bluuebunny/crossref_metadata_2025 huggingface dataset:
IGF2BP3 as a Prognostic Biomarker in Well-Differentiated/Dedifferentiated Liposarcoma
Authors: Klingbeil Kyle D. , Tang Jack Pengfei , Graham Danielle S. , Lofftus Serena Y. , Jaiswal Amit Kumar , Lin Tasha L. , Frias Chris , Chen Lucia Y. , Nakasaki Manando , Dry Sarah M. , Crompton Joseph G. , Eilber Fritz C. , Rao Dinesh S. , Kalbasi Anusha , Kadera Brian E.
Published: September 2023

Background: Although IGF2BP3 has been implicated in tumorigenesis and poor outcomes in multiple cancers, its role in soft-tissue sarcoma (STS) remains unknown. Preliminary data have suggested an association with IGF2BP3 expression among patients with well-differentiated/dedifferentiated liposarcoma (WD/DD LPS), a disease where molecular risk stratification is lacking. Methods: We examined the survival associations of IGF2BP3 via univariate and multivariate Cox regression in three unique datasets: (1) the Cancer Genome Atlas (TCGA), (2) an in-house gene microarray, and (3) an in-house tissue microarray (TMA). A fourth dataset, representing an independent in-house TMA, was used for validation. Results: Within the TCGA dataset, IGF2BP3 expression was a poor prognostic factor uniquely in DD LPS (OS 1.6 vs. 5.0 years, p = 0.009). Within the microarray dataset, IGF2BP3 expression in WD/DD LPS was associated with worse survival (OS 7.7 vs. 21.5 years, p = 0.02). IGF2BP3 protein expression also portended worse survival in WD/DD LPS (OS 3.7 vs. 13.8 years, p < 0.001), which was confirmed in our validation cohort (OS 2.7 vs. 14.9 years, p < 0.001). In the multivariate model, IGF2BP3 was an independent risk factor for OS, (HR 2.55, p = 0.034). Conclusion: IGF2BP3 is highly expressed in a subset of WD/DD LPS. Across independent datasets, IGF2BP3 is also a biomarker of disease progression and worse survival.
Feasibility and Activity of Megestrol Acetate in Addition to Etoposide, Doxorubicin, Cisplatin, and Mitotane as First-Line Therapy in Patients with Metastatic/Unresectable Adrenocortical Carcinoma with Low Performance Status
Authors: Turla Antonella , Laganà Marta , Abate Andrea , Cremaschi Valentina , Zamparini Manuel , Chittò Matteo , Consoli Francesca , Alberti Andrea , Ambrosini Roberta , Tamburello Mariangela , Grisanti Salvatore , Tiberio Guido Alberto Massimo , Sigala Sandra , Cosentini Deborah , Berruti Alfredo
Published: September 2023

(1) Background: The standard first-line therapy for advanced adrenocortical carcinoma (ACC) is represented by EDP-M (etoposide, doxorubicin, cisplatin + mitotane). Progestins have shown cytotoxic activity both in vitro and in vivo on ACC; better EDP-M tolerability and efficacy have been hypnotized due to the association with progestins. (2) Methods: The feasibility and tolerability of EDP-M combined with oral megestrol acetate (EDP-MM) were tested in 24 patients (pts) affected by metastatic ACC with a low performance status (PS); the case group was compared with a 48 pts control group according to the propensity score. The secondary objectives were clinical benefit rate (CBR), progression-free survival (PFS), and overall survival (OS). (3) Results: Thirteen pts (54.2%) in the EDP-MM population experienced progestin-related toxicities; in particular, five pts experienced vaginal bleeding (20.8%); four pts experienced weight gain (16.7%); and thromboembolic events, worsening of hypertension, skin rashes, and hyperglycemia were registered in one patient each (4.2%). This led to the discontinuation of megestrol acetate in four pts (16.7%). EDP-M-related toxicities were similar in both groups. No differences in PFS and OS curves were observed; the CBR was 75.0% and 60.4%, respectively. (4) Conclusions: The association of EDP-M + megestrol acetate in ACC pts with a low PS is feasible and well tolerated; its efficacy appeared to be non-inferior to EDP-M administered to pts with a good PS.
TCF12 Activates TGFB2 Expression to Promote the Malignant Progression of Melanoma
Authors: Tian Youjia , Zhou Jiang , Chai Xinxin , Ping Zejun , Zhao Yurong , Xu Xin , Luo Chi , Sheng Jinghao
Published: September 2023

As one of the most common malignant tumors, melanoma is a serious threat to human health. More than half of melanoma patients have a BRAF mutation, and 90% of them have a BRAF(V600E) mutation. There is a targeted therapy for patients using a BRAF(V600E) inhibitor. However, no response to treatment is generally inevitable due to the heterogeneity of melanoma. Coupled with its high metastatic character, melanoma ultimately leads to poor overall survival. This study aimed to explore the possible mechanisms of melanoma metastasis and identify a more effective method for the treatment of melanoma. In this paper, we report that TCF12 expression is higher in melanoma, especially in metastatic tumors, through analyzing data from TCGA. Then, cell proliferation, colony formation, and transwell assays show that the upregulated expression of TCF12 can promote proliferation and metastasis of melanoma cells in vitro. The same result is confirmed in the subcutaneous tumor formation assay. Moreover, TGFB2 is identified as a direct downstream target of TCF12 by RNA-seq, qPCR, immunoblotting, ChIP, and a dual luciferase reporting assay. Interestingly, depletion of TCF12 can sensitize melanoma to BRAF inhibition both in vitro and in vivo. Overall, our results demonstrate that TCF12 promotes melanoma progression and can be a potential tumor therapeutic target.
Associations of Head and Neck Cancer with Hepatitis B Virus and Hepatitis C Virus Infection
Authors: Hung Shih-Han , Yang Tzong-Hann , Cheng Yen-Fu , Chen Chin-Shyan , Lin Herng-Ching
Published: September 2023

This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. We included 5603 patients who had received a diagnosis of HNC as cases and 16,809 propensity score matching controls. We employed multivariate logistic regression models to evaluate the association of HNC with HBV and HCV infection after taking sociodemographic characteristics and diabetes, hypertension, hyperlipidemia, HPV infection, tobacco use disorder, and alcohol abuse/alcohol dependence syndrome into considerations. Results show that 7.9% of the total sample had been previously diagnosed with HBV infection, with 9.0% prevalence among cases and 7.6% among controls (p < 0.001). The chi-squared test suggests a significant difference in the prevalence of HCV infection between cases and controls (3.3% vs. 2.7%, p = 0.019). The covariate-adjusted odds ratio (OR) of HBV infection in patients with HNC relative to controls was 1.219 (95% CI = 1.093~1.359). Additionally, the adjusted OR of HCV infection in patients with HNC was 1.221 (95% CI = 1.023~1.457) compared to controls. Furthermore, patients with oropharyngeal cancer were more likely to have HCV infection than controls (adjusted OR = 2.142, 95% CI = 1.171~3.918). Our study provides evidence that suggests a potential association between HBV and HCV infections and the risk of HNC.
Prognostic Role of Circulating Tumor Cells in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Cabazitaxel: A Prospective Biomarker Study
Authors: Koinis Filippos , Zafeiriou Zafeiris , Messaritakis Ippokratis , Katsaounis Panagiotis , Koumarianou Anna , Kontopodis Emmanouil , Chantzara Evangelia , Aidarinis Chrissovalantis , Lazarou Alexandros , Christodoulopoulos George , Emmanouilides Christos , Hatzidaki Dora , Kallergi Galatea , Georgoulias Vassilis , Kotsakis Athanasios
Published: September 2023

Rational: Circulating tumor cells (CTCs) appear to be a promising tool for predicting the clinical outcome and monitoring the response to treatment in patients with solid tumors. The current study assessed the clinical relevance of monitoring CTCs in patients with metastatic castration resistant prostate cancer (mCRPC) treated with cabazitaxel. Patients and Methods: Patients with histologically confirmed mCRPC who were previously treated with a docetaxel-containing regimen and experienced disease progression were enrolled in this multicenter prospective study. CTC counts were enumerated using the CellSearch system at baseline (before cabazitaxel initiation), after one cabazitaxel cycle (post 1st cycle) and at disease progression (PD). Patients were stratified into predetermined CTC-positive and CTC-negative groups. The phenotypic characterization was performed using double immunofluorescence staining with anti-CKs and anti-Ki67, anti-M30 or anti-vimentin antibodies. Results: The median PFS and OS were 4.0 (range, 1.0–17.9) and 14.5 (range, 1.2–33.9) months, respectively. At baseline, 48 out of 57 (84.2%) patients had ≥1 CTCs/7.5 mL of peripheral blood (PB) and 37 (64.9%) had ≥5 CTCs/7.5 mL of PB. After one treatment cycle, 30 (75%) out of the 40 patients with available measurements had ≥1 detectable CTC/7.5 mL of PB and 24 (60%) ≥ 5CTCs/7.5 mL of PB; 12.5% of the patients with detectable CTCs at the baseline sample had no detectable CTCs after one treatment cycle. The detection of ≥5CTCs/7.5 mL of PB at baseline and post-cycle 1 was associated with shorter PFS and OS (p = 0.002), whereas a positive CTC status post-cycle 1 strongly correlated with poorer OS irrespective of the CTC cut-off used. Multivariate analysis revealed that the detection of non-apoptotic (CK+/M30−) CTCs at baseline is an independent predictor of shorter OS (p = 0.005). Conclusions: In patients with mCRPC treated with cabazitaxel, CTC counts both at baseline and after the first cycle retain their prognostic significance, implying that liquid biopsy monitoring might serve as a valuable tool for predicting treatment efficacy and survival outcomes.
Unveiling the Osteogenic Potential of Tetracyclines: A Comparative Study in Human Mesenchymal Stem Cells
Authors: Martin Victor , Bettencourt Ana Francisca , Santos Catarina , Fernandes Maria Helena , Gomes Pedro Sousa
Published: September 2023

Tetracyclines (TCs) are a class of broad-spectrum antibiotics with diverse pharmacotherapeutic properties due to their various functional groups being attached to a common core structure. Beyond their antibacterial activity, TCs trigger pleiotropic effects on eukaryotic cells, including anti-inflammatory and potentially osteogenic capabilities. Consequently, TCs hold promise for repurposing in various clinical applications, including bone-related conditions. This study presents the first comprehensive comparison of the in vitro osteogenic potential of four TCs—tetracycline, doxycycline, minocycline, and sarecycline, within human mesenchymal stem cells. Cultures were characterized for metabolic activity, cell morphology and cytoskeleton organization, osteogenic gene expression, alkaline phosphatase (ALP) activity, and the activation of relevant signaling pathways. TCs stimulated actin remodeling processes, inducing morphological shifts consistent with osteogenic differentiation. Osteogenic gene expression and ALP activity supported the osteoinduction by TCs, demonstrating significant increases in ALP levels and the upregulation of RUNX2, SP7, and SPARC genes. Minocycline and sarecycline exhibited the most potent osteogenic induction, comparable to conventional osteogenic inducers. Signaling pathway analysis revealed that tetracycline and doxycycline activate the Wnt pathway, while minocycline and sarecycline upregulated Hedgehog signaling. Overall, the present findings suggest that TCs promote osteogenic differentiation through distinct pathways, making them promising candidates for targeted therapy in specific bone-related disorders.
Dose-Dependent Shift in Relative Contribution of Homologous Recombination to DNA Repair after Low-LET Ionizing Radiation Exposure: Empirical Evidence and Numerical Simulation
Authors: Belov Oleg , Chigasova Anna , Pustovalova Margarita , Osipov Andrey , Eremin Petr , Vorobyeva Natalia , Osipov Andreyan N.
Published: September 2023

Understanding the relative contributions of different repair pathways to radiation-induced DNA damage responses remains a challenging issue in terms of studying the radiation injury endpoints. The comparative manifestation of homologous recombination (HR) after irradiation with different doses greatly determines the overall effectiveness of recovery in a dividing cell after irradiation, since HR is an error-free mechanism intended to perform the repair of DNA double-strand breaks (DSB) during S/G2 phases of the cell cycle. In this article, we present experimentally observed evidence of dose-dependent shifts in the relative contributions of HR in human fibroblasts after X-ray exposure at doses in the range 20–1000 mGy, which is also supported by quantitative modeling of DNA DSB repair. Our findings indicate that the increase in the radiation dose leads to a dose-dependent decrease in the relative contribution of HR in the entire repair process.
Effects of Di-(2-Ethylhexyl) Phthalate (DEHP) on Gamete Quality Parameters of Male Koi Carp (Cyprinus carpio)
Authors: Bisai Kampan , Kumar Vikash , Roy Arpita , Parida Satya Narayan , Dhar Souvik , Das Basanta Kumar , Behera Bijay Kumar , Pati Manoj Kumar
Published: September 2023

In this study, we evaluated gamete quality parameters of mature male koi carp (Cyprinus carpio) exposed to three different concentrations (1, 10, and 100 µg/L) of di-(2-ethylhexyl) phthalate (DEHP). After 60 days of exposure, there was a significant decrease in the gonadosomatic index (GSI) of males exposed to 10 and 100 µg/L of DEHP. Histological analysis of the testes revealed impaired histoarchitecture, including inflammatory cells, intratubular vacuoles, and swollen seminiferous tubules in treatment groups. Gamete quality parameters like sperm production, motility, spermatocrit, and sperm density values were significantly decreased at the 10 and 100 µg/L concentrations. Biochemical compositions, including glucose, cholesterol, and total protein levels, were significantly changed in the treatment groups. Similarly, the ionic compositions of seminal fluid (Na, K, Ca, and Mg) also varied in the treatment groups. Furthermore, the 11-ketotestosterone levels were decreased, and the 17-β estradiol levels were increased in the DEHP-treated groups. The mRNA expression levels of reproduction-related genes, including Fshr, Lhr, Ar, Erα, and Erβ, were significantly changed in the DEHP-treated males in a dose-dependent manner. In conclusion, the findings of this study confirmed that environmentally relevant exposure to DEHP may contribute to a decline in the gamete quality of male fishes.
Identification of Potential Protein Targets in Extracellular Vesicles Isolated from Chemotherapy-Treated Ovarian Cancer Cells
Authors: Chan Chia-Yi , Ni Yi-Chun , Nguyen Hieu Duc , Wu Yung-Fu , Lee Kuen-Haur
Published: September 2023

Despite the ongoing clinical trials and the introduction of novel treatments over the past few decades, ovarian cancer remains one of the most fatal malignancies in women worldwide. Platinum- and paclitaxel-based chemotherapy is effective in treating the majority of patients with ovarian cancer. However, more than 70% of patients experience recurrence and eventually develop chemoresistance. To improve clinical outcomes in patients with ovarian cancer, novel technologies must be developed for identifying molecular alterations following drug-based treatment of ovarian cancer. Recently, extracellular vesicles (EVs) have gained prominence as the mediators of tumor progression. In this study, we used mass spectrometry to identify the changes in EV protein signatures due to different chemotherapeutic agents used for treating ovarian cancer. By examining these alterations, we identified the specific protein induction patterns of cisplatin alone, paclitaxel alone, and a combination of cisplatin and paclitaxel. Specifically, we found that drug sensitivity was correlated with the expression levels of ANXA5, CD81, and RAB5C in patients receiving cisplatin with paclitaxel. Our findings suggest that chemotherapy-induced changes in EV protein signatures are crucial for the progression of ovarian cancer.
MicroRNAs as Potential Regulators of GSK-3β in Renal Cell Carcinoma
Authors: Murata Masaki , Bilim Vladimir , Shirono Yuko , Kazama Akira , Hiruma Kaede , Tasaki Masayuki , Tomita Yoshihiko
Published: September 2023

The prognosis of patients with advanced renal cell carcinoma (RCC) has improved with newer therapies, including molecular-targeted therapies and immuno-oncology agents. Despite these therapeutic advances, many patients with metastatic disease remain uncured. Inhibition of glycogen synthase kinase-3β (GSK-3β) is a promising new therapeutic strategy for RCC; however, the precise regulatory mechanism has not yet been fully elucidated. MicroRNAs (miRNAs) act as post-translational regulators of target genes, and we investigated the potential regulation of miRNAs on GSK-3β in RCC. We selected nine candidate miRNAs from three databases that could potentially regulate GSK-3β. Among these, hsa-miR-4465 (miR-4465) was downregulated in RCC cell lines and renal cancer tissues. Furthermore, luciferase assays revealed that miR-4465 directly interacted with the 3′ untranslated region of GSK-3β, and Western blot analysis showed that overexpression of miR-4465 significantly decreased GSK-3β protein expression. Functional assays showed that miR-4465 overexpression significantly suppressed cell invasion of A498 and Caki-1 cells; however, cell proliferation and migration were suppressed only in Caki-1 and A498 cells, respectively, with no effect on cell cycle and apoptosis. In conclusion, miR-4465 regulates GSK-3β expression but does not consistently affect RCC cell function as a single molecule. Further comprehensive investigation of regulatory networks is required in this field.
Multi-Criteria Risk Analysis of Ultra-High Performance Concrete Application in Structures
Authors: Tajasosi Sama , Saradar Ashkan , Barandoust Jalil , Mohtasham Moein Mohammad , Zeinali Reza , Karakouzian Moses
Published: September 2023

In developing countries, ultra-high-performance concrete (UHPC) has not garnered sufficient attention, and its potential industrial applications remain largely unexplored and underdeveloped. The purpose of this paper is to assess the risk associated with integrating UHPC technology into the construction industry, focusing on economic, technical, and environmental facets, as highlighted by global research endeavors in this domain. In this study, a risk model is validated by analyzing diverse UHPC mix proportions from various studies and assessing the associated risk indices concerning constituent materials. The findings demonstrate that incorporating UHPC as a more robust alternative to earlier generations is plausible when considering multiple perspectives within the concrete industry. The preeminence of compressive strength and the significance of service life as a pivotal cost factor during the maintenance period, coupled with comprehensive risk indices, underscore the excellence of UHPC. Comparing UHPC with high-performance concrete (HPC) and normal concrete (NC), it becomes evident that UHPC exerts a notably lower adverse impact on the ecosystem. Additionally, UHPC proves to be a more economically viable option, warranting the replacement of existing technologies.
A Comparison of Cellulose Nanocrystals and Nanofibers as Reinforcements to Amylose-Based Composite Bioplastics
Authors: Faisal Marwa , Žmirić Marija , Kim Ngoc , Bruun Sander , Mariniello Loredana , Famiglietti Michela , Bordallo Heloisa , Kirkensgaard Jacob , Jørgensen Bodil , Ulvskov Peter , Hebelstrup Kim , Blennow Andreas
Published: September 2023

Starch-based bioplastics offer a promising alternative to conventional plastics. However, they exhibit certain limitations, notably in terms of mechanical strength and barrier properties. These challenges could potentially be addressed through the incorporation of nanocellulose as a reinforcing agent. In this study, we fabricated bioplastic films using a casting and blending approach, employing highly linear pure amylose (AM) in combination with cellulose nanofibers (CNF) or cellulose nanocrystals (CNC) at various ratios. This allowed for a direct comparison of CNF and CNC functionality within the AM matrix. We systematically assessed mechanical properties and water barrier characteristics, encompassing parameters such as water permeability, moisture content, swelling, solubility, crystallinity, thermal stability, transmittance, and opacity. Additionally, we investigated water vapor and oxygen permeability. Furthermore, we delved into distinctions between CNC and CNF biocomposites. Incorporation of either type of nanocellulose yielded enhancements in film properties, with CNF exerting a more pronounced positive influence compared to CNC. Particularly noteworthy were the mechanical properties, wherein CNF composite films demonstrated markedly higher tensile strength and Young’s modulus compared to their CNC counterparts. For instance, the inclusion of 1% CNF led to a substantial increase in AM tensile strength from 66.1 MPa to 144.8 MPa. Conversely, water vapor permeability exhibited a converse behavior, as the addition of 1% CNF resulted in a significant reduction of water barrier properties from 8.7 to 1.32 g mm m−2 24 h−1kPa−1. Intriguingly, CNC films displayed greater elongation at the point of rupture in comparison to CNF films. This can be attributed to the larger surface area of the CNC and the favorable interfacial interaction between AM and CNC. Notably, the introduction of nanocellulose led to reduced film opacity and improved thermal stability. In summary, nanocellulose interacted synergistically with the AM matrix, establishing a robust hydrogen-bonded network that greatly enhanced the performance of the biocomposite films.
Antibacterial Effect of Combinations of Salvia officinalis and Glycyrrhiza glabra Hydroalcoholic Extracts against Enterococcus spp.
Authors: Santos Thaís da Silva Alves , Meccatti Vanessa Marques , Pereira Thaís Cristine , Marcucci Maria Cristina , Hasna Amjad Abu , Valera Marcia Carneiro , de Oliveira Luciane Dias , Carvalho Cláudio Antonio Talge
Published: September 2023

Enterococcus spp. are a common culprit behind the failure of endodontic treatments, primarily due to their notorious resistance to antimicrobial agents. Considering this challenge, this study was conducted to assess the antimicrobial efficacy of a unique blend of hydroalcoholic extracts sourced from Salvia officinalis and Glycyrrhiza glabra against biofilms formed by Enterococcus faecalis and Enterococcus faecium. The chemical composition of these plant extracts was rigorously characterized, with primary compound quantification achieved through high-performance liquid chromatography (HPLC-DAD) analysis. Additionally, this study determined the minimal bactericidal concentrations of these extracts and evaluated their potential to combat biofilms by quantifying colony-forming units per milliliter (CFU/mL). The findings reveal that the simultaneous application of both extracts yielded additive and synergistic effects against E. faecalis and E. faecium, including both ATCC and clinical strains. Impressively, after a 24 h exposure, these extract combinations demonstrated efficacy comparable to that of a 0.12% chlorhexidine solution, establishing a statistically significant difference from the negative control group. Consequently, the concurrent use of these extracts emerges as a promising alternative antimicrobial strategy for addressing Enterococcus spp. in endodontic treatments, holding substantial potential for clinical applications in this context.
Functionalization of Fabrics with Graphene-Based Coatings: Mechanisms, Approaches, and Functions
Authors: Liu Yang , Fei Bin , Xin John H.
Published: September 2023

Due to their unique surface-active functionalities, graphene and its derivatives, i.e., graphene oxide (GO) and reduced graphene oxide (rGO), have received enormous research attention in recent decades. One of the most intriguing research hot spots is the integration of GO and rGO coatings on textiles through dyeing methods, e.g., dip-pad-dry. In general, the GO sheets can quickly diffuse into the fabric matrix and deposit onto the surface of the fibers through hydrogen bonding. The GO sheets can be conformally coated on the fiber surface, forming strong adhesion as a result of the high flakiness ratio, mechanical strength, and deformability. Moreover, multiple functions with application significance, e.g., anti-bacteria, UV protection, conductivity, and wetting control, can be achieved on the GO and rGO-coated fabrics as a result of the intrinsic chemical, physical, electronic, and amphiphilic properties of GO and rGO. On the other hand, extrinsic functions, including self-cleaning, self-healing, directional water transport, and oil/water separation, can be achieved for the GO and rGO coatings by the integration of other functional materials. Therefore, multi-scale, multifunctional, smart fabrics with programmable functions and functional synergy can be achieved by the design and preparation of the hybrid GO and rGO coatings, while advanced applications, e.g., healthcare clothing, E-textiles, anti-fouling ultrafiltration membranes, can be realized. In this review, we aim to provide an in-depth overview of the existing methods for functionalizing fabrics with graphene-based coatings while the corresponding functional performance, underlying mechanisms and applications are highlighted and discussed, which may provide useful insights for the design and fabrication of functional textiles and fabrics for different applications.
Research Status and Development Trend of Piezoelectric Accelerometer
Authors: Wu Tianqiong , You Di , Gao Huayun , Lian Pinghua , Ma Weigang , Zhou Xinyi , Wang Chuanmin , Luo Jianghai , Zhang Haibo , Tan Hua
Published: September 2023

Piezoelectric accelerometers have been widely used because of their large range, simple structure, stable performance, and other advantages. With the improvement of science and technology, the application field is expanding, but there are still some problems in high-temperature environments and low-frequency vibration conditions. Under high-temperature environments, the piezoelectric material will undergo depolarization or resistance change, resulting in sensor failure. Aerospace instruments, water conservancy platforms, and other fields require high-precision instruments with vibration amplitudes of the order of a few microns in the range of 0.01–1 Hz, which require low-frequency and ultra-low-frequency sensors for the measurements. Therefore, how to increase the operating temperature and reduce the noise of piezoelectric accelerometers has become a problem that needs to be solved. This paper reviews the structure, principle, application range, and material selection of piezoelectric components of different types of piezoelectric accelerometers and summarizes the current problems and future research priorities.
Exploring the CAM18 Crystal as a Potential Reference Material for U–Pb Analysis of Zircon
Authors: Li Wurui , Xu Bo , Miao Zhuang , Zhao Zheyi , Liu Hangyu
Published: September 2023

In the process of in situ zircon U–Pb dating, it is an effective means to overcome the matrix effect by using a matrix-matched external reference material. However, the limited number of available zircon reference materials still makes it difficult to meet the research needs. In this paper, we performed a preliminary analysis of the gemological characteristics, trace elements and U–Pb ages of natural zircon CAM18 to assess its suitability as a reference material for laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) U–Pb dating. This tawny, gem-quality zircon has no visible inclusions and weighs approximately 0.55 g. Its density, full width at half maximum (FWHM) of the Raman peak and alpha flux (Dα) indicate that the sample has suffered mild-to-moderate radiation damage without any thermal treatment. The LA-ICP-MS U–Pb dating results reveal that the trace elements content and U–Pb ages of the sample are fairly homogeneous at the 50 μm scale, and there is no obvious loss of radiogenic Pb. The 206Pb/238U age (571.0 ± 3.0 Ma, 2s) and 207Pb/235U age (573.4 ± 6.0 Ma, 2s) are consistent within the analytical uncertainty, and the calculated concordia age is 571.4 ± 1.4 Ma (2s, n = 20). The variation in the 206Pb/238U ages is small, with a measurement repeatability of 0.46% (RSD), which is within the uncertainty of the age accuracy obtained by LA-ICP-MS. The oscillatory zoning, Th/U ratio (0.2) and chondrite-normalized rare-earth element (REE) pattern imply a magmatic origin of zircon CAM18. The Ti-in-zircon temperature ranges from 714 to 742 °C, and the oxygen fugacity ranges from ΔFMQ−2.87 to ΔFMQ−3.17, suggesting that it is crystallized in a reducing environment. All the results show that zircon CAM18 may has great potential in LA-ICP-MS U–Pb dating.
Epidemiology, Risk Factors for Gastric Cancer and Surveillance of Premalignant Gastric Lesions: A Prospective Cohort Study of Central Saudi Arabia
Authors: Zacharakis Georgios , Almasoud Abdulaziz , Arahmane Omar , Alzahrani Jamaan , Al-Ghamdi Sameer
Published: September 2023

(1) Background: Saudi Arabia (SA) is a country with a low incidence of gastric cancer (GC). In this study, we sought to assess the epidemiology of GC, its clinicopathological profiles, and its association with risk factors as well as to identify premalignant gastric lesions (PGL) and examine neoplastic progression. (2) Methods: This five-year prospective study screened for GC and PGL in asymptomatic Saudi patients, aged 45–75 years (n = 35,640) and living in Al Kharj, Riyadh province in central SA. Those who were positive in a high-sensitivity guaiac fecal occult blood test (HSgFOBT+) and had negative results in colonoscopy offered to undergo upper GI endoscopy (n = 1242). Factors associated with GC were examined. (3) Results: The five-year participation rate was 87% (1080/1242). The incidence rate of GC was 26.9 new cases per 100,000 population per year (9.6 new cases per year/total population at risk—35,640), and it was 8.9 cases per 1000 persons per year among the 1080 subjects with HSgFOBT+ and negative colonoscopy results. The five-year mortality rate was 67% among patients with GC (n = 48), 3.0% among participants in the gastric screening program (n = 1080) and 0.09% among the original population participating in the colorectal screening program (n = 35,640). Intestinal-type adenocarcinoma was the most frequent type (77%), with the tumor most commonly located in the antrum (41%). Overall, 334 participants had PGL, and seven of them (2.1%) showed neoplastic progression to GC during the follow-up. Factors associated with GC were age, Helicobacter pylori (HP) infection, obesity (body mass index BMI > 30), smoking, a diet of salty preserved foods, low income and a family history of GC. (4) Conclusions: The incidence of GC is low in central SA, but screening for PGL and GC among patients with HSgFOBT+ and negative colonoscopy may prevent or result in the early treatment of GC. HP eradication, normal body weight, not smoking and adhering to a healthy diet can reduce the risk of GC. The resulting data provide important input for the improvement of national guidelines.
Reduced QED with Few Planes and Fermion Gap Generation
Authors: Gorbar Eduard V. , Gusynin Valery P. , Parymuda Maxim R.
Published: September 2023

The formalism of reduced quantum electrodynamics is generalized to the case of heterostructures composed of a few atomically thick layers, and the corresponding effective (2+1)-dimensional gauge theory is formulated. This dimensionally reduced theory describes charged fermions confined to N planes and contains N vector fields with Maxwell’s action modified by non-local form factors whose explicit form is determined. Taking into account the polarization function, the explicit formulae for the screened electromagnetic interaction are presented in the case of two and three layers. For a heterostructure with two atomically thick layers and charged fermions described by the massless Dirac equation, the dynamical gap generation of the excitonic type is studied. It is found that additional screening due to the second layer increases the value of the critical coupling constant for the gap generation compared to that in graphene.
Issues, Challenges, and Future Perspectives of Perovskites for Energy Conversion Applications
Authors: Diouf Boucar , Muley Aarti , Pode Ramchandra
Published: September 2023

Perovskite solar cells are an emerging technology that exploits the self-assembly and highly tunable bandgap properties of perovskite materials. Because of their low manufacturing cost, thin films of perovskites have attracted enormous interest and witnessed great progress. The power conversion efficiency of these devices has improved from 3.8% to 25.8%, which is a significant step forward. The formulation of innovative materials with the proper replacement of lead in perovskites is essential to reduce lead toxicity. Here, we examine the difficulties encountered in the commercialization of perovskite devices, such as material and structural stability, device stability under high temperature and humidity conditions, lifetime, and manufacturing cost. This review addresses issues such as device engineering, performance stability against the harsh environment, cost-effectiveness, recombination, optical, and resistance losses, large-area solar cell module issues, material cost analysis, module cost reduction strategy, and environmental concerns, which are important for the widespread acceptance of perovskite-based solar devices. The applications and market growth prospects of perovskite cells are also studied. In summary, we believe there is a great opportunity to research high-performance, long-lived perovskites and cells for energy applications.
A Three-Phase Synchronization Algorithm Based on a Modified DSOGI with Adjustable Re-Filtering
Authors: Herrejón-Pintor Gilberto A. , Melgoza-Vázquez Enrique , Monroy-Morales José Luis
Published: September 2023

The precise calculation of phase angle, voltage magnitude and frequency is crucial for the effective control of power electronic inverters connected to an electrical power system. The phase-locked loop (PLL) is a commonly employed method for measuring these variables. Nevertheless, the reliability of this measurement is influenced by transient events in the electrical power system and varies depending on the nature of the event and the specific design of the PLL. Notably, PLLs utilizing the double second-order generalized integrator are widely adopted for power converter synchronization purposes. This article proposes a three-phase PLL, which is based on the single-phase version previously reported by the authors. The proposed PLL, based on an alternative integrator approach, allows a fine adjustment of the tolerance to disturbances in the input voltage thanks to a second feedback gain in its pre-filter. It is reasonable to anticipate that the three-phase PLL will exhibit similar strengths to the single-phase version; however, in the three-phase case, an additional integrator is involved in pre-filtering the quadrature signals, and the double integrator is not employed as the quadrature signal generator. The performance of the proposed PLL is assessed by comparing it to other PLLs based on the second-order integrator, using a processor-in-the-loop approach.
Static and Dynamic Electrical Models of Proton Exchange Membrane Electrolysers: A Comprehensive Review
Authors: Marefatjouikilevaee Haniyeh , Auger Francois , Olivier Jean-Christophe
Published: September 2023

Proton Exchange Membrane (PEM) water electrolysers have gained attention as efficient and sustainable hydrogen production devices. Understanding their electrical behavior is crucial for optimizing their performance and control strategies. This comprehensive review analyzes both the static and dynamic electrical models, emphasizing the often-neglected dynamic models. Static models reveal steady-state behavior, offering insights into voltage-current characteristics, polarization phenomena, and overall efficiency. On the other hand, dynamic models capture transient responses, enabling an analysis of time-dependent performance and system reactions to input variations, such as flow rate, temperature, pressure, and electrical potential. The review also addresses overlooked diffusion phenomena, crucial for accurate mass transport dynamics and enhancing dynamic model accuracy. Furthermore, the article highlights challenges and research possibilities in electrical modeling, offering insight into future research subjects.
Impact Analysis of Metallization Design and Recombination Losses on Performance of Crystalline Silicon Solar Cells
Authors: Amin Nowshad , Santhiran Sathiswary , Kassim Nabilah Mat , Alkahtani Ammar Ahmed , Islam Mohammad Aminul , Mohd Yusof Mohd Yusrizal
Published: September 2023

Using Griddler software, this study aims to select the optimal metallization design by analyzing the impact of the number and sizes of busbars and fingers on a solar cell’s performance. There is interest in the PV industry to reduce the finger size toward 25 μm in upcoming years. It is shown that an increase in the number and size of busbars and fingers causes an increase in the fill factor; however, with regards to the cell’s efficiency, the shading factor should be considered in addition to the size and number of metal contacts. The results of this study indicate that solar cells’ efficiency could be increased by 0.33–0.84% when using five busbars and a finger width of 35 μm. Moreover, this increase is achieved by reducing the emitter resistance to less than 60 ohm/sq and considering a recombination rate of about 165 fA/cm2.
Performance Simulation Model of a Radiation-Enhanced Thermal Diode Tank-Assisted Refrigeration and Air-Conditioning (RTDT-RAC) System: A Novel Cooling System
Authors: Wang Mingzhen , Hu Eric , Chen Lei
Published: September 2023

This paper presents a novel technology to improve the energy efficiency of refrigeration and air-conditioning (RAC) systems by applying a condenser cooling approach. The approach is based on the integration of an innovative radiation-enhanced thermal diode tank (RTDT) with a RAC system. The thermal diode tank (TDT), consisting of heat pipes and an insulated water tank, is a passive device to generate cooling water at a minimum night ambient temperature. When the radiation-enhanced heat pipe (RHP) is equipped with the TDT, it becomes an RTDT, which could theoretically lower the water temperature below the ambient temperature. In this study, a radiation-enhanced thermal diode tank (RTDT) is proposed to supply cooling water to the RAC system. Simulation models for the proposed RTDT-assisted RAC (RTDT-RAC) system are developed in order to investigate the impacts of the tank size to cooling capacity (TS/Qc) ratio, day/night ambient temperature fluctuations on the system’s coefficient of performance (COP) and the energy saving percentage (ESP). The results show that a greater day/night ambient temperature difference and a larger TS/Qc value can both enhance the COP and ESP of the RTDT-RAC system. The optimal and threshold TS/Qc values were 1 m3/kW and 0.18 m3/kW, respectively. These findings demonstrate the potential of the RTDT-RAC system to achieve significant energy savings and provide valuable insights for the design and optimization of an RTDT-RAC system.
The Impact of COVID-19 on the Energy Sector and the Role of AI: An Analytical Review on Pre- to Post-Pandemic Perspectives
Authors: Arsad Siti Rosilah , Hasnul Hadi Muhamad Haziq , Mohd Afandi Nayli Aliah , Ker Pin Jern , Tang Shirley Gee Hoon , Mohd Afzal Madihah , Ramanathan Santhi , Chen Chai Phing , Krishnan Prajindra Sankar , Tiong Sieh Kiong
Published: September 2023

The COVID-19 pandemic has disrupted global energy markets and caused significant socio-economic impacts worldwide, including the energy sector due to lockdowns and restricted economic activity. This paper presents a comprehensive and analytical review of the impact of COVID-19 on the energy sector and explores the potential role of artificial intelligence (AI) in mitigating its effects. This review examines the changes in energy demand patterns during the pre-, mid-, and post-pandemic periods, analyzing their implications for the energy industries, including policymaking, communication, digital technology, energy conversion, the environment, energy markets, and power systems. Additionally, we explore how AI can enhance energy efficiency, optimize energy use, and reduce energy wastage. The potential of AI in developing sustainable energy systems is discussed, along with the challenges it poses in the energy sector’s response to the pandemic. The recommendations for AI applications in the energy sector for the transition to a more sustainable energy future, with examples drawn from previous successful studies, are outlined. Information corroborated in this review is expected to provide important guidelines for crafting future research areas and directions in preparing the energy sector for any unforeseen circumstances or pandemic-like situations.
Energy Assessment of Different Powertrain Options for Heavy-Duty Vehicles and Energy Implications of Autonomous Driving
Authors: Sigle Sebastian , Hahn Robert
Published: September 2023

Heavy-duty vehicles (HDVs) are responsible for a significant amount of CO2 emissions in the transport sector. The share of these vehicles is still increasing in the European Union (EU); nevertheless, rigorous CO2 emission reduction schemes will apply in the near future. Different measures to decrease CO2 emissions are being already discussed, e.g., the electrification of the powertrain. Additionally, the impact of autonomous driving on energy consumption is being investigated. The most common types are fuel cell vehicles (FCEVs) and battery-only vehicles (BEVs). It is still unclear which type of powertrain will prevail in the future. Therefore, we developed a method to compare different powertrain options based on different scenarios in terms of primary energy consumption, CO2 emissions, and fuel costs. We compared the results with the internal combustion engine vehicle (ICEV). The model includes a model for the climatization of the driver’s cabin, which we used to investigate the impact of autonomous driving on energy consumption. It became clear that certain powertrains offer advantages for certain applications and that sensitivities exist with regard to primary energy and CO2 emissions. Overall, it became clear that electrified powertrains could reduce the CO2 emissions and the primary energy consumption of HDVs. Moreover, autonomous vehicles can save energy in most cases.
Exploring the Properties of the Torrefaction Process and Its Prospective in Treating Lignocellulosic Material
Authors: Ivanovski Maja , Petrovič Aleksandra , Goričanec Darko , Urbancl Danijela , Simonič Marjana
Published: September 2023

The main objective of this review is to present the latest research results regarding the importance of the torrefaction process for different biomass materials in the last 12-year period. Despite the fact that the potential of renewable energy sources has been analyzed, research regarding that of energy derived from waste biomass still remains in the infancy state. Torrefaction is known to be one of the most effective methods for enhancing the energy efficiency of biomass. Among different types of torrefactions, the focus in this study is mostly on dry torrefaction. The influential factors, like temperature and residence time, and physico-chemical properties of torrefied products, and the prospective of torrefaction due to its reduced impact on environment, are discussed in-depth. This review provides valuable insights into the torrefaction process, which is conducive to upgrading biomass for achieving net zero carbon emissions, as it has been stated in several works that torrefied biomass can be used instead of coal.
Reaction Temperature Manipulation as a Process Intensification Approach for CO2 Absorption
Authors: Gabitto Jorge Federico , Tsouris Costas
Published: September 2023

Reactor temperature manipulation to increase product yields of chemical reactions is a known technique used in many industrial processes. In the case of exothermic chemical reactions, the well-known Le Chatelier’s principle predicts that a decrease in temperature will displace the chemical reaction toward the formation of products by increasing the value of the equilibrium constant. The reverse is true for endothermic reactions. Reactor temperature manipulation in an industrial system, however, affects the values of many variables, including physical properties, transport parameters, reaction kinetic parameters, etc. In the case of reactive absorption, some variables change with increasing temperatures due to solute absorption, while others change in such a way that the solute absorption rate decreases. For example, temperature drop increases product formation for exothermic reactions but reduces the value of transport parameters, leading to decreasing interfacial concentrations and absorption rates. Therefore, temperature manipulation strategies must be designed carefully to achieve the process goals. In this work, we theoretically study the use of temperature as a tool to increase CO2 absorption by solvents in a semi-batch reactor. A computer code has been developed and validated using reported experimental data. Calculated results demonstrate an increase in absorbed CO2 of more than 28% with respect to the highest temperature used. Despite high agitation and high gas flow rate, the system is mass transfer controlled at short times, becoming kinetically controlled as time increases. An operating strategy to decrease cooling energy costs is also proposed. This study reveals that reactor temperature manipulation can be an effective process to improve CO2 absorption by solvents in two-phase semi-batch reactors.
Techno-Economic and Environmental Evaluation of a Solar Energy System on a Ro-Ro Vessel for Sustainability
Authors: Serris Michail , Petrou Paraskevi , Iakovidis Isidoros , Dimitrellou Sotiria
Published: September 2023

The increased use of fossil fuels in transportation is considered a major cause of environmental pollution and climate change on a global scale. In international shipping, regulations and strict measures have been introduced by the International Maritime Organization to achieve the goal of a 40% reduction in greenhouse gas (GHG) emissions by 2030, with the envisage to reach net-zero GHG emissions close to 2050. Renewable energy sources, such as solar photovoltaic (PV) systems, can be implemented on new-build or existing marine vessels as an effective alternative source for auxiliary power generation, reducing the dependency on fossil fuels and contributing to decarbonization. In the present paper, a sustainable retrofit design using PV panels on an existing Ro-Ro vessel is analyzed for its feasibility. The proposed system is used for energy production during ship cargo operations and takes advantage of the large space area on the upper deck and its continuous exposure to sunlight during its voyage. To investigate the effectiveness of the PV system as an alternative to fossil fuel consumption, an environmental and economic evaluation is performed. According to the results obtained, the solar PV system can provide approximately 88% of the required energy annually for lighting during ship cargo operations, with the corresponding fuel savings and emission reductions, making the investment economically feasible, with a high potential to contribute to environmental sustainability.