bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Benzothiazoles Bearing 1,3,4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study
Authors: Ewes Wafaa A. , Tawfik Samar S. , Almatary Aya M. , Ahmad Bhat Mashooq , El-Shafey Hamed W. , Mohamed Ahmed A. B. , Haikal Abdullah , El-Magd Mohammed A. , Elgazar Abdullah A. , Balaha Marwa , Hamdi Abdelrahman
Published: July 2024

Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class of targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown synergistic effects on tumor progression. Seeking to develop dual BRAF/VEGFR-2 inhibitors, we synthesized 18 amino-benzothiazole derivatives with structural similarities to reported dual inhibitors. Four compounds—4a, 4f, 4l, and 4r—demonstrated remarkable cytotoxicity, with IC50 values ranging from 3.58 to 15.36 μM, against three cancer cell lines. Furthermore, these compounds showed IC50 values of 38.77–66.22 μM in the case of a normal cell line, which was significantly safer than the reference, sorafenib. Subsequent investigation revealed that compound 4f exhibited the capacity to inhibit the BRAF and VEGFR-2 enzymes, with IC50 values similar to sorafenib (0.071 and 0.194 μM, respectively). Moreover, compound 4f caused G2-M- and S-phase cycle arrest. Molecular modeling demonstrated binding patterns compatible with inhibition for both targets, where 4f exerted the critical interactions in the BRAF site and interacted in the VEGFR-2 site in a manner akin to sorafenib, demonstrating affinity similar to dabrafenib.
Organic Electro-Optic Materials with High Electro-Optic Coefficients and Strong Stability
Authors: Feng Shuhui , Wu Shuangke , Zhang Weijun , Liu Fenggang , Wang Jiahai
Published: July 2024

The preparation of high-performance electro-optical materials is one of the key factors determining the application of optoelectronic communication technology such as 5G communication, radar detection, terahertz, and electro-optic modulators. Organic electro-optic materials have the advantage of a high electro-optic coefficient (~1000 pm/V) and could allow the utilization of photonic devices for the chip-scale integration of electronics and photonics, as compared to inorganic electro-optic materials. However, the application of organic nonlinear optical materials to commercial electro-optic modulators and other fields is also facing technical bottlenecks. Obtaining an organic electro-optic chromophore with a large electro-optic coefficient (r33 value), thermal stability, and long-term stability is still a difficulty in the industry. This brief review summarizes recent great progress and the strategies to obtain high-performance OEO materials with a high electro-optic coefficient and/or strong long-term stability. The configuration of D-π-A structure, the types of materials, and the effects of molecular engineering on the electro-optical coefficient and glass transition temperature of chromophores were summarized in detail. The difficulties and future development trends in the practical application of organic electro-optic materials was also discussed.
The Opportunities of Cellulose for Triboelectric Nanogenerators: A Critical Review
Authors: Zhang Renyun
Published: July 2024

Engineering polymers stand out as the predominant dielectric materials in triboelectric nanogenerators (TENGs), primarily owing to their robust triboelectric effect and widespread availability. However, growing environmental concerns surrounding these polymers have prompted a notable shift towards exploring alternative eco-friendly materials, with cellulose materials emerging as compelling contenders over the past few years. Cellulose, derived from various sources and presented in diverse forms and structures, has found utility as triboelectric materials. In contrast to many engineering polymers known for their chemical stability, cellulose materials exhibit heightened chemical activities. This characteristic provides a unique opportunity to delve into fundamental questions in TENGs by manipulating the physical and chemical properties of cellulose materials. This concise critical review aims to thoroughly examine the applications of cellulose materials while shedding light on the opportunities presented by these versatile materials.
Resveratrol Propionate Ester Supplement Exerts Antihypertensive Effect in Juvenile Rats Exposed to an Adenine Diet via Gut Microbiota Modulation
Authors: Tain You-Lin , Chang Chi-I , Hou Chih-Yao , Chang-Chien Guo-Ping , Lin Shu-Fen , Hsu Chien-Ning
Published: July 2024

Resveratrol, acting as a prebiotic, and propionate, functioning as a postbiotic, hold promise for preventing hypertension in chronic kidney disease (CKD). Previously, we employed propionate to enhance the bioavailability of resveratrol through esterification, resulting in the production of a resveratrol propionate ester (RPE) mixture. In this study, we purified 3-O-propanoylresveratrol (RPE2) and 3,4′-di-O-propanoylresveratrol (RPE4) and investigated their protective effects in a juvenile rat adenine-induced CKD model. To this end, male Sprague Dawley rats aged three weeks (n = 40) were divided into five groups: control; CKD (rats fed adenine); CKRSV (CKD rats treated with 50 mg/L resveratrol); CDRPE2 (CKD rats treated with 25 mg/L RPE2); and CKRPE4 (CKD rats treated with 25 mg/L RPE 4). RPE2 and PRE4 similarly exhibited blood pressure-lowering effects comparable to those of resveratrol, along with increased nitric oxide (NO) availability. Furthermore, RPE2 and RPE4 positively influenced plasma short-chain fatty acid (SCFA) levels and induced distinct alterations in the gut microbial composition of adenine-fed juvenile rats. The supplementation of RPE2 and RPE4, by restoring NO, elevating SCFAs, and modulating the gut microbiota, holds potential for ameliorating CKD-induced hypertension.
Skin Carotenoid Levels Are Associated with Demographic Factors, Body Size, and Fruit and Vegetable Intake in the Japanese Population
Authors: Okada Emiko , Kurotani Kayo , Takimoto Hidemi
Published: July 2024

This study aimed to determine the association between demographic factors, body size, and fruit and vegetable intake in the general population, focusing on individuals with both low and high skin carotenoid levels. This cross-sectional study was conducted during the 14th National Convention on the Promotion of Food and Nutrition Education (2019) in Yamanashi, Japan (a rural area) and the Open House 2019 at the National Institute of Biomedical Innovation, Health, and Nutrition in Tokyo, Japan (an urban area). Skin carotenoid measurements were conducted, and the participants were asked to fill out a self-administered questionnaire. The study population consisted of 492 Japanese individuals aged ≥16 years. The odds ratios (ORs) for low skin carotenoid levels were elevated in males, those who were overweight, and those who almost never consumed or consumed only one vegetable dish/day. Conversely, the ORs were lower in those living in Yamanashi, aged 30–39 and ≥70 years, and those who consumed fruit ≥1 time/week. For high skin carotenoid levels, the ORs were higher among those aged ≥70 years, living in Yamanashi, and those who consumed fruit ≥1 time/day or ≥5 vegetable dishes/day. Demographic factors, body size, and habitual fruit and vegetable intake may serve as indicators of skin carotenoid levels.
Correction: Trinh et al. LMP1-EBV Gene Deletion Mutations and HLA Genotypes of Nasopharyngeal Cancer Patients in Vietnam. Pathophysiology 2023, 30, 1–12
Authors: Trinh Cua Thi Hong , Tran Dung Ngoc , Nguyen Linh Thi Thao , Tran Nghia Tin , Nguyen Minh Trinh Gia , Nguyen Vy Tran Phuong , Vu Nhung Thi Hong , Dang Khanh Duy , Van Vo Kha , Chau Hoa Chieu , Phan Phi Thi Phi , Phuong Mai Huynh Truc
Published: July 2024

The authors would like to make the following corrections to the paper published [...]
The Role of Different Types of Cannabinoids in Periodontal Disease: An Integrative Review
Authors: Monteiro Viana Jaiane Carmelia , da Silva Gomes Gabriela Ellen , Duarte Oliveira Francisca Jennifer , Marques de Araújo Lidya Nara , Teles Guilherme , Mourão Carlos Fernando , de Vasconcelos Gurgel Bruno César
Published: July 2024

This integrative review addresses the potential of the Endocannabinoid System (ES) and cannabinoids in the pathogenesis and treatment of periodontal disease (PD). Cannabinoid receptors are expressed in healthy and inflamed periodontal tissues, indicating a potential regulatory role for SEC in oral homeostasis. Healthy periodontal cells express more CB1 receptors, while inflamed sites show increased CB2 receptors. This suggests a dynamic involvement of the SEC in the inflammatory response associated with PD. Cannabinoids such as cannabidiol (CBD) and cannabinoid receptor agonists such as HU-308, anandamide (AEA), and methanamide (Meta-AEA) have demonstrated promising therapeutic potential in studies. CBD has been associated with the control of bone resorption, antibacterial activity, and increased production of gingival fibroblasts, indicating effects in mitigating the progression of PD. HU-308 demonstrated preventive effects against alveolar bone loss, and anti-inflammatory, osteoprotective, and pro-homeostatic properties in animal models of periodontitis. AEA and Meta-AEA have anti-inflammatory effects by reducing pro-inflammatory mediators such as IL-1, IL-6, and TNF-α. The activation of cannabinoid receptors attenuates inflammatory processes, inhibits alveolar bone loss, exerts antibacterial effects, and promotes tissue repair. However, clinical trials are especially needed to validate these results and explore the therapeutic potential of cannabinoids in the treatment of PD in humans.
Calcium-Associated Anions Play a Dual Role in Modulating Cadmium Uptake and Translocation in Wheat
Authors: Safari Sinegani Mahboobe , Manzoor Maria , Mühling Karl Hermann
Published: July 2024

Cadmium accumulation in wheat as a daily food, even in low concentrations, is a serious threat to human health. Previous studies have reported conflicting results on the impact of calcium treatments on cadmium uptake and translocation in plants due to the complex soil conditions. Our hydroponic study offers clearer insights into how specific calcium treatment parameters influence cadmium uptake and translocation in wheat. The hydroponic medium was contaminated by cadmium (CdCl2) and the following treatments were applied: CaCO3, CaSO4, CaCl2, CaCO3 + CaSO4, CaCO3 + CaCl2, and CaSO4 + CaCl2. After harvesting, the wheat was analyzed for Cd2+ uptake characteristics including translocation factor, bioconcentration factor, and uptake. Furthermore, physiological growth parameters and plant nutrients were also determined. Applying CaCO3 significantly decreased wheat Cd2+ concentration by about three times in CaCO3 and two times in CaCO3 + CaSO4 and CaCO3 + CaCl2 treatments than in Cd-control. This study clearly elucidates that pH and CO32− were crucial in reducing Cd2+ concentration in wheat. SO42−, Cl−, and Ca2+ showed no effect on Cd2+ concentration. Ca2+ only reduced the translocation factor (TF) of Cd2+ in plants. CaCO3 also declined cadmium interference in the Mg2+, Mn2+, and Cu2+ uptake. Therefore, this study provides novel insight into the pure effects of calcium treatments on controlling cadmium contamination in plants, independent of soil effect.
Biomass Valorization through Catalytic Pyrolysis Using Metal-Impregnated Natural Zeolites: From Waste to Resources
Authors: Venegas-Vásconez Diego , Orejuela-Escobar Lourdes , Valarezo-Garcés Alfredo , Guerrero Víctor H. , Tipanluisa-Sarchi Luis , Alejandro-Martín Serguei
Published: July 2024

Catalytic biomass pyrolysis is one of the most promising routes for obtaining bio-sustainable products that replace petroleum derivatives. This study evaluates the production of aromatic compounds (benzene, toluene, and xylene (BTX)) from the catalytic pyrolysis of lignocellulosic biomass (Pinus radiata (PR) and Eucalyptus globulus (EG)). Chilean natural zeolite (NZ) was used as a catalyst for pyrolysis reactions, which was modified by double ion exchange (H2NZ) and transition metals impregnation (Cu5H2NZ and Ni5H2NZ). The catalysts were characterized by nitrogen adsorption, X-ray diffraction (XRD), ammonium programmed desorption (TPD-NH3), and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS). Analytical pyrolysis coupled with gas chromatography/mass spectrometry (Py-GC/MS) allowed us to study the influence of natural and modified zeolite catalysts on BTX production. XRD analysis confirmed the presence of metal oxides (CuO and NiO) in the zeolite framework, and SEM-EDS confirmed successful metal impregnation (6.20% for Cu5H2NZ and 6.97% for Ni5H2NZ). Py-GC/MS revealed a reduction in oxygenated compounds such as esters, ketones, and phenols, along with an increase in aromatic compounds in PR from 2.92% w/w (without catalyst) to 20.89% w/w with Ni5H2NZ at a biomass/catalyst ratio of 1/5, and in EG from 2.69% w/w (without catalyst) to 30.53% w/w with Ni5H2NZ at a biomass/catalyst ratio of 1/2.5. These increases can be attributed to acidic sites within the catalyst pores or on their surface, facilitating deoxygenation reactions such as dehydration, decarboxylation, decarbonylation, aldol condensation, and aromatization. Overall, this study demonstrated that the catalytic biomass pyrolysis process using Chilean natural zeolite modified with double ion exchange and impregnated with transition metals (Cu and Ni) could be highly advantageous for achieving significant conversion of oxygenated compounds into hydrocarbons and, consequently, improving the quality of the condensed pyrolysis vapors.
Refining Spatial and Temporal XCO2 Characteristics Observed by Orbiting Carbon Observatory-2 and Orbiting Carbon Observatory-3 Using Sentinel-5P Tropospheric Monitoring Instrument NO2 Observations in China
Authors: Guo Kaiyuan , Lei Liping , Sheng Mengya , Ji Zhanghui , Song Hao
Published: July 2024

The spatial and temporal variations in the atmospheric CO2 concentrations evidently respond to anthropogenic CO2 emission activities. NO2, a pollutant gas emitted from fossil fuel combustion, comes from the same emission sources as CO2. Exploiting the simultaneous emissions characteristics of NO2 and CO2, we proposed an XCO2 prediction approach to reconstruct XCO2 data based on the data-driven machine learning algorithm using multiple predictors, including satellite observation of atmospheric NO2, to resolve the issue of data gaps in satellite observation of XCO2. The prediction model showed good predictive performance in revealing CO2 concentrations in space and time, with a total deviation of 0.17 ± 1.17 ppm in the cross-validation and 1.03 ± 1.15 ppm compared to ground-based XCO2 measurements. As a result, the introduction of NO2 obtained better improvements in the CO2 concentration responding to the anthropogenic emissions in space. The reconstructed XCO2 data not only filled the gaps but also enhanced the signals of anthropogenic CO2 emissions by using NO2 data, as NO2 strongly responds to anthropogenic CO2 emissions (R2 = 0.92). Moreover, the predicted XCO2 data preferred to correct the abnormally low XCO2 retrievals at satellite observing footprints, where the XCO2_uncertainity field in the OCO-2 and OCO-3 products indicated a larger uncertainty in the inversion algorithm.
Towards The Development of a Governance System for Central Purchasing Body Collaboration and Performance
Authors: van de Goorberg Douwe J. P. , Stuijts Marcel A. J. , Thomas Andrew J.
Published: July 2024

This article explores the relationship between local authorities (mainly municipal organisations) and a central purchasing body (CPB). It critiques, from an agency theory perspective, the difficulties in aligning socio-economic goals of multiple municipal organisations with the pursuit of procurement goals by the CPB. The aim of this study is to explore which solutions, (governance mechanisms) for agency problems within a Dutch municipality–CPB relationship, are critical in aligning socio-economic goals within a collaborative public procurement (CPP) setting. The quantitative analysis of data from a questionnaire was used to conduct an explorative factor analysis (EFA). The questionnaire was issued to all municipalities in the Netherlands. Grounded on the EFA, the underlying factors within five categories of governance mechanisms for agency problems were recognised. Besides supporting the existing theory, this study provides additional knowledge in the field of agency theory and collaborative public procurement (CPP). The study resulted in the development of a comprehensive measurement scale to conduct research based on agency theory within the context of CPP governance and specifically in the area of central purchasing bodies. The results of this study are applicable in practise on an administrative and management level. Municipal organisations that initiate and/or govern a central purchasing body can take the results of this study into account to develop new standards on the further development of the CPB. At a managerial level, this study provides useful insight for decision-makers in municipal organisations to improve the way in which a CPB executes collective tenders at hand and determine if the joint approach delivers the best results in terms of their procurement objectives.
The Impact and Mechanism behind the Effect of a Digital Economy on Industrial Carbon Emission Reduction
Authors: Zhou Gang , Gao Jiaxin , Xu Yao , Zhang Yi , Kong Hao
Published: July 2024

Digital technologies hold significant potential for addressing environmental issues, such as air pollution and rising global temperatures. China is focusing on accelerating the dual transformation of industrial greening and digitization to accomplish the UN’s 2030 Agenda for Sustainable Development and sustainable economic growth. By combining a two-way fixed effect model, a mediated effect model, and a panel threshold model, this research endeavors to explore the effect that the expansion of the digital economy has on the level of carbon emission intensity that is produced by industry. The research yielded the following primary conclusions. (1) The digital economy effectively reduces the industrial carbon intensity via three distinct mechanisms: enhancements to the technological and innovative capacities of China, improvements in energy efficiency, and enhancements to the country’s overall industrial structure. (2) Regions where industrialization and digitization are highly integrated and developing, as well as the early pilot regions of the Comprehensive Big Data Pilot Zones, are particularly susceptible to this inhibitory effect. This research offers a theoretical backing for advancements in the digital economy; the achievement of energy-saving and carbon-reducing sustainable development objectives; and the establishment of green, ecologically friendly, and recycling development strategies.
Underwater Dam Crack Image Classification Algorithm Based on Improved VanillaNet
Authors: Zhu Sisi , Li Xinyu , Wan Gang , Wang Hanren , Shao Shen , Shi Pengfei
Published: July 2024

In the task of classifying images of cracks in underwater dams, symmetry serves as a crucial geometric feature that aids in distinguishing cracks from other structural elements. Nevertheless, the asymmetry in the distribution of positive and negative samples within the underwater dam crack image dataset results in a long-tail problem. This asymmetry, coupled with the subtle nature of crack features, leads to inadequate feature extraction by existing convolutional neural networks, thereby reducing classification accuracy. To address these issues, this paper improves VanillaNet. First, the Seesaw Loss loss function is introduced to tackle the long-tail problem in classifying underwater dam crack images, enhancing the model’s ability to recognize tail categories. Second, the Adaptive Frequency Filtering Token Mixer (AFF Token Mixer) is implemented to improve the model’s capability to capture crack image features and enhance classification accuracy. Finally, label smoothing is applied to prevent overfitting to the training data and improve the model’s generalization performance. The experimental results demonstrate that the proposed improvements significantly enhance the model’s classification accuracy for underwater dam crack images. The optimized algorithm achieves superior average accuracy in classifying underwater dam crack images, showing improvements of 1.29% and 0.64% over the relatively more accurate models ConvNeXtV2 and RepVGG, respectively. Compared to VanillaNet, the proposed algorithm increases average accuracy by 2.66%. The improved model also achieves higher accuracy compared to the pre-improved model and other mainstream networks.
Liking of and Willingness to Coexist with Animals among Residents near Nature-Based Destinations
Authors: Ng Yin Hui , Numata Shinya
Published: July 2024

The support of local stakeholders is crucial for the sustainable tourism management of nature-based destinations (NBDs). Local people near NBDs may have more interaction with wildlife; however, research on local people’s attitudes towards wildlife is surprisingly limited. To explore their liking and willingness to coexist with different wild animals, and the associated influencing factors, we conducted a survey of residents living near Tanjung Piai National Park (TPNP), Johor, Malaysia. Most of the residents had experienced numerous direct encounters with bats and snakes inside TPNP, as well as with wild boar and macaque monkeys outside of the park. The local people showed a high level of liking for animals but a relatively low level of willingness to coexist with them. The results of the statistical models suggest that the liking of animals is significantly influenced by childhood nature experiences and sociodemographic characteristics including sex, education, and the presence of children. Education was an effective factor shaping the preferences of favorable, fairly favorable, and unfavorable animal groups. On the other hand, willingness to coexist with animals was significantly influenced by childhood nature experiences, age, and sex. Age was an effective factor shaping willingness to coexist with favorable, fairly favorable, and unfavorable animal groups; specifically, elderly people showed a low level of willingness to coexist with animals compared to young people. Therefore, we conclude that in addition to providing educational programs for shaping preferences regarding wildlife, careful support and considerable efforts aimed at elderly people are essential to increasing residents’ willingness to coexist with animals to obtain wider support for NBD management.
SARS-CoV-2 Variants and COVID-19 in Bangladesh—Lessons Learned
Authors: Lytton Simon D. , Ghosh Asish Kumar
Published: July 2024

The coronavirus infectious disease-2019 (COVID-19) in Bangladesh is a paradigm for how one of the most densely populated countries in the world, with 1270 people per square kilometer, managed to cope with the COVID-19 pandemic under extraordinary circumstances. This review highlights the SARS-CoV-2 variants in Bangladesh and the timeline of their detection in the context of the global experience with the management of vaccination and natural SARS-CoV-2 infection. The motivation to overcome the COVID-19 vaccine dilemma and track Bangladeshi SARS-CoV-2 sub-variants underscores the potential for a low-income country to excel in international medical science, despite having stressed health care services and limited availability of resources for SARS-CoV-2 testing and gene sequencing.
Development of a CRISPR/SHERLOCK-Based Method for Rapid and Sensitive Detection of Selected Pospiviroids
Authors: Zhai Ying , Gnanasekaran Prabu , Pappu Hanu R.
Published: July 2024

Pospiviroids infect a wide range of plant species, and many pospiviroids can be transmitted to potato and tomato. Pospiviroids continue to be a major production constraint as well as of quarantine concern for the movement of germplasm, and are regulated in several countries/regions. The USDA APHIS issued a federal order requiring all imported tomato and pepper seeds be certified free of six pospiviroids of quarantine significance. The six pospiviroids of quarantine interest include CLVd, PCFVd, PSTVd, TASVd, TCDVd, TPMVd. Currently, those six viroids are detected by real-time RT-PCR. CRISPR/Cas-based genome editing has been increasingly used for virus detection in the past five years. We used a rapid Cas13-based Specific High-sensitivity Enzymatic Reporter unLOCKing (SHERLOCK) platform for pospiviroid detection, determined the limits of detection and specificity of CRISPR-Cas13a assays. This platform combines recombinase polymerase amplification (RPA) with CRISPR and CRISPR-associated (CRISPR-Cas) RNA-guided endoribonuclease that is rapid and does not require expensive equipment, and can be adapted for on-site detection.
Bioremediation of Cd-Contaminated Soil around Bauxite with Stimulants and Microorganisms
Authors: Feng Luxuan , Chen Xiaofeng , Yao Jinghua , Xiao Lei , Feng Xiujuan , Wu Shengmin
Published: July 2024

Heavy metal pollution in the soil around bauxite mines, especially cadmium pollution, is becoming more and more severe due to this mining becoming more frequent. Therefore, it is urgent to develop green and safe remediation technology. Biostimulants have been studied extensively, but their practical application is still challenging. In this study, the effects of humic acid (HA), glucose (GLU), and tetrasodium glutamate diacetate (GLDA), as well as their synergistic complex bacterial flora, on Cd-contaminated soil were analyzed. It has been shown that applying these three types of stimulants, individually or with complex bacterial flora, can enhance soil environment and quality. Nevertheless, the remediation efficacy of stimulants in combination with microbial communities surpasses that achieved through the use of stimulants alone. Among them, 1%GLU combined with complex bacterial flora had the best passivation effect on Cd, reducing the available Cd by 25%, followed by 0.5% GLU combined with complex bacterial flora and 0.5%HA combined with complex bacterial flora, which reduced the available Cd by 21.92% and 19.17%, respectively. The synergistic remediation method using stimulants and microorganisms can reduce the harm caused to the environment by conventional remediation methods and improve the effectiveness of soil remediation. It has broad application prospects in the field of bauxite-contaminated soil remediation.
SCALES OF FACTOR FOR COW LONGEVITY INDICES’ DETERMINATION
Authors: ПОПОВ Н.А.
Published: July 2024

В связи с внедрением интенсивных технологий производства молока и высоким уровнем кровности по голштинской породе в черно-пестрой и красно-пестрой породах сокращаются сроки производственного использования коров. Нами разработан и апробируется индекс продуктивного долголетия (ИД) с целью племенной характеристики животных красно-пестрой породы. Он рассчитывается по комплексу факторов. Показатели для расчета ИД оптимизированы по классам и представлены в 14 шкалах с учетом наследования и корректировки доступных для анализа данных на коров по живой массе, экстерьеру, типу конституции и др. Приведены факты апробации ИД, его применимости для коров селекционных групп, в том числе дифференцированных по линиям, породности по улучшающей голштинской породе красно-пестрой масти (КПГ). В качестве контрольной группы использованы высокопродуктивные особи симментальской породы с кровностью от 0 до 50%. Установлены повышенная МДЖ (на 0,095%; P<0,01) и превосходство по ИД (на 0,09 ед.) у коров линии М. Чифтейна 095679 по сравнению с теми же показателями животных других линий. Особи красно-пестрой породы с увеличенной кровностью по КПГ (свыше 63%) имели тенденцию к снижению ИД. Предложено осуществлять мониторинг лучших коров по ИД в стадах для племенной характеристики быков-производителей, используемых в популяциях красно-пестрой породы.

Due to the Holstein breed’s intensive milk production’s technologies introductiom and a high level of blood supply, there in black-and-white and red-and-white breeds, cows productivity terms using are shortened. We have developed and tested the productive longevity index (ID) for the purpose of red-and-white animals’ breeding characteristics’ study. It is calculated based on a set of factors. The ID indicators calculating by class and presented in 14 scales taking into account cows’ live weight, exterior, constitution type, etc. for inheritance and adjustments’ available data analyses are optimized. The ID facts’ testing, as well as its applicability to cows’ breeding groups including those differentiated by lines, pedigree according to Holstein red-and-white breed (KPG) improving are presented. The high production Simmental breed’s individuals with blood density from 0 till 50% as a control group were used. The increased MDJ (in 0.095%; P<0.01) and ID superiority (in 0.09 units) in the M. Chieftain 095679 line’s cows in compared to the same animals of the other lines’ indicators were found. The individuals of the red-and-white breed with increased KPG blood density (over 63%) to ID decreasing were tended. It is proposed the best ID cows in herds for the bulls breeding characteristics in red-and-white breed’s populations monitoring used.
ANALYSIS OF ONLINE ADVERTISING AND PRODUCT DISCOUNTS ON SALES VOLUME OF BREASTFEEDING CLOTHES PRODUCTS IN ONLINE STORES
Authors: Arvi Reza Nur , Pamuji Geraldi Catur
Published: July 2024

The aim of this research is to see the effect of online advertising and product discounts on the sales volume of breastfeeding clothing products in online stores via the Shopee application. The research uses quantitative method where observation was done through a total of 45 companies registered in the Shopee as a sample of data with a sales period of breastfeeding clothes from 2015 to 2022. The collected data was then plotted through a graph and analyzed to see the correlation using statistical method. The results of the research show that although the number of companies selling breastfeeding clothes continues to increase every year (X), sales of breastfeeding clothes also continue to increase every year (Y), this shows that the influence of online advertising and product discounts has a positive impact on the sales volume of breastfeeding clothing products
CHARACTERIZATION OF THE MAIN CHARACTER IN THE MOVIE ORION AND THE DARK (2024)
Authors: Pamungkas Rifky Iqbal Kukuh , Prihandini Asih
Published: July 2024

Character is an important element in storyline and conveys messages about social life in a narrative. The purpose of this study is to analyze the characterization of the main character Orion in the movie Orion and The Dark (2024). This study uses the theory of intrinsic approach by Edgar V. Roberts. Roberts. The method used in this research is descriptive qualitative method. The data used in this study are conversations between the main character and other characters from the movie Orion and The Dark (2024), which are available on the Netflix streaming platform. The object of this research is character of the main character named Orion. This analysis shows that Orion has timid, care, and faithful characters. Through this research, people can understand the importance of characters in a story in movies and other literary works. The conclusion of this study is the character of Orion in the movie Orion and The Dark (2024) has characterizations including care, faithful, helpful, timid, and judgmental. The impact of this research can provide knowledge of the importance of characterization in a story for the community
Advertisement Strategy using Semiotics as Marketing Approach: An Analysis on Food Product
Authors: Soegoto E S , Albar C N , Aisyah M , Luckyardi S
Published: July 2024

The aim of this study is to analyze and discover the effective advertisement strategy using semiotics approach and marketing review. This study used mixed method, which is the combination of quantitative and qualitative method. Questionnaire was used as the data collection method and supported by literature review. The questionnaire was distributed to 100 respondents in Bandung. The questionnaire regarding food advertisement was distributed to students as the study case. The results of this study showed that semiotics could maximize elements of an advertisement and have great effect in conveying the message which makes more potential consumers recognize and attracted to the product. This study concludes that food advertisements can attract more potential consumers if they focus more on the visual element. This study is expected to help food sellers in gaining more potential consumers which indirectly could increase the acquired income.
Visual Rhetorical Studies Documentary It Might Get Loud
Authors: Tarmawan Irwan , Priamanggala Muhammad Fariz
Published: July 2024

This study aims to prove that there is continuity between visual rhetoric theory and the three characters who convey messages to worthy khals through actions that have symbolic meaning. Film as an audio-visual language to feel joy, sadness, enthusiasm, and other emotions and feelings when the audience watches the film. Every film has a message to interpret and interpret something, even with the emergence of the documentary film genre which can factually inform a condition in the past. The film It Might Get Loud by Davis Gugenheim in 2008 with the documentary film genre rhetorically provides information about the development of music and musical genres from time to time. And in visual rhetoric theory there is a visual rhetorical perspective to understand the visual arguments of the three figures and in the end symbols can appear to produce meaning in the Documentary Film It Might Get Loud.
Marketing Politics of Government to Encourage Participation in Television Digitisation Programs
Authors: Desayu Surya Eka , Mamat Hkikmat Mahi
Published: July 2024

This study aims to photograph the political policies of the Government of Indonesia in peddling the Migration Program of Analog Television Broadcasts to Digital Television Broadcasts, so that a political marketing model is found. This program faces tough challenges, among others, the uneven understanding of society due to the wide area and the large number of television viewers. The government as a political superstructure actor must comprehensively communicate politics to encourage public participation in television digitalization through a form of political marketing. Through interpretive subjective approaches, qualitative methods, and descriptive juridical normative research types of laws and regulations that contain analog-to-digital migration substances as well as data collection techniques for normative studies, observations, and focus group discussions, this research finds a model of government political marketing in television digitization is carried out in stages using government structures, starting from the central government, provincial governments, to district/city governments. The television digitization model can be called the multiple levels of government model. Through this model, it is optimistic that the public's understanding of the digitization of television programs will be evenly distributed.
Implication of Tipping on Services (a case study on Restaurant and Hotel Services in Tasikmalaya)
Authors: Syafei M Yani , Rahadi Dedi Rianto , Sianturi Gabriel
Published: July 2024

Tipping in hotels and restaurants has become a custom in several countries. However, the outbreak of the Covid-19 pandemic raises questions regarding the willingness of customers to give tips in difficult times amid the spread of the Corona virus. Tipping is mandatory in some countries, although some countries prohibit tipping workers in fast food services and hotels. The purpose of this study is to determine the implication of tipping as a sign of appreciation given to workers of fast food restaurant and hotel who have provided satisfactory service. The method used in this study is a descriptive approach and a qualitative approach. The results show that tipping encourages workers to provide their best service to customers while at the same time motivating workers to give their best work performance. In addition, companies and workers can also find out whether customers are satisfied or dissatisfied while enjoying food at the fast food restaurant.
Preserving of Hornbill Bird through 3-Dimensional Animation Clips
Authors: Cahyadi A T , Fadillah R , Mulyana H , Ramdan Z F
Published: July 2024

Post-Covid-19 pandemic conditions, the use of digital technology in animation and multimedia can produce works that can be used as a solution to existing problems, especially in the conservation of the Indonesian Borneo hornbill. The design in the form of a film or animation clip aims to educate the importance of hornbill conservation. The method used in this study uses a qualitative descriptive method with data collection and data processing, in the technical implementation of the animation pipeline, namely the stages of pre-production, pre-production, and post-production. The results of this study have succeeded in using these stages and producing a video or animation clip entitled The Spirit of Ampong with three-dimensional techniques. It is hoped that the results of the design will have a positive impact on the conservation of the hornbill.
Adolescents' Knowledge and Perception of Traditional Food Products Typical of Banten Gipang PD Laila
Authors: Ekawardhani Y A , Maulia Holif
Published: July 2024

This study's aim was to find out how much adolescents in Banten Province knew about the brand of traditional snack gipang PD Laila and how they viewed the visual presentation of its goods. This study employed a descriptive methodology that included observation, personal conversation, and literature review. Gipang as traditional snack are thought to be impacted by modern trends relating to the creation of new companies and different sorts of snacks. According to the outcomes of direct discussion with the owner, PD Laila's gipang items are among those that conflict with these conditions. Teenagers were also given an online survey to complete about the traditional snack gipang, the product brand, and the packaging. The findings indicated that although most youths in Banten Province were familiar with the traditional gipang snack, they were unable to name the brand of gipang as traditional snack. The majority of respondents do not know the brand name of PD Laila's gipang traditional snack and have a negative opinion of the product packaging, which influences their decision to buy traditional cuisine. The marketing of PD Laila's gipang items needs to be updated because they are thought to not have an appealing presentation or appearance. The study's findings suggest that in order for PD Laila's gipang traditional snack products to be recognizable and draw in young people, package improvements and product advertising media are required.
The Effect of Business Communication on Employee Performance
Authors: Maulani Galih Abdul Fatah , Zahra Alfiyah Az , Hamdani Nizar Alam , Permana Intan
Published: July 2024

This study discusses an analysis of effect business communication on employee performance at PT JNE Express Across Nations. Researchers used quantitative methods with data collection techniques by questionnaires. Data quality analysis techniques used validity test methods, reliability tests, while hypothesis testing used simple linear regression analysis and t test. Based on the results of research conducted, business communication has a significant effect on employee performance. That way the results of this research can help companies and entrepreneurs to implement the business that is being occupied and can make it easier for future researchers to find the latest references if they have the same variables so that the research can be helped to be more perfect.
The Influence of Entrepreneurial Education on Entrepreneurial Intention within Indonesian Student
Authors: Mubarok Teten Mohamas Sapril , Martiara Dewina , Hamdani Nizar Alam , Permana Intan
Published: July 2024

The objective of this paper is to examine the effect of entrepreneurial education on entrepreneurial intention. Moreover, the paper examines how dimensions correlate with entrepreneurial intention. It is concluded that entrepreneurial education has a significant effect on entrepreneurial intention. This research has benefited that entrepreneurial education to carry out entrepreneurial intention. In addition, the study also finds a significant effect entrepreneurial education on entrepreneurial intention. The analysis of the paper is based on survey responses from 31 Indonesian student at high education
ANALYSIS OF INTEREST AND MOTIVATION TO LEARN JAPANESE AT SMK KESEHATAN RAJAWALI
Authors: Chandra Muhammad Fahmi Saputra , Arianingsih Anisa
Published: July 2024

This study aims to understand the interests and motivations that underlie learners' interest in learning Japanese as a foreign language, focusing on students who chose to major in Japanese as a subject. The method of this study used questionnaire and interview. This qualitative research took a case study of 20 student of 11th grade pharmacy students at SMK Kesehatan Rajawali in the 2023/2024 academic year. Four aspects of interest and two types of motivation were the focus of the research. The results show that respondents' interest in Japanese is quite high, with the element of fun being the most common answer. The fun aspect includes respondents' interest in all things related to Japan, such as anime, manga, culture, and career opportunities. Motivationally, it appears that the reasons expressed by respondents tend to be more related to integrative motivation. The emergence of this motivation is based on their interest in the language and culture.
ANALYSIS OF THE USE OF THE MINISTRY OF LAW AND HUMAN RIGHTS' SIMPEG APPLICATION INFLUENCES THE DIRECTORATE GENERAL OF IMMIGRATION'S PERSONNEL ADMINISTRATION SERVICES AT ONE OF THE IMMIGRATION OFFICES
Authors: Budiarti Isniar , Muhammad Faridz
Published: July 2024

This research aims to implement a management information system based on the SIMPEG application in providing services to the community. This research used a sample of 54 respondents at one of the directorates general of immigration at the Immigration Office. This research uses simple linear regression analysis and non-probability sampling techniques are used in the sampling method by collecting data through questionnaires, interviews and observation. The results obtained by the personnel management information system (SIMPEG) have a positive and significant effect on the personnel administration services of the Directorate General of Immigration at one of the Immigration Offices. This is because the resulting data reporting is in accordance with requirements. Apart from that, data in SIMPEG can be searched easily and the facilities available in SIMPEG are easy for employees to use, so that personnel administration services are better
GUILT EFFECT TO CHARACTER’S HARUMA SELF-DEFENSE MECHANISM
Authors: Dinata Yuda Prawira , Febrianty Fenny
Published: July 2024

This journal seeks to find out how guilt affects the self-defense mechanisms of the character Haruma in the manga Inu to Kuzu. The method used is descriptive qualitative to find out the influence of guilt on Haruma using findings from pictures and dialogue. Based on research findings, it was found that Haruma's character experienced a self-defense mechanism of repression, which made him forget memories of events that made him feel guilty
JUDICAL REVIEW OF PERPETRATORS OF PREMEDITATED MURDER COMMITED ON THE BASIS OF SUPERIOR ORDERS
Authors: Situmeang Sahat Maruli Tua , Aishah Diani Nur
Published: July 2024

This research delves into the judicial review of premeditated murder cases committed based on superior orders, using the case of former Chief of the Professional and Security Division of the Indonesian National Police, Inspector General Ferdy Sambo, as a focal point. The study aims to explore the legal implications, public perception, and standard procedures within the police force regarding subordinate compliance with superiors. Employing a descriptive analysis methodology, data was gathered through literature review from secondary and tertiary sources. The findings illustrate the intricate balance between accountability, legal principles, and ethical considerations in law enforcement. While acknowledging the necessity of punishment in criminal law, the research emphasizes the importance of accurately applying legal terms, especially regarding the element of premeditation, to ensure justice and uphold legal certainty. Recommendations include continuous education and training for law enforcement personnel to prevent errors and uphold ethical standards in the execution of their duties.
INDONESIAN MUSLIMAH INFLUENCER'S FASHION STYLE ON SOCIAL MEDIA
Authors: Ramadhan Gilang Aghistya , Ekawardhani Yully Ambarsih
Published: July 2024

This article aims to explain the fashion style of 3 well-known Muslim women influencers in Indonesia from a fashion perspective. The development of Muslim fashion is inevitable due to the increasingly massive distribution of technology in various layers of society. The more widespread internet also affects the flow of information about Muslim fashion. Influencers also flourish in line with the development of social media networks. The presence of Muslim influencers is able to boost the style or fashion sense of young people with a variety of interesting combinations in the use of motifs, colors or styles of clothing. Indonesia has 3 influential Muslim influencers in social media networks, because they have tens of millions of followers and excel in their fields. Among them are Laudya Chintya Bella, Zaskia Sungkar and Ria Ricis. The method used is with a descriptive approach, which is explaining result with the aim of validating the phenomenon that the author is researching. The results obtained from the 3 influencers are that the influencers have different visuals of Muslim clothing from one another, having their own distinctive styles both in the selection of styles, shapes or colors. This article can be a reference for young people who want to look trendy with the latest outfits without having to abandon their Islamic identity.
THE PERSONA OF THE MAIN CHARACTER IN THE NOVEL NINGEN SHIKKAKU BY OSAMU DAZAI
Authors: Nurhayat Putri , Febrianty Fenny
Published: July 2024

The novel "Ningen Shikkaku" by Osamu Dazai delves into the internal turmoil of Yozo Oba, its main character. This study utilizes Gustav Jung's theories to dissect Yozo's inner conflict and its psychological ramifications. Through qualitative analysis, the investigation probes into the interplay of archetypes, shadows, and complexes within Yozo's psyche, unraveling their impact on his character evolution. Yozo's struggle epitomizes a profound discord between his yearning for acceptance and his aversion to societal norms, leading to self-destructive tendencies, identity crisis, and social alienation. This examination unveils the intricate layers of Yozo's personality vis-a-vis Jungian analytical psychology, offering fresh insights into Dazai's narrative and its exploration of internal discord in literary context.
MEANING SHIFTS IN THE LYRICS OF TRANSLATED SONGS "EUREKA MILIK KITA" AND "SEVENTEEN" BY JKT48
Authors: Rawdhotunnimah Silmi , Ali Mohammad
Published: July 2024

This study aims to describe the shift of meaning in the lyrics of the translated songs Eureka milik kita and Seventeen by JKT48 based on the theory proposed by Vinay and Darbelnet (1965). The data source is taken from 2 songs in JKT48's Mahagita Vol.2 album which was released in October 2023 by Producer Akimoto Yasushi under the ownership of PT Indonesia Musik Nusantara by using qualitative descriptive research methods and note taking techniques. A deep understanding of meaning shifts in the translation process is important to improve the quality of cross-cultural communication and minimize the risk of misunderstanding. The results obtained are that overall there are 16 shifts in meaning. Of the 16 shifts, there are 7 modulations of meaning coverage, 1 modulation of viewpoint, 5 additions, and 3 deletions. In the song Eurika Milik Kita, there is no shift in the meaning of the Modulation of Viewpoint.