bluuebunny/crossref_metadata_2025 huggingface dataset:
T2 relaxation times of the thoracic intervertebral discs in children 8 to 10 years old.
Authors: Shcherbakova Yulia , van der Velden Tijl , Lafranca Peter , Castelein Rene , Schlosser Tom , Ito Keita , Seevinck Peter
Published: November 2024

Motivation: T2 relaxation time is a promising biomarker for the hydration and maturation state of the IVD in children, however, very little is known about it. Goal(s): The goal is to provide the baseline for T2 relaxation times in thoracic IVDs in children. Approach: T2 relaxometry performed in thoracic IVDs of 10 children. Results: In children: highest T2 values are in the core of Nucleus Pulposus (200-270 ms), T2 values in the Nucleus Pulposus - Annulus Fibrosus transition zone (110-130 ms) are more similar to those in adult NP tissue. This result is consistent with higher water content expected in pediatric vs. adult NP tissue. Impact: T2 values of healthy subjects can be used for the assessment of IVDs in children, opening new avenues to monitor developmental spine disease, research lower back pain as well as potential treatments.
Investigating the relationship between diffusion MR measures and passive torques of finger flexor muscles in individuals with cerebral palsy
Authors: Joshi Divya , Sajjadi Afsheen , Dewald Julius , Acosta Ana Maria , Hruby Alexandra , Ingo Carson
Published: November 2024

Motivation: Individuals with cerebral palsy (CP) often experience atypical biomechanical properties in the hand, yet little is known regarding the in vivo microstructural mechanisms in the muscle that underlie these impairments. Goal(s): This study aimed to establish the relationship between diffusion MRI measures in forearm muscles and biomechanical features of the fingers. Approach: Diffusion MR and torque measurements were acquired in five individuals with CP. Correlations between MR measures and the passive torque at the finger joints were investigated. Results: Passive torque was significantly correlated with muscle volume (r=0.68,p=0.045) and FA (r=0.69,p=0.040), but FA and muscle volume were not significantly correlated with one another. Impact: Diffusion MR-derived metrics such as FA and muscle volume have potential to be clinically translatable measures for identifying altered biomechanics in individuals with cerebral palsy and other populations with neuromuscular pathologies.
Total tumor apparent diffusion coefficient histogram parameters identify ISS stages in multiple myeloma with diffuse infiltration
Authors: Li Jiao , Wang Qin , Zhou Junde , Liu Dong , Zhu Jinxia , Grimm Robert , Xue Huadan , Jin Zhengyu
Published: November 2024

Motivation: Is there any difference in the ttADC histogram parameters at different ISS stages in multiple myeloma patients with diffuse infiltration visually?Goal(s): The goal was to explore the difference in ttADC histogram parameters and clinical indicators in multiple myeloma patients with diffuse infiltration at different ISS stages. Approach: The ttADC histogram parameters were obtained by sketching the lesions of the whole body on WB-DWI images using MRTTL software. Results: Age, hemoglobin, creatinine, and ttADC_5% were different at different ISS stages. Impact: Diffuse infiltration is generally thought to be associated with a poorer prognosis for MM patients. Our study shows that although all patients have diffuse infiltration, different ttADC histogram parameters may result in different prognosis.
Utility of diffusion-weighted magnetic resonance imaging in predicting treatment response to radiotherapy in locally advanced cervical cancer
Authors: Liang Chunyu , Xu Zhiyuan , Shen Xinping
Published: November 2024

Motivation: Radiotherapy (RT) is regarded as standard therapy for locally advanced cervical cancer. To date there are no accepted modalities that can reliably predict treatment response. Goal(s): Present study aimed to explore the baseline and interim-ADC as well as change in ADC for predicting treatment outcomes. Approach: 80 patients underwent pelvis MRI at least three times: before treatment, juring the course of RT and after completion of RT. Following values were calculated: Pre-ADC , Interim-ADC, △ADC and △%ADC. Treatment outcome was assessed by RECIST. Results: Pre-treatment tumor size and interim-ADC could be potential biomarkers for predicting treatment outcomes in cervical cancer patients referred for RT. Impact: The results of present study can evaluate the early efficacy of RT, in order to allow for the timely adjustment of treatment plans, improve the efficacy and prognosis, and provide a reference for the clinical individualized treatment of cervical cancer.
Differentiation of benign and malignant breast lesions using DWI with a fractional-order calculus(FROC) model based on SMS technique
Authors: Wang Fei , Sun Yinan , Yang Qin , Zhang Baoti , Liu Mengxiao , Zhu Juan
Published: November 2024

Motivation: This study focus on improving imaging time and image quality while accurately distinguishing between benign and malignant breast lesions. Goal(s): To assess the diagnostic capabilities of the FROC diffusion model combined with SMS technology for breast lesions. Approach: Compare two diffusion model, the traditional single-index DWI model and the FROC, and then evaluate their diagnostic performance, image quality, and the consistency of results using SMS technology. Results: FROC combined with SMS offered a feasible and effective approach for distinguishing benign and malignant breast lesions, while the diagnostic performance of D and β values from FROC was potentially superior to the traditional ADC values. Impact: The research introduces an innovative approach that combines the FROC-DWI model with SMS technology to enhance the efficiency and diagnostic capabilities of breast imaging, potentially improving patient outcomes and reducing unnecessary invasive procedures.
Virtual gadolinium contrast enhancement MRI using deep learning GAN in rectal cancer: a proof-of-concept two-center study
Authors: Gao Xinyi , Ma Dening
Published: November 2024

Motivation: It would be clinically beneficial if GBCAs enhancement could be accurately synthesized without any GBCAs administration though AI. Goal(s): To evaluate the feasibility of deep learning in synthesizing VTE based on noncontrast rectal cancer MRIs obtained without the use of gadolinium. Approach: Deep learning networks were trained and validated on nonenhanced conventional pelvic MRI (T1WI, T2WI, DWI-ADC) using GAN. MRI scans included 697 rectal cancer patients from two hospitals. Results: Quantitative and qualitative evaluation of three-channel VTE was significantly better than that of two-channel and one-channel (P＜0.001). The T staging accuracy of VTE was comparable with that of RTE. Impact: VTE synthesized by deep learning based on noncontrast MRI can overcome the limitations of RTE and aid in the clinical diagnosis and management of rectal cancer as a noninvasive, save, affordable and time-saving method that does not require GBCAs.
Multiparametric MRI as a Diagnostic Tool for Metabolic Dysfunction-Associated Steatotic Liver Disease
Authors: Wassenaar Nienke , van Son Koen , Troelstra Marian , Driessen Stan , Mak Anne Linde , Shumbayawonda Elizabeth , Nieuwdorp Max , Verheij Joanne , Nederveen Aart , Holleboom Adriaan , Gurney-Champion Oliver
Published: November 2024

Motivation: The reference standard for diagnosing Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) is invasive liver biopsy. There is a need for non-invasive diagnostic methods to assess MASLD. Goal(s): The goal was to determine if multiparametric MRI, including cT1-mapping, MR elastography, intravoxel incoherent motion diffusion-weighted MRI and proton-density fat fraction, can effectively diagnose metabolic-dysfunction-associated steatohepatitis (MASH). Approach: The diagnostic potential of multiparametric MRI parameters was assessed in 75 MASLD patients from the ongoing Amsterdam MASLD cohort study ANCHOR. Results: Results demonstrated that multiparametric MRI can play a role in diagnosing MASLD stages, providing an alternative non-invasive diagnostic method to liver biopsies. Impact: This research enables non-invasive diagnosis of Metabolic-Dysfunction-Associated Steatotic Liver Disease by combining cT1, MRE stiffness, and blood marker AST. This provides an alternative to liver biopsy, allowing assessment of the entire liver, which could significantly impact clinical practice and trials.
Mapping cerebrovascular reactivity and vascular lag in gliomas with multi-echo BOLD fMRI and breath-holding
Authors: Comella-Luengo Cristina , Quiñones Ileana , Gil-Robles Santiago , Pomposo Iñigo , Carreiras Manuel , Caballero-Gaudes César
Published: November 2024

Motivation: Cerebrovascular reactivity (CVR) with BOLD fMRI during breath-holding offers a feasible technique for examining neurovascular alterations in tumor-affected regions. However, this examination may have reduced accuracy due to breath-hold-induced artifacts. Goal(s): This study explores the use of multi-echo fMRI techniques to improve the accuracy and reliability of CVR mapping and vascular lag estimation in glioma patients. Approach: We employed optimized ME-fMRI procedures in 21 patients with diverse glioma characteristics, including lagged regression analysis, nuisance modeling with ME-ICA. Results: Our protocol robustly mapped reductions in CVR in all patients, and showed the vascular lag provides differential clinically valuable insights into tumor and peritumoral areas. Impact: This work present a robust and feasible multi-echo fMRI protocol with breath-holds that enhances cerebrovascular reactivity (CVR) mapping by obtaining complementary vascular lag maps, which offer critical insights into vascular delay and vasodilatory dynamics in glioma patients
MULTI-ECHO FUNCTIONAL IMAGING ON AN ULTRA HIGH-PERFORMANCE HEAD-ONLY GRADIENT SYSTEM
Authors: Kohls Gail , Abad Nastaren , Morris H , Hood Mauren , Demarco James , Foo Thomas
Published: November 2024

Motivation: This abstract focuses on educating on how high-gradient MRI systems can utilize the multi-echo functional MRI (ME-fMRI) techniques. Goal(s): We explain the blood-oxygen-level-dependent (BOLD) signal technique and how additional echoes can improve the signal fidelity. Approach: The ME-fMRI, using three or more echoes allow for the pixelwise T2* decay to be modeled, and as BOLD contrast is a function of T2* evolution over time, an experiment sampling the voxel-wise T2* signal decay can be used to separate BOLD from artifact signal constituents. Results: Gradient systems with ultra-rapid slew rates (> 400 T/m/s) allow ME-fMRI to reduce artefacts from flow, motion, and susceptibility effects. Impact: MRI systems with ultra-high gradient systems can reduce artefacts from flow, motion, and susceptibility effects in the BOLD contrast technique using an ME-fMRI technique with three or more echoes to improve fidelity of fMRI.
Value of Compressed Sensing in Non-Contrast Enhanced Coronary Magnetic Resonance Angiography in Elderly Patients
Authors: jiang yue , liu wenjing , yuan yong , lu guangming , chen tong , chen weibo , jin dongsheng , zhao yan e
Published: November 2024

Motivation: Coronary artery examination in elderly patients with low renal function and poor respiratory coordination has always been a clinical pain point. Goal(s): Explore the feasibility of balanced steady-state free precession BTFE sequence for non-drug coronary imaging and find the optimal compressed sensing coefficient under this sequenceApproach: Acquire cs4, 6, and 8 images under BTFE sequence, record acquisition time and analyze objective indicators and subjective scoresResults: CS6 can achieve relatively high imaging quality in a short timeImpact: Our study may inform efforts to more rapidly perform non-contrast enhanced coronary MRI angiography in elderly patients.
Measurement and analysis of objective indicators of ossification development in MRI of knee joint
Authors: Wang huan , li xinyu , jia xiaoqian , Wang Tianze , Guo Jianxin
Published: November 2024

Motivation: Adolescents have high sensitivity to X-ray, and MRI has the advantage of non-radiation, which has not been perfected in the assessment of adolescent bone age. Goal(s): To analyze the predictive value of MRI ossification development of knee joint with gender and age. Approach: The indexes representing epiphyseal development of distal femur and proximal tibia were selected for measurement, and the differences of epiphyseal development of distal femur and proximal tibia between different gender and different age groups were explored. Results: Males performed better on the distal femur and females on the proximal tibia for age prediction, which could be evaluated separately if necessary. Impact: The objective indicators of ossification development in MRI of knee joint have certain predictive value with gender and age, which helps to evaluate bone age objectively and accurately, and provides a new idea for epiphysis evaluation
Enhanced Fat Suppression Effect by Integrating STIR DWI with PROSET
Authors: Takano Susumu , Watanabe Katsuhiro , Obara Makoto , Honda Masatoshi , Katsumata Yasumoto , Takahara Taro
Published: November 2024

Motivation: In this study, the motivation was to improve fat signal suppression in Diffusion-weighted Whole Body Imaging with Background Body Signal Suppression (DWIBS). Goal(s): The specific goals were to evaluate the fat suppression effect of the Principle of Selective Excitation Technique (PROSET) in combination with STIR DWI (PROSET-STIR DWI) compared to conventional methods. Approach: The approach involved scanning healthy volunteers using PROSET-STIR DWI, STIR DWI and SPAIR DWI. Results: The results revealed that PROSET-STIR DWI achieved superior fat suppression for Methylene signals compared to conventional methods. Overall, PROSET-STIR DWI demonstrated enhanced fat suppression, highlighting its potential in clinical applications. Impact: The PROSET-STIR DWI technique demonstrates superior fat suppression compared to conventional methods, with notable differences in Methylene fat signals. This advance can benefit medical imaging, potentially improving cancer detection and diagnostic accuracy.
The Significance of fMRI in Surgical Planning for Tumour Resection and Epilepsy Surgery: Optimal Language Paradigms for Language Area Mapping
Authors: Luchow Shiami
Published: November 2024

Motivation: The Significance of fMRI in Surgical Planning for Tumour Resection and Epilepsy Surgery: Optimal Language Paradigms for Language Area MappingGoal(s): This paper explores the importance of fMRI in surgical planning and the most effective language paradigms for language area mapping. Approach: fMRI allows neurosurgeons to pinpoint critical brain regions responsible for language, motor function, and sensory perception. This information is pivotal in minimizing postoperative neurological deficitsResults: For epilepsy surgery, it aids in delineating the epileptogenic zone as data clearly shows increase in seizure freedom with detailed imaging identifying the true extent of the lesion. Impact: Resource for radiographers on how to perform a fMRI examination, sequence parameters and corresponding language paradigms.
Challenges in setting up an ex-vivo brain MRI protocol
Authors: Sanches Liana , Moqadam Roqaie , Drobotea Elena , Dumouchel Danae , Zeighami Yashar , Chakravarty Mallar , Dadar Mahsa
Published: November 2024

Motivation: Help MRI operators and other professionals who plan to acquire ex-vivo brain MRI Goal(s): What are the challenges in setting up an ex-vivo brain MRI protocol?Approach: This abstract shows the challenges faced during the establishment of an ex-vivo brain MRI protocol in a 3-tesla scanner. Results: We organized 2 categories of challenges our team faced: Dealing with motion and with contrast. We have detailed and illustrated each challenge and provided the learning points we thought were important. Impact: Scanning of ex-vivo specimens poses challenges. The literature doesn't present the problems faced in preparation phase. We provide realistic view of these challenges from the perspective of MRI scientists, to help other teams approach this problem with the proper orientation.
A novel paramagnetic probe for in-vivo MRI imaging of cannabinoid-1 receptor in the mouse brain
Authors: Ouyang Qi , Zhao Fei , Thompson Garth
Published: November 2024

Motivation: Localization of Cannabinoid type I receptor (CB1) across the whole brain with high temporal and spatial resolution would help a fundamental understanding of this receptor. Goal(s): We sought to develop an in vivo MRI probe suitable for the cannabinoid system. Approach: By chemically conjugating Rimonabantacid to the gadolinium chelate, we sought to create a novel paramagnetic probe TC1648·Gd. Introduction of this drug into mouse brains furthermore permits MRI-based measurement. Results: Comparing the PET results with the TC1648.Gd, the high expression of CB1 in the hippocampus and the poor expression in the hypothalamus are highly consistent. TC1648.Gd enable imaging-based assessment of distribution of CB1. Impact: The reagent is straightforward to produce and apply, and could immediately be used in a range of preclinical biomedical contexts. In future work, the idea of conjugating paramagnetic moieties to neuromodulatory agents could be extended to create additional MRI-detectable probes.
Development in Intrinsic Neural Timescale of Hippocampal Subfields during Childhood and Adolescence
Authors: Zeng Debin , Li Qiongling , He Yirong , Dong Xiaoxi , Li Shaoxian , Bi Shenghan , Li Shuyu
Published: November 2024

Motivation: The hippocampus plays a pivotal role in cognition, hosting an intrinsic neural timescale hierarchy. Goal(s): How does this intrinsic neural timescale hierarchy within the hippocampal subfield evolve throughout childhood and adolescence?Approach: Our study encompasses 300 healthy children (6-14 years). We characterized the intrinsic neural timescale by assessing the decay of the temporal autocorrelation function (ACF) and utilized mixed-effect model to chart the developmental trajectories. Results: Group-level intrinsic timescales within hippocampal subfields show clear temporal hierarchies along the long-axis and medial-lateral axis, and show significant correlations with hippocampal functional connectome gradients. Developmental trajectories reveal significant maturation and reorganization during childhood and adolescence. Impact: Our research findings offer valuable insights into the unique patterns of INT within various hippocampal subfields. Furthermore, they shed light on the significant maturation and reorganization of the temporal integration and segregation structure that occurs during the onset of puberty.
EPI Distortion Correction using FSL TOPUP for Diffusion Tensor Imaging of the Human Heart
Authors: Yin Gang , Sun Peng , Wu Zhigang , Dong Zhixiang , Zhu Leyi , Yan Weipeng , Liu Lele , Zhang Xiaoxiao , Lin Liangjie , Wang Jiazheng , Zhao Shihua , Lu Minjie
Published: November 2024

Motivation: Cardiac diffusion tensor imaging (cDTI) enables the characterization of the myocardial microstructural environment. However, B0 inhomogeneity around the heart can lead to EPI distortion and signal loss in cDTI. Goal(s): To investigate the feasibility of using FSL TOPUP for EPI Distortion Correction in cDTI. Approach: This proposed approach could be seamlessly integrated into cDTI postprocessing, significantly improving the accuracy and reproducibility of cDTI, particularly when researchers are analyzing metrics alongside other cardiac image parameters. Results: The FSL TOPUP method could correct EPI distortion in both diffusion-weighted images (b0 and b400), following which kinds of cDTI metrics are reconstructed successfully after the correction. Impact: The FSL TOPUP algorithm has been successfully integrated into the cDTI postprocessing in order to correct EPI distortion effectively.
Comparison of Magnetic Resonance Imaging–Based and Conventional Measurements for Proton Beam Therapy of Uveal Melanoma
Authors: van Haren Guido , Ferreira Teresa Goncalves , Beenakker Jan Willem , Jaarsma-Coes Myriam
Published: November 2024

Motivation: Proton therapy is a relatively new option for treatment of uveal melanomas. For adequate treatment, accurate measurement of tumour dimensions and tumour-marker distance is essential. The dedicated MRI protocol for uveal melanoma patients developed in our institution could be helpful. Goal(s): In this study, we compared MRI-based measurements with conventional ophthalmic measurements. Approach: Retrospectively, MRI based measurements of tumour dimensions and marker-tumour distances in 23 patients were compared with conventional ophthalmic measurements and evaluated. Results: MRI allowed for the three-dimensional assessment of the tumour. In specific patients, it provided a more reliable measurement of tumour dimensions and marker-tumour distances. Impact: Dedicated ocular MRI proved to be a reliable tool for measurements required in the planning of proton therapy in patients with uveal melanoma.
Abbreviated liver MRI (AMRI) as a surveillance method for hepatocellular carcinoma in high risk patients
Authors: Oliveira Helena
Published: November 2024

Motivation: The low sensitivity of liver ultrasound precludes the diagnosis of hepatocellular carcinoma, which led to an increased interest in abbreviated liver mri as an alternative diagnostic toolGoal(s): The goal of this research study was to assess the diagnostic performance of abbreviated liver MRI for the diagnosis of hepatocellular carcinomaApproach: This study is a literature review, in which the latest available literature relevant to the topic was assessed with the intent of answering the research questionResults: Liver AMRI shows higher sensitivity than ultrasound for diagnosis of HCC and its diagnostic performance is comparable to that seen in a conventional protocolImpact: In summary, liver AMRI should be considered as an altertative strategy to ultrasound for HCC surveillance. Future research including prospective studies, cost-effectiveness assessments and a consensus on an ideal AMRI protocol should be carried out.
The role of magnetic resonance in the diagnosis of intracranial berry aneurysm: A case report
Authors: RASHID KARIM Abdul , Donkor Anita Nsiah , Yakubu Ahmed
Published: November 2024

Motivation: Headaches associated with intracranial aneurysms are often misdiagnosed and poorly understood in the Ghanaian population. Goal(s): Our goal was to use gadolinium-enhanced MR angiography to radiologically describe features of intracranial berry aneurysm (IBA) in a clinically asymptomatic patient presenting with right-sided headaches. Approach: Axial, sagittal and coronal brain MR angiography was conducted with 50 mg/ml gadolinium contrast and radiologically evaluated. Results: A right posterior communicating artery aneurysm was found, suggesting compression of the oculomotor nerve which is characteristic of IBA. Impact: The imaging findings could help physicians to better understand, diagnose and treat the underlining causes of constant right-sided headaches which may otherwise be poorly managed by patients themselves through self-medication as is the current practice in the Ghanaian setting.
Grafik Tasarımın İlham Verici Alanları: Logo Tasarımı
Authors: Uslu Yaşar , Erşanlı Taş Banu , Atasoy Seda Nur , Çetinkaya Selin , Erarslan Behiye Aycan , Ünsür Dilek Nur
Published: November 2024

Grafik tasarım, yaratıcılığın ve stratejinin harmanlandığı, iletişimin görsel dil aracılığıyla güçlü bir şekilde ifade edildiği bir disiplindir. Bu alanın önemli bir unsuru olan logo tasarımı, markaların kimliklerini oluşturma ve hedef kitleleriyle anlamlı bağlar kurma sürecinde merkezi bir rol oynamaktadır. Elinizdeki bu eser, “Grafik Tasarımın İlham Verici Alanları: Logo Tasarımı” başlığı altında, grafik tasarımın temel taşlarından biri olan logo tasarımını derinlemesine inceleyerek okuyuculara hem teorik hem de pratik bilgiler sunmayı amaçlamaktadır.
Kitapta yer alan bölümler, logo tasarımına dair farklı boyutları ve yaklaşımları ele almaktadır. Amblem tasarımı, görsel kimliğin yapı taşı olan logoyu anlamamıza rehberlik ederken; dünyanın en iyi logo tasarımcılarının çalışmaları, küresel anlamda kabul görmüş tasarımcıların ürettikleri tasarımlar sayesinde markaların tüketiciyle kurduğu bağa ışık tutmaktadır. Türk logo tasarımında öne çıkan isimler bölümü ise yerel bir perspektif sunarak Türk grafik tasarım sahnesindeki yaratıcı gücün altını çizmektedir. Ayrıca, başarılı logo tasarımlarının incelendiği bölüm, okuyuculara ilham vermeyi ve bu alanda bir rehber işlevi görmeyi hedeflemektedir. Logolardaki mitolojik ve felsefi unsurlar, tasarımlara derinlik ve anlam katarken; logotayp kavramı, yazı tiplerinin ve görsel öğelerin bir araya geldiği yaratıcı süreci analiz etmektedir.
Bu kitap, grafik tasarım alanında çalışan akademisyenler, profesyoneller, öğrenciler ve tasarıma ilgi duyan tüm bireyler için kapsamlı bir kaynak niteliği taşımaktadır. Grafik tasarımın teorik altyapısını geliştirmek ve uygulama süreçlerine dair ilham vermek amacıyla hazırlanmıştır. Kitabın sunduğu bakış açısı, okuyucuların hem küresel hem de yerel perspektifleri harmanlayarak tasarım anlayışlarını genişletmelerine olanak sağlayacaktır.
Editörler olarak bu eserin, logo tasarımı alanında araştırma yapmak isteyenler için bir referans noktası oluşturacağına ve grafik tasarımın yaratıcı dünyasına katkıda bulunacağına inanıyoruz. Her biri alanında uzman akademisyenlerin kaleme aldığı bu bölümler, teori ve pratiği birleştiren özgün yaklaşımlarıyla dikkat çekmektedir. Kitabın tasarım dünyasına yeni ufuklar açmasını ve ilham kaynağı olmasını dileriz.
Saygılarımızla,
Nihat ALTUNTEPE ve Gökçin ÇUBUKCU
Tüketici̇ Güven Endeksi̇ ile Makroekonomik Değişkenler Arasındaki̇ İlişkinin Ekonometrik Analizi̇
Authors: Yalçın Kayacan Eda , Moralı Tuncay , Akoğul Serkan
Published: November 2024

Türkiye İstatistik Kurumu (TÜİK) tarafından her ay açıklanan Tüketici Güven Endeksi (TGE)., tüketicilerin bireysel finansal durumlarına ve gelecek beklentilerine odaklanarak harcama ve tasarruf eğilimlerini ölçmeyi amaçlamaktadır. Bu çalışmanın temel motivasyonu, tüketiciler için belirleyici olduğu düşünülen kredi faiz oranı, enflasyon, dolar kuru değişkenleri ile tüketici güven endeksi arasındaki ilişkiyi ortaya koymak ve belirleyici değişkenlerin tüketici güvenini nasıl etkilediğini incelemektir.
Tüketici güven endeksi ile tüketici kredileri, konut kredileri, taşıt kredileri, enflasyon ve döviz kurları arasında uzun dönemli anlamlı bir ilişkinin test edilmesinin amaçlandığı çalışmada Mayıs 2012-Eylül 2023 dönemlerine ait aylık veriler kullanılmıştır. Bu amaçla değişkenler arasındaki ilişki yapısal kırılmayı dikkate alan Gregory-Hansen Eşbütünleşme Testi ile test edilmiştir. Anlamlı ilişkilerin tespit edilmesinin ardından değişkenlerin uzun dönem katsayıları Tam Değiştirilmiş En Küçük Kareler (FMOLS), Dinamik En Küçük Kareler (DOLS) ve Kanonik Eşbütünleşme Regresyonu (CCR) yöntemleri kullanılarak tahmin edilmiştir. Ayrıca tüketici güven endeksi ve alt endeksleri ile tüketici kredileri, konut kredileri, taşıt kredileri, enflasyon ve döviz kurları arasındaki ilişkiler korelasyon analizi ile incelenmiş, göstergeler arasındaki ilişkiler hem istatistiksel hem de ekonometrik olarak detaylı bir şekilde değerlendirilmiştir.
Banka Sektöründe Otomatik Makine Öğrenme Yöntemi (DataBlender) ile Vadeli Mevduat Talep Tahmini
Authors: Aydın Gizem , Yalçın Mehmet
Published: November 2024

Günümüzde şirketlerin, müşteri havuzlarından doğru kişilere ulaşarak ürünleri ve hizmetleri pazarlaması oldukça önemli hale gelmiştir. Bu durum, bankacılık ve finans kuruluşları için de geçerlidir, çünkü büyük müşteri kitlesi içinden doğru kişilere ulaşmak maliyetli ve zaman alıcı bir süreç olabilmektedir. Bu doğrultuda kurumlar, ürün ve hizmetleri satın alan müşterileri içerisinden demografik ve finansal verilerini kullanarak makine öğrenmesi tabanlı modellerini arttırmışlardır. Bu modellerin hem doğru kişileri tespit ederek başarılı sonuçlar çıkarması hem de zaman ve para maliyetini azaltması bu teknolojiye olan ilgiyi arttırmıştır. Makine öğrenmesi tabanlı modeller bu doğrultuda sıklıkla kullanım imkânı bulmaktadır.
Bu çalışmada, Portekiz’deki finans kuruluşunu tercih eden müşterilerin vadeli mevduatı alıp almayacağı üzerine tahmin modelleri kurulmuştur. Böylece kuruluş, vadeli mevduata abone olma şansı daha yüksek olan mevcut müşterileri belirleyecek ve pazarlama çabaları ile bu müşterilere odaklanacaktır. Çalışmada; Portekiz’deki finans kuruluşunun, müşterilerini arayarak vadeli mevduat hesabı isteyip istemediği bilgisinin tutulduğu veri seti kullanılmıştır. Veri ön işleme adımları ile modelleme işlemleri otomatik bir şekilde yapılmış ve bunun için “DataBlender” otomatik makine öğrenmesi uygulaması kullanılmıştır. Çalışma sonucunda modeller içerisinden “LightGBM” modeli en başarılı model çıkmıştır. Sonuçlar neticesinde ağaç temelli modellerin başarı ölçütlerinin birbirine yakın olduğu gözlenmiştir. Vadeli mevduat hesabı isteyip istemediği hedef değişkeni üzerindeki etkili değişkenler, model sonucunda bulunarak müşteriye ait özellikler sıralanmıştır.
Producing CPI During Covid-19 Period in Türkiye
Authors: Metin Furkan , Demir İbrahim , Baş Cem
Published: November 2024

The first Covid-19 national lockdown was decelerated on 11 March 2020 in Türkiye. The full lockdown process has made it difficult to collect the data necessary for both household budget surveys and consumer price index in Türkiye. Nevertheless, these challenges of Covid-19 have forced national statistical offices to produce reliable, qualified and timely consumer price statistics through using alternative data sources such as scanner data and web scraping data. In this paper, experiences gained by the Turkish Statistical Institute to overcome the difficulties arise by Covid-19 have been shared. It is noteworthy that during the Covid-19 pandemic, Turkish Statistical Institute (TurkStat) successfully raised the proportion of prices essential for the Consumer Price Index (CPI) sourced from alternative data from 0% to approximately 49% within a span of just one to two years.
COLOR ABERRATIONS IN SEVEN BIRD SPECIES IN COSTA RICA
Authors: López Lucía I. , Mora Jose Manuel , Alvarado Rivera Adrián
Published: November 2024

Although there are 935 species of birds in Costa Rica, scientific reports of pigmentation abnormalities in this group are limited. Nevertheless, several cases have been recently documented, including Leucism, Ino mutation, Progressive Graying, Dilution, and two unusual color aberrations in a toucan and a motmot. Here we describe seven cases of color aberrations observed over a period of five years in native birds of Costa Rica. An Eastern Wood-Pewee Contopus virens and a White-collared Manakin manacus candei were Brown. A Scintillant Hummingbird Selasphorus scintilla and a Talamanca Hummingbird, Eugenes spectabilis, also showed a Brown mutation, however, these two cases may be Ino. In addition, two cases of Progressive Graying were recorded in a Gray-necked Wood-rail Aramides cajaneus and a Great-tailed Grackle Quiscalus mexicanus. An indeterminate case was also observed in the Turkey Vulture Cathartes aura. Identifying plumage abnormalities in wild birds is challenging and can lead to misidentifications. However, documentation of color variation and behavior in birds can help inform future research. We encourage the reporting of observations of abnormally colored birds to further our understanding of this phenomenon.
Perlindungan Hak Ekonomi Pemegang Hak Cipta Atas Lagu Menurut Undang-Undang Nomor 28 Tahun 2014 Tentang Hak Cipta
Authors: Plumbantoruan Christopher , Saidin Saidin , Runtung Runtung
Published: November 2024

Industri musik Indonesia berkembang pesat, menciptakan peluang ekonomi sekaligus tantangan dalam melindungi hak cipta di era digital. UU No. 28 Tahun 2014 tentang Hak Cipta hadir untuk memperkuat perlindungan ini, termasuk hak ekonomi pemegang hak cipta atas lagu. Penelitian yuridis normatif ini mengkaji syarat dan prosedur izin penggunaan lagu, kewenangan Lembaga Manajemen Kolektif (LMK), serta mekanisme penyelesaian sengketa. Hasilnya menunjukkan bahwa pengelolaan hak cipta lagu di Indonesia melibatkan proses kompleks, di mana pengguna harus mengidentifikasi pemegang hak cipta, mengajukan permohonan rinci, dan menyepakati syarat penggunaan. LMK berperan sebagai perantara dengan kewenangan non-eksklusif dalam pemberian lisensi blanket dan pengelolaan royalti. UU No. 28 Tahun 2014 menyediakan berbagai opsi penyelesaian sengketa, dari alternatif penyelesaian sengketa hingga proses di Pengadilan Niaga, bertujuan memberikan perlindungan hukum efektif bagi pemegang hak cipta sambil mendorong penyelesaian damai. Sistem ini dirancang untuk menyeimbangkan kepentingan pencipta, pengguna, dan industri musik secara keseluruhan.
Pesquisas e Ações em Saúde Pública - Edição XIX
Authors: Barroso L. De Freitas Guilherme , Flávia Palhares Resende Ana
Published: November 2024

A Editora Pasteur apresenta com muito prazer a 19ª edição da coletânea de capítulos sobre Saúde Pública. Essa é uma área de interesse internacional, onde comunidades com realidades diversas trocam experiências com o objetivo de reduzir custos e
Factors associated with the utilization of contraceptives among teenagers in western Uganda: a cross-sectional study
Authors:   Department of Public Health, Faculty of Health Sciences, Uganda Martyrs University, Kampala, Uganda, Thembo Moses ,   Faculty of Allied Health sciences, Kampala International University, Uganda, Andinda Maureen ,   Department of Public Health, Faculty of Health Sciences, Uganda Martyrs University, Kampala, Uganda, Ikiriza Antony ,   Department of Public Health, Faculty of Health Sciences, Uganda Martyrs University, Kampala, Uganda, Nanyingi Miisa ,   Department of Public Health, Faculty of Health Sciences, Uganda Martyrs University, Kampala, Uganda, Lwenge Mathias ,   Department of Public Health, Faculty of Health Sciences, Uganda Martyrs University, Kampala, Uganda,   Uganda Allied Health Examinations Board P.O BOX 22733 Kampala Uganda
Published: November 2024

Teenage pregnancy continues to be a significant public health concern in Uganda, with approximately one thousand cases reported daily. The lack of access to and underutilization of contraceptives contribute to this issue. We aimed to investigate the factors associated with the utilization of contraceptives among teenagers. This cross-sectional study collected data on socio-demographics, health facility-related factors, access to contraceptive information and contraceptive utilization from 409 teenagers aged 13–19 years in Ntandi Town Council in Bundibugyo, western Uganda. Prevalence ratios (PR) with 95% confidence intervals were estimated using a modified Poisson regression analysis with robust standard errors to determine factors associated with contraceptive utilization considering significant factors with a p-value <0.05. The utilization of contraceptives among teenagers aged 13 to 19 years in Bundibugyo District was 53.1% (n=217 / 409) 95%CI=48.1% – 58%). The factors associated with contraceptive utilization included: being an older teenager (17-19 years aPR=0.931, 95%CI=0.87 – 0.99), being employed (aPR=2.177, 95%CI=1.06 – 4.48) teenagers having 3 to 4 children (aPR =1.28, 95% CI = 1.05–1.56), having attained a secondary education (aPR =1.37, 95% CI = 1.13–1.67), distance to the nearest health facility (aPR =1.07, 95% CI = 1.02–1.13), and preferred health facility type (preferring a Health Centre IV: aPR=1.050 95%CI=1.00 – 1.10); preferring a hospital: aPR =1.070, 95% CI = 1.02-1.12). The utilization of contraceptives was high 53.1% as compared to Uganda’s 2030FP commitment of 39.6% by 2025 for all women. When targeting intervention for contraceptive utilization, emphasis should be put on younger teenagers and those with index pregnancies. Further research can be done on why teenagers prefer to receive contraception services from higher cadre facilities.

Keywords: Contraceptive utilization, Teenagers, Early pregnancies, Bundibugyo District
Exploring the Economic Impact of Digital Currencies on Traditional Financial Systems: Challenges and Opportunities
Authors: Juminawati Sri , Macpal Stelly Julia , Santorry Santorry , Putri Rayyanah , Tuwi I Wayan
Published: November 2024

This study investigates the economic impact of digital currencies on traditional financial systems, focusing on the challenges and opportunities that arise from the integration of digital assets into mainstream finance. Using a qualitative approach based on literature review and library research, this article synthesizes existing research to examine how digital currencies—particularly cryptocurrencies and central bank digital currencies (CBDCs)—are reshaping the global financial landscape. The analysis reveals that digital currencies present opportunities for enhanced financial inclusion, reduced transaction costs, and improved efficiency in cross-border payments. However, these benefits are accompanied by significant challenges, including regulatory uncertainty, cybersecurity risks, and potential disruptions to monetary policy and financial stability. As digital currencies continue to evolve, their growing influence demands coordinated regulatory frameworks and technological adaptations within traditional financial institutions. This study contributes to a deeper understanding of how digital currencies impact economic structures, offering insights that can guide policymakers, financial institutions, and investors in navigating the transformation of financial ecosystems. By addressing both the advantages and challenges, the research highlights the importance of a balanced approach to digital currency adoption that fosters innovation while mitigating risks.
Normas de estilo e instrucciones para los autores
Authors:   Instituto de Derechos Humanos
Published: November 2024

Normas de estilo e instrucciones para los autores
Pelvic Exenteration for locally advanced rectal cancer (LARC) and locally recurrent rectal cancer (LRRC) in Greece: A national snapshot survey of current practice
Authors:   Greek Pelvic Exenteration Collaborative
Published: November 2024

Background: Surgical treatment of locally advanced rectal cancer (LARC) and locally recurrent rectal cancer (LRRC) relies on Pelvic Exenteration, a complex procedure with high morbidity and mortality rates and great disparities in practice across different centers internationally. The aim of this survey is to review the current perioperative management of LARC and LRRC in Greece.

Material and Methods: National Snapshot Survey disseminated online by the Hellenic Surgical Society and Greek Society of Coloproctology.

Results: Most respondents were surgeons, 22% of whom had received fellowships in pelvic exenteration surgery. 83% of the participants reported holding multidisciplinary team meetings, and typically fewer than 10 pelvic exenteration procedures are conducted annually. A total of 28% of the participants employ a validated classification system to describe the operative approach (Pelvic Exenteration Lexicon). Considering outcomes, surgical factors like length of stay (78%), ICU duration (72%), blood loss (70%) and number of blood transfusions (64%) were prioritised, whereas patient-reported outcomes focused on physical functioning (77%), quality of life (75%), and urinary function (75%). For urological reconstructions, percutaneous nephrostomy (87%), cutaneous ureterostomy (75%) and urinary diversion using an ileal conduit (73%) were utilised the most, while plastic reconstructions involved mainly mesh placement (72%), omental flap with/without a skin graft (70%) and pedicled flaps (58%). Most prevalent complications were perineal wound dehiscence, abdominal wall hernia, postoperative ileus, urinary infection and VTE.

Conclusion: Due to its complexity and low volume, experience in LARC/ LRRC is dispersed and differs among individuals. There is a need for structured, validated national guidelines to standardise methods and ensure that patients receive the highest standard of care.
L’accompagnement entrepreneurial par un écosystème en faveur du développement touristique : le parc Picardia
Authors: FOURNIER Sandrine
Published: November 2024

This article looks at the creation of the first indoor leisure park 2.0 in France. This longitudinal study, based on semi-structured interviews, supplemented by observation and documentary analysis, describes the support and guidance given to private entrepreneurship by public officials in favor of the project. The results, presented according to the process of entrepreneurial stages, i.e. from the idea to its opening, reveal how an idea initiated by private entrepreneurs will be seen as an opportunity to add to the attractiveness of the region, and will benefit from the support of an ecosystem, including the taking of financial risks.
Neology and lexical appropriation in the francophone area: case of lexical particularities of spoken French in Burkina Faso
Authors: KOURAOGO Yacouba
Published: November 2024

Forty years ago, the IFA Team published The Inventory of the Lexical Particularities of French in Black Africa ?L?Inventaire des particularit?s lexicales du fran?ais en Afrique noire? (?quipe IFA, 1983). Since then, the lexical particularities of French in Africa have sparked renewed interest in lexicological research, lexicographical practices and even vocabulary teaching. As the language evolves through its enrichment through the creation of neologisms, we see new lexical forms emerging nowadays in the different varieties of French in Africa. If the emergence of a regional lexicon is not without consequences on the lexical system of the language, it goes without saying that these lexical particularities, which are mainly the result of new lexicogenetic processes, considerably impact the lexical system of French. Such an observation is legitimized by the specific case of French spoken in Burkina Faso where new lexical particularities are legion offering new avenues for reflection. These lexical particularities are flowing more and more into formal or standard French, since it is not uncommon to encounter them in language dictionaries, in teaching and in media, political, administrative and scientific discourse. They therefore constitute a reserve of words, even a potential lexicon, for the French language. The present study is interested in these lexical particularities, in order to determine, on the one hand, the lexico genetic mechanisms that they induce in the overall functioning of French and, on the other hand, the reasons for their existence in that language.
The Conclusion and Completion of the Gift in Sudanese Law: A Comparative Study
Authors: Idris Ibrahim , Masaad Masaad
Published: November 2024

The study addressed the subject of the conclusion and completion of the gift in Sudanese law, some Arab countries’ laws and Islamic jurisprudence. The study showed that the gift is concluded by an offer only and is not dependent on acceptance from the donee according to the Hanafi School, except for Zafar. According to the majority, the gift is concluded by an offer and acceptance, and the laws (Sudanese, Lebanese, Egyptian and Saudi) agree with the opinion of the majority. The study also showed that the gift of real estate is a formal contract in the laws (Egyptian, Lebanese and Saudi), and that the gift of movable property may be a formal contract if it is completed in the manner required by law, and it may be a real contract if it is completed by taking possession. Regarding the effect of seizure on the gift, the study showed a difference in the classification of seizure as a condition in the contract, as in Sudanese law it is a condition of completion, in the Hanafi school it is a condition of validity (and it was said a condition of completion), and in the Shafi'i and Hanbali schools it is a condition of obligation, but despite this difference the result in each is the same, as the contract is valid before seizure, but it is not executed - i.e. the ownership is transferred from the donor to the donee - and is not binding unless the donor voluntarily delivers the gifted thing to the donee, i.e. the donor has the option to take possession or not without being obligated to do so. The study also showed that seizure is a pillar in the gift of movable property in some of the laws referred to, which is consistent with the statement of Zafar from the Hanafis, who went on to say that seizure is a pillar in the gift.
Obinutuzumab Infusion-Related Reactions: Multicenter Retrospective Evaluation of Incidence, Severity, and Risk Factors
Authors: Hickey Zacholski, PharmD, BCOP Erin , Rugh, PharmD Candidate Sarah , Marshall, PharmD Candidate Jenna , Nadpara, PhD Pramit , C. Moore, PharmD, BCOP, DPLA, FCCP Donald
Published: November 2024

Introduction: Despite standard prevention strategies, obinutuzumab carries a significant risk of infusion-related reactions (IRRs) for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Reported rates of IRRs vary in phase III clinical trials evaluating obinutuzumab-containing regimens. Although obinutuzumab has a higher rate of severe (grade 3 and higher) IRRs than rituximab, clinical risk factors predicting IRR have not been identified, and therefore strata informing patient-specific risk of IRR have not been applied in practice. Methods: This multicenter, retrospective evaluation of patients with CLL/SLL estimated the incidence of obinutuzumab-related IRRs and evaluated risk factors for the development of IRR in a real-world population. Results: 68 patients with untreated or previously treated CLL/SLL were included in the analysis, with the majority being older adult (median age = 70) males (61.8%) with Rai stage III and IV CLL. All-grade IRRs occurred in 25% of patients, and severe IRRs occurred in 1.5% of patients. Of the variables evaluated, absolute lymphocyte count was a significant predictor (p ≤ .05) of the odds of experiencing an IRR in patients receiving obinutuzumab. Conclusion: Obinutuzumab IRR rates in a real-world population were comparable to most phase III clinical trial results succeeding implementation of split dosing and standard premedication. Absolute lymphocyte count is a statistically significant predictor for increased odds of experiencing an IRR. Future research evaluating risk-adapted obinutuzumab administration strategies is needed to recommend a specific approach.
KICHIK VA O’RTA BIZNES KORXONALARIDA BILIMLAR BOSHQARUV TIZIMINI JORIY QILISHDA MUHIM OMILLAR
Authors: Qosimova Dilorom , Kabulova Nurgo’zal
Published: November 2024

Maqolada kichik va o’rta biznesda bilimlar boshqaruv tizimini muvaffaqiyatli yo’lga qo’yish va ularni amaliyotga joriy qilishda qaysi omillar muhim rol tutishini izchil tadqiq qiladi. Tadqiqotning asosiy maqsadi kichik va o'rta korxonalarni bilimlar boshqaruv tizimini qanday joriy qilinisshiga ta'sir qiluvchi turli omillarni ko'rib chiqish. Bu omillar to'rtta asosiy yo'nalishga birlashtirilgan: texnologiya, tashkilot, atrof-muhit va inson xulq-atvori.
SANOAT TARMOQLARINI HUDUDIY RIVOJLANTIRISHNING TASHKILIY-IQTISODIY MEXANIZMLARI
Authors: Raximov Anvar
Published: November 2024

Maqolada sanoat tarmoqlarini hududiy rivojlantirishning tashkiliy-iqtisodiy mexanizmlari hozirgi kundagi dolzarb mavzulardan biri ekanligi, hamda uni oshirishga qaratilgan bir qancha olimlarning fikr-mulohazalari bayon etilgan. Sanoat tarmoqlarini hududiy rivojlantirishning tashkiliy-iqtisodiy mexanizmlari sxema ko‘rinishda, sanoat tarmog‘ining hududiy ixtisoslashuv strukturasi ko‘rsatib o‘tilgan. Sanoat rivojlanishining tabiiy resurslarga bog‘liqligi, sanoat tarmoqlarining o‘zaro energiya ta’minoti grafigi, sanoatning telekommunikatsiya va axborot texnologiyalari (ICT) bilan bog‘liqligi yoritilib berilgan va bu bo‘yicha xulosa va takliflar berilgan.