bluuebunny/crossref_metadata_2025 huggingface dataset:
The osteoprotective effect of melittin acupoint injection on CIA mice based on the gut-joint axis
Authors: Chen Fen , Liu Fenfang , Zhong Guangen , Xi Weizhe , Gao Shan , Lai Meilian , He Qiting , Zhang Jiping , Yang Le , Chen Ying , Yang Lu
Published: September 2023

Objective
The intestinal mucosal barrier and gut microbiota metabolism play an important role in the disease progression and treatment of rheumatoid arthritis. Melittin acupoint injection has been improved and developed from traditional bee needle therapy, and has good anti-RA efficacy. However, its potential therapeutic mechanism is still unclear. We aimed to study the effects of MAI on the efficacy, intestinal mucosal barrier, and gut microbiota metabolism of collagen induced arthritis mice.
Methods
DBA/1 mice were randomly divided into normal group, model group, methotrexate group, and melittin acupoint injection group. collagen induced arthritis mice were established using enhanced immunotherapy, and melittin acupoint injection intervention was given every 2 days for a total of 28 days of treatment. Closely observe the development of mouse arthritis, detect serum inflammatory factors using ELISA, evaluate the structure of mouse knee and intestinal tissues using histopathological staining, detect the expression of target proteins in bone and intestinal tissues using WB method, and detect differential metabolites in feces using LC-MS technology.
Results
Compared with the normal group, the arthritis index of the model group mice showed a significant upward trend after strengthened immunization; The pathological staining results of joint tissue showed proliferation of synovium, infiltration of inflammatory cells, significant formation of pannus and erosion of joint cartilage, and a significant increase in osteoclasts; Serum pro-inflammatory factors IL-1β, IL-17 and IL-23 significantly increased, while the anti-inflammatory factor TGF-β1 showed a decreasing trend. The expression of proteins related to OC differentiation was significantly increased. Pathological staining of intestinal tissue showed disruption of the intestinal mucosal barrier, significantly reduced expression of tight junction proteins, and a significant increase in serum intestinal permeability indicators DAO, D-LA, and Zonulin. Fecal metabolomics analysis showed metabolic disorders with a significant decrease in butyrate levels; Compared with the model group, the melittin acupoint injection group showed significant improvement in the above indicators, and the difference was statistically significant.
Conclusion
melittin acupoint injection had a significant therapeutic effect on Rheumatoid arthritis, improving joint inflammation and joint structural damage. Its mechanism of action may increase fecal butyric acid content by acting on fecal microbial metabolism, regulating butyric acid metabolism pathways, protecting the intestinal mucosal barrier, controlling inflammation, and thus exerting therapeutic effects on Rheumatoid arthritis.
Analysis of multipacting threshold sensitivity to the random distributions of the secondary electron yield parameters
Authors: Kazemi Firozeh , Mostajeran Maryam , Romanov Gennady
Published: September 2023

The way multipacting develops, depends strongly on the secondary emission property of the surface material. The knowledge of secondary electron yield is crucial for accurate prediction of the multipacting threshold. Variations in secondary electron yield parameters from experimental measurements create uncertainty, stemming from handling and surface preparation, and these uncertainties significantly affect multipacting threshold predictions. Despite their significance, the previous studies on the multipacting phenomenon did not adequately address the effect of an assumed random distribution of the secondary emission parameters on the multipacting threshold. Therefore, this paper aims to provide a comprehensive statistical study on how the different random distributions of the secondary emission parameters and, as a result, the uncertainty in the secondary electron yield affect multipacting thresholds. We focus on three commonly used distributions, namely uniform, normal, and truncated normal distributions, to define the uncertainty of random inputs. We use the chaos polynomial expansion method to determine how much each of the random parameters contributes to the multipacting threshold uncertainty. Additionally, we calculate Sobol sensitivity indices to evaluate the impact of the individual parameters or groups of parameters on the model outputs and study how different random distributions of these parameters affected the Sobol index results.
Improving Alkaline Stress Tolerance in Maize through Seed Priming with Silicon Nanoparticles: A Comprehensive Investigation of Growth, Photosynthetic Pigments, Antioxidants, and Ion Balance
Authors: Alsamadany Hameed , Alharby Hesham F. , Ahmad Zahoor , Al-Zahrani Hassan S. , Alzahrani Yahya M. , Almaghamsi Afaf
Published: September 2023

Silicon nanoparticles (Si NPs) have long been acknowledged for their ability to enhance plant defense against various biotic and abiotic stresses. Maize (Zea mays L.), among the plants known to accumulate Si NPs, is particularly vulnerable to alkaline stress. This study aimed to investigate the effects of different concentrations of Na2CO3 (0 and 75 mM) on maize seeds, along with varying levels of silicon nanoparticles (Si NPs) 0, 1.5 mM, and 3 mM over a 25-day period. The alkaline stress significantly impaired growth parameters, leaf relative water content (LRWC), and the concentrations of photosynthetic pigments, soluble sugars, total phenols, and potassium ions (K+), as well as the potassium/sodium ion (K+/Na+) ratio. However, this stress led to increased levels of soluble proteins, total free amino acids, proline, and sodium ions (Na+), and also elevated the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) in the stressed plants. Conversely, applying silicon nanoparticles through seed-priming mitigated the growth impediments in stressed plants. This intervention resulted in improved LRWC, higher levels of photosynthetic pigments, soluble sugars, soluble proteins, total free amino acids, and potassium ions (K+). Moreover, Si NPs enhanced the activities of SOD, CAT, and POD enzymes. Si supplementation also led to decreased levels of proline and sodium ions (Na+), which in turn facilitated a more favorable adjustment of the K+/Na+ ratio in stressed plants.
Residual Mechanical Properties of Post Fire Steel Rebars
Authors: Eranki Bhargavi , Durga S. Kanaka , malasani potharaju , Eranki Bhargavi
Published: September 2023

Reinforcement steel is a crucial material for buildings utilized extensively in composite construction due to its benefits, including strength, durability and simplicity of availability. One of the major risks that seriously harms a structure and eventually causes it to collapse is fire. The reinforcing steel significantly loses both its intrinsic mechanical qualities and service life as a result of the intensity of fire exposure. The present research work is being conducted to investigate the residual strength of yield, tensile strength and elongation percentage of 16mmᴓ post fire steel reinforcement bars. The sample specimens were collected from failed post fire RC columns from previous experimental work which were exposed to 300,500 and 800oC temperature for 2.0 hour fire duration having 20, 30 and 40mm concrete covers. The impact of temperature and cover of concrete on mechanical characteristics of post fire steel reinforcement is also discussed.
Psychosocial experiences of pregnant women living with HIV in Ibadan, Oyo State
Authors: Akinsolu Folahanmi , Lawale Abisola , Bankole Samuel , Adegbite Zaniab , Adewole Ifeoluwa , Abodunrin Olunike , Olagunju Mobolaji , Ola Oluwabukola , Chukwuemeka Abel , Gambari Aisha , Salako Abideen , Ezechi Oliver
Published: September 2023

Introduction: Pregnancy often intensifies psychological vulnerabilities in women living with HIV (WLHIV) due to increased stressors such as health concerns, infant infection risks, and the management of special neonatal needs like prophylactic antiretroviral care.
Methodology: The study was conducted in four HIV treatment centres with participant selection based on the following criteria: an Edinburgh Postnatal Depression Scale (EPDS) score of 13 or above, gestational age between 14 to 40 weeks, less than five years of antiretroviral therapy (ART) usage, and history of partner conflict. This research forms a more extensive study of stress and depression amongst pregnant and postpartum WLWH. In-depth interviews, ranging from 20 to 40 minutes, were conducted with 26 HIV-positive pregnant women in private rooms within selected antiretroviral clinics from October and December 2022.
Results and Discussion: The study discovered that the support received from healthcare providers concerning ART and Prevention of Mother-To-Child Transmission (PMTCT) practices alleviated women's fear of death and perinatal transmission which bolstered their involvement in HIV care and fostered the birth of children not infected with HIV. Women perceived monogamy as a protective measure against HIV contraction. Participants who reported having partners engaging in unsafe sexual practices expressed anger and blame. The observation of other women with similar experiences aided in coping mechanisms, reaffirming previous findings that knowing someone living with HIV helps to accept their status due to the comfort derived from shared experiences.
Conclusion: Healthcare providers attending to pregnant WLWH can alleviate psychological distress by reinforcing positive coping strategies. These include consistent psychological distress screenings in HIV clinics and relevant mental health evaluations with appropriate care referrals.
Blockchain-Assisted Cross-silo Graph Federated Learning for Network Intrusion Detection
Authors: Shen Hang , Zhou Yanjing , Wang Tianjing , Zhang Yu , Bai Guangwei , Miao Xiaodong
Published: September 2023

In this paper, a blockchain-assisted cross-silo graph federated learning (B-CGFL) framework is presented for large-scale network intrusion detection, aiming to break down barriers among different organizations and achieve a secure and transparent multi-party collaboration ecosystem. The network scenario is divided into multiple regions. Organizations in each region leverage graph neural networks to analyze local network flow topology information and identify traffic types accurately. With cross-silo graph federated learning, coordinators and organizations collaboratively complete the training and updating of global intrusion detection models. Multiple coordinators jointly maintain a chain to improve the global model’s scalability and storage security. Oracle nodes bridge the off-chain data provider and on-chain smart contracts, enabling secure transmission in off-chain model accuracy testing. For fair competition, a reputation-aware model incentive mechanism is designed to improve global model quality. Security analysis confirms that B-CGFL can defend against inference attacks, model plagiarism, and tampering with model test results. Experiments on three challenging datasets ToN-IoT, CSE-CIC-IDS2018, and BoT-IoT demonstrate that compared with benchmark machine learning methods, B-CGFL exhibits superior performance in accuracy and F1-score and facilitates model quality improvement.
Novel PPOX mutations in two variegate porphyria pedigrees
Authors: Lei Shubin , Yang Lu , Zhang Ruixuan , Guan Xin , Zhao Xiuli , Wang Tao
Published: September 2023

Objective
Variegate porphyria (VP) is an autosomal dominant inherited disease caused by mutation of the PPOX gene and impacted activity of the protoporphyrinogen oxidase (PPOX). We report two pedigrees of young women who present VP-related manifestation such as blistering, flushing, scarring, and hyperpigmentation after sunlight exposure. The genetic analysis of PPOX gene was performed.
Methods
Whole exome sequencing was conducted for both probands, followed by poly chain reaction (PCR) to amplify interested region and validate the suspicious mutations. Reverse transcriptive PCR was conducted to explore the impact of intronic mutation on the splicing process.
Results
The genetic analysis revealed two novel mutations: c.82_83delCC:p.Pro28* and c.222 + 2delT in heterozygous state. The first mutation leads to a premature termination of PPOX translation and the second one causes the insertion of intron2 between exon2 and exon3. Both of the probands inherit PPOX mutation from their healthy father.
Conclusions
Our study provides molecular diagnosis for two VP pedigrees and identified two novel PPOX mutations. We propose a hypothesis that the incomplete penetrance of VP in these two cases might be associated with sexuality and hormone level.
Toxocara canis infection in multiple types of animals: ophthalmological and pathological observations
Authors: Zheng Shuxin , Sun Limei , Huang Li , Xie Yue , Ding Xiaoyan
Published: September 2023

Human ocular toxocariasis (OT), caused by pet roundworm Toxocara canis (Nematoda Ascaridoidea), is a worldwide ocular parasitic infection severe threat to eyesight, especially in school-aged children. However, the infection process and pathological mechanism of Toxocara canis on the ocular are difficult to study in human body. This study was designed to explore long-term ocular manifestation in multiple types of animals infected with Toxocara canis, uncovering the specific pathological mechanism, migration pathway of larvae after infection. Three experinment animals including mice, gerbils and rats were selected and infected with Toxocara eggs, and ocular changes were closely observed and recorded for at least 2 months. The ocular infection rate and mortality tended to be stable at 7 day-post-infection (dpi). At 7dpi, the achievement ratio of mice infected with 2000 T. canis eggs (M2k), gerbils infected with 1000 (G1k), 2000 (G2k) and 4000 (G4k) T. canis eggs were higher, respectively 62.5%, 75%, 100% and 100%. Hemorrhagic lesions, mechanical injury of retina and larval migration can be observed after 3dpi. And the larval tissue, the structure disorder and the inflammation could be observed in the pathological sections. In conclusion, the mice infected with 2000 T. canis eggs and gerbils infected with 1000, 2000, 4000 T.canis eggs represented obvious ocular lesions, could be served for long-term observation.
A Cross-Sectional Study on Health-Related Quality of Life, Sleep, and Psychiatric Disorders in Individuals with Pelvic and Acetabulum Fractures
Authors: ALI KHAN AKHTAR , He LINGXIAO , LI Wenkai , Zhang Weikai , Huang Hui
Published: September 2023

Purpose: The purpose of this study is to assess the long-term (4 years) health-related quality of life (HRQOL), sleep disorders, anxiety, depression, and psychiatric disorders in individuals with pelvic and acetabulum fractures through a cross-sectional study design.
Methods: A study was conducted on 265 patients with pelvic and acetabulum fractures from 2018 to 2022. The study investigated factors such as age, gender, cause of injury, hospital stay, blood loss, surgery duration, fracture reduction, surgical procedures, complications, and injury severity. The patient's quality of life was evaluated using EuroQoL-5D, VAS, and MPS, and sleep and psychological disorders were also assessed.
Results: In a 2-year study of 216 patients with pelvic and acetabulum fractures, 6.6% experienced borderline clinical depression and 45.2% reported mild mood disturbance. Anxiety was mild to moderate in 46% of Tile C and posterior acetabulum wall fracture patients. Insomnia and sleep movement disorders were reported by 24.8% and 23.1% of patients, respectively, but no significant correlation was found between fracture types and sleep disorders. Mean MPS and EQ-5D vas scores were 89.68 and 10.04, respectively. Differences in fracture types were revealed through logistic regression analysis, except for two MPS subscales.
Conclusions. We found that 80% of patients with pelvic and acetabular fractures had improved functional outcomes and quality of life. Older patients may experience anxiety and depression, as well as numbness or irritation related to implants. Posterior acetabulum wall fractures and Tile-C pelvic fractures require careful monitoring due to associated mild pain.
Risk Factors for Atrial Fibrillation after Video-assisted Thoracoscopic Surgery for Lung Cancer
Authors: Ruan Yingding , Han Jianwei , Yang Aiming , Ding Qingguo , Xu Jincheng , Zhang Ting
Published: September 2023

Background
This study aimed to analyze risk factors for postoperative atrial fibrillation (POAF) in video-assisted thoracoscopic surgery (VATS) for non-small cell lung cancer (NSCLC) resection.
Methods
A retrospective analysis was performed on a cohort of patients who underwent VATS for NSCLC resection at our hospital between January 2016 to October 2019. Patient demographics, preoperative data, and postoperative outcomes were collected and reviewed. Univariate and multivariate analyses were performed to identify significant risk factors for POAF.
Results
Among 276 NSCLC VATS patients, 29 developed POAF during hospitalization without in-hospital deaths. 25 cases of POAF emerged within the initial three postoperative days. With a cutoff age of 73, exceeding this age resulted in notably higher POAF incidence compared to non-POAF (10 vs. 46, P = 0.045). Additionally, POAF group had significantly more retrieved mediastinal lymph nodes (P = 0.011) and explored node stations (P = 0.005) compared to non-POAF. Intraoperative bleeding volume (P = 0.034) and postoperative pulmonary infections (P = 0.001) were also higher in POAF group. Preoperative hemoglobin levels differed significantly between POAF and non-POAF (P = 0.024). POAF group experienced extended postoperative hospitalization (P = 0.024) and drainage time (P = 0.011) compared to non-POAF. Multivariate analysis identified postoperative pulmonary infection as independent POAF risk factor following NSCLC VATS.
Conclusion
Our study revealed that pulmonary infection was one of the independent risk factors for POAF following VATS in patients with NSCLC. Furthermore, POAF is associated with prolonged drainage time and extended postoperative hospitalization.
Trial Registration
NO
Cellulose reinforced carbon nanocomposite hydrogels for wearable sensors
Authors: meng lingling , ding shijie , li weihao , liu da , liu en
Published: September 2023

he application of hydrogel in the field of wearable flexible sensors has been widely discussed. However, most hydrogels have some defects in mechanics, stability, and self-recovery, which greatly limit their application in flexible sensors. In this paper, carbon nanotube composite hydrogels with good stability and high stretchability were prepared by the one-pot method in water/glycerol binary solvent using acrylamide (AM), cellulose nanocrystals (CNC) and multi-walled carbon nanotubes (MWCNTs) as raw materials. The composite hydrogels were characterized by scanning electron microscopy and Fourier transform infrared, and their mechanics, conductivity, and stability were tested. The results show that when the content of cellulose nanocrystals (CNC) is 1 wt%, the composite hydrogel has a higher elongation at break (650.96%) and a higher tensile strength (0.26 MPa). This is due to the presence of hydrogen bonds, and the conductivity of the composite hydrogel can be improved with the addition of carbon nanotubes (MWCNTs). When 0.04 g of carbon nanotubes (MWCNTs) were added, the conductivity of the composite hydrogel reached 0.244 S/m, showing good conductivity. In addition, the wearable flexible sensor based on the composite hydrogel has a measurement factor of 7.33 (strain 400%), which can detect human movement. Therefore, carbon nanotube composite hydrogels with good stability and high stretchability have broad application prospects in the field of wearable flexible sensors.
Shotgun Metagenomic insights into the Plastisphere microbiome: Unveiling potential for clinical and industrial enzymes production along with plastic degradation
Authors: Saleem Mahnoor , Ali Akhtar , Razzak Safina Abdul , Khawaja Shariqa , Yahya Saira
Published: September 2023

Plastic pollution is one of the most resilient types of pollution, considered a global environmental threat, particularly in the marine environment. This study aimed to identify plastic-degrading bacteria from the plastisphere and their pharmaceutical and therapeutic potential. We collected samples from soil and aquatic plastisphere to identify the bacterial communities using shotgun metagenomic sequencing and bioinformatic tools. Results showed that the microbiome comprised 93% bacteria, 0.29% archaea, and 3.87% unidentified microbes. Of these 93% of bacteria, 54% were proteobacteria, 23.9% were firmicutes, 13% were actinobacteria, and 2.1% were other phyla. We found that the plastisphere microbiome was involved in degrading synthetic and polyhydroxyalkanoate (PHA) plastic, biosurfactant production, and can thrive under high temperatures. However, except Pseudomonas, no association existed between thermophiles, synthetic plastic or PHA degraders, and biosurfactant-producing bacterial species. Other plastisphere inhabiting plastic degrading microbes include Streptomyces, Bacillus, Achromobacter, Azospirillum, Bacillus, Brevundimonas, Clostridium, Paenibacillus, Rhodococcus, Serratia, Staphylococcus, Thermobifida, and Thermomonospora. However, the plastisphere microbiome showed potential for producing secondary metabolites that were found to act as anticancer, antitumor, anti-inflammatory, antimicrobial, and enzyme stabilizers under harsh environments. These results revealed that the plastisphere microbiome upholds clinical and environmental significance as it can open future portals in a multi-directional way.
The Gender Dimension of Vulnerability in Disaster Caused by the Corona Virus (Covid-19)
Authors: Cvetković Vladimir M. , Čvorović Milica , Beriša Hatidža
Published: September 2023

The subject of the research is an examination of the way in which the disease COVID-19 affects the gender aspects of the vulnerability of citizens, with special reference to their physical, socio-economic and psychological vulnerability. For the purposes of this research, the perception of risk and the preparedness of men and women for the SARS-CoV-2 virus pandemic was examined. The results of this research were obtained by applying a quantitative survey of the citizens of the Republic of Serbia about their experiences and attitudes regarding their vulnerability due to the COVID-19 pandemic, where special attention is paid to the gender dimension. A survey of 273 adult citizens was conducted and the results showed that there is no significant connection between the gender category and the physical vulnerability of people caused by the COVID-19 pandemic. The obtained data indicate that approximately the same percentage of women and men had severe symptoms of the disease. Nevertheless, the results showed that there is a partial connection between the gender category and socio-economic vulnerability, as well as a clear connection between the gender category and the psychological vulnerability of people caused by the pandemic. In both cases, the results indicate that women are more vulnerable socio-economically and psychologically than men. As this topic is not sufficiently represented in foreign, and especially not in domestic literature, the results of this research can serve as guidelines for future investigations of the gender dimension of people in the conditions of disasters, such as the COVID-19 pandemic.
Improving Antimicrobial Treatment in Terms of Antimicrobial Stewardship and Health Costs by an Opat Service a Single Centre Prospective Cohort Study
Authors: Burch Andrea R. , Ledergerber Bruno , Ringer Martin , Padrutt Maria , Reiber Claudine , Mayer Fabienne , Zinkernagel Annelies S. , Eberhard Nadia , Kaelin Marisa B. , Hasse Barbara
Published: September 2023

Purpose: Outpatient parenteral antimicrobial therapy (OPAT) is a standard for antimicrobial therapy internationally. With this prospective cohort study, we aimed to assess the impact of an OPAT service as part of antimicrobial stewardship (ABS) and evaluate the safety and efficiency of the program while illuminating the financial benefit for the hospital.
Methods: Socio-demographic data, treatment regimen and outcomes were prospectively recorded for all patients assigned to the program of the OPAT unit of the University Hospital of Zurich between November 2018 and September 2022.
Results: In total, we recorded 303 OPAT assignments of which 260 resulted in effective OPAT episodes. The 260 OPAT episodes were further optimized towards the choice of antimicrobial substance (n=18) and length of therapy (n=6). Moreover, OPAT resulted in alteration of patient assessment and care led by ABS strategies in 247 of 260 episodes (95%). While the bed days saved per year increased consistently with time, a total of 3934 in-hospital treatment days were saved amounting to a cost saving of 9’835’000 CHF over 47 months. Adverse events were recorded in 46 cases whilst only two of these have been the reason for readmission during OPAT treatment. Clinical cure was noted in 77% (199/260) and was negatively associated with Charlson Comorbidity Index (CCI; OR per 1 unit higher 0.85 (95% CI 0.78-0.93)).
Conclusion: This study demonstrates the impact of an OPAT service in the framework of ABS as well as its benefits for the hospital whilst preserving safety and efficacy for the patient’s parenteral antimicrobial treatment.
High-density Planting and a Smaller Row Width Increased Yield and Decreased Fruit Size of Pumpkins
Authors: Heagy Kimberly , Schultheis Jonathan R. , Birdsell Travis , Knuth Melinda , Ward Jason K.
Published: September 2023

Pumpkins (Cucurbita sp.) grown in North Carolina are a nascent specialty crop that has only risen to a national production level in the past 10 years. There are only general cultural management guidelines for this region, resulting in variation in plant density and inefficient production. Production field studies of the cultivar Kratos were conducted to investigate the impact of plant density and row width on marketable yield and individual fruit size for large carving pumpkins. Plant densities of 2691, 3588, 5382, and 10,764 plants per hectare with row widths of 1.5 and 3.0 m were grown in 2020 and 2021 in North Carolina. Data regarding fruit size, fruit size variance, and yield per area were collected. Fruit size in terms of weight, length, and diameter increased as plant density decreased. There was no difference in fruit size variation between plant densities and row widths. The fruit number per hectare and fruit weight per hectare increased as plant density increased, with the highest production at 10,764 plants per hectare. For years combined, reducing the row width from 3.0 to 1.5 m increased the fruit weight and diameter, but not the length. Additionally, the 1.5-m row width produced more fruit weight per hectare than the 3.0-m row width for both years. Growers can optimize fruit weight per area and fruit number per area by using a density of 10,764 plants per hectare. Overall, using a row width distance that is more equidistant to the in-row spacing promotes higher fruit yield and larger fruit size.
Peran Buruh Migran Perempuan dalam Melestarikan Lingkungan Hidup Perspektif Ekofeminisme dan Islam
Authors: Ain Aiyuhan Nurul , Yuslih Muhammad
Published: September 2023

Salah satu masalah besar yang dihadapi oleh bangsa Indonesia ialah buruh migran. Kemiskinan dan menyempitnya lapangan pekerjaan menjadi penyebabnya, disamping juga budaya patriarki dan ketimpangan gender yang menempatkan kaum perempuan sebagai warga kelas yang kedua (subordinat). Maka oleh karena itu, dibutuhkan pendidikan yang kritis untuk mendefiniskan kembali dan menjadikan posisi perempuan dan laki-laki menjadi setara, terlebih dalam mengelola dan melestarikan lingkungan. Tulisan ini bertujuan untuk menunjukkan atau membuktikan bahwa buruh migran perempuan memiliki kontribusi yang besar dalam melestarikan lingkungan hidup dari sudut pandang ekofeminisme dan Islam. Penelitian ini termasuk dalam jenis penelitian kepustakaan (liberary research) dengan pendekatan kualitatif dimana data yang dikumpulkan berupa pendapat, informasi dan konsep-konsep serta keterangan-keterangan yang berbentuk uraian dalam mengungkapkan masalah. Data-data yang didapatkan dari penelitian ini bersumber dari berbagai buku ilmiah, jurnal, artikel, internet dan sebagainya yang membahas peran buruh migran perempuan dalam melestarikan lingkungan hidup perspektif ekofeminisme dan Islam, disamping itu juga peneliti melakukan wawancara untuk menguatkan data. Hasil penelitian ini menunjukkan bahwa perempuan sebagai buruh migran di negara-negara tertentu dan memiliki pengalaman kerja dalam menjaga kebersihan lingkungan, setidaknya setelah pulang kampung halamannya dapat diterapkan. Sementara itu dalam Islam bekerja dan melestarikan lingkungan merupakan perbuatan yang tergolong dalam amal saleh, sehingga di mata Allah SWT keduanya merupakan perbuatan yang baik dan di ridhai Allah SWT.
Tafsir Feminin: Telaah Terhadap Ayat-ayat Mawaris
Authors: Aulia Nurul , Irham M. Iqbal
Published: September 2023

Penelitian ini bertujuan untuk mendeskripsikan makna keadilan yang terdapat pada ketentuan hukum warisan dalam islam. Di mana ketentuan tersebut menjadi salah satu isu feminisme yang paling menonjol hingga menimbulkan penafsiran terbaru di kalangan cendekiawan pada zaman modern ini, yaitu bagian warisan 2:1 antara lelaki dan perempuan. Ketentuan tersebut dianggap tidak adil, mengingat dewasa ini perempuan juga banyak berperan dalam berbagai sektor pekerjaan bahkan tidak jarang seorang istri mempunyai penghasilan yang lebih besar dari suaminya. Bila dilihat secara sosial historisnya, ayat tersebut membawa semangat revolusi perubahan yang berorientasi pada terangkatnya derajat perempuan, karena sebelum adanya ayat ini perempuan tidak mendapatkan bagian warisan justru menjadi asset yang diwariskan. Maka bila ketentuan itu dipahami secara tekstual tentulah terlihat ketidak-adilan dan lebih mengenyampingkan perempuan. Padahal keadilan tidak hanya dapat dilihat dari angka maupun kuantitas, sebab sesungguhnya keadilan menurut manusia tentulah berbeda dengan keadilan di mata Allah. Untuk itu dalam memahami makna keadilan pada ketentuan ayat tersebut harus dibarengi dengan pemahaman konsep feminisme dalam islam, di mana feminsme merupakan sebuah pergerakan perempuan yang menyuarakan keadilan dan kesetaraan atas kesadaran mereka terhadap peran, fungsi, dan tanggung jawabnya dengan berkesesuaian pada kodrat yang di anugerahkan Allah SWT kepadanya.
Penggunaan Media Loose Parts untuk Meningkatkan Motorik Halus pada Anak Usia Dini di TK ‘Aisyiyah Bustanul Athfal II Kota Probolinggo
Authors: Izzatulummah Maulida , Aziz Abd. , Kiromi Ivonne Hafidlatil
Published: September 2023

Ketertarikan anak dalam pembelajaran menjadi faktor yang sangat penting yang harus guru atau orang tua perlu diperhatikan semaksimal mungkin. Jika anak tidak tertarik dengan proses pembelajaran maka akan mengakibatkan perkembangan terutama fisik motorik anak terhambat. Dengan itu, Penelitian ini bertujuan untuk menganalisis penggunaan media loose parts untuk meningkatkan fisik motorik halus pada anak usia dini. Metode yang digunakan adalah metode deskriptif dengan penelitian kualitatif. Penelitian ini dilakukan di TK ‘Aisyiyah Bustanul Athfal II. Dengan menggunakan data teknik observasi kepada anak, wawancara kepada guru dan dokumentasi. Hasil penelitian ini menunjukkan bahwa media loose parts selalu diperlukan pada saat pembelajaran berlangsung sesuai dengan tema pembelajaran pada saat itu dan ketika jam pembelajarn selesai. Hal ini di sebabkan karena menariknya dalam permainan dan di senangi banyak anak. Selain itu juga, media loose parts ini mampu memberikan kebebasan kepada anak untuk berkreativitas sesuai dengan ide yang dimilikinya dan imajinasinya dalam proses belajar.
Glass Ceiling and Personal Sense of Power: Challenges in Women’s Career Advancement
Authors: Wulandari Angelina Arum , Rembulan Cicilia Larasati
Published: September 2023

Women’s involvement in the labor market continues to increase, but this does not happen to women in career leadership positions. In fact, women’s career advancement continues to experience obstacles and individual power plays a role in their career advancement efforts. The purpose of this research is to identify the challenges of improving women’s careers, their personal sense of power, and their efforts in improving their careers. The approach used was qualitative with an instrumental case study design. An open-ended questionnaire was distributed to get participants who fit the criteria to be interviewed, namely women who have worked for more than 1 year, there is a career ladder in their workplace, and participants indicated experiencing a glass ceiling. The results of research on four participants showed that the challenges that are still often faced by working women are discrimination in the work environment, family environment expectations regarding women’s domestic roles, and internalization of feminine roles in individuals. Participants indicated to have different personal sense of power, ranging from low to high. Individuals with a high personal sense of power tend to dare to express their opinions and are able to make structured plans for career development. While individuals with a low personal sense of power tend to be more silent, but still show a desire to develop a career.
Hubungan Pola Perilaku Pengunjung dengan Karakteristik Arsitektur Istana Datu Luwu Kota Palopo
Authors: Rizaldy Mohammad , Wikantari Ria , Sir Mohammad Mochsen
Published: September 2023

Title: The Relationship between Visitor Behavior Patterns and the Architectural Characteristics of Datu Luwu Palace, Palopo City
 
The research aims to find the relationship between visitor behavior patterns and the architectural characteristics of the Datu Luwu Palace in Palopo City. Datu Luwu Palace has important historical and cultural significance as a historical building complex in South Sulawesi. Factors such as the layout, visual design, and architectural elements within the palace can influence visitor behavior patterns. The research used a qualitative approach with a survey of visitors. Data were analyzed using spatial techniques to identify visitor behavior patterns and their relationship to the architectural characteristics of the palace. The results show a significant relationship between visitor behavior patterns, visit time, activities, and space preferences with the architectural characteristics of the Datu Luwu Palace. Architectural characteristics, such as traditional ornamentation, room layout, and materials, play an important role in shaping visitors' experiences and their activities within the palace. Research provides new insights into the management and development of historic tourist destinations. By better understanding the influence of architectural characteristics on visitor behavior patterns, tourism authorities and managers can take more effective steps to maintain, preserve, and enhance the visitor experience. The results of the research can be the basis for better planning in maintaining historical and cultural values, and on the other hand, fulfilling visitors' expectations in exploring tourist destinations. Research has a positive impact on the development and promotion of South Sulawesi's cultural heritage.
ASSESSMENT OF DIETARY KNOWLEDGE, ATTITUDE, AND PRACTICES AMONG PATIENTS ON HAEMODIALYSIS INA TERTIARY CARE CENTRE
Authors:   Professor, Department of Community Medicine and Public Health, King Georges Medical University. UP, Lucknow, India., Kumari Reema , Kumar Sawlani Kamal ,   Professor, Department of Medicine, King Georges Medical University. UP, Lucknow, India., Chaturvedi Ritika ,   Junior Resident, Department of Community Medicine and Public Health, King Georges Medical University. UP, Lucknow, India., Kumar Singh Ajit ,   Junior Resident, Department of Community Medicine and Public Health, King Georges Medical University. UP, Lucknow, India.
Published: September 2023

Background:Dietary modifications are recommended in patients undergoing haemodialysis to prevent complications. This study assessed the patients knowledge, attitude and practices regarding the diet that needs to be followed by patients. Methods: Cross-sectional study was conducted among 106 patients on haemodialysis admitted at Tertiary Care Centre from September to December 2022. A semi-structured questionnaire was used. Data analysis was done using SPSS by applying descriptive statistics and Chi-square test. Results: Study showed 88% of patients had good knowledge regarding renal diet.Significant association was found between knowledge and attitude regarding reducing potassium in their diet (p<0.028).90.5% of patients reduced salt intake by adding less salt in diet.72.6% of patients were counselled by doctors regarding diet chart. Conclusion:Results of this study showed the importance of regular counselling by qualified doctors or dieticians which needs to be undertaken to include culturally and individually acceptable alternatives to food.
MARKETING STRATEGY BY MISSION SHAKTI OF ODISHA: A JOURNEY FROM SELF HELP GROUPS (SHGS) TO SMALL AND MEDIUM-ENTERPRISES (SMES)
Authors:   Ph.D. Research Scholar, Sambalpur University Research Fellow (SURF)., Chandra Dash Kailash , Kanti Das Tushar ,   Professor & Head.
Published: September 2023

Empowerment of women playing a significant role in society. When women will empower with financially at that time her family income level increase. Mission Shakti gives the power to increase his financial stability. In layman language we can say the women is Samarthy to run her family. Indian constitution provides the women equal freedom and opportunity, so they can empower by them self. Both literate and illiterate women have rights to empower by themselves. So Government of Odisha plays a significant role to empower women through Mission Shakti Department. This department has deep reach to women, nearly about 70 lakh women through 6 lakh groups. The groups are self empower by them self selves through the help of the Mission Shakti.This Paper is mainly focused how the group is converted SHGs to SMEs with the help of Mission Shakti. What types of Marketing Strategy they followed to reach her goal from SHGs to SMEs.Marketing tactics used by cluster members to sell the manufactured goods, as well as the intensity of empowerment among members of women, SHGs to SMEs in Sustainable Livelihood actions. Data were obtained from the districts of Angul and Khordha using a standardized questionnaire written in the local language. Around 180 members of various women SHGs were chosen for the study. The SPSS software was used to analyze the data. The data was analyzed using one-way Anova, multiple regression, and Pearson correlation. most crucial components such as Sustainable Livelihood, Women Entrepreneurship, and Women Empowerment, all of which have a significant impact on the performance of Marketing Strategies used by SHG members in rural Odisha. It was also bring into being that the number of SHG members and the time-span of years the SHG group has been founded had a substantial impact convert SHGs to SMEs.
LA FORMATION DU RESIDENT EN CHIRURGIE PLASTIQUE AU MAROC QUEN EST-IL ?
Authors: Elatiqi Oumkeltoum , Driss Elamrani Moulay , Benchamkha Yassine
Published: September 2023

La formation en chirurgie plastique doit repondre a la pratique clinique et doit suivre le progres de la societe, cela fait plus que 20 ans que le premier chirurgien plastique a ete diplÃ´me au Maroc, notre etude vise a faire un bilan sur la formation en chirurgie plastique a travers lelaboration dun questionnaire qui a ete envoye a lensemble des chirurgiens plastiques formes et diplÃ´mes au Maroc et aux residents qui sont toujours en formation ,cela nous a permis la collecte des avantages et des defauts de cette formation. Nous avons essaye a partir de ces resultats de proposer des solutions, du fait que 69% ne sont pas satisfaits. Parmi les problemes rencontres on trouve que la brulure inonde la formation dans 96% des cas , cependant lapprentissage du contingent esthetique est estime a 26%, alors quil sagit de la principale demande chez les patients une fois diplÃ´mee, de ce fait la chirurgie plastique au Maroc merite une restructuration de son apprentissage et de son exercice . Abstract : Training in plastic surgery should respond to clinical practice and should keep pace with the progress of society, its been 20 years since the first plastic surgeon graduated in Morocco, our study aims to take stock of training in plastic surgery through the development of a questionnaire that was sent to all plastic surgeons trained and graduated in Morocco and to residents who are still in training, this allowed us to collect the advantages and shortcomings of this training. We tried from these results to propose solutions, in fact 69% are not satisfied, among the problems encountered, the burn floods the formation in 96%, however, the learning of the aesthetic contingent is estimated at 26%, while this is the main demand among patients after graduation, therefore plastic surgery in Morocco deserves a restructuring of its learning and practice.
EVALUATION OF PUBLIC AWARENESS, KNOWLEDGE, AND ATTITUDES ABOUT COLORECTAL CANCER SCREENING AMONG THE GENERAL POPULATION IN AL-QUNFUDAH, SAUDI ARABIA
Authors:   AlQunfudah College of Medicine, Umm Al-Qura University, Alqunfudah, Saudi Arabia., Aldabali Fatimah , Alkhaldi Ali ,   AlQunfudah College of Medicine, Umm Al-Qura University, Alqunfudah, Saudi Arabia., Alrashdi Afnan ,   AlQunfudah College of Medicine, Umm Al-Qura University, Alqunfudah, Saudi Arabia., Alqarni Ghaday ,   AlQunfudah College of Medicine, Umm Al-Qura University, Alqunfudah, Saudi Arabia., Alnashri Fatimah ,   AlQunfudah College of Medicine, Umm Al-Qura University, Alqunfudah, Saudi Arabia., Alotibi Batool ,   College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Alsllami Abdullah ,   South Al-Qunfudah General Hospital, Department of General Surgery, AlQunfudah, Saudi Arabia., Alshareef Basem ,   Department of Surgery, Umm Al-Qura University, Makkah, Saudi Arabia.
Published: September 2023

Colorectal cancer (CRC) is a malignant tumor of the colon and rectum. It can be cured if detected in the early stage through established screening programs. CRC screening is the best way to improve cancer morbidity and mortality. Various approaches such as stool tests, virtual colonoscopy, and sigmoidoscopy are available for early de- tection. On average, a person after reaching the age of 45 should begin the screening process for CRC periodically for 5 years. Our study aims to measure the populations awareness and knowledge of the effect of CRC screening on CRC outcomes. A cross-sectional study questionnaire was designed and distributed among Saudi residents of the Al-Qunfudah region. A total of 385 participants replied: 55.8% of the participants were males, 78.8% of the study participants mentioned that they had heard about CRC, and 27.3% reported that CRC is common in Al-Qunfudah. In addition, 62.1% knew that CRC is more common in men but only 32.2% had a good awareness level. Moreover, 16.4% of the participants reported that they had received a colonoscopy/sigmoidoscopy 69.9% did not think of the colonoscopy/sigmoidoscopy procedure as the main barrier to undergoing early screening for CRC. Good aware- ness regarding CRC was demonstrated in 34.4% of highly educated participants, which was directly associated with levels of education. In conclusion, much more awareness regarding CRC screening is needed in the Al-Qunfudah region. Educational seminars and programs should be made mandatory, and the healthcare system should focus on high-risk individuals.
METHOD DEVELOPMENT AND VALIDATION OF TIVOZANIB BY RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Authors:   Associate Professor, Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad., Raja Reddy A. , Sushma G. ,   M. Pharm PG Student, Department of Pharmaceutical Analysis, CMR College of Pharmacy, Hyderabad., Rama Rao T. ,   Professor and Principal CMR College of Pharmacy, Hyderabad., Kalyan Varma V. ,   Associate Professor, Department of Pharmaceutical Analysis, Shree Dattha Institute of Pharmacy Hyderabad., Neelaveni K. ,   Associate Professor, Department of Pharmaceutical Chemistry, CMR College of Pharmacy, Hyderabad.
Published: September 2023

The estimation of Tivozanib by RP-HPLC methodology was established using a simple, concise, and accurate method. Use of stationary Discovery C18 150mm x 4.6 mm, 5.mm, mobile phase 0.1% chromatographic conditions Orthophosphoric acid was mixed with acetonitrile in a 50:50 ratio, with a flow rate of 1.0 ml/min, a detection wavelength of 320 nm, a column temperature of 30 Oc, and mobile phase as the diluent. A retention time of 2.702 minutes was discovered. The standard was injected six times to study system suitability parameters, and the findings fell far short of the threshold for acceptance. An analysis of linearity between levels of 25% and 150% revealed an R2 value of 0.999. Precision for the Method was found to be 0.8, 0.6, and 0.9 for medium level of accuracy. 0.05 g/ml and 0.16 g/ml, respectively, are the LOD and LOQ. The assay of a commercial formulation was conducted using the procedure and 100.10% was found. Studies on the degradation of tivozanib were conducted, and under every circumstance, the purity threshold was higher than the purity angle and within the acceptable range. Even though the complete approach has not been tested yet, it can be used in order to do further analysis of Tivozanib routinely.
Change in the quality of life in different countries of the world: Assessment on the EQLS database
Authors: Živčicová Eva , Masárová Tatiana , Gullerová Monika
Published: September 2023

The European Quality of Life Survey (EQLS) is a tool that assesses quality of life across different aspects. Monitoring the quality-of-life indicators in times of crisis and post-crisis is crucial for human resource management as the quality-of-life indicators provide valuable insights into the well-being and needs of employees. The study aimed to examine the impact of social and economic changes on the selected quality of life areas of the EU population by analyzing data from the ESQL of 2016 and 2020. It was found that the average EU life satisfaction score went down. In 2020, the EU optimism average dropped when compared to 2016. According to 2020 survey data, EU citizens found coping with life’s challenges harder than in 2016. The EU average regarding the difficulty of dealing with essential issues in life increased by 1.5% in 2020 compared to 2016. The time needed to get back to normality after some mishaps was also investigated. The EU average regarding subjective feelings of tension rose by 7.4%. In comparison to 2016, depression and downheartedness grew stronger across the EU nations and the EU average in 2020. The average value increased by 6.8%. The changes may provide insights into the effects of social and economic trends on people’s well-being across Europe.
AcknowledgmentThe paper is written under the project Multiplier effects of human capital quality on economic performance and competitiveness of the Slovak economy and supported by the Grant Agency VEGA of the Ministry of Education, Science, Research and Sport of the Slovak Republic [No. 1/0357/21].