bluuebunny/crossref_metadata_2025 huggingface dataset:
Full-Mouth Screw-Retained Implant-Supported Rehabilitation with Multiunit Abutments Using Virtual Guided Surgery and Digital Prosthetics Protocol
Authors: Ashurko Igor , Trofimov Artem , Tarasenko Svetlana , Mekhtieva Sabina
Published: September 2020

Total rehabilitation is one of the most sophisticated kinds of dental implant-supported prosthetics. The usage of multiunit abutment system allows the clinician an accurate and passive fitting of screw-retained full-arch construction. In addition, it retains a condition of soft and bone tissues around prosthetic construction. The aim of this case is to demonstrate a modern approach in planning and realisation of full-mouth screw-retained dental implant prosthetics. A 59-year-old patient had an extraction of all failed teeth on upper and lower jaws with immediate 16 implant placement (8 implants on maxilla and 8 implants on mandible) using surgical template. Multiunit abutments were installed intraoperatively. Temporary constructions were fixed immediately after surgery. After 3 months of dental impressions, plaster models and their scan were prepared to make final screw-retained zirconium dioxide constructions. Reevaluation of functional and aesthetic result of the treatment was made after 12 months.
A Hybrid Approach Calculating Lateral Spreading Induced by Seismic Liquefaction
Authors: Yang Yanxin , Liu Jianguo , Ma Jianlin , Wang Qinke
Published: September 2020

Liquefaction-induced lateral spreading has caused severe damages to the infrastructures. To predict the liquefaction-induced lateral spreading, a hybrid approach was proposed based on the Newmark sliding-block model. One-dimensional effective stress analysis based on the borehole investigation of the site was conducted to obtain the triggering time of liquefaction and acceleration time history. Shear wave velocity of the liquefiable soil was used to estimate the residual shear strength of liquefiable soil. The limit equilibrium analysis was conducted to determine the yield acceleration corresponding with the residual shear strength of liquefied soil. The liquefaction-induced lateral spreading was calculated based on the Newmark sliding-block model. A case study based on Wildlife Site Array during the 1987 Superstition Hills earthquake was conducted to evaluate the performance of the hybrid approach. The results showed that the hybrid approach was capable of predicting liquefaction-induced lateral spreading and the calculated lateral spreading was 1.5 times the observed displacement in terms of Wildlife Site Array. Numerical simulations with two other constitutive models of liquefiable sand were conducted in terms of effective stress analyses to reproduce the change of lateral spreading and excess pore water ratio over the dynamic time of Wildlife Site Array. Results of numerical simulations indicated that the lateral spreading varied with the triggering time of liquefaction when different constitutive models were used. The simulations using PM4sand and UBC3D-PLM constitutive models predicted 5.2 times and 4 times the observed lateral spreading, respectively. To obtain the site response, the motions recorded at and below the ground surface were analyzed using the Hilbert–Huang transform. The low-frequency content of the motion below the ground surface was amplified at the ground surface, and the liquefaction effect resulted in a shift of the frequency content. By comparing the response spectra of the entire ground surface motion and the ground surface motion from the beginning to the triggering time of liquefaction, the liquefaction effect at the site was confirmed.
MicroRNA‐Related Prognosis Biomarkers from High‐Throughput Sequencing Data of Colorectal Cancer
Authors: Xing Xiao-Liang , Yao Zhi-Yong , Zhang Ti , Zhu Ning , Liu Yuan-Wu , Peng Jing
Published: September 2020

Background. Colorectal cancer (CRC) is the third most common cancer in the world, and most of them are adenocarcinomas. CRC could be classified as colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) according to the original tumorigenesis position. Increasing evidences indicated that microRNAs (miRNAs) play an important role in the occurrence of multiple tumors. Methods. In this study, we firstly downloaded miRNA (COAD, 8 controls vs. 455 tumors; READ, 3 controls vs. 161 tumors) and mRNA (COAD, 41 controls vs. 478 tumors; READ, 10 controls vs. 166 tumors) data from The Cancer Genome Atlas (TCGA) database and then used DESeq2, RegParallel, miRDB, TargetScanHuman 7.2, DAVID 6.8, STRING, and Cytoscape software to identify the potential prognosis biomarkers. Results. We identified 175 differential expression miRNAs (DEMs) and 3747 differential expression genes (DEGs) in COAD and 184 DEMs and 3928 DEGs in READ. And then, we obtained 21 (13 in COAD and 8 in READ) DEMs associated with the survival rates, which correlated with 440 (217 in COAD and 223 in READ) overlapping DEGs. Through survival analysis for those overlapping DEGs, we found 11 (8 in COAD and 3 in READ) overlapping DGEs associated with survival rates of patients, which were correlated with 9 (7 in COAD and 2 in READ) DEMs significantly. Conclusion. In this study, we found several candidate prognostic biomarkers which have been identified in various cancers and also found several new prognosis biomarkers of COAD and READ. In conclusion, this analysis based on theoretical knowledge and clinical outcomes we have done needs further confirmation by more researches.
Fragility‐Based Improvement of System Seismic Performance for Long‐Span Suspension Bridges
Authors: Lu Guanya , Wang Kehai , Qiu Wenhua
Published: September 2020

In this study, a procedure is developed to evaluate and improve the seismic performance of long‐span suspension bridges based on the performance objectives under the fragility function framework. A common type of suspension bridge in China was utilized in the proposed procedure, considering its approach structures according to earthquake damage experience and fortification criteria. Component‐level fragility curves were derived by probabilistic seismic demand models (PSDMs) using a set of nonlinear time‐history analyses that incorporated the related uncertainties such as earthquake motions and structural properties. In addition, one step that was covered was to pinpoint the capacity limit states of critical components including bearings, pylons, and columns. The stepwise improved seismic designs were proposed in terms of the component fragility results of the as‐built design. Results of the comparison of improved designs showed that the retrofit measure of the suspension span should be selected based on two attributes, i.e., displacement and force, and the restraint system of the approach bridges was a key factor affecting the reasonable damage sequence. Necessarily, from the comparison of different system vulnerability models, the mean values of earthquake intensity of system‐level fragility function developed by the composite damage state indices were used to assess the overall seismic performance of the suspension bridge. The results showed that compared to the absolutely serial and serial‐parallel assumptions, the defined composite damage indices incorporating the thought of component classification and structural relative importance between the main bridge and approach structures were necessary and were able to derive a good indicator of seismic performance assessment, hence validating the point that the different damage states were dominated by the seismic demands of different structures for the retrofitted bridges.
Deep Vein Thrombosis and Pulmonary Embolism in the Setting of Mycoplasma Infection
Authors: Saleem Sandal , Berman Brian
Published: September 2020

Thirteen-year-old female twins presented one week apart with documented Mycoplasma pneumoniae respiratory infection. Each developed venous thrombosis and pulmonary emboli in association with transient self-limited para-infectious anti-phospholipid antibodies. Comprehensive evaluation revealed no identifiable genetic prothrombotic variables. Both children recovered after receiving antibiotics and anticoagulation therapy. Thrombotic complications associated with Mycoplasma pneumoniae infections are rare, particularly in children; the occurrence of this complication in identical twins has not been previously reported.
Influence of Key Strata on the Gas Downward Leakage Law in Dual-System of Coal Seam
Authors: Du Feng , Jiao Kun , Ma Zhanyuan
Published: September 2020

In Datong mining area, CO and other harmful gases were discharged from the gob in the Jurassic overburden strata to the panel of Carboniferous coal seam. To this end, panel 8309 of Tongxin coal mine in Datong mining area was taken as the engineering background; the change law of CO concentration in the upper corner of the panel and the law of mining pressure were studied through field measurement, and the influence of periodic movement of key strata on the downward leakage law of harmful gases was analyzed. In this paper, the fracture law of the key strata and fracture development characteristics of overburden strata were further studied by the similar simulation test, and the influence of the periodic movement of the key strata on the pathway formation of gas downward leakage was analyzed. The results show that the main cause of harmful gas downward leakage in the Jurassic gob is through the fracture produced by the fracture of the higher key strata. If the higher key strata fractures in the coal mining in the Carboniferous system, through fracture connecting the Jurassic gob above the open-off cut and the upper part of the panel are formed, and effective pathways for gas downward leakage are generated. The fracture and rotation of the higher key strata are accompanied by the formation and disappearance of the effective pathway for gas downward leakage above the panel. Then the periodic change of harmful gas discharging to the panel is caused and consistent with the law of mining pressure.
Effects of Glottalisation, Preceding Vowel Duration, and Coda Closure Duration on the Perception of Coda Stop Voicing
Authors: Penney Joshua , Cox Felicity , Szakay Anita
Published: September 2020

English has multiple potential acoustic cues to coda stop voicing, including the duration of the preceding vowel, the coda closure duration, and, in some varieties, glottalisation. Glottalisation associated with coda stops appears to be a recent change to Australian English (AusE) with younger speakers using glottalisation more than older speakers in production. Here we report on a study designed to examine AusE-speaking listeners’ perception of cues to coda stop voicing. Listeners were presented with audio stimuli in which preceding vowel duration, coda closure duration, and the relative proportions of the rhyme that these occupy were manipulated and co-varied with the presence or absence of glottalisation. The results show that listeners used preceding vowel duration to cue coda stop voicing, and that coda closure duration was a weaker cue to voicing when not varied in conjunction with preceding vowel duration. In addition, glottalisation facilitated increased perception of coda voicelessness, even when paired with very long preceding vowels, which otherwise signal coda voicing. Although age-related differences in production have previously been reported, we found that both older and younger listeners used glottalisation similarly in perception. These results may provide support for a sound change led by a shift in perception.
Manifiesto por una economía con sentido moral y en la persistencia de la búsqueda de justicia social
Authors: Garcia Pascual , Rodriguez-Serrano Alfredo
Published: September 2020

El sistema económico imperante lejos de lograr reducir las brechas sociales, las ha hecho más amplias, desde la consolidación del sistema de producción capitalista, gran parte de la humanidad se ha visto obligada a vivir en condiciones de precariedad, pobreza e injusticia social, llegando al extremo de amenazar su propia vida. Las grandes multinacionales y gobiernos que sustentan sus acciones en beneficio propio con el apoyo de un cuantioso número de economistas ortodoxos quienes han creado un sistema económico y una economía perversa, cuya función es servir a la clase dominante perpetuando su poder mediante el uso de la crematística en lugar de la Etica y la economía, la creación de modelos matemáticos, y la idea de que crecimiento y desarrollo son incluyentes; se ha olvidado los orígenes históricos, éticofilosóficos de la ciencia económica, que abogaban por una justicia social y disminución de las desigualdades económico-sociales.

El presente texto, realiza una reflexión critica histórica de la economía y su tergiversación hacia la crematística y sus enunciados perfomativos en sus modelizaciones matemáticas.
Regulation of IL (Interleukin)-33 Production in Endothelial Cells via Kinase Activation and Fas/CD95 Upregulation
Authors: Duez Catherine , Gross Barbara , Marquillies Philippe , Ledroit Valérie , Ryffel Bernhard , Glineur Corine
Published: September 2020

Objective:

The occurrence of new blood vessel formation in the lungs of asthmatic patients suggests a critical role for airway endothelial cells (ECs) in the disease. IL-33 (Interleukin-33)—a cytokine abundantly expressed in human lung ECs—recently emerged as a key factor in the development of allergic diseases, including asthma. In the present study, we evaluated whether mouse and human ECs exposed to the common
Dermatophagoides farinae
allergen produce IL-33 and characterized the activated signaling pathways.

Approach and Results:

Mouse primary lung ECs were exposed in vitro to
D farinae
extract or rmIL-33 (recombinant murine IL-33). Both
D farinae
and rmIL-33 induced
Il-33
transcription without increasing the IL-33 production and upregulated the expression of its receptor, as well as genes involved in angiogenesis and the regulation of immune responses. In particular,
D farinae
and rmIL-33 upregulated
Fas/Cd95
transcript level, yet without promoting apoptosis. Inhibition of caspases involved in the Fas signaling pathway, increased IL-33 protein level in ECs, suggesting that Fas may decrease IL-33 level through caspase-8-dependent mechanisms. Our data also showed that the NF-κB (nuclear factor-κB), PI3K/Akt, and Wnt/β-catenin pathways regulate
Il-33
transcription in both mouse and human primary ECs.

Conclusions:

Herein, we described a new mechanism involved in the control of IL-33 production in lung ECs exposed to allergens.
Herpetological higher taxa nomina 1. Introduction and methodology

Authors: DUBOIS ALAIN , FRÉTEY THIERRY
Published: September 2020

This work introduces a series of papers devoted to the ascertainment of the valid nomina, under the revised Duplostensional Nomenclatural System (DONS-2), of the highest taxa (from the rank order to the rank class) of recent amphibians and ‘reptiles’. The main general features of the DONS approach to class-series nomenclature (above the rank superfamily) are explained in detail, the DONS-2 procedure for ascertaining the availability, allocation, validity and correctness of class-series nomina is described, and a Glossary of all the technical nomenclatural terms used in this work is provided.
The nomenclatural status of new nematode nomina proposed in 1993 in the doctoral thesis of Christian Bussau, entitled Taxonomische und ökologische Untersuchungen an Nematoden des Peru-Beckens (Nematoda)

Authors: HOLOVACHOV OLEKSANDR
Published: September 2020

In his doctoral thesis, Christian Bussau published 110 new nematode nomina, including 97 nomina of new species, 11 of new genera and two of new subfamilies. The nomenclatural availability of these nomina has not been generally accepted and is evaluated here. It is determined that the doctoral thesis published by Bussau (1993) satisfies the criteria of publication outlined in Article 8 of the Code, and that all nomenclatural acts published in it satisfy the criteria of availability outlined in Articles 11 and 13 of the Code. The correct authority for all nomina first published in Bussau (1993) is ‘Bussau, 1993’, and not ‘Bussau, 1995’ or ‘Bussau & Vopel, 1999’. All nomenclatural acts published in Bussau (1995) and Bussau & Vopel (1999) are junior objective synonyms of acts published in Bussau (1993), except for Bathynox Bussau & Vopel, 1999. Nox Bussau, 1993 is a junior homonym of Nox Nalbant, 1986, and was provided the available new replacement nomen Bathynox Bussau & Vopel, 1999. The correct authority of Bathynox clavata is ‘(Bussau, 1993)’.
Comments on the nomenclatural status and validity of several family-series nomina in Actiniaria (Cnidaria, Anthozoa)

Authors: SANAMYAN KAREN , SANAMYAN NADYA
Published: September 2020

The nomenclatural status of several family-series nomina is discussed. In a recently published catalogue of sea anemones, a large family Sagartiidae was treated as invalid and no solution was provided, all sagartiid genera being listed as incertae sedis. In the present work, a solution concerning this family is proposed, and in consequence the nomen Sagartiidae is considered valid. The valid generic nomen for the species previously assigned to Sagartia is Cylista, and a  type species is designated for this genus. The nomen Minyadidae is invalid. The nomina Oractiidae and Hormathiidae are valid. The latter is younger than Chondractiniidae but is deemed to be its senior synonym. The nomen Adamsidae is a senior synonym of Hormathiidae but is rejected in the present work as a nomen oblitum. The nomen Halcuriidae is valid. It is younger than Endocoelactinidae but is deemed to be its senior synonym. The nomen Flosmarinidae is senior synonym of Isophelliidae and must be used as valid instead of the currently accepted Isophelliidae.
Additions to the Estonian fauna of mycophagous Cecidomyiidae (Diptera), with a description of Unicornella estonensis gen. et sp. nov.
Authors: SIKORA TOMÁŠ , JASCHHOF MATHIAS , KURINA OLAVI
Published: September 2020

Mycophagous gall midges from two Malaise trapping campaigns in Estonia were subjected to a morpho-taxonomic study, with the aim of identifying previously unrecorded species. Fifty-four species are shown for the first time to occur in Estonia, specifically 1 Lestremiinae, 21 Micromyinae, 5 Winnertziinae, and 27 Porricondylinae. This raises the number of mycophagous cecidomyiids known from Estonia to 152, which is about one fourth of the total estimated for the national fauna. One of the Porricondylinae turned out to be new to science and is described as Unicornella estonensis Jaschhof & Sikora. Unicornella, a new genus of the tribe Porricondylini, is characterized by that males have a single gonocoxal process, as opposed to two or no processes found in other Porricondylini.
1. Surrogate Skin
Authors: Scarville Keisha
Published: September 2020

Artist Keisha Scarville spent her childhood raised in Brooklyn where her parents, along with so many other Guyanese immigrants, migrated and settled after leaving Guyana in the 1960s. In her photography essay, ‘Surrogate Skin: Portrait of Mother (Land),’ Scarville reflects on her portraiture series, ‘Mama’s Clothes,’ an homage to her late mother. In the portraits, Scarville embodies her mother’s dresses to evoke her connection to Guyana. In both her prose and portraits, Scarville grounds herself in her mother's place of birth of Buxton (Guyana) and her neighborhood of Flatbush (US). The lush, organic landscapes in these images, shifting between Guyana and the US, hold emotional and geographical significance: they capture the artist and her mother’s dance between transient spaces. Grappling with ‘a sense of displacement and an internal fracturing’ after her mother’s passing, Scarville looked to her ‘mama’s clothes’ of bright colors, strong prints, and long flowing fabrics for meaning. She drapes and layers her body in her mother’s clothing as well as fashions masks and veils to cover her face, which is always obscured. In merging her body with her mother’s clothes, Scarville marries both time and space—two generations, two homelands, and the complexities in between.
3. Electric Dreams
Authors: Hopkinson Natalie , Hopkinson Serena
Published: September 2020

In a series of letters that read as intimate journal entries, letters that could easily belong to familiar collections like ‘Letters to My Younger Self,’ letters that unveil deep untold secrets and desires, mother and daughter Serena Hopkinson and Natalie Hopkinson reveal the great love and admiration that abides at the core of their relationship. It is a mother-daughter bond that has seen several migrations across three countries: Guyana, Canada, the US, and many returns and reunions in between. Guyanese-born Serena Hopkinson migrated to Toronto in 1970 as a young bride who would soon embark on building a family of her own while navigating the terrain of being an immigrant in Canada and later the United States. The Hopkinson family life was one in constant transition, defined as being ‘on the move.’ The letters the Hopkinson women write to each other in ‘Electric Dreams’ are symbolic postmarks of the places they have borne witness to, survived, and thrived: Pomeroon River, Guyana; Edmonton, Canada; and Florida and Washington, DC, United States. Like so many immigrant families who have left Guyana, a series of arrivals and departures in search of ‘a better life,’ took its toll on Serena’s marriage and on Natalie, her Canadian-born daughter’s identity and selfhood. What this duo brings to light is that despite the emotional toll migration takes on families, their relationship has been a constant driving force. It continues, to this day, to sustain, inspire, and buoy them as they chart new paths and adventures in their roles as women, daughters, wives, mothers, grandmothers, teachers and life-long learners.
8. So I Pick Up Me New-World-Self
Authors: Nichols Grace
Published: September 2020

The space between departure and arrival is a terribly fragile one. As Grace Nichols pinpoints her first flight—her precise moment of leaving Guyana—she unravels how that singular moment of departure changed the course of her life forever. Her essay, ‘So I Pick Up Me New-World-Self,’ punctuated with poems ignited by her early years after her arrival in England, details the days when she embarked on the work of inventing the woman and writer she hoped to become. Within both her poems and her reflections, is a similar refrain for women who migrate: our acts of leaving are rarely, if ever, about desire. Instead, they are acts of necessity. Nichols likens her departure to a kind of rupturing, a severing. And then she is confronted with the shock of arrival and the stain of unbelonging thrust on her. As a Guyanese-born woman who has now lived in the United Kingdom longer than she has lived in her homeland, Nichols charts how we leave our old-world self to fashion, in her words, our ‘new-world self.’
11. A Trace | Evidence of Time Past
Authors: Brewster Sandra
Published: September 2020

In ‘A Trace | Evidence of Time Past,’ Canadian-born artist Sandra Brewster elevates the voices of the matriarchs in her family. Brewster’s family history of migration from Guyana beginning in the 1960s—a decade in which the country saw a tremendous exodus to Canada—parallels the emergence of Toronto as a prominent node in the Caribbean diaspora and one of the largest and oldest Guyanese populations outside of Guyana. As a daughter of immigrant parents, Brewster grew up hearing her family’s stories of life in Georgetown—stories that simultaneously gave her a connection to Guyana as well as left her with questions. In her art essay, she generously mines those questions and offers us the stories, memories, and language of her grandmother, mother, sister, aunts, and cousins whose words simultaneously trace a rupture and chart a chronology: What did it take to leave a beloved Guyana and build a life in an uncertain Canada? As Brewster documents that process, what is revealed is that it takes generations, it takes a whole family, it takes the driving force of women to get to a place of not merely surviving and adapting, but thriving.
14. Keeping Wake
Authors: Mackrandilal Maya
Published: September 2020

To create the body of work ‘Keeping Wake’ featured in her art essay, American-born artist Maya Mackrandilal journeyed to Guyana in 2011. She returned to the rice fields where her Guyanese-born mother grew up, until she too left as a young woman. We find Mackrandilal in the midst of loss and death as rituals and preparations are made for her grandmother’s funeral. Water is a key symbol throughout ‘Keeping Wake.’ Mackrandilal paints vivid scenes that mirror the crossing of the kal pani—Hindi for ‘dark waters’—conjuring the traumatic voyage of Indian indentured laborers from India to British Guiana. We are reminded that the history of the Indian crossing into Guyana is a dark one. Indeed, contributors Suchitra Mattai and Maria del Pilar Kaladeen also poignantly link their migration stories to their Indian family legacies. Between 1838 and 1917, over 500 ship voyages deposited more than a quarter-million men and women from India to British Guiana’s Atlantic coast. They would spend over eight decades toiling on sugar plantations and rice fields. Mackrandilal connects generations of those who ventured into the kal pani two centuries ago with those who embark on symbolic crossings of their own twenty-first-century dark waters. The rupture created by the initial crossing of the kal pani remains pervasive. It now haunts a second wave of migration, this time from Guyana to the United States. As she contemplates the past, questioning why the majority of the indentured laborers never returned to India, Mackrandilal draws comparisons to the distance she and her mother now experience with Guyana and reflects on their absence in their homeland. She ponders an important question for us all in the poignant narration of her 2014 video work, Kal/Pani, ‘Acres of rice farm in a country we rarely visit […] what are we, the generation that exists in the wake of estrangement, to make of the pieces?’
Model Biases in the Simulation of the Springtime North Pacific ENSO Teleconnection
Authors: Chen Ruyan , Simpson Isla R. , Deser Clara , Wang Bin
Published: September 2020

The wintertime ENSO teleconnection over the North Pacific region consists of an intensified (weakened) low pressure center during El Niño (La Niña) events both in observations and in climate models. Here, it is demonstrated that this teleconnection persists too strongly into late winter and spring in the Community Earth System Model (CESM). This discrepancy arises in both fully coupled and atmosphere-only configurations, when observed SSTs are specified, and is shown to be robust when accounting for the sampling uncertainty due to internal variability. Furthermore, a similar problem is found in many other models from piControl simulations of the Coupled Model Intercomparison Project (23 out of 43 in phase 5 and 11 out of 20 in phase 6). The implications of this bias for the simulation of surface climate anomalies over North America are assessed. The overall effect on the ENSO composite field (El Niño minus La Niña) resembles an overly prolonged influence of ENSO into the spring with anomalously high temperatures over Alaska and western Canada, and wet (dry) biases over California (southwest Canada). Further studies are still needed to disentangle the relative roles played by diabatic heating, background flow, and other possible contributions in determining the overly strong springtime ENSO teleconnection intensity over the North Pacific.
Fuzzy Postprocessing to Advance the Quality of Continental Seasonal Hydrological Forecasts for River Basin Management
Authors: Macian-Sorribes Hector , Pechlivanidis Ilias , Crochemore Louise , Pulido-Velazquez Manuel
Published: September 2020

Streamflow forecasting services driven by seasonal meteorological forecasts from dynamic prediction systems deliver valuable information for decision-making in the water sector. Moving beyond the traditional river basin boundaries, large-scale hydrological models enable a coordinated, efficient, and harmonized anticipation and management of water-related risks (droughts, floods). However, the use of forecasts from such models at the river basin scale remains a challenge, depending on how the model reproduces the hydrological features of each particular river basin. Consequently, postprocessing of forecasts is a crucial step to ensure usefulness at the river basin scale. In this paper we present a methodology to postprocess seasonal streamflow forecasts from large-scale hydrological models and advance their quality for local applications. It consists of fuzzy logic systems that bias-adjust seasonal forecasts from a large-scale hydrological model by comparing its modeled streamflows with local observations. The methodology is demonstrated using forecasts from the pan-European hydrological model E-HYPE at the Jucar River basin (Spain). Fuzzy postprocessed forecasts are compared to postprocessed forecasts derived from a quantile mapping approach as a benchmark. Fuzzy postprocessing was able to provide skillful streamflow forecasts for the Jucar River basin, keeping most of the skill of raw E-HYPE forecasts and also outperforming quantile-mapping-based forecasts. The proposed methodology offers an efficient one-to-one mapping between large-scale modeled streamflows and basin-scale observations preserving its temporal dependence structure and can adapt its input set to increase the skill of postprocessed forecasts.
Influence of limiting the actuation strain on the functional fatigue behavior of Ni50.3Ti29.7Hf20 high temperature shape memory alloy
Authors: Tugrul H Onat , Saygili Hasan H , Kockar Benat
Published: September 2020

The cyclic stability and the fatigue life of NiTiHf alloys are very important for their functionality at high temperatures. The previous studies have shown that the increase in Upper Cycle Temperature (UCT) and the magnitude of applied stress decreased the cyclic stability and fatigue life of NiTiHf high temperature shape memory alloys due to plasticity with dislocation formation at high temperature. On the other hand, this study was dedicated to the effect of limited actuation strain against the applied constant stress to the functional fatigue life and the possible damage mechanism such as dislocation and crack formation. Strain limitation led to observe insignificant amount of accumulated irrecoverable strain but significant amount of crack formation such that the reason of the failure of Ni50.3Ti29.7Hf20 (at%) alloy was found to be the crack formation instead of dislocation accumulation.
Fractures are common within 18 months following first-line R-CHOP in older patients with diffuse large B-cell lymphoma
Authors: Booth Stephen , Plaschkes Hannah , Kirkwood Amy A. , Gibb Adam , Horgan Patrick , Higham Claire , Oladipo Joanna M. , Browning Joe , Khan Usman , Tseu Bing , Chen Lucia , Willan John , Wolf Julia , Gunawan Arief , Fields Paul , Ebsworth Tim , Lown Robert , Gordon-Walker Dominic , Shah Nimish , Linton Kim M. , Collins Graham P. , Kothari Jaimal , Hildyard Catherine , Eyre Toby A.
Published: September 2020

Diffuse large B-cell lymphoma (DLBCL) and osteoporotic fracture are both more common in older patients. Exposure to R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) is likely to increase the risk of fracture, but evidence is lacking to define fracture incidence in this group. Data on consecutive patients with DLBCL aged ≥70 years treated with 1 to 8 cycles of full or attenuated R-CHOP were retrospectively collected across 10 UK centers (2009-2019). Patients were followed up from starting R-CHOP for a minimum of 6 months and censored at 18 months; at last follow-up if <18 months; or at progression or death. Of 877 patients identified, 148 were excluded: 121 had progression or died before 6 months; 23 had follow-up <6 months. Across 729 remaining patients, the median age was 77 years, and 68% had an Eastern Cooperative Oncology Group performance status of 0 to 1. Eighty-one fractures occurred within 18 months of follow-up; 42 were symptomatic, including 30 requiring hospital attendance or admission. The cumulative fracture incidence was 6.2% (95% confidence interval [CI], 4.7-8.2) at 6 months; 9.7% (95% CI, 7.8-12.1) at 12 months; and 11.4% (95% CI, 9.3-14.0) at 18 months. Multivariate analysis identified a predisposing history (osteoporosis, osteopenia, prior fracture, and rheumatoid arthritis [RhA]), DLBCL bone involvement at baseline, and receipt of prephase steroids as independent risk factors for fracture. There is a clinically relevant fracture risk and significant associated morbidity in older patients receiving R-CHOP. Careful attention to bone health is warranted in older patients receiving R-CHOP. Randomized studies are required to better define the most effective strategies to reduce fracture risk.
Weekend and off-hour effects on the incidence of cerebral palsy: contribution of consolidated perinatal care
Authors: Toyokawa Satoshi , Hasegawa Junichi , Ikenoue Tsuyomu , Asano Yuri , Jojima Emi , Satoh Shoji , Ikeda Tomoaki , Ichizuka Kiyotake , Takeda Satoru , Tamiya Nanako , Nakai Akihito , Fujimori Keiya , Maeda Tsugio , Masuzaki Hideaki , Suzuki Hideaki , Ueda Shigeru
Published: September 2020

Objective

This study estimated the effects of weekend and off-hour childbirth and the size of perinatal medical care center on the incidence of cerebral palsy.

Methods

The cases were all children with severe cerebral palsy born in Japan from 2009 to 2012 whose data were stored at the Japan Obstetric Compensation System for Cerebral Palsy database, a nationally representative database. The inclusion criteria were the following: neonates born between January 2009 and December 2012 who had a birth weight of at least 2000 g and gestational age of at least 33 weeks and who had severe disability resulting from cerebral palsy independent of congenital causes or factors during the neonatal period or thereafter. Study participants were restricted to singletons and controls without report of death, scheduled cesarean section, or ambulance transportation. The controls were newborns, randomly selected by year and type of delivery (normal spontaneous delivery without cesarean section and emergency cesarean section) using a 1:10 case to control ratio sampled from the nationwide Japan Society of Obstetrics and Gynecology database.

Results

A total of 90 cerebral palsy cases and 900 controls having normal spontaneous delivery without cesarean section were selected, as were 92 cerebral palsy cases and 920 controls with emergent cesarean section. A significantly higher risk for cerebral palsy was found among cases that underwent emergent cesarean section on weekends (odds ratio [OR] 1.72, 95% confidence interval [CI] 1.06–2.81) and during the night shift (OR 2.29, 95% CI 1.30–4.02). No significant risk was found among normal spontaneous deliveries on weekends (OR 1.63, 95% CI 0.97–2.73) or during the quasi-night shift (OR 1.26, 95% CI 0.70–2.27). Regional perinatal care centers showed significantly higher risk for cerebral palsy in both emergent cesarean section (OR 2.35, 95% CI 1.47–3.77) and normal spontaneous delivery (OR 2.92, 95% CI 1.76–4.84).

Conclusion

Labor on weekends, during the night shift, and at regional perinatal medical care centers was associated with significantly elevated risk for cerebral palsy in emergency cesarean section.
NEMPD: a network embedding-based method for predicting miRNA-disease associations by preserving behavior and attribute information
Authors: Ji Bo-Ya , You Zhu-Hong , Chen Zhan-Heng , Wong Leon , Yi Hai-Cheng
Published: September 2020

Background

As an important non-coding RNA, microRNA (miRNA) plays a significant role in a series of life processes and is closely associated with a variety of Human diseases. Hence, identification of potential miRNA-disease associations can make great contributions to the research and treatment of Human diseases. However, to our knowledge, many existing computational methods only utilize the single type of known association information between miRNAs and diseases to predict their potential associations, without focusing on their interactions or associations with other types of molecules.

Results

In this paper, we propose a network embedding-based method for predicting miRNA-disease associations by preserving behavior and attribute information. Firstly, a heterogeneous network is constructed by integrating known associations among miRNA, protein and disease, and the network representation method Learning Graph Representations with Global Structural Information (GraRep) is implemented to learn the behavior information of miRNAs and diseases in the network. Then, the behavior information of miRNAs and diseases is combined with the attribute information of them to represent miRNA-disease association pairs. Finally, the prediction model is established based on the Random Forest algorithm. Under the five-fold cross validation, the proposed NEMPD model obtained average 85.41% prediction accuracy with 80.96% sensitivity at the AUC of 91.58%. Furthermore, the performance of NEMPD is also validated by the case studies. Among the top 50 predicted disease-related miRNAs, 48 (breast neoplasms), 47 (colon neoplasms), 47 (lung neoplasms) were confirmed by two other databases.

Conclusions

The proposed NEMPD model has a good performance in predicting the potential associations between miRNAs and diseases, and has great potency in the field of miRNA-disease association prediction in the future.
Automated classification of protein subcellular localization in immunohistochemistry images to reveal biomarkers in colon cancer
Authors: Xue Zhen-Zhen , Wu Yanxia , Gao Qing-Zu , Zhao Liang , Xu Ying-Ying
Published: September 2020

Background

Protein biomarkers play important roles in cancer diagnosis. Many efforts have been made on measuring abnormal expression intensity in biological samples to identity cancer types and stages. However, the change of subcellular location of proteins, which is also critical for understanding and detecting diseases, has been rarely studied.

Results

In this work, we developed a machine learning model to classify protein subcellular locations based on immunohistochemistry images of human colon tissues, and validated the ability of the model to detect subcellular location changes of biomarker proteins related to colon cancer. The model uses representative image patches as inputs, and integrates feature engineering and deep learning methods. It achieves 92.69% accuracy in classification of new proteins. Two validation datasets of colon cancer biomarkers derived from published literatures and the human protein atlas database respectively are employed. It turns out that 81.82 and 65.66% of the biomarker proteins can be identified to change locations.

Conclusions

Our results demonstrate that using image patches and combining predefined and deep features can improve the performance of protein subcellular localization, and our model can effectively detect biomarkers based on protein subcellular translocations. This study is anticipated to be useful in annotating unknown subcellular localization for proteins and discovering new potential location biomarkers.
Species delimitation in the cyanolichen genus Rostania
Authors: Košuthová Alica , Bergsten Johannes , Westberg Martin , Wedin Mats
Published: September 2020

Background

In this study, we investigate species limits in the cyanobacterial lichen genusRostania(Collemataceae, Peltigerales, Lecanoromycetes). Four molecular markers (mtSSU rDNA, β-tubulin, MCM7, RPB2) were sequenced and analysed with two coalescent-based species delimitation methods: the Generalized Mixed Yule Coalescent model (GMYC) and a Bayesian species delimitation method (BPP) using a multispecies coalescence model (MSC), the latter with or without an a priori defined guide tree.

Results

Species delimitation analyses indicate the presence of eight strongly supported candidate species. Conclusive correlation between morphological/ecological characters and genetic delimitation could be found for six of these. Of the two additional candidate species, one is represented by a single sterile specimen and the other currently lacks morphological or ecological supporting evidence.

Conclusions

We conclude thatRostaniaincludes a minimum of six species:R. ceranisca,R. multipunctata,R. occultata1,R. occultata2,R. occultata3, andR. occultata4,5,6. Three distinctNostocmorphotypes occur inRostania, and there is substantial correlation between these morphotypes andRostaniathallus morphology.
ComHapDet: a spatial community detection algorithm for haplotype assembly
Authors: Sankararaman Abishek , Vikalo Haris , Baccelli François
Published: September 2020

Background

Haplotypes, the ordered lists of single nucleotide variations that distinguish chromosomal sequences from their homologous pairs, may reveal an individual’s susceptibility to hereditary and complex diseases and affect how our bodies respond to therapeutic drugs. Reconstructing haplotypes of an individual from short sequencing reads is an NP-hard problem that becomes even more challenging in the case of polyploids. While increasing lengths of sequencing reads and insert sizes helps improve accuracy of reconstruction, it also exacerbates computational complexity of the haplotype assembly task. This has motivated the pursuit of algorithmic frameworks capable of accurate yet efficient assembly of haplotypes from high-throughput sequencing data.

Results

We propose a novel graphical representation of sequencing reads and pose the haplotype assembly problem as an instance of community detection on a spatial random graph. To this end, we construct a graph where each read is a node with an unknown community label associating the read with the haplotype it samples. Haplotype reconstruction can then be thought of as a two-step procedure: first, one recovers the community labels on the nodes (i.e., the reads), and then uses the estimated labels to assemble the haplotypes. Based on this observation, we propose – a novel assembly algorithm for diploid and ployploid haplotypes which allows both bialleleic and multi-allelic variants.

Conclusions

Performance of the proposed algorithm is benchmarked on simulated as well as experimental data obtained by sequencing Chromosome 5 of tetraploid biallelicSolanum-Tuberosum(Potato). The results demonstrate the efficacy of the proposed method and that it compares favorably with the existing techniques.
The relationship between the level of μ-opioid receptor (μORs) and postoperative analgesic use in patients undergoing septoplasty: a prospective randomized controlled trial
Authors: Gencer Muzaffer , Göçmen Ayşe Yeşim
Published: September 2020

Background

In this study, the μ-Opioid receptor activity was assessed pre-operatively for its association with postoperative pain level and second analgesic requirement in patients undergoing septoplasty.

Methods

In our prospective study, 120 adult patients underwent septoplasty from June 2015 to January 2019 were randomly divided into 2 pre-operative groups. The first group (n = 60) was patients given tramadol (1–2 mg/kg) for post-operative analgesia, and the second group (control group) (n = 60) was initially prescribed only fentanyl (1 μg/ kg-i.v.) in the induction. Acetaminophen with codeine analgesic 325/30 mg (p.o.) was used as an rescue painkiller in the post-operative period. The μ-Opioid receptor activity was investigated in pre-operative blood samples and compared to post-operative pain level and time required for second round of analgesic administration. The visual analogue score (VAS) was used to evaluate the post-operative pain degree (0 no pain; 10 worst pain). The patients’ post-operative VAS scores were evaluated upon arrival to recovery room, and at the 1st, 3rd, 7th, 10th, and 24th hour post-operative period.

Results

Demographic data and peri-operative variables were similar in both study group (p < 0.05).There was no significant difference between the receptor levels in both groups and the mean receptor level was 200.94 ± 15.34 pg/mL (max:489.92 ± 22.36 pg/mL, min: 94.56 ± 11.23 pg/mL).In patients who used tramadol as the levels of μ-Opioid receptors increased, VAS scores of patients and second analgesic use decreased in post-operative period.The VAS scores in patients with higher receptor levels were lower in the recovery room (p < 0.05), 1st (p < 0.05) and 3rd hours (p < 0.05).The VAS scores were lower in the tramadol group compared to the control group (p < 0.05).Number of secondary analgesic requirement was significantly lower in patients of the tramadol group with higher receptor levels compared to the ones with lower receptor (p < 0.05) for arrival at the recovery room and 1st hour. Patients in the tramadol group needed a second pain killer much later than patients in the control group.

Conclusions

Our study demonstrates that patients with higher μOR levels have a higher efficacy of opioid analgesic agents and an lesser need for additional analgesic agents.

Trial registration

This trial was registered retrospectively (The ACTRN: ACTRN12619001652167, registration date: 26/11/2019).
Traffic police officers’ use of first aid skills at work: a qualitative content analysis of focus group discussions in Dar Es Salaam, Tanzania
Authors: Ndile Menti L. , Saveman Britt-Inger , Lukumay Gift G. , Mkoka Dickson A. , Outwater Anne H. , Backteman-Erlanson Susann
Published: September 2020

Background

The World Health Organisation (WHO) recommends involving lay people in prehospital care. Several training programmes have been implemented to build lay responder first aid skills. Findings show that most programmes significantly improved participants’ first aid skills. However, there is a gap in knowledge of what factors influence the use of these skills in real situations. The current study aimed to describe police officers’ views on and experiences of factors that facilitate or hinder their use of trained first aid skills at work.

Methods

Thirty-four police officers participated in five focus group discussions. A structured interview guide was used to collect data. Interviews were audio-recorded and transcribed verbatim. Data were analysed using qualitative content analysis.

Results

We identified five categories of facilitators or hindrances. Training exposure was considered a facilitator; work situation and hospital atmosphere were considered hindrances; and the physical and social environments and the resources available for providing first aid could be either facilitators or hindrances.

Conclusion

Practical exposure during training is perceived to improve police officers’ confidence in applying their first aid skills at work. However, contextual factors related to the working environment need to be addressed to promote this transfer of skills.