bluuebunny/crossref_metadata_2025 huggingface dataset:
The State of Art and Prospects Development for the Intelligent Information Technologies. To the 25th Anniversary of the International Research and Training Centre for Information Technologies and Systems
Authors:   International Research and Training Centre of Information Technologies and Systems of the NAS and MES of Ukraine, Gritsenko Volodymyr I.
Published: July 2022

Introduction. The International Research and Training Center was created 25 years ago as part of the Department of Informatics of the National Academy of Sciences and the Ministry of Science and Education of Ukraine in 1997. The principal lines of investigation of the International Center are information technologies and their applications. Information technology is a set of software and hardware tools that has effect data in order to obtain an end product that has the properties and capabilities to generate new knowledge and study complex phenomena and processes based on it. The purpose of the article is to demonstrate the achievements of the International Centre over the 25 years, to show the current situation and prospects of its developments. Methods. The formation and development of the general theory of intelligent information technologies and their use in pattern recognition, complex investigation of the text and speech information, including the semantic processing, evaluation, understanding, reforming, reliability and fast search, are being carried out at the International Center. The priority areas of intellectualization of the digital economy, technologies for data mining, choice and decision-making, models of interaction between digitalization and informatization of society are being explored. Conceptual models of digital medicine are being developed. Results and Conclusion. The International Center has become a leading organization for the development of informatics and new intelligent information technologies and systems. His work is highly appreciated in the country and abroad. It should be noted the achievements of leading scientific schools, headed by prominent Ukrainian scientists, employees of the International Center: Academicians V.I. Skurikhin, O.H. Ivakhnenko, M.M. Amosov and O.O. Bakaev. Research and development programs and plans are innovative and focused on solving scientific and technological problems of intellectualization and digital transformation. These problems of global importance form the basis of the short-term program as well as the concept of development of the activities of the International Center.
Analysis of the growth, productivity and nutritional content of jarak towo variety cassava at various fertilizers and altitudes in Karanganyar Regency, Indonesia
Authors: Irianto Heru , Mujiyo Mujiyo , Ningsih Hardian , Qonita Rade Rara Aulia , Riptanti Erlyna Wida
Published: July 2022

Pengembangan singkong Jarak Towo meningkatkan ketersediaan bahan baku olahan pangan dan pendapatan petani. Hal ini karena keunggulan rasa dan tekstur halus dengan harga mencapai 3 sampai 4 kali lipat dari varietas lain. Sebagai bahan baku industri pengolahan pangan, harus didukung dengan kandungan gizi yang berkualitas. Penelitian ini bertujuan untuk mengetahui produktivitas, parameter pertumbuhan, kandungan gizi singkong Jarak Towo dengan perlakuan dosis pupuk P dan K serta ketinggian tempat yang berbeda. Penelitian ini menggunakan percobaan rancangan acak kelompok lengkap dengan faktorial kombinasi dosis pupuk P dan K. Dosis pupuk P tiga level berupa SP36 yaitu 0 kg ha-1, 100 kg ha-1, dan 200 kg ha-1, sedangkan dosis pupuk K berupa KCl tiga level yaitu 0 kg ha-1, 150 kg ha-1, 300 kg ha-1 sehingga diperoleh sembilan kombinasi perlakuan yang diulang di tiga lokasi yaitu Desa Kemuning, Sepanjang, dan Wonorejo pada ketinggian 700 mdpl, 927 mdpl, and 1034 mdpl. Hasil penelitian menunjukkan bahwa singkong Jarak Towo yang dibudidayakan di Desa Kemuning memiliki kadar air dan lemak tertinggi 54,28 ± 2,76% dan 0,78 ± 0,21%. Kandungan karbohidrat dan protein tertinggi diperoleh di Desa Wonorejo 15,74 ± 4,25% dan 2,42 ± 0,23%. Perlakuan pupuk P dan K tidak berpengaruh signifikan terhadap parameter pertumbuhan, produktivitas dan nutrisi dalam singkong Jarak Towo.ABSTRACTThe development of Jarak Towo cassava increases the availability of processed food raw materials and farmers' income. This is because of the superiority of taste and smooth texture with prices reaching 3 to 4 times that of other varieties. As a raw material for the food processing industry, it must be supported by quality nutritional content. This study aimed to determine productivity, the growth parameters, nutritional content of Jarak Towo cassava with different doses of P and K fertilizers and altitudes. This research used a completely randomized block design trial with a factorial combination of P and K fertilizer doses. The dose of P fertilizer at three levels in the form of SP36 was 0 kg ha-1, 100 kg ha-1, and 200kg ha-1, while the dose of K fertilizer in the form of KCl 3 levels was 0 kg ha-1, 150 kg ha-1, 300 kg ha-1 in order to obtain nine treatment combinations repeated in three locations, namely Kemuning, Sepanjang, and Wonorejo Villages at an altitude of 700 masl, 927 masl, and 1034 masl. The results showed that Jarak Towo cassava cultivated in Kemuning Village had the highest water content and fat content of 54.28 ± 2.76% and 0.78 ± 0.21%. The highest carbohydrate and protein content were obtained in Wonorejo Village 15.74 ± 4.25% and 2.42 ± 0.23%. The treatment of P and K fertilizers had no significant effect on the growth parameters, productivity and nutrition in Jarak Towo cassava.
Immobilisasi Nanopartikel Tembaga (Cu) dan Ekstrak Kulit Buah Pinang (Areca catechu) pada Kain Katun
Authors: Aini Qurrata , Nuralang Nuralang , Pradina Armitha Dea , Yamin Muhammad Arief , Amanda Amanda , Gusti Diah Riski
Published: August 2022

Nanopartikel tembaga (Cu) merupakan salah satu nanopartikel logam yang memberikan banyak manfaat dan menjadi perhatian dikarenakan sifat fisik dan kimianya menarik. Penelitian ini bertujuan untuk mensintesis nanopartikel Cu dengan menggunakan bioreduktor berupa ekstrak limbah kulit buah pinang yang juga bertindak sebagai pewarna alami untuk menghasilkan kain katun yang diharapkan dapat bertindak sebagai agen antibakteri. Penggunaan pewarna alami ini merupakan salah satu cara pemanfaatan limbah dari tanaman pinang yang merupakan komoditas lokal dari Provinsi Jambi yang selama ini belum dimanfaatkan secara optimal. Pada proses sintesis nanopartikel Cu yang dilakukan, metode yang digunakan adalah reduksi kimia. Metode reduksi kimia sering digunakan untuk mensintesis logam menjadi nanopartikel. Penggunaan ekstrak tanaman dapat menjadi sebuah bioreduktor yang baik untuk mendapatkan sintesis nanopartikel dengan ukuran yang kecil. Hasil XRD menunjukkan sintesis ekstrak kulit buah pinang dengan Cu menghasilkan CuO dan Cu2O yang merupakan nanopartikel Cu. Sedangkan hasil SEM memperlihatkan kain katun telah berhasil dilapisi oleh nanopartikel Cu.
Kajian Farmakoinformatika Senyawa Brazilin dan 3-O-Methyl Brazilin Caesalpinia sappan Sebagai Terapi Demam Berdarah Dengue
Authors: Sari Dewi Ratih Tirto , Yusuf Heny , Sifaiyah Laily , Camelia Nur Dina , Bare Yohanes
Published: August 2022

Demam berdarah Dengue (DBD) merupakan penyakit tropis yang diakibatkan oleh gigitan nyamuk yang terinfeksi oleh virus DENV. Beberapa tanaman herbal dapat digunakan untuk mengatasi demam berdarah baik upaya preventif maupun kuratif. Kayu secang merupakan salah satu tanaman herbal kayu yang memiliki berbagai aktivitas biologis, utamanya sebagai immunomodulator dan antivirus. Penelitian ini bertujuan untuk mengidentifikasi aktivitas brazilin dan 3-O-methyl brazilin sebagai obat terapi demam berdarah melalui kajian komputasi. Pendekatan molecular docking digunakan dalam studi penelitian ini. Senyawa brazilin dan 3-O-methyl brazilin diunduh dari database PubChem dan diinteraksikan dengan protein non- structural-5 (NS-5) yang didapatkan dari database PDB. Pemodelan docking dilakukan dengan Molegro virtual Docker versi 5.0 dan dianalisis dengan PyMol 2.2 dan Discovery studio versi 21.1.1. Hasil interaksi menunjukkan bahwa brazilin dan 3-O-methyl brazilin berikatan dengan protein NS-5 di sisi aktif guanosine triphosphate dan daerah RNA dependent RNA polymerase (RdRP). Pengikatan kedua senyawa aktif ini menyebabkan tidak terjadinya replikasi virus DENV pada sel inang dan berpotensi sebagai penghambat infeksi DENV. Berdasarkan analisis in silico, disimpulkan bahwa brazilin dan 3-O-methyl brazilin berpotensi sebagai agen terapi demam berdarah, studi in vitro perlu dilakukan untuk pembuktian lebih lanjut.
Environmental Paradoxes
Authors: Costa Thiago
Published: August 2022

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Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney
Authors: Drake Keri A. , Chaney Christopher , Patel Mohita , Das Amrita , Bittencourt Julia , Cohn Martin , Carroll Thomas J.
Published: August 2022

Significance Statement

Embryonic renal interstitial cells give rise to multiple cell types in the adult, including fibroblasts, myofibroblasts, mural cells, and smooth muscle. How the different cell types arise from a multipotent progenitor is unknown. In this study, the authors identified a subpopulation of stromal cells in mouse embryonic kidneys with enriched activity in the transcriptional regulators YAP and TAZ, and show that YAP/TAZ and the transcriptional regulator SRF have independent and codependent roles in the specification of unique subsets of interstitial cells. These findings offer insights into the role of the interstitium in kidney development and may inform efforts aimed at regenerating renal tissue and may aid efforts to understand the drivers of kidney fibrosis.

Background

The embryonic renal stroma consists of multiple molecularly distinct cell subpopulations, the functional significance of which is largely unknown. Previous work has demonstrated that the transcription factors YAP and TAZ play roles in the development and morphogenesis of the nephrons, collecting ducts, and nephron progenitor cells.

Methods

In embryonic mouse kidneys, we identified a subpopulation of stromal cells with enriched activity in YAP and TAZ. To evaluate the function of these cell types, we genetically ablated both Yap and Taz from the stromal progenitor population and examined how gene activity and development of YAP/TAZ mutant kidneys are affected over a developmental time course.

Results

We found that YAP and TAZ are active in a subset of renal interstitium and that stromal-specific coablation of YAP/TAZ disrupts cortical fibroblast, pericyte, and myofibroblast development, with secondary effects on peritubular capillary differentiation. We also demonstrated that the transcription factor SRF cooperates with YAP/TAZ to drive expression of at least a subset of renal myofibroblast target genes and to specify myofibroblasts but not cortical fibroblasts or pericytes.

Conclusions

These findings reveal a critical role for YAP/TAZ in specific embryonic stromal cells and suggest that interaction with cofactors, such as SRF, influence the expression of cell type–specific target genes, thus driving stromal heterogeneity. Further, this work reveals functional roles for renal stroma heterogeneity in creating unique microenvironments that influence the differentiation and maintenance of the renal parenchyma.
Psicología y descolonialidad: saberes para curar en palenques y quilombos (Colombia-Brasil)
Authors:   Universidad Cooperativa de Colombia, Parra-Valencia Liliana , Galindo Dolores ,   Universidad Federal de Mato Grosso, Fernandes Saulo Luders ,   Universidad Federal de Alagoas
Published: August 2022

El presente se trata de un texto producto de investigación, que aprehende otras realidades y modos de vida, al ampliar las posibilidades en la construcción de conocimiento. Desde una mirada comprometida con las apuestas de las comunidades palenqueras, afrodescendientes y quilombolas, con miras a contribuir al proceso de descolonizar la Psicología, aportamos a los debates étnico-raciales, al identificar formas otras de hacer investigación y construir conocimiento ante problemáticas sociales como el racismo, la discriminación, el blanqueamiento, el sexismo y el desarraigo de la sabiduría. Ante la preeminencia de discursos hegemónicos de la ciencia, y a contrapelo de las lógicas de blanqueamiento del canon psicosocial, nos comprometemos con la articulación y visibilización de autoras y autores afrodescendientes en nuestros diálogos teóricos. Presentamos un recuento de aportes descoloniales en el campo psicológico, reflexionamos sobre la historicidad de resistencia afrodiaspórica de pueblos africanos sometidos a la esclavización colonial, y planteamos una propuesta interseccional y multidimensional para pensar los modos de vida en Colombia y Brasil. Nos acercamos a las particularidades de los palenques en Colombia, las comunidades afrodescendientes de San Cristóbal y San Basilio de Palenque en Montes de María, visibilizando así los modos de vida y las dimensiones histórico-culturales y espirituales. También nos aproximamos a los quilombos en Brasil como formaciones sociopolíticas quilombolas del agreste en la región semiárida de Alagoas; en particular, a las comunidades Pau D’arco y Tabacaria. Sobre estas cuatro comunidades compartimos los análisis de los mapeos comunitarios de saberes para curar, a partir del trabajo de campo en Colombia y Brasil. Este esfuerzo se suma a la reflexión y visibilización de las historias poco o nada narradas (Curiel, 2009), así como a las cosmogonías y las filosofías otras, en particular las africanas, sin desconocer las indígenas y europeas, que nos han nutrido por décadas. Este conjunto de reflexiones nos permite aportar a la descolonización de la Psicología.
EVOLUTION OF BUSINESS MODELS DURING THE COVID-19 PANDEMIC
Authors: Teker Suat , Orendil Emre
Published: August 2022

Purpose - The purpose of this study is to propose a comprehensive definition for business models, reviews and summarizes the findings of a previous work by Guckenbiehl and Corral de Zubielqui (2022) about how business models have evolved by providing insights from reshaped businesses during the COVID-19 pandemic.
Methodology - In this study, an extensive literature review is followed to learn about definition of business models and how business model have been adapted or even innovated during the times of the COVID-19 pandemic.
Findings - Construction of a well-planned business model is a requirement for an organization to reach success. In the times of disruptive events, business models go through adaptive or innovative changes which is a necessity for survival and further success. It is observed that organizations generate different responses to crises (e.g., the COVID-19 pandemic) in means of business model changes. The understanding of these differences is facilitated by the aforementioned work through grouping organizations in six different clusters.
Conclusion - The structure of a business model prior to the COVID-19 pandemic was also one of the determinants of a business’s response to the pandemic. Businesses either made no changes in their business models, or made notable innovations, or little adaptations in response to the disruptive environment.

Keywords: Business models, adaptation, innovation, COVID-19, pandemic.
JEL Codes: M10, M15, M20
TYPOLOGY OF INNOVATION ECOSYSTEMS UNIVERSITY-BASED INNOVATION ECOSYSTEMS ENTREPRENEURS IN THE UNITED ARAB EMIRATES
Authors: Alkhanbouli Ayman Rashed
Published: August 2022

Purpose- This paper explores the typology of innovation ecosystems obtained from the literature review which university-based innovation ecosystems in the United Arab Emirates (UAE) universities on the entrepreneurial subdivision of the innovation ecosystem and terms it an entrepreneurial ecosystem.
Methodology- The aims of this study is qualitative in nature, while reflecting its exploratory nature and the absence of any previous work on university Typology of innovation in the UAE. A list of all UAE universities from the Commission for Academic Accreditation (CAA) will be used as primary research. Secondary sources and used as a sampling frame. The sampling procedure involved contacting the universities or colleges.
Findings- The Centre of Excellence for Applied Research and Training (CERT) at Higher Colleges of Technology (HCT) Established in 1996 the first center to adopt entrepreneurial initiatives. The UAEU Science and Innovation Park (UAEU-SIP) and Start AD, NYU Abu Dhabi both established in 2016 as the first concepts of innovation and incubator centers in the UAE universities. The UAE Government and Local government are the biggest supporters of universities, and with limited support from the private sector. Due to the early stage of those incubators and centers, with building a skilled workforce with entrepreneurial mindsets, the outcomes of incubated startups are expected to emerge after some time.
Conclusion- This study focused only on universities located in the UAE which it's an emerging country. This study focused on university incubators or Innovation Centers only as introduced above more research is required on university-based innovation ecosystems' reach and strategic context.

Keywords: Entrepreneurial, Ecosystem, Typology of innovation,UAE, University-based innovation
JEL Codes: O30, O31
WHY INVEST GLOBALLY IN FAMILY FIRMS
Authors: Teker Suat , Teker Dilek , Demirel Esin
Published: August 2022

Purpose- Family firms have a significant economic role in many countries around the world. Family firms make a significant contribution to World GDP and employ a significant part of the global workforce. The scope of this study covers the top 25 largest and publicly owned family firms announced by Ernst & Young’s 2021 Report for Family Businesses. These 25 family firms generated more than 2 trillion USD and employed 6.5 million in 2021. This empirical study aims to investigate the excess stock returns of family firms over the related country stock market indexes and the risks (betas) for the period between 2002 and 2021. Therefore, this study explores the question of “why invest globally in family firms and whether this investment pays off with higher returns and less risk”.
Methodology- The World's Largest Family Companies" list is published every other two years by Ernst & Young and the last issue was published in 2021. The world’s largest family companies list includes both private and publicly owned family firms. This study employs 25 world’s largest family firms after the exclusion of privately held family firms. The monthly stock prices of family firms, related country stock market index values, and global stock market index values are obtained from Refinitiv Eikon (Reuters) database for the period between 2002 and 2021 (20 years). Therefore, a total of 9120 observations are extracted for this empirical study. Eviews-10 is utilized for all econometric analysis.
Findings- This study investigates whether an individual or intuitional investor can earn more than the average return of the stock markets by investing in publicly traded family firms meanwhile exposing less risk. The empricial results reveal that Maersek shows 354% (beta of 1.18) excess return over the 20 year period and followed by Hanwha with a 335% (beta of 0.69) excess return. Later, all family firms are grouped based on country of headquartered and 7 country portfolios are formed. The highest excess returns are provided by South Koean portfolio (an excess return of 189% with a beta of 0.83) and it is followed by Indian portfolio (an excess return of 174% with a beta of 1.0). Finaly, a best performer portfolio is formed by the 10 family firms with highest excess returns. This portfolio provides a 131% excess return with a beta of 1.18 over 20-year peirod.
Conclusion- The empirical results show that the individual firm returns and portfolio returns of family firms are higher than the returns of the stock market indexes. Those who invest in family businesses get higher returns with less risk. Investments in publicly traded family firms pay off.

Keywords: Family firms, global investment, return, risk, stock markets.
JEL Codes: G10, G11, G15
DIGITAL PAYMENT SYSTEMS: A FUTURE OUTLOOK
Authors: Teker Suat , Teker Dilek , Orman Irmak
Published: August 2022

Purpose- This study examines the development of digital payment systems with the evolution of communication technologies, financial institutions and fintech companies. Also, this study analyzes the expected effects of developing payment systems and fintech applications.
Methodology- The study defines different types of digital payment systems, compares general characteristics of digital payments, provides a timeline of developments for digital payment systems and compares most used digital payment applications.
Findings- The payments market is changing in line with consumer behavior.
Cashless economies, mobile banking, instant payments, digital commerce, and the growing impact of regulatory agencies are a few trends affecting the payments market. Contactless payments also make the payment process easier and more convenient for consumers who benefit from shorter lines, cash-on-hand issue elimination, and faster moving queues.The Asia-Pacific region is anticipated to witness significant growth in the market such as China and India. Digital and mobile wallets account for 58% of regional e-commerce payments in the region and are expected to reach 68.2% by 2023. The e-commerce sector is witnessing a spike in demand as consumers order essential items such as food and clothes through e-commerce websites, where most consumers prefer the digital mode of payment.Transition towards the cashless economy, emergence of new online financial institutions, a decentralized monetary governance with the adoption of blockchain and cryptocurrencies are envisioned. Advancements in payment technologies as well as digital payment systems adoption will create momentum and create further investments towards digitalization of monetary exchange.
Conclusion- It is concluded that evolution of digital payment systems will extend convenience, return, convergence, cross-border and time-limitless transaction. Inclusion of the unbanked is expected to drive growth and create new opportunities. There is a clear transition towards a cashless economy with the increasing adoption of digital payment systems by all spenders. Speed, privacy, convenience, security and decentralization will mean a wider inclusion for all global citizens; even including some unbanked population. Decentralization and blockchain will mean a blur in distribution of wealth, some money leaving the traditional banking systems. Digital payment systems provide a wide range of transaction options to its users; swiped credit cards, electronic checks, mobile wallets and contactless payment. By 2050s, the circulation of physical money is expected to vanish, leaving its place to virtual currencies changed on digital platforms.

Keywords: Digital payments, online transactions, digital wallets, e-payment, cashless economy
JEL Codes: M21, O33, O42
Chaos, resistant and pseudoresistant hypertension “Thousands of butterflies in the BP control system”
Authors: Juan Carlos Yugar-Toledo , Nelson Dinamarco , Bruno Rodrigues , Heitor Moreno
Published: August 2022

In Cardiology, we classify hypertensive patients as resistant to treatment, pseudo-resistant, or hyperreactivity subjects, including the WCH (white-coat or masked hypertension). Compliance is another cause of failure in antihypertensive therapy. Hypertension is a complex clinical syndrome and many variables that interfere in BP depend on “The Theory of Chaos” and are not considered. We do not know how many variations the Chaos on BP levels can be. Still, as we have around 30% of “uncontrolled” patients, the Chaos and effects on BP regulation as taking part in this high rates of “uncontrolled” subjects. Chaos is a complicated issue to study, but multi-professional efforts must keep the attention to this relevant “cause” of hypertension. Finally, Chaos theory is well known and accepted in Maths, Economy, Philosophy, Meteorology, Ecology, and other areas of knowledge, but not in the Health area. Crescent attention to Chaos may help better understand some mechanisms and clinical expression of Chaos in pseudo-resistant hypertension and correlated hypertensive syndromes.
Potential assessment of renewable energy resources and their power plant capacities in Iran
Authors: Mehrzad Khazaee , Rahim Zahedi , Reza Faryadras , Abolfazl Ahmadi
Published: August 2022

Today, most developed and developing countries utilize renewable energy to meet their needs. The use of renewable energy prevents environmental pollution. A concern of the governments is to deal with environmental pollution. Iran as a major oil-producing country has increasingly paid attention to non-fossil energy resources, in particular renewable energy sources for its longer-term energy plans. In this paper, the types of renewable energy used in electricity generation in Iran have been studied. Studies show that during the last 20 years, 1.5% of the amount of electricity produced in Iran is supplied by renewable energy. Iran also has a much greater potential for utilizing renewable energy. By 2020, Iran has a potential of 42000 MW use of renewable energies. However, the capacity of renewable power stations constructed in Iran is 800 MW. Different regions of Iran have high wind, solar and geothermal energy potential, which has not been used enough to meet electricity needs.
Discovery proteomic (DIA) LC-MS/MS data acquisition and analysis v1
Authors: Chen Yan
Published: August 2022

This protocol details steps in discovery proteomic data-independent acquisition with a standard-flow UHPLC-Obitrap system and a subsequent DIA-NN library-free database search. The data acquisition method was adapted from González Fernández-Niño, S. M., et al. "Standard flow liquid chromatography for shotgun proteomics in bioenergy research."Frontiers in bioengineering and biotechnology, 3 (2015): 44.
Smartphone apps as a motivating tool in English language learning
Authors: Annamalai Nagaletchimee , Kabilan Muhammad Kamarul , Soundrarajan Deepa
Published: August 2022

Since smartphones are getting cheaper, sophisticated, and multifunctional, there are opportunities for learners to engage in more meaningful English language learning. This study employs a mixed-method research design, with the purpose of identifying the use of English language apps outside the classroom and depicting students’ English language apps use behaviour i.e. motivation from the Self-Determination Theory (SDT). The findings show that students use the apps related to grammar the most and followed by English apps related to speaking, reading and, vocabulary. Findings also reveal students in this study display three types of motivation from the perspective of SDT i.e. autonomy, competence, and relatedness. Based on the findings, a model of Pedagogical Considerations of Using Smartphone for English Language Learning (PCUSELL) is suggested. As a conclusion, the authors suggests that educators in higher educational institution educators should consider the potential of smartphone English apps in their teaching and learning activities, particularly in this new normal of teaching and learning i.e. epoch of the COVID-19 pandemic.
Identification of Potential Ligands of the Main Protease of Coronavirus SARS-CoV-2 (2019-nCoV) Using Multimodal Generative Neural-Networks
Authors:   Department of Chemistry, University of Karachi, Karachi, Pakistan, Zia Syeda Rehana
Published: July 2022

The recent outbreak of coronavirus disease 2019 (COVID-19) is posing a global threat to human population. The pandemic caused by novel coronavirus (2019-nCoV), also called as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); first emerged in Wuhan city, Hubei province of China in December 2019. The rapid human to human transmission has caused the contagion to spread world-wide affecting 244,385,444 (244.4 million) people globally causing 4,961,489 (5 million) fatalities dated by 27 October 2021. At present, 6,697,607,393 (6.7 billion) vaccine doses have been administered dated by 27 October 2021, for the prevention of COVID-19 infections. Even so, this critical and threatening situation of pandemic and due to various variants’ emergence, the pandemic control has become challenging; this calls for gigantic efforts to find new potent drug candidates and effective therapeutic approaches against the virulent respiratory disease of COVID-19. In the respiratory morbidities of COVID-19, the functionally crucial drug target for the antiviral treatment could be the main protease/3-chymotrypsin protease (Mpro/3CLpro) enzyme that is primarily involved in viral maturation and replication. In view of this, in the current study I have designed a library of small molecules against the main protease (Mpro) of coronavirus SARS-CoV-2 (2019-nCoV) by using multimodal generative neural-networks. The scaffold-based molecular docking of the series of compounds at the active site of the protein was performed; binding poses of the molecules were evaluated and protein-ligand interaction studies followed by the binding affinity calculations validated the findings. I have identified a number of small promising lead compounds that could serve as potential inhibitors of the main protease (Mpro) enzyme of coronavirus SARS-CoV-2 (2019-nCoV). This study would serve as a step forward in the development of effective antiviral therapeutic agents against the COVID-19.
Corrosion Inhibition, Adsorption and Thermodynamic Properties of Poly (Sodium 4-Styrenesulfonate) on Carbon Steel in Phosphoric Acid Medium
Authors:   Higher School of Applied Sciences, P.O. Box 165 RP, Tlemcen, 13000, Algeria, Attar Tarik , Benchadli Abbes ,   Laboratory of ToxicoMed, University of Abou Bekr Belkaïd, B.P.119, Tlemcen, 13000, Algeria, Boulanouar Messaoudi ,   Higher School of Applied Sciences, P.O. Box 165 RP, Tlemcen, 13000, Algeria, Choukchou-Braham Esma ,   Laboratory of ToxicoMed, University of Abou Bekr Belkaïd, B.P.119, Tlemcen, 13000, Algeria
Published: July 2022

The use of polymers as corrosion inhibitors has attracted much attention due to their low prices, inherent stability, availability and cost-effectiveness. The corrosion inhibiting effect of poly(sodium-4-styrenesulfonate) on carbon steel in phosphoric acid solution has been investigated using weight loss and scanning electron microscopy techniques (SEM) and theoretical calculations based on density functional theory (DFT). In the presence of 1.0×10-3 mol/L of inhibitor, a maximum inhibition effect of 98.06 % was observed. The influence of the concentration of the inhibitor, the temperature of the solution and the immersion time on the corrosion of carbon steel was investigated. Activation parameters such as activation energy (Eact), activation enthalpy (ΔHact), activation entropy (ΔSact), heat of adsorption (Qads) and adsorption free energy (ΔGads) were evaluated based on the effect of temperature on the corrosion and inhibition processes. It was found that the adsorption behaviour of poly(sodium-4-styrenesulfonate) (PSS) follows the Langmuir isotherm and the free energy change values indicate mixed chemical and physical adsorption on the carbon steel surface. The results obtained with the different methods agree well.
Features of Indicators of Blood General Clinical Analysis and the Summary Analysis of an Organism’s General Reactivity at Chronic Inflammatory Process
Authors:   Zaporizhzhya State Medical University and Khorticky National Academy, Sokolovskaya Irina
Published: July 2022

Inflammatory diseases cause health disorders which result in a reduction of the population. That is why this medical problem is considered to be a very important one. The human immune system is responsible for protecting the body from infections of various origins, while inducing chronic inflammation (characterized by a long, often invisible course) which can result in proneness to recurrence, complications and resistance to therapy. The authors of the article analyzed and proved that there are immune status shifts in patients with chronic nonspecific inflammatory processes depending on the pathogen, phase and level of damage.
Promoção da saúde de estudantes universitários: a influência das habilidades sociais
Authors: Jesus Maria Camila Azeredo de , Andrade Elisabete Agrela de
Published: August 2022

O presente estudo objetivou analisar a influência das Habilidades Sociais na qualidade de vida do estudante universitário (n = 923) de uma instituição de ensino superior na capital paulista. Como método, realizou-se um estudo exploratório, de caráter descritivo e natureza quantitativa. Para coleta de dados, foram aplicados questionário sociodemográfico, Inventário de Habilidades Sociais (IHS-Del-Prette) e WHOQOL-Bref. Foram realizadas análises estatísticas com GraphPadPrism. Os resultados mostraram que houve predomínio de jovens (80,04%), mulheres (63,2%); e foi encontrada correlação significante entre os escores de qualidade de vida e de habilidades sociais. Concluiu-se que, quanto maiores os índices de habilidades sociais, maior a qualidade de vida dos estudantes universitários. Isso remete ao potencial de construção de ambientes saudáveis que fomentem o desenvolvimento de habilidades sociais, geradoras de universidades promotoras de saúde.
Features of cognitive mental processes and neurodynamic properties of the central nervous system in firefighters depending on polymorphisms of the regulators’ genes of the brain monoamine system
Authors: Kriyt Vladimir E. , Sannikov Maksim V. , Gudkov Andrey B. , Sladkova Yuliya N. , Nikanov Aleksandr N. , Pyatibrat Alexander O.
Published: August 2022

BACKGROUND: Firefighters' performance of their occupational duties is associated with significant psycho-emotional stress, as well as the complex influence of harmful and dangerous factors that are a source of risk to their health and life. One of the most important modern tasks of vocational training of employees in the EMERCOM of Russia is the problem of assessing psychophysiological reserves. Currently, traditional methods of psychological and psychophysiological testing do not allow a full assessment of psychophysiological reserves because the degree of adaptation to extreme loads is determined by hereditary traits.
AIM: To study the features of cognitive mental processes and neurodynamic properties of the central nervous system in firefighters that depend on the polymorphisms of the regulators genes of the monoamine system of the brain.
MATERIAL AND METHODS: Methodologically, 453 people were examined, of which 234 were the main group (firefighters), and 219 were the control group. Assessment was conducted using the following methods: "Correction test with Landolt rings", "Mnsterberg test", "Schulte tables", "Reaction to a moving object", "Simple visual-motor reaction", and KR-3-85 test batteries. Genotyping was performed using five candidate genes of 5-HTTLPR or 5HTT, 5HT2A, COMT, DRD1, and DRD2/ANKK1.
RESULTS: The results of indicators of attention, neurodynamic properties of the central nervous system, and cognitive mental processes, depending on the nature of the occupational tasks performed and employment duration, indicates the strain of the functional systems of the body during long-term work (more than five years) in the main study group (firefighters). Firefighters carrying 5HTT L/L, 5HT2A C/C, COMT Val/Val, and DRD2/ANKK1 Glu/Glu genotypes have significantly higher rates than those of 5HTT S/S, 5HT2A Т/Т genotypes, COMT Met/Met, and DRD2/ANKK1 Lis/Lis, and at the same time lower indicators compared to individuals with similar genotypes from the control group.
CONCLUSION: The data obtained indicate the feasibility of practical application of studies of the 5HTT, 5HT2A, and DRD2/ANKK1 genes. Changes in the level of attention and neurodynamic properties of the central nervous system depending on the polymorphic variants of the DRD1 gene were not observed. The indicators of cognitive mental processes in the control and main groups differed depending on the polymorphic variants of the COMT gene.
Robot-assisted partial nephrectomy with calicolithotomy
Authors: Mosoyan Mkrtich S. , Shanava Gocha Sh. , Simonyan Arthur M. , Aysina Nadezhda A.
Published: July 2022

The combination of renal cell carcinoma and urolithiasis in the same kidney is rare. The management of patients who have two such diseases simultaneously is primarily determined by renal cell carcinoma as the dominant disease. To date, modern diagnostic and surgical technologies make it possible to perform partial nephrectomy with simultaneous removal of a calculus from the pelvicalyceal system using minimally invasive endovideosurgical methods.
This study aimed to demonstrate the possibility of performing robot-assisted nephrectomy with calicolithotomy in a patient with abnormalities of renal vessels.
This work presents a clinical case of a 36-year-old man hospitalized with a neoplasm of the right kidney measuring 38 35 35 mm, detected during multislice computed tomography. In the lower group of calices of the kidney, a 5 4 mm calculus with a density of 1200 HU was found. The presence of anomalies of the renal vessels served as the basis for a three-dimensional (3D) reconstruction of the right kidney using the 3D Slicer modeling program. The patient underwent a robot-assisted kidney resection with calicolithotomy on a da Vinci SI robot. Intraoperatively, an ultrasound examination of the kidney was performed using an intracavitary sensor BK Flex Focus 800.
The console operating time of the operating surgeon was 110 min. Blood loss was approximately 100 ml. The warm ischemia time was 20 min. The postoperative period proceeded without complications. At 3 weeks postoperatively, nephrogenic arterial hypertension disappeared. Laboratory studies conducted 3 months after surgery indicated an increase in the glomerular filtration rate compared with preoperative results.
3D reconstruction allows rational planning of the scope of surgical intervention during preoperative preparation. Kidney resection with calicolithotomy is optimally performed using the da Vinci robot, which allows complex surgical techniques to be performed using endovideosurgical methods.
Ungual Melanoma Disguised by Onychomycosis
Authors: Lee Jungsoo , Yun Jisang , Shin Kihyuk , Ko Hyunchang , Kim Byungsoo , Kim Moon-Bum , Kim Hoonsoo
Published: July 2022

Ungual melanoma is known to be frequently misdiagnosed, and the primary misdiagnosis of ungual melanoma
includes onychomycosis. We report a very rare case of onychomycosis concealing ungual melanoma in situ. A 52-
year-old male patient presented with a yellow to brown thickened left great toenail that had existed for 10 years. In
the front view, Hutchinson's sign which refers periungual extension of brown-black pigmentation from melanonychia
was also observed on his hyponychium. First, fungal infection of his toenail was confirmed with positive KOH
result. Next, a nail biopsy after nail avulsion was done to assess Breslow depth and to determine surgical margin.
And ungual melanoma was diagnosed with immunohistochemical stains. Non-amputative wide local excision with
5 mm surgical margin followed by skin grafting was done Unfortunately in three years ungual melanoma in situ
has recurred 2 times and then progressed to invasive malignant melanoma, so he was referred to the Department
of plastic surgery for further invasive surgical treatment and regularly monitored to check the recurrence. According
to a prior retrospective study, 52% of ungual melanomas were clinically misdiagnosed. Thus, proper diagnosis of
ungual melanoma is very important for the patients' better prognosis. It would be important for physicians to
examine the nail plate as well as the underneath structures for patients with nail disease including onychomycosis.
«L’enigma dell’esistenza dell’altro». Empatia e intersoggettività in Edith Stein
Authors: Di Chiro Antonio
Published: July 2022

In this paper we will try to reconstruct, starting from Husserl’s path, the genesis of Edith Stein’s philosophical itinerary and to show that, just in her detachment from Husserl’s orthodoxy, Stein will end up opening new paths to phenomenology and to reckon with questions left open by the father of phenomenology. Therefore, we will try to show that one of the most interesting aspects of the husserlian legacy revolves around the concepts of empathy and intersubjectivity developed in Edith Stein’s reflection. Moreover, we will try to refute Paul Ricoeur’s remark that speaks of an illusion arising from all attempts of phenomenology to account for the existence of the other and, in doing so, we will see that the solution proposed by Stein is not only not disappointing at all but contributes to open the way to a phenomenology of otherness that does not merely flatten and confine the other to one’s self.
Il complessivo ed ultimo pensiero di Edith Stein nell’orizzonte della Fenomenologia ultra-husserliana di Karl Jaspers
Authors: Nuzzo Vincenzo
Published: July 2022

In this article we wish to look into the nature of Edith Stein’s thought, in the light of a specific work by Karl Jaspers (Psychologie der Weltanschauung), especially in order to clarify the matter of its possible close dependence on Husserl’s Phenomenology during the mystical phase of her work. Especially, we theorize that the path followed by Stein has widened the field of Phenomenology to a much extensive horizon than that traced by Husserl. The reading of the work of Karl Jaspers had offered us various ideas on this context, especially for the following aspects: 1) the primacy of “observational psychology” over philosophy as the ultimate scenario for validating knowledge; 2) the achievement of a balanced position between idealism and realism; 3) a justification of metaphysics and mysticism that is independent of the rigorous philosophical rationalism still present in Husserl’s Phenomenology. The grounds of this thesis were obtained by analyzing the Jaspers’s texts and by comparing them with the Stein’s thought, and finally by focusing on the following themes: 1) type of phenomenology; 2) concept of formation; 2) realist ontology.
Edith Stein : une philosophie juive ? De quelques résonnances philosophiques avec Martin Buber et Franz Rosenzweig
Authors: Bouillot Bénédicte
Published: July 2022

What relationship does Edith Stein’s philosophy have with her Judaism? If her works offer little evidence to address the question directly, a comparison of her thought with that of Jewish authors of her generation can provide valuable insights into her links with the Jewish world. This study endeavors to show that Stein’s philosophy shares with those of Buber and Rosenzweig several characteristics which mark a real originality with regard to the dominant thought of their time, and which are explicitly linked, for the latter, to Jewish sources: the precedence given to otherness in the face of egological philosophies; a way of thinking about the universal which does not deny, but honors, the value of the singular; and a concern, finally, with showing the presence of God rather than demonstrating his existence. Thanks to these connections, Stein’s philosophy can be seen as implicitly marked by Judaism in many of its fundamental features. Even his conception of Christian philosophy, which is totally unprecedented, can be understood as inspired by a way peculiar to Jewish philosophers of honoring the requirement of universality of philosophical reason, while at the same time being nourished by a religious heritage.
A Ética do Limite em Eugenio Trías: a Inteligência Prática como Condição para o Alcance da Felicidade
Authors: Dimas Samuel
Published: July 2022

The philosophy of Eugenio Trías contains reflections on the practical usage of reason that seeks conciliation between the universality and unconditionality of the ethical imperative and the existential particularity of the free and responsible response to this transcendental proposal that is revealed through the voice of the conscience. Against the acritical and dogmatic positions of myth and of pure reason and against the cultural relativisms of historical reason, he proposes a symbolical rationality through the mediation between the physical reality and the metaphysical reality that establishes the terms of conciliation between heteronomy and moral autonomy. The desire for a good and happy life is satisfied not in the totalitarian utopias of liberal individualism and despotic collectivism or the illusory eschatologies of myth and superstition but rather in the just measuring of the limited condition of humans on the threshold between the natural world of appearance and the supernatural world of mystery.
Nietzsche e o radicalismo aristocrático: um comentário a partir de Georg Brandes
Authors: Feiler Adilson
Published: July 2022

Nietzsche’s thought is received in Scandinavia through the Danish historian Georg Brandes. The historian is attracted by the aristocratic aspect that emerges from Nietzsche’s reading of culture. Radicality, originality and psychological detail, which can be seen in the philosophical spirit of the German thinker, permeate Brandes’ reading of the author of Zarathustra. Nietzsche himself testifies to how much his name, thanks to Brandes, comes to be known in Denmark in several of his letters and other writings, even attesting to a correct understanding of his thinking. Our proposal is intended to ascertain the role that memory, in its aristocratic sense, has to contribute to Brandes’ Nietzschean reception. To what extent can mnemotechnics point the way to an aristocratic culture for Denmark of Brandes?
Diabetic Ketoacidosis and Acute Coronary Syndrome Due to Neck Abscess
Authors: Prabowo Nurhasan , Dewi Hana , Nugraha Adhizti , Ardyanto Tonang
Published: August 2022

Diabetic ketoacidosis (DKA) is a life-threatening consequence of diabetes mellitus. Infection is the most common cause of DKA. A 41-year-old man came to the hospital emergency department with shortness of breath the day before, nausea, vomiting, coughing, pain and swelling in the left neck. The patient has a history of uncontrolled diabetes. A physical examination revealed Kussmaul's breathing and a lump the size of a tennis ball on the left side of his neck. Laboratory findings are: leukocytosis, an increase in blood sugar of 512 mg/dL; blood gas analysis shows acidosis, ketone examination reveals ketonuria; Electrocardiography shows waves of ischemic heart disease, with elevated Hs Troponin. Fine needle examination of the lump shows a neck abscess. The patient was diagnosed with DKA in type 2 diabetes mellitus, with the acute coronary syndrome and neck abscess. Surgical debridement, antibiotics, acute coronary syndrome therapy, and DKA therapy are treatments. The patient responded well to treatment.
PCBs and Dioxins Either Cause or Make Worse Both Osteo and Rheumatoid Arthritis
Authors: Mohammad Azad , Carpenter David
Published: August 2022

Rheumatoid arthritis is an autoimmune disease, while osteoarthritis is presumed to be a disease due to wear and tear causing damage to joints. Some environmental exposures, such as smoking, air pollution and possibly persistent organic pollutants, are known to increase the risk of both. We have utilized the National Health and Nutrition Examination Survey (NHANES) data to determine associations between self-reported prevalence of any form of arthritis, rheumatoid and osteoarthritis and various polychlorinated biphenyl (PCB) congeners, several chlorinated pesticides and 2.3,7,8-tetrachloro-dibenzo-dioxin (TCDD). We find that there is a statistically significant association between serum PCB levels of more highly chlorinated PCB congeners and both types of arthritis. The associations are stronger with rheumatoid arthritis than with osteoarthritis, and stronger in women than in men.