bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Trichomonas tenax in the Population Affected by Periodontal Disease – a Review
Authors: Stoyanov Stoyan Nikolov , Tasinov Oskan Bahidinov , Dimitrova Tsonka Slavova , Yaneva Galina Aleksieva
Published: February 2024

Background and Objectives: Trichomonas tenax is a protozoan, participating in the human oral microflora. It is considered as a potential paradontopathogen. This microorganism is also reported in the respiratory tract. We aimed to analyze the available literature about the prevalence of Trichomonas tenax in the population affected by periodontal disease. Materials and Methods: Тhe searching with keywords: ,,Trichomonas tenax” and “periodontal diseases’’ in Scopus, PubMed and ScienceDirect databases was able to identify several systematic reviews and original articles until July 2023. All studies with suffering from periodontal disease people, mentioned year of publication, country, specified detection methods, total number of tested samples as well as the percentage of those infected with Trichomonas tenax were included. Irrelevant articles were excluded. Results: We found 137 studies, but only 64 studies about distribution of Trichomonas tenax in patients with gum disease underwent qualitative analysis. The highest number of studies have been conducted in Iran, Poland and Iraq. Different methods have been used to detect the unicellular organism, each with different specificity and sensitivity. Conclusions: Interest in Trichomonas tenax has grown considerably since 2000. Because of its association with periodontal disease, Trichomonas tenax role in the inflammatory process shouldn’t be overlooked.
Building a ViT-Based Damage Severity Classifier with Ground- Level Imagery of Homes Impacted by California Wildfires
Authors: Luo Kevin , Lian Ie-bin
Published: February 2024

The rise in both the frequency of natural disasters and the ubiquity of artificial intelligence has led to novel applications of new technologies in improving disaster response processes, such as the labor-intensive assessment of disaster damages. Assessment of residential and commercial structure damages, a precursory step to government agencies being able to provide most of their financial assistance, has benefited from aerial and satellite imagery-based computer vision models; however, limitations of using such imagery include the ground structures being obscured by clouds or smoke, as well as the lack of resolution to distinguish individual structures from others. Using a different data source, we propose a damage severity classification model using ground-level imagery, focusing on residential structures damaged by wildfires. This classifier, a Vision Transformer (ViT) model trained on over 18,000 professionally labeled images of damaged homes from the 2020-2022 California wildfires, has achieved an accuracy score of over 95%. Further, we have open sourced the training dataset–the first of its kind and scale–as well as built a publicly available web application prototype, which we demoed to and received feedback from disaster response officials, both of which further contribute to the broader literature beyond the proposed model.
Serendipitous Identification of Azine Anticancer Agents by a Privileged Scaffold Morphing Strategy
Authors: Cesarini Silvia , Vicenti Ilaria , Poggialini Federica , Filippi Silvia , Mancin Eleonora , Fiaschi Lia , De Marchi Elisa , Giammarino Federica , Vagaggini Chiara , Bizzarri Bruno Mattia , Saladino Raffaele , Dreassi Elena , Zazzi Maurizio , Botta Lorenzo
Published: February 2024

The use of privileged scaffolds as starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development. Scaffold decoration, morphing and hopping are additional techniques that allow to modify the privileged framework chosen and better explore the chemical space around it. In this study, two series of highly functionalized pyrimidine and pyridine derivatives were synthesized by scaffold morphing approach of triazine compounds obtained previously as antiviral agents. Newly synthesized azines were evaluated against lymphoma, hepatocarcinoma, and colon epithelial carcinoma cells showing in five cases acceptable to good anticancer activity associated to low cytotoxicity on healthy fibroblasts. Finally, ADME in vitro studies were conducted on the best derivatives of the two series showing good passive permeability and resistance to metabolic degradation.
A Comprehensive State-of-the-Art Survey on Green Hydrogen Economy in Sub-Saharan Africa
Authors: Nnachi Gideon Ude , Richards Coneth Graham , Hamam Yskandar
Published: February 2024

Rapid increase in urbanization and industrialization due to increase in human population has led to increase in global warming resulting to climate change that affects the ecosystem. Unusual natural disasters such as cyclones, storms, floods, weather fluctuations, rising seal levels, transitional ecosystems and coastal disruptions are major adverse effects of climate change. There are huge worrisome concerns and uncertainties about the future of the planet earth due to climate change caused by high carbon emissions. Global aggressive policies in control of Carbon-dioxide (CO2) emissions from several combustion mechanisms have paved way for alternative/ clean energy sources. Green hydrogen is a promising means of clean energy sources for commercial power generation stations and other crucial systems such as hydrogen fuel cell vehicles (HFCVs) , motors, drives, backup power for buildings, and also serving as a source of electrical energy for remote locations. The goal of this study is to review the current level of Sub-Saharan African nations’ preparedness to adopt green hydrogen as a way to mitigate local energy supply issues and strengthen their individual economies.
Generative Artificial Intelligence in Chemistry Problem Solving across Versions and Languages
Authors: Daher Wajeeh , Diab Hussam , Rayan Anwar
Published: February 2024

Generative artificial intelligence tools are flourishing across various sciences, particularly in the educational domain. ChatGPT, with its versions 3.5 and 4.0, stands out for its multilingual capabilities, catering to both students and educators. This research aimed to evaluate the performance differences between these versions, and importantly, to compare the accuracy of ChatGPT's responses in English versus Arabic. In our study, we presented ChatGPT with 39 chemistry problems related to 6th-7th grade curriculum, including twenty-five open questions and fourteen multiple-choice questions. Each response was categorized as accurate, partially accurate, or inaccurate. Our analysis, focused on trends across versions and languages, revealed significant enhancements in version 4.0, particularly in its ability to process Arabic. However, despite these improvements, our findings indicate that responses in English consistently outperformed those in Arabic in terms of accuracy. In light of this discrepancy, we suggest that ChatGPT either incorporates additional Arabic databases into its training regimen or develops a code that adopts the following strategy to ensure more accurate responses in science education: questions should first be translated from Arabic to English, addressed, and then retranslated into Arabic before being presented to the user. This approach takes advantage of the greater accuracy of responses in English to benefit Arabic-speaking users, and it may also improve outcomes for speakers of other languages who experience less precise answers in the fields of chemistry or science education.
Safety of Dual Orexin Receptor Antagonist Daridorexant: A Dispropor-tionality Analysis of Publicly Available FAERS Data
Authors: Cicala Giuseppe , Barbieri Maria Antonietta , Russo Giulia , Salvo Francesco , Spina Edoardo
Published: February 2024

Daridorexant, as the first Dual Orexin Receptor Antagonist (DORA) marketed in Europe, offers a novel therapeutic approach to insomnia. However, data regarding its real-world safety are scarce. Thus, the aim of this study was to assess its safety profile using a large-scale pharma-covigilance database. Daridorexant-related Adverse Drug Reaction (ADR) reports from the FDA Adverse Event Reporting System were scrutinized, and ADRs were selected using reporting odds ratio (ROR) as a measure of disproportionality. Frequencies of events related to daridorexant were compared to all other drugs (reference group, RG1) and only to other DORAs (RG2). Only significant disproportionalities to both RGs were evaluated in-depth. A total of 845 dari-dorexant-related reports were selected; nightmares (n = 146; Dari vs. RG1: ROR = 113.74; 95%CI[95.13, 136]; Dari vs. RG2: ROR = 2.35; 95CI%[1.93, 2.85]), depression (n = 22; Dari vs. RG1: 2.13; [1.39, 3.25]; Dari vs. RG2: ROR = 2.31; 95CI%[1.45, 3.67]), and hangover (n = 20; Dari vs. RG1: ROR = 127.92; 95CI%[81.98, 199.62]; Dari vs. RG2: 3.38; [2.04, 5.61]) were considered as safety signals. These data provide valuable insights into the real-world safety profile of dari-dorexant, supporting the existence of safety signals related to nightmares, depression, and hang-over.
Study Circles as a Possible Arena to Support Self-Care – A Swedish Pilot Study
Authors: Kerstis Birgitta , Herlofson Jorgen , Wiklund Gustin Lena
Published: February 2024

Today, issues related to people’s mental health and well-being have been described as a challenge for society, globally as well as in Sweden. This calls for new approaches to mental health promotion. The aim was to evaluate the adequacy of the content and structure, describing experiences of study circles as a means of supporting participants' self-care and self-compassion. The overall design is a descriptive, QUAL+quan design, where quantitative and qualitative results are integrated. Five participants participated in a focus group interview, of whom four completed questionnaires. One individual interview was conducted with the study circle leader. Study circles can be an arena for mental health promotion as learning and sharing of experience contributes to a sense of coherence, as well as self-compassion and a genuine concern for one’s own and others' wellbeing, but not considered an alternative to psychiatric care, for those in need of professional services. Study circles can be a possible means to support self-care and thereby promote mental health in the general population, and a valuable contribution to public health. However, in addition to modifications of the content, further research is needed on the qualifications for study circle leaders as well as the dissemination of study circles.
Identification of Functional Genetic Variants in B4GALNT2 Gene and Their Association with Growth Traits in Goat
Authors: Xu Liang , Chen Zitong , Chen Shuheng , Chen Yu , Guo Jiazhong , Zhong Tao , Wang Linjie , Zhan Siyuan , Li Li , Zhang Hongping , Cao Jiaxue
Published: February 2024

B4GALNT2 is a vital candidate gene that affects the growth traits litter size in and growth traits of sheep, but whether it has the same function in goats remains to be further investigated. In this study, we utilized 348 Nanjiang Yellow goats as experimental subjects, conducted a whole exon, and the conserved the non-coding region SNP scanning of the B4GALNT2 gene. Our results revealed the presence of a synonymous mutation, rs672215506, within the exon of the B4GALNT2 gene in the Nanjiang Yellow goat population. This mutation was found to be associated with reduced mRNA stability of the B4GALNT2 gene. The results of SNPs detection of conserved non-coding region of B4GALNT2 gene showed that there were five potential regulatory SNPs in the Nanjiang Yellow goat population, except for rs66095343, the ~500 bp fragments of four SNPs (rs649127714, rs649573228, rs652899012 and rs639183528) could significantly increase luciferase activity both in goat skeletal muscle cells and 293T cells . Genetic diversity indexes indicated low or intermediate levels for all six SNPs analyzed, each conforming to Hardy-Weinberg equilibrium regarding genotypic frequencies. Association analysis indicated that rs660965343, rs649127714 and rs649573228 were significantly correlated with growth traits in the later stage of growth and development of Nanjiang Yellow goat. The haplotype combinations of H2H3 and H2H2 had higher body weight and greater body size; moreover, H2H2 haplotype combinations were significantly correlated with the litter size of Nanjiang Yellow goat. The results of our study demonstrate the potential utility of the B4GALNT2 gene as a functional genetic marker in breeding programs for Nanjiang Yellow goats.
True Benefits of Immune Checkpoint Inhibitors in the Treatment of Malignant Pleural Mesothelioma in Japan
Authors: Kuribayashi Kozo , Hirano Jun
Published: February 2024

In February 2004, the Food and Drug Administration (FDA) was the first to approve the combination of cisplatin (CDDP) and pemetrexed (PEM) as standard first-line chemotherapy for untreated, unresectable malignant pleural mesothelioma (MPM). However, after that approval, no progress was made in the standard first-line treatment of MPM for almost 15 years. Positive results from a phase 3 study (Mesothelioma Avastin Cisplatin Pemetrexed Study: MAPS) verifying the effect of bevacizumab, an anti-angiogenesis agent added to CDDP/PEM for unresectable MPM, were published in The Lancet in December 2015; however, this did not lead to approval by national drug regulatory agencies. Furthermore, no second-line treatment was established for cases refractory to CDDP/PEM. In August 2018, the Pharmaceuticals and Medical Devices Agency of Japan was the first in the world to approve monotherapy with nivolumab, an immune checkpoint inhibitor (ICI), for previously unresectable, advanced, or recurrent MPM. Following Japan, in October 2020, the FDA approved the combination of nivolumab and ipilimumab for the treatment of previously untreated, unresectable MPM. In this article, we review the transition of drug treatment for MPM, in light of the historical background, focusing on the benefits of ICIs.
Development of n-type, Passivating Nanocrystalline Silicon Oxide (nc-SiOx:H) Films via PECVD
Authors: Kaur Gurleen , Olivares Antonio J. , Roca i Cabarrocas Pere
Published: February 2024

Nanocrystalline silicon oxide (nc-SiOx:H) is a multipurpose material with its varied application in solar cells as a transparent front contact, intermediate reflector, back reflector layer and even tunnel layer for passivating contacts, owing to easy tailoring of its optical properties. In this work, we systematically investigate the influence of gas mixture (SiH4, CO2, PH3 and H2), RF power and process pressure on the optical, structural and passivation properties of thin n-type nc-SiOx:H films prepared in an industrial, high throughput, plasma-enhanced chemical vapor deposition (PECVD) reactor. We provide a detailed description of the n-type nc-SiOx:H material develop-ment using various characterization techniques (SEM, EDX, Raman spectroscopy, and spectro-scopic ellipsometry) with a focus on the relationship between the material properties and the pas-sivation they provide to n-type c-Si wafers characterized by their effective carrier lifetime (τeff). Further, we also outline the parameters to be kept in mind while developing different n-type nc-SiOx:H layers for different solar cell applications. We report a tunable optical gap (1.8 – 2.3 eV) for our n-type nc-SiOx:H films as well as excellent passivation properties with τeff up to 3.5 ms (iVoc ~ 715 mV) before annealing. Oxygen content plays an important role in determining the crystallinity and hence passivation quality of the deposited nanocrystalline silicon oxide films.
All-in-One Cost-Efficient Geodetic Station with Real-Time Transmission for Geodynamics Applications
Authors: Vidal Maurin , Jarrin Paul , Rolland Lucie M. , Nocquet Jean Mathieu , Vergnolle Mathilde , Sakic Pierre
Published: February 2024

GNSS is nowadays a standard tool for monitoring and studying the Earth’s dynamic environment. However, the development of dense GNSS measurements remains limited in many experiments by the cost of geodetic-class equipments allowing to achieve the high precision required by many applications. Recently, multi-constellation, multi-frequency, low-power and, above all, less expensive GNSS electronic chips have become available. We present a prototype of a low-cost, open-source multi-GNSS station. Our prototype comprises a dual-frequency GNSS chip, a calibrated antenna, a Raspberry Pi card and a 4G key for data transmission. The system is easy to deploy in the field and allows precise positioning in real time and post-processing. We assess the performance of our prototype in terms of raw data quality, and quality of the obtained high rate and daily position one-year-long time series. Our results demonstrate a quality equivalent to geodetic-class equipment and better quality than other low-cost systems proposed so far.
The Use of Clear Aligners in Multi-segmental Maxillary Surgery: A Case Control Study in Cleft Lip and Palate and Skeletal Class III Patients
Authors: Meazzini Maria Costanza , Demonte Leonardo Paolo , Cohen Noah , Battista Valeria Marinella Augusta , Rabbiosi Dimitri , Autelitano Luca
Published: February 2024

Introduction: maxillary hypoplasia and mandibular asymmetry may be corrected with orthognathic surgery at the completion of growth. Many patients require segmental Le Fort I osteotomies to obtain the most stable results. Unfortunately, if Invisalign is chosen for pre-surgical preparation, ClinCheck © software does not allow for prediction when these complex surgeries are planned. The objective of this paper was to show the potential of aligners beyond its software in most complex cases like multiple-piece maxillary osteotomies in cleft and non-cleft patients. Method: Thirteen patients who underwent pre-surgical treatment with clear aligners-Invisalign (study group) were matched in terms of diagnosis, surgical procedure, and orthodontic complexity with thirteen patients treated using fixed appliances (control group). A technique based on simple superimposition was devised to enhance the software for creating a suitable occlusion for segmental pre-surgical treatments. Virtual curves following the lower arch were employed to guide the correct pre-surgical positions of the upper teeth. The amount of impressions required in both groups to achieve satisfactory pre-surgical alignment of the segmented arches was compared. Results: one or no refinement phase were needed in the Invisalign group to reach an acceptable pre-surgical occlusion while the amount of pre-surgical impressions taken in order to reach adequate coordination with fixed appliance treatment was slightly higher. The average overall treatment duration did not show a statistically significant variation between the groups. Conclusions: it appears that clear aligner could serve as an effective treatment for individuals with skeletal discrepancies, including cleft and craniofacial anomalies, necessitating segmental Le Fort I osteotomies when aided by the suggested superimposition approach during digital pre-surgical movement simulations. More sophisticated softwares will certainly be implemented in the future.
Evaluation of the Oral Microbiome before and after Treatments for Halitosis with Photodynamic Therapy and Probiotics – Pilot Study
Authors: Motta Pamella de Barros , Gonçalves Marcela Leticia Leal , Gallo Juliana Maria Altavista Sagretti , Sobral Ana Paula Taboada , Motta Lara Jansiski , Santos Elaine Marcílio , Andrade David José Casimiro de , Duran Cinthya Cosme Gutierrez , Fernandes Kristianne Porta Santos , Mesquita-Ferrari Raquel Agnelli , Horliana Anna Carolina Ratto Tempestine , Bussadori Sandra Kalil
Published: February 2024

Background: To compare photodynamic therapy 41 and the use of probiotics in reducing halitosis assessed through gas chromatography and microbiome analysis. Methods: Participants aged from 18 to 25 years, showing sulfide (SH2) ≥ 112 ppb on gas chromatography, were selected. They were divided into 4 treatment groups: Group 1 - Tongue Scraping; Group 2- Antimicrobial Photodynamic Therapy (aPDT); Group 3- Probiotics; Group 4- Antimicrobial Photodynamic Therapy (aPDT) and Probiotics. The halimetry process was performed before, immediately after the treatments, 7 days, 14 days and 30 days after the initial collection. The collections for later microbiological analysis were made along with the halimetry, for the microbiome analysis. Results: Treatment with aPDT or probiotics under these experimental conditions was not able to change the bacteria present in the biofilm of the tongue. Conclusions: More research is needed to know the behavior of the oral microbiome in the presence of halitosis and the effectiveness of new treatments.
Climate Change and the Platypus: A Scientific Analysis
Authors: Mussies Martine
Published: February 2024

This paper explores the imminent threat posed by climate change to the unique platypus species. It delves into the ecological repercussions of global temperature rise and altered climate patterns on platypus habitats. The study emphasises the multifaceted impacts, including changes in aquatic habitat quality, food sources, and breeding rituals. Climate-induced shifts in phytoplankton spring blooms and anthropogenic pressures further endanger the platypus's habitat. The article stresses the importance of understanding these effects for both species conservation and anticipating broader ecological and socio-economic consequences. Mitigating climate change impacts requires a multidimensional approach, involving habitat manipulation and restoration strategies.
Development and Evaluation of an In-House Real-Time Rt-Pcr Targeting nsp10 Gene for SARS-CoV-2 Detection
Authors: Yip Cyril Chik-Yan , Poon Jane Hau-Ching , Leung Kit-Hang , Chan Wan-Mui , Ip Jonathan Daniel , Chu Allen Wing-Ho , Cheng Vincent Chi-Chung , Yuen Kwok-Yung , To Kelvin Kai-Wang
Published: February 2024

The emergence of SARS-CoV-2 mutations pose significant challenges to diagnostic tests as these mutations can reduce the sensitivity of commonly used RT-PCR assays. Therefore, there is a need to design diagnostic assays with multiple targets to enhance sensitivity. In this study, we identified a novel diagnostic target, nsp10 gene, using nanopore sequencing. Firstly, we determined the analytical sensitivity and specificity of our COVID-19-nsp10 assay. The COVID-19-nsp10 assay had the limit of detection of 74 copies/mL (95% confidence interval: 48-299 copies/mL) and did not show cross-reactivity with other respiratory viruses. Next, we determined the diagnostic performance of the COVID-19-nsp10 assay using 261 respiratory specimens, including 147 SARS-CoV-2-positive specimens belonging to ancestral strain and Alpha, Beta, Gamma, Delta, Mu, Eta, Kappa, Theta and Omicron lineages. Using the LightMix E-gene RT-PCR assay as the reference method, the diagnostic sensitivity and specificity of the COVID-19-nsp10 assay were 100%. The median Cp values for the LightMix E-gene RT-PCR and our COVID-19-nsp10 RT-PCR were 22.48 (range: 12.95-36.60) and 25.94 (range 16.37-36.87), respectively. The Cp values of the COVID-19-nsp10 RT-PCR assay correlated well with those of the LightMix E-gene RT-PCR assay (Spearman’s ρ = 0.968; P<0.0001). In conclusion, nsp10 is a suitable target for SARS-CoV-2 RT-PCR assay.
Incident Cancer Risk of Patients With Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)
Authors: Abonyi-Tóth Zsolt , Rokszin György , Sütő Gábor , Fábián Ibolya , Kiss Zoltán , Jermendy György , Kempler Péter , Lengyel Csaba , Wittmann István , Molnár Gergő A.
Published: February 2024

(1) Background: Among the chronic complications of type 2 diabetes mellitus, cancer became the leading cause of death in several countries. Our objective was the determination of whether prevalent type 2 diabetes mellitus is associated with a higher incidence of cancer. (2) Methods: This study is a nationwide analysis performed in Hungary. Study population was divided into a group with type 2 diabetes mellitus and into a non-diabetic group. The primary outcome was the risk related to overall cancer incidence. A key secondary outcome was the overall incidence of cancer in distinct study years. Further outcomes were the annual percent changes. (3) Results: The odds ratio related to the overall incidence of cancer was 2.50 (95% confidence interval: 2.46-2.55, P<0.0001) in patients with diabetes as related to controls. The odds ratio was higher in males than in females. The highest risk was found in the 18-39-year-old subgroup. The annual cancer incidence rate declined in controls, but not in patients with diabetes. Several types of cancer showed a decreasing tendency in non-diabetic controls.; (4) Conclusions: type 2 diabetes is associated with a higher risk of cancer. High risk in young patients with type 2 diabetes suggests that these young individuals should be considered as a risk group.
Optimizing Stainless Steel Bearings: The Impact of Low-Temperature Forming on Bearing Life
Authors: Bodewig Alexander Heinrich , Pape Florian , Poll Gerhard
Published: February 2024

A proposed low-temperature forging method aims to enhance stainless steel bearings by creating a martensitic subsurface layer, significantly boosting bearing fatigue life due to increased surface hardness. This technique induces beneficial residual stresses, particularly in axial bearings, streamlining their construction and improving machine elements. Challenges persist, especially with radial bearings, but simplicity in axial bearing forging promotes compact, resource-efficient facility construction. Future research will focus on applying this technique to axial bearing washers, potentially replicating success in other bearing components. Despite the energy ex-penditure for cooling during forging, the substantial increase in bearing fatigue life offsets this, enhancing overall longevity and reliability of critical machine components. Integration of this forging technique into bearing fabrication appears seamless, offering a promising trade-off be-tween energy use and enhanced performance.
Dendritic Cells Immunotherapy of Ovarian Cancer: Overview of Our Achievements
Authors: Bartůňková Jiřina
Published: February 2024

Abstract
Epithelial ovarian carcinoma (EOC) is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. EOC is poorly responsive to immune check-point inhibitors due to immunologic features including limited tumor mutational burden (TMB), poor infiltration by immune cells and active immunosuppression. Thus, novel strategies are needed to overcome the frequent lack of preexisting immunity in patients with EOC. We developed and tested an autologous dendritic cell (DC)-based vaccine (DCVAC) which has recently been shown to be safe and to significantly improve progression-free survival (PFS) in two independent randomized phase II clinical trials enrolling patients with EOC (SOV01, NCT02107937; SOV02, NCT02107950). In addition, our exploratory data analyses suggest that the clinical benefits of DCVAC were more pronounced in patients with EOC with lower than-median TMB and scant CD8+ T cells infiltration. Thus, DC-based vaccine stands out as a promising clinical tool to jumpstart anticancer immunity in patients with immunologically „cold“ EOC. Our findings underscore the need for personalized immunotherapy and clinical relevance of potential tumor-related biomarkers within immunotherapy field. Additional clinical trials are needed to address these strategies as well as the potential value of TMB and immune infiltrate at baseline as biomarkers to guide the clinical management of EOC.
Improving Device-to-Device Reproducibility of Light-Emitting Diodes Based on Layered Halide Perovskites
Authors: Do Quang-Huy , Antony Rémi , Ratier Bernard , Bouclé Johann
Published: February 2024

Layered halide perovskites have emerged as a promising contender in solid-state lighting thanks to their tunable bandgap, high luminescence quantum yield, and high color purity. However, the fabrication of perovskite light-emitting devices in laboratories usually experiences low de-vice-to-device reproducibility since perovskite crystallization is highly sensitive to ambient condi-tions, such as humidity and temperature. Although device processing inside gloveboxes is primarily used to reduce the influence of oxygen and moisture, several extraneous variables, including gas-eous pollution traces and thermal fluctuations in the inert atmosphere or contaminations from re-sidual solvents confined in the enclosed environment, can destabilize the crystallization process and alter the properties of the emissive layers. Here, we examine different experimental set-ups for spin-coating deposition of layered perovskites in inert atmospheres and their influences on the formation of polycrystalline thin films. Our results demonstrate that fluctuations in the glovebox properties (concentrations of residual O2 and H2O or solvent traces), even in very short timescales, can negatively impact the consistency of the perovskite film formation, while thermal variation plays a relatively minor role in this phenomenon. Furthermore, careful storage of chemical species inside the workstation is critical for reproducing high-quality perovskite layers. Consequently, when applying our most controlled environment for perovskite deposition, the photoluminescence life-time of perovskite thin films shows a standard deviation of only 3%, whereas the reference set-up yields a 15% standard deviation. Regarding complete perovskite light-emitting diodes, the uncer-tainties in statistical luminance and EQE data are significantly reduced from 230% and 140% to 38% and 42%, respectively.
Use of HSI Coupled with Machine Learning for the Identification of Water Stress in Pear Seedling Leaves
Authors: An Andrea , Wang Ran
Published: February 2024

Water plays a vital role in the healthy growth of pears. Early detection of water stress can play a significant role in the timely management of water deficiency for pear yield. Most current methods are labour-intensive, time-consuming, only provide point measurements, and could be destructive. In this research, a real-time non-destructive method using a push-broom hyperspectral system (400-1000nm) was used to collect hyperspectral image data and detect the water stress of the pear seedling leaves. To build a reliable prediction model, machine learning techniques were used. The Successive Projections Algorithm (SPA) was applied for optimal wavelength selection. In particular, CNN was applied to obtain the features of key wavelengths. Both the CNN features and key wavelengths were put into RR-MLR, BLR and ENN for analysis. The training accuracy of the three modellings all reach the accuracy above 70% after about 100 epochs, while combination of CNN features outperformed the mere main spectra analysis. This research demonstrated that hyperspectral imaging coupled with machine learning techniques could be applied to predict the water content of pear leaves predict non-destructively.
Exploring the Gut-Mitochondrial Axis: the p66Shc Adapter Protein and Its Implications for Metabolic Disorders
Authors: Da C. Pinaffi-Langley Ana Clara , Melia Elizabeth , Hays Franklin A
Published: February 2024

This review investigates the multifaceted role of the p66Shc adaptor protein and the gut microbiota in regulating mitochondrial function and oxidative stress, and their collective impact on the pathogenesis of chronic diseases. The study delves into molecular mechanisms by which p66Shc influences cellular stress responses through Rac1 activation, Forkhead-type transcription factors inactivation, and mitochondria-mediated apoptosis, alongside modulatory effects of gut microbiota-derived metabolites and endotoxins. Employing an integrative approach, the review synthesizes findings from a broad array of studies, including molecular biology techniques and analyses of microbial metabolites' impacts on host cellular pathways. The results underscore a complex interplay between microbial metabolites, p66Shc activation, and mitochondrial dysfunction, highlighting the significance of the gut microbiome in influencing disease outcomes through oxidative stress pathways. Conclusively, the review posits that targeting the gut microbiota-p66Shc-mitochondrial axis could offer novel therapeutic strategies for mitigating the development and progression of metabolic diseases. This underscores the potential of dietary interventions and microbiota modulation in managing oxidative stress and inflammation, pivotal factors in chronic disease etiology.
A Rare Case of Dirofilariosis in the Genian Region
Authors: Nicolau Andrei , Sava Florin Petrică , Severin Florentina , Ciofu Mihai Liviu , Ferariu Dan , Dodu Daniela , Costan Victor Vlad
Published: February 2024

Dirofilariosis is an infectious disease caused by species of the Dirofilaria genus. It is manifested by the appearance of a subcutaneous swelling, especially in the eye region. We present the case of a 29-year-old patient that accused facial asymmetry in the right genian region. Following clinical and paraclinical evaluations, the diagnosis of parasitic cyst was established in the context of dirofilariosis with Dirofilaria repens (D. repens). Treatment consisted of surgical excision of the formation associated with prophylactic antibiotic medication. Macroscopic analysis of the excision piece revealed a structure that contains a cystic cavity and a filamentous form with a length of approximately 10 mM and a diameter of 1 mM. This is the first case of dirofilariosis located in the genian region reported in Romania. The overview of this pathology is important to raise awareness among physicians about its presence and its clinical variations.
Pengaruh Service Quality, Brand Trust dan Customer Satisfaction terhadap Loyalty pada Pengguna Jasa Pembayaran Online
Authors: Oktavian Sandy , Suhud Usep , Febrilia Ika
Published: February 2024

ABSTRACT

The purpose of this study is to test whether brand reputation and transaction safety have a positive effect on brand trust. And to test service quality, brand trust, and customer satisfaction have a positive effect on customer loyalty for users of Lazada online shop pay later services. The data collection method used a survey method with the instrument in the form of a questionnaire. The object of this research is 240 respondents who have used the Lazada application service. Technical data analysis using SEM to process and analyse research data. The results of the study show that: 1) service quality has a positive effect on customer loyalty; 2) customer satisfaction has a positive effect on customer loyalty. 3) brand reputation has a positive effect on brand trust; 4) transaction safety has a positive effect on brand trust; 5) brand trust has a positive effect on customer loyalty.

Keywords: Brand Reputation, Transaction Safety, Service Quality, Brand Trust, Customer Satisfaction, Customer Loyalty.

 

ABSTRAK

Tujuan dari penelitian ini adalah untuk menguji apakah brand reputation dan transaction safety berpengaruh positif terhadap brand trust. Dan untuk menguji service quality, brand trust dan customer satisfaction berpengaruh positif terhadap customer loyalty bagi pengguna jasa pay later online shop Lazada. Metode pengumpulan data menggunakan metode survey dengan instrument berupa kuesioner. Objek penelitian ini adalah 240 responden yang sudah menggunakan layanan aplikasi Lazada. Teknis analisis data menggunakan SEM untuk mengolah dan menganalisis data hasil penelitian. Hasil penelitian menunjukan bahwa : 1) service quality berpengaruh positif terhadap customer loyalty; 2) customer satisfaction berpengaruh positif terhadap customer loyalty. 3) brand reputation berpengaruh positif terhadap brand trust; 4) transaction safety berpengaruh positif terhadap brand trust; 5) brand trust berpengaruh positif terhadap customer loyalty..

Kata kunci: Brand Reputation, Transaction Safety, Service Quality, Brand Trust, Customer Satisfaction, Customer Loyalty
Escolhas públicas, compliance e juridicidade administrativa
Authors: Santos Marcelo Pereira dos , Lima Marcelo Machado Costa
Published: February 2024

Partindo-se do pressuposto que uma administração proba e eficiente é um direito fundamental do cidadão brasileiro, este artigo tem por propósito de descrever as possíveis consequências da implementação de sistemas de compliance nas esferas da Administração direta, responsáveis pela formulação das escolhas públicas, de modo a aprimorar os atos de gestão e promover a transparência no âmbito dos processos decisórios. O trabalho foi elaborado com base no referencial teórico estabelecido pelo Prof. Diogo de Figueiredo Moreira Neto, alusivo ao direito administrativo do século XXI e a relação entre sociedade, Estado e Administração Pública. Para obter os resultados apresentados neste trabalho, os autores se valeram da metodologia dialético-descritiva, desenvolvendo um pensamento sistematizado em torno dos paradigmas, conceitos e interpretações concebidas pela doutrina nacional e estrangeira sobre a juridicidade administrativa. Nas conclusões preliminares, ficaram destacados os desdobramentos do compliance no plano das escolhas públicas, concernente à ampliação das fronteiras democráticas para o gerenciamento eficiente dos recursos disponíveis, em favor da efetivação dos direitos fundamentais.
Chicken Sausage Production Process at PT. X
Authors: Kiranti Irma , Hudi Lukman , Pradiko Rifky
Published: February 2024

This study investigated the chicken sausage production process and explored problem-solving strategies using fishbone diagrams. The analysis identified key stages, including raw material preparation, grinding, mixing, molding, cooking, cooling, cutting, and packaging. Fishbone diagrams were employed to systematically dissect process issues, revealing root causes related to personnel, methods, machines, materials, and environment. The findings highlight the effectiveness of fishbone diagrams for identifying and addressing production bottlenecks, paving the way for optimized efficiency and quality control in sausage manufacturing.
Highlights :

Process breakdown: The study identified key stages in chicken sausage production (preparation, grinding, mixing, etc.) using fishbone diagrams.
Root cause analysis: Fishbone diagrams helped pinpoint root causes of process issues across various factors (personnel, methods, machines, etc.).
Quality improvement: The findings suggest fishbone diagrams as an effective tool for identifying and addressing bottlenecks, leading to optimized efficiency and quality control.

Keywords: chicken sausage, production process, fishbone diagrams, problem-solving, quality control
Apllication Of The Moving Average Forecasting Method In Masonry Concrete Sales
Authors: Romi Mochammad , Putra Boy Isma
Published: February 2024

This study aims to create a concrete sales forecasting system using the moving average method to predict sales for the next month in order to determine the amount of production that must be supplied in the next period. The study uses the moving average method which is widely used and has accuracy in forecasting. The results obtained mean error of 32630.95, MAD of 224532, MSE of 80977550000, standard error of 318154, Mape of 12.621% and average forecast of 1960074.0. The study implies that the moving average method is an effective tool for sales forecasting and can be used to make informed decisions about production planning and estimating future growth Highlight : The study aims to create a concrete sales forecasting system using the moving average method. The moving average method is an effective tool for sales forecasting and can be used to make informed decisions about production planning and estimating future growth. The study provides statistical measures such as mean error, MAD, MSE, standard error, and MAPE to evaluate the accuracy of the moving average method. Keywords: Sales forecasting, Moving average method, Production planning, Accuracy, Informed decisions.
Asya Ülkelerinin İnovasyon Performanslarının CILOS Temelli CoCoSo Yöntemi ile Değerlendirilmesi
Authors: ŞAHİN MACİT Nazife
Published: February 2024

Bu çalışmanın amacı 2022 yılına ilişkin Küresel İnovasyon İndeksi raporunda yer alan veriler ve bileşenler dikkate alınarak 39 Asya ülkesinin inovasyon performanslarını CILOS ve CoCoSo yöntemleri ile değerlendirmek ve sıralamaktır. Diğer taraftan CILOS temelli CoCoSo yöntemi analizi sonucu ortaya çıkan ülkelerin performans sıralamaları ile Küresel İnovasyon İndeksi raporundaki sıralamaları karşılaştırılmalı bir şekilde ele almaktır. Bu amaçlar doğrultusunda Küresel İnovasyon İndeksi’nde yer alan yedi bileşen (kurumlar, beşeri sermaye ve araştırma, altyapı, pazar gelişmişliği, iş gelişmişliği, bilgi ve teknoloji çıktıları, yaratıcılık çıktıları) kriter olarak çalışmaya dahil edilmiştir. Kriterlerin ağırlıklandırılması CILOS yöntemi ile yapılmış ve en önemli kriterin altyapı olduğu ortaya çıkmıştır. İnovasyon performansı açısından ülkelerin değerlendirilmesi ise CoCoSo yöntemi ile gerçekleştirilmiş ve en yüksek performans sergileyen dört ülkenin sırasıyla Singapur, Kore, Japonya ve Çin olduğu tespit edilmiştir. Ayrıca CILOS temelli CoCoSo yöntemi analizi sonucunda ortaya çıkan sıralamalar ile KİE raporundaki sıralamalar arasında anlamlı ve pozitif yönde çok kuvvetli bir ilişkinin olduğu Spearman Rho Korelasyon testi sonucunda belirlenmiştir. Bu da araştırmada kullanılan CILOS temelli CoCoSo yöntemi ile ülkelerin inovasyon performanslarının değerlendirilebileceğini ortaya çıkarmıştır.
Graphene Oxide Decorated with Nickel Cobaltite Nanoparticles as an Adsorbent for Cationic Methyl Green Dye: Kinetic, Isotherm, and Thermodynamic Studies
Authors: Abduljabar Maryam Abdulsatar , Merza Sundus Hadi
Published: February 2024

‎تم في هذه الدراسة ، تزيين ‏رقائق أكسيد الجرافين (‏GO‏) بجسيمات ‏كوبلتيت النيكل النانوية ‏NiCo2O4‎‏(‏NC‏) عن طريق الترسيب في ‏الموقع ، وتم استخدام المتراكب ‏المحضر (‏NC: GO‏) كسطح ماز لإزالة ‏صبغة الميثيل الخضراء ( ‏MG‏) من ‏المحاليل المائية. تم التحقق من ‏التغطية الناجحة لأوكسيد الجرافين ‏بجزيئات كوبلتيت النيكل النانوية ‏‏(‏NC‏) باستخدام دراسات ‏FT-IR‏ وحيود ‏الأشعة السينية (‏XRD‏). كانت أحجام  ‏الجسيمات البلورية لل ‏NC‏ و ‏ لل ‏GO‏ المزين ب NCهي ‏‎10.53‎‏ نانوميتر ‏‏9.30 نانومتر على التوالي. تم دراسة ‏تأثير العديد من العوامل التجريبية ‏، بما في ذلك زمن التلامس ، وكمية ‏السطح الماز ، ودرجة الحرارة. كان ‏وقت التلامس الأمثل وكمية السطح 120 ‏دقيقة و 3 مجم / لتر على التوالي. ‏تتلائم بيانات الامتزاز بشكل أفضل مع ‏ايزوثيرم ‏Freundlich‏. تم استخدام ‏أربعة نماذج حركية لتتبع عملية ‏الامتزاز: معادلة زائفة من الدرجة ‏الأولى ، ومعادلة زائفة من الدرجة ‏الثانية ، ومعادلة الانتشار داخل ‏الجسيمات ، ومعادلة بويد. أظهرت ‏نمذجة البيانات التجريبية أن حركية ‏الامتزاز كانت ممثلة بشكل جيد ‏بنموذج الرتبة الثانية الزائفة (‏R2 ‎‎= 0.9945‎‏) مع معدل ثابت سرعة يبلغ 3.2 ‏‏× 10 - 3 (جم / مجم. دقيقة). يتم ‏امتصاص صبغة ‏MG‏ تدريجيًا بواسطة ‏الجسيمات النانوية ‏NC‏ من خلال ‏الانتشار داخل الجسيمات ويتم ‏الاحتفاظ بها بعد ذلك في مسام أصغر. ‏أظهرت قيم التحليل الديناميكي ‏الحراري أن عملية امتزاز صبغة ‏MG‏ ‏كانت ماصة للحرارة بطبيعتها ، و ‏تلقائية وعملية الامتزاز فيزيائية.
الكلمات المفتاحية: الانتشار داخل الجسيمات ، المسافات البينية، النموذج الزائف من الدرجة الأولى ، معادلة بويد
Determination of Quercetin in Iraqi Green Walnut Husk via Green Ionic Liquid-Based Digestion Extraction and Gel Filtration Procedures-Spectrophotometry and Microfluidic Paper-Based Analytical Platform Detection
Authors: Mohammad Murtadha A. , Abdulsattar Jwan Oday , Nasif Zaizafoon N. Nasif
Published: February 2024

في هذه الدراسة تم استخلاص ،عزل وتقدير الكيورستين الموجود في قشور الجوز العراقي باستخدام طريقة جديدة تعتمد على الاستخلاص بطريقة الهضم المبنية على استخدام السوائل الايونية و طريقة الترشيح بالجل للفصل المقترنة مع المطيافية الضوئية للتقدير ومن ثم مقارنتها مع تقنية جديدة تسمى تقنية السوائل المايكروية الورقية مستهدفة بناء طريقة اقتصادية، صديقة للبيئة وخضراء. ولقد تم اختيار 1 بيوتيل-3-مثيل ايمادزوليم كلورايد  كمذيب اخضر بديل للمذيبات التقليدية بسبب خصائصة الذوبانية .ولقد اظهرت النتائج ان 100 ملغرام من القشورتحتاج الى 15 مل من المذيب و30 دقيقة من الهضم عند درجة75°C كظروف مثلى لاعطاء افضل ناتج للمستخلص بطريقة الهضم مقارنه مع طرق الاستخلاص الاخرى .تحت هذه الظروف المثلى تم عزل الكيورستين باستخدام طريقة الترشيح بالجل وتم التاكد من المركب المعزول باستخدام تقنية كروموتوغرافيا السائل عالية الاداء و اشعة فورية تحت الحمراء .تم تقدير الكيورستين المعزول من المستخلص لونيا ( طريقة كلوريد الالمنيوم) باستخدام طريقتي المطيافية الضوئية و وتقنية السوائل المايكروية الورقية معطيا الخطية لمنحنيات المعايرة لكلتا الطريقيتين بين 10-100 مليغرام / لتر مع معامل ارتباط0.9369 و 0.7917 لكلتا الطريقتين.  ومن ثم تم تقدير الفعالية المضادة للاكسدة باستخجام طريقة قوة الاختزال للمركب المعزول مظهرة فعالية مضادة للاكسدة جيدة و بين تحليل التباين (ANOVA)  عدم وجود فرق كبير بين تقنية المطيافية الضوئية وتقنية السوائل المايكروية الورقية.  كخلاصة يمكن اعتبار المذيب الايوني  BMIMCLمذيبا امنا ومناسبا لاستخلاص المركبات النباتية ذات الخواص الطبية وكذلك فان تقنية السوائل المايكروية الورقية اثبتت مقدرتها على التحليل بكفاءة مساوية الى طرق التحليل التقليدية بالاضافة الى خصائصها الخضراء.
A New Strategy to Modify Hopfield by Using XOR Operation
Authors: Hasan Rusul Hussein
Published: February 2024

تعد شبكة هوبفيلد واحدة من أسهل الأنواع الشبكات العصبية، تركيب الشبكة يكون كل خلية عصبية في الشبكة تتصل بالخلية الأخرى، وبالتالي تسمى الشبكة العصبية المتصلة بالكامل. بالإضافة إلى ذلك، يعتبر هذا النوع ذاكرة ارتباطية تلقائية، نظرًا لأن الشبكة تقوم بإرجاع النمط فور التعرف عليه، فإن هذه الشبكة بها العديد من القيود، بما في ذلك سعة الذاكرة، والتباين، والمتعامد بين الأنماط، والاوزان المتماثلة، والحد الأدنى. هذا البحث يقترح استراتيجية جديدة لتصميم شبكة الهوبفيلد باستخدام عملية XOR ؛ حيث تم اقتراح إستراتيجية جديدة لحل هذه القيود من خلال اقتراح خوارزمية جديدة، باستخدام هذه الاستراتيجية سيزيد من تحسين  أداء شبكة الهوبفيلد من خلال تعديل بنية الشبكة، ومراحل التدريب والتقارب ، وان الاستراتيجية المقترحة تعتمد على حجم النمط. و تتجنب تعلم نمط مشابه عدة مرات، و تظهر قابليتها في التعرف على أنماط مشوهة بالضوضاء، وسعة تخزينها غير محدودة وحل مشكلة النمط المعكوس. أظهرت التجارب أن الطريقة المقترحة لها نتائج جيدة من خلال تجنب غالبية قيود شبكة هوبفيلد. بالإضافة إلى ذلك ، يتعلم التعرف على عدد لا حصر له من الأنماط بأحجام مختلفة مع الحفاظ على نسبة ضوضاء مناسبة.
Investigation of Fractional Order Tumor Cell Concentration Equation Using Finite Difference Method
Authors: Takale Kalyanrao , Kharde Uttam , Gaikwad Shrikisan
Published: February 2024

المعادلة التفاضلية الكسرية توفر إطارًا رياضيًا قويًا لنمذجة وفهم مجموعة واسعة من الظواهر المعقدة وغير المحلية والمعتمدة على الذاكرة في مختلف التطبيقات العلمية والهندسية والعالمية. تعد الاعتلالات الكبدية أورامًا سرطانية ثانوية تتطور في الكبد نتيجة انتشار خلايا السرطان منورام سرطاني أصلي ينشأ في جزء آخر من جسم الإنسان. التركيز الأساسي لهذه الدراسة هو فهم نمو الأورام في الكبد البشري، سواء بوجود أو بدون علاج دوائي. ولتحقيق ذلك، يتم استخدام معادلة تفاضلية جزئية معرفة بالترتيب الزمني والكسري، ويتم تحليلها باستخدام أساليب عددية. يتم استخدام المشتقة كابوتو لاستكشاف تأثير العلاج الدوائي على نمو الورم. لحل النموذج الرياضي عدديًا، تم تطوير طريقة الفروق المحدودة كرانك-نيكولسون. يتم اختيار هذه الطريقة بسبب خصائصها المميزة، بما في ذلك الاستقرار الغير مشروط والدقة من الدرجة الثانية في الأبعاد الزمنية والمكانية. الاستقرار والدقة التي توفرهما هاتان الخصائص أمران حاسمان لضمان موثوقية النتائج المحصلة في هذه البحث. يتم تقديم النتائج والتحققات المستمدة من هذه الدراسة بفعالية من خلال تمثيلات بصرية متنوعة. تعتبر هذه الوسائل البصرية أدوات لا غنى عنها لفهم التأثير العميق للعلاج الدوائي على نمو الأورام. من خلال هذا التمثيل البصري، يمكن للشخص الحصول على فهم أوضح وأكثر تفصيلًا للديناميات المعقدة التي تحدث. تم الوصول إلى الحل العددي لهذه المشكلة المعقدة من خلال تنفيذ خوارزميات تم تطويرها بدقة باستخدام لغة البرمجة بايثون المتعددة الاستخدامات والقوية. مرونة بايثون والمكتبات الشاملة وإمكانيات الحساب العددي القوية تجعلها الخيار المثالي للتعامل مع تعقيدات هذه الدراسة.