bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovering the Great Royal Seal: New Reality of Vygotsky’s Legacy
Authors: Veresov N.N.
Published: July 2020

The paper explores contemporary state of arts in the perception of cultural-historical theory (CHT) by the international scholarly community. On one hand, we do have a great number of publications exploring and advancing Vygotsky’s legacy in many ways and directions. On the other hand, paradoxically, there is still no agreement about what CHT is as a theory, and what are its subject-matter, laws, principles and research method. The current state of arts could be expressed by the metaphorical words “Christianity without Christ”. The problem is that the existing exposition of CHT appeared over 30 years back, when only a limited number of Vygotsky’s original texts were available. But the new reality, with Vygotsky’s legacy connected by the publication of a significant number of his unknown previously writings and recent archival findings, allows us to improve the existing exposition of CHT. This article provides an example of how this new reality brings solutions to several problems, such as 1) the title of the theory; 2) its subject-matter and 3) the system of laws of psychological development. The last part of the paper indicates several problems and issues to resolve in discovering CHT as a wholistic theoretical system.
Mental Development in Early Childhood
Authors: Leontiev A.N.
Published: July 2020

This is the first English translation of the paper of the prominent Soviet scholar Alexey Nikolaevich Leontiev (1903—1979) published in 1948. The paper introduces the author’s ideas on mental and personality development in preschool children based on the research results of his close colleagues under his leadership during the 1930-s and 1940-s. It embraces the conditions and features of the development of the hierarchy of motives in preschoolers which underlies the emergence of volitional behaviour at this age. Evidence is provided for the role of the motivational structure in the volitional regulation of such cognitive processes as perception, memory and in the emergence of children’s control of their motor processes. It demonstrates that the motives of the child of the preschool age get subordinated when the child is engaged in the social interaction with the participation of an adult. In a brief preface to this publication, E.E. Sokolova highlights the context of the author’s work, the continuity of his ideas of the activity theory with Vygotsky’s approach, and emphasizes a nontrivial approach in Leontiev’s school to mental development as rooted in the total activity of the subject rather than in the brain processes
Efecto del cine en el significado cultural del concepto jubilación en un grupo de jubilados agremiados
Authors: Aguilera-Velasco Maria de los Angeles , Acosta-Fernandez Martín , Garcia-Franco Jose Hector
Published: July 2020

Objetivo: Analizar el efecto del ciclo de cine “Mirar y reflexionar la jubilación” en el significado cultural del concepto de jubilación en un grupo de jubilados agremiados.Métodos: Estudio cualitativo pre-experimental exploratorio, con diseño de intervención socioeducativa a través de cuatro fases: diagnóstico, planificación, implementación y evaluación, realizado en una casa de día para jubilados de Guadalajara, México, durante siete meses continuos en el 2018. Participaron trabajadores administrativos jubilados provenientes de una misma universidad pública. Los datos se recolectaron con la técnica de listados libres, antes y después del ciclo de cine. La intervención se integró con una conferencia sobre las etapas de la jubilación y la proyección de 25 películas sobre jubilación. Se llevó a cabo análisis de dominios culturales.Resultados: Antes de la intervención el significado cultural del concepto fue descanso. Después de la intervención, se definió a la jubilación como alegría.Conclusiones: El ciclo de cine modificó el significado cultural del concepto de jubilación en el grupo de participantes.
FIRST AND SECOND LAW EVALUATION OF COMBINED BRAYTON-ORGANIC RANKINE POWER CYCLE
Authors: KAŞKA Önder , BOR Onur , TOKGÖZ Nehir , AKSOY Muhammed
Published: July 2020

In the present work, we have conducted thermodynamic analysis of an organic Rankine cycle (ORC) using waste heat from intercooler and regenerator in Brayton cycle with intercooling, reheating, and regeneration (BCIRR). First of all, the first law analysis is used in this combined cycle. Several outputs are revealed in this study such as the cycle efficiencies in Brayton cycle which is dependent on turbine inlet temperature, intercooler pressure ratios, and pinch point temperature difference. For all cycles, produced net power is increased because of increasing turbine inlet temperature. Since heat input to the cycles takes place at high temperatures, the produced net power is increased because of increasing turbine inlet temperature for all cycles. The thermal efficiency of combined cycle is higher about 11.7% than thermal efficiency of Brayton cycle alone. Moreover, the net power produced by ORC has contributed nearly 28650 kW. The percentage losses of exergy for pump, turbine, condenser, preheater I, preheater II, and evaporator are 0.33%, 33%, 22%, 23%, 6%, and16% respectively. The differences of pinch point temperature on ORC net power and efficiencies of ORC are investigated. In addition, exergy efficiencies of components with respect to intercooling pressure ratio and evaporator effectiveness is presented. Exergy destructions are calculated for all the components in ORC.
MULTI OBJECTIVE OPTIMIZATION OF WASTE HEAT RECOVERY IN CEMENT INDUSTRY (A CASE STUDY)
Authors: SANİ Mostafa Mostafavi , NOORPOOR Alireza , MOTLAGH Majid Shafiepour
Published: July 2020

Cement plants have the potential points to waste heat recovery. The method studied in this paper is based on the use of air quenching chamber (AQC) and suspension preheater (SP) Boilers which are installed at the output of the clean cooler and preheating stage respectively in Cement Plant. Due to the low temperature of the existed gases, three different fluids, water, R123 and R245fa are used as the working fluids and are evaluated in a similar cycle in terms of energy, exergy and the optimum parameters selection based on genetic algorithm. The results of this study showed that fluid R123 with optimized parameters leads to a 4% increase the total exergy loss and also will increase the production power from 5 MW to 9 MW. That is while in the case of water production power is increased from 4.8 to 5 MW is optimal state. Also the Results showed that the cost of produced electricity and exergy efficiency are lower in the case of organic fluid application in comparison with water as working fluid.
PRIMEROS REGISTROS DE Oxyura jamaicensis andina EN ECUADOR
Authors: Arteaga-Chávez William Andrés
Published: July 2020

El Pato Rojizo Oxyura jamaicensis andina se distribuye en los Andes Centrales y el Altiplano Cundiboyacense, en Colombia. Representa un plumaje intermedio entre O. j. jamaicensis y O. j. ferruginea, con una marcada variación individual en el patrón de plumaje en toda su área de distribución, que ha derivado en que se cuestione su validez taxonómica. En esta nota informo sobre los primeros registros de O. j. andina en Ecuador, extendiendo su área de distribución en c. 250"’650 km hacia el sur, dentro del ámbito de distribución de O. j. ferruginea.
Psychiatric Implication of Eyelid Tattooing
Authors: Bidaki Reza , Dehghan Mohammad Javad , Negintaji Sina , Saghafi Fatemeh , Sahebnasagh Adeleh
Published: July 2020

A tattoo is a permanent design created by injecting exogenous pigments into the dermis. Eyelid is an exotic place for tattooing. We present a 34-year-old man with eyelid tattooing as disorganized behavior.
Interesting Imaging in a Patient With Lung Cancer Due to Asbestosis
Authors: Bolbol Haghighi Anahita , Karim Pour Reyhan Sahar
Published: July 2020

Introduction: Asbestosis is a subtype of pneumoconiosis caused by asbestos that can lead to fibrosis and scarring the lung tissues.
Case Report: Some of the asbestos-related diseases are calcifications, malignant mesothelioma, and pleural effusion.
Conclusion: Asbestosis can cause cancer several years after the initial exposure, but it can remain asymptomatic for a long time. Here we present image of a patient with asbestosis related carcinoma.
Phytobezoar Within Meckel’s Diverticulum Presenting With Partial Intestinal Obstruction
Authors: Mosaddegh Reza , Ghafouri Mohammad Hossein , Rezai Mahdi , Maghsoudi Mohammad Reza , Beigmohammadi Farzaneh
Published: July 2020

Introduction: Meckel’s Diverticulum (MD) affects approximately 2% of the population. Phytobezoar is defined as a vegetable and fiber-based ball in the gastrointestinal tract. We report a rare case of phytobezoar within MD presenting with partial intestinal obstruction.
Case Reports: We hereby present a 20-year-old man who referred to the Emergency Department of a hospital with a two-day history of nausea, vomiting, abdominal pain, and constipation. He underwent a midline laparotomy with surgical exploration, which revealed an MD 60 cm proximal to ileocecal valve containing phytobezoar. Histopathology reported the extracted specimen as an MD without ectopic tissue.
Conclusion: Meckel’s diverticulum can be affected by bezoars as well as other parts of the gastrointestinal tract. We recommend that phytobezoar within MD be considered among differential diagnosis of bowel obstruction.
Taurine Activates BMP-2/Wnt3a-Mediated Osteoblast Differentiation and Mineralization via Akt and MAPK Signaling
Authors: PARK Minsu , CHOI Hyeon Kyeong , AN Jeung Hee
Published: July 2020

Background: We aimed to elucidate the preventive effects of taurine against osteopenia in ovariectomized (OVX) rats and the mechanisms by which taurine regulates osteoblastogenesis in vitro and in vivo.
Methods: The effects of the taurine on human osteoblast MG-63 cell differentiation and osteoblastogenesis effect in OVX rat were examined Konkuk University in 2018 by evaluating osteoblast differentiation, and expression of osteoblast-specific factors by western blotting analysis.
Results: Taurine supplementation significantly improved alkaline phosphatase (ALP) activity and mineralization in a concentration-dependent manner. Further, taurine induced the expression of osteogenic growth factors such as bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (RUNX2), small mothers against decapentaplegic 1/5/8 (SMAD1/5/8), wingless-type MMTV integration site family member 3A (Wnt3a), and collagen type 1 (COL-1) via mitogen-activated protein kinase (MAPK) and serine/threonine protein kinase (Akt). Moreover, the RUNX2 activity of the taurine-treated group was enhanced by proteinprotein interactions such as Wnt3a-induced p-AKT/RUNX2 and BMP-mediated SMADs/MAPK/RUNX2 interactions.
Conclusion: Our in vitro and in vivo results suggested that taurine can be considered as a potential therapeutic candidate agent for preventing bone loss in postmenopausal osteoporosis.
Two Rare Variants of Down Syndrome: Down-Turner Syndrome and Down Syndrome with Translocation (13;14): A Case Report
Authors: GUMUS Evren
Published: July 2020

In the present paper, we report two rare cases of Down syndrome (DS); mosaic Down-Turner syndrome and DS with rob (13;14). Patient 1 karyotype is mos 45,X[41] / 47, XX,+21[59] and patient 2 karyotype is 46, XY, rob (13;14)(q10;q10),+21. With these two unusual cases, we aimed to look at the most common numerical and structural chromosome anomalies from a different window and evaluate the phenotypic effect in the presence of different chromosomal anomalies. Our main goal is to evaluate the phenotypic characteristics of these two rare variants in the light of literature.
Comparison of Clinical Effectiveness for Lumbar Pain Reduction between Exercise Programs on Flat Surface and Proprioceptive Equipment
Authors: BAEK Woo Yeul , KIM Sang Soo , JU Sung Bum
Published: July 2020

The article's abstract is no available.
The Effectiveness of Positive Parenting Program (Triple-P) on General Health of Mothers of Pre-School Children with Intellectual Disability
Authors: ASHOR Mohammad , JALIL-ABKENAR Seyyedeh Somayyeh
Published: July 2020

The article's abstract is no available.
Antibiotic Treatment of Anaerobic Infections: Uncharted Land in Iran
Authors: MEMAR Mohammad Yousef , YEKANI Mina , AGHAZADEH Mohammad , BANNAZADEH BAGHI Hossein
Published: July 2020

The article's abstract is no available.
Applying the Distributed Lag Non-Linear Model (DLNM) in Epidemiology: Temperature and Mortality in Mashhad
Authors: ENTEZARI Alireza , MAYVANEH Fatemeh
Published: July 2020

The article's abstract is no available.
Cardiovascular Complications of Chronic Opium Consumption: A Narrative Review Article
Authors: ZIAEE Mojtaba , HAJIZADEH Reza , KHORRAMI Arash , SEPEHRVAND Nariman , MOMTAZ Saeideh , GHAFFARI Samad
Published: July 2020

Opiates are the second most prevalent abused illicit substance after cannabis in the world. The latest United Nations Office on Drugs and Crime (UNODC) report estimated 30% increment in opium cultivation worldwide. High prevalence of opium consumption in eastern countries may be due to the high availability and traditional misconceptions. Opium consumption has been linked to hypertension, diabetes mellitus, dyslipidemia, and coronary artery diseases (CAD). In this review, we will review the association between opium use, cardiovascular diseases, and clinical outcomes. The present evidence suggests that chronic opiate consumption may increase the risk of cardiovascular diseases and related mortality.
Identification of Nonylphenol and Glucolipid MetabolismRelated Proteins in the Serum of Type 2 Diabetes Patients
Authors: YA Luo , JIE Yu , PAN Wang , CHANGWEI Yang , JIE Xu
Published: July 2020

Background: To identify serum nonylphenol (NP) and glucolipid metabolism-related proteins in Type 2 diabetes (T2D) patients.
Methods: We performed a hospital-based, case-control study in patients admitted to the Department of Endocrinology, Hospital of Zunyi Medical University, Zunyi City, China from Mar to Nov of 2014. The study included 112 T2D cases diagnosed in accordance with the 2013 WHO Expert Committee Diabetes Diagnosing Criteria, and 125 healthy individuals with normal fasting blood glucose (FBG) when receiving physical examination in the same period in the Municipal Physical Examination Center. Blood samples from subjects in the 2 groups underwent detection of biochemical indices, including FBG, blood fat, and NP. Glucolipid metabolism-related proteins, including estrogen receptor (ER), sterol regulatory element-binding protein-1c (SREBP-1c), wingless-type MMTV integration site family member 5a (Wnt5a), and peroxisome proliferatoractivated receptor-γ (PPAR-γ). These indices were compared between the 2 groups to analyze the correlation between serum NP levels and glucolipid metabolic proteins.
Results: The subjects in the diabetes group had higher triglycerides (TG), total cholesterol (TC), NP, ER, SREBP-1c, Wnt5a, FBG, and TG levels than the healthy group, but lower levels of low-density lipoprotein cholesterol (LDL-C) and PPAR-γ than the healthy group. No significant differences in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were found between the two groups. The serum NP levels were shown to be positively correlated with SREBP-1c but negatively correlated with PPAR-γ.
Conclusion: The serum NP levels of T2D patients is higher than the levels in healthy controls, and its levels correlate with SREBP-1c and PPAR-γ levels.
Super Infection of Cutaneous Leishmaniasis Caused by Leishmania major and L. tropica to Crithidia fasciculata in Shiraz, Iran
Authors: MIRZAPOUR Aliyar , BADIRZADEH Alireza , ASHRAFMANSOURI Marzieh , BEHNIAFAR Hamed , NOROUZI Maryam , AZIZI Hakim , BEHRAVAN Mahmoodreza , SEYYED TABAEI Seyyed Javad
Published: July 2020

Background: The aims of the current study were to determined present status of CL in Shiraz City, identify the causative species of Leishmania and conduct phylogenetic evaluations in detected parasites.
Methods: This study was conducted on 70 individuals with suspected CL that referred to the major health centers of Shiraz (Valfajr), Fars province, Iran, from Sep 2016 to Jul 2017. DNA was extracted from cultured Leishmania promastigotes and PCR-RFLP were performed using ITS1-rDNA gene.
Results: Overall, 39 male (55.70%) and 31 (44.30%) female were found to be positive microscopically. All of direct examined positive samples were confirmed to be positive for Leishmania spp. DNA. Based upon the PCRRFLP patterns and phylogenetic analysis, 46 (65.72%), 17 (24.28%) and 7 (10%) isolates were clearly identified as L. major, L. tropica and C. fasciculata, respectively.
Conclusion: The dominat detected species in Shiraz City was L. major and L. tropica, respectively. CL has high prevalence in Shiraz City; therefore, more studies on leishmaniasis in the natural vectors and also reservoirs infection in this region is exceedingly recommended. Skin leisons due to C. fasciculata, was described for the first time in Iran (Shiraz City).
Self-Medication in Mexican Pediatric Patients
Authors: ORTIZ Mario. I. , MARTÍNEZ JIMÉNEZ Beatriz , RAMÍREZHERNÁNDEZ Ricardo , CASTELÁN-CAMPOS María de Los Ángeles , CARIÑOCORTÉS Raquel , PONCE-MONTER Héctor A.
Published: July 2020

The article's abstract is no available.
The Advantages of Waist to Height Ratio over the Commonly Used Anthropometric Measurements in Preadolescents and Adolescents: A Case Study from Montenegro
Authors: MILASINOVIC Rajko , CVOROVIC Aleksandar , KUKIC Filip
Published: July 2020

The article's abstract is no available.
Violence against Primary Health Care Workers in Serbia and Measures for Ensuring Safe Work Environment
Authors: TERZIC-SUPIC Zorica J. , FISEKOVIC-KREMIC Marina B. , TODOROVIC Jovana , SANTRIC-MILICEVIC Milena M. , NESIC Dejan M. , TRAJKOVIC Goran Z.
Published: July 2020

The article's abstract is no available.
Magnesium Sulfate Combined with Nifedipine Is Effective in Pregnancy-Induced Hypertension and Reduces Levels of Serum β2- Microglobulin and Retinol Binding Protein 4
Authors: SONG Jie , LAN Ruihong , GONG Humin , ZHENG Linmei , YANG Yang , YI Dahua , HU Enze
Published: July 2020

The article's abstract is no available.
Forecast of the Future Trend of Accidents in an Electricity Distribution Company of Iran: A Time Series Analysis
Authors: KHAMMAR Alireza , HOSSEINIGHOSHEH Seyednouredin , ABDOLSHAHI Anna , HOSSEINI AHAGH Mirmohammad , POURSADEQIYAN Mohsen
Published: July 2020

The article's abstract is no available.
The Effects of Probiotic/Synbiotic on Serum Level of Zonulin as a Biomarker of Intestinal Permeability: A Systematic Review and Meta-Analysis
Authors: RAMEZANI AHMADI Amirhossein , SADEGHIAN Mehdi , ALIPOUR Meysam , AHMADI TAHERI Samira , RAHMANI Sepideh , ABBASNEZHAD Amir
Published: July 2020

Background: This systematic review and meta-analysis was conducted to obtain a conclusive result on the influence of probiotics/synbiotic on serum levels of zonulin. Data related to serum levels of zonulin were extracted to determine the effects of probiotic/synbiotic on intestinal permeability.
Methods: The literature search was conducted across the Cochrane Central Register of Controlled Trials, PubMed, Scopus and ISI Web of Science, Search up to Nov 2018. Clinical trials evaluating the effect of probiotic/synbiotic on serum zonulin levels of all human subjects were included.
Results: Nine studies (including 496 intervention and 443 control subjects) met the inclusion criteria for the meta-analysis. According to the meta-analysis, probiotic/synbiotic has a significant effect on serum zonulin reduction (WMD=-10.55 [95% CI: -17.76, -3.34]; P=0.004). However, the high level of heterogeneity was observed among the studies (I2=97.8, P<0.001). The subgroup analysis suggested study quality, blinding, study duration, Participants age, subject's health status and supplement type as sources of heterogeneity.
Conclusion: Probiotic/synbiotic have favorable effects on serum levels of zonulin as a measure of intestinal permeability. However, the results should be interpreted with caution due to the high heterogeneity and further evidence is required before definitive recommendations can be made.
Omitting ALND Is Not Safe for a Cohort of Early-Stage Breast Cancer Patients with 1-2 SLNs Macro-Metastases and BreastConserving Therapy: A Single-Center Retrospective Study
Authors: WANG Xiangyu , GAO Yinqi , YANG Xue , KONG Xiangyi , WANG Zixing , FANG Yi , WANG Jing
Published: July 2020

Background: Omitting axillary lymph node dissection (ALND) is recommended for early-stage breast cancer patients with 1-2 sentinel lymph nodes (SLNs) macro-metastases and breast-conserving therapy. However, it is not safe for part of patients, so it is significant to find risk factors and develop a predictive model of non-SLNs metastases in breast cancer patients with 1-2 SLNs macro-metastases and breast-conserving therapy.
Methods: This retrospective study enrolled 228 breast cancer patients with 1-2 SLNs macro-metastases who underwent ALND and breast-conserving surgery between Jan 2012 and Dec 2017 at Cancer Hospital Chinese Academy of Medical Sciences. Chi-square test and backward stepwise binary logistic regression were used to find factors that influenced non-SLN metastases, then a predictive model was formulated and obtained its area under the curve.
Results: Tumor pathologic invasion size, number of positive SLNs and ALN status on imaging was associated with non-SLNs metastases. The predictive model was also formulated based on these three factors to assess and the area under the curve of model was 0.708.
Conclusion: We developed a predictive model to assess the high-risk cohort of patients of non-SLNs metastases which can be an auxiliary tool for doctors.
Health Literacy of Rural Population of Kazakhstan
Authors: SHAYAKHMETOV Syrym S. , TOGUZBAYEVA Karlygash K. , ISMAILOVA Aigul A. , TABIBI Ramin , DERBISHALIEVA Zhypar K. , DZHUSUPOV Kenesh O.
Published: July 2020

Background: To date, there is no data available of health literacy of the population in Kazakhstan. This study was aimed to assess the health literacy of the rural population for the development of the targeted health education programs.
Methods: The adapted HLS-EU-Q47 survey was carried out among 1650 respondents aged 18-76 from rural settlements in Almaty region of Kazakhstan in 2013. The health literacy competences to assess, understand, appraise and apply health information on healthcare, disease prevention and health promotion were measured. The associations between the health literacy competencies and demographic and socio-economic characteristics were shown through a multiple linear regression analysis.
Results: The overall health literacy rate of the rural population of Almaty region was problematic and inadequate. With regards to their age, sex, social and economic characteristics, the health literacy competencies differ according to health literacy domain. Respondents with low education level or perceived social status had respectively low health literacy scores, especially in appraising and applying information of disease prevention.
Conclusion: Low educated people and with lower income have lower health literacy in comparison to respondents with higher education level and higher income. Respondents with higher health literacy have higher rate of self-assessed health.
Association between Serum Calcium and First Incident Acute Myocardial Infarction: A Cross-Sectional Study
Authors: ZHANG Chi , CAO Bangming , HUANG Xingmei , GU Jian , XIA Ming , YANG Xiangjun , LI Hongxia
Published: July 2020

Background: The role of serum calcium in coronary artery disease (CAD) patients with or without first incident acute myocardial infarction has not been studied previously. This study aimed to assess the relationship between serum calcium and first incident acute myocardial infarction.
Methods: This cross-sectional study was conducted from Jan 2014 to Dec 2016. All the participants were from our database, described in detail elsewhere including 1609 cases and 3252 controls. Multiple logistic regression was carried out to explore the effect of serum calcium on first incident acute myocardial infarction. Interaction between serum calcium and risk factors were evaluated.
Results: Patients with first incident acute myocardial infarction have significantly lower serum calcium concentrations than those without acute myocardial infarction (2.18 (0.21) vs 2.24 (0.19) mmol/L, P<0.0001). After adjusting for sex and age, logistic regression showed that serum calcium was significantly associated with first incident acute myocardial infarction (odds ratio (OR): 1.50, 95% confidence interval (CI): 1.41-1.60). Further adjusted for potential confounders, serum calcium was associated with first incident acute myocardial infarction (OR: 1.32, 95% CI: 1.22-1.42). Moreover, the association still existed when patients were divided into subgroups according to gender and age. A significant interaction was found between serum calcium and diabetes mellitus (DM), lipoprotein (a) (Lp (a)), and serum albumin.
Conclusion: Serum calcium was associated with first incident acute myocardial infarction among CAD patients in both sexes and in age categories. This study provides further evidence showing the value of serum calcium levels in clinical practice.
The Relationship between Risk Levels of Breast Cancer and Use of Early Diagnosis and Screening Services in Healthcare Workers in Turkey
Authors: ACIKGOZ Ayla , YORUK Selda , TURKMEN Hulya , ERGOR Gul
Published: July 2020

Background: This study aimed to determine the factors affecting early diagnosis and screening behaviors of healthcare workers concerning breast cancer and the breast cancer risk levels using the risk identification model and to evaluate the relationship between breast cancer risk levels and early diagnosis and screening behaviors.
Methods: Overall, 466 healthcare workers from Balikesir Province, Turkey participated in this cross-sectional study. Data were collected thanks to a questionnaire prepared by the researchers. Cuzick-Tyrer model was utilized to determine breast cancer risk levels.
Results: 78.1% of the healthcare workers regularly perform breast self-examination (BSE), 11.6% had clinical breast examination (CBE), 7.7% had breast ultrasound scan and 4.5% had mammography. BSE behavior increased, as education level got higher. Mammography screening behavior increased in those aged 40 yr and older and those with breast or ovarian cancer history in their family. There was not any relationship between breast cancer risk levels and early diagnosis and screening behaviors.
Conclusion: Early diagnosis and screening behaviors of healthcare workers were low concerning breast cancer. Age, education level and family history are the most prominent factors affecting early diagnosis and screening behaviors of healthcare workers. Informing healthcare workers on breast cancer risk factors and screening can make positive contributions to them and the public through them.
Effect of miR‑215 on the Expression of Tumor Suppressor Gene Rb1 in Retinoblastoma Cell Lines
Authors: SHAO Liqin , SHENG Zhangxing , ZHU Yuefeng , LI Jianchao , MENG Rufa
Published: July 2020

Background: Effect of miR-215 on the expression of tumor suppressor gene retinoblastoma (Rb)1 in Rb cell lines was investigated.
Methods: A total of 128 patients were selected. The expression of miR‑215 in cancer and adjacent healthy tissues of the 128 patients was detected by reverse transcription-quantitative PCR (RT-qPCR). HXO‑Rb44 and Y79 cell lines were transfected with miR‑215 analogs or miR‑215 inhibitors, and the expression of Rb1 protein in the cell lines was detected by western blotting.
Results: The expression of miR-215 in the adjacent healthy tissues of patients was significantly lower than that in cancer tissues (P<0.001). The expression of miR-215 in Y79 and HXO-Rb44 cells was significantly higher than that in APRE-19 cells (P<0.001). The expression of miR-215 in HXO-Rb44 cells was significantly higher than that in Y79 cells (P<0.001). The expression of miR-215 was statistically different from the degree of differentiation and nerve infiltration (P<0.05). The expression of Rb1 in cancer tissues was significantly lower than that in adjacent tissues (P<0.001), the expression of APRE-19 was significantly higher than that in Y79 and HXO-Rb44 cells (P<0.001), and the expression of Rb1 in HXO-Rb44 cells was significantly higher than that in Y79 cells (P<0.05). There was a negative correlation between miR-215 and Rb1 in the tissues of patients, and Rb1 expression decreased with the increase of miR-215 (r=-0.576, P<0.001).
Conclusion: miR‑215 is highly expressed in Rb cell lines, and is related to the clinicopathological features of this disease.
Cancer Risk Assessment for Workers Exposed to Pollution Source, a Petrochemical Company, Iran
Authors: HARATI Bahram , SHAHTAHERI Seyed Jamaleddin , YOUSEFI Hossein Ali , HARATI Ali , ASKARI Ali , ABDOLMOHAMADI Nabi
Published: July 2020

Background: Air pollution have led to severe problem of adverse health effect in the world. This study aimed to conduct the health risk assessment, cancer risk analysis, and non-cancer risk for exposure to volatile organic compounds (VOCs) and hydrogen sulfide (H2S) in petrochemical industry.
Methods: In this cross-sectional research, 123 samples were collected in the ambient air in Iran during winter 2016. For sampling and analysis of VOCs and H2S, 3 methods (numbers 1500, 1501, and 6013) presented by the National Institute of Occupational Safety and Health (NIOSH) were used. For determination of risk assessment of chemical pollutants, semi-quantitative method presented by the Occupational Safety and Health Division, Singapore was used. Finally, for calculation of cancer risk analysis, Chronic Daily Intake (CDI) and calculation of non-cancer risk, Exposure Concentration (EC) were used.
Results: Average concentration of benzene (2.12±0.95) in breathing zone of workers were higher than the Threshold Limit Values-Time Weighted Average (TLV-TWA) (P<0.05). Among chemical substance, benzene had very high rank of risk in petrochemical industry. Rank of risk for H2S, toluene, and xylene present in the breathing zone of workers was low. The mean cancer risk for workers exposed to benzene was estimated 8.78×10-3, in other words, 8.7 cancer per 1000 i.e. higher than the acceptable standard of 10-6 . In our study, non-cancer risk for BTX was higher than the acceptable standard of 1.
Conclusion: In particular, overall cancer and toxic risk can be associated with long term exposure to benzene.
How Often Do the Iranian Medical Journal Editors-in-Chief Publish in Their Own Journals?
Authors: REAEE-ZAVAREH Mohammad Saeid , KARIMI-SARI Hamidreza
Published: July 2020

There is no abstract available.
Stress-Coping Strategies and Factors Related Distress among Japanese Physicians
Authors: OTSUKA Yuichiro , KANEITA Yoshitaka , ITANI Osamu , NAKAGOME Sachi , JIKE Maki , OHIDA Takashi
Published: July 2020

There is no abstract availble.
A New Application of Louvain Algorithm for Identifying Disease Fields Using Big Data Techniques
Authors: Shirazi Saeed , Baziyad Hamed , Ahmadi Naser , Albadvi Amir
Published: July 2020

Background and aim: Recently, the use of data science techniques in healthcare has been increased remarkably. Community detection as one the important methods of data science is utilized in the health domain.
Methods: This paper detects disease areas based on combination of big data and graph mining methods on drug prescriptions. At first, network of prescription is designed, and Louvain algorithm is applied for community detection of 50000 Iranian prescriptions in 2014 gathered from the Iranian Health Insurance Organization. We use modularity metric for validation of the results and the experts’ opinion as the external validation of communities.
Results: The outputs are consist of six communities. These communities are labeled based on experts’ opinion that present the disease fields.
Conclusion: The Louvain algorithm has the ability to detect the major communities of the prescription database with an acceptable accuracy. We have proven that these communities present the disease fields.
Evaluation of the Relationship Between Depression, Anxiety, and Stress with Hypertension: Results of a Health Study in Yazd, Iran
Authors: Khajeh Mohammad , Mirzaei Masoud , Nadjarzadeh Azadeh
Published: July 2020

Background and Aim: Over the past few decades, different epidemiological studies have been conducted on the relationship between mental disorders and hypertension. However, conflicting results have been reported. This research aimed to evaluate the relationship between symptoms of depression, anxiety and stress with hypertension in a large population.
Materials and Methods: This cross-sectional analytic study was conducted using the results of in Yazd Health Study, Iran (N=9340). In addition, DASS-21 questionnaire was asked from the participants to assess depression, anxiety, and stress. Moreover, logistic regression was used to evaluate the relationship between symptoms of depression, anxiety and stress with hypertension.
Results: A negative association was observed between systolic and diastolic blood pressure and symptoms of depression, anxiety, and stress, which were independent from other variables. Regarding systolic blood pressure, a significant and reverse relationship was found in individuals with moderate stress (OR: 0.81, 95% CI: 0.69-0.95) and mild depression (OR: 0.82, 95% CI: 0.68-0.99). In terms of diastolic blood pressure, subjects with moderate stress had a lower blood pressure, compared to healthy individuals (OR: 0.86, 95% CI: 0.75- 0.99). Furthermore, participants with depression had a lower chance of being diagnosed with hypertension, compared to healthy individuals.
Conclusion: The present research did not confirm the previous assumptions about the relationship between depression, anxiety and stress with hypertension. Our findings showed that symptoms of depression, anxiety, and stress are correlated with a low blood pressure.
Designing a Quality Management Model for Health Services in Iran
Authors: Zarei Vajiheh , Tabibi Seyyed Jamaleddin , Mahmoodi Mahmood , Riahi Leila
Published: July 2020

Introduction: Nowadays, the quality of services, especially in high volume clients, such as financial and care services, has become increasingly important. Therefore, quality of service in accordance with professional standards and customer expectations is important and a first step for it is a quality improvement.
Objective: The purpose of this study was to design a quality management model for providing health care in Iran.
Method: In this study, the comparative method was used to evaluate the health care quality indicators in selected countries (America-England-Japan-Malaysia-Egypt) and to compare their health care strategies. Hospital managers and people responsible for improving hospital quality in Iran have been involved in this research (377 questionnaire were analyzed). The study lasted from September 2018 to September 2019. Maxqda software was used to classify the adaptive variables. Maxqda software was used to classify the adaptive variables. LISREL software were used- Exploratory and confirmatory factor analysis- to identify the dimensions and validation of the mode .
Results: Twenty-four types of health care variables were identified from 6 countries. Exploratory factor analysis and questionnaire resulted in four general criteri: Quality Assurance, Quality Planning, Quality Control and Quality Improvement. Confirmatory factor analysis also showed that the identified dimensions are valid .
Conclusion: Considering that guarantee,control, planning and quality improvement have the highest impact respectively, continuous planning at the level of hospitals can lead to a significant increase in the quality of health care delivery.
How Can Persian Medicine (Traditional Iranian Medicine) Be Effective to Control COVID-19?
Authors: Beygom Siahpoosh Marzieh
Published: July 2020

There is no abstract availble.
Evaluation of Invertase Inhibition Activity and Cytotoxicity of Ethanol and Acetone Extracts of Swietenia macrophyllia Leaves, Syzygium cumini and Trigonella foenum-graecum Seeds
Authors: Debnath Asim , Salim Mohammad , Miah Md Faruque , Karim Rezaul , Alam Md Jahangir
Published: July 2020

Invertase, the key enzyme responsible for sucrose hydrolysis. Inhibition of invertase can decrease the postprandial blood sugar level in diabetic patients and keep the blood glucose level normal where cytotoxicity to fast-growing cells like those of brine shrimp (Artemia salina) nauplii is a great measurement for further important drug development. This study was aimed to investigate potential anti-diabetic and cytotoxic activities of the ethanol and acetone extracts of Swietenia macrophylla leaves, Syzygium cumini and Trigonella foenum-graecum seeds. Invertase inhibition activities of S. macrophylla leaves, S. cumini, and T. foenum-graecum seeds were measured by spectrophotometrically using standard protocols and cytotoxicity were measured by brine shrimp lethality bioassay. Among the plant extracts, all ethanol extracts showed higher invertase inhibition activities than all acetone extracts. S. cumini seed ethanol extract showed the highest invertase inhibition activity whereas S. macrophylla leaves acetone extract showed the lowest invertase inhibition activity. The maximum toxicity was observed in ethanol extract of T. foenum-graecum seed whereas the lowest toxicity was observed in acetone extract of S. macrophylla leaves. Both ethanol and acetone extract of T. foenum-graecumseeds showed significant cytotoxic activities. This investigation suggested that S. cumini and T. foenum-graecum seeds possess potential antidiabetic activities and T. foenum-graecum seeds have potential cytotoxicity.
A Retrospective Cohort Study of Herbal Medicines Use during Pregnancy: Prevalence, Adverse Reactions, and Newborn Outcomes
Authors: Raoufinejad Kosar , Gholami Kheirollah , Javadi Mohammadreza , Rajabi Mehdi , Torkamandi Hassan , Moeini Ashraf , Mohebbi Niayesh
Published: July 2020

This study aimed to investigate the herbal medicines use prevalence and adverse drug reactions (ADRs) during pregnancy as well as the probable effects on newborn outcomes. Postpartum women with a live singleton infant were eligible if declared consent before discharge. Data was collected retrospectively by face-to-face interviews. Generally, 400 pairs of mother/infant were recruited. At least one herbal medicine was used by 325/400 (81.3%) women. Peppermint, frankincense, flixweed, olive oil, and cinnamon were the most common herbs. Overall, 26 ADRs were reported by 19/325 (5.8%) women. Gastrointestinal complaints were the most frequent herbal ADRs (18/26, 69.2%). Gestational age, Apgar scores, birthweight, complications, and malformations of newborns were similar between groups. In conclusion, herbal medicines were highly used by pregnant women, while they did not affect newborn outcomes either positively or adversely. Despite low frequency rate of herbal ADRs during pregnancy, their safety, efficacy, interactions, and potential risks need further studies.
Wet Cupping and Phlebotomy in Management of Oligo/Amenorrhea: View of Persian Medicine
Authors: Meyari Azam , Ramezani Tehrani Fahimeh , Tansaz Mojgan , Mokaberinejad Roshanak , Biglarkhani Mahdi
Published: July 2020

Oligo/amenorrhea is one of the most common women’s complaints. The most frequent pathologic causes of this condition is polycystic ovaries that leads to unovulatory cycles. Because of insufficiency of treatment in conventional medicine, we studied view point of Persian Medicine. We searched main Persian Medicine references to collect important information about wet-cupping and phlebotomy in treatment of oligo/amenorrhea especially in patients with Polycystic Ovarian Syndrome. For gathering evidence that establish this idea, we searched main English and Persian language databases for studies about effectiveness of wet-cupping and phlebotomy on menstruation. Excretion blood from lower extremities especially saphenous vein phlebotomy and calves wet-cupping while massive blood excreting is recommended by Persian physicians in Ehtebas-e-tams (oligo/amenorrhea). From the 106 citations identified from electronic searches, at beginning, 3 ones meet our study objectives. These articles showed that wet-cupping effect on menstruation in women with PCOS and fertilization. Although any study didn’t find about effectiveness of phlebotomy on menstruation or fertilization, but majority studies show effect of phlebotomy or blood donation on decrease of insulin resistance. More research about treating this condition needed to confirm the affectiveness of phlebotomy or wet-cupping in treatment of oligo/amenorrhea.
Numerical Simulation of the HIFiRE-1 Ground Test
Authors: Silvestrov P.V. , Surzhikov S.T.
Published: July 2020

The paper considers the problem of simulating the HIFiRE-1 ground test numerically. The aircraft geometry is represented by either a pointed or a blunted cone combined with a flared cylinder. Our digital simulation investigated the aerodynamics of two aircraft configurations: one featuring a pointed nose, another featuring a blunted nose with a radius of 2.5 mm. We used the UST3D software developed in the Ishlinsky Institute for Problems in Mechanics RAS, to perform our aerodynamic calculations. The software is specifically designed for numerical simulations of aerodynamics and thermodynamics in high-velocity aircraft. It implements a model of viscous compressible thermally conductive gas described by a non-steady-state spatial system of Navier --- Stokes equations solved over unstructured three-dimensional tetrahedral meshes. We compared the numerical simulation results in the form of pressure distribution in the tail segment of the aircraft to the empirical data obtained via ground tests in a wind tunnel. We analysed result convergence as a function of the mesh density used. We used methods of computational aerodynamics to investigate the turbulent flow field over the computation region from the leading shock wave to the far wake for various Mach numbers and attack angles
Implementing Production of Seasonal Demand Goods at Industrial Enterprises
Authors: Aleksandrov An.A.
Published: July 2020

The paper states an industrial engineering problem concerning industrial enterprises manufacturing goods for seasonal industries and activities. We developed a method for selecting optimum enterprise production capacity and forming a production plan that allows for meeting seasonal increases in demand, simultaneously ensuring rational utilisation of human resources, manufacturing equipment and storage facilities. The basis of the method is seeking the production volume function by minimising total expenditures for storage and manufacturing of goods, provided the seasonal demand is fully met over the whole period. We present a numerical implementation algorithm for our method and a calculation example. The main stages of the algorithm are as follows: setting the demand function; computing the core production capacity as dictated by steady equipment utilisation; varying the production plan until the minimum total expenditure condition is met. We ran a series of simulations that allowed us to establish the function describing the optimum production capacity as a fraction of the core capacity for various ratios of manufacturing expenditures to storage expenditures, and as a function of the overpayment rate for additional capacities
Effect of Autoclave Processing Parameters used to Form Hybrid SIAL Parts on the Structure and Properties of Al-Li Alloy 1441 Sheets
Authors: Serebrennikova N.Yu. , Konovalov A.N. , Sudarchikova M.A. , Karpukhin S.D. , Kolmakov A.G.
Published: July 2020

The paper considers the main stages of developing hybrid composite materials similar to GLARE, such as SIAL, on the basis of alloy 1441 sheets. The technology of manufacturing aviation products via auto-clave forming of such materials includes additional episodes of heating the thermally processed alloy 1441 sheets that form part of the hybrid material structure. Studying the microstructure of the Al-Li alloy sheets, the number of emergent phases and their mechanical properties shows that there is no considerable variation to be found in the properties of the SIAL hybrid composite material as a result of the alteration taking place

The work is performed as part of actualising a comprehensive field of research 6.2 "Laminate fracture-resistant, high-strength metal-polymer materials" ("Strategic areas of developing materials and material processing technology for the period up to 2030")
Peak Load Balancing for Engineering Vehicles
Authors: Popov I.P.
Published: July 2020

The paper considers the possibility of equipping engineering vehicles with inertial capacitance energy storage units, which should allow the power plant loads to be evened out, in turn leading to reducing the output power, mass and dimensions of the plant. In a range of engineering vehicles, such as excavators, bulldozers, diesel shunter locomotives and so on, loads are of a substantially irregular character. Peak loads are what determines the output power of power plants. It is evident that the power plant is not fully loaded most of the time. We propose a technological solution for balancing peak loads in engineering vehicles. Since operation modes of engineering vehicles change relatively frequently, it is efficient and advisable to equip them with energy storage units. The storage unit will not only level the power plant load, but also allow the energy to be recuperated during deceleration, which should improve the energy efficiency of the machine. We present the theoretical background required to develop an inertial capacitance energy storage unit, which is implemented as a direct current machine featuring a super flywheel. Employing flywheels in engineering vehicles is feasible due to their total mass requirements being flexible. Another advantage of certain engineering vehicles is their electro-mechanical transmission, the presence of which should minimise the development effort concerning the inertial capacitance energy storage unit discussed in the paper engineering vehicle, energy storage unit, super flywheel, power plant, energy efficiency
Hybrid Fusion-Fission System with Neutron Source Based on Deuterium Plasma
Authors: Chirkov A.Yu.
Published: July 2020

Development of hybrid fusion-fission systems appears today as a promising area in practical use of thermonuclear fusion energy. Thermonuclear plasma in such systems is the source of fast neutrons with the power gain factor Q < 1 power amplification factor in plasma. Hybrid system high amplification is generally achieved through nuclear reactions in the subcritical blanket surrounding plasma. Not only power could be produced in such a blanket, but also nuclear fuel, and waste of the nuclear fuel cycle could be disposed. The problem of systems using the thermonuclear reaction between deuterium and tritium lies in the lack of tritium reserves and in the limited possibilities of its production. Therefore, the work considers organization of a fuel cycle based on the deuterium-deuterium reaction. Options of a neutron source based on tokamak and linear system of the open trap type were examined. Magnitude of the socalled hybrid system electrical efficiency (ratio of the system electrical output to the blanket thermal power) was estimated. Calculations demonstrated fundamental possibility of realizing substantial neutron yield from deuterium plasma. To achieve acceptable performance, power gain in thermonuclear plasma should be Q = 0.5--1. In a tokamak of reasonable scale and when working on deuterium, the gain should be Q ~ 0.3. Potential advantages of linear systems associated with the possibility of high-pressure plasma confinement are presented