bluuebunny/crossref_metadata_2025 huggingface dataset:
Pseudidiomarina fusca sp. nov., Isolated from the Surface Seawater of the Western Pacific Ocean
Authors: Wang Yaru , Wang Xiaolei , Gao Xueyu , He Jingjing , Yang Xiaoyu , Zhang Yunxiao , Zhang Xiaohua , Shi Xiaochong
Published: February 2024

The Gram-negative marine bacterium GXY010T, which has been isolated from the surface seawater of the western Pacific Ocean, is aerobic, non-motile and non-flagellated. Strain GXY010T exhibits growth across a temperature range of 10–42 °C (optimal at 37 °C), pH tolerance from 7.0 to 11.0 (optimal at 7.5) and a NaCl concentration ranging from 1.0 to 15.0% (w/v, optimal at 5.0%). Ubiquinone-8 (Q-8) was the predominant isoprenoid quinone in strain GXY010T. The dominant fatty acids (>10%) of strain GXY010T were iso-C15:0 (14.65%), summed feature 9 (iso-C17:1 ω9c and/or 10-methyl C16:0) (12.41%), iso-C17:0 (10.85%) and summed feature 3 (C16:1 ω7c and/or C16:1 ω6c) (10.41%). Phosphatidylethanolamine (PE), phosphatidylglycerol (PG), diphosphatidylglycerol (DPG), unidentifiable glycolipid (GL) and four non-identifiable aminolipids (AL1-AL4) were the predominant polar lipids of strain GXY010T. The genomic DNA G+C content was identified as a result of 48.0% for strain GXY010T. The strain GXY010T genome consisted of 2,766,857 bp, with 2664 Open Reading Frames (ORFs), including 2586 Coding sequences (CDSs) and 78 RNAs. Strain GXY010T showed Average Nucleotide Identity (ANI) values of 73.4% and 70.6% and DNA–DNA hybridization (DDH) values of 19.2% and 14.5% with reference species Pseudidiomarina tainanensis MCCC 1A02633T (=PIN1T) and Pseudidiomarina taiwanensis MCCC 1A00163T (=PIT1T). From the results of the polyphasic analysis, a newly named species, Pseudidiomarina fusca sp. nov. within the genus Pseudidiomarina, was proposed. The type strain of Pseudidiomarina fusca is GXY010T (=JCM 35760T = MCCC M28199T = KCTC 92693T).
Possible Role of CHAD Proteins in Copper Resistance
Authors: González-Madrid Gabriela , Navarro Claudio A. , Acevedo-López José , Orellana Luis H. , Jerez Carlos A.
Published: February 2024

Conserved Histidine Alpha-helical Domain (CHAD) proteins attached to the surface of polyphosphate (PolyP) have been studied in some bacteria and one archaeon. However, the activity of CHAD proteins is unknown beyond their interaction with PolyP granules. By using bioinformatic analysis, we report that several species of the biomining acidophilic bacteria contain orthologs of CHAD proteins with high sequence identity. Furthermore, the gene coding for the CHAD protein is in the same genetic context of the enzyme polyphosphate kinase (PPK), which is in charge of PolyP synthesis. Particularly, the group of ppk and CHAD genes is highly conserved. Metallosphaera sedula and other acidophilic archaea used in biomining also contain CHAD proteins. These archaea show high levels of identity in genes coding for a cluster having the same organization. Amongst these genes are chad and ppx. In general, both biomining bacteria and archaea contain high PolyP levels and are highly resistant to heavy metals. Therefore, the presence of this conserved genetic organization suggests a high relevance for their metabolism. It has been formerly reported that a crystallized CHAD protein contains a copper-binding site. Based on this previous knowledge, in the present report, it was determined that all analyzed CHAD proteins are very conserved at their structural level. In addition, it was found that the lack of YgiF, an Escherichia coli CHAD-containing protein, decreases copper resistance in this bacterium. This phenotype was not only complemented by transforming E. coli with YgiF but also by expressing CHAD from Acidithiobacillus ferrooxidans in it. Interestingly, the strains in which the possible copper-binding sites were mutated were also more metal sensitive. Based on these results, we propose that CHAD proteins are involved in copper resistance in microorganisms. These findings are very interesting and may eventually improve biomining operations in the future.
Assessment of Strategies for Preserving Swine Viral RNA Targets in Diagnostic Specimens
Authors: Munguía-Ramírez Berenice , Giménez-Lirola Luis , Zimmerman Jeffrey
Published: February 2024

Successful downstream molecular analyses of viral ribonucleic acid (RNA) in diagnostic laboratories, e.g., reverse transcription-quantitative polymerase chain reaction (RT-qPCR) or next-generation sequencing, are dependent on the quality of the RNA in the specimen. In swine specimens, preserving the integrity of RNA requires proper sample handling at the time the sample is collected on the farm, during transport, and in the laboratory until RNA extraction is performed. Options for proper handling are limited to maintaining the cold chain or using commercial specimen storage matrices. Herein, we reviewed the refereed literature for evidence that commercial specimen storage matrices can play a role in preserving swine viral RNA in clinical specimens. Refereed publications were included if they compared RNA detection in matrix-treated vs. untreated samples. At present, the small number of refereed studies and the inconsistency in reported results preclude the routine use of commercial specimen storage matrices. For example, specimen storage matrices may be useful under specific circumstances, e.g., where it is mandatory to render the virus inactive. In a broader view, statistically sound side-by-side comparisons between specimens, viral RNA targets, and storage conditions are needed to establish if, when, and how commercial specimen storage matrices could be used in diagnostic medicine.
The Raw Material Challenge of Creating a Green Economy
Authors: Herrington Richard Jeremy
Published: February 2024

Clean technologies and infrastructure for our low-carbon, green future carry intense mineral demands. The ambition remains to recycle and reuse as much as we can; however, newly mined resources will be required in the near term despite the massive improvements in the reuse and recycling of existing end-of-use products and wastes. Growth trends suggest that mining will still play a role after 2050 since the demand for metals will increase as the developing world moves toward a per capita usage of materials comparable to that of the developed world. There are sufficient geological resources to deliver the required mineral commodities, but the need to mine must be balanced with the requirement to tackle environmental and social governance issues and to deliver sustainable development goals, ensuring that outcomes are beneficial for both the people and planet. Currently, the lead time to develop new mines following discovery is around 16 years, and this needs to be reduced. New approaches to designing and evaluating mining projects embracing social, biodiversity, and life cycle analysis aspects are pivotal. New frontiers for supply should include neglected mined wastes with recoverable components and unconventional new deposits. New processing technologies that involve less invasive, lower energy and cleaner methodologies need to be explored, and developing such methodologies will benefit from using nature-based solutions like bioprocessing for both mineral recovery and for developing sustainable landscapes post mining. Part of the new ambition would be to seek opportunities for more regulated mining areas in our own backyard, thinking particularly of old mineral districts of Europe, rather than relying on sources with potentially and less controllable, fragile, and problematic supply chains. The current debate about the potential of mining our deep ocean, as an alternative to terrestrial sources needs to be resolved and based on a broader analysis; we can then make balanced societal choices about the metal and mineral supply from the different sources that will be able to deliver the green economy while providing a net-positive deal for the planet and its people.
Fractal Evolution Characteristics of Isolation Layers in a Submarine Gold Mine: A Case Study
Authors: Chen Yin , Li Zijun , Lin Weixing , He Yan , Wang Guoqiang , Ou Renze , Liu Qi
Published: February 2024

The establishment of an isolation layer in submarine mining has been a persistent challenge. In the context of this research, we conducted a similarity simulation test to preliminarily assess the interaction between the thickness and extent of the isolation layer. Subsequently, we introduce an innovative approach that integrates fractal theory and the Bonded Block Model (BBM) to simulate undersea isolation layer mining. The validation of this method relies on on-site borehole scanning and displacement monitoring, which depict the intricate fractal evolution of fractures and predict the optimal thickness of the isolation layer. Our findings affirm the robustness and validity of this method. Evaluation of the fractal dimensions of fractures reveals that a critical threshold of 1.7 is essential to prevent structural failure of the isolation layer, while a limit of 1.5 is necessary to avoid significant water ingress. Remarkably, the correlation dimension of the settlement time series closely aligns with the fractal dimension of the fractures, underscoring the feasibility of ensuring the safety of isolation layer mining through real-time settlement monitoring.
Contact Resistance Sensing for Touch and Squeeze Interactions
Authors: Zhou Nianmei , Devleminck Steven , Geurts Luc
Published: February 2024

This study investigates accessible and sensitive electrode solutions for detecting touches and squeezes on soft interfaces based on commercially available conductive polyurethane foam. Various electrode materials and configurations are explored, and for electrodes made of conductive threads, the static and dynamic electrical behaviors are studied in depth. In contrast to existing approaches that aim to minimize or stabilize contact resistance, we propose leveraging contact resistance to significantly enhance sensing sensitivity. Suggestions for future researchers and developers when building squeeze sensors based on this material are provided. Our findings offer insights for DIY enthusiasts and researchers, enabling them to develop sensitive soft interfaces for touch and squeeze interactions in an affordable and accessible manner and provide a completely soft user experience.
In Vitro Modulation of Spontaneous Activity in Embryonic Cardiomyocytes Cultured on Poly(vinyl alcohol)/Bioglass Type 58S Electrospun Scaffolds
Authors: Rivera-Torres Filiberto , Maciel-Cerda Alfredo , González-Gómez Gertrudis Hortensia , Falcón-Neri Alicia , Gómez-Lizárraga Karla , Esquivel-Posadas Héctor Tomás , Vera-Graziano Ricardo
Published: February 2024

Because of the physiological and cardiac changes associated with cardiovascular disease, tissue engineering can potentially restore the biological functions of cardiac tissue through the fabrication of scaffolds. In the present study, hybrid nanofiber scaffolds of poly (vinyl alcohol) (PVA) and bioglass type 58S (58SiO2-33CaO-9P2O5, Bg) were fabricated, and their effect on the spontaneous activity of chick embryonic cardiomyocytes in vitro was determined. PVA/Bg nanofibers were produced by electrospinning and stabilized by chemical crosslinking with glutaraldehyde. The electrospun scaffolds were analyzed to determine their chemical structure, morphology, and thermal transitions. The crosslinked scaffolds were more stable to degradation in water. A Bg concentration of 25% in the hybrid scaffolds improved thermal stability and decreased degradation in water after PVA crosslinking. Cardiomyocytes showed increased adhesion and contractility in cells seeded on hybrid scaffolds with higher Bg concentrations. In addition, the effect of Ca2+ ions released from the bioglass on the contraction patterns of cultured cardiomyocytes was investigated. The results suggest that the scaffolds with 25% Bg led to a uniform beating frequency that resulted in synchronous contraction patterns.
Ecotoxicological Effects of TiO2 P25 Nanoparticles Aqueous Suspensions on Zebrafish (Danio rerio) Eleutheroembryos
Authors: Ortiz-Román Melissa I. , Casiano-Muñiz Ileska M. , Román-Velázquez Felix R.
Published: February 2024

Among nanoparticles (NPs), titanium dioxide is one of the most highly manufactured worldwide and widely used in multiple products for both industrial use and personal care products. This increases the probability of release into aquatic environments, potentially affecting these ecosystems. The present study aimed to evaluate TiO2 P25 NP toxicity in zebrafish embryos and eleutheroembryos by evaluating LC50, hatching rate, embryo development, and chemical analysis of the TiO2 concentration accumulated in eleutheroembryo tissues. Zebrafish embryos ~2 h post-fertilization (hpf) were exposed to 75, 100, 150, 200, and 250 mg/L TiO2 P25 NPs for 48 and 96 h. A total of 40–60 embryos were placed in each Petri dish for the respective treatments. Three replicates were used for each treatment group. Ti4+ concentrations were determined by inductively coupled plasma optical emission spectrometry (ICP-OES), and a conversion factor was used to calculate the TiO2 concentrations in the tissues. The highest calculated concentrations of TiO2 in zebrafish larvae were 1.0199 mg/L after 48 h and 1.2679 mg/L after 96 h of exposure. The toxicological results indicated that these NPs did not have a significant effect on the mortality and hatching of zebrafish embryos but did have an effect on their development. LC20 and LC30 were determined experimentally, and LC50 and LC80 were estimated using four different methods. Up to 11% of embryos also presented physical malformations. These effects can be detrimental to a species and affect ecosystems. Physical malformations were observed in all treatments, indicating teratogenic effects.
Graphene-Based Tunable Dual-Frequency Terahertz Sensor
Authors: Fu Maixia , Ye Yuchao , Niu Yingying , Guo Shaoshuai , Wang Zhaoying , Liu Xueying
Published: February 2024

A tunable dual-band terahertz sensor based on graphene is proposed. The sensor consists of a metal bottom layer, a middle dielectric layer, and single-layer graphene patterned with four strips on the top. The numerical simulations results show that the proposed sensor exhibits two significant absorption peaks at 2.58 THz and 6.07 THz. The corresponding absorption rates are as high as nearly 100% and 98%, respectively. The corresponding quality factor (Q) value is 11.8 at 2.58 THz and 29.6 at 6.07 THz. By adjusting the external electric field or chemical doping of graphene, the positions of the dual-frequency resonance peak can be dynamically tuned. The excitation of plasma resonance in graphene can illustrate the mechanism of the sensor. To verify the practical application of the device, the terahertz response of different kinds and different thicknesses of the analyte is investigated and analyzed. A phenomenon of obvious frequency shifts of the two resonance peaks can be observed. Therefore, the proposed sensor has great potential applications in terahertz fields, such as material characterization, medical diagnosis, and environmental monitoring.
Interfacial Resistive Switching of Niobium–Titanium Anodic Memristors with Self-Rectifying Capabilities
Authors: Knapic Dominik , Minenkov Alexey , Atanasova Elena , Zrinski Ivana , Hassel Achim Walter , Mardare Andrei Ionut
Published: February 2024

A broad compositional range of Nb-Ti anodic memristors with volatile and self-rectifying behaviour was studied using a combinatorial screening approach. A Nb-Ti thin-film combinatorial library was co-deposited by sputtering, serving as the bottom electrode for the memristive devices. The library, with a compositional spread ranging between 22 and 64 at.% Ti was anodically oxidised, the mixed oxide being the active layer in MIM-type structures completed by Pt discreet top electrode patterning. By studying I–U sweeps, memristors with self-rectifying and volatile behaviour were identified. Moreover, all the analysed memristors demonstrated multilevel properties. The best-performing memristors showed HRS/LRS (high resistive state/low resistive state) ratios between 4 and 6 × 105 and very good retention up to 106 successive readings. The anodic memristors grown along the compositional spread showed very good endurance up to 106 switching cycles, excluding those grown from alloys containing between 31 and 39 at.% Ti, which withstood only 10 switching cycles. Taking into consideration all the parameters studied, the Nb-46 at.% Ti composition was screened as the parent metal alloy composition, leading to the best-performing anodic memristor in this alloy system. The results obtained suggest that memristive behaviour is based on an interfacial non-filamentary type of resistive switching, which is consistent with the performed cross-sectional TEM structural and chemical characterisation.
Terahertz Detection by Asymmetric Dual Grating Gate Bilayer Graphene FETs with Integrated Bowtie Antenna
Authors: Abidi E. , Khan A. , Delgado-Notario J. A. , Clericó V. , Calvo-Gallego J. , Taniguchi T. , Watanabe K. , Otsuji T. , Velázquez J. E. , Meziani Y. M.
Published: February 2024

An asymmetric dual-grating gate bilayer graphene-based field effect transistor (ADGG-GFET) with an integrated bowtie antenna was fabricated and its response as a Terahertz (THz) detector was experimentally investigated. The device was cooled down to 4.5 K, and excited at different frequencies (0.15, 0.3 and 0.6 THz) using a THz solid-state source. The integration of the bowtie antenna allowed to obtain a substantial increase in the photocurrent response (up to 8 nA) of the device at the three studied frequencies as compared to similar transistors lacking the integrated antenna (1 nA). The photocurrent increase was observed for all the studied values of the bias voltage applied to both the top and back gates. Besides the action of the antenna that helps the coupling of THz radiation to the transistor channel, the observed enhancement by nearly one order of magnitude of the photoresponse is also related to the modulation of the hole and electron concentration profiles inside the transistor channel by the bias voltages imposed to the top and back gates. The creation of local n and p regions leads to the formation of homojuctions (np, pn or pp+) along the channel that strongly affects the overall photoresponse of the detector. Additionally, the bias of both back and top gates could induce an opening of the gap of the bilayer graphene channel that would also contribute to the photocurrent.
Porous Carbon Interlayer Derived from Traditional Korean Paper for Li–S Batteries
Authors: Choi Yunju , Jang Hyungil , Kim Jong-Pil , Lee Jaeyeong , Jeong Euh Duck , Bae Jong-Seong , Shin Heon-Cheol
Published: February 2024

A carbonized interlayer effectively helps to improve the electrochemical performance of lithium–sulfur (Li–S) batteries. In this study, a simple and inexpensive carbon intermediate layer was fabricated using a traditional Korean paper called “hanji”. This carbon interlayer has a fibrous porous structure, with a specific surface area of 91.82 m2 g−1 and a BJH adsorption average pore diameter of 26.63 nm. The prepared carbon interlayer was utilized as an intermediary layer in Li–S batteries to decrease the charge-transfer resistance and capture dissolved lithium polysulfides. The porous fiber-shaped carbon interlayer suppressed the migration of polysulfides produced during the electrochemical process. The carbon interlayer facilitates the adsorption of soluble lithium polysulfides, allowing for their re-utilization in subsequent cycles. Additionally, the carbon interlayer significantly reduces the polarization of the cell. This simple strategy results in a significant improvement in cycle performance. Consequently, the discharge capacity at 0.5 C after 150 cycles was confirmed to have improved by more than twofold, reaching 230 mAh g−1 for cells without the interlayer and 583 mAh g−1 for cells with the interlayer. This study demonstrates a simple method for improving the capacity of Li–S batteries by integrating a functional carbon interlayer.
Outlining the Phytoconstituents of Greek Clover Herb Extract and Assessment of Its Effect against Foodborne Infections Caused by Salmonella typhimurium
Authors: Alqahtani Jawaher , Negm Walaa A. , Elekhnawy Engy , Alqahtani Moneerah J. , Moglad Ehssan , Ibrahim Sarah , El-Sherbeni Suzy A.
Published: February 2024

Owing to the spread of resistance between pathogenic bacteria, searching for novel compounds with antibacterial activity is essential. Here, we investigated the potential antibacterial activity of Greek clover or Trigonella foenum-graecum herb extract on Salmonella typhimurium clinical isolates. The chemical profile of the herb was initially determined using LC-ESI-MS/MS, which explored 36 different compounds. Interestingly, the fenugreek extract possessed antibacterial action in vitro with minimum inhibitory concentrations of 64 to 512 µg/mL. The potential mechanism of action was studied by elucidating the effect of the fenugreek extract on the membrane properties of S. typhimurium bacteria, including the inner and outer membrane permeability and membrane integrity. Remarkably, the fenugreek extract had detrimental effects on the membrane properties in 40–60% of the isolates. Moreover, the in vivo antibacterial action was studied using a gastrointestinal infection model with S. typhimurium bacteria. Interestingly, the fenugreek extract (200 mg/kg) improved the infection outcomes in the tested mice. This was represented by the noteworthy decrease (p < 0.05) in the bacterial count in the small intestine and caecum tissues. The survival rate of the fenugreek-extract-treated mice significantly increased compared to the S. typhimurium-infected group. Additionally, there was an improvement in the histological and immunohistochemical features of tumor necrosis factor-alpha. In addition, using an ELISA and qRT-PCR, there was an improvement in the proinflammatory and oxidative stress markers in the fenugreek-extract-treated group. Consequently, fenugreek extract should be investigated further on other food pathogens.
Shaping the Future of Obesity Treatment: In Silico Multi-Modeling of IP6K1 Inhibitors for Obesity and Metabolic Dysfunction
Authors: Mondal Ismail , Halder Amit Kumar , Pattanayak Nirupam , Mandal Sudip Kumar , Cordeiro Maria Natalia D. S.
Published: February 2024

Recent research has uncovered a promising approach to addressing the growing global health concern of obesity and related disorders. The inhibition of inositol hexakisphosphate kinase 1 (IP6K1) has emerged as a potential therapeutic strategy. This study employs multiple ligand-based in silico modeling techniques to investigate the structural requirements for benzisoxazole derivatives as IP6K1 inhibitors. Firstly, we developed linear 2D Quantitative Structure–Activity Relationship (2D-QSAR) models to ensure both their mechanistic interpretability and predictive accuracy. Then, ligand-based pharmacophore modeling was performed to identify the essential features responsible for the compounds’ high activity. To gain insights into the 3D requirements for enhanced potency against the IP6K1 enzyme, we employed multiple alignment techniques to set up 3D-QSAR models. Given the absence of an available X-ray crystal structure for IP6K1, a reliable homology model for the enzyme was developed and structurally validated in order to perform structure-based analyses on the selected dataset compounds. Finally, molecular dynamic simulations, using the docked poses of these compounds, provided further insights. Our findings consistently supported the mechanistic interpretations derived from both ligand-based and structure-based analyses. This study offers valuable guidance on the design of novel IP6K1 inhibitors. Importantly, our work exclusively relies on non-commercial software packages, ensuring accessibility for reproducing the reported models.
Mesenchymal Stem Cell (MSC)-Based Drug Delivery into the Brain across the Blood–Brain Barrier
Authors: Tashima Toshihiko
Published: February 2024

At present, stem cell-based therapies using induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) are being used to explore the potential for regenerative medicine in the treatment of various diseases, owing to their ability for multilineage differentiation. Interestingly, MSCs are employed not only in regenerative medicine, but also as carriers for drug delivery, homing to target sites in injured or damaged tissues including the brain by crossing the blood–brain barrier (BBB). In drug research and development, membrane impermeability is a serious problem. The development of central nervous system drugs for the treatment of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, remains difficult due to impermeability in capillary endothelial cells at the BBB, in addition to their complicated pathogenesis and pathology. Thus, intravenously or intraarterially administered MSC-mediated drug delivery in a non-invasive way is a solution to this transendothelial problem at the BBB. Substances delivered by MSCs are divided into artificially included materials in advance, such as low molecular weight compounds including doxorubicin, and expected protein expression products of genetic modification, such as interleukins. After internalizing into the brain through the fenestration between the capillary endothelial cells, MSCs release their cargos to the injured brain cells. In this review, I introduce the potential and advantages of drug delivery into the brain across the BBB using MSCs as a carrier that moves into the brain as if they acted of their own will.
A Review of Olanzapine in the Treatment of Cancer Anorexia-Cachexia Syndrome
Authors: Poon Ivy O. , Ajewole Veronica , Braun Ursula K.
Published: February 2024

Background: Cancer anorexia-cachexia syndrome (CAS) is a multifactorial condition that is highly prevalent in advanced cancer patients and associated with significant reduction in functional performance, reduction in quality of life, and increased mortality. Currently, no medications are approved for this indication. Recently, the American Society of Clinical Oncology (ASCO) released a rapid recommendation suggesting that low-dose olanzapine once daily may be used to treat cancer cachexia. Many questions still exist on how to use olanzapine for this indication in clinical practice. The objective of this review is to identify existing knowledge on the use of olanzapine for CAS. Methods: A comprehensive search was conducted to identify the primary literature that involved olanzapine for anorexia and cachexia in cancer patients between 2000 and 2023. Results: Seven articles were identified and are discussed here, including two randomized double-blinded placebo-controlled studies, one randomized comparative study, two prospective open-label studies, one retrospective chart review, and one case report. Conclusions: Low dose olanzapine (2.5–5 mg once daily) may be useful in the treatment of CAS for increasing appetite, reducing nausea and vomiting, and promoting weight gain. Further large-scale multi-center randomized placebo-controlled studies will be needed to investigate the impact of olanzapine on weight change in CAS patients.
How Intuitive Is the Administration of Pediatric Emergency Medication Devices for Parents? Objective Observation and Subjective Self-Assessment
Authors: Müller Ruth Melinda , Herziger Birthe , Jeschke Sarah , Neininger Martina Patrizia , Bertsche Thilo , Bertsche Astrid
Published: February 2024

Background: to assess the intuitiveness of parents’ administration of pediatric emergency devices (inhalation, rectal, buccal, nasal, and auto-injector). Methods: We invited parents without prior experience to administer the five devices to dummy dolls. We observed whether the parents chose the correct administration route and subsequently performed the correct administration procedures without clinically relevant errors. We interviewed parents for their self-assessment of their own administration performance and willingness to administer devices in actual emergencies. Results: The correct administration route was best for the inhalation device (81/84, 96% of parents) and worst for the intranasal device (25/126, 20%). The correct administration procedures were best for the buccal device (63/98, 64%) and worst for the auto-injector device (0/93, 0%). Their own administration performance was rated to be best by parents for the inhalation device (59/84, 70%) and worst for the auto-injector device (17/93, 18%). The self-assessment of the correct administration overestimated the correct administration procedures for all the devices except the buccal one. Most parents were willing to administer the inhalation device in an emergency (67/94, 79%), while the fewest were willing to administration procedures the auto-injector device (28/93, 30%). Conclusions: Intuitiveness concerning the correct administration route and the subsequent correct administration procedures have to be improved for all the devices examined. The parents mostly overestimated their performance. Willingness to use a device in an actual emergency depended on the device.
Two Cases of Vancomycin-Induced Neutropenia
Authors: Ganaja Kirsten , Scoular Sarah , Hemmer Staci
Published: February 2024

(1) Background: The incidence of vancomycin-induced neutropenia in hospitalized patients is estimated to be around 2 to 8 percent Data surrounding vancomycin-induced neutropenia is limited as it is based on a small number of observational case reports. Additionally, it is difficult to provide generalized conclusions since patient characteristics and indications for treatment vary between reports. (2) Case Reports: We present two cases of vancomycin-induced neutropenia that occurred at our facility; a 50-year-old male who developed neutropenia after treatment with vancomycin for a gluteal abscess and a 51-year-old female who developed neutropenia after treatment with vancomycin for lumbar osteomyelitis. In both cases, neutropenia resolved within 2 days of discontinuation of vancomycin. (3) Conclusions: Vancomycin-induced neutropenia is thought to be a relatively uncommon adverse drug reaction. These two cases of neutropenia likely caused by prolonged exposure to vancomycin occurred at our facility within 3 months of each other. Additional studies are needed to better understand the true incidence of this adverse drug reaction and to identify risk factors that may predispose patients to vancomycin-induced neutropenia.
Enhancing Dynamic Performance in K-Rb-21Ne Co-Magnetometers through Atomic Density Optimization
Authors: Yang Lv , Pang Haoying , Quan Wei
Published: February 2024

The K-Rb-21Ne co-magnetometer exhibits poorer dynamic performance due to the larger equivalent magnetic field generated by alkali metal atoms. In this study, the impact of the atomic number density of alkali metal atoms and noble gas atoms in the cell on the dynamic performance of the atomic ensemble is investigated quantitatively. Relationships between the slow-decay term in the transient response attenuation of the Spin-Exchange Relaxation-Free (SERF) co-magnetometer to interference magnetic fields and the number densities of noble gas atoms as well as alkali metal atoms are established. Based on the established model, the relationship between the number density of 21Ne atoms and dynamic performance is investigated using cells with five different noble gas pressures. Then, we investigate the impact of the number density of alkali metal atoms using a cell with a pressure of 2.1 atm at different temperatures. The results indicate that, as the number density of alkali metal atoms or noble gas atoms in the cell increases, the dynamic performance of the system improves, which provides a theoretical basis for the design of cell parameters for SERF co-magnetometers.
High Electric Field Enhancement Induced by Modal Coupling for a Plasmonic Dimer Array on a Metallic Film
Authors: Liu Jiawei , Meng Ziming , Zhou Jinyun
Published: February 2024

A giant electric field on a subwavelength scale is highly beneficial for boosting the light–matter interaction. In this paper, we investigated a hybrid structure consisting of a hemispheric dimer array and a gold film and realized resonant mode coupling of the surface lattice resonance (SLR) and surface plasmon polariton (SPP). Mode coupling is demonstrated by observing anti-crossing in reflection spectra, which corresponds to Rabi splitting. Although the resonance coupling does not enter the strong coupling regime, an improved quality factor (Q~350) and stronger electric field enhancement in the gap region of the dimer (i.e., hot spot) in our hybrid structure are obtained compared to those of the single dimer or dimer array only. Remarkably, the magnitude of electric field enhancement over 500 can be accessible. Such high field enhancement makes our hybridized structure a versatile platform for the realization of ultra-sensitive biosensing, low-threshold nanolasing, low-power nonlinear optical devices, etc.
Design and Analysis of Optomechanical Micro-Gyroscope for Angular-Vibration Detection
Authors: Hassan Jamal N. A. , Huang Wenyi , Yan Xing , Zhang Senyu , Chen Dingwei , Wen Guangjun , Huang Yongjun
Published: February 2024

Micro-gyroscopes based on the Coriolis principle are widely employed in inertial navigation, motion control, and vibration analysis applications. Conventional micro-gyroscopes often exhibit limitations, including elevated noise levels and suboptimal performance metrics. Conversely, the advent of cavity optomechanical system technology heralds an innovative approach to micro-gyroscope development. This method enhances the device’s capabilities, offering elevated sensitivity, augmented precision, and superior resolution. This paper presents our main contributions which include a novel dual-frame optomechanical gyroscope, a unique photonic crystal cavity design, and advanced numerical simulation and optimization methods. The proposed design utilizes an optical cavity formed between dual oscillating frames, whereby input rotation induces a measurable phase shift via optomechanical coupling. Actuation of the frames is achieved electrostatically via an interdigitated comb-drive design. Through theoretical modeling based on cavity optomechanics and finite element simulation, the operating principle and performance parameters are evaluated in detail. The results indicate an expected angular rate sensitivity of 22.8 mV/°/s and an angle random walk of 7.1 × 10−5 °/h1/2, representing superior precision to existing micro-electromechanical systems gyroscopes of comparable scale. Detailed analysis of the optomechanical transduction mechanism suggests this dual-frame approach could enable angular vibration detection with resolution exceeding state-of-the-art solutions.
Solid-State Color Centers for Single-Photon Generation
Authors: Andrini Greta , Amanti Francesco , Armani Fabrizio , Bellani Vittorio , Bonaiuto Vincenzo , Cammarata Simone , Campostrini Matteo , Dao Thu Ha , De Matteis Fabio , Demontis Valeria , Di Giuseppe Giovanni , Ditalia Tchernij Sviatoslav , Donati Simone , Fontana Andrea , Forneris Jacopo , Francini Roberto , Frontini Luca , Gunnella Roberto , Iadanza Simone , Kaplan Ali Emre , Lacava Cosimo , Liberali Valentino , Marzioni Francesco , Nieto Hernández Elena , Pedreschi Elena , Piergentili Paolo , Prete Domenic , Prosposito Paolo , Rigato Valentino , Roncolato Carlo , Rossella Francesco , Salamon Andrea , Salvato Matteo , Sargeni Fausto , Shojaii Jafar , Spinella Franco , Stabile Alberto , Toncelli Alessandra , Trucco Gabriella , Vitali Valerio
Published: February 2024

Single-photon sources are important for integrated photonics and quantum technologies, and can be used in quantum key distribution, quantum computing, and sensing. Color centers in the solid state are a promising candidate for the development of the next generation of single-photon sources integrated in quantum photonics devices. They are point defects in a crystal lattice that absorb and emit light at given wavelengths and can emit single photons with high efficiency. The landscape of color centers has changed abruptly in recent years, with the identification of a wider set of color centers and the emergence of new solid-state platforms for room-temperature single-photon generation. This review discusses the emerging material platforms hosting single-photon-emitting color centers, with an emphasis on their potential for the development of integrated optical circuits for quantum photonics.
Numerical Simulation and Experimental Investigation of ps Pulsed Laser Modification inside 4H-SiC Material
Authors: Song Yiying , Zhao Shusen , He Hongzhi , Liang Han , Dai Zhanfeng , Lin Xuechun , Zhang Guling
Published: February 2024

Silicon Carbide (SiC) is the predominant substrate material for optoelectronic-integrated devices. However, it challenges the wafer-slicing process because of its high hardness, brittleness, and other material characteristics. Laser processing has gained prominence as the primary method, leveraging its merits of high efficiency, precision, and micro-destructiveness. In this study, a finite element method is applied to calculate the temperature field distribution resulting from the electric field of a Gaussian beam. The simulation considers laser propagation inside 4H-SiC, non-linear absorption, and spherical aberration induced by the refractive index of the material. The influence of laser pulse energy and focusing depth are considered. The results indicate that the modification depths decrease with the increasing focusing depth. With the increase of laser pulse energy, the depth of the modification layer increases continuously. Moreover, an experimental setup has been devised to furnish valuable references in validating the proposed model.
Dark Light Image-Enhancement Method Based on Multiple Self-Encoding Prior Collaborative Constraints
Authors: Guan Lei , Dong Jiawei , Li Qianxi , Huang Jijiang , Chen Weining , Wang Hao
Published: February 2024

The purpose of dark image enhancement is to restore dark images to visual images under normal lighting conditions. Due to the ill-posedness of the enhancement process, previous enhancement algorithms often have overexposure, underexposure, noise increases and artifacts when dealing with complex and changeable images, and the robustness is poor. This article proposes a new enhancement approach consisting in constructing a dim light enhancement network with more robustness and rich detail features through the collaborative constraint of multiple self-coding priors (CCMP). Specifically, our model consists of two prior modules and an enhancement module. The former learns the feature distribution of the dark light image under normal exposure as an a priori term of the enhancement process through multiple specific autoencoders, implicitly measures the enhancement quality and drives the network to approach the truth value. The latter fits the curve mapping of the enhancement process as a fidelity term to restore global illumination and local details. Through experiments, we concluded that the new method proposed in this article can achieve more excellent quantitative and qualitative results, improve detail contrast, reduce artifacts and noise, and is suitable for dark light enhancement in multiple scenes.
An Optimal Model for Determination Shut-In Time Post-Hydraulic Fracturing of Shale Gas Wells: Model, Validation, and Application
Authors: Li Jianmin , Tian Gang , Chen Xi , Xie Bobo , Zhang Xin , Teng Jinchi , Zhao Zhihong , Jin Haozeng
Published: February 2024

The global shale gas resources are huge and have good development prospects, but shale is mainly composed of nanoscale pores, which have the characteristics of low porosity and low permeability. Horizontal drilling and volume fracturing techniques have become the effective means for developing the shale reservoirs. However, a large amount of mining data indicate that the fracturing fluid trapped in the reservoir will inevitably cause hydration interaction between water and rock. On the one hand, the intrusion of fracturing fluid into the formation causes cracks to expand, which is conducive to the formation of complex fracture networks; on the other hand, the intrusion of fracturing fluid into the formation causes the volume expansion of clay minerals, resulting in liquid-phase trap damage. At present, the determination of well closure time is mainly based on experience without theoretical guidance. Therefore, how to effectively play the positive role of shale hydration while minimizing its negative effects is the key to optimizing the well closure time after fracturing. This paper first analyzes the shale pore characteristics of organic pores, clay pores, and brittle mineral pores, and the multi-pore self-absorption model of shale is established. Then, combined with the distribution characteristics of shale hydraulic fracturing fluid in the reservoir, the calculation model of backflow rate and shut-in time is established. Finally, the model is validated and applied with an experiment and example well. The research results show that the self-imbibition rate increases with the increase in self-imbibition time, and the flowback rate decreases with the increase in self-imbibition time. The self-imbibition of slick water is the maximum, the self-imbibition of breaking fluid is the minimum, and the self-imbibition of mixed fluid is the middle, and the backflow rates of these three liquids are in reverse order. It is recommended the shut-in time of Longmaxi Formation shale is 17 days according to the hydration and infiltration model.
Effect of Composite Interface Enhancer on the Cementation Strength of Shale Formation–Cement Ring Interface
Authors: Tian Hui , Liu Huajie , Bu Yuhuan , Chen Zihan , Guo Shenglai
Published: February 2024

The cement strength between the cement and the formation is a key factor in determining the cementation sealing capacity. In the shale formation, due to the organic matter content, the cementing quality between the formation and the cement ring is poor, which affects the quality of cementing. It is easy to cause problems such as annulus pressure. To improve the quality of cementing, this paper investigates the effect of amino silane coupling agents, vinyl silane coupling agents and aluminium–zirconate coupling agents on the interface cementation of rock and cement under different conditions. Meanwhile, the effects of different coupling agent compounding on improving the cementation interface cement strength under different temperature and concentration conditions were investigated. This led to the development of a composite interface enhancer. The composite interface enhancer can improve the bond strength between cement and rock by 189.22%. A preflush fluid system was developed to effectively improve the cementation strength of mud shale formations, and its performance was evaluated. The density of the preflush fluid system is 1.15 g·cm−3, and it has good rheology, settlement stability, and filtration loss. In addition, it improves the cementing interface cementing strength between the cement and shale formation.
Chaos-Enhanced Archimede Algorithm for Global Optimization of Real-World Engineering Problems and Signal Feature Extraction
Authors: Bencherqui Ahmed , Tahiri Mohamed Amine , Karmouni Hicham , Alfidi Mohammed , El Afou Youssef , Qjidaa Hassan , Sayyouri Mhamed
Published: February 2024

Optimization algorithms play a crucial role in a wide range of fields, from designing complex systems to solving mathematical and engineering problems. However, these algorithms frequently face major challenges, such as convergence to local optima, which limits their ability to find global, optimal solutions. To overcome these challenges, it has become imperative to explore more efficient approaches by incorporating chaotic maps within these original algorithms. Incorporating chaotic variables into the search process offers notable advantages, including the ability to avoid local minima, diversify the search, and accelerate convergence toward optimal solutions. In this study, we propose an improved Archimedean optimization algorithm called Chaotic_AO (CAO), based on the use of ten distinct chaotic maps to replace pseudorandom sequences in the three essential components of the classical Archimedean optimization algorithm: initialization, density and volume update, and position update. This improvement aims to achieve a more appropriate balance between the exploitation and exploration phases, offering a greater likelihood of discovering global solutions. CAO performance was extensively validated through the exploration of three distinct groups of problems. The first group, made up of twenty-three benchmark functions, served as an initial reference. Group 2 comprises three crucial engineering problems: the design of a welded beam, the modeling of a spring subjected to tension/compression stresses, and the planning of pressurized tanks. Finally, the third group of problems is dedicated to evaluating the efficiency of the CAO algorithm in the field of signal reconstruction, as well as 2D and 3D medical images. The results obtained from these in-depth tests revealed the efficiency and reliability of the CAO algorithm in terms of convergence speeds, and outstanding solution quality in most of the cases studied.
DEM Investigation on the Flow and Heat Transmission Characteristics of Multi-Size Particles Mixed Flow in Moving Bed
Authors: Cao Wenbo , Zhang Fengxia , Hu Jianhang , Yang Shiliang , Liu Huili , Wang Hua
Published: February 2024

The moving bed heat exchanger (MBHE) has been widely applied in the recovery of waste heat of industrial particles. Currently, investigations focus on uniform-size particles in the MBHE, but few studies are conducted on multi-size particles produced by industrial granulation. Therefore, based on the discrete element method (DEM), the heat transmission model of multi-size particles is established, and flow and heat transmission processes of typically normal distribution particles in the MBHE are studied. In conclusion, there are significant differences in particles tangential velocity and contact number in local regions of a heat exchanger pipe, resulting in different local heat transmission coefficients. In addition, the increases in outlet particle velocity and inlet particle temperature significantly enhance the heat transmission. When the outlet particle velocity grows from 1 mm/s to 5 mm/s, the overall heat transmission coefficient increases by 36.4%, and as the inlet particle temperature rises from 473 K to 873 K, the overall heat transmission coefficient increases by 16.1%.
The Power of Preaching and Deliberative Dialogue to Catalyze Congregational Social Action: A Case Study from “The Purple Zone”
Authors: Schade Leah D.
Published: February 2024

This article explores different ways that preachers and congregations have used the sermon-dialogue-sermon process to address social issues in their churches and engage their local community. I begin with a brief review of the homiletic theory behind the emergence of dialogical preaching, including the ways I have integrated this theory into my own method of the sermon-dialogue-sermon (SDS) process. I then explain the work I have performed training preachers and congregations in the SDS method. This article then focuses on the Rev. Dr. Stephanie Moon, a pastor in Kentucky who undertook the SDS process with her congregation, North Middletown Christian Church (Disciples of Christ), in Middletown, Kentucky. Their work allows for a longitudinal case study of the ways in which the SDS process can assist a congregation in engaging and strengthening democratic practices through deliberation and community outreach. The article concludes with a reflection on the implications of this process for a congregation’s engagement with social issues as well as recommendations for further research and analysis.