bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Generation of Arachidonic Acid Analogues as Potential Neurological Agent Targeting Cytosolic Phospholipase A2
Authors: Ng Cheng Yang , Kannan Srinivasaraghavan , Chen Yong Jun , Tan Francis Chee Kuan , Ong Wee Yong , Go Mei Lin , Verma Chandra S. , Low Chian-Ming , Lam Yulin
Published: October 2017

Cytosolic phospholipase A2 (cPLA2) is an enzyme that releases arachidonic acid (AA) for the synthesis of eicosanoids and lysophospholipids which play critical roles in the initiation and modulation of oxidative stress and neuroinflammation. In the central nervous system, cPLA2 activation is implicated in the pathogenesis of various neurodegenerative diseases that involves neuroinflammation, thus making it an important pharmacological target. In this paper, a new class of arachidonic acid (AA) analogues was synthesized and evaluated for their ability to inhibit cPLA2. Several compounds were found to inhibit cPLA2 more strongly than arachidonyl trifluoromethyl ketone (AACOCF3), an inhibitor that is commonly used in the study of cPLA2-related neurodegenerative diseases. Subsequent experiments concluded that one of the inhibitors was found to be cPLA2-selective, non-cytotoxic, cell and brain penetrant and capable of reducing reactive oxygen species (ROS) and nitric oxide (NO) production in stimulated microglial cells. Computational studies were employed to understand how the compound interacts with cPLA2.
Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction
Authors: Bezerra Otávio C. , França Cristiane Miranda , Rocha Juraci Aparecida , Neves Gizele A. , Souza Pamella Ramona M. , Teixeira Gomes Mariana , Malfitano Christiane , Loleiro Tatiane C. Alba , Dourado Paulo Magno , Llesuy Susana , de Angelis Katia , Irigoyen Maria Claudia C. , Ulloa Luis , Consolim-Colombo Fernanda M.
Published: October 2017

We previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we evaluated the anti-inflammatory effects of PY during the proliferative phase of cardiac repair by analyzing the infiltration of macrophages, Treg lymphocytes, oxidative stress and inflammatory cytokines. Wistar rats underwent control sham surgery or ligation of the left coronary artery and were randomly allocated to remain untreated (untreated infarcted group, I) or to receive PY (30 mg·kg(−1)·day(−1)) in the supplied water (infarcted treated group, I + PY). Blood pressure and heart rate variability were registered at day 5 post-MI. The animals were euthanized 7 days after thoracotomy, when the hearts were removed and processed for immunohistochemistry (CD68, CD206, FOXP3), cytokines (IL-1β, IL-6, IL-10, TNF-α) and oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, lipidic and protein peroxidation). PY treatment increased parasympathetic modulation, M2 macrophages and the anti-oxidant enzyme activity but reduced protein oxidation (carbonyls) and the concentration of IL-1β, IL-6, TNF-α and IL-10. Cholinergic stimulation induces parasympathetic neuro-immune modulation and anti-inflammatory cell enrollment as well as prevents oxidative stress and cytokine production after MI.
Helicobacter pylori γ-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence
Authors: Wüstner Stefanie , Anderl Florian , Wanisch Andreas , Sachs Corinna , Steiger Katja , Nerlich Andreas , Vieth Michael , Mejías-Luque Raquel , Gerhard Markus
Published: October 2017

Helicobacter pylori γ-glutamyl transferase (gGT) is a key bacterial virulence factor that is not only important for bacterial gastric colonization but also related to the development of gastric pathology. Despite accumulating evidence for pathogenic and immunologic functions of H. pylori gGT, it is still unclear how it supports gastric colonization and how its specific effects on the host’s innate and adaptive immune responses contribute to colonization and pathology. We have compared mice showing similar bacterial load after infection with gGT-proficient or gGT-deficient H. pylori to analyse the specific role of the enzyme during infection. Our data indicate that H. pylori gGT supports initial colonization. Nevertheless, bacteria lacking gGT can still colonize and persist. We observed that the presence of gGT during infection favoured a proinflammatory innate and adaptive immune response. Notably, H. pylori gGT activity was linked to increased levels of IFNγ, which were attributed to a differential recruitment of CD8+ T cells to the stomach. Our data support an essential role for H. pylori gGT in gastric colonization and further suggest that gGT favours infiltration of CD8+ cells to the gastric mucosa, which might play an important and yet overlooked role in the pathogenesis of H. pylori.
Molecular spectrum of excision repair cross-complementation group 8 gene defects in Chinese patients with Cockayne syndrome type A
Authors: Wang Xiaozhu , Huang Yu , Yan Ming , Li Jiuwei , Ding Changhong , Jin Hong , Fang Fang , Yang Yanling , Wu Baiyan , Chen Dafang
Published: October 2017

There are two genetics complementary groups Cockayne syndrome type A and B (CS-A and CS-B OMIM 216400, 133540), which is a rare autosomal recessive segmental progeroid syndrome. Homozygous or compound heterozygous mutations in the excision repair cross-complementation group 8 gene (ERCC8) result in CS-A, and mutations in ERCC6 result in CS-B. Homozygous ERCC6/ERCC8 mutations also result in UV-sensitive syndrome. In this study, twenty-one Han Chinese patients with CS were investigated to identify mutations in ERCC8/ERCC6, of which thirteen cases with CS-A were identified with the mutations of ERCC8. There are five types mutations of ERCC8 in our study, such as exon 4 rearrangement, c.394_398delTTACA, c.299insA, c.843 + 2 T > C, and c.2 T > A. An estimated frequency of exon 4 rearrangement accounts for 69.23% and c.394_398delTTACA accounts for 11.53% in our cohort. Haplotype analysis revealed that the exon 4 rearrangement and c.394_398delTTACA mutations originated from a common founder in the Chinese population respectively. With the identification of three novel ERCC8 mutations, this study expanded the molecular spectrum of known ERCC8 defects, and furthermore, suggests that the exon 4 rearrangement and c.394_398delTTACA mutations may be a common underlying cause of CS-A in the Chinese population, which is different from that in other populations.
MultiFLEXX - The new multi-analyzer at the cold triple-axis spectrometer FLEXX
Authors: Groitl Felix , Toft-Petersen Rasmus , Quintero-Castro Diana Lucia , Meng Siqin , Lu Zhilun , Huesges Zita , Le Manh Duc , Alimov Svyatoslav , Wilpert Thomas , Kiefer Klaus , Gerischer Sebastian , Bertin Alexandre , Habicht Klaus
Published: October 2017

The first experimental characterization of a multiple energy analysis wide angle backend for a cold triple-axis spectrometer is reported. The multi-analyzer module MultiFLEXX employs 155 detection channels which simultaneously probe an extensive range in wavevector and energy transfer. Successful mapping of magnetic excitations in MnF2and Ho demonstrate order of magnitude gains in data collection efficiency using this novel type backend. MultiFLEXX is competitive to standard triple-axis spectroscopy in terms of energy resolution and signal-to-noise ratio. A minority of the detector channels is affected by spurious signals inherent to this multiplexing concept. The characteristic signature of these spurious signals easily allows for their discrimination. The instrument concept focuses on detection efficiency in the horizontal scattering plane which makes it an ideal technique for fast mapping and parametric studies including extreme sample environment.
Analyzing homoeolog expression provides insights into the rediploidization event in gynogenetic hybrids of Carassius auratus red var. × Cyprinus carpio
Authors: Ren Li , Cui Jialin , Wang Jing , Tan Hui , Li Wuhui , Tang Chenchen , Qin Qinbo , Liu Shaojun
Published: October 2017

Rediploidization is considered to be a part of the evolutionary history of allotetraploids, and resulted in the emergence of novel epigenetic regulatory activities. To study the changing patterns of gene expression following the reduction of a genome by 50%, we used RNA-seq and quantitative real-time PCR (qPCR) to investigate total gene expression and homoeolog expression in three hybrids of a C. auratus red var. (2n = 100, ♀) (R) and C. carpio (2n = 100, ♂) (C) (i.e., F1, F18, and G4) and their original parents. A comparison of homoeolog expression between G4 and F18 identified 7 genes (0.22%) that exhibited novel R/C homoeolog expression patterns in G4, while 4 genes (0.12%) were affected by R/C homoeolog silencing. We determined the direction and extent of the homoeolog expression bias (HEB). The C-HEB genes (i.e., nrp1a and igf1) and R-HEB genes (i.e., fgf23 and esm1) provided insights into the effects of the dominance of one parental homoeolog expression on growth regulation. This dominance may contribute to the rapid growth of G4 fish. Our findings may be relevant for clarifying the relationship between growth heterosis and differences in homoeolog expression patterns.
Significance of CCL2, CCL5 and CCR2 polymorphisms for adverse prognosis of Japanese encephalitis from an endemic population of India
Authors: Chowdhury Purvita , Khan Siraj Ahmed
Published: October 2017

Japanese encephalitis (JE) is a major contributor for viral encephalitis in Asia. Vaccination programme has limited success for largely populated JE endemic countries like India and disease exposure is unavoidable. Involvement of chemokines and its co-receptors for adverse prognosis of JE have been documented both in vitro and in vivo. Identification of the genetic predisposing factor for JE infection in humans is crucial but not yet established. Therefore, we investigated the association of single nucleotide polymorphisms (SNPs) in chemokines (CCL2 and CCL5) and its co-receptors (CCR2 and CCR5) with their protein level for JE. The study enrolled 87 symptomatic JE cases (mild: severe = 24:63) and 94 asymptomatic controls. Our study demonstrated that CCL2 (rs1024611G), CCL5 (rs2280788G) and CCR2 (rs1799864A) significantly associated with JE (Odds ratio = 1.63, 2.95 and 2.62, respectively and P = 0.045, P = 0.05 and P = 0.0006, respectively). The study revealed that rs1024611G allele was associated with elevated level of CCL2. CCL5 elevation associated with JE mortality having a Cox proportional hazard of 1.004 (P = 0.033). In conclusion, SNPs of chemokine viz. CCL2 (rs1024611G) and its receptor CCR2 (rs1799864A) significantly associated with JE which may serve as possible genetic predisposing factor and CCL5 protein level may act as marker for disease survival.
The rice TRIANGULAR HULL1 protein acts as a transcriptional repressor in regulating lateral development of spikelet
Authors: Peng Peng , Liu Lihua , Fang Jingjing , Zhao Jinfeng , Yuan Shoujiang , Li Xueyong
Published: October 2017

As a basic unit of rice inflorescence, spikelet has profound influence on grain size, weight and yield. The molecular mechanism underlying spikelet development has not been fully elucidated. Here, we identified four allelic rice mutants, s2-89, xd151, xd281 and xd425, which exhibited reduced width of spikelet, especially in the apical region. Map-based cloning revealed that all these mutants had missense mutation in the TRIANGULAR HULL1 (TH1) gene, encoding an ALOG family protein. TH1 has been shown to regulate the lateral development of spikelet, but its mode of action remains unclear. Microscopic analysis revealed that the reduction in spikelet width was caused by decreased cell size rather than cell division. The TH1 protein was shown to localize in the nucleus and possess transcriptional repression activity. TH1 could form a homodimer and point mutation in the s2-89, xd281 and xd425 mutant inhibited homodimerization. The transcriptional repression activity of TH1 was partially relieved by the His129Tyr substitution in the s2-89 mutant. Fusion of an exogenous EAR transcription suppression domain to the mutant protein TH1s2-89 could largely complemented the narrow spikelet phenotype. These results indicate that TH1 functions as a transcription repressor and regulates cell expansion during the lateral development of spikelet.
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
Authors: Vicente Miranda Hugo , Cássio Rafaela , Correia-Guedes Leonor , Gomes Marcos António , Chegão Ana , Miranda Elisa , Soares Tiago , Coelho Miguel , Rosa Mário Miguel , Ferreira Joaquim J. , Outeiro Tiago Fleming
Published: October 2017

Parkinson’s disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practice. Posttranslational modifications (PTMs) in aSyn have been identified and implicated on its pathobiology. Since aSyn is abundant in blood erythrocytes, we aimed to evaluate whether PTMs of aSyn in the blood might hold value as a biomarker for PD. We examined 58 patients with PD and 30 healthy age-matched individuals. We found that the levels of Y125 phosphorylated, Y39 nitrated, and glycated aSyn were increased in PD, while those of SUMO were reduced. A combinatory analysis of the levels of these PTMs resulted in an increased sensitivity, with an area under curve (AUC) of 0.843 for PD versus healthy controls, and correlated with disease severity and duration. We conclude that the levels of these selected PTMs hold strong potential as biochemical markers for PD. Ultimately, our findings might facilitate the monitoring of disease progression in clinical trials, opening the possibility for developing more effective therapies against PD.
Antibiotics ameliorate lupus-like symptoms in mice
Authors: Mu Qinghui , Tavella Vincent J. , Kirby Jay L. , Cecere Thomas E. , Chung Matthias , Lee Jiyoung , Li Song , Ahmed S. Ansar , Eden Kristin , Allen Irving Coy , Reilly Christopher M. , Luo Xin M.
Published: October 2017

Gut microbiota and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of systemic lupus erythematosus (SLE) is unclear. Here we report that oral antibiotics given during active disease removed harmful bacteria from the gut microbiota and attenuated SLE-like disease in lupus-prone mice. Using MRL/lpr mice, we showed that antibiotics given after disease onset ameliorated systemic autoimmunity and kidney histopathology. They decreased IL-17-producing cells and increased the level of circulating IL-10. In addition, antibiotics removedLachnospiraceaeand increased the relative abundance ofLactobacillusspp., two groups of bacteria previously shown to be associated with deteriorated or improved symptoms in MRL/lpr mice, respectively. Moreover, we showed that the attenuated disease phenotype could be recapitulated with a single antibiotic vancomycin, which reshaped the gut microbiota and changed microbial functional pathways in a time-dependent manner. Furthermore, vancomycin treatment increased the barrier function of the intestinal epithelium, thus preventing the translocation of lipopolysaccharide, a cell wall component of Gram-negativeProteobacteriaand known inducer of lupus in mice, into the circulation. These results suggest that mixed antibiotics or a single antibiotic vancomycin ameliorate SLE-like disease in MRL/lpr mice by changing the composition of gut microbiota.
Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs
Authors: Han Shengli , Lv Yanni , Kong Liyun , Che Delu , Liu Rui , Fu Jia , Cao Jiao , Wang Jue , Wang Cheng , He Huaizhen , Zhang Tao , Dong Xinzhong , He Langchong
Published: October 2017

Anaphylactoid reactions are common clinical acute adverse drug reactions that can exacerbate a patient’s condition and produce effects that may become life-threatening. Therefore, it is important to establish a novel method to evaluate drugs for anaphylactoid reactions. In this study, we developed a sensitive and rapid method to detect histamine release from LAD2 cells using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and constructed a relative release index based on various release curve parameters, including allergen release time and sudden change rate, to evaluate the potential and strength of allergen-induced anaphylactoid reactions. This LAD2 release model was used to evaluate anaphylactoid reactions induced by ciprofloxacin, norfloxacin, lomefloxacin, moxifloxacin, and baicalin. The results positively correlated with those obtained with an Evans blue ear test and negatively correlated with the Ca2+ influx EC50. In summary, the current study established a novel in vitro method to analyze the properties of histamine release from LAD2 cells and characterize the sensitization and strength of sensitization of drugs or components that may induce anaphylactoid reactions.
Investigation of foaming causes in three mesophilic food waste digesters: reactor performance and microbial analysis
Authors: He Qin , Li Lei , Zhao Xiaofei , Qu Li , Wu Di , Peng Xuya
Published: October 2017

Foaming negatively affects anaerobic digestion of food waste (FW). To identify the causes of foaming, reactor performance and microbial community dynamics were investigated in three mesophilic digesters treating FW. The digesters were operated under different modes, and foaming was induced with several methods. Proliferation of specific bacteria and accumulation of surface active materials may be the main causes of foaming. Volatile fatty acids (VFAs) and total ammonia nitrogen (TAN) accumulated in these reactors before foaming, which may have contributed to foam formation by decreasing the surface tension of sludge and increasing foam stability. The relative abundance of acid-producing bacteria (Petrimonas, Fastidiosipila, etc.) and ammonia producers (Proteiniphilum, Gelria, Aminobacterium, etc.) significantly increased after foaming, which explained the rapid accumulation of VFAs and NH4+ after foaming. In addition, the proportions of microbial genera known to contribute to foam formation and stabilization significantly increased in foaming samples, including bacteria containing mycolic acid in cell walls (Actinomyces, Corynebacterium, etc.) and those capable of producing biosurfactants (Corynebacterium, Lactobacillus, 060F05-B-SD-P93, etc.). These findings improve the understanding of foaming mechanisms in FW digesters and provide a theoretical basis for further research on effective suppression and early warning of foaming.
Long-stem shaped multifunctional molecular beacon for highly sensitive nucleic acids determination via intramolecular and intermolecular interactions based strand displacement amplification
Authors: Xu Jianguo , Zheng Tingting , Le Jingqing , Jia Lee
Published: October 2017

LS-MMB based intra-SDA and inter-SDA for amplified gene signaling.
Reversion of gold nanoparticle aggregates for the detection of Cu2+and its application in immunoassays
Authors: Chang Chia-Chen , Lee Chung-Han , Wu Tzu-Heng , Chen Chie-Pein , Chen Chen-Yu , Lin Chii-Wann
Published: October 2017

The aggregation of cysteamine-modified AuNPs (CA-AuNPs) can easily change into the dispersion of CA-AuNPs in a basic medium, and redispersed CA-AuNPs can be used for the detection of Cu2+.
Rapid derivatization and extraction of paraben preservatives by fast syringe-assisted liquid–liquid microextraction and their determination in cosmetic and aqueous sample solutions by gas chromatography
Authors: Rajabi Maryam , Sarhadi Alireza , Bazregar Mohammad , Asghari Alireza , Mirparizi Ehsan
Published: October 2017

In this work, a very rapid method is developed for the simultaneous derivatization and extraction of some parabens in aqueous sample solutions.
A dual-mode nanosensor based on the inner filter effect of gold nanoparticles on the fluorescence of CdS quantum dots for sensitive detection of arginine
Authors: Khezri Somayeh , Bahram Morteza , Samadi Naser
Published: October 2017

Fluorescent detection of arginine based on the inner filter effect of AuNPs on l-Cys-capped CdS QDs.
The combination of NIR spectroscopy and HPLC chromatography for differentiating lotus seed cultivars and quantitative prediction of four main constituents in lotus with the aid of chemometrics
Authors: Guo Ying , Ding Xiaoxiao , Ni Yongnian
Published: October 2017

With the aid of chemometrics, NIR and HPLC were used to discriminate different lotus seed cultivars, and simultaneously quantify four important components in lotus seeds.
A novel polydentate Schiff-base derivative developed for multi-wavelength colorimetric differentiation of trace Fe2+ from Fe3+
Authors: Yan Zhengquan , Zhu Yanjie , Xu Jie , Wang Cong , Zheng Yuyu , Li Pengyue , Hu Lei , You Jinmao
Published: October 2017

A novel Schiff-base polydentate derivative (NNAP) was developed as a practical probe for multi-wavelength colorimetric differentiation of trace Fe2+ from Fe3+.
A highly selective and sensitive fluorescence sensor for the detection of apigenin based on nitrogen doped carbon dots and its application in cell imaging
Authors: Li Jing , Song Jinping , Liang Xiaomin , Ma Qi , Shen Lazhen , Guo Yong , Feng Feng
Published: October 2017

This work proposes a simple fluorescent sensor and method for the determination of apigenin in celery based on N-doped carbon dots.
Defined pH-sensitive nanogels as gene delivery platform for siRNA mediated in vitro gene silencing
Authors: Dimde Mathias , Neumann Falko , Reisbeck Felix , Ehrmann Svenja , Cuellar-Camacho Jose Luis , Steinhilber Dirk , Ma Nan , Haag Rainer
Published: October 2017

An advanced cationic carrier system which combines high transfection efficiency with low cytotoxicity and a control over the release of the encapsulated genetic material by the reduction of the multivalent architecture upon pH triggered degradation was developed.
Surface potential and morphology mapping to investigate analyte adsorption effects on surface enhanced Raman scattering (SERS)
Authors: Chatterjee Abhijit , Gale David J. G. , Grebennikov Dmytro , Whelan Liam D. , Merschrod S. Erika F.
Published: October 2017

Predicting the effect of analyte adsorption in SERS using surface potential mapping by Kelvin probe force microscopy.
Trapping of superoxido cobalt and peroxido dicobalt species formed reversibly from CoII and O2
Authors: Corona Teresa , Padamati Sandeep K. , Acuña-Parés Ferran , Duboc Carole , Browne Wesley R. , Company Anna
Published: October 2017

Superoxido cobalt(iii) and peroxido dicobalt(iii) species are formed in the temperature dependent reversible reaction of a common cobalt(ii) precursor with O2.
Enantioselective syntheses of atropisomers featuring a five-membered ring
Authors: Bonne Damien , Rodriguez Jean
Published: October 2017

If six-membered ring biaryl or heterobiaryl atropisomers are the most common ones, the focus of this feature article will be put on the enantioselective approaches towards five-membered ring containing atropisomers displaying either a stereogenic C–N- or C–C bond.
Bcl-XL-binding helical peptides possessingd-Ala residues at their C-termini with the advantage of long-lasting intracellular stabilities
Authors: Nogami Kagayaki , Tokumaru Hiroshi , Isokawa Gouchi , Oyoshi Takanori , Fujimoto Kazuhisa , Inouye Masahiko
Published: October 2017

We attachedd-Ala residues to cross-linked helical peptides based on the pro-apoptotic protein Bad at their C-termini.
A Cu3P–CoP hybrid nanowire array: a superior electrocatalyst for acidic hydrogen evolution reactions
Authors: Du Huitong , Zhang Xiaoping , Tan Qingqing , Kong Rongmei , Qu Fengli
Published: October 2017

Cu3P–CoP/CC exhibits superior catalytic HER performance, needing an overpotential of 59 mV at 10 mA cm−2in acidic media.
Effects of phosphate on biotite dissolution and secondary precipitation under conditions relevant to engineered subsurface processes
Authors: Zhang Lijie , Kim Doyoon , Kim Yongman , Wan Jiamin , Jun Young-Shin
Published: October 2017

Phosphate-induced brine–mica interactions affect both the caprock integrity and the fate and transport of reactive fluids at deep subsurface sites.
Fluoride substitution in LiBH4; destabilization and decomposition
Authors: Richter Bo , Ravnsbæk Dorthe B. , Sharma Manish , Spyratou Alexandra , Hagemann Hans , Jensen Torben R.
Published: October 2017

Illumination of the decomposition mechanism for fluoride substituted LiBH4 by thermal analysis, infrared spectroscopy and powder X-ray diffraction.
Curly arrows, electron flow, and reaction mechanisms from the perspective of the bonding evolution theory
Authors: Andrés Juan , González-Navarrete Patricio , Safont Vicent Sixte , Silvi Bernard
Published: October 2017

The BET study provides the nature of the reaction mechanism by finding the electronic flow processes along the reaction progress.
Long-range magnetic order in the porous metal–organic framework Ni(pyrazine)[Pt(CN)4]
Authors: Rodríguez-Velamazán J. Alberto , Roubeau Olivier , Poloni Roberta , Lhotel Elsa , Palacios Elías , González Miguel A. , Real José A.
Published: October 2017

Long-range magnetic ordering is demonstrated in {Ni(pyrazine)[Pt(CN)4]}, which opens new perspectives for multifunctionality in this class of porous coordination compounds.
W-doped MoS2 nanosheets as a highly-efficient catalyst for hydrogen peroxide electroreduction in alkaline media
Authors: Xue Yudong , Cai Weiquan , Zheng Shili , Yan Wenyi , Hu Jiugang , Sun Zhi , Zhang Yi , Jin Wei
Published: October 2017

Novel W-doped MoS2 electrocatalysts have been successfully fabricated through a facile one-pot solvothermal method and employed for the hydrogen peroxide reduction reaction (HPRR) in emerging alkaline H2O2-based fuel cells.
Design and synthesis of Co–N–C porous catalyst derived from metal organic complexes for highly effective ORR
Authors: Liu Heng , Wang Min-Qiang , Chen Zhao-Yang , Chen Hao , Xu Mao-Wen , Bao Shu-Juan
Published: October 2017

In this work, a novel and slack rose-like metal organic precursor was designed and used for the preparation Co and N co-doping carbon materials. As the ORR catalysts, they delivered comparable electrochemical performance with Pt/C.
Synthesis of 13-vertex dimetallacarboranes by electrophilic insertion into 12-vertex ruthenacarboranes
Authors: Perekalin Dmitry S. , Lyssenko Konstantin A. , Kudinov Alexander R. , Corsini Maddalena , Fabrizi de Biani Fabrizia
Published: October 2017

An uncommon method for the synthesis of 13-vertex dimetallacarboranes is presented along with a discussion of the violation of Wade's rules.
The synthesis and reactivity of 16-electron half-sandwich iridium complexes bearing a carboranylthioamide ligand
Authors: Cui Peng-Fei , Lin Yue-Jian , Jin Guo-Xin
Published: October 2017

The 16-electron complex2has been synthesized. It can react with different donor ligands and undergoes M–S bond insertion reactions with DMAD. Complex2is shown to react with [Cp*Ir] unit to form a M–M-bound binuclear complex. Interestingly, the metal–metal bond could be broken by HCl to produce the selective B(6)–H activation species.
The presence of food-derived collagen peptides in human body-structure and biological activity
Authors: Sato Kenji
Published: October 2017

While it was difficult to detect food-derived peptide in blood (A), recent advances enables identify them (B) and examine their biological activities.
Pepsin egg white hydrolysate ameliorates metabolic syndrome in high-fat/high-dextrose fed rats
Authors: Moreno-Fernández S. , Garcés-Rimón M. , González C. , Uranga J. A. , López-Miranda V. , Vera G. , Miguel M.
Published: October 2017

The aim of this study was to examine the effect of a pepsin egg white hydrolysate (EWH) on metabolic complications using a high-fat/high-dextrose diet-induced Metabolic Syndrome (MetS) experimental model.
Towards sustainable manufacture of epichlorohydrin from glycerol using hydrotalcite-derived basic oxides
Authors: Lari Giacomo M. , Pastore Giorgio , Mondelli Cecilia , Pérez-Ramírez Javier
Published: October 2017

Regenerable hydrotalcite-derived Mg–Al oxide is an effective heterogeneous base to avoid waste formation and enable halogen recycling in the glycerol-to-epichlorohydrin process.
A microfluidic microinjector for toxicological and developmental studies in Drosophila embryos
Authors: Ghaemi Reza , Arefi Pouya , Stosic Ana , Acker Meryl , Raza Qanber , Roger Jacobs J. , Selvaganapathy Ponnambalam Ravi
Published: October 2017

A microfluidic microinjector to deliver reagents and biomolecules to precise locations inside aDrosophilaembryo.
A simple culture system for long-term imaging of individual C. elegans
Authors: Pittman William E. , Sinha Drew B. , Zhang William B. , Kinser Holly E. , Pincus Zachary
Published: October 2017

A novel PDMS-hydrogel binding chemistry traps many individualC. eleganson a solid surface for lifelong culture and imaging.
Synthesis of poly(styrene-b-4-(tert-butyldimethylsiloxy)styrene) block copolymers and characterization of their self-assembled patterns
Authors: Hur Yoon Hyung , Song Seung Won , Mays Jimmy , Kim YongJoo , Kang Beom-Goo , Jung Yeon Sik
Published: October 2017

Self-assembly behavior of poly(styrene-b-4-(tert-butyldimethylsiloxy)styrene) (PS-b-P4BDSS) block copolymer and the effect of polydispersity on self-assembled pattern quality.
Theoretical guidance for experimental research of the dicyandiamide and methacrylic acid molecular imprinted polymer
Authors: Liu Junbo , Wang Yan , Tang Shanshan , Gao Qian , Jin Ruifa
Published: October 2017

The DCD-MIPs displayed good adsorption properties to DCD, which can be applied to the separation and detection of DCD.
Phenylboronic acid-functionalized core–shell magnetic composite nanoparticles as a novel protocol for selective enrichment of fructose from a fructose–glucose aqueous solution
Authors: Gu Lei , Wang Yun , Han Juan , Wang Lei , Tang Xu , Li Cheng , Ni Liang
Published: October 2017

We developed an efficient and mild method for the preparation of boronic acid-functionalized magnetic nanoparticles (MNPs), and the selective separation of fructose from a sample solution was demonstrated for the first time.
Tunable compositions of Pd100−xCux catalysts towards the electrooxidation of ethanol and ethylene glycol
Authors: Babu Sreejith P. , Elumalai Perumal
Published: October 2017

Tunable compositions of Pd100−xCux towards the electrooxidation of ethanol and ethylene glycol have been examined. The Pd70Cu30 exhibited the highest activity and stability.
Roles of coating carbon, conductive additive and binders in lithium vanadium phosphate/reduced graphene oxide composite cathodes
Authors: Huo Hua , Lin Zeyu , Guo Shu , Shao Jinyu , Zhang Guangming , Wang Qun
Published: October 2017

Supreme high rate cycling performance can be achieved by optimizing the composition of LVP electrode.
Monolithic Cu/C hybrid beads with well-developed porosity for the reduction of 4-nitrophenol to 4-aminophenol
Authors: Xiao Zuo-Yi , Zhai Shang-Ru , Ma Xiu-Ping , Zhao Zhen-Yu , Wang Xin , Bai Hao , An Qing-Da
Published: October 2017

Cu/C hybrid beads with well-developed porosity, offering potential advantages of low cost, an environmentally friendly fabrication process, easy processing and durable activity, were successfully fabricated.
Graphene oxide based planar heterojunction perovskite solar cell under ambient condition
Authors: Ahmad Khursheed , Mobin Shaikh M.
Published: October 2017

Herein, we developed a highly stable planar heterojunction perovskite solar cell (PSC) with a novel architecture (ITO/GO/PEDOT:PSS/MAPbI3/PCBM/carbon tape).
Directional synthesis of α-AgFe(MoO4)2 from {Mo72Fe30}-type Keplerate
Authors: Tandekar Kesar , Supriya Sabbani
Published: October 2017

Compound [Mo72Fe30O252(CH3COO)12{Mo2O7(H2O)}2{H2Mo2O8(H2O)}(H2O)91]·150 H2O (1), on treatment with AgNO3 in an aqueous solution under refluxing condition results in the selective formation of α-AgFe(MoO4)2.
Synthesis of thermo- and photo-responsive polysiloxanes with tunable phase separationviaaza-Michael addition
Authors: Feng Kai , Li Shusheng , Feng Linglong , Feng Shengyu
Published: October 2017

Two kinds of thermo- and photo-dual-responsive polysiloxanes were synthesized through a facile, effective, and catalyst-free aza-Michael addition.
Synthesis and gas sorption behaviour of ZIF-90 with large pore volume
Authors: Liguori Paola F. , Russo Beatrice , Melicchio Alessandro , Golemme Giovanni
Published: October 2017

Stoichiometric triethylamine in methanol deprotonates the imidazole and yields 98% sub-micrometric ZIF-90 with no residual solvent in the pores.
Challenging metastatic breast cancer with the natural defensinPvD1
Authors: Figueira Tiago N. , Oliveira Filipa D. , Almeida Inês , Mello Érica O. , Gomes Valdirene M. , Castanho Miguel A. R. B. , Gaspar Diana
Published: October 2017

PvD1 hampers brain metastasis development by manipulating the biomechanical properties of tumor cells and preventing their adhesion to the blood–brain-barrier.
Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading
Authors: Zhang Fuwu , Khan Sarosh , Li Richen , Smolen Justin A. , Zhang Shiyi , Zhu Guizhi , Su Lu , Jahnke Ashlee A. , Elsabahy Mahmoud , Chen Xiaoyuan , Wooley Karen L.
Published: October 2017

Polyphosphoester-based nanoparticles are capable of loading paclitaxel chemically and physically, achieving ultrahigh equivalent paclitaxel aqueous concentrations.
Unraveling current hysteresis effects in regular-type C60-CH3NH3PbI3heterojunction solar cells
Authors: Chen Lung-Chien , Lin Yu-Shiang , Tang Po-Wen , Tai Chao-Yi , Tseng Zong-Liang , Lin Ja-Hon , Chen Sheng-Hui , Kuo Hao-Chung
Published: October 2017

Comprehensive studies were carried out to understand the origin of the current hysteresis effects in highly efficient C60-CH3NH3PbI3(MAPbI3) heterojunction solar cells, using AFM, transmittance spectra, PL spectra, XRD patterns, and a femtosecond time-resolved pump–probe technique.
Copper catalyzed oxidative homocoupling of terminal alkynes to 1,3-diynes: a Cu3(BTC)2 MOF as an efficient and ligand free catalyst for Glaser–Hay coupling
Authors: Devarajan Nainamalai , Karthik Murugan , Suresh Palaniswamy
Published: October 2017

An efficient and sustainable methodology for the synthesis of 1,3-diynes has been demonstrated using a Cu3(BTC)2 metal organic framework.
Extreme halophilic alcohol dehydrogenase mediated highly efficient syntheses of enantiopure aromatic alcohols
Authors: Alsafadi Diya , Alsalman Safaa , Paradisi Francesca
Published: October 2017

Alcohol dehydrogenase from the extreme halophile Haloferax volcanii (HvADH2) catalysed asymmetric reduction of a range of structurally diverse aromatic ketones with co-factor recycling.
The one-pot synthesis of quinolines via Co(iii)-catalyzed C–H activation/carbonylation/cyclization of anilines
Authors: Xu Xuefeng , Yang Yurong , Chen Xin , Zhang Xu , Yi Wei
Published: October 2017

A new and versatile Co(iii)-catalyzed C–H activation/carbonylation/cyclization cascade reaction has been disclosed.
An asymmetric acetate-Mannich reaction of chiral isatin derived ketimines and its applications
Authors: Hajra Saumen , Bhosale Suhas Shivajirao , Hazra Atanu
Published: October 2017

A highly efficient TMSOTf-mediated asymmetric acetate-Mannich reaction of chiral isatin derived ketimines and S-phenyl thioacetate was developed to afford the direct synthesis of indole-based β3,3-amino acid thioester with excellent selectivity (dr > 98 : 2). Syntheses of (+)-AG-041R and 3-aminopyrroloindoline have been accomplished utilizing the method.
Structural and magnetic susceptibility characterization of Pu(v) aqua ion using sonochemistry as a facile synthesis method
Authors: Dalodière Elodie , Virot Matthieu , Dumas Thomas , Guillaumont Dominique , Illy Marie-Claire , Berthon Claude , Guerin Laëtitia , Rossberg André , Venault Laurent , Moisy Philippe , Nikitenko Sergey I.
Published: October 2017

The facile sonochemical preparation of pure, stable and concentrated Pu(v) aqueous solutions allowed to investigate its solvation environment and magnetic properties.
Structural predictions for curli amyloid fibril subunits CsgA and CsgB
Authors: DeBenedictis E. P. , Ma D. , Keten S.
Published: October 2017

CsgA are the building blocks of curli fibrils.
Facile synthesis of CuMAl (M = Cr, Mn, Zn, and Co) with highly dispersed Cu and tailorable surface acidity for efficient 2-methylpyrazine synthesis
Authors: Hou Jindou , Luo Wen. , Luo Shizhong , Lin Chao , Liu Ping , Liao Xuemei , Jing FangLi , Li Xiaopeng
Published: October 2017

Synthesis of 2-methylpyrazine requires the well-designed CuMAl catalysts with bifunctional sites. Through alternating M species (M = Cr, Mn, Zn, and Co), highly dispersed Cu0 and high surface acidity can be achieved, thereby approaching the optimized catalytic performance.
Application of biochar-based catalysts in biomass upgrading: a review
Authors: Cao Xuefei , Sun Shaoni , Sun Runcang
Published: October 2017

The application of biochars as versatile catalysts and/or catalyst supports for biomass upgrading is systematically overviewed.
Synthesis of sustainable lignin-derived mesoporous carbon for supercapacitors using a nano-sized MgO template coupled with Pluronic F127
Authors: Song Yaoguang , Liu Junli , Sun Kang , Xu Wei
Published: October 2017

Sustainable lignin-derived mesoporous carbon for supercapacitors by simultaneously employing MgO nanoparticles and Pluronic F127 as templates.
Dissected carbon nanotubes functionalized by 1-hydroxyanthraquinone for high-performance asymmetric supercapacitors
Authors: Yang Xia , Yang Yuying , Zhang Quancai , Wang Xiaotong , An Yufeng , Guo Bingshu , Hu Zhongai , Wu Hongying
Published: October 2017

1-Hydroxyanthraquinone (HAQ) is selected to functionalize the dissected carbon nanotubes (rDCNTs) with reduced graphene oxide layers through non-covalent modification. The composite achieves high specific capacitance and ultrahigh rate capability.
The effects of He clusters on the mechanical properties of Ti3AC2 (A = Ge, Si): first-principles studies
Authors: Song Quan , Zhang Peng , Zhuang Jun , Ning Xi-Jing
Published: October 2017

The He clusters would easily form in the A layer and severely strengthen the embrittlement of Ti3AC2 (A = Ge, Si).
Enzymatic hydrogelation of self-assembling peptide I4K2and its antibacterial and drug sustained-release activities
Authors: Bai Jingkun , Gong Zhongying , Wang Jingxin , Wang Chengdong
Published: October 2017

I4K2hydrogel induced by plasma amine oxidase (PAO) has antibacterial and drug sustained-release properties.
Aldol condensation of acetic acid with formaldehyde to acrylic acid over Cs(Ce, Nd) VPO/SiO2 catalyst
Authors: Wang Aili , Hu Jing , Yin Hengbo , Lu Zhipeng , Xue Wuping , Shen Lingqin , Liu Shuxin
Published: October 2017

The Cs-, Ce-, and Nd-modified VPO/SiO2 exhibited higher activity for aldol condensation of acetic acid with formaldehyde to acrylic acid.
Molecular dynamic simulation of nanocrystal formation and tensile deformation of TiAl alloy
Authors: Li Peng-tao , Yang Yan-Qing , Xia Zhenhai , Luo Xian , Jin Na , Gao Yong , Liu Gang
Published: October 2017

The formation of BCC structure in the melt was the key in TiAl crystalline nucleation, and liquid TiAl alloy completely crystallized at the quenching rate of 0.02 K ps−1.
Natural terpenoid glycosides with in vitro/vivo antithrombotic profiles from the leaves of Crataegus pinnatifida
Authors: Gao Pin-Yi , Li Ling-Zhi , Liu Ke-Chun , Sun Chen , Sun Xue , Wu Ya-Nan , Song Shao-Jiang
Published: October 2017

Two norditerpenoids (1–2) with unique carbon skeletons, four sesquiterpenoids (3–6) and nine nor-sesquiterpenoids (7–15) were isolated from the leaves of Crataegus pinnatifida and evaluated as possessing antithrombotic activities in vitro/vivo.
Catalysis with chalcogen bonds: neutral benzodiselenazole scaffolds with high-precision selenium donors of variable strength
Authors: Benz Sebastian , Mareda Jiri , Besnard Céline , Sakai Naomi , Matile Stefan
Published: October 2017

Benzodiselenazoles are introduced for efficient anion binding and unprecedented non-covalent catalysis in the focal point of neutral selenium-based chalcogen-bond donors.
Auxeticity enhancement due to size polydispersity in fcc crystals of hard-core repulsive Yukawa particles
Authors: Pigłowski Paweł M. , Narojczyk Jakub W. , Wojciechowski Krzysztof W. , Tretiakov Konstantin V.
Published: October 2017

In this work we present results of Monte Carlo simulations of the elastic properties of Yukawa crystals with the polydispersity of size of particles. The results of our studies reveal an enhancement of negative Poisson's ratio (further referred to as auxeticity) due to size polydispersity in the system. We introduce a measure of auxeticity to estimate quantitatively an enhancement of auxetic properties which can be used to assess those changes in various systems.
Ultra-long lifetime water bubbles stabilized by negative pressure generated between microparticles
Authors: Yang Jin , Wang Ao , Zheng Quanshui
Published: October 2017

Negative pressure generated between microparticles can help water bubbles last over months and balance out evaporation water loss.
Hierarchically porous-structured ZnxCo1−xS@C–CNT nanocomposites with high-rate cycling performance for lithium-ion batteries
Authors: Wang Hao , Chen Ziliang , Liu Yang , Xu Hongbin , Cao Licheng , Qing Huilin , Wu Renbing
Published: October 2017

Hybrid nanocomposites constructed from starfish-like ZnxCo1−xS rooted in porous carbon and strongly coupled carbon nanotubes have been rationally designed and they exhibit excellent lithium-storage performance.
Solution synthesis of few-layer WTe2and MoxW1−xTe2nanostructures
Authors: Sun Yifan , Fujisawa Kazunori , Terrones Mauricio , Schaak Raymond E.
Published: October 2017

Colloidal nanostructures of WTe2and MoxW1−xTe2alloys were synthesized and characterized; multiple stacking motifs co-exist in WTe2, and the crystal structure can be tuned as a function of composition in MoxW1−xTe2.
Electrical and electrochemical characterization of proton transfer at the interface between chitosan and PdHx
Authors: Robinson J. T. , Pietron J. J. , Blue B. , Perkins F. K. , Josberger E. , Deng Y. , Rolandi M.
Published: October 2017

Advancing electronic devices that interface with biology will require a thorough understanding of the electrochemical pathways that transduce electronic currents into the ionic currents.
Temperature-dependent properties of monolayer MoS2 annealed in an Ar diluted S atmosphere: an experimental and first-principles study
Authors: Wang Lei , Ji Xiaohong , Chen Fei , Zhang Qinyuan
Published: October 2017

Monolayer MoS2 annealed under an Ar diluted S atmosphere exhibited novel structural and optical properties.
A detailed X-ray investigation of ζ Puppis
Authors: Nazé Yaël , Ramiaramanantsoa Tahina , Stevens Ian R. , Howarth Ian D. , Moffat Anthony F. J.
Published: October 2017

Context. One of the optically brightest and closest massive stars, ζ Pup, is also a bright X-ray source. Previously, its X-ray emission was found to be variable with light curves harbouring “trends” with a typical timescale longer than the exposure length, i.e. >1 d. The origin of these changes was proposed to be linked to large-scale structures in the wind of ζ Pup, but further characterization of the variability at high energies was needed to investigate this scenario.

Aims. Since the previous papers of this series, a number of new X-ray observations have become available. Furthermore, a cyclic behaviour with a 1.78 d period was identified in long optical photometric runs, which is thought to be associated with the launching mechanism of large-scale wind structures.

Methods. We analysed these new X-ray data, revisited the old data, and compared the X-ray light curves with the optical data, notably those taken simultaneously.

Results. The behaviour of ζ Pup in X-rays cannot be explained in terms of a perfect clock because the amplitude and shape of its variations change with time. For example, ζ Pup was much more strongly variable between 2007 and 2011 than before and after this interval. Comparing the X-ray spectra of the star at maximum and minimum brightness yields no compelling difference beyond the overall flux change: the temperatures, absorptions, and line shapes seem to remain constant, well within errors. The only common feature between X-ray datasets is that the variation amplitudes appear maximum in the medium (0.6–1.2 keV) energy band. Finally, no clear and coherent correlation can be found between simultaneous X-ray and optical data. Only a subgroup of observations may be combined coherently with the optical period of 1.78 d, although the simultaneous optical behaviour is unknown.

Conclusions. The currently available data do not reveal any obvious, permanent, and direct correlation between X-ray and optical variations. The origin of the X-ray variability therefore still needs to be ascertained, highlighting the need for long-term monitoring in multiwavelengths, i.e. X-ray, UV, and optical.
Preparation of Aryl(dicyclohexyl)phosphines by C–P Bond-Forming Cross-Coupling in Water Catalyzed by an Amphiphilic-Resin-Supported Palladium Complex
Authors: Hirai Yoshinori , Uozumi Yasuhiro
Published: October 2017

Aryl(dicyclohexyl)phosphines were prepared by a catalytic C–P bond-forming cross-coupling reaction of haloarenes with dicyclohexylphosphine under heterogeneous conditions in water containing an immobilized palladium complex coordinated to an amphiphilic polystyrene–poly(ethylene glycol) resin supported di(tert-butyl)phosphine ligand.
The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial: A Story of Discovery
Authors: Connell Matthew , Sjaarda Lindsey , Radin Rose , Kuhr Daniel , Mumford Sunni , Plowden Torie , Silver Robert , Schisterman Enrique
Published: October 2017

Human reproduction is an inefficient process. There are several drivers of complications along the path to and during pregnancy, one of which is inflammation. Treatments to mitigate the deleterious effects of aberrant inflammation with something inexpensive and widely available like aspirin could have dramatic global impact. The Effects of Aspirin in Gestation and Reproduction (EAGeR) trial enrolled women aged 18 to 40 years with one to two prior pregnancy losses and no diagnosis of infertility. Patients were randomized to either low-dose aspirin or placebo. Here, we review the collective findings of the EAGeR trial to date and discuss several important lessons learned from the unique data resulting from this groundbreaking trial. Findings reported from this trial provide significant advances in the understanding of aspirin's potential mechanisms in modulating reproductive processes and the role of inflammation in these processes. This review describes the collective findings of the EAGeR trial in the context of the existing literature regarding aspirin and inflammation in reproduction to inform relevant next steps in fertility and obstetric research, as well as potential implications for clinical care.