bluuebunny/crossref_metadata_2025 huggingface dataset:
Using the Correlation Intensity Index to Build a Model of Cardiotoxicity of Piperidine Derivatives
Authors: Toropova Alla P. , Toropov Andrey A. , Roncaglioni Alessandra , Benfenati Emilio
Published: September 2023

The assessment of cardiotoxicity is a persistent problem in medicinal chemistry. Quantitative structure–activity relationships (QSAR) are one possible way to build up models for cardiotoxicity. Here, we describe the results obtained with the Monte Carlo technique to develop hybrid optimal descriptors correlated with cardiotoxicity. The predictive potential of the cardiotoxicity models (pIC50, Ki in nM) of piperidine derivatives obtained using this approach provided quite good determination coefficients for the external validation set, in the range of 0.90–0.94. The results were best when applying the so-called correlation intensity index, which improves the predictive potential of a model.
Can Pharmaceutical Excipients Threaten the Aquatic Environment? A Risk Assessment Based on the Microtox® Biotest
Authors: Turek Marika , Różycka-Sokołowska Ewa , Koprowski Marek , Marciniak Bernard , Bałczewski Piotr
Published: September 2023

The ecotoxicological impact of pharmaceuticals has received considerable attention, primarily focusing on active pharmaceutical ingredients (APIs) while largely neglecting the potential hazards posed by pharmaceutical excipients. Therefore, we analyzed the ecotoxicity of 16 commonly used pharmaceutical excipients, as well as 26 API–excipient and excipient–excipient mixtures utilizing the Microtox® test. In this way, we assessed the potential risks that pharmaceutical excipients, generally considered safe, might pose to the aquatic environment. We investigated both their individual ecotoxicity and their interactions with tablet ingredients using concentration addition (CA) and independent action (IA) models to shed light on the often-overlooked ecotoxicological consequences of these substances. The CA model gave a more accurate prediction of toxicity and should be recommended for modeling the toxicity of combinations of drugs with different effects. A challenge when studying the ecotoxicological impact of some pharmaceutical excipients is their poor water solubility, which hinders the use of standard aquatic ecotoxicity testing techniques. Therefore, we used a modification of the Microtox® Basic Solid Phase protocol developed for poorly soluble substances. The results obtained suggest the high toxicity of some excipients, i.e., SLS and meglumine, and confirm the occurrence of interactions between APIs and excipients. Through this research, we hope to foster a better understanding of the ecological impact of pharmaceutical excipients, prompting the development of risk assessment strategies within the pharmaceutical industry.
Green-Chemical Strategies for Production of Tailor-Made Chitooligosaccharides with Enhanced Biological Activities
Authors: Thomas Reeba , Fukamizo Tamo , Suginta Wipa
Published: September 2023

Chitooligosaccharides (COSs) are b-1,4-linked homo-oligosaccharides of N-acetylglucosamine (GlcNAc) or glucosamine (GlcN), and also include hetero-oligosaccharides composed of GlcNAc and GlcN. These sugars are of practical importance because of their various biological activities, such as antimicrobial, anti-inflammatory, antioxidant and antitumor activities, as well as triggering the innate immunity in plants. The reported data on bioactivities of COSs used to contain some uncertainties or contradictions, because the experiments were conducted with poorly characterized COS mixtures. Recently, COSs have been satisfactorily characterized with respect to their structures, especially the degree of polymerization (DP) and degree of N-acetylation (DA); thus, the structure–bioactivity relationship of COSs has become more unambiguous. To date, various green-chemical strategies involving enzymatic synthesis of COSs with designed sequences and desired biological activities have been developed. The enzymatic strategies could involve transglycosylation or glycosynthase reactions using reducing end-activated sugars as the donor substrates and chitinase/chitosanase and their mutants as the biocatalysts. Site-specific chitin deacetylases were also proposed to be applicable for this purpose. Furthermore, to improve the yields of the COS products, metabolic engineering techniques could be applied. The above-mentioned approaches will provide the opportunity to produce tailor-made COSs, leading to the enhanced utilization of chitin biomass.
Corrosion Inhibition in CO2-Saturated Brine by Nd3+ Ions
Authors: Canto Jorge , Rodríguez-Díaz Roberto Ademar , Martinez-de-la-Escalera Lorenzo Martinez , Neri Adrian , Porcayo-Calderon Jesus
Published: September 2023

This study reports the use of an inorganic corrosion inhibitor to mitigate dissolved CO2-induced corrosion. Using electrochemical techniques (polarization curves, open circuit potential, polarization resistance, and electrochemical impedance), the effect of adding Nd3+ ions on the corrosion resistance of X52 steel immersed in CO2-saturated brine at 20 °C and 60 °C was evaluated. The polarization curves showed that the Icorr values tend to decrease with increasing Nd3+ ion concentration, up to the optimal inhibition concentration, and that the corrosion potential increases at nobler values. Open circuit potential measurements showed a large increase in potential values immediately after the addition of the Nd3+ ions. Similarly, polarization resistance measurements showed similar trends. It was observed that regardless of temperature, Nd3+ ions can reduce the corrosion rate by more than 97% at doses as low as 0.001 M. Electrochemical impedance measurements confirmed the formation of a protective layer on the steel surface, which caused an increase in the magnitude of the impedance module and phase angle, which indicates an increase in the resistance to charge transfer and capacitive properties of the metallic surface. The characterization of the metallic surface showed that the protective layer was formed by Nd carbonates, whose formation was due to a CO2 capture process.
The Roles of MicroRNAs in Obesity: Emphasizing Links with Chronic Kidney Disease and Cardiovascular Disorders
Authors: Metzinger-Le Meuth Valérie , Metzinger Laurent
Published: September 2023

Obesity has become a global epidemic, contributing to the development of numerous chronic diseases, including diabetes, chronic kidney disease (CKD) and cardiovascular disorders. MicroRNAs (miRNAs) have emerged as key regulators in various biological processes, including metabolism, inflammation, and tissue remodeling, making them pivotal players in obesity-related pathologies. This review aims to provide comprehensive insights into the roles of miRNAs in obesity, with a particular emphasis on their involvement in the pathogenesis of CKD and cardiovascular disorders. We highlight the involvement of specific miRNAs in adipose tissue development, energy homeostasis, inflammation, and insulin resistance, contributing to the pathogenesis of obesity. Moreover, we explore the impact of miRNAs on renal fibrosis and inflammation, giving clues on their roles in the development and progression of CKD. Additionally, we discuss the influence of miRNAs on endothelial dysfunction, atherosclerosis, and cardiac remodeling, emphasizing their contribution to obesity-related cardiovascular disorders. Understanding the regulatory functions of miRNAs in these interconnected conditions holds promise for improved diagnosis, prognosis, and therapeutic interventions. Indeed, miRNAs are potential diagnostic biomarkers for obesity-related diseases, although challenges remain to be elucidated before their clinical translation. Furthermore, we highlight the emerging strategies that target miRNAs as therapeutic interventions to mitigate the detrimental effects of obesity on kidney and cardiovascular health.
Composition and Textural Characteristics of Char Powders Produced by Thermomechanical Processing of Sunflower Seed Husks
Authors: Frolov Sergey M. , Silantiev Anton S. , Sadykov Ilias A. , Smetanyuk Viktor A. , Frolov Fedor S. , Hasiak Yaroslav K. , Dudareva Tatiana V. , Bekeshev Valentin G. , Grishin Maksim V. , Golubev Evgeniy K. , Baimukhambetova Dinara , Popkova Vera Ya. , Vezentsev Alexander I. , Razdobarin Alexander E. , Yapryntsev Maxim N. , Sokolovskiy Pavel V.
Published: September 2023

The paper presents the results of experimental studies on the production of fine char powder from sunflower seed husks by a novel method of thermomechanical treatment with pulsed shock waves and supersonic jets of the mixture of ultra-superheated (above 2000 °C) steam and carbon dioxide, as well as the results of examination of the produced char powder in terms of its chemical, phase, and granulometric composition and structural, morphological, and texture characteristics. The objective of the research is to explore the possibility of using the resulting char powder as a sorption-active material for organic substances. It is shown that the obtained char particles and their agglomerates have an average size of 20–30 nm and 12–24 µm, respectively, have the shape of disks and ellipsoids, consist mainly of amorphous carbon (up to 56 wt%) and oxygen (up to 42 wt%), and have a specific surface area of 1.1–1.7 m2/g. It is concluded that such a char powder can be used as an absorbent for organic substances when dried and deagglomerated.
Combustion Process of the Compound Supply CNG Engine
Authors: Zhu Zhiqiang , Zhang Defu , Jiao Yunjing
Published: September 2023

Objective: In order to study the lean combustion process of a natural gas engine by separating the combustor, a spark ignition natural gas engine with separated combustors was retrofitted from a S195 single-cylinder diesel engine. Methods: The electronic control system controlled the gas supply and the spark plug ignition. A low pressure injection valve was set in the inlet pipe to form a lean mixture while a high pressure injection valve was placed in the subsidiary chamber to create a rich mixture, which was then ignited and injected into the main combustor, where the lean mixture was subsequently ignited again to achieve stratified combustion. Results: The test results showed that steady ignition is feasible in the system and verified the impact of the shape of the main combustor on HC, the impact of channel diameter on NOX production, and the impact of the ratios of high-pressure gas and low-pressure gas on HC and NOX. The combustion conditions of high-pressure gas and low-pressure gas in the engine combustor vary greatly. Our results signify that the shape of the main combustor has a great impact on the performance of the engine, that is, a shorter propagation distance can reduce the generation of HC. Conclusion: The best ignition advance angle under different conditions was determined using a spark ignition natural gas engine. The ratios of high-pressure gas and low-pressure gas greatly impact the performance and emission of the engine. The reduced diameter of the channels between the main and subsidiary combustors can enhance the stratification and facilitate the secondary ignition.
Editorial to the Special Issue “Feature Papers in Psychometrics and Educational Measurement”
Authors: Robitzsch Alexander
Published: September 2023

The Special Issue “Feature Papers in Psychometrics and Educational Measurement” (https://www [...]
Three-Party Password Authentication and Key Exchange Protocol Based on MLWE
Authors: Guo Songhui , Song Yunfan , Guo Song , Yang Yeming , Song Shuaichao
Published: September 2023

With the rapid development of quantum theory, the discrete logarithm problem and significant integer factorization problem have polynomial solution algorithms under quantum computing, and their security is seriously threatened. Therefore, a three-party password-authenticated key agreement scheme based on module learning with errors problem was proposed, and its security was proved in the BPR model. Compared with other password-authenticated key agreement protocols, the proposed protocol has higher efficiency and a shorter key length, which can resist quantum attacks. Therefore, the protocol is efficient and secure and suitable for large-scale network communication.
GAYA HIDUP MEROKOK, MINUM KOPI, POLA ISTIRAHAT DAN TEKANAN DARAH PADA DEWASA MUDA DI PETRIKORA
Authors: Audina Sheylla Tara , Suiraoka Putu , Widarti IGA Ari
Published: September 2023

Based on Health Profile of Badung Regency on 2018, the prevalence of people with hypertension that received health care are 76,7% of the total population. The objective of this research is to find out the blood pressure based on the life style from adults. Observational method is used on this research, by using comparation from 30 samples. There are 2 types of data used, primary and secondary data. The method of collecting data is through interview, questionnaire and recording. The samples which have behavior of drinking coffee (66.67%) and the samples which do not drinking coffee (33.33%). The samples which have behavior of smoking (56.67%) and the samples who do not smoke (43.33%). Samples that have the behavior of drinking coffee have high blood pressure on average 140/80 mmHg, samples that have behavior of smoking have high blood pressure on average 140/80 mmHg, and samples that have poor rest patterns have high blood pressure on average 140/80 mmHg. In this case, for the visitor who have certain life style such as the behavior of drinking coffee, staying up late and smoking, are expected to apply healthy life style for maintaining health.Keywords : blood pressure, coffee, smoking, rest patterns
Tingkat Konsumsi Lemak Hewani Dan Kejadian Hipertensi Di Desa Banjarangkan Kecamatan Banjarangkan Kabupaten Klungkung
Authors: Yanti Ni Luh Pt. Armini , Kusumajaya Anak Agung Ngurah , Padmiari Ida Ayu Eka
Published: September 2023

Hipertensi atau penyakit tekanan darah tinggi adalah suatu gangguan pada pembuluh darah yang mengakibatkan suplai oksigen dan nutrisi, yang dibawa oleh darah, terhambat sampai ke jaringan tubuh yang membutuhkan.. Hipertensi erat kaitannya dengan pola makan yang salah. Hipertensi sering ditemukan di masyarakat dengan konsumsi lemak berlebih terutama lemak jenuh yang berasal dari hewani seperti daging-dagingan kususnya daging merah. Tujuan dari penelitian untuk mengetahui hubungan, tingkat konsumsi lemak hewani dengan kejadian hipertensi di Desa Banjarangkan, Kecamatan Banjarangkan, Kabupaten Klungkung. Jenis penelitian yang digunakan adalah observasional dengan rancangan cross sectional. Sampelpenelitian berusia 38 - 55 tahun sebanyak 63 orang yang diambil secara proporsional random sampling. Data yang dikumpulkan meliputi data, identitas sampel,  tingkat konsumsi lemak hewani, dan tekanan darah. Data diolah dan dianalisis secara univariat dan bivariat. Hasil penelitian menemukan sebanyak42,9 % mengalami hipertensi. Yang didapatkan dari kejadian hipertensi yaitu dari 63 sampel yang telah diteliti, dari 36 sampel dengan status tekanan darah normal, sebagian besar tingkat konsumsi lemak hewani sampel kurang yaitu sebanyak 23 sampel  (63,9%). Pada 27  sampel dengan status hipertensi seluruhnya (100,0%) tingkat konsumsi lemak hewani sampel tersebut tinggi. Dari uji koralasi product moment pearson yang dilakukan diperoleh nilai  p=0,001 yang artinya pada taraf signifikan 5%  ada hubungan tingkat konsumsi lemak hewani dengan kejadian hipertensi
What is the role of contact with animals in covid 19 pneumonia?
Authors: SARIHAN Aydın , ERAYBAR Suna , KORAN Serhat , CAN Çağdaş , ERDEMİR İsmail , RAHMAN Fatih , BULUT Mehtap
Published: September 2023

Introduction: The novel corona virus (COVID-19) is considered to spread from person to person. There is no clear evidence that animals play a role in the spread of COVID-19.

Objectives: The subject of this study was the correlation between pet contact and COVID-19 pneumonia.

Patients and Methods: The participants were questioned by creating contact categories of indoor, garden, street and workplace as contact environments with pets.

Results: No statistically significant correlation was found when the COVID-19 patients who came into contact with pets in the home were compared whether they had COVID-19 pneumonia or not.

Discussion: Despite the fact that the probability of spread to humans from cats and dogs is low, COVID-19 can be spread to cats and dogs. In this study, it was detected that while those who came into contact with dogs were not different from those who were in contact with dogs, they had more lung involvement than those who had outdoor contact, which suggests that various mechanisms may play a role in virus spread.
Psöriatik Artrit Hastalarında C-Reaktif Protein/Albümin Oranının Klinik Önemi
Authors: USLU Sadettin , KOR İrem
Published: September 2023

Giriş ve Amaç: C-reaktif protein (CRP)-albümin (ALB) oranı (CAO), yeni bir inflamatuar biyobelirteç olarak ortaya çıkmıştır. Çalışmanın amacı, psoriatik artrit (PsA) hastalarında CAO'nın klinik önemini değerlendirmektir.

Gereç ve Yöntem: 76 PsA hastası ve 48 sağlıklı kontrol grubu çalışmaya dahil edildi. Hastalar ve kontrollerden onam alındıktan sonra dosya kayıtları incelenerek, demografik bilgiler, başvuru anındaki klinik ve laboratuvar bulguları, nötrofil/lenfosit oranı (NLO), monosit/lenfosit oranı (MLO), trombosit/lenfosit oranı (PLO) ve C-reaktif protein/albümin (CAO) kaydedildi. PsA spesifik bir cilt tutulum ölçütü olan PASI skoru ve şiş-hassas eklem sayıları PsA'daki hastalık aktivitesinin ölçütleri olarak kullanıldı. CAO ile hastalık aktivite belirteçleri (Şiş-hassas eklem sayısı, PASI) ve geleneksel akut faz reaktanları [Eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP)] arasındaki korelasyona bakıldı.

Bulgular: PsA hastalarında CAO, sağlıklı gruptan önemli ölçüde yüksekti (p
Contribución al desarrollo de la cadena de valor de ganado menor en Cuba: una mirada desde la innovación y la tecnología
Authors: Lama Juan Pérez , Sánchez Zamir Cobas , Serrano Boris Ramos , Torrecilla Jorge Carlos González , Pedroso Juan Fajardo , Olmedo Justo Lorenzo González
Published: September 2023

Una de las tareas fundamentales en Cuba es alcanzar la soberanía alimentaria desde lo local, para ello el incremento del ganado menor, adquiere una creciente importancia. El presente artículo hace una contribución al desarrollo de la cadena de valor de ganado menor, haciendo referencia al caso caprino, incorporando elementos de ciencia e innovación sobre bases agroecológicas. Esta experiencia permite adquirir nuevas razas más productivas de leche y carne, a través de la mejora genética. De igual manera, permite el desarrollo de productos lácteos a partir de la leche de cabra, elevando la eficiencia, calidad y competitividad de las diferentes actividades de forma sostenible en materia socioeconómica, tecnológica y ambiental, en los sectores estatal y no estatal, que incluye el cooperativo y campesino y productor individual, aportando así al desarrollo local.
A importância de inspeções preventivas no aumento da efetividade do sistema de gerenciamento da segurança operacional das instalações marítimas de produção de petróleo e gás natural
Authors: Dourado Robson José , Figueiredo Aureo Emanuel Pasqualeto , Pacheco Marcos Tadeu Tavares
Published: September 2023

Mesmo em um cenário de transição energética, a indústria do petróleo e gás natural continua desempenhando um papel fundamental para suprir a demanda de energia dos próximos anos. No Brasil este panorama não é diferente sendo que a contribuição das instalações marítimas de produção no atendimento da demanda nacional de petróleo é extremamente relevante (97% em 2021). Com este protagonismo, o crescimento seguro e sustentável da indústria é condição estratégica para o país e a prevenção de incidentes que possam ocasionar danos a vida e ao meio ambiente é um dos requisitos para este atendimento. A ANP – Agência Nacional de Petróleo, Gás Natural e Biocombustíveis atua na regulação, contratação e fiscalização das atividades econômicas integrantes da indústria do petróleo, sendo este órgão um catalizador para aprimoramento da performance em segurança operacional junto às empresas reguladas. Na atividade de fiscalização, o histórico de não conformidades lavradas pelo órgão regulador explicita importantes feedbacks à indústria devendo ser insumos para a melhoria contínua do sistema de gestão de segurança operacional das empresas. A metodologia proposta neste trabalho correlaciona as lições aprendidas das auditorias externas promovidas pela ANP com as boas práticas para auditorias internas formuladas pela indústria sob coordenação do IBP numa abordagem de inspeções preventivas. Com frequência quadrimestral distinta das auditorias internas (normalmente dois anos) e com foco práticas de gestão com performance aquém do requerido conforme histórico se pretende com esta metodologia contribuir para melhoria da segurança operacional nas instalações de produção e trilhar o caminho da sustentabilidade da indústria de forma geral.
Uma experiência com mundos encantados: a importância da literatura infantil nos anos iniciais do ensino fundamental
Authors: Almeida Amanda Roberta , Buchinger Carolina Arceles , Bandeira Larissa de Queiroz , Marques Natalia Anzolin , Mazzuco Neiva Gallina
Published: September 2023

Este artigo originou-se das experiências vivenciadas na disciplina de Estágio Supervisionado, sob a forma de Prática de Ensino II direcionada aos Anos Iniciais do Ensino Fundamental. O objetivo central é relatar e refletir a respeito das ações de observação e de regência em classe.  Para tanto, aplicou-se um projeto didático na área da Literatura Infantil, voltado a turmas de 1º e 2º anos do Ensino Fundamental de uma Escola Municipal localizada em Cascavel - PR, explorando-se a história O Caso do Bolinho, de Tatiana Belinky, e outras atividades a partir da narrativa. Durante as aulas ministradas, pudemos aprofundar os estudos acerca da história da Literatura Infantil, área do conhecimento relevante e que contribui para compreendermos nossas emoções ou a realidade em que estamos inseridos, além de nos tornar mais críticos, criativos e sensíveis (COELHO, 2000; ÁVILA; ALMEIDA, 2015). Na etapa da alfabetização, a Literatura Infantil é fundamental, principalmente pelo constante contato que a criança tem com o mundo da escrita, e isso deve ser aproveitado pelos professores, ao oportunizarem momentos que envolvem o lúdico, o imaginário, a criatividade e outros aspectos. Adquirimos, desse modo, muitas experiências e aprendizagens nesse período que, com certeza, agregarão em nossa futura atuação profissional.
IMPLEMENTASI PROGRAM TANGGUNG JAWAB SOSIAL DAN LINGKUNGAN DALAM MENDUKUNG PENGEMBANGAN USAHA MIKRO KECIL SUPPLY CHAIN DI PT PLN (PERSERO) PUSHARLIS
Authors: Fasya Ghitha Zahirah , Hendriyani Chandra , Damayanti Fenny
Published: September 2023

Business continuity is highly dependent on a harmonious relationship between the company and its supporting ecosystem such as employees, customers and the environment. To support this, the company must implement a Social and Environmental Responsibility (TJSL) program. The purpose of implementing the TJSL program is to contribute to the development of micro and small businesses or local communities. PT PLN (Persero) Pusharlis has a TJSL priority on the economic pillar through the development of the UMK Supply Chain which is in line with the 2030 Sustainable Development Goals (SDGs) goals of reducing poverty, unemployment, and improving people's welfare. This study uses a qualitative method with a descriptive approach to data collection techniques through interviews and literature studies. The object of research is CV Karya Mandiri Manufacture which is a fostered partner of PT PLN (Persero) Pusharlis which has succeeded in increasing production requests by 75 requests from the previous 50, resulting in an increase in employment of 22.2%. Thus it can be concluded that the TJSL program at PT PLN (Persero) Pusharlis was able to increase economic growth and absorb labor in the MSE Supply Chain. 

Key words: Social and Environmental Responsibility, TJSL, MSE, Supply Chain
THE SUSTAINABILITY REPORTING WITHIN THE ASEAN COUNTRIES; A BIBLIOMETRIC ANALYSIS REVIEW
Authors: Sayuti Alfian , Aprianto Dedi
Published: September 2023

Sustainability reporting is  one of the company’s efforts to present non-financial information to stakeholders. It is hoped that this will increase the company’s transparency in all its activities related to the environment, social and economy. This study used a bibliometric analysis related to the previous studies related to the issue of sustainability reports. The current study was conducted by using data from the Scopus sources. The keyword used is sustainability reporting with a total data of 428 documents. The current study was carried out only for the ASEAN countries. The research identified several things including research contributions by countries, journals, topics, keywords, authorships, and affiliations. The finding shows that the ASEAN countries dominating the so-called studies related to the sustainability reporting is Malaysia and Indonesia. The mostly-used keywords are sustainability and sustainability reporting. This study also presents the data on journal affiliations and publishers who contributed to this study. The results have limitations including data sources and supporting software used. Sources of data only come from articles accredited by Scopus, then the data obtained is processed using only 1 software. The novelty of this research is to analyze the sustainability report issues by using a Bibliometric model in the ASEAN countries. It is expectedly used to provide more insight towards researchers and academia interested in discussing under sustainability reporting issues.
ANALISIS KEMISKINAN DI WILAYAH III CIREBON
Authors: Istiandari Debby Nindya
Published: September 2023

This is research about the effect of population, mean years of school, and covid-19 on poverty in district/city area III Cirebon including Cirebon City, Cirebon Regency, Indramayu Regency, Majalengka Regency, and Kuningan Regency. The data type in this study was secondary data for the period of 2010-2021 and cross data of five areas, whereas the data analysis technique used was panel data regression analysis. According to the result of analysis, it was found that: (1) the population brings an insignificant positive effect on the poverty, (2) the mean years of school brings a significant negative effect on the poverty, (3) the covid-19 brings a significant negative effect on poverty with the significant rate of 5 percent.
Kentlerde Kuş Göç Yolları Üzerindeki Biyoçeşitliliğin Peyzaj Tasarım Uygulamaları ile Desteklenmesi: Çankırı Örneği
Authors: ŞAHİN KÖRMEÇLİ Pelin , CEYLAN Kevser Sena
Published: September 2023

Günümüzde dünya genelinde hızla artan kentleşme, doğal ekosistemler üzerinde büyük bir baskı oluşturmaktadır. Bu süreçte ekosistemin bir parçası olan kuş göç yollarının özellikle kentlerdeki biyoçeşitlilik için önemi büyüktür. Hızla artan yoğun kentleşme ile doğal yaşam alanları daralan kuşlar için biyoçeşitliliği destekleyecek tasarım uygulamalarının geliştirilmesine ihtiyaç duyulmaktadır. Bu kapsamda kuş göç yolları üzerinde yer alan ve ekolojik değerleri ile gelişim potansiyeline sahip olan Çankırı ili kent merkezi çalışma alanı olarak seçilmiştir. Çalışmanın amacı kuş göç yolları üzerinde tasarım önerileri geliştirerek kentsel biyoçeşitliliğin desteklenmesidir. Çalışmanın ilk aşamasında BirdLife International kuruluşunun geliştirdiği analiz aracı (Soaring Bird Sensitivity Mapping Tool) ile Çankırı kenti üzerinden geçen kuş göç yolları ortaya çıkarılmıştır. Çalışmanın ikinci aşamasında ise söz konusu göç yolları üzerinden alt sistem biyotoplarına göre tasarım önerileri geliştirilmiştir. Türlerin ihtiyaçlarına uygun olarak düşünülmüş ve yeşil altyapıyı destekleyen tasarım uygulamaları kuşlar için kentlerde yaşam alanları oluşturmakta ve kent ekosisteminin sürdürülebilirliğine katkıda bulunulmaktadır.
Ultzamako barietatearen aditzaren berezitasunak: isoglosa nagusienak
Authors: Ibarra Murillo Orreaga
Published: September 2023

Lan honen bidez, Ultzamako aditz sisteman aurkitzen diren berezitasun nabarmenenak aztertzea dugu helburutzat. Hamar ezaugarri aukeratu ditugu, garrantzi gehien daukatenak banaketa diatopikoari dagokionean, hain zuzen ere. Berauen bidez, Ultzamako aditzean sortzen den desberdintasuna, batzuetan graduzkoa eta besteetan bapatekoa, erakusten da. Aldi berean Ultzamako euskarak -erdialdeko euskalki bezala- ondoko hizkerekin dituen kidetasunak azpimarratzen saiatzen gara, bereziki Goi Nafarrera hegoaldekoarekin, zeinarekin kidetasun asko erakusten dituen.
Otxandio aldeko hiketaren berezitasunez
Authors: Burguete Ajuria Xabier
Published: September 2023

Artikulu honetan lehenengo zatian, Otxandio aldeko aditz alokutiboa eta utxandioko euskara barietate berdinekoak diren Ubide eta Oletakoe kin konparaketa bat erakutsi nahi da, berezitasun aspagarriena emakume seksu markaren gabezia eta "-n" iragan markaren gabeziak direlarik neurri desberdinetan hiru herriotan. Halaber, berezitasun hauek kontuan hartuta, beste konparaketa labur bat egin nahi izan dut Zuberoera eta Erronkariera, Lehenengoa "-n" iragan marka gabekoa hitanoan eta honen eta emakume saksu marka gabekoa bigarrena. Bestalde, bigarren atalean Otxandioko hitanozko menpeko esaldiek hika aditz laguntzaileetan duten eraginak ikusten dira.
Une étymologie du mot basque bildots
Authors: Schwerteck Hans
Published: September 2023

D'après la description historique de "Cabeiço das Frágoas", Amonio Tovar a interprété les mots oilam usseam comme "brebis d'une année". Cette explication peut servir comme base pour expliquer le mot basque bildots "mouton". Le seul problème c'est de savoir pour que! mocif le -l- de oila s'est converti en basque en -ld-.
EFEKTIVITAS PROGRAM PENGEMBANGAN USAHA AGRIBISNIS PERDESAAN TERNAK BABI PADA GAPOKTAN OLADIKE DI DESA KWAELAGA LAMAWATO, KECAMATAN ADONARA TIMUR, KABUPATEN FLORES TIMUR (Effectiveness of the rural agribusiness development program for pig farming in....)
Authors: Sanga Hendrikus T. , Lole Ulrikus Romsen , Sogen Yohanes G. , Krova Maria
Published: September 2023

The PUAP program is a program developed by the Ministry of Agriculture to address problems in agribusiness related to capital, marketing, human resources, business management, and group management that have an influence on farmer productivity. However, the problem that wants to be studied is how the level of effectiveness of the PUAP program on pig farms in Gapoktan Oladike, Kwaelaga Lamawato Village, East Adonara District, East Flores Regency. The aim of the study was to analyze the effectiveness of the PUAP program on pig farming in the Oladike Farmers' Association. The research was conducted in the village of Kwaelaga Lamawato which includes a group of farmers in the Oladike Gapoktan. Respondents were taken from group members, group administrators, PPL, village heads, related offices, and other stakeholders. Data analysis uses effectiveness analysis to analyze the effectiveness of the PUAP program. The conclusion of the study is that based on Likert's assessment and the percentage of the effectiveness of the program's inputs, processes, and outputs, it turns out to be in the effective category, so that in general the Rural Agribusiness Development Program (PUAP) in the pig farming business has carried out the PUAP program well by Gapoktan Oladike. It is recommended that with better business management, the PUAP program will have a positive impact so that it is expected to maintain its sustainability, both the PUAP program and similar programs.
ANALYSIS ON THE UNIFORMITY OF SEED SOWING IN THE SPRAYING MACHINE OPERATING ON THE GRASSLAND
Authors: YAN Chen , ZHANG Wenxia , HUA Guo , SHI Fu , RUI Zhang , MING Zhang
Published: September 2023

In the process of revegetation of degraded grassland by pneumatic seed sprayer, the working parameters of the sprayer, such as the position of the sprayer and the air velocity of the inlet of the sprayer, have an impact on the uniformity of spraying. In this paper, 4BQD-40C pneumatic sprayer is taken as the research object. The influence of the compensation mechanism on the airflow velocity at the inlet of the barrel nozzle and the spraying quality is analyzed. The conclusions show that: (1) The planting trajectory of the sprayer inlet compensation mechanism is analyzed, and the planting trajectory equation is obtained, which lays a foundation for subsequent research. (2) The influence law of the opening height on the inlet airflow velocity of the nozzle is obtained, and the drop trajectory is adjusted by adjusting the inlet airflow velocity of the nozzle, and the area of the missed seeding area is reduced. (3) The time points of opening height adjustment and reset of the compensation mechanism in one cycle were obtained. At the same time, there is a lag time t1 due to changing the seed drop trajectory by adjusting the nozzle inlet airflow velocity. Due to this lag time, the compensation mechanism can be used to change the seed drop trajectory when the swing frequency is less than 7.3 min-1 to achieve optimization of the reseeded and missed seeding areas.
STUDY OF THE TURNING PROCESS OF THE BRIDGE TYPE MACHINES
Authors: BULGAKOV Volodymyr , IVANOVS Semjons , KUVACHОV Volodymyr , ADAMCHUK Valerii , KAMINSKIY Viktor
Published: September 2023

One of the ways to improve the maneuverability of wheeled axle machines when they move along the tracks of a constant technological track is the use of onboard turning. This simplifies the layout, increases the useful volume of the machine due to the release of niches in the machine body, necessary for placing the steering wheels when turning. However, the question of the efficiency of onboard turning of axle machines by the criterion of power input remains insufficiently studied. The aim of the research is to substantiate the criterion of the power required to implement on-board turns of an overhead machine. Theoretical research, synthesis of design schemes, parameters and modes of operation of bridge machines have been carried out by simulating on a personal computer the conditions of their functioning. The basics of theoretical mechanics and tractor theory were the basis of the research methods. As a result of the research, it has been established that power (onboard) turning is widely used for wheeled machines and has a prospect of application on bridge machines used in the track farming system. Approbation of the developed methodology of determining power inputs for power (onboard) turning of wheeled axle machines has shown that under the accepted conditions of turning the power required for turning of the axle machine is 28% of the engine power at a speed of 5 km⸱h–1. As the gauge of the bridge machine increases, the total power required for the power (onboard) turn increases exponentially.
DESIGN AND EXPERIMENT OF FILM LAYING QUALITY MONITORING SYSTEM FOR COTTON PRECISION PLANTER
Authors: BAI Shenghe , YUAN Yanwei , XING Gaoyong , WEI Liang , NIU Kang , ZHOU Liming , ZHAO Bo , WEI Liguo , LIU Lijing
Published: September 2023

To realize real-time monitoring of film laying process of cotton precision planter and improve intelligent level of cotton precision planter, based on advanced morphological filtering method and graphical programming of Labview software, a film laying quality monitoring system of cotton precision planter is designed. Using the Vision Assistant visual assistant, the system uses a color extraction function to convert colors to grayscale images. It uses LOOKup Table function and FFT filter function to perform grayscale transformation, binarization and advanced morphological filtering on it respectively. It then uses basic morphology to acquire various components in the plastic film image. It realizes the monitoring of parameters such as the width of the daylighting surface, the side length or seam length of the mechanical damaged part, and the width of the film edge covering soil. The performance test results of the film laying quality monitoring system showed that the system worked stably and reliably, the average monitoring accuracy of the width of the lighting surface and the width of the film edge covering soil reached more than 95%, and the average monitoring accuracy of the side length or the length of the seam at the mechanical damage part reached more than 88%. It solved the problems of difficulty in recognizing the similarity between the plastic film and the background interferer (soil, etc.) and could accurately detect the quality of the cotton film in real time. It effectively improved the operation quality and working efficiency of the cotton precision planter and met the practical requirements of film laying monitoring.
An Analysis of L1 Influence of Delexical Verbs Collocations on Turkish EFL Learners’ Performances
Authors: KİMSESİZ Fatma
Published: September 2023

Mainly involving congruent and non-congruent collocations across English and Turkish, this study aimed to examine EFL learners’ performances in associating the given delexical verbs collocations between English and Turkish. The study involved a corpus-based selection of delexical verbs collocations. Data were collected from 43 participants who were applied a translation test with 24 items. The findings were examined according to error analysis. Employing a mixed method design, the study involved descriptive analysis of learners' scores, sources of learners’ errors, and an evaluation of L1 influence on learners’ test results. The findings showed that EFL learners’ score was higher with congruent delexical verbs collocations compared to non-congruent collocations. The findings also elicited L1 transfer had influence on EFL learning and assumed similarity might cause errors in associating verb collocations with their target language equivalents. The study offers some significant implications for both the learners and language instructors.
Analisis Pemberian Propolis terhadap Kadar CA 15-3 Kasus Kanker Payudara Stadium Lanjut
Authors: Pai Filandy , Manginstar Christian , Merung Marselus , Langi Fredrik G.
Published: September 2023

Abstract: Breast cancer is the first rank of cancer incidence and the second mortality rate in Indonesia. Propolis is already known as a potential anticancer agent. This study aimed to evaluate the effect of propolis administration on CA 15-3 level in breast cancer patients. This was a quasi experimental study with a pre and post test design. Subjects were patients with advanced breast cancer at the Surgery-Oncology polyclinic and Surgery nursing room at Prof. Dr. R. D. Kandou Hospital Manado from June 2022 to March 2023. There were 20 patients with breast cancer in this study, divided into two groups (treatment and control groups) with age and cancer location. Data were analyzed with th independent t-test. The results showed that the increase of CA 15-3 level in treatment group was 8.3±3.5 U/mL meanwhile in the control group was 11.4±3.4 U/mL. There was no significant difference in the increased level of CA 15-3 in the two groups (p=0.069). In conclusion, propolis administration has descriptive effect on breast cancer patients with lower increase of CA 15-3 level compared to the control group, however, there is no significant difference between the two groups.
Keywords: propolis; breast cancer; CA 15-3 marker
 
Abstrak: Kanker payudara menduduki peringkat pertama insidensi kanker dan angka mortalitas kedua di Indonesia. Propolis telah dikenal sebagai agen antikanker yang potensial. Penelitian ini bertujuan untuk mengevaluasi efek pemberian propolis terhadap kadar plasma CA 15-3 penderita kanker payudara. Penelitian ini menggunakan metode kuasi eksperimental pre dan post tes dengan desain potong lintang. Subjek penelitian ialah pasien kanker payudara stadium lanjut di Poliklinik Bedah-Onkologi dan Ruang Perawatan Bedah RSUP Prof. Dr. R. D. Kandou Manado sejak bulan Juni 2022 hingga Maret 2023. Jumlah subjek penelitian sebanyak 20 pasien, dibagi atas dua kelompok (kelompok uji dan kontrol) dengan data demografi usia dan lokasi kanker. Uji satistik yang digunakan ialah uji t tidak berpsangan. Hasil penelitian mendapatkan peningkatan kadar CA 15-3 kelompok uji ialah 8,3±3,5 U/mL sedangkan pada kelompok kontrol sebesar 11,4±3,4 U/mL. Tidak didapatkan perbedaan bermakna untuk kenaikan CA 15-3 pada kelompok uji dan kelompok kontrol (p=0,069). Simpulan penelitian ini ialah pemberian propolis pada pasien kanker payudara stadium lanjut secara deskriptif berefek dengan kadar peningkatan CA 15-3 yang lebih rendah dibandingkan kelompok kontrol tetapi secara statistik tidak terdapat perbedaan bermakna antara kedua kelompok penelitian.
Kata kunci: propolis; kanker payudara; penanda CA 15-3
Il ruolo dell’Ue nella diffusione dei diritti fondamentali in Stati terzi: strumenti vincolanti e adeguamento “spontaneo” agli standard dell’Unione
Authors: Adinolfi Adelina
Published: September 2023

Il Trattato dell’UE prevede che l’Unione debba promuovere i propri valori nelle relazioni con i Paesi terzi al fine di consolidare e sostenere il rispetto dei diritti umani. Questo ruolo è svolto dall’Unione mediante una varietà di strumenti che, fondandosi sulla rilevanza del mercato interno e sui meccanismi della politica commerciale comune, stabiliscono regole (in accordi o atti normativi) volte a promuovere il rispetto dei diritti umani e a contrastarne le violazioni. Nella prassi recente, a questi meccanismi di natura vincolante si accompagnano dinamiche di natura “spontanea” che favoriscono la diffusione in Stati terzi degli standard di tutela dei diritti fondamentali accolti dall’Unione. L’articolo si propone una ricognizione delle diverse modalità attraverso le quali avviene tale diffusione, considerando sia i comportamenti posti in essere da soggetti privati, sia i fattori che possono favorire l’adozione in Stati terzi di soluzioni normative che ricalcano il modello europeo di regolazione. È infine rilevata una (emergente) tendenza dell’Unione a costruire, in alcuni ambiti strategici, un proprio ruolo di regolatore globale, sia entrando nella competizione normativa con i Paesi leader nello sviluppo tecnologico, sia facendo ricorso a strumenti di cooperazione e di dialogo politico con Stati terzi e nell’ambito di organizzazioni internazionali.

The EU Treaty requires the Union to promote its values ​​in the relations with third countries to consolidate and support respect for human rights. This role is performed by the Union through a set of different tools which, grounding on the relevance of the internal market and on the mechanisms of the common commercial policy, establish rules (through international agreements or legislation) aimed at promoting respect for human rights and combating violations of the same. In recent practice, these tools having binding force are complemented by new paths of a "spontaneous" nature which favor the diffusion in third countries of the standard of protection of fundamental rights accepted by the Union. The article proposes a survey of the different ways in which this diffusion takes place, considering both the behaviors put in place by private subjects and the factors that can favor the adoption of regulatory solutions that follow the European regulatory model. Finally, the article detects an (emerging) tendency for the Union to build, in some strategic areas, its own role as a global regulator, both by entering into regulatory competition with the leading countries in technological development, and by resorting to policy dialogue and cooperation instruments with third countries and within international fora.
L’individuo al cospetto del potere disciplinare
Authors: Stacca Serena
Published: September 2023

Il potere disciplinare, malgrado la sua essenza punitiva, non è regolato per proteggere la posizione del singolo colpito dalla sanzione. È infatti sbilanciato a favore della comunità nella quale si esplica. Ne sono riprova l’atipicità delle infrazioni, l’applicazione di norme vaghe e indeterminate, la peculiare composizione delle autorità disciplinari, i limiti del sindacato giurisdizionale. Si pone così un problema di compatibilità del fenomeno con l’ordine costituzionale.

Disciplinary power, despite its punitive essence, is not regulated to protect the position of the individual affected by the sanction. It is in fact biased in favor of the community in which it is expressed. This is demonstrated by the atypical nature of the infringements, the application of vague and indeterminate rules, the particular composition of the disciplinary authorities and the limits of judicial review. This raises a problem in terms of compatibility of the phenomenon with the constitutional order.
Mobile health applications designed for self-management of chronic pulmonary diseases in children and adolescents: a systematic mapping review
Authors: Sapouna1,2 Vaia , Kitixis1 Pavlos , Petrou1 Elpiniki , Michailidou1 Theano , Dalamarinis1 Panagiotis , Kortianou1 Eleni
Published: September 2023

Objective: Mobile health (mHealth) applications are scarce for children and adolescents with chronic pulmonary diseases (CPDs). This study aimed to map and describe the contents of the mHealth apps available for use in children and adolescents with CPDs. Methods: We performed a systematic mapping review of published scientific literature in PubMed, Scopus, and Cochrane Library by February of 2023, using relevant keywords. Inclusion criteria were as follows: children aged < 18 years with CPDs; and studies published in English on mHealth apps. Results: A total number of 353 studies were found, 9 of which met the inclusion criteria. These studies described seven mHealth apps for Android and iOS, designed either for asthma (n = 5) or for cystic fibrosis (n = 2). Five content areas were identified: education/information; pharmacological treatment; emergency; support; and non-pharmacological treatment. The studies (4, 2, and 3, respectively) showed consistent findings using qualitative, quantitative, and mixed methodologies. Conclusions: This mapping review provided a guided selection of the most appropriate mHealth apps for use in children and adolescents with CPDs based on the needs of each target population. However, these mHealth apps have limited capabilities to reinforce disease self-management and provide information related to treatment compliance.
Secondary AA-amyloidosis in pediatric and adult patients: classification, etiology, pathogenesis, diagnosis, treatment
Authors: Stepanova A. A. , Savenkova N. D.
Published: September 2023

The literature review summarizes information about the current nomenclature and classification of amyloidosis, the features of the etiology, pathogenesis, course, diagnosis and treatment of systemic secondary AA-amyloidosis in children and adult patients. Among the systemic forms of amyloidosis, secondary AA-amyloidosis accounts for 40–60 % of cases. The literature data on the features of the development of secondary AA-amyloidosis in familial Mediterranean fever (periodic illness) due to homozygous or heterozygous mutation of the MEFV gene in children are presented.