bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor – Faktor yang Memengaruhi Minat Nasabah Bank dalam Pemanfaatan Layanan Mobile Banking di PT Bank Syariah Indonesia KCP Medan Pulo Brayan
Authors: Hidayah Nurul , Hamdani Muhammad Faisal
Published: December 2024

This research aims to analyze and test the influence of information technology, usefulness and trust on customer interest in using mobile banking services at Bank Syariah Indonesia KCP Medan Pulo Brayan. The methodology used is a quantitative approach. The research subjects were 100 mobile banking users of Bank Syariah Indonesia KCP Medan Pulo Brayan. This research uses primary data collected through surveys. Data analysis in this research uses the SPSS software program to calculate validity, reliability, multiple regression, classical theory, f-test, t-test, and coefficient of determination. This research found that information technology, usability, and trust all have partial and simultaneous effects on customer interest in using mobile banking services at Bank Syariah Indonesia KCP Medan Pulo Brayan.
Praktik Perjokian Tugas: Dimensi Nilai Kejujuran dan Integritas Perspektif Hukum Islam dan Hukum Positif
Authors: Rahman Azis , Hidayat Muhammad Nur , Kurniati Kurniati
Published: December 2024

The phenomenon of assignment jockeying is a reality of cheating and a bad habit for a student. The practice means paying someone else to complete the assignment of the user. This arises because of the various motives and reasons behind this assignment jockeying action, namely high academic pressure, not understanding or understanding the learning process and the material presented, lack of time, and so on. This research applies the normative theological and juridical approach in answering the issue of the practice of assignment jockeying. Based on this study, it is concluded that the practice of task cheating is contrary to the value of honesty (al-sidq) and integrity. Honesty is the main foundation in studying and interacting in society. Using jockey services means betraying trust, avoiding responsibility, and creating injustice for oneself and others. In addition, this practice also contradicts hifz al-aql (preserving reason) and hifz al-mal (preserving wealth). The education regulatory system in Indonesia is considered contradictory because it ignores the values of honesty, integrity and independence that are the cornerstones of education. The issue is also still being debated due to the weak existing regulations. However, it should be noted that the consequences of the practice will create graduates who are incompetent and unprepared to face challenges in society.
AKAR PEMIKIRAN MOHAMMED ARKOUN
Authors: Nasrullah Nasrullah
Published: December 2024

Satu diantara indikasi kemunduran dan kemandegan ilmu pengetahuan umat Islam periode pertengahan adalah corak pemikiran bersifat teologi Islam klasik. Suatu keyakinan yang corak pemikirannya masih bersifat transendental-spekulatif bahkan kurang peduli terhadap persoalan realitas empiris kehidupan masyarakat. Padahal kehidupan manusia terus berkembang dan berubah seiring perkembangan ilmu dan peradaban manusia. Teologi ini terus mendapat dukungan dari pemilik otoritas kekuasaan dan para ulama, sehingga membentuk format ortodoksi, yang berimplikasi pada pola berpikir dalam bidang pendidikan, hukum, etika, sosial budaya, filsafat dan sebagainya. Model-model pemikiran di atas merangsang Mohammed Arkoun untuk berpikir keras agar umat Islam terhindar dari kondisi tersebut, paling tidak membawa umat Islam keluar dari kungkungan kejumudan pemikiran, melihat dunia luar yang lebih realistis-objektif dan mencitrakan kembali Islam sebagai agama yang rahmatan lilʻālamīn.
MANAJEMEN PEMBELAJARAN PENDIDIKAN AGAMA ISLAM BERBASIS ACCELERATED LEARNING
Authors: Susilawati Susilawati
Published: December 2024

Manajemen diartikan sebagai keterampilan untuk memperoleh suatu hasil dalam rangka pencapaian tujuan melalui kegiatan-kegiatan orang lain. Konsep manajemen diartikan serangkaian kegiatan merencanakan, mengorganisasikan, mengendalikan dan mengembangkanterhadap segala upaya dalam mengatur dan mendayagunakan sumber daya manusia, sarana dan prasarana secara efisien dan efektif untuk mencapai tujuan organisasi yang telah ditetapkan. Pembelajaran PAI berbasis Accelerated Learning meliputi : Persiapan, Presentasi, Latihan dan penampilan. secara terminologi model pembelajaran Accelerated Learning (pembelajaran yang dipercepat) adalah suatu pola yang digunakan dalam pembelajaran yang didesain sedemikian rupa sehingga dapat menggugah kemampuan belajar peserta didik, membuat belajar lebih menyenangkan dan lebih cepat. Cepat, disini diartikan dapat mempercepat penguasaan dan pemahaman materi pelajaran yang dipelajari, sehingga waktu yang dibutuhkan untuk belajar lebih cepat.
Extended Technology Acceptance Model (TAM) for Evaluating Digital Banking Adoption in Saudi Arabia
Authors: Alamir Ibrahim
Published: December 2024

This study investigates the factors influencing the acceptance and use of digital banking services in Saudi Arabia, applying the technology acceptance model. Data were collected from 406 respondents using a structured survey to measure perceived usefulness (PU), perceived ease of use (PEOU), Trust, social influence (SI), perceived risk (PR), behavioral intention (BI), and actual usage. The results showed that PU, PEOU, Trust, SI, and BI significantly positively affected digital banking usage, while PR had a significant negative impact. The findings align with existing literature, reinforcing the importance of user-friendly interfaces, robust security measures, and SI in driving digital banking adoption. Practical implications include enhancing digital banking platforms' usability and trustworthiness to boost user engagement. Future research should consider longitudinal studies and explore the impact of emerging technologies on digital banking adoption.
KEYWORDS
digital transformation, adoption behavior, perceived usefulness (PU), perceived ease of use (PEOU)
Examining the Synergism of Cerium Oxide Nanoparticle – Andrographolide Conjugate and Studying its Potential Role Towards Antioxidative Therapeutics
Authors: Kumari Sneha , Pandey Shivam , Manohar Aeshala Leela , Kumar Anuj , Singh Sushant
Published: December 2024

Increased oxidative stress in metabolic disorders has revealed promising alternatives for antioxidative therapeutics. Herein, we present synthesis and evaluations of Cerium oxide nanoparticles (CNPs) conjugated with Andrographolide (Ad-CNP). Characterization revealed a uniform particle size of 106 nm for bare CNP and 120 nm for Ad-CNP conjugates. UV-visible spectroscopy showed an absorbance peak at 230nm, indicating a high Ce³⁺/Ce⁴⁺ oxidation state. X-ray diffraction confirmed a pure cubic fluorite structure with a polycrystalline nature with peaks at 111, 200, 220, and 311. In terms of reactive oxygen species scavenging, bare CNPs demonstrated Catalase mimetic activity of 41.5%, whereas the Ad-CNP conjugates showed 47% scavenging activity. The Superoxide Dismutase mimetic activity was significantly increased due to synergy up to 77% of Ad-CNP whereas bare CNPs showed 57% activity.  The CNPs exhibited notable antibacterial efficacy, diminishing microbial proliferation by 69% for bare CNPs and 82% for Ad-CNP. Biocompatibility testing with human skin keratinocytes validated the safety of the nanoparticles, and anti-inflammatory assays indicated decreased expression of pro-inflammatory cytokines IL-6 and TNF-α. The synergistic combination of CNPs with Andrographolide demonstrated significant potential as a potent antioxidant, antibacterial, and anti-inflammatory agent, making it a prospective candidate for antioxidative therapeutic research aimed at diminishing oxidative stress.
Simulasi Pemodelan Arus Pasang Surut di Perairan Teluk Jakarta
Authors: Bakri Muhammad , Santosa Yoyok Nurkaya , Awaluddin Awaluddin , Hawati Hawati , Malik Kurnia , Pranowo Widodo Setiyo
Published: December 2024

Teluk Jakarta merupakan salah satu perairan penting di Indonesia yang berperan besar dalam aktivitas ekonomi, pelayaran, pertahanan dan wisata pantai. Aktivitas tersebut tentu tidak lepas dari pengaruh oseanografi fisik salah satunya yaitu pola pasang surut dan arus laut. Penelitian ini bertujuan untuk melakukan simulasi pemodelan arus pasang surut di perairan teluk Jakarta menggunakan perangkat lunak mike 21. Pemodelan ini diperlukan untuk memahami dinamika arus pasang surut yang berpengaruh terhadap aktivitas pesisir dan infrastruktur di teluk Jakarta. Data yang digunakan dalam penelitian ini yaitu data batimetri, data angin, dan data pasang surut. Hasil simulasi pemodelan mike 21 selama 1 bulan di area teluk Jakarta didapatkan bahwa kecepatan arus pasut maksimum 0.15 m/s dengan tipe pasang surut harian tunggal (diurnal). Data pengamatan digunakan untuk memvalidasi data hasil model mike 21, validasi dilakukan untuk mengetahui keakuratan data hasil pemodelan yang telah dilakukan. Hasil validasi pasut mendapatkan nilai RMSE 0.13 dan validasi arus mendapat nilai RMSE 0.05. dari hasil validasi yang telah dilakukan bisa di simpulkan bahwa pemodelan yang telah dilakukan sudah cukup bagus karena mendekati nilai tinggi air yang sebenarnya.
Massa Air di Laut Maluku Berdasarkan Data Observasi Opssurta ALKI III “Laut Maluku” dan Data Model Global
Authors: Heriyanto Dwi , Pranowo Widodo Setiyo , Khair Deirus Rizki , Yulianto Yulianto
Published: December 2024

Laut Maluku merupakan salah satu perairan yang ada di Indonesia dengan kondisi topografi dasar laut yang beraneka ragam, memiliki kedalaman laut hingga 4000 meter dan berbatasan dengan Samudera Pasifik sehingga memiliki karakteristik massa air laut yang unik. Penelitian ini bertujuan untuk mempelajari sifat distribusi massa air, dan untuk mengevaluasi distribusi suhu, salinitas serta densitas yang mencirikan massa air di Laut Maluku dari hasil penelitian dengan data model global CMEMS (Copernicus Marine Environment Monitoring Service). Penggambaran variabel massa air dari data model global dan observasi Opssurta ALKI III Laut Maluku tersebut dilakukan dengan perangkat lunak ODV V.5.7.1 untuk mengklasifikasikan jenis massa air berdasarkan daerah asalnya. Hasil penelitian menunjukan jenis massa air yang didapat antara kedua data yang didominasi oleh 3 jenis massa air yaitu massa air yang berasal dari Samudera Pasifik Utara berupa Western South Pacific Central Water dengan karakteristik suhu 6°-22°C dan salinitas 34,5-35,8 psu, massa air yang berasal dari Samudera Pasifik Selatan berupa Eastern South Pacific Central Water dengan karakteristik suhu 8°-24°C dan salinitas 34,4-36,4 psu, North Pacific Equatorial Water dengan karakteristik suhu 6°-16°C dan salinitas 34,5-35,2 psu.
A case of Fahr’s disease in a patient treated for Parkinson’s
Authors:   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Mihalcea Maria
Published: December 2024

Fahr’s disease (FD), also referred as familial idiopathic basal ganglia calcification (FBGC) or bilateral striopallidodentate calcinosis (BSPDC), is a rare neurodegenerative disorder characterized by bilateral calcification of the basal ganglia and other brain regions. FD typically presents with a diverse range of clinical symptoms, including neuropsychiatric manifestations, movement disorders, and various neurological features. This article presents a case of a 71-year-old woman with a complex clinical history. She initially presented with symptoms of an anxious depressive disorder, which were followed by the development of gait disturbances, tremor, and sudden blindness in her right eye. Over time, these symptoms become associated with cognitive disturbances. Initially misdiagnosed as Parkinson’s disease, the patient was treated with levodopa-carbidopa, which led to medication induced psychosis. Subsequent evaluation revealed brain calcification consistent with FD. The case illustrates the diagnostic challenges associated with FD, as it can mimic other neurodegenerative condition, and emphasizes the importance of a comprehensive diagnostic approach. Additionally, it highlights the importance of recognizing and managing medication-induced side effects, particularly in elderly patients with multiple comorbidities.
Interplay of neuroendocrine tumor progression, chronic alcohol use, and depression: A complex case analysis and multidisciplinary approach
Authors:   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Horosan Lavinia , Saftencu Mihai ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Nistor Diana-Elena ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Ion Adriana ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Giurgiuca Ana ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: December 2024

Neuroendocrine neoplasms are a diverse group of tumors with hormone-secreting potential, affecting patient quality of life and prognosis. This report discusses a 56-year-old male with a likely intestinal-origin neuroendocrine tumor and a 20-year history of heavy alcohol use, who developed a major depressive episode, following his cancer diagnosis. Diagnostic imaging and histology confirmed a well-differentiated neuroendocrine tumor (NET G1), and treatment with Octreotide and Everolimus was initiated due to disease progression. Despite treatment, he developed gastrointestinal complications and persistent endocrine disturbances, requiring recurrent ascitic drainage. This patient’s depressive episode appears multifactorial, with contributions from neuroendocrine and alcohol-related neurotoxic effects, compounded by psychological distress over his cancer prognosis. A multidisciplinary approach is crucial for managing both his oncologic and psychiatric symptoms. This case highlights the need for further research into the complex interaction between neuroendocrine neoplasms, mood disorders, and substance use, aiming to improve management and quality of life for similar patients.
Training programs in old age psychiatry throughout Europe
Authors:   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Corban Mihai , Nistor Diana-Elena ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Horosan Lavinia ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Ion Adriana ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Saftencu Mihai ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Giurgiuca Ana ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: December 2024

The European population is ageing, with a projected increase in the number of elderly individuals, leading to a higher prevalence of psychiatric disorders among this demographic. To address this issue, the European Union of Medical Specialists (UEMS) established a working group focused on postgraduate training in Psychiatry. Old Age Psychiatry (OAP), a subspecialty dealing with psychiatric disorders in individuals over 65 years old, requires a multidisciplinary approach due to the complex nature of these cases. This paper reviews the training curricula for psychiatric residents in OAP across Europe, highlighting the need for harmonization to ensure consistent standards of care. PubMed and Google Scholar databases were systematically reviewed, yielding five relevant articles focusing on OAP training in Europe. The review revealed variations in the recognition and duration of OAP training across European countries. While some countries officially recognize OAP as a subspecialty or special competence, others offer additional training within general psychiatry residencies. Romania, among Eastern European countries, has shown increasing interest in psychogeriatrics, with notable achievements in this field. However, challenges exist in accessing comprehensive information on training curricula, particularly in Eastern Europe. The paper underscores the importance of adequate training in OAP to meet the growing demands of an ageing population and advocates for standardized training programs across Europe to ensure consistent quality of care. This approach would enable psychiatrists to practice across European countries seamlessly and contribute to addressing the mental health needs of elderly individuals effectively.
From madness to modernity: The enlightenment and the evolution of psychiatry
Authors:   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Horosan Lavinia , Nistor Diana-Elena ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Ion Adriana ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania, Giurgiuca Ana ,   “Prof. Dr. Alexandru Obregia” Clinical Psychiatry Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: December 2024

Psychiatry’s development as a discipline reflects its deep historical and cultural roots, interwoven with humanity’s evolving understanding of the mind. While the 19th-century establishment of psychiatry in Germany formalized its medical identity, its intellectual and cultural origins trace back to antiquity, where disturbances in cognition and emotion were perceived through artistic, religious, and philosophical lenses. These early interpretations often stigmatized mental illness, a pattern perpetuated by Enlightenment ideals that equated rationality with humanity, marginalizing those who deviated from societal norms. The Enlightenment catalyzed a pivotal transformation in psychiatry, ushering in rational, evidence-based approaches. The period emphasized the therapeutic potential of institutions, humanized treatment, and the curability of mental disorders. Pioneers like William Battie, Philippe Pinel, and Vincenzio Chiarugi laid the groundwork for compassionate care, while Johann Christian Reil coined “psychiatry,” advocating specialized care frameworks. Contributions from Jean Etienne Esquirol, Benjamin Rush, and others expanded the field’s scope, emphasizing moral treatment, psychological interventions, and diagnostic rigor. Psychiatry’s evolution underscores shifting paradigms between naturalistic and moralistic models of mental illness, reflecting broader societal, intellectual, and cultural trends. By integrating biological and psychosocial insights, the field has balanced scientific rigor with humanitarian care, contributing to humanity’s ongoing quest to understand and heal the mind.
Analysis Of XXX Service Quality Using The E-Service Quality And Importance Performance Analysis
Authors: Aswarasy Kardinna , Bernik Merita
Published: December 2024

The trend of digital banking is growing with easy access through mobile banking such as XXX marked by performance that increases every year and is included in the most frequently used mobile banking. However, some users complain about XXX application problems related to the services provided, namely not being able to log in easily, requests cannot be processed, the application is very slow, and other problems. To solve this problem, XXX needs to improve the performance of the services provided. This study aims to determine the current service quality of XXX as well as the gap between customer perceptions and expectations and find out the attributes that are prioritized to improve service quality. The research method used is E-Service Quality with 6 variables, namely site organization, reliability, responsiveness, user friendliness, personal needs, and efficiency followed by the Importance Performance Analysis method through a quantitative approach. From the research results, it is found that the quality of XXX service provided is not yet qualified based on the level of conformity with an average value of 98% and the level of gap with an average value of -0.08 which explains that the current service quality is not in accordance with the quality expected by users. Then, the factors that need to be prioritized are statement items in quadrant concentrate here, namely Pages in the XXX app do not stop working suddenly, XXX app can be used immediately and runs smoothly, I can complete transactions quickly in the XXX app, XXX app provides services exactly at the time specified, and XXX app is easy to use.
The predictive role of inflammatory biomarkers based on first trimester complete blood count parameters for the risk of HELLP syndrome : A case-control study
Authors: Özkan Sadullah , Fıratlıgil Fahri Burçin , Kurt Dilara Sarıkaya , Kurt Ahmet , Topkara Sucu Serap , Sucu Sadun , Dereli Murat Levent , Çelen Şevki
Published: December 2024

Aim; To conclude the predictive role of inflammatory biomarkers based on first trimester complete blood count parameters for the risk of HELLP syndrome.
Materials and methods; This case-control study was included 45 of 73 pregnant women with HELLP syndrome. Clinical data and laboratory results were retrieved by medical and hospital records. We compared the inflammatory biomarkers based on first trimester complete blood count parameters for the risk of HELLP syndrome.
Results; We recruited 45 cases (pregnant women with HELLP syndrome) and 45 controls (healthy pregnant women), matched for body mass index, gravidity, parity and gestational week. The lymphocyte, platelets - lymphocyte ratio, neutrophil - lymphocyte ratio and systemic inflammation index values were statistically significant (p
Evaluation of Prenatal Invasive Testing Complications in a Tertiary Care Centre
Authors: Bütün Zafer , Kayapınar Masum , Akça Salık Ece , Şenol Gökalp , Suman Kamuran
Published: December 2024

Aim:
Invasive tests such as amniocentesis or chorionic villus sampling (CVS) are associated with an increased risk of miscarriage, testing should be done with caution in pregnancies considered to be at high risk for aneuploidies and other genetic disorders.
The aim of our study is to present the complications that develop after invasive prenatal tests such as amniocentesis, cordocentesis and chorionic villus sampling.
Methods:
A retrospective observational study was conducted covering a period of 3 years and 1 month, involving 282 pregnant women at high risk of genetic disorders who underwent invasive prenatal testing such as chorionic villus sampling, amniocentesis, or cordocentesis.
Results:
A statistically significant difference was found in at least one group in terms of gestational age at delivery, birth weight, current week and pregnancy risk among amniocentesis, cvs and cordocentesis groups (p
Clinical use of PGE2 (dinoprostone) and cervical ripening balloon catheter during delivery induction in patients with a Bishop score of ≤4 with vertex presentation
Authors: Şerbetçi Hakkı , Velipaşaoğlu Melih , Tanır Mete
Published: December 2024

Purpose: We aimed to compare the clinical use of PGE2 (dinoprostone) and cervical ripening balloon catheter for delivery induction in patients with a Bishop score of ≤4 with vertex presentation.
Material and Methods: This study was retrospectively conducted and included the induction of labor between January 2014 and January 2017 at Eskisehir Osmangazi University, Department of Obstetrics and Gynecology. There was a total of 60 patients in the study and 30 patients were given dinoprostone and 30 patients were given birth by double balloon catheter. We compared the clinical results of the patients. Multivariable regressions were used to identify odds of induction success.
Results: There was no significant difference between the demographic characteristics of the patients. When the clinical results of the patients were compared, there was no difference between the vaginal delivery rate and the delivery time between the two groups. The duration of active labor in the balloon catheter group was statistically significantly longer (p = 0.036). The amount of postpartum hemorrhage in the balloon catheter group was also significantly higher (p = 0.008).
Conclusion: The ideal agent to be used in cervical pregnancy is still a controversial issue. In this regard, more work needs to be done with the patient.
Is the use of first-trimester systemic inflammation markers predictive in fetal growth restriction?
Authors: Ağaoğlu Zahid , Tanacan Atakan , Denizli Ramazan , Sakcak Bedri , Farisoğulları Nihat , Haksever Murat , Kara Özgür , Sahin Dilek
Published: December 2024

Aim: To predict fetal growth restriction (FGR) and its effect on prognosis according to changes in systemic inflammation indexes, such as the neutrophil-to-lymphocyte ratio (NLR), the systemic immune-inflammation index (SII), and the systemic inflammation response index (SIRI).
Materials and Methods: The study group consisted of 200 women with singleton pregnancies diagnosed with FGR, and the control group comprised 280 obstetrically and demographically matched healthy pregnant women. The NLR, SII, and SIRI were compared between the groups according to the first-trimester complete blood count results.
Results: When the groups were compared in terms of systemic inflammation indexes, the NLR, SII, and SIRI were found to be statistically lower in the FGR group (p
The Utility of the Systemic Immune-Inflammation Index (SII) and the Systemic Immune-Response Index (SIRI) in predicting pregnancy-related cerebral venous sinus thrombosis: An experience from a tertiary center
Authors: Başaran Ezgi , Tanacan Atakan , Farisoğulları Nihat , Ağaoğlu Zahid , Şerbetçi Hakkı , Kara Özgür , Özcan Namık , Sahin Dilek
Published: December 2024

Aims: Our aim in this study was to investigate the difference of systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) indices between pregnancy-related cerebral venous sinus thrombosis (CVST) patients and healthy pregnant and postpartum women and to evaluate the association between these indices and disease severity and prognosis in the CVST group.
Materials and Methods: This retrospective study included 21 patients with CVST and 80 healthy pregnant and postpartum patients as the control group. We looked at whether there was a statistical difference in demographic and clinical characteristics and laboratory results between the groups. Then we compared the SII and SIRI values, whose prognostic value has been studied as new inflammatory indices in many subjects.
Results: Neutrophil, monocyte, lymphocyte and platelet counts were similar between the groups. SII and SIRI were significantly higher in the CVST group (p:0.006, p:0.043; respectively). It was found that the SII and SIRI indices were higher in the group with severe disease and the poor prognosis, but the results were not statistically significant.
Conclusion: These results showed us that the SII and SIRI indices can be used as a supporting factor for the diagnosis in patients with suspected CVST. Studies with more patients may help to demonstrate the impact of SII and SIRI indices on disease severity and prognosis.
Deux visions du noir : le roman Jack’s Return Home de Ted Lewis et le film Get Carter de Mike Hodges
Authors: BROCHIER Christophe
Published: December 2024

Cet article propose une étude du roman de Ted Lewis, Jack’s Return Home (1970) et de son adaptation cinématographique, Get Carter (1971) par le réalisateur et scénariste Mike Hodges. En étudiant le contexte de l’élaboration des deux œuvres ainsi que le détail de leur contenu, je cherche à montrer que Lewis et Hodges proposent chacun une version différente de la même trame. Avec l’histoire d’un gangster londonien retournant chez lui dans le Nord pour venger son frère, Lewis a voulu proposer un thriller qui est aussi, fondamentalement, une réflexion sur les deux types de destins qui attendent les fils d’ouvriers : le prolétaire ou le truand. Hodges, en faisant le choix de supprimer les retours en arrière et la narration en voix off, et en choisissant Michael Caine pour interpréter le rôle central a offert un thriller violent et érotique, centré sur la vengeance. Mais en donnant une grande place à la description de Newcastle, il a aussi proposé une version du film noir fortement teintée de réalisme social. De cette manière Lewis et Hodges construisent donc deux visions du film/roman noir qui ont fait date dans la culture populaire britannique.
Reinventing and shifting lines in Vita Sackville-West’s Passenger to Teheran (1926)
Authors: HAGHSHENAS Leila
Published: December 2024

When, in 1926, the renowned Edwardian poet and novelist Vita Sackville-West (1892-1962) travelled to Iran to visit her husband, Harold Nicolson, who was then serving as a diplomat in Teheran, she could not have imagined how disconnected her image of Persia was from reality. Despite her surprise and disappointment regarding some aspects of the country, Sackville-West’s Passenger to Teheran conveys a fantasized image of Persia. This paper aims to show that her text is influenced by inherited prejudices that are responsible for her picturing Persia as a land of exotic and romantic adventures. Instead of relying on historical facts, she deliberately invites fiction into her travelogue. Hence, despite the linear structure of the travelogue, the writer’s Edwardian representation of Persia is constantly shifted and pushed aside by the reality of life there. Building on Edward Said’s theories, this paper argues that Sackville-West’s subjective approach to her travelogue and her use of fictional elements contribute to the persistence of a mythical image of Persia despite the emergence of shifting lines and reliable information about the country.
Shifting the lines of the British travel writing tradition: Marlow's vertical travel in Lord Jim
Authors: LORÉAL Isabelle
Published: December 2024

The representation of space in Lord Jim was at odds with the expected nineteenth century exotic landscape, posing as a mere backdrop to the adventurer’s feats. Jim's thwarted linear progression also signalled a modern shift in narration placing more emphasis on space and simultaneity than on chronological progress. In travel writing, the concept of “vertical travel” has recently emerged. A slower type of voyage, concerned with the minute details of a particular place, deep diving into the layered strata of its history enables the traveler to discover it anew. I will argue that Marlow's experience in Patusan already corresponds to this type of downwards travel. While the opening of the Suez Canal heralded the end of the period when it was still possible to discover unchartered territories on the surface of the earth, its drilling deep into the ground also signaled that exploration would need to become excavation, uncovering of what is layered stratigraphically under the surface. Conrad's geopoetics recreated space anew in a world with no blank space left to discover and signalled the end of romantic traveling. The deep chasm in the Patusan hills calls for an exploration of the depths as the new frontier for the exotic.
Vernon Lee’s travel essays and the “confusion” of optical and temporal lines
Authors: McKEOWN Claire
Published: December 2024

Vernon Lee’s response to impressionism is mixed, but in Limbo she lauds the impressionist painters’ ability to capture “the confusion of Nature’s effects.” This article builds on the idea of impressionist confusion in Vernon Lee’s travel writing, placing her comments on visual art in parallel with her treatment of place. I attempt to identify the intermedial effects and types of confusion in her texts, which are both optical— mirroring visual art—, and emotional— focusing on her subjective impressions. Her texts play with temporal strata, blending past and present through descriptions of geographical exploration. She also includes a didactic aspect in her texts, aiming to convert her readers to the idea of “sentimental travel,” which focuses on the emotions inspired by places. Reading Lee through impressionism makes it possible to extend the idea of confusion in her texts beyond her reception of impressionism, making it a guiding principle for her representation of travel as a spiritual experience.
Shifting lines in D. H. Lawrence’s travel writings
Authors: GUPWELL Tim
Published: December 2024

D.H. Lawrence (1885-1930) spent much of his life travelling around the globe, at least until his untimely death from tuberculosis. But Lawrence’s travel writing was inextricably linked with his personal philosophy, and one aspect that particularly fascinated Lawrence was the idea of straight lines. In Mornings in Mexico, for example, he makes the startling assertion that “the straight course is hacked out in wounds, against the will of the world”. For Lawrence clearly associated linearity with the scientific, causal thinking of a human world which he detested, and he aimed to develop an alternative model. Thus, he sought to shift from a horizontal axis to a more vertical one (expressed in his own terms, it involves not contenting oneself with exploring the surface, but rather seeking out the hidden depths); hence his interest in crossing “dividing lines”, or “gulfs” or “abysses”, which pushed him indefatigably to pursue new, unpredictable and surprising encounters with people, places and even things. And yet his search for another paradigm led him still further. In Mornings in Mexico Lawrence also wrote the following: “Strange that we should think in straight lines, when there are none, and talk of straight courses, when every course, sooner or later, is seen to be making the sweep round, swooping upon the centre”. Ultimately, a radically non-linear, anti-scientific vision is shown to be at the very heart of Lawrence’s travel writing.
« Retracing our steps » : failles géologiques et défaillances familiales dans Goat Mountain de David Vann
Authors: BOISGERAULT Pauline
Published: December 2024

Figurations de l’instabilité sismique de la Californie, laquelle s’étend en grande partie sur la faille San Andreas, les défaillances déployées dans Goat Mountain de David Vann esquissent une cartographie de ce qui « fait défaut, où elle marque un manque » (Didi-Huberman 88). Amorcé par un retour spatial vers le campement familial, le récit retranscrit le voyage intérieur du narrateur qui revient sur ses pas, et tente d’exhumer, à travers une modalité analeptique, ce qui a pu manquer ou faire défaut. Le texte de Goat Mountain tisse entre elles les fissures métaphoriques et retrace les origines des failles géologiques du lieu, qui recèlent la généalogie défaillante d’un groupe d’hommes qui vit en marge de la société. Le roman de Vann s’évertue à sonder et cerner les origines d’un crime à travers l’exploration des défaillances polymorphes à l’œuvre dans le récit. Le retour sur l’événement préfigure un déferlement de violence, mais concourt avant tout à exposer les fêlures latentes qui menaçaient au préalable la stabilité tellurique et familiale. À travers le voyage analeptique, le texte se fait alors corps défaillant pour tenter de traduire l’indicible, et les manifestations des multiples failles participent à la rémanence d’un passé dont la violence refait irruption dans le présent.
“[C]losure is something I may never obtain”: (In)consolation in Yewande Omotoso’s An Unusual Grief (2022) and Onyi Nwabineli’s Someday, Maybe (2022)
Authors: COURTOIS Cédric
Published: December 2024

Both Yewande Omotoso’s An Unusual Grief (2022) and Onyi Nwabineli’s Someday, Maybe (2022) address the shattering effects of grief after the sudden and tragic loss of a loved one to suicide. They tackle “the ugliness” and “the untidiness” of grief and question the possibility of finding any consolation in this context. First, I analyse the stakes behind both diasporic writers’ exploration of the shattering “desolation” that grief represents, by delving into the formal elements that enable them to articulate desolation and trauma. I then explore issues related to repairing, caring and consoling in both novels by taking a look at the tears that are shed and the modalities of this time of and for consolation, before I finally take a look at the metaphor of excavation as the main characters search for meaning and, possibly, comfort, after the aforementioned loss. The issue of the (im)possibility of “closure” will be raised as the characters’ excavating endeavour aims to “unravel the mystery” of these deaths, notably through working and writing through loss and grief.
Le sens de la rigolade. Du rire et des sœurs, ou la possibilité du féminisme depuis Mes bien chères sœurs chez Chloé Delaume
Authors: Fayolle Azélie
Published: December 2024

Chloé Delaume est un personnage de fiction. Elle est pourtant, alors qu’elle se détourne de l’autofiction pour la fiction, rattrapée par le réel qui la dépasse par l’actualité politique, notamment de #metoo. À partir de Mes bien chères sœurs, c’est ainsi un autre rapport au réel qui se noue dans l’œuvre jusque-là autofictionnelle de Chloé Delaume, au creux même du comique qui caractérise son œuvre. Par la référence à Solanas, la sororité trouve une réalité paradoxale et comique dans une fiction assumée.
Houellebecq et ses histoires de bêtes : vers un épuisement du rire ?
Authors: Rousseau Guillaume
Published: December 2024

Le premier roman de Michel Houellebecq, Extension du domaine de la lutte (1994), frappait par l’humour de ses “fictions animalières”. À l’autre bout de l’œuvre, avec Quelques mois dans ma vie (2023), nous voyons les animaux ressurgir dans un “documentaire animalier” retraçant la participation malheureuse de Houellebecq au porno Kirac 27 de Stefan Ruitenbeek. Par le biais d’une comparaison entre les deux œuvres, le présent article montre comment le motif comique de l’histoire de bêtes se retrouve vidé de sa substance et expose les raisons de cet épuisement du rire.
The Relationality of Collective Property. Commons and Convivial Conservation in Umbria, Italy
Authors: Ravaioli Michele
Published: December 2024

This article, within the field of mountain geographies, proposes a critical analysis of collective property, as a virtuous example of territorial governance, connecting property studies with the concepts of common and convivial conservation. Structuring a series of social relations based on mutual obligations and shared values between community members, within an active participation to the territorial management fostered by the collective status of land property, collective land structures represent peculiar commons that local communities use and take care of. In particular, collective land property and collective territorial management foster convivial conservation processes at the socioecological level, while the implementation of individual private property relations tends to promote uncontrolled phenomena of exploitation of resources and individualistic attitudes. The analysis of the case studies, that are the Umbrian Comunanze Agrarie of Massa Martana and Colpetrazzo, confirms the positive relationality of collective property, counterposed to the socialisation of people and spaces linked to the territorialisation of individual private property, as it allows the maintenance of common goods and spaces which guarantee a direct and democratic territorial governance able to contrast the present socio-environmental challenges.
Enhancing West African family medicine curriculum through entrustable professional activities
Authors: Fatusin Bolatito B. , Dankyau Musa , Essuman Akye , Gyuse Abraham N. , Fatusin Akinfemi J. , Jenkins Louis S.
Published: December 2024

The training of Family Medicine residents in the West Africa College of Physicians (WACP) has steadily upscaled to a competency-based approach over the years. The latest review of the curriculum (2022) includes self-directed online modules on clinical postings, health management, patient safety, quality assurance research and medical education among others. The operationalisation of the revised curriculum involves the use of workplace-based tools for formative assessments. However, some shortcomings of the traditional work place based assessment (WPBA) have been observed, including a lack of standardisation, time consumption, variability in the assessors’ judgements and systematic biases. These shortcomings can be mitigated through the adoption of entrustable professional activities (EPA) along with the use of WPBA.
Immunoinformatic approach to the design of a novel multi-epitope vaccine against Leishmania major fused to human IgG-Fc
Authors: Fadaie Mahmood , Shahmoradi Zabihollah , Khanahmad Hossein
Published: December 2024

Background and purpose:

Cutaneous leishmaniasis poses significant health and socioeconomic challenges, making vaccine development a top priority, especially in endemic regions. Cysteine proteases, KMP-11, and HASPB proteins are promising candidates for leishmaniasis vaccine development owing to their immunogenic properties and capacity to provoke robust immune responses, as evidenced by different investigations. This study aimed to design a recombinant chimeric protein (MEV-Fc) vaccine using multi-epitopes from these Leishmania major proteins.

Experimental approach:

The antigens were subjected to immunoinformatic prediction and screening of HTL, CTL, and B-cell epitopes. The multi-epitope protein was designed with significantly high-scoring epitopes and suitable linkers. Natural adjuvants were then added to enhance immunogenicity. Vaccine potency was innovatively improved by covalently fusing human IgG1 Fc with multi-epitope protein. To investigate how the MEV-Fc vaccine interacts with Toll-like receptors, molecular docking, multi-scale normal mode analysis simulation, and computational immune simulation were employed to study humoral and cellular immune responses.

Findings/Results:

The results demonstrated the vaccine’s antigenicity, stability, and nontoxicity. The structural validation confirmed the accuracy of the 3D models, indicating robust interactions with TLR2 and TLR4, with binding free energies of -1269.9 and -1128.7 (kcal/mol), respectively. Immune simulation results showed significant increases in IgM and IgG antibody levels following three vaccinations, along with enhanced activation of B cells, helper T cells, and cytotoxic T lymphocytes.

Conclusion and implications:

These findings provide novel insights for developing effective candidates for cutaneous leishmaniasis vaccines. However, laboratory experiments are necessary to evaluate its protective effects.
Antiaging properties of chlorogenic acid through protein and gene biomarkers in human skin fibroblast cells as photoaging model
Authors: Girsang Ermi , Ginting Chrismis N. , Lister I Nyoman Ehrich , Widowati Wahyu , Yati Afif , Widya Kusuma Hanna Sari , Azis Rizal
Published: December 2024

Background and purpose:

Chlorogenic acid (CA) is a natural chemical that promises antiaging activity against photoaging skin damage. This research examined CA activities in mitigating skin photoaging.

Experimental approach:

UV-exposed human skin fibroblast cells were subjected to CA at 6.25, 12.5, and 25 μg/mL. The protein levels of cell secretion, such as cyclooxygenase (COX)-2, nitric oxide (NO), and interleukin (IL)-6 were measured using ELISA and colorimetry methods. Meanwhile, the mRNA expressions of glutathione peroxidase (GPX)-1, tissue inhibitor metalloproteinase (TIMP)-1, matrix metalloproteinase (MMP)-1, caspase (CASP)-3, CASP-8, and fibroblast growth factor (FGF)-2 were quantified using the qRT-PCR method.

Findings/Results:

CA treatment reduced inflammatory and aging biomarkers. CA at 6.25 μg/mL lowered NO, COX-2, and IL-6 levels to 89.44 μmol/L, 8.10 ng/mL, and 62.75 pg/mL, respectively. CA at 25 μg/mL resulted in the most significant down-regulation of MMP-1, CASP-3, and CASP-8 genes’ expression (3.27, 1.25, and 3.59, respectively). Furthermore, treatment with CA at 25 µg/mL demonstrated the most notable activity in up-regulating antioxidant markers, specifically GPX-1, and extracellular matrix (ECM) integrity markers, including TIMP-1 and FGF-2 genes’ expression.

Conclusion:

CA imposes its anti-aging activity by decreasing inflammatory and aging biomarkers, and increasing cellular antioxidant and ECM integrity.
Enhancement effect of urea toward electroporation-mediated plasmid transfection efficiency in the HEK-293 cell line
Authors: Mowla Mahshid , Gorji-Bahri Gilar , Moghimi Hamid Reza , Hashemi Atieh
Published: December 2024

Intracellular delivery is crucial in biological and medical studies. Although many molecular tools have been created for cell-based gene therapies, it remains challenging to introduce external molecules into cells. As one of the most popular non-viral transfection methods, electroporation induces transient pores in the cell membrane by applying an external electric field. Unsatisfactory transfection efficiency and low cell viability are the major drawbacks of electroporation. To overcome these issues, the current study investigated the effect of urea on electroporation-mediated transfection efficiency.

Experimental approach:

Three voltages of electroporation, including 100, 120, and 140 V, and 3 concentrations of urea buffer, including 0.25%, 0.5%, and 1% W/V, were considered as variables in this study. The HEK-293 cell line was used for transfection, and green fluorescent protein (GFP) expression was evaluated using flow cytometry and fluorescence microscopy.

Findings/Results:

The results showed that the combination of electroporation and urea increased electroporation efficacy, but the effect depended on voltage and urea concentration. When different concentrations of urea were added to HEK-293 cells at a voltage of 100 V, the number of cells transfected by pEGFP-N1 increased (from 12.3 ± 0.2% in untreated cells to 17.35 ± 0.55%, 23.3 ± 0.3%, and 14 ± 0.1% at urea concentrations of 0.25%, 0.5%, and 1% W/V, respectively). The electroporation buffer containing 0.5% W/V urea showed the highest EGFP expression (23.3 ± 0.3%) and high cell viability (over 90%).

Conclusion and implications:

This research offers a new perspective for improving gene transfection efficiency once electroporation is utilized.
Multiple ligands simultaneous molecular docking and dynamics approach to study the synergetic inhibitory of curcumin analogs on ErbB4 tyrosine phosphorylation
Authors: Aman La Ode , Ischak Netty Ino , Tuloli Teti Sutriyati , Arfan Arfan , Asnawi Aiyi
Published: December 2024

Background and purpose:

Lapatinib (FMM) and 5-fluorouracil (5-FU) are anticancer drugs employed in a combination approach. FMM inhibits tyrosine phosphorylation of ErbB4 while 5-FU inhibits cell proliferation. This research aimed to investigate the potential of two compounds, namely (1E,4E)-1,5-bis (4-hydroxyphenyl) penta-1,4-dien-3-one (AC01) and (1E,4E)-1,5-bis (3,4-dihydroxy phenyl) penta-1,4-dien-3-one (AC02), both as individual inhibitors and combination partners with FMM, targeting ErbB4 inhibition. AC01 and AC02 were combined with FMM, which targets ErbB4. The combination of 5-FU with FMM served as a reference in this study.

Experimental approach:

The research utilized computational simulation methods such as single and multiple ligands simultaneously docking and dynamics. Data analysis was performed using AutoDockTools and gmx_MMPBSA.

Findings/Results:

Single docking results indicated that 5-FU exhibited the lowest binding affinity, while FMM demonstrated the highest. Simultaneous docking of AC01 and AC02 paired with FMM revealed their binding positions overlapping with the FMM-5-FU workspace. The FMM-AC01 and FMM-AC02 complexes exhibited slightly weaker binding affinities compared to FMM-5-FU. In combination with FMM, AC01 and AC02 occupied the ErbB4 activation loop, whereas 5-FU was outside the activation loop. Furthermore, in their interaction with ErbB4, AC02 exhibited slightly stronger binding than AC01, as confirmed by the average binding free energy calculations from molecular dynamics simulations.

Conclusion and implications:

In conclusion, computational simulations indicated that both AC01 and AC02 have the potential to act as anticancer candidates, demonstrating ErbB4 inhibitory potential both as individual agents and in synergy with FMM.