bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerokaan Amalan Pengajaran Terbaik dalam Meningkatkan Kemahiran Menulis Bahasa Arab: Satu Kajian Perspektif Guru Bahasa Arab di Daerah Temerloh Pahang
Authors: Hussain Yasmin , Abdul Ghani Mohammad Taufiq
Published: June 2024

Abstrak: Kemahiran menulis bahasa Arab merupakan aspek penting dalam pembelajaran bahasa dalam kalangan pelajar. Kajian ini bertujuan untuk meneroka amalan pengajaran terbaik yang dapat meningkatkan kemahiran menulis bahasa Arab dalam kalangan pelajar di daerah Temerloh, Pahang. Fokus utama adalah pada perspektif guru bahasa Arab yang berperanan penting dalam memberikan panduan dan sokongan kepada pelajar. Kajian ini merupakan kajian kualitatif yang melibatkan seramai 10 orang guru bahasa Arab di Sekolah Menengah Agama (SMA) di daerah Temerloh, Pahang sebagai peserta kajian. Peserta kajian dipilih dengan menggunakan teknik persampelan bertujuan. Protokol temu bual separa berstruktur digunakan sebagai instrumen utama kajian ini bagi mengumpul data. Seterusnya, data yang diperoleh dianalisis secara tematik dengan menggunakan perisian ATLAS.ti. Hasil dapatan menunjukkan bahawa aktiviti pembelajaran abad ke-21 (PAK21), bimbingan proses dan penilaian bermakna merupakan amalan pengajaran terbaik yang dilaksanakan oleh guru bahasa Arab dalam usaha meningkatkan kemahiran menulis bahasa Arab dalam kalangan pelajar.
 
Abstract: The proficiency in Arabic writing skills is a crucial aspect of language learning among students. This study aims to explore the best teaching practices that can improve Arabic writing skills among students at Temerloh district, Pahang. The primary focus is on the perspectives of Arabic language teachers who play a vital role in providing guidance and support to students. This qualitative study involves 10 Arabic language teachers from Islamic Secondary Schools (Sekolah Menengah Agama) at Temerloh district, Pahang, as participants. The participants were purposively selected using a targeted sampling technique. A semi-structured interview protocol was employed as the main instrument to collect data. Subsequently, the obtained data were thematically analyzed using the ATLAS.ti software. The findings indicate that 21st-century learning, meaningful guidance processes, and assessment practices are significant teaching practices implemented by Arabic language teachers in enhancing Arabic writing skills among students.
Estimation of Bond Strength based on Corroded Hinge Beam Specimens: Assessment of Design Guidelines and Analytical Models
Authors: Bhushan Bharat , Arora Harish Chandra , Kumar Aman , Kumar Prashant , Sharma Surabhi , Sharma Madhu
Published: June 2024

The bond between steel and concrete enhances the structural integrity of the building and ensures a cohesive force-resistant system, facilitating composite action between the rebars and concrete. This composite action, in turn, ensures the longevity of the reinforced concrete (RC) structure. The current study focuses on evaluating the performance and comparing design guidelines and analytical models pertaining to hinge beams and pull-out test specimens. The bond strength between concrete and steel was determined by validating 124 experimental datasets collected from the literature. These datasets were based on hinge and pocket beam specimens with varying degrees of corrosion. To facilitate comparison, the international design guidelines and analytical models were designated as G-1 and G-2, respectively. The results indicate that Model M-6 from G-1 and Model M-10 from G-2 outperformed all other models within their respective groups. Upon comparing these two models, M-6 appears to be superior based on selected performance indices. Model M-6 demonstrated an R-value of 0.3275, MAE of 2.29 MPa, RMSE of 2.76 MPa, and MAPE of 39.12% sequentially. Additionally, sensitivity analysis based on the collected dataset was conducted to assess the impact of each parameter.This study offers a comprehensive analysis of bond strength between steel and concrete in RC structures, focusing on hinge beams and pull-out test specimens with varying degrees of corrosion. It introduces superior models for performance evaluation and comparative analysis, highlighting Model M-6 as a novel and robust approach with significant potential for enhancing structural design guidelines.
Uma breve discussão sobre a homoafetividade em obras da Literatura Brasileira
Authors: Santos de Assis Lucas , Monteiro de Melo Neto Moisés
Published: June 2024

Perseguidos arduamente, pessoas homoafetivas suprimiam e ainda suprimem seus desejos. Atualmente, a comunidade LGBTQIA+ conseguiu alguns direitos de cidadania, mas ainda há o medo do retrocesso e, constantemente, sofre com os atentados de grupos preconceituosos. Este artigo apresenta uma breve discussão sobre algumas obras da Literatura Brasileira que discutem a temática da homoafetividade. O trabalho é resultado de uma pesquisa bibliográfica de cunho qualitativo, iniciando-se com um apanhado histórico da homoafetividade no Brasil, da colônia até os dias atuais; partindo para uma discussão sobre os conceitos homoafetividade e/ou homoerotismo, que discorre sobre como a relação entre pessoas do mesmo sexo é mais uma manifestação do desejo humano; Em seguida, são debatidas e analisadas algumas obras brasileiras tematizadas pela homoafetividade.
Palavras-chave: Homoafetividade. Homoerotismo. LGBTQIA+. Literatura brasileira.
Microfísica da morte
Authors: Vasconcellos Monteiro Rosa Carlos Frederico , Regueira Monteiro Rosa Jurema
Published: June 2024

Este artigo tem o objetivo de analisar os pormenores do ato de matar no Brasil, descrevendo a microfísica da morte no país. Para isso, foram observados, com base em dados e informações secundárias, comportamentos que findam em homicídios, bem como aspectos culturais e religiosos que se relacionam com a violência. Manchetes dos principais jornais das cinco regiões do país destacam a insignificância da vida, expondo a banalidade com que é tratada a morte no Brasil. Por fim, fizemos uma comparação entre as mortes provenientes da criminalidade com aquelas cometidas por pessoas até então sem envolvimento com o mundo do crime, e vimos que estas são responsáveis pela maioria dos assassinatos no país. Logo, concluímos que um dos principais fatores que colocam o Brasil no topo do ranking dos países mais violentos do mundo é o grau de civilidade da população e a ausência de alteridade nas relações humanas.
Palavras-chave: Microfísica. Morte. Insignificância da vida. Civilidade. Violência.
Um episódio na praia
Authors: Oliveira Luciano
Published: June 2024

Partindo de um episódio ocorrido na praia com ele próprio, em que o autor confundiu um patrão (negro) com o seu empregado (branco), o artigo discute, numa primeira parte, a pertinência de considerar como atos de racismo equívocos desse tipo, devidos não a um menosprezo em relação aos negros, mas ao fenômeno conhecido como “discriminação estatística”. Numa segunda parte, discute a pertinência de se considerar como falas racistas o uso de termos e expressões que, seja na sua etimologia, seja na sua semântica (como é o caso do verbo “esclarecer” e seus derivados), nada permitem considerar que tenham origem em práticas racistas ou cujo uso indique um preconceito de cor.
Palavras-chave: Racismo. Discriminação estatística. Falas racistas.
Nota Editorial
Authors: Sobreira de Moura Alexandrina
Published: June 2024

Escrever sem fazer concessão ao fácil e se expressar com clareza é cultivar a essência do pensamento e a originalidade dos temas. Autores conferem estilos pessoais e inconfundíveis à visão de mundo que abrange debates filosóficos, literatura política, papel das mulheres empreendedoras do Afeganistão, ensaios sobre racismo e a cultura brasileira, que estimula a criminalidade. Essa amplitude tem sido, há 51 anos, a marca da Revista Ciência e Trópico, um dos periódicos mais antigos da América Latina. Em diversos matizes, autores, ao longo do tempo, ratificam o pensamento de Manuel Bandeira, de que não querem mais saber do lirismo que não é libertação.
Com a reflexão suscitada pela leitura dos artigos, reafirma-se que a questão da vocação do escritor, como menciona o mineiro Murilo Mendes, está ligada ao mistério da própria vida e da criação. A literatura, pois, demonstra um modo de exteriorizar a revolta diante do convencionalismo e do farisaísmo do ambiente social que nos cerca.
ФОРМИ І МЕТОДИ ОЦІНЮВАННЯ РЕЗУЛЬТАТІВ СФОРМОВАНОСТІ ОПЕРАЦІЙНИХ ТА ПРАКТИЧНИХ УМІНЬ УЧНІВ НАУКОВИХ ЛІЦЕЇВ (ВІТЧИЗНЯНИЙ ТА ЗАРУБІЖНИЙ ФОРМАТ)
Authors: Тадеєв Петро , Тадеєва Марія
Published: June 2024

У статті досліджено вітчизняний та зарубіжний досвід використання форм і методів оцінювання результатів сформованості операційних та практичних умінь учнів наукових ліцеїв. Доведено доцільність використання для проведення ретельної та справедливої процедури оцінювання сформованості операційних і практичних дослідницьких умінь учнів наукових ліцеїв у вітчизняній та зарубіжній практиці таких основних типів оцінювання, як от: оцінювання досягнень учнів (Achievement Assessment), оцінювання процесу та результатів виконаного учнем завдання (Performance Assessment), цілісне оцінювання (Holistic Assessment), оцінювання учнівських портфоліо (Portfolio Assessment), зовнішнє незалежне оцінювання, яке має зарубіжний аналог Standardized Achievement Test. Констатовано, що, незважаючи на універсальний характер форм і методів оцінювання результатів навчальних досягнень, у кожній країні цей процес характеризується своїми особливостями і впливом національних освітніх традицій. Доведено, що при оцінюванні різних типів навчальних досягнень учнів необхідно враховувати такі чинники: якість знань (системність, глибина, осмисленість, міцність, гнучкість); характеристики відповідей учнів (повнота, логічність, обґрунтованість, правильність); ступінь сформованості базових та предметних умінь і навичок; рівень володіння розумовими операційними вміннями (аналіз, синтез, порівняння, абстрагування, класифікація, узагальнення, формулювання висновків); досвід творчої діяльності (вміння виявляти проблему та розв’язувати її, формулювання гіпотези та самостійність оцінних суджень). Розглянуто вимоги до оцінювання рівня сформованості дослідницьких операційних та практичних умінь учнів вітчизняних наукових ліцеїв на прикладі вивчення іноземної мови (англійської), яка служить основним засобом формування іншомовної комунікативної компетентності і є предметом гуманітарного циклу, та предметів шкільного курсу математики (алгебри та геометрії), які є базисом для формування логіки суджень, креативного і критичного мислення, так як ці обидва предмети шкільної програми відіграють ключову роль у всіх видах дослідницької роботи учнів, які навчаються у закладах шкільної освіти наукового спрямування. Визначено, що оцінювання рівня сформованості таких видів дослідницьких умінь учнів здійснюється за результатами перевірки їхніх навчальних досягнень у формі індивідуального, групового, фронтального опитування і в процесі виконання самостійних, контрольних, тематичних, проєктних робіт та тестування. При цьому заклад освіти може використовувати на свій розсуд поряд з традиційними й інші форми оцінювання освітніх здобутків учнів.
Diseño orientado a las prácticas sociales
Authors:   Universidad del Azuay, Tripaldi-Proaño Anna
Published: June 2024

El diseño tiene un impacto en la configuración de lo material, al diseñar objetos el diseñador coproduce experiencias de consumo y propone la materialidad que circula en los distintos sistemas de prácticas. En este libro se evidencia que cuando el diseño y las prácticas sociales se ponen en juego establecen una estructura relacional compleja, cambiante y multidimencional, y además, da cuenta de la configuración disciplinar del diseño en torno a su relación con el contexto y el usuario, así como sus implicaciones en la vida cotidiana, aclarando así los modos en que el diseño modifica el consumo, y puntualmente, cómo contribuye a sostener o no prácticas en escenarios de crisis social, económica y ambiental. 162 páginas
Peningkatan Penggunaan Aplikasi Primary Care Pada Unit Rekam Medis Dan Informasi Kesehatan Puskesmas Jalan Gedang
Authors: Ramadani Niska , Heltiani Nofri
Published: June 2024

Aplikasi Primary Care merupakan sebuah sistem informasi yang dirancang dan dikembangkan untuk melayani pasien pengguna fasilitas kesehatan (faskes) tingkat pertama. Sistem ini memberikan kemudahan untuk mengakses data ke server BPJS baik itu proses pendaftaran, penegakan diagnosa, terapi, hingga pelayanan laboratorium. Puskesmas Jalan Gedang sudah menggunakan aplikasi Primary-Care, namun penggunaan aplikasi Primary-Care belum digunakan secara maksimal seperti aplikasi primary care hanya digunakan untuk menginput data identitas sosial pasien, dan data rujukan sedangkan untuk data pemeriksaan dan pengkodingan diagnosa hanya ditulis pada berkas rekam medis, hal ini dikarenakan komputer yang bisa digunakan untuk pengolahan data hanya ada satu unit komputer. Sehingga membutuhkan waktu yang cukup lama untuk memverifikasi data kunjungan pasien serta proses pengklaiman setiap bulan. Kegiatan Pengabdian Masyarakat ini bertujuan untuk memberikan penyuluhan tentang manfaat penggunaan aplikasi primary care di Puskesmas Jalan Gedang. Penerapan aplikasi primary-care sangat bermanfaat dalam menunjang pelayanan yang diberikan kepada pasien, serta terlaksananya pelaporan kepada BPJS secara  terintegrasi dari setiap bagian diinstitusi pelayanan dasar sampai institusi pelayanan kesehatan rujukan. Dengan menggunakan aplikasi Primary Care dapat membuat pekerjaan menjadi lebih mudah, efisien, lebih cepat, praktis, efektif dalam memberikan pelayanan serta dapat meningkatkan produktivitas kinerja petugas, sedangkan dalam pelayanan keuntungan yang dapat kita peroleh dengan menggunakan aplikasi Primary-Care adalah alur pendaftaran pasien yang lebih praktis, data pasien yang terintegrasi, proses diagnose pasien lebih cepat, proses rujukan pasien lebih mudah.
Model P-IKADKA sebagai Solusi Mengembangkan Modul Ajar Apresiasi Dongeng di Sekolah Dasar
Authors: Anindya Arini , Apriliya Seni , Putri Agnestasia Ramadhani
Published: June 2024

This research was motivated by the unavailability of teaching modules that lead to appreciation learning and not using a special learning model for fairy tale appreciation. The aim of this research is to analyze the need for a fairy tale appreciation teaching module for Indonesian language subjects in class IV elementary school. The approach used in this research is a qualitative approach with descriptive methods. This research was conducted in the period 26 February - 1 March 2024 in two public elementary schools in Tasikmalaya City with research subjects namely two class IV educators and teaching module documents. The data collection techniques used were observation, document study and interviews. The data analysis technique used is the data analysis technique using the Miles and Huberman model in three stages, namely data reduction, data presentation, and drawing conclusions. The research results show that the fairy tale appreciation learning process is still not implemented optimally in an appreciative manner, because educators still have not planned learning optimally. Educators still use teaching modules provided by the government, so the learning model used does not use a learning model specifically for learning literary appreciation. Thus, there is no teaching module available that leads to learning to appreciate fairy tales in it. The implication is that it is necessary to develop an Indonesian language teaching module with fairy tale appreciation material that leads to appreciation learning using a learning model that is appropriate to literary appreciation learning, namely the P-IKADKA model with the syntax of introduction, introduction, connection, appreciation, discussion, comprehension and affirmation.
Transcatheter Arterial Chemo Infusion (TACI) for Squamous Cell Carcinoma of the Tongue: A Case Report
Authors: Poedjomartono Bagaswoto , Bangun Alan Anderson , Frinces Freshilla Sonia , Indrarto Erwin Yudhistira Yasanusaraharja , Faiz Ahmad
Published: June 2024

Introduction: Cancers of the lip and oral cavity, with the tongue being the most common site, accounted for more than 377,700 cases and more than 177,700 deaths worldwide in 2020. Ninety percent of these oral neoplasms are squamous cell carcinomas (SCC). The main treatments for oral cancers are surgery, radiotherapy, and chemotherapy, either combined or as stand-alone therapies. Transcatheter Arterial Chemo Infusion (TACI) is considered the definitive treatment for locoregionally advanced squamous cell carcinoma of the oral cavity, aiming to preserve function after surgery while maintaining or improving locoregional control and survival rates. This case report presents the qualitative result of TACI on SCC of the tongue. The aim of this case report is to demonstrate the potency of TACI as an alternative palliative therapy for SCC of the tongue. Case Presentation: A 37-year-old man with SCC of the tongue was diagnosed and treated at Dr. Sardjito General Hospital, Yogyakarta in 2021. The patient underwent TACI procedure and subsequent radiotherapy sessions subsequently. The therapeutic response was evaluated by observing the clinical morphology of the lesions. Conclusions: TACI is a minimally invasive technique used in the management of SCC. TACI has shown its potency as an efficient and effective alternative palliative therapy.
Pelatihan Teknik Penyusunan Presentasi Produk atau Ide Bisnis Untuk Siswa SMK Negeri 1 Sukawati
Authors: Iswari Ni Made Satvika
Published: June 2024

Kewirausahaan merupakan kompetensi penting dalam era globalisasi saat ini. Presentasi produk atau ide bisnis adalah platform untuk mengkomunikasikan visi dan ide bisnis ini dengan cara yang meyakinkan. Dengan memanfaatkan presentasi produk atau ide bisnis secara efektif, perusahaan dapat meningkatkan peluang kesuksesan, menghasilkan minat dari pelanggan dan mitra potensial. Dalam kegiatan pengabdian kepada masyarakat ini, telah dilakukan kegiatan pelatihan teknik penyusunan presentasi produk atau ide bisnis untuk siswa SMK Negeri 1 Sukawati. Tujuan dari pelaksanaan kegiatan ini adalah untuk mengembangkan kemampuan komunikasi siswa, meningkatkan kepercayaan diri dalam berbicara di depan umum, serta membekali teknik-teknik presentasi yang menarik dan persuasif. Metode pelaksanaan kegiatan terdiri dari analisis kebutuhan mitra, koordinasi pra pelaksanaan kegiatan, pelaksanaan kegiatan pelatihan, dan evaluasi. Pelatihan yang dilaksanakan telah memberikan pengetahuan praktis dan keterampilan yang diperlukan dalam memulai dan mengakselerasi bisnis, serta dapat membantu para siswa untuk memahami cara membuat presentasi yang efektif untuk produk atau ide bisnis.
Factors influencing late antenatal care of Muslim pregnant women: A predictive correlational study in Aceh, Indonesia
Authors: Fajarina Mira , Terathongkum Sangthong , Lininger Jiraporn
Published: June 2024

Background: Late antenatal care (ANC) has significant implications for maternal and infant morbidity and mortality among Muslim pregnant women in Indonesia. Existing literature has primarily focused on gestational weeks at the first ANC contact, with limited attention to the total number of ANC visits.
Objective: This study aimed to explore the factors predicting late antenatal care contact among Muslim pregnant women, including the gestational weeks of the first ANC contact and the total number of ANC visits in Aceh, Indonesia.
Methods: A predictive correlational study design was utilized. Eighty postpartum women who received late ANC were purposively sampled and included in the study. Data were collected in May 2023 using ANC knowledge, beliefs, and social support questionnaires. Statistical analyses included descriptive statistics, Spearman’s rank correlation, Chi-Square tests, and binary logistic regression with the enter method.
Results: Pregnant women residing farther from home to ANC services were more likely to have their first ANC contact after 20 weeks than those with a shorter distance (AOR = 1.06; 95% CI: 1.02-1.10; p = 0.007). Additionally, women with a history of multiple abortions were more inclined to have four or more ANC visits compared to those with fewer abortions (AOR = 6.78; 95% CI: 1.64-28.09; p = 0.008).
Conclusion: Distance from home to healthcare services emerged as a significant barrier to ANC contact, while a history of abortion appeared to motivate pregnant women to seek ANC more frequently. To address these issues effectively, nurses should consider implementing telemedicine services for ANC provision, integrating information on pregnancy complications to better support pregnant women in their care journey.
Blackness, Repetition, and Non-Philosophy
Authors: Paul Farley Anthony
Published: June 2024

This essay considers the spectacle of slavery that is death, and death only which continually persists as slavery-to-segregation-to-neosegregation or otherwise understood as a system of white-over-black. By observing the motionless movement of death perfecting itself (neither as life nor as historical time, progress, the human, or development), I argue that law makes death sovereign. The essay pursues this line of inquiry by considering a. capitalism as a system of spectacular relationships, a system of legal relationships, that places death atop everything and as a faith expressed in the gospel of legal method and its false promise of perpetual progress. And b. law as a structure analogous to the unconscious since it exists outside of time. In placing these two concerns together, it considers a sort of magical thinking of law—a make-believe realm in which rules appear to somehow govern themselves and an ‘us’ that seemingly masks over and absolves the system of white-over-black. Such banishment, whereby the system of white-over-black banished from the realm of the spectacle, is by that act repatriated to and given sovereignty over the world of the real, the world of historical time.
SPOR TURİZMİNİN İMKAN VE ETKİLERİ: TÜRKİYE ÖZELİNDE BİR DEĞERLENDİRME
Authors: Çavuş Muhammet Nimet
Published: June 2024

Spor turizmi kavramı, hem akademik bir çalışma alanı hem de bilinirliği giderek artan bir turizm ürünü olarak son yıllarda daha da ön plana çıkmıştır. Bu kapsamda çalışmada, Türkiye’de spor turizminin gelişimini, imkan ve etkileri açısından incelemek amaçlanmıştır. Araştırma kapsamında öncelikle spor turizmi kavramı, spor turizminin önemi ve etkileri açıklanmış, daha sonra Türkiye’de spor turizmine ilişkin bir değerlendirme yapılmıştır. Türkiye her mevsim spor yapmaya uygun iklim koşullarına sahip olup dağ, nehir, kanyon, mağara vb. zengin coğrafi koşulların yanı sıra alternatif spor faaliyetlerine uygun mekânlara da sahiptir. Bu bağlamda Türkiye’de gerek kamu gerek özel sektör tarafından son yıllarda yapılan büyük tesis yatırımları spor tesislerinin yetersizliği sorununu çözmede önemli bir adım olurken bu tesislerin içerisine ya da çevresine yapılan konaklama tesisleri de hem bölge halkına hem de ülkeye gelir kaynağı olmuştur. Literatür incelendiğinde Türkiye’de spor turizminin gelişmesinde Türkiye’nin ev sahipliği yaptığı uluslararası spor organizasyonlarının yanı sıra Türkiye’de doğa ve macera turizmi kapsamında gerçekleştirilen sportif faaliyetlerin de etkili olduğu belirlenmiştir. Türkiye iklimi, doğası ve konumu gereği doğa ve macera turizmi kapsamında gerçekleştirilen dağcılık, rafting, rüzgar sörfü, kayak, golf, dalış gibi sportif faaliyetler için uygun bir ülke olduğunu söylemek mümkündür. Sonuç olarak, spor turizmi Türkiye’de her yıl büyüyerek tanınır hale gelen bir turizm türüdür. Hem turizm hem spor tüketicileri için tüketici eğilimleri dikkate alınarak, spor ve turizm sektörleri arasındaki işbirliği sağlanmalıdır. Turizmin yılın her ayı faaliyet gösteren bir sektör olabilmesi için çeşitliliğin ve kaynakların arttırılması gerekmektedir. Spor turizmi kapsamında kayak, golf, rüzgar sörfü, dalış, rafting, kano gibi çok önemli sektör değerlerine sahip olan Türkiye, bu alanlara hizmet edecek altyapıyı en iyi şekilde geliştirmelidir.
PROFESYONEL VOLEYBOLCULARIN İMGELEME VE BAŞARI MOTİVASYON DÜZEYLERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: Alemdağ Serdar , Ünlü Ünal
Published: June 2024

Günümüzde profesyonel sporcular müsabakalar için hazırlık döneminde ve müsabakalardan üst düzeyde verim alma sürecinde imgeleme becerilerini kullanmaktadır. Müsabakalar esnasında oluşabilecek engellerin üstesinden gelmek ve müsabakalar esnasında performanslarını üst düzeyde tutabilmek için başarı motivasyonu becerilerini kullanmaları gerekmektedir. Bu araştırmada profesyonel voleybolcuların imgeleme ve başarı motivasyon düzeyleri arasındaki ilişkinin cinsiyet değişkenine göre incelenmesi amaçlanmıştır. Araştırmanın örneklem grubunu 2021-2022 sezonunda Türkiye Voleybol Federasyonu Liglerinde mücadele eden 372 kadın, 312 erkek olarak toplam 684 voleybol sporcusu oluşturmaktadır. "Kişisel Bilgi Formu", “Spora Özgü Başarı Motivasyonu Ölçeği (SÖBMÖ)" ve “Sporda İmgeleme Envanteri (SİE)” veri toplama araçları olarak kullanılmıştır. Nicel araştırma yaklaşımlarından ilişkisel tarama yönteminin kullanıldığı araştırmada, veri analizi SPSS istatistik paket programı aracılığıyla gerçekleştirilmiştir. Verilerin analizinde frekans ve yüzde, t testi ve Korelasyon analizlerinden yararlanılmıştır. Araştırmanın sonucunda, spora Özgü Başarı Motivasyonu ve Sporda İmgeleme Ölçeklerinin bazı boyutlarında pozitif yönde anlamlı bir ilişki bulunmuştur. Sonuç olarak sporda imgelemenin, profesyonel voleybolcuların başarı motivasyonlarını önemli ölçüde artırdığını söylemek mümkündür.
Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties
Authors: Saban Güler Meryem , Yıldıran Hilal
Published: June 2024

Nobiletin is a polymethoxylated flavone found in citrus peels. Thanks to its chemical structure and biological activities, nobiletin has been shown to have a positive effect on many diseases. In recent years, there has been a growing interest in research focusing on the impact of nobiletin and its metabolites on different cancer types. Nobiletin exhibits anticancer properties by impeding the proliferation of cancer cells, disrupting the cancer cell cycle, facilitating apoptosis, and regulating signaling pathways implicated in cancer development. In addition, studies have shown that its use with chemotherapeutic agents inhibits multi-drug resistance. This review aims to evaluate the metabolic properties of nobiletin and its possible effects on cancer.
Monkey menace in Nepal: An analysis and proposed solutions
Authors:   Organic Agriculture Program, Madan Bhandari University of Science and Technology, Chitlang, Thaha Municipality-9, Nepal, Rai Sushil , Rai Rameshwar ,   Organic Agriculture Program, Madan Bhandari University of Science and Technology, Chitlang, Thaha Municipality-9, Nepal
Published: June 2024

Monkey menace is a prevalent issue in South Asia and Southeast Asia, where Rhesus macaques are considered pests of major field crops. In Nepal, factors such as monoculture cropping patterns, forest fragmentation, degradation of natural habitats, and changing agricultural practices contribute to increased monkey menace and human-macaque conflict. Factors such as cropping season, food resource distribution, crop variety, wild food availability, and distance from forests and farms influence the frequency and intensity of crop raiding. This study introduced non-human primates, their status, and availability in Nepal, and analyzed different crops raided by monkeys along the Buddhi Gandaki River, frequency and crop raiding season of monkeys in Jhor Mahankal and Goldhunga and suggested some solution measures for the monkey menace in Nepal. Maize was the most raided crop, while pumpkin was the least. The total percentage of crops raided was 24.62%, with an average crop loss of 29.24%. Crop raiding was most prevalent during the spring season (45%), followed by the rainy season (39%), and least prevalent during the winter season (16%). Rhesus macaques refrained from raiding crops with bitter or spicy flavors, such as turmeric, bitter gourd, chili, ginger, and mustard. The suggested control measures need to be followed to mitigate the monkey menace and manage the human-wildlife conflict.
Simulation of FES on the forearm with muscle-specific activation resolution
Authors: Baier Johanna , Selkmann Sascha , Bender Beate
Published: June 2024

Introduction

Functional electrical stimulation (FES) is an established method of supporting neurological rehabilitation. However, particularly on the forearm, it still cannot elicit selective muscle activations that form the basis of complex hand movements. Current research approaches in the context of selective muscle activation often attempt to enable targeted stimulation by increasing the number of electrodes and combining them in electrode arrays. In order to determine the best stimulation positions and settings, manual or semi-automated algorithms are used. This approach is limited due to experimental limitations. The supportive use of simulation studies is well-established, but existing simulation models are not suitable for analyses of selective muscle activation due to missing or arbitrarily arranged innervation zones.

Methods

This study introduces a new modeling method to design a person-specific digital twin that enables the prediction of muscle activations during FES on the forearm. The designed individual model consists of three parts: an anatomically based 3D volume conductor, a muscle-specific nerve fiber arrangement in various regions of interest (ROIs), and a standard nerve model. All processes were embedded in scripts or macros to enable automated changes to the model and the simulation setup.

Results

The experimental evaluation of simulated strength–duration diagrams showed good coincidence. The relative differences of the simulated amplitudes to the mean amplitude of the four experiments were in the same range as the inter-experimental differences, with mean values between 0.005 and 0.045. Based on these results, muscle-specific activation thresholds were determined and integrated into the simulation process. With this modification, simulated force-intensity curves showed good agreement with additionally measured curves.

Discussion

The results show that the model is suitable for simulating realistic muscle-specific activations. Since complex hand movements are physiologically composed of individual, selective muscle activations, it can be assumed that the model is also suitable for simulating these movements. Therefore, this study presents a new and very promising approach for developing new applications and products in the context of the rehabilitation of sensorimotor disorders.
High-throughput drug screening to investigate blood-brain barrier permeability in vitro with a focus on breast cancer chemotherapeutic agents
Authors: Curtaz Carolin J. , Wucherpfennig Sophia , Al-Masnaea Emad , Herbert Saskia-Laureen , Wöckel Achim , Meybohm Patrick , Burek Malgorzata
Published: June 2024

Therapy of cerebral diseases such as brain metastatic breast cancer is still challenging. Due to the blood-brain barrier (BBB), a tight barrier that protects the brain and prevents the passage of many drugs, therapeutically sufficient drug concentrations in the brain are often not achieved. Therefore, methods and drugs to manipulate the BBB permeability are required. Here we used high-throughput screening (HTS) to identify chemicals that may increase BBB permeability. Human BBB in vitro model derived from hematopoietic CD34+ stem cells (differentiated to brain-like endothelial cells, BLECs) was used. BLECs were seeded on 96-well plates coated with biotinylated gelatin, treated with respective chemicals for 24 h followed by addition of FITC-avidin for permeability estimation. Selected substances were further tested in vitro on BLECs. Cell viability, gene and protein expression were measured using CellTiter-Glo®, qPCR and Western blot, respectively. From 1,278 compounds, we identified 175 substances that cause at least a 50 percent increase in BBB permeability. Two substances from the substance classes used in breast cancer therapy, GW2974 (tyrosine kinase inhibitor) and 4-amino-1,8-naphthalimide (ANI) (PARP inhibitor), were analyzed in more detail. ANI was nontoxic to BLECs, while GW2974 decreased or increased viability depending on the concentration used. Both compounds significantly increased BBB permeability and altered protein and mRNA expression in BLECs. Influencing the BBB permeability in patients with brain metastases could increase the response rate to systemic therapy. Using HTS, we were able to accurately and quickly identify compounds that increase BBB permeability and show that using this type of screening method can be applied to endothelial paracellular permeability testing.
Agents of change: integration of neuropedagogy in pre-service teacher education
Authors: Shvarts-Serebro Inna , Ben-Yehudah Gal , Elgavi-Hershler Orit , Grobgeld Etty , Katzof Ayelet , Luzzatto Efrat , Shalom Maya , Zohar-Harel Tamar
Published: June 2024

Neuropedagogy, an interdisciplinary field at the nexus of neuroscience, psychology, and education, seeks to enhance teaching and learning processes. This paper advocates for the integration of neuropedagogical principles into teacher training, underscoring the pivotal role educators play in influencing students’ brain development. Incorporating neuroscientific knowledge in teaching can optimize educational outcomes. We explore key neuropedagogical principles, and highlight global developments in neuropedagogy. Three strategic avenues for integrating neuropedagogy in teacher training are proposed: promoting innovative teaching practices in teacher training, encouraging neuropedagogical research, and explicitly teaching neuroscientific knowledge to pre-service teachers. Our conclusion emphasizes the invaluable contribution of neuropedagogy to education and calls for its inclusion in pre-service teacher training.
Evaluation of field epidemiology training programs: a scoping review
Authors: Al Nsour Mohannad , Khasawneh Ghena , Khader Yousef , Bashier Haitham
Published: June 2024

Objectives

Field Epidemiology Training Programs (FETPs) are competency-based training programs that play a critical role in strengthening global health security and enhancing the epidemiological capabilities of public health professionals. This scoping review examined available published literature on the evaluations of FETPs globally.

Methods

A literature review was conducted to evaluate FETPs globally. Keywords specific to the evaluation of FETPs were utilized to search the PubMed, Scopus, and Web Science databases. After applying the inclusion and exclusion criteria, 12 relevant studies from an initial pool of 60 were included in this study. Data extraction included key details, and a qualitative synthesis organized diverse findings using a narrative approach to draw appropriate conclusions and generate recommendations.

Results

The review covered findings from 12 studies covering all three FETP modalities and spanning countries in various regions. Evaluations explored gained skills, engagement in FETP activities, and improvements in field epidemiological functions. Gained skills and knowledge, engagement in FETP activities, and improvements in field epidemiological functions were evident, with specific expectations for each FETP tier. Positive outcomes were consistent across studies, revealing improvements in surveillance activities, outbreak response, data management, and other system functions.

Conclusion

This review confirmed the positive impact of FETPs on trainees and graduates, which emphasized competency enhancements across different modalities. Various strategies are recommended to improve the evaluation of FETPs. For effective evaluation, it is necessary to develop robust evaluation tools and establish standardized metrics to compare FETPs across regions or countries.
Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates
Authors: Roh Juhye , Hwang Jeong Ho , Park Sangkeun , Lee Haneulnari , Park Eun Mi , Lee Hye Won , Lee Ju Young , Shim Joohyun , Choi Kimyung , Kang Hee Jung
Published: June 2024

Introduction

Decreasing rates of blood donation and close margins between blood supply and demand pose challenges in healthcare. Genetically engineered pig red blood cells (pRBCs) have been explored as alternatives to human RBCs for transfusion, and triple-gene knockout (TKO) modification improves the compatibility of pRBCs with human blood in vitro. In this study, we assessed the efficacy and risks of transfusing wild-type (WT)- and TKO-pRBCs into nonhuman primates (NHPs).

Methods

Blood from O-type WT and TKO pigs was processed to produce pRBCs for transfusion, which were transfused or not into NHPs (n=4 per group: WT, TKO, and control) after 25% total blood volume withdrawal: their biological responses were compared. Hematological, biochemical, and immunological parameters were measured before, immediately after, and at intervals following transfusion. Two months later, a second transfusion was performed in three NHPs of the transfusion group.

Results

Transfusion of both WT- and TKO-pRBCs significantly improved RBC counts, hematocrit, and hemoglobin levels up to the first day post-transfusion, compared to the controls. The transfusion groups showed instant complement activation and rapid elicitation of anti-pig antibodies, as well as elevated liver enzyme and bilirubin levels post-transfusion. Despite the higher agglutination titers with WT-pRBCs in the pre-transfusion crossmatch, the differences between the WT and TKO groups were not remarkable except for less impairment of liver function in the TKO group. After the second transfusion, more pronounced adverse responses without any hematological gain were observed.

Conclusions

WT- and TKO-pRBC transfusions effectively increased hematologic parameters on the first day, with rapid clearance from circulation thereafter. However, pRBC transfusion triggers strong antibody responses, limiting the benefits of the pRBC transfusion and increasing the risk of adverse reactions.
Showcasing the Saudi e-referral system experience: the epidemiology and pattern of referrals utilising nationwide secondary data
Authors: Aljerian Nawfal A. , Alharbi Abdullah A. , AlOmar Reem S. , Binhotan Meshary S. , Alghamdi Hani A. , Arafat Mohammed S. , Aldhabib Abdulrahman , Alabdulaali Mohammed K.
Published: June 2024

Introduction

Referrals are an integral part of any healthcare system. In the Kingdom of Saudi Arabia (KSA) an electronic referral (e-referral) system known as the Saudi Medical Appointments and Referrals Centre (SMARC) began formally functioning in 2019. This study aims to showcase the Saudi experience of the e-referral system and explore the epidemiology of referrals nationally.

Methods

This retrospective descriptive study utilised secondary collected data between 2020 and 2021 from the SMARC system. Cross tabulations with significance testing and colour-coded maps were used to highlight the patterns across all regions.

Results

The study analysed over 600,000 referral requests. The mean age of patients was 40.70 ± 24.66 years. Males had a higher number of referrals (55.43%). Referrals in 2021 were higher than those in 2020 (56.21%). Both the Autumn and Winter seasons had the highest number of referrals (27.09% and 27.43%, respectively). The Surgical specialty followed by Medicine had the highest referrals (26.07% and 22.27%, respectively). Life-saving referrals in the Central region were more than double those in other regions (14.56%). Emergency referrals were also highest in the Southern regions (44.06%). The Central and Eastern regions had higher referrals due to unavailable sub-speciality (68.86% and 67.93%, respectively). The Southern regions had higher referrals due to both unavailable machine and unavailable beds (18.44% and 6.24%, respectively).

Conclusion

This study shows a unique system in which referrals are between secondary, tertiary, and specialised care. It also highlights areas of improvement for equitable resource allocation and specialised care in slightly problematic areas as well as the use of population density in future planning.
Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety
Authors: Fu Xin , Tasker Jeffrey G.
Published: June 2024

The basolateral amygdala plays pivotal roles in the regulation of fear and anxiety and these processes are profoundly modulated by different neuromodulatory systems that are recruited during emotional arousal. Recent studies suggest activities of BLA interneurons and inhibitory synaptic transmission in BLA principal cells are regulated by neuromodulators to influence the output and oscillatory network states of the BLA, and ultimately the behavioral expression of fear and anxiety. In this review, we first summarize a cellular mechanism of stress-induced anxiogenesis mediated by the interaction of glucocorticoid and endocannabinoid signaling at inhibitory synapses in the BLA. Then we discuss cell type-specific activity patterns induced by neuromodulators converging on the Gq signaling pathway in BLA perisomatic parvalbumin-expressing (PV) and cholecystokinin-expressing (CCK) basket cells and their effects on BLA network oscillations and fear learning.
Cognitive functioning in patients with neuro-PASC: the role of fatigue, mood, and hospitalization status
Authors: Cahan Joshua , Finley John-Christopher A. , Cotton Erica , Orban Zachary S. , Jimenez Millenia , Weintraub Sandra , Sorets Tali , Koralnik Igor J.
Published: June 2024

This study sought to characterize cognitive functioning in patients with neurological post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) and investigate the association of subjective and objective functioning along with other relevant factors with prior hospitalization for COVID-19. Participants were 106 adult outpatients with Neuro-PASC referred for abbreviated neuropsychological assessment after scoring worse than one standard deviation below the mean on cognitive screening. Of these patients, 23 had been hospitalized and 83 had not been hospitalized for COVID-19. Subjective cognitive impairment was evaluated with the self-report cognition subscale from the Patient-Reported Outcome Measurement Information System. Objective cognitive performance was assessed using a composite score derived from multiple standardized cognitive measures. Other relevant factors, including fatigue and depression/mood symptoms, were assessed via the Patient-Reported Outcome Measurement Information System. Subjective cognitive impairment measures exceeded the minimal difficulties noted on objective tests and were associated with depression/mood symptoms as well as fatigue. However, fatigue independently explained the most variance (17.51%) in patients’ subjective cognitive ratings. When adjusting for fatigue and time since onset of COVID-19 symptoms, neither objective nor subjective impairment were associated with prior hospitalization for COVID-19. Findings suggest that abbreviated neuropsychological assessment may not reveal objective difficulties beyond initial cognitive screening in patients with Neuro-PASC. However, subjective cognitive concerns may persist irrespective of hospitalization status, and are likely influenced by fatigue and depression/mood symptoms. The impact of concomitant management of fatigue and mood in patients with Neuro-PASC who report cognitive concerns deserve further study.
The “appearing” and “disappearing” ascites in the treatment of colorectal cancer: a case report
Authors: Cui Hong-Ming , Shu Xin-Peng , Wei Zheng-Qiang , Wu Xing-Ye
Published: June 2024

Background

Colorectal cancer (CRC) is one of the most common cancers worldwide. In the treatment of patients with CRC, oxaliplatin plays a pivotal role, with moderate side effects. Neurotoxicity, myelosuppression, ototoxicity, delayed hypersensitivity reactions, and rhabdomyolysis induced by oxaliplatin have been reported individually. However, the occurrence of oxaliplatin-induced ascites has not been reported previously. The objectives of this case report were to elaborate on the rare occurrence of ascites in a patient with CRC after oxaliplatin therapy and to explore its characteristics and causes.

Case description

We report on a case of upper rectal cancer seen in a 65-year-old man who underwent robotic-assisted laparoscopic anterior rectal resection. The patient developed ascites during postoperative adjuvant therapy with oxaliplatin and capecitabine. We ruled out tumor recurrence by laparoscopy, intraoperative biopsy, and biochemistry of the ascites. The patient did not experience a recurrence of ascites after discontinuation of chemotherapy.

Conclusion

This case suggests that chemotherapy with oxaliplatin might cause ascites. The mechanism of the oxaliplatin-induced liver injury was further discussed, which might have been the cause of ascite formation. When patients with CRC who underwent chemotherapy with oxaliplatin develop ascites, surgeons should actively determine whether this is a side effect of chemotherapy or is due to tumor recurrence in order to avoid unnecessary surgery.
A combination of risk stratification systems for thyroid nodules and cervical lymph nodes may improve the diagnosis and management of thyroid nodules
Authors: Xu Cong-Ying , Yu Jing , Cui Yi-Yang , Huang Yuan-Jing , Fu Chao , Cui Ke-Fei
Published: June 2024

Introduction

To assess the performance of the European Thyroid Association Thyroid Imaging and Reporting Data System (EU-TIRADS) and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS), which combine risk stratification systems for thyroid nodules (TN-RSS) and cervical lymph nodes (LN-RSS) in diagnosing malignant and metastatic thyroid cancer in a single referral center.

Methods

We retrospectively analyzed 2,055 consecutive patients who underwent thyroidectomy or fine-needle aspiration (FNA) from January 2021 to December 2022. TNs and LNs were categorized according to the ultrasonography (US) features of EU-TIRADS and K-TIRADS, respectively. The diagnostic performance and postponed malignancy rate (PMR) were compared with those of EU-TIRADS and K-TIRADS. PMR was defined as the number of patients with malignant nodules not recommended for biopsy among patients with cervical LN metastasis.

Results

According to the EU-TIRADS and K-TIRADS, for TN-RSS alone, there were no significant differences in sensitivity, specificity, accuracy, unnecessary FNA rate (UFR), missed malignancy rate (MMR), and PMR between the two TIRADSs (29.0% vs. 28.8%, 50.5% vs. 51.1%, 32.3% vs. 32.2%, 23.6% vs. 23.5%, 88.6% vs. 88.5%, and 54.2% vs. 54.5%, P > 0.05 for all). Combining the LN-RSS increased the diagnostic accuracy (42.7% vs. 32.3% in EU-TIRADS; 38.8% vs. 32.2% in K-TIRADS) and decreased the PMR (54.2% vs. 33.9% in EU-TIRADS; 54.5% vs. 39.3% in K-TIRADS). EU-TIRADS had higher sensitivity and accuracy and lower PMR than K-TIRADS (41.3% vs. 36.7%, 42.7% vs. 38.8%,33.9% vs. 39.3%, P < 0.05 for all).

Conclusions

A combination of TN-RSS and LN-RSS for the management of thyroid nodules may be associated with a reduction in PMR, with enhanced sensitivity and accuracy for thyroid cancers in EU-TIRADS and K-TIRADS. These results may offer a new direction for the detection of aggressive thyroid cancers.