bluuebunny/crossref_metadata_2025 huggingface dataset:
DWI CAPACITY IN PROSTATE CANCER DIAGNOSING
Authors: Karakoishin K. , Zholdybay Zh. , Aynakulova A. , Toleshbaev D. , Muhit G. , Ayserbay Ye.
Published: July 2023

Relevance: Prostate cancer is one of the leading causes of cancer deaths in men worldwide. Transrectal ultrasound-guided (TRUS) prostate biopsy is the most important diagnostic step, without which a definitive diagnosis cannot be made. Despite this, TRUS-guided prostate biopsy has a high rate of false negatives and is often accompanied by various clinical complications. Multiparametric MRI (mpMRI) is now widely used in routine urological and oncological practice. An element of mpMRI is diffusion-weighted imaging (DWI), which is successfully used in detecting and localizing clinically significant prostate cancer.
The study aimed to evaluate the DWI capacity in diagnosing prostate cancer.
Methods: 52 patients, 48-86 years old, with suspected prostate cancer, underwent mpMRI. DWI sequences obtained using T2-weighted imaging (T2WI) were compared with each other and compared with the anatomical structure of the prostate. Suspicious prostate cancer sites were marked as regions of interest, for which an apparent diffusion coefficient (ADC) was calculated. A 12-point TRUS-guided biopsy confirmed the presence or absence of prostate cancer.
Results: When analyzing quantitative measurements, ADC showed low values for cancer in the central gland (transitional zone and central zone) – 0.610±0.157×10-3 mm2/s, p=0.0001, and for cancer in the peripheral zone – 0.651±0.228×10-3 mm2/s, p=0.0004, compared to normal tissue. It was found that the highest sensitivity value (87.5%) is typical for ADC central gland, and the lower value for ADC peripheral zone is 75%. The highest specificity value (90.9%) was observed in ADC peripheral zone, and a lower value in ADC central gland – was 84.1%.
Conclusion: DWI is an effective non-invasive method for detecting and localizing prostate cancer, providing a qualitative (visual) and quantitative assessment of prostate cancer.
EVALUATION OF THE EFFECTIVENESS OF NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER
Authors: Omar A. , Kabildina N. , Kruk E. , Telmanov A. , Kabildin Zh.
Published: July 2023

Relevance: Breast cancer is the most common cancer among women. Modern treatment of locally advanced breast cancer requires a multidisciplinary approach, including local treatment: surgical and radiotherapy, systemic treatment, and a wide range of medications. The importance of systemic therapy is to improve relapse-free survival based on the control of micrometastases with the potential to spread throughout the body.
Systemic therapy for operable breast cancer includes adjuvant therapy and neoadjuvant therapy. Hormone therapy, chemotherapy, and targeted therapy represent systemic therapy, which can be prescribed individually or in combination.
For the most effective breast cancer treatment, tumors are classified into subtypes depending on the expression of biological markers. The presence of expression of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and the rate at which tumor cells divide are determined by determining the Ki67.
It is known that neoadjuvant chemotherapy (NCT) has clinical significance in locally advanced and inoperable breast cancer. NCT increases the frequency of organ-preserving operations and the overall survival rate when a complete pathomorphological regression of the tumor (pCR) is achieved.
The study aimed to conduct a literature review of previously published publications on the effectiveness and expediency of neoadjuvant chemotherapy for breast cancer.
Methods: The search and analysis of scientific publications were carried out in the databases Web of Science, Pubmed, and Scopus for ten years, from 2013 to 2023. According to the search, about 3000 articles were found, and 39 sources were left during the selection according to the inclusion and exclusion criteria
Results: Efficiency of NСT depending on different immunophenotypes in breast cancer patients was established. Tumor response was assessed according to RECIST criteria. A complete pathological response was observed more often in more aggressive subtypes of breast cancer – Her2-positive and triple-negative cancer. The relationship between pCR and long-term outcomes – OS and DFS have also been established.
Conclusion: Neoadjuvant chemotherapy is a systemic treatment of breast cancer, the main purpose of which is to reduce the size of the tumor for the possibility of performing organ-preserving surgery, as well as to increase the overall and relapse-free survival rates. NCT allows for evaluating the effectiveness of therapy in vivo and using alternative treatment regimens without tu-mor response to the therapy.
ENDOCRINE TOXICITY OF IMMUNE CHECKPOINT INHIBITORS IN CLINICAL PRACTICE
Authors: Safina S. , Mukhamed’yarova G. , Dimitrieva V.
Published: July 2023

Relevance: Immunological control points significantly changed cancer therapy worldwide after a new class of inhibitor drugs was registered. Based on clinical studies, this type of treatment was associated with better survival in sensitive patients than cytostatic therapy. Checkpoint inhibitors exert their effect by regulating the immune response to malignant cells, blocking the usual inhibitory pathways of T-cell regulation. The receptors of cytotoxic T-lymphocytic antigen-4 (CTLA-4) and programmed cell death protein (PD-1) or its associated ligand (PD-L-1) are the target of inhibitors. CTLA-4 acts at an early stage of triggering an antigenic response, and PD-1 and PD-L-1 act by modulating interaction with peripheral tissue
However, treatment with checkpoint inhibitors (ICTs) is accompanied by a wide range of immune mediated adverse events associated with the activation of the immune system. Despite the positive effect on survival, side effects with endocrine effects were noted in about 10% of patients.
The study aimed to assess the incidence of immune mediated adverse events from the thyroid gland in clinical practice in patients with different localization of malignant tumors in the first and subsequent lines of therapy with checkpoint inhibitors.
Methods: The study utilized anamnestic, laboratory, and instrumental tests. Laboratory analysis included determining the blood levels of TSH, T3, T4, ACTH, and cortisol. Data analysis was carried out using the Microsoft Excel program.
Results: The frequency of development of immune mediated thyroiditis against the background of therapy with blockers of control points of the immune pathway in our observation was 29%. The debut of thyroid disorders was diagnosed in the first 12-16 weeks of therapy, beginning with hyperthyroidism against the background of thyroid destruction, followed by a transition to persistent hypothyroidism after 1-3 months.
Conclusion: When analyzing the safety profile of ICTs in patients in our study, immune mediated adverse reactions did not differ in frequency and spectrum from world practice. The spectrum of toxicity did not depend on the localization of the tumor. Early diagnosis of thyroid lesions necessary for optimal and effective treatment can be carried out using laboratory tests. Knowing the timing of the development of adverse events during ICT therapy allows timely diagnosing and correcting complications from the thyroid to continue effective therapy.
THE PROSPECTS AND CHALLENGES OF CRISPR/CAS9 GENE EDITING IN CANCER THERAPY: A LITERATURE REVIEW
Authors: ABDUSSADYK D. , BEISENOVA A.
Published: July 2023

Relevance: Cancer remains one of the leading causes of death in Kazakhstan, and CRISPR/Cas9 offers possible solutions to treat it. Clustered, regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) is a system bacteria use to cleave foreign in-vaders. This system has been considered promising for cancer therapeutics by allowing researchers to edit cancer cell genes.
The system requires more trials, so it is essential to raise awareness of this technique for stu-dents and potential investors and highlight the current challenges that could be research opportuni-ties for researchers.
The study aimed to analyze and provide up-to-date information from reputable scientific journals on the current use of the CRISPR/Cas9 system in cancer therapeutics for medical students and researchers. This research paper also highlights the challenges associated with implementing CRISPR/Cas9 in clinical settings for cancer therapeutics.
Methods: The scientific literature and databases (PubMed and the Nature Journal) were searched and analyzed using the CRISPR/Cas9 system in cancer therapy.
Results: The results of this research indicate that scientists should focus on improving the types and structure of the Cas protein as well as the delivery methods, including the non-viral deliv-ery methods (liposome-based particles, hybrid vectors, gold nanoparticles, and extracellular vesicles) to contribute to improving the current status of cancer therapeutics.
Conclusion: CRISPR/Cas9 is an important technique that is still fraught with challenges and should be turned into research opportunities. The current challenges include the form and structure of the Cas nuclease, the types of engineering (in vivo vs. ex vivo), and the varieties of delivery methods. Each delivery method type has pros and cons and requires further research. In particular, future studies should focus on non-viral vectors, such as liposome-based particles, extracellular vesi-cles, hybrid vesicles, and gold nanoparticles.
Formulation and Characterization of Oral Dispersible Tablet of Aprepitant
Authors: Shah Bhakti , Kotadiya Manisha , Sheth Zankhna , J. Bhatt Ravi
Published: July 2023

The oral route of drug administration is more common and convenient where tablets and capsules emerged as popular dosage form but many patients have dysphasia or difficulty in swallowing which is currently affecting 35% general population. Aprepitant is anti-emetic drug and used in the treatment of chemotherapy in cancer. Fast onset of action is required in this indication there for it was thought to prepare Oral Dispersible Tablet of Aprepitant which would help to avoid first pass metabolism and improve bioavailability also Aprepitant is insoluble in water so, to increase the solubility solid dispersion method (kneading method) was used. Here, Aprepitant ODT is prepared by direct compression method using Polyplasdone XL10 as superdisitegrant and optimized by 32 Full factorial design. Here, Polyplasdone XL10 (x1) and Mannitol(x2) is use as independent variable. while dependent variable are disintegration time and wetting time. Optimized formulation F8 batch showed drug content (98.41±0.91); disintegration time is (18.02±1.20) Wetting time (22.53±0.43). The formulation is stable at 40ºc/75% RH for 30days.
Preparation, Characterization and Optimization of Sustained Release Matrix Tablets of Repaglinide using Box–Behnken Design
Authors: Kumar Gupta Sanjay , Patra Sradhanjali
Published: July 2023

The aim of this investigation was to develop and optimize the Sustained release Matrix formulations of Repaglinide (RLD) using response surface methodology by employing a 3-factor, 3-level Box–Behnken statistical design. The independent variables studied were the amount of hydroxypropyl methylcellulose (HPMC K4M), Ethyl cellulose (EC) and PVP K30. The Swelling index (Y1), drug release at 8 hr and 12hr were the target responses. The response surface methodology and multiple response optimizations utilizing a polynomial equation were used to search for the optimal formulation with a specific release rate at different time intervals. The results showed that the effect of combination of HPMC K4M and EC was the most influencing factor on the drug release from ER matrix tablets. The mechanism of drug release from RLD Matrix tablets was dependent on the added amount of EC. Validation of the optimization technique demonstrated the reliability of the model. The optimized formulation containing 50mg of HPMC K4, 35mg of EC, and 30mg of PVP K30 was prepared according to the software determined levels. DSC and FTIR studies combined with the stability study of the optimized formulation proved the integrity of the developed formulation. The Box–Behnken experimental design facilitated the formulation and optimization of extended release hydrophilic matrix systems of RLD in a short period of time and with the fewest number of experiments. The optimized Matrix tablet of Repaglinide showed good pharmacokinetic result over conventional formulation.
Screening of Antimicrobial activity of Siddhar Agathiyar’s Polyherbal preparation
Authors: Princess Sulekha S. Mary , Pushkala V. Poorna
Published: July 2023

Introduction: Siddha system of medicine is one of the ancient traditional system of medicines, which was originated by Siddhars.Siddha practitioners successfully handle thirty-two internal as well as external form of medicines. Chooranam is one of the internal medicines in powder form. Kabasura Chooranam is a Siddha poly herbal formulation, taken from Agasthiyar Vaidhya Deva Ragasiyam - 4th part, which has been indicated for respiratory ailments. It contains equal proportions of herbal drugs such as Thippili (Pipper longum), Kadukkai (Terminalia chebula), Nelli Vatral (Phyllanthus emblicus) and Thandrikkai (Terminalia bellerica). Aim: The aim of this study was to evaluate the antibacterial activity of Kabasura Chooranam against various microorganisms such as Streptococcus, Staphylococcus, Psuedomonus, Escherichia coli and Proteus. Methods: The medicine was tested for antimicrobial activity using Muller Hinton agar (MHA) media by disc diffusion method. Result: The study revealed that the test drug has significant inhibiting activity against Streptococcus, Staphylococcus and Escherichia coli. The individual ingredients of Kabasura chooranam contains the following active principles like piperine, myrobalan, chebuinic acid, chebulagic acid, gallic acid, phenolic compounds, saponins, ascorpic acid, antraquinone glycoside, arjungenin and many other compounds which are responsible for its antimicrobial activity. Conclusion: The pharmacological activity of these plants could be a possible scientific source to obtain effective herbal medicines with antimicrobial potential to treat various infectious diseases.
Therapeutic Potential of Stingless bee Pollen: A Review
Authors: Budi Setyawan Annaas , Rao U.S Mahadeva , Mohd Sairazi Nur Shafika
Published: July 2023

Stingless bee pollen is bee pollen from stingless bee, mixture of bee salivary enzymes, regurgitated honey, fermented by native microbes during storage in cerumen pot. Stingless bees are a type of honey producers that commonly live in tropical countries. In regions such as South America, Australia, and Southeast Asia. Recently, stingless bee pollen is a widely used dietary supplement due to the benefits associated with the bioactive compounds it contains. Due to the wide range of phytochemicals (flavonoids, polyphenols, phytosterols, phenolic, carotenoids, glutathione, polyphenols, Mangiferonic acid, vit C, vit E) as well as enzymes and coenzymes contained in stingless bee pollen, it is expected to have health-promoting value. Promising reports on antioxidative, anti-inflammatory, anticarcinogenic, antimicrobial, antidiabetic and anti-allergenic functions that can alter or regulate the immune system potentials require long-term and large clinical cohort studies. Integrating all these data and findings into one manuscript could increase the commercial value of stingless bee pollen as food ingredients. This review will also highlight the utility of stingless bee pollen for their medicinal and therapeutic properties, some of which have yet to be discovered.
Prevalence of oral premalignant lesions in the area with the highest prevalence of gastrointestinal cancer
Authors: Haleh Zokaee  , Maedeh banki  , Amir Hossein Akbari Zahmati  , Gholamreza Roshandel
Published: July 2023

Objective: According to research conducted in Iran, from 141450 cases of reported cancer between 2003-2006, 1896 cases of oral and lip cancer have been reported. The timely and prompt diagnosis of this disease reduces mortality, increases longevity, reduces damage to adjacent structures, reduces financial costs, and unwanted side effects. The current study aimed to investigate the prevalence of oral premalignant lesions in the oral cavity and the factors related to it in Golestan province. Methods: In this descriptive-analytic cross-sectional study, 1900 Iranian subjects living in Golestan province, regardless of gender, aged 40 and above, participated voluntarily and randomly. Initially, a questionnaire containing demographic information, assessment of habits and risk factors was completed for each patient in an interview form, followed by oral examination on all patients. Statistical analysis of data was done by SPSS 22. Results: The mean age of these individuals was 49.5 ± 10.3 years and the highest premalignant lesions were observed in the age range of 70-80 years. Of the 1900 participants, 69 (3.6%) had pre-malignant lesions. Among the pre-malignant lesions, the prevalence of lichen planus was 49.28%, leukoplakia was 14.49%, and the suspected malignancy was 18.8%. In addition, there was a significant relationship between the use of tobacco with the development of pre-malignant lesions (p <0.01). Cigarette alone showed the highest association with the development of pre-malignant lesions. Conclusions: In this study, there was a significant relationship between risk factors such as age, ethnicity and smoking with the development of premalignant lesions in people. However, risk factors such as alcohol consumption and family history did not show a significant relationship.
Role of platelet-rich plasma in the treatment of rotator cuff tendinopathy
Authors: Velasquez Garcia Ausberto , Ingala Martini Liborio , Franco Abache Andres , Abdo Glen
Published: July 2023

Shoulder pain is a common musculoskeletal complaint, and rotator cuff (RC) pathologies are one of the main causes. The RC undergoes various tendinopathic and avascular changes during the aging process. Other degenerative changes affecting its healing potential make it an appealing target for biological agents. Platelet-rich plasma (PRP) has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators, and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle, ligaments, and tendinous cells. This review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical evidence. Due to the different characteristics and conflicting outcomes, clinicians should use PRP with moderate expectations until more consistent evidence is available. However, it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate healing. Its autologous origin makes it a safe treatment, and its characteristics make it a promising option for treating RC tendinopathy, but the efficacy has yet to be established.
Instrumented assisted soft tissue mobilization vs extracorporeal shock wave therapy in treatment of myofascial pain syndrome
Authors: Shamseldeen Nourhan Elsayed , Hegazy Mohammed Moustafa Aldosouki , Fayaz Nadia Abdalazeem , Mahmoud Nesreen Fawzy
Published: July 2023

Shoulder pain is a common musculoskeletal complaint, and rotator cuff (RC) pathologies are one of the main causes. The RC undergoes various tendinopathic and avascular changes during the aging process. Other degenerative changes affecting its healing potential make it an appealing target for biological agents. Platelet-rich plasma (PRP) has demonstrated the potential to deliver a high concentration of several growth factors and anti-inflammatory mediators, and its clinical use is mainly supported by experiments that demonstrated its positive effect on muscle, ligaments, and tendinous cells. This review aimed to specify the role of PRP and its future applications in RC tendinopathies based on the current clinical evidence. Due to the different characteristics and conflicting outcomes, clinicians should use PRP with moderate expectations until more consistent evidence is available. However, it is reasonable to consider PRP in patients with contraindications to corticosteroid injections or those with risk factors for inadequate healing. Its autologous origin makes it a safe treatment, and its characteristics make it a promising option for treating RC tendinopathy, but the efficacy has yet to be established.
A case of acute decompensated CCF with massive bilateral pleural effusion that required prolonged chest tube drainage in a tertiary facility in Nigeria
Authors: Ubogun Ogheneakpobor Efe  , Aigbe Fredrick Igben  , Oyiwe Oghenetega Georgina  , Agboro Wisdom Oghenekobiruo  , Odukudu God-dowell Oghenevwogaga
Published: July 2023

Heart failure with massive bilateral pleural effusion (over 2 liters) is a rare occurrence that is yet to be dispelled due to the dearth of information on the topic. The prevalence and mortality of CCF are rising. Clinical features of heart failure include dyspnea, orthopnea, fatigue, anorexia early satiety, pedal edema, abdominal distension/ascites, anorexia, nausea, elevated jugular venous pressure, displaced apex beat, crepitations, hepatomegaly, jaundice. Pleural effusion may complicate this picture and worsen the clinical state. Pleural effusion in heart failure is usually transudative, with pleural fluid parameters in keeping with the Light criteria. The case is that of a 59-year-old man with acute decompensated congestive cardiac failure 2⁰ to Dilated cardiomyopathy in NYHA class IV precipitated by poor drug adherence, complicated by massive bilateral pleural effusion. He required prolonged chest tube drainage and subsequently had good clinical improvement. This case report serves as a wake-up call that these essentially rare occurrences still exist and that the clinical judgment and expertise of the clinician will be tested on a daily basis.
Rezension von: Schild, Georg; Schindling, Anton (Hrsg.), Kriegserfahrungen
Authors: Wettengel Michael , Schild Georg , Schindling Anton
Published: July 2023

Georg Schild/Anton Schindling (Hg.): Kriegserfahrungen – Krieg und Gesellschaft in der Neuzeit. Neue Horizonte der Forschung (Krieg in der Geschichte 55). Paderborn: Ferdinand Schöningh Verlag 2009; 348 S., 36 Abb., geb., 39,90 EUR
Rezension von: Fabri, Felix, Tractatus de civitate Ulmensi
Authors: Petershagen Wolf-Henning , Fabri Felix
Published: July 2023

Felix Fabri O.P.: Tractatus de civitate Ulmensi / Traktat über die Stadt Ulm. Herausgegeben, übersetzt und kommentiert von Folker Reichert (Bibliotheca suevica 35). Konstanz: Edition Isele 2012; 435 S., geb., 25,00 EUR
Rezension von: Scholl, Christian, Die Judengemeinde der Reichsstadt Ulm im späten Mittelalter
Authors: Wettengel Michael , Scholl Christian
Published: July 2023

Christian Scholl: Die Judengemeinde der Reichsstadt Ulm im späten Mittelalter. Innerjüdische Verhältnisse und christlich-jüdische Beziehungen in süddeutschen Zusammenhängen (Forschungen zur Geschichte der Juden, Abteilung A 23). Hannover: Verlag Hahnsche Buchhandlung 2012; 451 S., geb., 4 Karten, 4 Abb., 49,00 EUR
Feasibility of alternative economic models for local development in the municipality of Ivinhema/MS
Authors: Oliveira José Marciel dos Santos de , Santos Vilker Augusto Masculi dos , Silveira Vítor Cardoso da , Eduardo Antonio Sérgio , Schotten Paulo César , Fachin Solange
Published: July 2023

The pandemic context faced at all levels of society (international, national, state and even municipal) made society hostage to restrictive measures implemented by the government, in its most diverse spheres. The object of this study was the municipality of Ivinhema/MS where these restrictive measures were also present, reflecting on the need to make alternative measures feasible for business and income generation. In this way, the objective of the study was to present viable alternatives of social economies for the local development of the municipality of Ivinhema/MS. The main theoretical constructs used as a basis were local development, creative economy, circular economy, social currency and, finally, the brief presentation of the municipality under analysis. The case studies show that the application of alternative economic models has great potential to promote improvement in terms of employment and income in the municipality, with social and economic benefits to the local and regional community.
The operationalization of health care networks for the elderly in Brazil and in the world: scoping review
Authors: Lopes Fernanda , Nicoli Esther , Oliveira Samara , Espírito Santo Tiago , Caldas Célia
Published: July 2023

Objective: To map the scientific evidence about care for elderly people with dementia in the context of health care networks. Method: Scope review based on the methodology proposed by the JBI, with 17 studies selected from PubMed, Web of Science, Scopus, CINAHL, Embase, Virtual Health Library and other sources. Results: The identified concepts were organized according to the following categories: Healthcare Network System network with the coordination of Primary Care; Permanent education - training of professionals for early detection and diagnosis of dementia; Care strategies for elderly people living in places with greater geographical distance; Transitional care - communication with Primary Care to ensure continuity of care; Financing of family care - remuneration of informal or family caregivers and Community network focused on long-term care. Conclusion: This review made it possible to reflect on the care provided to elderly people with dementia, especially those in more advanced stages of the disease, and points to the need for restructuring the healthcare network system in Brazil and in the world.
Pre-Raphaelite Paintings in Oliver Parker’s Adaptation of Oscar Wilde’s The Importance of Being Earnest
Authors: Péteri Éva
Published: July 2023

In Oliver Parker’s film adaptation (2002) of Oscar Wilde’s The Importance of Being Earnest (1895), Cecily’s fictional diary features two Victorian paintings: John Everett Millais’ The Knight Errant (1870) and John Melhuish Strudwick’s Acrasia (1888). In my paper, I would like to explore how these visual references contribute to the viewers’ understanding of the plot and the characters, and what is suggested by their application about the director’s view of the pictures themselves.
Dancing for Freedom in Ken Loach’s Jimmy’s Hall (2014)
Authors: Remport Eglantina
Published: July 2023

Ken Loach is best known for making films that address issues around poverty, social injustice, and the struggles of the powerless. Jimmy’s Hall is one such film, narrating the story of James Gralton. This paper discusses the ways in which Loach uses dancing as a metaphor for freedom from social, political, and religious oppression in the Ireland of the 1920s and 1930s.
IMPLEMENTASI PENJAMINAN MUTU PENDIDIKAN DALAM PERSPEKTIF ISLAM DI MADRASAH ALIYAH KOTA PALEMBANG
Authors: Marzal Marzal
Published: July 2023

Kualitas pendidikan menjadi faktor penting dalam mewujudkan kontribusi pendidikan dalam pembangunan Indonesia. Islam memandang mutu sebagai standar tinggi untuk dipenuhi dalam penyelenggaraan pendidikan. Madrasah Aliyah (MA) sebagai Lembaga pendidikan islam harus memiliki dan melaksanaan penjaminan mutu yang baik. Hal tersebut sangat menarik karena Madrasah Aliyah dominan mempelajari mata pelajaran agama islam dan mata pelajaran umum. Rumusan penelitian yaitu: 1) bagaimana perspektif mutu dalam pandangan islam yang diterapkan di Madrasah Aliyah di kota Palembang? 2) bagaimana mengelola Madrasah Aliyah yang bermutu dengan menerapkan nilai islam?. Metode penelitian adalah deskriftif kualitatif. Penelitian dilakukan di MA Kota Palembang. Informan penelitian adalah kepala madrasah. Data dikumpulkan dengan Teknik wawancara. Teknik analisis data menggunakan triangulasi Sumber. Data yang terkumpul dianalisis, direduksi dan selanjutnya dilakukan penarikan kesimpulan.  Kesimpulan dari penelitian yaitu: 1) mutu dalam perspektif islam yang diterapkan di MA Kota Palembang adalah standar nilai dari suatu program dan kegiatan yang dilakukan oleh institusi Pendidikan Madrasah Aliyah yang berorientasi utama pada nilaimanfaat dan kebaikan untuk lembaga dan juga masyarakat, 2) mengelola Madrasah Aliyah yang bermutu dengan menerapkan nilai islam dilakukan dengan merancang program-program yang langsung memberikan manfaatnyata kepada masyarakat, serta mampu menempatkan madrasah sebagai problem solving ditengah masalah dan kebutuhan masyarakat
Peranan NGO Sebagai Sistem Sokongan Pembangunan Keluarga Islam Golongan OKU Pendengaran: Satu Tinjauan Ringkas
Authors: Mohd Khalil Nur Dayana , Mohd Rapini Azizah , Dimon Zanariah , Bahari Nora’inan , Sholehuddin Nawal , Muhammad Hashim Nurhidayah
Published: July 2023

Penyertaan golongan OKU pendengaran dalam sebarang program berkaitan pembangunan kekeluargaan Islam adalah sangat terhad dan terbatas termasuk penyertaan mereka dalam kursus pra dan pasca perkahwinan disebabkan kurangnya kemudahan untuk menyertai program-program berkaitan. Komitmen dan penyertaaan OKU pendengaran dalam program-program tersebut banyak bergantung kepada inisiatif dan kerjasama pihak badan bukan kerajaan (NGO) sama ada NGO yang terlibat dengan OKU pendengaran secara langsung atau tidak langsung. Oleh yang demikian kajian ini bertujuan mengenalpasti peranan NGO sebagai sistem sokongan kekeluargaan Islam bagi golongan OKU pendengaran dan mengenalpasti NGO-NGO yang berperanan memberikan pendedahan atau program-program kekeluargaan kepada golongan OKU pendengaran. Kajian ini merupakan kajian kualitatif lapangan melibatkan metode pengumpulan data melalui perbincangan meja bulat (Round Table Discussion/RTD) melibatkan informan yang terdiri daripada wakil NGO OKU, ahli akademik, wakil Jabatan Agama Iskam Negeri-negeri, wakil Jabatan Kemajuan Islam Malaysia sebagai penggubal MBKPPI, wakil Jabatan Kebajikan Masyarakat dan wakil Lembaga Penduduk dan Pembangunan Keluarga Negara (LPPKN). Kajian mendapati badan-badan NGO memainkan peranan yang sangat penting membantu kerajaan dan golongan OKU pendengaran sendiri dalam usaha meningkatkan kualiti insititusi kekeluargaan Islam golongan tersebut melalui program-program yang sesuai.
The participation of hearing impaired people in any program related to Islamic family development is very limited and limited, including their participation in pre- and post-marriage courses due to the lack of facilities to participate in related programs. The commitment and participation of the hearing impaired in the programs depends a lot on the initiative and cooperation of non-governmental organizations (NGOs) whether NGOs are involved with the hearing impaired directly or indirectly. Therefore, this study aims to identify the role of NGOs as a support system for the disabled in the development of Muslim families among them. This study is a qualitative field study involving the method of data collection through a round table discussion (Round Table Discussion/RTD) involving informants consisting of representatives of NGOs with disabilities, academics, representatives of the State Religious Affairs Department, representatives of the Islamic Development Department of Malaysia as drafters of MBKPPI, representatives of the Social Welfare Department and representatives of the National Population and Family Development Board (LPPKN). The study found that NGOs play a very important role in helping the government and the hearing impaired themselves in an effort to improve the quality of Islamic family institutions for the group through appropriate programs.
Benefits of a dual focus methodology utilising IPA and FDA in understanding meaning-making around the experience of psychosis
Authors: Baboulene Katy , Willig Carla
Published: July 2023

A dual focus methodology combining Interpretative Phenomenological Analysis (IPA) and Foucauldian Discourse Analysis (FDA) was utilised to explore both language and the subjective embodied experience of psychosis. Despite arguments that combining IPA and FDA creates epistemological/ontological conflicts due to the dissonant theoretical underpinnings, adoption of a critical realist position permitted an integration of these approaches. A combined methodological approach enabled a more comprehensive understanding of the experience of psychosis, from both a discursive and subjective embodied perspective. Adoption of this binocular approach resulted in recommendations for research methodology and clinical/counselling psychology practice.
Ethical Leadership in the Digital Age: Assessing the Role of Leaders in Nurturing Ethical Behavior in Technology-Driven Organizations
Authors: Vaja Jignesh R
Published: July 2023

This research paper investigates the role that leaders play in the development of ethical behaviour within technology-driven organisations in the modern day via the lens of a research question. Because of the fast advances in technology, organisations are now faced with one-of-a-kind ethical dilemmas that can only be navigated successfully with strong leadership. The purpose of this research is to evaluate the significance of ethical leadership in establishing an ethical culture and encouraging the responsible use of technology. This paper investigates the role that leaders play in establishing ethical norms, serving as an example of ethical behaviour, and fostering an atmosphere that encourages ethical decision-making. In addition to this, the article underlines the ethical implications of new technology and analyses several techniques for establishing ethical leadership in today's digital age. This study intends to give insights into the relevance of ethical leadership in technology-driven organisations and to advise future leadership practises in the digital age by evaluating the effect that ethical leadership has on the results of organisational activities.
CEZAYA DEĞER HAKSIZLIĞIN FORMEL TESPİTİNDE PARÇA HAREKET TEORİSİ (TEIL-/ZWISCHENAKTSTHEORIE) VE HUKUKUMUZ BAKIMINDAN UYGULANABİLİRLİĞİ
Authors: ÇATAKLI Hasan
Published: July 2023

Ceza hukukunun suça yönelmiş bir insan davranışını hangi andan itibaren cezaya değer bir haksızlık olarak kategorize edebileceği sorusu, suça teşebbüste icra başlangıcının tespiti ile doğrudan doğruya bir ilişki içerisindedir. Bu bakımdan icra başlangıcının tespitine yönelmiş teorilerin cezaya değer haksızlığın yapısı ve norm teorisi bakımından da ele alınması gerekliliği söz konusudur. Çalışma icra başlangıcı kavramının öncelikli olarak cezaya değer haksızlığın yapısı bakımından oturduğu düzlemi formel ve maddi açıdan ele almakta ve hareketin haksızlığında bulunması gereken objektif unsuru tanımlamaktadır. Söz konusu değerlendirmeler bağlamında Alman Ceza Hukuku literatüründe icra başlangıcı bakımından hâkim görüş olan Parça/Ara Hareket Teorisini cezaya değer haksızlığın formel tespitinde değerlendirmekte ve teorinin uygulanışını çalışmanın boyutlarının elverdiği ölçüde, Türk Ceza Hukuku açısından teorinin uygulanabilirliğini de sorgulayarak, ayrıntılı olarak incelemektedir.
İNGİLTERE, ABD, ALMANYA VE FRANSA’DA VERGİ SUÇLARI VE YARGILAMA SÜRECİNİN DEĞERLENDİRİLMESİ
Authors: ÖZ Ersan , SEVİNÇ CEYHAN Cansu
Published: July 2023

Vergi kanunlarında mükelleflere yüklenen ödevlerin mükellefler tarafından ihlal edilmesi halinde mükellefler çeşitli yaptırımlara tabi tutulmaktadır. Vergi kanunlarının ihlaline neden olan davranışlar, ihlalin derecesine göre vergi kabahatleri ve vergi suçları olarak adlandırılmaktadır. Hemen her ülkede, hafif olarak kabul edilen vergi ihlâlleri para cezasına tabi tutulmakta iken ağır ihlâller suç kabul edilerek hürriyeti bağlayıcı cezaya tabi tutulmuştur. Çalışmamızın amacı, vergi suç ve ceza sisteminin ve yürütülen yargılama sürecinin aydınlatılarak evrensel yargılama ilkeleri bağlamında değerlendirilmesidir. Farklı yargılama sistemine sahip ülkeler arasından İngiltere, Amerika Birleşik Devletleri, Almanya ve Fransa seçilmiştir. Seçilen ülkelerde vergi suçları ve cezaları, sistematik yeri saptanarak incelenmiş; ardından vergi suçlarının yargılama süreci, soruşturma ve kovuşturma evrelerine ayrılarak değerlendirilmiştir. Çalışmamızın sonucunda farklı hukuk sistemlerindeki ülke örnekleri incelenerek vergi suçlarının yargılama sürecinin bir bütün olarak değerlendirilmiş, bu bağlamda sorunlar saptanarak çözüm önerileri sunulmuştur.
TEHDİT VE ŞARTLI TEHDİT KAVRAMLARI BAĞLAMINDA TEHDİT SUÇUNUN BİR ŞARTA BAĞLI OLARAK İŞLENMESİ
Authors: TURİNAY Faruk Yasin
Published: July 2023

Tehdit fiilleri kanun koyucunun tercihine göre tek bir suç olarak düzenlenebileceği gibi basit tehdit ve şartlı tehdit şeklinde iki ayrı suç halinde de düzenlenebilir. Tehdit fiillerinin birden fazla bağımsız suç tipi olarak düzenlenmesi halinde “tehdit suçları” adı altında bir suç kategorisinin varlığından söz etmek mümkündür. Yürürlükteki Türk ceza hukukunda şartlı tehdit adı altında bir suç tipi bulunmamaktadır. Buna karşılık mülga 765 sayılı Türk Ceza Kanunu dönemindeki Türk ceza hukukunda şartlı tehdit suçu mevcuttu. Ancak şartlı tehdit sadece ceza hukuku tarihine ilişkin, arkaik, geçerliliğini yitirmiş bir kavram değildir. Gerçekten, şartlı tehdit karşılaştırmalı hukuk açısından halen geçerli bir kavram ve suç tipi olma özelliğini sürdürmektedir. Örneğin yürürlükteki İtalyan Ceza Kanunu’nun yanı sıra 1992’de kabul edilen ve 1994’te yürürlüğe giren Fransız Ceza Kanunu’nda da şartlı tehdit, basit tehdit suçunun yanı sıra bağımsız bir suç tipi olarak düzenlenmiştir. Şartlı tehdit, hem tehdit fiillerinin yaygın görülen bir hali, hem kendine özgü morfolojik özellikleri olan bir hürriyete karşı suç, hem de basit tehdide kıyasla irade hürriyetini daha ağır surette tehlikeye sokan bir fiil mahiyetindedir. Bu nedenle, 5237 sayılı Türk Ceza Kanunu’nda bu doğrultuda değişiklik yapılarak şartlı tehdit fiilinin Kanun’un 106. maddesindeki suçtan daha ağır cezalandırılan, bağımsız bir suç tipi olarak düzenlenmesini öneriyoruz.
Research on Big Data-driven Business Management Effectiveness Enhancement Methodology
Authors: Wang Jiawen
Published: July 2023

In the digital era, business management effectiveness enhancement is an important way to promote enterprises to gain competitive advantage, and enterprises use big data to drive business model innovation and business risk warning. Based on the progress of existing data-driven business model research, the intrinsic mechanism and methods of big data-driven business model innovation are analysed based on the perspective of business model element restructuring. Meanwhile, in business risk management, especially in the financial banking sector, where risk management is the core of its business management, big data plays a crucial role.
Do Selective Industrial Policies Reduce the Tendency of Enterprises to Economic “Off real to virtual”--Evidence based on the qualification of high-tech enterprises
Authors: Yang Shikun , Yang Tianqi , Yin Mingjun
Published: July 2023

The accreditation of high-tech enterprises is an important policy which is put forward by the state to support and encourage the development of high-tech enterprises. This paper takes the policy of high-tech enterprises accreditation as the research object, adopts the staggered difference in differences (DID) research method, and based on the relevant data of A-share listed companies from 2007 to 2021 to explores the relationship between the selective industrial policies and the tendency of enterprises to economic “off real to virtual”. The economic “off real to virtual” of enterprises is manifested in the rise of the financial level of enterprises. When an enterprise holds too much financial assets, it has a crowding out effect on its main business and brings certain negative impacts on the enterprise and the economy, which is not conducive to the development and smooth operation of the industry and the national real economy. The results show that the policy of high enterprise accreditation significantly inhibits the level of financialization of enterprises, and the degree of influence on the level of enterprise financialization is related to the property nature of enterprises, the size of enterprises and other characteristics. On this basis, the degree of influence is discussed in groups according to the liquidity difference of financial assets. From the perspective of influence mechanism, the policy of high-tech enterprise accreditation mainly reduces the degree of enterprise financialization from the aspect of tax relief.
A Review of Text Sentiment Analysis Methods and Applications
Authors: Jin Yuxin , Cheng Kui , Wang Xinjie , Cai Lecai
Published: July 2023

This paper reviews the application of natural language processing in sentiment analysis. Sentiment analysis is an important task aimed at automatically identifying and inferring sentiment tendencies and sentiment intensity in texts. This paper first introduces the application areas of sentiment analysis, including practical applications of text sentiment analysis. Then, text pre-processing techniques such as word separation, deactivation removal and punctuation processing are discussed. Then, feature extraction and representation methods are explored, including bag-of-words model, TF-IDF, word embedding and Word2Vec, attention mechanism and Transformer. In addition, methods for sentiment analysis, such as sentiment dictionaries and rule-based methods, traditional machine learning methods, and deep learning-based methods, are presented. Finally, the application areas of sentiment analysis are discussed and conclusions are given. The review in this paper will help readers understand the current status and development trend of natural language processing applications in sentiment analysis, as well as the advantages and disadvantages of different methods in sentiment analysis.
Coopetition Strategy Choice of Duopoly Manufacturers with Key Component Technology Transfer
Authors: Ma Shixin
Published: July 2023

This paper investigates the strategic choice of key component technology transfer between two rival manufacturers. A benchmark competition model and two coopetition models (including fixed-fee licensing coopetition and two-part tariff licensing coopetition) where the manufacturers compete for end-customer demand while simultaneously collaborating on key component technology transfer through licensing. By comparing the outcomes of the competition model and coopetition models, it is shown that: (1) The optimal strategy choice for manufacturers depends on the degree of product substitution, the interfirm power relationship as well as the production cost difference of key components. Among them, the interfirm power relationship has the most significant impact on the optimal strategy choice. (2) Under certain conditions, fixed fees and two-part tariff patent licensing coopetition can achieve Pareto improvement and reduce the retail price of products, which is beneficial to both manufacturers and consumers. (3) The production cost difference of key components significantly affects whether manufacturers can achieve Pareto improvement under two coopetition models.
Analysis of the Formation and Revelation of International Financial Crisis Based on the Theory of Economic Crisis
Authors: Xian Ziyao
Published: July 2023

At present, China is in a new period of rapid development, and a sound financial market and regulatory system is necessary to meet the needs of the market economy, achieve rational allocation of resources, and serve the real economy with financial precision. On this basis, this topic intends to explain the causes and essence of the occurrence of the current international financial crisis within the perspective of economic crisis theory, and on this basis, to discuss how to use economic crisis theory to control and contain the occurrence of the international financial crisis from the new development stage, so as to provide reference for our country to prevent and cope with financial risks in the new development stage.
The Current Situation and Optimization Strategies of School Soccer Development in China
Authors: Zhang Yongpeng , Ch.Zegiimaa
Published: July 2023

In this paper, through an in-depth study on the development of campus soccer, the development of schools with campus soccer characteristics and the influencing factors are studied, the current situation of development, teachers, field equipment and financial investment are analyzed, problems in the process of development are sought, optimization strategies are explored, and successful experiences are summarized to provide reference for the development and implementation of campus soccer.
Exploring the Path of Transformation and Upgradation of Guangdong's Processing Trade
Authors: Lyu Yuyan
Published: July 2023

Processing trade has developed rapidly in Guangdong since the reform and opening up, making a huge contribution to the economic development of Guangdong. However, there are also many problems in the development of processing trade, such as weak independent innovation ability of processing trade enterprises, lack of brand awareness, and low technological content of processing trade products. Therefore, studying Guangdong's processing trade and pointing out the direction and countermeasures for the transformation and upgrading of Guangdong's processing trade have important practical significance.
On the Importance of Pricing Strategy in Marketing Strategy
Authors: Gao Runting
Published: July 2023

This paper investigates the significance of pricing strategies within the scope of marketing strategies. Emphasizing its central role, the research delineates various types of pricing strategies, exploring how they can differ based on industry applications. By employing a literature review and case study methodology, we analyze the challenges faced by businesses when implementing pricing strategies, along with the potential future trends in this domain. The conclusion accentuates that, in an increasingly competitive market, businesses need to effectively craft and constantly optimize their pricing strategies in alignment with consumer behaviors, regulatory constraints, data-driven challenges, and considerations for sustainability and social responsibility. As personalization, dynamic pricing, transparency, and fairness become prevalent, businesses are offered opportunities and challenges that necessitate strategic evolution for sustained competitiveness.
Research on the Impact of E-commerce on Offline Retail Industry
Authors: Wang Tianyu
Published: July 2023

This research paper investigates the impact of e-commerce on the offline retail industry, examining both the challenges and opportunities it presents. The research draws on various sources, including industry reports, academic literature, and a case study of Costco, to provide an in-depth analysis of the topic. The paper begins by exploring the evolution of e-commerce and its effects on offline retailers, followed by a discussion of strategies offline retailers can employ to adapt to the changing retail landscape. These strategies include adopting an omnichannel approach, enhancing in-store experiences, utilizing data analytics and AI, and fostering strategic partnerships. The paper concludes with an outlook on the future of the offline retail industry, suggesting that continual innovation and customer-centric approaches are key for success. The findings of this research can provide valuable insights for offline retailers seeking to navigate the rapidly evolving retail environment in the age of e-commerce.
Will the Regulation of Exchange Inquiry Letters Affect the Investment Efficiency of Enterprises?
Authors: Lu Sen , Qian Hanyu
Published: July 2023

Exchange inquiry letter is an important and innovative regulatory method, and the efficiency of corporate investment decision-making and theft has not been studied. Theoretically, inquiry letter regulation may have a positive and negative opposite effect on the efficiency of a company's investment. Based on this, this paper adopts the multi-period double difference model used by A-share non-financial listed companies in Shanghai and Shenzhen from 2014 to 2021, and empirical research finds that the inefficient investment of companies receiving inquiry letters from exchanges has significantly improved, and the inquiry letter system of exchanges has reduced the investment efficiency of companies.