bluuebunny/crossref_metadata_2025 huggingface dataset:
JHD205, A Novel Abemaciclib Derivative, Exerts Antitumor Effects on Breast Cancer
by CDK4/6
Authors: Ji Jing , Qin Jingting , Wang Xiaoshuo , Lv Mingxiao , Hou Xiao , Jing Aixin , Zhou Jiaojiao , Zuo Lingyi , Liu Wenwen , Feng Jing , Qian Qilan , Liu Yuanyuan , Wang Xiujun , Liu Bin
Published: January 2024

Background:

Efficient targeted molecular therapeutics are needed for the treatment of triple-negative
breast cancer (TNBC), a highly invasive and difficult-to-treat form of breast cancer associated with a poor prognosis.

Objectives:

This study aims to evaluate the potential of selective CDK4/6 inhibitors as a therapeutic option for
TNBC by impairing the cell cycle G1 phase through the inhibition of retinoblastoma protein (Rb) phosphorylation.

Methods:

In this study, we synthesized a compound called JHD205, derived from the chemical structure of
Abemaciclib, and examined its inhibitory effects on the malignant characteristics of TNBC cells.

Results:

Our results demonstrated that JHD205 exhibited superior tumor growth inhibition compared to Abemaciclib
in breast cancer xenograft chicken embryo models. Western blot analysis revealed that JHD205 could dosedependently
degrade CDK4 and CDK6 while also causing abnormal changes in other proteins associated with
CDK4/6, such as p-Rb, Rb, and E2F1. Moreover, JHD205 induced apoptosis and DNA damage and inhibited
DNA repair by upregulating Caspase3 and p-H2AX protein levels.

Conclusion:

Collectively, our findings suggest that JHD205 holds promise as a potential treatment for breast
carcinoma.
Study of Access Control Techniques on the Blockchain-enabled Secure
Data Sharing Scheme in Edge Computing
Authors: Mathur Neha , Sinha Shweta , Tyagi Rajesh Kumar , Jatana Nishtha
Published: January 2024

Background:

The pervasive adoption of edge computing is reshaping real-time big
data analysis, smart city management, intelligent transportation, and various other domains. Its
appeal lies in its distributed nature, decentralization, low latency, mobile support, and spatial
awareness. However, this ubiquity exposes data to security threats, jeopardizing privacy and
integrity. Consequently, access control assumes paramount importance in securing data sharing
within edge computing and blockchain technologies.

Methods:

This research addresses this critical issue by conducting a comprehensive study on
access control techniques within the context of edge computing and blockchain for secure data
sharing. Our methodology commences with an exhaustive review of relevant articles, aiming to
identify and expound upon gaps in existing research. Subsequently, we perform a meticulous
analysis of access control methods, mechanisms, and performance metrics, seeking to establish
a holistic understanding of the landscape.

Results:

The culmination of this research effort is a multifaceted contribution. We distill insights from a diverse range of access control schemes, shedding light on their nuances and effectiveness. Our analysis extends to evaluating the performance metrics vital for ensuring robust access control. Through this research, we also pinpoint critical research gaps within traditional access control methods, creating a foundation for innovative approaches to address the
evolving challenges within edge computing and blockchain environments.

Conclusion:

In conclusion, this research venture paves the way for secure data sharing in edge
computing and blockchain by offering a thorough examination of access control. The findings
from this study are anticipated to guide future developments in access control techniques and
facilitate the evolution of secure, privacy-conscious, and efficient data sharing practices in the
dynamic landscape of digital technology.
Pengaruh Penggunaan Multimedia Interaktif Berbasis Adobe Flash terhadap Peningkatan Prestasi Belajar Tema 5 Anak Tunagrahita Ringan Kelas 5 di SLB Negeri Surakarta Tahun Pelajaran 2016/2017
Authors: Arfani Fariz Riza
Published: January 2024

The aim of this research is to determine the effect of the use of adobe flash based multimedia towards the increase of thematic learning achievement of five 5th graders with light intellectual disability in SLB Negeri Surakarta, academic year 2016/2017.This research using quantitative approach with One-group pretest-posttest design pre-experimental design. The subjects involved in this research were five 5th graders with light intellectual disability in SLB Negeri Surakarta. Data is colleted using a multiple choice objective tests. Data analyzed using non-parametric statistics through Wilcoxon Sign Rank test with the help of a software namely SPSS 23. Based on the analysis of descriptive data obtained the average score as much as 52.00 in the pretest and 82.00 in the posttest.The non-parametric statistics results of Wilcoxon Sign Rank Test note that the value of Z values = -2.041 with Asymp Sig (2-tailed) = 0,041 is smaller than a predetermined significance level or 0.041 < 0.05, so the alternative hypothesis is accepted and the null hypothesis is accepted. Based on the analysis result of this research we can conclude that the use of adobe flash based interactive multimedia affect the achievement of thematic learning towards five 5th graders with light intellectual disability in SLB Negeri Surakarta academic year 2016/2017.
Meaningful Work and Disability: A Dignity Towards Social Inclusion
Authors: Rosdianti Yeni
Published: January 2024

Access to employment is essential for every persons including persons with disabilities. If a meaningful work is enormously important, how does an equality framework advance this in securing access to the labour market? This paper will examine the way in which work is significant for persons with disabilities as a pathway towards social inclusion. It is apparantly drawn from the concept of dignity, equality and human rights. Accordingly, a substantive equality approach provides a powerful endowment to the fulfilment of the right to work of persons with disability.
Aksesibilitas bagi Anak Berkebutuhan Khusus dalam Lingkup Pendidikan Sekolah Inklusi di Karisidenan Surakarta
Authors: Al Khakim Abwatie , Prakosha Donni , Himawanto Dwi Aries
Published: January 2024

This research aims to identify condition of inclusive school in Solo especially for handicapped children. This is a qualitative research. Focuses of this research are first, the accessibility of inclusive school and second, identifying ideal inclusive school for handicapped children. it is located in two schools namely at Al Firdaus High School of Sukoharjo and Brumantakan Elementary School Solo. Method to collect data is observation, interview, and documentation. Conclusion drawn from this research is accessibility of inclusive school for handicapped children is not fulfilled completely. There is still barrier in completing condition of good and proper accessibility in inclusive school.
Aksesibilitas bagi Difabel pada Bangunan Hotel di Kota Surakarta
Authors: Latifah Siti
Published: January 2024

The purpose of this study was to describe the accessibility of hotels for difable in Surakarta. The object of this study was two hotels in Surakarta. The research used qualitative approaches. Data collected by observation, interview, and documentation. We found that percentage of accessiblity of both hotels are around 60-70%. There is still barrier in completing condition of good and proper accessibility in hotels.
Perkecambahan Biji Buah Naga Merah (Hylocereus polyrhizus) dengan Variasi Konsentrasi Ekstrak Tomat (Solanum lycopersicum L.) dan Lama Waktu Perendaman
Authors: Indrasari Dita , Zakiah Zulfa , Gusmalawati Dwi
Published: January 2024

Buah naga merupakan tanaman yang dapat diperbanyak secara vegetatif dan generatif. Perbanyakan buah naga secara generatif menggunakan biji dihadapkan pada permasalahan adanya lendir yang mengelilingi biji dan biji berukuran kecil. Biji berukuran kecil, memiliki endosperm sedikit sehingga cadangan makanan terbatas dan pertumbuhan menjadi lambat. Salah satu cara yang dapat digunakan untuk mempercepat proses perkecambahan adalah dengan merendam biji menggunakan zat pengatur tumbuh (zpt). Ekstrak tomat merupakan salah satu sumber zpt alami yang dapat mempercepat perkecambahan biji. Tujuan penelitian ini adalah untuk mengetahui pengaruh konsentrasi ekstrak tomat dan lama waktu perendaman terhadap perkecambahan biji buah naga. Bahan yang digunakan pada penelitian ini, yaitu aquades, biji buah naga (Hylocereus polyrhizus), ekstrak buah tomat (Solanum lycopersicum L. var. intan). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial yang terdiri dari dua faktor, yaitu konsentrasi ekstrak tomat dan waktu perendaman. Faktor pertama, konsentrasi ekstrak tomat (T), yaitu terdiri dari Kontrol (T0), 4% (T1), 6% (T2), 8% (T3), dan 10% (T4). Faktor kedua lama perendaman (P), yaitu Kontrol (P0), 6 Jam (P1), 12 Jam (P2), 24 Jam (P3), 48 Jam (P4). Penelitian dilaksanakan di Laboratorium Biologi Umum, Jurusan Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tanjungpura, Pontianak. Penelitian dilakukan pada bulan Agustus hingga September 2022. Hasil penelitian menunjukkan bahwa waktu perendaman 48 jam merupakan waktu terbaik pada parameter persentase perkecambahan (74,8%), waktu muncul kecambah (3,96 hst), dan panjang radikula (0,29 cm). Konsentrasi ekstrak tomat 10% merupakan konsentrasi terbaik pada parameter waktu muncul kecambah. Kombinasi konsentrasi ekstrak tomat dan lama waktu perendaman memberikan hasil tidak berpengaruh nyata terhadap semua parameter pengamatan.
Technical Indicators of Major Healthcare Companies: A Comprehensive Analysis
Authors: Mehta Rohit , Khan Sofia , Singh Ashutosh Kumar
Published: January 2024

This research aims to provide a comprehensive analysis of major healthcare stocks along with the nifty health care index within the healthcare sector. Employing technical indicators such as the Moving Average Convergence Divergence (MACD), Rate of Change (ROC) and Relative Strength Index (RSI) we conduct a detailed trend analysis to identify historical patterns and potential turning points in stock prices. Furthermore, advanced time series forecasting models and predictive analytics are utilized to forecast future share prices for the selected three companies, offering valuable insights for investors and market participants.

In addition, we investigate the relationship between the stock prices of Apollo Hospital, Fortis Healthcare & Narayana Hruda and the Nifty Healthcare Index. This analysis sheds light on how individual stock prices are influenced by broader sectoral performance. We also explore the impact of MACD, ROC, and RSI technical indicators on the prices of all healthcare stocks through rigorous statistical analysis. Our findings provide healthcare sector stakeholders with a deeper understanding of stock behaviour, potential future movements, correlations with market indices and risk assessment.

The results of this study enhance the decision-making process for investors and market participants in the healthcare sector. By examining historical trends, forecasting price dynamics, assessing sectoral correlations, evaluating technical indicator effects and risk measurement, this research contributes to a more comprehensive view of these stocks and their positioning within the healthcare industry.
Avances de investigación en nutrición, manejo y control de enfermedades en el cultivo de uchuva
Authors: Ramírez Gómez María Margarita , Serralde Ordóñez Diana Paola , Nuñez Zarantes Víctor Manuel , Martinez Lemus Érika Patricia , Gonzalez Almario Carolina , Peñaranda Rolón Andrea María , Zapata Narváez Yimmy Alexander , García Arias Francy Liliana , Rodríguez Puertas David , Rodríguez Velásquez Edwin Alirio , Díaz García Andrés , Mayorga Cubillos Franklin Giovanni , Rojas Zambrano Emerson Duván , Pulido Blanco Víctor Camilo , Beltrán Acosta Camilo Rubén , Sánchez Betancourt Érika Patricia , Martínez Camelo Fabián Enrique , Barbosa Medina Johan David , Wilches Ortiz Wilmar Alexander , Clímaco Hio Juan , Burbano David Diana Marcela , Caro Quintero Alejandro , Sanabria Torres Camilo Ernesto , Alarcón Ramírez Andrés , Duarte Carvajalino Julio Martín
Published: January 2024

Este libro se concibe como un material de consulta para productores, exportadores, académicos, estudiantes y demás actores interesados en el cultivo de la uchuva. Es la consolidación de un esfuerzo colectivo de un grupo interdisciplinario de investigadores de AGROSAVIA, quienes desde su área de conocimiento y experiencia han sumado esfuerzos para buscar alternativas que contribuyan a la sostenibilidad y competitividad del cultivo de uchuva en Colombia. En esta publicación, el lector puede encontrar los principales avances conseguidos en torno a este sistema productivo.
The Migrant-Local Difference in the Relationship Between Social Support, Sleep Disturbance, and Loneliness Among Older Adults in China: Cross-Sectional Study (Preprint)
Authors: Pang Mingli , Wang Jieru , Zhao Mingyue , Chen Rui , Liu Hui , Xu Xixing , Li Shixue , Kong Fanlei
Published: January 2024

BACKGROUND

Driven by the accelerated aging of the population of China, the number of older adults has increased rapidly in the country. Meanwhile, following children, migrant older adults (MOA) have emerged as a vulnerable group in the process of fast urbanization. Existed studies have illustrated the association between social support and loneliness and the relationship between sleep disturbance and loneliness; however, the underlying mechanisms and the migrant-local difference in the association between social support, sleep disturbance, and loneliness have not been identified.

OBJECTIVE

This study aimed to clarify the migrant-local difference in the relationship between social support, sleep disturbance, and loneliness in older adults in China.

METHODS

Multistage cluster random sampling was used to select participants: 1205 older adults (n=613, 50.9%, MOA and n=592, 49.1%, local older adults [LOA]) were selected in Weifang City, China, in August 2021. Loneliness was assessed with the 6-item short-form University of California, Los Angeles Loneliness Scale, social support was evaluated with the Social Support Rating Scale, and sleep disturbance was measured with the Pittsburgh Sleep Quality Index. The chi-square test, t test, and structural equation modeling (SEM) were adopted to explore the migrant-local difference between social support, sleep disturbance, and loneliness among the MOA and LOA.

RESULTS

The mean score of loneliness was 8.58 (SD 3.03) for the MOA and 8.00 (SD 2.79) for the LOA. SEM analysis showed that social support exerts a direct negative effect on both sleep disturbance (standardized coefficient=–0.24 in the MOA and –0.20 in the LOA) and loneliness (standardized coefficient=–0.44 in the MOA and –0.40 in the LOA), while sleep disturbance generates a direct positive effect on loneliness (standardized coefficient=0.13 in the MOA and 0.22 in the LOA).

CONCLUSIONS

Both MOA and LOA have a low level of loneliness, but the MOA show higher loneliness than the LOA. There is a negative correlation between social support and loneliness as well as between social support and sleep disturbance among the MOA and LOA (MOA>LOA), while loneliness is positively associated with sleep disturbance in both populations (MOA<LOA). Measures should be taken by the government, society, and families to increase social support, decrease sleep disturbance, and further reduce the loneliness among older adults, especially the MOA.
Reducing the Number of Intrusive Memories of Work-Related Traumatic Events in Frontline Health Care Staff During the COVID-19 Pandemic: Case Series (Preprint)
Authors: Kubickova Veronika , Steel Craig , Moulds Michelle L , Kanstrup Marie , Beer Sally , Darwent Melanie , Keating Liza , Holmes Emily A , Iyadurai Lalitha
Published: January 2024

BACKGROUND

Frontline health care staff are frequently exposed to traumatic events as part of their work. Although this study commenced before the emergence of COVID-19, levels of exposure were heightened by the pandemic. Many health care staff members report intrusive memories of such events, which can elicit distress, affect functioning, and be associated with posttraumatic stress disorder symptoms in the long term. We need evidence-based interventions that are brief, preventative, nonstigmatizing, suitable for the working lives of frontline health care staff, and effective for repeated trauma exposure. A brief, guided imagery-competing task intervention involving a trauma reminder cue and Tetris gameplay may hold promise in this regard, given evidence that it can prevent and reduce the number of intrusive memories following trauma across various settings.

OBJECTIVE

This case series aims to investigate the impact of a brief imagery-competing task intervention on the number of intrusive memories, general functioning, and symptoms of posttraumatic stress, anxiety, and depression, and examine the feasibility and acceptability of the intervention for UK National Health Service frontline health care staff. The intervention was delivered with guidance from a clinical psychologist.

METHODS

We recruited 12 clinical staff from the UK National Health Service, specifically from emergency departments, the intensive care unit, and the ambulance service. We evaluated the intervention using an AB single-case experimental design, where the baseline (A) was the monitoring-only phase and the postintervention (B) period was the time after the intervention was first administered. Methods were adapted once the COVID-19 pandemic began.

RESULTS

There was a decrease (59%) in the mean number of intrusive memories per day from baseline (mean 1.29, SD 0.94) to postintervention (mean 0.54, SD 0.51). There was a statistically significant reduction in the number of intrusive memories from baseline to postintervention, as shown by an aggregated omnibus analysis with a small effect size (τ-U=–0.38; P<.001). Depression, anxiety, and posttraumatic stress symptoms all significantly reduced from preintervention to postintervention. Participants also reported improvements in functioning based on both quantitative and qualitative measures. The intervention was feasible to deliver and rated as acceptable by participants.

CONCLUSIONS

These preliminary findings suggest that this brief therapist-guided imagery-competing task intervention offers a potential approach to mitigating the impact of work-related traumatic events in frontline health care staff, both during a pandemic and beyond. Randomized controlled trials will be an important next step.
Correction: Dashboard With Bump Charts to Visualize the Changes in the Rankings of Leading Causes of Death According to Two Lists: National Population-Based Time-Series Cross-Sectional Study (Preprint)
Authors: Tai Shu-Yu , Chi Ying-Chen , Chien Yu-Wen , Kawachi Ichiro , Lu Tsung-Hsueh
Published: January 2024

BACKGROUND

Health advocates and the media often use the rankings of the leading causes of death (CODs) to draw attention to health issues with relatively high mortality burdens in a population. The National Center for Health Statistics (NCHS) publishes “Deaths: leading causes” annually. The ranking list used by the NCHS and statistical offices in several countries includes broad categories such as cancer, heart disease, and accidents. However, the list used by the World Health Organization (WHO) subdivides broad categories (17 for cancer, 8 for heart disease, and 6 for accidents) and classifies Alzheimer disease and related dementias and hypertensive diseases more comprehensively compared to the NCHS list. Regarding the data visualization of the rankings of leading CODs, the bar chart is the most commonly used graph; nevertheless, bar charts may not effectively reveal the changes in the rankings over time.

OBJECTIVE

The aim of this study is to use a dashboard with bump charts to visualize the changes in the rankings of the leading CODs in the United States by sex and age from 1999 to 2021, according to 2 lists (NCHS vs WHO).

METHODS

Data on the number of deaths in each category from each list for each year were obtained from the Wide-ranging Online Data for Epidemiologic Research system, maintained by the Center for Disease Control and Prevention. Rankings were based on the absolute number of deaths. The dashboard enables users to filter by list (NCHS or WHO) and demographic characteristics (sex and age) and highlight a particular COD.

RESULTS

Several CODs that were only on the WHO list, including brain, breast, colon, hematopoietic, lung, pancreas, prostate, and uterus cancer (all classified as cancer on the NCHS list); unintentional transport injury; poisoning; drowning; and falls (all classified as accidents on the NCHS list), were among the 10 leading CODs in several sex and age subgroups. In contrast, several CODs that appeared among the 10 leading CODs according to the NCHS list, such as pneumonia, kidney disease, cirrhosis, and sepsis, were excluded from the 10 leading CODs if the WHO list was used. The rank of Alzheimer disease and related dementias and hypertensive diseases according to the WHO list was higher than their ranks according to the NCHS list. A marked increase in the ranking of unintentional poisoning among men aged 45-64 years was noted from 2008 to 2021.

CONCLUSIONS

A dashboard with bump charts can be used to improve the visualization of the changes in the rankings of leading CODs according to the WHO and NCHS lists as well as demographic characteristics; the visualization can help users make informed decisions regarding the most appropriate ranking list for their needs.
Integrating Social Determinants of Health in Machine Learning–Driven Decision Support for Diabetes Case Management: Protocol for a Sequential Mixed Methods Study (Preprint)
Authors: Lee Seung-Yup , Hayes Leslie W , Ozaydin Bunyamin , Howard Steven , Garretson Alison M , Bradley Heather M , Land Andrew M , DeLaney Erin W , Pritchett Amy O , Furr Amanda L , Allgood Ashleigh , Wyatt Matthew C , Hall Allyson G , Banaszak-Holl Jane C
Published: January 2024

BACKGROUND

The use of both clinical factors and social determinants of health (SDoH) in referral decision-making for case management may improve optimal use of resources and reduce outcome disparities among patients with diabetes.

OBJECTIVE

This study proposes the development of a data-driven decision-support system incorporating interactions between clinical factors and SDoH into an algorithm for prioritizing who receives case management services. The paper presents a design for prediction validation and preimplementation assessment that uses a mixed methods approach to guide the implementation of the system.

METHODS

Our study setting is a large, tertiary care academic medical center in the Deep South of the United States, where SDoH contribute to disparities in diabetes-specific hospitalizations and emergency department (ED) visits. This project will develop an interpretable artificial intelligence model for a population with diabetes using SDoH and clinical data to identify which posthospitalization cases have a higher likelihood of subsequent ED use. The electronic health record data collected for the study include demographics, SDoH, comorbidities, hospitalization-related factors, laboratory test results, and medication use to predict posthospitalization ED visits. Subsequently, a mixed methods approach will be used to validate prediction outcomes and develop an implementation strategy from insights into patient outcomes from case managers, clinicians, and quality and patient safety experts.

RESULTS

As of December 2023, we had abstracted data on 174,871 inpatient encounters between January 2018 and September 2023, involving 89,355 unique inpatients meeting inclusion criteria. Both clinical and SDoH data items were included for these patient encounters. In total, 85% of the inpatient visits (N=148,640) will be used for training (learning from the data) and the remaining 26,231 inpatient visits will be used for mixed-methods validation (testing).

CONCLUSIONS

By integrating a critical suite of SDoH with clinical data related to diabetes, the proposed data-driven risk stratification model can enable individualized risk estimation and inform health professionals (eg, case managers) about the risk of patients’ upcoming ED use. The prediction outcome could potentially automate case management referrals, helping to better prioritize services. By taking a mixed methods approach, we aim to align the model with the hospital’s specific quality and patient safety considerations for the quality of patient care and the optimization of case management resource allocation.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/56049
From Religious Hybridity to Indigenous Religion: Perubahan Paradigma dan Praktik Ritual Penghayat di Minahasa, Sulawesi Utara
Authors: Pinatik Hun Johanis Alfrits
Published: January 2024

Artikel ini mengeksplorasi perubahan paradigma dan praktik ritual agama hibrid menuju agama lokal yang terjadi karena peran agen perubahan sosial. Tulisan ini berfokus pada perubahan sosial dari dominasi Kekristenan menuju paradigma dan praktik ritual non-Kristen di Minahasa. Paradigma agama lokal merupakan dekonstruksi terhadap pendekatan agama dunia. Hal tersebut tidak dapat terlepas dari konteks modernitas yang membatasi dan mengkonstruksi dominasi terhadap agama lokal. Dalam mengkaji perubahan sosial akibat aspek modernitas, maka tulisan ini menggunakan teori social change dari Piotr Sztompka (2017) yang menawarkan perspektif modernitas dan agent of change. Selain itu, penelitian ini juga akan menggunakan perspektif Indigenous Religion Paradigm dari Samsul Maarif (2019) untuk menganalisis paradigma agama lokal Minahasa. Penelitian ini berbasis pada metode kualitatif dengan pendekatan studi kasus untuk menganalisis kasus perubahan paradigma dan praktik ritual Minahasa. Berbasis pada pendekatan studi kasus, maka penelitian ini akan dianalisis menurut pola, konteks, dan setting yang terjadi di lapangan, khususnya peran Tona’as pada proses perubahan paradigma dan praktik ritual. Data-data pendukung juga diperoleh melalui studi pustaka dan studi dokumenter untuk menggambarkan dan menganalisis peristiwa kasus perubahan agama di Minahasa. Argumentasi utama dalam tulisan ini bahwa, paradigma dan praktik ritual Minahasa telah mengalami perubahan sosial melalui dekonstruksi paradigma agama dunia yang hibrid oleh agen religius (Tona’as), sehingga  mengkonstruksi kembali paradigma agama lokal yang berbasis lokalitas.
Hereditary Tradition: Analyzing Connections among Detective Depictions in Texts by Poe, Doyle, and King using Harold Bloom’s Revisionary Ratios Theory
Authors: Zahroh Adiba Qonita
Published: January 2024

There has been a longstanding debate about the origin of detective fiction, with most recognizing Poe as its pioneer. However, there remains a need to comprehensively analyze the literary influence that spans across generations in detective fiction. This research introduces a comprehensive analysis of the literary influence that spans across generations in detective fiction, shedding light on the intricate web of connections between Edgar Allan Poe, Sir Arthur Conan Doyle, and Laurie R. King. Central to this investigation is the application of Harold Bloom’s theory of revisionary ratios, which serves as an invaluable analytical framework. Through the application of Harold Bloom’s theory of revisionary ratios, this research provides a comprehensive exploration of the enduring significance of intertextuality in shaping the detective fiction landscape. It underscores the intricate web of influences that connect Poe’s pioneering works with subsequent narratives by Conan Doyle and King. Having the enduring significance of intertextuality that shapes the detective fiction landscape, this study still offers a novel perspective on the genre’s dynamic evolution. The method involves a detailed review of revisionary ratio concepts and their implications for understanding complex literary works more thoroughly. The result reveals the enduring significance of revisionary ratios in understanding the complexities of literary works, with Edgar Allan Poe’s influence resonating in subsequent detective stories by Sir Arthur Conan Doyle and Laurie R. King.
Sovereign Power and Nuda Vita in Ruta Sepetys’s I Must Betray You: Unveiling the Struggles of Romanian Civilians In 1989
Authors: Rizki Geubrina , Huda Miftahul , Aziz Abdul
Published: January 2024

I Must Betray You (2022), a literary work by Ruta Sepetys, is a touching drawing of the painful experience suffered by Romanian civilians under Nicolae Ceauşescu’s regime in 1989. Through a rich tapestry of policies, regulations, and prohibitions, Ceauşescu bound Romanian life to nuda vita. This study aims to analyzes how Ruta Sepetys’ I Must Betray You illustrated the sovereign power that restrains Romanian civilians’ lives and how the civilians detached from nuda vita and the sovereign power. It employs a qualitative descriptive approach by drawing on the theoretical framework put forth by Giorgio Agamben. The framework encompasses crucial concepts such as sovereign power, the state of exception, and nuda vita. Notably, the sovereign power represents an authority to create laws but remains unbound. The state of exception refers to a blurred zone of “law and life”. Besides, nuda vita embodies the condition in which an individual’s life is vulnerable to death without being considered a sacrifice. The study reveals two primary findings. First, restrict any criticism directed at Ceauşescu, exiting Romania, gathering in groups of more than three individuals, engaging in conversations with foreigners, possessing typewriters, and many other prohibitions. The authorities also exercised rigid control over civilians’ basic needs, from access to electricity to food, and imposed strict laws. The sovereign power restrained Romanian civilians’ lives through various methods to instill fear, such as utilizing Phillips, i.e., tapping devices, widely spread within households. Second, the civilians’ revolts against the sovereign power and nuda vita were manifested through strategies like adopting a double-agent role, utilizing knowledge as propaganda, and building allies with soldiers. The novelty of this study proposes a path towards detachment from the sovereign power and nuda vita, particularly relevant to contemporary debates.
Mujeres trans* en San Cristóbal de Las Casas, Chiapas. Entre la hegemonía del sistema sexogénero, el discurso biomédico y la resignificación política
Authors: Gómez Irazú
Published: January 2024

En este artículo elaboro una reflexión alrededor del sistema sexo-género y su relación con el discurso biomédico respecto a las mujeres trans* en San Cristóbal de Las Casas, Chiapas. Ciudad de la frontera sur, en donde persiste una interacción sociocultural derivada de la norma binaria de género,  la cual reproduce contextos de desigualdad con afectaciones a este grupo poblacional. Para comprender algunas consecuencias de la dinámica referida, presento como caso de estudio la historia de vida de Flor, mujer trans*, tseltal, migrante local en la región Los Altos.
Familias que aceptan y acompañan a sus hijes trans*. Una aproximación a sus experiencias
Authors: Cruz Gutiérrez Dani Damián
Published: January 2024

Este artículo plantea una aproximación a los procesos que viven las familias que se decantan por un proceso de aceptacion y apoyo para sus hijes trans*. El proyecto, que se desprende de mi tesis doctoral, es de corte cualitativo con alcance descriptivo y parte de un posicionamiento epistemológico feminista. Tanto la metodología como el método se centraron en lo narrativo. Participaron cuatro niñes trans y sus familiares durante los años 2018 y 2019 en la Ciudad de México. Los resultados abonan a la evidencia señalando que las familias con un proceso de acompañamiento afirmativo fomentan la cercanía, confianza y comunicación con sus hijes, al tiempo que generan diversas estrategias de afrontamiento y negociación derivadas en aprendizajes mutuos. Las familias apuntalaron la salud emocional de sus hijes a través de acciones afirmativas como favorecer una comprensión positiva de lo trans, fomentar su participación en espacios seguros donde diversificaron sus referentes trans y generaron redes de apoyo entre pares desde las cuales se promueve el cuidado mutuo.
Assessing Prospects of Birth Rate in Russia with Governmental Encouragement of Grandparenting
Authors: Bagirova Anna , Shubat Oksana
Published: January 2024

The study develops and implements a methodology for assessing the prospects for increasing the birth rate, subject to state incentives for grandparental labor. This is understood as the activity of grandparents, during which the care and development of grandchildren are carried out and which is accompanied by the time costs of the grandparents, which, in turn, reduce the corres­ponding costs of parents for the implementation of parental labor. Grandparental labor has a certain content, it is associated with the expenditure of time and other resources of the progenitors, its activation implies a set of social, economic, demographic effects, one of which may be an increase

in the birth rate. We have developed a methodology for assessing such an effect under the condition of state stimulation of grandparental labor. Data collected during surveys of two categories of the population – parents and grandparents with children and grandchildren under the age of 12, respectively, were used as sources of information. The surveys were conducted in the Sverdlovsk Region in the summer of 2021. The main results of the analysis are as follows: a methodology has been developed that allows us to obtain quantitative estimates of the prospects for the growth of the Russian birth rate, subject to state incentives for the parental work of grandparents; partial testing of the developed methodology has allowed us to obtain estimates that allow us to positively assess the prospects for the growth of the Russian birth rate in the first approximation, subject to state incentives for the parental work of grandparents in relation to their grandchildren. The results of the study provide an opportunity to get a more complete picture of the effects of activating and introducing incentives for grandparental labor, create a basis for improving the indicators and measures of the federal project «Older Generation» of the national project «Demography».
Vocabulary of Traditional Material Culture in Languages of Southeast Asia
Authors: Dmitrenko Sergei
Published: January 2024

The article presents some findings of the research project "Traditional Material Culture Realia in Southeast Asia Languages and Folklore Texts". The main goal of the project is to show how the common for various South-East Asia populations material-culture elements are reflected in the areal languages — primarily, in their vocabulary. As an example of the research under the project, the article proposes an analysis of two lexemes for ‘gong’ and ‘cymbal’, respectively. Our research traces the “migration” of the corresponding terms bet­ween languages belonging to the various language families of the area (Austroasiatic, Austronesian, Sino-Tibetan, and Kra-Tai). Hypotheses on the ways of these lexemes’ distribution across the region are proposed. The article also describes the main results of our 2022 expedition to the north of Cambodia (a region inhabited by indigenous peoples of the Austroasiatic language family).
Teacher Agency and Reading Competency Development in Students
Authors: Borisenko Natalia
Published: January 2024

The research focuses on the development of reading competency in students from the standpoint of teacher agency. The importance of this article is justified by the function of reading as a key learning and academic achievement skill, as well as the fact that Russian pupils conti­nue to do poorly in text reading and comprehension. The authors present a reading competency

framework for general education that consists of five components: 1) reading ability; 2) high reading motivation; 3) ability to work with a book, basic reading skills (information search and analysis; text comprehension and interpretation; assessment of content and form); 4) extensive reading experience and desire to read extracurricular books; 5) willingness and ability to discuss what has been read orally and/or in writing. The researchers identify the teacher’s role in the development of each of the five components in general school children. It is demonstrated that a teacher with advanced agency skills shows a consistent interest in the development of students’ reading competency (motivational component); has relevant knowledge about the content of this competency and the methods of its development, teaches students book-working techniques (cognitive component); and enriches the classroom and school life with exciting reading activities (behavioural component).
Rus’ and the Golden Horde: Options for Reconstructing Economic Processes by Methods of Archaeozoology
Authors: Yavorskay Liliya
Published: January 2024

Our analysis of archaeozoological collections found on archaeological sites allowed to build a complex picture of the meat diet of medieval settlements in Eastern Europe and to reconstruct the structure of meat supply in Eastern European towns and villages in forest, forest-steppe and steppe areas, as well as to determine the similarities and differences in this structure across different landscapes and cultural zones. We found that the dominant meat in the diet of the medieval population in all studied landscapes, regardless of settlement form was beef. For Rus’ towns, which existed for several centuries, we identified the tendency to increase the share of beef in the meat diet from the early (12th century) to the latest (16th century and later) periods. Beef also dominated the meat consumption of townspeople in the Golden Horde in the 13th–14th centuries.

The study shows that cattle were raised in rural settlements and regularly delivered to the towns for hides and meat. Nomadic cattle, such as sheep and horses were delivered to the towns and slaughtered episodically to produce hides. In the artisanal quarters of the towns, our archaeozoological research registered accumulations of domestic ungulate bones with a specific taxonomic and anatomical set – the remains of large-scale slaughter of nomadic and rural livestock. These quarters also did the primary processing of hides – our study found clear markers of processing industries in archaeozoological collections. The study of isotopes (δ13C and δ15N) in more than 150 bone samples of domestic ungulates of forest and steppe areas proved the feasibility of using 13C isotope tags to capture the status of domestic ungulates: local and outsider; 15N isotope signals describe the contribution of farmed fodder to the diet of specific animals. We managed to discover the movement of nomadic steppe cattle from the arid zone for slaughtering and hides to the forest-steppe Bolgar town, and to record the fact of cattle exchange between steppe and forest territories, as well as between different regions of medieval Rus’.
Customer Profiling Model for Ecommerce Apps
Authors: Sujith K. , Azeez V. Abdul , Krishna M. Vamsi , Devanand S. , Sumanth K.
Published: January 2024

Abstract: Researchers are developing new ways to evaluate credit in e-commerce, combining traditional RFM analysis with machine learning such as SVM and random forests. This approach provides accurate information that distinguishes good customers from potential fraudsters, minimizing financial losses. Other models for online finance companies use clustering, advanced RFM feature selection, weighted averaging with logistic regression and random forest to better segment customers. These developments build on growing connections between traditional channels and technology between others, providing valuable insights for navigating today's financial challenges.
Design and Simulation of MEMS Surface Acoustic Wave Biosensor Based on PVDF Thin Film
Authors: Pattar Suraj , K J Rudresha
Published: January 2024

Abstract: Surface acoustic wave sensors, as a class of MEMS, are widely used recently. The sensor can transform an input electrical signal into a mechanical wave which can be easily influenced by physical phenomena. Then, the changed mechanical wave is transduced back into an electrical signal. The presence of the desired phenomenon can be detected through the difference between the input and output electrical signal (amplitude, phase, frequency, or time delay). The basic surface acoustic wave device consists of a piezoelectric substrate, an input interdigitated transducer (IDT) on one side of the surface of the substrate, and a second output interdigitated transducer on the other side of the substrate.
France - African States: some aspects of decentralized cooperation
Authors: Pakhorukov Konstantin I.
Published: January 2024

This study examines a new phenomenon in the history of relations between France and its former colonies - the implementation in recent years of decentralized cooperation programs with African states, in particular, the interaction of French regions, as administrativeterritorial units, with African partners. The study provides a brief overview of the history of the French colonial empire, which allowed the author to distinguish several stages in its management and functioning. The research method was the study of cooperation programs in various spheres initiated by the French Ministry of Foreign Affairs, state agencies, regional councils, as well as international associations of territorial entities, along with specific examples of cooperation, particularly the signing of agreements directly between the French regions and the central authorities of African nations. As a result of this study, the author concludes that experience of decentralization of France’s foreign policy activities can be partially used in the Russian Federation foreign policy practice.
Teaching methodology for modeling the activities of company within the discipline “Design of information systems”
Authors: Litvak Elena G.
Published: January 2024

Problem statement . The topic of modeling the activity of a company within the discipline “Design of information systems” remains one of the most difficult for students to understand. Students quickly master CASE tools and the syntax of graphic languages, but this is not enough to build correct models. Difficulties are associated with the lack of clear criteria for the correctness of the model and the many alternative solutions. The purpose of the study is to develop a methodology for teaching modeling, which will allow students to form a deeper understanding of the topic. Methodology . Experimental work was carried out on the basis of the Donetsk Academy of Management and Public Administration. In the experiment took part 79 students of the second year of bachelor's degree in the direction of training 09.03.03 “Applied informatics”. The experiment consisted of an anonymous questionnaire and statistical processing of its results. Results. Based on the analysis of typical mistakes of students, a “worksheet” has been developed, consisting of a number of empirical rules, which is recommended to be issued to students before starting to independently perform the simulation. Students are encouraged to constantly check for compliance of the constructed models with the proposed rules. The results of the experiment showed significant qualitative changes in the implementation of individual projects by students who used the proposed “worksheets”. Conclusion . The use of the described methodology in teaching students of the direction of training 09.03.03 “Applied informatics” within the discipline “Information systems design” provided a more conscious approach of students to modeling and, as a result, more correct performance of tasks.
Czechoslovak and Yugoslav Military Units Created in the USSR during the Great Patriotic War: Effectiveness Analysis
Authors: Sinitsyn Fedor L.
Published: January 2024

Based on the example of the history of the 1st Czechoslovak Army Corps and the 1st Yugoslav Infantry Brigade created on the territory of the USSR during the Great Patriotic War, there are revealed the peculiarities of the effectiveness of “foreign” military units on the territory of a third country. To date, these issues have not been sufficiently studied in historical science. The source base used in the research includes both published and unpublished documents from the funds of the Russian State Archive of Socio-Political History, the Russian State Military Archive and Central Archive of the Ministry of Defense of the Russian Federation. It is shown that despite similar conditions of the formation and assistance from the USSR, the destinies of the Czechoslovak army corps and the Yugoslav brigade were different. The former became a symbol of Czechoslovakia’s struggle against Nazism and the basis of the new Czechoslovak army, whereas the Yugoslav brigade underwent “reformatting”, “dissolved” in the People’s Liberation Army of Yugoslavia; it did not become the basis of the new Yugoslav army and then practically passed into oblivion. The author concludes that with regard to the effectiveness of the Czechoslovak army corps and the Yugoslav brigade, the decisive role was played by the relationship of their command with the main political participant in the process of creating these military units, on whose will both the achievement of the goals set and their very existence depended; the other factors were indirect.
Western Religious Propaganda in the Holy Land in the Correspondence of V.N. Khitrovo and K.P. Pobedonostsev in the 1880s
Authors: Blokhin Vladimir V.
Published: January 2024

The author has examined the correspondence of socio-religious figure and founder of the Imperial Orthodox Palestine Society (IOPS) V.N. Khitrovo with Chief Procurator of the Holy Synod K.P. Pobedonostsev in the 1880s; the problem of propaganda of the Catholic and Protestant churches in the Holy Land is explored. It is shown that in his detailed reports, historical essays and letters V.N. Khitrovo informed K.P. Pobedonostsev about threats to Orthodoxy in the Holy Land. V.N. Khitrovo rightly supposed that the success of Western propaganda was due to the Western powers’ implementation of their national interests. The religious policy of France and the Protestant powers (England and Germany) was a “tool” for promoting their national interests. “Propaganda” and religious penetration of Western faiths manifested themselves in religious and political forms, which was embodied in the creation of educational institutions, hospitals, the spread of semi-secular women’s orders, and the education of the local population. V.N. Khitrovo associated the success of Catholicism with the activities of Latin Patriarch I. Valerga. A special way of penetration into the Holy Land was biblical research, one example of which was the activities of Victorian General Gordon. V.N. Khitrovo considered that the weakening of Orthodoxy in the Holy Land was due to not only modest funding, but also insufficient coordination of secular and church institutions of the Russian Empire in the implementation of state religious policy. The author comes to the conclusion that the correspondents had trust-based relations and similar views on major religious and political issues.