bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Association between Drinking Water Habits and the Occurrence of Women Breast Cancer
Authors: Keren Yael , Magnezi Racheli , Carmon Moshe , Amitai Yona
Published: October 2020

Risk and protective factors for breast cancer (BC) include lifestyle, diet, reproduction, and others. Increased risk for colon cancer was linked with low water intake. The link between water consumption and BC was scarcely studied. We investigated the association between water and fluid consumption and the occurrence of BC in a retrospective case–control study in the Shaare Zedek Medical Center, Jerusalem, in 206 women aged 25–65 years (106 with newly diagnosed BC, and 100 controls). A food frequency questionnaire (FFQ), consumption of water, foods, and beverages, lifestyle, and other risk and protective factors were recorded. The age of women in both groups was comparable ((M ± SD) 52.7 ± 9.8 and 50.6 ± 11.4 years, respectively (p = 0.29)). Women with BC consumed 20.2% less water (M ± SD = 5.28 ± 4.2 and 6.62 ± 4.5 cups/day, respectively, p = 0.02) and 14% less total fluids than controls (M ± SD = 2095 ± 937 mL/day and 2431 ± 1087 mL/day, respectively, p = 0.018). Multiple stepwise logistic regression showed that the differences remained significant both for daily water consumption (p = 0.031, CI = 0.462–0.964) and for total daily liquid intake (p = 0.029, CI = 0.938–0.997). Low water and liquids intake as a risk factor for BC may be related to the younger age of our subjects. The effect of age on the potential role of water intake in decreasing BC risk should be investigated.
Adsorption Media for the Removal of Soluble Phosphorus from Subsurface Drainage Water
Authors: Hauda Jessica K. , Safferman Steven I. , Ghane Ehsan
Published: October 2020

Phosphorus (P) is a valuable, nonrenewable resource in agriculture promoting crop growth. P losses through surface runoff and subsurface drainage discharge beneath the root zone is a loss of investment. P entering surface water contributes to eutrophication of freshwater environments, impacting tourism, human health, environmental safety, and property values. Soluble P (SP) from subsurface drainage is nearly all bioavailable and is a significant contributor to freshwater eutrophication. The research objective was to select phosphorus sorbing media (PSM) best suited for removing SP from subsurface drainage discharge. From the preliminary research and literature, PSM with this potential were steel furnace slag (SFS) and a nano-engineered media (NEM). The PSM were evaluated using typical subsurface drainage P concentrations in column experiments, then with an economic analysis for a study site in Michigan. Both the SFS and generalized NEM (GNEM) removed soluble reactive phosphorus from 0.50 to below 0.05 mg/L in laboratory column experiments. The most cost-effective option from the study site was the use of the SFS, then disposing it each year, costing $906/hectare/year for the case study. GNEM that was regenerated onsite had a very similar cost. The most expensive option was the use of GNEM to remove P, including regeneration at the manufacturer, costing $1641/hectare/year. This study suggests that both SFS and NEM are both suited for treating drainage discharge. The use of SFS was more economical for the study site, but each site needs to be individually considered.
Feasibility of Participatory Theater Workshops to Increase Staff Awareness of and Readiness to Respond to Abuse in Health Care: A Qualitative Study of a Pilot Intervention Using Forum Play among Sri Lankan Health Care Providers
Authors: Infanti Jennifer J. , Zbikowski Anke , Wijewardene Kumudu , Swahnberg Katarina
Published: October 2020

Women globally experience mistreatment by health providers during childbirth. Researchers have identified strategies to counteract this type of abuse in health care, but few have been evaluated. We used a theater technique, Forum Play, in a brief training intervention to increase awareness of abuse in health care and promote taking action to reduce or prevent it. The intervention was implemented in four workshops with 50 participating physicians and nurses from three hospitals in Colombo, Sri Lanka. This article reports the views of 23 workshop participants who also took part in four focus group discussions on the acceptability and feasibility of the method. The participants reported that the intervention method stimulated dialogue and critical reflection and increased their awareness of the everyday nature of abuses experienced by patients. Participants appreciated the participatory format of Forum Play, which allowed them to re-enact scenarios they had experienced and rehearse realistic actions to improve patient care in these situations. Structural factors were reported as limitations to the effectiveness of the intervention, including under-developed systems for protecting patient rights and reporting health provider abuses. Nonetheless, the study indicates the acceptability and feasibility of a theater-based training intervention for reducing the mistreatment of patients by health care providers in Sri Lanka.
A Spatially Explicit Approach for Targeting Resource-Poor Smallholders to Improve Their Participation in Agribusiness: A Case of Nyando and Vihiga County in Western Kenya
Authors: Mathenge Mwehe , Sonneveld Ben G. J. S. , Broerse Jacqueline E. W.
Published: October 2020

The majority of smallholder farmers in Sub-Saharan Africa face myriad challenges to participating in agribusiness markets. However, how the spatially explicit factors interact to influence household decision choices at the local level is not well understood. This paper’s objective is to identify, map, and analyze spatial dependency and heterogeneity in factors that impede poor smallholders from participating in agribusiness markets. Using the researcher-administered survey questionnaires, we collected geo-referenced data from 392 households in Western Kenya. We used three spatial geostatistics methods in Geographic Information System to analyze data—Global Moran’s I, Cluster and Outliers Analysis, and geographically weighted regression. Results show that factors impeding smallholder farmers exhibited local spatial autocorrelation that was linked to the local context. We identified distinct local spatial clusters (hot spots and cold spots clusters) that were spatially and statistically significant. Results affirm that spatially explicit factors play a crucial role in influencing the farming decisions of smallholder households. The paper has demonstrated that geospatial analysis using geographically disaggregated data and methods could help in the identification of resource-poor households and neighborhoods. To improve poor smallholders’ participation in agribusiness, we recommend policymakers to design spatially targeted interventions that are embedded in the local context and informed by locally expressed needs.
Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling
Authors: Choi Junghwa , Sung Jee Young , Lee Saerom , Yoo Jungyoen , Rongo Christopher , Kim Yong-Nyun , Shim Jaegal
Published: October 2020

The epidermal growth factor receptor (EGFR) signaling is important for normal development, such as vulval development in Caenorhabditis elegans, and hyperactivation of the EGFR is often associated with cancer development. Our previous report demonstrated the multivulva (Muv) phenotype, a tumor model in C. elegans (jgIs25 strain) by engineering LET-23/EGFR with a TKI-resistant human EGFR T790-L858 mutant. Because Rab proteins regulate vesicle transport, which is important for receptor signaling, we screened the RNAi in the jgIs25 strain to find the Rabs critical for Muv formation. Herein, we show that rab-8 RNAi and the rab-8 (-/-) mutation effectively reduce Muv formation. We demonstrate that RABN-8, an ortholog of Rabin8, known as a GEF for Rab8, is also required for Muv formation by promoting the secretion of EGL-17/FGF from vulval precursor cells. In addition, FGFR inhibitors decreased Muv formation mediated by mutant EGFR. Our data suggest that Rab8 and Rabin8 mediate Muv formation through FGF secretion in the EGFR-TKI-resistant nematode model. Furthermore, FGFR-TKIs more effectively inhibit the growth of lung cancer cell lines in H1975 (EGFR T790M-L858R; EGFR-TKI-resistant) than H522 (wild-type EGFR) and H1650 (EGFR exon 19 deletion; EGFR-TKI-sensitive) cells, suggesting that FGFR-TKIs could be used to control cancers with EGFR-TKI-resistant mutations.
Irisin Gene Delivery Ameliorates Burn-Induced Sensory and Motor Neuropathy
Authors: Huang Shu-Hung , Yang Shih-Ming , Lo Jing-Jou , Wu Sheng-Hua , Tai Ming-Hong
Published: October 2020

Burn-related neuropathy is common and often involves pain, paresthesia, or muscle weakness. Irisin, an exercise-induced myokine after cleavage from its membrane precursor fibronectin type III domain-containing 5 (FNDC5), exhibits neuroprotective and anti-inflammatory activities. A rat model of third-degree burn on the right hind paw was used to investigate the therapeutic role of irisin/FNDC5. Rats received burn injury and were treated with intrathecal recombinant adenovirus containing the irisin sequence (Ad-irisin) at 3 weeks postburn. One week later, mechanical allodynia was examined. The expression of irisin in cerebrospinal fluid (CSF) was detected. Ipsilateral gastrocnemius muscle and lumbar spinal cord were also obtained for further investigation. Furthermore, the anti-apoptotic effect of recombinant irisin in SH-SY5Y cells was evaluated through tumor necrosis factor alpha (TNFα) stimulus to mimic burn injury. We noted intrathecal Ad-irisin attenuated pain sensitization and gastrocnemius muscle atrophy by modulating the level of irisin in CSF, and the expression of neuronal FNDC5/irisin and TNFα in the spinal cord. Ad-irisin also ameliorated neuronal apoptosis in both dorsal and ventral horns. Furthermore, recombinant irisin attenuated TNFα-induced SH-SY5Y cell apoptosis. In summary, irisin attenuated allodynia and muscle wasting by ameliorating neuroinflammation-induced neuronal apoptosis.
A Neural-Network-Based Approach to Chinese–Uyghur Organization Name Translation
Authors: Wumaier Aishan , Xu Cuiyun , Kadeer Zaokere , Liu Wenqi , Wang Yingbo , Haierla Xireaili , Maimaiti Maihemuti , Tian ShengWei , Saimaiti Alimu
Published: October 2020

The recognition and translation of organization names (ONs) is challenging due to the complex structures and high variability involved. ONs consist not only of common generic words but also names, rare words, abbreviations and business and industry jargon. ONs are a sub-class of named entity (NE) phrases, which convey key information in text. As such, the correct translation of ONs is critical for machine translation and cross-lingual information retrieval. The existing Chinese–Uyghur neural machine translation systems have performed poorly when applied to ON translation tasks. As there are no publicly available Chinese–Uyghur ON translation corpora, an ON translation corpus is developed here, which includes 191,641 ON translation pairs. A word segmentation approach involving characterization, tagged characterization, byte pair encoding (BPE) and syllabification is proposed here for ON translation tasks. A recurrent neural network (RNN) attention framework and transformer are adapted here for ON translation tasks with different sequence granularities. The experimental results indicate that the transformer model not only outperforms the RNN attention model but also benefits from the proposed word segmentation approach. In addition, a Chinese–Uyghur ON translation system is developed here to automatically generate new translation pairs. This work significantly improves Chinese–Uyghur ON translation and can be applied to improve Chinese–Uyghur machine translation and cross-lingual information retrieval. It can also easily be extended to other agglutinative languages.
Divergence in Gut Bacterial Community Among Life Stages of the Rainbow Stag Beetle Phalacrognathus muelleri (Coleptera: Lucanidae)
Authors: Wang Miaomiao , Xiang Xingjia , Wan Xia
Published: October 2020

Although stag beetles are popular saprophytic insects, there are few studies about their gut bacterial community. This study focused on the gut bacterial community structure of the rainbow stag beetle (i.e., Phalacrognathus muelleri) in its larvae (three instars) and adult stages, using high throughput sequencing (Illumina Miseq). Our aim was to compare the gut bacterial community structure among different life stages. The results revealed that bacterial alpha diversity increased from the 1st instar to the 3rd instar larvae. Adults showed the lowest gut bacterial alpha diversity. Bacterial community composition was significantly different between larvae and adults (p = 0.001), and 1st instar larvae (early instar) had significant differences with the 2nd (p= 0.007) and 3rd (p = 0.001) instar larvae (final instar). However, there was little difference in the bacterial community composition between the 2nd and 3rd instar larvae (p = 0.059). Our study demonstrated dramatic shifts in gut bacterial community structure between larvae and adults. Larvae fed on decaying wood and adults fed on beetle jelly, suggesting that diet is a crucial factor shaping the gut bacterial community structure. There were significant differences in bacterial community structure between early instar and final instars larvae, suggesting that certain life stages are associated with a defined gut bacterial community.
Bone Loss, Osteoporosis, and Fractures in Patients with Rheumatoid Arthritis: A Review
Authors: Fardellone Patrice , Salawati Emad , Le Monnier Laure , Goëb Vincent
Published: October 2020

Rheumatoid arthritis (RA) is often characterized by bone loss and fragility fractures and is a frequent comorbidity. Compared with a matched population, RA patients with fractures have more common risk factors of osteoporosis and fragility fractures but also risk factors resulting from the disease itself such as duration, intensity of the inflammation and disability, and cachexia. The inflammatory reaction in the synovium results in the production of numerous cytokines (interleukin-1, interleukin-6, tumor necrosis factor) that activate osteoclasts and mediate cartilage and bone destruction of the joints, but also have a systemic effect leading to generalized bone loss. Regular bone mineral density (BMD) measurement, fracture risk assessment using tools such as the FRAX algorithm, and vertebral fracture assessment (VFA) should be performed for early detection of osteoporosis and accurate treatment in RA patients.
Microbial Abundance and Enzyme Activity Patterns: Response to Changing Environmental Characteristics along a Transect in Kongsfjorden (Svalbard Islands)
Authors: Caruso Gabriella , Madonia Alice , Bonamano Simone , Miserocchi Stefano , Giglio Federico , Maimone Giovanna , Azzaro Filippo , Decembrini Franco , La Ferla Rosabruna , Piermattei Viviana , Piazzolla Daniele , Marcelli Marco , Azzaro Maurizio
Published: October 2020

Svalbard archipelago is experiencing the effects of climate changes (i.e., glaciers’ thickness reduction and glacier front retreat), but how ice melting affects water biogeochemistry is still unknown. Microbial communities often act as environmental sentinels, modulating their distribution and activity in response to environmental variability. To assess microbial response to climate warming, within the ARctic: present Climatic change and pAst extreme events (ARCA) project, a survey was carried out along a transect in Konsfjorden from off-shore stations towards the Kronebreen glacier. Total bacterial abundance and the fraction of actively respiring cells (labelled by cyanotetrazolium chloride, CTC), cultivable heterotrophic bacterial abundance, and extracellular enzymatic activities (leucine aminopeptidase (LAP), beta-glucosidase (GLU), and alkaline phosphatase (AP)) were measured. In addition, water temperature, salinity, dissolved oxygen, turbidity, total suspended matter (TSM), particulate and chromophoric dissolved organic matter (CDOM), chlorophyll-a (Chl-a), and inorganic compounds were determined, in order to evaluate whether variations in microbial abundance and metabolism were related with changes in environmental variables. Colder waters at surface (3.5–5 m) depths and increased turbidity, TSM, and inorganic compounds found at some hydrological stations close to the glacier were signals of ice melting. CDOM absorption slope values (275–295 nm) varied from 0.0077 to 0.0109 nm−1, and total bacterial cell count and cultivable heterotrophic bacterial abundance were in the order of 106 cells/mL and 103 colony forming units/mL, respectively. Enzymatic rates <1.78, 1.25, and 0.25 nmol/L/h were recorded for AP, LAP, and GLU, respectively. Inorganic compounds, TSM, and turbidity correlated inversely with temperature; AP was significantly related with CDOM absorption spectra and heterotrophic bacteria (r = 0.59, 0.71, p < 0.05); and LAP with Chl-a, Particulate Organic Carbon (POC) and Particulate Organic Nitrogen (PON) (0.97, 0.780, 0.734, p < 0.01), suggesting that fresh material from ice melting stimulated the metabolism of the cultivable fraction.
Real-Time Wave Excitation Forces Estimation: An Application on the ISWEC Device
Authors: Bonfanti Mauro , Hillis Andrew , Sirigu Sergej Antonello , Dafnakis Panagiotis , Bracco Giovanni , Mattiazzo Giuliana , Plummer Andrew
Published: October 2020

Optimal control strategies represent a widespread solution to increase the extracted energy of a Wave Energy Converter (WEC). The aim is to bring the WEC into resonance enhancing the produced power without compromising its reliability and durability. Most of the control algorithms proposed in literature require for the knowledge of the Wave Excitation Force (WEF) generated from the incoming wave field. In practice, WEFs are unknown, and an estimate must be used. This paper investigates the WEF estimation of a non-linear WEC. A model-based and a model-free approach are proposed. First, a Kalman Filter (KF) is implemented considering the WEC linear model and the WEF modelled as an unknown state to be estimated. Second, a feedforward Neural Network (NN) is applied to map the WEC dynamics to the WEF by training the network through a supervised learning algorithm. Both methods are tested for a wide range of irregular sea-states showing promising results in terms of estimation accuracy. Sensitivity and robustness analyses are performed to investigate the estimation error in presence of un-modelled phenomena, model errors and measurement noise.
Challenging a Global Land Surface Model in a Local Socio-Environmental System
Authors: Dahlin Kyla M. , Akanga Donald , Lombardozzi Danica L. , Reed David E. , Shirkey Gabriela , Lei Cheyenne , Abraha Michael , Chen Jiquan
Published: October 2020

Land surface models (LSMs) predict how terrestrial fluxes of carbon, water, and energy change with abiotic drivers to inform the other components of Earth system models. Here, we focus on a single human-dominated watershed in southwestern Michigan, USA. We compare multiple processes in a commonly used LSM, the Community Land Model (CLM), to observational data at the single grid cell scale. For model inputs, we show correlations (Pearson’s R) ranging from 0.46 to 0.81 for annual temperature and precipitation, but a substantial mismatch between land cover distributions and their changes over time, with CLM correctly representing total agricultural area, but assuming large areas of natural grasslands where forests grow in reality. For CLM processes (outputs), seasonal changes in leaf area index (LAI; phenology) do not track satellite estimates well, and peak LAI in CLM is nearly double the satellite record (5.1 versus 2.8). Estimates of greenness and productivity, however, are more similar between CLM and observations. Summer soil moisture tracks in timing but not magnitude. Land surface reflectance (albedo) shows significant positive correlations in the winter, but not in the summer. Looking forward, key areas for model improvement include land cover distribution estimates, phenology algorithms, summertime radiative transfer modelling, and plant stress responses.
A Developmental Disorder of Signed Language Production in a Native Deaf Signer of ASL
Authors: Quinto-Pozos David , Cooley Frances
Published: October 2020

Evidence for a Developmental Language Disorder (DLD) could surface with language processing/comprehension, language production, or a combination of both. Whereas, various studies have described cases of DLD in signing deaf children, there exist few detailed examples of deaf children who exhibit production issues in the absence of processing or comprehension challenges or motor deficits. We describe such a situation by detailing a case study of “Gregory”, a deaf native signer of American Sign Language (ASL). We adopt a detailed case-study methodology for obtaining information from Gregory’s family and school, which we combine with linguistic and non-linguistic data that we collected through one-on-one sessions with Gregory. The results provide evidence of persistent issues with language production (in particular, atypical articulation of some phonological aspects of signs), yet typical comprehension skills and unremarkable fine-motor motor skills. We also provide a snapshot of Gregory’s rich linguistic environment, which we speculate, may serve to attenuate his production deficit. The results of this study have implications for the provision of language services for signing deaf children in schools and also for language therapists. We propose that language therapists who are fluent in signed language be trained to work with signing children.
Factor Cluster Analysis of Qingdao Port Logistics Competitiveness
Authors: Xu Wei , Gong Xiaohan
Published: October 2020

In order to make clear the positioning of the port logistics competitiveness of Qingdao Port among the major coastal ports in China, recognize the development level and shortcomings of its own port, and promote the enhancement of its own port logistics competitiveness, this paper uses the factor analysis method and fuzzy equivalence relationship clustering method to select 17 evaluation indicators from the two dimensions at the port hardware level and software level, respectively. Based on the relevant index data of nine major coastal ports in China including Qingdao Port from 2019, this paper makes a comparative analysis on the competitiveness of Qingdao Port in major coastal port groups in China. The results reflect the differences in the competitiveness of port logistics, and find the weaknesses of Qingdao Port in the strength of the port logistics industry, port transport conditions, etc., so as to improve and enhance the competitiveness of port logistics, such as increasing the proportion of port fixed investment, and speeding up the adjustment of transport structure.
4,4-Bis(hydroxymethyl)-2-phenyl-2-oxazoline
Authors: Hajib Sara , Boukhssas Salaheddine , Aouine Younas , Alami Anouar , Faraj Hassane , Zouihri Hafid , El Bali Brahim , Lachkar Mohammed
Published: October 2020

The title compound, 4,4-bis(hydroxymethyl)-2-phenyl-2-oxazoline 2, a well-known substance, was resynthesized in high yields through a conventional method. The structure of compound 2 was characterized for the first time by a single-crystal X-ray structure determination. The compound was further established through NMR spectroscopy (1D and 2D). In the molecular packing, two molecules of 4,4-bis(hydroxymethyl)-2-phenyl-2-oxazoline interact through H-Bonds to define “dimers” in which phenyl groups interact especially using π…π contact.
Addressing H-Material Interaction in Fast Diffusion Materials—A Feasibility Study on a Complex Phase Steel
Authors: Massone Agustina , Manhard Armin , Drexler Andreas , Posch Christian , Ecker Werner , Maier-Kiener Verena , Kiener Daniel
Published: October 2020

Hydrogen embrittlement (HE) is one of the main limitations in the use of advanced high-strength steels in the automotive industry. To have a better understanding of the interaction between hydrogen (H) and a complex phase steel, an in-situ method with plasma charging was applied in order to provide continuous H supply during mechanical testing in order to avoid H outgassing. For such fast-H diffusion materials, only direct observation during in-situ charging allows for addressing H effects on materials. Different plasma charging conditions were analysed, yet there was not a pronounced effect on the mechanical properties. The H concentration was calculated while using a simple analytical model as well as a simulation approach, resulting in consistent low H values, below the critical concentration to produce embrittlement. However, the dimple size decreased in the presence of H and, with increasing charging time, the crack propagation rate increased. The rate dependence of flow properties of the material was also investigated, proving that the material has no strain rate sensitivity, which confirmed that the crack propagation rate increased due to H effects. Even though the H concentration was low in the experiments that are presented here, different technological alternatives can be implemented in order to increase the maximum solute concentration.
On the Impact of Substrate Uniform Mechanical Tension on the Graphene Electronic Structure
Authors: Katin Konstantin P. , Maslov Mikhail M. , Krylov Konstantin S. , Mur Vadim D.
Published: October 2020

Employing density functional theory calculations, we obtain the possibility of fine-tuning the bandgap in graphene deposited on the hexagonal boron nitride and graphitic carbon nitride substrates. We found that the graphene sheet located on these substrates possesses the semiconducting gap, and uniform biaxial mechanical deformation could provide its smooth fitting. Moreover, mechanical tension offers the ability to control the Dirac velocity in deposited graphene. We analyze the resonant scattering of charge carriers in states with zero total angular momentum using the effective two-dimensional radial Dirac equation. In particular, the dependence of the critical impurity charge on the uniform deformation of graphene on the boron nitride substrate is shown. It turned out that, under uniform stretching/compression, the critical charge decreases/increases monotonically. The elastic scattering phases of a hole by a supercritical impurity are calculated. It is found that the model of a uniform charge distribution over the small radius sphere gives sharper resonance when compared to the case of the ball of the same radius. Overall, resonant scattering by the impurity with the nearly critical charge is similar to the scattering by the potential with a low-permeable barrier in nonrelativistic quantum theory.
Treatment of Osseous Defects after Mandibular Third Molar Removal with a Resorbable Alloplastic Grafting Material: A Case Series with 1- to 2-Year Follow-Up
Authors: Leventis Minas , Tsetsenekou Efstathia , Kalyvas Demos
Published: October 2020

Mandibular third molar (M3) surgical extraction may cause periodontal complications on the distal aspect of the root of the adjacent mandibular second molar (M2). Patients older than 26 years with periodontal pathology on the distal surface of the M2 and a horizontal/mesioangular impacted M3 may benefit from bone regenerative therapy at the time of surgery. In this prospective case series, an alloplastic fully resorbable bone grafting material, consisting of beta-tricalcium phosphate (β-TCP) and calcium sulfate (CS), was used for the treatment of the osseous defects after the removal of horizontal or mesioangular M3s in 4 patients older than 26 years. On presentation, the main radiological finding in all patients, indicating periodontal pathology, was the absence of bone between the crown of the M3 and the distal surface of the root of the M2. To evaluate the treatment outcome, bone gain (BG) was assessed by recording the amount of bone defect (BD) at the time of surgical removal (T0) and at the time of final follow-up (T1) 1 or 2 years post-operatively. The healing in all cases was uneventful, with no complications associated with the use of the alloplastic grafting material. Clinical and radiological examination at T1 revealed that all extraction sites were adequately restored, with significant BG of 6.07 ± 0.28 mm. No residual pathological pockets on the distal surface of the M2 were detected. Pocket depth (PD) at T1 was 2 ± 0.71 mm. Within the limitations of this case series, the results suggest that β-TCP/CS can support new bone formation at M3 post-extraction sites where bone regeneration methods are indicated, thus reducing the risk of having persistent or developing new periodontal problems at the adjacent M2.
Metal Nanoparticles Formation from Nickel Hydroxide
Authors: Sidorova Elena N. , Dzidziguri Ella L. , Vinichenko Yulia P. , Ozherelkov Dmitriy Yu. , Shinkaryov Alexander S. , Gromov Alexander A. , Nalivaiko Anton Yu.
Published: October 2020

In this study, the mechanism of nickel nanoparticle formation from its hydroxide was analyzed. Metallic nickel nanoparticles were obtained through the hydroxide’s reduction under hydrogen. Nickel hydroxides were produced from nickel (II) nitrate hexahydrate and NaOH by deposition under various initial conditions. The influence of washing treatment on the dispersion of obtained nickel powders was studied. The washing procedure of precipitates was carried out by centrifugation, ultrasonic treatment, and decantation. X-ray diffractometry, transmission electron microscopy, low-temperature nitrogen adsorption, infrared spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy methods were used for nanoparticle characterization. Based on the resulting data, a model of the Ni(OH)2 aggregate structure after deposition was proposed. The number of nickel hydroxide particles required to form one nickel nanoparticle was estimated, and a model of its formation was proposed.
Mapping ESG Trends by Distant Supervision of Neural Language Models
Authors: Raman Natraj , Bang Grace , Nourbakhsh Armineh
Published: October 2020

The integration of Environmental, Social and Governance (ESG) considerations into business decisions and investment strategies have accelerated over the past few years. It is important to quantify the extent to which ESG-related conversations are carried out by companies so that their impact on business operations can be objectively assessed. However, profiling ESG language is challenging due to its multi-faceted nature and the lack of supervised datasets. This research study aims to detect historical trends in ESG discussions by analyzing the transcripts of corporate earning calls. The proposed solution exploits recent advances in neural language modeling to understand the linguistic structure in ESG discourse. In detail, firstly we develop a classification model that categorizes the relevance of a text sentence to ESG. A pre-trained language model is fine-tuned on a small corporate sustainability reports dataset for this purpose. The semantic knowledge encoded in this classification model is then leveraged by applying it to the sentences in the conference transcripts using a novel distant-supervision approach. Extensive empirical evaluations against various pretraining techniques demonstrate the efficacy of the proposed transfer learning framework. Our analysis indicates that in the last 5 years, nearly 15% of the discussions during earnings calls pertained to ESG, implying that ESG factors are integral to business strategy.
Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study
Authors: Abramavičius Silvijus , Venslauskas Mantas , Vaitkus Antanas , Gudžiūnas Vaidotas , Laucius Ovidijus , Stankevičius Edgaras
Published: October 2020

Background and objectives: tremor is an unintentional and rhythmic movement of any part of the body that is a typical symptom of Essential Tremor (ET). ET impairs the quality of life of patients and is treated with pharmacotherapy. We investigated the tremor reduction efficacy of an innovative vibrational medical device (IMD) in ET patients. Materials and Methods: we conducted a prospective, single-center, single-arm, pragmatic study in ET patients with an extended safety study to evaluate the efficacy and safety of the Vilim Ball—a local hand-arm vibration device that produces vibrations in the frequency range of 8–18 Hz and amplitude from 0 to 2 mm. The primary endpoint was the decrease in the power spectrum after device use. The secondary endpoints were safety outcomes. Results: In total, 17 patients with ET were included in the main study, and no patients withdrew from the main study. The tremor power spectrum (m2/s3 Hz) was lower after the device use, represented as the mean (standard deviation): 0.106 (0.221); median (Md) 0.009 with the interquartile range; IQR, 0.087 vs. 0.042 (0.078); Md = 0.009 with the IQR 0.012; Wilcoxon signed-rank test V = 123; and p = 0.027. Seven patients reported that vibrational therapy was not effective. Two patients reported an increase in tremor after using the device. In the extended safety study, we included 51 patients: 31 patients with ET and 20 with Parkinsonian tremor, where 48 patients reported an improvement in tremor symptoms and 49 in function. No serious adverse events were reported, while two patients in the Parkinsonian tremor group reported a lack of efficacy of the proposed medical device. Conclusions: the device reduces essential tremor in some patients and is safe to use in ET.
Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review
Authors: Gonzalez Suarez Maria L , Thongprayoon Charat , Hansrivijit Panupong , Kovvuru Karthik , Kanduri Swetha R , Aeddula Narothama R , Pivovarova Aleksandra I , Chewcharat Api , Bathini Tarun , Mao Michael A , Basu Arpita , Cheungpasitporn Wisit
Published: October 2020

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx). We aimed to assess the efficacy of different treatments for C3G recurrence after KTx. Methods: Databases (MEDLINE, EMBASE, and Cochrane Database) were searched from inception through 3 May, 2019. Studies were included that reported outcomes of adult KTx recipients with C3G. Effect estimates from individual studies were combined using the random-effects, generic inverse variance method of DerSimonian and Laird., The protocol for this meta-analysis is registered with PROSPERO (no. CRD42019125718). Results: Twelve studies (7 cohort studies and 5 case series) consisting of 122 KTx patients with C3G (73 C3 glomerulonephritis (C3GN) and 49 dense deposit disease (DDD)) were included. The pooled estimated rates of allograft loss among KTx patients with C3G were 33% (95% CI: 12–57%) after eculizumab, 42% (95% CI: 2–89%) after therapeutic plasma exchange (TPE), and 81% (95% CI: 50–100%) after rituximab. Subgroup analysis based on type of C3G was performed. Pooled estimated rates of allograft loss in C3GN KTx patients were 22% (95% CI: 5–46%) after eculizumab, 56% (95% CI: 6–100%) after TPE, and 70% (95% CI: 24–100%) after rituximab. Pooled estimated rates of allograft loss in DDD KTx patients were 53% (95% CI: 0–100%) after eculizumab. Data on allograft loss in DDD after TPE (1 case series, 0/2 (0%) allograft loss at 6 months) and rituximab (1 cohort, 3/3 (100%) allograft loss) were limited. Among 66 patients (38 C3GN, 28 DDD) who received no treatment (due to stable allograft function at presentation and/or clinical judgment of physicians), pooled estimated rates of allograft loss were 32% (95% CI: 7–64%) and 53% (95% CI: 28–77%) for C3GN and DDD, respectively. Among treated C3G patients, data on soluble membrane attack complex of complement (sMAC) were limited to patients treated with eculizumab (N = 7). 80% of patients with elevated sMAC before eculizumab responded to treatment. In addition, all patients who responded to eculizumab had normal sMAC levels after post-eculizumab. Conclusions: Our study suggests that the lowest incidence of allograft loss (33%) among KTX patients with C3G are those treated with eculizumab. Among those who received no treatment for C3G due to stable allograft function, there is a high incidence of allograft loss of 32% in C3GN and 53% in DDD. sMAC level may help to select good responders to eculizumab.
Nanocomposite Membranes for Liquid and Gas Separations from the Perspective of Nanostructure Dimensions
Authors: Goh Pei Sean , Wong Kar Chun , Ismail Ahmad Fauzi
Published: October 2020

One of the critical aspects in the design of nanocomposite membrane is the selection of a well-matched pair of nanomaterials and a polymer matrix that suits their intended application. By making use of the fascinating flexibility of nanoscale materials, the functionalities of the resultant nanocomposite membranes can be tailored. The unique features demonstrated by nanomaterials are closely related to their dimensions, hence a greater attention is deserved for this critical aspect. Recognizing the impressive research efforts devoted to fine-tuning the nanocomposite membranes for a broad range of applications including gas and liquid separation, this review intends to discuss the selection criteria of nanostructured materials from the perspective of their dimensions for the production of high-performing nanocomposite membranes. Based on their dimension classifications, an overview of the characteristics of nanomaterials used for the development of nanocomposite membranes is presented. The advantages and roles of these nanomaterials in advancing the performance of the resultant nanocomposite membranes for gas and liquid separation are reviewed. By highlighting the importance of dimensions of nanomaterials that account for their intriguing structural and physical properties, the potential of these nanomaterials in the development of nanocomposite membranes can be fully harnessed.
Human mecC-Carrying MRSA: Clinical Implications and Risk Factors
Authors: Lozano Carmen , Fernández-Fernández Rosa , Ruiz-Ripa Laura , Gómez Paula , Zarazaga Myriam , Torres Carmen
Published: October 2020

A new methicillin resistance gene, named mecC, was first described in 2011 in both humans and animals. Since then, this gene has been detected in different production and free-living animals and as an agent causing infections in some humans. The possible impact that these isolates can have in clinical settings remains unknown. The current available information about mecC-carrying methicillin resistant S. aureus (MRSA) isolates obtained from human samples was analyzed in order to establish its possible clinical implications as well as to determine the infection types associated with this resistance mechanism, the characteristics of these mecC-carrying isolates, their possible relation with animals and the presence of other risk factors. Until now, most human mecC-MRSA infections have been reported in Europe and mecC-MRSA isolates have been identified belonging to a small number of clonal complexes. Although the prevalence of mecC-MRSA human infections is very low and isolates usually contain few resistance (except for beta-lactams) and virulence genes, first isolates harboring important virulence genes or that are resistant to non-beta lactams have already been described. Moreover, severe and even fatal human infection cases have been detected. mecC-carrying MRSA should be taken into consideration in hospital, veterinary and food safety laboratories and in prevention strategies in order to avoid possible emerging health problems.
Correction: Krauss, J., et al. Epichloë Endophyte Infection Rates and Alkaloid Content in Commercially Available Grass Seed Mixtures in Europe. Microorganisms 2020, 8, 498
Authors: Krauss Jochen , Vikuk Veronika , Young Carolyn A. , Krischke Markus , Mueller Martin J. , Baerenfaller Katja
Published: October 2020

The authors wish to make the following correction to this paper [...]
Screening Fungal Endophytes Derived from Under-Explored Egyptian Marine Habitats for Antimicrobial and Antioxidant Properties in Factionalised Textiles
Authors: Hamed Ahmed A. , Soldatou Sylvia , Qader M. Mallique , Arjunan Subha , Miranda Kevin Jace , Casolari Federica , Pavesi Coralie , Diyaolu Oluwatofunmilay A. , Thissera Bathini , Eshelli Manal , Belbahri Lassaad , Luptakova Lenka , Ibrahim Nabil A. , Abdel-Aziz Mohamed S. , Eid Basma M. , Ghareeb Mosad A. , Rateb Mostafa E. , Ebel Rainer
Published: October 2020

Marine endophytic fungi from under-explored locations are a promising source for the discovery of new bioactivities. Different endophytic fungi were isolated from plants and marine organisms collected from Wadi El-Natrun saline lakes and the Red Sea near Hurghada, Egypt. The isolated strains were grown on three different media, and their ethyl acetate crude extracts were evaluated for their antimicrobial activity against a panel of pathogenic bacteria and fungi as well as their antioxidant properties. Results showed that most of the 32 fungal isolates initially obtained possessed antimicrobial and antioxidant activities. The most potent antimicrobial extracts were applied to three different cellulose containing fabrics to add new multifunctional properties such as ultraviolet protection and antimicrobial functionality. For textile safety, the toxicity profile of the selected fungal extract was evaluated on human fibroblasts. The 21 strains displaying bioactivity were identified on molecular basis and selected for chemical screening and dereplication, which was carried out by analysis of the MS/MS data using the Global Natural Products Social Molecular Networking (GNPS) platform. The obtained molecular network revealed molecular families of compounds commonly produced by fungal strains, and in combination with manual dereplication, further previously reported metabolites were identified as well as potentially new derivatives.
Salt Marsh Elevation Drives Root Microbial Composition of the Native Invasive Grass Elytrigia atherica
Authors: Hernández Edisa García , Baraza Elena , Smit Christian , Berg Matty P. , Falcão Salles Joana
Published: October 2020

Elytrigia atherica is a native invasive plant species whose expansion on salt marshes is attributed to genotypic and phenotypic adaptations to non-ideal environmental conditions, forming two ecotypes. It is unknown how E. atherica–microbiome interactions are contributing to its adaptation. Here we investigated the effect of sea-water flooding frequency and associated soil (a)biotic conditions on plant traits and root-associated microbial community composition and potential functions of two E. atherica ecotypes. We observed higher endomycorrhizal colonization in high-elevation ecotypes (HE, low inundation frequency), whereas low-elevation ecotypes (LE, high inundation frequency) had higher specific leaf area. Similarly, rhizosphere and endosphere bacterial communities grouped according to ecotypes. Soil ammonium content and elevation explained rhizosphere bacterial composition. Around 60% the endosphere amplicon sequence variants (ASVs) were also found in soil and around 30% of the ASVs were ecotype-specific. The endosphere of HE-ecotype harbored more unique sequences than the LE-ecotype, the latter being abundant in halophylic bacterial species. The composition of the endosphere may explain salinity and drought tolerance in relation to the local environmental needs of each ecotype. Overall, these results suggest that E. atherica is flexible in its association with soil bacteria and ecotype-specific dissimilar, which may enhance its competitive strength in salt marshes.
Non-Invasive Luciferase Imaging of Type I Interferon Induction in a Transgenic Mouse Model of Biomaterial Associated Bacterial Infections: Microbial Specificity and Inter-Bacterial Species Interactions
Authors: Rahim Muhammad Imran , Winkel Andreas , Lienenklaus Stefan , Stumpp Nico S. , Szafrański Szymon P. , Kommerein Nadine , Willbold Elmar , Reifenrath Janin , Mueller Peter P. , Eisenburger Michael , Stiesch Meike
Published: October 2020

The performance of biomaterials is often compromised by bacterial infections and subsequent inflammation. So far, the conventional analysis of inflammatory processes in vivo involves time-consuming histology and biochemical assays. The present study employed a mouse model where interferon beta (IFN-β) is monitored as a marker for non-invasive rapid detection of inflammation in implant-related infections. The mouse model comprises subcutaneous implantation of morphologically modified titanium, followed by experimental infections with four taxonomically diverse oral bacteria: Streptococcus oralis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola (as mono culture or selected mixed-culture). IFN-β expression increased upon infections depending on the type of pathogen and was prolonged by the presence of the implant. IFN-β expression kinetics reduced with two mixed species infections when compared with the single species. Histological and confocal microscopy confirmed pathogen-specific infiltration of inflammatory cells at the implant-tissue interface. This was observed mainly in the vicinity of infected implants and was, in contrast to interferon expression, higher in infections with dual species. In summary, this non-invasive mouse model can be used to quantify longitudinally host inflammation in real time and suggests that the polymicrobial character of infection, highly relevant to clinical situations, has complex effects on host immunity.
The Influence of Fly Ash on Mechanical Properties of Clay-Based Ceramics
Authors: Húlan Tomáš , Štubňa Igor , Ondruška Ján , Trník Anton
Published: October 2020

Elastic properties of mixtures of illitic clay, thermal power plant fly ash (fluidized fly ash—FFA and pulverized fly ash—PFA), and grog were investigated during the heating and cooling stages of the firing. The grog part in the mixtures was replaced with 10, 20, 30, and 40 mass% of the fly ash, respectively. The temperature dependence of Young’s modulus was derived using the dynamical thermomechanical analysis, in which dimensions and mass determined from thermogravimeric and thermodilatometric results were used. Flexural strength was measured at the room temperature using the three-point bending test. The following results were obtained: (1) Bulk density showed a decreasing trend up to 900 °C and a steep increase above 900 °C. During cooling, the bulk density slightly increased down to the room temperature. (2) Young’s modulus increased significantly during heating up to ~300 °C. Dehydroxylation was almost not reflected in Young’s modulus. At temperatures higher than 800 °C, Young’s modulus began to increase due to sintering. (3) During cooling, down to the glass transformation, Young’s modulus slightly increased and then began to slightly decrease due to microcracking between phases with different thermal expansion coefficients. (4) Around the β→α quartz transition, radial stresses on the quartz grain altered from compressive to tensile, creating microcracks. Below 560 °C, the radial stress remained tensile, and consequently, the microcracking around the quartz grains and a decreasing Young’s modulus continued. (5) With a lower amount of PFA and FFA, a higher Young’s modulus was reached after sintering. The final values of Young’s modulus, measured after firing, show a decreasing trend and depend linearly on the part of fly ash. (6) The flexural strength measured after firing decreased linearly with the amount of the fly ash for both mixtures.