bluuebunny/crossref_metadata_2025 huggingface dataset:
RANCANG BANGUN ALAT UKUR BERAT BADAN OTOMATIS BERBASIS ANDROID
Authors: Tarigan Isagani Zakaria , Sijabat Salomo
Published: September 2022

Design and construction of an Android-based automatic weight measurement tool has been carried out. This research was made because of the demands for sophisticated medical support equipment with all the capabilities it has that continues to develop so that effective and efficient medical support equipment can be produced. This tool is designed with the aim of providing information about the measurement data of weight and height to users. Measurement results data will be sent to Android in the form of messages to be stored using the android database system storage.This research method uses qualitative methods, namely: study literature and literature and conduct experiments on the circuit design made, then test the function of the tool with a scale to determine the accuracy of the work of this tool. This tool is made by utilizing the Load Cell sensor as conversion then will sent via GSM SIM 800L, and the data is displayed via the application and SMS on the patient's Android.The test results show that the weight obtained is the result of the load cell sensor measurement. seen the percentage error value for each measurement, which allows the sensor to read errors and possible interference from the compiler program. As long as the% error does not exceed 3%, the module design and build an automatic weight measuring instrument, can be used properly
ANALISA PRINSIP KERJA FLOW SENSOR DALAM MENGETAHUI VOLUME TIDAL MESIN ANASTESI VENTILATOR
Authors: Gulo Kharisda Novtri Gratia , Rahmah Siti
Published: September 2022

Flow sensors have an important role in ventilator anesthesia machines, where flow sensors function to monitor air flow and pressure to obtain the amount of air volume and pressure delivered to the patient. If the volume of air entering the patient does not match the capacity of the patient's lungs, it can endanger the patient. So that a flow sensor is needed in order to know the accuracy of the volume that will be given to the patient.
ANALISA KALIBRASI ALAT PHOTOTHERAPY UNIT MENGGUNAKAN PHOTOTHERAPY RADIOMETER
Authors: Mendrofa Jesni Juwita , Yulizham Yulizham
Published: September 2022

Jaundice in newborns from January 2013 to December 2015, with a sample size of 223 babies. To treat jaundice in babies, Phototherapy is used. Phototherapy is the first action therapy for newborns with hyperbilirunemia. The provision of effective phototherapy is the main factor in the rapid management of hyperbilirubinemia.
RANCANG BANGUN ALAT WATERBATH DI LENGKAPI SENSOR SUHU MENGGUNAKAN MIKROKONTROLER ATMEGA328
Authors: Arsa Okkay Wahyu , Priyulida Fitria
Published: September 2022

The purpose of designing this tool is to develop a water bath device beforehand so that it can be controlled from the display when it is set using an ATMEGA 328 microcontroller equipped with a temperature sensor and to carry out testing and measuring tools, with temperature selection from 30 c to 90 c, at Previous research was only able to adjust the temperature from 37 c to 60 c and this tool is also more flexible, the temperature sensor in this water bath tool uses the DS18B20 sensor which functions to find out the temperature in this tool. The desired temperature and timer will then be visible on the LCD display then the buzer will sound to indicate the process is complete.The method used in this research is experimentation with system design, tool testing and conclusion drawing. but before doing the design, the timer test is measured 6 times using a stopwatch at a temperature of 50 c and gets an average time of 305 results. 605, and 905 seconds and temperature testing was measured 6 times using a comparison of the thermometer temperature at 5 minutes and the average temperature results were 35.11 c, 45.11 c, 55.11 c, and 65.11 c , Based on data collection that has been done using a stopwatch and thermometer comparison, this water bath device can produce the desired temperature. The ability of this tool can withstand a maximum temperature of 90 c.
PENGARUH DAYA HISAP TERHADAP ALAT SUCTION PUMP
Authors: Riansyah Iqbal Eka , Dabukke Hotromasari
Published: September 2022

Research on the effect of suction power on the YB-DX23B smaf suction pump has been carried out.The method used in this research is quantitative experiment by measuring, testing and collecting data directly on the suction pump. The measuring instrument used is Vacum Gauge Meter. By using water as an object to replace blood and with a predetermined 10 second timer set, set the volume to adjust the volume of water you want and set the regulator to adjust how much suction power is needed.This research was conducted at the Electronics Laboratory of Sari Mutiara University- Indonesia. The results of this research are when the regulator is set at parameter -100 mmHg, the output on the vacuum gauge meter becomes -10 cmHg and the liquid is inhaled as much as 700 ml, when the regulator is set at parameter -200 mmHg, the output on the vacuum gauge meter becomes -20 cmHg and the liquid is inhaled as much as 1000 ml, when the regulator is set at the parameter -300 mmHg, the output on the vacuum gauge meter becomes -30cmHg and the liquid sucked is 1300 ml, and the regulator is set to the parameter -400 mmHg and the output on the vacuum gauge meter becomes -40 cmHg and the liquid is inhaled as much as 1500 ml.Measurements using a vacum gauge on the suction pump according to the settings set by the user. The greater the vacuum power, the faster the process of suctioning thevolume of liquid in
ANALISA KALIBRASI ALAT INFANT WARMER MENGGUNAKAN ALAT INCUBATOR ANALYZER
Authors: Malau M. Suganda , Yulizham Yulizham
Published: September 2022

Infant warmer is one of the electromedical devices used to provide comfort and warmth to newborns, where the baby needs a temperature that is in accordance with the temperature in the mother's womb, which is between 34oC – 37oC. The purpose of this research is to study the Calibration technique and the calculation of the uncertainty of temperature measurement data.The results obtained from the calibration and calculations are +- 0,54oC for temperature. From these results, it was stated that the infant warmer was declared fit for use. As a rule, the test pass threshold value is +- 2 oc for temperature.
ANALISA PEMELIHARAAN ALAT INFUS PUMP DI RUMAH SAKIT UMUM SIBUHUAN
Authors: Harahap Siti Hariati Asmeri , Rahmah Siti
Published: September 2022

An infusion pump is a very important tool to assist doctors in treating patients who are in treatment.Continous health care needs to be supported by equipment that is always in a ready to use condition and can function properly.Formulation of the problem: 1. How is the implementation of technical maintenance of the infusion pump in the hospital. 2. How the performance and repair of the infusion pump in the hospital. Objectives: 1. Todetermine the maintenance of the infusion pump in the hospital. 2. To find out the troubleshooting of the infusion pump.This research method is descriptive research type,aims to analyze the maintenance of the infusion pump and also to determine the results of the data obtained after observation and conclusion.The results of research conducted at the general hospital in the Sibuhuan area.This research,maintenance of the infusion pump was carried out in three stages of maintenance,namely: Monthly maintenance and quarterly maintenance and 6 monthly maintenance.The conclusion from the results of the discussion of research carried out on maintenance of the infusion pump can be concluded that the maintenance is carried out properly.
RANCANG BANGUN ALAT WATERBATH DI LENGKAPI SENSOR SUHU MENGGUNAKAN MIKROKONTROLER ATMEGA328
Authors: Arsa Okky Wahyu , Priyulida Fitria
Published: September 2022

The purpose of designing this tool is to develop a water bath device beforehand so that it can be controlled from the display when it is set using an ATMEGA 328 microcontroller equipped with a temperature sensor and to carry out testing and measuring tools, with temperature selection from 30 C to 90 C, at Previous research was only able to adjust the temperature from 37 C to 60 C and this tool is also more flexible, the temperature sensor in this water bath tool uses the DS18B20 sensor which functions to find out the temperature in this tool. The desired temperature and timer will then be visible on the LCD display then the buzer will sound to indicate the process is complete.The method used in this research is experimentation with system design, tool testing and conclusion drawing. but before doing the design, the timer test is measured 6 times using a stopwatch at a temperature of 50 C and gets an average time of 305 results. 605, and 905 seconds and temperature testing was measured 6 times using a comparison of the thermometer temperature at 5 minutes and the average temperature results were 35.11 C, 45.11 C, 55.11 C, and 65.11 C , Based on data collection that has been done using a stopwatch and thermometer comparison, this water bath device can produce the desired temperature. The ability of this tool can withstand a maximum temperature of 90 C.
PENGARUH DAYA HISAP TERHADAP ALAT SUCTION PUMP
Authors: Riansyah Iqbal Eka , Dabukke Hotromasari
Published: September 2022

Research on the effect of suction power on the YB-DX23B smaf suction pump has been carried out.The method used in this research is quantitative experiment by measuring, testing and collecting data directly on the suction pump. The measuring instrument used is Vacum Gauge Meter. By using water as an object to replace blood and with a predetermined 10 second timer set, set the volume to adjust the volume of water you want and set the regulator to adjust how much suction power is needed.This research was conducted at the Electronics Laboratory of Sari Mutiara University- Indonesia. The results of this research are when the regulator is set at parameter -100 mmHg, the output on the vacuum gauge meter becomes -10 cmHg and the liquid is inhaled as much as 700 ml, when the regulator is set at parameter -200 mmHg, the output on the vacuum gauge meter becomes -20 cmHg and the liquid is inhaled as much as 1000 ml, when the regulator is set at the parameter -300 mmHg, the output on the vacuum gauge meter becomes -30cmHg and the liquid sucked is 1300 ml, and the regulator is set to the parameter -400 mmHg and the output on the vacuum gauge meter becomes -40 cmHg and the liquid is inhaled as much as 1500 ml.Measurements using a vacum gauge on the suction pump according to the settings set by the user. The greater the vacuum power, the faster the process of suctioning thevolume of liquid in.
ANALISA KALIBRASI ALAT INFANT WARMER MENGGUNAKAN ALAT INCUBATOR ANALYZER
Authors: Malau M. Suganda , Yulizham Yulizham
Published: September 2022

Infant warmer is one of the electromedical devices used to provide comfort and warmth to newborns, where the baby needs a temperature that is in accordance with the temperature in the mother's womb, which is between 34oC – 37oC. The purpose of this research is to study the Calibration technique and the calculation of the uncertainty of temperature measurement data.The results obtained from the calibration and calculations are ± 0,54oC for temperature. From these results, it was stated that the infant warmer was declared fit for use. As a rule, the test pass threshold value is ± 2 oC for temperature.
FORMULASI SEDIAAN BLUSH ON DARI SARI BUAH STROBERI (Fragaria vesca L) SEBAGAI PERONA PIPI
Authors: Sianipar Artha Yuliana , Nurbaya Siti , Adiansyah Adiansyah , Sitanggang Eva Priasanti
Published: September 2022

Colorisone of the determining factors for the quality of cosmetics. The use of synthetic colors in blus her can cause irritation on facial skin. Because of that, wetried to make a blush preparation using natural dyes, namely strawberries (Fragariavesca L). The purpose of this study was to make blushusing natural dyesfromstrawberries (Fragariavesca L). The juice is obtaineddirectly using a juicer machine, then heated in a waterbath /Waterbath to obtain a thick juice of strawberry fruit (Fragariavesca L) with a concentration of 15; 25; 35%. The resultsshowedthatthepreparationwashomogeneous, remainedstable, did not cause irritation, wassafe for the skin because thep Hofthepreparation was still in the normal skin phrange of 4.5-6.5, and was quiteliked by the respondents. The conclusion of this study shows that strawberry juice (Fragariavesca L) canbeused as a blush (blush), but the resulting colorisless visible.
PENETAPAN ANGKA KAPANG KHAMIR (AKK) PADA REMPAH-REMPAH YANG DIJUAL DI PASAR SRI GUNTING MEDAN
Authors: Silalahi Yosy Cinthya Eriwaty , Manurung Kesaktian , Halawa Putri Niat Salma
Published: September 2022

Spices containing fungal contamination exceed the stipulated limit of 1x104 colonies/g which will affect the stability of the preparation and aflatoxins that are harmful to health such as liver cancer. This study aims to determine the value of the yeast mold number (AKK) in spices at the Sri Gunting market, Medan. The population in this study were spices in the form of wet powder, namely turmeric (Curcuma longa Linn.), ginger (Zingiber officinale Rosc.), and temulawak (Curcuma xanthorhiza Roxb.), and 250 grams of each ingredient was taken from four spice traders. with location criteria such as on the edge of a highway, near a ditch/gully, inside a kiosk, and near a meat seller as a sample. Subjects of research and observations are presented in the form of tables and figures which are then analyzed descriptively. The results of the study found that the AKK of spices sold at the Sri Gunting market in Medan was equal to trader A (turmeric 16.1x10^4, Ginger 7.9x10^4, Temulawak 11.1x10^4cfu/g), trader B (turmeric > 150, Ginger 11.5x10^4Temulawak 18x10^4cfu/g), merchant C (turmeric 12.2x10^4, Ginger 6.1x10^4, Temulawak 4.5x10^4cfu/g), and merchant D (turmeric >150, Ginger 10.9x10^4, Temulawak >150cfu/g) which means that the AKK contained from spices sold at the Sri Gunting market in Medan does not meet the requirements according to the Food and Drug Supervisory Agency (BPOM).
FORMULASI SEDIAAN KRIM DEODORANT EKSTRAK ETANOL DAUN BELUNTAS (Plucea indica Less.) SEBAGAI PENCEGAH BAU BADAN
Authors: Sinaga Eka Margaret , Supartiningsih Supartiningsih , Maimunah Siti , Jayadi Nikmat
Published: September 2022

Beluntas is one of the plants that is often used as traditional medicine. Beluntas leaves have antimicrobial activity against various kinds of bacteria. This study aims to formulate Beluntas leaf extract (Plucea indica Less.) in the form of a deodorant cream that functions as a deterrent to body odor. The research method was carried out experimentally which included extract preparation, formulation using Beluntas leaf extract (Plucea indica Less.) with a concentration of 5%, 7.5%, 10%, preparation quality test, and hedonic test. The results of the formula The deodorant cream preparation can be used properly and can prevent sweating for 8 hours and the deodorant cream does not cause irritation and provides comfort when used, from formulas 1, 2, and 3, all the results are good to prevent sweating in the armpits but, the formula favored by the volunteers was formula 1 because the aroma was just right unlike formula 2, and formula 3 which had a slightly more pungent aroma, and similarly to the color in formula 1, the color was light green, unlike formula 2, and formula 3 which tended to be lighter in color. dark green. Beluntas leaf ethanol extract can be used to prevent body odor, and the extract can be used as a natural deodorant cream to prevent body odor.
UJI PENINGKATAN KADAR ASAM AMINO PADA TAPE KETAN HITAM DENGAN PENAMBAHAN SARI BUAH NANAS DENGAN METODE SPEKTROFOTOMETRI SINAR TAMPAK
Authors: Supartiningsih Supartiningsih , Maimunah Siti , Silalahi Yosy Cinthya Eriwaty
Published: September 2022

Amino acid levels in sticky rice tape are still relatively low, while amino acids themselves are food substances for body growth. Pineapple contains the enzyme bromelain. This enzyme is one of the protease enzymes that can hydrolyze protein, therefore it can increase amino acid levels. This study aims to determine the increase in amino acid levels in black sticky rice tape with the addition of pineapple juice and to determine the effect of adding pineapple juice to amino acid levels in black sticky rice tape. In the process of making black sticky rice tape, 25 ml 50 ml of pineapple juice was added per 500 grams each, while one treatment did not add pineapple juice as a control. Black glutinous rice that has been fermented for 2-3 days was tested for increased levels of amino acids by using visible light spectrophotometry. The sample of black glutinous tape without the addition of pineapple juice obtained an average content of 4.73%, on the sample of black glutinous tape with the addition of 25 ml of pineapple juice the average content obtained was 6.50%, and the sample of black sticky rice tape with the addition of 50 ml pineapple juice the average level obtained was 7.76% and gave the effect of increasing amino acid levels on black sticky rice tape.
AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2 OLEH SENYAWA ALKALOID DARI ATTARASA (Litsea cubeba (Lour.)Pers.) SECARA IN-SILICO
Authors: Marpaung Jon Kenedy , Tambuan Melisa Rekayana
Published: September 2022

Attarasa (Litsea cubeba (Lour.) Pers.) is a mountain plant known as "Mountain pepper" or "Mountain Pepper". This plant contains alkaloids, such as Oblongine; Actinodaphine; Isoboldine; Cassameridine; Coclaurine; Corydine; Corytuberine; Dicentrine; Laurotetanine; Lindcarpine; Isocorydine; Isodomesticine; Juziphine; N-Methylcoclaurine; N-Methyllaurotetanine; N-Methyllindcarpine; Norcorydine; Norisoboldine; Norisocorydine; Xanthoplanine. Alkaloids in Attarasa (Litsea cubeba (Lour.) Pers.) have properties such as antimicrobials. This study aimed to determine the inhibition of the protease enzyme 6LU7 of the SARS­­-CoV-2 virus by an alkaloid compound from Attarasa (Litsea cubeba (Lour.) Pers.) by using the in silico tethering method. The in silico tethering process is carried out using the PLANTS program and visualized using the MOE2008 program. The protease enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. Two- and three-dimensional models are generated using the Marvin Sketch program. The resulting docking value is evaluated as a result of the docking process. The results of this study indicate that the binding of alkaloid compounds from Attarasa (Litsea cubeba (Lour.) Pers.) to 6LU7 expression gave valid results in silico. The compound N-Methylcoclaurine, Coclaurine, and Laurotetanin inhibited the protease enzyme 6LU7 with the best score close to the comparative value of Lopinavir and Remdesivir and produced 7 amino acid residues that were bound to each other, namely val_114, val_13, leu_115, phe_150, gly_140, val_140, and ser_147.
ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR LAUT DAN UDANG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA)
Authors: Silalahi Yosy Cinthya Eriwaty , Marpaung Jon Kenedy , Supartiningsih Supartiningsih
Published: September 2022

Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in rivers, lakes, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine levels of mercury metal contamination in seawater fish, including shark, mackerel, salmon, tuna, red snapper, and white shrimp. Sample preparation was carried out by wet digestion method using a microwave digestion device. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is 253.7 nm. The results showed that mercury in sharks was 0.2045 ± 0.0099 mg/kg, mackerel 0.4184 ± 0.0297 mg/kg, salmon 0.3848 ± 0.0794 mg/kg, tuna fish 0.3706 ± 0.0674 mg/kg, snapper 0.4088 ± 0.0397 mg/kg, and shrimp 0.4289 ± 0.0813 mg/kg. The results of the analysis showed that of the six samples of seawater fish that had been tested, the maximum metal contamination limit determined by SNI 7387 the Year 2009 was 0.5 mg/kg.
UJI EFEK EKSTRAK ETANOL DAUN SALAM (Syzygiumpolyanthum) SEBAGAI DIURETIKA PADA TIKUS PUTIH JANTAN
Authors: Manurung Kesaktian , Marbun Novarianti , Empindonta Salomo Joseph
Published: September 2022

Bay leaf is a plant that one of its benefits is as a diuretic. Diuretics are drugs that act directly on the kidneys and increase the excretion of urine and sodium salts. The aim of the study was to determine the diuretic effect of ethanol extract of bay leaf (EEDS) on male white rats. The study used 25 male white rats, divided into 5 treatment groups: negative control group (CMC suspension 0.5%), positive control (furosemide suspension at a dose of 3.6 mg/kg BW), and a test group EEDS suspension at a dose of 100 mg/kg. BW, 200 mg/kg BW and 300 mg/kg BW. The test preparation was given orally to rats and then observed in a modified metabolic cage for 6 hours. The results of simplicia phytochemical screening showed positive for flavonoids, saponins and tannins. The results of EEDS characterization included a total ash content of 3.66%, water-soluble extract content of 3.69%, and ethanol-soluble extract content of 3.65%. The results showed that EEDS at a dose of 300 mg/kg BW showed the best diuretic effect compared to 200 mg/kg BW and 100 mg/kg BW, but the effect was lower than S. Furosemide 3.6 mg/kg BW. The results of the ANOVA EEDS test at doses of 100, 200 and 300 mg/kg BW had significant differences.
PEMANFAATAN LIMBAH CAIR TAHU MENJADI Nata de Soya MENGGUNAKAN BAKTERI Acetobakter xylinum
Authors: Zuhairiah Zuhairiah , Marpaung Jon Kenedy , Silitonga Maringan
Published: September 2022

Nata de Soya merupakan salah satu jenis pangan yang diperoleh dari pengolahan limbah cair tahu yang berbahan dasar kedelai. Penelitian ini bertujuan untuk memanfaatkan limbah cair tahu yang sering terabaikan dan menjadi penyebab rusaknya lingkungan perairan dekat perindustrian pembuatan tahu. Nata de Soya dibentuk oleh bakteri Acetobacter xylinum yang merupakan bakteria erob. Masing-masing perlakuan difermentasi selama 8-14 hari, parameter yang diamati yaitu berat nata, kadar air, kadar serat dan selulosa Nata de Soya selama 8-14 hari. Pada penelitian ini didapat data ketebalan Nata de Soya dengan perlakuan 1, 2, dan 3 dengan kosentrasi 5, 10, dan 20% starter bakteri yaitu, 2,4503 gr, 2,8922 gr, dan 2,9226. Pada berat nata didapat 0,21 cm, 0,82 cm, dan 1,53 cm. Kandungan kadar air pada Nata de Soya pada perlakuan 1,2 dan 3 dengan kosentrasi masing-masing 5, 10, dan 20% yaitu 82,71, 83,71%, dan 84,17%%. Kandungan kadar serat Nata de Soya pada perlakuan 1, 2, dan 3 dengan kosentrasa bakteri 5, 10 dan 20% didapat 49,90%, 50,74% dan 54,02%. Pada uji kadar selulosa menggunakan FTIR dengan sampel 0,4 g nilai tertinggi didapat sebanyak 3361,12 menunjukan adanya gugus aldehid dari selulosa acetat. Pemanfaatan limbah cair tahu menjadi Nata de Soya menggunakan bakteri acetobacter xylinum dapat menjadi alternative pengolahan limbah cair tahu.
PENGARUH VARIASI WAKTU FERMENTASI TERHADAP KADAR ETANOL HASIL FERMENTASI SINGKONG KUNING (Manihotutillissima Pohl)
Authors: Maimunah Siti , Zuhairiah Zuhairiah , Sianipar Artha Yuliana
Published: September 2022

Cassava is an agricultural commodity that is widely grown in Indonesia and is an important source of carbohydrates after rice with a content of 34.7%. Yellow cassava is usually served in the form of tape through a fermentation process. This study aims to determine the effect of variations in fermentation time on ethanol content resulting from yellow cassava fermentation. This study used an experimental method with the distillation method using yellow cassava samples which were fermented for 72 hours, 96 hours, and 120 hours. The results of this study indicate that there is an effect of time variation on the ethanol content of fermented yellow cassava with a value of 0.93% (72 hours), 1.00% (96 hours), 1.27% (120 hours) which has a very significant effect (p < 0.01 >). The yield of this fermentation can be determined using the alcohol BJ table.
PENENTUAN KADAR PROTEIN PADA SUSU KEDELAI (Glycinemax L. Merril) DENGAN MENGGUNAKAN METODE Kjeldahl
Authors: Nurbaya Siti , Supartiningsih Supartiningsih
Published: September 2022

Soy milk has a combination of nutrients that are almost the same as cow's milk, but soy milk has low cholesterol, gluten, and lactose levels so that soy milk is safe for consumption by people with lactose intolerance, vegetarians, and is also safe for health. Determination of protein content that is most often done is the determination of crude protein which aims to determine the total amount of protein in food ingredients. The most commonly used protein assay method is the Kjeldahlmethod. This study aims to determine the protein content of soy milk packaged in boxes that are made by themselves and sold in traditional markets. The samples used in this study used packaged soy milk, traditional soy milk, and homemade soy milk. The results showed that the protein content of the three samples determined by the Kjeldahlmethod was 3.35±0.0816% traditional soy milk, 2.31±0.3562% box-packed soy milk, and 2.62±0.2495% whole milk. Homemade soybeans. The protein content in box-packed soy milk, homemade soy milk, and traditional soy milk haveeach met the requirements of SNI (1995). The results showed that the protein content of traditional soy milk was greater than that of packaged soy milk and homemade soy milk.
AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2 OLEH SENYAWA DERIVAT KURKUMINOID SECARAIN SILICO
Authors: Purwandari Vivi , Silalahi Yosy Cinthya Eriwaty , Sianipar Artha Yuliana , Mendrofa Ledy Lenta Dirga Indah
Published: September 2022

Penggunaan curcumin sebagai penghambat enzim protease 6LU7 virus SARS-COV-2 sebagai bahan alam yang digunakan dalam terapi pendukung untuk menangani COVID-19 masih terdapat perdebatan dikarenakan curcumin dapat meningkatkan kadar protein ACE2 yang merupakan homolog ACE. Protease inhibitor disarankan menjadikan didatobat yang baik untuk menghentikan siklus hidup virus. Penelitian ini bertujuan untuk mengetahui aktivitas penghambatan enzim protease sars-cov-2 senyawa derivate kurkuminoid secara insilico, untuk mengetahui manfaat yang terdapat di dalam senyawa derivate kurkuminoid, dan untuk mengetahu ini lai-nilai senyawa derivate kurkuminoid didalam penghambatan enzim protease sars-cov-2. Metode pada penelitian ini menggunakan metode penelitian secara eksperimental dengan cara menguji aktivitas senyawa Derivat Kurkumin terhadap penghambatan enzim protease 6LU7 Virus SARS CoV. Hasil penelitian ini diperoleh bahwa poses penambatan enzim protease 6LU7 virus SARS-CoV-2 dinyatakan valid, sehingga dapat digunakan untuk penambatan molekulsenyawa uji Derivat Kurkuminoid secara in silico. Senyawa uji  Derivat Kurkuminoid mampu menghambat enzim protease 6LU7 Virus SARS-CoV-2. Docking score senyawa uji Derivat Kurkuminoid pada enzim protease 6LU7 virus SARS-CoV-2 lebih rendah dari pembanding. Hasil visualisasi docking terdapat beberapa residu asam amino yang saling berinteraksi diantaranya terdapat ikatan hydrogen.
UJI AKTIVITAS ANTIBAKTERI MADU HUTAN TERHADAP BAKTERI Bacillus cereus
Authors: Supartiningsih Supartiningsih , Marpaung Jon Kenedy , Silalahi Yosy Cinthya Eriwaty , Turnip Icha Wahyuni
Published: September 2022

Honey is a thick sweet liquid which comes from bees which can cure many diseases and is antibacterial. Antibacterial potential of honey caused by the content of active compounds, low moisture content, high osmolarity, hydrogen peroxide content, and low pH.The aim of this study was to determine the antibacterial activity of forest honey on Doloksaribu, Simalungun district on the growth of Bacillus cereus bacteria.Experiment research method includes the analysis quality of honey, includes checking moisture content, ash content, pH tested, acidity, viscosity, spesific gravityphytochemical screening, and antibacterial activity test ith disk diffusion method use blank disk with each concentration 25%, 35%, 45%, 55%, and 65%, positive control using erythromycin and negative control sterile distilled water. Organoleptic test conducted on forest honey gave results that honey reach the requirements for good quality. The result of moisture and ash content test and pH test reach of SNI 3545: 2013 about honey. Antibacterial activity test of forest honey with concentration 25%, 35%, 45%, 55%, and 65% against Bacillus cereus showed that there was an inhibitory around the blank disc, namely 10,16 mm, 13 mm, 15,6 mm, 21,6 mm, and 22,6 mm. The greatest inhibition of forest honey occurred at the highest concentration that is 65% (22,6 mm).
PENETAPAN KADAR KAFEIN DARI BUBUK KOPI YANG DIPEROLEH DARI KOTA SIDIKALANG SECARA SPEKTROFOTOMETRI UV
Authors: Maimunah Siti , Supartiningsih Supartiningsih , Chandra Devina
Published: September 2022

Coffee has many health benefits, such as stimulating the central nervous system, with the effect of relieving fatigue, drowsiness, and also in creasing concentration power. How ever, excessiveuse of caffeine can cause heart palpitations, stomachdi sorders, and shaking hands. Caffeine levels in coffee circulating in the market vary, dueto a mixtureofotheringredients. For this reason, the National Standardization Agency (BSN) has set a standard for caffeine content in coffeepowder, whichis 0.455%-2% w/w (SNI 01-3542-2004), so that if there is coffee containing high levels of caffeine, it needs to be decaffeinated. tosuppresstheactivityofcaffeine in thebody. The purpose of this study was to determine the caffeine content of Arabica coffee powder and Robusta coffee. The samples determined were 2 types of arabica coffee powder, namely those obtained from high stems and low stems, and 1 robusta coffee powder. Sampling was carried out purposively, and as says were determined using ultraviolet spectrophotometry after extraction using chloroform. The results showed that the caffeine content of high-stem Arabica coffee powder was 1.675% (16.75mg/g), low-stemmed 0.546% (5.462 mg/g), and 0.818% (8.18mg/g) of Robusta coffeegrounds. In conclusion, the caffeine levels of the three samples determinedmet the requirements of the Indonesian National Standard.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KEMANGI (Ocimumbasilicum L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcusaureus
Authors: Manurung Kesaktian , Marpaung Jon Kenedy , Mardianis Mardianis
Published: September 2022

Basil (Ocimumbasilicum L.) is one of the natural plants that is easily obtained in Asia such as Indonesia which has medicinal properties. Basil leaves contain flavonoid compounds, tannins, saponins, and steroids/triterpenoids. These compounds are known to have antibacterial activity. This study aims to determine the antibacterial activity of the ethanolic extract of basil leaves (Ocimumbasilicum L.) against Staphylococcus aureus bacteria. This research is experimental. The test was carried out through several stages including material collection, preparation of simplicia, making ethanol extract of basil leaves, and testing the inhibitory power of basil leaves against Staphylococcus aureus bacteria. The ethanol extract of basil leaves was made by the maceration method using 96% ethanol and concentrated with a rotary evaporator to obtain a thick extract from basil leaves. Antibacterial activity was tested by the agar diffusion method using disc paper. The results of the antibacterial activity test showed that the ethanolic extract of basil leaves inhibited the growth of Staphylococcus aureus bacteria at concentrations of extracts of 5%, 10%, 15%, 20%, and 25% with inhibition zone diameters of 8. 31 mm, 9. 43 mm, respectively. 9. 73 mm, 9. 91 mm, and 11. 33 mm. The ethanol extract of basil leaves has antibacterial activity against Staphylococcus aureus bacteria.
PEMERIKSAAN CEMARAN Escherichia coli, Shigella sp DAN Salmonella sp PADA SUSU SAPI PERAH YANG DIPEROLEH DARI PETERNAKAN ASAM KUMBANG KECAMATAN MEDAN SELAYANG
Authors: Zuhairiah Zuhairiah , Maimunah Siti , Silitonga Maringan
Published: September 2022

Milk is a drink that is mandatory for consumption by the public, especially for children, therefore, milk must be free from contamination with Escherichia coli, Shigella sp and Salmonella sp bacteria, through the tools used are not clean, the environment is dirty, the hands of workers, and others. This study aims to determine the presence or absence of Escherichia coli, Shigella sp, and Salmonella sp bacteria in Dairy Cow Milk obtained from the Asam Kumbang Farm, Medan Selayang District. The research sample was ten samples of milk from dairy cows in one farm with different cows which were treated with two aseptic and non-aseptic treatments. The research method used is descriptive research with MPN (Most Probable Number) method to count coliform bacteria followed by an examination of LB, BGLB, EMBA media, gram staining, biochemical tests, IMVIC tests, and user testing methods on samples of Shigella sp and Salmonella bacteria sp followed by an examination of NB, SCB, SSA media, gram staining, biochemical tests, and IMVIC. The results showed that one aseptic sample A and 3 non-aseptic samples A, B, C had Escherichia coli bacteria in dairy cows' milk. The quality of milk must comply with the requirements of SNI 3141.1:2011 Fresh Milk Quality and the Maximum Limit of Microbial Contamination in SNI 7388-2009 Fresh Milk.
SKRINING FITOKIMIA DAN ANALISIS ALKALOID DARI TUMBUHAN BABAN DOTAN (Ageratum conyzoides L.) DENGAN METODE KROMATOGRAFI LAPIS TIPIS
Authors: Nasution Pandapotan , Silalahi Yosy Cinthya Eriwaty , Marpaung Jon Kenedy , Simatupang Herdison
Published: September 2022

Medicinal plants are a type of plant that partially or completely and the exudate of the plant is used as medicine, medicinal ingredients, or medicinal ingredients. One of the plants that has been used by the community is Baban dotan (Ageratum conyzoides Linn.) which is one of the superior medicinal plants that has multifunctional properties. This study aims to determine the content of compounds contained in the Babandotan plant (Ageratum conyzodes Linn.) and analysis of the alkaloid content using the Thin Layer Chromatography Method. In the phytochemical screening examination of baban dotan (Ageratum conyzoides Linn.) plants. Examination of the analysis of alkaloids using the Thin Layer Chromatography method resulted in the results of the active substances in the Baban dotan plant in the form of alkaloid content separating or being attracted from the focal point and obtained 2 spots that appeared with a brownish yellow color. The results showed that in the phytochemical screening and alkaloid analysis of the Babandotan plant (Ageratum conyzoides Linn.) using the Thin Layer Chromatography method, there were characteristics that could be used to identify the plant.
AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA FLAVONOID DARI TUMBUHAN GENUS ARTOCARPUS SECARA IN SILICO
Authors: Adiansyah Adiansyah , Hutauruk Dumartina , Nainggolan Lastry Derliana
Published: September 2022

The genus Artocarpus is one of the genera of Moraceae plants, this genus consists of 50 species and 40 species of them are found in Indonesia. Several studies have reported that the flavonoid compounds contained in the genus Artocarpus have cytotoxic, antiproliferative, antimalarial, anti-inflammatory, and antioxidant properties. The purpose of this study was to determine the inhibitory activity of the protease enzyme 6LU7 of the SARS-COV-2 virus by flavonoid compounds from plants of the genus Artocarpus using the in-silico tethering method. The method used in the in-silico tethering process is carried out using the PLANTS program, validated using the Yasara program, and visualized using the Moe2008 program. The protein model of the 6LU7 Protease Enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. The results of this study indicate that the binding of flavonoid compounds from the genus Artocarpus to the expression of 6LU7 gives valid results in silico. The flavonoid compounds of the Artocarpus genus inhibited the 6LU7 enzyme protein with a higher docking value than each of the comparison drugs and produced 7 amino acid residues that were bound to each other. The conclusion of this study can be concluded that flavonoid compounds from the genus Artocarpus inhibit the expression of 6LU7 protein with a docking score close to the docking score of each comparison drug and 7 amino acid residues are bound to each other.
PENGGUNAAN EKSTRAK KELOPAK JANTUNG PISANG KEPOK (Musa acuminate L.) DALAM FORMULASI PEWARNA RAMBUT
Authors: Thaib Cut Masyithah , Fitri Raissa , Nurbaya Siti , Simatupang Aprili Yanti
Published: September 2022

Hair dye preparations are cosmetics used in hair makeup to color hair, either to restore the original hair color or change the original hair color to a new color. Kepok banana heart contains dyes and produces anthocyanins which are used as a safe food coloring. The purpose of this study was to determine that the leaf extract of the Kepok banana heart can be formulated as a hair dye and to determine the concentration of the banana flower extract that produces the best color. Kepok banana flower petals were extracted by maceration method using 96% ethanol, then concentrated to obtain Kepok banana flower petals extract. Hair dye preparations were made with a formula consisting of Kepok banana flower petals extract with various concentrations, namely: 2.5%, 5%, 7.5% and 10%. Staining is done by soaking for 1-4 hours. Observation of color stability was carried out by means of a stability test against 15 washings and exposure to the sun for 5 hours on colored hair, and a biological test (irritation). This study showed that the formula made with the extract of the petals of the Kepok banana heart can give a black color. The best staining was obtained from formula C, namely the extract of the petals of the banana heart of the Kepok banana with a concentration of 7.5% which produced a dark black color. The stability test for 15 washes and the stability test against the sunlight for 5 hours showed that there was no discoloration and no irritation to the skin. It can be concluded that Kepok banana flower petal extract can be used as hair dye.
KARAKTERISASI DAN SKRINING FITOKIMIA SERTA ANALISIS FLAVONOID DARI BUAH MENGKUDU (Morindacitrifolia L) SECARA KROMATOGRAFI LAPIS TIPIS
Authors: Sitorus Panal , Suharyanisa Suharyanisa , Chandra Devina , Sitanggang Berton
Published: September 2022

Noni fruit (Morindacitrifolia L.) is a medicinal plant that is well known by the people in Indonesia. Noni is efficacious as an immune enhancer, normalizes blood pressure, anti-cancer, analgesic, diabetes mellitus, heart disease, stroke, antimicrobial. To know the characteristics of simplicia and the class of compounds from the noni fruit as well as to analyze the flavonoid compounds contained in the noni fruit using the thin layer chromatography method. The flavonoid compounds were extracted by maceration using ethanol solvent and then the ethanol extract was tested by thin-layer chromatography using 1% HCl mobile phase and spotting with 1 N H2SO4 reagent and methanol pa (1: 1% v/v). Result of simplicia characterization of fruit Noni, obtained 1.32% water content, 38.41 % water soluble extract content, 16.7% ethanol soluble extract content, 6.09% total ash content, and 0.45 acid insoluble ash content. %. Noni fruit simplicia contains chemical compounds of alkaloids, tannins, flavonoids, triterpenoids/steroids, anthraquinones, saponins with phytochemical screening tests. The value of Rf from the analysis of noni fruit flavonoid compounds using the Thin Layer Chromatography method with 3 repetitions is 0.75; 0.68 and 0.62. This indicates the presence of flavonoid compounds in the noni fruit.
PENGARUH MINYAK KELAPA MURNI DAN MINYAK INTI SAWIT TERHADAP PERTUMBUHAN RAMBUT PADA KELINCI
Authors: Suryani Monica , Surbakti Christica Ilsana , Hadi Novia Silvana
Published: September 2022

Hair is something that comes out of the skin and has a shape like a thin thread. Hair has many things, including protection from the sun's function, adding beauty and color lines to the face, protecting the eyes from sweat, dirt and dust, and others. Hair is composed of a protein substance called keratin. To determine the VCO and PKO in the rate of growth activity and hair distribution rate. Extraction of PKO from palm kernel and VCO from the coconut fruit, characterization testing including fatty acids and squalene using the Gas Chromatography (GC) method, free fatty acids using the titration method with 0.01N KOH, and finally vitamin E using the Ultra Performance Liquid Chromatography (UPLC) method. smeared every 2 times a day. Tests for the distribution rate of hair growth and daily hair growth rate were carried out every 5th, 10th, 15th, 20th, 25th, 30th day. And weight considerations were made on the 30th day. compared to Pure Coconut Oil in hair growth in rabbits.
UJI AKTIVITAS ANTIOKSIDAN SEDIAAN GEL YANG MENGANDUNG EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J. R & G. Forst) DENGAN MENGGUNAKAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl)
Authors: Sidoretno Wahyu Margi , Devitria Rosa , Sepriyani Harni
Published: September 2022

Matoa (Pometia pinnata J.R & J. G. Forster) is one of the plants that can be used for traditional medicine. Based on several studies, it is stated that the ethanolic extract of matoa leaves has good antioxidant activity. This study aims to determine the antioxidant activity of gel preparations from the ethanolic extract of matoa (Pometia pinnata) leaves. Matoa leaf extract (Pometia pinnata) was prepared using maceration method with 96% ethanol as solvent. Then the extract was formulated into a gel with 4 formulations, namely F0 (no matoa leaf extract), FI (with 0.1% matoa leaf ethanol extract), FII (with 0.3% matoa leaf extract), FIII (with ethanol leaf matoa by 0.5%). Furthermore, the antioxidant activity test was carried out on the gel samples using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) spectrophotometrically at a wavelength of 515 nm. The results of the antioxidant activity test showed that the percentage of inhibition of the 96% ethanol extract of matoa leaf (Pometia pinnata) was F0 40.34%, FI 55.187%, FII 61.703%, FIII 27.969%, and the percentage inhibition of vitamin C was 178.947%. So it can be said that the matoa leaf extract gel has antioxidant activity.
UJI AKTIVITAS ANTIBAKTERI DARI BLACK GARLIC DENGAN VARIASI WAKTU BERBEDA TERHADAP Streptococcusmutans PENYEBAB KARIES GIGI
Authors: Purwandari Vivi , Marpaung Jon Kenedy , Suharyanisa Suharyanisa
Published: September 2022

Dental cariesand gingivitis are the two mostcommon dental and oral diseases in human society. The main cause of both diseasesis a collection of bacteria bound in anorganicmatrix and firmlyattachedtothe tooth surface known as plaque. Black garlicis garlic that has been processed by fermentationat a certaintemperaturefor a long time, resulting in new compounds that have pharmacological effects showing broad antibiotic properties against gram-positiveand gram-negative bacteria, includingstrains that are multi-bacterial. Antibiotic resistance. The purpose of this study was to determine the antibacterial activity of black garlic against Streptococcus mutans bacteria and to determine the differences in the variation of the antibacterial fermentation time of blackgarlicon the antibacterial activity of Streptococcus mutans bacteria. The methodused in this study isanexperimentalmethod (experimentalresearch) to determine the effect of blackgarlic as anantibacterial against Streptococcusmutans. The resultsobtained fromthis study are blackgarlic extract containsalkal oids, flavonoids, tannins, andsaponins. Black garlic extract from variations of 7 days, 12 days, 15 days, and Chlorhexidine had an inhibitoryzone with a strong category while steriledistilled water had an inhibitionzone in the weakcategory.
FORMULASI SEDIAAN PEMBUATAN PELEMBAB BIBIR (LIP BALM) MENGGUNAKAN SARI BUAH PEPAYA(Carica papaya L.)
Authors: Supartiningsih Supartiningsih , Maimunah Siti , Sitorus Elly , Lestari Sarah
Published: September 2022

Lip balm adalah sediaan kosmetik perawatan pada bibir yang digunakan untuk melindungi bibir terhadap faktor lingkungan yang merugikan pada keadaan kelembaban udara yang rendah karena suhu yang terlalu dingin, mencegah penguapan air, serta melembabkan bibir agar tidak mudah kering dan pecah- pecah. Tanaman Buah Pepaya (Carica papaya L.) memiliki kandungan antrakuinon, saponin, lignin, glikosida dan tanin. Tujuan penelitian ini adalah untuk memformulasikan dan uji efektifitas sari buah pepaya pada konsentrasi 1%, 5% dan 9% pada sediaan pelembab bibir. Evaluasi sediaan pelembab bibir yaitu uji homogenitas, uji stabilitas, uji oles, uji daya sebar, uji daya lekat. Metode yang dilakukan dalam penelitian ini adalah bersifat eksperimental. Dari hasil penelitian dan pengujian yang telah dilakukan peneliti didapatkan hasil parameter uji daya lekat adalah (Blanko) 1 menit 10 detik, (F1) 1 menit 02 detik, (F2) 57,66 detik, dan (F3) 44,33 detik. Hasil dari pengujian parameter daya sebar memiliki rata-rata 4 cm, 5 cm, 6 cm dan 6 cm. Lip balm yang diformulasi dalam penelitian ini tidak melalui uji iritasi dikarenakan pandemic virus corona yang membuat peneliti tidak bisa menggunakan sukarelawan manusia. Peneliti juga tidak melalui uji kelembapan pada bibir sukarelawan demi menghidari penyebaran virus dan memenuhi protokol kesehatan.
HUBUNGAN RESILIENSI DENGAN COPING STRES PADA KARYAWAN LOTTE Grosir MEDAN
Authors: Meliala Sinarsi , Tobing Laksana , Ningsih Siska Dwi , Nababan Susi Susanti
Published: September 2022

Resilience is the ability where employees can survive and rise in coping with stress. Coping is the ability to overcome self-problems from the demands of stressful situations. This study aims to determine the relationship between resilience and coping for employees of Lotte Grosir Medan. The hypothesis proposed is, there is a positive relationship between resilience and coping with employees. The sample method used is saturated samples, which amounted to 93 people or all employees with work at Lotte Grosir Medan. The measuring instrument used in this study is the scale of resilience and coping. The results of this study found resilience in employees in the high category by 71%. Coping with employees is categorized as high by 51% and the majority of employees use problem focused coping techniques by 57%. Based on the results obtained there is a positive relationship between resilience and coping for employees of Lotte Grosir Medan with a value of rxy = 0.790, meaning that the higher the resilience or ability of employee resilience, the higher the coping of Medan Lotte Wholesale employees in the face of stress.
HUBUNGAN KONSEP DIRI DENGAN MOTIVASI BELAJAR PADA SISWA SMP PANCA ABDI BANGSAKU (PABAKU) STABAT KABUPATEN LANGKAT SUMATERA UTARA
Authors: MELIALA SINARSI
Published: September 2022

Penelitian ini bertujuan untuk mengetahui sejauhmana hubungan konsep diri dengan motivasi belajar pada siswa SMP Panca Abdi Bangsaku Stabat Kabupaten Langkat Sumatera Utara. Hasil uji hipotesis yang menggunakan nilai korelasi antara konsep diri dan motivasi belajar sebesar koefisien korelasi rxy = 0,720 dengan taraf signifikan 0,000 dengan ( p<  0,05). Hal ini menunjukkan hipotesis penelitian yaitu adanya hubungan positif yang signifikan antara konsep diri dengan motivasi belajar artinya semakin tinggi konsep diri pada siswa akan semakin tinggi pula motivasi belajar siswa tersebut. Berdasarkan hasil penelitian yang diperoleh peneliti disimpulkan bahwa motivasi belajar individu dipengaruhi dari dalam diri seseorang tersebut, semakin memiliki konsep diri yang baik maka motivasi belajar  akan terpenuhi.Berdasarkan hasil penelitian, maka hipotesis yang diajukan dalam penelitian ini dinyatakan diterima.Pengambilan data dilakukan disekolah SMP Panca Abdi Bangsaku Stabat Kabupaten Langkat Sumatera Utara. Subjek penelitian adalah siswa-siswi  SMP dengan jumlah sampel sebanyak 70 orang siswa. Teknik pengambilan sampel penelitian ini adalah purposive sampling.