bluuebunny/crossref_metadata_2025 huggingface dataset:
Frequency-specific oscillations synchronization in primary angle-closure glaucoma
Authors: Jiang Fei , Ye Yin-Quan , Zuo Jin-Min , Huang Xin , Yu Chen , Zeng Xian-Jun
Published: August 2019

Background

Previous neuroimaging studies demonstrated that patients with primary angle-closure glaucoma were accompanied by abnormal neuronal activity.

Purpose

To investigate frequency-dependent local oscillations synchronization in primary angle-closure glaucoma using the regional homogeneity method.

Material and Methods

In total, 37 individuals with primary angle-closure glaucoma (20 men, 17 women) and 37 normal-sighted controls (20 men, 17 women) closely matched in age, sex, and education underwent resting-state MRI scans. We compared the different regional homogeneity values in full band (0.01–0.08 Hz) and two different frequency bands (slow-4: 0.027–0.073 Hz and slow-5: 0.010–0.027 Hz) between two groups.

Results

Compared to the normal-sighted group, the primary angle-closure glaucoma group showed decreased regional homogeneity values in the left calcarine and left postcentral in full band. The primary angle-closure glaucoma group showed increased regional homogeneity values in the bilateral superior medial frontal lobe in the slow-4 band. The primary angle-closure glaucoma group exhibited decreased regional homogeneity values in the right calcarine in the slow-5 band. Specifically, we found that the regional homogeneity values in the right superior frontal lobe were greater in the slow-4 than in the slow-5 band, whereas regional homogeneity in the left calcarine, right pallidum, left inferior occipital gyrus, left superior occipital gyrus, left postcentral/angular gyrus, left paracentral lobule, left superior parietal gyrus, and right precuneus gyrus were greater in the slow-5 than in the slow-4 band.

Conclusion

Primary angle-closure glaucoma groups showed abnormal regional homogeneity in visual network (calcarine) and default mode network (superior medial frontal lobe) at two frequency bands. Moreover, the regional homogeneity signals in slow-5 band showed closely related to the severity of individuals with primary angle-closure glaucoma.
Effect of hypothermia on haemostasis and bleeding risk: a narrative review
Authors: Kander Thomas , Schött Ulf
Published: August 2019

It must be remembered that clinically important haemostasis occurs in vivo and not in a tube, and that variables such as the number of bleeding events and bleeding volume are more robust measures of bleeding risk than the results of analyses.

In this narrative review, we highlight trauma, surgery, and mild induced hypothermia as three clinically important situations in which the effects of hypothermia on haemostasis are important. In observational studies of trauma, hypothermia (body temperature <35°C) has demonstrated an association with mortality and morbidity, perhaps owing to its effect on haemostatic functions. Randomised trials have shown that hypothermia causes increased bleeding during surgery. Although causality between hypothermia and bleeding risk has not been well established, there is a clear association between hypothermia and negative outcomes in connection with trauma, surgery, and accidental hypothermia; thus, it is crucial to rewarm patients in these clinical situations without delay. Mild induced hypothermia to ≥33°C for 24 hours does not seem to be associated with either decreased total haemostasis or increased bleeding risk.
The Role of Perceived Legitimacy and Its Effect on Prison Adaptation: A Longitudinal Study on a Chinese Juvenile Prison
Authors: Zhao Jihong (Solomon) , Wang Xinting , Zhang Hongwei
Published: August 2019

Research into offenders’ adaptation to prison environment has been a topic of enduring interest. Recently, perceived legitimacy in corrections has attracted considerable attention and emerged as an important area of research in the prison settings. The purpose of this study is to examine the factors associated with perceived legitimacy in corrections, and document its effect on juvenile offenders’ adaptation to the institutional environment of a Chinese youth prison. Data for the analysis were collected from the lone youth prison located in an autonomous region with more than 47 million persons of varying ethnicity. Using structural equation modeling (SEM), the findings suggest a significant effect for perceived legitimacy on juvenile offender adaptation to prison programs. The final model was able to explain 61% of variation in the outcome variable and identify several prominent contributors to perceived legitimacy. Policy implications were highlighted in the “Discussion and Conclusion” section.
Representations of Women Subjected to Violence: A Critical Discourse Analysis of Study Guides in Social Work
Authors: Hoppstadius Helena
Published: August 2019

The Swedish government’s efforts to meet the needs of women subjected to violence have intensified since 2007 when it adopted an Action Plan for combating men’s violence against women. The aim of this study was to analyze how women are discursively framed from an intersectional perspective in five of the Action Plan’s study guides. A critical discourse analysis revealed three overall discourses. First, women are divided into various categories, which is likely to lead to an understanding that it is specific groups of women that become victims of violence. Second, women are framed in a heteronormative and a gender-equal context. This neglects nonheterosexual violence and underlines the otherness of ethnically categorized women. Third, the definition of women as agents stresses both their responsibility and their lack of agency. The absence of an intersectional analysis risks an interpretation in social work practice that some social division have a greater impact on violence in some specific groups of women. When women’s individual situation and needs are not taken into account, women risk being given inadequate help and support, which might put victims of violence in danger.
Perpetrators’ Perspectives on Family Violence: An Event Process Model
Authors: Stairmand Meg , Polaschek Devon L. L. , Dixon Louise
Published: August 2019

Offense process models are descriptive theories that provide a temporal outline of an offense—including its cognitive, behavioral, contextual, and motivational components—from a perpetrator’s perspective. Offense process models have been developed for a wide range of criminal offending (e.g., alcohol-impaired driving, child sexual offending, rape, aggravated robbery, homicide), but remain underdeveloped for family violence. The purpose of this study was to develop an offense process model of family violence. We conducted individual semistructured interviews with 27 participants—14 men and 13 women—completing community-based family violence perpetrator treatment programs, and systematically analyzed participants’ narratives of family violence events using grounded theory methods. The resulting event process model of family violence (FVEPM) contains four sections, arranged temporally from the most distal to the most proximal factors in relation to the family violence event: (1) background factors, (2) event build-up, (3) event, and (4) post-event. Each section outlines the cognitive, behavioral, contextual, and motivational factors that contribute to family violence perpetration. The FVEPM is the first attempt to consider whether a single offense process model can account for a broader range of family violence than that used solely by men toward their female intimate partners. Furthermore, the FVEPM highlights the dynamic nature of family violence events (FVEs), and the salient role of situational and interpersonal factors in contributing to family violence perpetration. We argue that the FVEPM has the potential to accommodate a range of types of family violence perpetration, and makes a useful contribution to theory and research on event-based models from a perpetrator perspective.
Design guidelines for the striker and transfer flange of a split Hopkinson tension bar and the origin of spurious waves
Authors: Shin Hyunho , Lee Jae-Ha , Kim Jong-Bong , Sohn Sung-Ik
Published: August 2019

Characteristics of the stress pulse generated by impact of a hollow striker on the flange of a split Hopkinson tension bar are investigated via an explicit finite element analysis. Design guidelines are extracted for the hollow striker and flange from the viewpoint of eliminating spurious waves located between the incident and reflected pulses. According to design guidelines, it is desirable to have a striker cross-sectional area the same as that of the flange. It is also desirable to make the cross-sectional area of the striker (flange) the same as that of the bar. As for the flange length, it is recommended to be comparable to the diameter of the bar. The magnitude and duration of the primary stress pulse are consistent with the results of a one-dimensional analysis even when spurious waves are present; meanwhile, overly long spurious waves should be avoided to eliminate their superposition with the reflected pulse. Spurious waves appear when general impedance of the striker is higher than the bar. The origin of spurious waves is a series of step-wise residual pulses generated by multiple cycles of striker impact that make the striker keep compressing the flange after the first cycle of impact. Step-wise residual pulses appear in two forms (continuous waves and discrete waves) in spurious waves due to the secondary impacts during the entrance process of step-wise residual pulses to the flange. The consequences of spurious waves in the use of split Hopkinson tension bars are discussed.
Active shape control of an antenna reflector using piezoelectric actuators
Authors: Song Xiangshuai , Tan Shujun , Wang Enmei , Wu Shunan , Wu Zhigang
Published: August 2019

The surface precision of an antenna reflector can be improved using the actuation of piezoelectric materials to obtain a high-performance space antenna. In this study, the active shape control of a reflector with piezoceramic (lead zirconate titanate) actuators assembled on ribs is proposed by theoretical and experimental approaches. A finite element model of the integrated reflector–actuator system is established using piezoelectric constitutive equations and the virtual work’s principle. For a desired shape, a closed-loop iterative shape control method based on the influence coefficient matrix model is developed, which resolves the issue of high-precision shape control of the antenna reflector in the presence of model errors. The shape controller based on the proposed closed-loop shape control method is implemented on a planar hexagonal reflector with 30 lead zirconate titanate actuators. Experimental results demonstrate that the closed-loop control is an effective way to improve the surface precision of the reflector considering uncertainties.
The Use of Online Physician Training Can Improve Patient Experience and Physician Burnout
Authors: Congiusta Susan , Ascher Eric M. , Ahn Seungjun , Nash Ira S.
Published: August 2019

The authors tested the efficacy of an integrated approach to improving patient experience and physician burnout using a 24-week online training program coupled with a physician engagement strategy. Physicians from different disciplines were randomized to intervention (n = 30) and control (n = 33) groups. Patient experience, physician burnout, and satisfaction data were assessed using patient and provider surveys. Comparisons were made pre and post intervention, and between the groups. Intervention group mean scores increased (+1.40 points) while control group scores dropped (−0.11 points; P = .039). Scores on physician burnout surveys for the intervention group improved in all areas and changes in 2 domains were statistically significant. In all, 73.5% of physicians felt the program was effective. This integrated intervention enhanced patient experience scores and positively affected physicians’ level of burnout, and physicians believed this exercise was useful.
Flexible Fixation Technique for Lisfranc Injuries
Authors: Delman Connor , Patel Midhat , Campbell Mark , Kreulen Christopher , Giza Eric
Published: August 2019

Injuries to the Lisfranc complex range from purely ligamentous disruptions to fracture-dislocations of the tarsometatarsal joint. Treatment options include closed/open reduction with percutaneous pinning, open reduction and internal fixation (ORIF), and primary arthrodesis. We present a ligament reinforcement technique utilizing a flexible fixation device for the treatment of ligamentous Lisfranc injuries.

Level of Evidence: Level V, expert opinion.
Developmental and Sexual Offense Onset Characteristics of Australian Indigenous and Non-Indigenous Male Youth Who Sexually Offend
Authors: Adams Dimity , McKillop Nadine , Smallbone Stephen , McGrath Andrew
Published: August 2019

The present study sought to address gaps in knowledge concerning Australian Indigenous and non-Indigenous youth who commit sexual offenses. Developmental histories and onset sexual offense characteristics of Indigenous ( n = 81) and non-Indigenous ( n = 130) adjudicated male youth were compared. Results indicate that, in addition to problems affecting both groups, Indigenous youth in this sample were disproportionately exposed to systemic vulnerabilities (e.g., familial antisocial attitudes and incarceration, engagement with antisocial peers, poor school engagement and voluntary school dropout, low socioeconomic status) associated with onset of sexual offending. Differences in the circumstances and context surrounding the onset sexual offense (e.g., use of drugs/alcohol, relationship to person harmed, co-offending, age of person harmed, location, threats/force) were also found. When these analyses were stratified by age of person harmed, these differences were retained only for offenses against children below 16 years. Together, these findings highlight the need for more contextualized primary-, secondary-, and tertiary-level prevention efforts to reduce youth sexual offending in Australia and elsewhere.
Elastic waves in a circular cylinder and cylindrical annulus for a subclass of implicit constitutive equations
Authors: Magan Avnish Bhowan , Mason David , Harley Charis
Published: August 2019

The propagation of elastic waves in a circular cylinder and cylindrical annulus for two types of power-law constitutive equations is investigated. These power-law constitutive equations can describe elastic responses where the linearised strain and stress are nonlinearly related. These constitutive equations are a subclass of the more general class of implicit constitutive equations and are characterised by expressing the strain as a non-invertible function of the stress. Pseudo-solitary stress wave solutions for both types of constitutive equations in the circular cylinder and cylindrical annulus are derived. We find that for the power-law constitutive equation of Type I, a shock front will develop at the back of the wave while for the power-law constitutive equation of Type II, a shock front will develop at the front of the wave. Estimates of the times at which the shock front will develop are given. Standing wave solutions for both types of constitutive equations in the circular cylinder and cylindrical annulus are also obtained and the periods of oscillation are compared.
CNS Safety Screening Under ICH S7A Guidelines Requires Observations of Multiple Behavioral Units to Assess Motor Function
Authors: Gauvin David V. , Zimmermann Zachary J. , Dalton Jill A. , Baird Theodore J. , Kallman Mary-Jeanne
Published: August 2019

In the adoption of behavior as a critical end point in safety pharmacology and neurotoxicity screening, federal regulatory agencies have shifted the predominating scientific perspective from pharmacology back to the experimental analysis of behavior (psychology). Nowhere is this more evident than in tier I safety assessment of the central nervous system (CNS). The CNS and peripheral nervous system have multiple behavioral units of general activity. A complete picture of the motor control neural pathways cannot be measured by any one single approach. The CNS safety protocols under International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use S7A are required to be conducted in accordance with Good Laboratory Practices by trained technical staff. The CNS safety assessments necessitate the inclusion of a thorough and detailed behavioral analysis of home cage activity, the response to handling, and transportation to and observations within an open-field apparatus with ancillary measures of basal muscle tone, muscle strength, and tremor in a functional observation battery, as well as quantitative measurements of 3-dimensional activity in an automated photobeam arena. Cost-cutting initiatives or a radical application of the “reduce use” principle of the 3 Rs only jeopardize the spirit, intent, and predictive validity of tier I safety testing assays dictated by current drug safety guidelines.
Interspecies Comparison of Control Data From Embryo–Fetal Development Studies in Sprague-Dawley Rats, New Zealand White Rabbits, and Göttingen Minipigs
Authors: Paradis France-Helene , Downey Anne Marie , Beaudry Francine , Pinêtre Clémentine , Ellemann-Laursen Sisse , Makin Andy , Hill Katherine , Singh Pramila , Hargitai Judit , Forster Roy , Tavcar Robert , Authier Simon
Published: August 2019

Species-dependent differences in relative incidence of spontaneous variations and malformations should be considered in the assessment of the translational value of reproductive and developmental safety assessments. The objective of this evaluation was to compare litter parameters and the frequency of external, visceral, and skeletal malformations and variations across species in the Sprague-Dawley rat, New Zealand White rabbit, and Göttingen minipig and to determine whether notable differences exist. Pregnant female rats (n = 824), rabbits (n = 540), and minipigs (n = 70) from vehicle control groups were included in the analysis, equating to 10,749 rat, 5,073 rabbit, and 378 pig fetuses collected at term by cesarean delivery. Preimplantation loss was more frequent than postimplantation loss in the rat and rabbit, whereas the opposite was observed in the minipig. Several external and visceral malformations and variations such as domed head, bent tail, abdominal edema, and anal atresia were observed in all 3 species. Visceral malformations of the heart and major blood vessels were remarkably more frequent in the minipig and rabbit, respectively; ventricular and atrium septum defects were observed in 1.9% and 2.1%, respectively, for the minipig fetuses, whereas they were observed in equal or less than 0.02% among the rat and rabbit fetuses evaluated in this study. Understanding species-dependent differences in spontaneous variations and malformations can be useful for the interpretation of embryo–fetal development study results. The current analysis identified relevant differences between commonly used species in reproductive toxicology with potential implications for data assessment.
Intersections of US Military Culture, Hegemonic Masculinity, and Health Care among Injured Male Service Members
Authors: Cogan Alison M. , Haines Christine E. , Devore Maria D.
Published: August 2019

In this paper, we explore how socially constructed hegemonic masculinity permeates military culture, and how this cultural context intersects with the seeking and receiving of health care by active-duty US military service members with chronic mild traumatic brain injury (mTBI) (n = 18). Data were collected through individual interviews and focus groups. Using Bourdieu’s theory of practice as an analytical framework, we identified four themes: maintenance of social capital, remaining in the field, reframing health care use to bolster social capital, and risk of health care use as not being rewarded. Each emerged from statements about why participants had avoided seeking health care for physical and psychological needs during their military service. We consider our findings in the context of maintaining status within an institutional steeped in hegemonic masculinity and describe implications for reframing caring for the body and dealing with problems as masculine acts.
Singapore teachers’ attitudes towards the use of information and communication technologies in physical education
Authors: Tou Nien Xiang , Kee Ying Hwa , Koh Koon Teck , Camiré Martin , Chow Jia Yi
Published: August 2019

The purpose of the present study was to examine and compare Singaporean physical education teachers’ attitudes towards information and communication technologies in physical education across different demographic groups that included gender, age, teaching experience, and school level. A total of 422 Singaporean full-time physical education teachers (mean age = 38.47 years, standard deviation = 8.31) completed the Physical Education Teachers’ Subjective Theories Questionnaire to assess their perspectives towards the integration of information and communication technologies into physical education teaching practice. Mann–Whitney U and Kruskal–Wallis H tests were conducted to examine the differences in participants’ attitudes across different demographic groups. Results revealed that attitudes towards information and communication technologies significantly differed between teachers of different gender, age, and teaching experience. However, no significant difference was found in attitudes towards information and communication technologies among teachers of different school levels. The findings of this study can inform policy-makers and stakeholders with an interest in promoting the integration of information and communication technologies in physical education.
Linguistic mediation and code-to-weave transformation in Kashmiri carpet weaving
Authors: Kaur Gagan Deep
Published: August 2019

This article describes the process of transforming a symbolic code into weave actions of weavers in Kashmiri carpet weaving and how a trade-specific language features crucially in this transformation. The designs in Kashmiri carpet weaving are encoded in a symbolic code, called talim, which the weavers decode while weaving the design. This transformation from code-to-weave is achieved by subjecting the code to various interpretative frameworks, that is, modality and linguistic, and weaving actions are aligned in accordance with them. The transformation remains similar in single and multi-weaver settings, with an exception that, in the latter, the code is read aloud in practice-specific trade language among the team of weavers.
Experimental analysis of composite scarf adhesive joints modified with multiwalled carbon nanotubes under bending and thermomechanical impact loads
Authors: Khashaba UA , Othman Ramzi , Najjar IMR
Published: August 2019

Scarf adhesive joints have attracted an increasing attention in joining/repairing of carbon fiber reinforced epoxy composite structures due to their zero eccentricity, which provides lower stress distribution across the adhesive layer and better aerodynamic surfaces compared to other bonded joints. The main objective of this study is to evaluate the performance of the scarf adhesive joints in carbon fiber reinforced epoxy composites under thermomechanical impact loads, which is very important for the aerospace and automotive industries. The adhesive was modified with optimum percentage of multiwalled carbon nanotubes. The impact tests were performed at 25 ℃, 50 ℃, and 75 ℃. The residual flexural properties of the unfailed impacted joints were measured using three-point bending test. Results from impact tests at 25 ℃, 50 ℃, and 75 ℃ showed improvement in the impact bending stiffness of the modified scarf adhesive joints by 8.3%, 7.4%, and 11.8% and maximum contact force by 15.6%, 21.3%, and 18.9%, respectively. The energy at failure of the modified scarf adhesive joints with multiwalled carbon nanotubes was improved by 15.2% and 16.4% respectively at 25 ℃ and 50 ℃. At test temperature of 75 ℃, the scarf adhesive joints have hysteresis load–displacement behavior and energy–time curve with rebound energy of 35% and absorbed (damage) energy of 65%. The residual flexural strength of the modified and unmodified scarf adhesive joints is 98.2% and 86.1% respectively, while their residual moduli have remarkable decrease to 71.7% and 81.3%.
Supporting self-management education for arthritis: Evidence from the Arthritis Conditions and Health Effects Survey on the influential role of health care providers
Authors: Murphy Louise B , Theis Kristina A , Brady Teresa J , Sacks Jeffrey J
Published: August 2019

Objective

Self-management education programs are recommended for many chronic conditions. We studied which adults with arthritis received a health care provider’s recommendation to take a self-management education class and who attended.

Methods

We analyzed data from a 2005--2006 national telephone survey of US adults with arthritis ≥45 years ( n = 1793). We used multivariable-adjusted prevalence ratios (PR) from logistic regression models to estimate associations with: (1) receiving a health care provider recommendation to take a self-management education class; and (2) attending a self-management education class.

Results

Among all adults with arthritis: 9.9% received a health care provider recommendation to take an self-management education class; 9.7% attended a self-management education class. Of those receiving a recommendation, 52.0% attended a self-management education class. The strongest association with self-management education class attendance was an health care provider recommendation to take one (PR = 8.9; 95% CI = 6.6–12.1).

Conclusions

For adults with arthritis, a health care provider recommendation to take a self-management education class was strongly associated with self-management education class attendance. Approximately 50% of adults with arthritis have ≥1 other chronic conditions; by recommending self-management education program attendance, health care providers may activate patients’ self-management behaviors. If generalizable to other chronic conditions, this health care provider recommendation could be a key influencer in improving outcomes for a range of chronic conditions and patients’ quality of life.
Is Digital Health for Diabetes in an Investment Bubble?
Authors: Klonoff David C. , Evans Bill , Zweig Megan , Day Sean , Kerr David
Published: August 2019

An investment bubble occurs when there is a surge in asset prices that is not warranted by asset fundamentals because of irrationally exuberant market behavior. When prices rise to a level where no additional investors are willing to buy at the elevated price, then a massive sell-off typically occurs. Digital health investments represent approximately 10% of venture capital-backed startup investments, and diabetes digital health startups represent 4% of digital health investments. Attributes of a bubble indicate evidence for and against the current time period being in an investment bubble for digital health startups. After analyzing these attributes as well as the overall economy and the demand for healthcare products, we conclude that digital health startups and particularly digital health startups for diabetes are not in a bubble.
Does helicopter transport delay prehospital transfer for STEMI patients in rural areas? Findings from the CRAC France PCI registry
Authors: Hakim Radwan , Revue Eric , Saint Etienne Christophe , Marcollet Pierre , Chassaing Stephan , Decomis Marie Pascale , Yafi Wael , Laure Christophe , Gautier Sandra , Godillon Lucile , Akkoyun-Farinez Julie , Angoulvant Denis , Koning Rene , Motreff Pascal , Grammatico-Guillon Leslie , Rangé Gregoire
Published: September 2019

Aims:

The aim of this study was to analyse delays in emergency medical system transfer of ST-segment elevation myocardial infarction (STEMI) patients to percutaneous coronary intervention (PCI) centres according to transport modality in a rural French region.

Methods and results:

Data from the prospective multicentre CRAC / France PCI registry were analysed for 1911 STEMI patients: 410 transferred by helicopter and 1501 by ground transport. The primary endpoint was the percentage of transfers with first medical contact to primary percutaneous coronary intervention within the 90 minutes recommended in guidelines. The secondary endpoint was time of first medical contact to primary percutaneous coronary intervention. With helicopter transport, time of first medical contact to primary percutaneous coronary intervention in under 90 minutes was less frequently achieved than with ground transport (9.8% vs. 37.2%; odds ratio 5.49; 95% confidence interval 3.90; 7.73; P<0.0001). Differences were greatest for transfers under 50 km (13.7% vs. 44.7%; P<0.0001) and for primary transfers (22.4% vs. 49.6%; P<0.0001). The median time from first medical contact to primary percutaneous coronary intervention and from symptom onset to primary percutaneous coronary intervention (total ischaemic time) were significantly higher in the helicopter transport group than in the ground transport group (respectively, 137 vs. 103 minutes; P<0.0001 and 261 vs. 195 minutes; P<0.0001). There was no significant difference in inhospital mortality between the helicopter and ground transport groups (6.9% vs. 6.6%; P=0.88).

Conclusions:

Helicopter transport of STEMI patients was five times less effective than ground transport in maintaining the 90-minute first medical contact to primary percutaneous coronary intervention time recommended in guidelines, particularly for transfer distances less than 50 km.
Posterior acetabular uptake on 18F-fluoride positron emission tomography/computed tomography reveals a putative contrecoup region in patients with femoroacetabular impingement
Authors: Oishi Takayuki , Kobayashi Naomi , Choe Hyonmin , Tezuka Taro , Kobayashi Daigo , Higashihira Shota , Inaba Yutaka
Published: August 2019

Background and purpose:

The pathology of the posterior acetabular lesions, so-called “contrecoup regions”, in femorocacetabular impingement (FAI) has not been elucidated fully. 18F-fluoride positron emission tomography/computed tomography (PET/CT) can visualize abnormal uptake caused by impingement. Therefore, we aimed to evaluate posterior acetabular uptake on PET/CT in FAI patients.

Patients and methods:

Patients with FAI who underwent 18F-fluoride PET/CT between October 2014 and October 2016 were retrospectively evaluated. The maximum standardized uptake value (SUVmax) in the posterior acetabulum was evaluated. The mean SUVmax of FAI with cam morphology (the cam group) was compared with that of FAI with pincer morphology (the pincer group). In addition, the numbers of cases with SUVmax ≥ 6 and SUVmax < 6 in each group were evaluated. The entire study cohort was also grouped according to SUVmax, and the mean α and center edge angles were evaluated.

Results:

In total, 41 hips were analyzed (34 hips in the cam group and 7 in the pincer group). The mean SUVmax of the cam group (11.2 ± 7.4) was significantly higher than that of the pincer group (4.9 ± 1.9) ( p < 0.01). The incidence of cases with SUVmax ≥ 6 in the cam group was significantly high ( p < 0.01). In the overall cohort, the mean α angle of the SUVmax ≥ 6 group was significantly higher than that of the SUVmax < 6 group ( p < 0.01).

Conclusion:

Evaluation of posterior acetabular uptake suggests an association between cam morphology and increased posterior acetabular uptake.
Contesting austerity, de-centring the state: Anti-politics and the political horizon of the urban
Authors: Beveridge Ross , Koch Philippe
Published: August 2019

This article draws novel links between ‘anti-politics’, austerity and a political horizon centred on the urban. Research on anti-politics often invokes a binary understanding of a politics of and within the state and an anti-politics at a distance from or hostile towards the state. This article argues that in the context of austerity, this binary loses traction. Austerity has intensified the transformation towards networked forms of governance within which the state becomes a more hybrid entity of contradictory ideals and practices. Austerity not only calls into question the legitimacy of formal politics because of its devastating social outcomes, it also disaggregates the political authority of the state and opens up a particularly urban terrain of politics. We capture this development by examining the intersections between the local state and the urban field of politics. Looking across the struggles against austerity in Europe, and focusing in more detail on housing politics in Berlin, we assert that the urban is important not only as a setting (as typically argued) but also as the basis for a different rationality of political action in and against austerity. In the context of austerity struggles, state authority becomes ever more contingent and other, more urban, forms of politics advance. In sum, the article contributes to a spatial reading of (anti-)politics against austerity, points to the de-centring of the state in transformative political projects and emphasizes the analytical purchase of a distinctly urban perspective on contemporary politics in Europe.
Diagnostic imaging in adult non-cystic fibrosis bronchiectasis
Authors: Juliusson Gunnar , Gudmundsson Gunnar
Published: September 2019

Radiology plays a key role in the diagnosis of bronchiectasis, defined as permanent dilatation of the bronchial lumen. Volumetric thin-section multidetector computed tomography is an excellent noninvasive modality to evaluate bronchiectasis. Bronchiectasis is categorised by morphological appearance. Cylindrical bronchiectasis has a smooth tubular configuration and is the most common form. Varicose bronchiectasis has irregular contours with alternating dilating and contracting lumen. Cystic bronchiectasis is the most severe form and exhibits saccular dilatation of bronchi. Bronchial dilatation is the hallmark of bronchiectasis and is evaluated in relation to the accompanying pulmonary artery. A broncho–arterial ratio exceeding 1:1 should be considered abnormal. Normal bronchi are narrower in diameter the further they are from the lung hila. Lack of normal bronchial tapering over 2 cm in length, distal from an airway bifurcation, is the most sensitive sign of bronchiectasis. Findings commonly associated with bronchiectasis include bronchial wall thickening, mucus plugging and tree-in-bud opacities. Bronchiectasis results from a myriad of conditions, with post-infectious bronchiectasis being the most common. Imaging can sometimes discern the cause of bronchiectasis. However, in most cases it is nonspecific or only suggestive of aetiology. While morphological types are nonspecific, the distribution of abnormality offers clues to aetiology.

Key points

Bronchiectasis is a chronic progressive condition with significant disease burden and frequent exacerbations, for which the diagnosis relies on cross-sectional imaging.

The major imaging findings include bronchial dilatation, bronchial contour abnormalities and visualisation of the normally invisible peripheral airways.

Bronchiectasis is the end result of various conditions, including immunodeficiencies, mucociliary disorders and infections. Imaging is often nonspecific with regard to aetiology but can be suggestive.

Distribution of abnormality in the lung offers helpful clues for establishing aetiology.

Educational aims

To review the cross-sectional imaging appearance of bronchiectasis and the common associated findings.

To get a sense of how radiology can aid in establishing the aetiology of bronchiectasis.
Update of the European paediatric respiratory medicine syllabus
Authors: Primhak Robert , Tabin Nathalie , Beydon Nicole , Bhatt Jayesh , Eber Ernst , Hammer Jürg , Martinez-Gimeno Antonio , Midulla Fabio , Nenna Raffaella , Paton James , Ross Russell Robert
Published: September 2019

The 10-year-old European syllabus for paediatric respiratory medicine (PRM; also known as paediatric pulmonology) was updated by a consensus-based method using an expert task force for redrafting, and a subsequent Delphi process to achieve consensus. There was a high degree of consensus for the final syllabus, which has been streamlined and made more relevant to current practice. All modules are now mandatory apart from the undertaking of research projects, which is optional. Although there are still a number of countries in Europe which do not recognise PRM as a separate subspecialty, there are paediatric respiratory physicians practising in every country in Europe, and a current and harmonised European syllabus in the subspecialty remains important for defining the training and areas of practice of PRM practitioners.
Hot topics and current controversies in community-acquired pneumonia
Authors: Severiche-Bueno Diego , Parra-Tanoux Daniela , Reyes Luis F. , Waterer Grant W.
Published: September 2019

Community-acquired pneumonia (CAP) is one of the most common infectious diseases, as well as a major cause of death both in developed and developing countries, and it remains a challenge for physicians around the world. Several guidelines have been published to guide clinicians in how to diagnose and take care of patients with CAP. However, there are still many areas of debate and uncertainty where research is needed to advance patient care and improve clinical outcomes. In this review we highlight current hot topics in CAP and present updated evidence around these areas of controversy.
Workplace-based assessment: how to use case-based discussion as a formative assessment
Authors: Primhak Rob , Gibson Neil
Published: September 2019

Workplace-based assessments are increasingly used as a way of gaining insight into clinician performance in real-life situations. Although some can be used to inform a summative (pass/fail) assessment, many have a much greater role in the formative assessment of trainees, and can be used as tools for teaching and training and in identifying the development needs of trainees. There is considerable variation between different European countries in the use of formative, workplace-based assessment, such as a structured case-based discussion (CbD), during training. This article gives an overview of how to use CbD as a formative assessment for higher specialist trainees, and gives access to a downloadable record form which can be used by trainers.
Violent behaviour as a result of delirium superimposed on dementia in the course of primary central nervous system lymphoma
Authors: Turek Aleksander , Machalska Karolina , Bezshapkin Valentyn , Chrobak Adrian , Siwek Marcin , Dudek Dominika
Published: September 2019

Primary central nervous system lymphoma is a rare neoplasm, exceptionally responsible for developing a frontal lobe syndrome. A 71-years-old patient with primary central nervous system lymphoma had undergone frontotemporal craniotomy for tumor removal. Month later, showing syncopies, disorientation and slurred speech, he was transported to Department of Internal Medicine. Neuroimaging revealed numerous tuberous changes in frontal and parietal lobes and frontotemporal area. During hospitalization, patient exhibited inadequate affect, jocular behaviour, was disoriented in the place and time, and unaware of his health state. He took repeated, uncritical attempts to jump out the window and started to exhibit persecutory delusions and hallucinations. Immediate brain radiotherapy was recommended by the oncology specialists. However, the patient did not consent to the recommended method of treatment due to his lack of recollection of the tumor or the craniotomy. The patient was forcibly transferred to Department of Psychiatry. After five weeks of treatment, the patient's condition improved significantly, and the patient regained memory of the tumor.
A Study on the Indigenous Methods of Processing Milk in Niger
Authors: Gagara Mariama Hima , Sessou Philippe , Dossa Francois , Ahounou Serge , Azokpota Paulin , Youssao Issaka , Gouro Abdoulaye Soumana , Farougou Souaibou
Published: August 2019

The purpose of this study was to identify the methods of processing and preserving of local milk within the area of Liptako-Gourma in ​​Niger. A survey was conducted and data were collected from 600 people involved in dairy sector, comprising of 59% producers, 28.7% collectors and 12.3% processors. The study also revealed two main methods of milk processing that is pasteurization and fermentation comprising of natural/spontaneous fermentation done by 42.9% and fermentation method by backslopping practiced by 57.10% of processors. In addition, four methods of preserving milk were identified, including the cooling of raw milk, pasteurized or fermented milk, the pasteurization of raw milk itself for sale or for processing, the fermentation of raw milk or pasteurized milk and the addition of guinea pepper pods to fermented milk. Milk processing and preserving technology remains traditional with no compliance to hygiene good practices and the use of old material being limited most often to the strict minimum. Due to these results, attention should be paid to the training of the processors on hygiene and good practices at all levels of the local milk industry in order to improve traditional methods related to the processing and preserving of local milk and thus raising the quality of the dairy products in terms of microbiological safety.
Phenolic Compound Profile and Functionality of Aqueous Overripe Tempe Extracts
Authors: Athaillah Zatil Afrah , Muzdalifah Dian , Lestari Asri , Devi Anastasia Fitria , Udin Linar Zalinar , Artanti Nina , Lioe Hanifah Nuryani
Published: August 2019

Tempe is a soy fermentation product and has been associated with many health benefits. It is usually consumed after 48 hours of fermentation; however extended fermentation is sometimes favoured. Since cooking involves water, it is of interest to study the health benefits of tempe water extract. In this study, we focused our study on total phenols, total flavonoids, DPPH free radical scavenging activity, cytotoxic activity, and identification of the main flavonoids. Our findings demonstrated that concentration of water-soluble flavonoids in tempe increased as fermentation time was prolonged. Fermentation for 60 hr resulted in extracts with very noticeable cytotoxic activity against MCF-7 cancer cell line (IC50 of 8.70 µg/ml). The cytotoxic activity of the extracts was fermentation time-dependent following non-linear relationship. The activity showed strong inverse correlation with total phenols and flavonoids in the extracts. LC-MS/MS data suggested that extracts from control and 24-hr fermented tempe demonstrated the highest responses for genistein, genistin, daidzein, daidzin, and glycitein, compared to those of other treatments and therefore suggested that excessive amount of the isoflavones, particularly genistein, induced cancer cell proliferation but lesser yet optimum concentration (observed at 60 hr-fermentation) contributed to otherwise effect.
In Vitro Modulation of Fecal Microflora Growth Using Fermented “Pisang Mas” Banana and Red Guava Juices
Authors: Arum Dalu Kiky Chily , Nurhayati Nurhayati , Jayus Jay
Published: August 2019

Probiotic drink like yoghurt from dairy milk is one of the most popular functional food. However, some people are not able to consume dairy milk due to lactose intolerance. Thus, a substitute substrate such as fruit juice, is needed. It refers to prebiotic compounds that are found in some of fruits like banana and guava. The aim of this research was to determine the effect of fermented banana and guava juices on the viability of fecal microflora. The juices were made from banana or red guava fermented by Lactobacillus casei (15% v/v). In vitro test was conducted using indigenous human fecal bacteria (1% w/v). The viability of enteropathogens, lactic acid bacteria (LAB), and total microbes was determined by enumeration as well as the prebiotic index of the fermented juices. The in vitro test results showed that both fermented juices could elevate the total microbes and LAB as compared to control sample. The viability of the total microbes and LAB increased by 2.16 log CFU/mL and 2.90 log CFU/mL for fermented banana juice (FBJ), respectively. The same trend was also observed in fermented guava juice (FGJ) with an increase by 1.92 log CFU/mL for total microbes and 2.99 log CFU/mL for LAB. Interestingly, both fermented juice could decrease the population of most enteropathogens compared to control sample. FBJ could decrease the population of E. coli, Klebsiella sp. and Salmonella as low as 3.78, 3.32, and 1.37 log CFU/mL respectively. Meanwhile, FGJ could drop the number of E. coli (1.44 log CFU/mL), and Klebsiella sp. (1.29 log CFU/mL). Moreover, the prebiotic index for FBJ and FGJ were 2.57 and 2.16. In conclusion, both FBJ and FGJ were potential substrate for probiotic drink and had good effect for fecal microflora health.
Impact of low 25-Hydroxyvitamin D on Handgrip Strength in adult Chinese population
Authors: Chi Vu Thi Quynh , Q. Tran Kham
Published: August 2019

Decreased grip strength is a predictor of adverse outcomes such as disability, immobility, falls, or mortality in the elderly population. Low serum 25-Hydroxyvitamin D has been linked to grip strength. However, its relationship in the adult Chinese population remains unclear. This cross-sectional study involves 4,720 participants in Tianjin, China. Handgrip strength was calculated by a dynamometer (EH101. CAMRY, Guangdong, China). Serum 25(OH)D was assessed by enzyme immunoassay method. The analysis of covariance was used to assess the relation between serum 25-Hydroxyvitamin D and handgrip strength. Among total participants, 36.25% were aged over 50 years and 63.75% under 50 years. For participants over 50 years, the results of handgrip strength per body weight (kg/kg) across serum 25-Hydroxyvitamin D were 0.46, (0.40, 0.52); 0.47, (0.41, 0.53); 0.47, (0.42, 0.53); 0.47, (0.42, 0.53) (Ptrend=0.01), and the results of handgrip strength were 31.7, (27.9, 36.0); 32.5, (28.6, 36.9); 32.6, (28.7, 37.1); 32.8, (28.9, 37.3) (Ptrend=0.02) after adjusting all confounders. However, this relation was not found in subjects under 50 years. Our study showed that low vitamin D was significantly linked to low handgrip strength in subjects aged over 50 years.
Robot-assisted unicompartmental knee arthroplasty for patients with isolated medial compartment osteoarthritis is cost-effective
Authors: Clement Nick D. , Deehan David J. , Patton James T.
Published: August 2019

Aims

The primary aim of the study was to perform an analysis to identify the cost per quality-adjusted life-year (QALY) of robot-assisted unicompartmental knee arthroplasty (rUKA) relative to manual total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) for patients with isolated medial compartment osteoarthritis (OA) of the knee. Secondary aims were to assess how case volume and length of hospital stay influenced the relative cost per QALY.

Patients and Methods

A Markov decision analysis was performed, using known parameters for costs, outcomes, implant survival, and mortality, to assess the cost-effectiveness of rUKA relative to manual TKA and UKA for patients with isolated medial compartment OA of the knee with a mean age of 65 years. The influence of case volume and shorter hospital stay were assessed.

Results

Using a model with an annual case volume of 100 patients, the cost per QALY of rUKA was £1395 and £1170 relative to TKA and UKA, respectively. The cost per QALY was influenced by case volume: a low-volume centre performing ten cases per year would achieve a cost per QALY of £7170 and £8604 relative to TKA and UKA. For a high-volume centre performing 200 rUKAs per year with a mean two-day length of stay, the cost per QALY would be £648; if performed as day-cases, the cost would be reduced to £364 relative to TKA. For a high-volume centre performing 200 rUKAs per year with a shorter length of stay of one day relative to manual UKA, the cost per QALY would be £574.

Conclusion

rUKA is a cost-effective alternative to manual TKA and UKA for patients with isolated medial compartment OA of the knee. The cost per QALY of rUKA decreased with reducing length of hospital stay and with increasing case volume, compared with TKA and UKA. Cite this article: Bone Joint J 2019;101-B:1063–1070.