bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S3 from Phase I Dose-Escalation and -Expansion Study of Telisotuzumab (ABT-700), an Anti–c-Met Antibody, in Patients with Advanced Solid Tumors
Authors: Strickler John H. , LoRusso Patricia , Salgia Ravi , Kang Yoon-Koo , Yen Chia Jui , Lin Chia-Chi , Ansell Peter , Motwani Monica , Wong Shekman , Yue Huibin , Wang Lan , Reilly Edward , Afar Daniel , Naumovski Louie , Ramanathan Ramesh K.
Published: April 2023

FISH analysis or ctDNA analysis for MET amplification was performed on enrolled patients (N=45).
Supplementary Figure 4 from 10D1F, an Anti-HER3 Antibody That Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models
Authors: Thakkar Dipti , Sancenon Vicente , Taguiam Marvin M. , Guan Siyu , Wu Zhihao , Ng Eric , Paszkiewicz Konrad H. , Ingram Piers J. , Boyd-Kirkup Jerome D.
Published: April 2023

10D1F does not show rapid internalization in HER3 expressing cancer cell lines but activates ADCC
Supplementary Table 1 from Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK
Authors: Pucciarelli Daniela , Angus Steven P. , Huang Benjamin , Zhang Chi , Nakaoka Hiroki J. , Krishnamurthi Ganesh , Bandyopadhyay Sourav , Clapp D. Wade , Shannon Kevin , Johnson Gary L. , Nakamura Jean L.
Published: April 2023

Supplementary Table 1
Fig. S5 from Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK
Authors: Pucciarelli Daniela , Angus Steven P. , Huang Benjamin , Zhang Chi , Nakaoka Hiroki J. , Krishnamurthi Ganesh , Bandyopadhyay Sourav , Clapp D. Wade , Shannon Kevin , Johnson Gary L. , Nakamura Jean L.
Published: April 2023

Supplementary Figure 5
Video D from Preclinical Development of MGC018, a Duocarmycin-based Antibody–drug Conjugate Targeting B7-H3 for Solid Cancer
Authors: Scribner Juniper A. , Brown Jennifer G. , Son Thomas , Chiechi Michael , Li Pam , Sharma Sharad , Li Hua , De Costa Anushka , Li Ying , Chen Yan , Easton Ann , Yee-Toy Nicholas C. , Chen Francine Z. , Gorlatov Sergey , Barat Bhaswati , Huang Ling , Wolff Christina R. , Hooley Jeff , Hotaling Tim E. , Gaynutdinov Timur , Ciccarone Valentina , Tamura James , Koenig Scott , Moore Paul A. , Bonvini Ezio , Loo Deryk
Published: April 2023

5000 Hs700T B7-H3 KO/RFP cells alone in the presence of 6.7 nM MGC018
Supplementary Table 1 from Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade
Authors: Alexander Eric T. , Mariner Kelsey , Donnelly Julia , Phanstiel Otto , Gilmour Susan K.
Published: April 2023

Supplementary Table 1
Supplemental Figure 4 from Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Authors: Shaw Jeremy J.P. , Boyer Timothy L. , Venner Emily , Beck Patrick J. , Slamowitz Tristen , Caste Tara , Hickman Alexandra , Raymond Michael H. , Costa-Pinheiro Pedro , Jameson Mark J. , Fox Todd E. , Kester Mark
Published: April 2023

Methylpyruvate Rescues from CNL+CQ-driven Oxidative Stress and Mitochondrial Function in UNC-10 Cells
Figure S4 from On-Target Pharmacodynamic Activity of the PI3K Inhibitor Copanlisib in Paired Biopsies from Patients with Malignant Lymphoma and Advanced Solid Tumors
Authors: Morschhauser Franck , Machiels Jean-Pascal , Salles Gilles , Rottey Sylvie , Rule Simon A.J. , Cunningham David , Peyrade Frederic , Fruchart Christophe , Arkenau Hendrik-Tobias , Genvresse Isabelle , Liu Li , Köchert Karl , Shen Kui , Kneip Christoph , Peña Carol E. , Grevel Joachim , Zhang Jun , Cisternas Galia , Reschke Susanne , Granvil Camille , Awada Ahmad
Published: April 2023

shows the correlation between different PK parameters and percentage change in tumor size from baseline
Supplementary Movie M3 from Amivantamab (JNJ-61186372), an Fc Enhanced EGFR/cMet Bispecific Antibody, Induces Receptor Downmodulation and Antitumor Activity by Monocyte/Macrophage Trogocytosis
Authors: Vijayaraghavan Smruthi , Lipfert Lorraine , Chevalier Kristen , Bushey Barbara S. , Henley Benjamin , Lenhart Ryan , Sendecki Jocelyn , Beqiri Marilda , Millar Hillary J. , Packman Kathryn , Lorenzi Matthew V. , Laquerre Sylvie , Moores Sheri L.
Published: April 2023

Live cell imaging of M2 macrophage mediated trogocytosis
Supplementary Movie M1 from Amivantamab (JNJ-61186372), an Fc Enhanced EGFR/cMet Bispecific Antibody, Induces Receptor Downmodulation and Antitumor Activity by Monocyte/Macrophage Trogocytosis
Authors: Vijayaraghavan Smruthi , Lipfert Lorraine , Chevalier Kristen , Bushey Barbara S. , Henley Benjamin , Lenhart Ryan , Sendecki Jocelyn , Beqiri Marilda , Millar Hillary J. , Packman Kathryn , Lorenzi Matthew V. , Laquerre Sylvie , Moores Sheri L.
Published: April 2023

Live cell imaging of monocyte mediated trogocytosis
Supplementary Tables from A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
Authors: Yang Zhenyu , Wang Dan , Johnson James K. , Pascal Laura E. , Takubo Keita , Avula Raghunandan , Chakka Anish Bhaswanth , Zhou Jianhua , Chen Wei , Zhong Mingming , Song Qiong , Ding Hui , Wu Zeyu , Chandran Uma R. , Maskrey Taber S. , Nelson Joel B. , Wipf Peter , Wang Zhou
Published: April 2023

Supplementary Tables S1-S4
Supplementary Methods from Toxicology and Pharmacokinetic Studies in Mice and Nonhuman Primates of the Nontoxic, Efficient, Targeted Hexameric FasL: CTLA4-FasL
Authors: Makdasi Efi , Amsili Shira , Aronin Alexandra , Prigozhina Tatyana B. , Tzdaka Kobi , Gozlan Yosi Meir , Ben Gigi–Tamir Liat , Sagiv Jitka Yehudith , Shkedy Fanny , Shani Noam , Tykocinski Mark L. , Dranitzki Elhalel Michal
Published: April 2023

Supplementary Methods
Supplementary Figure S6 from High-Throughput Generation of Bispecific Binding Proteins by Sortase A–Mediated Coupling for Direct Functional Screening in Cell Culture
Authors: Andres Fabio , Schwill Martin , Boersma Ykelien L. , Plückthun Andreas
Published: April 2023

Receptor crosslinking and proliferation assay of SKBR3 cells after treatment
Supplementary Figure S4 from High-Throughput Generation of Bispecific Binding Proteins by Sortase A–Mediated Coupling for Direct Functional Screening in Cell Culture
Authors: Andres Fabio , Schwill Martin , Boersma Ykelien L. , Plückthun Andreas
Published: April 2023

SDS-PAGE of 28 random samples from 441 parallel wtSrtAmediated coupling reactions
Supplementary Data from A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate
Authors: Akbulut Ozge , Lengerli Deniz , Saatci Ozge , Duman Elif , Seker Urartu O.S. , Isik Aynur , Akyol Aytekin , Caliskan Burcu , Banoglu Erden , Sahin Ozgur
Published: April 2023

Supplementary Methods
Supplementary Figure S2 from High-Throughput Generation of Bispecific Binding Proteins by Sortase A–Mediated Coupling for Direct Functional Screening in Cell Culture
Authors: Andres Fabio , Schwill Martin , Boersma Ykelien L. , Plückthun Andreas
Published: April 2023

Characterization of DARPin C7x
Figure S4 from A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate
Authors: Akbulut Ozge , Lengerli Deniz , Saatci Ozge , Duman Elif , Seker Urartu O.S. , Isik Aynur , Akyol Aytekin , Caliskan Burcu , Banoglu Erden , Sahin Ozgur
Published: April 2023

TACC3 inhibition induces mitotic arrest, DNA damage and apoptosis in cell lines responsive to BO-264.
Figure S5 from Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist
Authors: García-Martínez Juan Manuel , Wang Shirley , Weishaeupl Cordula , Wernitznig Andreas , Chetta Paolo , Pinto Catarina , Ho Jason , Dutcher Darrin , Gorman Philip N. , Kroe-Barrett Rachel , Rinnenthal Joerg , Giragossian Craig , Impagnatiello Maria Antonietta , Tirapu Iñigo , Hilberg Frank , Kraut Norbert , Pearson Mark , Kuenkele Klaus Peter
Published: April 2023

Impact of CDH17 targeting on bi-specific molecules in vivo efficacy.
Figure S1 from Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist
Authors: García-Martínez Juan Manuel , Wang Shirley , Weishaeupl Cordula , Wernitznig Andreas , Chetta Paolo , Pinto Catarina , Ho Jason , Dutcher Darrin , Gorman Philip N. , Kroe-Barrett Rachel , Rinnenthal Joerg , Giragossian Craig , Impagnatiello Maria Antonietta , Tirapu Iñigo , Hilberg Frank , Kraut Norbert , Pearson Mark , Kuenkele Klaus Peter
Published: April 2023

TRAILR2 and CDH17 RNA expression in related normal tissues.
Supplementary Table 1 from Exosomal Noncoding RNAs in Hepatobiliary Cancer: A Rising Star
Authors: Zheng Wangyang , Ji Daolin , Zhou Yongxu , Yu Liang , Huang Peng , Zheng Yuling , Meng Nanfeng , Wang Hang , Bai Xue , Huang ZiYue , Chen Wangming , Yam Judy W.P. , Xu Yi , Cui Yunfu
Published: April 2023

Supplementary Table 1: Exosomal ncRNAs involved in cell-to-cell communication in cholangiocarcinoma (CCA)
Supplementary Data from Leflunomide Suppresses the Growth of LKB1-Inactivated Tumors in the Immune-Competent Host and Attenuates Distant Cancer Metastasis
Authors: Jin Rui , Liu Boxuan , Liu Xiuju , Fan Yijian , Peng Wei , Huang Chunzi , Marcus Adam , Sica Gabriel , Gilbert-Ross Melissa , Liu Yuan , Zhou Wei
Published: April 2023

Supplemental Figures and Tables
Supplementary Data from PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways
Authors: Su Shengqin , Chhabra Gagan , Ndiaye Mary A. , Singh Chandra K. , Ye Ting , Huang Wei , Dewey Colin N. , Setaluri Vijayasaradhi , Ahmad Nihal
Published: April 2023

Supplementary files to support the manuscript, including antibody and cell line mutational information and confirmation/setup information for different experiments.
Figure S1 from Gefitinib Inhibits Invasion and Metastasis of Osteosarcoma via Inhibition of Macrophage Receptor Interacting Serine-Threonine Kinase 2
Authors: Maloney Caroline , Kallis Michelle P. , Edelman Morris , Tzanavaris Christopher , Lesser Martin , Soffer Samuel Z. , Symons Marc , Steinberg Bettie M.
Published: April 2023

Figure S1 shows the reduction in pulmonary macrophages with inhaled clodronate.
Table S4 from Identification of ALDH1A3 as a Viable Therapeutic Target in Breast Cancer Metastasis–Initiating Cells
Authors: Yamashita Daisuke , Minata Mutsuko , Ibrahim Ahmed N. , Yamaguchi Shinobu , Coviello Vito , Bernstock Joshua D. , Harada Shuko , Cerione Richard A. , Tannous Bakhos A. , La Motta Concettina , Nakano Ichiro
Published: April 2023

RNA sequence data in 373 EMT-representative genes
Supplementary Data from Potent Synergistic Effect on C-Myc–Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor
Authors: Xie Yanqi , Zhang Wen , Guo Lichao , Kril Liliia M. , Begley Kristin L. , Sviripa Vitaliy M. , Chen Xi , Liu Xifu , Lee Eun Y. , He Daheng , Wang Chi , Gao Tianyan , Liu Xiaoqi , Evers B. Mark , Watt David S. , Liu Chunming
Published: April 2023

Supplementary methods and figures
Table S1 from Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity
Authors: Ho Sun K. , Xu Zhenghai , Thakur Archana , Fox Melvin , Tan Siu Sze , DiGiammarino Enrico , Zhou Li , Sho Mien , Cairns Belinda , Zhao Vivian , Xiong Mengli , Samayoa Josue , Forsyth Charles M. , Powers David B. , Chao Debra T. , Hollenbaugh Diane , Alvarez Hamsell M. , Akamatsu Yoshiko
Published: April 2023

Binding kinetics of anti-CD137 measured by Biacore
Supplementary Figure 4 from Identification of ALDH1A3 as a Viable Therapeutic Target in Breast Cancer Metastasis–Initiating Cells
Authors: Yamashita Daisuke , Minata Mutsuko , Ibrahim Ahmed N. , Yamaguchi Shinobu , Coviello Vito , Bernstock Joshua D. , Harada Shuko , Cerione Richard A. , Tannous Bakhos A. , La Motta Concettina , Nakano Ichiro
Published: April 2023

Elevation of ALDH1A3 expression in BM tissues and cells
Figure S3 from Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity
Authors: Ho Sun K. , Xu Zhenghai , Thakur Archana , Fox Melvin , Tan Siu Sze , DiGiammarino Enrico , Zhou Li , Sho Mien , Cairns Belinda , Zhao Vivian , Xiong Mengli , Samayoa Josue , Forsyth Charles M. , Powers David B. , Chao Debra T. , Hollenbaugh Diane , Alvarez Hamsell M. , Akamatsu Yoshiko
Published: April 2023

Liver toxicity measured by serum ALT level
Figure S1 from Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity
Authors: Ho Sun K. , Xu Zhenghai , Thakur Archana , Fox Melvin , Tan Siu Sze , DiGiammarino Enrico , Zhou Li , Sho Mien , Cairns Belinda , Zhao Vivian , Xiong Mengli , Samayoa Josue , Forsyth Charles M. , Powers David B. , Chao Debra T. , Hollenbaugh Diane , Alvarez Hamsell M. , Akamatsu Yoshiko
Published: April 2023

Simultaneous binding shown in Biacore sensorgrams
Supplementary Data from Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma
Authors: Reddy Gireesh B. , Kerr David L. , Spasojevic Ivan , Tovmasyan Artak , Hsu David S. , Brigman Brian E. , Somarelli Jason A. , Needham David , Eward William C.
Published: April 2023

Supplementary Materials including Text and Data
Supplementary Data from Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription
Authors: Liu Lixia , Deng Yaotang , Zheng Zhenming , Deng Zihao , Zhang Jinxin , Li Jieyou , Liang Manfeng , Zhou Xueqiong , Tan Wenchong , Yang Hongjun , Neckers Leonard M. , Zou Fei , Chen Xuemei
Published: April 2023

Supplementary Data
Figure S1, Table S1, Table S2, Table S3, Table S4, Table S5, Table S6 from Prognostic and Predictive Biomarkers in Patients with Metastatic Colorectal Cancer Receiving Regorafenib
Authors: Liu Yingmiao , Lyu Jing , Bell Burdett Kirsten , Sibley Alexander B. , Hatch Ace J. , Starr Mark D. , Brady John C. , Hammond Kelli , Marmorino Federica , Rossini Daniele , Goldberg Richard M. , Falcone Alfredo , Cremolini Chiara , Owzar Kouros , Ivanova Anastasia , Moore Dominic T. , Lee Michael S. , Sanoff Hanna K. , Innocenti Federico , Nixon Andrew B.
Published: April 2023

Figure S1, consort diagram. Table S1, pts characteristics. Table S2, baseline levels. Table S3, prognostic markers. Table S4, adjusted prognostic markers. Table S5, early changes. Table S6, late changes at disease progression.
Supplementary Data from SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models
Authors: Shomali Maysoun , Cheng Jane , Sun Fangxian , Koundinya Malvika , Guo Zhuyan , Hebert Andrew T. , McManus Jessica , Levit Mikhail N. , Hoffmann Dietmar , Courjaud Albane , Arrebola Rosalia , Cao Hui , Pollard Jack , Lee Joon Sang , Besret Laurent , Caron Anne , Bangari Dinesh S. , Abecassis Pierre-Yves , Schio Laurent , El-Ahmad Youssef , Halley Frank , Tabart Michel , Certal Victor , Thompson Fabienne , McCort Gary , Filoche-Rommé Bruno , Cheng Hong , Garcia-Echeverria Carlos , Debussche Laurent , Bouaboula Monsif
Published: April 2023

supplemental methods, data and figures
Figure S1 from Molecular Characterization of Appendiceal Goblet Cell Carcinoid
Authors: Arai Hiroyuki , Baca Yasmine , Battaglin Francesca , Kawanishi Natsuko , Wang Jingyuan , Soni Shivani , Zhang Wu , Millstein Joshua , Johnston Curtis , Goldberg Richard M. , Philip Philip A. , Seeber Andreas , Xiu Joanne , Hwang Jimmy J. , Shields Anthony F. , Marshall John L. , Korn W. Michael , Lenz Heinz-Josef
Published: April 2023

TNM staging summary
Supplementary Table S3 from Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor
Authors: García-Valverde Alfonso , Rosell Jordi , Serna Garazi , Valverde Claudia , Carles Joan , Nuciforo Paolo , Fletcher Jonathan A. , Arribas Joaquín , Politz Oliver , Serrano César
Published: April 2023

IC50 values (nM) obtained from cell viability studies.
Supplementary Figure S4 from Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor
Authors: García-Valverde Alfonso , Rosell Jordi , Serna Garazi , Valverde Claudia , Carles Joan , Nuciforo Paolo , Fletcher Jonathan A. , Arribas Joaquín , Politz Oliver , Serrano César
Published: April 2023

Representative IHC figures across all treatment arms.
Figure S1 from The Dual Androgen Receptor and Glucocorticoid Receptor Antagonist CB-03-10 as Potential Treatment for Tumors that have Acquired GR-mediated Resistance to AR Blockade
Authors: Rosette Caridad , Agan Frances J. , Rosette Niccolette , Mazzetti Alessandro , Moro Luigi , Gerloni Mara
Published: April 2023

Caspase Activity in MDA-MB-231
Table S4 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

MS Identification of CA6 antigen
Table S3 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12
Authors: Lewis Nuruddeen D. , Sia Chang Ling , Kirwin Katherine , Haupt Sonya , Mahimkar Gauri , Zi Tong , Xu Ke , Dooley Kevin , Jang Su Chul , Choi Bryan , Boutin Adam , Grube Andrew , McCoy Christine , Sanchez-Salazar Jorge , Doherty Michael , Gaidukov Leonid , Estes Scott , Economides Kyriakos D. , Williams Douglas E. , Sathyanarayanan Sriram
Published: April 2023

Reagents and antibodies
Table S2 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

IHC detection in normal human tissues of MUC1 glycoprotein and CA6 glycotope
Table S1 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

MS Identification of CA6 antigen
Mat & Met S5 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

Glycotope analysis of CA6 antigen
Mat & Met S3 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

Internalization of huDS6-Alexa 488 into tumor cell lines
Mat & Met S1 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

SAR566658 preparation and general structure
Figure S2 from An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Authors: Nicolazzi Céline , Caron Anne , Tellier Alexia , Trombe Marc , Pinkas Jan , Payne Gillian , Carrez Chantal , Guérif Stéphane , Maguin Marie , Baffa Raffaele , Fassan Matteo , Adam Julien , Mangatal-Wade Lydie , Blanc Véronique
Published: April 2023

Representative photomicrographs of different patterns of CA6 staining
Supplementary Fig S4 from CHK1/2 Inhibitor Prexasertib Suppresses NOTCH Signaling and Enhances Cytotoxicity of Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma
Authors: Zeng Ling , Nikolaev Anatoly , Xing Chuan , Della Manna Deborah L. , Yang Eddy S.
Published: April 2023

Figure S4 shows a western blot analysis in UM-SCC6 and UM-SCC47 cells
Supplementary Fig S1 from CHK1/2 Inhibitor Prexasertib Suppresses NOTCH Signaling and Enhances Cytotoxicity of Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma
Authors: Zeng Ling , Nikolaev Anatoly , Xing Chuan , Della Manna Deborah L. , Yang Eddy S.
Published: April 2023

Figure S1 shows a dose response study with prexasertib in UM-SCC1, UM-SCC6, and UM-SCC47 HNSCC cell lines in proliferation assays.
Supplementary Data from CHK1/2 Inhibitor Prexasertib Suppresses NOTCH Signaling and Enhances Cytotoxicity of Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma
Authors: Zeng Ling , Nikolaev Anatoly , Xing Chuan , Della Manna Deborah L. , Yang Eddy S.
Published: April 2023

supplemental fig legends
Table S4 from PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers
Authors: Graziani Edmund I. , Sung Matthew , Ma Dangshe , Narayanan Bitha , Marquette Kimberly , Puthenveetil Sujiet , Tumey L. Nathan , Bikker Jack , Casavant Jeffrey , Bennett Eric M. , Charati Manoj B. , Golas Jonathon , Hosselet Christine , Rohde Cynthia M. , Hu George , Guffroy Magali , Falahatpisheh Hadi , Finkelstein Martin , Clark Tracey , Barletta Frank , Tchistiakova Lioudmila , Lucas Judy , Rosfjord Edward , Loganzo Frank , O'Donnell Christopher J. , Gerber Hans-Peter , Sapra Puja
Published: April 2023

Effects of a Conventional and a Site-Specific Conjugate Targeting HER2 on Indicators of Bone Marrow Toxicity and Serum ADC/Payload Exposures in Rats
Table S1 from PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers
Authors: Graziani Edmund I. , Sung Matthew , Ma Dangshe , Narayanan Bitha , Marquette Kimberly , Puthenveetil Sujiet , Tumey L. Nathan , Bikker Jack , Casavant Jeffrey , Bennett Eric M. , Charati Manoj B. , Golas Jonathon , Hosselet Christine , Rohde Cynthia M. , Hu George , Guffroy Magali , Falahatpisheh Hadi , Finkelstein Martin , Clark Tracey , Barletta Frank , Tchistiakova Lioudmila , Lucas Judy , Rosfjord Edward , Loganzo Frank , O'Donnell Christopher J. , Gerber Hans-Peter , Sapra Puja
Published: April 2023

ADC retention times by hydrophobic interaction chromatography (HIC).
Figure S2 from PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers
Authors: Graziani Edmund I. , Sung Matthew , Ma Dangshe , Narayanan Bitha , Marquette Kimberly , Puthenveetil Sujiet , Tumey L. Nathan , Bikker Jack , Casavant Jeffrey , Bennett Eric M. , Charati Manoj B. , Golas Jonathon , Hosselet Christine , Rohde Cynthia M. , Hu George , Guffroy Magali , Falahatpisheh Hadi , Finkelstein Martin , Clark Tracey , Barletta Frank , Tchistiakova Lioudmila , Lucas Judy , Rosfjord Edward , Loganzo Frank , O'Donnell Christopher J. , Gerber Hans-Peter , Sapra Puja
Published: April 2023

Immunohistochemical evaluation of HER2 expression in vivo cell line and patient-derived xenograft models.
Supplementary Appendix file from PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis
Authors: Lim James T. , Singh Neha , Leuvano Libia A. , Calvert Valerie S. , Petricoin Emanuel F. , Teachey David T. , Lock Richard B. , Padi Megha , Kraft Andrew S. , Padi Sathish K.R.
Published: April 2023

Supplementary Materials and Methods, Tables and References
Supplementary Tables 1-3 from A Novel Approach to Safer Glucocorticoid Receptor–Targeted Anti-lymphoma Therapy via REDD1 (Regulated in Development and DNA Damage 1) Inhibition
Authors: Lesovaya Ekaterina A. , Savinkova Alena V. , Morozova Olga V. , Lylova Evgeniya S. , Zhidkova Ekaterina M. , Kulikov Evgeny P. , Kirsanov Kirill I. , Klopot Anna , Baida Gleb , Yakubovskaya Marianna G. , Gordon Leo I. , Readhead Ben , Dudley Joel T. , Budunova Irina
Published: April 2023

Supplementary Tables 1-3. Suppl. Table 1 contains the list of REDD1 inhibitors identified by computational screen and selected for study. Suppl. Table 2 contains primer sets for Q-PCR analysis. Suppl. Table 3 contains IC50 values of WM, LY294002 and AZD8055 after 24 h of incubation.
Supplementary Data from PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus
Authors: Mpilla Gabriel B. , Uddin Md. Hafiz , Al-Hallak Mohammed N. , Aboukameel Amro , Li Yiwei , Kim Steve H. , Beydoun Rafic , Dyson Gregory , Baloglu Erkan , Senapedis William T. , Landesman Yosef , Wagner Kay-Uwe , Viola Nerissa T. , El-Rayes Bassel F. , Philip Philip A. , Mohammad Ramzi M. , Azmi Asfar S.
Published: April 2023

Supplementary Figures
Supplementary Data Table S1 from Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase
Authors: McDonald Gabrielle , Chubukov Victor , Coco John , Truskowski Kevin , Narayanaswamy Rohini , Choe Sung , Steadman Mya , Artin Erin , Padyana Anil K. , Jin Lei , Ronseaux Sebastien , Locuson Charles , Fan Zi-Peng , Erdmann Tabea , Mann Alan , Hayes Sebastian , Fletcher Mark , Nellore Kavitha , Rao Siva Sanjeeva , Subramanya Hosahalli , Reddy K. Satish , Panigrahi Sunil K. , Antony Thomas , Gopinath Sreevalsam , Sui Zhihua , Nagaraja Nelamangala , Dang Lenny , Lenz Georg , Hurov Jonathan , Biller Scott A. , Murtie Josh , Marks Kevin M. , Ulanet Danielle B.
Published: April 2023

Pyrimidine biosynthesis pathway metabolites, p-value and fold change
Tables S1, S2, S3 from Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition
Authors: Shorstova Tatiana , Su Jie , Zhao Tiejun , Dahabieh Michael , Leibovitch Matthew , De Sa Tavares Russo Mariana , Avizonis Daina , Rajkumar Shivshankari , Watson Ian R. , del Rincón Sonia V. , Miller Wilson H. , Foulkes William D. , Witcher Michael
Published: April 2023

Table S1: List of shRNA vectors. Table S2: List of RTqPCR primers.Table S3. List of targeted compounds.
Supplementary Data from Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism
Authors: Overdijk Marije B. , Strumane Kristin , Beurskens Frank J. , Ortiz Buijsse Antonio , Vermot-Desroches Claudine , Vuillermoz Boris S. , Kroes Thessa , de Jong Bart , Hoevenaars Naomi , Hibbert Richard G. , Lingnau Andreas , Forssmann Ulf , Schuurman Janine , Parren Paul W.H.I. , de Jong Rob N. , Breij Esther C.W.
Published: April 2023

Supplemental Tables Supplemental Figures Supplemental Methods
Supplementary Figure Legends and Materials and Methods from Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition
Authors: Shorstova Tatiana , Su Jie , Zhao Tiejun , Dahabieh Michael , Leibovitch Matthew , De Sa Tavares Russo Mariana , Avizonis Daina , Rajkumar Shivshankari , Watson Ian R. , del Rincón Sonia V. , Miller Wilson H. , Foulkes William D. , Witcher Michael
Published: April 2023

Legends for Figures S1, S2, S3 and S4. Supplementary Materials and Methods.
Figure S4 from Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition
Authors: Shorstova Tatiana , Su Jie , Zhao Tiejun , Dahabieh Michael , Leibovitch Matthew , De Sa Tavares Russo Mariana , Avizonis Daina , Rajkumar Shivshankari , Watson Ian R. , del Rincón Sonia V. , Miller Wilson H. , Foulkes William D. , Witcher Michael
Published: April 2023

Cell cycle analysis after BETi/cobimetinib exposure in OVCAR4 cells
Table S4 from Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance
Authors: Huang Zhiqing , Kondoh Eiji , Visco Zachary R. , Baba Tsukasa , Matsumura Noriomi , Dolan Emma , Whitaker Regina S. , Konishi Ikuo , Fujii Shingo , Berchuck Andrew , Murphy Susan K.
Published: April 2023

Differentially expressed genes that exhibit increased expression in the low spheroid-forming capacity cell lines that discriminate between high and low potential to survive serum-free spheroid culture.
Supplementary Table 3 from Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Authors: Udhane Vindhya , Maranto Cristina , Hoang David T. , Gu Lei , Erickson Andrew , Devi Savita , Talati Pooja G. , Banerjee Anjishnu , Iczkowski Kenneth A. , Jacobsohn Kenneth , See William A. , Mirtti Tuomas , Kilari Deepak , Nevalainen Marja T.
Published: April 2023

Antibodies used in the study.
Supplementary Table 2 from Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Authors: Udhane Vindhya , Maranto Cristina , Hoang David T. , Gu Lei , Erickson Andrew , Devi Savita , Talati Pooja G. , Banerjee Anjishnu , Iczkowski Kenneth A. , Jacobsohn Kenneth , See William A. , Mirtti Tuomas , Kilari Deepak , Nevalainen Marja T.
Published: April 2023

Characteristics of patient-derived PCs tested ex vivo in 3D tumor explant cultures for responsiveness to Stat5-inhibitor IST5 in combination with ENZ as a second-line treatment after ENZ.
Supplementary Figure 2 from Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Authors: Udhane Vindhya , Maranto Cristina , Hoang David T. , Gu Lei , Erickson Andrew , Devi Savita , Talati Pooja G. , Banerjee Anjishnu , Iczkowski Kenneth A. , Jacobsohn Kenneth , See William A. , Mirtti Tuomas , Kilari Deepak , Nevalainen Marja T.
Published: April 2023

Levels of nuclear Stat5 in xenograft tumors.
Supplementary Data from Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor
Authors: Balog Aaron , Lin Tai-an , Maley Derrick , Gullo-Brown Johnni , Kandoussi Enzo Hamza , Zeng Jianing , Hunt John T.
Published: April 2023

Supplementary Data includes supplementary materials and methods
Supplementary Data from TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity
Authors: Abusarah Jamilah , Cui Yun , El-Hachem Nehme , El-Kadiry Abed El-Hakim , Hammond-Martel Ian , Wurtele Hugo , Beaudry Annie , Raynal Noël J.-M. , Robert Francis , Pelletier Jerry , Jankovic Maja , Mercier Francois , Kamyabiazar Samaneh , Annabi Borhane , Rafei Moutih
Published: April 2023

Supplementary data.
Table S2 from An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance
Authors: Deng Shanshan , Krutilina Raisa I. , Wang Qinghui , Lin Zongtao , Parke Deanna N. , Playa Hilaire C. , Chen Hao , Miller Duane D. , Seagroves Tiffany N. , Li Wei
Published: April 2023

Table S2 shows the comparison of growth inhibition effects of paclitaxel, VERU-111 and colchicine against treatment-naïve HCI-2-Luc2 and taxane-resistant HCI-10-Luc2 TNBC patient-derived primary cells as measured by the MTS assay (mean {plus minus} SEM, n = 4 biological replicate experiments).
Figure S6 from An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance
Authors: Deng Shanshan , Krutilina Raisa I. , Wang Qinghui , Lin Zongtao , Parke Deanna N. , Playa Hilaire C. , Chen Hao , Miller Duane D. , Seagroves Tiffany N. , Li Wei
Published: April 2023

Figure S6 shows P-gp protein levels of HCI-2-Luc2 and HCI-10-Luc2 patient-derived primary cells and representative endpoint ex vivo bio-imaging data obtained using the taxane-resistant HCI-10-Luc2 patient-derived reporter-labeled xenograft model. (A) P-gp expression in HCI-2 and HCI-10 cells was determined by western blotting. (B) The growth inhibitory effect of colchicine, paclitaxel and VERU-111 was measured in vitro by the IncuCyte S3 live cell imaging system. IC50 values were calculated based on changes in density as measured by phase contrast at study endpoint relative to initial plating density. The bar graphs represent the grand mean {plus minus} SEM of the calculated IC50 values from at least 3 independent experiments. (C-E) Images representative of the mean total photon flux per treatment cohort as determined by ex vivo bio-imaging for the lungs (C), liver (D) and leg bones (E).
Figure S3 from EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells
Authors: Dillard Christen , Kiyohara Meagan , Mah Vei , McDermott Sean P. , Bazzoun Dana , Tsui Jessica , Chan Ann M. , Haddad Ghassan , Pellegrini Matteo , Chang Yu-Ling , Elshimali Yahya , Wu Yanyuan , Vadgama Jaydutt V. , Kim Sara R. , Goodglick Lee , Law Samuel M. , Patel Deven D. , Dhawan Puneet , O'Brien Neil A. , Gordon Lynn K. , Braun Jonathan , Lazar Gary , Wicha Max S. , Wadehra Madhuri
Published: April 2023

Anti-EMP2 mAbs reduce tumor load in two trials using MDA-MB-231 xenograft models.
Supplementary File from The HPV and p63 Status in Penile Cancer Are Linked with the Infiltration and Therapeutic Availability of Neutrophils
Authors: Bernhard Muriel Charlotte , Zwick Anabel , Mohr Tobias , Gasparoni Gilles , Khalmurzaev Oybek , Matveev Vsevolod Borisovich , Loertzer Philine , Pryalukhin Alexey , Hartmann Arndt , Geppert Carol-Immanuel , Loertzer Hagen , Wunderlich Heiko , Naumann Carsten Maik , Kalthoff Holger , Junker Kerstin , Smola Sigrun , Lohse Stefan
Published: April 2023

Supplementary File
Supplementary Figure 6 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
Authors: Flemington Vikki , Davies Emma J. , Robinson David , Sandin Linda C. , Delpuech Oona , Zhang Pei , Hanson Lyndsey , Farrington Paul , Bell Sigourney , Falenta Katarzyna , Gibbons Francis D. , Lindsay Nicola , Smith Aaron , Wilson Joanne , Roberts Karen , Tonge Michael , Hopcroft Philip , Willis Sophie E. , Roudier Martine P. , Rooney Claire , Coker Elizabeth A. , Jaaks Patricia , Garnett Mathew J. , Fawell Stephen E. , Jones Clifford D. , Ward Richard A. , Simpson Iain , Cosulich Sabina C. , Pease J. Elizabeth , Smith Paul D.
Published: April 2023

Supplementary Figure 6
Supplementary Figure 5 from AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib
Authors: Flemington Vikki , Davies Emma J. , Robinson David , Sandin Linda C. , Delpuech Oona , Zhang Pei , Hanson Lyndsey , Farrington Paul , Bell Sigourney , Falenta Katarzyna , Gibbons Francis D. , Lindsay Nicola , Smith Aaron , Wilson Joanne , Roberts Karen , Tonge Michael , Hopcroft Philip , Willis Sophie E. , Roudier Martine P. , Rooney Claire , Coker Elizabeth A. , Jaaks Patricia , Garnett Mathew J. , Fawell Stephen E. , Jones Clifford D. , Ward Richard A. , Simpson Iain , Cosulich Sabina C. , Pease J. Elizabeth , Smith Paul D.
Published: April 2023

Supplementary Figure 5
Table S2 from Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling
Authors: Van De Vyver Arthur J. , Weinzierl Tina , Eigenmann Miro J. , Frances Nicolas , Herter Sylvia , Buser Regula B. , Somandin Jitka , Diggelmann Sarah , Limani Florian , Lehr Thorsten , Bacac Marina , Walz Antje-Christine
Published: April 2023

Estimated parameter values
Figure S5 from Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling
Authors: Van De Vyver Arthur J. , Weinzierl Tina , Eigenmann Miro J. , Frances Nicolas , Herter Sylvia , Buser Regula B. , Somandin Jitka , Diggelmann Sarah , Limani Florian , Lehr Thorsten , Bacac Marina , Walz Antje-Christine
Published: April 2023

Predicted versus observed values plots
Figure S4 from Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling
Authors: Van De Vyver Arthur J. , Weinzierl Tina , Eigenmann Miro J. , Frances Nicolas , Herter Sylvia , Buser Regula B. , Somandin Jitka , Diggelmann Sarah , Limani Florian , Lehr Thorsten , Bacac Marina , Walz Antje-Christine
Published: April 2023

Prediction distribution plots of MKN45 cell line
Figure S9 from Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody
Authors: Al-Khami Amir A. , Youssef Sawsan , Abdiche Yasmina , Nguyen HoangKim , Chou Joyce , Kimberlin Christopher R. , Chin Sherman M. , Kamperschroer Cris , Jessen Bart , Kern Brent , Budimir Natalija , Dillon Christopher P. , Xu Allison , Clark Jerry D. , Chou Jeffrey , Kraynov Eugenia , Rajpal Arvind , Lin John C. , Salek-Ardakani Shahram
Published: April 2023

Supplementary Figure 9 shows the SPR analysis of sasanlimab binding to PD-1 from various species
Figure S1 from Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling
Authors: Van De Vyver Arthur J. , Weinzierl Tina , Eigenmann Miro J. , Frances Nicolas , Herter Sylvia , Buser Regula B. , Somandin Jitka , Diggelmann Sarah , Limani Florian , Lehr Thorsten , Bacac Marina , Walz Antje-Christine
Published: April 2023

Detailed model schematic
Supplementary Figures from WNK1 Enhances Migration and Invasion in Breast Cancer Models
Authors: Jaykumar Ankita B. , Jung Ji-Ung , Parida Pravat Kumar , Dang Tuyen T. , Wichaidit Chonlarat , Kannangara Ashari Rashmi , Earnest Svetlana , Goldsmith Elizabeth J. , Pearson Gray W. , Malladi Srinivas , Cobb Melanie H.
Published: April 2023

Supplementary Figure 1 (Fig S1) shows identification of a WNK1 inhibitor from a chemical screen. Fig S2 shows relationship among AXL, WNK1, OSR1 expression and migration in breast cancer cells. Fig S3 shows effect of WNK inhibitor on cell viability and tumor IHC. Fig S4 shows schematic representation of collaboration among WNK1, OSR1 and AXL.
Supplementary Table S2 from A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer–Induced Osteolytic Bone Resorption
Authors: Pore Subrata K. , Hahm Eun-Ryeong , Kim Su-Hyeong , Singh Krishna B. , Nyiranshuti Lea , Latoche Joseph D. , Anderson Carolyn J. , Adamik Juraj , Galson Deborah L. , Weiss Kurt R. , Watters Rebecca J. , Lee Boeun , Kumta Prashant N. , Singh Shivendra V.
Published: April 2023

Consensus binding sequences for transcription factors
Figure S2 from Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody
Authors: Al-Khami Amir A. , Youssef Sawsan , Abdiche Yasmina , Nguyen HoangKim , Chou Joyce , Kimberlin Christopher R. , Chin Sherman M. , Kamperschroer Cris , Jessen Bart , Kern Brent , Budimir Natalija , Dillon Christopher P. , Xu Allison , Clark Jerry D. , Chou Jeffrey , Kraynov Eugenia , Rajpal Arvind , Lin John C. , Salek-Ardakani Shahram
Published: April 2023

Supplementary Figure 2 shows the confirmation of the primary structure and multi-chain architecture of intact sasanlimab and the identification of the major and minor product isoforms using ESI MS
Supplementary Figure S4 from A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer–Induced Osteolytic Bone Resorption
Authors: Pore Subrata K. , Hahm Eun-Ryeong , Kim Su-Hyeong , Singh Krishna B. , Nyiranshuti Lea , Latoche Joseph D. , Anderson Carolyn J. , Adamik Juraj , Galson Deborah L. , Weiss Kurt R. , Watters Rebecca J. , Lee Boeun , Kumta Prashant N. , Singh Shivendra V.
Published: April 2023

Runt-related transcription factor 2 (RUNX2) occupancy at the promoter of matrix metallopeptidase 9 (MMP9).
Supplementary Figure S1 from A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer–Induced Osteolytic Bone Resorption
Authors: Pore Subrata K. , Hahm Eun-Ryeong , Kim Su-Hyeong , Singh Krishna B. , Nyiranshuti Lea , Latoche Joseph D. , Anderson Carolyn J. , Adamik Juraj , Galson Deborah L. , Weiss Kurt R. , Watters Rebecca J. , Lee Boeun , Kumta Prashant N. , Singh Shivendra V.
Published: April 2023

Summary of gene expression changes following sulforaphane (SFN) treatment in breast cancer cells.
Supplementary Figure 6 from V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer
Authors: Whitton Bradleigh , Okamoto Haruko , Rose-Zerilli Matthew , Packham Graham , Crabb Simon J.
Published: April 2023

Figure S6 shows bafilomycin-A1 impact on AR signalling in LNCaP cells
Supplementary Figure 5 from V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer
Authors: Whitton Bradleigh , Okamoto Haruko , Rose-Zerilli Matthew , Packham Graham , Crabb Simon J.
Published: April 2023

Figure S5 shows mutant AR expression
Supplementary Figure 2 from V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer
Authors: Whitton Bradleigh , Okamoto Haruko , Rose-Zerilli Matthew , Packham Graham , Crabb Simon J.
Published: April 2023

Figure S2 shows GAPDH response to bafilomycin-A1
Supplementary Figure 1 from V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer
Authors: Whitton Bradleigh , Okamoto Haruko , Rose-Zerilli Matthew , Packham Graham , Crabb Simon J.
Published: April 2023

Figure S1 shows concanamycin-A effect on AR signalling
Supplementary Figure 4 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization
Authors: Chandrakesan Parthasarathy , Panneerselvam Janani , May Randal , Weygant Nathaniel , Qu Dongfeng , Berry William R. , Pitts Kamille , Stanger Ben Z. , Rao Chinthalapally V. , Bronze Michael S. , Houchen Courtney W.
Published: April 2023

DCLK1-isoform2 staining is positively and negatively correlated with CD8 T cell staining. Fixed tumor tissues with CD8+ T-cell high ("T-cell high",) CD8+ T-cell mild ("T-cell mild") and CD8+ T-cell low ("T-cell low") from an autochthonous mouse model of pancreatic adenocarcinoma were stained for Dclk1. Bar graph representing the percentage positive staining intensity of DCLK1 between the tissue samples, quantified using ImageJ.
Figure S1 from Preclinical Activity of Ribociclib in Squamous Cell Carcinoma of the Head and Neck
Authors: van Caloen Gabrielle , Schmitz Sandra , El Baroudi Mariama , Caignet Xavier , Pyr dit Ruys Sébastien , Roger Pierre P. , Vertommen Didier , Machiels Jean-Pascal
Published: April 2023

Figure S1 shows the activity of ribociclib in two SCCHN HPV-positive cell lines (SCC47 and SCC90).
Table S2 from Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia
Authors: Zhang Lu , Cai Tianyu , Lin Xiaoyu , Huang Xiaoli , Bui Mai H. , Plotnik Joshua P. , Bellin Richard J. , Faivre Emily J. , Kuruvilla Vinitha M. , Lam Lloyd T. , Lu Xin , Zha Zheng , Feng Weiguo , Hessler Paul , Uziel Tamar , Zhang Qi , Cavazos Antonio , Han Lina , Ferguson Debra C. , Mehta Gaurav , Shanmugavelandy Sriram S. , Magoc Terrance J. , Rowe Jenny , Goodwin Neal C. , Dorritie Kathleen A. , Boyiadzis Michael , Albert Daniel H. , McDaniel Keith F. , Kati Warren M. , Konopleva Marina , Shen Yu
Published: April 2023

Tumor growth inhibition in cell line-based xenograft models and supporting statistics.
Figure S6 from Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia
Authors: Zhang Lu , Cai Tianyu , Lin Xiaoyu , Huang Xiaoli , Bui Mai H. , Plotnik Joshua P. , Bellin Richard J. , Faivre Emily J. , Kuruvilla Vinitha M. , Lam Lloyd T. , Lu Xin , Zha Zheng , Feng Weiguo , Hessler Paul , Uziel Tamar , Zhang Qi , Cavazos Antonio , Han Lina , Ferguson Debra C. , Mehta Gaurav , Shanmugavelandy Sriram S. , Magoc Terrance J. , Rowe Jenny , Goodwin Neal C. , Dorritie Kathleen A. , Boyiadzis Michael , Albert Daniel H. , McDaniel Keith F. , Kati Warren M. , Konopleva Marina , Shen Yu
Published: April 2023

Figure S6.Identification of biomarker of response to ABBV-744/venetoclax therapy.
Supplementary Data from Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics
Authors: Rafidi Hanine , Estevez Alberto , Ferl Gregory Z. , Mandikian Danielle , Stainton Shannon , Sermeño Lauren , Williams Simon P. , Kamath Amrita V. , Koerber James T. , Boswell C. Andrew
Published: April 2023

Supplementary information
Supplementary Table from Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation
Authors: von Achenbach Caroline , Silginer Manuela , Blot Vincent , Weiss William A. , Weller Michael
Published: April 2023

Supplementary table
Supplementary Figure from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Authors: Carter Bing Z. , Mak Po Yee , Tao Wenjing , Zhang Qi , Ruvolo Vivian , Kuruvilla Vinitha M. , Wang Xiangmeng , Mak Duncan H. , Battula Venkata L. , Konopleva Marina , Jabbour Elias J. , Hughes Paul E. , Chen Xiaoyue , Morrow Phuong K. , Andreeff Michael
Published: April 2023

Supplementary Figure from Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic–Resistant AML and AML Stem Cells
Supplementary Data from PCA062, a P-cadherin Targeting Antibody–Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin–expressing Malignancies
Authors: Sheng Qing , D'Alessio Joseph A. , Menezes Daniel L. , Karim Christopher , Tang Yan , Tam Angela , Clark Suzanna , Ying Chi , Connor Anu , Mansfield Keith G. , Rondeau Jean-Michel , Ghoddusi Majid , Geyer Felipe C. , Gu Jane , McLaughlin Margaret E. , Newcombe Rick , Elliot GiNell , Tschantz William R. , Lehmann Sylvie , Fanton Christie P. , Miller Kathy , Huber Thomas , Rendahl Katherine G. , Jeffry Ursula , Pryer Nancy K. , Lees Emma , Kwon Paul , Abraham Judith A. , Damiano Jason S. , Abrams Tinya J.
Published: April 2023

Figures S1, S2, s3, S4, Table S1
Supplementary Data from Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells
Authors: Okajima Daisuke , Yasuda Satoru , Maejima Takanori , Karibe Tsuyoshi , Sakurai Ken , Aida Tetsuo , Toki Tadashi , Yamaguchi Junko , Kitamura Michiko , Kamei Reiko , Fujitani Tomomichi , Honda Tomoyo , Shibutani Tomoko , Muramatsu Sumie , Nakada Takashi , Goto Riki , Takahashi Shu , Yamaguchi Miki , Hamada Hirofumi , Noguchi Yutaka , Murakami Masato , Abe Yuki , Agatsuma Toshinori
Published: April 2023

Supplementary Data from Datopotamab Deruxtecan, a Novel TROP2-directed Antibody–drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells