bluuebunny/crossref_metadata_2025 huggingface dataset:
TICs y promoción de corresponsabilidades masculinas en el cuidado de VIH e ITSs
Authors: García Darwin
Published: March 2022

El presente artículo nace del Proyecto de Vinculación con la Comunidad denominado: “Prevención y sensibilización en VIH/SIDA en colectivos clave del cantón Cuenca: población universitaria” auspiciado por la Universidad de Cuenca, a través de la carrera de Género y Desarrollo,  el mismo que se constituye en un trabajo de investigación que aglutina a una muestra de estudiantes de las doce facultades de esta casa de estudio, este proceso investigativo radica en hacer un despistaje de los conocimiento sobre infecciones de transmisión sexual (ITSs) y VIH/SIDA,  para sugerir estrategias de intervención educativa adecuadas a ser implementadas en los y las alumnas de la Universidad de Cuenca, proceso que parte desde la concepción adecuada de términos, hasta elementos que permitan desarrollar una adecuada conciencia sobre las relaciones afectivo-sexuales basadas en el autocuidado y la no violencia desde un enfoque de género, con énfasis en la prevención del VIH. Para este escrito, se toma en cuenta una de las áreas abordadas en dicho despistaje, que se relaciona con dos aspectos específicos, el primero orientado a cómo el grupo de estudiantes accede a la información relacionada con ITS/VIH, y el segundo a cómo las percepciones sobre cuidado y autocuidado son determinantes para la comprensión de las implicaciones que conlleva un adecuado sistema de prevención que parta del criterio personal como un acto sensible y responsable.
DETERMINAN KONSUMSI ENERGI NEGARA ANGGOTA ORGANISASI KERJASAMA ISLAM
Authors: Rahmandani Nadira , Sukmana Raditya
Published: March 2022

This study aims to determine the effect of economic growth, foreign direct investment, and trade openness on energy consumption in the Organization of Islamic Cooperation – OIC countries from 2004 until 2014 simultaneously and partially. The study uses a qualitative method and employs panel data regression to analyze. The sample is taken by applying a purposive sampling technique and obtained 38 OIC countries. The empirical result shows that economic growth, foreign direct investment, and trade openness are simultaneously significant affecting energy consumption. Partially, economic growth and foreign direct investment have positive and significant effect on energy consumption while trade openness have negative and not significant effect on energy consumption.Keywords: Energy consumption, economic growth, trade openness, OIC countriesREFFERENCESAnto, M.B. Hendrie. 2003. Pengantar ekonomika Mikro Islami. Yogyakarta: Ekonisia.Antonio, Muhammad Syafi’i. 2001. Bank Syari’ah dari Teori ke Praktik. Jakarta: Gema Insani.Biro Pusat Statistik (BPS). 2008. Perkembangan Nilai Tukar Petani dan Harga Produsen Gabah, (online), (www.bps.go.id/getfile.php?news=319) diakses 17 Agustus 2017Burhansyah, Rusli dan Melia P. 2010.Kinerja Usaha Tani Padi dan Indikator Kesejahteraan Petani di Kubu Raya Kalimantan Barat, (Online), (www.pse.litbang.deptan.go.id)/ind/pdffiles/Pros_MP_15_2010.pdf) diakses 17 Agustus 2017Ghazaly, Abdul Rahman, dkk. 2010. Fiqh Muamalat. Jakarta: Prenada Media Group.Haroen, Nasrun. 2007. Fiqh Muamalah. Jakarta: Gaya Media PratamaHasan, M. Ali. 20004. Berbagai Macam Transaksi dalam Islam (Fiqh Muamalat). Jakarta: PT. Raja Grafindo Persada.Heryawan, Ahmad. 2009. “Kesejahteraan dan Ukurannya”. (Online). (http://ahmadheryawan.blogspot.co.id/kesejahteraan-dan-ukurannya). Diakses pada 3 februari 2017.Munawir, Ahmad Warson. 1997. Kamus Indonesia-Arab-Inggris. Surabaya: Pustaka ProgresifNasikun. 1993. Sistem Sosial Indonesia. Jakarta: Raja Grafindo PersadaPusat Pengkajian dan Pengembangan Ekonomi Islam (P3EI). 2008. Ekonomi Islam. Jakarta: PT. Raja Grafindo Persada.Setiawan, Iwan. 2008. Alternatif Pemberdayaan Bagi Peningkatan Kesejahteraan Petani Lahan Kering (Studi Literatur Petani Jagung di Jawa Barat). Skripsi tidak diterbitkan. Bandung. Fakultas Pertanian Universitas Padjajaran.Sugiyono. 2010. Metode Penelitian Kuantitatif, Kualitatif, dan R&D. Bandung: Alfabeta.Syamsuddien, Darsyaf Ibnu. 1994. Darussalam: Prototype Negeri Yang Damai. Surabaya: Media Idaman Press.Yin, Robert K. 2009.Case Study Research Design and Methods.Fourth Edition. California: sage inc.
Research and Practice on the Practical Teaching System of Architecture Specialty in Local Universities Under the Background of Application-Oriented Talents Training
Authors: Tian Congxiang , Liu Xiancheng , Qin Zhiwei
Published: March 2022

With the continuous development of China's construction industry, China's demand for architectural professionals is increasing, which also promotes the great development of architectural education. In the practical teaching of architecture major in local universities, there are still some problems: classroom theory cannot be combined with practical courses, teaching mode is too single, teaching lacks flexibility and characteristics, teaching content lags behind, students have few opportunities to practice learning in society and enterprises, and their participation is not high. Through the reform and practice of practical teaching system, the characteristic architecture education of independent colleges is developed to improve the practical and hands-on design ability of architecture students.
Efektivitas Penyelesaian Perkara Secara E-Court di Pengadilan Agama Kabupaten Kediri
Authors: Khofifatus Salima Safira , Safudin Endrik
Published: March 2022

This study discusses about how the effectiveness of the e-court that runs in the Kediri Regency Religious Court. As it is understood that the e-court regulation was born because of the need for the easier, cheaper, and efficient services based on PERMA Number 1 of 2019. The formulation of the problem in this study is: How is the effectiveness of the implementation of e-court on the process of filing cases at the Religious Court of Kediri Regency, and What factors influence the implementation of e-court in the process of filing cases and e-litigation. To answer this question, the researcher uses a combination research method, where researchers can use data in the form of interviews (triangulation), and data analysis that is both deductive and inductive as well as a conceptual approach to the theory of effectiveness that will be brought by researchers in this study. From the results of this study, it can be concluded that the e-court that occurred at the Kediri Religious Court has fulfilled the effectiveness of the court in litigation. This can be seen from the fulfillment of a judicial process which is simpler, faster, and less expensive than the usual proceedings. With the existence of e-court litigation services, both justice seekers and courts can get better benefits than ordinary litigation.

Penelitian ini membahas tentang bagaimana keefektivitasan e-court yang berjalan di Pengadilan Agama Kabupaten Kediri. Sebagaimana dipahami bahwa regulasi e-court lahir karena kebutuhan pelayanan yang lebih mudah, murah, dan efisien berdasarkan PERMA Nomor 1 Tahun 2019. Rumusan masalah dalam penelitian ini adalah: Bagaimana efektivitas pelaksanaan e-court terhadap proses pengajuan perkara di Pengadilan Agama Kabupaten Kediri, dan Faktor-faktor apa yang berpengaruh terhadap pelaksanaan e-court di dalam proses pengajuan perkara dan e-litigasi. Untuk menjawab pertanyaan tersebut peneliti menggunakan metode penelitian kombinasi, dimana peneliti bisa menggunakan data baik berupa wawancara (triangulasi), dan analisis data yang bersifat deduktif maupun induktif serta pendekatan secara konseptual mengenai teori efektivitas yang akan dibawa peneliti didalam penelitian ini. Dari hasil penelitian ini dapat disimpulkan bahwa e-court yang terjadi di Pengadilan Agama Kediri sudah memenuhi keefektivitasan pengadilan dalam berperkara. Hal ini dapat dilihat dari terpenuhinya peradilan yang lebih sederhana, cepat, dan biaya ringan jika dibandingkan dengan proses beracara secara biasa. Dengan adanya layanan berperkara secara e-court, baik pihak pencari keadilan maupun pengadilan dapat memperoleh manfaat yang lebih baik daripada berperkara secara biasa.
Different AHO phenotype in a Chinese family with a novel GNAS missense mutation: a case report
Authors: ZOU Chao-Chun , Zhou Qing , Liang Bin , Fu Qing Xian , Liu Hui
Published: March 2022

BackgroundAlbright’s hereditary osteodystrophy (AHO) is an inherited disorder which is caused by an inactivating mutation in the GNAS gene. AHO appears in either pseudohypoparathyroidism 1a (PHP1a) when GNAS gene is maternally inherited or pseudo-pseudohypoparathyroidism (PPHP) when it is paternally inherited. Case presentationWe describe the clinical and biochemical characteristics of two patients, a boy and his mother, and identify a novel heterozygous missense variant c.1123G>T (p. Val375Leu) in the exon 13 of GNAS gene. The boy presented with typical AHO phenotype (early-onset obesity, round face, short neck, shortened fifth metacarpal bone, developmental retardation, but without short stature), multiple hormone resistance including PTH, TSH and ACTH, and mild calcification in the right basal ganglia. The mother only presented with brachydactyly and short stature, without hormone resistance and other signs of AHO. The diagnosis of PHP-1a for the son and PPHP for the mother were confirmed.Conclusion: This study further expands the spectrum of known GNAS mutations, and also demonstrates the heterogeneous phenotype of AHO due to a novel GNAS mutation.
Microstructure and mechanical properties of laser deposition manufactured a newly developed Ti-6Al-2Mo-2Sn-2Zr-2Cr-2V titanium alloy
Authors: Wang Chao , Yi Junzhen , Wang Jiaxing , Wu Jiabao , Shao Shuai , Qin Lanyun , Yang Guang
Published: March 2022

With the rapid development of aviation industry, the study of new type titanium alloy with superior mechanical properties is of great significance. In this paper, a newly developed Ti-6Al-2Mo-2Sn-2Zr-2Cr-2V (Ti-622222) alloy was fabricated by laser deposition manufacturing (LDM). The as-deposited Ti-622222 alloy exhibits coarse β columnar grains containing the basket-weave structure knitted with α phases and β phases. The solution and aging treatment decreases the size and content of primary α phase, but promotes the precipitation of secondary α phase. The microhardness shows a rising trend with the solution temperature increasing due to the precipitation of fine secondary α phase. The LDMed Ti-622222 alloy exhibits superior tensile strength (1025 MPa) and inferior elongation (6.0%). With the solution temperature increasing, the strength increases but the plasticity first increases and then decreases. The LDMed Ti-622222 alloy exhibits a mixed fracture mechanism of ductile and brittle fracture. The LDMed Ti-622222 alloy exhibits obvious anisotropy of impact property, the average impact toughness of the as-deposited sample in scanning direction is 23.4 J/cm2 lower than that (40.9 J/cm2) in deposition direction. After solution and aging treatment, the impact toughness improves significantly. With the solution temperature increasing, impact toughness first increases and then decreases.
BREATHS: A Novel Endotracheal Tube Design to Decrease the Incidence of Tracheal Lesions
Authors: Crowley Madeline Monahan , Lingawi Saud , Tariq Omar , Goubran Daniel , Johal Sunny , Smith Andrew , Tam Roger
Published: March 2022

Background
Prolonged intubation is associated with the development of tracheal stenosis due to cuff pressures causing endothelial ischemia, potentially leading to tracheal stenosis at the cuff site. This may result in airway obstructions requiring surgical intervention. Objective to develop a modification to endotracheal tube cuffs to put less pressure against the tracheal walls to decrease the risk of developing post-ventilation tracheal stenosis.
Methods
A modified endotracheal tube cuff was designed using a double balloon cuff design, with an outer fixed cuff and an inner cuff that expands and deflates with the respiratory cycle. The design allows for the cuff pressure applied to the trachea to be maximal during inspiration and minimal during expiration, coinciding with pressures required to maintain an air seal.
Results
During inspiration, the pressure on the tracheal wall is equal to that of a standard endotracheal tube. During expiration, the pressure applied on the tracheal walls is less than that of a standard endotracheal tube. The minimal pressure throughout the cycle decreased to baseline throughout the respiratory cycle due to minimal cuff inflation by the end of expiration, as most air is removed.
Conclusions
The modified cuff demonstrates an overall decreased pressure applied to the trachea, with potential to enable microvascular perfusion, improve blood flow, and decrease risk of tracheal lesions and stenosis. Further testing with more ventilatory conditions, endotracheal tube, tracheal, and lung analog sizes, and in-vivo testing efforts are required to ascertain if this innovation’s clinical benefit.
Iron-Catalyzed Ligand-Controlled Silylation or Borylation of Ni-triles with Bpin-SiEt3 via C-CN Bond Cleavage
Authors: Cao Ying , Zhang Huan , Zeng Xiaoqin , Liu Zhengli , He yun , Feng Zhang
Published: March 2022

The first example of iron-catalyzed ligand-controlled silylation or borylation of the same nitriles via C-CN bond cleavage using a common silylborane reagent as either the silyl or boryl source has been developed. The same nitriles can undergo silylation well with a bulky oxalic diamide ligand or borylation smoothly in the presence of P(t-Bu)3HBF4, delivering the corresponding silylated or borylated products with excellent chemoselectivities. This protocol exhibits good functional group tolerance and enables the late-stage silylation or borylation of bioactive compounds, thus offering excellent opportunities for applications in drug discovery and development.
Engineering an Oilseed Crop for Hyper-Accumulation of Carotenoids in the Seeds without Using a Traditional Marker Gene
Authors: He Ming-Xia , Wang Jie-Lin , Lin Yuan-Yuan , Liu Aizhong , Huang Jun-Chao , Chen Feng
Published: March 2022

Camelina sativa (L.) Crantz is an important oil crop with many excellent agronomic traits. This model oil plant has been exploited to accumulate value-added bioproducts using genetic manipulation that depends on antibiotic- or herbicide-based selection marker genes (SMG), one of the major concerns for genetically modified foods. Here we reported metabolic engineering of C. sativa to synthesize red ketocarotenoids that could serve as a reporter to visualize transgenic events without using a traditional SMG. Overexpression of a non-native β-carotene ketolase gene coupled with three other carotenogenous genes (phytoene synthase, β-carotene hydroxylase, and Orange) in C. sativa resulted in production of red seeds that were visibly distinguishable from the normal yellow ones. Constitutive expression of the transgenes led to delayed plant development and seed germination. In contrast, seed-specific transformants demonstrated normal growth and seed germination despite the accumulation of up to 70-fold the level of carotenoids in the seeds compared to the controls, including significant amounts of astaxanthin and keto-lutein. As a result, the transgenic seed oils exhibited much higher antioxidant activity. No significant changes were found in the profiles of fatty acids between transgenic and control seeds. This study provided a novel tool for metabolic engineering of seed crops without using a disputed SMG.
Child Growth Monitoring and Promotion Practice and Associated Factors among Health Care Workers at Public Health Institutions in South Wollo Zone, Northeast Ethiopia: An Institution based Cross Sectional Study
Authors: Kebede Getabalew Getachew , Ahmed Kemal , Ali Yeshimebet
Published: March 2022

Background
Even though Growth Monitoring and Promotion (GMP) has been practicing in many countries including Ethiopia for well children less than two years of age to prevent malnutrition, there is still a chance to acquire malnutrition in Ethiopia. However, there is no study that documented the proportion of GMP practice and associated factors in the study area. Therefore, the aim of this study was to assess GMP practice and identify associated factors among health care workers.
Methods
Institution based cross- sectional study design was employed on 397 randomly selected health care workers in South Wollo Zone, northeast Ethiopia from May 25 to July 7, 2020. Pre-tested self-administered questionnaire and in-depth interview were used to collect data. Quantitative data were analyzed using SPSS version 20.0 software. Thematic analysis was applied to the qualitative part. Bivariable and multivariable logistic regressions were used to identify associated factors with GMP practice. Statistical tests at P-value < 0.05 with 95% confidence interval were taken for statistical significance.
Results
The proportion of GMP practice among health care workers was 58.4% with (95% CI: 54.0–63.0). First degree (AOR = 2.25; 95% CI: 1.005, 5.05), diploma (AOR = 3.52; 95% CI: 2.04, 6.09), work experience on GMP (AOR = 3.13; 95% CI: 1.58, 6.20), GMP training (AOR = 4.83; 95% CI: 2.89, 8.06), GMP equipment (AOR = 2.75; 95% CI: 1.64, 4.58) and attitude towards GMP (AOR = 3.70; 95% CI: 2.228, 6.174) were factors significantly associated with GMP practice.
Conclusions
The proportion of GMP practice among health care workers was 58.4%. Educational level, work experience on GMP, GMP training, GMP equipment and attitude towards GMP were positively associated with GMP practice. Therefore, Ministry of Health should strengthen availability of GMP equipment, GMP training, and bring positive attitude towards GMP to improve GMP practice with special focus on health care workers with lower experience on GMP service.
Fabricated Hybrid Composites with Insect-Repellent Property
Authors: Babayo Hajara , Musa Haruna , Garba Mustapha D.
Published: March 2022

An insect repellent composite containing tiger nut particulate fibre, waste low density polyethene (LDPE) and castor oil alkyd resin (COAR) was fabricated. Canarium schweinfurthii gum used as insect repellent compound and maleic anhydride as compatibilizer. The tiger nut chaff was subjected to benzoylation using benzoyl chloride to increase fibre-matrix interaction. The compound and composition thereof moulded with LDPE as dual matrices for excellent physico-mechanical properties (pressed for 5 min, 130 °C and 25 bar and cured). Least water absorption of ~0.085 %, optimal chemical resistance for both acids (HCl and H2SO4) and bases (NaOH and KOH) and no effect on thickness was observed with the 10 wt.% treated composite. Density measurement showed the lowest value of ~0.0096 g/cm3 for the treated fibre composite. However, the tensile strength, flexural stress, hardness and impact load were improved up to 35.08 Mpa, 456.3 Mpa, 95 and 730 J/m respectively with treated composites. Insect repellent test against termites and cockroaches shows repellent activity with time intervals. FTIR and SEM analysis showed fibre modification achieved.
A redundant sensing device schedule method under event monitoring coverage constraints for edge computing
Authors: Chen Xiangwei , Long Jun , Zhang Jinhuan
Published: March 2022

Billions of sensing devices are deployed in the smart city to generate a large amount of sensing data for various applications. However, duplicated data caused by redundant deployed sensing devices makes it a great challenge to gather data with low cost and high efficiency. In this paper, a redundant sensing device schedule method is proposed through redundant sensing device identification scheme based on device redundancy and similarity (RSDI-DRS) under event monitoring coverage constraints. The key idea of the RSDI-DRS is to reduce the number of unnecessary working sensing device to decrease energy consumption and data load. Comparing to the previous researches, the innovation of RSDI-DRS is as follows: First, a novel sensing device redundancy and similarity calculation method is proposed. Second, the network connectivity is realized by the network connectivity discrimination scheme. In the proposed scheme, the redundant device set is established by calculating the sensing device redundancy score. Then, the device similarity score is calculated for the devices in the redundant device set, and the scheduling priority of the redundant device is obtained based on the similarity score and the remaining energy of the sensing device. The device with the maximum scheduling priority is scheduled to sleep. The process loops under the satisfaction of event coverage constraint. Meanwhile, the network connectivity is realized in the process. If an isolated sensing device occurs, the neighbor device with the minimum scheduling priority will not be scheduled to sleep. Simulation results show that the proposed scheme could prolong the network life by 16.30% ~ 31.18% and realized the connectivity of working sensing devices under the event monitoring coverage at the cost of the execution time growth compared with the scheme of Relocating Redundant Sensors-Redundant Node Identification (RRS-RNI).
Mitochondrial Phosphate Carbokinase Inhibits Renal Cell Carcinoma Malignant Progression, Leading to Cell Energy Metabolism Imbalance
Authors: Chen Yeda , Yang Shuxin , Huang Yapeng , Wang Zhu , Deng Qiong , Chen Yuting , Yu Qingfeng , Liang Hui
Published: March 2022

Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) is a key gluconeogenesis enzyme. Its differential expression is related to renal cell carcinoma (RCC) malignancy, possibly by influencing energy metabolism.We found that, compared with 293t, PCK2 was downregulated in six RCC lines. Relative to surrounding tissues, PCK2 was downregulated in RCC. PCK2 overexpression inhibited RCC proliferation. PCK2 overexpression inhibited RCC migration and invasion. Mass spectrometry revealed that thiamine pyrophosphate, cyclic AMP, beta-D-Fructose 6-phosphate, lactate, flavin mononucleotide, NAD, NADP, D-Glucose 6-phosphate were upregulated. In conclusion, our results showed that PCK2 overexpression inhibited RCC proliferation, migration, and invasion and upregulated energy metabolite expression.
Comprehensive diagnostic criteria for MELAS syndrome: A case study involving an elderly patient with MT-TWm.5541C>T mutation
Authors: Wu Gang , Shen Yuguang , Zhu Feng , Tao Weiwei , Zhou Yuanlin , Ke Shaofa , Jiang Huihua
Published: March 2022

Background
Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a matrilineal hereditary multi-system disease due to mutations of mitochondrial DNA. Though the initial diagnostic criteria prevail till nowadays, which take a range of clinical phenotypes into consideration including clinical onset after the age of 40, a confirmative diagnostic standard for MELAS is still needed.
Case presentation:
A 71-year-old female patient presented with recurrent stroke to our hospital. Magnetic resonance imaging showed a cerebral gyrus-like area with hyperintensity in the parietal-occipital lobe on DWI and this area expanded with disease progression. The Lac/Lip peaks were significantly inverted in the MRS imaging. Nucleic acid sequencing showed a MT-TWm.5541C>T mutation, and the mutation rate of the blood sample was 12.86%. The patient had a 6-year history of type 2 diabetes. The patient experienced recurrent stroke and was given coenzyme Q10 capsules and idebenone tablets to improve metabolism, vitamin B to nourish nerves, edaravone to scavenge oxygen free radicals, and oxcarbazepine to manage seizures. At 1-month follow-up, her condition was stable.
Conclusion
Patients with MELAS syndrome have complex clinical manifestations. Our data demonstrated that, for patients with atypical cerebral infarction and suspected MELAS syndrome, gene sequencing and muscle biopsy should be completed in time, which may serve as a reference for the diagnostic criteria of MELAS syndrome.
Placental Cryptococcosis in an HIV Infected Woman with Eclampsia: A Rare Case Report
Authors: A Shruthi , Jadhav Meena N , Kittur S K , Lakshmi K S
Published: March 2022

Cryptococcosis is not uncommon, especially among immunocompromised patients. However, placental cryptococcosis is rare, with few reported cases in the literature. A 21 yr. old primigravida, a known case of HIV was admitted to hospital at 36 weeks gestation for antepartum hemorrhage. Her vital signs were within normal limits. Her laboratory investigations revealed hemoglobin-6 gm%. The peripheral smear showed microcytic hypochromic anemia. Urine showed traces of albumin. On the sixth day of admission, she developed features of eclampsia and delivered a male baby of birth weight 1700 gm. The placenta weighed 350 gm. Microscopy of placenta showed marked perivillous fibrin deposits, decidual arteriopathy and syncytial knots. At places, cryptococci were seen which showed thick capsule around them. A diagnosis of placental cryptococcosis with features of eclampsia was made. On the third day postpartum, she developed drowsiness and disorientation. CSF analysis was suggestive of cryptococcal meningitis. On the fifth day postpartum, patient died of DIC and multiorgan failure. It is important to establish the involvement of placenta by the opportunistic infections like Cryptococcus neoformans in immunocompromised women, so that the baby and the mother can be instituted with immediate appropriate management.
EDUCAÇÃO SEXUAL PARA A DIVERSIDADE: QUESTÕES DE GÊNERO E EDUCAÇÃO
Authors: De Vargas Rosana Souza , Beerbaum Alisson Vercelino , De Oliveira Boff Eva Teresinha
Published: March 2022

Existem profundas transformações na fase da adolescência: biológicas, sociais, emocionais e de saúde. A partir do entendimento de que é no ambiente escolar que os adolescentes passam a maior parte do tempo, compreendemos ser importante tratar a temática com foco na Educação Sexual. Aqui, referimo-nos a uma educação que seja ética, humana e que proporcione conhecimentos sobre aspectos físicos, cognitivos, sociais, culturais e emocionais para jovens e adultos. No entanto, estudos demonstram que a temática é pouco trabalhada no ambiente escolar, classificada como um tabu. Assim, o presente artigo tem o objetivo de apresentar aspectos relacionados às temáticas de Educação Sexual e Gênero apresentados nos discursos de estudantes do Ensino Médio de uma Escola Pública localizada numa cidade do interior do Rio Grande do Sul, BR. O estudo caracteriza-se como qualitativo e a análise das falas ocorreu por meio da Análise Textual Discursiva. Os resultados apontam que, por mais que os alunos apresentem certas noções acerca do que seja educação sexual e gênero, como de reprodução e prevenção de doenças, tais informações ainda não tratam de conceitos abstraídos nos sentidos próprios dos termos. Acreditamos que é a partir da educação sexual e de sua discussão efetiva e responsável nas escolas que pode haver uma transformação social e cultural de práticas sexuais, promovendo a não alienação dos jovens e adolescentes em relação à temática.
MEMÓRIAS DO BRASIL: INVASÃO, TRÁFICO DE NEGROS E VIOLÊNCIA
Authors: Machado Pedro Henrique , Santos Samara Silva dos
Published: March 2022

O presente artigo apresenta um panorama histórico do violento processo que os povos originários do Brasil e os povos africanos sofreram no Brasil na época da colonização. Portanto, o artigo faz um passeio pela história do Brasil, a partir dos anos de 1500, passando pela escravização dos povos indígenas e transitando pela escravização dos povos africanos submetidos à escravidão pelas elites coloniais da época. Para a realização deste trabalho escolhemos como recurso metodológico a revisão de literatura. Diante do que foi apresentado no decorrer deste trabalho podemos considerar que desde os primórdios da colonização do Brasil as populações minoritárias como os indígenas e os africanos escravizados foram submetidos a diferentes tipos de violência, as quais repercutem até os dias atuais.
Autoaprendizaje mediado por las TIC. Estudio de caso: alumnado de la maestría en educación
Authors: Urcid Puga Rodrigo
Published: March 2022

El siguiente texto tiene por objetivo mostrar cuáles fueron las herramientas tecnológicas que más impactaron en el alumnado del Tecnológico de Monterrey que cursa la maestría en educación -modalidad online-. En este sentido, se busca conocer cómo a través de los diferentes cursos transitados a lo largo de dicho posgrado, el estudiantado pudo ser capaz de gestionar su aprendizaje y utilizar las distintas TIC a su favor. La metodología aplicada es de corte cualitativo, y se sustenta en la herramienta de entrevistas profundas/intensas; en particular se aplica esta técnica al alumnado que cursa cualquiera de las tres fases de la materia: Proyecto de Investigación Aplicada (PIA), es decir, alumnos y alumnas que ya culminaron la mayoría de sus materias y actualmente desarrollan su tesis. Como resultado, se encuentra que con el uso de distintas herramientas tecnológicas como aplicaciones, presentaciones, aplicaciones que fomentan el trabajo colaborativo, grabaciones asincrónicas, videos, etc., En conclusión, tanto la constante comunicación, como el nuevo rol del profesorado, y distintos recursos tecnológicos enfocados en la enseñanza, son determinantes para que el estudiantado sea capaz de gestionar su tiempo para mejorar su propio proceso de aprendizaje y administrar sus actividades para llevarlas a cabo en tiempo y forma.
Instrumento de evaluación para el desarrollo de cursos en entornos virtuales de enseñanza-aprendizaje
Authors: Trejo González Hugo
Published: March 2022

El objetivo de esta investigación fue construir un instrumento de referencia para el seguimiento y evaluación en la construcción de cursos en entornos virtuales de enseñanza-aprendizaje. Para esto, se hizo una revisión exhaustiva de diferentes teorías y enfoques de diseño instruccional, enseñanza-aprendizaje y perspectivas sobre la comunicación e interacción en entornos virtuales. A través de un estudio de tipo fundamental y cualitativo se analizaron enfoques y perspectivas para el diseño de entornos educativos virtuales dando como resultado la redacción de pautas con base en cinco categorías: diseño instruccional, enfoque pedagógico, arquitectura de la instrucción, diseño web y netiquetas. Aunque este trabajo se enmarca en la enseñanza a distancia, el instrumento creado podría servir como base para el diseño de cursos en entornos presenciales. Como resultado, se diseñó un instrumento de seguimiento y evaluación que pretende impactar directamente en la concepción pedagógica y didáctica de cursos a fin de coadyuvar a la comprensión de la complejidad en la construcción de entornos virtuales de aprendizaje.
Metformin has no Significant Anticancer Effect on Patients with Advanced or
Unresectable Cancer: A Systematic Review and Meta-analysis
Authors: Gan Xinyan , Cao Chang , He Yan , Hu Xiaolin , Peng Xingchen , Su Yonglin
Published: March 2022

Background:

At present, the antitumor effect of metformin is controversial. Previous meta-analyses
included observational studies, of which the results can be influenced by many confounders, affecting the result of
meta-analyses and weakening the strength of evidence. Therefore, we conducted a meta-analysis to confirm the effect
of metformin use on patients with advanced or unresectable cancers, including randomized clinical trials (RCTs).

Methods:

We searched for RCTs in accordance with the inclusion and exclusion criteria. A meta-analysis was
conducted to combine hazard ratios (HRs) or risk ratios (RRs) and their 95% confidence intervals (CIs) using a
random-effects model.

Results:

Finally, 7 eligible RCTs were included in the meta-analysis. Overall, the combined results revealed that
treatment with metformin did not improve the overall survival (OS) of patients (HR, 1.12; 95% CI, 0.91-1.37,
p>0.05), and there was no clear evidence that metformin use was related to improved progression-free survival (PFS)
(HR, 1.17; 95% CI, 0.97-1.40; p>0.05). The pooled RR for grade III or IV adverse events was 0.92 (95% CI, 0.52-
1.60; p>0.05), indicating that the use of metformin was not significantly related to increased toxicity.

Conclusion:

Metformin does not significantly improve the survival of patients with advanced or unresectable
cancer, regardless of cancer type and region.
Open Science Framework: DOI 10.17605/OSF.IO/SPKE8.
Treatment of Adult Spinal Muscular Atrophy: Overview and Recent Developments
Authors: Brakemeier Svenja , Stolte Benjamin , Kleinschnitz Christoph , Hagenacker Tim
Published: March 2022

Spinal muscular atrophy (SMA) is a rare genetic neuromuscular disease leading to progressive and,
in many cases, severe muscle weakness and atrophy in the natural disease course. An increasing number of
gene-based treatment options have become available in recent years. Growing knowledge regarding the underlying
genetic mechanisms makes the disease well amenable to them. Over the past few years, data on new
treatments, their mechanisms of action and therapeutic outcomes have been published, reflecting the current
dynamics in this field. With the approval of the antisense oligonucleotide nusinersen, the vector-based therapy
with onasemnogene abeparvovec and the small molecule splicing modifier risdiplam, three gene therapeutic
drugs are available for the treatment of SMA showing improvement in motor function. But in the pivotal studies,
several relevant parameters have not been addressed. There is a data gap for the treatment outcome of adult
individuals with SMA as well as for several other relevant outcome parameters, like bulbary or ventilatory
function. With increasing treatment options, additional individual therapies have become necessary. Studies on
combination therapies or switch of therapy, e.g., the sequential administration of onasemnogen abeparvovec
and nusinersen, are necessary. An overview of current developments in the field of therapeutic options for adult
SMA is presented. Important characteristics of each therapeutic options are discussed so that the reader can
comprehend underlying pathophysiological mechanisms as well as advantages and disadvantages of each therapy.
The focus is on gene-based treatment options, but options beyond this are also addressed.
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents:
Current Developments and Mechanisms of Action
Authors: Zou Yulin
Published: March 2022

Cancer is claimed as a prevalent cause of mortality throughout the world. Conventional chemotherapy plays a pivotal role in the treatment of cancers, but multidrug resistance has already become one of the major impediments to efficacious cancer therapy, creating a great demand for the development of novel anticancer drugs. Steroidal saponins, abundantly found in nature, possess ex-tensive structural variability, and some naturally occurring steroidal saponins exhibit profound anti-cancer properties through a variety of pathways. Hence, naturally occurring steroidal saponins are powerful lead compounds/candidates in the development of novel therapeutic agents. This review article described the recent progress of naturally occurring steroidal saponins as potential anticancer agents, and the mechanisms of action were also discussed, covering articles published between 2017 and 2021.
Trait Anger, Hostility, and the Risk of Type 2 Diabetes and Diabetes-
Related Complications: A Systematic Review of Longitudinal Studies
Authors: Deschênes Sonya S. , Mohseni Marzia , Lindekilde Nanna , Forget Geneviève , Burns Rachel J. , Pouwer Frans , Schmitz Norbert
Published: March 2022

Background:

Research suggests associations between trait anger, hostility, and type 2
diabetes and diabetes-related complications, though evidence from longitudinal studies has not yet
been synthesized.

Objective:

The present systematic review examined findings from longitudinal research on trait
anger or hostility and the risk of incident type 2 diabetes or diabetes-related complications. The review
protocol was pre-registered in PROSPERO (CRD42020216356).

Methods:

Electronic databases (MEDLINE, PsychINFO, Web of Science, and CINAHL) were
searched for articles and abstracts published up to December 15, 2020. Peer-reviewed longitudinal
studies with adult samples, with effect estimates reported for trait anger/hostility and incident diabetes
or diabetes-related complications, were included. Title and abstract screening, full-text
screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale were conducted
by two independent reviewers. A narrative synthesis of the extracted data was conducted
according to the Synthesis Without Meta-Analysis guidelines.

Results:

Five studies (N = 155,146 participants) met the inclusion criteria. While results were
mixed, our synthesis suggested an overall positive association between high trait-anger/hostility
and an increased risk of incident diabetes. Only one study met the criteria for the diabetes-related
complications outcome, which demonstrated a positive association between hostility and incident
coronary heart disease but no significant association between hostility and incident stroke.

Conclusion:

Based on the available longitudinal evidence, trait anger and hostility are associated
with an increased risk of diabetes. Longitudinal studies are needed to investigate the association
between trait-anger or hostility and the risk of diabetes-related complications.
Utilization of E-Learning Media the Independence Learning of Elementary School Students
Authors: - Iswan , - Ismah , Astriani Linda , - Mimah
Published: March 2022

Research with the title Utilization of e-learning media the independence learning of elementary school students. This study aims to determine the relationship between the effectiveness of e-learning learning on the learning independence of elementary school students. This research was conducted in Grade V of elementary school, which consist of school, namely: MI Ahmad Dahlan Cipanas, SD Aisyiyah Islamic Center Cianjur, and SD Islamic Creative Cianjur Indonesia. The research method used in this study is a quantitative descriptive approach with a correlation method. The results showed that the variable utilization of e-learning learning media had a significant effect on the learning independence of elementary school students. Based on the statistical test results, the partial t test shows that the significance value of the effect of learning effectiveness (X1) on independence (Y) is 0.003<0.5 and the value of tcount>ttable=3,089>1,980 then Ho1 is rejected and Ha1 is accepted which is means that there is an influence on the use of e-learning learning media (X1) on students learning independence (Y). And the results of the t-test (partial) show that the significance value has the effect of e-learning (X2) on student learning independence (Y) is 0.000<0.05 and the value of tcount>ttable =7,687>1,980 then Ho2 is rejected and Ha2 is accepted which can be concluded that there is an influence on the use of e-learning learning media (X2) on the learning independence of elementary school students (Y). According to the results of the regression significance test (F-test) which shows that the value of sig. f-test of 0.000<0.05, so that all independent variable consisting of the use of e-learning learning media have a simultaneous effect on the learning independence of elementary school students at MI Ahmad Dahlan students of SD Aisyiyah Islamic Center, and students of SD Islamic Creative Cianjur Indonesia.
The Influence of Employees’ Power Distance Orientation on Their Well-being—Moderating Effects Based on Generational Differences
Authors: Xinyi Ye , Xinpeng Xu
Published: March 2022

From the perspective of organizational behavior, the work reward obtained by workers is not limited to labor reward, but also should include psychological reward such as happiness at work. Through questionnaire survey, relevant data were obtained to explore the influence of power distance orientation on employees’ happiness at the individual level. The results show that there are significant intergenerational differences in employees’ power distance orientation, employees’ subjective happiness has a moderate positive impact on power distance orientation, and intergenerational differences have a negative moderating effect on the relationship between employees’ power distance orientation and employees’ happiness to some extent.
Design of Manual Operated Oil Extraction Machine
Authors: Vaidya Vivek , Girhe Ashwin , Lanjewar Chetan , Thakre Sarang , Chavhan Shailendra , Vaidya Pushpak , Humane Snehal
Published: March 2022

Abstract: This paper aim on design and Development of pedal operated Seed oil extraction machine. The machine is portable which makes it light in weight and can be used for small scale industries and for Household and Pure oil extraction. Since this machine requires less space to move, it can be used in a more versatile manner as compared to heavy powered machines that are mounted on heavy and large industries. This machine can be efficient and easy to operate and maintain. The oil extracted has various applications in food, medicine, and industry (1). This paper is also aim on Literature Sur-vey on various mechanism used by top Universities professors According to the Need. Keywords: Expeller, Design, Chain, Speed, Seeds, Oil.
Legal Regime for the Enforcement of Foreign Court Judgments and Arbitral Awards in the Eurasian Economic Union
Authors: Kurochkina E. M.
Published: March 2022

In today’s world, there is intense competition between integration entities that are working to strengthen and expand their political and economic positions. This article examines the movement of the Eurasian Economic Union in this direction. Aim. To propose a way to ensure a common legal space in the Eurasian Economic Union.

Tasks. To analyse the regulation in force in the Eurasian Economic Union on the execution of court judgments and arbitral awards, to identify problems that member states of the Eurasian Economic Union may encounter in the execution of court judgments and arbitral awards.

Methods. In this work were used both general scientific methods of knowledge: analysis, synthesis, generalization, and particular scientific methods: formal-logical, formal-legal, comparative-legal, method of legal prediction.

Results. One of the most acute problems faced by states in the execution of judicial and arbitral decisions is the problem of execution of annulled judicial or arbitral decisions. To prevent this problem within the European Economic Union, the author considers that the members of the European Economic Union should not accede to the Convention on the Recognition and Enforcement of Foreign Judgements in Civil or Commercial Matters of 2 July 2019, as it does not resolve the fate of annulled judgements. With regard to arbitral awards, it would be desirable for the Member States of the European Economic Union to conclude between themselves a protocol to the Convention on the Recognition and Enforcement of Arbitral Awards of 10 June 1958, which would exclude the enforceability of annulled arbitral awards in all the States parties to the Protocol. The drafting of this additional protocol could be entrusted to the Eurasian Economic Commission of the European Economic Union.

Conclusions. The Eurasian Economic Union needs to create a predictable legal space, which would primarily be ensured by the free movement of judicial and arbitral decisions.
Pengetahuan dan Persepsi Masyarakat Terhadap Konflik Gajah Sumatera di Desa Lubuk Mandarsah
Authors: Ginda Ginda Bahari , Syarifuddin Hutwan , Hamzah Hamzah
Published: March 2022

The condition of the Bukit Tigapuluh National Park, which is directly adjacent to agricultural land and residential areas of the Lubuk Mandarsah Village community as well as the existence of a concession permit causes a high potential for conflict between Sumatran elephants and the community. The decline in biodiversity due to overexploitation of natural resources, the conversion of company land around the Bukit Tigapuluh National Park has a negative impact on the conservation of Sumatran elephants and the survival of the people living around the buffer area of ​​the Bukit Tigapuluh National Park. With this problem, it will certainly cause conflict between humans and Sumatran elephants. The purpose of this study was to determine the knowledge and perceptions of the community towards conflicts with Sumatran elephants. This research is research using mixed method or mix method, which combines qualitative and quantitative methods. Based on this research, it was found that the level of community knowledge in the hamlet of Lubuk Mandarsah Village regarding Sumatran Elephants was classified as high (39-48) with a percentage of 82% and the perception of people in Lubuk Mandarsah Village regarding Sumatran elephants was classified as bad with a percentage of 78%.
Key words: knowledge, perception, public, Sumatran Elephant
 
Abstrak. Kondisi Taman Nasionnal Bukit Tigapuluh yang berbatasan langsung dengan lahan pertanian dan pemukiman masyarakat Desa Lubuk Mandarsah  serta adanya perizinan konsesi menyebabkan tingginya potensi konflik gajah sumatera dengan masyarakat. Penurunan keanekaragaman hayati akibat eksploitasi sumber daya alam yang berlebihan, konversi lahan perusahaan sekitar Taman Nasional Bukit Tigapuluh menimbulkan dampak negatif terhadap konservasi gajah sumatera dan keberlangsungan hidup masyarakat yang hidup disekitar daerah penyangga Taman Nasional Bukit Tigapuluh. Dengan adanya permaslaahan ini tentu akan menimbulkan konflik antara manusia dan gajah sumatera. Adapun tujuan dari penelitian ini adalah mengetahui pengetahuan dan persepsi dari masyarakat terhadap konflik dengan gajah sumatera. Penelitian ini merupakan penelitian menggunakan metode campuran atan mix method dimana mengkombinasikan metode Kualitatif dan kuantitatif. Berdasarkan penelitian ini dihasilkan bahwa Tingkat Pengetahuan Masyarakat di dusun Desa Lubuk Mandarsah terkait Gajah Sumatera sudah tergolong Tinggi (39-48) dengan persentase sebesar 82 % dan persepsi masyarakat di Desa Lubuk Mandarsah terkait gajah sumatera masik tergolong tidak baik dengan persentase 78%. 
Kata kunci: Pengetahuan, Persepsi, Masyarakat, Gajah Sumatera
Studi Literature Review: Faktor-Faktor yang Mempengaruhi Food Choice Pada Remaja Pasca Pandemik COVID-19
Authors: Pua Amaizing Evangelin , Renyoet Brigitte Sarah
Published: March 2022

Dunia dilanda wabah virus yang disebut dengan COVID-19 hingga saat ini masih menjadi fokus utama masalah kesehatan yang perlu diselesaikan dari setiap negara di belahan dunia. Masalah kesehatan yang terjadi mempengaruhi Food choice pada setiap kalangan usia tak terkecuali pada remaja. Tujuan penulisan artikel ilmiah ini ialah untuk mengkaji faktor terkait yang mempengaruhi food choice pada remaja pasca pandemik COVID-19. Metode yang digunakan pada penulisan penelitian ini adalah study literature review, yang menganalisis dan mengumpulkan artikel-artikel penelitian mengenai faktor food choice pada remaja pasca pandemik COVID-19. Kebanyakan remaja telah mampu memilih makanan apa yang ingin di konsumsi, berbeda dengan masa kanak-kanak yang perlu dibimbing orang tuanya dalam mengkonsumsi makanan. Terdapat perubahan keputusan remaja dalam mengkonsumsi makanan yang sehat dan tidak sehat di masa pandemik COVID-19, hal ini di pengaruhi oleh beberapa faktor diantaranya ialah media periklanan di media sosial, harga produk pangan, jangkauan terhadap pangan yang terbatas, rasa bosan dan kesadaran remaja terhadap gaya hidup sehat. Dimasa pandemik ini terjadi perubahan pemilihan makanan terhadap remaja, terlihat dari banyaknya faktor yang mempengaruhi food choice pada remaja pasca pandemik COVID-19 yaitu faktor pengetahuan dan kesadaran remaja, ketersediaan pangan di masa lock-down, media sosial dan faktor emosional pada remaja.