bluuebunny/crossref_metadata_2025 huggingface dataset:
A Importância da Espiritualidade como construtora do processo de Individuação
Authors: Santos Michelle Steiner dos , Alencar Lucileide Leila Tavares Vale , Jesuino Filipe de Menezes , Silva Arnislane Nogueira
Published: July 2021

Considerando a espiritualidade como importante componente da constituição psicológica dos seres humanos, sendo estudada em vários contextos e por vários pesquisadores, este trabalho investigou possíveis relações da espiritualidade com a saúde, embasando-se na Psicologia Analítica para leitura do fenômeno. O método utilizado na investigação foi a pesquisa bibliográfica e análise teórica de literatura junguiana e não junguiana relacionada à temática. Compreende-se espiritualidade como uma busca pessoal pelo sentido da vida, podendo estar relacionada ao sagrado e ao transcendente. Religião é entendida como um conjunto organizado de crenças, ritos e símbolos que podem ou não promover o contato com o sagrado e o transcendente.  Jung não se refere explicitamente ao termo espiritualidade, mas este aparece imbricado em sua obra, especialmente quando ele discorre sobre religião e confissão. Por fim, aborda-se a necessidade de se estudar e discutir a espiritualidade na graduação em psicologia e considerá-la pertinente ao processo psicoterapêutico, sem a adoção de uma postura negligente sobre o fenômeno espiritualidade e processo de individuação.

Palavras-Chave: Espiritualidade; Individuação; Psicologia Analítica.
Relato de experiência de um Serviço de Emergência do interior do Rio de Janeiro com a Pandemia de COVID-19
Authors: Magrani Gefson Couto , Bandeira Lívia Liberata Barbosa , Santos Sara Cristine Marques dos , Silva Carolina de Paula Orioli da , Trajano Eduardo Tavares Lima , Aragão Ivana Picone Borges de
Published: July 2021

A pandemia causada pelo COVID-19 é atualmente um problema de saúde pública internacional. Trata-se de um vírus altamente transmissível, através de pessoas sintomáticas, por contato com aerossóis e uso de objetos compartilhados. A sintomatologia mais prevalente tem a apresentação de febre, dor de garganta e tosse. O presente estudo teve como objetivo relatar a experiência na “linha de frente”, como diretor médico da UPA no interior do Rio de Janeiro, no enfrentamento da pandemia, onde foi preciso realizar a orientação em relação as medidas preventivas aos trabalhadores do sistema de saúde e a população em geral. Houve a implantação de fluxogramas de atendimento e detecção precoce para acolhimento do paciente com suspeita de COVID. Tal medida, possibilitou maior controle sobre as ações realizadas, com taxa de mortalidade menor que a média nacional e recuperação em 85% dos casos.

Palavras-chave: Infecções por Coronavirus; Betacoronavirus; Vírus da SARS
Eficácia de tocilizumabe para pacientes com COVID-19: revisão sistemática de literatura
Authors: Sobrinho Alberto Guimarães Medrado , Silva Marco Aurélio dos Santos
Published: July 2021

Estudos têm revelado que pacientes com COVID-19 tratados com tocilizumabe têm reduzido os níveis de IL-6. Este estudo tem como objetivo realizar uma revisão sobre a eficácia do tocilizumabe no tratamento da COVD-19. Esta revisão contou com artigos publicados nos idiomas português e inglês de janeiro a dezembro de 2020, disponíveis nas bases de dados da Biblioteca Virtual em Saúde (BVS) e PubMed. A busca nas bases de dados resultou em 1191 referências, 502 na Biblioteca Virtual em Saúde (BVS) e 689 na PubMed. Ao serem aplicados os critérios de inclusão e exclusão, 24 estudos preencheram os critérios necessários à realização desta revisão. A única publicação disponível em português foi excluída por se tratar de Diretrizes para o tratamento farmacológico da COVID-19. A maioria dos estudos analisados sugere que o uso de tocilizumabe no tratamento de pacientes em estado grave ou crítico com COVID-19, tem contribuído para melhoria do estado clínico, com redução de citocinas e da resposta inflamatória. Nos estudos em que foram comparados grupos de pacientes com tratamento padrão com grupos de pacientes que receberam tocilizumabe, os resultados também mostram maiores desfechos favoráveis entre os grupos tocilizumabe. Conclui-se que, apesar desses resultados, seriam necessários mais estudos envolvendo um número maior de pacientes para confirmar a eficácia e a segurança do tocilizumabe em pacientes com COVID 19.

Palavras-chave: Coronavirus; Covid-19; Tratamento; Tocilizumabe.
Age-related Differences in Mu Rhythm During Emotional Destination Memory Task
Authors: Kladi Anastasia , Iliadou Paraskevi , Tsolaki Magdalini , Moraitou Despoina
Published: July 2021

Background:

Destination memory defined as the ability to remember to whom we addressed
a piece of information is found to be impaired in normal aging. Theories of affect development
and research findings have shown that emotional charging improves performance on memory
tasks, and also that Mu rhythm is desynchronized as an index of mirror neuron activation during
such tasks.

Objective:

In this paper, we sought to investigate the differences in Mu rhythm during an emotional
destination memory task, between younger and older adults.

Methods:

16 cognitively normal older adults, recruited from Alzheimer’s disease day center and 16
young adults, recruited via advertisements, participated in this experimental study. We investigated
destination memory of emotionally charged faces (Emotional Destination Memory, EDM) while applying
electroencephalograph (EEG) in real time in young versus older adults. We measured Mu
rhythm in frontal, fronto-temporal and central areas. EEG data has been pre-processed, segmented
in non-overlapping epochs, and independent component analysis (ICA) has been conducted to reject
artifacts.

Results:

Results showed that young adults performed better than older adults in remembering facts
associated with angry faces. Also, different neurophysiological activation was found, with older
adults showing Mu suppression in frontal and fronto-temporal regions, specifically in F3, F7 and
F8 electrodes, in contrast with young adults who showed Mu enhancement. Regarding within
group differences, it was found that in the older adults group, electrodes F8 and central C3 were
the most activated, while in the young adults group, C3 was the most activated electrode.

Conclusion:

The findings suggest better behavioral performance of young adults as a result of better
cognitive state and adaptive bias. On a neurophysiological level, it is suggested that older adults
employ Mu suppression, thus possible activation of mirror neurons, as a compensatory mechanism
while mirroring properties are not spontaneously activated in young adults.
Enfoque espacial para modelación de carbono en el mantillo de bosques bajo manejo forestal maderable
Authors: Pérez-Vázquez Zaira Rosario , Ángeles-Pérez Gregorio , Chávez-Vergara Bruno , Valdez-Lazalde José René , Ramírez-Guzmán Martha Elva
Published: July 2021

El piso forestal o mantillo es el almacén de carbono que regula la mayoría de los procesos funcionales de los ecosistemas forestales, influyendo directamente en la fertilidad del suelo y en la productividad del sitio. El contenido de carbono en el piso forestal es altamente variable en espacio y tiempo; por ello, obtener evaluaciones precisas del carbono contenido en este almacén representa un desafío metodológico importante a cualquier escala. En este estudio, se compararon cuatro métodos de modelación espacial para mapear el contenido de carbono en el piso forestal de un bosque templado. Los métodos fueron kriging ordinario, modelo lineal generalizado, modelo aditivo generalizado y random forest. Las estimaciones del contenido de carbono fueron realizadas para 2013 y 2018. Las variables predictoras representan la estructura espacial, del dosel y topográfica presente en el área de estudio. Todos los modelos fueron evaluados mediante validación cruzada y se determinó el error medio absoluto, el error cuadrático medio y el coeficiente de determinación. El desempeño de los métodos fue, en orden decreciente: random forest, modelo aditivo generalizado, modelo lineal generalizado y kriging ordinario. El método kriging ordinario reflejó el grado de dependencia espacial del contenido de carbono, pero las estimaciones espaciales fueron poco realistas (R2 ≤ 0.35). El modelo aditivo generalizado y el modelo lineal generalizado mostraron buen desempeño (R2 ≥ 0.70), pero mayor sobreestimación; random forest obtuvo el mejor ajuste (R2 ≥ 0.86) para modelar contenido de carbono en ambos años evaluados. Se concluye que random forest es un método prometedor, con gran potencial para mejorar las estimaciones de carbono en el mantillo a escala de paisaje.
CLASS G AUTOANTIBODIES TO OXIDATIVELY MODIFIED LOW DENSITY LIPOPROTEIN IN TYPE 2 DIABETES MELLITUS PATIENTS WHO HAVE HAD NON-Q-MYOCARDIAL INFARCTION
Authors: Altunina N. V. , Lizogub V. G. , Bondarchuk O. N.
Published: July 2021

The article presents the results of a study of class G autoantibodies to oxidatively modified low-density lipoprotein (ox-LDL) in patients with type 2 diabetes mellitus which have had non-Qmyocardial infarction and their connection with disturbances of carbohydrate and lipid metabolism, the levels of cytokines. It was identified the decrease level of IgG to ox-LDL in the serum of these patients compared with the control group and patients without diabetes. The study found that with increasing degree of insulin resistance, the concentration of class G autoantibodies to ox-LDL in diabetic postinfarction patients was reduced. It was also revealed their direct connection with the level of anti-inflammatory IL-10. The data obtained may be evidence of the negative impact of carbohydrate metabolism disorders on the level of IgG autoantibodies to ox-LDL and the data may refer to their protective role in type 2 diabetes mellitus with concomitant atherosclerosis.
ROLE OF OXIDATIVE STRESS AND CARBOHYDRATE METABOLISM IN THE HEART AND VASCULAR REMODELING IN PATIENTS WITH ARTERIAL HYPERTENSION ASSOCIATED WITH TYPE 2 DIABETES MELLITUS
Authors: Kochyeva M. M. , Radzishevska Ya. K. , Radzishevska Ie. B. , Linska G. V.
Published: July 2021

In the previous stages of research four integrated ultrasound parameters of heart and blood vessels state (factors) were proposed using the method of factor analysis. These factors had been defined as a linear combination of traditional ultrasound fourteen indicators. In the proposed paper the canonical correlations of these factors with three sets of laboratory indicators of oxidative stress, antioxidant defense, carbohydrate metabolism and existence of mutually directed multivariate correlations between them had been studied. The violation of carbohydrate metabolism was an integral part of the heart and vascular remodeling in patients with arterial hypertension associated with type 2 diabetes mellitus. To improve the diagnostic of antioxidant defense the definition the total antioxidant activity of red blood cells is advisable. Pathogenetically reasonable use of medicines with antioxidant properties was grounded.
FEATURES OF IMMUNOINFLAMMATORY ACTIVATION AND ENDOTHELIAL FUNCTION IN PATIENTS WITH CORONARY HEART DISEASE ASSOCIATED WITH HYPOTHYROIDISM
Authors: Mykhailovska N. S. , Oleynik T. V.
Published: July 2021

he presence of hypothyroidism in patients with coronary heart disease contributes to its progression. It was found that in patients with coronary heart disease associated with hypothyroidism, there is an increase markers of immunoinflammatory activation and endothelial dysfunction compared both to coronary heart disease patients without concomitant thyroid disease and patients with coronary artery disease with the structural changes of the thyroid gland in euthyroid state. Established the presence of correlations of neopterin levels, plasminogen activator inhibitor-1, endothelin-1 with hormones of the pituitary-thyroid level in patients with coronary heart disease with concomitant hypothyroidism.
CHARACTERISTICS OF WATER-SOLUBLE AND LIPOSOMAL QUERCETINE ON THE WEIGHT MEASURING VALUES, CARDIAC INTERVALOGRAM PARAMETERS AND TOLERANCE TO PHYSICAL LOAD OF ANIMALS IN TYPE 2 DIABETES MELLITUS WITH CONCOMITANT OBESITY
Authors: Stechyshyn I. P.
Published: July 2021

The model of type 2 diabetes mellitus with concomitant obesity (single injection of streptozotocine, 30 mg/kg, after four-week keeping on high-fat diet) provided a basis for the study of water-soluble and liposomal quercetine efficacy (10 mg/kg, introduction starting 10 weeks after streptozotocine injection and lasting 14 days). Body weight and heart weight changes as well as the correlation of the values (heart weight ratio) were investigated. The exercise tolerance was determined through swimming test and cardiac intervalography was registered. Body weight as well as heart weight and heart weight ratio were found to grow in the animals with type 2 diabetes mellitus and concomitant obesity, whereas the exercise tolerance was found to decrease. Cardiac intervalogram findings revealed disbalanced parasympathetic and sympathetic influence on the heart and insufficient centralization of cardiac rhythm control. Drug injection was found to contribute to the improvement of weight measuring values, exercise tolerance and keeping the balance of cardiac intervalography values. The liposomal quercetine form was found to possess higher efficacy, as compared with the water-soluble one.
TESTOSTERONE REPLACEMENT THERAPY IN MEN WITH TYPE 2 DIABETES AND FAILURE TESTOSTERONE SYNDROME
Authors: Luchitskiy V. Ye. , Luchitskiy Ye. V. , Tronko M. D.
Published: July 2021

It was studied the influence of testosterone replacement therapy with prolonged action on thefunctional state of the pituitary-genital system, clinical symptoms of androgendeficiency in patientswith type 2 diabetes (DMt2) with androgendeficiency. The study involved 35 male patients with DMt2aged 39–72 years, duration of diabetes 2–14 years and total testosterone (T) levels < 10.4 nmol/l.For the purpose of replacement testosterone treatment was used (1000 mg) of the oil solution oftestosterone undecanoate. After 3 and 6 months after initiation of treatment there was a significantincrease in total testosterone concentration 14.6 ± 0.9 nmol/l and 17.0 ± 0.7 nmol/l, respectively vs8.3 ± 0.5 nmol/l before treatment (p < 0.05). Changes in the average levels of estradiol and lutropinduring treatment were not observed. No clinically significant side effects were not detected. Takinglong-acting testosterone undecanoate injection led to normalization of the total testosterone levelsand improve erectile function in men with type 2 diabetes and androgendeficiency.
THE EFFECT OF FLAVONOIDS ON HORMONAL BACKGROUND CHANGES IN EXPERIMENTAL METABOLIC SYNDROME
Authors: Zagayko A. L. , Briukhanova T. O. , Shkapo A. I.
Published: July 2021

It was established the experimental metabolic syndrome development in males of Syrian Golden hamsters on the background of the hypercaloric diet for 5 weeks. Pathological changes of metabolic links manifested by insulin resistance, a decrease in the content of adiponectin, hypercortisolaemia, leptinresistance and imbalance of sex hormones. The administration of the investigated compounds — quercetin and epigallocatechin gallate largely correct these changes. Epigallocatechin gallate had more expressive effect than quercetin.
ASSESSMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE RISK IN PATIENTS WITH TYPE 2 DIABETES MELLITUS BY LEPTINE AND TRIGLYCERIDE LEVELS (mathemathic model)
Authors: Plohotnichenko O. A. , Gorshunska M. Y. , Tyzhnenko T. V. , Krasova N. S. , Leshchenko Zh. A. , Gladkih A. I. , Poltorak V. V.
Published: July 2021

It was examined repeatedly patients with type 2 diabetes mellitus at the age within 33 and 65 years. It was established a significant increase in leptin and triglyceride levels in group of patients with non-alcoholic fatty liver disease. These indicators can be used as prognostic factors for the pathology risk assessment. Discriminant analysis with calculation of sensitivity, specificity, prognostic value of the positive and negative results and the accuracy index was conducted. It has been developed the diagnostic model for the identification of individuals with non-alcoholic fatty liver disease development risk among the type 2 diabetic patients based on the combined pattern of triglyceridemia and leptinemia, which will improve the quality of diagnosis and forming groups for preventive therapy.
PATHOGENETIC ASPECTS OF THE INTERMITTENT OF THE DEVELOPMENT OF THE POLYCYSTIC OVARY SYNDROME WITH PROLONGED COLD INFLUENCES IN THE EXPERIMENT
Authors: Kuzmina I. U. , Zhulikova M. V.
Published: July 2021

The aim of the research was to study the effect of intermittent cold effects (ICE) on the experimentally induced polycystic ovary syndrome (PCOS) in female rats to prevent the development of polycystic ovaries and elaboration the pathogenesis of its development. Simulation of PCOS was performed by subcutaneous injection of dehydroepiandrosterone acetate (DHEA) in rats for 25 days. A ICE was carried out by daily keeping the animals for 4 hours in a chamber in which the light regime and a temperature of + 4 °C were maintained. As a result of the experiments, it has been proved that after intracellular adaptive-compensatory reactions are activated in the ovarian tissue, which helps prevent the development of PCOS. In addition, ICE leads to an increase in the level of adipocytokines (adiponectin and leptin), which can indirectly affect the secretion of reproduction hormones and inhibit the development of cystic changes in the ovary. Stimulation of adaptive physiological reactions against the background of ICE blocks the development of signs of PCOS in rats.
SCREENING OF HORMONE – PRODUCING PITUITARY ADENOMAS (review of literature and own data)
Authors: Khizhnyak O. O. , Mikityuk M. R. , Barabash N. E. , Nikolaev R. S. , Manskaya E. H.
Published: July 2021

The article substantiates the need to screen adults of different age groups for early (preclinical) detection of such a rare pathology as acromegaly. Survey and treatment of patients with acromegaly is economically costly for both patients and the state as a whole, and therefore it is proposed screening of this pathology in the risk group using a questionnaire developed at the Department of age-related endocrinology of the «V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Sciences of Ukraine» on the basis of own experience in diagnosis and treatment of patients with acromegaly. The questionnaire is divided into two blocks, which include phenotypic features and signs associated with the development of metabolic and systemic complications.
Frequency of combinations of different histological forms of papillary thyroid cancer with other diseases of the thyroid parenchyma
Authors: Karachentsev Yu. I. , Dubovik V. M. , Gopkalova I. V. , Khaziev V. V. , Goydenko N. I. , Korchagin Y. P. , Sazonov M. Y. , Gerasimenko L. V.
Published: July 2021

The authors showed that in the prevailing majority of cases (71 %) papillary carcinomas were formed against the background of other thyroid diseases. In this work, the main forms of thyroid pathology, which is most often found in PTC, were identified and their frequency was determined. It has been proven that in 39.8 % of cases PTC was combined with only one of the following diseases: in 20 % with autoimmune thyroiditis, in 14.8 % with colloid goiter, in 5 % with follicular adenomas. The combination of PTC with not one, but with several thyroid pathologies is 31.4 %. Such a high frequency of combination of malignant and benign pathology in the thyroid gland suggests that the proliferative processes that result in benign diseases can change their direction and lead to the appearance of cells with signs of malignancy. That is, goitre-altered thyroid tissue is more sensitive to the action of various carcinogenic agents, such as radiation, toxic effects or impaired neuroendocrine regulation. In the analysis of histological forms of PTC, it was shown that AIT is more common in adenocarcinomas and PC from cylindrical cells, and colloid goiter in microscopic cancer and follicular PC. Follicular adenoma is more often associated with follicular PTC. We believe that the analysis will have value for the differential diagnosis of histological forms of papillary thyroid cancer.
COMPLE X TRE ATMENT OF OSTEOPOROSIS IN PATIENTS WITH 2 T YPE DIABETES MELLITUS IN COMBINATION WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Titova Ju. A.
Published: July 2021

An actual problem of modernity is the relationship between type 2 diabetes mellitus (DM) and osteoporosis(OP), as well as type 2 DM with non-alcoholic fatty liver disease (NAFLD), which are actively considered by scientists.There are different data on the development and course of OP, depending on gender, age and race. So theaim of the study was to determine the tactics of treatment of OP in patients with type 2 DM with NAFLD. 37patients with type 2 DM with OP and NAFLD (15 men and 22 women) were examined and treated. When examiningpatients with type 2 DM with OP and NAFLD before treatment, there was a deficiency of vitamin D, thatis, none of the patients had an adequate supply of vitamin D, while the indicators of the level of CA were in thenormal range, and the indicators of Ca++ were reduced, so they were prescribed therapy with magnesium, vitaminD, calcium in daily doses, depending on gender, age, revealed pathology and laboratory abnormalities, andall patients received individually selected therapy with sugar-lowering. To assess the degree of compensationof carbohydrate metabolism was carried out to study the level of glycosylated hemoglobin (HbA1c) and furthercorrection zakreslajac therapy. According to the results of the study, the expediency of prescribing drugs that affectthe improvement of bone structure in patients with type 2 DM with OP in daily doses depending on gender,age, degree of detected violations and deviations of laboratory parameters was proved, and it was determinedthat the improvement of bone tissue has a positive effect on the compensation of carbohydrate metabolism in theexamined patients. It was found that patients with type 2 DM with OP and NAFLD require monitoring withdensitometry and laboratory diagnosis in dynamics against the background of treatment.
Prostate-protective action of combined composition suppositories with indole-3-carbinol and meloxicam on model of sulpiride-induced benign prosate hyperplasia
Authors: Zaychenko G. , Ravshanov T.
Published: July 2021

Benign prostatic hyperplasia in rats after chronic administration of sulpiride was corrected by administration (rectal suppositories) containing indole-3-carbinol and meloxicam. Established that suppositories correct the mass coefficients of the sex glands, the degree of androgenization of the organism of male rats, positively effect on concentration of fructose in seminal vesicles, activity of phosphatases and function of urinary system. Suppositories do not have a gonadotoxic effect, contribute to normalization of the hormonal function of testes with improving of spermatogenesis. A significant decrease of pathological changes in the gland at cellular level revealed: normalization of 5α-reductase activity, concentration of sex hormone receptors, as result of the specific activity of active ingredient of suppositories - indol-3-carbinol. The expressive prostate-protective action of the combined composition suppositories exceeds such a reference preparation – suppositories with pumpkin seed oil.
ASSOCIATION OF HYPERTLEPTINEMIA AND GESTATIONAL WEIGHT GAIN
Authors: Ostafiichuk S. O. , Henyk N. I.
Published: July 2021

The aim of the study was to determine the dynamics of leptin plasma concentration in pregnant women, depending on gestational weight gain. This prospective study included 163 pregnant women who visited antenatal clinics in Ivano-Frankivsk, Ukraine during 2016–2018. The recommended GWG was diagnosed in 56 (34.4 %), insufficient in 33 (20.2 %) and excessive in 74 (45.4 %) patients, according to the recommendations of the Institute of Medicine (IOM) in the USA (2009) and the Order of the Ministry of Health of Ukraine № 417 (2011). Anthropometry, gestational weight gain, percentage of body fat mass and concentration of leptin plasma concentration were performed at the first, second and third trimesters of pregnancy. Statistical analyses were carried out using «Statistica 6.0». We demonstrated the association between elevated levels of leptin and gestational weight gain in all pregnant women in spite of prepregnancy body weight. The strongest dynamics of leptin increase was observed in normal weight women with excessive gestational weight gain: progression of hyperleptinemia during pregnancy was more intensive than in overweight. Higher second trimester leptin levels were positive associated with a greater subsequent weight gain and percentage of body fat mass, especially expressed in excessive weight gain women. The development of leptin resistance in these patients may be as a trigger for postpartum weight retention, overweight and obesity.
REINNERVATION AS A METHOD OF TREATMENT OF ONE-SIDED ABDUCTION LARYNX PARALYSIS IN OPERATIONS ON THYROID GLAND
Authors: Palamarchuk V. О. , Тоvkai О. А. , Voitenko V. V.
Published: July 2021

Introduction. The use of selective larynx reinnervation creates the prerequisites for the resumption of synchronous mobility of the vocal folds and is used to correct breathing problems in the case of bilateral laryngeal paralysis, but it can be used to correct unilateral abduction paralysis during an operation on the thyroid gland. Objective: To assess the possibility of performing selective larynxreinnervation during abduction unilateral paralysis in thyroid surgery. Materials and methods: All patients underwent examination of the larynx (fibrolaryngoscopy with data archiving) before and after operation, as well as 4, 6,12,18 months after operation, voice spectral analysis, voice quality assessment (VHI-30), EAT-10 survey (determining the degree of dysphagia). Results. Selective reinnervation was carried out in 2 groups of patients with non-peel-shaped branching of RLN. Group 1 (1 patient) with pre-existing postoperative unilateral laryngeal abduction paralysis, severe dysphonic and moderate aspiration disorders, delayed selective larynx reinnervation was performed (autoplasty of the RLN adduction branch using n. transversus colli fragment). Group 2 (1 patient) performed primary selective larynx reinnervation in connection with resection of the adduction branch of the RLN (tumor invasion into it). An anastomosis of the end-to-end RLN branch of the RLN was performed with three epiperineural sutures. In a patient of group 1, a change in the tone and tension of the free edge of the «paralyzed» vocal fold was recorded 15 months after reinnervation, and the first signs of coordinated movement — after 18 months — fully recovered in almost 2 years. In a patient of group 2, the restoration of the tone of the «paralyzed» vocal fold and the restoration of its mobility were recorded 4 months after larynx reinnervation. In both patients, there was a recovery of the main indicators of the spectral analysis of the voice to normal values, as well as a decrease in the indices (points) of dysphagia on the EAT-10 scale and the index of voice disorders on the VHI-30 scale to normal. Conclusions: Selective larynx reinnervation is applicable not only to eliminate respiratory failure with bilateral laryngeal paralysis, but also to restore voice function, to eliminate the symptoms of aspiration in unilateral laryngeal paralysis. Taking into account the statistical unreliability of the groups of this research and the complexity of this methodology in practical application, it requires further study and a multidisciplinary approach.
GLIMEPIRIDE — ASSISTANT TESTED BY TIME
Authors: Orlyk О. S.
Published: July 2021

The article highlights the current approaches to the treatment and criteria for compensation of diabetes, based on new international recommendations. Much attention is paid to nutrition, lifestyle modification, education and patient self-control, as the basis for successful treatment of diabetes. A review of clinical studies in which were studied the glucose lowering ability of glimepiride, the effect on insulin resistance, the processes of atherogenesis, and the protective effect on the vascular wall were presented.
INFLUENCE OF GASTROINTESTINAL HORMONES ON THE DEVELOPMENT OF OBESITY AND NON-ALCOHOLIC FATTY LIVER DISEASE IN CHILDREN
Authors: Parkhomenko L. K. , Strashok L. A. , Khomenko M. A.
Published: July 2021

Obesity is becoming a global epidemic among children, and the social significance of this problem is determined by the threat of disability of young patients, reducing life expectancy and the development of severe comorbidities. As a result of the increasing number of studies on energy homeostasis, it has been suggested that obesity is a multifactorial and more complex disease than previously thought. In recent years, the attention of researchers is increasingly attracted to the study of intestinal microbiota and its impact on human health, due to the development of new technologies and methods of studying the microbiome. Recent studies have shown that there is a mutual influence of the brain and intestines on each other, and there is increasing evidence that confirms the role of this complex relationship in the regulation of hunger, satiation and energy balance. It is proved that there is a direct impact on these processes of intestinal microbiota, and mediated through its intervention in the synthesis and metabolism of hormones and biologically active compounds of the digestive system. Today it is known that the gastrointestinal tract is one of the human organs where the most hormones are synthesized. At the present stage of development of science, it is known that there are more than 30 gastrointestinal hormones and biologically active substances that regulate the processes of digestion and participate in the regulation of general homeostasis. The most important role in the development of obesity and non-alcoholic fatty liver disease belongs to hormones such as ghrelin, peptide YY and glucagon-like peptide 1. The literature review presents current data that demonstrate the role of gastrointestinal hormones in the formation and development of obesity and non-alcoholic fatty liver disease in children as well as data of own research.
CONTEMPORARY IDEAS ABOUT PATHOPHYSIOLOGICAL MECHANISMS OF IMMUNITY DESTRUCTION IN THE PRECLINICAL STAGE OF TYPE 1 DIABETES
Authors: Popova V. V. , Zak K. P. , Tron’ko N. D.
Published: July 2021

The results of own studies on the role of the immune system in mechanisms for development of type 1 diabetes mellitus (T1DM) in humans that have been performed for 20 years in 612 normoglycemic children of Ukraine with a burden heredity which are positive and negative against pancreatic islet autoantibodies (OAA) are summarized in the article according to the program of the IPDM. There were confirmed data that the high titre of two (especially IA-2A and GADA) and more OAA is a reliable biomarker for diagnosing the presence of preclinical asymptomatic stage of T1DM and predicting its appearance in advance (sometimes for years) in still healthy people. The preclinical stage in OAA-positive children is characterized by moderate neutrophilopenia, monocytosis with a change in their ultrastructure, a decrease in the absolute number of CD3 + T, CD4 + T and CD8 + T lymphocytes and CD56 + cells. In the subpopulation of CD4 + T cells, a disorder of the submicroscopic organization of Holl's bodies is noted. At the same time, there is an increase in the level of proinflammatory cytokines IL-1α, IL-1β, IL-6 and TNFα, as well as chemokines IL-8 and IL-10 and simultaneous decrease of immunoregulatory cytokines IL-4 and IL-10. The obtained data indicate that already in the preclinical stage of T1DM immunity is significantly impaired in the body of normoglycemic children, that is consistent with the recently expressed opinion that the T1DM should be diagnosed not only when most of the beta cells have been destroyed, but in the stage of pre-diabetes, when immune intervention preventing the progression of the disease is still possible.
ACROMEGALY COMBINED WITH GIGANTISM ASSOCIATED WITH THE AIP-GENE MUTATION: A CLINICAL CASE
Authors: Nikolaiev R. , Rostomyan L. , Beckers A. , Tsymbaliuk V. , Khyzhnyak O. , Guk M. , Mykytyuk M. , Karachentsev Iu. , Sanina Y.
Published: July 2021

Pituitary gigantism is an extremely rare disorder: the incidence of pituitary tumors in children is approximately 0.1 in one million, and only about 1 to 10% of the pituitary tumors secrete the GH in childhood. Gigantism should be suspected if the patient's height is 3 standard deviations above the normal average height or 2 standard deviations above the corrected height of parents. When pituitary gigantism is suspected, the clinician should consider the presence of disorders, known to be associated with the GH-secreting pituitary tumors, including the McCune Albright syndrome (MAS), Carney complex (CNC), multiple endocrine neoplasia, types 1 and 4 (MEN 1, MEN 4), Familial isolated pituitary adenoma (FIPA), the paraganglioma, pheochromocytoma and pituitary adenoma association (PAA) due to succinate dehydrogenase defects, and X-linked acrogigantism (X-LAG). The molecular genetics of the AIP-associated FIPA, MAS, CNC, and MEN 1 has been extensively studied and reviewed, especially in children and young adults. The GH-secreting adenomas seem to be more invasive and aggressive in childhood than in adulthood. Data on a rare disease — gigantism combined with phenotypic signs of acromegaly in a young patient are presented. Clinical and laboratory parameters, data of histological and genetic analysis are described. Genetic analysis performed by AIP gene by Sequencing, proved a rare mutation in the locus of exons 1-6 of the AIP gene. The presented clinical case describes a rare fact of the AIP-gene mutation in the p.Cys238Tyr locus, which is associated with the occurrence of a giant pituitary adenoma in childhood. Aggressive growths of the pituitary tumor, its high proliferative and hormonal activity, clinical manifestations of gigantism in combination with severe phenotypic signs of acromegaly have also been noticed. Resistance to the therapy with somatostatin analogs has been revealed in this case. Considering the absence of genetic predisposition to a pituitary adenoma in the patient, this case can be regarded as a sporadic pituitary adenoma variant due to the abnormal AIP-gene expression and the disturbance of regulation during tumorigenesis.
Designing Videos With and for Adults With ADHD for an Online Intervention: Participatory Design Study and Thematic Analysis of Evaluation
Authors: Flobak Eivind , Nordby Emilie Sektnan , Guribye Frode , Kenter Robin , Nordgreen Tine , Lundervold Astri J
Published: July 2021

Background

Adults with attention deficit hyperactivity disorder (ADHD) represent a heterogeneous group with both strengths and difficulties associated with the diagnosis. An online intervention attuned to their needs may improve their everyday functioning. When designing online interventions, it is important to adapt the therapeutic content to the values and needs of the target group.

Objective

This paper describes and evaluates a participatory process used to produce content for an online intervention for adults with ADHD by producing video vignettes clarifying core training principles grounded in the participants' everyday experiences.

Methods

We report on the qualitative data from 2 research phases: the design and evaluation of video vignettes for an online intervention. In the first phase, 12 adults with ADHD, 2 clinicians, and 2 research assistants participated in the production of video vignettes for the online intervention. In the second phase, participants (n=109) gave feedback on the videos as part of a clinical trial of the intervention. A subgroup (n=7) was interviewed in-depth regarding their experiences with the videos. The qualitative data were analyzed using thematic analysis.

Results

In the first phase, the participants with ADHD contributed with experiences from challenging everyday situations. In the process, we navigated between therapeutic principles and the participants' experiential perspectives to create content relevant and consistent with the target group's values and experiences. In the second phase, we identified 3 themes related to the participants' experiences and interpretation of the video vignettes: (1) recognition of ADHD-related challenges, (2) connection with the characters and the situations, and (3) video protagonists as companions and role models for change.

Conclusions

A participatory design process for designing online mental health interventions can be used to probe and balance between the therapeutic principles defined by clinicians and the participants’ experiences with mental health issues in the production of therapeutic content. In our study, the inclusion of video vignettes in an online intervention enabled a contextualized and relevant presentation of everyday experiences and psychosocial factors in the life of an adult with ADHD.

Trial Registration

ClinicalTrials.gov NCT04511169; https://clinicaltrials.gov/ct2/show/NCT04511169
Improving treatment of distal tubular renal acidosis: guidance from ERKNet/ESPN
Authors: Authors No
Published: July 2021

No abstract
World Kidney Day 2021: “Living well with kidney disease”
Authors: Authors No
Published: July 2021

No abstract
LAS FINANZAS DE LOS HOGARES MEXICANOS: ANÁLISIS CON REDES BAYESIANAS
Authors: Dávila Aragón Griselda , Ortiz Arango Francisco , Cabrera Llanos Agustín I.
Published: July 2021

El bienestar de los hogares está ligado en gran parte al desarrollo de los mercados financieros. El estudio de las finanzas de los hogares analiza las formas en que estos utilizan instrumentos financieros para satisfacer sus necesidades y objetivos; este análisis representa un gran desafío debido a la escasa información estadística y la interrelación entre las variables consideradas. En este trabajo, pionero en el uso de las redes bayesianas en este campo, utilizamos de manera conjunta las finanzas tradicionales y las conductuales. Medimos la probabilidad de prevalencia de estabilidad financiera de los hogares en México; obtenemos un resultado base y posteriormente, al generar distintos escenarios, descubrimos que las variables más determinantes son el manejo del crédito y la conformación de los hogares. Estos resultados subrayan la importancia de promover iniciativas de educación financiera en los distintos niveles, modalidades y subsistemas educativos.

 

THE FINANCE OF MEXICAN HOUSEHOLDS: ANALYSIS WITH BAYESIAN NETWORKS

ABSTRACT

In today's economy, the well-being of households is considered to be linked mainly to the development of financial markets. The field of household finance analyzes how households use financial instruments to satisfy their needs and achieve objectives. This analysis represents a significant challenge due to scarce statistical information and the interrelation among the variables involved. We follow two aspects: Traditional and behavioral finance. This paper pioneers the use of Bayesian networks in the field. A model measuring the probability of prevalence of financial stability of households in Mexico is used; a baseline result is obtained and then, while generating different scenarios, we discover that credit management and household composition are the most determining variables. These results underscore the importance of promoting different financial education initiatives at different educational levels, modalities, and subsystems.
Formulation and Antioxidant Test of Baby Instant Porridge with Kepok Banana Flour and Tempe
Authors: Sukardi Sukardi , Wista Selvy Triskiana , Wahyudi Vritta Amroini
Published: July 2021

Commercial instant porridge generally chooses to use rice flour as a carbohydrate source, including instant porridge specifically for babies. The high current consumption of rice is encouraging various food diversification efforts to avoid dependence on one commodity. Kepok banana flour can be used as a substitute for carbohydrates in instant baby porridge, mainly from rice flour and tempe as a source of protein. Banana leaves and teak leaves were chosen as a wrapper for tempe to affect the chemical and organoleptic properties of instant baby porridge. The purpose of this study was to obtain instant baby porridge products which have nutritional value according to the SNI 01-71111.1-2005 standards regarding complementary foods. This study used a completely randomized design (CRD), consist of tempe packaging, namely banana leaves and teak leaves, which were carried out three times using the pairwise difference test (t-test) as a statistical test. Instant baby porridge with tempe treatment packed with banana leaves is an instant baby porridge that is closest to SNI 01-7111.1-2005 concerning complementary feeding with a moisture content value of 18.89%, ash content 2.71%, protein content 6.66%, fat content 16.96%, carbohydrate content 54.77%, 76.70% antioxidant activity, and the highest preference level with a value of 4.87
Inclusiones desiguales en Latinoamérica y Europa: homofobia y racismo bajo el prisma del homonacionalismo
Authors: Dominguez Amoros Marius , Freude Leon
Published: July 2021

El término homonacionalismo ofrece una nueva aproximación a la relación entre racismo y tolerancia con gais y lesbianas en sociedades contemporáneas. Este trabajo presenta un estudio comparativo sobre la extensión y evolución de valores homonacionalistas en Argentina, España, Países Bajos y Uruguay entre 1989-1993 y 2010-2014 siendo uno de los pocos trabajos cuantitativos en los estudios sobre homonacionalismo. Mediante el análisis de las oleadas de la World Value Survey para los distintos países, se operativiza el concepto para evidenciar la irrupción de los valores homonacionalistas en Europa a partir de 2001; así como su extensión a otras regiones propicias para la construcción de un excepcionalismo sexual. Los resultados si bien constatan su fuerte presencia en los discursos contradicen la hegemonía homonacionalista en los valores de las sociedades.
Motivaciones posmaterialistas de las acciones económicas de las personas. Estudio de caso de seis monedas sociales en España
Authors: Ávila Sánchez Manuel , Tezanos Vázquez Sergio
Published: July 2021

Este artículo analiza los factores que motivan la participación en seis monedas sociales en España. En primer lugar se identifican las motivaciones de los usuarios mediante una herramienta de consenso, el método Delphi, en la que participan los representantes de las monedas. En segundo lugar se pondera la importancia de dichas motivaciones mediante una encuesta al conjunto de sus usuarios. Y, finalmente, se evalúan estas motivaciones como satisfactores de necesidades según el esquema de Max-Neef. Los principales hallazgos son la identificación de los aspectos que motivan la participación en las monedas sociales, todos de carácter posmaterialista; que todos ellos influyen en la mayoría de las necesidades vitales de las personas; y que integran una serie de dimensiones ambiental, política, social y filosófica de las acciones económicas de las personas que el sistema económico monetario no considera, y que se intentan recuperar por medio de alternativas económicas como las monedas sociales.
La perspectiva tecnosocial feminista como antídoto para la misoginia online
Authors: Rubio Martín María José , Gordo López Ángel
Published: July 2021

Este artículo revisa las principales aportaciones de la perspectiva tecnosocial feminista frente a la violencia sexual y de género en entornos digitales (a lo que denominamos “misoginia online”). Para ello se realiza una revisión de las contribuciones producidas en el ámbito de las ciencias sociales, referidas a la misoginia onlineoccidental, principalmente las publicadas en lengua inglesa y española,con el fin de ofrecer una panorámica de las posturas actuales y sus estudios más representativos. Además, ponemos especial atención en el modo que la perspectiva tecnosocial feminista y su concepto de “disposición tecnosexual” (affordance tecnosexual) encuentran correspondencia con el análisis crítico de los entornos digitales. Ilustramos esta relación con ejemplos que muestran cómo el diseño de estos entornos puede predisponer a reificar determinadas relaciones de género y poder, entendidascomo parte de un contexto más amplio de discriminación estructural y sistemática contra las mujeres.
El papel del consumo en la economía de plataformas: el vínculo oculto
Authors: Alonso Luis Enrique , Fernández Rodríguez Carlos J.
Published: July 2021

La economía de las plataformas o gig economy, además de suponer una auténtica revolución en los mercados, está generando un impacto muy controvertido sobre las condiciones de empleo en muchos sectores, con la proliferación de nuevos trabajos precarios. Sin embargo, no podemos entender esta metamorfosis del trabajo prestando atención únicamente a la esfera de la producción y las estrategias de gestión de las empresas, sino que debemos fijar nuestra mirada en otros aspectos. Uno de ellos, esencial pero generalmente menos explorado en los análisis sobre esta nueva economía, es el del consumo. No hay gig economy sin la emergencia de formas de consumo y estilos de vida muy concretos, vinculados a la digitalización y el uso extendido de los algoritmos como nueva estrategia de segmentación de mercados. En esta contribución, nuestro objetivo es el de ofrecer una reflexión sobre la importancia que el espacio del consumo tiene en la construcción de este modelo económico de las plataformas, discutiendo sus implicaciones y mostrando su vínculo, muchas veces oculto, con el tipo de empleo que se genera.
Anton Chekhov’s Sakhalin Island: An Ongoing Commentary
Authors: Spachil Olga V.
Published: July 2021

A study of the currently existing translations of Anton Chekhovs Sakhalin Island (From Travel Notes) (Luba and Michael Terpak - 1967, Brian Reeve - 1993) shows that the reason for some errors in translated texts is not always due to the negligence of translators, which is so clearly noticeable in the first translation, but rather in the incomprehensibi- lity for foreigners of some realia in the original text. Reference to two available Сommentaries on Sakhalin Island, by M.L. Semanova (1985) and M.S. Vysokov (2010), as well as to the works of other Chekhov scholars, did not give the sought-after explanations of certain vague excerpts from the book. Those obscure excerpts are also poorly understood by the Russian readership. In particular, we are talking about Chekhovs mention of the use of a naval rope in the surgical department (Chapter VII) and the perception of the status of a class feldscher/paramedic (Chapter XII). The author of the article offers her own commentary on difficult-to-understand passages and thus fills the gap that has arisen. Conclusions are drawn about the need to continue to provide Chekhovs Sakhalin Island with commentaries and notes. Such commentary should serve two purposes. Its linguistic and cultural character should help to clarify the realias not only for representatives of a foreign linguistic culture - in order to prevent gross errors in translations, but also for the present-day Russian reader, separated from the time when A.P. Chekhovs book was written by almost one hundred and thirty years.