Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
Authors:   EuroSurg Collaborative, Chapman S J , Clerc D , Blanco-Colino R , Otto A , Nepogodiev D , Pagano G , Schaeff V , Soares A , Zaffaroni G , Žebrák R , Hodson J , Blanco-Colino R , Chapman S J , Glasbey J C , Pata P , Pellino G , Sgrò A , Soares A , Elst T , Van Straten S , Knowles C H , Nepogodiev D , Hodson J , Borakati A , Bath M F , Yasin I H , Mclean K , Arthur T , Kovacevic M , Delibegovic S , Karamanliev M , Swamad M , Žebrák R , Paramasivam R , Martensen A , Larsen H M , Rädeker L , Frey P E , Kechagias A , Venara A , Duchalais E , Ioannidis A , Pata F , Pellino G , Pasquali S , Sgrò A , Simioni A , Farina V , Podda M , Lorenzon L ,   ItSURG, Schaeff V , Otto A , Jakubauskas M , Elst T R , Chu M , Fagan P V B , Wells C I , Alagoa João A , Soares A , Juloski J , Clerc D , Ciubotaru C , Popescu S , Yanishev A , Lee S , Ozkan B B , Yagız Sen A , Aktas M K , Baki B E , Yüksek B , Glasbey J C , Kamarajah S , Mclean K , Borakati A , Yasin I H , Khaw R A , Mills E , Goodson R , Thakral N ,   STARSurg Collaborative, Ablett A D , Adra M , Kwek I , Khan S M , Quinn P , Manley L R , Badran A , Ramjeeawon A , Campbell A , Tan H L , Rye D S , Rajaraman N , Norman J G , Vutipongsatorn K , Solomou G , Akhbari M , Ali A , Murray V , Baker D M , Brandao B D , Stainer B , Thavayogan R , Jones D , Onafowokan O O , Gharooni A , Dabab N , Carlton-Carew S , Kungwengwe G , Gabriel M , Sewart E , Shortland T C , Lawday S , Pockney P , Dawson A , Arthur T , Brumfitt C D , Stewart P , Ng B , Luong J K , Delibegovic S , Ivanov V , Borisova A , Neykov V , Kunčarová K , Kološová B , Antonova T , Farkašová M , Žebrák R , Harbjerg J L , Brandsborg S , Brinck S , Kjaer M D , Mark-Christensen A , Unbehaun K P , Dalsgaard P , Lycke K D , Kechagias A , LeNaoures P , Duchalais E , Brigand C , Dumange E , Gout M , Moehwald C , Prem M , Alhalabi O , Sliwinski S , Krupp J , Gablenz E , Schmitzer L , Kopp A , Steinle J , Gsenger J , Pohl L J , Riccardi M , Christodoulou I M , Konstantinidis M , Machairas N , Zoikas A , Balalis D , Manatakis D K , Aguilera M L , Sgrò A , Simioni A , Marano L , Fleres F , Lovisetto F , Sasia D , Segalini E , Pata G , Lucchi A , Sagnotta A , Campagnaro T , Petrelli F , Gallo G , Papandrea M , Testa V , Sinibaldi G , Di Candido F , Colombo F , Perrone G , Aresu S , Biancafarina A , Canonico G , Pagnanelli M , Curletti G , Bini R , Manzoni Garberini A , Impellizzeri H , Cillara N , Tutino R , Picciariello A , Coletta D , Savino G , Ferrara F , Tamini N , Talamo G , Parini D , Giamundo P , lo Conte A , Pagano G , Ripetti V , Pesce A , Menduni N , Pellino G , Giudicissi R , Podda M , Goldin E , Rega D , Belli A , Andriola V , Gordini L , Pata F , Foppa C , Piccolo G , Birindelli A , Ferrari C , Ballarini Z , Tirelli F , Milone M , De Rosa M , Pipitone Federico N S , Molteni B , Tilocca P L , Sancini G , Piozzi G N , Lauretta A , Poillucci G , Mulas S , Schaeff V , Otto A , Jakubauskas M , Simcikas D , Portelli L , Wijnbergen J W M , Dinger T L , Doesschate S F H , Dalen A S H M , Bos D D , Hansmann M , Medina Feliz J , Kuiper S Z , Abdulrahman Z , Pruijssers S R , Farik S , Elliott B M , Geneta V P , Chu M , Wilton S , Kandelaki H , Peng S L , Campbell S , Lim Y K , Yassaie S S , Murray M , Fagan P V B , Haran C , Tan J , Castro J , Laranjeira A , Catarino S , Neves-Marques C , Correia J G , Vieira B N , Quintela A C , Serra M L , Maciel J , Cunha M , Aparício D J , Neves J , Azevedo J , Romano M , Eiró F , Romano J , Monteiro C , Claro M , Almeida M R , Peyroteo M , Machado N D , Capote H , Ferreira M , Sousa X , Devesa H , Cavadas D , Guerreiro I , Costa M , Salman M , English C , Mohammed N , Popescu S , Yanishev A , Litvin A , Ćuk V V , Mészárosová K , Van Straten S , Jaich R , De Lima H , Brooks S , Marx M , Nshalati Salvation M , Clerc D , Blaser B , Piazza G , Gagliardi B , Serin H , Yagız Sen A , Yurdaor S S , Aktas M K , Arslan E , Kopac O , Uyanik A , Ozmen B B , Tiftik E , Aksoy B , Yalcinkaya A , Ozoglu F , Kocer M D , Bilicen G , Cinar E N , Uslu Ö , Kaya Y , Wong J , Farhan-Alanie M M H , Suresh G , Asif A , Finch B J , Bhahirathan Y , Herron J , Yi Tew Z , Obukofe R , Russell C , Suchett-Kay I , Netke T , Williams L , Kisiel A , Liu F Y , Claireaux H , James P , Mondal A , Kalderon R , Nadama H H , Al-Saraff Z , Tam J P H , Powell-Chandler A , Wood F , Campbell A , Gorgievska Rebecca , Ragavoodoo A , Thakrar C , Rojoa D , Palmer C , Davidson K , Giacci L , Hale J , Gan F W , Makin-Taylor R , Hey C Y , Toh C , Findlay J M , Griffiths N , Ganesananthan S , Jasionowska S , Poustie M , Wong C , Turner T , Pyc W , Sloper W , Warner C , Coey J , Mason D , Sait S , Kowal M , Shortland T C , Owen M , Saiyed A , Ashworth I , Akbari K , Curran M , Martin P , Parker D , Dawson A , Kwok K , Lye C , Pockney P , Ghaly M , Sammour T , Lewis D , Mundasad R , Wilkes A , Ctercteko G , Stewart P , Delibegovic S , Maslyankov S , Dimov R , Iliev S , Dimitrov D , Marek F , Örhalmi J , Skalický P , Skalický T , Chrz K , Christensen P , Worsøe J , Kristensen E S , Emmertsen K J , Loeve U S , Duchalais E , Mihaljevic A L , Herrle F , Konstantinidis K M , Manatakis D K , Korkolis D , Karanikas I , Aguilera M L , Vincenti L , Anania G , Borghi F , Agresta F , Maretto I , Parisi A , Bucci L , De Palma G , Guglielmi A , Cucinotta E , La Torre F , Cianchi F , Guerrieri M , Lauretta A , Trompetto M , Persiani R , Micheletto G , Rega D , Belli A , Cantafio S , Lovisetto F , Ronconi M , Bisagni P A G , De Prizio M , Tamini N , Sinibaldi G , Franceschi A , Galleano R , Cavallini M , Brescia A , D'Ambra L , Benevento A , Niolu P , Calgaro M , Colangelo E , Grottola T , Altomare D F , Puleo S , Salamone G , Pietrabissa A , Poggioli G , Ripetti V , Erdas E , Ottonello R , Canonico G , Tonini V , Selvaggi F , Sammarco G , Ceccarelli G , De Nisco C , Surgo D , Taglietti L , Ozolins A , Sivinš A , Poskus T , Psaila J , Bemelman W A , Graat L J , Langenhoff B , Wijnhoven B P L , Ven A H W , Poelman M , Stassen L P S , Slooter G , Acherman Y I Z , Hoff C , Gerhards M F , Stommel M W J , Hazebroek E J , Geloven A A W , Schasfoort R A , Leeuwen B L , Tuynman J B , Tilburg M W A , Boerma E G , Sharma P , Jenkins B , Bissett I P , Peng S L , Herd A , Gordon A , Vernon D , Omundsen M , Ly J , Reddy A , Bonnet G , Harmston C , Morales M , Francisco V , Costa S , Manso A , Amorim E , Pereira J , Cardoso J , Ourô S , Caratão M , Nascimento C , Ribeiro da Silva B , Taranu V , Dias R , Devesa H , Mendes J , Allen M , Silva A , Carlos S , Barbosa E , Carneiro C , Ramos L , Maciel J , Lencastre L , Martins R , Silva-Vaz P , Ridgway P F , McNamara D A , Cahill R , Hogan A , Larkin J , O'Connell P R , Negoi I , Abelevich A , Ćuk V M , Vician M , Ede C , Sardiwalla I , Mulira S , Montwedi D , Oyomno M , Hübner M , Petermann D , Sauvain M O , Ozben V , Geçim I E , Disçi E , Rencuzogullari A , Kurt A , Bisgin T , Pehlivan M , Isik A , Onur E , Leventoglu S , Haksal M C , Erturk M S , Keskin M , Guner A , Tutcu Sahin S , Ozbalci G S , Pergel A , Albayrak D , Bruce D , Fearnhead N , Arthur J , Harron M , Beattie G , Titu L , Ali A , Saunders M , Phillips J , Dindyal S , Cresswell B , Gercek Y , Lee J , Linn T , Faulkner G , Lockwood S , Rees J , Charalabopoulos A , Campbell B , Kontovounisios C , Amarnath T , Johnson M , Epanomeritakis E , Vigs S , Nastro P , Gilliam A , Smolarek S , Wilson T , Orbell J , McIntyre R , Agarwal T , Hainsworth P , Patel P , Vijay J , Liu B , Dhruva Rao P , Roxburgh C , Vipond M , Youssef H , Thorn C , Schizas A , Denley S , Bowley D , Das K , Cuming T , Saha A , Chung L , Pitt J , Davis P , Jones O , Taylor M , Bhargava A , Haji A , Watson N , Bloom I , Singh B , Norwood M , Gurjar S , Stylianides N , Mirza S , Evans M , Williams G , Patil P , Hernon J , Finch G , Green S , Chapple K , Fafemi O , Warusavitarne J , Samee A , Carden C , Ong L , Verma K , Joseph A , Rawat N , Pinkney T , Oke O , Glen P , Maxwell-Armstrong C , Oliphant R , Garner J , Moug S J , Middleton S , Lund J N , Smart N J , Osborn G , Moore T , Raymond T , Knowles C H , Hany T S , Clarke R , Khera G , Brady R , Sellahewa C , Mason C , Torrance A , Lasithiotakis K , Knight J , Pullybank A , Ainsworth P , Reid F , Ramwell A , Maslekar S , George R , Skull A , Holtham S , Muhammad K , Lal R , Varcada M , Smith F M , Howlader M , Defriend D , Kirk S , Richards T , Evans C , Borg C , Telford K , Sarfraz N , Busby K , Hollingshead J , Speake D , Pawa N , West D , Chadwick M , Komolafe O , Richardson S , Thornton M , Goede A , Osborne C , Bandyopadhyay D , Foong J , Lee Y J , Liebenberg P , Mijalkov D , Wells A , Bull N , Ajmera A , Warburton T , Morgan S , Mahmoud A , Schachtel M , Mikhail B , Fomin I , Mekaeil B , Taylor N , Stevenson C , Drane A , Pahalawatta U , Lai L T , Debiasio A , Wong J , Jun H J S , Hengpoonthana R , Mendis D M , Robb P M , Lee H J , Wyche A A B , Davis L T , Lee H J , Chrimes A , Agarwal A , Zhao J , Williams S , Jayalath J M S N , Liebenberg P , Khor S , Muddasani T , Childs S , Ridgway S , Blefari N D A , Tam H , Puchalski N , Ngai C , Mackenzie J , Johnson N , Holmes M , Zuzek R , Saluja T , Gould T , Goh Y K , Selvaraj T , Brumfitt C D , Beh Y Z , Dudi-Venkata N N , Horne D , Borrow J L , Campbell C , Cousins G , Jackson L , Maheepala K , Zhao S , Holden E , Tutt L , Thompson B , Collins H , Louie F , Buckland B , Smith D , Chong C , Chua T H , Nayak C , Redmond J , Tan R R , Gramlick M , Teh J S , Ng S Y , Britten-Jones P , Mohd Rosli R , Pham H D V , Jegathees T , Coulter-Nile S M C J , Gosselink M P , Luong J K , Wang Y L , Maciaszek M , Chrapko P S , Nair A , Thirugnanasundralingam V , Muir K , Salibasic M , Pavlov V , Paycheva T , Borisova A , Lyulenina E , Kolev N , Ivanov V , Nguen D , Mitkov Y , Mitkov E , Vladova P , Dimitrov V , Hussain M , Gabarski A , Ivanov T , Yotsov T , Ilieva I , Karamanliev M , Akisheva A , Shoshkova M , Nawaz E , Feradova H , Mladenov T , Neykov V , Jozaf V , Farkašová M , Klail T , Pös M , Adel A , Sotona O , Bartoš M , Amjad T , Malý O , Berec S , Hanušová M , Hurný M , Riško J , Ludvik M , Stercz M , Treskoň R , Pospíšil M , Hlaváčová L , Kunčarová K , Tomanová D , Chodora S , Houdek O , Novický R , Antonova T , Sobotková K , Cha S , šuta Kimle K , Jirankova K , Bujda M , Paclík A , Trap A , Jürgens-Lahnstein J , Storm M , Dalsgaard P , Damgaard I , Olawi F , Ehlem F , Raos M , Kristensen F P , Lycke K D , Bønnerup K , Unbehaun K P , Kjaer M D , Brandsborg S , Amiri S , Enevoldsen M , Harbjerg J L , Højgaard Pedersen J , Jepsen B N , Hillgaard T K , Erichsen S B , Nielsen C V , Madsen C P , Bjerke J , Skejø C D , Aabling R R , Sørensen J S , Mark-Christensen A , Kechagias A , Turunen A , Katunin J , Niskakangas M , Vignaud T , Frey S , Ricolleau C , Chanut F , Magnin J , Gout M , Seiboldt T , Beck L , Pohl L J , Zamzow K , Betge F , Poncelet A , Truant M , Hauschild H , Neugebauer N , Schöning L , Simon S C S , Galata C , Karampinis I , Thäwel T , Seckler A M , Kerem C , Durdevic S , Ioannidis A , Antonakopoulos F , Konstantinidis M , Mathioulaki A , Chrysoheris P , Athanasopoulos P G , Kalles V , Spyrou I , Barkolias C , Paspala A , Machairas N , Papaconstantinou D , Spartalis E , Arkadopoulos N , Prodromidou A , Garoufalia Z , Balalis D , Zoikas A , Christodoulou I M , Mendez D , Rosales J , Flores M , Garcia M , Garcia A , Garcia M , Noriega Z , Torselli D , Aguilera M L , Rodriguez J , Lafranceschina S , Artioli E , Giaccari S , Nevoso V , Schimera A , Marino S , Geretto P , Pellegrino L , Borghi B , Sasia D , Marano A , Corino C , Cannata G , Giuffrida M C , Landra F , Pata G , Ongaro D , Baronio G , Raimondo S , Casiraghi S , Salvadori R , Savino G , Finotti E , Ciccioli E , Galgano A , Zuin M , Simioni A , Bettella A , Barina A , Vendramin E , Palano G , Schiavone D , Di Cintio A , Gemini A , Trastulli S , De Luca M , Sagnotta A , Desiderio J , Gubbiotti F , Cigognini M , Zaffaroni G , Maffioli A , Colombo S , Bondurri A , Sampietro G , Foschi D , Colombo F , Manigrasso M , Danzi M , Amato R , Anastasio L , Mastella F , Basile R , Peltrini R , Marra E , Luglio G , Pagano G , Giglio M , Manigrasso M , Anoldo P , Vertaldi S , Grimaldi L , Tammaro N , Pedrazzani C , Campagnaro T , Turri G , Lazzarini E , Conti C , Vulcano I , Bertilone E , Pintabona G , Viscosi F , Cerasari S , Galiffa G , Lapolla P , Coletta D , Del Basso C , Cirillo B , De Toma G , Fazzi K , Bini S , Coratti F , Montanelli P , Grandi S , Nelli T , Ben Khaled N , Cammelli F , Ferrini E , Billo M E , Tilocca P L , Marrosu A G , Scognamillo F , Pala C , Attene F , Carboni L , Ruggiu M W , Gabbas G , Marziali I , Mazzocato S , Petrelli F , Vergari R , Piazzai F , Kubolli I , Aggiusti A , Paolucci A , Ortenzi M , Olivieri M , Belluco C , Antona A D , Basso S , Morino M , Mistrangelo M , Testa V , Gallo G , Clerico G , De Santi G , Bitonti M F , Trompetto M , Pipitone Federico N S , Frattalone M , Tirelli F , Fico V , Santullo F , Belia F , Spinelli A , Marco M , Di Candido F , Bevilacqua M , Tringali D , Bevilacqua E , Panizzo V , Piozzi G N , La Manna V , Migliore G , Aversano A , Fares Bucci A , Marino F , Carbone F , Incollingo P , Romano F M , Giudicissi R , Zalla T , Baraghini M , Romoli L , Calussi M , Vellei S , Genzano C , Feroci F , Vita M , Barberis A , Serra D , Lucchi A , Grassia M , Romelli M , Ruggiero S , Percassi A , Ferrari C , Molteni B , Magri Piccinini A , Segalini E , Monti M , Magnoli M , Romano S , Gaetano P , Pilotta F , Baldassarre L , Perrone G , Bonati E , Aresu S , Saba A , Moretto G , Bacchion M , Impellizzeri H , Casaril A , Inama M , Creciun M , Ferrara F , Stella M , Gobatti D , Biancafarina A , Angelini M , Andolfi E , Miranda E , Scricciolo M , Provenza G , Cavallina G , Frezza B , Fontani A , Malatesti R , Pellicanò G A , Podda M , Anania M , Pulighe F , Cruccu A , Murru M L , Massaiu C , Balestra F , Pazzona M , De Nisco C , Giannella A , Santangelo M , Olivieri M , Frangella F , Magagnano D , Liberatore P , Brenna R , Giani A , Tirotta F , Famularo S , Angrisani M , Ceresoli M , De Rosa M , Rondelli F , Ceccarelli G , Angelucci G P , Scaramuzzo R , Larcinese A , Fioriti C , Picone E , Nardi M , Marano L , Castagnoli G , Bartoli A , Bellochi R , Spaziani A , Conti D , Poponesi V , Trippetti M , Amicucci S , Tazza G , Procacci P , Giovannini F , Basile E , Franceschi A , Caristo G , Pagnanelli M , De Nardi P , Rosati R , Marcocci G , Vignali A , Curletti G , Galleano R , Badran A , Malerba M , Percivale A , Ghazouani O , Reggiani L , Spirito C , Moschetta G , Cosmi F , Romeo G , Gasparrini M , Sucameli F , Gennai A , Moggia E , Bianchi C , Bonfante P , Macina S , Feleppa C , Talamo G , Imperatore M , Tenconi S M , Rausei S , Maioli D , Marchionini V , Pata F , Sparta C , Mura F A , Barmina M , Lorettu A , Rettaroli C , Mastino G , Ruggiu G V , Mura G A , Perrone B A , De Angelis M , Mereu A , Adamo V , Bianco C , Manzoni Garberini A , Ricciardiello M , Campanaro C , Panaccio P , Esposito L M , D'Ascanio F , Pietroletti R , Picciariello A , Chetta N , Aquilino F , Di Marco F , Amico A , Schembari E , Puglisi S , Licari L , Campanella S , Profita G , Falco N , Rotolo G , Venturelli P , Tutino R , De Marco P , Marcianò M , Sgrò A , Argenti F , Milani M S , Malabarba S , Giambartolomei G , Vella I , Gronchi F , Ruggieri A , Sancini G , Roggiani A , Balsamo F , Gori A , Cuicchi D , D'Alessio R , Benvenuto D , Gordini L , Erdas E , Podda F , Cappellacci F , Salaris C , Sanna S , Marcialis J , Mosino L , Peddis M , Melis S , De Donno G , Aru A C , Falsetti E , Parini D , Lanari J , D'Errico U , Bianchini S , Birindelli A , Figà F , Caiazzo A , Selvaggi L , Capozzolo A , Cerra C , Pirillo M , Papandrea M , Cravano S , Libri I , Laquatra N , Isabello A , Truškovs A , Bartnick A , Malcevs E , Machatschek M J , Alm J , Lapsa S , Delorme M , Zeynalov F , Larnovskis J , Sauka J , Bodrov D , Gailumsis R , Wiemann A M , Müller N L , Jelovskis I , Deksnis D , Bauermeister Potts O , Slimbajevs T , Samalavicius N E , Simcikas D , Nutautiene V , Zeromskas P , Jurgaitis J , Aliosin O , Slepavicius A , Eismontas V , Kybransiene M , Dulskas A , Kuliavas J , Kavaliauskas P , Kavaliauskaite R , Poškus E , Danys D , KryŽauskas M , Mikalauskas S , Rackauskas R , Drungilas M , Poškus T , Jotautas V , Strupas K , Cachia C , Cefai C , Portelli L , Youssef Y , Degaetano D , Debono S , Sammut M , Cassar J , Sammut K , Looyen R , Dalen A S H M , Becker M A J , Comert D , Molder L , Tromp J , Matthee E , Tissen Y M , Brinkhuis E , Vries H S , 't Hart E , Beckers K , Bekker Y , Kakar S , Doesschate S F H , Smaalen T C , Veen O C , Dingemans S A , Brink L C , Vijgen G H E J , Voort E M F , Pool A , Rest K L C , Haak T , Sluijpers N R F , Pruijssers S R , Molenaar C J L , Gordinou de Gouberville M C , Saleh S , Mens M A , Hoeks E M , Nieuwenhuizen S , Praag E M , Westerduin E , Smit M P C M , Lely S J , Nasimi B , Gerdsen M , Stijns R C H , Leow T Y S , Penningnieuwland G , Ruiter A , Ribbers T , Aarts C A M , Tulek M S , Jonge J , Kocak S , Alqethami H J , Constansia R , Elst P C , Tissink M W , Grüter A , Vroom Y , Voeten D M , Feenstra T , Azzahhafi J , Bofarid S , Kip M , Saleh W , Franssen S , Boon C L , Franssen R J M , Romaen I , Jense M T F , D'Souza J , Pascoe R , Scott A , Stark E , Mulholland K , Lau W K , Smith B , Adams S I B , Shah N , Ling E , Young J , Peng S L , Jacobson A , Macfater H , Farik S , Chen S Y , Kilpatrick K , Kim D H , Dixon S , Yassaie S , Welman D , Coulter J , Morreau M , Li E , Rankin A , Winders J , Skipworth C , Fagan P V B , Stanfield B , Henderson N , Chuang A , Maskill L , Ker H , McLaughlin S J P , Kearney J , Wilton S , Sprosen H , Kerckhoffs P , Alsadat R , Cherry R , Chapman D A , Singh N , Clucas A , Gatenby G , Kelly B , Ruppeldt P , McIntosh N D , Koh S , Wilms H , Dalzell F , Tewhaiti-Smith J , Kader T , Yam S T , Dahya D , Hardie Boys M , Fleischl W , Tan J , Skavysh A , Mouldey K , Elliott B M , Hu R , Edwards S , Matthews C , Aitken E , Walker M , Guerreiro I , Tomé M , Patrocinio S , Amado F , Batista A , Seabra J , Praxedes V , Monteiro N , Martins I , Serra M L , Santos T C , Lages R R , Pimentel A , Machado N D , Sá T C , Bernardes F M , Saraiva P , Almeida J , Mendes M , Fernandes V , Ribeiro A , Soares D , Costa M , Rosete M , Martins T , Miguel I , Martins J , Cunha M F , Melo J , Veiga D N , Rachadell J , Amorim E , Vareda R , Roseira J , Catarino S , Aveiro D , Couto M , Loureiro A R , Louro H , Queiros T , Castro B , Fonseca S , Carvalho L , Torre A P , Amado A , Leite M , Miranda P , Cunha C , Ferreira M , Cavadas D , Silva R , Pina S , Paixão I , Orelhas L , Santos J , Pacheco A , Rocha A F , Jervis M J , Pedro V , Paixão V , Guerreiro A , Melo D , Correia D , Capella V , Moinhos T , Monteiro C , Silva M , Vieira B N , Silva A G , Galvão D , Mora A , Bettencourt R , Costa F , Gil I , Morgado J , Neves J , Mónica I , Oliveira S , Ribeiro H , Ferreira M , Guimarães N , Duarte M , Miranda J , Martins S F , Almeida M R , Parreira R , Faustino A , Medeiros N , Castro R , Soares B , Resendes M , Almeida P , Cruz A , Claro M , Vaz Pinto G , Sousa D , Costa Santos D , Silva A , Silva F , Fialho G , Reia M , Pratas N , Capote H , Costa C , Costa J , Morais S , Machado A , Horta V , Rocha-Melo M , Patrício J , Pereira M , Lima R , Cinza A M , Oliveira J , Velez C , Ferreira M , Borges F , Simões J , Eiró F , Botelho P , Cismasiu B , Alves D , Dias B , Costa C , Gonçalves J P , Valente P , Oliveira J , Freire L , Saraiva R , Moreira M , Fragoso M , Guimarães J , Cruz G , Aparício D J , Ribeiro J , Borges da Ponte I , Almeida S , Martins A R , Louro T , Morgado M , Ferreira A S , Alves M , Oliveira N , Lérias R , Neves-Marques C , Estalagem I , Botelho C , Bártolo J , Fidalgo Antunes C , Cabral F , Brito Silva F , Dias Matos A , Santos M , Cunha R , Duarte M , Sousa M , Canotilho R , Peyroteo M , Correia A M , Martins P C , Jardim J A M , 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Gavrilina A , Barkovskaya A , Kudelkina N , Topchubaev D , Radulović R , Miloševic K , Ćuk V V , Bojičić J , Juloski J , Genčić M , Janković U , Zubowicz M , Sucháň P K , Gerstmeier J , Mészárosová K , Brazitikou E , Fytrou E , Celik M , Dubovský M , Schmalenbeck J , Sautter S C , Ceyran H , Jaich R , Fitchat N , Mathebula S , Chauke J , Mculu W , Ngwenya Z , Withey K , Piperidis A , Toyi Y , Nicolaides A , Jaffer T , Sparke A , Van Staden N , McDuling C R , Claassen L , Kruger C , Weyers J , Marx M , Lecler J , Mignon G , Vanoni A , Henkens A , Jarrar G , Odovic M , Willemin M , Milliet O , Hahnloser D , Clerc D , Demartines N , Piazza G , Teixeira H , Pittet O , Haller M L , Gagliardi B , Huot A , Blaser B , Kefleyesus A , Bugmann A , Piotet L M , Meijers L , Kurtoglu G K , Sel E K , Isler V C , Yilmaz B S , Adiyaman C , Kara M , Demirkaya H C , Korkmaz H K , Pektas A M , Güner B , İşlek E C , Tombul H B , Boztuğ C Y , Tınaz A , Yılmaz M , Karaman Y , Akın F A , Dansuk S , Başçavuş M 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Dunmore C , Aitken G , Nair M , Aly M H , Buari M , Farhan-Alanie M M H , Ahmed K , Sheikh Z , Monks M , Lehmann J , Rotimi O , Bell T , Limnatitou D , Gormley S , Taleongpong P , Patel V , Macgregor L , Amini S , Turner C , Dwyer-Hemmings L , Busuttil A , Powell J , Hensher C , Vivian F , Wcislo K , Millar Z , Hirosue S , Ogunmwonyi I , Nakakande D , Kwek I , Gaze H , Nirmalanantha A , Bin Amran A M , Foulkes A , Jones N , Pillai S , Khoury G , Powell T , Maleyko I , Sangheli A , Ransome M , Isse M , Aromolaran O , Bholah H , Anbarasan J , Rehman S , Hu E , Timms S , Reynolds W , Hotchkies A , Misra V , Suresh G , Murray V , Theocharidou L , Malik T , Janmohamed I , Carhart B , Khan A , Asif A , Hullait R , Quinn P , Rylance A , Butt S , Leathes J , Finch B J , Philip Rajathasan T , Jeddy H , Kyaw H A , Wong N , Karelia S , Clements J M , Rainey M , Joshi N , Rahman A , Gallagher M , Rebuffa N , Abdelgalil R , Siaw Yen Lai R , Laurence N , Thomas S , Green C , Frostick R , Khera R , Povey M , Wong H L , McCusker C , Hlukha L , Pike G , Kamel F , Thakkar R , Donaldson C , Sequeira Campos M , Bhahirathan Y , Armitage M N , Hussain A S , Hardy B , Hassan Serry M Y , Herron J , Bradbury M , Osunronbi T , Tam L Y C , Khanan Kaabneh A , Lawther J , Fisher P , Tribedi T , Moosa A , Ramdin A , Goble M , Downs E , Wheldon L , Baggus E , Mandal A , Nayeem A , Ahmed S , Fradley W , Wilson C , Gallagher S , Criswell T , Ward J , Mukkavilli A , Stubbs B , Fordyce W , Suchdev N , Wei Lim S , Yi Tew Z , Sookramanien S R , Chan A , Bointas G , Paul M , Ward K L , Bagnall M , Pherwani S A , Wang K , Mitchell L , Heyworth J , Ayyar S , Obukofe R , Polson R , Mason D , Mackenzie E , Russell C , Doyle N , Habib Z , Zardab M , Sartaj F , Farooq H , Tabibi M , Drury D J , James S J , Barnett R , Teasdale A B , Richardson E T J , Thomas D A , Ahmed S , Williams R L , Najabat-Lattif H F , Cahya E , Lou G , Coyle M , Homyer K , Zhu L Y , Woods M , Chang J , O'Callaghan H , Suchett-Kaye I , Mihailidis T H , Alawattegama H , Seite E , Barrett A , Riordan E , Lam W , Dowdeswell M , Mulvenna C , Netke T , Awokoya O , Gurowich L , Dhera K , Hayat S , Williams L , Tincknell L , Spazzapan M , Teeling F , Sysum K , Latter J , Latter M , Khan S , Guruswamy M , Beedham W , Brazier E , Elghobashy M , Bajaj M , Mann H , Etel E , Woodmass M , Hayden H , Kisiel A , Ali Y , Husain S , Arnold A , Pedersen A C , Cunha P , Ahmed M , Al Zawawi S , Kudva V , Liu F Y , Theodoropoulou K , Miscampbell M , Robinson A V , Johnston J , Dharni A , Lamb S , Westerman T , Evans E , Campbell L , Gillespie M , Cheong C M , Kulathevanayagam K , Varghese A , Ike S I , Chu T S M , Baljer B , Mogg J A W , Rai P , Claireaux H A , Williams M , Smillie R , Goetz J , Appleby E , Fadipe T , Vaughan-Burleigh S , Puri G , Hussain P , James P , Flather R , Cutler A , Pathak S , Sheldon J , Collicott T , al-Ausi M , Mondal A , Jovaisaite A , Shah S M , Khalid N , Gutmann D , Davison S , Alame Y J , Syed L , Owen W J , Ahsan S D , Kalderon R , Anthony-Uzoeto U , Macleod Hall C , Zheng S , Wynter K , James C , Sapre D , Ghosh R , Baird J , Cockburn L , Blackwood O , Nadama H H , Simpson W , Jeong S , Bishop S , Bate R , Hobson C , Adam A H , Redclift C , Do J , Adeleye O , Poli F , Batterham A , Brown S , Parekh J N , Clay W , Pieri K , Jackson A , Brown S , Saxena A , Gurung B , Oyebola T , O'Brien F , Djeugam B , Gardezi S , Ul-Hasan S , Martin-Hernandez M P , Sisley M , Modi S , Antakia R , Elbayouk A , Soh Y J , Mather J , Yusuf Z , Al-Sarraf Z , Naja M , Rassool S B , Convill J , Nikookam Y , Warsame A , Tam J P H , Pace C , Kiandee M , Ridwan R , Carey C , Hirri F , McMillan M J A , Ling J J , Powell-Chandler A , Pendelbury L , Kerimzade K , Tang A , Howard E O , Humayun S , Wadsworth O J , Tan K , Abdelhameed F , Haglund C , Radnaeva I , Hu N , Rambhatla S , Waldron D , Madahar P , Malik S , Campbell A , Meney L C , Ibrahim I , Kang C K , Chiu J Z J , Livie V , Ibrahim B , Khalil M , Pooley G , Shishkin B , Gorgievska R , Docherty J , Southgate A , Coomes A , McGee F , Flanagan S , Thakrar C , Tan Q J , Anwar H , Clough R , Chrisp B , Cassels J , Cross G W V , Ragavoodoo A , Mercer L , Mercer C , Refalo A , Hadley R , McTighe A , Farrow F , Brodie A , Davis G , Shah D R , Bowers C , Patel S , Morice O , Burzic A , Cheung J , Shashidhara A , Theodoraki G , Birk J , Ong A , Ng M P E , Wong R T W , Maese S , Yeap B , Iqbal Z , Rojoa D M , Cabaleiro Barciela C , Hussain M , Ruddy C M , Lindwe S , Qamar Y , Chuita S , Melaugh T , Hall J D , Palmer C , Kouli O , Hassane A S I , Azhar A W , Tan T K , Perchard W , Scurr T , Davidson K , Campbell E , Kelk L , Ghosh A , Gibbins A , Mala D , Loizidou A , Hall O , Mecia L , Hew C , Varathan K , Tong L , Chandrasekar B , Giacci L , Buchanan E , O'Connell M , Kwak S Y , Ong E H , Gardner S , Lim J , Maden C , Illahi M , Hale J , Xuan Tan Z , Edwards S , Stahl R , Stahl J , Hickman A , Collett D , Goolam-Mahomed Z , Allen B , Atiyah A , Ahmad H , Jones J , McGregor O , Ogundiya E , Gan F W , Boulbadaoui A , Kirnon-Jackman O , Lim Q X , Peckham H , Yeoh T , Yong S Q , Chen J Y , Siva S , Sam Z H , Gilani M , Goh Y N , Muthukumar M G , Phillips S , Makin-Taylor R , Tjoakarfa J , Giri A , Suresan S , Thavayogan R , Hey C Y , Thomas P , Johnson T A , Williams R I , Rashid A , Kushairi A , Rais A , James A , Bugelli M , Chechelnitskaya Y , Sandhu N , Toh C , Tandon R , Gray M , Kumar A , Ciurleo C , Nyamali I , Hiremath S , Sinha S , Chowdhary M , Bradley E , McTiernan M , Macdonald S , Sharkey S , McLaughlin N , Amey C , Kraria L , Skan O , Kind C , Findlay J M , Tupper P , Van Rhee C , Honeyman S I , Menon G , Ahmed M , Jegatheeswaran L , Griffiths N , Madhavan A , Warne M , Malcolm F L , Lessware T , Wilkerson H T , Chatterjee-Woolman S , Yoong A , Ahmed W U R , Longshaw A , Flannery O , Green R , Leaning M , Cragg J , Sharriff H , Doherty C , Ganesananthan S , Kwan K W L , Sanders-Crook L , Bhatia S , Eames S , Lewis F , Kirupananthan P , Boh Z Y , Dass S , Soma A , Newton A , Hill M , Shafiq Y , Brkljac M , Boyce L , Jasionowska S , English W J , Lam S , Chipeta C , Yilmaz D , Jain C , Garofalidou T , Novotny S A , Locke S , Bowman C , Begaj A , Murphy C , Radcliffe K , Chong J T , Poustie M , Jeffrey E , Chaudhury N , Rajendran K , Akbar Z , Walters B , Kulendrarajah B , Tran N , Shrestha S , Parmar S , Gallagher C , Hennessy L , Pentti E , Badhrinarayanan S , Fung A , Mansoor M , Kenny R , Kan P , Lee D E , Khosla S , Samake M , Shaban F , Aftab R , Gough M , Woodburn B , Vayalapra S , McMurrugh K , Wong C , Jimulia D , Deol S , Pike S , Embury-Young Y , Turner T , Patel M , Kilgallon E , Keating R , Walsh A , Khan H , Logue G , Orekoya M , Alasmar M , Charalambides M , Clavé Llavall A , Williamson E , Bharwada Y , Zearmal S , Evans H , Panikkar M , Cruz G , Caplan J , Ruparelia A , Tanvir T , Soare C , Pang Y L , Trotter J , Zaidi A , Thakrar V , Pulickal P , Ahmed H , Parnell J , Khan H , Lennock S , Ford V , Pyc W , Brignall R , O'Neill D , Hanna R , Kane R , Nicola M , Rajput K , Xiao Y , Warner C , Michael S , Wright E , Juniper S , Thompson E , Hoskyns L , Kanitkar A , Ross C , Unsworth A , Rshaidat H , Demarre K , Chiang A , Bareh A , Dellen J , Faqihinejad C , Gadhvi A , Grant R , Lewsey J , Morris A , Martin H , McClarty C , Sanyal S , Alsaif A , Palkhi A , Bhopal S , Vishnu K S , Papanikolaou A , Mitra A , Nur A , Ali F , Burford C , Huq T , Sloper W , Irwin E , Matthews L , Ngu W S , Hosfield T , Muneeb F , Page O , Zeb E , Coey J , Al-Azzawi A , McIntosh J , Vucicevic A , Hughes M , Brooks L , Fanibi B , Dixon M , Njoku P , Morris D , Jobson J , Chowdhury H , Alawode D O T , Wynell-Mayow W , Udayachandran V , Alsoof D , Ekert J , Joseph N , Zulkefley N , Hunt G , Christodoulou T , Wright O , Soman S , Jamal M , Beqiri S , Borgas P , Christie S , Pereira F , Browne S , Yiu J , Dworkin A , Brayley J , Palmer A , Charalambos M , Jones C J , Toner S , 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, Rosete M , Americano M , Santos M , Frade S , Senhorinho R , Peixoto R , Alagoa João A , Alves-Vale C , Lamas M , O'Connor D B , Hoo M , Gopaul A , Scanlon K , O'Dwyer N , Negoi I , Jovanović M , Panyko A , De Lima H , Van Vuuren S , Curchod P , Gaspar S , Imadalou L , Mutlu D , Akyol C , Uygur F A , Eray I C , Biyiklioglu O , Çetin M F , Isik A E , Karip B , Dogan H , Sarıgül L , Tunc E , Aydin T , Bodur S , Karabulut K , Francis A A , Al-hadithi A , To N , Lau I S F , Smith E , Mahapatra S , McAuliffe O , Francis A A , Imam L , Akram B , Hossaini S , Davies R , Ko M , Collins J , Pandya A , Reilly S , Archer J , Auty C , Roche C D , Livie J , Chaudhry F A , Ntakomyti E , Diallo R , Bylinski T , Wright J , Lawday S , Masiha E , Tung J , Shirazi B , Neilson A , Epton S , Patel N , Trussell S , Couldrey A , Donnelly C , Eftychiou S 
Published: October 2019

Background

Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.

Methods

A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury.

Results

A total of 4164 patients were included, with a median age of 68 (i.q.r. 57–75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1–3, of whom 1061 (92·0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P &lt; 0·001).

Conclusion

NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement.