bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation of anticoagulation in atrial fibrillation patients with rivaroxaban—from trial to target population
Authors: Zhang Chi , Wang Wei-Wei , Pan Mang-Mang , Gu Zhi-Chun
Published: September 2021

The populations included in the randomized controlled clinical trials and observational studies were different. The effectiveness and safety of rivaroxaban for stroke prevention in patients with atrial fibrillation (AF) varied among studies. This study aimed to estimate the real-world outcomes of rivaroxaban in patients with AF accurately. A discrete event simulation (DES) was used to predict the counterfactual results of the ROCKET AF study. The hypothetical cohorts of patients were generated using Monte Carlo simulation according to the baseline covariate distributions that matched the marginal distribution of covariates reported in the ROCKET AF and three observational studies. The DES model structure was constructed based on a priori knowledge about disease progression and possible outcomes of patients with AF. The DES model accurately replicated the overall results of the ROCKET AF study. Both predicted stroke/systematic embolism (SE) and major bleeding rates were lower in the three observational studies than in the simulated ROCKET AF study. The risk difference of stroke/SE and major bleeding was not significant among the predicted outcomes of the three observational studies. Although some differences existed in the absolute rates of stroke/SE and major bleeding between observed and simulated studies, the results confirmed that rivaroxaban was noninferior to warfarin for the prevention of stroke/systematic embolism with no significance in the risk of major bleeding in large AF populations, which was similar to the results of ROCKET AF.
Endovascular repair of traumatic aortic dissection: a single-center experience
Authors: Wang Yingliang , Li Tongqiang , Liu Jiacheng , Shi Qin , Zhou Chen , Yang Chongtu , Huang Songjiang , Chen Yang , Xiong Bin
Published: September 2021

The data on endovascular aortic repair (EVAR) for traumatic aortic dissection (TAD) are lacking. Hence, this study aimed to evaluate the efficacy of EVAR for TAD and report our experience based on patients from our medical center with a relatively long follow-up. A total of 25 consecutive patients with TAD underwent EVAR from October 2015 to October 2020. The demographics, imaging characteristics, clinical features, treatment details, and follow-up results were reviewed. Urgent EVAR was performed in 3 patients (12%), while the remaining 22 patients (88%) underwent delayed EVAR. Systematic heparinization was used in all patients during the endovascular procedure. The EVAR was technically successful in all patients, with no cases converted into open surgery. No death occurred during the perioperative period. One patient presented with a type II endoleak on postoperative 1-month CT images during a mean follow-up of 42.3 ± 17.7 months (5–67.5 months) and showed spontaneous regression of the endoleak without any intervention during the subsequent follow-up. All the patients survived until the time of writing, and none of them showed late endoleak, stent migration, paraplegia, and reintervention. The patients with left subclavian artery covered (n = 8) had no obvious ischemia of the arm and brain. The study results demonstrated that EVAR for TAD proved to be safe and effective, and most patients could undergo delayed EVAR. Systematically heparinization during EVAR under the setting of multi-trauma was safe.
Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy
Authors: Kim Gun Jik , Jung Hanna , Lee Eunjo , Chung Sung Woon
Published: September 2021

Histone deacetylase (HDAC) inhibitors have shown cardioprotective or renoprotective effects in various animal models. Our study proposed that the HDAC inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system (RAS) activity in rats with transverse aortic constriction (TAC)-induced pressure overload cardiac hypertrophy. Cardiac remodelling was evaluated using echocardiography. Cardiac hypertrophy was visualized with haematoxylin and eosin staining, and related gene (Nppa and Nppb) expression was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). Cardiac and renal fibrosis were visualized with picrosirius red and trichrome staining, respectively. Fibrosis related gene (Collagen-1, Collagen-3, Ctgf, and Fibronectin) expression was determined by qRT-PCR. Serum concentrations of RAS components (renin, angiotensin II, and aldosterone) were quantified by enzyme-linked immunosorbent assay and related gene (Renin and Agtr1) expression was determined by qRT-PCR. TAC-induced pressure overload cardiac hypertrophy, which mimics hypertensive heart disease, increased cardiac remodelling, cardiac hypertrophy, and fibrosis in our rat models. Upon treatment with mocetinostat, there was a significant regression in cardiac remodelling, cardiac hypertrophy, and fibrosis in TAC rats. Additionally, pressure overload-induced renal fibrosis and activity of RAS-related components were increased in TAC rats, and were decreased on treatment with mocetinostat. The present study indicates that mocetinostat, an HDAC inhibitor, has cardiorenal protective effects in rats with TAC-induced pressure overload cardiac hypertrophy and offers a promising therapeutic agent for hypertension-related diseases.
Influence of excess weight and obesity on performance and outcome of pulmonary vein isolation with the cryoballoon
Authors: Blockhaus Christian , Waibler Hans-Peter , Gülker Jan-Erik , Bufe Alexander , Seyfarth Melchior , Koektuerk Buelent , Shin Dong-In
Published: September 2021

Pulmonary vein isolation (PVI) has become a cornerstone therapy in the treatment of atrial fibrillation (AF). Patients with overweight or obesity suffer more often from AF, and studies investigating the safety and feasibility of PVI in these patients have shown varying results. In this study we analyzed PVI performed with the 2nd generation cryoballoon (CB) with regard to safety, procedure and fluoroscopy time in patients with normal weight, overweight and obesity. We analyzed 228 consecutive patients treated with CB PVI in our hospital in 2018 and 2019. Fifty nine (25.88%) patients presented with normal weight (body mass index (BMI) of <math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="w1" alttext=" < 25), 115 (50.44%) patients with overweight (BMI between 25 and 29.9) and 54 (23.68%) were obese patients (BMI " display="inline"> > 30). All pulmonary veins (PV) were isolated successfully. Concerning procedural parameters, neither complications, procedural time, nor fluoroscopy time differed significantly. There was a significant increase of dose area product (DAP) in obese patients compared to normal weight and overweight patients (2035.5 ± 1930.1 μ Gym 2 vs. 975.3 ± 814.9 vs. 1325.1 ± 2081.3, p = 0.001) but no significant difference between overweight and normal weight patients (p = 0.611). Our follow-up data of 168 patients (73.68%) observed for 12 months showed no differences in the recurrence of AF in the three BMI groups [80.9% vs. 83.3% (p = 0.733) vs. 86.55% (p = 0.460)]. In conclusion, CB PVI in overweight and obese patients is safe with similar levels of complications and recurrence of AF as patients of normal weight. However, obese patients and operators are exposed to higher radiation doses.
Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients
Authors: MILLION Matthieu , LAGIER Jean-Christophe , TISSOT-DUPONT Hervé , RAVAUX Isabelle , DHIVER Catherine , TOMEI Christelle , CASSIR Nadim , DELORME Léa , CORTAREDONA Sébastien , AMRANE Sophie , AUBRY Camille , BENDAMARDJI Karim , BERENGER Cyril , DOUDIER Barbara , EDOUARD Sophie , HOCQUART Marie , MAILHE Morgane , PORCHETO Coralie , SENG Piseth , TRIQUET Catherine , GENTILE Stéphanie , JOUVE Elisabeth , GIRAUD-GATINEAU Audrey , CHAUDET Herve , CAMOIN-JAU Laurence , COLSON Philippe , GAUTRET Philippe , FOURNIER Pierre-Edouard , MAILLE Baptiste , DEHARO Jean-Claude , HABERT Paul , GAUBERT Jean-Yves , JACQUIER Alexis , HONORE Stéphane , GUILLON-LORVELLEC Katell , OBADIA Yolande , PAROLA Philippe , BROUQUI Philippe , RAOULT Didier
Published: September 2021

We evaluated the age-specific mortality of unselected adult outpatients infected with SARS-CoV-2 treated early in a dedicated COVID-19 day hospital and we assessed whether the use of hydroxychloroquine (HCQ) + azithromycin (AZ) was associated with improved survival in this cohort. A retrospective monocentric cohort study was conducted in the day hospital of our center from March to December 2020 in adults with PCR-proven infection who were treated as outpatients with a standardized protocol. The primary endpoint was 6-week mortality, and secondary endpoints were transfer to the intensive care unit and hospitalization rate. Among 10,429 patients (median age, 45 [IQR 32–57] years; 5597 [53.7%] women), 16 died (0.15%). The infection fatality rate was 0.06% among the 8315 patients treated with HCQ+AZ. No deaths occurred among the 8414 patients younger than 60 years. Older age and male sex were associated with a higher risk of death, ICU transfer, and hospitalization. Treatment with HCQ+AZ (0.17 [0.06–0.48]) was associated with a lower risk of death, independently of age, sex and epidemic period. Meta-analysis evidenced consistency with 4 previous outpatient studies (32,124 patients—Odds ratio 0.31 [0.20–0.47], I2 = 0%). Early ambulatory treatment of COVID-19 with HCQ+AZ as a standard of care is associated with very low mortality, and HCQ+AZ improve COVID-19 survival compared to other regimens.
Kent - Yapı İlişkisi Bağlamında Araç Bomba Saldırılara Alınabilecek Önlemlerin AHP Yöntemi ile Değerlendirilmesi
Authors: İLERİSOY Zeynep Yeşim , GÖKGÖZ Berru İzel
Published: September 2021

Kent içinde meydana gelen saldırılarda, kentsel dokunun vazgeçilmez unsurları olan yapılar ve yapıların çevreleri ciddi zararlar almışlardır. Hasarın yayılmasını önlemek ve hasar alacak çevrenin en kısa sürede eski haline getirmek için, bomba riskini göz önüne alan tasarımlar gerçekleştirmelidir. Bu çalışmada yapılar üzerinde oluşan hasarın, patlamanın hangi tür özelliklerine bağlı olduğu belirlenmiştir. Daha sonra farklı ülkelerin standartları ve uzman görüşlerini de içeren literatür taraması ışığında özellikle araç bomba saldırılarda kent ve yapı ilişkisi bağlamında alınabilecek önlemler belirlenmiştir. Bu önlemler Çok Kriterli Karar Verme (ÇKKV) metodolojisinden Analitik Hiyerarşi Prosesi (AHP) yönteminden yararlanılarak konunun uzmanları tarafından değerlendirilmiştir. Değerlendirmeler sonucunda kent içindeki bu saldırılarda en önemli kriter Kamu Yollarına Mesafe, en az öneme sahip kriterin ise Diğer Riskli Yapılara Erişim kriteri olduğu sonucuna ulaşılmıştır. Kriter ağırlıkları bulunduktan sonra bu kriterler gözleme dayalı tespit yöntemi ile iki tren istasyonu numunesi üzerinde uygulanmıştır. Sonuç olarak, kent içindeki bombalı saldırılara karşı yapı ve çevresi kapsamında öneriler sunan bu çalışma, bilinçli toplum ve güvenli kentleşmenin temellerinin atılmasına yönelik önem teşkil emektedir.
Kentlerin Türkiyesi: İmkânlar, Sınırlar ve Çatışmalar
Authors: ERİKLİ DOĞAN Rumeysanur
Published: September 2021

Bu kitap ekonomik küreselleşmenin Anadolu kentlerindeki etkisini “kent-bölge” kavramını merkeze alarak incelemektedir. Yazarlar 2017 yılında TÜRKONFED için hazırladıkları “Kent Bölge-Yerel Kalkınmada Yeni Dinamikler: Türkiye’nin Kentlerinden Kentlerin Türkiye’sine” başlıklı çalışmadaki on iki kentten dördüne odaklanarak ve rapora ek olarak küreselleşme ve kent literatürleriyle önemli bağlar kurarak bu kitabı hazırlamışlardır (Keyman, Keyder, Genç ve Köse, 2017). Bu yazıda öncelikle kitabın amacını, genel çerçevesini şekillendiren kavramları ve üzerine inşa olunduğu literatürü analiz edeceğim. Akabinde kitabın teorik çerçevesinin İzmir, Adana-Mersin , Konya ve Van vaka incelemelerindeki sonuçlarını paylaşacağım. Yazarlar sadece İzmir’in bir kent-bölge olduğu diğer kentlerin ise kent-bölge olma potansiyeli barındırdığı belirtilerek tüm kentler için kent-bölge olma yolundaki imkânları ve kısıtları politika önerisi olarak sıralamıştır.
Alternatif Gıda Ağları ve Türkiye’de Yurttaş Temelli Gıda İnisiyatifleri
Authors: KARAKAYA AYALP Emel
Published: September 2021

Bu makale Türkiye’de yaklaşık son on beş yıldır örgütlenmekte olan, alternatif gıda ağları (AGA)’nı tarihsel olarak ele almakta ve Yurttaş Temelli Gıda İnisiyatifleri (YTGİ)’ni Türkiye ölçeğinde tartışmaktadır. Bu amaçla AGA yazını derlenmiş ve YTGİ’nin Türkiye’deki mekânsal örüntüsü ortaya konmuştur. Böylece hem mekânsal dağılım ve yığılmalar hem de ortaya çıkış tarihlerine göre inisiyatiflerin görünümü sunulmuştur. Keşifsel araştırmaya dayalı olarak kullanılan veri kaynakları; sosyal medya taramasına, katılımcı gözlem yöntemine, yapılandırılmamış görüşmelere ve kısa iletişimlere, internet üzerinden ulaşılabilen kaynaklara ve raporlara ve diğer ikincil veri kaynaklarına dayanmaktadır. Araştırma 2016-2020 yılları arasında toplanan verilere dayanarak 80 adet inisiyatifi kapsamına almıştır. Araştırmanın sonuçları göstermiştir ki Türkiye’de YTGİ mekânsal olarak çeşitli yığılmalar biçiminde gelişme göstermiştir. Türkiye’de inisiyatiflerin yer seçimlerine ve niteliklerine bakıldığında bu durum karşılık bulmaktadır. Bunu, inisiyatiflerin kent içerisindeki yer seçimleri de desteklemektedir. Türkiye’de ortaya çıkan inisiyatiflerin neredeyse yarısının İstanbul’da bulunması ve diğer dağılımın da kıyılarda yoğunlaşmış olması çalışmanın ortaya koyduğu sonuçlardandır.
Ischemic Stroke in a Young Adult Female Caused by Takayasu’s Arteritis: A Case Report
Authors: Akbar Muhammad , Bahar Ashari , Goysal Yudy , Karmilayanti  , Basri Muhammad Iqbal
Published: September 2021

Takayasu's arteritis is one of the causes of ischemic stroke at a young age, but the occurrence is still rarely reported in Indonesia. Here we report the case of a 19-year-old Indonesian female who was admitted to the Wahidin Sudirohusodo Hospital with a sudden onset of right-sided hemiplegia. Other features of Takayasu’s arteritis were observed, including a discrepancy of more than 10 mmHg between the left and right arm systolic blood pressure, claudication of the extremities, and decreased brachial artery pulse. Left hemisphere cerebral infarction was confirmed on the computed tomography (CT) scan. Angiogram abnormalities were also present, showing occlusion of the left proximal inner carotid artery after branching at the aortic arch, and occlusion of the left subclavian artery. Although no fever was observed on presentation, the patient had an elevated erythrocyte sedimentation rate (ESR) of 44 mm/hour. In conclusion, Takayasu’s arteritis should be considered as a potential cause of ischemic stroke in young adults.
Profitability and Risk Analysis of Catfish Farming Breeding Business in Sleman District, Sleman Regency, Yogyakarta
Authors: Nurrohim Hasa , Subagio Hani , Satoto Shinta Heru
Published: September 2021

This study aims to analyze the profitability and risk of the catfish breeding business in the catfish farmer group in Sleman district, Sleman district, Yogyakarta. Respondents were selected using the census method because the number of population members was less than 30 people. The results of the profitability analysis using the Expense Structure Ratio (ESR), show that the ESR is 0.041, which means that the fixed costs used in production are 4.1% of the total cost. Benefit Cost Ratio (BCR) of 1.304 which shows that every 1 Rupiah in catfish farming investment will generate a profit of 30.4%. The results of the Gross Margin Ratio of 0.265 indicate that the breeding cultivation business provides a gross margin of 26.5% of the remaining income after paying direct costs related to production. From the results of the risk analysis, it was found that the income risk opportunities faced were 14.4% in each harvest season, the magnitude of the risk opportunities due to the increase in feed prices was 5.55%, and the risk of loss due to production fluctuations was 0.28. This study recommends that catfish farming farmers need to ensure the expenditure of production costs and strive to overcome risks both from internal and external factors.
Forgiveness and Perceived Social Support in Teenagers
Authors: Bayın Ümit , Kaya Mehmet
Published: September 2021

In this research, the aim is to investigate the relationship between forgiveness and perceived social support in teenagers in terms of various variables (gender, high school type, education level of parents, expressed relative communication and expressed family, friends, teacher support). The population of the research consists of high school students studying in Kocaeli province in 2019-2020 education year and the research sample consists of 422 students who are chosen with appropriate sampling method from four different high school types in Kocaeli. The data was gathered with “Personal Information Form”, “Forgiveness Scale for Teenagers” and “Perceived Social Support Scale”. Also, in order to analyse the data, pearson product-moment correlation coefficient technique, regression analysis, one-way analysis of variance, T-test were used (p<.05). According to the findings obtained from the research, it was found that there is a significant relation in a positive way between teenagers’ forgiveness tendency and perceived social support points. In addition, it was determined that there is a significant and positive relation between perceived social support and empathy establishment aspect of forgiveness and again, between perceived social support and forgiveness tendency. The obtained findings were discussed and interpreted by dealing with the research’s hypothesis frame and the related researches. In addition, the research findings and suggestions for the next researches were given place in this research.
Tiềm năng mới của năng lượng nguyên tử
Authors: Quang-Loc Nguyen , Nguyen Minh-Hoang
Published: September 2021

Mới đây, Việt Nam đã được bầu vào Hội đồng Thống đốc Cơ quan Năng lượng Nguyên tử Quốc tế (International Atomic Energy Agency, IAEA). Kể từ khi năng lượng nguyên tử được đem vào nghiên cứu và ứng dụng thành công trong lĩnh vực cung ứng năng lượng, nó đã trở thành một tia hi vọng mới cho sự phát triển của nhân loại. Tuy nhiên, các sự kiện liên quan đến năng lượng nguyên tử, như việc ném bom hạt nhân của quân đội Mỹ vào các thành phố của Nhật Bản năm 1945 cho đến thảm họa nhà máy nguyên tử Chernobyl và Fukushima Daiichi, đã cho thấy khả năng hủy diệt của năng lượng nguyên tử. Câu hỏi được đặt ra là: Đã 10 năm kể từ khi thảm họa Fukushima xảy ra, chúng ta đã tìm ra cách giải quyết những mối lo ngại về an toàn xã hội của năng lượng nguyên tử, như rủi ro nổ nhà máy, xử lý chất phóng xạ, hay kiểm soát chế tạo vũ khí hạt nhân, với các tiến bộ khoa học công nghệ hiện nay hay chưa?Bài viết này sẽ tóm tắt bản tường trình hội nghị ‘Thorium energy for the world’ (tạm dịch: năng lượng Thorium cho toàn cầu) và bàn luận về khả năng của khoa học và công nghệ trong việc kiểm soát và phát triển ngành công nghiệp năng lượng đầy triển vọng này.
CLEC2D expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: September 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of C-type lectin domain family 2, member D, encoded by CLEC2D when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, CLEC2D expression was significantly correlated with overall survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. CLEC2D may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
Uma proposta para a implementação da BNC-Formação 2019
Authors: Nakashima Rosaria Helena Ruiz , Lobo Matheus Pereira
Published: September 2021

Apresentamos uma interpretação para auxiliar na implementação da Resolução CNE/CP nº 2 de 20 de dezembro de 2019, que define as Diretrizes Curriculares Nacionais para a Formação Inicial de Professores para a Educação Básica e institui a Base Nacional Comum para a Formação Inicial de Professores da Educação Básica (BNC-Formação).
SPDEF expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: September 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of SAM pointed domain-containing ets transcription factor, encoded by SPDEF when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, SPDEF expression was significantly correlated with distant metastasis-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. SPDEF may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
kesetaraan gender dan implemenkasinya dalam hukum islam
Authors: dharul anugerah
Published: September 2021

AbstrakBanyak problematika selama ini yang menjadi perbincangan dalam dunia kehidupan sekarang ini. Bahkan problem yang sering timbul adalah masalah antara laki-laki dan perempuan dimana seorang laki-laki selalu menganggap bahwasanya seorang perempuan tak akan pernah mampu menandingi bahkan menyamaratakan apa yang di lakukan oleh laki-laki. Misalnya dalam hal bekerja,berfikir,bahkan meniti karir pun sering menjadi masalah yang sangat sulit untuk di hindari. Disamping itu,perempuan pun tak ingin merasa kalah,tak ingin terlihat lemah di depan laki-laki. Mereka merasa mereka mampu untuk melakukan bahkan melebihi dari apa yang di lakukan oleh laki-laki. Sehingga timbullah sebuah pertikaian diantara kedua golongan tersebut untuk menunjukkan siapa yang lebih layak untuk memenangkan perkelahian tersebut.Kesetaraan gender akan membawa kita kepada dunia yang beropini bahwasanya semua orang memiliki hak untuk melakukan apa pun tanpa melihat dari jenis kelamin yang di miliki. Seorang perempuan akan terus berusaha untuk menunjukkan bahwasanya dia bukanlah makhluk lemah yang hanya menghabiskan waktunya di rumah untuk melayani suaminya tanpa pekerjaan ataupun karir. Begitu juga laki-laki akan terus memberikan opini bahwa perempuan tak layak akan semua hal itu. Sehingga timbullah permasalahan yang mempermasalahkan siapakah yang akan menjadi pemimpin dalam sebuah perusahaan,negara,organisasi bahkan rumah tangga?.Dalam tulisan ini kita akan bersama-sama membahas tentang kesetaraan gender tersebut dalam dalam perspektif islam dan bagaimanakah cara untuk mengimplementasikannya dalam hukum islam. Dan apakah pandangan islam dalam hal tentang kesetaraan gender tersebut.
ARNTL expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: September 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of aryl hydrocarbon receptor nuclear translocator-like, encoded by ARNTL when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, ARNTL expression was significantly correlated with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. ARNTL may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
BUDAYA AMONG-AMONG DAN SLAMETAN DI JAWA
Authors: Rayhan Muhammad
Published: September 2021

Setelah agama islam masuk ke Indonesia pada abad 7-13 M, terjadi perubahan yang sangat drastis dalam system kepercayaan masyarakat Indonesia umumnya dan masyarakat jawa pada khususnya, karena islam berhasil perlahan mengambil hati masyarakatnya. Perkembangan dakwah islam di jawa memiliki proses yang unik, karena menghadapi kekuatan pra islam yang telah mengakar pada setiap spektrum kehidupan masyarakat. Para penyebar agama islam di pulau jawa tidak mudah untk menghilangkan dan menggeser budaya budaya yang telah diciptakan nenek moyang mereka pada masa pra islam. Maka dengan bentuk dan cara yang telah mengakar dalam kehidpan masyarakat tetap dipertahankan dengan arah dan tujuan dialihkan menuju yang bernuansa islami. Tetapi seiring berkembangnya zaman, budaya budaya masyarakat pulau jawa mengalami revolusi dalam bentuk, tata cara, dan tujuan pelaksanaanya. Sehingga tidak lagi dapat dikatakan sebaggai ajaran islam yang sesuai dengan apa yang tertera dalam Al Quran dan Hadist. Dalam artian bahwa budaya-budaya tersebut sudah tergolong dalam perbuatan yang syirik. Maka makalah ini mengkaji tentang budaya-budaya masyarakat pulau jawa khususnya among-among yang telah mengalami revolusi bentuk, tatacara, dan tujuan pelaksanaan, yang sudah tidak sesuai dengan syareat islam.
ALIRAN KEPERCAYAAN DAN KEBATINAN PANGESTU
Authors: Ramadhan Akbar , Fitriansyah Ainul Fuad
Published: September 2021

Artikel ini bertujuan menjelaskan pengertian dari aliran kepercayaan dan kebatinan, faktor-faktor terbentuknya, sejarah terbentuknya, dan konsep ketuhanannya. Dari artikel ini, kita melihat bahwasannya seluruh aliran kepercayaan dan kebatinan ingin yang namanya menghancurkan nilai-nilai agama islam, demi mengembalikan nilai-nilai nenek moyang mereka. Para pengikut aliran kepercayaan dan kebatinan banyak yang menggunakan paham panteisme, dan sinkritisme, dan paham-paham lainnya. Paham-paham inilah yang membentuk pergerakan aliran kepercayaan dan kebatinan.
Infants’ Neural Responses to Helping and Hindering Scenarios
Authors: Tan Enda , Hamlin Kiley
Published: September 2021

A growing literature suggests infants prefer prosocial others over antisocial others. Although recent studies have begun to explore the neural mechanisms underlying these responses (Cowell & Decety, 2015; Gredebäck et al., 2015), these studies were based on relatively small samples and focused on distinct aspects of sociomoral responding. The current preregistered study systematically examined infants’ neural responses both to prosocial/antisocial interactions and to prosocial/antisocial characters, using larger samples and two distinct age groups. We found that 6- (but not 12-) month-olds showed higher relative right frontal alpha power (indexing approach motivation) when viewing helping versus hindering scenarios. Consistent with past EEG work, infants showed no group-level manual preferences for the helper. However, analyses of infants’ neural responses toward images of the helper versus hinderer revealed that both 6- and 12-month-olds showed differential event-related potential (ERP) responses in the P400 and N290 components (indexing social perception) but not in the Nc component (indexing attentional allocation), suggestive that infants’ neural responses to prosocial versus antisocial characters reflect social processing. Together, these findings provide a more comprehensive account of infants’ responses to prosocial/antisocial interactions and characters, and support the hypothesis that both motivational and socially relevant processes are implicated in infants’ sociomoral responding.
Opinions of Primary School Teachers about Mathematics Teaching During the Covid-19 Pandemic Period
Authors: Kilinc Esma , Akkaya Sumeyra , Kapidere Metin
Published: September 2021

This study was conducted to reveal the aspect of distance education studies on teaching of mathematics with the evaluation by class teachers during the Covid-19 Pandemic period. 24 primary school teachers from Onikisubat district of Kahramanmaras province have participated in the research. The semi-structured interview form developed in line with the expert opinions was applied to the primary school teachers separately. This study was required in order to evaluate the events experienced in the distance education process due to the coronavirus pandemic and the effects of the pandemic on the field of education in the direction of the opinions of the class teachers. Qualitative research was carried out to interpret any situation from a different perspective in the study, and a case study has been conducted to reach the depth of the situation. As a data collection tool, a semi-structured interview form was prepared with the approval of expert opinions. After the data were brought together, content analysis was carried out by giving similar descriptions and describing them in a way that the reader could comprehend. The sample of the study consisted of teachers who personally experienced the process in the nearby environment, which consists of easily accessible situation sampling in order to accelerate the study. It is thought that it will be important to work properly execution of the processes that may occur in such times by determining the causes and consequences of the situations experienced in the field of education due to reasons such as the suspension of face-to-face education and the cessation of schools after the pandemic in the world. As a result of the research, suggestions will be made for the studies that can be done about teaching mathematics in distance education.
SRA1 expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: September 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of steroid receptor RNA activator 1, encoded by SRA1 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, SRA1 expression was significantly correlated with distant metastasis-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. SRA1 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
Pengaruh Tradisi kliwonan pada masyarakat cirebon
Authors: farrel farazandi
Published: September 2021

Artikel ini Membahas tentang Kliwonan atau tradisi yang biasa di lakukan tiap 35 hari sekali yaitu pada malam jumat kliwon. Pada tanggal tersebut masyarakat datang dari berbagai macam daerah dan kalangan untuk mengikuti acara kliwonan. Kota Cirebon merupakan kota wali karena kota ini merupakan pusat penyebaran islam di daerah jawa barat berkat kehadiran sunan gunung djati, tetapi apakah masyarakat Cirebon memegang teguh agama mereka atau terjadi akulturasi dalam agama mereka, Penulis Menggunakan metode studi literatur berdasarkan hasil yang diperoleh dari literatur penulis menyimpulkan bahwa tradisi kliwonan merupakan hasil percampuran antara tradisi nenek moyang terdahulu dengan agama islam dalam bentuk ziarah, tetapi tanpa mengetahu asal usul dari tradisi tersebut sehingga mereka hanya mengikuti tradsi orang-orang terdahulu sampai para tokoh terkemuka agama menentang ada nya kliwonan karena melakukan penyimpangan ajaran agama dan melakukan penghormatan dan pemujaan terhadap wali serasa mengalahkan pemujaan terhadap pencipta wali tesebut. Tetapi di lain kliwonan memberi keuntungan terhadap masyarakat yang tinggal di sekitar wilayah tersebut.
Determinants of the Socio-Economic Turnout Gap in OECD Countries
Authors: Bosancianu Constantin Manuel
Published: September 2021

Consistent evidence of variation in the participation gap between education or income groups in developing and developed democracies has begun to accrue. This points to varying disparities in participation between the haves and have nots that occasionally reach alarming levels, potentially triggering breakdowns in political representation. A few cross-sectional analyses identify institutional factors, such as voting complexity or state capacity, or economic ones, like income inequality, as driving the difference. Few explanations currently try to address why this participation gap varies over time. This is the question I take up here—I examine the extent to which the turnout gap has changed over time, and what the most robust explanations are for this temporal trend out of a set of factors grouped into 3 “families”. These sets of explanations refer to mechanisms that operate through voters’ (1) resources, (2) motivation to participate, or (3) likelihood of being mobilized at election time. Using an original pooled data set, with individual-level turnout data from 170–180 elections in 21 OECD countries, and party placement data from the MARPOR project, I show that the magnitude of the turnout gap between lower-SES and higher-SES citizens has increased over time, and that this trend has mainly been driven by the demobilization of lower-SES citizens. A two-stage analysis reveals that union density along with legislative fractionalization are the most consistent correlates of the participation gap between SES groups. The results are obtained from the most comprehensive evaluation to date of the way in which the SES-based turnout gap in advanced democracies has evolved over time. The findings contribute to our understanding of the long-term consequences for individual political behavior of institutional transformations in advanced democracies, and the democratic implications of these changes.
Validating a Scale for Measuring Students' Perspectives toward Global Citizenship: A Case at a Private University in Vietnam
Authors: Nguyen Minh Thanh
Published: September 2021

Globalization is one of the most significant phenomena of the 21st century, affecting many aspects of human society. In the wave of this influence, higher education institutions in many countries have adjusted themselves in order to prepare their students to be global citizens. However, research shows a need to evaluate whether the integration of global citizenship education is effective among different institutions and contexts. Many scholars are in favor of measuring students' perspectives as a solution. Additionally, although many organizations, such as UNESCO, and other researchers have investigated this issue, the measurement model is mainly designed for large-scale research. Therefore, this study aimed to validate a scale for measuring student perspectives toward global citizenship in a particular context of a university. Notably, the adopted scale measures global citizenship perspectives via three components: social responsibility, global competence, and global civic activism. In the study, each component was measured separately via three smaller measurement models. All the models were validated by using the PLS-SEM approach. The data for validating were collected from 171 students at a private university in Vietnam through an online survey. The result of data analysis suggested that the original scale (which was designed for the context of developed countries) could be employed in the context of developing countries. Nevertheless, some adjustments should be made in term of social responsibility and global competence.
MAKNA KEBAHAGIAAN MENURUT IMAM DI/TII S.M KARTOSUWIRYO
Authors: Mukhlis Romzi
Published: September 2021

Pembelajaran tentang Ideologi adalah sangat penting bagi kehidupan kita dimasa mendatang,karena kehidupan ini selamanya akan berulang-ulang.Tujuan dibuatnya jurnal ilmiah ini agar masyarakat dapat mengetahui lebih dalam Ideologi dri sejarah yang mulai disembunyikan dari kalangan terpelajar.oleh karena itu metode yang kami gunakan dalam membuat jurnal ilmiah kali ini adalah metode kualitatif .Kesimpulan dari jurnal ini adalah bahwa Ideologi DI/TII S.M. Kartosuwiryo adalah sebuah pemikiran yang diprakarsai oleh kekecewaannya tentang penjanjian yang diadakan di kapan Renvile
Resilience to stress in bipartite networks: Application to the Islamic State recruitment network
Authors: Wang Selena , Edgerton Jared
Published: September 2021

Networks are resilient to internal failures or external attacks. The resiliency is often beneficial, but there are scenarios where the collapse of a social system, network, or organization would be beneficial to society, such as the dismantlement of terrorist, rebel, or organized crime groups. In this article, we develop a methodology to estimate the effect of knockouts and apply our method to the Islamic State recruitment network. Using our novel application, we demonstrate how coordinated attacks against recruiters might reduce the Islamic State's ability to mobilize new fighters. This analysis has direct implications for studies of network resilience and terrorist recruitment.
Invisible gorillas in the mind: Internal inattentional blindness and the prospect of introspection training
Authors: Morris Adam
Published: September 2021

Much of high-level cognition appears inaccessible to consciousness. Countless studies have revealed mental processes -- like those underlying our choices, beliefs, judgments, intuitions, etc. -- which people do not notice or report, and these findings have had a widespread influence on the theory and application of psychological science. However, the interpretation of these findings is uncertain. Making an analogy to perceptual consciousness research, I argue that much of the unconsciousness of high-level cognition is plausibly due to internal inattentional blindness: missing an otherwise consciously-accessible internal event because your attention was elsewhere. In other words, rather than being structurally unconscious, many higher mental processes might instead be "preconscious", and would become conscious if a person attended to them. I synthesize existing indirect evidence for this claim, argue that it is a foundational and largely untested assumption in many applied interventions (such as therapy and mindfulness practices), and suggest that, with careful experimentation, it could form the basis for a long-sought-after science of introspection training.
Why Anti-Bias Interventions (Need Not) Fail
Authors: Schmader Toni , Dennehy Tara C. , Baron Andrew Scott
Published: September 2021

This manuscript was accepted for publication in Perspectives on Psychological Science on September 26, 2021. There is a critical disconnect between scientific knowledge about the nature of bias and how this knowledge gets translated into organizational de-biasing efforts. Conceptual confusion around what implicit bias is contributes to misunderstanding. Bridging these gaps is the key to understanding when and why anti-bias interventions will succeed or fail. Notably, there are multiple distinct pathways to biased behavior, each of which require different types of interventions. To bridge the gap between public understanding and psychological research, we introduce a visual typology of bias that summarizes the process by which group-relevant cognitions are expressed as biased behavior. Our typology spotlights cognitive, motivational, and situational variables impacting the expression and inhibition of biases while aiming to reduce the ambiguity of what constitutes implicit bias. We also address how norms modulate how biases unfold and are perceived by targets. Using this typology as a framework, we identify theoretically distinct entry points for anti-bias interventions. A key insight is that changing associations, increasing motivation, raising awareness, and changing norms are distinct goals, which require different types of interventions targeting individual, interpersonal, and institutional structures. We close with recommendations for anti-bias training grounded in the science of prejudice and stereotyping.
New insights into predictors of antihypertensive adherence: A mixed methods study of illness perceptions and the physician-patient relationship
Authors: Nikfarjam Mohammad Reza , Mohammadkhani Shahram , Moradi Ali Reza , Davarpasand Tahereh , Pearce Christina Joanne
Published: September 2021

Background: Low adherence to treatment is the most common cause of uncontrolled hypertension. Evidence suggests that illness perceptions and the physician-patient relationship may have a combined effect on treatment adherence.Aims: We investigated the roles of illness perceptions and the physician-patient relationship in medication and lifestyle modification adherence, and explained them using patients’ experiences with essential hypertension.Method: In this mixed methods explanatory sequential study, we used questionnaires to assess illness perceptions, the physician-patient relationship, and adherence to medication and lifestyle modification guidance (N = 112) in the first quantitative phase. Based on the results of regression analyses, the second qualitative phase was planned. We collected data from three patients through interviews, observations and journals, and conducted within-case and cross-case analyses. Finally, we integrated quantitative and qualitative findings.Results: The physician-patient relationship was an independent predictor of medication adherence (95% confidence interval [CI]: 0.29 to 5.89), whereas both illness perceptions (95% CI: −0.32 to −0.04) and the physician-patient relationship (95% CI: 1.05 to 9.48) were independent predictors of adherence to lifestyle modification guidance. Qualitative themes, reflecting the patients’ experience of the concepts explored in this study, explained the quantitative results. Mixing methods revealed high consistency between quantitative and qualitative findings.Limitations: Limitations are inability to infer causal associations among variables and indirect measurement of medication adherence.Conclusion: Shared decision making on antihypertensive medications promotes medication adherence. Specifically, the illness perception, perceived illness controllability, and non-judgemental patients’ acceptance within a satisfying physician-patient relationship empower patients to adhere to lifestyle modification guidance.
Police Ten 7 feeds racial stereotypes of Māori and Pacific peoples in Aotearoa New Zealand
Authors: Yan Roger , Rapana Wetini Atutahi , Waitoki Waikaremoana , McCreanor Tim , Barnes Angela Moewaka , Taumoepeau Mele , Winter Taylor , Riordan Benjamin , Dirks Kim , Phillips Justin , Hunter John , Arahanga-Doyle Hitaua , Scarf Damian
Published: September 2021

In a recent tweet, Auckland City Councillor Efeso Collins asked Television New Zealand (TVNZ) to drop Police Ten 7, arguing that it “…feeds on racial stereotypes”. Both the Chief Executive of the company behind Police Ten 7, and a former host, defended the show by suggesting that it provides an accurate portrayal of crime in Aotearoa New Zealand. In the current study, we coded a selection of episodes of Police Ten 7 from 2011 through to 2021. We had a single hypothesis: that Māori and Pacific peoples will be more likely to be depicted as committing aggressive crimes than Pākehā suspects. Consistent with our hypothesis, Māori and Pacific peoples were markedly more likely to be depicted committing aggressive offences than Pākehā.
Unconscious Knowledge of Rewards Guides Instrumental Behaviors via Conscious Judgments
Authors: Jurchiș Răzvan
Published: September 2021

The demonstration that unconscious learning supports instrumental behaviors (i.e., choosing the stimuli that lead to rewards) is central for the tenet that unconscious cognition sustains human adaptation. Recent studies, using reliable subliminal conditioning paradigms, have found evidence against unconscious knowledge sustaining accurate instrumental responses. The present preregistered study proposes an alternative paradigm, in which unconscious processing is stimulated not by subliminally exposing the predictive (conditioned) stimuli, but by employing predictive regularities that are complex and difficult to detect consciously. Participants (N = 211) were exposed to letter strings that, unknown to them, were built from two complex artificial grammars: a “rewarded’’ or a “non-rewarded” grammar. On each trial, participants memorized a string, and subsequently had to discriminate the memorized string from a distractor. Correct discriminations were rewarded only when the identified string followed the rewarded grammar, but not when it followed the non-rewarded grammar. In a subsequent test phase, participants were presented with new strings from the rewarded and from the unrewarded grammar. Their task was now to directly choose the strings from the rewarded grammar, in order to collect more rewards. A trial-by-trial awareness measure revealed that participants accurately choose novel strings from the rewarded grammar when they had no conscious knowledge of the grammar. The awareness measure also showed that participants were accurate only when the unconsciously learned grammar led to conscious judgments. The present study provides an alternative to subliminal conditioning paradigms and shows that unconscious knowledge can guide instrumental responses.
Neural Mechanisms of Intimate Partner Aggression
Authors: Chester David , Martelli Alexandra , West Samuel James , Lasko Emily , Brosnan Phoebe , Makhanova Anastasia , Meltzer Andrea L. , McNulty James K.
Published: September 2021

People sometimes hurt those they profess to love; yet our understanding of intimate partner aggression (IPA) and its causes remains incomplete. We examined brain activity using functional magnetic resonance imaging (fMRI) in an ethnically and racially diverse sample of 50 female-male, monogamous romantic couples as they completed an aggression task against their intimate partner, a close friend, and a different-sex stranger. Laboratory and real-world IPA were uniquely associated with altered activity within and connectivity between cortical midline structures that subserve social cognition and the computation of value. Men’s IPA most corresponded to lower posterior cingulate reactivity during provocation and women’s IPA most corresponded to lower ventromedial prefrontal cortex activity during IPA itself. Actor-partner independence modeling suggested women’s IPA may correspond to their male partner’s neural reactivity to provocation. Broadly, these findings highlight the importance of self-regulatory functions of the medial cortex and away from effortful inhibition subserved by dorsolateral cortices.