bluuebunny/crossref_metadata_2025 huggingface dataset:
El silencio y la palabra Merleau-Ponty, Derrida y los márgenes del lenguaje
Authors: Potestà Andrea
Published: April 2019

Resumen: El artículo pretende realizar una confrontación entre el modelo fenomenológico de Merleau-Ponty y la propuesta deconstructiva de Derrida acerca del tema del lenguaje y de la problemática genética. En Merleau-Ponty, la cuestión genética se vincula a la noción de cuerpo y a la expresividad precategorial de los gestos, en los que el silencio describe una dimensión opaca e inalcanzable temáticamente, pero originaria y decisiva para la mirada fenomenológica. Por otra parte, Derrida es un crítico muy radical de todo uso filosófico de un origen pleno, y por lo tanto también de la proyección de un silencio primitivo pretendida por Merleau-Ponty. Sin embargo, la noción de silencio de Merleau-Ponty no cumple cabalmente la función que Derrida le asigna, siendo siempre para Merleau-Ponty un espacio diacrónico y diferencial. El texto que sigue pretende mostrar los puntos de contactos y de distancias entre Merleau-Ponty y Derrida con respecto al tema del lenguaje en general, haciendo también hincapié sobre la cuestión de la literatura, a la que ambos filósofos se dedican ampliamente y a la que ambos pretenden extender las cuestiones evocadas, con el objeto de demostrar que en este ámbito los motivos de oposición entre los dos planteamientos se hacen efímeros.
Spatial-temporal evolution characteristics and influencing factors of county rural hollowing in Henan
Authors: Yang Menghao , Yao Zhihong , Cao Lianhai , Zhang Haipeng , Huang Jie
Published: April 2019

ABSTRACT: Taking Henan province as an example, the index system of rural hollowing was constructed from three aspects of economy, population and land. Using the entropy weight method, hollowing index method, spatial autocorrelation analysis and Geo detector, spatial-temporal evolution characteristics and influencing factors of county rural hollowing from 2000 to 2013 in Henan province were analyzed. Results showed that the gap of rural hollowing between counties in Henan province expanded first and then decrease, and the whole province was at the middle level of rural hollowing, so the development of rural hollowing in Henan province was stable and positive. Spatial variation characteristics of different degrees rural hollowing during 2000-2013 were obvious, and the overall spatial pattern was higher in the northwest-southeast direction and lower in the northeast-southwest direction. There was a strong spatial positive correlation in rural hollowing, and spatial agglomeration was slightly weakened; the number of counties in H-H and L-L agglomeration areas was large and its agglomeration characteristics were obvious; the H-L agglomeration areas started from zero with a small number and scattered distribution. Influence of different factors on rural hollowing was quite different, and the per capita homestead area, the proportion of secondary and tertiary industries, the investment in fixed assets and the per capita net income of farmers were the dominant factors.
Leaf area estimation of squash ‘Brasileirinha’ by leaf dimensions
Authors: Toebe Marcos , Souza Rafael Rodrigues de , Mello Anderson Chuquel , Melo Patrícia Jesus de , Segatto Alexandre , Castanha Ana Carla
Published: April 2019

ABSTRACT: The objectives of this work were estimate the leaf area of squash ‘Brasileirinha’ by linear dimensions of the leaves and check models available in the literature. An experiment was conducted in the 2015/16 sowing season. Were collected 500 leaves and in each one, were measured the length (L), width (W) and length×width product (LW) and determined the real leaf area (LA). Then, 400 leaves were separated to generate models of the leaf area (LA) as a function of linear dimension (L, W or LW) of squash. The remaining 100 leaves were used for the validation of models. A second experiment was conducted in the 2016/17 sowing season. Were collected 250 leaves, used only for the validation of the models of the first experiment. There is collinearity between L and W and, therefore, models using the LW product are not recommended. The model LA=0.5482W2 + 0.0680W (R²=0.9867) is adequate for leaf area estimation of squash ‘Brasileirinha’.
BONE TISSUE BEHAVIOR OF RATS WITH EXPERIMENTAL PERIODONTITIS SUBJECTED TO PHYSICAL EXERCISE
Authors: Bortolini Bruna Martinazzo , Rodrigues Pedro Henrique de Carli , Brandão Lidiane Ura Afonso , Luize Danielle Shima , Bertolini Gladson Ricardo Flor , Nassar Carlos Augusto , Nassar Patricia Oehlmeyer
Published: April 2019

ABSTRACT Introduction: It is possible that physical activity protects the periodontium by mitigating excessive inflammatory response of the individual. There is some evidence from longitudinal studies and a prospective study demonstrating that physically active adults have experienced a decrease in the risk of periodontitis. To date no study has jointly explored the relationship of physical activity and periodontitis using inflammatory biomarkers. Objective: In this regard, the objective was to assess the bone tissue behavior of rats with experimental periodontitis subjected to aquatic exercise. Methods: Twenty-four male Wistar rats were divided into four groups: 1) without periodontitis and without exercise (CS); 2) without periodontitis and with exercise (CE); 3) with periodontitis and without exercise (DPS); 4) with periodontitis and with exercise (DPE). The animals from groups CE and DPE had swimming sessions for four weeks and the DPS and DPE groups were subjected to ligature-induced periodontitis. After 30 days the animals were sacrificed, and had their right and left hemimandibles removed for radiographic and histological analysis. The data obtained were analyzed and evaluated through ANOVA and Tukey tests. Results: Bone loss in the animals from the DPE group was found to be significantly lower (61.7 ± 2.2; p <0.05) than in those from the DPS group (84.5 ± 1.2; p <0.05), while in terms of the number of osteoblasts (DPS=11.0 ± 1.4; DPE=10.7 ± 5.2) and osteocytes (DPS=17.3 ± 3.1; DPE=19.0 ± 4.4), there was no significant decrease (p <0.05) in the groups subjected to experimental periodontitis, regardless of physical exercise. Conclusion: Physical exercise was found to have a protective effect in relation to bone height and did not influence bone density. Level of evidence II; Therapeutic studies - investigation of treatment results.
Occurrence of tayras (Eira barbara Linnaeus, 1758) with anomalous coloration in Cerrado remnants in the state of São Paulo, Brazil
Authors: Scrich Vitória M. , Pônzio Marcella C. , Pasqualotto Nielson , Rodrigues Thiago F. , Paolino Roberta M. , Chiarello Adriano G.
Published: April 2019

Abstract: Coloration anomalies are mainly genetically-based disorders in which body pigmentation is either reduced (hypopigmentation) or produced in excess (melanism), in parts or the totality of the body. Cases of hypopigmentation have been documented in many neotropical mammals, including the tayra (Eira barbara Linnaeus, 1758). We expand the account of anomalous coloration occurrence presenting new registers of hypopigmented tayras in Brazil. Data was collected during a mammal survey carried out in three agricultural landscapes within the Cerrado domain in the northeast of the state of São Paulo. We obtained two kinds of records of hypopigmented tayras, one from direct sighting and the other from a camera-trap. We discuss the likely implications of this conspicuous coloration to tayras and highlight some possibilities of study.
HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters
Authors: Barbalho Sandra Maria , Tofano Ricardo José , Oliveira Marcela Bueno de , Quesada Karina Rodrigues , Barion Mariana Ricci , Akuri Marina Cristina , Oshiiwa Marie , Bechara Marcelo Dib
Published: April 2019

Abstract Background Dyslipidemias are associated with atherosclerosis and cardiovascular diseases. Recently, non-high-density lipoprotein cholesterol (non-HDL-c) has emerged as a new target for assessment and prediction of risk of cardiovascular disease (CVD) and is closely associated with atheroma plaque progression. Objectives To evaluate associations between HDL-c and non-HDL-c levels and anthropometric and biochemical parameters and with the Castelli risk indexes I and II. Methods 300 randomly selected people were subdivided into two groups: patients with normal values for non-HDL-c and patients with altered values for non-HDL-c. These parameters were analyzed for associations with glycemia, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), Castelli Index I (CI-I), Castelli Index II (CI-II), waist circumference (WC), body mass index (BMI) and presence of metabolic syndrome (MS). Results Glycemia, TC, TG, LDL-c, CI-I, CI-II, WC and BMI were all significantly different between subjects with normal and altered values of HDL-c and non-HDL-c. TC and WC both exhibited significantly higher values among patients with abnormal non-HDL-c when compared to patients with abnormal HDL-c. A significant difference was observed in occurrence of MS among patients with altered values of HDL-c and non-HDL-c. Conclusions Our results show that both HDL-c and non-HDL-c are associated with insulin resistance, dyslipidemia, atherogenic indices, and obesity. There is therefore a need for randomized clinical intervention trials examining the potential role of non-HDL-c as a possible primary therapeutic target.
Eosinophilic fasciitis: an atypical presentation of a rare disease
Authors: Cabral Catia , Novais António , Araujo David , Mosca Ana , Lages Ana , Knock Anna
Published: April 2019

SUMMARY Eosinophilic fasciitis, or Shulman's disease, is a rare disease of unknown etiology. It is characterized by peripheral eosinophilia, hypergammaglobulinemia, and high erythrocyte sedimentation rate. The diagnosis is confirmed by a deep biopsy of the skin. The first line of treatment is corticotherapy. We present a rare case of eosinophilic fasciitis in a 27-year-old woman with an atypical presentation with symmetrical peripheral edema and a Groove sign. The patient responded well to treatment with corticosteroids at high doses and, in this context, was associated with hydroxychloroquine and azathioprine. After two and a half years, peripheral eosinophilia had increased, and more of her skin had hardened. At that time, the therapy was modified to include corticoids, methotrexate, and penicillamine. It is of great importance to publicize these cases that allow us to gather experience and better treat our patients.
Id-1 expression in colorectal adenocarcinoma tissues and its clinical significance
Authors: Wu Xue-Liang , Wang Yuan-Yuan , Wang Li-Kun , Xue Jun , Yang Dong-Dong , Qu Ming , Wang Chen-Yu , Guo Fei , Yang Rui-Min , Liu Bo
Published: April 2019

SUMMARY BACKGROUND: This study aims to investigate the expression of Id-1 in human colorectal adenocarcinoma tissues and explore its correlation with the clinical pathological parameters of colorectal cancer. METHODS: The Id-1 mRNA and protein expression levels of 50 specimens of normal colorectal tissues and 50 specimens of colorectal adenocarcinoma tissues were detected using reverse-transcription polymerase chain reaction and western blot. Furthermore, Id-1 protein was detected using immunohistochemistry. The correlation between the expression of Id-1 and clinicopathologic features was analyzed. RESULTS: The mRNA expression level of Id-1 in colorectal adenocarcinoma tissues and normal colorectal tissues was 0.96 ± 0.03 vs. 0.20 ± 0.04, respectively; and the difference was statistically significant (P=0.011). Furthermore, Id-1 protein expression was higher in colorectal adenocarcinoma tissues than in normal colorectal tissues (0.82 ± 0.04 vs. 0.31 ± 0.02, P=0.020). In addition, the positive protein expression rate of Id-1 was higher in colorectal adenocarcinoma tissues than in normal colorectal tissues (72.00% vs. 24.00%, X2=23.431, P=0.000). The expression of Id-1 was correlated with the depth of tumor invasion, TNM stage, lymph node metastasis, vessel invasion, and liver metastasis (P<0.01). However, this expression was not correlated with tumor size and differentiation degrees (P>0.05). CONCLUSIONS: The high Id-1 expression in colorectal adenocarcinoma tissues play an important role in the process of cancer, and is expected to become a new tumor monitoring indicator for clinical diagnosis, treatment, and prognosis judgment.
The positive impact of physical activity on the reduction of anxiety scores: a pilot study
Authors: Alves Dalton Gonçalves Lima , Rocha Sílvia Gabrielli , Andrade Evandro Vitor , Mendes Augusto Zbonik , Cunha Ângelo Geraldo José
Published: April 2019

SUMMARY OBJECTIVES: To compare anxiety scores between physical activity practitioners and sedentary, men and women and to relate them to physical activity frequency and age. METHODS: In this cross-sectional study, a sample of 256 regular aerobic physical activity practitioners was compared to a sample of 256 sedentary individuals (control group). Anxiety scores were quantified by Anxiety Inventory Spielberger State-Trait (STAI). The scores of the groups were compared using the Student t-test and chi-square test for parametric and non-parametric data, respectively. The correlation between scores of different variables was performed using the Pearson test. RESULTS: There was a significant difference between the average anxiety scores (p <0.001) and the chi-square test proved there is a higher prevalence of severe anxiety (p <0.001) in the sedentary group. Age did not correlate with worse anxiety scores (p <0.05). Comparing by gender, women had a higher prevalence of intense anxiety. CONCLUSIONS: Individuals who engage in regular physical activity have lower levels of anxiety, and both sexes are benefited with the anxiolytic potential of physical activity. Therefore, this study proved that the Roman poet Juvenal was right, and his expression “Mens sana in corpore sano,” could also be interpreted in the opposite direction, i.e., a healthy body correlates with a healthy mind.
Uremic neuropathy: an overview of the current literature
Authors: Camargo Celeste Rodovalho Soares de , Schoueri Jean Henri Maselli , Alves Beatriz da Costa Aguiar , Veiga Glaucia R. L. da , Fonseca Fernando L. A. , Bacci Marcelo R.
Published: April 2019

SUMMARY INTRODUCTION: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy (UN) is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate. OBJECTIVES: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. METHODS: This is a literature review of articles published on PubMed over the last 10 years using “Uremic Neuropathy” as “Title/Abstract”. RESULTS: A total of nine articles that met the inclusion criteria were included. UN is a distal symmetric sensorimotor polyneuropathy that occurs due to the accumulation of uremic toxins associated with an oxidative stress-related free radical activity. Hyperkalemia is thought to play an important role in its pathophysiology. Diagnosis depends on nerve conduction studies, and treatment includes dialysis or renal transplant. CONCLUSION: Clinical presentations of UN are broad and non-specific; nonetheless, it is important to detect early changes in order to avoid its progression. The earlier UN is diagnosed and treated, the more successful are the clinical outcomes.
Analysis of phonological processes in the acquisition of complex onset in children with typical phonological development
Authors: Soares Maraísa Espíndola de Castro , Payão Luzia Miscow da Cruz , Oliveira Jr. Miguel
Published: April 2019

ABSTRACT Objective: description and analysis of the phonological processes in the acquisition of complex onset by children with typical phonological development in the age ranges of 3;0 and 5;11. Methods: thirty-one students of a public day-care center in Maceió-AL, having no auditory, cognitive, or motor impairment, participated in this study. The data were collected using the ABFW Child Language Test (WERTZNER, 2004); spontaneous speech was also collected. Inferential statistical analysis of the data was performed, and the phonological processes were analyzed in the production of complex onset. Results: we found evidence for late acquisition of this syllabic component in the age range of 5;0-5;11 for both types of complex onsets. In relation to the prevalence of phonological processes, a statistically significant difference was observed between the different processes, with a prevalence of the simplified phonological process for C1V, when taking the two types of complex onset into consideration; however, the 5-year age group, in which there was a prevalence of liquid substitution, was an exception. Conclusion: the most observed phonological processes in children's speech were: simplification of C1V and liquid substitution. These results will contribute to the selection of the lexicon for evaluation and treatment of cases of atypical development.
Stomatognathic system screening in preschoolers and its importance for the elaboration of an intervention program in health
Authors: Santos Isadora Diniz dos , Santos Jaqueline Carvalho dos , Oliveira Aline Cabral de , Guedes-Granzotti Raphaela Barroso , Baldrighi Sílvia Elaine Zuim de Moraes , César Carla Patrícia Hernandez Alves Ribeiro
Published: April 2019

ABSTRACT Purpose: to describe the results obtained in the stomatognathic system screening applied in preschoolers of the public and private school systems. Methods: a cross-sectional, observational study randomly which selected four preschools linked to the Diretoria Regional de Educação. Two municipalities were drawn, and the educational institutions located in the city Center were selected. After submission of the proposal to the secretaries, managers and family members, the consent was granted for the screening involving face structures, muscle tonus, teeth, occlusion, mobility, speech, breathing, chewing and swallowing, by means of a tested and standardized protocol for evaluation of the stomatognathic system in a synthesized way. The results were submitted to descriptive statistical analysis and the chi-square test, with a significance level of 5%. Results: a total of 218 preschoolers, aged between two and six years old, participated in the study. Most of the participants, regardless of the institution attended, presented normality of the aspects surveyed. However, when comparing preschool children results among the institutions, there were significant differences for facial symmetry, speech, swallowing (for students in public schools), structural aspects and muscle tonus (private schools). Conclusion: the results obtained allowed the differentiated planning of health promotion and preventive actions of orofacial myofunctional disorders for preschoolers of distinct institutional systems, determining the importance of epidemiological surveys in health promotion spaces.
A Prática Espinosana de uma Educação Menor
Authors: Oliveira Fernando Bonadia de
Published: April 2019

Resumo: O conceito de educação menor, proposto por Sílvio Gallo em trabalho publicado na Revista Educação & Realidade no ano de 2002, parte de um deslocamento do conceito de literatura menor, criado por Gilles Deleuze e Félix Guattari. O objetivo deste artigo é identificar Bento de Espinosa (1632-1677), no contexto do século XVII, à prática de certa espécie de educação menor. Tal identificação será construída por meio de um exame de alguns aspectos da biografia do filósofo e de elementos colhidos de sua obra. Demonstra-se que Espinosa, em sua atividade como professor, manteve uma forma de educar não institucionalizada, desterritorializada e rizomática, assim como define o conceito de educação menor.
Building Bridges and Borders with Deficit Thinking
Authors: Koyama Jill , Desjardin Suzanne
Published: April 2019

Abstract: In this paper, we look at a high school to college transition program intended to prepare Latinx youth living in Arizona, a southwestern US border state, to negotiate, if not cross, borders, including those associated with accessing college. Purposefully, we problematize the at-risk discourses that reify the nature of these border landscapes within neoliberal framings aimed at explaining educational patterns of Latinxs and that infuse the college bridge program we examine. We demonstrate that while the program provides social and cultural capital, as well as additional temporary academic supports that high school students need to navigate college-going processes, it is also embedded with deficit perspectives that frame Latinxs as at-risk because of their culture, ethnicity, and language, or conversely, disregard their heritage entirely. Finally, we offer recommendations for future research of bridge and transition programs. We argue for turning examinations upside down to resituate and reconsider, and potentially dismantle, the enactments of at-risk deficit thinking, which still undergird many programs aimed at mediating borders experienced by Latinxs in the US.
Developing Flexibility in Mental Calculation
Authors: Rathgeb-Schnierer Elisabeth , Green Michael G
Published: April 2019

Abstract: Flexibility in performing mental calculations has become an important focus for mathematics educators, with research surging over the past two decades. Contemporary research results lends strong support for the development of mental flexibility in elementary classrooms. This report focuses on three interrelated themes: (1) a model of mental calculation that allows the study of flexible solution processes; (2) a review of definitions of flexibility and summary of reported research; and (3) an examination of the prerequisites for promoting mental flexibility. The approach termed Zahlenblickschulung is introduced with examples of activities that encourage students to sort numerical problems and reason about the sorting.
The role of long-term psychodynamic psychotherapy in improving attachment patterns, defense styles, and alexithymia in patients with depressive/anxiety disorders
Authors: Khademi Mojgan , Hajiahmadi Mahmoud , Faramarzi Mahbobeh
Published: April 2019

Abstract Introduction Long-term psychodynamic psychotherapy (LTPP) emphasizes the centrality of intrapsychic and unconscious conflicts and their relation to development. Although there is evidence supporting the efficacy of LTPP in mental disorders, little research has been published on the efficacy of LTPP for depressive and anxiety disorders. Objective To examine whether patients with anxiety and depressive disorders demonstrate improvement in their attachment styles, defense styles, psychiatric symptoms, anxiety/depressive symptoms, and alexithymia with LTPP. Methods In this retrospective, descriptive study, the psychological outcomes of patients who were treated at the psychoanalytic clinic of Babol University of Medical Sciences were assessed. Fourteen patients diagnosed with depressive or anxiety disorder participated in the study of LTPP using the self-psychology approach. The Beck Depression Inventory II, Beck Anxiety Inventory, Adult Attachment Scale, 40-item Defense Style Questionnaire, and the 20-item Toronto Alexithymia Scale were administered at pre-treatment, post-treatment, and 6-month follow-up. Generalized estimating equations were used to analyze changes in psychological outcomes after each of the three assessments. Results The mean scores of depression and anxiety and secure attachment improved significantly after LTPP with self-psychology approach from baseline to post-treatment and follow-up. Also, the mean scores of neurotic and immature defenses, difﬁculty in identifying feelings, difﬁculty in describing feelings, externally oriented thinking, and total alexithymia scores decreased significantly from baseline to post-treatment and follow-up. Conclusion Symptoms of anxiety disorders, depressive disorders, insecure attachment styles, alexithymia, and neurotic/immature defense styles improved after the LTPP with self-psychology approach. Moreover, the improvements persisted at the 6-month follow-up.
Craving for heroin: difference between methadone maintenance therapy patients with and without ADHD
Authors: Coppola Maurizio , Sacchetto Giuseppe , Mondola Raffaella
Published: April 2019

Abstract Introduction Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder persisting in adulthood in 40-60% of cases. Clinical and neuroimaging studies suggest that patients affected by both drug addiction and ADHD show higher rates of craving for drug than patients without ADHD. We designed a pilot open-label study to investigate the effects of ADHD on craving for heroin in methadone maintenance therapy patients. Method Patients were recruited from outpatient facilities in an addiction treatment unit in the municipality of Alba, Italy. They were assessed using the Structured Clinical Interview for DSM-5 (SCID-5), the SCID-5 for Personality Disorders (SCID-5-PD), the Diagnostic Interview for Adult ADHD, second edition (DIVA 2.0), and the Clinical Opiate Withdrawal Scale (COWS). Categorical variables were examined using the chi-square test, and continuous variables, the t-test and Mann-Whitney’s U test for normally and non-normally distributed data, respectively. Data distribution was evaluated using Shapiro-Wilk’s test. Significance was set at p=0.05. Bonferroni correction was applied (0.0063) to avoid type I error. Results A total of 104 patients were included in the study: 14 affected by ADHD (13.5%) and 90 were not affected (86.5%). Patients with ADHD showed higher intensity of craving for heroin than patients without ADHD in the absence of withdrawal symptoms. Conclusion Drug addiction and ADHD share various neurobiological mechanisms that mutually influence the evolution of both disorders. In particular, dopamine dysfunction within various brain circuits may influence impulsivity levels, motivation, inhibitory control, executive functions, and behavior and, consequently, the intensity of craving.
Emotional intelligence and schizophrenia spectrum disorders: a critical review
Authors: Martins Fernanda de Marzio Pestana , Leite Keila Pereira , Trevizol Alisson Paulino , Noto Julio Ricardo de Souza , Brietzke Elisa
Published: April 2019

Abstract Introduction Emotional intelligence (EI) is a theoretical construct postulated by Mayer and Salovey to designate the ability to perceive, understand, use and manage emotions. The study of EI in schizophrenia offers new insights into the disorder’s cognitive and functional impacts. Objectives To comprehensively review studies analyzing EI impairment in schizophrenia spectrum disorders using standardized instruments. Methods Searches were run on MEDLINE/PubMed, Google Scholar, Cochrane, LILACS, Embase, ClinicalTrials.gov and SciELO databases. The only validated instrument used was the Multifactor Emotional Intelligence Scale (MSCEIT). Articles that used all branches of the MSCEIT to assess EI in schizophrenia spectrum disorders and healthy controls were included in the review. Results We found 30 articles on this topic. The studies analyzed showed a significant impairment of MSCEIT total score in patients with schizophrenia spectrum disorders when compared to healthy controls. In relation to the MSCEIT branches, understanding of emotions and management of emotions are the most impaired branches. Conclusion Since most studies are cross-sectional, it is not possible to establish a cause and effect relationship between EI deficits and schizophrenia spectrum disorders. Therefore, longitudinal studies are needed to establish a clearer relationship between these variables. By so doing, we may be able to intervene for prevention and management of these disorders, aiming at better quality of life for patients.
PERSONALIDADE E DESTINO: PEDRO NAVA, MÁRIO DE ANDRADE E A SOCIALIZAÇÃO DO MODERNISMO
Authors: Bittencourt Andre
Published: April 2019

Resumo O objetivo do artigo é discutir a hipótese de que o modernismo dos anos 1920 pode ser pensado sociologicamente como um tipo de específico de socialização. Com o intuito de trabalhar essa questão, mobiliza-se a correspondência ainda pouco explorada de Pedro Nava com Mário de Andrade, assim como uma parcela das cartas deste último com Carlos Drummond de Andrade trocadas naquela década. Além das questões mais exploradas pela crítica, como a importância de temas como o "abrasileiramento da linguagem", procura-se demonstrar como essas peças narrativas implicam simultaneamente a conscientização de um projeto coletivo e a modelagem de um tipo específico de "personalidade" capaz de enfrentar os desafios impostos pelas exigências de um processo profundo de renovação que então se propunha.
JEFFREY ALEXANDER AND THE DEVELOPMENT OF CULTURAL SOCIOLOGY
Authors: Jacobs Ronald N.
Published: April 2019

Abstract Alexander's work has had a major impact on cultural sociology and the development of sociological theory more generally. His work in cultural sociology provides a large and useful toolkit for sociologists interested in doing empirical work on meaning and society. His theory of the civil sphere provides a template for scholars interested in studying the processes by which society itself become an object of interpretation and evaluation. All of these intellectual contributions have been supported by a generous style of theoretical practice, which combines solidarity, ritual, and a commitment to a "hermeneutics of faith".
80 ANOS DE CIÊNCIAS SOCIAIS NA UFRJ: RELEMBRANDO O PIONEIRISMO DOS PROJETOS GRUPOS ECONÔMICOS (1962) E TRABALHADORES CARIOCAS (1987)
Authors: Bôas Glaucia Villas
Published: April 2019

Resumo Na ocasião em que as ciências sociais completam 80 anos de existência na UFRJ, este artigo comemora dois projetos de pesquisa pioneiros, realçando tanto sua repercussão nos debates sobre os temas do capital e do trabalho quanto seus efeitos na construção institucional das ciências sociais no Rio de Janeiro. A primeira dessas pesquisas, realizada no Instituto de Ciências Sociais na década de 1960, sob a coordenação de Maurício Vinhas de Queiroz, identificou pela primeira vez os grupos econômicos brasileiros e estrangeiros instalados no país; a segunda, sob a coordenação de Alice Rangel de Paiva Abreu e Elina Gonçalves da Fonte Pessanha, com início no final de 1980, revelou características do protagonismo político dos trabalhadores e da participação do Estado em grandes empresas além de abordar questões de gênero e juventude.
JEFFREY C. ALEXANDER ON THE THEATRICALITY OF SOCIAL LIFE: DEEPENING THE HERMENEUTICS OF CULTURAL SOCIOLOGY
Authors: Côté Jean-François
Published: April 2019

Abstract This article provides a critical examination of the cultural sociology developed by Jeffrey C. Alexander, focusing on his view of the theatricality of social life. The argument is that, while Alexander’s perspective do engage in a highly significant valuation of the performative dimension of social and political life that matches his strong program in cultural sociology to add a reflexive turn to cultural production in general, his views on theatre and politics remain somehow limited in their efforts at reaching the symbolic structures that are constitutive of these domains. In using a structural hermeneutics to define the analytical core of his methodology, Alexander loses sight of a more dialectical hermeneutics able to tackle the significant transformations affecting those symbolic structures, and exhibited by both avant-garde theatre and media infused mass democratic politics.
BETWEEN THE SPIRIT AND THE LETTER: DURKHEIMIAN THEORY IN THE CULTURAL SOCIOLOGY OF JEFFREY ALEXANDER
Authors: Weiss Raquel
Published: April 2019

Abstract Émile Durkheim`s work forms the cornerstone of Alexander’s cultural sociology, to the point where it becomes virtually impossible to discern precisely where the process of reinterpretation stops and the construction of a new theory begins. In this article I aim to show the cardinal points of Alexander`s reading of Durkheim’s work, discussing how certain concepts and arguments are carefully selected in order to establish the bases of the strong program in cultural sociology, including in its ‘performative turn.’ In so doing, I highlight both strong and weak points in his reading of Durkheim’s texts, showing that there is an important expression of its ‘spirit’ even when he is not faithful to its ‘letter.’ In short, Alexander’s approach to Durkheim, a translation capable of actualizing its potentialities, purges his work of positivistic premises and adapts his theory to a comprehension of the social world, understood as a mesh of socially created and shared meanings.
A GRANDE ESPERANÇA: POLÍTICA AGRÁRIA NA CANÇÃO SERTANEJA DURANTE A DITADURA MILITAR (1964-1985)
Authors: Lima Marcela Elian
Published: April 2019

Resumo O artigo tem como objetivo analisar, no cancioneiro sertanejo produzido entre 1964 e 1985, imagens objetivas de esperança produzidas por seus compositores a partir das políticas agrárias executadas durante a ditadura militar. Ao compor essas imagens, o fizeram pela perspectiva dos liberais conservadores de direita, mas também pela maioria de seus ouvintes, os trabalhadores nas periferias ou nas roças. É a esperança que, nessas canções, convergiu diferentes concepções de reforma agrária em um impulso para a superação de um presente insatisfatório. Esse princípio ambíguo, capaz de provocar ilusões e firmar-se como o mais sério benefício para homens e mulheres, foi mobilizado no cancioneiro sertanejo para atribuir sentido a suas narrativas musicais sobre as transformações decorrentes da política agrária executada nesse período.
Reposição de próteses auditivas em programa de saúde auditiva
Authors: Ruschel Nathany Lima , Bonatto Amanda Somensi , Teixeira Adriane Ribeiro
Published: April 2019

RESUMO Objetivo Verificar os motivos e o tempo médio de reposição de próteses auditivas em usuários atendidos no sistema de alta complexidade em saúde auditiva, em um hospital no Sul do Brasil. Métodos Realizou-se consulta aos prontuários dos pacientes (crianças, adultos e idosos) que receberam próteses auditivas por meio do programa de saúde auditiva, no período de janeiro de 2010 a julho de 2017. Foi verificado o motivo da reposição, o número de reposições e o tempo de reposição para cada uma das orelhas. Os dados foram analisados de forma quantitativa, utilizando-se os testes qui-quadrado de Pearson ou exato de Fisher, com nível de significância de 0,05. Resultados Foram analisados 1.256 prontuários de crianças, adultos e idosos. O principal motivo de reposição foi por falha técnica. Nas crianças, o tempo médio da primeira reposição foi menor do que nos adultos e nos idosos. Adultos e idosos formaram o grupo que mais buscou o serviço para realização da primeira reposição de seus dispositivos. As crianças formaram o grupo que mais precisou da segunda e da terceira reposições. Conclusão Trezentos e quarenta e dois pacientes necessitaram repor, no mínimo uma vez, seus dispositivos, tendo como principal motivo a falha técnica. O tempo médio entre a adaptação e a primeira reposição foi de aproximadamente quatro anos.
Three-dimensional numerical simulation of flow in vertical slot fishways: validation of the model and characterization of the flow
Authors: Sanagiotto Daniela Guzzon , Rossi Júlia Brusso , Lauffer Luísa Lüdtke , Bravo Juan Martín
Published: April 2019

ABSTRACT Vertical slot fishways allow energy dissipation as a function of the pool, longitudinal slope, baffle and vertical slot design. The mean and turbulent flow patterns in these structures must be compatible with the fish target. The design of these structures is commonly based on previous successful fishways as well as simplified theoretical equations and empirical relationships. To aid in the design of these structures, a three-dimensional hydrodynamic model was used to simulate the flow, and experimental studies were used to validate the model. The mean velocities, pressures and parameters indicative of turbulence were analyzed. The maximum flow velocities were up to 32% higher than the values obtained using a simplified theoretical equation. The evaluation of the volumetric dissipated power indicated that the mean value for the pool was lower than 150 W/m3; however, analysis of the spatial distribution showed that in some areas, the values can exceed 1000 W/m3. The results indicate that the numerical simulation was able to adequately represent the flow considering the computational cost involved. Accordingly, it can be used as a complementary tool for the design of new fishways and for the analysis of modifications in existing ones.
Agricultural zoning of climate risk for Physalis peruviana cultivation in Southeastern Brazil
Authors: Aparecido Lucas Eduardo de Oliveira , Batista Rafael Madureira , Moraes José Reinaldo da Silva Cabral de , Costa Cícero Teixeira Silva , Moraes-Oliveira Adriana Ferreira de
Published: April 2019

Abstract: The objective of this work was to elaborate the agricultural zoning of climatic risk (ZARC) for Physalis peruviana, through the thermal and water requirements of the crop in Southeastern Brazil. Air temperature (TAIR) and precipitation (PYEAR) data from 1,530 meteorological stations covering the entire region were used. Regions were considered climatically favorable to Physalis peruviana when TAIR was between 13 and 18ºC and PYEAR between 1,000 and 2,000 mm per year. Regions where TAIR was above 30ºC or less than 13ºC were considered inapt. Maps were created with this information and used to identify climatic characteristics and to establish the agricultural aptitude classes, termed apt, inapt, and marginal for the cultivation of Physalis peruviana. The Southeastern region of Brazil showed a thermal variation from 16.5 to 22.6°C and water amplitude from 800 to 2,800 mm. ZARC shows that 10% of Southeastern Brazil is climatically apt for the cultivation of Physalis peruviana, corresponding to the following regions of Brazilian states: central and southern Minas Gerais, western Rio de Janeiro and Espírito Santo, and eastern and southern São Paulo.
Biological control of fruit flies in Brazil
Authors: Paranhos Beatriz Jordão , Nava Dori Edson , Malavasi Aldo
Published: April 2019

Abstract: Fruit flies are the main pests of fruit growing in Brazil. They have been managed predominantly with the use of insecticides applied as cover spray and or/as toxic baits. Currently, the trend of management strategies is toward the adoption of methods that cause the lowest environmental impact in large areas. In this context, biological control is an excellent option to be used together with other management strategies, such as sterile insects, because it leaves no residues, does not disturb nontarget pests, and can be permanent if the natural enemy establishes itself in the field. This review paper addresses the current knowledge on the biological control of fruit flies in Brazil, highlighting the great biodiversity of its natural enemies, especially parasitoids, its biology and ecology. The classical biological control programs in Brazil are also reported, from the introduction of Tetrastichus giffardianus (Hymenoptera: Eulophidae), in 1937, to control Ceratitis capitata (Diptera: Tephritidae), to that of Fopius arisanus (Hymenoptera: Braconidae), in 2012, to control Bactrocera carambolae (Diptera: Tephritidae). Finally, the obtained advances are pointed out, as well as the main bottlenecks and perspectives for the effective use of biological control programs against fruit flies.
Community structure of invertebrate fauna in Central Chilean Rivers
Authors: Ríos Patricio De los , Díaz Gustavo , Gonzalez Jorge , Górski Konrad , Habit Evelyn
Published: April 2019

Abstract Aim River systems of Central Chile are short, steep and fast flowing. They are characterized by discharge regimes dominated by rainfall and snowmelt. Invertebrate fauna is highly endemic. This study aimed to describe the community structure of invertebrate in eight river systems in Central Chile (33-39°S) using species co-occurrence and niche sharing null models. Methods Invertebrate samples were collected from Central Chilean rivers (33-39°S), data were analyzed co-occurrence species and niche sharing null models for determine potential structuring patterns. Results The results revealed the presence of non-structured patterns in co-occurrence considering each site as well as all sites, that is most probably an effect of presence of many repeated species in the studied sites. Furthermore, we found the existence of niche overlap due to interspecific competition at each site and among all sites. The results obtained from these river systems corroborate observations from Chilean Patagonian Rivers. Conclusion This study contributes to understanding of biogeographical and ecological patterns of invertebrate communities in central Chilean Rivers and provide foundations for more complex ecological studies.
“How Long Have I Got?”—A Prospective Cohort Study Comparing Validated Prognostic Factors for Use in Patients with Advanced Cancer
Authors: Simmons Claribel , McMillan Donald C. , Tuck Sharon , Graham Cat , McKeown Alistair , Bennett Mike , O'Neill Claire , Wilcock Andrew , Usborne Caroline , Fearon Kenneth C. , Fallon Marie , Laird Barry J. ,   on behalf of the IPAC Study Group
Published: April 2019

Background

The optimal prognostic factors in patients with advanced cancer are not known, as a comparison of these is lacking. The aim of the present study was to determine the optimal prognostic factors by comparing validated factors.

Materials and Methods

A multicenter, prospective observational cohort study recruited patients over 18 years with advanced cancer. The following were assessed: clinician-predicted survival (CPS), Eastern Cooperative Oncology Group performance status (ECOG-PS), patient reported outcome measures (anorexia, cognitive impairment, dyspnea, global health), metastatic disease, weight loss, modified Glasgow Prognostic Score (mGPS) based on C-reactive protein and albumin, lactate dehydrogenase (LDH), and white (WCC), neutrophil (NC), and lymphocyte cell counts. Survival at 1 and 3 months was assessed using area under the receiver operating curve and logistic regression analysis.

Results

Data were available on 478 patients, and the median survival was 4.27 (1.86–7.03) months. On univariate analysis, the following factors predicted death at 1 and 3 months: CPS, ECOG-PS, mGPS, WCC, NC (all p < .001), dyspnea, global health (both p ≤ .001), cognitive impairment, anorexia, LDH (all p < .01), and weight loss (p < .05). On multivariate analysis ECOG-PS, mGPS, and NC were independent predictors of survival at 1 and 3 months (all p < .01).

Conclusion

The simple combination of ECOG-PS and mGPS is an important novel prognostic framework which can alert clinicians to patients with good performance status who are at increased risk of having a higher symptom burden and dying at 3 months. From the recent literature it is likely that this framework will also be useful in referral for early palliative care with 6–24 months survival.

Implications for Practice

This large cohort study examined all validated prognostic factors in a head-to-head comparison and demonstrated the superior prognostic value of the Eastern Cooperative Oncology Group performance status (ECOG-PS)/modified Glasgow Prognostic Score (mGPS) combination over other prognostic factors. This combination is simple, accurate, and also relates to quality of life. It may be useful in identifying patients who may benefit from early referral to palliative care. It is proposed ECOG-PS/mGPS as the new prognostic domain in patients with advanced cancer.
Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer
Authors: Sequist Lecia V. , Gray Jhanelle Elaine , Harb Wael A. , Lopez-Chavez Ariel , Doebele Robert C. , Modiano Manuel R. , Jackman David Michael , Baggstrom Maria Quintos , Atmaca Akin , Felip Enriqueta , Provencio Mariano , Cobo Manuel , Adiwijaya Bambang , Kuesters Geoffrey , Kamoun Walid S. , Andreas Karen , Pipas J. Marc , Santillana Sergio , Cho Byoung Chul , Park Keunchil , Shepherd Frances A.
Published: April 2019

Background

Seribantumab (MM-121) is a fully human IgG2 monoclonal antibody that binds to human epidermal growth factor receptor 3 (HER3/ErbB3) to block heregulin (HRG/NRG)-mediated ErbB3 signaling and induce receptor downregulation. This open-label, randomized phase 1/2 study evaluated safety and efficacy of seribantumab plus erlotinib in advanced non-small cell lung cancer (NSCLC). Here, we report the activity of seribantumab plus erlotinib, versus erlotinib alone, in patients with EGFR wild-type tumors and describe the potential predictive power of HRG.

Materials and Methods

Patients with EGFR wild-type NSCLC were assigned randomly to receive seribantumab + erlotinib or erlotinib alone. Patients underwent pretreatment core needle biopsy and archived tumor samples were collected to support prespecified biomarker analyses.

Results

One hundred twenty-nine patients received seribantumab + erlotinib (n = 85) or erlotinib alone (n = 44). Median estimated progression-free survival (PFS) in the unselected intent-to-treat (ITT) population was 8.1 and 7.7 weeks in the experimental and control arm, respectively (hazard ratio [HR], 0.822; 95% confidence interval [CI], 0.37–1.828; p = 0.63), and median estimated overall survival was 27.3 and 40.3 weeks in the experimental and control arm, respectively (HR, 1.395; 95% CI, 0.846 to 2.301; p = .1898) In patients whose tumors had detectable HRG mRNA expression, treatment benefit was observed in the seribantumab + erlotinib combination (HR, 0.35; 95% CI, 0.16–0.76; p = .008). In contrast, in patients whose tumors were HRG negative, the HR was 2.15 (95% CI, 0.97–4.76; p = .059, HRG-by-treatment interaction, p value = .0016).

Conclusion

The addition of seribantumab to erlotinib did not result in improved PFS in unselected patients. However, predefined retrospective exploratory analyses suggest that detectable HRG mRNA levels identified patients who might benefit from seribantumab. An ongoing clinical trial of seribantumab, in combination with docetaxel, is underway in patients with advanced NSCLC and high HRG mRNA expression (NCT02387216).
Uso de drogas por mulheres durante o período gestacional
Authors: Alves Maia Jair , Lima Rodrigues Alesandro , Rosa de Souza Denisa , Barbosa Figueiredo Mediã
Published: April 2019

Objetivo: Identificar as drogas mais utilizadas por gestantes. Método: Estudo transversal de caráter observacional, descritivo e exploratório, realizado com 30 gestantes em agosto e setembro de 2017. Resultados: Durante o período gestacional: 60% das mulheres consumiam álcool, 30% usavam cigarro, 6,7% utilizavam álcool e cigarro associados e 3,3% das gestantes usavam concomitantemente, álcool, cigarro, maconha, cocaína e crack. Conclusão: O álcool foi à substância química mais utilizada pelas gestantes, talvez pelo baixo custo das drogas lícitas e por ser socialmente aceito.
Hybridization-capture for nanopore sequencing v1
Authors: Lee Isac , Workman Rachael , Zhiyong Wang Josh , Timp Winston
Published: April 2019

Large-scale genomic anomalies – structural variations (SVs) – are pervasive in cancer. Due to the scale of the SVs and the repetitive nature of the sequences usually flanking them, they are difficult to measure with conventional short-read sequencing. The long reads possible with nanopore sequencing provide an alternative to advance the understanding of SVs. In this application note, we applied SureSelectXT to nanopore long read sequencing, enriching for CDKN2A and SMAD4 tumor suppressor genes, to improve the depth and variant calling accuracy of nanopore sequencing. This application note focuses on optimizing the SureSelectXT protocol to long-read sequencing and using open-source softwares nanopolish and sniffles to improve the base calling accuracy and detect single nucleotide variants (SNVs) and structural variants (SVs), demonstrating the utility of SureSelect system on third-generation long-read sequencing platforms.