bluuebunny/crossref_metadata_2025 huggingface dataset:
A Questionnaire on Decolonization
Authors: Copeland Huey , Foster Hal , Joselit David , Lee Pamela M.
Published: December 2020

The term decolonize has gained a new life in recent art activism, as a radical challenge to the Eurocentrism of museums (in light of Native, Indigenous, and other epistemological perspectives) as well as in the museum's structural relation to violence (either in its ties to oligarchic trustees or to corporations engaged in the business of war or environmental depredation). In calling forth the mid-twentieth-century period of decolonization as its historical point of reference, the word's emphatic return is rhetorically powerful, and it corresponds to a parallel interest among scholars in a plural field of postcolonial or global modernisms. The exhortation to decolonize, however, is not uncontroversial-some believe it still carries a Eurocentric bias. Indeed, it has been proposed that, for the West, de-imperialization is perhaps even more urgent than decolonization.

What does the term decolonize mean to you in your work in activism, criticism, art, and/or scholarship? Why has it come to play such an urgent role in the neoliberal West? How can we link it historically with the political history of decolonization, and how does it work to translate postcolonial theory into a critique of the neocolonial contemporary art world?

Respondents include Nana Adusei-Poku, Brook Andrew, Sampada Aranke, Ian Bethell-Bennett, Kader Attia, Andrea Carlson, Elise Y. Chagas, ISUMA, Iftikhar Dadi, Janet Dees, Nitasha Dhillon, Hannah Feldman, Josh T. Franco, David Garneau, Renee Green, Iman Issa, Arnold J. Kemp, Thomas Lax, Nancy Luxon, Nelson Maldonado-Torres, Saloni Mathur, Tiona Nekkia McClodden, Alan Michelson, Partha Mitter, Isabela Muci Barradas, Steven Nelson, Ugochukwu-Smooth C. Nzewi, Alessandro Petti, Paulina Pineda, Christopher Pinney, Elizabeth Povinelli, Ryan Rice, Andrew Ross, Paul Chaat Smith, Nancy Spector, Francoise Verges, Rocio Zambrana, and Joseph R. Zordan.
Misfit micrelytrines: revised identities for two extinct true bugs (Heteroptera)

Authors: SWANSON DANIEL R.
Published: December 2020

It is no secret that fossilization can be a fickle process, being strongly influenced by a number of abiotic (e.g., habitat, oxygen level, isolation from other organisms, deposition, land disturbance, type of fossilization) and biotic (e.g., skeletal type, size of organism, life stage, population size) factors (e.g., Zherikhin, 2002). It also is a tremendously slow process, providing an extensive window of time for those forces to exert their influence. The result is a highly variable state of preservation from fossil to fossil. Some are extraordinarily true-to-life depictions of what the organism actually looked like millions of years ago (Li et al., 2013; Swanson et al., in press). Others, disarticulated and/or subject to geological pressures and upheavals, can fossilize less completely, with the resulting “depiction” difficult to interpret. More than occasionally, low preservational quality negatively affects taxonomic resolution, resulting in the misidentification or erroneous placement of fossil taxa (e.g., Popov, 2007; Fikáček & Schmied, 2013).
SEARCH FOR POTENTIAL LIGANDS FOR TRPM8 WITH THE HELP OF COMPUTER DESIGN
Authors: Borodin Evgeniy
Published: December 2020

A search was carried out for potential ligands to TRPM8 - a representative of the family of cationic channels with a transient receptor potential involved in the development of bronchial hypersensitivity and the occurrence of bronchospasm in response to low temperatures. We used a structural design and molecular docking using the autodock software package (http://autodock.scripps.edu/), which allows automated testing of many potential ligands for TRPM8. Docking was carried out with tyrosine 745 (Y745) amino acid residue as a critical residue for channel sensitivity to menthol, a classic TRPM8 agonist. The selection of potential candidates for the role of drugs intended for the treatment of bronchial cold hyperreactivity using in silico methods can be supplemented by testing their biological activity in vitro experiments with cell and tissue cultures and in vivo with experimental animals.
EQUIVALENCE OF TWO DEFINITIONS OF JOINT ACTION OF k BINARY FACTORS NOTION
Authors: Nagrebeckaya Yuliya , Panov Vladimir
Published: December 2020

In the formal model of the binary sufficient cause theory two definitions of a notion “joint action of k factors in a given outcome” are known. One of them appeals to a logical structure of the outcome, and another uses some formal notions of Boolean algebras theory. We discuss peculiarities of either definition and formulate their equivalence statement.
A NEW APPROACH TO THE CONSTRUCTION OF A HUMAN AGING SCHEME
Authors: Kaurov B
Published: December 2020

A new approach to the construction of a diagram of human aging is presented, based on the shift of emphasis from the visual display of a graph to its computer analysis. The disadvantages of the old approach and the advantages of the new one are shown. On the basis of the new approach, the graphical system “AgeMap” was created and the statistical analysis of the graph of human aging, consisting of 2200 nodes, was carried out. The prospect of further application of this system is shown.
SEMANTIC REPRESENTATION OF THE DISEASE KNOWLEDGE FOR A DECISION SUPPORT SERVICE IN CARDIOLOGY
Authors: Petryaeva Margarita
Published: December 2020

An information resource for a diagnostic Internet service in the field of cardiology has been formed - a declarative knowledge base of diseases of the cardiovascular system. The knowledge base includes formal descriptions of heart diseases, with possible causes, necessary conditions, risk factors, symptoms and syndromes, and a description of the dynamics of clinical manifestations. Representation of knowledge in the form of a semantic network ensures their development in the process of service operation.
MODELING OF INFORMATION PROCESSES OF INFORMATION-ANALYTICAL SYSTEMS OF EPIDEMIOLOGICAL MONITORING
Authors: Semichevskaya Natal'ya
Published: December 2020

The work identified, reviewed and structured information processes in the model of the information and analytical system of epidemiological monitoring. A generalized structural model of the system and information and analytical technologies that implement the functioning of the epidemiological monitoring system are proposed
COMPARATIVE ASSESSMENT OF AIRWAY CELLULAR INFLAMMATION IN PATIENTS WITH BRONCHIAL ASTHMA IN RESPONSE TO HYPOSMOLAR AND COLD STIMULES
Authors: Pirogov Aleksey , Prikhodko Anna , Afanas'eva Evgeniya , Perelman Yuliy
Published: December 2020

An approach is presented to the study of cellular inflammation using cytological analysis of sputum in patients with bronchial asthma with different types of airway reaction to bronchoprovocation with cold air and distilled water. When the airways are hyperresponsive to hypoosmolar and cold stimuli, it has been established the activation of the neutrophilic component of bronchial granulocytes. Cold airway hyperresponsiveness is associated with an increase in neutrophil content and a concomitant decrease in the number of macrophages in the inflammatory pattern of the bronchi. An increase in sputum cytosis is inherent in a positive airway response to a hypoosmolar test with an unexpressed dynamics of the level of bronchial eosinophils.
ANALYSIS OF THE GROWING PROCESS OF SOY BEAN
Authors: Statsenko Ekaterina
Published: December 2020

Prediction of technological processes in various sectors of the food industry using mathematical modeling is becoming increasingly important. The paper describes the effect of various factors on the grain weight after germination by the method of correlation-regression analysis. Using this modeling method, based on the established relationship, it is possible to predict the weight of the grain after germination in various conditions.
The reciprocal relation between morphological awareness and spelling in Chinese: A longitudinal study of primary school students
Authors: Li Liping , Li Ruiying , Wu Xinchun
Published: December 2020

Spelling is a literacy skill that must be mastered during children’s academic development. It involves a variety of cognitive factors, including morphological awareness. Studies in the alphabet and Chinese systems have shown that there is a close relationship between morphological awareness and spelling. Although there is clearly a significant unidirectional effect of morphological awareness on spelling significantly, few studies have explored the bidirectional relationship between morphological awareness and spelling. This three-time point longitudinal study was designed to investigate the reciprocal effects of morphological awareness and character spelling in Chinese. Participants included 124 children from two primary schools in Mainland China. The students were tracked from first grade to third grade and were administered a battery of tests to measure morphological awareness (e.g., homophone awareness, homograph awareness, and compounding awareness) and spelling to dictation, controlling for IQ, phonological awareness, and orthographic awareness. A structural equation model was utilized to examine the reciprocal relation between the students’ morphological awareness and character spelling. Results showed that earlier morphological awareness predicted subsequent spelling abilities from first grade to third grade and spelling in first grade predicted morphological awareness in second grade; however, spelling in second grade did not predict the subsequent morphological awareness in third grade. This study suggests that there is a bidirectional association between morphological awareness and spelling from first grade to second grade in Chinese, and a unidirectional association between morphological awareness and spelling from second grade to third grade. Future studies could examine the causal relationship between morphological awareness and character spelling by using an instructional intervention.
El cine de poesía: ¿una «referencia literaria innecesaria»?
Authors: Mirizio Annalisa
Published: December 2020

¿Necesita el cine pensarse a sí mismo a través de la poesía? ¿Son las referencias literarias necesarias al pensamiento cinematográfico? Estas son algunas de las cuestiones que surgieron cuando, en 1965, Pier Paolo Pasolini recurrió a la poesía para definir la nueva tradición visual-narrativa que veía afirmarse en el cine. Este trabajo retoma algunos puntos de la que fue una de las propuestas teóricas más audaces del cineasta italiano y sugiere leer el «cine de poesía» como movimiento entre dos paradigmas críticos, el literario y el fílmico, gesto que sitúa su propuesta más allá del debate promovido por la semiología. La referencia literaria se vuelve así necesaria, no para retornar al simbolismo poético, ni al cine poético y menos aún al cine como poesía visual, sino para pensar el cine como sistema o modo de representación, como defenderá Noël Burch poco después.
Noches blancas: un discurso poético
Authors: Russo Serena
Published: December 2020

ste trabajo analiza la relación entre poesía y cine, investigando dentro de la más amplia tradición de relaciones entre palabra e imagen y, más concretamente, en el concepto de adaptación. De hecho, en la trasposición de una novela a la pantalla el cine se ha centrado casi siempre en los aspectos narrativos. Sin embargo, en este artículo queremos demostrar la existencia de un cine que destaca por no conectar directamente con la narratividad, sino con un diferente nivel artístico menos convencional. Partimos, pues, de un cine que llamamos poético, no necesariamente enlazado con la época de las vanguardias, sino que ha de buscarse también en la obra de algunos directores del cine moderno. Nos centraremos en la obra del director italiano Luchino Visconti, y, en concreto, en la película Noches blancas, que manifiesta en su estructura y en su forma un lenguaje diferente que podemos calificar como poético. A lo largo de las siguientes páginas iremos definiendo el concepto de poeticidad a partir del análisis de esta obra fílmica.
GLIOBLASTOMA MULTIFORME: THE UNIQUE AND FATAL BRAIN TUMOR
Authors: Nandi Amartya , Srivastava Sanjeeva
Published: December 2020

Glioblastomas are the most aggressive and most founded type of common type of CNS cancer which are mainly classified into 2 major groups i.e. low grade gliomas (LGG) and high grade gliomas (HGG) and exhibits both intra and inter tumor heterogeny

LGG are showing low proliferation rate and further divided two sub types that are Grade I and Grade II which are commonly infiltrative and recur and they occur usually due to mutations in IDH-1 and IDH-2 genes.

Whereas, HGG are further divided two sub types Grade III and Grade IV showing nuclear atypia and most aggressive necrosis and high angiogenesis rate.
Élelmiszertörténet: az 1900-1950-es évek
Authors: Polgár Annamária , Mák Erzsébet
Published: December 2020

For centuries, men were self-reliant and consumed typically the food produced on one’s own territory. With advancing Industrial Revolution, development started also in the agriculture and food production set on a large scale, with cheap mass products and companies could serve larger populations. Metropolitan life has adapted to cater to the growing crowds, with smaller stores slowly becoming supermarkets where everything could be found in the same place. Innovation efforts have also brought about the freezer, vacuum packaging or microwave, all of which made available to the public. Foods changed to be enriched with vitamins and minerals for a better nutrient supply, and packaging techniques followed this evolution. This study aims to look over the history of alimentation and the change of food production from the 1900s to the 1950s324including both World Wars respectively.
Налоговое право
Authors: Козырин Александр Николаевич
Published: December 2020

Учебник содержит базовый объем академических знаний по налоговому праву. В нем рассмотрены основные понятия, источники, принципы и субъекты налогового права; в доступной форме изложено учение о налогах. Представлена система налогов, сборов и страховых взносов, а также действующих в Российской Федерации специальных налоговых режимов. Проанализированы ключевые институты современного российского налогового права: элементы юридического состава налога, налоговая обязанность и ее исполнение, налоговый контроль и ответственность за нарушение законодательства о налогах и сборах. Особое внимание уделено вопросам защиты прав и законных интересов налогоплательщиков. Учебник предназначен для студентов бакалавриата факультета права НИУ ВШЭ и юридических вузов, а также слушателей системы повышения квалификации.
Estimation Technique for a Contact Point Between two Materials in a Stationary Heat Transfer Problem
Authors: Umbricht Guillermo Federico , Rubio Diana , Tarzia Domingo Alberto
Published: December 2020

An inverse problem for a stationary heat transfer process is studied for a totally isolated bar on its lateral surface, of negligible diameter, made up of two consecutive sections of different, isotropic and homogeneous materials. At the left boundary, a Dirichlet type condition is imposed that represents a constant temperature source while a Robin type condition that models the heat dissipation by convection is considered at the right one. Many articles in the literature focus on thermal and stress analysis at the interface but no one is dedicated to the estimation of the contact point location between the two materials. In this work, it is assumed that the interface position is unknown. A technique to determine it from a unique noisy flow measurement at the right boundary is introduced. Necessary and sufficient conditions are derived in order to obtain the estimation of the interface point from a heat flux measured at the right boundary. Numerical solutions are obtained together with an expression for the estimation error. Moreover, an elasticity analysis is included to study the influence of data errors. The results show that our approach is useful for determining the location of the materials interface.
A New Technique to Solve Two-Dimensional Viscous Fluid Flow Among Slowly Expand or Contract Walls
Authors: Al-Saif Abdul-Sattar J. , Al-Griffi Takia Ahmed J.
Published: December 2020

In this research, we have proposed a new technique to solve two-dimensional (2D) viscous fluid flow among slowly expanding or contracting walls. The new technique depends on combining the algorithms of Yang transform and the homotopy perturbation methods. The results, obtained from the first iteration and by using the new method, show the accuracy and efficiency of this method compared to the other methods, used to find the analytical approximate solution for the problem caused by the 2D viscous fluid flow. Moreover, the graphs of the new solutions show the validity, usefulness and necessity of the new method.
Cultivando com mãos especiais
Authors: De Assis Pereira Bruna , Goede de Souza Alexandra , Münch Daniela , Bara Orlando , De Oliveira Neves Leonardo , Looz Gutz Marisete
Published: December 2020

O objetivo deste trabalho é relatar a experiência dos estudantes do Programa de Educação Tutorial (PET) Agroecologia Rural Sustentável, do Instituto Federal Catarinense (IFC) – Campus Rio do Sul, com os alunos da Associação de Pais e Amigos dos Excepcionais (APAE). Tal intento foi concretizado a partir da implantação de uma horta, utilizando princípios agroecológicos no manejo do solo e das plantas, focando na alimentação saudável e na preservação do meio ambiente. O projeto teve início em 2015, nas dependências da APAE do município de Rio do Sul/ SC, com duração de cinco anos (2015 a 2019). Os encontros foram realizados duas vezes por semana, com duas horas cada, e participação média de 15 alunos de várias faixas etárias e diferentes deficiências psicomotoras. Durante a realização do projeto foram desenvolvidas diversas atividades como, por exemplo, construção da horta, produção de mudas, plantio e manejo de plantas, além da colheita e consumo dos alimentos produzidos pelos alunos do projeto. No decorrer das atividades, ficou evidente o efeito benéfico do projeto no desenvolvimento e crescimento das pessoas envolvidas, não somente dos alunos da APAE, mas de todos os estudantes e profissionais participantes. Além disso, o projeto permitiu a experimentação da extensão pelos estudantes e a inserção do IFC – Campus Rio do Sul na sociedade como protagonistas do desenvolvimento e da inclusão social, corroborando a essência do projeto de extensão.
Exploration of differential methylation-driven genes to identify key epigenetic genes for prognosis of ovarian serous cystadenocarcinoma
Authors: Jiang Xingyu , Qiu Jiaqi , Chen Jueming , Li Han , Zhang Yanna
Published: December 2020

Background: Ovarian cancer is the leading cause of gynecological cancer-related mortality. The majority of patients have poor prognosis due to the lack of available biomarkers capable of predicting prognosis accurately and providing novel targeted therapy options.Methods: The methylation array data, gene expression profile and clinical information of 351 ovarian serous cystadenocarcinoma (OSC) samples as well as the methylation array data of another 10 normal ovarian epithelial tissues were accessed from The Cancer Genome Atlas (TCGA) and served as training dataset. An algorithm, MethylMix, was on the basis of a β mixture model to compare the DNA methylation status in tumor to normal DNA methylation status and then screened out hypo and hypermethylated genes of OSC, which were transcriptionally predictive. Gene Ontology (GO) enrichment and ConsensusPathDB pathway analysis of differential methylation-driven genes were further performed. A linear risk model was constructed through the univariate and multivariate COX regression with Akaike Information Criterion (AIC). Datasets of OSC from Gene Expression Omnibus (GEO) database were served as validation datasets to determine the prognostic value of the risk model. The Kaplan-Meier analysis was then used to evaluate the ability of the risk model to distinguish the survival in training dataset or validation dataset, even in subgroups of patients with different FIGO stage, histologic grade, residual tumor after surgery, and anatomic neoplasm subdivision. The receiver operating characteristic (ROC) curve was also applied to determine the value of risk model on predicting the prognostic survival of patients as well as compared with other 15 known prognostic biomarkers in OSC.Results: Totally 171 differential methylation-driven genes were identified between OSC and normal samples. Five of them, UBB, PLAT, TMOD1, KCNJ11, and CDSN, were selected to construct the prognostic risk model. The Kaplan-Meier analysis demonstrated that the survival rate in low-risk cohort was significantly higher than that in high-risk cohort in both training dataset and validation dataset (P<0.0001 for training dataset; P<0.05 for validation dataset). Further, the ROC analysis confirmed the prognosis-predict value of the risk model applicable not only in different group of patients but also more accurately when compared with other biomarkers.Conclusions: Our study successfully identified multiple methylation-driven genes in OSC and constructed a novel prognostic risk model to provide bioinformatic basis and an important tool for guiding subsequent OSC early diagnosis, prognosis assessment, and clinical treatment.
The Relationship Between Recommended and None Recommended Food Scores on Cardiovascular Risk Factors in Obese and Overweight Adult Women: A Cross Sectional Study
Authors: Sabbari Maryam , Mirzababaei Atieh , Shiraseb Farideh , Mirzaei Khadijeh
Published: December 2020

Objective: No studies have examined the relationship between recommended food score (RFS), none recommended food score (NRFS) and cardiovascular risk factors. This study was conducted to evaluate the association of RFS and NRFS with cardiovascular risk factors in overweight and obese women.Methods: This cross-sectional study was performed on 379 overweight and obese (BMI ≥25 kg/m2) women aged 18-48 years. Anthropometric measurements and body composition analysis were assessed in all participants. Dietary intake was assessed by a valid and reliable food frequency questionnaire (FFQ) containing 147 items and RFS and NRFS calculated. Biochemical assessments including TC, HDL, LDL, TG, FBS, insulin, HOMA-IR and hs-CRP were quantified by ELISA.Results: The mean age and BMI of participants were 36.73±9.21 (y) and 31.17±4.22 (kg/m²) respectively. Binary logistic analysis showed that participants in the highest quartile of the RFS compared to the lowest quartile had 82% lower risk for Hypertriglyceridemia [OR=0.18, 95%CI=0.06-0.53, P=0.002] and 91% lower risk for abdominal obesity [OR=0.09, 95%CI=0.008-1.04, P=0.05]. in addition, Participants who were in the highest quartile of the RFS compared to the lowest quartile had lower HOMA-IR [OR=0.29, 95%CI=0.08-1.00, P=0.05]. subjects with high adherence to the NRFS had lower HDL [OR=2.11, 95%CI=1.08-4.12, P=0.02] and higher risk for Hypertriglyceridemia [OR=2.95, 95%CI=1.47-5.94, P=0.002] compared to low adherence. Conclusions: There was an inverse significant association between adherence to RFS and risk of Hypertriglyceridemia, insulin resistance, and abdominal obesity. There was a significant association between NRFS and Hypertriglyceridemia, and also we found an inverse relationship between NRFS and HDL.
WITHDRAWN: Developing an Electronic Search Strategy Algorithm for Detecting Professional Interpreter Use among Patients with Limited English Proficiency: A Derivation and Validation Study
Authors: Soleimani Jalal , Marquez Alberto , Weister Timothy , Barwise Amelia
Published: December 2020

Background
Evidence exists that disparities occur for patients with Limited English Proficiency (LEP) that impact the quality of medical services, outcomes, and patient satisfaction. Using interpreter services can reduce these negative impacts; therefore optimizing our understanding of interpreter use during patient care is important. Manual chart review is time-consuming. The objective of this study was to develop and validate a search strategy algorithm to detect patients who used professional interpreter services during their hospitalization.
Methods
We identified all adults who were admitted to the hospital who had at least one Intensive Care Units (ICU) admission during the hospital stay across the Mayo Clinic Enterprise between January 1, 2015, and June 30, 2020. Three random subsets of 100 patients were extracted from 60,268 patients admitted to an ICU to develop the search strategy algorithm. A physician reviewer conducted the gold standard manual chart review and these results were compared with the search strategy algorithm each time it was refined. Iterative modification of the search strategy was performed and sensitivity and specificity were calculated by comparing the results to the reference standard for both derivation cohorts and the final validation cohort. Any uncertainties were resolved by a second physician researcher.
Results
The first search strategy resulted in a specificity of 95.7% and a sensitivity of 93.5%. The second revised search strategy achieved a specificity of 96.7% and a sensitivity of 92.3%. The final version of the search strategy was applied to the validation subset and specificity and sensitivity were 92.6% and 100% respectively.
Conclusion
We successfully derived and validated a search strategy algorithm to assess interpreter use among hospitalized patients. Developing a search strategy algorithm with a high sensitivity can reduce the time required to abstract data from the medical record compared to manual chart review. This can be used to examine and understand patient needs for research and quality improvement initiatives.
Neoantigen Load as a Prognostic and Predictive Marker for Stage II/III Non-Small Cell Lung Cancer in Chinese Patients
Authors: Li Hui , He Ronghui , Xu Yanjun , Luo Taobo , Jin Kaixiu , Yuan Wuzhou , Zheng Zengguang , Liu Lanxuan , Liang Zebin , Li Ao , Zheng Zhiguo , Fan Yun
Published: December 2020

BackgroundPrognosis of stage II/III non–small-cell lung cancer (NSCLC) is unsatisfactory even after complete tumor resection and adjuvant chemotherapy. Tumors with high immunogenicity were defined as “hot tumors” and associated with clinical benefits from immunotherapy. Here we assessed the prognostic and predictive value of immunogenomic signatures and gene mutation characters for stage II/III non-small cell lung cancer in Chinese patients. MethodsNinety-one paired resected stage II/III NSCLC and normal tissues and peripheral blood samples, including 47 squamous cell lung carcinomas (SCC) and 44 lung adenocarcinomas (ADC), were collected and analyzed using the whole exome sequencing (WES) to identify gene mutation and immunogenomic signatures for association with clinicopathological variables and disease-free survival (DFS). ResultsA high number of tumor mutation burden (TMB, > 4 mutations/Mb) was associated with better DFS of NSCLC patients, although there was no such an association in SCC and ADC subgroups. Moreover, higher neoantigen load (NAL, > 2 neoantigens/Mb) exhibited better DFS and survival benefit after adjuvant chemotherapy in a low NAL subgroup of SCC patients but not in ADC subgroup. A high DNA damage repair (DDR) index (gene mutations occurred in at least three different DNA repair pathways) was associated with high NAL numbers and favorable DFS of SCC, but not in ADC patients. However, mutations of individual gene, oncogene pathways, and antigen presentation machinery genes, and human leukocyte antigen (HLA)-I number and HLA-I loss of heterozygosity (LOH) had no prognostic or predictive value for DFS of SCC or ADC patients. ConclusionGiven the present information, NAL was a useful biomarker for lung SCC prognosis and prediction of chemotherapy responses in Chinese patients. Further study with a larger sample size from multiple institutions is needed to confirm these data.
LRIG1 Modulated Radioresistance of Glioma via Regulating CTLA-4/AKT Signaling Pathway
Authors: Cheng Shiqi , Huang Xiangqun , Yuan Raorao , Zhang Yan
Published: December 2020

Background: Radioresistance has a great impact on prognosis of glioma patients. However, the potential mechanism underlying the radioresistance of glioma cells remains largely unknown. Methods: LRIG1 overexpression model was firstly established by using Flag-LRIG1 plasmid. The expression of LRIG1, CTLA-4 proteins were detected by western blot and IHC in cells and human tissue. Real-time PCR was used for deterring mRNA expression. Cell viability and apoptosis were detected using CCK-8 and Annexin-V/propidium iodide (PI), respectively. Co-Immunoprecipitation was used for detecting the combination of LRIG1 and CTLA-4 proteins. Results: LRIG1 was significantly down-regulated in radioresistant glioma cells. Overexpressed LRIG1 could promote the radiosensitivity of glioma cells, meanwhile, inhibit the expression of p-AKT and CTLA-4 protein in radioresistant glioma cells. Furthermore, LRIG1 combined with CTLA-4 and promoted CTLA-4 degradation. In human glioma tissue, LRIG1 was down-regulated, while CTLA-4 was highly expressed in glioma tissue. Finally, correlation analysis showed that the expression of LRIG1 was negatively correlated with expression of CTLA-4 and radioresistance of glioma patients. Conclusion: Our findings demonstrated that LRIG1 facilitates radioresistance glioma cells by regulating CTLA4 /AKT signaling pathway.
Enterprise risk-based management disclosures and firm value of Indonesian finance companies
Authors: Savitri Enni , Ary Gumanti Tatang , Yulinda Nelly
Published: December 2020

Rapid changes in business transactions and technology development have made risk-based management a significant issue for business entities. The ability in managing risk would lead to a better firm value. This study investigates the effect of enterprise risk-based management disclosures (ERMD) and intellectual capital (IC) on firm value. It also tests the moderating effect of profitability on the relationship ERMD and IC with firm value. It examines the annual reports of 49 finance firms listed on the Indonesia Stock Exchange (IDX). The data cover three years, from 2016 to 2018. It employs panel data regression to test the hypotheses. The results show that the effect of ERMD and IC on firm value is partially and positively moderated by profitability. The findings show that the application of ERDM and IC can increase firm value. The originality of this study is that profitability can moderate the effect of ERMD and IC on firm value. The increase of ERMD and IC management within the company must be balanced with profitability to raise capital from outside the company to increase firm value.
AcknowledgmentThe Research was conducted with the support of the Universitas Riau, Indonesia.
Short Term and Long term Building Electricity Consumption Prediction
Using Extreme Gradient Boosting
Authors: Tyagi Sakshi , Singh Pratima
Published: December 2020

Background:

Electricity is considered as the essential unit in today’s high-tech world.
The electricity demand has been increased very rapidly due to increased urbanization,(smart
buildings, and usage of smart devices to a large extent). Building a reliable and accurate electricity
consumption prediction model becomes necessary with the increase in demand for energy. From
recent studies, prediction models such as support vector regression (SVR), gradient boosting
decision tree (GBDT), artificial neural network (ANN), random forest (RF), and extreme gradient
boosting (XGBoost) have been compared for the prediction of electricity consumption and
XGBoost is found to be the most efficient method that leads to the motivation for the research.

Objective:

The objective of this research is to propose a model that performs future electricity
consumption prediction for different time horizons: short term prediction and long term prediction
using the extreme gradient boosting method and reduce prediction errors. Also, based on the
prediction of the electricity consumption, the best and worst predicted days are being recognized.

Methods:

The method used in this research is the extreme gradient boosting for future building
electricity consumption prediction. The extreme gradient boosting method performs predictions for
different time horizons(short term and long term) for different seasons(summer and winter). The
model was designed for a house building located in Paris.

Results:

The model has been trained and tested on the dataset and its prediction is accurate with
the low rate of errors compared to other machine learning techniques. The model predicts
accurately with RMSE of 140.45 and MAE of 28, which is the least value for errors when
compared to the baseline prediction models.

Conclusion:

A model that is robust to all the conditions should be built by enhancing the
prediction mechanism such that the model should be dependent on a few factors to make electricity
consumption prediction.
Исследование влияния поверхностного упрочнения на локальные механические свойства режущей кромки обрабатывающего инструмента
Authors: Кравчук К.С. , Красногоров И.В. , Русаков А.А. , Усейнов А.С.
Published: December 2020

В работе методом инструментального индентирования исследовались механические свойства режущей кромки вырубного штампа, модифицированной с помощью механического воздействия фрезерного инструмента и локального нагрева лазером. Построены профили твердости от глубины с помощью метода автоматизированного картографирования. Установлено, что обработка острия локальным нагревом с помощью лазера приводит к увеличению твердости сплава в 1,5 раза в области размером около 40 мкм.
Translations, Betrayals and Controversies in the Articulation of the Uncertainty Principle
Authors: Lima Nathan , Rosa Gabriela , Bento Miguel
Published: December 2020

In this paper, we discuss the potentialities and challenges of historical approaches related to the Symmetrical Anthropology proposed by Bruno Latour and collaborators. To accomplish this goal, first, we provide a brief account about how Sociology and Anthropology of Science evolved, stressing how these different movements correlate with historiographical approaches. Second, we introduce the metaphysical scheme of Symmetrical Anthropology and discuss which characteristics a historical narrative should have to be consistent with this world vision. Third, we briefly describe the articulation of the Uncertainty Principle focusing on appropriating such characteristics. Based on this concrete historical account, we discuss the potentialities and challenges of this approach to History of Physics.
PENINGKATAN KESADARAN AKAN PENGELOLAAN SAMPAH DI DESA CINTA MULYA MELALUI WORKSHOP INTEGRATIF DAN KREATIF
Authors: Darmawan Ivan
Published: December 2020

Desa Cinta Mulya terletak di Kawasan Pendidikan Jatinangor, Kabupaten Sumedang. Peningkatan jumlah penduduk yang signifikan di Kecamatan Jatinangor secara tidak langsung membawa dampak kepada lingkungan Desa Cinta Mulya. Salah satu permasalahan yang dihadapi di lingkungan Desa Cinta Mulya adalah pengelolaan sampah yang belum memadai. Tidak adanya Tempat Pembuangan Akhir serta pengetahuan masyarakat akan pengelolaan sampah yang minim, menyebabkan lingkungan menjadi kotor dan tercemar. Maka dari itu, perlu adanya kegiatan untuk meningkatkan kesadaran warga akan pengelolaan sampah dan kebersihan lingkungan. Metode yang digunakan pada kegiatan ini merupakan metode Participatory Rural Appraisal, kemudian ditunjang dengan kegiatan workshop selama dua hari yang ditujukan bagi warga Desa Cinta Mulya terkhusus kaum ibu, karang taruna dan anak-anak. Kegiatan ini juga melibatkan core group atau tokoh masyarakat yang diharapkan dapat menyebarluaskan pengetahuan yang telah didapat. Kegiatan dengan anak-anak dilakukan dengan menarik, melalui pembuatan kreasi tempat sampah serta pemaparan materi mengenai sampah organik dan non-organik. Hasil dari kegiatan ini didapatkan bahwa terdapat peningkatan pengetahuan dan kepedulian masyarakat mengenai pengelolaan sampah serta kebersihan lingkungan.
Analisis Wacana Kritis Model Teun A.Van Dijk pada Surat Kabar Online dengan Tajuk Kilas Balik Pembelajaran Jarak Jauh Akibat Pandemi Covid-19
Authors: Mukhlis Muhammad , Masjid Akbar Al , Widyaningrum Heny Kusuma , Komariah Kokom , Sumarlam Sumarlam
Published: December 2020

This study aimed to describe the Teun A Van Dijk's model text's dimensions in online news text discourse on Kompas.com Newspaper with the headline "Flashback to Distance Learning due to the Covid-19 Pandemic" on September 3, 2020. This study's data were speech and dialogue on the online media kompas.com, while the data source for the online newspaper kompas.com is in the form of news texts about distance learning flashbacks due to the Covid-19 pandemic. Data The data collection methods and techniques used the documentation method with the observation and note technique. In contrast, the data analysis method used the content analysis method with the Teun A Van Dijk model of critical discourse analysis approach. The results of this study indicate that the dimensions of Teun A Van Dijk's text consist of three parts, namely the superstructure, macro-structure, and microstructure measurements. The superstructure dimension is about coherence and schematic of text. The macrostructure dimension discusses thematic/topics, namely examining flashbacks or evaluating the implementation of the distance learning policy announced by the Indonesian Minister of Education and Culture. The measurements of the microstructure that found in background elements, details, intentions, presuppositions, sentence form (passive and active sentences), coherence (additive/addition coherence, causal coherence, and contrast coherence), pronouns (their pronouns and us), lexicon, graphics, and metaphors (figure of speech).
Experimental and numerical investigations for I-girders in bending and shear stiffened by closed trapezoidal stiffeners for use in steel bridges
Authors: Oppe Matthias , Feldmann Markus , Naumes Johannes , Degée Hervé , Maquoi René , Boissonnade Nicolas
Published: December 2020

The paper summarizes the investigations on shear resistance of I-girders longitudinally stiffened by closed trapezoidal stiffeners, performed in the frame of a European RFCS project (RFS-CR-03018) designated as “ComBri” (Competitive Steel and Composite Bridges by improved Steel Plated Structures), with configurations typical of what may be expected in the design of modern steel bridges. It first reports on four full-scale tests performed at RWTH Aachen, on stiffened panels with strong closed stiffeners where the deformations have been measured with photogrammetric devices. As expected, failure in the subpanels has been governing. A devoted FEA shell model is then described and validated towards these results and other experimental sources. The numerical simulations demonstrate a very good agreement with the test-results. Parametric studies performed with a sophisticated numerical tool help pointing out several aspects where the recommendations of EN 1993-1-5 [1] on stiffened panels in bending and shear may be improved.
Experimental and Numerical Study of Full-range Behaviour of Partially
Prestressed Concrete Beams with External Tendons
Authors: Chan K. H. Enoch , Au Francis T. K. , Kwan Albert K. H.
Published: December 2020

One concern in the use of external prestressing in new construction and retrofitting of existing reinforced and prestressed concrete structures is the uncertainty of behaviour upon overloading up to failure. It is therefore necessary to study the full-range behaviour of such structures. This can be achieved by experimental investigation as well as numerical simulation. This paper reports the initial findings of experimental and numerical investigations of partially prestressed concrete beams with external tendons. A number of prestressed concrete beams with external tendons of either 7- wire steel strands or aramid fibre-reinforced polymer were tested to failure, so as to study the effect of prestressing on the ductility. The specimens tested all have T-sections having two external tendons with one on each side. The test specimens were analyzed by non-linear finite element method for comparison. The results from the numerical analyses agree well with the experiments. A parametric study was also conducted to evaluate the effects of initial prestressing force and tendon friction at deviators on their structural behaviour. The study provides insight into their fullrange behaviour and factors that should be considered in modelling such structures.
Durable and low-maintenance structural concrete infrastructures
are long-term societal assets
Authors: Edvardsen Carola , Rostam Steen
Published: December 2020

The societal assets and the complexity of designing well performing, low maintenance, and durable concrete structures are presented in this paper. The multidisciplinary set of problems to be solved by the designer in order to ensure a truly long service life with minimal maintenance is highlighted. The descriptions of the individual measures required to achieve this goal are shown to be relatively simple and based on well-known methods, materials, and technology, however. The key aspects, benefits, and pitfalls of these measures are outlined with particular emphasize on construction materials, structural detailing, and the quality of workmanship during construction. References to selected recent and current durability design and assessment projects are provided in an individual section.

The paper also illustrates the lack of integration of service life orientated design in available codes and standards and in the current design practice. Moreover, the different perspectives and demands of the owner or the client, the contractor, and the designer concerning durability design and the resulting discrepancies are reviewed and put into a societal context. Thereby, the need for a new design paradigm for concrete structures is formulated, exemplified, and sustained.
Condition Evaluation of Riveted Steel Bridges by Minimal Invasive Methods
Authors: Brandes Klaus
Published: December 2020

When searching for effective methods of investigating and rating existing bridges, the
different characteristics of bridges recommend a limitation of the subject: Concrete bridges
show other problems than steel or stone bridges.

For a specific large group of bridges, riveted steel bridges, figure 1, which were built during
the period of time from 1850 to 1950, a set of new methods has been developed and approved
which promise to improve considerably the diagnosis, rating and restoration of old steel
bridges.

Adapting the often used terminology of medicine, the termminimal invasive methodshas
been introduced comprising all the relevant methods and techniques. Up to now, the different
methods have been part of adjacent fields like non-destructive testing or material testing or
experimental structural analysis as well as fracture mechanics as a theoretical tool. However,
only all of them, in a concerted action, lead to a new quality of investigation and rating.
The different methods and their concerted application are presented and some examples of
successful application are given.
Modern expansion joints design, applications and developments
Authors: Flederer Holger , Stroetmann Richard
Published: December 2020

Expansion joints are a highly stressed component of bridge equipment. The modern expansion joints have developed into complicated constructions whose design criteria are determined by a wide requirement spectrum. The comprehensive definition of the requirement profile is derived from it. Various construction types are available as a function of the operating condition. At the moment a technical approvals guideline of expansion joints for road bridges originates within the scope of the efforts towards a harmonized European code of practice. In particular the load assumptions show differences for comparable valid national rules. Even more amplified efforts are undertaken to the advancement of the expansion joints in the fields of reduction noise emission and special operating properties - e.g., earthquake suitability.
Checking of Bridges for the new Taiwan High Speed Rail
Authors: Reinbeck Uwe
Published: December 2020

This paper deals with the independent checking of the design of bridges for the civil contracts C210 and C215 of the Taiwan High Speed Rail project. Both contracts covered a length of 51.4 km including a total length of 31.6 km of bridges (61.5%).
Planning of Rail Bridges on Katra Quazigund Railway line in Jammu & Kashmir
Authors: Mahajan Pradeep
Published: December 2020

Katra to Quazigund portion of 287 km long Udhampur-Srinagar-Baramulla rail New Rail Link Project (USBRL) in State of Jammu & Kashmir, India, covering 142 km stretch is located in rugged Himalayan Mountains. The alignment traverses geologically young Himalayas through active land slide zones and tectonically complicated geological conditions due to presence of Main Boundary Thrust. Main Boundary Thrust has been responsible for an earthquake of magnitude 7.6 on Richter scale in Oct 2005, with epicenter about 150 km away from site resulting in loss of more than 75000 lives. Owing to poor geological formations and difficult terrain, more than 73% of alignment passes through tunnels and further 10% portion of alignment on bridges or viaducts.

Planning & Design of bridges for rail alignment crossing deep valleys with steep unstable slopes is a daunting task. The curved rail alignment alongwith unstable, young geological formations, coupled with severe seismicity of area pose unique challenges while deciding upon the bridge configurations. The paper highlights various considerations in choosing bridge structural alternatives/configurations and materials for crossing such a difficult terrain.
Integrated Computer Wind Design for Bridge Engineering
Authors: Stampler Johann , Janjic Dorian , Domaingo Andreas
Published: December 2020

In the design process of long-span bridges the consideration of wind effects is a major point
because the extraordinary slenderness of these structures yields a considerable susceptibility for
wind-induced vibrations. Usually, extensive wind tunnel tests are performed to investigate the
aerodynamic behaviour of such structures. Due to increasing computer power, numerical CFD
methods are becoming a serious alternative at much lower costs. In the framework of the research
project NUWIMOD, a discrete vortex method was integrated into the structural analysis program
RM2006. This strong coupling of structural analysis and CFD calculation provides an opportunity
for fast and comprehensive investigation of wind effects. In this paper, aspects of the wind analysis
performed for the Hardanger fjord bridge project are presented.
Assessment of the bearing capacity of piles during static load test
Authors: Gavrilov Pavel , Glukhov Vyacheslav
Published: December 2020

The purpose of this research is to estimate the bearing capacity of bored piles with broadening, formed by stone rolling. A series of static tests of the existing piles was performed in accordance with the requirements of the current regulatory documentation, the analysis of the obtained results was carried out. According to this experimental researches, was made a conclusion about the advisable to take into account the standard values of settlements at the determining of the bearing capacity of piles by ground. The results of field tests were compared with the calculated values, determined by calculation with the recommendations of SP 24.13330.2011. Noted, that the value of load, corresponding to the moment of the pile «failure», should be taken as a criterion of the factual bearing capacity.
Dispepsia dan Pembahasannya
Authors: Kultsum Ummi
Published: December 2020

Dispepsia dapat dialami seseorang dikarenakan berbagai penyakit seperti gastritis, ulkus peptikum, penyakit celiac, pankreatitis, dan keganasan lambung. Dispepsia juga dapat terjadi karena pola hidup seseorang. Seperti perubahan pola makan yang tidak teratur, konsumsi obat-obatan yang tidak jelas, mengonsumsi yang mengandung zat-zat dalam nikotin dan alkohol, keadaan pikiran yang stress, sering mengonsumsi makanan pedas dan berlemak, dan makan terlalu banyak atau makan terlalu cepat.