bluuebunny/crossref_metadata_2025 huggingface dataset:
New Discovery of Left Atrial Macroreentry Tachycardia: Originating from the Spontaneous Scarring of Left Atrial Anterior Wall
Authors: Zhu Xuefeng , Chu Hongxia , Li Jianping , Wang Chunxiao , Li Wenjing , Wang Zhen , Xu Zhiyuan , Jing Yanyan , Zhao Ruifu , Zhong Lin , Hu Naibao
Published: December 2021

Aims. This study sought to describe left atrial macroreentry tachycardia (LAMRT) originating from the spontaneous scarring of left atrial anterior wall (LAAW) and its clinical and electrophysiological characteristics, mechanisms, and the formation of substrates. Methods and Results. 9 of 123 patients (89% female, age 79.78 ± 5.59 years) had LAMRT originating from the LAAW with no cardiac surgery or prior left atrial (LA) ablation. The mean tachycardia cycle length (TCL) was 241.67 ± 38.00 milliseconds. Spontaneous scars areas and low voltage areas (LVAs) in the LAAW were found in all patients. Successful ablation of the critical isthmus caused termination of the LAMRT and was not inducible in all patients. Arrhythmogenic substrates of LAMRT were the spontaneous scars of LAAW, which matched with the aorta or/and pulmonary artery contact area. The area under the curve (AUC) of age and combination of gender and age for predicting the LAMRT originating from the LAAW were 0.918 and 0.951, respectively, with a cutoff value of ≥73.5 years of age and gender (female) predicting LAMRT with 88.9% sensitivity and 89% specificity. Conclusion. Combination of gender and age provides a simple and useful criterion to distinguish LAMRT from cavotricuspid isthmus- (CTI-) dependent atrial tachycardia in macroreentry atrial tachycardia (MRAT) in patients without a history of surgery or ablation. Aorta or/and pulmonary artery contacting LA may be related to spontaneous scars. Ablation the isthmus eliminated LAMRT in all patients.
The Family of Multiparameter Quaternary Subdivision Schemes
Authors: Mustafa Ghulam , Asghar Muhammad , Ali Shafqat , Qamar Arzoo , Liu Jia-Bao
Published: December 2021

In the field of subdivision, the smoothness increases as the arity of schemes increases. The family of high arity schemes gives high smoothness comparative to low arity schemes. In this paper, we propose a simple and generalized formula for a family of multiparameter quaternary subdivision schemes. The conditions for convergence of subdivision schemes are also presented. Moreover, we derive subdivision schemes after substituting the different values of parameters. We also analyzed the important properties of the proposed family of subdivision schemes. After comparison with existing schemes, we analyze that the proposed family of subdivision schemes gives better smoothness and approximation compared with the existing subdivision schemes.
Effects of Traditional Chinese Medicine for Vaginal Lavage Combined with Psychological Intervention in Postoperative Patients with Cervical Cancer
Authors: Ma Rufen , Yu Ruixiang , Yuan Yuchao , Ren Baofeng , Li Yuan
Published: December 2021

Purpose. To explore the effects of traditional Chinese medicine for vaginal lavage combined with psychological intervention on the immune function and clinical efficacy in patients with cervical cancer. Methods. Patients with cervical cancer treated in our hospital from January 2020 to May 2021 were included in this study. All patients were treated with traditional Chinese medicine for vaginal lavage combined with psychological nursing intervention. The treatment outcomes of the patients were observed, and the quality-of-life scores and depression of the patients before and after treatment were compared. Changes in T-lymphocyte subset-related indicators, changes in blood routine-related indicators, and changes in the detection level of tumor markers were compared with anxiety scores. Results. After treatment, depression and anxiety were significantly reduced and the patient’s quality of life significantly improved. After treatment, the patient’s CD3+, CD4+, and CD4+/CD8+ proportions were dramatically higher than before treatment (

P
<
0.05

), there was no significant difference in CD8+ proportion before and after treatment (

P
>
0.05

), and the white blood cell (WBC), hemoglobin (Hb), platelet (PLT) of patients, and the level of tumor marker (CA125) after treatment were immensely lower than before treatment (

P
<
0.05

). Conclusions. Treating patients with cervical cancer with traditional Chinese medicine for vaginal lavage combined with psychological nursing can effectively improve the patient’s immune function, effectively reduce the level of tumor marker CA125, increase the level of T-lymphocyte subsets, and improve the bone marrow hematopoietic function.
An English Online Homework Tutoring System Supported by Internet Database
Authors: Hao Huanxiang
Published: December 2021

College English tutoring is an important content of current research, and how to provide more effective methods for teaching tutoring is currently a hot research topic. Therefore, this paper designs an Internet-based online tutoring platform for college English teaching, which is accelerated by using the K-means clustering algorithm. The data processing efficiency and processing methods to improve user satisfaction require more practical experience to summarize. In the business logic layer, the uploaded information is mined through the K-means clustering algorithm to form an online tutoring university English database to provide platform data support, realize the business logic judgment of the data, convert the data in the database, and return to the user interface of other formats, to provide users with browsing and consulting. In the data access layer, the data from the business logic layer is processed. After the processing is completed, data can be added, deleted, modified, and checked in the database. Finally, the operation result of the database is fed back to the business logic layer for processing. Experimental results show that the designed platform has good data mining performance, low connection speed and low response delay, good compatibility, low CPU usage, fast resource sharing speed, and high user satisfaction. It can be connected to different operating systems.
Exploring the Pivotal Neurophysiologic and Therapeutic Potentials of Vitamin C in Glioma
Authors: Richard Seidu A. , Sackey Marian , Kortei Nii Korley
Published: December 2021

Gliomas represent solely primary brain cancers of glial cell or neuroepithelial origin. Gliomas are still the most lethal human cancers despite modern innovations in both diagnostic techniques as well as therapeutic regimes. Gliomas have the lowest overall survival rate compared to other cancers 5 years after definitive diagnosis. The dietary intake of vitamin C has protective effect on glioma risk. Vitamin C is an essential compound that plays a vital role in the regulation of lysyl and prolyl hydroxylase activity. Neurons store high levels of vitamin C via sodium dependent-vitamin C transporters (SVCTs) to protect them from oxidative ischemia-reperfusion injury. Vitamin C is a water-soluble enzyme, typically seen as a powerful antioxidant in plants as well as animals. The key function of vitamin C is the inhibition of redox imbalance from reactive oxygen species produced via the stimulation of glutamate receptors. Gliomas absorb vitamin C primarily via its oxidized dehydroascorbate form by means of GLUT 1, 3, and 4 and its reduced form, ascorbate, by SVCT2. Vitamin C is able to preserve prosthetic metal ions like Fe2+ and Cu+ in their reduced forms in several enzymatic reactions as well as scavenge free radicals in order to safeguard tissues from oxidative damage. Therapeutic concentrations of vitamin C are able to trigger H2O2 generation in glioma. High-dose combination of vitamin C and radiation has a much more profound cytotoxic effect on primary glioblastoma multiforme cells compared to normal astrocytes. Control trials are needed to validate the use of vitamin C and standardization of the doses of vitamin C in the treatment of patients with glioma.
Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
Authors: Schatz Michael J. , Wilkins Carl S. , Otero-Marquez Oscar , Chui Toco Y. P. , Rosen Richard B. , Gupta Meenakashi
Published: December 2021

While plasmapheresis is well known to significantly improve both retinal findings and systemic manifestations associated with Waldenstrom macroglobulinemia, few reports exist documenting changes in optical coherence tomography angiography (OCT-A). The authors present a case of a patient with Waldenstrom macroglobulinemia who had resolution of white-centered peripheral retinal lesions and parafoveal outer nuclear layer hyperreflective material following plasmapheresis. Applying image analysis software to before and after OCT-A images, the authors were able to show an objective decrease in retinal capillary and large vessel density following plasmapheresis. This technique can be used to guide treatment and surveillance for patients with hyperviscosity-related retinopathy.
Systematic Evaluation of the Effect of Bedside Ward Round Checklist on Clinical Outcomes of Critical Patients
Authors: Wen Xuemin , Wen YuXiang , Wang Ge , Li Hui , Zuo Hong
Published: December 2021

Objective. To systematically evaluate the effect of bedside ward round checklists on the clinical outcomes of critical patients and thus provide a scientific and rational basis for decision-making in its clinical application. Methods. PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang databases were searched to collect the literature studies about randomized controlled trials (RCTs) and cohort studies involving the effect of bedside ward round checklists on the clinical outcomes of critical patients, and the retrieval time limit was from the establishment of the database to August 2019. After two researchers independently screened the literature studies, extracted the literature data, and evaluated the risk of bias in included studies, meta-analysis was carried out by using Stata 12.0 software. Results. Two RCTs and nine cohort studies were included in this study. The results of meta-analysis showed that compared with the ordinary bedside ward round, the application of checklist in bedside ward round could shorten the ICU hospitalization time (standardized mean difference (SMD) = – 0.37, 95% CI (– 0.78, 0.04),

P

 ≤ 0.001) and mechanical ventilation time (SMD = – 0.24, 95% CI (– 0.44, −0.04),

P

 = 0.037) and reduce the incidence of ventilator-associated pneumonia (VAP) (SMD = 0.61, 95% CI (0.38, 0.99),

P

 = 0.057) in critical patients. However, there were no significant differences in central venous catheter (CVC) retention time and incidence and mortality of deep venous thrombosis (DVT) between ordinary ward round and bedside ward round checklist. Conclusion. The existing evidence shows that compared with the ordinary ward round, the application of bedside ward round checklists can shorten ICU hospitalization time and mechanical ventilation time and reduce VAP incidence and ICU mortality in critical patients. However, due to the limitations of the quality of the included studies, the above conclusions need to be verified with more high-quality studies.
[Retracted] Dynamic Systems Enhanced by Electronic Circuits on 7D
Authors: Abdullah Hamad Abdulsattar , Lellis Thivagar M. , Bader Alazzam Malik , Alassery Fawaz , Mahmood Khalil Muayyad , Ramesh V. , Meraf Zelalem , Kumar Vishal
Published: December 2021

Hybrid synchronization is one of the most significant aspects of a dynamic system. We achieve nonlinear control unit results to synchronize two comparable 7D structures in this study. Many dynamic systems are directly connected to health care and directly enhance health. We employed linearization and Lyapunov as analytical methods, and since the linearization method does not need updating the Lyapunov function, it is more successful in achieving synchronization phenomena with better outcomes than the Lyapunov method. The two methods were combined, and the result was a striking resemblance to the dynamic system’s mistake. The mathematical system with control and error of the dynamic system was subjected to digital emulation. The digital good outcomes were comparable to the two methods previously stated. We compared the outcomes of three hybrid synchronizations based on Lyapunov and linearization methods. Finally, we used the existing system, presenting it in a new attractor and comparing the findings to those of other similar systems.
Correlation Analysis of Chaige Qinlian Decoction and Acupuncture Combined Intervention on Prognosis of Children with Pneumonia
Authors: Sun Qi , Yu Hanshu , Shang Yun , Cao Yan
Published: December 2021

Background. Traditional Chinese medicine (TCM) treatment is of great importance to improve the clinical symptoms of children with pneumonia, and this study was conducted in this context. Methods. The clinical data of 82 child patients with pneumonia admitted to our hospital from February 2019 to February 2020 were retrospectively analyzed, and the patients were divided into the conventional group and the combined group according to the parity of their admission numbers, with 41 cases each. Conventional Western medicine therapy was given to children in the conventional group, and on this basis, acupuncture combined with Chaige Qinlian decoction was performed on children in the combined group, so as to evaluate the clinical application value of combined treatment and analyze its relationship with prognosis by recording the recovery time of each symptom, serum indicators, and immune indicators. Results. Children in the combined group had significantly shorter recovery time of each symptom and lower mean CPIS scores after treatment than the conventional group (

P
<
0.001

); the TCM symptom scores at T1 (1 d after treatment), T2 (3 d after treatment), T3 (7 d after treatment), and T4 (10 d after treatment) of children in the combined group were significantly higher than those in the conventional group (

P
<
0.05

); various immune indicators of the combined group before and after treatment were significantly different (

P
<
0.001

), and after treatment, the combined group obtained significantly higher IgG levels and lower IgA, complement C3, and complement C4 levels than the conventional group (

P
<
0.001

); and there was a positive correlation between the CPIS scores and serum IL-8, IL-6, and CRP levels at the first day (r = 0.706, 0.712, 0.734,

P
<
0.001

). Conclusion. Acupuncture combined with Chaige Qinlian decoction can effectively shorten the course of disease, reduce the levels of serum inflammatory factors, and improve the immune function of body for child patients with pneumonia. Serum IL-8, IL-6, and CRP levels in child patients can reflect the clinical prognosis, with higher levels indicating worse prognosis.
A Hybrid Model Method for Accurate Surface Deformation and Incision Based on FEM and PBD
Authors: Tan Shijie , Zhou Hongjun , Zheng Jinjin
Published: December 2021

In some simulations like virtual surgery, an accurate surface deformation method is needed. Many deformation methods focus on the whole model swing and twist. Few methods focus on surface deformation. For the surface deformation method, two necessary characteristics are needed: the accuracy and real-time performance. Some traditional methods, such as position-based dynamics (PBD) and mass-spring method (MSM), focus more on the real-time performance. Others like the finite element method (FEM) focus more on the accuracy. To balance these two characteristics, we propose a hybrid mesh deformation method for accurate surface deformation based on FEM and PBD. Firstly, we construct a hybrid mesh, which is composed of a coarse volume mesh and a fine surface mesh. Secondly, we implement FEM on coarse volume mesh and PBD on fine surface mesh, and the deformation of fine surface mesh is constrained by the displacement of the coarse volume mesh. Thirdly, we introduced a small incision process for our proposed method. Finally, we implemented our method on a simple deformation simulation and a small incision simulation. The result shows an accurate surface deformation performance by implementing our method. The incision effect shows the compatibility of our proposed method. In conclusion, our proposed method acquires a better trade-off between accuracy and real-time performance.
Incoherent Integration Detection Method of Airborne Phased Array Radar in a Multipath Environment
Authors: Hu Yili , Zhao Yongbo , Chen Sheng
Published: December 2021

Airborne phased array radar (PAR) suffers from multipath problems when flying over a calm sea surface. The existence of a multipath phenomenon will cause the electromagnetic echo of the same target to be reflected back to the airborne PAR from two paths, namely, direct path (DP) and multipath. Compared with the ground-based radar, the target echo received by airborne PAR in the multipath environment has two important characteristics: one is that the DP signal and the multipath signal exist in different range bins, and the other is that the radar cross section (RCS) in the DP direction may be smaller than that in the multipath direction. Considering these two characteristics, this paper first proposes a target pairing algorithm for matching the DP range and multipath range of the same target in signal detection, and then, combined with the cell-averaging constant false alarm rate (CA-CFAR) detection model, an incoherent integration detection method for airborne PAR in the multipath environment is proposed. In the target pairing process, the geometric structure relationship of the airborne PAR model can be fully utilized. After a successful target pairing process, the energy of the multipath signal will be incoherently accumulated into the corresponding DP range bin, so as to improve the probability of DP range bin data passing the detection threshold. In essence, the proposed method makes full use of multipath energy to improve the detection capability of airborne PAR in the multipath environment. Finally, the detection probability of the proposed method is given, and the detection performance is analyzed.
The Use of Honeybee Hives May Boost Yields of Some Crops in Nepal
Authors: Devkota Kedar , Rijal Prashant , Fernando dos Santos Charles
Published: December 2021

Many pollination-dependent crops worldwide need bees for the highest productivity. If the crops are not pollinated, a pollination deficit will result. Consequently, low yields of fruit set and seed set of cultivated plants may be expected. Here, we evaluated how pollination with honeybee (Apis mellifera) hives may affect the production of the bittergourd (Momordica charantia), buckwheat (Fagopyrum esculentum), and mustard (Brassica campestris) in tons or quintal per hectare in Nepal. Our experimental design involved three treatments in blocks within selected areas: (i) the effect of the honeybees alone (caged with beehives), (ii) free insect access under natural field conditions, and (iii) blocks restraining insect access (caged without beehives). We also assessed the flower visiting insects within crops using pan traps and identifying insect orders. We found that the productivity of bittergourd, buckwheat, and mustard significantly increased in the treatments with beehives inside the cage. To a lesser extent, the treatment with free access to the flying insects enhanced the production of the selected crops. Proportionally, Hymenoptera (mainly bees) was the most common taxon within bittergourd, buckwheat, and mustard crops, followed by Diptera and Lepidoptera. Hence, the provision of beehives in cultivated areas such as those evaluated here could be considered as a complementary strategy for supporting the long-term productivity of these crops in Nepal.
The Normative Study of Acoustic and Aerodynamic Characteristics of Voice among Healthy Adult Turkish Speaker Population
Authors: Şen Ayşegül Zencir , Toğram Bülent
Published: December 2021

Phonatory Aerodynamic System (PAS Model 6600) is an evaluation instrument that assesses the effectiveness of surgical interventions, treatments, and therapy for voice disorders. It can be used for the assessment of voice disorders by supporting other perceptual and instrumental methods. It is important to establish normative data, because the use of appropriate norms is necessary for diagnostic and descriptive accuracy. Therefore, this study is aimed primarily at establishing adult normative databases for phonatory aerodynamic measures obtained with the KayPENTAX PAS Model 6600 among healthy adult Turkish speakers and then examining the effect of age, gender, and age‐gender interaction variables on these measures. The contribution of the study is considered so important since it will generate normative data for all measurements—except the mean pitch—by the five protocols of PAS for the first time. Two hundred and six healthy Turkish speakers with normal voice (106 women and 100 men) were included in the study and stratified into three age groups. Forty‐five phonatory aerodynamic measures across five PAS protocols (vital capacity, maximum sustained phonation, comfortable sustained phonation, variation in sound pressure level, and voicing efficiency) were collected. Age, gender, and age‐gender interaction variables were analyzed for 45 PAS parameters. Significant gender and age effect was found for 30 and 19 variables, respectively. Gender‐age interaction together was observed for only 6 parameters. Significant differences were not found for the remaining 10 parameters. Significant age and gender effects were observed for 35 phonatory and aerodynamic measures which are essential part of the objective clinical assessment of voice. Consequently, normative data used as reference in voice assessment should be generated according to age and gender differences.
On the Reformulated Second Zagreb Index of Graph Operations
Authors: Maji Durbar , Ghorai Ganesh , Gaba Yaé Ulrich
Published: December 2021

Topological indices (TIs) are expressed by constant real numbers that reveal the structure of the graphs in QSAR/QSPR investigation. The reformulated second Zagreb index (RSZI) is such a novel TI having good correlations with various physical attributes, chemical reactivities, or biological activities/properties. The RSZI is defined as the sum of products of edge degrees of the adjacent edges, where the edge degree of an edge is taken to be the sum of vertex degrees of two end vertices of that edge with minus 2. In this study, the behaviour of RSZI under graph operations containing Cartesian product, join, composition, and corona product of two graphs has been established. We have also applied these results to compute RSZI for some important classes of molecular graphs and nanostructures.
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
Authors: Liao Chengheng , Glodowski Cherise Ryan , Fan Cheng , Liu Juan , Mott Kevin R. , Kaushik Akash , Vu Hieu , Locasale Jason W. , McBrayer Samuel K. , DeBerardinis Ralph J. , Perou Charles M. , Zhang Qing
Published: December 2021

Metabolic dysregulation is a prominent feature in breast cancer, but it remains poorly characterized in patient tumors. In this study, untargeted metabolomics analysis of triple-negative breast cancer (TNBC) and patient with estrogen receptor (ER)–positive breast cancer samples, as well as TNBC patient-derived xenografts (PDX), revealed two major metabolic groups independent of breast cancer histologic subtypes: a “Nucleotide/Carbohydrate-Enriched” group and a “Lipid/Fatty Acid-Enriched” group. Cell lines grown in vivo more faithfully recapitulated the metabolic profiles of patient tumors compared with those grown in vitro. Integrated metabolic and gene expression analyses identified genes that strongly correlate with metabolic dysregulation and predict patient prognosis. As a proof of principle, targeting Nucleotide/Carbohydrate-Enriched TNBC cell lines or PDX xenografts with a pyrimidine biosynthesis inhibitor or a glutaminase inhibitor led to therapeutic efficacy. In multiple in vivo models of TNBC, treatment with the pyrimidine biosynthesis inhibitor conferred better therapeutic outcomes than chemotherapeutic agents. This study provides a metabolic stratification of breast tumor samples that can guide the selection of effective therapeutic strategies targeting breast cancer subsets. In addition, we have developed a public, interactive data visualization portal (http://brcametab.org) based on the data generated from this study to facilitate future research.

Significance:

A multiomics strategy that integrates metabolic and gene expression profiling in patient tumor samples and animal models identifies effective pharmacologic approaches to target rapidly proliferating breast tumor subtypes.
Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non–small Cell Lung Cancer PDX Models with Driver Genetic Alterations
Authors: Jo Hitomi , Yagishita Shigehiro , Hayashi Yoshiharu , Ryu Shoraku , Suzuki Mikiko , Kohsaka Shinji , Ueno Toshihide , Matsumoto Yuji , Horinouchi Hidehito , Ohe Yuichiro , Watanabe Shun-ichi , Motoi Noriko , Yatabe Yasushi , Mano Hiroyuki , Takahashi Kazuhisa , Hamada Akinobu
Published: December 2021

Patient-derived xenografts (PDX) can adequately reflect clinical drug efficacy. However, the methods for evaluating drug efficacy are not fully established. We selected five non–small cell lung cancer (NSCLC) PDXs with genetic alterations from established PDXs and the corresponding molecular targeted therapy was administered orally for 21 consecutive days. Genetic analysis, measurement of drug concentrations in blood and tumors using LC/MS-MS, and analysis of drug distribution in tumors using matrix-assisted laser desorption/ionization mass spectrometry were performed. Fifteen (20%) PDXs were established using samples collected from 76 patients with NSCLC with genetic alterations. The genetic alterations observed in original patients were largely maintained in PDXs. We compared the drug efficacy in original patients and PDX models; the efficacies against certain PDXs correlated with the clinical effects, while those against the others did not. We determined blood and intratumor concentrations in the PDX model, but both concentrations were low, and no evident correlation with the drug efficacy could be observed. The intratumoral spatial distribution of the drugs was both homogeneous and heterogeneous for each drug, and the distribution was independent of the expression of the target protein. The evaluation of drug efficacy in PDXs enabled partial reproduction of the therapeutic effect in original patients. A more detailed analysis of systemic and intratumoral pharmacokinetics may help clarify the mode of action of drugs. Further development of evaluation methods and indices to improve the prediction accuracy of clinical efficacy is warranted.
Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates
Authors: Khera Eshita , Dong Shujun , Huang Haolong , de Bever Laureen , van Delft Floris L. , Thurber Greg M.
Published: December 2021

After several notable clinical failures in early generations, antibody–drug conjugates (ADC) have made significant gains with seven new FDA approvals within the last 3 years. These successes have been driven by a shift towards mechanistically informed ADC design, where the payload, linker, drug-to-antibody ratio, and conjugation are increasingly tailored to a specific target and clinical indication. However, fundamental aspects needed for design, such as payload distribution, remain incompletely understood. Payloads are often classified as “bystander” or “nonbystander” depending on their ability to diffuse out of targeted cells into adjacent cells that may be antigen-negative or more distant from tumor vessels, helping to overcome heterogeneous distribution. Seven of the 11 FDA-approved ADCs employ these bystander payloads, but the depth of penetration and cytotoxic effects as a function of physicochemical properties and mechanism of action have not been fully characterized. Here, we utilized tumor spheroids and pharmacodynamic marker staining to quantify tissue penetration of the three major classes of agents: microtubule inhibitors, DNA-damaging agents, and topoisomerase inhibitors. PAMPA data and coculture assays were performed to compare with the 3D tissue culture data. The results demonstrate a spectrum in bystander potential and tissue penetration depending on the physicochemical properties and potency of the payload. Generally, directly targeted cells show a greater response even with bystander payloads, consistent with the benefit of deeper ADC tissue penetration. These results are compared with computational simulations to help scale the data from in vitro and preclinical animal models to the clinic.
What Can We Learn from the Parents of Children Affected with Mucopolysaccharidosis Type III-A in Israel?
Authors: Liber Shiri , Staretz-Chacham Orna , Kishon Mor , Pode-Shakked Ben , Chorin Odelia , Kneller Katya , Anikster Yair , Mangisto Geto , Saada Ann , Raas-Rothschild Annick
Published: December 2021

Sanfilippo Syndrome, or mucopolysaccharidosis type III (MPS III), is a group of autosomal-recessive lysosomal storage disorders leading to tissue accumulation of heparan sulfate. MPS III is caused by deficiency in one of 4 enzymes involved in lysosomal degradation of heparan sulfate. Based on the relevant enzyme deficiency, 4 types have been recognized. MPS III constitutes a progressive neurodegenerative and systemic disorder. Parents of children diagnosed with MPS III were interviewed using a retrospective questionnaire based on the known clinical manifestations of MPS III. Eight patients from 4 unrelated families of varied ethnic origin were included. All children were diagnosed with MPS type III-A. Average age at diagnosis was 6.1 years. The most common early clinical manifestations leading to parental suspicion of illness were speech delay and coarse facial features. All children were reported to have global developmental delay, sleep disorders, recurrent infections, hyperactivity, and decreased hearing. The time from first medical inquiry until diagnosis was over 2 years on average, consistent with the delay in diagnosis described in the literature. MPS III children frequently undergo early and repeated ear, nose and throat surgeries, thus we suggest that a high index of suspicion is warranted in relevant clinical circumstances.
Práticas de leitura em Língua Portuguesa a partir da BNCC: em que se fundamentam e como realizá-las em sala de aula?
Authors: Rossi Maria Aparecida Garcia Lopes
Published: December 2021

A Base Nacional Comum Curricular – BNCC (BRASIL, 2018) prescreve práticas de leitura que devem ser implementadas na educação básica brasileira. No entanto, não explicita as bases teóricas em que fundamenta o Eixo Leitura em Língua Portuguesa, de forma que faltam subsídios para o aprimoramento teórico do professor, para o planejamento e para a implementação das práticas prescritas. Esta pesquisa teve o objetivo de investigar o Eixo Leitura da BNCC, Língua Portuguesa, da etapa do 6º ao 9º ano, no que se refere à proposta do documento e às suas bases teóricas e, ainda, às possibilidades didáticas dos principais conceitos envolvidos. Metodologicamente, é uma pesquisa qualitativa, sendo a primeira etapa do tipo documental, e a segunda, bibliográfica. Os resultados oferecem subsídios para o aprimoramento teórico do professor e para o planejamento de atividades de leitura teoricamente bem fundamentadas.
Hidrogeoquímica do Sistema Aquífero Cristalino no sul do estado do Espírito Santo – Brasil
Authors: Neves Mirna Aparecida , Oliveira Matheus Serri Moulin de , Calegari Salomão Silva , Bertolo Reginaldo Antonio , Hirata Ricardo César Aoki , Caxito Fabrício de Andrade
Published: December 2021

A demanda por água subterrânea no estado do Espírito Santo vem crescendo consideravelmente frente aos eventos de escassez que marcaram os últimos anos. No entanto, a carência de conhecimentos hidrogeológicos compromete a locação de poços e a previsão da qualidade das águas, especialmente nos terrenos de rochas cristalinas. Este trabalho teve como objetivo uma avaliação hidrogeoquímica e da qualidade da água subterrânea do Sistema Aquífero Cristalino na Bacia Hidrográfica do Rio Itapemirim (BHRI), situada no sul do estado do Espírito Santo, descrevendo as variações composicionais e os condicionantes que influenciam a qualidade da água subterrânea. A compartimentação litológica e geomorfológica da bacia e as condições climáticas são os fatores que influenciam na hidrogeoquímica em escala regional, enquanto o uso e a ocupação do solo exercem influência pontual. Na porção da Alta BHRI, com relevo acidentado e predomínio de atividades agropecuárias, ocorrem principalmente águas bicarbonatadas cálcicas e bicarbonatadas cálcicas-magnesianas, pouco mineralizadas comparativamente à porção central da bacia, com composição química governada essencialmente pelo intemperismo das rochas silicáticas. Embora sejam águas de boa qualidade, alterações locais podem ocorrer em razão do nitrato proveniente de atividades antrópicas. Na porção da Média BHRI, com menores altitudes e relevo mais suave, as águas são predominantemente bicarbonatadas sódicas e cloretadas sódicas, com maior mineralização em relação à porção alta da bacia em razão da contribuição de rochas silicáticas em associação com litotipos carbonáticos, como mármores e calciossilicáticas. Nessa porção da bacia, as condições climáticas, com temperaturas mais altas e menor umidade do ar na área central da bacia, topograficamente mais rebaixada, também podem contribuir com o enriquecimento mineral em decorrência da evaporação da água que infiltra
Multiple cues guarantee successful predation by a Neotropical wasp
Authors: Mendes-Silva Isamara , Queiroga Drielly , Calixto Eduardo S. , Torezan-Silingardi Helena M. , Del-Claro Kleber
Published: December 2021

Predatory social wasps are well studied in several aspects; however, foraging behaviour, especially that which takes place away from the nest at often unpredictable locations, or specialized behaviours to find and subdue prey are not well understood. In the Brazilian tropical savanna, the Polistinae wasp Brachygastra lecheguana is specialized in preying on some endophytic weevil larvae which develops inside floral buds. We hypothesized that these wasps utilize a combination of different mechanisms such as visual, chemical (odour) and possible tactile cues to find the weevil larvae. Using a combination of experimental manipulations (visual; chemical; visual/chemical) we tested the wasp’s ability to detect the endophytic larvae in the field. Additionally, we checked the ability of this wasp to detect vibrations produced by the weevils inside the buds. Our results suggest that the B. lecheguana wasp utilizes a sequence of eco-physiological mechanisms to find the endophytic larva inside floral buds: sight, smell, and perhaps touch. The use of multiple cues by this wasp guarantees such a high rate of predation on endophytic beetles that the wasp may have positive implications (reduction in weevils’ infestation) for the future of the host plant’s reproduction.
‘Becoming Black’
Authors: Tewolde Amanuel Isak
Published: December 2021

Little is known about racial identity claims of African migrants living in Israel who originate from countries where race is not a dominant identity marker. This article examines how Eritrean migrants, coming from a country where race-based social organisation is not prevalent, strategically adopted ‘Black’ as their identity marker in Israel. Online newspaper reports and conversational interviews with four Eritrean migrants were used as sources of data. During various anti-deportation protests, Eritrean migrants held signs with slogans referring to themselves as Black. Some of the slogans include: ‘Do Black lives matter in Israel?’, ‘Black or White I am human’, ‘Deported to death because I am Black’, and ‘Now I am White, will you deport me?’ I argue that for first generation Eritrean migrants in Israel, Black racial identity was adopted strategically as a political identity of social mobilisation and resistance in the face of a racialised and exclusionary migration policy.
World-Making at the Margins
Authors: Marquez Arturo
Published: December 2021

Transnational social networks are vital to West Africans in managing relationships but also in ascertaining viable ways of being and belonging in the diaspora. Drawing from ethnographic fieldwork in the metropolitan area of Barcelona, Catalonia, Spain, this paper examines the ‘Baay Faal paradox’ to address sites of contention in West African endeavours to bind a sense of self to transnational social networks. I propose urban world-making practices that sustain connections to transnational social networks from the margins of these relations signal what I am calling ‘affective tethering.’ The term ‘tethering’ in my analysis foregrounds an imagined distance between normative models of practice and purported deviations that result in precarious, unstable and patchy connections to transnational social networks. This approach sheds light on the complex relationship between a person’s sense of self and the transnational social networks that inform ideas of personhood in the context of global mobility and settlement.
Al-Kindī’s Two-Volume Compendium of Aristotelian Philosophy: Al-Falsafa al-Ūlā and al-Falsafa al-Dākhila
Authors: Stewart Devin J.
Published: December 2021

This study argues that the first two titles listed in the bibliography of Abū Yūsuf Yaʿqūb b. Isḥāq al-Kindī (d. ca. 259/873) presented in the Fihrist of Ibn al-Nadīm (d. 380/990) – his well-known work al-Falsafa al-ūlā (First Philosophy), on metaphysics, and a lost work entitled al-Falsafa al-dākhila (Internal Philosophy) – form an intentional pair. Together, they presented an epitome of Aristotle’s collective works on philosophy, including an outline of metaphysics in al-Falsafa al-ūlā and a discussion of detailed questions of logic, physics, psychology, and metaphysics in al-Falsafa al-dākhila. Drawing primarily on al-Kindī’s work On the Quantity of Aristotle’s Books, the study suggests several emendations to the full title of al-Falsafa al-dākhila as recorded in the Fihrist of Ibn al-Nadīm.
Redescription of C. Willmann’s Holarctic species of the genus Trhypochthonius (Acari: Oribatida: Trhypochthoniidae)
Authors: SZYWILEWSKA-SZCZYKUTOWICZ ANETTA , OLSZANOWSKI ZIEMOWIT
Published: December 2021

Trhypochthonius nigricans and T. cladonicolus are redescribed on the basis of type specimens originating from C. Willmann’s collection and comparative material from Poland, Canada and the USA. The taxonomic importance of some morphological characters is analysed. Shape of the sensillus does not seem to be a good diagnostic character in the genus Trhypochthonius. Trhypochthonius sphagnicolus is recognized as a junior synonym of T. nigricans and T. cladonicolus is noted for the first time from the North America.
Pseudecheneis maurus, a new species of glyptosternine catfish (Teleostei: Sisoridae) from Central Vietnam
Authors: NG HEOK HEE , TAN HEOK HUI
Published: December 2021

A new species of sisorid catfish, Pseudecheneis maurus, is described from the Song Thuy Loan drainage in Central Vietnam. Pseudecheneis maurus can be distinguished from congeners in having a combination of a very short adipose-fin base (1.2 times length of anal-fin base vs. 1.5–2.0 times; 15.7% SL vs. 17.6–30.6), thoracic adhesive apparatus with sulcae not meeting at midline and the absence of distinct pale spots on the body.
Contributions to the knowledge of Neotropical Castianeirinae (Araneae: Corinnidae): redescription of Castianeira spinipalpis Mello-Leitão, 1945, with first description of the male, and description of a new Myrmecotypus O. Pickard-Cambridge, 1894 from the Bolivian Moxos plains
Authors: PETT BROGAN L. , PERGER ROBERT
Published: December 2021

Two Neotropical species of the subfamily Castianeirinae are treated herein. Castianeira spinipalpis Mello-Leitão, 1945 was described from a single female specimen; we provide a redescription of the female and the male is described for the first time. The species is newly recorded from Paraguay and Bolivia. Also, Myrmecotypus rubioi sp. nov. is described from the Bolivian Moxos plains, a tropical savanna ecoregion of the Beni department of northern Bolivia. The new species can be distinguished from others in the genus by having tibia I spination 3-2, coxa II whitish (the remainder dark), and a unique male palpal embolus with two broad embolic discs basal to the embolus tip.
Contribution to the genus Pararrhynchium de Saussure (Hymenoptera: Vespidae: Eumeninae), with description of two new species from Vietnam
Authors: NGUYEN LIEN THI PHUONG , TRAN NGAT THI , BUI DIEN TRONG , LJUBOMIROV TOSHKO
Published: December 2021

Two new species of the genus Pararrhynchium de Saussure are described as new to science: P. simsanum Nguyen and Tran, sp. nov. from Bat Xat, Lao Cai province, and P. sparsum Nguyen and Ljubomirov, sp. nov. from Ham Yen, Tuyen Quang province. An updated key to all known species of the genus is also presented.
Restoration Simulation of Image Quality Degradation of Nanosensors Based on Virtual Reality
Authors: Wang Jiajie , Zeng Junmei
Published: December 2021

The texture complexity of traditional sensor image degradation restoration methods is high and the restoration effect is reduced. For this reason, a virtual reality-based image quality degradation recovery method for nanosensors is designed in this paper. First, the image quality degradation
model of nanometer sensor is constructed based on virtual reality technology. Then, the noise characteristics of the degraded image are analyzed. On the premise of retaining the original image information, the diffusion coefficients in the vertical and horizontal directions are calculated
to obtain the expression of adaptive filter (ADF) in the image with noise, so as to complete the image denoising process. On the basis of texture complexity analysis, singular value decomposition detection and alpha channel calculation are completed, and image quality degradation recovery
of nanosensor is achieved through synthesis operation. The experimental results show that the texture complexity of the recovered images is lower than 0.54, the average absolute error percentage of the recovered images is only 10%, and the P-R value is high, which fully demonstrates
the effectiveness of the offered procedure.
Deep Eye Clouds in Tropical Cyclone Trami (2018) during T-PARCII Dropsonde Observations
Authors: Hirano Soichiro , Ito Kosuke , Yamada Hiroyuki , Tsujino Satoki , Tsuboki Kazuhisa , Wu Chun-Chieh
Published: December 2021

The sporadic formation of short-lived convective clouds in the eye of Tropical Cyclone (TC) Trami (2018) is investigated using dropsonde data and simulation results from a coupled atmosphere–ocean model. According to the satellite data, top height of the convective clouds exceeds 9 km above mean sea level, considerably taller than that of typical hub clouds (2–3 km). These clouds are located 10–30 km away from the TC center. Hence, these convective clouds are called deep eye clouds (DECs) in this study. The dropsonde data reveal an increase in relative humidity in the eye region during the formation of DECs. Short-lived convective clouds are simulated up to the middle troposphere in the eye region in the coupled model. Investigation of thermodynamic conditions shows a weakened low-level warm core and associated favorable conditions for convection in the eye region during the formation of DECs. DECs are formed after the weakening and outward displacement of convective heating within the eyewall. To elucidate the influence of the changes in convective heating within the eyewall on the formation of DECs, we calculate secondary circulation and associated adiabatic warming induced by convective heating within the eyewall using the Sawyer–Eliassen equation. In the eye region, weakening of subsidence and associated vertical potential temperature advection is observed as DECs are formed. This suggests that the weakening and outward displacement of convective heating within the eyewall create favorable conditions for the sporadic formation of DECs.
Frailty Score as a Predictor of Outcomes in Geriatric Patients with Isolated Hip Fractures
Authors: Sang Whiyie A. , Durrani Hamza , Liu Huazhi , Clark Jason M. , Ferber Laurence , Hagan Joshua , Richards Winston , Taylor Dana , Watson Carrie , Ang Darwin
Published: December 2021

Background

Isolated hip fractures (IHFs) are a cause of morbidity and mortality in the geriatric population aged >65 years. Frailty has been identified as a determinant for patient outcomes in other surgical specialties. The purpose of this study is to determine if frailty severity is a predictor of outcomes in IHF in the geriatric population.

Methods

This is a retrospective study in a state and ACS Level 2 trauma center. Patients with IHF were reviewed between January 2018 and January 2020. Primary outcome was in-patient mortality. Secondary outcomes include perioperative outcome measures such as UTI, HCAP, DVT, readmission, length of stay, ICU length of stay, nutritional status, and discharge destination. Patients were stratified into mild (1-2), moderate (3-5), and severe (5-7) frailty using the Rockwood Frailty Score (RFS). Clinical characteristics and outcomes were analyzed.

Results

We identified 470 patients with IHF who were stratified by mild (N=316), moderate (N-123), and severe (N=31) frailty. Frailty worsened with increasing age (P < .0001). Those who were less frail were more likely discharged home (P < .04). Severely frail patients were more likely discharged to hospice (P < .01). Severely frail patients also were more likely to develop DVT (P < .04) and have poorer nutritional status (P < .02). There were no differences among groups for in-patient mortality.

Conclusion

Severely frail patients are more likely to be malnourished at baseline and be discharged to hospice care. The RFS is a reliable objective tool to identify high-risk patients and guide goals of care discussion for operative intervention in isolated traumatic hip fractures.
How Can Schools Increase Students’ Hopefulness Following the Pandemic?
Authors: Barnett Bruce G.
Published: December 2021

The COVID-19 pandemic has adversely affected the academic progress and wellbeing of many students, resulting in a greater sense of hopelessness and despair. These consequences are particularly devastating for many children living in urban communities, where poverty and a lack of resources prevent them from accessing high-quality learning, health care, and social programs. To understand the enormity of the problems associated with the growing hopelessness of our school-aged children, this article describes the factors affecting hope, how schools can foster hope, the skills and mindsets educators need to instill hope, and the positive outcomes of producing more hopeful students.