bluuebunny/crossref_metadata_2025 huggingface dataset:
Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model
Authors: Kanne Celeste K. , Nebor Danitza , Pochron Mira , Oksenberg Donna , Sheehan Vivien A.
Published: June 2022

In sickle cell disease (SCD), higher whole blood viscosity is a risk factor for vaso-occlusive crisis, avascular necrosis, and proliferative retinopathy. Blood viscosity is strongly impacted by hemoglobin (Hb) levels and red blood cell (RBC) deformability. Voxelotor is a hemoglobin S (HbS) polymerization inhibitor with anti-sickling properties that increases the Hb affinity for oxygen, thereby reducing HbS polymerization. In clinical trials, voxelotor increased Hb by an average of 1g/dl, creating concern that this rise in Hb could increase viscosity, particularly when the drug was cleared. To investigate this potential rebound hyperviscosity effect, we treated SCD mice with GBT1118, a voxelotor analog, and stopped the treatment to determine the effect on blood viscosity and RBC deformability under a range of oxygen concentrations. GBT1118 treatment increased Hb, improved RBC deformability by increasing the elongation index under normoxic (EImax) and hypoxic conditions (EImin), and decreased the point of sickling (PoS) without increasing blood viscosity. The anti-sickling effects and improvement of RBC deformability balanced the effect of increased Hb such that there was no increase in blood viscosity. Forty-eight hours after ceasing GBT1118, Hb declined from the rise induced by treatment, viscosity did not increase, and EImin remained elevated compared to control animals. Hb and PoS were not different from control animals, suggesting a return to native oxygen affinity and clearance of the drug. RBC deformability did not return to baseline, suggesting some residual rheological improvement. These data suggest that concerns regarding viscosity rise above pre-treatment levels upon sudden cessation of voxelotor are not warranted.
Resistance Exercise in People With Stage-3 Chronic Kidney Disease: Effects of Training Frequency (Weekly Volume) on Measures of Muscle Wasting and Function
Authors: Geneen Louise J. , Kinsella Jodie , Zanotto Tobia , Naish Patrick F. , Mercer Thomas H.
Published: June 2022

Background: Resistance training (RT) is a proven anabolic intervention in people living with and without chronic kidney disease (CKD). To date, there is a dearth of knowledge regarding the dose-response relationship of RT in the non-dialysis dependent CKD population. Therefore, we aimed to explore the effects of RT frequency (weekly volume) on established measures of muscle wasting and function in CKD.

Methods: Twenty people with stage-3 CKD (CKD-3) were allocated to either a low frequency (one-session per week, RT1) or higher frequency (three-sessions per week, RT3) 12-week RT programme consisting of lower extremity strengthening exercises. The two RT programmes were not volume matched. Assessment outcomes before and after the intervention included measures of total and regional body composition, muscle size and architecture, strength, physical function, and uraemic symptoms.

Results: Significant improvements over time in muscle size and architecture, strength, physical function, and uraemic symptoms were observed for both RT1 and RT3. Compared to RT1, participants who performed RT3 showed greater increases in vastus lateralis (VL) anatomical cross-sectional area (30.8% vs. 13.2%, p < 0.001) and pennation angle (36.3% vs. 17.5%, p = 0.008) after 12 weeks. In either group, there were no significant changes over time in mid-VL fascicle length, nor in measures of total body composition and upper arm muscle strength.

Conclusion: Despite the group differences observed in the VL physiological adaptations, the strength and physical function responses, as well as the reductions of uraemic symptoms, were similar whether training once or thrice weekly. Therefore, performing RT just once per week may be an effective pre-habilitation strategy for people with CKD-3.
Effects of Acute Hypoxic Stress on Physiological and Hepatic Metabolic Responses of Triploid Rainbow Trout (Oncorhynchus mykiss)
Authors: Han Buying , Meng Yuqiong , Tian Haining , Li Changzhong , Li Yaopeng , Gongbao Caidan , Fan Wenyan , Ma Rui
Published: June 2022

This experiment simulated the hypoxic environment caused by actual production operations in fish farming (i.e., catching, gathering, transferring, and weighting) to study the effects of acute hypoxic conditions on the physiological and metabolic responses of triploid rainbow trout (O. mykiss). Two groups of fish weighting 590 g were sampled in the normoxia group (dissolved oxygen above 7 mg/L) and hypoxia group (dissolved oxygen ranged from 2 to 5 mg/L for 10 min). The results showed that 1) regarding stress response, hypoxia increased plasma levels of cortisol, heat shock protein 70 (HSP-70), lysozyme, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine phosphokinase (CPK); induced the expression of hepatic genes encoding nuclear factor erythroid 2 related factor 2 (Nrf2), interferon γ (IFN-γ) and interleukin-1β (IL-1β). 2) Regarding metabolism response, hypoxia increased plasma levels of globulin (GLOB), glucose (GLU), triglyceride (TG) and lactate dehydrogenase (LDH); upregulated the hepatic gene expression of phosphoenolpyruvate carboxykinase, (PEPCK), pyruvate dehydrogenase kinase (PDK1), acetyl-CoA carboxylase (ACC) and acetyl-CoA oxidase (ACO); downregulated the hepatic gene expression of carnitine palmitoyl transferase 1 (CPT1); and unchanged the expression of hepatic genes in glycolysis and autophagy. 3) In response to hypoxia-inducible factors (HIFs), the hepatic HIF-2α gene was activated in the hypoxia group, but HIF-1α gene expression remained unchanged. Thus, during acute hypoxic stress, triploid rainbow trout were in a defensive state, with an enhanced immune response and altered antioxidant status. Additionally, the hepatic mitochondrial oxidation of glucose- and lipid-derived carbon in trout was suppressed, and hepatic gluconeogenesis and lipid synthesis were activated, which might be regulated by the HIF-2α pathway.
Changes of Gene Expression Patterns of Muscle Pathophysiology-Related Transcription Factors During Denervated Muscle Atrophy
Authors: Yang Xiaoming , Li Ming , Ji Yanan , Lin Yinghao , Xu Lai , Gu Xiaosong , Sun Hualin , Wang Wei , Shen Yuntian , Liu Hua , Zhu Jianwei
Published: June 2022

Peripheral nerve injury is common, and can lead to skeletal muscle atrophy and dysfunction. However, the underlying molecular mechanisms are not fully understood. The transcription factors have been proved to play a key role in denervated muscle atrophy. In order to systematically analyze transcription factors and obtain more comprehensive information of the molecular regulatory mechanisms in denervated muscle atrophy, a new transcriptome survey focused on transcription factors are warranted. In the current study, we used microarray to identify and analyze differentially expressed genes encoding transcription factors in denervated muscle atrophy in a rat model of sciatic nerve dissection. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to explore the biological functions of differentially expressed transcription factors and their target genes related to skeletal muscle pathophysiology. We found that the differentially expressed transcription factors were mainly involved in the immune response. Based on correlation analysis and the expression trends of transcription factors, 18 differentially expressed transcription factors were identified. Stat3, Myod1, Runx1, Atf3, Junb, Runx2, Myf6, Stat5a, Tead4, Klf5, Myog, Mef2a, and Hes6 were upregulated. Ppargc1a, Nr4a1, Lhx2, Ppara, and Rxrg were downregulated. Functional network mapping revealed that these transcription factors are mainly involved in inflammation, development, aging, proteolysis, differentiation, regeneration, autophagy, oxidative stress, atrophy, and ubiquitination. These findings may help understand the regulatory mechanisms of denervated muscle atrophy and provide potential targets for future therapeutic interventions for muscle atrophy following peripheral nerve injury.
Genetic Potential and Inheritance Pattern of Phenological Growth and Drought Tolerance in Cotton (Gossypium Hirsutum L.)
Authors: Mahmood Tahir , Wang Xiukang , Ahmar Sunny , Abdullah Muhammad , Iqbal Muhammad Shahid , Rana Rashid Mehmood , Yasir Muhammad , Khalid Shiguftah , Javed Talha , Mora-Poblete Freddy , Chen Jen-Tsung , Shah Muhammad Kausar Nawaz , Du Xiongming
Published: June 2022

Cotton has prime importance in the global economy and governs socio-economic affairs of the world. Water scarcity and high temperature are major constraints that badly affect cotton production, which shows the need for the development of drought-tolerant varieties. Ten cotton genotypes, including three drought-tolerant and seven susceptible, were identified from a panel of diverse cotton genotypes at the seedling stage under two contrasting water regimes. Three lines were crossed with seven testers under line × tester mating design. The 21 F1 cross combinations along with 10 parents were evaluated under 100% non-stress (NS) and 50% drought stress (DS) filed capacity to assess the effects of drought stress and its inheritance in the next generation. All the genotypes were evaluated till the maturity stage for combining ability, heritability, and other genetic factors to understand the drought tolerance mechanisms. The proportional contribution of lines in the total variance evidenced that lines had a significant higher contribution in total variance for days to boll opening (DBO) of 10% and proline contents (PC) of 13% under DS conditions. It indicates that lines contributed more positive alleles for such traits. Under DS condition, DTV-9 × BT-252 and DTV-9 × DTV-10 had maximum negative specific combining ability (SCA) effects for DBO. Simultaneously, DBO also had higher heritability (h2) which indicates its dominant gene action and meanwhile, the importance of these combinations for the early mature and short duration variety development. The results revealed that most of the studied traits, including days taken to maturity, yield traits, and physiological traits, are under significant genetic control, with a strong genetic basis and have a huge potential for improving drought tolerance in cotton. Drought tolerance was found to have a strong association with early maturity and agro-climatic conditions of the cultivated areas. Identified superior parents in this study are suggested to use in the future breeding program to advance the cotton growth and drought tolerance.
Comparative Analysis of Chloroplast Genome and New Insights Into Phylogenetic Relationships of Polygonatum and Tribe Polygonateae
Authors: Wang Jing , Qian Jun , Jiang Yuan , Chen Xiaochen , Zheng Baojiang , Chen Shilin , Yang Fajian , Xu Zhichao , Duan Baozhong
Published: June 2022

Members of Polygonatum are perennial herbs that have been widely used in traditional Chinese medicine to invigorate Qi, moisten the lung, and benefit the kidney and spleen among patients. However, the phylogenetic relationships and intrageneric taxonomy within Polygonatum have long been controversial because of the complexity of their morphological variations and lack of high-resolution molecular markers. The chloroplast (cp) genome is an optimal model for deciphering phylogenetic relationships in related families. In the present study, the complete cp genome of 26 species of Trib. Polygonateae were de novo assembled and characterized; all species exhibited a conserved quadripartite structure, that is, two inverted repeats (IR) containing most of the ribosomal RNA genes, and two unique regions, large single sequence (LSC) and small single sequence (SSC). A total of 8 highly variable regions (rps16-trnQ-UUG, trnS-GCU-trnG-UCC, rpl32-trnL-UAG, matK-rps16, petA-psbJ, trnT-UGU-trnL-UAA, accD-psaI, and trnC-GCA-petN) that might be useful as potential molecular markers for identifying Polygonatum species were identified. The molecular clock analysis results showed that the divergence time of Polygonatum might occur at ∼14.71 Ma, and the verticillate leaf might be the ancestral state of this genus. Moreover, phylogenetic analysis based on 88 cp genomes strongly supported the monophyly of Polygonatum. The phylogenetic analysis also suggested that Heteropolygonatum may be the sister group of the Polygonatum, but the Disporopsis, Maianthemum, and Disporum may have diverged earlier. This study provides valuable information for further species identification, evolution, and phylogenetic research of Polygonatum.
Network and Evolutionary Analysis Reveals Candidate Genes of Membrane Trafficking Involved in Maize Seed Development and Immune Response
Authors: Zheng Chunyan , Yu Yin , Deng Guiling , Li Hanjie , Li Faqiang
Published: June 2022

The plant membrane-trafficking system plays a crucial role in maintaining proper cellular functions and responding to various developmental and environmental cues. Thus far, our knowledge of the maize membrane-trafficking system is still limited. In this study, we systematically identified 479 membrane-trafficking genes from the maize genome using orthology search and studied their functions by integrating transcriptome and evolution analyses. These genes encode the components of coated vesicles, AP complexes, autophagy, ESCRTs, retromers, Rab GTPases, tethering factors, and SNAREs. The maize genes exhibited diverse but coordinated expression patterns, with 249 genes showing elevated expression in reproductive tissues. Further WGCNA analysis revealed that five COPII components and four Rab GTPases had high connectivity with protein biosynthesis during endosperm development and that eight components of autophagy, ESCRT, Rab, and SNARE were strongly co-upregulated with defense-related genes and/or with secondary metabolic processes to confer basal resistance to Fusarium graminearum. In addition, we identified 39 membrane-trafficking genes with strong selection signals during maize domestication and/or improvement. Among them, ZmSec23a and ZmVPS37A were selected for kernel oil production during improvement and pathogen resistance during domestication, respectively. In summary, these findings will provide important hints for future appreciation of the functions of membrane-trafficking genes in maize.
Comparison of Remote Sensing Methods for Plant Heights in Agricultural Fields Using Unmanned Aerial Vehicle-Based Structure From Motion
Authors: Fujiwara Ryo , Kikawada Tomohiro , Sato Hisashi , Akiyama Yukio
Published: June 2022

Remote sensing using unmanned aerial vehicles (UAVs) and structure from motion (SfM) is useful for the sustainable and cost-effective management of agricultural fields. Ground control points (GCPs) are typically used for the high-precision monitoring of plant height (PH). Additionally, a secondary UAV flight is necessary when off-season images are processed to obtain the ground altitude (GA). In this study, four variables, namely, camera angles, real-time kinematic (RTK), GCPs, and methods for GA, were compared with the predictive performance of maize PH. Linear regression models for PH prediction were validated using training data from different targets on different flights (“different-targets-and-different-flight” cross-validation). PH prediction using UAV-SfM at a camera angle of –60° with RTK, GCPs, and GA obtained from an off-season flight scored a high coefficient of determination and a low mean absolute error (MAE) for validation data (R2val = 0.766, MAE = 0.039 m in the vegetative stage; R2val = 0.803, MAE = 0.063 m in the reproductive stage). The low-cost case (LC) method, conducted at a camera angle of –60° without RTK, GCPs, or an extra off-season flight, achieved comparable predictive performance (R2val = 0.794, MAE = 0.036 m in the vegetative stage; R2val = 0.749, MAE = 0.072 m in the reproductive stage), suggesting that this method can achieve low-cost and high-precision PH monitoring.
A Vegetable Leaf Disease Identification Model Based on Image-Text Cross-Modal Feature Fusion
Authors: Feng Xuguang , Zhao Chunjiang , Wang Chunshan , Wu Huarui , Miao Yisheng , Zhang Jingjian
Published: June 2022

In view of the differences in appearance and the complex backgrounds of crop diseases, automatic identification of field diseases is an extremely challenging topic in smart agriculture. To address this challenge, a popular approach is to design a Deep Convolutional Neural Network (DCNN) model that extracts visual disease features in the images and then identifies the diseases based on the extracted features. This approach performs well under simple background conditions, but has low accuracy and poor robustness under complex backgrounds. In this paper, an end-to-end disease identification model composed of a disease-spot region detector and a disease classifier (YOLOv5s + BiCMT) was proposed. Specifically, the YOLOv5s network was used to detect the disease-spot regions so as to provide a regional attention mechanism to facilitate the disease identification task of the classifier. For the classifier, a Bidirectional Cross-Modal Transformer (BiCMT) model combining the image and text modal information was constructed, which utilizes the correlation and complementarity between the features of the two modalities to achieve the fusion and recognition of disease features. Meanwhile, the problem of inconsistent lengths among different modal data sequences was solved. Eventually, the YOLOv5s + BiCMT model achieved the optimal results on a small dataset. Its Accuracy, Precision, Sensitivity, and Specificity reached 99.23, 97.37, 97.54, and 99.54%, respectively. This paper proves that the bidirectional cross-modal feature fusion by combining disease images and texts is an effective method to identify vegetable diseases in field environments.
Belowground Carbon Efficiency for Nitrogen and Phosphorus Acquisition Varies Between Lolium perenne and Trifolium repens and Depends on Phosphorus Fertilization
Authors: Lu Jiayu , Yang Jinfeng , Keitel Claudia , Yin Liming , Wang Peng , Cheng Weixin , Dijkstra Feike A.
Published: June 2022

Photosynthetically derived carbon (C) is allocated belowground, allowing plants to obtain nutrients. However, less is known about the amount of nutrients acquired relative to the C allocated belowground, which is referred to as C efficiency for nutrient acquisition (CENA). Here, we examined how C efficiency for nitrogen (N) and phosphorus (P) acquisition varied between ryegrass (Lolium perenne) and clover (Trifolium repens) with and without P fertilization. A continuous 13C-labeling method was applied to track belowground C allocation. Both species allocated nearly half of belowground C to rhizosphere respiration (49%), followed by root biomass (37%), and rhizodeposition (14%). With regard to N and P, CENA was higher for clover than for ryegrass, which remained higher after accounting for relatively low C costs associated with biological N2 fixation. Phosphorus fertilization increased the C efficiency for P acquisition but decreased the C efficiency for N acquisition. A higher CENA for N and P in clover may be attributed to the greater rhizosphere priming on soil organic matter decomposition. Increased P availability with P fertilization could induce lower C allocation for P uptake but exacerbate soil N limitation, thereby making N uptake less C efficient. Overall, our study revealed that species-specific belowground C allocation and nutrient uptake efficiency depend on which nutrient is limited.
Analyses on Flavonoids and Transcriptome Reveals Key MYB Gene for Proanthocyanidins Regulation in Onobrychis Viciifolia
Authors: Jin Zhongzhiyue , Jiang Wenbo , Luo Yijing , Huang Haijun , Yi Dengxia , Pang Yongzhen
Published: June 2022

Onobrychis viciifolia (sainfoin) is one of the most high-quality legume forages, which is rich in proanthocyanidins that is beneficial for the health and production of animals. In this study, proanthocyanidins and total flavonoids in leaves of 46 different sainfoin germplasm resources were evaluated, and it showed that soluble proanthocyanidin contents varied greatly in these sainfoin germplasm resources, but total flavonoids did not show significant difference. Transcriptome sequencing with high and low proanthocyanidins sainfoin resulted in the identification of totally 52,926 unigenes in sainfoin, and they were classed into different GOC categories. Among them, 1,608 unigenes were differentially expressed in high and low proanthocyanidins sainfoin samples, including 1,160 genes that were upregulated and 448 genes that were downregulated. Analysis on gene enrichment via KEGG annotation revealed that the differentially expressed genes were mainly enriched in the phenylpropanoid biosynthetic pathway and the secondary metabolism pathway. We also analyzed the expression levels of structural genes of the proanthocyanidin/flavonoid pathway in roots, stems, and leaves in the high proanthocyanidin sainfoin via RT-qPCR and found that these genes were differentially expressed in these tissues. Among them, the expression levels of F3'5'H and ANR were higher in leaves than in roots or stems, which is consistent with proanthocyanidins content in these tissues. Among MYB genes that were differentially expressed, the expression of OvMYBPA2 was relatively high in high proanthocyanidin sainfoin. Over-expression level of OvMYBPA2 in alfalfa hairy roots resulted in decreased anthocyanin content but increased proanthocyanidin content. Our study provided transcriptome information for further functional characterization of proanthocyanidin biosynthesis-related genes in sainfoin and candidate key MYB genes for bioengineering of proanthocyanidins in plants.
Catch the Open! A Gamified Interactive Immersion Into Open Educational Practices for Higher Education Educators
Authors: Padilla-Zea Natalia , Burgos Daniel , García-Holgado Alicia , García-Peñalvo Francisco José , Harquevaux Mélanie Pauline , de-la-Higuera Colin , Brunton James , Tlili Ahmed
Published: June 2022

Open Education (OE) opens up learning opportunities to, potentially, every person in the world. Additionally, it allows teachers, researchers, and practitioners to find, share, reuse, and improve existing resources under a dependable legal framework. Aiming to spread and foster the introduction of open policies in Higher Education (HE) institutions, the gamified interactive learning experienceCatch the Open!was developed.Catch the Open!targets HE educators who wish to learn, or who wish to deepen their existing knowledge, about OE and Open Educational Practices (OEP). Within the gamified learning experience, the user becomes an educator, Alex, the game character, who receives a task from the Rector: to investigate how to best include OE and OEP in teaching and learning practice within the institution. Alex proceeds to explore and gather information in a web-based 2D virtual HE institution where students, colleagues, and guest researchers will help her to develop a comprehensive understanding of OE and the practical application of OEP. The educational content withinCatch the Open!is underpinned by an OE competences framework for HE educators, developed in a previous phase of the Erasmus+ OpenGame project. In this paper, the design process to link pedagogical and technological approaches, which results in theCatch the Open!gamified web-based interactive application, is presented as well as the application itself. Moreover, two phases of piloting with 153 HE educators from six different HE institutions are presented. The obtained findings showed that the gamified environment helped in learning about OE. On the other hand, learners also suggested several improvement aspects of the gamified environment, such as the length of finishing a learning mission while playing.
Classical Music Students’ Pre-performance Anxiety, Catastrophizing, and Bodily Complaints Vary by Age, Gender, and Instrument and Predict Self-Rated Performance Quality
Authors: Sokoli Erinë , Hildebrandt Horst , Gomez Patrick
Published: June 2022

Music performance anxiety (MPA) is a multifaceted phenomenon occurring on a continuum of severity. In this survey study, we investigated to what extent the affective (anxiety), cognitive (catastrophizing), and somatic (bodily complaints) components of MPA prior to solo performances vary as a function of age, gender, instrument group, musical experience, and practice as well as how these MPA components relate to self-rated change in performance quality from practice to public performance. The sample comprised 75 male and 111 female classical music university students, aged 15–45 years. Age was positively associated with anxious feelings and bodily complaints. Compared to male students, female students reported significantly more anxious feelings and catastrophizing. Singers reported less anxious feelings and catastrophizing than instrumentalists. Breathing-, mouth- and throat-related complaints were highest among singers and wind players; hand- and arm-related complaints were highest among string players and pianists. The indices of musical experience and practice had marginal effects. An average of four bodily complaints bothered the participants strongly to very strongly. Worsening in performance quality from practice to public performance was reported by almost half of the participants and was best predicted by anxious feelings and breathing-related complaints. We conclude that age, gender and instrument play a significant role in understanding the phenomenology of MPA. Musicians should be examined according to these characteristics rather than as one homogenous population. In particular, it might be valuable to develop assessment tools for MPA that incorporate items related to the bodily complaints that are most relevant to the different instrument groups. Breathing-related complaints could add an important dimension to the investigation of MPA and music performance. Finally, the high percentage of students reporting worsening of their performance quality from practice to public performance highlights the need of professional support to help music students be able to perform at their best and thrive as artists.
The Nuance of Bilingualism as a Reserve Contributor: Conveying Research to the Broader Neuroscience Community
Authors: Voits Toms , DeLuca Vincent , Abutalebi Jubin
Published: June 2022

The neurological notion of “reserve” arises from an individually observable dissociation between brain health and cognitive status. According to the cognitive reserve hypothesis, high-reserve individuals experience functional compensation for neural atrophy and, thus, are able to maintain relatively stable cognitive functioning with no or smaller-than-expected impairment. Several lifestyle factors such as regular physical exercise, adequate and balanced nutrition, and educational attainment have been widely reported to contribute to reserve and, thus, lead to more successful trajectories of cognitive aging (CA). In recent years, it has become clear that bilingualism is also a potential reserve contributor. Yet, there is little communication between the neuroscience of bilingualism research community and researchers working in the field of CA more generally, despite compelling reasons for it. In fact, bilingualism tends to be overlooked as a contributory factor in the CA literature, or reduced to a dichotomous trait, despite it being a complex experience. Herein, we discuss issues that are preventing recognition of bilingualism as a reserve contributor across all literatures, highlight the benefits of including language experiences as a factor of interest across research disciplines, and suggest a roadmap to better integrate bilingualism and aging moving forward. We close with calls toward a model of aging that examines the contributions across lifestyle factors, including that of bilingual experience.
Predicting the Factors of Employee Agility Using Enterprise Social Media: The Moderating Role of Innovation Culture
Authors: Zhang Luteng , Xu Yan , Chen Chunchun , Zhao Rui
Published: June 2022

This study aims to create a research model that examines how employee agility is affected by enterprise social media usage (ESMU), and to discuss the moderating role of innovation culture in communication quality, trust, and employee agility using the relational capital theory. Data of 477 Chinese employees from different companies were collected in this study for analysis, and the hypotheses developed were examined. The purpose of this study was to explore the influence mechanism that propels employees’ ESMU, communication quality and trust and the moderating effect of innovation culture. This study conducts PLS-SEM to analyze collected data. The results show that ESMU is positively associated with communication quality and trust; innovation culture plays a positive moderating role in ESMU and employee agility; and high communication quality and trust can lead to high agility. However, innovation culture does not have a remarkable moderating effect on ESMU and communication quality. This study offers empirical evidence on how the effect of ESMU on employee agility is transferred by innovation culture. In addition, the benefits of enterprise social media for organizational management are also measured in this study, which may motivate the managements to introduce enterprise social media in work spaces.
Exploring Climate Emotions in Canada’s Provincial North
Authors: Galway Lindsay P. , Beery Thomas
Published: June 2022

The mental and emotional dimensions of climate change are increasingly concerning as extreme events become more frequent and severe, ecosystem destruction advances, and people become more aware of climate impacts and injustices. Research on climate emotions has rapidly advanced over the last decade with growing evidence illustrating that climate emotions can impact health, shape climate action, and ought to be considered in climate change communication, education, and engagement. This paper explores, describes, and discusses climate emotions in the context of Canada’s Provincial North: a vast region characterized by a vulnerability to climate change, remoteness, political marginalization, diverse Indigenous populations, and economies/livelihoods tied to resource extraction. Using postal survey data collected in two Provincial North communities (Thunder Bay, Ontario, and Prince George, British Columbia;N= 627), we aim to (1) describe climate emotions experienced in the context of Canada’s Provincial North, including relationships among specific emotions; and (2) examine if socio-demographic variables (gender, age, and parenthood) show a relationship with climate emotions. Results show high levels of emotional response to climate change overall, with worry and frustration as those emotions reported by the highest percentage of participants. We also find significant difference in climate emotions between men and women. A methodological result was noted in the usefulness of the Climate Emotion Scale (CES), which showed high reliability and high inter-item correlation. A notable limitation of our data is its’ underrepresentation of Indigenous peoples. The findings contribute to a greater understanding of climate emotions with relevance to similar settings characterized by marginalization, vulnerability to climate change, urban islands within vast rural and remote landscapes, and economies and social identities tied to resource extraction. We discuss our findings in relation to the literature and outline future research directions and implications.
Posttraumatic Growth, Positive Psychology, Perceived Spousal Support, and Psychological Complications in Head and Neck Cancer: Evaluating Their Association in a Longitudinal Study
Authors: Nik Jaafar Nik Ruzyanei , Abd Hamid Norhaliza , Hamdan Nur Amirah , Rajandram Rama Krsna , Mahadevan Raynuha , Mohamad Yunus Mohd Razif , Zakaria Hazli , Mohd Shariff Noorsuzana , Hami Rohayu , Isa Salbiah , Shari Nurul Izzah , Leong Bin Abdullah Mohammad Farris Iman
Published: June 2022

Despite head and neck cancer (HNC) association with various negative impacts, collective evidence is accumulating regarding the positive impacts of positive psychology on cancer survivors. However, data on how positive psychology is related to the psychological complications of HNC across time are lacking. This longitudinal study examined the trends of positive psychology (e.g., posttraumatic growth [PTG], hope, and optimism), perceived spousal support, and psychological complications (e.g., depression, anxiety, and posttraumatic stress symptoms) and determined the association between them, psychological complications, and PTG across two timelines among a cohort of HNC patients. A total of 175 HNC respondents exhibited an increasing trend of positive psychology and perceived spousal support while reporting a decreasing trend of psychological complications between baseline and follow-up assessments. A greater degree of hope and perceived spousal support contributed to a higher degree of PTG across time. Conversely, a higher severity of anxiety symptoms was associated with a lower degree of PTG over time. Female gender had a moderating effect on the association between severity of anxiety symptoms and PTG, but did not moderate the association between hope, perceived spousal support and PTG. This study indicates the pivotal role of incorporating psychosocial interventions into the treatment regimen to enhance the degree of hope and perceived spousal support and reduce the severity of anxiety symptoms, which, in turn, will facilitate the development of PTG in HNC patients.
The Role of EFL/ESL Teachers’ Psychological Empowerment and Optimism on Their Job Commitment
Authors: Xiong Xiaoqin
Published: June 2022

Research has approved that teaching is a complex profession involving many cognitive, social, cultural, and psycho-emotional factors. To perform efficiently, teachers must be psycho-emotionally powerful and ready to cope with the existing challenges and complications of teaching a second/foreign language. This demands attempts to be made to psychologically empower the teachers to form positive outlooks about their profession and practices. Despite the criticality of psychological empowerment (PE), few studies in L2 contexts have dealt with it. Against this gap, the present article aimed to theoretically analyze the interaction among teachers’ PE, optimism, and commitment. In so doing, the definitions, models, components, typologies, and empirical studies related to these constructs were presented. Finally, practical implications of this line of research for EFL/ESL teachers, teacher trainers, and researchers are provided to raise their awareness of psycho-emotional factors involved L2 education.
COVID-19-Related Psychosocial Care in General Hospitals: Results of an Online Survey of Psychosomatic, Psychiatric, and Psychological Consultation and Liaison Services in Germany, Austria, and Switzerland
Authors: Schaefert Rainer , Stein Barbara , Meinlschmidt Gunther , Roemmel Noa , Huber Christian G. , Hepp Urs , Saillant Stéphane , Fazekas Christian , Vitinius Frank
Published: June 2022

Background

The coronavirus disease 2019 (COVID-19) pandemic was accompanied by new challenges for psychosocial health care to enable the support of affected patients, their families, and staff in general hospitals. In this study, we aimed to describe the structures and procedures put in place by psychosomatic, psychiatric, and psychological consultation and liaison (CL) services in German, Austrian, and Swiss general hospitals, and to elucidate the emerging needs for cooperation, networking, and improvement.

Methods

We conducted a cross-sectional online survey between December 2020 and May 2021, using a 25-item questionnaire derived from relevant literature, professional experience, and consultation with the participating professional societies. The survey was disseminated via national professional societies, relevant working and interest groups, and heads of the above-mentioned CL services.

Results

We included responses from 98 CL services in the analyses, with a total response rate of 55% of surveyed hospital CL services; 52 responses originated from Germany, 20 from Austria, and 26 from Switzerland. A total of 77 (79%) of the 98 responding CL services reported that “COVID-19-related psychosocial care” (COVID-psyCare) was provided in their hospital. Among these, 47 CL services (61%) indicated that specific cooperation structures for COVID-psyCare had been established within the hospital. A total of 26 CL services (34%) reported providing specific COVID-psyCare for patients, 19 (25%) for relatives, and 46 (60%) for staff, with 61, 12, and 27% of time resources invested for these target groups, respectively. Regarding emerging needs, 37 (48%) CL services expressed wishes for mutual exchange and support regarding COVID-psyCare, and 39 (51%) suggested future changes or improvements that they considered essential.

Conclusion

More than three-quarters of the participating CL services provided COVID-psyCare for patients, their relatives, or staff. The high prevalence of COVID-psyCare services targeting hospital staff emphasizes the liaison function of CL services and indicates the increased psychosocial strain on health care personnel during the COVID-19 pandemic. Future development of COVID-psyCare warrants intensified intra- and interinstitutional exchange and support.

Trial Registration

ClinicalTrials.gov NCT04753242, version 11 February 2021.
Impacts of Regional Speed Control Strategy Based on Macroscopic Fundamental Diagram on Energy Consumption and Traffic Emissions: A Case Study of Beijing
Authors: Wang Wensi , Wang Zirui , Wang Guangjun , Yu Bin , Xu Yuhe , Yu Kun
Published: June 2022

Numerous studies shown that particulate matter in the ambient environment has a significant impact on the health of the respiratory system. To understand the interrelationships between urban built environment, transportation operations and health, this study proposes an innovative approach that uses real-world GPS datasets to calculate energy consumption and emissions from transportation. The experiment used the traffic operation state in the Fourth Ring Road of Beijing as the research object and tested the impact of using the Regional speed optimization (RSO) strategy based on Macroscopic Fundamental Diagram (MFD) on energy consumption and emissions during peak hours. The impact of traffic emission on the health of roadside pedestrians is also considered. Changes in PM2.5 concentrations around four different built-up areas were calculated and compared. The computational experiments indicate that the PM2.5 pollutants exhausted by the traffic on the Ring Road during peak hours can reach up to 250 μg/m3, while the traffic emission on general roads near residential areas is only 50 μg/m3. Adopting Regional speed optimization can reduce the energy consumption of the road network by up to 18.8%. For roadside runners, the PM2.5 inhalation caused by night running in commercial and recreational areas is about 1.3-2.6 times that of night running in residential areas. Compared with morning or night running, the risk of respiratory disease caused by PM2.5 inhalation was about 10.3% higher than commuter running behavior. The research results provide a useful reference for energy conservation and emission reduction control strategies for different road types in cities and help existing cities to establish a traveler health evaluation system caused by traffic operation.
The Association Between 2, 4-Dichlorophenoxyacetic Acid and Erectile Dysfunction
Authors: Wang Wei , Ma Yucheng , Chen Jiawei , Peng Liao , Gao Xiaoshuai , Lin Lede , Zhang Fuxun , Xiong Yang , Qin Feng , Yuan Jiuhong
Published: June 2022

Background

2, 4-dichlorophenoxyacetic acid (2,4-D) is one of the most frequently used herbicides in the world, and it has been linked with low testosterone; however, studies regarding its effect on erectile function are limited. The current study aimed to determine the association between the 2,4-D exposure and erectile dysfunction (ED) in men from the National Health and Nutrition Examination Survey (NHANES).

Methods

We analyzed data for urinary 2,4-D levels from 1,311 men (>20 years of age) in the NHANES 2001–2004. ED was assessed by a single, validated survey question. Multivariable logistic regression analysis utilizing sampling weights was performed to determine the relationship between 2,4-D exposure and ED.

Results

Multivariable logistic regression models demonstrated no statistically significant association between 2,4-D exposure and ED after full adjustment [odds ratio (OR) 1.02; 95% CI 0.77–1.36; P = 0.882)]. Men in the 2,4-D quartile 4 groups were not associated with an increased risk of ED (OR 1.13; 95% CI 0.74–1.75; P for trend = 0.481). Furthermore, the association between urinary 2,4-D level and ED was not significant in the subgroup analysis stratified by age, BMI, cardiovascular disease, hypertension, diabetes, and high cholesterol.

Conclusion

We demonstrated that there was no association between 2,4-D exposure and ED. Further studies are warranted to corroborate our results.
Emergency Teleradiology-Past, Present, and, Is There a Future?
Authors: Agrawal Anjali
Published: June 2022

Emergency radiology has evolved into a distinct radiology subspecialty requiring a specialized skillset to make a timely and accurate diagnosis of acutely and critically ill or traumatized patients. The need for emergency and odd hour radiology coverage fuelled the growth of internal and external teleradiology and the “nighthawk” services to meet the increasing demands from all stakeholders and support the changing trends in emergency medicine and trauma surgery inclined toward increased reliance on imaging. However, the basic issues of increased imaging workload, radiologist demand-supply mismatch, complex imaging protocols are only partially addressed by teleradiology with the promise of workload balancing by operations to scale. Incorporation of artificially intelligent tools helps scale manifold by the promise of streamlining the workflow, improved detection and quantification as well as prediction. The future of emergency teleradiologists and teleradiology groups is entwined with their ability to incorporate such tools at scale and adapt to newer workflows and different roles. This agility to adopt and adapt would determine their future.
Spatial Variability of In Situ Above-Water Reflectance in Coastal Dynamic Waters: Implications for Satellite Match-Up Analysis
Authors: Nasiha Hussain J. , Wang Ziwei , Giannini Fernanda , Costa Maycira
Published: June 2022

The validation of ocean color satellite retrievals generally relies on analyzing match-ups between in situ measurements and satellite retrievals. These analyses focus on the quality of the satellite data, however, of the same importance is the quality of the in situ data. Here, we present the spatial variability of in situ above-water reflectance (Rrs(0+)) within the spatial resolution of different ocean color satellites—300, 900, 1500, and 3000 m spatial resolutions, mimicking Sentinel 3 OLCI and MODIS-Aqua satellites, and possible 3 × 3 and 5 × 5 windows. Radiometric data was acquired with autonomous radiometric sensors installed in the British Columbia Ferry Services Inc. vessel “Queen of Alberni” from May to September 2019, crossing the optically dynamic waters of the Strait of Georgia, Canada. The dataset followed optimal geometry of acquisition and processing, including corrections for skylight radiance signals, ship superstructure, the non-isotropic distribution of the water-leaving radiances, and quality control. A total of 33,073 spectra at full resolution, corresponding to 10 days, were considered for the analysis presented here. The results showed that, overall, the subpixel variability increased as the spatial resolution of the sensor or the window size increased, mainly in a linear fashion. Specifically, spatial variability of Rrs(0+) was the largest (∼18% and 68% for 900 and 3000 m pixel resolution, respectively) in Near Field Plume Interface waters, followed by in the Ocean Water Interface (∼28% and 35%, respectively), thus indicating spatial heterogeneity of interface waters. Further, we found that the estuarine waters showed higher subpixel Rrs(0+) variability (∼8% and 16% for 900 and 3000 m, respectively) compared with plume and oceanic waters. We showed that the high spatial variability in Rrs(0+) was primarily associated with the spatial dynamics of the optical water constituents, thus limiting the use of these datasets as Fiducial Reference Measurements and for validation of satellite-derived atmospherically corrected reflectance. We suggest that spatial variability of the in situ Rrs(0+) should also be considered in the selection criteria for good match-up data, especially for data acquired in coastal dynamic systems. As a result, it will advocate for the exclusion of interface or transition water pixel grids in order to avoid compromising the statistical result of satellite validation.
Concurrent Validity of Movement Screening Criteria Designed to Identify Injury Risk Factors in Adolescent Female Volleyball Players
Authors: Ulman Sophia , Erdman Ashley , Loewen Alex , Dressing Michael , Wyatt Charles , Oliver Gretchen , Butler Lauren , Sugimoto Dai , Black Amanda M. , Janosky Joseph
Published: June 2022

Anterior cruciate ligament (ACL) injuries in female adolescent athletes occur at disproportionately high levels compared to their male counterparts. However, limited prospective data exist on the validity of low-cost screening tools that can proactively identify ACL injury risk, specifically for female athletes. The purpose of this study was to assess the concurrent validity of a three-task injury risk factor assessment by comparing visually derived outcome scores from two-dimensional (2D) video data with dichotomized three-dimensional (3D) biomechanical variables collected using motion capture technology. A total of 41 female club volleyball athletes (14.7 ± 1.4 years) were tested and asked to perform three tasks: double-leg vertical jump (DLVJ), single-leg squat (SLS), and single-leg drop landing (SLDL). One rater was trained on the scoring criteria for the 2D data and independently scored one forward-facing and one side-facing video for each task. Risk factors identified included poor knee position, lateral trunk lean, and excessive trunk flexion/extension. In addition, 3D joint angles were calculated for the trunk and knee in the sagittal and frontal planes and converted to dichotomous variables based on biomechanical thresholds of injury risk. For comparison of 2D and 3D outcomes, percent agreement and Cohen's kappa were calculated for each risk factor individually. Overall, 2D scores were found to exhibit moderate to excellent percent agreement with 3D outcomes for trunk position (69.1–97.1%). Specifically, ipsilateral trunk lean during single-leg tasks exhibited the highest agreement (85.3–88.2%) with moderate reliability (κ = 0.452–0.465). In addition, moderate to substantial reliability was found for trunk flexion during double-leg tasks (κ = 0.521–0.653); however, an evaluation of single-leg tasks resulted in only fair reliability (κ = 0.354). Furthermore, 2D scores were not successful in identifying poor knee position as percent agreement fell below 50% for both the single-leg tasks and averaged 60% agreement across both the phases of the DLVJ. Kappa coefficients further emphasized these trends indicating no to slight concurrent validity (κ = −0.047–0.167) across tasks. Overall, these findings emphasize the potential for valid, low-cost screening tools that can identify high-risk movement patterns. Further study is needed to develop improved assessment guidelines that may be employed through visual assessment in sports environments.