bluuebunny/crossref_metadata_2025 huggingface dataset:
Expansion of Japanese Ceramic Industry in Manchuria and Colonial Exploitation in the Early 20th Century
Authors: Kim Eun-Kyoung
Published: May 2024

Towards the end of the Qing Dynasty and into the early Republic of China, the ceramics industry, a vital component of China’s economy, faced stagnation. In response, the central government embarked on modernization efforts to rejuvenate the industry, achieving tangible progress such as establishing modern systems through the Porcelain Company. Despite these efforts, Japan aggressively exported goods to China, aiming to expand its trade and dominate the Chinese market. Additionally, the ceramics department within the central laboratory of the South Manchurian Railway Company was established to mass-produce ceramics for heavy chemical use, utilizing resources from Manchuria to meet the substantial material demands for foreign invasions. Furthermore, modern Japanese apprenticeships were extended to Chinese laborers to meet the daily ceramic needs of Japanese residents in the northeastern region. Thus, on the surface, the ceramics industry in the Northeast appeared to have expanded in various aspects.The Chinese ceramics industry underwent significant changes in production scale, distribution, technology, and infrastructure. However, these developments were not the result of natural growth but rather arose from the allocation of raw materials and products essential for Japan’s ceramics sector. Moreover, they were fueled by the harsh exploitation of laborers in the northeastern ceramics industry, serving as a key aspect of Japan’s broader strategy of mass colonization.
Action interpretation determines the effects of go/no-go and approach/avoidance actions on stimulus evaluation
Authors: Chen Zhang , Van Dessel Pieter
Published: May 2024

Executing go/no-go or approach/avoidance responses toward a stimulus can change its evaluation. To explain these effects, some theoretical accounts propose that executing these responses inherently triggers affective reactions (i.e., action execution), while others posit that the evaluative influences originate from interpreting these responses as valenced actions (i.e., action interpretation). To test the role of action execution and action interpretation in these evaluative effects, we developed a novel training task that combined both go/no-go and approach/avoidance actions orthogonally. Participants either responded or did not respond (i.e., go/no-go) to control a shopping cart on screen, and as a result, either collected or did not collect (i.e., approach/avoidance) certain food items. When the task instructions referred to the go/no-go actions (Experiment 1, N = 148), we observed an effect of these actions. Participants evaluated no-go items less positively than both go and untrained items. No effect of approach/avoidance actions was observed. Contrarily, when the task instructions referred to the approach/avoidance actions (Experiment 2, N = 158), we observed an approach/avoidance effect. Participants evaluated approached items more positively and avoided items less positively than untrained items. No effect of go/no-go actions was observed. This suggests that action interpretation determined whether go/no-go or approach/avoidance actions influenced stimulus evaluation, when the same motor responses were made. Further examination of the role of action interpretation can inform theories of how actions influence stimulus evaluation, and facilitate the use of these interventions in applied settings.
Ethical implications of digital gaming interventions for mental health: Systematic review and critical appraisal
Authors: Pavarini Gabriela , Reay Emma , Crowe Elvina , Bhui Kamaldeep , Fazel Mina , Ma Minhua , Parker Michael , Smith Lindsey M.
Published: May 2024

Background: In 2020, two digital game-based therapeutic interventions were clinically approved, raising ethical questions about ‘games on prescription’. Aims: This article systematically reviews the opportunities, concerns, and ethical considerations in literature around applied digital gaming interventions for mental health. Methods: The protocol was registered at INPLASY (202330035). Electronic databases Pubmed, PsycNet, EthxWeb, Scopus and journal 'Game Studies' were searched from 1993 to 2023, identifying 5,502 papers combining concepts around games, ethics, and mental health. 158 full texts were screened and 42 included in this review. Using custom rating categories, we identified 10 papers addressing ethical issues as a ‘core’ focus, with the remaining 32 papers mentioning ethics either ‘prominently’ or ‘tangentially’. Results: Opportunities at a public level included improved availability and accessibility of mental health interventions. Concerns included negative attitudes towards digital games and potential exclusion of certain groups due to required infrastructure and skills. For user communities, papers mentioned the potential for enhanced care due to increased social connection, autonomy, and control. However, concerns included harms arising from physical side effects, addiction, miscommunication, reality/fantasy confusion, poor clinical design, social/therapeutic isolation, and data privacy. At game product and policy level, the significant regulatory vacuum surrounding digital interventions was cause for concern, as were challenges arising from the complex process and financial cost of production. Conclusions: There is urgent need for more ethical reflection on gamifying mental health interventions. Most papers did not discuss socio-political perspectives, revealing opportunities for humanities scholarship and the need for interdisciplinary collaboration and stakeholder engagement.
CONTROL CON MEDIOS FÍSICOS DE LA HIPERTERMIA EN NIÑOS EN EL SERVICIO DE PEDIATRÍA
Authors: Jimbo Suarez Anabel Stefania , Azanza Atariguana Ginger Lisbeth , Floreano Solano Lilian Marisol
Published: May 2024

Introducción:  Temperatura corporal es equilibrio entre la producción de calor y su pérdida, permite mantener su homeostasis y fuerza vital, considerándose hipertermia 37,5-38,5ºC; fiebre alta 38,5-39,5ºC; y de 39,5-40,0ºC fiebre maligna. Objetivo: Determinar el control de la temperatura por medio de dos técnicas. Métodos: Investigación cuantitativa con enfoque cuasi experimental, transversal, población de 100 niños internados en emergencia y pediatría, con hipertermia; variables de temperatura corporal, control de temperatura control de la hipertermia utilizando dos técnicas: Uso de paños de agua corriente en zonas de mayor calor corporal en frente, axilas, abdomen y zona inguinal; y Baño, sumergiendo al niño en una tina con agua tibia entre 32,2 a 35ºC, hasta el cuello, frotando con firmeza todo el cuerpo durante 20 o 30 minutos. Para la comprobación de hipótesis, se utilizó la Prueba Z, 95% de nivel de confianza, valor p<0.05, estadígrafo de contrastación 1,96; resultado superior a este valor, se acepta hipótesis alterna, resultado menor se acepta la hipótesis nula. Resultados: 56% de niños son de 1 a 4 años, sin diferencia entre el sexo, patologías respiratorias con el 60%. Se acepta la hipótesis alterna: Existencia de diferencia significativa en el control de temperatura en niños. Conclusiones: la disminución de la temperatura corporal es menor en la técnica del baño con 45 minutos, por lo que se recomienda esta técnica aplicarla en la hospitalización como medida de control de la hipertermia en los niños, de tal forma que se previene las complicaciones como es las convulsiones, deshidratación y rabdomiolisis.
ACTITUDES Y AFRONTAMIENTO ANTE LA MUERTE DE LOS ESTUDIANTES DE ENFERMERÍA
Authors: Masaquiza Chango Jessenia Maribel , Guarate Coronado Yeisy Cristina
Published: May 2024

Introducción: En las instituciones de salud, el equipo de salud y los estudiantes de enfermería, durante sus prácticas hospitalarias presencian la muerte, considerada esta como un proceso que existe en la vida, por lo tanto, la actitud y afrontamiento que se tome ante esta situación es importante. Objetivo. Determinar las actitudes y afrontamiento ante la muerte de los estudiantes de enfermería. Métodos. Enfoque cuantitativo, con diseño no experimental, de corte transversal. Para recolectar la información se aplicó la Escala de Miedo a la Muerte de Collett – Lester y Escala Bugen de Afrontamiento de la Muerte a una muestra censal de 74 internos de enfermería, la muestra fue censal. Resultados. Se determinó que el 100% de los participantes del estudio tiene un afrontamiento inadecuado a la muerte. El 28% tiene una actitud de miedo a la muerte; el 22% indica una actitud de aceptación de escape; un 20% manifiesta una actitud de evitación de la muerte. Finalmente, el 15% ha manifestado actitudes de aceptación de acertamiento y aceptación neutral. Conclusiones. Los estudiantes de enfermería tienen actitudes de miedo ante la muerte, así como un afrontamiento inadecuado ante la misma, lo que significa que al estar en contacto con el paciente al final de su vida le afecta emocionalmente, llevándolos a sentirse culpable de no haber logrado prolongar la vida del paciente.
Présentation
Authors: Banyś Wiesław
Published: May 2024

Ce numéro de Neophilologica est consacré à la mémoire de Gaston Gross, membre du Comité Scientifique de la revue et son président d'honneur. Le texte présente les contributions de Gaston Gross en linguistique et en coopératio  linguistique franco-polonaise, ainsi qu'une présentation sommaire de chaque texte formant ce numéro de Neophilologica.
Russian Free Phrasal Indefinite Pronouns
Authors: Mel'čuk Igor
Published: May 2024

The paper describes Russian phrasal indefinite pronouns: both 1) phraseologized (= collocational), such as koe-kto ≈ ‘someone’, Bog znaet kto ‘God knows who’, kto ugodno ‘whoever’ or kto by to ni bylo ‘no matter who’, and 2) free, such as {Ja vstretil} nikto iz tvoix druzej ne dogadaetsja kogo ‘{I met} none of your friends will guess whom’ (a.k.a. syntactic amalgams). Three lexical entries are presented: for the indefinite pronominal lexeme kto1 ≈ ‘-body; -one’, for the premodifying indefi­niteness type marker idiom ˹Bog znaet˺ ‘God knows’, and for the postmodifying indefiniteness type marker particle -to4 ≈ ‘some’. Formal representations of collocational and free phrasal indefi­nite pronouns at three levels of linguistic representation (semantic, deep-syntactic and surface-syntactic) are given, as well as rules for constructing both types of pronouns.
Dampak Marketplace Layout Design, Sales Promotion dan Customer Review Terhadap Impulse Buying
Authors: Isalman Isalman , Putera Asrip
Published: May 2024

The Shopee marketplace continues to show its existence as the marketplace with the most visitors. The distinctive color combination and well-arranged navigation menu can provide a different feel when visiting the maketplace. Information about various products can be seen very clearly on the main homepage, and shopping promo offers are also clearly visible on the slider screen on the main marketplace screen. The marketplace layout is also supported by the existence of a customer review navigation feature as a window for customer reviews of products and services that have been received. Shopee seems to understand how urgent the role of product information and customer reviews is in minimizing risks and supporting unplanned purchasing decisions. Therefore, this research aims to determine the impact of marketplace layout design, sales promotions and customer reviews to increase impulse buying. Research was conducted among Y generation in Kendari City who shopped at the Shopee marketplace. The total sample is 160 respondents. A questionnaire with a Likert scale was used as a data collection tool. Data were analyzed by multiple linear regression using SPSS software. The results of data analysis show that marketplace layout design does not have a significant influence on impulse buying. Meanwhile, sales promotion and customer reviews have a significant positive influence on impulse buying. These findings provide information to marketplace managers and sellers about the urgency of the role of sales promotion as a short-term strategy in accelerating impulse buying. Apart from that, the existence of a customer review feature on the marketplace website can contribute to impulse buying. So it becomes urgent to provide stimulus, such as giving rewards or incentives to customers who have purchased to be able to provide reviews of the products and services they receive.
Years of Healthy Life among Older Adults in Brazil: An Analysis Based on the Global Activity Limitation Indicator, 1998 and 2008
Authors: Alves Luciana Correia , Castro Santos Camargos Mirela , Jorge Machado Carla
Published: May 2024

The aim of the study was to calculate life expectancy and Healthy Life Expectancy (HLY) through a Global Activity Limitation Indicator (GALI) proxy among Brazilian older adults according to sex for the years 1998 and 2008. The study was carried out using data from the Brazilian National Household Sample Survey (PNAD) and from Abbreviated Life Tables in 2000 and 2010 from Brazilian Institute of Demographic Geography and Statistics (IBGE) by sex. The activity limitation-free life expectancy was estimate based on the GALI for both sexes using the Sullivan method. The results showed an increase in life expectancy in the period for both sexes. The time of life without activity limitations in 2008 has decreased for men. For women, a reduction in percentage of the time lived without activity limitation has been shown. A small  advantage in favor of men compare to women’s health was found. Comparing the two periods, the proportion of years expected to be lived without activity limitation was higher in 1998 than in 2008 and for both sexes. There are still many uncertainties about how the country is actually ageing. Given this context, an effort to maintain constant health monitoring through different indicators such as GALI is essential. At the same time, strengthening local and regional policies, aiming to build solid paths and mechanisms to promote an active and healthy ageing of its population must be a target.
Exploring the Intersection of Quantum Mechanics and Human Psychology
Authors:   College of Medicine and Health Sciences, Palestine Polytechnic University, Hebron, Palestine, Alzeer Jawad ,   Swiss Scientific Society for Developing Countries, Zürich, Switzerland, Benmerabet Hamid
Published: May 2024

Understanding the complexities of human psychology and addressing mental health challenges require a multidimensional approach that transcends conventional boundaries. This manuscript explores the intersection between quantum mechanics and human science, proposing novel insights into the dynamics of human traits and behaviour. By examining the principles of quantum mechanics, particularly superposition, we hypothesize that human traits may exist in a state of potentiality, coexisting with their respective values. This perspective suggests that individuals possess a spectrum of traits, and deliberate effort plays a crucial role in determining their manifestation. Drawing inspiration from quantum mechanics, we advocate for a proactive approach to nurturing positive traits and addressing destructive tendencies. This involves recognizing the power of choice, fostering self-awareness, and actively engaging in personal growth initiatives. We discuss the implications of trait activation and highlight the importance of voluntary effort in shaping behaviour and character. Additionally, we explore practical strategies for navigating psychological challenges. This manuscript underscores the potential of interdisciplinary inquiry to inform innovative approaches to psychological intervention and therapy. Through further empirical research and theoretical exploration, we can unlock new perspectives and strategies for enhancing human flourishing and addressing the complexities of the human psyche.
Pengendalian Intern Pelunasan Gadai pada PT. Pegadaian (Persero) Unit Pembantu Cabang (UPC) Jenggawah Kabupaten Jember
Authors: Candra Dewi Monika Oktaria , Lestari Hari Budi , Wiguna Ardhitya Alam
Published: May 2024

This research aims to describe  the internal control of pawn settlement at PT. Pegadaian (Persero) Jenggawah Branch Supporting Unit (UPC), Jember Regency. The method used in this research is descriptive qualitative. Data collection techniques were carried out using observation, documentation, literature review and interview methods. Then the findings were analyzed by comparing the results of the research with the previously existing theories related to internal control of mortgage settlement. The results of the study show that the internal control of mortgage settlement at PT. Pegadaian (Persero) Jenggawah Branch Support Unit (UPC) in Jember Regency is generally according to theory. From the 4 (four) elements that serve as benchmarks for the suitability of internal control for repayment of pawns based on theory, there is only 1(one) element that is not appropriate, namely the element of related functions. Information regarding credit can be added for further research.
PENANGKAPAN LARVA IKAN SIDAT (Anguilla spp.) DI PERAIRAN PANTAI MALUNDA, SULAWESI BARAT
Authors: Tenriware  , Nur Muhammad , Jabbar Firmansyah Bin Abd , Husniah  , Jufri Ady
Published: May 2024

Penelitian ini bertujuan untuk mengidentifikasi kelimpahan ikan sidat di Perairan Pantai Malunda, Provinsi Sulawesi Barat. Penangkapan larva sidat dilakukan di Perairan Pantai Malunda Provinsi Sulawesi Barat. Alat tangkap berupa seser (hand scoop net) dengan ukuran mata jaring 1 mm digunakan dalam pengambilan sampel. Kegiatan sampling dilakukan sebulan sekali pada malam hari setiap bulan gelap. Sampel dari hasil tangkapan dimasukkan dalam ember yang berisi air sungai yang dilengkapi dengan aerator, selanjutnya dibawa ke laboratorium terpadu Universitas Sulawesi Barat dalam keadaan hidup untuk diidentifikasi dan pengukuran panjang dan berat. Pengukuran kualitas air meliputi salinitas, pH, suhu, dan TDS dilakukan setiap pengambilan sampel ikan. Metode identifikasi berdasarkan karakter kunci Anal Dorsal Vertebrata (ADV) digunakan dengan menghitung jumlah ruas tulang punggung anodorsal (anodorsal vertebrae) dan panjang anodorsal. Hasil penelitian ini menunjukkan bahwa larva sidat yang ditemukan baik di Perairan Pantai Malunda terdiri dari satu jenis yaitu Anguilla marmorata. Anguilla marmorata yang diperoleh memiliki jumlah ruas tulang anodorsal berkisar antara 14- 18. Kelimpahan ikan sidat tertinggi pada diperoleh pada Bulan Agustus. Kondisi perairan di Perairan Pantai Malunda masih tergolong baik bagi ikan sidat untuk hidup dan berkembang secara optimal.
INTEGRATIVE BIOINFORMATICS APPROACHES TO THE UNDERSTANDING OF CHRISTININ MOLECULAR MECHANISM AS JANUS KINASE (JAK) INHIBITORS FOR SUPPRESSING HYPERINFLAMMATION IN COVID-19
Authors: F. Darusman  , Fakih T.M. , Ramadhan D.S.F.
Published: May 2024

COVID-19 is a significant worldwide health concern. The exaggerated immune response known as the "cytokine storm" is a key factor in this illness, and there are potential ways to address it. Janus kinase (JAK) inhibitors are a type of medication that might reduce inflammation and improve the body's production of antibodies. Pharmacokinetic profiles, toxicity characteristics, biological activities prediction, and molecular docking simulation will be conducted to discover, assess, and investigate the molecular interactions of Christinin compounds, including Christinin-A, Christinin-B, Christinin-C, and Christinin-D derived from Ziziphus spina-christi leaves as Janus kinase (JAK) inhibitors using bioinformatics approaches. Based on the molecular docking simulation, it can be concluded that the Christinin compound has a molecular interaction with Janus Kinase (JAK). However, Christinin-A and Christinin-C compounds have better affinity than Christinin-B and Christinin-D compounds, with binding free energy values of −7.59 kcal/mol and −5.37 kcal/mol, respectively. Therefore, these two compounds can be used as candidates for Janus Kinase (JAK) inhibitors in preventing hyperinflammation in the COVID-19 infectious disease
Lantana trifolia ACTIVATED CARBON FOR REMOVAL OF 2-PHENOXYETHANOIC ACID: NEURAL NETWORK OPTIMIZATION APPROACH
Authors: Ilavenil K. K. , V. Senthilkumar  , R. Pichailakshmi
Published: May 2024

This study uses a low-cost Lantana trifolia-activated carbon and an artificial neural network (ANN) to predict wastewater having 2-phenoxyethanoic acid adsorption. To forecast 2-phenoxyethanoic acid elimination efficiency, MATLAB uses a three-layer feed-forward neural network, a Multilayer Perceptron (MLP), with backpropagation. The neural network is trained with three input parameters: 2-phenoxyethanoic acid concentration, adsorbent amount, and contact duration. Root mean square error and linear regression estimate the removal effectiveness of 2- phenoxyethanoic acid. The findings reveal that the generated ANN models for 2-phenoxyethanoic acid adsorption accurately match empirical data on pollutant removal efficacy. This suggests that low-cost Lantana trifolia activated carbon may be used to estimate 2-phenoxyethanoic acid absorption using the neural network technique.
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF IPRATROPIUM BROMIDE AND MOMETASONE FUROATE USING RP-HPLC
Authors: Deshmukh P. P. M. , Giri P. T. , Ghogare A. B. , Waghmare N. V. , S. Kale  , Singh S. K. , B. Kumar  , Baghel D. S. , S. Singh  , K. Sudhakar  , Pandey N. K.
Published: May 2024

The present work aimed to develop a suitable, specific, simple, precise, robust, and reproducible analytical method using RP-HPLC for simultaneous estimation of Ipratropium bromide and Mometasone furoate. The separation was carried out using mobile phase Acetonitrile: Phosphate buffer (pH modified up to 3.7 by orthophosphoric acid) in the ratio of 50:50 % v/v at 1 ml/min flow rate and detection was carried out at 210 nm. The method was validated by determining system specificity, selectivity, suitability, linearity, precision, accuracy, robustness, and LOQ-LOD as per ICH Q2 (R1) guidelines. The developed method was found to be suitable for the routine quantitative analysis of Ipratropium bromide and Mometasone furoate in bulk and pharmaceutical dosage forms. It was also concluded that the developed method was accurate, precise, linear, reproducible, robust, and sensitive
In-silico ANALYSIS OF N-PHENYL PYRAZOLINE DERIVATES AS POTENTIAL OF HUMAN EPIDERMAL GROWTH RECEPTOR-2 (HER-2) INHIBITOR USING MOLECULAR DOCKING AND MD SIMULATIONS
Authors: D. Satria  , Waruwu S.B. , Sholikhah E.N. , Mustofa  , Satriyo P.B. , Wahyuningsih T.D. , Wiraswati H.L. , E. Damayanti
Published: May 2024

One of the most typical cancers to affect women worldwide is breast cancer. Multiple routes involving different proteins that control the development of cancer. HER-2 is a protein that contributes to the progression of breast cancer cells. This study uses n-phenyl pyrazoline derivate compounds. The predictive binding of several forms of pyrazoline compounds to HER-2 was analyzed using docking analysis in an in silico model. Pyrazoline A, B, C, D, and M were used as ligands, and neratinib as a commercial drug. Pyrazoline C was the ligand with the highest affinity (-109.218 Kcal/mol) if compared with native ligand 03Q (-170.697 Kcal/mol) and neratinib (-83.416 Kcal/mol). Pyrazoline C has the potential to develop as a breast cancer drug with COX-2 inhibitory activity. The molecular dynamics simulation for 50 ns showed that RMSD, RMSF, and SASA are rigid and stable. Pyrazoline C has the potential to develop as a breast cancer drug with HER-2 inhibitory activity.
ЕНЕРГЕТИЧНА БЕЗПЕКА УКРАЇНИ: ДРУГИЙ РІК ВІЙНИ
Authors: ЛІСОВИЙ Андрій
Published: May 2024

У статті розглядається питання енергетичної безпеки України в контексті сучасного світового енергетичного ландшафту. Зазначається, що Україна стикається з численними викликами, такими як залежність від імпортних ресурсів, технологічна відсталість, низька енергоефективність, і потенційні загрози з боку країни агресора. Автор у статті розглядає комплекс факторів від яких залежить стабільність та надійність енергетичного сектору країни. Стаття пропонує аналіз сучасного стану енергетичної безпеки, виявлення ключових викликів та пропонує шляхи їхнього вирішення. Зокрема, розглядаються стратегії диверсифікації постачання, розвиток внутрішніх ресурсів та сприяння енергоефективності. Автор вказує, що енергетична безпека України залежить від таких факторів, як геополітичне положення, наявність енергетичних ресурсів, інфраструктура та технології, енергоефективність та залежність від імпортних постачальників. Розуміння цих факторів допомагає визначити потенційні загрози та розробити стратегії забезпечення енергетичної безпеки України.
У статті автор акцентує увагу на важливості енергетичної безпеки для стабільності та розвитку країни і пропонує конкретні рекомендації для політичних, економічних та соціальних діячів для поліпшення ситуації у цій сфері. Зазначено, що Україна має значний потенціал у виробництві різних видів енергетичних ресурсів, які визначають її енергетичну самодостатність та впливають на енергетичну безпеку. Основними внутрішніми енергетичними ресурсами України є електроенергія, ядерна та теплова енергетика, а також відновлювані джерела енергії. У статті наводяться факти руйнації інфраструктури енергетичного сектору країни в наслідок російсько-української війни. Автор виділяє роль відновлюваних джерел енергії, які є важливим чинником для зменшення залежності від імпорту та зменшення викидів парникових газів. Однак, ворожі атаки також пошкодили або знищили багато об'єктів відновлюваної енергетики. У статті наводиться автором докладна інформація про стан електроенергетики, теплової енергетики, відновлюваних джерел енергії та інфраструктури електропередачі України під час воєнних дій. Висвітлюються потужність та стан різних об'єктів, а також збитки, завдані ворогом. З цього виникає розуміння сучасного стану енергетичної безпеки України та викликів, з якими країна стикається під час воєнних дій.
Bioactive Compounds of the Ethanol Extract of Butterfly Pea Petals (Clitorea ternatea L.) on Gastric Proton Pump: In-Silico Analysis
Authors: Kurniawati Atik , Lestari Sri Rahayu , Rohman Fatchur
Published: May 2024

Biodiversity of medicinal plants in Indonesia reflects the potential to be used to treat non-communicable diseases such as cancer. Gastritis is a kind of symptom felt in the stomach which may trigger severe abnormalities leading to a state of cancer. This study aims to determine the potential of bioactive compounds derived from the ethanol extract of butterfly pea petals (Clitoria ternatea L.) as an in-silico anti gastritis drug candidate. This was a descriptive study with a qualitative approach. The molecular docking method applied specific docking using PLANTS software. The results of molecular docking indicated that there might be similar potential as the control drug in inhibiting the gastric proton pump. Based on the analysis of the LCHRMS results, it was found flavonoid compounds in the extract of butterfly pea petals used for docking analysis. Each flavonoid compound and the docking score from highest to lowest were Rutin (-87.05), Quercetin-3β-D-glucoside (-79.30), Quercetin (-79.28), Kaempferol (-74.80), Trifolin (-74.22), Genistein (-69.70), Kaempferol-3-glucoside-3''rhamnoside (-67.79), Biochanin A(1−) (-67.64), and Mauritianin (-58.26). The flavonoid compound named rutin had the highest docking score above the two control drugs of Omeprazole (-66.27) and Vonoprazan (-84.45). It can be concluded that based on in-silico study, the flavonoid compound of Rutin in the ethanol extract of butterfly pea petals (Clitoria ternatea L.) had the potential to inhibit the gastric proton pump to prevent gastritis. The chemical structure of Rutin differs from the two control drugs because it has a more complex structure consisting of five benzene rings. It is recommended to carry out further dynamic molecular test to find out which flavonoid compounds are the most stable affinity for the target protein. Based on the in-silico test, in vivo and in vitro study should be performed to find out more information about the potential of the flavonoid compounds in butterfly pea extract in inhibiting the action of the gastric proton pump.
The Role of the Family in Preventing the Transmission of COVID-19 in Children
Authors: Onggang Fransiskus Salesius , Romana Aben B.Y.H. , Batbual Bringiwatty
Published: May 2024

COVID-19 is a disease that is highly communicable from infected individuals to others who are susceptible to infection. The family is the first line of defense against the spread of the COVID-19 epidemic among youngsters. There is transmission of the COVID-19 virus to children notwithstanding the inadequacy of parental efforts to prevent such transmission. The effect of COVID-19 infection on unfit parents will result in the transmission of the virus to offspring. The incidence of COVID-19 in children is influenced by the level of parental knowledge and conduct to avoid the transfer of the virus. The purpose of this study is to examine the relationship between parents' activities and attitudes regarding COVID-19 prevention, the detection of COVID-19 symptoms in children, and the level of information regarding the prevalence of COVID-19 in children. The research design employs a cross-sectional observational analysis. This study's demographic and sample consisted of proportional samples from 12 Community Health Centers, with 550 family respondents in total. The results of this study indicate that delivering the COVID-19 vaccination to the family considerably reduces the risk of COVID-19 transmission to children. The level of family knowledge correlates strongly with the transmission of COVID-19 to children (a symp=0.001, with a correlation p-value of 0.669). There is a correlation between the administration of the COVID-19 vaccine to parents and the transmission of the virus to children (symp=0.001, p=0.660). Based on the results of the study, there was a significant influence between the level of parental knowledge on the behavior of preventing COVID-19 in children in Kupang City. In addition, there is a significant relationship between the behavior and attitudes of parents who are disobedient in preventing COVID-19 in children and the incidence of COVID-19 in children. Families or parents who carry out the COVID-19 vaccination in the family also have a significant relationship with the transmission of the COVID-19 virus to children. To reduce the transmission of COVID-19 to children, efforts from the family are needed, such as implementing health protocols and carrying out vaccinations.
The Impact of Mental Health on the Job Performance of Medical and Non-Medical Workers
Authors: Abdullah Rabiya , Suryoputro Antono , Adi Mateus Sakundarno
Published: May 2024

In terms of their impact on the workforce, mental disorders in the workplace are a major concern. Poor mental health and stress can have a negative impact on worker performance and productivity, job attachment, collegial communication, physical performance, and daily functioning. The objective of this study is to investigate the relationship between mental health and job performance in medical and non-medical workers at general region hospital X. A quantitative cross-sectional study was conducted on 222 respondents, two of whom were medical and two of whom were non-medical workers, using a DASS-21 questionnaire and a job performance questionnaire. The findings show a relationship between age and job performance among medical and non-medical employees at General Region Hospital X. There is no significant relationship between mental health and job performance among medical workers. Gender, age, employment status, and work period all had a significant relationship with non-medical workers' job performance. Anxiety, gender, and age all have a significant relationship in non-medical workers. The conclusions is 44.1% reported poor job performance, 14.5% reported depression, 30.7% reported anxiety, and 11.3% reported stress. In both medical and non-medical workers, there was a significant interaction between anxiety and gender on job performance. Anxiety, gender, and age all had an impact on non-medical workers' job performance. It is critical to develop new health policies to prevent and treat mental health issues while also improving job performance. intervene and assist workers suffering from mental illnesses. Training and management on mental health, a conducive workplace, and social support can enhance productivity and decrease mental problems.
Maternal Parity, History of Obesity and History of Maternal GDM Risk a Macrosomia Baby
Authors: Martanti Listyaning Eko , Octaviani Dhita Aulia , Amelia Rizky , Suparmi Suparmi , Khobibah Khobibah
Published: May 2024

Gestational diabetes mellitus (GDM) is a carbide tolerance disorder that occurs or is first recognized during pregnancy (usually at 24 weeks gestation). For some patients, this complication returns to normal after delivery. The incidence of macrosomic infants or infants weighing >4000 grams is approximately 5% of all births. Maternal GDM is a significant risk factor in the development of fetal macrosomia. This study aimed to determine the risk factors for macrosomia in newborns. The design of this research is cross-sectional design. The population of this study was macrosomic babies born at Dr. Kariadi Semarang from 2015 until 2021. The formula for estimating the sample size using a hypothesis on the mean of two independent populations obtained a total sample of 60 respondents. The sampling technique is convenience sampling. The type of data used is secondary data. This study was analyzed using the Chi-Square test. The results indicated a relationship between parity and a history of obesity and macrosomia incidence in infants with a p-value < 0.05. In contrast, there was no relationship between maternal age, gestational age, and a history of diabetes in the mother and the incidence of macrosomia in infants with a p-value > 0.05. Therefore, it is essential to educate the mother about the risk factors that can cause complications for both the mother and the fetus, including macrosomia.
Factors Affecting Willingness to Pay for National Health Insurance Program among Informal Workers in Indonesia
Authors: Aji Budi , Masfiah Siti , Harwanti Siti , Ulfah Nur
Published: May 2024

The effort to achieve universal health coverage for all people under a single-payer national health insurance in Indonesia still experiences a substantial challenge particularly related to informal workers. This population faces a number of challenges, including income irregularity, a lack of educational variety, the fact that the majority of workers live in rural areas, and a lack of health insurance literacy. The objective of this study was to examine the factors that influence informal workers' willingness to pay for a national health insurance program in Indonesia. This cross-sectional study was conducted in the Banyumas district of Central Java, Indonesia. Employing a multistage random sampling technique, 316 workers in the informal sector were recruited as study participants. Logistic regression was employed to investigate the factors that influence willingness to pay for national health insurance premiums. According to the study findings, urban, national health insurance information, and uneducated factors were related to informal workers' willingness to pay for national health insurance. Workers who lived in urban area (p < 0.05, OR = 3.922) were more willing to pay for insurance premium. Workers who received better exposure of national health insurance information (p < 0.05, OR = 2.330) were more willing to pay for premium. Furthermore, workers who uneducated (p < 0.05, OR = 14.847) were more willing to pay for premium. The national health insurance campaign serves as a catalyst for increasing public awareness of this program. Adequate and widespread national health insurance program information dissemination would aid in the effectiveness of Indonesia's efforts to achieve the goal of universal health insurance coverage.
In Silico Analysis of the NPC1L1 Inhibitor of Catechins from Green Tea
Authors: Susanti Erna , Setyadini Ellyvına
Published: May 2024

The main contributor to cardiovascular disease is atherosclerosis. The Liver X Receptor is one of the unexplored signaling pathways in atherosclerosis that contributes to cholesterol efflux and inhibitory inflammation (LXR). Catechin, as an LXR agonist, influences the expression of the NPC1L1 protein transporter, which inhibits cholesterol absorption. The objective of this study is to predict the NPC1L1 inhibitor of Catechins from Green Tea. The role of NPC1L1 inhibitors is to prevent atherogenesis. Molecular docking is the research method used. Pyrx's Open Babel was used for analysis. Autodock vina in Pyrx was employed for docking, and Chimera v1.8 was administered for visualization. The result of molecular interaction was assigned. Pose view was used in this study. Catechins have the potential to be an NPC1L1 inhibitor, according to the findings. The main parameters used to predict the biological effect were energy bonds, hydrogen bonds, and hydrophobic interactions of molecules with NPC1L1. All Catechins isolates had low affinity energy and a strong affinity for NPC1L1. Epigallocatechin gallate (EGCG) is the most effective inhibitor because it has the lowest binding energy and the most active sites, including Gln 200, Tyr 192, Trp 202, Cys 189, Gly 207, Asp 217, Gly 190, Phe 205, Asp 208. There are hydrogen bonds at Thr 219, Ile 218, Asn 204, Asn 211, Arg 201, and Asn 204. The interaction energy between NPC1L1 and EGCG is -7.5 kCal/mol. Based on the results of the in-silico analysis, the researchers concluded that Catechins have the potential to be an NPC1L1 inhibitor. Further research into molecular dynamic simulation and in vivo analysis is required to demonstrate the synergistic effect of Catechins as an inhibitor of atherogenesis.
Effect of Soybean Juice on the Increase in Hemoglobin Levels among Adolescent Girls
Authors: Olii Nancy , Salman Salman , Ischak Wenny Ino , Manueke Iyam , Donsu Amelia , Nurdin Siti Surya Indah , Abdul Nurnaningsih Ali
Published: May 2024

The highest percentage of anemia occurs among adolescent girls, and one of the efforts to overcome such problem is iron supplementation along with iron-rich foods from animal sources such as red meat and marine products, as well as vegetable sources such as nuts. Soybean is a kind of iron-rich food which contains 8.0/100 g of iron. This study aims to observe the increase in hemoglobin levels after the administration of soybean juice among adolescent girls. This was a pre-experimental study with a one group pretest-posttest design. The populations consisted of 133 adolescent girls of VII and VIII graders with a sample size of 35 respondents who were selected by using purposive sampling technique. The respondents were given 250 ml of soybean juice for 21 consecutive days every morning. On the twenty-second day, the Hb levels of respondents were re-assessed (post-test). The blood sample taken was a capillary blood at the fingertip. The statistical test applied the Paired T-Test. The results revealed that hemoglobin levels of respondents who were given soybean juice increased by 12.06 g/dl with a difference of 1.62 g/dl. This study concluded that 250 ml soybean juice had an effect on the hemoglobin levels among adolescent girls. Adolescents are recommended to regularly consume iron-rich foods and beverages with various kinds of preparations such as soybean juice.
Apgar Score and the Amount of Blood of Mother in Labour in Delayed Cord Clamping Period
Authors: Marlina Marlina , Trianingsih Indah , Sari Adinda Juwita , Rosmadewi Rosmadewi
Published: May 2024

A delay in cutting the umbilical cord in infants can increase the Apgar score in infants who experience asphyxia. Besides that, it can prevent postpartum hemorrhage from occurring. Most deaths from postpartum hemorrhage occur during the first 24 hours after delivery. This increase in the Apgar value proves that the longer the delay in the umbilical cord is carried out, even until it doesn't pulsate, the better the baby's body will be, which results in an increase in hemoglobin in the baby's body. The population in this study were all mothers in the 3-4 stage of labor in the city area. Bandar Lampung. The sample is part of the number and characteristics possessed by the population with 120 maternal. It is known the length of time delayed cord Clamping is performed on babies born (<30 seconds) as many as 3 (2.5%) respondents, while umbilical cord clamping is delayed for 30-180 seconds as many as 117 (97.5%) respondents, the Apgar score in newborns in the category of mild asphyxia - not asphyxia as much as 100%, the amount of blood that came out <250 grams was 93 (77.5% ) respondents and the amount of blood that came out 250 grams were 27 (22.5%) respondents. Delayed cord clamping does not increase the incidence of asphyxia and bleeding in laboring mothers, so immediate umbilical cord clamping can be performed by observing the baby's birth condition.
The Influence of Service Quality on BPJS Health Patient Satisfaction in the Outpatient Unit at Mitra Siaga Hospital, Tegal
Authors: Dahlan Muslih , Widjanarko Bagoes , Jati Sutopo Patria
Published: May 2024

Good health services provide services that are effective, safe, and of high quality.  Efforts that have been made by the management of Tegal MS Hospital in maintaining and improving the quality of service, namely by holding training and simulation of excellent service, socializing BPJS Health related to a tiered referral system, equipping medical and non-medical equipment, repairing infrastructure, and carrying out standardization according to accreditation guideline assessments.  This research was conducted to determine the effect of service quality on BPJS Health patient satisfaction in the outpatient unit of Tegal MS Hospital. This type of research is observational research with a quantitative approach. The population in this study were BPJS Kesehatan patients in the outpatient unit of Tegal MS Hospital who met the inclusion criteria of this study. Based on calculations with the Slovin formula above, a research sample of 99.9 was obtained, and the results were rounded up to 100 respondents. Data analyzed use univariate analysis, bivariate analysis, and multivariate analysis. The infrastructure variable positively and significantly influences patient satisfaction with a p- value of 0.026 <0.05. Research results from Infrastructure variable, variable Personnel Quality, Clinical Care Process Variables, Administrative Procedure Variables, Variables Patient Safety Indicator, Hospital Image Variable, Social Responsibility Variable, Trust Variable to House Sick has a positive and significant effect on patient satisfaction variables with the results of p- values each variable < 0.05. To examine patient satisfaction, apart from using service quality as the dependent variable, future researchers are also expected to be able to add other dependent variables such as hospital cost factors, patient emotional factors, or family economic conditions and even other variables that might affect the level of patient satisfaction.
Development of Local Foodstuff-Based Complementary Food Porridge MP-ASI "SITOLE" Products as an Effort to Manage Stunting
Authors: Waryana Waryana , Wijanarka Agus , Fadhilah Dina
Published: May 2024

One of the causes of stunting is poor nutritional intake in infancy and recurrent illnesses due to an unhealthy environment. Mothers of under-five children are the potential strategic target to be empowered to manage stunting. They have to be empowered to meet nutritional needs during infancy. Complementary breast milk food containing calcium, zinc, selenium, iodine, Fe, protein, and phosphorus can be developed using local foodstuffs. This study aimed to investigate the impact of community empowerment training on the knowledge improvement of mothers regarding the development of locally sourced complementary feeding products (MP-ASI) as an intervention to address stunting issues and to formulate a nutrient-rich complementary food product for infants aged 6-12 months. The research design employed was a quasi-experimental study with a pre-and post-test with a control group design. The study subjects were mothers with infants aged 6-12 months residing in Triharjo Village, Kapanewon Pandak, who met the inclusion criteria and were willing to participate. Mothers who were unable to read and write were excluded from the study. The study was conducted in Triharjo Village, Kapanewon Pandak, Bantul, from April to July 2022. A total of 54 respondents, selected through simple random sampling, were included as the study sample out of 100 families population. Knowledge data were collected using a questionnaire as the data collection instrument and analyzed using the Dependent T-Test and Independent T-Test at a 95% confidence level. The results indicated a significant difference in knowledge improvement (delta) between the treatment and control groups. A locally sourced complementary food product for infants aged 6-12 months, named "SITOLE" porridge, was developed as an outcome. The development data of the MP-ASI product (Sitole porridge) were compiled using a group discussion method.
The Effectiveness of Web-Based E-WoHealth on Compliance with Consumption of Iron Tablets in Young Women
Authors: Yulianti Desak Made , Ahmad Mardiana , Baso Yusring Sanusi , Sinrang Andi Wardihan , Usman Andi Nilawati , Prihantono Prihantono
Published: May 2024

Utilization of technological media in the field of education and health can increase public knowledge in efforts to prevent anemia, especially in young women. One of the efforts to prevent anemia and increase adherence to taking iron tablets is by using Web-based educational media (E-WoHealth) about iron tablets supplemented with a tablet supplement consumption control card. This research aims to develop Web-based E-WoHealth media and its effect on the level of adherence to the consumption of blood supplement tablets. This study used the Research and development (R&D) method with the Borg & Gall development model and the Pre-experimental Design quantitative method using the One Group Pretest-Postest approach. The sample in this study was 80 girls in grades VII and VIII of SMP Negeri 11 Gorontalo City, determined by purposive sampling technique. Statistical tests used the McNemar test and the Chi-Square test. The results of the McNemar test showed differences in the measurement results before and after being given the Web-based E-WoHealth media with a p-value of 0.000 <0.05 meaning that the Web-based E-WoHealth media was effective in increasing adherence to consumption of iron supplement tablets (TTD) in class VII and class VIII girls and the results of the Chi-Square P-Value test were 0.822 > 0.05 meaning that there was no difference in adherence between class VII and VII girls. This study recommends the application of WEB-based E-WoHealth media equipped with an iron supplement control card to increase adherence and monitor iron supplement consumption.