bluuebunny/crossref_metadata_2025 huggingface dataset:
Decreased lateral posterior tibial slope and medial tibial depth are underlying anatomic risk factors for posterior cruciate ligament injury: a case–control study
Authors: Yin Baoshan , Zhao Pei , Chen Jiaxing , Yan Wenlong , Zhang Hua , Zhang Jian , Zhou Aiguo
Published: July 2022

Objectives

To research whether medial PTS, lateral PTS and MTD were different between the PCL injury group and the PCL intact group.

Design

Retrospective case–control study, level of evidence III.

Methods

Fifty patients with PCL rupture from 2015 to 2020 in our hospital, and 50 patients matched by age and sex with intact PCL were enrolled in our study. The intraclass correlation coefficient (ICC) was used to assess the reliability of each parameter. The independent t-test was conducted to identify the differences in tibial morphometric characteristics between the PCL-injured and PCL-intact individuals, including the posterior tibial slope (PTS), meniscal slope (MS), medial tibial depth (MTD). A binary logistic regression model was established to evaluate the roles of those anatomic parameters of interest play in PCL injuries.

Results

The interobserver reliability of each parameter showed excellent agreement. Significant differences in the medial (P = .023) and lateral (P = .009) PTS were found between the PCL-injured group (3.68 ± 2.70 and 4.55 ± 3.19, respectively) and the controls (5.00 ± 2.73 and 6.39 ± 3.29, respectively). And the MTD was 1.98 ± 0.64 mm in the PCL-injured group and 2.37 ± 0.55 mm in the control group (P = 0.007). Binary logistic regression analysis showed that smaller lateral PTS and MTD were directly associated with PCL injury, with an OR of 1.17 and OR of 3.14, respectively. The medial PTS was independent to PCL injures.

Conclusion

Decreased lateral PTS and MTD were underlying anatomic risk factors for PCL injury.
Antibacterial and antibiotic-potentiation activity of the constituents from aerial part of Donella welwitshii (Sapotaceae) against multidrug resistant phenotypes
Authors: Guefack Michel-Gael F. , Ngangoue Marcelle O. , Mbaveng Armelle T. , Nayim Paul , Kuete Jenifer R. N. , Ngaffo Carine M. N. , Chi Godloves F. , Ngameni Bathelemy , Ngadjui Bonaventure T. , Kuete Victor
Published: July 2022

Background

The rise of multidrug-resistant (MDR) bacteria is a real public health problem worldwide and is responsible for the increase in hospital infections. Donella welwitschii is a liana or shrub belonging to the family Sapotaceae and traditionally used to cure coughs.

Objective

This study was conducted with the objective to validate the medicinal properties of this plant, the aerial part was studied for its phytochemical composition using column and PTLC chromatography and exploring its antibacterial and antibiotic-modifying activity as well as those of its phytochemicals.

Methods

The structures of the compounds were elucidated from their physical and spectroscopic data in conjunction with literature. The antibacterial activity of the isolated metabolites was performed toward a panel of MDR Gram negative and Gram-positive bacteria. The broth micro-dilution method was used to determine antibacterial activities, efflux pump effect using the efflux pump inhibitor (EPI) (phenylalanine-arginine-ß-naphthylamide (PAβN)), as well as the modulating activity of antibiotics. Monitoring the acidification of the bacterial growth medium was used to study the effects of the samples on the bacterial proton-ATPase pumps and cellular ATP production.

Results

Eleven compounds were isolated including pentacyclic triterpenes, C-glucosyl benzophenones. With a MIC value < 10 μg/mL, diospyric acid (7) significantly inhibited the growth of Escherichia coli AG102, Enterobacter aerogenes ATCC13048, Klebsiella pneumoniae KP55, Providencia stuartii NEA16 and Staphylococcus aureus MRSA3. 28-hydroxy-β-amyrin (8) significantly impaired the growth of Enterobacter aerogenes EA27, Klebsiella pneumoniae ATCC11296 and Staphylococcus aureus MRSA6; and oleanolic acid (9) strongly impaired the growth of Escherichia coli AG 102, Enterobacter aerogenes EA27 and Providencia stuartii PS2636. Diospyric acid (7) and 28-hydroxy-β-amyrin (8) induced perturbation of H+-ATPase pump and inhibition of the cellular ATP production. Moreover, at MIC/2 and MIC/4, compounds 7, 8, and 9 strongly improved the antibacterial activity of norfloxacin, ciprofloxacin and doxycycline with antibiotic-modulating factors ranging between 2 and 64.

Conclusion

The overall results of the current work demonstrate that diospyric acid (7), 28-hydroxy-β-amyrin (8) and oleanolic acid (9) are the major bioactive constituents of Donella welwitschia towards Gram-negative bacteria expressing MDR phenotypes.
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Authors: Tonomura Sotatsu , Ling Jennifer , Gu Jianguo G.
Published: July 2022

Previous immunohistochemical studies have shown the expression of KCNQ2 channels at nodes of Ranvier (NRs) of myelinated nerves. However, functions of these channels at NRs remain elusive. In the present study, we addressed this issue by directly applying whole-cell patch-clamp recordings at NRs of rat lumbar spinal ventral nerves in ex vivo preparations. We show that depolarizing voltages evoke large non-inactivating outward currents at NRs, which are partially inhibited by KCNQ channel blocker linopirdine and potentiated by KCNQ channel activator retigabine. Furthermore, linopirdine significantly alters intrinsic electrophysiological properties of NRs to depolarize resting membrane potential, increase input resistance, prolong AP width, reduce AP threshold, and decrease AP amplitude. On the other hand, retigabine significantly decreases input resistance and increases AP rheobase at NRs. Moreover, linopirdine increases excitability at NRs by converting single AP firing into multiple AP firing at many NRs. Saltatory conduction velocity is significantly reduced by retigabine, and AP success rate at high stimulation frequency is significantly increased by linopirdine. Collectively, KCNQ2 channels play a significant role in regulating intrinsic electrophysiological properties and saltatory conduction at NRs of motor nerve fibers of rats. These findings may provide insights into how the loss-of-function mutation in KCNQ2 channels can lead to neuromuscular disorders in human patients.
Hypoglycemic unawareness: challenges, triggers, and recommendations in patients with hypoglycemic unawareness: a case report
Authors: Sharifi Yasaman , Ebrahimpur Mahbube , Tamehrizadeh Seyed Saeed
Published: July 2022

Background

Hypoglycemia is a fairly common complication in diabetic patients, particularly in those on insulin therapy. Hypoglycemia symptoms are classified into two types: autonomic and neuroglycopenic symptoms. If a person develops neuroglycopenic symptoms before the appearance of autonomic symptoms or is asymptomatic until blood sugar levels are very low, the patient will develop hypoglycemic unawareness (HU).

Case presentation

A 25-year-old Iranian woman with HU presented with a severe hypoglycemic episode. This episode was characterized by loss of consciousness and focal neural deficits, which were unusual symptoms in the patient, who was a medical intern with type 1 diabetes and currently being treated with regular and NPH insulin.

Conclusions

Hypoglycemia is a common complication in diabetic patients receiving oral or insulin therapy. A patient who is unaware of their condition may experience severe and potentially fatal episodes. These incidents can negatively affect their daily lives as well as their careers and jobs. Hypoglycemia-associated autonomic failure is a possible cause for patients with multiple episodes of severe hypoglycemia. IThe use of a continuous glucose monitoring device with an alarm, if available, can be an excellent option for these patients.
Ionospheric signatures of repeated passages of atmospheric waves by the 2022 Jan. 15 Hunga Tonga-Hunga Ha’apai eruption detected by QZSS-TEC observations in Japan
Authors: Heki Kosuke
Published: July 2022

A large eruption occurred on Jan. 15, 2022, at the submarine volcano Hunga Tonga-Hunga Ha’apai, southern Pacific, and the atmospheric Lamb wave was observed to have traveled round the Earth multiple times with a speed of ~ 0.3 km/s. Here, I compare their ionospheric and atmospheric signatures using data from dense arrays of barometers and GNSS stations in Japan. I confirmed that the ionospheric disturbances passed over Japan at least four times, first from SE to NW, then from NW to SE, again from SE to NW, and finally from NW to SE. The propagation velocity of the ionospheric disturbances was as fast as the atmospheric Lamb wave, suggesting their origin as upward energy leakage from the troposphere. The first passage of the ionospheric disturbance started prior to the arrival of the Lamb pulse, but its physical mechanism is yet to be explored. Unlike the barometric records, waveforms and amplitudes of ionospheric disturbances exhibit large diversity along the wavefront, suggesting their turbulent nature.

Graphical Abstract
Decoupling between soil moisture and biomass drives seasonal variations in live fuel moisture across co-occurring plant functional types
Authors: Brown Tegan P. , Hoylman Zachary H. , Conrad Elliott , Holden Zachary , Jencso Kelsey , Jolly W Matt
Published: July 2022

Background

Wildfires are important global disturbances influencing ecosystem structure and composition. The moisture content of living and senescent plant components are key determinants of wildfire activity, yet our understanding of how seasonal fluctuations in water availability and biomass control live foliar moisture content (LFMC) across co-occurring plant functional types is limited in diverse forested landscapes.

Results

We recorded root-zone volumetric water content (VWC) and sampled leaf mass area (LMA) and LFMC of three co-occurring plant functional types across six field sites. We used a linear mixed effects model to quantify the drivers of LFMC and understand whether LFMC dynamics were coupled or decoupled from site conditions. Both LMA and VWC were significant predictors of LFMC variability (p < 0.001), although the strength and direction of these relationships varied across functional types. LFMC dynamics of understorey plant functional types were strongly coupled to site conditions, where the site random effect explained 44.2% (shrub) and 74.8% (herb) of the variability in LFMC across the season respectively. In contrast, overstorey plants were decoupled from site conditions, which explained only 8.1% of the variability in LFMC.

Conclusions

LFMC of understorey plants responded to changes in soil water availability (VWC), while overstorey trees responded to biomass fluctuations (LMA). We present a conceptual model describing the influence of these factors on LFMC, which aligns with our findings and draws on the broader literature. This knowledge and conceptual approach can be used to improve our ability to characterize seasonal LFMC variation across different plant functional types, in turn improving our capacity to predict wildfire risk.
Effect of intradialytic exercises (IDE) on maximal oxygen consumption and quality of life undergoing hemodialysis in Indian population—a pilot study
Authors: Grover Seema , Goyal Vaishali , Chorsiya Varsha , Ganguly Nirmal Kumar , Saha Gautam Kumar
Published: July 2022

Background

End stage renal disease (ESRD) is emerging as a major health issues across developing countries with limited access and awareness about the importance of exercises in daily life. People on prolong hemodialysis has difficulty in performing their activities of daily living (ADL). Loss of muscle mass is inevitable among patients on hemodialysis that leads to morbidity and mortality. Exercise is feasible during dialysis and can enhance quality of life. Increase in aerobic endurance by various combined protocol of aerobic and resistive exercises can improve compliance to regular exercise that underlines the theme of present study.

Methods

A total of 31 participants were recruited during November 2019 to February 2020, after screening of 65 participants for selection criteria from Indraprastha Apollo Hospital’s dialysis unit. The average age of the participants was 52.36 ± 11.56 years. A single-blinded, pre-test–post-test quasi-experimental clinical trial for intradialytic exercise program involving lower limb ergometer and resistance training for lower limbs and non-fistula hand for 24 sessions, in 3 months, twice a week was conducted.

Results

The exercise program was well tolerated and all patients completed it. Aerobic and resistance intradialytic exercises (IDE) had a positive effect on maximal oxygen consumption (VO2 Max), quality of life (SF 36), and sleep quality (PSQI). IDE showed statistically significant difference from pre- to post-intervention for maximal oxygen consumption, quality of life boosting their sleep quality.

Conclusions

IDE found to benefit the patient and results showed a significant improvement in maximal oxygen consumption, sleep quality, quality of life and fatigue over a span of 12 weeks.

Trial registration

CTRI, CTRI/2019/08/020848. Registered on 22 August 2019.
Responder Analysis of Pain Relief After Surgery for the Treatment of Spinal Metastatic Tumors
Authors: Rothrock Robert J. , Reiner Anne S. , Barzilai Ori , Kim Nora C. , Ogilvie Shahiba Q. , Lis Eric , Gulati Amitabh , Yamada Yoshiya , Bilsky Mark H. , Laufer Ilya
Published: July 2022

BACKGROUND:

Central tendency analysis studies demonstrate that surgery provides pain relief in spinal metastatic tumors. However, they preclude patient-specific probability of treatment outcome.

OBJECTIVE:

To use responder analysis to study the variability of pain improvement.

METHODS:

In this single-center, retrospective analysis, 174 patients were studied. Logistic regression modeling was used to associate preoperative characteristics with rating the Brief Pain Inventory (BPI) worst pain item 0 to 4. Linear regression modeling was used to associate preoperative characteristics with minimal clinically important improvement (MCI) in physical functioning defined by a 1-point decrease in the BPI Interference Construct score from preoperative baseline to 6 months postoperatively.

RESULTS:

Patient-level analysis revealed that 60% of patients experienced an improvement in pain. At least half experienced a decrease in pain resulting in MCI in physical functioning. Cutpoint analysis revealed that 48% were responders. Increasing scores on the preoperative pain intensity BPI items, the MD Anderson Symptom Inventory (MDASI) Core Symptom Severity Construct, the MDASI Spine Tumor–Specific Construct, the presence of preoperative neurologic deficits, and postoperative complications were associated with lower probability of treatment success while increasing severity in all BPI pain items, and MDASI constructs were associated with increased probability of MCI in physical function. Significant mortality and loss to follow-up intrinsic to this patient population limit the strength of these data.

CONCLUSION:

Although patients with milder preoperative symptoms are likely to achieve better pain relief after surgery, patients with worse preoperative symptom also benefit from surgery with adequate pain relief with an improvement in physical function.
Ordered Silica Nanostructure by the Calcination of Block Copolymer with Polyhedral Oligomeric Silsesquioxane (POSS) Side Chain
Authors: Iwao Sota , Kurono Naoki , Higashiguchi Wataru , Hayakawa Teruaki , Ohta Noboru , Kamitani Kazutaka , Fujii Syuji , Nakamura Yoshinobu , Hirai Tomoyasu
Published: July 2022

Silica with well-ordered line patterns and a periodicity of approximately 30 nm was prepared by the calcination of a block copolymer with polyhedral oligomeric silsesquioxane (POSS) as a template. A POSS-containing block copolymer was prepared via living anionic polymerization. The thin film of the block copolymer exhibited linear features upon CS2 vapor annealing. Cylindrical structure changed to a line morphology during calcination process.
Synthesis, Stereochemical Analysis, and Transformation of Oxa-[7]orthocyclophene
Authors: Tomooka Katsuhiko , Iso Chisato , Hashimoto Yukiho , Suzuki Masaki , Kawasaki Yuuya , Igawa Kazunobu
Published: July 2022

Planar chiral oxa-[7]orthocyclophene 1a was designed and synthesized with two different synthetic routes. X-ray crystallographic analyses of 1a and its platinum complex revealed a highly distorted ring structure and the absolute stereochemistry of 1a, respectively. Epoxidation and [2,3]-Wittig rearrangement of 1a provided with central chiral molecules, without the loss of enantiomeric purity.
Η πρόσληψη του ποιητικού λόγου των Ελληνίδων δημιουργών στο τελευταίο τέταρτο του 20ου αιώνα (1974-2000)
Authors: Παπαλεξάνδρου Αριστέα
Published: July 2022

Στην παρούσα διατριβή, επιχειρείται συστηματική καταγραφή και αποτίμηση του κριτικού λόγου για τις Ελληνίδες ποιήτριες στο διάστημα 1974-2000. Τα χωροχρονικά πλαίσια οριοθετούνται, με άξονα δύο κύριες μεταβλητές: τη μεταβλητή του χρόνου· και τη μεταβλητή ως προς το πεδίο έρευνας, που καλύπτει ένα ευρύ φάσμα εντύπων, όπου συγκαταλέγονται οι Ιστορίες Νεοελληνικής Λογοτεχνίας, οι Ανθολογίες Ποίησης, οι μονογραφίες, οι τόμοι κριτικών μελετών, τα Αφιερώματα, και βεβαίως, τα κριτικά άρθρα στον περιοδικό, αλλά και στον ημερήσιο τύπο. Ειδικά η διερεύνηση της θέσης των ποιητριών στον τύπο στάθηκε το απαιτητικότερο κομμάτι αυτή της εργασίας, καθώς αποτελεί απόρροια συστηματικής αποδελτίωσης πενήντα οχτώ (58) περιοδικών — λογοτεχνικών και όχι μόνον· μερικών φεμινιστικών εντύπων· και ενός μέρους των στηλών κριτικής βιβλίου έξι (6) σημαντικών εφημερίδων, που αποδελτιώθηκαν δειγματοληπτικά. Ακολουθείται χρονολογική, κατά βάση εξέταση, ανά δεκαετίες. Σε ό,τι αφορά τη δομή, τα δύο πρώτα κεφάλαια είναι προπαρασκευαστικά. Στο πρώτο, εκτίθενται διάφοροι προβληματισμοί, που αφορούν στη φιλολογική ή μη φιλολογική κριτική· στην πολιτική διάσταση του κριτικού λόγου· και στον παράγοντα «φύλο» στη διαμόρφωσή του. Στο δεύτερο κεφάλαιο, επιχειρείται σύντομη ανασκόπηση της κριτικής πρόσληψης του ποιητικού λόγου των Νεοελληνίδων, από τα τέλη του 19ου αιώνα έως και το 1973. Από το τρίτο έως το έβδομο —και τελευταίο— κεφάλαιο, διερευνάται η καθαυτό κριτική πρόσληψη των ποιητριών στο υπό εξέταση διάστημα. Το ογκωδέστατο υλικό που προκύπτει από τη διερεύνηση πληθώρας εντύπων στα είκοσι επτά αυτά έτη (1974-2000) αντικατοπτρίζει ένα παλίμψηστο σχολίων και γνωμών, που για πρώτη φορά παρουσιάζεται συγκεντρωτικά, γεγονός που συνιστά την ουσιαστική συμβολή αυτής της διατριβής. Η ιστορία της κριτικής πρόσληψης των Ελληνίδων, ξεκινά άλλωστε, από πολύ παλιά, και ό,τι μελετήσαμε εδώ αποδείχτηκε απόρροια πληθώρας ζυμώσεων, πολύ πριν το πρώτο υπό διερεύνηση έτος, 1974. Από τις πρώτες αχνές νύξεις περί τις εμφανίσεις τους, στα τέλη του 19ου, ώς τις επιδοκιμασίες —αλλά και τις επικρίσεις— που, καθ’ όλη την υπό εξέταση περίοδο, διατυπώνονται για το έργο τους, όταν συγκρίνονται με κορυφαίους της ελληνικής, καθώς και της παγκόσμιας διανόησης, δεν χωρεί αμφιβολία πως έχουν διανυθεί χιλιόμετρα δειλών ή/και διεκδικητικών βημάτων, και από τις γυναίκες που ασχολούνται με την ποίηση, αλλά και από την κριτική που τις είδε, ως υπολογίσιμες φωνές της νεοελληνικής λογοτεχνίας. Μία de facto, πλούσια κι ετερόκλητη, κριτική πρόσληψη της γυναικείας ποίησης έχει πλέον διαμορφωθεί, τουλάχιστον σε ό,τι αφορά δέκα-δεκαπέντε ονόματα δημιουργών, που όντας σταθερά ενεργές, αποτιμώνται ποικιλοτρόπως. Όμως και γι’ άλλες, που συνιστούν, η καθεμία με τον τρόπο της, ελάχιστες ψηφίδες της γυναικείας ματιάς πάνω στον κόσμο, έχει σχηματιστεί μία βιβλιογραφία, καθώς οι περισσότερές τους παραμένουν διαθέσιμες, σε ένα επαρκές ή μη, αναγνωστικό κοινό, πρόθυμο να τις διαβάσει.
Παραμόρφωση του στερεού φλοιού στην Αιτωλοακαρνανία με χρήση μόνιμων σταθμών GNSS
Authors: Λύρος Επαμεινώνδας
Published: July 2022

Η παρούσα διδακτορική διατριβή εξετάζει την τεκτονική παραμόρφωση στην περιοχή του νομού Αιτωλοακαρνανίας, στη Δυτική Ελλάδα, χρησιμοποιώντας δεδομένα GNSS, καθώς και τη σεισμική επικινδυνότητα της παραπάνω περιοχής. Αν και τα γενικά τεκτονικά χαρακτηριστικά της περιοχής είναι γνωστά, εντούτοις υπάρχει ανάγκη για συνεχή και λεπτομερή παρακολούθησή της. Από το 2013 η παραμόρφωση του φλοιού στην περιοχή παρακολουθείται από ένα δίκτυο GNSS, συμπληρωματικά προς το μόνιμο σεισμικό δίκτυο. Το δίκτυο GNSS PPGNet αποτελείται από πέντε σταθμούς στην Αιτωλοκαρνανία, και συγκεκριμένα στις περιοχές Κατοχή, (KTCH), Λεπενού (ΛΕΠΕ), Παραβόλα (PVOG), Ρίγανη (RGNI) και Κάτω Ρετσίνα (RETS). H εκτίμηση της σεισμικής επικινδυνότητας προσελκύει το ενδιαφέρον της επιστημονικής κοινότητας, ειδικά σε έντονα σεισμογενείς περιοχές όπου υπάρχουν σύνθετα συστήματα ρηγμάτων. Οι παραδοσιακές μέθοδοι εκτίμησης του σεισμικού κινδύνου εμφανίζουν μεγάλα προβλήματα αβεβαιότητας. Η παρούσα διδακτορική διατριβή συνοψίζει την προϋπάρχουσα βιβλιογραφία και τα κύρια μοντέλα παραμόρφωσης που έχουν προταθεί μέχρι τώρα, η κύρια μεθοδολογία της όμως για την εκτίμηση της σεισμικής επικινδυνότητας βασίζεται στην ανάλυση των κύριων ρηγμάτων. Κύριος στόχος της παρούσας διδακτορικής διατριβής είναι η εξαγωγή αξιόπιστων αποτελεσμάτων και η επίτευξη υψηλότερης χωρικής ανάλυσης εκτίμησης επικινδυνότητας στην εξεταζόμενη περιοχή της Αιτωλοακαρνανίας. Η συμπερίληψη των δεδομένων από το PPGNet παρέχει πολύτιμες πληροφορίες για την παραμόρφωση της περιοχής της Αιτωλοακαρνανίας και πώς αυτή η παραμόρφωση συνδέεται με τις κύριες ενεργές δομές στην ευρύτερη περιοχή.
Antagonistic discourses in Greece at the time of the Movement of the Squares
Authors: Καζάκου Ιωάννα
Published: July 2022

Στη διατριβή αναλύεται ο λόγος του Κινήματος των Πλατειών, της λαϊκής κινητοποίησης ενάντια στην ψήφιση του Μεσοπρόθεσμου Προγράμματος στις 29 Ιουνίου του 2011. Αναλύεται επίσης ο λόγος με τον οποίο τα ΜΜΕ παρουσίασαν τα γεγονότα εκείνης της περιόδου. Οι δύο λόγοι θεωρούνται ανταγωνιστικοί στην πάλη για το ποια νοήματα θα έχουν την ισχυρότερη επίδραση στην κοινωνία. Γι' αυτό, εξετάζονται υπό το πρίσμα της ηγεμονίας του Αντόνιο Γκράμσι. Η αντίληψη της ηγεμονίας του Γκράμσι διατρέχει τη διατριβή για έναν επιπλέον λόγο. Διότι, στο επίκεντρο της μελέτης των δύο ανταγωνιστικών λόγων βρίσκεται η κοινωνική τάξη, όπως και στον πυρήνα της γκραμσιανής αντίληψης της ηγεμονίας βρίσκεται η ταξική κυριαρχία και η αντίσταση σε αυτή. Συγκεκριμένα, η ανακατασκευή της τάξης μέσα από τον λόγο του κινήματος προηγείται της ανάλυσης του λόγου των ΜΜΕ ώστε η αποταξικοποιητική λειτουργία του λόγου των ΜΜΕ να μπορεί να ερμηνευθεί στο πλαίσιο της ηγεμονικής πάλης με το κίνημα.
Η γραφή των "Αστραπάδων"
Authors: Κόστιτς Έλενα
Published: July 2022

Στη παρούσα διατριβή αντιμετωπίζονται τα ζητήματα του συνόλου της καλλιτεχνικής παραγωγής του γνωστού εργαστηρίου βυζαντινών ζωγράφων, των λεγόμενων Αστραπάδων, τα μέλη του οποίου έδρασαν στον βαλκανικό χώρο στα τέλη του 13ου - αρχές του 14ου αι. Για πρώτη φορά στην έρευνα η γραφή αξιοποιείται ως βασικό στοιχείο μελέτης, με σκοπό την απόδοση ταυτοτήτων σε κύριους ζωγράφους, βοηθούς και μαθητές, κάτι που επιχειρείται με την συγκρότηση ειδικών δελτίων γραφικών ιδιωμάτων για τον εκάστοτε καλλιτέχνη. Η μελέτη των γραφολογικών στοιχείων ξεκινά από τα πέντε μνημεία, στα οποία σώζονται υπογραφές των καλλιτεχνών: την Παναγία Περίβλεπτο στην Αχρίδα, τον Άγιο Γεώργιο στο Staro Nagoričino, τον Άγιο Νικήτα στο Čučer, το Πρωτάτο στο Άγιο Όρος και τον Άγιο Πρόχορο της Pčinja. Στη συνέχεια, η έρευνα επεκτείνεται σε άλλα μνημεία, τα οποία, λόγω συγγενικών τεχνοτροπικών χαρακτηριστικών, αποδόθηκαν στην έρευνα στους λεγόμενους Αστραπάδες. Πρόκειται για τον Άγιο Ευθύμιο στη Θεσσαλονίκη, τα καθολικά των αγιορείτικων μονών Βατοπαιδίου και Χιλανδαρίου, το καθολικό της μονής Gračanica, την Παναγία Ljeviška και το παρεκκλήσιο των Αγίων Ιωακείμ και Άννας στη Studenica. Από την έρευνα προκύπτει ότι εν αντιθέσει προς τις παλαιότερες μελέτες οι οποίες απέδιδαν την πατρότητα των παραπάνω έργων στο ζωγραφικό δίδυμο του Μιχαήλ Αστραπά και του συνεργάτη του Ευτυχίου, αποδεικνύεται ότι πρόκειται για έναν πολυμελή αγιογραφικό οίκο με ποικίλες παραλλαγές στη σύνθεσή του που χάρις κυρίως στην εξαιρετικά εκτεταμένη κτητορική δραστηριότητα του Σέρβου κράλη Στέφανου Ούρεση B΄ Μιλούτιν, άφησε πίσω του το μεγαλύτερο έως σήμερα γνωστό ενυπόγραφο σύνολο μνημειακής ζωγραφικής στο Βυζάντιο και τη σφαίρα επιρροής του.
Αξιολόγηση της παρουσίας ραδιονουκλιδίων και τοξικών ρύπων στην εγγύς περιοχή μονάδων επεξεργασίας πετρελαίου
Authors: Τσάμος Παναγιώτης
Published: July 2022

Το πετρέλαιο, είναι ένα ορυκτό καύσιμο μαζικής κατανάλωσης και συμπεριλαμβάνεται στα υλικά που εκπέμπουν φυσική ραδιενέργεια. Κατά τις διαδικασίες της επεξεργασίας-διύλισης και της καύσης του, απελευθερώνει στην ατμόσφαιρα ένα μεγάλο ποσοστό επικίνδυνων στοιχείων και ενώσεων μεταξύ των οποίων βαρέα μέταλλα και ραδιονουκλίδια, μέσω των αερίων που εκλύονται και της τέφρας που σχηματίζεται. Σκοπός της εργασίας αυτής ήταν η διερεύνηση της επιβάρυνσης που προκαλείται στο περιβάλλον από τη συνεχόμενη λειτουργία των διυλιστηρίων ΕΛΠΕ (Ελληνικά Πετρέλαια) και Καβάλα Oil που δραστηριοποιούνται σε δύο περιοχές στη Βόρεια Ελλάδα, Θεσσαλονίκη και Καβάλα αντίστοιχα.Η διερεύνηση επικεντρώθηκε στην παρουσία ραδιονουκλιδίων και βαρέων μετάλλων σε περιοχές πλησίον των εγκαταστάσεων πετρελαίου. Μελετήθηκε η χωρική και τοπική διασπορά ρύπων σε διάφορα είδη δειγμάτων. Στην περίπτωση της ΕΛΠΕ (Θεσσαλονίκη) τα δείγματα που μελετήθηκαν περιελάμβαναν επιφανειακό έδαφος, υγρές κατακρημνίσεις (χιόνι-βροχή) και φυλώδη λαχανικά. Αντίστοιχα για την περιοχή της Καβάλας, τα δείγματα αφορούσαν άμμο, θαλάσσια ιζήματα, θαλάσσια ύδατα και φυτικούς ιστούς-φύκια.Η φασματοσκοπία ακτινών-γ εφαρμόστηκε για τον προσδιορισμό της συγκέντρωσης των διαφόρων ραδιονουκλιδίων (ενεργότητες των ραδιονουκλιδίων U-238, Τh-232 και Ra-226, αλλά και των Cs-137 και K-40) και η φασματοσκοπία ακτινών-α για τον προσδιορισμό της συγκέντρωσης του ουρανίου και της ισοτοπικής σχέσης των φυσικών ισοτόπων του και συγκεκριμένα του λόγου U-234 προς το U-238. Η συγκέντρωση των βαρέων μετάλλων και των ιχνοστοιχείων (όπως As, Cd, Cr, Cu, Fe, Mn, Ni, Pb και Zn) στα υπό μελέτη δείγματα πραγματοποιήθηκε με διάφορες τεχνικές όπως φασματοσκοπία με επαγωγικά συζευγμένο πλάσμα (ICP-MS και ICP-OES), φθορισμό με ακτίνες-Χ (ED-XRF) και πολαρογραφία. Η μελέτη αυτή θα συνεισφέρει στην εκτίμηση της περιβαλλοντικής ρύπανσης που προκαλείται τόσο από ραδιονουκλίδια όσο και από βαρέα μέταλλα σε περιοχές ανάλογες με τις περιοχές που μελετήθηκαν και συνεπώς στη λήψη των απαιτούμενων μέτρων για την προστασία του κοινού και του περιβάλλοντος.
The debate on distributive justice revisited: The political philosophy and the economic perspectives on economic (in)equality
Authors: Ivanov Denis
Published: July 2022

This paper reviews the broad literature on the concept of socio-economic inequality. It presents the debate between political philosophers and economists from an economic history perspective. In political philosophy, the concept of distributive justice is a normative principle which is closely related (although not identical) to economic inequality or income distribution in economics (and political economy). Originating in the 17th century, the study traces the evolution of the debate between egalitarianists and utilitarians to the modern times. It then continues to propose the alternative theories of capabilities and a reconciliatory theory of inequality of opportunity, reviewing a total of eight theories. Moreover, it continues to review the side of the debate from the economic perspective, exploring 12 theories ranging from Malthusian cycles to global inequality, the institutional perspective, economic insecurity, income polarization, and others. The debate concludes that, while economic theories are almost exclusively utilitarian and positive (as opposed to normative economics), political philosophy theories mostly contain normative aspects and are concerned with what is fair, which is not suitable for cross-national and time-variant research.
Fertility-sparing treatment of endometrial cancer - is it possible? A case study
Authors: Leziak Milena , Żak Klaudia , Satora Małgorzata , Szpyra Justyna , Kluz Natalia , Kułak Krzysztof
Published: July 2022

Background: Endometrial cancer is the most common gynecological malignant neoplasm, which occurs in the majority of cases postmenopausally. The current standard of treatment is surgical - total hysterectomy.  However, it may also occur in younger patients, who are planning pregnancy and want to choose fertility-sparing treatment. For those patients oral high dose progestin therapy with or without hysteroscopic resection should be proposed. It is usually a good option for women with well-differentiated (G1) cancers. For patients with higher grade (G2, G3) or contraindications to progestins, fertility-sparing treatment of endometrial cancer seems impossible.

Case report: We present the case of a 34-year old woman diagnosed gynecologically due to abnormal bleeding from the genital tract. Based on USG, she was diagnosed with endometrial polyp. As a treatment, hysteroscopic resection was performed. In the histopathological evaluation G2 endometrial cancer was diagnosed. The standard approach would be a total hysterectomy, but the patient was interested in fertility-sparing options. Due to contraindications to progestins a total hysteroscopic resection was performed counseling the patient about the risks of a novel approach. Histopathology revealed no residual disease and no other lesions during the first year of observations occurred.

Conclusion: Total hysteroscopic resection without further progestin therapy may offer the possibility to treat G2 endometrial cancer despite contraindications to the administration of progestins. Our case report should also encourage further evaluation of fertility-sparing management of endometrial cancer with higher than G1 grade.
Finite-Sample Guarantees for Wasserstein Distributionally Robust Optimization: Breaking the Curse of Dimensionality
Authors: Gao Rui
Published: July 2022

Wasserstein distributionally robust optimization is a recent emerging modeling paradigm for decision making under data uncertainty. Because of its computational tractability and interpretability, it has achieved great empirical successes across several application domains in operations research, computer science, engineering, and business analytics. Despite its recent empirical success, existing performance guarantees for generic problems are not yet satisfactory. In this paper, we develop the first finite-sample guarantee without suffering from the curse of dimensionality, which describes how the out-of-sample performance of a robust solution depends on the sample size, dimension of the uncertainty, and the complexity of the loss function class in a nearly optimal way.
Motivational Methods of Teaching Fitness Aerobics Exercises in Physical Education Lessons for High School Students
Authors:   MI ", Shkola Olena ,   Kharkiv Humanitarian and Pedagogical Academy",   of the Kharkiv Regional Council, Zhamardiy Valerii ,   Poltava State Medical University
Published: July 2022

One of the effective forms of ensuring the formation of positive interest in students, motivation to engage in physical culture, development of physical qualities, health promotion is fitness aerobics. To develop a method of using fitness aerobics in physical education classes as a tool for forming motivation for high school girls to exercise. Methodology research is based on scientific principles set forth in the works of famous teachers, coaches, psychologists, specialists in physical culture and sports, physical education and physical training; specialists in the theory and methods of development of motor skills; modern specialists in the field of aerobic technologies; specialists in medical and biological foundations of health physical culture. Scientific novelty is that the method of using fitness aerobics in the lessons of physical culture of high school students is theoretically substantiated and developed; improved the content of independent classes planned in the educational process of physical culture, which were used as an additional reserve for motivation and development of physical qualities of girls, increase their weekly physical activity and laid the foundation for personal organization of independent classes; added data on the use of fitness aerobics to increase the level of physical fitness of high school students and motivation to exercise. In order to determine the impact of our methodology aimed at improving physical education lessons and motivation for the classes themselves, a re-study was conducted during the formative part of the experiment. The results of this study show that the number of girls who regularly started attending physical education classes increased by 20 % to 88%. It is also important to note that after the introduction of aerobics in physical education classes, the number of students who began to enjoy physical education lessons increased to 96 %, while before the introduction of the method, their number was 84%.
Cultural Competence Formation of Secondary School Students by the Means of Physical Education
Authors:   State Institution Luhansk Taras Shevchenko National University, Kurlishсhuk Inna , Aleksieiеva Oksana ,   State Institution Luhansk Taras Shevchenko National University
Published: July 2022

The article raises the issue of cultural competence formation of secondary school students by the means of physical education in curricular and co-curricular activities that are an integral part of the over-all instructional school programme. The authors determine that in the context of reformation changes of Ukrainian education system the modern educational space of general secondary education institutions becomes a platform for cultural diversity and pluralism as well as for socialization and democratic national self-determination of secondary school students. It is noted that physical education exposes the secondary school students to a range of experiences that enable them to develop the skills and knowledge they need to make the most of all opportunities today and to shape new forms of global culture. The concept of «cultural competence» is regarded as the formation of skills to present the native culture in modern multicultural environment, the capacity and willingness to participate in the dialogue of cultures and the assimilation of the national and cultural component as a basic condition for familiarizing to the culture of their own country. The authors found that it is essential to approach the development of secondary school students’ cultural competence through the means of physical culture and sports as the keynote elements. It is obvious that physical education is able to increase the motivation of students for studying of Ukrainian culture and traditions that will enhance to the quality of their knowledge in this sphere and the level of their cultural competence.
Taking Into Account the Peculiarities of the Female Body in Physical Education Lessons with Teenage Girls
Authors:   Sumy Makarenko State Pedagogical University, Loza Tetiana
Published: July 2022

The aim is to investigate the peculiarities of the level of manifestation of motor abilities of adolescent girls in physical education lessons, taking into account the peculiarities of the female body. The study involved 28 girls aged 14-15 with the consent of their parents, who helped fill in the data in the diary. The article considers the problem of improving the physical fitness of adolescent girls in physical education classes, taking into account the characteristics of the female body. Certain days of the menstrual cycle are favorable for the development of physical qualities. The study of the level of manifestation of different indicators of motor abilities on different days of the menstrual cycle of girls showed that they are heterochronous. This heterochrony affects the efficiency of the process of development of physical qualities. Therefore, favorable days of the menstrual cycle to learn new motor skills and increase the level of physical fitness are the days when the indicators under study are at a high level. These days are: 5-11 and 16-24 days of the ovarian – menstrual cycle (CMC). We investigated that the high level of manifestation of speed and strength abilities of girls was in 4-12, 16-25 days, average in 3, 15, 26, 27 days, low in 1, 2, 13, 14, 28 days of CMC. Studies have shown that the functional stability of the vestibular apparatus from 3 to 25 days of the menstrual cycle was at a high level, on the 2nd day of the cycle was an average level of manifestation, and on 1, 26, 27, 28 days - a low level. Manifestation of coordination abilities was characterized by a high level of 5-11, 15-24 days, medium - 3, 4, 12, 25, 26 days, low – 1, 2, 13, 14, 27, 28 days of the cycle. The state of special endurance in girls was characterized by a high level of manifestation in 5-11, 16-24 days, medium – in 3, 4, 15, 25 days, low – in 1, 2, 13, 14, 26, 27, 28 days of the cycle. Determination of flexibility in girls was characterized by a high level of manifestation in 1-12, 15-26 days of the cycle and an average in 13-14, 27, 28 days. Studies have shown that the selection of tools and methods used in classes with adolescent girls should take into account the sexual characteristics of students. These studies should be used in the educational process of adolescent girls in learning new motor skills and abilities, taking into account the days of the menstrual cycle to improve their health and increase their physical fitness. Given the individual functional state, changes in health in connection with the CMC, there is an opportunity and need to plan the load in the educational process, adjusting the volume and intensity of physical education lessons with girls.
Features of Studying and Forming a Positive Psychological Climate of a Sports Team
Authors:   National University ", Onishchuk Larysa ,   Yuri Kondratyuk Poltava Polytechnic"
Published: July 2022

The article is devoted to the study of the problem of studying and forming a positive psychological climate of the sports team, which is one of the main factors in achieving high sports results. The aim of the article is to analyze the scientific and methodological literature on the problem of research and identify components that affect the formation of the psychological climate of the sports team, as well as methods and techniques of research on this issue. one of the possible ways to diagnose interpersonal relationships is to identify those individual qualities and properties that affect the relationship itself. The verbal scales we used to identify one or another property confirmed that high sports results are due to the favorable psychological climate in the team and a high degree of compatibility of its members. We considered the compatibility of members of the sports team on three levels: social, psychological and psychophysiological. In the process of each, including sports activities, relationships, traditions, habits, feelings are established between people, which directly or indirectly affect its effectiveness. These processes are called the psychological climate, which is formed in sports under the influence of various objective and subjective factors: success, age, feelings, moods, motives, needs and relationships between athletes, as well as under the influence of purposeful pedagogical work of the coach. The sphere of interpersonal relationships in a sports team is extremely wide, they have a complex structure, permeate different levels of organization of personality. Therefore, with the help of one, even well-designed test, it is impossible to fully reveal human relationships. Here it is necessary to use a comprehensive analysis of the individual and the team as a whole. The demand of society for attention to the psychological comfort of being in a professional environment is extremely high.
Research of Physical Activity of Students in the Conditions of Distance Learning and Self-Isolation
Authors:   State Institution Luhansk Taras Shevchenko National University, Berezueva Tetiana
Published: July 2022

Against the background of reforming the education system, which is characterized by the fastest pace, today one of the most acute, difficult to solve is the problem of improving the physical education system. Higher education institutions during distance learning, such as the pandemic period, are considering ways to address the physical activity of students. An important aspect of research in the field of increasing physical activity is to find ways to improve the organization of physical education of student youth. Due to their age characteristics, young students feel the need for physical activity, active recreation, outdoor activities. Fascination with various sports, fitness, dancing, yoga and other physical activities form a full development of the body of applicants for education. Exercise has a positive effect on the brain, helping it to balance nervous processes, as impulses from working muscles are transmitted to the internal systems of organs. Young people who lead an active lifestyle, attend various sports sections, and also have academic achievements. She is focused, communicative, responsible, able to solve problems quickly, her body adapts more quickly to mental and physical stress, less prone to stress.
Analysis of the Current State of Quality Management Training of Future Specialists in Physical Culture and Sports in Higher Education Institutions
Authors:   State Institution Luhansk Taras Shevchenko National University, Hadyuchko Oleksandr
Published: July 2022

The scientific work is devoted to the study of the current state of quality management of higher education in sports institutions, as one of the most important components of the management system in the training of professionals in the field of physical culture and sports in higher education. The aim of the article is to analyze the scientific and methodological achievements of Ukrainian and today`s foreign prominent scientists on the problem of the current state of quality management training of future specialists in physical culture and sports in higher education. Also, we conducted a study (survey) – attitudes, wishes, pros and cons of distance learning during the quarantine restrictions of higher education. The second part of our study concerned the physical activity of higher education seekers. We also heard from higher education students the wishes, suggestions and shortcomings of various forms of distance learning in the Free Economic Zone. with some exceptions (the applicant is at a training meeting to prepare for important national, European or world competitions or works in the specialty, also due to quarantine restrictions).
Formation of Professional Ethics of Future Hospitality Professionals
Authors:   Vasyl Stefanyk Precarpathian National University, Zagnibida Raisa
Published: July 2022

The main approaches to the problem of formation of professional ethics of future hospitality specialists are determined and analyzed. The article describes the specifics and system of requirements for professional ethics of hospitality specialists. The main problems and some norms of professional ethics are highlighted, the requirements to personal and professionally significant qualities of hospitality specialists are formulated. The general characteristic of ethical behavior of the expert is given.
Analysis of Psychophysiological Features of Operator Behavior in Extreme Situations
Authors:   Khmelnytskyi Institute of Social Technologies, Lutskevich Nataliia
Published: July 2022

The article analyzes the psychophysiological features of the operator's behavior in extreme conditions and situations. The author determined that extreme conditions are somewhat different from extreme situations. If extreme conditions can be identified with «critical» circumstances that change little in time, then extreme situations develop in a short period of time and are characterized by sharp dynamic changes in circumstances. In general, the influence of extreme factors, conditions, situations leads to the emergence of a stressful situation in the body of the operator. Stress – a state of mental stress that occurs in the process of activity in the most difficult and difficult – extreme conditions. In the conclusions of the article, the researcher noted that the behavior of the operator in extreme conditions and situations is characterized by stress, the impact of which is manifested depending on the subjective characteristics of psychophysiological qualities of the operator. Most of them are clearly clearly affected at once. Some, on the contrary, encourage more productive activities. But, in the end, the impact of extreme factors is clearly negative.
Identifying the Level of Professional Abilities of Future Coaches in Ukrainian Higher Education Institutions
Authors:   State Institution Luhansk Taras Shevchenko National University, Omelchenko Alina
Published: July 2022

The article is devoted to the research of the problem of professional training of future trainers in Ukrainian higher education institutions. The article examines the level of professional abilities of higher education students who study 3-4 courses at the Educational and Scientific Institute of Physical Education and Sports of the State Institution «Lugansk National University named after Taras Shevchenko» majoring in Physical Culture and Sports. The coach is the main link in the process of training athletes. In high-achievement sports, children spend most of their time in the gym, devoting little time to socializing with friends and family. It is the coach who becomes the child's mentor, educator, friend, and sometimes even an idol. Therefore, not only the athlete's sports result, but also his worldview always depends on the coach. Therefore, the coach has a great responsibility for the Ukrainian youth and it is very important that the coach has the professional knowledge, skills and abilities necessary for his professional activity. Today in Ukraine there are special higher education institutions that train future coaches. The Educational and Scientific Institute of Physical Education and Sports of the Taras Shevchenko Luhansk National University is one of them. In order to identify the level of professional abilities of applicants for higher education, we conducted a series of tests, which were divided into three groups. In each group there were tasks for different knowledge, skills and abilities of the future coach. The study involved 64 applicants for higher education, who studied in 3-4 courses of the Department of Olympic and Professional Sports. All tasks were performed by future coaches during sports and pedagogical improvement classes. Classes were held 2-3 times a week.
Formation of academic integrity of future social workers in the conditions of higher education institution
Authors:   Khmelnytskyi Institute of Social Technologies of University ", Ostrovska Nataliia ,   Ukraine", Dobrovitska Olena ,   Khmelnytskyi Institute of Social Technologies of University "Ukraine"
Published: July 2022

The article analyzes the process of formation of academic integrity of future social workers in a higher education institution on the example of the Khmelnytsky Institute of Social Technologies of the University «Ukraine». The authors determined that the issue of forming the academic integrity of future social workers deserves special attention, as their professional activities must meet the requirements of the Code of Ethics for Social Workers, which puts before the future specialist higher requirements for moral and cultural values. The purpose, basic principles and types of violation of academic integrity are considered (according to Ukrainian legislation); the practice of formation of academic integrity of future social workers of Khmelnytsky Institute of Social Technologies of Ukraine University is revealed, the main directions of which are: conducting educational activities with freshmen, acquainting higher education students with the Code of Academic Integrity, signing the Declaration on Academic Integrity of Students, inclusion of certain topics on the formation of academic integrity in subjects, educational activities among graduates, passing coursework and qualifications through a plagiarism check program.