bluuebunny/crossref_metadata_2025 huggingface dataset:
Mediating role of perceived social support between frailty and self-perceived burden in older patients with diabetes
Authors: Chen Ming-Zhu , Chen Xiao-Lei , Xu Qin , Cao Xiao-Dong , Wang Meng-Yu , Cao Rong
Published: October 2023

Objective To explore the mediating effects of perceived social support between frailty and self-perceived burden in older patients with diabetes, then provide theoretical basis for reducing the perceived burden of senile diabetic patients. Methods A total of 169 older diabetic patients who were hospitalized in the endocrinology department of a third-class hospital in Wuxi fromMay 2020 to July 2022 were investigated by convenience sampling method. Patients were investigated by the general information questionnaire, the Chinese version of the Tilburg Frailty Inventory (TFI), the Self-Feeling Burden Scale (SPBS), the Perceived Social Support Scale (PSSS).SPSS 22.0 was exployed for Pearson correlation analysis and multiple linear regression analysis, and we selected the Model 4 of SPSS PROCESS for mediating effect analysis. Results The SPBS of senile diabetes mellitus was positively correlated with TFI (P < 0.01), and negatively correlated with PSSS (P < 0.01).The results of Bootstrap test showed that the mediating effect of PSSS on the relationship between TFI and SPBS in older diabetic patients was 0.296(95%CI: 0.007, 0.066), and the mesomeric effect accounted for 17.3% of the total effect. Conclusion The debilitation of older patients with diabetes can reduce the burden of self-perception by perceived social support. Based on the improving perceived support, nurses should actively carry out comprehensive interventions,in order toreducing the self-perceived burden of older patients with diabetes.
Multivariate time Series Collaborative Compression for Monitoring Systems in Securing Cloud-based Digital Twin
Authors: Miao Zicong , Li Weize , Pan Xiaodong
Published: October 2023

With the booming of cloud-based digital twin systems, monitoring key performance indicators has become crucial for ensuring system security and reliability. Due to the massive amount of monitoring data generated, data compression is necessary to save data transmission bandwidth and storage space. Although the existing research has proposed compression methods for multivariate time series (MTS), it is still a challenge to guarantee the correlation between data when compressing the MTS. This paper proposes an MTS Collaborative Compression (MTSCC) method based on the two-step compression scheme. First, shape-based clustering is implemented to group the MTS. Afterward, the compressed sensing is optimized to achieve collaborative compression of grouped data. Based on a real-world MTS dataset, the experimental results show that the proposed MTSCC can effectively preserve the complex temporal correlation between indicators while achieving efficient data compression, and the root mean squared error of correlation between the reconstructed and original data is only 0.0489 in the case of 30% compression ratio. Besides, it is verified that using the reconstructed data in the production environment has almost the same performance as using the original data.
Exposure of cattle to tick-borne encephalitis virus in the historical endemic zone in north-eastern France
Authors: Mathews-Martin Laure , Gonzalez Gaëlle , Dheilly Nolwenn M. , Amaral-Moraes Rayane , Dumarest Marine , Helle Teheipuaura , Migne Camille , Caillot Christophe , Lacour Sandrine A. , Pérelle Sylvie , Beck Cécile , Metras Raphaëlle , Bournez Laure
Published: October 2023

Background: Tick-borne encephalitis (TBE) is a severe human neuroinfection caused by TBE virus (TBEV). TBEV is transmitted by tick bites and by the consumption of unpasteurized dairy products from infected asymptomatic ruminants. In France, several food-borne transmission events have been reported since 2020, raising the question of the level of exposure of domestic ungulates to TBEV. In this study, our objectives were (i) to estimate TBEV seroprevalence and quantify antibodies titres in cattle in the historical endemic area of TBEV in France using the micro virus neutralisation test (MNT) and (ii) to compare the performance of two veterinary cELISA kits with MNT for detecting anti-TBEV antibodies in cattle in various epidemiological contexts. A total of 344 cattle sera from four grid cells of 100 km² in Alsace-Lorraine (endemic region) and 84 from western France, assumed to be TBEV-free, were investigated.
Results: In Alsace-Lorraine, cattle were highly exposed to the virus with an overall estimated seroprevalence of 57.6% (95% CI: 52.1-62.8%, n=344), varying locally from 29.9% (95% CI: 21.0-40.0%) to 92.1% (95% CI: 84.5-96.8%). Seroprevalence did not increase with age, with one- to three-year-old cattle being as highly exposed as older ones, suggesting a short-life duration of antibodies. The proportion of sera with MNT titres lower than 1:40 per grid cell decreased with increased seroprevalence. Both cELISA kits showed high specificity (>90%) and low sensitivity (less than 78.1%) compared with MNT. Sensitivity was lower for sera with neutralising antibodies titres below 1:40, suggesting that sensitivity of these tests varied with local virus circulation intensity.
Conclusions: Our results highlight that screening strategy and serological tests should be carefully chosen according to the purpose of the serological study and with regard to the limitations of each method.
Efficacy and safety of re-administration of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) after EGFR-TKI-induced interstitial lung disease (CS-Lung-005)
Authors: Kanaji Nobuhiro , Ichihara Eiki , Tanaka Takaaki , Ninomiya Takashi , Kozuki Toshiyuki , Ishikawa Nobuhisa , Nishii Kazuya , Shoda Hiroyasu , Yamaguchi Kakuhiro , Kawakado Keita , Toyoda Yuko , Inoue Masaaki , Miyatake Nobuyuki , Watanabe Naoki , Inoue Takuya , Mizoguchi Hitoshi , Komori Yuta , Kojima Kazuki , Kadowaki Norimitsu
Published: October 2023

Purpose
This study investigated the safety and efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) re-administration after recovery from EGFR-TKI-induced interstitial lung disease (ILD).
Methods
This multicenter retrospective study collected data from consecutive advanced NSCLC patients who underwent EGFR-TKI re-administration after recovery from EGFR-TKI-induced ILD.
Results
Fifty-eight patients were registered. The grades of initial TKI-induced ILD were grade 1 to 4. TKIs used for re-administration were erlotinib for 15 patients, osimertinib for 15, gefitinib for 14, afatinib for 13 patients, and dacomitinib for 1 patient. ILD recurred in 13 patients (22.4%), comprising 3 patients with grade 1, 6 patients with grade 2, and 4 patients with grade 3. No significant associations were found between ILD recurrence and age, smoking history, performance status, time from initial ILD to TKI re-administration, or concomitant corticosteroid use. However, the incidence of ILD recurrence was high in cases of repeated use of gefitinib or erlotinib or first-time use of osimertinib at TKI re-administration. The ILD recurrence rate was lowest in patients treated with first-time use of gefitinib (8%) or erlotinib (8%), followed by patients treated with repeated use of osimertinib (9%). The response rate, median progression-free survival by TKI re-administration, and median overall survival were 55%, 9.6 months, and 84.8 months, respectively.
Conclusion
This study showed that EGFR-TKI re-administration is a feasible and effective treatment for patients who recovered from EGFR-TKI-induced ILD. Our results indicate that re-administration of EGFR-TKI is an important option for long-term prognosis after recovery from EGFR-TKI-induced ILD.
Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models
Authors: Kirsch David , Hendrickson Peter , Oristian Kristianne , Browne MaKenna , Lou Lixia , Ma Yan , Cardona Dianna , Linardic Corinne
Published: October 2023

CIC-DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and DUX4. Currently, there are no effective treatments and efforts to identify and translate better therapies are limited by the scarcity of patient tumor samples and cell lines. To address this limitation, we generated three genetically engineered mouse models of CDS (Ch7CDS, Ai9CDS, and TOPCDS). Remarkably, chimeric mice from all three conditional models developed spontaneous tumors and widespread metastasis in the absence of Cre-recombinase. The penetrance of spontaneous (Cre-independent) tumor formation was complete irrespective of bi-allelic CIC function and the distance between loxP sites. Characterization of primary and metastatic mouse tumors showed that they consistently expressed the CIC-DUX4 fusion protein as well as other downstream markers of the disease credentialing these models as CDS. In addition, tumor-derived cell lines were generated and ChIP-seq was preformed to map fusion-gene specific binding using an N-terminal HA epitope tag. These datasets, along with paired H3K27ac ChIP-seq maps, validate CIC-DUX4 as a neomorphic transcriptional activator. Moreover, they are consistent with a model where ETS family transcription factors are cooperative and redundant drivers of the core regulatory circuitry in CDS.
The effect of intraoperative intermittent pneumatic compression on deep venous thrombosis prophylaxis in patients undergoing craniotomy
Authors: Qi Xiang , Wang mengrui , Feng kang , Ma Yu , Zhang dan , Guo yidi , Fan Yujie , Jiao yubing , Zhang Xiao yu , wang baoguo , Shi zhonghua , Sun yongxing
Published: October 2023

Background: Postoperative deep venous thrombosis (DVT) is commonly observed in patients undergoing craniotomy and is associated with a high incidence of pulmonary embolism and poor clinical outcomes. Herein, we investigated the prophylactic effect of DVT of intraoperative intermittent pneumatic compression (IPC) in patients undergoing craniotomy.
Methods: A total of 516 patients who underwent elective craniotomy between December 2021 and December 2022 were enrolled in this study. Patients were randomly assigned to the intervention group (received intraoperative IPC) or control group (without IPC). Lower extremity ultrasound was performed on both legs before and after surgery (1h, 24h, and 7 days post-intervention). DVT was defined as the visualization of a thrombus within the vein lumen of the leg. Coagulation and platelet function were measured at the start and end of the craniotomy.
Results: A total of 504 patients (251 in the intervention group and 253 in the control group) completed the study. Among these patients, 20.4% (103/504) developed postoperative DVT within the first week after surgery, with 16.7% occurring within 24 hours. The incidence of postoperative DVT in the intervention group (9.6%, 24/251) was significantly lower than that in the control group (22.9%, 58/253, P<0.001). Intraoperative IPC reduced the risk of DVT by 64.6% (0.354, 95% CI, 0.223-0.564), P<0.001). There was no significant difference in coagulation and platelet function between the two groups (all P>0.05).
Conclusions: DVT may develop within 24 hours after the craniotomy. Intraoperative application of IPC reduces the incidence of postoperative DVT.
Metabonomics study on the effects of acupuncture and moxibustion in a rat knee osteoarthritis model
Authors: Li Yachen , Tan Qian , Liang Fangyuan , Li Jia , Cai Guowei , Li Jing
Published: October 2023

For elucidating effects of acupuncture and moxibustion on the metabolism of knee osteoarthritis (KOA) in rats, A method for metabolite analysis based on high throughput liquid chromatography-tandem mass spectrometry (LC-MS) was used to investigate overall changes in serum between groups. Rats were divided into four groups: control (C), model (M), KOA plus traditional acupuncture and moxibustion (T) and KOA plus syndrome differentiation acupuncture and moxibustion (S). The paw withdrawal threshold, open-field test and Hematoxylin and eosinstaining were applied to assess the transformations of knee hyperalgesia and histopathology. The serum metabolic fingerprints were obtained by using metabonomics. Orthogonal partial least squares-discriminant analysis was evaluated to highlight the differences and identify possible biomarkers. The changing trends of potential serum biomarkers and biological pathways of differential metabolites among different groups were analyzed. The results showed that acupuncture and moxibustion alleviate hyperalgesia and cartilage degeneration in KOA rats. A total of 11 metabolites were annotated between C and M. Among the 11 metabolites, the level of 5 metabolites were reversed in group S, including Glutathione, Ornithine, Alpha-dimorphecolic acid, Carnosine, Anserine, and group T only reversed the contents of 2 metabolites, including Aminoadipic acid and Carnosine. T versus M, beta-Alanine metabolism, Histidine metabolism, Tryptophan metabolism, mTOR signaling pathway, and Chagas disease were the affected pathways. Therefore, beta-Alanine metabolism, Histidine metabolism, Tryptophan metabolism were the main differential metabolic pathways after T treatment. In the comparison of the S and M groups, beta-Alanine metabolism, mTOR signaling pathway, D-arginine and D-ornithine metabolism, PPAR signaling pathway, and Chagas disease were the affected pathways. In conclusion, acupuncture and moxibustion can ameliorate the symptoms of KOA. Compared with traditional acupuncture and moxibustion, treatment based on syndrome differentiation obviously exerted an effect on KOA-induced metabolic alterations, which is related to the improvement of oxidative damage, inflammatory, cell autophagy, and energy metabolism.
Prevalence and factors associated with rota-virus diarrhea among children aged 3-24 months at a referral hospital in Uganda: A crossectional study
Authors: Laker Goretty , Nankunda Jolly , Melvis Bernis Maren , Kajoba Dickson , Nduwimana Martin , Kimera Joel , Odong Richard Justine , Edyedu Isaac
Published: October 2023

Introduction: Rota-virus, the most common cause of severe acute diarrhea in the world, has a significant morbidity and mortality in children under two years. The impact of rotavirus immunization in Uganda is not well established. This study aimed to determine the prevalence, severity of dehydration and factors associated with Rota-virus diarrhea among children aged 3 to 24 months at Fort Portal Regional Referral hospital.
Methods: This was a cross-sectional hospital-based study done between December 2022 and February 2023. Stool specimens were tested for rotavirus infection using rapid immunochromatographic assay test. Data was analysed using SPSS version 22 with logistic regression done to determine the factors.
Results: Out of 268 children with acute watery diarrhea, 133 (49.6%) were females, aged ≤ 12 months 177 (66.0%). Children who were positive for rotavirus infection were 42 (15.7%), majority of whom had some dehydration 28(66.7%). The factors that were significantly associated with Rota-virus diarrhea at multivariable level were; age less than 12 months (AOR = 8.866, CI = 1.549–50.738, P = 0.014), male gender (AOR = 0.083, CI = 0.019–0.356, P = 0.001), coming from a home with another person with diarrhea (AOR = 17.821, CI = 3.484–91.166, P = 0.001) or a home where the water source was a well (AOR = 50.170, CI = 4.401–71.966, P = 0.002).
Conclusion: The prevalence of Rota-virus diarrhea was three times less in the post Rota-virus vaccination period compared to pre-rota vaccination period. Majority of the participants with rotavirus diarrhea had some dehydration. There is need for provision of safe water sources to all homes. Surveillance to determine the cause of the non rota diarrhea should be done.
WITHDRAWN: Effect of unsaturated flow on the occurrence and movement of light nonaqueous phase fluids
Authors: Zhao Guizhang , Cheng Jiale , Li Leicheng , Liu Yu , Zhang Hongli , Li Hongliang , Zhang Hepeng
Published: October 2023

Contamination from light nonaqueous phase fluids (LNAPL) and their derivatives during mining, production, and transportation has become a concern. Scholars have extensively studied LNAPL contamination, but the role of water content variation on its migration process in the unsaturated zone has not been sufficiently researched. In this study, indoor simulated vertical, one-dimensional, multiphase flow soil column experiments were conducted on the sandy soil of the Zhengzhou reach of the Yellow River to analyze the effect of water content on the occurrence state and migration rate of LNAPL. The experimental results indicate: (1) The migration rate of LNAPL exhibits an L-shaped trend during subsurface imbibition and a nonlinear relationship with migration time, and the migration rate and migration time of surface infiltration have a linear growth relationship. (2) The adsorption rate of LNAPL is negatively correlated with water content and positively correlated with oil content in the homogeneous non-saturated state. As LNAPL moves from the aeration zone to the saturated zone, the relationship between oil content and water content is nonlinear. (3) When the water content of the test medium is below 14% and the oil content is below 11%, LNAPL appears in the aeration zone in a solid phase. As the water content increases, the adsorption rate of the oil phase gradually decreases and eventually reaches the oil saturation point. (4) When the water content of the medium exceeds 8%, over time, LNAPL will be subject to oil-water interfacial tension, and the rate of LNAPL movement first decreases and then increases, displaying nonlinear growth.
Evaluation of the Immunogenicity of a DNA Vaccine for Leishmania Major based on LACK antigen using Calcium Phosphate and Chitosan Adjuvants
Authors: Gharaei Abdolaziz , Rahdar Mahmoud , Jorjani Oghlniaz , Saberi Sedigheh , Beiromvand Molouk , Feiz-Haddad Mohammad Hossein
Published: November 2023

Leishmaniasis is a parasitic disease of global health concern, and an affordable and effective vaccine could be a valuable solution. The aim of this study was to evaluate the immunogenicity of a Leishmania major DNA vaccine based on LACK antigen using calcium phosphate and chitosan adjuvants nano particles. Seventy Balb/c female mice 4–6 weeks old and 20–22 g weight were selected and were divided into 5 groups [Each group 14 mice]. First Group received plasmid LACK vaccine [PCDN3 + LACK], second group received PCDN3 + LACK + Nano adjuvant phosphate Ca, third group received PCDN3 + LACK + Nano adjuvant chitosan, forth group received PBS as negative control and fifth group did not receive vaccine as positive control. The mice were vaccinated two times intramuscular injection with three weeks interval. The mice were challenged with wild type of Leishmania major promastigote via intra dermal injection into the basal of their tail three weeks after the last vaccination. Clinical sign and measuring the size of lesion were evaluated two times in every week. To assay immune system responses, IFN-gamma and IL4 were analysed using ELISA test after and before vaccination and challenging. The finding showed that PCDN3 + LACK + n anno chitosan, PCDN3 + LACK + nano calcium phosphate and PCDN3 + LACK [without adjuvant] groups had the highest increase in IFN- gamma titer and the greatest decrease of IL4 titer. The size of Leishmania lesion were decreased in vaccination groups and the best results were found in PCDN3 + LACK + nano chitosan at last week of challenging. Based on the results, vaccination with using of LACK antigen with nano calcium phosphate adjuvant and nano chitosan may be an effective approach for controlling cutaneous leishmaniosis in endemic region.
Correlation of gestational age and age at death in Sudden Infant Death Syndrome: another pointer to the role of critical developmental period?
Authors: Habich Malgorzata , Zielenkiewicz Piotr , Paczek Leszek , Szczesny Pawel
Published: October 2023

Background
Filiano and Kinney proposed a triple-risk model for the sudden infant death syndrome (SIDS) that involves the intersection of three risks: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control, and (3) an exogenous stressor(s). The primary evidence for the role of a critical developmental period in SIDS etiology is the peak of cases around the third month of life. Independently, several studies pointed to correlation between gestational age and age at death in SIDS, but used that to assess the SIDS risk for preterm infants, ignoring further ramifications.
Methods
We did a detailed analysis of CDC data spanning over two decades (1983-2011). We focused not only on the correlation between two age variables (gestational and age at death), but also on the possibility of misdiagnosis. Also, we attempted to account for potential biases in the data induced by the ICD-9/ICD-190 transition or the “Back to Sleep” campaign.
Results
The peak of deaths in the third month of life, that was the main argument for the role or critical development period, wasn’t unique to SIDS. However, we confirmed almost linear and negative correlation between gestational age and the week of death due to SIDS. This pattern (slope of correlation < 0 and significance of correlation p < 0.05) is characteristic for SIDS among all diseases analyzed in the study.
Conclusions
We interpret the results as the evidence of the role of the critical development period in SIDS etiology. Possibly more attention in the future research should be put to theories that are based on homeostatic control
Comparison of the Accuracy and Precision in Digital Scans for Implant-Supported Maxillary Hybrid Prosthesis: In Vitro Study
Authors: Sultanoğlu Elifnur Güzelce , Eroğlu Büşra Keleş
Published: October 2023

Background
This in vitro study aimed to assess and compare the accuracy and precision of six intraoral scanners (IOS) in the All-on-4 treatment concept.
Methods
An edentulous maxillary model was utilized, with four implants placed at 12, 15, 22, and 25 teeth positions, simulating the All-on-4 approach using resin acrylic. Following the placement of scanbodies, each of the six intraoral scanners (Primescan, Trios 3, Trios 4, Trios 5, Virtuo Vivo, Medit i 700) performed eight scans of the model. An industrial scanner was employed for the control group. Trueness evaluation involved aligning the data from the six dental scanners with the reference model. Precision analysis encompassed aligning the data from all six scanners within their respective groups. Data alignment and comparison were executed using the CloudCompare software (v2.11.3, General Public License of Telecom ParisTech, Paris, France). Statistical scrutiny encompassed the Shapiro-Wilk, Levene's, and Games-Howell tests.
Results
Among the scanners, Primescan exhibited the highest trueness (35,75±26,08 μm ), while the Medit i700 demonstrated superior precision (0,163 μm).
Conclusion
IOS can be used to make dental impressions within the All-on-4 concept. More comprehensive and clinical studies are needed on this subject.
An Experimental Study on Strength and Some Durability Characteristics of Concrete With 60% Replacement of Recycled Aggregate Concrete With Nanosilica
Authors: kuppili Prudvi , MURTY DSR
Published: October 2023

Scarcity of good natural materials have been playing a key role in present environmental consideration The present study is about the properties of concrete with natural crushed aggregate (NAC) recycled aggregate (RA). In this work, two sets of concrete grade. First set is (M20,M25,M30 & M35 with 100% M-sand & 100% crushed aggregate & 1.5% of Nano-silica by cement weight) i.e natural aggregate concrete (NAC), Second set (M20,M25,M30 &M35 with 100% Manufactured-sand & 60% recycled aggregate & 1.5% of Nano-silica by cement weight) i.e recycled aggregate concrete (RAC) with w/c ratio of (0.35–0.55) and PPC were taken. Mechanical & Durability properties of recycled coarse aggregate were studied with NAC & RAC and were tested at 3,7,28 days of curing. Durability aspects such as rapid chloride penetration & water permeability & Sorptivity and chloride attack are tested after 28days of curing,. this combination of recycled aggregate with natural aggregate. In this work, 0% of recycled aggregate concrete i.e (natural aggregate concrete) has shown good performance in mechanical properties when compared to 60% replacement of aggregates. 60% replacements shown good performance in durability properties. M-sand showed a good influence in contribution of strength properties.
Addressing healthcare practitioner genetic knowledge, attitude and practices in Gauteng Province, South Africa
Authors: Walters Sarah , Aldous Colleen , Malherbe Helen
Published: October 2023

Genetic testing and services are crucial in modern healthcare. Genetic testing is increasingly important in the diagnosis and treatment of more common diseases as well as rare diseases. Primary healthcare practitioners (HCPs), including general practitioners (GPs), are often the first contact point for patients seeking genetic information. However, many HCPs lack adequate genetic expertise to assist patients with genetic-related health concerns. Currently, no data is available on the genetic knowledge, attitudes, and behaviours of HCPs in the Gauteng province of South Africa. We aimed to investigate HCPs’ knowledge, attitude and behaviours towards genetics and genetic testing in the Gauteng province of South Africa. A tailored pre-validated questionnaire was administered online and in-person to targeted HCPs in the private healthcare sector in Gauteng, South Africa, to investigate genetic knowledge, behaviours and attitudes towards genetics and genetic testing. Of the 61 HCPs who responded (16.3% response), 95% were trained at South African medical schools. GPs, pathologists, physiotherapists, and specialists answered the questionnaire. Self-reported genetics knowledge was poor/very poor for 70% of respondents, making them ill-prepared to cope with the anticipated increasing demand for genetic information in primary healthcare. However, 93% displayed appropriate behaviour to genetic scenarios presented and showed positive attitudes towards providing and referring to, genetic services. Nevertheless, access to specific genetic information and resources was limited. Eighty-seven percent of respondents were interested in further genetic education. HCPs are interested in and expressed positive behaviours and attitudes towards genetics and genetic services, but their current knowledge is insufficient to cope with the growing demand.
Natural killer (NK) and HLA-C in in hepatitis C virus infected patient in Egypt during infection with Covid 19
Authors: Talat Ahmed Mohamed , Hassan Ali Mustafa Ali , Nakeeb Seham Mohamed Saied El , Mansour Safy Kabeel Ali
Published: November 2023

Hepatitis C virus (HCV) infection develops into chronic hepatitis in over two-thirds of acute infections. While current treatments with Sovaldi and ribavirin achieve HCV eradication in >95% of cases, no vaccine is available and re-infection can readily occur. Natural killer (NK) cells represent a key cellular component of the innate immune system, participating in early defence against infectious diseases, viruses, and cancers. When acute infection becomes chronic, however, NK cell function is altered. the NK immune response is a double-edged sword that is a significant component of the innate immune antiviral response, but persistent activation can drive tissue damage during chronic infection. Natural killer (NK) and lymphocytes with NK receptors (NKRs) is thought to play a key role in determining whether host immune responses to hepatitis C virus (HCV) infection result in viral clearance or disease progression. The aim of the present work was to Study of some immunological cells (cd 16, cd 56), genetic factors (HLA-C) in hepatitis C virus infected patients. A total number of 60 patients were included in this study. Their age ranged from 38-62 years old. The included patients were classified into 3 groups: group IA and IB (n=40) including cases with positive HCV antibodies (HCV-Ab), but negative real-time PCR for HCV after treatment with Sovaldi and Ribavirin, and they were considered as Responders, group IA Infected with covid 19, while group IB not Infected with covid 19. While group II (n=20) including patients with HCV infection ( HCV-Ab positive and real-time PCR for HCV is positive ) after treatment with Sovaldiand Ribavirin ( Non responders ) Considered as Non Responders. And group III ( n=60 ) healthy persons with matched age, sex and environmental status also included as controls.
Post-Discharge Care Practices, Challenges and Outcomes in Newborn Infants of Mothers with SARS-CoV-2 Infection: Insights from Public Hospitals
Authors: Patil Uday P. , Gupta Arpit , Heringman Kevin , Hickman Cherbrale , Paudel Umesh , Wachtel Elena V.
Published: November 2023

Background
The data regarding the care at home and outcomes in infants of mothers infected with SARS-CoV-2 continues to evolve. There is a paucity of studies beyond the immediate newborn period. Our research aims to improve the understanding in these areas by studying the newborn population discharged from public hospitals in several boroughs of New York City (NYC) through the first year of the Covid-19 pandemic.
Objective
To assess parental perspective and describe post-discharge care practices, patterns of healthcare utilization, challenges obtaining care, and outcomes in infants between 6 to 12 months of age born to mothers infected with SARS-CoV-2 at the time of delivery.
Methods
We conducted an IRB-approved multi-center retrospective cohort study of infants born to SARS-CoV-2 positive mothers at 5 NYC public hospitals between March and December of 2020. Clinical and demographic data were collected from electronic medical records. A phone interview of the caregivers using a standard questionnaire was conducted to collect data about care at home, healthcare utilization patterns, and challenges with access to healthcare.
Results
Our study cohort included 216 infants born to SARS-CoV-2 positive mothers with 16 (7.4%) mothers being symptomatic at discharge. Ten infants tested positive and 2 showed symptoms before discharge. Two hundred and seven (95.8%) infants were discharged home and 202 (94%) were discharged to their parents. 138 (66%) infants had at least 1 visit to the emergency room for various complaints where 2 were found to have Covid-19 with 1 needing hospitalization. 172 (79.6%) families responded to the phone interview. Most mothers (78%) cohabitated with their infant at home and 70.3% elected to breastfeed. However, only 56.3% of mothers reported using all the recommended infection prevention practices at home. More than half (57%) of the families reported financial hardship related to the pandemic. Although 46.2% of patients missed their in-person health maintenance visits, telemedicine was highly utilized for follow up with most being phone visits (70.3%). The majority of the infants (95.5%) remained up-to-date with their routine immunizations. Results are summarized in tables 1–3.
Conclusions
Our results suggest that infants born to SARS-CoV-2 infected mothers showed increased utilization of medical care and telemedicine between 6–12 months of age. Mothers reported low adherence to infection prevention practices at home however infants rarely showed clinically significant SARS-CoV-2 infection while maintaining high breastfeeding rates after discharge.
MSCA-YOLO: Accurate Detection of Railway Track Anomalies Using Multi-scale Features
Authors: Zhang Yan , Li Kefeng , Zhang Guangyuan , Wang Zhenfei , Zhu Zhenfang , Fu Chen , Jiang Guangyuan
Published: November 2023

With the escalating demands of modern railroad traffic, ensuring the integrity and safety of rails has become paramount. Railroad track fasteners and sleepers, integral components of the railroad system, can pose significant safety risks if they develop cracks or sustain damage. To detect such potential issues both timely and accurately, this paper introduces a crack detection method for railroad track fasteners and sleepers, enhancing the MSCA-YOLO mechanism of YoloV8. First, we integrate a detection head tailored for small targets into the model, amplifying the detection capabilities for minute cracks. A multi-scale MSCA attention mechanism is proposed, heightening the model's focus on the target and subsequently improving recognition accuracy. To validate the efficacy of the proposed method, we carried out a series of experiments using a self-curated real railroad track dataset. Experimental results demonstrate that, compared to YoloV8, our approach boosts detection accuracy by 4.5%, recall rate by 1.2%, and achieves a 0.9% increase in mAP. Our model presents an effective and practical solution for safety monitoring within railroad systems.
Do multifunctional organisms and Chlorella sp. microalgae benefit the production of Hymenaea courbaril L. seedlings?
Authors: Biazatti Renan Marré , Santos Silvia Correa , Santos Cleberton Correia , Pinheiro Bruno Lenhart , de Carvalho Rafael Lima , de Medeiros Elias Silva , Scalon Silvana de Paula Quintão , Torales Elissandra Pacito
Published: November 2023

The use of Azospirillum brasilense and Chlorella sp. has gained popularity in agriculture and forestry due to the benefits they offer to plants. These two biological solutions have demonstrated potential to improve the performance and sustainability of crops and forest species, opening new perspectives for agriculture and the recovery of degraded areas. Given the importance of establishing management strategies for seedling production and that information for forest essences is insufficient, the aim of this study was to evaluate the effect of intervals of Chlorella sp. microalgae application and inoculation with Azospirillum brasilense doses on the growth and quality of Hymenaea courbaril L. seedlings. The experiment was conducted in a randomized block experimental design, and treatments were arranged in a 5 x 4 factorial scheme, with four replicates, testing five A. brasilense doses: 0, 3, 6, 9 and 12 mL/plant and four intervals of Chlorella sp microalgae application: single application and every 7, 14 and 21 after transplanting (DAT), for 120 days. Growth and photosynthetic parameters were evaluated. Inoculation with 6 and 9 mL of Azospirillum brasiliense, regardless of Chlorella sp. microalgae application favored the growth of H. courbaril seedlings. Chlorella sp. microalgae application at intervals of 14 and 21 days favored the responses of seedlings inoculated with Azospirillum brasilenses. The association between Azospirillum brasiliense and Chlorella sp. promoted gains in seedling production and quality.
IMITATIO SPECIEI GERMANICAE: INOCULTURAL INNOVATIONS IN THE FORM OF THE AESTII AND PRUSSIANS I–VI
Authors: КУЛАКОВ В.И.
Published: October 2023

В предлагаемой главе при помощи письменных и археологических источников выявлен интереснейший исторический феномен. Часть западных балтов, непосредственно граничивших с восточными германцами, с I-II в. по минимум VII в. стремилась к подражанию деталям убора и, очевидно, внешнему виду германцев, причём — западных. Это стремление было основано на высоком авторитете, который был достигнут западной частью германских племён среди остального населения Barbaricum. Сами же германцы ко времени крушения Западной Римской империи всё больше старались походить на носителей провинциально-римской традиции. Даже первое готское государство в Италии, основанное в 476 г. Одоакром, формально считалось частью Восточной Римской империи. Упомянутые имитационные тенденции в сознании германцев позднеримского времени привели к возникновению лозунга Imitatio Imperii Romanorum, актуального при формировании основ будущей Священной Римской империи германской нации.

In the proposed chapter, with the help of written and archaeological sources, an interesting historical phenomenon is revealed. Part of the western Balts, directly bordering on the eastern Germans, from the 1st-2nd centuries. at least the 7th century strove to imitate the details of the dress and, obviously, the appearance of the Germans, moreover, the Western ones. This desire was based on the high prestige that was achieved by the western part of the Germanic tribes among the rest of the Barbaricum population. By the time of the collapse of the Western Roman Empire, the Germans themselves were increasingly trying to resemble the bearers of the provincial Roman tradition. Even the first Gothic state in Italy, founded in 476 by Odoacer, was formally considered part of the Eastern Roman Empire. The aforementioned imitative tendencies in the minds of the late Roman Germans led to the emergence of the slogan Imitatio Imperii Romanorum, relevant in the formation of the foundations of the future Holy Roman Empire of the German nation.
INTERPRETATION OF THE ROYAL PERIOD ROMAN HISTORY IN CHRISTIAN APOLOGIES
Authors: ХОРЬКОВА И.В.
Published: October 2023

В главе речь идет об изложении римской истории царского периода в сочинениях христианских апологетов. В качестве критерия отбора материала избран этнолингвистический принцип, поэтому в статье рассматриваются только латиноязычные авторы. Помимо латинского языка апологетов этой группы объединяет общий ментальный субстрат, полемические приемы и общие источники информации. В статье анализируются различные примеры интерпретации латинскими апологетами событий древнейшей римской истории с целью определения ее общих черт и задач. В результате исследования делается вывод, что основной задачей христианских авторов при рассмотрении ранней римской истории является дискредитация римской старины. При этом апологетами используется тенденциозный отбор материала, рациональная критика событий, негативная морально-нравственная и правовая оценка.

This chapter deals with the presentation of the Roman history of the royal period in the writings of Christian apologists. The ethnolinguistic principle was chosen as a criterion for the selection of material, therefore, only Latin-speaking authors are considered in the article. In addition to the Latin language, apologists of this group combine a common mental substrate, polemical techniques and common sources of information. The article analyzes various examples of Latin apologists' interpretation of the events of ancient Roman history in order to determine its common features and challenges. As a result of the study, it is concluded that the main task of Christian authors when considering early Roman history is to discredit Roman antiquity. Apologists use tendentious selection of material, rational criticism of events, negative moral and legal assessment.
«BARBARIAN ANTIQUITY» OR «DECREPIT MODERNITY»? FORMATION OF THE «ADVANCEMENT OF LEARNING» CONCEPT IN THE AGE OF QUEEN ELIZABETH AND JACOB I
Authors: ШПАК Г.В.
Published: October 2023

На протяжении XX в. исследователи использовали разнообразные подходы к изучению истории знания, зачастую выстраивая прямую, ведущую от невежественного прошлого к прогрессивной современности. Даже авторы, призывающие к осторожности, в силу риторических особенностей текста представляли развитие науки как поступательный процесс накопления истин, не учитывая их конструктивный характер. Концепт «Научная революция», используемый в качестве исторической рамки в широком смысле подразумевал коренную трансформацию рецептивно-репрезентативных практик, произошедших в границах 1543 и 1687 гг. Как хронологические, так и территориальные границы этого концепта не могут быть четко обозначены в связи с его конструктивной природой. В силу этого формируется представление о разрыве между знанием прошлого и всем, что было до «Научной революции». В Англии конца XVI – первой четверти XVII в. происходила трансформация восприятия времени, которая шла параллельно с так называемой «борьбой древних и новых», когда современные практики описания реальности были объявлены более релевантными, чем практики прошлого. Это привело к тому, что уже в XVIII в. французские просветители начали говорить о революции, произошедшей в познании, а все что относилось к предшествующему времени было объявлено невежественным и варварским.

Throughout the XX century researchers used a variety of approaches to the study of the history of knowledge, often describing a straight line leading from the ignorant past to the progressive modernity. Even the authors calling for caution due to the rhetorical features of the text presented the development of science as a progressive process of accumulating truths, often not taking into account the constructive nature of knowledge. The concept of “Scientific Revolution”, used as a historical framework in a broad sense, implied a radical transformation of the receptive-representational practices that occurred within the boundaries of 1543 and 1687. Both chronological and territorial boundaries of this concept cannot be clearly defined due to its constructive nature. Because of this, the idea of a gap between knowledge of the past and everything that was before the “Scientific Revolution” appeared. In England at the end of the 16th century and the first quarter of the 17th century, a transformation in the perception of time took place, which went in parallel with the so-called “Quarrel of the Ancients and the Moderns”, when modern practices of describing reality were declared more relevant than those of the past. This led to the fact that already in the 18th century, the French enlighteners began to talk about the revolution that had taken place in knowledge, and everything that related to the previous time was declared ignorant and barbaric.
HISTORICAL MODEL OF VERBAL BARBARITY
Authors: БУДАНОВА В.П.
Published: October 2023

На основе исследования письменной традиции рубежа Античности и Средневековья представлена историко-лингвистическая характеристика языковых особенностей дискурса варварства. В качестве концептуальной основы используются модели вербального варварства. Концепт «вербальное варварство» впервые применяется для обозначения словесного проявления побуждения к злонамеренному действию, содержащего угрозу, с целью спровоцировать агрессию, физическое насилие, причинить ущерб, психологическую боль и ментальные страдания. Анализируется лексико-семантическая целеориентированность образа и сценария вербального поведения варвара в «Res gestae» Аммиана Марцеллина и «Getica» Иордана. Представлены описательные, экспрессивные, оценочные и орективные функциональные особенности словоупотребления с пейоративной семантикой. Автор приходит к заключению, что в системе позднеантичного и раннесредневекового дискурса варварства вербальная характеристика варвара и лексемы злословия отличались эмоционально-психологическим императивным воздействием, выявляя взаимосвязь физической и теневой стороны злонамеренного действия.

Based on the study of the written tradition of the turn of Antiquity and the Middle Ages, the historical and linguistic characteristics of the linguistic features of the discourse of barbarism are presented. Models of verbal barbarism are used as a conceptual basis. The concept of «verbal barbarism» is used for the first time to denote the verbal manifestation of an incentive to malicious action containing a threat in order to provoke aggression, physical violence, cause damage, psychological pain and mental suffering. The lexico-semantic goal orientation of the image and scenario of the verbal behavior of the barbarian in the «Res gestae» by Ammian Marcellin and «Getica» by Jordan is analyzed. Descriptive, expressive, evaluative and indicative functional features of word usage with pejorative semantics are presented. The author comes to the conclusion that in the system of late Antique and early medieval discourse of barbarism, the verbal characteristics of the barbarian and the lexemes of slander differed in emotional and psychological imperative effects, revealing the relationship between the physical and shadow side of malicious action.
ANÁLISE DAS RELAÇÕES ENTRE AS CARACTERÍSTICAS ORGANIZACIONAIS E O USO DE INDICADORES DE DESEMPENHO NO ÂMBITO DE HOSPITAIS PÚBLICOS VINCULADOS À EBSERH
Authors: Santiago da Silva Ivan
Published: October 2023

Este estudo teve como objetivo analisar as relações entre as características organizacionais e o uso de indicadores de desempenho no âmbito de hospitais públicos federais vinculados à Empresa Brasileira de Serviços Hospitalares – EBSERH. Foi utilizada a estatística descritiva, e o teste estatístico de Coeficiente de Correlação de Postos de Spearman, adotando-se o nível de significância de p igual ou inferior a 0,05. Os resultados mostraram uma baixa frequência no uso dos indicadores de desempenho e de estrutura. Entre os dados coletados a utilização plena ficou com o grupo de indicadores de instalações, correspondendo 100% de utilização entre os hospitais da rede EBSERH. A região que apresentou o maior uso de indicadores foi a Nordeste com uma média de 21,35 indicadores, e a menor foi a Sudeste com uma média de 17,75 indicadores. Não foi identificada nenhuma correlação significativa no teste de correlação de Spearman. Concluímos que a utilização de indicadores por parte dos hospitais universitários geridos pela EBSERH mostrou-se comprometida sua acessibilidade e transparência, e está distante do que seria o ideal para subsidiar os gestores na tomada de decisão, no acompanhamento e revisão de suas metas, e na reavaliação de seu planejamento estratégico.
ESTUDO BIBLIOMÉTRICO SOBRE INDICADORES DE DESEMPENHO NA GESTÃO HOSPITALAR
Authors: Ananine Paiva Erika , M. da Silva Fabrizio
Published: October 2023

Objetivo: apresentar um estudo bibliométrico sobre Indicadores de Desempenho na gestão hospitalar. Método: Foi utilizada uma revisão bibliométrica. Optou-se pela utilização da base de dados Web of Science para a coleta de dados e os softwares “Bibliometrix” e “StudioR” para a análise dos dados. A estratégia metodológica para buscar material científico foi realizada da seguinte maneira: foram utilizadas palavras chaves, tais como: “performance indicator”, “hospital management” e “performance” na busca científica. No total, obtivemos um número de 296 documentos. Não foi empregado corte temporal na amostragem, desse modo, a pesquisa abrangeu materiais de 1945, data de fundação da base Web of Science, até 2021, quando foi feito o levantamento. Foram analisados, no primeiro momento, dados sobre os autores, periódicos e documentos. No segundo momento, a análise abordou a estrutura conceitual e intelectual. Fundamentação teórica: foi apresentado uma evolução temporal acerca das publicações científicas sobre indicadores de desempenho na gestão hospitalar com diferentes focos na organização hospitalar. Resultado: Entre os principais resultados encontrados na análise, foi possível constatar que a amostra teve início em 1988, porém o tema começou a ganhar grande volume de publicações a partir de 2005, tendo maior número de documentos publicados em 2020, chegando a 43. Os autores em destaque são: Amos D; Au-Yong CP; Liu HC e Musa ZN, com 4 documentos cada. A área com maior quantidade de publicações Health Care Sciences Services juntamente com Health Policy Services com 56 documentos cada. O principal periódico é a Revista International Journal for quality in Health Care com 8 documentos. As palavras mais citadas são: Hospitals / hospital (34), Performance indicators e quality indicators (17), Performance; performance measurement (16). Por fim, não menos importante, quando analisada a estrutura conceitual desses materiais, é possível identificar dois grupos bem significativos, com grande quantidade de publicações: Quality indicators e Performance Management. A partir da análise da estrutura intelectual, feita por meio da Cocitação, foi possível identificar cinco grupos, com foco na gestão hospitalar e sistema de medição de desempenho, (Kaplan) voltados para qualidade na prestação de serviços, (Donabedian), na qualidade e segurança do paciente, (Shortell SM; Berwick, SM), relacionados a Medicina geral e interna, (Peterson, ED e Fonarow, GC), e por fim, um grupo que tem relação direta e características nas quatros áreas discorridas anteriormente, destaque para o autor (Ruter).

Palavras chaves: Indicadores de desempenho; Gestão hospitalar; Performance