bluuebunny/crossref_metadata_2025 huggingface dataset:
Regional Forecasting of Wind Speeds during Typhoon Landfall in Taiwan: A Case Study of Westward-Moving Typhoons
Authors: Wei Chih-Chiang , Peng Po-Chun , Tsai Cheng-Han , Huang Chien-Lin
Published: April 2018

Taiwan is located on a route where typhoons often strike. Each year, the strong winds accompanying typhoons are a substantial threat and cause significant damage. However, because the terrains of high mountains in Taiwan vary greatly, when a typhoon passes the Central Mountain Range (CMR), the wind speed of typhoons becomes difficult to predict. This research had two primary objectives: (1) to develop data-driven techniques and a powerful artificial neural network (ANN) model to predict the highly complex nonlinear wind systems in western Taiwan; and, (2) to investigate the accuracy of wind speed predictions at various locations and for various durations in western Taiwan when the track of westward typhoons is affected by the complex geographical shelters and disturbances of the CMR. This study developed a typhoon wind speed prediction model that evaluated various typhoon tracks (covering Type 2, Type 3, and Type 4 tracks, as defined by the Central Weather Bureau), and evaluated the prediction accuracy at Hsinchu, Wuqi, and Kaohsiung Stations in western Taiwan. Back propagation neural networks (BPNNs) were employed to establish wind speed prediction models, and a linear regression model was adopted as the benchmark to evaluate the strengths and weaknesses of the BPNNs. The results were as follows: (1) The BPNNs generally had favorable performance in predicting wind speeds and their performances were superior to linear regressions; (2) when absolute errors were adopted to evaluate the prediction performances, the predictions at Hsinchu Station were the most accurate, whereas those at Wuqi Station were the least accurate; however, when relative errors were adopted, the predictions at Hsinchu Station were again the most accurate, whereas those at Kaohsiung were the least accurate; and, (3) regarding the relative error rates for the maximum wind speed of Types 2, 3, and 4 typhoons, Wuqi, Kaohsiung, and Wuqi had the most accurate performance, respectively; as for maximum wind time error (ETM) for Types 2, 3, and 4 typhoons, Kaohsiung, Wuqi, and Wuqi correspondingly performed the most favorably.
Raman Spectroscopic and Microscopic Analysis for Monitoring Renal Osteodystrophy Signatures
Authors: Ciubuc John , Manciu Marian , Maran Avudaiappan , Yaszemski Michael , Sundin Emma , Bennet Kevin , Manciu Felicia
Published: April 2018

Defining the pathogenesis of renal osteodystrophy (ROD) and its treatment efficacy are difficult, since many factors potentially affect bone quality. In this study, confocal Raman microscopy and parallel statistical analysis were used to identify differences in bone composition between healthy and ROD bone tissues through direct visualization of three main compositional parametric ratios, namely, calcium content, mineral-to-matrix, and carbonate-to-matrix. Besides the substantially lower values found in ROD specimens for these representative ratios, an obvious accumulation of phenylalanine is Raman spectroscopically observed for the first time in ROD samples and reported here. Thus, elevated phenylalanine could also be considered as an indicator of the disease. Since the image results are based on tens of thousands of spectra per sample, not only are the average ratios statistically significantly different for normal and ROD bone, but the method is clearly powerful in distinguishing between the two types of samples. Furthermore, the statistical outcomes demonstrate that only a relatively small number of spectra need to be recorded in order to classify the samples. This work thus opens the possibility of future development of in vivo Raman sensors for assessment of bone structure, remodeling, and mineralization, where different biomarkers are simultaneously detected with unprecedented accuracy.
Performance of Blue-Green Roofs in Cold Climates: A Scoping Review
Authors: Andenæs Erlend , Kvande Tore , Muthanna Tone , Lohne Jardar
Published: April 2018

Green and blue-green roofs are emerging as an increasingly popular feature of rooftops, particularly in urban areas. Particular problematic conditions render their usage complex in the Nordic countries. In order to ensure that green roofs are built durable and with the service life expected of them, it is important to know all the relevant factors surrounding their construction and operation. A scoping study was conducted in order to gain an overview on green roof research and available scientific literature. One hundred articles of particular interest for Nordic climates were retrieved and their findings summarized. It is found that the vast majority of green roof research has been conducted on a theoretical basis, or with practical measurements on green roof test beds or isolated components. There is scarcely any literature on the operation of full-scale, building-implemented green roofs, and no articles were found on the building technical performance of aged green roofs. These knowledge gaps indicate a major risk factor in green roof operation, as their performance and integrity over time has not been documented. This despite the fact that green roofs have been implemented and in operation worldwide for decades.
Thermal Comfort Analyses of Secondary School Students in the Tropics
Authors: Hamzah Baharuddin , Gou Zhonghua , Mulyadi Rosady , Amin Samsuddin
Published: April 2018

This study aims to analyze the thermal comfort level of students in secondary schools in the tropical city of Makassar. The analysis is carried out based on data surveyed from eight selected high schools. The study involved 1594 students in 48 classrooms. The recorded data includes personal data and measured environmental parameters. At the same time, students were asked to fill out questionnaires related to their thermal comfort levels. The surveyed classrooms showed high air temperatures. The air temperatures ranged from 28.2 °C in the morning to 33.6 °C in the midday. The radiant temperatures were similar to the air temperature, which indicated that the airflow speed was low. The only parameter that could meet the Indonesian national standard was relative humidity. However, many students still feel comfortable (−1 to +1) based on TSV (thermal sensation vote) and TCV (thermal comfort vote). Even though about 80% of respondents accepted this hot temperature, most of them preferred to have a decrease in the air temperature. Regarding the PMV (predicted mean vote), only about 23% respondents were predicted to feel slightly warm (+1). The regression analyses show that the neutral temperatures were 29.0 °C and 28.5 °C for TSV and TCV, respectively.
EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers
Authors: Wilson Joanna , Manet Evelyne , Gruffat Henri , Busson Pierre , Blondel Marc , Fahraeus Robin
Published: April 2018

The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer cells from normal cells and thereby offers opportunities for targeted therapeutic intervention. EBNA1 is essential for viral genome maintenance and also for controlling viral gene expression and without EBNA1, the virus cannot persist. EBNA1 itself has been linked to cell transformation but the underlying mechanism of its oncogenic activity has been unclear. However, recent data are starting to shed light on its growth-promoting pathways, suggesting that targeting EBNA1 can have a direct growth suppressing effect. In order to carry out its tasks, EBNA1 interacts with cellular factors and these interactions are potential therapeutic targets, where the aim would be to cripple the virus and thereby rid the tumour cells of any oncogenic activity related to the virus. Another strategy to target EBNA1 is to interfere with its expression. Controlling the rate of EBNA1 synthesis is critical for the virus to maintain a sufficient level to support viral functions, while at the same time, restricting expression is equally important to prevent the immune system from detecting and destroying EBNA1-positive cells. To achieve this balance EBNA1 has evolved a unique repeat sequence of glycines and alanines that controls its own rate of mRNA translation. As the underlying molecular mechanisms for how this repeat suppresses its own rate of synthesis in cis are starting to be better understood, new therapeutic strategies are emerging that aim to modulate the translation of the EBNA1 mRNA. If translation is induced, it could increase the amount of EBNA1-derived antigenic peptides that are presented to the major histocompatibility (MHC) class I pathway and thus, make EBV-carrying cancers better targets for the immune system. If translation is further suppressed, this would provide another means to cripple the virus.
New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An Update
Authors: Montaño Adrián , Forero-Castro Maribel , Marchena-Mendoza Darnel , Benito Rocío , Hernández-Rivas Jesús María
Published: April 2018

The identification and study of genetic alterations involved in various signaling pathways associated with the pathogenesis of acute lymphoblastic leukemia (ALL) and the application of recent next-generation sequencing (NGS) in the identification of these lesions not only broaden our understanding of the involvement of various genetic alterations in the pathogenesis of the disease but also identify new therapeutic targets for future clinical trials. The present review describes the main deletions, amplifications, sequence mutations, epigenetic lesions, and new structural DNA rearrangements detected by NGS in B-ALL and T-ALL and their clinical importance for therapeutic procedures. We reviewed the molecular basis of pathways including transcriptional regulation, lymphoid differentiation and development, TP53 and the cell cycle, RAS signaling, JAK/STAT, NOTCH, PI3K/AKT/mTOR, Wnt/β-catenin signaling, chromatin structure modifiers, and epigenetic regulators. The implementation of NGS strategies has enabled important mutated genes in each pathway, their associations with the genetic subtypes of ALL, and their outcomes, which will be described further. We also discuss classic and new cryptic DNA rearrangements in ALL identified by mRNA-seq strategies. Novel cooperative abnormalities in ALL could be key prognostic and/or predictive biomarkers for selecting the best frontline treatment and for developing therapies after the first relapse or refractory disease.
Construction and Characterization of a Humanized Anti-Epstein-Barr Virus gp350 Antibody with Neutralizing Activity in Cell Culture
Authors: Tanner Jerome , Hu Jing , Alfieri Caroline
Published: April 2018

Acute Epstein-Barr virus (EBV) infection in immunosuppressed transplant patients can give rise to a malignant B-cell proliferation known as post-transplant lymphoproliferative disease (PTLD). The EBV major virion surface glycoprotein (gp)350 is a principal target of naturally occurring neutralizing antibodies and is viewed as the best target to prevent acute infection and PTLD in at-risk transplant recipients. We have constructed a humanized (hu) version of the murine anti-gp350 neutralizing monoclonal antibody 72a1. The hu72a1 IgG1 antibody displayed no significant anti-mouse activity, recognized both gp350 and its splice variant gp220 as well as a gp350 peptide that was shown to constitute the principal EBV gp350 neutralizing epitope when tested in immunoassays. Hu72a1 antibody blocked in vitro EBV infection of B cells at a level which equaled that of a mouse-human chimeric 72a1 antibody construct. This work provides a further structural and immunological understanding of the 72a1 antibody interaction with EBV gp350, and constitutes a launch point for future anti-EBV therapeutic antibodies designed to block EBV infection and prevent PTLD while eliminating the deleterious antigenic murine features of the original 72a1 antibody.
Proton Beam Therapy Alone for Intermediate- or High-Risk Prostate Cancer: An Institutional Prospective Cohort Study
Authors: Arimura Takeshi , Yoshiura Takashi , Matsukawa Kyoko , Kondo Naoaki , Kitano Ikumi , Ogino Takashi
Published: April 2018

The role of proton beam therapy (PBT) as monotherapy for localized prostate cancer (PCa) remains unclear. The purpose of this study was to evaluate the efficacy and adverse events of PBT alone for these patients. Between January 2011 and July 2014, 218 patients with intermediate- and high-risk PCa who declined androgen deprivation therapy (ADT) were enrolled to the study and were treated with PBT following one of the following protocols: 74 Gray (GyE) with 37 fractions (fr) (74 GyE/37 fr), 78 GyE/39 fr, and 70 GyE/28 fr. The 5-year progression-free survival rate in the intermediate- and high-risk groups was 97% and 83%, respectively (p = 0.002). The rate of grade 2 or higher late gastrointestinal toxicity was 3.9%, and a significant increased incidence was noted in those who received the 78 GyE/39 fr protocol (p < 0.05). Grade 2 or higher acute and late genitourinary toxicities were observed in 23.5% and 3.4% of patients, respectively. Our results indicated that PBT monotherapy can be a beneficial treatment for localized PCa. Furthermore, it can preserve the quality of life of these patients. We believe that this study provides crucial hypotheses for further study and for establishing new treatment strategies.
Flotillins Regulate Focal Adhesions by Interacting with α-Actinin and by Influencing the Activation of Focal Adhesion Kinase
Authors: Banning Antje , Babuke Tanja , Kurrle Nina , Meister Melanie , Ruonala Mika O. , Tikkanen Ritva
Published: April 2018

Cell–matrix adhesion and cell migration are physiologically important processes that also play a major role in cancer spreading. In cultured cells, matrix adhesion depends on integrin-containing contacts such as focal adhesions. Flotillin-1 and flotillin-2 are frequently overexpressed in cancers and are associated with poor survival. Our previous studies have revealed a role for flotillin-2 in cell–matrix adhesion and in the regulation of the actin cytoskeleton. We here show that flotillins are important for cell migration in a wound healing assay and influence the morphology and dynamics of focal adhesions. Furthermore, anchorage-independent growth in soft agar is enhanced by flotillins. In the absence of flotillins, especially flotillin-2, phosphorylation of focal adhesion kinase and extracellularly regulated kinase is diminished. Flotillins interact with α-actinin, a major regulator of focal adhesion dynamics. These findings are important for understanding the molecular mechanisms of how flotillin overexpression in cancers may affect cell migration and, especially, enhance metastasis formation.
Ponseti Technique for the Management of Congenital Talipes Equinovarus in a Rural Set-Up in India: Experience of 356 Patients
Authors: Malhotra Rohit , Mohapatra Ashutosh , Arora Geetika , Choudhury Priyam , Joshi Hitesh , Patel Pranav
Published: April 2018

Congenital talipes equinovarus (CTEV), also known as clubfoot, is a complex congenital deformity of the foot that, left untreated, can limit a person’s mobility by making it difficult and painful to walk. Worldwide, 80% of children born with clubfoot are in low- and middle-income countries. The management of clubfoot has a long history. Non-operative management did not become popular, as an increasing number of orthopaedists started leaning towards surgical treatment. The late Dr. Ignacio Ponseti developed a method of clubfoot correction that successfully realigns clubfoot in infants without extensive and major surgery. The aim of the study was to assess the functional outcome of CTEV management by the Ponseti technique, to study the severity of CTEV deformity using the Pirani score, and to evaluate the cost-effectiveness of the technique. A total of 356 cases with 402 feet with CTEV were treated by the Ponseti method. The average age of the children and the number of casts applied before full correction were 4.03 months and 6.91, respectively. There was a good functional outcome in 95.45% of cases (score > 30) at the last follow up. The management of CTEV by the Ponseti technique provides a good functional and cosmetic outcome. In a developing country like India, this technique is a safe, easy, economical method of clubfoot management.
Comparison between Simulation and Analytical Methods in Reliability Data Analysis: A Case Study on Face Drilling Rigs
Authors: Hoseinie Seyed , Al-Chalabi Hussan , Ghodrati Behzad
Published: April 2018

Collecting the failure data and reliability analysis in an underground mining operation is challenging due to the harsh environment and high level of production pressure. Therefore, achieving an accurate, fast, and applicable analysis in a fleet of underground equipment is usually difficult and time consuming. This paper aims to discuss the main reliability analysis challenges in mining machinery by comparing three main approaches: two analytical methods (white-box and black-box modeling), and a simulation approach. For this purpose, the maintenance data from a fleet of face drilling rigs in a Swedish underground metal mine were extracted by the MAXIMO system over a period of two years and were applied for analysis. The investigations reveal that the performance of these approaches in ranking and the reliability of the studies of the machines is different. However, all mentioned methods provide similar outputs but, in general, the simulation estimates the reliability of the studied machines at a higher level. The simulation and white-box method sometimes provide exactly the same results, which are caused by their similar structure of analysis. On average, 9% of the data are missed in the white-box analysis due to a lack of sufficient data in some of the subsystems of the studies’ rigs.
An Efficient Computational Technique for Fractal Vehicular Traffic Flow
Authors: Kumar Devendra , Tchier Fairouz , Singh Jagdev , Baleanu Dumitru
Published: April 2018

In this work, we examine a fractal vehicular traffic flow problem. The partial differential equations describing a fractal vehicular traffic flow are solved with the aid of the local fractional homotopy perturbation Sumudu transform scheme and the local fractional reduced differential transform method. Some illustrative examples are taken to describe the success of the suggested techniques. The results derived with the aid of the suggested schemes reveal that the present schemes are very efficient for obtaining the non-differentiable solution to fractal vehicular traffic flow problem.
On a Robust MaxEnt Process Regression Model with Sample-Selection
Authors: Kim Hea-Jung , Bae Mihyang , Jin Daehwa
Published: April 2018

In a regression analysis, a sample-selection bias arises when a dependent variable is partially observed as a result of the sample selection. This study introduces a Maximum Entropy (MaxEnt) process regression model that assumes a MaxEnt prior distribution for its nonparametric regression function and finds that the MaxEnt process regression model includes the well-known Gaussian process regression (GPR) model as a special case. Then, this special MaxEnt process regression model, i.e., the GPR model, is generalized to obtain a robust sample-selection Gaussian process regression (RSGPR) model that deals with non-normal data in the sample selection. Various properties of the RSGPR model are established, including the stochastic representation, distributional hierarchy, and magnitude of the sample-selection bias. These properties are used in the paper to develop a hierarchical Bayesian methodology to estimate the model. This involves a simple and computationally feasible Markov chain Monte Carlo algorithm that avoids analytical or numerical derivatives of the log-likelihood function of the model. The performance of the RSGPR model in terms of the sample-selection bias correction, robustness to non-normality, and prediction, is demonstrated through results in simulations that attest to its good finite-sample performance.
Application of a Continuous Particle Swarm Optimization (CPSO) for the Optimal Coordination of Overcurrent Relays Considering a Penalty Method
Authors: Wadood Abdul , Kim Chang-Hwan , Khurshiad Tahir , Farkoush Saeid , Rhee Sang-Bong
Published: April 2018

In an electrical power system, the coordination of the overcurrent relays plays an important role in protecting the electrical system by providing primary as well as backup protection. To reduce power outages, the coordination between these relays should be kept at the optimum value to minimize the total operating time and ensure that the least damage occurs under fault conditions. It is also imperative to ensure that the relay setting does not create an unintentional operation and consecutive sympathy trips. In a power system protection coordination problem, the objective function to be optimized is the sum of the total operating time of all main relays. In this paper, the coordination of overcurrent relays in a ring fed distribution system is formulated as an optimization problem. Coordination is performed using proposed continuous particle swarm optimization. In order to enhance and improve the quality of this solution a local search algorithm (LSA) is implanted into the original particle swarm algorithm (PSO) and, in addition to the constraints, these are amalgamated into the fitness function via the penalty method. The results achieved from the continuous particle swarm optimization algorithm (CPSO) are compared with other evolutionary optimization algorithms (EA) and this comparison showed that the proposed scheme is competent in dealing with the relevant problems. From further analyzing the obtained results, it was found that the continuous particle swarm approach provides the most globally optimum solution.
On the Effects of Variation of Thermal Conductivity in Buildings in the Italian Construction Sector
Authors: Berardi Umberto , Tronchin Lamberto , Manfren Massimiliano , Nastasi Benedetto
Published: April 2018

Stationary and dynamic heat and mass transfer analyses of building components are an essential part of energy efficient design of new and retrofitted buildings. Generally, a single constant thermal conductivity value is assumed for each material layer in construction components. However, the variability of thermal conductivity may depend on many factors; temperature and moisture content are among the most relevant ones. A linear temperature dependence of thermal conductivity has been found experimentally for materials made of inorganic fibers such as rockwool or fiberglass, showing lower thermal conductivities at lower temperatures. On the contrary, a nonlinear temperature dependence has been found for foamed insulation materials like polyisocyanurate, with a significant deviation from linear behavior. For this reason, thermal conductivity assumptions used in thermal calculations of construction components and in whole-building performance simulations have to be critically questioned. This study aims to evaluate how temperature affects thermal conductivity of materials in building components such as exterior walls and flat roofs in different climate conditions. Therefore, experimental conductivities measured for four common insulation materials have been used as a basis to simulate the behavior of typical construction components in three different Italian climate conditions, corresponding to the cities of Turin, Rome, and Palermo.
Water Transport and Removal in PEMFC Gas Flow Channel with Various Water Droplet Locations and Channel Surface Wettability
Authors: Qin Yanzhou , Wang Xuefeng , Chen Rouxian , Shangguan Xiang
Published: April 2018

Water transport and removal in the proton exchange membrane fuel cell (PEMFC) is critically important to fuel cell performance, stability, and durability. Water emerging locations on the membrane-electrode assembly (MEA) surface and the channel surface wettability significantly influence the water transport and removal in PEMFC. In most simulations of water transport and removal in the PEMFC flow channel, liquid water is usually introduced at the center of the MEA surface, which is fortuitous, since water droplet can emerge randomly on the MEA surface in PEMFC. In addition, the commonly used no-slip wall boundary condition greatly confines the water sliding features on hydrophobic MEA/channel surfaces, degrading the simulation accuracy. In this study, water droplet is introduced with various locations along the channel width direction on the MEA surface, and water transport and removal is investigated numerically using an improved model incorporating the sliding flow property by using the shear wall boundary condition. It is found that the water droplet can be driven to the channel sidewall by aerodynamics when the initial water location deviates from the MEA center to a certain amount, forming the water corner flow in the flow channel. The channel surface wettability on the water transport is also studied and is shown to have a significant impact on the water corner flow in the flow channel.
Phytohormones and Effects on Growth and Metabolites of Microalgae: A Review
Authors: Han Xingfeng , Zeng Huiru , Bartocci Pietro , Fantozzi Francesco , Yan Yunjun
Published: April 2018

Microalgae cultivation is booming in agriculture, aquaculture, and bioenergy sectors. A wide range of bioactive compounds with attractive properties can be produced with microalgae, including pigments, vitamins, proteins, carbohydrates, and lipids. The biofuel yields from microalgae can exceed the yields obtained with energy crops by 10–100 times. Therefore, such cultivation is promising for the regulation of the biosynthesis of microalagae with phytohormones, which can enhance the production of high-valued bioproducts. This review reports the effect of auxins, abscisic acid, cytokinins, gibberellins, and ethylene on microalgal growth and metabolites, as well as the crosstalk of different phytohormones. The use of phytohormones is also promising because it can also reduce the inputs necessary to grow the selected microalgae and maximize the yields.
Impact of Saccharomyces cerevisiae Strains on Health-Promoting Compounds in Wine
Authors: Guerrini Simona , Mangani Silvia , Romboli Yuri , Luti Simone , Pazzagli Luigia , Granchi Lisa
Published: April 2018

Moderate wine consumption is associated with human health benefits (reduction of cardiovascular risk and neurodegenerative diseases, decrease of onset of certain cancers) attributed to a series of bioactive compounds, mainly polyphenols, with antioxidant power capable of counteracting the negative action of free radicals. Polyphenols are naturally present in the grapes, but an additional amount originates during winemaking. The aim of this work was to assess the ability of four commercial and two indigenous Saccharomyces cerevisiae strains to produce bioactive compounds (tyrosol, hydroxytyrosol, tryptophol, melatonin and glutathione) during alcoholic fermentation. In order to exclude the fraction of antioxidant compounds naturally occurring in grapes, the strains were inoculated in a synthetic must. At the end of fermentation the bioactive compounds were analysed by High-Performance Liquid Chromatography, while antioxidant activity was measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Moreover, freeze-dried samples, originating from the experimental wines, were used to perform ex-vivo assays on cultured cells (RAW 264.7 murine macrophages) with the aim to evaluate their antioxidant and anti-inflammatory activities. The results indicated that the production of the considered bioactive compounds is a strain-specific property; therefore, the different yeast strains utilized during fermentation have different capabilities to modify the antioxidant and anti-inflammatory properties of the wine.
Using Foucault: Genealogy, Governmentality and the Problem of Chronic Illness
Authors: Reich Ann , Turnbull Margo
Published: April 2018

This article explores the unique contribution that Foucault’s work on genealogy and governmentality can make to the analysis of contemporary programs of government. The article uses an Australian study of the ‘problem’ of chronic illness to argue that this perspective offers valuable insights into how ‘problems’ such as chronic illness have become linked to advanced liberal discourses and practices of self-governing and self-responsibility. These insights are particularly valuable in fields such as primary health care that have a noted shortage of critical and reflective studies that explore the links between people and changing ideas of health and disease. This article details how taking up an analytics of governmentality and political genealogy informed by Foucault, facilitated the tracing of the dominant discourses and practices, and the connections to the day-to -day lives of the clients with chronic diseases. Importantly, this approach opened up a more critical consideration of the ways in which dispersed approaches to governing through programs, such as integrated care, shape and influence the lives of individuals. These dispersed ways of governing are not linear but rather unfold through ongoing relays, connections and the (re)production of discourses.
Estimating Regional Scale Hydroclimatic Risk Conditions from the Soil Moisture Active-Passive (SMAP) Satellite
Authors: Champagne Catherine , Zhang Yinsuo , Cherneski Patrick , Hadwen Trevor
Published: April 2018

Satellite soil moisture is a critical variable for identifying susceptibility to hydroclimatic risks such as drought, dryness, and excess moisture. Satellite soil moisture data from the Soil Moisture Active/Passive (SMAP) mission was used to evaluate the sensitivity to hydroclimatic risk events in Canada. The SMAP soil moisture data sets in general capture relative moisture trends with the best estimates from the passive-only derived soil moisture and little difference between the data at different spatial resolutions. In general, SMAP data sets overestimated the magnitude of moisture at the wet extremes of wetting events. A soil moisture difference from average (SMDA) was calculated from SMAP and historical Soil Moisture and Ocean Salinity (SMOS) data showed a relatively good delineation of hydroclimatic risk events, although caution must be taken due to the large variability in the data within risk categories. Satellite soil moisture data sets are more sensitive to short term water shortages than longer term water deficits. This was not improved by adding “memory” to satellite soil moisture indices to improve the sensitivity of the data to drought, and there is a large variability in satellite soil moisture values with the same drought severity rating.
Basin Resonance and Seismic Hazard in Jakarta, Indonesia
Authors: Cipta Athanasius , Cummins Phil , Irsyam Masyhur , Hidayati Sri
Published: April 2018

We use earthquake ground motion modelling via Ground Motion Prediction Equations (GMPEs) and numerical simulation of seismic waves to consider the effects of site amplification and basin resonance in Jakarta, the capital city of Indonesia. While spectral accelerations at short periods are sensitive to near-surface conditions (i.e., V S 30 , average shear-wave velocity at topmost 30 m of soil), our results suggest that, for basins as deep as Jakarta’s, available GMPEs cannot be relied on to accurately estimate the effect of basin depth on ground motions at long periods (>3 s). Amplitudes at such long periods are influenced by trapping of seismic waves in the basin, resulting in longer duration of strong ground motion, and interference between incoming and reflected waves as well as focusing at basin edges may amplify seismic waves. In order to simulate such phenomena in detail, a basin model derived from a previous study is used as a computational domain for deterministic earthquake scenario modeling in a 2-dimensional cross-section. A M w 9.0 megathrust, a M w 6.5 crustal thrust and a M w 7.0 intraslab earthquake are chosen as scenario events that pose credible threats to Jakarta, and the interactions with the basin of seismic waves generated by these events were simulated. The highest long-period PGVs amplifications are recorded at sites near the middle of the basin and near its southern edge, with maximum amplifications of PGV in the horizontal component of 726% for the crustal, 1500% for the megathrust and 1125% for the deep intraslab earthquake scenario, respectively. We find that the levels of response spectral acceleration fall below those of the 2012 Indonesian building Codes’s design response spectra for short periods (<1 s), but closely approach or may even exceed these levels for longer periods.
Preventing Groundwater Pollution Using Vulnerability and Risk Mapping: The Case of the Florina Basin, NW Greece
Authors: Voudouris Konstantinos , Mandrali Paschalia , Kazakis Nerantzis
Published: April 2018

The alluvial aquifer system of the Florina basin (320 km2) in North Greece is a representative area where irrigated agriculture is applied. Groundwater is the main source of water. The highest and mean nitrate concentrations in groundwater are 67.9 mg/L and 25 mg/L, respectively. High values could be associated with the use of nitrogen fertilizers from agricultural activities. This study deals with the evaluation of the groundwater quality. For this reason, hydrochemical analyses from 29 groundwater samples and water level measurements were performed for the wet and dry periods of 2016. The suitability of groundwater quality for irrigation purposes is examined by using different indices (Chlorinity Index, SAR, Sodium Percentage, Potential Salinity and Kelly’s index). In addition, the DRASTIC method was modified by using statistical methods, land use map and nitrate concentrations and applied in order to assess the groundwater vulnerability to external pollution. Notably, there was no correlation between the standard DRASTIC method and nitrate concentrations. However, the modified version and the obtained risk map showed high correlation with nitrate concentrations (ρ = 0.55) and the Groundwater Quality; hence, it is suggested as the base for a protection plan of the alluvial aquifer.
A Physical Study of the Effect of Groundwater Salinity on the Compressibility of the Semarang-DemakAquitard, Java Island
Authors: Sarah Dwi , Hutasoit Lambok , Delinom Robert , Sadisun Imam , Wirabuana Taufiq
Published: April 2018

Semarang-Demak and other cities along the coast of North Java are vulnerable to land subsidence. The presence of saline groundwater in the coastal region is thought to affect the high subsidence rate, in this case the compressibility of the aquitard layer. We aimed to analyze the effects of groundwater salinity on the compression characteristics of the Semarang-Demak clay using physical analysis. Methods included the determination of groundwater salinity, clay mineralogy and fabrics, and consolidation tests under various salinity conditions. The Semarang-Demak clay is dominated by smectite of high activity, and saline clay exists at the depth of 10 to 35 m. Consolidation tests revealed that the increase insalinity increases the average consolidation rate and hydraulic conductivity up to 42% and 37.5%, respectively. Clay fabric analysis showed that the groundwater salinity modified the interconnectivity of pores by changing the fabric into parallel alignments, facilitating faster porewater dissipation, hence the clay is more readily compressed. These findings are useful for explaining the mechanism of the fast-subsiding coastal plains of North Java.
A Statewide Model for Assisting Nursing Home Residents to Transition Successfully to the Community
Authors: Buttke Darci , Cooke Valerie , Abrahamson Kathleen , Shippee Tetyana , Davila Heather , Kane Rosalie , Arling Greg
Published: April 2018

Minnesota’s Return to Community Initiative (RTCI) is a novel, statewide initiative to assist private paying nursing home residents to return to the community and to remain in that setting without converting to Medicaid. The objective of this manuscript is to describe in detail RTCI’s development and design, its key operational components, and characteristics of its clients and their care outcomes. Data on client characteristics and outcomes come from the Minimum Data Set, staff assessments of clients and caregivers, and Medicaid eligibility files. Most clients transitioned by the RTCI had entered the nursing facility from a hospital. Clients overwhelmingly wanted to return to the community and fit a health and functional profile making them good candidates for community discharge. Most clients went to a private residence, living alone or with a spouse; yet, adult children were the most frequent caregivers. At one year of follow-up 76% of individuals were alive and living in the community and only a small percentage (8.2%) had converted to Medicaid. The RTCI holds promise as a successful model for states to adopt in assisting individuals who are at risk to become long stay nursing home residents instead to return to the community.
Turning the Co-Production Corner: Methodological Reflections from an Action Research Project to Promote LGBT Inclusion in Care Homes for Older People
Authors: Willis Paul , Almack Kathryn , Hafford-Letchfield Trish , Simpson Paul , Billings Barbara , Mall Naresh
Published: April 2018

Background: Older lesbian, gay, bisexual and trans (LGBT) residents are often invisible in long-term care settings. This article presents findings from a community-based action research project, which attempted to address this invisibility through co-produced research with LGBT community members. Particular Question: What conditions enable co-produced research to emerge in long-term residential care settings for older people? Aims of Project: To analyse outcomes and challenges of action-oriented, co-produced research in the given context. In particular, we explore how co-production as a collaborative approach to action-orientated research can emerge during the research/fieldwork process; and reflect critically on the ethics and effectiveness of this approach in advancing inclusion in context. Methods: The project was implemented across six residential care homes in England. Reflections are based on qualitative evaluation data gathered pre- and post-project, which includes 37 interviews with care home staff, managers and community advisors (two of whom are co-authors). Results and Conclusions: We discuss how the co-production turn emerged during research and evaluate how the politics of this approach helped advance inclusion—itself crucial to well-being. We argue for the value of co-produced research in instigating organizational change in older people’s care environments and of non-didactic storytelling in LGBT awareness-raising amongst staff.
Examining Youth Dual and Polytobacco Use with E-Cigarettes
Authors: Lee Youn , Pepper Jessica , MacMonegle Anna , Nonnemaker James , Duke Jennifer , Porter Lauren
Published: April 2018

E-cigarettes and other non-cigarette tobacco products are increasingly popular among youth. Little is known to inform public health efforts to reduce youth use. We examined psychosocial correlates of single and multiple tobacco product use among youth e-cigarette users. Data were from the 2014 Florida Youth Tobacco Survey (N = 69,923), a representative sample of Florida middle and high school students. Associations between combinations of e-cigarette, cigarette and other tobacco product (OTP) use and psychosocial variables were examined using multinomial logistic regression with an analytic sample of N = 2756. Most e-cigarette-using youth used at least one other product (81%). Perceiving cigarettes as easy to quit was significantly associated with greater likelihood of combined e-cigarette/OTP use (relative risk ratio (RRR) = 2.51, p < 0.001) and combined e-cigarette/cigarette/OTP use (RRR = 3.20, p < 0.0001). Thinking you will be smoking cigarettes in 5 years was associated with product combinations that include cigarettes. Tobacco company marketing receptivity was associated with multiple product user types. Given that specific psychosocial factors put youth at risk for concurrent use of e-cigarettes with tobacco products, public health efforts should address polytobacco use specifically, instead of individual product use. Youth perceptions about the ease of quitting cigarettes, intentions to continue smoking cigarettes and receptivity to tobacco company marketing are promising areas for messaging aimed at reducing e-cigarette polytobacco product use.
Comment on Cerland, L. et al. Incidence and Consequences of Near-Drowning-Related Pneumonia—A Descriptive Series from Martinique, French West Indies. Int. J. Environ. Res. Public Health 2017, 14, 1402
Authors: Queiroga Ana , Webber Jonathon , Schmidt Andrew , Sempsrott Justin , Barcala-Furelos Roberto , Tipton Michael , Szpilman David
Published: April 2018

We read with great interest the recent paper by Cerland et al. on the frequency, nature, and consequences of post-drowning pneumonia[...]
A Socio-Technical Exploration for Reducing & Mitigating the Risk of Retained Foreign Objects
Authors: Corrigan Siobhán , Kay Alison , O’Byrne Katie , Slattery Dubhfeasa , Sheehan Sharon , McDonald Nick , Smyth David , Mealy Ken , Cromie Sam
Published: April 2018

A Retained Foreign Object (RFO) is a fairly infrequent but serious adverse event. An accurate rate of RFOs is difficult to establish due to underreporting but it has been estimated that incidences range between 1/1000 and 1/19,000 procedures. The cost of a RFO incident may be substantial and three-fold: (i) the cost to the patient of physical and/or psychological harm; (ii) the reputational cost to an institution and/or healthcare provider; and (iii) the financial cost to the taxpayer in the event of a legal claim. This Health Research Board-funded project aims to analyse and understand the problem of RFOs in surgical and maternity settings in Ireland and develop hospital-specific foreign object management processes and implementation roadmaps. This project will deploy an integrated evidence-based assessment methodology for social-technical modelling (Supply, Context, Organising, Process & Effects/ SCOPE Analysis Cube) and bow tie methodologies that focuses on managing the risks in effectively implementing and sustaining change. It comprises a multi-phase research approach that involves active and ongoing collaboration with clinical and other healthcare staff through each phase of the research. The specific objective of this paper is to present the methodological approach and outline the potential to produce generalisable results which could be applied to other health-related issues.
Evaluating the Open Source Data Containers for Handling Big Geospatial Raster Data
Authors: Hu Fei , Xu Mengchao , Yang Jingchao , Liang Yanshou , Cui Kejin , Little Michael M. , Lynnes Christopher S. , Duffy Daniel Q. , Yang Chaowei
Published: April 2018

Big geospatial raster data pose a grand challenge to data management technologies for effective big data query and processing. To address these challenges, various big data container solutions have been developed or enhanced to facilitate data storage, retrieval, and analysis. Data containers were also developed or enhanced to handle geospatial data. For example, Rasdaman was developed to handle raster data and GeoSpark/SpatialHadoop were enhanced from Spark/Hadoop to handle vector data. However, there are few studies to systematically compare and evaluate the features and performances of these popular data containers. This paper provides a comprehensive evaluation of six popular data containers (i.e., Rasdaman, SciDB, Spark, ClimateSpark, Hive, and MongoDB) for handling multi-dimensional, array-based geospatial raster datasets. Their architectures, technologies, capabilities, and performance are compared and evaluated from two perspectives: (a) system design and architecture (distributed architecture, logical data model, physical data model, and data operations); and (b) practical use experience and performance (data preprocessing, data uploading, query speed, and resource consumption). Four major conclusions are offered: (1) no data containers, except ClimateSpark, have good support for the HDF data format used in this paper, requiring time- and resource-consuming data preprocessing to load data; (2) SciDB, Rasdaman, and MongoDB handle small/mediate volumes of data query well, whereas Spark and ClimateSpark can handle large volumes of data with stable resource consumption; (3) SciDB and Rasdaman provide mature array-based data operation and analytical functions, while the others lack these functions for users; and (4) SciDB, Spark, and Hive have better support of user defined functions (UDFs) to extend the system capability.
MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis
Authors: Yokoyama Yuka , Mise Nathan , Suzuki Yuka , Tada-Oikawa Saeko , Izuoka Kiyora , Zhang Lingyi , Zong Cai , Takai Akira , Yamada Yoshiji , Ichihara Sahoko
Published: April 2018

Smoking increases the risk of atherosclerosis-related events, such as myocardial infarction and ischemic stroke. Recent studies have examined the expression levels of altered microRNAs (miRNAs) in various diseases. The profiles of tissue miRNAs can be potentially used in diagnosis or prognosis. However, there are limited studies on miRNAs following exposure to cigarette smoke (CS). The present study was designed to dissect the effects and cellular/molecular mechanisms of CS-induced atherosclerogenesis. Apolipoprotein E knockout (ApoE KO) mice were exposed to CS for five days a week for two months at low (two puffs/min for 40 min/day) or high dose (two puffs/min for 120 min/day). We measured the area of atherosclerotic plaques in the aorta, representing the expression of miRNAs after the exposure period. Two-month exposure to the high dose of CS significantly increased the plaque area in aortic arch, and significantly upregulated the expression of atherosclerotic markers (VCAM-1, ICAM-1, MCP1, p22phox, and gp91phox). Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice. Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant. The results suggest that CS induces atherosclerosis through increased vascular inflammation and NADPH oxidase expression and also emphasize the importance of miRNAs in the pathogenesis of CS-induced atherosclerosis. Our findings provide evidence for miRNAs as potential mediators of inflammation and atherosclerosis induced by CS.