bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the Nexus between Social Commerce, Green Customer Citizenship, Eco-Friendly Behavior and Staying in Green Hotels
Authors: Elshaer Ibrahim A. , Alyahya Mansour , Azazz Alaa M. S. , Mansour Mahmoud A. , Mohammad Abuelkassem A. A. , Fayyad Sameh
Published: February 2024

Understanding the factors and motivations that drive consumers to engage in eco-friendly behavior within the realm of social commerce is essential to provide insights into crafting targeted marketing efforts and campaigns. By aligning eco-friendly initiatives with the inherent motivations of social commerce users, businesses can enhance the effectiveness of their sustainability efforts. Despite that, limited research has investigated the potential impact of social commerce, aligned with green customer citizenship, on eco-friendly behavior and staying in green hotels. To address this gap, this study aims to examine the level to which social commerce practices contribute to shaping customers’ eco-friendly behavior in the context of eco-friendly hotels. A quantitative approach design using a questionnaire survey to collect primary data was conducted. Based on valid responses from 336 participants, a structured equation modeling was performed using Smart PLS 4.0 to examine the conceptual model and justify the hypotheses of the study. The findings highlighted the critical role of social commerce in shaping customer eco-friendly behavior and staying in green hotels. The results also confirmed the moderating role of green customer citizenship in supporting the linkage between social commerce and customer eco-friendly behavior in hotel settings. These results contribute to the growing hospitality body of knowledge and provide some valuable practical implications enabling eco-friendly hotels to leverage social commerce as a medium for promoting green initiatives and services.
New Generalized Weibull Inverse Gompertz Distribution: Properties and Applications
Authors: Baharith Lamya A.
Published: February 2024

In parametric statistical modeling, it is essential to create generalizations of current statistical distributions that are more flexible when modeling actual data sets. Therefore, this study introduces a new generalized lifetime model named the odd Weibull Inverse Gompertz distribution (OWIG). The OWIG is derived by combining the odd Weibull family of distributions with the inverse Gompertz distribution. Essential statistical properties are discussed, including reliability functions, moments, Rényi entropy, and order statistics. The proposed OWIG is particularly significant as its hazard rate functions exhibit various monotonic and nonmonotonic shapes. This enables OWIG to model different hazard behaviors more commonly observed in natural phenomena. OWIG’s parameters are estimated and its flexibility in predicting unique symmetric and asymmetric patterns is shown by analyzing real-world applications from psychology, environmental, and medical sciences. The results demonstrate that the proposed OWIG is an excellent candidate as it provides the most accurate fits to the data compared with some competing models.
Transcriptomic Investigation in CRISPR/Cas9-Mediated GRIK1-, GRIK2-, and GRIK4-Gene-Knockout Human Neuroblastoma Cells
Authors: Hu Tsung-Ming , Hsu Shih-Hsin , Tsai Hsin-Yao , Cheng Min-Chih
Published: February 2024

The glutamate ionotropic kainate receptors, encoded by the GRIK gene family, are composed of four subunits and function as ligand-activated ion channels. They play a critical role in regulating synaptic transmission and various synaptic receptors’ processes, as well as in the pathophysiology of schizophrenia. However, their functions and mechanisms of action need to be better understood and are worthy of exploration. To further understand the exact role of the kainate receptors in vitro, we generated kainate-receptor-knockout (KO) isogenic SH-SY5Y cell lines using the CRISPR/Cas9-mediated gene editing method. We conducted RNA sequencing (RNA-seq) to determine the differentially expressed genes (DEGs) in the isogenic edited cells and used rhodamine-phalloidin staining to quantitate filamentous actin (F-actin) in differentiated edited cells. The RNA-seq and the Gene Ontology enrichment analysis revealed that the genetic deletion of the GRIK1, GRIK2, and GRIK4 genes disturbed multiple genes involved in numerous signal pathways, including a converging pathway related to the synaptic membrane. An enrichment analysis of gene–disease associations indicated that DEGs in the edited cell lines were associated with several neuropsychiatric disorders, especially schizophrenia. In the morphology study, fluorescent images show that less F-actin was expressed in differentiated SH-SY5Y cells with GRIK1, GRIK2, or GRIK4 deficiency than wild-type cells. Our data indicate that kainate receptor deficiency might disturb synaptic-membrane-associated genes, and elucidating these genes should shed some light on the pathophysiology of schizophrenia. Furthermore, the transcriptomic profiles for kainate receptor deficiency of SH-SY5Y cells contribute to emerging evidence for the novel mechanisms underlying the effect of kainate receptors and the pathophysiology of schizophrenia. In addition, our data suggest that kainate-receptor-mediated F-actin remodeling may be a candidate mechanism underlying schizophrenia.
Examining Cross-Industry Clusters among Airline and Tourism Industries
Authors: Liasidou Sotiroula
Published: February 2024

Cross-industry clusters are essential for the economic prosperity of a region. However, studies do not address competitive clusters among the airline and tourism industries. Thus, this paper considers the case of both industries in terms of the clusters and synergies formed. This research aim is to provide an understanding of both industries’ protagonists’ involvement in contributing to insights into the establishment of synergies or clusters among the two industries. Cyprus is highly dependent on tourism and airlines because they facilitate connectivity. The research comprises semi-structured interviews with the leading players and organizations of the airline and tourism industries (government bodies, airports, airlines, tour operators and hotels). The results indicate that in a small geographical context, the notion of clusters involves a synergetic relationship among tourism stakeholders. The airlines’ role is essential and affects all stakeholders involved in tourism. Additionally, the research provides new insights into the role of Destination Management Organisations (DMOs) in providing applicable tourism policies that can positively impact effective cooperation among industry partners.
Toxic Effects of Bt-(Cry1Ab+Vip3Aa) Maize on Storage Pest Paralipsa gularis (Zeller)
Authors: Chen Shuang , Wang Wenhui , Kang Guodong , Yang Xianming , Wu Kongming
Published: February 2024

Paralipsa gularis (Zeller) is a storage pest; however, in recent years it has evolved into a considerable maize pest during the late growth stage in the border region between China and other Southeast Asian countries. Bt transgenic insect-resistant maize is an effective measure in controlling a wide range of lepidopteran pests, but there is a lack of research on the toxic effects of storage pests. We tested the toxicity of Bt-Cry1Ab, Vip3Aa, and their complex proteins against P. gularis via bioassay and investigated the efficiency of Bt-(Cry1Ab+Vip3Aa) maize in controlling P. gularis during the late growth stage of maize in the period 2022–2023. The bioassay results show that the susceptibilities of P. gularis to the two Bt proteins and their complex proteins were significantly different. The LC50 values of DBNCry1Ab (“DBN9936” event), DBNVip3Aa (“DBN9501” event), DBN Cry1Ab+Vip3Aa (“DBN3601T” event), and Syngenta Cry1Ab+Vip3Aa (“Bt11” event × “MIR162” event) were 0.038 μg/g, 0.114 μg/g, 0.110 μg/g, and 0.147 μg/g, and the GIC50 values were 0.014 μg/g, 0.073 μg/g, 0.027 μg/g, and 0.026 μg/g, respectively. Determination of the expression content of the insecticidal protein in different tissues of Bt-(Cry1Ab+Vip3Aa) maize shows that the total Bt protein content in different tissues was in the following order: stalk > bract > cob > kernel. However, the bioassay results show that the mortalities of P. gularis feeding on Bt-(Cry1Ab+Vip3Aa) maize in different tissues at different growth stages were all above 93.00%. The field trial indicates that the occurrence density of larvae and plant damage rate for conventional maize were 422.10 individuals/100 plants and 94.40%, respectively, whereas no larvae were found on Bt-(Cry1Ab+Vip3Aa) maize. In summary, this study implies that Bt-(Cry1Ab+Vip3Aa) maize has a high potential for control of P. gularis, providing a new technical measure for the management of the pest.
Predatory and Defensive Strategies in Cone Snails
Authors: Ratibou Zahrmina , Inguimbert Nicolas , Dutertre Sébastien
Published: February 2024

Cone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland. The pharmacology of cone snail venom has been increasingly investigated over more than half a century. The rising interest in cone snails was initiated by the surprising high human lethality rate caused by the defensive stings of some species. Although a vast amount of information has been uncovered on their venom composition, pharmacological targets, and mode of action of conotoxins, the venom–ecology relationships are still poorly understood for many lineages. This is especially important given the relatively recent discovery that some species can use different venoms to achieve rapid prey capture and efficient deterrence of aggressors. Indeed, via an unknown mechanism, only a selected subset of conotoxins is injected depending on the intended purpose. Some of these remarkable venom variations have been characterized, often using a combination of mass spectrometry and transcriptomic methods. In this review, we present the current knowledge on such specific predatory and defensive venoms gathered from sixteen different cone snail species that belong to eight subgenera: Pionoconus, Chelyconus, Gastridium, Cylinder, Conus, Stephanoconus, Rhizoconus, and Vituliconus. Further studies are needed to help close the gap in our understanding of the evolved ecological roles of many cone snail venom peptides.
Stability of Genotube® Swabs for African Swine Fever Virus Detection Using Loop-Mediated Isothermal (LAMP) Laboratory Testing on Samples Stored without Refrigeration
Authors: Phillips Dianne , Conceicao Felisiano da , Jong Joanita Bendita da Costa , Rawlin Grant , Mee Peter
Published: February 2024

African swine fever (ASF) is a transboundary viral disease which causes high mortality in pigs. In many low- and middle-income countries and in remote areas where diagnostic surveillance for ASF virus (ASFV) is undertaken, access to trained animal health technicians, sample collection, cold chain storage and transport of samples to suitably equipped laboratories can be limiting when traditional sampling and laboratory tests are used. Previously published studies have demonstrated that alternative sampling matrices such as swabs and filter papers can be tested using PCR without refrigeration for up to a week. This study used Genotube® swabs stored in temperate and tropical climates without refrigeration for four weeks after collection to demonstrate there was no change in test performance and results using loop-mediated isothermal amplification (LAMP) ASFV detection on a series of pig serum samples including serum spiked with a synthetic ASFV positive control, naturally acquired ASFV positive serum from Timor-Leste and negative ASFV serum samples. The use of Genotube® swabs for ASFV detection for surveillance purposes, coupled with testing platforms such as LAMP, can provide an alternative to traditional testing methodology where resources are limited and time from collection to testing of samples is prolonged.
Temporal Trends in Syphilis Incidence among Men with HIV in Busan, Korea, 2005–2022: A Retrospective Cohort Study
Authors: Lee Sun Hee , Lee Jeong Eun , Lee Soon Ok , Lee Shinwon , Ko Woo Seog , Kim Hyung-Hoi , Shin Kyung-Hwa , Kang Jin Suk , Son Hyunjin
Published: February 2024

We aimed to assess the temporal trends of incident syphilis and its associated risk factors among men with HIV (Human Immunodeficiency Virus) in Korea during the COVID-19 pandemic. We conducted a retrospective cohort study of men with HIV attending an HIV clinic in Korea between 2005 and 2022. Of 767 men with HIV, 499 were included and contributed 3220 person-years (PY) of the observation period. Eighty-two patients were diagnosed with incident syphilis, with an overall incidence of 2.55/100 PY (95% confidence interval [CI] 20.56–31.53). The incidence of syphilis per 100 PY gradually decreased from 2.43 (0.79–7.42) in 2005–2007 to 1.85 (1.08–3.17) in 2014–2016; however, it increased to 3.0 (1.99–4.53) in 2017–2019, and further to 3.33 (2.26–4.89) in 2020–2022. A multivariate analysis identified young age (≤30 years versus >50, adjusted HR 6.27, 95% CI 2.38–16.56, p < 0.001), treponemal test positive at baseline (2.33, 1.48–3.67, p < 0.001), men who have sex with men (2.36, 1.34–4.16, p = 0.003), and history of incarceration (2.62, 1.21–5.67, p = 0.015) as risk factors for incident syphilis. Recently, syphilis incidence in men with HIV has increased in Korea, especially in young patients and at-risk groups, highlighting the need for enhanced regular screening and targeted behavioral interventions among these populations.
Cybersickness in Virtual Reality: The Role of Individual Differences, Its Effects on Cognitive Functions and Motor Skills, and Intensity Differences during and after Immersion
Authors: Kourtesis Panagiotis , Papadopoulou Agapi , Roussos Petros
Published: February 2024

Background: Given that VR is used in multiple domains, understanding the effects of cybersickness on human cognition and motor skills and the factors contributing to cybersickness is becoming increasing important. This study aimed to explore the predictors of cybersickness and its interplay with cognitive and motor skills. Methods: 30 participants, 20–45 years old, completed the MSSQ and the CSQ-VR, and were immersed in VR. During immersion, they were exposed to a roller coaster ride. Before and after the ride, participants responded to the CSQ-VR and performed VR-based cognitive and psychomotor tasks. After the VR session, participants completed the CSQ-VR again. Results: Motion sickness susceptibility, during adulthood, was the most prominent predictor of cybersickness. Pupil dilation emerged as a significant predictor of cybersickness. Experience with videogaming was a significant predictor of cybersickness and cognitive/motor functions. Cybersickness negatively affected visuospatial working memory and psychomotor skills. Overall the intensity of cybersickness’s nausea and vestibular symptoms significantly decreased after removing the VR headset. Conclusions: In order of importance, motion sickness susceptibility and gaming experience are significant predictors of cybersickness. Pupil dilation appears to be a cybersickness biomarker. Cybersickness affects visuospatial working memory and psychomotor skills. Concerning user experience, cybersickness and its effects on performance should be examined during and not after immersion.
Phthalates in Surface Waters of the Selenga River (Main Tributary of Lake Baikal) and Its Delta: Spatial-Temporal Distribution and Environmental Risk Assessment
Authors: Taraskin Vasilii V. , Budaeva Olga D. , Nikitina Elena P. , Shiretorova Valentina G. , Bazarsadueva Selmeg V. , Nikolaev Yuri N. , Tykheev Zhargal A. , Zhigzhitzhapova Svetlana V. , Bazarzhapov Tcogto Zh. , Pintaeva Evgeniya Ts. , Radnaeva Larisa D. , Ayurzhanaev Aleksander A. , Shirapova Sendema D. , Tsyrendorzhieva Tatyana B. , Batorova Galina N. , Garmaev Endon Zh.
Published: February 2024

The Selenga River provides about half of the water and chemical runoff into Lake Baikal and plays an important role in the sustainability of the ecosystem of this large natural freshwater lake. Phthalate esters (PAEs) are organic compounds that can disrupt reproductive and endocrine systems. This study focused on investigating the distribution of six priority phthalates in the Selenga River and its delta utilizing SPE-GC/MS. The study found that the highest levels of Σ6PAE were observed during the high-water years, 2021 and 2023, and were evenly distributed along the river from the sampling sites upstream of Ulan-Ude to the delta channels. In contrast, the mean annual Σ6PAE content was relatively low in the low water period of 2022. Dibutyl phthalate (DBP) and di-(2-ethylhexyl) phthalate (DEHP) are the two dominant phthalates found in the surface waters of the Selenga River and delta channels. In 2021, the average total concentration of six phthalates (Σ6PAE) ranged from 8.84 to 25.19 µg/L, while in 2022 it ranged from 0.45 to 4.01 µg/L, and in 2023 it ranged from 5.40 to 21.08 µg/L. The maximum level for the sum of phthalates was 61.64 µg/L in 2021, 13.57 µg/L in 2022, and 30.19 µg/L in 2023. The wastewater treatment facilities in Ulan-Ude were identified as a stable local source of phthalates. In some cases, PAE concentrations exceeded maximum allowable concentrations, particularly for DEHP. This could have adverse effects on aquatic organisms.
The Effects of a Fishery Complementary Photovoltaic Power Plant on the Near-Surface Meteorology and Water Quality of Coastal Aquaculture Ponds
Authors: Song Fawen , Lu Zhiqiang , Guo Zhouhua , Wang Yi , Ma Li
Published: February 2024

To date, most studies focus on the ecological and environmental effects of land-based photovoltaic (PV) power plants, while there is a dearth of studies examining the impacts of water-based PV power plants. The effects of a fishery complementary PV power plant, a kind of water-based PV technology, on the near-surface meteorology and aquaculture water environment were investigated in coastal aquaculture ponds in southeast China. The results showed that PV prevented 89~93% of the solar radiation on the surface of the pond, resulting in an average reduction in water temperature of 1.5 °C and a substantial decrease in light intensity of 94%. Furthermore, it weakened the wind speed by 41~50% and elevated the surface air temperature by an average of 0.6 °C. In addition, PV power results in an impressive decrease in chlorophyll-α of 72~94% and a notable increase in dissolved oxygen (DO) concentrations of 8~24%. PV power also reduced the concentration of labile phosphate, active silicate, total nitrogen, total phosphorus, and total organic carbon. However, the PV power did not have a substantial influence on the concentrations of nitrate and ammonium. Our results highlight that fishery complementary PV power plants may be able to improve water quality and benefit shade-loving species.
Assessment of Hydrological Responses to Land Use and Land Cover Changes in Forest-Dominated Watershed Using SWAT Model
Authors: Ware Hiyaw Hatiya , Chang Sun Woo , Lee Jeong Eun , Chung Il-Moon
Published: February 2024

Recognizing how human activities affect hydrological systems is vital for the sustainable preservation and effective management of water resources in the watershed. Hence, this paper focuses on the hydrological response to land use and land cover (LULC) change scenarios in the Anyang watershed, South Korea. We obtained LULC data maps for the years 2000, 2013, and 2022 from the local government, revealing significant changes over the years. Agricultural lands experienced a 6.2% increase from 2000 to 2022, and pastureland expanded by 8.67% over two decades. The SWAT model was utilized to assess the impact of LULC on the hydrological components of the study watershed. Model calibration and validation for each LULC change were carried out using the SWAT-CUP program, considering the recorded streamflow information of the region. An excellent agreement was reached between the simulated and measured streamflow in both the calibration and validation stages under various LULC conditions. The Nash–Sutcliffe model efficiency (NSE), the objective function, demonstrated values of 0.9, 0.89, and 0.89 during the calibration for 2000, 2013, and 2022, respectively, in the LULC scenario, while for the validation, we obtained values of 0.82, 0.78, and 0.80 for 2000, 2013, and 2022, respectively. Our findings indicate that the surface runoff rise contributed much to the water yield increase over the two decades compared to the other components in terms of the water yield, while the contribution of evapotranspiration (ET) to the watershed hydrological cycle declined by 1.66% from 2000 to 2022. The southeastern sub-basin part showed a high groundwater recharge distribution due to agricultural land, rice area, and forest area changes.
Influence of remoteness of agricultural fields from economic centers on production costs in the Republic of Bashkortostan
Authors:   Land Management Department at Federal State Budgetary Educational Institution of Higher Education ", Volkov S. N. ,   GUZ",   , Russian Academy of Sciences, Mamedova E. E. ,   Land Management Department of Federal State Budgetary Educational Institution of Higher Education GUZ, Akhmetkuzhina A. D. ,   Department of Interaction with the Federal Assembly and the Government of the Russian Federation for Legislative Activities of the Department of Normative-Legal Regulation in the Field of Land Relations and Real Estate Circulation of Rosreestr
Published: February 2024

The article examines the impact of the remoteness of agricultural fields from economic centers on the production costs of cultivating agricultural crops. The methodology for determining the cost of production and its elements in fields of crop rotation with different technological properties is considered in this paper. The article also contains the coefficients of cost change depending on the distances of cargo transportation, which makes it possible to make scientifically based land management decisions. The calculation of the effectiveness indicators was carried out by example of the agricultural production cooperative "Krasnaya Bashkiriya", the Republic of Bashkortostan.
Sustainable development of agriculture as a factor of ensuring food security of the country
Authors:   Organization of Agricultural Production and Industrial Economics Department State University of Land Use Planning, Moscow, Sagaidak A. A.
Published: February 2024

The article examines the issues of ensuring the sustainable development of the agricultural sphere by increasing the fertility of agricultural lands and returning them in agricultural sphere, as well as the application of innovations as the foundation of food security. The author evaluates the results of the implementation of state support programs and proposes the measures to improve the economic regulation in the agricultural sector.
The land administration methods implemented in the strategy of spatial development of the Russian Federation
Authors:   Land Management and Cadastre Department, Saratov State University of Genetics, Biotechnology and Engineering named by N.I. Vavilov", Gagina I. S. ,   , Saratov
Published: February 2024

In 2019, the Government of the Russian Federation approved the Spatial Development Strategy of the Russian Federation for the period until 2025, which content is quite extensive. However, the developing mechanisms for implementation are still unclear. In author’s opinion, the spatial development of the country is closely related to the use of land, therefore land administration methods can become the main mechanism in the implementation of the Strategy. The article discusses the content of the Spatial Development Strategy of the Russian Federation for the period until 2025, including the main goals, objectives and spatial objects. The author also proposes the land administration methods in accordance with the goals and objectives of the Strategy.
Creation of 3D landscape in AutoCAD Civil 3D according to data from MapInfo
Authors:   Department of Informatics, Federal State Educational Institution of Higher Education ", Kalinova E. V. ,   State University of Land Management,",   Moscow, Dmitrieva E. E. ,   Department of Informatics, Federal State Educational Institution of Higher Education "State University of Land Management," Moscow
Published: February 2024

The article presents the technology of constructing a 3D model of landscape in AutoCAD Civil 3D based on data from Mapinfo. The source material is a raster cadastral map. The resulting 3D model of landscape and visualization options are presented in this work.
Using geospatial data for solving problems of territorial planning by example of Krasnodar
Authors:   Cadastre and Geoinformation Engineering Department, Kuban State Technological University, Krasnodar, Osennyaya A. V. , Gura D. A. ,   Cadastre and Geoinformation Engineering Department at Krasnodar State Technical University, Geodesy Department at Kuban State Agrarian University named after I.T. Trubilin, Krasnodar, Samarin S. V. ,   Information Systems and Programming Department, Kuban State Technological University, Krasnodar, Tovkach V. S. ,   Cadastre and Geoinformation Engineering Department, Kuban State Technological University, Krasnodar
Published: February 2024

The goal of this study was to develop a structure of geospatial data for solving problems of territorial planning by example of Krasnodar. For this purpose, the tasks of territorial planning were analyzed, the problems of the existing provision of territorial planning were identified, and the geospatial data, their applications and advantages were considered here. In conclusion, the main elements of the geospatial data cloud were selected by analyzing the tasks of the departments of Krasnodar in the field of territorial planning.
Tenapanor as Therapy for Hyperphosphatemia in Maintenance Dialysis Patients: Results from the OPTIMIZE Study
Authors: Sprague Stuart M. , Weiner Daniel E. , Tietjen David P. , Pergola Pablo E. , Fishbane Steven , Block Geoffrey A. , Silva Arnold L. , Fadem Stephen Z. , Lynn Robert I. , Fadda George , Pagliaro Lynae , Zhao Suling , Edelstein Susan , Spiegel David M. , Rosenbaum David P.
Published: February 2024

Key Points

Tenapanor, a first-in-class local inhibitor of sodium/hydrogen exchanger isoform 3, acts as a phosphate absorption inhibitor by decreasing paracellular phosphate absorption.

Tenapanor alone or with phosphate binders achieved P ≤ 5.5 mg/dl over 10 weeks in 34%–38% of patients taking phosphate binders at baseline.

Tenapanor can help adults with CKD on maintenance dialysis achieve normal serum phosphate concentrations.

Background

OPTIMIZE was a randomized, open-label study evaluating different tenapanor initiation methods. OPTIMIZE evaluated tenapanor alone and in combination with phosphate binders (PBs) to achieve target serum phosphate (P) ≤5.5 mg/dl.

Methods

Patients with inadequately controlled P receiving maintenance dialysis from 42 US locations who were taking PBs with baseline P > 5.5 mg/dl and ≤ 10.0 mg/dl, or were PB-naive with baseline P > 4.5 mg/dl and ≤ 10.0 mg/dl, were included in OPTIMIZE. Participants taking PBs at baseline were randomized to switch from PBs to tenapanor (Straight Switch; n=151) or reduce PB dosage by ≥50% and add tenapanor (Binder Reduction; n=152); PB-naive patients started tenapanor alone (Binder-Naive; n=30). Participants received tenapanor 30 mg twice a day for 10 weeks (part A), followed by an elective, 16-week open-label extension (part B). Outcomes included changes from baseline in P, intact fibroblast growth factor 23, parathyroid hormone, serum calcium, and medication burden; patient-reported outcomes; and safety.

Results

By part A end point, 34.4% (Straight Switch), 38.2% (Binder Reduction), and 63.3% (Binder-Naive) of patients achieved P ≤ 5.5 mg/dl. Mean P reduction and median pill burden reduction from baseline to part A end point were 0.91±1.7 mg/dl and 4 pills/d for the Straight Switch and 0.99±1.8 mg/dl and 1 pill/d for the Binder Reduction group. The mean P reduction for Binder-Naive patients was 0.87±1.5 mg/dl. Among Straight Switch and Binder Reduction patients who completed patient experience questionnaires, 205 of 243 (84.4%) reported an improved phosphate management routine. Diarrhea was the most common adverse event (133 of 333 [39.9%]).

Conclusions

Tenapanor as monotherapy or in combination with PBs effectively lowered P toward the target range in patients who were PB-naive or who were not at goal despite PB use.

Clinical Trial registration number

NCT04549597.
Сurrent state and prospects of the Sakhalin balneological potential in rehabilitation and health resort treatment
Authors: Antonyuk M. V. , Gvozdenko T. A. , Lebedev S. V. , Chelnokova B. I.
Published: February 2024

Aim. To assess the prospects for the use of mineral waters and therapeutic muds (peloids) of the Sakhalin region for treatment and prophylactic purposes on the basis of their balneological properties.

Materials and methods. The results of balneological analyses of mineral waters and therapeutic muds of the island areas of the Sakhalin region and regulatory documents were used.

Results. The mineral waters and therapeutic muds of the Sakhalin region as its major therapeutic resources are characterized. The main groups of mineral waters for internal and external use include siliceous thermal, iodobromic, arsenic, and boric waters. It is noted that unique deposits of Sakhalin-type mineral waters, such as acidic waters with a high content of metals, petroleum products, and organic substances, require additional research. The Sakhalin region is rich in all available types of therapeutic muds– silt sulﬁde, mound, peat, and sapropel.

Conclusion. The Sakhalin region possesses a wide variety of balneological resources for health resort treatment and rehabilitation. Among them are the deposits of mineral waters and therapeutic muds that are promising for research and use in medical and wellness organizations.
Efficacy of functional electrical stimulation of the lower extremities in stroke patients
Authors: Kantur T. A. , Khmeleva E. V. , Kolesnikova Yu. B. , Barzeeva Z. B.
Published: February 2024

Aim. To evaluate the eﬃcacy of functional electrical stimulation of the lower extremities in stroke patients at diﬀerent stages of motor rehabilitation.

Materials and methods. The study involved 80 patients with motor disorders after stroke. The studied treatment methods included passive and passive-active functional electrical stimulation (FES) in combination with the THERATrainer Tigo and active FES (neuro-orthosis) WalkAide.

Results. The analysis of motor status indicators, namely the Berg Balance Scale, 6-minute walk test, and dynamic walking index showed the maximum eﬃcacy of active FES with biofeedback.

Conclusion. When prescribing and selecting a method of electrical stimulation, preference in neurorehabilitation should be given to methods of passive-active and active functional stimulation.
Сombined rehabilitation after COVID-19 coronavirus infection
Authors: Yubitskaya N. S. , Yurenko A. V. , Kos`yanenko N. G. , Mineeva E. E.
Published: February 2024

Aim. To study the eﬃcacy of personalized combined rehabilitation of PCS patients in the setting of a day hospital.

Materials and methods. The study involved 68 patients with PCS (49 women and 19 men) aged from 36 to 76 years. Bronchial asthma (BA) was detected in 26 patients, chronic obstructive pulmonary disease (COPD)– in 9 patients, and stage II hypertension– in 12 patients. Depending on severity of PCS, the treatment program included drug therapy and physiotherapeutic treatment. The rehabilitation course lasted for 14 days. The eﬃcacy of medical rehabilitation was assessed by the dynamics of clinical and functional indicators.

Results. After the rehabilitation course, asthenic syndrome decreased in all patients. The majority of patients reported improvement in dyspnea according to the mMRC scale. In COPD patients, the CAT test score decreased by 26%. After rehabilitation, the asthma patients showed a decrease in the ACQ test score by 45%, with the peakﬂowmetry indicators having improved. Improvements in spirometry and peripheral oxygen saturation of capillary blood were recorded.

Conclusion. Personalized medical rehabilitation of patients after coronavirus infection can reduce the severity of PCS signs. The rehabilitation methods used contributed to the restoration of external respiratory function, stabilization of the patients’ emotional state, reduction of shortness of breath, hypoxemia, and other impaired functions in patients after COVID-19.
Training program for primary care physicians in medical rehabilitation at the Pacifi c Medical University
Authors: Kuzmina T. N. , Kuznetsova G. V. , Petrova L. Ya.
Published: February 2024

This article describes the experience of training primary care physicians in the ﬁeld of medical rehabilitation. The existing procedure for the arrangement of medical rehabilitation prescribes its rules and order of implementation in medical primary health care organizations both in outpatient and day patient settings. The Paciﬁc State Medical University (PSMU) runs training programs for primary care physicians within the 31.05.01 educational program “General Medicine”, direction “02 Healthcare”. In accordance with the curriculum, a training program “Medical Rehabilitation” that includes both lectures and training sessions was developed. This program is aimed at forming the necessary competencies of future primary care physicians in implementing and monitoring the eﬀectiveness of the patient’s medical rehabilitation. Training is carried out at the facilities of the PSMU Institute of Clinical Neurology and Rehabilitation Medicine by specialists having experience in medical rehabilitation and having completed the program “Modern aspects of specialist training in the ﬁeld of physical and rehabilitation medicine”.
Capabilities of Neuroimaging in Determining the Role of Metabolic Pathway of Neurodegeneration in the Pathophysiology of Glaucoma
Authors: Рожко А.А.
Published: February 2024

Глаукома является мультифакторным нейродегенеративным заболеванием глаз и головного мозга. В статье описана роль энергетического метаболизма сетчатки и метаболических путей транссинаптической нейродегенерации в патофизиологии глаукомы. Выполнен обзор научных результатов структурных и функциональных методов нейровизуализации у пациентов с глаукомой. Описаны морфометрические изменения высоты и объема латеральных коленчатых тел, уменьшение белого и серого ве- щества в зрительной коре и повреждения в других областях головного мозга. Также оценены результаты функциональных связей головного мозга при различных стадиях заболевания и их корреляции со структурными изменениями. Особое внимание уделено метаболическим исследованиям путем количественного определения биохимических соединений с помощью протонной магнитно-резонансной спектроскопии и позитронно-эмиссионной томографии (ПЭТ), анализ которых показал, что на настоящий момент их результаты являются противоречивыми и разнородными. Неизвестно, являются ли выявленные паттерны снижения скорости церебрального метаболизма глюкозы патогномоничными для глаукомы, поэтому актуальны будущие исследования метаболизма нейроцитов при глаукоме с применением ПЭТ.

Glaucoma is a multifactorial neurodegenerative disease of the eyes and brain. The article describes the role of retinal energy metabolism and transsynaptic neurodegeneration metabolic pathways in the pathophysiology of glaucoma. Review of scientific results of structural and functional neuroimaging methods in patients with glaucoma was performed. Morphometric changes in height and volume of the lateral geniculate body, a decrease in white and gray matter in the visual cortex, and damage in other areas of the brain described. The results of functional connections of the brain at various stages of disease and their correlation with structural changes were also assessed. Particular attention is paid to metabolic studies through the quantification of biochemical compounds using proton magnetic resonance spectroscopy and positron emission tomography (PET), the analysis of which has shown that the results are currently contradictory and heterogeneous. It is not known whether the observed patterns of decreased cerebral glucose metabolic rate are pathognomonic for glaucoma, so future PET studies of metabolism in glaucoma are relevant.
Repensando la participación comunitaria
Authors: Francés García Francisco , Barros González Marta , Falck Andrés , Pérez-Gañán Rocío , Enríquez Sahsil , Ortega Fernández Javier , Martínez Moreno Alicia
Published: February 2024

La evolución del presupuesto participativo constituye un tema clave de estudio dado que es una de las innovaciones participativas de más larga trayectoria y de mayor expansión en los últimos veinte años a lo largo del mundo. Asimismo, España es territorio que se presta a la observación de los cambios en el presupuesto participativo, dado que fue uno de los países donde desarrolló con fuerza cuando comenzó a impulsarse en Europa. El objetivo del presente estudio es conocer las experiencias de presupuesto participativo en la actualidad en España, en términos del marco institucional de los procesos, las reglas de participación y los roles y posibilidades de acción ciudadana en las mismas. Para ello, se trabaja con datos de 297 presupuestos participativos municipales. Los resultados muestran una expansión notable del presupuesto participativo, aunque la vida media de las experiencias sigue siendo corta. Los presupuestos participativos presentan nuevas características en relación con estudios anteriores:  la diversificación de las metodologías empleadas, el reducido peso de la participación ciudadana en su diseño o el intensivo componente digital. También se identifican rasgos de continuidad, como la condición vinculante de las decisiones ciudadanas o la necesidad del cumplimiento de determinados requisitos administrativos para poder tomar parte.
Evaluasi Transformasi Good Corporate Governance pada Bank Aceh Syariah
Authors: Gunawan Fajar , Maulina Rina
Published: February 2024

The Islamic banking sector has experienced significant development, offering various Sharia-compliant products such as Islamic savings, Sharia-based accounts, and Sharia deposits, emphasizing the need for a robust implementation of good corporate governance. This study aims to differentiate the disparities in applying good corporate governance at Bank Aceh Syariah before and after its conversion. This qualitative descriptive research focuses on Good Corporate Governance at Bank Aceh Syariah, utilizing secondary data such as the company's annual reports from the periods 2014-2015 (conventional) and 2018-2022 (Sharia). The results of the GCG self-assessment at Bank Aceh Syariah for the years 2014-2015 in the conventional operational system had an average GCG score of 1.86, which was better compared to the period of 2018-2022 in the Sharia operational system with an average GCG score of 1.90. This indicates that the implementation of Good Corporate Governance at Bank Aceh during conventional operations was superior compared to operations in the Sharia system. Post-conversion to the Sharia system, there is an additional organizational structure in the implementation of Good Corporate Governance with the establishment of a Sharia Supervisory Board, responsible for overseeing the bank's business activities aligned with the Fatwa of the National Sharia Council.
Práctica de mecanizado 2: torneado
Authors: Urban Petr , Astacio López Raquel , Ternero Fernández Fátima Ángela , Cintas Físico Jesús , Montes Martos Juan Manuel
Published: February 2024

El torneado es un proceso de mecanizado utilizado en la fabricación de piezas cilíndricas y cónicas, mediante la eliminación de material de una pieza de trabajo que gira sobre su eje. Este proceso se realiza mediante una máquina denominada torno, que sujeta y gira la pieza mientras una herramienta de corte elimina el exceso de material para darle forma. En este recurso didáctico se explican las diferentes partes del torno, los movimientos de la pieza y de la cuchilla para mecanizar una pieza (rotación, avance y penetración), los diferentes tipos de cuchillas que se pueden utilizar para el corte (cuchilla enteriza, cuchilla con placa soldada y cuchilla con placa intercambiable) y las operaciones más importantes del torneado (refrentado, cilindrado, achaflanado, ranurado y roscado). Además, se explica detalladamente, como tornear una rosca métrica. Por último, se fabrica una pieza desde cero aplicando los conocimientos adquiridos a lo largo de este vídeo didáctico. Finalmente, queremos expresar nuestro agradecimiento a Juan Manuel Jaramillo Pareja por su apoyo en el taller.
HKUST-1 formation in solution influenced by laser-induced plasma at the early stage
Authors: Chiba Shota , Kanno Moriyuki , Muneoka Hitoshi , Ito Tsuyohito , Terashima Kazuo
Published: February 2024

A suspension containing the raw materials of HKUST-1, which is a metal-organic framework, is irradiated by a nanosecond-pulsed laser at 532 nm to generate plasma only at the early stage (5–30 min) of the formation process. Depending on the plasma treatment conditions, HKUST-1 begins forming after the laser-induced plasma generation is stopped. The formation of HKUST-1 can be represented by the Gualtieri model, thus suggesting that the plasma treatment only at the early stage influences the formation process by modifying the nucleation and growth rates.
Stacked structure dependence on resistive switching characteristics in sumanene molecular memory
Authors: Kawai Ryoichi , Ashihara Eito , Ishikawa Ryousuke , Mitani Yuichiro
Published: February 2024

Nonvolatile memories using molecule (molecule memories) are attracting attention. This is because these materials are suitable for miniaturization and higher capacity of memories in terms of their properties and dimensions. We have already demonstrated that the metal–insulator–metal (MIM) devices with sumanene-inserted bilayer graphene show huge resistive switching characteristics. However, the reason why resistive switching occurs in the graphene/sumanene/graphene structure has yet to be clarified. In this work, to investigate the mechanisms of the resistive switching phenomenon in sumanene-inserted bilayer graphene, plural kinds of stacked MIM structures are fabricated and evaluated. As a result, the measurement results clearly show that the graphene/sumanene/graphene structure is indispensable in the resistive switching phenomenon. Furthermore, based on the temperature dependence of the resistive switching, it is confirmed that a significant I
ON/I
OFF ratio can be obtained at higher operation temperatures.
PELATIHAN LITERASI KEBANGSAAN DAN KEUANGAN SERTA BERFIKIR KOMPUTASI BAGI ANAK-ANAK PEKERJA MIGRAN DI SANGGAR BIMBINGAN SENTUL KUALA LUMPUR
Authors: Suhendra Beni , Setiadi Tedy , Ratih Rina
Published: February 2024

Anak-anak pekerja migran Indonesia (PMI) di Kuala Lumpur, Malaysia, merupakan kelompok yang memerlukan perhatian khusus dalam persiapan masa depan mereka. Minimnya akses pendidikan, rendahnya pengetahuan kebangsaan, kurangnya perlindungan hukum, isolasi sosial, keterbatasan akses informasi merupakan masalah kompleks yang dihadapi. Pengabdian masyarakat ini bertujuan meningkatkan literasi kebangsaan, literasi keuangan dan berfikir komputasi guna bekal mereka hidup di luar negari dan di era informasi ini.

Metode pelaksanaan menggunakan model pembelajaran berbasis Joyful Learning,orientasi materi literasi kebangsaan menumbuhkan cinta tanah air dengan sastra puisi lagu kebangsaan Indonesia,  literasi keuangan memotivasi dan melatih membuat rencana kegiatan keuangan, sedangkan berfikir komputasi mengasah kemampuan dengan berlatih soal-soal yang berkaitan dengan IT untuk bekal di era informasi ini dan sebagian besar peserta merespon positif keseluruhan pelatihan ini.

Berdasar hasil evaluasi, kegiatan pengabdian ini dipandang berhasil karena mendapat respon positif dari anak-anak pekerja migran dengan  terjadi  peningkatan pemahaman dan kemampuan dari setiap peserta untuk ketiga materi pelatihan.
O REGIME PATRIMONIAL DO CASAMENTO
Authors: JESUS EVERALDO ANTÔNIO DE , SANTOS JOSÉ ROBERTO P DOS
Published: February 2024

O Brasil contempla institutos diversos para a terminação da sociedade conjugal, ou seja, o divórcio e a separação judicial, ao lado de outras causas, tais a morte de um dos cônjuges e a nulidade ou anulação do casamento, sendo que o casamento válido, por sua vez, somente se dissolve pela morte de um dos cônjuges ou pelo divórcio - que deve ser precedido de separação judicial por mais de um ano ou comprovada separação de fato por mais de dois anos. É a separação judicial que põe fim, de logo, ao regime matrimonial de bens, como também aos deveres de coabitação e fidelidade recíproca, como se o casamento fosse dissolvido, embora não habilite, imediatamente, 2os ex-cônjuges, a contraírem novo casamento, o que será possível somente com o divórcio.
DATA DRIVEN NA GOVERNANÇA CORPORATIVA
Authors: Sacramento Jaison da Silva
Published: February 2024

A ação de governar é uma característica bem antiga na cultura da humanidade, voltando nos primórdios da raça humana, é possível visualizar em nossa história, diversas formas de governos nas civilizações ocidentais e orientais existentes naquela época. O uso de uma governança corporativa em conjunto com uma estratégia orientada a dados, permite aos executivos do negócio uma maior facilidade no processo de tomada de decisão empresarial. A inteligência de negócio dar uma maior sensibilidade aos tomadores de decisão, através da sinergia de soluções e tecnologias que são competitivas e permitem uma visão holística na condução de uma estratégia de governança que pode ser alcançado através de um planejamento contábil e financeiro, estruturado em uma cultura orientada a dados. Essa ação deve fazer parte da estrutura executiva do negócio, não pode ser apenas uma ação isolada nesse ou naquele departamento, todos devem estar cientes da missão e valores da empresa, que tem como pilar uma visão estruturada nos princípios da governança empresarial, demonstrando uma maior sensibilidade para definir estratégias que se identifiquem com a cultura da organização e permita que decisões sejam tomadas de forma rápida e sustentadas por informações relevantes para atender o mercado em geral. A implementação de boas práticas para atender aos princípios da governança corporativa na área financeira de uma organização, somente é uma ação viável quando implementado os processos e políticas internas que permitam o êxito nas ações de auditoria que devem ser executadas por comitê interno e externo a organização.
القيادة الرقمية كمدخل لمعالجة البدانة التنظيمية وفقا لبيئة العمل الالكتروني
Authors: فاضل سهيله محمد
Published: February 2024

يهدف هذا البحث للتعرف على دور القيادة الرقمية في معالجة البدانة التنظيمية وفقا لبيئة العمل الالكتروني،

وتمثل ميدان البحث بالجامعات العراقية وتم اختيار عينة من 80 شخصا من ضمن الاداريين والفنيين العاملين في الجامعات في بغداد ، تم الحصول على 71 استمارة كان من بينها 66 استمارة صالحة للتحليل الاحصائي بنسبة استرداد بلغت (88.75%). تم صياغة انموذج الدراسة وتحليله باعتماد معاملات الارتباط والانحدار والنمذجة الهيكلية بواسطة برنامجي AMOS v.23 و SPSS v.23. وتوصل البحث الى مجموعة استنتاجات اهمها ان الانتقال الى بيئة العمل الالكتروني يدعم التأثير الايجابي للقيادة الرقمية في معالجة البدانة التنظيمية للمنظمات والمؤسسات العراقية.
RESEARCH AND ANALYSIS OF THE ORIGIN OF CRACKS ON THE SURFACE OF ROLLING STOCK WHEEL PAIRS
Authors:   Doctor of technical science, professor., Head of department «Wagons and rolling stock»  Tashkent railway transport engineering Institute, Fayzibayev Sh. S. , Валиев Ш. М. ,   PhD., associate professor, Deputy dean of faculty «Electromechanical»  Tashkent railway transport engineering Institute, Samborskaya N. A. ,   Senior researcher  laboratory «Materials science and welding»
Published: February 2024

The article proposes the models and analytical dependences for assessing the impact interactions of the surface layers of the material of the ridges of tyres with the rail parts in curved track sections and turnouts on curved surfaces of contact, which, in turn, create the conditions for the destruction of the wheel surface effected by tensions.