bluuebunny/crossref_metadata_2025 huggingface dataset:
Point Of Sales (POS) Application On Clients of PT. Esensi Solusi Buana
Authors: Wulandari Ria , Maesaroh Siti , Erwansyah Erwansyah
Published: April 2021

Point of Sales application is a system used for transaction data into the database both by input and output, so that there are no errors in input, output data, and report generation based on the corresponding data, thus it can produce accurate output data. PT Esensi Solusi Buana is a company engaged in the field of technology and information. Based on surveys and interviews with clients of PT Esensi Solusi Buana, it is obtained the information about the operating system that is still manual and less than optimal.This causes frequent errors in recording sales transaction data, archiving that still uses the traditional system, as well as access to obtain information about the transaction history that requires a lot of time. Therefore, the system to be made is an improvement of the system that was previously made for the clients of PT Esensi Solusi Buana. It is expected that with this system, it can minimize errors that may occur. This system is also expected to be able to improve the process of input, output, and report generation, which in turn can help data collection of sales transactions on the clients of PT Esensi Solusi Buana
Teori Oligarki Winters Atas Penambangan Batubara Di Kalimantan Timur
Authors: Febriani Anita , Istanti Dilla Janu , Wibowo Ponco
Published: April 2021

Oligarchy portrait occurs in the process of coal mining in East Kalimantan. Many of the power-holding elites are involved in collaborating to become a mining resource chain in East Kalimantan. The Sexi Killer film by WatchDoc Documentary provides a clear picture of how the elite was involved in becoming coal mining players in East Kalimantan. Coal mining does not necessarily bring prosperity to the surrounding community but instead brings about various environmental disasters. Several names of the ruling elite were dragged into the circle of mining business practices. Jefri A. Winters' oligarchic theory can explain why this portrait can occur. Through authority, the elites control material resources to increase wealth and maintain their social position. Democracy seems to have slipped into an oligarchic circle. The elites control material resources to increase wealth and maintain their social position. The oligarchy seen in the Soeharto era did not just disappear. Oligarchy develops in a different form. The oligarchy during the Soeharto era was a sultanic oligarchy, now it has transformed into an oligarchy of collective rulers.
DESAIN MAJALAH GUNA MEDIA PENUNJANG INFORMASI PADA PT PRAMESTA BAJA UTAMA
Authors: Kusuma Vina Vijaya , Sanni M. Ifran , Maulana. S Rifqi Irfan
Published: April 2021

Setiap perusahaan pada umumnya, baik perusahaan swasta maupun pemerintah mengharapkan dapat menciptakan media promosi yang bagus dan dapat di lihat oleh masyarakat luas. Mengingat pentingnya media promosi PT. Pramesta Baja Utama membuat desain majalah yang hasilnya nanti akan di berikan kepada calon customer, agar calon customer tertarik dengan produk yang ada di PT. Pramesta Baja Utama. Adapun metode yang di gunakan untuk membuat majalah tersebut menggunakan aplikasi photoshop CS6.
PENINGKATAN PROMOSI MELALUI VIDEO IKLAN PADA SMA PLUS ISLAMIC VILLAGE KABUPATEN TANGERANG
Authors: Desrianti Dewi Immaniar , Supriati Ruli , Permatasari Mia
Published: April 2021

Dunia Pendidikan memiliki perkembangan yang pesat, dilihat dari semakin banyaknya sekolah – sekolah yang membuat serta mengembangkan media promosi agar instasi tersebut dapat dikenal oleh masyarakat luas. Salah satu media promosi yang dirasa cukup berkembang dan dirasa efektif di zaman modern ini ialah media video iklan. Maka dari itu, permasalahan yang dihadapi saat ini penyajian media informasi dan promosinya saat hanya menggunakan media cetak seperti brosur, spanduk, flayer dan promosi melalui media sosial seperti instagram, youtube, dan website yang dimana hanya menampilkan foto – foto kegiatan dan beberapa video cuplikan kegiatan yang sederhana dan belum ter-up to date. Tujuan dari penelitian ini adalah membantu SMA Plus Islamic Village Kabupaten Tangerang dalam menginformasikan dan mempromosikan dalam bentuk media video iklan yang dimana informasi yang divisualisasikan sudah ter-update, memperluas pangsa pasar serta dapat lebih dikenal oleh masyarakat luas. Manfaat penelitian ini ialah memberikan informasi kepada masyarakat dalam bentuk video iklan. Penelitian ini menggunakan metode penelitian pengumpulan data, analisa perancangan media dan konsep produksi media (KPM) yaitu:preproduction, production, dan postproduction. Hasil penelitiannya berupa media Video Iklan SMA Plus Islamic Village Kabupaten Tangerang. Melalui video iklan ini diharapkan dapat membantu pihak sekolah dalam memberikan informasi terbaru, membuat media promosi yang menarik.
Molybdenum and potassium in the foliar fertilization and seed quality in the soybean
Authors: Frota Rafael Tissot , Carvalho Ivan , Demari Gustavo Herique , Loro Murilo Vieira , Hutra Danieli Jacoboski , Lautenchleger ​Francine , Pedó Tiago , Aumonde Tiago Zanatta
Published: April 2021

Molybdenum is the micronutrient required in less quantity by plants and found in lower concentrations in Brazilian soils. The study aimed to study the influence of the application of molybdenum (Mo) and potassium (K) via foliar feeding, at different phenological stages, on the quality of soybean seeds. The work was conducted in the field in the county of Coronel Bicaco, RS under the condition of a typical dystropheric red Latosol (Oxisol) soil, in the 2017/2018 season crop. The experimental design was randomized blocks in a factorial scheme phenological stages x cultivars. Analysis of variance revealed significance for the interaction between phenological stages x cultivars for the variables composed by germination, abnormal, hard, dead, as well as field emergence, plant length and root length. There is influence of foliar feeding of molybdenum (Mo) and potassium (K) in different phenological stages of soybean. It was found that there was no significant difference for the yield of soybean cultivars under foliar feeding of Mo and K in the different treatments to which they were submitted.
Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Authors: Bastidas Torres Armando N. , Cats Davy , Out-Luiting Jacoba J. , Fanoni Daniele , Mei Hailiang , Venegoni Luigia , Willemze Rein , Vermeer Maarten H. , Berti Emilio , Tensen Cornelis P.
Published: April 2021

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of genetic alterations driving pcAECyTCL has been performed, nor effective therapeutic regimes for patients have been defined. Here, we present the first highresolution genetic characterization of pcAECyTCL by using wholegenome and RNA sequencing. Our study provides a comprehensive description of genetic alterations (i.e., genomic rearrangements, copy number alterations and small-scale mutations) with pathogenic relevance in this lymphoma, including events that recurrently impact genes with important roles in the cell cycle, chromatin regulation and the JAKSTAT pathway. In particular, we show that mutually exclusive structural alterations involving JAK2 and SH2B3 predominantly underlie pcAECyTCL. In line with the genomic data, transcriptome analysis uncovered upregulation of the cell cycle, JAK2 signaling, NF-κB signaling and a high inflammatory response in this cancer. Functional studies confirmed oncogenicity of JAK2 fusions identified in pcAECyTCL and their sensitivity to JAK inhibitor treatment. Our findings strongly suggest that overactive JAK2 signaling is a central driver of pcAECyTCL, and consequently, patients with this neoplasm would likely benefit from therapy with JAK2 inhibitors such as Food and Drug Adminstration-approved ruxolitinib.
IMAGE RESTORATION METHOD, INVARIANT TO SIGNAL CORRELATION IN THE INFORMATION SYSTEM WITH ADAPTIVE ANTENNA ARRAY
Authors:   Military academy, Skachkov V.V.
Published: April 2021

The problem of image signal processing in the information system with adaptive antenna array based on the inversion of sample estimates of correlation matrix of observations is considered. The example of the maximum signal-to-noise ratio criterion shows the problem, inherent in classical methods of finding the optimal weight vector under a priori uncertainty conditions when detecting correlated image signals. It has been concluded that the dependence of these methods on the inverse of estimation of the correlation matrix of observations leads to the impossibility of separating correlated image signals. As a consequence, the use of classical methods of finding the optimal weight vector in the information system with adaptive antenna array is effective only in the case of image restoration from a single signal source, with the signal received on the set of independent jamming background. A novel method, invariant to the correlation of image signals, has been developed for finding the optimal weight vector without the usage of correlation matrix of observations. An image restoration algorithm invariant to correlation of image signals in the information system with adaptive antenna array is proposed. Statistical models have been constructed for the classical method based on the criterion of maximum signal-to-noise ratio and invariant to correlation method of image restoration in following cases: a single source against the jamming background of two independent sources; two independent sources against the jamming background. Simulation results in the information system with adaptive antenna array are presented, showing to visually assess efficiency of proposed methods of image signal restoration using optimal weight vector. Detailed analysis of the results obtained is carried out.
Nesting frogs - the breeding biology of Indirana cf. tysoni in the
Western Ghats, India
Authors: Mudke Madhushri
Published: April 2021

Frogs of the genus Indirana are endemic to India. Previous research on these frogs has focussed on taxonomy and systematics but their behaviour remains largely understudied. Here we report the breeding behaviour of Indirana cf. tysoni, including nest building, male to male combat, inguinal amplexus, egg clutch guarding, tadpoles and polymorphism. We also analyse advertisement calls and present a comparative analysis with previously published data. Lastly, we discuss the need to study these breeding behaviours in-depth in order to help frame appropriate conservation plans.
MALĒCIYĀVIṈ MU.AṈPUCCELVAṈ ILAṄKAIYIṈ TI.NYĀṈACĒKARAṈ ĀKIYŌRIṈ CIṞUKATAIKAḶ ŌR OPPĀYVU [COMPARISON OF THE SHORT STORIES OF M.ANBUCHELVAN (MALAYSIA) AND T.NYANASEKARAN (SRI LANKA)]
Authors: SUBRAMANIAM KUNASEELAN
Published: April 2021

The objective of this study is to identify and compare the education issues of the plantation communities in selected Tamil short stories of Mu.Anbuchelvan (Malaysia) and T.Nyanasegaran (Sri Lanka) as well as to analyse the parallel elements in these issues. These short stories are selected based on the similarity of intrinsic elements that reflect plantation life and socioeconomic status. The analysis and discussions are based on comparative literary theory. The findings of this research shows that education issues are very similar among plantation communities in Malaysia and Sri Lanka. The implications of this study are important to understand the importance of Tamil short stories as historical sources of plantation communities in Malaysia and Sri Lanka.
Oppimisvaikeudet, toimintavalmiudet ja toimijuus elämänkulussa
Authors: Korkeamäki Johanna
Published: April 2021

Artikkelissa tarkastellaan tapaustutkimuksen keinoin kahden aikuisen kokemuksia oppimisvaikeuksista ja niihin saadusta tuesta osana elämänkulkua ja sosiaalisiin tekijöihin ja yhteiskunnalliseen kontekstiin kiinnittyneinä. Tutkimuksessa kysytään, millaiset yhteiskunnalliset reunaehdot ja rakenteelliset tekijät kehystävät toimijuutta ja toimintamahdollisuuksia oppimisvaikeuksia kokevilla aikuisilla. Teoreettisena näkökulmana hyödynnetään toimintavalmiusajattelua, jonka avulla tutkimus liitetään osaksi keskustelua koulutuksellisesta eriarvoisuudesta ja sosiaalisesta oikeudenmukaisuudesta. Tutkimuksen aineistona ovat kahden oppimisvaikeuksia kokevan aikuisen teemahaastattelut, joiden avulla tarkastellaan oppimisvaikeuksien merkitystä elämänkulussa eri elämänalueilla ja vaikeuksiin saatua tukea. Analyysimenetelmänä hyödynnetään temaattista sisällönanalyysia. Tutkimuksen tulokset tuovat esiin oppimisvaikeuksien pitkäaikaisia seurauksia elämänkulussa ja koulutuksen ja työelämän tarjoamaa tilaa toimintavalmiuksien kehkeytymiselle ja toimijuudelle. Tutkimus havainnollistaa iän, sukupuolen ja yhteiskuntaluokan merkitystä oppimisvaikeuksiin kytkeytyvissä kokemuksissa ja saatavilla olevissa resursseissa. Aikuisuus tuo uusia tulkintamahdollisuuksia aiemmille koulunkäyntivaikeuksille ja omille kyvyille, mikä on tärkeää toimintavalmiuksien kannalta. Tuloksia peilataan suomalaiseen aikuiskasvatukseen toimintavalmiusajattelun ja toimijuuden näkökulmasta.
Kortteja, kyyneleitä ja näpräämistä
Authors: Uusikylä Anu , Haapakangas Sari , Huuki Tuija
Published: April 2021

Tässä tutkimuksessa tarkastelemme oppilaan osallisuutta alakoulun kehityskeskustelussa affektiivisten ja materiaalisten ulottuvuuksien näkökulmasta. Feministisessä, uusmaterialistisessa ja posthumanistisessa tutkimuksessa on viime aikoina haastettu kielellisiä ja tekstuaalisia tutkimusmenetelmiä kehittämällä uusia metodologisia välineitä muun muassa kasvatustapahtumien tutkimiseen. Hyödyntämällä affektin, urittuvan ja silenevän tilan sekä yhteismuotoutumisen käsitteitä keskitymme havainnoimaan, miten tilat lapsen osallisuudelle avautuvat ja sulkeutuvat kehityskeskustelussa. Aineiston tuottamisen välineenä hyödynnämme tutkimusta varten kehitettyä pedagogis-menetelmällistä KESY-kuvamateriaalia, jonka tavoitteena on lisätä oppilaan osallisuutta kehityskeskustelussa ja samalla mahdollistaa osallisuuden moninaisten tilojen näkyväksi tekeminen. Tutkimusaineisto perustuu alakoulun kehityskeskusteluissa koottuihin kenttämuistiinpanoihin, valokuviin ja videoihin, joista lähempään tarkasteluun on poimittu kolme tapaamista. Ehdotamme, että tilaa osallisuudelle silentävät myönteinen affektiivinen ilmapiiri, kuvakortit ja liikehtiminen sekä kosketus materiaalisiin objekteihin. Osallisuutta urittavat aikuisten kiireinen ohjailu, normatiiviset odotukset ja puhekeskeisyys sekä koulun joustamattomat rakenteet ja käytänteet.
Cost-effectiveness analysis of caplacizumab in the new standard of care for immune Thrombotic Thrombocytopenic Purpura in Italy
Authors: Di Minno Giovanni , Ravasio Roberto
Published: April 2021

Objectives: To evaluate the cost-effectiveness analysis (CEA) of caplacizumab in combination with plasmapheresis (PEX) and immunosuppression compared to PEX and immunosuppression in the treatment of acute episodes of iTTP.

Methods: A Markov model was used to conduct the CEA from the perspective of the hospital, over a lifetime horizon. Clinical data derived from HERCULES trial and a systematic literature review. Economic input included direct costs only. Utility and disutility values were obtained from literature. Data on healthcare resources and costs were retrieved from HERCULES trial, literature, TTP guidelines and Italian tariffs. A sensitivity analysis was conducted. The cost-effectiveness probability was tested for several options of discount levels considering a suggested willingness to pay (WTP) threshold of € 60,000 in Italy.

Results: The use of caplacizumab in combination with PEX and immunosuppression is associated with a positive difference in survival of 3.27 life years (24.53 vs 21.26) and in quality of life of 3.06 QALY (22.01 vs 18.96) when compared to PEX and immunosuppression. Caplacizumab leads to an ICER per life years of € 41,653 and an ICER per QALY of € 44,572. For the suggested WTP threshold, the probability of caplacizumab being cost-effective is 82.4% (no discount), 92.8% (15% discount), 95.3% (20% discount), 96.9% (25% discount) and 98.2% (30% discount).

Conclusions: Caplacizumab in addition to PEX and immunosuppression is cost-effective, allowing the hospital to achieve greater efficiency in managing the burden of a life-threatening disease such as iTTP.
Pengembangan Mobile Learning Menggunakan Adobe Animate CC untuk Meningkatkan Motivasi dan Hasil Belajar Peserta Didik
Authors: Silvia Silvia , Bukhori Imam
Published: April 2021

Pandemi Covid-19 yang terjadi sejak akhir 2019 menyebar dengan cepat ke negara-negara di dunia, tidak terkecuali Indonesia. Banyak sektor telah terdampak oleh pandemi ini, Tidak terkecuali sektor pendidikan. Pembelajaran tidak lagi dilakukan secara tatap muka tapi dilakukan secara jarak jauh. Tujuan dari penelitian dan pengembangan ini adalah untuk 1) menghasilkan mobile learning berbasis android pada mata pelajaran korespondensi, 2) mengetahui tingkat kelayakan mobile learning melalui validasi ahli dan uji coba, 3) mengetahui perbedaan motivasi dan hasil belajar peserta didik. Metode penelitian dan pengambangan yang digunakan adalah metode penelitian dan pengembangan dari Borg & Gall yang telah dimodifikasi menjadi tujuh langkah: 1) tahap penelitian dan pengumpulan informasi awal; 2) tahap perencanaan; 3) tahap pengembangan format produk awal; 4) tahap validasi ahli; 5) tahap uji coba produk; 6) tahap revisi produk; dan 7) tahap produk akhir. Instrumen pengumpulan data menggunakan angket validasi ahli media, angket validasi ahli materi, angket uji coba, angket tingkat motivasi belajar peserta didik, dan posttest. Hasil validasi dan uji coba dinyatakan sangat layak dan penerapan produk berhasil meningkatkan motivasi dan hasil belajar peserta didik.
‘Eww wtf, what a dumb bitch’: a case study of similitudes inside gender-specific swearing patterns on Twitter
Authors: Gauthier Michael
Published: April 2021

Contrary to the idea which has been widespread for at least a hundred years that women differ substantially from men when they express themselves in English-speaking contexts (e.g., Jespersen, 1922 ; and Steadman, 1935 ), empirical studies have shown that these differences are often minimal and are not due to gender alone (e.g., Eckert, 2008 ; and Baker, 2014 ). This also frequently applies to the way they swear, despite certain preferences which have been documented in empirical studies. With the growing impact that social media now has in our everyday lives, these represent a unique opportunity to study vast quantities of written data. This paper is based on a corpus of about one-million tweets and is an attempt to delve deeper into the analysis of gendered swearword habits. First, the goal is to show that even if there are certain gendered preferences in terms of the choice of swearwords, women and men frequently display similar patterns in using them, thus reinforcing the idea that they are not so linguistically different. Secondly, this paper provides insights into how collocational networks can be used to achieve this, and thus how focussing on differences can be one way to spot similarities across two sub-corpora.
The Images, Technique and Stylistic Features of the Baroque Style in the Works of the Urals Stonecutters
Authors:   Ural State University of Architecture and Art, Alieva Olga O.
Published: April 2021

The article examines the particularities of the development in the Urals region of the genre of fi gurative sculpture of small forms from assembled stone by means of comparison with the art of the Italian masters from the baroque period, the establishers of this type of stonecutting art. The small fi gurative sculpture from assembled stone (polylite), which has developed as an independent genre of the art of stonecutting in the 17th century in Italy, acquired further development not only in Western Europe, but also in Russia, in the large-scale centers of artistic elaboration of stone in the country. In the region of the Ural Mountains, notwithstanding the pre-revolutionary conditions, the mastery of the principles of preparation of anthropomorphic images in the polylite technique took place only during the Soviet period as a particular school of preparation of specialists. At the contemporary stage it becomes possible to observe an active development of this genre in the artworks of the stonecutters of the Urals. The present-day fl ourishing of the polylite fi gurative sculpture of small forms in the works of the Urals-based stonecutters is connected here not only with the culture of elaborating this material and the successive continuity of the skills of working in the polylite technique, but also with the turn to the traditions of polychrome fi gurative compositions of Florentine masters of the Baroque Era, the effectiveness and naturalist qualities of their depiction.
Music, Mathematics and Computer Science: Features of Functioning of Computer-Musical Technologies
Authors:   Herzen State Pedagogical University of Russia, Gorbunova Irina B.
Published: April 2021

The lecture “Music, Mathematics and Computer Science” is subdivided into two parts. The fi rst part, “Music, Mathematics and Computer Science: History of Interaction” (see ICONI journal, No. 3, 2020) examines the processes of interconnection and interpenetration of various fi elds of music, mathematics and computer science, spanning the period from Ancient Times to the turn of the 20th and 21st centuries. The second part of the lecture: “Music, Mathematics and Computer Science: Particular Features of Functioning of Computer-Musical Technologies” is devoted to examining various aspects of developing and applying computer-musical technologies in contemporary musical practice, including musical composition, performance and the sphere of music education
Role Playing in Piano Instruction
Authors:   Scholarly-Methodical Center “Innovational Art Studies”, Shaymukhametova Liudmila N.
Published: April 2021

The article presents innovative forms of work with musical texts during piano lessons applied in work with beginning students in all conditions of teaching: in the academic educational process, as well as in private teaching practice of self-employed specialists. The reader shall be acquainted with concrete methodological elaborations of role playing which may be useful for the teacher in his or her practical work. The elaborations are carried out within the framework of one of the leading contemporary directions developed by the academic school of practical musical semantics. The presented homework assignments may serve as specimens for the creation of analogous elaborations by the teacher himself with substitutions of the musical material and with consideration of the pupils’ age-related capabilities. The author of the project, Liudmila Nikolayevna Shaymukhametova aspires to draw attention not only to new approaches to work with the musical text and to practical semantics as the most important direction in teaching music, but also to the question of what the contemporary textbook for the beginner musician should look like. The materials are addressed, among others, to upgrade training courses and professional retraining of teachers of schools, methodologists and teachers of general and professional education, as well as for application in practical work of private school teachers
Psychosocial Predictors of Quality of Life in Patients With Vitiligo
Authors: Nazar Iqra , Kamran Fatima , Masood Afsheen
Published: April 2021

The present study was designed to examine psychosocial predictors of quality of life (QoL) such as body image, self-esteem, impact of Vitiligo (psychologically and socially), and perceived stigmatization in patients with Vitiligo. The sample (N =120) comprised of individuals with Vitiligo recruited from dermatology units of different hospitals in Lahore. Body Image State Scale (Cash, Fleming, Alindogan, Steadman, & Whitehead 2002), Rosenberg Self-Esteem Scale (Rosenberg, 1965), Vitiligo Impact Scale (Rammam, Khaitan, Mehta, Sreenivas, & Gupta, 2014), Perceived Stigmatization Questionnaire (Lawrence, Fauerbach, Heinberg, & Thomas, 2006) and Dermatology Life Quality Index (Finlay & Khan, 1994) were used as assessment measures. Results revealed that most of the individuals with Vitiligo reported poorer perception of QoL; while, men with Vitiligo expressed better perceived QoL as compared to women. Individuals with both types of Vitiligo (lesions on exposed/unexposed regions) expressed poor body image, negative impact of Vitiligo on their psycho-social functioning, and higher levels of perceived stigmatization. Individuals with exposed Vitiligo affected regions exhibited lower self-esteem. In addition, body image, impact of Vitiligo (psychologically and socially), and perceived stigmatization (absence of friendly behavior) significantly predicted QoL. It was concluded that Vitiligo had a greater impact on individual’s psychological health and social functioning rather than physiological complications.
Gender Differences on COVID-19 Related Anxiety Among Students
Authors: Thahir Andi , Sulastri Sulastri , Zahra Bulantika Siti , Novita Tiara
Published: April 2021

The COVID-19 pandemic creates complex problems and in almost all aspects of life, everyone has been anxious, worried, and panicked about survival. Starting with children, young and old, men and women feel anxious about the threat of COVID-19. This study aimed to determine the differences in anxiety levels between male and female students during the COVID-19 period based on the Hamilton Anxiety Rating Scale (Hamilton, 1969). This study used a survey method with a descriptive design. Sampling using accidental sampling, 396 respondents consisted of 99 male and 297 female with age range of 21-23 years was acquired. Data analysis was based on univariate and bivariate analysis using Chi-Square. The results showed that overall respondents were experiencing high levels of anxiety about COVID-19. On the other hand, there was non-significant difference in anxiety levels between male and female students in facing the COVID-19 pandemic; thereby, indicating that gender did not have significant role in emotional reactivity, such as anxiety and fear. Anxiety would arise when there would be environmental pressures that can hinder one's activities of both male and female students.
Development and Validation of Gender Role Strain Scale for Men
Authors: Arshad Hana , Shahed Sarah
Published: April 2021

The main objective of present study was to develop an indigenous scale of Gender Role Strain Scale for Men (GRSS-M). Initially, an inclusive list of 33 items was compiled through conducting semi-structured interviews with one psychiatrist and three clinical psychologists, and performing a focus group with men. Ten experts were approached for content validity of GRSS-M and a list of 31 items was arranged after excluding two items. The Pilot Study (Phase 1) was carried out on a sample of 35 men from different professions, which revealed that GRSS-M items were easily comprehendible. In Phase 2, factor analysis was executed employing a sample of 400 men. Twenty five items were finalized with four emerging factors including Familial and Social Pressures, Marital Life Pressures, Financial Pressures, and Workplace Pressures with adequate alpha coefficients. The internal consistency of total GRSS-M was also found to be satisfactory. In Phase 3, psychometric properties of GRSS-M were established on sample of 200 men. The convergent validity of GRSS-M with Masculine Gender Role Stress Scale (Eisler & Skidmore, 1987) and discriminant validity of GRSS-M with Satisfaction with Life Scale (Diener, Emmons, Larsen, & Griffin, 1985) were acquired in desired direction. Significant mean differences were found through method of contrasted groups. The newly developed GRSS-M found to be a valid instrument with sound reliability for gauging role strain among Pakistani men.
Summary Visualizations of Gene Ontology Terms With GO-Figure!
Authors: Reijnders Maarten J. M. F. , Waterhouse Robert M.
Published: April 2021

The Gene Ontology (GO) is a cornerstone of functional genomics research that drives discoveries through knowledge-informed computational analysis of biological data from large-scale assays. Key to this success is how the GO can be used to support hypotheses or conclusions about the biology or evolution of a study system by identifying annotated functions that are overrepresented in subsets of genes of interest. Graphical visualizations of such GO term enrichment results are critical to aid interpretation and avoid biases by presenting researchers with intuitive visual data summaries. Amongst current visualization tools and resources there is a lack of standalone open-source software solutions that facilitate explorations of key features of multiple lists of GO terms. To address this we developed GO-Figure!, an open-source Python software for producing user-customisable semantic similarity scatterplots of redundancy-reduced GO term lists. The lists are simplified by grouping together terms with similar functions using their quantified information contents and semantic similarities, with user-control over grouping thresholds. Representatives are then selected for plotting in two-dimensional semantic space where similar terms are placed closer to each other on the scatterplot, with an array of user-customisable graphical attributes. GO-Figure! offers a simple solution for command-line plotting of informative summary visualizations of lists of GO terms, designed to support exploratory data analyses and dataset comparisons.
Challenges and Approaches to Scaling the Global Commons
Authors: Fritsch Felix , Emmett Jeff , Friedman Emaline , Kranjc Rok , Manski Sarah , Zargham Michael , Bauwens Michel
Published: April 2021

The re-emergence of commoning over the last decades is not incidental, but rather indicative of a large-scale transition to a more “generative” organization of society that is oriented toward the planet’s global carrying capacity. Digital commons governance frameworks are of particular importance for a new global paradigm of cooperation, one that can scale the organization of communities around common goals and resources to unprecedented levels of size, complexity and granularity. Distributed Ledger Technologies (DLTs) such as blockchain have lately given new impetus to the emergence of a new generation of authentic “sharing economy,” protected from capture by thorough distribution of power over infrastructure, that spans not only digital but also physical production of common value. The exploration of the frontiers of DLT-based commoning at the heart of this article considers three exemplary cases for this new generation of commons-oriented community frameworks: the Commons Stack, Holochain and the Commons Engine, and the Economic Space Agency. While these projects differ in their scope as well as in their relation to physical common-pool resources (CPRs), they all share the task of redefining markets so as to be more conducive to the production and sustainment of common value(s). After introducing each of them with regards to their specificities and commonalities, we analyze their capacity to foster commons-oriented economies and “money for the commons” that limit speculation, emphasize use-value over exchange-value, favor equity in human relations, and promote responsibility for the preservation of natural habitats. Our findings highlight the strengths of DLTs for a federated scaling of CPR governance frameworks that accommodates rather than obliterates cultural differences and creates webs of fractal belonging among nested communities.
RETRACTED: Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering
Authors: Tian Feng , Zhang Ying
Published: April 2021

Our previous research has shown that type-2a Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a) undergoes posttranscriptional oxidative modifications in cardiac microvascular endothelial cells (CMECs) in the context of excessive cardiac oxidative injury. However, whether SERCA2a inactivity induces cytosolic Ca2+ imbalance in mitochondrial homeostasis is far from clear. Mitofusin2 (Mfn2) is well known as an important protein involved in endoplasmic reticulum (ER)/mitochondrial Ca2+ tethering and the regulation of mitochondrial quality. Therefore, the aim of our study was to elucidate the specific mechanism of SERCA2a-mediated Ca2+ overload in the mitochondria via Mfn2 tethering and the survival rate of the heart under conditions of cardiac microvascular ischemic injury. In vitro, CMECs extracted from mice were subjected to 6 h of hypoxic injury to mimic ischemic heart injury. C57-WT and Mfn2KO mice were subjected to a 1 h ischemia procedure via ligation of the left anterior descending branch to establish an in vivo cardiac ischemic injury model. TTC staining, immunohistochemistry and echocardiography were used to assess the myocardial infarct size, microvascular damage, and heart function. In vitro, ischemic injury induced irreversible oxidative modification of SERCA2a, including sulfonylation at cysteine 674 and nitration at tyrosine 294/295, and inactivation of SERCA2a, which initiated calcium overload. In addition, ischemic injury-triggered [Ca2+]c overload and subsequent [Ca2+]m overload led to mPTP opening and ΔΨm dissipation compared with the control. Furthermore, ablation of Mfn2 alleviated SERCA2a-induced mitochondrial calcium overload and subsequent mito-apoptosis in the context of CMEC hypoxic injury. In vivo, compared with that in wild-type mice, the myocardial infarct size in Mfn2KO mice was significantly decreased. In addition, the findings revealed that Mfn2KO mice had better heart contractile function, decreased myocardial infarction indicators, and improved mitochondrial morphology. Taken together, the results of our study suggested that SERCA2a-dependent [Ca2+]c overload led to mitochondrial dysfunction and activation of Mfn2-mediated [Ca2+]m overload. Overexpression of SERCA2a or ablation of Mfn2 expression mitigated mitochondrial morphological and functional damage by modifying the SERCA2a/Ca2+-Mfn2 pathway. Overall, these pathways are promising therapeutic targets for acute cardiac microvascular ischemic injury.
Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production
Authors: Chen Xiaoting , Wu Mian , Liang Nan , Lu Junxi , Qu Shen , Chen Haibing
Published: April 2021

The relationship between thyroid hormones and serum urate is unclear. Our aim is to analyze the correlation between uric acid and thyroid hormones in gout patients and to explore the effect and mechanism of triiodothyronine on liver uric acid production. Eighty men patients with gout were selected to analyze the correlation between blood urate and thyroid function-related hormone levels. Stepwise multiple linear regression was used to analyze factors affecting blood urate in patients with gout. Levels of urate in serum, liver, and cell culture supernatant were measured after triiodothyronine treatment. Purine levels (adenine, guanine, and hypoxanthine) were also measured. Expression levels of Period2 and nucleotide metabolism enzymes were analyzed after triiodothyronine treatment and Period2-shRNA lentivirus transduction. Chromatin immunoprecipitation was used to analyze the effects of triiodothyronine and thyroid hormone receptor-β on Period2 expression. The results showed that in patients FT3 influenced the serum urate level. Furthermore, urate level increased in mouse liver and cell culture supernatant following treatment with triiodothyronine. Purine levels in mouse liver increased, accompanied by upregulation of enzymes involved in nucleotide metabolism. These phenomena were reversed in Period2 knockout mice. Triiodothyronine promoted the binding of thyroid hormone receptor-β to the Period2 promoter and subsequent transcription of Period2. Triiodothyronine also enhanced nuclear expression of Sirt1, which synergistically enhanced Period2 expression. The study demonstrated that triiodothyronine is independently positively correlated with serum urate and liver uric acid production through Period2, providing novel insights into the purine metabolism underlying hyperuricemia/gout pathophysiology.
Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma
Authors: Sivasudhan Enakshi , Blake Neil , Lu Zhi-Liang , Meng Jia , Rong Rong
Published: April 2021

Epidemiological data consistently rank hepatocellular carcinoma (HCC) as one of the leading causes of cancer-related deaths worldwide, often posing severe economic burden on health care. While the molecular etiopathogenesis associated with genetic and epigenetic modifications has been extensively explored, the biological influence of the emerging field of epitranscriptomics and its associated aberrant RNA modifications on tumorigenesis is a largely unexplored territory with immense potential for discovering new therapeutic approaches. In particular, the underlying cellular mechanisms of different hallmarks of hepatocarcinogenesis that are governed by the complex dynamics of m6A RNA methylation demand further investigation. In this review, we reveal the up-to-date knowledge on the mechanistic and functional link between m6A RNA methylation and pathogenesis of HCC.
Targeting the Complement Pathway in Malignant Glioma Microenvironments
Authors: Zhu Hongtao , Yu Xingjiang , Zhang Suojun , Shu Kai
Published: April 2021

Malignant glioma is a highly fatal type of brain tumor, and its reoccurrence is largely due to the ordered interactions among the components present in the complex microenvironment. Besides its role in immune surveillance and clearance under physiological conditions, the complement system is expressed in a variety of tumor types and mediates the interactions within the tumor microenvironments. Recent studies have uncovered the broad expression spectrum of complement signaling molecules in the tumor microenvironment and various tumor cells, in particular, malignant glioma cells. Involvement of the complement system in tumor growth, immunosuppression and phenotype transition have also been elucidated. In this review, we enumerate the expression and function of complement molecules in multiple tumor types reported. Moreover, we elaborate the complement pathways in glioma cells and various components of malignant glioma microenvironments. Finally, we summarize the possibility of the complement molecules as prognostic factors and therapeutic targets in the treatment of malignant glioma. Specific targeting of the complement system maybe of great significance and value in the future treatment of multi-type tumors including malignant glioma.
The Metallogeny of the Lubei Ni–Cu–Co Sulfide Deposit in Eastern Tianshan, NW China: Insights From Petrology and Sr–Nd–Hf Isotopes
Authors: Li Ping , Liang Ting , Feng Yonggang , Zhao Tongyang , Tian Jiangtao , Li Dahai , Li Jian , Chen Gang , Wu Changzhi
Published: April 2021

The Lubei Ni–Cu–Co deposit situated in western segment of the Huangshan-Jing’erquan mafic–ultramafic rock belt in eastern Tianshan of the Central Asian Orogenic Belt (CAOB). The estimated reserve is approximately 9.11 million tons of ore resources with average grades of 0.82 wt% Ni, 0.52 wt% Cu, and 0.03 wt% Co. The Lubei intrusion is mainly composed of gabbro (phase I), peridotite (phase II), pyroxene peridotite (phase III), olivine pyroxenite (phase IV), and diorite (phase V), which intruded into the early Carboniferous tuffaceous clastic rocks. Zircon Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry (LA–ICP–MS) U–Pb age of the diorite (phase V) from the edge of the intrusion is interpreted as the top-limit metallogenic age, which is consistent with the formation ages of the Huangshan and Xiangshan Ni–Cu deposits in eastern Tianshan. The roughly parallel rare earth element (REE) curves of the Lubei intrusion indicate the magma originated from a homologous source. The slightly enriched large ion lithophile elements (LILE) are compared to high field strength elements (HFSE) with negative Nb and Ta anomalies show that the Lubei intrusion has arc-affiliate geochemical characteristics. The Sr–Nd–Hf isotopes show that the magma was derived from depleted lithospheric mantle, while suffering 4–10% lower crustal contamination with slight contamination of the upper crust. Based on a comprehensive conservation of regional geological, geochemical, and geochronological evidence, the primary magma of the Lubei intrusion was identified that it was derived from the partial melting of metasomatized lithospheric mantle previously modified by subduction events. The Lubei nickel–copper–cobalt sulfide deposit was formed after the primary magma experienced fractional crystallization, crustal contamination, and sulfide segregation in a post-collisional extensional geodynamic setting after the closure of the Kanggur ocean basin in the early Permian.
Pre-service Teachers’ Decision-Making and Classroom Assessment Practices
Authors: Oo Cherry Zin , Alonzo Dennis , Davison Chris
Published: April 2021

Classroom assessment practices play a pivotal role in ensuring effective learning and teaching. One of the most desired attributes of teachers is the ability to gather and analyze assessment data to make trustworthy decisions leading to supporting student learning. However, this ability is often underdeveloped for a variety of reasons, including reports that teachers are overwhelmed by the complex process of data analysis and decision-making and that often there is insufficient attention to authentic assessment practices which focus on assessmentforlearning (AfL) in initial teacher education (ITE), so teachers are uncertain how to integrate assessment into teaching and make trustworthy assessment decisions to develop student learning. This paper reports on the results of a study of the process of pre-service teachers’ (PSTs) decision-making in assessment practices in Myanmar with real students and in real classroom conditions through the lens of teacher agency. Using a design-based research methodology, a needs-based professional development program for PSTs’ assessment literacy was developed and delivered in one university. Following the program, thirty PSTs in the intervention group were encouraged to implement selected assessment strategies during their practicum. Semi-structured individual interviews were undertaken with the intervention group before and after their practicum in schools. This data was analyzed together with data collected during their practicum, including lesson plans, observation checklists and audiotapes of lessons. The analysis showed that PSTs’ decision-making in the classroom was largely influenced by their beliefs of and values in using assessment strategies but, importantly, constrained by their supervising teachers. The PSTs who understood the principles of AfL and wanted to implement on-going assessment experienced tension with supervising teachers who wanted to retain high control of the practicum. As a result, most PSTs could not use assessment strategies effectively to inform their decisions about learning and teaching activities. Those PSTs who were allowed greater autonomy during their practicum and understood AfL assessment strategies had greater freedom to experiment, which allowed them multiple opportunities to apply the result of any assessment activity to improve both their own teaching and students’ learning. The paper concludes with a discussion of the kind of support PSTs need to develop their assessment decision-making knowledge and skills during their practicum.
The Utility of Macroecological Rules for Microbial Biogeography
Authors: Dickey Jonathan R. , Swenie Rachel A. , Turner Sophia C. , Winfrey Claire C. , Yaffar Daniela , Padukone Anchal , Beals Kendall K. , Sheldon Kimberly S. , Kivlin Stephanie N.
Published: April 2021

Macroecological rules have been developed for plants and animals that describe large-scale distributional patterns and attempt to explain the underlying physiological and ecological processes behind them. Similarly, microorganisms exhibit patterns in relative abundance, distribution, diversity, and traits across space and time, yet it remains unclear the extent to which microorganisms follow macroecological rules initially developed for macroorganisms. Additionally, the usefulness of these rules as a null hypothesis when surveying microorganisms has yet to be fully evaluated. With rapid advancements in sequencing technology, we have seen a recent increase in microbial studies that utilize macroecological frameworks. Here, we review and synthesize these macroecological microbial studies with two main objectives: (1) to determine to what extent macroecological rules explain the distribution of host-associated and free-living microorganisms, and (2) to understand which environmental factors and stochastic processes may explain these patterns among microbial clades (archaea, bacteria, fungi, and protists) and habitats (host-associated and free living; terrestrial and aquatic). Overall, 78% of microbial macroecology studies focused on free living, aquatic organisms. In addition, most studies examined macroecological rules at the community level with only 35% of studies surveying organismal patterns across space. At the community level microorganisms often tracked patterns of macroorganisms for island biogeography (74% confirm) but rarely followed Latitudinal Diversity Gradients (LDGs) of macroorganisms (only 32% confirm). However, when microorganisms and macroorganisms shared the same macroecological patterns, underlying environmental drivers (e.g., temperature) were the same. Because we found a lack of studies for many microbial groups and habitats, we conclude our review by outlining several outstanding questions and creating recommendations for future studies in microbial ecology.
A Novel FLCN Intragenic Deletion Identified by NGS in a BHDS Family and Literature Review
Authors: Cai Minghui , Zhang Xinxin , Fan Lizhen , Cheng Shuwen , Kiram Abdukahar , Cen Shaoqin , Chen Baofu , Ye Minhua , Gao Qian , Zhu Chengchu , Yi Long , Ma Dehua
Published: April 2021

Birt–Hogg–Dubé syndrome (BHDS, MIM #135150), caused by germline mutations of FLCN gene, is a rare autosomal dominant inherited disorder characterized by skin fibrofolliculomas, renal cancer, pulmonary cysts and spontaneous pneumothorax. The syndrome is considered to be under-diagnosed due to variable and atypical manifestations. Herein we present a BHDS family. Targeted next generation sequencing (NGS) and multiplex ligation-dependent probe amplification (MLPA) revealed a novel FLCN intragenic deletion spanning exons 10-14 in four members including the proband with pulmonary cysts and spontaneous pneumothorax, one member with suspicious skin lesions and a few pulmonary cysts, as well as two asymptomatic family members. In addition, a linkage analysis further demonstrated one member with pulmonary bullae to be a BHDS-ruled-out case, whose bullae presented more likely as an aspect of paraseptal emphysema. Furthermore, the targeted NGS and MLPA data including our previous and present findings were reviewed and analyzed to compare the advantages and disadvantages of the two methods, and a brief review of the relevant literature is included. Considering the capability of the targeted NGS method to detect large intragenic deletions as well as determining deletion junctions, and the occasional false positives of MLPA, we highly recommend targeted NGS to be used for clinical molecular diagnosis in suspected BHDS patients.