bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase I trial combining plinabulin and nivolumab for metastatic NSCLC: Trial in progress.
Authors: Villanueva Nicolas , Son Klarissa , Yeh Shihfan , Jain Sonia , Eng Elaine , Lloyd Ken , Huang Lan , Mohanlal Ramon W. , Bazhenova Lyudmila
Published: July 2019

TPS128

Background: Plinabulin (Plin) is a microtubule-destabilizing agent (MDA) that inhibits the polymerization of tubulin monomers and leads to disruption of the tumor vasculature. It has been shown in clinical studies of advanced NSCLC to produce a significantly longer duration of response when combined with docetaxel versus docetaxel alone (NCT00630110). MDAs were also shown to trigger the maturation of dendritic cells and the production of pro-inflammatory cytokines, thereby enhancing T-cell proliferation. Pre-clinical studies have shown that MDAs in combination with immune checkpoint inhibitors (ICI) demonstrated a superior response rate and survival when compared to ICI alone. Nivolumab is an anti-PD-1 antibody that is FDA approved for previously treated metastatic NSCLC regardless of PD-L1 expression. We hypothesized that the combination of Plin and Nivolumab will enhance the immune response, resulting in a higher response rate and longer overall survival. Methods: This is an open label single center phase I trial. The Dose Escalation Portion (Part 1) employs a 3+3 design with dose escalation of Plin starting at 13.5mg/m2 (biologically effective dose as single agent), combined with the FDA approved dose of Nivolumab 240mg. Plin is given on days 1,8, and 15 of 28- day cycles and Nivolumab is given on days 1 and 15. The dose of Plin will be escalated to 20mg/m2, 30 mg/m2, and 40mg/m2 until the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) is determined. The Expansion Cohort (Part 2) will enroll 20 patients with NSCLC to be treated at the RP2D, including the patients who will have received this dose in Part 1. Treatment will continue until disease progression, development of unacceptable toxicity, or a protocol-defined reason for discontinuation. Eligible patients include metastatic NSCLC who have failed platinum-based doublet and regardless of prior anti-PD-1/PD-L1 antibody treatment. Part 1 is enrolling in an expanded cohort 2 due to one dose-limiting toxicity (DLT) in this group. Clinical trial information: NCT02812667.
Phase III KEYNOTE-716 study: Adjuvant therapy with pembrolizumab versus placebo in resected high-risk stage II melanoma.
Authors: Luke Jason J. , Ascierto Paolo Antonio , Carlino Matteo S. , Eggermont Alexander M. M. , Grob Jean-Jacques , Hauschild Axel , Kirkwood John M. , Long Georgina V. , Mohr Peter , Robert Caroline , Gershenwald Jeffrey E. , Poklepovic Andrew Stewart , Ross Merrick I. , Scolyer Richard A. , Yoon Charles , Anderson James R. , Ahsan Sama , Ibrahim Nageatte , Sondak Vernon K.
Published: July 2019

TPS145

Background: Adjuvant pembrolizumab showed significantly longer recurrence-free survival compared with placebo in resected stage III melanoma in the KEYNOTE-054 study [1]. KEYNOTE-716 is a randomized, placebo-controlled, multicenter phase 3 study of adjuvant pembrolizumab in patients with surgically resected high-risk stage II melanoma. Methods: Patients must be ≥12 years of age and have newly diagnosed, completely resected stage IIB/IIC cutaneous melanoma, defined by the AJCC Cancer Staging Manual, 8th edition [2] (wide excision and negative sentinel lymph node biopsy, with no evidence of distant metastasis). Patients cannot have mucosal or uveal melanoma or have received prior treatment for melanoma, including radiation, beyond resection of primary disease within 12 weeks of the start of study therapy. The study has a 2-part design. In the double-blind phase (part 1), patients will be randomly assigned 1:1 to receive pembrolizumab 200 mg for patients ≥18 years or 2 mg/kg for patients 12-17 years (maximum dose, 200 mg) or placebo every 3 weeks for 17 cycles. Stratification: 1 stratum for pediatric patients (12-17 years); 3 strata for adult patients per T stage (T3b/T4a/T4b). Study treatment will begin within 12 weeks of complete resection. Tumor imaging will be performed every 24 weeks while treatment is ongoing, at the end of treatment, every 6 months for the first 3 years off treatment, and then yearly for up to 2 years or until recurrence (up to 5 years of total imaging). Adverse events will be graded per NCI Common Terminology Criteria for Adverse Events, version 4.0. In the unblinded phase (part 2), patients with confirmed recurrence may be rechallenged (patients received pembrolizumab in part 1) or crossed over to pembrolizumab (patients received placebo in part 1). Resected local or distant recurrence or unresectable disease will be treated for an additional 17 or 35 cycles, respectively. Tumor imaging in part 2 will occur every 12 weeks while treatment is ongoing. The primary end point is recurrence-free survival; secondary end points are distant metastasis-free survival, overall survival, and safety. Approximately 954 patients will be enrolled. Clinical trial information: NCT03553836.
A phase I study evaluating COM701 in patients with advanced solid tumors.
Authors: Rasco Drew W. , Papadopoulos Kyriakos P. , Adewoye Adeboye H. , Hunter John , Ramsey Denise , ElNaggar Adam , Patnaik Amita , Vaena Daniel A.
Published: July 2019

TPS40

Background: Novel checkpoint therapies are needed for the treatment of patients who relapse/refractory to treatment with checkpoint inhibitors. COM701 is a novel first-in-class humanized IgG4 monoclonal antibody that binds with high affinity to poliovirus receptor related immunoglobulin domain containing (PVRIG) blocking its interaction with it's ligand, PVRL2. We have demonstrated in preclinical experiments that inhibition of PVRIG leads to activation of T cells in the tumor microenvironment generating an anti-tumor immune response leading to tumor growth inhibition. We hypothesize that COM701 will be safe and tolerable and demonstrate antitumor activity in pts with R/R solid tumors. Methods: NCT03667716 is an ongoing open-label first-in-human phase 1 study in pts with R/R solid tumors. The initial part of this study will evaluate the safety and tolerability of escalating doses of COM701 monotherapy IV Q3 weekly. Key Inclusion Criteria: Age ≥18 yrs, histologically or cytologically confirmed, locally advanced or metastatic solid malignancy and has exhausted all the available standard therapy or is not a candidate for the available standard therapy, ECOG performance status 0-1, prior anti-PD-1, anti-PD-L1, anti-CTLA-4, OX-40, CD137. Key Exclusion Criteria: Active autoimmune disease requiring systemic therapy in the last 2 years prior to the first dose of COM701, symptomatic interstitial lung disease or inflammatory pneumonitis, untreated or symptomatic central nervous system metastases. Primary outcome measures are the incidence of adverse events and dose-limiting toxicities (21-day DLT window), pharmacokinetics of COM701 and to identify the maximum tolerated dose and/or the recommended dose for expansion. Secondary outcome measures are to characterize the immunogenicity and preliminary antitumor activity of COM701. Study Design: Accelerated titration design consisting of single subject cohorts has been implemented for the initial cohorts. Statistical Considerations: Adverse events graded as per CTCAE v4.03, responses as per RECIST v1.1. The analyses of all study objectives will be descriptive and hypothesis generating. As of the date of this submission a third single subject dose cohort has been filled.
FPT155-001: A phase Ia/Ib study of FPT155 (CD80-FC) in patients with advanced solid tumors.
Authors: Millward Michael , Gan Hui Kong , Joshua Anthony M. , Kuo James Chun-Yen , Prawira Amy , Richardson Gary Edward , Barbee Susannah D. , Inamdar Sandeep P. , Pierce Kristen L. , Qureshi Mona , Horvath Lisa
Published: July 2019

TPS42

Background: Despite recent advances in immunotherapy, many patients with advanced solid tumors are refractory to available therapies or eventually relapse. Novel immune therapies are needed with differentiated mechanisms of action that result in improved response rates and durability across a broad range of tumors. FPT155 is a first-in-class therapeutic being developed to meet this need. FPT155 is a recombinant fusion protein composed of the extracellular domain of human CD80 fused with the Fc domain of human immunoglobulin G1. It is designed to act as a potent stimulator of anti-tumor immunity through CD28 and thereby co-stimulate T cell responses only in the presence of antigenic T cell receptor (TCR) signaling. FPT155 alone does not induce spontaneous cytokine release by primary human immune cells, in contrast to a CD28 superagonist antibody that exerts TCR stimulus-independent activity. FPT155 also blocks CTLA-4 from competing for endogenous CD80, allowing CD28 signaling to prevail in T cell activation. A murine surrogate of FPT155 is a potent inhibitor of tumor growth that induces complete tumor regression in multiple tumor models, including models that are insensitive to anti-PD1 or anti-CTLA4. Methods: The FPT155-001 study is a Phase 1a/1b open-label, multicenter, dose escalation and expansion study to evaluate the safety and tolerability of FPT155 monotherapy. Phase 1a dose escalation includes an accelerated titration design followed by a standard 3+3 design until the recommended dose for Phase 1b is determined by evaluation of all available safety, pharmacokinetic (PK), and pharmacodynamic (PD) data. Eligible patients with advanced solid tumors who are refractory to all standard therapy for their malignancy will be enrolled in Phase 1a. Phase 1b dose expansion will enroll patients with select tumor types. The primary endpoint is safety in both phases. Key secondary endpoints in Phase 1a include characterization of the FPT155 PK profile and immunogenicity. Key secondary endpoints in Phase 1b include objective response rate, duration of response, progression free survival, and disease control rate. The FPT155-001 trial opened for enrollment in October 2018 and is in progress. Clinical trial information: Submitted - awaiting registration number.
Prevalence of PD-L1 expression in first-line (1L) locally advanced/unresectable or metastatic urothelial carcinoma (UC).
Authors: Grivas Petros , Morgans Alicia K. , Lotan Yair , Gregg Jeffrey P. , Geynisman Daniel M. , Friedlander Terence W. , Agarwal Piyush K. , Tesic-Schnell Marija , Bernstein Andrew , Makari Doris , Meeks Joshua J
Published: July 2019

TPS67

Background: Treatments for 1L advanced/metastatic UC include platinum-based chemotherapy, an immune checkpoint inhibitor (ICI) or clinical trial enrollment. Not all patients benefit from, or are eligible for, specific therapies due to comorbidities and performance status. There is an urgent need for biomarker-directed strategies to enable patient selection and improve outcomes. Currently the only clinically used molecular biomarker is PD-L1 protein expression in tumor tissue. Although inconsistent and variable among assays, higher PD-L1 expression generally correlates with increased ICI response rate. Improved understanding of the prevalence and potential prognostic and/or predictive role of PD-L1 can further enhance its clinical utility and guide novel clinical trial designs. Methods: This observational study will enroll 250 patients with advanced UC prior to starting or during 1L therapy, as initiated at the discretion of participating clinicians, from 60 US community sites. The primary endpoint is prevalence of PD-L1 expression by VENTANA SP263 Assay (exact [Clopper-Pearson] 95% CI) on pre-treatment tumor tissue. Secondary endpoints include the association of pre-treatment PD-L1 expression with pre-treatment tumor tissue mutational burden (tTMB), descriptions of treatment response and outcomes (ORR based on RECIST 1.1, PFS, OS) and assessment of their correlations with PD-L1 expression. Exploratory endpoints include the association of pre-treatment tumor tissue PD-L1 with pre-treatment blood-based tumor mutational burden (bTMB), changes in circulating tumor DNA (ctDNA) levels at various timepoints, the correlation between tTMB and bTMB values, and the association of those biomarkers for outcomes of PFS and OS. Enrollment will take place over 24 months with follow-up to 30 months from study enrollment. With 250 patients, the 95% CI for 30%, 45%, and 60% observed prevalence of PD-L1 high are (24.4%, 36.1%), (38.9%, 51.2%), and (53.6%, 66.1%), respectively; the various secondary and exploratory analyses will be descriptive.
Comparison of 3 Methods to Assess Occupational Sevoflurane Exposure in Abdominal Surgeons: A Single-Center Observational Pilot Study
Authors: Herzog-Niescery Jennifer , Seipp Hans-Martin , Bellgardt Martin , Herzog Torsten , Belyaev Orlin , Uhl Waldemar , Gude Philipp , Weber Thomas P. , Vogelsang Heike
Published: July 2019

BACKGROUND:

Studies demonstrated that operating room personnel are exposed to anesthetic gases such as sevoflurane (SEVO). Measuring the gas burden is essential to assess the exposure objectively. Air pollution measurements and the biological monitoring of urinary SEVO and its metabolite hexafluoroisopropanol (HFIP) are possible approaches. Calculating the mass of inhaled SEVO is an alternative, but its predictive power has not been evaluated. We investigated the SEVO burdens of abdominal surgeons and hypothesized that inhaled mass calculations would be better suited than pollution measurements in their breathing zones (25 cm around nose and mouth) to estimate urinary SEVO and HFIP concentrations. The effects of potentially influencing factors were considered.

METHODS:

SEVO pollution was continuously measured by photoacoustic gas monitoring. Urinary SEVO and HFIP samples, which were collected before and after surgery, were analyzed by a blinded environmental toxicologist using the headspace gas chromatography-mass spectrometry method. The mass of inhaled SEVO was calculated according to the formula mVA = cVA·

JOURNAL/asag/04.03/00000539-202008000-00031/inline-graphic1/v/2023-07-21T062418Z/r/image-tiff

·t·ρ VA aer. (mVA: inhaled mass; cVA: volume concentration;

JOURNAL/asag/04.03/00000539-202008000-00031/inline-graphic2/v/2023-07-21T062418Z/r/image-tiff

: respiratory minute volume; t: exposure time; and ρ VA aer.: gaseous density of SEVO). A linear multilevel mixed model was used for data analysis and comparisons of the different approaches.

RESULTS:

Eight surgeons performed 22 pancreatic resections. Mean (standard deviation [SD]) SEVO pollution was 0.32 ppm (0.09 ppm). Urinary SEVO concentrations were below the detection limit in all samples, whereas HFIP was detectable in 82% of the preoperative samples in a mean (SD) concentration of 8.53 µg·L−1 (15.53 µg·L−1; median: 2.11 µg·L−1, interquartile range [IQR]: 4.58 µg·L−1) and in all postoperative samples (25.42 µg·L−1 [21.39 µg·L−1]). The mean (SD) inhaled SEVO mass was 5.67 mg (2.55 mg). The postoperative HFIP concentrations correlated linearly to the SEVO concentrations in the surgeons’ breathing zones (β = 216.89; P < .001) and to the calculated masses of inhaled SEVO (β = 4.17; P = .018). The surgeon’s body mass index (BMI), age, and the frequency of surgeries within the last 24 hours before study entry did not influence the relation between HFIP concentration and air pollution or inhaled mass, respectively.

CONCLUSIONS:

The biological SEVO burden, expressed as urinary HFIP concentration, can be estimated by monitoring SEVO pollution in the personnel’s individual breathing zone. Urinary SEVO was not an appropriate biomarker in this setting.
The many facets of neuropathic arthropathy
Authors: Chan R L S , Chan C H , Chan H F , Pan N Y
Published: July 2019

Neuropathic arthropathy, also known as Charcot arthropathy, refers to progressive and occasionally rapid joint destruction that results from underlying disorders of the nervous system. This pictorial essay aims to illustrate various radiologic findings in neuropathic arthropathy using various examples in the upper and lower limbs and in the spine. Pearls for radiologic diagnosis, clinical differential considerations and possible complications are discussed individually for each joint. MR imaging techniques for differentiating infection and neuropathic arthropathy are explained with examples. Management issues are outlined.
Total skin electron beam therapy rationalization and utility of in vivo dosimetry in a high-volume centre
Authors: Misson-Yates Sarah , Naeem Marium , Palmer Isabel , Holden Eleanor , Hedley Owen , McGovern Mark , Morris Stephen , Greener Anthony G
Published: July 2019

Objective:

This paper reports on the rationalization of a substantial pool of in vivo dosimetry (IVD) data from patients treated with total skin electron beam therapy (TSEBT) and the application of this to verify the accurate delivery of TSEBT when changing linac manufacturer.

Methods:

Thermoluminescent dosimeter IVD data from 149 patients were analyzed comparing the population mean and standard deviation for each site. The number of sites required to confirm the prescribed dose were reviewed considering both dosimetric and clinical relevance. The reduced sites were then used to assess the continued dosimetric accuracy on new equipment and the results were compared statistically using the Mann–Witney test.

Results:

The trunk dose measurement points were reduced from nine to six and five extra trunk sites were identified and reviewed clinically prior to removal. Following change in manufacturer the trunk dose points showed no statistically significant change and confirmed that patients had received within 1.3% of the intended mean trunk dose using both delivery methods. A statistically significant change in 4 out of the 13 extra trunk sites was seen following the move to the new centre. However, all but one site showed a change of less than 1 standard deviation.

Conclusion:

The total number of measurement points per patient were reduced from 27 to 19 which constituted a 25% saving in preparation and read out. Accurate delivery of prescribed dose was confirmed following measurement point reduction for treatments delivered on linacs from two different manufacturers.

Advances in knowledge:

Proven methodology for rationalization of IVD measurements for TSEBT
Comprehensive in vivo identification of the c-Myc mRNA protein interactome using HyPR-MS
Authors: Spiniello Michele , Steinbrink Maisie I. , Cesnik Anthony J. , Miller Rachel M. , Scalf Mark , Shortreed Michael R. , Smith Lloyd M.
Published: July 2019

Proteins bind mRNA through their entire life cycle from transcription to degradation. We analyzed c-Myc mRNA protein interactors in vivo using the HyPR-MS method to capture the crosslinked mRNA by hybridization and then analyzed the bound proteins using mass spectrometry proteomics. Using HyPR-MS, 229 c-Myc mRNA-binding proteins were identified, confirming previously proposed interactors, suggesting new interactors, and providing information related to the roles and pathways known to involve c-Myc. We performed structural and functional analysis of these proteins and validated our findings with a combination of RIP-qPCR experiments, in vitro results released in past studies, publicly available RIP- and eCLIP-seq data, and results from software tools for predicting RNA–protein interactions.
Έρευνα αξιολόγησης εκπαιδευτικού υλικού περιβαλλοντικής εκπαίδευσης ενηλίκων. Μία μελέτη περίπτωσης
Authors: Γρίλλια Παναγιώτα-Μαρία , Δασκολιά Μαρία
Published: July 2019

Το παρόν άρθρο παρουσιάζει τη μελέτη περίπτωσης μιας έρευνας αξιολόγησης εκπαιδευτικού υλικού περιβαλλοντικής εκπαίδευσης ενηλίκων, η οποία σχεδιάστηκε και διενεργήθηκε στο πλαίσιο του ερευνητικού έργου «Αειφόρος Τουριστική Ιστιοπλοϊκή Περιήγηση». Ο σχεδιασμός, η ανάπτυξη και αξιολόγηση του υλικού βασίστηκαν σε μια θεώρηση που επιχειρεί να ορίσει με νέο τρόπο τα κριτήρια ποιότητας και αποτελεσματικότητας, δίνοντας έμφαση στο πλαίσιο υλοποίησης του προγράμματος. Υιοθετήθηκε η προσέγγιση της εξελικτικής διαμορφωτικής αξιολόγησης μέσα από μια σπειροειδή πορεία ανατροφοδότησης του σχεδιασμού του εκπαιδευτικού υλικού, που στο πλαίσιο μιας εποικοδομιστικής θεώρησης δίνει προτεραιότητα σε συνεργατικές και αναστοχαστικές διαδικασίες ενώ είναι προσανατολισμένη στη χρηστικότητα του όλου εγχειρήματος. Για τη συλλογή των δεδομένων χρησιμοποιήθηκαν συζητήσεις σε ομάδες εστίασης και επακόλουθη έρευνα επισκόπησης με τη χρήση ερωτηματολογίου. Τα αποτελέσματα της έρευνας επιβεβαίωσαν σε μεγάλο βαθμό τις επιλογές της ερευνητικής ομάδας με άξονες τα κριτήρια σχεδιασμού του εκπαιδευτικού υλικού, ενώ οι αμφιβολίες που εκφράστηκαν σε σχέση με συγκεκριμένα σημεία/ διαστάσεις του υλικού οδήγησαν σε διορθωτικές παρεμβάσεις.
Η ελληνική εκπαιδευτική πολιτική για τη μετάβαση από την Περιβαλλοντική Εκπαίδευση στην Εκπαίδευση για την Αειφόρο Ανάπτυξη
Authors: Τίγκας Ιωάννης , Φλογαΐτη Ευγενία
Published: July 2019

Ακολουθώντας τη γραμμή της εξέλιξης που διαγράφει διεθνώς η Εκπαίδευση για την Αειφόρο Ανάπτυξη (ΕΑΑ), διαπιστώνεται η διαμόρφωση μιας θεωρητικής αλλά και πραγματικής τάσης για βαθύτερους διαδοχικούς μετασχηματισμούς των εκπαιδευτικών συστημάτων, ώστε αυτή να καταστεί βασικός πυλώνας τους ή ακόμα και επίκεντρό τους. Ο σχεδιασμός και η εφαρμογή των αλλαγών αυτών είναι ζήτημα πολιτικής. Η μελέτη που παρουσιάζεται εδώ επιχειρεί μια αξιολογική προσέγγιση της μεταρρυθμιστικής δυναμικής που παρουσιάζουν οι σχετικές ελληνικές εκπαιδευτικές πολιτικές. Η έρευνα βασίστηκε στις διαδικασίες ανάλυσης περιεχομένου των αντίστοιχων θεσμικών κειμένων, με κύριο εργαλείο τον κώδικα κριτηρίων που προτείνει ο μελετητής Stephen Sterling και ονομάζεται μοντέλο C. Τα συμπεράσματα συνοψίζονται στη διαπίστωση ότι δεν υπάρχει εναρμόνιση της ελληνικής εκπαιδευτικής πολιτικής με τη διεθνή τάση. Ειδικότερα διαπιστώνεται ότι η θεματολογία των πολιτικών, από το 1990 έως την άνοιξη του 2016, περιορίζεται στο πλαίσιο που διαμορφώθηκε από τις αρχικές ανάγκες της Περιβαλλοντικής Εκπαίδευσης (ΠΕ), η ορολογία που υιοθετείται δεν ανανεώνεται ώστε να παραπέμπει στην ΕΑΑ και, κυρίως, συμπεραίνεται ότι η ελληνική εκπαιδευτική πολιτική για την ΠΕ και την ΕΑΑ αδυνατεί να συμβάλει καθοριστικά στη γενικότερη αναδιοργάνωση του εκπαιδευτικού συστήματος.
Elementos para la relación entre cultura organizacional y estrategia
Authors: Mendez Alvarez Carlos Eduardo
Published: July 2019

Este trabajo tiene como objetivo identificar mediante el análisis conceptual  los elementos que permiten  correlacionar la cultura y estrategia en la organización.  Mediante una matriz de impacto cruzado, establece relaciones y  las sustenta con el propósito de señalar que la cultura es fundamental para la estrategia. Se  fundamenta en la consulta bibliográfica de los conceptos planteados  señalando 112 referencias de uno o más  autores. Mediante la síntesis de los resultados obtenidos cumple con el objetivo propuesto y construye la matriz de relación que se constituye en el aporte  a lectores interesados en este tema. Desde la perspectiva sociológica y de la  administración explica y sustenta la relación en cada elemento identificado. Permite concluir por la relación establecida  que  la Cultura Organizacional actúa como condición para que la estrategia cumpla su propósito.
Using Conditional Restricted Boltzmann Machines to Model Complex Consumer Shopping Patterns
Authors: Xia Feihong , Chatterjee Rabikar , May Jerrold H.
Published: July 2019

We develop and apply a model based on conditional restricted Boltzmann machines to analyze intertemporal crossproduct purchase patterns in enormous consumer purchase data sets.
EVOLUTION AND PALEOENVIRONMENTAL RECONSTITUTION OF THE SOUTHERN ZONE OF THE RIO DE JANEIRO CITY (SE BRAZIL)
Authors: Potratz Guilherme Loriato , Souza e Almeida Felipe Saliba de , Castro João Wagner de Alencar , Alves Martins Maria Virginia , Geraldes Mauro Cesar
Published: July 2019

Paleoenvironmental reconstructions in coastal environments have been carried out using indicators of relative sea level oscillation (RSL), among them, mollusk shells, beachrocks and sedimentary records. Data from eleven geological-geotechnical drilling cores (from 15 m to 30 m long) distributed along the Ipanema - Leblon coastline and on the edge of the Rodrigo de Freitas Lagoon and respective stratigraphic profiles were analyzed in this work. Eleven radiocarbon ages obtained from shell samples calibrated to eliminate the effect of reservoir were used to perform the time evolution of the study area.The obtained results allowed to identify five distinct stages on the sedimentary evolution of the Southern Zone of the Rio de Janeiro City related to the Holocene RSL variations: the first stage under continental environmental conditions, with sea level approximately 4.5 m below the current; the second stage corresponding to a paleo-cove formed due to the sea level rising; the third stage associated with the mid-Holocene maximum transgression, in which the entire study area was flooded; the fourth stage following the gradual lowering of the RSL and marked by the formation of a paleo-bay; the fifth stage corresponding to the current configuration of the coastline. EVOLUÇÃO E RECONSTITUIÇÃO PALEO-AMBIENTAL DA ZONA SUL DA CIDADE DO RIO DE JANEIRO (SE BRASIL) ResumoAs reconstruções paleoambientais em ambientes costeiros têm sido realizadas utilizando indicadores de oscilação relativa do nível do mar (NRM), entre eles, conchas de moluscos, beachrocks e registros sedimentares. Foram analisados neste trabalho, dados de onze testemunhos de perfuração geológico-geotécnica (de 15 m a 30 m de comprimento) distribuídos ao longo do litoral de Ipanema - Leblon e à beira da Lagoa Rodrigo de Freitas e respectivos perfis estratigráficos. Onze idades de radiocarbono calibradas obtidas em amostras de conchas foram utilizadas no estudo da evolução temporal da área de estudo.Os resultados obtidos permitiram identificar cinco etapas distintas da evolução sedimentar da Zona Sul da cidade do Rio de Janeiro, relacionadas com variações do NRM durante o Holoceno: a primeira etapa, sob a influência de condições ambientais continentais, está relacionada com um nível do mar aproximadamente 4,5 m abaixo do atual; a segunda etapa corresponde a uma paleo-enseada formada devido à elevação do nível do mar; o terceiro estágio associado à transgressão máxima do Holoceno médio, em que toda a área de estudo foi inundada; o quarto estágio, após o abaixamento gradual do NRM, é marcado pela formação de uma paleo-baía; a quinta etapa corresponde à configuração atual do litoral. Palavras-chave: Mudança relativa do nível do mar. Quaternário. Sedimentação Marinha. Evolução litoral. Modelo 2D.
Expediente
Authors: Correa Claudio Miranda
Published: July 2019

Expediente. Revista Maracanan, Rio de Janeiro, n. 21, maio-ago. 2019.
Use of a transforming powder dressing in the lower leg wounds of two older patients: case studies
Authors: Smith Steven P.
Published: July 2019

This report describes the use of a transforming powder dressing to treat lower leg surgical wounds occurring in two older patients. Wounds in this location are difficult and slow to heal. Both of these wounds exhibited complete granulation within two weeks of powder application and total healing in under four weeks, all while requiring no patient or nursing wound care.
New combined hormonal contraception guideline and its impact on prescribing practice
Authors: Nicol Claire
Published: July 2019

The Clinical Effectiveness Unit of the Faculty of Sexual and Reproductive Healthcare (FSRH) regularly develops and updates national clinical guidelines. The most recent updated guideline on combined hormonal contraception details the new evidence and suggests recommendations for clinical practice based on this evidence. This guideline will influence clinical and prescribing practice within the speciality of sexual and reproductive health and primary care. This article will critically analyse the impact this updated guideline will have on prescribing practice and will evaluate how the implementation of the recommendations will be influenced by the multidisciplinary team.
BVD Stamp It Out initiative
Authors: Carter Neil
Published: July 2019

In 2018, Defra announced a project focused on controlling bovine viral diarrhoea (BVD) in the national breeding herd in England. The project has become known as Stamp It Out. Run by SAC Consulting alongside Duchy College, Stamp It Out offers funding through the Rural Development Programme for England (RDPE) for cattle keepers in England to draw up plans to control the disease. The headline target for Stamp It Out is to engage 50% of the breeding herd in England in active BVD control planning; this equates to 911 764 breeding cattle.

The overall budget for Stamp It Out is £5.7 million, of which £1.2 million is ring fenced for testing costs. This testing money is split into two available pots: £61.80 per herd to undertake a check test; £440 per SBI number to undertake a persistently infected (PI) animal hunt if check test shows active infection.

With delivery having started in August 2018, as of May 2019, the following successes can be reported: 4187 farmers enrolled, 3483 of which have agreed to join BVDFree England, and their details have been sent across.
A Proof of Labor Theory of Value Based on Marginalist Principle
Authors: Onishi Hiroshi
Published: July 2019

Because anti-Marxist's criticism against Fundamental Marxian Theorem (FMT) is based on an assertion that this proof can be understood as a “natural-resources exploitation,” if we assume, for example, “natural-resources theory of value,” we should prove not only exploitation but also labor theory of value itself. Therefore, this article aims to prove labor theory of value mathematically by focusing on the historically conditional proportionality between labor input and amounts of products which is assumed in labor theory of value. By this proof of the conditional proportionality, we show that marginalist principle does not disturb labor theory of value in capitalism at all. Furthermore, marginalist principle is important to show the labor process as a subjective optimization process which is not by the sun but only by human beings. In this way, we use anti-Marxist's marginal principle to object anti-Marxist criticism against labor theory of value.
No life without family: Film representations of involuntary childlessness, silence and exclusion
Authors: Archetti Cristina
Published: July 2019

Forming a family and having children constitutes an adulthood rite of passage, one of the tacitly assumed requirements of a fulfilled life. What happens, then, when the ‘family dream’ does not materialize? This article addresses the dark sides of the ‘family imperative’ by focusing on representations of involuntary childlessness (i.e. childlessness not by choice) in film. It advances the argument that popular culture, far from being ‘mere entertainment’, plays an important role in wider processes of stigmatization, silencing and, as a result, exclusion of those who do not have a family. The analysis, which is informed by a broader study into the structure of silence surrounding childlessness, presents the findings of a comparative qualitative content analysis that examined the (troubling) representations of involuntary childless individuals in 50 films from Italy, Norway and the United States. It discusses their far-reaching cultural and political implications, making practical suggestions to counter their stigmatizing effects.
The limits of pious families: Religion, family and the state in the women’s pages of Utusan Malaysia (1987–98)
Authors: Randhawa Sonia
Published: July 2019

Between 1987 and 1998, the Malay-language press experienced what appears to be a golden age for media freedom in Malaysia, despite authoritarian legislation. Secure in its support, bolstered by unprecedented economic growth, the government allowed limited criticism and debate. The Malay-Muslim family, however, was seen as increasingly under threat from rapid modernization and the (perceived) influx of women into the workforce. In this milieu, women were expected to shoulder multiple burdens in the home and the workforce. In this context, the women’s pages of the Malay-language daily newspaper Utusan Malaysia policed the makeup of the family, helping women, in particular, make sense of their role as pious wives and mothers and as businesswomen and entrepreneurs. Employing critical discourse analysis of articles published during this period, this article illuminates the workings of power, paying attention to the language used in the articles and the context within which they were written. This article summarizes how the Malay-Muslim family evolved, the shifting role of religion as a marker of the Malay-Muslim family and the strains that domestic policies placed on the Malay-Muslim family. I argue that increasing bureaucratization of Islam increased the burden of responsibilities borne by women, while providing limited redress.
Representations and public discourse of Chinese family cultures across media platforms
Authors: Li Haili
Published: July 2019

Leaving Home (2017), a Chinese reality television show focusing on narrating Chinese family stories with an emphasis on Chinese family cultures, became popular among audiences in 2017. Simultaneously, the show triggered large-scale public attention and heated debate on Weibo, a popular Chinese social media site. This commentary analyses how Chinese family cultures have been represented and framed in Leaving Home, and how the show has influenced and shaped public discourse on social media platforms such as Weibo. A content analysis is used to interpret stories in Leaving Home while textual analysis is deployed to analyse the discussion microblogs on the Weibo topic page of Leaving Home. Three types of Chinese family cultures have been foregrounded through examining the narratives of Leaving Home. The analyses of microblogs have demonstrated that Leaving Home’s constructions of narratives and emphases on certain topics can affect public discourse on Weibo and shape them in specific directions. Leaving Home has inspired people to interpret its stories and embedded Chinese family cultures and values in their own ways by expressing their opinions on Weibo.
Saudi female students’ motivations to study in Australia: A qualitative study
Authors: Binsahl Haifa Mohammad , Chang Shanton , Bosua Rachelle
Published: July 2019

Many transient Saudi Arabian students arrive in Australia annually; more than 5000 new Saudi students enrolled in 2017 to join thousands of tertiary students already in Australia. This article specifically explores the motives of Saudi female international students (SFIS) for leaving Kingdom of Saudi Arabia (KSA) to study in Australia. Data were analysed and evaluated in terms of the ‘push–pull explanation’ of motivation. Salient push elements included the lack of university places and courses for women in KSA, the influence of close relatives (especially male) and Saudi governmental policies. Pull elements included the safety and tolerance of Australia being perceived to be greater than any other western country, Australia’s excellent education system and the relative convenience and ease of Australia’s admission process. The study is significant as it is the first that aims to understand Saudi females’ motivations for studying overseas, especially in Australia.
Self-Healing Concrete Using Bacteria Calcification from Karst Cave Environment
Authors: Nugroho Ananto , Sumarno Agung , Ngeljaratan Luna Nurdianti , Zulfiana Deni , Ratna Ayu Krishanti Ni Putu , Triastutil Triastutil , Widodo Eko
Published: July 2019

Karst regions in Indonesia have the uniqueness of the landscape and biodiversity. The karst is formed by the dissolution of rocks and the precipitation of mineral. In the cave, there are ornaments of stalactite and stalagmite which are formed by the process of mineral precipitation. We have isolated, screened, and identified the soil bacterium from the cave environment (Lysinibacillus macroides). These bacteria are able to precipitate calcium carbonate and can be developed as a self-healing agent concrete. We investigated the proportions and the properties of mixtures concrete containing lightweight aggregate and volcanic ash impregnated with bacteria. A comparison study was made by concrete cylinders subjected to compressive strength tests with and without the bacteria. It found that the strength of concrete with bacteria decreased by less than 10.56% for 28 days of cured specimens. This study showed that the effects of bacteria on the strength of concrete are not considerable. However, these bacteria are effective to repair in the microcrack less than 0.3 mm
Effect of golimumab on endothelial vasomotor function and arterial stiffness in ankylosing spondylitis
Authors: Knyazeva L. A. , Damjanov N. , Knyazeva L. I. , Meshcherina N. S. , Goryainov I. I. , Stepchenko M. A. , Bobyntsev Ya. I. , Rudakov O. S.
Published: July 2019

Objective: to evaluate the effect of golimumab (GLM) on endothelial vasomotor function and arterial stiffness in patients with ankylosing spondylitis (AS).

Subjects and methods. A total of 42 patients with advanced-stage AS, who were older than 18 years and met the 1984 modified New York criteria with a disease duration of ≤5 years, were examined. The investigators visualized carotid arteries to determine local vascular wall stiffness, studied regional arterial stiffness to assess a pulse wave contour analysis, and a reactive hyperemia test before and after 104-week therapy.

Results and discussion. RA patients without cardiovascular comorbidity were found to have signs of subclinical great artery involvement accompanied by endothelial vasoregulatory dysfunction in both the small resistance and large muscular arteries; by increases in common carotid artery (CCA) intima-media thickness (IMT) and stiffness index (SI); by rises in peripheral augmentation index (AIp), SI and reflection index (RI), the intensity of a change in which correlated with disease duration and activity assessed by ASDAS; as well as with the modified Schober test value, cervical rotation, and tragus-to-wall distance. In addition to a decrease in the Ankylosing Spondylitis Disease Activity Score (ASDAS), GML treatment in patients with AS caused a statistically significant increase in the amplitude occlusion index to the control values and a rise in the phase shift between the channels by an average of 2 times (p<0.01) as compared to the baseline values; a decrease in CCA IMT by an average by 20% (p=0.01) and in the local stiffness of the (carotid) vascular bed by 31% (p=0.01). The pulse wave contour analysis after 104-week GLM therapy revealed that AIp, SI and RI decreased by an average of 5 (р<0.001), 1.3 (р<0.01), and 2 (p<0.05) times, respectively, with the remaining statistically significant differences from the control values.

Conclusion. In addition to the effectively reduced inflammatory activity, GLM therapy in patients with AS provides restoration of endothelial function in both the small resistance vessels (an increase in the amplitude occlusion index) and the large muscular arteries (a rise in the phase shift between the channels) and also has a vasoprotective effect on the wall of large elastic vessels (reductions in CCA IMT, SI, AIp, and SI) and small muscular arteries (a decrease in RI).
A New Compound (8,9) -Furanyl-Pterocarpan-3-Ol Used for Standardization of Bengkuang (Pachyrhizus erosus) Extract as Sunscreen and Skin Whitening Agent
Authors: Lukitaningsih Endang , Holzgrabe Ulrike
Published: July 2019

Bengkuang (Pachyrhizus erosus) has been traditionally used as sun screening and skin whitening. The active compounds in bengkuang extract already published included their activities in antioxidant and skin whitening. However, standardization of bengkuang extract has not been studied. This research aims to find out the analysis procedure by High Performance Liquid Chromatography to make standardization bengkuang extract.The first step of this research was collecting bengkuang from Prembun, Central Java, Indonesia in dry season. After cleaning and peeling, bengkuang root was sliced, dried and ground to make powder. Then followed by extraction using Soxhlet in petroleum ether and subsequently in methanol. Methanol extract was evaporated and then partitioned with ethyl acetate-water. Ethyl acetate fraction was evaporated and then separated in open column chromatography using silica gel as stationary phase and a gradient mixture of chloroform-ethyl acetate-methanol as mobile phase. Bio guided fraction method was used for separation and purification to get isolated compounds. The isolated compounds obtained from this fractionation were then elucidated and analyzed their activities.A new compound (8,9-furanyl-pterocarpan-ol) has been selected as a biomarker for extract standardization. The optimum of HPLC condition for standardization consisted of a column (Zorbax SB-C18; i.d. 0.46 cm; 5 μm particle size), mobile phase (gradient elution of MeOH-water) with flow rate of 1 ml/min and detector (UV-detector at 293 nm). The obtained LOD value was 0.51 ± 0.02 µg. The potentials of this compound to absorb UV ray, antioxidant and anti-tyrosinase were 4.018 mAU*S/mml; 2.113±0.001mM (SC50); 7.19±0.11 mM (IC50), respectively.Keywords : bengkuang (Pachyrhizus erosus) extract, (8,9)-furanyl-pterocarpan-3-ol, standardization, sunscreen, skin whitening
IMPLEMENTASI PERATURAN PEMERINTAH NOMOR 46 TAHUN 2011 TENTANG PENILAIAN PRESTASI KERJA PEGAWAI NEGERI SIPIL DI KABUPATEN SERUYAN PROVINSI KALIMANTAN TENGAH
Authors: Addeli Addeli , Warsono Hardi
Published: July 2019

Assessment or evaluation on the performance of an employee is a very importantpart to know the quality of work and behavior in carrying out the duties of service to thecommunity. Therefore it is appropriate if the Government issued Government RegulationNumber 46 Year 2011 on Employee Performance Appraisal which in it regulates theassessment of employee performance based on Employee Work Objectives (SKP) andEmployee Work Behavior. The irony is that Seruyan Regency has implemented thisGovernment Regulation from 2014 until now, but it is still far from what is expected byGovernment Regulation Number 46 Year 2011 on Job Performance Appraisal of thisEmployee. This phenomenon underlying for qualitative research using theImplementation Model of Government Regulation No. 46 of 2011 on EmployeePerformance Appraisal in Seruyan Regency using George C. Edward III theory whichsees the implementation process through Communication, Resources, Disposition andOrganizational Structure as well as policy content. The result of the research shows thatthere are still many employees who have not understood and acknowledged about theperformance appraisal and the absence of supervision made causing the implementationof government regulation is not running according to the regulation. Factors that hamperthe implementation of this policy include the number of personnel Personnel Agency andHuman Resources Development (BKPSDM) Seruyan District is very minimal in theprocess of disseminating and training this policy and the absence of Standard Operating(SOP) in the implementation of the field that causes the implementers and recipients tobe not focus.
Strategi Partai Perindo jelang pemilu 2019
Authors: Susanto Andry
Published: July 2019

Penelitian ini bertujuan untuk mengetahui strategi Partai Perindo jelang pemilu 2019. Strategi tersebut dilihat berdasarkan strategi pendekatan yang dilakukan di internal dan eksternal partai. Penelitian ini menggunakan metode studi kasus yang memfasilitasi eksplorasi dari fenomena yang terjadi melalui proses wawancara, dokumentasi, dan kajian literasi. Penelitian menggunakan konsep teori Huntington terkait pelembagaan partai politik, yang dikembangkan kembali oleh Vicky Randall dan Lars Svasand dengan menjelaskan aspek eksternal - internal dan struktural - kultural. Kesimpulan utama, Partai Perindo menggunakan strategi yang sesuai dengan derajat kesisteman (systemness), derajat identitas nilai (value infusion), derajat otonomi (decisional autonomy), dan citra publik (reification). Pemilu 2019 menjadi pertaruhan bagi Partai Perindo, figur ketua umum Hary Tanoesoedibjo (HT) menjadi penentu, karena sepakterjangnya otomatis berimbas pada keberlangsungan partai.
Dari identitas ke ideologi: Penguatan arah kebijakan programatik partai politik
Authors: Alfirdaus Laila Kholid
Published: July 2019

Sebagaimana disepakati berbagai pihak, persoalan partai politik di Indonesia saat ini secara mendasar terletak pada karakter pragmatisme yang makin menguat. Partai dianggap kehilangan ruh idologisnya sehingga menyebabkan arah kebijakan yang diadvokasi partai menjadi miskin identitas. Publik dan masyarakat pemilih kesulitan membedakan orientasi kebijakan partai karena partai seringkali merespon isu-isu nasional sehari-hari hanya berdasarkan pertama, kepentingan elektoral, dimana partai menolak atau mendukung sebuah kebijakan hanya berdasarkan hitung-hitungan pemeliharaan suara di pemilu. Partai oposisi akan selalu menolak ide partai berkuasa, dan sebaliknya, partai berkuasa akan selalu menentang pendapat partai oposisi. Faktornya penentunya hanya terkait pada apakah partai sedang berkuasa atau menjadi oposisi, bukan pada ideologi sebagai identitas partai itu sendiri. Hasilnya, partai yang sama dapat memiliki pandangan yang berbeda atas isu yang sama di periode politik yang berbeda, tergantung apakah partai tersebut sedang menjadi partai berkuasa atau partai oposisi. Kedua, arah kebijakan partai juga seringkali lebih terkait dengan kepentingan sekelompok kecil elit didalamnya. Arah kebijakan partai dalam hal ini hanya digunakan untuk melayani kepentingan segelintir orang yang mengendalikan partai, alih-alih kepentingan publik secara luas. Hasilnya, partai nir konsistensi, menyebabkan kesulitan identifikasi arah kebijakan partai ke depan. Pilihan politik pun kemudian hanya diputuskan berdasarkan pertimbangan jangka pendek, menyebabkan lemahnya afiliasi dan identifikasi politik pemilih. Dalam hal ini, kita jelas sedang menghadapi resiko pelembagaan demokrasi dan kepartaian yang lemah. Memikirkan perbaikan landasan ideologis kepartaian dengan demikian menjadi sangat krusial. Ideology shifting di tubuh partai menjadi kebutuhan yang tidak lagi terelakkan.