bluuebunny/crossref_metadata_2025 huggingface dataset:
Simultaneous Interdisciplinary Teamwork on Digital Twins in a 3D Collaborative Environment
Authors: Beisheim Nicolai , Rädle Matthias , Reichwald Julian , Linde Markus , Ott Tobias , Amann Sebastian , Kastner Kevin
Published: November 2022

Digital twins of product and production processes are being used more and more frequently. The reason for this are the benefits for all departments involved. Therefore, it is not only important to share an IT platform as a 3D collaboration environment with uniform data structures, so all employees can work with the same database. As well it is important to give all interdisciplinary departments the opportunity to work in a common simulation and interact with it as a digital twin of the product and production process. Each department must be enabled to add their information, to collaboratively design a working digital twin of the real product. In addition, it must be possible for several people to work together simultaneously in a shared virtual environment. Voice chat, video chat and graphic simulation features such as virtual and augmented reality must be integrated to enable collaboration and interaction with the digital twin. Another challenge is to allow multiple participants to take part in these virtual meetings simultaneously, even if they use different end devices. The paper presents a 3D collaboration environment developed in research projects based on the development environment for graphic simulations Unity3D, with the ability to include various user concepts and functions for the specialist departments and allows access for the employees as a multi-user application on different end devices.
Management of Cancer Patients in the COVID-19 Crisis Using Telemedicine: A Systematic Review
Authors: Salehi Fatemeh , Mashhadi Leila , Khazeni Kamran , Ebrahimi Zahra
Published: November 2022

Background: Telemedicine can provide a solution for disease management during the COVID-19 pandemic. This literature review aims to explore the role of telemedicine during the COVID-19 pandemic for management of cancer patients. Method: A comprehensive systematic search was conducted in PubMed, Science Direct, EMBASE, and Web of Science databases for the papers published until April 2021. Studies were included in case they had practically used telemedicine in the management of cancer patients during the COVID-19 crisis. Results: After screening 2614 titles and abstracts and reviewing 305 full-texts, 16 studies were found to be eligible. The results indicated that most of the patients contacted by telemedicine services mostly used to intract with patients breast cancer (n=4, 25%). The most common use of telemedicine was the provision of virtual visit services (n=10, 62.25%). Besides, communication was most frequently provided by live video conferences (n=11, 68.75%). Conclusion: Telemedicine can provide continued access to necessary health services in oncology care and serve as an important role in pandemic planning and response.
An Overview on Security and Privacy of Data in IoMT Devices: Performance Metrics, Merits, Demerits, and Challenges
Authors: Khatiwada Pankaj , Yang Bian
Published: November 2022

The Internet of Medical Things (IoMT) emerges with new trendsetter device applications, where it defines the incorporation of medical devices with the Internet of Things (IoT). The healthcare sector continues to encounter challenging obstacles that have an impact on the quality of treatment provided to patients. To get rid of this problem, IoMT is being deployed to achieve the high reliability and efficiency of the health system. The IoMT devices are superimposed with clinical information as they contain the details of patient health data, address, and other patient identifiers. By containing such amount of sensitive information, it becomes cumbersome to preserve data privacy and security. Due to inadequate security and privacy precautions, patient health data is susceptible to leakage, which has a direct impact on the patient’s life. In addition, the majority of medical devices are susceptible to cyberattacks, putting patient information at risk. Inadequate control of life-support equipment can have a devastating effect on patient outcomes. Thus, this survey intends to review the various security models of IoMT devices using standard techniques to support health care systems. It provides a wide range of literature reviews regarding IoMT systems and compares them with traditional methodologies. This review work exhibits the motivation for current technologies to maintain the security and privacy of patients’ data with IoMT devices. The systematic review entails background on security in IoMT devices, techniques for security, usage of diverse validation measures, and also discusses the problems and motivation for future research work.
ETL Processes for Integrating Healthcare Data – Tools and Architecture Patterns
Authors: Cheng Ka Yung , Pazmino Santiago , Schreiweis Björn
Published: November 2022

Improving the interoperability of healthcare information systems is a crucial clinical care issue involving disparate but coexisting information systems. However, healthcare organizations are also facing the dilemma of choosing the right ETL tool and architecture pattern as data warehouse enterprises. This article gives an overview of current ETL tools for healthcare data integration. In addition, we demonstrate three ETL processes for clinical data integration using different ETL tools and architecture patterns, which map data from various data sources (e.g. MEONA and ORBIS) to diverse standards (e.g. FHIR and openEHR). Depending on the project’s technical requirements, we choose our ETL tool and software architecture pattern to boost team efficiency.
A Bibliometric Analysis of the Trends in the Research on Wearable Technologies for Cardiovascular Diseases
Authors: Kpadjouda Job Ginette E.A. , Degila Jules , Ahouandjinou S. Arnaud R.M. , Houndji Vinasetan R. , Ba M. Lamine
Published: November 2022

In this paper, a bibliometric analysis of research on wearable technologies for cardiovascular diseases was conducted with Bibliometrix and based on 1675 papers collected in Scopus from 2000 to 2022, and interesting results were presented. The US and China stood out for their sustained productivity in the field of cardiovascular diseases. The examination of the authors’ keywords revealed that between 2000-01 and 2009-12, “Respiration” and “personalized applications” were the most popular research topics, however from 2010-01 to 2019-12, attention was given to “ECG,” “Wearable devices,” “Wearable sensors,” and “heart rate”. This study suggests that in the present decade, researchers should focus on topics related to artificial intelligence, hypertension, ECG, wearable sensors, and African countries must address their technological gap in the coming years.
Reporte de Mercados Financieros - primer trimestre de 2016
Authors: Vargas Hernando , Cardozo Pamela , Benítez Sandra , Rojas Juan Sebastián , Cardozo Nathali , Martínez Diego Alejandro , Moreno José Fernando , Patiño Lina , Venegas Tatiana , Vergara Daniel Ricardo , Galvis Ana María
Published: November 2022

El Banco de la República (BR) genera información para la toma de decisiones, la rendición de cuentas y la difusión al público. En particular, el Reporte de Mercados Financieros está enmarcado dentro del principio de difusión al público y contribuye a cumplir con el servicio que presta el Banco de ofrecer información e investigación económica de calidad.
Reporte de Mercados Financieros - segundo trimestre de 2015
Authors: Vargas Hernando , Cardozo Pamela , Benítez Sandra , Rojas Juan Sebastián , Cardozo Nathali , Martínez Diego Alejandro , Moreno José Fernando , Patiño Lina , Rassa Juan Sebastián , Venegas Tatiana , Pinzón Juliana , González Bryan Stiven
Published: November 2022

El Banco de la República (BR) genera información para la toma de decisiones, la rendición de cuentas y la difusión al público. En particular, el Reporte de Mercados Financieros está enmarcado dentro del principio de difusión al público y contribuye a cumplir con el servicio que presta el Banco de ofrecer información e investigación económica de calidad.
Reporte de Mercados Financieros - segundo trimestre de 2016
Authors: Vargas Hernando , Cardozo Pamela , Benítez Sandra , Rojas Juan Sebastián , Martínez Diego Alejandro , Mendoza Andrés Mauricio , Moreno José Fernando , Patiño Lina , Reyes María Fernanda , Venegas Tatiana , Vergara Daniel Ricardo , Roberto Vargas Valeria
Published: November 2022

El Banco de la República (BR) genera información para la toma de decisiones, la rendición de cuentas y la difusión al público. En particular, el Reporte de Mercados Financieros está enmarcado dentro del principio de difusión al público y contribuye a cumplir con el servicio que presta el Banco de ofrecer información e investigación económica de calidad.
Reporte de Mercados Financieros - cuarto trimestre de 2013
Authors: Vargas Hernando , Cardozo Pamela , Benítez Sandra , Rojas Juan Sebastián , Cardozo Nathali , Martínez Diego Alejandro , Moreno José Fernando , Patiño Lina , Rassa Juan Sebastián , Venegas Tatiana
Published: November 2022

El Banco de la República (BR) genera información para la toma de decisiones, la rendición de cuentas y la difusión al público. En particular, el Reporte de Mercados Financieros está enmarcado dentro del principio de difusión al público y contribuye a cumplir con el servicio que presta el Banco de ofrecer información e investigación económica de calidad.
Sexual dimorphism of body dimensions variability in connection with ecological factors in infant period of ontogenesis
Authors:   Lomonosov Moscow State University, Anuchin Research Institute and Museum of Anthropology, Mokhovaya st., 11, Moscow, 125009, Russia, Gorbacheva Anna K. , Fedotova Tatiana K. ,   Lomonosov Moscow State University, Anuchin Research Institute and Museum of Anthropology, Mokhovaya st., 11, Moscow, 125009, Russia
Published: November 2022

Introduction. Dynamics of sexual dimorphism, SD, of 4 main anthropometric dimensions of 12 months old children in connection with different exogenous factors is under discussion. Materials and methods. The object of the investigation is SD variability of height, weight, chest and head girths of 12-months-old children 50 urban groups examined in 1960th-1970th are analysed. Data is borrowed from textbooks on physical development, published by Research Institute of Hygiene and Health of Children and Adolescents (1962, 1965, 1977 years). The quantitative estimation of the value of SD is based on Kullback divergence. The exogenous factors block includes different anthropogenic factors (water pollution level, air pollution, population density etc.) and climatic factors (geographical latitude of locality as characteristic of daylight duration and partly insolation level, difference between minimal and maximal year temperature values, minimal temperature of January). The estimation of direction and level of associations between somatic parameters SD and ecological factors was held using correlation analysis. Program package Statistica 10 was applied. Results. The preliminary factor analysis of considered exogenous factors extracted 4 factors, covering 79% of variability of ecological niche parameters in total. Dominant role of population size as characteristic of urban ecological niche was shown. Correlations of somatic dimensions SD of 12-months-old children with most significant ecological parameters, selected by means of factor analysis, were insignificant, but evaluation of their direction for different pairs of characteristic reveals, that for SD of height and weight associations with exogenous factors are negative, for SD of girths – are positive. Hence such body parameters as height and weight are more ecosensitive for girls, while head and chest girths for boys. The dominant role of population size characteristic in somatic variability of 1-year-old children is proved by changing of direction of correlations between SD levels and such factors as water and air pollution when megalopolises are excluded from the sample sets. Conclusion. The main result of the study is different by sex phenotype plasticity of somatic parameters in infancy. It has been revealed also that somatic status of urban samples of 1970th is associated mainly with population size.
Formulation and Evaluation of Cream Turmeric Extract Preparations from Turmeric Rhizomes (Curcuma domestica Val.)
Authors: Estefania Kaban Vera , Silalahi Jansen , Sumaiyah Sumaiyah , Satria Denny
Published: November 2022

The use of plants as a method of herbal treatment is a step that is currently being developed by many researchers to produce effective and minimal side effects. Turmeric is one of the most widely used cooking spices by the people of Indonesia. The main ingredients possessed by turmeric include curcumin (77%), demethoxy (17%) and bisdemethoxy (3%). One of the pharmaceutical preparations with a topical delivery system is a cream preparation which is a semi-solid dosage form, containing one or more drug ingredients dissolved or dispersed in an appropriate base material. Turmeric can be formulated in various preparations, one of which is a cream dosage form. The advantage of using cream preparations is that they are practical, easy to wash and clean. The purpose of this study was to formulate turmeric extract in a cream preparation. The results of the evaluation test showed that the formula produced a cream with a yellow-orange color, a characteristic odor of turmeric, and a preparation with a semisolid cream texture, had good homogeneity, good dispersing ability, the pH of the preparation was 5.84; 6.32; 6.24; 5,94;5,94 and the type of emulsion is O/W (Oil in Water).
Calcium Silicate As A Media For Enhancement of Vitamin E Concentration from Candlenut Oil (Aleurites moluccana)
Authors: Sebayang Firman
Published: November 2022

Vitamin E consists of two parts, namely tocopherol and tocotrienol which are found as minor components in candlenut oil. The process of increasing vitamin E concentrate in candlenut oil aims to obtain higher vitamin E levels from candlenut oil through a major and minor component separation with adsorption and desorption methods with three types of calcium silicate hydrate adsorbent namely calcium silicate with 90% absolute ethanol (Ca-S 90), calcium silicate with 75% absolute ethanol (Ca-S 75) and calcium silicate synthesized from CaO (Ca-S). The three adsorbents were synthesized by hydrothermal method at 170ºC for 24 hours accompanied by stirring and characterized by XRD, SEM-EDX, and BET. Furthermore, the adsorbent was applied to enrich vitamin E concentrate in candlenut oil through the adsorption process using a glass column with a mass ratio between candlenut oil and adsorbent that was 1:1, then the vitamin E desorption process was carried out by adding n-hexane solvent. Vitamin E levels obtained after the adsorption and desorption process were for Ca-S 75 adsorbent was 764.41 ppm (1. 82 times enriched), for Ca-S 90 adsorbent was 1011.29 ppm (2. 40 times enriched) and for Ca-S adsorbent was 1029, 38 ppm (2.4 5 times enriched) from the initial vitamin E level in candle nut oil was 420.66 ppm. Ca-S adsorbent showed the best vitamin E enrichment.
Job insecurity and emotional exhaustion on turnover intention of health workers in Islamic Hospital Purwokerto
Authors: Rohmawati Antin , Dwiyanti Retno , Nur'aeni  , Faisal Hamzah Imam
Published: November 2022

Turnover intention often occurs in the working environment. In some companies, the turnover rate can be quite high. It can be affected by the existence of job insecurity and emotional exhaustion. The research method employed a quantitative approach, with the number of 125 health workers as the respondents. The study aimed to determine the effect of job insecurity and emotional exhaustion on turnover intention. The analysis revealed a significant effect of job insecurity and emotional exhaustion on the turnover intention 30.7% and the remaining 69.3% were other factors beyond the study. The lower the job insecurity and emotional exhaustion are, the lower the turnover intention.
Turnover intention sering kali terjadi dilingkungan pekerjaan. Pada beberapa perusahaan tingkat turnover dapat dikatakan cukup tinggi. Hal tersebut dapat dipengaruhi oleh adanya job insecurity dan emotional exhaustion. Metode penelitian yang digunakan yaitu pendekatan kuantitatif dengan jumlah responden 125 tenaga kesehatan. Penelitian ini menggunakan skala job insecurity, emotional exhaustion dan turnover intention. Dari hasil analisis menunjukkan bahwa terdapat pengaruh yang signifikan pada job insecurity dan emotional exhaustion terhadap turnover intention 30.7% dan sisanya sebesar 69.3% merupakan faktor lain di luar penelitian. Semakin rendah job insecurity dan emotional exhaustion maka turnover intention semakin rendah
Condições de autocuidado relacionado à saúde sexual de puérperas adolescentes: revisão integrativa
Authors: Serrano Anna Karolyne Soares
Published: November 2022

A adolescência, segundo o Estatuto da Criança e do Adolescente, corresponde ao período da vida entre os 12 e 18 anos, é considerado um momento de descoberta que ocasiona um período de instabilidade emocional. Quanto mais cedo é a iniciação sexual, maior é a chance de ocorrer uma gravidez indesejada. Após o nascimento da criança, ocorre o puerpério, nessa fase a jovem passa por muitas adaptações físicas e emocionais. Dessa forma, a questão norteadora deste estudo é: O que a literatura científica aborda sobre as condições de autocuidado relacionado à saúde sexual de puérperas adolescentes? Sendo assim, o trabalho optou por estudos seletivos ao aspecto de educação sexual e reprodutiva de adolescentes e o autocuidado no período puerperal. O objetivo geral deste foi analisar na literatura científica as condições de autocuidado relacionado à saúde sexual das puérperas adolescentes. Trata-se de uma revisão integrativa de literatura nas seguintes bases de dados: Base de dados bibliográfica especializada na área de Enfermagem (BDENF), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), e Sistema Online de Busca e Análise de Literatura Médica (MEDLINE). Para ter acesso a estas bases utilizou-se a Biblioteca Virtual em Saúde Pública (BVS), no período de agosto a setembro de 2021. Fizeram parte dessa pesquisa 10 artigos, que permitiram compreender a necessidade de ações de promoção a saúde para o autocuidado relacionado à saúde sexual das puérperas adolescentes. Evidencia-se, na literatura científica, além do desconhecimento das puérperas adolescentes sobre as condições de autocuidado referente à sua saúde sexual, como também a necessidade de ter mais pesquisas científicas sobre o assunto. Ao considerar a necessidade de aprimorar o conhecimento das adolescentes a respeito da saúde sexual, ressalta-se a pertinência da realização de atividades educativas a respeito da promoção da saúde sexual e reprodutiva. Destaca-se, entre os principais desafios encontrados pelas adolescentes no puerpério, o desconhecimento e despreparo para vivenciar uma mudança tão drástica em suas vidas.
Report on the European BioEco observing system
Authors: Ratnarajah Lavenia , Hesplop Emma , Lips Inga , Simpson Pauline , Nordlund Lina M. , Unsworth Richard , Sousa-Pinto Isabel , Benedetti-Cecchi Lisandro
Published: November 2022

This deliverable provides (1) updates to D1.2 ‘Map the current state of biological observations in Europe’, (2) a report on the two workshops and global review undertaken to progress capacity and coordination of ocean observation, and (3) outlines key steps forward that will improve our capacity to predict biological and ecosystem changes under a changing climate.
Macro-Programmable Reconfigurable Stream Processor for Collaborative Multi-Agent Systems
Authors: Geurkov Vadim , Kirischian Valeri , Chun Pill Woo , Kirischian Lev
Published: November 2022

 

Growing demand for high speed processing of streamed data (e.g. video-streams, digital signal streams, communication streams, etc.) in the advanced manufacturing environments requires the adequate cost-efficient stream-processing platforms. Platforms based on the embedded microprocessors often cannot satisfy performance requirements due to limitations associated with the sequential nature of data execution process. During the last decade, development and prototyping of the above embedded platforms has started moving towards utilization of the Field Programmable Gate Array (FPGA) devices. However, the programming of an application to the FPGA based platform became an issue due to relatively complicated hardware design process. The paper presents an approach which allows simplification of the application programming process by utilization of: (i) the uniformed FPGA platform with the dynamically reconfigurable architecture, (ii) a programming technique based on a temporal partitioning of the application in segments which can be described in terms of macro-operators (function specific virtual components). The paper describes the concept of the approach, presents the analytical investigation and experimental verification of the cost-effectiveness of the proposed platform comparing to the platforms based on sequential micro-processors. It is also shown that the approach can be beneficially utilized in collaborative design and manufacturing.

 
The Implementation of Multigrade Policy in Probolinggo Regency: Challenges and Program Sustainability
Authors: Novianti Vita , Dafik  , Dina suryawati  , Supranoto
Published: November 2022

Multigrade is one alternative solution to solve education problems caused by the lack of teachers, unequal distribution of teachers, and lack of students in every learning group. These problems need a particular policy regulated by the government because education is right for every citizen. This research explored the overview of program success, challenges, and the potency of multigrade sustainability. The research methodology employed was descriptive qualitative, which was collected through observation, interview, and documentation. The result is analyzed, interpreted, and verified. A case study approach was conducted considering the multigrade policy is only applied in certain areas with particular conditions. Research is organized in Probolinggo Regency, East Java. Research revealed multigrade policy is appraised properly to resolve the teacher shortage problem and a minimum number of students in each study group. However, there are still big challenges to the sustainability of multigrade policy. As a result, multigrade programs can not be applied systematically in other regencies which have similar problems.
SOSIALISASI STRATEGI PEMBELAJARAN DALAM JARINGAN (DARING) SELAMA MASA ADAPTASI KEBIASAAN BARU BAGI CALON MAHASISWA
Authors: Susmini  , Oktaviani Eva , Feri Jhon , Wijaya Sapondra , Soewito Bambang
Published: November 2022

Pandemi COVID-19 telah memaksa lembaga pendidikan baik sekolah maupun perguruan tinggi mengubah metode pembelajaran dari tatap muka (offline) menjadi dalam jaringan/daring (online). Sistem pembelajaran daring ini, peran guru atau dosen digantikan oleh orang tua. Hal ini tentu menimbulkan berbagai hambatan kultural di tengah masyarakat. Hambatan-hambatan tersebut tentu harus dicarikan solusinya, mengingat pandemi COVID-19 belum bisa diprediksi kapan akan berakhir. Adaptasi model pembelajaran harus terus dilakukan oleh satuan pendidikan. Oleh karena itu, upaya promosi kesehatan mengenai bagaimana meminimalkan dampak penggunaan perangkat lunak komputer atau hand phone selama pembelajaran daring perlu disosialisasikan sejak dini terutama pada mahasiswa baru yang memasuki dunia pendidikan perguruan tinggi. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk memberikan gambaran bagi mahasiswa baru dalam mengenal strategi metode pembelajaran daring selama masa adaptasi kehidupan baru dan meminimalkan dampaknya. Metode dilakukan secara virtual dihadiri oleh calon mahasiswa baru Prodi Keperawatan Lubuklinggau berjumlah 76 orang, orang tua mahasiswa, dan dosen. Adanya peningkatan nilai rerata pre dan posttest setelah diberikan sosialissasi materi yaitu 13,12 menjadi 18,28. Institusi pendidikan hendaknya memodifikasi metode pembelajaran selama masa pandemi dengan tetap memperhatikan capaian mata kuliah
PEMAHAMAN IBU HAMIL TRIMESTER III TENTANG TANDA-TANDA PERSALINAN MELALUI BUKU KIA DI KLINIK PRATAMA TANJUNG TAHUN 2022
Authors: Parapat Friska Margareth , Siregar Ronni Naudur , Haslin Sharfina
Published: November 2022

Salah satu faktor yang mempengaruhi prevalensi kematian ibu dan bayi adalah kualitas pelayanan kesehatan ibu dan anak (KIA). Menurut hasil penelitian Riskesdas 2013, buku KIA saat ini belum digunakan secara ideal, dengan ibu yang memiliki buku KIA (80,8%) tetapi dapat menunjukkan tenaga kesehatan (40,4%) melebihi jumlah ibu yang tidak memiliki buku KIA (19,2 %). Klinik Pratama Tanjung adalah klinik yang rata-rata dikunjungi 50- 100 orang per bulan. Tujuan dari pengabdian kepada masyarakat ini adalah untuk mengetahui lebih jauh bagaimana ibu hamil di Puskesmas Deli Tua menggunakan buku KIA. Jika dimanfaatkan secara efektif oleh tenaga kesehatan dan ibu hamil, Buku Kesehatan Ibu dan Anak (KIA) menawarkan informasi kesehatan sebagai upaya pemerintah untuk meningkatkan pemahaman dan perilaku sehat ibu dan anak. Banyak ibu hamil dan keluarganya yang masih belum memahami atau memanfaatkan nasehat kesehatan yang diberikan dalam buku Kesehatan Ibu dan Anak (KIA). Penelitian ini menggunakan desain deskriptif kuantitatif. Metode penelitian yang digunakan dalam penelitian ini yaitu: Purposive sampling, dimana dengan jumlah sampel sebanyak 55 responden. Kuesioner digunakan sebagai alat ukur dalam penelitian ini, dan data dianalisis menggunakan analisis univariat. Hasil rangkuman penggunaan buku KIA oleh ibu hamil di Klinik Pratama Tanjung berdasarkan 55 responden (100%) dan penggunaan informasi kesehatan sebanyak 55 responden Kesimpulan: Penggunaan buku KIA oleh ibu hamil di Klinik Pratama Tanjung  sudah 70% persen baik dalam hal penggunaan dan konsumsi informasi kesehatan tentang persiapan persalinan.
 
Kata kunci: Pemahaman, ibu hamil trimester III, tanda-tanda persalinan, buku Kesehatan Ibu dan Anak
PENYULUHAN PELAKSANAAN TEKNIK BIRTH BALL TERHADAP KEMAJUAN PERSALINAN PADA IBU BERSALIN KALA I FASE AKTIF
Authors: Haslin Sharfina , Simanjuntak Eva Hotmaria , Simanjuntak Netti Meilani
Published: November 2022

Salah satu komplikasi persalinan yang ikut menyumbang dalam angka kematian ibu adalah persalinan lama. Persalinan lama merupakan persalinan yang berlangsung lebih dari 24 jam dan jika tidak ditangani dengan cepat dan tepat akan mengakibatkan ibu mengalami infeksi, kehabisan tenaga sebelum bayi dilahirkan, dehidrasi, kadang dapat terjadi pendarahan. Salah satu upaya dalam mencegah persalinan lama seperti pelvic rocking dengan birthing ball yang mendukung persalinan agar dapat berjalan secara fisiologis. Tujuan pengabdian masyrakat ini adalah untuk membantu mengurasi waktu persalinan kala I. Birth ball dilakukan dengan cara duduk di atas birth ball dan dibantu oleh petugas kesehatan atau keluarga. Pelaksanaan pengabdian masyarakat ini berlangsung selama 7 hari di Klinik Pratama Tanjung. Kegiatan ini diawali dengan melakukan pemeriksaan tanda-tanda vital, lalu diikuti edukasi mengenai pemanfaatan dan cara penggunaan birth ball. Pelaksanaan penyuluhan dilakukan pada 4 orang ibu bersalin kala I, seluruh responden mengalami kemajuan persalinan dan merasa adanya penurunan rasa nyeri pada pinggang.
PENINGKATAN PENGETAHUAN MASYARAKAT MELALUI EDUKASI VAKSINASI COVID-19 DI BENGKULU
Authors: Dahrizal Dahrizal , Septiyanti Septiyanti
Published: November 2022

Di Indonesia, 34 propinsi terdeteksi positif Covid-19 sehingga seluruh Provinsi di Indonesia Zona Merah Covid-19, dan lebih dari 200 kabupaten di Indonesia telah ditemukan penderita terinfeksi Covid-19.  Jumlah Orang terinfeksi virus Covid-19 di Indonesia terus bertambah. Tertanggal 20 April 2020 mencapai angka 6760 kasus positif covid-19. Penambahan kasus positif terus terjadi demikian juga penambahan kematian yang mencapai 590 pasien (covid19.go.id). Akibat peningkatan jumlah kasus positif covid-19 dan kematian akibat terinfeksi covid-19, Presiden Republik Indonesia mengeluarkan Keputusan Presiden RI No.11 tahun 2020 tentang penetapan kedaruratan kesehatan masyarakat Corona virus disease 2019 (Covid-19) pada tanggal 31 Maret 2020. Perkembangan Covid-19 yang sangat progresif ini menyebabkan perlukan tindakan nyata sebagai upaya pengabdian masyarakan untuk menurunkan kasus tersebut.
Kegiatan ini bertujuan untuk menginformasikan kepada masyarakat edukasi terkait pencegahan penularan Covid-19 yang nantinya diharapkan dapat meningkatkan kepedulian masyarakat dalam mencegah dan memberantas Covid-19. Selain itu pengabdian masyarakat ini diharapkan memberikan dampak positif mengenai perilaku Hidup Bersih pada masyarakat.
Pelaksanaan kegiatan pengabdian kepada masyarakat Poltekkes Kemenkes Bengkulu bersamaan dengan kegiatan praktik kerja lapangan terpadu (PKLT) oleh mahasiswa Diploma Tingkat III dan Sarjana Terapan Tingkat IV berjumlah 13 orang di Kecamatan Sungai Serut, Kota Bengkulu. Kerja sama dan kolaborasi yang baik antar profesi kesehatan sangat dibutuhkan untuk meningkatkan kepuasan masyarakat dalam memperoleh layanan kesehatan. Metode yang digunakan dalam pengabdian masyarakat adalah edukasi-sosialisasi melalui berbagai media yaitu leaflet, poster, video, dan sebagainya yang berkaitan dengan pencegahan penularan Covid-19, isolasi diri dan peningkatan sistem imun tubuh.
Hasil pengabdian masyarakat didapatkan bahwa, telah terbentuk gugus tugas relawan Covid-19 di Kecamatan Sungai Serut, Kota Bengkulu. Masyarakat telah diberikan berbagai informasi dan edukasi terkait pencegahan Covid-19, cara isolasi mandiri, dan peningkatan sistem imun tubuh kepada sejumlah masyarakat termasuk pasien ODP, PDP, OTG.
Pelaksanaan Senam Hamil dalam Upaya Persiapan Menjelang Persalinan
Authors: Maiseptya Sari Ruri Maiseptya Sari , Fahriani Metha , Aprilia Ningsih Dewi Aprilia Ningsih , Fitriani Desi , Elvira Silviani Yulita
Published: November 2022

Abstrak
 
Salah satu penyebab kematian ibu adalah partus lama (5%). Partus lama merupakan salah satu dari beberapa penyebab kematian ibu dan bayi baru lahir. Partus lama adalah persalinan yang berlangsung lebih dari 18 jam yang dimulai dari tanda-tanda persalinan. Partus lama akan menyebabkan infeksi, kehabisan tenaga, dehidrasi pada ibu, kadang dapat terjadi infeksi, cedera dan asfiksia yang dapat meningkatkan kematian bayi. Angka kematian ibu di dunia berdasarkan data WHO didapatkan bahwa dalam setiap menit seseorang perempuan meninggal karena komplikasi yang terkait dengan proses kehamilan dan persalinannya. Senam hamil adalah salah satu kegiatan olahraga yang dapat dilakukan ibu selama kehamilan. Tujuan pengabdian masyarakat ini adalah meningkatkan pengetahuan ibu hamil tentang senam hamil dan mengajarkan senam hamil. Sasaran pengabdian masyarakat adalah 25 ibu hamil di Bidan Praktik Susi Irma Novia Kota Bengkulu. Pengabdian ini diawali dengan penyuluhan kesehatan tentang senam hamil kemudian dilanjutkan dengan praktek senam hamil. Hasil dari pengabdian masyarakat terjadi peningkatan pengetahuan sebesar 48% dari sebelum dilakukan penyuluhan dengan sesudah diberikan penyuluhan. Ibu hamil juga mampu mempraktekkan senam hamil dengan benar.  
 
Kata Kunci: Pengetahuan, Pelaksanaan senam hamill
Effektive Verfahrenshilfe-Verteidigung im Österreichischen Strafverfahren
Authors: Hofer Marlene
Published: November 2022

Entspricht die österreichische Rechtslage der Judikatur des EGMR und der RL-PKH? Dieses Buch widmet sich der Thematik der effektiven Verfahrenshilfeverteidigung im österreichischen Strafverfahren. Die Monografie ist hierfür in zwei Teile untergliedert. Im ersten Teil werden die grundrechtlichen und internationalen Vorgaben hinsichtlich des einer beschuldigten Person zukommenden Rechts auf Verfahrenshilfe erläutert. Das Hauptaugenmerk in diesem ersten Teil liegt auf der im Zusammenhang mit der gegenständlichen Thematik ergangenen Judikatur des EGMR. Der zweite Teil der Monografie ist der Verfahrenshilfeverteidigung im österreichischen Strafverfahren gewidmet. In Anknüpfung an die Rechtsprechung des EGMR und die Untersuchungsergebnisse des ersten Teils wird vor allem der zentralen Frage nachgegangen, in welchen konkreten Fällen die österreichischen Höchstgerichte bisher das Vorliegen einer unwirksamen Verteidigung der beschuldigten Person durch eine oder einen ihr bestellten Verteidiger*in angenommen haben und ob aus der Rechtsprechung des EGMR ein Reformbedarf der österreichischen Rechtsordnung resultiert.
Services Provided Through Community Clinic: Access and Utilization by Rural People
Authors: Hossain Sarowat , Alam SM Rowshan , Islam Mahabubul , Miah Shah Shahjada , Hanifa Md Abu , Sarker Zakir Hossain , Fatema Taslim , Begum Munira , Hasan Labib
Published: November 2022

Background: Community clinics (CC) have been restarted in 2009 by the government of Bangladesh through a project called “Revitalization of Community Health Care Initiatives in Bangladesh” (RCHCIB) to accomplish the ambitious project of establishing 18,000 community clinics. Since then 10,723 Community clinics have been established and they provide free health and family planning services to rural people (for every 6000 population one CC).

Objective: The study aimed to assess the prevalence of access and utilization of services provided through community clinics by rural people.

Methods: This cross-sectional descriptive study was conducted in Palashbari, Gaibandha district from 15th March 2019 to 20th April 2019. 568 respondents were selected conveniently from the catchment area of 6 community clinics (CCs). Data were collected by face-to-face interviews with a pretested structured questionnaire.

Results: Among 568 respondents, majority ware in the age group of 31-50 years (45.4%),female (83%) and housewives (76.8%).93.5% of the respondents visited community clinics. And 85.6% were benefited from the community clinic service. Maternal and child health service utilization was poor (pregnancy registration 27.6%, ANC and PNC 45.2%, family planning services 49.3%) and there is no normal delivery service in the community clinic. 66.2% of the respondents availed EPI Services, 45.8% received Health Education, 65.3% received Vitamin-A Supplementation, 59.9% availed Child Care Services, 71.7% received Treatment of Minor Illness and Diseases, 17.4% availed Referral Services.

Conclusion: The CCs are well located in terms of access. According to the Respondents' services provided by the community, the clinic was average. Maternal and child health services, pregnancy, and birth registration were below the mark. There is no normal delivery service and according to the respondent’s opinion referral system was also poor.

J Rang Med Col. September 2022; Vol. 7, No. 2:20-24
Contribution to the knowledge of Polypores (Agaricomycetes) in the Amazonian Forest, with 16 new records for the state of Pará, Brazil
Authors: Couceiro Douglas de Moraes , Soares Adriene Mayra Silva , Couceiro Sheyla Regina Marques
Published: November 2022

We present an inventory of polypore fungi (Basidiomycota; Hymenochaetales and Polyporales) with the aim of knowing the diversity of an area of 8 km2 of Brazilian Amazon rainforest, in the surroundings of HPP Sílvio Braga, in the west of Pará, where 91 species were collected (545 specimens), with 16 of these new records for the state of Pará, and 1 for America. These numbers tend to increase, given the projected occurrence of 118 species for the area. 87 species were considered occasional or rare, with only four considered frequent and none abundant. The richness observed in the study area was similar to other conservation units in the Amazon, for example, Caxiuanã National Forest (74 species). This observation, added to the potential increase in the number of species, the number of species with low representativeness (relative frequency) and the number of new records for the state, demonstrate the need to expand studies on polypore fungi in the region to learn about their biodiversity and the need for conservation of that area.
Multidisciplinary Approach to Management and Care of Patients with Type 2 Diabetes Mellitus
Authors: Bain Steve , Cummings Michael H. , McKay Gerard A.
Published: November 2022

The management of adults with Type 2 diabetes mellitus (T2DM) was traditionally delivered in a single specialist setting with a focus on glycaemic control. As the treatment landscape evolved to consider the need to prevent cardiovascular disease and/or microvascular complications, so did the requirement to manage this complex multisystem condition by multiple healthcare providers in both primary care and specialist settings. This article discusses the key studies that changed the way T2DM is managed to incorporate an interdisciplinary approach to care, the principles of the multidisciplinary teams, examples of multidisciplinary teams in real-world clinical practice, and associated patient outcomes.
Engineering mesophilic GH11 xylanase from Cellulomonas flavigena by rational design of N-terminus substitution
Authors: Tian Wenzhuo , Zhang Ziyang , Yang Cuiping , Li Piwu , Xiao Jing , Wang Ruiming , Du Peng , Li Nan , Wang Junqing
Published: November 2022

Xylanase, a glycoside hydrolase, is widely used in the food, papermaking, and textile industries; however, most xylanases are inactive at high temperatures. In this study, a xylanase gene, CFXyl3, was cloned from Cellulomonas flavigena and expressed in Escherichia coli BL21 (DE3). To improve the thermostability of xylanase, four hybrid xylanases with enhanced thermostability (designated EcsXyl1–4) were engineered from CFXyl3, guided by primary and 3D structure analyses. The optimal temperature of CFXyl3 was improved by replacing its N-terminus with the corresponding area of SyXyn11P, a xylanase that belongs to the hyperthermostable GH11 family. The optimal temperatures of the hybrid xylanases EcsXyl1–4 were 60, 60, 65, and 85°C, respectively. The optimal temperature of EcsXyl4 was 30 C higher than that of CFXyl3 (55°C) and its melting temperature was 34.5°C higher than that of CFXyl3. After the hydrolysis of beechwood xylan, the main hydrolysates were xylotetraose, xylotriose, and xylobiose; thus, these hybrid xylanases could be applied to prebiotic xylooligosaccharide manufacturing.
Polycomb subunit Pcgf2 mediates ovulation and fertility through transcriptional regulation progesterone receptor
Authors: Wang Yibo , Wang Wenji , Cheng Kaixin , Geng Kaiying , Liang Jing , Wang Peike , Zhang Jiawei , Niu Shudong , Jia Longzhong , Zhang Shuo , Li Lingyu , Feng Xiean , Wang Chao , Wang Haibin , Zhang Hua , Zhang Yan
Published: November 2022

Ovarian follicles are the fundamental structure to support oocyte development, which provides mature oocytes for offspring. This process requires granulosa cells (GCs) to respond to the midcycle surge of hormones, leading to GC proliferation and differentiation by a series of genes’ transcriptional expression changes. Epigenetic mediator, Polycomb Repressive Complex 1 (PRC1) has been reported to function in fetal ovarian development. However, its functional relevance to folliculogenesis and ovulation remains unknown. In this study, we demonstrated that GC-selective depletion of PCGF2, a key component of PRC1, led to the loss of follicles, ovulation defects, and a lengthened estrus cycle, resulting in subfertility in female mice. The expression of PCGF2 is in the GCs of growing follicles and increases after human chorionic gonadotropin (hCG) stimulation. PCGF2 bound to the promoter of the key ovulation gene progesterone receptor (Pgr) and upregulated the expression of Pgr by targeting the epigenetic modification of H2AK119ub1 after hCG surge. Consistently, the expression of downstream genes of Pgr also sharply decreased, which resulted in the follicular rupture failed and oocyte entrapped in corpus luteum in GC-specific Pcgf2 knockout mice. Together, our study identified that PCGF2 is essential for folliculogenesis and ovulation via modulating hormone receptor expression.
Ionic liquids as electrolytes in aluminum electrolysis
Authors: Wu Junshi , Xie Peng , Hao Wenbin , Lu Dong , Qi Ye , Mi Yongli
Published: November 2022

Herein, the characteristics, research progress, and application prospects of ionic liquid-based electrolytic aluminum deposition are reviewed and analyzed in comparison with the Hall–Héroult method. The reaction conditions and production procedures of this material are discussed alongside the problems ionic liquids face in the electrolytic aluminum industry. Ionic liquid-based electrolytic aluminum deposition realizes the electrolytic aluminum reaction at low temperatures, achieving a reaction energy consumption close to the theoretical minimum value. The reaction also avoids harmful CO2 or HF emissions, demonstrating a green and environmental-friendly approach to the production of electrolytic aluminum. In the future, in-depth work on the implementation of ionic liquid electrolytes should be carried out, establishing the necessary technical criteria and laying the foundation for the integration of this approach.
Discovery of novel inhibitors targeting nematode chitinase CeCht1: Virtual screening, biological evaluation, and molecular dynamics simulation
Authors: Shen Shengqiang , Ding Baokang , Jiang Xi , Yang Meiling , Yang Qing , Dong Lili
Published: November 2022

Plant-parasitic nematodes are a main limiting factor for worldwide agriculture. To reduce the global burden of nematode infections, chemical nematicides are still the most effective methods to manage nematodes. With the increasing resistance of nematodes, the development of new anti-nematicides drug is urgent. Nematode chitinases are found to play important roles in various physiological functions, such as larva moulting, hatching from eggshell, and host infection. Inhibition of nematode chitinase is considered a promising strategy for the development of eco-friendly nematicides. In this study, to develop novel nematode chitinase CeCht1 inhibitors, virtual screening of the ZINC database was performed using the pesticide-likeness rules, pharmacophore-based and docking-based approach in turn. Compounds HAU-4 and HAU-7 were identified as potent CeCht1 inhibitors with the IC50 values of 4.2 μM and 10.0 μM, respectively. Moreover, molecular dynamics simulations combined with binding free energy and free energy decomposition calculations were conducted to investigate the basis for the potency of the two inhibitors toward CeCht1. This work gives an insight into the future rational development of novel and potent nematode chitinase inhibitors.
Considerations in the design of animal infection pilot studies
Authors: Laws Thomas R. , Maishman Thomas C.
Published: November 2022

Ethical research with experimental systems (animals or humans) requires a rationale for the number of subjects to be included in a study. Standard methods for estimating sample size are not fit-for-purpose when the experimenter cannot predict the effect size/outcome with any certainty. These types of studies are often designated “pilot study”; however, there are few guidelines for sample size needed for a pilot study. Here we seek to address this issue. Concerning survival analysis it is noted that the experimenter can adjust the parameters of the experiment to improve the power. We propose that the experimenter needs to consider the “limit of interest” needed to represent an effect that the experimenter would be prepared to defend in terms of scientific or medical interest. Conventional power analysis is then used to estimate the n to deliver an alpha (false positive rate) of p < 0.2. This approach provides a balance that can inform a future study, demonstrate a strong effect or dismiss if no effect was observed. Where weight change or infection burden is considered, parametric analysis can be used. Here the main requirement for the pilot study is to establish a meaningful estimate of variability for subsequent power analysis. When considering the confidence intervals for standard deviations, it can be noted that a turning point is reached for n of four to six, beyond which we observe diminishing returns, suggesting that sample sizes should be greater than four. Finally, we discuss both the importance in statistical blocking and repeated measures in maximising the usefulness of the pilot study; and the importance of considering and outlining analysis techniques prior to performing the experiment. These findings are intended to be useful in the design of experiments in further prospective research.
Changes and significance of gut microbiota in children with focal epilepsy before and after treatment
Authors: Zhou Changci , Gong Shuaizheng , Xiang Shiting , Liang Lijuan , Hu Xia , Huang Ruiwen , Liao Zhenyu , Ma Ye , Xiao Zhenghui , Qiu Jun
Published: November 2022

Objective

To better understand the alterations in gut microbiota and metabolic pathways in children with focal epilepsy, and to further investigate the changes in the related gut microbiota and metabolic pathways in these children before and after treatment.

Methods

Ten patients with newly diagnosed focal epilepsy in Hunan Children’s Hospital from April, 2020 to October, 2020 were recruited into the case group. The case group was further divided into a pre-treatment subgroup and a post-treatment subgroup. Additionally, 14 healthy children of the same age were recruited into a control group. The microbial communities were analyzed using 16s rDNA sequencing data. Metastas and LEfSe were used to identify different bacteria between and within groups. The Kyoto Encyclopedia of Genes and Genomes database was used to KEGG enrichment analysis.

Results

There were significant differences in α diversity among the pre-treatment, post-treatment, and control groups. Besides, the differences in gut microbiota composition in 3 groups were identified by principal co-ordinates analysis (PCoA), which showed a similar composition of the pre-treatment and post-treatment subgroups. At the phyla level, the relative abundance of Actinobacteria in the pre-treatment subgroup was significantly higher than that in the control group, which decreased significantly after 3 months of treatment and showed no significant difference between the control group. In terms of the genus level, Escherichia/Shigella, Streptococcus, Collinsella, and Megamonas were enriched in the pre-treatment subgroup, while Faecalibacterium and Anaerostipes were enriched in the control group. The relative abundance of Escherichia/Shigella, Streptococcus, Collinsella, and Megamonas was reduced significantly after a three-month treatment. Despite some genera remaining significantly different between the post-treatment subgroup and control group, the number of significantly different genera decreased from 9 to 4 through treatment. Notably, we found that the carbohydrate metabolism, especially succinate, was related to focal epilepsy.

Conclusion

Children with focal epilepsy compared with healthy controls were associated with the statistically significant differences in the gut microbiota and carbohydrate metabolism. The differences were reduced and the carbohydrate metabolism improved after effective treatment. Our research may provide new directions for understanding the role of gut microbiota in the pathogenesis of focal epilepsy and better alternative treatments.