bluuebunny/crossref_metadata_2025 huggingface dataset:
The reabilitation after replacement of achilles tendon
Authors: Sergeev S V , Minasov B Sh , Kolovertnov D E , Karpovich N I
Published: December 2019

This study reveals the new method - endoprosthetic Achilles tendon. As a result of the study the optimal implant was created, operational surgery of Achilles tendon endoprosthetics was modified and the recover program was formed. Current method allows to avoid immobilization of the operated limb but to carry out early rehabilitation activities and exercises with intent to restore triceps muscular strength. The remote results in 6 month's after Achilles tendon replacement in 34 patients were excellent, in 46 patients were good and in 1 patient were unsatisfactory.
Problem issues of medical-social rehabilitation of elderly and senior persons at the modern stage
Authors: Puzin S N , Memetov S S , Sharkunov N P , Kim V V , Litvinova Yu V
Published: December 2019

The article analyzes the needs of the elderly and senile in medical and social assistance and rehabilitation. Some problems in solving medical and social problems of the studied category of persons are reflected. Measures are proposed to eliminate the causes that reduce the quality of life of the studied contingent. Attention is drawn to the need to simplify the examination procedure at the ITU bureau for elderly and senile people, both with a view to establishing a disability group, and for compiling an IPRA, including providing disabled people with technical rehabilitation equipment.
Correction of cerebral thermal balance disruption in therapy and rehabilitation of patients with cerebral pathology
Authors: Shevelev O A , Petrova M V , Saidov Sh Kh , Chubarova M A , Usmanov E Sh , Pranil Pradkhan -
Published: December 2019

Temperature monitoring of the brain using radiothermometric technology allows you to assess the imbalance of the thermal balance of the brain, and the technique has shown the possibility and information content of its use in the diagnosis of cerebral lesions. In healthy individuals, at rest, the average temperature of the left (36.74 ± 0.37 ° C) and the right hemisphere (36.64 ± 0.32 ° C). In boxing athletes who received "planned" minor traumatic brain injuries after training sparring, the average temperature of the left (38.4 ± 0.28 ° C) and right temperature (38.2 ± 0.45 ° C), which is significantly elevated. Patients in chronic critical conditions showed a monotonous temperature distribution in the left (36.98 ± 0.18 ° C) and right hemispheres (36.88 ± 0.21 ° C). The temperature heterogeneity of the brain in this category of patients was less pronounced compared with healthy individuals, athletes after sports head injury.
Place of neurourology in the clinical neurology system. Neurourological rehabilitation
Authors: Kadykov A S , Shvedkov V V , Korshunova E S , Pryanikov I V
Published: December 2019

Disorders of urination of an obstructive and irritative nature are found in almost all major diseases of the nervous system and their symptoms are largely reminiscent of dysuric disorders in the local pathology of the urethra and bladder. Proper diagnosis and timely treatment determine not only the quality of life, but sometimes the very life of patients. Only the combined efforts of neurologists and urologists in the framework of the clinical direction "Neurouroscience" allows us to timely diagnose the cause of urination disorders and carry out the necessary treatment and rehabilitation measures.
Is there any association between antibiotic resistance and virulence genes in Enterococcus isolates?
Authors: Aşgın Nergis , Taşkın Emre
Published: December 2019

Objective: In this study, we aim to determine the frequency of antibiotic resistance and five virulence genes in Enterococcus species and the relationship between antibiotic resistance and virulence genes.

Material and Methods: A total of 86 Enterococcus strains isolated from inpatients between 2015 and 2016 were included. Identification and antibiotic susceptibilities of strains were determined using a BD Phoenix fully automated system. The presence of virulence-associated genes (esp, gel E, asa1, hyl, and cyl) were investigated by using PCR method.

Results: Of the 86 Enterococcus strains, 53 (61.6%) and 33 (38.4%) were Enterococcus faecium and Enterococcus faecalis, respectively. Vancomycin and high-level gentamicin resistance (HLGR) in E. faecalis strains were 0.6% and 60.6%, respectively. Furthermore, 52 of the 53 E. faecium strains were both vancomycin-resistant and HLGR. The frequency of esp, gel E, asa1, cyl, and hyl was 91.9%, 60.5%, 54.7%, 43%, and 26.7%, respectively.  The asa 1, cyl, and gel E genes were detected at high frequencies in vancomycin-susceptible and non-HLGR strains, whereas hyl gene was detected at high frequencies in vancomycin-resistant and HLGR strains.

Conclusion: Virulence genes were more frequent in vancomycin-susceptible and non-HLGR Enterococcus strains than in the resistant strains. Although infections caused by multidrug-resistant strains are difficult to treat, it should be considered that susceptible strains have more virulence genes. This may reduce the in vivo efficacy of drugs and lead to treatment failures. Therefore, in addition to the in vitro susceptibilities of drugs, clinical efficacy should be monitored.
The Evaluation of Upper Airway: Point of Care Ultrasound vs. Conventional Tests
Authors: Yıldız Burak , Çevik Banu , Karaduman Yılmaz , Sezen Özlem , Saraçoğlu Kemal Tolga
Published: December 2019

Objective: The ultrasound-guided interventions have gained widespread popularity in several aspects of anesthesia practice. In this study, we aimed to compare the preoperative evaluation tests and sonographic measurements of the upper airway for the prediction of a potentially difficult airway.

Material and Methods: In this prospective observational study, we enrolled 136 adult patients undergoing elective surgery under general anesthesia. The Modified Mallampati classification, thyromental distance, sternomental distance, and Cormack-Lehane scores were recorded. Sonographic measurements included pre-epiglottic space (PES), the distance between the midpoints of vocal cords and epiglottis (EVC). The ratio was interpreted. Main outcome is to determine the sensitivity and specificity of the upper airway ultrasound for the prediction of a potentially difficult airway.

Results: There was no statistically significant relationship between body mass index value and thyromental distance, Thyromental/Sternomental Ratio and PES/EVC ratio, Cormack-Lehane, Mallampati classification and thyromental/sternomental distance ratio (p>0.05). The sonographic measurements of airway have no significance to predict the difficult intubation and the comparison between PES, EVC and the PES/EVC ratio and assessment tests (Cormack-Lehane, Mallampati classification, thyromental and sternomental distances) was insignificant. The sternomental distance measurement was predictive for the difficult airway only in patients having body mass index more than 31.6 kg m-2.

Conclusion: Ultrasound is a useful tool for identifying the upper airway prior to anesthesia but the validity for the prediction of difficult airway is not clear. By increasing the clinical experiences and further investigations, a greater insight into its use will be gained.
Filosofia brasileira como busca por identidade cultural na obra de Henrique de Lima Vaz
Authors: Tauchen Jair Inácio , Musella Pedro Brosina
Published: December 2019

Henrique de Lima Vaz foi um dos pensadores brasileiros responsável por diversas conquistas no contexto de expansão da educação no país. Sua análise interpretativa da filosofia decorre do diagnóstico social, cultural e histórico não apenas do Brasil, mas de toda filosofia ocidental. O objetivo do texto é analisar o conceito de identidade cultural brasileira, através dos textos de Lima Vaz, buscando elementos na história da filosofia brasileira as raízes do pensamento no Brasil contemporâneo. O problema consiste em identificar subsídios no contexto histórico e social, que fazem com que a filosofia brasileira seja diferente das demais filosofias ocidentais e como ela se relaciona e se desenvolve na busca por uma identidade cultural brasileira. É possível deduzir que processo de identidade cultural brasileira ainda sofre influência externa e se encontra em formação.
??? -????? Religioso: Religião Como alternativa ao mal-estar na Civilização
Authors: Miranda Claudio
Published: December 2019

O presente artigo busca refletir sobre o mal-estar na civilização, conforme exposto por Freud em “O Mal-estar na Civilização”, e do ponto de vista da teologia cristã. Assumindo a religião como uma alternativa à sublimação desse mal-estar, e no contexto do diálogo inter-religioso, interroga se as diferentes tradições podem representar uma alternativa igualmente válida, perguntando ainda sobre critérios mínimos para que uma religião possa ser considerada verdadeira e boa.
A defesa hobbesiana do autoritarismo
Authors: Filho Mauricio Fontana
Published: December 2019

A defesa hobbesiana do autoritarismo
APPLICATION SINERGETIKO-INSTITUTSIONALNOGO OF THE APPROACH FOR OVERCOMING OF DISPROPORTIONS IN DEVELOPMENT OF TERRITORIES
Authors: Goloktionova Ju.G. , Lisichkina N.V.
Published: December 2019

Stratification of economic space strengthens the natural disbalance manifested in the devel-opment of separate regions of the country. Evening-out of territorial disproportionality is one of the priority directions of state regulation of social and economic sphere both at the regional, and at federal levels. Synergetic-institutional approach to management of spacial development is one of the tools, allowing to stabilize macroeconomic situation.
TECHNICAL APPROACH TO FORMATION OF INSTITUTINAL DEVELOPMENT TOOLS OF AGRARIAN REGIONS OF THE COUNTRY AS THE BASES TO OVERCOME DISPROPORTIONS
Authors: Ilminskaya S.A. , Ilukhina I.B.
Published: December 2019

Factors of “the first nature” predetermined agrarian direction of Orel region. The supply of land is an important resource of strategic development of the region. The expediency of differentiated approach to the formation of the rent rate for the use of the land in Orel region, and the plots state ownership of which is not differentiated is substantiated taking into account the level of busi-ness activity of each municipal union.
CALCULATION OF TREATMENT OF LOOSE BULKY MATERIALS WITH OZONE-CONTAINING GAS
Authors: Simonov Аleksandr Alekseevich , Parpiev Mukhammadjon Parpievich , Kamardin Аleksey Ivanovich , Khaydarov Bakhtiyor Abdulkhamidovich
Published: December 2019

Particularity of treatment of loose bulky materials with gas was analyzed, calculated loss of pressure under their gas treatment. It was ascertained that porosity (pore) of such objects as a layer for seeds of farming crops constitutes approximately 0,4 by capacity. Recommendations were presented on the construction of equipment’s and peculiarity of treatment of layers for seeds and fruit-vegetable products with ozone.

KEYWORDS: fruit-vegetable products, ozone-containing gas, loose bulky materials, porosity.
PENINGKATAN PEMAHAMAN KONSEP SIFAT-SIFAT BANGUN RUANG SEDERHANA MELALUI MEDIA KOTAK/KUBUS PADA SISWA KELAS IV SDN NGAMPELREJO KECAMATAN JOMBANG KABUPATEN JEMBER SEMESTER GENAP TAHUN 2018/2019
Authors: PAMBUDI AGUS
Published: December 2019

Peningkatan pemahaman konsep sifat-sifat bangun ruang sederhana kotak / kubus pada siswa kelas IV SDN Ngampelrejo 02 Kab.Jember. Sebagai seorang guu yang ingin meningkatkan pemahaman konsep pada muridnya berusaha semaksimal mungkin dengan berbagai cara yang baik sudah dilakukan,pengaruh lingkungan dan lingkungan sekolah juga ikut mendukung dalam mensukseskan usaha guru
MASIHKAH PELATIHAN DAN PENGEMBANGAN SDM MEMPENGARUHI KINERJA STUDI PADA TARUNA SIAGA BENCANA (TAGANA) KABUPATEN SUBANG
Authors: Silvia Iyang Cucu , Firmansyah Yayan
Published: December 2019

This study aims to determine: (1) the effect of training on performance of Taruna Siaga Bencana (Tagana), (2) the effect of human resources development on performance of Taruna Siaga Bencana (Tagana), (3) and the effect of Training and Development of Human Resources on Performance of Taruna Siaga Bencana (Tagana). The method used in this study was descriptive and verification. The data were collected by questionnaire and interview techniques. Respondents in this study amounted to 78 people who were members of Taruna Siaga Bencana (Tagana). The results of this study indicate that: (1) Training has a positive and significant effect on the performance of Tagana (9.63%). (2) Development of human resources has a positive and significant effect on the performance of Tagana (20.5%). (3) Training and development Human resources have a positive and significant effect on performance of Taruna Siaga Bencana (Tagana) with a coefficient of 47.7%, while the remaining 52.3% is influenced by other variables which are not examined in this study. Job training and Development Human resources are very beneficial for Taruna Siaga Bencana (Tagana) Kab. Subang to make them be ready in the task of disaster management stages. Therefore, training and development programs for human resources need to be improved and carried out sustainably and has a clear implementation
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN NASABAH PADA PT. BPRS BERKAH DANA FADHILILAH AIR TIRIS KAMPAR
Authors: Mustika Aai
Published: December 2019

The Effect of service quality on customer satisfaction at PT. BPRS Berkah Dana Fadhililah Air Tiris Kampar. The purpose of this study was to determine the effect of service quality on customer satisfaction at PT. BPRS Berkah Dana Fadhililah Air Tiris Kampar. The sample in this study were 99 people taken randomly. The survey results in the field obtained the level of customer service quality seen from the five dimensions of assessment (Tangible - Physical appearance, Responsiveness - Speed, Assurance - guarantee, Reliability - Performance, Empathy - care) at PT. BPRS Berkah Dana Fadhililah Air Tiris Kampar, from the results of the analysis of the five dimensions, the Empathy dimension (Service to customers does not distinguish social status) is the most dominant according to the responses of respondents with an average of 4.64. Regression equation obtained by Y = 24.298 + 0.541X, testing the hypothesis with t_count 6.518 (greater than t table ie 1.984) and P-Value <0.05 (0.00 <0.05) then Ho is rejected, while the coefficient of determination is 30.5%, meaning 30.5% satisfaction customers affected by the remaining service quality 69.5% are influenced by other factors.
KETERSEDIAAN SARANA PRASARANA, KOMPETENSI KERJA DAN IKLIM ORGANISASI DALAM MEMPENGARUHI KINERJA PERAWAT DI RUMAH SAKIT JIWA (RSJ) PUTI BUNGSU PADANG
Authors: Yulihardi Yulihardi , Akmal Akmal
Published: December 2019

Masalah yang diangkat dalam penelitian ini adalah “Kinerja Perawat  Di Rumah Sakit Jiwa  (RSJ) Puti Bungsu Padang Adapun variabel penelitian ini adalah pengaruh Sarana Prasarana, Kompetensi Kerja dan Iklim Organisasi (sebagai variabel bebas) dan  Kinerja Perawat (sebagai variabel terikat).  Penelitian ini memperhatikan tingkat Kinerja Perawat  dan juga perlu diperhatikan Sarana Prasarana, Kompetensi Kerja dan Iklim Organisasi tersebut. Dengan mengupayakan  meningkatkan Kinerja Perawat dalam rangka pencapaian  tujuan  Rumah Sakit, khususnya Di Rumah Sakit Jiwa  (RSJ) Puti Bungsu Padang. Penelitian ini bertujuan untuk mengungkapkan, Pengaruh Sarana Prasarana, Kompetensi Kerja, dan Iklim Organisasi secara bersama-sama terhadap  Kinerja Perawat  Di Rumah Sakit Jiwa  (RSJ) Puti Bungsu Padang. Pengaruh Sarana Prasarana, Kompetensi Kerja, dan Iklim Organisasi secara parsial terhadap  Kinerja Perawat  Di Rumah Sakit Jiwa  (RSJ) Puti Bungsu Padang. Kesimpulan dari penelitian bahwa Hipotesis secara parsial dan simultan dari  variabel  Sarana Prasarana, Kompetensi Kerja dan Iklim Organisasi terbukti memiliki pengaruh positif dan signifikan terhadap Kinerja Perawat  Di Rumah Sakit Jiwa  (RSJ) Puti Bungsu Padang dengan kontribusi 60,9% dengan Sarana dan prasarana sebagai variabel yang paling dominan. Saran Agar lebih fokus untuk memperbaiki variabel Iklim Organisasi dengan memperhatikan indikator-indikatornya
FAKTOR - FAKTOR YANG MEMPENGARUHI PRILAKU KONSUMEN DALAM KEPUTUSAN PEMBELIAN DI PERCETAKAN ADHYA MULTI SUKSES
Authors: Munthe Richa Afriana
Published: December 2019

The development of business and technology in the current era of globalization is growing rapidly and is characterized by a level of competition between companies that is getting higher and tougher. With current technological developments have changed the pattern of human work to be increasingly fast, effective and efficient in doing a job, especially in data processing. So there needs to be an adjustment between work patterns with technological developments. The purpose of this study was to determine the factors that influence consumer behavior in purchasing decisions at Adhya Multi Sukses printing. The population in this subject are consumers who have made purchases at the Adhya Multi Sukses Printing in 2017. The sampling technique in this study is to use simple random sampling, which is a method of sampling non probalities by simple random methods and each respondent has the same possibility of being selected as a respondent. To determine the number of samples using the Slovin formula, 95 samples were obtained from a population of 1,845 people. The results showed that the product, price, promotion, and distribution channels affected the purchasing decisions at Adhya Multi Sukses printing
DESCRIPTION OF THE EFFORTS OF PARENTS WITH DOWN SYNDROME CHILDREN ON DEVELOPMENT OF FIRST LANGUAGE ACQUISITION
Authors: Khalida Rahmi
Published: December 2019

Down's syndrome is one type of child with special needs. The existence will affect the quality of family life by influencing what happens to them. This study aims to describe the efforts of parents on the development of the first language acquisition of children with Down syndrome. The method used in this study is a qualitative method using descriptive qualitative. Research data were collected through interviews and observations. The subject of this study supports two families who have Down syndrome children. Data processed by content analysis. From the results of the study showed that the requirements for the ability to obtain child assistance from the stimulus from the beginning that represents acceptance in children by the microsystem environment that is family.
ASPECTS OF SELF-ESTEEM IN THE TOURISM DEVELOPMENT IN KARO REGENCY, NORTH SUMATERA, INDONESIA
Authors: GINTING Nurlisa , RAHMAN Vinky , NASUTION Achmad
Published: December 2019

Due to its positive effects on the economy, tourism is a significant aspect in the development of a country. Therefore, it is necessary to improve facilities at tourism destinations as well as to especially increase the local people’s self-esteem in order to maintain such destinations. The study aims to examine self-esteem referring to the assessments given by tourists and residents in which such assessments can be used to improve the maintenance of tourist attractions in a region. As one of the regencies in North Sumatera Province, Karo owns great tourism potentials due to its various natural attractions as well as cultural richness. However, many of these attractions are not well maintained so self-esteem is considered as a solution. This study has measured four aspects namely evaluation, pride, attachment, and commitment which must become parts of Karo’s identity. This study used the mix method which utilized a combination of 360 questionnaires and in-depth interviews. The findings show that the aspects of pride, attachment, and commitment became the positive features by the local residents although the assessment to the aspect is poorly evaluated. Moreover, the quality of infrastructures available at main tourism destinations was proved to increase also the residents’ quality of life.
NONPARAMETRIC CORRELOGRAM TO IDENTIFY THE GEOGRAPHIC DISTANCE OF SPATIAL DEPENDENCE ON LAND PRICES
Authors: WEKU Winsy , PRAMOEDYO Henny , WIDODO Agus , FITRIANI Rahma
Published: December 2019

The spatial autocorrelation measurement of land prices uses a covariance function to describe the spatial dependence and it can be identified as a geographic distance on the correlogram. The geographic distance of spatial dependence can state that land prices are interdependent to each other and scattered in the research area. Therefore, the purpose of this research is to define the geographic distance of spatial dependence on land prices using a nonparametric correlogram. A nonparametric approach to covariance functions using the composition of Bessel and Gaussian-type functions are adopted because they correspond to the positive definite characteristics. The cubic spline interpolation is used to refine the curve fitting, while the intersection between the nonparametric correlogram value C(h) against the horizontal axis is determined using the Jenkins Traub algorithm. The results showed that the nonparametric correlogram identified a geographic distance of land prices smaller than the correlogram used so far. A small distance means that the land price in a location is greatly affected by the neighbors compared to a larger distance.
Shear Measurement Bias Due to Spatially Varying Spectral Energy Distributions in Galaxies
Authors: Kamath Sowmya , Meyers Joshua E. , Burchat Patricia R. ,   (LSST Dark Energy Science Collaboration)
Published: December 2019

Galaxy color gradients (CGs)—i.e., spectral energy distributions that vary across the galaxy profile—will impact galaxy shape measurements when the modeled point-spread function (PSF) corresponds to that for a galaxy with spatially uniform color. This paper describes the techniques and results of a study of the expected impact of galaxy CGs on weak lensing measurements with the Large Synoptic Survey Telescope (LSST) when the PSF size depends on wavelength. The bias on cosmic shear measurements from CGs is computed both for parametric bulge+disk galaxy simulations and for more realistic chromatic galaxy surface brightness profiles based on Hubble Space Telescope V- and I-band images in the All-Wavelength Extended Groth Strip International Survey (AEGIS). For the parametric galaxies, and for the more realistic galaxies derived from AEGIS galaxies with a sufficient signal-to-noise ratio that CG bias can be isolated, the predicted multiplicative shear biases due to CGs are found to be at least a factor of two below the LSST full-depth requirement on the total systematic uncertainty in the redshift-dependent shear calibration. The analysis code and data products are publicly available (https://github.com/sowmyakth/measure_cg_bias).
Oral Microbial Flora in Bulgarian Adolescents with Moderate Plaque-induced Gingivitis
Authors: Peycheva Stela K. , Apostolova Elisaveta G. , Peychev Zhivko L. , Gardjeva Petya A. , Shishmanova-Doseva Mihaela S. , Murdjeva Marianna A.
Published: December 2019

Introduction: In children and adolescents, the most common periodontal disease is the plaque-induced gingivitis.Aim: The aim of this study was to reveal the bacterial species associated with supragingival plaque of Bulgarian adolescents diagnosed with plaque-induced gingivitis.Materials and methods: Supragingival plaque samples from 70 healthy subjects with moderate plaque-induced gingivitis (37 females and 33 males), aged 12-18 years, were obtained and examined microbiologically.Results: A total of 224 microorganisms were isolated. Gram-negative bacteria were predominant compared to Gram-positive [132 (59%) vs. 92 (41%), p<0.001]. Aerobic microorganisms were detected more often than anaerobic (151; 67.5% vs. 73; 32.5%, p<0.001). The Streptococcus mutans group and Neisseria spp. were isolated from all adolescents. The frequency of isolation of C. albicans was relatively lower – 11 (15.7%). The anaerobes showed much greater microbial diversity (12 pathogen groups were isolated). Gram-negative rods were isolated from 57 of the adolescents (isolation frequency 81.4%). F. varium, P. melaninogenica, P. intermedia and P. assacharolyticus were detected respectively in 12 (16%), 9 (12%), 8 (11%) and 7 (10%) samples. The less frequently isolated anaerobes were Gram-positive cocci, Gram-negative cocci, Bacteroides uniformis and Bifidobacterium spp. together.Conclusion: The most frequently isolated microbiota in our study is part of the normal oral bacterial flora. The presence of anaerobes such as Prevotella, Fusobacterium, Bacteroides and Porphyromonas reflects the gradual change of the flora to more complex one. The results of quantitative and qualitative evaluation of the plaque of adolescents with moderate plaque-induced gingivitis may contribute to the selection of the prevention and treatment of this disease.
Treatment Optimization of Post-pneumonectomy Pleural Empyema
Authors: Petrov Danail B. , Subotic Dragan , Yankov Georgi S. , Valev Dinko G. , Mekov Evgeni V.
Published: December 2019

Introduction: Pleural empyema after pneumonectomy still poses a serious postoperative complication. A bronchopleural fistula is often detected. Despite various therapeutic options developed during the last five decades it remains a major surgical challenge. Results: There is no widely accepted treatment for post-pneumonectomy pleural empyema (PPE) and the management depends mostly on the presence or absence of broncho-pleural fistula (BPF) and the patient’s general condition. In the absence of BPF, the role of surgery is still not clear because of its high morbidity and impossibility to prevent recurrences. In the earlier period, the definitive treatment consisted of open window thoracostomy followed by obliteration of the pleural cavity with antibiotic solution at the time of chest wall closure. Subsequently, the proposed different methods and modifications improved the outcome. There is an association between hospital volume and operative mortality after the lung resection. Hospital volume and the surgeon’s specialty have more influence on the outcome than the individual surgeon’s volume.Conclusions: Treatment management of PPE should be individualized. Definitive treatment options comprise aggressive surgery that is not possible in quite a high proportion of impaired patients. Hospital volume, surgeon’s volume and surgeon’s specialty may influence the prognosis.
Pulmonary Kaposi's Sarcoma - Initial Presentation of HIV Infection 
Authors: Komitova Radka , Chudomirova Krasimira , Abadjieva Tsvetana
Published: December 2019

Kaposi’s sarcoma is the most common malignancy associated with human immunodeficiency virus. It commonly affects the skin but can present with visceral involvement, including the lungs. A 23-year-old homosexual male presented with fever, intractable cough and dyspnea. On examination, multiple skin lesions were revealed. Chest computed tomography visualized multiple nodules, bronchoscopy showed endobronchial lesions. Histopathological study of the skin lesions showed Kaposi’s sarcoma and the endobronchial biopsy – a proliferative inflammatory process. Diagnosis of Kaposi’s sarcoma was made based on clinical, laboratory, computed tomography and bronchoscopy data as well as on the regression of pulmonary nodules by the combination antiretroviral therapy. The diagnosis of pulmonary Kaposi’s sarcoma is still a challenge due to concomitant occurrence of opportunistic infections. This case emphasizes the need to strongly consider pulmonary KS as a possible cause for respiratory illness in any HIV-positive patient with cutaneous Kaposi’s sarcoma. 
Endothelin-1 Level in Patients with Simple Renal Cyst
Authors: Çalişkan Selahattin , Sungur Mustafa , Eser Bariş , Kanbay Mustafa , Kocan Hüseyin , Topaktas Ramazan
Published: December 2019

Introduction: Endothelin-1 (ET-1) is potent vasoconstrictive peptide and elevated ET-1 levels are associated with hypertension, endothelial dysfunction and atherosclerosis. Research on (ET-1) has demonstrated that elevated ET-1 levels in autosomal dominant polycystic kidney disease leads to systemic hypertension. The prevalence of simple renal cysts increases with age and the association with simple renal cyst and hypertension is not clear. The aim of this study was to investigate the ET-1 levels in patients with simple renal cyst and compare them with those in healthy adults.

Materials and methods: The study included patients that underwent laparoscopic renal cyst decortication in the Department of Urology and healthy controls. Serum and urinary ET-1 levels were measured before surgery and one month after it in the patients with simple renal cyst. Serum ET-1 levels were measured in healthy adult patients. Ambulatory blood pressure was measured in all patients. Glomerular filtration rate was measured according to the chronic kidney disease epidemiology collaboration formula.

Results: Thirty-two patients were included in the present study. Of these, 16 patients with simple renal cyst were allocated into group 1 and 16 healthy patients - in group 2. There was no significant difference between systolic and diastolic blood pressure between the groups (p=0.820 and p=0.618, respectively). Serum EL-1 levels were significantly lower in group 1 than those in group 2 (p=0.036). Interestingly, serum EL-1 levels were increased after laparoscopic cyst decortication and there was no significant difference with healthy patients (p=0.429).

Conclusions: The present study demonstrated that serum EL-1 level in patients with simple renal cyst was lower than that in healthy people. Further studies are needed to investigate the EL-1 levels in simple renal cyst patients.
Subchronic Central Administration of Cannabinoid Ligands Modulates Nociception in Bulbectomized Rats
Authors: Tashev Roman E. , Stavreva Galya Tz. , Velikova Margarita St.
Published: December 2019

Introduction: Endocannabinoid system is involved in neuropsychiatric disorders such as major depression. The bilaterally olfactory bulbectomized rat is widely used as an animal model of depression. The removal of the olfactory bulbs produces behavioural, physiological, and neurochemical alterations resembling clinical depression. There is increasing evidence that highlights the important role of cannabinoid signalling in depression and nociception.

Aim: To investigate the effect of CB1 receptor agonist HU 210 and CB1 receptor antagonist SR 141716A administered icv subchronically (for 7 days) on nociception of rats with model of depression - bilateral olfactory bulbectomy (OBX).

Material and methods: Experimental model of depression - bilateral olfactory bulbectomy (OBX). Bilaterally olfactory bulbectomized rats were used as an experimental model of depression. HU 210 (5 µg) or SR 141716A (3 µg) were infused icv for 7 consecutive days, starting 15 days after the olfactory bulbectomy. Nociception was examined by applying paw pressure test (analgesy-meter) evaluating the rat pain threshold. On day 7, five minutes after the last microinjection, the rats were tested in an analgesy-meter and their mechanically evoked pain responses were measured in arbitrary units (AU).

Results: Microinjections of HU 210 (5 µg) significantly decreased the pain threshold in olfactory bulbectomized rats, while SR 141716A (3 µg) exerted antinociceptive effect by increasing the pain threshold.

Conclusions: Data point to an involvement of CB1 receptors in depression-like behaviour and nociception in olfactory bulbectomized rats and support the data for the association between depressive disorder and pain pathways.
Optimization of pharmacotherapy of patients with prostate adenoma with hormonal and metabolic disordes: correction of vitamin D deficiency with “Aquadetrim”
Authors: Bratchikov Oleg I. , Tyuzikov Igor A. , Artishchev Sergey O.
Published: December 2019

Introduction: Modern studies demonstrate an epidemiological and pathogenetic role of systemic hormonal and metabolic disorders in men with prostate adenoma (PA), so it is obvious that a pharmacotherapeutic correction of these disorders can increase the efficacy of the traditional therapy of the disease.

Aim of study: To investigate the frequency, relationships among themselves and with PA local parameters of key systemic hormonal and metabolic disorders (obesity, insulin resistance, testosterone deficiency, vitamin D deficiency) and to develop practical algorithms for optimizing diagnosis and management based on an integrative approach.

Material and Methods: The results of a comprehensive examination of 160 patients with PA (main group; average age 62.3 ± 4.2 years) and 30 healthy men without PA of the same age (control group), including: collection of anamnesis and complaints; questionnaires; physical, hormonal and sonographic studies, – are presented. Pharmacotherapeutic correction methods were tested in some patients of the main group. The data was processed using descriptive and comparative statistics.

Results and Discussion: In the patients with PA, a significantly higher frequency of concomitant systemic hormonal and metabolic disorders formed at a younger age was established, compared to the men without PA, and significantly worse local characteristics of PA compared to the patients with PA without such (p < 0.05). Reliable connections of some studied systemic hormonal and metabolic disorders with one another and with local parameters of PA (p < 0.05) were revealed. A more severe vitamin D deficiency in the patients with PA compared to the control group was revealed, and the safety and a significant positive effect of its drug compensation on the parameters of hormonal and metabolic status and PA in D-deficient men with PA were shown (p < 0.05).

Conclusion: The results of the study confirm an important role of the studied systemic hormonal and metabolic disorders in the pathogenesis of PA and the need for their diagnosis and pharmacotherapeutic correction in all patients with PA on the basis of an integrative approach, according to the proposed algorithms.
Comparative study of qualitative and quantitative characters of grape cultivar 'Mavrodafni' (Vitis vinifera L.) and 'Renio' grown in different regions of the Protected Designation of Origin Mavrodafni Patras
Authors: Biniari Katerina , Daskalakis Ioannis , Bouza Despoina , Stavrakaki Maritina
Published: December 2019

'Mavrodafni' (Vitis vinifera L.) is considered one of the oldest grapevine cultivars indigenous to the Greek vineyards, with western Peloponnese being its primary centre of cultivation. 'Renio' is considered to be either a biotype of 'Mavrodafni' or an altogether different cultivar. Both 'Mavrodafni' and 'Renio' can be found in the vineyards of the areas of cultivation, since 'Renio' is considered to be more productive compared to 'Mavrodafni' and, for this reason, it has gradually replaced 'Mavrodafni' from cultivation over the course of time.

'Mavrodafni' and 'Renio' contain appreciable amounts of quality characters of grape and must in terms of total polyphenol and total anthocyanins content in berry skins, depending on the different regions where they are cultivated and they would be worthy of further study and use for the production of different types of wines.
Thermal Capsulorrhaphy
Authors: Levine William N , Bigliani Louis U , Ahmad Christopher S
Published: December 2019

Thermal capsulorrhaphy was introduced over the past decade and enjoyed several years of enthusiastic support. However, longer follow-up has demonstrated inconsistent clinical results and concern about major complications.
New Insights Into the Biology of Fracture Healing
Authors: Stein Haim , Perren Stephaen M , Mosheiff Rami
Published: December 2019

Distraction and segment transport are accepted treatments for fracture management. This study shows distraction as the more efficient method for osteoinduction.
Alternatives for MRSA Treatment in the Pediatric Patient
Authors: Lopez Ibis D
Published: December 2019

Based on its pharmacokinetic and safety profiles, linezolid offers a therapeutic alternative for resistant gram-positive bacteria.
Factors Associated With Good Outcome Using Lateral Mass Plate Fixation
Authors: Katonis Pavlos , Papadopoulos Charalambos A , Muffoletto Anthony , Papagelopoulos Panayiotis J , Hadjipavlou Alexander G
Published: December 2019

abstract

The immediate and long-term outcomes of 70 consecutive patients who underwent subaxial lateral mass fixation between June 1996 and June 2001 were reviewed. Intraoperative fluoroscopy and somatosensory evoked potential (SEP) monitoring were used in all patients. Immediate postoperative computed tomography (CT) was performed to determine screw trajectory and placement. Follow-up ranged from 2 to 7 years.

Postoperative CT showed 206 (58%) of 356 screws had unicorticate and 42% bicorticate purchase. Furthermore, 96 (27%) screws had suboptimal trajectory, but only 5 of these screws minimally penetrated the foramen transversarium without resultant vascular or neurological sequelae. A sudden unilateral intraoperative SEP amplitude decrease during screw placement in 2 patients resolved with screw removal and alteration of screw trajectory. The overall fusion success rate was 91.5% and screw pull-out developed in 2 patients.

The recommended drilling technique and trajectory 15°-25° rostral in the sagittal plane, 20°-30° lateral in the axial plane), supplemented bone grafting, and intraoperative SEP monitoring are all associated with good screw placement, fusion, and neurological outcome and are recommended for all lateral mass fusion procedures.
Surgical Decompression for Cervical Spondylotic Myelopathy: Correlation Between Operative Outcomes and MRI of the Spinal Cord
Authors: Papadopoulos Charalambos A , Karonis Pavlos , Papagelopoulos Panayiotis J , Karampekios Spyridon , Hadjipavlou Alexander G
Published: December 2019

abstract

Forty-two patients who underwent decompressive surgery for cervical spondylotic myelopathy were studied. The pre- and postoperative magnetic resonance imaging (MRI) findings and the Japanese Orthopedic Association score were analyzed to evaluate whether the different appearances of intramedullary high-signal intensity on T2-weighted MRI are related to the surgical prognosis. Magnetic resonance imaging signal intensities were classified as type 0 if no intramedullary high-signal intensity on T2-weighted images was noted, type 1 if high-signal intensity involved only one segment, and type 2 if high-signal intensity extended over two segments. Statistical analyses of the recovery ratio showed that type 0 and type 1 intramedullary high-signal intensity indicates better prognosis than type 2.
Fixation of Distal Tibial Fractures With Intraarticular Extension Using Double Overlapping Plates
Authors: Christodoulou Anastasios , Ploumis Avraam , Terzidis Ioannis , Givissis Panagiotis , Hatzokos Ippokratis , Pournaras John
Published: December 2019

Double overlapping plate configuration for the treatment of low energy, extensile, diaphyseal and metaphyseal fractures of the distal tibia is a reliable fixation method.
Postoperative Hypertension
Authors: Weant Kyle A , Flynn Jeremy D , Smith Kelly M
Published: December 2019

Postoperative hypertension is a serious complication following surgery that can result in significant complications if left untreated.
Fractured Childhoods, Identities in Transit: Humanitarian Aid for Central European Refugees from the United Kingdom
Authors: Garrido Caballero Magdalena
Published: December 2019

The aim of this study is to address the situation of one of the most vulnerable social collectives: Central European refugee children and youths who fled the territories occupied by the Third Reich, thanks to the help provided by large number of private or public organizations, which resulted in the reception of about ten thousand refugees in the United Kingdom at the beginning of World War II. To this end, diverse documents have been analysed from archives such as The National Archive and The British Library, in order to learn more about this human drama and its impact upon international politics, as well as the role played by the British Government.
Stability of Ultrathin Amorphous Calcium Phosphate Artificial Enamel Sheets under Simulated Intraoral Environment Condition
Authors: Kato Nobuhiro , Hirai Mizuki , Yamamoto Ei , Hontsu Shigeki
Published: December 2019

Dental materials purely composed of calcium phosphate are ideal for the dental medicine. We have been developing ultrathin amorphous calcium phosphate (ACP) sheets for enamel repair. In this study, long term stability of the ultrathin ACP sheets applied on enamel surfaces which kept in a simulated intraoral condition for 21 days was evaluated. Surface morphologies of the ACP sheets were observed by optical images. A boundary condition between the ACP sheet and the enamel was evaluated by cross-sectional SEM image. A durability of the ACP sheet was evaluated by a brushing test conducted after 21 days incubation. As the result of these evaluations, it was confirmed that the ACP sheets were stable even after long-term incubation under the simulated intraoral environment condition.
The Effect of Green Betle Leaf Gel (Piper Betle Leaf) to Total Antioxidant Capacity (TAC) Level after Scaling and Root Planing (SRP) Treatment
Authors: Rusminah Nunung , Rusyanti Yanti , Susanto Agus , Rini Tisye Chandra
Published: December 2019

Abstract. Green betel leaf gel (Piper betle leaf) has an antimicrobial, antiseptic and antioxidant activity. An imbalance between antioxidants and ROS in the oral cavity have been implicated as one of the progressive or pathogenic factor for periodontal disease. Antimicrobial topical agent delivery may be provided as a supportive therapy for periodontal treatment after scaling and root planing. The purpose of this research is to analyze the effect of green betle leaf gel (Piper betle leaf) to Total Antioxidant Capacity (TAC) level gingival crevicular fluids after scaling and root planing treatment in chronic periodontitis patients. This research is a quasi experimental with pretest and posttest, split mouth. A total of 14 subjects followed this study. The parameters measured were TAC levels gingival crevicular fluids before and after treatment with ELISA examination. Green betel leaf gel was applied to the pocket on the test side after scaling and root planing. Data analysis using Wilcoxon test with p <0.05, and Mann-Whitney test with p <0.05. TAC levels of gingival crevicular fluids increased on day 14 on both sides, on the test side there was a significant increase (p = 0.002) while on the control side the increase was not significant. Green betel leaf gel has an effect to increase TAC level gingival crevicular fluids after scaling and root planing in chronic periodontitis patients.
The Influence of Alteration of kVp and mAs towards the Image Quality of Acrylic Using CBCT
Authors: Azhari Azhari , Hutasoit Yohanes , Haryanto Freddy
Published: December 2019

CBCT is a modernized technology in producing radiograph image on dentistry. The image quality excellence is very important for clinicians to interpret the image, so the result of diagnosis produced becoming more accurate, appropriate, thus minimizing the working time. This research was aimed to assess the image quality using the blank acrylic phantom polymethylmethacrylate (PMMA) (C­5H8O2)n in the density of 1.185 g/cm3 for evaluating the homogeneity and uniformity of the image produced. Acrylic phantom was supported with a tripod and laid down on the chin rest of the CBCT device, then the phantom was fixed, and the edge of the phantom was touched by the bite block. Furthermore, the exposure of the X-ray was executed toward the acrylic phantom with various kVp and mAs, from 80 until 90, with the range of 5 kV and the variation of mA was 3, 5, and 7 mA respectively. The time exposure was kept constant for 25 seconds. The samples were taken from CBCT acrylic images, then as much as 5 ROIs (Region of Interest) was chosen to be analyzed. The ROIs determination was analyzed by using the ImageJ® software for recognizing the influence of kVp and mAs towards the image uniformity, noise and SNR. The lowest kVp and mAs had the result of uniformity value, homogeneity and signal to noise ratio of 11.22; 40.35; and 5.96 respectively. Meanwhile, the highest kVp and mAs had uniformity value, homogeneity and signal to noise ratio of 16.96; 26.20; and 5.95 respectively. There were significant differences between the image uniformity and homogeneity on the lowest kVp and mAs compared to the highest kVp and mAs, as analyzed with the ANOVA statistics analysis continued with the t-student post-hoc test with α = 0.05. However, there was no significant difference in SNR as analyzed with the ANOVA statistic analysis. The usage of the higher kVp and mAs caused the improvement of the image homogeneity and uniformity compared to the lower kVp and mAs.
Preparation and Characterization of Terpenoid-Encapsulated PLGA Microparticles and its Antibacterial Activity against Enterococcus faecalis
Authors: Nurdin Denny , Hardiansyah Andri , Chaldun Elsy Rahimi , Fikkriyah Anti Khoerul , Dharsono Hendra Dian Adhita , Kurnia Dikdik , Satari Mieke Hemiawati
Published: December 2019

Exploration of natural compound for the treatment of dental-related problems are gaining of interest for enhancing therapeutic efficacy of the drugs delivery system. In this study, we have prepared terpenoid, which have been isolated from Myrmecodia pendens Merr & Perry from Papua Island, Indonesia, to be encapsulated in Polylactic-co-glycolic acid (PLGA), as the most widely used biodegradable polymer for biomedical applications, through one step single-emulsion method followed by subsequent coating by poly (vinyl alcohol) (PVA). The resultant of terpenoid-loaded PLGA microparticles were characterized systematically through scanning electron microscope and Fourier-transform infrared spectroscopy. In vitro drug release test was evaluated through dialysis method. Antibacterial test was conducted against Enterococcus faecalis as a model for persistent bacteria that causes root canal infections. The results showed that terpenoid-loaded PLGA microparticles were developed in spherical morphology with an average particle size of around 1-2μm. Terpenoid released from PLGA compartment at pH 6.5 and temperature of 37°C through a controlled-release profile mechanism with enhanced prolonged release. The bacterial assay result showed that terpenoid-loaded PLGA microparticles could reduce Enterococcus faecalis, effectively. Eventually, these result show that terpenoid-loaded PLGA microparticles as unique natural product-based extract could be developed as a potential naturally-based drug for dental-related diseases applications.
Improvement of Bone Filler Materials Using Granular Calcium Sulfate Dihydrate-Gelatin-Polycaprolactone Composite
Authors: Utami Difa Putri , Sunarso Sunarso , Eriwati Yosi Kusuma , Siti Triaminingsih , Indrani Decky Joesiana , Innawaty Dessy
Published: December 2019

Calcium sulfate dihydrate (CSD) cement has been used as bone void filler and antibiotic carrier for many years. However, the main drawback of CSD cement is its brittleness that limits its handling property. Thus, the aim of this study is to fabricate granular CSD cement-gelatin-polycaprolactone (CSD-Gel-PCL) to improve handling property. To prepare CSD-Gel-PCL composite, granular CSD was prepared from calcium sulfate hemihydrate (CaSO4.0.5H2O; CSH) and distilled water with water/powder (W/P) ratio of 0.5. The CSD cement was crushed and sieved into 300-500 μm. The obtained granular CSD was then mixed with 3 wt.%, 5 wt.% and 7 wt.% gelatin solution which previously mixed with PCL (50 wt% PCL, 50 wt% gelatin), followed by freeze drying for 48 hours. The CSD granules were able to bind together after the addition of gelatin and PCL matrix. After freeze drying, the CSD granules were not easy to remove from the composite body. Scanning electron microscopy (SEM) analysis revealed that CSD granules were surrounded by polymer matrix in all 3 different specimens in which the higher gelatin concentration, the more the matrix found between the granules. Mechanical evaluation suggested that all of the specimens showed the same stress-strain curve pattern. The CSD-Gel-PCL composite with 7 wt% gelatin has the highest strength compared with the other specimens. Stress-strain curves indicated that combination of CSD granules, gelatin and PCL has produced bone filler with improved handling property.