bluuebunny/crossref_metadata_2025 huggingface dataset:
USING CLOUD TECHNOLOGIES TO OPTIMIZE THE EDUCATIONAL PROCESS AT SCHOOL
Authors: Kopeyev Zh. , Kabenov D. , Kusmanov K.
Published: December 2024

The article is devoted to the study of the use of cloud technologies in the educational process of schools, focusing on innovative approaches such as the «Flipped classroom» model. Cloud technologies provide ample opportunitiesfor students and teachers to work together, providing access to educational materials at anytime from anywhere, which contributes to the development of cognitiveindependence of students. The article discusses the types of cloud technologies, their advantages, including cost-effectiveness, accessibility and convenience, as well asdidactically the features of their use. Special attention is paid to the technology of mixed learning in the form of an «Flipped classroom «. Its advantages in comparisonwith the traditional approach are shown, including the activation of cognitive activity of students, increasing the level of their involvement, the development of critical thinking and cooperation skills. The experiment demonstrates the advantages of this technology in teaching computer science, including increasing the interest of schoolchildren in educational material and improving the quality of mastering the topic. The hypothesis of the study is that the use of cloud technologies in combination with the «Flipped classroom» model contributes to increasing the cognitive activity of students, developing their independence and improving the assimilation of educational material. The conclusions confirm the effectiveness of the proposed methodology, which is reflected in the increase in student engagement and quality indicators of their learning. It is concluded that the introduction of cloud technologies in school education contributes to the creation of a personalized and accessible educational process, stimulating the use of modern digital tools to improve the quality of education. The expediency of the adaptive application of the technology of the « Flipped classroom» in educational practice is substantiated.
DEVELOPMENT OF HYDROPONICS FOR THE FORMATION OF PRACTICAL SKILLS OF THE STEM EDUCATION SUBJECTS
Authors: Tlepbergenova A.E. , Yessenamanova M.S. , Yessenamanova Zh.S.
Published: December 2024

The article analyzes the use of a hydroponic device as a STEM education tool. STEM education is the basis of practical interest and a high level of motivation of schoolchildren for research activities and obtaining all the necessary competencies. The use of STEM technology will allow you to transfer the educational process to another basis: from observation to hypothesis and experiment, from studying individual subjects to studying phenomena, from obtaining abstract knowledge to solving real life problems. The hydroponic system as a teaching technology can be used in the study of a number of school subjects: computer science, biology, chemistry, physics and natural sciences. First of all, in order to build the design of a hydroponic installation, creative data is needed on the selection of necessary products, the ability to work with tools for connecting plastic pipes, connecting to a pump, etc. In the manufacture of the structure, it is necessary to calculate the length, height of the structure, the number of holes for pots, when connected to the pump, etc. In addition, it is necessary to calculate the amount of nutrients necessary for the growth of plants, which are controlled by changes in the acid-base environment and total salinity. The hydroponic plant can monitor the growth and development of vegetable and green crops and monitor the transport of nutrients. In all courses of such subjects as "Natural Science", "Biology", "Chemistry" and "Physics", students will have the opportunity to gain practical skills when working with hydroponic devices.
ACTUALIZATION OF VARIOUS CATEGORIES OF CULTURAL HERITAGE THROUGH THE CREATION OF TACTILE COPIES OF WORKS OF FINE ART
Authors:   Kemerovo State Institute of Culture and Art, Abramova P. V. , Kaminskaya O. V. ,   Kemerovo State Institute of Culture and Art
Published: December 2024

The article is devoted to the actual problem of adaptation of visual arts for people with visual impairment. The potential of a tactile copy in the field of actualization of various types of cultural heritage is revealed. It has been established that the creation of a tactile station, including a copy of a work of fine art, an outrigger element, as well as an aromatic composition,
contributes to the actualization of ethnic, military-historical, historical and everyday, material and intangible heritage. The methods and techniques by which the production of tactile copies is carried out are revealed, as well as the ways of their integration into various forms of cultural and educational activities are determined: excursions, master classes, interactive programs. Based on the analysis of the Laboratory's experience in adapting regional artistic heritage for people with visual analyzer impairment, the high potential of tactile stations in creating an inclusive environment and transmission of the culturally significant information was revealed.
Large Models Enabled Ubiquitous Wireless Sensing
Authors: Hu Shun
Published: December 2024

In the era of 5G communication, the knowledge of channel state information (CSI) is crucial for enhancing network performance. This paper explores the utilization of language models for spatial CSI prediction within MIMO-OFDM systems. We begin by outlining the significance of accurate CSI in enabling advanced functionalities such as adaptive modulation. We review existing methodologies for CSI estimation, emphasizing the shift from traditional to data-driven approaches. Then a novel framework for spatial CSI prediction using realistic environment information is proposed, and experimental results demonstrate the effectiveness. This research paves way for innovative strategies in managing wireless networks.
Social Dumping Issue: European Union Measures and Social Protection Rights of Workers in North African Countries
Authors: İneci Sevgi
Published: December 2024

This study emphasized that social dumping issue remains problematic on a global scale. The background of this problem is the globalization of the economy, liberalization of trade and capital movements. They increase labor mobility, but due to labor productivity differences, they cause social dumping in countries where labor laws are weak and unqualified labor is dense. Social dumping causes unfair competition between countries and is therefore a practice that should be abolished in accordance with the International Labor Organization (ILO) Conventions. Solving this problem on a global scale, will be possible if countries implement the seven basic conventions of the ILO. The study examines the issue from two perspectives. The first is the European Union’s problems with social dumping and the measures it has taken, and the second is the progress of North African countries in adopting ILO Conventions, given their role as southern Mediterranean trade partners of the Union within the context of developing countries. Temporary assignment, as an application of the right of free movement of persons included in fundamental laws of the Union, covers temporary mobility of workers from one member state to another. This mobility affects wages leading to injustices and increase social dumping cases, due to differences in labor laws and labor productivity among member states, The Union is developing efficient measures to combat against this problem. As For North African countries, as relatively labor-intensive trade partners of the Union, their social protection will improve with the increase in the share of qualified labor in trade and capital movement with the European Union and their compliance with the fundamental conventions of the ILO.
Survey of Association Between Indoor CO and CO2 Levels and Symptoms of Sick Building Syndrome Among Employees at Alang-Alang Lebar and Plaju Health Centers
Authors: Delviana  , Fitri Agita Diora , Mariana
Published: December 2024

Poor air quality and exceptionally high CO and CO2 pollutants can be contributing factors to Sick Building Syndrome (SBS). This study evaluated the relationship between individual factors and CO and CO2 levels with Sick Building Syndrome (SBS) symptoms in health center employees. 74 respondents work in the room of Alang-Alang Lebar and Plaju Health Center. Then, the respondents will fill out a questionnaire related to SBS symptoms. The rooms in the selected health centers will be measured for CO and CO2  levels. The results of filling out the questionnaire will be analyzed to determine whether SBS or not, and the results of measuring CO and CO2 levels will also be categorized as normal or not. Univariate and bivariate analyses related to individual employee factors, SBS symptoms, and CO and CO2. The results of 74 respondents showed that 36 respondents (48.6%) experienced SBS. The highest SBS symptoms were red, itchy, dry, or watery eyes (75%), and symptoms of dizziness or headache (71.4%). The highest CO level measurement result was seven ppm, the lowest was six ppm, while the highest CO2 level was 561 ppm, and the lowest was 498 ppm. These measurement results are still within the normal limits of the standards set. Bivariate test results showed that individual factors, CO and CO2, are not significantly related to SBS symptoms (p > 0.05).
The Effect of EGFR DNA Methylation on the Incident of Endometriosis
Authors: Nida'ul Haq Anisah , Ocktariyana Ocktariyana , Hafy Zen , Saleh Irsan
Published: December 2024

Endometriosis is a gynecological condition characterized by the development of endometrial tissue outside the uterus, often leading to pain and infertility. We explore the relationship between endometriosis and the effects of DNA methylation on the Epidermal Growth Factor Receptor (EGFR) gene. DNA methylation, an epigenetic mechanism, involves adding a methyl group to cytosine bases followed by guanine in CpG islands, thereby influencing gene expression through hypermethylation or hypomethylation. In endometriosis, methylation patterns on specific genes can lead to transcriptional changes, impacting inflammatory processes and hormonal functions, such as estrogen, that support the growth of ectopic tissue. Variations in the EGFR gene's DNA methylation are linked to elevated cellular activity and expression, which aids in the pathophysiology of endometriosis. These findings highlight the potential of DNA methylation as a therapeutic target in treating endometriosis, offering hope for improved patient outcomes.
A Review Article on Ethnomedicinal Uses, Photochemistry and Pharmacological Activities of Crinum Latifolium
Authors: Mimrot Kavita Kumari , Shrama Rakesh , Jangir Surbhi , Singh Divya
Published: December 2024

Crinum latifolium, a prominent species of the Amaryllidaceae family, holds significant medicinal value in traditional and modern therapeutic systems. Known for its diverse pharmacological activities, including anti-inflammatory, antitumor, antiviral, and immunomodulatory properties, this perennial herb is extensively utilized in ethnomedicine across Asia and beyond. Its phytochemical profile includes alkaloids such as lycorine, crinamine, and haemanthamine, alongside flavonoids, saponins, and terpenoids, which contribute to its therapeutic efficacy. Crinum latifolium has been particularlyrecognized for its potential in managing conditions like benign prostatic hyperplasia, inflammatory disorders, and cancer. This review provides a comprehensive overview of the botany, ethnomedicinal applications, phytochemical constituents,and pharmacological activities of Crinum latifolium. Key studies highlight its immunomodulatory, hepatoprotective, and antioxidant properties, while toxicity evaluations underscore the importance of dose standardization to mitigate cytotoxic risks. Moreover, recent advancements in pharmacognosy and analytical chemistry have identified novel bioactive compounds, enhancing its pharmacological relevance. This synthesis of traditional knowledge and scientific findings aimsto foster a deeper understanding of Crinum latifolium, emphasizing its potential as a sustainable resource for drug discoveryand development. Future research directions are also identified, focusing on advanced clinical studies, molecular mechanisms, and formulation optimization.
Keywords: Medicinal plant, Crinum latifolium, ethomedicinal uses, phytochemistry, pharmacology
The Emotional and Social Long-term Effects on Pre-service Teachers on the University of Guanajuato in Mexico
Authors: Gallardo Duran Diana Paola
Published: December 2024

The COVID-19 pandemic has significantly altered various facets of daily life, particularly impacting higher education. This study investigates the emotional and teaching long-term effects of the pandemic on pre-service English teachers at the University of Guanajuato. The sudden shift to online teaching and learning imposed numerous challenges, exacerbating stress and anxiety among students while affecting their pedagogical training. This research aims to provide a comprehensive understanding of these impacts by examining the experiences of pre-service teachers during the pandemic. By identifying effective strategies for supporting pre-service teachers in similar crises, this study contributes to the existing literature on teacher education in times of crisis. It offers valuable insights into improving teacher training programs to better prepare future educators for unexpected disruptions. The findings highlight the importance of resilience and adaptability in teacher education, emphasizing the need for robust support systems and innovative teaching practices. This research not only enriches academic knowledge but also provides practical recommendations for enhancing teacher preparation in the face of global challenges.
The Status of the Druze Woman in Modern Society: Tradition, Challenges, and Social Change in the 21st Century
Authors: Faiad Fatin
Published: December 2024

In the small Druze family, or rather, the biological Druze family, the father's image dominates while in the extended family, the status of the elder person is respected, and his home serves as a center for the entire extended family (Nabwani, 2005). The father of the family has great authority and control over his family members including expenses and income, choosing a spouse for his children, choosing a political affiliation, and other matters. As for the woman over the years, she has been imprisoned in her home, and a wall of stone and fence protects her yard. On her way through the narrow village alleys, she walked covering her head with a white scarf (Halabi, 1987). Traditional norms have restricted her place, her independence and her freedom of expression. However, over the years, this status has begun to weaken because the woman in the Druze society has experienced many changes in all areas of life, though slowly and partially. It is important to understand what the causes were, what the changes were affected by, and how this was expressed in the social and traditional religious framework. The questions that are frequently raised among the Druze community include: Where is the Druze woman going now? How much does the status of the Druze woman affect a variety of areas such as health, education and individual freedom?
Integrating Smart IoT and AI-Enhanced Systems for Predictive Diagnostics Disease in Healthcare
Authors: Suhag Pandya
Published: December 2024

A developing technology known as the IoT allows for the connectivity of seemingly innocuous gadgets to the web. The IoT has linked millions of sensors and smart devices, which has transformed the healthcare sector. IoT devices driven by AI can identify diabetes by continuously gathering accurate glucose values. This study addresses the critical need for early and accurate diabetes detection using advanced ML algorithms, leveraging the Pima Indian Diabetes Dataset. An accuracy of diagnosing diabetes and non-diabetic cases is evaluated and compared in this study using models such as CNN, XG-Boost, DT, and SVM. Show that the model may improve diagnostic accuracy and facilitate early intervention by conducting a thorough performance evaluation utilising confusion matrices and measures like recall, accuracy, precision, and F1-score. CNN demonstrates superior accuracy of 99% with high precision of 98% and recall rates of 99.9%, positioning it as the most effective model for diabetes detection in this study. The findings underscore the feasibility of DL approaches in healthcare data analysis, contributing to improved healthcare outcomes in diabetes diagnostics.
гічна та правова спадщина професора Петра Павловича Музиченка : зб. матеріалів круглого столу [Електронний ресурс]
Authors:   Національний університет «Одеська юридична академія»
Published: December 2024

До збірника матеріалів круглого столу «Науково-педагогічна та правова спадщина професора Петра Павловича Музиченка» увійшли результати історико-правових досліджень наукової та педагогічної діяльності професора Петра Павловича Музиченко, а також дотичних до його діяльності тем. Матеріали представлені в авторській редакції. Відповідальність за зміст матеріалів, точність наведених фактів, цитат, посилань на джерела, достовірність іншої інформації та за додержання норм авторського права несуть автори.
Machine Learning Solutions for Predicting Stock Trends in BRICS amid Global Economic Shifts and Decoding Market Dynamics
Authors: Nigar Sultana  , Shaharina Shoha  , Md Shah Ali Dolon  , Sarder Abdulla Al Shiam  , Rafi Muhammad Zakaria  , Abid Hasan Shimanto  , S M Shamsul Arefeen  , Abir Shake Ibna
Published: December 2024

In this paper we examine the role of machine learning (ML) in predicting stock market trends within BRICS economies. Complex, interdependent global and regional economic factors are today and will in the future increasingly influence stock markets, which necessitates innovative techniques for trend analysis. Using this state of the art ML models Support Vector Machines (SVMs), Random Forests, and neural networks the study predicts market fluctuations based on historical stock data, economic indicators and geopolitical events. This research emphasizes the increasing role of deep learning, especially with models such as Transformers and LSTMs, to meet the demand for high accuracy predictive systems in the volatile market. Its analysis brings model performance into comparison of BRICS nations, taking into account the peculiar financial and economic behavior peculiar to each of them. These results illuminate how ML can provide actionable intelligence for investors and policymakers to better manage risk and better make strategic investments. Findings from the study underscore the requirement for adopting sophisticated data driven tools in order to negotiate the intricacies of globalized financial systems. This study also explains the basis in helping us understand how machine learning changes the perspective on stock market analysis. It is a great source to understand how different ML techniques such as Support Vector Machines which are good at classification problems and Random Forests, which are known to handle over fitting, can be used on a financial dataset. It shows cutting edge tools for market prediction such as deep learning models like LSTMs, which are able to handle sequential time series data, or Transformers that further improve the traditional architectures with attention mechanisms. The paper also discusses data preprocessing methods, such as feature engineering and normalization, and the importance of their inclusion in improving model performance. This research shows the value of ML literacy and provides future financial analysts and decision makers with tools for addressing market volatility in a data driven and strategic context.
MODERN ASPECTS OF METHODOLOGICAL SUPPORT OF GEODETIC MONITORING OF OBJECTS AND TERRITORIES
Authors: Nesterenko S. , Radzinska Y. , Yevdokimov А. , Shterndok E.
Published: December 2024

This study is devoted to the analysis of modern methods and technologies of geodetic monitoring used to detect and control changes in geodynamic processes and structural deformations of infrastructure and natural systems. Geodetic monitoring is an integral part of infrastructure safety, environmental protection, and effective land management, as it allows assessing the stability of buildings, bridges, dams, mountain ranges, and other important structures, as well as natural landscapes. This study highlights the development and integration of innovative monitoring methods, such as GNSS, laser scanning, unmanned aerial vehicles, and other geodetic technologies.
The analysis of previous studies shows that the use of GNSS and laser scanning provides high accuracy and regularity of measurements, which is critical for real-time monitoring of infrastructure and for predicting possible deformations and displacements. The use of robotic total stations and automated networks reduces dependence on the human factor and speeds up data collection, ensuring a high level of measurement accuracy. At the same time, data processing using machine learning and artificial intelligence methods opens up opportunities for predicting possible changes in the stability of objects, which significantly increases the efficiency of geodetic monitoring.
The purpose of the study is to substantiate the need to use the latest technologies in geodetic monitoring to achieve high accuracy and timely detection of changes that may have critical safety implications. In particular, the use of GNSS in combination with automated total stations allows for continuous monitoring of large areas and detection of even minor changes in the structure of objects. The article discusses in detail the methods of camera processing of data obtained during laser scanning, which allows creating high-precision three-dimensional models for further analysis of changes.
It has been determined that the combination of GNSS, laser scanning and data analysis using machine learning technologies can achieve the reliability and accuracy required to monitor critical infrastructure facilities. Technological advances allow not only to detect current changes, but also to predict possible trends, ensuring timely response to risks and threats. The results of this study can be applied in the field of territory management, environmental protection, and the design of sustainable engineering solutions.
FUNCTIONS OF PROTECTION DEVICES IN THE FIRE SAFETY SYSTEM OF ELECTRICAL INSTALLATIONS
Authors: Shvedov V. , Rudyk Yu.
Published: December 2024

In this article, the goal of the research was achieved regarding the definition of regulatory requirements for fire safety of protection devices in 0.4 kV electrical wiring. This article describes the main functions of protection devices that affect the fire safety of electrical installations, identifies the possibilities of strengthening the functions of protection devices, and substantiates the approach to the formation of further research for the introduction of new functions of protection devices. The article describes the study of the development of automation of processes and the saturation of electronic and electrical equipment in industry and everyday life. Because of this, there is a high degree of increase in the risk of the emergency mode of operation of electrical conductors and the occurrence of burning and fire, which may lead to a rise in the number of accidents in the future. Analysis of Ukrainian and foreign publications shows that the direction of development of power supply systems is infrastructure: p2p market for households, electric car charging networks, demand response services, and the possibility of participation in frequency support in the network and operation in the virtual power plant mode.
This will lead to a further increase in requirements for reliability, safety, and protection of power supply, in particular, an increase in the functions of protection devices. The development of digitalization, security, and cloud technologies is marked by constant growth and innovation that are aimed at increasing the efficiency and reliability of the protection of electrical networks. This article also describes some modern trends in surge protection devices as a component of low-voltage network protection devices in the fire safety system of electrical installations. Devices for the protection of low-voltage networks play an important role in ensuring the fire safety of electrical installations. Correct selection, installation, and regular maintenance of these devices significantly reduce fire risks and contribute to the facility's overall safety. Due to the rapid development of the complexity of electrical consumers and requirements for their protection, it is necessary to conduct further research on the introduction of new functions of protection devices to increase their reliability, accuracy, and safety.
SIMULATION MODEL OF THE FUNCTIONING OF THE LOGISTICS SYSTEM FOR THE SUPPLY OF GRAIN CARGOES FROM UKRAINE TO THE COUNTRIES OF THE WORLD
Authors: Pavlenko O. , Volkova T. , Muzylov D. , Medvediev Ye.
Published: December 2024

The article analyses the existing developments in the logistics of grain and similar cargoes in international systems. Due to the increase in logistics costs, Ukrainian agricultural companies receive a lower price compared to world market prices - they have to bear the costs caused by an inefficient logistics system. Therefore, it is necessary to develop a simulation model of the logistics system for the supply of grain cargo from the producer to the seaport of departure, as the main hub of communication with ports around the world. And the modelling will allow us to determine the level of influence of the obtained data on the transport material flow on the efficiency of decision-making. It is proposed to build models based on Petri nets, which allow to study the behaviour of an object in real time by assessing the performance of the system without forecast data. Today, the logistics system of grain cargo delivery in Ukraine has a structure based on the interaction of participants: agricultural companies as producers and organisers of grain exports, farmers, transport and logistics companies, as well as the existing infrastructure of Ukrainian and foreign ports, railways, and roads. This principle of interaction allowed us to build a structural model of functional interaction in the grain supply system. Based on this interaction and the principles of organising the supply of grain cargoes from production (harvesting) to the port of departure, a two-tier model of the functioning of this logistics system was developed. At the top are models of data collection and processing by an agricultural company, and at the bottom is a simulation model of the logistics system. A simulation model of grain cargo movement from the sender to the seaport of departure based on Petri nets has been built, which reflects the structure of relationships between the elements of the system and the dynamics of changes in its states in a compact form. On the basis of the built model, a simulation was carried out for three variants of distribution of cargo flow by two modes of transport. It has been determined that the option of uniform distribution of grain cargo between road and rail transport allows to save time.
STAGES OF CREATING INFORMATION SYSTEMS FOR MANAGING THE ACTIVITIES OF HOTEL ENTERPRISES
Authors: Kolontaievskyi O. , Korniiets Ye.
Published: December 2024

The paper examines the impact of the war on the hospitality industry, which is facing an acute crisis. To overcome this challenge, businesses need a comprehensive transformation, including the introduction of innovations, improved service levels and the expansion of information campaigns, including in the digital environment. The post-war economic recovery is expected to be accompanied by a decline in wages and staff reductions, but the growing number of jobs will enable development in new areas such as automation and robotics. Automated management systems for the hotel business are becoming increasingly important as they help to reduce costs and increase productivity. In particular, the authors describe an algorithm for building enterprise management information systems (EMIS) that covers all stages from concept development to project support, emphasising the importance of security and flexibility in planning and implementing the system.
The algorithm for implementing an IMS begins with a conceptual study, which involves a survey of the facility, formulation of goals and objectives, analysis of documents and identification of software tools. After that, a technical assignment is developed that outlines the basic requirements for the future system. The design stage includes choosing a structural concept, defining database parameters, and creating a set of project documentation. Implementation includes the creation of software and the development of a user interface. The final stages include testing, putting the system into operation, and staff training. The final stage of system maintenance involves warranty service and adjustments to ensure the system's reliable operation in the long term.
Particular attention is paid to the creation of databases, which are the basis for the information system. Testing and experimental operation is the final step in the development process, ensuring the system's adaptation to real operating conditions. Implementation of an IMS at modern hotel enterprises allows achieving qualitative changes in management, contributing to safety, speed of operations, saving management resources and making timely management decisions.
The article also discusses the conditions necessary for the successful implementation of an IMS: choosing a reliable manufacturer, checking compatibility with local standards, professional qualifications of the team and financial feasibility. A systematic approach to the development and integration of information technologies in the management of hospitality enterprises ensures the effectiveness of solutions, improving their quality and productivity.
RADIOPHARMACEUTICALS BASED ON ANTAGONISTS OF CHEMOCINE RECEPTOR CXCR4 IN DIAGNOSTICS AND TREATMENT OF ONCOLOGICAL DISEASES
Authors:   Nonprofit Organization «National Cancer Institute of Ministry of Health of Ukraine», Dzhuzha D. O.
Published: December 2024

The review is devoted to the use of a new class of radiopharmaceuticals (RPs) – chemokine receptor ligands – in oncological practice. The chemokine receptor CXCR4 is of particular interest as a molecular target in the diagnosis and treatment of malignant tumors, as it plays an important role in carcinogenesis. By interacting with the chemokine CCXL12, it activates cell signaling pathways that affect tumor cell proliferation, angiogenesis, metastasis growth, and apoptosis inhibition. The CXCR4 receptor is overexpressed on the cell surfaces of many hematological malignancies and solid tumors; the expression is correlated with poor prognosis. Numerous inhibitors of the CXCR4/CXCL12 axis and their radionuclide-labeled analogues have been developed, which allow visualization of CXCR4 and radioligand therapy. The possibilities of using RP 68Ga-Pentixafor for the diagnosis of hemoblastosis and solid tumors are shown. The therapeutic RP 177Lu/90Y-Pentixather was tested in the complex treatment of spread hemoblastoses and showed the direct antitumor activity and the desired myeloablative effect. Taking into account the results already obtained and the importance of new therapeutic approaches, especially in the field of refractory spread malignancies, it is obvious that these studies will be further developed.
Key words: chemokine receptor CXCR4; 68Ga-Pentixafor; 177Lu/90Y-Pentixather; CXCR4-directed radionuclide diagnostics; radioligand therapy of hematological malignances.
N. Slyadneva’s bibliography theory: Challenges, risks, and opportunities
Authors: Lopatina N. V.
Published: December 2024

The author discusses the theoretical legacy of Russian bibliography scientist Natalia Andrianovna Slyadneva (1950–2023) through the lens of the contemporary bibliographic theory and practice. She attempts to reveal and promote among the scientific community the ideodocumentоgraphic approach developed by N. Slyadneva in her doctor’s thesis of 1994. The concepts of the ideodocumentographic approach and its value for the bibliographic science for that period are discussed; its theoretical and practical impact on the contemporary information environment is examined. Within the relevant conceptual framework of library and bibliographic sciences, the logics of theoretical construction and the theory key provisions are revealed: Slyadneva’s understanding of bibliography and bibliographic method, specific character of bibliographic object contemplation, hierarchy of sovereign information entities (meanings, text, document, author), and bibliographic information cycle. The author endeavors to explain why the theory has not been implemented in the professional practice and to identify the consequences of rejecting ideographic forms of bibliographic information. The article is based on the author’s private archive.
Соціально-психологічні особливості ефективної комунікації працівників сфери бізнесу
Authors: Бугайова Наталія , Карнаухова Наталія
Published: December 2024

Стаття зосереджена на важливості розвитку комунікативних навичок у сучасному бізнес-середовищі. Надано аналіз наукових підходів до розуміння процесу комунікації. Визначено поняття комунікації в організації як складного та багатогранного процесу. Розглянуто умови ефективної комунікації в бізнес-середовищі. Виокремлено основні складові комунікативної компетентності як складової комунікативного процесу. Зазначено принципи щодо удосконалення навичок комунікації до рівня компетентності. Визначено перешкоди та бар’єри, які перешкоджають побудові ефективної комунікації.
Ключові слова: комунікація, спілкування, вербальна комунікація, невербальна комунікація, бар’єри спілкування, активне слухання, комунікативна компетентність.
On a conjecture concerning the number of solutions to \(a^x+b^y=c^z\), II
Authors:   Institute of Mathematics, Lingnan Normal College, Zhanjiang 524048, Guangdong, China, Le Maohua , Scott Reese ,   Somerville, MA, USA, Styer Robert ,   Department of Mathematics, Villanova University, Villanova, PA, USA
Published: December 2024

Let \(a\), \(b\), \(c\) be distinct primes with \(a\lt b\). Let \(N(a,b,c)\) denote the number of positive integer solutions \((x,y,z)\) of the equation \(a^x + b^y = c^z\). In a previous paper [16] it was shown that if \((a,b,c)\) is a triple of distinct primes for which \(N(a,b,c)\gt 1\) and \((a,b,c)\) is not one of the six known such triples then \((a,b,c)\) must be one of three cases. In the present paper, we eliminate two of these cases (using the special properties of certain continued fractions for one of these cases, and using a result of Dirichlet on quartic residues for the other). Then we show that the single remaining case requires severe restrictions, including the following: \(a=2\), \(b \equiv 1 \bmod 48\), \(c \equiv 17 \mod 48\), \(b \gt 10^9\), \(c \gt 10^{18}\); at least one of the multiplicative orders \(u_c(b)\) or \(u_b(c)\) must be odd (where \(u_p(n)\) is the least integer \(t\) such that \(n^t \equiv 1 \bmod p\)); 2 must be an octic residue modulo \(c\) except for one specific case; \(2 \mid v_2(b-1) \le v_2(c-1)\) (where \(v_2(n)\) satisfies \(2^{v_2(n)} \parallel n\)); there must be exactly two solutions \((x_1, y_1, z_1)\) and \((x_2, y_2, z_2)\) with \(1 = z_1 \lt z_2\) and either \(x_1 \ge 28\) or \(x_2 \ge 88\). These results support a conjecture put forward in [28] and improve results in [16].
Experimental murine non-alcoholic steatohepatitis is associated with behavioural, cognitive, and peripheral neuronal dysfunction
Authors: Prikhodko V. A. , Orlyakhina D. A. , Petrova V. D. , Karev V. E. , Ivkin D. Yu. , Napalkova S. M. , Okovityi S. V.
Published: December 2024

Introduction. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), the leading causes of chronic liver disease worldwide, are associated with a wide range of psychoneurological complications and conditions. However, the causal relationship between liver and nervous system disease remains poorly understood, which warrants the development of clinically relevant and valid animal models thereof.

Aim. The objective of this work was to characterize the short- and long-term psychoneurological and peripheral neuronal deficits that complicate different stages of NAFLD/NASH in mice.

Materials and methods. 68 adult male C57Bl/6 mice were randomized into Control or NASH groups. NASH was induced over 3 (Experiment 1) or 6 (Experiment 2) mo using a combined model including a high-fat diet and low doses of carbon tetrachloride. Control group received standard chow, drinking water, and equivolume normal saline. Animal behaviour was assessed by the Open field (OF), Elevated plus maze (EPM), and Light/dark box (LDB) tests at 1, 2, 3, and 6 mo of NASH induction. Visuospatial memory was assessed by the Spontaneous alternation in the T-maze and Novel object recognition tests at 1, 2, and 3 mo of NASH modelling, and using the Barnes maze at 6 mo of NASH induction. Following 3 mo of NASH induction, needle electroneuromyography (ENMG) was performed on the gastrocnemius and biceps muscles with the electrical stimulation of the sciatic and musculocutaneous nerves, respectively. Liver pathology was confirmed by histomorphology. Statistical analysis was performed using Prism 10.2.3 and R 4.2.3 with RStudio 2024.09.0.

Results and discussion. Experimental modelling was associated with poorer overall survival (p < 0.05, p < 0.01) and substantial evidence of liver injury, i.e. cholestatic hepatitis, medio- and macrovesicular steatosis, focal necrosis and fibrosis of varying severity (p < 0.05, p < 0.01). Mice with NASH exhibited markers of elevated anxiety in the OF, EPM, and LDB tests (p < 0.05, p < 0.01), which were mostly specific to the very onset of liver disease (1 mo) as well as its later stages (6 mo). NASH was also associated with a significant decrease in spontaneous alternation at 3 mo (p < 0.01), negative object disrimination at 2 mo (p < 0.05), and poorer memory retention in the Barnes maze (p < 0.05, p < 0.01) compared with Control. ENMG data analysis revealed significantly lower peak M-wave amplitudes (p < 0.01) and threshold currents (p < 0.05) in the gastrocnemius, and increased peak latency in the biceps in the NASH group (p < 0.05).

Сonclusion. Experimental alimentary/toxic NASH in male C57Bl/6 mice is associated with increased anxiety-like behaviour, visuospatial memory acquisition and retention impairment, and evidence of axonal and demyelinating peripheral motor neuropathy.
Comparative efficacy study of experimental chronic heart failure
Authors: Ivkin D. Yu. , Zelentsova A. B. , Krasnova M. V. , Karpov A. A. , Pazheltsev V. V. , Napalkova S. M. , Terninko I. I. , Titovich I. A. , Okovitiy S. V.
Published: December 2024

Introduction. Combination therapy of chronic heart failure (CHF) is an urgent and important treatment strategy, as it allows to achieve an improvement in the prognosis, optimal control of the symptoms of the disease and an increase in the quality of life of patients.

Aim. Comparison of the effectiveness of the malonic acid derivative ethmaben, the sodium-glucose cotransporter inhibitor empagliflozin and their combinations with the variability of the starting drug in experimental post-infarction chronic heart failure in rats.

Materials and methods. In a model of post-infarction chronic heart failure, reproduced by permanent ligation of the left coronary artery in rats, an echocardiographic study was used to compare etmaben and empagliflozin monotherapy with a combined regimen of these drugs. The concentration of etmaben in the myocardium was assessed by HPLC.

Results and discussion. Antagonism between etmaben and empagliflozin was revealed, manifested by a decrease in the effect of combination therapy in relation to any of the components, a decrease in the concentration of malonic acid derivative in the myocardium under the action of a type 2 sodium-glucose cotransporter inhibitor was shown.

Conclusion. Based on the data obtained, additional studies of pharmacokinetics and pharmacodynamics of etmaben were planned.
Impacto del Acuerdo Comercial con China: ¿Un Impulso Económico para Ecuador o un Enfoque Meramente Extractivista?
Authors: Lozano-Rodríguez Karen , Moreta-Gallegos Alex , Coral-Guerrero Carmen
Published: December 2024

El acuerdo comercial entre Ecuador y China ha generado un amplio debate sobre sus impactos en la economía del país. Este artículo analiza la relación comercial entre ambas naciones, con un enfoque particular en las implicaciones que el acuerdo tiene para los sectores productivos ecuatorianos. Se exploran los beneficios potenciales para la economía de Ecuador, como el incremento de las exportaciones y la atracción de inversiones, así como los posibles riesgos asociados con la dependencia de recursos naturales. A lo largo de este análisis, se revisan los términos del acuerdo, sus efectos en el comercio bilateral y las oportunidades que podría ofrecer para diversificar la economía ecuatoriana, además de un análisis de los efectos de otros TLC con China en la región. Asimismo, se discute la posible consolidación de un modelo extractivista, en el cual el país se mantenga como proveedor de recursos naturales sin un desarrollo significativo de industrias de valor agregado. Este artículo busca, en última instancia, responder a la pregunta: ¿Cuál es el impacto del acuerdo comercial entre Ecuador y China en la economía ecuatoriana, y en qué medida este acuerdo fomenta un crecimiento económico sostenible en lugar de perpetuar un enfoque extractivista?.
El compliance y la cultura de cumplimiento como mecanismos para prevenir la corrupción
Authors: Alvear-Tobar Estefany
Published: December 2024

El compliance se refiere al cumplimiento de normas legales y éticas dentro de una organización, con el objetivo de prevenir infracciones, incluyendo sanciones internas. Fue originado en los EE. UU. en el siglo XX, se consolidó en el contexto empresarial tras escándalos de corrupción, con programas diseñados para asegurar que las empresas cumplieran con las leyes. Estos programas se dividen en áreas específicas, como el cumplimiento tributario o penal, y deben adaptarse a las necesidades particulares de cada empresa, evitando el "paper compliance", que son programas superficiales sin impacto real.Además de implementar programas, las empresas deben fomentar una cultura de cumplimiento, en la que todos los empleados adopten una mentalidad ética, priorizando el cumplimiento normativo por convicción. Esta cultura también favorece la reputación corporativa, contribuyendo a una imagen de empresa íntegra. En Ecuador, el Código Orgánico Integral Penal (COIP) ha integrado el cumplimiento como atenuante de responsabilidad penal para las personas jurídicas, con requisitos como identificación de riesgos y controles internos. La lucha contra la corrupción, especialmente en el sector privado, puede verse fortalecida mediante la implementación efectiva de estos programas, aunque su aplicación en el sector público presenta desafíos, como la falta de incentivos para adoptar esta práctica.
Benefícios fisiológicos e psicológicos da dança em crianças e adolescentes: Uma revisão integrativa
Authors: Silva Iago Santarém da , Lima Luis Henrique da Silva , Boaventura Alessandra Bárbara César de Freitas , Viana Joaquim Albuquerque
Published: December 2024

O presente estudo teve como objetivo examinar os benefícios fisiológicos e psicológicos da dança, bem como seus efeitos em crianças e adolescentes. Também analisamos os tipos de dança aplicados em disciplinas e as metodologias utilizadas, investigando a dança como modalidade diferenciada para promover maior atividade física. A pesquisa foi realizada com base em estudos publicados nas últimas duas décadas em bases renomadas, como PubMed, MEDLINE e Web of Science, considerando apenas artigos revisados por pares e em inglês. Os resultados indicaram que a dança é uma alternativa eficaz às formas tradicionais de atividade física, proporcionando benefícios tanto para a população saudável quanto para aqueles com comprometimentos clínicos. A adoção de programas baseados na dança exige seu reconhecimento como estratégia de promoção da saúde, além de suporte financeiro e político para sua implementação. As conclusões destacam a necessidade de mudanças integradas nas políticas públicas de saúde, incluindo o incentivo ao debate e a formulação de legislações específicas que incorporam a dança como modalidade complementar. Tais medidas ampliam seu impacto como ferramenta de promoção da saúde pública, demonstrando sua relevância para melhorar a qualidade de vida de diversas questões.
Correlação entre alimentação e características zootécnicas em novilhas Nelores em fase de recria no cerrado
Authors: Cipriano Luanda Ferreira , Luvison Nicole  Amoêdo , Barros Camille Moreira Bergamo , Medeiros Dreyd Rodrigues , Martins Carolina Aires , Saraiva Gabriela Victoria Araújo , Teixeira Barbara Fernandes Werneck , Ferreira Isabel Cristina
Published: December 2024

Objetivou-se analisar as variáveis: peso, escore de condição corporal (ECC) e altura da garupa de 39 novilhas Nelore, na fase de recria, no período chuvoso do cerrado. A alimentação foi com o pasto de Brachiaria brizantha e B. decumbens com livre acesso ao sal mineral. Através da correlação de Pearson para as variáveis, peso e ECC, em função da idade, verificou-se que as maiores magnitudes foram obtidas nas variáveis razão peso: altura e entre variáveis peso e escore de condição corporal, concluindo-se que essas variáveis estão fortemente correlacionadas. A magnitude de correlação foi moderada entre as variáveis: altura de garupa e peso e intermediária entre razão peso: altura e altura de garupa e ECC e altura de garupa. Os parâmetros de peso, crescimento e escore de condição corporal tiveram um comportamento quadrático e ascendente no período estudado. Os valores de peso e ECC foram menores do que os dados da literatura citada.
ANALISIS TEGANGAN STATIK STANDAR SAMPING SEPEDA MOTOR MATIC MENGGUNAKAN BAHAN STEEL ALLOY DENGAN SOFTWARE SOLIDWORK
Authors: Ratna Fajarwati Meditama  , Diama Rizky Septiawan  , Agus Dwi Putra  , Bisyri Nur Wahid
Published: December 2024

Penelitian ini membahas analisis tegangan statik pada standar samping sepeda motor matic dengan bahan Steel Alloy, menggunakan metode elemen hingga dan perangkat lunak SolidWorks. Sepeda motor merupakan alat transportasi yang banyak diminati, khususnya di daerah pedesaan di mana pengguna sering kali memodifikasi standar samping untuk menopang beban tambahan. Standar samping adalah komponen penting yang memungkinkan sepeda motor berdiri stabil saat diparkir. Namun, komponen ini sering kali mengalami kerusakan akibat beban yang melebihi kapasitas desain awalnya. Penelitian ini bertujuan untuk mengevaluasi kekuatan struktural dan faktor keamanan standar samping saat diberi beban 2240 N. Hasil simulasi menunjukkan bahwa tegangan maksimum yang terjadi berada di bawah batas kekuatan material Steel Alloy yang digunakan. Faktor keamanan yang diperoleh mendukung penggunaan material ini dalam aplikasi standar samping, dengan asumsi pemakaian sesuai dengan batas beban yang diizinkan. Penelitian ini diharapkan memberikan kontribusi bagi pengembangan desain standar samping sepeda motor yang lebih tahan beban, terutama untuk kebutuhan di lingkungan pedesaan.