bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Experience with Dual Therapy in Multi-Experienced Patients. COMBINE Study
Authors: RC de Abreu , F Duarte
Published: August 2024

Introduction: Dual Antiretroviral Therapy (DT) has been evaluated as a successful treatment approach in various patient populations, including treatment-naïve and suppressed individuals. However, its effectiveness in experienced patients who become nonadherent due to pill burden, dosing frequency, and/or associated toxicities and develop resistance to it is uncertain. Objectives and Methods: This study aimed to assess the therapeutic efficacy of DT involving dolutegravir (DTG), doravirine (DOR), and darunavir/ cobicistat (DRV/c) or darunavir/ritonavir (DRV/r 600/100 bid) in multi-experienced patients, both suppressed and unsuppressed. For patients experiencing treatment failure, genotypic resistance testing was conducted to evaluate drug efficacy. In cases without treatment failure, regimen selection was based on considerations such as previous toxicities, drug interactions, and clinical history. Results: A total of 72 multi-experienced patients were studied (one with more than one treatment) between 2015 and 2023, mostly men (64%), with ages between 37 and 73 (average 54 ± 9) and a time of infection between 4 and 24 years (median or mean 16 ± 5). The major risk for infection was heterosexual (63%), followed by intravenous drug users (23%). All of them presented with more than one therapeutic drug class resistance, and the most previously used regime was RAL+LPV/R in 18 patients (24%). The most frequent reason for switching was the development of resistance in 30 (41%) of the patients, followed by simplification of the number of doses or tablets in 31 (42%) patients. At the switch, DTG+DRV/c were used in 46 (62%) patients, followed by DTG+DRV/R 600 in 19 (26%) patients. At the end of follow-up, 82% had a viral load of less than 200 cps/mL, 79% less than 100 cps/mL, and 67% had complete viral suppression. Twelve patients were lost for follow-up; seven patients were off medications; and of these, three died with AIDS-defining illnesses. Four additional patients died of non-HIV-related causes, all virally suppressed. Conclusion: The extended evaluation period (6 years) demonstrated that the simplification for dual therapy in patients who were treatment experienced with prior adherence failure with consequent multi-resistant drug patterns is associated with a high degree of efficacy (82%). Many (18%) still dropped out, consistent with findings from other studies. The reduction of pill burden and toxicities are factors that, by promoting a higher adherence rate to treatment, may have contributed to this success.
DEVELOPMENT OF THE SYSTEM OF ECOLOGICAL MONITORING OF THE ATMOSPHERE USING NEURAL NETWORK CAPABILITIES
Authors: Kulakova Ekaterina S. ,   Ufa State Petroleum Technological University (Branch in Sterlitamak), Batyrkaeva Asel M. ,   Ufa State Petroleum Technological University
Published: August 2024

Relevance The work is a description of the development of a system of environmental monitoring of the atmosphere with the possibility of using an artificial neural network to make predictions of concentrations of substances at different altitudes. The study considers the basic principles of neural networks functioning and their integration into the environmental monitoring system. Aim of research Aim of research is to consider the creation of a system for controlling the state of the atmosphere using the predictive capabilities of a neural network. The study will consider what problems can be solved using neural networks, what data are needed to train the model, and what advantages and disadvantages this approach has. Research methods The stages of environmental monitoring system development include the selection of real-time data acquisition, processing and display system (SCADA-system), collection of training data, selection of neural network development environment, determination of its architecture, performance evaluation, and integration of SCADA-system with neural network through database management system platform. Results The process of collecting data on the state of atmospheric air, displaying them in the system is described, and the work of neural network for predicting the level of atmospheric pollution at the height above sea level set by the operator is demonstrated. The article emphasizes the effectiveness of using neural network in environmental monitoring due to its ability to process large amounts of data and identify complex dependencies. The presented research results confirm the significance of using modern technologies, such as neural networks, to improve the accuracy and efficiency of environmental monitoring systems.
IDENTIFICATION OF THE CONDITION OF 110(35)/10 kV POWER TRANSFORMERS BASED ON THERMOGRAPHIC SURVEY DATA ANALYSIS AND ARTIFICIAL INTELLIGENCE METHODS
Authors: Sukhachev Ilya S. ,   Industrial University of Tyumen, Shelomentsev Vladislav A. , Khmara Guzel A. , Sidorov Sergei V. , Popov Evgeniy I. , Shvetsova Alena А. ,   Industrial University of Tyumen,   Industrial University of Tyumen,   Industrial University of Tyumen,   Industrial University of Tyumen,   ESKM AK CORPORATION LLC
Published: August 2024

Relevance At present, power systems are experiencing rapid development and increasing complexity in their structure due to the integration of new technological entities — consumers of electrical energy and associated functional nodes of the electrical network. The reliability of these components is assessed in accordance with the Ministry of Energy Order No. 676 dated July 26, 2017, based on technical condition indicators, encompassing 1234 parameters. Power transformers, being among the most common and critical functional nodes in the power system, are evaluated based on 243 parameters, a significant portion of which are obtained through thermal and visual inspection methods. The adoption of automated systems for monitoring diagnostic parameters of the technical condition of power transformers and the development of intelligent systems for processing the results of physical measurements can minimize the detection errors of defects and malfunctions in electrical equipment and transition to risk-oriented management. Thus, it is advisable to develop a system for identifying the technical condition of high-voltage leads of power transformers, as these nodes are most susceptible to damage. Aim of research Ensuring the stability of power systems through the development of a power transformer condition identification system based on thermographic data analysis and artificial intelligence algorithms, and subsequent transition to risk-oriented management in power engineering. Research methods Thermographic and visual inspection of high-voltage leads of power transformers; artificial intelligence methods: YOLO, ResNet, FEDOT, Random Forest; binary classification; performance metrics of the developed system; stress testing of the machine learning model. Results System for identifying condition of high-voltage leads of power transformers has been developed based on analysis of thermographic and visual inspection results using artificial intelligence methods. System has been evaluated by calculating its performance metrics: ROC AUC metric value indicates high accuracy in defect identification. When processing thermograms with defects, normalized ROC AUC metrics demonstrate system's resilience to various types of thermogram defects and its ability to maintain high efficiency under real-world conditions. System is capable of adapting to various data sources (thermograms, electrical load indicators, climatic conditions, etc.) and types of defects. It shows satisfactory results, even with small number of training records, which allows its use in situations with limited availability of initial data.
La voyelle nasale [ɔ̃] en FLE
Authors: Díez Abadie Gabriel
Published: August 2024

Cette étude explore les défis auxquels sont confrontés les apprenants hispanophones du français langue étrangère (FLE) dans la perception de la voyelle nasale [ɔ̃] et propose des stratégies de remédiation. Pour évaluer cette compétence, une étude de cas via un test de catégorisation libre a été menée avec des élèves du secondaire, divisés en un groupe expérimental et un groupe de contrôle. Au début, la performance moyenne était de 46%, indiquant une perception limitée. Cette faible performance initiale met en exergue des difficultés dans la distinction de mots ne différant que par la nasalisation. C'est dans ce contexte qu'un entraînement phonétique spécifique a été administré. À la suite de cette intervention, une augmentation significative à 75% dans la performance moyenne a été notée. Les résultats montrent que la position de [ɔ̃] dans les mots influence la perception, avec une meilleure reconnaissance quand la voyelle se trouve en position finale. Les résultats révèlent également une divergence dans les performances entre les groupes expérimental et contrôle, le premier montrant une amélioration prononcée. La conclusion souligne l'impact positif de l'entraînement phonétique sur la perception de [ɔ̃]. Cependant, les variations dans les résultats suggèrent un besoin de recherche supplémentaire pour comprendre les mécanismes sous-jacents. L'étude préconise une révision des méthodes pédagogiques, intégrant un entraînement phonétique intensif pour une maîtrise améliorée des nuances phonétiques du français. Ces résultats éclairent la voie vers l'amélioration des stratégies pédagogiques et encouragent des recherches plus approfondies pour affiner les interventions éducatives pour les apprenants hispanophones du FLE.
Agency and competency-based communicative pedagogy in secondary additional language teaching in Catalonia
Authors: Lagerwaard Hendrik Dirk
Published: August 2024

The LOMLOE (2020) and Decree 175/2022 establish the foundation for a competency-based approach that enhances the quality of learning in Catalonia. However, materializing such an approach in the additional language classroom can be challenging when theoretical concepts are to be concretized into tangible pedagogical actions. In view of this challenge, this study aims to design an agency and competency-based communicative pedagogical approach. This approach would be founded on the legal framework above and complemented by an agency-based conceptual framework and its accompanying pedagogical principles. The implementation and effects of the suggested approach is analyzed so as to understand how it promotes learners’ use of the additional language that is, in turn, driven through agency. A sociocultural psychology research methodology has been chosen and involves twenty students in compulsory secondary education in their fourth year in a school in Barcelona. For this study, interviews have been conducted and recordings have been taken based on virtual interactions. The interviews that focus on students’ perceptions of the pedagogical approach and how they felt during its implementation are examined through content analysis. The recordings from the students’ virtual interactions are analyzed for agentive behavior through agency-based classroom discourse analysis. The findings indicate that there are two main reasons as to why the new approach promotes agentive use of the additional language: a co-constructed trustful learning environment (Johnson & Golombek, 2016) and reflective action-oriented learning (Esteve, Fernández, Martín-Peris, & Atienza, 2017).
Glacier Changes and Fragmentation in Birahi Ganga Basin, Garhwal Himalaya: Implications for Water Resources
Authors: Mishra Aditya , Kumar Amit , Sain Kalachand , Verma Akshaya , Patidar Pawan
Published: August 2024

Glacier changes in the Himalaya are unequivocal under changing climate, making them susceptible to water availability in the future. Given the significance of glaciers for hydrology and the dangers they pose, the current study examines the state of the only glacier (i.e., Birahi Glacier) in the Birahi Ganga Catchment (BGC), Alaknanda Basin, Uttarakhand, from 1968 to 2020. It is observed that the glacier retreated 329 ± 15 m at an average rate of 6.3 ± 0.3 m a-1, and vacated an area of ~5000 m2 a-1 from 1968 to 2020. Based on satellite images, glacier separation began in 1994, as demonstrated by the small patches exposing the bedrock. It eventually grew and detached the lower debris cover zone from the upper clean ice zone in 2019. The recent satellite image reveals that snow and ice avalanches occasionally feed the lower, disconnected debris-covered portion. At present, the lower zone with an area of 0.59 ± 0.03 km2 behaves differently than the rest of the 3.6 ± 0.06 km2 clean glacier zone. Detachment of the glacier is attributed to topography; the steep slope along the glacier’s central flow line; the upward movement of the snowline and enhanced melting in the transition zone of debris-covered ice and clean ice. During the period between 1994-2020, the glacier shows pronounced shifting of snout elevation from ~3910 to ~4000 m asl (~90 m; 2.8 m a-1) and snowline from 5143 to 5335 m asl (192 ± 17 m; 7.3 ± 0.65 m a-1). Deglaciation in BGC may pose an alarming situation for water availability downstream for drinking, agriculture, and a hydroelectric power project in the future.
Uso de simuladores para educação em saúde de pessoas com diabetes: Uma revisão de escopo
Authors: Oliveira Maria Verônica Gomes de , Batista Graziela Silva , Silva Alex dos Santos , Matias Lucas David Maia , Gouveia Bernadete de Lourdes André , Brito Nathanielly Cristina Carvalho de , Andrade Lidiane Lima de
Published: August 2024

Objetivo: Mapear os simuladores usados como estratégia de educação em saúde para pessoas que vivem com diabetes mellitus. Método: Trata-se de uma revisão de escopo direcionada pelas recomendações do Instituto Joanna Briggs, realizada por meio de uma estratégia de pesquisa na literatura disponível nos bancos de dados PubMed Central, Web of Science, Scopus, ERIC, BDTD e RCAAP. A análise dos estudos identificados deu-se por dois revisores independentes. Os dados foram analisados de forma descritiva, levando à elaboração de quadros e estatísticas com frequência absoluta e relativa. Resultados: Foram identificados 226 estudos, dos quais nove compuseram a amostra final, levando à identificação do uso do Human Patient Simulator em 78% dos estudos, seguido por simulador de baixo custo e ferramenta de simulação (11% cada). Todas as estratégias apresentaram resultados positivos. Conclusão: Os simuladores produzidos são o Human Patient Simulator, simulador de baixo custo e ferramenta de simulação, com resultados igualmente satisfatórios.
Navigating early speech and swallowing challenges in progressive supranuclear palsy: A case study
Authors: Shabnam Srushti , Madhusudhanan Sneha , Udumbassery Nandana , Bhagavan Anushree
Published: August 2024

Progressive supranuclear palsy is a multisystem neurodegenerative disease which exhibits symptoms such as cognitive change, impaired balance, early falls, blurry or double vision, sleep difficulties, dysphagia, drooling, urinary urgency or incontinence, constipation, depression or anxiety, hyperphagia and change in food preferences, and weight loss.

The present case discusses the speech and swallowing issues in a 61-year-old male with progressive supranuclear palsy at early stage. Speech and swallowing observations revealed aspiration, hypophonia, difficulty swallowing, regurgitation episodes, and slurred speech. Followed by speech and swallowing assessment, the patient was diagnosed with Dysarthria with oropharyngeal dysphagia. T Syndopa Plus (1mg 1-1-1/day) was recommended by a neurologist. Diet modification and safe swallow strategies were suggested by speech language pathologist. Follow up after one month showed a significant improvement in swallowing skills and speech intelligibility.

The patient with progressive supranuclear palsy responds well to the T Syndopa- Plus (1mg 1-1-1/day) medication, diet modification and safe swallow strategies at an early stage of the disorder. The present case stresses on the importance of swallow related intervention at early stage.
UNA INTERESANTE COLECCION ETNOGRAFICA
Authors: Díaz-Piedrahita Santiago
Published: August 2024

Se da a conocer una importante colección de 12 acuarelas costumbristas de la autoría de Juan Francisco Mancera, pintor natural de Soatá, Boyacá, quien aprendió la técnica de la acuarela como dibujante de la Real Expedición Botánica del Nuevo Reino de Granada (1783 - 1816), empresa de la que se retiró en 1811. Se hacen comentarios relativos al origen del miniaturismo y la caricatura en Colombia, así como a la formación artística de Mancera, a la técnica por él empleada y a la composición y contenido de sus pinturas.
ALGUNOS PROBLEMAS ISOPERIMETRICOS
Authors: Escobar José F.
Published: August 2024

Se estudian la desigualdad isoperimétrica clásica, autovalores del Laplaciano y desigualdades de Sobolev en espacios curvilíneos, y las relaciones entre ellas.
UTILIZACION DE LAS MARIPOSAS COMO BIOINDICADORAS DEL TIPO DE HABITAT Y SU BIODIVERSIDAD EN COLOMBIA
Authors: Andrade-C M. Gonzalo
Published: August 2024

El estudio de las mariposas de Colombia en un rango altitudinal comprendido entre los 250 y los 3000 m de altitud, ha permitido describir la distribución local de la comunidad de mariposas en tres ecosistemas: Bosque primario (BP), Bosque secundario (BS) y Zonas perturbadas (ZP). Esta descripción se ha hecho con base en algunas condiciones de parámetros ambientales y gradientes, tales como: altitud, clima y condiciones de alteración de la vegetación. Simultáneamente, se ha descrito la estacionalidad de algunas especies, además de registra su actividad diurna y comparación de los datos de la vegetación propia de cada área.
DESCUBRIENDO ANCESTROS DE LOS UREDINALES
Authors: Buriticá C Pablo
Published: August 2024

Las especies de Uredinales de los géneros Uncol y Desmella, encontradas sobre helechos en el trópico bajo americano, exhiben características morfológicas, ciclos de vida y relaciones con sus hospederos que pueden considerarse ancestrales en comparación con otras especies que se desarrollan sobre helechos en regiones templadas. Estas últimas han sido tradicionalmente consideradas como el punto de partida de los fenómenos evolutivos en el orden Uredinales.
EL COMPORTAMIENTO DE ALGUNOS, ARTROPODOS COLOMBIANOS Y EUROPEOS Y SU SIGNIFICADO EVOLUTIVO
Authors: Sturm Helmut
Published: August 2024

Con base en observaciones directas, se comenta el comportamiento de varias especies de artrópodos, especialmente insectos. Se muestra como los insectos tropicales presentan actitudes muy interesantes, muchas veces únicas y que garantizan su supervivencia. De ello se infiere una interacción directa entre el comportamiento y la evolución.
LOS ELEMENTOS ORBITALES POSTNEWTONIANOS DE LA SOLUCIÓN ANALÍTICA DE DAMOUR & DERUELLE PARA EL PROBLEMA RELATIVISTA DE LOS DOS CUERPOS
Authors: Portilla José Gregorio , Tejeiro Juan Manuel
Published: August 2024

Se presenta una descripción detallada de la solución analítica propuesta por Damour & Deruelle (D&D) para resolver la ecuación diferencial que describe el problema de los dos cuerpos postnewtoniano. Se muestra la relación entre las constantes de movimiento y los denominados elementos orbitales postnewtonianos, los cuales se reducen a los elementos clásicos al tomar c ➔ ∞. Con el fin de verificar el grado de exactitud de la solución, se estudia el sistema conformado por Mercurio alrededor del Sol. Los resultados se han comparado con los obtenidos a través de una integración numérica directa de las ecuaciones de movimiento. Se encuentra que la solución analítica de D&D describe con un alto grado de exactitud el movimiento del Mercurio comparado con los resultados de la integración numérica directa de las ecuaciones diferenciales.
MODULAR SUMS OF SQUARES
Authors: Acosta Solarte Pablo A. , S. Albis Víctor
Published: August 2024

Se calcula el número de soluciones en [K[X]/(p(X)]s = L3 ; de las ecuaciones Qr(t1, . . . , ts) = α 1(zr)t 2/1 + ... + α ,( zr )t2/s = β(zr), de coeficientes en Lr  y se calcula la correspondiente serie de Poincaré.
AMBROSINOSTEROL: UN NUEVO Sα, 8α EPIDIOXIESTEROL CITOTÓXICO AISLADO DE LA ESPONJA MARINA AXINYSSA AMBROSIA
Authors: Petrichtcheva Natalia V. , Duque Carmenza , Fujimoto Yoshinori
Published: August 2024

Del extracto metanol-acetona (1:1) de la esponja marina Axinys sa ambrosia recolectada en el Caribe colombiano, se aisló e identificó una mezcla de 5α,8α-epidioxiesteroles con actividad citotóxica contra varias líneas de células cancerosas. Entre los epidioxiesteroles identificados sobresale por su concentración el 5α,8α-epidioxi-(24R)-metilcolesta-6,22-dien-3β-ol 6, seguido por el 5α,8α-epidioxi-[(24R)+(24S)]-etilcolesta-6,22-dien-3β-ol 7, 5α,8α-epidioxi-(22E,24S)-metilcolesta-6,22,25(27)-trien-3β-ol 2, 5α,8α-epidioxi-colesta-6,22-dien-3β-ol 3, 5α,8α-epidioxi-(22E,24R)-metilcolesta-6,9(11),22-trien-3β-ol 4 y el 5α,8α-epidioxi-(22E,24S)-etilcolesta-6,22,25(27)-trien-3β-ol 5. Es importante anotar que esta es la primera vez en la naturaleza que se aísla e identifica al 5α,8α-epidioxi-(22E,24S)-etilcolesta-6,22,25(27)-trien-3β-ol 5, ambrosinosterol, como compuesto de origen natural. Su estructura fue determinada por métodos espectroscópicos (IR, EM y RMN) y por síntesis de compuestos análogos. También se reportan por primera vez los datos espectroscópicos para el compuesto sintético (22E,24R)-etilcolesta-5,22,25-trien-3β-ol 8.
LAS GRAMÍNEAS EN COLOMBIA
Authors: Pinto-Escobar Polidoro
Published: August 2024

Se presenta una síntesis histórica de la familia Gramineae en el territorio de Colombia, acompañada de una reseña sobre morfología y fitogeografía de la misma.
MORFOLOGÍA DEL ANDROCEO, TAPETE Y ULTRAESTRUCTURA DEL POLEN DE SIPARUNA ASPERA (RUIZ & PAVÓN) A. DC. (SIPARUNACEAE)
Authors: Bello María Angélica , González Favio , Romero de Pérez Gloria
Published: August 2024

Las flores estaminadas, el androceo y el polen de Siparuna aspera (Siparunaceae) fueron estudiadas mediante el uso de microscopía de luz y electrónica. Se encontró por primera vez la presencia en Siparuna de estambres en tres verticilos, cada uno formado por dos estambres opuestos; los tres verticilos son decusados; a la vez, se detectó una estructura en el centro de la flor que parece ser un estilo vestigial. Se describe por primera vez la histología del tapete en Siparuna, el cual es secretor. El polen de la especie estudiada es globoso, inaperturado, y con exina diferenciada en sexina y nexina. La sexina posee un tectum ondulado, continuo, granular y delgado, y columnelas globoso-cónicas cuyos ápices atraviesan el tectum y forman una escultura equinada. La nexina es continua y se diferencia en una capa basal lamelar y una endexina granular. La intina es continua y con borde interno irregular. Todos estos caracteres sustentan una relación filogenética estrecha con Glossocalyx, sugerida también por datos moleculares. Debido a la ausencia de información y al conflicto en la interpretación de los caracteres florales y palinológicos de Siparunaceae y las familias relacionadas Atherospermataceae, Gomortegaceae, Hernandiaceae y Monimiaceae, se requieren más estudios detallados de la ontogenia floral, la ultraestructura del polen y la filogenia en estas familias, a fin de inferir la evolución de dichos caracteres, tan variables y extremos en el orden Laurales.
DILOCARCINUS LAEVIFRONS MOREIRA, 1901: A COMPLETE DESCRIPTION
Authors: Campos Martha R.
Published: August 2024

Dilocarcinus laevifrons Moreira, 1901, has been registered from Pernambuco (1901) and Amazon (1969) States, Brazil, but a complete description of the species was lacking. New records are here reported that expand the distribution of this species to the Colombian Amazon region, and the collected specimens permit a complete taxonomic description.
Feiras de ciências na educação infantil e anos iniciais do ensino fundamental: finalidades pedagógicas em discussão a partir da perspectiva de docentes da educação básica
Authors: Bertagna Maina , Lima Vilela Mariana
Published: August 2024

O artigo apresenta resultados parciais de uma pesquisa mais ampla que analisa finalidades pedagógicas de feiras de ciências escolares desenvolvidas no contexto de ações de extensão universitária em escolas do estado do Rio de Janeiro. Em abordagem qualitativa de pesquisa em educação, por meio de questionários, o estudo analisa a compreensão de uma professora da educação infantil e outra dos anos iniciais do ensino fundamental, cada uma atuante em uma escola, que definem as feiras de ciências como espaços de aprendizagem ativa e interdisciplinar, alfabetização científica, sentimentos de pertencimento, curiosidade, criticidade e interesse pela ciência. A partir dos resultados, discute-se a relevância pedagógica de tais atividades nas escolas, para além da formação científica dos estudantes.
Solid Lipid Nanoparticles for the Delivery of Plant-derived Bioactive Compounds in the Treatment of Cancer Disorders – A Review
Authors: Samanthula Kumara Swamy , Obbalareddy Satya , Thatipelli Ravi Chander , Bairi Agaiah Goud
Published: August 2024

Background: The study explores phyto-bioactive compounds in Solid Lipid Nanoparticles (SLN) and their potential use in cancer therapy. Objective: Most phyto-bioactive compounds have properties such as anti-inflammatory agents, antioxidants, anti-microbe agents, anti-arthritic agents, hypoglycemic agents, cardioprotective agents, and anti-cancer agents. Phyto-bioactive compounds are abundant in fruits, vegetables, and whole grains, and may impact metabolic processes improve health, and prevent illness. Breast, colon, and prostate cancers, as well as other malignancies, are now being studied for their potential prevention and treatment using therapies based on phyto-bioactive compounds in in vitro, in vivo, and clinical studies. Methods: More than 10 million individuals have lost their lives to cancer this year alone. Cancer is one of the most malignant and deadly diseases afflicting mankind today, and its death toll continues to rise. SLNs have been extensively used by several research groups to efficiently transport phyto-bioactive substances with enhanced anticancer effects. Now is the time for really groundbreaking ideas and innovations in the field of medicinal nanocarriers. Conclusion: Lipid nanoparticles’ size-dependent properties might lead to new therapeutics. Small size, large surface area, high drug loading, control pattern release, targeted drug release, and interface phase interaction are their benefits. Nanoformulations are undeniably powerful resources for therapeutic delivery applications; the current difficulty is in ensuring their safety, efficacy, and scalability for industrial production and eventual clinical use. Our review offers a novel perspective by focusing on the phyto-bioactive chemicals carried by these SLN nano-carriers, describing recent advancements and their potential applications to cancer therapy.
COMPARATIVE CHARACTERISTICS OF GUM REMODELING IN THE PROJECTION OF A DENTAL IMPLANT USING AN ALLOGRAFT MADE FROM A WIDE FASCIA OF THE HIP, AND AN AUTOGRAFT
Authors: Chekanova Anastasiya , Sel'skiy Natan , Musina Lyalya , Shimova Margarita
Published: August 2024

Currently, there is a growing scientific interest in the condition of the soft tissues surrounding dental implants and their impact on the long-term prognosis of implant treatment. Known risk factors for the development of peri-implantitis include deficiency or complete absence of attached keratinized gum in the implant area.
Various grafts are used to form a peri-implant “buffer” zone. When planning orthopedic structures on implants, the participation of a doctor – a dental surgeon and an orthopedist – is important.
However, there is still no consensus on the required volume of keratinized gum around dental implants. According to numerous authors, it has been shown that dental implants installed in mobile gums often lose epithelial attachment, which subsequently leads to the development of peri-implantitis. Other researchers believe that the absence.
There is an opinion that since dental implants with a rough surface are currently used in the vast majority of cases, a thickness of keratinized gum of no more than 2.0 mm is sufficient to form a peri-implant “buffer” zone. Moreover, in its distal sections the density of microvessels is greatest, in the middle sections it is the smallest, and in the frontal sections it occupies an intermediate position.
The paper provides an analysis of various methods of mucogingival surgery in the area of dental implants using an allogeneic graft from the fascia lata of the thigh of the Alloplant series.
CHARACTERISTICS OF COMPLICATIONS OF URANOPLASTY IN CHILDREN WITH CONGENITAL CLEFT PALATE
Authors: Chuykin Oleg , Bilak Anna , Kuchuk Kristina , Davletshin Nail' , Dyumeev Rustam , AKATYEVA Galina , Makusheva Natal'ya , Egorova Elena
Published: August 2024

Objectives. Reconstructive surgery to correct a congenital cleft palate is called uranoplasty. In the early postoperative period after uranoplasty, surgeons often encounter several problems: suture dehiscence, inflammation of the wound edges and the addition of a secondary infection to the wound process. The development of complications after uranoplasty is influenced by the general condition of the child, somatic and dental diseases. It is relevant and important to study the outcomes of uranoplasty in children with congenital cleft palate and evaluate the results for postoperative complications.
Purpose. To analyze the outcomes of uranoplasty in children with congenital cleft palate, to determine the frequency and types of postoperative complications.
Methodology. The article presents clinical examination data of 273 children with congenital cleft palate after uranoplasty over the past 5 years.
Results. In children aged 2–5 years with congenital cleft palate after uranoplasty, complications were noted in 19.78% of cases, among which velopharyngeal insufficiency was present in 44.44% of operated children, a short cicatricial palate was noted in 35.19% of children, perforated 20.37% of examined children have a palate defect.
Conclusions. After uranoplasty, complications arise as a result of the inflammatory process in the wound area. The standard protocol for patient management after uranoplasty involves the administration of an antibacterial drug intraoperatively. In order to increase the effectiveness of the prevention of postoperative complications after uranoplasty in children with congenital cleft palate, it is necessary to develop and implement therapeutic measures aimed at reducing the inflammatory process in the wound area and the formation of an elastic scar.
RATIONALE FOR THE PREVENTION OF DENTAL ANOMALIES AND EARLY ORTHODONTIC TREATMENT IN CHILDREN WITH HEARING LOSS AND COCHLEAR IMPLANTS
Authors: Chuykin Sergey , Savelyeva Elena , Speranskaya Natalya , SNETKOVA Tat`yana , AKATYEVA Galina , Makusheva Natal'ya , Chuykin Oleg
Published: August 2024

Subject. This paper highlights the relevance of prevention and early orthodontic treatment of dentoalveolar anomalies in children with hearing impairment, and the participation of an orthodontist in their comprehensive rehabilitation.
Purpose. To substantiate the need for the prevention of dental anomalies and early orthodontic treatment of children with hearing impairment and cochlear implants.
Methodology. The article presents the results of a dental examination of 78 schoolchildren aged 7–11 years with hearing impairment (including 11 people with cochlear implants) studying in specialized institutions. In this group of children, the frequency and types of dentoalveolar anomalies, indicators of the prevalence and intensity of dental caries (CFE + cf index), periodontal diseases (CPI index), soft tissue anomalies, oral hygiene (according to the simplified Green–Vermillion oral hygiene index) were determined, functional disorders of the dental system and risk factors for the formation of dental anomalies, the need for rehabilitation and orthodontic treatment.
Results. When conducting a dental examination of schoolchildren aged 7–11 years with hearing impairment, a high prevalence (94.8%) of dentoalveolar anomalies (94.8%), dental caries (96.2%), and periodontal diseases (42.3%) was established. The intensity of caries during the period of mixed dentition according to the index CFE + cf is 6.06. The Green–Vermillion index value is 2.6, which corresponds to a poor level of oral hygiene. A number of risk factors for the formation of dental anomalies have been identified: abnormalities of the soft tissues of the oral cavity, early removal of temporary teeth, unworn cusps of temporary teeth, myofunctional disorders in the maxillofacial area, bad habits.
Conclusions. The results of this study indicate a high prevalence and intensity of major dental diseases in schoolchildren with hearing impairment, including children with installed cochlear implants. The high need of the examined children for orthodontic treatment dictates the need to develop methods for the prevention and treatment of dental anomalies, adapted to this category of children.
ASSESSMENT OF ELECTROMYOGRAPHY INDICATORS OF THE MASTICTORY MUSCLES IN PATIENTS WITH PRESERVED DENTUTIONS WITHOUT TEMPOROMANDIBULAR JOINT PATHOLOGY
Authors: Voronina Ekaterina , Delec Aleksandr , Bobyleva Valeriya , Tezikov Dmitry
Published: August 2024

Introduction. Electromyography is a method of diagnosing the electrical potentials of skeletal muscles. It is used to study the normal and pathological function of the motor apparatus. Electromyographic examination of the masticatory and temporal muscles proper during a maximum compression test that simulates the state of the masticatory muscles and while maintaining their height is extremely common in many sources and is part of the basic diagnosis of temporomandibular joint dysfunction, which indicates the importance for researchers of this type of examination. Doctors orient themselves and adjust the treatment plan and tactics of their patients.
The aim of the study is to evaluate electromyography indicators in dental practice for diagnosing the condition of the temporomandibular joint.
Materials and Methods. During the experiment, 30 patients without pronounced clinical manifestations of temporomandibular joint dysfunction were selected. The removal of electromyography indicators (The complex of wireless monitoring of electrophysiological signals “Hummingbird” (Miograph, EMG)) was carried out.
Results. Over the course of five days, the patient's action potential of the studied muscles changed significantly, and the symmetry of the synergists' work also did not coincide. EMG activity in the chewing area differed during the experiment in the morning and evening at rest and during the Brooks test in all patients.
Conclusions. 1. The use of electromyography cannot be a fundamental method in diagnosing the temporomandibular joint due to the fact that muscle tone is not constant throughout the day.
2. A constant change in symmetry and absolute numbers during electromyography may indicate the high dynamism of the dental system, which is functionally connected with other systems, namely, involved as a compensatory mechanism in the pathogenesis of extra-articular pathologies of the temporomandibular joint.
FREQUENCY OF PRODUCTION OF ORTHOPEDIC CONSTRUCTIONS BASED ON METAL-FREE CERAMICS IN VOLGOGRAD AND REGION FOR 5 YEARS
Authors: Shulko Dmotry , Linchenko Irina , Strelkov Danila , Arakelyan Angelina , Zhosov Ruslan
Published: August 2024

The subject of the study is the analysis of statistical data on the frequency of manufacture of orthopedic structures based on metal-free ceramics in Volgograd and the region for 5 years in connection with their improved aesthetic performance compared to metal-ceramic structures.
The aim is to show the frequency of manufacturing orthopedic structures based on metal-free ceramics in Volgograd and the region over five years in order to reflect the dynamics of demand for them from patients.
Methodology. The study was conducted at the Department of Orthopedic Dentistry with the course of clinical Dentistry of VolgSMU with the assistance of the organizational and methodological department of the Volgograd Regional Clinical Dental Polyclinic. The data of the annual reports of orthopedic departments of dental clinics of the city and the region for a five-year period are systematized.
Results. Based on statistical data accumulated by the organizational and methodological department of the Volgograd Regional Clinical Dental Polyclinic State Autonomous Healthcare Institution (hereinafter referred to as the VOKSP State Medical Institution), the dynamics characterizing the frequency of manufacture of various metal-free structures in Volgograd and the region for the period from 2018 to 2022 is presented. In general, the frequency of manufacturing orthopedic structures based on metal-free ceramics in dental clinics in Volgograd and the region for five years in all groups had a positive trend, since the growth rate ranged from 194% (teeth in bridges) to 35% (artificial metal-free crowns).
Conclusions. The different frequency of manufacturing orthopedic metal-free structures was noted. The sharp reduction in the number of artificial crowns and bridges based on metal-free ceramics in 2020 was due to anti-epidemic measures caused by the COVID-19 pandemic. In five years, the frequency of manufacturing orthopedic metal-free structures in the Volgograd region has increased, which positively characterizes the demand for them from patients.
INFLUENCE OF BIOCHEMICAL FACTORS ON THE DURABILITY OF DENTAL IMPLANTS AND THE IMPORTANCE OF CONSIDERING THEM DURING OSSEOINTEGRATION
Authors: Kontomirov Kirill , Zimovskaya Angelina , Rogova Sofia , Rymar Nikita , Poleshchuk Tatyana
Published: August 2024

The subject of this article is a comprehensive analysis and evaluation of the various biochemical factors that influence the success of dental implant placement and function. The study aims are to identify and understand the following aspects: osseointegration processes, growth factors and cytokines, biocompatibility of materials and implants, ionic composition of the oral cavity, inflammatory processes, biochemical markers of recovery prediction.
The aim is to study and characterize the biochemical factors influencing the durability of the implant construction and the integrative ability of implants. Research objectives: 1) to determine which biochemical factors are most important for successful dental implantation and can be used as predictors of osseointegration success. 2) explain the importance for a comprehensive approach and to show the importance of integrating data on the biochemical status of the patient into the overall picture of preoperative examination and subsequent monitoring to improve the long-term results of implant treatment.
Methodology. A review of the literature on the subject for the last 10 years has been carried out, which allows to reveal correlations between biochemical processes and the success of dental implant surgeries. The mechanism of the impact of the biochemical composition of the oral cavity on the implant is considered.
Results. Literature data indicate that biochemical processes play a crucial role in the process of osseointegration and maintenance of stable connection of the implant with the bone tissue. Optimization of these processes can significantly improve the success of dental implants.
Conclusions. It was found that taking into account the biochemical factors influencing osseointegration, immune response and tissue reaction to implant materials helps to better understand the mechanisms related to implant biocompatibility with oral tissues for further successful implantation.
THE EFFECT OF POLARIZED POLYCHROMATIC RADIATION AND ANTIBACTERIAL THERAPY ON THE ACTIVITY OF NEUTROPHILIC LEUKOCYTES IN THE TREATMENT OF CHRONIC PERIODONTITIS
Authors: Garazha Sergey , Grishilova Elena , KHUBAYEV Zelimkhan , Dolgalev Aleksandr , IVASHOVA Alla , TAIMAZOVA Dilyara , NEKRASOVA Elizaveta
Published: August 2024

Subject. The subject of the study is the enzymatic activity of neutrophilic polymorphonuclear leukocytes in the treatment of chronic generalized periodontitis.
Objectives. To study the effect of polarized polychromatic radiation and antibacterial therapy on cytoenzymochemical indices of neutrophilic leukocyte activity in the treatment of moderate chronic generalized periodontitis.
Methodology. The study involved 80 patients of both sexes aged 20 to 59 years, who were divided into two groups. In the comparison group, treatment was carried out with the antimicrobial dental gel "Dentamet". In the main group, after antimicrobial treatment, piler therapy was carried out using polarized, incoherent, polychromatic radiation, the source of which was the physiotherapeutic device "Bioptron Pro-1". Neutrophil leukocyte activity was assessed by the level of cationic proteins, myeloperoxidase and alkaline phosphatase activity before treatment and in periods from three months to one year.
Results. During antimicrobial therapy, a decrease in the activity of neutrophil leukocytes was established within no more than three months of observation: the number of cationic proteins decreased by 1.98 times, myeloperoxidase activity decreased by 2.31 times, and alkaline phosphatase activity fell by 2.36 times (p = 0.0027). After six months, the activity of leukocytes in this group of patients did not differ significantly from the values obtained before treatment (p > 0.05). With consistent use of antimicrobial action and Piler therapy, a decrease in the activity of neutrophilic leukocytes, characteristic of remission of the inflammatory process, was established within six months: the amount of cationic proteins decreases by 2.15 times, the activity of myeloperoxidase decreases by 2.55 times, the activity of alkaline phosphatase falls by 2.56 times (p = 0.0455).
Conclusions. As a result of the treatment of chronic generalized periodontitis of moderate severity using antibacterial gel and polarized polychromatic radiation, a decrease in the activity of neutrophilic leukocytes (p < 0.05) was established, which persists for six months of observation.
EVALUATION OF DENTAL PARAMETERS OF THE QUALITY OF LIFE OF WOMEN WITH CHRONIC PERIODONTITIS AND DECREASED BONE MINERAL DENSITY DURING DYNAMIC OBSERVATION AND SUPPORTIVE THERAPY
Authors: Griroriev Sergey , Sablina Svetlana , Elovicova Tat'yana , Zakroeva Alla , Dominykh Maria , Dorokhina Ksenya , Krochalev Vadim
Published: August 2024

Subject. The subject of this study is the patients’ quality of life.
Objectives. The study aimed to evaluate dental parameters of the quality of life of women with chronic generalized periodontitis and decreased bone mineral density during dynamic observation and supportive therapy.
Methodology. The study was conducted by the Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases, the Department of Medical Physics and Digital Technologies. The study involved 76 women with chronic generalized periodontitis of moderate severity and decreased bone mineral density. The reference group comprised 33 conditionally healthy women. The patients with chronic generalized periodontitis of moderate severity and decreased bone mineral density were randomly divided into two subgroups with similar distributions by sex, age and clinical manifestations. The therapy was performed according to Clinical Practice Guidelines (protocols) for diagnosis code K05.31 using proprietary and conventional approaches. Index assessment consisted of DMFT, OHI-S, PMA, Ulitovsky’s efficiency index of treatment. The online survey questionnaire was used to assess the quality of life according to a valid oral health OHIP-49-RU scale (by O.S. Gileva et al., 2009).
Conclusions. The change in the quality of life is directly related to the degree of inflammatory destruction of periodontal tissue and assigned higher scores by women in all sections of the online survey according to Ʃ OHIP-49-RU questionnaire. Following periodontal therapy, for patients with chronic generalized periodontitis of moderate severity and decreased bone mineral density the effectiveness of therapy was apparently enhanced in the both groups. The quality of life (Ʃ OHIP-49-RU (%)) increased by 2.3 times during application of the proprietary treatment approach in the first subgroup N1 (proving a high anti-inflammatory potential of the proposed treatment approach) and by 1.9 times in the group subjected to conventional treatment (Ʃ OHIP-49-RU (%)).
Innovatory Methods in Policymaking: Introducing the Use of Verbatim Theatre
Authors: Ingram Charlie ,   Coventry University, UK, Whatley Sarah , Henry Nick , Foellmer Susanne ,   Coventry University, UK,   Coventry University, UK,   Coventry University, UK
Published: August 2024

This report introduces Headphone Verbatim Theatre (HVT), a method of data gathering that involves a performance created solely from the words spoken by interview participants. HVT responds to the challenges faced by policymakers around incorporating citizen experiences in policy design and evaluation. After identifying the problem policymakers currently face in capturing the voices of citizens, the report outlines the method of HVT and summarises its key benefits. Through embedded video clips, the report gives examples of where the method has been used and further, how dissemination in a live performance offers an effective and emotive connection between citizens and policy makers. In the final section it details the method’s operational requirements.
Dynamique et déterminants de la productivité totale du travail dans les pays d’Afrique subsaharienne
Authors: Igue Charlemagne B. , Essehou Yves
Published: August 2024

Objectif : Le but visé dans cet article est d’analyser la dynamique de la productivité totale du travail en examinant les déterminants de cette dernière en Afrique subsaharienne.
Conception/méthodologie/approche : Ce papier exploite la méthode de décomposition totale du travail et d’un modèle VECM structurel sur données de panels pour 40 pays d’ASS couvrant la période 1995 – 2019.
Résultats : Les résultats indiquent que les changements structurels, ont favorablement contribué (39,54%) à la croissance de la productivité totale du travail en ASS tandis que la productivité intra sectorielle a quant à elle ralentit la croissance de cette dernière (-48,12%). L’analyse sectorielle révèle une contribution négative pour l’agriculture ; positive pour le secteur manufacturier tandis que le secteur des services apparaît avec une contribution de 55,5% pour les changements structurels contre un apport négatif de la productivité intra sectorielle (-40,9%). Par ailleurs, les résultats du modèle VECM montrent que le taux brut de scolarisation secondaire, les technologies de l’information et de la communication, la stabilité politique et le contrôle de corruption favorisent significativement la productivité totale du travail en ASS.
Originalité/valeur : Ces résultats impliquent qu’il est nécessaire pour les pays Africain de réorienter la main-d’œuvre vers le secteur manufacturier et surtout celui des services à forte productivité pour capter l’excédent de main-d’œuvre venant de l’agriculture.
Analyse de la décomposition des inégalités dans l’utilisation des soins de santé maternelle au Togo
Authors: Tossou Yaovi
Published: August 2024

Objectif : L’objectif général de cette recherche est d’analyser l’inégalité dans l’utilisation des soins de santé maternelle au Togo.
Conception/méthodologie/approche : En se servant de la décomposition de l'indice de concentration, de la courbe de concentration et des données de l'enquête démographique de santé de 2013 (EDS III) au Togo.
Résultats : Les résultats révèlent que l'âge, le niveau d'éducation, la profession de la femme et le lieu de résidence sont les déterminants de l'utilisation des services de santé maternelle. Ainsi, les groupes d'âge de 15-20 ans et de 31-49 ans contribuent faiblement aux inégalités dans les besoins de services de santé, respectivement de -0,024 et de -0,022 chez les femmes.
Originalité/ valeur : Ces résultats suggèrent qu'il est nécessaire d'encourager des politiques essentielles visant à améliorer le niveau d'éducation des femmes et de l'indice de richesse afin de réduire le risque d'inégalité dans l'utilisation des soins de santé maternelle au Togo.