bluuebunny/crossref_metadata_2025 huggingface dataset:
“Genetic Profiling of Breast Cancer using cDNA Microarray.”
Authors: Modak Anirudh , Ghosh Dr. Tanaya , Basu Shamayita
Published: June 2022

Abstract: In defining the grade, stage, and residual determination of Breast Cancer and its subtypes, the molecular basis of analysis has become increasingly important. Vast-scale research studies have discovered a large number of genetic changes that cause the development and progression of breast cancer subtypes. Microarray and biotechnological approaches of hybridizationbased analysis and microtiter level evaluation have come a long way in determining the expression level of mutant or hereditary genes. For Genomic Research and Diagnostics, DNA Microarray analysis allows for the simultaneous investigation of thousands of DNA sequences. Breast cancer subtypes are distinguished by clusters of co-expressed genes discovered by the manipulation of mammary epithelial cells. The efficacy of a treatment is determined by the prognostic development of an individual patient. A comparison of gene expression levels in the Pre-treatment and Post-treatment stages has evolved into a concept that has the potential to change genetic dissection, drug development, disease diagnostics, and individualised therapeutic solutions. The goal of this review was to look into how to diagnose breast carcinomas using changes in gene expression patterns derived from cDNA microarrays and how to link tumour characteristics to clinical outcomes. Keywords: Breast Cancer, Genes, Mutations, Gene Expression, DNA Microarray, Microarray-Analysis
Phytoremediation Technology and How to Increase Phytoremediation Capacity of Plants
Authors: Shah Pragya
Published: June 2022

Abstract: Phytoremediation technology is the use of green plants for remediation of heavy metals and contaminants. Heavy metals like lead (Pb), cadmium (Cd), Chromium (Cr) affect the green plants. The use of EDTA (Ethylenediaaminetetra acetic acid) increases the Phytoremediation capacity of plants. Increases the metal uptake of plants. It also increases the Phytoextracting capacity of plants. EDTA increases the growth of plants and helpful in maintaining green vegetation. EDTA is a stong chelator, it remediate the heavy metal from polluted soil by making complex with metal. Keywords: Phytoremediation, EDTA, Phytoextraction, Plants, Chromium.
Design and Optimization Technique for Best Suited Solar Panel Cleaning System
Authors: Siddiqui Moien H.
Published: June 2022

Abstract: The project is about the design and development of a PV panel cleaning system. The main object of this design prototype is to clean the solar panel using an Automatic mechanism, such that efficiency or quality of solar panel is not compromised. If the cleaning is performed manually will be very costly and time consuming. This Solar Panel Cleaning Robot aims to maintain the efficiency of Solar power production by making sure the Solar panels are kept clean regularly. Keywords: Solar panel, Electrical Cleaning Mechanism, Rolling brush, Arduino board, DC Gear motor.
Authentication By Grid Image Pattern
Authors: K Raghul , V Thossi Bala , R Suriya Prakash , T N Sudhahar
Published: June 2022

Abstract: This paper tries to point out flashy topics in an authentication system that works by having the user select from images, in a specific pattern (order), presented in a Graphical User Interface (GUI). So that the graphical password approach is called Graphical Image Authentication (GIA). The most common authentication method is to use alpha-numerical passwords. For example user tends to choose passwords that can be easily guessed on the other hand, if a password is difficult to guess then it is often difficult to remember. To overcome this problem of low security, Authentication methods change from images to passwords. Because humans can remember visuals (patterns) better than text, graphical password schemes have been offered as a feasible replacement to text-based systems. Visual patterns, rather than specific images, are easier to remember.Patterns are general easier to remembered or recognized than text. This early study implies that many graphics in graphical password systems may support memorability. Keywords: Authentication, Pattern based authentication, Click points, Grid images, Graphical passwords
Influence of Discontinuous Diaphragm Characteristics on The Seismic Behaviour of Irregular RC Structure using ETABS
Authors: P Phadatare Pushpa , Vishwajeet Kadlag
Published: June 2022

Abstract: Researchers of past and present earthquake had damage to the R.C. structural buildings that fairly exposed to the damage and sudden breakdown of RC structure during lower and stronger ground motion. Diaphragm act as roof and roof system in concrete based reinforced building under seismic loading, these diaphragm transfers the series of lateral loads to the vertical members. In the present study, an seismic behaviour of irregular RC structures attempt is made study the behaviour of various parameters associated with diaphragm on the seismic behaviour of RC framed structure. Attempts are made to study the effect of discontinuities namely story displacement, story shears, with comparing seismic behaviour of irregular RC structures namely plus shaped with regular rectangle shaped multi storied building Keywords: Diaphragm discontinuity, story shear, story displacement, story drift, story stiffness, ETABS 2018
Cyberbullying Detection using Natural Language Processing
Authors: Rahman Md. Habeeb Ur
Published: June 2022

Abstract: Around the world, the use of the Internet and social media has increased exponentially, and they have become an integral part of daily life. It allows people to share their thoughts, feelings, and ideas with their loved ones through the Internet and social media. But with social networking sites becoming more popular, cyberbullying is on the rise. Using technology as a medium to bully someone is known as Cyberbullying. The Internet can be a source of abusive and harmful content and cause harm to others. Social networking sites provide a great medium for harassment, bullies, and youngsters who use these sites are vulnerable to attacks. Bullying can have long-term effects on adolescents’ ability to socialize and build lasting friendships Victims of cyberbullying often feel humiliated. social media users often can hide their identity, which helps misuse the available features. The use of offensive language has become one of the most popular issues on social networking. Text containing any form of abusive conduct that displays acts intended to hurt others is offensive language. Cyberbullying frequently leads to serious mental and physical distress, particularly for women and children, and sometimes forces them to commit suicide. The purpose of this project is to develop a technique that is effective to detect and avoid cyberbullying on social networking sites we are using Natural Language Processing and other machine learning algorithms. The dataset that we used for this project was collected from Kaggle, it contains data from Twitter that is then labeled to train the algorithm. Several classifiers are used to train and recognize bullying actions. The evaluation of the proposed Model for cyberbullying dataset shows that Logistic Regression performs better and achieves good accuracy than SVM, Ransom forest, Naive-Bayes, and Xgboost algorithm. Keywords: Cyberbullying, Machine learning, Natural language processing, Social media, Kaggle, Dataset.
Percepciones y conflictos humano-fauna en zona de amortiguamiento del Parque Internacional La Amistad, Costa Rica
Authors: Osorto-Nuñez Marco , Flores María Fernanda , Perez-Guevara María Camila , Coto-Sánchez Rebeca , Espinoza-Marín Carlos , Perucca Emilia , Rosero Estefanía , Vides-Hernández Gabriel , Esteves Juan , Aranda Alejandra
Published: June 2022

Introducción: Actualmente, muchos animales salen de las áreas silvestres protegidas en busca de recursos, sufriendo conflictos con las personas de áreas cercanas. Objetivo: Evaluar los conflictos entre personas y fauna en la Zona de Amortiguamiento del Parque Internacional La Amistad, Costa Rica. Métodos: Aplicamos entrevistas semiestructuradas y cuestionarios en cinco comunidades. Resultados: Las especies más conflictivas en agricultura fueron Ortalis cinereiceps, Atta cephalotes y Phyllophaga sp.; y en ganadería, Panthera onca, Desmodus rotundus y Canis latrans. Las pérdidas ascienden a US$44000, siendo Tres colinas y Santa María de Brunka las comunidades más afectadas, aunque sus habitantes presentan tanto opiniones positivas como negativas de estos animales. Conclusión: Seis especies causan la mayoría de las pérdidas en la zona, pero los habitantes difieren en cuanto a su percepción.
Patrones de actividad circadiana y lunar del jaguar y el puma en relación con sus presas y competidoras (Carnivora: Felidae)
Authors: Mooring Michael S. , Eppert Amy A.
Published: June 2022

Introducción: Los cambios temporales de nicho pueden amoldar las interacciones predador-presa al permitir a la presa evadir los predadores, mejorar la eficacia de la alimentación y reducir la competición entre predadores. Además de los patrones de actividad circadianos, el ciclo lunar mensual puede influye en los patrones de actividad nocturna de los mamíferos. Objetivo: Mediante muestreos con cámaras trampa en sitios de la pendiente del Pacífico y la Cordillera de Talamanca, investigamos los patrones de actividad circadiana (día y noche) y nocturna durante las fases de la luna del jaguar (Panthera onca) y puma (Puma concolor). Métodos: Investigamos la superposición y segregación temporal entre pares de cada predador y sus presas primarias, y entre sus competidores utilizando análisis de superposición, estadísticas circulares y abundancia relativa, teniendo en cuenta diferencias de hábitat, estaciones, y de impacto humano entre los sitios. Resultados: Nuestros resultados respaldaron la existencia de una separación temporal de nicho entre las dos especies de predadores, aunque ambos fueron clasificados como catemerales, el jaguar era principalmente diurno, mientras que el puma era principalmente nocturno. Descubrimos que el jaguar y el puma practican distintos patrones de actividad nocturna durante las fases de la luna, con el jaguar exhibiendo un aumento dramático en la actividad durante la luna llena y el puma manteniendo un nivel de actividad más consistente a través de las fases lunares. Sin embargo, durante la luna llena, ambas especies fueron más activas durante la noche y menos activas durante el día, lo que sugiere que practican un cambio de nicho temporal para aprovechar las actividades de caza durante la iluminación lunar más brillante de cada mes. Discutimos las presas primarias predichas y las especies competidoras.  Conclusión: Concluimos que el jaguar y el puma exhiben una separación de nicho significativa en actividad circadiana y lunar. A través de estos distintos patrones de actividad temporal, el jaguar y el puma pueden explotar una base de presas ligeramente diferente a pesar de su tamaño similar.
Viveros comunitarios de investigación en corredores biológicos del Área de Conservación La Amistad-Pacífico, Costa Rica
Authors: Seisdedos de Vergara Rocío , Cedeño-Fonseca Marco V. , López Mora Marco , López Mora Nancy , Altamirano Carrasco Elio , González-Maya José F. , Schipper Jan , Gómez-Hoyos Diego A.
Published: June 2022

Introducción: El Área de Conservación La Amistad-Pacífico incluye tres corredores biológicos que pueden beneficiarse de viveros de árboles nativos para la reforestación y permeabilización del paisaje. Objetivo: Probar una red de viveros comunitarios rentables apoyados por partes interesadas locales para garantizar la viabilidad a largo plazo y la restauración basada en evidencia. Métodos: Establecimos un vivero de referencia (>10 000 plántulas) y cuatro de pequeña escala (entre 163 y 1 600 plántulas). Recolectamos plántulas de 40 especies de árboles entre octubre de 2020 y junio de 2021 y las cuidamos a una altura adecuada, estimando la supervivencia de las especies con n ≥ 10. Resultados: la supervivencia media fue del 82 %, con 16 especies con una supervivencia ≥ 80 %. A las plántulas con cotiledones les fue mejor. Las razones para establecer viveros incluyen la atracción de abejas, la estética, la sombra, la madera, el alimento para la vida silvestre y la reforestación. Conclusión: Estos viveros de pequeña escala son viables y ayudan a las comunidades a mantenerse motivadas y estimar la supervivencia de las especies.
Conectividad estructural entre áreas prioritarias de conservación del Corredor Biológico Premontano Chirripó-Savegre, Costa Rica
Authors: Arias Navarro Adrián , Madrigal Villanueva Erick , Vargas Salazar Enzo
Published: June 2022

Introducción: La conectividad forestal estructural en corredores biológicos define el grado en que el paisaje facilita o dificulta el movimiento entre parches de recursos. Sin embargo, no existe información suficiente sobre este tema para el corredor Chirripó-Savegre. Objetivo: Evaluar la conectividad estructural de la posible ruta de enlace entre áreas prioritarias de conservación del Corredor Biológico Premontano Chirripó-Savegre, Costa Rica. Métodos: Definimos las áreas silvestres protegidas a conectar; identificamos nodos o núcleos de conexión prioritarios (parches de bosque); definimos los obstáculos (caminos, pueblos y suelos desprovistos de vegetación), distancia estimada a los cuerpos de agua protegidos por la ley; y modelamos la ruta de conectividad. Resultados: La ruta de conectividad estructural discurre entre las curvas de nivel sobre los 1.600 y 2.100 msnm, con seis puntos de intervención (pasos de fauna, reforestación o regeneración natural). Conclusión: Se puede desarrollar una ruta de conectividad estructural en el corredor Chirripó-Savegre.
Prescrições colonizadoras e sobrevoos possíveis sobre o currículo de história
Authors: Silva Guilherme Henrique da , Lucini Marizete
Published: June 2022

O presente artigo objetiva apresentar reflexões no âmbito do Ensino de História em diálogo com cenários vivenciados no exercício da docência, na disciplina de História, em uma escola pública do estado de São Paulo, no contexto da pandemia provocada pelo SARS-CoV-2, na modalidade do ensino remoto.  Para tanto, nos ancoramos em relatos coletados durante as aulas ministradas e estudos bibliográficos, no campo dos estudos de currículo e do ensino de História. Esta prática docente possibilitou problematizações entre o conteúdo ofertado em consonância com as diretrizes oficiais e seus desdobramentos entre os estudantes. Diante da relação entre o currículo oficial e os estudantes surgiu a questão central deste trabalho: discutir o lugar do Outro e da Diferença no currículo paulista durante a pandemia. Ao final, tais implicações nos direcionam a pensar que uma educação problematizadora produz alterações tanto na práxis docente, quanto no perfil dos estudantes, refletindo em uma sociedade democrática.
Os saberes profissionais dos pedagogos e as tecnologias digitais na Universidade Federal de Sergipe
Authors: Vasconcelos Alana , Ferrete Anne Alilma Silva Souza , Santos Willian Lima
Published: June 2022

Este artigo tem por objetivo problematizar a construção dos saberes profissionais sobre as Tecnologias Digitais de Informação e Comunicação (TDIC) no curso de Pedagogia da Universidade Federal de Sergipe. A partir de Tardif (2019) e compreendendo que o digital está inserido em todos os espaços da sociedade e, consequentemente na educação, investigar o itinerário formativo sobre TDIC dos docentes, discentes e dos egressos do curso torna-se essencial. Com isso, por meio de uma pesquisa qualitativa com viés exploratório, chega-se à consideração de que a apropriação das TDIC, intrínsecas à formação profissional do Pedagogo (universitária), não podem desprezar os saberes vivenciais ou experienciais, tendo em vista que a construção e mobilização dos saberes ocorrem no diálogo entre o Conhecimento Universitário, os Saberes Profissionais e os Saberes Docentes. Também foi possível perceber a emergente necessidade de políticas públicas para a integração das TDIC nos espaços formativos, para que os docentes e discentes possam diversificar as estratégias de ensino e aprendizagem.
SINGULAR PERTURBATIONS ARISING IN COMPLEX NEWTON'S METHOD
Authors: çilingir figen
Published: June 2022

We examine the resulting dynamics when Newton’s method is applied to
perturbations of polynomials that have a multiple root. Specifically, we
consider the case where Newton’s method is applied to the polynomial
family $(z^2 + c)(z-1)$.
Methods for detection of recent population subdivisions
Authors: O'Reilly Gabe , Frere Celine , Schultz Anthony , Kirkland Layla , Sherwin William
Published: June 2022

Potential subdivision events in populations can have a wide range of
causes: from natural disasters like bushfires that isolate communities,
to anthropogenic disturbances like infrastructure projects cutting
through a population’s habitat. Due to the unpredictability inherent in
events like bushfires, or even for predictable events such as property
development, populations affected by these potential subdivisions are
often not studied until after the event, making it extremely hard to
assess negative conservation impacts without the benefit of prior data.
This paper aims to apply population genetics methods to assess whether
it is possible to accurately assess the impact a potential subdivision
event can have on the genetic makeup of a population, especially when
one has no data prior to such an event. Differentiation measures, such
as Fst, might be used for detecting whether a population has been
subdivided. However, these measures often take dozens of generations to
show a significant change from zero (i.e., no differentiation),
especially in larger populations. In this paper we present a more
sensitive method, which is suitable for detecting subdivision effects
within a few generations of the event and which can be applied without
prior data. We test this method using both simulated data, and genetic
data from a population of koalas impacted by a railroad infrastructure
development.
Single center, multi-surgeon experience with a sutureless rapid deployment aortic valve prosthesis: A clinical and economic analysis in the United States
Authors: Ohlrich Kelly , Robich Michael P. , Raymer Catherine , Robaczewski David , Rabb Jaime , Radziszewski Dorothy J. , Iribarne Alexander , Seshasayee Shravanthi M. , Ross Cathy , Quinn Reed , Kramer Robert
Published: June 2022

Background The Perceval S is a sutureless, rapid deployment, bovine
pericardial aortic prosthesis on a nitinol stent, which has limited data
on outcomes and cost from the United States. Methods We performed a
retrospective review of Perceval S implantation at a single center
between 2015 and 2018. After exclusion criteria, we compared 262
patients who underwent sutureless aortic valve (SLV) implantation with
394 patients who underwent standard sutured aortic valves (SAVR).
Hospital cost data was reviewed, and risk adjustment, done by propensity
score and inverse probability weighting, was used to compare outcomes.
Results The SLV group was older, had more females, and had a higher
proportion of multicomponent operations. For isolated AVR, partial upper
hemisternotomy was more frequent in SLV. The median cardiopulmonary
bypass and cross clamp times for isolated SLV were significantly lower
than SAVR. SLV had a risk-adjusted 11.3% permanent pacemaker (PPM) rate
vs 6.1% in SAVR (p=0.016). There were no differences in other
postoperative complications (postoperative atrial fibrillation, stroke,
renal failure, prolonged ventilation; P>.05 for all).
Mortality at any time did not differ between groups. Median hospital
costs were higher in the SLV group, likely due to permanent pacemaker
rate leading to longer length of stay. Conclusion Sutureless tissue
aortic valves can be used safely with lower cardiopulmonary bypass and
clamp times than sutured prostheses and facilitate use of minimally
invasive approaches with cost neutrality. This valve may be advantageous
in older, higher risk patients requiring complex operations.
The crystal structures and chiral luminescence of three Iridium(III) complexes with the maximum EQE of 10.7% at 5000 cd/m2
Authors: Lu Junjian , Cheng Gan , Zhu Li-ya
Published: June 2022

In this paper, three Iridium(III) complexes, Ir(dnfppy)2(Cl/Pyrrole),
Ir(dfppy)2(dpp) and Ir(tfmqz)2(sdpp), have been designed and
synthesized. They emitted deep-blue, blue or red photoluminescence with
high quantum yields, for ((Ir(dnfppy)2(Cl/Pyrrole): λmax = 447 nm, F =
62.4%; Ir(dfppy)2(dpp): λmax = 467 nm, F = 25%; Ir(tfmqz)2(sdpp): λmax
= 609 nm, F = 73.7%), respectively. Two pairs of enantiomers of
Ir(dfppy)2(dpp) and Ir(tfmqz)2(sdpp) have been separated by column
chromatography. The maximum external quantum efficiency (EQEmax) of
OLEDs based on Ir(tfmpqz)2(sddp) was 13.8%, showing a relatively low
efficiency roll-off with the EQE of 10.7% at 5000 cd/m2.
Robot Hearing Through Optical Channel in a Cocktail Party Environment
Authors: Guo Xiao , Ding Siyi , Peng Ti , Li Kenan , Hong Xiaoping
Published: June 2022

The cocktail party problem refers to a challenging process when the
human sensory system tries to separate a specific voice from a loud
mixture of background sound sources. The problem is much more demanding
for machines and has become the holy grail in robotic hearing. Despite
the many advances in noise suppression, the intrinsic information from
the contaminated acoustic channel remains difficult to recover. Here we
show a simple-yet-powerful laser-assisted audio system termed REAL
(Robot Ear Accomplished by Laser) to probe the vibrations of
sound-carrying surfaces (mask, throat and other nearby surfaces) in
optical channel, which is intrinsically immune to acoustic background
noises. Our results demonstrate that REAL can directly obtain the
audio-frequency content from the laser without acoustic channel
interference. The signals can be further transcribed into
human-recognizable audio by exploiting the internal time and frequency
correlations through memory-enabled neural networks. The REAL system
would enable a new way in human-robot interaction.

Xiaoping Hong  Email:    hongxp@sustech.edu.cn
SILICA APPLICATIONS IN BIOMATERIALS: TEXTUAL REVIEW
Authors: Saciloto Vitoria De Godoy , Costa Susana Claudete , Silva Luciano da , Magnago Rachel Faverzani
Published: June 2022

Biomaterials are important tools for the reconstruction of organs and
tissues, and silica is widely used in these reconstruction technologies.
Hence, a lexical and content analysis was carried out on articles on
application of silica in biomaterials, based on a search in the Capes’
Journals Portal using the keywords “silica, biomedical, application,
scaffold”, between the years 2009 and 2019. The 110 selected articles
were analyzed using the IRaMuTeQ software, Word Cloud and Descending
Hierarchical Classification (DHC). The words: “silica, cell,
nanosilica, bone, material, scaffold and application” appear
prominently in the Word Cloud and DHC indicating four classes: (1)
physical characterization, (2) biomedicine applications, (3) engineering
applications and (4) compatibility characterization. Thus, the analysis
of DHC and Word Cloud showed that the main ways of using silica are:
mesoporous silica nanoparticles, amorphous silica, silica-based
materials, nanofibers and silica hybrids, and the main biomaterials
developed are scaffolds, grafts, aerogels, hydrogels, membranes and drug
delivery systems.
MeStudio: crossing methylation and genomic features for comparative epigenomic analyses
Authors: Riccardi Christopher , Passeri Iacopo , Cangioli Lisa , Fagorzi Camilla , Mengoni Alessio , Fondi Marco
Published: June 2022

DNA methylation is one of the most relevant epigenetic modifications. It
is present in eukaryotes and prokaryotes and is related to several
biological phenomena, including gene flow and adaptation to
environmental conditions. The widespread use of third-generation
sequencing technologies allows direct and easy detection of genome-wide
methylation profiles, offering increasing opportunities to understand
and exploit the epigenomics landscape of individuals and populations.
Here, we present MeStudio, a pipeline which allows to analyse and
combine genome-wide methylation profiles with genomic features. Outputs
report the presence of DNA methylation in coding sequences (CDS) and
noncoding sequences, including both intergenic sequences, and sequences
upstream to CDS. We show the usage and performances of MeStudio on a set
of single-molecule real time sequencing outputs from strains of the
bacterial species Sinorhizobium meliloti. MeStudio is freely available
under an open source GPLv3 license at
https://github.com/combogenomics/MeStudio
Guidance for dosing and monitoring of oral antineoplastic drugs in breast cancer patients after bariatric surgery
Authors: Kingma Jurjen , Peeters Niels , Knibbe Catherijne , Agterof Mariette , Derksen Wouter , Broek Marcel van den , Burgers Desirée
Published: June 2022

Bariatric surgery is a common applied surgical intervention in
individuals with obesity to achieve weight-loss, to reduce comorbidities
and improve overall survival. However, commonly performed techniques are
associated with physiological changes in the gastrointestinal tract that
may lead to changes in oral drug disposition. Furthermore, recommended
dietary restrictions after bariatric surgery might influence drug
disposition and due to prophylactic prescribed drugs interactions might
occur. Also, in the years after bariatric surgery, patients will lose
weight. These alterations can influence oral drug disposition of oral
antineoplastic drugs and, subsequently influence outcomes of breast
cancer treatment. The purpose of this review is to provide an overview
of the available evidence on the effect of bariatric surgery on the
pharmacokinetics of oral antineoplastic drug used in breast cancer
treatment. We performed a comprehensive analysis of published
pharmacokinetic and pharmacodynamics data. Subsequently we provide,
where possible, recommendations on preferences within therapeutic
classes and provide recommendations when prescribing oral antineoplastic
drugs for breast cancer. Due to the limited availability of clinical
evidence on oral drug disposition and subsequently outcomes in this
population, our advice is to monitor patients extensively for efficacy
but also for safety before and after surgery.
Assessment of efficacy of platelet-rich plasma application in regeneration of the facial nerve in rabbits
Authors: Gardasevic Milka , Petkovic-Curcin Aleksandra , Vojvodic Danilo , Marjanovic Uros , Djurdjevic Dragan , Jovic Sasa , Vulovic Dejan , Matijevic Stevo
Published: June 2022

Background/Aim. The injuries of the facial nerve lead to paralysis of the mimic musculature, which is conditioned by functional disorders accompanied by deformity of varying degrees depending on the intensity and location of the injury. Surgical treatment is a method of choice to treat an injured nerve. Injuries in the parotid lodge area are repaired by direct neurosuture in combination with platelet-rich plasma (PRP). Methods. The experimental study was carried out on 48 chinchilla male rabbits (Oryctolagus cuniculus), of about the same weight (2,500?3,000 gr), aged between 3 and 4 months in two surgical stages, in two different periods ? six and ten weeks after the first surgical procedure. The animals were divided into four groups: Group I (suture); Group II [suture and fibrin glue (FG)]; Group III (suture and PRP); Group IV (sutures, FG, and PRP). Each group had two subgroups based on the duration of the experiment (six and ten weeks). A part of the dissected nerve in the length of 5 mm was subjected to histologic verification, where the number of axons and Schwann cells was determined and expressed numerically based on the histological sample of the tissue of the observed nerve. The extent of the presence of connective tissue and the degree of neo-vascularisation is shown by the description of histological samples by grades (connective tissue 1-4, neovascularisation 1-3). Results. Our results showed that all parameters of re-generation of damaged nerve showed a significantly higher regeneration efficiency after six and ten weeks of intervention in groups treated with PRP therapy with or without using FG. Conclusion. The use of PRP and the stimulating effect of activated growth factors results in the regeneration of the facial nerve in the sense of replication of the Schwann cells and the number of axons, with a high degree of neovascularization and minimal proliferation of connective tissue, which histologically corresponds to a healthy nerve.
Influence of solvent use on apical extrusion during removal of Resilon™ from root canals
Authors: Vukoje Karolina , Veljovic Tanja , Mirnic Jelena , Maletin Aleksandra , Tadic Ana
Published: June 2022

Background/Aim. During retreatment, filling material and debris may extrude and trigger an inflammatory reaction of periapical tissues. Resilon? has not been investigated in terms of solvent use and influence on apical extrusion during retreatment. The aim of the study was to evaluate the amount of apically extruded debris during Resilon? removal using ProTaper (PT), Twisted File (TF), and Hedstrom instruments, with and without solvent. Methods. In total, 72 extracted teeth with single canals were used. Canals were prepared with PT Universal (F2) and filled with Resilon? and RealSeal sealer before being assigned randomly to 6 groups (n = 12 in each group). Retreatment in Groups 1?3 was done with PT, TF, or Hedstrom instruments, without solvent. In Groups 4?6, the same instruments were used with chloroform. Apically extruded debris was collected in a simulated periapical environment and assessed visually. Additionally, the time required for retreatment was recorded. Data were analyzed statistically using the Mann-Whitney U test, with a significance level of 0.05. Results. There were no significant differences in apical extrusion debris between groups (p > 0.05) regarding solvent use. Rotary instruments, without solvent, were associated with significantly less debris extrusion when compared with hand files (p < 0.05). When solvent was used, rotary instruments caused a higher degree of extruded material, which was similar to the results of hand instruments. Conclusion. The use of rotary instruments without solvent resulted in a lower degree extrusion of Resilon ? material compared to hand instruments, while greater caution is advised in the presence of solvent when rotary instruments are used to remove this material.
Effect of Staphylococcus aureus in experimental pneumonia mouse model on promotion of mBD-3 expression through activation of the ERK1/2 pathway
Authors: Ni Yongqing , Bi Xiaoduo , Zhao Pengwei
Published: June 2022

Background/Aim. Staphylococcus aureus (S. aureus) is a gram-positive pathogen that causes various human diseases. S. aureus causes pneumonia, which is characterized by localized tissue necrosis. The aim of the study was to explore the expression of mouse ?-defensin 3 (mBD-3) induced by S. aureus in mouse lungs and the effect of mBD-3 expression on the mitogen-activated protein kinase (MAPK) pathway. Methods. An experimental model of S. aureus pneumonia in mice was developed, and the expression of mBD-3 and activation of the MAPK pathway were investigated using the methods of immunofluorescence and western blot. Results. The experimental model was created successfully. The number of white blood cells was elevated 48 and 72 hrs after the introduction of bacteria through mouse airways, and bronchiolar mucosal hyperemia was observed, along with a large number of white blood cells and mucus in the bronchioles. The mBD-3 expression levels 48 and 72 hrs after the induction of infection were greater than the levels in the control group and 24 hrs after the induction. The amount of phosphorylated extracellular signal-regulated kinase (ERK1/2) was increased 48 and 72 hrs after infection induction, compared with the levels in the control group and 24 hrs after induction. The expression of mBD-3 was lower when ERK1/2 phosphorylation was inhibited by the U0126 inhibitor. Conclusion. S. aureus in experimental pneumonia mouse model accelerates mBD-3 expression in the mouse lung mainly through an ERK1/2-dependent signaling pathway.
Short-stay thyroid surgery for older patients, is it safe?
Authors: Kalezic Marko , Zivic Rastko , Djukic Vladimir , Milanovic Miljan , Ostojic Milkica , Rancic Nemanja , Vekic Berislav
Published: June 2022

Background/Aim. The incidence of nodular thyroid dis-ease increases significantly with age as well as the incidence and aggressiveness of thyroid cancers. The aim of the study was to determine whether thyroid surgery for geriatric patients is safe in a short hospital stay surgery set-ting. Methods. In this retrospective study, medical histories of all operated geriatric patients (65 years and older), in whom a total thyroidectomy (TT) or hemithyroidectomy (HT) was performed from January 2012 to December 2018, were analyzed. A total of 976 patients were operated on for thyroid diseases in the mentioned period, out of which 247 geriatric patients fulfilled the inclusion criteria. Patients with thyroid reoperations and simultaneous neck lymph node dissections were excluded from the study. The geriatric patients were divided into two groups: the HT group (33 patients) and the TT group (214 patients). Each of these two geriatric groups, HT and TT, had two additional paired control groups. Control group I consisted of younger subjects from 20?44 years, and control group II included middle-aged subjects from 45?64 years. Results. All three TT groups ? geriatric, control I, and control II, had 214 patients each, and all three HT groups had 33 patients each. In all three HT groups, the average hospital stay was 24 hrs, while in the TT geriatric group, 150 (70.1%) of 214 patients spent 24 hrs at the hospital. In the geriatric population, the incidence of neck swelling and in-creased drainage output were higher compared to both control groups, and thus the need for longer hospitalizations. When the age was compared, it was shown that sub-jects with each subsequent year of intervention had a 22% lower chance of developing complications, and regarding the pathohistological finding, benign thyroid hyperplasia was less likely to develop complications compared to malignant hyperplasia. Conclusion. According to the study, TT can be safely performed within the concept of a short hospital stay in patients under 65 years, while in the elder-ly, hospitalization days may be extended due to more frequent surgical and nonsurgical complications. Speaking of HT, the short hospital stay is safe for all age groups.
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF BERBASIS APLIKASI ANDROID PADA MATERI SISTEM IMUNITAS
Authors: Arofian Julsa , Sujarwanta Agus , Asih Triana
Published: June 2022

This research is a research and development research and development (R&D) that aims to develop interactive learning media in the immune system material based on android applications. The learning media developed in this study is a form of learning media innovation that is able to follow the modern era by utilizing the Android system through the Playstore feature. The product trial developed was carried out on students of class XI Science SMA N 1 Bandar Sribhawono, before the product trial was carried out a validation stage was carried out by a team of experts from the Muhammadiyah Metro University lecturer. Based on the data analysis, it was obtained that the overall percentage value of the expert team was 90.8%, so the media developed was included in the "very feasible" category for use. The product trial phase for students obtained results for the good category of 64.8% and the very good category of 27.4% so that the results obtained for the feasibility of the product were 92.2%. The results of these calculations can conclude that this android-based application is "very feasible" to be used in the learning process. Kata Kunci: android, Media Pembelajaran Interaktif Analisis Kebutuhan, Pengembangan
Principales retos de la profesión contable desde las perspectivas económica, digital y científica
Authors: González Montoya Camila , Puerta Castrillón Verónica Yulieth , Chamorro González Candy Lorena
Published: June 2022

El presente estudio identificó los principales retos de la profesión contable desde las perspectivas económica, digital y científica. Para ello, se utilizó un enfoque metodológico cualitativo con alcance descriptivo y método deductivo; las técnicas de investigación fueron revisión documental y aplicación de una entrevista semiestructura para obtener las apreciaciones de los profesionales contables en relación con el objeto de estudio. Los resultados reflejan que algunos retos son: análisis de inteligencia empresarial, detección de fraudes financieros, analítica de datos, competencias en blockchain, pensamiento crítico, gestión del conocimiento, consultoría de proyectos, servicios internacionales de contabilidad, entre otros. Se concluye así que la revolución económica, digital y científica impone diversos roles en el ejercicio profesional contable, los cuales variarán según las dinámicas futuras.
Safety monitoring of COVID-19 vaccination among adolescents aged 12 to 17 years old in the Republic of Korea
Authors: Kim Seontae , Hwang Insob , Ko Mijeong , Kwon Yunhyung , Lee Yeon-Kyeng
Published: June 2022

Objectives: This study aimed to disseminate information on coronavirus disease 2019 (COVID-19) vaccine safety among adolescents aged 12 to 17 years in the Republic of Korea.Methods: Two databases were used to assess COVID-19 vaccine safety in adolescents aged 12 to 17 years who completed the primary Pfizer-BioNTech vaccination series. Adverse events reported to the web-based COVID-19 vaccination management system (CVMS) and collected in the text message-based system were analyzed.Results: From March 5, 2021 to February 13, 2022, 12,216 adverse events among 12- to 17-year-olds were reported to theCVMS, of which 97.1% were non-serious adverse events and 2.9% were serious adverse events, including 85 suspected cases of anaphylaxis, 74 suspected cases of myocarditis and/or pericarditis, and 2 deaths. From December 13, 2021 to January 26, 2022, 10,389 adolescents responded to a text message survey, and local/systemic adverse events were more common after dose 2 than after dose 1. The most commonly reported events following either vaccine dose were pain at the injection site, headache, fatigue/tiredness, and myalgia.Conclusion: The overall results are consistent with safety data reported in the United States and a controlled trial and serious adverse.events were rare among adolescents aged 12 to 17 years following COVID-19 vaccination.
SISTEM INFORMASI GEOGRAFIS PENCARIAN LOKASI PERUSAHAAN MEBEL TERDEKAT DI JEPARA DENGAN METODE ALGORITMA A*(STAR) BERBASIS WEB
Authors: Saputro Heru
Published: June 2022

Sentra kerajinan mebel merupakan tempat untuk menjual berbagai macam jenis produk mebel. Di Kabupaten Jepara terdapat banyak sekali senta kerajinan mebel, dimana warga maupun wisatawan tidak mengetahui lokasi sentra kerajinan mebel yang sesuai dengan jenis produk mebel yang dibutuhkan. Hal ini menyulitkan warga maupun wisatawan untuk mencari produk mebel yang ingin dicari. Untuk mengatasi hal tersebut dibuatkan Sistem Informasi Geografis yang dapat menampilkan lokasi sentra mebel di Kabupaten Jepara dan juga dapat menentukan rute terpendek dari lokasi titik awal ke lokasi titik tujuan. Sistem Informasi Geografis tersebut dibuat dengan metode Algoritma A*(Star). Algoritma A*(Star) merupakan algoritma yang mencari rute terpendek dari lokasi titik awal (starting point) menuju lokasi titik tujuan yang mengacu pada harga (f) terkecil. Diharapkan pengguna dapat  menemukan informasi dengan mudah mengenai lokasi sentra mebel di Kabupaten Jepara.
PERANCANGAN SISTEM INFORMASI PENGELOLAAN TOKO MEBEL BERBASIS MOBILE
Authors: Triyanto Wiwit Agus , Murti Alif Catur
Published: June 2022

Toko Mebel yang merupakan perusahaan bergerak dalam bidang Furniture semakin hari semakin berkembang dalam mengerjakan proyek pengadaan dari instansi pemerintahan, swasta ataupun perorangan. Namun, pemanfaatan teknologi informasi yang digunakan tergolong masih kurang baik karena belum memaksimalkan sistem terkomputerisasi yang digunakan dalam proses pengelolaan mebel. Dari permasalahan tersebut, dirancanglah sistem informasi pengelolaan toko mebel berbasis android yang nantinya digunakan untuk mempermudah pengelolaan manajemen toko mebel, dari mulai pendataan bahan baku sampai pelaporan pemesanan. Informasi atau hasil yang diperoleh dari sistem ini berupa laporan data manajemen mebel, laporan manajemen secara harian dan berkala secara bulanan dan tahunan.
ANALISIS SENTIMEN TERHADAP XIAOMI INDONESIA MENGGUNAKAN METODE NAÏVE BAYES
Authors: Utami Ranita Wahyu , Jazuli Ahmad , Khotimah Tutik
Published: June 2022

Seiring berkembangnya teknologi, hampir seluruh aspek kehidupan manusia menggunakan teknologi untuk membantu tugasnya. Peran teknologi pada pekerjaan, dunia Pendidikan, maupun sebagai hiburan. Salah satu perusahaan elektronik yang digandrungi masyarakat adalah brand Xiaomi. Penelitian ini bertujuan untuk mengetahui sentimen masyarakat terhadap brand Xiaomi menggunakan metode Naïve Bayes Classifier (NBC). Penelitian ini mengambil data dari media sosial twitter menggunakan teknik scrapping sebanyak 2.078 data tweet. Dalam proses analisis ini menggunakan library text bloob untuk mendapatkan labelling otomatis dari data tweet. Berdasarkan hasil penelitian, analisis sentimen terhadap brand Xiaomi mendapatkan akurasi sebesar 71.88% dengan data polaritas positif 39%, polaritas netral 51%, dan polaritas negatif sebesar 10%.
Research on the Teaching Task Design of “Reading Circles” in Senior High School Aiming at the Cultivation of Critical Thinking Ability
Authors: Yaxuan Sun , Hong Yun
Published: June 2022

Critical thinking ability is an important element of thinking ability under the core competence of English discipline. Combined with “Reading Circles”, a kind of group-based and student-centered reading activity, this paper explores the relationship between “Reading Circles” and four critical thinking abilities: focus and definition, analysis and evaluation, reasoning and demonstration, review and correction. Taking the “Reading Circles” task design in The Million Pound Bank Note as an example, this paper expounds the high school teaching design aiming at the students’ cultivation of critical thinking which provides a specific and operable practical example for the development of English “Reading Circles" course in senior high school.
Recommendations for an improved referral system for specialized glaucoma clinics in Poland
Authors: Choręziak Aneta , Brązert Agata , Borys Aleksandra , Gotz-Więckowska Anna
Published: June 2022

This study assessed the quality of referral letters to the Glaucoma Outpatient Clinic and patients’ first consultation results. A retrospective study included 196 patients newly referred to the clinic. Referrals were mainly issued by ophthalmologists (156; 79.6%). Regarding their urgency level, the planned referrals (184; 93.9%) were dominant. The majority of referral diagnoses (147; 75%) were confirmed as glaucoma in the clinic, whereas 17 (8.2%) glaucoma diagnoses were rejected. 64 (32.7%) patients did not require further ophthalmological review. The assessment of the quality of referral letters revealed that important clinical data was missing. There is a need to improve the referral system to specialist glaucoma clinics in Poland.
Ptosis – diagnostics and treatment
Authors: Jacuński Mateusz , Białas Dominika , Różycki Radosław
Published: June 2022

It is estimated that the low position of the upper eyelid affects over 1 million patients in Poland. Ptosis limits the visual field, causes compensatory head positions and the feeling of visual deterioration. The unaesthetic appearance of the eyes additionally contributes to low self-esteem. The aim of this article is to review modern diagnostic algorithms used in the case of a dropped eyelid. The paper also discusses the surgical techniques that are used in the case of ptosis and the guidelines for the correct qualification of the patient to a given surgical method.
Stroke risk scores for prediction of mortality and hemorrhages in atrial fibrillation patients
Authors: Ivănescu Andreea Cristina , Delcea Caterina , Dan Gheorghe Andrei
Published: June 2022

Background: Atrial fibrillation (AF) is an emerging epidemic worldwide, responsible for a twofold increase in mortality, independent of other risk factors. Stroke prevention is the cornerstone of AF management. However, oral anticoagulation imposes an increased risk of bleeding. Several risk scores have been developed for estimating both the thromboembolic and the bleeding risks. The aim of the study was to determine the usefulness of different stroke risk scores as predictors of mortality and hemorrhagic events in AF patients.

Methods: We retrospectively enrolled 211 AF patients hospitalized in the Cardiology Ward of our tertiary hospital. The primary endpoints were mortality and non-minor bleeding events. The mean follow-up period was 378 days for bleeding events and 5 years and 1 month for mortality. For each patient, we evaluated the following stroke risk scores: CHADS2, CHA2DS2-VASc, R2CHADS2, ABC, ATRIA, GARFIELD.

Results: The mean age in our cohort is 66, with a slight predominance of women (52.2%). For a CHA2DS2-VASc ≥ 4 as well as for a score of 2-3, 5-year survival was worse than for patients with a score of 0–1(chi-squared=8.13; p=0.01). Similarly, all subgroups of patients with an ABC <2%, had a worse 5-year survival when compared with an ABC score of ≥2% (chi-squared=12.85; p=0.005). C-statistics show a modest predictive value for mortality, for all stroke scores except Garfield, with similar AUCs, the highest being for CHA2DS2-VASc (AUC 0.656; p=0.0001). CHA2DS2-VASc also correlates with bleeding events, having a good predictive ability (AUC 0.723; 95%CI 0.658–0.782, p=0.001), mildly superior to HAS-BLED (AUC 0.674; 95% CI 0.523–0.825; p = 0.04) and very close to Garfield-bleeding (0.765; 95%CI 0.702–0.80; p=0.0001).

Conclusions: CHA2DS2-VASc is comparable to HAS-BLED and Garfield-bleeding in predicting bleeding events in AF patients. CHA2DS2-VASc and ABC correlate directly and consistently with mortality rate. For CHA2DS2-VASc, the AUCs for our endpoints are similar to the ones for stroke prediction, highlighting the potential of extending its applicability to various outcomes.
FAKTOR-FAKTOR YANG MELATARBELAKANGI KEPUTUSAN KONSUMEN MENGGUNAKAN JASA LAYANAN GRABFOOD PADA APLIKASI GRAB DI KOTA DENPASAR
Authors: SETIAWATI NI KADEK , SUKARSA I KOMANG GDE , GANDHIADI G.K. , KENCANA I PUTU EKA NILA
Published: June 2022

Grabfood is one type of online food delivery services. This services can be an alternative when people want to buy foods or drinks but cannot leave their activities. Knowing the consumer’s decision to use Grabfood is important because it such one of effort to improve the quality of this services. This research is aimed to determine factors behind consumer’s decision for using Grabfood services on the Grab application in Denpasar City. The method used in this research is factor analysis by analyzing the assessment of 120 respondents whom domiciled in Denpasar City and have used Grabfood services at least three times a month. Based on the results, there were five factors behind consumer’s decision for using Grabfood services in Denpasar City. Those factors are reliability factor of drivers, the ease of obtaining orders, informative and responsive factors for consumers, order assurance factors, and consumer care and understanding factors. Those five factors were able to explain the factors behind consumer’s decision for using Grabfood service on the Grab application in Denpasar City by 63.99%.