bluuebunny/crossref_metadata_2025 huggingface dataset:
Background and Foreground: Connections and Distinctions When Health Professions Faculty Teach Both Interprofessional Collaborative Practice and Quality Improvement—A Case Study
Authors: Stevenson Katherine , Thor Johan , D’Eon Marcel , Headrick Linda A , Andersson Gäre Boel
Published: February 2025

OBJECTIVES

Despite decades of effort, programs continue to struggle to integrate competencies related quality improvement (QI) and interprofessional collaborative practice (ICP) into health professions education. Additionally, while QI and ICP may seem intuitively linked and there exists some examples of a coordinated approach, the literature regarding competencies, including knowledge, skills, and attitudes (KSAs), is still largely focused on QI and ICP as separate fields of knowledge and practice. This study explored distinctions and connections between quality improvement (QI) and interprofessional collaborative practice (ICP) competency domains in health professions education.

METHODS

The authors used a qualitative case study approach with an instrumental case, that is, the University of Missouri-Columbia (MU), where QI and ICP were intentionally integrated as part of core curricula in health professional schools and programs. Eleven faculty members from medicine, nursing, pharmacy, and health care administration participated in interviews exploring their teaching choices in either classroom or clinical settings.

RESULTS

Study participants defined the goal of teaching QI and ICP as enabling learners to deliver safe and patient-centered care and described the knowledge and skills required for QI and the attitudes and skills required for ICP. Furthermore, they described the relationship between QI and ICP as one mediated by systems thinking, where ICP is backgrounded as a critical pre-requisite and QI is foregrounded as a vector for developing interprofessional competencies.

CONCLUSIONS

The MU case elucidates the potential synergies that occur when faculty address quality improvement and interprofessional collaborative practice competencies with an integrated approach that leverages connections, while also respecting distinctions. For health professions education programs looking to improve the effectiveness and efficiency of their curricular approach to these fields, it may be fruitful to consider ICP as background and QI as foreground, remembering that without each other, ICP risks losing meaning and QI risks losing impact.
Dermatofibrosarcoma Protuberans and SMARCA4/BRG1 Loss: Novel Molecular Change or Coincidental Association?
Authors: Deng Huiyan , Li Mingyang , Jia Ying , Jiang Hanxu , Jia Keqi , Fan Xiaojie , Liu Yueping
Published: February 2025

Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing soft tissue sarcoma of the skin, representing less than 1% of all soft tissue sarcomas. Clinically, it is characterized by its indolent nature, localized growth, and low-grade malignant fibrosarcoma features. Here, we present a case of a 40-year-old woman diagnosed with DFSP carrying a deletion in the SMARCA4 gene. Following complete tumour resection, no recurrence or new malignancies were observed during the 1-year follow-up period. To our knowledge, cases of DFSP with SMARCA4 gene deletions have not been previously documented in the literature. This case contributes to our understanding of the molecular mechanisms underlying DFSP in soft tissue sarcomas, potentially enhancing clinicians’ ability to accurately assess patient prognoses.
Hydrological, geochemical and microbiological controls on iron mineralisation in an intermittent stream
Authors: Stevenson Zackry , Riddley Mia , McConnell Tamara , Swanner Elizabeth D.
Published: February 2025

In Clear Creek, which runs through the Iowa State University campus in Ames, Iowa, USA, several types of iron mineralisation occur within stagnant pools and slow-moving water. This includes rusty flocs, commonly observed in mineral springs, rust-stained sediments and iridescent films (‘schwimmeisen’) on the pool surfaces. Observations of iron mineralisation over the course of more than a year in a single reach indicated that mineralisation occurred after precipitation events once water levels in the stream had dropped. Iron extracted and quantified from Clear Creek sediments and pool waters indicated the stream and its sediments were unlikely to be supplying the iron for mineralisation. We hypothesise that the observed mineralisation could result from the discharge of shallow, reducing groundwater-bearing Fe(II) into stagnant pools that form in debris-dammed areas of the stream. Piezometers installed next to the creek documented that shallow groundwater contained dissolved Fe, with the source of Fe being the floodplain sediments and the hydraulic gradient promoted groundwater discharge into the stream. Microorganisms identified in mineralised pools using 16S rRNA amplicon sequencing revealed an elevated presence of putative iron-oxidizing and iron-reducing microorganisms in mineralised vs. non-mineralised pools. Further investigation of the iridescent films revealed them to be composed of amorphous Fe(III) minerals. We further hypothesise that microbial exudates reduce surface tension and potential micro-zones for subsequent microbial iron redox cycling with dissolved organic matter in the pools. Determining the processes controlling mineralisation can lead to a better understanding of the ecological role of iron mineralisation in agricultural watersheds and the importance of contaminant degradation and nutrient cycling.
Comparative effectiveness of short-term psychodynamic psychotherapy and cognitive behavioral therapy for major depression in psychiatric outpatient clinics: a randomized controlled trial
Authors: Malkomsen Anders , Wilberg Theresa , Bull-Hansen Bente , Dammen Toril , Evensen Julie Horgen , Hummelen Benjamin , Løvgren André , Osnes Kåre , Ulberg Randi , Røssberg Jan Ivar
Published: February 2025

Background

More studies with low risk of bias on the effectiveness of cognitive behavioral therapy (CBT) and short-term psychodynamic psychotherapy (STPP) for major depressive disorder (MDD) are needed. This study compares the outcome of CBT and STPP and examines the improvements in each treatment, focusing on effect sizes, reliable change, dropout rates, and remission rates, using broad inclusion criteria (e.g. participants using antidepressants or with strong suicidal ideation).

Methods

One hundred patients were randomly allocated to CBT or STPP. All patients were offered either 16 weekly sessions followed by 3 monthly booster sessions in CBT, or 28 weekly sessions in STPP. Primary outcome measures were Hamilton Depression Rating Scale (HDRS) and Beck’s Depression Inventory-II (BDI-II). Secondary outcome measures were Work and Social Adjustment Scale (WSAS), Generalized Anxiety Disorder-7 (GAD-7), Global Assessment of Functioning (GAF) and Short Form Health Survey-12 (SF-12).

Results

No significant differences in outcomes were found between the two treatment groups on any of the measures. The within-group effects were large (> 0.8) for the primary outcome measures and moderate to large for the secondary outcome measures. According to the reliable change index (RCI), 79% of patients reliably improved on HDRS and 76% improved on BDI-II, whereas respectively 6% and 10% reliably deteriorated.

Conclusions

These findings support the assumption that CBT and STPP are equally effective treatments for patients with depressive disorders in psychiatric outpatient clinics. Additionally, they strengthen the evidence for the effectiveness of both CBT and STPP in these settings, while also highlighting that not all depressed patients respond to short-term treatment.

Clinical trial registration

Clinical Trial gov. Identifier: NCT03022071. Date of registration: 2016-11-14.
The impact of C216T and hot spot mutations of the TERT promoter on the clinicopathologic characteristics and S100A10 expression in papillary thyroid carcinoma: a comparative study
Authors: Li Ping , Huang Chuqiang , Liu Xiaoling , Gui Huihui , Li Jian
Published: February 2025

Objective

The C216T mutation in the TERT promoter (TERTp) is a rarely reported genetic alteration in papillary thyroid carcinoma (PTC). Its clinical significance remains unclear. This study aimed to compare the impact of the C216T and hot spot mutations (C228T and C250T) of TERTp on the clinicopathologic characteristics and the expression of S100A10, a member of the S100 protein family, in PTC.

Methods

In this retrospective study, a cohort comprising 8 PTC cases with the C216T mutation, 12 cases with the hot spot mutations, and 120 cases with the wildtype genotype was established. The influence of TERTp mutations on the clinicopathologic profiles of PTC was assessed.

Results

The C216T mutation was mutually exclusive with the hot spot mutations and its frequency (0.19%) fell between that of C228T (0.68%) and C250T (0.06%). Compared to PTC cases with the wildtype genotype, cases with C216T mutations did not exhibit significant differences in clinicopathologic characteristics and S100A10 expression levels. In contrast, the hot spot mutations were positively associated with extrathyroidal extension (p = 0.001), ATA recurrence risk (p < 0.001), AJCC staging (p < 0.001), and increased expression of S100A10 (p = 0.005). Furthermore, a significant correlation was found between S100A10 expression and extrathyroidal extension (p = 0.005), lymph node metastasis (p = 0.013), and ATA recurrence risk (p = 0.023).

Conclusion

The C216T mutation did not induce the aggressiveness of PTC as the hot spot mutations did. Furthermore, the hot spot mutations were closely associated with the increased expression of S100A10. The latter may contribute to the pro-invasive effect of the hot spot mutations on PTC.
Progress in multi-omics studies of osteoarthritis
Authors: Wei Yuanyuan , Qian He , Zhang Xiaoyu , Wang Jian , Yan Heguo , Xiao Niqin , Zeng Sanjin , Chen Bingbing , Yang Qianqian , Lu Hongting , Xie Jing , Xie Zhaohu , Qin Dongdong , Li Zhaofu
Published: February 2025

Osteoarthritis (OA), a ubiquitous degenerative joint disorder, is marked by pain and disability, profoundly impacting patients' quality of life. As the population ages, the global prevalence of OA is escalating. Omics technologies have become instrumental in investigating complex diseases like OA, offering comprehensive insights into its pathogenesis and progression by uncovering disease-specific alterations across genomics, transcriptomics, proteomics, and metabolomics levels. In this review, we systematically analyzed and summarized the application and recent achievements of omics technologies in OA research by scouring relevant literature in databases such as PubMed. These studies have shed light on new potential therapeutic targets and biomarkers, charting fresh avenues for OA diagnosis and treatment. Furthermore, in our discussion, we highlighted the immense potential of spatial omics technologies in unraveling the molecular mechanisms of OA and in the development of novel therapeutic strategies, proposing future research directions and challenges. Collectively, this study encapsulates the pivotal advances in current OA research and prospects for future investigation, providing invaluable references for a deeper understanding and treatment of OA. This review aims to synthesize the recent progress of omics technologies in the realm of OA, aspiring to furnish theoretical foundations and research orientations for more profound studies of OA in the future.
Facility-Level Disparities in Radiation Use for Limited-Stage Small Cell Lung Cancer
Authors: Tsekouras Ian T. , Hotsinpiller Whitney S. , Bonner James A. , Kole Adam J.
Published: February 2025

PURPOSE

Treatment of limited-stage small cell lung cancer (LS-SCLC) with twice-a-day radiation therapy (RT) has remained the standard of care for many decades. Growing evidence suggests that outcomes with dose escalated twice-a-day RT may further improve outcomes. However, once-daily treatment remains common. The purpose of this study was to evaluate individual treatment facilities for utilization of twice-a-day RT.

METHODS

Patients with LS-SCLC treated with definitive chemoradiation from 2004 to 2019 were identified in the National Cancer Database. RT was classified as twice-a-day (45 Gy in 30 fractions) or once-daily (59.4-70.2 Gy in 30-39 fractions). Patients were excluded if surgery was performed. All patients received doublet chemotherapy. Unique treatment facilities delivering at least one twice-a-day treatment course during the study period were classified as BID-treating. Facilities not delivering any twice-a-day RT were classified as QD-only. The proportion of QD-only facilities was identified. Facility-level characteristics associated with QD-only classification were analyzed.

RESULTS

A total of 22,362 patients with LS-SCLC were treated at 1,222 unique facilities. A slight majority of facilities (n = 644, 52.7%) were BID-treating, whereas fewer (n = 578, 47.3%) were QD-only. A total of 73.9% of academic facilities were BID-treating versus 48.3% of nonacademic facility types (
P
< .001). Only 20.7% of low volume treatment facilities (lowest quartile of patients with LS-SCLC treated) used twice-a-day fractionation versus 78.2% of the highest quartile volume facilities (
P
< .001). On multivariable analysis, academic and high-volume facilities were statistically significantly associated with BID-treating classification (adjusted odds ratio, 2.5 [
P
< .001] and 4.2 [
P
< .001], respectively).

CONCLUSION

Nearly half of facilities treating LS-SCLC with definitive chemoradiation do not use twice-a-day fractionation schedules despite ongoing and growing evidence of superiority to once-daily fractionation. High-volume, academic facilities were more likely to offer twice-a-day fractionation.
Effects of Heating on Tendon Mechanical Properties and Performance during Stretch-Shortening Cycle Exercises
Authors: Sasajima Shuhei , Kubo Keitaro
Published: February 2025

Purpose

The purpose of this study was to investigate the effects of heating on Achilles tendon mechanical properties (elongation, elastic energy, and hysteresis) and performance during stretch-shortening cycle exercise (pre-stretch augmentation and efficiency).

Methods

Fifteen males participated in this study. Before and after heating (30 min) and non-heating (control) conditions, the mechanical properties of the Achilles tendon during ramp and ballistic contractions and two kinds of jumps (no-countermovement and countermovement jumps) were measured. In addition, electromyographic activities of the plantar flexor muscles (medial gastrocnemius, lateral gastrocnemius, and soleus muscles) and oxygen consumption were measured during 5 min of submaximal repetitive jumps after both interventions (heating and control).

Results

Although no changes in tendon elongation at all force levels and elastic energy during ramp and ballistic contractions were observed, tendon hysteresis decreased by 14.2% during ramp contraction (p = 0.015 according to the paired t-test) and 8.0% during ballistic contraction (p = 0.006 according to the paired t-test) after heating. No changes in no-countermovement and countermovement jump heights were found after both interventions. The electromyographic activities of gastrocnemius muscles at the first half and soleus muscle at all time points were significantly lower for heating than for control conditions. No difference in oxygen consumption was found between heating and control conditions.

Conclusions

These results suggest that heating reduces tendon hysteresis and enhances efficiency (assessed by electromyographic activity) during repetitive submaximal jumps.
On non-monotonic knowledge representation
Authors: Μήτσικας Θεόδωρος
Published: February 2025

H διατριβή εμβαθύνει στη μη μονοτονική αναπαράσταση γνώσης, επικεντρώνοντας σε διάφορους φορμαλισμούς, στις πρακτικές εφαρμογές, καθώς και στη διαλειτουργικότητα μεταξύ συστημάτων που χρησιμοποιούν μη μονοτονική αναπαράσταση γνώσης. Το πρώτο μέρος εξετάζει ένα φορμαλισμό που βασίζεται σε μη μονοτονικές προτάσεις, παρόμοιες με τις προτάσεις Horn, που ονομάζονται Scenario-Based Preferences. Ο μη μονοτονικός αυτός φορμαλισμός μελετάται περαιτέρω και ορίζονται οι τυπικές ιδιότητές του, οδηγώντας στη θεωρητική θεμελίωση ενός συλλογιστικού συστήματος, καθώς και σε πρωτότυπες υλοποιήσεις του. Επίσης, έχοντας ως βάση τον φορμαλισμό αυτό, αναλύεται μια μεθοδολογία για τη μετάφραση οδηγιών και πολιτικών που δίνονται από τον χρήστη σε φυσική γλώσσα, σε ένα μη μονοτονικό φορμαλισμό. Αυτή η διαδικασία περιλαμβάνει τον ορισμό μιας μεταγραφής από γλωσσικές και συντακτικές δομές σε συμβολική αναπαράσταση, μεταφράζοντας συντακτικές δομές σε προτάσεις, μαζί με τους αντίστοιχους όρους τους, για την εξαγωγή της συμβολικής πληροφορίας που αυτές περιέχουν. Αυτά τα σενάρια συνδυάζονται στη συνέχεια για την ανάπτυξη και παραγωγή θεωριών της Λογικής της Επιχειρηματολογίας. Το δεύτερο μέρος ασχολείται με την επέκταση της γλώσσας ανταλλαγής κανόνων και συλλογιστικής PSOA RuleML και της πρότυπης υλοποίησής της, PSOATransRun, με υποστήριξη της "άρνησης ως αποτυχία". Αυτή η επέκταση ενισχύει την εκφραστικότητα της γλώσσας σε όλες τις διαστάσεις των ατομικών τύπων της, δηλαδή για ατομικούς τύπους σχεσιακούς ή/και με "πλαίσια", με αναγνωριστικό ή χωρίς, ενώ οι σχέσεις και τα πλαίσια μπορεί να είναι εξαρτημένες ή ανεξάρτητες από το κατηγόρημα. Η υλοποίηση συμπληρώνεται με μελέτες περίπτωσης που βασίζονται στην άρνηση ως αποτυχία, καθώς και μια επιπρόσθετη αξιολόγηση της εφαρμογής της άρνησης ως αποτυχία για τους πολυδιάστατους ατομικούς τύπους της συγκεκριμένης γλώσσας, καθώς και για οποιονδήποτε τύπο που τους περιέχει. Το τελευταίο μέρος ασχολείται με το μοντελοποίηση μελετών περίπτωσης σύμφωνες με τον Γενικό Κανονισμό για την Προστασία Δεδομένων της Ευρωπαϊκής Ένωσης, που περιλαμβάνουν δυναμικά νομικά σενάρια. Τα παρουσιαζόμενα σενάρια απαιτούν μια μορφή αναπαράστασης που μπορεί να μεταφέρει αποτελεσματικά τη δυναμική φύση και τις αλληλεπιδράσεις που συμβαίνουν μεταξύ διαφορετικών οντοτήτων. Η υλοποίηση χρησιμοποιεί μη μονοτονικές μεταβάσεις καταστάσεων και ανταλλαγή μηνυμάτων για να προσομοιώσει την αλληλεπίδραση μεταξύ των δρώντων οντοτήτων. Επιπλέον, η ίδια μεθοδολογία χρησιμοποιείται για την υλοποίηση ενός υποσυστήματος που εκτελεί τις εντολές που λαμβάνει ως μέρος ενός ευρύτερου συστήματος που θέτει ένα νομικό και ηθικό πλαίσιο για τη μεταφορά και την επεξεργασία δεδομένων, ενσωματωμένου σε ένα διακομιστή που παρέχει επίσης ένα στοιχείο οπτικοποίησης. Συζητείται η υλοποίηση, η διαλειτουργικότητα και η αρχιτεκτονική του.
Experiments and Science Education
Authors: Κώτσης Κωνσταντίνος Θ. , Στύλος Γεώργιος
Published: February 2025

The anniversary volume “Experiments and Science Education” is published in honor of the 40th anniversary of the Department of Primary Education of the University of Ioannina, capturing the evolution of education in Natural Sciences. The book highlights the importance of experimentation in teaching, as Science is based on empirical research. Historically, teaching was based on teacher demonstrations, but now student-centered approaches and interactive experiments have improved learning. An important development is the integration of new technologies, such as simulations, virtual laboratories, and artificial intelligence, which make learning through experiments more accessible. The volume's authors, Greek university professors, and researchers, explore strategies for integrating experiments at all educational levels, underlining the importance of teacher training. The book is a valuable tool for educators, researchers, and educational policymakers, promoting the continuous development of scientific thinking through experimental investigation.
Green Trust and Environmental Concern's Influence on Gen Z's Organic Food Consumption:
Authors: Agarwal Neeraj , Chamoli Abhay , Tariyal Amit , Gupta Shiv Kumar
Published: February 2025

This study looks at how Consumption Values (CVs) affect Gen Z tourists' intentions to buy organic food. It also examines how Environmental Concerns (EC) act as a mediator and the moderating role of Green Trust (GT) in the relationship. The study analysed data from 550 Gen Z tourists using structural equation modelling (SEM) in SPSS 26 to investigate the links between CVs, EC, and OFPI. At the same time, moderation analysis was conducted through PROCESS Macro to examine the role of GT. The findings reveal that CVs significantly influence OFPI, with EC playing a mediating role and Green Trust (GT) influencing the strength of the relationship between EC and OFPI. The practical implications for marketers and policymakers include emphasising both the utilitarian and socio-emotional benefits of organic food consumption to engage Gen Z tourists effectively. Fostering Green Trust can further enhance sustainable behaviour, making it crucial for businesses to build trust around environmentally friendly practices. This research deepens the understanding of sustainable consumption behaviours and aids in developing models to guide future interventions promoting sustainable tourism choices.
NEW METHOD FOR TREATING THE SUBCLINICAL MASTITIS IN COWS
Authors: Vardanyan Albert V. , Nikoghosyan Erik A. , Grigoryan Liana H. , Sukiasyan Karine A. , Grigoryan Valery V. , Hakobyan Anush R. , Melkonyan Zhanna S.
Published: February 2025

Background. Given the prevalence of subclinical mastitis in dairy livestock as well as the numerous available methods for treatment which are not always effective, it is an urgent problem for Veterinary Medicine to develop a new, improved and effective method for treatment of this disease.
Purpose. The purpose of this research is to develop a new method for treatment of subclinical mastitis in cows by using the broad-spectrum antibiotics and immunostimulating agents.
Material and methods. We used the California mastitis test to perform the somatic cell count for identification of latent mastitis in the livestock under examination. We carry out microbiological study of the milk taken from affected cows in order to determine the composition of pathogenic microflora species as well as the sensitivity of milk microflora to various antibiotic drugs.
Based on the analogues, we formed two groups, each of 10 animals. The control group of animals was treated with Mastisan and with Bicillin-3. The experimental group was treated with ASD-2, Marfloxin, Masticef, and Dimexide. Before and during treatment, we examined morphological and biochemical parameters of blood of sick animals.
Results. In the experimental group, recovery of morphological and biochemical parameters of blood started on the 2nd day of treatment already, and it completed by the 6th day. By that day, all biochemical parameters of blood were within the normal limits; while in the control group the same parameters recovered more slowly.
Conclusion. Timely diagnosis of subclinical mastitis enables its effective treatment and prevents development of overt mastitis.
The use of antibacterial drugs  with immunostimulating agents increases the effectiveness of treatment of subclinical mastitis. Treatment of subclinical mastitis by using Marfloxin, Masticef, ASD-2 and Dimexide can reduce the duration of treatment by 2-3 days.
Sponsorship statement. This work is performed in accordance with the decree of the Government of the Republic of Armenia on base funding of scientific topics in Armenia.
DEVELOPMENT OF PCR KITS FOR BACTERIA OF THE GENUS CLOSTRIDIUM AND TOXINOTYPES CL. PERFRINGENS IDENTIFICATION
Authors: Bezborodova Natalia A. , Martynov Nikolai A. , Shilova Evgenia N. , Zubareva Vladlena D. , Kozhukhovskaya Veronika V. , Sokolova Olga V.
Published: February 2025

Bovine clostridiosis is one of the major problems in veterinary medicine, animal husbandry and food safety. Clostridia cause zoonotic infectious diseases. The causative agents of clostridiosis produce highly resistant spores that can persist in the environment for a long period of time. They are also present in the gastrointestinal tract and as spores in the tissues of healthy animals and can cause disease due to temperature or productive stress, mineral imbalances, injury and impaired immune response.
The aim of our work was to develop new and optimize existing PCR protocols for the diagnosis of Clostridium bacteria and Cl. perfringens toxinotypes. The relevance of the development of PCR kits is associated with the lack of commercially available ones for the diagnosis of many types of clostridia. This makes it difficult to make the correct diagnosis and select rational therapy and vaccination.
Materials and methods. Developed and optimized methods for the diagnosis of clostridiosis are based on real-time PCR and conventional PCR.
This article presents the results of the development of PCR methods for rapid and inexpensive diagnosis of clostridial infections that are significant for livestock farming. For the first time, PCR kits were created for the detection of Cl. sordellii, Cl. novyi (types A, B) using conventional PCR and Cl. histolyticum in real time. Moreover, we have optimized PCR conditions and reagent mix for the detection of Cl. chauvoei, Cl. septicum in real time, Cl. tetani, Cl. botulinum using conventional PCR as well as a multiplex PCR for Cl. perfringens (A-E) typing.
Building Educational Programs for Additional Professional Education Based on a Client-Oriented Approach
Authors: Sharonov M. , Kozhuhov S. , Sharonova O.
Published: February 2025

Today, the educational services market is undergoing major changes, and this fully applies to both higher or secondary vocational education programs and additional vocational education programs. The nature of this lies primarily in the active introduction of professional standards into the real sector of the economy. Increasingly, starting from the 4th level of qualification, they require the performance of a sufficiently large and wide range of work functions that were not previously included in the range of professional tasks of these employees. For example, according to the professional standard 31.004 \"Specialist in maintenance and repair of mechatronic systems of motor vehicles and their components in the automotive industry\" approved by the order of the Ministry of Labor and Social Protection of the Russian Federation dated 04/02/2024 No.170n, which entered into force on September 1, 2024 and is valid until September 1, 2030 a generalized labor function was added to the functionality of purely technical personnel: \"Interaction with consumers in the process of performing maintenance and repair of vehicles and their components in the automotive industry\"
In this regard, the article attempts to identify generalized approaches to the process of building customer-oriented educational programs and trace the dynamics of their demand in the educational services market. After all, today it is necessary to understand that the competitiveness of such specific products largely depends on the ability to meet the target needs of the student, in terms of achieving a specific and understandable result for him. Indeed, in the example given, an employee is required to have an absolutely specific ability, if necessary, to competently build and implement the process of interaction with the client, perhaps even in an extremely difficult, one might say, stressful situation.
Improving the Professional Competence of Teachers in the Context of Inclusive Education
Authors: Panasenkova M. , Mikulan I.
Published: February 2025

Currently, the problem of professional competence of teachers involved in working with students with limited health opportunities in inclusive education is quite important. For most teachers, working with such children is a serious problem. This is due to a lack of knowledge and skills in the organization of correctional work with children, the development of an adapted educational program. The article considers different interpretations of the concept of professional competence of a teacher, the main problems of teachers working with children with disabilities. The purpose of the study was to study the level of competence of teachers in the organization of work with students with disabilities. Present the results of the conducted research, as well as approaches to improving the professional competence of teachers.
Effectiveness of Sports-Based Interventions for Mental Health in At-Risk Youth: A Systematic Review
Authors: Rowińska Katarzyna , Siembab Karolina , Bednarczyk Daria , Białeta Julia , Napieralska Agnieszka , Černohorská Alicja , Garbarczyk Wiktor , Jurkiewicz Michalina , Kapla Albert , Pysiewicz Wiktoria
Published: February 2025

Adolescents’ mental health is a growing public health concern, particularly for at-risk youth exposed to adverse circumstances such as poverty, trauma, discrimination, or social exclusion. These individuals face higher risk of developing mental health issues, including anxiety, depression, and post-traumatic stress disorder (PTSD), which can significantly impact their education, social interactions, and long-term well-being. Addressing these challenges requires holistic, non-stigmatizing approaches, which will be tailored to the unique needs of at risk youth. Sports-based interventions have emerged as a promising strategy to promote mental health by leveraging the psychological and social benefits of physical activity. This systematic review analyses the effectiveness of sports-based interventions in improving mental health outcomes in at-risk youth, focusing on areas such as anxiety, depression, PTSD, self-esteem, social skills, and emotional regulation.
Becker Muscular Dystrophy and Nephrotic-Range Proteinuria: Chance or True Association?
Authors: Yang Qunlan , Liu Yan , Song Shaona , Wang Wenhong
Published: February 2025

Aims/Background Improved life expectancy has led to an increased recognition of kidney dysfunction as a common complication in adults with Duchenne muscular dystrophy (DMD). However, data on renal impairment with Becker muscular dystrophy (BMD) especially in pediatric populations, and remains scarce.

Case Presentation We present the case of a 5-year-old male with a two-month history of foamy urine. Laboratory investigations revealed nephrotic-range proteinuria and elevated serum creatine kinase (CK) levels. A subsequent muscle biopsy and genetic analysis confirmed the diagnosis of BMD.

Results The patient accepted oral deflazacort for two months. Surprisingly, this targeted treatment at BMD not only led to a reduction in CK levels, but also resolved proteinuria during the two-year follow-up.

Conclusion This clinical presentation of nephrotic-range proteinuria in pediatric BMD patients is novel and highlights a rare renal manifestation. Chronic kidney impairment in pediatric BMD warrants attention, and the role of kidney biopsy in characterizing DMD/BMD-associated nephropathy should be explored. Given the lifelong and heterogeneous nature of BMD, multicenter study and long-term follow-up are required to better understand the progression, underlying mechanisms, and clinical outcomes of renal complications in these patients.
Managing your Palliative Patient
Authors: Herodotou Nicholas
Published: February 2025

Palliative Care is the symptom management of any patient who has an irreversible, progressive, life-limiting condition and is not solely cancer patients. It aims to enhance quality of life, utilizing a holistic, multidisciplinary approach. Good symptom management of palliative patients is what every clinician should be able to deliver. This short article addresses the practical management of how to commence strong opioids, palliative surgical interventions, palliative emergencies and lastly, when do you stop treating a patient who is clinically deteriorating.
Efficacy of Triptorelin Combined with Recombinant Human Growth Hormone (rhGH) on Serum Sex Hormones, Bone Age, and Clinical Outcomes in Girls with Precocious Puberty
Authors: Lao Xiaofei , Zhao Lihong , Zhu Xiaoqiang , Yao Xinmei , Chen Huichao
Published: February 2025

Aims/Background Triptorelin effectively delays bone age progression in children with precocious puberty but may suppress pituitary growth hormone response, affecting growth hormone-binding protein secretion and overall growth rate. This study aimed to evaluate the efficacy and safety of triptorelin alone versus in combination with recombinant human growth hormone (rhGH) in treating girls with precocious puberty.

Methods This retrospective study examined 82 girls with precocious puberty treated at The First People’s Hospital of Tongxiang from January 2021 to June 2023. Patients treated with triptorelin alone were assigned to the control group (n = 42), while those treated with triptorelin combined with rhGH formed the study group (n = 40). Both groups received continuous treatment for one year. Outcomes, including efficacy and safety, were compared between the groups.

Results Following treatment, height and body mass in the study group were significantly higher than those in the control group (t = 2.126, p = 0.037; t = 2.419, p = 0.018). The bone age/chronological age (BA/CA) ratio in the study group was significantly lower than that in the control group (t = 2.185, p = 0.032). Levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in the study group were also significantly reduced compared to the control group (t = 2.208, p = 0.030; t = 4.492, p < 0.001; t = 2.952, p = 0.004). Furthermore, left and right ovarian volumes and uterine volume were significantly lower in the study group than those in the control group (t = 2.740, p = 0.008; t = 2.936, p = 0.004; t = 2.520, p = 0.014). After one year, the effective treatment rate in the study group was higher than that in the control group (97.50% vs 80.95%, p < 0.05). No serious adverse reactions were observed in either group during the treatment period.

Conclusion The combination of triptorelin and rhGH demonstrates a clear therapeutic in girls with precocious puberty, which effectively delays bone age growth, regulates sex hormone levels, and reduces ovarian and uterine volumes without severe adverse effects.
Before and after the Ikon
Authors: Vaneyan Stephan
Published: February 2025

Abstract: This paper takes a critical look at the ikonic type of image, the “sacred image” as the “face” of the Eastern Christian tradition and the way it identifies itself, both aesthetically and ideologically. Is the union of the two inevitable and inseparable? Does this union still work? How and when did the ikon become the only possible artistic form of sacred representation for the Eastern Christian tradition? Has the ikon, with its origins in a form of art for which any mimetic (figurative and objective) representation becomes merely one among its many motifs—that is, in decorative art—has the ikon ever been art in the proper sense? Or has it merely been a type of visual practice, which, at some point, acquired independence and mobility, as did easel painting? Furthermore, how did this purely “designer” visual practice, this maniera greca , shape the aesthetics and even the artistic ethics of the Christian East?
The Work of Art in Spiritual Experience
Authors: Coupar Regina
Published: February 2025

Abstract: Writing from the perspective of a practicing visual artist, and drawing from my original doctoral research (D.Min., University of Toronto, 2014), I will show that the creation and appreciation of visual art can provide a direct avenue for aesthetic experience relevant to religion. As my historical and contemporary examples suggest, in connection with the theoretical work of (among others) Mikel Dufrenne and William James, aesthetic experience can constitute religious experience in the context of a number of distinct Christian communities, though still challenged in this role by conventional practices and expectations.
The Limits and Liberty of Loyalty: Black Loyalism in the Book of Negroes
Authors: Tillman Kacy Dowd
Published: February 2025

Abstract: This article analyzes Black loyalism during the American Revolution as the Book of Negroes represents it. The Book is partly a ledger of names and partly a series of petitions written in 1783. People in this book's ledger were considered free and left New York to start a new life outside of America. I argue that this book should be read as mediated micronarratives and considered collectively as Black auto/biographies embedded within white-authored documents. I also argue that these micronarratives counter the dehumanization of the Book , which often uses the language of numeracy to objectify Black loyalists and threatens to undermine the I-statements of the petitions. When read this way, we can see the Book as an artifact of life writing; as a record of the codification (or attempted codification) of Black loyalty and loyalism; and as an example of white surveillance technology of Black lives. Implicit in these claims is that this Book is one of the earliest and largest collections of circumatlantic Black loyalist authorship, if we know how to read it.
Pockets Full of Ashes: The Lingering Embers of the Revolutionary War in the South
Authors: Grandjean Katherine
Published: February 2025

Abstract: The Revolution, in the South, was a ghastly civil war. For some, the scars did not fade quickly. Although recent historiography has emphasized the surprising amount of reconciliation among former enemies after the fighting ended, the postwar scene—when viewed through the perspectives of ordinary southerners—is more complicated. Looking broadly at the fates of loyalists, at stories that were told about living former loyalists, and at folk memory, this piece presents a more unsettled view of the Revolution's aftermath. Even after war's end, bad feelings lingered—much longer than we might imagine. The legislatures of the southern states may have moved toward reconciliation, but many men did not. Neither the stigma of loyalism nor the memory of the war's viciousness dissipated easily. Using early histories, memoirs, newspapers, letters, and local lore, this article gauges the troubled long-term memory of the Revolution, as it existed in the minds of those who lived through it.
When the Quaker Light Burns out Black Resistance Strategies for Unearthing a More Inclusive Community Story
Authors: Jordon Shamele
Published: February 2025

Abstract: Using diverse archival sources and oral history interviews, this essay examines how volunteer activist women in the 1970s galvanized support to pass major legislative reforms that made Pennsylvania a model for how to implement the federal Juvenile Justice and Delinquency Prevention Act (JJDPA) of 1974 at the state level. Horrified by conditions they witnessed on a tour of a nearby juvenile detention center, three Philadelphia area women created a broad-based coalition—centered in the Juvenile Justice Center (JJC) of Pennsylvania—to improve local conditions of confinement and spearhead novel policies to transform juvenile justice statewide. Focusing on Barbara Fruchter, JJC cofounder and de facto leader of the state’s deinstitutionalization campaign, this essay probes how a now well-accepted idea in juvenile justice—treating the great majority of delinquent youth in small community-based rather than large institutional programs—was first envisioned and introduced into American juvenile justice a half-century ago.
Polarization-multiplexing terahertz metasurface zone plate for implementing arbitrary spatial coordinate focusing
Authors: Tan Qi , Li Jie , Nan Tong , Zhao Zhengyi , Xu Hang , Li Hui , Zheng Chenglong , Zou Die , Xu Wenhui , Ding Guanchu , Chen Wenwei , Zhang Yan , Yao Jianquan
Published: February 2025

The design of metasurface structures based on the generalized Snell’s law enables diverse functionalities for regulating light fields through abrupt phase changes. However, addressing complex regulatory demands, such as polarization multiplexing, requires identifying multiple meta-atom structures that meet specific transmission and phase criteria. This process is often time-consuming and restrictive. Simplifying the design process for metasurface structures while preserving their functionality is, therefore, a key research area. In this paper, we demonstrate independent phase modulation of orthogonal linear polarization components by a simple structure integrating a Fresnel zone plate—a two-phase device—with a metasurface. We design and experimentally validate three metasurfaces: Sample M1 realizes concentric focusing at different focal lengths for x- and y-linearly polarized terahertz waves. Sample M2 enables off-axis dual-focus with orthogonal linear polarization multiplexing. Sample M3 employs a checkerboard distribution to achieve multi-focal focusing within a single channel. The simulation results are consistent with the experimental findings, confirming the feasibility of the proposed scheme and implementing arbitrary spatial coordinate focusing with dual channels. This work significantly simplifies the terahertz metasurface design process, reducing both complexity and time investment. It has the potential to promote the development of wavefront control devices towards miniaturization and multifunctionality.
The layering construction of the three-dimensional (3D) geological model for Wudalianchi volcanic area, Northeast China
Authors: Jiang Xue , Li Ranran
Published: February 2025

Establishment of geological model in volcanic area is challenging owing to lack of borehole data and the effect of volcanic activity on rock distribution. Taking full advantage of the existing complete volcanic landforms and recognized for seven eruptive cycles in Wudalianchi volcanic area, here we apply a layered approach to build geological models for meeting rapid development of agriculture and understanding the evolution of regional geological structure. Based on the volcanic eruption cycle, the stratas in Wudalianchi volcanic area are divided into four layers. UGrid (unstructured grid in GMS) is used combining with DEM data to hierarchically build 3D geological structure model of volcanic area, which realize the visualization of regional stratigraphic distribution, and the reliability of the model is verified by the formation mechanisms of different types springs. The stratified modeling provides a scientific and effective mean for the reconstruction of geological structure in volcanic areas where the data are short and the stratigraphic distribution is complex. The 3D geological structure model established can lay a foundation for the prediction, evaluation and sustainable use of regional groundwater, geothermy, mineral water and mineral mud resources.
Mechanisms of resistance against allylamine and azole antifungals in Trichophyton: A renewed call for innovative molecular diagnostics in susceptibility testing
Authors: Gupta Aditya K. , Wang Tong , Mann Avantika , Piguet Vincent , Chowdhary Anuradha , Bakotic Wayne L.
Published: February 2025

The emergence of antifungal resistance calls for continued research efforts to better guide healthcare providers in treatment selection and outcomes. Unlike bacterial infections, treatment of superficial fungal infections is mainly limited to allylamines (terbinafine) and azoles (itraconazole). Here, we aim to update our current understanding of resistance mechanisms against allylamine and azole antifungals in the Trichophyton genus. Resistance development has been demonstrated in vitro by challenging Trichophyton isolates with allylamines or azoles at levels below the minimum inhibitory concentration (MIC), which corroborates the observation of clinical resistance. Frequently reported mechanisms of resistance include: (I) Alterations of the drug target by single-nucleotide variations (SNVs) of the SQLE/ERG1 and ERG11 genes; in particular, SQLE SNVs (Leu393Phe, Leu393Ser, and Phe397Leu) have been frequently reported in isolates with high terbinafine MICs; (II) overexpression of the target enzyme for azoles (ERG11) and downstream genes in the ergosterol biosynthesis pathway can decrease the effective drug concentration as well as prevent the depletion of ergosterol and the accumulation of toxic sterol intermediates; (III) the up-regulation of drug efflux channels—belonging to the ABC superfamily (PDR1, MDR2, MDR3, MDR4), MFS superfamily (MFS1), or Pma1 (plasma membrane ATPase 1)—can reduce the effective concentrations of terbinafine and azoles. The possibility of multidrug resistance has been shown in Trichophyton strains, of both human and animal origins, harboring multiple resistance mechanisms (e.g., target alteration/overexpression and drug efflux channels). Tackling the issue of antifungal resistance will require an integrated approach with multidisciplinary efforts including surveillance initiatives and antifungal stewardship programs. However, these efforts are hampered by the current limited accessibility of antifungal susceptibility testing as well as the limited choice of antifungals available in routine practice. A better understanding of resistance mechanisms could help develop targeted, molecular-based assays.
Delirio y arbitrariedad: dos torres en Manhattan
Authors: Rodríguez García Javier , Trachana Angelique
Published: February 2025

Rem Koolhaas y Rafael Moneo son dos ejemplos de arquitectos que respaldan su práctica con teoría fundamentada en la investigación en torno al proyecto y la formatividad del objeto arquitectónico. Tomando como referencia el proyecto de la torre entre las calles 22 y 23 de OMA y los laboratorios de la Universidad de Columbia de Moneo, ambos para Manhattan, el objetivo es discernir los parámetros discursivos desde los que actúan ambos arquitectos y que plasman en sus escritos, mostrando métodos y campos de conocimiento desde los que desarrollan sus argumentos. La hipótesis que se demuestra es que el manhattanismo, la especulación teórica que desarrolla Koolhaas en Delirious New York (2004), proporciona referencias formales al proyecto, mientras que las claves teóricas que se desvelan en el proyecto de Moneo, se encuentran en sus textos Inquietud teórica y estrategia proyectual… (2004b) y Sobre la arbitrariedad en arquitectura (2005). Dichos escritos funcionan como subtextos de los proyectos. Del análisis en paralelo de los dos proyectos se concluye que el manhattanismo, teoría según la cual la arquitectura de los rascacielos de Manhattan se basa en parámetros pragmáticos y una envolvente de programas múltiples, se traduce en la torre de OMA en un programa icónico que, en su intento de ilustrar la teoría, entra incluso en contradicciones con esta. Por otro lado, el proyecto de Moneo resulta también una suerte de interpretación de parámetros pragmáticos de la situación encontrada y, sin embargo, se demuestra que la forma en absoluto carece de artisticidad y atributos que pertenecen al mundo subjetivo y fundamentos teóricos recurrentes del autor.
Motives and Determinants of Chinese Foreign Direct Investment in the CEE countries
Authors:   , Zhang Fumei
Published: February 2025

Traditional FDI theories are not sufficient to explain the OFDI activities from emerging markets. In the case of Chinese FDI, other factors such as the institutional, political and social factors are neglected in Dunning’s work will be added in the framework to analyze Chinese OFDI in the CEE countries based on the internationalization experience of Chinese MNCs. These factors are included in the institutional theory which will be revised or extended in the current research. From the perspectives of host countries, the location determinants cover various factors which are categorized into different levels and dimensions: macro-economic factors such as market size (domestic and regional market), labor cost and access to skilled labor, infrastructure, economic openness etc.. Besides, it is believed that intergovernmental linkage plays an important role especially in attracting Chinese investment in Hungary given that the investment growth comes along with the increasing political ties. Based on the literature review, the social and business network proposed in the international entrepreneurship network theories will be considered as well at the micro-level. Therefore, those potential social factors mentioned above are covered in the institutional theories.