bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Efficient Three‐Component Coupling Catalyzed by Mesoporous Copper—Aluminum Based Nanocomposites.
Authors: Dulle Jana , Thirunavukkarasu K. , Mittelmeijer‐Hazeleger Marjo C. , Andreeva Daria V. , Shiju N. Raveendran , Rothenberg Gadi
Published: August 2013

Solid Cu—Al mesoporous sponges are found to be robust, inexpensive and excellent catalysts for the synthesis of propargylamines from aldehydes, cyclic secondary amines and acetylenes.
ChemInform Abstract: Regiodivergent Reductive Coupling of 2‐Substituted Dienes to Formaldehyde Employing Ruthenium or Nickel Catalyst: Hydrohydroxymethylation via Transfer Hydrogenation.
Authors: Koepfer Alexander , Sam Brannon , Breit Bernhard , Krische Michael J.
Published: August 2013

The title reaction provides an alternative to diene hydroformylation due to its regioselectivity.
ChemInform Abstract: Novel Synthesis of Symmetrical 3,3′‐Allyl Dithioethers as Photoplastic Monomer Precursors by Equal Molar Rate Addition of Reactants and Solvent Controlled Oligomerization.
Authors: Moorhoff Cornelis M. , Cook Wayne D. , Braybrook Carl
Published: August 2013

An alternative method is described for the synthesis of title compounds which can be used as monomers in photoplastic polymers.
ChemInform Abstract: Rhodium‐Catalyzed Olefin Isomerization/Allyl Claisen Rearrangement/Intramolecular Hydroacylation Cascade.
Authors: Okamoto Ryuichi , Tanaka Ken
Published: August 2013

The cationic Rh(I)/dppf complex catalyzes the olefin isomerization/allyl Claisen rearrangement/intramolecular hydroacylation cascade of di(allyl) ethers to produce a variety of cyclopentanones.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Organocatalytic Domino Michael/Aldol Reaction of Acyclic 3‐Halogeno‐1,2‐diones to α,β‐Unsaturated Aldehydes.
Authors: Lefranc Alice , Guenee Laure , Alexakis Alexandre
Published: August 2013

This transformation tolerates a large variety of electronically different substituents on both reactive partners.
ChemInform Abstract: Visible‐Light Photocatalytic Radical Alkenylation of α‐Carbonyl Alkyl Bromides and Benzyl Bromides.
Authors: Liu Qiang , Yi Hong , Liu Jie , Yang Yuhong , Zhang Xu , Zeng Ziqi , Lei Aiwen
Published: August 2013

The process is optimized with conditions A) or B) in the presence of either a Ru or an Ir polypyridyl complex.
ChemInform Abstract: One‐Pot, Two‐Step, Microwave‐Assisted Palladium‐Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates.
Authors: Wannberg Johan , Wallinder Charlotta , Uenluesoy Meltem , Skoeld Christian , Larhed Mats
Published: August 2013

The title convenient procedure improved the synthesis of a potent HCV NS3 protease inhibitor by preparing the key aryl fluoride intermediate (XII).
ChemInform Abstract: Selective Ruthenium‐Catalyzed Transfer Hydrogenations of Nitriles to Amines with 2‐Butanol.
Authors: Werkmeister Svenja , Bornschein Christoph , Junge Kathrin , Beller Matthias
Published: August 2013

The bulkiness of 2‐butanol, which is used as hydrogen‐transfer reagent, suppresses the unwanted subsequent reductive amination process.
ChemInform Abstract: Intermolecular Aminotrifluoromethylation of Alkenes by Visible‐Light‐Driven Photoredox Catalysis.
Authors: Yasu Yusuke , Koike Takashi , Akita Munetaka
Published: August 2013

The authors present a highly efficient and regioselective difunctionalization method of C=C double bonds, also applicable to steroid and amino acid scaffolds at “late stage”.
ChemInform Abstract: Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis of Chiral β‐Arylamines by Asymmetric Hydrogenation.
Authors: Liu Guodu , Liu Xiangqian , Cai Zhihua , Jiao Guangjun , Xu Guangqing , Tang Wenjun
Published: August 2013

The newly developed bisphosphorus ligand shows high efficiency in the title reaction and several enamides are hydrogenated with excellent enantioselectivities.
ChemInform Abstract: Facile Cu(I)‐Catalyzed Oxidative Coupling of Anilines to Azo Compounds and Hydrazines with Diaziridinone under Mild Conditions.
Authors: Zhu Yingguang , Shi Yian
Published: August 2013

Primary and secondary anilines can be efficiently oxidized to azo compounds and hydrazines using CuBr and diaziridinone, DTA.
ChemInform Abstract: Enantiocatalytic Activity of Substituted 5‐Benzyl‐2‐(pyridine‐2‐yl)imidazolidine‐4‐one Ligands.
Authors: Drabina Pavel , Karel Sergej , Panov Illia , Sedlak Milos
Published: August 2013

The copper(II) complexes of newly synthesized chiral ligands (I) are studied as enantioselective catalysts for the Henry reaction.
ChemInform Abstract: Copper‐Catalyzed Regioselective Reaction of Internal Alkynes and Diaryliodonium Salts.
Authors: Xu Ze‐Feng , Cai Chen‐Xin , Liu Jin‐Tao
Published: August 2013

A new approach to α‐aryl ketones by the copper‐catalyzed highly regioselective reaction of internal alkynes with diaryliodonium triflates is studied and mechanistic implications resulting from different substrate structures are discussed.
ChemInform Abstract: Palladium‐Catalyzed Formal Hydroacylation of Allenes Employing Acid Chlorides and Hydrosilanes.
Authors: Fujihara Tetsuaki , Tatsumi Kenta , Terao Jun , Tsuji Yasushi
Published: August 2013

The reaction proceeds with excellent regio‐ and stereoselectivities without any directing groups in the acyl chlorides.
ChemInform Abstract: VO(acac)2: An Efficient Catalyst for the Oxidation of Aldehydes to the Corresponding Acids in the Presence of Aqueous H2O2.
Authors: Talukdar Dhrubajyoti , Sharma Kiran , Bharadwaj Saitanya K. , Thakur Ashim Jyoti
Published: August 2013

The reaction provides a variety of carboxylic acids in an efficient manner in MeCN under either conditions A) or B), where similar yields are obtained.
ChemInform Abstract: A Facile Green Synthesis and Anticancer Activity of Bis‐arylhydrazononitriles, Triazolo[5,1‐c][1,2,4]triazine, and 1,3,4‐Thiadiazolines.
Authors: Gomha Sobhi M. , Khalil Khaled D. , El‐Zanaty Ali M. , Riyadh Sayed M.
Published: August 2013

Pyrrole derivative (I) is used as starting material for a series of title compounds of type (III), (V), (VII), and (XI).
ChemInform Abstract: Controlled Synthesis of 1‐Vinylnaphthalenes versus (E)‐α‐(1,3‐Enyn‐4‐yl)‐α,β‐unsaturated Esters from Morita—Baylis—Hillman Bromides: A Sequential Alkynylation and Competitive 6π‐Electrocyclization versus Conjugative Transposition of a Triple Bond.
Authors: Lim Jin Woo , Kim Ko Hoon , Kim Se Hee , Kim Jae Nyoung
Published: August 2013

The judicious choice of leaving group in the propargylic compounds, base, and reaction temperature renders possible the selective preparation of both classes of title compounds.
ChemInform Abstract: Ligand‐ and Base‐Free Pd(II)‐Catalyzed Controlled Switching Between Oxidative Heck and Conjugate Addition Reactions.
Authors: Walker Sarah E. , Boehnke Julian , Glen Pauline E. , Levey Steven , Patrick Lisa , Jordan‐Hore James A. , Lee Ai‐Lan
Published: August 2013

Switching between oxidative Heck and conjugated addition reaction on cyclic alkenes is achieved by a simple switch of the solvent.
ChemInform Abstract: Phosphine‐Mediated Reaction of 3‐Alkyl Allenoates and Diaryl 1,2‐Diones: Efficient Diastereoselective Synthesis of Fully Substituted Cyclopentenones.
Authors: Jose Anu , Lakshmi K. C. Seetha , Suresh Eringathodi , Nair Vijay
Published: August 2013

A novel annulation of allenoate—phosphine zwitterion with acyclic 1,2‐diones affording fully substituted cyclopentenones is reported.
ChemInform Abstract: A Domino Palladium Catalysis: Synthesis of 7‐Methyl‐5H‐dibenzo[a,c][7]annulen‐5‐ones.
Authors: Krishna Jonnada , Reddy Alavala Gopi Krishna , Satyanarayana Gedu
Published: August 2013

The Pd‐catalyzed reaction of ortho‐bromoacetophenone is proposed to proceed via intermolecular homobiaryl coupling and intramolecular aldol condensation to give the title compounds (II) in moderate yields.
ChemInform Abstract: Spirocyclic Dihydropyridines by Electrophile‐Induced Dearomatizing Cyclization of N‐Alkenyl Pyridinecarboxamides.
Authors: Senczyszyn Jemma , Brice Heloise , Clayden Jonathan
Published: August 2013

N‐alkenyl pyridinecarboxamides undergo dearomatizing spirocyclization initiated by pyridine acylation and followed by intramolecular trapping of the resulting pyridinium cation.
ChemInform Abstract: Trianion Synthon Approach to Spirocyclic Heterocycles.
Authors: Perry Matthew A. , Hill Richard R. , Rychnovsky Scott D.
Published: August 2013

A general strategy to construct spirocyclic heterocycles is developed with the key step being a reductive lithiation and cyclization of a nitrile phosphate to form the spirocyclic pyrrolidine, piperidine, or tetrahydrofuran ring.
ChemInform Abstract: Oxetan‐3‐ones from Allenes via Spirodiepoxides.
Authors: Sharma Rojita , Williams Lawrence J.
Published: August 2013

Two reaction methods starting with allene epoxidation are reported.
ChemInform Abstract: Iodoetherification of Isosorbide‐Derived Glycals: Access to a Variety of O‐Alkyl or O‐Aryl Isosorbide Derivatives.
Authors: Berini Christophe , Lavergne Aurelie , Molinier Valerie , Capet Frederic , Deniau Eric , Aubry Jean‐Marie
Published: August 2013

This method gives access to substituted isosorbide derivatives which can be further functionalized.
ChemInform Abstract: The Alkynyl Moiety as a Donor for Donor—Acceptor Cyclopropanes.
Authors: Haubenreisser Stefan , Hensenne Peter , Schroeder Sebastian , Niggemann Meike
Published: August 2013

A calcium‐catalyzed [3 + 2]‐cycloaddition of aldehydes with a new type of quaternary donor site cyclopropanes, bearing an alkyne moiety as the sole donor entity, is presented.
ChemInform Abstract: Gold‐Catalyzed Rearrangement of Allylic Oxonium Ylides: Efficient Synthesis of Highly Functionalized Dihydrofuran‐3‐ones.
Authors: Fu Junkai , Shang Hai , Wang Zhaofeng , Chang Le , Shao Wenbing , Yang Zhen , Tang Yefeng
Published: August 2013

The novel reaction affords the title compounds from readily available starting materials and in a one‐pot procedure.
ChemInform Abstract: Gold(I)‐Catalyzed Alkene Cycloaddition Reactions of Propargyl Acetals.
Authors: Iqbal Naseem , Sperger Christian A. , Fiksdahl Anne
Published: August 2013

This is a comparative study on gold‐catalyzed cycloadditions between alkenes and propargyl acetals or esters yielding a variety of cycloaddition products.
ChemInform Abstract: Rhodium‐Catalyzed Carbocyclization and Chlorosulfonylation of 1,6‐Enynes with Sulfonyl Chlorides.
Authors: Chen Chen , Su Jianhua , Tong Xiaofeng
Published: August 2013

Optimized conditions are elaborated and applied to the reaction of various enynes bearing an N‐linker and to one oxygen analogue (IV) with TosCl.
ChemInform Abstract: One‐Pot and Regiospecific Synthesis of 2,3‐Disubstituted Indoles from 2‐Bromoanilides via Consecutive Palladium‐Catalyzed Sonogashira Coupling, Amidopalladation, and Reductive Elimination.
Authors: Lu Bruce Z. , Wei Han‐Xun , Zhang Yongda , Zhao Wenyi , Dufour Marine , Li Guisheng , Farina Vittorio , Senanayake Chris H.
Published: August 2013

This method can be run as a reaction sequence or as a one‐pot reaction.
ChemInform Abstract: A Mild Entry to Isoindolinones from Furfural as Renewable Resource.
Authors: Caillot Gilles , Hegde Shridhar , Gras Emmanuel
Published: August 2013

A convenient transformation of furfural, its derivatives, or furfurylamine into fused heterocyclic compounds is described.
ChemInform Abstract: Rhodium(III)‐Catalyzed Amidation of Aryl Ketone O‐Methyl Oximes with Isocyanates by C—H Activation: Convergent Synthesis of 3‐Methyleneisoindolin‐1‐ones.
Authors: Zhou Bing , Hou Wei , Yang Yaxi , Li Yuanchao
Published: August 2013

The novel title reaction affords different substituted isoindolin‐1‐ones without any additives and is environmentally benign.
ChemInform Abstract: Calcium‐Catalyzed Cyclopropanation.
Authors: Haven Tobias , Kubik Grzegorz , Haubenreisser Stefan , Niggemann Meike
Published: August 2013

This cascade reaction yields indolyl‐ or benzofuranyl‐substituted 3‐azabicyclo[3.1.0]hexane derivatives with high diastereoselectivity.
ChemInform Abstract: Organocatalytic Michael Addition of Indoles to Isatylidene‐3‐acetaldehydes: Application to the Formal Total Synthesis of (‐)‐Chimonanthine.
Authors: Liu Renrong , Zhang Junliang
Published: August 2013

The reaction tolerates a wide range of substitution and functional groups and proceeds with moderate yields and high enantioselectivities.
ChemInform Abstract: Enantioselective Palladium‐Catalyzed Decarboxylative Allylation of Carbazolones and Indolones: Formal Synthesis of (+)‐Kopsihainanine A.
Authors: Gartshore Christopher J. , Lupton David W.
Published: August 2013

The synthesis of a wide range of different substituted chiral carbazolones and indolones is described.
ChemInform Abstract: Alder‐Ene Reactions of Arynes.
Authors: Karmakar Rajdip , Mamidipalli Phani , Yun Sang Young , Lee Daesung
Published: August 2013

Intramolecular ene reactions of aryne intermediates, generated from the corresponding acyclic alkynes, afford tri‐ or tetracyclic products.
ChemInform Abstract: Synthesis of 4‐Fluoromethylsydnones and Their Participation in Alkyne Cycloaddition Reactions.
Authors: Foster Robert S. , Adams Harry , Jakobi Harald , Harrity Joseph P. A.
Published: August 2013

A highly regioselective synthesis of 5‐fluoromethylpyrazoles is presented.
ChemInform Abstract: Palladium‐Catalyzed Multicomponent Synthesis of 2‐Aryl‐2‐imidazolines from Aryl Halides and Diamines.
Authors: Geden Joanna V. , Pancholi Alpa K. , Shipman Michael
Published: August 2013

The variation of the diamine component also produces 2‐aryl‐1H‐benzimidazoles [e.g. (XII)] and the 2‐aryl‐1,4,5,6‐tetrahydropyrimidine (Xa).
ChemInform Abstract: Weinreb Amide as an Efficient Reagent in the One‐Pot Synthesis of Benzimidazoles and Benzothiazoles.
Authors: Bommegowda Yadaganahalli K. , Lingaraju Gejjalagere S. , Thamas Saji , Kumar Koravangala S. Vinay , Kumara Challanayakanahally S. Pradeepa , Rangappa Kanchugarakoppal S. , Sadashiva Marilinganadoddi P.
Published: August 2013

The cyclocondensation of o‐phenylenediamines or o‐aminothiophenol with Weinreb amides is efficiently promoted by BF3·OEt2 to give the title compounds in good yields.
ChemInform Abstract: One‐Pot Synthesis of 2,4,5‐Trisubstituted 1,2,3‐Triazoles Through the Cascade Reactions of Acid Chlorides, Terminal Acetylenes, Sodium Azide and Aryl Halides.
Authors: Liu Xiang , Li Jihui , Chen Baohua
Published: August 2013

Sonogashira coupling, 1,3‐dipolar cycloaddition, and N‐arylation are successfully combined in a one‐pot cascade reaction affording regioselectively 2,4,5‐trisubstituted 1,2,3‐triazoles.
ChemInform Abstract: Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters by Using Cascade Reactions Catalyzed by an N‐Heterocyclic Carbene.
Authors: Zhou Bing , Luo Zhi , Li Yuanchao
Published: August 2013

An efficient organocatalytic Michael/Michael/lactonization cascade reaction provides an unusual tricyclic oxindole system.
ChemInform Abstract: A Simple Synthesis of 2‐[(Arylmethylidene)hydrazinylidene]‐3‐hydroxy‐4H‐furo [3,2‐c]pyran‐4(3H)‐ones
Authors: Adib Mehdi , Ansari Samira , Zhu Long‐Guan , Rahimi‐Nasrabadi Mehdi
Published: August 2013

via a three‐component reaction of 3‐acetylpyran‐2,4(3H)‐dione, (isocyanoimino)‐triphenylphosphorane and aromatic aldehydes
ChemInform Abstract: Assembling of H5PW10V2O40/MCM‐48 and Studying Its Superior Catalytic Performance in the Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes.
Authors: Tayebee Reza , Maleki Behrouz
Published: August 2013

The title silica‐supported Keggin‐type catalyst allows for a highly efficient and green synthesis of dibenzoxanthone derivatives (III) via condensation of β‐naphthol with aryl aldehydes (8 examples).
ChemInform Abstract: Catalytic Application of Two Novel Sandwich‐Type Polyoxometalates in Synthesis of 14‐Substituted‐14H‐dibenzo[a,j]xanthenes.
Authors: Sheshmani Shabnam
Published: August 2013

A facile and efficient method for the one‐pot synthesis of title dibenzoxanthenes from β‐naphthol and various aldehydes is given using two novel sandwich‐type polyoxometalates as efficient catalysts.
ChemInform Abstract: Yttrium‐Catalyzed Addition of Benzylic C—H Bonds of Alkyl Pyridines to Olefins.
Authors: Guan Bing‐Tao , Wang Baoli , Nishiura Masayoshi , Hou Zhaomin
Published: August 2013

An excellent catalytic system for the ortho‐selective benzylic C—H addition of various dialkyl pyridines is presented.
ChemInform Abstract: Iron‐Catalyzed Oxidative C(3)—H Functionalization of Amines.
Authors: Takasu Noriaki , Oisaki Kounosuke , Kanai Motomu
Published: August 2013

The title reaction is applicable to both cyclic and acyclic substrates under mild conditions using nitroalkenes as coupling partner.
ChemInform Abstract: Modular Pyridine Synthesis from Oximes and Enals Through Synergistic Copper/Iminium Catalysis.
Authors: Wei Ye , Yoshikai Naohiko
Published: August 2013

Redox activity of copper is combined with the iminium activation strategy to construct various pyridine derivatives, including polysubstituted pyridines.
ChemInform Abstract: Expanding Insight into Asymmetric Palladium‐Catalyzed Allylic Alkylation of N‐Heterocyclic Molecules and Cyclic Ketones.
Authors: Bennett Nathan B. , Duquette Douglas C. , Kim Jimin , Liu Wen‐Bo , Marziale Alexander N. , Behenna Douglas C. , Virgil Scott C. , Stoltz Brian M.
Published: August 2013

Novel substrates are applied in the palladium‐catalyzed decarboxylative allylic alkylation.
ChemInform Abstract: Multicomponent Multicatalyst Reactions (MC)2R: One‐Pot Synthesis of 3,4‐Dihydroquinolinones.
Authors: Zhang Lei , Sonaglia Lorenzo , Stacey Jason , Lautens Mark
Published: August 2013

A new Rh/Pd‐catalyzed conjugation‐addition/amidation/amidation reaction sequence is presented.
ChemInform Abstract: Catalyst‐Free Diastereoselective Synthesis of 2‐Methyl‐4‐amino‐1,2,3,4‐tetrahydro‐quinoline Derivatives in Water.
Authors: Wu Lin , Jiang Ran , Yang Jin‐Ming , Wang Shun‐Yi , Ji Shun‐Jun
Published: August 2013

The reaction of anilines with cyclic tert‐enamides affords 2,4‐dibsubstituted tetrahydroquinoline units with complete cis diastereoselectivity.
ChemInform Abstract: Tantalum Catalyzed Hydroaminoalkylation for the Synthesis of α‐ and β‐Substituted N‐Heterocycles.
Authors: Payne Philippa R. , Garcia Pierre , Eisenberger Patrick , Yim Jacky C.‐H. , Schafer Laurel L.
Published: August 2013

α‐Alkylated piperidine, piperazine, and azepane products are prepared in an atom‐economic reaction with excellent regio‐ and diastereoselectivity.
ChemInform Abstract: Mild Metal‐Free Sequential Dual Oxidative Amination of C(sp3)—H Bonds: Efficient Synthesis of Imidazo[1,5‐a]pyridines.
Authors: Yan Yizhe , Zhang Yonghui , Zha Zhenggen , Wang Zhiyong
Published: August 2013

The reaction proceeds via two oxidative C—N couplings and one oxidative dehydrogenation.
ChemInform Abstract: Synthesis of Nucleobase‐Functionalized Morpholino‐Modified Nucleoside Monomers Through Palladium‐Catalyzed Cross‐Coupling Reactions.
Authors: Nandi Bappaditya , Pattanayak Sankha , Paul Sibasish , Sinha Surajit
Published: August 2013

The corresponding halogenated title nucleoside monomers are converted via the Sonogashira and Suzuki cross‐coupling reaction to a wide range of different substituted C‐C‐bond coupled products.
ChemInform Abstract: Selective Synthesis of 1‐Substituted 4‐Chloropyrazolo[3,4‐d]pyrimidines.
Authors: Babu Suresh , Morrill Christie , Almstead Neil G. , Moon Young‐Choon
Published: August 2013

The conversion of 4,6‐dichloropyrimidine‐5‐carboxaldehyde (I) with hydrazines into 1‐substituted pyrazolopyrimidines is presented.
ChemInform Abstract: Au(I)/Ag(I)‐Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2‐c]pyrrolo[1,2‐a]quinazolinones.
Authors: Ji Xun , Zhou Yu , Wang Jinfang , Zhao Linxiang , Jiang Hualiang , Liu Hong
Published: August 2013

The method provides a facile and efficient access to various title compounds including homologues of type (VIII).
ChemInform Abstract: Hydrogen‐Bond‐Directed Enantioselective Decarboxylative Mannich Reaction of β‐Ketoacids with Ketimines: Application to the Synthesis of anti‐HIV Drug DPC 083.
Authors: Yuan Hai‐Na , Wang Shuai , Nie Jing , Meng Wei , Yao Qingwei , Ma Jun‐An
Published: August 2013

This is the first hydrogen‐bond‐directed enantioselective decarboxylative Mannich reaction of β‐ketoacids with ketimines affording quinazolinone derivatives with quaternary stereocenters in high yields and with excellent enantioselectivities using saccharide‐based amino‐thiourea organocatalysts.
ChemInform Abstract: Studies on the Regioselective Nucleophilic Aromatic Substitution (SNAr) Reaction of 2‐Substituted 3,5‐Dichloropyrazines.
Authors: Scales Stephanie , et al. et al.
Published: August 2013

An electron‐withdrawing group in 2‐position of the pyrazine directs the nucleophilic attack preferentially to the 5‐position, whereas electron‐donating groups in 2‐position promote the substitution at the 3‐position.
ChemInform Abstract: Diversely Substituted Triazolo[1,5‐a][1,4]benzodiazepinones: A Post‐Ugi Copper‐Catalyzed Tandem Azide—Alkyne Cycloaddition/Ullmann C—N Coupling Approach.
Authors: Vachhani Dipak D. , Kumar Amit , Modha Sachin G. , Sharma Sunil K. , Parmar Virinder S. , Van der Eycken Erik V.
Published: August 2013

The authors also describe the synthesis of the Ugi four‐component reaction adducts (I), (III), and (V).
ChemInform Abstract: Synthesis of Macrocyclic Ketones Exploiting Palladium‐Catalyzed Activation of Carboxylic Acids as an Enabling Step.
Authors: Kapdi Anant R. , Fairlamb Ian J. S.
Published: August 2013

A novel synthesis of macrocyclic arylketones via Pd‐catalyzed cross‐coupling of arylboronic acids and carboxylic acids, either before or in situ activated by the treatment with disuccinimidyl carbonate, is disclosed.
ChemInform Abstract: Highly Enantioselective Organocatalytic α‐Selenylation of Aldehydes Using Hypervalent Iodine Compounds.
Authors: Kamlar Martin , Vesely Jan
Published: August 2013

The successful α‐selenylation methodology is also applicable to β‐keto esters like (V).
ChemInform Abstract: Daphnane‐Type Diterpenes with Inhibitory Activities Against Human Cancer Cell Lines from Daphne genkwa.
Authors: Li Feifei , Sun Qian , Hong Lili , Li Lingzhi , Wu Yingying , Xia Mingyu , Ikejima Takshi , Peng Ying , Song Shaojiang
Published: August 2013

Four new daphnane‐type diterpenes, genkwadanes A‐D (I)—(IV), resp., are isolated along with 19 known compounds from the flower buds of Daphne genkwa.
ChemInform Abstract: One‐Pot Synthesis of Vicinal Aminoalkanols from Sugar Aldehydes.
Authors: Soengas Raquel G. , Silva Artur M. S.
Published: August 2013

A novel indium catalyzed Henry reaction followed by nitro group reduction gives the title compounds in good to excellent stereoselectivities.
ChemInform Abstract: Synthesis of Fluorinated exo‐Glycals Through Modified Julia Olefination.
Authors: Habib Samuel , Larnaud Florent , Pfund Emmanuel , Lequeux Thierry , Fenet Bernard , Goekjian Peter G. , Gueyrard David
Published: August 2013

Both the protecting groups as well as the presence of BF3·Et2O influence yield and E/Z selectivity of the reaction.
ChemInform Abstract: Stannylene‐Mediated Regioselective 6‐O‐Glycosylation of Unprotected Phenyl 1‐Thioglycopyranosides.
Authors: Maggi Agnese , Madsen Robert
Published: August 2013

The procedure is described to prepare various 1→6‐linked disaccharide thioglycosides and consequently oligosaccharides.
ChemInform Abstract: Synthesis of Indoloazocine Derivatives from a Chiral Indole Amide Stabilized Sulfur Ylide.
Authors: Juarez‐Calderon Maira , Aparicio David M. , Gnecco Dino , Juarez Jorge R. , Orea Laura , Mendoza Angel , Sartillo‐Piscil Fernando , del Olmo Esther , Teran Joel L.
Published: August 2013

The reaction of sulfur ylide (I) with aldehydes is optimized to afford diastereomeric trans‐epoxides (III) selectively.
ChemInform Abstract: Discovery of a Synthetic Aminopeptidase N Inhibitor LB‐4b as a Potential Anticancer Agent.
Authors: Su Li , Jia Yuping , Wang Xuejian , Zhang Lei , Fang Hao , Xu Wenfang
Published: August 2013

The title compound (I) is synthesized starting from benzyl amine and evaluated for its antiinvasion and antiangiogenesis effects.
ChemInform Abstract: Doped Quantum Dots for Chemo/Biosensing and Bioimaging
Authors: Wu Peng , Yan Xiu‐Ping
Published: August 2013

Review: 321 refs.
ChemInform Abstract: Ultrathin Nanostructures: Smaller Size with New Phenomena
Authors: Hu Shi , Wang Xun
Published: August 2013

Review: 148 refs.
ChemInform Abstract: Fluorescence Microscopy Studies of Porous Silica Materials
Authors: Ruehle Bastian , Davies Melari , Bein Thomas , Braeuchle Christoph
Published: August 2013

Review: 99 refs.
ChemInform Abstract: Investigation of Solid/Vapor Interfaces Using Ambient Pressure X‐Ray Photoelectron Spectroscopy.
Authors: Starr D. E. , Liu Z. , Haevecker M. , Knop‐Gericke A. , Bluhm H.
Published: August 2013

Review: 261 refs.
ChemInform Abstract: High Coordination Compounds of Dioxouranium(VI) Derived from Schiff Bases of 4‐Aminoantipyrine
Authors: Agarwal Ram K. , Prasad Surendra , Chand Vimlesh
Published: August 2013

Review: 78 refs.
ChemInform Abstract: Coordination Polymers of Sulfur—Donor Ligands
Authors: Mensforth Emily J. , Hill Matthew R. , Batten Stuart R.
Published: August 2013

Review: 102 refs.
ChemInform Abstract: How to Lose a Bond in Two Ways — The Diradical/Zwitterion Dichotomy in Cycloaromatization Reactions
Authors: Peterson Paul W. , Mohamed Rana K. , Alabugin Igor V.
Published: August 2013

Review: 96 refs.
ChemInform Abstract: Glycopeptide Dendrimers as Pseudomonas aeruginosa Biofilm Inhibitors
Authors: Reymond Jean‐Louis , Bergmann Myriam , Darbe Tamis
Published: August 2013

Review: 60 refs.
ChemInform Abstract: Tailoring Nanohybrids and Nanocomposites for Catalytic Applications
Authors: de Clippel Filip , Dusselier Michiel , Van de Vyver Stijn , Peng Li , Jacobs Pierre A. , Sels Bert F.
Published: August 2013

Review: < 220 refs.
ChemInform Abstract: Recent Advances in the Study of Enzyme Promiscuity in the Tautomerase Superfamily
Authors: Baas Bert‐Jan , Zandvoort Ellen , Geertsema Edzard M. , Poelarends Gerrit J.
Published: August 2013

Review: about 50 refs.
ChemInform Abstract: Flexizyme‐Mediated Genetic Reprogramming as a Tool for Noncanonical Peptide Synthesis and Drug Discovery.
Authors: Passioura Toby , Suga Hiroaki
Published: August 2013

Review: 38 refs.
ChemInform Abstract: 1,2,4,5‐Tetrazines and Azolo[1,2,4,5]tetrazines: Synthesis and Reactions with Nucleophiles
Authors: Tolshchina S. G. , Rusinov G. L. , Charushin V. N.
Published: August 2013

Review: literature data published predominantly from 1995 until 2012; 133 refs.
ChemInform Abstract: Pericyclic [4 + 2] and [3 + 2] Cycloaddition Reactions of Nitroarenes in Heterocyclic Synthesis
Authors: Shevelev S. A. , Starosotnikov A. M.
Published: August 2013

Review: 93 refs.
ChemInform Abstract: Structure of NH‐Benzazoles (1H‐Benzimidazoles, 1H‐ and 2H‐Indazoles, 1H‐ and 2H‐Benzotriazoles)
Authors: Elguero J. , et al. et al.
Published: August 2013

Review: 143 refs.
ChemInform Abstract: Cycloadditions and Condensations as Essential Tools in Spiropyrazoline Synthesis
Authors: Dadiboyena Sureshbabu
Published: August 2013

Review: < 220 refs.
ChemInform Abstract: Synthesis of Oxa‐, Aza‐ and Thia‐Bowls and Cages
Authors: Gharpure Santosh J. , Porwal Suheel K.
Published: August 2013

Review: 147 refs.
ChemInform Abstract: C—B and C—Si Bond‐Forming Reactions by C—H Functionalization
Authors: Szabo K. J.
Published: August 2013

Review: 66 refs.
ChemInform Abstract: C—B and C—Si Bond‐Forming Reactions of C—X Electrophiles
Authors: Murata M.
Published: August 2013

Review: 112 refs.
ChemInform Abstract: Search for Differences in the Complex Forming Abilities of Alkylimidazoles and Making Use of Them
Authors: Lenarcik Beniamin , Radzyminska‐Lenarcik Elzbieta
Published: August 2013

Review: 44 refs.
ChemInform Abstract: Nitrogen‐Containing Privileged Structures and Their Solid‐Phase Combinatorial Synthesis
Authors: Verma Amit , Yadav Mange Ram , Giridhar Rajani , Prajapati Navnit , Tripathi Avinash C. , Saraf Shailendra K.
Published: August 2013

Review: 240 refs.
ChemInform Abstract: From Mechanistic and Kinetic Understanding of Heterogeneously Catalyzed Reactions to Tuning Catalysts Performance
Authors: Kondratenko Evgenii V.
Published: August 2013

Review: 79 refs.
ChemInform Abstract: Intriguing Aspects of Lanthanide Luminescence
Authors: Buenzli Jean‐Claude G. , Eliseeva Svetlana V.
Published: August 2013

Review: 110 refs.
ChemInform Abstract: Mechanisms of Metal‐Catalyzed Dehydrocoupling Reactions
Authors: Waterman Rory
Published: August 2013

Review: 59 refs.
ChemInform Abstract: Computational Methods for the Design of Potent Aromatase Inhibitors
Authors: Favia Angelo Danilo , Nicolotti Orazio , Stefanachi Angela , Leonetti Francesco , Carotti Angelo
Published: August 2013

Review: 103 refs.
ChemInform Abstract: Chirality Sensing Using Stereodynamic Probes with Distinct Electronic Circular Dichroism Output
Authors: Wolf Christian , Bentley Keith W.
Published: August 2013

Review: 92 refs.
Clinical Utility of a Novel Coronary Heart Disease Risk‐Assessment Test to Further Classify Intermediate‐Risk Patients
Authors: Solomon Matthew D. , Tirupsur Ahalya , Hytopoulos Evangelos , Beggs Michael , Harrington Douglas S. , French Cynthia , Quertermous Thomas
Published: August 2013

Background

Current coronary heart disease (CHD) risk assessments inadequately assess intermediate‐risk patients, leaving many undertreated and vulnerable to heart attacks. A novel CHD risk‐assessment (CHDRA) tool was developed for intermediate‐risk stratification using biomarkers and established risk factors to significantly improve CHD risk discrimination.

Hypothesis

Physicians will change their treatment plan in response to more information about a patient's CHD risk level provided by the CHDRA test.

Methods

A Web‐based survey of cardiology, internal medicine, family practice, and obstetrics/gynecology physicians (n = 206) was conducted to assess the CHDRA clinical impact. Each physician was shown 3 clinical vignettes representing community‐based cohort participants randomly selected from 8 total vignettes. For each, the physicians assessed the individual's CHD risk and selected preferred therapies based on the individual's comorbidities, physical examination, and laboratory results. The individual's CHDRA score was then provided and the physicians were queried for changes to their initial treatment plans.

Results

After obtaining the CHDRA result, 70% of the physician responses indicated a change to the patient's treatment plan. The revised lipid‐management plans agreed more often (74.6% of the time) with the current Adult Treatment Panel III guidelines than did the original plans (57.6% of the time). Most physicians (71.3%) agreed with the statement that the CHDRA result provided information that would impact their current treatment decisions.

Conclusions

The CHDRA test provided additional information to which physicians responded by more often applying appropriate therapy and actions aligned with guidelines, thus demonstrating the clinical utility of the test.
CONFECT: Conformations from an Expert Collection of Torsion Patterns
Authors: Schärfer Christin , Schulz‐Gasch Tanja , Hert Jérôme , Heinzerling Lennart , Schulz Benjamin , Inhester Therese , Stahl Martin , Rarey Matthias
Published: August 2013

The generation of sets of low‐energy conformations for a given molecule is a central task in drug design. Herein we present a new conformation generator called CONFECT that builds on our previously published library of torsion patterns. Conformations are generated as well as ranked by means of normalized frequency distributions derived from the Cambridge Structural Database (CSD). Following an incremental construction approach, conformations are selected from a systematic enumeration within energetic boundaries. The new tool is benchmarked in several different ways, indicating that it allows the efficient generation of high‐quality conformation ensembles. These ensembles are smaller than those produced by state‐of‐the‐art tools, yet they effectively cover conformational space.
Evaluating Prodrug Strategies for Esterase‐Triggered Release of Alcohols
Authors: Perez Christian , Daniel Kevin B. , Cohen Seth M.
Published: August 2013

Prodrugs are effective tools in overcoming drawbacks typically associated with drug formulation and delivery. Those employing esterase‐triggered functional groups are frequently utilized to mask polar carboxylic acids and phenols, increasing drug‐like properties such as lipophilicity. Herein we detail a comprehensive assessment for strategies that effectively release hydroxy and phenolic moieties in the presence of an esterase. Matrix metalloproteinases (MMPs) serve as our proof‐of‐concept target. Three distinct ester‐responsive protecting groups are incorporated into MMP proinhibitors containing hydroxy moieties. Analytical evaluation of the proinhibitors demonstrates that the use of a benzyl ether group appended to the esterase trigger leads to considerably faster kinetics of conversion and enhanced aqueous stability when compared with more conventional approaches where the trigger is directly attached to the inhibitor. Biological assays confirm that all protecting groups effectively cleave in the presence of esterase to generate the active inhibitor. The superior reaction‐based prodrug strategies presented here should serve as a platform for esterase‐responsive prodrug design in the future.
In silico Optimization of a Fragment‐Based Hit Yields Biologically Active, High‐Efficiency Inhibitors for Glutamate Racemase
Authors: Whalen Katie L. , Chau Anthony C. , Spies M. Ashley
Published: August 2013

A novel lead compound for inhibition of the antibacterial drug target, glutamate racemase (GR), was optimized for both ligand efficiency and lipophilic efficiency. A previously developed hybrid molecular dynamics–docking and scoring scheme, FERM‐SMD, was used to predict relative potencies of potential derivatives prior to chemical synthesis. This scheme was successful in distinguishing between high‐ and low‐affinity binders with minimal experimental structural information, saving time and resources in the process. In vitro potency was increased approximately fourfold against GR from the model organism, B. subtilis. Lead derivatives show two‐ to fourfold increased antimicrobial potency over the parent scaffold. In addition, specificity toward B. subtilis over E. coli and S. aureus depends on the substituent added to the parent scaffold. Finally, insight was gained into the capacity for these compounds to reach the target enzyme in vivo using a bacterial cell wall lysis assay. The outcome of this study is a novel small‐molecule inhibitor of GR with the following characteristics: Ki=2.5 μM, LE=0.45 kcal mol−1 atom−1, LiPE=6.0, MIC50=260 μg mL−1 against B. subtilis, EC50, lysis=520 μg mL−1 against B. subtilis.
Octahedral Noble‐Metal Nanoparticles and Their Electrocatalytic Properties
Authors: Wang Chenyu , Fang Jiye
Published: August 2013

Octahedrally shaped noble‐metal nanocrystals are fascinating for their unique properties, such as electrocatalytic, catalytic, plasmonic, and optical behavior, owing to their exclusively exposed {111} facets; Oh symmetric structure; and close‐packed surface atoms in low‐index surface categories, which are normally stable in a reaction. A series of protocols in the preparation of noble‐metal nano‐octahedra through a wet‐chemical synthetic strategy have been developed in recent years. Herein, advances in synthetic approaches and mechanistic studies of noble‐metal nano‐octahedra are systematically discussed and key factors, including reduction kinetics, selective capping, and epitaxial growth, are outlined. Their unique performance as advanced electrocatalysts towards fuel‐cell reactions is highlighted as well.
Local translation in neuronal processes—in vivo tests of a “heretical hypothesis”
Authors: Perry Rotem B. , Fainzilber Mike
Published: August 2013

Intracellular trafficking and localization of mRNA is a fundamental feature of living cells, suggesting that localized mRNA translation should enable subcellular regulation of the proteome. Such localized regulation may be of particular importance in highly polarized cells such as neurons, where the requirement for a specific protein can be at a site far distant from the nucleus. Although dendritic and synaptic protein syntheses are well‐established phenomena, the apparent paucity of ribosomes in early studies on mature vertebrate axons generated significant skepticism regarding the possibility of protein synthesis within axons. Here, we summarize recent findings in genetically engineered mouse models that support a role for local translation in axonal expression of β‐actin and importin β1 in injured adult sensory neurons in vivo. These definitive confirmations of mammalian axonal protein synthesis in both transgenic and subcellular knockout models should direct further attention to the diverse roles suggested for local protein synthesis in axonal physiology. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 74: 210–217, 2014
Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord
Authors: Morimura Rii , Nozawa Keisuke , Tanaka Hideomi , Ohshima Toshio
Published: August 2013

Dpysls (CRMPs) that were initially identified as mediator proteins of Semaphorin3a (Sema3a) signaling are involved in neuronal polarity and axon elongation in cultured neurons. Previous studies have shown that knockdown of neuropilin1a, one of the sema3a receptors, exhibited ectopic primary motor neurons (PMNs) outside of the spinal cord in zebrafish. However, downstream molecules of sema3a signaling involved in the positioning of motor neurons are largely unknown. Here, we addressed the role of Dpysl2 (CRMP2) and Dpysl3 (CRMP4) in the positioning of PMNs in the zebrafish spinal cord. We found that the knockdown of dpysls by antisense morpholino oligonucleotides (AMO) causes abnormal positioning of caudal primary (CaP) motor neurons outside the spinal cord. The knockdown of cdk5 and dyrk2 by AMO also caused similar phenotype in the positioning of CaP motor neurons, and this phenotype was rescued by co‐injection of phosphorylation‐mimic type dpysl2 mRNA. These results suggest that the phosphorylation of Dpysl2 and Dpysl3 by Cdk5 and Dyrk2 is required for correct positioning of CaP motor neurons in the zebrafish spinal cord. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 911–920, 2013
An Efficient Homogeneous Chloro–Aluminum–[N2O2] Catalyst for the Coupling of Epoxides with Carbon Dioxide
Authors: Fuchs Monica A. , Altesleben Christiane , Zevaco Thomas A. , Dinjus Eckhard
Published: August 2013

The coupling reaction of epoxides and CO2 is in the focus of many research activities in academia as well as in the industry. In this contribution we report on a versatile aluminum‐based homogeneous catalyst utilizing an easy‐to‐synthesize N2O2 ligand system in combination with various cocatalysts, all of them producing pure alternating poly(cyclohexene carbonate)s with Mn values in the range 10000–15000 g mol–1. This system also efficiently catalyzes the formation of propylene carbonate.
Redox‐Active Triazolium‐Derived Ligands in Nucleophilic Fe‐Catalysis – Reactivity Profile and Development of a Regioselective O‐Allylation
Authors: Klein Johannes E. M. N. , Holzwarth Michael S. , Hohloch Stephan , Sarkar Biprajit , Plietker Bernd
Published: August 2013

Triazolium‐derived N‐heterocyclic carbene (aNHC) ligands, which are readily accessible by deprotonation of the corresponding triazolium salts, proved to be versatile ligands in diverse allylic substitution reactions. The corresponding triazolium salts are formed from azides and alkynes through the application of 1,3‐dipolar cycloaddition and N‐alkylation reactions. The unique property of these ligands is to be zwitterionic in their liberated form and to act as strong redox‐active σ‐donor ligands. By virtue of these qualities, these ligands enable the development of an unprecedented Fe‐catalyzed regioselective aryloxylation of allylic carbonates.
Catalytic Synthesis of Functional Silicon‐Stereogenic Silanes through Candida antarctica Lipase B Catalyzed Remote Desymmetrization of Silicon‐Centered Diols
Authors: Lu Xing , Li Li , Yang Wei , Jiang Kezhi , Yang Ke‐Fang , Zheng Zhan‐Jiang , Xu Li‐Wen
Published: August 2013

A series of silicon‐containing diols are synthesized and used in lipase‐catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon‐stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL‐B) (up to 90:10 er).
Oncogenic roles of PRL‐3 in FLT3‐ITD induced acute myeloid leukaemia
Authors: Park Jung Eun , Yuen Hiu Fung , Zhou Jian Biao , Al‐aidaroos Abdul Qader O. , Guo Ke , Valk Peter J. , Zhang Shu Dong , Chng Wee Joo , Hong Cheng William , Mills Ken , Zeng Qi
Published: August 2013

FLT3‐ITD mutations are prevalent mutations in acute myeloid leukaemia (AML). PRL‐3, a metastasis‐associated phosphatase, is a downstream target of FLT3‐ITD. This study investigates the regulation and function of PRL‐3 in leukaemia cell lines and AML patients associated with FLT3‐ITD mutations. PRL‐3 expression is upregulated by the FLT3‐STAT5 signalling pathway in leukaemia cells, leading an activation of AP‐1 transcription factors via ERK and JNK pathways. PRL‐3‐depleted AML cells showed a significant decrease in cell growth. Clinically, high PRL‐3 mRNA expression was associated with FLT3‐ITD mutations in four independent AML datasets with 1158 patients. Multivariable Cox‐regression analysis on our Cohort 1 with 221 patients identified PRL‐3 as a novel prognostic marker independent of other clinical parameters. Kaplan–Meier analysis showed high PRL‐3 mRNA expression was significantly associated with poorer survival among 491 patients with normal karyotype. Targeting PRL‐3 reversed the oncogenic effects in FLT3‐ITD AML models in vitro and in vivo. Herein, we suggest that PRL‐3 could serve as a prognostic marker to predict poorer survival and as a promising novel therapeutic target for AML patients.
High‐mode buckling responses of buckling‐restrained brace core plates
Authors: Wu An‐Chien , Lin Pao‐Chun , Tsai Keh‐Chyuan
Published: August 2013

Cyclic loading tests and finite element analyses on six novel all‐steel buckling‐restrained braces (BRBs) are conducted using different loading patterns to investigate the core plate high‐mode buckling phenomenon. The proposed BRB is composed of a core member and a pair of identical restraining members, which restrains the core member by using bolted shim spacers. The design of the proposed BRB allows the core plate to be visually inspected immediately following a major earthquake. If necessary, the pair of restraining members can be conveniently disassembled, and the damaged core plate can be replaced. Test results indicate that the proposed BRBs can sustain large cyclic strain reversals and cumulative plastic deformations in excess of 400 times the yield strain. Experimental and analytical results confirm that the high‐mode buckling wavelength is related to the core plate thickness and the applied loading patterns. The larger the axial compressive strain is applied, the shorter the high‐mode buckling wavelength would be developed. The buckling wavelength is about 12 times the core plate thickness when the high‐mode buckling shape is fully developed. However, it reduces to about 10 times the core plate thickness when a compressive core strain reaches greater than 0.03. The high‐mode bucking wavelength can be satisfactorily predicted using the proposed method or from the finite element analysis. Copyright © 2013 John Wiley & Sons, Ltd.
Reconstructing a prehistoric topography using legacy point data in a depositional environment
Authors: Vermeer Julian A. M. , Finke Peter A. , Zwertvaegher Ann , Gelorini Vanessa , Bats Machteld , Antrop Marc , Verniers Jacques , Crombé Philippe
Published: August 2013

Reconstruction of past topography is an essential step towards the understanding of past landscapes in terms of biophysical patterns and processes and man–landscape interactions by archaeologists, geomorphologists, geologists and soil scientists. Landscape reconstructions can be based on process knowledge, on data, or on a combination of both. In this case study we focus on a data‐based approach, where knowledge on the geological history is used to interpret and exploit legacy data. As part of a landscape reconstruction of a large area of 584 km2a map of the elevation near 10 000 BC was produced. Starting from a present‐day grid digital elevation model (GDEM) that was filtered for human influences, we identified the thickness of accumulated sediments over the Holocene, mapped these and corrected the GDEM. To map the thickness of Holocene sediments we used 72 (OSL and14C) dated sediment samples, 731 recent profile descriptions and 3288 legacy profile descriptions. Protocols were formulated based on literature and local correlative studies to convert the legacy profile descriptions into estimates of the thickness of Holocene sediments, with an estimate of the precision. The method of Kriging with uncertain data was applied to obtain a map. Validation at 200 independent test locations with certain data showed a mean error of –6 cm and a standard deviation or error of 16 cm, which was in accordance with the estimated precision of 16 cm. The resulting map indicated zones with marked change that could be studied in more detail. Future reconstructions could employ both process knowledge and data by combining landscape genesis models with legacy data to map model errors and thus increase the quality of the reconstruction. Copyright © 2013 John Wiley & Sons, Ltd.
Effects of landfill leachate treatment on hepatopancreas of Armadillidium vulgare (Crustacea, Isopoda)
Authors: Manti Anita , Canonico Barbara , Mazzeo Roberto , Santolini Riccardo , Ciandrini Eleonora , Sisti Davide , Rocchi Marco Bruno Luigi , Nannoni Francesco , Protano Giuseppe , Papa Stefano
Published: August 2013

The major environmental impact of landfills is emission of pollutants via the leachate and gas pathways. The hepatopancreas of the terrestrial isopod Armadillidium vulgare (Isopoda, Crustacea, Latreille 1804) plays an important role in the bioaccumulation of contaminants, such as heavy metals. To evaluate the effects of landfill leachate treatment, 2 different approaches were applied: 1) the detection of accumulation of trace elements (As, Cd, Cr, Cu, Sb, Zn, Pb, Ni, V) in hepatopancreatic cells, and 2) the evaluation of biological effect of contaminants on fresh hepatopancreatic cells by flow-cytometric analyses. The presence of 2 different cell types (herein referred to as “small” [S] cells and “big” [B] cells, in agreement with the literature based on morphological examinations) was detected for the first time by flow cytometry, which also highlighted their different response to stress stimuli. In particular, B cells appeared more sensitive to landfill leachate treatment, being more damaged in the short term, while S cells seemed more adaptive. Furthermore, S cells could represent a pool from which they are able to differentiate into B cells. These findings were also confirmed by principal component analyses, underlining that S SYBR Green I bright cells correlate with specific chemicals (Ca, Cu, Co), confirming their resistance to stress stimuli, and suggesting that the decrease of specific cell types may prime other elements to replace them in a homeostasis-preservation framework. Environ Toxicol Chem 2013;32:2593–2601. © 2013 SETAC