bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Method for Determining Standard Enthalpy and Entropy of Volatilisation of Chromia Exposed to Humidified Oxygen at 298 K Based on Transport Theory of Multicomponent Gas Mixtures
Authors: Thublaor Thammaporn , Tengprasert Watcharapon , Suparapinyopapkul Grid , Nilsonthi Thanasak , Chandra-ambhorn Walairat , Chandra-ambhorn Somrerk
Published: January 2025

Based on the transport theory of multicomponent gas mixtures, we proposed an expression for determining the standard volatilisation enthalpy and entropy of chromia exposed to humidified oxygen at 298 K. The use of this expression could lead to the quantification of those thermodynamic quantities when the mass flux of Cr loss due to the volatilisation of chromia is determined. We thus experimentally measured the mass fluxes of Cr loss due to volatilisation in humidified atmospheres at 873–1073 K. As a result, the standard enthalpy and entropy of the volatilisation of chromia subjected to humidified oxygen at 298 K were quantified, giving the values of 61.1 ± 1.0 kJ mol−1 and −43.0 ± 1.9 J K−1 mol−1, respectively. The measured and calculated mass fluxes of Cr loss due to volatilisation tended to be related to absolute temperature in the Arrhenius-like form. We proposed the use of the line of the mass flux of Cr loss due to volatilisation in an Arrhenius-like diagram, which was shifted by the different thermodynamic data used to graphically assess the reliability of the thermodynamic data obtained from this work and the literature.
Real-Time Detection of Smoke and Fire in the Wild Using Unmanned Aerial Vehicle Remote Sensing Imagery
Authors: Fan Xijian , Lei Fan , Yang Kun
Published: January 2025

Detecting wildfires and smoke is essential for safeguarding forest ecosystems and offers critical information for the early evaluation and prevention of such incidents. The advancement of unmanned aerial vehicle (UAV) remote sensing has further enhanced the detection of wildfires and smoke, which enables rapid and accurate identification. This paper presents an integrated one-stage object detection framework designed for the simultaneous identification of wildfires and smoke in UAV imagery. By leveraging mixed data augmentation techniques, the framework enriches the dataset with small targets to enhance its detection performance for small wildfires and smoke targets. A novel backbone enhancement strategy, integrating region convolution and feature refinement modules, is developed to facilitate the ability to localize smoke features with high transparency within complex backgrounds. By integrating the shape aware loss function, the proposed framework enables the effective capture of irregularly shaped smoke and fire targets with complex edges, facilitating the accurate identification and localization of wildfires and smoke. Experiments conducted on a UAV remote sensing dataset demonstrate that the proposed framework achieves a promising detection performance in terms of both accuracy and speed. The proposed framework attains a mean Average Precision (mAP) of 79.28%, an F1 score of 76.14%, and a processing speed of 8.98 frames per second (FPS). These results reflect increases of 4.27%, 1.96%, and 0.16 FPS compared to the YOLOv10 model. Ablation studies further validate that the incorporation of mixed data augmentation, feature refinement models, and shape aware loss results in substantial improvements over the YOLOv10 model. The findings highlight the framework’s capability to rapidly and effectively identify wildfires and smoke using UAV imagery, thereby providing a valuable foundation for proactive forest fire prevention measures.
Finite-Time Stability Analysis for Delayed Fuzzy Hadamard Fractional-Order Systems
Authors: Gassara Hamdi , Tlija Mehdi , Mchiri Lassaad , Ben Makhlouf Abdellatif
Published: January 2025

This paper focuses on the Finite-Time Stability Analysis (FTSA) problem for a Hadamard fractional-order system with time delay represented by a Delayed Takagi–Sugeno Fuzzy Model (DTSFM). Based on the Linear Matrix Inequality (LMI) approach, we propose two methods for FTSA. The first procedure is accomplished in two steps, while the second one is provided in only one step. The proposed results are extended to the case of DTSFM with uncertainties. An example is proposed to validate these results and to demonstrate the advantages of the one-step results compared to the two-step procedure.
Enhancement of the Precision ID Mitochondrial DNA Whole Genome System for Challenging Unidentified Human Remains
Authors: Canale Lauren C. , Date-Chong Mavis , Wallin Jeanette , Sheehan Sandra , Battaglia Jessica , Halsing Michelle , Cuenca Daniela
Published: January 2025

Background: The Precision ID mitochondrial (mt) DNA Whole Genome system is a fully automated massively parallel sequencing (MPS) solution for the whole mitochondrial genome. While extremely sensitive, the Precision ID system is susceptible to inhibitors and microbial DNA that are often co-extracted from human remains. Methods: DNA templates spiked with varying amounts of hematin, humic acid, and calcium, along with bones containing degraded and non-human DNA, were sequenced using the Precision ID system with and without the addition of bovine serum albumin (BSA). Results: BSA added to the initial PCR reaction successfully improved the robustness of the Precision ID system while not negatively impacting the sequencing success of uninhibited samples. The success of BSA is inhibitor-concentration dependent and is effective for templates containing at least 50 ng/μL humic acid, 50 μM hematin, and 1500 μM calcium ions. Furthermore, the presence of microbial DNA in addition to an inhibitor, results in non-specific adaptor ligation to the non-human DNA; BSA can alleviate the inhibition, allowing the human mtDNA to be amplified and sequenced. Conclusions: The addition of BSA to the Precision ID mtDNA system can yield successful sequencing results from challenging case samples that would otherwise fail.
Genome-Wide Identification and Characterization of the Pirin Gene Family in Nicotiana benthamiana
Authors: Xu Gecheng , Shi Jingjing , Qiao Jiliang , Liao Pingan , Yong Bin , Zhong Kaili
Published: January 2025

Background: Pirins are nuclear cupin proteins, one of several gene families within the plant cupin superfamily. However, the identification and functional analysis of Pirin proteins in Nicotiana benthamiana have not been explored. Methods: In this study, genome-wide analysis identifying NbPirin genes in N. benthamiana was conducted, as was phylogenetic analysis of Pirin genes in four Solanaceae species (including Capsicum annuum, Solanum lycopersicum, Solanum tuberosum, and N. benthamiana). In addition, we also evaluated the expression pattern of NbPirins under abiotic stress (temperature and phytohormones) and biotic stress (TMV, TuMV, and PVX). Results: A total of six Nbpirin genes were identified, which can be divided into three clades, and NbPirins also embraced a variety of abiotic or biotic cis-acting elements. The results showed that the expression of NbPirin1-6 was influenced by temperature variations, of which NbPirin6 was significantly upregulated at high temperatures (42 °C) but downregulated at low temperatures (4 °C). Notably, the expression of NbPirin6 exhibited a consistent decrease under ABA and MeJA treatments. Moreover, the expression of NbPirin1-6 was also affected by TMV, TuMV, and PVX infection. NbPirin1, NbPirin2, NbPirin3, and NbPirin5 showed higher expression levels under different viral infections compared to non-infection. Interestingly, NbPirin3 showed the highest expression level during TuMV infection (approximately a 20-fold increase compared to non-infection). Conclusions: Our study proposes the potential role of NbPirin6 in plant responses to abiotic stress, and the role of NbPirin3 in plant antiviral defense, and further lays the groundwork for future research on the functions of NbPirin proteins in responses to various stressors.
Genetic and Haplotype Diversity of Hoplolaimus (Nematoda: Hoplolaimidae) Through Analysis of COI of mtDNA
Authors: Shokoohi Ebrahim , Masoko Peter
Published: January 2025

Lance nematodes (Hoplolaimus spp.) feed on the roots of various plants, including key horticultural products. An investigation of the genetic diversity and structure of six Hoplolaimus species, utilizing the cytochrome c oxidase I (COI) of the mtDNA gene, was based on 174 sequences available on the NCBI. Based on the COI of mtDNA, the haplotype analysis revealed 44 haplotypes. Nucleotide diversity was low among all species of Hoplolaimus, except for H. magnistylus (π = 0.04915) and H. stephanus (π = 0.06746). In contrast, haplotype diversity (Hd) was high, especially for H. stephanus (Hd = 0.89) and H. pararobustus (Hd = 0.90). Phylogenetic analysis grouped the various populations into eight clades, and the result showed that H. magnistylus was placed in three different clades, which showed high variability in haplotype supported by the haplotype network. Neutrality tests and mismatch distribution based on the mtDNA supported the hypothesis of a constant population with no expansion in Hoplolaimus, except for H. concaudajuvencus (Tajima (D) = −0.84971) and H. columbus (Tajima (D) = −0.87674). In conclusion, genetic analysis showed a neutral evolution amongst the Hoplolaimus species. The result of the present study provides a better insight into the Hoplolaimus species toward species delimitation and managing this plant-parasitic nematode in various crops.
Chronic Kidney Disease in Balkan Countries—A Call for Optimal Multidisciplinary Management
Authors: Laganović Mario , Naumović Radomir , Nikolova Milena , Petrov Petar , Radić Josipa , Mitić Igor , Marn Pernat Andreja
Published: January 2025

The treatment of chronic kidney disease (CKD) has been considerably transformed in the last couple of years. However, effective management of patients with CKD is still not achieved, despite clear guidelines promoting active screening of high-risk patients, immediate diagnosis based on laboratory markers, and early initiation or intensification of pharmacotherapy like sodium/glucose cotransporter 2 (SGLT2) inhibitors, which showed reliable results in preventing disease progression, complications, and mortality. Following a recent initiative on early diagnosis, nephrology experts from Bulgaria, Croatia, Serbia, and Slovenia discussed the challenges and opportunities related to CKD treatment in the Balkan countries, also reflecting on the heterogenous socio-economic context of the region. The ongoing education of all stakeholders involved in kidney care, structured support for primary care providers, and the improvement of multidisciplinary networks were consistently recognized as key success factors. Optimal CKD management is based on continuity of care and the timely transition of coordination from primary care to nephrology-specialized services.
Dynamics of Intestinal Mucosa Microbiota in Juvenile Sika Deer During Early Growth
Authors: Li Songze , Mu Ruina , Zhang Yunxi , Wang Shaoying , Wright André-Denis G. , Si Huazhe , Li Zhipeng
Published: January 2025

The establishment of gut microbiota in young ruminants has a profound impact on their productive performance in adulthood. The microbial communities of ruminants differ significantly across the different regions of the digestive tract, as well as between the mucosa and lumen. In this study, we analyzed the characteristics of the microbiota of the small intestine (jejunum and ileum) and large intestine (cecum and colon) of sika deer on day 1 (birth), day 42 (transition period) and day 70 (rumination period) using 16S rRNA gene sequencing. The results showed that the microbial diversity of the mucosa in the jejunum, ileum, cecum and colon of sika deer was higher on day 70 than on day 1, and the diversity of the cecal mucosa was significantly higher than that in the small intestine. Principal coordinates analysis (PCoA) showed that the microbial community structures of the small and large intestinal mucosa were significantly different, and the microbial community structure of sika deer on day 1 was significantly different from that on days 42 and 70. The relative abundances of Methylobacterium–Methylorubrum, Pelagibacterium, Acinetobacter and Staphylococcus were higher in the small intestinal mucosa, while Alistipes, Prevotellaceae UCG-004, Eubacterium coprostanoligenes group and Lachnospiraceae unclassified were higher in the large intestinal mucosa. We also observed increased levels of specific microbiota in the small intestinal (Turicibacter and Cellulosilyticum) and large intestinal mucosa (Treponema, Romboutsia, Oscillospirales UCG-005 and Peptostreptococcaceae unclassified) with animal growth. A comparison of the predicted function showed that the microbiota of the small intestinal mucosa was enriched for replication and repair, while carbohydrate metabolism was enriched in the microbiota of the large intestinal mucosa. In addition, the relative abundances of amino acid and energy metabolism were significantly higher on days 42 and 70 than on day 1. Our results revealed that the microbial community composition and the dynamics of the intestinal mucosa from birth to rumination in juvenile sika deer, which may provide insights into similar processes in other juvenile ruminants.
Genomic Tools for Medicinal Properties of Goat Milk for Cosmetic and Health Benefits: A Narrative Review
Authors: Ncube Keabetswe T. , Modiba Mamokoma C. , Mpofu Takalani J. , Nephawe Khathutshelo A. , Mtileni Bohani
Published: January 2025

Goat milk has gained recognition for its medicinal, cosmetic, and health benefits, particularly its potential to improve human skin conditions. Its therapeutic properties are attributed to bioactive compounds influenced by genes such as lactoferrin (LTF), lysozyme (LYZ), and β-casein (CSN2), known for their antimicrobial, immunomodulatory, and anti-inflammatory effects. Genetic factors are hypothesized to shape goat milk’s composition and its effectiveness in managing dermatological conditions like eczema and psoriasis. Understanding these genetic determinants is critical to optimizing the use of goat milk in skin health applications. This review aims to explore the application of genomic tools to elucidate the medicinal properties of goat milk and its implications for skin care. By identifying the specific genes and molecular mechanisms underpinning its therapeutic effects, genomic studies have provided insights into the bioactive constituents of goat milk, such as peptides, proteins, and lipids, which contribute to its dermatological efficacy. Candidate genes, including growth hormone receptor (GHR), butyrophilin (BTN1A1), and lactoglobulin (LGB), have been identified as critical for enhancing milk quality and functionality. Future research should integrate genomic data with functional studies to further investigate goat milk’s immunomodulatory, antimicrobial, and antioxidant activities. Such insights could advance targeted breeding strategies and innovative formulations for managing inflammatory skin conditions and promoting skin health.
Rice Responses to Abiotic Stress: Key Proteins and Molecular Mechanisms
Authors: Wang Xiaohui , Liu Xuelei , Su Yonglin , Shen Huaizong
Published: January 2025

The intensification of global climate change and industrialization has exacerbated abiotic stresses on crops, particularly rice, posing significant threats to food security and human health. The mechanisms by which rice responds to these stresses are complex and interrelated. This review aims to provide a comprehensive understanding of the molecular mechanisms underlying rice’s response to various abiotic stresses, including drought, salinity, extreme temperatures, and heavy metal pollution. We emphasize the molecular mechanisms and structural roles of key proteins involved in these stress responses, such as the roles of SLAC1 and QUAC1 in stomatal regulation, HKT and SOS proteins in salinity stress, heat shock proteins (HSPs) and heat stress transcription factors (HSFs) in temperature stress, and Nramp and ZIP transport proteins in response to heavy metal stress. This review elucidates the complex response networks of rice to various abiotic stresses, highlighting the key proteins and their related molecular mechanisms, which may further help to improve the strategies of molecular breeding.
Non-Animal Hyaluronic Acid and Probiotics Enhance Skin Health via the Gut–Skin Axis: An In Vitro Study on Bioavailability and Cellular Impact
Authors: Galla Rebecca , Mulè Simone , Ferrari Sara , Molinari Claudio , Uberti Francesca
Published: January 2025

Hyaluronic acid (HA) represents a pivotal component of the extracellular matrix, particularly within the context of the skin. The absorption and metabolism of orally ingested HA have been extensively investigated due to the prevalence of HA-based supplements. The objective of this study was to evaluate the impact of a combination of non-animal HA and Bifidobacterium longum novaBLG1 on dermal health following intestinal transit. The bioavailability of the compound was evaluated using a model that reproduced the human intestinal barrier in vitro, and its biological effects were investigated on skin cells via the gut–skin axis. The results demonstrated that probiotics augmented the absorption of non-animal HA by approximately 30% in comparison to non-animal HA alone and by 82% in comparison to sodium hyaluronate. Furthermore, the combination demonstrated a notable enhancement in skin cell proliferation, with increases of 16%, 8%, and 29.7% over 144 h in comparison to non-animal hyaluronan, Bifidobacterium longum novaBLG1, and sodium hyaluronate, respectively. The combination was observed to positively affect all markers of skin health and well-being, achieving its goals without any adverse effects on the gut. This approach offers a novel method for enhancing skin health.
Study of the Wound-Healing Activity of a New Drug Derived from Cobalt Polyacrylate
Authors: Vasilyeva Anna P. , Svinarev Andrey V. , Ogurtsov Vladimir A. , Khodot Evgeny N. , Rakitin Oleg A. , Trubnikova Elena V. , Shcherbakova Elena S. , Smirnova Maria S. , Shishkina Victoria V. , Samoylenko Tatyana V. , Shevelev Alexei B.
Published: January 2025

Previously we suggested a new pharmaceutical derived from coordination complex of Co3+ with polyacrylic acid (PAA) exhibiting hemostatic and microbicidal activity, namely Hestatin. Differences in the physiological activity of Hestatin synthesized from PAA 10 kDa (Hestatin 10) and 200 kDa (Hestatin 200) were shown. We tested the acute toxicity of Hestatin and its effect on the healing rate of sterile wounds in rats. Free 10 kDa PAA, emulsion wax, emulsion wax carrying resveratrol, and dexpanthenol were tested for comparison. Hestatin 10 exhibited no acute toxicity when administered intragastrically at dosages of 5 g per kg. Hestatin 10 surpassed all tested drugs in its wound healing ability. Histological analysis of skin sections of rats in the area of healing defects showed an increased rate of synthesis of reticular fibers compared to the placebo. In the early stages of wound healing (inflammatory phase), Hestatin 10 stimulated taxis of mast cells (MCs) to the wound bottom but not to the wound perimeter. At the final stage of wound healing (remodeling phase), Hestatin 10 promoted MC evacuation from the skin defect area. This effect is the opposite of the well-known wound-healing agents (dexpanthenol and resveratrol), which enhance MC infiltration into the defect area in the remodeling phase.
Multicore, SDS-Based Polyelectrolyte Nanocapsules as Novel Nanocarriers for Paclitaxel to Reduce Cardiotoxicity by Protecting the Mitochondria
Authors: Szwed Marzena , Poczta-Krawczyk Anastazja , Kania Katarzyna D. , Wiktorowski Kacper , Podsiadło Kamila , Marczak Agnieszka , Szczepanowicz Krzysztof
Published: January 2025

The clinical application of paclitaxel (PTX), a widely used anticancer drug, is constrained by cardiac arrhythmias and disruptions in vascular homeostasis. To mitigate the non-specific, high toxicity of PTX towards cardiomyocytes, we propose the application of newly synthesized SDS-based polyelectrolyte multicore nanocapsules. This study aims to verify the hypothesis that SDS-based NCs can mitigate the cytotoxic effects of PTX on cardiac cells and serve as effective nanocarriers for this drug. We investigated two types of multicore NCs with differing polyelectrolyte coatings: poly-L-lysine (PLL) and a combination of PLL with poly-L-glutamic acid (PGA). The cytotoxicity of the formulated nanosystems was evaluated using HL-1 cardiomyocytes. Oxygraphy, flow cytometry, spectrophotometry, spectrofluorimetry, fluorescence microscopy, and RT-PCR were employed to assess disruptions in cardiac cellular homeostasis. Our data revealed that, among the tested NCs, SDS/PLL/PGA/PTX exhibited reduced cardiotoxicity and were better tolerated by HL−1 cardiomyocytes compared to SDS/PLL/PTX or PTX alone. In addition, SDS/PLL/PGA/PTX showed a marginal disruption of mitochondria’s homeostasis, and no changes in APT level and intracellular calcium concentrations were observed. These findings underscore the potential of SDS-based multicore nanocarriers in anticancer therapy, particularly due to diminished cardiotoxicity and long-term stability in the biological fluids.
Heterostructure Based of Ti-TiO2(NW)/rGO Hybrid Materials for Electrochemical Applications
Authors: Morariu (Popescu) Mina-Ionela , Nicolaescu Mircea , Orha Corina , Lăzău Carmen , Duteanu Narcis , Bandas Cornelia
Published: January 2025

This study investigated a hybrid electrode based on titanium/titanium dioxide nanowires/reduced graphene oxide (Ti-TiO2(NW)/rGO) that was developed in two stages. The Ti-TiO2(NW)/rGO was obtained by hydrothermal treatment in a mixed solution of H2O2 and melamine for Ti-TiO2 support, followed by a simple spin-coating deposition method and thermal oxidation in a controlled atmosphere of nitrogen gas (99%). The as-prepared structures of electrodes were characterized using ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Raman spectroscopy, and scanning electron microscopy (SEM). In addition, the electrochemical behavior was assessed by cyclic voltammetry (CV) in a 1M HNO3-supporting electrolyte and in the presence of 4 mM K4Fe(CN)6 3H2O to determine the electroactive surface area and apparent diffusion coefficient of the hybrid electrode. The development of the Ti-TiO2(NW)/rGO hybrid electrode provides a sensitive method for photo-electrooxidation of doxorubicin due to exploiting the synergistic and remarkable properties of the nanowires of TiO2 and of reduced graphene oxide (rGO) layer on the electrode surface.
Characteristics and Outcomes of Pulmonary Embolism Patients Transferred After Activation of Pulmonary Embolism Response Team and Admitted from Local Emergency Department
Authors: Jermakow Mateusz , Machowski Michał , Gałecka-Nowak Magdalena , Deutsch Karol , Il Adam , Imiela Anna , Karolak Bartosz , Perzanowska-Brzeszkiewicz Katarzyna , Pacho Szymon , Wójcik Agnieszka , Roik Marek , Krakowian Marcin , Łabyk Andrzej , Gołębiowski Marek , Pruszczyk Piotr
Published: January 2025

Background: The primary role of a pulmonary embolism response team (PERT) is to support decision-making processes regarding acute pulmonary embolism (PE) patients and provide advanced rescue therapies when needed. Despite a great need for its availability among physicians, PERT’s usefulness is yet to be proven. Objectives: Our goal was to establish whether patients benefit from qualification by PERT for admission to a tertiary cardiology ward. Methods: Data of all patients hospitalized due to PE for 12 months (July 2023–June 2024) were retrospectively analyzed. We aimed to compare patients admitted primarily via the emergency department with those consulted by PERT and eventually transferred from other hospitals. The primary outcome was the use of advanced therapies. Results: We identified 167 patients (50.3% women) hospitalized with PE. Out of them, 102 (61.1%) came from the emergency department, while 65 (38.9%) patients were transferred after PERT consultation. The transferred patients generally had more severe conditions, as indicated by the ESC death risk group classification (intermediate-high and high risk, OR 19.2, 95% CI 8.3–44.2). They were more often qualified for at least one of the advanced therapies than the emergency department patients (OR 23.2, 95% CI 9.3–58.1). We found no significant differences in in-hospital mortality (6.9% versus 1.5%, OR 4.7, 95% CI 0.6–39.3). Conclusions: Establishing PERT as a reference unit providing advanced treatment resulted in successfully delivering more complex treatment to severely ill PE patients. Despite their unfavorable basic characteristics, neither length of hospitalization nor in-hospital mortality seem to differ when compared to unselected, less compromised cases.
Validation of the NICHD Bronchopulmonary Dysplasia Outcome Estimator 2022 in a Quaternary Canadian NICU—A Single-Center Observational Study
Authors: Kanagaraj Uthaya Kumaran , Kulkarni Tapas , Kwan Eddie , Zhang Qian , Bone Jeffery , Shivananda Sandesh
Published: January 2025

Background/Objectives: The numerical risk of bronchopulmonary dysplasia (BPD) and/or death could be estimated using the National Institute of Child Health and Human Development (NICHD) BPD outcome estimator 2022 in extremely low gestational age (ELGA) infants during the first 4 weeks of life to facilitate prognostication, and center-specific targeted improvement interventions. However, the 2022 NICHD BPD outcome estimator’s performance in the Canadian setting has not been validated. Our objective is to validate the NICHD BPD outcome estimator 2022 in predicting death and or moderate to severe BPD at 36 weeks in infants less than 29 weeks admitted to NICU. Methods: A retrospective observational study (March 2022–August 2023) was conducted on both inborn and outborn preterm infants excluding neonates with major congenital anomalies. Infants were classified into six groups based on the predicted risk of death or Grade 2 or 3 BPD (<10%, 10–20%, 20–30%, 30–40%, 50–59%, ≥60%) followed by noting observed outcomes from the unit’s database. A receiver operating characteristics (ROC) curve was used to assess the accuracy of the NICHD BPD outcome estimator 2022, with an area under curve (AUC) > 0.7 defined a priori as an acceptable predictive accuracy for local use. Results: Among 99 infants included, 13 (13.1%) died, and 40 (40.4%) developed BPD. Median gestational age was 26 weeks, and median birth weight was 914 g. Twenty-three infants (23.2%) received postnatal steroids. The AUC values for death or moderate to severe BPD on days 1, 3, 7, 14, and 28 were 0.803, 0.806, 0.837, 0.832, and 0.843, respectively. The AUC values for moderate to severe BPD alone on those days were 0.766, 0.746, 0.785, 0.807, and 0.818 respectively. Conclusions: The 2022 BPD estimator adequately predicted the death and/or moderate to severe BPD on days 1, 3, 7, 14, and 28 of life. This tool could serve as a valid adjunct to facilitate discussion between clinicians and families on initiating time-sensitive targeted interventions to prevent or alter the course of BPD.
Myopia Management in Hong Kong
Authors: Zhang Han-Yu , Xu Fang-Yu , Liu Kenneth Ka King , Chan Yan-Pui , Chow Amy , Jones Deborah , Lam Carly Siu Yin
Published: January 2025

Objectives: We aimed to investigate how optometrists in Hong Kong are managing myopic and “pre-myopic” children. Methods: Clinical files for children aged 6 to 10 years old who had eye examinations from 2017 to 2021 were retrospectively reviewed. Children were grouped by the initial spherical equivalent refractive error (SER) as myopes or pre-myopes. The demographic data, refractive error, and myopia management recommended by the optometrists were analyzed. Results: A total of 1,318 children (859 myopes and 459 pre-myopes) from ten clinics in Hong Kong were included. Over 5 years, myopia management recommendations shifted significantly (p < 0.001). In 2017, only 18.4% of children were recommended to pursue myopia control (MC), increasing to 42.8% by 2021. The use of MC spectacle lenses increased from 7.3% in 2017 to 36.8% in 2021, becoming the most recommended option. Orthokeratology, MC contact lenses, and atropine remained stable at less than 5% over this period. Children recommended for MC approaches had significantly more myopia than those recommended single-vision lenses or monitoring (p < 0.05). Age of the first visit significantly correlated with SER change from the first visit to the next recommendation update for pre-myopes (r = 0.27, p = 0.013) but not for myopes. Conclusions: From 2017 to 2021, myopia management patterns in Hong Kong shifted significantly, with more children being recommended for myopia control. MC spectacle lenses emerged as the most commonly recommended method. Younger pre-myopes at their first visit were more likely to have earlier management updates.
Revolutionizing Restorative Dentistry: The Role of Polyethylene Fiber in Biomimetic Dentin Reinforcement—Insights from In Vitro Research
Authors: Ferrando Cascales Álvaro , Andreu Murillo Andrea , Ferrando Cascales Raúl , Agustín-Panadero Rubén , Sauro Salvatore , Carreras-Presas Carmen Martín , Hirata Ronaldo , Lijnev Artiom
Published: January 2025

Recent advancements in biomimetic dentistry have introduced innovative materials designed to better simulate natural dentin. One such material is Ribbond®, long polyethylene fiber. It is particularly effective in absorbing and redistributing masticatory forces in teeth with substantial dentin loss. This review aims to analyze the literature on the biomimetic restorative technique using long polyethylene fiber and assess its benefits and indications relative to traditional cusp coverage restorations. Methods: A search was conducted in the PubMed database until March 2024. The authors selected in vitro studies that studied long polyethylene fiber as a dentin reinforcement. Results: From 247 potentially relevant articles, eighteen studies were included in the review. A detailed analysis of the reviewed literature was summarized into three principal sections involving the use of long polyethylene fiber in restorative dentistry. Conclusions: Long polyethylene fibers improve fracture resistance and promote favorable fracture modes, helping to mitigate the shrinkage forces in composite restorations. However, their clinical significance over traditional cusp coverage is unclear.
Fusion of In-Situ and Modelled Marine Data for Enhanced Coastal Dynamics Prediction Along the Western Black Sea Coast
Authors: Mihailov Maria Emanuela , Chirosca Alecsandru Vladimir , Chirosca Gianina
Published: January 2025

This study explores the use of Temporal Fusion Transformers (TFTs), an AI/ML technique, to enhance the prediction of coastal dynamics along the Western Black Sea coast. We integrate in-situ observations from five meteo-oceanographic stations with modelled geospatial marine data from the Copernicus Marine Service. TFTs are employed to refine predictions of shallow water dynamics by considering atmospheric influences, with a particular focus on wave-wind correlations in coastal regions. Atmospheric pressure and temperature are treated as latitude-dependent constants, with specific investigations into extreme events like freezing and solar radiation-induced turbulence. Explainable AI (XAI) is exploited to ensure transparent model interpretations and identify key influential input variables. Data attribution strategies address missing data concerns, while ensemble modelling enhances overall prediction robustness. The models demonstrate a significant improvement in prediction accuracy compared to traditional methods. This research provides a deeper understanding of atmosphere-marine interactions and demonstrates the efficacy of Artificial intelligence (AI)/Machine Learning (ML) in bridging observational and modelled data gaps for informed coastal zone management decisions, essential for maritime safety and coastal management along the Western Black Sea coast.
Finite-Time Fault-Tolerant Tracking Control for an Air Cushion Vehicle Subject to Actuator Faults
Authors: Yu Renhai , Zhou Qizheng , Li Tieshan
Published: January 2025

This paper proposes a finite-time fault-tolerant tracking controller for an air cushion vehicle (ACV) based on the backstepping method. A four-degree-of-freedom ACV with model uncertainties is considered, where the unknown nonlinearities can be approximated by radial basis function neural networks. By combining the command filter with the backstepping method, the calculation of virtual control derivatives is avoided. The proposed adaptive finite-time fault-tolerant controller can estimate the unknown boundaries of actuator fault parameters so that an unbounded number of actuator faults can be processed. The proposed theory ensures that the stability of the system and its tracking performance can be guaranteed in a finite time. This paper focuses on simulation-based work. Simulation results confirm the capability of the proposed trajectory tracking control scheme.
Assessing Threats to Fazao-Malfakassa National Park, Togo, Using Birds as Indicators of Biodiversity Conservation
Authors: Kaboumba Lin-Ernni Mikégraba , Di Lecce Irene , Afiademanyo Komlan M. , Kourdjouak Yendoubouam , Arcilla Nico
Published: January 2025

Protected areas are crucial for the conservation of West Africa’s increasingly imperiled wildlife, but are under unprecedented pressure associated with exponential human population growth in the region. Using birds as biodiversity indicators, we investigated the conservation status of Togo’s Fazao-Malfakassa National Park, which was managed by a private foundation from 1990 to 2015, and since 2015 has been managed by the state. Between 2022 and 2024, we conducted 90 days of bird surveys in the park and documented a total of 240 bird species. Our findings include 34 species new to the park, including the first record of Emin’s Shrike (Lanius gubernator) in Togo, the first sightings of the Great Blue Turaco (Corythaeola cristata) since 1990, and first observations of the Abyssinian Ground-Hornbill (Bucorvus abyssinicus) since 2019. Many such species survive in Togo only in Fazao-Malfakassa National Park, but its exceptional biodiversity has come under increasing assault from illegal activities, including poaching, logging, road construction, charcoal production, cattle grazing, and land clearance to establish agricultural plantations. We were unable to document 91 bird species previously reported for the park during our surveys, suggesting a possible ~31% decline in avian species richness in the park compared to historical records. Apparent extirpations of globally-threatened raptors such as the Critically Endangered White-backed Vulture (Gyps africanus) and Hooded Vulture (Necrosyrtes monachus), and declines of the Endangered Bateleur (Terathopius ecaudatus) and Martial Eagle (Polemaetus bellicosus) further indicate that current conservation strategies are failing to adequately protect wildlife in the park. Togo’s two other historical national parks have already been almost entirely destroyed by human activities, and unless urgent conservation action is taken, there is a high risk that Fazao-Malfakassa National Park will share the same fate. We urgently recommend improving support for law enforcement capacity and park staff, conducting community conservation outreach, and ongoing monitoring of wildlife in the park to assess its conservation success.
Synergistic Enhancement Effect of Polytetrafluoroethylene and WSe2 on the Tribological Performance of Polyetherimide Composites
Authors: Tu Fulin , Wang Bin , Zhao Simo , Liu Mingrui , Zheng Jiangye , Li Zewen , Hu Chengyang , Jiang Tao , Zhang Qunchao
Published: January 2025

To address the issue of high wear of polymer composites during friction, WSe2 nanofillers were incorporated into the polymer matrix as a reinforcing phase to enhance heat transfer and improve the composites’ wear resistance. Tannic acid (TA) was grafted onto the surface of WSe2 through high-energy ball milling, which facilitated the exfoliation of the nanofillers and improved their interfacial compatibility with the matrix material. Tribological experiments revealed that adding 5 wt% TA-WSe2 reduced the friction coefficient and volumetric wear rate to 0.0065 and 8.7 × 10−4 μm3/N·m, respectively, representing reductions of 98% and 94% compared to pure PEI. The TA-WSe2 not only served as a reinforcing phase to enhance heat transfer but also facilitated the timely dissipation of heat generated during friction. Additionally, it formed strong interfacial bonds with both PEI and PTFE, allowing the applied load to be efficiently distributed throughout the composite material. This study offers a practical approach for the functionalization of WSe2 and the development of ternary composite materials for tribological applications.
Effect of Purge on Secondary Flows in Turbine Due to Interaction Between Cavity Flow and Main Channel
Authors: Biassoni Daniele , Barsi Dario , Lengani Davide
Published: January 2025

Nowadays, a lot of efforts are being made to increase turbine inlet temperatures (TIT), with the aim of increasing efficiency in aircraft and power generation turbines. Due to the higher temperature level, advanced cooling solutions to preserve material durability are necessary. It is essential to avoid contact between hot gases and the temperature-sensitive components, such as the stator and rotor cavity disks. Modern gas turbine performance optimization centers on reducing leakage and refining sealing systems. The interaction between the main flow and cavity flow in stator/rotor systems has a significant role in loss generation. This study employs Unsteady Reynolds-Averaged Navier–Stokes (URANS) simulations to investigate the unsteady interactions within the stator/rotor cavity of a low-pressure turbine. Numerical results are compared and validated against experimental data obtained in the cavity rig of the University of Genova. The research focuses on the effects of stator/rotor interactions, including wake ingestion from upstream rotor bars and the blocking influence of downstream potential effects on cavity sealing effectiveness. In this paper, a comparison between the zero cooling air flow rate and cavity sealing condition is shown. Special attention is given to unsteady loss mechanisms occurring downstream of the vane row and in areas where the cavity flow re-enters the main channel, showing how cooling flow rates affect these losses. From this study, it can be seen that by increasing the cooling flow rate injected into the cavity, there is an increase in the hub’s passage vortex effect and there is a more intense interaction between the main flow and the cavity flow. These results offer valuable insights into the mechanisms of interaction between the main flow and cavity flow.
Directional Handover Analysis with Stochastic Petri Net and Poisson Point Process in Heterogeneous Networks
Authors: Zhu Zhiyi , Zheng Junjun , Takimoto Eiji , Finnerty Patrick , Ohta Chikara
Published: January 2025

Handover is crucial for ensuring seamless connectivity in heterogeneous networks (HetNet) by enabling user equipment (UE) to switch its connection link between cells based on signal conditions. However, conventional analytical approaches ignored the distinctions between macro-cell to small-cell (M2S) and small-cell to macro-cell (S2M) scenarios during a handover decision-making process, which resulted in handover failures (HoF) or ping-pong handovers. Therefore, this paper proposes a novel framework, Do-SPN-PPP, that combines stochastic Petri net (SPN) and the Poisson point process (PPP) to quantitatively analyze M2S and S2M handover performance differences. The proposed framework also reveals and predicts how handover parameters affect UE residence time in a cell within the HetNet, and it exhibits a higher predictive accuracy compared with the traditional conventional analytical approach. In addition, the Monte Carlo simulation verified the Do-SPN-PPP framework, and the proposed framework exhibits a 96% reduction in computation time while maintaining a 95% confidence interval and 0.5% error tolerance compared with the simulation.
Microbiome Engineering for Sustainable Rice Production: Strategies for Biofertilization, Stress Tolerance, and Climate Resilience
Authors: Misu Israt Jahan , Kayess Md. Omar , Siddiqui Md. Nurealam , Gupta Dipali Rani , Islam M. Nazrul , Islam Tofazzal
Published: January 2025

The plant microbiome, found in the rhizosphere, phyllosphere, and endosphere, is essential for nutrient acquisition, stress tolerance, and the overall health of plants. This review aims to update our knowledge of and critically discuss the diversity and functional roles of the rice microbiome, as well as microbiome engineering strategies to enhance biofertilization and stress resilience. Rice hosts various microorganisms that affect nutrient cycling, growth promotion, and resistance to stresses. Microorganisms carry out these functions through nitrogen fixation, phytohormone and metabolite production, enhanced nutrient solubilization and uptake, and regulation of host gene expression. Recent research on molecular biology has elucidated the complex interactions within rice microbiomes and the signalling mechanisms that establish beneficial microbial communities, which are crucial for sustainable rice production and environmental health. Crucial factors for the successful commercialization of microbial agents in rice production include soil properties, practical environmental field conditions, and plant genotype. Advances in microbiome engineering, from traditional inoculants to synthetic biology, optimize nutrient availability and enhance resilience to abiotic stresses like drought. Climate change intensifies these challenges, but microbiome innovations and microbiome-shaping genes (M genes) offer promising solutions for crop resilience. This review also discusses the environmental and agronomic implications of microbiome engineering, emphasizing the need for further exploration of M genes for breeding disease resistance traits. Ultimately, we provide an update to the current findings on microbiome engineering in rice, highlighting pathways to enhance crop productivity sustainably while minimizing environmental impacts.
The Influence of pH on Long-Range Electron Transfer and Proton-Coupled Electron Transfer in Ruthenium-Modified Azurin
Authors: Ghazi Nikta , Warren Jeffrey J.
Published: January 2025

Long-range electron transfer (ET) is an essential component of all biological systems. Reactions of metalloproteins are important in this context. Recent work on protein “charge ladders” has revealed how the redox state of embedded metal ions can influence the ionization of amino acid residues at protein surface sites. Inspired by these observations, we carried out a variable pH investigation of intramolecular ET reactions in a ruthenium-modified protein system built on azurin from Pseudomonas aeruginosa. We also generate a Pourbaix diagram that describes the variable pH redox behavior of a Ru model complex, Ru(2,2′-bipyridyl)2(imidazole)2(PF6)2. The intramolecular ET rate constants for the oxidation of azurin-Cu+ by flash-quench-generated Ru3+ oxidants do not follow the predictions of the semi-classical ET rate expression with fixed values of reorganization energy (λ) and electronic coupling (HDA). Based on the pH dependence of the Ru3+/2+ redox couple, we propose a model where pure ET is operative at acidic pH values (≤ 7) and the mechanism changes to proton-coupled electron transfer at pH ≥ 7.5. The implications of this mechanistic proposal are discussed in the context of biological redox reactions and with respect to other examples of intramolecular ET reactions in the literature.
Engineering Nonvolatile Polarization in 2D α-In2Se3/α-Ga2Se3 Ferroelectric Junctions
Authors: Li Peipei , Kong Delin , Yang Jin , Cui Shuyu , Chen Qi , Liu Yue , He Ziheng , Liu Feng , Xu Yingying , Wei Huiyun , Zheng Xinhe , Peng Mingzeng
Published: January 2025

The advent of two-dimensional (2D) ferroelectrics offers a new paradigm for device miniaturization and multifunctionality. Recently, 2D α-In2Se3 and related III–VI compound ferroelectrics manifest room-temperature ferroelectricity and exhibit reversible spontaneous polarization even at the monolayer limit. Here, we employ first-principles calculations to investigate group-III selenide van der Waals (vdW) heterojunctions built up by 2D α-In2Se3 and α-Ga2Se3 ferroelectric (FE) semiconductors, including structural stability, electrostatic potential, interfacial charge transfer, and electronic band structures. When the FE polarization directions of α-In2Se3 and α-Ga2Se3 are parallel, both the α-In2Se3/α-Ga2Se3 P↑↑ (UU) and α-In2Se3/α-Ga2Se3 P↓↓ (NN) configurations possess strong built-in electric fields and hence induce electron–hole separation, resulting in carrier depletion at the α-In2Se3/α-Ga2Se3 heterointerfaces. Conversely, when they are antiparallel, the α-In2Se3/α-Ga2Se3 P↓↑ (NU) and α-In2Se3/α-Ga2Se3 P↑↓ (UN) configurations demonstrate the switchable electron and hole accumulation at the 2D ferroelectric interfaces, respectively. The nonvolatile characteristic of ferroelectric polarization presents an innovative approach to achieving tunable n-type and p-type conductive channels for ferroelectric field-effect transistors (FeFETs). In addition, in-plane biaxial strain modulation has successfully modulated the band alignments of the α-In2Se3/α-Ga2Se3 ferroelectric heterostructures, inducing a type III–II–III transition in UU and NN, and a type I–II–I transition in UN and NU, respectively. Our findings highlight the great potential of 2D group-III selenides and ferroelectric vdW heterostructures to harness nonvolatile spontaneous polarization for next-generation electronics, nonvolatile optoelectronic memories, sensors, and neuromorphic computing.
Investigating Benzoic Acid Derivatives as Potential Atomic Layer Deposition Inhibitors Using Nanoscale Infrared Spectroscopy
Authors: Satyarthy Saumya , Cheng Mark , Ghosh Ayanjeet
Published: January 2025

Area-selective atomic layer deposition (AS-ALD) is a technique utilized for the fabrication of patterned thin films in the semiconductor industry due to its capability to produce uniform and conformal structures with control over thickness at the atomic scale level. In AS-ALD, surfaces are functionalized such that only specific locations exhibit ALD growth, thus leading to spatial selectivity. Self-assembled monolayers (SAMs) are commonly used as ALD inhibiting agents for AS-ALD. However, the choice of organic molecules as viable options for AS-ALD remains limited and the precise effects of ALD nucleation and exposure to ALD conditions on the structure of SAMs is yet to be fully understood. In this work, we investigate the potential of small molecule carboxylates as ALD inhibitors, namely benzoic acid and two of its derivatives, 4-trifluoromethyl benzoic acid (TBA), and 3,5-Bis (trifluoromethyl)benzoic acid (BTBA) and demonstrate that monolayers of all three molecules are viable options for applications in ALD blocking. We find that the fluorinated SAMs are better ALD inhibitors; however, this property arises not from the hydrophobicity but the coordination chemistry of the SAM. Using nanoscale infrared spectroscopy, we probe the buried monolayer interface to demonstrate that the distribution of carboxylate coordination states and their evolution is correlated with ALD growth, highlighting the importance of the interfacial chemistry in optimizing and assessing ALD inhibitors.