bluuebunny/crossref_metadata_2025 huggingface dataset:
Combinatorial Methods of Geometric Reasoning in CAD-Systems. A Review
Authors:   Bauman Moscow State University, Moscow, Bozhko A. N. , Rodionov S. V. ,   Bauman Moscow State University, Moscow
Published: March 2022

The article is devoted to modeling the geometric reasoning of complex scenes in computer-aided design systems. When developing complex processes and systems, obstacle analysis must be performed with high accuracy for a large number of design alternatives. The classical methods of collision detection, motion planning and virtual reality are very computationally expensive. Combinatorial methods are widely used in modern design systems. As a rule, they give easily computable necessary conditions for geometric reasoning, which makes it possible to discard obviously unrealizable design options. The article provides an overview of the most famous methods of this class.
An Integrated Approach to Assessing the Digital Maturity of an Industry
Authors:   Kazan State Power Engineering University, Kudryavtseva S. S. , Klinov A. V. ,   Kazan State Power Engineering University, Telyakov E. Sh. ,   Kazan State Power Engineering University, Laptev A. G. ,   Kazan State Power Engineering University
Published: March 2022

A methodology for calculating an indicator for assessing the aggregate level of digital maturity of an industry is proposed and its approbation is carried out on the example of the industrial complex of Russia. The proposed methodology includes such stages as descriptive statistics of local indicators of industry digitalization, factor and component analysis, calculation of an indicator for assessing the aggregate level of digital maturity of an industry based on weight coefficients and analysis of its dynamics. The method for calculating the indicator for assessing the aggregate level of digital maturity of an industry proposed in the article can be considered as a toolkit for improving the assessment of the digital transformation of an industrial complex.
Numeracy Skills Disorders: Review of Causes and Neuropsychological Mechanisms of Dyscalculia
Authors: Glinik O.A.
Published: March 2022

The article presents a review of foreign studies on the numerical difficulties and numerical disorders. The main modern theories of the mechanisms underlying the difficulties and disorders of counting are reflected, various classifications of dyscalculia are compared, and the neuropsychological foundations of the brain organization of counting are analyzed according to foreign scientists. It is noted that in the world of psychological science, the issues of the causes and mechanisms of difficulties and disorders of counting are still insufficiently developed, and the results of empirical researches are contradictory. It is concluded that for further study of dyscalculia it is necessary to analyze the psychological structure of counting and its changes under the influence of learning, taking into account the structural and functional features of the brain organization of quantitative information processing.
Subjective Predictors of Psychological Well-being of Gifted Adolescents
Authors: Volkova E.N. , Miklyaeva A.V. , Khoroshikh V.V.
Published: March 2022

Тhe paper presents the results of empirical verification of the theoretical model of subjective predictors for the psychological well-being of gifted adolescents, including subjectivity, hardiness, self-efficacy, the general emotional background, represented by the level of personal anxiety, and characteristics of the self-concept of adolescents.It was assumed that the factors moderating the relationship of these variables are the attitude of adolescents to their own giftedness, as well as the specificity of the activity in which adolescents show signs of giftedness, and the level of their achievements in it.The sample consisted of 422 adolescents aged 15–17 years enrolled in specialized educational programs for adolescents who show academic, mathematical, leadership and sports talent.The collection of empirical data was carried out using questionnaires and testing (Scale of psychological well-being; Frankfurt scales of self-assessment; Questionnaire of subjectivity; Test of hardiness; The self-efficacy scale; Test for determining self-efficacy; Integrative test of anxiety).Structural equation modeling was done using the IBM SPSS Statistics ver.23 software package and the AMOS module made it possible to recognize subjectiveness (p<0.001), the psychological well-being of gifted adolescents and the influence subjectivity and hardiness is mediated by the attitude of adolescents to their own giftedness (p<0.01), which, in turn, is determined by the level of their achievements (p<0.01).The characteristics of the self-concept, as well as such factors as "the type of activity in which the signs of giftedness are manifested" and "gender", were not included in the empirical model.The prognostic potential of the model and the possibility of solving on its basis the tasks associated with the psychological support of the personal development of gifted adolescents are discussed.
The Reflexive Aspect of the Perception of Each Other by the Subjects of the Conflict
Authors: Anikina V.G. , Lagutin A.V.
Published: March 2022

The reflexive aspect of the perception of the subjects of the conflict became the main issue of the presented work. In the framework of the experimental study, the level of reflexivity (A.V.Karpov), the styles of leading behavior (the Thomas-Kilmann Method), as well as the assessment of the personality image (the Petrovsky-Uvarina Scaling Method) were diagnosed.The experiment was carried out using the created installation "Experiment for the Study of Negotiations" (the idea by V.A.Lefebvre, modification by B.I.Khasan).It was shown that the opponent's image significantly changes for respondents with a " low" level of reflexivity. Respondents with a "high" level of reflection are more differentiated in their assessment of the opponent in the conflict interaction. The change in the opponent's image is carried out to a greater extent by the respondents who end the conflict interaction with a compromise. It was revealed that a change in the leading behavior in a conflict is more typical for respondents with "medium" and "high" levels of reflection. A statistically significant positive relationship was determined between the level of reflexivity and a change in the style of behavior in the conflict interaction. The results obtained in the future will make it possible to simulate the process of getting out of the conflict and use the potential of virtual reality to work with conflict situations.
The Impact of Dopamine Receptor Signaling on Myeloid Cell Function
Authors:   , Nickoloff-Bybel Emily Anne , Gaskill Peter J , Barker Jacqueline M
Published: March 2022

Up to 50% of people living with human immunodeficiency virus, or HIV (PLWH) suffer from some form of neuroHIV, the collection of distinct neuropathologies and neurocognitive impairments associated with HIV infection of the central nervous system (CNS). Current data suggests comorbid substance use, which is disproportionately high in people living with HIV (PLWH), can enhance HIV neuropathogenesis. All substances of abuse increase extracellular dopamine levels in the CNS, and dopamine rich regions of the CNS are particularly sensitive to HIV-associated inflammation and neuronal dysfunction. This suggests that elevations in CNS dopamine are one way in which drugs of abuse can impact neuroHIV. Dopamine is an important neuroimmune modulator and impacts the function of a number of immune cells, including cells of the myeloid lineage. Myeloid cells, primarily macrophages and microglia, are the major producers of virus within the CNS and critical drivers of neuroinflammation. We have shown dopamine increases HIV replication and inflammation in human macrophages, but the mechanism by which it does so is not clear. Here, we expand on these findings and demonstrate that in macrophages, dopamine increases HIV entry through a calcium dependent mechanism mediated, in part, by coupling of the D1-like receptors to Gq. Further, we show that dopamine does not act through NFkB to drive pro-inflammatory cytokine release in microglia, demonstrating differences in dopamine-mediated inflammation between macrophages and microglia. Mechanistically, these differences may be driven by distinct dopamine-receptor pathways. In macrophages, dopamine acts primarily through Gq-PLC-beta to drive calcium release, PKC activation, and AKT phosphorylation, while in microglia, dopamine acts through Gs-cAMP and has an inhibitory effect on AKT. These studies provide evidence that differences in dopamine signaling can impact dopamine's effects on HIV neuropathogenesis, and suggest new pathways that could be therapeutically targeted in the treatment of HIV neurocognitive disorders.
No More 10 Out of 12s
Authors:   , Richardett Tanner A. , Almanzar Salina
Published: March 2022

In American theatre, the term "10 out of 12" describes a lengthy technical rehearsal day involving 10 hours of work onstage with a two-hour break. Demands for the abolition of this practice arose from the likes of We See You, White American Theatre and No More 10 Out of 12s amid the COVID-19 pandemic and social reckonings of the summer of 2020. The demands illustrate how the practice of 10 out of 12s is rooted in White supremacy in theatre, anti-safety, ableist, anti-caregiver, and negatively impactful on the quality of life of theatre artists. In a mixed quantitative and qualitative survey distributed to the theatre community in Philadelphia, a significant majority of participants affirmed the need to remove these practices from our traditional workflow. The results also affirmed the presence of each of the five rationales provided by these movements. The survey results provide an initial understanding of the favorability of the Philadelphia theatre community to abolish these practices while also providing raw and honest descriptions of hardships faced while working under these conditions. More research should be conducted in other metropolitan theatre communities and the American theatre sector as a whole to determine other regional and national sentiments towards these practices. By understanding the stance of the community at large, the American theatre sector can continue to move forward towards a more equitable work environment and out of its roots that idealized White and able-bodied artists.
Investigating emotional intelligence in mild-moderate TBI
Authors:   , Williams Rebecca B. , Schultheis Maria Teresa
Published: March 2022

The current study aims to determine whether an overarching construct, emotional intelligence (EI), is a deficit in mild-moderate TBI compared to a healthy population. Further, this study aims to elucidate the relationship between EI and cognition in this population, and also to investigate the contribution of EI to psychosocial outcome. There is consistent evidence of psychosocial impact of mTBI within the literature, such as the decline in the quality of romantic relationships, the quantity and nature of friendships, and community involvement in general. This is the case despite the heterogeneous definition of the condition among studies. Although many studies report cognitive symptoms in mTBI resolving within 6-months post-injury, unwelcome changes in personality and psychosocial functioning in this population have been reported by patients and their relatives long after the initial injury, across severities. EI has been argued to be a magnifying glass to individual differences, accounting for what cognition cannot in one's emotional and behavioral abilities. The present study investigated the contribution of EI to psychosocial outcome, particularly difficulty maintaining employment, in the years following mTBI. This study did not reveal significant differences in EI between mild TBI and healthy control participants. However, individual analyses revealed significant differences in overall EI and EI factors in select mTBI participants. A significant relationship was found across groups between performance on executive functioning and EI, as well as presenteeism and EI. While this study is limited by small sample size, heterogeneity of the population, and limited assessment, the findings support a relationship between EI and executive functions, as well as job performance. Future studies would benefit from a larger sample size and a nuanced assessment of executive functions, as well as multiple measurements of EI.
Análise das Manifestações Patológicas no Prédio da Faculdade Pitágoras em Aracati-CE
Authors: Maia Gabriela Maria Silva , Roncari Nascimento Bene
Published: March 2022

ResumoNo Brasil, é cada vez maior a quantidade de construções feitas em grande escala e em curto espaço de tempo. A falta de uma execução adequada e que atenda às exigências de qualidade e durabilidade em edificações, tanto residenciais como comerciais, vem ocasionando uma grande quantidade de manifestações patológicas nessas construções. Desta forma, o presente trabalho apresenta o levantamento e a análise das principais manifestações patológicas observadas no prédio onde se encontra instalada a Faculdade Pitágoras em Aracati-Ce. Foram utilizadas como metodologia, vistorias através da observação direta, a fim de realizar o levantamento e registrar as principais informações. Estas foram feitas por meio de fichas, fotografias e representações gráficas dos elementos. De acordo com o levantamento feito, os principais problemas encontrados foram trincas e rachaduras partindo de elementos estruturais, fissuras nas alvenarias, descolamento de cerâmica e descascamento de tinta em algumas paredes.
Palavras-chave: Caracterização de Danos. Eflorescência. Fissuras. Construção. Danos.
AbstractIn Brazil, there is an increasing number of constructions made on a large scale and in a short period of time. The lack of an adequate execution that meets the demands of quality and durability in buildings, both residential and commercial, has caused a large number of pathological manifestations in these constructions. Thus, the present study presents the survey and analysis of the main pathological manifestations observed in the building where the Pitágoras School is located in Aracati-Ce. Surveys through direct observation were used as methodology, in order to carry out the survey and record the main information. These were made by means of tokens, photographs and graphic representations of the elements. According to the survey, the main problems encountered were cracks and cracking from structural elements,fissure in masonry , ceramic peeling and paint peeling on some walls.
Keywords: Damage Characterization. Efflorescence. Cracks. Construction. Damage.
Química Forense: A Ciência e sua importância para a sociedade
Authors: Santos Caio Delano Couto , Henrique Barbosa Sabino Carlos , Pereira Caroline Ramos , Queiroz Thauany Oliveira , Mininel Francisco José
Published: March 2022

Esse trabalho é resultado de uma revisão bibliográfica através da literatura técnica, com intuito de exemplificar e pormenorizar os principais campos aplicáveis na Química Forense cujo compromisso é a resolução de qualquer tipo de ambiente criminal; evidenciando também a origem e descoberta das Ciências Forenses, assim como a relevância da aplicabilidade dessas técnicas analíticas na solução em ambientes de crimes. A metodologia adotada no este artigo consiste na seleção de quatro periódicos originais que descrevem os principais métodos investigativos em Química Forense, tais como, Análise de Drogas de abuso, Balística Forense, Datiloscopia Forense, Documentoscopia Forense e a Quimiluminescência. O trabalho de revisão evidenciou que 75% dos periódicos selecionados abordaram técnicas e estudos envolvendo as Análises de drogas de abusos (Toxicologia) e a Balística Forense, enquanto 50% dos artigos discorreram sobre a Datiloscopia Forense, Quimiluminescência e Documentocopia. Dessa forma, revisitamos o tema e, através das informações alcançadas via livros, internet e revistas, pode-se inferir a significância que a Química Forense possui nas elucidações criminais. Os estudos nessa área são de extrema importância em tempos onde o índice criminal tem aumentado de maneira gigantesca e significativa, atingindo as cidades de todos os países e continentes.
Revisitação dos Métodos de Extração de Pigmentos do Urucum
Authors: Toledo Caroline Diodato de , Teixeira Douglas Almeida , Archanjo Elisabeth da Vitória , Pereira Felipe Fernando , Siqueira Fernanda Cristina , Mininel Francisco José , Lima Jean Soares de , Silveira Kelly da Mota
Published: March 2022

ResumoOs corantes podem ser utilizados para muitas finalidades e uma grande quantidade destas são de cunho industrial, como por exemplo, a indústria de alimentos que utiliza estes corantes para conferir cores mais atrativas aos seus produtos, induzindo sua compra pelo consumidor final. O Brasil é considerado um dos maiores produtores de Urucum do mundo, visto que alguns estados brasileiros produzem a planta, sendo Rondônia o maior produtor. Mas apenas uma pequena parte dessa produção é destinada a indústria de corantes, isto deve-se ao seu alto custo de produção. Este artigo tem como objetivo o estudo das extrações da Bixina da planta Bixa Orellana, popularmente conhecida como Urucum ou Urucu, que, é um termo tupi-guarani que traduzido para a língua portuguesa significa vermelho. Analisando os três processos de extração, sendo eles a extração por imersão em solução alcalina, a Extração por imersão em óleo vegetal e a Extração por solventes orgânicos, chegou-se à conclusão de que embora a extração por solventes orgânicos facilite a obtenção do produto, é considerada pouco viável. A extração por imersão em solução alcalina é o método mais utilizado por ser possível uma obtenção do produto em maior quantidade, sendo mais viável economicamente, considerando seu alto custo.
Palavras-chave: Bixina. Corante. Extração.
AbstractDyes can be used for many purposes and a large number of these are of an industrial nature, such as, for example, the food industry that uses these dyes to give more attractive colors to its products, inducing their purchase by the final consumer. Brazil is considered one of the largest producers of Annatto in the world, since some Brazilian states produce the plant, with Rondônia being the largest producer. But only a small part of this production is destined for the dye industry, this is due to its high cost of production. This article aims to study the extractions of Bixin from the Bixa Orellana plant, popularly known as Urucum or Urucu, which is a Tupi-Guarani term that translated into Portuguese means red. Analyzing the three extraction processes, namely extraction by immersion in alkaline solution, Extraction by immersion in vegetable oil and Extraction by organic solvents, it was concluded that although extraction by organic solvents makes it easier to obtain the product, is considered not viable. Extraction by immersion in alkaline solution is the most used method because it is possible to obtain the product in greater quantity, being more economically viable, considering its high cost.
Keywords: Bixin. Dye. Extraction.
Dificuldades dos Alunos do Ensino Médio na Resolução de Problemas Propostos em Avaliações de Larga Escala: um Relato de Experiência
Authors: Santos Jose Cicero dos , Galvão Maria Elisa Esteves Lopes
Published: March 2022

ResumoNeste artigo traz-se um relato de experiência que tem por objetivo analisar as heurísticas de resolução de problemas apresentadas por estudantes da primeira série do Ensino Médio. Investigam-se as heurísticas a partir dos registros e manifestações dos participantes e busca-se verificar se as dificuldades nas resoluções possuem relação com a natureza ou com o contexto do problema. Os problemas propostos na intervenção envolveram conceitos algébricos, cálculo de área e perímetro, com natureza e contexto distintos, e foram resolvidos por um grupo voluntário de estudantes. Para analisar as respostas dos alunos, busca-se apoio nos pressupostos teóricos da heurística de resolução de problemas do Schoenfeld, Bruder e na perspectiva da mudança e jogo de quadros de Douady. Os resultados mostraram que os estudantes apresentaram diferentes heurísticas, ligadas a diferentes quadros, para resolverem o mesmo problema. As heurísticas apresentadas nas soluções evidenciaram que o contexto do problema não causou dificuldades de interpretação e não interferiu na mobilização de estratégias, mas a natureza dos problemas foi o que causou mais dificuldades ao pensar matemático dos estudantes.
Palavras - chave: IDEB. Ensino Médio. Heurística. Mudanças de Quadros.
AbstractIn this article, we bring an experience report that aims to analyze the problem-solving heuristics of high school 1st grade students. We investigated the heuristics from the records and manifestations of the participants, seeking to verify whether the difficulties of the students to solve problems of large-scale evaluations, whether due to the nature or context of the problems. The problems proposed in the intervention involved algebraic concepts and area and perimeter calculation, with different nature and context, and were solved by a voluntary group of students. To analyze the students' answers, we sought support in the theoretical assumptions of the problem-solving heuristic of Schoenfeld, Bruder and from the perspective of the change and play of Douady's frames to analyze the students' responses. The results showed that the students presented different heuristics, linked to different pictures, to solve the same problem. The heuristics presented in the solutions showed that the context of the problem did not cause difficulties in interpretation and did not interfere in the mobilization of strategies, but the nature of the problems was what caused the most difficulties in the students’ mathematical thinking.
Keywords: IDEB. High School. Heuristics. Frame Change.
Reflexões Sobre a Apropriação das Tecnologias Digitais no Ensino de Matemática: uma Proposta a Partir de uma Revisão Teórica
Authors: Gonzales Kátia Guerchi , Silva Katia Alexandra de Godoi , Lopes Júnior Oswaldo da Silva
Published: March 2022

ResumoEste trabalho tem por objetivo apresentar uma revisão teórica do conceito de apropriação tecnológica por professores a partir das ideias de Borges (2009) e Borges e Valente (2018) e discutir a possibilidade do trabalho com esse referencial teórico no contexto da Educação Matemática. Trata-se de uma pesquisa qualitativa, conforme Severino (2017) que a partir de um levantamento bibliográfico, de acordo com Galvão (2011), apresenta discussões analíticas que se baseiam nas fases que as tecnologias educacionais foram inseridas na sala de aula de matemática e, nos programas e projetos no Brasil com a finalidade de incorporar essas as tecnologias no contexto escolar. Os resultados reforçam a potencialidade do conceito de apropriação em pesquisas que visam discutir a formação de professores de Matemática. Por isso, apresentamos uma proposta que permite a partir das experiências e relatos de professores de Matemática tecer a compreensão sobre as concepções em relação a inserção, integração e apropriação da tecnologia no trabalho docente dentro da disciplina de Matemática.
Palavras-chave: Tecnologia Educacional. Educação Matemática. Licenciatura em Matemática. Políticas Públicas.
Abstract: This paper aims to present a theoretical review of the concept of technological appropriation by teachers from the ideas of Borges and Valente (2018) and discuss the possibility of working with this theoretical framework in the context of Mathematics Education. It is a qualitative research, according to Severino (2017) which, based on a bibliographic survey, according to Galvão (2011), presents analytical discussions that are based on the phases that educational technology were inserted in the mathematics classroom and, in programs and projects in Brazil with the purpose of incorporating technologies in the school context. The results reinforce the potential of the concept of appropriation in research that aims to discuss the formation of mathematics teachers. For this reason, we present a proposal that allows, based on the experiences and reports of Mathematics teachers, to weave an understanding of the conceptions in relation to the insertion, integration and appropriation of technology in teaching work within the discipline of Mathematics.
Keywords: Educational Technology. Mathematics Education. Degree in Mathematics. Public Policy.
Executive Function evaluation in children with learning disabilities through a tablet assessment battery
Authors: Pujals María , Fonseca Liliana Estela
Published: March 2022

Executive functions are a set of psychological processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of certain goals. These skills are necessary to guide learning of new information. Core executive function (CEF) are inhibitory control, working memory and cognitive flexibility. They regulate and control other skills and behaviors, and also have influence on more basic skills such as attention, memory systems, and praxis. Executive functions allow setting goals and carrying them out through planning and monitoring, keeping inhibited thoughts, behaviors and emotions that interfere.

This research consists of determining neuropsychological EF profiles in different clinical populations evaluated with tablet-based test. Two batteries developed by CEDETI UC were applied: Yellow Red and TENI (Infant Neuropsychological Assessment Test). The sample consists of 175 argentine children, between 7 and 12 years old, divided in two groups, clinical and control. The obtained scores show the importance of distinguishing profiles between these three CEF within the clinical population comparing with a typical developing group. The overall index obtained differentiates the groups best. Children with dyscalculia, autistic spectrum disorder and borderline intellectual disability obtain significantly lower scores having greater difficulties in EF.
Morphological and immunogistochemical characteristics of myocardial damage in miastenia
Authors: Todorov S. S. , Deribas V. J. , Kazmin A. S. , Todorov (jr) S. S.
Published: March 2022

The article presents a rare clinical case of a 45-year-old patient with generalized myasthenia with damages to the muscular apparatus of the extremities and the heart. A special feature of the case was myocardial damage evident as alterative-productive interstitial myocarditis with a peculiar immune phenotype of cell infiltrate, Cd3+, Cd4+, Cd8–, Cd68+. Furthermore, Cd68-expressing cells were presented by large macrophages with cytoplasmic granulation, which surrounded damaged cardiomyocytes. Around sites of cardiomyocyte alteration there were manifestations of neoangiogenesis with signs of Cd34 protein expression in thin-wall, capillary type blood vessels. These morphological and immunohistochemical changes in the myocardium supplement the concept of myasthenia morphogenesis.
Diagnosis and treatment of apical hypertrophic cardiomyopathy of the left ventricle
Authors: Skopetckaya S. A. , Leonteva T. V. , Musurivskaya T. V. , Serebryannikova O. S.
Published: March 2022

This article presents a case of diagnosis and treatment of a rare form of left ventricular (LV) hypertrophic cardiomyopathy (HCMP), asymmetric topical HCMP without obstruction of the LV outflow tract, and raises the issue of diagnosis and treatment of rare forms of this disease. In the Federal Center for Cardiovascular Surgery in 2019–2020, 5 cases of asymmetric hypertrophic apical cardiomyopathy were observed and documented with echocardiography (EchoCG), cardiac magnetic resonance imaging (MRI), and Holter ECG monitoring. A 60-year-old female patient underwent a comprehensive evaluation, including physical examination, EchoCG, MRI, Holter ECG monitoring, and coronary angiography. Apical HCMP was detected. The clinical picture was explainable from the perspective of functional and structural alterations in the LV myocardium, where full obstruction of the cardiac apex develops during systole. The small LV cavity is unable to provide effective hemodynamics. Changed small coronary arteries also contribute to this disorder, which, in results, affects myocardial oxygen supply. The administered therapy included antiplatelets, beta-blockers, angiotensin II receptor blockers, diuretics, and ranolazine. The effect of therapy was assessed as positive. Risk of sudden death, according to European Guidelines, 2014 was 0.86 %.
Characteristic of cardiovascular status and intracardiac hemodynamics in patients with multiple myeloma before the start of antitumor therapy
Authors: Kardanova S. A. , Ilgisonis I. S. , Ershov V. I. , Privalova E. V. , Belenkov Yu. N.
Published: March 2022

Aim: assessment of risk factors, cardiovascular status and intracardiac hemodynamics in patients with multiple myeloma before the start of specific antitumor therapy.

 

Materials and methods: The study included 2 equal groups of patients: the first group – 25 patients with a newly diagnosed diagnosis of multiple myeloma (MM), the comparison group – 25 patients with proven cardiovascular diseases (CVD) (hypertension (HD) and coronary heart disease (CHD)). All patients included in the study underwent standard laboratory diagnostics, instrumental research methods (ECG, Echo-KG, 24-hour Holter monitoring); proven CVD risk factors were also evaluated.

 

Results: When comparing the two groups, it was reliably shown that the state of CVD in patients with MM is comparable to that in patients with proven CVD. In patients from the main group, were revealed significant positive correlations of average strength between indicators of systemic inflammation, the lipid spectrum and intracardiac hemodynamics: between the levels of CRP and triglycerides (r=0,415, p<0,05); between the values of CRP and LDL (r=0,345, p=0,09); CRP and LA volume (r=0,434, p<0,05); CRP and final diastolic volume (r=0,30, p<0,05). At the beginning, a high risk of developing CV- events in patients with MM may be due to cardiac remodeling associated with the activity of systemic inflammation.

Conclusion: in view the use of potentially cardiovasculartoxicity drugs for the treatment of multiple myeloma, the assessment of the CV status and consultation with a cardiologist/cardiologist with the selection of the necessary therapy should be obligatory step before starting specific treatment.
Effect of trimetazidine in experimental animals with coronary heart disease or and in combination with diabetes mellitus
Authors: Preethi A Suma , Kumar C Uthira , Reddy Y V Ramakrishna , Kumar K Kalyan , Rao B Nageshwar
Published: March 2022

The epidemic of cardiovascular disease especially coronary heart disease (CHD) is emerging in rural India and accelerating in urban India. Coronary heart disease is the leading cause of death in India; diabetes accounts for a significant burden of CHD events. Trimetazidine (TMZ) is a piperazine derivative with anti-ischaemic properties. It is the first in a new class of metabolic agent, available for clinical use.

: To determine the effect of TMZ on blood parameters in normal, hyperlipidemic, diabetic and Streptozotocin induced diabetic hyperlipidemic rats.

Adult male albino rats of Wistar strain, weighing approximately 150 to 180 g, were used in the present study. After various treatments, blood was collected from the rats by sinocular puncture for the blood parameters like Fasting blood glucose, urine sugar, HbA1c and Haemoglobin with standard protocols.

The levels of blood glucose, HbA1c and urine sugar were found to be elevated in the entire diseased control group than normal control.

TMZ has the potential effect against the STZ induced syndromes with an optimum dose of 40 mg/kg in rats.
A study of microalbuminuria in patients with type 2 diabetes mellitus, visiting tertiary care center Sangli
Authors: Belwalkar G J , Jagtap P E , Mane Vinayak , Shilwant Neha , Nagane N S , Dhonde Sushama
Published: March 2022

Diabetic nephropathy is accompanied with significant micro vascular risk and is the leading cause of kidney disease. Hence there is an immense need to detect early for better quality of the care of affected patients and treat effectively those at high risk of diabetic kidney disease. Our study was aimed to assess the levels of microalbuminuria, glycated hemoglobin, urinary creatinine, urinary albumin to creatinine ratio (ACR) along with blood urea and serum creatinine in patients with type 2 DM, and to observe the incidence of microalbuminuria at tertiary care center; and correlate the presence of microalbuminuria to the duration of DM as well as with ACR.

: Estimation of Blood sugar, Blood Urea, Serum Creatinine, Glycosylated hemoglobin (HbA1c), Urinary micro albumin and creatinine was done. Values of urinary creatinine, microalbumin, urinary albumin to creatinine ratio (ACR) showed highly significant (p<0.000) difference between the two age groups a) below 60 years and b) above 60 years of the age. Highly significant difference (p<0.000) was found among the results of the three groups based on duration of diabetes. We found microalbuminuria was more predominant in patients having age more than 60 years as well as in patients having more than 10 years of duration of DM.

Routine screening for microalbuminuria in type 2 diabetic patients will certainly helpful for early detection of renal damage and thus to minimize the burden of diabetic complications due to renal involvement. Hence addition of microalbuminuria along with diabetic profile for medical checkup will help to assess microalbuminuria at frequent intervals.
Assessment of awareness level of pregnant women about vitamin D and its relation to pregnancy at a tertiary care centre
Authors: Kumari Usha , Kumari Rekha , Sinha Archana , Sharma Raj Kishor
Published: March 2022

Vitamin D deficiency (VDD) during pregnancy has been associated with multiple adverse outcomes of pregnancy like preeclampsia, gestational diabetes mellitus, low birth weight, preterm delivery, and cesarean section. Vitamin D deficiency (VDD) is higher in females especially during pregnancy, breast feeding & child bearing age. Studies have reported VDD during pregnancy ranging from 14% to more than ninety percent in our country. Several factors like age, nutrition, socio-cultural practices, geographical conditions etc. contribute to vitamin D deficiency. The lack of awareness about vitamin D is one of the biggest factors.

To assess the level of awareness about Vitamin D and its relation to pregnancy among pregnant ladies.

This cross-sectional study was conducted on 280 pregnant females using a self administered questionnaire. The awareness level of participants was labeled as Poor, Average & Good according to the marks obtained. Statistical analysis was done using Excel Analysis Toolpak.

The age of participants ranged from 19 years to 34 years (mean 24.85 ± 2.98). Majority of the participants were in the age group 20-25 years (66.79%). Most of the participants were living in rural areas (77.5%) while 22.5% belonged to urban areas. The mean score of all the participants was 6.25 with SD 2.29. Educational status showed a linear relationship with the awareness level.

There is a lack of awareness about vitamin D. Awareness campaigns will reduce vit-D deficiency and improve pregnancy outcomes.
A Dialogue with Nature Through Biophilic Design: Focus on the Façade Wall in the Architecture of Laurie Baker’s Houses
Authors: Sadanand Anjali , Chander Sheeba , Devadas Monsingh
Published: March 2022

Man connects with nature and is inspired by nature. Architects based on this interaction with nature create an architectural language of forms, spatial volumes, shapes, and materials, which develop from their own individual philosophy and their perception of the connection between nature and architecture which can be disseminated into components. A dialogue with nature also includes the impact of nature on design as experience. The paper will suggest that biophilic design is an outcome from this interaction and can be illustrated in the interface between the built environment and nature at various levels seen in the interplay of elements, creation of spaces and in the morphology of shapes, forms, materials, texture and in patterns. The objective of this paper is to study the architectural language of Laurie Baker with focus on the role played by the façade wall in creating multiple experiences which can be assimilated into patterns. The façade wall of a sample of houses built in 1990’s in Trivandrum will be analysed to illustrate this connection. A set of patterns based on the analysis will be proposed.
Rzecz o kształtowaniu tożsamości zawodowej nauczyciela
Authors: De Tchorzewki Andrzej M.
Published: March 2022

Podstawowym celem naukowym artykułu jest zwrócenie uwagi na jedno z ważnych zagadnień, które mieści się w obszarze pedeutologii. Dotyczy ono treści i zakresu nauczycielskiej tożsamości zawodowej, analizy jej źródeł i podstaw, a także atrybutów. Problemy wynikające z tych zagadnień zostały ujęte w strategię poszukiwań odpowiedzi na pytania o strukturę i dynamikę ich kształtowania się. Proces wywodu sprowadza się do odpowiedzi na pytanie o znaczenie nauczycielskiego etosu i generacji praw podmiotowych będących świadectwem zawodowej tożsamości. Ponadto wskazano w nim na rolę i istotę procesu dochodzenia nauczycieli do zawodowej tożsamości w czasach chaosu aksjonormatywnego. Przeprowadzona analiza zmierzała do opisu poznawczego, wyjaśnienia wraz z interpretacją głównego przedmiotu podjętego zagadnienia oraz aplikacji w postaci pytań otwartych skierowanych w zakończeniu do czytelników.
Solving ‘the Uniform Issue’: Gender and Professional Identity in the Swedish Military
Authors: Strand Sanna , Persson Alma , Sundevall Fia
Published: March 2022

This article contributes empirical knowledge about the shifting ways in which the Swedish Armed Forces (SAF) has articulated and addressed ‘the uniform issue’, that is, matters concerning servicewomen’s access to adequate uniforms and other equipment, since the 1980s. Drawing on analytical tools employed within post-structural policy analysis, we demonstrate how ‘the uniform issue’ has gone from being articulated as a problem for servicewomen, and to be solved by servicewomen, to a problem for the SAF in its pursuit to become an attractive employer and a legitimate public authority. By shedding light on how ‘the uniform issue’ has been problematized in shifting ways since Swedish women first were allowed to serve in all military positions, this article also contributes important insights into broader scholarly debates about workplace discrimination, gender equality, and gendered occupational identities in military work.
Formation of a Roman Public Opinion by Octavian (from Ilyrian Campaign to Actium)
Authors: AKHIEV S.N.
Published: March 2022

The article discusses the means and methods that Octavian used to form the public opinion of the Romans in the period 34–32 BC. The author notes their diversity and intensive use in political propaganda, but their effectiveness should not be exaggerated. Only patriotic slogans made Octavian the true leader of the Roman Republic. Octavian`s political talent was that he managed to capture and use Romans moods in his interests.
An Assemblage of the Mid-6th Century BC Well from the Berezan Excavations of 1963/1964
Authors: MONAKHOV S.Yu. , KUZNETSOVA E.V. , CHISTOV D.E.
Published: March 2022

The article is devoted to the assemblage of finds from the well excavated by the State Hermitage archaeological mission under the direction of K.S. Gorbunova in 1963–1964 on the Berezan island. Transport amphorae are represented by the Samian, Lesbian and Klazomenian production. In addition, fragments of handles belonging to Cypriot basket-handle amphorae appear in the same deposit. The filling of the well contained the significant number of complete and fragmented tableware vessels of the Corinthian, Chian, Attic, North and South Ionian production. The dating of painted pottery fits into the narrow chronological limits of the beginning – early third quarters of the 6th century BC. The deposit of the well is close to the ’border’ deposits and structures precedent to the early stage of the mass construction of stone-and-mudbrick houses in the third quarter of the 6th century BC. Probably, the well is synchronous with the dugouts of the second quarter of that century but it was filled up in the course of the rapid urbanization of the colony in the 540s BC or slightly later.
The Curious Case of Centrality Measures: A Large-Scale Empirical Investigation
Authors: Saqr Mohammed , López-Pernas Sonsoles
Published: March 2022

There has been extensive research using centrality measures in educational settings. One of the most common lines of such research has tested network centrality measures as indicators of success. The increasing interest in centrality measures has been kindled by the proliferation of learning analytics. Previous works have been dominated by single-course case studies that have yielded inconclusive results regarding the consistency and suitability of centrality measures as indicators of academic achievement. Therefore, large-scale studies are needed to overcome the multiple limitations of existing research (limited datasets, selective and reporting bias, as well as limited statistical power). This study aims to empirically test and verify the role of centrality measures as indicators of success in collaborative learning. For this purpose, we attempted to reproduce the most commonly used centrality measures in the literature in all the courses of an institution over five years of education. The study included a large dataset (n=3,277) consisting of 69 course offerings, with similar pedagogical underpinnings, using meta-analysis as a method to pool the results of different courses. Our results show that degree and eigenvector centrality measures can be a consistent indicator of performance in collaborative settings. Betweenness and closeness centralities yielded uncertain predictive intervals and were less likely to replicate. Our results have shown moderate levels of heterogeneity, indicating some diversity of the results comparable to single laboratory replication studies.
Exploring the Utility of Social-Network-Derived Collaborative Opportunity Temperature Readings for Informing Design and Research of Large-Group Immersive Learning Environments
Authors: Mallavarapu Aditi , Lyons Leilah , Uzzo Stephen
Published: March 2022

Large-group (n > 8) co-located collaboration has not been adequately studied because it demands different conceptual framings than those used to study small-group collaboration, while also posing pragmatic constraints on data collection. Working within these pragmatic constraints, we use video data to devise an indicator of the current possibilities for learner collaboration during large-group co-located interactions. We borrow conceptualizations from proxemics and social network analysis to construct collaborative opportunity networks, allowing us to define the concept of collaborative opportunity temperature (COT) readings: a “snapshot” of the current configuration of the different social subgroup structures within a large group, indicating emergent opportunities for collaboration (via talk or shared action) due to proximity. Using a case study of two groups of people (n = 11, n = 12) who interacted with a multi-user museum exhibit, we outline the processes of deriving COT. We show how to quickly detect differences in subgroup configurations that may result from educational interventions and how COT can triangulate with and complement other forms of data (audio transcripts and activity logs) during lengthier analyses. We also outline how COT readings can be used to supply formative feedback on social engagement to learners and be adapted to other learning environments.
Knowledge Transfer in a Two-Mode Network Between Higher Education Teachers and Their Innovative Teaching Projects
Authors: Stasewitsch Elena , Barthauer Luisa , Kauffeld Simone
Published: March 2022

Knowledge transfer (KT) and innovation diffusion are closely related to each other because it is knowledge regarding an innovation that gets adopted. Little research in learning analytics provides insight into KT processes in two-mode networks, especially in the context of educational innovations. It is unclear how such networks are structured and whether funding can create a network structure efficient for KT. We used a case-study approach to analyze a two-mode network of 208 university members (based on archival data) who worked together on 91 innovative teaching projects. Our results show that the two-mode network displays a decentralized structure and more clustering than can be assumed by chance, promoting KT and learning. To gain a deeper understanding of the kind of knowledge that is transferred in the network, we analyzed the effects of different educational innovation elements (e.g., game-based learning) as attributes of higher education teachers. Overall, our results suggest that funding and the creation of project structures in the context of educational innovation is a sustainable way to create KT, and therefore organizational change. Furthermore, the results imply that university practitioners need to implement networking interventions to create more connections between subgroups in teacher-related networks.
The utility of strain elastography in differentiation between healthy thyroid parenchyma and residual/recurrent thyroid parenchyma disorders
Authors: GÜL Yeliz , KILIÇARSLAN Gülhan , ÖZKAN Zeynep , BALABAN Mehtap
Published: March 2022

Objectives: This study is designed to evaluate the utility of strain elastography in the differentiation between healtly thyroid parenchyma and residual/recurrent thyroid parenchyma after partial thyroidectomy.
Methods: Gray-scale ultrasonography (B-mode US) and strain elastography were performed in patients who had undergone partial thyroidectomy due to benign thyroid diseases and volunteers as a control group without any throid disease. The elasticity scores and strain rate values of thyroid parenchyma were obtained in two groups and compared. The strain elastography of the patient and control groups were analyzed with the Pearson Chi-Square test. Strain rates for both groups were compared with the Manny-Whitney U test. Ethical approval and permissions were obtained from legally authorized representatives and patients.
Results: There were 94 cases in total, 47 cases (4 male, 43 female; mean age: 51 ± 12.9 years, ranging between 25-79) in the patient group and 47 cases (11 male, 36 female; mean age: 36.8 ± 11.5 years, ranging between 19-71) in the control group. The strain rate of the right (2.22 ± 1.9) and left thyroid lobe (1.9 ± 1.9) were significantly higher than control group (1.05 ± 0.6 and 0.8 ± 0.5, respectively; p = 0.002 and p = 0.043).
Conclusions: The elasticity of thyroid parenchyma after partial thyroidectomy differs from healthy thyroid tissue, which may be helpful in differentiation between residual parenchymal changes in thyroid from malignant lesions with strain elastography.