bluuebunny/crossref_metadata_2025 huggingface dataset:
The Synthesis of 2,6-Pyridinedicarboxylic Acid Modified Porous Polypyrrole Electrodes and Its Energy Storage Application
Authors: Arvas Melih Besir , Yazar Sibel , Sahin Yucel
Published: November 2022

The well-designed porous polypyrrole/dicarboxylic acid (PPy/DCA) (0.02) electrodes were successfully synthesized by hydrothermal method. In this study, the interesting structural properties of the synthesized electrodes were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TG-DTA), Brunauer–Emmett–Teller (BET) and scanning electron microscopy (SEM). The scanning electron microscopy results showed that a large number of random pores were formed on the electrode surface during the polymerization of pyrrole. The galvanostatic charge-discharge measurements exhibited a specific capacity of 854.2 F.g−1 at 2.7 A.g−1 with an energy density of 884.4 Wh.kg−1. Further, the supercapacitor electrode showed a good cycling test (87.3%) after 4000 cycles at a current density of 10.0 A.g−1 and wide operating voltage (3.0 V). Our studies suggest that 2,6-pyridinedicarboxylic acid doped-polypyrrole electrodes with interesting structure and easy synthesized method are promising candidates for high-performance supercapacitor devices.
Study on Evolution Law and the Mechanical Mechanism of Strong Mine Tremors in a Deep Coal Mine
Authors: Wang Chao , Wang Man , Gong Siyuan , Zou Junpeng , Wu Kunbo
Published: November 2022

Strong mine tremor occurs frequently in deep mines, which have brought great hidden dangers to the safety of mine production. This paper takes panel 63/06 in No. 6 mining area of Dongtan coal mine as the research background, through geological survey, laboratory test, theoretical analysis, numerical simulation, on‐site microseismic monitoring, the seismic evolution law and its mechanical mechanism, etc., and the conclusions are as follows: (1) there are three sets of key layer groups between the surface of the panel 63/06 and the coal seam, among which there is a large amount of energy in the thick Jurassic red layer and the lower key layer, which provides an energy basis for the red‐bed to break and generate strong mine tremors; (2) on the plane, most of the strong tremors occurred in front of the mining position of the working face and tended to transfer to the side of the gob, and longitudinal, high‐energy mine tremors are mainly distributed in high‐level red sandstone; (3) the release location of high‐energy mining earthquakes does not match the location of microseismic accumulation, indicating that there is no elastic energy accumulation in the lower surrounding rock before the strong mining earthquake occurs, and it highlights the characteristics of structural occlusal instability rather than energy abrupt instability in the rupture of the red and thick sandstone; and (4) the Dongtan red‐bed type strong mine tremors have a large focal rupture radius, a long rupture duration, a small corner frequency, and a weak initial P wave, and the characteristics of low stress drop and no catastrophic nature indicate that the thick and low‐strength red‐bed is prone to large‐scale fractures, which should belong to the structural instability type mine shock dominated by tensile fracture.
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Authors: Mohkam Milad , Golkar Nasim , Nabavizadeh Seyed Hesamodin , Esmaeilzadeh Hossein , Berenjian Aydin , Ghahramani Zahra , Gholami Ahmad , Alyasin Soheila
Published: November 2022

ADAM33 is a zinc-dependent metalloprotease of the ADAM family, which plays a vital biological role as an activator of Th2 cytokines and growth factors. Moreover, this protein is crucial for the normal development of the lung in the fetus two months after gestation leading to determining lung functions all over life. In this regard, mutations in ADAM33 have been linked with asthma risk factors. Consequently, identifying ADAM33 pathogenic nonsynonymous single-nucleotide polymorphisms (nsSNPs) can be very important in asthma treatment. In the present study, 1055 nsSNPs of human ADAM33 were analyzed using biocomputational software, 31 of which were found to be detrimental mutations. Precise structural and stability analysis revealed D219V, C669G, and C606S as the most destabilizing SNPs. Furthermore, MD simulations disclosed higher overall fluctuation and alteration in intramolecular interactions compared with the wild-type structure. Overall, the results suggest D219V, C669G, and C606S detrimental mutations as a starting point for further case-control studies on the ADAM33 protein as well as an essential source for future targeted mechanisms.
Research on the Importance of Intelligent Equipment Support Capability Indexes Based on the GQFD-BP Neural Network
Authors: Li Lei , Jiang Xiangzheng , Liu Tielin , Meng Qingbin , Liu Yue , Yin Shizhuang
Published: November 2022

The importance of the equipment support capability index is the premise and foundation of equipment support construction and is the logical starting point for carrying out related research. Determining the importance of equipment support capability indicators can guide and lead the improvement of support capability and promote the performance of equipment support. Aiming at the problems of high subjectivity and low reliability in the current method for determining the importance of the capability index, this paper proposes a gray relational quality function expansion method based on the GQFD-BP neural network. Through the process of determining the task index and the capability index, constructing an expert preference model, establishing the gray comprehensive correlation matrix, and building a house of quality, the importance of the intelligent equipment support capability index is determined, and a theoretical basis for the construction and application of intelligent equipment support capabilities is provided.
Interleukin-27 Ameliorates Atherosclerosis in ApoE-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance
Authors: Xu Wenbin , Zhu Ruirui , Zhu Zhengfeng , Yu Kunwu , Wang Yue , Ding Yan , Yu Jian , Tang Hongxia , Zeng Qiutang , Zhong Yucheng
Published: November 2022

Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. Recent evidence indicated that interleukin (IL)-27 showed pleiotropic properties in immune diseases. However, precise mechanisms of IL-27, especially in atherosclerosis remains unknown. In our research, we examined the influence of the administration of IL-27 and an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both the initiation and the progression of atherosclerosis. In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP+ or Foxp3+) in the spleen and peripheral blood was increased. Meanwhile, the number of T helper 1 (Th1) and T helper 17 (Th17) cells was decreased. In the peripheral blood plasma, TGF-β and IL-10 expression were increased, while the levels of IFN-γ and IL-17 were reduced. As for lesions, the mRNA expression of Foxp3, TGF-β, and IL-10 was increased, while that of IFN-γ and IL-17 was reduced. In the anti-IL-27p28 antibody groups, we obtained opposite results. We also observed that DCs treated with IL-27 display a tolerogenic phenotype and that IL-27–treated tolerogenic DCs (tDCs) are likely to play a protective role during atherosclerosis. Our study indicates that IL-27 or adoptive transfer of IL-27 loaded tDCs may be a new therapeutic approach in atherosclerosis.
Study and Evaluation of Quality of Services in Mobile Internet Protocol v6 Using IEEE802.11e
Authors: Alwer Abdulkader O. , Rasheed Jawad , Abu-Mahfouz Adnan M. , Shams Parvaneh
Published: November 2022

Mobile Internet Protocol v6 (MIPv6) is a protocol that allows a mobile node (MN) to transparently maintain connections while moving from one subnet to another. Using the route optimization (RO) method in MIPv6 gives optimized routing and helps avoid triangular routing. In real-time applications such as video conference applications, quality of service (QoS) issues will increase especially in the handover process between subnets. This study investigates the performance of MIPv6 handover in IEEE802.11e standard in wireless environments. The investigation considers that handover for the MN moves between 2 home agents (HA). The system model’s fundamental performance limits are measured by packet delay variation, HA binding delay, and wireless local area network (WLAN) media access delay analysis metrics in video conference applications. According to the results of real-time simulations, network performance during the handover process can be effectively improved as the packet lost during handover decreased significantly from 43% in IEEE802.11b distributed coordination function (DCF) to 36% in IEEE802.11e hybrid coordination function (HCF). Furthermore, experimental results prove that IEEE802.11e connects to new HA roughly 20% quicker than IEEE802.11b, and IEEE802.11b has 100 times more time delay than IEEE802.11e. In addition to this, the WLAN media access delay of IEEE802.11b often reaches 0.00011 s as compared to 0.000005 s of IEEE802.11e. Thus, it is evident that the performance of IEEE802.11e in terms of packet delay variation, HA binding delay, and WLAN media access delay is better than IEEE802.11b. Likewise, it is noted that network speed during the handover process in IEEE802.11e can be considerably improved in a MIPv6 scenario.
Determination of the Height of Overburden Water-Conducting Fracture Zone in 215102 Working Face of Yue Nan Coal Mine
Authors: Chen Xiangjun , Huang Zhen , Wang Lin , Dong Xiaozhen , Cui Pengfei
Published: November 2022

In order to extract gas accurately in Yue Nan coal mine and prevent gas over limit and gas accidents, a combination of theoretical analysis and numerical simulation was used to investigate the height of the overburden caving zone and fracture zone in the working face, using 215102 working face as the engineering background. The results show three key strata in the 215102 working face, namely siltstone, sandy mudstone, and sandy mudstone. The empirical formula’s calculation results are in good accord with the findings of the theoretical analysis, which indicates that the height of the water-conducting fracture zone created by mining in 215102’s working face is 87.35 m. The plastic zone, stress distribution and displacement variation of the model overburden of the working face were analyzed separately in the numerical simulation. The results of the plastic zone simulation show that the caving zone’s maximum height is about 15.96 m, and the fracture zone’s maximum height is approximately 82.39 m. The stress distribution shows that the caving zone’s greatest height is around 13.65 m, while the fracture zone’s maximum height is roughly 77.24 m. The amount of overburden subsidence proves that the caving zone’s maximum height of about 10.08 m, and the fracture zone’s maximum height of approximately 82.69 m. The height of the overburden caving zone and fracture zone of 215102 working face are ultimately found to be 14.02 m and 76.42 m, respectively, based on theoretical analysis, empirical formula calculation, and numerical simulation findings.
Study of Graphene Networks and Line Graph of Graphene Networks via NM‐Polynomial and Topological Indices
Authors: Wu Jie , Nazeer Saima , Ahmed Iftikhar , Yasmin Farkhanda
Published: November 2022

The topological invariants are related to the molecular graph of the chemical structure and are numerical numbers that help us to understand the topology of the concerned chemical structure. With the help of these numbers, many properties of graphene can be guessed without preforming any experiment. Huge amount of calculations are required to obtain topological invariants for graphene, but by applying basic calculus roles, neighborhood M ‐polynomial of graphene gives its indices. The aim of this work is to compute neighborhood degree‐dependent indices for the graph of graphene and the line graph of subdivision graph of graphene. Firstly, we establish neighborhood M‐polynomial of these families of graphs, and then, by applying basic calculus, we obtain several neighborhood degree‐dependent indices. Our results play an important role to understand graphene and enhance its abilities.
Atypical Manifestation of VZV Infection in a Vaccinated Immunocompetent Adult
Authors: Bhojwani Deesha , Zakarya Mohamed , Abu Khalaf Suha
Published: November 2022

Introduction. Aseptic meningitis can occur from different types of infections of which viral etiologies are the most common. Varicella zoster virus (VZV) nowadays is considered a familiar entity of aseptic meningitis. However, it is usually reported in immunocompromised patients. For cases of VZV meningitis that are observed, a rash has been noted before the onset of meningitis or sometimes after it. Clinical Case. We present an uncommon case of VZV meningitis in an 18-year-old immunocompetent male who did not have a rash on presentation and did not develop one during his course either. Cerebrospinal fluid showed lymphocyte-predominant leukocytosis and elevated protein with normal glucose suggestive of aseptic meningitis. Cerebrospinal fluid polymerase chain reaction (CSF PCR) was positive for VZV; cerebrospinal fluid cultures and blood cultures were negative. The patient had complete resolution of symptoms with no complications on intravenous acyclovir therapy and was discharged home on oral valacyclovir therapy. Conclusion. It is important to consider varicella zoster virus as an etiology of aseptic meningitis as clinical presentation can be without a vesicular rash and in immunocompetent patients.
Multiple Imaging and Surgical Characteristics in Cardiac Metastasis from Undifferentiated Uterine Sarcoma
Authors: Sasahara Hiroka , Yatsu Shoichiro , Wada Hideki , Sai Eiryu , Moriya Soshi , Miyazaki Suguru , Kajimoto Kan , Ogita Manabu , Suwa Satoru
Published: November 2022

Although cardiac metastasis of malignant tumors has often been reported, undifferentiated uterine sarcoma (UUS) is a rare and aggressive uterine tumor. Thus, little is known of the UUS as a primary site of cardiac metastasis. We report a case of a 66-year-old woman, with a history of uterine myoma for 30 years, who was hospitalized with a large uterine tumor and cardiac masses. Although we investigated cardiac masses using imaging modalities, such as ultrasound, cardiac computer tomography, and magnetic resonance imaging, it was challenging to determine the masses as metastasis or thrombi. Cardiac masses were removed by surgery to assess the tissue characteristics and were later identified as tumors due to their appearance. Then, pathological findings revealed that UUS spreads to the right ventricle. We attempted chemotherapy after surgery; however, the disease progressed very quickly and the patient died on the 49th day of admission. In this report, we described the case of a patient with a difficult diagnosis and rapid disease progression of cardiac metastasis from UUS.
[Retracted] Multifunctional Drug‐Loaded Phase‐Change Nanoparticles Inhibit the Epithelial‐Mesenchymal Transition of Hepatocellular Carcinoma by Affecting the Activity of Activated Hepatic Stellate Cells
Authors: Zou Xiaomeng , Li Tiantian , Mao Yingxuan , Zhu Mingwei , Chen Xi , Niu Jiamei , Dong Tianxiu , Jiang Jian , Yang Xiuhua
Published: November 2022

Objectives. Preparation of a multifunctional drug‐loaded phase‐change nanoparticle (NP), pirfenidone perfluoropentane liposome NPs (PPL NPs), and combined with low‐intensity focused ultrasound (LIFU) to influence epithelial mesenchymal transition (EMT) for hepatocellular carcinoma (HCC) by inhibiting the activity of activated Hepatic Stellate Cells (a‐HSCs). Methods. PPL NPs were prepared by the thin film dispersion method. The appearance, particle size, zeta potential, encapsulation efficiency, drug loading rate, drug release in vitro, and stability of PPL NPs were tested. The role of a‐HSCs in HCC metastasis was studied by CCK‐8, colony formation assay, apoptosis, cellular uptake assay, wound healing assay, and Transwell assay. Western blot was used to detect the related protein expression levels. In vitro and vivo, the acoustic droplet vaporization (ADV) of PPL NPs was tested at different times and LIFU intensities. Biosafety of the PPL NPs was assessed by measuring nude mouse body weight and hematoxylin and eosin (H&E) staining. Results. The results showed that the PPL NPs had good biosafety, with an average particle size of 346.6 ± 62.21 nm and an average zeta potential of ‐15.23 mV. When the LIFU power is 2.4 W/cm2, it can improve the permeability of cells, further promote the uptake of drugs by cells, and improve the toxicity of drugs. In vitro experiments showed that PPL NPs could inhibit the proliferation of a‐HSCs cells, thereby affecting the metastasis of HCC, and were related to the TGFβ‐Smad2/3‐Snail signaling pathway. Both in vivo and in vitro PPL NPs enhanced ultrasound imaging by LIFU‐triggered ADV. Conclusion. The PPL NPs designed and prepared in this study combined with LIFU irradiation could significantly alter the EMT of HCC by inhibiting LX2. Clinically, PPL NPs will also be considered a promising contrast agent due to their ultrasound imaging capabilities.
Status of Soil Acidity under Different Land Use Types and Soil Depths: The Case of Hojje Watershed of Gomibora District, Hadiya Zone, Southern Ethiopia
Authors: Abure Tesfaye
Published: November 2022

In the humid regions of Ethiopia, soil productivity and fertility are significantly affected by soil acidity, which is connected to infertility and mineral toxicity. The study aimed to assess the status of soil acidity under different land use types and soil depths in Hojje watershed of Gomibora district, Hadiya Zone, Southern Ethiopia, in November 1, 2020. Soil samples (24 nos.) were collected using X-design format from four different land use typeshome garden, cultivated land, grazing land, and Eucalyptus plantation at two soil depths (0–20 cm and 20–40 cm). The soil samples were prepared, their physiochemical characteristics were examined, and statistical analysis was performed. The results indicated that the soil under cultivated land and Eucalyptus plantation were strongly acidic (pH 5.15 and 5.32) with mean values of exchangeable acidity (4.6, 4.59 cmol(+) kg−1) and acid saturation percentage (47.85, 46.96%), respectively. The grazing land was moderately acidic (pH 5.63) and home garden soil was slightly acidic (pH 6.67). The home garden soils had statistically significant (

p
<
0.01

) lower exchangeable acidity (0.64 cmol(+) kg−1) and acid saturation percentage (2.61%). Although, soil pH (H2O and KCl), exchangeable acidity, acid saturation percentage, exchangeable base, CEC, and base saturation are significantly (

p
<
0.01

) affected by both the main effect and interaction effects of the two factors. As a result, it is advised to apply lime to the cultivated land to reduce the acidity of the soil for profitable crop production as the amount of acidity is above the tolerance limit for the area’s locally produced crops.
A SLAM Algorithm Based on Edge-Cloud Collaborative Computing
Authors: Lv Taizhi , Zhang Juan , Chen Yong
Published: November 2022

Simultaneous localization and mapping (SLAM) is a typical computing-intensive task. Based on its own computing power, a mobile robot has difficult meeting the real-time performance and accuracy requirements for the SLAM process at the same time. Benefiting from the rapid growth of the network data transmission rate, cloud computing technology begins to be applied in the robotics. There is the reliability problem caused by solely relying on cloud computing. To compensate for the insufficient airborne capacity, ensure the real-time performance and reliability, and improve the accuracy, a SLAM algorithm based on edge-cloud collaborative computing is proposed. The edge estimates the mobile robot pose and the local map using a square root unscented Kalman filter (SR-UKF). The cloud estimates the mobile robot pose and the global map using a distributed square root unscented particle filter (DSR-UPF). By using sufficient particles in the cloud, DSR-UPF can improve the SLAM accuracy. The cloud returns the particle with the largest posteriori probability to the edge, and the edge performs edge-cloud data fusion based on probability. Both the simulation and the experimental results show that the proposed algorithm can improve the estimation accuracy and reduce the execution time at the same time. By transferring the heavy computation from robots to the cloud, it can enhance the environmental adaptability of mobile robots.
Investigation on the Fracture Properties of Layered Carbonaceous Slate: Experiment and Numerical Simulation
Authors: Zhao Ningning , Feng Jili
Published: November 2022

In order to study the influence of bedding structure on the mechanical properties of rock mass structure, this paper takes the layered carbonaceous slate in the Muzhailing tunnel as the research object, and studies the mechanical properties of layered slate under uniaxial compression and Brazilian splitting. In the numerical simulation, the discrete element software MUSEN (bonded particle model, BPM) is used to simulate the failure behavior of layered rock mass in the process of quasi-static compression. The main research contents of this paper are as follows: (1) the relationship between the microscopic Young’s modulus and the macroscopic Young’s modulus. (2) Influence of tangential shear strength and normal tensile strength on particle model. (3) The influence of different particle distributions on the simulation results. (4) The particle model with different bedding inclinations was simulated numerically. Through the comparative analysis of simulation and experiment, the results show that the mechanical response and failure mode have good consistency, and the splitting evolution process of layered slate with different bedding inclination angles is reproduced.
Prospect Analysis of Paleocene Coalbed Methane: A Case Study of Hangu Formation, Trans-Indus Ranges, Pakistan
Authors: Qadri Hamza Azam , Wahid Ali , Siddiqui Numair Ahmed , Ali Syed Haroon , El Aal Ahmed Abd , Rashid Amirul Qhalis Bin Abu , Temizi Mohd Najib Bin
Published: November 2022

The methane trapped in the coal seams has emerged as an unconventional clean energy resource worldwide in this century. The proximate composition, ultimate content, cleat structure, porosity type, and pore structures are the debatable components for its trapping mechanism. Further, the brittle and ductile properties of minerals influence in the extraction of the methane from the coal seams. In this research, Coalbed methane prospect is demonstrated by analysing the Hangu Formation’s coal seam of Trans-Indus Ranges, Pakistan. This case study is helpful to find the occurrence, trapping ability, and methane extraction capacity in its cleat structures and pores. A number of samples were tested from the different coal mines in terms of these debatable components. The results indicate that the rank of studied coal is bituminous to subbituminous in which the carbon ratio, volatile matter, and sulfur contents are increasing with depth towards the south. The transitional connected face and butt cleats are partially filled with minerals and the intergranular, dissolved, and tissue pore types are also identified in it. It can be helpful for the occurrence, migration, and trapping of methane. Furthermore, the higher surface areas and cumulative pore volumes enhance the capacity of gas adsorption with depth in the study area. Moreover, the increasing brittle minerals in the coal composition towards the south can be helpful for the fracking of coal seams for economical gas extraction. It is suggested that this workflow can be implemented in any region with same coal rank and cleat types.
Continuously Varying Thickness Interference Bandpass Filter for the Visible Spectral Range: Using Ion Beam Sputter Deposition
Authors: Ullah Anayat , Amirzada Muhammad Rizwan , Jahan M. D. Rifat , Khan Yousuf
Published: November 2022

Optical bandpass filters, used to restrict certain wavelengths while allowing other wavelengths to pass, are a common element in many optical devices, such as spectroscopic sensors and hyperspectral imagers. Such filters can be implemented using interference filters, which operate on the principle of constructive and destructive interference. In this work, an interference bandpass filter with continuously varying thicknesses of the constituent films is designed and fabricated for the visible spectral range. Niobium pentoxide and silicon dioxide are used as the filter materials due to the high refractive index contrast between them, resulting in a smaller number of required material films. Ion beam sputter deposition is used as the deposition method due to its ability to produce accurate thickness high optical quality films. The fabricated filter has a transmission band of 130 nm, i.e., 470–600 nm, and can block wavelengths as low as 300 nm and as high as 1080 nm, which is sufficient for use with silicon-based detectors in the visible spectral range. The maximum and minimum transmission inside the transmission band is 96% and 71%, respectively, with an average transmission of 88%. The transmission outside the transmission band is less than 1.6%.
Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts
Authors: Zeng Zifeng , Xu Liwei , Xu Yu , Ruan Yongsheng , Liu Deshen , Li Jiale , Niu Chuanjie , Zheng Shaoyi , Zhou Pengyu , Xiao Zezhou
Published: November 2022

Objective. Adopting hearts from donation after circulatory death (DCD) is a promising approach to enlarge the donor pool. Nevertheless, DCD hearts experience severe warm ischemia/reperfusion (I/R) injury. Recent studies have demonstrated that conditioned medium (CM) derived from bone marrow mesenchymal stem cells (BMSCs) has the potential of reducing organ I/R injury. Therefore, we investigated whether DCD heart preservation with normothermic ex vivo heart perfusion (EVHP) and BMSCs-CM treatment could alleviate myocardial warm I/R injury in the DCD hearts. Methods. We randomly divided donor rats into two groups: (1) DCD-Control group and (2) DCD-CM group. Before DCD heart preservation with the normothermic EVHP system for 105 minutes, rats suffered from a 25-minute warm ischemia injury in the DCD procedure. Vehicle or CM (300 μl) was added to the perfusate at the beginning of the perfusion process. The cardiac function of DCD hearts in the DCD-Control and DCD-CM groups was measured every 30 minutes. Besides, non-DCD hearts were harvested from the beating-heart rats. Results. The antibody array demonstrated that the CM contained 14 bioactive factors involved in apoptosis, inflammation, and oxidative stress. Warm ischemia injury resulted in a significant increase in the level of oxidative stress, inflammation, and apoptosis in the DCD hearts of DCD-Control group. Furthermore, compared with the DCD-Control group, CM treatment increased the developed pressure,

dP
/
d

t

max

and

dP
/
d

t

min

of the left ventricular in the DCD hearts during a 90-minute EVHP. Moreover, the administration of CM attenuated the level of oxidative stress, inflammation, and apoptosis in the DCD hearts of the DCD-CM group. Conclusions. Normothermic EVHP combined with CM treatment can alleviate warm I/R injury in the DCD hearts by decreasing the level of oxidative stress, inflammatory response, and apoptosis, which might alleviate the shortage of donor hearts by adopting DCD hearts.
States and Parameters Estimation for Induction Motors Based on a New Adaptive Moving Horizon Estimation
Authors: Talla Ouambo Steve Alan , Teplaira Boum Alexandre , Moukengue Imano Adolphe
Published: November 2022

This paper investigates the joint states and parameters estimation problem for induction machine. In order to develop new states and parameters estimation methods that greatly improve the estimation bandwidth, this paper proposes an adaptive moving horizon estimation of the crucial states and parameters of the induction machine. The model of the machine under study is the one taking into consideration the magnetic saturation and the iron losses simultaneously. The estimator used is based on a least squares algorithm but includes a dead zone that ensures robustness and a variable forgetting factor that is based on the constant information principle. The simulation results show that the adaptive estimator can efficiently estimate the states and parameters of the induction machine with a fast convergence rate despite the initial parametric errors.
Postoperative Heart Failure with Preserved Ejection Fraction Induced by Flumazenil Administered for Remimazolam Antagonism
Authors: Koh Keito , Omae Takeshi , Sakuraba Sonoko , Kumemura Masateru , Yamazaki Sho , Yunoki Hiroshi
Published: November 2022

Remimazolam is an ultrashort-acting benzodiazepine intravenous anesthetic characterized by rapid awakening after anesthesia. However, the method for administering remimazolam in clinical practice remains unclear. Here, we report a case of postoperative heart failure with preserved ejection fraction (HFpEF) after antagonizing remimazolam with flumazenil. An 82-year-old woman was scheduled to undergo lumbar laminectomy for lumbar spinal canal stenosis. Preoperative echocardiography revealed normal left ventricular systolic function, left atrial enlargement, and impaired left ventricular diastolic function. General anesthesia was induced with 10 mg/kg/h remimazolam and maintained with 0.8 mg/kg/h remimazolam intraoperatively. Before extubation, a total of 1.0 mg of flumazenil was administered. After extubation, the patient developed pulmonary edema due to HFpEF. When remimazolam is administered in elderly patients with cardiac dysfunction, the maintenance dose should be customized according to the patient’s general condition to minimize the dosage of flumazenil.
Analysis and Control of Abnormal Vibration of End Wall on High-Speed Electric Multiple Units
Authors: Wang Dan
Published: November 2022

In view of the abnormal vibration of the body end wall during the high-speed operation of electric multiple units (referred hereafter as EMU), the vibration and noise characteristics of the body end wall area are analyzed through the line test. Combined with the end wall modal simulation results, the generation mechanism of the abnormal vibration of the body end wall is analyzed. The results show that when the train is running at a high speed, the aerodynamic excitation of the windshield cavity outside the body end wall acts on the end wall, arousing the first-order bending natural frequency of the body end wall, resulting in resonance of the body end wall, and then causing abnormal vibration and noise in the body end wall area. In order to solve this problem, installing a deflector (guiding plate) above the windshield in the vehicle body end wall area can effectively suppress the aerodynamic excitation acting on the vehicle body end wall. After optimization, the abnormal vibration and noise in the vehicle body end wall area are significantly reduced. The corresponding peak value at 40 Hz of the vehicle body end wall vibration spectrum is reduced by 85%, and the peak noise is reduced by 12%, The correctness of the mechanism analysis of abnormal vibration in the headwall area is verified, which provides a reference basis for guiding the structural optimization and operation and maintenance of rail vehicles.
A Fault Identification Method of Mechanical Element Action Unit Based on CWT-2DCNN
Authors: Ge Hongyu , Guo Yujiao , Luo Tianyu , Yang Manzhi , Zhang Chuanwei
Published: November 2022

Aiming at the problems of low recognition rate and human intervention in the traditional fault diagnosis of mechanical equipment, a fault identification method based on continuous wavelet transform (CWT) and two-dimensional convolutional neural network (2DCNN) is proposed. By collecting the vibration signals of four kinds of fault states and normal states of the worm rotation unit of the CNC machine tool, the data are preprocessed and identified. Firstly, the vibration signals of each fault state of the element action unit are CWT transformed into the corresponding two-dimensional time-frequency diagram; then, the 2DCNN fault identification model is established, and the time-frequency diagrams of various faults are input to the network as characteristic diagrams for training and testing. Through the adjustment of network parameters, the network performance is gradually optimized; finally, the hybrid domain attention module CBAM is added to further improve the network structure, and the recognition effect is compared with the initial 2DCNN. The results show that the CWT-2DCNN meta-action unit fault recognition model with an attention module can recognize the different states of meta-action units more effectively, and the fault recognition effect is better. By using this method, the different fault types of mechanical element action units can be accurately identified, which has a certain application in the field of mechanical fault identification and diagnosis.
Vacuum Concentration Improves the Quality and Antioxidant Capacity of Pear Paste
Authors: Li Yue , Wang Yongxia , Zhang Xiaoying , Zhao Jiangli , Li Yiming , Cheng Yudou , Guan Junfeng
Published: November 2022

A vacuum concentration method was established to produce pear paste using fresh pear juice in this study. The optimal condition was determined by comparing the quality indexes, contents of total phenol and flavonoid, and antioxidant properties of the pear paste produced by traditional heating concentration and vacuum concentration. Electronic nose and electronic tongue were introduced in this study to provide digital smell and taste indicators. The results showed that the best vacuum concentration temperature was 65°C, which led to the best sensory evaluation score and pear paste quality. The browning degree and soluble quinones were the lowest in all tested temperatures, and the content were 60.12% and 72.88% compared with the heating method, respectively. While the values were 148.29%, 209.44%, 310.86%, 120.37%, 106.24%, and 181.26% of total phenol, total flavonoid, vitamin C, 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) and hydroxyl (·OH) radical scavenging rates, and total reducing power, respectively. The electronic nose could effectively distinguish the vacuum-concentrated pear paste from the traditional heating-concentration pear paste and could provide quality guidance on their flavor differences through characteristic sensors. The electronic tongue tests showed that the vacuum-concentrated pear paste had larger freshness and richness kurtosis. The pear paste made by the optimized vacuum concentration method had higher retention of nutritional and functional components and higher antioxidant capacity, which could be clearly differentiated from the traditional process, thus this method had an applicable potential.
Clinical Course of OCTA en face Imaging Findings in a Patient with HELLP Syndrome
Authors: Konuma Kokoro , Mizobuchi Kei , Watanabe Akira , Nakano Tadashi
Published: November 2022

A 36-year-old primigravid woman with suspected gestational hypertension was referred to our hospital for further examination and treatment of bilateral serous retinal detachment (SRD). At the previous hospital immediately after the onset of visual symptoms (decreased visual acuity), the best-corrected visual acuity (BCVA) had been 0.1 in the right eye (RE) and 0.08 in the left eye (LE). Funduscopy revealed diffuse SRD and white discoloration at the posterior pole but no retinal tear in both eyes (BE). Optical coherence tomography (OCT) also revealed SRD. One day after the onset, we diagnosed bilateral SRD due to preeclampsia with HELLP syndrome because of elevated blood pressure, hemolysis, elevated liver enzymes, and low platelet and performed an emergency cesarean section. One week after the onset, BCVA improved to 0.3 in BE. Funduscopy showed resolution of SRD and the remaining white discoloration at the posterior pole. OCT showed complete resolution of SRD, blurred external limiting membrane, and an invisible ellipsoid zone. OCT angiography (OCTA) segmentation of the deep retinal layer (using en face imaging) revealed multiple white materials, mainly in the macula. Although funduscopy and OCT showed almost normal appearance by 2 months after the onset, BCVA was not completely improved. OCTA using en face imaging revealed shrinkage of multiple white materials but remnant material at the posterior pole. One year after the onset, BCVA was 0.9 in the RE and 0.8 in the LE. OCTA using en face imaging revealed remnant white materials but marked improvement overall.
Surgical Approaches to Optic Disc Pit Maculopathy: A Clinical Case Series
Authors: Pinheiro Rosa Lomelino , Henriques Filipe , Figueira João , Alfaiate Mário , Murta Joaquim Neto
Published: November 2022

The purpose of this study was to compare the clinical outcomes of 13 patients with optic disc pit maculopathy (ODP-M) – progressive visual loss, serous macular detachment, and/or intraretinal fluid – who underwent different surgical approaches. This was a retrospective study including a consecutive sample of 13 patients aged 13–74 years (mean 35.38 ± 19.66 years) diagnosed with ODP-M and submitted to vitreoretinal surgery between 2005 and 2021. All patients underwent pars plana vitrectomy, posterior hyaloid detachment, and gas tamponade. Endolaser photocoagulation was applied to the temporal margin of the optic disc in 8 cases; internal limiting membrane (ILM) peeling was performed in 9 cases; and ILM inverted flap technique in 5 cases. Stuffing of the pit with an ILM flap was performed in 3 cases. Mean best-corrected visual acuity improved from 20/200 (1.04 ± 0.56 LogMAR) to 20/50 (0.43 ± 0.54 LogMAR) within 4–36 months. Central retinal thickness decreased from 587.5 ± 158.01 μm to 253.9 ± 33.55 μm, and 7 out of 10 patients had complete resolution of intraretinal fluid. All patients had complete retinal reattachment; however, a few years after surgery, 4 patients had recurrence of serous retinal detachment. The only adjunctive technique associated with greater visual improvement was endolaser (p = 0.033) and not performing peeling of the ILM was also associated with better visual results (p = 0.013), independently of preoperative visual acuity or age at the time of surgery. None of the adjunctive procedures was a significant predictor of better anatomical outcomes. In conclusion, all of these approaches for the surgical management of ODP-M were safe and effective. In this study, vitrectomy with endolaser was a good option for management of ODP-M.
Relapse of Birdshot Uveitis after Stopping Immunosuppressive Treatment and Starting Immune Checkpoint Inhibitors for Lung Cancer
Authors: Alsaddi Mohammed A.M. , Hondeghem Kathy , Schauwvlieghe Pieter-Paul
Published: November 2022

A 56-year-old Caucasian woman with birdshot uveitis had to stop immunosuppressive treatment with adalimumab due to metastatic squamous lung carcinoma. She was subsequently treated with chemotherapy and pembrolizumab, an immune checkpoint inhibitor (ICI). After stopping adalimumab and starting pembrolizumab, the patient had an inflammatory relapse of birdshot uveitis with macular oedema. Birdshot uveitis is triggered by an unknown antigen presented on the HLA-A29 molecule which activates cytotoxic T-cells. Although immunosuppressive therapy effectively stabilizes birdshot uveitis, it might induce a higher risk of developing cancer. Treatment with ICIs, on the other hand, might exacerbate birdshot uveitis by increasing anti-tumoural immune reaction and inducing off-target autoimmunity.
Surgical Treatment for Adult-Onset Limbal Xanthogranuloma: A Case Report with 4-Year Follow-Up
Authors: Chuephanich Pichaya , Kitsirilarp Warissara , Laoharojvongsa Nutthaporn , Tantayakom Theeratep
Published: November 2022

Xanthogranuloma is a benign histiocytic disorder that generally appears in infants and children and often called juvenile xanthogranuloma (JXG). Typical reddish-yellow cutaneous papules or nodules are the most common presentation of JXG. Extracutaneous JXG affects eyes, brain, lungs, liver, spleen, and other sites. Isolated ocular manifestation without skin lesion is rare, especially in adult patients. Here, we report a case of a 27-year-old man who presented with gradually growing yellowish mass at the corneoscleral area of the left eye for 5 months. The patient had worn soft contact lenses for more than 10 years. With atypical age of onset and the absence of skin lesion, total mass excision with lamellar corneoscleral graft and amniotic membrane transplantation was done, and the diagnosis of adult-onset limbal xanthogranuloma was made by histopathological and immunohistochemical examinations. Postoperatively, the patient had good vision with corrected distant visual acuity of 20/30, and the graft was clear. There was no evidence of recurrence at 4-year follow-up. We found that excision with lamellar corneoscleral graft in limbal xanthogranuloma shows good result with no recurrence. The same result occurred to other previous cases reported, so complete excision with graft could be an effective treatment of choice in patient with limbal xanthogranuloma.
Implantation Cyst of Anterior Chamber: A Case Report
Authors: Peralta Esteban , Etheridge Tyler , Harrie Roger , Lin Amy
Published: November 2022

This clinical case report describes a single case of a progressively enlarging anterior chamber cyst arising in a patient with prior cataract surgery. We detail findings of a large implantation cyst within the anterior chamber, confirmed on ultrasound biomicroscopy. The patient was successfully treated with needle aspiration and injection of 5-fluorouracil without recurrence at 5 months. Anterior chamber cysts are a rare side effect of cataract surgery caused by intrusion of epithelial cells during surgery. Patients may present with a progressively enlarging mass requiring surgical intervention. Aspiration and injection of a cytodestructive chemical agent is one conservative approach in the management of an implantation cyst, with our patient exhibiting favorable visual outcomes.
Qu'est-ce qu'une épopée "nationale" ?
Authors: Boris Maeva
Published: November 2022

Cette étude centrée sur le discours critique vise à interroger les formes de nationalisation dans le commentaire : c’est-à-dire l’ensemble des opérations mises en œuvre par la critique quand elle commente un texte à l’aune d’un espace national. On se propose à cet effet d’étudier un ensemble de commentaires d’épopées dans lesquelles évoluent l’expression « épopée nationale ». On interrogera le degré de lexicalisation de la formule afin de comprendre dans quelle mesure la critique peut présupposer l’existence d’une catégorie générique « épopée nationale », s’y référer et l’intégrer dans des stratégies herméneutiques, sans pour autant la nommer textuellement. On mettra en regard des pratiques discursives contemporaines avec un ensemble d’études de la fin du XIXe siècle déterminé par un contexte épistémique tributaire d’une pensée nationaliste de la littérature.
Mots-Clefs: critique littéraire; genre littéraire; épopée; nation.
On mettra en regard des pratiques discursives contemporaines avec un ensemble d’études de la fin du XIXe siècle déterminés par un contexte épistémique tributaire d’une pensée nationaliste de la littérature.
SENP1 Protects Against Pressure Overload‐Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling
Authors: Yang Dan , Fan Di , Guo Zhen , Liu Fang‐Yuan , Wang Ming‐Yu , An Peng , Yang Zheng , Tang Qi‐Zhu
Published: November 2022

Background

SENP1 (sentrin/small ubiquitin‐like modifier‐specific protease 1) has emerged as a significant modulator involved in the pathogenesis of a variety of human diseases, especially cancer. However, the regulatory roles of SENP1 in cardiovascular biology and diseases remain controversial. Our current study aims to clarify the function and regulation of SENP1 in pressure overload‐induced cardiac remodeling and dysfunction.

Methods and Results

We used a preclinical mouse model of transverse aortic constriction coupled with in vitro studies in neonatal rat cardiomyocytes to study the role of SENP1 in cardiac hypertrophy. Gene delivery system was used to knockdown or overexpress SENP1 in vivo. Here, we observed that SENP1 expression was significantly augmented in murine hearts following transverse aortic constriction as well as neonatal rat cardiomyocytes treated with phenylephrine or angiotensin II. Cardiac‐specific SENP1 knockdown markedly exacerbated transverse aortic constriction‐induced cardiac hypertrophy, systolic dysfunction, fibrotic response, and cellular apoptosis. In contrast, adenovirus‐mediated SENP1 overexpression in murine myocardium significantly attenuated cardiac remodeling and dysfunction following chronic pressure overload. Mechanistically, JAK2 (Janus kinase 2) and STAT3 (signal transducer and activator of transcription 3) acted as new interacting partners of SENP1 in this process. SENP1‐JAK2/STAT3 interaction suppressed STAT3 nuclear translocation and activation, ultimately inhibiting the transcription of prohypertrophic genes and the initiation of hypertrophic response. Furthermore, cardiomyocyte‐specific STAT3 knockout mice were generated to validate the underlying mechanisms, and the results showed that STAT3 ablation blunted the cardiac hypertrophy‐promoting effects of SENP1 deficiency. Additionally, pharmacological inhibition of SENP1 by Momordin Ic amplified cardiac remodeling post‐transverse aortic constriction.

Conclusions

Our study provided evidence that SENP1 protected against pressure overload‐induced cardiac remodeling and dysfunction via inhibiting STAT3 signaling. SENP1 supplementation might constitute a new promising treatment against cardiac hypertrophy. Notably, cardiovascular side effects should be seriously considered while applying systemic SENP1 blockers to suppress tumors.
Community‐Based Evaluation of the Associations Between Well‐Being and Cardiovascular Disease Risk
Authors: McLeish Alison C. , Smith Ted , Riggs Daniel W. , Hart Joy L. , Walker Kandi L. , Keith Rachel J. , Anderson Lauren , Sithu Israel , Pinilla‐Baquero Javier , Srivastava Sanjay , Bhatnagar Aruni
Published: November 2022

Background

Although the effects of psychological health and optimism have been extensively investigated, data from community‐based cohorts assessing the association between psychological health and cardiovascular disease risk factors are sparse, and the concurrent relationship between subjective well‐being and cardiovascular health has not been studied.

Methods and Results

The current cross‐sectional study examined the association between well‐being and cardiovascular risk factors among 719 individuals living in a middle‐ to low‐income neighborhood. After adjusting for age, sex, race, body mass index, education, smoking status, and exercise status, we found that higher levels of well‐being were significantly associated with lower odds of dyslipidemia (odds ratio [OR], 0.7 [95% CI, 0.55–0.85]) and hypertension (OR, 0.8 [95% CI, 0.63–0.92]). Greater well‐being was also significantly associated with lower triglyceride levels (mean difference [M
diff
], 7.6 [−14.31 to −0.78]), very low‐density lipoprotein (M
diff
, 0.9 [−1.71 to −0.16]), total cholesterol to high‐density lipoprotein ratio (M
diff
, 3.9 [−6.07 to −1.73]), higher high‐density lipoprotein levels (M
diff
, 1.6 [0.46–2.75]), and lower Framingham Risk Scores (M
diff
, −7.1% [−10.84% to −3.16%]). Well‐being also moderated the association between age and arterial stiffness. The strongest association between arterial stiffness and age was found for those with the lowest well‐being scores; there was no association between age and arterial stiffness at high levels of well‐being.

Conclusions

In a community‐based cohort, individuals reporting higher levels of well‐being have lower odds of hypertension and dyslipidemia as well as lower rates of age‐dependent increase in vascular stiffness.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03670524.