bluuebunny/crossref_metadata_2025 huggingface dataset:
Applications of Protein Epitope Mimetics in Vaccine Design.
Authors: Pfeiffer Bernhard , Moreno Rafael , Moehle Kerstin , Zurbriggen Rinaldo , Glück Reinhard , Pluschke Gerd , Robinson John A.
Published: May 2022

An approach to synthetic vaccine design is illustrated, focusing on the immunodominant (NPNA)n repeat region of the circumsporozoite (CS) protein of the malaria parasite Plasmodium falciparum. Modelling suggests that the NPNAN motif may adopt a helical β-turn, which is tandemly repeated in the CS protein to generate a novel supersecondary structure. Cyclic peptidomimetics of this NPNAN motif were synthesized and shown by NMR to adopt helical turns in aqueous solution. When incorporated into Immunopotentiating Reconstituted Influenza Virosomes (IRIVs), humoral immune responses were generated in mice that crossreact with native CS protein on sporozoites. IRIVs are a human-compatible delivery system that appear generally suitable for inducing antibody responses against conformational epitopes using constrained peptidomimetics. This approach may offer great potential for the design of molecularly defined synthetic vaccines, including those targeted against multiple antigens and development stages of P. falciparum, or against other infectious agents.
Chemical Biology of Mammalian DNA Repair
Authors: Schärer Orlando D.
Published: May 2022

Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways. Base excision repair involves the sequential action of at least four enzymes and is initiated by DNA glycosylases. A lot of progress
has recently been made toward elucidating of the molecular mechanisms by which DNA glycosylases recognize damaged bases in DNA and catalyze the cleavage of the N-glycosidic bond between the base and the sugar-phosphate backbone. This advance was brought about by a combination of chemical and
biochemical approaches to generate stable complexes of DNA glycosylases bound to their substrates or substrate analogs and X-ray crystallography to determine the structure of these complexes at atomic resolution. Nucleotide excision repair requires the concerted action of 15–18 polypeptides
to excise an oligonucleotide of about 30 bases in length containing the damaged residue. The structures of several DNA intermediates in the process are known and the reaction has been recently reconstituted with purified proteins. We know less about the details of how the proteins involved
recognize and excise damaged DNA and how specific protein-protein interactions govern the overall process. It is expected that our understanding of nucleotide excision repair will be significantly advanced through the development of novel chemical and cell biological approaches in the near
future.
From the Biopolymer PHB to Biological Investigations of Unnatural β- and γ-Peptides
Authors: Seebach Dieter , Albert Matthias , Arvidsson Per I. , Rueping Magnus , Schreiber Jürg V.
Published: May 2022

An overview is given of the past and present activities of our group in the field of chemical biology. Thus, the polymer of 3-hydroxybutanoic acid (PHS), which is omnipresent in living organisms, triggered our search for a better analytical method for detecting PHB and our syntheses of oligomers of 3-hydroxyalkanoic acids (OHSs). Also, the regulation of DNA replication by poly(β-malic acid) (PMA) in certain eukaryotes inspired synthetic work on the corresponding cyclic and open-chain oligomers. With these oligomers we not only tested the mechanisms of depolymerases, but were able to study the properties and activities of well-characterized compounds (also with isotope and fluorescence labeling). The role of PHS as component of ion transport systems through phospholipid bilayers was unambiguously established, and models for the channel structure were proposed. Replacement of amino acids by 3-hydroxybutanoic acid residues in peptides and replacement of the chain-bound oxygens in OHB by NH paved our way into the world of β- and γ-peptides, the synthesis and physiological and pharmacological properties of which are being investigated. β-Peptides are stable to peptidases, have a long lifetime in mammalian serum and are rather resistant to environmental microbial degradation. The peptides consisting of homologated (β) or doubly homologated (γ) amino acids form stable secondary structures in solution (helices, turns, sheets) which can be used as scaffolds for peptide mimics, such as a β-tetrapeptide with affinity to a somatostatin receptor or a β-nonapeptide that inhibits intestinal lipid-transport protein (SR-BI) in Caco-2 cells. Certain β-peptides have antibacterial, antiproliferative and haemolytic properties. The lessons from studies of β- and γ-peptides teach us about the central role of natural α-peptidic proteins.
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Oral bioavailable and Blood Brain Barrier Penetrant PROTAC Degrader of Leucine Rich Repeat Kinase 2 (LRRK2)
Authors: Liu Xingui , Kalogeropulou Alexia , Domingos Sofia , Makukhin Nikolai , Nirujogi Raja , Singh Francois , Shpiro Natalia , Saalfrank Anton , Sammler Esther , Ganley Ian , Moreira Rui , Alessi Dario , Ciulli Alessio
Published: May 2022

Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s Disease. LRRK2 targeting strategies have primarily focused on Type 1 kinase inhibitors, which however have limitations as the inhibited pro-tein can interfere with natural mechanisms which could lead to undesirable side effects. Herein, we report the devel-opment of LRRK2 Proteolysis Targeting Chimeras (PROTACs), culminating in the discovery of degrader XL01126, as an alternative LRRK2 targeting strategy. Initial designs and screens of PROTACs based on ligands for E3 ligases VHL, CRBN and cIAP identified the best degraders containing thioether-conjugated VHL ligand VH101. A second round of medicinal chemistry exploration led to qualifying XL01126 as a fast and potent degrader of LRRK2 in multiple cell lines, with DC50 values within 15-72 nM, Dmax values range from 82-90%, and degradation half-lives span from 0.6h to2.4h. XL01126 exhibits high cell permeability and forms a positively cooperative ternary complex with VHL and LRRK2 (α=5.7), which compensates for a substantial loss of binary binding affinities to VHL and LRRK2, underscoring its strong degradation performance in cells. Remarkably, XL01126 is orally bioavailable (F=15%) and can penetrate the blood brain barrier after either oral or parenteral dosing in mice. Taken together, these experiments qualify XL01126 as a suitable degrader probe to study non-catalytic and scaffolding functions of LRRK2 in vitro and in vivo and offer an attractive starting point for future drug development.
An Open-Source Molecular Builder and Free Energy Preparation Workflow
Authors: Bieniek Mateusz , Cree Ben , Pirie Rachael , Horton Joshua , Tatum Natalie , Cole Daniel
Published: May 2022

Automated free energy calculations for the prediction of binding free energies of congeneric series of ligands to a protein target are growing in popularity, but building reliable initial binding poses for the ligands is challenging. Here, we introduce the open-source FEgrow workflow for building user-defined congeneric series of ligands in protein binding pockets for input to free energy calculations. For a given ligand core and receptor structure, FEgrow enumerates and optimises the bioactive conformations of the grown functional group(s), making use of hybrid machine learning / molecular mechanics potential energy functions where possible. Low energy structures are optionally scored using the gnina convolutional neural network scoring function, and output for more rigorous protein–ligand binding free energy predictions. We illustrate use of the workflow by building and scoring binding poses for ten congeneric series of ligands bound to targets from a standard, high quality dataset of protein–ligand complexes. Furthermore, we build a set of 13 inhibitors of the SARS-CoV-2 main protease from the literature, and use free energy calculations to retrospectively compute their relative binding free energies. FEgrow is freely available at https://github.com/cole- group/FEgrow, along with a tutorial.
Generation and Aerobic Oxidative Catalysis of a Cu(II) Superoxo Complex Supported by a Redox-Active Ligand
Authors: Czaikowski Maia , McNeece Andrew , Boyn Jan-Niklas , Jesse Kate , Anferov Sophie , Filatov Alexander , Mazziotti David , Anderson John
Published: May 2022

Cu systems feature prominently in aerobic oxidative catalysis in both biology and synthetic chemistry. Metal ligand cooperativity is a common theme in both areas as exemplified by galactose oxidase and by aminoxyl radicals in alcohol oxidations. This has motivated investigations into the aerobic chemistry of Cu and specifically the isolation and study of Cu superoxo species that are invoked as key catalytic intermediates. While several examples of complexes that model biologically relevant Cu(II) superoxo intermediates have been reported, they are not typically compe-tent aerobic catalysts. Here, we report a new Cu complex of the redox-active ligand tBu,TolDHP (2,5-bis((2-t-butylhydrazono)(p-tolyl)methyl)-pyrrole) that activates O2 to generate a catalytically active Cu(II)-superoxo complex via ligand-based electron transfer. Characterization using UV-visible spectroscopy, Raman isotope labeling studies, and Cu extended X-ray absorption fine structure (EXAFS) analysis confirms the as-signment of an end-on η1 superoxo complex. This Cu-O2 complex engages in a range of aerobic catalytic oxidations with substrates including alcohols and aldehydes. These results demonstrate that bio-inspired Cu systems can not only model important bioinorganic intermediates but can also mediate and provide mechanistic insight on aerobic oxidative transformations.
Effect of background luminance of visual stimulus on elicited steady-state visual evoked potentials
Authors: Zhang Shangen , Chen Xiaogang
Published: May 2022

Steady-state visual evoked potential (SSVEP)-based brain– computer interfaces (BCIs) have been widely studied. Considerable progress has been made in the aspects of stimulus coding, electroencephalogram processing, and recognition algorithms to enhance system performance. The properties of SSVEP have been demonstrated to be highly sensitive to stimulus luminance. However, thus far, there have been very few reports on the impact of background luminance on the system performance of SSVEP-based BCIs. This study investigated the impact of stimulus background luminance on SSVEPs. Specifically, this study compared two types of background luminance, i.e., (1) black luminance [red, green, blue (rgb): (0, 0, 0)] and (2) gray luminance [rgb: (128, 128, 128)], and determined their effect on the classification performance of SSVEPs at the stimulus frequencies of 9, 11, 13, and 15 Hz. The offline results from nine healthy subjects showed that compared with the gray background luminance, the black background luminance induced larger SSVEP amplitude and larger signal-to-noise ratio, resulting in a better classification accuracy. These results suggest that the background luminance of visual stimulus has a considerable effect on the SSVEP and therefore has a potential to improve the BCI performance.
Co-immunolocalization of Disc1 and Gas7 protein in adult mice brain
Authors: Kumar Udaya
Published: May 2022

Objective:

The aim of the present study was to check the potential interaction of two neurodevelopmental proteins, Disc1 and Gas7, in the adult mice brain.

Methods:

Twenty-four male Swiss albino mice were used for the study. The mice were 12 weeks old in the beginning of the experiment. Immunohistochemistry and co-immunofluorescence were performed on the coronal sections of mice brain and immunoblotting and co-immunoprecipitation were done on the whole brain lysate.

Results:

Data from immunohistochemistry and co-immunofluorescence indicate the occurrence and co-localization of Disc1 and Gas7 proteins in soma and projections of the brain cells. Immunostaining was observed in cerebral cortex, hypothalamus, midbrain, pons, medulla oblongata and CA3 of hippocampus of the brain. The data from Immunoblotting and co-immunoprecipitation validates the presence and interaction of Disc1 and Gas7 protein in whole brain lysate.

Conclusion:

Data indicates the potential interaction of Disc1 and Gas7 protein in adult brain. The study highlights the need for further research on Disc1–Gas7 protein interaction in brain development and neuro-disorders.
ОЦІНКА ФІЗИЧНОЇ ПІДГОТОВЛЕНОСТІ СТУДЕНТІВ (СЕКЦІЇ ВАЖКОЇ АТЛЕТИКИ ТА СКАНДИНАВСЬКОЇ ХОДЬБИ)
Authors: Глядя С. О. , Юшко О. В. , Борейко Н. Ю. , Азаренкова Л. Л.
Published: May 2022

У статті проаналізовано наявні види контролю та обґрунтовано зміст тестів і нормативів для оцінювання фізичної підготовленості студентів під час проведення навчальних занять з важкої атлетики та скандинавської ходьби, оцінено фізичну підготовленість студентів (секцій важкої атлетики та скандинавської ходьби). Матеріал і методи. У дослідженні взяли участь 24 студенти (чоловіки, основна медична група) зі спортивної спеціалізації «важка атлетика» та 24 студенти (чоловіки, основна медична група) секції скандинавської ходьби. Експеримент тривав протягом навчального року, заняття проводились за розкладом два рази на тиждень. Методи дослідження: аналіз і узагальнення даних науково-методичної та спеціальної літератури; педагогічне спостереження; тестування студентів. Результати. Застосовано комплексний аналіз з видів підготовленості студентів. Розглянуто вплив і взаємодію вправ з комплексів тестів із загальної фізичної та зі спеціальної фізичної підготовленості на студентів-важкоатлетів та студентів секції скандинавської ходьби. Виявлено рівень розвитку показників загальної та спеціальної фізичної підготовленості студентів НТУ «ХПІ», які займаються у секціях важкої атлетики та скандинавської ходьби. За даними дослідження студенти секції важкої атлетики мають високі показники за результатами тестування сили, а саме в підтягуванні на перекладині, стрибку у довжину з місця та нахилі тулуба вперед з положення сидячи, низькі показники в тестуванні витривалості. У студентів секції скандинавської ходьби, навпаки, найкращі показники у тестуванні рівномірного бігу 3000 м та гнучкості. Запропоновано засоби оцінювання спеціальної фізичної підготовленості для секції важкої атлетики: стрибок угору з місця, потрійний стрибок у довжину, згинання і розгинання рук в упорі на підлозі з оплеском, піднімання ніг угору з вису на перекладині, та секції скандинавської ходьби: ходьба з палками на 100 метрів з виконанням елементів техніки скандинавської ходьби. Висновки. Визначено рівень фізичної підготовленості студентів, які займаються важкою атлетикою та скандинавською ходьбою. Відмінний рівень мають 25% студентів, а 16,7% студентів – добрий рівень, 50% студентів – задовільний рівень і 8,3% студентів – незадовільний рівень фізичної підготовленості. Оптимальне поєднання засобів загальної і спеціальної фізичної підготовки підвищує рівень працездатності студентів, сприяє ефективному виконанню тренувальних навантажень та більш швидкої спортивної результативності.
МЕТОДИ ДІАГНОСТИКИ СТАНУ ЗДОРОВ’Я І ФУНКЦІОНАЛЬНОГО СТАНУ У СПОРТИВНИХ ІГРАХ
Authors: Квасниця О. М. , Коваленко Ю. О. , Тищенко В. О.
Published: May 2022

Здійснено теоретичний аналіз проблеми оцінки впливу фізичного навантаження на організм спортсмена. Показано, що поряд із впровадженням різних інструментальних методів дослідження діяльності апарату кровообігу у спортсменів не втратили свого значення найпростіші методи дослідження. Найбільш поширеним методом, що використовує тренер у практичній діяльності, є визначення частоти пульсу. У разі оцінки даних пульсометрії тренер повинен мати уявлення про фазовий характер змін, що відбуваються у серцево-судинній системі під впливом фізичного навантаження. У ході теоретичного аналізу проблеми встановлено, що у роботі з максимальною інтенсивністю в перші 10–15 с частота пульсу збільшується до 130–150 ударів на хвилину, а потім спостерігається повільне зростання до 180–200 уд/хв. У висококваліфікованих спортсменів слідом за фазою стабілізації іноді можна спостерігати фазу компенсації, за якої у результаті вдосконалення адаптації організму до фізичного навантаження відбувається зниження низки фізіологічних показників. Теоретично доведено, що з ростом рівня тренованості відбувається зниження реактивності серцево-судинної системи на однакове навантаження. При цьому зменшуються почастішання пульсу і підвищення артеріального тиску, прискорюється настання фази стійкого стану, коротшає період відновлення. У разі наростання стомлення у спортсмена реакція на стандартне навантаження супроводжується більш значним почастішанням пульсу, порушенням його ритму, високим систолічним тиском або, навпаки, недостатнім його зростанням. Підтверджено в результаті дослідження, що у разі контролю за функціональним станом спортсмена з використанням тільки часу виконання контрольного тесту та ЧСС необхідно пам’ятати: якщо час виконання тесту зменшується і зменшується сума трьох показників ЧСС, то функціональний стан спортсмена відмінний, а тренувальний процес побудованій правильно; якщо час тесту збільшується, а сума трьох показників ЧСС зменшується, то функціональний стан спортсмена можна оцінити як задовільний; якщо час тесту збільшується і сума трьох показників ЧСС збільшується, то функціональний стан спортсмена незадовільний.
Reversing Biodiversity Decline in Aotearoa New Zealand
Authors: Clarkson Bruce
Published: May 2022

Reflections on the history of and prognosis for reversing biodiversity in Aotearoa New Zealand are provided from the perspective of a 40-year involvement in terrestrial ecology and its interface with central and local government policy development and implementation. The emerging favourable policy framework, continuing growth of iwi-and community-led conservation, and a shift to regional-scale restoration give cause for optimism. But reversal of biodiversity decline over still greater areas is required, alongside an in-perpetuity commitment to management that enhances indigenous biodiversity.
Towards Implementing Board Gender Diversity in Sri Lanka
Authors:   , Angammana Menaka
Published: May 2022

Corporate governance is an increasingly topical theme. The voluminous literature on corporate governance is specifically affirmed by International Financial Institutions (IFIs) in reasoning out that good corporate governance practices can develop the economy by attracting investors and securing foreign direct investment. Accordingly, these IFIs have included corporate governance reform as a condition for funding to developing countries. Sri Lanka is an illustrative example of a developing country forced by IFIs to improve its corporate governance practices as a step towards advancing economic growth. The Sri Lankan legislators have been incorporating corporate governance rules of the United Kingdom (UK) to reform corporate governance practices within the country. Among these, board gender diversity is acknowledged as a legal strategy that is capable of providing economic and equality benefits. The economic benefits are based on the contribution women directors can make towards advancing board effectiveness. The equality benefits underpinning this strategy depict the manner in which gender equality could be promoted by board gender diversity rules. While the UK corporate governance rules have incorporated this strategy, the Sri Lankan legislators have not considered this approach. This study builds on this gap and explores through a socio-legal lens the feasibility of implementing board gender diversity rules in Sri Lanka. It demonstrates that board gender diversity rules could be a valuable tool for corporate governance development and to promote gender equality in society.
Barishaler Jogen Mandal: Construal of the Undisputed Dalit Leader of Undivided Bengal through a Twenty-first Century Bengali Novel
Authors: Roy Suhasini
Published: May 2022

Barishaler Jogen Mandal is a Bengali novel by Debes Ray, published in 2010 from Kolkata, India. The book revisits the socio-political arena of Bengal during the final decade of colonial rule by construing Namasudra politician Jogendranath Mandal (1904 –1968) as the central figure. This article studies the novel as a literary appendage to anti-caste thought—as an attempt to reclaim the Dalit history of the nation and re-establish the significance of J.N. Mandal in the history of anti-caste politics. My reading of the novel reflects Bakhtinian perspective of inseparability between form and content. The novel traces evolution of J.N. Mandal’s political disposition through novelisation of history, while addressing the nation building processes in late colonial South Asia and developing conceptual understanding of Dalithood in terms of imposed powerlessness as well as wisdom and culture acquired in the intimate connection they share with the habitat through everyday struggle for survival. I argue that the author develops his locus throughout the novel by adopting J.N. Mandal’s own standpoint. With adherence to a definite sudra perspective, the text navigates history, challenging many of the discipline’s standardised interpretations. It engages with the discourse of power by strategically situating itself at the peripheral locus of the Dalit life-world, and develops the narrative of power as it would appear from that fringe. By doing so, it effectually calls for a conceptual inversion of power, re-centring it in terms of Dalit history.
UPAYA MENINGKATKAN KETERAMPILAN MENULIS PANTUN DENGAN MODEL PEMBELAJARAN KONTEKSTUAL PADA PESERTA DIDIK KELAS V SD
Authors: Muspirati Muspirati
Published: May 2022

The purpose of this research is to improve the skill of writing rhymes. The subjects in this study were educators and fifth grade students of SD Negeri 01 Pasangkayu. The teaching methods and methods tend to be conventional and traditional, thus making the students' ability to write poems lacking. Contextual learning model is one of the efforts used to improve the ability to write rhymes. This classroom action research (CAR) was carried out in two cycles. Starting with the identification of problems that exist in the classroom by taking pre-cycle actions. The stage of each cycle begins with planning in the form of compiling learning steps through the application of contextual models. The results showed that the application of the contextual model had improved the students' skills in writing rhymes. The skills of educators in this study have been declared complete. The skills of students in learning have increased from cycle one and cycle two, in cycle one educators achieved a good category with a success percentage of 77% and in cycle II increased by 96% with a very good category. The activities of students have reached the indicators of success and are declared complete. The activity of students in learning has increased, in cycle one it reaches a good category. In the aspect of student attention, it was 85%, in the second cycle it increased by 95%. In the aspect of the learning situation of students in the first cycle of m80%, and in the second cycle of 85%. The children's poetry writing skills have reached the indicators of success and were declared complete. Classical learning completeness in the pre-cycle is only 35%, and in the first cycle it increases by 80%, and in the second cycle the increase reaches 100%. This research is proven to be able to improve the quality of learning which includes the skills of educators, student activities and the results of rhyme writing skills.
Build of Machine Learning Proxy Model for Prediction of Wax Deposition Rate in Two Phase Flow Water-Oil
Authors: Septiano Jalest , Yasutra Amega , Rahmawati Silvya Dewi
Published: May 2022

Wax deposit is one of the major fl ow assurance experienced in the process of oil production and transportation from sub- surface to surface. Large amounts of data are required to perform modeling using existing thermodynamic models such as carbon number data from HGTC. In this paper, a machine learning algorithm using unifi ed model approach from Huang (2008). Two types of input are implemented in order to simulate infl uence of feature selection used in training and testing machine learning which are input A consists of water volume fraction (fw), shear stress (τw), effective viscosity (μe), wax concentration gradient (dC/dT), and temperature gradient (dT/dR) and input B consists of water volume fraction (fw), shear stress (τw), effective viscosity (μe), wax concentration gradient (dC/dT), temperature gradient (dT/dR), shear stripping variable (SV) dan diffusion variable (DV). The random forest with Ntree = 500 known to be the best machine learning method compared to others. Based on accuracy parameter it achieves error parameter R-squared (R2) for training, testing and total data for input A and B are 0.999, 0.992, 0.9975 and 0.999, 0.993, 0.9977, respectively.
Review of intervertebral hernia disease treatment methodologies:
Key emphasis on the oxygen-ozone therapy as a method with
multifactorial influence
Authors: Baranova Iryna , Postovitenko Olga , Postovitenko Kateryna , Iliuk Iryna , Osypenko Iryna
Published: May 2022

Introduction

Low back pain is one of the most common causes of short-term, and sometimes long-term, disability in the population younger than 45 years old. Approximately 60% to 80% of the population in developed countries experience back pain in various locations (neck, mid and lower back) at least once in their lifetime. Guidelines regarding back pain treatment are undergoing constant modifications and improvements. The relevance of dorsalgia as a significant medical problem and its management is shown by the increased number of recently published papers, which has tripled in the past several years (from 22% to 65%).

Aim

To analyze the most critical risk factors of the degenerative intervertebral disk disease, and to review the effectiveness of invasive and noninvasive methods of treatment of the lower back pain syndrome.

Material and methods

Recently published papers focusing on invasive and noninvasive treatments of low back pain syndrome.

Results and discussion

Surgical intervention as a single method of back pain treatment is indicated in a small number of cases. The risk of repeated surgeries for intravertebral disk herniation should be considered before any surgical intervention. A wide variety of treatment options allows to choose the most effective approach based on individual needs.

Conclusions

Conservative, noninvasive approach has shown to be an effective alternative for lower back pain and radiculopathy treatment. It has been determined that ozone therapy is an appropriate, relevant, and affordable treatment method for patients with vertebral degenerative changes and intravertebral disk diseases.
Inmunodermatología: horizonte y oportunidades
Authors: Vélez-Posada Lina , Londoño-García Ángela
Published: May 2022

La inmunología es una ciencia joven dentro de las diferentes disciplinas de la medicina moderna. Nace finalizando el siglo XIX, con estudios basados en microbiología y el descubrimiento de la fagocitosis por Elias Metchnikoff. De allí surgen los primeros hallazgos de la inmunidad innata y se complementa con el descubrimiento de los anticuerpos neutralizantes por parte de Emil Behring y Paul Ehrlich. Luego de este descubrimiento, se empieza a hablar de inmunidad adquirida.
Esta visión dicotómica dio lugar a cierta confusión y controversia y se necesitó algún tiempo hasta que se transformara en una perspectiva de complementariedad entre ambas vías, que consideraba a la inmunidad innata y adquirida como un par interactivo, un concepto entrelazado, parcialmente superpuesto y mutuamente beneficioso.
Cromomicosis, una enfermedad tropical olvidada: revisión de tema a propósito de un caso clínico
Authors: Botello-Mojica Heliana Marcela , Den-Medina Lucía Vanden en , Jaramillo- Ayerbe Felipe , Marulanda-Galvis Mayra Alejandra
Published: May 2022

Introducción: Introducción: La cromomicosis es una infección fúngica crónica, progresiva y granulomatosa con distintas manifestaciones en la piel y el tejido celular subcutáneo. Causada por múltiples especies de hongos dematiáceos. Se manifiesta como placas eritematoescamosas y verrucosas de lento crecimiento que presentan puntos negros en su superficie. El diagnóstico se realiza a partir de la clínica y la demostración del hongo.Metodología: Reporte de caso clínico y revisión narrativa de la literatura tipo revisiones y revisiones sistemáticas de lo publicado entre el periodo 2000 - 2021, en las bases de datos PubMed y Scopus empleado las palabras claves Chromomycosis, Chromoblastomycosis , Chromoblastomycoses, Dermatitis Verrucosa, Chromomycoses, Dematiaceous fungi y Subcutaneous mycoses.Resultados: Se presenta el caso de un hombre de 54 años con diagnóstico de cromomicosis de larga data proveniente de zona rural del departamento del Meta, Colombia y se discute la epidemiología, etiología, patogénesis, manifestaciones clínicas, complicaciones, diagnóstico, los principios terapéuticos, el seguimiento y pronóstico de esta patología.Conclusiones: La cromomicosis es una infección fúngica generalmente encontrada en áreas tropicales y subtropicales, sin embargo, publicaciones de los últimos años han cambiado la perspectiva epidemiológica considerándose actualmente una infección cosmopolita, con casos reportados en los cinco continentes. Los conceptos clínicos se han mantenido en el tiempo; se han propuesto nuevos métodos diagnósticos los cuales no están ampliamente disponibles y continúa siendo un verdadero reto terapéutico pues las tasas de curaciones no son altasy con frecuencia es refractaria a los distintos manejos.
Dermatitis shiitake: reacción al consumo de setas
Authors: García Margarita María , Muvdi-Arenas Sandra
Published: May 2022

La dermatitis shiitake es una reacción cutánea causada por la ingestión de setas shiitake crudas o poco cocinadas. Su fisiopatología no se comprende completamente, pero se sugiere que se debe al Lentinan, un polisacárido termolábil que se encuentra en la pared celular del hongo. La erupción dermatológica se manifiesta con pápulas eritematosas lineales, en un patrón flagelado, asociadas a prurito intenso y generalmente involucra el tronco y las extremidades. Es una afección autolimitada, aunque los síntomas se pueden tratar con medicamentos antihistamínicos y corticoides tópicos. Se presenta el caso de un paciente masculino caucásico de 28 años, sin antecedentes patológicos, quien consultó por aparición de lesiones cutáneas 72 horas después de la ingesta de setas shiitake. Hay un aumento en la ingestión de este hongo en los países occidentales, por lo que los profesionales de la salud y dermatólogos deben conocer las lesiones cutáneas características asociadas a su consumo.
Bogor Water Adequacy Status for 2009-2019
Authors: Tarigan Nita , Perdinan  , Bambang Dwi Dasanto
Published: May 2022

Water adequacy becomes one of the global concerns as the trend of population growth continues to arise. The condition of water adequacy can be worse in some regions since it also relates to rainfall, which is greatly influenced by global climate change. Here we explore water adequacy at local scale especially in Bogor, Indonesia based on sectoral water demands. The study aims to analysis water adequacy for 2009-2019 based on a climatic water balance. Water supply-demand analysis was performed using water usage index (WUI) in which high WUI corresponds to high critical water balance. Our results showed there was a deceased trend for water supply in Bogor approximately 0.6% per year, whereas an increased trend was observed for water demand (1.7% per year). The main contributor for the increased demand was from domestic water demand by 48%. Generally, water adequacy in Bogor for the period analysis (2009 -2019) is still adequate, but a proper management of water resource will ensure water adequacy in the long run in response to population explosion and climate change.
Front Matter
Authors: Seminar Annisa Utami
Published: May 2022

Front Matter - JSKPM Vol. 06 No. 02 April 2022
Pemanfaatan Limbah Bonggol Jagung Menjadi Pakan Ternak (Silase) di Desa Sendangmulyo, Kecamatan Bulu, Kabupaten Rembang
Authors: Widjaja Hermanu , Mujahidin Brilianza Azharul , Marfuah Marfuah , Tiara Tiara , Hidayah Annisa Nur , Alfiani Yulisa , Nailussaada Diah
Published: May 2022

Sendangmulyo Village is one of the villages in Bulu District, Rembang Regency, which is located on the border of Blora Regency. One of the agricultural commodities that are widely cultivated in Sendangmulyo Village is corn. However, the use of this corn commodity is generally still limited to the seeds, while the cob is discarded and instead pollutes the environment. Seeing this problem, the IPB Rembang KKN-T group held a webinar as well as the practice of making silage made from corn cobs. The purpose of this program is to provide an understanding to the people of Sendangmulyo Village regarding the utilization of corncob waste into silage. The webinar was held online through the zoom meeting platform for the general public, then continued with the practice of making silage together for the people of Sendangmulyo Village. The materials used in making silage are corn cobs and elephant grass that have been chopped, bran, molasses, and water. Quality silage can be seen from physical characteristics such as color, texture, aroma, and the presence of mushrooms. Based on the results of observations, the silage made has a light brown color, is not runny and has a slightly sour smell but there is still a little fungus so that the silage results can be classified as poor. The implementation of the webinar and the direct practice of making silage from corn cobs received a positive response from the webinar participants and the people of Sendangmulyo Village. The disadvantage of this program is that in the practice of making silage the number of participants is limited due to the PPKM period so that the delivery of information has not been widely conveyed.
Pengelolaan Hutan Rakyat Berbasis Ameliorasi dan Agroforestri di Sekitar Taman Nasional Gunung Halimun Salak Desa Pulosari Jawa Barat
Authors: Arsyianti Laily Dwi , Permatasari Jesika , Mulyani Sri , Mahmudin Iqbal
Published: May 2022

Pulosari village is adjacent to forest land. The intensification of agricultural land is expanding as population growth increases the need for food. The conversion of forest land into agricultural land is continuously realized to cause many problems such as decreased soil fertility, erosion, extinction of flora and fauna, floods, droughts and even changes in the global environment. This problem is getting worse over time as the area of forest converted into agricultural land increases. Based on this, optimal land management activities are needed to obtain maximum results in meeting the needs of the increasing population. One way that can be done is through amelioration and agroforestry activities. This Community Service Program aims to assist the target community in developing their land in the form of community forest or community plantation forest so that their use can be intensified in order to provide additional income through amelioration and agroforestry activities. The specific target achieved is to improve the skills of forest land management by farmers by applying amelioration and agroforestry systems to unproductive land. The specific objective of this KKNT program is expected to be achieved through community empowerment of the Sumber Rejeki Farmer Group with the target of activities being the socialization of amelioration and agroforestry work programs as well as training on amelioration and agroforestry techniques to farmers. Pulosari village has a very large agricultural land, around 2,500 ha, with initially focus on horticultural crops. This program encourages farmers to implement amelioration and agroforestry for sustainable agriculture in their land.
Teknologi Pompa Air Listrik untuk Menanggulangi Krisis Air di Desa Ciaruteun Ilir Binaan Komunitas Pendidik Nusa Bogor
Authors: Damari Arfan
Published: May 2022

Ciaruteun Ilir is a village in the Bogor Regency area that becomes a problem in the form of a lack of well water during the dry season. The community overcomes this problem by taking water from the spring by walking through agricultural fields. Constraints of distance, time and, energy make people need more effort to get water. The Komunitas Pendidik Nusa together with the Yayasan Shaf Indonesia has changed the way of taking conventional water by incorporating electric water pump technology. The results of this service allow the community to enjoy clean water directly in their respective homes. A total of 15 families or the equivalent of 60 people felt the effects of this activity. As many as forty percentage residents have difficulty accessing water with electric pumps installed due to income constraints.
Review of Offset and Noise Reduction Techniques for CMOS
Authors: Dos Reis Carlos Alberto
Published: May 2022

Input referred offset voltage, 1/f noise and thermal noise are amplifier properties that directly restrict the ability of discerning signals beyond a certain limit. The ever increasing spectrum of applications of integrated circuits and trends in the semiconductor market have pushed engineers to design circuits with successively lower voltage, less power consumption, higher dynamic range, accurate gain and wider bandwidth, preferably altogether. Amplifiers input errors are key properties, which have to be minimized, however with the least negative impact upon the other equally important properties. This paper reviews some the most relevant techniques applied to reducing input errors of CMOS amplifiers aiming at to provide a condensed set of information that can help designers at the starting point of a new design of a precision analog circuit. The focus in all cases that were selected to be studied in this review work was the reduction of offset and noise regardless of any commitment of the used technique with other characteristics of the amplifier and its impacts on figures of merit like NEF and PEF.
Are CMOS Operational Transconductance Amplifiers Old Fashioned? A Systematic Review
Authors: Aparecido da Silva Braga Rodrigo , Moreira e Silva Paulo Marcio , Bicudo Karolak Dean
Published: May 2022

Operational Transconductance Amplifiers (OTAs) are essential building blocks in analog circuits. Since the early years of integrated circuit science, OTAs have been used in industry and researched in academia. Over the years, a number of techniques and approaches to OTA design have been observed in the literature. With this systematic review, we aim to provide a overview of top  journal papers published from 2017 to 2021 containing OTA design. In our investigation we initially found 128 manuscripts and 24 primary studies of OTA design. A set of 10 different techniques have been found. Furthermore, we also evaluate used technology, inversion level and characterization process. With this study we contribute to highlight recent OTA design innovations.
Surface versus Performance Trade-offs: A Review of Layout Techniques
Authors: Maris Ferreira Pietro , Avignon-Meseldzija Emilie , Bénabès Philippe , Trélin Francis
Published: May 2022

Selecting the relevant layout techniques is a key point to obtain a high-performance integrated circuit. Most of the common layout techniques, beside allowing the improvement of performance, also leads to an area overhead. Moreover, this area overhead is generally not accurately evaluated. It is proposed in this review to analyze and to evaluate the surface versus performance trade-off in three types of circuits : digital, low-frequency and radiofrequency analog circuits. Each circuit is post-layout simulated using BiCMOS SiGe 55 nm technology from STMicroelectronics. The first analysis evaluates the surface, power consumption and speed trade-off in a digital circuit implementing a 16-bit gray counter, when selecting different combinations of gates from the B55 digital library. The second analysis focuses on the implementation of an accurate capacitor ratio for switched capacitor circuits and quantifies the surface versus accuracy performance. The third analysis evaluate the performance trade-off for six different layout techniques applied on a negative resistor required for a VCO.
Having the First-Year as Overseas Students: Intercultural Communication as Identity Negotiation of Indonesian Ph.D. Muslim Women Students in the United States
Authors: Ali Mukti , Arifin Win Listyaningrum , Muttaqin Zaenal
Published: May 2022

This study examined the first-year intercultural communication experiences of Indonesian Ph.D. Muslim women students in the United States as their identity negotiation. The following questions were addressed using Ting Toomey’s intercultural communication theory: What problems do Indonesian Ph.D. Muslim women students face in their new environment in the United States? How do they use intercultural communication as an adaptive strategy? And, to what extent can this intercultural communication skill affect their academic achievement as international students? Using an ethnographic approach, data were obtained through online observations and interviews via WhatsApp and Skype video calls with 11 Indonesian Ph.D. Muslim women students regarding their first-year experiences in the United States. According to the findings of this study, their ability in intercultural communication in their first year becomes the primary capital for their lives during their stay to complete their study. Their experience has turned into knowledge, motivation, and skills that turn out to be beneficial in facing challenges.
Інтеграція бортового обладнання повітряних суден в об`єднану систему розподілу тактичної інформації TADIL J/LINK 16
Authors: Бекіров А. Е. , Сидоренко Є. І. , Чекмарьов В. А. , Смажелюк О. М.
Published: May 2022

У статті розглядається актуальне питання підвищення ефективності дій авіації при функціонуванні в єдиній системі обміну тактичною інформацією. Проводиться аналіз побудови та принципів функціонування тактичного цифрового каналу обміну інформацією збройних сил США та країн НАТО. Розглядається побудова архітектури мережі та порядок об’єднання функціональних мережевих груп. Будується класифікація абонентів мережі. Аналізується бортове обладнання повітряних суден з позиції джерел інформації при функціонуванні в цифровому каналі передачі даних. Формулюються варіанти інтеграції бортового обладнання в обміні інформаційними повідомленнями при наявності багатофункціональної системи розподілу тактичної інформації.
Optimization of Analysis of Circadian Rest-Activity Rhythm Using Cosinor Analysis in Mice
Authors: Lee Jung Hyun , Moon Eunsoo , Park Jeonghyun , Oh Chi Eun , Hong Yoo Rha , Yoon Min
Published: May 2022

Objective Data processing in analysis of circadian rhythm was performed in various ways. However, there was a lack of evidence for the optimal analysis of circadian rest-activity rhythm. Therefore, we aimed to perform mathematical simulations of data processing to investigate proper evidence for the optimal analysis of circadian rest-activity rhythm.Methods Locomotor activities of 20 ICR male mice were measured by infrared motion detectors. The data of locomotor activities was processed using data summation, data average, and data moving average methods for cosinor analysis. Circadian indices were estimated according to time block, respectively. Also, statistical F and p-values were calculated by zero-amplitude test.Results The data moving average result showed well-fitted cosine curves independent of data processing time. Meanwhile, the amplitude, MESOR, and acrophase were properly estimated within 800 seconds in data summation and data average methods.Conclusion These findings suggest that data moving average would be an optimal method for data processing in a cosinor analysis and data average within 800-second data processing time might be adaptable. The results of this study can be helpful to analyze circadian restactivity rhythms and integrate the results of the studies using different data processing methods.
A Single Baseline Amyloid Positron Emission Tomography Could Be Sufficient for Predicting Alzheimer’s Disease Conversion in Mild Cognitive Impairment
Authors: Choo IL Han , Chong Ari , Chung Ji Yeon , Ha Jung-Min , Choi Yu Yong , Kim Hoowon
Published: May 2022

Objective Baseline amyloid burden in mild cognitive impairment (MCI) has been linked to conversion to Alzheimer’s disease (AD), but the comparison of baseline and longitudinal changes in amyloid burden for predicting AD remains unresolved. The objectives of this study aimed to compare the prognostic ability of baseline and longitudinal changes in amyloid burden in MCI patients.Methods Seventy-five individuals with MCI were recruited and examined annually by clinical interviews for a mean follow-up of 24 months (range, 11.6–42.0). [18F]Florbetaben positron emission tomography (PET) scans were performed. T1-weighted 3D volumes were acquired for co-registration, and to define regions of interest. We examined whether baseline and longitudinal amyloid burden changes can improve AD conversion by Cox proportional hazard model analysis and receiver operating characteristic (ROC) curve analysis.Results Cox proportional hazards model analysis showed that baseline amyloid burden was significantly associated with increased risk of conversion to AD (hazard ratio [HR]=10.0; 95% confidence interval [CI], 1.15–85.39; p=0.04), but longitudinal amyloid burden changes was not (HR=0.2; 95% CI, 0.02–1.18; p=0.07). When predicting AD, longitudinal amyloid burden changes had better ROC accuracy of 65.2% (95% CI, 48.4–82.0) than baseline amyloid burden of 59.6% (95% CI, 40.3–79.0), without statistical significance in pairwise comparison.Conclusion A single baseline amyloid PET could be sufficient in the prediction of AD conversion in MCI.
Изотропные дисперсионно-твердеющие сплавы на основе соединений самария с кобальтом с повышенной магнитной жесткостью
Authors: Борута В. С. , Винтайкин Б. Е. , Литвинов О. С.
Published: May 2022

Исследована зависимость магнитных параметров изотропных сплавов на основе системы Sm - Co от содержания различных химических элементов и выбран оптимальный состав. Определены магнитные характеристики 11 опытных сплавов: остаточная индукция, коэрцитивная сила по намагниченности и индукции, критическое поле, характеризующее прямоугольность петли размагничивания, максимальное энергетическое произведение (BH)max и температурный коэффициент индукции. Разработана методика изготовления изотропных спеченных кольцевых магнитов выбранного состава. Особое внимание уделено повышению температурной стабильности и улучшению прочностных характеристик исследуемых сплавов. Предложен оптимальный состав магнита.
Влияние цементации на структуру и коррозионную стойкость низкоуглеродистой стали С22
Authors: Бенлахреджхе Ф. З. , Ноуиджер Э. , Яхиа Л. , Ноуиджер А.
Published: May 2022

Исследовано влияние цементации на коррозионную стойкость углеродистой стали C22 в среде, имитирующей морскую воду с использованием методов потенциодинамической поляризации и импедансной спектроскопии. Определены фазовый состав и структура поверхностных слоев стали после науглероживания методами рентгеновской дифракции и рамановской спектроскопии. Установлено повышение коррозионной стойкости стали С22 после цементации.