bluuebunny/crossref_metadata_2025 huggingface dataset:
Pan-azole- and multi-fungicide-resistant
Aspergillus fumigatus
is widespread in the United States
Authors: Celia-Sanchez B. N. , Mangum B. , Gómez Londoño L. F. , Wang C. , Shuman B. , Brewer M. T. , Momany M.
Published: April 2024

Aspergillus fumigatus
is an important global fungal pathogen of humans. Azole drugs are among the most effective treatments for
A. fumigatus
infection. Azoles are also widely used in agriculture as fungicides against fungal pathogens of crops. Azole-resistant
A. fumigatus
has been increasing in Europe and Asia for two decades where clinical resistance is thought to be driven by agricultural use of azole fungicides. The most prevalent mechanisms of azole resistance in
A. fumigatus
are tandem repeats (TR) in the
cyp51A
promoter coupled with mutations in the coding region which result in resistance to multiple azole drugs (pan-azole resistance). Azole-resistant
A. fumigatus
has been isolated from patients in the United States (U.S.), but little is known about its environmental distribution. To better understand the distribution of azole-resistant
A. fumigatus
in the U.S., we collected isolates from agricultural sites in eight states and tested 202 isolates for sensitivity to azoles. We found azole-resistant
A. fumigatus
in agricultural environments in seven states showing that it is widespread in the U.S. We sequenced environmental isolates representing the range of U.S. sample sites and compared them with publicly available environmental worldwide isolates in phylogenetic, principal component, and ADMIXTURE analyses. We found worldwide isolates fell into three clades, and TR-based pan-azole resistance was largely in a single clade that was strongly associated with resistance to multiple agricultural fungicides. We also found high levels of gene flow indicating recombination between clades highlighting the potential for azole-resistance to continue spreading in the U.S.

IMPORTANCE

Aspergillus fumigatus
is a fungal pathogen of humans that causes over 250,000 invasive infections each year. It is found in soils, plant debris, and compost. Azoles are the first line of defense antifungal drugs against
A. fumigatus
. Azoles are also used as agricultural fungicides to combat other fungi that attack plants. Azole-resistant
A. fumigatus
has been a problem in Europe and Asia for 20 years and has recently been reported in patients in the United States (U.S.). Until this study, we did not know much about azole-resistant
A. fumigatus
in agricultural settings in the U.S. In this study, we isolated azole-resistant
A. fumigatus
from multiple states and compared it to isolates from around the world. We show that
A. fumigatus
which is resistant to azoles and to other strictly agricultural fungicides is widespread in the U.S.
Automated detection of methicillin-resistant
Staphylococcus aureus
with the MRSA CHROM imaging application on BD Kiestra Total Lab Automation System
Authors: McElvania Erin , Mindel Susan , Lemstra Jaap , Brands Karin , Patel Parul , Good Caryn E. , Morel Didier , Orny Cedrick , Volle Jean-Marc , Desjardins Marc , Rhoads Daniel
Published: April 2024

The virulence of methicillin-resistant
Staphylococcus aureus
(MRSA) and its potentially fatal outcome necessitate rapid and accurate detection of patients colonized with MRSA in healthcare settings. Using the BD Kiestra Total Lab Automation (TLA) System in conjunction with the MRSA Application (MRSA App), an imaging application that uses artificial intelligence to interpret colorimetric information (mauve-colored colonies) indicative of MRSA pathogen presence on CHROMagar chromogenic media, anterior nares specimens from three sites were evaluated for the presence of mauve-colored colonies. Results obtained with the MRSA App were compared to manual reading of agar plate images by proficient laboratory technologists. Of 1,593 specimens evaluated, 1,545 (96.98%) were concordant between MRSA App and laboratory technologist reading for the detection of MRSA growth [sensitivity 98.15% (95% CI, 96.03, 99.32) and specificity 96.69% (95% CI, 95.55, 97.60)]. This multi-site study is the first evaluation of the MRSA App in conjunction with the BD Kiestra TLA System. Using the MRSA App, our results showed 98.15% sensitivity and 96.69% specificity for the detection of MRSA from anterior nares specimens. The MRSA App, used in conjunction with laboratory automation, provides an opportunity to improve laboratory efficiency by reducing laboratory technologists’ labor associated with the review and interpretation of cultures.
Atom Chip and Diffraction Grating for the Laser Cooling of Ytterbium Atoms
Authors: Vyalykh A. P. , Skakunenko P. I. , Shishova M. V. , Semenko A. V. , Afanasiev A. E. , Belotelov G. S. , Sutyrin D. V. , Balykin V. I.
Published: April 2024

The possibility of using an atom chip and a diffraction grating to form a compact magneto-optical trap for ytterbium atoms, which can be used to develop compact atomic interferometers and optical clocks based on ultracold atoms, has been studied. An experiment on the laser cooling of the 171Yb and 174Yb isotopes in a first‑stage magneto-optical trap has been carried out to determine initial requirements for the mentioned elements. The design of the atom chip forming a magnetic field gradient up to 60 G/cm has been calculated. The optimal configurations of the diffraction grating that allow forming both the first- and second-stage magneto-optical traps have been evaluated.
SSR: Solving Named Entity Recognition Problems via a Single-stream Reasoner
Authors: Zhang Yuxiang , Wang Junjie , Zhu Xinyu , Sakai Tetsuya , Yamana Hayato
Published: April 2024

Information Extraction (IE) focuses on transforming unstructured data into structured knowledge, of which Named Entity Recognition (NER) is a fundamental component. In the realm of Information Retrieval (IR), effectively recognizing entities can substantially enhance the precision of search and recommendation systems. Existing methods frame NER as a sequence labeling task, which requires extra data and, therefore may be limited in terms of sustainability. One promising solution is to employ a Machine Reading Comprehension (MRC) approach for NER tasks, thereby eliminating the dependence on additional data. This process encounters key challenges, including: (1) Unconventional predictions; (2) Inefficient multi-stream processing; (3) Absence of a proficient reasoning strategy. To this end, we present the Single-Stream Reasoner (SSR), a solution utilizing a reasoning strategy and standardized inputs. This yields a type-agnostic solution for both flat and nested NER tasks, without the need for additional data. On ten NER benchmarks, SSR achieved state-of-the-art results, highlighting its robustness. Furthermore, we illustrated its efficiency through convergence, inference speed, and low-resource scenario performance comparisons. Our architecture displays adaptability and can effortlessly merge with various foundational models and reasoning strategies, fostering advancements in both the IR and IE fields.
Navigating AI Regulation in Africa: Challenges and Considerations
Authors: Liu Shaoshan
Published: April 2024

While most discussions about Artificial Intelligence (AI) regulations focus on advanced economies, such as OECD countries [1,2], this series of articles systematically examines the AI regulation challenges in emerging economies of the Global South. In this piece, we navigate AI regulation challenges and considerations in Africa [3].
Insight into the function of voltage-sensing phosphatase in hindgut-derived pseudoplacenta of a viviparous teleost Xenotoca eiseni
Authors: Ratanayotha Adisorn , Iida Atsuo , Nomura Jumpei , Hondo Eiichi , Okamura Yasushi , Kawai Takafumi
Published: April 2024

We investigate the voltage-sensing phosphatase (VSP) in Xenotoca eiseni, a viviparous fish whose intraovarian embryos utilize trophotaenia for nutrient absorption. Although X. eiseni VSP (Xe-VSP) shares key features with known VSPs, its distinct voltage sensitivity arises from species-specific amino acid variation. Xe-VSP in trophotaenia epithelium suggests its involvement in nutrient absorption, similar to VSP in zebrafish enterocytes and potentially in species with similar absorptive cells. Our findings highlight the potential role of VSP across species.
Performance and perceived fatigability across the intensity spectrum: role of muscle mass during cycling
Authors: Zhang Jenny , Murias Juan M. , MacInnis Martin J. , Aboodarda Saied J. , Iannetta Danilo
Published: April 2024

We investigated the modulatory role of muscle mass on performance and perceived fatigability across the entire intensity spectrum. Despite similar time-to-task failure, single-leg cycling resulted in greater impairments in muscle contractile function within the heavy- and severe-intensity domains, but not the moderate- and extreme-intensity domains. Perceived fatigue, pain, and effort were similar between cycling modes. This indicates that the modulatory role of muscle mass on the extent of performance fatigability is intensity domain-dependent.
Physics-Informed Neural Networks for Solving High-Index Differential-Algebraic Equation Systems Based on Radau Methods
Authors: Chen Jiasheng , Tang Juan , Yan Ming , Lai Shuai , Liang Kun , Lu Jianguang , Yang Wenqiang
Published: March 2024

As is well known, differential algebraic equations (DAEs), which are able to describe dynamic changes and underlying constraints, have been widely applied in engineering fields such as fluid dynamics, multi-body dynamics, mechanical systems, and control theory. In practical physical modeling within these domains, the systems often generate high-index DAEs. Classical implicit numerical methods typically result in varying order reduction of numerical accuracy when solving high-index systems. Recently, the physics-informed neural networks (PINNs) have gained attention for solving DAE systems. However, it faces challenges like the inability to directly solve high-index systems, lower predictive accuracy, and weaker generalization capabilities. In this paper, we propose a PINN computational framework, combined Radau IIA numerical method with an improved fully connected neural network structure, to directly solve high-index DAEs. Furthermore, we employ a domain decomposition strategy to enhance solution accuracy. We conduct numerical experiments with two classical high-index systems as illustrative examples, investigating how different orders and time-step sizes of the Radau IIA method affect the accuracy of neural network solutions. For different time-step sizes, the experimental results indicate that utilizing a 5th-order Radau IIA method in the PINN achieves a high level of system accuracy and stability. Specifically, the absolute errors for all differential variables remain as low as 10−6, and the absolute errors for algebraic variables are maintained at 10−5. Therefore, our method exhibits excellent computational accuracy and strong generalization capabilities, providing a feasible approach for the high-precision solution of larger-scale DAEs with higher indices or challenging high-dimensional partial differential algebraic equation systems.
Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China
Authors: Li Jun , Gao Jingyan , Huang Min , Fu Xiaoyun , Fu Bao
Published: April 2024

Aim. To compare the clinical characteristics of survival and nonsurvival patients with severe acute pancreatitis (SAP) and explore the risk of mortality in SAP patients. Methods. This was a single‐center retrospective study performed in a severe acute pancreatitis diagnosis and treatment center. According to the outcome, SAP patients were divided into survival group and nonsurvival group. One‐way ANOVA or independent t‐test was used to compare the clinical characteristics of two groups of patients. Multivariate retrospective analysis was used to identify risk factors for mortality in SAP patients. Results. A total of 486 SAP patients were included in the study, and the 90‐day mortality for SAP patients was 13.58%. The common etiologies of SAP are biliary tract diseases (69.75%) and hyperlipidemia (17.28%). The most common complications caused by SAP were organ failure (55.14%), ARDS (50.62%), AKI (30.45%), sepsis (27.16%), and abdominal fluid collection (27.57%). There were differences in age, complications, and medical intervention between the nonsurvival group and the survival group. The main causes of death were infection (46.97%), abdominal bleeding (28.79%), and organ failure (9.09%). The binary logistic regression analysis showed that there were significant differences in age, AKI, sepsis, abdominal hemorrhage, organ failure, laparotomy, creatinine, and APTT between the nonsurvival group and the survival group. Conclusion. Age, AKI, sepsis, abdominal hemorrhage, and organ failure are risk factors for mortality in SAP patients. SAP patients with high creatinine and prolonged APTT upon admission require doctors to be vigilant. The main cause of death in SAP patients is pancreatitis‐related organ failure and secondary infection.
Parathyroid Hormone is Negatively Correlated with Glycated Hemoglobin in Newly Diagnosed Type 2 Diabetic Patients
Authors: He Xueqing , Liu Man , Ding Xiaoyu , Bian Nannan , Wang Jiaxuan , Wang Guang , Liu Jia
Published: April 2024

Objective. The growing evidence shows that parathyroid hormone (PTH) may affect glucose metabolism. However, the relationship between them is still controversial among diabetic patients. The current study aimed to investigate the relationship between PTH and glucose metabolism in the patients with newly diagnosed type 2 diabetes (T2D). Methods. A total of 532 participants, including 387 patients with newly diagnosed T2D and 145 healthy controls, were recruited in the present study. PTH and metabolic parameters were measured in all participants. Results. The PTH levels were significantly lower in the newly diagnosed T2D patients compared with the control group (35.10 (25.90, 47.20) vs. 47.15 (35.83, 58.65) pg/ml, P<0.001). The T2D patients with a higher glycated hemoglobin (HbA1c) tertile had lower PTH levels than the patients with a lower HbA1c tertile (32.90 (24.85, 41.40) vs. 37.50 (26.10, 54.55) pg/ml, P<0.001). Spearman correlation analysis showed that PTH was positively correlated with the body mass index (BMI), fasting insulin (FINS), homeostasis model assessment of β-cell function (HOMA-β), and homeostasis model assessment of insulin resistance (HOMA-IR) and negatively correlated with HbA1c, blood calcium (Ca), blood phosphorus (P), and 25-hydroxyvitamin D3 (25-OH-D3). Multiple linear regression analysis demonstrated that PTH was significantly associated with HbA1c (β = −1.475, P=0.003) and HOMA-β (β = 0.090, P=0.001) after adjusting for age, sex, BMI, season, 25-OH-D3, Ca, and P. Conclusion. PTH was negatively correlated with HbA1c in the newly diagnosed T2D patients. Our results suggested that the PTH level within the reference range is related to islet β-cell function and hyperglycemia.
Response of Whitefly Population to Rabbit Urine Foliar Spray on Tomato (Solanum lycopersicum L.)
Authors: Mutua Elvis Kalonzo , Mwangi Mariam , Gaoqiong Liu , Nyaanga Jane
Published: April 2024

Whiteflies greatly contribute to low yields and quality in tomato production. Continuous use of synthetic pesticides leads to whiteflies developing resistance to these pesticides. This research aimed at promoting the use of rabbit urine as a biopesticide against whiteflies in tomato production. Although rabbit urine is been used as a biopesticide against different pests, the best concentration to control whiteflies in tomato production is unknown. Six treatments compared in the two experiments of this study included: 2 L rabbit urine : 9 L water; 2 L rabbit urine : 6 L water; 2 L rabbit urine : 3 L water; 2 L rabbit urine : 0 L water; 0 L rabbit urine : 2 L water, and 20 mL Duduthrin 1.75EC : 20 L water. The first experiment was conducted in a randomized complete block design with six treatments and four blocks to investigate the effects of rabbit urine on the control of whitefly eggs, nymphs, and adults. The second experiment was conducted in a completely randomized design to determine the effect of rabbit urine on the bioactivity of adult whiteflies. Results indicated that plots treated with rabbit urine foliar spray registered reduced populations of whitefly eggs, nymphs, and adults, and lower LT50 values of repelling and killing compared to the negative control (0 L rabbit urine : 2 L water). However, a high ratio of rabbit urine caused significant scorching to tomato leaves. A solution of 2 L rabbit urine : 6 L water optimally controls whiteflies without scorching the plant foliage. Rabbit urine has both repelling and killing effects on whiteflies. In the future, further research can be conducted to investigate the effect of rabbit urine on populations of other important insect pests of tomato.
Supplementary Table 1 from Integrating AI-Powered Digital Pathology and Imaging Mass Cytometry Identifies Key Classifiers of Tumor Cells, Stroma, and Immune Cells in Non–Small Cell Lung Cancer
Authors: Rigamonti Alessandra , Viatore Marika , Polidori Rebecca , Rahal Daoud , Erreni Marco , Fumagalli Maria Rita , Zanini Damiano , Doni Andrea , Putignano Anna Rita , Bossi Paola , Voulaz Emanuele , Alloisio Marco , Rossi Sabrina , Zucali Paolo Andrea , Santoro Armando , Balzano Vittoria , Nisticò Paola , Feuerhake Friedrich , Mantovani Alberto , Locati Massimo , Marchesi Federica
Published: April 2024

Supplementary Table 1
Supplemental Table S3 from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

Supplemental Table S3. Total paired reads* (x1,000,000) for each tumor tissue sample associated with a diffuse glioma.
Supplemental Figure S9 from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

Supplemental Figure S9. Read depth, variant allele frequency (VAF), and counts for detected vs. missed variants.
Supplemental Figure S18 from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

Supplemental Figure S18. Copy number variation (CNV) detection demonstrates differences in CNVs between samples from the same patient.
Supplemental Figure S17 from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

Supplemental Figure S17. A heatmap of all discovered somatic mutations demonstrates the diversity of genes involved and the clustering of mutations in specific genes associated with different adult diffuse gliomas.
Supplement 5 from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

TXT file of positions on custom-designed panel to exclude during analysis because of high error rate.
Supplement 2 from Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas
Authors: Underhill Hunter R. , Karsy Michael , Davidson Christian J. , Hellwig Sabine , Stevenson Samuel , Goold Eric A. , Vincenti Sydney , Sellers Drew L. , Dean Charlie , Harrison Brion E. , Bronner Mary P. , Colman Howard , Jensen Randy L.
Published: April 2024

Methodology for consensus sequence determination.
Supplementary Figure S8 from Human Tumor–Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis
Authors: Singhal Sunil , Rao Abhishek S. , Stadanlick Jason , Bruns Kyle , Sullivan Neil T. , Bermudez Andres , Honig-Frand Adam , Krouse Ryan , Arambepola Sachinthani , Guo Emily , Moon Edmund K. , Georgiou George , Valerius Thomas , Albelda Steven M. , Eruslanov Evgeniy B.
Published: April 2024

Supplementary Figure S8. (A and B) Representative experiment and summary results showing the effect of blood and tumor FcR+ effectors on the growth of GFP+A549 tumor cell spheroids in the presence of cetuximab (1ug/ml). Experiments were performed as described in supplemental figure 5 (A and B). Original magnification x10. Scale bar, 400 µm. Data are represented as mean ± SEM. Wilcoxon matched pairs test (n=6). Indicated FcR+ effectors were freshly isolated for all experiments. (C) Flow cytometry histogram showing the expression of EGFR on the surface of H1975 tumor cell line in comparison with A431 and A549 tumor cells. (D and E) Cumulative flow cytometry results showing the different levels of trogocytosis and killing activity mediated by blood and tumor FcR+ effectors co-cultured with PKH67+ H1975 tumor cells at a 50:1 E:T ratio in the presence of cetuximab or isotype control Abs for 12 hrs. All comparisons used one-way ANOVA with Turkey’s multiple comparisons tests. All data represented as mean ± SEM. FcR+ effectors were freshly isolated for all experiments. IC-isotype control Ab.
Movie#3 from Human Tumor–Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis
Authors: Singhal Sunil , Rao Abhishek S. , Stadanlick Jason , Bruns Kyle , Sullivan Neil T. , Bermudez Andres , Honig-Frand Adam , Krouse Ryan , Arambepola Sachinthani , Guo Emily , Moon Edmund K. , Georgiou George , Valerius Thomas , Albelda Steven M. , Eruslanov Evgeniy B.
Published: April 2024

Suppl movie 3, Neutrophil sublethal trogocytosis
Movie#1 from Human Tumor–Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis
Authors: Singhal Sunil , Rao Abhishek S. , Stadanlick Jason , Bruns Kyle , Sullivan Neil T. , Bermudez Andres , Honig-Frand Adam , Krouse Ryan , Arambepola Sachinthani , Guo Emily , Moon Edmund K. , Georgiou George , Valerius Thomas , Albelda Steven M. , Eruslanov Evgeniy B.
Published: April 2024

Suppl movie 1, Mph Daudi phagocytosis
Supplementary Methods and References from PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
Authors: Yamamoto Takehiro , Hayashida Tetsu , Masugi Yohei , Oshikawa Kiyotaka , Hayakawa Noriyo , Itoh Mai , Nishime Chiyoko , Suzuki Masami , Nagayama Aiko , Kawai Yuko , Hishiki Takako , Matsuura Tomomi , Naito Yoshiko , Kubo Akiko , Yamamoto Arisa , Yoshioka Yujiro , Kurahori Tomokazu , Nagasaka Misa , Takizawa Minako , Takano Naoharu , Kawakami Koji , Sakamoto Michiie , Wakui Masatoshi , Yamamoto Takushi , Kitagawa Yuko , Kabe Yasuaki , Horisawa Kenichi , Suzuki Atsushi , Matsumoto Masaki , Suematsu Makoto
Published: April 2024

Methods and References
Table S1 from The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin
Published: April 2024

Patient characteristics of primary AML patient samples
Supplementary Methods from The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin
Published: April 2024

Supplementary Methods
Supplementary Data - THP-1 metabolomics from The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin
Published: April 2024

THP-1 metabolomics data
Supplementary Fig.S12 from PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer
Authors: Yamamoto Takehiro , Hayashida Tetsu , Masugi Yohei , Oshikawa Kiyotaka , Hayakawa Noriyo , Itoh Mai , Nishime Chiyoko , Suzuki Masami , Nagayama Aiko , Kawai Yuko , Hishiki Takako , Matsuura Tomomi , Naito Yoshiko , Kubo Akiko , Yamamoto Arisa , Yoshioka Yujiro , Kurahori Tomokazu , Nagasaka Misa , Takizawa Minako , Takano Naoharu , Kawakami Koji , Sakamoto Michiie , Wakui Masatoshi , Yamamoto Takushi , Kitagawa Yuko , Kabe Yasuaki , Horisawa Kenichi , Suzuki Atsushi , Matsumoto Masaki , Suematsu Makoto
Published: April 2024

Fig.S12
Figure S1 from The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Authors: Su Yongwei , Carter Jenna L. , Li Xinyu , Fukuda Yu , Gray Ashley , Lynch John , Edwards Holly , Ma Jun , Schreiner Patrick , Polin Lisa , Kushner Juiwanna , Dzinic Sijana H. , Buck Steven A. , Pruett-Miller Shondra M. , Hege-Hurrish Katie , Robinson Camenzind , Qiao Xinan , Liu Shuang , Wu Shuangshuang , Wang Guan , Li Jing , Allen Joshua E. , Prabhu Varun V. , Schimmer Aaron D. , Joshi Dhananjay , Kalhor-Monfared Shiva , Watson Iain D. G. , Marcellus Richard , Isaac Methvin B. , Al-awar Rima , Taub Jeffrey W. , Lin Hai , Schuetz John D. , Ge Yubin
Published: April 2024

Supplementary Figure S1
SFigure7 from Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia
Authors: Raucci Franca , Vernieri Claudio , Di Tano Maira , Ligorio Francesca , Blaževitš Olga , Lazzeri Samuel , Shmahala Anastasiya , Fragale Giuseppe , Salvadori Giulia , Varano Gabriele , Casola Stefano , Buono Roberta , Visco Euplio , de Braud Filippo , Longo Valter D.
Published: April 2024

SFigure7
Table S2B from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

Differentially expressed genes of the malignant subclusters.
Table S1E from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

List of antibodies used in the study.
Table S1D from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

List of shRNA or siRNA sequences used in this study.
Table S1B from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

Summary of patient characteristics (paraffin osteosarcoma tissue sections for immunohistochemistry staining).
Table S1A from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

Clinical information of scRNA-seq samples.
Figure S7 from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

CXCL14 binds to heterodimeric integrin α11β1.
Figure S6 from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

CXCL14-activated TGFβ+ fibroblasts foster a lung-metastatic niche in osteosarcoma.
Figure S3 from Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche
Authors: Xu Yanyang , Deng Chuangzhong , Chen Hongmin , Song YiJiang , Xu Huaiyuan , Song Guohui , Wang Xinliang , Luo Tianqi , Chen Weiqing , Ma Jiahui , Zeng Anyu , Huang Shujing , Chen Zhihao , Fu Jianchang , Gong Ming , Tai Yi , Huang Anfei , Feng Huixiong , Hu Jinxin , Zhu Xiaojun , Tang Qinglian , Lu Jinchang , Wang Jin
Published: April 2024

CXCL14 expression is associated with the activation of stromal fibroblasts in the osteosarcoma TME.
Table S1 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
Authors: Monteith Andrew J. , Ramsey Haley E. , Silver Alexander J. , Brown Donovan , Greenwood Dalton , Smith Brianna N. , Wise Ashley D. , Liu Juan , Olmstead Sarah D. , Watke Jackson , Arrate Maria P. , Gorska Agnieszka E. , Fuller Londa , Locasale Jason W. , Stubbs Matthew C. , Rathmell Jeffrey C. , Savona Michael R.
Published: April 2024

Table S1: Metabolomics Raw Data
Figure S3 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
Authors: Monteith Andrew J. , Ramsey Haley E. , Silver Alexander J. , Brown Donovan , Greenwood Dalton , Smith Brianna N. , Wise Ashley D. , Liu Juan , Olmstead Sarah D. , Watke Jackson , Arrate Maria P. , Gorska Agnieszka E. , Fuller Londa , Locasale Jason W. , Stubbs Matthew C. , Rathmell Jeffrey C. , Savona Michael R.
Published: April 2024

Figure S3: CRISPR technology disrupts target genes. Expressions of (A) BRD4, (B, C) LDHB, and (C) MCT1 were disrupted in the indicated cell lines by CRISPR. The percent indel efficiency of the genetic disruption was quantified by TIDE analysis of Sanger sequencing relative to scramble control after 72 hr. (B) Cells were treated with BETi (0.15 uM) for 48 hr and viability quantified by a fluorescence plate reader. and Each point represents the mean value obtained from cell lines from an individual experiment (n=3). (D) Cells were transfected with siRNA targeting MCT4 or a scramble control. Subsequently, cells were treated with BETi for 48 hr and MCT1 and MCT4 protein levels quantified by flow cytometry and viability quantified using a fluorescence plate reader. Representative histograms for MCT1 and MCT4 protein are provided. (A) Paired t test, (B) one- or (D) two-way ANOVA with Tukey multiple comparisons test (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001, ns = not significant).
Figure S2 from Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
Authors: Monteith Andrew J. , Ramsey Haley E. , Silver Alexander J. , Brown Donovan , Greenwood Dalton , Smith Brianna N. , Wise Ashley D. , Liu Juan , Olmstead Sarah D. , Watke Jackson , Arrate Maria P. , Gorska Agnieszka E. , Fuller Londa , Locasale Jason W. , Stubbs Matthew C. , Rathmell Jeffrey C. , Savona Michael R.
Published: April 2024

Figure S2: Maximal respiration in MOLM-13 cells is unaffected by the addition of BETi and/or lactate utilization inhibitors. MV-4-11 and MOLM-13 cells were cultured for 72 hr with indicated treatments (BETi = 0.15 µM; AZD3965, UK5099, oxamate = 0.1 µM), subjected to a mitochondrial stress test, and oxygen consumption rates (OCR) quantified by extracellular flux analysis. Maximal respiration was quantified where each point represents individual experiments (n=3). Two-way ANOVA with Sidak’s multiple comparisons test (*P ≤ 0.05, ns = not significant).
Figure S7 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Authors: Goldberg Lior , Haas Eric R. , Urak Ryan , Vyas Vibhuti , Pathak Khyatiben V. , Garcia-Mansfield Krystine , Pirrotte Patrick , Singhal Jyotsana , Figarola James L. , Aldoss Ibrahim , Forman Stephen J. , Wang Xiuli
Published: April 2024

Figure S7. Growth curve of CAR T cells produced in RPMI or CSF; n = 7 patients.
Figure S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Authors: Goldberg Lior , Haas Eric R. , Urak Ryan , Vyas Vibhuti , Pathak Khyatiben V. , Garcia-Mansfield Krystine , Pirrotte Patrick , Singhal Jyotsana , Figarola James L. , Aldoss Ibrahim , Forman Stephen J. , Wang Xiuli
Published: April 2024

Figure S4. Patients’ CD8+ CAR T cells spatiotemporal metabolic state.
Figure S3 from Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs
Authors: Lumeau Audrey , Bery Nicolas , Francès Audrey , Gayral Marion , Labrousse Guillaume , Ribeyre Cyril , Lopez Charlene , Nevot Adele , El Kaoutari Abdessamad , Hanoun Naima , Sarot Emeline , Perrier Marion , Pont Frederic , Cerapio Juan-Pablo , Fournié Jean-Jacques , Lopez Frederic , Madrid-Mencia Miguel , Pancaldi Vera , Pillaire Marie-Jeanne , Bergoglio Valerie , Torrisani Jerome , Dusetti Nelson , Hoffmann Jean-Sebastien , Buscail Louis , Lutzmann Malik , Cordelier Pierre
Published: April 2024

Figure S3
Figure S2 from Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs
Authors: Lumeau Audrey , Bery Nicolas , Francès Audrey , Gayral Marion , Labrousse Guillaume , Ribeyre Cyril , Lopez Charlene , Nevot Adele , El Kaoutari Abdessamad , Hanoun Naima , Sarot Emeline , Perrier Marion , Pont Frederic , Cerapio Juan-Pablo , Fournié Jean-Jacques , Lopez Frederic , Madrid-Mencia Miguel , Pancaldi Vera , Pillaire Marie-Jeanne , Bergoglio Valerie , Torrisani Jerome , Dusetti Nelson , Hoffmann Jean-Sebastien , Buscail Louis , Lutzmann Malik , Cordelier Pierre
Published: April 2024

Figure S2
Data from Integrating AI-Powered Digital Pathology and Imaging Mass Cytometry Identifies Key Classifiers of Tumor Cells, Stroma, and Immune Cells in Non–Small Cell Lung Cancer
Authors: Rigamonti Alessandra , Viatore Marika , Polidori Rebecca , Rahal Daoud , Erreni Marco , Fumagalli Maria Rita , Zanini Damiano , Doni Andrea , Putignano Anna Rita , Bossi Paola , Voulaz Emanuele , Alloisio Marco , Rossi Sabrina , Zucali Paolo Andrea , Santoro Armando , Balzano Vittoria , Nisticò Paola , Feuerhake Friedrich , Mantovani Alberto , Locati Massimo , Marchesi Federica
Published: April 2024

Abstract
Artificial intelligence (AI)–powered approaches are becoming increasingly used as histopathologic tools to extract subvisual features and improve diagnostic workflows. On the other hand, hi-plex approaches are widely adopted to analyze the immune ecosystem in tumor specimens. Here, we aimed at combining AI-aided histopathology and imaging mass cytometry (IMC) to analyze the ecosystem of non–small cell lung cancer (NSCLC). An AI-based approach was used on hematoxylin and eosin (H&E) sections from 158 NSCLC specimens to accurately identify tumor cells, both adenocarcinoma and squamous carcinoma cells, and to generate a classifier of tumor cell spatial clustering. Consecutive tissue sections were stained with metal-labeled antibodies and processed through the IMC workflow, allowing quantitative detection of 24 markers related to tumor cells, tissue architecture, CD45+ myeloid and lymphoid cells, and immune activation. IMC identified 11 macrophage clusters that mainly localized in the stroma, except for S100A8+ cells, which infiltrated tumor nests. T cells were preferentially localized in peritumor areas or in tumor nests, the latter being associated with better prognosis, and they were more abundant in highly clustered tumors. Integrated tumor and immune classifiers were validated as prognostic on whole slides. In conclusion, integration of AI-powered H&E and multiparametric IMC allows investigation of spatial patterns and reveals tissue relevant features with clinical relevance.
Significance:
Leveraging artificial intelligence–powered H&E analysis integrated with hi-plex imaging mass cytometry provides insights into the tumor ecosystem and can translate tumor features into classifiers to predict prognosis, genotype, and therapy response.
Data from Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia
Authors: Raucci Franca , Vernieri Claudio , Di Tano Maira , Ligorio Francesca , Blaževitš Olga , Lazzeri Samuel , Shmahala Anastasiya , Fragale Giuseppe , Salvadori Giulia , Varano Gabriele , Casola Stefano , Buono Roberta , Visco Euplio , de Braud Filippo , Longo Valter D.
Published: April 2024

Abstract
Cyclic fasting–mimicking diet (FMD) is an experimental nutritional intervention with potent antitumor activity in preclinical models of solid malignancies. FMD cycles are also safe and active metabolically and immunologically in cancer patients. Here, we reported on the outcome of FMD cycles in two patients with chronic lymphocytic leukemia (CLL) and investigated the effects of fasting and FMD cycles in preclinical CLL models. Fasting-mimicking conditions in murine CLL models had mild cytotoxic effects, which resulted in apoptosis activation mediated in part by lowered insulin and IGF1 concentrations. In CLL cells, fasting conditions promoted an increase in proteasome activity that served as a starvation escape pathway. Pharmacologic inhibition of this escape mechanism with the proteasome inhibitor bortezomib resulted in a strong enhancement of the proapoptotic effects of starvation conditions in vitro. In mouse CLL models, combining cyclic fasting/FMD with bortezomib and rituximab, an anti-CD20 antibody, delayed CLL progression and resulted in significant prolongation of mouse survival. Overall, the effect of proteasome inhibition in combination with FMD cycles in promoting CLL death supports the targeting of starvation escape pathways as an effective treatment strategy that should be tested in clinical trials.
Significance:
Chronic lymphocytic leukemia cells resist fasting-mimicking diet by inducing proteasome activation to escape starvation, which can be targeted using proteasome inhibition by bortezomib treatment to impede leukemia progression and prolong survival.
Data from Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs
Authors: Lumeau Audrey , Bery Nicolas , Francès Audrey , Gayral Marion , Labrousse Guillaume , Ribeyre Cyril , Lopez Charlene , Nevot Adele , El Kaoutari Abdessamad , Hanoun Naima , Sarot Emeline , Perrier Marion , Pont Frederic , Cerapio Juan-Pablo , Fournié Jean-Jacques , Lopez Frederic , Madrid-Mencia Miguel , Pancaldi Vera , Pillaire Marie-Jeanne , Bergoglio Valerie , Torrisani Jerome , Dusetti Nelson , Hoffmann Jean-Sebastien , Buscail Louis , Lutzmann Malik , Cordelier Pierre
Published: April 2024

Abstract
Cytidine deaminase (CDA) functions in the pyrimidine salvage pathway for DNA and RNA syntheses and has been shown to protect cancer cells from deoxycytidine-based chemotherapies. In this study, we observed that CDA was overexpressed in pancreatic adenocarcinoma from patients at baseline and was essential for experimental tumor growth. Mechanistic investigations revealed that CDA localized to replication forks where it increased replication speed, improved replication fork restart efficiency, reduced endogenous replication stress, minimized DNA breaks, and regulated genetic stability during DNA replication. In cellular pancreatic cancer models, high CDA expression correlated with resistance to DNA-damaging agents. Silencing CDA in patient-derived primary cultures in vitro and in orthotopic xenografts in vivo increased replication stress and sensitized pancreatic adenocarcinoma cells to oxaliplatin. This study sheds light on the role of CDA in pancreatic adenocarcinoma, offering insights into how this tumor type modulates replication stress. These findings suggest that CDA expression could potentially predict therapeutic efficacy and that targeting CDA induces intolerable levels of replication stress in cancer cells, particularly when combined with DNA-targeted therapies.
Significance:
Cytidine deaminase reduces replication stress and regulates DNA replication to confer resistance to DNA-damaging drugs in pancreatic cancer, unveiling a molecular vulnerability that could enhance treatment response.
Supplementary Table S1 from Combined Vorinostat and Chloroquine Inhibit Sodium–Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo
Authors: Read Martin L. , Brookes Katie , Zha Ling , Manivannan Selvambigai , Kim Jana , Kocbiyik Merve , Fletcher Alice , Gorvin Caroline M. , Firth George , Fruhwirth Gilbert O. , Nicola Juan P. , Jhiang Sissy , Ringel Matthew D. , Campbell Moray J. , Sunassee Kavitha , Blower Philip J. , Boelaert Kristien , Nieto Hannah R. , Smith Vicki E. , McCabe Christopher J.
Published: April 2024

Supplementary Table S1
Supplementary Figure S8 from Combined Vorinostat and Chloroquine Inhibit Sodium–Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo
Authors: Read Martin L. , Brookes Katie , Zha Ling , Manivannan Selvambigai , Kim Jana , Kocbiyik Merve , Fletcher Alice , Gorvin Caroline M. , Firth George , Fruhwirth Gilbert O. , Nicola Juan P. , Jhiang Sissy , Ringel Matthew D. , Campbell Moray J. , Sunassee Kavitha , Blower Philip J. , Boelaert Kristien , Nieto Hannah R. , Smith Vicki E. , McCabe Christopher J.
Published: April 2024

Supplementary Figure S8
Supplementary Table S4 from Enhancer of Zeste Homolog 2 Inhibitor SHR2554 in Relapsed or Refractory Peripheral T-cell Lymphoma: Data from the First-in-Human Phase I Study
Authors: Song Yuqin , Jin Zhengming , Li Zhi-Ming , Liu Yanyan , Li Lanfang , He Chuan , Su Hang , Zhou Hui , Li Kunyan , Hao Siguo , Zuo Xuelan , Wu Jianyuan , Li Dengju , Wu Meng , Sun Xiuhua , Qi Junyuan , Cai Zhen , Li Zengjun , Li Yijing , Huang Yanhua , Shen Jie , Xiao Zhenyu , Zhu Jun
Published: April 2024

Supplementary Table S4. Anti-tumor activity in efficacy evaluable set.
Supplementary Table S3 from Enhancer of Zeste Homolog 2 Inhibitor SHR2554 in Relapsed or Refractory Peripheral T-cell Lymphoma: Data from the First-in-Human Phase I Study
Authors: Song Yuqin , Jin Zhengming , Li Zhi-Ming , Liu Yanyan , Li Lanfang , He Chuan , Su Hang , Zhou Hui , Li Kunyan , Hao Siguo , Zuo Xuelan , Wu Jianyuan , Li Dengju , Wu Meng , Sun Xiuhua , Qi Junyuan , Cai Zhen , Li Zengjun , Li Yijing , Huang Yanhua , Shen Jie , Xiao Zhenyu , Zhu Jun
Published: April 2024

Supplementary Table S3. Anti-tumor activity by lines of previous systemic regimens (intention-to-treat set).
Supplementary Method 1 from Enhancer of Zeste Homolog 2 Inhibitor SHR2554 in Relapsed or Refractory Peripheral T-cell Lymphoma: Data from the First-in-Human Phase I Study
Authors: Song Yuqin , Jin Zhengming , Li Zhi-Ming , Liu Yanyan , Li Lanfang , He Chuan , Su Hang , Zhou Hui , Li Kunyan , Hao Siguo , Zuo Xuelan , Wu Jianyuan , Li Dengju , Wu Meng , Sun Xiuhua , Qi Junyuan , Cai Zhen , Li Zengjun , Li Yijing , Huang Yanhua , Shen Jie , Xiao Zhenyu , Zhu Jun
Published: April 2024

Supplementary Method. Inclusion and exclusion criteria of the dose-escalation, dose-expansion, and clinical expansion part I of this phase 1 study.
Supplementary Figure S6 from Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library
Authors: Singh Abhay K. , Lewis Calvin D. , Boas Cristian A.W.V. , Diebolder Philipp , Jethva Prashant N. , Rhee Aaron , Song Jong Hee , Goo Young Ah , Li Shunqian , Nickels Michael L. , Liu Yongjian , Rogers Buck E. , Kapoor Vaishali , Hallahan Dennis E.
Published: April 2024

Supplementary Figure 6. Flow cytometry evaluation of the purified anti-TIP1 antibodies on H460 (A) and A549 (B) cells. The percentage of anti-TIP1+ vs. antibody concentration was plotted in GraphPad Prism software using One Site-specific binding model. The table below represents the Kd values. C. Immunohistochemistry shows intense TIP1 staining in the human patient-derived xenograft tissue.
Supplementary Table S4 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer
Authors: Earland Noah , Semenkovich Nicholas P. , Ramirez Ricardo J. , Gerndt Sophie P. , Harris Peter K. , Gu Zhuosheng , Hearn Andrew I. , Inkman Matthew , Szymanski Jeffrey J. , Whitfield Damion , Wahle Benjamin M. , Xu Zhongping , Chen Kevin , Alahi Irfan , Ni Gabris , Chen Andrew , Winckler Wendy , Zhang Jin , Chaudhuri Aadel A. , Zevallos Jose P.
Published: April 2024

Supplementary Table S4. Tumor-informed variant allele frequencies and depths in lymph samples