bluuebunny/crossref_metadata_2025 huggingface dataset:
Responses of Cynanchum taiwanianum and Its Bioactive Compound Biosynthesis to Levels of Nitrogen and Potassium Fertilization
Authors: Tseng Han-Mei , Lu Tzy-Ming , Ng Lean-Teik
Published: January 2022

Cynanchum taiwanianum is an important plant used in traditional medicine. The increasing demand and lack of information regarding its cultivation have become concerns for sustainability. This study examined the effects of nitrogen and potassium fertilization rates on the growth and biosynthesis of main bioactive compounds, including cynandione A and polyphenolic compounds, in field-cultivated C. taiwanianum. Two field experiments were conducted using three levels of nitrogen (N100, N150 and N200) and three levels of potassium (K100, K150 and K200) treatments. The experimental variables were either N or K fertilizer. The results showed that, aside from N200, N and K fertilization significantly increased C. taiwanianum shoot and tuber biomass. High N fertilization resulted in low total phenolic and total flavonoid contents in shoots and tubers, but the effects of K fertilization were minimal. Cynandione A, an important bioactive compound, was only detected in tubers; its content were enhanced with the increasing K fertilization, but reduced with excess N fertilization (N200). Although N and K fertilizers are important for C. taiwanianum tuber production, the yield of cynandione A was associated with K but not N fertilization rates. These results provide some essential information for the optimal production of C. taiwanianum tubers and functional compounds. Further studies are required to examine the mechanism(s) of cynandione A biosynthesis and its compartmentation in plant tissues.
Exercise, Urban Food Production, Preparation and Consumption: Implications, Benefits and Risks to Grow-Your-Own (GYO) Gardeners
Authors: Stubberfield Jonathan , Troldborg Mads , Ander Louise , Crout Neil , Young Scott D. , Hough Rupert L.
Published: January 2022

This study is the first to consider, and estimate, the influence of gardening routines on exposures to both health benefits and health risks. This holistic approach helped to contrast the healthy lifestyle of gardening with health risks from exposures to potentially toxic elements such as Cd and Pb in urban environments. A total of 120 participants who grew their own produce in an urban setting were recruited to the study. A detailed questionnaire was developed that included sections on gardening activity, cultivation and consumption of produce, consumption of commercially grown produce, and other lifestyle factors. Administered alongside the questionnaire was the Short Form 36 (v2) as a standardised tool for measuring physical and mental health. Fruit and vegetable consumption was found to be correlated with the amount of gardening individuals did in autumn/winter and was greater than fruit and vegetable consumption, on average, in the UK general population. Levels of physical activity were also found to be higher in our study than regional averages, whilst BMI was lower than average. This is the first study to find a relationship between gardening more regularly (in autumn/winter) and the physical component of the Short Form 36, and this relationship was elevated compared to non-gardening populations. The physical component scores from this study were also significantly higher for older participants, compared to means from a Western population. This finding supports studies suggesting that gardening may be more beneficial for the elderly generation. These benefits were assessed in the context of potential exposures estimated from the type and frequency of produce being consumed. The benefit of maintaining a healthy lifestyle is likely to outweigh the health risks of gardening on soils mildly contaminated with Cd and Pb but requires formal consideration within a risk management framework.
De Novo Transcriptome Assembly and SNP Discovery for the Development of dCAPS Markers in Oat
Authors: Kim Tae-Heon , Yoon Young-Mi , Park Jin-Cheon , Park Jong-Ho , Kim Kyong-Ho , Kim Yang-Kil , Son Jae-Han , Park Tae-Il
Published: January 2022

Cultivated oat (Avena sativa L.) is an important cereal crop that has captured interest worldwide due to its nutritional properties and associated health benefits. Despite this interest, oat has lagged behind other cereal crops in genome studies and the development of DNA markers due to its large and complex genome. RNA-Seq technology has been widely used for transcriptome analysis, functional gene study, and DNA marker development. In this study, we performed the transcriptome sequencing of 10 oat varieties at the seedling stage using the Illumina platform for the development of DNA markers. In total, 31,187,392~41,304,176 trimmed reads (an average of 34,322,925) were generated from 10 oat varieties. All of the trimmed reads of these varieties were assembled and generated, yielding a total of 128,244 assembled unigenes with an average length of 1071.7 bp and N50 of 1752 bp. According to gene ontology (GO) analysis, 30.7% of unigenes were assigned to the “catalytic activity” of the parent term in the molecular function category. Of the 1273 dCAPS markers developed using 491 genotype-specific SNPs, 30 markers exhibiting polymorphism in 28 oat varieties were finally selected. The transcriptome data of oat varieties could be used for functional studies about the seedling stage of oat and information about sequence variations in DNA marker development. These 30 dCAPS markers will be utilized for oat genetic analysis, cultivar identification, and breeders’ rights protection.
Antimicrobial Stewardship in College and University Health Settings: A Public Health Opportunity
Authors: Dambrino Kathryn L. , Green Montgomery
Published: January 2022

Antimicrobial resistance poses a significant threat to public health and safety across the globe. Many factors contribute to antibiotic resistance, most especially are the concerns of excessive prescribing and misuse of antibiotics. Because patient expectations for antibiotics may contribute to prescriber pressures, experts recommend targeting antimicrobial stewardship (AMS) education efforts towards prescribers as well as patients in outpatient settings. Undergraduate university students are a unique and promising target population for AMS efforts because they are in a transformative life stage of social, cognitive, and physical development in which they are learning to independently care for themselves without the presence or influence of parents. By introducing AMS education during this transition, university students may adopt positive antibiotic use behaviors that they will carry throughout their lives. Not only will their personal health be improved, but widespread adoption of AMS in university settings may have a broader effect on public health of present and future generations. Despite public health opportunities, minimal research has examined AMS in university health settings. This article explores current evidence on knowledge, attitudes, and use of antibiotics among university students and discusses opportunities for AMS initiatives in college and university health settings.
Multi-Drug and β-Lactam Resistance in Escherichia coli and Food-Borne Pathogens from Animals and Food in Portugal, 2014–2019
Authors: Costa Miguel Mendes , Cardo Miguel , Soares Patricia , Cara d’Anjo Maria , Leite Andreia
Published: January 2022

Animal and food sources are seen as a potential transmission pathway of antimicrobial resistance (AMR) to humans. The aim of this study is to describe Campylobacter, Salmonella, and commensal Escherichia coli multi-drug resistance (MDR) in the food chain between 2014 and 2019 in Portugal. AMR surveillance data from food-producing animals and food were assessed. MDR relative frequencies were estimated by bacterial genus and year. AMR profiles were created using observations of resistance to antimicrobial classes from each isolate. Antimicrobial susceptibility testing results were clustered using k-modes. Clusters were described by population, AMR classification, β-lactamases, sample stage, sample type, season, and year. Overall, MDR was more prevalent for E. coli, ranging from 74–90% in animal and 94–100% in food samples. MDR was found to be more widespread in resistance profiles that were common among E. coli and Salmonella isolates and in those exclusively observed for E. coli, frequently including (fluoro)quinolones and cephalosporins resistance. β-lactam resistance was observed around 75% to 3rd/4th-generation cephalosporins in E. coli. Clusters suggest an escalating MDR behaviour from farm to post-farm stages in all bacteria and that Salmonella (fluoro)quinolones resistance may be associated with broilers. These findings support policy and decision making to tackle MDR in farm and post-farm stages.
Antimicrobial Photosensitizing Material Based on Conjugated Zn(II) Porphyrins
Authors: Santamarina Sofía C. , Heredia Daniel A. , Durantini Andrés M. , Durantini Edgardo N.
Published: January 2022

The widespread use of antibiotics has led to a considerable increase in the resistance of microorganisms to these agents. Consequently, it is imminent to establish new strategies to combat pathogens. An alternative involves the development of photoactive polymers that represent an interesting strategy to kill microbes and maintain aseptic surfaces. In this sense, a conjugated polymer (PZnTEP) based on Zn(II) 5,10,15,20-tetrakis-[4-(ethynyl)phenyl]porphyrin (ZnTEP) was obtained by the homocoupling reaction of terminal alkyne groups. PZnTEP exhibits a microporous structure with high surface areas allowing better interaction with bacteria. The UV-visible absorption spectra show the Soret and Q bands of PZnTEP red-shifted by about 18 nm compared to those of the monomer. Also, the conjugate presents the two red emission bands, characteristic of porphyrins. This polymer was able to produce singlet molecular oxygen and superoxide radical anion in the presence of NADH. Photocytotoxic activity sensitized by PZnTEP was investigated in bacterial suspensions. No viable Staphylococcus aureus cells were detected using 0.5 µM PZnTEP and 15 min irradiation. Under these conditions, complete photoinactivation of Escherichia coli was observed in the presence of 100 mM KI. Likewise, no survival was detected for E. coli incubated with 1.0 µM PZnTEP after 30 min irradiation. Furthermore, polylactic acid surfaces coated with PZnTEP were able to kill efficiently these bacteria. This surface can be reused for at least three photoinactivation cycles. Therefore, this conjugated photodynamic polymer is an interesting antimicrobial photoactive material for designing and developing self-sterilizing surfaces.
Development of New Antimicrobial Oleanonic Acid Polyamine Conjugates
Authors: Khusnutdinova Elmira F. , Sinou Véronique , Babkov Denis A. , Kazakova Oxana , Brunel Jean Michel
Published: January 2022

A series of oleanolic acid derivatives holding oxo- or 3-N-polyamino-3-deoxy-substituents at C3 as well as carboxamide function at C17 with different long chain polyamines have been synthesized and evaluated for antimicrobial activities. Almost all series presented good to moderate activity against Gram-positive S. aureus, S. faecalis and B. cereus bacteria with minimum inhibitory concentration (MIC) values from 3.125 to 200 µg/mL. Moreover, compounds possess important antimicrobial activities against Gram-negative E. coli, P. aeruginosa, S. enterica, and EA289 bacteria with MICs ranging from 6.25 to 200 µg/mL. The testing of ability to restore antibiotic activity of doxycycline and erythromycin at a 2 µg/mL concentration in a synergistic assay showed that oleanonic acid conjugate with spermine spacered through propargylamide led to a moderate improvement in terms of antimicrobial activities of the different selected combinations against both P. aeruginosa and E. coli. The study of mechanism of action of the lead conjugate 2i presenting a N-methyl norspermidine moiety showed the effect of disruption of the outer bacterial membrane of P. aeruginosa PA01 cells. Computational ADMET profiling renders this compound as a suitable starting point for pharmacokinetic optimization. These results give confidence to the successful outcome of bioconjugation of polyamines and oleanane-type triterpenoids in the development of antimicrobial agents.
Remote Practice Methods of Survey Education for HBIM in the Post-Pandemic Era: Case Study of Kuiwen Pavilion in the Temple of Confucius (Qufu, China)
Authors: Xi Wang , Cong Wu
Published: January 2022

The Field Trip for Measured Survey of Built Heritage carried out by Tianjin University every summer aims to educate students in each practice session, i.e., on-site data acquisition, condition investigation, classification of the component library, taking observation notes, and accomplishing HBIM deliverables. Under the risks posed by the ongoing COVID-19 pandemic, the students could not leave the campus as a provisional arrangement. Only a team of five people was allowed to visit the Kuiwen Pavilion in the Temple of Confucius (Qufu, China). Therefore, the field trip for students had to be replaced with remote solutions, which consists of the following methods: on-site data acquisition; post-processing; online education, observation, modeling, delivery. Kuiwen Pavilion in the Temple of Confucius is a library with the official architectural style of the Ming and Qing Dynasties (14th to 20th century), for which building regulations are commonly recognized, and are suitable for survey education. In this context, this article focuses on the remote practice methods applied and tested throughout the case study. During the practice of the course, students who managed to finish the course, through the virtual tours and other online methods, finally achieved delivery of the HBIM models.
Ferrites and Nanocrystalline Alloys Applied to DC–DC Converters for Renewable Energies
Authors: Ruiz Dante , Ortíz Jorge , Moreno Edgar , Fuerte Claudio , Venegas Vicente , Vargas Alejandro , Vergara Héctor
Published: January 2022

The medium frequency transformer (MFT) with nanocrystalline alloys is quintessential in new DC–DC converters involved in various front-end applications. The center piece to achieve high-performance, efficient MFTs is the core. There are various options of core materials; however, no deep information is available about which material characteristics and design procedure combo are best to get high performance MFTs while operating at maximal power density. To provide new insights about interrelation between the selection of the core material with the compliance technical specifications, differently to other proposals, this research work aims to design and build, with the same methodology, two MFT prototypes at 20 kHz, with nanocrystalline and ferrite cores, to highlight power density, and overall performance and cost, as matching design criteria. As the experimental results show, a nanocrystalline core has the highest power density (36.91 kW/L), designed at 0.8 T to obtain low losses at 20 kHz, achieving an efficiency of 99.7%. The power density in the ferrite MFT is 56.4% lower than in the nanocrystalline MFT. However, regarding construction cost, the ferrite MFT is 46% lower, providing this a trend towards low-cost DC–DC converters. Finally, high power density in MFTs increases the power density of power DC–DC converters, which have relevant applications in fuel cell-supplied systems, renewable energies, electric vehicles, and solid-state transformers.
Mechanical and Thermomechanical Properties of Clay-Cowpea (Vigna Unguiculata Walp.) Husks Polyester Bio-Composite for Building Applications
Authors: Anosike-Francis Esther Nneka , Ubi Paschal Ateb , Obianyo Ifeyinwa Ijeoma , Kalu-Uka Godwin Mong , Bello Abdulhakeem , Ofem Michael Ikpi , Olorunnisola Abel Olajide , Onwualu Azikiwe Peter
Published: January 2022

This study investigates the feasibility of creating a clay polymer-based composite using cowpea husk (CPH) as filler for production of roof tiles. Polymeric composites were fabricated by mixing unsaturated polyester (UPT) resin with cowpea husk at different filler weights and curing. A hybrid composite was produced with the addition of 3 wt.% clay and all samples produced were subjected to flexural, hardness and dynamic mechanical analysis (DMA) tests. The effect of clay addition on the mechanical and thermo-mechanical behaviour of formulated composites was investigated. The morphological analysis of the mono and hybrid system shows a rough and coarse inhomogeneous surface with voids created due to the addition of CPH filler for the mono reinforced and clay uniformly filling the voids that were created by the CPH in the hybrid composite. It is observed that hardness, tensile modulus and flexural modulus of hybrid composites increase with an increase in the CPH contents, while the strength and flexural strength all decrease with filler content. The optimal composition was obtained using Grey relational analysis (GRA) at 18% CPH for both mono and hybrid composite. The results imply that the composite combination can be used in making rooftiles and/or also in applications where low strength is required.
Prediction of Solar Irradiance over the Arabian Peninsula: Satellite Data, Radiative Transfer Model, and Machine Learning Integration Approach
Authors: Alwadei Sahar , Farahat Ashraf , Ahmed Moataz , Kambezidis Harry D.
Published: January 2022

Data from a moderate resolution imaging spectroradiometer instrument onboard the Terra satellite along with a radiative transfer model and a machine learning technique were integrated to predict direct solar irradiance on a horizontal surface over the Arabian Peninsula (AP). In preparation for building appropriate residual network (ResNet) prediction models, we conducted some exploratory data analysis (EDA) and came to some conclusions. We noted that aerosols in the atmosphere correlate with solar irradiance in the eastern region of the AP, especially near the coastlines of the Arabian Gulf and the Sea of Oman. We also found low solar irradiance during March 2016 and March 2017 in the central (~20% less) and eastern regions (~15% less) of the AP, which could be attributed to the high frequency of dust events during those months. Compared to other locations in the AP, high solar irradiance was recorded in the Rub Al Khali desert during winter and spring. The effect of major dust outbreaks over the AP during March 2009 and March 2012 was also noted. The EDA indicated a correlation between high aerosol loading and a decrease in solar irradiance. The analysis showed that the Rub Al Khali desert is one of the best locations in the AP to harvest solar radiation. The analysis also showed the ResNet prediction model achieves high test accuracy scores, indicated by a mean absolute error of ~0.02, a mean squared error of ~0.005, and an R2 of 0.99.
Graphene Nanoplatelets: In Vivo and In Vitro Toxicity, Cell Proliferative Activity, and Cell Gene Expression
Authors: Salesa Beatriz , Tuñón-Molina Alberto , Cano-Vicent Alba , Assis Marcelo , Andrés Juan , Serrano-Aroca Ángel
Published: January 2022

Multi-layer graphene (2–10 layers), also called graphene nanoplatelets (GNPs), is a carbon-based nanomaterial (CBN) type with excellent properties desirable for many biomedical applications. Despite the promising advantages reported of GNPs, nanoscale materials may also present a potential hazard to humans. Therefore, in this study, the in vivo toxicity of these nanomaterials at a wide range of concentrations from 12.5 to 500 µg/mL was evaluated in the Caenorhabditis elegans model for 24 h (acute toxicity) and 72 h (chronic toxicity). Furthermore, their in vitro toxicity (from 0 to 10 µg/mL for 12 and 24 h), proliferative activity at 72 and 96 h, and their effect on the expression of thirteen genes in human keratinocytes HaCaT cells were studied. The physico-chemical and morphological aspects of the GNPs used in this study were analyzed by Raman scattering spectroscopy, electron microscopy, zeta potential as a function of pH, and particle size measurements by dynamic light scattering. The results of this study showed that GNPs showed in vivo non-toxic concentrations of 25 and 12.5 µg/mL for 24 h, and at 12.5 µg/mL for 72 h. Moreover, GNPs present time-dependent cytotoxicity (EC50 of 1.142 µg/mL and 0.760 µg/mL at 12 h and 24 h, respectively) and significant proliferative activity at the non-toxic concentrations of 0.005 and 0.01 μg/mL in the HaCaT cell line. The gene expression study showed that this multi-layer-graphene is capable of up-regulating six of the thirteen genes of human keratinocytes (SOD1, CAT, TGFB1, FN1, CDH1, and FBN), two more genes than other CBNs in their oxidized form such as multi-layer graphene oxide. Therefore, all these results reinforce the promising use of these CBNs in biomedical fields such as wound healing and skin tissue engineering.
Influence of Dry Friction on the Dynamics of Cantilevered Pipes Conveying Fluid
Authors: Guo Zilong , Ni Qiao , Wang Lin , Zhou Kun , Meng Xiangkai
Published: January 2022

A cantilevered pipe conveying fluid can lose stability via flutter when the flow velocity becomes sufficiently high. In this paper, a dry friction restraint is introduced for the first time, to evaluate the possibility of improving the stability of cantilevered pipes conveying fluid. First, a dynamical model of the cantilevered pipe system with dry friction is established based on the generalized Hamilton’s principle. Then the Galerkin method is utilized to discretize the model of the pipe and to obtain the nonlinear dynamic responses of the pipe. Finally, by changing the values of the friction force and the installation position of the dry friction restraint, the effect of dry friction parameters on the flutter instability of the pipe is evaluated. The results show that the critical flow velocity of the pipe increases with the increment of the friction force. Installing a dry friction restraint near the middle of the pipe can significantly improve the stability of the pipe system. The vibration of the pipe can also be suppressed to some extent by setting reasonable dry friction parameters.
Optimizing Field Body Fat Percentage Assessment in Professional Soccer Players
Authors: Martinez-Ferran Maria , Rafei Eleh , Romero-Morales Carlos , Pérez-Ruiz Margarita , Lam-Meléndez Alberto , Munguia-Izquierdo Diego , Pareja-Galeano Helios
Published: January 2022

Body composition is a determinant of performance in soccer. To estimate the body fat percentage (%BF), dual energy X-ray absorptiometry (DXA) is effective though this method is expensive and not readily accessible. This study examines the validity of widely used field methods based on anthropometric data and bioelectrical impedance analysis (BIA). Participants were 21 male Spanish First Division soccer players aged between 22 and 35 years. In each participant, body fat mass was determined by BIA and using 18 anthropometric equations including skinfold (SKF) measurements. DXA was used as reference. Correlation with DXA measurements was excellent for all equations and separate SKF measurements yet only moderate for BIA. However, only the equation recently developed for use in soccer players based on iliac crest and triceps SKFs showed no significant or standardized differences with DXA-derived %BF and these measurements also had the lowest bias. Our findings suggest that when DXA is not available, the best field method for %BF assessment in footballers is the equation based on iliac crest and triceps SKF. As another good option, we propose the sum of triceps, subscapular, supraspinal, and abdominal SKFs, as this combination also showed good correlation with DXA.
Smart Digital Forensic Readiness Model for Shadow IoT Devices
Authors: Fagbola Funmilola Ikeolu , Venter Hein S.
Published: January 2022

Internet of Things (IoT) is the network of physical objects for communication and data sharing. However, these devices can become shadow IoT devices when they connect to an existing network without the knowledge of the organization’s Information Technology team. More often than not, when shadow devices connect to a network, their inherent vulnerabilities are easily exploited by an adversary and all traces are removed after the attack or criminal activity. Hence, shadow connections pose a challenge for both security and forensic investigations. In this respect, a forensic readiness model for shadow device-inclusive networks is sorely needed for the purposes of forensic evidence gathering and preparedness, should a security or privacy breach occur. However, the hidden nature of shadow IoT devices does not facilitate the effective adoption of the most conventional digital and IoT forensic methods for capturing and preserving potential forensic evidence that might emanate from shadow devices in a network. Therefore, this paper aims to develop a conceptual model for smart digital forensic readiness of organizations with shadow IoT devices. This model will serve as a prototype for IoT device identification, IoT device monitoring, as well as digital potential evidence capturing and preservation for forensic readiness.
A Robust Control Algorithm of a Descent Vehicle Angular Motion in the Earth’s Atmosphere
Authors: Zubov Nikolay , Lapin Alexey , Ryabchenko Vladimir , Proletarsky Andrey , Selezneva Maria , Neusypin Konstantin
Published: January 2022

A new approach to synthesize a robust controller for the angular motion of the Earth lander by decomposition method of output modal control is proposed. A universal analytical solution for the problem of stabilizing the angular position of the lander is obtained. A comparative analysis of the presented algorithm with the currently used onboard algorithm for descent control of the manned spacecraft Soyuz is carried out. The advantages of the new algorithm relative to the existing algorithm are presented, both in terms of stabilization accuracy and the consumption of the working fluid of the control motors.
Novel Semantic-Based Probabilistic Context Aware Approach for Situations Enrichment and Adaptation
Authors: Lakehal Abderrahim , Alti Adel , Roose Philippe
Published: January 2022

This paper aims at ensuring an efficient recommendation. It proposes a new context-aware semantic-based probabilistic situations injection and adaptation using an ontology approach and Bayesian-classifier. The idea is to predict the relevant situations for recommending the right services. Indeed, situations are correlated with the user’s context. It can, therefore, be considered in designing a recommendation approach to enhance the relevancy by reducing the execution time. The proposed solution in which four probability-based-context rule situation items (user’s location and time, user’s role, their preferences and experiences) are chosen as inputs to predict user’s situations. Subsequently, the weighted linear combination is applied to calculate the similarity of rule items. The higher scores between the selected items are used to identify the relevant user’s situations. Three context parameters (CPU speed, sensor availability and RAM size) of the current devices are used to ensure adaptive service recommendation. Experimental results show that the proposed approach enhances accuracy rate with a high number of situations rules. A comparison with existing recommendation approaches shows that the proposed approach is more efficient and decreases the execution time.
Privacy-Preserving Federated Learning Using Homomorphic Encryption
Authors: Park Jaehyoung , Lim Hyuk
Published: January 2022

Federated learning (FL) is a machine learning technique that enables distributed devices to train a learning model collaboratively without sharing their local data. FL-based systems can achieve much stronger privacy preservation since the distributed devices deliver only local model parameters trained with local data to a centralized server. However, there exists a possibility that a centralized server or attackers infer/extract sensitive private information using the structure and parameters of local learning models. We propose employing homomorphic encryption (HE) scheme that can directly perform arithmetic operations on ciphertexts without decryption to protect the model parameters. Using the HE scheme, the proposed privacy-preserving federated learning (PPFL) algorithm enables the centralized server to aggregate encrypted local model parameters without decryption. Furthermore, the proposed algorithm allows each node to use a different HE private key in the same FL-based system using a distributed cryptosystem. The performance analysis and evaluation of the proposed PPFL algorithm are conducted in various cloud computing-based FL service scenarios.
Prediction of Process Quality Performance Using Statistical Analysis and Long Short-Term Memory
Authors: Pheng Tola , Chuluunsaikhan Tserenpurev , Ryu Ga-Ae , Kim Sung-Hoon , Nasridinov Aziz , Yoo Kwan-Hee
Published: January 2022

In the manufacturing industry, the process capability index (Cpk) measures the level and capability required to improve the processes. However, the Cpk is not enough to represent the process capability and performance of the manufacturing processes. In other words, considering that the smart manufacturing environment can accommodate the big data collected from various facilities, we need to understand the state of the process by comprehensively considering diverse factors contained in the manufacturing. In this paper, a two-stage method is proposed to analyze the process quality performance (PQP) and predict future process quality. First, we propose the PQP as a new measure for representing process capability and performance, which is defined by a composite statistical process analysis of such factors as manufacturing cycle time analysis, process trajectory of abnormal detection, statistical process control analysis, and process capability control analysis. Second, PQP analysis results are used to predict and estimate the stability of the production process using a long short-term memory (LSTM) neural network, which is a deep learning algorithm-based method. The present work compares the LSTM prediction model with the random forest, autoregressive integrated moving average, and artificial neural network models to convincingly demonstrate the effectiveness of our proposed approach. Notably, the LSTM model achieved higher accuracy than the other models.
TNF-α, IL-1β, MMP-8 Crevicular Profile in Patients with Chronic Kidney Disease and Periodontitis
Authors: Andronovici Alina Maria , Caruntu Irina-Draga , Onofriescu Mihai , Hurjui Loredana Liliana , Giusca Simona-Eliza , Covic Andreea Simona , Braescu Radu , Foia Liliana-Georgeta
Published: January 2022

Increasing evidence sustains the potential of periodontitis as a risk factor for chronic kidney disease (CKD). Our study aimed to analyze several periodontal specific inflammatory biomarkers within the gingival crevicular fluid (GCF) of patients with CKD, compared to patients with normal kidney function, providing an inflammatory profile of the dialysis patient. The study comprised 79 patients divided into: group 1 (59 subjects with periodontitis and CKD) and group 2 (20 patients with periodontitis, without other systemic conditions). Clinical diagnosis was performed via dental and periodontal examination. GCF samples were collected from each patient, and the levels of TNF-α, IL-1β and MMP-8 were determined by using ELISA assay. In group 1, the average values were: 22.85 ± 5.87 pg/mL for TNF-α, 33.00 ± 39.68 pg/mL for IL-1β and 18.80 ± 27.75 ng/mL for MMP-8. In group 2, the mean values were: 2.10 ± 1.34 pg/mL for TNF-α, 0.71 ± 2.42 pg/mL for IL-1β and 5.35 ± 0.37 ng/mL for MMP-8. Statistical analysis revealed significant differences between groups as referring to all three biomarkers and, TNF-α and MMP-8, in certain stages of periodontitis. The level of TNF-α, IL-1β and MMP-8 points out the increased inflammatory status of the dialysis patient with PD, supporting the mutual connection of the two pathologies.
Rock Samphire, a Candidate Crop for Saline Agriculture: Cropping Practices, Chemical Composition and Health Effects
Authors: Karkanis Anestis , Polyzos Nikolaos , Kompocholi Maria , Petropoulos Spyridon A.
Published: January 2022

The recent market trends for functional healthy foods have rekindled the interest in wild edible species and created a market niche for high added value products. The current supply, mainly supported by plants collected from the wild, cannot meet increasing market needs; therefore, it is of major importance to establish cropping protocols and further valorize wild plants for culinary and industrial applications. Sea fennel is a wild edible halophyte that is an important ingredient in local cuisines and is also used in folk medicine for its beneficial health effects. Its valorization has not been commercially explored on a great scale and more efforts are needed to integrate the species in farming systems. The present review compiles the most recent reports regarding the farming practices that could allow for the establishment of cultivation protocols for farmers, while the main constraints that hinder the further exploitation of the species are also presented. Moreover, this review presents the most up-to-date information regarding the chemical composition (e.g., chemical composition of the aerial parts and volatile compounds in essential oils) and the health-related effects of various plant parts (e.g., antimicrobial, insecticidal and anticholinesterase activities) aiming to reveal possible alternative uses that will increase the added value of the species and will contribute to its commercial exploitation. Finally, the future remarks and the guidelines that have to be followed are also discussed.
Dynamic Network Formation for FSO Satellite Communication
Authors: Marbel Revital , Yozevitch Roi , Grinshpoun Tal , Ben-Moshe Boaz
Published: January 2022

Satellite network optimization is essential, particularly since the cost of manufacturing, launching and maintaining each satellite is significant. Moreover, classical communication optimization methods, such as Minimal Spanning Tree, cannot be applied directly in dynamic scenarios where the satellite constellation is constantly changing. Motivated by the rapid growth of the Star-Link constellation that, as of Q4 2021, consists of over 1600 operational LEO satellites with thousands more expected in the coming years, this paper focuses on the problem of constructing an optimal inter-satellite (laser) communication network. More formally, given a large set of LEO satellites, each equipped with a fixed number of laser links, we direct each laser module on each satellite such that the underlying laser network will be optimal with respect to a given objective function and communication demand. In this work, we present a novel heuristic to create an optimal dynamic optical network communication using an Ant Colony algorithm. This method takes into account both the time it takes to establish an optical link (acquisition time) and the bounded number of communication links, as each satellite has a fixed amount of optical communication modules installed. Based on a large number of simulations, we conclude that, although the underlying problem of bounded-degree-spanning-tree is NP-hard (even for static cases), the suggested ant-colony heuristic is able to compute cost-efficient solutions in semi-real-time.
BIM for Landscape Design Improving Climate Adaptation Planning: The Evaluation of Software Tools Based on the ISO 25010 Standard
Authors: Keibach Evelina , Shayesteh Homeira
Published: January 2022

This paper investigates the capabilities and limitations of different software tools simulating landscape design adaptability. The evaluation of tools is based on the ISO 25010 framework, which investigates software functionality, reliability, performance efficiency, usability, compatibility, and information quality. These quality characteristics of software are analysed during objective experiments where five software tools are used for a case study project at the conceptual design phase. These experiments reveal that the existing software tools for climate adaptation planning are focused on different aspects of climate adaptability, generating different types of information. Moreover, all tools deal with some limitations in terms of compatibility, performance efficiency, and functional operations. The ISO 25010 quality model provides a comprehensive framework to compare the capabilities of different software tools for climate adaptation planning. This paper is part of a wider study including an analysis of the needs of project stakeholders regarding climate adaptation software tools. However, this article focuses on technical capabilities of current climate adaptation software tools.
Modeling Joule Heating Effect on Thermal Efficiency of Photovoltaic Thermal (PVT) Collectors with Operation Mode Factor (OMF)
Authors: Yandri Erkata
Published: January 2022

The purpose of the present study is developing the operation mode factor (OMF) by remodeling the thermal efficiency model of a hybrid PVT collector during steady state. Joule heating occurs when the photovoltaic (PV) panel operates at a high current during maximum power point tracking (MPPT) on higher irradiation. Under these conditions, some electrical energy converts to thermal energy within the PV cells. Joule heating contributed to increasing the PVT thermal efficiency. The steps were to construct the OMF by remodeling the thermal efficiency involving the Joule heating effect and to validate the results using the model by comparing the simulation and experiment. The dimensionless OMF was responsible for changes in thermal efficiency for PVT-mode. The conductive heat transfer coefficient from the surface to the absorber was the most decisive component in the OMF. Heat removal factor and OMF might be interrelated at the mass flow rate by decreasing PV temperature to maintain Joule heating. The proposed model with OMF had explained PVT-mode and T-mode with the RMS value of less than 1%. This model complemented the results of the previous studies. The results may contribute from the initial design to the operational monitoring for thermal to electrical energy production.
New Form, New Material and Color Scheme, the Exposed Concrete Phenomenon—The Centennial Hall in Wrocław
Authors: Ilkosz Jerzy , Wójtowicz Ryszard , Urbanik Jadwiga
Published: January 2022

The aim of the article is to present the remarkable changes in architecture that took place in the 20th century. They can easily be called a revolution regarding the architectural form and the color scheme. Progress was being made through the development of reinforced concrete production methods. In the German Empire (Deutsches Kaiserreich), this material quickly found applications in more and more interesting solutions in architectural structures. In Wrocław (formerly Breslau), then located in the eastern German Empire, exceptional architectural works were realized before and after the First World War using new technology. In 1913, an unusual building was erected—the Centennial Hall, designed by Max Berg (inscribed on the UNESCO World Heritage List in 2006). Berg’s work was inspired by the works of both Hans Poelzig and Bruno Taut. On the one hand, it was a delight with the new material (the Upper Silesian Tower at the exhibition in Poznań, designed by H. Poelzig) and, on the other hand, with the colorful architecture of light and glass by B. Taut (a glass pavilion at the Werkbund exhibition in Cologne). Max Berg left the concrete in an almost “pure” form, not hiding the texture of the formwork under the plaster layer. However, stratigraphic studies of paint coatings and archival inquiries reveal a new face of this building. The research was carried out as part of the CMP (Conservation Management Plan—prepared by the authors of the article, among others) grant from The Getty Foundation Keeping It Modern program. According to the source materials, the architect intended to leave the exposed concrete outside of the building, while the interior was to be decorated with painting, stained glass, and sculpture. The stratigraphic tests showed that the external walls were covered with a translucent yellowish color coating. Thus, the Centennial Hall shows a different face of reinforced concrete architecture.
Melittin-Based Nano-Delivery Systems for Cancer Therapy
Authors: Wang Anqi , Zheng Yuan , Zhu Wanxin , Yang Liuxin , Yang Yang , Peng Jinliang
Published: January 2022

Melittin (MEL) is a 26-amino acid polypeptide with a variety of pharmacological and toxicological effects, which include strong surface activity on cell lipid membranes, hemolytic activity, and potential anti-tumor properties. However, the clinical application of melittin is restricted due to its severe hemolytic activity. Different nanocarrier systems have been developed to achieve stable loading, side effects shielding, and tumor-targeted delivery, such as liposomes, cationic polymers, lipodisks, etc. In addition, MEL can be modified on nano drugs as a non-selective cytolytic peptide to enhance cellular uptake and endosomal/lysosomal escape. In this review, we discuss recent advances in MEL’s nano-delivery systems and MEL-modified nano drug carriers for cancer therapy.
Erythropoietin Interacts with Specific S100 Proteins
Authors: Kazakov Alexey S. , Deryusheva Evgenia I. , Sokolov Andrey S. , Permyakova Maria E. , Litus Ekaterina A. , Rastrygina Victoria A. , Uversky Vladimir N. , Permyakov Eugene A. , Permyakov Sergei E.
Published: January 2022

Erythropoietin (EPO) is a clinically significant four-helical cytokine, exhibiting erythropoietic, cytoprotective, immunomodulatory, and cancer-promoting activities. Despite vast knowledge on its signaling pathways and physiological effects, extracellular factors regulating EPO activity remain underexplored. Here we show by surface plasmon resonance spectroscopy, that among eighteen members of Ca2+-binding proteins of the S100 protein family studied, only S100A2, S100A6 and S100P proteins specifically recognize EPO with equilibrium dissociation constants ranging from 81 nM to 0.5 µM. The interactions occur exclusively under calcium excess. Bioinformatics analysis showed that the EPO-S100 interactions could be relevant to progression of neoplastic diseases, including cancer, and other diseases. The detailed knowledge of distinct physiological effects of the EPO-S100 interactions could favor development of more efficient clinical implications of EPO. Summing up our data with previous findings, we conclude that S100 proteins are potentially able to directly affect functional activities of specific members of all families of four-helical cytokines, and cytokines of other structural superfamilies.
Zn2+ and Cu2+ Binding to the Extramembrane Loop of Zrt2, a Zinc Transporter of Candida albicans
Authors: Bellotti Denise , Miller Adriana , Rowińska-Żyrek Magdalena , Remelli Maurizio
Published: January 2022

Zrt2 is a zinc transporter of the ZIP family. It is predicted to be located in the plasma membrane and it is essential for Candida albicans zinc uptake and growth at acidic pH. Zrt2 from C. albicans is composed of 370 amino acids and contains eight putative transmembrane domains and an extra-membrane disordered loop, corresponding to the amino acid sequence 126–215. This protein region contains at least three possible metal binding motifs: HxHxHxxD (144–153), HxxHxxEHxD (181–193) and the Glu- and Asp- rich sequence DDEEEDxE (161–168). The corresponding model peptides, protected at their termini (Ac-GPHTHSHFGD-NH2, Ac-DDEEEDLE-NH2 and Ac-PSHFAHAQEHQDP-NH2), have been investigated in order to elucidate the thermodynamic and coordination properties of their Zn2+ and Cu2+ complexes, with the further aim to identify the most effective metal binding site among the three fragments. Furthermore, we extended the investigation to the peptides Ac-GPHTHAHFGD-NH2 and Ac-PAHFAHAQEHQDP-NH2, where serine residues have been substituted by alanines in order to check if the presence of a serine residue may favor the displacement of amidic protons by Cu2+. In the native Zrt2 protein, the Ac-GPHTHSHFGD-NH2 region of the Zrt2 loop has the highest metal binding affinity, showing that three alternated histidines separated by only one residue (-HxHxH-) bind Zn2+ and Cu2+ more strongly than the region in which three histidines are separated by two and three His residues (-HxxHxxxH- in Ac-PSHFAHAQEHQDP-NH2). All studied Zrt2 loop fragments have lower affinity towards Zn2+ than the zinc(II) binding site on the Zrt1 transporter; also, all three Zrt2 regions bind Zn2+ and Cu2+ with comparable affinity below pH 5 and, therefore, may equally contribute to the metal acquisition under the most acidic conditions in which the Zrt2 transporter is expressed.
Editorial for the Special Issue of Monitoring Anticoagulants
Authors: Amiral Jean
Published: January 2022

This Special Issue focuses on monitoring anticoagulant therapies and presents all the most recent updates introduced for laboratory practice, which benefit anticoagulated patients [...]
OXTR Gene DNA Methylation Levels Are Associated with Discounting Behavior with Untrustworthy Proposers
Authors: Anzani Stefano , Cannito Loreta , Bellia Fabio , Di Domenico Alberto , Dell’Osso Bernardo , Palumbo Riccardo , D’Addario Claudio
Published: January 2022

Individual differences in temporal and probabilistic discounting are associated with a wide range of life outcomes in literature. Traditional approaches have focused on impulsiveness and cognitive control skills, on goal-oriented personality traits as well as on the psychological perception of time. More recently, literature started to consider the role of social and contextual factors in discounting behavior. Between others, higher generalized trust in human beings and specific trust in people who will deliver the future/probabilistic rewards have been related to a stronger willingness to wait and to assume risk. Moreover, the tendency to trust others has been associated with the oxytocin receptor gene regulation that can be modified by life experiences. In this perspective, we hypothesized that differences in the tendency to wait and to take risks for a more desirable reward according to the proposer’s trustworthiness could be related to a different level of DNA methylation at the oxytocin receptor gene. Findings confirmed that participants are less willing to wait and to risk when the proposer is considered highly untrustworthy and revealed how higher oxytocin receptor gene DNA methylation is associated with a stronger effect due to the presence of an untrustworthy proposer. Limits and future directions are outlined.