bluuebunny/crossref_metadata_2025 huggingface dataset:
Borges: literato y filósofo de las paradojas
Authors: Aguirre Román Javier Orlando , Rangel Quiñonez Henry Sebastián
Published: October 2019

el presente texto es una revisión crítica de parte de la obra del escritor argentino Jorge Luis Borges con el fin de evidenciar el talante filosófico de este autor. Para ello se presta especial atención al uso de la noción de infinito y las paradojas que de él resultan. Nuestra conclusión es que, si se va a considerar a Borges como filósofo, se debe concluir que, ante todo, es un “filósofo de las paradojas”. Sobre esta base se puede entender su idealismo escéptico.
Tensiones en torno al cuerpo, el género y el deseo en los Programas de estudio de educación para la afectividad y sexualidad integral de Costa Rica
Authors: Retana Camilo
Published: October 2019

el presente artículo se ocupa de analizar los Programas de estudio de educación para la afectividad y sexualidad integral del Ministerio de Educación Pública de Costa Rica (MEP). Para ello realiza una contextualización, en primer lugar, histórico-normativa y, en segundo lugar, política de dicha directriz educativa. Asimismo, el texto se interesa en estudiar el modo en que distintas agendas condicionan y tensan los contenidos de los Programas. Específicamente, el artículo se adentra en las concepciones del cuerpo, el género y el deseo de los Programas... para mostrar las visiones enfrentadas que implícitamente estructuran tales concepciones. El objetivo, así, es discutir críticamente la Educación Sexual en general, y los Programas de estudio de educación para la afectividad y sexualidad integral en particular, más allá de las posiciones dicotómicas (a favor-en contra) que suelen emplearse para tales efectos.
Una cierta idea de la filosofía:acerca de la recepción y no recepción de Nicolás Gómez Dávila en Francia
Authors: Rabier Michäel
Published: October 2019

la recepción de la obra de Nicolás Gómez Dávila en Francia ha sido muy escasa hasta el momento, sobre todo en el medio universitario. Este problema de la no recepción –más que de la recepción– está ligado no solamente y directamente a una cuestión editorial y/o de traducción, sino a un asunto intelectual y académico que tiene, según nuestra tesis, mucho que ver con la concepción francesa y moderna de la filosofía y a lo que hemos llamado la “anti-filosofía” gomezdaviliana.
La visión de lo sagrado: religiosidad en Hölderlin y Nietzsche
Authors: Valero Sánchez Gerardo José
Published: October 2019

el siguiente artículo se circunscribe dentro de los campos de la Estética y la Filosofía de la Religión. Tiene por objeto central el análisis comparativo, a nivel de la visión de lo sagrado, entre los autores alemanes: Friedrich Hölderlin y Friedrich Nietzsche. Ambos, uno desde el campo de la poesía y el otro de la filosofía, exponen importantes ideas sobre la relación del hombre con el fenómeno religioso (religión-religiosidad) como continuación o superación del mismo. Estos dos enfoques van a influir, de manera notable, en la reflexión filosófica del siglo XX hasta nuestros días.
Evaluación de la hidrólisis alcalina-enzimática para la obtención de colágeno hidrolizado a partir virutas de cuero curtido
Authors: Vallejo Rodríguez Juan Sebastián , Almonacid Jiménez Leidy Yaneth , Agudelo Valencia Rafael Nikolay , Hernández Fernández Javier Adolfo , Ortiz Medina Óscar Leonardo
Published: October 2019

Las virutas de cuero curtido representan el residuo sólido generado durante la etapa de rebajado de cueros como parte del curtido y teñido de pieles, este residuo representa un riesgo al ambiente al momento de su disposición final; por causa del alto contenido de cromo, situación que hace necesario evaluar alternativas para el tratamiento de estos. En el proceso experimental se empleó la hidrólisis enzimática de la viruta para obtener colágeno hidrolizado, las variables o factores de proceso empleadas fueron el pH (8 y 10), tiempos de reacción (11 a 13 horas) y dosis de enzima BLUE G-Dupont internacional (0.00001 kg, 0.0000125 kg y 0.000015 kg). Los resultados experimentales dieron lugar a determinar que las condiciones óptimas para la obtención de colágeno hidrolizado en su mayor contenido fueron: pH 10, dosis de enzima de kg y 12.5 horas de tiempo de reacción para obtener una concentración de colágeno hidrolizado de 1.828 kg/m3 correspondiente a una recuperación del 9.14 % en masa con respecto a la masa de viruta de cuero curtido utilizada para cada ensayo .
The Influence of Discipline on Lecturers’ Motivation and Performance in Indragiri College of Economics (STIE) Rengat
Authors: Ivalaina Astarina  , Hapsila Angga , Fitrio Tomy
Published: October 2019

This research aimed to determine the influence of discipline on motivation, as well on lecturers’ performance, and to discover the influence of motivation on the lecturers’ performance in Indragiri College of Economics (STIE) Rengat. The researchers took the population of the lecturers in Indragiri College of Economic (STIE-I) Rengat. The numbers of the lecturers in Indragiri College of Economics (STIE) Rengat were 34 people. The sampling method of this research was using a saturated sampling technique (census). The data of this research were analyzed by using quantitative method and all obtained data were processed by PLS. The results of this research showed that discipline had significant influence on motivation, as well on the lecturers’ performance; subsequently the motivation had influence on the lecturers’ performance and discipline had influence on the lecturers’performance which was mediated by motivation.
The Effect of Work Motivation on Employees’ Performance Mediated by Job Satisfaction at Pt. Bank Rakyat Indonesia TBK Rengat Branch Office
Authors: Puspa Dewi  , Fikri Khusnul , Fitrioc Tomy
Published: October 2019

The purpose of this study was to analyze the effect of work motivation on job satisfaction, work motivation on employees’ performance and job satisfaction on employees’ performance and the effect of work motivation on employees’ performance mediated by job satisfaction at PT. Bank Rakyat Indonesia (Persero) Tbk Rengat Branch Office. The data were collected by a close questionnaire. The samples were 65 organic employees working at PT. Bank Rakyat Indonesia (Persero) Tbk Rengat Branch Office. These samples were chosen by saturated sampling technique. Then, the data were analyzed by applying SEM (Structural Equation Modeling) analysis which was operated through SmartPLS 3 Application. The results of this study indicated that: (1) Work motivation has a positive and significant effect on employees’ job satisfaction. (2) Work motivation has a positive and significant effect on employees’ performance. (3) Job satisfaction has a positive and significant effect on employees’ performance. (4) Job satisfaction mediates the influence of work motivations on employees’ performance positively and significantly.
Bi(NO3)3•5H2O-catalyzed Mannich Reaction: A Potent Catalyst for Synthesis of β-Aminocarbonyl Compounds
Authors: YAŞA Hasniye , DEMİR Kübra
Published: October 2019

Biologically active
compounds containing nitrogen, natural molecules and drugs are important for
organic synthesis. Mannich reaction is one of the most common methods used for
the synthesis of these compounds. Bi(NO3)3 was used as an
efficient catalyst for the one-pot three-component Mannich reactions of ketones
with different aromatic amines and aromatic aldehydes at room temperature. It
is a good method to prepare β-amino carbonyl compounds in excellent yield. The
high efficiency using simple starting materials and a catalytic amount of a
reusable catalyst is especially noteworthy.
HYGIENIC ASPECTS OF CHRONIC FATIGUE AND AGING
Authors: Sorokin Genady A. , Shilov V. V.
Published: October 2019

The aim of the study was to establish relations between the acute and chronic fatigue of workers, and between chronic fatigue and age dynamics of indices of health. In 859 women, white-collar workers, with normal fatigue at work of various degree and different physiological labor intensity there was determined an annual gain of professional risks (GPR): syndromes of motor, visual, and non-specific chronic fatigue; indices of the physical performance; morbidity with temporary disability. During the year the health is deteriorating both in 59% of women who are very tired at work, and 63% of women with chronic fatigue syndrome. Under a high level of the physiological intensity of labor GPR increases by 2 times for diseases of the cardiovascular system and by 2.2-times for the disorders of the musculoskeletal system. For hygienic evaluation rate of aging working in harmful conditions, there are required values of age population trends in health indices observed in favorable habitat, without the harmful effects of professional and non-professional factors.
THE IMPACT OF BROADBAND ELECTROMAGNETIC PULSES ON THE COGNITIVE REACTIONS OF WHITE MICE
Authors: Afanasev Andrey S. , Zibarev E. V. , Kalyada T. V.
Published: October 2019

There were executed studies to assess the impact of broadband pulsed electromagnetic radiation on the central nervous system of white mice in test “open field”, “T-maze”, “Forced swimming”. The results of the study proved the influence of pulsed electromagnetic radiation on cognitive function. Experimental studies were performed in a shielded equipped semi-anechoic chambers with the remote control of the work of the simulator of broadband pulse EMT. At the end of the performed studies it was revealed that when exposed to broadband pulsed electromagnetic radiation into three groups of animals (exposure of 15, 30, 60 minutes) only in the group with exposure for 15 minutes there were no detected changes in behavioral responses. In the other two groups there were shown statistically significant changes in indices of the horizontal and vertical locomotor activity. The results confirm the possibility of separation between the processes of inhibition and excitation under the influence of EMF of low intensity (non-thermal) on biological objects.
MODERN ALTERNATIVE TOXICOLOGICAL RESEARCH METHODS AND PROSPECTS OF THEIR USE IN PRACTICAL ACTIVITIES
Authors: Zaritskaya Ekaterina V. , Polozova E. V. , Bogacheva A. S.
Published: October 2019

Based on literature review and own experience, grounds for necessity of toxicological assessment of goods and ecological state are given. As industry and economical activity develops, new chemicals, materials and goods appear, the problem of environmental protection and human chemical safety is becoming increasingly crucial. According to the legislation of most civilized countries, including Russian Federation, all chemicals, materials, goods, industrial waste and consumption residue which are potentially dangerous for humans must pass toxicological expert examination. Classical toxicological study techniques of chemicals, products and goods containing them, are labor-and time-consuming, expensive and as a rule require a lot of laboratory animals of various species. Moreover, the use of mammals is embarrassing from an ethical point of view. Therefore in late decades a search for new alternative techniques and instruments which could reliably reflect the effect of various toxicants on human body is actively being carried out. Sanitary-toxicological methods are shown to be predominantly used for the quality assessment and regulation of the production and environmental objects, especially in perfumes and cosmetics examination due to the prohibition of testing of cosmetics and its ingredients on animals in European Union countries. General characteristics and availability of the determination of the toxicity with the use of alternative testing techniques, such as computer toxicity simulation (in silico techniques), grouping of similar chemicals into categories, laboratory research (in chemico, ex vivo, in vitro methods) are reported. Characteristics of up-to-date alternative techniques which are most widely used in sanitary-toxicological studies are shown.
METHODUCAL APPROACH AND ASSESSMENT OF NOISE IMPACT OF RAIL TRANSPORT ON THE BASIS OF THE USE OF RISK ASSESSMENT METHODOLOGY
Authors: Kopytenkova Olga I. , Kurepin D. E. , Fridman K. B. , Kuznetsova E. B.
Published: October 2019

The paper presents the results of measurement, prediction and assessment of noise in the territory in the zone of the influence of the railway transport. The railway transport is established to be a source of excess acoustic impact on the environment within the area of sanitary break (100 m). The dependence of the change in noise levels from freight trains at a distance of 100 m from the source and up to 30 m from the ground surface was revealed. Equivalent sound levels in octave bands for the railway section of the model are calculated. Based on the results of field measurements and calculated data, the identification of indices of risk for adverse reactions in the population living in the zone of influence of the Railways was executed. The paper presents results of the calculation of the probability of occurrence of complaints on excessive noise and the likelihood of irritation at the noise, and the results of the calculation of risk indices of pathologies of the nervous and cardiovascular systems. The research made it possible to identify the regulatory documentation discrepancy in the definition of the health gap between the line source traffic noise and residential buildings. Field measurements and executed on their basis their modeling of the noise propagation (without obstacles) have shown that on the boundary of the regulatory sanitary protection zone (100m) in the congested section of the railway the noise level of 60-62 dBA is maintained. The risk of irritation to the noise and the likelihood of complaints is assessed as “acceptable”. The risk of pathology of the cardiovascular system is evaluated as “low”. At a distance of 50 m (65 dBA) with bearing in mind age-related changes after 70 years of exposure the risk reaches of extreme values - 0,935. Construction sites located less than 100 m from the railway were shown to fall into the zone of acoustic discomfort. There was substantiated the necessity of resolving differences in regulatory documentation by harmonizing sanitary and technical groups documents regulating methods of measurement, prediction and evaluation of sound levels on the territories in the zone of influence of the Railways.
RATIO OF PROCESSES OF CELL PROLIFERATION AND APOPTOSIS IN THE SKIN UNDER EXPOSURE TO HEAVY METAL SALTS AND CHELATORS OF ESSENTIAL METALS
Authors: Nikolaeva Tatyana V. , Polyakova V. S. , Setko N. P. , Voronina L. G.
Published: October 2019

In the model experiment on C57BL /6 mice there were established features of the impact of heavy metals and chelators of essential metals on proliferation and apoptosis of epithelial skin cells (keratinocytes). For the execution of a study 40 test animals were divided into seven experimental and 1 control groups, each consisted of five animals. The proliferative and apoptotic activity of keratinocytes was determined by the immunohistochemical method and evaluated by calculating the proliferation index and the index of apoptosis in the cells of the surface epithelium and the epithelial cells of hair follicles in the late anagen stage. Comparative analysis of the proliferation index of the control group and experimental groups showed administration of zinc sulfate, sodium dichromate and zinc chelator (N, N, N`, N`-tetrakis (2-pyridylmethyl) ethylenediamine) to animals to give rise in a statistically significant increase in the proliferative activity of keratinocytes. The decline of proliferation index was detected in animals treated with lead acetate and copper chelator (ammonium tetrathiomolybdate). Introduction of an iron chelator (deferoxamine) had no effect on the proliferative activity of keratinocytes in experimental animals. Induction of apoptosis of epithelial cell was noted under the administration of nickel sulfate, sodium dichromate, lead acetate and zinc chelator (N, N, N`, N`-tetrakis (2-pyridylmethyl) ethylenediamine) to animals. In mice received deferoxamine zinc sulfate and apoptotic activity of keratinocytes has not changed. The use of cluster analysis allowed to classify substances administered to experimental animals, taking into account their simultaneous effect on the studied cellular processes. Lead acetate, iron chelator (deferoxamine) and copper chelator (ammonium tetrathiomolybdate) were shown to reduce the proliferative activity of keratinocytes and have little effect on apoptosis of the epithelial cells of the skin. Zinc sulfate, nickel sulfate, sodium dichromate and zinc chelator (N, N, N`, N`-tetrakis (2-pyridylmethyl) ethylenediamine) activate cell proliferation and induce apoptosis of keratinocytes.
HYGIENIC EVALUATION OF THE CLASS HAZARD OF DISCHARGES FROM ROAD-VEHICLES COMPLEX
Authors: Alikbayeva Lilya A. , Kolodiy S. P. , Bek A. V.
Published: October 2019

The purpose of the study. Hygienic evaluation of discharges from the road-vehicle complex to justify recommendations for handling it in urbanized areas. Material and methods. The object of the study was discharges from the road-vehicles complex (RVC) in four cities of Russia - Saint-Petersburg, Chelyabinsk, Perm and Ufa. The research program included the analysis of the chemical composition of RVC discharges; determination of hazard classes of waste for the health of the person at the SP 2.1.7.1386-03 “Sanitary rules on determining the hazard class of toxic production wastes and consumption” (2003) and the calculation of class of danger according to the degree of negative impact on the environment in accordance with the “Criteria for classification of wastes of hazard classes I-V according to the degree of negative impact on the environment” (2014). Results. In the analyzed samples silicon dioxide (up to 92%) appeared to be the main component of RVC discharges in cities of Petersburg, Perm, Chelyabinsk and Ufa. In RVC discharges the content of seven chemical substances hazard class 1 and 2 exceeded their MPC in soil: copper - by 10 to 35 times, Nickel - from 2.6 to 61.7 times, zinc - from 3 to 5.5 times, arsenic - from 2 to 4.4 times, chromium - 2.1 to 36.6 times, cobalt - from 1.3 to 2.8 times, benzo(a)pyrene from 1 to 4.4 times. According to class of danger to human health RVC discharges waste in four cities refer to hazard class 2- highly hazardous waste, and on the basis of indices, the total index of hazard waste for the environment to hazard class 4 - low hazard waste. Mandatory collection and removal from RVC from urban areas is recommended. It is necessary to perform additional studies to assess of migration-water hazard index RVC discharges with the aim of the determination of regulations for its disposal and storage outside the city.
METHOD OF ACOUSTIC QUALIMETRY OF MEANS OF COLLECTIVE PROTECTION FROM NOISE
Authors: Bogomolov A. V. , Dragan Sergey P.
Published: October 2019

Results of hygienic investigations indicate to the inefficiency of the operating collective protection from noise, resulting in the decreased reliability and increased morbidity rate of the personnel. Known methods of quality control means of protection against noise are not applicable for acoustic qualimetry of means of the collective protection, as it fails to take into account a number of informative speaker security features. The study was executed in 2012-2015, in the framework of health monitoring working conditions of staff of the three airports, exposed to the cumulative effect of noise. During the period of the study there were investigated the hygienic conditions in the workplace 134 workers, working conditions, which in terms of the acoustic environment in workplaces classified as harmful. The developed method of acoustic qualimetry of the collective protection from noise involves the synthesis of the integral index (ratio of acoustic efficiency), which is a convolution of the primary indices determining the change of hearing thresholds of staff before and after the work shift on the octave frequencies of 125 Hz, 250 Hz, 500 Hz, 1000 Hz, 2000 Hz, 4000 Hz and 8000 Hz, and the maximum values (recorded during the work shift) of the sound pressure levels inside the means of collective protection for the octave frequency 31.5 Hz, 63 Hz, 125 Hz, 250 Hz, 500 Hz, 1000 Hz, 2000 Hz, 4000 Hz, 8000 Hz. Application of this method is very valuable for the health monitoring of working conditions and the certification of work of staff of places, because it allows not only assess risks of occupational and work-related diseases and to reduce the professional reliability, but also reveal the presence of the structural deficiencies of collective protection affecting the acoustic safety of personnel, it is essential to select, test means of collective protection, as well as to justify proposals for their improvement.
DETECTION OF PATHWAYS OF TRITIUM ENTRY INTO FRESHWATER ORGANISMS IN THE EXPLOITATION OF THE MINING AND CHEMICAL COMBINE
Authors: Lashchenova T. N. , Bondareva Lydia G. , Fedorova N. E. , Rakitsky V. N.
Published: October 2019

The global pollution of the environment and the functioning of the Mining and Chemical Combine (MCC), Rosatom State Corporation are potential sources of tritium in the Yenisei River ecosystem. The distribution of residual tritium in organs and tissues of the freshwater rayfinned fish Carassius gibelio (Prussian carp) as a representative of the Carassius phytophagous genus of Cyprinidae family was studied for the determination of the 3Н accumulation in the aquatic plants-fishes food chain in water bodies contaminated with radionuclides. At the first stage, the work was done on the accumulation of tritium by the biomass of hydrobiont plants. To do this, 3000 g of biomass in terms of wet weight were placed in aquaria with a volume of 100 liters with specific water activity of 100 kBq/l. The work shows mentioned aquatic plants to accumulate actively the introduced tritium, storing up to 70% of the radionuclide. At the same time, the content of organically bound tritium in biomass increased to 21% of total accumulated tritium. Then the plants (hornwort, duckweed) were dried, mixed with dry fish food (1: 1), and the mixture was compressed into pellets, each with activity up to 50 Bq. The pellets were used for forcible feeding of fish, during the experiment, each individual absorbed up to 330 kBq of tritium radionuclide for 550 days. Studies have shown about 75% of the total accumulated amount of tritium in fish specimens to present in muscle tissue. When determining the content of tritium in proteins and lipids in experimental systems, no specific features have been revealed in the use of Ceratophyllum and Lemna as a source of nutrition.
RADIATION HYGIENIC ASPECTS OF THE SAFETY CONTROL OF THE PERSONNEL
Authors: Simakov Anatoly V. , Abramov Yu. V. , Proskuryakova N. L.
Published: October 2019

Control of the radiation safety of workers is the one of the principal tasks of regulatory bodies responsible for the radiation safety and protection. This task is solved through the implementation of a set of organizational and technical measures, including:1) Organization and the execution of radiation monitoring; 2) Prediction of exposure doses to workers; 3) Selection of workers for the execution of radiation hazardous operations including emergency remedial works; 4) Planning of activities to implement the principle of the optimization of radiation protection; 6) Development and establishment of reference levels of exposure to radiation factors; 5) Organization of education and training of the personnel; 7) Continuous improvement of the occupational safety culture etc. The paper describes main actions of the management of radiation facilities aimed at the implementation of the above mentioned measures. Special attention is paid to the selection of the personnel of the required qualifications, possessing a sufficient reserve of an individual dose, to carry out radiation hazardous operations, to predict radiation doses to justify the development of the necessary protective measures and to plan actions to implement the principle of optimization of the radiation protection. The active use of the computer information and analytical system for the management of the protection from the occupational radiation is recommended. This system should include: 1. Database of individual occupational doses; 2. Database of radiation parameters characterizing the situation in workshops and at the industrial site of the radiation facility; 3. Software package for education and training of the personnel. The making of managerial decisions for the radiation protection of the personnel is aimed at increasing in the occupational reliability and, ultimately, improving the safety of radiation facilities, maintaining health and increasing the professional longevity of workers.
CYTOTOXIC ACTIVITIES PROFILE OF PARASITE MANGO (Dendrophthoe pentandra) FROM VARIOUS AREAS IN INDONESIA AGAINST T47D BREAST CANCER CELLS AND NORMAL VERO CELL LINES
Authors: Mutiah Roihatul
Published: October 2019

Indonesia has so many kinds of a parasite (mistletoe), one of them which has potential anticancer activity is mango parasite (Dendrophthoe pentandra). This research aimed at determining the cytotoxic activity profile of mango parasite leaves extracts from several locations in Indonesia against T47D and Vero cell lines. Mango parasite leaves obtained from 4 locations in Indonesia: Kediri, Pekalongan, Sumatra, and Kalimantan. Three samples was obtained from 3 different sub-districts in each locations. Cytotoxic activities of samples were performed by MTT assay method. The results of this study showed that there were differences between samples obtained from different locations, especially in cytotoxic activity and selectivity indexes of mango parasite leaves (D. pentandra) ethanol extract. D. pentandra obtained from Kalimantan has the most potential cytotoxic activity and could be potentially developed into a T47D breast anticancer agent. Extracts from the Kalimantan have an IC50 values of287.39 μg/ml, LC50 798.28 μg / ml and selectivity index 2.77, which means it was toxic to cancer cells but safe for Vero cell lines, and its selectively kills cancer cells rather than Vero cell lines. The result of this study could support D. pentandra to be developed as a new potential Fitofarmaka.
FORMULATION AND CHARACTERIZATION OF SUNSCREEN MICROEMULSION OF PINEAPPLE EXTRACT (Ananas comosus (L.)) WITH SYNERGISTIC EFFICACY ON SUN PROTECTION FACTOR (SPF)
Authors: Mutiah Roihatul , Sukma Yolanda Cahyaning , Megawati Dewi Sinta , Annisa Rahmi
Published: October 2019

The root of Calotropis gigantea (thistle) is an Indonesian herb to treat cancer based on empirical and scientific evidences. The study aims to find out the infuence of ethanol extract of Calotropis gigantea root in inhibiting cancer cell growth of Mus musculus fibrosarcoma in vivo and to find out metabolite compound in the Calotropis gigantea root extract. The effect of cancer cell growth inhibition was tested on Mus musculus inducted with 7.12-dimetilbenz (α) antrasena (DMBA) and dose treatment of 50, 100 and 150 mg/Kg body weight. The metabolomic analysis on the root employs UPLC-QToF-MS/MS as a positive ESI ion source, the movement phase of water/acid mixture is 99.9/0.1 [v/v] and acetonitrile/formic acid was 99.9/0.1 [v/v] with gradient elution system and stationary phase of C18. The chromatogram was analyzed using Masslynx 4.1. The component identification was based on the m/z ratio measured in Masslynx and m/z counted in chemdraw. The result of the study showed that the Calotropis gigantea root extract with the dose of 50, 100 dan 150 mg/Kg body weight were able to increase the weight of fibrosarcoma mice and have a significant influence on caspase-3 expression with cell apoptosis index 24.3 %; 13.3 % and 12.3 % respectively. The result of metabolomic analysis showed 14 compounds found in the root extract. There are two major compounds: 4-Chlorobenzenethiol with the area 32.51% and N-[1-(Adamantan-1-yl) ethyl]-2-(1-piperidinyl)-4-quinazolinamine with the area 37.20%. They are indicated responsible for the anticancer activity of Calotropis gigantea root extract.

 Keywords: Calotropis gigantea, caspase-3, fibrosarcoma, metabolomic, UPLC-QToF-MS/MS
Transcultural Validation of the 12-Item Scale of Economic Abuse in Chinese Population
Authors: Yau Jessie Ho-Yin , Wong Janet Yuen-Ha , Choi Edmond Pui-Hang , Fong Daniel Yee-Tak
Published: October 2019

The aim of this study was to report translation and transcultural adaptation of the Chinese version of the 12-item scale of economic abuse (C-SEA-12) and evaluate its psychometric properties. Forward translation, backward translation followed by consensus meeting with expert committees were done to create the Chinese version. Then, the translated C-SEA-12 was validated on 399 Chinese adults from a territory-wide household survey in Hong Kong. A second-order factor model of C-SEA-12 was demonstrated with adequate goodness of fit (root mean square error of approximation [RMSEA] = .05, comparative fit index [CFI] = .99, Tucker–Lewis Index [TLI] = .98, SRMR = .03) through exploratory and confirmatory factor analysis. The reliability (Cronbach's α coefficient = .92) and validity were satisfactory. The C-SEA-12 was demonstrated to be a reliable and valid measurement to assess economic abuse in Chinese population.
Crítica al uso de la memoria como recurso de aprendizaje durante el siglo XIX en Chile
Authors: Lara Jesús Moisés
Published: October 2019

El presente artículo tiene como propósito dilucidar de qué manera, durante gran parte del siglo XIX, en Chile, se comenzó a discutir el tipo de enseñanza que se empleaba en la educación, principalmente la que estaba orientada a desarrollar la transferencia de información de forma mecánica, teniendo como único propósito el desarrollo de la memoria para repetir conceptos y frases. Por esta razón, se realizó un revisionismo historiográfico de fuentes primarias de aquella época, para, por medio de ellas, analizar cuáles eran las posturas y las críticas que se hacían a las estrategias educativas clericales, pero también cuáles eran las orientaciones pedagógicas que se debían comenzar a adoptar para generar cambios en la educación. En consecuencia, el aporte de este estudio consiste en demostrar que la voluntad de reestructurar la enseñanza-aprendizaje, centrada en el desarrollo de habilidades de orden superior en los estudiantes, tiene antecedentes continuos a lo largo de todo el siglo XIX.
AS ANDANÇAS E OS DESAFIOS À AMBIENTALIZAÇÃO CURRICULAR
Authors: Marcomin Ivana , Plá Gilmar Pezzopane , Marcomin Fatima Elizabeti
Published: October 2019

O texto é um recorte da pesquisa realizada em uma universidade do estado de Santa Catarina sobre ambientalização curricular. Indícios de ambientalização da Rede ACES e estudos de universidades latino-americanas e brasileiras, com emprego do software MAXQDA nos Projetos Político Pedagógicos dos cursos e Planos de Ensino de disciplinas sustentam a pesquisa. O objetivo foi discutir como ocorre essa inserção à luz de uma formação crítica, transformadora e emancipatória. Alguns dos resultados apontam para a dificuldade de inserção da temática ambiental, da sustentabilidade e da Educação Ambiental nos cursos e nas disciplinas. Os indícios, quando ocorrem, em sua maioria reportam-se aos conteúdos e, em menor proporção, às habilidades e competências. Há necessidade de intensificação dos esforços para inserção da temática em uma vertente crítica, transformadora e emancipatória.
O PROFESSOR UNIVERSITÁRIO E A SALA DE AULA DO ENSINO SUPERIOR
Authors: Santos Samuel Carvalho , Cária Neide Pena
Published: October 2019

Este artigo investiga as relações entre a experiência, a teoria e a prática, compondo a chamada competência pedagógica na sala de aula universitária. O objetivo é contribuir com a discussão em torno da relação entre ensino e aprendizagem, priorizando a relação entre o pedagógico e o epistemológico, tendo em mente a hipótese de que toda prática em sala de aula é amparada epistemologicamente em uma determinada concepção, crença e valores. O aspecto fulcral do Ensino Superior está ligado ao ensino de adultos e, portanto, as relações de ensino e aprendizagem neste nível de ensino diferem de uma pedagogia voltada para a criança e o adolescente. A competência acadêmica é um processo a ser construído no dia a dia, continuamente, enfrentando o desafio de superar o modelo tradicional de ensino.
Jurisdiction and applicable law to contracts for the sale of goods and the provision of services including the carriage of goods by sea and other means of transport in the European Union = Jurisdicción y derecho aplicable a los contratos de compraventa de mercaderías y de prestación de servicios incluyendo el transporte de mercancías por vía marítima y otros medios de transporte en la Unión Europea
Authors: Echebarría Fernández Jonatan
Published: October 2019

Abstract: The article analyses the jurisdiction and applicable law to contracts for the sale of godos and the provision of services in the European Union. It particularly focuses on contracts that subsume different categories of contracts, such as the carriage of goods by sea, in a contract for the sale of godos and the provision of services. The European Union law and the interpretation provided by the Court of Justice of the European Union shed light into the place of performance of the contract in order to set jurisdiction for national courts. This is explained through the current legal framework and the case law in order to ascertain where and under what legal regime the claimant may start proceedings for the breach of a contractual obligation or in case of a non-contractual claim.Keywords: provision of services, sale of goods, carriage of goods by sea and other means of transport, Court of Justice of the European Union, contractual actions, place of performance of the contractual obligation, non-contractual actions, applicable law, game theory, contractual efficiency.Resumen: El artículo analiza la jurisdicción y la ley aplicable a los contratos para la venta de bienes y la prestación de servicios en la Unión Europea. En particular, se centra en los contratos que subsumen diferentes categorías de contratos, tales como el transporte de mercancías por mar, en un contrato de venta de mercaderías o de prestación de servicios. El Derecho de la Unión Europea y la interpretación dada por el Tribunal de Justicia de la Unión Europea arrojan luz sobre el lugar de cumplimiento del contrato con el fin de establecer el tribunal nacional competente. Esto se explica a través del marco legal actual y casos para determinar dónde y bajo qué régimen legal el demandante puede interponer una demanda por incumplimiento de una obligación contractual o en caso de una reclamación extracontractual.Palabras clave: prestación de servicios, compraventa de mercaderías, transporte de mercancías por vía marítima y otros medios de transporte, Tribunal de Justicia de la Unión Europea, acciones contractuales, lugar de ejecución de la obligación contractual, acciones extracontractuales, derecho aplicable, teoría de juegos, eficiencia contractual.
La inseguridad jurídica derivada de la insuficiente regulación de la gestación subrogada en España = Legal insecurity arising from the insufficient regulation of surrogacy in Spain
Authors: Vilar González Silvia
Published: October 2019

Resumen: La regulación legal española de la gestación subrogada, por la que cualquier acuerdo que la tenga por objeto será declarado nulo de pleno derecho, no evita que las familias españolas recurran a ella en países extranjeros donde su práctica es legal, para hacer realidad su voluntad procreativa. Los mecanismos legales que, de forma parcial y cambiante, se han ido implementando en nuestro país para, en determinadas circunstancias, permitir la inscripción del nacimiento y filiación de los niños nacidos en el extranjero a favor de sus padres intencionales, suponen una grave inseguridad jurídica y una clara incongruencia de nuestro marco legislativo. Por ello, resulta extremadamente necesario crear las instituciones adecuadas que otorguen respuesta a las nuevas necesidades planteadas y protejan los intereses personales en juego.Palabras clave: gestación por sustitución, filiación, interés superior del menor, autonomía de la voluntad, inseguridad jurídica.Abstract: The current legal situation on surrogacy in Spain, prescribing that any agreement aimed at such process shall be declared null and void, does not prevent Spanish families from going abroad to fulfil their procreation will through this technique. The partial and changing legal mechanisms that have been implemented in our country to allow, in certain circumstances, the birth registration as well as the filiation of the child born abroad through surrogacy in favour of the intended parents, leads to a serious legal uncertainty and to a clear incongruence of our legislative framework. Thus, it is extremely necessary to create the appropriate institutions that may give response to the new stated needs and protect the personal interests affected.Keywords: surrogacy, filiation, best interests of the child, autonomy of the will, legal uncertainty.
Violencia por razón de género en la pareja y estereotipos en el sistema de justicia: lecciones del Comité de la CEDAW = Gender-Based Violence in Intimate Relationships and Stereotypes in the Justice System: Lessons from the CEDAW Committee
Authors: Cardoso Onofre de Alencar Emanuela
Published: October 2019

Resumen. El presente trabajo estudia la estereotipia de género en el sistema de justicia en casos de violencia contra las mujeres por razón de género en la pareja. En primer lugar, investiga qué son los estereotipos de género, cuáles son sus principales efectos e identifica algunos de los estereotipos más frecuentes en casos de violencia en la pareja. Luego analiza la contribución del Comité de la CEDAW a ese tema. El Comité ha sido pionero en señalar los vín­culos entre el uso de estereotipos, la discriminación y la violencia de género y, en los últimos años, ha demostrado cómo la estereotipia de género en el sistema de justicia, especialmente en casos de violencia en la pareja, vulnera derechos humanos y discrimina. Su trabajo ofrece estándares internacionales para combatir ese tipo de violencia y para guiar el desarrollo ju­rídico de esa materia, y proporciona argumentos para poner de manifiesto que la estereotipia obstaculiza el acceso de las mujeres a la justicia en igualdad de condiciones.Palabras clave: violencia de género, violencia en la pareja, discriminación, sistema de justicia, Comité de la CEDAW.Abstract. This paper studies gender stereotyping in the justice system in cases of inti­mate violence. First, it examines what are stereotypes, what are their main effects and points out some of the most frequent stereotypes in cases of intimate violence. Then it analyses the contribution of the CEDAW Committee on this subject. The Committee has a ground-breaking work in the linkages between stereotyping, discrimination and gender-based violence, and in the last years has underlined how gender stereotyping in the justice system, especially in cases of intimate violence, undermines human rights and discriminate. Its work offers international standards to address this kind of violence, leads legal development on this subject, and gives arguments to take seriously stereotyping in the justice system.Keywords: gender violence, intimate violence, discrimination, justice system, CEDAW Committee.
Mujer, trabajadora y madre: la superheroína del siglo XXI = Woman, Worker and Mother: the Superheroine of the 21st Century
Authors: Rodríguez Navarrete Laura
Published: October 2019

Resumen. La inserción de la mujer en el mercado laboral es un claro ejemplo de logro histórico ya que, gracias a la lucha de muchas mujeres, a día de hoy, es una realidad que la población femenina ha logrado su inserción en el mercado laboral. Sin embargo, aun queda mucho camino por recorrer, prueba de ello es que, en la actualidad aún existe un cierto rechazo a considerar que la mujer está cualificada para ser trabajadora, dando lugar a la segregación ocupacional y vertical que provoca como resultado la brecha salarial, circunstancia que refleja como sufre una discriminación salarial frente a los trabajadores de sexo masculino, simple­mente por su género. El objetivo perseguido con este ensayo consiste en facilitar al lector una visión genérica de cómo la situación de la mujer en el mercado laboral se ha ido transforman­do hasta llegar a la visión actual, finalizando con una reflexión que pretende constatar en los lectores la importancia de favorecer una igualdad plena y real en la sociedad.Palabras claves: mujer, trabajadora, igualdad, discriminación, segregación ocupacional, brecha salarial,Abstract. The insertion of women in the labor market is a clear example of historical achievement because, thanks to the struggle of many women, today, it is a reality that the female population has achieved its insertion in the labor market. However, there is still a long way to go, because, at present, there is still occupational segregation which drives to the wage gap and, even, wage discrimination. The objective pursued with this essay is to facilitate the reader a broad view of how the situation of the women in the labor market has been trans­forming until achieving the current situation.Keywords: women, workers, equality, discrimination, occupational segregation, wage gap.
Desafios Diagnósticos e Terapêuticos na Síndrome Hemolítica Urémica Atípica: A Propósito de Um Caso Clínico
Authors: Reis Sofia , Ramos Daniela , Cordinhã Carolina , Gomes Clara
Published: October 2019

A síndrome hemolítica urémica atípica constitui uma microangiopatia trombótica resultante da hiperativação da via alterna do complemento. A sua gravidade exige diagnóstico e terapêutica precoces. O diagnóstico diferencial inclui a síndrome hemolítica urémica típica (associada à toxina Shiga) e a púrpura trombótica trombocitopénica (associada a deficiência na atividade da ADAMTS13). A terapêutica específica da síndrome hemolítica urémica atípica, atualmente disponível, é o eculizumab. Descrevemos um caso clínico de uma criança com síndrome hemolítica urémica atípica diagnosticada em contexto de diarreia sanguinolenta, complicada de envolvimento neurológico e que colocou vários desafios no diagnóstico e decisões terapêuticas.
Morphological Indexes: Can They Predict Lupus Nephritis Outcomes? A Retrospective Study
Authors: Navarro David , Ferreira Ana Carina , Viana Helena , Carvalho Fernanda , Nolasco Fernando
Published: October 2019

Introduction: Lupus nephritis is a serious complication of systemic lupus erythematosus. Currently, therapy is guided by findings in the renal biopsy, following the International Society of Nephrology / Renal Pathology Society classification. Austin and Hill’s histomorphological indexes are not routinely obtained. In this retrospective single-centre study, we aimed to analyze the importance and applicability of the different morphological indexes in predicting response to treatment and prognosis.Material and Methods: Patients with kidney biopsy demonstrating lupus nephritis from the 2010 – 2016 period were included. We analyzed their demographic data, comorbidities, clinical presentation and laboratorial evaluation at the time of renal biopsy. We evaluated the following outcomes: clinical remission, renal function and proteinuria at end of follow-up. Histologic analysis was performed using the International Society of Nephrology / Renal Pathology Society classification and the morphological indexes described by Austin (Activity and Chronicity) and Hill. Univariate and multivariate statistical analysis was performed using STATA software.Results: We analyzed 46 biopsy-proven lupus nephritis cases, with a median follow-up of 31.9 (13.2 – 45.6) months. Based on biopsy findings, 35 patients were started on immunosuppressive therapy. We observed that Class IV patients had, at presentation, lower estimated glomerular filtration rate (67.3 vs 94.6 mL/min; p = 0.02), higher proteinuria (4.26 vs 2.37 g/24 hours; p = 0.02) and a non-significantly higher C3 consumption (58.9 vs 77.4 mg/dL; p = 0.06). We did not observe correlations between International Society of Nephrology / Renal Pathology Society classification and the outcomes at the end of follow-up. In contrast, both the Hill biopsy index and Austin’s Chronicity index were correlated with renal function and proteinuria at the end of follow-up. Austin’s Activity index correlated with the immunological findings (C3, C4 and anti-dsDNA) at presentation.Discussion: Because clinical activity poorly correlates with histologic activity, histological findings are fundamental when assessing patients with suspected lupus nephritis. The most recent International Society of Nephrology / Renal Pathology Society report supports the European League Against Rheumatism guidelines, encouraging the adoption of histomorphological indexes when evaluating lupus nephritis. Our data, showing a correlation between the renal outcomes and the indexes described by Austin and Hill, supports this view.Conclusion: The histomorphological indexes in lupus nephritis are easily obtainable, can predict renal outcomes and may help in the management of such patients.
How Prepared are We to Address Sexuality in Palliative Care?
Authors: Silva Sofia Macedo , Marques José , Reis-Pina Paulo
Published: October 2019

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Clinical Decision Support Improves Decision-Making and Leads to Better Outcomes
Authors: Bonis Peter A.
Published: October 2019

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Mania Induzida por Mirtazapina: Um Caso Clínico
Authors: Freitas Catarina , Barranha Rui , Abreu Tânia , Von Doellinger Orlando
Published: October 2019

O desenvolvimento de estados maníacos e hipomaníacos associado ao uso de antidepressivos é relativamente comum. Contudo, no caso da mirtazapina, este é um efeito secundário raro. Os autores descrevem um caso clínico de um episódio maníaco de características disfóricas, num doente sem antecedentes psiquiátricos pessoais ou familiares, com instalação duas semanas após início de tratamento com mirtazapina até 30 mg/dia. Uma vez suspensa a mirtazapina e iniciada olanzapina (10 mg) verificou-se remissão sintomática. A mirtazapina apresenta uma farmacodinâmica particular, sendo antagonista não só de recetores serotoninérgicos póssinápticos, mas também de recetores adrenérgicos pré-sinápticos α2. Neste sentido, colocou-se a hipótese de se tratar de uma síndrome noradrenérgica, caracterizada por disforia, irritabilidade, insónia e agitação psicomotora.
Indiferença
Authors: Lopes João Gabriel Mostazo
Published: October 2019

O artigo procura demonstrar como a antipoesia de Nicanor Parra (Chile, 1914--2018) articula uma relação negativa com o paradigma da poesia lírica. Sugerimos que essa relação é caracterizada como “indiferença”. Para isso, nos detemos sobre a questão do humor na poesia de Parra, tendo como referência as teorias sobre comédia da filósofa eslovena Alenka Zupančič (2008). O caso específico da relação entre humor e religião, na antipoesia, é examinado através do prisma da ideia de profanação. O arco da reflexão se estabelece a partir da hipótese de que o paradigma da antipoesia seria o de uma “incompletude ontológica imanente”, oposto à totalização transcendente da poesia lírica, traço aquele compartilhado com uma estrutura cômica do discurso.
"Harmonias do inferno"
Authors: Veras Eduardo
Published: October 2019

Este artigo propõe uma análise da relação problemática que a poesia de Baudelaire estabelece com a música. Pretendemos mostrar como o poeta dramatiza a desestruturação da linguagem poética tradicional pela adesão a uma retórica da desarmonia, da dissonância e do baraulho, sem contudo se render à completa falência do poético. Nesse sendito, a presença do barulho no seio de uma poética nostálgica da harmonia se dá como elemento de tensão oximórica muito mais que como saída definitiva do universo da poesia, regida, até o início do século XX, pelo paradigma musical do lirismo.