bluuebunny/crossref_metadata_2025 huggingface dataset:
Histopathological Spectrum of Upper Gastrointestinal Endoscopic Biopsies in a Tertiary care centre
Authors: M.L Anjana , Yevoor Kavitha
Published: July 2021

Background: Upper GI endoscopy is an established procedure for investigating a wide range of upper GI conditions especially inflammatory and malignant diseases of stomach and esophagus. A good correlation in diagnosis can be achieved by complementing endoscopic findings with histopathology of biopsy specimens.

Methods: Both retrospective and prospective study of upper GI endoscopic biopsy was carried out at department of pathology, KIMS, Hubli during January 2016 to December 2018. Samples were received in 10% formalin; routine processing was followed with H & E staining. Special stain like Giemsa was done for detection of H. Pylori. 396 endoscopic mucosal biopsies were analyzed and evaluated.

Result: Out of 396 cases, 250 cases were esophageal biopsies, 104 cases were gastric biopsies & 42 cases were duodenal biopsies. The male: female ratio was 1:9:1. The highest number of cases was seen between 61 to 70 years. Dyspepsia was the common symptom seen in 61.3%. The most common lesions encountered in the esophagus were carcinomas (67%) followed by esophagitis (16%). The commonly encountered gastric lesion was chronic gastritis in 54.8% with H. pylori gastritis being positive in 38.18%. Among the duodenal biopsies, non-neoplastic lesions were most common (59.5%) followed by neoplastic lesions (26%).

Conclusion: Upper GI endoscopy is an effective and appropriate preliminary investigation to assess patients with dysphagia, dyspepsia, vomiting. Endoscopy without biopsy is incomplete and that the combination of methods offers a strong diagnostic tool for better patient care.
Technology Integration of the In-Service EFL Teachers: A Study at a Teacher Profession Education Program
Authors: Tuzahra Fatimah , Sofendi Sofendi , Vianty Machdalena
Published: July 2021

Utilizing technology in the classroom characterizes the 21st century teachers. Therefore, teachers are demanded to be able to use technology in pedagogical practices in order to fulfill their students’ needs facing rapidly digitalized life. This study was designed to investigate the perceptions of a group of in-service English as Foreign Language (EFL) teachers who studied at a Teacher Profession Education program at a state university, concerning the application of technology within challenges they faced during their study. This study used qualitative research with narrative approach as a strategy of inquiry. The data were obtained by using a semi-structure interview with the in-service teachers and documentation. The data were analyzed using thematic analysis. The results of the study showed that the participants generally perceived positively the technology integration taught by their university instructors during their study time at the Teacher Profession Education program although there was a negative response when they were firstly introduced with the technology. It might have been caused by their lack of technological knowledge. The result also revealed that the participants found it challenging when it came to the use of novel technology as introduced and applied by their university instructors. In addition, their own integration of technology during their Teaching Practice was a challenge due to the students’ low motivation to engage in the online learning activity which was the mode of learning. The findings of this study suggest that teachers need to advance their skills and knowledge to utilize technology in supporting their pedagogical practices.
PENSAMENTO COMPUTACIONAL: INSTRUMENTOS PARA AVALIAR E CLASSIFICAR A ALFABETIZAÇÃO EM CÓDIGO
Authors: Cordenonzi Walkiria Helena , Del Pino José Claudio
Published: July 2021

O objetivo deste artigo é apresentar um conjunto de instrumentos para avaliar o desenvolvimento do Pensamento Computacional em indivíduos adultos. Estes foram ancorados na teoria da aprendizagem significativa (Ausubel) e na Andragogia (Knowles). A proposta consiste em apresentar um MRPC (Modelo de Referência do Pensamento Computacional) e um método de avaliação (baseado em avaliações objetivas e subjetivas). Para sua validação foi desenvolvido um constructo andragógico e como resultado da aplicação deste método, é possível classificar os participantes em Alfabetizado em Código (ACod), Pensador Computacional Desplugado(PCD) ou nenhum dos anteriores. Esse método foi aplicado em dois cursos binacional - no qual brasileiros e uruguaios compartilham o mesmo espaço de aprendizagem. Por meio de estudos de caso e da análise quali-quantitativa dos resultados, obteve-se, do total da amostra, 66,6% dos sujeitos foram classificados como ACod e 14% como PCD. Com isso evidencia-se a corretude dos instrumentos propostos e sua aplicabilidade.
RECURSOS TECNOLÓGICOS EM MUSEUS DE CIÊNCIAS: TENDÊNCIAS EM ESTUDOS BRASILEIROS
Authors: Costa Pedro Miguel Marques da , Rocha Marcelo
Published: July 2021

Os recursos tecnológicos estão cada vez mais presentes no cotidiano das pessoas e nas mais diversas situações, como por exemplo nos museus de ciências. Com o objetivo de investigar se a tecnologia vem sendo utilizada em museus, analisou-se a produção acadêmica a partir de artigos publicados em revistas de Qualis A1, na área de ensino, no período de 2015 a 2019. Foram analisadas 13 revistas e identificados 23 artigos com base nos descritores: museus, tecnologia e tecnologia em museus. Posteriormente, estes artigos foram agrupados por categorias à luz da análise de conteúdo. Os resultados evidenciaram um decréscimo de publicações sobre museus e um discreto, mas não significativo, aumento de publicações na área da tecnologia. Acerca do uso da tecnologia em museus não foi encontrada nenhuma publicação. Assim, o presente este estudo traz importantes desdobramentos no sentido de sinalizar a carência de trabalhos que investigam como a tecnologia tem sido incorporada em museus, visto que se trata de um tema atual e de grande impacto social.
THE PROBLEM OF THE COMBINED USE OF FILTRATION THEORY AND MACHINE LEARNING ELEMENTS FOR SOLVING THE INVERSE PROBLEM OF RESTORING THE HYDRAULIC CONDUCTIVITY OF AN OIL FIELD
Authors: KOSYAKOV Vitaly P. , LEGOSTAEV Dmitry Yu. , Musakaev Emil N.
Published: July 2021

This article presents the methodology involving the combined use of machine learning elements and a physically meaningful filtration model. The authors propose using a network of radial basis functions for solving the problem of restoring hydraulic conductivity in the interwell space for an oil field. The advantage of the proposed approach in comparison with classical interpolation methods as applied to the problems of reconstructing the filtration-capacitive properties of the interwell space is shown. The paper considers an algorithm for the interaction of machine learning methods, a filtration model, a mechanism for separating input data, a form of a general objective function, which includes physical and expert constraints. The research was carried out on the example of a symmetrical element of an oil field. The proposed procedure for finding a solution includes solving a direct and an adjoint problem.
IMPACT OF WATER AND CO2 ON THE MECHANICAL PROPERTIES OF LOW PERMEABLE ROCKS
Authors: KISLITSYN Anatolii A. , Lipatov Nikita V.
Published: July 2021

This article features experiments on triaxial compression of low-permeable dolomite samples with different confining pressures (2-20 MPa), different pore fluids (dry air, water, CO2), and different temperatures (25-150 °C). The authors have studied the effect of confining pressure, pore fluid and temperature on the strength properties of the studied samples. The results show an increase in the strength with grwoing confining pressure. When the confining pressure increases from 2 to 20 MPa, the compressive strength increases from 86 to 370 MPa. Temperature has a significant effect on rock strength under low confining pressure conditions. With the increasing confining pressure reaching 15 MPa, increasing temperature has little effect on the strength of dolomite samples. Under an effective confining pressure of 5 MPa, the temperature weakening occurs on the dolomite specimens when the temperature exceeds 90 °C. During compression, liquid diffusion occurs in the specimens. Higher water viscosity can cause a temporary decrease in effective confining pressure, which can increase the strength of the rock. More prominent fractures are observed in the samples, and more fluid is injected under CO2 injection conditions, which may be useful for increasing the permeability of the geothermal reservoir. Two groups of experiments have been performed on the samples in this study: the first group of experiments investigated the effect of confining pressure on the fracture stress of core samples, without pore fluid injection; the second group of experiments investigated the effect of water or CO2 and temperature on the mechanical properties of core samples.
MODELING THE SYNTHESIS OF TAKAGI — SUGENO — KANG FUZZY CONTROLLERS IN SOME CONTROL SYSTEMS
Authors: Kulikova Irina V.
Published: July 2021

Modern challenges in a post-industrial society require further development of management systems for complex technical and technological phenomena and processes. Effective control of an object is possible if a controller, or a fuzzy controller, correctly generates the required control action. Recently, fuzzy controllers have been very popular. Fuzzy logical statements in this case help considering various nonlinear relationships. The synthesis of the fuzzy controller parameters allows for more efficient operation of the control system. A possible option for obtaining the best set of parameters for a fuzzy controller is the use of genetic algorithms for its synthesis. The use of genetic algorithms for the fuzzy controllers synthesis can lead to the fact that the elements of its parameters array will change in such a way that an incorrect value of one or more elements will occur. This situation leads to impossibility of composing membership functions for the terms of the variables of the fuzzy controller. Incorrect value formation is excluded by constructing a limited functional dependency.
This paper proposes a mathematical model of the parameters of the term-set of variables of a fuzzy controller of the Takagi — Sugeno — Kang type of the zero and first orders. The authors disclose the content of the conditions and conclusions of the rule base for the fuzzy controller of the above type.
As a result of the simulation, some operations of the genetic algorithm are implemented using a random number generator. Graphical models of the membership functions of the input variables of the fuzzy controller of the type under consideration clearly illustrate the occurrence of all parameters in their range of possible values. A description of the control system operation with two control parameters and one control action at the specified values of the control parameters is presented.
THE ANALYSIS OF THE BINARY HOMOGENEOUS SOLUTION FILM BEHAVIOR UNDER THERMAL ACTION
Authors: BORODINA Kseniia A.
Published: July 2021

Studying the processes occurring in liquid films under thermal influence allows improving a variety of technological systems, since a thin layer aids in providing a high intensity of heat and mass transfer and a significant surface of phase contact with a minimum liquid consumption. Many Russian and international works wrote about theoretical and experimental studies of film flows, though paid insufficient attention to the study of the behavior of films of a binary homogeneous solution. This article studies the behavior of a thin liquid film containing a volatile component during local heating of a solid horizontal substrate. The presented calculations were performed for an aqueous solution of isopropanol. The author describes the formation of a specific surface shape, which is formed with a sufficient increase in the substrate temperature and the initial film thickness — the so-called “liquid drop”, separated from the main volume of the liquid by a thin extended layer, which is explained by the sequential occurrence of thermal and concentration-capillary flows. The results show a significant influence of the Laplace pressure jump on the character of the entire process. In addition, the cooling of the substrate leads to multidirectional flows, but in the opposite directions. The analysis of the functions of the temperature of the film free surface, the volatile component concentration in the solution, and the vapor density over the free surface at different times is carried out. The velocity field in liquid and gas during the evolution of thermocapillary and concentration-capillary flows is illustrated.
EXPERIMENTAL STUDY OF HEAT EXCHANGE FROM A STEAM-GAS MIXTURE DURING HEAT TRANSFER THROUGH A RIBBED SURFACE
Authors: Zinurov Vadim E. , Dmitriev Andrey V. , Sharipov Ilnar I. , Galimova Alsu R.
Published: July 2021

This article deals with the problem of heat energy transfer from a steam-gas mixture with a constant temperature of 220 °C. An experimental study of the transfer of heat energy from a steam-gas mixture by a recuperative heat exchanger with a ribbed surface at the industrial enterprise “PULP Invest”, located at the production site of the industrial park Technopolis “Khimgrad” in Kazan, is presented. The design of a heat exchanger with a ribbed surface is described. The finned surface of the recuperative heat exchanger allowed intensifying the transfer of heat flow, due to the appearance of turbulent vortices of the vapor-gas medium when it moves between the transversely arranged fins. For a heated heat carrier, water was used, which in the future is planned to be used for technological and economic needs. This paper presents the experimental method and measuring instruments. During the experiments, the initial temperature of the cold coolant (water) varied from 28.8 to 31.9 °C. The series of experiments included 7 experiments with a different volume flow of water from 60 to 120 liters/hour. The initial volume flow rate was 60 l/h, the flow rate change step was 10 l/h. The results of the studies showed that the time of the output of the studied parameters: temperature head, heat flow and heat transfer coefficient to the stationary mode was 265 s. When entering the stationary mode with a volume flow rate of cold coolant in the range from 60 to 120 l/h, the temperature head varied from 32.2 to 63 °C, the heat flow varied from 4.1 to 4.5 kW, the heat transfer coefficient varied in the range of 24.4-27.9 W/(m2 · K). The obtained results allowed establishing that the heat transfer coefficient is inversely proportional to the thermal resistance of the vapor-gas phase.
AN ANALYTICAL MODEL OF A NON-STATIONARY TEMPERATURE FIELD IN A RESERVOIR WITH A HYDRAULIC FRACTURING
Authors: SHARAFUTDINOV Ramil F. , Davletshin Filyus F.
Published: July 2021

At the present stage of development of the oil and gas industry, considerable attention is paid to methods of increasing oil recovery of productive reservoirs. One of the most popular methods of intensifying oil production today is hydraulic fracturing. The efficiency and success of hydraulic fracturing largely depends on the parameters of the formed fracture; in this regard, the development of methods for evaluating the parameters of hydraulic fracturing fractures is an urgent task. Non-stationary thermometry is a promising area for monitoring the quality of hydraulic fracturing. To date, thermometry is used to localize the locations of multiple fractures in horizontal wells. In this paper, we study the application of non-stationary thermometry for estimating the parameters of a vertical hydraulic fracturing fracture.
An analytical model of non-isothermal single-phase fluid filtration in a reservoir with a vertical fracture is developed. To calculate the temperature field in the formation and the fracture, the convective heat transfer equation is used, taking into account the thermodynamic effects (Joule — Thomson and adibatic), for the fracture, the heat and mass transfer between the fracture and the formation area is also taken into account. To assess the correctness of the model, the analytical solution is compared with the results of numerical modeling in the Ansys Fluent software package.
The nonstationary temperature field is calculated for the constant sampling mode. It is established that at the initial moment of time after the well start-up, a negative temperature anomaly is formed due to the adiabatic effect, the value of which increases with a decrease in the fracture width. Over time, the temperature of the fluid flowing into the well increases due to the Joule — Thomson effect, and the value of the positive temperature anomaly increases as the width and permeability of the fracture decreases due to an increase in the pressure gradient in it.
The developed analytical model can be used to solve inverse problems for estimating hydraulic fracturing parameters based on non-stationary temperature measurements in the wellbore of producing wells.
Interleukin-1A May Illuminate Differential Effects of the Retinal Artery Caliber in HIV Patients
Authors: Edwar Lukman , Ariyanto Ibnu Agus , Tanudjaja Selita Agnes , Sitompul Ratna , Lee Silvia , Price Patricia
Published: July 2021

Background: Retinal artery caliber (RAC) is narrower in human immunodeficiency virus (HIV)-infected patients beginning antiretroviral therapy (ART). We aimed to assess associations between variations in genes encoding inflammatory mediators and natural killer receptors and retinal artery caliber (RAC) in HIV patients beginning ART.Materials and Methods: Seventy-nine HIV positive patients beginning ART with less than 200 cluster of differentiation (CD) 4 T-cells/μL were recruited. Examinations were performed before ART (V0) and at months 3, 6 and 12 (V3, V6, V12). The study was approved by ethics committees and informed consent was obtained from each subject.Results: Right and left RAC of the HIV patients were narrower than healthy controls (p=0.016 for right RAC) and narrowed further on ART, but demographic associations with the right and left RAC were not identical. Here we show that polymorphisms in genes encoding NK receptors or TNF activity had no significant impact, but right RAC was associated with carriage of allele 2 at IL1A+4845 (p=0.037 after 12 months on ART).Conclusion: Overall the paradoxical reduction in the RAC in HIV patients responding to ART was not modified by genotypes known to affect NK cell function or TNF responses, but IL1A genotype may modify the decline in the right RAC.Keywords: anti-retroviral therapy, CMV, HIV, IL1A, retinal artery caliber
Cancer Genetics and Epigenetics in Cancer Risk Assesment
Authors: Meiliana Anna , Dewi Nurrani Mustika , Wijaya Andi
Published: July 2021

Compared to the normal tissues, cancer cells tend to have higher proliferation rate and often lost their ability to undergo apoptosis. In addition, cancer cells can separate themselves from their original tissue thus causing metastasis in other part of body. While undergoing program cell death, disordered cellular programming can happen. The main causes of this cellular programming anomaly are epigenetic and genetic alterations, which have been known as two separate mechanisms in carcinogenetic. A recent outcome of whole exome sequencing of thousands of human cancers has been the unexpected discovery of many inactivating mutations in genes that control the epigenome. These mutations have the potential to disturb the DNA methylation patterns, histone modifications, and nucleosome positioning, hence, the causing gene expression alternation. Genetic alteration of the epigenome therefore contributes to cancer just as epigenetic process can cause point mutations and disable DNA repair functions. Epigenetic mechanisms changes could cause genetic mutations, and genetic mutations in epigenetic regulators could cause epigenome changes. Knowing that epigenome play a major role in the hierarchy of gene control mechanisms suggests that mutations might have impact on multiple pathways related to cancer phenotype. This pinpoint the fact that recently, the way the genes are organized and controlled are suggested to be a relevant factor for human carcinogenesis.Keywords: cancer genetic, cancer epigenetic, oncogens, tumor suppressor genes, driver mutation, passenger mutation
Endometrial Cancer: Genetic, Metabolic Characteristics, Therapeutic
Strategies and Nanomedicine
Authors: Cai Yuxuan , Wang Bei , Xu Wen , Liu Kai , Gao Yisong , Guo Chong , Chen Jinlan , Kamal Mohammad Amjad , Yuan Chengfu
Published: July 2021

Background:

Endometrial cancer is the fourth most common malignancy in female
population worldwide. It was estimated that 65,620 new cases and 12.590 subsequent
deaths occurred in 2020 in the United States. Patients with type II and advanced endometrial
cancer do not respond well to the current treatments. Therefore, endometrial
cancer should be better understood in order to develop more effective treatments.

Objective:

To provide an overview of genetic, metabolic characteristics, therapeutic
strategies and current application of nanotechnology surrounding endometrial cancer.

Method:

Relevant articles were retrieved from Pubmed and were systematically reviewed.

Results:

Hypoxia inducible factor-1 and Von Hippel-Lindau factor participated in oncogenesis
and progression of endometrial cancer and Nrf2 was associated with oncogenesis.
Various genetic alterations were found in endometrial cancer. Examining the abnormal
X chromosome inactivation may help in the diagnosis of endometrial cancer and its
precancerous lesions. Some absent tumor suppressor genes, activated oncogenes were revealed
by the genetically modified mouse models. Disorders in glucose and lipid
metabolism were found in endometrial cancer. Current therapeutic strategies focused on
the HIF-1α pathway, the mTOR pathway as well as the immunotherapy. Nanotechnology
showed great potential in endometrial cancer’s early diagnosis, metastasis determination
and treatment.

Conclusion:

Endometrial cancer has been understood in various aspects but the underlying
mechanisms still remain relatively unknown, which might be the source of novel diagnostic,
prognostic and therapeutic targets. Nanomedicine in endometrial cancer is poorly
studied but the current researches showed great results in treating endometrial cancer. It
needs further researching.
Biogenic Gas Vesicles for Ultrasound Imaging and Targeted Therapeutics
Authors: Wang Rui , Wang Lufang , Chen Yihan , Xie Yuji , He Mengrong , Zhu Ye , Xu Lingling , Han Zhengyang , Chen Dandan , Jin Qiaofeng , Zhang Li , Xie Mingxing
Published: July 2021

:

Ultrasound is not only the most widely used medical imaging mode for diagnostics
owing to its real-time, non-radiation, portable and low-cost merits, but also a
promising targeted drug/gene delivery technique by producing a series of powerful bioeffects.
The development of micron-sized or nanometer-sized ultrasound agents or delivery
carriers further makes ultrasound a distinctive modality in accurate diagnosis and effective
treatment. In this review, we introduce one kind of unique biogenic gas-filled protein
nanostructures called gas vesicles, which present some unique characteristics beyond the
conventional microbubbles. Gas vesicles can not only serve as ultrasound contrast agent
with innovative imaging methods such as cross-amplitude modulation harmonic imaging,
but also can further be adjusted and optimized via genetic engineered techniques. Moreover,
they could not only serve as acoustic gene reporters, acoustic biosensors to monitor
the cell metabolism, but also serve as cavitation nuclei and drug carrier for therapeutic
purpose. We focus on the latest development and applications in the area of ultrasound
imaging and targeted therapeutics, and also give a brief introduction to the corresponding
mechanisms. In summary, these biogenic gas vesicles show some advantages over conventional
MBs that deserve making more efforts to promote their development.
Application of Combined Prediction Model Based on Core and Coritivity
Theory in Continuous Blood Pressure Prediction
Authors: Zhou Kai , Yin Zhixiang , Guo Fei , Li Jiasi
Published: July 2021

Background and Objective:

Blood pressure is vital evidence for clinicians to predict
diseases and check the curative effect of diagnosis and treatment. To further improve the prediction
accuracy of blood pressure, this paper proposes a combined prediction model of blood pressure
based on coritivity theory and photoplethysmography.

Method:

First of all, we extract eight features of photoplethysmogram, followed by using eight
machine learning prediction algorithms, such as K-nearest neighbor, classification and regression
trees, and random forest, to predict systolic blood pressure. Secondly, aiming at the problem of
sub-model selection of combination forecasting model, from the point of graph theory, we
construct an undirected network graph G, the results of each single prediction model constitute a
vertex set. If the maximum mutual information coefficient between vertices is greater than or
equal to 0.69, the vertices are connected by edges. The maximum core of graph G is a submodel of
the combinatorial model.

Results:

According to the definition of core and coritivity, the maximum core of G is random
forest regression and Gaussian kernel support vector regression model. The results show that the
SDP estimation error of the combined prediction model based on random forest regression and
Gaussian kernel support vector regression is 3.56 ±5.28mmhg, which is better than other single
models and meets the AAMI standards.

Conclusion:

The combined model determined by core and coritivity has higher prediction
performance for blood pressure.
Novel Drug Delivery System for Curcumin: Implementation to Improve
Therapeutic Efficacy against Neurological Disorders
Authors: Mohi-ud-din Roohi , Mir Reyaz Hassan , Wani Taha Umair , Shah Abdul Jalil , Mohi-Ud-Din Ishtiyaq , Dar Mudasir Ahmad , Pottoo Faheem Hyder
Published: July 2021

Background:

Curcumin, a hydrophobic polyphenolic compound present in Curcuma
longa Linn. (Turmeric), has been used to improve various neurodegenerative conditions, including
Amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Prion disease, stroke,
anxiety, depression, and ageing. However, the Blood-Brain Barrier (BBB) impedes the delivery of
curcumin to the brain, limiting its therapeutic potential.

Objective/Aim:

This review summarises the recent advances towards the therapeutic efficacy of
curcumin along with various novel strategies to overcome its poor bioavailability across the bloodbrain
barrier.

Methods:

The data for the compilation of this review work were searched in PubMed Scopus,
Google Scholar, and Science Direct.

Result:

The review also summarises the numerous toxicological studies and the role of
curcumin in CNS disorders.

Conclusion:

The review also summarises the numerous toxicological studies and the role of
curcumin in CNS disorders.
Current Designs of Polymeric Platforms Towards the Delivery of Nucleic Acids Inside the Cells with Focus on Polyethylenimine
Authors: de Oliveira Fernando A. , Albuquerque Lindomar J.C. , Delecourt Gwendoline , Bennevault Véronique , Guégan Philippe , Giacomelli Fernando C.
Published: July 2021

Background:

Gene delivery is a promising technology for treating diseases linked to abnormal
gene expression. Since nucleic acids are the therapeutic entities in such approach, a transfecting
vector is required because the macromolecules are not able to efficiently enter the cells by themselves.
Viral vectors have been evidenced to be highly effective in this context; however, they suffer
from fundamental drawbacks, such as the ability to stimulate immune responses. The development of
synthetic vectors has accordingly emerged as an alternative.

Objectives:

Gene delivery by using non-viral vectors is a multi-step process that poses many challenges,
either regarding the extracellular or intracellular media. We explore the delivery pathway and afterwards,
we review the main classes of non-viral gene delivery vectors. We further focus on the progresses
concerning polyethylenimine-based polymer-nucleic acid polyplexes, which have emerged as
one of the most efficient systems for delivering genetic material inside the cells.

Discussion:

The complexity of the whole transfection pathway, along with a lack of fundamental understanding,
particularly regarding the intracellular trafficking of nucleic acids complexed to non-viral
vectors, probably justifies the current (beginning of 2021) limited number of formulations that have
progressed to clinical trials. Truly, successful medical developments still require a lot of basic research.

Conclusion:

Advances in macromolecular chemistry and high-resolution imaging techniques will be
useful to understand fundamental aspects towards further optimizations and future applications. More
investigations concerning the dynamics, thermodynamics and structural parameters of polyplexes
would be valuable since they can be connected to the different levels of transfection efficiency hitherto
evidenced.
Molecular Simulation Studies of Alpha Pinene, an Alkene in Search for Oxidative Stress Targeted Therapeutic Paradigms for the Treatment of Parkinson’s Disease: A Computational Approach and Its In-Vitro Antioxidant Validation
Authors: Srivastava Rajnish , Choudhury Pratim Kumar , Dev Suresh Kumar , Rathore Vaibhav
Published: July 2021

Aim:

The present study was expected to explore the molecular interaction of five oxidative
stress (OS) associated target receptors with Alpha-Pinene and its antioxidant validation for the
effective treatment of Parkinson’s disease (PD).

Background:

Oxidative stress (OS) via multitudinous cascades is considered to be the leading attribute
to dopaminergic cell degeneration in PD. Furthermore, it is also well-linked to other mechanisms
involved in the neurodegeneration process, like dysfunction of mitochondria, neuroinflammation and
excitotoxicity due to NO.

Objective:

The present investigation was to establish a molecular association of OS-associated target
receptors with the bio

Material and Method:

Five different molecular targets namely Peroxisome Proliferator-Activated
Receptor- Gamma (PPARγ), Liver-X receptor beta (LXR- β), Human Monoamine Oxidase-B
(MAO-B), Human Nuclear receptor related-1 protein (Nurr1) and Human Lipoprotein-associated
phospholipase A2 (Lp-PLA2) were obtained from RCSB-PDB, which has some leading association
in the inhibition of the OS-induced neurodegeneration. Molecular interactions were stuffed by the
simulation molecular docking software. Antioxidant activity was validated by in-vitro models as per
standardized procedures against 2,2- diphenyl-1- picrylhydrazyl (DPPH), 2,2'-azinobis-(3-
ethylbenzothiazoline -6-sulfonic acid) (ABTS), Ferric ion (Fe3+), Hydroxyl (•OH), nitric oxide
(•NO), Peroxynitrite (ONOO-) and Hypochlorous acid (HOCl).

Result:

Our results indicated that alpha-pinene can interact with all the five different target receptors
at the active binding site. Alpha-pinene was found to show better interaction with MAO-B,
Nurr1 and PPARγ with binding energy of -5.50, -4.52 and -5.25, respectively as compared to the
native ligand. Furthermore, the interaction of alpha-pinene with LXR-β and Lp-PLA2 was also significant
with binding energy of -5.6 and -5.12, respectively. It also capable of neutralizing
all the different free radicals under consideration with significant IC50 values against HOCl and
•NO.

Conclusion:

It might be concluded that alpha-pinene could act as a potential inhibitor and scavenger
of OS which could act on the multiple target receptors under consideration.
Evaluation of By-Products of Potato Peel as Food Additive
Authors: Yuksel Ferhat , Durmaz Aysun
Published: July 2021

The potato plant is an important food source produced all over the world and it provides a significant portion of daily energy intake in nourishment. In addition, a significant rate of vitamins, fibre, mineral matters, protein, and fat can be obtained by consuming potato. In this study, the production, consumption, and usage areas of potato, a crucial source of our diet, and the possibilities of using it as food additives with the nutritional properties of its peel have been investigated. Generally, potato is consumed after its peel is removed in the homes and industrial areas and many of these peels are disposed off as wastes. Studies show that potato peel has a high content of dietary fibre, protein, carbohydrate, mineral matters, vitamin, phenolic, and antioxidant. The use of potato peel as food additives have also been discussed in this study.
Diagnostic Performance of Radiology Residents in Thoracic CT Imaging
in Emergency Radiology During The COVID-19 Pandemic
Authors: Cakmak Vefa , Herek Duygu , Cakmak Pinar
Published: July 2021

Background:

During the COVID-19 pandemic, the workload of all radiologists and radiology
residents, as well as other clinical physicians, has increased.

Introduction:

This study aims to determine the diagnostic performance of radiology residents, who
effectively contribute to the diagnosis of COVID-19.

Methods:

The thoracic Computed Tomography (CT) images of 135 patients aged 20–83 diagnosed
with COVID-19 were evaluated retrospectively by five radiology residents and a radiologist with
10 years of experience. The diagnostic performance of the radiology residents in evaluating
COVID-19 was assessed according to their year of residency and the patients’ age and gender. Receiver
Operating Characteristic (ROC) curve analysis was performed to determine the sensitivity
and specificity of radiology residents.

Results:

The radiology residents’ performance in determining COVID-19 using CT findings was
evaluated as follows: sensitivity 97.22%, specificity 88.89%, positive predictive value 90.91%, negative
predictive value 96.55%, and accuracy 93.33%. According to the year of residency, the sensitivity
and specificity of the radiology residents in determining COVID-19 using CT images were
between 92.3% and 100%, and 71.43% and 100%, respectively.

Conclusion:

The high sensitivity and specificity of radiology residents in evaluating thoracic CT
images for COVID-19 diagnosis indicate that radiologists are as important as clinical physicians in
the diagnosis of COVID-19.
SIX SIGMA IMPLEMENTATION IN INDONESIA INDUSTRIES AND BUSINESSES: A SYSTEMATIC LITERATURE REVIEW
Authors:   Universitas Mercu Buana Jakarta, Widjajanto Sugiri , Hardi Purba Humiras
Published: July 2021

Understanding quality in manufacturing starts with defect identification and improvement finding. Reliability that influenced by equipment design or working methods or environment has led to concept of improvement with six sigma method and this has been absorbed in Indonesia industries as well. This article discusses about six sigma implementation in Indonesia from various business and industries. The method is to review research articles that are published within 2016-2020 with keyword DMAIC and six sigma. The results from 52 selected articles is obtained average 3.68 sigma value of Indonesia industries within year 2016-2020 with the least value 1.10 from crude palm oil refinery and the highest is 5.10 from bagging process of sugar refinery. However, six sigma application is not always satisfying concerning its suitability function, requirement of industries, culture, local regulation, and internal business concern, especially in terms of efficiency and cost. Future research is suggested utilizing industry 4.0 concept to enhance six sigma implementations.
PENGEMBANGAN MEDIA PELAJARAN BERBASIS APLIKASI ANDROID DENGAN AUGMENTED REALITY UNTUK MATA PELAJARAN GAMBAR TEKNIK KELAS X KONTRUKSI GEDUNG, SANITASI DAN PERAWATAN DI SMK NEGERI 1 SEYEGAN
Authors: Raharjo Nuryadin Eko , Pitaloka Galuh Kemuning
Published: July 2021

Kajian ini  bertujuan untuk mengembangkan media pembelajaran berbasis aplikasi android dengan augmented reality pada mata pelajaran Gambar Teknik dengan model Waterfall. Kajian ini merupakan penelitian Research and Development (R&D) dengan menggunakan model pengembangan Linear sequential model atau Waterfall Model. Model Waterfall dilaksanakan melalui tahapan analisis, desain, pengodean, dan pengujian. Hasil kajian ini sebagai berikut. (1) Pada tahap analisis diketahui bahwa siswa diperbolehkan menggunakan memakai smartphone sebagai media pembelajaran, media pembelajaran masih kurang variatif dan metode guru mengajar masih konvensional. Software yang digunakan adalah Unity 3D, Corel Draw X8, dan Adobe Photoshop CS6. Spesifikasi minimum smartphone yang dibutuhkan android versi 4.0 Jellybean, RAM 768 MB dan kamera 5MP. (2) Tahap desain menghasilkan rancangan Unified Modeling Language (UML), dan desain antarmuka (user interface). (3) Pada tahap pengodean dihasilkan aplikasi android, implementasi dari desain Unified Modeling Language (UML) dan desain antarmuka (user interface). (4) Tahap pengujian dilaksanakan dengan uji materi dan uji media menurut ISO 25010. Hasil uji materi oleh ahli materi dari aspek kualitas isi dan tujuan serta aspek kualitas pembelajaran memperoleh nilai presentase 92,7% kategori sangat Layak. Pengujian aspek functional suitability oleh ahli media memperoleh nilai presentase 100% berada pada kategori sangat layak. Aspek compatibility sub kategori co-existence dan hasil uji pada berbagai tipe perangkat masing-masing memperoleh skor 100% dengan kategori sangat layak. Pengujian aspek usability memperoleh skor 79,8 dengan kategori baik. Aspek performance efficiency telah memenuhi standar dan berada pada performance efficiency yang baik.
PENGEMBANGAN MEDIA PEMBELAJARAN VIDEO ANIMASI UNTUK MATA PELAJARAN MEKANIKA TEKNIK KELAS X DESAIN PEMODELAN DAN INFORMASI BANGUNAN DI SMK N 2 YOGYAKARTA
Authors: Titania Tiara , Widodo Slamet
Published: July 2021

Penelitian ini dilaksanakan untuk mengembangkan media pembelajaran animasi untuk mekanika teknik berdasarkan kurikulum SMK 2013 Revisi 2016 yang layak dan dapat menjadi alternatif sumber belajar siswa. Penelitian ini termasuk penelitian dan pengembangan atau Research and Development (R&D) dengan model penelitian 4D (Define, Design, Development and Disseminate) dan disesuaikan dengan kebutuhan. Pengumpulan data menggunakan angket ahli dan kuisioner didukung dengan kegiatan observasi. Angket ahli diberikan kepada ahli materi, ahli media dan angket kuisioner diberikan untuk pengguna (guru pengampu Mekanika Teknik SMK N 2 Yogyakarta). Hasil penelitian ini berupa media pembelajaran video animasi untuk mata pelajaran Mekanika Teknik dengan hasil setiap tahap sebagai berikut: (1) Hasil tahap define adalah analisis kebutuhan awal yaitu siswa belum mengetahui konsep dari pemodelan struktur, cara belajar setiap siswa yang berbeda dan media yang digunakan kurang bervariasi. Analisis konsep menghasilkan konsep tampilan media secara umum dan analisis tugas menghasilkan penetapan kompetensi dasar yang menyesuaikan dengan analisis kebutuhan awal untuk kemudian dirumuskan tujuan pembelajarannya; (2) Hasil tahap design adalah susunan materi berdasarkan kompetensi dasar dan indikator yang telah ditetapkan. Hasil akhir media berformat .exe terdiri dari animasi, video dan teks; (3) Hasil tahap development berupa nilai dari validasi ahli dan calon pengguna sebagai berikut: a) penilaian ahli materi pada media pembelajaran animasi mekanika teknik mendapatkan skor 68 dan persentase 100% dan dinyatakan bahwa media sangat layak, b) penilaian ahli media pada animasi media pembelajaran mekanika teknik mendapatkan skor 84 dan persentase 91,6% dan dinyatakan bahwa media sangat layak, dan c) penilaian dari uji coba calon pengguna pada media pembelajaran video animasi mekanika teknik mendapatkan rata-rata skor 39,5 dan persentase 76,3%  dan dinyatakan bahwa media layak digunakan.
PENGEMBANGAN VIDEO PEMBELAJARAN OPEN STREET MAP UNTUK PEMBUATAN PETA DIGITAL FORMAT SHAPEFILE MENGGUNAKAN SPATIAL MANAGER
Authors: Marsudi Ilham , Ramadani Febtri Yanna , Rochmadi Sunar , Raharjo Nuryadin Eko , Hidayat Nur
Published: July 2021

Tujuan penelitian ini adalah mengembangkan video pembelajaran OpenStreetMap untuk pembuatan peta digital format shapefile menggunakan Spatial Manager. Penelitian ini termasuk dalam jenis penelitian pengembangan (Research and Development/R&D) yang mengacu pada model pengembangan 4D (Define, Design, Development, and Disseminate) oleh Thiagarajan. Teknik pengumpulan data menggunakan angket yang diberikan kepada ahli materi, ahli media, dan pengguna (mahasiswa). Teknik analisis data menggunakan teknik analisis deskriptif kuantitatif. Hasil penelitian dan pengembangan media pembelajaran memperoleh kesimpulan sebagai berikut: (1) Tahap define menghasilkan kebutuhan pembelajaran tentang OpenStreetMap untuk pembuatan peta digital format shapefile menggunakan Spatial Manager; (2) Tahap design menghasilkan flowchart, storyboard, dan take video yang sesuai serta produk yang dihasilkan berupa video pembelajaran dengan teknik animasi dan screen record berformat *.mp4 yang dapat diputar di komputer/laptop maupun smartphone standar, berdurasi selama 15 menit 50 detik, dan ukuran file sebesar 56,7 MB; (3) Tahap development menghasilkan penilaian tingkat kelayakan media video pembelajaran yang dikembangkan berdasarkan penilaian oleh ahli materi adalah 90,91 % termasuk dalam kategori “layak”, sedangkan penilaian oleh ahli media adalah 91,13 % termasuk dalam kategori “layak”, dan penilaian pengguna (mahasiswa) adalah 86,62 % termasuk dalam kategori “layak”; (4) Tahap disseminate merupakan penyebarluasan hasil penelitian berupa produk video yang diunggah melalui platform Youtube dan memberikan file kepada pengguna.
PENGARUH KEPEMIMPINAN MUTU DAN KEWIRAUSAHAAN KEPALA SEKOLAH TERHADAP KETERCAPAIAN SNP DI SMKN 1 PURWOREJO
Authors: Alayda Faya Izma , Wahyuni Indah
Published: July 2021

Tujuan penelitian mengetahui tingkat ketercapaian 1) kepemimpinan mutu, 2) kepemimpinan kewirausahaan, dan 3) SNP; mengetahui besarnya pengaruh 4) kepemimpinan mutu terhadap SNP, 5) kepemimpinan kewirausahaan terhadap SNP, 6) kepemimpinan mutu dan kewirausahaan secara bersama-sama terhadap SNP; dan 7) mengetahui hubungan kepemimpinan mutu dengan kewirausahaan. Merupakan penelitian prediksi korelasi dengan pendekatan kuantitatif deskriptif. Subjek penelitiannya 130 orang tenaga pendidik dan kependidikan dengan sampel 30 orang. Menggunakan instrumen angket tertutup melalui google form menggunakan skala likert 1 sampai 4. Teknik analisis data menggunakan analisis deskriptif dan regresi. Hasil penelitian menunjukkan tingkat ketercapaian 1) kepemimpinan mutu dengan kategori sangat baik (67,742%), 2) kepemimpinan kewirausahaan dengan kategori baik (61,3%), 3) ketercapaian SNP dengan kategori sangat tinggi (90,32%), 4) kepemimpinan mutu berpengaruh positif terhadap SNP (26,8%), 5) kepemimpinan kewirausahaan berpengaruh positif terhadap SNP (35,3%), 6) kepemimpinan mutu dan kewirausahaan secara bersama-sama berpengaruh positif terhadap SNP (56,4%), 7) tidak terdapat hubungan kepemimpinan mutu dan kewirausahaan.
PENGEMBANGAN MEDIA PEMBELAJARAN AUGMENTED REALITY FOR BRIDGE PADA MATA PELAJARAN KONSTRUKSI JALAN DAN JEMBATAN UNTUK SMK KELAS XI DPIB
Authors: Raharjo Nuryadin Eko , Dinata Candra
Published: July 2021

Tujuan penelitian ini untuk mengembangkan media pembelajaran Augmented Reality for Bridge (ABRI) pada mata pelajaran konstruksi jalan dan jembatan kelas XI DPIB di SMK N 2 Depok Sleman. Penelitian ini dilaksanakan dengan metode Research and Development (R&D) dengan menggunakan model pengembangan waterfall. Model pengembangan waterfall memiliki tahap: analisis, desain, pengkodean, dan pengujian. Hasil dari penelitian ini sebagai berikut: 1) Pada tahap analisis, masalah yang ditemukan yaitu media pembelajaran yang digunakan kurang inovatif dan interaktif, mengakibatkan pemahaman siswa terhadap materi pelajaran yang disampaikan masih abstrak. Diperoleh beberapa aplikasi yang akan digunakan untuk membuat media ini seperti AutoCAD, StarUML, Unity 3D dan Adobe Photoshop; 2) Pada tahap desain, perancangan gambar 2D dilakukan menggunakan aplikasi AutoCAD serta perancangan Unified Model Language (UML). Hasil dari UML terdiri dari use case diagram, activity diagram, dan sequence diagram; 3) Pada tahap pengkodean, hasil yang didapatkan berupa interface (tampilan antar muka) aplikasi yang merupakan hasil dari pengembangan rancangan yang dibuat pada tahap desain; 4) Pada tahap pengujian, terdiri dari pengujian materi dan media pembelajaran yang mengacu standar ISO 25010. Dari hasil pengujian yang sudah dilakukan, tingkat kategori rata-rata yang didapatkan adalah “Sangat Layak”.
Determinant factors affecting the improvement of education index
Authors: Jamal Jalil Setiawan , Salam Muslim , Tenriawaru Andi Nixia , Rukmana Didi , Jamil Muhammad Hatta , Saadah Saadah
Published: July 2021

The Human Development Index (HDI) of the Selayar Islands Regency experienced an insignificant improvement. The low education index causes the low HDI achievement of the Selayar Islands Regency because the achievement of education index is lower than the health index and the expenditure index. Therefore, it is very necessary to improve the education index. This study aims to analyze the factors that influence the education index. This study uses secondary data in the form of panel data which is a combination of time series data from 2014 to 2019 and cross section data from 11 sub-districts. Panel data to measure the factors that affect the Education Index were analyzed using regression analysis. The results showed that the teacher to student ratio at elementary school had a negative effect on the education index, the class to student ratio at elementary school had a positive effect on the education index, while the school to student ratio at elementary school, school to student ratio at junior high school, class to student ratio at junior high school and teacher to student ratio at junior high school had no effect on the education index.
Egészségmagatartási tényezők klaszteranalízise a Magyar Honvédségben
Authors: Novák Attila , Nyakas Csaba , Rázsó Zsófia , Sótér Andrea
Published: July 2021

Az egészségmagatartás tényezőit, amelyek – a megelőzés szempontjából – mind az egyén, mind a közösség számára létfontosságúak, egy speciális populációban, a Magyar Honvédség személyi állománya körében vizsgáltuk, ahol az erő és az egészség egyaránt a szakma szimbóluma. A keresztmetszeti vizsgálatunk mintáját azok a katonák alkották (N = 5475), akik 2012 és 2015 között kötelező foglalkozás-egészségügyi alkalmasság felmérés keretében kitöltötték a prevenciós adatlapot. A vizsgálat alá vont egészségi és egészségmagatartási tényezők értékeléséhez a pontozási rendszert tudományos szakirodalom felhasználásával alakítottuk ki, majd a homogén csoportok kialakítása érdekében hierarchikus klaszteranalízist alkalmaztunk. 16 homogén, és egymástól megkülönböztethető egészségmagatartási csoportot (profilt) vizsgáltunk, amelyek közül 10 szignifikánsan (p <0,05) különbözött egymástól. Az összesen 24 vizsgált tényezőre adott válaszlehetőségeket lineáris skálán értékeltük, melynek minimuma -47,5, maximuma 48,5 pont lehetett. A legalacsonyabb pontszámú klaszter 3,1, a legmagasabb 26,2 pont volt. A legalacsonyabb pontszámú klaszterben (a minta 1,8% -a) volt a legmagasabb az átlagéletkor (43,5 + 7,2 év), és a legmagasabb a nők aránya (46%). A legmagasabb pontszámmal rendelkező két klaszterben (a minta 2,9% -a és 5,5% -a) volt a legalacsonyabb az átlagéletkor (33,7 + 7,1 év és 34,3 + 7,9 év). A vizsgálatban résztvevők közül a legjobb eredményeket elérők is több, mint 20 ponttal elmaradnak az elérhető maximális pontszámtól, továbbá elmondható, hogy az életkor növekedésével az egészségmagatartási tényezők jelentősen romlanak, különösen a nők körében. Az eredményekből kiderült, hogy minden klaszter esetében intervencióra van szükség, és megállapítható, hogy melyik egészségmagatartási faktorral érhetjük el a legnagyobb egészségügyi hozadékot.