bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISPR/Cas9-mediated Genome Editing: In vivo Review
Authors: Lotfalizadeh Narges , Sadr Soheil , Ahmadi Simab Pouria , Hajjafari Ashkan , Borji Hassan , Bayat Zeynab
Published: July 2023

The CRISPR/Cas9 system has been a game-changer in genetics and biotechnology. This study aimed to investigate the existing in vivo uses and their potential to increase our understanding of gene function and biological processes in animal models. With its remarkable precision and accuracy, researchers can now easily edit specific genes within cells and organisms. This technology has opened up new avenues for studying genetic diseases and developing therapies to treat them. One of the most significant advantages of the CRISPR/Cas9 system is its ability to create precise cellular and animal models of human diseases. This allows researchers to investigate the role of genetics in disease development and to develop more effective therapies. For example, the system can correct genetic mutations that cause cystic fibrosis or sickle cell anemia. The therapeutic potential of CRISPR/Cas9 is enormous, especially in gene therapy. By correcting specific genetic mutations, the system can potentially treat human diseases that are currently untreatable with conventional therapies. However, some challenges still need to be addressed before this technology can be used in clinical settings. Despite these challenges, the potential of CRISPR/Cas9 to revolutionize the field of genetics and biotechnology cannot be overstated. Ultimately, this technology has the potential to transform medicine by providing new therapies for a wide range of genetic diseases.
Relapse of Pulmonary Tuberculosis in Patients with Resistance to Isoniazid
Authors: Burmistrova I. A. , Lovacheva O. V. , Samoylova A. G. , Vasilyeva I. A.
Published: July 2023

The objective: to study the incidence of relapses over a two-year period after successful completion of chemotherapy in patients with isoniazid-resistant tuberculosis (Hr TB), to determine the risk factors for relapses in this cohort.

Subjects and Methods. The medical records of 1860 Hr-TB patients who started treatment in 2015 in TB hospitals in 18 regions of the Russian Federation were retrospectively studied. Of these, 1271 (68.3 ± 1.08%) patients successfully completed a full course of chemotherapy, which were divided into two groups depending on the presence/absence of relapse in the next two years.

Results. Tuberculosis relapse was observed in 131/1271 (10.31%; CI 8,75–12,10%) (R+ Group) patients, the remaining 1140 patients

(R– Group) developed no relapse. For R+ and R– Groups, the first episode of the disease (FED) was analyzed, for R+ Group, the episode of the disease recurrence detection (DRD) was also analyzed. The risk factors for relapse development include the following parameters that were available in patients during first episode of the disease: unemployment at working age (OR=1,98; 95% CI [1,36–2,88]), diabetes mellitus or chronic alcohol addiction (OR=3,93; 95% CI [2,13–7,26%] and OR=2,25; 95% CI [1,02–5,01]), lung tissue decay OR=2,01; 95% CI [1,31–3,07], and drug resistance of Mycobacterium tuberculosis (H+Ag+Fq) (OR=7,26; 95% CI [3,90–10,62]).

With the disease recurrence detection, out of 131 patients of R+ Group, the positive results of the sputum test was recorded only in 117 (89,3%) patients, 41/131 (31,3%) patients developed a different clinical form of tuberculosis versus the first episode of the disease, and in 12/41 ( 29,3%) or 12/131 (9,2%) patients, the disease was more severe. 44/117 (37,6%) patients had been already resistant to rifampicin. It means they had developed MDR TB before the relapse was detected.
Delamanid in the Treatment of MDR/pre-XDR TB in Arkhangelsk Region in 2019–2021
Authors: Khimova E. S. , Perkhin D. V. , Sveshnikova O. M. , Makhmaeva S. V. , Verkhovaya V. N. , Eliseev P. I. , Nikishova E. I. , Maryandyshev A. O.
Published: July 2023

The objective: to evaluate the efficacy and safety of delamanid in a short-course treatment regimen for patients with MDR/pre-XDR pulmonary tuberculosis in Arkhangelsk Region from 2019 to 2021.

Subjects and Methods. 32 patients (4 with MDR TB and 28 with pre-XDR TB) started treatment with delamanid within the combination chemotherapy with new drugs, treatment lasted for 12 months. All patients with pre-XDR TB received delamanid, bedaquiline, linezolid, and clofazimine, then the chemotherapy regimen was compiled depending on the clinical situation.

Results. Effective treatment was registered in 21/32 patients (65,6%). 4/32 (12,5%) patients interrupted the treatment. Treatment failure was registered in 2/32 (6,25%). During the study, 5 (15,6%) patients died, in none of them tuberculosis was the cause of death. 106 adverse events (AEs) were reported, they included electrolyte imbalance (18,9%), hepatotoxic (16,0%), nephrotoxic (10,4%) and cardiotoxic (10,4%) reactions.
Industrial Design Studios of Warsaw: Pushing Forward For Socially and Ecologically Responsible Design
Authors: BENGİSU Murat , ERDOĞANLAR BENGİSU Füsun
Published: July 2023

The aim of this research was to understand the approaches of Polish design studios to project management as well as socially and ecologically responsible design. These issues were investigated through a perspective of Polish design history and today’s socioeconomic realities. A qualitative approach was used in this study with interviews as the main research method. Recorded interviews were deciphered and coded according to common themes within the answers. Five prominent industrial design studios based in Warsaw were interviewed and their design projects were analyzed in detail. Common threads among these projects appear to be a natural evolution of the democratic design approach that started in the ‘60s in Poland and other Baltic countries. The design philosophy, project management, and resulting products suggest that Polish design studios struggle to keep active, competitive, and innovative through ecologically and socially responsible design in spite of the conventional market demand emphasizing styling and form in industrial products. Challenges such as financial limitations, low prices paid for design projects, and having to deal with a broad range of design activities are overcome by using different strategies such as research about local culture and resources, user studies, experimentation with new concepts and materials, professional networking, cooperation with academia, and using national or international funds.
Urban poverty in Burundi : salient reasons and church response
Authors: Bahizi Thierry
Published: July 2023

This handbook is a deep dive on the causes of urban poverty in Burundi (Africa) guided by the results of an extensive research carried out by the author, Doctor in Theology and expert in Urban Ministry and Missiology. The analysis Thierry Bahizi offers here arises from a holistic viewpoint, including not only the variable of physical, also called material, poverty, but also its spiritual side. Along its pages, the reader is going to find a complete relation of the multiple faces of poverty in the urban nuclei of Burundi, how the local Churches and Parishes can and, in fact, do tackle the situation, and the essential conclusion on the importance of the spiritual work for pauperized collectives.
The importance of interdisciplinary work between physiotherapists and physical education professionals in bodybuilding gyms: an integrative literature review
Authors: Soares Natalia de Jesus Santos , Damaceno Jamile
Published: July 2023

Nobody can deny the benefits that well-structured exercise practices can provide to people. However, one of the disadvantages of these practices is the risk of injuries. This work aimed to describe the importance of physiotherapists’ performance in weight training gyms working together with physical education professionals. An integrative literature review has been performed using the databases: SciELO, LILACS, PubMed, and Google Scholar, in addition to articles and books. The chosen inclusion criteria were articles published in Portuguese, English, or Spanish between 2009 and 2023, while no range was established for books. Data indicate that failure to diagnose changes during the client’s evaluation can lead to incorrect exercise prescriptions and future problems. The literature indicates that the most injured body parts are the shoulder, knee, and lumbar spine. Low back pain and tendonitis were the pathologies with the highest incidence. The lack of physiotherapists in gyms could be associated with the costs. It has been well documented that the physiotherapist has the necessary knowledge to prevent musculoskeletal injuries or postural changes and prevent the recurrence of existing problems from worsening. Therefore, the multidisciplinary work between the physiotherapist and the physical educator is necessary to promote the well-being of individuals who attend the gym.
The performance of pedagogues in socio-educational units: possibilities and challenges
Authors: Silva Sabrina Maria , Nascimento Bruna Maria
Published: July 2023

The pedagogue plays an essential role in developing pedagogical practices in juvenile detention units. However, building significant work in the space of deprivation of freedom is challenging. This article aims to deal with the pedagogue’s role in social-educational units, highlighting the challenges and possibilities of the practices. To do so, exploratory research and bibliographic studies on the topic were carried out. The results point to issues related to initial training, the need to develop public policies and reflective pedagogical practices, and the construction of the Individual Plan of Attendance (PIA). We conclude that education is the individual’s right, besides contributing to freedom and social transformation. Therefore, the pedagogue’s performance must be guided by practices that do not reinforce marginalization and social exclusion.
História da educação no curso de pedagogia: avanços, desafios e perspectivas
Authors: Silva Joao Carlos da
Published: July 2023

O presente artigo aborda a trajetória da disciplina de História da Educação no curso de graduação de Pedagogia da Universidade Estadual do Oeste do Paraná (UNIOESTE), campus Cascavel, tendo como recorte temporal, a fundação do referido curso e sua última reformulação. Tem como objetivo examinar a sua importância na formação de professores. A metodologia parte do estudo bibliográfico de aportes teóricos referenciados no campo da História da Educação, como: Saviani (2000), Lopes e Galvão (2001), Stephanou e Bastos (2011). Em face das políticas de aligeiramento na formação do pedagogo, percebe-se a intensificação de um discurso em favor da constituição do professor com base pragmática, com fortes restrições às disciplinas de cunho crítico, histórico e filosófico no preparo desse futuro profissional. Isso ocorre sob a justificativa da necessidade de uma formação mais técnica, isto é, que priorize certas competências que atendam às demandas emergenciais do mercado de trabalho.
KAPITALISASI LEMBAGA PENDIDIKAN ISLAM
Authors: M. Yunus  , Dian Dwi Alifatul Faizah
Published: July 2023

The problems of Islamic education that are developing in schools today are numerous, one of which is capitalism Islamic education, education that the rights of each individual person are limited by financial ability. That is the high cost of private education, which in fact is an Islamic educational institution that usually has the word Islam behind the name of the school, such as Islamic elementary school, Islamic junior high school and the like. make education has come out of its true purpose. The paradigm of Islamic education does not distinguish between social groups in society, because learning is the right of every individual, everyone has the right to get a school education. It is time for us to implement the "social justice" paradigm, using the "human empowerment approach". approach to placing humans as humans. Humans are not adapted to goods. Humans are independent-autonomous beings, have potential that can be developed and realized. So it's fair that education will be implemented if we are all serious about transforming education with the concept of "humanizing humans".
Peran Sosiologi Pendidikan dalam Menguatkan Karakter Siswa melalui Manajemen Pendidikan
Authors: Rodja Zakiyah , Nuraini Salsabila  , Nindia Monita Br Ginting  , Vinsensia Carolin Purba
Published: July 2023

Pendidikan tidak hanya tentang penguasaan pengetahuan akademik, melainkan juga pembentukan kepribadian yang kuat pada siswa. Oleh karena itu, manajemen pendidikan yang berbasis sosiologi pendidikan sangatlah penting untuk memperkuat karakter siswa secara menyeluruh. Peneliti menggunakan metode studi pustaka untuk mempelajari peran sosiologi pendidikan dalam membentuk karakter siswa melalui manajemen pendidikan. Tujuan penelitian ini adalah untuk mengumpulkan dan menampilkan bahan bacaan yang relevan mengenai fungsi sosiologi pendidikan dalam meningkatkan karakter siswa melalui manajemen pendidikan. Dari hasil penelitian, dapat disimpulkan bahwa manajemen pendidikan berbasis sosiologi pendidikan dapat membantu membentuk karakter siswa dengan bantuan pranata sosial dalam menanamkan nilai-nilai tertentu pada peserta didik. Selain itu, integrasi nilai-nilai karakter dalam kurikulum menjadi sangat penting. Setiap mata pelajaran harus memasukkan pembelajaran tentang integritas, tanggung jawab, kerja sama, dan toleransi agar karakter siswa dapat diperkuat secara menyeluruh.
IMPLEMENTASI MODEL PEMBELAJARAN BERBASIS CONTEXTUAL TEACHING AND LEARNING (CTL) PADA MATA PELAJARAN KEWIRAUSAHAAN DI KELAS XII SMK DARUNNAJAH 2 BOGOR
Authors: Ahmad Cholil  , Abdul Saipon  , Irman Sumantri  , Farid Ahmad Farid
Published: July 2023

This research was explored in depth from the contextuality aspect of the study, and the research methodology design aspect. With a mixed method design (a combination of qualitative and quantitative methods), the results of data analysis show that the implementation of the CTL concept at SMK Darunnajah II Bogor is carried out by following its main components, namely constructivism, inquiry (finding and solving problems), questioning (asking questions). ), learning community (learning community), modeling (modeling), reflection (reflection), and authentic assessment (authentic assessment). The CTL approach implemented in the entrepreneurship subject at Darunnajah Cipining Vocational School, in addition to teaching students to be more critical in the learning process, to be more active, sensitive, and creative in analyzing issues relevant to entrepreneurship subject matter, teachers also teach students to in the context of the values ​​taught by Islam and internalized at the Darunnajah Islamic Boarding School, namely the principle of mutual benefit, not tyrannizing, and not dominating or harming each other, and intended to build a better life and economy for the ummah. The outline of the results of the analysis of student perceptions regarding the implementation of CTL in the entrepreneurship subject at SMK Darunnajah II Bogor shows that as much as 91.38% of the total respondents stated that the CTL concept was very effective in the context of the relevance of material to everyday life experiences and reflections on learning from problem analysis .

Keywords: contextual teaching and learning, reflection, inquiry, learning model.
PENGARUH IKLAN DAN HARGA TERHADAP MINAT BELI KONSUMEN PADA SEHAT BAKERY SIBULUAN INDAH
Authors: ILHAMSYAH POHAN  , Rosmita Ambarita  , Nur’ainun Hasibuan
Published: July 2023

Tujuan penelitian ini adalah Untuk mengetahui Apakah iklan dan harga berpengaruh secara bersama-sama terhadap minat beli konsumen pada Sehat Bakery Sibuluan Indah. Rumusan masalah penelitian ini adalah Apakah Iklan dan Harga berpengaruh secara bersama-sama Terhadap Minat Beli Konsumen Pada Sehat Bakery Sibuluan Indah ? Hipotesis dalam penelitian ini adalah Terdapat pengaruh Iklan dan harga terhadap minat beli konsumen pada Sehat Bakery Sibuluan Indah. Jenis penelitian penelitian deskriptif kuantitatif (descriptive quantitative research) yang digunakan. Populasi sebesar 430 orang. Sampel berjumlah 100 orang. Sumber data berasal dari data primer dan sekunder. Data dianalisis menggunakan analisa deskriptif dan analisis kuantitatif.

Hasil penelitian diketahui variabel iklan dan harga mampu mempengaruhi variabel minat beli konsumen sebesar 45,2%. Iklan dan harga secara serempak berpengaruh positif dan signifikan terhadap minat beli konsumen di Sehat Bakery Sibuluan Indah, dimana diperoleh bahwa nilai Fhitung (39,965) lebih besar dibandingkan dengan Ftabel (3,09) dan Sig.á (0,000a) lebih kecil dari alpha 5% (0,005). Secara parsial iklan berpengaruh positif dan signifikan terhadap minat beli konsumen di Sehat Bakery Sibuluan Indah. Dibuktikan dengan nilai thitung yang diperoleh 3,074 lebih besar dari ttabel 1,984 atau signifikansi (sig-t) 0,003 lebih kecil dari α (0,05). Secara parsial harga berpengaruh positif dan signifikan terhadap minat beli konsumen di Sehat Bakery Sibuluan Indah. Dibuktikan dengan nilai thitung yang diperoleh 6,847 lebih besar dari nilai ttabel sebesar 1,984 atau signifikansi (Sig-t) 0,000 lebih kecil dari α (0,05) Berdasarkan model regresi liner berganda yang diperoleh persamaan regresi adalah Y = 5,299 + 0,259 + 0,560 menunjukkan kinerja kearah yang positif.
Pengaruh Servant Leadership Style dan Komunikasi Interpersonal Terhadap Motivasi Kerja Pegawai Melalui Komitmen Organisasi
Authors: Khurniawan Danang , Prasetyo Indra , Utari Woro
Published: July 2023

The aims of this study are to describe work motivation, organizational commitment, Servant Leadership Style and interpersonal communication of employees at the Bojonegoro Regency Pusda Office. To analyze the effect of Servant Leadership Style and interpersonal communication on employee motivation through organizational commitment. This type of research is explanatory research and the approach in this research is quantitative. The population is all employees of the Bojonegoro District Pusda Office, totaling 52 people. The sampling technique uses total sampling or saturated sampling, so the sample used is 52 people. In this study, data analysis used Structural Equation Modeling (SEM) and PLS (Partial Least Square) software. The results showed Servant Leadership Style, Interpersonal Communication, Organizational Commitment and Work Motivation in the high category. There is no significant effect between Servant Leadership Style on organizational commitment. There is a significant influence between interpersonal communication on organizational commitment. There is no significant effect between Servant Leadership Style on work motivation. There is a significant influence between interpersonal communication on work motivation. There is a significant influence between organizational commitment on work motivation. There is no significant effect between Servant Leadership Style on work motivation through organizational commitment. There is a significant influence between interpersonal communication on work motivation through organizational commitment.
PENGARUH ETIKA KERJA DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI PADA KANTOR KECAMATAN SIBOLGA SAMBAS
Authors: Tuti Alawiyah Tanjung  , Kaharuddin  , Rosmita Ambarita
Published: July 2023

The formulation of the problem in this study is whether work ethics and work motivation have a positive and significant effect on employee performance at the Sibolga Sambas District Office.

This study aims to determine the effect of work ethics and work motivation on employee performance at the Sibolga Sambas District Office.

The sample in this study were all employees of Sibolga Sambas District, totaling 87 (eighty seven) people. The data analysis technique in this study is Multiple Linear Regression.

The results of this study indicate: work ethics partially has a positive and significant effect on employee performance; Work motivation partially has a positive and significant effect on employee performance; Work ethics and work motivation partially have a positive and significant effect on employee performance.
ANALISIS RATIO LIKUIDITAS DAN SOLVABILITAS PADA TOKO SURYA BARU SIBOLGA
Authors: Sri Ulina Tarigan  , Zafril Abdi Nasution  , Mhd. Shafwan Koto
Published: July 2023

The purpose of this research is to find out what are the current liquidity ratios, solvency ratios and general ratios in an effort to improve the company's financial performance. The population of this study is the 2019-2021 Financial Statements of Toko Surya Baru Sibolga. The data collection method used is to use library research methods. The type of data used in this research is secondary data in the form of annual reports. The data analysis method used is descriptive analysis which aims to analyze data by describing or describing data using measurements of liquidity ratios (current ratio, quick ratio and cash ratio) and solvency ratios (debt to asset ratio, debt to equity ratio and long term debt to equity ratio). The results of the analysis are as follows (1) the liquidity ratio, according to the calculation of the average for 2019-2021, the current ratio is 188.27%, the quick ratio is 47.48%, and the cash ratio is 28.02%, indicating unfavorable conditions , because the resulting ratio is too low, especially the quick ratio and cash ratio, the company is advised to optimize its current assets, by expanding the business and suppressing the collection of uncollected company receivables. (2) the solvency ratio, according to the calculation of the average 2019-2021 debt to asset ratio, is 22.17%, the debt to equity ratio is 28.67%, and the long term debt to equity ratio is 11%, indicating the condition a good company, the company is expected to maintain financial performance so that the solvency ratio remains at the internal average because the smaller the ratio, the better the company's financial performance
FAKTOR-FAKTOR YANG MEMENGARUHI AUDITOR SWITCHING SECARA VOLUNTARY
Authors: Nur Aini  , Muhammad Aufa
Published: July 2023

The aim of this study is to examine factors that affect auditor switching voluntarily. Variables that consider to have effect on auditor switching are audit tenure, change of management, size of public accountant firms, and financial distress. This study used 78 observation of annual report from palm oil companies that listed in Indonesia Stock Exchange period 2018-2021. The examination was used logistic regression to analyze and SPSS 25 as programmer. Result of the study stated that simultaneous audit tenure, change of management, size of public accountant firms, and financial distress significantly affect auditor switching voluntarily. Partially, change of management is the only variable that significantly affect auditor switching voluntarily. This study can be used by companies to consider voluntary rotation of auditor and auditor to improve performance in providing audit services. The limitation of this study are the use of the independent variables and the sample that used are not common sample so there was no concrete comparison.
ANALISIS PROFITABILITAS PADA PT. DUTA PERTIWI NUSANTARA
Authors: Rifal Dwi Putra  , Tegar Zaki Hanafi  , Taufiq Akbar Dewi Fidrdaus  , Ratih Kusumastuti
Published: July 2023

This research was conducted to collect information about financial statements from 2021-2022, namely the balance sheet and income statement at PT Duta Pertiwi Nusantara. This study uses a theoretical basis from financial management theory regarding profitability ratio analysis of financial statements, the analytical tools used in this study are Gross Profit Margin, Net Profit Margin, Return on Investment and return on Equity. Based on the results of the analysis, it shows that the Gross Profit Margin of PT Duta Pertiwi Nusantara has decreased from 2021-2022, seen from the Net Profit and Return on Equity Margin during 2021-2022 the results show the same percentage, which has decreased in 2022. Then the Return On Investment achieved during 2021 to 2022 experienced a slight increase in 2022. The results of this study indicate that the profitability ratios in the financial statements of PT Duta Pertiwi Nusantara have not been stable and Based on the problem formulation of this study, namely "How much is the analysis of profitability ratios in the financial statements of PT Duta Pertiwi Nusantara. "How much is the analysis of profitability ratios in the financial statements of PT. Duta Pertiwi Nusantara", it is concluded that the Profitability Ratio has a very large influence on the financial statements of PT. Duta Pertiwi Nusantara because we can understand the company's financial condition.
MENINGKATAN MINAT MEMBACA MELALUI GERAKAN LITERASI SEKOLAH DI SDN BERU KECAMATAN SARIREJO
Authors: Nur Ani Heti , Salukh Agustinus , Mahmudah Annita , Rodhiyah Ma'rufatur , Dilasari Aranta Prista , Kartikasari Evi Dwi , Wijaya Andik
Published: July 2023

The word literacy is now very familiar to the public. We define someone who is literate as someone who is literate or can read.  Reading has a very strong cultural influence on the literacy development of students.  Unfortunately, student achievement at SDN Beru is still low.  Therefore, in community service in Beru village, we held a literacy movement program to increase interest in reading. The implementation method applied is to provide assistance by interacting directly with students through teaching and learning activities in the classroom. The goal is that students at SDN Beru can read. The result of this service is that students gain new knowledge from the literacy movement.
ANALISIS PENGARUH BUDAYA KESELAMATAN KERJA TERHADAP KEPATUHAN PENGGUNAAN ALAT PELINDUNG DIRI (APD) PEKERJA DI BAGIAN LABORATORIUM AIR PT UNILAB PERDANA JAKARTA SELATAN
Authors: Silmi Ai , Kurniawan Deni
Published: July 2023

This study aims to determine and analyze the safety culture (knowledge, attitude towards regulations, personality, availability of equipment, training, and motivation) that affect the compliance with the use of Personal Protective Equipment (PPE) of workers at the Water Laboratory of PT Unilab Perdana, South Jakarta. The research method used is quantitative with an explanatory format. The population of this study were 17 workers in the water laboratory of PT Unilab Perdana, South Jakarta. The sampling technique is a saturated sample, that is, all members of the population are used as samples. The research sample was 17 workers in the water laboratory of PT Unilab Perdana, South Jakarta. The research data collection technique used a questionnaire on compliance with the use of PPE on workers as the dependent variable and knowledge, attitude towards regulations, personality, availability of equipment, training, motivation as independent variables. Data analysis used simple correlation regression, t test, and coefficient of determination. The results showed that safety culture had a positive and significant effect on compliance with the use of PPE. The results of the t-test for tcount are greater than ttable, namely 3.493 > 2.109 at = 0.05 and 2.898 at = 0.01. This means that the correlation coefficient of safety culture on compliance with the use of PPE is significant. The coefficient of determination of the influence of safety culture on compliance with the use of PPE is obtained from the R square value of 0.449. So 44.9% of the variance in safety culture can be explained by the variable of compliance with the use of PPE. From the results of hypothesis testing, the findings show that safety culture has a positive and significant effect on compliance with the use of PPE. This means, the higher the safety culture, the higher the compliance with the use of PPE. Based on these findings, it can be concluded, if you want to improve compliance with the use of PPE, then the safety culture needs to be improved as well.
Best Practices in Curriculum Implementation Through the Experiential Learning Cycle
Authors: Ogunseemi Olatunbosun Emmanuel , Idowu Ezekiel Kayode
Published: July 2023

The aim of teaching is to learn, and more importantly to relate what is learnt with real world experience. Therefore, this paper explores best practices for curriculum implementation using the experiential learning cycle for effective classroom interactions. It discusses: the curriculum; the curriculum implementation; experiential learning cycle to show the impact of Engagement, Exploration, Integration; evaluation to enhance classroom interactions; how can the experiential learning cycle support curriculum implementation; benefits of curriculum implementation.
A Scoping Review of the Literatures on the Relationship Between Childhood Stunting and Dental Caries
Authors: Rafisa Anggun , Balafif Felisha Febriane , Najmi Nuroh , Kuswandani Faisal
Published: July 2023

Stunting, as an indicator of chronic malnutrition, can affect a variety of body systems, including the development of various dental diseases and disorders. The objective of this study is to map the scope of existing research on the relationship between stunting and dental caries. This scoping review utilized two database search engines (Scopus and PubMed) using the keywords "stunting" and "caries". The article selection process was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol. Following an assessment of titles, abstracts, and full-texts, 23 articles were identified as relevant to the study objective and were included in this review. The majority of the studies (69.6%) used a cross-sectional design and examined more than 500 samples (47.8%). Most studies were conducted on the Asian and African continents, examined caries in primary teeth, and used WHO growth standards to define stunting. The study findings on the correlation between stunting and caries in primary and permanent teeth revealed varying results depending on study design, sample size, and settings. All of the studies included in this review were performed in lower-middle income countries (LMICs). The publication regarding the correlation between childhood stunting and caries in permanent teeth is still lacking, mainly because the utilization of cross-sectional research design. Other risk factors, as well as the use of different research methods, could explain the variations in the findings of the studies included in this review.
"REVIEW: BREAKING THROUGH BARRIERS TO EDUCATION AND SOCIAL INCLUSION FOR MUSLIM WOMEN"
Authors: MANZAR MD MANZAR REZA
Published: July 2023

Md Manzar Reza, Research Scholar in English, 

                                                                                                      RKDF UNIVERSITY, RANCHI.

                                                                                                      Email ID: manzarreza0301@gmail.com

                                                                                                      Mobile Number:- 7797806084

ABSTRACT

The article "Breaking Through Barriers to Education and Social Inclusion for Muslim Women" is the subject of this review, which assesses the challenges experienced by Muslim women in obtaining an education and social inclusion. The study points out a number of institutional, cultural, and religious impediments to education and social inclusion, including patriarchal societal norms, shoddy school systems, and restricted access to high-quality education. It emphasises the need of creating policies and initiatives especially created to meet the requirements of Muslim women, thereby allowing their engagement in education and society. The document goes on to say that these policies should be aimed at removing structural obstacles to social participation and education, as well as allowing Muslim women to develop their own agency and voice. The study comes to the conclusion that this article offers an insightful look at the difficulties Muslim women have in gaining access to education and social participation, as well as possible ways to remove these obstacles.

This evaluation comes to the conclusion that the article offers a thorough summary of the difficulties Muslim women have while trying to attain education and social participation. It underlines the necessity for specialised policies and initiatives that concentrate on removing structural obstacles and enabling women to find their own agency and voice. As a result, it makes a significant contribution to the body of knowledge about Muslim women's involvement in education and society.

Keywords: education, Muslim women, refuges, cultural norms, barrier of education.
Smoking cessation service in the pharmacy setting: Attitudes of pharmacy students, pharmacists and the general public
Authors: Milošević-Georgiev Andrijana , Obradović Dragiša , Krajnović Dušanka
Published: July 2023

Smoking is a global public health problem, and control measures should be implemented in the community so as to reduce the number of smoking-related diseases and healthcare costs. Community pharmacies are ideal places for providing tobacco cessation counselling as a type of public health service, because they are the most accessible health facilities with direct contact with patients. We aimed to examine attitudes towards the implementation of such services, conducting surveys on a sample of pharmacy students (N=300), community pharmacists (N=383) and the general public (N=987) in the Republic of Serbia. The introduction of smoking cessation services at pharmacies was supported by pharmacy students (59.7%), pharmacists (49.2%), and the general public (36.7%). No difference was found between pharmacistsàttitudes in terms of their gender, age, level of education and years of experience. We found evidence that pharmacists as public health practitioners were recognized mostly by students (94.3%). The majority of them (86.3%) recognized the need for additional education in order to implement new services, and every third pharmacist recognized a gap in their education. The data indicate the need for directed research in order to explore the educational needs and competences for practicing pharmacists and enable them to perform services such as smoking cessation in the future.
Why EWSs for financial crises failed during the Covid-19 pandemic: The example of Serbia
Authors: Nikolić Ivan , Kovačević Miladin , Stančić Katarina
Published: July 2023

Early warning systems (EWSs) are designed to anticipate future crises, giving policymakers optimism that they would be able to make proactive management decisions. The demonstration of EWSs effectiveness in the economy was clear throughout the Asian financial crisis at the end of the 1990s, the financial crisis of 2007-2008, the Great Recession, and the European sovereign debt crisis of 2008-2012. However, EWSs failed during the COVID-19 pandemic. Using Eichengreen et al. [13], Kaminsky et al. [23], and Sachs et al. [33] methodology, the paper explains this phenomenon by analyzing the determinants of currency crises episodes in the Republic of Serbia from January 2001 to December 2021. The complexity of the current crisis required a change of approach. As reflected by the Statistical Office of the Republic of Serbia, one of the solutions is to develop a Decision-Making Support System (DMSS). EWSs presented here could serve as one of the many inputs in the assessment and identification of financial crises. However, these models are not accurate enough to be used as the sole method to anticipate crises. Like other crisis models, they bring benefits but obviously have their drawbacks. That is why it would be good to put them under the auspices of a more complex DMSS. Again, for now DMSS should be seen just as a better alternative to earlier practice. This is neither a final nor an almighty option, but it must be further worked on in the future.
Influence of Euribor on interest rates on new loans granted to corporates and households: The case of Serbia
Authors: Simović Danka , Šutaković Teodora
Published: July 2023

The paper deals with the impact of the Euribor and risk premium on interest rates on foreign currency loans and FX-indexed loans that are approved to the corporate sector and the household sector in Serbia. Total new loans granted to corporates, total new loans granted to households, new investment loans granted to corporates and new housing loans granted to households are observed. The observed period is from September 2010 to August 2020. The main goal is to determine whether there is a long-run relation between Euribor and risk premium and the given interest rates, and what is the strength of the given relation. Empirical estimates show that there is a statistically significant impact of Euribor, as well as country risk premium, on lending rates on new households as well as corporate investment FX and FX-indexed loans, with high passthrough coefficients. For the total new corporate FX and FX-indexed loans we also included nonperforming loans as explaining variable which is shown to be statistically significant and whose fall also influenced the fall of lending rates on these loans.
The impact of interactive digital technology exposure on generation Z students learning performance in computer graphics and simulations: A comparative study of Greece and Serbia
Authors: Aleksić Veljko , Politis Dionysios
Published: July 2023

As the functionality of modern digital societies is largely based on interactive digital technology, educational technology has inevitably gone through a process of digitalization. Studying information technology, computer science, or computer engineering in the post-digital era makes it very hard for students to disjoin personal technology needs, learning necessities, and future career demands, putting them at great risk for developing psychological disorders. The aim of this international comparative study is to examine the effects of interactive digital technology exposure on learning performance in computer graphics and simulations. To conduct a comparison of the 397 generation Z students from Greece and Serbia, a study was conducted evenly representing various geographic, economic, and socio-cultural environments. The research was realized between October 2021 and May 2022. The type of preferred gaming device was the most important digital technology exposure predictor of learning performance factors gain both in Greece and Serbia. Unexpectedly, digital gaming exposure and Internet gaming disorder were not significant predictors of academic success. The resulting model dually provides teachers with the opportunity to adapt their activities more efficiently and students with a self-diagnostic tool helping them to improve learning performance in the field of computer graphics and simulations more effectively.
Čega se deca igraju, čime i gde - sagledavanje igre iz dečje perspektive
Authors: Kovačević Zorica , Gluvak Jadranka
Published: July 2023

Teorijske i empirijske studije potvrđuju značaj igre u ranom uzrastu kao sredstva pomoću kojeg deca grade jaku osnovu za kognitivne, socijalne i emocionalno koncepte. Igra se ne može uvek uredno svrstati u određenu kategoriju, ali praćenje formi u kojima se ona pojavljuje pomaže odraslima da se senzibiliziraju za promenljive situacije koje deca stvaraju i pruža alat za procenu mogućnosti koje sredina nudi za različite vrste igara. U ovom radu predstavljeno je istraživanje koje je imalo cilj sagledavanje dečje perspektive o igri - zašto se deca igraju, u kojoj meri su zastupljene pojedine dečje igre, koje prostore deca biraju za svoju igru i koje materijale koriste u igri. Za realizaciju ovoga istraživanja korišćena je deskriptivna metoda sa tehnikom nacrtaj i reci. Istraživanjem je obuhvaćeno 47 dece uzrasta od četiri do sedam godina. Realizovano istraživanje je pokazalo da su među igrama dece zastupljene različite vrste igara, ali da je svaka od njih svedene na svega nekoliko različitih i tipičnih igara i da su, s obzirom na prostor, jasno uočljivi određeni obrasci. U vrtiću su najzastupljenije simboličke imitacije i konstruktorske igre u zatvorenom prostoru. Kod kuće su najzastupljenije funkcionalne igre i igre s pravilima koje podrazumevaju korišćenje lopte na otvorenom prostoru. Na mestima u lokalnoj zajednici (LZ) deca se igraju retko, a kada takva igra postoji - ona je uglavnom karakteristična za dečake i podrazumeva fudbal. Ovakvi rezultati istraživanja upućuju na osiromašenu i nemaštovitu igru dece uzrasta od četiri do sedam godina što može ukazivati na nedovoljno fizički i društveno podsticajnu sredinu.
Theory of mind in children: Preliminary research the role of memory and language abilities as developmental indicators
Authors: Ječmenica Nevena , Drljan Bojana , Buha Nataša
Published: July 2023

Preschool age is a period of fundamental changes in child's ability to explicitly reason about the other people's mental states. The aim of the research was to determine the relationship between the development of theory of mind, working memory and language abilities in children with typical development, aged four to eight years. For the assessment of listed abilities several instruments were used: "Sanja and Ana" False belief task, Backward span task, Verbal memory test, Decision speed test, Toddler grammar and FONT test. The results of the research indicated statistically significant correlations between theory of mind, verbal memory, as well as some aspects of language abilities. However, as a statistically significant indicator of achievement on theory of mind tasks, only verbal memory stands out (p < .05) which together with verbal working memory predicts 26% of the variance of achievement in first-order theory of mind acquisition (F = 9.40, df = 2; p = .00) and 15% of the achievement variance in the total score on theory of mind tasks (F = 4.55, df = 2, p = .01). Research results suggest a close but intriguing relationship between theory of mind, executive functions, and language abilities.
Analysis of Specific absorption rate in the human head model exposed to radiofrequency radiation
Authors: Milošević Marko , Cimbaljević Željko , Živković Milena , Stevanović Nenad , Marković Vladimir , Krstić Dragana
Published: July 2023

As mobile phones have become a necessity in modern society, and there is an increasing number of users of various ages, it is imperative to investigate the impact of mobile phone radiofrequency electromagnetic radiation (RF) on humans. Because the human head is one of the most exposed and sensitive organs in the body, this paper investigated the propagation of the electromagnetic (EM) field through it. Additionally, the Specific absorption rate (SAR) was examined to study how RF radiation affects the human head. A program code using the finite-difference time-domain (FDTD) method was created to simulate the propagation of RF radiation through the six layers that make up the human head (skin, fat, bone, dura mater, CSF, and brain). RF radiation at the following frequencies was investigated: 0.9 GHz, 1.8 GHz, 2.4 GHz, 3.35 GHz, and 4.5 GHz. Values of the thickness and parameters of the layers can also be changed in the program. It was discovered that the majority of the EM energy is absorbed in the skin of the human head.
Gamma spectrometry analysis and health risk assessment of edible liquids
Authors: Cimbaljević Željko , Živković Milena , Milošević Marko , Krstić Dragana , Miladinović Tatjana , Marković Vladimir , Stevanović Nenad
Published: July 2023

Examination of radioactivity in edible liquids is very important because large amounts are taken into the body during the day. This scientific paper presents a comprehensive study on the gamma spectrometry analysis and health risk assessment of edible liquids. The study involved samples of various liquid products such as alcoholic beverages, juices, and milk. Milk is an important part of our regular diet for everyone, from newborns to adults, so we determined the active concentrations of radionuclides for both milk from farms directly and milk bought in a supermarket. The gamma spectrometry analysis was performed using a high-purity germanium detector to determine the concentration of natural and artificial radionuclides. The radioactivity of each sample is presented as the mean value of the measured sample from five different manufacturers. In conclusion, the gamma spectrometry analysis and health risk assessment of edible liquids demonstrated that the concentration of radionuclides in the selected liquid food products was not a major health concern. However, continuous monitoring and evaluation are recommended to ensure that the safety of the products is maintained within the permissible limits.
Influence of cytostatics on relative gene expression in redox status, apoptosis and migration colorectal carcinoma model system
Authors: Pavić Jelena , Živanović Marko , Virijević Katarina , Tanasković Irena , Stanković Vesna , Marić Nebojša , Cvetković Danijela , Filipović Nenad
Published: July 2023

Colorectal cancer is one of the leading causes of mortality worldwide. It is the most common malignancy and there is a need for new approaches in therapies. Surgery, radiation and chemotherapy are the key components of colon cancer treatment. Besides common chemotherapy, alternative therapies are being studied to increase treatment effectiveness and reduce side effects. In this article, colorectal carcinoma cells were treated with chemotherapeutics and relative gene expression was investigated for the genes coding cytoskeleton proteins: CDH1, CTNNB1 and CDH2; for redox status genes: GPX1, GPX2, GPX3, GPX4, TXNRD1, GSTP1, NFE2L2, NFKB1, HIF1A; and for apoptosis genes: CASP3, CASP8, CASP9, FAS, BCL-2 and BAX. The results of our research showed that some concentrations of chemotherapeutics increased the expression of certain genes. Molecular alterations that lead to colorectal cancer can determine appropriate and effective treatment - chemotherapeutics, as well as the design of direct therapeutic targets.
Assessing the impact of heavy metals and antibiotics on bacterial isolates from wastewater treatment plant
Authors: Ćirković Katarina , Ostojić Aleksandar , Đilas Milan , Radojević Ivana
Published: July 2023

The microorganisms isolated from water samples at the wastewater treatment facility Kruševac (Serbia) were screened for resistance to heavy metals and antibiotics. Isolates were identified using morphological and biochemical tests, as well as MALDI-TOF. The resistance to heavy metals was evaluated by determining the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) using the microdilution method. The minimal inhibitory concentration and disc diffusion methods were used to assess antibiotic resistance. Isolates were identified as Morganella morganii PMFKG-K1, Klebsiella oxytoca PMFKG-K2, K. oxytoca PMFKG-K3, K. oxytoca PMFKG-K4, Serratia liquefaciens PMFKG-K5, S. liquefaciens PMFKG-K6, Escherichia coli PMFKG-K7, and Bacillus cereus PMFKG-K8. The obtained results indicated that most isolates in planktonic form showed resistance in the presence of heavy metals such as Pb2+ , Zn 2+ , Cu2+ , and Mn2+ , but showed sensitivity in the presence of Cd2+ , Hg2+ , and Cr6+ and antibiotics. All isolates exhibited desirable characteristics for potential use in bioremediation.
Updating knowledge on the distribution of red algae (Rhodophyta) in Serbia (Southeast Europe)
Authors: Rakonjac Aleksandra , Simić Snežana
Published: July 2023

Freshwater red algae (Rhodophyta) were surveyed in Serbia by examining 411 localities of 196 springs, streams and rivers during 2017-2022. A total of 80 new records of algae were made: species of the genera with Batrachospermum-like morphology (18), Hildenbrandia rivularis (30), Lemanea sp. (1), L. fluviatilis (2), Paralemanea annulata (15), P. catenata (11) and P. torulosa (3).