bluuebunny/crossref_metadata_2025 huggingface dataset:
Theoretical Investigation on Carbazole Derivatives as Charge Carriers for Perovskite Solar Cell
Authors: M. Samrudhi B. , Idrissi Abdennacer , Bouzakraoui Said , Mane Manoj V. , Devadiga Deepak , T. N. Ahipa
Published: September 2024

The study explores carbazole‐based organic molecules as transport layers in durable perovskite solar cells, focusing on their optoelectronic and charge transfer properties. Thirteen carbazole derivatives are systematically analyzed via density functional theory (DFT) calculations to understand their structure and optoelectronic characteristics. Substituents like bromo, phenyl, thiophenyl, and pyridyl at positions 3,6‐ and 2,7‐ of carbazole were studied. Phenyl and thiophenyl substitutions lowered highest occupied molecular orbital (HOMO) energy levels, while bromo and pyridyl increased them, tuning HOMO energies from −5.45 to −6.03 eV. These energies align well with perovskite materials valence bands, with absorbance primarily below 400 nm, complementing perovskite absorption. The compounds showed high light‐harvesting efficiencies (LHEs) (0.22 to 0.94) and improved radiative lifetimes. Theoretical investigations identified most compounds as effective p‐type hole‐transport materials (HTM), except 3,6‐ and 2,7‐dithiophenyl carbazoles, which exhibited n‐type behavior due to low hole reorganization energies. Overall, the study highlights computational design's role in developing carbazole derivatives as promising charge carrier precursors for perovskite solar cells.
Clinical efficacy and safety of perampanel monotherapy as primary anti‐seizure medication in the treatment of pediatric epilepsy: A single‐center, prospective, observational study
Authors: Gu Yanxia , Li Yue , Li Wei , Chen Feng , Wu Chunfeng , Chen Jing
Published: September 2024

Objective

To assess the efficacy and safety of perampanel (PER) as primary monotherapy in patients aged 4–18 years old with epilepsy.

Methods

A single‐center, prospective, observational study was conducted from October 2021 to October 2023, to evaluate PER monotherapy's efficacy and safety as initial therapy for pediatric epilepsy. Changes in seizure frequency, safety, and retention rate were observed at 3, 6, 9, and 12 months after initiating PER primary monotherapy.

Results

A total of 124 children aged 4–15 years (mean age = 8.25 ± 2.50 years) were included in the Analysis Sets. The retention rates at 3, 6, 9, and 12 months were 88.71% (110/124), 84.68% (105/124), 78.26% (90/115), and 71.58% (68/95), respectively. Seizure freedom rates at 3, 6, 9, and 12 months were 85.45%, 79.09%, 76.24%, and 75.31%, respectively. The responder rates (≥50% but <100%) at the same endpoints were 9.09%, 14.55%, 12.87%, and 7.41%, respectively. Seizure freedom rate of PER was independent of age at PER initiation, seizure onset age, gender, baseline frequency, seizure types, and family history of epilepsy (p > 0.05) but associated with duration of treatment (p = 0.001) and maintenance dose (p = 0.022). Additionally, 124 patients were included in the safety analysis set. The overall adverse event rate was 38.71% (48/124), with irritability (19 cases, 15.32%) and dizziness (18 cases, 14.52%) being the most common adverse effects. One patient discontinued PER monotherapy within 1 month due to unbearable itching of the skin.

Significance

PER monotherapy as the primary anti‐seizure medication (ASM) for pediatric epilepsy demonstrates high efficacy and safety in real‐world clinical treatment. Patients who respond well to this drug and adhere to long‐term treatment can achieve favorable seizure control. Furthermore, patients achieving seizure freedom with a relatively lower dose can opt for the same dose as the maintenance dose.

Plain Language Summary

This study provided the efficacy and safety of PER monotherapy as the primary ASM for Chinese pediatric epilepsy. In total, 124 patients took part. The seizure freedom rates were over 70% at different observation points (OPs), along with a retention rate of 71.58% at the 12‐month OP. Most of adverse effects observed were mild to moderate.
Toxicity Risks Associated With the Beta-Blocker Metoprolol in Marine and Freshwater Organisms: A Review
Authors: Love Deirdre , Slovisky Megan , Costa Kaylie Anne , Megarani Dorothea , Mehdi Qaim , Colombo Vincent , Ivantsova Emma , Subramaniam Kuttichantran , Bowden John A. , Bisesi Joseph H. , Martyniuk Christopher J.
Published: September 2024

The detection of pharmaceuticals in aquatic ecosystems has generated concern for wildlife and human health over the past several decades. β-adrenergic blocking agents are a class of drugs designed to treat cardiovascular diseases and high blood pressure. Metoprolol is a second-generation β1-adrenergic receptor inhibitor detected in effluent derived from sewage treatment plants. Our review presents an updated survey of the current state of knowledge regarding the sources, occurrence, and toxicity of metoprolol in aquatic ecosystems. We further aimed to summarize the current literature on the presence of metoprolol in various classes of aquatic species and to consider the trophic transfer of these contaminants in marine mammals. The biological impacts of metoprolol have been reported in 20 aquatic organisms, with a primary focus on cardiac function and oxidative stress. Our review reveals that concentrations of metoprolol that cause toxicity in aquatic species are above levels that are typical of marine and freshwater environments. Future studies should investigate the effects of metoprolol at lower concentrations in aquatic organisms. Other recommendations include (1) a further focus on noncardiac endpoints, because computational assessments of currently available molecular data identify gonadotropins, vitellogenin, collagen, and cytokines as potential targets of modulation, and (2) development of adverse outcome pathways for cardiac dysfunction in aquatic species to improve our understanding of molecular interactions and outcomes following exposure. As the next generation of β-blockers is developed, continued diligence is needed for assessing environmental impacts in aquatic ecosystems to determine their potential accumulation and long-term effects on wildlife and humans. Environ Toxicol Chem 2024;43:2530–2544. © 2024 SETAC
Influence of Pesticide Application Method, Timing, and Rate on Contamination of Nectar with Systemic and Nonsystemic Pesticides
Authors: Rostán Vanesa , Wilson Patrick C. , Wilson Sandra B. , van Santen Edzard
Published: September 2024

Exposure to pesticides is one potential factor contributing to the recent loss of pollinators and pollinator diversity. Few studies have specifically focused on the relationship between pesticide management during ornamental plant production and contamination of nectar. We evaluated contamination of nectar in Salvia ‘Indigo Spires’ (Salvia longispicata M. Martens & Galeotti × S. farinacea Benth.) associated with applications of the systemic insecticide thiamethoxam, and the nonsystemic fungicides boscalid and pyraclostrobin. Applications were made at the labeled rates for the commercially available products, and we compared the influence of application method (drench vs. spray), timing (relative to flowering), and rate (low vs. high) for each pesticide. Nectar was sampled using 50-µL microcapillary tubes and analyzed by liquid chromatography–tandem mass spectrometry. The results indicate that concentrations from the spray application resulted in the least contamination of nectar with the systemic thiamethoxam, with lower concentrations occurring when thiamethoxam was applied before blooming at the lowest rate. Concentrations of thiamethoxam and its metabolite clothianidin were detected in nectar in all treatments (regardless of the method, timing, or rate of application), and ranged from 3.6 ± 0.5 ng/mL (spray-applied before blooming, low rate) to 1720.0 ± 80.9 ng/mL (drench-applied after blooming, high rate). Residues of clothianidin in nectar ranged from below quantification limits (spray-applied before blooming, low rate) to 81.2 ± 4.6 ng/mL (drench-applied after blooming, high rate). Drench applications resulted in the highest levels of nectar contamination with thiamethoxam, and exceeded published median lethal concentrations (LC50s/median lethal doses for native bees and/or honeybees in all cases). Spray treatments resulted in nectar concentrations exceeding published LC50s for some bee species. In comparison, all nonsystemic treatments resulted in concentrations much lower than the published no-observable-effect doses and sublethal toxicity values, indicating low risks of toxicity. Environ Toxicol Chem 2024;43:2616–2627. © 2024 SETAC
Gross to gourmet: A social media analysis of Naked Clams as a sustainable delicacy
Authors: Shipway J Reuben , Tupper Mark , Willer David F
Published: September 2024

Amidst a global food crisis, securing sustainable food sources is vital. Bivalves such as Naked Clams, historically known as shipworms, offer a promising solution due to their low environmental impact, high nutritional value, and rapid growth rates. Contrary to their image as pests, Naked Clams are the fastest growing bivalves and have various health benefits. Believed to be the world's first aquaculture species, cultivated by Aboriginal Australians 8000 years ago, they are a delicacy in Southeast Asia. Public perception of Naked Clams remains largely unexplored, hindered by their association as pests and worm‐like appearance. This study assesses the perception of Naked Clams through social media, analyzing 40 posts across Facebook, Instagram, TikTok, and YouTube, with millions of views and likes. Analysis of nearly 8000 comments revealed that public perception was split, though generally more positive than negative. Concerns included appearance, potential religious dietary conflicts, and the risk of parasites, which can be addressed with educational campaigns. Importantly, 84% of commenters who tried Naked Clams reported liking them. Naked Clams are noted for their high protein content, nutrient density, and health benefits, and are enjoyed in diverse culinary forms, from traditional raw dishes, to battered calamari‐style street foods, to innovative recipes like Naked Clam ice cream. This study highlights the untapped potential of Naked Clams in global diets and calls for further exploration into moving Naked Clams from “gross to gourmet.”
A review on advancements in emerging processing of whey protein: Enhancing functional and nutritional properties for functional food applications
Authors: Kheto Ankan , Adhikary Uttam , Dhua Subhamoy , Sarkar Ayan , Kumar Yogesh , Vashishth Rahul , Shrestha Bibek Bahadur , Saxena D. C.
Published: September 2024

Whey protein (WP) isolates are widely used in food products because they improve protein content, functional properties, and health benefits. It has been observed that WP can form conjugates with essential micronutrients, improving their dietary delivery and biological availability. WP and its derived bioactive peptides have potential health benefits in preventing chronic diseases. However, the off‐flavor and bitter peptides of WP are limiting factors that can be used in the food and beverage industries. Emerging innovative processing technologies, such as high hydrostatic pressure, ultrasonication, and extrusion, improve WP gelling ability, gel strength, and storage stability, providing high‐quality and healthy functional products. The integration of technological advancements into WP‐loaded fortified food products (FFPs) has increased the uptake rate of bioactive compounds, resulting in increased bioavailability and bioaccessibility in the human body. Furthermore, WP‐based FFPs treated with advanced thermal and nonthermal processing techniques possess better rheological properties, expansion ratios, and textural properties. Therefore, WP would be a promising and sustainable ingredient for developing stable functional foods. This review explores recent advancements in the processing technologies of WP, emphasizing their role in enhancing its bioavailability and functional properties for different food applications.
Deep learning techniques for Alzheimer's disease detection in 3D imaging: A systematic review
Authors: Zia‐ur‐Rehman  , Awang Mohd Khalid , Ali Ghulam , Faheem Muhammad
Published: September 2024

Background and Aims

Alzheimer's disease (AD) is a degenerative neurological condition that worsens over time and leads to deterioration in cognitive abilities, reduced memory, and, eventually, a decrease in overall functioning. Timely and correct identification of Alzheimer's is essential for effective treatment. The systematic study specifically examines the application of deep learning (DL) algorithms in identifying AD using three‐dimensional (3D) imaging methods. The main goal is to evaluate these methods' current state, efficiency, and potential enhancements, offering valuable insights into how DL could improve AD's rapid and precise diagnosis.

Methods

We searched different online repositories, such as IEEE Xplore, Elsevier, MDPI, PubMed Central, Science Direct, ACM, Springer, and others, to thoroughly summarize current research on DL methods to diagnose AD by analyzing 3D imaging data published between 2020 and 2024. We use PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines to ensure the organization and understandability of the information collection process. We thoroughly analyzed the literature to determine the primary techniques used in these investigations and their findings.

Results and Conclusion

The ability of convolutional neural networks (CNNs) and their variations, including 3D CNNs and recurrent neural networks, to detect both temporal and spatial characteristics in volumetric data has led to their widespread use. Methods such as transfer learning, combining multimodal data, and using attention procedures have improved models' precision and reliability. We selected 87 articles for evaluation. Out of these, 31 papers included various concepts, explanations, and elucidations of models and theories, while the other 56 papers primarily concentrated on issues related to practical implementation. This article introduces popular imaging types, 3D imaging for Alzheimer's detection, discusses the benefits and restrictions of the DL‐based approach to AD assessment, and gives a view toward future developments resulting from critical evaluation.
Sexual function of overweight pregnant women with gestational diabetes mellitus: A cross‐sectional study
Authors: Peivandi Saloumeh , Habibi Ali , Hosseini Seyed H. , Khademloo Mohammad , Motamedi‐Rad Elham
Published: September 2024

Background and Aims

Overweight and obesity are on the rise worldwide and may affect female sexual function. The aim of this study was to investigate the relationship between sexual function in normal and overweight pregnant women with gestational diabetes mellitus (GDM).

Methods

This cross‐sectional study was conducted in overweight and normal‐weight pregnant women with GDM in Sari, Iran. Data were collected from 2018 to 2021. The demographic data collected from the participants included age, educational level, occupation, gestational age, duration of marriage, number of births, place of residence (city or village), private house, private bedroom, and insurance status. The General Health Questionnaire, Female Sexual Function Index (FSFI), and Enriched Marital Satisfaction questionnaires were used to assess mental health, sexual functioning, and marital satisfaction, respectively.

Results

The study included 200 women with GDM. The mean age of the participants was 29.75 (SD = 4.40) years. Among pregnant women with GDM, 56.50% of them had sexual dysfunction based on FSFI. The mean FSFI score in pregnant women with GDM was 25.60 (SD = 3.61). Among the participants, 50.00% had normal body mass index (BMI). There was no significant difference between BMI status and total sexual function score (p > 0.05). The multivariate analysis revealed that marital satisfaction (β = 0.41, p < 0.001) and BMI status (β = −0.15, p = 0.002) were the only factors significantly associated with overall sexual function, explaining 27% of the variance in the total FSFI score.

Conclusion

The results of this study showed that there was no significant relationship between sexual dysfunction and obesity in GDM. Considering that the research in this area is very limited and the negative effects of obesity and GDM have been confirmed in many areas, including sexual desire disorder, necessary planning should be done to control these factors.
Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy
Authors: Bonomi Philip , Moudgalya Hita , Gomez Sandra L. , Shah Palmi , Basu Sanjib , Batus Marta , Martinka Levi B. , Abdelkader Ahmed , Tzameli Iphigenia , Cobain Sonia , Collins Susie , Keliher Edmund J. , Breen Danna M. , Calle Roberto A. , Fidler Mary Jo , Borgia Jeffrey A.
Published: September 2024

Background

The primary objective of this study was to assess the frequency of body composition increases and their relationships to changes in body weight in two cohorts of real world, treatment‐naïve, advanced non‐small cell lung cancer (NSCLC) patients. One cohort received the current standard of care (CSOC), which consisted of immunotherapy and newer chemotherapy regimens, and the other cohort was treated with the former standard of care (FSOC), consisting only of older platinum‐containing regimens.

Methods

CSOC (n = 106) and FSOC (n = 88) cohorts of advanced NSCLC patients were included in this study. Weights were collected at each clinical visit, and body composition analysis from routine chest computed tomography via automated segmentation software assessed at baseline and at 6 and 12 weeks. Standard statistical methods were used to calculate relationships between changes in weight and in body composition.

Results

The CSOC cohort contained 106 stage IV NSCLC patients treated between 16/12/2014 and 22/10/2020 while the FSOC cohort contained 88 stage III/IV NSCLC patients treated between 16/6/2006 and 18/11/2014. While each cohort exhibited decreases in median weight, body mass index (BMI), mean skeletal muscle index (SMI) and subcutaneous adipose tissue index (SATI) at the 6 and 12 week time points, a subset of patients experienced increases in these parameters. Using a threshold of ≥2.5% increase for weight, BMI, SMI, and SATI at the 12 week time point, both cohorts showed similar (20.5% and 27.3%) increases in these parameters. With a cut point of ≥5% increase at 12 weeks follow‐up, 8.0% to 25.0% of the patients gained ≥5% in weight, BMI, SMI and SATI. Comparing these results in each cohort showed no significant differences. Pearson coefficients for weight change related to changes in SMI and SATI at 6 and 12 weeks ranged from 0.31 to 0.58 with all P values <0.02. Pearson coefficients for weight change at 12 weeks related to changes in VATI and IMATI ranged from 0.26 to 0.47 with all P values <0.05. Comparison of Pearson coefficients for each cohort showed no significant differences.

Conclusions

Although decreases in median weight, BMI, SMI and SATI were observed in both cohorts, similar percentage of patients in each cohort experienced increases in these parameters. These findings, plus the positive correlations between longitudinal measurements of weight, muscle mass and adipose tissue, indicate that weight gain in these patients involves increases in both muscle mass and adipose tissue. Upon validation, these findings could have implications for clinical trial design and for translational research in cancer cachexia.
Accuracy of supervised measurement of fetal weight in a residency program
Authors: Brambila‐Rodríguez Ana Fabianne , Villalobos Guillermo De La Cruz , Domínguez‐Rodríguez Juan Joel , Oviedo‐Cruz Héctor
Published: September 2024

Objectives

To evaluate the accuracy of ultrasound estimates of fetal weight made by residents.

Methods

A cross‐sectional study was conducted on consecutive pregnancies attended in an obstetric ward. All participants provided their consent to participate. Inclusion criteria were singleton pregnancies with ultrasound evaluation and delivery within 14 days. Congenital abnormalities and stillbirths were excluded. Ultrasound scans were performed by two residents, one observer per subject, following standardized methodology and supervised by senior staff. Fetal weight was calculated using the four‐parameter Hadlock 1985 formula. Birth weight was measured using a standard clinical scale. Bland–Altman and mixed‐effects analyses were performed.

Results

In a 6‐month period, 95 gestations were recruited at 30–41 weeks, and birth weights ranged from 1200 to 4080 g. The bias between methods was −28 g (CI95%, −74 to 18) with 95% limits of agreement of ±440 g. The 95% deviation between methods was of ±16%. Parity had the most significant effect on the bias between methods; operator and maternal weight had no significant effect.

Conclusions

Supervised measurement of fetal weight by residents demonstrated high accuracy. Parity bias may be associated with visceral fat deposition independent of maternal weight gain. A methodology for medical evaluation is presented.
Volumetric changes of the enteric nervous system under physiological and pathological conditions measured using x‐ray phase‐contrast tomography
Authors: Peruzzi Niccolò , Eckermann Marina , Frohn Jasper , Salditt Tim , Ohlsson Bodil , Bech Martin
Published: September 2024

Background and Aim

Full‐thickness biopsies of the intestinal wall may be used to study and assess damage to the neurons of the enteric nervous system (ENS), that is, enteric neuropathy. The ENS is difficult to examine due to its localization deep in the intestinal wall and its organization with several connections in diverging directions. Histological sections used in clinical practice only visualize the sample in a two‐dimensional way. X‐ray phase‐contrast micro‐computed tomography (PC‐μCT) has shown potential to assess the cross‐sectional thickness and volume of the ENS in three dimensions (3D). The aim of this study was to explore the potential of PC‐μCT to evaluate its use to determine the size of the ENS.

Methods

Full‐thickness biopsies of ileum obtained during surgery from five controls and six patients clinically diagnosed with enteric neuropathy and dysmotility were included. Punch biopsies of 1 mm in diameter and 1 cm in length, from an area containing myenteric plexus, were extracted from paraffin blocks, and scanned with synchrotron‐based PC‐μCT without any staining.

Results

The microscopic volumetric structure of the neural tissue (consisting of both ganglia and fascicles) could be determined in all samples. The ratio of neural tissue volume/total tissue volume was higher in controls than in patients with enteric neuropathy (P = 0.013). The patient with the longest disease duration had the lowest ratio.

Conclusion

The assessment of neural tissue can be performed in an objective, standardized way, to ensure reproducibility and comparison under physiological and pathological conditions. Further evaluation is needed to examine the role of this method in the diagnosis of enteric neuropathy.
Absolute Quantification of Glutathione Using Top‐Hat Optics for IR‐MALDESI Mass Spectrometry Imaging
Authors: Bruce Emily R. , Kibbe Russell R. , Hector Emily C. , Muddiman David C.
Published: September 2024

Infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) uses an infrared laser to desorb neutral biomolecules with postionization via ESI at atmospheric pressure. The Gaussian profile of the laser with conventional optics results in the heating of adjacent nonablated tissue due to the energy profile being circular. A diffractive optical element (DOE) was incorporated into the optical train to correct for this disadvantage. The DOE produces a top‐hat beam profile and square ablation spots, which have uniform energy distributions. Although beneficial to mass spectrometry imaging (MSI), it is unknown how the DOE affects the ability to perform quantitative MSI (qMSI). In this work, we evaluate the performance of the DOE optical train against our conventional optics to define the potential advantages of the top‐hat beam profile. Absolute quantification of glutathione (GSH) was achieved by normalizing the analyte of interest to homoglutathione (hGSH), spotting a dilution series of stable isotope labeled glutathione (SIL‐GSH), and analyzing by IR‐MALDESI MSI with either the conventional optical train or with the DOE incorporated. Statistical comparison indicates that there was no significant difference between the quantification of GSH by the two optical trains as evidenced by similar calibration curves. Results support that both optical trains can be used for qMSI without a change in the ability to carry out absolute quantification but providing the benefits of the top‐hat optical train (i.e., flat energy profile and square ablation spots)—for future qMSI studies.
Unravelling the performance of atmospheric radiative transfer schemes in the simulation of mean surface climate in Central Africa using the RegCM5 climate model
Authors: Djouka Kankeu E. E. , Komkoua Mbienda A. J. , Choumbou P. C. , Guenang G. M. , Demanou Koudjou G. P. , Mbane Mbioule C.
Published: September 2024

The theory of radiative transfer in the atmosphere is crucial in the study of climate, because radiative exchanges are at the origin of the atmospheric dynamics. It is therefore important to evaluate this phenomenon in order to be able to take effective measures to tackle climate change. The objective of this work is to evaluate the capability of the RegCM5 climate model to reproduce radiative transfer over Central Africa. The analysis is carried out over a 10‐year period, from January 2002 to December 2011 preceded by 1 year as spin‐up. RegCM5 model were evaluated using the ERA5 dataset for the radiative transfer parameters (the shortwave radiation [SWR], longwave radiation [LWR], cloud cover [CLT], surface albedo [ALB] and surface temperature), as well as CHIRPS dataset for precipitation. Three subregions were identified for more specific analysis of the model, namely the Sahel, Congo basin and Cameroon highlands. Two radiative schemes were used: the radiative scheme of the community climate model (CCM) and Rapid Radiative Transfer Model (RRTM). The assessment of radiative transfer parameters was carried out by examining their seasonal variability and annual cycles using data from two RegCM5 experiments, RegCM5‐CCM3 and RegCM5‐RRTM. Before this assessment, a sensibility analysis to convective schemes carried out with the default RegCM5 radiative scheme (CCM3) shows that Grell scheme with Arakawa and Shulber closure is the best scheme to represent key radiation parameters (LWR and SWR). This convective scheme is therefore used for assessing the two Radiative transfer schemes. Results show that both RegCM5 experiments simulate relatively well the variables linked to radiative transfer for the four seasons of the year. However, RegCM5 with RRTM as radiative scheme depicts better performance over all subregions and seasons, suggesting that the choice of this scheme does not depend on land cover, topography and rainfall regimes in a complex region such as Central Africa.
Comprehensive investigation on the flavor difference in five types of tea from JMD (Camellia sinensis ‘Jinmudan’)
Authors: Tang Mengting , Liao Xiansheng , Xu Mengting , Zhang Jianming , Wu Xianshou , Wei Mingxiu , Jin Shan , Zheng Yucheng , Ye Naixing
Published: September 2024

BACKGROUND

Jinmudan (JMD) is a high‐aroma variety widely cultivated in China. The current study primarily focuses on the key volatile metabolites in JMD black and oolong teas, and investigates the impact of processing technologies on the aroma quality of JMD tea. However, few studies have explored the suitability of JMD for producing a certain type of tea or the characteristic quality differences among various JMD teas using multivariate statistical analysis methods.

RESULTS

The principal volatile metabolites contributing to the floral quality of JMD tea are linalool, geraniol, indole and phenethyl alcohol. In JMD black tea (BT), the key volatile metabolites include methyl salicylate, geraniol, (E)‐β‐ocimene and phenethyl alcohol. In JMD oolong tea (OT), the key volatile metabolites include indole, linalyl valerate and phenethyl alcohol. In JMD yellow tea (YT), the key volatile metabolites include methyl salicylate, geraniol and terpinolene. In JMD white tea (WT), the key volatile metabolites include methyl salicylate, geraniol and terpinolene. In JMD green tea (GT), the key volatile metabolites include (E)‐β‐ocimene, indole and geraniol. Comparative analysis and KEGG pathway enrichment analysis revealed that flavonoid biosynthesis is the primary metabolic pathway responsible for the taste differences among various tea types. GT exhibited higher levels of phloretin, dihydromyricetin and galangin. The contents of vitexin, tricetin in YT were relatively higher. The contents of aromadendrin and naringenin in BT were higher, while OT contained higher levels of kaempferol. Additionally, WT showed higher contents of 3‐O‐acetylpinobanksin and 3,5,7‐pinobanksin.

CONCLUSION

This study explained the reasons for the quality differences of different JMD tea and provided a reliable theoretical basis for the adaptability of JMD tea. © 2024 Society of Chemical Industry.
Organization of A2‐Type Active Composite Nanorods
Authors: Li Fenglin , Yang Yajing , Wen Zhendong , Sun Dayin , Ye Yilan , Yang Zhenzhong
Published: September 2024

Nanorods as building blocks are promising to construct functional superstructures. A paramagnetic Fe3O4‐based composite nanorod is large‐scale synthesized from the poly(2‐vinylpyridine) (P2VP) side chain grafted polymer bottlebrush by electrostatics‐mediated intramolecular crosslinking via metallic coordination. Ultrasonication‐assisted fracturing of the composite nanorod derives the corresponding A2‐type composite nanorods whose two ends are active with the metallic coordinated P2VP exposed. The active ends are prone to connection upon feeding ligands (acidic or alkaline) or metallic ions to trigger the organization of the A2‐type nanorods toward functional superstructures. Their microstructure is tunable from linear nanowires to branches, which is dependent on the valent state of the assistant chemicals. The report method is easily extended to derive a family of A2‐type active nanorods with varied compositions and functions which are capable to organize functional nanomaterials with tunable microstructure.
Two geometrical invariants for three‐dimensional systems
Authors: Liu Aimin , Liu Yongjian , Lu Xiaoting
Published: September 2024

The subject of KCC theory is a second‐order ordinary differential equation, it is sometimes difficult to convert the high dimensional system into an equivalent second‐order system because of the analytical requirements of KCC theory. By means of the Euler‐Lagrange extension of a flow on a Riemannian manifold, this paper gives five geometric invariants of some three‐dimensional systems with great convenience, and focus on the analysis of two of them. The results show that the hyperbolic equilibria corresponding to the seven standard forms of three‐dimensional linear systems are Jacobi unstable. This is completely different from what we got before in two‐dimensional systems, where Jacobi stable and Jacobi unstable correspond to focus and node, respectively. All equilibria of classical Lü chaotic system and Yang‐Chen chaotic system are Jacobi unstable. Meanwhile, in three‐dimensional linear case, the torsion tensors at any point of the trajectory are identically equal to zero, but the two nonlinear systems have nonzero torsion tensors components.
Long‐term beam output stability of an accelerator‐based boron neutron capture therapy system
Authors: Komori Shinya , Takeuchi Akihiko , Kato Ryohei , Yamazaki Yuhei , Motoyanagi Tomoaki , Narita Yuki , Kato Takahiro , Takai Yoshihiro
Published: September 2024

Background

Accelerator‐based boron neutron capture therapy (AB‐BNCT) systems are becoming commercially available and are expected to be widely used in hospitals. To ensure the safety of BNCT, establishing a quality assurance (QA) program and properly managing the stability of the system are necessary. In particular, a high level of beam output stability is required to avoid accidents because beam output is a major factor in patient dose. However, no studies have analyzed the long‐term beam output stability of AB‐BNCT systems.

Purpose

This study aimed to retrospectively analyze the long‐term stability of the beam output by statistical process control (SPC) based on the QA results over 3 years.

Methods

The data analyzed are the results of daily QA (DQA) and weekly QA (WQA) in an AB‐BNCT system and were taken between June 2020 and September 2023. The evaluation of the stability of the beam output was based on the reaction rate between gold and neutrons calculated using the activation foil method using a gold foil. In DQA, which can be performed in a short time, the gold foil was applied directly to the beam irradiation aperture in air. In WQA, measurements were performed at the phantom surface, 2‐cm depth, and 6‐cm depth using a dedicated water phantom. The acquired data were retrospectively analyzed by individuals and a moving range chart (I‐MR chart), exponentially weighted moving average control chart (EWMA chart), and several process capability indexes (PCIs).

Results

Over 99% of the DQA I‐MR chart results were within control limits, whereas the WQA I‐MR chart results showed that 1.8%, 4.1%, and 2.0% of the measurements exceeded the control limits at the surface, 2‐cm depth, and 6‐cm depth, respectively. The variation in the reaction rate of the gold foil before and after the replacement of the target was <0.5%. The EWMA chart results revealed no significant beam output drift for either DQA or WQA. Most measured data were normal based on the results of the Anderson–Darling test and met the requirements for PCI evaluation; most PCI values were >1.0; however, the Cpmk of DQA and the 2‐ and 6‐cm depth WQAs between August 2021 and November 2022 in treatment course 2 were 0.83, 0.77, and 0.87, respectively, which were <1.0.

Conclusions

The long‐term stability of beam output was confirmed using SPC in an AB‐BNCT system. The results of the control chart revealed no significant variation or drift in the beam output, and the quantitative evaluation using PCI revealed high stability. A routine QA program will enable us to provide safe BNCT.
The impact of genotype on age at loss of ambulation in individuals with Duchenne muscular dystrophy treated with corticosteroids: A single‐center study of 555 patients
Authors: Zygmunt Alexander , Wong Brenda , Moon David , Horn Paul , Rathbun Richard , Lambert Joshua , Bange Jean , Rybalsky Irina , Reebals Lisa , Tian Cuixia
Published: September 2024

Introduction/Aims

Studies have demonstrated that certain genotypes in Duchenne muscular dystrophy (DMD) have milder or more severe phenotypes. These studies included individuals treated and not treated with corticosteroids and multiple sites with potentially varying standards of care. We aimed to assess genotype–phenotype correlations for age at loss of ambulation (LoA) in a large cohort of individuals with DMD treated with corticosteroids at one center.

Methods

In this retrospective review of medical records, encounters were included for individuals diagnosed with DMD if prescribed corticosteroids, defined as daily deflazacort or prednisone or high‐dose weekend prednisone, for 12 consecutive months. Encounters were excluded if the participants were taking disease‐modifying therapy. Data were analyzed using survival analysis for LoA and Fisher's exact tests to assess the percentage of late ambulatory (>14 years old) individuals for selected genotypes.

Results

Overall, 3948 encounters from 555 individuals were included. Survival analysis showed later age at LoA for exon 44 skip amenable (p = .004), deletion exons 3–7 (p < .001) and duplication exon 2 (p = .043) cohorts and earlier age at LoA for the exon 51 skip amenable cohort (p < .001) when compared with the rest of the cohort. Individuals with deletions of exons 3–7 had significantly more late ambulatory individuals than other cohorts (75%), while those with exon 51 skip amenable deletions had significantly fewer (11.9%) compared with other cohorts.

Discussion

This confirms previous observations of genotype–phenotype correlations in DMD and enhances information for trial design and clinical management.
Measurement of mid‐upper arm circumference to screen for childhood malnutrition: General applicability and use in special populations
Authors: Becker Patricia , Abdel‐Rahman Susan , Nemet Dan , Marino Luise V. , Noritz Garey , Fisberg Mauro , Beretich Kaitlan
Published: September 2024

Since the development of consensus‐recommended indicators for pediatric malnutrition in 2014, screening and diagnosis of pediatric malnutrition have improved, but the indicators are not always used; malnutrition continues to be underdiagnosed in some community and healthcare settings. In particular, mid‐upper arm circumference (MUAC) is underused as a screening indicator for pediatric malnutrition, despite its unique advantages and usefulness in several clinical situations. In December 2022, a scientific roundtable was held to bring together several experts in pediatric malnutrition. One of the goals of the scientific roundtable was to discuss the clinical use of anthropometric measures as screening tools for pediatric malnutrition status, with a focus on the use of MUAC. This article arose from that event and is intended as an educational tool to aid clinicians in implementing MUAC measurements. In addition to describing the use of MUAC as a screening tool, the article discusses several clinical situations in which MUAC is especially useful. Additionally, the article reviews practical aspects of measuring and interpreting MUAC values, provides links to additional educational resources, and briefly reviews areas in which further research is needed regarding the use of MUAC for screening of nutrition status in children.
Real‐World Evaluation of Asthma Severity Following Endoscopic Sinus Surgery in Chronic Rhinosinusitis Patients
Authors: Caballero Anyull D. B. , Candelo Estephania , Avila‐Castano Karol , Alhalabi Alaa , Donaldson Angela M.
Published: September 2024

Objective

This study aimed to evaluate the impact of endoscopic sinus surgery (ESS) on asthma severity up to 12 months after surgical intervention.

Study Design

Retrospective cohort.

Setting

Tertiary care center.

Methods

Patients with a history of asthma and Chronic Rhinosinusitis (CRS) who underwent ESS between 2013 and 2023 were included. Asthma severity was assessed according to current Global Initiative for Asthma (GINA) guidelines, classifying patients into mild, moderate, and severe based on medication requirements. Asthma severity was evaluated up to 3 months prior to ESS and 1‐year post‐ESS. Patients with aspirin‐exacerbated respiratory disease (AERD) were excluded. Statistical analysis was performed using McNemar test and Wilcoxon signed‐rank test to assess differences in asthma severity, medication doses, and number of medications.

Results

Sixty‐five patients were included, of which 44 (67.7%) had CRS with nasal polyps (CRSwNP) and 21 (32.3%) had CRS without nasal polyps (CRSsNP). No significant differences were found in asthma severity pre‐ and post‐ESS (P = .175). Similarly, no differences were found in ICS doses (P = .999), total number of prescribed medications (P = .157) or presence of exacerbations before and after ESS (P = .078). However, a significant increase in time from last rescue inhaler use was noted after ESS, increasing from a median of 6.71 to 23.1 weeks (P = .004).

Conclusion

This study is the first to assess the impact of ESS on asthma severity in a real‐world setting. Our findings suggest that ESS does not impact asthma severity classification. However, it might provide relief of asthma symptoms in the early postoperative period.
Late effects surveillance adherence among young adult childhood cancer survivors: A population‐based study
Authors: Milam Joel , Kim Yoonji , Roth Michael , Freyer David R.
Published: September 2024

Lifelong, guideline‐based monitoring for late effects is recommended for childhood cancer survivors (CCS). We examined rates of receiving surveillance tests among at‐risk young adult CCS in a population‐based study (n = 253; 50% Hispanic/Latino; mean post‐treatment interval 14.5 years, range: 5–22). Adherence rates were 36.1%, 31.9%, and 36.4% among those indicated for cardiac (n = 119), thyroid (n = 68), and breast (n = 66) surveillance, respectively, indicating that poor surveillance among long‐term CCS is widespread. Receipt of any of these surveillance tests was positively associated with being in follow‐up care, having any health insurance (vs. none), and receiving education about need for follow‐up with surveillance (all p‐values less than .05).
Treatment outcomes in retinoblastoma and the effect of tumor topography
Authors: Kheir Wajiha J. , Slim Andre , Hadi Dalia El , Bechara Elie , Borghol Raphah , Noun Dolly , Al‐Haddad Christiane
Published: September 2024

Background

Retinoblastoma, the most common intraocular malignancy in children, has high fatality rates if untreated. It is crucial to monitor treatment effectiveness and explore factors influencing favorable outcomes. Our study aims to examine how tumor location impacts the response to standard treatments and the achievement of favorable outcomes among retinoblastoma patients, while controlling for other tumor‐related factors.

Methods

This retrospective study analyzed medical records of retinoblastoma patients from November 2012 to December 2022 enrolled in the retinoblastoma program at the Children's Cancer Center of Lebanon (established in collaboration with St.y Jude Children's Research Hospital, Memphis, TN). Data were extracted from the electronic chart reviews and operative reports of examinations under anesthesia (EUAs), and included patient's demographics, tumor characteristics (size, location), and treatment parameters (treatment type, resolution, recurrence).

Results

The study included 42 patients with retinoblastoma, with a total of 57 eyes and 115 tumors/lesions. The median age at diagnosis was 12 months (range: 2–36 months). Among the patients, 26 (61.9%) were males and 16 (38.1%) were females. A minority of patients (21.4%) presented with unilateral involvement, whereas the majority (78.6%) had bilateral involvement. The locations of retinoblastoma lesions were distributed as follows: optic nerve (4.4%), macula (19.1%), superior (16.5%), inferior (17.4%), nasal (27.8%), and temporal (14.8%). Resolution rate tended to be highest for tumors close to optic nerve and temporal lesions, but no statistical significance was attained (p = .45). Macular lesions tended to have the fastest resolution, but again not significantly (p = .5). Multiple logistic regression revealed that the odds for resolution of tumor was not significantly associated with tumor size (p = .57) or location (p = .52).

Conclusion

Location of retinoblastoma lesions was not directly associated with recurrence‐free resolution in our cohort. Further research in large retinoblastoma databases is needed to explore the association of tumor characteristics with recurrence and the need for secondary therapeutic interventions.
The dynamics of meaningful youth participation: Mapping the purpose of participation of Youth Dialogue on Internet Governance participants
Authors: Tjahja Nadia
Published: September 2024

This study investigates how youth are navigating the regional and global Internet governance spaces using the Pyramid of Participation framework as proposed by the author, which is built on Arnstein's ladder. By understanding how youth participate in these spaces, this study seeks to understand the dynamics of meaningful youth participation by using the Youth Dialogue on Internet Governance (YOUthDIG) as an exploratory case study. The findings reveal that The Pyramid of Participation outlined in this paper provides a visual framework for decision makers to reflect on where and how participants engage with the process. This Pyramid of Participation also acknowledges that when there is no meaningful participation, that participants will choose to discontinue their participation and this motivation requires reflection on where we can enhance processes and change attitudes to ensure a better informed group of stakeholders and empowered actors.
Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System
Authors: Martins Ana Sofia , Monteiro Cristina , Duarte Ana Paula
Published: September 2024

Cardiovascular diseases are the leading cause of death globally, making the use of oral anticoagulants for prevention increasingly important. Historically, warfarin has played a significant role in this context. In recent years, introduction of new oral anticoagulants, such as rivaroxaban, apixaban, dabigatran, and edoxaban, has been seen. This study evaluates the risk associated with the use of oral anticoagulants by analyzing spontaneous adverse drug reactions reported to the Portuguese Pharmacovigilance System from 2012 to 2021. The study includes 951 adverse drug reactions reports, with the majority (n = 770; 80.97%) classified as serious. Of the 770 serious adverse drug reactions reports, the most commonly reported seriousness criterion was “Clinically Important” (n = 350; 45.45%). In terms of demographics, there was a higher reporting rate among the elderly population, with a greater prevalence of females. The System Organ Class group with the highest number of adverse drug reactions was “Gastrointestinal disorders,” with the most commonly reported Preferred Term being “Gastrointestinal hemorrhage,” and dabigatran was the most frequently reported drug. In summary, oral anticoagulants have adverse drug reactions that require continuous monitoring. Accurate identification and monitorization of adverse drug reactions is an important starting point to improve drug safety in population.
On the Bulk Photovoltaic Effect in the Characterization of Strained Germanium Microstructures
Authors: Zaitsev Ignatii , Spirito Davide , Frigerio Jacopo , Chavarin Carlos Alvarado , Lüdge Anke , Lüdge Wolfgang , Giani Raffaele , Virgilio Michele , Manganelli Costanza Lucia
Published: September 2024

Strain engineering serves as an effective method for optimizing electronic and optical properties in semiconductor devices, with applications including the enhancement of optical emission in Ge and GeSn‐based devices, improvement of carrier mobility, and second harmonic generation in silicon photonics structures. Current methods for deformation characterization in semiconductors, such as X‐ray diffraction and Raman spectroscopy, often require bulky and expensive setups and are limited in vertical resolution. Consequently, techniques capable of measuring lattice strain while overcoming these drawbacks are highly desirable. This study proposes a proof of concept for a cost‐effective, compact, fast, and non‐destructive approach to probe non‐uniform strain fields and additional material properties by exploiting the bulk photovoltage effect. The method is benchmarked with an array of silicon nitride stripes deposited under varying pressure conditions on a germanium substrate. Initially, their surface strains are verified through Raman spectroscopy. The deformations are replicated in a finite element method platform by integrating mechanical simulations with deformation potential theory, thereby estimating the band edge energy landscape. Finally, the study discusses the theoretical behavior of the photovoltage signal, considering semiconductor properties, defects, doping, and deformation. The findings offer insights into the development of advanced techniques for strain and transport analysis in semiconductor materials.