bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational tissue staining of non-linear multimodal imaging using supervised and unsupervised deep learning
Authors: Pradhan Pranita , Meyer Tobias , Vieth Michael , Stallmach Andreas , Waldner Maximilian , Schmitt Michael , Popp Juergen , Bocklitz Thomas
Published: February 2021

Hematoxylin and Eosin (H&E) staining is the ’gold-standard’ method in histopathology. However, standard H&E staining of high-quality tissue sections requires long sample preparation times including sample embedding, which restricts its application for ’real-time’ disease diagnosis. Due to this reason, a label-free alternative technique like non-linear multimodal (NLM) imaging, which is the combination of three non-linear optical modalities including coherent anti-Stokes Raman scattering, two-photon excitation fluorescence and second-harmonic generation, is proposed in this work. To correlate the information of the NLM images with H&E images, this work proposes computational staining of NLM images using deep learning models in a supervised and an unsupervised approach. In the supervised and the unsupervised approach, conditional generative adversarial networks (CGANs) and cycle conditional generative adversarial networks (cycle CGANs) are used, respectively. Both CGAN and cycle CGAN models generate pseudo H&E images, which are quantitatively analyzed based on mean squared error, structure similarity index and color shading similarity index. The mean of the three metrics calculated for the computationally generated H&E images indicate significant performance. Thus, utilizing CGAN and cycle CGAN models for computational staining is beneficial for diagnostic applications without performing a laboratory-based staining procedure. To the author’s best knowledge, it is the first time that NLM images are computationally stained to H&E images using GANs in an unsupervised manner.
Dual-view light-sheet imaging through a tilted glass interface using a deformable mirror
Authors: Vladimirov Nikita , Preusser Friedrich , Wisniewski Jan , Yaniv Ziv , Desai Ravi Anand , Woehler Andrew , Preibisch Stephan
Published: February 2021

Light-sheet microscopy has become indispensable for imaging developing organisms, and imaging from multiple directions (views) is essential to improve its spatial resolution. We combine multi-view light-sheet microscopy with microfluidics using adaptive optics (deformable mirror) which corrects aberrations introduced by the 45o-tilted glass coverslip. The optimal shape of the deformable mirror is computed by an iterative algorithm that optimizes the point-spread function in two orthogonal views. Simultaneous correction in two optical arms is achieved via a knife-edge mirror that splits the excitation path and combines the detection paths. Our design allows multi-view light-sheet microscopy with microfluidic devices for precisely controlled experiments and high-content screening.
Data-driven method to infer the seizure propagation patterns in an epileptic brain from intracranial electroencephalography
Authors: Sip Viktor , Hashemi Meysam , Vattikonda Anirudh N. , Woodman Marmaduke M. , Wang Huifang , Scholly Julia , Medina Villalon Samuel , Guye Maxime , Bartolomei Fabrice , Jirsa Viktor K.
Published: February 2021

Surgical interventions in epileptic patients aimed at the removal of the epileptogenic zone have success rates at only 60-70%. This failure can be partly attributed to the insufficient spatial sampling by the implanted intracranial electrodes during the clinical evaluation, leading to an incomplete picture of spatio-temporal seizure organization in the regions that are not directly observed. Utilizing the partial observations of the seizure spreading through the brain network, complemented by the assumption that the epileptic seizures spread along the structural connections, we infer if and when are the unobserved regions recruited in the seizure. To this end we introduce a data-driven model of seizure recruitment and propagation across a weighted network, which we invert using the Bayesian inference framework. Using a leave-one-out cross-validation scheme on a cohort of 45 patients we demonstrate that the method can improve the predictions of the states of the unobserved regions compared to an empirical estimate that does not use the structural information, yet it is on the same level as the estimate that takes the structure into account. Furthermore, a comparison with the performed surgical resection and the surgery outcome indicates a link between the inferred excitable regions and the actual epileptogenic zone. The results emphasize the importance of the structural connectome in the large-scale spatio-temporal organization of epileptic seizures and introduce a novel way to integrate the patient-specific connectome and intracranial seizure recordings in a whole-brain computational model of seizure spread.
Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning
Authors: He Jinzhi , Jing Junjun , Feng Jifan , Han Xia , Yuan Yuan , Guo Tingwei , Pei Fei , Ma Yuanyuan , Cho Courtney , Ho Thach-Vu , Chai Yang
Published: February 2021

Mammalian tooth crown formation has long served as a model for investigating how patterning and morphogenesis are orchestrated during development. However, the mechanism underlying root patterning and morphogenesis remains poorly understood. In this study, we find that Lhx6 labels a subpopulation of root progenitor cells in the apical dental mesenchyme, which is closely associated with furcation development. Loss of Lhx6 leads to furcation and root number defects, indicating that Lhx6 is a key root patterning regulator. Among the multiple cellular events regulated by Lhx6 is the odontoblast fate commitment of progenitor cells, which it controls in a cell-autonomous manner. Specifically,Lhx6loss leads to elevated expression of the Wnt antagonistSfrp2and down-regulation of Wnt signaling in the furcation region, while overactivation of Wnt signaling in Lhx6+ progenitor cells partially restore the furcation defects inLhx6-/-mice. Collectively, our findings have important implications for understanding organ morphogenesis and future strategies for tooth root regeneration.
Universal time preference
Authors: Rieger Marc Oliver , Wang Mei , Hens Thorsten
Published: February 2021

Time preferences are central to human decision making; therefore, a thorough understanding of their international differences is highly relevant. Previous measurements, however, vary widely in their methodology, from questions answered on the Likert scale to lottery-type questions. We show that these different measurements correlate to a large degree and that they have a common factor that can predict a broad spectrum of variables: the countries’ credit ratings, gasoline prices (as a proxy for environmental protection), equity risk premiums, and average years of school attendance. The resulting data on this time preference factor forN= 117 countries and regions will be highly useful for further research. Our aggregation method is applicable to merge cross-cultural studies that measure the same latent construct with different methodologies.
A randomised experiment of health, cost and social norm message frames to encourage acceptance of swaps in a simulation online supermarket
Authors: Bunten Amanda , Porter Lucy , Sanders Jet G. , Sallis Anna , Payne Riches Sarah , Van Schaik Paul , González-Iraizoz Marta , Chadborn Tim , Forwood Suzanna
Published: February 2021

Offering lower-energy food swaps to customers of online supermarkets could help to decrease energy (kcal) purchased and consumed. However, acceptance rates of such food swaps tend to be low. This study aimed to see whether framing lower-energy food swaps in terms of cost savings or social norms could improve likelihood of acceptance relative to framing swaps in terms of health benefits. Participants (n = 900) were asked to shop from a 12-item shopping list in a simulation online supermarket. When a target high-energy food was identified in the shopping basket at check-out, one or two lower-energy foods would be suggested as an alternative (a “swap”). Participants were randomised to only see messages emphasising health benefits (fewer calories), cost benefits (lower price) or social norms (others preferred this product). Data were analysed for 713 participants after exclusions. Participants were offered a mean of 3.17 swaps (SD = 1.50), and 12.91% of swaps were accepted (health = 14.31%, cost = 11.49%, social norms = 13.18%). Swap acceptance was not influenced by the specific swap frame used (all p > .170). Age was significantly and positively associated with swap acceptance (b = 0.02, SE = 0.00, p < .001), but was also associated with smaller decreases in energy change (b = 0.46, SE = .19, p = .014). Overall, offering swaps reduced both energy (kcal) per product (b = -9.69, SE = 4.07, p = .017) and energy (kcal) per shopping basket (t712 = 11.09, p < .001) from pre- to post-intervention. Offering lower-energy food swaps could be a successful strategy for reducing energy purchased by customers of online supermarkets. Future research should explore alternative solutions for increasing acceptance rates of such swaps.
Direct healthcare costs of lip, oral cavity and oropharyngeal cancer in Brazil
Authors: Milani Vanessa , Zara Ana Laura de Sene Amâncio , da Silva Everton Nunes , Cardoso Larissa Barbosa , Curado Maria Paula , Ribeiro-Rotta Rejane Faria
Published: February 2021

The efficiency of public policies includes the measurement of the health resources used and their associated costs. There is a lack of studies evaluating the economic impact of oral cancer (OC). This study aims to estimate the healthcare costs of OC in Brazil from 2008 to 2016. This is a partial economic evaluation using the gross costing top-down method, considering the direct healthcare costs related to outpatients, inpatients, intensive care units, and the number of procedures, from the perspective of the public health sector. The data were extracted from the Outpatient and Inpatient Information System of the National Health System, by diagnosis according to the 10th Revision of the International Classification of Diseases, according to sites of interest: C00 to C06, C09 and C10. The values were adjusted for annual accumulated inflation and expressed in 2018 I$ (1 I$ = R$2,044). Expenditure on OC healthcare in Brazil was I$495.6 million, which was composed of 50.8% (I$251.6 million) outpatient and 49.2% (I$244.0 million) inpatient healthcare. About 177,317 admissions and 6,224,236 outpatient procedures were registered. Chemotherapy and radiotherapy comprised the largest number of procedures (88.8%) and costs (94.9%). Most of the costs were spent on people over 50 years old (72.9%) and on males (75.6%). Direct healthcare costs in Brazil for OC are substantial. Outpatient procedures were responsible for the highest total cost; however, inpatient procedures had a higher cost per procedure. Men over 50 years old consumed most of the cost and procedures for OC. The oropharynx and tongue were the sites with the highest expenditure. Further studies are needed to investigate the cost per individual, as well as direct non-medical and indirect costs of OC.
Disparities in potential years of life lost due to intimate partner violence: Data from 16 states for 2006–2015
Authors: Graham Laurie M. , Ranapurwala Shabbar I. , Zimmer Catherine , Macy Rebecca J. , Rizo Cynthia F. , Lanier Paul , Martin Sandra L.
Published: February 2021

Background

Intimate partner violence can lead to deaths of one or both partners and others (i.e., corollary victims). Prior studies do not enumerate the societal cost of intimate partner violence-related fatalities, exclude corollary victims from most analyses, and do not describe groups who bear the highest societal costs from intimate partner violence.

Objective

We examine racial/ethnic and gender-based disparities in potential years of life lost (PYLL) among intimate partners and corollary victims of intimate partner violence-related mortality.

Methods

We used 16 US states’ 2006–2015 National Violent Death Reporting System data to estimate PYLL among intimate partners (n = 6,282) and corollary victims (n = 1,634) by victims’ race/ethnicity and sex. We describe fatalities by sex, race/ethnicity, age, and victim-suspect relationships and used hierarchical linear models to examine PYLL per death differences by victims’ sex and race/ethnicity.

Results

Nearly 290,000 years of potential life were lost by partner and corollary victims as a result of IPV in 16 states during the decade of study. Most partner victims were female (59%); most corollary victims were male (76%). Female intimate partners died 5.1 years earlier (95% CI: 4.4., 5.9) than males, and female corollary victims died 3.6 years (1.9, 5.5) earlier than males. Racial/ethnic minorities died nine or more years earlier than their White counterparts. White males had the lowest PYLL per death of all sex/race groups.

Implications

Intimate partner violence-related fatalities exact a high societal cost, and the burden of that cost is disproportionately high among racial/ethnic minorities. Future interventions targeting specific sex and race/ethnic groups might help reduce disparities in intimate partner violence burden.
Impact of pre-analytic step duration on molecular diagnosis of toxoplasmosis for five types of biological samples
Authors: Brenier-Pinchart Marie-Pierre , Varlet-Marie Emmanuelle , Robert-Gangneux Florence , Filisetti Denis , Guitard Juliette , Sterkers Yvon , Yera Hélène , Pelloux Hervé , Bastien Patrick
Published: February 2021

Introduction

Toxoplasma-PCR is essential to diagnose ocular, cerebral, disseminated and congenital toxoplasmosis. This multicenter study evaluated the impact of sample storage duration at +4°C on PCR assay performances in order to propose guidelines for the storage of samples during shipment or/and before PCR.

Materials and methods

Five matrices, amniotic (AF), cerebrospinal (CSF), and bronchoalveolar lavage fluids (BALF), whole blood (WB) and buffy coat (BC), were artificially spiked with different amounts ofToxoplasma gondii(20, 100, 500 tachyzoites per mL of sample) or with previously infected THP1 cells. DNA extractions were performed at day 0 and after 2, 4 and 7 days of storage at +4°C. Each extract was amplified at least twice by real-time PCR.

Results

A total of 252 spiked samples was studied. No increase of crossing point was observed and all samples were positive for AF, BALF, BC and infected THP1-spiked WB after up to 7 days at 4°C. For CSF spiked with 20 parasites/mL, only 50% of PCR reactions were positive at D7 (p<0.05). For WB spiked with type II parasites, all reactions remained positive at D7 but amplifications were significantly delayed from D2; and for WB spiked with RH strain, the proportion of positive reactions decreased at D7.

Conclusion

The storage of clinical samples at +4°C is compatible with the molecular detection ofT.gondiiparasites. Provided that PCR assays are performed in duplicate, storage of samples is possible up to 7 days. However, from the fifth day onwards, and for samples susceptible to contain low parasitic loads, we recommend to perform the PCR in multiplicate.
The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirus
Authors: Martínez Yamelie A. , Guo Xianwu , Portales-Pérez Diana P. , Rivera Gildardo , Castañeda-Delgado Julio E. , García-Pérez Carlos A. , Enciso-Moreno José A. , Lara-Ramírez Edgar E.
Published: February 2021

The MERS-CoV, SARS-CoV, and SARS-CoV-2 are highly pathogenic viruses that can cause severe pneumonic diseases in humans. Unfortunately, there is a non-available effective treatment to combat these viruses. Domain-motif interactions (DMIs) are an essential means by which viruses mimic and hijack the biological processes of host cells. To disentangle how viruses achieve this process can help to develop new rational therapies. Data mining was performed to obtain DMIs stored as regular expressions (regexp) in 3DID and ELM databases. The mined regexp information was mapped on the coronaviruses’ proteomes. Most motifs on viral protein that could interact with human proteins are shared across the coronavirus species, indicating that molecular mimicry is a common strategy for coronavirus infection. Enrichment ontology analysis for protein domains showed a shared biological process and molecular function terms related to carbon source utilization and potassium channel regulation. Some of the mapped motifs were nested on B, and T cell epitopes, suggesting that it could be as an alternative way for reverse vaccinology. The information obtained in this study could be used for further theoretic and experimental explorations on coronavirus infection mechanism and development of medicines for treatment.
Risk factors associated with cardiovascular disease among adult Nevadans
Authors: Tran Dieu-My T. , Lekhak Nirmala , Gutierrez Karen , Moonie Sheniz
Published: February 2021

Objective

Cardiovascular disease (CVD) remains the number one cause of death in the US and Nevada is ranked 11th highest for CVD mortality. The study sought to examine the association between self-reported risk factors and CVD presence among adult Nevadans, between years 2011 and 2017.

Methods

This is a cross-sectional, population-based study that utilized the 2011 and 2017 Nevada Behavioral Risk Factor Surveillance System data. Data were analyzed between 2019 and 2020.

Results

A total of 5,493 and 3,764 subjects in 2011 and 2017, respectively were included. BMI (overweight/obesity) remained the most prevalent CVD risk factor. The second most common CVD risk factor was high cholesterol, followed by hypertension. Compared to females, males were 1.64 times more likely to have reported CVD in 2011, which increased to 1.92 in 2017. Compared to non-smokers, everyday smokers were 1.96 times more likely in 2011 and 3.62 times more likely in 2017. Individuals with high cholesterol status were 2.67 times more likely to have reported CVD compared to those with normal levels in 2011. In 2011, individuals with hypertension were 3.74 times more likely to have reported CVD compared to those who did not have hypertension. This relationship increased its magnitude of risk to 6.18 times more likely in 2017. In 2011, individuals with diabetes were 2.90 times more likely to have reported CVD compared to those without the condition.

Conclusions

Public health and healthcare providers need to target preventable cardiovascular risk factors and develop recommendations and strategies locally, nationally, and globally.
Maternal effects on reproduction in the precocial European hare (Lepus europaeus)
Authors: Schai-Braun Stéphanie C. , Steiger Peter , Ruf Thomas , Arnold Walter , Hackländer Klaus
Published: February 2021

In female mammals, reproduction, and in particular lactation, is the energetically most exigent life-history phase. Reproduction is strongly controlled by body reserves and food availability, so females with better body condition or food supply are believed to have higher reproductive output. Additionally, the growth and mortality of young mammals depends on their postnatal development. Therefore, the degree of precociality affects energetic demands for both mothers and young. To study the reproductive performance of the precocial European hare (Lepus europaeus), we analysed relationships between six predictor variables describing maternal and environmental effects and nine response variables relating to reproduction from 217 captive females. We compared the data with those of precocial and altricial mammal species from an extensive literature search. For hares, we found: (1) Heavier females had heavier litters at birth. (2) In summer and spring, total litter mass was larger than in winter. (3) At the end of lactation, the litters of multiparous females were heavier than those of primiparous females. (4) Both older females and females giving birth for the first time had relatively high leveret mortality during lactation. Comparing our results with the literature for other mammals revealed that the body condition (i.e., body mass) of females before birth is predictive of reproductive parameters in both precocial and altricial species. In the precocial hare, female body condition is no longer predictive of reproductive parameters at the end of lactation, whereas in altricial species, female body condition remains predictive of reproduction (litter mass at the end of lactation, offspring mortality) until the end of lactation. We conclude that these effects are caused by precocial offspring feeding on solid food soon after birth and, thus, being less dependent on the mother’s body condition during lactation than altricial offspring. In line with this, precociality might have evolved as a way of buffering offspring against maternal effects.
Marek’s disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis
Authors: Liao Yifei , Lupiani Blanca , AI-Mahmood Mohammad , Reddy Sanjay M.
Published: February 2021

Marek’s disease virus (MDV) is a potent oncogenic alphaherpesvirus that elicits a rapid onset of malignant T-cell lymphomas in chickens. Three MDV types, including GaHV-2 (MDV-1), GaHV-3 (MDV-2) and MeHV-1 (HVT), have been identified and all encode a US3 protein kinase. MDV-1 US3 is important for efficient virus growth in vitro. To study the role of US3 in MDV replication and pathogenicity, we generated an MDV-1 US3-null virus and chimeric viruses by replacing MDV-1 US3 with MDV-2 or HVT US3. Using MD as a natural virus-host model, we showed that both MDV-2 and HVT US3 partially rescued the growth deficiency of MDV-1 US3-null virus. In addition, deletion of MDV-1 US3 attenuated the virus resulting in higher survival rate and lower MDV specific tumor incidence, which could be partially compensated by MDV-2 and HVT US3. We also identified chicken histone deacetylase 1 (chHDAC1) as a common US3 substrate for all three MDV types while only US3 of MDV-1 and MDV-2 phosphorylate chHDAC2. We further determined that US3 of MDV-1 and HVT phosphorylate chHDAC1 at serine 406 (S406), while MDV-2 US3 phosphorylates S406, S410, and S415. In addition, MDV-1 US3 phosphorylates chHDAC2 at S407, while MDV-2 US3 targets S407 and S411. Furthermore, biochemical studies show that MDV US3 mediated phosphorylation of chHDAC1 and 2 affect their stability, transcriptional regulation activity, and interaction network. Using a class I HDAC specific inhibitor, we showed that MDV US3 mediated phosphorylation of chHDAC1 and 2 is involved in regulation of virus replication. Overall, we identified novel substrates for MDV US3 and characterized the role of MDV US3 in MDV pathogenesis.
The Life and Times of Malcolm McLaren, Paul Gorman (2020)
Authors: Anderson James F.
Published: February 2021

Review of: The Life and Times of Malcolm McLaren, Paul Gorman (2020)

London: Constable, 855 pp.,

ISBN 978-1-47212-109-7, h/bk, £25
What Is Post-punk? Genre and Identity in Avant-garde Popular Music, 1977-82, Mimi Haddon (2020)
Authors: Lonkin Claudia
Published: February 2021

Review of: What Is Post-punk? Genre and Identity in Avant-garde Popular Music, 1977-82, Mimi Haddon (2020)

Ann Arbor, MI: University of Michigan Press, 226 pp.,

ISBN 978-0-47212-655-2, h/bk, $70
Too Old to Die Young: Paranoid Visions, Punk Rock, and Me, Peter Jones (2020)
Authors: Murphy Michael Mary
Published: February 2021

Review of: Too Old to Die Young: Paranoid Visions, Punk Rock, and Me, Peter Jones (2020)

Dublin: Rotator PM, 295 pp.,

ISBN 978-0-99554-751-3, p/bk, €22
Killer Tunes and Screaming Bloody Murder in the Basement of Hell… and Other Stories, Cubesville (2020)
Authors: Bull Gregory
Published: February 2021

Review of: Killer Tunes and Screaming Bloody Murder in the Basement of Hell… and Other Stories, Cubesville (2020)

Manchester: Cubesville Press, 124 pp.,

ISBN 978-1-83808-350-2, p/bk, £4.97
Shellshock Rock: Alternative Blasts from Northern Ireland 1977–1984, 3CD and DVD box set, Various Artists
Authors: Bestley Russ
Published: February 2021

Review of: Shellshock Rock: Alternative Blasts from Northern Ireland 1977–1984, 3CD and DVD box set, Various Artists

London: Cherry Red, £24.99
(Auto)narrativas: hacia la construcción de un canon alternativo en italiano
Authors: Velázquez García Sara , Núñez García Laureano
Published: February 2021

¿Qué pasa cuando la historia deja de entenderse como una estructura circular estática y pasa a aceptar los reflejos, aires y nuevas realidades que se facilitan al abrir ventanas y reconocer que la narración – y quiénes narran – pueden ser diferentes? Este es el punto de partida de este volumen conjunto que pretende construir alternativas y horadar pasajes que construyan un paisaje literario que se abra a comprender la historia de manera dinámica y polifónica. Este libro se estructura en dos partes que funcionan como una manera de desestabilizar el canon literario, con el objetivo de construir un canon alternativo en lengua italiana que, en el futuro, se complemente y se funda con el impuesto y estudiado jerárquicamente desde la concepción de la historia.
A vállalatok nemzetköziesedésének dinamikája – egy kutatási modell (Dynamics of firm internationalization – a research model)
Authors: Incze Emma
Published: February 2021

A tanulmány a nemzetköziesedés elméleti modelljeinek hiányosságaival szembesülve amellett érvel, hogy ahhoz, hogy megértsük a nemzetköziesedés időben zajló folyamatát, a vállalatok nemzetközi evolúcióját a kontextussal összefüggésben kell vizsgálni. A tanulmány a vállalatok nemzetköziesedésének folyamatát vizsgáló elméleti szakirodalomra építve egy olyan kutatási modellt vázol fel, amely alkalmas lehet a nemzetköziesedés dinamikájának empirikus vizsgálatához. A modell a belépés, diverzitás, ütem és szakasz koncepciók mentén operacionalizált nemzetköziesedés mintázata és a kontextus (környezet, vállalat, menedzsment) közötti kapcsolatot teremti meg. A vázolt kutatási modell empirikus alkalmazásával lehetővé válik a nemzetközivé válás folyamata során kialakuló komplex kapcsolatrendszer feltárása és megértése. ________ Addressing some of the limitations of the theoretical models of firm internationalization this paper argues that in order to understand the process of firm internationalization along time one should observe firms and their contextual environments as complex interacting processes. Drawing on the theoretical models of firm internationalization process this study proposes a research model that may be suitable for the empirical examination of the dynamics of internationalization. The proposed model builds a relationship between the pattern of firm internationalization operationalized via concepts such as entry, diversity, pace, phases and the context (environment, firm, management) of it. By analyzing the interaction between the multi-level processes that shape internationalization, one can explore the reasons behind the dynamic profile of firm internationalization.
Etika és emberierőforrás-menedzsment: egy régi/új kapcsolat?
Authors: Csillag Sára
Published: February 2021

Az emberierőforrás-menedzsment és a gazdaságetika kapcsolatának gyökerei mélyre nyúlnak: a két terület összekapcsolódása igazából az utóbbi 15 évben kezdett önálló területté formálódni, és legalábbis kis mértékben az érdeklődés fókuszába kerülni. A szerző tanulmányában először összefoglalja azokat a fő impulzusokat, amelyek következtében az emberierőforrás-menedzsment etika iránt megélénkült az érdeklődés napjainkban, majd bemutat néhány olyan elemzési szintet és hozzá köthető vizsgálatot, amely azt a témát járja körül, hogy mikor és mitől etikus vagy etikátlan az emberierőforrás-menedzsment.
Mit nyújt a jelentésadás perspektívája a munka jelentésének kutatásában?
Authors: Szőts-Kováts Klaudia
Published: February 2021

A szerző tanulmányában áttekinti a jelentésadás témakörben a munka jelentése szempontjából általa relevánsnak tekintett szervezetelméleti, illetve menedzsmentkutatásokat, és egy példával illusztrálja a jelentésadás folyamatát. Az eset segítségével megmutatja, hogy a jelentésadás vizsgálatával rávilágíthatunk a jelentés és a munkáról alkotott kép változására. Meggyőződése, hogy a jelentésadás vizsgálata a munka jelentése kutatásának egy új perspektíváját nyújtja, ami új vizsgálati eredményekkel gazdagíthatja a munka jelentésének szakirodalmát.
Hazai nagyvállalati etikai kódexek tartalmi elemzése
Authors: Szegedi Krisztina
Published: February 2021

Az etikai kódexek az etikai értékek, normák, alapelvek, magatartási szabályok írásba foglalását jelentik, és hozzájárulnak annak tisztázásához, hogy a vállalatok üzleti hétköznapjaiban mit tekintenek legitimnek és felelősségteljesnek. A cikk az etikai kódexek szerepének szakirodalmi áttekintése után az 50 legnagyobb árbevételű hazai cég közül azok etikai kódexét vizsgálja, amelyek magyar nyelvű etikai kódexe az interneten elérhető. A tartalmi összehasonlítás kiterjed a magyar és az amerikai gyakorlatra is. Az elemzés gondolatébresztőként szolgálhat az etika intézményesítését tervező vállalatok számára.
EPP0630: Trends in Involuntary Admissions for Observation in Malta
Authors: Zammit Martha Anne , Agius Matthew Mark , Cutajar Jake , Micallef Trigona Beppe
Published: February 2021

Introduction

Schedule II of the 2013 Mental Health Act is part of the legal framework for involuntary admission to a licensed mental healthcare facility in Malta (Mount Carmel Hospital) for observation.

Objectives

To identify trends in presenting features cited by registered specialists in psychiatry in Schedule II applications as well as impact of time of day on involuntary admission.

Methods

Schedule II forms relating to all involuntary admissions to Mount Carmel Hospital between 01 June 2018 and 01 June 2019 were retrieved from paper files (n=364). Details relating to reason for using this legal framework were recorded and processed through custom linguistic analysis. Timings of application were also assessed. Data Protection permissions to retrospectively access patient files were obtained. All data collected was de-identified at source.

Results

The commonest reason for use of Schedule II was psychosis (n=139). Substance abuse was recorded in 68 cases, with alcohol and cannabinoids the commonest substances cited. 155 instances relate to situations of increased risk, the commonest being aggressive behaviour (n=74). 61 cases recorded suicidal intent. Peak use of this schedule occurs between 17:00 and 18:00, which is outside normal working hours.

Conclusions

Predominance of psychosis as a reason for involuntary admission concurs with trends reported internationally, including recent German, Irish and Dutch reports, as does increased use of involuntary admission with out-of-hours presentations. Practices relating to involuntary admission to a mental healthcare facility in Malta appear to reflect general trends in other European cohorts, despite differing legal frameworks.
Ayuda psicológica a cuidadores en diferentes escenarios.
Authors: ANDRÉS LOSADA , CELIA NOGALES-GONZÁLEZ , JAVIER LÓPEZ , MARÍA MÁRQUEZ-GONZÁLEZ , ESTEFANÍA JIMÉNEZ-GONZÁLEZ
Published: February 2021

El cuidado familiar de una persona con demencia se asocia con importantes consecuencias negativas para la salud psicológica y física de los cuidadores. Si bien se ha utilizado el término “carrera” como metáfora que permite describir las diferentes etapas por la que suelen pasar las personas que cuidan, la realidad es que no es frecuente en la literatura científica que se realice una distinción sobre intervenciones específicas para las diferentes condiciones contextuales o situacionales en las que se encuentra un cuidador. En el presente trabajo se lleva a cabo un análisis de intervenciones específicas que pueden ayudar a los cuidadores en diferentes escenarios. Específicamente, se revisan intervenciones para entrenar a los cuidadores en habilidades para el cuidado y el autocuidado, intervenciones con cuidadores que faciliten y optimicen el uso de centros de día, intervenciones para familias que se encuentren en el proceso de institucionalización del familiar en contextos residenciales y, finalmente, se revisan las posibilidades de actuación psicológica para el afrontamiento del duelo de los cuidadores. Dado el importante número de cuidadores que hay (y habrá) en nuestro país, que contrasta con la escasez de recursos disponibles para cuidadores, parece importante destinar importantes esfuerzos y recursos al desarrollo, evaluación e implantación de intervenciones para cuidadores en los diferentes contextos en los que estos se pueden beneficiar de las mismas.
Well-rounded graduates – what languages can do
Authors: Pulker Hélène , Stickler Ursula , Vialleton Elodie
Published: February 2021

The School of Languages and Applied Linguistics at the Open University
(OU) radically re-designed its modern languages curriculum in 2014,
launching its first suite of new modules in 2017. The institution as a whole
has since also developed a new employability framework. Our paper describes
the principles underpinning the design of the new curriculum, demonstrates
how it is being implemented, and focuses on an initiative that involved our
Associate Lecturers (ALs) in defining a 'well-rounded graduate' and
reflecting on plurilingualism and their roles as language teachers in a
distance-teaching institution. Presenting our Teaching Excellence project,
its processes, and findings in this paper will allow colleagues who teach
modern languages to replicate or adapt parts of our approach in their own
settings, exemplifying to the wider world how language skills can become an
inherent element of the well-rounded graduate in the 21st century.
Reflections on the impact of COVID-19 on teaching and learning in the
Faculty of Arts at the University of Nottingham
Authors: Goria Cecilia
Published: February 2021

It is widely believed that digitally-driven changes are not welcomed
amongst academic staff in higher education. However, when in March 2020, the
University of Nottingham went online in response to the UK government’s
COVID-19 lockdown, a different picture started to emerge. This contribution
reflects on the initial steps taken to respond to the COVID-19 emergency
measures, including the support required to implement these steps and
ensuing staff feedback. It also reflects on the process of moving forward
from a state of emergency to a more thought-through digital pedagogical
approach. In this scenario, the ultimate goal of this reflection is to argue
that, as a consequence of the educational turbulence caused by COVID-19, the
portrait of academics prone to resisting digitally-driven changes needs to
be replaced by one that emphasises the significance of making the
pedagogical values of these changes meaningful to the staff who eventually
implement them.
Locked down, but not isolated: Twitter collaboration among teachers in
response to COVID-19
Authors: Rosell-Aguilar Fernando
Published: February 2021

This piece looks at the use of Twitter to share good practice among
education professionals responding to the so-called ‘pivot online’: the
sudden shift to online learning necessitated by the spread of the
Coronavirus pandemic. It presents a general overview on how Twitter provided
a source of advice, ideas, and resources and how teachers shared their
expertise at this time of need, focusing on my own experience as a Twitter
user and online pedagogy expert.
How to flip it… never again? Towards agile models of work
Authors: Sadoux Marion
Published: February 2021

This paper explores the way in which the Modern Languages team at the
Oxford University Language Centre (OULC) sought to embrace the challenges of
switching to a remote mode of teaching in the third term of 2019-20 as an
opportunity to develop new ways of designing and delivering language courses
for a flexible and hybrid future. It seeks to make note of agile
recommendations towards further challenges to come.
Moving the year abroad online: ready, steady, go!
Authors: Cunico Sonia
Published: February 2021

Exeter students who had their 2019-2020 Year Abroad (YA) cut short by
the COVID-19 health crisis were offered alternative online language
provision to support their learning. This contribution discusses the
students and staff’s experience in the light of ‘learning is a journey’
metaphor.
Exploring the pandemic through language learning and multicultural
studies
Authors: Caspar Stephan
Published: February 2021

This piece offers a reflection on how language learning and
multicultural studies during the pandemic have highlighted the potential to
help communities draw parallels with, and face wider issues concerning,
minorities within a challenged society. Through storytelling, a novel
approach to teaching and learning helps students find their voice and become
active agents of change. A review of teaching and learning methods may bring
about improvements both in academia and individual circumstances to help
bridge the gap between loneliness and the need to be part of a wider social
community. This article reiterates the importance of language learning,
cultural understanding, and identity as useful employability skills for the
new global graduates to support, rebuild, and unite communities especially
in challenging times.
PENGARUH PENATAAN PERMUKIMAN KUMUH UNTUK MENCAPAI LIVABLE SETTLEMENT DI KELURAHAN TAMBAKREJO KOTA SEMARANG
Authors: Gultom Leylita Hariaty , Sunarti Sunarti
Published: February 2021

Limited ability of society both economically and managing space cause slum condition in Tambakrejo Urban Village. In the year 2015-2017 then done slum arrangement, but not yet reached livable settlement as environment condition which still not support based on condition and perception of society. Many found garbage that pollute the community environment. The purpose of this research is to know the effect of settlement arrangement to reach livable settlement in Tambakrejo Urban Village Semarang. The research method used in the form of quantitative approach, with descriptive analysis tool, likert scale and simple linear regression. Based on the research, founds that slum regulation in Tambakrejo Village has not reached livable, from 3 components that must be realized it only affect 2 aspects that is physical and social, while the economic aspect is still not influenced by the arrangement. Furthermore, people's assessment of 17 criteria of human settlement as convenience parameters, obtained 6 criteria influenced, among others, ease of access, satisfaction of infrastructure, infrastructure support activities, small home improvement costs, the role of socializing institutions, and guaranteed cooperation of government, private, and community.
El análisis jurídico y económico institucional
Authors: León Quiroga Luis Fernando
Published: February 2021

El análisis de fenómenos sociales se realiza desde diferentes perspectivas: el derecho, la economía, la sociología, la política, la psicología, entre otras disciplinas. Cada una, con una metodología o forma de aproximación más o menos diferenciada para aprehender alguna de sus dimensiones. El propósito de este proyecto es evaluar la conveniencia de adoptar una aproximación interdisciplinaria de economía y derecho, con un enfoque neoinstitucionalista, para analizar un fenómeno social complejo. Con todo, busco justificar la implementación del análisis jurídico y económico (AJE) en lugar del análisis económico del derecho (AED). La diferencia principal yace en que el AED es una disciplina aplicada propiamente desde la economía y el AJE comprende la implementación paritaria de estas dos disciplinas con menor rigurosidad, pero mayor alcance. Para avanzar en esta proposición, se abordará brevemente la noción de propiedad a partir de las herramientas del análisis institucional y de la teoría jurídica moderna de sistemas. Como resultado, fue posible hacer un esquema comprensivo de las diferentes dimensiones de la propiedad en la ciencia económica y la ciencia jurídica, y así justificar el uso del análisis jurídico y económico.
El recordatorio a la determinación del contenido esencial de los derechos fundamentales atendiendo el escenario de la pandemia por el COVID 19, en el Estado Colombiano
Authors: Blanco Alvarado Carolina
Published: February 2021

Este manuscrito pretende una aproximación global al contenido esencial de los derechos fundamentales,como prestaciones positivas y negativas que debe garantizar el Estado. Si bien la doctrina ha gestionadoteorías que explican a dicha institución como límite a la actividad legislativa, no existe explicaciónunívoca de lo que significa el contenido esencial de los derechos fundamentales: se considera que esla misma dignidad humana. Los objetivos del presente manuscrito se circunscriben a identificar ladogmática jurídica en el marco del contenido esencial de los derechos fundamentales, a establecercríticas a la referenciada dogmática jurídica y a determinar una aproximación al contenido esencial delos derechos fundamentales. La metodología de investigación empleada en el manuscrito es de caráctercualitativo, en razón a que el problema de investigación planteado supuso analizar descriptivamentela naturaleza jurídica del contenido esencial de los derechos fundamentales. Lo anterior, desde elmétodo de investigación descriptivo-documental, ya que el artículo se fundamentó en la doctrinaexistente sobre el tema en particular.

ativo en razón a que el problema de investigación planteado supuso analizar descriptivamente la naturaleza jurídica del contenido esencial de los derechos fundamentales. Lo anterior desde el método de investigación descriptivo - documental, ya que el artículo se fundamentó en la doctrina existente sobre el tema en particular
Die Prinzipien der katholischen biblischen Hermeneutik in „der Sprache der Unmündigen“. Ein Beitrag zum 25. Jubiläum des Dokumentes der Päpstlichen Bibelkommission zur Interpretation der Bibel in der Kirche
Authors: Dzikiewicz Daniel
Published: February 2021

Ponad 25 lat temu Papieska Komisja Biblijna wydaa dokument pod tytuem „Interpretacja Pisma witego w Kociele”. Zosta on powicony ówczesnym naukowym kwestiom hermeneutyczno- egzegetycznym. Niemniej jednak duszpasterska strona tego zagadnienia nie zostaa pominita. Duszpasterze powinni take w dostpny sposób przyblia Pismo wite wszystkim wiernym (rozdz. IV, art. C, nr 3). Ale jak to zrealizowa praktycznie? Dokument nie rozwija szczegóowo tego tematu. Niniejszy artyku podejmuje dane wezwanie, przedstawiajc gówne hermeneutyczno- -biblijne zasady Kocioa Katolickiego „jzykiem prostaczków” (Mt 11,25).
Teologia jako nauka sui generis. W kontekście teologii ks. Franciszka Dziaska
Authors: Kotkowska Elżbieta
Published: February 2021

Rev. Franciszek Dziasek, S.Th.D. was a lecturer of the Archbishop’s Seminary in Poznan from 1950 to 1964. In his lectures, Introduction to Theological Sciences, step by step he justifies claims of theology to be science in the university sense. From the reception of his lectures we learn that he was living with what he preached. In the integral view of the two realities, [theologian and his knowledge] we are shown a trait of theology wisdom, which shows its specificity as the queen of sciences. A Poznan lecturer argues that theology is a science in the ordinary sense of the word. It is also the science of sui generis, because it derives its data from a revelation that is credible in the community of the Church.
El transporte aéreo como indicador para medir la sustentabilidad turística: El caso de Cancún en Quintana Roo
Authors: Fresneda Edel J , Valenzuela-Muñiz Ana María
Published: February 2021

En este artículo se analizan las emisiones de CO2 producidas por el transporte aéreo de pasajeros en un destino turístico con una alta dependencia a estos vuelos. Este indicador se asume como sustantivo para medir, en condiciones similares de desenvolvimiento, a) el alcance ecológico de este tipo de desarrollo al nivel regional y b) la sustentabilidad a nivel local. Con este propósito, se analizan los vuelos nacionales e internacionales realizados hacia y desde Cancún en el periodo 2014-2016. Así, la discusión versa sobre cómo la dependencia de este destino turístico hacia el transporte aéreo de pasajeros para satisfacer la oferta turística, que en el caso específico de análisis ha tenido un incremento en la frecuencia y distancia total de los vuelos, está provocando altos niveles de emisión de CO2, con un posible impacto medioambiental relevante en la degradación de ecosistemas vecinos y en el ámbito internacional.
Bushat, not lost but found: a ‘new’ Illyrian settlement in northern Albania
Authors: Lemke Martin , Shpuza Saimir , Wojciechowski Bartosz
Published: February 2021

Investigations at Bushat in northern Albania during 2017–2019 have brought to light a massive fortification wall dating to the fourth century BC and enclosing approximately 20ha of hilly terrain. The wall is connected to the development of Illyrian settlements and the Hellenisation of the area.
On the Use of the areaΔ and the Three-Parameter Model to Estimate High Cycle Fatigue Life
Authors: Ding Mingchao , Zhang Yuanliang , Lu Huitian
Published: February 2021

In our previous work, a parameter areaΔ was proposed to describe fatigue damage caused by micro scratch, whose validity was verified by fracture mechanics. In this article, we summarize an attempt to check the applicability of the areaΔ in the field of the classic S-N curve method. For the sake of objective verification, the experiment data used in this article are from our published work. A high cycle fatigue life model of TC17 based on micro scratches is established with the synthesis of the three-parameter model and Murakami equation modified by areaΔ. Prediction results gave accuracy to mainly fall into the scatter band of factor 2. It can be suggested that areaΔ is suitable for being used in both fracture mechanics and classic S-N curve method. Furthermore, the validity of areaΔ in fatigue behavior analysis combined with current fatigue theories and materials is summarized. The measurement method of scratch depth and width suitable for areaΔ is also introduced.
American Indian Soundchiefs
Authors: Garrett-Davis Josh
Published: February 2021

American Indian Soundchiefs, an independent record label founded by the Rev. Linn Pauahty (Kiowa) in the 1940s, developed a remarkable model of Indigenous sound media that combined home recording, dubbing, and small-scale mass production. Alongside other Native American media producers of the same era, Soundchiefs built on earlier engagements with ethnographic and commercial recording to produce Native citizens’ media a generation prior to the Red Power era of the 1960s and 1970s. This soundwork provided Native music to Native listeners first, while also seeking to preserve a “rich store of folk-lore” sometimes in danger of being lost under ongoing colonial pressures. Pauahty’s label found ways to market commercial recordings while operating within what music and legal scholar Trevor Reed (Hopi) calls “Indigenous sonic networks,” fields of obligation and responsibility.
“Black Soundwork, Knowledge Production, and the “Debate” Over Tap Dance Origins”
Authors: Thomas Sonja
Published: February 2021

In this commentary, I examine tap dance as Black soundwork and antiracist activism. Tracing a controversy over the supposed Irish contributions to tap dance’s early history, I question why non-Black practitioners rely on academic knowledge production, especially when Black soundwork is not just marginalized in the academy, but often controlled and rewritten to adhere to white standards. I argue that non-Black peoples need to understand the ways in which origins perform political work, and to critically examine the ways in which correcting origins is only the first step to dismantling systemic racism.
After Words: On Octavia Butler's “Speech Sounds”
Authors: Gale Nikita
Published: February 2021

In this essay, artist Nikita Gale presents a reading of Octavia Butler’s short story Speech Sounds through the work of Edouard Glissant, Kate Lacey, Homi Bhabha, and Elaine Scarry. Gale considers the trauma of silence and the loss of language as events that might serve as starting points for emergent forms of social relations.