bluuebunny/crossref_metadata_2025 huggingface dataset:
PENDAMPINGAN PELAKSANAAN RETENSI REKAM MEDIS DI PUSKESMAS GEDONGTENGEN YOGYAKARTA
Authors: Rohman Hendra , Wahyuningsih Wiji , Nurrochman Alwhan , Saputra Rangga Pramudya
Published: May 2023

Puskesmas Gedongtengen belum pernah melakukan penyusutan berkas rekam medis, akibatnya ruang penyimpanan terjadi penumpukan berkas, menjadi sempit dan pencarian menjadi sulit dan lama. Ketersediaan berkas membantu kualitas mutu pelayanan rekam medis. Kegiatan pengabdian dilakukan melalui konsultasi, pendampingan hingga implementasi pengelolaan berkas rekam medis aktif, inaktif, sistem penyimpanan dan rencana pemusnahan. Puskesmas memiliki sistem penyimpanan rekam medis aktif dan inaktif, tetapi belum mempunyai jadwal retensi. Jumlah entry data rekam medis inaktif yang dilakukan pada bulan Maret 2022 yaitu 7.301 berkas dengan rata-rata kegiatan retensi 487 berkas rekam medis inaktif setiap harinya. Pada bulan April 2022 yaitu 8.574 berkas dengan rata-rata kegiatan retensi 715 berkas rekam medis inaktif setiap harinya. Pada berkas rekam medis yang telah dilakukan entry data masih ditemukan berkas rekam medis aktif karena beberapa petugas memilah berkas untuk dipindahkan ke penyimpanan inaktif belum memiliki kualifikasi sebagai seorang perekam medis. Entry data menggunakan media google drive sebagai alat bantu yang dilakukan pada kegiatan ini sangat efektif dan efisien karena setiap orang dapat mengakses langsung secara bersamaan, data yang dikumpulkan dapat terintegrasi, realtime dan dapat dipantau lebih mudah. Rencana pemusnahan dilakukan pada berkas kunjungan terakhir tahun 2016 sesuai dengan Perwal, untuk tahun 2017 hingga 2019 masih disimpan untuk periode pemusnahan berikutnya.
The Plight of Athletic Training Graduates in a Third World Country: An Obscure and Unregulated Profession in Jamaica
Authors: Der Rowe Van
Published: May 2023

Background: Sports treatment and rehabilitation in Jamaica appears to be a costly struggle for athletes of all ages, with very few facilities and specialists on the island. However, the introduction of the athletic training (AT) profession can bridge the gap in sports treatment and rehabilitation by creating a solid foundation for athletes, especially at the high school level. After 12 years of establishing the course of study in Jamaica, athletic trainers (ATs) are still not recognized and are unable to practice.
Purpose: The purpose of this study was to highlight the aspirations of the athletic training profession in Jamaica.
Methods: The study was conducted using an explanatory case study design that used an open-ended survey to collect data from AT graduates. A total of 20 participants were selected using a combined sampling method that utilized purposive and snowball sampling techniques. Google forms were used to create the open-ended questions and a content analysis method that utilized multi-analyst coding was used to establish relevant themes and categories from the responses.
Results: The results of the study indicated that graduates are fnding it extremely difcult to get jobs as athletic trainers, due to the lack of awareness, promotion, and ambiguity of AT in Jamaica. Despite the challenges, graduates believed that a national AT association is crucial for seeking licensure and promoting awareness of the profession in Jamaica.
Conclusion: If recognized, ATs can signifcantly help to boost sports treatment in Jamaica and contribute to greater sporting performances.
Keywords: allied health professionals, athletic trainers, developing profession.
Study of Wind Resources in the Territory of the Kyrgyz Republic
Authors: Matisakov T.
Published: May 2023

The article analyzes the feasibility of using renewable energy sources in comparison with other types of fuel. It was noted that the time has come to consider renewable energy sources as conventional energy sources. Renewable energy sources, including the use of wind resources, were explored in the case of the Kyrgyz Republic. Wind resources of the Kyrgyz Republic were studied by regions. When using wind resources, depending on the wind speed in the region, the possibilities of using them for water pumps and generating electricity for agriculture were studied.
Enrichment of Baked Goods From Wheat Flour of the Highest Grade With Coffee Husks
Authors: Komissarova A. , Moyseak M.
Published: May 2023

This article presents a variant of the manufacture of dietary and preventive baked goods enriched with dietary fiber by adding coffee husks, a by-product of coffee production, to the recipe. In the course of the work, the influence of various volumes of introduced raw materials, in the amount of 3 and 6% of the total mass of flour, on the physicochemical and organoleptic quality indicators of the finished product was studied, a comparative analysis of the obtained bread samples was carried out, and the optimal dosage of coffee shells that did not reduce quality properties of baked goods. Thanks to this method of preparation, it becomes possible to create a product not only rich in fiber, but also with a valuable chemical composition, with a high level of potassium and vitamins. Such bread will be an excellent addition not only to the daily diet, but also to the menu of dietary nutrition necessary for a group of various diseases, ranging from metabolic disorders and obesity to cardiovascular pathologies, as it will close the body’s daily need for dietary fiber. In addition, it should be noted that the problem of environmental pollution with coffee production waste is acute for society. As a rule, secondary raw materials obtained during the processing of coffee are subjected to recycling or incineration. The method of recycling coffee shells proposed in the article allows not only to obtain a new healthy food product and expand the existing range of baked goods, but also significantly reduce the amount of waste remaining from the coffee bean processing process, which also entails financial benefits.
Dwi Monika Ningrum THE ROLE OF A PHARMACIST IN APPLYING THE STANDARD OF PHARMACEUTICAL CARE IN PHARMACY AT WEST LOMBOK
Authors: Dwi Monika Ningrum
Published: May 2023

Pharmaceutical care is a direct and responsible service to patients related to pharmaceutical preparations with the aim of achieving definite results to improve the quality of life. The standards of Pharmaceutical care in pharmacies are designed to serve as guidelines for pharmacist practice in carrying out the profession, to protect the public from unprofessional services and to protect the profession in carrying out pharmaceutical practices. This study aims to describe the implementation of pharmaceutical service standards in pharmacies in West Lombok Regency. This research is a non-experimental qualitative descriptive research with cross sectional data collection with a total of 40 pharmacies in Lombok Barat. The collection data was carried out using questionnaire sheets to respondents who were willing. The results obtained in this study include the management standards of pharmaceutical supplies by pharmacists together with pharmacist assistant with a percentage of 35.4%, clinical pharmacy service standards carried out by pharmacists with a percentage of 38%, and quality evaluation implementation. service in the pharmacy is carried out by pharmacists by 80%. The conclusion obtained in this study is that the role of pharmacists is very influential on the success of services, especially in clinical pharmacy services, namely in drug information services, monitoring drug therapy, and monitoring drug side effects which really require the role of a pharmacist.
KANKER LEHER RAHIM (CANCER CERVIX) SEBAGAI PEMBUNUH WANITA TERBANYAK DI NEGARA BERKEMBANG
Authors: Wulandari Dewi Susilawati
Published: May 2023

Di seluruh dunia, kanker serviks sebagian besar terdeteksi pada stadium akhir, sehingga umumnya disebut penyakit bisu. Serviks uterus adalah bagian terendah dari rahim wanita. Sebagian besar terus terletak di panggul, tetapi bagian dari serviks terletak di vagina, di mana ia menghubungkan rahim dengan vagina. Kanker serviks terjadi ketika sel-sel serviks berubah dengan cara yang mengarah pada pertumbuhan abnormal dan invasi jaringan atau organ tubuh lainnya. Seperti semua kanker, kanker leher rahim jauh lebih mungkin untuk disembuhkan jika terdeteksi dini dan segera diobati. Salah satu fitur kunci dari kanker serviks adalah perkembangannya yang lambat dari jaringan serviks yang normal, menjadi perubahan prakanker (atau displastik) dalam jaringan, untuk kanker invasif. Kemajuan yang lambat melalui berbagai perubahan prekanker sangat penting karena memberikan peluang untuk pencegahan dan deteksi dini serta pengobatan. Kanker invasif berarti kanker mempengaruhi jaringan serviks yang lebih dalam dan mungkin telah menyebar ke bagian tubuh lainnya. Penyebaran ini disebut metastasis. Kanker serviks tidak selalu menyebar, tetapi kanker yang paling sering menyebar ke paru-paru, hati, kandung kemih, vagina, dan / atau dubur. Kanker invasif dengan cara ini bisa menyebabkan kematian. Tinjauan literatur ini dimaksudkan untuk meningkatkan pemahaman tentang kanker serviks yang diharapkan berdampak pada peningkatan layanan kesehatan khususnya peningkatan tingkat pengetahuan tentang kanker serviks dan pencegahannya pada tahap awal untuk mengurangi kejadian kanker serviks dan kematian karena kanker serviks, khususnya di Indonesia.
EKSTRAK BUNGA CENGKEH SEBAGAI INSEKTISIDA TERHADAP MORTALITAS NYAMUK AEDES AEGYPTI METODE SEMPROT
Authors: Ariwidiani DRS IWAYAN GETAS,M.Sc , Ariwidhiani  , Erna Kristinawati
Published: May 2023

Peningkatan kasus DBD di Indonesia pada tahun 2016 sebanyak 204.171 kasus dengan jumlah kematian sebanyak 1.598 orang. Berdasarkan data profil kesehatan Indonesia, telah terjadi peningkatan kasus DBD di setiap tahunnya. Peningkatan angka kesakitan DBD juga terjadi di NTB pada tahun 2016 yaitu sebesar 52,80 per 100.000 penduduk. Pemanfaatan bunga cengkeh sebagai bahan insektisida alami dapat menjadi alternatif yang lebih ramah lingkungan sehingga dapat menekan dampak negatif dari penggunaan insektisida kimia. Tujuan dalam penelitian ini adalah untuk menganalisis potensi ekstrak bunga cengkeh (Syzygium aromaticum) sebagai insektisida terhadap nyamuk Aedes aegypti dengan metode semprot.  Penelitian ini merupakan penelitian eksperimental dengan post-test only controlled group design. Perlakuan dilakukan dalam 5 konsentrasi yaitu 5%, 10%, 15%, 20% dan 25%. Data yang diperoleh dianalisis secara statistic menggunakan uji Chi Square dan analisis probit. Berdasarkan hasil analisis, ekstrak bunga cengkeh (Syzygium aromaticum) berpotensi sebagai insektisida terhadap nyamuk Aedes aegypti dengan nilai signifikan 0.000 (p < 0.05) dengan konsentrasi LC50 diperoleh sebesar 3,434% dan LC90 sebesar 22,070%.
PENGARUH PEMBERIAN SUPLEMEN IKAN GABUS PADA STATUS NEUROLOGIS PASIEN STROKE ISKEMIK DI RUMAH SAKIT UMUM DAERAH PATUH PATUT PATJU
Authors: Ningrum Dwi Monika , MS Eka Septiani
Published: May 2023

Stroke is the leading cause of death and disability in a world that requires treatment and care in the long term. Many factors that influence the outcome and the level of worsening after ischemic stroke include hypoalbumin which is one of the factors affecting the outcome of stroke. This study to determine the effect of supplementation of Snakehead fish on neurological improvement ischemic stroke patients at Patuh Patut Patju hospital.

This study included quasi experimental research with Sparate Samples Pretest-Posttest design, Pre treatment ischemic stroke patients who have not given supplements of Snakehead fish (H1) and post treatment of ischemic stroke patients who have been given supplement Snakehead fish dose 3 times a day for 14 day (H14). Clinical outcome in grades of serum albumin levels, NIHSS and Barthel index. Analysis outcome with SPSS Shapiro wilk test,  Wilcoxon signed test , and Mann whitney testOutcome  post treatment decrease NIHSS score (p = 0,000, <0,05), increased Barthel index score (p = 0,000, <0,05), increased serum albumin level (p = 0.000, <0,05). Snakehead fish supplement can decrease NIHSS score, increase barthel index score and serum albumin level post given for 14 day.
PENGARUH EDUKASI KESEHATAN TENTANG HYGIENE KEWANITAAN TERHADAP PERILAKU REMAJA PUTRI DALAM MENCEGAH KEPUTIHAN DI SMPN 27 KOTA BEKASI TAHUN 2021
Authors: Nopita Dwi Novitasari , Anni Suciawati  , Rukmaini
Published: May 2023

Masa remaja adalah  masa transisi dimana terdapat banyak perubahan, dan terancam masalah salah satunya adalah keputihan yang membutuhkan pertimbangan khusus. Prevalansi data keputihan di wilayah provinsi Jawa Barat yang mengalami keputihan adalah sebesar 27,60%, dan dilihat dari sensus penduduk di Bekasi pada tahun 2014 jumlah remaja mencapai 318.864 jiwa dan yang mengalami keputihan adalah sebesar 29,48% dari populasi absolut. Sehingga dibutuhkan edukasi kesehatan agar remaja putri mengetahui perilaku mencegah keputihan yang baik dan benar. Dalam penelitian ini bertujuan untuk mengetahui Pengaruh Edukasi Kesehatan Tentang Hygiene Kewanitaan Terhadap Perilaku Remaja Putri dalam Mencegah Keputihan. Desain penelitian menggunakan  pre-experiment design dengan rancangan one group pretest and posttest. Sampel berjumlah 30 responden dengan Pengambilan sampel menggunakan purposive sampling, Instrumen penelitian adalah Angket (kuesioner). Uji statistik adalah parametric dengan menggunakan uji Paired Samples T-Test, Hasil penelitian menunjukkan bahwa rata-rata perilaku remaja putri sebelum diberikan edukasi kesehatan dengan skor17,67, dan setelah diberikan edukasi kesehatan dengan skor 27,43, dan ada pengaruh  Edukasi Kesehatan Tentang Hygiene Kewanitaan Terhadap Perilaku Remaja Putri dalam Mencegah Keputihan dengan hasil p : 0,000 <0,05. Disimpulkan bahwa Edukasi kesehatan mampu meningkatkan Perilaku remaja putri dalam mencegah keputihan dengan demikian diharapkan remaja putri dapat menerapkan pengetahuan yang telah didapatkan mengenai Hygiene kewanitaan dalam kehidupan sehari-hari untuk menjaga kesehatan organ  reproduksi.

 

Kata kunci : Edukasi Kesehatan, Kesehatan Reproduksi, hygiene kewanitaan, Perilaku, dan Remaja
ANALYSIS OF ANXIETY LEVEL OF PREMENOPAUSE IN KARAJAN BARAT VILLAGE OF CIKAMPEK BARAT DISTRICT OF KARAWANG REGENCY IN 2021
Authors: Irmayanti Irmayanti , Anni Suciawati  , Rukmaini
Published: May 2023

Development and growth in the human body process along with increasing age. The development and growth in the process will change gradually according to the stages. Most of these changes occur in women because in the aging process a phase occurs, namely the menopause phase. Many premenopausal women complain that with the arrival of menopause they will become anxious, they are anxious towards the end of their reproductive period and realize that they will grow old which means their beauty will fade and the function of their organs will decrease, thereby eliminating their pride as a woman This study aims to determine the factors associated with premenopausal anxiety levels in Karajan Barat Village of Cikampek Barat District of Karawang Regency in 2021. This study uses a correlational analytic study with a cross-sectional approach. The sample in this study amounted to 72 premenopausal women. The sampling technique used the purposive sampling technique. The research instrument consisted of a questionnaire about education level, knowledge level, financial material assets, family support, and socio-cultural support. This questionnaire has been tested for validity using Cronbach's alpha with an r table value of 0.514 and reliability testing with a value >0.6. The anxiety questionnaire using Hamilton Rating Scale for Anxiety (HAR-S). The data were analyzed using the chi-square correlation test with a significant level of <0.05 to determine the relationship between education level, knowledge level, financial material assets, family support, and socio-cultural support with premenopausal anxiety level. The results showed that the relationship between education level and anxiety obtained a p-value of 0.689 (p>0.05). The relationship between the level of knowledge and anxiety obtained a p-value of 0.009 (p <0.05). The relationship between financial material assets and anxiety has a p-value of 0.58 (p>0.05). The relationship between family support and anxiety has a p-value of 0.001 (p <0.05). The socio-cultural relationship between support and anxiety has a p-value of 0.000 (p<0.05). The conclusion of this research is there is a significant relationship between the level of knowledge, family support, and socio-cultural support to the level of anxiety of premenopausal. There is no significant relationship between the level of education and financial material assets on the level of anxiety of premenopausal women.

Keywords: Premenopausal, Education, Knowledge, Financial Material Assets, Family Support, Socio-Cultural Support, Anxiety.
Hubungan Tingkat Kecemasan Dan Pengetahuan Ibu Hamil Trimester III Dengan Kesiapanan Dalam Menghadapi Persalinan Di Masa Pandemi Covid-19 Di BPS Lidia Mardalena Kota Tangerang Tahun 2021
Authors: - Ida Istiqomah
Published: May 2023

Tingkat Kecemasan ibu hamil pada masa Pandemi Covid-19 mengalami peningkatan yang signifikan dan beresiko terhadap janin. Pengetahuan tentang persalinan mempunyai peranan penting yang berhubungan dengan persiapan dalam menghadapi persalinan. Kecemasan ibu hamil sangat mempengaruhi persalinannya, semakin cemas ibu ibu hamil maka akan semakin kurang dalam mempersiapkan persalinannya. Tujuan penelitian ini mengetahui hubungan tingkat Kecemasan Dan Pengetahuan ibu hamil trimester III Dengan kesiapan dalam menghadapi persalinan di masa Pandemi Covid-19. Penelitian observasional analitik ini menggunakan rancangan cross sectional. Sampel dalam.penelitian ini berjumlah 43 responden ibu hamil trimester III. Teknik pengambilan sampel menggunakan total sampling. Instrumental penelitian ini berupa kuesioner. Kuesioner ini telah diuji validitas dan reliabilitasnya dengan nilai koefisien cronbach's alpha 0,965. Data dianalisis menggunakan uji statistik chi-square. Hasil penelitian menunjukkan nilai p value tingkat Kecemasan ibu hamil trimester III dalam menghadapi persalinan sebesar 0,002. Nilai p value pengetahuan ibu hamil trimester III dengan kesiapan dalam menghadapi persalinan sebesar 0,014. Simpulan penelitian ini adalah terdapat hubungan yang signifikan antara tingkat Kecemasan dan pengetahuan ibu hamil trimester III dengan kesiapan dalam menghadapi persalinan di masa Pandemi Covid-19 di BPS Lidia Mardalena Kota Tangerang Tahun 2021.
Faktor-Faktor Penyebab Infeksi Masa Nifas
Authors: Idyawati Susilia
Published: May 2023

Infeksi nifas merupakan salah satu faktor penyebab kematian ibu, diperkirakan kematian ibu diakibatkan kehamilan setelah persalinan dan pada masa nifas dalam 24 jam pertama. Penelitian ini bertujuan untuk mengetahui faktor penyebab infeksi pada masa nifas. Metode Penelitian studi literature review didapatkan 10 artikel yang selanjutnya akan direview. Berdasarkah hasil dari 10 artikel yang dipilih untuk review di Negara-negara yang ada di Benua Afrika seperti Kenya, Ethiopia, Kamerun dan Nepal didapatkan faktor penyebab terjadinya infeksi masa nifas berdasarkan hasil penelitian disebabkan karena faktor langsung dan faktor yang tidak langsung. Faktor langsung penyebab infeksi nifas yaitu karena pemeriksaan dalam (VT) yang terlalu sering partus lama, proses persalinan kala 2 dengan sectio sesaria, setelah masa nifas yang disebabkan karena personal higine yang rendah penyebab tidak langsung dari infeksi berdasarkan hasil review yaitu tempat tinggal, tingkat pendidikan, pengetahuan, ketersediaan makanan, tempat bersalin IMT,  riwayat kunjungan antenatal care, riwayat diabetes mellitus dan anemia. Dapat disimpulkan Faktor Penyebab Infeksi Masa nifas terdiri dari Penyebab Langsung dan Tidak langsung.
Efektivitas Ekstrak Binahong (Andredera cordifolia steenis) Terhadap Salmonella typhi secara in Vitro
Authors: Suhada Adriyan , Halid Musparlin , Ratia Ratulangi Wulan , Dewi Susilawati Wulandari , Hasanah Uswatun , Pratam Adi Putra Rizal , Pauzan  , M.Si Hardani
Published: May 2023

Binahong (Anredera cordifolia steenis) is one of the plants that has the potential to be developed as a raw material for antibiotic drugs. Typhoid fever is a systemic infection caused by Salmonella typhi (S. typhi). Salmonella paratyphi A, B, and C can also cause an infection called paratyphoid fever. Typhoid and paratyphoid fever are included in enteric fever. In endemic areas, about 90% of enteric fever is typhoid fever. This study is a true experimental in the Biology lab of Politeknik Medica Farma Husada Mataram using the well method with 5 treatments, the treatment was repeated 6x with various concentrations of 100%, 80%, 60%, 40%, and 20%, and cipropolacin antibiotics were used as positive controls and ethyl acetate as a negative control, the material used is thick extract of binahong leaves, after the thick extract of binahong leaves is produced, then the antibacterial inhibition test is carried out against the growth of salmonella thypi bacteria in vitro, the parameter observed is the diameter of the antibacterial inhibition zone of salmonella thypi, ANOVA test data analysis. The results showed that binahong leaves have the ability to inhibit the growth of salmonella thypi bacteria with the inhibition zone formed. The average inhibition zone of binahong leaf extract (Anredera Cardifolia Steenis) is 20% concentration of 18mm, 40% concentration of 12 mm, 60% concentration of 15mm, 80% concentration of 19 mm, and 100% concentration of 24mm.
A Case Report of a Patient Who Had Intravaginal Leech Application
Authors: Aksu Arif , Küçük Ömer Faruk , Güler Muhammed Ali , Keleş Sami , Dumrul Aybars Furkan
Published: May 2023

Intravaginal leech application is a traditional medical practice used in some cultures to treat various gynecological conditions. Leeches are believed to improve blood circulation and promote healing in the affected area. Studies have shown that the bioactive substances injected by leeches, when their mechanisms of action are examined, can be used in the treatment of many diseases. In this case report, we present a case of vaginal bleeding after intravaginal leech application.
Stress Among Dental Students And Its Association With Substance Abuse– A Cross-Sectional Study
Authors: Rajeev Ananthalekshmy , Kumari Monika
Published: May 2023

Introduction: Dental education is supposed as an extremely challenging and enormously stressful experience globally. This resultant stress can lead to depression, anxiety, absenteeism, diminished work efficiency, sleep problems, lower academic performances, and burnout. Moreover, it has also been interrelated with drug addiction and substance abuse.The present study was conducted to find out the association of Stress with Substance Abuse among Dental Students in Ghaziabad, India.

Methodology:This is a descriptive Cross-sectional study conducted among 275 dental students. Dental Environmental Stress (DES) questionnaire was used to gather the data regarding stress. The assembled data was exposed to frequency distribution analysis using the Statistical Package for the Social Sciences software (SPSS) 21.0v. Association of Level of Stress with Substance Abuse among Dental Students was assessed using Chi-square analysis with ap value ≤0.05 considered statistically significant.

Results:The response rate of this study was 91.2%. Out of the 251 study participants, 65.3% were females and 34.7% were males. The mean age of the study subjects was 24.20 ± 3.688. According to the level of stress, there were 18.7% highly stressed students among which 46.8% were having smoking habit and 14.9% consumed alcohol regularly. Association of level of stress with smoking was found to be statistically significant (p≤0.05) whereas its association with alcohol consumption was not statistically significant.

Conclusion: In the present study, there is a high prevalence of stress among the dental students and most of the highly stressed students were having habit of smoking. So, it can be concluded that stress have a significant association with smoking but its association with alcohol is uncertain.

Keywords:Alcohol drinking,Dental students, Psychological Stress, Smoking, Substance-related disorders.
Knowledge, Awareness & Attitude regarding Dental Implants among Dental Interns in Central Vidarbha
Authors: Bhangadia Ayush , Bhangadia Ranu , Mankar Kamalkishor
Published: May 2023

BACKGROUND Implant therapy is an elective dental procedure of dental rehabilitative treatment. The aim of this study was to assess the knowledge, awareness, and attitude of dental interns of Central Vidarbha toward dental implants. A dental implant is a surgical component that interfaces with the bone of the jaw or skull to support a dental prosthesis such as a crown, bridge, denture, facial prosthesis or to act as an orthodontic anchor. MATERIAL AND METHODS The analysis protocol was approved by the institutional ethical committee of college. The study was administered out on dental interns studying in dental colleges of Central Vidarbha A cross-sectional based study was designed. A questionnaire was distributed among Intern of Dental Colleges in Central Vidarbha There were total 300 interns from all the dental colleges of central vidarbha but only 287 interns participated in study. There were about 57 male students and 230 female students. The questionnaire consisted of total 15 questions. The entire questionnaire was got validated. The Inclusion criterion was all the willing interns of all dental institutes in Central Vidarbha. The unwilling students were the exclusion criteria. The questionnaire was distributed in form of Google forms The study has been conducted between the periods of January 2021 to June 2021 RESULT 97.9% (281) interns were aware that Dental implant as an alternative treatment modality for missing teeth, 68.6% (197) of interns agreed that implants can have technical and biological complications, 49.8% (143) interns thought that long lasting is the main advantage of dental implants over fixed prosthesis, 45.3% (130) interns thought that case selection is most important factor for implant success. CONCLUSION It can be concluded that the knowledge, awareness, and attitude regarding dental implant is moderately present among dental interns. As the implant therapy is becoming an emerging practice in dentistry nowadays because of its advantages, it is important to train the dental interns regarding it so that they can successfully treat the patient.They were anxious to find more about the dental implants. More writing and practice work ought to be added on the BDS educational plan and interns should be anchorage to assist the implant procedure. The dental institutes should also understand the problems faced by students regarding dental implants and should give importance to this topic during BDS curriculum. KEYWORDS Knowledge, awareness, attitude, dental implants, dental interns, central vidarbha
Effect of sensitization on Oral Hygiene Knowledge, Attitude & Practices among the nursing students
Authors: Bale Akansha , Kahar Anita , Joshi Jayashree
Published: May 2023

Background-
Nursing staff isthe connecting link between the doctors and their patients. With profound knowledge of oral hygiene, they can upgrade,enhance and inculcate good oral hygiene practices among their patients, thereby sets thinking and triggers of giving more comprehensive knowledge to the nurses.Hence,we decided to conduct the present study to assess the oral health knowledge, attitude and practices among the nursing students of VidyaShikshakPrasarak Mandal (VSPM) college of Nursing.

Materials and Methods – A 22 item pre-validated close ended questionnaire based on knowledge, attitude and practices of oral hygiene were being filled by 425 nursing students following a sensitization lecture was delivered. After a month, the same questionnaire was filled by the same participants. The answers of pre and post sensitization lecture were compared.

Result- The response towards use of fluoridated toothpaste had increased to 268(63%) which was initially 170 (40%).The frequency for visiting the dentist had increased to 241( 57%)which was initially to a much lower number,i.e.,75 ( 18%)
Conclusion –Sensitization lectures given to the nursing students have proved to be of assistance in upgrading the knowledge of oral hygiene practices to the nursing students to the core.

KeyWords- Nursing students, oral hygiene, knowledge, attitude, practices, sensitization.
Knowledge And Use Of Electronic Information Resources Among Dental And Nursing Students In Ghaziabad – A Cross-Sectional Study
Authors: Kumari Monika , Rajeev Ananthalekshmy
Published: May 2023

Introduction: E-resources are boons to the medical students in their busy schedule. These e-resources are appropriate to use, accessible at a reasonable price and can be retrieved from anywhere by many users at the same time.Resources and information regarding dental product, continuing education, online catalogs, etc have resulted in making Internet increasingly popular in dentistry.The present study was conducted to evaluate the knowledge and use of electronic resources among Dental and Nursing students in Ghaziabad.

Methodology:The present study was conducted in Ghaziabad district among 400 medical students (200 dental and 200 nursing students) whom were selected using random sampling techniques.The data were compiled and tabulated in Microsoft Excel spreadsheet and were subjected to descriptive analysis using the Statistical Package for the Social Sciences software (SPSS) 21.0 (SPSS Inc., Chicago, IL, USA).

Results:In the present study, 25% of students were first years, 16.25% were second years, 21.75% were third years, 11.5% were fourth years and the rest 25.5% were interns. 96% dental and 94.5% nursing students in this study were aware of e-databases. Almost 43.75% heard about PubMed, 13% about Medline plus and 4.75% about web of science databases but only 22.5% dental and 11.5% nursing students used PubMed while 6%dental and 4.5%nursing students used Medline plus.

Conclusion:The present study concludes that there is an inadequacy of knowledge about e-databases among both the dental and nursing students in Ghaziabad.

Keywords: Awareness, Dental students, Electronic Databases, Knowledge, Nursing students
Vibrio cholerae RND efflux systems: mediators of stress responses, colonization and pathogenesis
Authors: Bina X. Renee , Bina James E.
Published: May 2023

Resistance Nodulation Division (RND) efflux systems are ubiquitous transporters in gram-negative bacteria that provide protection against antimicrobial agents and thereby enhance survival in virtually all environments these prokaryotes inhabit. Vibrio cholerae is a dual lifestyle enteric pathogen that spends much of its existence in aquatic environments. An unwitting encounter with a human host can lead to V. cholerae intestinal colonization by strains that encode cholera toxin and toxin co-regulated pilus virulence factors leading to potentially fatal cholera diarrhea and dissemination in the environment. Adaptive response mechanisms to host factors encountered by these pathogens are therefore critical both to engage survival mechanisms such as RND-mediated transporters and to induce timely expression of virulence factors. Sensing of cues encountered in the host may therefore activate more than protective responses such as efflux systems, but also be coordinated to initiate expression of virulence factors. This review summarizes recent advances that contribute towards the understanding of RND efflux physiological functions and how the transport systems interface with the regulation of virulence factor production in V. cholerae.
Yes we can? Effects of a participatory visioning process on perceived climate efficacy
Authors: Peisker Jonas , Schinko Thomas
Published: May 2023

Lack of perceived efficacy can be an important barrier to climate mitigation action at various scales. Here, we study how a participatory visioning process, the Climate Modernity workshop in Styria, Austria, affected participants' efficacy outcomes. To this end, we conducted two survey waves eliciting self- and response efficacy regarding possible mitigation measures. We estimate difference-in-differences models and corroborate the findings using qualitative participant feedback. The results indicate that the intervention tended to decrease personal self-efficacy, in particular with regard to controversial topics like the transformation of the transport system. This suggests that participatory stakeholder processes can draw attention to the conflict potential and complexity of specific mitigation policies, decreasing the perceived feasibility of implementing them. The workshop, however, tended to increase particpants' personal response efficacy, particularly regarding voting for pro-environmental candidates. Accordingly, participatory processes could raise trust in the democratic process and in the effectiveness of making a green voting decision.
Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research
Authors: Schreiber Laura M. , Lohr David , Baltes Steffen , Vogel Ulrich , Elabyad Ibrahim A. , Bille Maya , Reiter Theresa , Kosmala Aleksander , Gassenmaier Tobias , Stefanescu Maria R. , Kollmann Alena , Aures Julia , Schnitter Florian , Pali Mihaela , Ueda Yuichiro , Williams Tatiana , Christa Martin , Hofmann Ulrich , Bauer Wolfgang , Gerull Brenda , Zernecke Alma , Ergün Süleyman , Terekhov Maxim
Published: May 2023

A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is becoming increasingly available for imaging of the heart and, when compared to clinically established field strengths, promises better image quality and image information content, more precise functional analysis, potentially new image contrasts, and as all in-vivo imaging techniques, a reduction of the number of animals per study because of the possibility to scan every animal repeatedly. We present here a solution to the dual use problem of whole-body UHF-MRI systems, which are typically installed in clinical environments, to both UHF-MRI in large animals and humans. Moreover, we provide evidence that in such a research infrastructure UHF-MRI, and ideally combined with a standard small-bore UHF-MRI system, can contribute to a variety of spatial scales in translational cardiovascular research: from cardiac organoids, Zebra fish and rodent hearts to large animal models such as pigs and humans. We present pilot data from serial CINE, late gadolinium enhancement, and susceptibility weighted UHF-MRI in a myocardial infarction model over eight weeks. In 14 pigs which were delivered from a breeding facility in a national SARS-CoV-2 hotspot, we found no infection in the incoming pigs. Human scanning using CINE and phase contrast flow measurements provided good image quality of the left and right ventricle. Agreement of functional analysis between CINE and phase contrast MRI was excellent. MRI in arrested hearts or excised vascular tissue for MRI-based histologic imaging, structural imaging of myofiber and vascular smooth muscle cell architecture using high-resolution diffusion tensor imaging, and UHF-MRI for monitoring free radicals as a surrogate for MRI of reactive oxygen species in studies of oxidative stress are demonstrated. We conclude that UHF-MRI has the potential to become an important precision imaging modality in translational cardiovascular research.
Comparison of long-term outcome in patients with calcified stenosis treated with intravascular lithotripsy or with modified balloon angioplasty: a propensity score-adjusted study
Authors: Leick Jürgen , Rheude Tobias , Denne Michael , Cassese Salvatore , Kastrati Adnan , Hauptmann Felix , Gehrig Thomas , Kuna Constantin , Lindner Michael , Lauterbach Michael , Werner Nikos
Published: May 2023

Background

The aim of this two-center, all-comers registry was to compare the effectiveness and safety of intravascular lithotripsy (IVL) to that of modified balloon angioplasty (MB). MB angioplasty using a cutting or scoring balloon is commonly used in patients with calcified coronary arteries. IVL is a new technology for lesion preparation. This is the first study to compare MB with IVL.

Methods

The cohort included all patients treated by MB angioplasty or IVL between 2019 and 2021. The primary endpoint was strategy success (<20% residual stenosis). The secondary endpoint was long-term safety outcomes [cardiac death, acute myocardial infarction (AMI), target lesion failure/revascularization (TVR)]. Quantitative coronary angiography (QCA) was performed in all patients. Primary and secondary endpoints were compared using inverse probability of treatment weighting (IPTW) for treatment effect estimation.

Results

A total of n = 86 patients were treated by IVL and n = 92 patients by MB angioplasty. The primary endpoint was reached in 152 patients (85.4%). Patients in the IVL group had less residual stenosis (5.8% vs. 22.8%; p = 0.001) in QCA. Weighted multivariable regression analysis revealed that IVL had a significant positive effect on reaching the primary endpoint of strategy success [odds ratio (OR) 24.58; 95% confidence interval (95% CI) 7.40–101.86; p = 0.001]. In addition, severe calcification was shown to result in a lower probability of achieving the primary endpoint (OR 0.08; 95% CI 0.02–0.24; p = 0.001). During the follow-up period (450 days) there was no difference in cardiovascular mortality rate [IVL (n = 5) 2.8% vs. MB (n = 3) 1.7%; p = 0.129]. Patients with unstable angina at the time of the index procedure had the highest probability of cardiovascular death [hazard ratio (HR) 7.136; 95% CI 1.248–40.802; p = 0.027]. No differences were found in long-term rates of AMI (IVL 1.7% vs. MB 2.8%; p = 0.399; IVL HR 2.73; 95% CI 0.4–17.0; p = 0.281) or TVR (IVL 5.6% vs. MB 9%; p = 0.186; IVL HR 0.78; 95% CI 0.277–2.166; p = 0.626).

Conclusion

IVL leads to a significantly better angiographic intervention outcome compared to MB angioplasty in our cohort. During long-term follow-up, no differences in cardiovascular mortality, rate of acute myocardial infarction, or target lesion failure/revascularization were observed.
Building the foundation for a modern patient-partnered infrastructure to study temporomandibular disorders
Authors: Gressler Laura Elisabeth , Cowley Terrie , Velezis Marti , Aryal Suvekshya , Clare Deanne , Kusiak John W. , Cowley Allen W. , Sedrakyan Art , Marinac-Dabic Danica , Reardon Michelle , Schmidt Lisa , Feldman Jennifer Ginsburg , DiFabio Vincent , Bergman Suzie , Simonyan Vahan , Yesha Yelena , Vasiliu-Feltes Ingrid , Durham Justin , Steen Andrew I. , Woods Phillip , Kapos Flavia P. , Loyo-Berrios Nilsa
Published: May 2023

Background

Conflicting reports from varying stakeholders related to prognosis and outcomes following placement of temporomandibular joint (TMJ) implants gave rise to the development of the TMJ Patient-Led RoundTable initiative. Following an assessment of the current availability of data, the RoundTable concluded that a strategically Coordinated Registry Network (CRN) is needed to collect and generate accessible data on temporomandibular disorder (TMD) and its care. The aim of this study was therefore to advance the clinical understanding, usage, and adoption of a core minimum dataset for TMD patients as the first foundational step toward building the CRN.

Methods

Candidate data elements were extracted from existing data sources and included in a Delphi survey administered to 92 participants. Data elements receiving less than 75% consensus were dropped. A purposive multi-stakeholder sub-group triangulated the items across patient and clinician-based experience to remove redundancies or duplicate items and reduce the response burden for both patients and clinicians. To reliably collect the identified data elements, the identified core minimum data elements were defined in the context of technical implementation within High-performance Integrated Virtual Environment (HIVE) web-application framework. HIVE was integrated with CHIOS™, an innovative permissioned blockchain platform, to strengthen the provenance of data captured in the registry and drive metadata to record all registry transaction and create a robust consent network.

Results

A total of 59 multi-stakeholder participants responded to the Delphi survey. The completion of the Delphi surveys followed by the application of the required group consensus threshold resulted in the selection of 397 data elements (254 for patient-generated data elements and 143 for clinician generated data elements). The infrastructure development and integration of HIVE and CHIOS™ was completed showing the maintenance of all data transaction information in blockchain, flexible recording of patient consent, data cataloging, and consent validation through smart contracts.

Conclusion

The identified data elements and development of the technological platform establishes a data infrastructure that facilitates the standardization and harmonization of data as well as perform high performance analytics needed to fully leverage the captured patient-generated data, clinical evidence, and other healthcare ecosystem data within the TMJ/TMD-CRN.
Inflammatory myofibroblastic tumor of the thyroid gland
Authors: Zhang Yiyang , Liu Jia
Published: May 2023

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor with low incidence, which is extremely rare in the thyroid. At present, there is a lack of understanding regarding the etiology, pathogenesis, diagnosis and treatment of thyroid IMT. To improve the understanding of the disease, this article reviews the pathogenesis, clinical manifestations, pathology and immunohistochemistry, diagnosis, therapy and prognosis of thyroid IMT.
Impact of continuous glucose monitoring on glycemic control and its derived metrics in type 1 diabetes: a longitudinal study
Authors: Cho So Hyun , Kim Seohyun , Lee You-Bin , Jin Sang-Man , Hur Kyu Yeon , Kim Gyuri , Kim Jae Hyeon
Published: May 2023

Aim

We explored the effectiveness of continuous glucose monitoring for 1 year on glycated A1c reduction in adults with type 1 diabetes mellitus.

Methods

We included type 1 diabetes mellitus adults who were either new continuous glucose monitoring users (N = 155) or non-users who were under standard care (N = 384). Glycated A1c was measured at baseline and 3, 6, 9, and 12 months. Individuals with (N = 155) or without continuous glucose monitoring use (N = 310) were matched 1:2 by propensity score. We used the linear mixed models to identify the quantitative reduction in repeated measures of glycated A1c.

Results

The change in glycated A1c from baseline to 12 months was −0.5% ± 1.0% for the continuous glucose monitoring user group (N = 155, P < 0.001) and −0.01% ± 1.0% for the non-user group (N = 310, P = 0.816), with a significant difference between the two groups (P = 0.003). Changes in glycated A1c were significant at 3, 6, 9, and 12 months compared with those at baseline in patients using continuous glucose monitoring (P < 0.001), and the changes differed significantly between the groups (P < 0.001). A linear mixed model showed an adjusted treatment group difference in mean reduction in glycated A1c of −0.11% (95% confidence interval, −0.16 to −0.06) each three months. In the continuous glucose monitoring user group, those who achieved more than 70% of time in range significantly increased from 3 months (37.4%) to 12 months (48.2%) (P < 0.001).

Conclusion

In this longitudinal study of type 1 diabetes mellitus adults, the use of continuous glucose monitoring for 1 year showed a significant reduction in glycated A1c in real-world practice.
From glucose sensing to exocytosis: takes from maturity onset diabetes of the young
Authors: Samadli Sama , Zhou Qiaoli , Zheng Bixia , Gu Wei , Zhang Aihua
Published: May 2023

Monogenic diabetes gave us simplified models of complex molecular processes occurring within β-cells, which allowed to explore the roles of numerous proteins from single protein perspective. Constellation of characteristic phenotypic features and wide application of genetic sequencing techniques to clinical practice, made the major form of monogenic diabetes – the Maturity Onset Diabetes of the Young to be distinguishable from type 1, type 2 as well as neonatal diabetes mellitus and understanding underlying molecular events for each type of MODY contributed to the advancements of antidiabetic therapy and stem cell research tremendously. The functional analysis of MODY-causing proteins in diabetes development, not only provided better care for patients suffering from diabetes, but also enriched our comprehension regarding the universal cellular processes including transcriptional and translational regulation, behavior of ion channels and transporters, cargo trafficking, exocytosis. In this review, we will overview structure and function of MODY-causing proteins, alterations in a particular protein arising from the deleterious mutations to the corresponding gene and their consequences, and translation of this knowledge into new treatment strategies.
New mitogenomes in deep-water endemic Cocculinida and Neomphalida shed light on lineage-specific gene orders in major gastropod clades
Authors: Zhong Zhaoyan , Lan Yi , Chen Chong , Zhou Yadong , Linse Katrin , Li Runsheng , Sun Jin
Published: May 2023

Gastropoda is the most speciose class in Mollusca, the second largest animal phylum. The internal relationships of major gastropod groups remain largely unsettled, partly due to the insufficient data from key deep-water endemic lineages such as the subclass Neomphaliones. Neomphaliones currently includes two orders: Cocculinida, best known from sunken wood habitats, and Neomphalida, best known from hydrothermal vents and often referred to as the “hot vent clade.” Phylogenetic controversy has also been observed in this subclass across different studies, requesting additional investigations. Here, we assembled nine new mitogenomes from two Cocculinida and seven Neomphalida species and analyzed them with published gastropod mitogenomes, with a particular focus on Neomphaliones. The phylogenetic reconstruction of Gastropoda based on 13 mitochondrial protein-coding genes resulted in a topology largely congruent with previous reconstructions based on morphological characters. Furthermore, we recovered characteristic mitochondrial gene order arrangements of Cocculinida and Neomphalida compared to the hypothetical ancestral gastropod gene order, at a level similar to other subclass-level clades. Divergence time estimation showed that Cocculinida and Neomphalida diverged approximately 322.68 million years ago. In addition to characteristic gene order arrangements for the clade, Cocculinida mitogenomes also exhibit some minor rearrangements even among congeners. Within Neomphalida, our tree adds support to monophyletic Peltospiridae and Neomphalidae, with unique gene arrangement recovered for each family. Our results offer new insights into the rearrangement of mitogenomes in Gastropoda, providing another clue to the evolutionary history of gastropods.