bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional, textural, and sensory quality of bars enriched with banana flour and pumpkin seed flour
Authors: Habiba Umme , Robin Md. Ashadujjaman , Hasan Md. Mehedi , Toma Maria Afroz , Akhter Delara , Mazumder Md. Anisur Rahman
Published: July 2021

Introduction. Nowadays, health-conscious consumers attend to nutritional, health, and easy-to-use products. Demand for healthy snacks is significantly increasing. Our study aimed to develop high protein nutrition bars by incorporating pumpkin seed flour and banana flour and assess their quality.

Study objects and methods. We analyzed three bar samples for nutritional, textural, and sensory quality. The bars contained banana flour, pumpkin seed flour, and the mixed flour. Proximate analysis was performed following the AOAC method. The mineral content and antioxidant properties of the bars were determined by using emission spectrophotometry and the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging modified method, respectively.

Results and discussion. The mixed flour nutrition bar had significantly higher total phenolic content and antioxidant activity than the bar with banana flour and the bar with pumpkin seed flour. Textural analysis demonstrated that the mixed flour sample had significantly (P < 0.05) higher hardness and color parameters compared to the other bar samples. Nutritional analysis indicated that mixed flour bar contained significantly higher amounts of protein, fat, and calcium; while pumpkin seed flour bar had higher ash, iron, and magnesium contents. The mixed flour sample also had better sensory parameters.

Conclusion. The mixed flour demonstrated good quality. Hence, both banana and pumpkin seed flour have a potential to be used in bar formulations.
Pedagogical Model of Health-Preserving and Adaptive Potential in Class Environment
Authors: Arlasheva Lyudmila , Kazin Eduard , Kasatkina Natalia
Published: July 2021

he concept of life-long education and the Federal State Educational Standard for General Education presupposes teaching technologies that form a positive attitude to a safe and healthy lifestyle in teenagers. The cognitive and social tasks that teenagers have to face grow more and more complex, which means that class environment should develop their coping potential and healthy lifestyle habits. The article features a pedagogical model for improving the health-saving and coping potential of adolescents in class. The model includes functional components that consist of organizational and pedagogical conditions aimed at solving learning, developmental, educational, and social tasks in class and during extracurricular activities. Monitoring proved to be the main organizational and pedagogical condition for improving the potential of adolescents in adaptation and healthy lifestyle habits. Monitoring includes three main stages: analytical, technological, and corrective. The research involved traditional and modified criteria of the health-saving and coping potential. The experiment proved the effectiveness of the new model.
Intellectual Abilities of Younger Adolescents with Different Levels of Stress Resistance
Authors: Kagan Elena , Tupikina Galina , Tsigichko Elena
Published: July 2021

The research featured the intellectual abilities of teenagers with different levels of stress resistance. The research objective was to describe the options for intellectual development of secondary school students depending on their stress resistance level. The authors reviewed various approaches to intellectual development of younger adolescents. They proposed a set of assessment techniques for the level of mental development. The research revealed the effect of stress resistance on the intellectual abilities of teenagers. Teenagers with a low level of stress resistance were excitable and careless, while demonstrating tender conscience and poor analytical and verbal skills. Respondents with a high level of stress showed a low level of excitability and conscientiousness, a high level of carelessness, a good ability to establish analogies, and admirable verbal abilities. The paper contains some useful recommendations for teachers and parents on the development of teenagers' intellectual skills based on their level of stress resistance.
Foreign Experience of Legal Support for the Protection of Honor, Dignity, and Business Reputation
Authors: Abakumova Ekaterina , Komissarov Alexey , Tarasov Dmitrii
Published: July 2021

The article examines the concept and development of legal relations in the field of the protection of honor, dignity, and business reputation in foreign legislation, where they are part of the legal institution of defamation. The research involved the formal-legal and comparative-legal techniques based on the principles of historicism and objectivity. The article features a retrospective summary of theoretical, normative, and practical approaches to the conceptual application of the institute of defamation in the countries of the Anglo-Saxon and continental law. The Anglo-American defamation law is formed both within the general and statutory framework. Special legislative acts of the United Kingdom define the conditions (criteria) for classifying these legal relations as essentially defamatory. The peculiarities of the continental defamation law can be attributed to its mainly criminal-legal regulatory component, rather than civil or administrative law. The comparative legal review of the foreign experience of legal support for the protection of honor, dignity, and business reputation proved relevant and practically significant.
Inheriting the Property of an Individual Entrepreneur
Authors: Filippova Tat'yana
Published: July 2021

The last will issues are always relevant, since they are associated with the desire and ability of a citizen to provide financially for their heirs. The current legislation takes into account the will of the testator and reflects, to some extent, the changes that occur in society. The present article features the current inheritance law of the Russian Federation, which, as it appears, do not reflect the special legal status of an individual entrepreneur. The authors analyzed statistical data confirming the place of individual entrepreneurs in the modern economy. The legislation on inheritance underestimates this fact, which leads to a violation of people’s rights and negative consequences in the business sphere. The research objective was to consider the issues of inheritance after the death of an individual entrepreneur, taking into account the preservation of the business, the stability of civil circulation, and the interests of the testator. The authors examined the existing approaches to the legal status of an individual entrepreneur and various cases of controversial conclusion about the property inheritance. They also assessed the effectiveness of legal regulation of inheriting the property of an individual entrepreneur and developed options for preserving the business, including a trust management agreement for inherited property. However, the notarial practice in this regard remains quite inconsistent. The paper contains several proposals for improving the current inheritance law.
Niat Pembelian Kembali pada aplikasi dan/atau situs Online Travel Agency (OTA)
Authors:   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Ikegami Daichi , Mardhi Lukas ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Roro Diah Wulansari Raden ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Febriana Erawati Ratu ,   School of Business and Economics Universitas Prasetiya Mulya JL. RA. Kartini (TB Simatupang), Cilandak Barat Jakarta Selatan, Jakarta 12430 Indonesia., Respati Ricko ,   School of Business and Economics, Universitas Prasetiya Mulya, Cilandak Campus, Jl. RA. Kartini (TB Simatupang), Cilandak Barat, Jakarta Selatan 12430
Published: July 2021

Tujuan dari penelitian ini adalah untuk menjelaskan, menggambarkan, menganalisa dan melakukan pengujian efek atau dampak dari faktor-faktor pengalaman pelanggan terhadap niat pembelian kembali pada media aplikasi dan/atau situs Online Travel Agency (OTA) dengan kepuasan pelanggan sebagai variabel penghubung. Kerangka konseptual dibentuk berdasarkan tinjauan literatur dari penelititan sebelumnya. Metode kuantitatif dilakukan dengan melakukan penyebaran daftar pertanyaan (survey) dan didistribusikan ke sampel responden yang berada di wilayah Jakarta, Indonesia, berusia produktif (21 tahun keatas) yang terdiri dari mahasiswa, karyawan, dan pengusaha sebagai pengguna aplikasi dan/atau situs Online Travel Agency (OTA). Analisis regresi digunakan untuk menganalisis data. Terdapat 8 faktor pengalaman pelanggan dalam melakukan transaksi e-commerce di aplikasi dan/atau situs Online Travel Agency (OTA) (Kemudahan penggunaan, Interaksi, Keamanan, Keandalan Pemenuhan, Pelayanan pelanggan, Penawaran toko, Manfaat Pelanggan/Persepsi Nilai, dan Proses pembelian yang jelas). Penelitian menunjukan bahwa faktor proses pembelian yang jelas memegang peranan penting dalam mempengaruhi kepuasan pelanggan dalam bertransaksi menggunakan aplikasi dan/atau situs Online Travel Agency (OTA) yang pada akhirnya memberikan dampak niat untuk melakukan pembelian kembali dimasa yang akan datang.
The experience of using the mobile phone data in economic geographical researches in foreign
Authors:   Plekhanov Russian University of Economics, Babkin Roman A.
Published: July 2021

The era of "Big data" and the emergence of new sources of geo-information, including mobile phone data, have provided fundamentally new opportunities for research on many socio-economic processes. Compared to traditional statistical sources, mobile phone data has many unique features and advantages that attract scientists from various fields of knowledge. Extensive experience in the use of technologies for collecting and processing spatial information from mobile phones over the past 15 years has led to interest in them in order to improve demographic statistics, transport planning, analysis of settlement systems, tourism statistics, study of human behavior and emergency monitoring. The article demonstrates various cases of using mobile operator data in scientific and applied research in these areas using examples of foreign works. Foreign practice of using data from mobile operators demonstrates how data analysis can complement the results of censuses and population registers, allowing you to move from static to dynamic consideration of the settlement system. The combination of mobile telephony data with traditional statistics, as well as other types of "Big data", such as remote sensing, helps to improve the spatial and temporal resolution of geo-information in the study of demographic and socio-economic processes. At the same time, it can be observed that the potential use of this data source is not limited to supplementing the system of existing statistical indicators, but includes the creation of new socio-economic indicators. At the same time, the long-standing problem of national statistics lagging behind the leading countries of Europe and the United States can be largely offset by the incorporation of "Big data" into research practice.
Mismanaged space: planning and policymaking in the context of depopulation in Ivanovskaya oblast
Authors:   Politecnico di Milano, Department of Architecture and Urban Studies, Batunova Elena Yu. , Gunko Maria S. ,   Institute of Geography Russian Academy of Sciences, Department of Socio-economic geography, Medvedev Andrey A. ,   Institute of Geography Russian Academy of Sciences, Laboratory of Cartography
Published: July 2021

Since the second half of the twentieth century, cities and regions worldwide have experienced depopulation due to the global economic and social transformation. Aging and natural population decline have become characteristic for Russia already in the late-Soviet period. In addition, the transition from state socialism to neoliberal capitalism with a change in rationality of economic development and governance has led to an intensification of internal migration flows. Against this background, the aim of the current lies in a comparative analysis of the main trends in the transformation of the regional settlement system and the response to these transformations proposed by the regional and municipal planning and policy in Russia. The research is carried out based on the example of Ivanovskaya oblast. By analyzing statistical and remote sensing data, the study highlights the general negative demographic trends in the region, intra-regional differences in these trends, as well as the results of their impact on the transformation of the settlement pattern. Content analysis of normative documents allows revealing features of official policymaking and planning agenda at regional and municipal levels, which determine territorial development in the context of depopulation. Based on the results of the content analysis, the following conclusions are drawn. First, there seem to be an incomplete or simplified understanding of dynamics, causes, and consequences of depopulation both at the regional and municipal levels. Second, coordination between different levels of governance in managing depopulation appears to be insufficient. Third, regional authorities do not seem to “accept” the current demographic situation as the basic condition for forming long-term scenario of the region’s development.
A case of false-positive diagnosis of skin melanoma in a child
Authors: Belysheva T. S. , Vishnevskaya Ya. V. , Volkova A. S. , Valiev T. T. , Mikhailova S. N. , Polyakov V. G.
Published: July 2021

Diagnosis of skin melanoma (SM) in children is a complex clinical and morphoimmunological problem. The rare occurrence, difficult interpretation of histological and immunohistochemical picture explain the error rate in the diagnosis of SM reaching 28.8 %. This article presents a clinical case of false-positive diagnosis of SM. As a result of a detailed assessment of the anamnesis, examination, revision of histological preparations and conducting an immunohistochemical study in the reference center, the diagnosis of SM was excluded.
Resolution of the Expert council on the problems of diagnosis and treatment of patients with plexiform neurofibromas
Authors: Editorial Article
Published: July 2021

Плексиформная нейрофиброма (ПНФ) — доброкачественная опухоль периферической нервной системы.
Traumatic Hip Dislocation: Lecture
Authors: Berezin P. A. , Bragina S. V. , Petrushin A. L.
Published: July 2021

Traumatic hip dislocations occupy the fourth place among dislocations of various localizations and, as a rule, are the result of  exposure  to  a  high-energy  traumatic  agent.  Such  injuries  are  more  often  observed  in  young  and  middle-aged  males. The main cause of hip dislocations is road accidents. The femoral head is more often dislocated posteriorly, but anterior dislocations  are  not  casuistic  and  account  for  approximately  10%.  Hip  dislocations  are  often  combined  with  acetabular fractures,  while  their  fairly  clear  clinical  picture  in  the  presence  of  fractures  can  be  leveled.  Traumatic  hip  dislocations require urgent diagnosis and treatment. After the clinical examination of the patient, an x-ray of the pelvis and hip joints are performed. Radiographic diagnosis of hip dislocation remains relevant, but modern imaging methods allows to study the hip joint in more detail and identify concomitant injuries. The main treatment for hip dislocation is closed reduction. Early dislocation reduction and the absence of damage to the structures forming the hip joint are important for the treatment results prognosis. The further patient management tactics after the dislocation reduction is determined by the results of stress tests and the CT data. When confirming the instability and associated injuries of the hip joint anatomical structures, surgical treatment is indicated. Among the complications of hip dislocation: sciatic nerve damage, post-traumatic coxarthrosis, the femoral head avascular necrosis, heterotopic ossification. Current literature data indicates the importance of early diagnosis of dislocation-associated injuries of the hip joint and periarticular tissues. Early and comprehensive repair of all existing injuries is crucial for favorable outcomes. A number of therapeutic and diagnostic methods, primarily arthroscopy, show optimistic results, but need further study.
Histological evaluation of periprosthetic infection using HOES scale and CD15 expression analysis at the stage of the hip revision arthroplasty
Authors: Silanteva T. A. , Ermakov A. M. , Tryapichnikov A. S.
Published: July 2021

Background.The effectiveness improvement and standardization of the methods of histological diagnosing periprosthetic infection (PPI) is an urgent task in the treatment of complications after large joint arthroplasty. Purpose of the study— Histopathological evaluation of the infection involvement of periprosthetic tissues at the stage of revision arthroplasty for deep infection of the hip using HOES scale and immunohistochemical analysis of CD15 expression.Materials and Methods.A single-center prospective study was performed on the clinical intraoperative material obtained at the stage of revision arthroplasty of the hip in 27 patients at the age of 65 (55÷69) years. The group of examination included patients with acute and chronic forms of deep periprosthetic infection. Light-optical microscopic investigation of the samples of periprosthetic connective-tissue membrane and bone tissue from the foci of infectious involvement was made on paraffin sections stained with hematoxylin and eosin; with the immunohistochemical reaction to determine the expression of CD15 neutrophil granulocyte markers. HOES Scale for pathohistological assessment was used in order to objectify osteomyelitis signs in periprosthetic bone tissue.Results. The signs of acute and chronic stages of periprosthetic osteomyelitis were observed in 9/16 patients with PPI chronic course within 1–30 months of postoperative period, from one to 18 months after manifestation of the symptoms. The signs of subsided osteomyelitis were determined in 12/27 patients with PPI of acute and chronic forms. Infected periprosthetic membranes were found in 19/27 clinical cases in the early and longterm  time  periods  after  arthroplasty  surgery.  A  direct  significant  correlation  was  revealed  between  histopathological signs  of  infecting  the  periprosthetic  bone  and  the  connective-tissue  periprosthetic  membrane,  especially  strong  one in  patients  with  acute  and  chronic  PPI  osteomyelitis.Conclusion. The  use  of  HOES  Scale  and  the  analysis  of  CD15 expression  ensure  the  objectivity  of  PPI  histological  diagnosing.  The  results  obtained  indicate  an  increased  risk  of osteomyelitis development in patients with chronic periprosthetic infection after the hip arthroplasty.
Young People’s Experiences of Engaging With Fitspiration on Instagram: Gendered Perspective
Authors: Mayoh Joanne , Jones Ian
Published: July 2021

Background

Fitness inspiration or fitspiration is a term used to describe web-based images of fit people, people in the gym, health foods, or inspirational quotes relating to diet and fitness being shared and consumed via visual social media. The popularity of this content is most notable via the Instagram platform. Currently, the majority of fitspiration research has focused on women’s experiences; however, increasingly, studies have pointed to the need to explore the gendered ways by which people engage with this content.

Objective

The aim of this study is to explore how young men and women engage in fitspiration content on Instagram and provide a gendered analysis of how and why they consume this content.

Methods

This study used a cross-sectional web-based survey (N=1213) of UK-based fitspiration users aged 18-24 years consisting of closed-ended questions to capture quantitative data.

Results

The majority actively using Instagram for fitspiration (therefore eligible participants) were women (826/1175, 70.30%). Men were more likely to view content posted by athletes (χ21, N=1153=71.8; P=.001) and bodybuilders (χ21, N=1153=32.8; P<.001), whereas women were more likely to view content related to weight loss (χ21, N=1153=36.8; P<.001), diet plans (χ21, N=1153=11.9; P<.001), and celebrities’ content (χ21, N=1153=33.5; P<.001). Men were more likely to use fitspiration as a source of inspiration to exercise to gain muscle or get stronger (χ21, N=1147=17.9; P<.001), whereas women were more likely to use fitspiration as inspiration for healthy eating (χ21, N=1147=37.7; P<.001), or to exercise to diet or lose weight (χ21, N=1147=13.5; P<.001). Women were more likely to engage in passive behaviors such as viewing content on their feed (χ21, N=1139=7.9; P=.005) or scrolling through accounts (χ21, N=1139=15.2; P<.001), whereas men were more likely to engage in active consumption by tagging fitspiration accounts in posts (χ21, N=1139=7.2; P=.007), commenting on posts (χ21, N=1139=8.1; P=.004), and posting fitspiration content (χ21, N=1139=6.4; P=.01).

Conclusions

Female fitspiration consumers engaged with content that reinforced the feminine thin but shapely ideal, whereas male users sought out content that reinforced the masculine muscular ideal. Male users were more likely to engage actively with content (eg, posting fitspiration content), while female users were more likely to engage passively (eg, scrolling through accounts, posts, or images). Future research should consider how fitspiration consumption reflects and reproduces oppressive gender ideology.
Designing Asynchronous Remote Support for Behavioral Activation in Teenagers With Depression: Formative Study
Authors: Bhattacharya Arpita , Nagar Ria , Jenness Jessica , Munson Sean A , Kientz Julie A
Published: July 2021

Background

Many teenagers in the United States experience challenges with symptoms of depression, and they lack adequate resources for accessing in-person mental health care. Involving teens and clinicians in designing technologies that use evidence-based practices that reduce barriers to accessing mental health care is crucial. Interventions based on behavioral activation (BA) help teens understand the relationship between mood and activity, help them practice goal-directed behaviors to improve mood, and may be particularly well-suited to delivery via internet-based platforms.

Objective

This study aims to understand the needs and challenges that teens and mental health clinicians face in depression management and involve them in the design process of a remote intervention that uses asynchronous remote communities. Our goal is to understand the benefits and challenges of adapting BA to an internet-based platform that supports the asynchronous remote community approach as a delivery tool for teen depression management.

Methods

We enrolled mental health clinicians (n=10) and teens (n=8) in separate, private, internet-based groups on Slack (Slack Technologies Inc). They participated in 20-minute design activities for 10 weeks and were then invited to interviews about their experiences in the study.

Results

Both teen and clinician participants wanted internet-based support for BA as a supplement to in-person therapy. Although participants perceived the asynchronous format as conducive to supporting accessible care, teens and clinicians raised concerns about safety, privacy, and the moderating of the internet-based group. Design decisions that address these concerns need to be balanced with the potential benefits of learning coping skills, increasing access to mental health care, and promoting asynchronous human connection to support teens.

Conclusions

We discuss considerations for balancing tensions in privacy and safety while designing and selecting internet-based platforms to support remote care and integrating evidence-based support when designing digital technologies for the treatment of teens with depression.
Search Behavior Regarding Cancer Susceptibility Genes Using a Clinical Decision Support Tool for Gene-Specific Penetrance: Content Analysis
Authors: Yin Kanhua , Zhou Jingan , Singh Preeti , Wang Jin , Braun Danielle , Hughes Kevin S
Published: July 2021

Background

Genetic testing for germline cancer susceptibility genes is widely available. The Ask2Me.org (All Syndromes Known to Man Evaluator) tool is a clinical decision support tool that provides evidence-based risk predictions for individuals with pathogenic variants in cancer susceptibility genes.

Objective

The aim of this study was to understand the search behavior of the Ask2Me.org tool users, identify the patterns of queries entered, and discuss how to further improve the tool.

Methods

We analyzed the Ask2Me.org user-generated queries collected between December 12, 2018, and October 8, 2019. The gene frequencies of the user-generated queries were compared with previously published panel testing data to assess the correspondence between usage and prevalence of pathogenic variants. The frequencies of prior cancer in the user-generated queries were compared with the most recent US population–based cancer incidence.

Results

A total of 10,085 search queries were evaluated. The average age submitted in the queries was 48.8 (SD 16.5) years, and 84.1% (8478/10,085) of the submitted queries were for females. BRCA2 (1671/10,085, 16.6%), BRCA1 (1627/10,085, 16.1%), CHEK2 (994/10,085, 9.9%), ATM (662/10,085, 6.6%), and APC (492/10,085, 4.9%) were the top 5 genes searched by users. There was a strong linear correlation between genes queried by users and the frequency of pathogenic variants reported in published panel testing data (r=0.95, r2=0.90, P<.001). Over half of the queries (5343/10,085, 53.0%) included a prior personal history of cancer. The frequencies of prior cancers in the queries on females were strongly correlated with US cancer incidences (r=0.97, r2=0.95, P<.001), while the same correlation was weaker among the queries on males (r=0.69, r2=0.47, P=.02).

Conclusions

The patients entered in the Ask2Me.org tool are a representative cohort of patients with pathogenic variants in cancer susceptibility genes in the United States. While a majority of the queries were on breast cancer susceptibility genes, users also queried susceptibility genes with lower prevalence, which may represent a transformation from single gene testing to multigene panel testing. Owing to these changing tides, more efforts are needed to improve evidence-based clinical decision support tools to better aid clinicians and their practice.
Practitioners’ and Policymakers’ Successes, Challenges, Innovations, and Learning in Promoting Children’s Well-being During COVID-19: Protocol for a Multinational Smartphone App Survey
Authors: Davidson Jennifer C , Karadzhov Dimitar , Wilson Graham
Published: July 2021

Background

The advent of COVID-19 abruptly thrust the health and safety of children and families into greater risk around the world. As regional and local governments, nongovernmental organizations, communities, families, and children grapple with the immediate public health impact of COVID-19, the rights and well-being of children, especially those who are already marginalized, have been overlooked. Those working with children have likely encountered unprecedented challenges and responded in innovative ways in efforts to address the needs and rights of all children.

Objective

This paper presents a protocol for a large-scale, multinational study using a new smartphone app to capture the real-time experiences and perspectives of practitioners and policymakers supporting children and families during the COVID-19 pandemic around the globe in relation to a children’s human rights 4P framework of protection, provision, prevention, and participation.

Methods

This protocol describes a mixed methods survey utilizing a custom-built iOS and Android smartphone app called the COVID 4P Log for Children’s Wellbeing, which was developed in close consultation with 17 international key partner organizations. Practitioners and policymakers working with and for children’s well-being across 29 countries and 5 continents were invited to download the app and respond to questions over the course of 8 weeks. The anticipated large amount of qualitative and quantitative response data will be analyzed using content analysis, descriptive statistics, and word frequencies.

Results

Formal data collection took place from October 2020 until March 2021. Data analysis was completed in July 2021.

Conclusions

The findings will directly inform the understanding of the ways in which COVID-19 has impacted practitioners’, managers’, and policymakers’ efforts to support children’s well-being in their practices, services, and policies, respectively. Innovative and ambitious in its scope and use of smartphone technology, this project also aims to inform and inspire future multinational research using app-based methodologies—the demand for which is likely to continue to dramatically rise in the COVID-19 era. Mitigating the risks of longitudinal remote data collection will help maximize the acceptability of the app, respondents’ sustained engagement, and data quality.

International Registered Report Identifier (IRRID)

DERR1-10.2196/31013
Designing Asynchronous Remote Support for Behavioral Activation in Teenagers With Depression: Formative Study (Preprint)
Authors: Bhattacharya Arpita , Nagar Ria , Jenness Jessica , Munson Sean A , Kientz Julie A
Published: July 2021

BACKGROUND

Many teenagers in the United States experience challenges with symptoms of depression, and they lack adequate resources for accessing in-person mental health care. Involving teens and clinicians in designing technologies that use evidence-based practices that reduce barriers to accessing mental health care is crucial. Interventions based on behavioral activation (BA) help teens understand the relationship between mood and activity, help them practice goal-directed behaviors to improve mood, and may be particularly well-suited to delivery via internet-based platforms.

OBJECTIVE

This study aims to understand the needs and challenges that teens and mental health clinicians face in depression management and involve them in the design process of a remote intervention that uses asynchronous remote communities. Our goal is to understand the benefits and challenges of adapting BA to an internet-based platform that supports the asynchronous remote community approach as a delivery tool for teen depression management.

METHODS

We enrolled mental health clinicians (n=10) and teens (n=8) in separate, private, internet-based groups on Slack (Slack Technologies Inc). They participated in 20-minute design activities for 10 weeks and were then invited to interviews about their experiences in the study.

RESULTS

Both teen and clinician participants wanted internet-based support for BA as a supplement to in-person therapy. Although participants perceived the asynchronous format as conducive to supporting accessible care, teens and clinicians raised concerns about safety, privacy, and the moderating of the internet-based group. Design decisions that address these concerns need to be balanced with the potential benefits of learning coping skills, increasing access to mental health care, and promoting asynchronous human connection to support teens.

CONCLUSIONS

We discuss considerations for balancing tensions in privacy and safety while designing and selecting internet-based platforms to support remote care and integrating evidence-based support when designing digital technologies for the treatment of teens with depression.

CLINICALTRIAL
Search Behavior Regarding Cancer Susceptibility Genes Using a Clinical Decision Support Tool for Gene-Specific Penetrance: Content Analysis (Preprint)
Authors: Yin Kanhua , Zhou Jingan , Singh Preeti , Wang Jin , Braun Danielle , Hughes Kevin S
Published: July 2021

BACKGROUND

Genetic testing for germline cancer susceptibility genes is widely available. The Ask2Me.org (All Syndromes Known to Man Evaluator) tool is a clinical decision support tool that provides evidence-based risk predictions for individuals with pathogenic variants in cancer susceptibility genes.

OBJECTIVE

The aim of this study was to understand the search behavior of the Ask2Me.org tool users, identify the patterns of queries entered, and discuss how to further improve the tool.

METHODS

We analyzed the Ask2Me.org user-generated queries collected between December 12, 2018, and October 8, 2019. The gene frequencies of the user-generated queries were compared with previously published panel testing data to assess the correspondence between usage and prevalence of pathogenic variants. The frequencies of prior cancer in the user-generated queries were compared with the most recent US population–based cancer incidence.

RESULTS

A total of 10,085 search queries were evaluated. The average age submitted in the queries was 48.8 (SD 16.5) years, and 84.1% (8478/10,085) of the submitted queries were for females. BRCA2 (1671/10,085, 16.6%), BRCA1 (1627/10,085, 16.1%), CHEK2 (994/10,085, 9.9%), ATM (662/10,085, 6.6%), and APC (492/10,085, 4.9%) were the top 5 genes searched by users. There was a strong linear correlation between genes queried by users and the frequency of pathogenic variants reported in published panel testing data (r=0.95, r2=0.90, P<.001). Over half of the queries (5343/10,085, 53.0%) included a prior personal history of cancer. The frequencies of prior cancers in the queries on females were strongly correlated with US cancer incidences (r=0.97, r2=0.95, P<.001), while the same correlation was weaker among the queries on males (r=0.69, r2=0.47, P=.02).

CONCLUSIONS

The patients entered in the Ask2Me.org tool are a representative cohort of patients with pathogenic variants in cancer susceptibility genes in the United States. While a majority of the queries were on breast cancer susceptibility genes, users also queried susceptibility genes with lower prevalence, which may represent a transformation from single gene testing to multigene panel testing. Owing to these changing tides, more efforts are needed to improve evidence-based clinical decision support tools to better aid clinicians and their practice.
Telehealth Before and During the COVID-19 Pandemic: Analysis of Health Care Workers' Opinions (Preprint)
Authors: Nitiema Pascal
Published: July 2021

BACKGROUND

The COVID-19 pandemic and the lockdowns for controlling the spread of infection have led to a surge in telehealth adoption by many health care organizations. It is unclear how this pandemic has impacted health professionals’ view about telehealth. The analysis of textual data, such as comments posted on a discussion forum, can uncover information that may not be captured by a structured survey.

OBJECTIVE

This study aims to examine the opinions of health care workers about telehealth services during the time frame of March 2013-December 2020.

METHODS

Comments about telehealth posted by health care workers from at least 46 countries were collected from an online discussion forum dedicated to health professionals. The analysis included the computation of sentiment scores from the textual data and the use of structural topic modeling to identify the topics of discussions as well as the factors that may be associated with the prevalence of these topics.

RESULTS

The analysis of the comments revealed positive opinions about the perceived benefits of telehealth services before and during the pandemic, especially the ability to reach patients who cannot come to the health facility for diverse reasons. However, opinions about these benefits were less positive during the pandemic compared to the prepandemic period. Specific issues raised during the pandemic included technical difficulties encountered during telehealth sessions and the inability to perform certain care routines through telehealth platforms. Although comments on the quality of care provided through telehealth were associated with a negative sentiment score overall, the average score was less negative during the pandemic compared to the prepandemic period, signaling a shift in opinion about the quality of telehealth services. In addition, the analysis uncovered obstacles to the adoption of telehealth, including the absence of adequate legal dispositions for telehealth services and issues regarding the payment of these services by health insurance organizations.

CONCLUSIONS

Enhancing the adoption of telehealth services beyond the pandemic requires addressing issues related to the quality of care, payment of services, and legal dispositions for delivering these services.
Virtual Reality-assisted awake brain mapping. (Preprint)
Authors: Bernard Florian , Casanova Morgane , Clavreul Anne , Aubin Ghislaine , Soulard Gwenaelle , Lemée Jean-Michel , Ter Minassian Aram , Seguier Renaud , Menei Philippe
Published: July 2021

BACKGROUND

Preserving major cognitive functions, such as visuo-spatial and social cognition in the surgical management of brain tumors could be decisive for the postoperative quality of life. Using virtual reality during awake brain surgery appears to be interesting for preserving complex cognitive functions. Developing neuropsychological tasks appropriate for use during awake brain surgery using virtual reality technology is challenging.

OBJECTIVE

In this paper, we describe our preliminary experience of extending progressively complex cognitive paradigms via dynamic VR environments during 68 peri-operative brain mapping.

METHODS

This is a single center, retrospective longitudinal study, concerning two cohorts.

RESULTS

A total of 65 patients (30 women, mean age 49.7, range 23-75) operated with VR-assisted Brain mapping were included. At least one VR task (VR-DO 80, VR Estermann or VR-TANGO task) during DES were done for all the patients. The mean duration of surgery was 4 h 30 min, the mean duration of the awake phase was 2 h 15 min. The mean intensity used for DES was 3 mA (Intensity from 0,5 to 8 mA). Mean total duration of VRH use per patient at 16 min (from 10 to 37 min). VR task allowed to preserve language, visual field, visuospatial and social cognition in our serie.

CONCLUSIONS

We show through illustrative cases how VR opens new possibilities for the mapping of complex cognitive functions within the operating theater.

CLINICALTRIAL

ClinicalTrials.gov NCT03010943Virtual reality; awake neurosurgery; visual field; social cognition; visuospatial cognition; unilateral spatial neglect.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/10332.
The Success of Cognitive Activity of Students of the Northern (Arctic) Federal University with Different Levels of Anxietyin Different Time Conditions
Authors:   Federal State Autonomous Education Institution Northern (Arctic) Federal University named after M. V. Lomonosov, Taleeva Anna I. , Madumarova Inobat T. ,   Federal State Autonomous Education Institution Northern (Arctic) Federal University named after M. V. Lomonosov, Zvyagina Natalya V. ,   Federal State Autonomous Education Institution Northern (Arctic) Federal University named after M. V. Lomonosov
Published: July 2021

The dynamic development of the modern world requires the processing and development of a large enough amount of information in a short period of time, which leads to a violation of the psychophysiological and psycho-emotional balance of the person. Violation of the psycho-emotional state leads to the development of increased anxiety. Students need to learn a lot of information in a very short time. The time limit affects students as a stress factor, leads to increased stress and therefore negatively affects the quality of work and in general on the whole body. The aim of the study is to determine the success of cognitive tasks by students of the Northern (Arctic) Federal University with different levels of anxiety in different time conditions. The study used a psychophysiological testing device to determine the level of situational and personal anxiety, to assess the psycho-emotional state used the technique of simple visual-motor reaction, to determine the success of the cognitive task were presented words with one missing letter.
Laboratory indicators in patients with non-severe new coronavirus infection COVID-19
Authors: Trykhlib V.I. , Tsiurak N.R. , Bieliaieva K.P. , Lysenko T.I. , Yeroshenko A.O. , Martynchyk О.S. , Chernyak V.A. , Shevelova T.I. , Popova S.S. , Samoilova S.M. , Chaika S.M. , Holubenko O.S. , Moroz А.V.
Published: July 2021

The article presents literature data on changes in labo-ratory parameters in new coronavirus infection COVID-19 and the results of our own researches. It was found that in the first three days after hospitalization, most patients had normocytosis, a normal number of lymphocytes. In the mild form, there were slightly more people with normal or with an increased number of leukocytes, granulocytes, but in moderate course, leukopenia, lymphopenia, granulocytosis and granulocytopenia, thrombocytosis, thrombocytopenia were registered more often. At the same time, in the mild form, there were more patients with an increased number of band neutrophils. In mild course, there were no individuals with an increased number of band neutrophils after 3 days in the hospital. Leukocytosis, lymphopenia, granulocytosis were no longer detected after 6 days in the hospital; during this period, the number of patients with leukopenia, thrombocytopenia also decreased significantly, most people had normocytosis. In patients with moderate-to-severe course, leukocytosis and leukopenia were observed for a longer period than with the mild course, even after 10 days in hospital. Most patients had normocytosis. By the sixth day of hospital stay, there were more individuals with granulocytosis (no such patients were registered at a later date), with an increased number of band neutrophils. After 6 days, there was greater number of patients with lymphocytosis, thrombocytosis and lymphocytopenia.
Tonsil microbiocenosis and salivary lactate dehydrogenase activity in children with infectious mononucleosis
Authors: Klymenko Kh.P.
Published: July 2021

The article analyzes clinical data, blood test results, tonsil mucus bacteriological testing, and salivary lactate dehydrogenase activity in children with acute infectious mononucleosis caused by an Epstein-Barr viral infection. Research involves 280 children aged from 7 months to 19 years 8 months with infectious mononucleosis, who were hospitalized in the Lviv Infectious Cli-nical Hospital. Group 1 included 234 children infectious mononucleosis caused by Epstein-Barr virus, group 2 — 46 patients with infectious mononucleosis caused by the combination of Epstein-Barr virus and cytomegalovirus. Severe hepatosplenomegaly, lymphadenitis, nasal speech and snoring, hyperthermic syndrome, acute tonsillitis were found in patients with infectious mononucleo-sis. A bacteriological study identified a number of pathogens that can be classified as pathogenic or opportunistic flora. Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Candida fungi were identified in 43.8 % of children with an isolated form of mononucleosis and in 51.7 % of children with mixed infection. In children with infectious mononucleosis caused by mixed infection, we observed the more severe course of the disease and a significantly higher lactate dehydrogenase activity. A significantly increased activity of lactate dehydrogenase in the saliva of patients with infectious mononucleosis in the presence of pathogenic microflora on the mucous membranes indicates destructive processes in the tissues of the tonsils.
Semiología de las Principales Manifestaciones Clínicas
Authors: Contreras-González Noé
Published: July 2021

El libro Semiología de las principales manifestaciones clínicas, editado recientemente por la FES Zaragoza, UNAM aborda aspectos fundamentales de la relación médico paciente, de la entrevista clínica y, en especial, el estudio detallado de las principales manifestaciones clínicas. En este sentido, el estudio semiológico de las manifestaciones clínicas ayuda al juicio y al razonamiento clínico; es decir, la semiología estudia detalladamente el significado de las manifestaciones clínicas; ante un síntoma o signo que presenta el enfermo, el indagar cuándo empezó, a qué se le atribuye, dónde lo ubica el enfermo, cuál es su tipo, cuál es su intensidad, cuál es su horario de predominio, con qué otras manifestaciones se acompaña, qué terapéutica se ha empleado hasta ahora y qué resultados se han obtenido, cómo ha evolucionado y cómo se encuentra actualmente dicha manifestación clínica; todo esto permite ubicar si el padecimiento es agudo o crónico, su probable causa y el aparato o sistema que afecta y cómo se comporta. La semiología de las manifestaciones clínicas constituye un aspecto fundamental para el diagnóstico clínico del enfermo, junto con los antecedentes o factores de riesgo, la exploración física y los estudios paraclínicos. Así, esta obra, aporta contenidos que llenan el vacío existente en la literatura de esta área, apoyando el aprendizaje de los alumnos de medicina, enfermería y odontología
Isolated Power Supply System with Energy Routers and Renewable Energy Sources
Authors: Bulatov Yu N , Kryukov A V , Suslov K V
Published: July 2021

Системы электроснабжения, построенные с использованием технологий Smart Grid, могут быть реализованы на основе энергетических роутеров, выполненных с помощью высокочастотных твердотельных трансформаторов. Энергетические роутеры могут использоваться для подключения установок распределенной генерации, работающих на возобновляемых источниках, а также накопителей электроэнергии для электроснабжения потребителей в изолированной системе. Кроме того, использование энергетических роутеров позволяет улучшить качество электроэнергии в части несимметрии и несинусоидальности напряжения. Приведены результаты моделирования режимов работы изолированной системы электроснабжения, включающей следующие элементы: энергетические роутеры, ветрогенерирующая установка с нечетким регулятором угла поворота лопастей ветротурбины, малая гидроэлектростанция и турбогенераторная установка с прогностическими регуляторами напряжения и скорости вращения ротора. Моделирование выполнялось в системе MATLAB с применением пакетов Simulink и SimPowerSystems. Цель исследований состояла в определении эффективности использования энергетических роутеров в изолированной системе электроснабжения для подключения накопителей электроэнергии и установок распределенной генерации, работающих на возобновляемых источниках энергии. Результаты компьютерного моделирования различных режимов работы позволили сформулировать следующие выводы. Применение энергетических роутеров для подключения к ИСЭС генерирующих установок на возобновляемых источниках энергии позволяет эффективно регулировать напряжение и частоту. В отличие от использования обычных силовых трансформаторов энергетические роутеры позволили получить следующие положительные эффекты: снизить провал частоты в сети 10 кВ при подключении дополнительной нагрузки; уменьшить время переходного процесса для частоты при кратковременном трехфазном коротком замыкании; значительно ограничить провалы напряжения и перенапряжения. Применение прогностических регуляторов скорости вращения ротора у генераторов ТГУ и малой ГЭС позволило убрать колебательность, снизить время переходного процесса и значительно уменьшить перерегулирование для частоты в режимах подключения дополнительной нагрузки и кратковременного короткого замыкания в сети ИСЭС даже при использовании обычных силовых трансформаторов. При резком уменьшении скорости ветра прогностические АРС дополнительно уменьшают колебательность, время переходного процесса и величину перерегулирования. Использование энергетических роутеров позволяет значительно уменьшить влияние на ИСЭС изменений генерируемой мощности установок РГ, работающих на возобновляемых источниках энергии.