bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the Diagnostic and Prognostic potential of BMP Pathway and Hypoxia-inducible Factors in Glioblastoma Multiforme
Authors: Yazdani Behnaz , Sichani Adel Rezvani
Published: April 2024

Objective
Glioblastoma Multiforme (GBM) is a devastating neoplastic growth affecting the brain, with a dismal prognosis. The underlying diagnostic and prognostic potential hypoxia-inducible-factors and BMP pathway in this devastating malignancy remains poorly understood, lacking compelling preventive strategies.
Methods and materials:
A bioinformatic study was conducted using integrative bioinformatics techniques for the analysis of GBM count data, which were obtained from the Cancer Genome Atlas (TCGA) database and underwent normalization and differential expression analysis (DEG). Gene Set Enrichment Analysis (GSEA), Differential gene expression analysis, and correlation analysis using Pearson method were conducted for the genes involved in the BMP pathway. Gene Ontology and Protein-protein interaction analyses were employed. Survival analysis and Receiver Operating test (ROC) were also performed to identify potential prognostic and diagnostic biomarkers.
Results
The results revealed that the expression levels of EPAS1, HIF3A, CHRDL1, NOG, BMP6, and AHSG genes did not exhibit a statistically significant difference between GBM cancer samples and normal tissue samples. Further DEG analysis indicated that the majority of genes from the BMP pathogenesis were significantly downregulated in GBM cancer samples and a positive correlation was observed between the expression levels of EPAS1, BMPR2, and MAPK1 genes. the Top DEGs were correlated with specific pathways, such as the TGF-beta signaling pathway, pathways in cancer, and the cell cycle. By ROC test we identified the best diagnostic biomarkers for GBM and SMURF1 gene is predicted to have significant prognostic capability.
Conclusion
These findings highlight the possible utility of these genes as promising diagnostic and prognostic biomarkers for the early detection of GBM.
Sustained effect of prasinezumab on Parkinson’s disease motor progression in the open-label extension of the PASADENA trial
Authors: Pagano Gennaro , Monnet Annabelle , Reyes Adriana , Ribba Benjamin , Svoboda Hanno , Kustermann Thomas , Simuni Tanya , Postuma Ronald , Pavese Nicola , Stocchi Fabrizio , Brockmann Kathrin , Smigorski Krzysztof , Gerbaldo Valentina , Fontoura Paulo , Doody Rachelle , Kerchner Geoffrey , Brundin Patrik , Marek Kenneth , Bonni Azad , Nikolcheva Tania
Published: April 2024

The PASADENA study is an ongoing Phase II, multicenter, randomized, double-blind, placebo-controlled trial evaluating the safety and efficacy of intravenous prasinezumab, administered every 4 weeks, in early-stage Parkinson’s disease (PD). During the double-blind study period, prasinezumab-treated individuals showed less progression of motor signs (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] Part III). We evaluated here whether the effect of prasinezumab on motor progression, assessed as change in MDS-UPDRS Part III in OFF- and ON-state, and MDS-UPDRS Part II scores was sustained over 4 years from the start of the trial. We compared participants enrolled in the PASADENA open-label extension (OLE) to an external comparator arm derived from the Parkinson's Progression Markers Initiative (PPMI) observational study. Both PASADENA delayed- (n = 94) and early-start (n = 177) groups showed a slower decline (less increase in score) on MDS-UPDRS Part III in OFF- (-51% for the delayed-start group and − 65% for the early-start group) and ON-state (-94% for the delayed-start group and − 118% for the early-start group), and on MDS-UPDRS Part II (-48% for the delayed-start group and − 40% for the early-start group), compared with the PPMI external comparator (n = 303). This exploratory analysis, which requires confirmation in future studies, suggests that the effect of prasinezumab in slowing motor progression in PD may be sustained long-term.
Digitalization Of Marketing as Innovation Tool of Customers’ Evaluation
Authors: Parkhomenko Nataliia , Starchon Peter , Vilcekova Lucia , Olsavsky Frantisek
Published: April 2024

This paper analyses the digitalization of museum marketing as an innovative tool for customer evaluation. The content analysis of digital tools created by the most visited museums in the world on social networks such as Facebook, Twitter and Instagram were carried out. To obtain statistical information about the pages of museums in social networks, the social media analytics and management tool Fanpage Karma was used. According to the selected indicators, Fanpage Karma filters the rating of the networks’ current strongest content. The correlation between the number of museum visits and indicators showing the interaction of the museum with visitors using social networks, such as the number of fans, the page performance index, the number of posts per day, the growth rate of followers, post interactions, and the number of total reactions and comments, was evaluated. The aim of this paper is to analyse the impact of museum marketing digitalization processes on museum visits by tourists and, as a result, the economic development of the museum business. To monitor the digitalization strategy of the museum’s marketing activities, a mixed approach based on qualitative and quantitative analysis was used. Multivariate analysis was carried out to determine the relationship between museum attendance and the interaction between museums and subscribers in social networks. It has been proven that the introduction of digital technologies in museum marketing can attract visitors and put the institution at the new informational level. The number of museum visits and the number of fans, the number of posts per day, interactions, and the number of reactions and comments are the same across all social networks. The paper allows us to know the potential audience of the museum and its needs and requests and to predict the interests of certain categories of museum visitors. The scientific novelty and originality of the research consists of the use of digital marketing tools for evaluating their influence on client behaviour. The results of the study may be useful for the development of monitoring systems and strategic management of marketing when evaluating the behaviour of consumers on the content of social networks at enterprises in various industries.
The Relationship Between Consumer Life Orientation and Panic Buying Behavior in the COVID-19 Pandemic Process
Authors: Cakirkaya Murat , Kocyigit Murat
Published: April 2024

The impact of COVID-19, which was declared a pandemic in 2020, has greatly decreased. However, although its lethal effect on humans is low, different variants continue to emerge. The purpose of this research was to examine the relationship between consumer life orientation and panic buying behaviour during the COVID-19 pandemic. Additionally, the effect of consumer life orientation on panic buying behaviour through buying impulsivity, temporal focus, and purchasing risk perception variables was also investigated. In this research, a relational research technique was used to examine the relationship between consumer life orientation and panic buying behaviour. The universe of the research consists of consumers who shop in the retail sector. Since it was not possible to reach all of these consumers within the scope of the research, the research was carried out with the convenience sampling method. In this context, using the data of the online study with n=422 participants, the relationships between the variables were tested, and the hypotheses put forward were theoretically tested. In this research, a questionnaire explaining the latent variables of consumer life orientation, buying impulsivity, temporal focus, purchasing risk perception and panic buying behaviour was used. In the analysis of the data, descriptive statistics, confirmatory factor analysis (CFA) and structural equation modelling (SEM) were performed using statistical package programs. In line with the research findings, it has been determined that the consumer life orientation variable has a statistically significant and moderate effect on panic buying behaviour through buying impulsivity and purchasing risk perception variables (p<0.001) during the COVID-19 pandemic. On the other hand, it was determined that consumer life orientation did not have a statistically significant effect on panic buying behaviour through the temporal focus variable (p>0.005). These findings, which show that life orientation affects purchasing impulsivity and panic buying behaviour through purchasing risk perception, show that there is a positive correlation between consumers’ life orientations and purchasing tendencies. In other words, the COVID-19 Pandemic process caused a change in the life orientations of consumers in psychosocial terms; emotions such as stress, anxiety and uncertainty triggered panic buying behaviour. In similar studies to be conducted in this direction, the relationship between consumer decision-making styles and panic buying behaviour can be examined. In addition, research can be conducted on consumer groups other than the retail sector.
The Development of the E-Commerce Market in Poland in the Conditions of Intensification of Migration Processes
Authors: Zatonatska Tetiana , Fareniuk Yana , Juscius Vytautas , Martinkiene Jurgita , Maksymchuk Olena
Published: April 2024

The impact of the war in Ukraine and migration has affected the e-commerce markets of the recipient countries, presenting both opportunities, in the form of an increased consumer base, and challenges, such as the lack of a clear development vision. This paper aims to investigate the influence of migration processes on the development of e-commerce in Poland and examine the feasibility of using forecasting methods by e-commerce companies under these conditions for future activity planning. To fulfill the research objective, the following tasks were addressed: investigating the current state of e-commerce development influenced by migration processes; exploring modern migration processes and their impact on global economies; assessing the impact of migration from Ukraine on the Polish market; and analyzing a Polish online store to develop a model for forecasting data and planning activities under the influence of migration processes. To achieve this goal, three models were constructed: a multiple regression model to assess the level of migration processes’ influence on e-commerce; a neural network to forecast sales for a Polish e-commerce store; and cluster analysis to identify clusters of goods most affected by migration processes. The study analyzed the nuances of modern migration processes and assessed the reverse effect of migration as a driver of e-commerce development. Migration stimulates e-commerce by altering consumer behavior and logistics routes, increasing exports and imports, and fostering the spread of digital entrepreneurship. Using data from a Polish online store, the study modeled the impact of market changes on the company’s operations and identified the most significant factors. Thus, the analysis explored the impact of migration on e-business in Poland through constructed models. Regression analysis revealed that migration processes have contributed to the development of the Polish online store’s sales, thanks to the increase in migrant consumers and rising price levels. A neural network was developed with machine learning, incorporating macroeconomic and demographic factors into its forecasting typology. Cluster analysis was employed to examine the online store’s assortment, identifying clusters by sales volume and migrants’ influence. The analysis determined that, following the onset of the migration movement, categories experiencing a surge in demand from refugees, such as baby food products, appliances, telephones, furniture, and communication devices, saw the most significant growth.
Side of chute and handedness does not affect the sensitivity of Tritrichomonas foetus sample collection in bulls
Authors: Koziol Jennifer H. , Gibbons Pippa M.S. , Fritzler Jason M. , Boggan SaraBeth
Published: April 2024

Tritrichomonas foetus, a sexually transmitted pathogen of cattle, continues to plague the cattle industry despite control efforts. Pre-analytical diagnostic considerations such as sample collection and sample handling continue to be a shortcoming in the diagnosis of T. foetus in bulls. Preputial scraping is the most common means of sample collection. Previous studies have shown an effect of handedness of the sample collector and the side of the chute that collection was made from as factors that affected the diagnostic sensitivity of the test. The aim of our study was to determine if being right or left-handed and the side of the chute the collection occurred on impacted the diagnostic sensitivity or specificity. Eleven sexually mature bulls naturally infected with T. foetus were enrolled in a 2-factor cross-over study design. Samples were taken once a week for 8 weeks by either a right-handed or left-handed veterinarian from either the left then the right side of the chute or right then left side of the chute, only using their dominant hand to make the scraping motion used to obtain the sample. Utilizing a 2-way ANOVA, we found no significant difference in the chance of acquiring a positive sample per bull (P = 0.8708) regardless of whether the sample was taken from the right or left side of the chute and regardless of dominant hand. In conclusion, using current RT-qPCR methods, the authors found no effect of handedness or side of chute on diagnostic sensitivity.
survey of Mississippi cow-calf producers regarding factors associated with veterinarians performing bull breeding soundness evaluations and/or pregnancy diagnosis
Authors: Gunderson Todd G. , Jumper W. Isaac , King E. Heath , Huston Carla L. , Smith David R.
Published: April 2024

Reproductive efficiency is a major driver of profitability in cow-calf herds, yet many beef producers do not hire veterinar­ians to perform services intended to improve reproductive ef­ficiency such as bull breeding soundness evaluation (BSE) or pregnancy diagnosis. The objective of this study was to deter­mine reasons Mississippi cow-calf producers do or do not hire veterinarians to perform these services. Anonymous surveys were mailed to 1,500 randomly selected members of the Missis­sippi Cattlemen’s Association. Multivariable logistic regression was used to test respondent characteristics for association with outcome variables (e.g., respondents hire a veterinarian for BSEs and/or pregnancy diagnosis). Of 414 returned surveys, 397 (96%) qualified for analysis for an overall response rate of 26%. Of respondents that answered the respective ques­tions, 155/386 (40%) hire a veterinarian for BSEs, and 103/392 (26%) hire a veterinarian for pregnancy diagnosis. Of 396 re­spondents, 229 (58%) indicated they had some form of a defined breeding season. The most common reasons for not hiring a veterinarian were lack of time/help (82/202, 41%) for BSEs and cost (91/248, 37%) for pregnancy diagnosis. On in­ferential analysis, the factors positively associated with hiring a veterinarian for BSEs were having a defined breeding season (OR = 6.8, 95% C.I. = 4.1-11.1) and raising seedstock cattle (OR = 1.7, 95%C.I. = 1.0-13.3). The only factor positively associ­ated with hiring a veterinarian for pregnancy diagnosis was having a defined breeding season (OR = 4.2, 95%C.I. = 2.5-7.3). Management style and operation type influenced producers hiring a veterinarian for BSEs and pregnancy diagnosis.
Mechanically-driven stem cell separation in tissues caused by proliferating daughter cells
Authors: Krämer Johannes C. , Hannezo Edouard , Gompper Gerhard , Elgeti Jens
Published: April 2024

The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth, the regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue steady-state are still poorly understood. Here, we develop a computational model that incorporates basic assumptions of stem cell renewal into distinct populations and mechanical interactions between cells. We find that the model generates unexpected dynamic features: stem cells repel each other in the bulk tissue and are thus found rather isolated, as in a number of in vivo contexts. By mapping the system onto a gas of passive Brownian particles with effective repulsive interactions, that arise from the generated flows of differentiated cells, we show that we can quantitatively describe such stem cell distribution in tissues. The interaction potential between a pair of stem cells decays exponentially with a characteristic length that spans several cell sizes, corresponding to the volume of cells generated per stem cell division. Our findings may help understanding the dynamics of normal and cancerous epithelial tissues.
The Influence of Parental Psychological Control on Social Anxiety of College Students: Mediating effects of self-differentiation and self-differentiation controlled by social support
Authors:   Korean Association of Family Therapy, Kim Ki-Ryang , Jeon Hye-Seong
Published: April 2024

Objectives: This study was conducted to understand the mediating effect of self-differentiation and the mediating effect of self-differentiation controlled by social support in the effect of the the mother's psychological control on the social anxiety of college students. Methods: A survey was conducted on 541 college students enrolled in universities in the Seoul metropolitan area, excluding 53 with insufficient data; and 488 surveys were used for analysis. Results: The main results are as follows. First, the higher the mother's psychological control, the lower the self-differentiation and social anxiety; and the higher the self-differentiation and social support, the lower the social anxiety of college students. Second, in the relationship between the mother's psychological control and the college student's social anxiety, a mediating effect of self-differentiation controlled by self-differentiation and social support appeared. Conclusions: Through these results, it was confirmed that the promotion of self-differentiation and social support is useful for college students experiencing high social anxiety due to the mother's high psychological contro
A Systematic Literature Review on Family Interventions for Schizophrenia in Korea Over the Last Three Decades: Focusing on theoretical perspectives
Authors:   Korean Association of Family Therapy, Lee Sun Hae , Kang Yujin
Published: April 2024

Objectives: This study aimed to conduct a literature review on family interventions for schizophrenia and to propose future directions and implications for research and practice. Methods: The authors searched academic journal articles published from the 1990s to 2023 in Korea and selected a total of 24 studies for analysis. We identified the theoretical perspectives adopted by each study and conducted a systematic review of intervention content and key outcomes. Results: The results revealed that, apart from a few systemic and empowerment-based approaches, the majority of interventions focused on family psychoeducation based on vulnerability-stress theory to reduce family stress and enhance coping skills. In addition, there is a need for a close examination of epistemological foundations and effectiveness to ensure a clear grasp and implementation of family intervention principles. Conclusion: Based on these findings, it's crucial to diversify the options for family intervention from a theoretical standpoint to adequately address the varied needs of families with schizophrenia.
Family Therapy Case Study for Emerging Adults with Panic Disorder
Authors:   Korean Association of Family Therapy, Yoon Young-Hee , Park Tai-Young , Lee Seung-Hun , Kim Yelim , Yu Sung-Ji , Lee Yunseok
Published: April 2024

Objectives: This study explores the factors that influenced the development of panic disorder, the therapist's interventions, and the effectiveness of family therapy interventions, focusing on three family therapy cases applied to Bowen's family system theory and MRI communication model for three panic disorder clients in emerging adulthood. Methods: Data—therapy notes, recordings, and transcribed documents—were first coded and then pattern coded through continuous comparative analysis to derive the final categories. The results are presented in a matrix and network. Results: The study findings were as follows. First, two types of factors influenced panic disorder: triggering factors and latent factors. Second, therapeutic interventions encompassed setting treatment goals, exploring the family of origin, promoting insight, and encouraging behavioral change. Third, the outcomes of family therapy intervention were marked by enhanced understanding among family members, positive changes in communication patterns, and a reduction in panic attack symptoms. Conclusions: These findings suggest that family therapists working with emerging adults experiencing panic disorder should address parenting styles, communication patterns among family members, and transference from unresolved emotional issues with the family of origin.
Recommendations for topical antimicrobial therapy of inflammatory diseases of the middle ear based on the results of evidence-based clinical study
Authors: Ovchinnikov A. Yu. , Miroshnichenko N. A. , Nikolaeva Yu. O.
Published: April 2024

Introduction. In conditions of widespread resistance of pathogens to traditional antimicrobial drugs, active attention is paid to the development of topical antimicrobial drugs for the effective treatment of inflammatory pathology of the middle ear.

Aim. To study the efficacy and safety of a new dosage form of the drug Dioxydin® (2.5 mg/ml ear drops) in the treatment of patients with acute purulent otitis media and exacerbation of chronic purulent otitis media in comparison with ear drops containing 0.3% ciprofloxacin solution.

Materials and methods. A multicenter randomized comparative clinical trial included adults with acute purulent otitis media or exacerbation of chronic purulent otitis media and during 6 face-to-face visits (days 1st, 3rd, 6th, 9th, as well as a therapy completion visit and a follow-up visit), the effect of drugs was evaluated according to examination, otoscopy, microbiological and audiometric examinations. Safety was assessed by the frequency of adverse events and the results of blood, urine tests and vital signs.

Results. The achievement of the primary criteria was evaluated among 164 participants randomized into 2 groups: the proportion of patients with no indications for systemic antibacterial therapy at Visit 2 and with no ear pain at Visit 4, Dioxydin® ear drops had no less effectiveness than the comparison drug (64.6 and 89.9% versus 68.3 and 87.3%, respectively). In terms of the frequency of elimination of the pathogen and improvement of air conduction, the compared drugs also had no statistically significant differences, and according to some secondary criteria, Dioxydin® significantly exceeded 0.3% ciprofloxacin solution (the proportion of patients with a pronounced decrease in pain and congestion in the ear, as well as hyperemia of the eardrum). According to the safety criteria, the compared drugs had no significant differences.

Conclusions. The results of the study confirmed the high efficacy and safety of Dioxydin® ear drops in the treatment of otitis media in adults.
Placental Vimentin Expression in Preeclampsia and Gestational Diabetes Mellitus
Authors: Asir Fırat , Oglak Suleyman Cemil , Korak Tugcan , Tas Fatih , Yilmaz Mehmet , Erdemci Fikri , Sahin Firat , Ayaz Hayat , Yilmaz Emine Zeynep , Bolluk Gokhan
Published: April 2024

OBJECTIVE: This study investigated vimentin expression in placentas of patients with preeclampsia and gestational diabetes mellitus (GDM).
STUDY DESIGN: Placentas of preeclamptic women (n=25), women with GDM (n=25), and control cases (n=25) were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recorded. Vimentin immune activity was analyzed in the placental sections with immunohistochemistry. Sections were imaged and analyzed under a light microscope. A semiquantitative measurement was done between groups by comparing the Vimentin signal and significance was calculated. Network construction and pathway enrichment analysis were conducted using Cytoscape (v3.10.1) and ShinyGO, respectively.
RESULTS: Vimentin expression was high in the placental sections of the control group. The preeclampsia group showed positive Vimentin expression in cytotrophoblast and syncytiotrophoblast cells and connective tissue of placental villi in the preeclampsia group. Vimentin expression was generally recorded as negative in placental villi, fibrinoid substances, and connective tissue cells in the GDM group. Bioinformatic analysis showed that the AGE-RAGE signaling pathway and cancer-related pathways were mainly observed in Vimentin-associated pathways, which finally activate inflammatory pathways in both preeclampsia and GDM.
CONCLUSION: Vimentin expression patterns in placental tissue sections reveal nuanced regulatory mechanisms, emphasizing the need for further exploration into the functional roles of vimentin in placental physiology and pathology.
The Mystery of Lomonosov’s Date of Birth
Authors:   St. Petersburg State University, Krotov Pavel A.
Published: April 2024

Officially, the date of birth of M. V. Lomonosov is now considered to have been November 8 (19), 1711, although it is stipulated that this is a conditional date since the metric book where it was recorded was lost in the 18th century. This date of birth was chosen in 1911 by the Academy of Sciences for the jubilee celebrations of the 200th anniversary of the birth of the luminary of science, according to the assumption of Academician M. I. Sukhomlinov (1896). The author of the article found out that the now accepted 1711 year of birth of Lomonosov is the result of calculations by his colleague at the Imperial St. Petersburg Academy of Sciences, Academician Ya. Shtelin (1709–1785), made after the death of Lomonosov in 1765. An analysis of all previously known and newly identified sources and all existing versions of his birth date allowed us to put forward a new version. The author of the article shows that Lomonosov, in certain circumstances, whether he was ordained a priest or appointed to the position of professor, it turned out to be advantageous to exaggerate his too undignified age. The conducted research allowed to challenge the assumption of Ya. Shtelin (1765) about the birth in 1711 of the great Russian scientist-encyclopedist, poet-innovator Lomonosov and based on the study of reliable documentary materials (the certificate of the metric book about his death, the memoirs of the professor himself in the transfer Ya. Shtelin) to assert that he was born in 1714. It probably happened days earlier or on the very day of the memory of St. Michael Malein on July 12 (23), or on the eve or on the very day of the memory of St. Archangel Michael on November 8 (19), 1714. Both versions should now be considered equivalent.
Generalized Anxiety Disorder among Paediatricians During the COVID-19 Pandemic
Authors: Aziz Shaffaq , Shabir Sadia , Noor Misbah , Samaa Asvar , Aslam Samia , Hamid Muhammad Haroon
Published: April 2024

Background: COVID-19 pandemic has put healthcare professionals at risk of developing mental health issues. Primarily, because of their increased chances of being affected and fulfilling their job commitments despite insufficient knowledge about the new disease and its management. Hence, it is essential to assess the burden of such mental health issues amongst healthcare providers.
Objective: To determine the frequency and severity of generalized anxiety disorder among paediatricians during the COVID-19 pandemic.
Methods: Cross-sectional observational study conducted in Department of Paediatrics (unit 1), King Edward Medical University/ Mayo Hospital Lahore, duration of 03 months. After IRB approval, an online survey form was developed based on GAD-7 Scale as an assessment tool for assessing anxiety among paediatricians. A survey form was dispersed using social media to pediatricians of different ages and working statuses. The responses were recorded and assessed using SPPSS. Quantitative variables (age, GAD-score) were summarised as mean and standard deviation. Qualitative variables (gender, place of work, individual GAD- component score) were summarised as frequency and percentages.
Results: A total of 147 responses were received, out of which 13 were excluded. The remaining 134 were analysed through SPSS 26. Out of these, 106 (79.1%) turned out to be suffering from new-onset anxiety. Amongst these 106 paediatricians, 69 (65.1%) were females, and 37(35.9%) were males (p-value 0.013). The severity of anxiety was mild, moderate and severe in 62 (46.3%), 37 (27.6%) and 7 (5.2%) of paediatricians, respectively.
Conclusion: More than three-fourths of paediatricians had higher GAD 7 scores   during the COVID-19 pandemic suggesting generalized anxiety disorder.
Perspectives of Stakeholders on the inclusion of Personality Assessment in the Admission Policies of Medical Colleges: A Qualitative Study
Authors: Usman Javeria , Khan Rehan Ahmed , Yasmeen Raheela , Mukhtar Khadijah
Published: April 2024

Background: Joining the health care force as a doctor is a dream that flourishes in the minds of majority of youngsters in Pakistan, making the admission process highly competitive. Currently, our admission criteria only caters the knowledge domain of the applicants while research argues that personality of the candidates should also be considered when selecting the cream of the nation for one of the most critical profession of medicine.
Objective: The objective of this research was to investigate stakeholders’ perspectives on the incorporation of personality assessment as a component of the admission requirements for medical colleges in Pakistan.
Methods: An exploratory qualitative study was conducted using a multi-center approach, where participants from three different stakeholder groups involved in medical college admissions in Pakistan (Governing body members, experienced academic staff, and medical scholars) were interviewed. The analysis method used was thematic analysis.
Results: The stakeholders reached a consensus that the current admission criteria need to be revised, although opinions were varied regarding the inclusion of personality assessment in the admission process. The stakeholders identified conscientiousness, agreeableness, neuroticism, extraversion, and openness to experience as the key personality features to be evaluated for medical college admissions, in descending order of importance.
Conclusion: This study highlighted the need to revise and expand the existing admission criteria, while also revealing a diversified feedback to the proposal of introducing personality appraisal as part of the medical college admission standards as they may pose significant obstacles.
Recetario ancestral ilustrado
Authors: Larraín América , Muñoz Adriana , Cabrera Andrés , Camila María
Published: April 2024

Este recetario es resultado de un trabajo conjunto entre la Universidad Nacional de Colombia y la comunidad arhuaca del resguardo de Jimaín, en el marco del proyecto de extensión solidaria, relacionado con producción agroacuícola. Buscando garantizar la continuidad de las iniciativas que se gestaron allí y que la comunidad pudiera integrar de manera armónica el consumo de peces en su dieta, realizamos una evaluación previa de las posibilidades reales de apropiación de estas prácticas, tanto en su dimensión técnica, ligada a la cría y levante de los peces, como en la incorporación de esta proteína en sus dietas. Por ello, decidimos invertir en un conocimiento más profundo de las prácticas alimentarias arhuacas a través de entrevistas y talleres, donde identificamos comidas y preparaciones recientes y antiguas que son importantes para la comunidad.

Aunque trabajamos con foco en la apropiación y difusión del conocimiento piscícola, el recetario no se limita a recetas con pescado, sino que se extiende a otros alimentos cotidianos y significativos, resaltando aquellas preparaciones que hacen parte de la gastronomía local y de la identidad regional y étnica, buscando fortalecer las tradiciones agrícolas propias. Sin que se trate de una recopilación exhaustiva de la gastronomía de la Sierra, aquí quisimos contribuir al registro de algunas historias, conocimientos, técnicas y prácticas cotidianas que sostienen el día a día de los habitantes de este territorio.
La batalla de Ciénaga de 1820 y la independencia del Caribe colombiano
Authors: Viloria Joaquín , Viloria Joaquín , Pita Roger , Rodado Carlos , Lastra Roberto , Isabel Amelia
Published: April 2024

El 10 de noviembre de 2020 se cumplieron los doscientos años de la batalla de Ciénaga y la liberación de la ciudad de Santa Marta. Este enfrentamiento fue uno de los más sangrientos y decisivos de la independencia de Colombia, pero así mismo uno de los menos estudiados y por tanto menos conocidos en la historiografía del país. El propósito de esta publicación es contribuir en parte a la recuperación histórica de la batalla de Ciénaga, acontecimiento fundamental en la consecución de la independencia definitiva de las provincias del Caribe colombiano. También se busca dimensionar este hecho en el campo de la disputa simbólica por la memoria de la independencia de Colombia. Por lo tanto, este libro promueve dicho episodio como objeto de estudio y como componente de la enseñanza escolar con mayor amplitud, más allá de los hitos fundacionales de la emancipación política impulsados por la historiografía convencional como son el 20 de julio y el 7 de agosto. La batalla de Ciénaga fue la antesala para la liberación de Santa Marta, donde el ejército patriota derrotó a los realistas, con un saldo trágico de muertes. También se estudia en el contexto del Sitio y toma de Cartagena y la batalla naval del Lago de Maracaibo, ocurridas entre noviembre de 1820 y julio de 1823.
Impact of Interest value, Social, and Economic Factors on the Application Intentions towards Gojek Startup among Job Seekers in the Jabodetabek Region
Authors: Vanessa Vanessa , Hidayat Wanda Gema Prasadio Akbar
Published: April 2024

The attractiveness of employer branding strategies, particularly in startups such as the Indonesian fintech company Gojek, plays a pivotal role in drawing Generation Z's and Millennials' attention. This research aimed to empirically examine the influence of interest, social, and economic values on the intention to apply to Gojek among job seekers in the Jabodetabek area. Utilizing a quantitative research design, the study adopted a non-probability judgment sampling technique to select participants, surveying 150 Generation Z and Millennial job seekers. The data collected were analyzed through SPSS version 25. The outcomes indicated that the decision to apply is influenced concurrently by interest values, social values, and economic values. Specifically, the analysis revealed that interest value significantly enhances application intentions (t-count > t-table: 4,340 > 1,655), as do social values (t-count > t-table: 2,290 > 1,655) and economic values (t-count > t-table: 2,488 > 1,655). The study underscores the necessity for Gojek to bolster its value propositions, especially by fostering promising career paths aligned with the valued attributes and economic benefits, which are crucial factors in attracting job applicants. These insights advocate for a strategic emphasis on nurturing an employer brand that harmonizes with the aspirational and pragmatic expectations of contemporary job seekers, thereby enhancing their inclination to pursue employment opportunities within Gojek.
Influence of Capital Adequacy Ratio, Credit Risk, Market Risk and Financial Distress Indicator towards Stock Return
Authors: Juliandari Millenia , Yoewono Harsono
Published: April 2024

The research objective is to the influence of capital adequacy ratios, credit risk, market risk, and financial distress indicators on stock returns. The sample uses a saturated sampling method. The data used is secondary data collected using the documentation method. Independent variables include indicators of capital adequacy ratio, credit risk, market risk, and financial distress with the dependent variable being stock returns. The analysis uses multiple regression. This research found that: capital adequacy ratio, credit risk, market risk, and financial distress have no effect on stock returns.
Resilience of Islamic Equities against Uncertainty
Authors: Canggih Clarashinta , Nurafini Fira , Wakhidah Erfaniah Putri
Published: April 2024

This research aims to analyze the resilience of Islamic Equities against the economy and non-economic uncertainty within the past decades. Islamic Equities are represented by the developed, emerging, and frontier market S&P BMI Shariah Index. The World Uncertainty Index and economic policy uncertainty measure uncertainty. This paper uses a time-series approach utilizing the Vector Autoregressive (VAR) model to estimate the resilience of Islamic equities based on quarterly stock return, the World Uncertainty Index, and the Economic Uncertainty Index from 2013 to 2023. It shows that Islamic equities are resilient to economic uncertainty but not non-economic uncertainty.
Exploring Attitude and Behavior Towards Shopping at Zero-Waste Store: An intra-personal and external factors approach
Authors: Setiawan Monica Hody , Rizkalla Nosica
Published: April 2024

Many retailers have switched their business model to zero-waste retail to preserve the environment. However, many consumers still feel unfamiliar with this system and thus feel reluctant to continue shopping at zero-waste retail. This study employed the internal-external approach to comprehend consumers' intentions to shop at zero-waste stores. A total of 125 responses were collected and analyzed in SEM with Lisrel. This study found that environmental knowledge and reputation positively impact attitudes toward shopping in zero-waste stores, which in turn would also affect purchase behavior toward zero-waste stores.
Intrinsic Motivation, Life Satisfaction and Happiness: Students at higher learning institution in Malaysia
Authors: Mohd Fauzi Muna Wadhiha , Hussein Norashikin , Mohamed Razali Murni Zarina , Anwar Nur Aizureen , Omar Norhayati
Published: April 2024

Happiness is currently one of the primary indicators of social progress in modern society, particularly among students at higher learning institutions. The study examines the relationship between intrinsic motivation, life satisfaction, and happiness. 285 business faculty students at a higher learning institution in Malaysia enrolled in a bachelor's degree programme received online surveys. The results demonstrated a positive and significant relationship between happiness and the two independent variables of intrinsic motivation and life satisfaction. This study sheds light on how offering extracurricular activities can boost students' pleasure in higher learning and improve students’ intrinsic motivation and life satisfaction
Analysis of the Effect of Effort Expectancy, Social Influence, Hedonic Motivation, Price Value, Habit, and Flow on MMORPG’s Intention to Play
Authors: Samudera Marvella , Lestari Elissa Dwi , Kurniasari Florentina
Published: April 2024

With more Internet access, MMORPGs have grown in popularity. In Indonesia, the biggest gaming market in Southeast Asia, this genre is less popular. Therefore, studying what inspires Indonesian MMORP users is necessary. The study used a quantitative research design on 221 online gamers who were familiar with MMORPGs but had never played them. The study tested research hypotheses using multivariate linear regression analysis. The study discovered that hedonic motivation, price value, habit, and flow all have a positive impact on one's intention to play MMORPG online games, but effort expectation and social influence have no impact.
Food Waste Management and Awareness: A survey among Bandar Puncak Alam residents’ community
Authors: Mokthar Mohammad Zulfakhairi , Saiful Bahry Farrah Diana , Ahmad Norlela , Mohd. Khir Masrur
Published: April 2024

The escalating food waste issue, notably in Malaysia, prompted this study. The objectives aimed to assess Bandar Puncak Alam residents' knowledge and awareness, understand waste management behaviors, explore current food waste practices, and evaluate concerns about food waste issues. Utilizing questionnaires distributed among 152 residents via convenience sampling, the study revealed robust awareness and commitment to environmental sustainability. However, a notable gap was identified in the understanding of optimal food waste management methods. Despite high awareness levels, there is a need for enhanced education on effective food waste handling in Bandar Puncak Alam.
Adopting Innovations in Agri-Tech Sector for a Sustainable Future
Authors: Abdul Wahab Shazanah , Mat Nor Norzanah , Abd Rashid Amirul
Published: April 2024

The global food chain has been affected by climate change and geopolitical conflicts. To guarantee access to food, food production must be increased as predicted in the next 30 years, the world's population is to surpass 10 billion. This study aims to examine current and future developments in the food industry with a particular emphasis on how agri-tech companies and startups will react. The main purpose is to examine how agri-tech innovations are adopted, to identify the capacity-building requirements for improved data utilization, and to look at the financial and intermediary variables impacting innovation uptake.
Fintech Frenzy: An engaging review of the transforming financial services
Authors: Zakaria Shahsuzan , Abdul Manaf Suhaily Maizan , Amron Mohd Talmizie
Published: April 2024

Advancements, opportunities, and challenges in financial technology (fintech) are comprehensively reviewed in this paper. Fintech, powered by AI and blockchain, revolutionises access to financial services. The narrative review analyses academic databases and industry reports, highlighting fintech themes like mobile payments, peer-to-peer lending, robo-advisors, and blockchain. Opportunities include accessible services, efficiency, and cost savings. However, challenges like cybersecurity, regulation, financial inclusion, resistance to change, and data privacy must be addressed. Responsible and ethical fintech practices are crucial for security, regulation compliance, inclusion, and confidentiality. Fintech's potential to transform finance and enhance lives worldwide is emphasised.
First Responder's Standard Operating Procedure for Employing Drones to Expedite Insurance Claims
Authors: Zulkifli Ahmad Farouk , Muhamat Amirul Afif , Jatmiko Wahyu , Syed Alwi Sharifah Faigah
Published: April 2024

Drones offer cost-effective real-time data collection, payload delivery, and have accelerated various commercial, industrial, and recreational applications. They are commonly used for research, disease transmission monitoring, disaster site assessment, and biohazard monitoring. However, disaster victim insurance claims are hampered by insufficient cooperation between first responders, typically the Civil Defence Department, and the insurance industry. This paper proposes integrating drones into standard operating procedures for disaster victim identification by first responders. Improved collaboration between first responders and insurers can expedite insurance claims, benefiting both parties and disaster victims. Insights are drawn from feedback provided by Civil Defence Department Malaysia's first responders and experienced forensic experts in search and rescue operations
Leveraging Creative Intelligence for Sustainable Customer Relationship Management (CRM) Solutions: Conceptual paper
Authors: Ramli Suriana , Bojei Jamil , Abdul Rahman Normy Rafida , Wong Chee Hoon
Published: April 2024

The study aims to identify critical dimensions of employee creative intelligence and AI CRM systems and explore their impact on service quality and customer satisfaction in customer relationship management (CRM). The advancement of technology and the potential of artificial intelligence (AI) increase customer expectations regarding service delivery. The conceptual framework illustrates that creative intelligence and AI-generated systems significantly impact service quality and customer satisfaction. The findings will help organisations implement CRM service delivery projects by providing employees with the appropriate skills and competencies. The appropriateness of the system is vital towards CRM solutions.
Remote Exercise Training Intervention During the COVID-19 Pandemic: Randomized Controlled Trial
Authors: Philippi Keito F A , Zeier Peter , Brahmer Alexandra , Neuberger Elmo W I , Sandner Magdalena , Hagenah Matthias , Porten Thilo , Lenz Regina , Ochmann David T , Wedekink Florian , Wischhusen Jörg , Lutz Beat , Lieb Klaus , Wessa Michèle , Simon Perikles
Published: April 2024

Background

Societal measures to contain the spread of COVID-19 (eg, lockdown and contact restrictions) have been associated with decreased health and well-being. A multitude of prepandemic studies identified the beneficial effects of physical exercise on both physical and mental health.

Objective

We report on the feasibility of a remote physical exercise intervention and its stress-buffering potential in 2 untrained cohorts: a pre–COVID-19 cohort that completed the intervention in 2019 and a lockdown cohort that started the intervention shortly before pandemic-related restrictions were implemented.

Methods

In a randomized controlled trial, participants were assigned to either an intervention group (IG; pre–COVID-19 cohort: n=7 and lockdown cohort: n=9) or a control group (CG; pre–COVID-19 cohort: n=6 and lockdown cohort: n=6). IG participants received weekly individualized training recommendations delivered via web-based support. The intervention period was initially planned for 8 weeks, which was adhered to in the pre–COVID-19 cohort (mean 8.3, SD 0.5 weeks) but was extended to an average of 17.7 (SD 2.0) weeks in the lockdown cohort. Participants’ health parameters were assessed before and after the intervention: aerobic capacity was measured as peak oxygen uptake (VO2peak) via cardiopulmonary exercise testing. Depressive symptoms were scored via the depression subscale of the Brief Symptom Inventory-18.

Results

Dropout rates were low in both cohorts in the IG (pre–COVID-19 cohort: n=0, 0% and lockdown cohort: n=2, 16.7%) and the CG (pre–COVID-19 cohort: n=0, 0% and lockdown cohort: n=2, 20%). The mean adherence to the training sessions of the IG for both cohorts was 84% (pre–COVID-19 cohort: SD 5.5% and lockdown cohort: SD 11.6%). Aligned rank transform ANOVAs in the lockdown cohort indicated deterioration of VO2peak and depressive symptoms from before to after the intervention in the CG but no longitudinal changes in the IG. Analyses in the pre–COVID-19 cohort revealed significant increases in VO2peak for the IG compared to the CG (P=.04) but no intervention effects on depressive symptoms.

Conclusions

With low dropout rates and high adherence, the remote intervention was feasible for healthy adults under regular conditions and in the face of pandemic-related stressors. Moreover, our results hint at a stress-buffering effect as well as a buffering of a lockdown-induced deconditioning of remote physical exercise interventions in the pandemic scenario, which can be used in future studies to overcome equally stressful periods of life. However, due to limited statistical power, these findings should be replicated in similar scenarios.

Trial Registration

German Clinical Trials Register DRKS00018078; https://drks.de/search/en/trial/DRKS00018078