bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Testing of the Relational and Structural Components of Innovativeness Across Academia and Practice for Healthcare Progress Scale
Authors: Joseph M. Lindell , Williams Michele , Reinke Karl , Bair Heather , Chae Sena , Hanrahan Kirsten , St. Marie Barbara , Jenkins Peggy , Albert Nancy M. , Gullatte Mary M. , Rogers Darlene M. , Swan Beth Ann , Holden Tina , Woods Elizabeth , DeGuzman Pamela B. , DeGennaro Gina , Marshall David , Hein Maria , Perkhounkova Yelena , Huber Diane L.
Published: April 2024

OBJECTIVE

Using data from 5 academic-practice sites across the United States, researchers developed and validated a scale to measure conditions that enable healthcare innovations.

BACKGROUND

Academic-practice partnerships are a catalyst for innovation and healthcare development. However, limited theoretically grounded evidence exists to provide strategic direction for healthcare innovation across practice and academia.

METHODS

Phase 1 of the analytical strategy involved scale development using 16 subject matter experts. Phase 2 involved pilot testing the scale.

RESULTS

The final Innovativeness Across Academia and Practice for Healthcare Progress Scale (IA-APHPS) consisted of 7 domains: 3 relational domains, 2 structural domains, and 2 impact domains. The confirmatory factor analysis model fits well with a comparative fit index of 0.92 and a root-mean-square error of approximation of 0.06 (n = 477).

CONCLUSION

As the 1st validated scale of healthcare innovation, the IA-APHPS allows nurses to use a diagnostic tool to facilitate innovative processes and outputs across academic-practice partnerships.
Uterine Inflammatory Myofibroblastic Tumors
Authors: Devins Kyle M. , Ordulu Zehra , Mendoza Rachelle P. , Croce Sabrina , Haridas Rishikesh , Wanjari Pankhuri , Pinto Andre , Oliva Esther , Bennett Jennifer A.
Published: April 2024

Uterine inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms of uncertain malignant potential. Aside from the recently described risk stratification score, which has not been validated by other studies, and rare reports of aberrant p16 expression in malignant tumors, there are no criteria to reliably predict behavior. Herein, we evaluated the clinicopathologic features and p16 expression patterns in 30 IMTs, with genomic profiling performed in a subset (13 malignant, 3 benign). Fifteen patients had malignant IMTs, defined by extrauterine disease at diagnosis (n=5) or recurrence (n=10; median: 24 mo). Patients ranged from 8 to 65 (median: 51) years and tumors from 6 to 22 (median: 12.5) cm. In primary tumors (n=13), infiltrative borders were noted in 10, moderate/severe cytologic atypia in 9, tumor cell necrosis in 7, and lymphovascular invasion in 6, while mitoses ranged from 0 to 21 (median: 7) per 10 high-power fields. In contrast, 15 patients with benign IMTs ranged from 28 to 65 (median: 44) years, with follow-up of 18 to 114 (median: 41) months. Tumors ranged from 1.9 to 8.5 (median: 5.5) cm, 2 demonstrated infiltrative borders, and 1 had moderate cytologic atypia. No other high-risk histologic features were observed. Application of the previously described clinicopathologic risk stratification score in all primary IMTs with complete data (n=18) classified 8 as high-risk (all malignant), 8 as intermediate-risk (3 malignant, 5 benign), and 2 as low-risk (benign). p16 was aberrant in all malignant IMTs, with <1% expression noted in 10, overexpression (>90%) in 4, and subclonal loss in 1; all benign tumors had patchy staining (20% to 80%; median 50%). Molecular analysis detectedCDKN2Adeletions in 8 of 9 tumors with <1% p16 expression, while the other harboreda TERTpromoter mutation.TERTpromoter mutations were also identified in 2 of 3 IMTs with p16 overexpression. Neither of these alterations was detected in the 3 sequenced benign IMTs. Thus, we recommend performing p16 on all uterine IMTs, which, combined with the risk stratification score, is a promising and cost-effective tool for predictingCDKN2Astatus and outcome in these patients. It may be particularly useful for tumors with incomplete information for risk stratification (ie, morcellated tumors) and for further stratifying intermediate-risk IMTs when sequencing is unavailable.
Which Sit-to-Stand Test Best Differentiates Functional Capacity in Older People?
Authors: Cruz-Montecinos Carlos , Torres-Castro Rodrigo , Otto-Yáñez Matías , Barros-Poblete Marisol , Valencia Carola , Campos Alex , Jadue Leticia , Barros Marcela , Solis-Navarro Lilian , Resqueti Vanessa
Published: April 2024

The sit-to-stand test provides insight into age-related functional capacity; however, there are various variants of sit-to-stand, and we do not know which of these better discriminates against age-related functional capacity. Our study aimed to compare the age-related functional capacity in older people by evaluating sit-to-stand power variants, using young individuals as a reference. A cross-sectional study was conducted in 102 adults (57 women) aged 60–80 and 105 adults (54 women) aged 20–30. Participants performed five times sit-to-stand (5 sit-to-stand), 30-second sit-to-stand, and 1-min sit-to-stand. Z scores were obtained for each sit-to-stand variant using power (W), relative (W/kg), and allometric (W/m2) normalization methods. A mixed repeated-measures analysis of variance assessed the interactions among the sit-to-stand variants, normalization methods, sex, physical activity, and tobacco history. A significant interaction between sit-to-stand variants, normalization methods, and sex (P = 0.002) was found. The mean effect of sit-to-stand variants revealed that the 1-min sit-to-stand had the lowest Z score (P < 0.05). Significant variations were observed between sit-to-stand variants in all normalization methods for women (P < 0.001). However, in men, only the difference between 5 sit-to-stand and 1-min sit-to-stand remained consistent across normalization methods (P < 0.05). Our findings highlight the efficacy of 1-min sit-to-stand in distinguishing age-related functional capacity over the other sit-to-stand tests, especially in women.
Radionuclide Therapy With 177Lu-PSMA in a Patient With Hepatocellular Carcinoma
Authors: Pretet Valentin , Giraudet Anne Laure , Vergnaud Laure , Paquet Emilie , Kryza David
Published: April 2024

A 69-year-old man diagnosed with progressive bone metastatic castration-resistant prostate adenocarcinoma and concurrent alcoholic cirrhosis with multiple hepatocellular carcinoma (HCC) nodules was referred to our nuclear medicine service for 177Lu-PSMA-617 therapy. The patient’s pretreatment screening using 68Ga-PSMA-11 PET/CT revealed high prostate-specific membrane antigen expression in both prostatic and HCC lesions. The patient underwent 2 doses of 177Lu-PSMA-617. Subsequent imaging assessments with 68Ga-PSMA-11 PET/CT and hepatic MRI indicated progressive HCC nodules, while showing a partial response in prostatic bone metastases. Positive clinical and biological responses were observed only in prostatic disease, but not in HCC nodules.
Lentzea sokolovensis sp. nov., Lentzea kristufekii sp. nov. and Lentzea miocenica sp. nov., rare actinobacteria from Miocene lacustrine sediment of the Sokolov Coal Basin, Czech Republic
Authors: Lara Ana Catalina , Kotrbová Lucie , Keller Moritz , Nouioui Imen , Neumann-Schaal Meina , Mast Yvonne , Chroňáková Alica
Published: April 2024

The taxonomic position of three actinobacterial strains, BCCO 10_0061T, BCCO 10_0798T, and BCCO 10_0856T, recovered from bare soil in the Sokolov Coal Basin, Czech Republic, was established using a polyphasic approach. The multilocus sequence analysis based on 100 single-copy genes positioned BCCO 10_0061T in the same cluster as Lentzea waywayandensis, strain BCCO 10_0798T in the same cluster as Lentzea flaviverrucosa, Lentzea californiensis, Lentzea violacea, and Lentzea albidocapillata, and strain BCCO 10_0856T clustered together with Lentzea kentuckyensis and Lentzea alba. Morphological and chemotaxonomic characteristics of these strains support their assignment to the genus Lentzea. In all three strains, MK-9(H4) accounted for more than 80 % of the isoprenoid quinone. The diagnostic diamino acid in the cell-wall peptidoglycan was meso-diaminopimelic acid. The whole-cell sugars were rhamnose, ribose, mannose, glucose, and galactose. The major fatty acids (>10 %) were iso-C15 : 0, anteiso-C15 : 0, iso-C16 : 0, and C16 : 0. The polar lipids were diphosphatidylglycerol, methyl-phosphatidylethanolamine, phosphatidylethanolamine, hydroxy-phosphatidylethanolamine, phosphatidylglycerol, and phosphatidylinositol. The genomic DNA G+C content of strains (mol%) was 68.8 for BCCO 10_0061T, 69.2 for BCCO 10_0798T, and 68.5 for BCCO 10_0856T. The combination of digital DNA–DNA hybridization results, average nucleotide identity values and phenotypic characteristics of BCCO 10_0061T, BCCO 10_0798T, and BCCO 10_0856T distinguishes them from their closely related strains. Bioinformatic analysis of the genome sequences of the strains revealed several biosynthetic gene clusters (BGCs) with identities >50 % to already known clusters, including BGCs for geosmin, coelichelin, ε-poly-l-lysine, and erythromycin-like BGCs. Most of the identified BGCs showed low similarity to known BGCs (<50 %) suggesting their genetic potential for the biosynthesis of novel secondary metabolites. Based on the above results, each strain represents a novel species of the genus Lentzea, for which we propose the name Lentzea sokolovensis sp. nov. for BCCO 10_0061T (=DSM 116175T), Lentzea kristufekii sp. nov. for BCCO 10_0798T (=DSM 116176T), and Lentzea miocenica sp. nov. for BCCO 10_0856T (=DSM 116177T).
Sphingobium cyanobacteriorum sp. nov., isolated from fresh water
Authors: Le Ve Van , Ko So-Ra , Kim Min-Seong , Kang Mingyeong , Jeong Seonah , Ahn Chi-Yong
Published: April 2024

A novel Gram-stain-negative, yellow-pigmented, short rod-shaped bacterial strain, HBC34T, was isolated from a freshwater sample collected from Daechung Reservoir, Republic of Korea. The results of 16S rRNA gene sequence analysis indicated that HBC34T was affiliated with the genus Sphingobium and shared the highest sequence similarity to the type strains of Sphingobium vermicomposti (98.01 %), Sphingobium psychrophilum (97.87 %) and Sphingobium rhizovicinum (97.59 %). The average nucleotide identity (ANI) and digital DNA–DNA hybridisation (dDDH) values between HBC34T and species of the genus Sphingobium with validly published names were below 84.01 and 28.1 %, respectively. These values were lower than the accepted species-delineation thresholds, supporting its recognition as representing a novel species of the genus Sphingobium. The major fatty acids (>10 % of the total fatty acids) were identified as summed feature 8 (C18 : 1ω7c and/or C18 : 1ω6c) and summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c). The main polar lipids were phosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, two phospholipids and two unidentified polar lipids. The respiratory quinone was Q-10. The genomic DNA G+C content of HBC34T was 64.04 %. The polyphasic evidence supports the classification of HBC34T as the type strain of a novel species of the genus Sphingobium, for which the name Sphingobium cyanobacteriorum sp. nov is proposed. The type strain is HBC34T (= KCTC 8002T= LMG 33140T).
Worms of change: anthropogenic disturbance changed the ectoparasite community structure of Lake Victoria cichlids
Authors: Gobbin Tiziana , Van Steenberge Maarten , Vranken Nathan , Vanhove Maarten PM
Published: April 2024

Host-parasite interactions increase the complexity, and thus robustness and resilience, of an ecosystem. This role is particularly relevant in times of global change. Environmental changes cause biodiversity loss and shifts in community compositions of free-living organisms, but how these changes affect parasite communities is still unclear. We tested how parasites respond to anthropogenic perturbations, using the case of Lake Victoria (East Africa), after 40 years of their onset. Lake Victoria experienced multiple human-induced invasions (e.g. Nile perch) and eutrophication that heavily affected haplochromine cichlid fishes (whose species richness decreased from 500 to 250 species in a decade). We compared gill macroparasite communities of 13 haplochromine species before and after perturbations, using historical and recent fish collections. The host-parasite network re-arranged, with few emerging and few disappearing host-parasite combinations, in a way that reduced stability. The host range of parasites, which is linked to resilience ability, decreased and thus we expect a decreased resilience ability in the future. We also found a decrease in infection parameters, co-infection occurrence, and biodiversity indices highlighting the urgent need of a conservation plan for wildlife parasites, to preserve their ecosystem services in face of global change. This study serves as a proof-of-concept of how often-overlooked aspects of host-parasite interactions provide a tool to monitor the health status of an ecosystem.
Harnessing the Eccrine Sweat Glands for the Management of Interdialytic Weight Gain – A Pilot Study
Authors: Armaly Zaher A. , Nitzan Yaacov , Chernin Gil , Aronson Doron
Published: April 2024

Background

Hemodialysis patients are susceptible to excess volume accumulation, particularly over the 2-day interval (long interdialytic gap), resulting in higher interdialytic weight gain (IDWG).

Methods

We employed a novel device designed to enhance fluid and salt loss by activating of the eccrine sweat glands to treat IDWG. Patients eligible for the study were undergoing regular hemodialysis for ≥3 months, without residual renal function, and with IDWG (as a percentage of IDWG/dry body weight) ≥2.5%. Treatments were administered at the patient’s home. The primary performance endpoint was differences in weight gain over long interdialytic period with the device compared to the control period. Secondary exploratory endpoints included the need for ultrafiltration (UF) rate > 10 mL/kg/h in the post-interval dialysis.

Results

Five patients were enrolled into the pilot study (age range 26 to 69 years, 3 women). The hourly mean weight loss from sweat was 186 ± 45 gr/h. The average procedure length was 4.5 hours with an average fluid loss of 899 ± 283 gr per procedure. The average least-squares mean absolute difference between the control and treatment periods was -2.0%; (95% confidence interval [CI], -2.9% to -1.2%, P<0001). The reduction in IDWG was associated a reduction in UF rates, with a least-squares mean difference of -3.2 mL/Kg/min [95% CI -4.6 to -1.8] between the control and treatment periods (P<0.001), resulting in a safe UF rate (<10 mL/Kg/min) in all post-treatment sessions.

Conclusion

Enhancing sweat rate mitigated IDWG in hemodialysis patients. Together with trice weekly HD, this therapy more closely approximates the capacity of the native kidney to regulate extracellular volume and solute composition, similar to patients with substantial residual kidney function.
The behaviors of Indonesian domestic ecotourists using a Rasch analysis
Authors: Setiawan Budi , Muawanah Umi , Maulana Addin , Khoiriyani Fauziah , Tri Astuti Marhanani , Hakim Imam Nur
Published: April 2024

Purpose

This study aims to analyze the capacity of ecotourists to exhibit behavior that aligns with the ecotourist scale using the Rasch model measurement.

Design/methodology/approach

The data was gathered using an online survey incorporating the five tenets of ecotourism using a seven-point rating scale on domestic tourists in Indonesia. Descriptive statistics, cross-tabulation and Rasch model measurement were used to analyze the data.

Findings

The ecotourist identification scale measurement items were reliable and satisfactory. The most challenging behavior for ecotourists was using the services of a tour guide who was concerned about the environment. Meanwhile, respecting cultural differences around the tourist destination was the most accessible behavior. Most respondents demonstrated a fit response pattern and satisfactorily met the validity and reliability criteria.

Research limitations/implications

This study did not compare ecotourists’ ability to behave by the type of conservation visited as its limitation. However, it provides a significant methodological contribution to developing a measurement of ecotourist behavior implemented in well-established behavioral theories.

Practical implications

Integrating ecotourism into education, incentivizing eco-friendly tourism practices, promoting awareness, supporting local businesses, respecting local values and ensuring safe travels.

Originality/value

To the best of the authors’ knowledge, this study is the first of its kind to be conducted in Indonesia. It uses a unique and innovative method to reveal the unobserved variables in ecotourists’ behavior. The findings confirm that tourists’ behaviors align with the five tenets of ecotourism.
Analysis of market environment for smart grid technology investments via facial action coding system-enhanced hybrid decision-making model
Authors: Yuksel Serhat , Dincer Hasan , Mikhaylov Alexey
Published: April 2024

Purpose

This paper aims to market analysis on the base many factors. Market analysis must be done correctly to increase the efficiency of smart grid technologies. On the other hand, it is not very possible for the company to make improvements for too many factors. The main reason for this is that businesses have constraints both financially and in terms of manpower. Therefore, a priority analysis is needed in which the most important factors affecting the effectiveness of the market analysis will be determined.

Design/methodology/approach

In this context, a new fuzzy decision-making model is generated. In this hybrid model, there are mainly two different parts. First, the indicators are weighted with quantum spherical fuzzy multi SWARA (M-SWARA) methodology. On the other side, smart grid technology investment projects are examined by quantum spherical fuzzy ELECTRE. Additionally, facial expressions of the experts are also considered in this process.

Findings

The main contribution of the study is that a new methodology with the name of M-SWARA is generated by making improvements to the classical SWARA. The findings indicate that data-driven decisions play the most critical role in the effectiveness of market environment analysis for smart technology investments. To achieve success in this process, large-scale data sets need to be collected and analyzed. In this context, if the technology is strong, this process can be sustained quickly and effectively.

Originality/value

It is also identified that personalized energy schedule with smart meters is the most essential smart grid technology investment alternative. Smart meters provide data on energy consumption in real time.
From hierarchical to matrix structure: tensions in negotiating shared leadership configurations
Authors: Gibeau Emilie
Published: April 2024

Purpose

Despite much attention being devoted to shared leadership, the negotiation of such arrangements remains underexplored. In parallel, the revival of interest in matrix structures reveals their challenges but neglects the dynamics of shared leadership. In this case study, the author analyzes the tensions experienced by senior managers of a healthcare organization transitioning from a hierarchical to matrix structure as they negotiate their leadership roles in this new arrangement.

Design/methodology/approach

The author interviewed 16 senior managers, observed their meetings and analyzed documents. These data were combined with secondary data including previous interviews and observations of this top leadership team. The author then conducted an inductive data analysis.

Findings

The author's analysis reveals that the tensions experienced by senior managers as they negotiate their roles reflect the co-existence of leadership surpluses (too much leadership) and deficits (too little leadership) in matrix organizations. The author argues that surpluses and deficits are not mutually exclusive but are interrelated and shows how leadership surpluses can create leadership deficits.

Practical implications

The author’s findings suggest that in contexts of leader abundance, actors should explore leadership voids. Particular attention should be paid to incidents of intrusion and exclusion, moments of transition and intense role negotiation, as those contexts are particularly conducive to leadership deficits.

Originality/value

While previous work on matrix structures focuses on leadership surpluses, the author discusses leadership deficits. The author explores how more leaders do not necessarily mean more leadership, but instead how more leaders may result in leadership voids.
Guidelines to promote sustainable transport in higher education universities: a bibliometric and systematic review
Authors: Oestreich Letícia , Neuenfeldt Júnior Álvaro , Ruiz-Padillo Alejandro
Published: April 2024

Purpose

Unplanned urban mobility causes negative effects on the population and the environment. This study aims to understand how higher education institutions (HEIs) are managing the transportation issues related to their activities and how they are implementing actions towards more sustainable practices in this regard.

Design/methodology/approach

A systematic review and bibliometric analysis were performed using the Proknow-C method, and the bibliographic portfolio was evaluated to answer guiding questions about distribution of articles over the years and around the world, the most relevant and frequent topics, the travel behavior of university life and the main methodologies used. The meta-analysis was modeled using a programming language in R to execute Bibliometrix package.

Findings

Sharing systems, active transport, public transport, urban planning, car parking management and travel behavior are the most relevant topics related to sustainable mobility in HEIs. Different strategies to reduce car use are adopted, and the geographic location of the university and the availability of housing and shopping services in close proximity directly influence travel patterns. As a result, seven guidelines and strategic actions associated were proposed to promote the engagement of institutions in the development of sustainable transport and guide future studies about new solutions to promote sustainable university commutes.

Originality/value

This paper presents a new perspective by performing a critical literature review based on the experiences reported by several isolated studies on the subject. Initiatives of sustainable transport guidelines can be used by academics, urban planners, higher education administrators and other stakeholders to make universities more environmentally friendly, inclusive and accessible.
The institutional e-lending setup in Scandinavian libraries: logics in play in the eyes of library and policy actors
Authors: Liguzinski Maciej , Kann-Rasmussen Nanna
Published: April 2024

Purpose

The article investigates the institutional setup of e-lending in public libraries in Denmark, Norway and Sweden. Our point of departure is that e-lending has necessitated new library collaborations between local, regional and national levels, and therefore, institutional e-lending setups have emerged. The study seeks to provide better understanding of how the institutional setups are structured, how governance logics have shaped them and what tensions and dynamics become visible in the key actors’ problematisations of these setups.

Design/methodology/approach

The study is situated in the neo-institutional tradition and applies the institutional logics perspective. The research questions are answered by taking a qualitative approach, grounded in an extensive interview study with representatives of libraries, publishers and policy actors in three Scandinavian countries. To provide in-depth insight into e-lending setups, the scope of empirical material is then limited to accounts the central library and policy actors involved in establishing e-lending.

Findings

The analysis shows that the e-lending setups are both similar (especially when it comes to financing), and different across Scandinavia, especially when it comes to centralisation and involvement of librarians in this task. The differences are attributed to the influence of different governance logics (question of administrative autonomy, collaboration in the field and existing legal and political frames), and to what extent the digital and market logics are incorporated or rejected in the field.

Originality/value

The study provides new insights into the question of how Scandinavian public libraries face the consequences of the digitalisation of book distribution and consumption by investigating how they organise their e-lending services. This has not been explored before, notably in a comparative perspective.
Business model innovation and internationalization: investigating the relationship through the dynamic states approach
Authors: Krenn Melanie Luise , Chiarvesio Maria
Published: April 2024

Purpose

This empirical paper investigates how entrepreneurial firms change their business models in the context of internationalization by identifying different forms of business model innovation (BMI) and exploring the interrelationship between BMI and internationalization.

Design/methodology/approach

Based on the dynamic states approach of entrepreneurship (Levie and Lichtenstein, 2010), this paper analyses primary and secondary data from nine European firms following a multiple case study approach.

Findings

This paper presents four patterns of radical change and eight types of incremental adaption with-in business models in the context of internationalization. We describe these BMI patterns and types, and we also show how they contribute to increasing involvement in international business activities and the internationalization-related triggers that might cause them.

Originality/value

This paper contributes to a better understanding of the BMI process in the course of internationalization. It also highlights the complex interrelationship between BMI and internationalization by building on a progressive theoretical approach.
The influences on the status of information technology governance implementations in Malaysia’s technical universities
Authors: Liew Chin Wei , Hamid Nor Aziati Abdul
Published: April 2024

Purpose

This study aims to collect empirical data and observe the type of influences that were causing impact to the implementation of information technology governance (ITG) mechanisms in Malaysia’s technical universities. This study enhanced the understanding on the status of ITG implementation and revealed internal and external influences that were shaping the types of ITG mechanisms implemented within universities and present a new perspective through the lens of resource-based view and continuous improvement.

Design/methodology/approach

This study focused on two Malaysia’s technical universities belongs under same university’s network. Five IT leaders involved in the implementations of ITG from each university were interviewed. Qualitative content analysis was used as the main analyzing method to extract categories and themes from the transcripts. Final results were produced after multiple efforts of refining categories and themes in ITG implementations.

Findings

The findings revealed that both Malaysia’s technical universities had more soundly implementations in structure mechanisms than relational and process mechanisms. The shaping of implemented mechanisms was influenced by environment surrounding the universities, internally and externally. The findings proposed that the internal and external factors are best addressed with the growth of internal ITG expertise.

Research limitations/implications

This research was conducted on two of Malaysia’s technical universities that were under a university network. Although both universities had presented the exact trend in the type of ITG mechanisms implemented in the universities, more empirical data were needed to further solidify the findings from this study. Other than that, the major respondents for this research were middle-level IT officers and leaders in the universities. Further research could be conducted specifically on top-level managements to further understand the point of views of top managements in the aspect of ITG mechanisms implementations in universities.

Originality/value

This study discussed how each factor could influence the types of ITG mechanisms implemented in Malaysia’s technical universities and concluded the attentions needed to improve the overall environment for ITG implementations in universities through the lens of resource-based view and continuous improvement.
What facilitates users’ compliance willingness to health information in online health communities: a subjective norms perspective
Authors: Feng Cuicui , Yi Ming , Hu Min , Mo Fuchuan
Published: April 2024

Purpose

The environment in which users acquire medical and health information has changed dramatically, with online health communities (OHCs) emerging as an essential means for accessing health information. It is imperative to comprehend the factors that shape the users' compliance willingness (UCW) to health information in OHCs.

Design/methodology/approach

This study adopted the information adoption model (IAM) and theory of planned behavior (TPB) to investigate the influence of argument quality (AQ), source credibility (SC) and subjective norms (SN) on UCW while considering the two types of online health information – mature and emerging treatments. The authors conducted an explanatory-predictive study based on a 2 (treatment types: mature vs. emerging) * 2 (AQ: high vs. low) * 2 (SC: high vs. low) scenario-based experiment, using the partial least squares structural equation modeling (PLS-SEM).

Findings

SC positively influences AQ. AQ, SC and SN contribute to information usefulness (IU). These factors positively affect UCW through the mediation of IU. SN were found to improve UCW directly. Moreover, the moderating effect of SC on AQ and IU was more substantial for emerging treatments.

Originality/value

The research model integrates IAM and TPB, considering information types as an additional variable. The approach and findings provide a valuable explanation for UCW to health information in OHCs.
Impacts of umbrella species management on non‐target species
Authors: Zarri Elise C. , Naugle David E. , Martin Thomas E.
Published: April 2024

Restoration of anthropogenically altered habitats has often focused on management for umbrella species—vulnerable species whose conservation is thought to benefit co‐occurring species. Woody plant encroachment is a form of habitat alteration occurring in grasslands and shrublands around the globe, driven by anthropogenic shifts in disturbance regimes. Conifer encroachment is a pervasive threat to historically widespread sagebrush communities, as trees outcompete sagebrush and can negatively affect sagebrush‐obligate animal species. Degradation and loss of sagebrush plant communities in western North America have been associated with drastic declines in wildlife populations. The imperilled Greater Sage‐Grouse is assumed to be an umbrella species for the sagebrush community, so habitat restoration, including removal of encroaching conifers, is commonly targeted towards sage‐grouse. How this conservation action affects the demography of species other than sage‐grouse is largely unknown.

We quantified the demographic effects of landscape‐level restoration of sagebrush communities through conifer removal on an assemblage of sagebrush‐obligate, shrubland generalist and woodland‐associated songbirds. We compared songbird density and reproduction between adjacent restored and uncut conifer‐encroached sagebrush plots in southwest Montana. We found and monitored nests to record nest fate and number of offspring produced.

We found demographic benefits for sagebrush‐obligate species in restored areas. Sage Thrashers colonized restored areas. Brewer's Sparrow density was 39% higher and nest success was 63% higher in removal treatments, resulting in 119% higher fledgling production compared with uncut areas. The density of Vesper Sparrows, a shrubland generalist, was 308% higher and fledgling production was 660% higher in restored areas.

Another shrubland generalist, the White‐crowned Sparrow, experienced 55% lower density and 37% lower fledgling production in conifer removal areas. Two woodland‐associated species, Chipping Sparrows and Dark‐eyed Juncos, were nearly extirpated following conifer removal. A third woodland associate, the Green‐tailed Towhee, experienced 57% lower density and 69% lower fledgling production in removal than non‐removal areas.

Synthesis and applications. Our study demonstrates the benefits of conifer removal for sagebrush‐obligate species, while highlighting species that may be sensitive. Umbrella species management can benefit co‐occurring species with similar habitat associations, but demographic analyses for all impacted species are essential for effective conservation.
Unveiling the culturable and non‐culturable actinobacterial diversity in two macroalgae species from the northern Portuguese coast
Authors: Girão Mariana , Alexandrino Diogo A. M. , Cao Weiwei , Costa Isabel , Jia Zhongjun , Carvalho Maria F.
Published: April 2024

Actinomycetota, associated with macroalgae, remains one of the least explored marine niches. The secondary metabolism of Actinomycetota, the primary microbial source of compounds relevant to biotechnology, continues to drive research into the distribution, dynamics, and metabolome of these microorganisms. In this study, we employed a combination of traditional cultivation and metagenomic analysis to investigate the diversity of Actinomycetota in two native macroalgae species from the Portuguese coast. We obtained and taxonomically identified a collection of 380 strains, which were distributed across 12 orders, 15 families, and 25 genera affiliated with the Actinomycetia class, with Streptomyces making up approximately 60% of the composition. Metagenomic results revealed the presence of Actinomycetota in both Chondrus crispus and Codium tomentosum datasets, with relative abundances of 11% and 2%, respectively. This approach identified 12 orders, 16 families, and 17 genera affiliated with Actinomycetota, with minimal overlap with the cultivation results. Acidimicrobiales emerged as the dominant actinobacterial order in both macroalgae, although no strain affiliated with this taxonomic group was successfully isolated. Our findings suggest that macroalgae represent a hotspot for Actinomycetota. The synergistic use of both culture‐dependent and independent approaches proved beneficial, enabling the identification and recovery of not only abundant but also rare taxonomic members.
The Buddy Study: Local reach, adoption and implementation following a randomised controlled trial of conservative management of fifth metacarpal neck fractures
Authors: Alexander Charlotte Mary , Purdy Eve , Reynolds Aoife , Nguyen Luc , Pellatt Richard AF , Keijzers Gerben
Published: April 2024

Objective

To understand the reach, adoption and implementation of the evidence that buddy strapping for uncomplicated fifth metacarpal neck fractures is non‐inferior to plaster casting.

Methods

Mixed‐method study using clinical audit of the years before and after the original randomised controlled study was published (2019) and staff questionnaires/semi‐structured interviews.

Results

Sixty‐nine percent of questionnaire respondents were aware of the original study findings (i.e. reach) and 57% had adopted the research findings. The proportion of patients receiving buddy strapping was 6% in 2014–2016 and 28% in 2019–2021 (implementation). Qualitative data provided insight into ongoing barriers to adoption and implementation including fear of reprisal, the need for permission, opinions of senior decision makers, perceptions about patient preferences, and an overall tendency to ‘play it safe’.

Conclusions

Even in a department where primary research is conducted, implementation requires ongoing attention to factors impacting reach and adoption.
A scoping review of Australian nutrition resources for feeding children under 5 years of age
Authors: Billich Natassja , Dix Clare F. , Palmer Jacqui , Swyripa Ceara , Murawski Beatrice , Truby Helen
Published: April 2024

Introduction

This review identified and appraised Australian open‐access online resources relating to feeding and nutrition during the first 5 years of life.

Methods

Eligible resources were identified by hand searching plus a targeted search of pertinent source websites (government, hospitals and health services, peak bodies, and nutrition organisations) published in English with/without translations to other languages between 2012 and 2022. Search terms relating to the population (children) AND topic (nutrition OR feeding) were entered into Google and Bing. Critical appraisal of each resource was conducted using a modified version of the Centres for Disease Control and Prevention Clear Communication Index.

Results

The search identified 1327 nutrition resources, of which 1067 were appraised. Forty‐five percent were paper‐based resources, 47% were online content only, and 8% audio‐visual resources. Almost half of the resources (45%) broadly addressed the 0–5 years age range, and 24% provided information on breast or formula feeding. Limited resources were found specifically addressing growth and development (5%) and introducing solids (8%). Only 10% of resources were culturally tailored and only 3% were translated into a language other than English. Appraisal showed the majority included visual cues and appropriate language, but less included images to support the main message of the resource.

Discussion

Although there were a large volume of evidence‐based nutrition resources available in Australia for feeding children under 5 years, they were highly dispersed and of varying quality. Collating and presenting these resources in an open‐access resource hub would empower families and education and health professionals in the nutritional care of young children.
A lead article to go deeper and broader in job insecurity research: Understanding an individual perception in its social and political context
Authors: Klug Katharina , Selenko Eva , Van Hootegem Anahí , Sverke Magnus , De Witte Hans
Published: April 2024

Job insecurity, that is, the perceived threat of job loss or of valued job features, is a well‐documented stressor with negative consequences for employees. This lead article proposes to advance the field by going both deeper and broader in linking individual job insecurity experiences to their social context on the microlevel (individual characteristics), the mesolevel (the individual's immediate social context such as organizations) and the macrolevel (the wider context such as countries). Going deeper, we discuss theoretical and methodological approaches to investigate how job insecurity affects employees' experience of work but also their identity and life outside work—essentially, how people view themselves and their place in society. Going broader, we review evidence of macrolevel influences as predictors and moderators of job insecurity, as well as the effects of job insecurity on political attitudes and behaviour. Taken together, we discuss these two streams of research as top‐down and bottom‐up mechanisms in the interplay between individual job insecurity experiences and their socio‐political context. We conclude with suggestions for future research and theory development to move the field forward. We hope to provide a fruitful point of departure to delve into the mechanisms between experiences of job insecurity and the broader social context.
The plasticisation model of dye diffusion: Part 1 introduction
Authors: Burkinshaw Stephen M.
Published: April 2024

This paper introduces a novel plasticisation model of dye diffusion which recognises the fundamentally important mechanistic roles that macromolecule glass transition and water‐induced fibre/polymer plasticisation adopt in aqueous immersion dyeing processes. In essence, the model assumes that the temperature dependent diffusivity of all classes/types of dye molecule within the water‐saturated amorphous domains present in all types of common semi‐crystalline textile fibres/polymers, is governed by the thermally regulated relaxation times of the structural rearrangements occurring within the water‐saturated, water‐swollen, water‐plasticised fibre/polymer, as articulated in terms of the constructs of polymer chain segmental mobility and available free volume.
Expanding from local to continental scale—A genetic assessment of the Eurasian wolverine
Authors: Bujnáková Dominika , Lansink Gerhardus M. J. , Abramov Alexei V. , Bulyonkova Tatiana , Dokuchaev Nikolai E. , Domanov Trofim , Dvornikov Mikhail G. , Graphodatsky Alexander , Karabanina Ekaterina , Kliver Sergei , Korolev Andrey N. , Kozhechkin Vladimir V. , Litvinov Yuri N. , Mamaev Nikolay , Monakhov Vladimir G. , Nanova Olga , Okhlopkov Innokentiy , Saveljev Alexander P. , Schinov Anton , Shiriaeva Elena , Sidorov Mikhail , Tirronen Konstantin F. , Zakharov Evgenii S. , Zakharova Nadezhda N. , Aspi Jouni , Kvist Laura
Published: April 2024

Aim

Our aim was to assess the population structure, genetic diversity and demographic history of the wolverine (Gulo gulo) throughout its entire Eurasian range. Additionally, we aimed to contextualize and put into perspective the state of the endangered Fennoscandian population by emphasizing its connectivity to other populations.

Location

The main study area covered most of the Eurasian wolverine range, with samples from Finland, Russia, Kazakhstan and Mongolia.

Methods

Using a 495 bp fragment of the mitochondrial DNA control region and a frequently used set of 14 microsatellite markers on an extensive dataset of samples, we assessed the population structure, genetic diversity, and demographic history of wolverines with a variety of population genetic analyses.

Results

According to both nuclear and mitochondrial genetic markers, Eurasian wolverines exhibit substructure, with the most distinct population located in Fennoscandia. The Fennoscandian population has undergone a genetic bottleneck, likely influencing its genetic diversity, which is notably the lowest in Eurasia. Genetic diversity in the rest of Eurasia gradually rises towards the central part of the range and decreases again in the east, although not as significantly as in the west.

Main Conclusions

This study reveals the population structure of wolverines across Eurasia and provides direction for allocating conservation efforts to sustain a diverse and connected wolverine population. While most of the Eurasian populations seem to be well‐connected and genetically diverse, the Fennoscandian wolverines may need better connectivity to the other Eurasian populations to ensure gene flow and long‐term persistence. Our study further highlights the importance of considering the population genetic structure and diversity of the entire species range when planning management strategies.
Baby Observational Selective Control AppRaisal (BabyOSCAR): Scores at 3 months predict functional ability, spastic cerebral palsy distribution, and diagnosis at 2 years
Authors: Peyton Colleen , Aaby David , Barbosa Vanessa Maziero , Boswell Lynn , de Regnier Raye‐Ann , Bos Arend F. , Sukal Moulton Theresa
Published: April 2024

Aim

To assess the predictive capabilities of the Baby Observational Selective Control AppRaisal (BabyOSCAR) tool, administered at 3 months corrected age, in determining spastic cerebral palsy (CP) outcome, functional abilities, and body topography at 2 years of age or later.

Method

Independent joint motions were measured at age 10 to 16 weeks from video recordings of spontaneous movement using BabyOSCAR in a sample of 75 infants. All included infants had known 2‐year outcomes (45 with spastic CP and 30 without CP) including Gross Motor Functional Classification System (GMFCS) levels and CP body distribution. Receiver operating characteristic curves and cut points indicating greatest sensitivity and specificity were generated for predictive performance.

Results

Total BabyOSCAR score was a strong predictor of future outcome of spastic CP (cut score of 22.5, sensitivity = 98%, specificity = 100%, area under the curve = 0.99), and was able to distinguish children classified in GMFCS levels I and II from those in III to V (cut score of 13.5, sensitivity = 92%, specificity = 89%, area under the curve = 0.94). Having an (absolute) asymmetry score on the BabyOSCAR of more than 5 was a predictor of having unilateral CP at age 2 years (sensitivity = 56%, specificity = 100%, area under the curve = 0.86).

Interpretation

BabyOSCAR scores are predictors of diagnosis, body distribution, and future gross motor function in infants with spastic CP at 2 years of age or later.

What this paper adds

Decreased independent joint movement at 3 months predicts spastic cerebral palsy (CP) at 2 years.

Baby Observational Selective Control AppRaisal (BabyOSCAR) scores ≤13 are predictive of Gross Motor Function Classification System (GMFCS) levels III to V.

BabyOSCAR scores of 14 to 22 are predictive of GMFCS levels I and II.

A BabyOSCAR total asymmetry score >5 predicts unilateral CP.

Stereotyped movements are more prominent in those who will be diagnosed with spastic CP at 2 years.
Evaluating the potency of zoliflodacin against Helicobacter pylori: In vitro activity and conserved GyrB target
Authors: Liu Jing , Jia Jia , Shi Ting , Bai Yuefan , Huang Yanqiang , Zeng Liping , Bi Hongkai
Published: April 2024

Background

The current standard treatment for Helicobacter pylori infection, which involves a combination of two broad‐spectrum antibiotics, faces significant challenges due to its detrimental impact on the gut microbiota and the emergence of drug‐resistant strains. This underscores the urgent requirement for the development of novel anti‐H. pylori drugs. Zoliflodacin, a novel bacterial gyrase inhibitor, is currently undergoing global phase III clinical trials for treating uncomplicated Neisseria gonorrhoeae. However, there is no available data regarding its activity against H. pylori.

Materials and Methods

We evaluated the in vitro activity of zoliflodacin against H. pylori clinical isolates (n = 123) with diverse multidrug resistance. We performed DNA gyrase supercoiling and microscale thermophoresis assays to identify the target of zoliflodacin in H. pylori. We analyzed 2262 H. pylori whole genome sequences to identify Asp424Asn and Lys445Asn mutations in DNA gyrase subunit B (GyrB) that are associated with zoliflodacin resistance.

Results

Zoliflodacin exhibits potent activity against all tested isolates, with minimal inhibitory concentration (MIC) values ranging from 0.008 to 1 μg/mL (MIC50: 0.125 μg/mL; MIC90: 0.25 μg/mL). Importantly, there was no evidence of cross‐resistance to any of the four first‐line antibiotics commonly used against H. pylori. We identified GyrB as the primary target of zoliflodacin, with Asp424Asn or Lys445Asn substitutions conferring resistance. Screening of 2262 available H. pylori genomes for the two mutations revealed only one clinical isolate carrying Asp424Asn substitution.

Conclusion

These findings support the potential of zoliflodacin as a promising candidate for H. pylori treatment, warranting further development and evaluation.