bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective modulation of epileptic tissue by an adenosine A3 receptor-activating drug
Authors: Sebastião Ana Maria , Ghosh Anwesha , Ribeiro-Rodrigues Leonor , Ruffolo Gabriele , Alfano Veronica , Domingos Catia , Rei Nadia , Tosh Dilip , Rombo Diogo , Morais Tatiana , Valente Claudia , Xapelli Sara , Bordadágua Beatriz , Rainha-Campos Alexandre , Bentes Carla , Aronica Eleonora , Diógenes Maria José , Vaz Sandra , Ribeiro Joaquim Alexandre , Palma Eleonora , Jacobson Kenneth
Published: August 2024

Background and Purpose Adenosine, through the A1 receptor (A1R), is an
endogenous anticonvulsant. Development of adenosine receptor agonists as
antiseizure medications has been hampered by their cardiac side effects.
A moderately A1R-selective agonist, MRS5474, has been reported to
suppress seizures without considerable cardiac action. Hypothesizing
that this drug could act through other than A1R and/or through a disease
specific mechanism, we assessed the effect of MRS5474 on the
hippocampus. Experimental Approach Excitatory synaptic currents, field
potentials, spontaneous activity, [3H]GABA uptake and GABAergic
currents were recorded from rodent or human hippocampal tissue.
Alterations in adenosine A3 receptor (A3R) density in human tissue were
assessed by Western Blot. Key Results MRS5474 (50-500nM) was devoid of
effect upon rodent excitatory synaptic signals in hippocampal slices,
except when hyperexcitability was previously induced in vivo or ex vivo.
This contrasted with the effect of other A1R agonists. MRS5474 inhibited
GAT-1 mediated GABA uptake, an action not blocked by an A1R antagonist
but blocked by an A3R antagonist and mimicked by an A3R agonist. A3R was
overexpressed in human hippocampal tissue samples from patients with
epilepsy that had focal resection from surgery. MRS5474 induced a
concentration-dependent potentiation of GABA-evoked currents in oocytes
micro-transplanted with human hippocampal membranes prepared from
epileptic hippocampal tissue but not from non-epileptic tissue, an
action blocked by an A3R antagonist. Conclusion and Implications We
identified a drug that activates A3R and has selective actions on
epileptic hippocampal tissue. This underscores A3R as a promising target
for the development of antiseizure medications.
Puntos de ruptura y convergencia en los proyectos de vanguardia latinoamericanos y europeos de inicio del siglo veinte.
Authors: Guzmán Lagreze Emilio ,   Pontificia Universidad Católica de Chile
Published: August 2024

El artículo propone articular un análisis comparativo entre las vanguardias europeas de comienzos del siglo veinte, en su relación con las vanguardias andinas de Chile y Perú del mismo período, a partir de los debates culturales, estéticos y políticos desarrollados en las redes culturales de revistas como Amauta o el Boletín Titikaka, así como las revistas europeas tales como MA, para comprender los puntos de convergencia y de ruptura en la recepción Latinoamericana de los movimientos de vanguardia europeos durante el mismo período histórico.
La litoralización de Tarapacá durante el proceso de mundialización del nitrato de soda (1867-1919): de la violencia política a la violencia económica
Authors: González Miranda Sergio ,   Universidad de Tarapacá, Chile, Galaz-Mandakovic Fernández Damir ,   Universidad Católica del Norte, Chile
Published: August 2024

Con el ciclo del salitre la provincia peruana de Tarapacá inició un proceso de mundialización del salitre, especialmente a partir del gobierno de José Balta (1868-1872), coincidente con el primer boom industrial del salitre, producto de la consolidación de la máquina de vapor en el proceso de lixiviación del nitrato. Esta lenta mundialización del salitre generó un cambio estructural en este territorio, transitando desde una provincia dependiente del departamento de Moquegua a otra plenamente autónoma al alcanzar la calidad de provincia litoral. Adicionalmente, el surgimiento de asentamientos poblacionales en el desierto (oficinas salitreras, pueblos de servicios, estaciones ferroviarias) y, principalmente, puertos de embarque en la costa, presionaron por un nuevo orden político-administrativo y un nuevo ordenamiento territorial, cuya principal consecuencia sería el cambio desde la tradicional capital de la provincia (San Lorenzo de Tarapacá) hacia el puerto de Iquique. Este cambio que demoraría aproximadamente una década generó resistencia que alcanzó a la violencia política. El ciclo de expansión salitrero alcanzará su máxima expresión durante el periodo de la administración política chilena de esta provincia —iniciado en 1880 y concluido en 1918— donde el proceso de litoralización de la provincia de Tarapacá generaría otros conflictos (competencia entre puertos) caracterizados por la violencia económica durante el proceso de consolidación de la plataforma portuaria exportadora de salitre.
¿Hegemonía o complementariedad? El eje Valparaíso-Callao en el comercio transpacífico, 1830-1848
Authors: Lacoste Adunka Michelle ,   Pontificia Universidad Católica de Chile
Published: August 2024

Este trabajo propone, desde el enfoque de la Historia Global, que a fin de comprender el comercio transpacífico entre América del Sur y Asia en la primera mitad del siglo XIX es necesario entender a los puertos de Valparaíso y Callao como ejes articuladores de un sistema portuario, lo que cuestiona la hipótesis de la hegemonía de Valparaíso en el Pacifico Sudamericano. Al aumentar la escala de análisis, incluyendo el comercio con Asia, se observa que incluso la guerra entre Chile y la Confederación Peruano-boliviana no interrumpió la complementariedad de los mercados de la costa del Pacífico sudamericano. A fin de comprobar la hipótesis, se analiza la Estadística Comercial de Chile, para evaluar la importancia del comercio bilateral en este periodo. También se revisan los registros de las Capitanías de Puerto de Valparaíso y Callao, para determinar la cantidad de embarcaciones que pasaban por ambos puertos antes de atravesar el Océano Pacífico, y al retornar. Finalmente, se estudian dos casos de expediciones comerciales a China, organizadas en América del Sur, una desde Valparaíso y otra desde el Callao. Como conclusión, se afirma que la complementariedad de ambas plazas fue fundamental para hacer rentable el comercio transpacífico.
LINGUISTIC FEATURES OF AUTHOR’S NEOLOGISMS IN J. K. ROWLING’S NOVEL “HARRY POTTER AND THE PHILOSOPHER’S STONE”
Authors: Vasylenko Oksana , Vozniuk Liudmyla
Published: August 2024

The article deals with the neologisms of J. Rowling who is famous for her creation of Harry Potter series and she is also known for her clever use of language, including the invention of new words and phrases. These neologisms add depth and richness to the wizarding world she has created. There are several ways of creating author’s neologisms, among which syntactic (word-forming derivation), semantic (changes in the meaning of a word, its reinterpretation) and borrowing prevail. It is revealed that J. Rowling formed neologisms using word-forming derivation (suffixing, word formation and abbreviation and semantic derivation but there are no neologisms formed by the morphological type of stem formation in the first two books. The main functions performed by neologisms in the novel are originality, creativity and expressiveness. These neologisms have become integral parts of the Harry Potter universe and have contributed to its enduring popularity. They demonstrate Rowling’s creativity as a writer and her ability to bring her fictional world to life through language.
Comprehensive Study on Pharmaceutical Delivery: Mouth Dissolving Tablets
Authors: S* Kiran , S Khemchand , J Shivraj , P Dhananjay
Published: August 2024

Fast-disintegrating tablets are one of the most often utilized dose forms available, particularly for youngsters whose nervous and muscular systems are still developing in comparison to adults. in grownups. and in adult individuals who have hand tremors or Parkinson's disease. Due to swallowing difficulties caused by dysphagia, many fixed dose forms, including tablets and capsules, no longer comply with prescribed dosages, making therapy ineffective. Oral dosage forms and the oral route with certain constraints, such as first-pass liver metabolism, mental patients, at-risk patients, and non-co-operators, are the most recommended modes of administration for many medications. MDTs don't require water to dissolve; saliva does the heavy lifting. Saliva dissolves mouth dissolving tablets in less than 60 seconds at the very least. Additionally, these tablets digest incredibly quickly. Super disintegrates are added to MDT formulations to speed up the pace at which tablets break down in the buccal cavity. MDTs are advantageous due to their ease of manufacturing, appropriate dosage, strong chemical and physical makeup, and suitability as a substitute for both adult and pediatric patients. Due to MDTs' quicker rate of absorption and breakdown, the drug's dose form and in vitro release duration both lengthen and improve bioavailability. Both in traditional tablet and liquid dosing forms, MDT formulations provide unique benefits. There are numerous processes available for mass extrusion, direct freeze pressing/lyophilization, sublimation, cotton candy, phase transition, spray drying, and melt granulation. This review gives a quick introduction of MDT, covering its definition, advantages, requirements, and essential features. It also discusses its limitations, different development obstacles, and commercially available tablet formulations that promote rapid digestion, among other things.
Studi Literatur: Karakteristik Aspal Penetrasi 60/70 yang Ditambahkan Serat Limbah Masker Medis
Authors: Putra I Gusti Agung Ananda
Published: August 2024

Masker adalah jenis perlindungan pernafasan yang digunakan untuk mencegah orang menghirup bahan bahaya atau kontaminasi di udara. Walaupun penting untuk menggunakan masker demi mencegah penyebaran virus Corona, pembuangan masker dapat membahayakan lingkungan. Secara umum, masker medis mengandung polipropilena dalam komposisi kimianya. Pada review ini akan dibahas serat dari limbah masker dijadikan bahan aditif untuk mengevaluasi dampaknya terhadap sifat-sifat aspal Metode yang dipakai adalah studi literatur dari peneliti terdahulu. Hasil penelitian menunjukkan bahwa penambahan limbah masker medis ke dalam aspal penetrasi 60/70 dapat meningkatkan kekakuan, mengurangi sensitivitas suhu aspal, meningkatkan viskositas, serta meningkatkan viskoelastisitas dan ketahanan deformasi aspal.
Kajian Risiko Eskalasi (Price Escalation) terhadap Harga Solar Industri pada Proyek Konstruksi
Authors: Novrizal Dedi , Hermawan Ferry , Wibowo Mochamad Agung
Published: August 2024

Dalam upaya meningkatkan efisiensi dan keberlanjutan proyek konstruksi yang dibiayai pemerintah, penelitian ini menyelidiki dampak penggunaan harga jual solar non-subsidi Pertamina dalam perhitungan eskalasi biaya pada proyek konstruksi multi-years. Dengan fokus pada dua proyek konstruksi besar di Provinsi Jawa Tengah, penelitian ini menggunakan metode kualitatif dan analisis numerik untuk membandingkan efektivitas penggunaan harga jual Pertamina dibandingkan dengan indeks Badan Pusat Statistik (BPS) dalam perhitungan eskalasi biaya. Metode penelitian menggabungkan analisis data primer yang dikumpulkan melalui survei, wawancara dengan kontraktor dan penggunaan model eskalasi biaya berbasis indeks harga. Hasil penelitian menunjukkan bahwa penggunaan harga jual Pertamina menghasilkan estimasi biaya yang lebih tinggi, namun lebih akurat dan mendekati kondisi pasar aktual, yang berpotensi mengurangi risiko keuangan proyek. Penelitian ini menawarkan wawasan baru tentang pengelolaan biaya proyek dan mendukung kebutuhan akan pendekatan yang lebih dinamis dan responsif dalam pengelolaan risiko eskalasi biaya, yang relevan bagi kontraktor dan pemangku kepentingan dalam proyek konstruksi pemerintah. Implikasinya menunjukkan pentingnya penyesuaian kebijakan dan praktik perhitungan biaya untuk mengakomodasi fluktuasi harga pasar, sehingga memastikan keberlanjutan finansial dan keberhasilan proyek konstruksi.
Brand identity in the digital age : complexity and contradiction
Authors: Petitimbert Jean-Paul
Published: August 2024

The exponential speed at which markets are invaded by the trend towards digitalisation (with the advent of social media in particular), together with other influences such as globalisation, all-out diversification, and the race to innovate, have made brand management a perilous exercise. The need for brands to communicate constantly with their multiple audiences has led them to prioritise impact over content. In doing so, they often blatantly contradict themselves. The semi-symbolic model of brand identity, as adopted by semioticians following J.-M. Floch, no longer functions in its symmetrical purity. This article therefore discusses its possible adaptation to current developments and, on this basis, proposes to consider the introduction of the notion of “included middle” into the corpus of the fundamental syntax of the generative trajectory of meaning.
Analysis of Air Distribution in a Double Tube Model Heat Exchanger System using Computational Fluid Dynamic (CFD)
Authors: Reniana Reniana , Darma Darma , Payung Paulus
Published: August 2024

The double-tube model heat exchanger has a construction of three tube cylinders arranged into one. This model of heat exchanger has a fairly simple construction, making it easier to manufacture and speeding up the manufacturing process. Computational Fluid Dynamics (CFD) is software that can be used to optimize the design and performance evaluation process as well as to speed up the process and minimize costs in tool development because it can represent phenomena that occur in a system. This research aims to analyze air distribution in a double tube model heat exchanger system using CFD analysis and to validate the analysis results with experiments. Based on the research results, a double tube model heat exchanger has been created with an average performance of output temperature and air velocity reaching 97.8oC and 10.4 m/s at a coconut shell fuel consumption of 0.24 kg/minute. The results of evaluating experimental data with simulations obtained RMSE values between 59.33 – 71.69, and MAPE values between 26.26 – 32.93. Meanwhile, the results of the Paired Sample T-Test show that there is no real difference between experimental data and simulation data with an R-value of 0.875 – 0.964. CFD analysis in this research can be used as a reference in the optimization process and development of heat exchangers, especially double-tube models. Keywords: CFD, Design, Double-Tube. Heat Exchanger, Simulation,
DESIGN AND VALIDITY OF AN E-ASSESSMENT FOUR TIER MULTIPLE CHOICE TO ASSESS SCIENCE LITERACY SKILLS OF SENIOR HIGH SCHOOL STUDENTS
Authors: Gunawan Maulina Suryati , Mufit Fatni
Published: August 2024

The low level of science literacy in sound and light waves is a problem in education, especially in physics learning. The low science literacy is caused by students' low understanding of concepts. Assessment instruments that specifically assess students' science literacy skills on the concept of sound and light waves are not widely available. This study aims to develop a valid four-level multiple choice e-assessment to assess students' science literacy skills on the concept of sound and light waves. This research is a development/design (R&D) research using the Plomp model. The developed e-assessment was validated by five experts. The data collection instruments used were interview sheets, self-evaluation sheets, and validation sheets. The results of the validity analysis showed that the e-assessment was in the valid category in terms of construction feasibility aspects, content feasibility aspects, display feasibility aspects, and language feasibility aspects. From the validity results with an average value of 0.94, it shows that the four-level multiple choice assessment to assess science literacy skills is declared valid and suitable for use.
COMMUNICATIVE COMPETENCE OF FILIPINO ENGLISH LANGUAGE TEACHERS: BASIS FOR A DEVELOPMENT PROGRAM
Authors: Esgrina Francisco Jr. Olermo
Published: August 2024

Ongoing professional development and implementation of supportive educational policies are important to address the linguistic challenges faced by non-native English language teachers (NNETs). These would enhance educational outcomes for students and improve the quality of basic education. This mixed-method exploration of the communicative competence of NNETs in Arakan, North Cotabato, Philippines, used descriptive-evaluative design, correlation, and In-Depth Interviews (IDIs). The findings showed that predominantly young female NNETs with diverse educational backgrounds had significant deficiencies in phonology and notable inadequacies in syntax, morphology, lexicon, and orthography despite their diligence in lesson preparation. Significant correlations were found between the subjects taught and lexicon proficiency, as well as the number and types of subjects handled and morphology competence. However, no significant correlations existed between their competence and educational attainment, job description, or seminar attendance. Additionally, significant differences were observed in orthographic proficiency by age and syntactic proficiency by gender, while civil status did not significantly impact competence levels. These findings underscore the urgent need for targeted professional development for NNETs. Specialized training or advanced English courses are essential to address linguistic shortcomings. With improved grammatical and linguistic skills, NNETs can enhance their pedagogical effectiveness and ensure the delivery of quality basic education.
The Contribution of Friday Bikers Community to the Dilemma of Busy Household and Active Church Participation
Authors: Koli Yovendi Mali ,   Fakultas Teologi, Universitas Sanata Dharma, Ambrosius Lolong , Lelono Martinus Joko ,   Faculty of Theology, University of Innsbruck,   Fakultas Teologi, Universitas Sanata Dharma
Published: August 2024

Since the Second Vatican Council, the Church has been concerned with the active participation of its members. However, work demands have made it increasingly difficult for the faithful to participate in Church activities. This study aims to find a pastoral style that can encourage active participation among the faithful despite their work demands. The research employed the Interpretative Phenomenological Analysis (IPA) and comparative method to study the Friday Bikers Community, a categorical community in Banteng Parish, Semarang Archdiocese. The study revealed that the Friday Bikers Community serves as a model for the church, effectively balancing the demands of work and active participation in ecclesial activities. The Friday Bikers Community integrates churching in a genuine way, focusing on communio, relationships, inner dispositions, and existential limitations of its members.
Naim Stifan Ateek's Palestinian Liberation Theology for The Israel-Palestine Conflict
Authors: Febriantoro Valentinus Fio Milinio ,   Faculty of Theology, Universitas Sanata Dharma, Wibowo Thomas Lasmono , Prakosa JB. Heru ,   Faculty of Theology, Universitas Sanata Dharma
Published: August 2024

Palestine is a country where the population is around 4-5 million. The current Christian population in Palestine is around 6 percent of the total population. These are religiously oppressed people who are affected by the political turmoil of Israel and Palestine. This community is in dire need of a correct and adequate understanding of the theological meaning of the Palestinian experience of suffering in relation to Israel. The Bible has been misused to legitimize political interests. Naim Ateek believes that they are suffering and hopes that the Church will be able to build and explain a theology of liberation for Palestinian Christians. With the method of literature study and comprehensive reading, it is found that Naim Ateek makes a new hermeneutic so that God is not understood as a Primitive and Exclusive God as described by Israel who takes sides and discriminates, but a Universal and Inclusive God to realize justice in the spirit of compassion and peace so that it can show the harmony of God for the peace of the Palestinians and Israelis.
Pension Fund and a Faith that Promotes Justice in Indonesian Context
Authors: Hinganaday Rafael Mathando ,   Yadapen Catholic Pensiun Fund
Published: August 2024

According to the statistics, most of elderly people in Indonesia depend on younger generation to fulfil their daily needs. Many of them still need to work. Pension fund also gives little contribution for the elderly who previously worked at institutions. The level of knowledge on pension fund among Indonesians is still low, which also contributes on low participation in pension fund. Within this context, the Catholic Church in Indonesia implements concretely a faith that promotes justice. This is a literature review which aims to provide a deeper understanding on how Catholic pension fund institutions have implemented Catholic Social Teaching in Indonesian context, especially in the terms of “a faith that promotes justice”. This research uses pastoral circle scheme, which was popularized by Joe Holland and Peter Henriot, as a method for theologically reflecting the role of Catholic pension fund institutions in Indonesia. For this purpose, the author also learns from documents of the Church and the Society of Jesus, which express the slogan “a faith that promotes justice”. From the research, the author finds that only Laborem Exercens mentions clearly about people’s right to receive pension, when, at the same time, the Church also urges care for old people. Since this minimum regard for pension fund does not reflect real faith implementation of the Catholic Church related to social justice practices, especially care for old people and pensioners, Catholic pension fund institutions in Indonesia play a great role in sounding real concern of the Catholic Church.
Structure of time perspective in combatants with amputated limbs
Authors: Nikishina VB , Petrash EA , Yunina-Pakulova NYu , Lukyanov ES
Published: August 2024

The relevance of the reported study results from the need to clearly define the target of psychological impact in combatants with amputated limbs. The time perspective being an integral characteristic ensures the life experience integrity: all life events are intertwined within the boundaries of the past, present and future. The study was aimed to assess the time perspective structure in combatants with amputated limbs. The sample consisted of 78 males aged 20–53 years, who had combat experience and underwent treatment or rehabilitation after getting injured. The study involved the use of the Mississippi Scale for Combat-Related PostTraumatic Stress Disorder, Zimbardo Time Perspective Inventory, method for event-based reconstruction of a person’s time perspective by V.B. Nikishina and E.A. Petrash, SR-45 method by P.I. Yunatskevich, infantilism inventory by A.A. Seregin. The factor structure of time perspective in combatants with amputated upper limbs includes the factor of non-reflexive future, factor of limited time perspective, and the situational and behavioral risk factor. In cases of amputated lower limbs, the situational future factor, past orientation factor, and situational and behavioral risk factor are represented. In cases of no amputated limbs, the combatants’ time perspective structure includes the factor of reflexive future perspective, factor of limited present fatalistic, and past orientation factor.
Реконвалесценция метафизики
Authors: Василевский Валентин
Published: August 2024

Цель работы – разрешить трудную проблему сознания [Чалмерс], определяя Сознание и Разум как качественно разные системы: отделив субстрат, на котором работает сознание от субстрата, на котором работает разум. В работе представлена гипотеза о том, как может существовать мир идей, не детерминированный физическим миром, но базирующийся на нем. Метафизика как абстрактная экосистема разума, используемая в целях исследования мира, развития и преодоления пределов.
ГЕОМЕТРИЗИРОВАННАЯ ФИЗИКА ВАКУУМА. ЧАСТЬ 6: ИЕРАРХИЧЕСКАЯ КОСМОЛОГИЧЕСКАЯ МОДЕЛЬ
Authors: БатановГаухман Михаил
Published: August 2024

Данная статья является шестой частью научного проекта под общим названием «Геометризированная физика вакуума на основе Алгебры сигнатур» [1, 2, 3, 4, 5]. В этой статье предложена иерархическая космологическая модель, которая разработана на основе решения расширенного вакуумного уравнения Эйнштейна с бесконечным числом лямбда членов. Более подробно рассмотрено решение упрощенного вакуумного уравнения с десятью лямбда членами. В результате получена метрико-динамическая модель дискретной иерархической последовательности стабильных сферических вакуумных образований («корпускул»), которые вложены друг в друга подобно матрешкам. Из этой иерархической последовательности выделен и боле подробно рассмотрен уровень элементарных частиц. Использование методов и математического аппарата дифференциальной геометрии Римана и Алгебры сигнатур позволении получить метрико-динамические модели всех элементов Стандартной модели элементарных частиц: «кварков», «лептонов», «нуклонов», «мезонов», «фотонов», «глюонов», а также «атома» водорода и «атома» гелия. Высказано предположение, что аналогичным образом могут быть построены метрико-динамические модели стабильных вакуумных образований («корпускул») «звездно-планетарного» «галактического» и «Вселенского» уровней. Показана связь между расширенной общей теорией относительности и квантовой механикой. В конце статьи рассмотрены достоинства и недостатки предложенной иерархическая космологическая модели и обозначены метафизические предпосылки для разрешения возникших проблем.
The Effectiveness of Tactical Methods of Logical Influence and Tactical Combinations during Interrogation Using Video Conferencing Systems in the Russian Federation
Authors: Bondarenko Yuri A. ,   Kuban State University, Balugina Tatiana S. , Malyutin Mikhail P ,   Kuban State University,   Kuban State University
Published: August 2024

The article considers the applied issues of tactical and forensic support of interrogation using video conferencing tools in relation to the use of tactical techniques of logical influence on the interrogated and common tactical combinations. The authors conclude that the techniques of logical influence are more effective in the remote format of interrogation compared with tactical techniques based solely on the emotional impact on the interrogated. Regarding the effectiveness of tactical interrogation combinations, the following pattern was revealed: the lower the proportion in the combination of emotional impact techniques, the more likely it is to achieve the planned goal of conducting it in a video conference call. The authors recommend that investigators use means of active involvement in communication during the use of video conferencing systems: you can ask the interrogated person to fix a schematic diagram of the place of the event, make and comment on a written description of the situation of the event under investigation, or perform other actions that encourage him to be active at the location. Practically useful in the format of remote interrogation is the combination of one tactical technique with the performance of the interrogated action or explanation of related phenomena aimed at activating his memory, and two or three techniques without active actions and within the framework of the phenomena included in the subject of interrogation.
Determinant Factors Influencing the Reuse Practice of Heritage Shop Houses in the World Heritage City Melaka Core Zone
Authors: Ab Rashid Nor Syahila ,   Universiti Sains Islam Malaysia, Malaysia, Heath Tim ,   University of Nottingham, United Kingdom
Published: August 2024

Rapid economic development and restructuring have an impact on the existence of more old buildings in large cities. Most of these buildings represent different eras and typologies. Like a shophouse in Southeast Asia that has its uniqueness, is a very important heritage. The desire to carry out research related to the reuse of shophouses arises from the condition of some of the city's assets that are abandoned and dilapidated. However, the maintenance of the shophouse with the original function may not be appropriate as the nature of use may change over time according to needs. Therefore, the practice of re-use is suggested to ensure that the building in question continues to be preserved and also to prevent obsolescence from being used as a justification for demolition. The objective of this research is to identify the most popular reuse options and the determining factors that influence the reuse of heritage shophouses in the Melaka Core Zone of the World Heritage City. This research uses survey (quantitative) and observation (qualitative) methods to gather information. Microsoft Excel and NVivo software were used to assist in the analysis of the collected data. Research findings show that cafes and restaurants are the most popular options for partial storefront repurposing, while hotels and motels are the most popular options for full storefront repurposing in this area. Legal provisions, tourism demand, inscription demand, profit, obsolete original function, building vacancy, and accessibility are identified as determining factors in the reuse practice. A deep understanding of the reuse process has the potential to be the basis of better policy formation to ensure that shops in this area remain actively functioning. The preservation of this building is important to maintain Melaka's recognition in the UNESCO World Heritage Site list on an ongoing basis.
“Romantic” Poprishchin: History of the Concept of N.V. Gogol the Story “Diary of a Madman”. Part 2
Authors: Vinogradov Igor ,   A.M. Gorky Institute of World Literature RAS
Published: August 2024

The paper deals with the idea of N.V. Gogol`s “St. Petersburg” story “Notes of a Madman”. Numerous reminiscences of images from world literature, journalism and fiction of that period are examined in detail. Long-term studiing on the poetics of Gogol’s story are summarized. The connection between “Notes of a Madman” and the poem “Dead Souls” and “Reflections on the Divine Liturgy” is established. Gogol’s polemic with European romanticism in is explored circumstantially. The article is a continuation, based on new material, of a research work begun in 2022 – “German romantic V.G. Wackenroder and the 20th century: artistic foresight N.V. Gogol” (published in the collection of the IWL RAS “Literary Process in Russia in the 18th–19th centuries. Secular and Spiritual literature”). An attempt has been made to present a holistic concept of the work and a wide range of fruitful research thoughts in its interpretation. The work consists of the fifteen sections: 1. Problems of interpretation of the story; 2. Background and history of the creation of “Notes of a Madman”; 3. “Soulful City” “Notes...”; 4. Idleness, bribery, threat of “scolding”; 5. Diktat of fashion, red tape; 6. Neglect of spiritual growth; 7. Vanity and the possibility of repentance; 8. From “Notes of a Madman” to “Dead Souls” and “Reflections on the Divine Liturgy”; 9. Pseudoculture; 10. “Donquixoticism”; 11. Cervantes and Ariosto; 12. The circle of romanticism: poetry, politics, philosophy, mysticism; 13. “Notes of a Madman” and romantic madness; 14. Poprishchin and music; 15. “Popular theology”. This publication presents the final four sections. The previous eleven were published in issue 3(65) of the magazine for 2024.
Inflation-balance of trade nexus in Nigeria: The impact of exchange rate pass-through
Authors: Opene-Terry Josephine Obiageli , Uzoechina Benedict Ikemefuna , Okeyika Kenechukwu Okezie , Ezenwobi Ngozi Florence , Oladipo Abimbola A. , Okafor Vincent Chuks
Published: August 2024

The relationship between exchange rate (EXR) and foreign trade (FT) in Nigeria has been a contentious issue since Nigeria’s independence in 1960. This study investigated the link between exchange rate and foreign trade through the prism of exchange rate pass-through (EXRPT) to domestic prices, utilizing monthly data from 2011 to 2022. The study was built on two models—the base and main models, respectively. Employing the VAR technique and its Vector Error Correction Model (VECM) extension, the paper found that EXRPT to consumer prices is incomplete in the short run, but its effect was found to be higher on imports than on consumer prices. It follows that the impact of EXRPT diminishes along the price chain. Results from the main model indicate that the impact of domestic prices on balance of trade was found to be negative with an elasticity of −0.437541 and is also statistically significant, thus confirming the Marshal-Lenner condition. The Marshal-Lenner condition and findings of this study provide evidence that depreciating exchange rate is not recommended for an import-inelastic country like Nigeria.
Why do multinational enterprises in the auto parts industry set up in Morocco?
Authors: Alfaro-Moreno Karina , Rivera-Galicia Luis F. , Bakkali Imad
Published: August 2024

The Moroccan economy has undergone significant structural changes since the 1980s. Attracting Foreign Direct Investment (FDI) has been a key strategy for the country’s economic growth and development, particularly in some specific high value-added sectors, such as the automotive supply industry. This paper uses the results of a survey to examine the reasons why multinational enterprises (MNEs) in the automotive supply sector set up in Morocco. Our findings show that proximity to Europe and labor costs and skills are the most important considerations for investing in this sector in Morocco. However, some institutional issues are still of concern to these MNEs.
The value of digital preservation in reviving colonial cultural heritage in Egypt
Authors: Sobaih Abu Elnasr E. , Naguib Shaimaa M. , Ibrahim Amal H. M.
Published: August 2024

This study explores the potential of digital preservation in the documentation of colonial cultural heritage in Egypt. It also explores the stories behind historical wars to revive these sites and attract different segments of visitors. Documentation of these sites should enhance Egyptian colonial cultural heritage sites, which include battlefields, war memorials, commanders’ palaces, assassination and murder spots, cemeteries, and mausoleums. The purpose of this study was fulfilled through field visits supplemented with in-depth interviews with experts on colonial heritage sites in Egypt. The findings showed that technology could play a key role in implementing the storytelling documentation and interpretation of colonial history and its relevant events at the Egyptian sites. However, to date, these sites have not made the best use of technology for digital preservation and documentation due to many challenges. The study recommends that decision-makers should integrate technological innovation, which can revitalize the communities built on the ruins of colonialism and revive the heritage of popular resistance. Technological innovation could be implemented not only in digital preservation and documentation but also in service and marketing of these colonial heritage sites.
Quality, Performance, Excellence: The Harmonious Organizational Triad
Authors: Barbu Andreea , Scarlat Cezar
Published: August 2024

The main purpose of this paper is to introduce a conceptual model of the triad Quality - Performance - Excellence (QPE); call it the Harmonious Organizational Triad. The method is qualitative, based on literature survey (secondary research), analyzing the interdependencies between these pairs of concepts (quality-performance, quality-excellence, and performance-excellence) within organizations. In this regard, an analysis of the existing literature on the concepts of quality, performance and excellence was carried out, highlighting relevant theories, models, and approaches to studying these concepts. Several studies exploring the interactions between quality and performance, quality and excellence, and performance and excellence were identified. The objective was to identify how each two concepts (i.e., quality and performance; quality and excellence; performance and excellence) are interconnected in an organizational context. Based on the literature analysis and the relationships identified between the concepts, a conceptual triadic model (QPE Triad) was developed. The QPE Triad illustrates the connections between the three concepts and their interdependencies. The implications are important for both scholars and practitioners – managers of organizations active in various industries – either goods manufacturing or service providers.
OPTIMALISASI KUNJUNGAN POSYANDU BALITA MELALUI KELAS IBU BALITA DI WILAYAH KERJA PUSKESMAS PEGAMBIRAN KELURAHAN GATES NAN XX KOTA PADANG
Authors: Desmawati Desmawati , Agus Meilinda , Fergita Agnestya Nurul , Rahmawati Mimi , Primasari Nissa , Fadhilah Syifa , Marintan Trisnanda
Published: August 2024

Pos Pelayanan Terpadu (Posyandu) merupakan lembaga kemasyarakatan dalam rangka memberdayakan dan mempermudah masyarakat untuk memperoleh pelayanan kesehatan. Salah satu kegiatan posyandu adalah monitoring pertumbuhan dan perkembangan bayi dan balita. Upaya meningkatkan kunjungan ke posyandu dengan pengadaan kelas ibu bayi dan balita, yang menjadi tempat berdiskusi, tukar pendapat dan pengalaman akan pelayanan kesehatan, gizi dan stimulasi pertumbuhan dan perkembangannya dibimbing oleh fasilitator dengan menggunakan buku KIA. Kegiatan ini bertujuan untuk meningkatkan kesadaran masyarakat RT 01 RW 01 kelurahan Gates Nan XX tentang pentingnya memantau tumbuh kembang bayi dan balita. Metode yang digunakan adalah survey analitis dengan melakukan pengumpulan data pada masyarakat, menganalisa masalah, menentukan prioritas masalah, membuat plan of action dengan metode scoring USG, melakukan intervensi kelas ibu balita dengan media buku KIA dan Audio Visual dan evaluasi kegiatan. Hasil pendataan kesehatan yang tim pengabdi lakukan sebelumnya di RT.01 RW.01 Kelurahan Gates Nan XX didapatkan hasil bahwa jumlah bayi usia 29 hari-12 bulan sebanyak 2 orang dengan riwayat melakukan penimbangan tiap tiga bulan sebanyak 1 orang (50%), sedangkan jumlah penduduk balita usia 1-5 tahun sebanyak 9 orang, dengan riwayat tidak melakukan penimbangan dalam tiga bulan terakhir sebanyak 7 orang (78%). Kesimpulan dari kegiatan ini adalah ibu balita berkomitmen akan melakukan pemantauan tumbuh kembang balita di posyandu serta ikut aktif dalam mengikuti kelas ibu balita setelah dilakukan intervensi pemberdayaan ibu.
PENGOLAHAN PRODUK JAHE MERAH SIAP SEDUH: PENDEKATAN INOVATIF DALAM PEMBERDAYAAN KADER POSYANDU DAN PKK DI KELURAHAN LIMAU MANIH SELATAN KOTA PADANG
Authors: Srangenge Yoneta , Hefni Dira , Shiami Beba , Lucida Henny
Published: August 2024

Fenomena swamedikasi yang tinggi di Indonesia memerlukan intervensi untuk mengurangi risiko kesalahan penggunaan obat. Tujuan kegiatan adalah untuk memberdayakan kader Posyandu dan PKK di Kelurahan Limau Manih Selatan melalui pelatihan pengolahan jahe merah menjadi minuman siap seduh, sehingga mereka dapat meningkatkan kesehatan masyarakat dan ekonomi lokal. Kegiatan ini dilaksanakan di Posyandu Perumahan Griya Permai, Kelurahan Limau Manih Selatan, Padang. Metode yang digunakan meliputi ceramah, demonstrasi, praktik langsung, dan diskusi. Materi pelatihan mencakup penggunaan obat rasional berbahan herbal, pengolahan jahe merah, dan cara menghasilkan produk yang berkualitas. Peserta yang terdiri dari kader Posyandu, PKK, dan masyarakat umum, dipilih berdasarkan peran mereka dalam komunitas. Pelaksanaan kegiatan menghasilkan peningkatan signifikan dalam pengetahuan dan keterampilan dalam pengolahan jahe merah dan penggunaan obat herbal secara rasional pada 43 peserta yang berpartisipasi. Para peserta juga berhasil memproduksi minuman jahe merah siap seduh yang memenuhi standar kualitas. Selain meningkatkan pemahaman tentang penggunaan obat tradisional yang aman, pelatihan ini juga mengubah persepsi masyarakat mengenai pengobatan herbal. Peserta menunjukkan antusiasme tinggi dan memberikan umpan balik positif, berharap adanya pelatihan lanjutan di masa depan. Dapat disimpulkan bahwa pelatihan ini efektif dalam memberdayakan kader kesehatan dan meningkatkan pengetahuan serta keterampilan mereka dalam pengolahan obat tradisional. Untuk keberlanjutan, direkomendasikan pemantauan berkelanjutan dan pengembangan bisnis lokal dari produk jahe merah siap seduh. Pihak kelurahan dan pemerintah setempat diharapkan mendukung program ini untuk memperluas dampaknya, yang pada akhirnya dapat meningkatkan kesehatan masyarakat dan mendorong pembangunan ekonomi lokal yang berkelanjutan.
MEMBANGUN KEMANDIRIAN EKONOMI KELUARGA PEMULUNG TPA AIR DINGIN KOTA PADANG MELALUI PELATIHAN KETERAMPILAN PEMANFAATAN SAMPAH PLASTIK MENJADI KREASI YANG BERGUNA
Authors: Wati Wati , Rahmania Meri , Syafii Syafii , Harini Gustia
Published: August 2024

Penanganan sampah menjadi hal yang krusial, untuk itu perlu menjaga kebersihan lingkungan, dan mencegah pencemaran lingkungan. Pengolahan sampah yang didaur ulang dapat bernilai ekonomis sehingga meningkatkan kemandirian ekonomi masyarakat. Tujuan kegiatan ini adalah untuk mengurangi dampak limbah plastik dengan memanfaatkannya secara kreatif untuk meningkatkan nilai tambah. Kegiatan ini telah dilaksanakan di Tempat Pembuangan Akhir (TPA) Air Dingin Lubuk Minturun, Kota Padang. Kegiatan ini melibatkan 30 peserta, yang mayoritas adalah ibu-ibu pemulung. Lokasi kegiatan berada di rumah Bapak RT setempat. Pada kegiatan ini, peserta diberikan pelatihan tentang keterampilan memanfaatkan sampah plastik. Tim pelaksana kegiatan menjelaskan cara menggunakan alat-alat seperti gunting, pisau carter, isolasi, dan kabel. Demonstrasi praktis diberikan agar peserta memahami dengan baik bagaimana mengolah plastik menjadi kreasi yang berguna. Selama kegiatan, peserta berkreasi dari plastik bekas dengan kebebasan dan berkolaborasi dalam berbagai ide. Diskusi tentang pentingnya kesadaran lingkungan dan edukasi tentang daur ulang juga terjadi. Peserta diajak untuk memahami dampak negatif limbah plastik dan bagaimana mereka dapat berkontribusi dalam mengurangi masalah ini. Tim pelaksana kegiatan juga melakukan pengukuran terkait dampak kegiatan. Secara kuantitatif, mereka memantau jumlah plastik yang berhasil didaur ulang dan menghitung potensi pengurangan limbah plastik. Secara kualitatif, mereka mencatat perubahan sikap peserta terhadap pengelolaan limbah dan kesadaran lingkungan. Setelah kegiatan selesai, evaluasi dilakukan untuk perbaikan di masa mendatang. Diskusi tentang apa yang berhasil dan apa yang perlu diperbaiki membantu mengidentifikasi peluang perbaikan.
Fatores fisiológicos e patológicos com impacto na qualidade do sono no idoso: uma revisão de literatura
Authors: Albuquerque Larissa Belon , Cataldo Neto Alfredo
Published: August 2024

Introdução: A qualidade do sono em idosos emerge como um tema de suma relevância, respaldado por dados estatísticos alarmantes. Cerca de 50% da população idosa relata distúrbios do sono, evidenciando a prevalência significativa desses problemas nessa faixa etária. À medida que a idade avança, observa-se um aumento progressivo na incidência de distúrbios do sono, sinalizando a urgência de abordar os fatores subjacentes que contribuem para essa deterioração. Objetivo: Investigar a qualidade do sono em idosos, analisando os fatores fisiológicos e patológicos que influenciam esse fenômeno. Metodologia: Trata-se de uma revisão de literatura com base na análise de artigos científicos publicados no PubMed, Scopus, Scielo, Google Acadêmico e BVS no período de 2019 a 2023. Resultados: Após a conclusão da fase de coleta de dados, foram identificados 6 artigos relevantes para compor a análise do tema proposto. Discussão: Observou-se uma prevalência significativa de distúrbios do sono, aproximadamente 50% na população idosa. As mudanças fisiológicas, como no ritmo circadiano e na produção de melatonina, e as condições patológicas, como apneia obstrutiva do sono e insônia, influenciam adversamente. Intervenções personalizadas e políticas de saúde pública são necessárias para melhorar a qualidade do sono dos idosos, visando impactar positivamente a sua saúde geral. Conclusão: Destaca-se a necessidade urgente de abordagens específicas para melhorar a qualidade do sono nos idosos, visando promover um envelhecimento saudável e abordar a prevalência significativa de distúrbios do sono nesta população.
A Hard Pill to Swallow: Privacy Implications of Direct-to-Consumer Prescription Drug Services
Authors: Challapally Varsha
Published: August 2024

This case note discusses the emergence and popularity of direct-to-consumer prescription drug services and evaluates their privacy implications on consumers. Minimal regulation exists regarding direct-to-consumer prescription drug services, and patient privacy and data protection laws are also limited. Proponents of these services claim that they allow certain prescription drugs to be available to consumers without the hassle and logistics of health insurance and making and attending medical appointments, effectively empowering individuals to take control of their own health. Alternatively, critics claim that direct-to-consumer prescription drug services are operated by private companies that are not always required to be compliant with patient health privacy and laws, creating the potential for disastrous effects on sensitive health information. This case note evaluates the popularity of these services, analyzes how the way direct-to-consumer prescription drug services are marketed may have an impact on consumer privacy, current and pending litigation surrounding data breaches and privacy issues, and their overarching implications on patient and consumer privacy.
The Game-Changer: Legal Issues Surrounding Wearable Technology in Sports
Authors: Vande Berg Jack
Published: August 2024

Athletes and teams are always seeking to gain a competitive edge, and the emergence of wearable technology has provided them with biometric data that provides new insights into performance. The market for wearable technology has been growing at a rapid pace in recent years and is projected to continue on an upward trajectory through the end of the decade. Governing bodies of sport at a professional and amateur level have adapted regulations for the use of this new technology and the data it produces. This article provides an overview of these current regulations, and then discusses three pressing legal issues. First, the implications of state and federal data privacy laws on wearable technology and concerns over data breaches are addressed. Next, biometric data’s impact on the recently legalized sports betting market is discussed. The article concludes with an analysis of who owns the biometric data produced by wearable technology, and the importance of why athletes, not teams or leagues, should own it.