bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh budaya terhadap keselamatan pasien di rumah sakit
Authors: rambe Fifi adelina
Published: December 2019

Hampir setiap tindakan medis menyimpan potensi resiko. Banyaknya jenis obat, jenis pemeriksaan dan juga prosedur, serta jumlah pasien dan staf Rumah Sakit yang cukup besardi rumah sakit , merupakan hal yang potensial bagi terjadinya kesalahan medis atau pun tindakan medis yang dilakukan oleh tenaga medis.Artinya kesalahan medis didefinisikan sebagai suatu Kegagalan tindakan medis yang telah direncanakan untuk diselesaikan tidak seperti yang diharapkan yaitu kesalahan tindakan atau perencanaan yang salah untuk mencapai suatu tujuan atau kesalahan perencanaan. Adapun tujuan dari pengaruh budaya terhadap keselamatan pasien dirumah sakit ini adalah apabila pasien memiliki budaya yang berbeda dengan perawat atau tenaga kerja kesehatan yang lain agar melakukan komunikasi . misalnya pasien ada larangan tertentu dari budaya nya yang bertentangan dengan tindakan medis yang akan di lakukan perawat terhadap pasien tersebut. Oleh karena itu perawat bertanya terlebuh dahulu kepada pasien itu agar tidak terjadi kesalah pahaman , atau pun sebelum melakukan tindakan nya perawat harus meminta izin terlebih dulu terhadap pasien ataupun keluarga pasien . semua orang memiliki budaya yang berbeda-beda. Kita sebagai perawat juga harus memahi budaya pasien kita . dan apabila pasien tersebut sudah mengizinkan kita melakukan tindakan yang akan di lakukan dan itu tidak melanggar budaya nya maka perawat melakukan tindakannya
PERAN INFROMASI DAN TEKNOLOGI TERHADAP MANAJEMEN PENDIDIKAN
Authors: Marnia Wira Marnia
Published: December 2019

The study ains to detemine the role of information and communication technology in education. The information and communication technology in general, including computers ( literacy) and information literacy, which means students recognize the teams used in information and communication techology. In the Qur’ran there are so many commads, statement, suggestions, satires and so on that subtantially lin islamic teachings to science and technology. The results of this study found that the role of information technology in education, in addition to helping students in learning also had a quite influentia r ole for teachers especially in the use of facilities to enrich teaching skills, and the Qur’ran as a quide and quidance for the development of science and technology in order to strengthen faith and improve human well being
POLA PEMANFAATAN TUMBUHAN BERKHASIAT OBAT OLEH MASYARAKAT DI SEKITAR KAWASAN HUTAN TAMAN WISATA ALAM KOTA SORONG
Authors: Saeni Fajrianto
Published: December 2019

Penelitian bertujuan untuk mengetahui mengidentifikasi dan mengetahui pola pemanfaatan tumbuhan berkhasiat obat oleh masyarakat disekitar kawasan hutan Taman Wisata Alam Kota Sorong. Jenis-jenis tumbuhan berkhasiat obat yang dimanfaatkan oleh masyarakat disekitar hutan Taman Wisata Alam Sorong ditemukan sebanyak 17 (tujuh belas) jenis yang terdiri dari 15 Famili. Pola Pemanfaatan tumbuhan berkhasiat obat oleh masyarakat sekitar hutan Taman Wisata Alam Sorong masih terbatas pada tingkat komponen ekosistem, dimana pemanfaatannya hanya terbatas pada skala konvensional (Conventional uses). Pemanfaatan bagian dari tumbuhan berkhasiat obat oleh masyarakat disekitar hutan Taman Wisata Alam Sorong meliputi buah, daun, kulit dan akar serta ada juga seluruh bagian herba tumbuhan tersebut, dimana proses pemanfaatanya bagian tumbuhan tersebut ada yang segar (basah) ada juga yang kering, ada yang murni dan ada juga yang mencampuri dengan jenis lain. (Jurnal ini telah terbit 01 juni 2015 di jurnal Median Universitas Muhammadiyah Sorong Fakultas Pertanian)
HUBUNGAN PENERAPAN KESELAMATAN PASIEN TERHADAP AKREDITASI RUMAH SAKIT
Authors: Marpaung Sri Harvita Sari
Published: December 2019

Latar belakang : Status akreditasi merupakan pengakuan bahwa rumah sakit sudah memenuhi standar ter-masuk didalamnya standar MPO pada rumah sakit dengan status akreditasi. Masih tingginya insiden keselamatan pasien pada beberapa laporan di Indonesia mengindikasikan lemahnya hubungan status akreditasi dan keselamatan pasien. Tujuan : untuk memberikan informasi mengenai hubungan penerapan penerapan keselamatan pasien dengan akreditasi rumah sakit. Metode : Rancangan penugasan kajian ini menggunakan buku teks, buku referensi, jurnal, e-journal (10 tahun terakhir) dengan menganalis, eksplorasi dan kajian bebas. Hasil : Perawat berpendapat bahwa akreditasi mendorong perawat untuk lebih memperhatikan upaya keselamatan pasien di rumah sakit, diantaranya penerapan standar opeasional prosedur yang lebih baik dalam upaya pencegahan infeksi, mobilisasi pasien, dan asuhan keperawatan. Selain itu akreditasi juga mendorong perawat melakukan pendokumentasian secara lengkap, mendorong perawat melakukan pendidikan kesehatan kepada pasien dan keluarga secara intensif serta mendorong dokumentasi yang terintegrasi sehingga menimbulkan komunikasi antar tim kesehatan yang merawat pasien. Pembahasan : hubungan penerapan keselamatan pasien dengan akreditasi rumah sakit. Kesimpulan : Akreditasi sangat mempengaruhi keselamatan pasien karena dengan akreditasi yang baik maka akan dapat memberikan hasil terbaik untuk keselamatan pasien.
Protocol for a Systematic Review of Masculinity and Relationship Satisfaction Among Men and Women
Authors: Jenkins Diana
Published: December 2019

Previous research has examined the relationship among masculinity and relationship outcomes and generally have found support that masculinity is related to lower relationship satisfaction. More specifically, men who adhere to traditional masculinity or who endorse traditional masculinity report lower relationship and sexual satisfaction, and women whose male partners adhere to and endorse more traditional masculinity also have lower relationship satisfaction. However, neither a meta-analysis nor a systematic review of how studies have operationalized and measured both masculinity and relationship satisfaction have been performed on this relationship. In addition, little is known whether studies using dyadic or individual participants are systematically different. To address these issues, a systematic review will be conducted examining the role of masculinity (adherence or endorsement) on relationship satisfaction for men and women. The implications of these findings will be addressed.
Protocol for a Systematic Review and Meta-Analysis on the Association of Parents and Teacher’s STEM-related Expectancy and Task-value Beliefs about Children with Children’s STEM-related Career Aspirations and Academic Achievement
Authors: Woods Bobbi
Published: December 2019

Eccles’s expectancy-value theory (EVT) has been used to understand students’ achievement-related beliefs in certain STEM domains such as math and science. Studies have started to explore the role that parents and teachers EVT beliefs have in influencing students STEM-related career interest. However, a clear picture of the magnitude of this effect is unclear because studies exploring this association often only focus on one specific STEM domain and on one age group (e.g. lower elementary, upper elementary, middle school, or high school). Given that parents and teachers play a large role in the lives of students, it is important to understand how their beliefs are related to the education and career decision of students. As such, the goal of this systematic review and meta-analysis is to examine the magnitude of the association between the STEM-related expectancy and task-value beliefs of parents/teachers about their children/students with their child/student’s STEM-related career aspirations and academic achievement. The findings of this systematic review and meta-analysis will be discussed in terms of the implications for STEM-related education
Retrospective Review of Adrenalectomy in a Tertiary Center in Nepal
Authors: Dhital Pawan , Rai Bipendra DK , Pradhan Manish , Poudyal Sujeet , Chapagain Suman , Chalise Pawan R , Luitel Bhoj R , Sharma Uttam K , Gyawali Prem R
Published: December 2019

Introduction: Adrenal gland surgery is a challenging art as it encompasses diverse physiological derangements which are even life-threatening. Also, it remains a medical finesse to rightly identify the correct patient who will benefit from surgery which include strong biochemical and radiological resource. Soundly performed surgery will lead to oncologic and homeostatic correction leading to near normal course.

Methods: This is a retrospective analysis of adrenalectomy cohort over three years in a tertiary center in Nepal identifying diagnosis, preoperative management and postoperative course. The objective of this study is to review the presentation, histopathology and clinical outcomes of patients operated for adrenal mass in our center.

Results: There were 42 surgeries performed via open approach. The number of adenoma, phaeochromocytoma, carcinoma and non-functioning tumor were 13, 16, 12 and one respectively. In most of the hypertensive patients, control was achieved with minimal drug and recurrences were observed in 25% of carcinoma in postoperative follow up.

Conclusion: A large proportion of operative adrenal mass are observed clinically in our setup. The surgical outcome is satisfactory but judicious perioperative management is essential.
Risk Factors for Gall Stone Diseases in Patients Presenting to General Practice Out Patient Department in a Tertiary Care Center in Nepal
Authors: Neupane Ram P. , Shrestha Tirtha M , Raut Shankar , Aacharya Ramesh P
Published: December 2019

Introduction: Gallstone disease (GSD) is a major public health problem that is associated with a number of risk factors. This study aims to analyze the risk factors of GSD in patients visiting General Practice Outpatient Department of Tribhuvan Universtiy Teaching Hospital.

Methods: A case-control study of 174 participants comprising 85 cases with GSD and 89 controls without GSD, as confirmed by ultrasonography of abdomen was conducted as hospital based in outpatient department of General practice, Tribhuvan University Teaching Hospital, Kathmandu from 1st February 2018 to 31st January, 2019. The participants were asked questions regarding putative risk factors for development of GSD and underwent physical and ultra sonographic examination. Risk factors included were age, sex, BMI, occupation, co-morbidities e.g. diabetes mellitus, hemolytic diseases, family history of GSD, smoking status, alcohol consumption, parity if applicable and dietary history. Data analysis was done by univariate method.

Results: The mean age of the case group was 47.82 years whereas mean age for the control was 46.51 years (p=0.355). 22% of cases were male and 78% were female where as in control group 29% were male (p=0.3030). Majority of the participants in both group were housewife by occupation and Hindu by religion. Mean BMI of the cases and control were 24.05 kg/m2 and 21.13kg/m2 respectively. BMI was found significant for the gall stone diseases (p=<0.001). Similarly, Diabetes mellitus was found significant for GSD (p=0.001). 98% cases and 61% in control group were Non-vegetarians with significant p value of 0.021. Smoking (p=0.005), Non-vegetarian diet (p=0.021), family history of gall stone disease (p<0.001) and parity (p<0.001) were also found significant for the gall stone disease.

Conclusion: High BMI, non-vegetarian diet, family history of gall stone disease, diabetes mellitus, smoking and increased parity were associated with gall stone diseases.
Diagnostic Accuracy of Peritoneoscopy to Determine the Cause of Low Serum Ascites Albumin Gradient
Authors: Parajuli Pawan , Bhandari Ramesh S , Pathak Rahul , Sharma Shashi , Khadga Prem K , Jha Anurag , Hamal Rabin , Kafle Brindeswari
Published: December 2019

Introduction: As cites, a common entity in practice of gastroenterology is path physiologically divided into high SAAG and low SAAG category, to rapidly classify, formulate a workup plan and expedite the diagnosis. The cause of low SAAG as cites is often due to local peritoneal cause e.g. peritoneal tuberculosis, peritoneal carcinomatosis etc, mandating the need of peritoneoscopy for definitive diagnosis. This study aims to present the peritoneoscopy and peritoneal biopsy result of patients with low SAAG as cites of uncertain etiology.

Methods: Peritoneoscopy was prospectively performed in 12 patients with low SAAG as cites of unclear etiology. Patients with low SAAG as cites and willing to give consent for peritoneoscopy were enrolled in the study. Patients underwent laparoscopic peritoneoscopy under general anesthesia and appropriate biopsies were taken during the procedure for histopathological analysis.

Results: Of the twelve patients with low SAAG enrolled in the study, 3 (25%) were male and 75% (9) were female. The success rate of the procedure was 100% and there was no procedure related complications. Specific findings were seen in all patients undergoing peritoneoscopy. Of the twelve patients, 9 (75%) patients has metastatic deposits in the peritoneum, 3 (25%) had benign etiology, 2/3rd (2) of whom had granulomatous deposits suggestive of tuberculosis and 1/3rd (1) had extensive dense adhesions and peritoneal fibrosis. Primary focus was revealed (ovary) in only 1 patient undergoing peritoneoscopy.

Conclusion: Peritoneoscopy with simultaneous biopsy is safe, efficient and accurate diagnostic method due to its high diagnostic capacity and low complication rate in selected patients who have low SAAG as cites of uncertain etiology.
Knowledge and Practice on Prevention of Complications of Diabetes Mellitus among Patients with Diabetes in a Tertiary Hospital
Authors: Acharya Om K , KC Takma , Shrestha Krishna D
Published: December 2019

Introduction: Diabetes is a major contributing factor for overall health status, morbidity, mortality and quality of life. Adequate knowledge and sufficient practice can prevent many possible diabetic complications. Hence, the objective of this study was to find out the knowledge and practice regarding prevention of complications of diabetes among diabetic patients.

Methods: A descriptive, cross sectional design was carried out in Tribhuvan University Teaching Hospital Kathmandu (TUTH). A total 124 diabetic patients who came for follow-up in endocrine Out Patient Department were selected through purposive sampling technique by using pre-tested structured interview schedule during four weeks. Data was analyzed by using the descriptive and inferential statistics with the help of Statistical Package of Social Science (SPSS) version 16.

Results: The study findings showed that 24.2% respondents had adequate knowledge about complications. More than half of the respondents had sufficient practice (52.4%) regarding prevention of diabetic complications. Association between knowledge and selected variables showed that sex and education level tends to be significantly associated and regarding practice, area of residence and duration of illness were significantly associated (p<0.05). There was a statistically significant (p<0.001) and average positive relationship (r=0.605) was found between knowledge and practice.

Conclusion: The study concluded that though only few respondents had adequate knowledge, more than half of the respondents had sufficient practice regarding preventing complications. This finding suggests awareness program regarding prevention of complications of diabetes mellitus should be launched periodically to increase knowledge and sufficient practice on prevention of diabetic complications.
Serum Vitamin D Level in Chronic Obstructive Pulmonary Disease and its Relation with Severity: A Single Centre Study
Authors: Pant Pankaj , Thapa Shovit , Das Santa K , Bam Niraj
Published: December 2019

Introduction: Chronic obstructive pulmonary disease (COPD) is a public health problem of epidemic proportion. Several studies have shown low serum vitamin D levels in patients with COPD. The aim of this study was to compare serum vitamin D level in patients with Global Initiative for Chronic Obstructive Lung Diseases (GOLD) COPD stage II, III and IV with controls and correlate serum vitamin D level with severity of COPD.

Methods: A cross sectional study was conducted from June 2014 to November 2015 at Tribhuvan University Teaching Hospital (TUTH). A total of 154 subjects were enrolled for study that consisted of 77 cases of COPD and 77 controls for comparison. Participants were taken from medical wards and outpatient department. COPD staging was done as per GOLD guidelines and stage II, III and IV were labeled as advanced COPD cases. Both descriptive and inferential statistics were performed in SPSS version 20.

Results: Stage II, III and IV COPD were 30%, 36% and 34% respectively. Mean serum vitamin D level was 15.16±7.19 ng/ml in COPD cases and 33.99±12.37 ng/ml in healthy controls showing statistically significant relation of low serum vitamin D in patients with advanced COPD (p <0.0001). Serum vitamin D was found to be in decreasing trend with increasing severity of COPD.

Conclusion: Patients with advanced COPD (GOLD stage II, III and IV) had low serum vitamin D levels compared to normal population and serum vitamin D level correlated with GOLD severity in Nepalese patients with COPD.
Challenges of Sustaining Elimination Status of Leprosy in Nepal
Authors: Parajuli Sudip , Pokhrel Dinesh B , Baskota Rabindra , Poudyal Amod , Paudel Upama
Published: December 2019

Introduction: The number of leprosy patients is increasing in Nepal even after declaration of elimination in 2010. The objective of this study was to review the status of leprosy after declaration of elimination in Nepal and to identify challenges to sustain elimination.

Methods: This was retrospective study conducted by reviewing the annual data published by Department of Health Services, Ministry of Health, and Government of Nepal from 2010 through 2018. In addition, one year hospital based data (2017/18) was retrieved from records of Department of Dermatology and Venereology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Results: The prevalence of leprosy was found to be 0.77/10,000 population in 2010 and 0.99/10,000 in 2018. The numbers of multibacillary (MB) cases (remained more than 50%) outnumbered paucibacillary (PB) cases throughout eight years.

Conclusion: The prevalence of leprosy is gradually increasing in Nepal with more number of multi bacillary cases detected in post-elimination era.
Batwing Technique in Large Volume Excision of Breast Lesions: Case Report
Authors: Khanal Suman , Singh Yogendra P , Sharma Rashmi
Published: December 2019

Oncoplastic surgical techniques are seeing widespread use for excision of large volume breast lesions. Batwing technique is one of the volume displacement techniques that can be used to manage lesions in central quadrant of the breast. Such techniques are still underused in Nepal. Here we present three cases with large volume benign breast lesions managed with simple, easy-to-learn technique of Batwing oncoplasty.
Presidentialization of Electorate’s Behavior in the Election to Voivodeship Sejmiks in 2018
Authors: Peszyński Wojciech
Published: December 2019

The main category in this article is electoral presidentialization, understood as a tendency of voters’ behavior to mirror the decisions typical for presidential elections. Here, the category under consideration is analyzed in two dimensions: leader effect and social approval for the organization of television debates of the leaders of two most important parties. The author explains the process in question on the basis of quantitative and percentage distribution of answers to two questions to be found in three editions of the nation-wide electorate study “Political Preferences”. This article concerns voters’ preferences in a survey that was conducted just after the self-government election in 2018. In order to grasp the specificity of electoral behavior in this particular voting, the analysis was conducted in a comparative manner, and the subject of comparison was the 2015 election to the Sejm. The results of studies organized in 2012 and 2013, when no election was organized in Poland, were also referred to in a necessary scope.
Syriza in power (2015-2019): A Review of Selected Aspects
Authors: Lorencka Małgorzata , Aravantinou Leonidi Giulia
Published: December 2019

What are the consequences of Syriza coming to power in Greece in 2015? Did it become a new Weimar Germany for the future Europe? In this article we test the hypothesis that winning two consecutive parliamentary elections in 2015 and forming a government contributed to a farther institutionalisation of this party within the rules of Greek democracy. This article is based on data from the Greek Ministry of Interior and the website of the Greek parliament. This text aims at presenting the process of transformation of Syriza - a radical, left-wing, anti-establishment and anti-austerity party into a governmental entity, pro systemic and accepting the principle of the democratic state of law. All this was due to the establishing of the governmental coalition with ANEL, a nationalist party; social-economic reforms; the reform of the electoral system for parliamentary elections; the proposal of a constitutional reform and the ending of the nearly 30-year dispute with Macedonia. The electoral failure during the parliamentary elections on the 7th of July 2019 finishes a 4-year governance of Syriza and enables us to try to evaluate this experiment for the first time. A key finding of our investigation is the need to highlight the respect for the democratic rules by Syriza during its government and its further institutionalisation as one of the main groupings of the contemporary party system in Greece.
Genetic features of the dopaminergic neurotransmitter system in patients with alcohol dependence and depression comorbidity
Authors: Nikolishin A. E. , Brodyansky V. M. , Chuprova N. A. , Solovieva A. V. , Kibitov A. O
Published: December 2019

Aim. Test the hypothesis about the effect of polymorphisms of the DA system on the risk of developing depression in patients with alcohol dependence. Material and methods. 104 patients: 64 patients with a combination of diagnoses of “alcohol dependence” and “depression” (F10.2 and F32, F33 according to ICD-10, average age 41.23 ± 9.903 years) and 40 patients with a diagnosis of alcohol dependence (F10 .2 according to ICD-10, average age 45.57 ± 10.853 years) and 113 control (average age 43.65 ± 4.318 years). Results. In patients with a combination of AD and depression, the frequency of occurrence of the C allele C polymorphism rs1611115 of the DBH gene is higher than in the control group (p = 0.087, trend). In patients with a combination of AD and depression, the frequency of occurrence of the A allele of the rs1108580 polymorphism of the DBH gene is higher than in patients with AD (p = 0.059, trend). In patients with AD allele A, the DBH gene rs1108580 polymorphism increases the risk of depression by 174.0% (p = 0.009), the DBH gene rs1108580 AA polymorphism increases the risk of depression by 684.1% (p = 0.010), the rs1108580 gene AG polymorphism rs1108580 in the gene DBH increases the risk of depression by 261.1% (p = 0.010). Conclusion. It has been shown for the first time that polymorphic variants of the rs1108580 locus of the DBH gene act as important risk factors for depression in patients with AD. Polymorphism rs1611115 of the DBH gene can also play an important role in the development of depression in patients with AD, which requires further study.
Epigenome editing of the potential enhancers of the schizophrenia risk genes: approaches for optimization of the genetic constructs
Authors: Abashkin D. A. , Kurishev A. O. , Smirnova S. V. , Karpov D. S. , Golimbet V. E.
Published: December 2019

Hereditary factors contribute significantly to the development of schizophrenia. However, despite many years of research, the genetic architecture and mechanisms of the participation of genetic factors in the development of schizophrenia are not well understood. Genome-wide analyzes of genetic associations in various non-coding regions of the genome, including gene enhancers, revealed many loci associated with an increased risk of schizophrenia. In the course of the analysis of the spatial structure of the genome, we revealed the interaction of these enhancers with the promoter regions of genes involved in the metabolism of neurons. To study in more detail the functions of these genes and the participation of enhancers in their regulation, we obtained plasmid and lentiviral constructs of a functionally active transcription repressor based on the CRISPR / SpyCas9 system, as well as the endonuclease system. The use of these constructs in studies of the functions of enhancers and genes associated with the metabolism and regulation of gene expression in neurons is discussed.
The role of genetic research with family design in the study of affective disorders
Authors: Kasyanov E. D. , Maso G. E. , Kibitov A. O.
Published: December 2019

Affective disorders (recurrent depressive disorder and bipolar affective disorder) are multifactorial and polygenic diseases, which suggests the involvement of multiple neurobiological mechanisms. The phenotype of affective disorders is a heterogeneous group of clinically similar psychopathological symptoms, which also makes it difficult to detect potential biomarkers and new therapeutic targets. To study families at high risk of developing affective disorders using both clinical and molecular genetic approaches can help to study the neurobiological basis of depressive conditions, as well as to identify endophenotypes of affective disorders. The most important criterion for an endophenotype is its heritability, which can be proved only within the framework of the family design of the study. Comprehensive clinical and molecular genetic studies based on family design have the best prospects.
Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy
Authors: Pozhidaev I. V. , Boiko A. S. , Kornetova E. G.
Published: December 2019

The use of atypical antipsychotic drugs has made metabolic disorders one of the most common side effect of pharmacotherapy for schizophrenic patients. The aim of this study was to assess the contribution of polymorphic variants of genes of the P450 cytochrome system to changes in body mass index in patients with schizophrenia. As a result of the study, we did not identify significant associations of genotypes and alleles of the studied polymorphic variants of the CYP2D6, CYP1A2, CYP2C19 genes with weight gain in patients with schizophrenia of Russian nationality of the Siberian region receiving antipsychotic therapy and can revealed neither protective nor predisposing effects. Metabolic syndrome and, increase in body weight especially, are complex side effect, and further studies is needed to increase successful exploration and identification of the genetic component and assess contribution.
The effectiveness of the preventive program aimed at the formation of sobriety in alcohol abusers does not depend on the level of genetic risk of substance abuse
Authors: Vantej V. B. , Jakovlev A. N. , Vitchinkina V. I.
Published: December 2019

Studied the duration of abstinence from alcohol depending on the level of genetic risk of substance abuse, calculated on the basis of the contribution of genomarkers dopamine system, the 35 adult males who abuse alcohol. It was established that the genetic risk is not associated with the duration of abstinence from alcohol in the conditions of sobriety control.
Study of the polymorphic variants of the PIP5K2A gene association with the comorbidity of alcoholism and affective disorders
Authors: Mikhalitskaya E. V. , Roshchina O. V. , Ivanova S. A. , Bokhan N. A.
Published: December 2019

One of the common pathogenetic mechanisms of the formation of alcohol dependence and depressive disorders can be a violation of the neurotransmitter systems, in particular — dopamine. Phosphatidylinositol-4-phosphate-5-kinase type 2 alpha (PIP5K2A) plays an important role in the regulation of neuronal excitability and synaptic dopamine neurotransmission. The aim of this study was to assess the presence of associations of the PIP5K2A gene polymorphic variants with the comorbid course of alcohol dependence and depressive disorders. This study showed differences in the frequency of the genotype distribution of 3 PIP5K2A gene polymorphisms (rs946961, rs1132816, and rs1417374) both between patient groups compared with the control group, and between the patient group and the group with the comorbid course of disorders.
Genetic Predictors of Lithium Response
Authors: Heilbronner U.
Published: December 2019

Lithium remains a first-line pharmacological treatment of bipolar disorder (BD). However, treatment response is heterogeneous, with several lines of evidence implicating genetic factors. Unfortunately, neither hypothesis-driven approaches nor initial genome-wide association studies (GWAS) were successful in identifying genetic drivers of response heterogeneity, probably due to low statistical power and different phenotype measurements. Recently, a GWAS of the Consortium of Lithium Genetics (ConLiGen) has identified four single nucleotide polymorphisms (SNPs) mediating response to lithium, located in genes for two long non-coding RNAs. This success was only possible by international collaboration and the use of an established lithium response scale. The findings await further replication.
Dopamine Genetics: Substance Use Disorders vs. Parkinson’s Disease
Authors: Carl Lin Z. , Hall F. S. , Bell R. L.
Published: December 2019

It is established that Substance use disorders (SUDs) and Parkinson’s Disease (PD) among many other neuropsychiatric disorders are dopamine (DA)-related brain disorders with strong heritability. However, it is unclear whether DA-associated genetic risks share commonality across these disorders. This study utilizes the Genotype and Phenotype Database (dbGaP), by downloading related genome-wide association studies (GWAS) for individual genotype/phenotypes. According to our results DA pathways are significantly implicated in the genetic etiology of both SUDs and PD but much more in the former. Epistatic effects may represent a major portion of missing heritability observed in current main effect-oriented GWAS analyses.
Ethical aspects for genomic research in psychiatry
Authors: Semenova N. V.
Published: December 2019

The genomic research is one of the most dynamically developing fields both in the worldwide and in Russia. Currently, the genetic approaches in psychiatry are used to solve the practical and scientific problems related to medical genetic counseling, identification of the genetic factors associated with characteristics of metabolism of medicines or development of their side effects, as well as to develop the new approaches to classification of psychiatric disorders. Given the complexity and the unresolved nature of the several methodological issues related to ethics and protection of the rights of patients with mental disorders, the legal regulation of genomic research in this category of patients is a specific interdisciplinary challenge which solution requires combining of the competencies of lawyers, medical ethics specialists, psychiatrists, psychologists, geneticists.
Therapeutic resistance in depression from the genetics and pharmacogenetics point of view
Authors: Mazo G. E. , Rukavishnikov G. V. , Kibitov A. O.
Published: December 2019

Current trends in the concept of therapeutically resistant depression (TRD) tend to narrow its very heterogeneous group of patients. One of the most rapidly developing areas in the biological paradigm of TRD is genetic research aimed at finding biomarkers for predicting the therapeutic response. Obviously, the genetic risks of TR are not limited to combinations of genome genetic variants, but it also has phenotypic manifestations at all levels of phenotype formation. According to the fundamental possibility of achieving remission states, therapeutic resistance can be divided into relative and absolute. At present, it can be said that patients with relative and absolute resistance represent two biologically heterogeneous groups, the isolation of which requires the development of special laboratory approaches that will contribute to the development of a personalized approach to therapy.
Post-GWAS era in genetics of schizophrenia
Authors: Golimbet V. E. , Golov A. K. , Kondratyev N. V.
Published: December 2019

Genome-wide association studies (GWASs) discovered multiple genetic variants associated with schizophrenia. Te next step (post-GWAS analysis) is aimed at identifying the causal genetic variants and biological mechanisms underlying the associations with disease risk. Te following strategies are considered: the study of transcriptional regulation in neuronal human cells and the use of epigenomic information for searching for regulatory elements involved in the pathogenesis of schizophrenia. Te frst strategy includes identifcation of neuronal enhancers, mapping of potential target genes and functional confrmation of enhancer-promoter interactions. Te second approach is focused on the identifcation of transcriptional factors, which appear to be master regulators of expression.
Exploring genetic predictors of naltrexone treatment response in opioid use disorder
Authors: Blokhina . Е. A. , Krupitsky E. М. , Kibitov А. O. , Palatkin V. Ya. , Yaroslavtseva T. S. , Verbitskaya Е. V. , Zvartau E. E.
Published: December 2019

Purpose: The present study was aimed to evaluate the effect of the opioid receptors genes and dopamine system genes polymorphisms on the treatment outcomes of opioid dependence with implantable and oral naltrexone in randomized double blinded double dummy placebo controlled clinical trial. Methods: 306 patients with opioid dependence were randomized in 3 treatment groups (102 ss in each). The first group received implantation of 1000 mg naltrexone every 2 months during the 6 months period + oral naltrexone placebo; the second group — placebo implant every 2 months + oral naltrexone (50mg/day), and the third group — placebo implant + oral naltrexone placebo. All enrolled participants provided blood sample at baseline for genetic analysis of polymorphisms in following genes: mu-opioid receptor (OPRM1), kappa-opioid receptor (OPRK1), catechol-O-methyltransferase (COMT), dopamine receptors types 2 (DRD2) and 4 (DRD4), dopamine-beta-hydroxylase, and dopamine transporter (DAT1). Results: Regardless of provided treatment several polymorphisms of tested genes were associated with high risk of relapse: allele L (2R) DRD4 120bp (p=0.05; OR(95% CI)=3.3(1.1-10.1) ); allele С DRD2 NcoI (р=0,051 OR(95% CI) = 2,86 (1,09 — 7,52); genotype 9.9 DAT VNTR40bp (р=0,04; RR(95% CI) = 1,4(1,3 — 1,5)); on the contrary variants of polymorphisms (СС+СТ)-(ТТ)) of genes (OPRK1- DRD2Ncol) increased the chance to complete the treatment program (р=0,004; OR(95% CI) = 7.4 (1.8 — 30.4)), Kaplan-Meier survival analysis, р=0,016). The probability of completing treatment program by carriers of all these above mentioned variants of polymorphisms (OPRK1DRD2Ncol) was higher for oral naltrexone group (p=0.016), lower for double placebo group (p=0.015), but did not influence treatment outcomes in naltrexone-implant group. Conclusion: Naltrexone-implant is an effective medication for treatment of opioid dependence and its effectiveness exceeds oral naltrexone and placebo. The study showed joint influence of opioid receptor genes and genes of dopaminergic system on the treatment outcomes of opioid dependence. Genetic analysis is useful for determining potential responders to naltrexone treatment of opioid dependence.
RDoC: integration or separation of neuroscience and psychopathology?
Authors: Akhapkin R. V.
Published: December 2019

The Research Domain Criteria (RDoC) project, the neurobiological research flagship in psychiatry, was originally introduced as an alternative to the traditional DSM and ICD classifications. However, RDoC and ICD / DSM can become complementary, rather than mutually exclusive. The clinical psychopathological method remains valuable because it’s the only source of directly observable data. Computational science is a promising tool for combining psychopathological and neurobiological data in future.
Genetic aspects of non-motor symptoms in Parkinson’s disease
Authors: Safonova N. Y.
Published: December 2019

Non-motor symptoms are common in Parkinson`s disease and reflect the multisystem nature of the disorder. Parkinson’s disease is highly heterogeneous in early clinical features and later outcomes. This makes classifying genetic subgroups of PD relevant to clinical research and practice, particularly if they are prognostically relevant. Non-motor sypmptoms may be detrimental to patients’ functional status and sense of well-being.
Modelling of Hardenability and Tempering of High-Strength Structural Steels
Authors: Latz A. , Kern A.
Published: December 2019

The increasing demands on heavy plates made of high-strength structural steels for heavy machine construction require increasingly extensive and faster systems for a reliable prediction of the mechanical-technological properties of the plates after hardening and tempering. Based on the results of Jominy end quench tests on about 100 steels, the computer program jominy was developed for high-strength steels to calculate the hardness acceptance and hardenability as well as the tempering behavior after accelerated cooling. Based on a known chemical analysis, the expected hardness can be calculated for any sheet thickness and position over the sheet cross section. jominy is intensively used for the optimization and development of materials and heat treatment processes to provide tailor-made products.
Introduction to the Special Section of Conference Proceedings from the 2018 Canadian Writing Centres Association
Authors: Fladd Nadine , Marken Liv C
Published: December 2019

In this special section of the Canadian Journal for the Study of Discourse and Writing/ Rédactologie (CJSDW/R), we are pleased to share three articles that were originally presented at the 2018 Canadian Writing Centres Association / L’Association canadienne des centres de rédaction (CWCA/ACCR) conference in Saskatoon, Saskatchewan. This introduction situates those articles within the context of the work of other writing centre scholars and practitioners at the conference. The 2018 CWCA conference call invited attendees to share and explore ways that we, as writing centre practitioners, can engage in anti-oppressive educational practices. 1 Participants in the conference took up the invitation to explore the 2018 theme, “Politics and the Writing Centre: Inquiry, Knowledge, Dialogue, and Action,” in many ways. In general, though, four main themes were evident throughout the conference: Indigeneity and decolonization, the politics of space, identity, and labour.
Mesoscale numerical modeling of the boundary atmospheric layer adapted to the north-western Black Sea region. Part 1. Mathematical problem formulation
Authors: Ivanova E. V.
Published: December 2019

The article presents a complete mathematical formulation of the problem of the boundary layer of the atmosphere and the interacting surface layers of the soil with the active layer of the sea adapted to the North-Western Black Sea Region through the inclusion of the coastline shape, relief elevation angles and climatic characteristics of soil moisture. The numerical model is a three-dimensional, unsteady, hydrostatic model with one- or two-parameter closure. The paper presents a detailed description of the applied sub-grid processes parameterizations such as cloudiness in the lower tier, flows of short- and long-wave radiation throughout thickness of the boundary layer and near the Earth, antigradient migration for basic meteorological variables in the presence of neutral or weakly stable stratification, components of water, heat and radiation balance, phase transitions of moisture in the atmosphere, and different parameterizations of turbulent processes used in the model. The possibilities of the model include description of neutral and stable boundary layers with consideration of the kinetic energy of vertical velocity fluctuations instead of the kinetic energy of longitudinal and transverse velocity fluctuations. Identification of the type of the boundary layer at a particular point in time is estimated using values of the Richardson number. In addition, in case of convective conditions presence, parameterization of dry convection and wet-convective adaptation may be implemented. At the boundaries of "free boundary layer – surface or near-water layer of air, air-soil and air-water" certain bonding conditions are to be set to ensure continuity of meteorological parameters or their flows. On the upper boundary of the free boundary layer actual values of meteorological parameters and necessary parameters, or corresponding values from the global atmospheric model are to set. At the lower boundary of the deep soil layer the invariance of the vertical temperature gradient of the active layer of the sea – the value of temperature which is equal to the value of the latter according to its climatic values in the considered season of the year is to be set. The presented model is the first approximation in numerical modeling of the boundary layer over the adapted territory and is designed for studying the thermodynamic structure of the boundary layer of the adapted territory, as well as for identifying the breeze effects over the terrain.
Method of critical control of atmospheric radiosounding data in the range of extreme deviations
Authors: Savenets M. V.
Published: December 2019

The paper presents a new method of critical control of atmospheric radiosounding data in the range of extreme deviations of air temperature, isobaric level elevation, relative humidity and wind components. The method was developed based on atmospheric radiosounding data taken from 9 Ukrainian aerological stations over the period of 1973–2018. “Buoyant” threshold values form the basis of the developed method. These values correspond to the deviation threshold for each of aerological characteristics where statistical distribution of such characteristics reaches a zero value for the first time. Departure from constant threshold values in favor of “buoyant” values allowed for consideration of the main features of aerological characteristics dispersion, dependence from altitude and difference of distribution parameters observed during daylight and at night time. Potential errors in the range of extreme deviations may be identified when the values go beyond the thresholds of "the distribution body". The total percentage of such overrange amounts to 0.2% in the middle and upper troposphere, 0.3–1.8% in the lower troposphere, and up to 2% in the stratosphere. At the second stage of the developed method potential errors are checked using partial vertical, partial horizontal and temporal control techniques. The second stage of control is implemented for the levels where time series reach at least 3700 values. It allows for accurate calculation of average multi-year values required for performing the horizontal control. Potential errors are considered as real ones if there is a confirmation of existence of three extreme deviations taken from the “neighbor stations – neighbor observation periods – neighbor isobaric levels” set. It means that a potential error should be confirmed with at least two different types of critical control. At high altitudes two confirmations are enough provided a conclusion is made following the results of different types of control. The developed critical control method allowed rejection of the claim about incorrectness of 568 values with their maximum deviations reaching 6.2 and -6.4 σ for the total period of observation. The critical control of extreme deviations and the physical permissible limits control form necessary components of the complex critical control of atmospheric radiosounding data. They provide input information used for horizontal, vertical and hydrostatic control techniques.
Application of the operator model of runoff formation to determine the average long-term values of maximum water discharge of spring flood in the Pivdenny Buh basin
Authors: Dokus A. A. , Ovcharuk V. A. , Shakirzanova Zh. R.
Published: December 2019

In the context of Ukraine's integration into the European Union and implementation of the main provisions of Directive 2007/60/EC which implies assessment of potential hydrological risks, long-term factors of their formation, in particular the effects of climate change and the trend of river water regime changes should be taken into consideration. With this in mind, given the presence of both current long-term tendencies to reduction of runoff layers (volumes) and maximum discharge of water of spring flood across the Ukrainian rivers there is an important task to identify, using the modern initial data, both the average long-term values of these characteristics and different probability of their exceedance probability.

For the first time, the authors of the study implemented an operator model of runoff formation to determine the average long-term values of maximum water discharge of spring flood in the basin of the Pivdenny Buh using meteorological characteristics (snowpack and precipitation) and runoff coefficients as basic parameters.

The model was applied to determine the maximum runoff modules of spring floods for the rivers with a wide range of catchment areas affected by different physical and geographical conditions within the Pivdenny Buh Basin.

Application of the operator model allowed the authors of the article to calculate and summarize all input parameters of the calculation model, including those obtained from observational data (snowpack, precipitation) and those that can't be measured by the hydrometeorological network (runoff coefficient, temporal irregularity coefficient and duration of surface inflow of snowmelt and rain water, transformational function of the flood waves layering under the influence of channel lag, coefficient of channel and floodplain regulation) for the rivers of the Pivdenny Buh Basin.

The verifying calculation related to determination of the average long-term values of the maximum modules of spring flood runoff using  the operator model showed satisfactory concordance with the initial data and this allowed recommending it for practical application for the rivers of the Pivdenny Buh Basin, including those that haven't been studied from the hydrological perspective.