bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris
Authors:   Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.  Email: Saraatta@aun.edu.eg, Atta Sara
Published: April 2024

Cytokines play a major role in the pathogenesis and progression of psoriasis. Interleukin (IL)-30 is a multifunctional cytokine. It binds to glycoprotein 130 (GP130) and inhibits the GP130 signaling pathways of psoriasis associated cytokines such as IL-6, IL-11, and IL-27. The study intended to assess associations of IL-30 and GP130 with the risk of psoriasis and Psoriasis Area Severity Index (PASI) score. Therefore, we measured the serum levels of IL-30 and GP130 in psoriasis patients and in a control group. An enzyme linked immunosorbent assay (ELISA) technique was used to measure IL-30 and GP130 levels in the serum of 43 patients and 43 normal controls. Statistical analysis of IL-30 and GP130 serum levels among patients and control groups and their correlation with PASI scores were performed. IL-30 serum levels showed a significant increase in patients with psoriasis compared with controls (p<0.001) and a positive correlation with PASI scores. While serum levels of GP130 were not different in psoriatic patients and in the control group. Furthermore, the receiver operating characteristic (ROC) curve showed that IL-30 had diagnostic ability for prediction of psoriasis in comparison to controls, at cut of point of >14.34 showed a sensitivity of 97.7%, 100% specificity. In conclusion, IL-30 was elevated in psoriasis patients than controls, therefore, it can be considered a sensitive biomarker for diagnosis of psoriasis.
Association between estrogen receptor alpha and aryl hydrocarbon receptor gene polymorphisms in the prognosis of breast cancer in Egypt
Authors:   Department of Biochemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt., Mohamed Faten
Published: April 2024

Breast cancer is the most malignant tumor among women in the world. Single nucleotide polymorphisms (SNPs) might better predict breast cancer prognosis. PvuII (T/C substitution), XbaI (A/G substitution), and aryl hydrocarbon (AhR) (G/A substitution) were evaluated as possible genetic prognostic factors for breast cancer. The aim of the current study was to assess the relation between PvuII (rs2234693), XbaI (rs9340799), and aryl hydrocarbon receptor gene polymorphisms AhR (rs2066853) in breast cancer prognosis. This was a case-control study that included 120 breast cancer patients classified into two groups. The first group included 60 patients with good prognostic factors, and the second group included 60 patients with poor prognostic factors. Blood samples were taken from all study participants to perform the genotyping assay. We found that positive genotypes of PvuII, XbaI, and AhR polymorphisms were strongly associated with better prognostic factors for breast cancer patients, while negative genotypes of PvuII and XbaI were more and significantly prevalent in poor prognostic breast cancer patients. We conclude that PvuII T/C, XbaI G/A, and AhR G/A alleles may be prognostic for breast cancer progression. ‎
Falling between Two Stools : Under Diagnosis of DCD in Childhood and its Implications among Young Adults with Motor Coordination Difficulties
Authors: Zaguri-Vittenberg Shahar , Tal-Saban Miri , Weintraub Naomi
Published: April 2024

Background: Developmental Coordination Disorder (DCD) is prevalent among 6-8% of school-age children, and is defined by major motor-coordination difficulties that significantly and persistently hinder participation in daily activities and quality of life. Evidence suggests that early detection and intervention may improve children with DCDs' daily function and reduce their emotional difficulties. Clinical reports points to possible under diagnosis of DCD. However, the extent of this phenomenon is unknown. The aim of this study was to describe retrospectively the prevalence of receiving DCD diagnosis in a convenience sample of young adults with motor difficulties, as well as to explore their perspectives on receiving a diagnosis. Methods: This mix methods study, included 54 young adults (aged 21-35 years) who met the Diagnostic and Statistical Manual of Mental Disorders 5th edition criteria for DCD were recruited for this study: Percentile < 5 on standardized motor assessment, the Movement Assessment Battery for Children 2nd Edition, report of current and childhood functional-motor difficulties on the Adolescents and Adults Coordination Questionnaire and lack of other neurological conditions such as cerebral palsy. Participants with health conditions other than DCD were excluded. Participants reported on the existence of childhood DCD/Dyspraxia diagnoses and on developmental supports they were received during their childhood. Ten participants were interviewed regarding their perspective on receiving a formal diagnosis. Results: Only three (5.56%) participants were diagnosed with DCD during their childhood. However, 39 (72.22%) received at list one kind of professional support: 22 (40.74%) occupational therapy, 10 (22.73%) physiotherapy, 15 (27.78%) speech therapy, 18 (33.33%) psychotherapy and 10 (22.73%) other complementary treatments. Interviews analysis revealed: (1) childhood included confusion and "otherness", in the absence of an explanation for motor challenges; (2) environmental lack of legitimacy and unawareness of DCD during childhood; and (3) validation and enhanced sense of coherence following a diagnosis. Conclusion: Although identified with difficulties and referred for professional support, adults with DCD were under diagnosed in childhood. As diagnosis can validate 'otherness' experience, under diagnosis can exacerbate stress associated with motor-functional difficulty. To prevent the consequences of future motor difficulties, DCD should be diagnosed in childhood, according to international recommendations.
Comparison of Different Extraction Methods for Bioactive Compounds from Kao-Kum Doi-Saket (Oryza sativa L.)
Authors: Rajchasom Sureewan , Sombatnan Pornsawan , Tancharoenrat Vuthijumnonk Janyawat , Suphiratwanich Phanida
Published: April 2024

Kao-Kum Doi-Saket is one type of purple rice known for its high content of anthocyanin and its ability to resist free radicals. Anthocyanin extracts can be utilized in various applications, including food coloring, nutritional supplements, natural medicine, and cosmetics. There are several methods for extracting anthocyanin from Kao-Kum Doi-Saket. This research aims to compare the effects of extraction methods, including Conventional extraction (CE), Pulse electric field extraction (PEF), and Ultrasonic assisted extraction (UAE) on total anthocyanin content and antioxidant activity in Kao-Kum Doi-Saket. It was found that the UAE method resulted in the highest total anthocyanin content of 57.05 ± 4.27 mg/L, which was significantly different from the other two methods (p<0.05). Kao-Kum Doi-Saket extracts from the UAE method also showed the highest DPPH inhibition (88.32 ± 1.83%) compared to the CE and PEF methods. Therefore, these findings suggest that UAE is the most effective method for extracting anthocyanin and antioxidant activity from Kao-Kum Doi-Saket and could be beneficial for developing processed products from Kao-Kum Doi-Saket in the future.
Exploring the Efficacy of Bacillus oceanisediminis Ba9 from Asian Seabass Cage Sediment in Saline Wastewater Treatment
Authors: Sangnoi Yutthapong , Chankaew Sunipa
Published: April 2024

Preventing toxicity in aquaculture systems from ammonia and nitrite is important. This study isolated the salt-tolerant Bacillus sp. strain Ba9 from bottom sediment under an Asian Seabass (Lates calcarifer) cage cultivating at Koh Yor, Songkhla, Thailand. Morphological characteristics showed that strain Ba9 was rod-shaped, endospore-forming, and Gram-positive. Strain Ba9 grew well at a salinity of 1.5 to 4.0% NaCl. The catalase test of the isolate was positive, while the oxidase test was negative. Based on 16S rRNA gene sequencing data and phylogenetic tree analysis, strain Ba9 was identified as B. oceanisediminis with 97% similarity (strain HQB337T). The result showed that the ammonium removal efficiency of Ba9 in a high ammonium medium was 64.24%. The nitrite and nitrate production were 0.10% and 0.08%, respectively. Consequently, sucrose had been the optimal carbon source for Ba9, which showed ammonium removal was 61.05%. Ammonium sulfate is the most suitable for ammonium oxidation, with 50.53% for the nitrogen source. The optimal C/N ratio of strain Ba9 was 8, with 71.15% ammonia removal. For wastewater improvement, strain Ba9 was inoculated into artificial wastewater for 14 days. The result showed that the ammonium removal efficiency of Ba9 was 96.87%. In addition, the biochemical oxygen demand (BOD) removal efficiency of Ba9 was 90.86%. From this result, the salt-tolerant B. oceanisediminis Ba9 has a high potential as a microbial product for water quality management in marine aquaculture.
Discapacidad y calidad de vida en adultos institucionalizados por consumo de sustancias
Authors: Parra Fauta Daily de los Angeles , Mena Marco Antonio
Published: April 2024

Introducción: El consumo problemático de sustancias constituye uno de los principales problemas de salud pública a nivel mundial, y su impacto es especialmente importante en grupos como los adultos institucionalizados. En este contexto, la discapacidad y la calidad de vida son aspectos relevantes, ya que están ligadas a la salud física y psicológica de estas personas.

Objetivo: Determinar la relación entre discapacidad y calidad de vida en adultos institucionalizados por consumo de sustancias.

Método: Fue de enfoque cuantitativo correlacional y corte transversal, incluyó a 101 adultos varones de 18 a 50 años, institucionalizados en Ecuador.

Resultados: El análisis de correlación fue negativa leve, entre la calidad de vida y dos dimensiones de discapacidad: movilidad y cuidado personal. Sin embargo; no se observó una correlación significativa entre el total de las variables de estudio; además, no existió una diferencia estadísticamente significativa entre los grupos de edad.

Conclusión: El impacto negativo del consumo de sustancias en la calidad de vida de los adultos institucionalizados se refleja de manera significativa en diversos aspectos, como la movilidad y el cuidado personal. Estos individuos enfrentan diariamente desafíos que obstaculizan su desenvolvimiento adecuado, comprometiendo así su bienestar en múltiples dimensiones.
Khảo sát hoạt tính chống oxy hóa và ức chế enzym alpha-glucosidase của Dền gai (Amaranthus spinosus L. Amaranthaceae)
Authors: Lư Bích Ngọc Giàu  , Phan Thiện Vy  , Nguyễn Phương Thanh Ngân  , Phạm Thị Hương Giang
Published: April 2024

Nghiên cứu được thực hiện nhằm làm rõ đặc điểm thực vật và cung cấp thêm thông tinvề hoạt tính hạ đường huyết của Dền gai tại Việt Nam. Dền gai được định danh bằngphương pháp ADN, khảo sát đặc điểm hình thái bằng phương pháp thường quy. Sơ bộhóa thực vật theo phương pháp Ciuley cải tiến bởi Trường Đại học Y Dược Thành phốHồ Chí Minh. Chiết xuất cao toàn phần và 5 cao phân đoạn petroleum ether, chlorofrom, ethyl acetat, n-butanol, nước. Thử hoạt tính chống oxy hóa dựa trên mô hình 2,2- diphenyl-1-picrylhydrazyl (DPPH) và ức chế enzym α-glucosidase trên 6 mẫu cao chiết. Nghiên cứu đã xác định được loài Dền gai (Amaranthus spinosus) bằng phương pháp giải trình tự gen matK, đặc điểm hình thái tương đồng với tài liệu tham khảo. Thànhphần hóa học có chứa chất béo, acid hữu cơ, flavonoid, carotenoid, triterpen, saponin, tanin, chất khử và hợp chất polyuronic. Cao phân đoạn chloroform có hoạt tính chống oxi hóa (IC50 144,97 μg/mL) và ức chế enzym α-glucosidase (IC50 239,25 μg/mL) tốt nhất. Mẫu chứng dương vitamin C (IC50 10,95 μg/mL) và acarbose (IC50 254,03 μg/mL).® 2024 Journal of Science and Technology - NTTU
Phát hiện nhanh Clostridium perfringens bằng kĩ thuật RPA (recombinase polymerase amplification) khuếch đại acid nucleic đẳng nhiệt
Authors: Trần Hồng Diễm  , Lâm Ngọc Ngân Anh
Published: April 2024

Clostridium perfringens được xem là một trong những tác nhân gây ngộ độc thực phẩm phổ biến nhất chỉ sau Salmonella. C. perfringens là trực khuẩn yếm khí, Gram dương có nhiều trong đất, ruột động vật, có thể nhiễm vào các loại thịt, đặc biệt là thực phẩm đông lạnh, gây ngộ độc cho người với các triệu chứng đau bụng và tiêu chảy. Để phát hiện vi khuẩn gây bệnh này, các phương pháp phân lập, nuôi cấy, sinh hóa thông thường cũng như kĩ thuật PCR được thực hiện theo các quy trình phức tạp, tốn nhiều thời gian. Và cũng cần kĩ thuật viên có kinh nghiệm, máy luân nhiệt chuyên dụng đắt tiền. Nghiên cứu này ứng dụng kĩ thuật RPA (recombinase polymerase amplification) khuếch đại acid nucleic đẳng nhiệt để phát hiện nhanh Clostridium perfringens. RPA có thời gian phản ứng nhân bản DNA đích ngắn, thực hiện chỉ tại một nhiệt độ, đạt được độ nhạy và độ đặc hiệu cao. Kết quả đã xác lập được một quy trình phát hiện chính xác đặc trưng của C. perfringens trong thời gian 25 phút tại nhiệt độ 38 0C, nhạy hơn 10 lần so với kĩ thuật PCR, tạo tiền đề cho việc phát hiện trực tiếp C. perfringens trên các loại mẫu thực phẩm.
Mô phỏng sự hấp phụ các hoạt chất thiên nhiên qua da bằng động lực học phân tử
Authors: Đỗ Đình Nhật , Nguyễn Đình Phúc , Triệu Tuấn Anh , Phạm Hoàng Danh
Published: April 2024

Trong những năm gần đây, sự kết hợp giữa mô hình tính toán và thực nghiệm đã trở thành một công cụ hữu ích, đóng vai trò quan trọng trong việc giải thích các mối tương tác sinh học phức tạp ở qui mô phân tử. Bài báo này cung cấp cái nhìn tổng quan về việc ứng dụng phương pháp mô phỏng động lực học phân tử để mô phỏng sự hấp phụ các hoạt chất thiên nhiên trên da, một lĩnh vực đang được quan tâm, liên quan đến các ứng dụng về mĩ phẩm và dược phẩm. Theo đó, bài báo cung cấp các thông tin về việc sử dụng mĩ phẩm, dược phẩm trên da hiện nay; các thông tin về cấu trúc da người, cơ chế xâm nhập của các hoạt chất qua bề mặt da; các phương pháp thực nghiệm để xác định sự xâm nhập các hoạt chất qua da; phương pháp mô phỏng động lực học phân tử và việc ứng dụng phương pháp này để mô phỏng sự hấp phụ các hoạt chất thiên nhiên qua da. Các nghiên cứu về sự hấp phụhoạt chất thiên nhiên qua bề mặt da bằng mô phỏng động lực học phân tử là một lĩnh vực hoàn toàn mới ở Việt Nam.
Đánh giá tác dụng giảm đau của cao chiết từ thân cây Dây khai (Coptosapelta flavescens Korth.) trên chuột nhắt trắng
Authors: Hoàng Thị Phương Liên  , Nguyễn Thị Bạch Tuyết  , Đặng Đại Phúc  , Nguyễn Thị Mộng Quỳnh  , Nguyễn Thị Minh Xuân  , Phạm Trí Nhựt  , Bạch Long Giang
Published: April 2024

Cao chiết xuất từ thân cây Dây khai (gọi tắt là Cao Khai) được dùng để giảm đau, kháng viêm… Nghiên cứu này tiến hành thử nghiệm tác dụng giảm đau ngoại biên của Cao Khai bằng cách tiêm axit acetic 1 % trên phúc mô chuột nhắt trắng, so sánh số lần và thời gian đau quặn của các lô chuột mỗi 5 phút trong vòng 40 phút sau tiêm. Đồng thời tiến hành thử nghiệm tác dụng giảm đau trung ương bằng cách nhúng đuôi chuột vào nước nóng ở (52 ± 0,5) 0C. So sánh tiềm thời giật đuôi tại các thời điểm (60, 90, 120 và 150) phút sau khi dùng thuốc. Thuốc đối chứng trong các thử nghiệm là diclofenac và morphin. Kết quả thống kê cho thấy, Cao Khai 400 mg/kg chưa thể hiện tác dụng giảm đau ngoại biên và giảm đau trung ương (p > 0,05). Cao Khai 800 mg/kg thể hiện tác động giảm đau ngoại biên thông qua việc làm giảm số lần đau quặn trong khoảng thời gian (0 ¸ 30) phút và thời gian đau quặn (0 ¸ 35) phút trong quá trình khảo sát (p < 0,05). Ở thử nghiệm giảm đau trung ương, Cao Khai 800 mg/kg thể hiện tác động làm tăng tiềm thời cảm nhận đau 150 phút (p < 0,05).
Seductions of Writing and Reading
Authors: Draga Alexandru Maria-Sabina
Published: April 2024

A review of Rushdie’s Cross-Pollinations by Dana Bădulescu
GROWTH AND YIELD RESPONSES OF RED AMARANTH TO LOCALLY SOURCED LIQUID MANURE
Authors:   Sher-e-Bangla Agricultural University, Bangladesh, Uddin A.F.M. J. , Jasmine M. M. , Nahid H. M. ,   International University of Business Agriculture and Technology, Bangladesh, Dastagir T. , Husna M. A. ,   Sher-e-Bangla Agricultural University, Bangladesh
Published: April 2024

The experiment was conducted at Horticultural farm, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh during the period of September to November 2023. The experiment was laid out with single factor experiment using a completely randomized design with three replications to study the Growth and Yield responses of Red Amaranth (Amaranthus cruentus L) to liquid manure. The treatments under this study were; T1: Control (Only Water), T2: Vermi Tea; T3: SAU- MLM, T4: SAU-NLM, T5: SAU-PLM. Significant variation of growth and yield parameters were found among the treatments. Among the treatments. The tallest plant (44.3 cm), maximum root length was (13.3cm), maximum leaf area (38.2 sq. cm), maximum leaf number (14.0), maximum fresh weight per plant (22.1g), highest weight of plants per 506.25 sq. cm (274.9 g) and highest yield per ha (54.3 ton) was found in T5 while shortest plant (25.1 cm, minimum root length (4.8cm), minimum leaf area (16.4 sq. cm), minimum leaf number (8.6), minimum weight of plants/506.25 sq.cm. (77.5 g) and the lowest yield per ha (15.6 t) was found in T1 at final harvest (30 days after showing). Considering the overall analysis, it becomes evident that T5 consistently exhibits superior outcomes when compared to the other treatments. The superior performance of T5 suggests that it could be the optimal choice for maximizing agricultural productivity while maintaining a focus on human well-being and environmental sustainability. This treatment option not only results in higher yields, indicating potential economic benefits, but it also contributes to the overall safety and health considerations for individuals involved in the agricultural processes.
India Cannot Afford to Ignore Manufacturing
Authors: Krishna Sridhar
Published: April 2024

Raghuram Rajan and Rohit Lamba are clear that “Acche Din” are not here yet and the direction the NDA government is taking will not get India to the promised land soon. They recommend a strong push for services as against manufacturing, increased spending on education and healthcare, and devolution of power to local governments. They question the logic behind large subsidies to promote manufacturing when the jobs created in this manner are so few.
DTT protein equalization and Tryptophan protein quantification as a powerful tool in analytical proteomics.
Authors: Domingos Inês F. , Carvalho Luís B. , Capelo José L. , Lodeiro Carlos , Santos Hugo M.
Published: April 2024

Assessing total protein levels in biological samples is a common procedure in biochemistry and molecular biology. In this study, we compare tryptophan fluorescence (WF) with Bradford and BCA assays to determine total protein in serum samples. Our results indicate that tryptophan fluorescence spectrometry is an efficient, sensitive, and straightforward technique for quantifying proteins in serum. We observed minimal variation between the three methods: BCA de one with the lowers LOD and LOQ. The tryptophan method offers the possibility of reusing the intact sample that does not need colourimetric reagents for quantification. Consequently, free tryptophan serves as a reliable universal standard. This assay can be performed using a conventional fluorescence spectrometer with cuvettes or in a 96-well plate format with a plate reader. The method was successfully used as proof of concept, using serum from patients diagnosed with myeloma and serum from healthy donors.
Geoprocessamento aplicado em análise de casos graves de Covid-19, na região metropolitana do Vale do Aço, estado de Minas Gerais, Brasil
Authors: Rocha Larissa Cardoso da , Rodrigues Débora Helena Freitas Leite , Assis Thamara de Souza Campos , Barçante Joziana Muniz de Paiva
Published: April 2024

A partir do surgimento dos primeiros casos de COVID-19, viu-se necessidade de estudos para melhor entendimento de seus diferentes cenários. A presente análise teve por objetivo descrever a ocorrência dos casos confirmados graves de COVID-19 na região metropolitana do Vale do Aço, e realizar o geoprocessamento dos casos no município de Ipatinga. Os dados foram coletados por meio do Sistema de Informação da Vigilância Epidemiológica da Gripe, da Secretaria Regional de Saúde de Coronel Fabriciano-MG. Foram utilizados os softwares Google Earth, para o georreferenciamento, e o Quantum GIS (QGIS) versão 3.30, para o processamento das informações. Foram identificados 6.041 casos confirmados graves de COVID-19 na região, entre fevereiro/2020 a julho/2022, com média de idade de 60,6 anos, sendo indivíduos em sua maioria do sexo masculino (54,1%) e pardos (65,2%). O município que registrou o maior número de casos foi o de Ipatinga (55,1%). No período de 2020 a 2021 houve um aumento progressivo dos casos, com redução no ano de 2022. A caracterização de casos associados com o geoprocessamento constitui ferramenta importante para auxiliar nos processos de reconhecimento e priorização das vulnerabilidades sociais, contribuindo com as políticas públicas a serem aplicadas para muitos agravos em saúde, além da COVID-19.
Tendência de sífilis congênita no estado de Roraima
Authors: Teixeira Sabrina Torres , Bertelli Ellen Vanuza Martins , Lima Daniele Moreira de , Santiago Ângelo Rodolfo , Sousa Daniela Trindade de , Silva Cleiry Simone Moreira da
Published: April 2024

Trata-se de um Estudo ecológico de séries temporais, tendo como finalidade analisar todos os casos de Sífilis Congênita (SC) ocorridos nos 15 municípios do estado de Roraima, notificados pelo Sistema Nacional de Agravos de Notificação entre os anos de 2007 a 2020, disponibilizados pelo Departamento de Informática do Sistema Único de Saúde (DATASUS).         O escrito contribuirá significativamente para um melhor entendimento do assunto, de suas causas e determinantes e assim poder auxiliar na elaboração de políticas públicas que visem a obtenção de melhorias na qualidade da assistência pré-natal do estado e possível redução do óbito infantil.
Visions of childhood in The Analogs’s songs
Authors: Gruntkowska Dominika , Szwabowski Oskar
Published: April 2024

In the article we reconstruct the understanding of a child and childhood in the works of The Analogs. Using neoclassical reading and treating the text as the Other, we first show the scenery of childhood. We ask about relationships with adults, and finally, we wonder whether there is a happy childhood in this narrative. Childhood in The Analogs’ songs is presented in grey and is associated with violence and things belonging to the world of adults. There is no sharp boundary between a child and an adult. Childhood is a vestibule of hell to which those born at the wrong time are condemned. Finally, we point out that the vision of childhood in the works of The Analogs does not fit into the dominant discourses about children and poses tasks that can be solved by critical pedagogy.
THE SCIENCE OF POLITICS BY NICCOLO MACHIAVELLI
Authors: Nogueira Pinto Jaime , Szymanek Jarosław
Published: April 2024

The authors present the concept of modern political science proposed by Nicolo Machiavelli. In the authors' opinion, it was around the kingdom and the king, the sovereign state and one ruler that a new political doctrine was born, which took from tradition what could serve it, but was also built on new values, or at least on a new hierarchy of values. Niccolo Machiavelli was the thinker who best combined new, or rather renewed, political values into a coherent modern doctrine of the state and power, which would secularize it and liberate it from the tutelage of religion and morality. The authors point out that the personal experience of life on the divided Athenian Peninsula was crucial for the political thought of the famous thinker from Florence. The authors share the view of Albert Asor Rosa, who tries to find the reasons for this almost paradoxical concentration on the Italian experience of the founder of modern political science, a realistic, calculating, amoral and secularized study of the engines of action of leaders and crowds.This is why the central categories of Machiavelli's political thought are "state interest", "national identity", "raison d'état". The experience of the lack of statehood, on the one hand, and the democratic traditions of the Florentine Republic on the other, created a special amalgam of ideas and views on which a modern understanding of the science of politics was created, which is invariably associated with the name of Machiavelli.
DESBUROCRATIZANDO O ACESSO À JUSTIÇA: UMA AVALIAÇÃO DOS RESULTADOS DO CEJUSC EM CAJAZEIRAS-PB (2013-2022)
Authors: Moraes Éverton Gonçalves , Silva Raul Gonçalves Holanda , Araújo Maria Quitéria Tavares de , Silva Júnior Francisco Paulino da , Alves Davi Dantas , Dutra Wescley Rodrigues , Araújo Daniel Guedes de , Dias Rodolpho Cavalcanti
Published: April 2024

O amplo e efetivo acesso a todos os meios de solução de controvérsias, judiciais ou extrajudiciais, é inerente ao direito fundamental de acesso à justiça. O encargo de promover a jurisdição é constitucionalmente confiado ao Judiciário, que deverá manifestar-se, quando provocado, a solucionar os litígios postos à sua apreciação de forma breve, eficiente e igualitária. Posto isso, questiona-se: a mediação e a conciliação são métodos eficientes para a desburocratização do acesso à justiça? Entendendo que o acesso à justiça se dá a partir da solução da controvérsia, o presente trabalho tem por objetivo analisar se o emprego da mediação e da conciliação no Centro Judiciário de Solução de Conflitos e Cidadania (CESJUSC), que fica situado no Núcleo de Prática Jurídica (NPJ) da Faculdade Católica da Paraíba, na cidade de Cajazeiras-PB, tornaram o acesso mais eficiente. Para isso, lançou-se mãos a análise quantitativa de dados das mediações e conciliações realizadas no período de 2013 a 2022. No contexto da eliminação das barreiras do acesso à justiça, as técnicas de resolução de conflitos, como a mediação e a conciliação surgem como alternativas jurídicas e extrajurídicas viáveis e eficazes também do ponto de vista social.
Local Production of World Health Organization Recommended Hand Rub Formulation and Comparison of its Efficacy with a Commercially Available Alcohol-Based Hand Rub
Authors:   Buddhist mission hospital, Ranchi, Jharkhand, India  Affiliation when study was conducted : Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India, Shagun FNU , Mane Abhijeet K ,   Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India, Kharparde Ashvini ,   Noble Hospital, Pune, Maharashtra, India Affiliation when study was conducted : Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India, Kumar Mahadevan ,   Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India, Tolpadi Anuradha G ,   Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India, Dhayagude Snehal V ,   Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India, Modak Meera S ,   Department of Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, Maharashtra, India
Published: April 2024

Objective: To produce a World Health Organization (WHO)-recommended hand rub formulation locally and compare its efficacy with a commercially available Alcohol-based Hand Rub (ABHR) - Sterillium. Methods: A non-randomized comparative study was conducted. Sixty healthcare workers were divided into two groups - Group A (WHO-recommended hand rub) and Group B (Sterillium). WHO-recommended hand rub was prepared according to the specified formula. Each participant from study Group A received three ml of WHO-recommended hand rub formulation, and each study Group B participant received three ml of Sterillium. Bacterial samples of each participant (from both hands) were collected before and 0 after using an ABHR solution. Samples were inoculated on the nutrient agar plates and incubated at 37 C for 24 hours. The total number of bacterial colonies grown on plates inoculated before and after ABHR use was counted and identified by standard microbiology techniques and compared between the two groups. The WHO-recommended hand rub and Sterillium were compared and analyzed using differences in proportion. Results: The overall reduction in bacterial growth was comparable for both the hand rubs, with an average load reduction of log 1.5607 for locally produced hand rub solution and an average load reduction of log 1.609 in the case of Sterillium. Conclusion: Both of the handrubs are comparable in efficacy and are effective against all the bacteria isolated from the palms of HCWs (Coagulase Negative Staphylococcus (CoNS), Micrococcus spp., Acinetobacter spp., Bacillus spp., Pseudomonas spp., and Citrobacter), including Methicillin-Sensitive Staphylococcus aureus
DEVELOPMENT OF SCIENCE AT A PEDAGOGICAL UNIVERSITY: NEW CHALLENGES AND REALITIES
Authors:   Lugansk State Pedagogical University, Marfina Zh.V. , Roters T.T.
Published: April 2024

The article reviews the main mechanisms for the development of science at Lugansk State Pedagogical University (LSPU) in light of new requirements, challenges, and realities. It determines the vector of scientific and innovative development, analyzes the opportunities of university science at the present stage, and determines the scientific and pedagogical potential.
DETERMINANTS AND VALUES OF FAMILY EDUCATION IN MODERN CONDITIONS
Authors:   Lugansk State Pedagogical University, Turyanskaya O.F.
Published: April 2024

The article examines the problem of values for family education based on the Orthodox tradition, the relevance of which is associated with the modern socio-political and international situation, which determines the actualization of traditional accents in working with families and young people.
CONCEPTUAL APPROACHES O LABOR AND CIVIC EDUCATION OF STUDENTS IN THE PEDAGOGICAL LEGACY OF GEORG KERSCHENSTEINER
Authors:   Lugansk State Pedagogical University, Pilavov P.A.
Published: April 2024

The article analyzes pedagogical literature on the problems of labor and civic education of the younger generation in historical retrospect. It pays particular attention to the theoretical developments and practical implementation of the ideas of the «labor school» of the German scientist G. Kerschensteiner. It concludes that it was G. Kerschensteiner who proposed a model of a school in which children of the commons could gain the necessary work experience for their prospective profession by mastering a certain amount of theoretical knowledge.
PEDAGOGICAL OPPORTUNITIES FOR THE DEVELOPMENT OF READING LITERACY IN A SCHOOL SOCIAL SCIENCE COURSE
Authors:   Moscow City University, Basik N.Y. , Kupalov G.S.
Published: April 2024

The formation of reading literacy is an important component of the school’s social studies course, as it promotes the development of critical thinking skills, information analysis, self-study of sources, and also allows you to get a broad overview of knowledge about social processes and phenomena. In today’s information-rich world, the ability to analyze and understand texts is becoming increasingly important. Reading literacy allows students to consciously work with texts, identify their main idea, arguments and evidence, and evaluate the reliability and reliability of in- formation. It also helps students distinguish facts from opinions, recognize rhetorical techniques and logical errors in the text. Through the study of texts of a social science orientation, students learn about various social problems, political and cultural phenomena, as well as about the historical and modern development of society. This helps them develop analytical thinking and form their own position on various social issues. The article presents options for tasks when working with various types of text in a school social studies course: scientific and popular science texts, normative texts.
THE NEET GENERATION AND THE DEVELOPMENT OF NATIONAL EDUCATION SYSTEMS
Authors:   Moscow City University, Niderman I.A. , Shener M.V.
Published: April 2024

The article presents an analysis of the problem of the NEET generation of youth, identifies the main reasons for the emergence of this phenomenon, and determines the relationship of this phenomenon with the development of national education system.
CONDITIONS CONTRIBUTING TO THE PROFESSIONALIZATION OF PEOPLE WITH DISABILITIES AND/OR LIMITED HEALTH CAPABILITIES
Authors:   Pedagogical Innovation and Inclusive Education  of Kazan Innovation University named after V.G. Timiryasov, Akhmetova D.Z. , Makarova T.Yu. ,   Institute of Biotechnology and Global Health
Published: April 2024

The article was prepared as part of the State Assignment for the provision of public services (performance of work) under Project FSMF-2023-0008 «Forming Motivation among Students with Disabilities and Limited Health Capa- bilities to Master the Profession of “Technologist” in the Higher Education System». The authors studied the prob- lem of professional development of people with disabilities and limited health capabilities (LHC) at the stages of obtaining a profession, including through their participation in the international non-profit movement «Abilimpix». The article makes conclusions that will contribute to this process.
Prevention of pneumonia associated with invasive mechanical ventilation in an intensive care unit
Authors: Vaca Moreno Andrea Pamela , Quinteros Portilla Rocío Elizabeth , Paredes Garcés Mónica Guadalupe , Acosta Jeannette
Published: April 2024

Introduction: ventilator-associated pneumonia represents between 30 % and 70 % of morbidity and mortality rates; its incidence is reflected in increased hospital stay and health care costs for health care institutions. Objective: to determine the nursing care to be applied in adult patients for the prevention of ventilator-associated pneumonia in Intensive Care Units. Methods: the study was carried out by means of a research strategy applied in the search engines and databases Google Scholar, Pubmed, Lilacs, SciELO, Cochrane, CINAHL. After the search, 143040 records were identified; 86 articles that met the search criteria: Healthcare - Associated Pneumoniae, Respiration Artificial associated with nursing care; and inclusion criteria were annexed to the study. Results: the following main activities focused on the prevention of ventilator-associated pneumonia were determined: Strict hand hygiene with alcohol-based products (ABP) before handling the airway. Control and maintenance of pneumotap pressure (> 20 cm H2O). Avoid supine decubitus at 0°, whenever possible. Aspiration of subglottic secretions. Promote the process of early weaning, in a safe manner. Oral hygiene with chlorhexidine (0,12 – 0,2 %). Conclusions: nursing activities decrease the incidence of pneumonia in mechanical ventilation. Continuous training should be promoted in order to provide care validated under scientific evidence
Conflict Management Strategies in Human Resources Management Work Teams
Authors: Rismayadi Budi
Published: April 2024

This research aims to investigate effective conflict management strategies in the context of human resource management (HR) work teams. Conflict in the workplace, especially in HR teams, can be a significant challenge that affects productivity and harmony among team members. This research uses a qualitative approach with descriptive methods. The research results show that the implementation of conflict management strategies in human resource management work teams has a significant positive impact in improving harmonious and productive working relationships in the workplace. By implementing an open communication approach, teams can easily share information, express opinions, and resolve conflicts more effectively. Collaborative conflict resolution also allows team members to work together to find a solution that is satisfactory for all parties involved, thereby reducing the possibility of larger conflicts arising in the future. Additionally, through developing communication skills, team members can improve their ability to listen, express thoughts clearly, and understand others' perspectives, all of which are important aspects of managing conflict wisely.
Research of the vacuum low-temperature frying process Pleurotus eryngii
Authors: Bolhova Nataliia , Fang Lin , Nazarenko Yuliya , Synenko Tetiana
Published: April 2024

Mushrooms are consumed because of their nutrients and therapeutic bioactive compounds, historically used in medicine, and representatives of the genus Pleurotus are edible species rich in dietary fibre, vitamins, micro- and macroelements, and carbohydrates. The aim is to theoretically substantiate the vacuum frying of oyster mushroom pieces and to obtain a crispy product with optimal consumer characteristics. In the course of the study, the methods of vacuum low-temperature frying, organoleptic study, orthogonal test, single-factor and statistical analysis were used. The factors affecting the quality of vacuum roasting of oyster mushrooms: pre-drying time, temperature and roasting time are analysed. The relationship between oil content and sensory evaluation is described and analysed. The optimal technological parameters of vacuum frying were determined. Pleurotus eryngii with a thickness of 2 mm were completely inactivated under boiling conditions for 90 s at 80℃, and for 10 s at 90 and 100℃. If prolonged cooking takes place, the oyster mushroom texture becomes soft and is not amenable to further processing under vacuum at low temperature. Therefore, in order to save production energy and reduce the loss of flavour and nutrients, cooking at 80°C for 90 s was chosen. It has been shown that the treatment of Pleurotus eryngii with maltodextrin before vacuum frying reduces the oil content after frying, provides a homogeneous structure, good taste and crispiness of the product. Optimal parameters were obtained: 2 mm slices, mass fraction of maltodextrin 15%, sonication duration 15 min. The influence on the sensory evaluation of the primary and secondary order is described: frying temperature > pre-drying time > frying time. The specific parameters for which the product will obtain the best sensory characteristics were indicated, namely: frying for 10 min, pre-drying for 20 min, frying temperature of 90℃. The factors influencing the oil content were analysed: pre-drying time > frying time > frying temperature. It was found that the product can obtain the lowest oil content when pre-drying for 30 minutes and frying at 80°C for 10 minutes. The practical value of the study lies in the optimal conditions of the process under investigation: pre-drying time with hot air 20 min, frying temperature 80-90°C, frying time 10 min, frying vacuum 0.08-0.09 MPa
Synergic Effects of Carica papaya Leaves and Fermented Fish Waste on Growth Performance, Carcass Yields, Sensory Attributes, and Profitability in Broiler Production
Authors: Ramoso Rhea F. , Ramoso Jr. Gilmore M. , Cordova Siony M. , Rabadan Ever Joy G.
Published: April 2024

Poultry production sustainability requires innovative dietary supplements to improve performance while addressing environmental concerns. This research investigates the effects of supplementing broiler chicken diets with Carica papaya leaf meal (CPL) and fermented fish waste (FFW) in water on various growth parameters, carcass traits, sensory attributes, and profitability. A Randomized Complete Block Design (RCBD) with a 2x4 factorial arrangement was employed, evaluating two factors: CPL dietary supplementation at 10% and FFW water supplementation at 0%, 5%, 10%, and 15%. Each treatment combination was replicated four times with five broiler chicks per replication, totaling 160-day-old broilers. Results indicated that while CPL negatively influenced final body weight and weight gain, FFW positively impacted feed intake, final weight, and weight gain. Additionally, FFW supplementation led to significant increases in drumstick and thigh weights compared to the control, with notable interactions observed between CPL and FFW for breast, wing, and back weights. However, neither CPL nor FFW affected the weights of edible visceral organs. Sensory evaluation revealed no significant differences in meat quality attributes across treatments. Despite increased production costs, supplementation with CPL and FFW resulted in higher dressed weights and profitability, with the highest return on investment achieved by broilers receiving the standard diet plus 15% FFW supplementation. These findings suggest that optimized utilization of CPL and FFW at 10% and 15% respectively, presents an economically viable strategy for enhancing broiler growth, carcass quality, and profitability while leveraging nutritional benefits and reducing environmental waste.
Tiempo al acceso al tratamiento dirigido en cáncer de pulmón de células no pequeñas no escamoso metastásico
Authors: Freile Berenice , Coria Maria Cecilia , Vargas Gisela , Enrico Diego , Peralta Tanco Delfina , Tsou Florencia , Pombo Teresa , Mendoza Andrea , Salanova Ruben , Waisberg Federico , Chacón Matías , Puparelli Carmen , Martin Claudio
Published: April 2024

El descubrimiento de alteraciones moleculares accionables y su tratamiento dirigido ha mejorado el pronóstico del CPNCP metastásico (1). El acceso al testeo y al tratamiento dirigido representa una limitación en nuestro país. En este estudio retrospectivo, el objetivo es describir el tiempo a la demora entre la solicitud del testeo molecular y el inicio de tratamiento dirigido en CPNCP metastásico no escamoso con mutación accionable en primera línea. Se incluyeron pacientes entre 01/2018 y 10/2022, con registro de fecha exacta de inicio de tratamiento. Se consideran dos cohortes, según el tipo de testeo utilizado, el molecular individual o el panel multigenético. Entre los 437 pacientes que fueron testeados, 76.2% utilizaron testeo molecular individual y 23.79% panel multigenético. Entre los pacientes con testeo individual, el 22.2% tuvo mutación accionable. Entre los que accedieron al tratamiento dirigido, la mediana de demora al inicio tras la solicitud del testeo molecular fue de 22 días (RIC: 15.5-30.5). En cuanto a los que se realizaron panel multigenético, en el 57.7% se detectó una mutación accionable, la mediana de días de inicio del tratamiento tras la solicitud del testeo fue de 36.5 días (RIC: 30-51). Considerando ambas cohortes, hay acceso de aproximadamente el 60% al tratamiento dirigido en primera línea. Una vez identificada la mutación la cobertura no genera una demora mayor para la aprobación del tratamiento.
The Analysis of the Problems Faced by The Teachers in Education Sector in Developing English Writing Skills: An investigation of District Hyderabad, Sindh
Authors: Lakhan Rafique Ahmed , Bhatti Amina Bibi , Kolachi Habibullah
Published: April 2024

Although Sindh's education system is beset with difficulties, this study examines how to teach English writing skills, which can require helping students gain the language and communication confidence they need—a difficult concept to grasp. Numerous variables might influence the process of imparting knowledge and developing abilities. The majority of public sector institute students struggle with English writing and eventually receive subpar education. The main goal of Sister Day is to draw attention to the challenges faced by educators in helping students enhance their English writing abilities. The primary focus of the research is the Hyderabad district's Sector Institute. These institutions produce samples from both rural and urban locations.
Ecocriticism: From Conversation to Conservation
Authors: Dr. Arun Kumar Yadav
Published: April 2024

In an era defined by mounting environmental crises and an expanding awareness of the urgent imperative for sustainability, ecocriticism has emerged as a pivotal discourse uniting literature, culture, and environmental advocacy. This research paper investigates the ever-evolving terrain of ecocriticism, charting its evolution from its origins as a conversational and theoretical movement to its current status as a driving force behind conservation efforts. By examining the dynamic interplay between literature, culture, and the environment, this paper delves into the evolution of ecocriticism over time and its significant role in promoting ecological awareness and spurring action. It provides a thorough analysis of the historical progression of ecocriticism, tracing its origins in literary criticism and its expansion into a multidisciplinary approach encompassing various media and cultural forms. The paper discusses the key theoretical frameworks that have shaped the field and highlights the contributions of influential eccritics.

Moreover, this research emphasizes the practical applications of ecocriticism in furthering environmental conservation efforts. It explores case studies and real-world examples where ecocriticism has played a central role in raising environmental consciousness and promoting sustainable practices. The paper argues that ecocriticism has moved beyond theoretical discourse to become a potent force in safeguarding the planet, illustrating how literature and culture can effectively address the urgent environmental challenges of our era.
Security in cloud computing: Methods for ensuring privacy and integration in modern applications
Authors: Zarichuk Oleksii
Published: April 2024

Cloud computing has become a necessary component for data storage and processing and is becoming more widespread. However, there are threats to the security and privacy of user data, which is why it is important to find out the most effective methods for ensuring data security in the cloud. The purpose of the study was to develop methods aimed at ensuring privacy and security in cloud environments and in modern applications. The method of analysis was used to review other publications on the topic, and the method of experiment was used for practical implementation. The main results of the study include the development of a security monitoring programme. It analyses event logs and determines the number of failed login attempts, which indicates the detection or absence of suspicious activity. Access to resources is checked, and the necessary information is displayed on the console. A comparison table of cloud platforms has been created, considering their advantages and disadvantages in the context of data security and privacy. It specifies the criteria for delivering services to the selected services. A block diagram of ways to provide security in cloud computing is developed, illustrating the relationship between various aspects of providing security in cloud systems. It contains parameters and strategies for encrypting data, protecting sensitive data, and countering attacks. Various aspects of security and methods of ensuring privacy in cloud computing are considered, namely authorisation, intrusion detection, regulatory requirements, integration with modern applications, monitoring and logging, user identification and authentication. The practical significance of the study lies in the creation of innovative ways to help improve security and privacy in cloud computing. They will allow cloud developers and administrators to effectively protect user data and ensure their privacy in modern applications
Schüler:innen mit einer Hörbeeinträchtigung im teilintegrativen Bildungssetting
Authors: Girard-Groeber Simone
Published: April 2024

Der Beitrag basiert auf einer Studie, in welcher die Partizipation von vier Jugendlichen mit einer Hörbeeinträchtigung in einem teilintegrativen Setting beobachtet wurde. Untersucht wurden typische Interaktionsformen von Jugendlichen mit einer Hörbeeinträchtigung, die in deutscher Lautsprache und in Deutschschweizerischer Gebärdensprache kommunizieren und mit Unterstützung einer hörenden Assistenzperson am Unterricht teilnehmen. Die Ergebnisse zeigen die zentrale Rolle der Assistenzperson sowie Herausforderungen und Grenzen der Unterstützung. Abschliessend wird auf mögliche erweiterte Unterstützungsleistungen hingewiesen, insbesondere durch fliessend gebärdende Assistenzpersonen und Dolmetscher:innen mit erweitertem Auftrag.