bluuebunny/crossref_metadata_2025 huggingface dataset:
How (many) descriptive claims about political polarization exacerbate polarization
Authors: Peters Uwe
Published: February 2021

Recently, researchers and reporters have made a wide range of claims about the distribution, nature, and societal impact of political polarization. Here I offer reasons to believe that even when they are correct and prima facie merely descriptive, many of these claims have the highly negative side effect of increasing political polarization. This is because of the interplay of two factors that have so far been neglected in the work on political polarization, namely that (1) people tend to conform to descriptive norms (i.e., norms capturing [perceptions of] what others commonly do, think, or feel), and that (2) claims about political polarization often convey such norms. Many of these claims thus incline people to behave, cognize, and be affectively disposed in ways that contribute to social division. But there is a silver lining. People’s tendency to conform to descriptive norms also provides the basis for developing new, experimentally testable strategies for counteracting political polarization. I outline three.
Open access status of journals and articles in Journal Citation Reports
Authors: Kim Sang-Jun , Park Kay Sook
Published: February 2021

Purpose: There is somewhat of a difference between understanding the open access (OA) concept and practicing it by stakeholders. OA articles are mainly published by gold and hybrid OA journals, but the OA status may be confusing depending on the target databases. This study investigated the OA status of journals and articles and evaluated the extent to which OA2020 (publishing 90% of articles as OA) was achieved.Methods: This study collected OA data by combining 2014-2019 data from Journal Citation Reports at the journal level with Web of Science at the article level. Finally, 12,449 journals were analyzed focusing on gold and hybrid OA journals, and progress towards the goal of OA2020 was evaluated.Results: Even though 80.4% of Journal Citation Reports journals were gold and hybrid OA journals, only 20.9% of the articles were OA (gold OA journals, 16.6%; hybrid journals, 4.3%). The compound annual growth rate of the total articles was 4.7%, that of OA articles was 16.4%, and that of subscription articles was only 1.7%. Among the subscription journals, 77.4% had shifted to become hybrid journals, but only 5.2% of their articles were OA. Therefore, the hybrid journals were at the very early stage of OA publishing.Conclusion: Considerable progress must still be made to achieve the goal of OA2020. The influence of OA publishing will eventually expand and therefore, librarians should take interest in OA publishing for the library services.
Bibliometric analysis of journals, authors, and topics related to COVID-19 and Islamic finance listed in the Dimensions database by Biblioshiny
Authors: Rusydiana Aam Slamet
Published: February 2021

Purpose: This bibliometric study investigated the current state of documents on coronavirus disease 2019 (COVID-19) and Islamic finance published by digital object identifierequipped journals listed in the Dimensions database. The analysis focused on describing the characterictics and trends of the keywords, authors, and journals.Methods: The data analyzed were from 149 research publications in Dimensions. The search tems were “COVID” and “Islamic finance.” The searches used to establish the study dataset were last updated on August 27, 2020. Descriptive statistical methods were used, and a bibliometric analysis was conducted using Biblioshiny, an R-based app, to generate a bibliometric map.Results: The number of articles discussing the theme of COVID-19 and Islamic finance was quite large in recent months, with more than 100 articles published. The most popular keywords used were “COVID,” “food,” and “pandemic,” although there were also many keywords that related more specifically to the field of Islamic finance, namely “banks,” “markets,” “health,” “debt,” “equity,” “management,” and “stock.”Conclusion: This study provides an overview of trends in the most popular keywords, journals, and authors of articles on the topic of COVID-19 and Islamic finance, which has been quite a popular theme in recent months, thereby providing information for researchers specializing in the field of Islamic finance. This theme has the potential to continue to be developed.
Development of an open peer review system using blockchain and reviewer recommendation technologies
Authors: Choi Dong-Hoon , Seo Tae-Sul
Published: February 2021

In order to create a transparent and sound academic communication ecosystem centered on researchers, we developed a system that applied blockchain technology to an open peer review system. In this study, an open peer review system was developed based on Hyperledger Fabric, which is a private blockchain. The system can be operated in connection with the reviewer recommendation module of the existing submission management system. In the reviewer recommendation module, reviewers are recommended by excluding co-authors and colleagues after an expertise test. The blockchain system performs an open peer review process based on smart contracts, while the submission management system selects reviewers for peer review. A service broker intervenes between these two systems for data interchange. The system developed herein is expected to be used as a researcher-centered scholarly communication model in the open science era, in which the intervention of publishers is minimized, and authors and reviewers (as researchers) are centered.
Amor Imperuio (LC, I, 48): What Does It Mean?
Authors: Criado de Val Manuel
Published: February 2021

Not available.
«Mira a Bernardo»: alusión «sin sospecha»
Authors: Gerli Michael E.
Published: February 2021

No disponible.
Misoginy and Misprint in La Celestina, Act I
Authors: Bussell Thompson B.
Published: February 2021

Not available.
«Testigo es el cuchillo de tu abuelo» (Celestina I)
Authors: Bershas Henry N.
Published: February 2021

No disponible.
La Celestina on stage
Authors: Mandel Adrienne S.
Published: February 2021

No disponible.
Marcel Bataillon, (1895-1977)
Authors: Snow Joseph T.
Published: February 2021

No disponible.
La triple tentación de Melibea
Authors: Ayerbe-Chaux Reinaldo
Published: February 2021

No disponible.
La Tragicomedia de Calisto y Melibea de Juan de Sedeño: algunas observaciones a su primera escena, comparada con la original
Authors: Snow Joseph T.
Published: February 2021

No disponible.
«El plebérico coraçón»: Melibea's Heart?
Authors: Stamm James R.
Published: February 2021

No disponible.
Cota, His Imitator and La Celestina: The Evidence Re-Examined
Authors: Severin Dorothy S.
Published: February 2021

No disponible.
History and the Critical Enterprise, reseña de Peter Russell, Temas de la Celestina y otros estudios
Authors: Rank Jerry R.
Published: February 2021

N/A
«Amor imperuio» o «amor improuo» (LC I, 94)
Authors: Garci-Gómez Miguel
Published: February 2021

No disponible.
Mack Hendricks Singleton
Authors: Kasten Lloyd
Published: February 2021

N/A
Ponencias celestinescas
Authors: Snow Joseph T.
Published: February 2021

N/A
El 446º refrán de Celestina
Authors: Barrick Mac E.
Published: February 2021

No disponible.
Celestina's Hilado and Related Symbols
Authors: Costa Fontes Manuel da
Published: February 2021

No disponible.
La pícara Justina, ed. Bruno M. Damiani
Authors: Soons Alan
Published: February 2021

N/A
Preface
Authors: Severin Dorothy S.
Published: February 2021

N/A
Retos de un nuevo sistema de medición on-line
Authors: Bayo Caballero Eduardo
Published: February 2021

En medios nos gusta medir. Las diferentes métricas que envuelven la planificación de medios nos ayudan a estimar (primero) y a evaluar (después) el éxito o fracaso de la campaña en términos de alcance (cobertura), frecuencia media de contactos, afinidad, rentabilidad (c/GRP, CPM, CPC…), etc. El sector (agencias, anunciantes, soportes y entidades transversales como pueden ser la AIMC o la AEA) han consensuado y consolidado con su uso a lo largo de los años las variables y las fuentes con las que medimos la actividad publicitaria en medios tradicionales.
Feliz no día de la creatividad, la innovación, el diseño...
Authors: Sivera Sílvia
Published: February 2021

En un mundo de cuento podríamos celebrar la importancia de la creatividad, de la innovación o del diseño cada día del año. Todos nos sentiríamos como Alicia en su no cumpleaños y atravesaríamos espejos para saber qué pasa al otro lado. Pero en el mundo real, nos cuesta mirar por la ventana para saber qué pasa a nuestro lado. Y pasa que dedicamos días a reivindicar causas que deberíamos normalizar en nuestro día a día… para transformarlo.
MoJoBCN: hemos venido para quedarnos
Authors: Ollé Candela
Published: February 2021

El periodismo móvil o MoJo ya forma parte de muchas redacciones de España. Los periodistas usan el teléfono inteligente para organizar los equipos de trabajo, hacer directos, contar relatos a partir de una pequeña historia, llegar allí donde la cámara tradicional no puede o para narrar vía redes sociales. La evolución del periodismo en la era digital no tiene pausa, y como escuchamos en el MoJoBCN, hay que seguir haciendo periodismo de calidad —aunque con el móvil parezca que cualquier improvisación sea válida—. Nos encontramos ante desafíos constantes, pero afortunadamente los académicos ya han empezado a investigar y las universidades a ofrecer formación para los graduados y profesionales.
Shhhhhhhh...
Authors: Creus Amalia
Published: February 2021

Uno de los recuerdos más peculiares que guardo de mi primer viaje a Berlín fue la visita a la Habitación del Silencio (Raum der Stille). Esta pequeña habitación escondida en uno de los laterales de la puerta de Brandenburgo ofrece a cualquier persona que logre encontrarla un oasis de silencio y tranquilidad en pleno corazón de la capital alemana. Recuerdo esa experiencia como una mezcla de desconcierto y fascinación. Desconcierto por la falta de familiaridad con algo tan sencillo como el hecho de permanecer sentada, inmóvil, sola y en silencio en un lugar desconocido. Fascinación por el contraste con el bullicio exterior, y por lo intenso que me pareció —y me sigue pareciendo— ese inesperado instante de tranquilidad.
Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses
Authors: Maximova Olga A , Sturdevant Daniel E , Kash John C , Kanakabandi Kishore , Xiao Yongli , Minai Mahnaz , Moore Ian N , Taubenberger Jeff , Martens Craig , Cohen Jeffrey I , Pletnev Alexander G
Published: February 2021

Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of the immune and nervous system processes in a nonhuman primate model of West Nile virus neurological disease, we show that virus infection disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with distinct functions in each component of the axis. This pleiotropic gene regulation suggests an unintended off-target negative impact of virus-induced host immune responses on the neurotransmission, which may be a common feature of various viral infections of the CNS.
Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs
Authors: Liu Qiuying , Chen Xiaoli , Novak Mariah K , Zhang Shaojie , Hu Wenqian
Published: February 2021

The regulation of stem cell fate is poorly understood. Genetic studies in Caenorhabditis elegans lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA controls the pluripotency and differentiation of stem cells. Although let-7-microRNA-mediated inhibition of Trim71 promotes differentiation, whether and how Trim71 regulates pluripotency and inhibits the let-7 microRNA are still unknown. Here, we show that Trim71 represses Ago2 mRNA translation in mouse embryonic stem cells. Blocking this repression leads to a specific post-transcriptional increase of mature let-7 microRNAs, resulting in let-7-dependent stemness defects and accelerated differentiation in the stem cells. These results not only support the Trim71-let-7-microRNA bi-stable switch model in controlling stem cell fate, but also reveal that repressing the conserved pro-differentiation let-7 microRNAs at the mature microRNA level by Ago2 availability is critical to maintaining pluripotency.
Update Research of Virtual Reality Technology on Children with Autism
Authors: Liu Juan , Yang Zhaoyu , Jiao Wenyan , Liu Yonglin , Meng Xuchun , Wang Dan , Han Wenlu , Jiao Fuyong
Published: February 2021

Autism, is a neurodevelopmental disorder characterized by communication, communication disorder, narrow interest and stereotyped behavior. Existing studies have shown that VR (Virtual Reality) technology may have some unique advantages in interfering with children with autism. VR technology refers to the construction of an artificial, realistic, and multi-sensory virtual world through computers and other devices. In the aspect of auxiliary diagnosis, VR technology provides a unified observation standard through the manual foot movement and eye movement data of children in the virtual environment. At the same time, it can reflect the clinical characteristics of children according to the performance and response of children to complete tasks in virtual environment, and VR technology will be presented to children in the same environment as usual, which can better reflect the performance of children and adolescents in the real-life environment. In this paper, the application of VR technology in auxiliary diagnosis and rehabilitation training of children with autism is briefly reviewed to provide new ideas for clinical rehabilitation treatment of children with autism.
The role of biotechnology in the transition from plastics to bioplastics: an opportunity to reconnect global growth with sustainability
Authors: Degli Esposti Micaela , Morselli Davide , Fava Fabio , Bertin Lorenzo , Cavani Fabrizio , Viaggi Davide , Fabbri Paola
Published: February 2021

Building new value chains, through the valorization of biomass components for the development of innovative bio‐based products (BBPs) aimed at specific market sectors, will accelerate the transition from traditional production technologies to the concept of biorefineries. Recent studies aimed at mapping the most relevant innovations undergoing in the field of BBPs (Fabbri et al. 2019, Final Report of the Task 3 BIOSPRI Tender Study on Support to R&I Policy in the Area of Bio‐based Products and Services, delivered to the European Commission (DG RTD)), clearly showed the dominant position played by the plastics sector, in which new materials and innovative technical solutions based on renewable resources, concretely contribute to the achievement of relevant global sustainability goals. New sustainable solutions for the plastic sector, either bio‐based or bio‐based and biodegradable, have been intensely investigated in recent years. The global bioplastics and biopolymers market size is expected to grow from USD 10.5 billion in 2020 to USD 27.9 billion by 2025 (Markets and Markets, 2020, Bioplastics & Biopolymers Market by Type (Non‐Biodegradable/Bio‐Based, Biodegradable), End‐Use Industry (Packaging, Consumer Goods, Automotive & Transportation, Textiles, Agriculture & Horticulture), Region ‐ Global Forecast to 2025), and this high growth is driven primarily by the growth of the global packaging end‐use industry. Such relevant opportunities are the outcomes of intensive scientific and technological research devoted to the development of new materials with selected technical features, which can represent feasible substitutes for the fossil‐based plastic materials currently used in the packaging sectors and other main fields. This article offers a map of the latest developments connected to the plastic sector, achieved through the application of biotechnological routes for the preparation of completely new polymeric structures, or drop‐in substitutes derived from renewable resources, and it describes the specific role played by biotechnology in promoting and making this transition faster.
Rhodium Catalyzed Regioselective C−H Allylation of Simple Arenes via C−C Bond Activation of Gem‐difluorinated Cyclopropanes
Authors: Jiang Zhong‐Tao , Huang Jiangkun , Zeng Yaxin , Hu Fangdong , Xia Ying
Published: February 2021

Herein, we report a rhodium catalyzed directing‐group free regioselective C−H allylation of simple arenes. Readily available gem‐difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C−C and C−F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodology enables facile late‐stage functionalization of complex bioactive molecules. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram‐scale experiments. Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio‐enriched gem‐difluorinated cyclopropanes.
Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells
Authors: Bolitho Elizabeth M. , Coverdale James P. C. , Bridgewater Hannah E. , Clarkson Guy J. , Quinn Paul D. , Sanchez‐Cano Carlos , Sadler Peter J.
Published: February 2021

Most metallodrugs are prodrugs that can undergo ligand exchange and redox reactions in biological media. Here we have investigated the cellular stability of the anticancer complex [OsII[(η6‐p‐cymene)(RR/SS‐MePh‐DPEN)] [1] (MePh‐DPEN=tosyl‐diphenylethylenediamine) which catalyses the enantioselective reduction of pyruvate to lactate in cells. The introduction of a bromide tag at an unreactive site on a phenyl substituent of Ph‐DPEN allowed us to probe the fate of this ligand and Os in human cancer cells by a combination of X‐ray fluorescence (XRF) elemental mapping and inductively coupled plasma‐mass spectrometry (ICP‐MS). The BrPh‐DPEN ligand is readily displaced by reaction with endogenous thiols and translocated to the nucleus, whereas the Os fragment is exported from the cells. These data explain why the efficiency of catalysis is low, and suggests that it could be optimised by developing thiol resistant analogues. Moreover, this work also provides a new way for the delivery of ligands which are inactive when administered on their own.
Host–Guest Interaction Modulation in Porous Coordination Polymers for Inverse Selective CO2/C2H2Separation
Authors: Gu Yifan , Zheng Jia‐Jia , Otake Ken‐ichi , Shivanna Mohana , Sakaki Shigeyoshi , Yoshino Haruka , Ohba Masaaki , Kawaguchi Shogo , Wang Ying , Li Fengting , Kitagawa Susumu
Published: February 2021

Controlling gas sorption by simple pore modification is important in molecular recognition and industrial separation processes. In particular, it is challenging to realize the inverse selectivity, which reduces the adsorption of a high‐affinity gas and increases the adsorption of a low‐affinity gas. Herein, an “opposite action” strategy is demonstrated for boosting CO2/C2H2selectivity in porous coordination polymers (PCPs). A precise steric design of channel pores using an amino group as an additional interacting site enabled the synergetic increase in CO2adsorption while suppressing the C2H2adsorption. Based on this strategy, two new ultramicroporous PCP physisorbents that are isostructural were synthesised. They exhibited the highest CO2uptake and CO2/C2H2volume uptake ratio at 298 K. Origin of this specific selectivity was verified by detailed density functional theory calculations. The breakthrough separation performances with remarkable stability and recyclability of both the PCPs render them relevant materials for C2H2purification from CO2/C2H2mixtures.
p‐Type Charge Transfer Doping of Graphene Oxide with (NiCo)1−yFeyOx for Air‐Stable, All‐Inorganic CsPbIBr2 Perovskite Solar Cells
Authors: Du Jian , Duan Jialong , Yang Xiya , Duan Yanyan , Zhou Quanzhu , Tang Qunwei
Published: February 2021

The precise regulation of interfacial charge distribution highly determines the power conversion efficiency of perovskite solar cells (PSCs). Herein, inorganic (NiCo)1−yFeyOx nanoparticle decorated graphene oxide (GO) is successfully demonstrated as a hole booster for all‐inorganic CsPbIBr2 PSC free of precious metal electrode. Arising from the spontaneous electron transfer induced p‐type doping of GO from edged oxygen‐containing functional groups to (NiCo)1−yFeyOx, the best all‐inorganic CsPbIBr2 PSC achieves an efficiency of 10.95 % under one standard sun owing to the eliminated paradox between charge extraction and charge localization in GO surface. Furthermore, the champion device exhibits an excellent long‐term stability at 10 % relative humidity without encapsulation over 70 days because of the suppressed ions migration.
Pressure‐Responsive Two‐Dimensional Metal–Organic Framework Composite Membranes for CO2 Separation
Authors: Ying Yunpan , Zhang Zhengqing , Peh Shing Bo , Karmakar Avishek , Cheng Youdong , Zhang Jian , Xi Lifei , Boothroyd Chris , Lam Yeng Ming , Zhong Chongli , Zhao Dan
Published: February 2021

The regulation of permeance and selectivity in membrane systems may allow effective relief of conventional energy‐intensive separations. Here, pressure‐responsive ultrathin membranes (≈100 nm) fabricated by compositing flexible two‐dimensional metal–organic framework nanosheets (MONs) with graphene oxide nanosheets for CO2 separation are reported. By controlling the gas permeation direction to leverage the pressure‐responsive phase transition of the MONs, CO2‐induced gate opening and closing behaviors are observed in the resultant membranes, which are accompanied with the sharp increase of CO2 permeance (from 173.8 to 1144 gas permeation units) as well as CO2/N2 and CO2/CH4 selectivities (from 4.1 to 22.8 and from 4 to 19.6, respectively). The flexible behaviors and separation mechanism are further elucidated by molecular dynamics simulations. This work establishes the relevance of structural transformation‐based framework dynamics chemistry in smart membrane systems.
Isotopic Labelling of Confined Carbyne
Authors: Cui Weili , Shi Lei , Cao Kecheng , Kaiser Ute , Saito Takeshi , Ayala Paola , Pichler Thomas
Published: February 2021

Carbyne is a one‐dimensional allotrope of carbon consisting of a linear chain of carbon atoms bonded to each other with exceptional strength. Its outstanding mechanical, optical, and electronic properties have been theoretically predicted, but its stability has only been achieved when grown encapsulated in the hollow core of carbon nanotubes. One of the advantages of this confinement is that its properties can be controlled by the chain's length and surrounding environment. We investigated an alternative way of gaining control of its properties is using isotope labelling as tuning mechanism. The optimized liquid precursor was first chosen among several options, which can greatly enhance the yield of the confined carbyne. Then isotopic labelled liquid precursor was encapsulated for further synthesis of isotopic labelled confined carbyne. This allowed us to obtain pioneering results on isotope engineered carbyne with around 11.9 % of 13C‐labelling using 13C‐methanol as precursor.
Proton Capture Strategy for Enhancing Electrochemical CO2 Reduction on Atomically Dispersed Metal–Nitrogen Active Sites**
Authors: Wang Xinyue , Sang Xiahan , Dong Chung‐Li , Yao Siyu , Shuai Ling , Lu Jianguo , Yang Bin , Li Zhongjian , Lei Lecheng , Qiu Ming , Dai Liming , Hou Yang
Published: February 2021

Electrocatalysts play a key role in accelerating the sluggish electrochemical CO2 reduction (ECR) involving multi‐electron and proton transfer. We now develop a proton capture strategy by accelerating the water dissociation reaction catalyzed by transition‐metal nanoparticles (NPs) adjacent to atomically dispersed and nitrogen‐coordinated single nickel (Ni−Nx) active sites to accelerate proton transfer to the latter for boosting the intermediate protonation step, and thus the whole ECR process. Aberration‐corrected scanning transmission electron microscopy, X‐ray absorption spectroscopy, and calculations reveal that the Ni NPs accelerate the adsorbed H (Had) generation and transfer to the adjacent Ni−Nx sites for boosting the intermediate protonation and the overall ECR processes. This proton capture strategy is universal to design and prepare for various high‐performance catalysts for diverse electrochemical reactions even beyond ECR.
Development of Generic G Protein Peptidomimetics Able to Stabilize Active State Gs Protein‐Coupled Receptors for Application in Drug Discovery
Authors: Mannes Morgane , Martin Charlotte , Triest Sarah , Pia Dimmito Marilisa , Mollica Adriano , Laeremans Toon , Menet Christel J. , Ballet Steven
Published: February 2021

G protein‐coupled receptors (GPCRs) represent an important group of membrane proteins that play a central role in modern medicine. Unfortunately, conformational promiscuity hampers full therapeutic exploitation of GPCRs, since the largest population of the receptor will adopt a basal conformation, which subsequently challenges screens for agonist drug discovery programs. Herein, we describe a set of peptidomimetics able to mimic the ability of G proteins in stabilizing the active state of the β2 adrenergic receptor (β2AR) and the dopamine 1 receptor (D1R). During fragment‐based screening efforts, these (un)constrained peptide analogues of the α5 helix in Gs proteins, were able to identify agonism pre‐imprinted fragments for the examined GPCRs, and as such, they behave as a generic tool, enabling an engagement in agonist earmarked discovery programs.
A High‐Resolution View of the Coordination Environment in a Paramagnetic Metalloprotein from its Magnetic Properties
Authors: Ravera Enrico , Gigli Lucia , Suturina Elizaveta A. , Calderone Vito , Fragai Marco , Parigi Giacomo , Luchinat Claudio
Published: February 2021

Metalloproteins constitute a significant fraction of the proteome of all organisms and their characterization is critical for both basic sciences and biomedical applications. A large portion of metalloproteins bind paramagnetic metal ions, and paramagnetic NMR spectroscopy has been widely used in their structural characterization. However, the signals of nuclei in the immediate vicinity of the metal center are often broadened beyond detection. In this work, we show that it is possible to determine the coordination environment of the paramagnetic metal in the protein at a resolution inaccessible to other techniques. Taking the structure of a diamagnetic analogue as a starting point, a geometry optimization is carried out by fitting the pseudocontact shifts obtained from first principles quantum chemical calculations to the experimental ones.
Construction of Covalent Organic Frameworks with Crown Ether Struts
Authors: An Shuhao , Xu Qing , Ni Zhihui , Hu Jun , Peng Changjun , Zhai Lipeng , Guo Yu , Liu Honglai
Published: February 2021

Crown ethers are a class of macrocyclic molecules with unique flexible structures but they are rarely integrated in covalent organic frameworks (COFs). To date, employing flexible organic units such as crown ethers to construct COFs with high crystallinity and surface area are still a challenge. In this work, two new COFs with different flexible crown ethers as backbone rather than side chains are synthesized and further employed for alkali metal ions separation. Both of COFs possess high surface areas, good crystallinity, and excellent chemical stability. Interestingly, these two new COFs with 18‐crown‐6 or 24‐crown‐8 units showed remarkable binding ability of K+ or Cs+ owing to the size‐fit effect. This work demonstrated that the unique structural features of crown ethers will lead to increase interest in fabricating COFs with crown ethers.
A Balance Between Capture and Release: How Nanochaperones Regulate Refolding of Thermally Denatured Proteins
Authors: Ma Feihe , Wu Xiaohui , Li Ang , Xu Linlin , An Yingli , Shi Linqi
Published: February 2021

Nanochaperones have been designed and used for regulating the (re)folding of proteins, treating protein misfolding‐related diseases, and, more recently, in drug delivery. Despite various successes, a complete understanding of the working mechanisms remains elusive, which represents a challenge for the realization of their full potential. Here, we thoroughly investigated the functioning of differently charged nanochaperones that regulate the refolding of thermally denatured lysozyme. We found that the balance between the capture and release of lysozyme clients that are controlled by nanochaperones plays a key role in regulating refolding. More importantly, the findings could be applied to other enzymes with various physicochemical properties. On the basis of these results, we could recover the activity of enzymes with high efficiency either after 20 days of storage at 40 °C or heating at high temperatures for 30–60 min. Our results provide important new design strategies for nanochaperone systems to improve their properties and expand their applications.
A Self‐Catabolic Multifunctional DNAzyme Nanosponge for Programmable Drug Delivery and Efficient Gene Silencing
Authors: Wang Jing , Yu Shanshan , Wu Qiong , Gong Xue , He Shizhen , Shang Jinhua , Liu Xiaoqing , Wang Fuan
Published: February 2021

DNAzyme‐based gene therapy holds immense prospects for effectively treating severe diseases, yet is constrained with inefficient delivery and unconditional activation. Herein, we designed a bioinspired self‐catabolic DNA nanocapsule for sustaining tumor‐specific cascade activation of therapeutic DNAzyme. The exquisite DNAzyme was temporarily masked by the self‐excising DNAzyme in the hierarchical rolling circle replication (RCR) nanostructures, thus stayed in an inactive state in physiological fluids. Through the multivalent tumor‐anchoring aptamer strands, the RCR nanocapsule was specifically accumulated in cancer cells and was sequentially activated for motivating the ultimate DNAzyme‐mediated gene silencing via the intelligent stimuli‐responsive cascade DNAzyme activation. By virtue of the programmable RCR assembly strategy, our compact DNAzyme nanoplatform shows great promise for developing versatile smart gene therapeutics and personalized nanomedicines.
Towards High‐Performance Zinc‐Based Hybrid Supercapacitors via Macropores‐Based Charge Storage in Organic Electrolytes
Authors: Qiu Xuan , Wang Nan , Wang Zhuo , Wang Fei , Wang Yonggang
Published: February 2021

Zn‐based aqueous supercapacitors are attracting extensive attention. However, most of the reported long‐life and high‐power performances are achieved with low Zn‐utilization (<0.6 %) and low mass loading in cathode (<2 mg cm−2). And, many obtained high energy densities are generally evaluated without considering the mass of Zn‐anode. Herein, we propose a Zn‐based hybrid supercapacitor, involving a metal organic framework derived porous carbon cathode, a Zn‐anode and an N, N‐dimethylformamide (DMF)‐based electrolyte containing Zn2+. We demonstrate that the charge storage of cathode mainly occurs in macropores, showing high rate performance at high mass loading (40 mg cm−2). Furthermore, the aprotic nature of electrolyte and formation of Zn2+‐DMF complex avoid the Zn‐corrosion and dendrite formation. Therefore, the supercapacitor shows a long‐life (9,000 cycles) with a high Zn‐utilization (2.2 %). When calculated with the total mass of cathode (40 mg cm−2) and Zn‐anode, the energy density reaches 25.9 Wh kg−1.
A Cysteine‐Mediated Synthesis of Red Phosphorus Nanosheets
Authors: Mo Jianbin , Xu Yun , Zhu Longqian , Wei Wei , Zhao Jing
Published: February 2021

Among phosphorus‐based nanomaterials, layered black phosphorus and violet phosphorus have been actively explored in the past decade. However, methods for the synthesis of red phosphorus nanosheets (RPNSs) is lacking, even though red phosphorus (RP) is commercially available at low cost and has excellent chemical stability at room temperature. We report an efficient strategy for fabrication of RPNSs and doped RPNSs using cysteine as a reducing reagent. Data from in vitro and in vivo studies suggested that RPNSs can trigger production of reactive oxygen species, DNA damage, and subsequent autophagy‐mediated cell death in a shape‐dependent manner. Our findings provide a method for construction of layered RP nanomaterials and they present a unique mechanism for the application of phosphorus‐based materials in nanomedicines.
Influence of grape marc extract on tuning the intermolecular interactions in the high‐density polyethylene
Authors: Zujovic Zoran , Ray Sudip , Vandermeer Charlotte , Bowmaker Graham A. , Kilmartin Paul A.
Published: February 2021

Intermolecular interactions and molecular dynamics in thin films of high‐density polyethylene (HDPE) containing a high loading of Grape Marc Extract (GME) were analyzed by solid‐state NMR. Optical microscopy (OM), Scanning Electron Microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies were used to corroborate the findings. The OM and SEM images and 1H‐13C RAMP CP/MAS (ramped amplitude cross‐polarization/magic‐angle spinning) spectra of HDPE, HDPE‐GME, and GME confirmed the incorporation of the GME into the HDPE structure. The results were compared to those for an unfilled HDPE film. The influence of GME on enhancing the amorphous nature of HDPE, altering the crystalline melting behavior and possible intermolecular interactions were evident from the DSC and FTIR. The NMR spin‐diffusion and T1(1H), T2(1H), T1ρ*(13C), T1ρ(1H) relaxation and variable contact time experiments revealed the interactions and dynamics at the sub‐micron level.
Three endogenous cellulases from termite, Reticulitermes speratus KMT001
Authors: Ahn Hee‐Hoon , Kim Tae‐Jong
Published: February 2021

Among termites, lower termites need symbiotic microorganisms in the digestive tract for digestion and cellulose metabolism. In this symbiotic relationship, the decomposition of cellulose is initiated by endoglucanase in termite salivary glands and completed by β‐glycosidase of symbiotic microorganisms in the hindgut. The expression of β‐glycosidase in lower termites has been reported in recent studies. The expression of two endoglucanases and one β‐glycosidase gene related to cellulose degradation was identified in Reticulitermes speratus, a lower termite, through transcriptomic analysis. The proposed enzyme activities of three identified cellulose degradation genes were confirmed by heterologous expression in Escherichia coli. In addition to the endoglucanase expressed in the salivary gland, additional endoglucanase and β‐glycosidase genes suggest that R. speratus performs the overall cellulose digestion using its own enzymes at all stages.
Evaluation of Through‐Space Electronic Coupling in the Cofacially Aligned π‐Stacked Organic Mixed‐Valence System
Authors: Im Eun Ji , Jung Hae Won , Kang Youn K.
Published: February 2021

A new π‐stacked compound, 1,8‐bis(2′,5′‐dimethoxy‐4′‐methyl‐[1,1′‐biphenyl]‐4‐yl)naphthalene (1) has been synthesized and characterized as a precursor molecule of monocationic mixed‐valence system (MVS). Cyclic and differential pulse voltammograms reveal that the ΔE°ox value between two sequential oxidation potentials is 163 mV. The three‐dimensional geometries of 1, 1•+, and 12+ were obtained via using density functional theory (DFT) calculations with a range‐separated hybrid functional and dispersion corrections (LC‐wPBE‐D3). Two dimethoxytoluene redox centers were aligned in parallel with van der Waals interplanar distances (3.50–3.70 Å). The electronic coupling in this MVS was evaluated by two different approaches: (1) Mulliken–Hush analysis of intervalence charge transfer (IVCT) band obtained from the spectroelectrochemical method, and (2) partial charge distribution analysis of quinonoidal distortion of D•+/D centers obtained from theoretical DFT calculations. The H12 were 2055 and 1903 cm−1 by (1) and (2), respectively. This work suggests that the pure through‐space electronic coupling can be large when two aromatic redox centers are properly aligned.
F‐wave parameters and body mass index in carpal tunnel syndrome
Authors: Adebayo Philip B. , Mwakabatika Rose E.
Published: February 2021

Background

Severe carpal tunnel syndrome (CTS) readily lends itself to both clinical and electrophysiological recognition. The uncertainty sometimes is in identifying and quantifying motor involvement in mild and, perhaps, in moderate CTS. Our study aimed to evaluate F responses in mild and moderate CTS and determine the contribution of BMI to the F‐wave parameters.

Methods

A retrospective review of the clinical and electrophysiological data of patients with CTS seen at the clinical neurophysiology laboratory of Aga Khan Hospital, Dar es Salaam, between 1 August 2017 and 31 July 2019 was retrieved. Carpal tunnel syndrome was graded according to the electrophysiological criteria of Padua. The F‐wave parameters of patients with mild‐to‐moderate CTS were analyzed and compared with asymptomatic controls.

Result

We studied 91 hands. Twenty‐two hands were asymptomatic controls, 30 hands had mild CTS, and 39 hands had moderate CTS. Patients with moderate CTS were more obese (p =.011), had more females (p =.044), and were older (p= <0.001). F‐wave parameters were not convincingly different between mild and moderate CTS. F‐wave chronodispersion (p =.035) and F‐wave persistence (0.019) were significantly different between nonobese control and mild and moderate CTS. Median–ulnar F‐wave latency difference (FWLD) was significant between obese patients with mild CTS and moderate CTS scores (p =.017).

Conclusion

Although a clear difference exists between F‐wave parameters in asymptomatic controls and those with CTS, the F‐wave study is inadequate in distinguishing mild and moderate CTS even in the context of BMI. Median–ulnar F‐wave latency difference (FWLD) appeared to be a promising discriminant parameter between obese patients with mild CTS and those with moderate CTS.
Change of right ventricular systolic pressure can indicate dasatinib‐induced pulmonary arterial hypertension in chronic myeloid leukemia
Authors: Lee Sung‐Eun , Hyun Kong Jee , Kim Soo‐Hyun , Jang Eun‐Jung , Chung Nack‐Gyun , Cho Bin , Joong Oh Suk , Jung Hae‐Eok , Youn Ho‐Joong , Chung Woo‐Baek , Kim Dong‐Wook
Published: February 2021

Background

We investigated the feasibility of the clinical application of non‐invasive transthoracic echocardiography for diagnosis of pulmonary arterial hypertension induced by dasatinib (D‐PAH) in chronic myeloid leukemia (CML).

Methods

A total of 451 CML patients who were examined by 2D‐echocardiography at least once at baseline and/or during dasatinib therapy as frontline (n = 196) and subsequent line (n = 255) therapies were included in this study. D‐PAH was defined as right ventricular systolic pressure (RVSP) >40 mm Hg with relevant symptoms and the absence of other specific etiologies.

Results

A total of 847 echocardiographies were performed including at baseline (n = 255) and during dasatinib treatment (n = 592). During the median of 36.2 (0.1–181.8) months of dasatinib therapy, the level of RVSP gradually increased (Spearman's r = 0.2819, p < 0.001) and the mean RVSP was significantly increased after taking dasatinib therapy compared with baseline. During dasatinib therapy, 56 (12.4%) patients had RVSP >40 mm Hg without (asymptomatic, n = 27, 48.2%) or with symptoms (D‐PAH, n = 29, 51.8%). All asymptomatic patients maintained dasatinib therapy without further symptoms and the D‐PAH patients ultimately switched to other tyrosine kinase inhibitors. After dasatinib discontinuation, 13 (45%) and 15 (52%) patients showed RVSP normalization and gradual decrease, respectively.

Conclusions

Our large cohort study demonstrated that the gradual increment of RVSP might be induced by dasatinib and non‐invasive echocardiography can be fast way for early diagnosis as well as for monitoring of D‐PAH.
Mapping the influence of country‐of‐origin knowledge, consumer ethnocentrism, and perceived risk on consumer action against foreign products
Authors: Ortega‐Egea José Manuel , García‐de‐Frutos Nieves
Published: February 2021

Consumers in Western markets are often called against foreign‐made products and their country‐of‐origin (COO), particularly against controversial COOs and products. As a result, Asian emerging countries and their manufacturing industries (e.g., apparel, toys, or chemicals) have become major targets of anti‐consumption in the West, with criticism rooted in political‐economic, social, and/or environmental issues. In addition, Western consumers' ethnocentric tendencies are often reinforced by campaigning for domestic product/service alternatives. This backdrop raises questions about the degree of consumers' macro COO knowledge and ethnocentrism, and of their importance as levers of consumer concern about (i.e., risk perceptions) and anti‐consumption of foreign products from a controversial COO. This article thus sheds light on the extent to which COO knowledge (whether macro or based on usage experience), along with consumer ethnocentrism, can be considered antecedents of two risk perception types and, in turn, of country‐driven anti‐consumption (CDAC)—in the context of this work, Spanish consumers' reluctance to buy and (non‐)ownership of Chinese apparel products. The findings reveal that consumer ethnocentrism heightens both psycho‐social and performance risk perceptions and contributes to reluctance to buy. Macro COO knowledge affects CDAC only indirectly through performance risk perceptions. By contrast, usage experience attenuates both performance and psycho‐social risk perceptions and directly affects foreign product ownership. Risk perceptions predict and mediate most of the effects of COO knowledge, consumer ethnocentrism, and usage experience on CDAC outcomes. Implications for research, policy, and practice are also discussed.
Customers' social interactions and panic buying behavior: Insights from social media practices
Authors: Naeem Muhammad , Ozuem Wilson
Published: February 2021

The Covid‐19 pandemic led to social distancing and lockdown practices, which increased social interactions and information exchange on social media for timely decision making. This study explores how social practices and social influence generated through social media created panic buying behavior among customers. A social constructionist epistemological position was taken in order to understand the social practice of information sharing and to ask why different meanings were ascribed to Covid‐19 pandemic. Qualitative data collection and analysis methods were used to understand these subjective realities. A total of 40 UK customers participated in semi‐structured interviews in which they were asked about their usage of social media during the pandemic. Results revealed that social media increased the sharing of viral video evidence, such as empty shelves and quarreling in grocery stores, which increased fear and uncertainty; as a result, people shared recommendations to stay at home and buy extra for survival. Analysis revealed that social media increased awareness of stock unavailability in other parts of world, such as the USA, China, and Germany; therefore, people took proactive actions, such as stockpiling or panic buying, to avoid risks and uncertainties. The major theoretical contribution of this study is that the researcher merged social practice theory and social influence theory, and constructed a research framework which provides understanding of the social factors generated through social media platforms that increased socially influenced panic buying practices among UK customers. This study suggests that there is a need to control socially shared information and panic buying behavior and how socially shared information can influence different people in different contexts.
Increasing stroke events in patients with ST elevation myocardial infraction and cardiogenic shock: A cause for concern
Authors: Kayani Waleed T. , Jneid Hani
Published: February 2021

Key Points

The incidence of stroke in patients with STEMI complicated by cardiogenic shock (CS) is much higher than in those without CS. Use of percutaneous Mechanical Circulatory Support (MCS) is associated with a higher incidence of stroke in these patients; however, a causal relationship cannot be inferred.

Careful attention should be given to stroke mitigation and management strategies in this cohort and judicious use of MCS is warranted.

Future prospective clinical studies are needed to examine the impact of MCS on stroke incidence in these patients and further validate these clinically important findings.
Negative impact of coronavirus on interventional cardiology fellows' training: Let's limit collateral damage of the pandemic
Authors: Tarantini Giuseppe , Nai Fovino Luca
Published: February 2021

Key Points

Coronavirus disease pandemic has caused a dramatic reduction of elective and urgent interventional cardiology procedures, with a negative impact on training of interventional cardiology fellows.

This study showed that 95% of interventional cardiology fellows during the first wave of the COVID‐19 pandemic believe that their training would be moderately or severely impacted by the health crisis.

Interventional cardiology programs need to reorganize in order to ensure safe pathways for both urgent and elective cases, primarily for patients' care but also to grant an adequate caseload for trainees.
Hemodynamic compromise in pulmonary embolism: “A tale of two ventricles”
Authors: Bowers Terry , Goldstein James A.
Published: February 2021

Key Points

In acute pulmonary embolism (PE), low cardiac output (CO)–hypotension results from disparate ventricular conditions: The left ventricle (LV) is under‐filled and contracting vigorously, whereas the right ventricle (RV) is failing and dilated.

The proximate cause of LV preload deprivation is thrombus‐induced pulmonary vascular obstruction; abruptly increased pulmonary vascular resistance (PVR) induces acute RV systolic dysfunction which further compromises trans‐pulmonary flow.

“Escalation of Care” interventions (thrombolytics and aspiration thrombectomy) improve systemic hemodynamics by increasing LV preload delivery directly by reducing PVR and indirectly by relief of the strained failing RV.
Case of rupture ectopic pregnancy with emergency contraception levonorgestrel 0.075 mg in a lactating woman
Authors: Masud Nazish , AlShaibi Saleh , AlBassri Tala , Khan Saad , Khan Fahad
Published: February 2021

Levonorgestrel emergency contraception (LNG‐EC) tends to make uterus unfavorable for implantation but does not prevent embryo implantation. Emergency contraceptives pills should be used with caution among lactating women who at the same time should be monitored closely for ectopic pregnancy.
A community pharmacist's intervention in antipsychotic drug‐induced sexual dysfunction in a patient with schizophrenia
Authors: Maehara Masaki , Sugiyama Masayasu
Published: February 2021

The community pharmacist interviewed a patient with sexual dysfunction (SD) and suggested a change in prescription. Early intervention by the community pharmacist ameliorated antipsychotic drug‐induced SD timeously.
Mycobacterium infection as a mimicker of brain metastasis
Authors: de Oliveira Wertheimer Guilherme Soares , Rossi Assis‐Mendonça Guilherme , de Souza Queiroz Luciano , Reis Fabiano
Published: February 2021

Mycobacterium infection is a differential diagnosis to be considered in brain multifocal lesions with peripheral enhancement.
Pierpont syndrome‐Report of a new patient
Authors: Ismaili–Jaha Vlora , Spahiu‐Konusha Shqipe , Jaha Art
Published: February 2021

We report on a 6‐year‐old girl with Pierpont Syndrome who was diagnosed using the whole‐exome sequencing technique. In addition to commonly recognized traits, our patient had scoliosis, a feature reported only in one other occasion.