bluuebunny/crossref_metadata_2025 huggingface dataset:
Which is the best prosthesis in an isolated or combined tricuspid valve replacement?
Authors: Liu Peng , Xia Dong-Sheng , Qiao Wei-Hua , Hu Dan , Ahmed Adnan , Dong Nian-Guo , Chen Si
Published: July 2020

OBJECTIVES

The debate concerning the optimal choice of tricuspid position continues. We compared the long-term results of mechanical and biological prostheses in patients who underwent isolated or combined tricuspid valve replacement, at 2 major cardiac surgical centres in central China.

METHODS

From January 1999 to December 2018, 338 patients underwent tricuspid valve replacement. Patients were divided into an isolated group or a combined group according to whether their surgery was combined with a left heart valve surgery. Mechanical tricuspid valve replacement was performed in 142 patients (isolated group: 41 vs combined group: 101), and 196 patients underwent bioprosthetic tricuspid valve replacement (isolated group: 145 vs combined group: 51). Operative results, long-term survival and tricuspid valve-related events were compared.

RESULTS

Early mortality in the combined group was higher (n = 6, 4%) than that in the isolated group (n = 3, 2%), but no significant difference was observed between the mechanical and biological subgroups. In the isolated group, there was a higher event-free rate in the biological subgroup than in the mechanical subgroup (P = 0.042) and a similar result was also observed for patients without Ebstein’s anomaly (P = 0.039). In the combined group, no significant difference was observed (P = 0.98). Survival rates were similar between the mechanical and biological subgroups in both the isolated (P = 0.54) and combined (P = 0.81) groups. Mechanical valves in isolated tricuspid valve replacement were more prone to valve thrombosis and bleeding.

CONCLUSIONS

Every decision regarding tricuspid valve prostheses should be individualized, but biological prostheses may be an optimal choice for patients, especially for patients without Ebstein’s anomaly, in isolated tricuspid valve replacement.
Sequencing smart: De novo sequencing and assembly approaches for a non-model mammal
Authors: Etherington Graham J , Heavens Darren , Baker David , Lister Ashleigh , McNelly Rose , Garcia Gonzalo , Clavijo Bernardo , Macaulay Iain , Haerty Wilfried , Di Palma Federica
Published: July 2020

Background

Whilst much sequencing effort has focused on key mammalian model organisms such as mouse and human, little is known about the relationship between genome sequencing techniques for non-model mammals and genome assembly quality. This is especially relevant to non-model mammals, where the samples to be sequenced are often degraded and of low quality. A key aspect when planning a genome project is the choice of sequencing data to generate. This decision is driven by several factors, including the biological questions being asked, the quality of DNA available, and the availability of funds. Cutting-edge sequencing technologies now make it possible to achieve highly contiguous, chromosome-level genome assemblies, but rely on high-quality high molecular weight DNA. However, funding is often insufficient for many independent research groups to use these techniques. Here we use a range of different genomic technologies generated from a roadkill European polecat (Mustela putorius) to assess various assembly techniques on this low-quality sample. We evaluated different approaches for de novo assemblies and discuss their value in relation to biological analyses.

Results

Generally, assemblies containing more data types achieved better scores in our ranking system. However, when accounting for misassemblies, this was not always the case for Bionano and low-coverage 10x Genomics (for scaffolding only). We also find that the extra cost associated with combining multiple data types is not necessarily associated with better genome assemblies.

Conclusions

The high degree of variability between each de novo assembly method (assessed from the 7 key metrics) highlights the importance of carefully devising the sequencing strategy to be able to carry out the desired analysis. Adding more data to genome assemblies does not always result in better assemblies, so it is important to understand the nuances of genomic data integration explained here, in order to obtain cost-effective value for money when sequencing genomes.
Asset Freezing at the European and Inter-American Courts of Human Rights: Lessons for the International Criminal Court, the United Nations Security Council and States
Authors: Birkett Daley J
Published: July 2020

This article examines the human rights implications of the asset freezing processes available to the International Criminal Court and the United Nations Security Council. It does so through the lens of the case law of the European Court of Human Rights and the Inter-American Court of Human Rights, from whose jurisprudence, although not uniform, a number of principles can be distilled. By scrutinising a series of cases decided under the European Convention on Human Rights and American Convention on Human Rights, respectively, the article demonstrates that the rights to the peaceful enjoyment of property and to respect for one’s private and family life, home and correspondence are necessarily implicated by the execution of asset freezing measures in criminal and administrative contexts. The article concludes that, considering the human rights constraints placed on the exercise of their powers, both the International Criminal Court and United Nations Security Council, as well as States acting at their request, must pay attention to this case law with a view to respecting the human rights of those to whom asset freezing measures are applied.
US counterterrorism in the Sahel: from indirect to direct intervention
Authors: Tankel Stephen
Published: July 2020

The massive expansion and evolution of United States security cooperation under the auspices of the ‘war on terror’ remains overlooked in the counterterrorism and interventions literature. The Sahel provides a useful region in which to explore the constitutive effects of such cooperation and its evolution because the US has always pursued an ‘economy of force’ mission there. In this article, I focus mainly on the constitutive effects of US indirect military intervention in the Sahel after 9/11, and subsequent more direct military intervention following the outbreak of civil war in Mali. The indirect intervention by the United States to build the capacity of local forces in Mali, where jihadists were based, failed because of the dissonant relationship between the two countries. This led the United States to intervene more directly in the region, including through its cooperation with and support for French and Nigerien forces. The nature of this more direct military intervention was also informed by evolving US experiences working by, with and through partner forces in other parts of the world.
Spinoza's not so quiet influence: the Theological-political treatise 350 years on
Authors: Epstein Charlotte
Published: July 2020

In this review essay I reflect on the centrality of Spinoza's thought to political modernity on the combined occasion of the 350th anniversary of the original publication of his first political treatise, the Tractatus theologico–politicus, and of the publication this year of George Eliot's English translation of Spinoza's Ethics, which had been lying in a drawer for almost a century and a half. His influence is both substantial and methodological. It owes to the singular way in which he calibrated the relationship between reason, or the natural human need to understand, and faith, or the need to believe. But, over a century before the social sciences were invented, Spinoza also laid the foundations for the interpretative methods that would become central to these sciences and to the study of international politics. He remains essential reading for understanding our world.
Introduction to “Reproduction: The Female Perspective from an Integrative and Comparative Framework”
Authors: Hayssen Virginia , Orr Teri J
Published: July 2020

Synopsis

This compendium is from a symposium about reproductive biology from the female perspective, but what do we mean by the female perspective? Most obviously, since all of our speakers, and most of our contributors, are female, one meaning is that the female perspective is the view of female scientists. Our diverse contributors are from a spectrum of academic ranks (post-docs to chaired professors) and study a range of animal taxa from insects to mammals. More importantly, we want to examine reproductive biology from the perspective of female organisms themselves. What happens when we examine social behavior, physiology, or ecology strictly from the viewpoint of females? In many cases, the female-centric perspective will alter our prior interpretations. For example, with deoxyribonucleic acid fingerprinting, differences between genetic and behavioral mating-systems became obvious. The scientific community came to realize that assessing parentage is the definitive way to categorize mating systems since using male-mating strategies resulted in flawed conclusions; in fact, the female selection of which sperm is involved in conception is more important in determining parentage than mating events per se. Perhaps parentage systems rather than mating systems would be more appropriate. This difference in interpretation relative to methodology exemplifies how behavioral ecology might change if we examine systems from the female perspective; similar changes may occur for other fields. Another example comes from studies of whole-organism performance. Here, jumping, running, and swimming have been measured in males, usually with the deliberate removal of females and the major facet of female physiology, that is, reproduction. However, female biology may actually set the limits of performance given the need to carry extra weight and the extensive changes in body shape required for reproduction. Female performance is a valuable area for research. In fact, novel insights into metabolic ceilings arose from examining energetics, including metabolic rates, during lactation. In the symposium and the associated papers, our contributors explored the various ways in which a female-focused framework shifts our research conclusions and programs. As a way forward, we also include a table of sex-neutral terminology to replace terms that are currently androcentric or value-laden.
Double transcatheter balloon-expandable valve implantation for severe valve dysfunction in high-risk patients: initial experience
Authors: Bastos Filho João Bosco Breckenfeld , Sampaio Roney Orismar , Cividanes Felipe Reale , Rosa Vitor Emer Egypto , da Costa Leonardo Paim Nicolau , Vieira Marcelo Luiz Campos , Jatene Fabio Biscegli , Tarasoutchi Flavio , Palma José Honório , Ribeiro Henrique Barbosa
Published: July 2020

OBJECTIVES

Concomitant valvular heart valve disease is a frequent finding, with higher morbidity and mortality among patients undergoing redo surgical procedures. Our goal was to report our initial experience with combined transcatheter Inovare bioprosthesis implants for severe valve dysfunction.

METHODS

Among 300 transcatheter procedures, a total of 6 patients had concurrent simultaneous transcatheter bioprosthesis implants for severe mitral bioprosthesis failure (valve-in-valve), with a second valve procedure that included native aortic (n = 2) or degenerated bioprostheses in the aortic position (n = 4). During the procedures, all patients were treated with a balloon-expandable Inovare transcatheter valve, using the transapical approach.

RESULTS

Patients were highly symptomatic [New York Heart Association (NYHA) functional class IV: 100%], with a mean age of 62 ± 5 years, yielding a mean European System for Cardiac Operative Risk II (EuroSCORE II) of 24.0 ± 10.1%. There was a mean of 1.6 ± 0.4 prior valve operations/patient, with a median time from prior mitral bioprosthesis surgery of 13.0 (9.2–20.0) years. Device success was 100% according to the Mitral Valve Academic Research Consortium and the Valve Academic Research Consortium-2 criteria. During the hospital stay, only 1 patient required dialysis, and the median intensive care unit and hospital lengths of stay were 5.0 (3.2–6.7) days and 16.0 (12.2–21.2) days, respectively. No deaths occurred at 30 days; at a median follow-up of 287 (194–437) days, 1 patient died of a non-cardiac cause and the rest of patients were in NYHA functional class I or II, with normofunctioning bioprostheses.

CONCLUSIONS

Transcatheter double valve interventions using the Inovare bioprosthesis in this initial series were shown to be a reasonable alternative to redo surgical operations. The short- and mid-term clinical and echocardiographic outcomes demonstrate promising results, although future studies with a larger number of patients and longer follow-up are warranted.
Prolonged air leak after reoperative pulmonary resection (with prior ipsilateral chest surgery)
Authors: Murakami Kotaro , Hamaji Masatsugu , Morita Satoshi , Ueno Kentaro , Nakajima Daisuke , Ohsumi Akihiro , Menju Toshi , Date Hiroshi
Published: July 2020

Reoperative pulmonary resection (with prior ipsilateral chest surgery) has been reported to be associated with a high rate of postoperative complications. The objective of this study was to evaluate prolonged air leak (PAL) after reoperative pulmonary resections. We conducted a single-centre retrospective analysis on 100 consecutive patients undergoing ipsilateral reoperative pulmonary resection at our institution between March 2012 and February 2020. We investigated the incidence of PAL after reoperative pulmonary resections in comparison to that after first operations and analysed potentially relevant factors of PAL after reoperations. After reoperations, the incidence of PAL was 24%. The incidence of PAL after reoperations was significantly higher than that after first operations (P < 0.01). On multivariable analysis, anatomical resection (P = 0.03) and thoracotomy approach (P = 0.02) were found to be significant factors associated with the occurrence of PAL, and age was a significant factor associated with chest tube duration (P < 0.01) and length of hospital stay (P < 0.01) after reoperative pulmonary resection. Our study identified significant risk factors of PAL after reoperative pulmonary resections, which would be an important step towards improved management of patients undergoing reoperative pulmonary resections.
Erratum: Energy Minimization, Periodic Sets, and Spherical Designs
Authors: Coulangeon Renaud , Schürmann Achill
Published: July 2020

In [ 3] we considered energy minimization of pair potentials among periodic sets of a fixed-point density. For a large class of potentials we presented sufficient conditions for a point lattice to give a local optimum among periodic sets. We hereby, in particular, derived a local version of Cohn and Kumar’s conjecture [ 1, Conjecture 9.4] by which the hexagonal lattice $\textsf{A}_2$, the root lattice $\textsf{E}_8$, and the Leech lattice are globally universally optimal. Latter conjecture has recently been proved for $\textsf{E}_8$ and the Leech lattice by Cohn et al. [ 2].
Compatibility of Bifenazate andPhytoseiulus persimilisfor Management of Twospotted Spider Mites in North Carolina Staked Tomatoes
Authors: Bilbo Tom R , Walgenbach James F
Published: July 2020

The twospotted spider mite (TSSM, Tetranychus urticae Koch) is a key pest of tomatoes (Solanum lycopersicon L. [Solanales: Solanaceae]) in North Carolina, and its management has relied principally on synthetic acaricides. Augmentative biological control of TSSM is a commonplace and effective management strategy in greenhouses worldwide, but in field-grown vegetable crops biocontrol of TSSM is poorly developed. We conducted small-plot field experiments in 2016 and 2019 to test the ability of the predatory mite, Phytoseiulus persimilis Athias-Henriot, to establish, disperse, and reduce TSSM in staked tomatoes, as well as test their compatibility with a commonly used reduced-risk acaricide, bifenazate (Acramite). Across both years, the most effective treatment for reducing TSSM was the combination of P. persimilis + Acramite. Phytoseiulus persimilis successfully established both years, but its population growth and dispersal were greater in 2016 than 2019. Acramite alone significantly reduced TSSM pressure in 2019 and P. persimilis alone did not reduce TSSM pressure below the control in either year. However, results in 2016 were influenced by the eventual dispersal of P. persimilis into all experimental plots, despite efforts to hinder their movement with corn barriers. Results in 2019 were influenced by the late-season invasion of TSSM into the trial, which delayed P. persimilis releases and influenced their establishment and growth. This study is the first to demonstrate the utility and limitations of P. persimilis in staked field tomatoes, which is a promising option for growers to manage TSSM in tomatoes in the southeast United States.
Necrotizing fasciitis from perforated sigmoid diverticulitis with subsequent pyoderma gangrenosum: a case report
Authors: Benesch Matthew G K , Bussey Angela S D
Published: July 2020

Postsurgical pyoderma gangrenosum is a very rare form of cutaneous ulceration that is poorly recognized outside of dermatology and in some circumstances has been mistaken for necrotizing fasciitis. Here, we present a rare case of sigmoid diverticulitis with left ureter obstruction that perforated and quickly progressed into necrotizing fasciitis of the left buttock and leg via retroperitoneal spread in an immunocompetent patient. Nearly a year after intense surgical therapy, the patient rapidly developed ulcerating lesions over the left hip which presented a diagnostic dilemma. These were initially thought to represent Marjolin’s ulcers, which would require aggressive local excision. Multiple diagnostic imaging tests and biopsies eventually confirmed pyoderma gangrenosum, which was successfully treated with immunosuppressive therapy. This case highlights the need for a very broad differential diagnosis and wide expertise consultation when managing unusual postsurgical complications, especially when treatment modality critically depends on the correct diagnosis.
Transverse colon volvulus in a patient with autism
Authors: Shah Rony , Klumpp Linda , Negron-Diaz Juan , Carmain Torr , Jordan Jeffrey ,   HCA Healthcare/USF Morsani College of Medicine GME Programs at Citrus Memorial Hospital, Inverness, Florida
Published: July 2020

Transverse colon volvulus is an extremely rare cause of bowel obstruction with approximately 100 cases reported in literature. Transverse colon volvulus presents with signs and symptoms of large bowel obstruction, but it can become a surgical emergency due to bowel infarction or peritonitis. We present a rare case of transverse colon volvulus in a 36-year-old male patient with severe autism. We hope this case report will raise awareness of this disease.
中国成人谷类和膳食纤维摄入现状与趋势(1982–2015)
Authors: Dongmei Yu , Liyun Zhao , Wenhua Zhao
Published: July 2020

本研究的目的是分析1982-2015 年中国20 岁及以上成人的谷类

和膳食纤维摄入状况、特点及消费趋势。数据来自五轮中国居民营养

与健康调查的膳食数据，膳食数据的收集均采用连续3 天家庭食物称

重法和24 小时膳食回顾法。结果表明，2015 年中国20 岁及以上成人

人均谷类食物摄入量为281.1 克/日(大米145.6 克/日、小麦粉120.7

克/日、其他谷类14.8 克/日)；膳食纤维摄入量为9.7 克/日，其中3.8 克

来自谷类食物，约占成人膳食纤维总摄入量的40%；我国成人膳食纤

维的另一个主要来源是蔬菜和水果。自1982 年以来，中国居民的谷类

和膳食纤维摄入量呈下降趋势，而精制谷物的消费比例增加。为了促

进中国居民达到全谷物和膳食纤维的推荐摄入量，建议增加全谷物产

品的供应以及公众宣传教育。
Profiling the Lolium perenne Microbiome: From Seed to Seed
Authors: Tannenbaum Ian , Kaur Jatinder , Mann Ross , Sawbridge Timothy , Rodoni Brendan , Spangenberg German
Published: July 2020

Lolium perenne (perennial ryegrass) is a common temperate pasture grass species and is favored by dairy farmers. Commercially, the known association with the mutualistic endophytic fungus Epichloë festucae subsp. lolii is used to enhance insect resistance of host plants. Knowledge of other members of the microbiome and their functions are limited. Sequencing of the V4 region of the 16S ribosomal RNA gene was used to examine the bacterial microbiome of perennial ryegrass (Alto) seed (generation 1 [G1]), subsequent mature plants grown in soil and sand, and seed (generation 2 [G2]) from crosses of these mature plants. The G1 microbiome was dominated by the class Gammaproteobacteria. The mature plant microbiomes were far more diverse, comprising up to 37 classes inclusive of Gammaproteobacteria. Different growth media yielded different microbiome profiles in mature plants. The G2 microbiome, similar to the G1 microbiome, was dominated by Gammaproteobacteria as the primary constituent, with additional supplementation from class Bacilli. This suggests the continuation of a core microbiome which persists from seed through plant maturation to seed. This study sheds new light on the hereditability of perennial ryegrass bacterial microbiomes and has identified some operational taxonomic units of potential commercial significance due to their seed transmissibility, and their roles are currently being explored.
1-6OBSTRUCTIVE SLEEP APNEA IN RESISTANT HYPERTENSION
Authors: Pinzon Rizaldy
Published: July 2020

Background:

HTN is considered resistant when the blood pressure (BP) remains above goal (≥140/90 mmHg) despite lifestyle modification and administration of three antihypertensive agents of different classes, including a diuretic. Obstructive sleep apnea (OSA) is associated with hypoxia, hypercapnia, arousal, and fluctuations of intrathoracic pressure which all contribute to the sympathetic overdrive. The association of resistant hypertension and obstructive sleep apnea are documented in several previous studies. The data from Indonesia are very limited.

Aim:

Measure the association between obstructive sleep apnea and resistant hypertension.

Method:

This is a cross-sectional study. The presence of sleep apnea is measured with complete polysomnography (PSG). Resistant hypertension is generally defined as uncontrolled clinic blood pressure (>140/90 mm Hg) after treatment with three or more antihypertensives. The data about medication were obtained from computerized electronic prescription. The data of adherence are measured with the Morisky Adherence scale. We measure the apnea and hypopnea events per hour, which is called the apnea-hypopnea index (AHI), is used to grade OSA. The data presented in a systematic table.

Result:

The data were obtained from 12 patients with resistant hypertension. The data consist of 8 male and four female. Complete PSG was recorded in all subjects. The result showed that ten patients have obstructive sleep apnea. Severe obstructive sleep apnea (AHI> 30) presence in 7 patients. The data of CPAP/ APAP usage are obtained from 4 subjects. The result showed that blood pressure control is much better after the use of CPAP/ APAP.

Conclusion:

OSA is very prevalent in resistant hypertension. OSA should be evaluated in patients with resistant hypertension.
1-9HYPERTENSION AND ATRIAL VOLTAGES AT ATRIAL APPENDAGES
Authors: Iswandi Cindya Perthy , Starreveld Eliene , Groot Natasja MS de
Published: July 2020

Background:

Hypertension has been linked with alterations of atrial electrophysiology, which related to the substrate of atrial fibrillation. However, atrial voltages at atrial appendages and their relationship with hypertension remain undiscovered. The study aimed to investigate atrial voltages at both right and left atrial appendages (RAA and LAA) and their correlations with hypertension in patients with underlying heart disease.

Materials & Methods:

Subjects with ischemic and/or valvular heart disease undergoing cardiac surgery at Erasmus Medical Center Rotterdam were included. After the heart was exposed during open chest surgery, high-resolution epicardial mapping of the LAA and the RAA during sinus rhythm was performed before starting cardiopulmonary bypass. Custom-made software was used to measure atrial voltages. A history of hypertension was obtained from the electronic medical record before undergoing surgery.

Results:

Among 133 patients undergoing cardiac surgery, 88 patients (66%) had hypertension. Atrial voltages at the LAA were higher in hypertensive patients compared to non-hypertensive patients (median = 5.36 vs 3.59 p < 0.05), also a correlation between hypertension and atrial voltages at the LAA was identified (r = 0.247, p < 0.05). On the other hand, atrial voltages at the RAA were comparable between hypertensive and non-hypertensive patients (median = 4.30 vs 3.96, p > 0.05), without any correlation was found between hypertension and atrial voltages at the RAA.

Conclusions:

Atrial voltages at the LAA are higher compared to the RAA within hypertensive patients. Hypertension is also correlated with higher atrial voltages at the LAA. High atrial voltages at the LAA might be associated with structural changes of the LAA impacted by systemic hypertension.
2-2PROFILE OF RESISTANT HYPERTENSION IN THE UNIVERSITY CHRISTIAN OF INDONESIA GENERAL HOSPITAL IN 2019
Authors: Suling Frits R.W. , Hutabarat Hardi , Kramasanjaya Ida Bagus Udayana , Agustian Zega
Published: July 2020

Hypertension is one of the leading causes of mortality and morbidity in Indonesia. Resistant hypertension is a case of hypertension whose blood pressure remains high, after a change in lifestyle and obtaining management of 3 anti-hypertensive drugs with optimal doses with a different mechanism of action. The exact prevalence of HR is not known with certainty. The lack of data on the prevalence of resistant hypertension is the aim of this study to complete the data on the prevalence of resistant hypertension in UKI General Hospital. This research is descriptive. Data is taken from UKI General Hospital medical records from January to December 2019 with inclusion and exclusion criteria. Of the 1,030 in patients with hypertension, 139 patients are suffering from resistant hypertension. With the number of men and women not very different, the average age is 58 years, and most cases are in the age group> 65 years. Chronic kidney failure (CKD) is the most common comorbid disease, followed by DM and heart failure. Patients with more resistant hypertension have very high initial blood pressure, and most use a combination of 3 drugs to control their blood pressure.
2-3THE EFFECT OF IBUPROFEN VS ACETAMINOPHEN ON POSTPARTUM BLOOD PRESSURE IN WOMAN WITH HYPERTENSIVE DISORDER OF PREGNANCY: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIAL
Authors: Leonardo  , Iskandar Archie F. , Ivan Ignatius , Budiman Fanny , Ruby Rivaldi , Ampri Irfan A. H.
Published: July 2020

Introduction:

The American College of Obstetricians and Gynecologists (ACOG) suggested replacing NSAIDs with other analgesics for pain relief management of hypertension in pregnancy because of the risk of elevating blood pressure. However, the evidence to support this issue remains unclear. This systematic review aims to investigate the risk of elevated postpartum blood pressure for the woman with hypertensive disorders of pregnancy treated with ibuprofen compared to acetaminophen.

Methods:

We used Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines during our literature search. Pubmed, EBSCOhost, and Proquest were used for database searching up to December 2019. We included studies with the following criteria: English article, human study; randomized controlled trial; relevant patient characteristics; and outcome assessment. Two authors independently assessed the quality of the included study using Cochrane Risk of Bias Tool 2.0 covering six domains with scores of “low,” “high,” “unclear.”

Results:

We identified a total of 79 studies from search strategies. We found four studies that have a relevant issue. One study has an unclear risk of selection bias. Another study has a high risk of performance bias. Moreover, all studies suggested having an unclear risk of detection bias. All studies are randomized controlled trials with a total of 345 participants treated with ibuprofen or acetaminophen. Evaluation for a difference of mean arterial pressure after treatment showed insignificant difference between study groups. Other studies reported measurement with a mean maximum of systolic and diastolic blood pressure and also revealed an insignificant difference between group. Only 1 study suggesting the risk of using ibuprofen for elevating blood pressure which resulted from a significant difference between study group comparing number of patients having blood pressure ≥ 150/100 mmHg after treatment.

Conclusion:

Despite limited studies, we concluded that most studies showed insignificant difference between the use of NSAIDs particularly ibuprofen, compared with other analgesic such as acetaminophen for the risk of elevating blood pressure in woman with hypertensive disorder of pregnancy. Further studies with more extensive trials were necessary to elucidate better quality of evidence.
2-8THE EFFECT OF LACTOBACILLUS CONSUMPTION ON SYSTOLIC AND DIASTOLIC BLOOD PRESSURE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Winston Kevin , Dewangga Raditya , Ilhami Lazuardi G
Published: July 2020

Introduction:

Gut microbiota has been shown to play an increasingly important role in health with recent data suggesting that probiotics exert ACE-inhibitory activity. As a result, several clinical trials were conducted to assess the effect of probiotics, such as lactobacillus on blood pressure. However, many of these trials provided inconclusive results.

Objective:

To conduct meta-analysis of clinical trials that assess the effect of Lactobacillus probiotic supplementation in lowering systolic and diastolic blood pressure.

Methods:

A comprehensive literature search using PubMed, Scopus, Cochrane Library, EBSCOhost, ProQuest, and JSTOR online for randomized controlled studies comparing the effect of Lactobacillus probiotic versus placebo in lowering blood pressure was performed up to December 2019. The measured outcomes were mean changes in systolic and diastolic blood pressure. Meta-statistics were done using the random-effects model.

Result:

Fourteen randomized clinical trials involving a total of 955 patients met the inclusion criteria. Supplementation of Lactobacillus probiotic produced a statistically significant difference in systolic blood pressure by −2.05 mmHg (95% CI −3.48 to −0.63) and diastolic blood pressure by −2.00 mmHg (95% CI −3.36 to −0.64) when compared with the placebo group.

Conclusion:

Supplementation with Lactobacillus probiotics may lower systolic and diastolic blood pressure by a slight degree. More high-quality studies are needed to confirm this finding.
2-9THE USE OF IBUPROFEN AS POSTPARTUM ANALGESIC IN WOMEN WITH HYPERTENSIVE DISORDER OF PREGNANCY: A SYSTEMATIC REVIEW
Authors: Rudiatmoko Diar Riyanti , Amanda Lia
Published: July 2020

Background:

Postpartum women are commonly prescribed with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, which is effective for pain management. However, NSAIDs were known to induced hypertension. Thus, the use of NSAIDs in postpartum women with hypertension is still controversial due to a lack of evidence. This study aims to identify the use of ibuprofen as postpartum analgesics in women with hypertensive disorder of pregnancy.

Methods:

A systematic literature search was conducted using specific keywords with medical subheading (MeSH) terms on PubMed, EBSCOhost, Cochrane, and ProQuest for primary studies published from January 2009 – December 2019. Two authors independently screened and assessed the potential studies using inclusion criteria. The quality of the randomized controlled trial studies was assessed with JADAD scale and Newcastle-Ottawa Quality Assessment Scale (NOS) was used to assess the quality of cohort studies.

Result:

After screening the literature, four randomized controlled trials (RCTs) and two retrospective cohort studies were identified, comprising of 895 total patients. All studies except one RCT showed that ibuprofen did not increase postpartum blood pressure in postpartum women with hypertensive disorders of pregnancy compared with women without the exposure of NSAIDs. Those who were receiving ibuprofen showed no difference in postpartum mean arterial pressure (MAP) compared to control. No significant adverse events were also found in postpartum women.

Discussion:

This review demonstrates that the use of ibuprofen may be beneficial and can be used for postpartum women with hypertension. However, further studies with a larger population are still needed to confirm these results.
3-3ELEVATED MEAN PLATELET VOLUME AND RETINAL VEIN OCCLUSION IN HYPERTENSIVE PATIENTS: A META-ANALYSIS
Authors: Shabrina Nadine Nurani , Sawitri Rakhma Dyah , Shabrina Tiffanny Nur , Ningrum Nurul Rahayu
Published: July 2020

Background:

In comparison to smaller ones, larger platelets indicate altered reactivity and aggregation. Mean platelet volume (MPV), knowingly used to assess the size, is significantly elevated in hypertension. High MPV is equivalent to a high risk of thrombotic events. Retinal vein occlusion (RVO) is one of the most common extracardiac complications of hypertension, which may lead to vision loss. Assessment of MPV may help to determine the development of the disease.

Objective:

We aimed to analyze if elevated MPV was associated with the incident of RVO, particularly in hypertensive patients.

Method:

A literature search was conducted through PubMed, Cochrane, and Science Direct for primary studies. The abstracts and full text were scanned for potentially relevant articles that fulfilled the inclusion criteria. The quality assessment was done using the Newcastle-Ottawa Quality Assessment Scale (NOS) for case-control studies. We analyzed the data using STATA 14.1.

Result:

Four studies (363 RVO patients and 256 controls) were incorporated into this meta-analysis. Due to the high heterogeneity, a random-effects model was used to calculate the pooled SMD and corresponding 95% confidence intervals. Results have indicated significant increase of MPV levels (SMD = 1.008, 95% CI 0.819–1.197, P < 0.001) and insignificant increase of platelet count levels (SMD = 0.149, 95% CI 0.016–0.313, P = 0.076) in hypertensive patients with RVO compared to controls.

Conclusion:

We found that MPV is strongly associated with the presence of RVO in hypertensive patients. Further studies are required to ascertain the potential clinical use of this simple and relatively inexpensive marker in RVO diagnosis.
3-5IMPROVING HYPERTENSION CONTROL THROUGH GUIDELINE-BASED EDUCATIONAL CARD IN EAST BORNEO PRIMARY HEALTH CARE
Authors: Jhundy B.W. , Siahaan W.F. , Dachi Y.O. , Lestari R.H.D.
Published: July 2020

Background:

Hypertension is a modifiable risk factor of mortality and disabilities around the globe. Its prevalence has been increasing in the last decade without adequate awareness and control in developing countries. Improving hypertension control is an essential strategy to prevent further Hypertension-Mediated Organ Damage.

Objective:

This study aimed to investigate the effectiveness of Guideline-based educational cards in controlling essential hypertension in East Borneo Primary Health Care.

Method:

Patients with essential hypertension enrolled in this study from February to April 2019. Patients were given a card that consists of their targetted blood pressure, blood pressure, and treatment changes during visits, lifestyle modifications, and additional information about blood pressure management. The physician orally informed all of the information in the card during the first visit. The patients were evaluated weekly and followed for total duration of four weeks. Pre versus post systolic and diastolic blood pressure were evaluated.

Result:

In 46 hypertensive patients, the average age was 57 years old, with 72% were females. 54% of patients had a normal Body Mass Index, and 28% were obese. Diabetes Mellitus presented as another comorbidity in 24% of patients, and only 4% of patients were active smokers. Pre-intervention systolic and diastolic blood pressure was 152 ± 12 mmHg and 90 ± 8 mmHg, respectively. Evaluation of post-intervention blood pressure outcomes revealed a significant reduction by 18 mmHg and 9 mmHg in systolic and diastolic blood pressure (p < 0,0001).

Conclusion:

In conclusion, Guideline-based educational card was an effective strategy in improving blood pressure control and may become a viable approach for other Primary Health Care.
3-10ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITORS (ARNI) POTENTIALS IN PATIENT WITH HEART FAILURE: A SYSTEMATIC REVIEW
Authors: Puratmaja Nalagafiar , Sjarfi Cheras Yezia Kharismia
Published: July 2020

Background:

Structural and/or functional cardiac abnormalities that lead to elevated intracardiac pressures with/without reduced output known as heart failure. Progressive establishment of the disease grows concomitantly with the number of cases despite the availability of various therapies. The recent standard recommends the substitution of angiotensin-converting-enzyme (ACE) inhibitors or angiotensin-II receptor blockers (ARBs) with angiotensin receptor blocker-neprilysin inhibitors (ARNI) in selected patients. The capacity of ARNI will be analyzed based on the latest clinical trials available.

Objective:

This study focus on revealing the clinical impact and potentials of ARNI in an attempt to counteract the decreasing capacity of the heart.

Method:

Literature finding involves four scientific databases, including PubMed, EbscoHost, ProQuest, and Cochrane. The primary search was concluded using certain Medical Subject Heading (MeSH) terms and filters. Two independent authors further analyzed selected interventional articles related to ARNI and heart failure. Relevance studies were reviewed using the Centre for Evidence-based Medicine (CEBM) critical appraisal tool to turn aside bias.

The result:

Data were collected from patients in three randomized controlled trials within five articles. Four of the reports investigate the use of ARNI compared to enalapril in acute decompensated heart failure (ADHF) and chronic heart failure (CHF). Another study compared ARNI to valsartan only therapy in heart failure patients with reduced ejection fraction (HFrEF). It shows that the use of ARNI contributes to a lower number of hospitalization cases and mortality rates while preventing further progression of heart failure.

Conclusion:

ARNI has adequate potential to prevent the progression of the disease while the encouragement of future investigation is essential.
4-1SEXUAL DYSFUNCTION IN WOMEN WITH HYPERTENSION: A CROSS-SECTIONAL STUDY
Authors: Magfira Nadya , Helda
Published: July 2020

Introduction:

Sexual dysfunction (SD) has been recently demonstrated as more frequent in women compared to men, and it is well known that hypertension is a significant risk for SD in male patients. However, data regarding SD in hypertensive women are far from conclusive.

Aim:

the study aimed to evaluate the relationship between SD and hypertension (HT) in women.

Methods:

A cross-sectional study was conducted in a private primary healthcare clinic in Serang Banten, Indonesia, from August to September 2019. The study involved all women aged 18 years or older, being married and sexually active in the past four weeks. Exclusion criteria were pregnant, had a history of pelvic surgery other than section Caesarea, and had a history of diabetes. Patient sexual function was assessed by Indonesian validated Female Sexual Function Index (FSFI-I). Patients were classified as SD if the total FSFI-I score was ≤ 26.55. The variables of the study were demographic and hypertension-related characteristics, depression, and obstetric history. One-way ANOVA and Multivariate logistic regression analysis were performed to evaluate the predictors of SD and calculate the Prevalence Odds Risk (POR) for SD in HT women.

Results:

Of a total of 442 women, 132 women had HT (29.86%, 88 treated, and 44 untreated). SD was found in 92% of hypertensive women compared with 73% of normotensive women (POR: 8.6, 95% Confidence Interval: 2.8–26.7). Furthermore, working women, overweight, and depression increased SD frequency. It was also determined that duration of hypertension is associated with declining of sexual function in women (p=0.03).

Conclusion:

This study showed that SD is more prevalent in hypertensive than in normotensive women. Patients and physicians need to deal with SD and should neither ignore nor superficially address this important issue.
4-6THE ASSOCIATION OF DNA METHYLATION OF A-ADDUCIN IN ESSENTIAL HYPERTENSION: A QUALITATIVE SYSTEMATIC REVIEW
Authors: Khairunnisa Hana , Ilman Atika B , Barry Fathul
Published: July 2020

Introduction:

Essential hypertension (EH) is one of the most common health problems with significant mortality and morbidity in the world. EH is a complex multifactorial disease resulting from both genetic and environmental factors. α-Adducin (ADD1) is one of several genetic markers that have been identified. DNA methylation is defined as the addition of a methyl group to the DNA molecule, which associated with a change in the activity of DNA segment without the affection of its sequence.

Method:

We comprehensively searched case-control studies about essential hypertension and α-adducin in electronic databases including PubMed, EMBASE, and JSTOR.

Results:

Those three studies (a total 1203 cases and 1148 controls) results were relatively similar, the ADD1 CpG2-5 methylation level was significantly associated with EH, lower CpG1 methylation level was associated with increased risk of EH in females while lower CpG2-5 methylation was associated with an increased risk of EH in males significantly.

Discussion:

EH is an age-related chronic condition affecting males more than females. We found that DNA methylation of ADD1 gene was significantly higher in females than in males. Adducin was implicated in the pathogenesis of EH by modulating Na+-K+-ATPase activity. CpG1 methylation can predict EH among females, and CpG2-5 methylation does among males.

Conclusion:

There was an association of DNA methylation of α-Adducin with essential hypertension.
4-7CORONARY ARTERY DISEASE ALTER ON NOVEL CLASSIFICATION LEFT VENTRICULAR GEMOMETRY IN HYPERTENSIVE PATIENTS IN HASAN SADIKIN GENERAL HOSPITAL BANDUNG
Authors: Tiksnadi B.B. , Martanto E. , Panggabean A. , Undarsa A.C. , Akbar M.R.
Published: July 2020

Background:

Coronary artery disease (CAD) was known to cause an increase in left ventricular mass and changes in cardiac dimensions in hypertensive patients. There is a novel classification of left ventricular (LV) geometry.

Objective:

To evaluate the impact of CAD on LV geometry (LV dilatation, hypertrophy, and concetricity) in hypertensive patients at the Hasan Sadikin General Hospital Bandung.

Method:

Between September and December 2019, 115 consecutive patients underwent trans-thoracal echocardiography examination in Hasan Sadikin General Hospital Bandung, who had suffered from hypertension. Hypertension was defined as resting systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg or on antihypertensive therapy routinely. CAD was defined as the patients have a known history of CAD in the medical record. Patients were divided based on LV dilation (end-diastolic volume[EDV]/body surface area[BSA]>75 ml/m2), LV hypertrophy (LVM/BSA>115 and >95 g/m2 on men and women respectively), and concentricity (RWT>0.42;0.32–0.42;or<0.32).

Results:

One-hundred-ten patients were included after excluding patients with incomplete data. Sixty patients (54.55%) were females, mean age was 56.95±11.54 years old. Forty patients was diagnosed CAD (36.36%), 70 patients non-CAD (63.63%). Dilation LV was found in 23 patients (20.9%); CAD vs non-CAD (15/40 (37,5%) vs 8/70 (11,8%)); p = 0,001. Hypertrophic LV was found in 70 patients (63.6%); CAD vs non-CAD (32/40 (80%) vs 38/70 (54.3%)); p = 0,008. Concentricity RWT > 0,42 (60%), RWT 0,32–0,42 (31.8%), RWT < 0,32 (8.2%). In CAD vs non-CAD (26/7/7 vs 40/28/2); p = 0,04.

Conclusion:

In hypertensive patients, CAD group has significant difference in LV dilatation, hypertrophy, and concentricity compared to it counterparts. Based on this novel classification, CAD in hypertensive patients might have an impact on its prognosis.
4-9FEATURES OF HOMOCYSTEINE LEVEL AND A POTENTIAL WAY OF IT'S CORRECTION IN HYPERTENSIVE PATIENTS
Authors: Vamsi Varahabhatla , Cherukuri Raja , Tekula Tejashwini , Ratnam Itham Venkat , Viktor Buriak , Vadym Vizir
Published: July 2020

Background:

Arterial hypertension (AH) is one of the most wide-spread cardiovascular pathology all over the world. Initiation and progression of AH are linked to many potentially modified metabolic factors, for example-hyperhomocysteinemia. Despite the fact that diagnostics, treatment and prevention of AH is evident, key risk factors correction are still concealed at present.

Aim:

To study the features of serum HH in hypertensive patients and optimize treatment strategy.

Methods:

According to the aim of our investigation, we examined 74 high cardiovascular risk level hypertensive patients (before and after 12-weeks of atorvastatin 20 mg per day oral administration based on their standard hypotensive treatment) and 68 healthy volunteers (equivalent with group of observation in age and gender representation) with fasting homocysteine plasma level via ELISA. The statistically significance was considered at P < 0,05.

Results:

It's set that AH is associated with fasting homocysteine plasma concentration 2,22 times more (P < 0,01) opposite to healthy subjects, that was according to mild level of hyperhomocysteinemia. Besides, it was found that additive 12-weeks treatment with atorvastatin (based on specific antihypertensive approaches) leads to clinically significant reduction of homocysteine plasma level by 28,78% (P < 0,05) in the hypertensive patients.

Conclusions:

HH is stationed as a key metabolic risk factor in way of arterial hypertension's formation and progression over the high cardiovascular risk population. At the same time, specific hypolipidemic and antiatherosclerotic treatment based on regular atorvastatin administration can be counted as an effective way of reducing elevated plasma homocysteine level and shows alternative pleiotropic effect of statins in AH patients.
Open Reduction Internal Fixation of Femoral Neck Fracture—Anterior Approach
Authors: Keshet Doron , Bernstein Mitchell
Published: July 2020

Femoral neck fractures are frequently treated with open reduction and internal fixation to achieve anatomical reduction. This video demonstrates open reduction internal fixation of a femoral neck fracture in a 59-year-old man, performed through an anterior approach. This approach provides safe and effective access to the femoral neck, including the subcapital and basicervical regions, with excellent direct visualization of the fracture site.
Minimally Invasive Plate Osteosynthesis Posterior Approach to Distal Humeral Shaft Fractures—A Surgical Technique
Authors: Krupko Thomas , Mayer Ryan , Scott Alesha , Aneja Arun , Moghadamian Eric
Published: July 2020

Comminuted extraarticular metaphyseal and diaphyseal fractures of the distal humerus frequently require operative fixation through a posterior approach. Most of the previously described approaches to the posterior humerus are dependent on large and extensile approaches. This video demonstrates open reduction and internal fixation of a comminuted metaphyseal distal humerus fracture through a minimally invasive posterior approach.
Prone Posteromedial Approach for Posterior Column Tibial Plateau Fractures
Authors: Foster Brock , Rodriguez-Buitrago Andres , Obremskey William T.
Published: July 2020

Tibial plateau fractures can involve fracture planes that require reduction and stabilization from a posterior approach. This includes posteromedial, posterolateral, and posterior column shear-type injuries. This video outlines the prone posteromedial approach to the tibial plateau for posterior column fracture exposure, reduction, and fixation.