bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacological Inhibition of Exosome Machinery: An Emerging Prospect in Cancer Therapeutics
Authors: Syeda Saima , Rawat Kavita , Shrivastava Anju
Published: April 2022

Exosomes are nanocarriers that mediate intercellular communication crucial for normal physiological functions. However, exponentially emerging reports have correlated their dysregulated release with various pathologies, including cancer. In cancer, from stromal remodeling to metastasis, where tumor cells bypass the immune surveillance and show drug resistivity, it has been established to be mediated via tumor-derived exosomes. Owing to their role in cancer pathogenicity, exosomebased strategies offer enormous potential in treatment regimens. These strategies include the use of exosomes as a drug carrier or as an immunotherapeutic agent, which requires advanced nanotechnologies for exosome isolation and characterization. In contrast, pharmacological inhibition of exosome machinery surpasses the requisites of nanotechnology and thus emerges as an essential prospect in cancer therapeutics. In this line, researchers are currently trying to dissect the molecular pathways to reveal the involvement of key regulatory proteins that facilitate the release of tumor-derived exosomes. Subsequently, screening of various molecules in targeting these proteins, with eventual abatement of exosome-induced cancer pathogenicity, is being done. However, their clinical translation requires more extensive studies. Here, we comprehensively review the molecular mechanisms regulating exosome release in cancer. Moreover, we provide insight into the key findings that highlight the effect of various drugs as exosome blockers, which will add to the route of drug development in cancer management.
Advancement in Nanoparticle-based Biosensors for Point-of-care In vitro
Diagnostics
Authors: Khizar Sumera , Elaissari Abdelhamid , Al-Dossary Amal Ali , Zine Nadia , Jaffrezic-Renault Nicole , Errachid Abdelhamid
Published: April 2022

Recently, there has been great progress in the field of extremely sensitive and precise de-tection of bioanalytes. The importance of the utilization of nanoparticles in biosensors has been rec-ognized due to their unique properties. Specifically, nanoparticles of gold, silver, and magnetic plus graphene, quantum dots, and nanotubes of carbon are being keenly considered for utilization within biosensors to detect nucleic acids, glucose, or pathogens (bacteria as well as a virus). Taking ad-vantage of nanoparticles, faster and sensitive biosensors can be developed. Here, we review the na-noparticles' contribution to the biosensors field and their potential applications.
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds
Authors: Jothimani Ganesan , Ganesan Harsha , Pathak Surajit , Banerjee Antara
Published: April 2022

Background:

Metastasis is the world's leading cause of colon cancer morbidity. Due to its heterogeneity, it has been challenging to understand primary to metastatic colon cancer progres-sion and find a molecular target for colon cancer treatment.

Objective:

The current investigation aimed to characterize the immune and genotypic profiles of primary and metastatic colon cancer cell lines and identify a molecular target for colon cancer treatment.

Methods:

Colony-forming potential, migration and invasion potential, cytokine profiling, miRNA, and mRNA expression were examined. Molecular docking for the Wnt signaling proteins with vari-ous plant compounds was performed.

Results:

Colony formation, migration, and invasion potential were significantly higher in metastatic cells. The primary and metastatic cells' local immune and genetic status revealed TGF β-1, IL-8, MIP-1b, I-TAC, GM-CSF, and MCP-1 were highly expressed in all cancer cells. RANTES, IL-4, IL-6, IFNγ, and G-CSF were less expressed in cancer cell lines. mRNA expression analysis displayed significant overexpression of proliferation, cell cycle, and oncogenes, whereas apoptosis cascade and tumor suppressor genes were significantly down-regulated in metastatic cells more evidently. Most importantly, the results of molecular docking with dysregulated Wnt signaling proteins shows that peptide AGAP and coronaridine had maximum hydrogen bonds to β-catenin and GSK3β with a better binding affinity.

Conclusion:

This study emphasized genotypic differences between the primary and metastatic co-lon cancer cells, delineating the intricate mechanisms to understand the primary to metastatic ad-vancement. The molecular docking aided in understanding the future molecular targets for bioac-tive-based colon cancer therapeutic interventions.
Ugi Adducts: Design and Synthesis of Natural-based α-glucosidase
Inhibitors
Authors: Iraji Aida , Saeedi Mina , Rafiee-Sereshky Tina , Mojtabavi Somayeh , Faramarzi Mohammad Ali , Akbarzadeh Tahmineh
Published: April 2022

Background:

α-Glucosidase inhibitors have been found as the main tool for the treatment of
type 2 diabetes. In this respect, the synthesis of a new series of amino-oxoethylcinnamamide derivatives
containing α,β-unsaturated carbonyl-based moiety, was developed to be evaluated for their anti-α-
glucosidase activity.

Methods:

The title compounds were synthesized via the Ugi reaction of cinnamic acid, isocyanides,
aromatic aldehydes, and amine derivatives at ambient temperature. All newly synthesized derivatives
were screened for their in vitro α-glucosidase inhibitory activity.

Results:

Among synthesized compounds, derivative 5b displayed promising anti-α-glucosidase activity
(IC50 = 115.6 μM), approximately 6-fold more potent than the standard drug (acarbose, IC50 = 750.0
μM). Moreover, kinetic characterization of enzyme inhibition was performed to understand the mechanism
of inhibition. To determine the mode of binding interactions of prepared compounds with the enzyme,
molecular docking studies were also conducted.

Conclusions:

Ugi products merit to be investigated in anti-diabetic drug discovery developments.
This paper is dedicated to our unique teacher of Chemistry and Medicinal Chemistry, Professor Abbas Shafiee
(1937-2016).
Flavonoid Content in Extract Fractions of Morus alba (mulberry) Inducing
Apoptosis in A549 Human Epithelial Lung Carcinoma Cells
Authors: Prakash Om , Singh Ruchi , Kumar Rajesh , Singh Namrata , Verma Neelam , Gupta Amresh , Ved Akash
Published: April 2022

Background:

Cancer is one of the leading chronic diseases with a high mortality rate
worldwide. Current statistical studies on cancer from the World Health Organization (WHO) in
2020 estimated that cancer is the first or second leading cause of death.

Objective:

The current study investigated the phytochemical, antioxidant, and anticancer effect of MeOH
extract of Morus alba leaves, superoxide scavenging assay, metal chelating, DPPH, and MTT assay employed.

Methods:

MTT assay was performed on A549 cells and chick embryo fibroblasts were used as the control.
DNA fragmentation and real-time assays were performed to check apoptosis and gene expression levels.

Results:

Findings suggest that the MeOH extract of Morus alba exhibited a significant antioxidant activity
compared to standard antioxidants. MeOH extract and chloroform fraction exhibited strong selectivity of
toxicity toward A549 human lung carcinoma cells without affecting normal cells. The chloroform fraction
was found to be most active in the MTT assay against A549 cells, while it was less toxic to normal cells.
Cells exposed to IC50 concentration for the cytotoxicity study of the chloroform fraction exhibited a breakdown
of DNA. Increased expression of p53, Bax, caspase-3 and reduced expression of Bcl-2 gene gave
evidence that the chloroform fraction might induce apoptosis.

Conclutions:

It was concluded that the MeOH extract and its fractions of Morus alba leaves possessed immense
potential for tumor treatment. Therefore, it would be necessary to carry out further studies to isolate
and identify the active principles responsible for these activities.
Phytopharmacological Review of a Food Supplement Zingiber officinale
Roscoe (Zingiberaceae)
Authors: Subraya Chandrashekar Kodangala , Pai Vasudev , Sri Baby Sai , Nanjundaiah Aswatha Ram Holavana Halli
Published: April 2022

Zingiber officinale, a medicinal herb commonly used in Ayurveda belongs to family
Zingiberaceae and is reported to have various therapeutic properties. Roots as well as rhizomes
of this plant are commonly used in the treatment of digestive disorder. It has also been used as
expectorant, spasmolytic, anti-tussive, anti-allergic, antihistaminic activity and inhibits coughing.
The roots and rhizomes are rich sources of essential oil, which may be one of the reasons for
medicinal properties. Required data on this plant were obtained from electronic sources (google
scholar, PubMed, Scopus, Web of Science), several classical textbooks on Ayurveda, and ethnopharmacology.
This review article covers all the relevant information on its pharmacological
and phytochemical aspects. In this study, we have critically reviewed recent advancements of
Zingiber officinale in an attempt to authenticate its use as a multipurpose therapeutic ingredient.
Potential Benefits of Pila ampullacea, Tempeh, Moringa oleifera Leaves as
Nutritional Support for Hemodialysis
Authors: Widiany Fery Lusviana , Sja’bani Mohammad , Susetyowati  , Soesatyo Marsetyawan , Lestari Lily Arsanti , Pratiwi Woro Rukmi , Wahyuningsih Mae Sri Hartati , Huriyati Emy
Published: April 2022

Background:

Hemodialysis patients can experience problems, including proteinenergy
malnutrition, infection, disorders of the immune system, and inflammation. One etiology
of malnutrition in hemodialysis is inadequate energy and protein intake, making patients need
nutritional support, which can be fulfilled by local Indonesian foodstuffs.

Objective:

This paper aimed to review the potential health benefits of snails (Pila ampullacea),
tempeh, and Moringa oleifera leaves as nutritional support for hemodialysis patients.

Methods:

In this review, the methodology used was based on comprehensive data searched from
PubMed for literature review and technology benchmarking in making nutritional support for
hemodialysis patients. An in-depth discussion, including the advantages and drawbacks of each
foodstuff, is presented and outlined. Furthermore, key solutions are proposed and presented to
overcome hemodialysis issues.

Results:

The mixture of snail, tempeh, and moringa leaves as nutritional support for hemodialysis
patients shows a good combination of natural ingredients from animals and plants. The nutritional
content of the three mixed ingredients is found to meet the dietary requirements of hemodialysis,
which are high protein, calcium and antioxidants, low phosphorus, and a phosphorus-toprotein
ratio of <16.

Conclusion:

The combination of snails, tempeh, and moringa leaves provides several potential
health benefits in overcoming nutritional problems, decreased immune status, and inflammation
of hemodialysis patients.
Dendritic Cells - Winning the Fight against HIV
Authors: Sheykhhasan Mohsen , Poondla Naresh , Ahmadyousefi Yaghoub , Akbari Mohammad , Seyedebrahimi Reihaneh , Farsani Mohsen Eslami , Kalhor Naser
Published: April 2022

HIV is a virus that targets and hijacks the immune cells of the host. It multiplies by attacking
the helper T-lymphocytes. HIV has remained one of the most difficult and dangerous infections in the
world due to the inability to find a successful treatment and a lack of access to medical care. When the
virus reaches the body, dendritic cells are the first cells it encounters. DCs have been identified as one of
the most effective mediators of immune responses, implying a promising strategy against viral infection.
The current state of knowledge about the function of dendritic cells and their subsets is critical for using
their full potential as a candidate for the development of an HIV vaccine. Despite extensive efforts, a
reliable vaccine with the fewest side effects has yet to be found, and further research is needed to find a
dependable and efficient vaccine. The extent to which dendritic cell-based therapy is used to treat HIV
was investigated in this study. As the virus attacks the host immune system, the dendritic cells can trigger
an immune response against HIV-1 infection.
The Effect of Aspirin on the Prevention of Pro-thrombotic States in Hospitalized
COVID-19 Patients: Systematic Review
Authors: Zangiabadian Moein , Nasiri Mohammad Javad , Abdi Masoumeh , Lamardi Zahra Hoseini , Shirjan Fatemeh , Mohammadi Leila , Abadi Sahel Shafiee Dolat , Massoudi Nilofar
Published: April 2022

Introduction:

Thromboembolic events are one of the important complications in
COVID-19 patients, especially in severe cases. Aspirin affects platelet function by irreversibly
inhibiting cyclooxygenase activity, reducing the risk of thrombosis. The current systematic review
aimed to evaluate aspirin's effectiveness in preventing pro-thrombotic states in COVID-19 hospitalized
patients.

Methods:

The systematic search was done in PubMed/Medline, EMBASE, and Medrxiv until
September 27, 2021. The following keywords were used: “COVID-19”, “SARS-CoV-2”, “2019
Novel Coronavirus”, “Aspirin,” and “Acetylsalicylic Acid.”

Results:

Twelve studies were included. In COVID-19 patients, aspirin can reduce CRP, IL-6 levels,
and platelet aggregation by inhibiting thromboxane A2. It can also improve antiviral immunity
by hindering the biosynthesis of prostaglandins and lipoxin. Eight out of twelve articles indicated
that aspirin provided a beneficial effect on COVID-19. Most studies consider lowered mechanical
ventilation needs, ICU admission, illness severity, overt thrombosis, and clinical outcomes in
COVID-19 patients receiving aspirin.

Conclusions:

Aspirin as an antiplatelet and anti-inflammatory agent may reduce the mortality rates
in hospitalized patients with severe COVID-19. Further observational studies are necessary to
determine the effect of aspirin on the prevention of pro-thrombotic states in hospitalized COVID-
19 patients.
The study was registered in the Systematic Review Registration: PROSPERO (pending registration
ID: 300515).
A New Wave of COVID-19 in 2021 with Unique Genetic Characters - Present Global Scenario and Beholding Onwards
Authors: Mukherjee Sukhes , Ray Suman Kumar
Published: April 2022

After the first report of a coronavirus-associated pneumonia outbreak in December 2019, the
virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) that causes the infection/disease
(COVID-19) has developed into a pandemic, with >100 million people infected in over 210 countries
along with two million people deceased from COVID-19 till today. Coronaviruses are positivestranded
RNA viruses having restricted RNA polymerase proofreading ability thus it is very genetically
susceptible to mutation. The evolution of SARS-CoV-2 from a single-point zoonotic introduction in
Wuhan in November or December 2019 was widely expected, and viral sequence surveillance was
developed as a result. When the first sequence of SARS-CoV-2 was released, a race to develop vaccines
started, and several vaccines are now used worldwide. Independent SARS-CoV-2 lineages have
recently been identified in the UK (B.1.1.7), Brazil (P.1), South Africa (B.1.351), and India (B.1.617).
The recent appearance of several SARS-CoV-2 variant strains has shattered faith in the modern generation
of vaccines' ability to provide enduring defense against infection. The risk of escaping natural
and induced immunity has encouraged an urgency to comprehend the implications of these improvements,
as well as a drive to develop new approaches to combat SARS-CoV-2 variants.
Importance of Pharmacophore in Designing Anticonvulsant Agents
Authors: Kale Amol , Kakde Rajendra , Pawar Smita , Jagtap Vishal , Dorugade Rahul
Published: April 2022

Drug design is one of the critical aspects of the drug development process. The present
review focused on different heterocyclic molecules having anticonvulsant activity with structural
diversity and common pharmacophoric features. For the first time (1995), Dimmock and his team
introduced specific arrangements of three important pharmacophores for anticonvulsant activity. These
pharmacophores include two hydrophobic binding sites and one hydrogen binding site. After a few
years (2012), Pandeya modified Dimmock’s concept by adding one more pharmacophoric feature as
an electron donor in the previously suggested pharmacophoric arrangement of the anticonvulsant. As a
result, numerous scientists designed anticonvulsant drugs based on Dimmock’s and Pandeya’s concept.
In addition, marketed anticonvulsant preparation containing Riluzole, Phenobarbital, Progabide,
Ralitoline, etc., also holds the suggested pharmacophores by Dimmock and Pandeya’s pharmacophoric
concept. This review mainly focuses on the compilation of reported scientific literature in the last decade
on the pharmacophoric features of different heterocyclic anticonvulsants, which will help develop
new anticonvulsants.
Current Drug Targets in Alzheimer’s Associated Memory Impairment: A
Comprehensive Review
Authors: K.S Chandrashekar , Mathew Anna , Balaji E Vignesh , Pai Sreedhara Ranganath K. , Kishore Anoop , Pai Vasudev , Pemmireddy Ramadevi
Published: April 2022

Alzheimer’s disease (AD) is the most prevalent form of dementia among geriatrics. It is a
progressive, degenerative neurologic disorder that causes memory and cognition loss. The accumulation
of amyloid fibrils and neurofibrillary tangles in the brain of AD patients is a distinguishing feature
of the disease. Therefore, most of the current therapeutic goals are targeting inhibition of beta-amyloid
synthesis and aggregation as well as tau phosphorylation and aggregation. There is also a loss of the
cholinergic neurons in the basal forebrain, and first-generation therapeutic agents were primarily focused
on compensating for this loss of neurons. However, cholinesterase inhibitors can only alleviate
cognitive symptoms of AD and cannot reduce the progression of the disease. Understanding the molecular
and cellular changes associated with AD pathology has advanced significantly in recent decades.
The etiology of AD is complex, with a substantial portion of sporadic AD emerging from unknown
reasons and a lesser proportion of early-onset familial AD (FAD) caused by a mutation in several
genes, such as the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2)
genes. Hence, efforts are being made to discover novel strategies for these targets for AD therapy. A
new generation of AChE and BChE inhibitors is currently being explored and evaluated in human
clinical trials for AD symptomatic treatment. Other approaches for slowing the progression of AD include
serotonergic modulation, H3 receptor antagonism, phosphodiesterase, COX-2, and MAO-B inhibition.
The present review provides an insight into the possible therapeutic strategies and their molecular
mechanisms, enlightening the perception of classical and future treatment approaches.
Motion Planning for Autonomous Vehicles Based on Dynamic Bio-inspired Neural Network Model
Authors: Song Jia Yan , Su Shengchao , Yang Chen
Published: April 2022

Background:

Nowadays, with the increase of the number of cars, traffic accidents occur
frequently, improving the active safety of cars, and traffic safety has become an inevitable requirement
of the development of intelligent transportation.

Objective:

Motion planning for autonomous driving is a challenging problem due to the uncertainty
of the unknown complex environment. Conventional methods may fail in some cases on account of
poor real-time performance and instability. The objective is to propose a motion planning method
to plan a reasonable path autonomously for an autonomous vehicle in unknown environments and
ensure obstacle avoidance.

Methods:

The solution is to use the improved Glasius Bio-inspired Neural Network (GBNN) to
plan a feasible route for the autonomous vehicle, which adaptively changes the direction of movement
according to the changes of neuron values. Neuron connection weight in the neural network is
reasonably improved to increase the update rate of activity value, so that this model can more adapt
to the changes of dynamic environment. Meanwhile, the planned trajectory is fitted to meet vehicle
kinematics model.

Results:

Unstructured and structured roads are tested in static and dynamic environments, respectively.
During the test, static obstacles and surrounding vehicles’ intentions are all generated randomly.
In this way, the generated route can be optimal and adapt to the stochastic as well.

Conclusion:

Simulation results in unstructed road and structed road show the effectiveness of the
proposed algorithm in autonomous motion planning. In addition, the performance of path length,
smoothness and turning angle has been improved.
Agar Microdilution Procedure: A Promising Technique for Antimicrobial
Susceptibility Test of Colloidally Unstable Nanostructures
Authors: Ghanbariasad Ali , Ebrahiminezhad Alireza , Moradi Nahid , Taghizadeh Seyedeh-Masoumeh , Berenjian Aydin
Published: April 2022

Background:

Broth microdilution is the only available microscale endpoint technique used to
evaluate the antimicrobial potency of nanostructures. In the case of unstable nanostructures or at high
concentrations of nanostructures, this technique is not applicable due to aggregation and sedimentation
issues. Most nanostructures can absorb visible light, and this optical feature can interfere with the OD600
measurement that is commonly employed for the evaluation of microbial cells growth. The demand for
high-tech plate readers is another limitation of the broth microdilution procedure. Agar microdilution can
be a promising novel procedure to overcome all these technical difficulties.

Objective:

In the current experiment, the agar microdilution procedure was developed and introduced to
be employed for the evaluation of antimicrobial potency of colloidally unstable nanostructures even at
extremely high concentrations.

Methods:

Thymus daenensis herbal nanoparticles (HrbNPs) were fabricated through a top-down approach
and were tested against methicillin-resistant Staphylococcus aureus (MRSA). Also, the particles were
fortified with povidone-iodine and peracetic acid as potent antimicrobial compounds to achieve the enhanced
antimicrobial activity.

Results:

Viscose molten agar media prevented the particles from sedimentation during 96-well plate
preparation. By agar solidification, the nanoparticles were immobilized in the media, and no aggregation
or sedimentation could occur. After incubation, the bacterial growth was recognizable in the well as a thin
creamy layer. The MIC of HrbNPs against MRSA was found to be 20 mg/ml. Fortification with povidone-
iodine had no impact on the antimicrobial potency of HrbNPs. However, fortification of HrbNPs
with peracetic acid resulted in a four-fold increase in the antimicrobial potency of nanoparticles, and MIC
was reduced to 5 mg/mL.

Conclusions:

Results indicated that agar microdilution can be a promising procedure for the antimicrobial
susceptibility test of nanostructures at extremely high concentrations. Also, colloidally unstable
nanostructures can be tested via this procedure without any concern for possible aggregation and sedimentation.
On the other hand, it was found that fortification with antimicrobial compounds can be an
effective approach to increasing the antimicrobial potency of HrbNPs against superbugs.
Performance Analysis of Low GWP Refrigerants R1234yf and R448A in a
Small High and Low-temperature Test Equipment
Authors: Liqiang Zhou , Zhang Hua , Zilong Wang , Wenjing Gao
Published: April 2022

Aim:

The article presents an analysis of the feasibility of R1234yf and R448A, two new low
GWP refrigerants, as alternatives to R404A in the refrigeration system of small high and lowtemperature
test equipment.

Methods:

The physical properties of R448A and R404A are similar. Compared with R404A, the GWP
of R1234yf and R448A reduced by 99.9% and 67.7%, respectively. The analysis is based on an experimental
comparison of R404A with R448A and R1234yf, comparing the compressor discharge temperature,
COP, cooling capacity, and the cooling rate of three refrigeration systems at different ambient
temperatures.

Results:

The experimental results show that the cooling capacity of R448A is better than R404A at a
higher condensing temperature.

Conclusion:

When the charging volume is 230g, and the ambient temperature is 25℃, the COP of the
R448A system is increased by about 24.63% compared with the R404A system.
A Review of Traditional Uses, Phytochemistry, and Pharmacology of
Salvia chloroleuca Rech. f. & Aellen
Authors: Salimikia Iraj , Mirzania Foroogh
Published: April 2022

Background:

Salvia chloroleuca Rech. f. & Allen is an endemic or native perennial medicinal
plant growing wildly in central, north, and northeast Iran. Objective: The aim of this research
was to provide an overview of the chemical profile of Salvia chloroleuca, the principal chemical
compounds, and their various biological activities and uses in traditional pharmacopoeia.

Method:

The literature search was done via specialized search databases (SciFinder, Scopus, Pub-
Med, Web of Science, and Google Scholar).

Results:

From the past to the present, people have consumed Salvia chloroleuca for carminative, antibacterial,
antitumoral, antiviral, antifungal, antiparasitic, antirheumatic, tonic, hepatoprotective,
nephroprotective, immunoprotective, anticancer and neuroprotective properties. The principal ingredients
of Salvia chloroleuca are salvigenin, luteolin, cirsiliol, daucosterol, and β-sitosterol, and
these substances may be responsible for the herb's remedial properties. The bioactive components
extracted from Salvia chloroleuca have promising prospects and make it possible to propose diverse
solutions due to their excellent dissimilarity and bioactivity for such various usages.

Conclutions:

This study is a valuable resource for further research and improvement of the varied
features of Salvia chloroleuca secondary metabolites. This study is a valuable source of information
regarding an important native medicinal plant. It can be extended for new investigations in the fields
of phytochemistry and pharmacology, with the purpose of searching for novel natural bioactive
structures with therapeutic properties.
An Overview of the Quality of Life in Patients With Schizophrenia
Authors: Völker Jes S. , Micluția Ioana V.
Published: April 2022

Schizophrenia is one of the most common and devastating mental disorders. While
control of positive clinical symptoms can be achieved relatively robustly, other clinical signs
such as negative symptoms or cognitive problems can be more difficult to treat.
This narrative review was undertaken to give an overview of how these and other factors impact
a patient’s quality of life. Ample evidence shows that clinical symptoms of any kind have
a negative impact on quality of life. Numerous factors, however, play an important role in the
overall well-being of the patients in such a way that a mere focus on clinical symptom control
is not enough to improve quality of life. These factors include psychological traits of the patient,
socioeconomic factors such as education and employment status, gender ethnicity, medication
side effects, stigma, and psychiatric comorbidities. Maximizing quality of life as the
main treatment focus should, therefore, include a comprehensive approach that keeps all these
factors and their complicated interplay in mind in order to deliver the best possible treatment.
Identification of Surface Water Treatment Plan (WTP) Effluent and Distribution Water Quality in Wonogiri Regency, Central Java
Authors: Oktaviani Whindy , Sarwono Ariyanti , Suryawan I Wayan
Published: April 2022

This study analyzed the water treatment system into drinking water, and the quality of raw water and distribution results at Perumda Air Minum Giri Tirta Sari, Wonogiri Regency. The water treatment plant's (WTP) for surface water consists of intake, pre-sedimentation, coagulation, flocculation, sedimentation, filtration, reservoir storage, and distribution. The sludge resulting from the deposition process is still not managed. Further planning is needed to control environmental pollution that may occur due to dumping sludge into streams. The quality of river raw water that has not met the quality standard is total coliform and color. Measurement of water on the customer's tap shows that all the quality standards of drinking water have met the criteria to be safe for use by residents
Analysis of Flood Peak Discharge Based on Watershed Shape Factors
Authors: Muhadi Muhadi , Limantara Lily , Prayogo Tri
Published: April 2022

Regression analysis can develop unit hydrograph modeling by approaching the peak discharge (Qp) and time to peak (Tp) parameters. The main aim of this study is to design a model of peak discharge based on watershed shape factors. The watersheds used in this study are Bontojai Watershed, Jonggoa Watershed, Kampili Watershed, Maccini Sombala Watershed, and Jenelata Watershed, which have slopes criteria below 10% and have complete recorded data of Automatic Water Level Recorder (AWLR) and Automatic Rainfall Recorder (ARR). The validation results of corrected peak discharge data produce Root Mean Squared Error (RMSE). Then, the peak discharge model was conducted by regression analysis and validated with observed unit hydrographs. The results of this study indicate that the coefficient of determination R2 is 0.963. It means that the independent variable (x), namely the area of the watershed, the length of the main river, and the shape factor of the watershed, influences the peak discharge (Qp) of 96.3%
Impact on The Existence of New Toll Road Section Due to Mode Choice Between Transportation Mode Using Modal Split Methods (Case Study: Tulungagung-Surabaya)
Authors: Bahariansyah Muhammad , Herijanto Wahyu , Widyastuti Hera
Published: April 2022

The Java-trans highway is almost connected from west to the east of Java Island and now, there is a new section that will be built, those are Kertosono-Kediri section and Kediri-Tulungagung section. The Impact from these construction in the future will shorten the travel time. Tulungagung-Surabaya buses which use the highway only take 3-3,5 hours of travel time with route combinations between national and highway roads. This research aims to find the model of mode choice proportion between bus, non-toll bus, cars, and train due to Tulungagung-Surabaya’s highways in 2023. The travel attributes used in this research are travel time and travel cost between bus, non-toll bus, cars, and train. Then, the model could predict the mode choice proportion in the future, after the construction finished. The method for modelling is modal split which uses power function (α) and deterrence function (β). Mode choice model that is used is a modal split with power function (α) with NMAE values 0,5284 which is close to 0. The interpretation of NMAE value is the smaller the value the better the model, because the model would represent the existing condition in which the model could predict future condition
Analysis of Changes in Land Use Patterns for Erosion and Sediment Prediction
Authors: Arifin Syamsul , Suhartanto Ery , Andawayanti Ussy
Published: April 2022

The Amprong watershed has an area of ± 252.94 km². The increasing population causes the demand for land to increase. GIS analyzes changes with the factors of change that occur. The purpose of the study was to determine the pattern of land-use change in the Amprong watershed on erosion and sedimentation. Idrisi Selva for use change analysis and SWAT for erosion and sediment. From the results of land cover modeling, it can be seen that the trend of forest land cover change from 2008, 2013, and 2018 continued to decline with an average of 11.69% of land cover in 2008. In contrast to settlements, it always increased by an average of 9.29%. Meanwhile, land cover changes in 2018 and 2028 decreased by 21.40%, plantations decreased by 4.33%, open land decreased by 42.11%, settlements increased by 46.47%, rice fields increased by 0.60%, and shrubs increased by 4.63%. The Kappa Index of Agreement validation shows a K standard value of 0.85 which means that the modeling is scientifically accepted. The results of hydrological modeling in 2018 were 1,021,237.49 tons/ha/year, erosion was 752,973.95 tons/ha/year and in 2028 it was 1,886,689.64 tons/ha/year, erosion was 1,069,631.09 tons/year
Kepemimpinan Transformasional dalam Pelayanan e-Procurement (Studi di Unit Pengelola Pengadaan Barang dan Jasa Universitas Timor)
Authors: Payon Filogus Naboyut
Published: April 2022

Leaders roles in building working environment are vital. Therefore, transformational leadership required motivation and performances. This research aimed to investigate role of transformational leadership in e-Procurement at the Goods and Services Procurement Management Unit at the University of Timor. How transformational leadership and what factors obstruct and support in e-Procurement implementations. This research uses descriptive-qualitative approach to obtain comprehensive overview. The result shows that principal implementations in goods/ services and transformational leadership roles in e-Procurement has been implemented. Lack of human resources, low management competence in procurement and unclear career developments impact administrators on how serious they are. Nevertheless, Head of UPPBJ at University of Timor has high commitment becomes great power to reach the vision, mission and goals. Also, the existence of procurement agent can direct, guide and offer solutions to any obstacles faced by UPPBJ at University of Timor.
Sinkronisasi Perencanaan Tata Ruang Daerah dengan Pembangunan Jalan Tol Berbasis Sustainable Development
Authors: Nurristi Dinartika Arneda , Sarwono Sarwono , Nuh Mohammad
Published: April 2022

This study describes the synchronization of spatial planning with the construction of toll road-based sustainable development in the Area of Interchange Tol Madiun. Aimed to explore the information from some source: BAPPEDA Kabupaten Madiun, Dinas PUPR Kabupaten Madiun, Office of the Bagi Village, and Communities around the Interchange Tol Madiun. The results showed that; first, the synchronization of spatial planning with the construction of the Madiun toll road not fully following the RT/RW (community association) plan and unable to be categorized as ideal planning. The application of the participation has been running well, but there is still a discrepancy on the principle of continuity and holistically. Second, the implementation of Sustainable Development in the construction of the toll road is not running balance between economic development, social and environmental. Supporting factor form is the strong legal basis and the high level of community participation. Inhibiting factors in the form of rationalization of the budget because of the pandemic Covid19 and the lack of personals resource that is pure has graduated in spatial studies.
Implementasi Pendaftaran Tanah Sistematis Lengkap Berbasis Partisipasi Masyarakat di Desa Dukuh Kecamatan Ngadiluwih Kabupaten Kediri
Authors: Firdausi Rohmatina
Published: April 2022

Regulation of the Minister of Agrarian and Spatial Planning / Head of National Land Agency Number 6 of 2018 on 2018 on Complete Systematic Land Registration has been improved by adding its implementation based on society participation. This is to achieve the target in 2025 that all land must be registered. Kediri Regency in 2019 has 1.386 km² of land from 1.523.92 km² have not been certified. The head of the Kediri Regency Land Office formed 4 PTSL working area unit team but can not to handle the number of targets that had to be solved. Technical instructions of PTSL+PM is a reference to implement PTSL +PM in Dukuh Village so that the society can be actively helped Puldatan work quickly and carefully. The study aims to determine the implementation model of a complete systematic land registration policy based on society participatition in the Dukuh Village. The research method that will be used is a descriptive qualitative. Research has been taken and the resulths show that the implementation of the PTSL+PM policy in Dukuh Village has done well and achieve the registration target of 85% of the total quota of 2500 fields. This is seen from the content of the policy that requires the interests of the President in ensuring legal law. Adequate resource in terms od human resources, budget, facilities make implementation has done optimally in Dukuh Village.
Smart Kampung, Mereduksi Birokratisasi Pelayanan Publik (Studi pada Desa Wringinrejo, Kecamatan Gambiran, Kabupaten Banyuwangi)
Authors: Aziz Nana Abdul , Putri Novi Permata
Published: April 2022

Smart Kampung program is a program that is applied throughout the village within the scope of the Banyuwangi Regency Government. The program utilizes Information Technology (IT) to make it easier for people to get public services. This research aims to describe and analyze the implementation of services, especially in terms of population administration through the Smart Kampung program in Wringinrejo Village. Qualitative descriptive methods became the most rational choice in research, and data analysis was conducted with the interactive models of Miles, Huberman and Saldana. Data collection is done by observation, interview and documentation.The simple conclusion of this study shows that the implementation of public services through the Smart Kampung program is still not optimal given the lack of education to the community about the ease of the public service process through Smart Kampung, and the lack of details of budget utilization.
Model Pembinaan Pegawai untuk Meningkatkan Kinerja di UB Guest House
Authors: Saputro Lukman Khamdani , Gani Abdul Juli Andi , Novita Asti Amelia
Published: April 2022

The purpose of this research is to find out how to develop employees at UB Guest House, what obstacles are encountered, and how to overcome these obstacles. These employee development activities include: education and training, career education, and discipline education. This study uses a qualitative method using triangulation techniques. The results show that: the management of UB Guest House is expected to set a clear budget in an effort to support the financing of career development policies, where the development must be carried out for employees who have potential in terms of education and work experience; as well as providing motivation to employees and increasing organizational commitment. This can be achieved by carrying out various coaching such as: training, promotion, and transfer.
Community Mobilization Led by Lay Actor, a Directed Participation in Tax Culture
Authors: Utomo Rachmad
Published: April 2022

Community leaders indeed become strategic actors for the government. In Pondok Aren, a meatball seller has led the UMKM Sahabat Pajak (USP) or micro, small, and medium enterprises (SME) community tax-friendly, they were successfully directed to mobilize a social movement "We're great at paying taxes" (Bayar Pajak Untung). This study aims to describe how Kantor Pelayanan Pajak (tax office) Pondok Aren seeks lay actors and builds their capacity to become community movers. With the ethnographic research method, the findings show that the government needs to be diligent in looking for them, getting to explore them from the original place every day they are working because persuading citizens with social capital is not enough. The government should not be fascinated by educational and professional backgrounds because it does not guarantee the noble attitude of citizens who voluntarily participate in building a functioning society towards social welfare.
Strategy to Improve Accountability and Performance Management in Pamekasan Regency Government
Authors: Winoto Suhartono
Published: April 2022

The level of accountability for the performance of the Pamekasan Regency Government in recent years has experienced a significant increase, so a strategy is needed so that the value of accountability continues to increase. The purpose of this study is to provide an overview of strategies for improving accountability and performance management in the government in Pamekasan Regency. The results of the study indicate that strategies for increasing accountability and performance management in the Pangandaran Regency Government include the Regional Apparatus Organization conducting a satisfaction survey on the community in each of its services periodically, the need to strengthen SOP (Standard Operating Procedures) in public services, increasing standard adjustments and review programs with community involvement (citizen charter), increasing the intensity level of coordination between regional apparatuses in order to improve public service innovation, providing and managing public complaints facilities, encouraging service innovation in each regional apparatus, and conducting periodic socialization of service evaluation policies.
Perilaku Pemilih dalam Menentukan Keputusan Politik di Indonesia pada Awal Era Reformasi
Authors: Maskur Ali
Published: April 2022

This study aims to analyze voters' behavior in the presidential election in Indonesia. To achieve this goal, researchers limited the period only to the reform period. This is because at this time the political freedom of the people in choosing the president was very protected compared to the previous era. Voter behavior is identified from the political decisions of voters in determining the president and vice president. There are 3 main approaches used to analyze voter behavior, namely sociological, psychological, and rational choices. This research was conducted by using qualitative descriptive method with data collection techniques through observation and documentation. Because researchers are also voters, researchers are the main instrument of this research. The results showed that sociological and psychological factors greatly influenced voter behavior in determining political choices. Emotional voters towards leaders and parties form their attachment to candidates and political parties who ultimately determine their political decisions. In addition, similarities in ethnicity, religion, and regionalism also provide emotional voters in determining their political decisions.
Empowerment of Marginalized Group through Rural Women's School
Authors: Noventi Ike Arni
Published: April 2022

Women as marginal groups have a large number in Indonesia. Women, especially in the rural area, generally have very limited knowledge and skills and they become more marginalized. Actualy they can become potential in national development if empowered. This research tries to describe the process of rural women empowerment in rural women’s school. Using descriptive research methods and qualitative approaches, this research focused on women's empowerment activities, learning systems, involved stakeholders and barriers faced by rural women's schools. The results of the study showed that empowerment activities were carried out by giving motivation, knowledge and skills. Learning system conducted through method of giving material, practice, and outclass. Stakeholders involved in running the schools are government, private sector, community and university. The obstacles in the implementation of this school are the fluctuating number of participants, limited funding, communication, and adjustment material training due to the absence of presenters.
Evaluasi Pelaksanaan UNBK (Ujian Nasional Berbasis Komputer) (Studi Pada SMAN 5, SMKN 6 & SMK Wisnuwardhana Kota Malang)
Authors: Ernawan Rizky Deandra
Published: April 2022

The UNBK (Computer-Based National Examination) policy is one of the efforts to improve the implementation of national examinations at the elementary school to high school level. SMAN 5, SMKN 6 and SMK Wisnuwardhana are examples of schools that implement UNBK in the city of Malang. The implementation of the UNBK has been running from the 2015/2016 academic year to the 2018/2019 school year and the results can be evaluated. This study uses a qualitative method. For this reason, based on the CIPP implementation evaluation model taking into account the Context (Context), Input (Input), Process (Process), and Results (Product) factors, it can be said that the implementation of UTBK in the three schools is good, it's just that there is a decrease in student scores because the questions are tWoo difficult. and sometimes the question lattice doesn't come out. The factors that influence the implementation of UTBK are environmental culture; access to technology; and the condition of the socio-economic status of the community (students).
A review of heuristic optimization techniques applied for 3D body reconstruction from anthropometric measurements
Authors:   Modeling and Simulation, Viettel High Technology Industries Corporation, Hanoi, Vietnam, et al. Tien
Published: April 2022

Reconstructing 3D human models has a variety of applications in areas such as entertainment, medical, manufacturing, and design. Reconstruction techniques are classified based on characteristics such as data input, devices used, and algorithms employed, in which using anthropometric measurements is one of the most widely used methods. Traditional methods of 3D human reconstruction from anthropometric measurements rely on technologies like Convolutional Neutral Network (CNN), and Linear Regression to generate an accurate model in a reasonable amount of time. This paper presents a picture of heuristic optimization methods to find the optimal solution in 3D body reconstructions from anthropometric measurements. In terms of output accuracy, the methods discussed in this paper have the potential to outperform CNN and similar technologies. Results are verified and validated on a real dataset to evaluate the performances of each method.
Factors influencing premenstrual syndrome in nursing students
Authors:   Nursing Department, Gyeongnam Provincial Geochang College, Gyeonnam, South Korea, Kim In Joo
Published: April 2022

The purpose of this study is to examine the menstrual attitude, resilience, and premenstrual syndrome (PMS) of nursing students, and to identify predictors of PMS in nursing students. A descriptive survey design was used in this study and 154 nursing college students enrolled in the nursing departments of universities located in D and K cities became the study participants. Data were collected through survey questionnaires and were analyzed using IBM SPSS 20.0 through mean and standard deviation, t-test, ANOVA, Pearson correlation, and stepwise regression analysis. The results showed that menstrual attitude has a negative correlation with PMS, and resilience has a positive correlation with PMS The participants’ PMS showed a positive correlation with menstrual attitude (r=.114, p=.004) and a negative correlation with resilience. In addition, factors affecting PMS in nursing students were menstrual attitude and resilience, with an explanatory power of 20.5%. In particular, resilience was identified as the key factor for predicting PMS among nursing students. Therefore, based on the study results, a nursing intervention program must be developed to effectively manage the premenstrual and postmenstrual clusters of nursing students.