bluuebunny/crossref_metadata_2025 huggingface dataset:
Süyûtî’nin Belâgat Anlayışı ve Belâgat İlmindeki Yeri
Authors: Çelik Ekrem
Published: October 2024

İslâmî ilimlere ait temel eserlerin ve özellikle İslâm’ın iki temel kaynağı olan Kur’ân’ın ve sünnetin anlaşılmasında belâgat ilminin özel bir yeri vardır. Bu önemine binaen birçok âlim belâgat ilmine ait eserler yazmışlardır. Bu âlimlerden birisi de Ebü’l-Fazl Celâlüddîn Abdurrahmân b. Ebî Bekr b. Muhammed el-Hudayrî es-Süyûtî eş-Şâfiî’dir (ö. 911/1505). Ancak Süyûtî’nin belâgat ilmine dair eserleri ve onun belâgat anlayışı konusunda yeterli araştırmalar yapılmamıştır. Literatür taraması neticesinde ulaştığımız birkaç araştırma da onun belâgate dair eserlerinin sayısı, tespiti gibi tali konulara yoğunlaşmış; Süyûtî’nin belâgat ilmindeki yeri, belâgat anlayışı gibi aslî konular yeterince ele alınmamıştır. Bu çalışma onun belâgat anlayışını, belâgat ilmindeki yerini ve eserlerinin belâgat alanı açısından önemini tespit etmek için yapılmıştır. Bu bağlamda Süyûtî’nin belâgatle ilgili eserleri incelenmiş, toplanan veriler analiz edilmiş ve elde edilen bulgular neticesinde onun belâgat ilmine önem verdiği, belâgati teorik olarak anlattığı Ukûdu’l-cümân gibi eserlerinde Mâverâünnehir merkezli Kelâmcılar Ekolü’ne uygun bir belâgat anlayışına; belâgat uygulamalarına ağırlık verdiği Cenâ’l-cinâs gibi eserlerinde de Irak- Şam- Mısır Edebiyatçılar Ekolü’nü yansıtan bir belâgat anlayışına sahip olduğu, onun bir belâgat kuramcısı olmaktan ziyade bir belâgat uygulayıcısı olduğu, belâgati amaç olarak değil araç olarak değerlendirdiği sonuçlarına ulaşılmıştır. Bu araştırma Süyûtî’nin belâgat ilmindeki yerini, onun belâgat anlayışını tespit açısından önem arz etmektedir.
Efficacy of using grape cane extracts against Plasmopara viticola under field conditions and their impact on the composition of berries and musts of Vitis vinifera L. cv. Riesling
Authors: Besrukow Paul , Will Frank , Berkelmann-Löhnertz Beate , Stoll Manfred , Schweiggert Ralf
Published: October 2024

Grapevine downy mildew caused by Plasmopara viticola is a deleterious vine disease currently controlled using synthetic and copper-based fungicides. Environmental concerns surrounding such fungicides necessitate sustainable alternatives like grape cane extracts. However, studies into their efficacy and effects on the product remain limited. This study aimed to assess the open-field efficacy of a novel grape cane extract formulation, alone and combined with a copper agent, against downy mildew, and to examine its impact on berry and must composition. The results were compared to standard fungicides frequently used in integrated and organic viticulture. In 2022, the grape cane extract formulation reduced downy mildew severity by 78 % on berry clusters, comparable to the maximum acceptable dose of copper for organic farming in Germany (3 kg/ha/a). Combining the grape cane extract with the copper agent was more effective than the copper agent alone, but not more effective than the grape cane extract alone. In 2023, disease development was marginal, despite artificial inoculation. Compositional differences detectable by FTIR were insignificant between musts derived from all treatments, increased copper levels were observed whenever copper had been applied. The phenolic content in freeze-dried, de-seeded berries of 2022 was significantly lower after copper (14.6 mg/g dry weight DW) and grape cane extract treatments (6.6 mg/g DW) when compared to the control (36.1 mg/g DW), with discrepancies in stilbenoid and flavan-3-ol levels in particular, as analysed by HPLC-DAD. However, these differences were not confirmed in 2023, with results showing no correlations between different treatments and phenolic contents. These findings suggest that applications of the phenolic grape cane extract do not lead to artificially altered levels or relevant residues of the active constituents; i.e., the phenolic compounds in the product. In brief, grape cane extracts might represent a promising natural alternative to controlling grapevine downy mildew, particularly in organic viticulture, which, to date, heavily relies on (eco-)toxic copper-pesticides. Further multi-year studies including wine analyses are warranted to follow the entire flow towards the final product.
Shortening the Payback Period of Greenhouse Gas Reduction Benefits from Photovoltaic Rooftop System
Authors: Rugthaicharoencheep Nattachote , Ruangsap Natchapol , Nedphokaew Supawud
Published: October 2024

This paper presents shortening the payback period of greenhouse gas reduction benefits from photovoltaic rooftop system. The objective was to evaluate the amount and returns of carbon credits. Economic analysis, and comparison of economic analysis with and without consideration of carbon credits from a 149.80 kWp, and 25.68 kWp photovoltaic rooftop system. This study evaluated the amount of electrical energy produced by a photovoltaic rooftop system estimated from the PVsyst program of the factory in Pathum Thani Province, Thailand. The economic indices that the researcher analyzed include the payback period, net present value (NPV), benefit cost ratio (B/C ratio), internal rate of return (IRR). It is divided into four cases studies: Case 1 is the base case, and Cases 2, 3, and 4 are considered carbon credits for 7, 14, and 25 years, respectively. The economic indices analyzed in Case 1 include financial internal rate of return (FIRR), payback period, financial net present value (FNPV), and B/C ratio. The economic indices analyzed in Cases 2, 3, and 4 are the economic internal rate of return (EIRR), economic net present value (ENPV), B/C ratio, payback periods, respectively. This paper outlines a new economic calculation approach that considers carbon credits produced by photovoltaic rooftop system to reach break-even points more quickly, and the application of carbon credits in conjunction with renewable energy.
Novel Approach to Conceptual Design of Enterprise Risk Management Software
Authors: Stanojevic Petar , Misita Mirjana , Đurić Goran , Kuzmanović Bogdan , Milošević Mladen , Balos Daniel
Published: October 2024

The problem is how to create a comprehensive "tool", applicable to any company, which will allow to achieve multiple effects at the same time, such as adhering to the ISO 31000 procedure, connecting risks and company goals in the manner defined by the COSO framework (by connecting the elements of the organizational structure with the company goals), assessment of all types of risks that a company may face, including technical, enable decision support and given visualization of data and effects. Solving this general problem requires solving many specific problems such as the creation of a specific risk matrixes for each company that will express its risk appetite but also to give the possibility of a comprehensive overview of all possible types of consequences, linking entities one-to-many and many-to-one in order to link the elements of the organizational structure to the goals that can be and common to several units, the acquisition of potential risks based on the knowledge of external experts, which overcomes the limitation of insight from the company and introduces elements of artificial intelligence, the application of standards for the evaluation of technical risks such as EN 16991 or API 580, 581 etc. while enabling the management of the implementation project and evergreening in the future. Our research question is can an integral model be made that will solve the above problems in an integrated way. The goal is to create software that will support this solution and that will be practically applicable. Solving such a complex problem of connecting various theoretical and practical aspects required creation of a special algorithm for connecting project activities, risks, organizational structure, goals, knowledge, data management and software. The algorithm, model and software were developed and successfully tested in two Serbian companies.
A Hybrid FMEA-ROC-COCOSO Approach for Improved Risk Assessment and Reduced Complexity in Failure Mode Prioritization
Authors: Anes Vitor , Abreu António
Published: October 2024

This paper proposes a novel hybrid model that integrates Failure Mode and Effects Analysis (FMEA), Rank Order Centroid (ROC) and COmbined COmpromise SOlution (COCOSO) to improve risk assessment and prioritization of failure modes. A case study in the healthcare sector will be conducted to validate the effectiveness of the proposed model. ROC is used to assign weights to the FMEA criteria (severity, occurrence and detectability). COCOSO is then applied to create a robust ranking of failure modes by considering multiple criteria simultaneously. The results of the case study show that the hybrid FMEA-ROC-COCOSO model improves the accuracy and objectivity of risk prioritization. It effectively identifies critical failure modes, outperforming traditional FMEA. The hybrid approach not only improves risk management decision making, leading to better mitigation strategies and higher system reliability, but also reduces the complexity typically found in FMEA hybrid models. This model provides a more comprehensive risk assessment tool suitable for application in different industries.
Universe Expanding vs Non-Expanding Interpretation of Friedmann Lemaître Robertson Walker (FLRW) Metric
Authors: Vicente Juan De
Published: October 2024

One of the keys to understanding the universe is the proper measurement of the relation between the luminosity distance dL and the angular diameter distance dA. In 1933, Etherington deduced from general relativity the reciprocity equation dL=dA(1+z)γ, with γ=1 for a local, i.e. non-expanding, universe. This equation was adapted to an expanding universe –through the comoving distance concept– with the value γ=2. On the other hand, the feasibility of an expanding universe rest on the Friedmann-Lemaître-Robertson-Walker (FLRW) metric that meets the Einstein’s Field Equations for an homogeneous and isotropic universe. The FLRW metric includes a time dependent factor a(t) – unlike the Einstein’s static universe– that accounts for the cosmological redshift. In this work, we show that the radial coordinate (r) of FLRW metric admits two different interpretations driving to an expanding and non-expanding universes. When r is considered has a radial comoving coordinate, the integration on r produces the comoving distance, and hence the metric drives to an expanding universe. Nevertheless, when r is considered simply has a radial coordinate, the integration on r produces the luminosity distance, and hence the metric drives to a non-expanding universe. Thus, weeding out the comoving concept, a non-expanding nature of FLRW model emerges, where a(t) accounts for the cosmological redshift in the form of a time downscaling or as a magnetic permeability growth with cosmic time, rather than as space scaling. Even more, the presence of the time varying factor a(t) drives to the same Friedmann equations, which guarantees the stability of the non-expanding universe, unlike the Einstein’s static universe.
Pengaruh Inventory Intensity dan Kepemilikan Manajerial Terhadap Agresivitas Pajak dengan Ukuran Perusahaan Sebagai Variabel Moderasi
Authors: Zainul Zaki , Prihatni Rida , Yusuf Muhammad
Published: October 2024

Penelitian ini bertujuan untuk mengetahui hasil dari pengaruh inventory intensity dan kepemilikan manajerial terhadap agresivitas pajak dengan ukuran perusahaan sebagai variabel moderasi. Penelitian ini menggunakan sumber data sekunder berupa laporan tahunan dan laporan keuangan perusahaan consumer non-cyclicals yang terdaftar pada Bursa Efek Indonesia (BEI) pada periode 2019-2022. Metode pengambilan sampel berupa purposive sampling dengan sampel sebanyak 36 perusahaan. Metode analisis data adalah analisis regresi data panel dan moderated regression analysis (MRA) dengan menggunakan EViews 13. Hasil yang diperoleh dalam penelitian ini antara lain: 1) Inventory intensity berpengaruh terhadap agresivitas pajak; 2) Kepemilikan manajerial tidak berpengaruh terhadap agresivitas pajak; 3) Ukuran perusahaan memoderasi pengaruh inventory intensity terhadap agresivitas pajak; dan 4) Ukuran perusahaan tidak mampu memoderasi pengaruh kepemilikan manajerial terhadap agresivitas pajak.
LATE MESOZOIC RARE-METAL GRANITES, PEGMATITES, AND GREISENS OF MONGOLIA: AGE, MINERALOGY, GEOCHEMISTRY, ORE POTENTIAL, AND PETROGENESIS
Authors: Antipin V.S. , Kushch L.V. , Odgerel D. , Sheptyakova N.V. , Khubanov V.B. , Belozerova O.Yu.
Published: October 2024

Comparative analysis of the earlier obtained and new geological data, age, mineral, petrological, and geochemical compositions of plutons of calc-alkalic granitoids and rare-metal Li–F granites shows their evolution in a wide time interval during the formation of Mesozoic areas of granitoid magmatism. Mineralogical and geochemical analysis of the evolution of plutons of palingenetic calc-alkalic granitoids (Baga Hentiyn (MZ1) and Ikh Narotiin = Hiid (MZ2)) and intrusions of rare-metal Li–F granites of Central and Eastern Mongolia revealed their petrological and geochemical differences. The closure of the Mongol–Okhotsk Basin with the formation of large plutons of calc-alkaliс granitoids, obviously related to collisional processes, did not cause significant enrichment of the late granite phases with lithophile and ore elements. Within the peripheral zones of еру MZ1 and MZ2 magmatic areas, mineralization is often associated with Mongolian multiphase plutons and small intrusions of rare-metal Li–F granites. The rare-metal granites are characterized by a decrease in indicative K/Rb, Nb/Ta, and Zr/Hf values and a regular increase in F, Li, Rb, Cs, Sn, W, Be, Ta, and Nb contents during the evolution of Li–F magmas. Igneous and, particularly, metasomatic rocks in most intrusions of ore-bearing rare-metal Li–F granites are characterized by significant variations in Sn and W contents. At the magmatic stage, the pegmatoid varieties of amazonite–albite granites and pegmatites of the zonal Baga Gazriin (MZ1) and Barun Tsogto (MZ2) plutons are significantly enriched in both Sn and W. Maximum Sn and W enrichment has been established in greisenized granites and zoned greisen bodies (zwitters), which is due to the percolation of ore-bearing solutions into the upper horizons and the mineralization of ore elements in the late phases of intrusions and in metasomatites. The wide variations in the age (321–126 Ma) and trace element and isotope compositions of Mongolian rare-metal Li–F granites within various zones of large magmatic areas suggest the influence of mantle plume sources on the composition of rare-metal granitic magmas and on their ore potential in intermediate chambers in the continental crust.
Estilos de crianza parental y ansiedad en escolares de 5to de secundaria de centros educativos estatales del distrito de Villa El Salvador
Authors:   , Reynoso Sheron Julissa Briggitte , Santos Rivas Annie Lisbeth
Published: October 2024

Esta investigación tiene como finalidad general establecer la correlación en las variables Estilo de Crianza Parental y Ansiedad en escolares de 5to de secundaria del distrito de Villa el Salvador. La metodología se caracteriza por ser de tipo básica, con enfoque cuantitativo, diseño no experimental, descriptivo correlacional y corte transversal. La muestra estaba compuesta por 358 escolares que cumplieron con los criterios de inclusión y exclusión. Las pruebas usadas para la medición de las variables fueron la Escala de Estilos de Crianza Parental y el Inventario de Ansiedad Rasgo- Estado (IDARE). Para analizar los datos se empleó el estadístico de coeficiente Rho de Spearman. Los resultados muestran valor de sig. 0.004 < 0.05 lo cual indica que existe correlación significativa entre el Estilos de Crianza Parental y la Ansiedad Estado. Además, se encontró el valor de sig. de 0.535 > 0.05, indicando que no existe relación significativa entre el Estilo de Crianza parental y Ansiedad Rasgo. Además, respecto a las dimensiones Compromiso y Autonomía Psicológica se halló relación significativa con la ansiedad estado y ansiedad rasgo. Las conclusiones precisan que existe relación a nivel parcial en los estilos de crianza parental y la ansiedad en los estudiantes.
Influencia de la gestión del conocimiento en el desempeño laboral del personal administrativo de una Municipalidad Distrital de Lima Este (Perú), 2023
Authors:   , Cespedes Pulido Sandra
Published: October 2024

En un mundo cada vez más competitivo, la gestión del conocimiento se ha convertido en un factor clave para el desempeño laboral en las organizaciones del siglo XXI. La presente investigación tuvo como objetivo determinar la influencia de la gestión del conocimiento en el desempeño laboral del personal administrativo de una municipalidad distrital de Lima Este (Perú), 2023. Para lograr un mejor análisis, se desglosó la variable gestión del conocimiento en tres dimensiones: capacitaciones, aprendizaje organizacional y gestión por competencias: por otro lado, la variable desempeño laboral se subdividió en otras tres dimensiones: eficiencia, manejo de habilidades y capacidades. La investigación se desarrolló bajo el enfoque cuantitativo, alcance correlacional y utilizó el diseño no experimental transeccional correlacional-causal; los participantes fueron 70 trabajadores administrativos de la municipalidad distrital objeto de estudio a los cuales se les aplicó un cuestionario tipo Likert compuesto por 22 ítems. Los resultados revelaron que la gestión del conocimiento influye significativamente en el desempeño laboral, con un coeficiente de Nagelkerke de 0.565. Asimismo, se detectó una influencia positiva de dicha variable en la eficiencia y manejo de habilidades con coeficientes de Nagelkerke de 0.867 y 0.581 respectivamente. Sin embargo, existe una brecha en la capacidad del personal (coeficiente de Nagelkerke de 0.391) para resolver problemas y alcanzar los objetivos de la entidad, lo que resalta la necesidad de mejorar los métodos de generación de conocimiento, enfatizando el papel crucial de la gestión del conocimiento en el sector público y proporcionando perspectivas valiosas para futuras políticas y prácticas.
Emprendimiento sostenible y compromiso social de la empresa Cofaco Industries S.A.C. (Lima-Perú), 2022
Authors:   , Arista Cancino Claudia Lucia
Published: October 2024

El estudio analiza la relación entre el emprendimiento sostenible y el compromiso social de la empresa textil COFACO Industries S.A.C.; es decir, la responsabilidad voluntaria de la empresa para aliviar necesidades del mercado con un modelo de negocio sustentable. Para ello, se aplicó una encuesta a 246 colaboradores con una metodología de diseño no experimental y enfoque cuantitativo, logrando una significancia del Alfa de Cronbach de 0.816 y 0.846 respectivamente. Como resultado, el coeficiente Rho de Spearman mostró una correlación moderada alta para las hipótesis planteadas, corroborando que es importante una gestión adecuada del emprendimiento sostenible en sus tres dimensiones para el desarrollo del compromiso social de la empresa, favoreciendo la identificación de nuevas oportunidades y tendencias que favorezcan su competitividad sin perjudicar las necesidades sociales futuras.
Deprescribing Anticholinergics to Preserve Brain Health: Reducing the Risk of Dementia through Deprescribing (R2D2): Study Protocol for a Randomized Clinical Trial
Authors: Campbell Noll L. , Holden Richard J. , Gao Sujuan , Unverzagt Frederick W. , Lane Kathleen A. , Carter Allie , Harrington Addison B. , Manoharan Sneha , Manoharan Neha , Rosenthal Danielle L. , Pitts Christopher , Pelkey Kathryn , Papineau Emily , Lauck David A. , Keshk Noha , Alamer Khalid , Khalil Hussein , Boustani Malaz A.
Published: October 2024

Background: Older adults commonly experience chronic medical conditions and are at risk of cognitive impairment as a result of age, chronic comorbidity, and medications prescribed to manage multiple chronic conditions. Anticholinergic medications are common treatments for chronic conditions, and have been repeatedly associated with poor cognitive outcomes, including delirium and dementia, in epidemiologic studies. However, no study has definitively evaluated the causal relationship between anticholinergics and cognition in a randomized controlled trial design. Utilizing our prior experience in deprescribing anticholinergic medications in various clinical environments, we designed an outpatient deprescribing intervention to prospectively test the potential causal relationship between anticholinergics and cognition in primary care older adults.
Methods: This cluster randomized clinical trial will be conducted to evaluate the impact of an anticholinergic deprescribing intervention compared to usual care on outcomes of cognition and safety in primary care older adults. Participants will include those aged 65 years and over, receiving primary care in the greater Indianapolis area, using a strong anticholinergic within the last two weeks or with evidence of high-risk exposure in the past year. Those excluded will have a diagnosis of Alzheimer’s disease or related dementia, or serious mental illness. The trial plans to enroll 344 participants who will be cluster-randomized at the level of primary care physician to avoid contamination. Participants will complete outcome assessments every six months up to 2 years by blinded outcome assessors. The primary outcome of the study is a composite measure of cognition that includes domains assessing executive cognitive function, language, and memory. Secondary outcomes include patient-reported measures of pain intensity, depression, anxiety, sleep disturbance, and health-related quality of life.
Discussion: The R2D2 trial will be the largest and longest prospective randomized trial testing the impact of an anticholinergic-specific deprescribing intervention on cognition in primary care older adults. Results could influence deprescribing methodology and provide new insight on the relationship between anticholinergics and cognition.
Trial Registration:
Trial Registration: clinicaltrials.gov, NCT04270474. Registered17 February 2020.
Cs-promoted Active Species for Ag-catalyzed Ethylene Epoxidation
Authors: Wu Kai , Zhang Yuchen , Pan Jinliang , Li Xiu-e , Wu Zi-ang , Zhang Rankun , Chen Qiwei , Song Fei , Zhang Hui , Wen Xiao-Dong , Li Yong-Wang , Yin Junqing , Zhou Xiong
Published: October 2024

Ethylene epoxidation on Ag catalysts is a fundamental reaction in chemical industry. Although electrophilic oxygen species are previously attributed as potential active species for this reaction, their precise structure and formation mechanisms have remained unsolved. In this study we have revealed that Cs promotes the formation of an unreported zigzag [1-10] Ag-O chain on Ag(110) surface. This chain characteristic of electrophilic oxygen and embedded Ag dimers, in sharp contrast with the [001] Ag-O chains which comprise nucleophilic oxygen and form in the absence of Cs. Further experiments have shown that the electrophilic oxygen with neighboring Ag dimers together serves as the active species for completely selective production of ethylene oxide. However, the [001] Ag-O chains predominantly react with ethylene to form water. Theoretical calculations further corroborate that the oxametallacycle intermediate is stabilized due to the matching of the frontier orbitals between ethylene and the [1-10] Ag-O chain and responsible for the distinct selectivity observed in these Ag-O chains. This atomic-scale understanding of the active species in ethylene epoxidation necessitates reassessing the role of alkali metals in catalysis and developing strategies to enhance the selectivity of the ethylene epoxidation process.
Efficient removal of Pb(II) from aqueous solutions using chitosan-based hydrogels: PCG and PCC, adsorption performance and mechanism studies
Authors: Sun Jingyu , liang lili , Pan Huanying , Zheng Zhenzhen , Liu Xin , Cao Xinyu
Published: October 2024

Lead (Pb) is a highly toxic and persistent pollutant that poses a significant threat to human health, making the remediation of lead-contaminated water bodies an urgent priority. In this study, chitosan and acrylic acid were employed as base materials, with graphene oxide (GO) and carboxylated graphene (GC) acting as crosslinking agents to synthesize two novel chitosan-based hydrogels (PCG and PCC). Both PCG and PCC were characterized and subjected to systematic static adsorption experiments. Further investigations focused on PCC, examining the effects of coexisting ions and organic substances (humic acid and fulvic acid), adsorption-desorption cycles, and dynamic column experiments to assess its applicability in complex water environments. The results indicated that under the conditions of pH 4.72, temperature of 25°C, dosage of 0.2 g/L, and an initial concentration of 500 mg/L, PCG and PCC achieved maximum adsorption capacities of 323.83 mg/g and 446.09 mg/g, respectively. PCC exhibited excellent resistance to ion interference and demonstrated good reusability. Additionally, in dynamic column experiments with an influent flow rate of 2 ml/min and a hydrogel dosage of 200 mg, PCC effectively treated simulated wastewater with concentration of 50 mg/L for over 900 minutes. These findings indicate that the developed hydrogels exhibit great potential for large-scale application in the market.
Echocardiographic parameters for evaluating coarctation of the aorta before and after birth: A meta-analysis
Authors: Yuan Chen , Maimaitituergan Ayijibaike , Guan Lina , Mu Yuming
Published: October 2024

Objective
To investigate the diagnostic value and correlation strength of echocardiographic parameters in evaluating and predicting fetal coarctation of the aorta (CoA).
Methods
PubMed, Web of Science, GeenMedical, The Cochrane Library, CMB, CNKI, Wanfang, and VIP were searched to obtain all data on the echocardiographic diagnosis of aortic coarctation collected from the database to December 1, 2023. Related literature. The quality of the included literature was evaluated using the QUADAS-2 risk assessment standard provided by Revman 5.3 statistical software. The majority of the parameters were analyzed by the Z-score and the corresponding ratio. The results were analyzed using Stata15.1 software, which combined sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) for the data that were pooled. The diagnostic odds ratio (DOR) and publication bias analysis were performed for all included studies.
Results
A total of 17 studies were included containing a total of 1,373 patients. The mean mitral valve diameter Z score, ascending aorta Z score, ascending aorta diameter, aortic isthmus mean diameter Z score ( Three-vessel tracheal section), and ductus arteriosus/aortic isthmus diameter (P < 0.05) of the fetuses with aortic coarctation were lower compared with those of the normal fetuses (P = 0.007, P = 0.032, P = 0.006, P = 0.011, P = 0.019, respectively). The aortic isthmus/ductus arteriosus (diameter, mm), mean pulmonary valve diameter Z score, right ventricle/left ventricle (diameter), and right ventricle/left ventricle (area) were higher than those noted in normal fetuses (P = 0.455, P = 0.557, P = 0.408, P = 0.522, respectively). The echocardiographic parameter of neonates and infants was the carotid-subclavian artery index. Following combination of the data, the following results were obtained: Sensitivity: 0.90 (95% CI: 0.72–0.97), specificity: 0.97 (95% CI: 0.92–0.99), positive likelihood ratio: 26.7 (95% CI: 10.7–66.5), negative likelihood ratio: 0.10 (95%CI: 0.03–0.32), diagnostic odds ratio: 262 (95% CI: 37-1875), subject area under the operating characteristic curve (AUC): 0.98.
Conclusion
For fetuses at risk, the cardiac parameters of the aforementioned ultrasound signs can be more accurately evaluated and can predict the occurrence of CoA before and after birth.
Trust, Autonomy, and Teaching Dynamics in Robotic Surgery: A Mixed Methods Study
Authors: Aoun Rami James N. , Nyein Kyi Phyu , Huang Emily
Published: October 2024

Purpose
Compared to open or laparoscopic surgery, the configurational relationship between trainer and trainee in robotic surgery reduces face-to-face interaction and ability to directly co-manipulate the surgical field. To elucidate the impact of this environment on surgical training dynamics, we conducted a mixed-methods study examining dyadic trust, autonomy, teaching, communication, and feedback in robotic surgery.
Methods
Robotic procedures performed on a dual console system at a single academic center were included. Trainee console operative time, representing autonomy, was extracted from the robotic system. Bidirectional trust was measured via a modified Leader Member Exchange (mLMX) questionnaire at the end of each case. Correlation between autonomy and trust was analyzed utilizing Pearson’s coefficient. Procedures were video- and audio-recorded, capturing both endoscopic view and a broad view of the operating consoles with trainer/trainee interactions. Two researchers performed thematic analysis of the synchronized video and transcribed audio.
Results
Nine robotic procedures in colorectal, general surgery, urology, and thoracic surgery were included. Trainee console time was directly correlated with average trainer mLMX trust scores (r=0.54) but not trainee scores (r=-0.19). Average trainer mLMX trust score was 4.08 vs. 3.16 (p=0.038) for trainees with >50% vs. <50% console time; trainee mLMX was not significantly different between the same groups (p=0.74). Thematic analysis revealed major themes of effective teaching techniques, feedback “escalation,” and trust-fostering behavioral strategies.
Conclusion
Higher trainer trust is associated with higher resident autonomy, and trainers/trainees can use specific strategies for teaching, feedback, and fostering trust in the robotic operating room. These findings may improve communication and trainee autonomy in the robotic operating room, and inform future robotic surgical educational curricula.
Antimicrobial Activities of Bio-Oil and Bio-Tar Obtained from Pyrolysis of Cocoa Pod Husk (Theobroma Cacao L.) on Some Selected Pathogenic Organisms
Authors: Adesemuyi Mibinuola Florence , Adeyemo Adebayo Jonathan , Akinola Adebisi Olayinka , Ogundele Joan Olayinka , Olasupo Abdulhakeem Dapo , Adeyemi Daniel Olusegun , Lajide Labunmi
Published: October 2024

The use of synthetics antibacterial and antifungal activities of bio tar and biological oil obtained via cocoa pod husk were investigated on seven selected bacteria; Erwinia carotovora, Corynebacterium sopedonium, Staphylococcus aureus, Pseudomonas solanacearium, Salmonella typii, Xanthomonasphaseoli, Clavbactermichinganensi and five selected fungal; Phytophthora megacarrier, Fusarium vasinfectum, Collectotrichum lindinuthianum, Glomerella gossypii, Cercospora sojina isolates, employing the procedures for food poisoning and agar culture dispersion, accordingly, Findings from antimicrobial activity indicated that the bio-oil as well as the bio-tar performed reasonably well against all the isolates with a zone of inhibition ranged from19.17 ± 1.04g to 35.77 ± 0.25c mm. The results of antifungal activities showed that the percentage of mycelia growth inhibition ranged from 80.35 to 99.33% against the isolates compared to the standard Mancozeb (control). The biological oil and biotar from cocoa pods husks were pyrolyzed at 400°C and their antifungal activity was noticeably higher than their antibacterial activity.
Prevention of Acid Rock Drainage formation through pyrite inhibition by silica coating
Authors: Butar Dantie Claudia Butar , Alakangas Lena , Kaasalainen Hanna , Ronne Erik
Published: October 2024

Passive treatment of acid rock drainage (ARD) has been considered a sustainable approach in the long term, with sulfide inhibition by silica being a promising alternative. In a small-scale column leaching, a total of four cells loaded with pyritic waste rock (11 wt.% S) from an operating Cu mine in Sweden were kept in a climatic chamber at a controlled temperature and humidity. The waste rock was subjected to a water-leach for 11 weeks before treatment using alkaline silicate solution was applied, without pH buffer and adjuster. One cell was left untreated, whereas the others were treated with silicate solution as a source of dissolved silica, with and without H2O2 pre-oxidation. The pH in silica-treated cells generated leachate with circumneutral pH until the end of the leaching cycle, whereas sulfide oxidation accelerated in the absence of treatment. Leachate quality in all Si-treated cells improved, as evidenced by the suppressed release of sulfur and other metals (e.g. Al, Fe, Cu, Co, Mn, and Ni). Silica (SiO2) layer developed on waste rock upon treatment with a longer contact time, which remained stable upon extended exposure to air and water up to 10 weeks after treatment. Pyrite inhibition is attributed to the formation of silica layer. Despite forming a siliceous Fe-O phase, H2O2 pre-oxidation resulted in indirect oxidation of sulfides and other phases. With an excess of silicate solution and at alkaline pH, pyrite surfaces are devoid of coating and metal ions were mobilized. Finally, this study suggested that treatment of pyritic waste rock using silica can attenuate ARD formation and prevent metal leaching by pyrite inhibition and maintaining a circumneutral pH environment or both.
Alcohol Use and Sexual Functioning: A Study of Adult Males in Primary Care
Authors: Esangbedo Arit , Okonkwo Chinyere , Ajayi Oluwatomiwa , Ebeiyamba Okon Ekpo
Published: October 2024

This study examined the prevalence, risk factors, and healthcare implications associated with alcohol use and sexual functioning among adult male primary care patients. The study focused on a sample of over 2,100 men and utilized comprehensive assessments of sexual functioning and alcohol use to assess the associations in a variety of domains. It adopted a Cross-Sectional approach involving sexually active adult males from 18–40 years old in a relationship, who drink alcohol at least twice per week. Study instruments used include the Proforma, IIEF, AUDIT etc. It used the finite population correction factor statistic to determine the right sample size, taking into account the size of the population which resulted in a more accurate estimate of the population parameter of interest. Analysis was carried out with statistical package for social sciences (SPSS) at a 95% confidence interval. From the study results, a considerable number of male participants, approximately 25%, were found to have alcohol use disorders, and 44.2% of them reported experiencing sexual dysfunctions. Furthermore, the research findings suggested that advancing age was associated with an increased risk of problematic alcohol use, whereas lower income was linked to a higher likelihood of sexual dysfunction. Most significantly, the research found a connection between sexual dysfunction and the consumption of alcohol. Individuals who consumed alcohol excessively had notably reduced sexual functioning overall, including impaired erectile and ejaculatory function, as well as a decreased sexual desire. This highlights the need for comprehensive assessment and targeted interventions to improve the health of men in primary care, which should include alcohol use screenings and interventions as well as sexual health care. The implications of this study are that men who consume alcohol are exposed to increased risks of impaired sexual functioning. As such, primary care providers should be aware of the risks and consider the implementation of alcohol use assessments and appropriate interventions to improve their patient’s health outcomes. Additionally, educational programs should be implemented in order to increase awareness of the risks associated with alcohol use and sexual functioning among men in primary care.
A novel nomogram for predicting the implementation of ultra-fast-track cardiac anesthesia for minimally invasive cardiac surgery
Authors: Jiang Tian , Xu Linting , Wang Haozhou , Zheng Qinghui , Zhang Yihui , Lou Xiaokan , Guo Jinchen , Wei Hanwei , Yan MeiJuan
Published: October 2024

Background
Ultra-fast-track cardiac anesthesia (UFTCA) is a crucial component of Enhanced Recovery After Cardiac Surgery (ERACS). However, research on the factors influencing UFTCA implementation remains limited. This study aimed to identify predictors of UFTCA in right-thoracoscopic minimally invasive cardiac surgery (MICS) and develop a nomogram to forecast UFTCA implementation.
Methods
This retrospective study included 947 patients who underwent right-thoracoscopic MICS from January 2021 to July 2023. Patients were randomly divided into derivation (70%) and validation (30%) cohorts. Univariable logistic regression analysis was used for variable selection, followed by a multivariable logistic regression model to determine significant predictors and construct a nomogram for forecasting UFTCA implementation. The model's discrimination, calibration, and clinical usefulness were evaluated using the validation cohort.
Results
Multivariate analysis identified six independent predictors of UFTCA implementation: operation type, fascial plane chest wall blocks (FPCWB), intraoperative sufentanil and dexamethasone dosage, operation later than 8 p.m., and cardiopulmonary bypass (CPB) duration. The nomogram demonstrated good discriminative ability, with areas under the receiver operating characteristic (ROC) curve of 0.869 and 0.862 for the derivation and validation sets, respectively. The calibration plot showed close alignment with the ideal diagonal line, and the decision curve analysis (DCA) confirmed the model's clinical practical significance.
Conclusion
This study developed and validated a nomogram that could predict the implementation of UFTCA in patients undergoing MICS. The identified predictors, including operation type, FPCWB, intraoperative sufentanil and dexamethasone dosage, operation later than 8 p.m., and CPB duration, could guide clinicians in decision-making to facilitate UFTCA implementation.
Accounting for Albedo in Carbon Market Protocols
Authors: Riley Lynn , Cook-Patton Susan , Albert Loren , Still Christopher , Williams Christopher , Bukoski Jacob J.
Published: October 2024

Although natural climate solutions (NCS) are increasingly deployed within carbon markets and beyond, their climate benefits may be over-estimated due to a lack of accounting for changes in albedo. Here we analyze 172 Afforestation, Reforestation, and Revegetation projects within the voluntary carbon market and find more than 10% occur in places where albedo entirely negates the climate mitigation benefit and a quarter occur in places where albedo halves the mitigation benefit. Yet, the majority of projects are concentrated where albedo changes are expected to be minimal, and 9% of projects occur where albedo would augment the mitigation benefit. New data make albedo accounting possible for the first time, and we outline an iterative approach for incorporating albedo considerations into carbon crediting protocols. Doing so will enable prioritization of projects with greater climate benefit and more accurately quantify credits that may be used to address unabated emissions.
The relationship between occupational future time perspective and thriving at work in nurses: A chain mediating role of job crafting and work engagement
Authors: Wang Xiao , Liu Yongmei , Chen Bifeng , Zhang Xiaoling , Chen Qiaogen , Li Yulan , Lin Xiaoha
Published: October 2024

Background: Thriving at work positively impacts nurses’ work performance, and it reduces their burnout and turnover intention. However, the relationship between occupational future time perspective (OFTP) and thriving at work has not been examined among nurses. The aim of this study was to explore the relationship between occupational future time perspective and thriving at work, and to examine the chain mediating role of job crafting and work engagement in this relationship.
Methods: This cross-sectional study involving 233 nurses was conducted via an online survey in a tertiary teaching hospital in China. Thriving at work, OFTP, job crafting, and work engagement were measured by the Thriving at Work Scale, the Occupational Future Time Perspective Scale, the Job Crafting Questionnaire, and the Utrecht Work Engagement Scale-9, respectively. The Process (version 3.5) plug-in of SPSS was used to analyze the mediation effects.
Results: The results showed that OFTP was positively associated with thriving at work (β=0.654, p<0.001) among nurses. Job crafting(effect value=0.258, Bootstrap 95% CI: 0.116, 0.427) and work engagement (effect value=0.117, Bootstrap 95% CI: 0.044, 0.208) medicated the relationship between OFTP and thriving at work, respectively. Job crafting and work engagement played a chain mediating role in the correlation between OFTP and thriving at work (effect value=0.180, Bootstrap 95% CI: 0.099, 0.275).
Conclusion: This study found that OFTP directly and indirectly affects thriving at work through job crafting and work engagement. Organizations should provide nurses with more opportunities for career development to develop their OFTP in order to motivate job crafting and work engagement, ultimately fostering thriving at work.
Identification of CENPW as a Prognostic Biomarker and Potential Therapeutic Target for Clear Cell Renal Cell Carcinoma
Authors: Xiao Haibing , Xu Qili , Gao Yu , Wu Weikang , Wang Baojun , Li Haolin , Fei Mintian
Published: October 2024

Centromere protein W (CENP-W) is essential for chromosome segregation and mitotic assembly and has been recognized as a prognostic marker in several cancers. However, its significance in clear-cell renal cell carcinoma (ccRCC) remains underexplored. To address this, we analyzed ccRCC transcriptomic data from the National Center for Biotechnology Information (NCBI) and The Cancer Genome Atlas (TCGA) to evaluate CENP-W expression and its associations with clinical outcomes, prognosis, and immune-related markers. Kaplan-Meier survival analysis revealed that elevated CENP-W levels are linked to poorer overall survival in ccRCC patients. Further meta- and multivariate analyses confirmed CENP-W as an independent negative prognostic factor. Gene Set Enrichment Analysis (GSEA) revealed the involvement of CENP-W in immune-related pathways, notably PI3K-Akt and Wnt signaling. Pearson correlation analysis demonstrated a significant association between CENP-W expression and immune cell infiltration, cancer-associated fibroblasts (CAFs), CTLA4, and PDCD1. qRT-PCR assays confirmed elevated CENP-W levels in ccRCC samples. Additionally, GSEA and GO enrichment highlighted a relationship between CENP-W and lipid metabolism, where reduced CENP-W expression led to a significant decrease in lipid droplet accumulation. This study identifies CENP-W as a potential biomarker and prognostic indicator in ccRCC, offering insights into personalized therapeutic strategies integrating tumor immunity to enhance immunotherapy efficacy.
Lived Experiences of Caregivers of Paediatric Patients Diagnosed with Cancer at Mbarara Regional Referral Hospital, Mbarara district, Uganda: A qualitative study
Authors: Asiimwe Gloria Suubi , Isiko Isaac
Published: October 2024

Background
Psychosocial and economic hardships represent a constant challenge for those living with children diagnosed with cancer. Biomedical implications for paediatric patients and caregiving add to their distress. The purpose of this study was to explore the lived experiences of caregivers of paediatric patients diagnosed with cancer at Mbarara Regional Referral Hospital (MRRH).
Methods
This was a qualitative study in which in-depth interviews with 10 purposively selected paediatric caregivers at the oncology unit of MRRH were conducted. The data were analysed via thematic content analysis.
Results
The majority of the caregivers enrolled in the study were mothers of pediatric patients, whereas a few were fathers and siblings (sisters). The lived experiences of the caregivers were grouped under different themes, each with subthemes. Psychological distress as a result of the cancer diagnosis and its treatment modalities, with subthemes of confusion, depression, social isolation and financial strain. Satisfaction with healthcare providers’ practices is a theme. Sociocultural beliefs with subthemes of misconceptions and myths. Coping strategies as a theme with the subthemes of sharing care, seeking divine intervention and making sacrifices.
Conclusions
This study highlights some of the psychosocial and financial needs of caregivers of paediatric patients with cancer at MRRH, highlighting the need for holistic care involving paediatric cancer patients and their caregivers.
Pulsed Electrosynthesis of Glycolic Acid through Polyethylene Terephthalate Upcycling over a Lamellar Mesoporous PdCu Catalyst
Authors: Liu Ben , Han Shu , Sun Lizhi , Fan Dongpin
Published: October 2024

Electrocatalytic upcycling of polyethylene terephthalate (PET) plastics offers a promising and sustainable route that not only addresses serious waste pollution but also produces high value-added chemicals. Despite some important achievements, their activity and selectivity have remarkably been slower than needed. In this work, pulsed electrocatalysis was employed to engineer chemisorption properties on a lamellar mesoporous PdCu (LM-PdCu) catalyst, which delivered superior activity and stability for selective electrosynthesis of high value-added glycolic acid (GA) from PET upcycling under ambient conditions. LM-PdCu was synthesized by in situ nucleation and attachment strategy along assembled lamellar templates, whose stacked morphology and lamellar mesoporous structure kinetically accelerated selective desorption of GA and exposed fresh active sites of metal catalysts for continuous electrocatalysis at pulsed mode. This strategy thus delivered impressive GA Faraday efficiency of > 92% in wide potential windows, high yield rate of reaching 0.475 mmol cm–2 h–1, and excellent cycling stability of exceeding 20 cycles for electrocatalytic PET upcycling, outperforming previously reported values. Moreover, pulsed electrocatalysis disclosed good electrocatalytic performance for scaled-up GA electrosynthesis from real bottle waste plastics. This work provides a sustainable and highly potential route for selective electrosynthesis of value-added chemicals from upcycling of various waste feedstocks.
Poly-ε-caprolactone/chitosan/Whitlockite Electrospun Bionic Membrane conjugated with an E7 peptide for bone regeneration
Authors: Chen Guangzi , Xu Tao , Gao Ran , Liu Wenbin , Li Weigang , Zeng Delu , Li Jian , Fang Xuan , Sheng Gaohong , Zhao Hongqi , Liu Chaoxu
Published: October 2024

Background: Periosteum plays an important role in bone defect repair due to its rich vascular network and cells. However, natural periosteum is difficult to meet clinical requirements due to its low availability. Therefore, it is necessary to develop a tissue engineering strategy of biomimetic periosteum for bone defect repair.
Methods: Poly-ε-caprolactone/chitosan/Whitlockite electrospun bionic membrane (PCL/CS/WH) was prepared using electrospinning technology, then it was conjugated with an E7 peptide as PCL/CS/WH/E7 bionic membrane. The physical properties of the membranes were evaluated by TEM and FTIR. In vitro, LIVE/DEAD staining and Cell Counting Kit-8 assay of bone marrow mesenchymal stem cells (BMSCs) and Endothelial progenitor cells (EPCs) are used to assess the biocompatibility of bionic membranes. Matrigel was applied to evaluate the ability of the different composite nanofibers samples to promote angiogenesis. Mineralized nodule and collagen formation in the BMSCs was detected by alizarin red staining and sirius red staining respectively.
In vivo, the ability of PCL/CS/WH/E7 membrane to promote bone regeneration and angiogenesis was assessed by Micro-CT and associated staining.
Result: The addition of chitosan (CS) and E7 peptide (E7) enhanced the hydrophilicity and cytocompatibility of pure PCL membranes. Additionally, CS, E7 and Mg2+ released from Whitlockite (WH) had a synergistic effect to promote angiogenesis and osteogenic differentiation. Three weeks after implantation, the membrane successfully bridged the bone defect and significantly promoted the formation of new bone and blood vessels.
Concultion: The PCL/CS/WH/E7 membrane to achieve efficient repair of bone tissue and enriches clinical solutions for the treatment of critical bone defects.