bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebrolysin dose-dependently improves neurological outcome in rats after acute stroke: A prospective, randomized, blinded, and placebo-controlled study
Authors: Zhang Li , Chopp Michael , Lu Mei , Zhang Talan , Winter Stefan , Doppler Edith , Meier Dieter , Chao Li , Eapen Anita , Pabla Pardeep , Gang Zhang Zheng
Published: January 2016

Background

Cerebrolysin is a mixture of neuropeptides and free amino acids that is clinically used for the treatment of stroke. To further standardize treatment schemes, we assessed the dose response of Cerebrolysin on sensorimotor outcome in a rat model of ischemic stroke.

Methods

This study was a prospective, blinded, placebo-controlled, preclinical experiment. Male and female Wistar rats, subjected to embolic middle cerebral artery occlusion, were randomly treated with Cerebrolysin doses of 0.8, 2.5, 5.0, 7.5 ml/kg or placebo, 4 h after middle cerebral artery occlusion for a total of 10 consecutive days.

Results

The primary outcome was neurologic improvement at day 28, lesion volume, mortality, and animal weight were secondary and safety outcomes, respectively. There was a significant ( p < 0.001) dose effect of Cerebrolysin on neurological outcome. Cerebrolysin at a dose of ≥ 2.5 ml/kg significantly ( p < 0.001) improved neurological outcome (Mean Estimate (95% CL): 0.8 ml/kg: 6.2 (–6.0/18.4), 2.5 ml/kg: −28.9 (−41.6/−16.2), 5.0 ml/kg: −33.4 (−45.0/−21.7), 7.5 ml/kg: −36.3 (−48.2/−24.4). Higher doses (≥2.5 ml/kg) resulted in better recovery; however, differences between effective doses were not significant. Treatment with 5 ml/kg reduced lesion volume ( p = 0.016). No treatment gender interactions were found and there were no differences in death or weight loss.

Conclusion

Collectively, these data on Cerebrolysin efficacy demonstrate the feasibility of a preclinical study setup following a randomized, placebo-controlled, and blinded design with a clinical relevant treatment scheme. Cerebrolysin at doses of ≥ 2.5 ml/kg improved functional outcome and at a dose of 5 ml/kg reduced infarct volume.
Gout: optimizing treatment to achieve a disease cure
Authors: Bernal José Antonio , Quilis Neus , Andrés Mariano , Sivera Francisca , Pascual Eliseo
Published: January 2016

Gout is one of the most common inflammatory arthritides. The disease is due to the deposition of monosodium urate crystals. These deposits are reversible with proper treatment, suggesting that gout is a curable disease. The main aim in gout is to lower serum uric acid levels to a pre-established target; there are different urate-lowering drugs (xanthine oxidase inhibitors, uricosurics and uricases) through which this can be achieved. Proper treatment of gout also involves correct management of acute flares and their prevention. To ensure treatment adherence it is necessary to explain to the patient what the objectives are.
The Construction of an Inventory of Responses to Positive Affective States
Authors: Wright Kim , Armstrong Tamsin
Published: January 2016

We report the construction of the Inventory of Responses to Positive Affective States (IRPAS), a trait, self-report measure of response to positive affect. The IRPAS differs from existing measures by addressing a broad set of responses to positive affect, including but not limited to affect regulation strategies, and by considering relevance to a range of positive affective states. In Study 1, qualitative interviews were conducted with 21 individuals to inform item content. In Study 2, factor analysis of the final item set was conducted using data from 540 individuals. Study 3 investigated convergent and divergent validity and test–retest reliability of the resulting 59-item IRPAS. The IRPAS was found to be reliable and valid, and to make a unique contribution to the literature on response to positive mood. Further validation studies should be conducted; potential applications include exploration of positive affect functioning in both clinical and non-clinical populations.
Some generalizations of Darbo’s theorem and applications to fractional integral equations
Authors: Jleli Mohamed , Karapinar Erdal , O’Regan Donal , Samet Bessem
Published: January 2016

In this paper, some generalizations of Darbo’s fixed point theorem are presented. An existence result for a class of fractional integral equations is given as an application of the obtained results.
High quality permanent draft genome sequence of Phaseolibacter flectens ATCC 12775T, a plant pathogen of French bean pods
Authors: Aizenberg-Gershtein Yana , Izhaki Ido , Lapidus Alla , Copeland Alex , Reddy TBK , Huntemann Marcel , Pillay Manoj , Markowitz Victor , Göker Markus , Woyke Tanja , Klenk Hans-Peter , Kyrpides Nikos C. , Halpern Malka
Published: January 2016

Phaseolibacter flectens strain ATCC 12775T (Halpern et al., Int J Syst Evol Microbiol 63:268–273, 2013) is a Gram-negative, rod shaped, motile, aerobic, chemoorganotroph bacterium. Ph. flectens is as a plant-pathogenic bacterium on pods of French bean and was first identified by Johnson (1956) as Pseudomonas flectens. After its phylogenetic position was reexamined, Pseudomonas flectens was transferred to the family Enterobacteriaceae as Phaseolibacter flectens gen. nov., comb. nov. Here we describe the features of this organism, together with the draft genome sequence and annotation. The DNA GC content is 44.34 mol%. The chromosome length is 2,748,442 bp. It encodes 2,437 proteins and 89 RNA genes. Ph. flectens genome is part of the Genomic Encyclopedia of Type Strains, Phase I: the one thousand microbial genomes study.
Effect of electrode shape on grounding resistances — Part 2: Experimental results and cryospheric monitoring
Authors: Tomaškovičová Soňa , Ingeman-Nielsen Thomas , Christiansen Anders V. , Brandt Inooraq , Dahlin Torleif , Elberling Bo
Published: January 2016

Although electric resistivity tomography (ERT) is now regarded as a standard tool in permafrost monitoring, high grounding resistances continue to limit the acquisition of time series over complete freeze-thaw cycles. In an attempt to alleviate the grounding resistance problem, we have tested three electrode designs featuring increasing sizes and surface area, in the laboratory and at three different field sites in Greenland. Grounding resistance measurements showed that changing the electrode shape (using plates instead of rods) reduced the grounding resistances at all sites by 28%–69% during unfrozen and frozen ground conditions. Using meshes instead of plates (the same rectangular shape and a larger effective surface area) further improved the grounding resistances by 29%–37% in winter. Replacement of rod electrodes of one entire permanent permafrost monitoring array by meshes resulted in an immediate reduction of the average grounding resistance by 73% from [Formula: see text] to [Formula: see text] (unfrozen conditions); in addition, the length of the acquisition period during the winter season was markedly prolonged. Grounding resistance time series from the three ERT monitoring stations in Greenland showed that the electrodes were rarely perfectly grounded and that grounding resistances exceeding [Formula: see text] may occur in severe cases. We concluded that the temperature, electrode shape, and lithology at the sites have a marked impact on electrode performance. Choosing an optimized electrode design may be the deciding factor for successful data acquisition, and should therefore be considered when planning a long-term monitoring project.
ReCAP: Economic Evaluation Alongside a Clinical Trial of Telephone Versus In-Person Genetic Counseling forBRCA1/2Mutations in Geographically Underserved Areas
Authors: Chang Yaojen , Near Aimee M. , Butler Karin M. , Hoeffken Amanda , Edwards Sandra L. , Stroup Antoinette M. , Kohlmann Wendy , Gammon Amanda , Buys Saundra S. , Schwartz Marc D. , Peshkin Beth N. , Kinney Anita Y. , Mandelblatt Jeanne S. , Chang Yaojen , Near Aimee M. , Butler Karin M. , Hoeffken Amanda , Edwards Sandra L. , Stroup Antoinette M. , Kohlmann Wendy , Gammon Amanda , Buys Saundra S. , Schwartz Marc D. , Peshkin Beth N. , Kinney Anita Y. , Mandelblatt Jeanne S.
Published: January 2016

QUESTION ASKED:

Many individuals at risk for BRCA1 or BRCA2 mutations do not have access to trained genetic counselors. This study conducted an economic evaluation alongside a clinical trial of approaches to extending the reach of genetic testing services to geographically underserved populations.

SUMMARY ANSWER:

Telephone genetic counseling was less expensive than in-person services delivered in the community per individual counseled, individual tested, or mutation detected. For example, it cost an average of $120 (range, $80 to $200) per person counseled in the telephone counseling arm compared with $270 (range, $180 to $400) for in-person counseling. One-way sensitivity analyses showed that the average cost per participant remained consistently lower in the telephone counseling arm than in the in-person counseling arm across the range values for each cost parameter and for each study outcome.

METHODS:

Microcosting was used to enumerate resources for counseling delivered at 14 primary care clinics (nine geographically remote, five urban) in Utah. Staff time and travel, space, overhead, patient time costs, and test costs were calculated on the basis of actual intervention use and valued using national data for wage rates, space, and overhead. We calculated the costs per arm for pretest counseling, uptake of BRCA1/BRCA2 testing, per mutation detected, and per completion of post-test genetic counseling at 6 months afterrandomization. Costs and effects were not discounted.

BIAS, CONFOUNDING FACTOR(S), DRAWBACKS:

The findings may not be generalizable to women in other geographically underserved regions in terms of socio-demographic characteristics and mutation risk. Next, we included only costs related to genetic counseling and testing. Counseling and testing may affect other costs, such as those related to increased or decreased short-term use of medical care or long-term health behaviors.

REAL-LIFE IMPLICATIONS:

Telephone counseling is a cost-efficient method to extend the reach of genetic counseling services in geographically remote areas.
Transition of Care for Inpatient Hematology Patients Receiving Chemotherapy: Development of Hospital Discharge Huddle Process and Effects of Implementation
Authors: Warsame Rahma , Kasi Pashtoon M. , Villasboas-Bisneto Jose C. , Gallenberg DeWayne , Wolf Robert , Ward James , Matt-Hensrud Natasha , Grethen Kimberly , Colborn Lisa , Zeldenrust Steven , Lacy Martha Q. , Thompson Carrie A.
Published: January 2016

Developing a systematic approach to hospital discharges can lead to improvements and serve a model for other inpatient wards.
Improving the Safety of Oral Chemotherapy at an Academic Medical Center
Authors: Shah Nirav N. , Casella Erica , Capozzi Donna , McGettigan Suzanne , Gangadhar Tara C. , Schuchter Lynn , Myers Jennifer S.
Published: January 2016

Purpose:

Over the last decade, the use of oral chemotherapy (OC) for the treatment of cancer has dramatically increased. Despite their route of administration, OCs pose many of the same risks as intravenous agents. In this quality improvement project, we sought to examine our current process for the prescription of OC at the Abramson Cancer Center of the University of Pennsylvania and to improve on its safety.

Methods:

A multidisciplinary team that included oncologists, advanced-practice providers, and pharmacists was formed to analyze the current state of our OC practice. Using Lean Six Sigma quality improvement tools, we identified a lack of pharmacist review of the OC prescription as an area for improvement. To address these deficiencies, we used our electronic medical system to route OC orders placed by treating providers to an oncology-specific outpatient pharmacist at the Abramson Cancer Center for review.

Results:

Over 7 months, 63 orders for OC were placed for 45 individual patients. Of the 63 orders, all were reviewed by pharmacists, and, as a result, 22 interventions were made (35%). Types of interventions included dosage adjustment (one of 22), identification of an interacting drug (nine of 22), and recommendations for additional drug monitoring (12 of 22).

Conclusion:

OC poses many of the same risks as intravenous chemotherapy and should be prescribed and reviewed with the same oversight. At our institution, involvement of an oncology-trained pharmacist in the review of OC led to meaningful interventions in one third of the orders.
Curing Metastatic Breast Cancer
Authors: Sledge George W.
Published: January 2016

Metastatic breast cancer is generally considered incurable, and this colors doctor-patient interactions for patients with metastatic disease. Although true for most patients, there appear to be important exceptions, instances where long-term disease-free survival occurs. Although these instances are few in number, they suggest the possibility of cure. How will we move toward cure for a much larger population of patients with metastatic disease? This article outlines a potential research agenda that might move us toward that distant goal.
Surgical Management of Liver Metastases From Colorectal Cancer
Authors: Dhir Mashaal , Sasson Aaron R.
Published: January 2016

Surgical resection remains one of the major curative treatment options available to patients with colorectal liver metastases. Surgery and chemotherapy form the backbone of the treatment in patients with colorectal liver metastases. With more effective chemotherapy regimens being available, the optimal timing and sequencing of treatments are important. A multidisciplinary approach with the involvement of medical oncologists and surgical oncologists from the beginning is crucial. Identification of the clinical and molecular prognostic factors may help personalize the treatment approaches for these patients. This article provides an overview of the surgical management of colorectal liver metastases.
Disappointment in the Archives of Black Freedom
Authors: Rusert Britt
Published: January 2016

This article uses a collection of African American women's friendship albums held at the Library Company of Philadelphia to reflect on scholarly resistance to reading disappointment, and negativity more generally, in the archives of black freedom. Rather than viewing these artifacts as expressions of black women's freedom in antebellum Philadelphia, the author reads them as documents that register the many disappointments of freedom, especially for women. This article also considers how disappointment itself may be a productive approach to the archives of nominal freedom. Despite recent work that has reflected on the melancholic attachments of black studies, as well as a growing interest in Afro-pessimism and the long afterlives of slavery, the spirit and force of these contributions have yet to shape our approach to the archive of black freedom, which is often nothing more than the uncanny double of slavery's archive.
Decreased N-TAF1 expression in X-Linked Dystonia-Parkinsonism patient-specific neural stem cells
Authors: Ito Naoto , Hendriks William T. , Dhakal Jyotsna , Vaine Christine A. , Liu Christina , Shin David , Shin Kyle , Wakabayashi-Ito Noriko , Dy Marisela , Multhaupt-Buell Trisha , Sharma Nutan , Breakefield Xandra O. , Bragg D. Cristopher
Published: January 2016

X-linked Dystonia-Parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models available for studying the disease. The XDP haplotype consists of multiple sequence variations in a region of the X chromosome containing TAF1, a large gene with at least 38 exons, and a Multiple Transcript System, MTS, comprised of five unconventional exons. A previous study identified an XDP-specific insertion of an SVA-type retrotransposon in intron 32 of TAF1, as well as a neural-specific TAF1 isoform, N-TAF1, which showed decreased expression in post-mortem XDP brain, compared to control tissue. Here we generated XDP patient and control fibroblasts and induced pluripotent stem cells (iPSCs) in order to further probe cellular defects associated with this disease. As initial validation of the model, we compared expression of TAF1 and MTS transcripts in XDP vs. control fibroblasts and iPSC-derived neural stem cells (NSCs). Compared to control cells, XDP fibroblasts exhibited decreased expression of TAF1 transcript fragments derived from exons 32-36, a region spanning the SVA insertion site. N-TAF1, which incorporates an alternative exon 34', was not expressed in fibroblasts, but was detectable in iPSC-differentiated NSCs at levels that were approximately 3-fold lower in patient cells than controls. These results support the previous findings that N-TAF1 expression is impaired in XDP, while further indicating that this aberrant transcription may occur in neural cells at relatively early stages of development that precede neurodegeneration.
New Wistar Kyoto and Spontaneously Hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein
Authors: Diaz Ana Isabel Garcia , Moyon Ben , Coan Philip M , Alfazema Neza , Venda Lara , Woollard Kevin , Aitman Tim
Published: January 2016

The Wistar Kyoto rat (WKY) and the Spontaneously Hypertensive Rat (SHR) inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome respectively. Novel transgenic (Tg) strains add research opportunities and increase scientific value to well-established rat models. We have created two novel Tg strains using Sleeping Beauty transposon germline transgenesis, ubiquitously expressing green fluorescent protein (GFP) under the rat elongation factor 1 alpha (rEF1a) promoter on the WKY and SHR genetic backgrounds. The Sleeping Beauty system functioned with high transgenesis efficiency in our hands: 75% of the new rats born after embryo microinjections were transgene positive. By ligation-mediated PCR, we located the genome integration sites, confirming no exonic disruption and defining single or low copy number of the transgenes in the new WKY-GFP and SHR-GFP Tg lines. We report GFP bright expression in embryos, tissues and organs in both lines and show preliminary in vitro and in vivo imaging data that show the utility of the new GFP-expressing lines for adoptive transfer, transplantation and fate mapping studies of CRGN, metabolic syndrome and other traits for which these strains have been extensively studied over the past four decades.
Hic-5 mediates endothelial sprout initiation by regulating a key surface metalloproteinase
Authors: Dave Jui M. , Abbey Colette A. , Duran Camille L. , Seo Heewon , Johnson Gregory A. , Bayless Kayla J.
Published: January 2016

During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. We tested here whether the focal adhesion scaffold protein Hic-5 regulated endothelial sprouting in three-dimensions. Hic-5 silencing reduced endothelial sprouting and lumen formation, and sprouting defects were rescued by the return of Hic-5 expression. Pro-angiogenic factors enhanced co-localization and complex formation between membrane type-1 matrix metalloproteinase (MT1-MMP) and Hic-5, but not paxillin, and the LIM2 and LIM3 domains of Hic-5 were necessary and sufficient for MT1-MMP complex formation. MT1-MMP and Hic-5 complex formation and localization within detergent-resistant membrane fractions were enhanced during endothelial sprouting, and Hic-5 depletion lowered surface levels of MT1-MMP. In addition, we observed that loss of Hic-5 partially reduced MT1-MMP and focal adhesion kinase (FAK) complex formation, suggesting that Hic-5 bridges MT1-MMP and FAK. Finally, Hic-5 LIM2-3 deletion mutants reduced sprout initiation. Hic-5, MT1-MMP, and FAK co-localized in angiogenic vessels during porcine pregnancy, supporting that this complex assembles during angiogenesis in vivo. Collectively, Hic-5 appears to enhance complex formation between MT1-MMP and FAK in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility.
Inhibition of KDM6 activity during murine ES cell differentiation induces DNA damage
Authors: Hofstetter Christine , Kampka Justyna M. , Huppertz Sascha , Weber Heike , Schlosser Andreas , Müller Albrecht M. , Becker Matthias
Published: January 2016

Pluripotent embryonic stem (ES) cells are characterized by their capacity to self-renew indefinitely while maintaining the potential to differentiate into all cell types of an adult organism. Both the undifferentiated and differentiated states are defined by specific gene expression programs that are regulated at the chromatin level. By employing the KDM6-specific GSK-J4 inhibitor and by targeted gene knockout/knockdown (KO/KD), we have analyzed the contribution of the H3K27me2,3-specific demethylases KDM6A and KDM6B to murine ES cell differentiation. We observe that inhibition of the H3K27 demethylase activity induces DNA damage along with activation of the DNA damage response (DDR) and cell death in differentiating but not in undifferentiated ES cells. Laser microirradiation experiments revealed that the H3K27me3 mark but not the KDM6B protein co-localize with γH2AX+ sites of DNA damage in differentiating ES cells. Lack of H3K27me3 attenuates the GSK-J4-induced DDR in differentiating Eed KO ES cells. Collectively our findings indicate that differentiating ES cells depend on KDM6 and that the H3K27me3 demethylase activity is critically involved in DDR and survival of differentiating ES cells.
Development of Highly Active Ir–PNP Catalysts for Hydrogenation of Carbon Dioxide with Organic Bases
Authors: Aoki Wataru , Wattanavinin Natdanai , Kusumoto Shuhei , Nozaki Kyoko
Published: January 2016

Methoxy-substituted PNP–iridium(III) complexes and pyrazine-based PNP–iridium(III) complexes were developed and used to hydrogenate carbon dioxide in the presence of triethanolamine as a base. The methoxy-substituted PNP–hydridodichloridoiridium complex (C-HCl2) showed the highest turnover number, 160000; this is the highest value ever reported with an organic base in an aqueous medium. The reactivities of these complexes, derived from their ligand modification, were further studied. The results were as follows. (i) The pyrazine-based PNP–trihydridoiridium complex undergoes release of dihydrogen to afford dihydridoamido complex, possibly because of easy dearomatization of the pyrazine ring. This process was reversible, i.e., B-H2amido can readily be converted back to B-H3 on exposure to dihydrogen. (ii) The p-methoxy-substituted dihydridochlorido complex showed facile disproportionation of the chloride anion on the iridium center; this is attributed to the electron-donating nature of the methoxypyridine backbone.
Cross-backbone templating; ribodinucleotides made on poly(C)
Authors: Majerfeld Irene , Puthenvedu Deepa , Yarus Michael
Published: January 2016

G5′pp5′G synthesis from pG and chemically activated 2MeImpG is accelerated by the addition of complementary poly(C), but affected only slightly by poly(G) and not at all by poly(U) and poly(A). This suggests that 3′–5′ poly(C) is a template for uncatalyzed synthesis of 5′–5′ GppG, as was poly(U) for AppA synthesis, previously. The reaction occurs at 50 mM mono- and divalent ion concentrations, at moderate temperatures, and near pH 7. The reactive complex at the site of enhanced synthesis of 5′–5′ GppG seems to contain a single pG, a single phosphate-activated nucleotide 2MeImpG, and a single strand of poly(C). Most likely this structure is base-paired, as the poly(C)-enhanced reaction is completely disrupted between 30 and 37°C, whereas slower, untemplated synthesis of GppG accelerates. More specifically, the reactive center acts as would be expected for short, isolated G nucleotide stacks expanded and ordered by added poly(C). For example, poly(C)-mediated GppG production is very nonlinear in overall nucleotide concentration. Uncatalyzed NppN synthesis is now known for two polymers and their complementary free nucleotides. These data suggest that varied, simple, primordial 3′–5′ RNA sequences could express a specific chemical phenotype by encoding synthesis of complementary, reactive, coenzyme-like 5′–5′ ribodinucleotides.
Being in the world
Authors: Houser Nathan
Published: January 2016

This essay addresses a question raised by Helmut Pape: “What logical, semiotical and mental structure does our consciousness have to have in order to establish the proper link between perception, thought and propositional content expressed by indicators?” The answer, it is proposed, is found in Peirce’s Existential Graphs (EG). First, EG is, itself, a model of cognition that provides the formal structure required for such a consciousness. Second, an appropriate semiotical interpretation will give us the requested structure. Third, interpreted as a psychological or perceptual model, EG will represent the links we seek.
CONFIANÇA EM REDES SEGUNDO A TEORIA DA NOVA ECONOMIA INSTITUCIONAL
Authors: Scarton Luciana Maria , Winck César Augustus , Leonardi Alex
Published: January 2016

As organizações buscam reduzir seus custos, sem considerar que esses são divididos em de produção e de transação. No entanto, nos últimos anos, os debates teóricos sobre os custos de transação têm demonstrado relevante importância no contexto da competitividade. Nesse sentido, a Nova Economia Institucional, que traz consigo a Teoria dos Custos de Transação, aborda as estruturas de governança e suas formas de coordenação. Normalmente se classificam as estruturas organizacionais entre mercados e hierarquias, mas, sabe-se que o dinamismo do mercado competitivo considera a forma híbrida como uma terceira de estrutura de governança com um misto de controle e incentivo, onde as Redes ganham destaque. Portanto, tem-se por objetivo trazer uma discussão teórica sobre as relações de confiança em organizações híbridas, no contexto da Nova Economia Institucional e para facilitar a compreensão, elaborou-se um framework para demonstrar a importância da confiança em um ambiente de riscos e incertezas.
COMPETÊNCIAS PARA A DOCÊNCIA ON-LINE: PERCEPÇÃO DE PROFESSORES DE PÓS-GRADUAÇÃO NO ENSINO A DISTÂNCIA
Authors: Gomes Giancarlo , Saragoça Viviane Alexandra Machado , Domingues Maria Jose Carvalho de Souza
Published: January 2016

O objetivo do estudo foi identificar as competências e habilidades necessárias ao docente de Ensino a Distância no processo de ensino e aprendizagem. A pesquisa foi descritiva, de levantamento, com 18 professores/tutores de cursos de pós-graduação lato sensu a distancia. Os resultados apontam que para desempenhar um papel diferenciado na docência on-line, é necessário que o professor adquira e desenvolva um conjunto particular de habilidades e competências. As habilidades de facilitação tiveram maior destaque, e dentre elas pode-se ressaltar: a capacidade de fornecer orientação e apoio on-line para alunos, a capacidade de envolver o aluno no processo de aprendizagem. As habilidades técnicas consideradas essenciais foram: a capacidade de usar e-mail eficazmente, a utilização de fóruns ou quadros de avisos. As habilidades gerenciais receberam menor destaque na pesquisa.
Competências empreendedoras: um estudo com funcionários administrativos de uma empresa do ramo alimentício
Authors: Lizote Suzete Antonieta , Verdinelli Miguel Angel
Published: January 2016

As mudanças no ambiente de negócios fazem comque as organizações necessitem estar prontas para enfrentá-las e o fator humanoé uma das condições mais importante. É necessário contar com pessoascomprometidas, capazes de perceber e buscar oportunidades. Isto implica em tercolaboradores que possuam competências empreendedoras ou que possamdesenvolvê-las e assim contribuir para o desempenho desejado, tanto pessoalcomo organizacional. Este estudo tem como objetivo identificar e avaliar quaiscompetências empreendedoras estão presentes nos colaboradores de uma empresa doramo alimentício localizada em Itajaí, Santa Catarina. As análises de dados foramexploratórias, descritivas e inferenciais, empregando-se técnicas estatísticasunivariadas e multivariadas. Os resultados mostram que as competênciasempreendedoras encontram-se presente nos funcionários, mas elas não sedistribuem homogeneamente, permitindo segregar os respondentes em quatrogrupos. Assim mesmo, as dez competências consideradas não se manifestam emconcordância com o modelo teórico que as agrupa em três conjuntos, o derealização, de planejamento e de poder. Para a amostra, a análise fatorialexploratória permitiu distinguir dois grupos de competências e, a partir deles,as posteriores análises de variância mostraram diferenças ao considerar o grupoem que o empregado está inserido, seu gênero e seu tempo de serviço na organização
Determinantes para a Formação da Cultura Empreendedora: a Experiência do Projeto Desafio SEBRAE.
Authors: Castro Maurício Mendes Boavista de , Souza Sérgio Aquino de , Nascimento João Carlos Hipolito B. , Pinheiro Leonardo Victor de Sá , Bernardes Juliana Reis
Published: January 2016

O presente estudo de caráter descritivo foi operacionalizado por meio de levantamento de dados com os alunos piauienses que participaram do jogo de empresas desafio SEBRAE. Nesse aspecto, o objetivo do presente estudo foi verificar se o jogo de empresas Desafio SEBRAE apresenta influência significativa para que o estudante universitário piauiense obtenha uma visão empreendedora. Considerando que política de aplicação de jogos e simulações nas escolas e instituições formadoras de futuros profissionais de mercado ajuda significativamente à sua formação empreendedora, pôde-se considerar, dentre os achados da pesquisa, que o jogo virtual Desafio SEBRAE cumpre seu papel, seja completando a lacuna não preenchida pelo sistema de Ensino Superior padrão, seja motivando a cultura empreendedora dos alunos através da incursão prática que as simulações de mercado oferecem.Palavras-chave: Jogos de Empresas; Empreendedorismo; Ensino Superior.
Os efeitos do cause-related marketing no comportamento do consumidor
Authors: Silva Renata Céli Moreira da , Motta Paulo Cesar De Mendonca
Published: January 2016

A questão social vem sendo amplamente discutida. É importante que a empresa adote práticas sociais. Um programa a ser estudado é o Cause-Related Marketing – CRM. Nesse contexto, o presente estudo teve o objetivo de contribuir para um melhor entendimento dessa ferramenta, buscando investigar o comportamento dos consumidores frente aos produtos de empresas que praticam o CRM. Foi aplicado um questionário, que foi respondido por 125 consumidores. No questionário, foi apresentada uma situação hipotética de compra de pasta de dente. Os resultados mostraram que quando há marcas conhecidas pelo consumidor no mercado e uma delas tem o preço superior porque começou a realizar uma campanha de CRM, os consumidores são propensos a pagar maior preço. Entretanto, quando o cenário é de uma marca que não é conhecida, eles não estão dispostos a pagar mais caro. Vale ressaltar que os consumidores se mostraram céticos quanto à honestidade dessas campanhas de CRM.
Editorial
Authors: Moraes Joysi
Published: January 2016

Editorial
Strategies to bridge the attainment gap
Authors: Sobel Daniel
Published: January 2016

Is it possible to halve the attainment gap in just six months? Drawing upon his work with one school, inclusion expert Daniel Sobel offers five lessons for effective whole-school Pupil Premium strategies
Slow and steady wins the Pupil Premium race
Authors: O'Connell Suzanne
Published: January 2016

Since its introduction in 2011, the Pupil Premium has become a key priority for schools. Last term one of the most in-depth reports to date on its use was published. Suzanne O'Connell summarises the main findings, all of which have clear practical implications for schools
Managing hypertension in diabetes
Authors: Morris David
Published: January 2016

The clinical evidence and options for controlling blood pressure in these patients are outlined by David Morris
New ways of treating COPD: patient focused prescribing
Authors: Bostock-Cox Beverley , Cottage Mann
Published: January 2016

A guide to selecting the right device for the appropriate patient. By Beverley Bostock-Cox
Get warmed up for the 2016 Olympic Games
Authors: Davis John
Published: January 2016

The Olympics provide a fantastic focus for cross-curricular study with opportunities to explore geography, history, physical education and more. John Davis gets you started.
Discover their talents
Authors: Cartwright Eva
Published: January 2016

Eva Cartwright urges TAs to re-think what ‘gifted and talented’ really means, and to implement strategies which allow all children to play to their particular strengths.
Chemotaxonomic Analysis of the Venom Composition within the Ant Genus Strumigenys (Hymenoptera, Formicidae) in Taiwan
Authors: Chien Chia-Hao , Lin Chung-Chi
Published: January 2016

In Taiwan, the ant genus Strumigenys is represented by 13 species, nine of which being endemic to this island. Classic morphological taxonomy can be complex and may lead to equivoque identification within this group. To clarify subtle species assignments, we investigated the venom composition of five Strumigenys species, using SPME extraction and GC/MS analyses, and searched for a suitable chemical marker. Our results indicate that three out of the five species tested showed enough specificity in their chemical profiles to allow clear differentiation. However, the two remaining species could not be distinguished from each other on the basis of their venom composition. We further assessed the phylogenetic relationships between the five species, analyzing both morphological and chemical characters. Our clusters revealed congruency between some species associations and suggested that the analysis of venom composition may apply, at least partially, to Strumigenys chemosystematics. However, important discrepancies also appeared, signifying that selective pressures for chemical diversification have operated differentially during the speciation and dispersal processes within this genus inTaiwan.
Heat shock proteins expression during thermal risk exposure in the temperate xerothermic ant Formica cinerea
Authors: Ślipiński Piotr , Pomorski Jan Jakub , Kowalewska Katarzyna
Published: January 2016

The abiotic conditions of the desert habitat fluctuate in a circadian rhythm of hot days and cold nights. Species living in desert habitats evolved many adaptations to increase their chances of survival. However, abiotic conditions in xerothermic habitats of a temperate climate are much different. Diurnal fluctuations are not as strong, but animals have to cope with seasonal changes and hibernate during the winter, which may potentially influence their adaptations to critical temperature conditions. We attempted to assess heat resistance adaptations using the example of a widely distributed xerothermic ant Formica cinerea. Using Real-Time PCR, we measured the expression of three heat shock protein genes (Hsp60, Hsp75, Hsp90) and assessed the adaptations of F. cinerea to enable foraging in risk prone conditions. The analysis of gene expression using the Generalized Linear Model surprisingly indicated that there was no significant effect of temperature when comparing workers from the control (23ºC) with workers foraging on the surface of hot sand (47-54ºC). As a next step we tried to estimate the threshold of a thermal resistance with the use of thermal chambers. Expression of all Hsps genes increase compare to the control group, expression of Hsp60 and Hsp90 continued up to 45ºC.
Use of flight interception traps of Malaise type and Attractive Traps for social wasps record (Vespidae: Polistinae)
Authors: Souza Marcos Magalhães , Perillo Lucas Neves , Barbosa Bruno Corrêa , Prezoto Fábio
Published: January 2016

The literature provides different methodologies for collecting social wasps, including, flight intercept trap type Malaise and Attractive trap, however, there is no consensus on its use. In this respect, the aim of this study was to evaluate the best use of Malaise traps and Attractive trap in biodiversity work of social wasps, and generate a collection protocol for the use of these traps. The study was conducted in the Parque Estadual do Rio Doce, east of the state of Minas Gerais, in the years 2000, 2001, 2002 and 2004 and in the Botanical Garden of the Federal University of Juiz de Fora, located in the southeastern state of Minas Gerais, in years 2011, 2012 and 2013. Were collected 15 species using Malaise traps, and traps Attractive, 26 species of social wasps were collected. Although the negative aspects of both traps are useful complementary methodologies surveys varying social wasps and it is recommended to choose for use in accordance with the logistical field.
Comparative Study of Resistance and Feeding Preference of 24 Wood Species to Attack by Heterotermes indicola (Wasmann) and Coptotermes heimi (Isoptera: Rhinotermitidae, Termitidae) in Pakistan.
Authors: Dugal Farkhanda Manzoor , Latif Muhammad Umair
Published: January 2016

Present study was conducted to evaluate the laboratory and field preference of 24 Pakistani wood species: Azadirachta indica (Neem), Pinus  roxberghii (Chir), Dalbergia sissoo (Sheesham), Populus deltoides (Popular), Albizzia lebbeck (Shirin), Abies pindrow(fir), Alstonia scholaris (Alstonia), Erythrina suberosa (Gul-e-nister), Eucalyptus citriodora (safaeda), Ficus religiosa (Bohar), Heterophragma adenophyllum (Beeri Patta), Melia azedarach (Derek), Pinus wallichiana (Chir), Terminalia arjuna (Arjun), Acacia Arabica (Kikar), Betula utilis (Birch) Cedrus deodara (Deodar), Cordia oblique (Lasura), Mangifera indi,a (Aam),Ehretia serrata Moringa oleifera (sohanjana), Putranjiva roxburghii (Lucky bean), Syzygium cumini (Jaman) and  Zizyphus jujube (Berry) against attack and damage by termite species Heterotermes indicola  and Coptotermes heimi. Two weeks laboratory and four weeks field feeding trials were performed as described in standards of the American Wood Protection Association (AWPA, 1997). Samples of each of the 24 wood species were individually exposed to 100 termites (10% soldiers); and termite mortality, wood mass loss and visual appearance of the samples (on a scale of 0-10) were recorded. Results indicated that by no choice feeding assay, Populus deltoides was the most preferred and Dalbergia sissoo was the least preferred among the 24 wood species tested in laboratory against Heterotermes indicola and Coptotermes heimi. Field studies by no choice feeding test against mixed termites and C. heimi indicated D. sissoo the least palatable and Mangifera indica the most palatable wood. So it is recommended that though all 24 species evaluated in the present study differ in their susceptibility to termite attack, they would require additional protection to avoid termite attack.
Minding the gap: the barriers and facilitators of getting evidence into policy when using a knowledge-brokering approach
Authors: Reid Garth , Connolly John , Halliday Wendy , Love Anne-Marie , Higgins Michael , MacGregor Anita
Published: January 2016

Transferring knowledge into action is challenging. Ward et al (2009a) developed a framework for bridging this gap. This article describes what helps and hinders getting knowledge into action when using this approach in the field of mental health. Four areas of Scotland were selected which had used resources to inform local planning and participants were interviewed. The resources helped galvanise local action on outcomes and the transfer of evidence into policy. It also facilitated building stronger relationships. Using a knowledge-brokering approach to transfer knowledge into action yielded positive feedback from participants and may have mitigated some prior barriers and enhanced facilitators.
Education for critical practice in mental health: opportunities and challenges
Authors: Sapouna Lydia
Published: January 2016

This article discusses an approach to mental health education that aims to prepare students to become critical practitioners with the vision and skills to understand human distress in life contexts. This approach questions traditional knowledge-formation in mental health as it is not focused on psychiatric diagnoses as a tool to learn about ‘mental illnesses’. It also involves rethinking issues of power, language and identity by encouraging students to question what is often experienced as an oppressive, coercive mental health system and by putting the voice of service-users/survivors in the centre of practice. Such an education often clashes with the ethos and practice of current mental health services, which, despite heralding a recovery agenda, in their majority, remain medical in focus. Drawing from the author’s experience in mental health education, the article highlights the potential of educational processes to transform hegemonic practice and the challenges and opportunities contained in this process.
Work in progress – Authentic Movement: Danced and moving active imagination
Authors: Chodorow Joan
Published: January 2016

In 2014, TANTER, The Dance Movement Therapy Association of the Czech Republic  invited Chodorow to be among the international dance movement therapists who brought and continue to bring theoretical foundations and direct experience to their early and continuing intensive three and four year DMT training programs. She decided to record and share elements of their work together, with special attention to Authentic Movement, including many creative combinations, seen and explored from diverse perspectives. This article is largely informed and inspired by the psychology of C. G. Jung and the early contributions of Tina Keller, Trudi Schoop, Alma Hawkins, and Mary Whitehouse. It deepens our understanding of dyad, triad and long circle work; symbolic play; memory, imagination, the senses, emotions and their development. The conclusion describes a playful introduction to elements of neuroanatomy via symbolic enactment.
Towards a new ontology and name for ‘Authentic Movement’
Authors: Goldhahn Eila
Published: January 2016

The Discipline of Authentic Movement and related practices grouped under the term Authentic Movement appear, by merit of their name, to purport the possibility of teaching and learning movement that is authentic. This article critiques the term authentic with regard to movement and instead offers an historic and philosophical understanding of the term exploring the genealogy of the practice’s name. Further the article develops a case for a new ontology of the methodological workings of the Discipline of Authentic Movement by listing and exploring some of its key qualities. The article expands previous research of its precursor of 2009: ‘Is Authentic the correct name to describe the Discipline of Authentic Movement’, and proposes and explains an alternative term for the practice, namely the MoverWitness or, simply, Movers and Witnesses.
Speak: Authentic Movement, ‘embodied text’ and performance as research
Authors: Meehan Emma
Published: January 2016

In this article, I will examine the relationship between movement and language in my Authentic Movement practice, focussing on writing for and about performance. Although somatic practices such as Authentic Movement promote body-mind integration and often use language-based reflection on experience, I have often encountered conflicting perspectives on the relationship between body and language across the contexts that I work in. In order to investigate ideas of division and integration between movement and language, I undertook a performance as research project called Speak. Working with Janet Adler’s ‘embodied text’ as a strategy for exploration, which is a deepening of the process of study and practice with words in Authentic Movement, I addressed the question: What is the relationship between physical movement and language in Authentic Movement practice? However, the practice as research also uncovered issues of bringing pre-rehearsed scores from Authentic Movement and writing into performance. As a result, I propose ideas of conversation and dialogue as a form of movement-language exchange in Authentic Movement practice and performance. More broadly speaking, this project has led me to investigate methods from Authentic Movement practice that can support discussions of movement-based performance in practice as research. With the emphasis on body-mind integration and articulation of experience in Authentic Movement, the approach could offer methods to the increasing number of practitioner-researchers entering the academy and grappling with issues of reflecting on embodied practice through writing.
Mindful Authentic Movement: A way of working with Mindfulness, Character Analysis and Authentic Movement
Authors: Hjelland Stig A.
Published: January 2016

This article briefly contextualizes and then outlines what I am referring to as ‘Mindful Authentic Movement’. Drawing from body-oriented psychotherapy and Authentic Movement, this work seeks to establish a clear and practical tool for working with free and authentic expression of the self. I argue that expressions from, and deep contact with, the core self for a client or a group of individuals can be facilitated by a set of pedagogical rules aimed at suspending or even transforming characterological defence systems that might impede true self expression. Reich’s ‘Character Analysis’ and ‘Mindfulness’ as a state of consciousness emerge as key to the process by which transformation is possible.
A COMPARISON OF THE TENSILE STRENGTH OF PLASTIC PARTS PRODUCED BY A FUSED DEPOSITION MODELING DEVICE
Authors: Beniak Juraj , Križan Peter , Matúš Miloš
Published: January 2016

Rapid Prototyping systems are nowadays increasingly used in many areas of industry, not only for producing design models but also for producing parts for final use. We need to know the properties of these parts. When we talk about the Fused Deposition Modeling (FDM) technique and FDM devices, there are many possible settings for devices and models which could influence the properties of a final part. In addition, devices based on the same principle may use different operational software for calculating the tool path, and this may have a major impact. The aim of this paper is to show the tensile strength value for parts produced from different materials on the Fused Deposition Modeling device when the horizontal orientation of the specimens is changed.
VERIFICATION OF CENSUS DEVICES IN TRANSPORTATION RESEARCH
Authors: Petrů Jan , Kludka Michal , Krivda Vladislav , Mahdalova Ivana , Zeman Karel
Published: January 2016

The article presents a comparison of three devices and two methods that are used to count traffic flow. All measurements were carried out at a roundabout in Ostrava, where the following devices were used: Viacount II, Icoms TSM-SA, and Nu-Metrics NC-200 traffic analyzers. The methods of manual counting of vehicles and of counting vehicles based on video footage were used. The article also provides a comparison of the results obtained, namely in terms of traffic intensity, and of the measurements of the length and speed of vehicles. Further, we evaluate the results and explore the deviations from reality and the reasons why they occur. The article concludes with the recommended procedure designed to eliminate the identified problems, in order to ensure the most accurate results, with no significant deviations.
Impact of macro-scale circulation types on the occurrence of frosty days in Poland
Authors: Tomczyk Arkadiusz Marek
Published: January 2016

The research aimed at determining the variability of occurrence of frosty days in Poland and defining the impact of macro-scale circulation types on the occurrence of these days from December to March. The study used daily data on the minimum, maximum and mean daily air temperature for 15 stations located in Poland from 40 winter seasons between 1970/71 and 2009/10. During that period, a decrease in the number of frosty days was noticed across the greater part of Poland; still, these changes were not statistically significant. The conducted research study showed that, of macro-scale circulation types, the North Atlantic Oscillation and Scandinavian type had the most significant impacts on the number of frosty days in Poland.