bluuebunny/crossref_metadata_2025 huggingface dataset:
A COMPARATIVE STUDY OF REDUCED PORT SIZE MINILAPAROSCOPIC CHOLECYSTECTOMY (MLC) VERSUS STANDARD FOUR
PORT CONVENTIONAL LAPAROSCOPIC CHOLECYSTECTOMY (CLC).
Authors: Sharma Anil Kumar , Jangid Lal Chand , Bhadauria Nagendra Singh , Singh Amit
Published: February 2021

Background: Reduced port size mini-laparoscopic cholecystectomy (MLC) has widened the horizons of modern
laparoscopic surgery. Standard four port conventional laparoscopic cholecystectomy (CLC), which has long been
established as the “Gold Standard” for gall bladder diseases, is under reconsideration following the advent of further minimally-invasive
procedures including MLC. Our study aims to provide a comparison between MLC and CLC and assesses whether MLC has any added benets.
Materials And Methods: A prospective randomized controlled study of 46 patients of gall stone disease was conducted at J.L.N. Medical
College, Ajmer. The patients assigned in to two groups (23 in each) group A [Reduced port size mini-laparoscopic cholecystectomy {MLC}] or
group B [Standard four port conventional laparoscopic cholecystectomy {CLC}] through randomization. Data was collected prospectively and
analysed retrospectively using a predesigned Performa.
Results: In our study, both the groups had similar age, body mass index (BMI) and gender distribution. No cases of MLC required insertion of
additional ports. The mean operative time for MLC was 63.74 ± 9.50, which is longer than CLC 44.91 ± 14.73. The pain was signicantly lower
in mini laparoscopic group which is analysed on 0th ,2nd 7th and 28th post operatively. Patients who underwent MLC were able to return to
normal activity earlier than patients undergoing CLC (P < 0.01).
Conclusion: Our experience suggests that MLC can safely be used as an alternative to CLC. Compared to CLC, it has the added benet of an
early return to work along with excellent cosmetic results. Intraoperative blood loss is comparable in both groups, however the operative time in
MLC group higher than the CLC group. Further large scale trials are required to prove any additional benet of MLC
DIAGNOSIS OF EISENMENGER SYNDROME IN PREGNANCY:
THERAPEUTIC CHALLENGES FACED DURING MANAGEMENT OF A
COUPLE WITH PRECIOUS CONCEPTION
Authors: Kumar Abhay , Sarkar Avir
Published: February 2021

Eisenmenger Syndrome poses a hemodynamic overload and additional burden for the already compromised right
ventricle. It causes right to left shunt thereby exaggerating central cyanosis, leading to various sequelae in the form of
abortion, preterm labor and intrauterine fetal growth restriction. Vasodilators in the form of intravenous prostacyclin, phosphodiesterase inhibitors
like sildenal and tadalal and inhaled nitric oxide during second stage of labor have been successfully used. Pregnancy is ideally contraindicated.
Those continuing pregnancy must be adequately supervised by an experienced multidisciplinary team. Termination of pregnancy is done by
Caesarean. Epidural analgesia is preferred.
COMPARATIVE HEMATOLOGICAL STUDY OF TYPE 2 DIABETIC AND
NON-DIABETIC PATIENTS IN ERODE DISTRICT, TAMIL NADU
Authors: Thinakaran Murugesan , Chitra Thangadurai
Published: February 2021

Background And Objectives: Previous studies have shown that hematological alterations are a common nding in
patients with diabetes. To aim of our study was to explore the hematological indices in type 2 diabetic patients compared
with non-diabetic individual. Establish the role of haematological parameters as an early prevention strategy.
Materialand Method: Two hundred and forty-six subjects were recruited for this study, one hundred and fourteen with type 2 diabetes and One
hundred and thirty-two non-diabetes, were evaluated for haematological parameters using hematologic analyzer. All the information's about the
disease was collected with the knowledge of the patients form the concern hospital and laboratory.
Results And Conclusions: Results were compared with the same measurements in 132 subjects without diabetes mellitus. The haematological
prole associated with Type2 diabetic patients signicantly reduced Hb, RBCs, PCV and MCV than Non diabetes. Increased MCHC and WBCs
were noted in Type2 diabetes. Our ndings suggest the need of screening for routine hematological tests in type 2 diabetes mellitus
'EUTHANASIA': AN ACT OF PERFORMANCE UNDER THE PURVIEW OF
ETHICAL AND CONSTITUTIONAL ASPECTS
Authors: Mukhopadhyay Swarnali
Published: February 2021

'Euthanasia' is the most debatable issue and has been a burning topic all over the world. The word 'Euthanasia' has been
derived from Greek word 'Eu' means 'goodly' or 'well' and 'Thanatos' means 'death'. The lexicographical meaning of the
word 'Euthanasia' is 'mercy killing' in which the intentional termination of the life of a terminally ill person is carried out by the assistance of
another person. It is a process of carrying out a gentle and easy death of a terminally ill person when his death is desired to free him from his terribly
painful life. 'Euthanasia' generally can happen in two ways – i. Passive Euthanasia and ii. Active Euthanasia. In Passive Euthanasia, the treating
doctors withdraw life-support machines or withhold any further treatment to shorten the life of a dying person. In Active Euthanasia, the treating
doctors apply overdose of painkillers or some other medications to quicken the death of a dying person. Some countries have legalized passive and
some have legalized active euthanasia under certain legal guidelines. In this article, the subject of euthanasia has primarily been discussed from
the perspective of its righteousness under the constitutional laws and its enshrinement. I also intended for a debate on the preference of active
euthanasia over the passive euthanasia for quickening the death of a terminally ill person.
A PROSPECTIVE COMPARITIVE STUDY OF APACHE II AND APACHE IV IN
MORTALITY PREDICTION IN ICU
Authors: Kavitha R , Mayi Kiran
Published: February 2021

Various scoring systems have been developed to predict mortality and morbidity in intensive care unit, but different data
has been reported so far. To compare the predicted mortality of APACHE II and AP Aims: ACHE IV. This Methodology :
prospective study was conducted in 12 bed ICU center in our hospital. 57 patients were taken with age group of above 15years irrespective of
diagnosis, managed in ICU for >24hrs . APACHE II and APACHE IV scores were calculated based on the worst values of the rst 24 h of
admission. All enrolled patients were followed during their ICU stay Or till death and outcome was recorded as survivors or non survivors.
Results : There were 40 survivors .In APACHE II the mean score for survivors was 16.39 ± 6.82, which was less compared to mean the score
of 22.08 ± 7.18 for non survivors. (P = 0.001).In APACHE IV the mean score for the survivors was 83.96 ± 17.93, which was less compared
with mean the score of 107.44 ± 21.53 for non survivors.(P < .001) Conclusion: Discrimination, was fair for both models, but APACHE IV was
superior to APACHE II. Calibration, was better for APACHE II than APACHE IV in our ICU. There was good correlation observed between the
models.
Pengaruh Kepemimpinan Transformasional Dan Kompetensi Terhadap Kinerja Karyawan
Authors: Yanti Dyah Agustin Widhi , Mursidi Mursidi
Published: February 2021

Running a business requires accuracy and speed from the operational process to the process of delivering goods to consumers. This development is supported by the ease of delivery of goods, both from producers to consumers. Goods can be shipped by land, sea, and air shipping. This is a business opportunity for business people who have a strategic location for the delivery route. This study uses a quantitative approach, by collecting data through surveys. Transformational leadership has a significant effect on the performance of employees of PT. Surabaya Container Terminal. Transformational Leadership of PT. The strong Surabaya Container Terminal will have an impact on employee performance. This is due to the application of idealized influence, the behavior of a leader that makes his followers admire, respect, and trust him. Competency results have a significant effect on the performance of employees of PT. Surabaya Container Terminal. This means that competence can improve employee performance.
ANALISIS KEBIJAKAN PEMUNGUTAN RETRIBUSI PELAYANAN PERSAMPAHAN KEBERSIHAN DALAM RANGKA PENINGKATAN PENDAPATAN ASLI DAERAH DI KOTA BANDAR LAMPUNG
Authors: RA Pertiwi Agustina , Marpaung Lintje Anna , Ningrum Herlina Ratna Sumbawa
Published: February 2021

The policy of the collection of hygiene waste service in order to increase the regional genuine income has been implemented but not maximally. The implementation is done by planning, implementing a means or a work device that facilitates the implementation of the collection of waste services effectively and efficiently and implement the mechanism of retribution and implement a clear evaluation system. The inhibitory factors of the implementation of the collection of waste services/hygiene is still low understanding of the subject of retribution of local legal products concerning the levy of waste services/hygiene and still low awareness of the subject of retribution to the levy which is considered to be incriminated due to feel the obligation of paying tax to Bandar Lampung city government.
PENERAPAN PERJANJIAN KERJA ANTARA DIREKTUR DAN KARYAWAN TERKAIT DENGAN ASAS KEBEBASAN BERKONTRAK BERDASARKAN PASAL 1320 KITAB UNDANG-UNDANG HUKUM PERDATA
Authors: Sukardi Dina Haryati , Herlambang Dian
Published: February 2021

The principle of freedom of contract is a principle that gives freedom to the parties to: (1) make or not make an agreement; (2) entering into agreements with anyone; (3) determine the contents of the agreement, implementation, and terms; and (4) determine the form of an agreement that is written or oral. The purpose of this study is to find out whether the work agreement between directors and employees at the Hospital of Menggala based on the principle of freedom of contract is in accordance with Article 1320 of the Civil Code, knowing the inhibiting factors in the implementation of the principle of freedom contracting to an employment agreement at the District Hospital ofalaala, and the efforts made in overcoming any obstacles that occur in the implementation of the principle of freedom of contracting with an employment contract at the District Hospital.The results of the analysis carried out that the work agreement of the Cooperative Hospital meets the principle of freedom of contract. The principle of freedom of contract is a principle that gives freedom to the parties to make or not make an agreement, enter into an agreement with anyone, determine the contents of the agreement, its implementation, requirements, determine the form of the agreement, written or oral, in making the work agreement of both the Directors and workers there is no influence or pressure from the other party, both parties give freedom to the other party to express their opinions or proposals regarding the agreement material, then the work agreement of the Shepala Regional Hospital is in accordance with the principle of freedom of contract as contained in Article 1320 of the Civil Code. In carrying out the principle of freedom of contract beer to work agreements the Cooperative Hospital experienced obstacles. Constraints faced include: (1) the absence of trade unions in fighting for workers' rights (2) Low Worker Resources. The efforts of the Penggala District Hospital in facing obstacles in implementing the principle of freedom of contract to work agreements are immediately possible to form trade unions that can bridge workers and hospital directors and hold various trainings to improve the professionalism and abilities of their employees.
EXISTENCY ROLE OF THE GENERAL ELECTION SUPERVISORY AGENCY IN LAMPUNG LAW ENFORCEMENT OF THE 2019 ELECTION
Authors: Maimun Maimun , Santoso Rudi
Published: February 2021

The Lampung election supervisory body has performed its role effectively byprocessing these findings and reports. Although, in the process, only one criminal case reached a trial and was decided by the Court. The Lampung general election supervisory body has a number of obstacles faced in prosecuting 2019 Election violations. These include the inadequate role of the Integrated Law Enforcement Center (Gakkumdu). This is due to differences in backgrounds and good views between the General Election Supervisory Agency, the Police and the Attorney General's Office in observing cases of election violations. Another factor is Human Resources. Human resources owned by the General Election Supervisory Agency are still very few, coupled with the number of budgets and inadequate facilities. In the process, only one criminal case has reached trial and is decided by the Court. The Lampung general election supervisory agency has a number of obstacles faced in prosecuting 2019 Election violations. These include the inadequate role of theIntegrated Law Enforcement Center (Gakkumdu). This is due to differences inbackgrounds and good views between the General Election Supervisory Agency, the Police and the Attorney General's Office in observing cases of election violations. Another factor is Human Resources. Human resources owned by the General Election Supervisory Agency are still very few, coupled with the number of budgets and inadequate facilities. In the process, only one criminal case has reached a trial and is decided by the Court. The Lampung general election supervisory agency has a number of obstacles faced in prosecuting 2019 Election violations. These include the inadequate role of the Integrated Law Enforcement Center (Gakkumdu).
IMPLEMENTATION OF ARTICLE 3 LAW NUMBER 4 OF 2009 CONCERNING MINERAL AND COAL MINING IN THE GRANTING OF EXPLORATION MINING BUSINESS LICENSE
Authors: Anggalana  , Putra Dery , Reformasi Chandra
Published: February 2021

Indonesia is a country rich in natural resources. Therefore, the Government isexpected to be able to manage these natural resources with the aim of people's welfare in accordance with the mandate of the Constitution of the Republic of Indonesia 1945 as stipulated in Article 33 paragraph (3) which reads "The Earth, water and natural resources contained therein are controlled by the state and used for the greater prosperity of the people ". Article 3 of Law Number 4 Year 2009 concerning Mineral and Coal Mining provides guidelines for the government in the implementation of mining business activities and to support the implementation of licensing of mining business activities. The issue of how to implement the granting of exploration mining business licenses based on Article 3 of Law No. 4 of 2009 on Mineral and Coal Mining in Lampung Province and how to supervise mining business activities in Lampung Province. The method used uses normative and empirical juridical research. The implementation of the granting of exploration mining business licenses based on Article 3 of Law No. 4 of 2009 on Mineral and Coal Mining in Lampung Province has been running but not yet maximal because the permit process is too long so that the purpose of the implementation of mining business activities is not achieved. The suggestion is that the license for exploration mining activities must be carried out by one government agency / agency, in order to facilitate the process of obtaining the permit in order to support the effectiveness of mining activities and the cycle of domestic mining investment, especially in Lampung Province.
SENSIBILIDADE DE Aspergillus sp. E Fusarium sp. A DIFERENTES CONCENTRAÇÕES DE FUNGICIDAS
Authors: Chaves Neto José Roberto , Boscaini Ricardo , Francisco Dressler da Costa Ivan
Published: February 2021

A principal estratégia de controle das doenças relacionadas aos grãos e espigas na cultura do milho é a aplicação de fungicidas. No entanto, ao longo dos últimos anos vem ocorrendo o desenvolvimento de maior resistência dos fungos perante as moléculas químicas. Com isso, a determinação in vitro de espécies resistentes a estes produtos possibilita o desenvolvimento de novas formas de controle. O objetivo deste trabalho foi avaliar a sensibilidade in vitro dos fungos Aspergillus sp. e Fusarium sp. a diferentes fungicidas. Foram avaliados os fungicidas Epoxiconazol + Piraclostrobina, Ciproconazol + Picoxistrobina e Fluxapiroxade + Piraclostrobinal nas concentrações de 0, 10, 50, 100, 500, 1000 ppm, sob delineamento inteiramente casualizado, em arranjo fatorial, com quatro repetições. Determinou-se a porcentagem de inibição de crescimento micelial, o índice de velocidade do crescimento micelial e a concentração de cada fungicida capaz de inibir 50% do crescimento micelial (IC50). De modo geral, quanto maior a concentração do fungicida utilizado maior foi a porcentagem de inibição e menor índice de velocidade média de crescimento micelial dos fungos Aspergillus sp. e Fusarium sp. Para o fungo Aspergillus sp., o fungicida Fluxapiroxade + Piraclostrobina proporcionou o menor crescimento micelial com a IC50 de 39,78 ppm. Já para o fungo Fusarium sp., o menor crescimento micelial foi observado com o fungicida Epoxiconazol + Piraclostrobina na IC50 de 25,56 ppm.
APLICAÇÃO DE BIOESTIMULANTE E COMPLEXO DE NUTRIENTES NO TRATAMENTO DE SEMENTES DE SOJA
Authors: PEREIRA DOS SANTOS LUANA , RIBEIRO BARBACENA DANILO , Cavalcante Gonçalves Rogério , AUGUSTO COSTA NASCIMENTO CÉSAR , Leal de Castro Carvalho Fredson , Cardoso França Luciano , Adorian Gentil Cavalheiro
Published: February 2021

Novas tecnologias vêm sendo empregadas com o intuito de maximizar a produção vegetal da cultura da soja (Glycine max L.). Assim, neste artigo, objetivou-se avaliar a influência do tratamento de sementes com produtos bioestimulantes e a suplementação com complexos de nutrientes para a obtenção de um melhor percentual de emergência e do aumento do crescimento inicial da soja. Os experimentos foram realizados no laboratório e na casa de vegetação do Centro Universitário Católica do Tocantins, Unidade de Ciências Agrárias e Ambientais, em Palmas – TO. Os tratamentos consistiram em:  (i) T1 - Tratamento de sementes com produto Stimulate® (produtos à base de fitorreguladores); (ii) T2 - (a base de macro e micronutrientes); (iii) T3 - aplicação em conjunto (Stimulate® + Raiz®) e, (iv) T4 - sem tratamento (Testemunha), com cinco repetições para cada tratamento. Avaliou-se a porcentagem de germinação (%) e as avaliações de comprimento da radícula (cm) e do hipocótilo (cm) ao oitavo dia de implantação do experimento em laboratório e, em casa de vegetação, foram realizadas as avaliações de altura das plantas (cm), comprimento da raíz (cm), diâmetro do caule (mm), massa seca da parte aérea (g) e massa seca da raiz (g), aos 41 dias. Os dados foram submetidos à análise de variância (Teste F) e ao teste de Tukey a 5% de probabilidade. Não houve diferença significativa no percentual de germinação, comprimento do hipocótilo, altura da planta, comprimento da raiz e massa seca da parte aérea. Para as avaliações de laboratório, a aplicação conjunta de Stimulate® + Raiz® influenciaram positivamente no comprimento radicular.  Para as avaliações em casa de vegetação, destacaram-se os tratamentos com Stimulate® e a aplicação conjunta Stimulate® + Raiz no diâmetro do caule e matéria seca da raiz, respectivamente.
An overview of Impact of Geopathic Stress on Environment and Human Health
Authors: Tong Eng Siang , Kong Chee Kei
Published: February 2021

Earth’ core is dynamic and always fluctuating by the natural variations in its rotation, creating a massive energy field, known as electromagnetic field (EMF). We are continuously exposed to a wide spectrum of electromagnetic radiation from both natural and artificial sources which have adverse effects on the subtle balance in nature's energy fields. Natural geopathic stressors include geological faults, geomagnetic anomalies, ley lines crossing, radon gas and underground water courses. The affected geographical locations are known as geopathic stress zones as these locations exert negative effects upon health. Geopathic stress can affect all living beings including humans, animals and plants. It is primarily associated with sick building syndrome, potentially lead to physical and mental illnesses. It may also cause pavement distress, as well as frequent machinery broke down. Energy from the subsurface of the earth at specific locations or in a built environment can be detected by using ancient techniques like dowsing, and modern devices such as Spinning Electric Vector Analyzer (SEVA) and gas discharge visualization (GDV) camera, as well as tests like Vegetative Resonance Test (VRT) and Light Interference Technique (LIT). It is important that one's bed or workstation is located on a geopathic stress free zone. There is much that can be done to ameliorate or remove geopathic stress, such as ‘Feng Shui’, Earth acupuncture, and various other modern Western methods. This paper aims to discuss the potential impact of geopathic stress on the living environment and human health.
Problems of legal qualification in private international law: doctrine, case law and Ukrainian law
Authors: Perestiuk Natalia
Published: February 2021

In this paper, the author observes the historical origins and development of doctrines of qualification (characterization) in private international law. Analyzing different approaches as to the place of qualification in the process of operation with a choice-of-law rule, as to its scope and subject, as well as to the distinction between qualification and interpretation processes, the author concludes on the controversial nature of this issue, as well as of the alternative views on the qualification subject and approaches to qualification that may be followed by a judge. Considering current Ukrainian private international law act within the context of alternative approaches to qualification (characterization), the author recognises valuable contribution of its Article 7, arguing that it is exactly a function embodied into a foreign law institute should be treated as a point of synchronization with the relevant choice-of-law rule of the forum. And the role of the case law the author sees as a decisive in the course of such approach implementation.
An attempt of defining Ethnic Minorities for their better protection
Authors: Krivokapić Boris , Sałkiewicz-Munnerlyn Ewa
Published: February 2021

Although the problem of defining ethnic (national) minorities has been written in a lot, it has not been resolved to this day. In that respect, after pointing out that it is more correct to speak about ethnic minorities than national minorities, the article gives an overview of the most important attempts to give an abstract definition of ethnic minorities, which would apply to all cases. Noting that there is still no generally accepted definition of these groups, the article offers explanation of why this is so. After that nine characteristics of ethnic minorities are identified, with the belief that they are at the same time the most important elements for defining these groups. The article points out that various definitions are possible, for various needs. Then a comprehensive general (abstract) definition of ethnic minorities is offered with the belief that it he can serve in most cases.
Significance of a polymerase chain reaction method in the detection of Clostridioides difficile
Authors: Jaqueti Aroca Jerónimo , Molina Esteban Laura M. , García-Arata Isabel , García-Martínez Jesús , Cano De Torres Isabel , Prieto Menchero Santiago ,   Laboratorio Clínico. Hospital Universitario de Fuenlabrada. Madrid
Published: February 2021

Objectives. Clostridioides difficile (CD) is the most common cause of nosocomial diarrhea. Detection of CD toxin in patients’ faecal samples is the traditional rapid method for the diagnosis of CD infection. Various testing algorithms have been proposed: an initial screening test using a rapid test, and a confirmatory test (cytotoxicity neutralization assay, toxigenic culture, nucleic acid amplification test) for discordant results. The aim of this study was to evaluate the effectiveness of a two-step algorithm using an immunochromatographic test followed of a polymerase chain reaction (PCR). Material and methods. The specimens have been tested according to the following schedule: 1) Step one: All samples were tested for detection of glutamate dehydrogenase antigen (GDH) and toxin A/B using the C. diff QUIK CHEK Complete test. All GDH and toxins positive results were considered CD positives; 2) Step two: When the results were discrepant (only GDH+ or toxins+), the samples were confirmed using the PCR test BD MAX Cdiff. All PCR positive results were considered CD positives. Results. A total of 2,138 specimens were initially tested. 139 were positive for GDH and toxins. 160 discrepant results (148 GDH+ and 12 toxins+) were tested by PCR, 117 were positive (107/148 GDH+ and 10/12 toxins+). Conclusions. The implementation of a PCR method showed an increase de 117 positive results (73.1% of discrepant). Considering the sensitivity of C.diff QUIK CHEK (instructions of manufacturer), the GDH discrepant results may be false negatives, y the samples PCR and toxins positives may be real positives results.
Tambang Pasir dan Dampak Sosial Ekonomi Masyarakat di Pesisir Pantai
Authors: Anggariani Dewi , Sahar Santri , Sayful M.
Published: February 2021

Secara umum, pembangunan infrastruktur dimaksudkan untuk lebih meningkatkan kesejahteraan bagi masyarakat. Namun apabila mengabaikan aspek studi kelayakan dan analisis dampak lingkungan, maka akan berpotensi menciptakan kerusakan ekologi maupun ekonomi dan sosial budaya masyarakat setempat. Oleh karena itu, penelitian ini bertujuan untuk mengetahui landasan kebijakan, juga untuk mengetahui dampak sosial dan ekonomi dari keberadaan tambang pasir terhadap masyarakat Galesong. Penelitian ini menggunakan bentuk studi mikro demografi atau biasa disebut quasi anthropological. Penelitian ini dilakukan di wilayah pesisir pantai Galesong. Analisis data dalam penelitian ini dilakukan secara kualitatif. Hasil penelitian menunjukkan bahwa aktivitas penambangan pasir di wilayah pesisir pantai Galesong dimulai pada Tahun 2017 sehingga belum mengacu pada Perda Sulsel No. 2 Tahun 2019, dimana sebagai acuan untuk mengeluarkan izin lokasi dan izin pengelolaan pertambangan pasir di Sulawesi Selatan. Adapun dampak dari aktivitas penambangan pasir terhadap kondisi sosial ekonomi masyarakat di wilayah pesisir pantai Galesong, antara lain hilangnya wilayah penangkapan ikan akibat pengerukan pasir laut, menyebabkan air menjadi keruh. Selain itu, terjadi perubahan sosial ekonomi, dimana para nelayan kecil harus meninggalkan aktifitasnya dan bergabung dengan para nelayan penangkap ikan di laut dalam dan menjadi sawi pada punggawa perahu-perahu besar. Dampak selanjutnya adalah adanya patroli polisi laut yang membuat para nelayan merasa tertekan dan tidak lagi memiliki kebebasan untuk melaut seperti dulu kala. Dengan dasar kesimpulan tersebut, diharapkan Pemerintah Daerah membuat model kebijakan dalam pengelolaan aktivitas penambangan pasir di wilayah pesisir pantai Galesong. Jika tidak, cepat atau lambat masalahnya akan semakin membesar.
Children’s problem solving skills: Does Drama Based Storytelling Method work?
Authors: Kayılı Gökhan , Erdal Zeynep
Published: February 2021

In this research, it was aimed to investigate The Effect Of Problem Solving Training Provided By The Drama Based Storytelling Method on the problem solving skills of five-year-old children. The research is designed according to quasi-experimental model which is one of the quantitative research methods. In the research, semi-experimental design with pretest-posttest control group was used. A total of 40 children, including 20 children in the experimental group and 20 children in the control group, were included in the research. In addition to the Turkey Ministry of National Education Preschool Education Program, children who constitute the experimental group have been given problem solving training with The Drama Based Storytelling Method for a total of 7 weeks, 2 days a week and 1 hour. The children in the control group were not included in this education, but continued their daily education programs only using the Ministry of Education Preschool Education Program currently implemented. The problem solving skills of the children participating in the research were evaluated with The Scale of Problem Solving Skills. The test were applied to children before and after the intervention period; In addition, it was reapplied to the experimental group after 2 weeks. As a result of the research, it can be said that the problem-solving education provided with The Drama Based Storytelling Method, which is implemented in integration with the Ministry of National Education Preschool Education Program, has contributed positively to the problem-solving skills of five-year-old children.
Non-invasive detection of epithelial mesenchymal transition phenotype and metastatic dissemination of lung cancer by liquid biopsy
Authors: De Rosa Viviana , Fonti Rosa , Del Vecchio Silvana , Iommelli Francesca
Published: February 2021

The occurrence of phenotype switch from an epithelial to a mesenchymal cell state during the activation of the epithelial mesenchymal transition (EMT) program in cancer cells has been closely associated with the generation of invasive tumor cells that contribute to metastatic dissemination and treatment failure. Liquid biopsy represents an emergent non-invasive tool that may improve our understanding of the molecular events leading to cancer progression and initiating the metastatic cascade through the dynamic analysis of tumor-derived components isolated from body fluids. The present review will primarily focus on the applications of liquid biopsy in lung cancer patients for identifying EMT signature, elucidating molecular mechanisms underlying the acquisition of an invasive phenotype and detecting new targets for therapy.
Immunotherapy in gynecological cancers
Authors: Lorusso Domenica , Ceni Valentina , Daniele Gennaro , Pietragalla Antonella , Salutari Vanda , Muratore Margherita , Nero Camilla , Ciccarone Francesca , Scambia Giovanni
Published: February 2021

Immunotherapy has changed the natural history of several malignancies that, a decade ago, had a very poor prognosis, such as lung cancer and melanoma. Consequently, many attempts have been done to expand the indications of immunotherapy agents, predominantly immune checkpoint inhibitors (ICIs), in other cancers, including gynecological malignancies. Alongside promising results in cervical and endometrial neoplasms, there are not clear data on the benefit of ICIs as single agent or in combination with antiangiogenic agents in ovarian cancer (OC) and ongoing trials are focusing on combining ICIs with standard chemotherapy or PARP inhibitors. This chapter summarized the evidences of ICIs in gynecological malignancies and report the ongoing trials in cervical, endometrial and OC.
ПРО СТАН ВИКОНАННЯ НАПН УКРАЇНИ РЕКОМЕНДАЦІЙ СЛУХАНЬ У КОМІТЕТІ ВЕРХОВНОЇ РАДИ УКРАЇНИ З ПИТАНЬ ОСВІТИ, НАУКИ ТА ІННОВАЦІЙ НА ТЕМУ: «РЕФОРМУВАННЯ СПЕЦІАЛЬНИХ ЗАКЛАДІВ ОСВІТИ УКРАЇНИ ТА СТАН ВПРОВАДЖЕННЯ ІНКЛЮЗИВНОЇ ОСВІТИ: ПРОБЛЕМИ І ШЛЯХИ ЇХ ВИРІШЕННЯ»
Authors: Кремень Василь Григорович
Published: February 2021

У виступі представлено науковий доробок вчених Інституту спеціальної педагогіки і психології імені Миколи Ярмаченка НАПН України щодо наукового, методичного та психологічного супроводу освіти дітей з особливими потребами на виконання Рекомендацій слухань у Комітеті Верховної Ради України з питань освіти, науки та інновацій на тему: «Реформування спеціальних закладів освіти України та стан впровадження інклюзивної освіти: проблеми і шляхи їх вирішення». Окреслено основні проблеми та завдання, які потрібно вирішувати в контексті поступу освітньої галузі і її доступності для осіб з особливими потребами.
Prueba 7
Authors: Martí Ronda
Published: February 2021

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Karla Xiomara Luna Mariscal, El motivo literario en “El Baladro del sabio Merlín” (1498 y 1535), Ciudad de México, El Colegio de México, 2017
Authors: Domínguez Muñoz Pablo
Published: February 2021

Reseña del libro: Karla Xiomara Luna Mariscal, El motivo literario en “El Baladro del sabio Merlín” (1498 y 1535), Ciudad de México, El Colegio de México, 2017.
Filologia e cultura epica: il caso dei trobadores
Authors: Marcenaro Simone
Published: February 2021

Alcune cantigas de escarnio e maldizer del trovatore galego-portoghese Fernan Soarez de Quinhones alludono, in forma parodica e burlesca, alla letteratura epica, sia attraverso l’uso di forme e stilemi propri del genere, sia attraverso una rete di rimandi intertestuali. L’analisi e lo studio dei possibili intertesti utilizzati dal trovatore per le sue canzoni satiriche possono dirci qualcosa di più in merito alla cultura letteraria del circolo di autori che si riunirono alla corte del futuro Alfonso X, ancora infante, nel quarto decennio del XIII secolo; allo stesso tempo, sarà possibile fornire dati utili sull’influsso dell’epica antico-francese nell’Iberia medievale.
La Historia de Inglaterra de Rodrigo de Cuero: fuentes y elaboración
Authors: Contreras Martín Antonio , Soriano Robles Lourdes
Published: February 2021

La Crónica de Inglaterra de Rodrigo de Cuero es una traducción de la Cronycle of Englonde with the Fruyte of Tymes realizada a instancias de Catalina de Aragón, reina de Inglaterra, en 1509. Mandada completar por ésta hasta su llegada a Inglaterra, el traductor tuvo que echar mano de las fuentes más diversas. El trabajo analiza, en primer lugar, qué fuentes empleó Rodrigo de Cuero para la elaboración de su obra; en segundo lugar, se ocupa de cómo organizó el material y confeccionó las dos versiones conservadas (manuscritos Escorial y Salamanca); y, en tercer y último lugar, se centra en el tratamiento de los reyes ingleses anteriores a Enrique VIII y Catalina de Aragón (Enrique VI, Eduardo IV, Eduardo V, Ricardo III y Enrique VII).
El corpus medieval de la lírica popular catalana con voz femenina
Authors: Mérida Jiménez Rafael M.
Published: February 2021

El presente trabajo tiene como objetivo analizar la presencia de la voz femenina en el corpus de la lírica popular catalana de la Edad Media. Con tal propósito, y tras presentar los resultados de las líneas de investigación principales en el área románica, se estudiará el Corpus d’antiga poesia popular de Josep Romeu i Figueras y serán comentadas las características temáticas y formales de este conjunto formado por veinticuatro poemas. Por último, se propone la inclusión de tres piezas adicionales, de origen diverso, que nos permitirán reflexionar sobre cuestiones relacionadas con sus tipologías textuales, culturales y lingüísticas.
Enrique de Villena y Curial e Güelfa
Authors: Soler Abel
Published: February 2021

Enrique de Villena (1384-1434), noble aficionado a las letras, autor bilingüe en catalán y castellano, residente algunos años (ca. 1416- 1429) de manera intermitente en la corte valenciana de Alfonso V de Aragón y Juan de Navarra, influyó en el concepto de literatura del autor de la novela caballeresca Curial e Güelfa (Enyego d’Àvalos?), escrita en catalán (Nápoles-Milán, c. 1445-1448) y relacionable con la corte italiana del Magnánimo. El Curial presenta conexiones intertextuales con la obra de Villena, además de hápax y neologismos compartidos. Su autor conoció, sin duda, Los dotze treballs d’Hèrcules (Valencia, 1417) y parodió errores mitográficos de la Eneida romanceada, glosada y moralizada por Villena (Valencia, 1427-1429), dos obras a las que alude implícitamente en la suya. Ambos escritores difundieron el ideal del vir scientificus Hércules (Coluccio Salutati) como alegoría del esfuerzo que los caballeros sçientíficos/scientífichs ponían en estudiar los clásicos greco-latinos para crecer en virtud. Y ambos parece que anticiparon un «virgilianismo político» interpretable como la idea de embellecer literariamente los hechos históricos para eternizar la gloria militar en un digno formato.
Las paremias de la Crónica troyana promovida por Alfonso Onceno (1312-1350) en su contexto filológico: inestabilidad, ritmo y fijeza
Authors: Pla Colomer Francisco Pedro
Published: February 2021

La presente investigación consiste en el estudio de las paremias documentadas en la Crónica troyana promovida por Alfonso Onceno, inserta en la línea genética del Roman de Troie. El análisis filológico de la misma, complementado con descripciones interdisciplinares procedentes de ámbitos como la fonética o la morfología históricas contrastivas, servirá de complemento para enmarcar la obra en su contexto determinado, así como conducirá al examen variacional de los refranes en el marco de una fraseometría histórica.
El poema anónimo Castrianus (h. 1440-1470). Edición, texto y traducción
Authors: Alvar Nuño Guillermo
Published: February 2021

El presente artículo contiene la primera traducción al español de un poema inglés, el Castrianus, compuesto a mediados del s. XV. El poema tenía una intención didáctica y pretendía enseñar a los jóvenes ingleses internados en algún centro de enseñanza (laico o monacal) el correcto comportamiento en la mesa, pues el acto de la comida constituía un elemento fundamental para la articulación de la vida en sociedad tanto en el ámbito familiar como en el público. El Castrianus entronca en una tradición de textos didácticos que enseña modales y reglas morales que se agruparon en una colección conocida como Auctores octo. Sus antecedentes más directos son los Libri Catoniani, un suplemento que se le añadió en el siglo XII llamado Facetus: cum nihil utilius o, de forma más local, el Stans puer ad mensan domini de Robert de Grosseteste. Se pretende, pues, contextualizar el Castrianus, realizar un comentario métrico que explique qué tipo de verso se emplea y, por último, ofrecer tanto el texto latino como una traducción poética.
Sobre textos, traducciones medievales y otros demonios (reseña crítica de Dante vestido a la castellana: el Infierno de Pedro Fernández de Villegas de Roberto Mondola)
Authors: Lucía Megías José Manuel
Published: February 2021

Reseña del libro: Roberto Mondola, Dante vestido a la castellana: el Infierno de Pedro Fernández de Villegas, Madrid-Frankfurt am M.: Iberoamericana-Vervuert, 2017.
BNM ms. 19 (olim A 16): Mirabilia Orientalia. Introducción, edición y traducción
Authors: Ibáñez Chacón Álvaro
Published: February 2021

El ms. 19 de la BNM conserva una versión epitomada de la carta sobre los Mirabilia Orientalia, epístola pseudepígrafa de gran importancia para la tradición de las maravillas de Oriente durante el Medievo y el Renacimiento, conservada en dos redacciones diferentes y en varias versiones epitomadas. Aunque hay ediciones sinópticas de las principales versiones de ambas redacciones, el texto del ms. 19 de la BNM sigue inédito. En este trabajo editamos y traducimos por primera vez la versión Matritensis de la carta en confrontación con el resto de versiones de la misma redacción.
FEATURES OF TECHNOLOGICAL INFRASTRUCTURE FOR SUPPORT OF SOCIAL ENTREPRENEURSHIP ON THE EXAMPLE OF VOLGOGRAD REGION
Authors: Гончарова Елена Вячеславовна , Старовойтов Михаил Карпович
Published: February 2021

В статье авторы рассматривают способы поддержки социального предпринимательства. Приводится характеристика технологической инфраструктуры и ее ключевые особенности в современных экономических условиях развития. В практической плоскости этот вопрос представлен на примере инфраструктуры и способов поддержки в Волгоградской области.

In the article, the authors consider ways to support social entrepreneurship. Description of technological infrastructure and its key features in modern economic conditions of development is given. In practical terms, this issue is presented on the example of infrastructure and support methods in the Volgograd region.
USING PAIR AND GROUP WORK IN ENGLISH LESSONS IN GRADES 8-9
Authors: Шихмагомедова Эльнара Назимовна , Рабаданов Габибулла Муталипович
Published: February 2021

В статье рассматриваются теоретические основы использования технологии группового и парного обучения и практическое применение технологии на уроках английского языка в 8-9 классах.

The article discusses the theoretical foundations of using the technology of group and pair learning and the practical application of the technology in English lessons in grades 8-9.
RUSSIA AND INTERNATIONAL SOCIETY IN A NEW WORLD ORDER
Authors: Сардар Алаа
Published: February 2021

Статья посвящена важной научной проблеме - теоретическим моделям исследования современного международного порядка. Особое внимание уделено исследованию парадигмы мирового порядка. Определены уровни и формы зависимости международного порядка от характера международной системы, структурных характеристик системы, особенностей иерархии ее элементов и взаимосвязей между ними.

The article is devoted to the analysis of an important scientific issue -theoretical models of the modern international order. Special attention is being paid to the paradigm of the world order. In turn, it articulates the levels and forms of dependence of the international order in framework of international system, the structural characteristics of the system, the elements of hierarchical characteristics as well as their relations.
TOOLS AND FACTORS FOR THE DEVELOPMENT OF INNOVATION PROCESSES IN THE REGIONAL INNOVATION SYSTEM
Authors: Бугакова Мария Сергеевна
Published: February 2021

Целью исследования является изучение инструментов и факторов развития инновационных процессов в региональной инновационной системе. В процессе проведения исследования были использованы следующие методы: индукция, аналитический метод, наблюдение. В результате проведенного исследования были выявлены инструменты и факторы развития инновационных процессов в региональной инновационной системе.

The purpose of the research is to study the tools and factors of development of innovation processes in the regional innovation system. During the research, the following methods were used: induction, analytical method, observation. As a result of the research, tools and factors for the development of innovation processes in the regional innovation system were identified.
IMPROVING STAFF DISCIPLINE
Authors: Андреева Наталия Наильевна , Алексеев Владислав Геннадьевич
Published: February 2021

В данной статье рассмотрим наиболее важные аспекты определения трудовой дисциплины персонала, рассмотрим обязанности как работника, так и работодателя, выявим основные нарушения и предложим улучшения трудовой дисциплины.

In this article, we will consider the most important aspects of determining the labor discipline of personnel, consider the responsibilities of both the employee and the employer, identify the main violations and suggest improvements to labor discipline.
Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups
Authors: Rafieiolhosseini Neda , Killa Matthias , Tötsch Niklas , Grad Jean-Noël , Höing Alexander , Ottmann Christian , Knauer Shirley K , Voskuhl Jens , Hoffmann Daniel
Published: February 2021

The 14-3-3 protein family, one of the first discovered phosphoserine/phosphothreonine binding proteins, has attracted interest not only because of its important role in the cell regulatory processes but also due to its enormous number of interactions with other proteins. Here, we use a computational approach to find the binding sites of the designed hybrid compound featuring aggregation-induced emission luminophores as a potential supramolecular ligand for 14-3-3z in the presence and absence of C-Raf peptides. Our results suggest that the area above and below the central pore of the dimeric 14-3-3z protein is the most probable binding site for the ligand. Moreover, we predict that the position of the ligand is sensitive to the presence of phosphorylated C-Raf peptides.
Concepciones de la discapacidad y nueva genética: un abordaje a partir de un dilema bioético
Authors: Gastaldi Paula
Published: February 2021

A través de un proceso de fecundación asistida, una pareja de mujeres con sordera ha decidido implantar a la persona gestante un embrión genéticamente predispuesto a desarrollar sordera, seleccionando un donante de esperma que garantice dicha condición por sucesivas generaciones de sordera en su familia.  Analizaremos dicho caso como un dilema toda vez que entran en choque dos principios bioéticos: el principio de autonomía de la paciente, por un lado; el principio de no maleficencia, por el otro. El objetivo de este artículo es interrogar acerca de las diversas concepciones de la discapacidad y cómo estás impactan en el modelo de trato brindado a personas con discapacidad. Siendo que no existe unanimidad acerca de cómo debemos conceptualizar la discapacidad y qué implicancias tiene cada modo de conceptualizar a la hora de asumir discusiones filosófico-políticas, abordaremos las distintas concepciones sobre la discapacidad a los efectos mostrar cómo cada concepción razonaría, justificaría y resolvería el dilema moral vinculado a la selección genética.

 

Through a process of assisted fertilization, a couple has decided to implant in the pregnant person an embryo genetically predisposed to develop deafness, selecting a sperm donor that guarantees this condition for successive generations of deafness in their family. We will analyze this case as a dilemma whenever two bioethical principles come into shock: the principle of patient autonomy, on the one hand; the principle of non-maleficence, on the other. The objective of this article is to question about the different conceptions of disability and how they impact the model of treatment offered to people with disabilities. Since there is no unanimity about how we should conceptualize disability and what implications each way of conceptualizing has when assuming philosophical-political discussions, we will approach the different conceptions of disability in order to show how each conception would reason, justify and solve the problem. moral dilemma linked to genetic selection.
Transporte marítimo y transporte aéreo internacionales en el contexto de la pandemia de la Covid-19
Authors: Ford Ferrer Guillermo C.
Published: February 2021

Tanto en el ámbito del transporte marítimo, como en el del transporte aéreo, los organismos internacionales de derecho público y de derecho privado han hecho honor a la característica de dinamismo evolutivo de sus respectivos regímenes jurídicos, reaccionando muy rápidamente al contexto de la pandemia del Covic-19. Es así como producidos los primeros informes de la OMS, dichas entidades comenzaron a dictar un conjunto de resoluciones y disposiciones tendientes a preservar la seguridad sanitaria de los transportes involucrados, con la particularidad de que tales medidas no constituyan obstáculos absolutos para la conectividad y la comercialización de bienes considerados de consumo esencial. Al mismo tiempo se programa un retorno seguro a la normalidad y el pleno desarrollo de la libre circulación de personas y bienes.

 

Both in the field of maritime transport and air transport, international bodies governed by public and private law have honored the evolutionary dynamism of their respective legal regimes, reacting very quickly to the context of the Covic pandemic -19. Thus, when the first OMS reports were produced, these entities began to issue a set of resolutions and provisions aimed at preserving the health security of the transport involved, with the particularity that such measures do not constitute absolute obstacles to connectivity and commercialization. of goods considered essential consumption. At the same time, a safe return to normality and the full development of the free movement of people and goods are scheduled.