bluuebunny/crossref_metadata_2025 huggingface dataset:
Newton's Second Law Revisited: Accounting for Resistance in Applied Forces
Authors: Nafria Amritpal Singh
Published: January 2024

This article traces the historical evolution of applied force equation from its origins with Aristotle to the widespread recognition of Sir Isaac Newton's foundational equation, 'F=ma'. The contributions of influential figures such as John Philoponus, Avicenna, and John Buridan are explored, highlighting the progression of our understanding of applied forces over time. The central insight of this study revolves around the conventional equation 'F=ma', which, while fundamental, lacks consideration of resistance forces encountered in real-world scenarios. This paper aims to consider both the force applied to an object and any opposing resistance forces it experiences. The proposed equation (F=ma+r) emphasizes that an applied force not only causes acceleration but must also overcome resistance forces to achieve that acceleration. This equation offers a more complete model for practical scenarios. Additionally, the suggested method for measuring resistance forces adds to its real-world utility. It highlights how science continually evolves to better describe the complexities of the physical world.
Get3 in Arabidopsis
Authors:   , Bodensohn Uwe
Published: January 2024

The guided entry of tail-anchored proteins (GET) pathway mediates the targeting and insertion of tail-anchored proteins into the lipid bilayer of the endoplasmic reticulum (ER). A highly regulated protein triage hands over the TA protein from a pre-targeting complex composed of Sgt2 and Get4/5 to the receptor complex comprised of Get1/2 in a Get3 dependent manner. Previous studies have identified that, Get3 the central ATPase of the pathway, has three orthologues in Arabidopsis thaliana. These belong to two different conserved clades, namely an “a” clade and a “bc” clade localized to the cytosol and endosymbiotic-originated organelles, respectively. Here, the taxonomic relationship of Get3 in planta was re-evaluated and identified groups orthologous to the cytosolic (AtGet3a), plastidic (AtGet3b) and mitochondrial (AtGet3c) as well as a fourth Poales specific orthologous group (SBGet3). The localizations of the former three groups were evaluated in selected homologous as well as heterologous systems and displayed that several Get3 orthologues with divergent localizations is communal in plants. However, knowledge of the function of these proteins is still limited. For this, I could identify putative elements of the pre-targeting complex and establish two systems to functionally characterize AtGet3a. One to (i) monitor the membrane insertion and subsequent glycosylation of recombinant model substrates in cellula and (ii) co-express and purify targeting-factor/substrate complexes of all AtGet3 orthologues that can be used for in vitro analyses. In a reverse genetic approach, I could show that the function of AtGet3c seems to be involved in the assembly and stability of components of the respiratory chain in mitochondria. And, that AtGet3b is involved in de novo photosystem (PS) assembly and repair in thylakoids. Further, I could also show that AtGet3b binds photosynthetic membrane proteins in transmembrane domain (TMD) dependent manner and under oxidative stress it shares features of proteinaceous membrane less organelles (PMLOs). Additionally, the comparison of the wild-type chloroplast proteome to mutant chloroplasts lacking and overexpressing AtGet3b revealed a possible involvement in protein transport, Fe-S cluster biogenesis and membrane remodeling. This study characterizes the yet undescribed organellar Get3 orthologues of Arabidopsis thaliana and paves a way for subsequent scientific interrogations. Further, the methods established for the cytosolic Get3 orthologues can help propel the biochemical in vitro analysis of plant derived GET constituents.
Germanium distribution in Mississippi Valley-Type systems from sulfide deposition to oxidative weathering: A perspective from Fule Pb-Zn(-Ge) deposit, South China
Authors: Wei Chen , Frenzel Max , Ye Lin , Huang Zhilong , Danyushevsky Leonid
Published: January 2024

Germanium (Ge) is a critical raw material for emerging high-tech and green industries, resulting in considerable recent interest in understanding its distribution and geochemical behavior in ore deposits. In this contribution, the distribution of Ge and related trace elements in the Fule Pb-Zn(-Ge) deposit, South China, is investigated to reveal the distribution of Ge in the hydrothermal ores and during sulfide weathering, using multiple microanalytical techniques, including scanning electron microscopy, electron probe microanalysis and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). In the Fule MVT deposit, sphalerite (ZnS) is the most significant Ge-carrier relative to other sulfides, though the five recognized textural types of sphalerite display progressive depletion in Ge from the first sphalerite generation to the late one. In the early stage, sphalerite with fine-grained chalcopyrite inclusions has the highest Ge concentrations, probably accounting for a significant proportion of the total Ge. We interpret that high Ge concentrations in the early sphalerite may be attributable to high Cu activity in the mineralizing fluids. During oxidative weathering, Ge was redistributed from its original host, sphalerite, to the weathering product willemite (Zn2SiO4) rather than smithsonite (ZnCO3), with high levels of Ge (up to 448 μg/g) present in the willemite. The formation of abundant willemite largely prevents the dispersion of Ge during weathering. In principle, willemite-hosted Ge should be fully recoverable, and the Zn-silicate ores may, therefore, be a potential target to meet future demand. This study provides new information on how Ge behaves from sulfide- to weathering-stage in MVT systems, which directly impacts Ge mobility and deportment changes and the development of metal-lurgical strategies for Ge recovery.
Re-examination of vesbine in vanadate-rich sublimate-related associations of Vesuvius (Italy): Mineralogical features and origin
Authors: Pellino Annamaria , Balassone Giuseppina , Abad Isabel , Altomare Angela , Bellatreccia Fabio , Cappelletti Piergiulio , Falcicchio Aurelia , Mondillo Nicola , Herrington Richard , Isè Cristiana , Petti Carmela , Rumsey Mike
Published: January 2024

A set of 23 vesbine-bearing samples from Vesuvius volcano (Italy), preserved in the collection of the Royal Mineralogical Museum of Naples, University Federico II (RMMN), have been investigated to identify the mineral assemblages and their mode of formation. In the late 19th century, fumarole-related yellow patinas coating some historical lavas from Vesuvius were believed by Scacchi to contain a new element, vesbium, similar to vanadium in a mineral he called vesbine. Subsequent studies rejected vesbium and showed that vesbine was a poorly defined mixture of copper vanadates and halides. The vesbine samples studied here consist of yellowish to yellow-green-blue encrustations on Vesuvius lavas and have been analyzed by combined optical microscopy, SEM-EDS, XRPD, FTIR, and TEM-HRTEM-EDS. Results reveal complex mineral associations, including vanadates, halides, carbonates, oxides, silicates, tungstates/molybdates, and sulfates. The vanadates correspond to mottramite, volborthite, and vanadinite; subordinate amounts of descloizite were detected by XRPD and FTIR investigations. Several additional non-essential elements have been detected in the vanadates, including Mn, Zn, and As. The occurrence of wulfenite- and stolzite-rich phases indicates the presence of Mo and W, along with Pb, in the mineralizing fluids. Mn-rich phases, commonly in mixtures with silicates and vanadates, were also observed. These minerals are formed by a combination of different processes, including rock-fluid interactions, gas-water interactions, and alteration/oxidation of primary fumarolic minerals. Temperatures for the depositions of the vanadates-bearing assemblages are interpreted to be in the range of 100 to 400 °C.
Fire and Water: Geometallurgy and Extractive Metallurgy
Authors: Chetty Deshenthree , Nwaila Glen T. , Xakalashe Buhle
Published: January 2024

There is no doubt that mineralogy, texture, and microfabric, as primary characteristics of an ore, affect mineral processing operations. Their direct effects on extractive metallurgical processes and the associated optimization potential, however, are less well documented. Here, we examine the status of geometallurgical approaches in extractive metallurgy by focusing on the effects of primary ore characteristics in hydrometallurgical and pyrometallurgical processes. Two selected case studies illustrate the linkages. Using quantitative data analytics on ores and concentrates, the possibilities for optimized and sustainable metal extraction and waste valorization are discussed.
Zasada godności człowieka w systemie europejskiej konwencji bioetycznej
Authors: Jasudowicz Tadeusz
Published: January 2024

Kategoria godności ludzkiej stanowi centralną i naczelną wartość/zasadę w prawie międzynarodowym praw człowieka. Przyrodzona godność osoby ludzkiej jest źródłem praw człowieka, a wraz z nimi stanowi podstawę wolności, sprawiedliwości na świecie. Europejska Konwencja Bioetyczna jest traktatem praw człowieka objętym powyższym ustaleniem generalnym. Ze swej strony wpisuje godność już w sam swój tytuł, potwierdza jej znaczenie w swojej preambule, w szczególności zaś nakłada na strony w art. 1 obowiązek poszanowania przyrodzonej godności i tożsamości wszystkich istot ludzkich, także w stadium prenatalnym. W całymsystemie Konwencji, wespół z protokołami dodatkowymi do niej, godność stanowi wartość zasadniczą i naczelną, kojarzoną z wartościami tożsamości, integralności, równości i niedyskryminacji. Przedmiotowo kojarzy się z samą wyróżnioną jakością człowieczeństwa, z całym bytem człowieka – od zapoczątkowania życia po jego kres. Wszelkie ciosy przeciwko życiu – czy to u jego początków, czy też jego kresu – stanowią zarazem pogwałcenie godności człowieka, której nie wolno wykorzystywać przeciwko człowiekowi i jego życiu.
Obowiązki państwa pochodzenia marynarza związane z pośrednictwem pracy
Authors: Pyć Dorota
Published: January 2024

W niniejszym artykule przedstawiono kilka wybranych aspektów związanych z wykonywaniem przez państwo pochodzenia  marynarza obowiązków w zakresie naboru i pośrednictwa pracy marynarzy do pracy na statkach morskich, ze szczególnym uwzględnieniem polskiej perspektywy prawnej. Konwencja o pracy na morzu (MLC) jest najważniejszym międzynarodowym instrumentem regulacyjnym dotyczącym warunków życia i pracy marynarzy na statkach morskich. MLC wymaga, aby państwo zapewniło marynarzom dostęp do skutecznego i dobrze zorganizowanego systemu naboru i pośrednictwa pracy. W Polsce obowiązki państwa w zakresie naboru i pośrednictwa pracy dla marynarzy regulowane są przede wszystkim przepisami ustawy o pracy na morzu w 2015 r. Obejmują one takie instrumenty, jak: audyt i certyfikację agencji zatrudnienia w celu zapewnieniaskutecznego nadzoru i kontroli nad tymi podmiotami, zaangażowanymi w pośrednictwo pracy marynarzy do pracy na statkach morskich.
Wybrane zagadnienia prawnopodatkowe w kontekście szkicu wskazań katolickiej nauki społecznej
Authors: Kucharski Adam
Published: January 2024

Przedmiotem opracowania jest ukazanie wybranych aspektów prawa podatkowego, w świetle podstawowych wskazań społecznej nauki Kościoła katolickiego. Obiektem analizy będą wybrane obszary polskiego prawa podatkowego, zarówno w ujęciu praw i obowiązków podatników, jak i prawodawcy. Chodzi zatem o reguły stanowienia, stosowania, jak i przestrzegania prawa. Przywołane zasady rangi konstytucyjnej, będą punktem odniesienia dla umiejscowienia jednostki w obowiązującym systemie państwowym, gdzie porządek prawny jest ukazany głównie jako forma ekspresji społecznej moralności. Ukazanie sygnalizowanego pejzażu prawnego na tle katolickiej nauki społecznej wymaga wyartykułowania jej zasad oraz wyjaśnienia pozycji poszczególnych rozwiązań prawnych w jej kontekście. Prowadzi to do zestawienia ze sobą oczekiwań środowisk prawników oraz społecznych etyków katolickich. To właśnie działanie jest przedmiotem niniejszego opracowania.
Odpowiedzialność cywilnoprawna za działania sztucznej inteligencji – próba analizy
Authors: Sieroń Michał , Rosiak Przemysław Kamil
Published: January 2024

Artykuł stanowi próbę analizy kwestii odpowiedzialności cywilnoprawnej za działania sztucznej inteligencji (AI). Autorzy dokonują analizy tego zagadnienia w świetle istniejących konstrukcji odpowiedzialności na gruncie polskiego prawa cywilnego, w tym odpowiedzialności na zasadzie ryzyka, winy w nadzorze, oraz z uwzględnieniem szczególnego rodzaju odpowiedzialności za produkt niebezpieczny na tle przepisów dyrektywy Rady z 25.07.1985 r. w sprawie zbliżenia przepisów ustawowych, wykonawczych i administracyjnych Państw Członkowskich dotyczących odpowiedzialności za produkty wadliwe (85/374/EWG). Wykorzystującprzykłady zastosowania AI przy wprowadzaniu inteligentnych robotów oraz autonomicznych pojazdów, autorzy zwracają uwagę na brak kompleksowej regulacji zasad odpowiedzialności w razie szkód spowodowanych w związku z korzystaniem z nowoczesnych technologii, wskazują na trudności w skutecznym dochodzeniu roszczeń przez osoby poszkodowane oraz niepewność prawną na gruncie obecnych przepisów. Artykuł przedstawia także inicjatywy na szczeblu europejskim, dotyczące uregulowania kwestii związanych z omawianą tematyką, w tym efekty prac grup eksperckich powołanych przez Komisję Europejską.
Reklama porównawcza w USA
Authors: Sielewicz Wanda
Published: January 2024

Artykuł zatytułowany ,,Reklama porównawcza w USA”, ma na celu omówienie zjawiska reklamy porównawczej w tym kraju.  Dokonałam w nim opisu historii oraz pochodzenia tejże reklamy. A także przedstawiłam, jak zgodnie z prawem można używać reklamy porównawczej. Starałam się dokonać przeglądu regulacji. Bowiem w USA reklama porównawcza jest regulowana przez połączone przepisy federalne, stanowe i lokalne, a także przez własny kodeksy prawne postępowania. Przedstawiam zjawisko tak zwanych ,,Wojen reklamy porównawczej”, które są bardzo ciekawym zagadnieniem i także – moim zdaniem – stanowią kwintesencjęreklamy porównawczej. Opisuję najbardziej spektakularną wojnę, która miała miejsce na rynku amerykańskim.
Zbieg reżimów odpowiedzialności administracyjnej z odpowiedzialnością karną za przestępstwo (wykroczenie) w ruchu lądowym
Authors: Zwierz Marta
Published: January 2024

Celem opracowania jest zwrócenie uwagi na niejednolity i problematyczny z punktu widzenia obywateli schemat oddziaływania konstytucyjnego zakazu ne bis in idem na materię administracyjnoprawną. Jako tezę wyjściową autor przyjmuje stanowisko,zgodnie z którym granice obowiązywania zakazu ne bis in idem w prawie administracyjnym wyznaczają poszczególne sfery ingerencji administracji publicznej. Na przykładzie art. 103 ust. 1 pkt 4 ustawy z 5.01.2011 r. o kierujących pojazdami (Dz. U. z 2021 r. poz. 1212 ze zm.) zwróci uwagę na zależności zachodzące pomiędzy aksjologicznie uwarunkowanym przez wiele wartości  konstytucyjnych zakazem ne bis in idem a klauzulą interesu publicznego. Autor wskaże na zastosowane przez ustawodawcę w powyższej ustawie techniki legislacyjne, które prowadzą do kolizji norm prawa administracyjnego i karnego, a staroście przyznają jednocześnie kompetencje do rozszerzania mocy wiążącej prawomocnych orzeczeń sądów karnych na inne aniżeli wymienione w nich kategorie uprawnień. Na podstawie ilościowej i jakościowej analizy Centralnej Bazy Orzeczeń Sądów Administracyjnych zwróciuwagę na skalę zaistniałego problemu na tle innych kategorii uprawnień i rozbieżność stanowisk obejmowanych do tej pory w niniejszej kwestii przez sądy administracyjne.
comunicação da informação sobre arboviroses e a tradução do conhecimento científico em comunidades tradicionais
Authors: Gerlin Meri Nadia Marques , Simeão Elmira Luzia Melo Soares , Mendonça Ana Valéria Machado
Published: January 2024

Relata-se uma pesquisa realizada no âmbito do Projeto Arbocontrol observando como as bibliotecas, arquivos e museus podem utilizar a informação da área da saúde em projetos com comunidades tradicionais e periféricas. Situadas à margem dos benefícios concedidos às regiões metropolitanas, essas comunidades sofrem com a falta de acessibilidade aos programas vacinais, à água tratada, saneamento básico, entre outros. Reúnem-se esforços para analisar a viabilidade da tradução do conhecimento da informação em saúde sobre arboviroses em regiões quilombolas, indígenas, ciganas, pomeranas e em outros territórios de povos tradicionais para o trabalho nas unidades de informação. Para o alcance desse objetivo, procede-se ao estudo exploratório e, quanto aos procedimentos, ao levantamento bibliográfico e documental no âmbito da Ciência da Informação e Saúde Coletiva. As pesquisas realizadas pelo Projeto Arbocontrol da Região Sudeste mostram produções científicas e culturais da Rede Brasil de Gestão da Informação e Tradução do Conhecimento. Para comunicar a informação direcionada ao controle das arboviroses dengue, zika, Chikungunya e febre amarela, produzida entre os anos de 2020 a 2022, identifica-se a relevância da disseminação de sínteses científicas por meio da narrativa de histórias provenientes da literatura oral brasileira e, especialmente, direcionadas ao público infantojuvenil. Destaca-se, portanto, a necessidade de os profissionais da informação e saúde atuarem colaborativamente em unidades de informação e saúde com grupos das comunidades tradicionais, dialogando sobre a origem da ancestralidade disseminada pela oralidade e sobre a estratégia da comunicação da informação da área da saúde realizada por meio da tradução das pesquisas sobre prevenção das arboviroses.
Evaluation of Roxithromycin as a Treatment Option for Small Abdominal
Aortic Aneurysms: An Integrated Study of Meta-analysis
and Network Pharmacology
Authors: He Zhen , Chen Yu , Wang Hongjie , Dai Lei , Zeng Hesong
Published: January 2024

Background::

Abdominal aortic aneurysm (AAA) is a segmental, progressive,
and fatal vascular disorder, and the current strategy for small AAAs is close observation
alone.The purpose of this study is to summarize the available evidence to assess the effects
of antibiotics on small abdominal aortic aneurysms (AAA).

background:

Abdominal aortic aneurysm (AAA) is a segmental, progressive, and fatal vascular disorder, and the current strategy for small AAAs is close observation alone.

Methods::

We searched PubMed, EMBASE, Web of Science, and Scopus from inception
to September 29, 2023, and included randomized controlled trials (RCTs) that evaluated
the effects of antibiotics on small AAAs in humans. We first performed a meta-analysis
to assess the effects of antibiotics on small AAAs. Afterward, network pharmacology
analysis was applied to investigate the optimal drug generated from the meta-analysis
results. We searched Pharmmapper and GeneCards to obtain the common potential targets
of the selected drug and AAA-related targets. The protein-protein interaction network
and functional enrichment analysis were performed by the STRING database, Cytoscape
3.7.2 software, and R, respectively. Docking studies were carried out for validation.

Results::

We incorporated data from six RCTs involving a total of 997 patients. The results
of this meta-analysis revealed that roxithromycin exhibited a modest yet statistically
significant protective effect in terms of slowing down the AAA expansion rate. Furthermore,
our subsequent bioinformatics analysis pinpointed MMP-2, MMP-9, ALB,
MMP-3, and CCL-5 as potential therapeutic targets that could be explored for the treatment
of AAA using roxithromycin.

Conclusion::

In conclusion, the study indicates roxithromycin is a promising drug for
treating small AAAs and supports its underlying clinical use in small AAAs.
Perillyl Alcohol Promotes Relaxation in Human Umbilical Artery
Authors: de Sena Bastos Carla Mikevely , Pereira-de-Morais Luis , de Alencar Silva Andressa , de Menezes Dantas Débora , Batista Paulo Ricardo , Gomes Maria Franciele Lima , de Araújo Delmondes Gyllyandeson , de Menezes Irwin Rose  Alencar , da Silva Renata Evaristo Rodrigues , Barbosa Roseli
Published: January 2024

Background:

Perillyl alcohol (POH) is a monoterpenoid found in plant essential
oils and has been shown to relax murine vessels, but its effect on human vessels remains
poorly studied.

Objective:

The study aimed to characterize the effect of POH on human umbilical arteries
(HUA).

Methods:

Rings of HUA were obtained from uncomplicated patients and suspended in
an organ bath for isometric recording. The vasorelaxant effect of POH in HUA was evaluated
on basal tone and electromechanical or pharmacomechanical contractions, and possible
mechanisms of action were also investigated.

Results:

POH (1-1000 μM) altered the basal tone of HUA and completely relaxed HUA
rings precontracted with KCl (60 mM) or 5-HT (10 μM), obtaining greater potency in
the pharmacomechanical pathway (EC50 110.1 μM), suggesting a complex interference
in the mobilization of extra- and intracellular Ca2+. POH (1000 μM) inhibited contractions
induced by BaCl2 (0.1-30 mM) in a similar way to nifedipine (10 μM), indicating a
possible blockade of L-type VOCC. In the presence of potassium channel blockers, tetraethylammonium
(1 mM), 4-aminopyridine (1 mM), or glibenclamide (10 μM), an increase
in the EC50 value of the POH was observed, suggesting a modulation of the activity
of BKCa, KV, and KATP channels.

Conclusion:

The data from this study suggest that POH modulates Ca2+ and K+ ion channels
to induce a relaxant response in HUA.
Developments of Fms-like Tyrosine Kinase 3 Inhibitors as Anticancer
Agents for AML Treatment
Authors: Ma Chenchen , Cui Siyuan , Xu Ruirong
Published: January 2024

Background:

FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated
gene in acute myeloid leukemia. As a receptor tyrosine kinase (RTK), FLT3 plays a role
in the proliferation and differentiation of hematopoietic stem cells. As the most frequent
molecular alteration in AML, FLT3 has drawn the attention of many researchers, and a
lot of small molecule inhibitors targeting FLT3 have been intensively investigated as potential
drugs for AML therapy.

Methods:

In this paper, PubMed and SciFinder® were used as a tool; the publications
about “FLT3 inhibitor” and “Acute myeloid leukemia” were surveyed from 2014 to the
present with an exclusion of those published as patents.

Results:

In this study, the structural characterization and biological activities of representative
FLT3 inhibitors were summarized. The major challenges and future directions for
further research are discussed.

Conclusion:

Recently, numerous FLT3 inhibitors have been discovered and employed
in FLT3-mutated AML treatment. In order to overcome the drug resistance caused by
FLT3 mutations, screening multitargets FLT3 inhibitors has become the main research
direction. In addition, the emergence of irreversible FLT3 inhibitors also provides new
ideas for discovering new FLT3 inhibitors.
Based on Serum Pharmacochemistry and Virtual Screening Technique
Analysis Used to Explore the Potential Active Ingredients and Possible Anti-
Coronary Heart Disease Mechanisms of Salvia miltiorrhiza Bunge
Authors: Shi Yuhe , Li Qing , Zhu Jue , Hou Chao wen , Li Xiao ling , Liu Xiang dan , Tong Qiao zhen
Published: January 2024

Aims and Objective::

This study aimed to identify the bioactive compounds and explore
the multi-target mechanisms of Salvia miltiorrhiza Bunge (SMB) against coronary heart
disease (CHD) using an integrated serum pharmacochemistry and network pharmacology approach.

Materials and Methods::

The chemical constituents of SMB were characterized by UPLC-MS.
The absorbed ingredients and metabolites after oral SMB administration were identified in rat
serum. Therapeutic targets of SMB against CHD were predicted by intersecting the targets of
absorbed compounds from databases and CHD-associated genes. Protein-protein interaction network,
pathway analysis, molecular docking, and molecular dynamic simulation were performed.

Results::

A total of 61 SMB-derived compounds were identified in rat serum. Network analysis
revealed 111 candidate targets highly related to CHD pathways. Further topological analysis
identified 10 hub targets and 20 key active compounds, constructing an informative compoundtarget-
pathway network. PTGS2 and TNF were predicted as primary targets of SMB against
CHD based on molecular dynamic simulation.

Conclusion::

This integrated approach identified bioactive compounds and multi-target mechanisms
of SMB against CHD. The results provide scientific evidence supporting SMB's clinical
efficacy and reveal potential anti-CHD targets.
Reactions and Biological Activities of Hydrazonoyl Halides
Authors: Alarbash Munirah F. , Al-Faiyz Yasair S. , Wiggins Jeffrey S. , Sayed Abdelwahed R.
Published: January 2024

This review covers the literature information on the chemistry of hydrazonoyl halides with
different substrates to give heterocyclic compounds. From the foregoing survey, it seems this provides
a useful and convenient strategy for the synthesis of numerous heterocyclic derivatives. The subject of
such reactions is still ongoing and undoubtedly will provide new fused functionalized compounds of
both industrial and biological interest. A literature survey revealed that a great deal of interest has been
focused on the synthesis of functionalized heterocyclic compounds due to their wide range of biological
activities, such as contact dermatitis, anthelmintic, antiviral, antimicrobial, herbicidal, and anti-cancer.
On the other hand, hydrazonoyl halides are interesting synthons for valuable bioactive heterocyclic
compounds. The reaction of hydrazonoyl halides with various types of substrates gave a huge number
of different heterocyclic systems. In this review, we collected all reactions of hydrazonoyl halides with
different moieties and classified them as aryl diazo of monoheterocycles, aryldiazo of 5,5-bis-heterocycles,
aryldiazo of 5,6-bis-heterocycles, aryldiazo of 6,6-bis-heterocycles, aryldiazo of 5,5,6-tri-heterocycles,
aryldiazo of 5,6,6-tri-heterocycles, aryldiazo of 6,6,6-tri-heterocycles, hetero annulation of bisheterocycles,
hetero annulation of tri-heterocycles, hetero-annulation of tetra-heterocycles, synthesis of
spiro-heterocycles, heterocyclic ring transformations, and 1,3-dipolar cycloaddition reactions catalyzed
by transition metals using hydrazonoyl halides as substrates.Most reaction types have been successfully
applied and used in the production of biologically active compounds.

:

The aim of the present survey is to consider in the reader the opportunity interactions and biological
activities of hydrazonoyl halides. The information of several artificial paths and varied physics-chemical
factors of such heterocycles made a special consideration of chemists in different fields to yield
a combinatorial library and carry out thorough efforts in the search for hydrazonoyl halides.
Structure-based Virtual Screening from Natural Products as Inhibitors of
SARS-CoV-2 Spike Protein and ACE2 Receptor Binding and their
Biological Evaluation In vitro
Authors: Delgado-Maldonado Timoteo , Gonzalez-Morales Luis Donaldo , Juarez-Saldivar Alfredo , Lara-Ramírez Edgar E. , Rojas-Verde Guadalupe , Moreno-Rodriguez Adriana , Bandyopadhyay Debasish , Rivera Gildardo
Published: January 2024

Background:

In the last years, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) caused more than 760 million infections and 6.9 million deaths. Currently, remains
a public health problem with limited pharmacological treatments. Among the virus drug
targets, the SARS-CoV-2 spike protein attracts the development of new anti-SARS-CoV-2 agents.

Objective:

The aim of this work was to identify new compounds derived from natural products
(BIOFACQUIM and Selleckchem databases) as potential inhibitors of the spike receptor binding
domain (RBD)-ACE2 binding complex.

Methods:

Molecular docking, molecular dynamics simulations, and ADME-Tox analysis were
performed to screen and select the potential inhibitors. ELISA-based enzyme assay was done to
confirm our predictive model.

Results:

Twenty compounds were identified as potential binders of RBD of the spike protein. In
vitro assay showed compound B-8 caused 48% inhibition at 50 μM, and their binding pattern exhibited
interactions via hydrogen bonds with the key amino acid residues present on the RBD.

Conclusion:

Compound B-8 can be used as a scaffold to develop new and more efficient antiviral
drugs.
Hepatitis E Virus in Individuals Undergoing Heparin Therapy: An
Observational Serological and Molecular Study
Authors: Mesquita João R. , Santos-Silva Sérgio , Ferreira Nanci , Rivero-Juarez Antonio , Gonçalves Guilherme , São José Nascimento Maria
Published: January 2024

Introduction::

Heparin is derived from swine and has been suggested as a possible
source of HEV. To study the potential risk of HEV infection associated with heparin treatment,
two groups of individuals were compared. Sera from heparinized (N=93) and non-heparinized
individuals (N=111) were tested for markers of acute HEV infection and anti-HEV IgG seroprevalence.

Method::

An acute HEV case was defined by the presence of anti-HEV IgM and/or HEV RNA.
From the 93 heparinized individuals, one was positive for IgM and IgG anti-HEV and two were
positive for HEV RNA (for both ORF3 and ORF2), and there were a total of two (2.2%) cases of
current or recent HEV infection. From the 111 non-heparinized individuals, three were positive
for IgM anti-HEV, one was positive for both IgM and IgG anti-HEV, and none was positive for
HEV RNA, and there were a total of three (2.7%) cases of current or recent HEV infection. The
difference between HEV cases in the heparinized individuals and the non-heparinized individuals
was not statistically significant (2.2% vs. 2.7%; p = 0.799).

Results::

Concerning IgG anti-HEV, it was detected in 32 individuals from the heparinized group
and in 18 from the non-heparinized control group. A statistically significant difference was observed
in the presence of anti-HEV IgG in heparinized individuals and controls (p = 0.003).

Conclusion::

This study has not found any association between heparin treatment and acute HEV
infection, but has shown the use of therapeutic heparin as a risk factor for IgG anti-HEV seropositivity.
Tumor Necrosis Alpha (TNF-α) Antagonists Used in Chronic Inflammatory
Rheumatic Diseases: Risks and their Minimization Measures
Authors: Lakhmiri Rim , Cherrah Yahia , Serragui Samira
Published: January 2024

Tumor necrosis factor alpha (TNF- α) inhibitors are widely employed for the management of chronic inflammatory rheumatism. However, their usage carries significant risks, including site and infusion reactions, serious infections, malignancy, heart failure autoimmune and
demyelinating disorders. These risks are comprehensively outlined in risk management plans
(RMPs) associated with these molecules. RMP provides information on the safety profile of a
medicinal product as well as the measures that will be taken to minimize risks; these are known
as risk minimization measures. These measures are divided into routine measures related to elements, such as the summary of product characteristics, labeling, pack size, package leaflet, or
legal supply status of the product, while additional measures may include educational programs,
including tools for healthcare providers and patients, controlled access or pregnancy prevention
programs, among others. Additional measures can consist of one or more interventions that need
to be implemented in a sustainable way in a defined target group, while respecting the timing
and frequency of any intervention and procedures to reach the target population. An evaluation
of the effectiveness of these measures is required to determine whether or not an intervention
has been effective. This comprehensive review offers an in-depth exploration of the current
treatment, uses, and associated risks of TNF-α inhibitors. Additionally, it provides a detailed account of risk minimization measures and risk management practices while shedding light on
their real-world implementation and effectiveness.
Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced
Hepatotoxicity in Mice via Repressing Oxidative Stress, Inflammatory Cytokines, and
Cell Apoptosis
Authors: ALRashdi Barakat M. , Hussein Mohamed M. , Mohammed Rawan M. , Abdelhamed Nada W. , Asaad Maran E. , Alruwaili Mubarak , Alrashidi Saad M. , Habotta Ola A. , Abdel Moneim Ahmed E. , Ramadan Shimaa S.
Published: January 2024

Background:

Doxorubicin (DOX) is an antitumor anthracycline used to treat a variety of malignancies;
however, its clinical use is associated with noticeable hepatotoxicity. Therefore, the current study was designed
to delineate if biosynthesized SeNPs with turmeric extract (Tur-SeNPs) could alleviate DOX-induced
hepatic adverse effects.

Methods:

Mice were orally post-treated with Tur extract, Tur-SeNPs, or N-acetyl cysteine after the intraperitoneal
injection of DOX.

Results:

Our findings have unveiled a remarkable liver attenuating effect in DOX-injected mice post-treated with
Tur-SeNPs. High serum levels of ALT, AST, ALP, and total bilirubin induced by DOX were significantly decreased
by Tur-SeNPs therapy. Furthermore, Tur-SeNPs counteracted DOX-caused hepatic oxidative stress,
indicated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and
mRNA expression levels of Nrf-2. Noteworthily, decreased hepatic IL-1β, TNF-α, and NF-κB p65 levels in addition
to downregulated iNOS gene expression in Tur-SeNPs-treated mice have indicated their potent antiinflammatory
impact. Post-treatment with Tur-SeNPs also mitigated the hepatic apoptosis evoked by DOX injection.
A liver histological examination confirmed the biochemical and molecular findings.

Conclusions::

In brief, the outcomes have demonstrated Tur loaded with nanoselenium to successfully mitigate
the liver damage induced by DOX via blocking oxidative stress, and inflammatory and apoptotic signaling.
Mirror Symmetry Coils for Foreign Object Detection and Location with Wireless Power Transmission
Authors: Xu Yuhui , Xu Jin
Published: January 2024

Background:

Wireless power transmission technology effectively avoids safety issues
caused by accidental contact, wire aging, and friction. However, due to the presence of foreign
objects, other severe accidents such as fire hazard can occur, and the charging system can be interfered
with and even damaged by the foreign objects.

background:

As a new charging technology, the wireless power transmission (WPT) technology has shown some favorable application prospects on safety, reliability, and convenience.

Method:

Therefore, this paper proposes (MSD) mirror symmetry detection coils to detect and locate
foreign objects. First, we conduct theoretical analysis and derive formulas to validate our
proposed method. Next, we employ ANSYS Maxwell to simulate the (WPT) wireless power
transmission system, considering various sizes and materials of foreign objects and comparing
them to a system without foreign objects. Result: Furthermore, we conducted experiments using
mirror symmetrical detection coils to detect and locate foreign objects, providing additional verification
for our proposed method.

Conclusion:

The simulation and experimental results show that the proposed method of mirror
symmetry detection coils can effectively identify and locate the foreign objects.
Technological tools in English language teaching activities to deaf students
Authors: Arroyo-Cedeño Carmen Gemaris , Zambrano-Mera Dayana Yirley , Mendoza-Ponce Henry Xavier
Published: January 2024

A study of the impact that technological tools have on the activities of teaching the English language to deaf students is shown. The difficulties that this segment of the student population has in relation to the resources or materials available for the teaching-learning process of the English language, in addition to the difficulties they have in the development of these language skills. In this sense, the research adopted a mixed qualitative-quantitative approach. The objective was to diagnose the technological tools used in learning the English language in the EGB student of the Liceo "El Oasis", and analyze the results obtained through the application of data collection instruments designed based on the declared variables. The result was that the causes that make learning the English language difficult for students with hearing disabilities is demotivation, according to 50%, indicating that they cannot establish fluid communication. The main conclusion revolves around that the EducaPlay Educational Software can contribute to the development of the English language skills of students with hearing disabilities; but now, teachers do not know about this type of application. It must be considered that the case studied does not learn at the same pace as his peers.
WEB 3.0 e design da informação aproximações e oportunidades
Authors: Pironi Guilherme Oliveira
Published: January 2024

This research discusses how the approximation between Web 3.0 (or Semantic Web) and Information Design is configured through a qualitative approach via an exploratory-descriptive nature and seeks to understand the origins, current levels of each of the subjects and subsequently establishes possible intersections between them. It concluded that the tools and technologies of Web 3.0 are capable of searching, analyzing, organizing and offering content very efficiently, but in order to have a better conversion of these into quality information for those who access it, the practice of Information Design is recommended on such contents, promoting the transformation of web data into intelligible information that can contribute in areas such as interface design, education and business.
Tecnologia e Organização da Informação VII TOI 2021 - Transformação Digital Contribuições da Ciência da Informação
Authors: palleta Francisco Carlos , Silva Armando Malheiro da , Ohmaye Helio
Published: January 2024

The TOI -7th International Conference on Technology and Information Organization is an initiative of the Observatory of the Labor Market in Information and Documentation research group (OMTID -CNPq) of the School of Communications and Arts of the University of Sao Paulo. In academic and scientific collaboration with CITCEM -Center for Transdisciplinary Research Culture, Space and Memory, based at the Faculty of Arts of the University of Porto, and LTi -Laboratory of Intellectual Technologies of the Federal University of Paraiba. The TOI -7th International Conference on Information Technology and Organization is focused on bringing together researchers, students, and professionals in the field of Information Science: Librarianship, Archival Science and Museology, and related, with the goal of promoting reflection and dialogue about relevant topics for the information society and sharing knowledge about the most innovative practices in this area. The program of this event covers the following fields of knowledge: Information Management, Technology and Information Systems, Digital Libraries, Information and Knowledge Organization, Collection Conservation and Preservation, Digital Curation; Information Ethics, Digital Humanities, Information Retrieval on the Data Web, Data Science, Internet of Things, Artificial Intelligence, Computational Culture, Information Professional Job Market and Data Engineering. The event is completely free and broadcast online through YouTube channel, areas such as interface design, education and business.
Impactos da ciência aberta na autoria e autoridade científica em pesquisas colaborativas sobre cannabis medicinal
Authors: Gama Ivanilma de Oliveira , Cianconi Regina de Barros , Gomez Maria Nélida González de
Published: January 2024

The mainobjective of the study is to investigate the epistemic construction of collective authorship and scientific authority in scientific productions of collaborative research on medicinal cannabis. The methodology involved bibliographic and documentary research to present, through the lens of open science, the impacts on sharing scientific data from collaborative networks. It discusses the changes in copyright with the introduction of communicationtechnologies, analyzes legal guidelines regarding scientific data, and proposes the concept of collective authorship. Multiple case studies were employed along with interviews with researchers studying the medicinal effects of the cannabisplant to examine the main discussions and transformations regarding the granting of authority in scientific production and the paths that copyright laws have been tracing. It is concluded that there is potential in the scientific field for the proposals of the open science movement, primarily due to the advantages of collaboration invarious instances, but copyright laws need advancements to support disputes over symbolic capital.
Representação da Informação em Mangás uma proposta de diretrizes
Authors: Santana Fernanda Lacerda , Pavarina Etefania Cristina , Coneglian Caio Saraiva
Published: January 2024

Considering the growing prominence of manga as informational resources in information units, this research aims to propose guidelines for information representation in manga, with the goal of enhancing the effectiveness of representation and retrieval of these resources in the collections of information units. Methodologically, this study adopts a qualitative, exploratory, and documentary approach, based on bibliographic research procedures. The results provide guidelines for the analysis of manga, which encompass image description elements intended to represent aspects related to the content, form, and context of manga. The proposed model is exemplified through its application to two widely recognized manga in popular culture. It is concluded thatthere is a need to further research in the field of Information Science regarding the representation of informational resources that combine two or more languages, as is the case with manga, where verbal and visual languages coexist intricately. However, the presented model proves to be effective in representing fundamental aspects for information retrieval, thereby contributing to improving the documentary treatment of these resources in information units.
Cultura digital e hibridização nos espaços de leitura na contemporaneidade
Authors: Rodrigues Olira Saraiva
Published: January 2024

This article presents the intentionto explore the metamorphoses that permeate the realm of contemporary culture in relation to reading spaces. Through this research, the aim is to discuss digital culture, examining the impact of the incorporation of technological devices that resonate within sociocultural contexts. To achieve this goal, the research discussesinterconnection and hybridization, which propose a broader understanding of ongoing transformations. The methodological approach adopted in this study is qualitative and exploratory innature, relying on bibliographic research for its procedures. From this ground, a broader comprehension emerges, as contemporary digital epistemologies foster technological integration into society, engendering renewed perspectives on literacy. This technological incursion intervenes in established modes of reading and creates a conducive scenario for formulating new outlooks, triggering the reconfiguration of processes, methods, functions, and the scope of spaces designated for reading.
Relações epistemológicas entre a gramática gerativa transformacional de Noam Chomsky e a organização do conhecimento
Authors: Veronez Júnior Wilson Roberto
Published: January 2024

Noam Chomsky is considered one of the greatest thinkers of the 20th century, and his contribution to Language is evident. The article analyses a possible dialogue between Transformational Generative Grammar, Chomsky's generativism and innatism, and the Knowledge Organization. By establishing epistemological and disciplinary relations with Knowledge Organization, Transformational Generative Grammar highlights the creative aspect of those who are building a given System, which in turn requires the incorporation of documentary languages, thesauriand ontologies, among other elements, for example. When designing these systems, in addition to knowledge of the social contextin which the subject is culturally inserted, the designer must have solid knowledge of the main relationships between that community and its main informationalneeds. For future analyses, this research will discuss in depth the relationship between Chomsky's Transformational Generative Grammar and Knowledge Organization for the development of documentary languages.
Marketing e Comunicação em Bibliotecas Universitárias da teoria aos estudos aplicados (2015-2021) no contexto informacional digital
Authors: Gomes Liliana Isabel Esteves , Marcial Viviana Fernández
Published: January 2024

This article aims to identify scientific production related to Marketing and Communication in university libraries and to analyse the focus of applied studies. The qualitative methodology adopted comprises an exploratory approach through the literature review. From the results obtained we highlight: the gradual dissemination and promotion of the university library services through tools provided by Web 2.0; the growing use of social networks as means of communication; the contradiction between Marketing principles, which emphasise the importance of the customer at the centre of decisions on promotional strategies, and library practice, which places service managers and information professionals at the centre. All in all, the focus of applied studies is on the perspective of information professionals or institutions. A change in the Marketing and Communication strategies adopted by university libraries is considered urgent and it is essential to identify the real needs and information profile of the client, as well as to periodically evaluate the results of the Marketing and Communication strategies implemented.
O efeito de magneto da língua materna sobre o PLE a morfologia e a fonologia
Authors: Rodrigues Alexandra Soares
Published: January 2024

Portuguese as a Foreign Language (PFL)learners, A1 level,systemically present phonological productions and morphological constructions that result from the magnet effectof their native languageon the foreign language. In this work we will explore these systemic productions, which we will classify as surplus andindeficit. We propose that surplus productions correspond to the inclusion of features existing in the native languagein PFLproductions, from whosesystem they are absent, and that productions in deficit are related to features existing in the PFLand ignored by learners due to the fact that these features are not found in theirnative language.Based on the analysis of productions by students from the Polytechnic Institute of Bragança on mobility programmes, whose mother tongues are Chinese, Japanese, Polish, Spanish, Turkish, Lithuanian, Tetum and Hungarian,we will reflect on strategies that a foreign languageteacher can use in the teaching-learning process so that the productions in focus can be solved