bluuebunny/crossref_metadata_2025 huggingface dataset:
A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS
Authors: Tan Haowen , Yan Xida , Chen Ying , Huang Guili , Luo Luping , Li Wenjun , Lan Weiwei , Chen Cheng , Xi Xin
Published: May 2024

Purpose

To identify the most commonly reported drugs associated with QT interval prolongation in the FDA Adverse Event Reporting System (FAERS) and evaluate their risk for QT interval prolongation.

Methods

We employed the preferred term (PT) “electrocardiogram QT prolonged” from the Medical Dictionary for Regulatory Activities (MedDRA) 26.0 to identify adverse drug events (ADEs) of QT interval prolongation in the FAERS database from the period 2004–2022. Reporting odds ratio (ROR) was performed to quantify the signals of ADEs.

Results

We listed the top 40 drugs that caused QT interval prolongation. Among them, the 3 drugs with the highest number of cases were quetiapine (1,151 cases, ROR = 7.62), olanzapine (754 cases, ROR = 7.92), and citalopram (720 cases, ROR = 13.63). The two most frequently reported first-level Anatomical Therapeutic Chemical (ATC) groups were the drugs for the nervous system (n = 19, 47.50%) and antiinfectives for systemic use (n = 7, 17.50%). Patients with missing gender (n = 3,482, 23.68%) aside, there were more females (7,536, 51.24%) than males (5,158, 35.07%) were involved. 3,720 patients (25.29%) suffered serious clinical outcomes resulting in deaths or life-threatening conditions. Overall, most drugs that caused QT interval prolongation had early failure types according to the assessment of the Weibull's shape parameter (WSP) analysis.

Conclusions

Our study offered a list of drugs that frequently caused QT interval prolongation based on the FAERS system, along with a description of some risk profiles for QT interval prolongation brought on by these drugs. When prescribing these drugs in clinical practice, we should closely monitor the occurrence of ADE for QT interval prolongation.
Causal role of immune cells in Hashimoto’s thyroiditis: Mendelian randomization study
Authors: Zhao Zhendan , Gao Yuehua , Pei Xiaoqing , Wang Wenhao , Zhang Huawei
Published: May 2024

Objectives

Hashimoto’s thyroiditis (HT) is a common autoimmune disease whose etiology involves a complex interplay between genetics and environment. Previous studies have demonstrated an association between immune cells and HT. However, the casual relationship was not clear. We aimed to explore the causal associations between signatures of immune cells and HT.

Methods

In this study, bidirectional two-sample Mendelian randomization (MR) analysis was conducted to investigate the potential causal relationship between 731 immune cell signatures and HT by using genome-wide association study (GWAS) data. Heterogeneity and horizontal pleiotropy were detected through extensive sensitivity analyses.

Results

The increased levels of six immune phenotypes were observed to be causally associated with increased risk of HT P < 0.01, which were CD3 on CM CD8br, CD3 on CD39+ secreting Treg, HLA DR on CD33dim HLA DR+ CD11b−, CD3 on CD4 Treg, CD62L− plasmacytoid DC %DC, and CD3 on CD45RA+ CD4+. In addition, the levels of FSC-A on HLA DR+ T cell and CD62L on monocyte were associated with disease risk of HT P < 0.01. In addition, HT also had causal effects on CD3 on CM CD8br, CCR2 on monocyte, CD25 on CD39+ resting Treg, and CCR2 on CD62L+ myeloid DC P < 0.05.

Conclusions

In this study, we demonstrated the genetic connection between immune cell traits and HT, thereby providing guidance and direction for future treatment and clinical research.
Case report: Secondary failure to tolvaptan in a patient with SCLC and paraneoplastic SIADH
Authors: Menzi Sheryl , Jaramillo Silvia Daniela , Pfister Stephan , Schefer Hubert , Jehle Andreas Werner
Published: May 2024

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is frequent in lung cancer patients. Here, we report a case with persistent hyponatremia, which suggested malignant SIADH and facilitated an early diagnosis of small cell lung cancer (SCLC). A combined radio-chemotherapy led to a partial remission and resolution of SIADH. An early relapse was indicated by reoccurring severe hyponatremia and increased copeptin levels, which were used as surrogate markers for the antidiuretic hormone (ADH). As palliative immunochemotherapy, together with fluid restriction and solute substitution, were unable to control hyponatremia, treatment with the ADH V2-receptor antagonist tolvaptan was initiated. Over time, the dose of tolvaptan needed to be increased, paralleled by a well-documented exponential increase of copeptin levels. In summary and conclusion, this is a rare case of a secondary failure to tolvaptan with unique documentary evidence of increasing copeptin levels. This observation supports the hypothesis that exceedingly high ADH levels may lead to competitive displacement of tolvaptan from the V2 receptor.
CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization
Authors: Singh Anjana , Kraaijeveld Adriaan O. , Curaj Adelina , Wichapong Kanin , Hammerich Linda , de Jager Saskia C. A. , Bot Ilze , Atamas Sergei P. , van Berkel Theo J. C. , Jukema J. Wouter , Comerford Iain , McColl Shaun R. , Mees Barend , Heemskerk Johan W. M. , Nicolaes Gerry A. F. , Hackeng Tilman , Liehn Elisa Anamaria , Tacke Frank , Biessen Erik A. L.
Published: May 2024

Introduction

The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the role of CCL18 in the pathogenesis of human and mouse atherosclerosis.

Methods and results

CCL18 was profoundly upregulated in ruptured human atherosclerotic plaque, particularly within macrophages. Repeated administration of CCL18 in Western-type diet–fed ApoE−/− mice or PCSK9mut-overexpressing wild type (WT) mice led to increased plaque burden, enriched in CD3+ T cells. In subsequent experimental and molecular modeling studies, we identified CCR6 as a functional receptor mediating CCL18 chemotaxis, intracellular Ca2+ flux, and downstream signaling in human Jurkat and mouse T cells. CCL18 failed to induce these effects in vitro in murine spleen T cells with CCR6 deficiency. The ability of CCR6 to act as CCL18 receptor was confirmed in vivo in an inflammation model, where subcutaneous CCL18 injection induced profound focal skin inflammation in WT but not in CCR6−/− mice. This inflammation featured edema and marked infiltration of various leukocyte subsets, including T cells with a Th17 signature, supporting CCR6’s role as a Th17 chemotactic receptor. Notably, focal overexpression of CCL18 in plaques was associated with an increased presence of CCR6+ (T) cells.

Discussion

Our studies are the first to identify the CCL18/CCR6 axis as a regulator of immune responses in advanced murine and human atherosclerosis.
Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung
Authors: Bishop Cameron R. , Yan Kexin , Nguyen Wilson , Rawle Daniel J. , Tang Bing , Larcher Thibaut , Suhrbier Andreas
Published: May 2024

Introduction

Global microplastic (MP) pollution is now well recognized, with humans and animals consuming and inhaling MPs on a daily basis, with a growing body of concern surrounding the potential impacts on human health.

Methods

Using a mouse model of mild COVID-19, we describe herein the effects of azide-free 1 μm polystyrene MP beads, co-delivered into lungs with a SARS-CoV-2 omicron BA.5 inoculum. The effect of MPs on the host response to SARS-CoV-2 infection was analysed using histopathology and RNA-Seq at 2 and 6 days post-infection (dpi).

Results

Although infection reduced clearance of MPs from the lung, virus titres and viral RNA levels were not significantly affected by MPs, and overt MP-associated clinical or histopathological changes were not observed. However, RNA-Seq of infected lungs revealed that MP exposure suppressed innate immune responses at 2 dpi and increased pro-inflammatory signatures at 6 dpi. The cytokine profile at 6 dpi showed a significant correlation with the ‘cytokine release syndrome’ signature observed in some COVID-19 patients.

Discussion

The findings are consistent with the recent finding that MPs can inhibit phagocytosis of apoptotic cells via binding of Tim4. They also add to a growing body of literature suggesting that MPs can dysregulate inflammatory processes in specific disease settings.
Global research progress of gut microbiota and epigenetics: bibliometrics and visualized analysis
Authors: Tian Siyu , Chen Min
Published: May 2024

Background

Gut microbiota is an important factor affecting host health. With the further study of the mechanism of gut microbiota, significant progress has been made in the study of the link between gut microbiota and epigenetics. This study visualizes the body of knowledge and research priorities between the gut microbiota and epigenetics through bibliometrics.

Methods

Publications related to gut microbiota and epigenetics were searched in the Web of Science Core Collection (WoSCC) database. Vosviewer 1.6.17 and CiteSpace 6.1.R2 were used for bibliometric analysis.

Results

WoSCC includes 460 articles from 71 countries. The number of publications on gut microbiota and epigenetics has increased each year since 2011. The USA, PEOPLES R CHINA, and ITALY are at the center of this field of research. The University of California System, Harvard University, and the University of London are the main research institutions. Li, X, Yu, Q, Zhang, S X are the top authors in this research field. We found that current research hotspots and frontiers include short-chain fatty acids (SCFA) play an important role in gut microbiota and epigenetic mechanisms, gut microbiota and epigenetics play an important role in host obesity, diet, and metabolism. Gut microbiota and epigenetics are closely related to colorectal cancer, breast cancer, and inflammatory bowel disease. At the same time, we found that gut microbiota regulates epigenetics through the gut-brain axis and has an impact on psychiatric diseases. Therefore, probiotics can regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases.

Conclusion

This is the first comprehensive and in-depth bibliometric study of trends and developments in the field of gut microbiota and epigenetics research. This study helps to guide the direction of research scholars in their current field of study.
Case report: Endobronchial closure of postoperative bronchopleural fistula with embolization coil: a sandwich-like approach
Authors: Bai Yang , Chi Jing , Wang Hansheng , Li Yishi , Guo Shuliang
Published: May 2024

Background

Embolization Coil has been reported to effectively treat postoperative bronchopleural fistula (BPF). Little detailed information was available on computer tomography (CT) imaging features of postoperative BPF and treating procedures with pushable Embolization Coil.

Objective

We aimed to specify the imaging characteristics of postoperative BPFs and present our experience treating them with the pushable Embolization Coil.

Methods

Six consecutive patients (four males and two females aged 29–56 years) diagnosed with postoperative BPF receiving bronchoscopic treatment with the pushable Nester® Embolization Coil (Cook Medical, Bloomington, Indiana) were included in this single-center, retrospective study. Multiplanar reconstruction of multidetector CT scans was reviewed for the presence, location, size, and radiological complications of each BPF, including air collection, pneumothorax, bronchiectasis, and chest tube. Using standardized data abstraction forms, demographic traits and clinical outcomes were extracted from the medical files of these patients.

Results

The underlying diseases for lung resection surgery were pulmonary tuberculosis (n = 3), lung adenocarcinoma (n = 2), and pulmonary aspergillosis (n = 1). All patients had air or air-fluid collection with chest tubes on radiological findings. Multiplanar reconstruction identified the presence of postoperative BPF in all patients. Five fistulas were central, located proximal to the main or lobar bronchus, while one was peripheral, distant from the lobar bronchus. Fistula sizes ranged from 0.8 to 5.8 mm. Subsequent bronchoscopy and occlusion testing confirmed fistula openings in the bronchial stump: right main bronchus (n = 1), right upper lobe (n = 2), and left upper lobe (n = 3). The angioplasty catheter-based procedure allows precise fistula occlusion “like a sandwich” with the pushable Embolization Coil. Five patients with BPF sizes ranging from 0.8 to 1.5 mm were successfully treated with a pushable Embolization Coil, except for one with a BPF size of 5.8 mm. No adverse events or complications were observed throughout follow-up, ranging from 29 to 1,307 days.

Conclusion

The pushable Nester® Embolization Coil seems a minimally invasive, cost-effective, and relatively easy-to-perform bronchoscopic treatment for postoperative BPF with a size less than 2 mm. Further studies are required to ensure the use of pushable Embolization Coil in treating postoperative BPF.
The rise of Parkinson’s disease is a global challenge, but efforts to tackle this must begin at a national level: a protocol for national digital screening and “eat, move, sleep” lifestyle interventions to prevent or slow the rise of non-communicable diseases in Thailand
Authors: Bhidayasiri Roongroj , Sringean Jirada , Phumphid Saisamorn , Anan Chanawat , Thanawattano Chusak , Deoisres Suwijak , Panyakaew Pattamon , Phokaewvarangkul Onanong , Maytharakcheep Suppata , Buranasrikul Vijittra , Prasertpan Tittaya , Khontong Rotjana , Jagota Priya , Chaisongkram Araya , Jankate Worawit , Meesri Jeeranun , Chantadunga Araya , Rattanajun Piyaporn , Sutaphan Phantakarn , Jitpugdee Weerachai , Chokpatcharavate Marisa , Avihingsanon Yingyos , Sittipunt Chanchai , Sittitrai Werasit , Boonrach Grisada , Phonsrithong Aekamorn , Suvanprakorn Pichit , Vichitcholchai Janprapa , Bunnag Tej
Published: May 2024

The rising prevalence of Parkinson’s disease (PD) globally presents a significant public health challenge for national healthcare systems, particularly in low-to-middle income countries, such as Thailand, which may have insufficient resources to meet these escalating healthcare needs. There are also many undiagnosed cases of early-stage PD, a period when therapeutic interventions would have the most value and least cost. The traditional “passive” approach, whereby clinicians wait for patients with symptomatic PD to seek treatment, is inadequate. Proactive, early identification of PD will allow timely therapeutic interventions, and digital health technologies can be scaled up in the identification and early diagnosis of cases. The Parkinson’s disease risk survey (TCTR20231025005) aims to evaluate a digital population screening platform to identify undiagnosed PD cases in the Thai population. Recognizing the long prodromal phase of PD, the target demographic for screening is people aged ≥ 40 years, approximately 20 years before the usual emergence of motor symptoms. Thailand has a highly rated healthcare system with an established universal healthcare program for citizens, making it ideal for deploying a national screening program using digital technology. Designed by a multidisciplinary group of PD experts, the digital platform comprises a 20-item questionnaire about PD symptoms along with objective tests of eight digital markers: voice vowel, voice sentences, resting and postural tremor, alternate finger tapping, a “pinch-to-size” test, gait and balance, with performance recorded using a mobile application and smartphone’s sensors. Machine learning tools use the collected data to identify subjects at risk of developing, or with early signs of, PD. This article describes the selection and validation of questionnaire items and digital markers, with results showing the chosen parameters and data analysis methods to be robust, reliable, and reproducible. This digital platform could serve as a model for similar screening strategies for other non-communicable diseases in Thailand.
Chloroquine-induced DNA damage synergizes with DNA repair inhibitors causing cancer cell death
Authors: Iglesias-Corral Diego , García-Valles Paula , Arroyo-Garrapucho Nuria , Bueno-Martínez Elena , Ruiz-Robles Juan Manuel , Ovejero-Sánchez María , González-Sarmiento Rogelio , Herrero Ana Belén
Published: May 2024

Background

Cancer is a global health problem accounting for nearly one in six deaths worldwide. Conventional treatments together with new therapies have increased survival to this devastating disease. However, the persistent challenges of treatment resistance and the limited therapeutic arsenal available for specific cancer types still make research in new therapeutic strategies an urgent need.

Methods

Chloroquine was tested in combination with different drugs (Panobinostat, KU-57788 and NU-7026) in 8 human-derived cancer cells lines (colorectal: HCT116 and HT29; breast: MDA-MB-231 and HCC1937; glioblastoma: A-172 and LN-18; head and neck: CAL-33 and 32816). Drug´s effect on proliferation was tested by MTT assays and cell death was assessed by Anexin V-PI apoptosis assays. The presence of DNA double-strand breaks was analyzed by phospho-H2AX fluorescent staining. To measure homologous recombination efficiency the HR-GFP reporter was used, which allows flow cytometry-based detection of HR stimulated by I-SceI endonuclease-induced DSBs.

Results

The combination of chloroquine with any of the drugs employed displayed potent synergistic effects on apoptosis induction, with particularly pronounced efficacy observed in glioblastoma and head and neck cancer cell lines. We found that chloroquine produced DNA double strand breaks that depended on reactive oxygen species formation, whereas Panobinostat inhibited DNA double-strand breaks repair by homologous recombination. Cell death caused by chloroquine/Panobinostat combination were significantly reduced by N-Acetylcysteine, a reactive oxygen species scavenger, underscoring the pivotal role of DSB generation in CQ/LBH-induced lethality. Based on these data, we also explored the combination of CQ with KU-57788 and NU-7026, two inhibitors of the other main DSB repair pathway, nonhomologous end joining (NHEJ), and again synergistic effects on apoptosis induction were observed.

Conclusion

Our data provide a rationale for the clinical investigation of CQ in combination with DSB inhibitors for the treatment of different solid tumors.
Effects of teleworking on wellbeing from a gender perspective: a systematic review
Authors: Castro-Trancón Nereida , Zuazua-Vega Mónica , Osca Amparo , Cifre Eva , García-Izquierdo Antonio L.
Published: May 2024

Telework has been seen as a crucial tool for enhancing work-home balance, and potentially boosting employee wellbeing. However, contradictory findings highlight the necessity of integrating a gender perspective. This study aims to find out the psychosocial effects of teleworking on wellbeing from a gender perspective through a systematic review since 2010 till 2022. We used PRISMA, SPICE and PICOS models to finally select 37 studies, considering both quantitative and qualitative design perspectives. More than half of the reviewed articles (22) found that telework has negative effects on work-family interaction and work-family balance; and, as expected, these negative effects were greater for women, such as increasing dissatisfaction with work, life and free time. Studies reviewed show that women teleworkers report increased work-family conflict and traditional gender roles relating to household and family care responsibilities. We have found also that 10 studies observed positive effects of telework for both men and women, whilst five papers report both positive and negative effects on wellbeing. Lastly, we discuss the advantages and disadvantages of teleworking from a gender perspective considering the results we have found.
Effect of cold stress on photosynthetic physiological characteristics and molecular mechanism analysis in cold-resistant cotton (ZM36) seedlings
Authors: Li Youzhong , Zhu Jincheng , Xu Jianwei , Zhang Xianliang , Xie Zongming , Li Zhibo
Published: May 2024

Low temperature and cold damage seriously hinder the growth, development, and morphogenesis of cotton seedlings. However, the response mechanism of cotton seedlings under cold stress still lacks research. In this study, transcriptome sequencing, gas exchange parameters, and rapid chlorophyll fluorescence parameters were analyzed in leaves of cold-tolerant upland cotton variety “ZM36” under different temperature stress [25°C (T25, CK), 15°C (T15), 10°C (T10), and 4°C (T4)]. The results showed that the net photosynthetic rate (Pn), stomatal conductance (Gs), transpiration rate (Tr), PSII potential maximum photochemical efficiency (Fv/Fm), and performance index (PIabs) of cotton leaves significantly decreased, and the intercellular CO2 concentration (Ci) and Fo/Fm significantly increased under cold stress. The transcriptome sequencing analysis showed that a total of 13,183 DEGs were involved in the response of cotton seedlings at each temperature point (T25, T15, T10, and T4), mainly involving five metabolic pathways—the phosphatidylinositol signaling system, photosynthesis, photosynthesis antenna protein, carbon fixation in photosynthetic organisms, and carotenoid synthesis. The 1,119 transcription factors were discovered among all the DEGs. These transcription factors involve 59 families, of which 15.8% of genes in the NAC family are upregulated. Through network regulatory analysis, the five candidate genes GhUVR8 (GH_A05G3668), GhPLATZ (GH_A09G2161), GhFAD4-1 (GH_A01G0758), GhNFYA1 (GH_A02G1336), and GhFAD4-2 (GH_D01G0766) were identified in response to cold stress. Furthermore, suppressing the expression level of GhPLATZ by virus-induced gene silencing led to the reduction of low temperature resistance, implying GhPLATZ as a positive regulator of low temperature tolerance. The findings of the study revealed a piece of the complex response mechanism of the cold-tolerant variety “ZM36” to different cold stresses and excavated key candidate genes for low temperature response, which provided support for accelerating the selection and breeding of cotton varieties with low temperature tolerance.
Role of institutions in public management: developing case studies for divergent policy systems
Authors: Singh Vaishali
Published: May 2024

Public policy management has an intractable nature, and the institutional complexity of governance further exacerbates its practice. Transnational learning cutting across countries and policy areas can contribute to this policy knowledge in dealing with multifarious issues in public management. Understanding the institutional mix in public management in various contexts enhances the existing comprehension of how the national pattern of public management works differently in different socio-economic, cultural, and political settings. The present research aims to study the institutional framework in the form of state structure (unitary or federal) and the nature of executive government (majoritarian or consensual) in delineating the influence of institutions on public management processes in divergent policy systems. The paper undertakes four in-depth country case studies and the public management reforms as a response to institutional pressure are examined using the 4 M strategy–Maintain (holding on to existing administrative structures and processes), Modernize (keeping service delivery and regulation up to date), Marketize (efficiency and user-responsive public management), and Minimize (reducing state-led regulation). The case studies highlight the differences in the broad direction and energy of implementation that characterize a particular policy style. The results of the study indicate that even though the institutional dimensions are not present in strict polarization, the impact of the institutional mix is evident in the dominant strategies of public management reforms adopted at the national level.
Health effect of public sports services and public health services: empirical evidence from China
Authors: Cao Lin , Cai Jianguang , Gong Yanping , Bao Qingqing , Hu Junrong , Tang Ningxiao
Published: May 2024

There is no clear explanation for the extraordinary rebound in China’s population mortality over the past decade. This paper utilizes panel data from 31 Chinese provinces from 2010 to 2020 to determine the distinct impacts of public sports services (PSS), public health services (PMS), and their interaction on population mortality. Empirical results show that public sports services significantly reduce mortality. Every unit increase in public sports services reduces mortality by about 2.3%. It is characterized by delayed realization. Public health services were surprisingly associated with a rebound in mortality. Further studies found strong health effect from interaction of public sports and health services. The effect was significantly strengthened in areas with fewer extreme temperatures or developed economy. The findings have important policy implications for the high-quality development of public sports and health services. It also emphasizes integration of sports and medicine and mitigates health risks associated with extreme temperatures.
Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems
Authors: Arrué Patricio , Laksari Kaveh , Russo Mark , La Placa Tana , Smith Meghan , Toosizadeh Nima
Published: May 2024

Frailty is a geriatric syndrome associated with the lack of physiological reserve and consequent adverse outcomes (therapy complications and death) in older adults. Recent research has shown associations between heart rate (HR) dynamics (HR changes during physical activity) with frailty. The goal of the present study was to determine the effect of frailty on the interconnection between motor and cardiac systems during a localized upper-extremity function (UEF) test. Fifty-six individuals aged 65 or above were recruited and performed the previously developed UEF test consisting of 20-s rapid elbow flexion with the right arm. Frailty was assessed using the Fried phenotype. Wearable gyroscopes and electrocardiography were used to measure motor function and HR dynamics. In this study, the interconnection between motor (angular displacement) and cardiac (HR) performance was assessed, using convergent cross-mapping (CCM). A significantly weaker interconnection was observed among pre-frail and frail participants compared to non-frail individuals (p < 0.01, effect size = 0.81 ± 0.08). Using logistic models, pre-frailty and frailty were identified with sensitivity and specificity of 82%–89%, using motor, HR dynamics, and interconnection parameters. Findings suggested a strong association between cardiac-motor interconnection and frailty. Adding CCM parameters in a multimodal model may provide a promising measure of frailty.
Generating hyperspectral reference measurements for surface reflectance from the LANDHYPERNET and WATERHYPERNET networks
Authors: De Vis Pieter , Goyens Clemence , Hunt Samuel , Vanhellemont Quinten , Ruddick Kevin , Bialek Agnieszka
Published: May 2024

The LANDHYPERNET and WATERHYPERNET networks (which together make up the HYPERNETS network) consist of a set of autonomous hyperspectral spectroradiometers (HYPSTAR®) acquiring fiducial reference measurements of surface reflectance at various sites covering a wide range of surface types (both land and water) for use in satellite Earth observation validation and remote sensing applications. This paper describes the processing algorithm for the HYPSTAR® data products. The hypernets_processor is a Python software package to process the LANDHYPERNET and WATERHYPERNET in-situ hyperspectral raw data, collected from the measurement network under the standard measurement protocols, to the designated products, through data transmission and conversion, application of calibration, evaluation of reflectance and other variables, and, archiving for distribution to users. In order to achieve fiducial reference measurement quality, uncertainties are propagated through each step of the processing chain, taking into account temporal and spectral error-covariance. Such detailed uncertainty information is unique for any satellite validation network. We also describe the HYPSTAR® products acquired until 2023–04–31, consisting of 12,190 LANDHYPERNET sequences and 55,514 WATERHYPERNET sequences (of which respectively 11,802 and 44,412 were successfully processed to surface reflectance).
Assessing the equilibrium of food supply and demand in China’s food security framework: a comprehensive evaluation, 1980–2017
Authors: Wei Yujun , Fang Dan , Wei Xiaokun , Ye Zhonghua
Published: May 2024

The continuous upward trajectory observed in total grain production serves as a fundamental pillar for guaranteeing food security. Nevertheless, relying solely on the measurement of China’s overall food security status through total grain output is inherently biased and neglects to capture the comprehensive nature of food security. This study adopts a food supply and demand balance perspective and constructs an evaluation indicator system for food security based on indicators such as grain yield per unit area, per capita grain possession, grain inventory, and inventory ratio. The weight of each indicator in the food security system is calculated using the entropy value method, and a comprehensive evaluation of China’s food security level from 1980 to 2017 is conducted. The study revealed that China’s food supply and demand exhibited a discernible upward trajectory in development. Notably, the food supply demonstrated greater volatility, whereas the food demand remained relatively stable but experienced incremental growth. Between approximately 1985 and 1993, China’s food supply and demand subsystem briefly experienced a state of mild imbalance, followed by a state of moderate imbalance around 2003. These imbalances were primarily attributed to insufficient effective food supply. In terms of the equilibrium between supply and demand in the context of food security, China’s food supply and demand exhibit a predominantly balanced condition with a slight surplus, wherein the adequacy of food supply significantly influences food security. Furthermore, the provision of policy support serves as a robust assurance for food security, and China’s existing policy framework for food security demonstrates a constructive impact.
Short-term residual effects of occasional tillage on crop performance, soil water, and water-use efficiency in a 10-year no-till system under a dry Mediterranean climate
Authors: Diop Massamba , Beniaich Adnane , Cicek Harun , Ouabbou Hassan , Bamouh Ahmed , El Gharras Oussama , Dahan Rachid , Zine El Abidine Aziz , El Gharous Mohamed , El Mejahed Khalil
Published: May 2024

Conservation Agriculture is a farming system based on no mechanical soil disturbance, permanent soil cover, and crop diversification. A study was carried out in an on-farm field trial set up in Meknes (Morocco) under a long-term no-till (NT) system to evaluate the residual effect of one-time occasional tillage (OT) on crop performance, soil water, and water-use efficiency (WUE) one and two years after OT implementation. Shallow and deep options of OT were compared with common NT practices (with crop residue retention and with crop residue removal) for two consecutive seasons of 2021–2022 (year 1) and 2022–2023 (year 2). The four tillage practices were implemented in November 2020. Three crops were studied each year: durum wheat (Triticum durum), faba bean (Vicia faba minor), and chickpea (Cicer arietinum) all grown under NT in both the years and arranged in four crop rotations. Our findings show that grain yield of wheat and chickpea was negatively affected by OT for all years considered. In wheat, there was a grain yield loss of 18 and 20% for shallow and deep OT, respectively compared to NT with crop residue retention. In chickpea, the grain yield loss was as high as 47 and 49% for shallow and deep OT, respectively. Average soil water storage measured at 0–60 cm at sowing was also lower in deep OT (133 mm) compared to NT with crop residue retention (151 mm) for all years and rotations considered. Yet, in wheat year 1, deep OT slightly improved soil water content at 30 cm depth compared to NT treatments. The comparison of WUE between treatments showed that, under NT with crop residue retention, the crops produced more grain and aboveground biomass per mm of water. Wheat/faba bean rotation had a greater grain yield and WUE (all years considered) and overall greater soil water content (year 1), compared to the wheat/chickpea rotation. The results suggest that the effects of OT on crop performance and water productivity in the short term can be adverse. On the other hand, grain yield of wheat can be improved by a judicious choice of legume to be used as a preceding crop.
Simultaneous construction strategy using two types of fluorescent markers for HVT vector vaccine against infectious bursal disease and H9N2 avian influenza virus by NHEJ-CRISPR/Cas9
Authors: Zhang Jun-Feng , Shang Ke , Kim Sang-Won , Park Jong-Yeol , Wei Bai , Jang Hyung-Kwan , Kang Min , Cha Se-Yeoun
Published: May 2024

Recently, herpesvirus of turkeys (HVT), which was initially employed as a vaccine against Marek’s disease (MD), has been shown to be a highly effective viral vector for producing recombinant vaccines that can simultaneously express the protective antigens of multiple poultry diseases. Prior to the development of commercial HVT-vectored dual-insert vaccines, the majority of HVT-vectored vaccines in use only contained a single foreign gene and were often generated using time-consuming and inefficient traditional recombination methods. The development of multivalent HVT-vectored vaccines that induce simultaneous protection against several avian diseases is of great value. In particular, efficacy interference between individual recombinant HVT vaccines can be avoided. Herein, we demonstrated the use of CRISPR/Cas9 gene editing technology for the insertion of an IBDV (G2d) VP2 expression cassette into the UL45/46 region of the recombinant rHVT-HA viral genome to generate the dual insert rHVT-VP2-HA recombinant vaccine. The efficacy of this recombinant virus was also evaluated in specific pathogen-free (SPF) chickens. PCR and sequencing results showed that the recombinant virus rHVT-VP2-HA was successfully constructed. Vaccination with rHVT-VP2-HA produced high levels of specific antibodies against IBDV (G2d) and H9N2/Y280. rHVT-VP2-HA can provide 100% protection against challenges with IBDV (G2d) and H9N2/Y280. These results demonstrate that rHVT-VP2-HA is a safe and highly efficacious vaccine for the simultaneous control of IBDV (G2d) and H9N2/Y280.
Study of Self-Excited Thermomechanical Oscillator with Shape Memory Alloys
Authors: Yotov Ivo , Todorov Georgi , Todorov Todor
Published: May 2024

In this paper, a new type of self-excited thermomechanical oscillator containing an oscillating shape memory alloy (SMA) filament with two symmetrically arranged spheres is investigated. The self-excitation of the oscillations is due to a heater of constant temperature, which causes periodic contractions of the filament when it approaches it. The contracted filament moves away from the heater a distance sufficient to cool it. Under the action of the weight of the spheres, the cooled filament re-approaches the heater, causing the above processes to repeat periodically. On the basis of experimental studies, approximating functions of the heater’s heat field distribution are derived. A dynamic model of the oscillator has been created, in which the minor and major hysteresis in the SMA alloy and the distribution of the heat field around the heater have been taken into account. Through numerical solutions of the differential equations, the laws of motion of the spheres are obtained. The displacements of the spheres in two perpendicular directions were measured using an experimental system. The obtained experimental results validate the proposed dynamic model and its assumptions with a high degree of confidence. Conclusions are drawn about the stochastic nature of the oscillations due to the hysteresis properties of the SMA and the temperature variation of the natural frequency of the oscillating system.
Overvoltage Avoidance Control Strategy for Braking Process of Brushless DC Motor Drives with Small DC-Link Capacitance
Authors: Chen Wei , Wu Jialong , Li Xinmin , Li Chen
Published: May 2024

Single-phase input rectifier brushless DC motor drives with a small film capacitor have many advantages, such as high power density and high reliability. However, when the motor system operates in regenerative braking mode, the dc-link capacitor with reduced capacitance may suffer from overvoltage without adding additional hardware circuits. At the same time, the braking torque control of the motor will be affected by speed variations. In order to ensure smooth and reliable operation of the motor system, an anti-overvoltage braking torque control method is proposed in this article. The relationship among the dc-link capacitance, the dc-link capacitor voltage, and the speed during regenerative braking is analyzed quantitatively, and the speed at which the regenerative braking is switched to the plug braking is obtained, which in turn consumes the capacitor energy to avoid dc-link overvoltage. Additionally, based on the relationship between the controllability of the braking torque and the speed, a reference value of the braking current that matches the speed is designed. The proposed method makes use of the capacitor’s energy storage during regenerative braking. Meanwhile, it mitigates the impact of motor speed on braking torque. Finally, the effectiveness of the proposed method is verified on a motor platform equipped with the dc-link film capacitor.
A Survey of Flow Field and Combustion Characteristics under Subatmospheric Pressure
Authors: Ding Guoyu , Yao Zhaohui , Zhu Zhixiang , Huang Yakun
Published: May 2024

This paper presents a summary of and introduction to research on high-altitude and subatmospheric combustion concerning turbine and scramjet engines. The investigation includes theoretical analysis, experimental studies, and numerical simulations. The analysis encompasses the flow field structure, fuel atomization, and combustion performance. Subsequently, recent research on the combustion performance of liquid fuels, solid fuels, and gaseous fuels under high-altitude and low-pressure plateau environments is reviewed. This includes an evaluation of flame height, flame temperature, combustion rate, fire spread rate, and heat radiation flux. Additionally, combustion performance prediction models for high-altitude environments based on experimental and theoretical analysis have been introduced. Lastly, issues in subatmospheric combustion in the aerospace and plateau fire fields are presented based on the current research.
A New Closed-Form Formula of the Gauss Hypergeometric Function at Specific Arguments
Authors: Li Yue-Wu , Qi Feng
Published: May 2024

In this paper, the authors briefly review some closed-form formulas of the Gauss hypergeometric function at specific arguments, alternatively prove four of these formulas, newly extend a closed-form formula of the Gauss hypergeometric function at some specific arguments, successfully apply a special case of the newly extended closed-form formula to derive an alternative form for the Maclaurin power series expansion of the Wilf function, and discover two novel increasing rational approximations to a quarter of the circular constant.
A C0 Nonconforming Virtual Element Method for the Kirchhoff Plate Obstacle Problem
Authors: Wu Bangmin , Qiu Jiali
Published: May 2024

This paper investigates a novel C0 nonconforming virtual element method (VEM) for solving the Kirchhoff plate obstacle problem, which is described by a fourth-order variational inequality (VI) of the first kind. In our study, we distinguish our approach by introducing new internal degrees of freedom to the traditional lowest-order C0 nonconforming VEM, which originally lacked such degrees. This addition not only facilitates error estimation but also enhances its intuitiveness. Importantly, our novel C0 nonconforming VEM naturally satisfies the constraints of the obstacle problem. We then establish an a priori error estimate for our novel C0 nonconforming VEM, with the result indicating that the lowest order of our method achieves optimal convergence. Finally, we present a numerical example to validate the theoretical result.
Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis
Authors: Arakil Nour , Akhund Shahid Akhtar , Elaasser Basant , Mohammad Khalid S.
Published: May 2024

The phenomenon of bone metastases presents a significant challenge within the context of advanced cancer treatments, particularly pertaining to breast, prostate, and lung cancers. These metastatic occurrences stem from the dissemination of cancerous cells into the bone, thereby interrupting the equilibrium between osteoblasts and osteoclasts. Such disruption results in skeletal complications, adversely affecting patient morbidity and quality of life. This review discusses the intricate interplay between cancer cells and the bone microenvironment, positing the bone not merely as a passive recipient of metastatic cells but as an active contributor to cancer progression through its distinctive biochemical and cellular makeup. A thorough examination of bone structure and the dynamics of bone remodeling is undertaken, elucidating how metastatic cancer cells exploit these processes. This review explores the genetic and molecular pathways that underpin the onset and development of bone metastases. Particular emphasis is placed on the roles of cytokines and growth factors in facilitating osteoclastogenesis and influencing osteoblast activity. Additionally, this paper offers a meticulous critique of current diagnostic methodologies, ranging from conventional radiography to advanced molecular imaging techniques, and discusses the implications of a nuanced understanding of bone metastasis biology for therapeutic intervention. This includes the development of targeted therapies and strategies for managing bone pain and other skeletal-related events. Moreover, this review underscores the imperative of ongoing research efforts aimed at identifying novel therapeutic targets and refining management approaches for bone metastases. It advocates for a multidisciplinary strategy that integrates advancements in medical oncology and radiology with insights derived from molecular biology and genetics, to enhance prognostic outcomes and the quality of life for patients afflicted by this debilitating condition. In summary, bone metastases constitute a complex issue that demands a comprehensive and informed approach to treatment. This article contributes to the ongoing discourse by consolidating existing knowledge and identifying avenues for future investigation, with the overarching objective of ameliorating patient care in the domain of oncology.
Unraveling TAFRO Syndrome: An In-Depth Look at the Pathophysiology, Management, and Future Perspectives
Authors: Caballero Juan Carlos , Conejero Nazaret , Solan Laura , Diaz de la Pinta Francisco Javier , Cordoba Raul , Lopez-Garcia Alberto
Published: May 2024

TAFRO syndrome is a rare and aggressive inflammatory entity characterized by thrombocytopenia, anasarca, fever, renal failure, reticulin fibrosis, and organomegaly. This entity supposes a diagnostic and therapeutic challenge due to its significant overlap with Castleman’s disease. However, distinct clinical and histological features warrant its classification as a separate subtype of idiopathic multicentric Castleman’s disease (iMCD). While recent modifications have been made to the diagnostic criteria for iMCD, these criteria lack specificity for this particular condition, further complicating diagnosis. Due to its inflammatory nature, several complex molecular signaling pathways are involved, including the JAK-STAT pathway, NF-kB, and signal amplifiers such as IL-6 and VEGF. Understanding the involvement of immune dysfunction, some infectious agents, genetic mutations, and specific molecular and signaling pathways could improve the knowledge and management of the condition, leading to effective treatment strategies. The current therapeutic approaches include corticosteroids, anti-IL6 drugs, rituximab, and chemotherapy, among others, but response rates vary, highlighting the need for personalized strategies. The prognosis is uncertain due to diagnostic difficulties, emphasizing the importance of early intervention and appropriate targeted treatment. This comprehensive review examines the evolving landscape of TAFRO syndrome, including the pathophysiology, diagnostic criteria, treatment strategies, prognosis, and future perspectives.
Redefining Surgical Materials: Applications of Silk Fibroin in Osteofixation and Fracture Repair
Authors: Foppiani Jose A. , Taritsa Iulianna C. , Foster Lacey , Patel Armaan , Hernandez Alvarez Angelica , Lee Daniela , Lin Gavin J. , Lee Theodore C. , Gavlasova Dominika , Escobar-Domingo Maria J. , Kaplan David L. , Lin Samuel J.
Published: May 2024

Silk and silk derivatives have emerged as a possible alternative in surgical device development, offering mechanical strength, biocompatibility, and environmental sustainability. Through a systematic review following PRISMA guidelines, this study evaluated silk fibroin’s application across pre-clinical and clinical settings, focusing on its role as screws and plates for osteofixation. A comprehensive search yielded 245 studies, with 33 subjected to full-text review and 15 ultimately included for qualitative analysis. The findings underscore silk fibroin’s superior properties, including its tunable degradation rates and ability to be functionalized with therapeutic agents. In vivo and in vitro studies demonstrated its efficacy in enhancing bone healing, offering improved outcomes in osteofixation, particularly for craniofacial defects. Silk fibroin’s remarkable attributes in biodegradation and drug release capabilities underscore its potential to enhance patient care. Ultimately, silk fibroin’s integration into surgical practices promises a revolution in patient outcomes and environmental sustainability. Its versatility, coupled with the continuous progress in fabrication techniques, signals a promising horizon for its widespread acceptance in the medical field, potentially establishing a new benchmark in surgical treatment. Further research is expected to solidify the transition of silk products from basic science to patient care, paving the way for widespread use in various surgical applications.