and radial strain (RVGRS, r = 0.61, all p < 0.001) rather than LV metrics correlated strongly with initial RWA. RVGCS, RVESVi, and RVGRS were decent predictors of low RWA (areas under the curve AUC: 0.814, 0.769, 0.757, respectively) early after implantation and during 2–6-month follow-up. To summarize, low RWA of ICD lead in ACM patients was associated with RV abnormalities. The RVGCS, RVGRS, and RVESVi can be valuable predictors for identifying low RWA prior to ICD implantation.
Prospective Placebo-Controlled Assessment of Spore-Based Probiotic Supplementation on Sebum Production, Skin Barrier Function, and Acne
Authors: Rybak Iryna , Haas Kelly , Dhaliwal Simran , Burney Waqas , Pourang Aunna , Sandhu Simran , Maloh Jessica , Newman John , Crawford Robert , Sivamani Raja
Published: January 2023

Probiotic supplementation has been shown to modulate the gut–skin axis. The goal of this study was to investigate whether oral spore-based probiotic ingestion modulates the gut microbiome, plasma short-chain fatty acids (SCFAs), and skin biophysical properties. This was a single-blinded, 8-week study (NCT03605108) in which 25 participants, 7 with noncystic acne, were assigned to take placebo capsules for the first 4 weeks, followed by 4 weeks of probiotic supplementation. Blood and stool collection, facial photography, sebum production, transepidermal water loss (TEWL), skin hydration measurements, and acne assessments were performed at baseline, 4, and 8 weeks. Probiotic supplementation resulted in a decreasing trend for the facial sebum excretion rate and increased TEWL overall. Subanalysis of the participants with acne showed improvement in total, noninflammatory, and inflammatory lesion counts, along with improvements in markers of gut permeability. The gut microbiome of the nonacne population had an increase in the relative abundance of Akkermansia, while the subpopulation of those with acne had an increase in the relative abundance of Lachnospiraceae and Ruminococcus gnavus. Probiotic supplementation augmented the circulating acetate/propionate ratio. There is preliminary evidence for the use of spore-based probiotic supplementation to shift the gut microbiome and augment short-chain fatty acids in those with and without acne. Further spore-based supplementation studies in those with noncystic acne are warranted.
Suprapapillary Biliary Stents Have Longer Patency Times than Transpapillary Stents—A Systematic Review and Meta-Analysis
Authors: Kovács Norbert , Pécsi Dániel , Sipos Zoltán , Farkas Nelli , Földi Mária , Hegyi Péter , Bajor Judit , Erőss Bálint , Márta Katalin , Mikó Alexandra , Rakonczay Zoltán , Sarlós Patrícia , Ábrahám Szabolcs , Vincze Áron
Published: January 2023

Background and study aims: Endoscopic biliary stent placement is a minimally invasive intervention for patients with biliary strictures. Stent patency and function time are crucial factors. Suprapapillary versus transpapillary stent positioning may contribute to stent function time, so a meta-analysis was performed in this comparison. Methods: A comprehensive literature search was conducted in the CENTRAL, Embase, and MEDLINE databases to find data on suprapapillary stent placement compared to the transpapillary method via endoscopic retrograde cholangiopancreatography in cases of biliary stenosis of any etiology and any stent type until December 2020. We carried out a meta-analysis focusing on the following outcomes: stent patency, stent migration, rate of cholangitis and pancreatitis, and other reported complications. Results: Three prospective and ten retrospective studies involving 1028 patients were included. Suprapapillary stent placement appeared to be superior to transpapillary stent positioning in patency (weighted mean difference = 50.23 days, 95% CI: 8.56, 91.98; p = 0.0.018). In a subgroup analysis of malignant indications, suprapapillary positioning showed a lower rate of cholangitis (OR: 0.34, 95% CI: 0.13, 0.93; p = 0.036). Another subgroup analysis investigating metal stents in a suprapapillary position resulted in a lower rate of pancreatitis (OR: 0.16, 95% CI: 0.03, 0.95; p = 0.043) compared to transpapillary stent placement. There was no difference in stent migration rates between the two groups (OR: 0.67, 95% CI: 0.17, 2.72; p = 0.577). Conclusions: Based on our results, suprapapillary biliary stenting has longer stent patency. Moreover, the stent migration rate did not differ between the suprapapillary and transpapillary groups.
Bacterial Cellulose/Cellulose Imidazolium Bio-Hybrid Membranes for In Vitro and Antimicrobial Applications
Authors: Salama Ahmed , Saleh Ahmed K. , Cruz-Maya Iriczalli , Guarino Vincenzo
Published: January 2023

In biomedical applications, bacterial cellulose (BC) is widely used because of its cytocompatibility, high mechanical properties, and ultrafine nanofibrillar structure. However, biomedical use of neat BC is often limited due to its lack of antimicrobial properties. In the current article, we proposed a novel technique for preparing cationic BC hydrogel through in situ incorporation of cationic water-soluble cellulose derivative, cellulose bearing imidazolium tosylate function group (Cell-IMD), in the media used for BC preparation. Different concentrations of cationic cellulose derivative (2, 4, and 6%) were embedded into a highly inter-twined BC nanofibrillar network through the in situ biosynthesis until forming cationic cellulose gels. Cationic functionalization was deeply examined by the Fourier transform infrared (FT–IR), NMR spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) methods. In vitro studies with L929 cells confirmed a good cytocompatibility of BC/cationic cellulose derivatives, and a significant increase in cell proliferation after 7 days, in the case of BC/Cell-IMD3 groups. Finally, antimicrobial assessment against Staphylococcus aureus, Streptococcus mutans, and Candida albicans was assessed, recording a good sensitivity in the case of the higher concentration of the cationic cellulose derivative. All the results suggest a promising use of cationic hybrid materials for biomedical and bio-sustainable applications (i.e., food packaging).
The Influence of Saliva pH on the Fracture Resistance of Two Types of Implant-Supported Bis-Acrylic Resin Provisional Crowns—An In Vitro Study
Authors: Sousa-Santos Sofia , Silva António Sérgio , Sousa-Santos Primavera , Vale Teresa , Mendes José Manuel
Published: January 2023

Temporary restorations play a fundamental role in oral rehabilitation. A properly adapted implant-supported provisional restoration implies better esthetics, contouring and architectural modeling of the upper peri-implant tissue. This study aimed to evaluate the influence of oral pH on the fracture resistance of implant-supported provisional restorations made with two brands of bis-acrylic resin (LuxaCrown® and Protemp™ 4) and to compare the fracture resistance of these two materials. Twenty crowns (ten manufactured using each brand) served as a control, and another forty crowns (twenty of each brand) were aged using artificial saliva with pHs of 4 or 7, for 7 days at 37 °C, in an attempt to simulate the behavior of these materials inside the oral cavity. Subsequently, all crowns were subjected to the application of a force at a constant speed, in a universal testing machine, until fracture was achieved. The LuxaCrown® brand showed greater resistance to fracture than the Protemp™ 4 brand. Salivary pH did not influence the fracture resistance of provisional LuxaCrown® crowns but did influence the fracture resistance of provisional Protemp™ 4 crowns.
Fear of Missing Out, Emotional Intelligence and Attachment in Older Adults in Argentina
Authors: Durao Marian , Etchezahar Edgardo , Albalá Genol Miguel Ángel , Muller Mariela
Published: January 2023

In recent years, the rise of social networks has changed relationships and lifestyles around the world. This has led to the emergence of the Fear of Missing Out (FoMO), which consists of the need to constantly check social media and the anguish that comes from feeling a lack of rewarding experiences. The impact derived from the use of technologies in a digital environment has been widely studied in young people but not so much in older adults. The main aim of this study was to analyze FoMO levels in older adults and their relationships with sociodemographic and formative factors. Another aim of this study was to analyze whether the dimensions of emotional intelligence, the different forms of attachment and psychological symptomatology affect the FoMO levels of older adults. A total of 690 older adults from Argentina aged between 60 and 90 years (M = 69.01; SD = 5.48) participated, 54.5% of whom were women, responding using a geolocated online questionnaire. The main results confirmed that older people show FoMO levels similar to other general samples. In addition, results show several predictor variables with respect to FoMO: emotional attention, insecure attachment, depression and difficulties in interpersonal relationships. The implications of the results observed in older adults are discussed.
Study of Nitrogen-Doped Carbon Nanotubes for Creation of Piezoelectric Nanogenerator
Authors: Il’ina Marina V. , Soboleva Olga I. , Khubezov Soslan A. , Smirnov Vladimir A. , Il’in Oleg I.
Published: January 2023

The creation of sustainable power sources for wearable electronics and self-powered systems is a promising direction of modern electronics. At the moment, a search for functional materials with high values of piezoelectric coefficient and elasticity, as well as non-toxicity, is underway to generate such power sources. In this paper, nitrogen-doped carbon nanotubes (N-CNTs) are considered as a functional material for a piezoelectric nanogenerator capable of converting nanoscale deformations into electrical energy. The effect of defectiveness and of geometric and mechanical parameters of N-CNTs on the current generated during their deformation is studied. It was established that the piezoelectric response of N-CNTs increased nonlinearly with an increase in the Young’s modulus and the aspect ratio of the length to diameter of the nanotube and, on the contrary, decreased with an increase in defectiveness not caused by the incorporation of nitrogen atoms. The advantages of using N-CNT to create energy-efficient piezoelectric nanogenerators are shown.
Survival Factor A (SvfA) Contributes to Aspergillus nidulans Pathogenicity
Authors: Lim Joo-Yeon , Jung Ye-Eun , Hwang Hye-Eun , Kim Cheol-Hee , Basaran-Akgul Nese , Goli Sri Harshini , Templeton Steven P. , Park Hee-Moon
Published: January 2023

Survival factor A (SvfA) in Aspergillus nidulans plays multiple roles in growth and developmental processes. It is a candidate for a novel VeA-dependent protein involved in sexual development. VeA is a key developmental regulator in Aspergillus species that can interact with other velvet-family proteins and enter into the nucleus to function as a transcription factor. In yeast and fungi, SvfA-homologous proteins are required for survival under oxidative and cold-stress conditions. To assess the role of SvfA in virulence in A. nidulans, cell wall components, biofilm formation, and protease activity were evaluated in a svfA-gene-deletion or an AfsvfA-overexpressing strain. The svfA-deletion strain showed decreased production of β-1,3-glucan in conidia, a cell wall pathogen-associated molecular pattern, with a decrease in gene expression for chitin synthases and β-1,3-glucan synthase. The ability to form biofilms and produce proteases was reduced in the svfA-deletion strain. We hypothesized that the svfA-deletion strain was less virulent than the wild-type strain; therefore, we performed in vitro phagocytosis assays using alveolar macrophages and analyzed in vivo survival using two vertebrate animal models. While phagocytosis was reduced in mouse alveolar macrophages challenged with conidia from the svfA-deletion strain, the killing rate showed a significant increase with increased extracellular signal-regulated kinase ERK activation. The svfA-deletion conidia infection reduced host mortality in both T-cell-deficient zebrafish and chronic granulomatous disease mouse models. Taken together, these results indicate that SvfA plays a significant role in the pathogenicity of A. nidulans.
Systemic Antifungal Therapy for Invasive Pulmonary Infections
Authors: Ben-Ami Ronen
Published: January 2023

Antifungal therapy for pulmonary fungal diseases is in a state of flux. Amphotericin B, the time-honored standard of care for many years, has been replaced by agents demonstrating superior efficacy and safety, including extended-spectrum triazoles and liposomal amphotericin B. Voriconazole, which became the treatment of choice for most pulmonary mold diseases, has been compared with posaconazole and itraconazole, both of which have shown clinical efficacy similar to that of voriconazole, with fewer adverse events. With the worldwide expansion of azole-resistant Aspergillus fumigatus and infections with intrinsically resistant non-Aspergillus molds, the need for newer antifungals with novel mechanisms of action becomes ever more pressing.
The Association between Electronegative Low-Density Lipoprotein Cholesterol L5 and Cognitive Functions in Patients with Mild Cognitive Impairment
Authors: Chou Ping-Song , Chen Sharon Chia-Ju , Hsu Chung-Yao , Liou Li-Min , Juan Chi-Hung , Lai Chiou-Lian
Published: January 2023

L5, the most electronegative subfraction of low-density lipoprotein cholesterol (LDL-C), may play a role in the pathogenesis of cerebrovascular dysfunction and neurodegeneration. We hypothesized that serum L5 is associated with cognitive impairment and investigated the association between serum L5 levels and cognitive performance in patients with mild cognitive impairment (MCI). This cross-sectional study conducted in Taiwan included 22 patients with MCI and 40 older people with normal cognition (healthy controls). All participants were assessed with the Cognitive Abilities Screening Instrument (CASI) and a CASI-estimated Mini-Mental State Examination (MMSE-CE). We compared the serum total cholesterol (TC), LDL-C, and L5 levels between the MCI and control groups and examined the association between lipid profiles and cognitive performance in these groups. The serum L5 concentration and total CASI scores were significantly negatively correlated in the MCI group. Serum L5% was negatively correlated with MMSE-CE and total CASI scores, particularly in the orientation and language subdomains. No significant correlation between the serum L5 level and cognitive performance was noted in the control group. Conclusions: Serum L5, instead of TC or total LDL-C, could be associated with cognitive impairment through a disease stage-dependent mode that occurs during neurodegeneration.
Learning Curve of Robotic Lobectomy for the Treatment of Lung Cancer: How Does It Impact on the Autonomic Nervous System of the Surgeon?
Authors: Mazzella Antonio , Mohamed Shehab , Maisonneuve Patrick , Sedda Giulia , Cara Andrea , Casiraghi Monica , Petrella Francesco , Donghi Stefano Maria , Lo Iacono Giorgio , Spaggiari Lorenzo
Published: January 2023

Objective: Our purpose is to define the learning curve for robot-assisted thoracoscopic surgery lobectomy by reporting the experience of a single surgeon. Material and methods: We progressively collected the data concerning the surgical performance of a single male thoracic surgeon, from the beginning of his robotic activity as first operator from January 2021 to June 2022. We evaluated several pre-, intra- and postoperative parameters concerning patients and intraoperative cardiovascular and respiratory outcomes of the surgeon, recorded during surgical interventions, in order to evaluate his cardiovascular stress. We used cumulative sum control charts (CUSUM) to analyze the learning curve. Results: A total of 72 lung lobectomies were performed by a single surgeon in this period. Analyzing the CUSUM of several parameters, the inflection point identifying the transition beyond the surgeon learning phase was reached at cases 28, 22, 27 and 33 when considering operating time, mean heart rate, max heart rate and mean respiratory rate, respectively. Conclusions: The learning curve for robotic lobectomy seems to be safe and feasible with a correct robotic training program. The analysis of a single surgeon from the beginning of his robotic activity demonstrates that confidence, competence, dexterity and security are achieved after about 20–30 procedures, without compromising efficiency and oncological radicality.
Use of Telemedicine Healthcare Systems in Pediatric Assistance at Territorial Level: Consensus Document of the Italian Society of Telemedicine (SIT), of the Italian Society of Preventive and Social Pediatrics (SIPPS), of the Italian Society of Pediatric Primary Care (SICuPP), of the Italian Federation of Pediatric Doctors (FIMP) and of the Syndicate of Family Pediatrician Doctors (SIMPeF)
Authors: Esposito Susanna , Rosafio Cristiano , Antodaro Francesco , Argentiero Alberto , Bassi Marta , Becherucci Paolo , Bonsanto Fabio , Cagliero Andrea , Cannata Giulia , Capello Fabio , Cardinale Fabio , Chiriaco Tiziana , Consolaro Alessandro , Dessì Angelica , Di Mauro Giuseppe , Fainardi Valentina , Fanos Vassilios , Guarino Alfredo , Li Calzi Giada , Lodi Elisa , Maghnie Mohamad , Manfredini Luca , Malorgio Emanuela , Minuto Nicola , Modena Maria Grazia , Montori Rossano , Moscatelli Andrea , Patrone Elisa , Pescio Elena , Poeta Marco , Ravelli Angelo , Spelta Maddalena , Suppiej Agnese , Vai Sergio , Villa Luca , Zanini Rinaldo , Botti Renato , Gaddi Antonio Vittorino
Published: January 2023

Technological innovation can contribute to a reorganization of healthcare, particularly by supporting the shift in the focus of care from the hospital to the territory, through innovative citizen-centered models, and facilitating access to services in the territory. Health and social care delivery modalities, enabled by telemedicine, are crucial in this regard. The objective of this Consensus document, written by the main Italian Scientific Societies involved in the use of telemedicine in pediatrics, is to define a standard for its use at the territorial level in various declinations in the pediatric field; this paper also identifies priority areas for its application and the types of services that most require intervention and investment. The changes that are underway in digital transformation in all sectors are unstoppable, and for the digital transformation to take place in a productive sense, the contribution of not only all health professionals, but also of patients, is necessary. From this perspective, authors from different backgrounds were involved in the drafting of this Consensus and, in the future, other figures, primarily patients, are expected to be involved. In fact, this belongs to the vision of connected care, in which the citizen/patient actively participates in the treatment path so that they are assisted in a personalized, predictive and preventive way. The future scenario must be able to provide for the involvement of patients from the initial stages of planning any treatment path, even in the pediatric age, and increasing, where possible, the proximity of the health service to the families.
Sociogeomorphological Analysis in a Headwater Basin in Southern Brazil with Emphasis on Land Use and Land Cover Change
Authors: González-Ávila Itzayana , Jato-Espino Daniel , Paixão Mauricio Andrades , Carvalho Michele Moraes , Kobiyama Masato
Published: January 2023

Effects of natural processes on community building and the modification of nature by man’s hands are an intrinsic part of the co-production of the landscape between man and nature. However, the interactions of this co-production have scarcely been analyzed. Based on data from the MapBiomas project, an analysis of the variation in land use and cover over 35 years in the Quilombola São Roque and Mãe dos Homens communities in southern Brazil was carried out. The sociogeomorphological units in the study area were established, and its geomorphological units and social units were analyzed and described. There is a prevalence of more than 50% of forest formation. Cluster analysis classified the analyzed variables into two groups, with the first corresponding to forest and grassland formations associated with more natural landscape features. The second group is formed by anthropogenic activities. Social units including traditional communities seem to be more related to the stimulation of forest formation. The action of conservation units influences the variation in land use and land cover. There is a Supplementary Material which explains abbreviations concerning the manuscript.
Mapping and Monitoring Spatio-Temporal Patterns of Rainfed Agriculture Lands of North Darfur State, Sudan, Using Earth Observation Data
Authors: Altoom Mohammed B. , Adam Elhadi , Ali Khalid Adem
Published: January 2023

Rainfed agriculture in Northern Darfur is influenced by erratic seasonal and decadal rainfall patterns and frequent droughts. Understanding the spatio-temporal variation in rainfed agriculture is crucial for promoting food security, socio-economic stability and protecting the vulnerable ecosystem. This study aimed to investigate the spatio-temporal dynamics of rainfed agriculture in North Darfur State from 1984–2019 using multitemporal Landsat observation data. Using the random forest technique, the multitemporal images were classified into common land use/land cover classes and rainfed agriculture on goz (sandy) and wadi (seasonal river) lands. Overall accuracies were assessed using a confusion matrix. Overall accuracies were assessed using a confusion matrix has ranging between 94.7% and 96.9%, while the kappa statistics were greater than 0.90. The results showed that the high spatial variability in goz land used for rainfed agriculture increased of (889,622.46 ha) over 1994–1999, while it decreased (658,568.61 ha) over 2004–2009 south of the 232.9 mm isohyet. Rainfed cultivation of wadi lands expanded significantly of (580,515.03 ha) over 2014–2019 and decreased (182,701.8 ha) over 1994–1999, especially in the 362.8–477.2 mm isohyets (beyond the climate-adapted 500 mm isohyet agronomic dry limit). These spatial trends need further investigation as they may exacerbate both regional land degradation and disputes among farmers over scarce wadi lands. This study provides essential spatial data which are lacking owing to ongoing conflicts; this can help decision-makers formulate sustainable land use monitoring systems.
Construction of Water Corridors for Mitigation of Urban Heat Island Effect
Authors: Lin Jiqing , Yang Wufa , Yu Kunyong , Geng Jianwei , Liu Jian
Published: January 2023

The urban heat island (UHI) effect is becoming increasingly prominent owing to accelerated urbanization in Fuzhou, affecting the lives of people. Water is an important landscape element that can effectively improve the urban thermal environment. The construction of water corridors has been proven to mitigate the intensity of the UHI effect in Fuzhou. Therefore, we obtained the distribution of a water system in Fuzhou from image data and analyzed temperature watersheds using the inversion of surface temperature to investigate the inner mechanism of the water system influencing the UHI effect. The water system was superimposed with hot spots to obtain cooling ecological nodes and construct water corridors to mitigate the UHI effect. The temperature watershed areas in Fuzhou are: Minhou County (353.77 km2), Changle (233.06 km2), Mawei (137.82 km2), Cangshan (71.25 km2), Jin’an (55.99 km2), Gulou (16.93 km2), and Taijiang (15.51 km2) Districts. Hot spots were primarily located in Changle, Cangshan, Jin’an, Gulou, and Taijiang Districts. The superposition of the water system and temperature watershed yielded 152 cooling ecological nodes, which were concentrated in the Minjiang and Wulong River watershed, with no cooling ecological nodes distributed within the central city. Twenty-five cooling ecological nodes were selected in the hot spot areas, which were primarily distributed in reservoirs, inland rivers, and park water systems. We constructed 12 water corridors, including four, three, two, one, one, and one in the Minhou County, Changle, Mawei, Jin’an, Cangshan, and the Gulou and Taijiang Districts.
Effect of Agricultural Structure Adjustment on Spatio-Temporal Patterns of Net Anthropogenic Nitrogen Inputs in the Pearl River Basin from 1990 to 2019
Authors: Xu Kai , Zhou Jiaogen , Lei Qiuliang , Wu Wenbiao , Mao Guangxiong
Published: January 2023

Worldwide urbanization has brought dramatic changes in agricultural structures, as well as serious agricultural non-point source pollutions of nitrogen and phosphorus. However, understanding the effect of agricultural structure adjustment on net anthropogenic nitrogen inputs (NANI) has been still limited. In this paper, statistical data from the agricultural statistical Yearbook, the National Economic and Social Development Statistical Bulletin were collected from 1990 to 2019 in the Pearl River Basin, China, and used to analyze the spatial and temporal patterns of NANI and its influencing factors. The results indicated that the agricultural structure adjustment has significantly influenced the spatial and temporal patterns of NANI in the last 30 years in the Pearl River Basin. The NANI decreased from 1990 to 2019, and had a spatial pattern of higher values in the upstream areas and lower in the downstream areas. In terms of the nitrogen input sources of NANI, in the economically developed regions downstream, nitrogen inputs are dominated by food/feed nitrogen, which accounted for an average of 49.6% of total nitrogen inputs. In upstream areas with relatively low economic development, fertilizer nitrogen accounted for an average of 54.9% of total nitrogen inputs. A novel nitrogen input source index of NANI, namely the ratio of agricultural nitrogen inputs to non-agricultural nitrogen inputs of NANI(ASNA), was also proposed to characterize the impact of the agricultural industry restructuring on NANI changes over time. Similar to the characteristics of NANI from 1990 to 2019, the ASNA showed a decreasing trend in the study area. Moreover, agricultural variables (agricultural land area, nitrogen fertilizer consumption and livestock farming density) tended to contribute less to the explained ASNA variances, while the contributions of the non-agricultural factors (population density and non-agricultural GDP) increased from 1990 to 2019. This indicated that the contribution of nitrogen inputs from agricultural sources to the NANI decreased while the contribution of nitrogen inputs from non-agricultural sources increased, with the shifts of agricultural sectors to the secondary and tertiary sectors in the Pearl River Basin. Our findings also suggest that differently regional targeting should be considered for the nitrogen pollution management in the Pearl River Basin, which focuses on the nitrogen pollution management of non-agricultural sources in the downstream areas, and but highlights agricultural nitrogen pollution management in the upstream areas.
Addressing Peripherality in Italy: A Critical Comparison between Inner Areas and Territorial Capital-Based Evaluations
Authors: Blečić Ivan , Cecchini Arnaldo , Muroni Emanuel , Saiu Valeria , Scanu Serafino , Trunfio Giuseppe Andrea
Published: January 2023

As highlighted by the UN 2030 Agenda, sustainable development is a complex and multidimensional issue that can be effectively implemented and reached at the local level. This implies the evaluation of differences and disparities between territories in order to define local priorities and support cohesion policy objectives. This need has been addressed by the Italian “National Strategy for Inner Areas”, which aims to support the growth of territories with a continuous economic and population decline. However, Inner Areas are identified by a set of indicators related to the low accessibility to Services of General Interest, neglecting other important factors that contribute to this condition. This paper proposes a critical analysis of this measurement and of the related “territorialization” of Inner Areas, by introducing a more comprehensive assessment model based on the concept of Territorial Capital (TC), which highlights a more nuanced understanding of complexities and diversities related to the potential development of a territory. In particular, the proposed model evaluates eight TC dimensions (human, social, cognitive, infrastructural, productive, relational, environmental and settlement capital), which cover a broad spectrum of Sustainable Development Goals (SDGs). In order to accurately demonstrate the differences between the results of the two evaluation methods, this paper presents the results of a case study application concerning all 377 municipalities, which compose the Autonomous Region of Sardinia (Italy). The findings of this study confirm the potential of an approach based on the Territorial Capital for place-based policymaking. TC, in fact, can become relevant for defining local priorities and supporting complex decisions, allowing governments to better design and tailor interventions for the effective and efficient management of available resources. Furthermore, these results pose new questions for future research developments in the field of sustainable and equitable development.
Measuring and Decomposing Relative Poverty in China
Authors: Zou Wei , Cheng Xiaopei , Fan Zengzeng , Lin Chuhao
Published: January 2023

Poverty is a critical issue in sustainable development, and the study of poverty has gradually shifted from absolute to relative poverty. This paper measures three types of relative poverty—strongly relative poverty (50% of median income), strongly relative poverty (50% of mean income), and weakly relative poverty. Then this paper decomposes the change of relative poverty into the growth component, redistribution component, and poverty line change component. Further, the intra- and inter-group decompositions of relative poverty change are carried out by considering the urban and rural population mobility components. We apply the China Health and Nutrition Survey (CHNS) data from 1989 to 2015 for an empirical study. The results show that: (1) In recent years, the change in relative poverty in China has shown a trend of low fluctuation (1989–1997), rising fluctuation (1997–2006), and high fluctuation (2006–2015). (2) In the decomposition of relative poverty change, the growth component has the most excellent effect on alleviating relative poverty, the redistribution component exacerbates the occurrence of relative poverty in most years and reduces it in a few years, and the poverty line change component offsets the poverty reduction effect of the growth component. (3) The change in relative poverty is decomposed by urban and rural sub-groups, and it is found that the population mobility from rural to urban can reduce the national relative poverty.
Comparison of the Results of Cardiopulmonary Exercise Testing between Healthy Peers and Pediatric Patients with Different Echocardiographic Severity of Mitral Valve Prolapse
Authors: Huang Ming-Hsuan , Tuan Sheng-Hui , Tsai Yun-Jeng , Huang Wei-Chun , Huang Ta-Cheng , Chang Shin-Tsu , Lin Ko-Long
Published: January 2023

Patients with mitral valve prolapse (MVP) have been reported to have exercise intolerance. However, the underlying pathophysiological mechanisms and their physical fitness remain unclear. We aimed to determine the exercise capacity of patients with MVP through the cardiopulmonary exercise test (CPET). We retrospectively collected the data of 45 patients with a diagnosis of MVP. Their CPET and echocardiogram results were compared with 76 healthy individuals as primary outcomes. No significant differences regarding the patient’s baseline characteristics and echocardiographic data were found between the two groups, except for the lower body mass index (BMI) of the MVP group. Patients in the MVP group demonstrated a similar peak metabolic equivalent (MET), but a significantly lower peak rate pressure product (PRPP) (p = 0.048). Patients with MVP possessed similar exercise capacity to healthy individuals. The reduced PRPP may indicate compromised coronary perfusion and subtle left ventricular function impairment.
Quasi-Movements and “Quasi-Quasi-Movements”: Does Residual Muscle Activation Matter?
Authors: Vasilyev Anatoly N. , Yashin Artem S. , Shishkin Sergei L.
Published: January 2023

Quasi-movements (QM) are observed when an individual minimizes a movement to an extent that no related muscle activation is detected. Likewise to imaginary movements (IM) and overt movements, QMs are accompanied by the event-related desynchronization (ERD) of EEG sensorimotor rhythms. Stronger ERD was observed under QMs compared to IMs in some studies. However, the difference could be caused by the remaining muscle activation in QMs that could escape detection. Here, we re-examined the relation between the electromyography (EMG) signal and ERD in QM using sensitive data analysis procedures. More trials with signs of muscle activation were observed in QMs compared with a visual task and IMs. However, the rate of such trials was not correlated with subjective estimates of actual movement. Contralateral ERD did not depend on the EMG but still was stronger in QMs compared with IMs. These results suggest that brain mechanisms are common for QMs in the strict sense and “quasi-quasi-movements” (attempts to perform the same task accompanied by detectable EMG elevation) but differ between them and IMs. QMs could be helpful in research aimed at better understanding motor action and at modeling the use of attempted movements in the brain-computer interfaces with healthy participants.
Technical Performance and Chemical–Physical Property Assessment of Safflower Oil Tested in an Experimental Hydraulic Test Rig
Authors: Ugolini Luisa , Matteo Roberto , Lazzeri Luca , Malaguti Lorena , Folegatti Liliana , Bondioli Paolo , Pochi Daniele , Grilli Renato , Fornaciari Laura , Benigni Stefano , Fanigliulo Roberto
Published: January 2023

Safflower (Carthamus tinctorius L.) is an underestimated and multipurpose crop resistant to environmental stresses. Its oil presents useful chemical–physical properties, potentially exploitable for industrial purposes as a bio-based lubricant. In this work safflower oil was applied as a less toxic alternative to mineral-based hydraulic fluids. The extracted oil was partially refined and the antioxidant tert-buthylhydroquinone (THBQ) was added at two concentrations (0.25 and 3.00 mg kg−1). Efficiency tests of the obtained oil were carried out using an experimental test rig capable of simulating a real hydraulic system and performing severe short-duration work cycles with the aim of strongly accelerating the ageing of the tested oil. Oil performance was verified by monitoring hydraulic and chemical–physical parameters, which were correlated to the main lubricant properties through sensor detection and laboratory analysis in parallel. The results indicated that the safflower oil behaved well at both THBQ concentrations and showed good technical performance (operating pressure and temperature; flowrate and transmitted hydraulic power), though a higher THBQ concentration was necessary to protect the oil’s chemical–physical properties from worsening. In fact, the higher THBQ concentration allowed the test to be extended to 270 h, an improvement compared to the 150 h that was achieved with the lower THBQ concentration. Finally, the use of safflower oil for industrial and agricultural purposes seems feasible and would contribute toward the sustainability of the whole crop rotation in a prospective valuable circular economy.
Corrosion and Mechanical Behavior of Metal Materials
Authors: Liu Ming
Published: January 2023

Many high-strength metal-related materials and structures work under the coupling condition of harsh corrosion environments and complex loading [...]
Dynamic Recrystallization Behaviours in Metals and Alloys
Authors: Montheillet Frank
Published: January 2023

The existence of dynamic recrystallization (DRX), i [...]
Influence of Aging Temperature on Mechanical Properties and Structure of M300 Maraging Steel Produced by Selective Laser Melting
Authors: Kolomy Stepan , Sedlak Josef , Zouhar Jan , Slany Martin , Benc Marek , Dobrocky David , Barenyi Igor , Majerik Jozef
Published: January 2023

This paper deals with the study of high-strength M300 maraging steel produced using the selective laser melting method. Heat treatment consists of solution annealing and subsequent aging; the influence of the selected aging temperatures on the final mechanical properties—microhardness and compressive yield strength—and the structure of the maraging steel are described in detail. The microstructure of the samples is examined using optical and electron microscopy. The compressive test results show that the compressive yield strength increased after heat treatment up to a treatment temperature of 480 °C and then gradually decreased. The sample aged at 480 °C also exhibited the highest observed microhardness of 562 HV. The structure of this sample changed from the original melt pools to a relatively fine-grained structure with a high fraction of high-angle grain boundaries (72%).
Alumino-Silicate Structural Formation during Alkali-Activation of Metakaolin: In-Situ and Ex-Situ ATR-FTIR Studies
Authors: Onutai Sujitra , Osugi Takeshi , Sone Tomoyuki
Published: January 2023

Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy was used to demonstrate the reaction mechanisms of alkali-activated materials (AAMs) and the early stage of structure formation in the materials. The effects of different types of alkali activator solutions on the structure formation and reaction mechanisms of AAMs were studied. The results revealed that the main peaks of the ATR-FTIR spectra of the AAMs in the 1300–650 cm−1 range shifted to a low wavenumber with changing patterns, depending on the activator solution used, indicating that the dissolution and reorientation of metakaolin had occurred. Silica and alumina monomers were dissolved by the NaOH solution to produce crystalline zeolites. Although the reaction between metakaolin and Na2SiO3 solution is slow, the condensation between the Al-OH from metakaolin and the Si-OH from Na2SiO3 solution bonded the chain to be longer. Therefore, the Na2SiO3 solution acted as a template-bonded monomer, formed long chains of Si–O–Si and Si–O–Al, and produced an amorphous AAM structure. In the mixed solution, when the NaOH in it dissolved the Si and Al monomers, the Na2SiO3 in the solution also bonded with monomers and produced a complex structure. The different reaction that metakaolin had with different alkali activator solutions reflected the different phases, microstructures, and mechanical properties of the AAMs produced.