bluuebunny/crossref_metadata_2025 huggingface dataset:
Uma resposta aos novos paradigmas, novos desafios intermidiáticos e multimodais: A Crítica Genética Inclusiva
Authors: Anastácio Sílvia Guerra
Published: April 2024

Os estudos dos processos de criação têm se desenvolvido especialmente a partir do século passado, enriquecidos pelos avanços tecnológicos e pelo surgimento de novos paradigmas a serem seguidos. Tem-se, então, o leitor imersivo do cyberespaço, que navega pelo ambiente virtual onde circulam textos multimidiáticos e multimodais (ELLESTRÖM, 2010), um espaço promissor para dar acesso a produtos artísticos diversos via rede (SANTAELLA, 2016). É nesse contexto virtual que navega o cyber leitor, que se beneficia com os processos de traduções e compartilhamento de saberes diversos; assim, ele tem acesso à arte, em particular à literatura, inclusive, os que possuem alguma deficiência auditiva, visual, intelectual ou de outra ordem. Assim, a questão da inclusão dá o tom a uma Crítica Genética Inclusiva, que se justifica pelo desafio de atender a políticas sociais relevantes para a sociedade, hoje. Como os índices desses processos vão sendo armazenados, ao longo do percurso, e dialogam entre si como uma trama semiótica significativa (PARENTE, 2004; SALLES, 2008), constituindo ricos dossiês genéticos digitais (BIASI, 2010; CRASSON, 2014) são questões que merecem análises cuidadosas. Neste artigo, daremos visibilidade às modalidades de Crítica Genética Inclusiva que têm sido praticadas por geneticistas, com um foco particular para a construção de audiolivros.
Uma semana Carolina: mostras do manuscrito autógrafo número 11
Authors: Silva Milena Paixão
Published: April 2024

No equilíbrio entre garantir o alimento diário para o corpo e para a alma, enquanto morou no Canindé, Carolina Maria de Jesus registrou em cadernos reaproveitados o cotidiano que a cercava. Esses escritos fazem parte de duas obras publicadas pela Editora Francisco Alves, Quarto de Despejo: diário de uma favelada (1960) e Casa de Alvenaria: diário de uma ex-favelada (1961). Diante de uma produção vastíssima, que passeia por poesia, contos, romances, peças teatrais, canções etc., e que muito ainda carece de estudos e publicação, nos interessa pensar, neste trabalho, o quanto de Carolina podemos vislumbrar através da leitura de um recorte de seus registros, compreendido por uma semana de entradas de diário correspondente ao manuscrito do caderno de número 11, que faz parte da publicação de sua primeira obra. A proposta, então, é conhecer Carolina pela escrita de Carolina, sem o intermédio dos processos de edição. Sob a ótica da Crítica Genética, que desloca a interrogação crítica da autoria para o/a escritor/a, do escrito para escritura, da estrutura para o processo e da obra para a gênese, questiona-se: o que as páginas autógrafas do caderno de número 11 de Carolina Maria de Jesus nos revelam sobre Carolina Maria de Jesus?
Gustave Flaubert e Maxime Du Camp: diferentes concepções de obra literária
Authors: Ribeiro Lúcia Amaral de Oliveira
Published: April 2024

In this article, I discuss questions about the differences between Gustave Flaubert and Maxime Du Camp relating to each one's style, projects and the way they insert themselves in the literary camp in the last half of 19th century.
Revista Genesis n.46 Entre les langues
Authors: Souza Rubia
Published: April 2024

Resenha da revista Genesis n° 46 “Entre les langues”, artigos selecionados e apresentados por Olga Anokhina e Emilio Sciarrino, ITEM/CNRS, Paris: Presses de l’Université Paris-Sorbonne (PUPS), 2018. Genesis é uma revista internacional do Institut des Textes et Manuscrits Modernes (ITEM) que publica, desde 1992, pesquisas em Crítica Genética. Para a edição de número 46, intitulada “Entre les langues” e lançada em junho de 2018, os seus organizadores Olga Anokhina, linguísta, pesquisadora e coordenadora da equipe Multilinguisme, création et traduction do ITEM e Emilio Sciarrino, professor na Universidade de Amiens, também membro da mesma equipe e pesquisador em estudos italianos plurilíngues, realizaram uma criteriosa seleção dos mais recentes estudos em plurilinguismo literário sob à luz da Crítica Genética.
Duas cavalgaduras: o processo criativo como objeto da ficção
Authors: Martins Milena Ribeiro
Published: April 2024

Análise do conto “Duas cavalgaduras”, de Monteiro Lobato, publicado pela primeira vez na Revista do Brasil, em 1923, e no mesmo ano inserido na coletânea O macaco que se fez homem, quarto e último livro de contos do escritor. Trata-se de um conto singular na sua produção, devido a uma soma de elementos que lhe são estruturantes: o recurso intensivo à metalinguagem, a inserção de proposições teóricas sobre a produção e a recepção da literatura, a retomada e a discussão da tradição por meio da intertextualidade, a sugestão de relações pessoais no sistema literário brasileiro dos anos 1920. Além disso, a análise debruça-se também sobre o processo de escrita do conto, por meio da comparação de duas de suas variantes. Enquanto outros contos sofreram pequenas modificações depois da publicação em periódico, este foi dos mais intensamente modificados num curto espaço de tempo.
Estudos de tradução genética: uma disciplina emergente
Authors: Cordingley Anthony , Montini Chiara , Terenzi Juan Manuel
Published: April 2024

Este artigo mapeia o surgimento de uma nova forma de pesquisa tradutória que nós chamamos de estudos genéticos de tradução. Ela explora as bases desta abordagem na escola francesa da critique génétique que desenvolveu uma metodologia para estudar os rascunhos, manuscritos e outros documentos de trabalho (avant-textes) de obras literárias modernas, com o objetivo de revelar a complexidade dos processos criativos envolvidos em sua produção. Esta metodologia se baseia em diferentes abordagens teóricas e interdisciplinares (poética, linguística, filosófica, psicanalítica, fenomenológica, etc.) e desde então foi adaptada para o estudo de outras mídias, incluindo música, cinema, fotografia, pintura, arquitetura, e o texto traduzido. Este artigo analisa como as abordagens genéticas foram aplicadas aos textos traduzidos tanto por críticos genéticos como por estudiosos da tradução. Além disso, se destacam as oportunidades, bem como os desafios, para a pesquisa de tradução literária – ou de outras formas – quando uma abordagem genética é adotada.
The Consequence of Velocity Ratio and Curvature of the Surface on MHD Forced Convection Boundary Layer Nanofluid Flow Over an Axisymmetric Cylindrical Surface
Authors: Hani Umme , Ali Mohammad , Alam Mohammad Shah
Published: April 2024

The present study has considered the steady laminar incompressible non-Newtonian fluid over an axisymmetric stretching cylindrical surface under the effect of the curvature parameter, Brownian motion parameter, and thermophoresis parameter within the boundary layer region. The main
goal of this study is to investigate the numerical analysis of nanofluid flow within the boundary layer region with the effects of the curvature parameter and velocity ratio parameter. The novelty of this paper is to propose a numerical method for solving thirdorder ordinary differential equations
that include both linear and nonlinear terms. The governing equations have been converted into ordinary differential equations (ODEs) by using appropriate transformations. Runge–Kutta’s fourth-order method is used to find the numerical solutions by exploiting symbolic software
MATLAB via the shooting method. It is found that the temperature profile increases for the effect of the thermophoresis parameter and heat generation parameter while decreasing for the effect of the curvature parameter. This study makes an essential contribution to the nanofluids field to
solve numerically nonlinear differential equations (DEs). Brownian motion and thermophoresis parameters are considered for the nanofluid effect which plays an important role in the variation of temperature and concentration.
Unsteady Power Law Nanofluid Flow Subjected to Electro-Magnetohydrodynamics with Active and Passive Nanoparticles Flux
Authors: Chandel Shikha , Sood Shilpa , Sharma Sonika , Prasad Sushil
Published: April 2024

The heat and mass transfer characteristics of power-law nanofluid flow over a stretching sheet embedded in a porous medium with active and passive control of wall mass fluxes are explored in this research. Additionally, the formulation incorporates electromagnetohydrodynamic (EMHD),
Brownian movement, and thermophoresis aspects in the flow problem. The solutions of formulated boundary layer fluid flow equations are represented via tabular and graphical demonstrations to study the impact of the leading parameters. MATLAB inbuilt bvp4c solver is utilized for numerical simulation
of presented fluid flow theories. Physical elaboration of the graphs is given to recognize the influence of fluid flow, heat, and mass transport mechanisms in different rising conditions. Results show that the implication of magnetic field, unsteadiness, and porous medium restricts the fluid
flow velocity while the electric field enhances it. Active control of nanoparticles dominates the velocity, temperature, and concentration profiles more than passively controlled conditions. The significance of the power-law index enclosed in the current study shows that the performance of
pseudoplastic fluids (n < 1) is improved than that of dilatant fluids (n > 1).
Effect of Three Types of Magnetic-Field Modulation and Different Shapes of Nanoparticles on the Instability of Nanofluid (Al2O3 + H2O) Saturated Porous Medium with Internal Heating
Authors: Ismail  , Bhadauria B. S. , Kumar Awanish , Srivastava Anurag
Published: April 2024

In this article the authors investigate the effect of three different types of magnetic-field modulation namely triangular-wave form, sine-wave form, and square-wave form on the instability of nanofluid (Al2O3 + H2O) saturated porous medium with internal
heating. Linear stability analysis is done analytically using the normal mode approach, whereas nonlinear stability analysis is done by using the truncated Fourier series method. We obtained that the internal heating parameter destabilizes the system, whereas Darcy number and magnetic Chandrasekhar
number stabilizes the system. The impact of three different shapes (Sphere/Bricks/Cylinder) of nanoparticles over instability is also analyzed, and it is found that the system is most stable for sphericalshaped nanoparticles while least stable for cylindrical-shaped nanoparticles. Mass/heat
transfer in the system is analyzed by two different approaches, Mathematica NDSolve and Runge-Kutta-Fehlberg method (RKF-45), and it is found that the rate of mass/heat transfer is exactly the same in both cases. The internal heating and magnetic Chandrasekhar number play a crucial role in
the heat/mass transfer in the system. Moreover, it is also noticed that heat and mass transfer start earliest in the case of triangle-waveforms as compared to other types of magnetic-field modulations.
Effect of Magnetic Field on the Instability of Jeffrey Nanofluid (CuO + Blood and Cu + Blood) Filled in Hele-Shaw Cell with Rotation
Authors: Kumar Awanish , Bhadauria B. S.
Published: April 2024

There are so many works present in the literature with Hele-Shaw cell, Jeffrey nanofluid, magnetic field, and rotation individually, but here we carried out the combined study of these and it is important because there are so many applications of these in engineering, it may be used
in energy absorption in the solar panel, because of Hele-Shaw cell is approximately similar to the solar panel. The main goal of the article is to analyse the instability of Jeffrey nanofluid filled in Hele-Shaw cell in the presence of the magnetic field and rotation. During the investigation,
we obtained that the rotation parameter directly affects the behaviour of the Hele-Shaw number and magnetic Chandrasekhar number. Here we also analyze the behaviour of two different types of nanofluids (CuO + Blood and Cu + Blood) on the onset of convection and found that the onset of convection
gets delayed in (Cu + Blood). Heat/mass transfer in the system has been analyzed by Mathematica NDSolve and Runge-Kutta-Fehlberg method (RKF-45) and found that the rate of heat/mass transfer is exactly the same by both methods. The Taylor number directly affects the behaviour of heat transfer
and also found that the onset of convection gets advanced in Jeffrey fluid.
Effects of Pressure Gradient on Fluid Flow and Energy Distribution in a Bending Square Channel
Authors: Mondal Rabindra Nath , Adhikari Sreedham Chandra , Chanda Ratan Kumar , Ghalambaz Mohammad , Islam Mohammad S.
Published: April 2024

A precise knowledge on fluid flow and energy distribution in a bending channel is important for the thermal management of various engineering problems. The literature currently lacks a comprehensive understanding on how fluid characteristics and heat transfer in a bending channel are
affected by pressure gradients, as well as when and how fluids transit into a turbulent state under continuous pressure gradient. The present study aims to explore the bifurcation structure of the steady solutions, linear stability and velocity distribution of the solutions and the transitional
behavior from stead-state to other flow states (i.e., periodic or chaotic) for an extensive domain of the Dean number 0 < Dn ≤ 5000. The geometry of the problem is that the outer and bottom walls are heated while the inner and top are at room temperature. A proper grid analysis
and validation are performed as well. The study successfully analyzed four branches of steady solutions where stability exists only in the first branch up to Dn = 2593.3709 and 2- to 7-vortex solutions are observed in the secondary flow. The flow transitions in the unsteady solutions
are analyzed exquisitely by performing time-advancement of the solutions followed by inquisition of the phase space of time-dependent solutions. Results show that, if Dn > 2593.3709, the steady-state flow becomes periodic followed by a chaotic solution and 2- to 5-vortex solutions
are observed for the unsteady flow. It is noticed that, if Dn > 0, the value of the Nusselt number (Nu) was initially higher on the cooling wall compared to the heated wall and at Dn = 102.67, Nu is found to be equal on both sidewalls and then it started increasing
rapidly on the heated walls. The present study figured out how centrifugal force impacts fluid flow for larger pressure gradient, which assists fluid mixing and consequently enhances heat transfer in the fluid.
Natural Convection and Entropy Generation in a Nanofluid Filled Cavity with a Hanged Fin and Heated from the Bottom
Authors: Bouchouc A. M. , Mebarek-Oudina F. , Azizi M. W. , Sankar M.
Published: April 2024

This paper investigates the Entropy Generation (EG) due to buoyant nanofluid convective flow in a square geometry with a fin. Top wall of the closed space is retained with cold thermal condition (TC), the lower boundary is preserved at a higher temperature (TH),
and adiabatic constraints are imposed on the rest of the region, fin is treated as conductive. The model equations are discretized from the finite volume method via a homemade computer code. The study is executed for a vast ranges of Rayleigh number (104 ≤ Ra ≤ 105),
nanoparticle concentration (0 ≤ φ ≤ 0.1), location of the fin (h*), thermal conductivity (K), and length of the fin. The impacts of Ra, solid volume fraction, fin size and position, on EG and heat transport (HT) rate have been investigated. The outcomes
have shown that the optimal placement of the fin at C* = 0.75 suggests that there is a specific position where the fin creates the most efficient heat transfer, while the minimum Nusselt number at h* = 0.25 indicates that this placement is the least effective
for HT. An enhancement in the global Nusselt number was found with the nanoparticle concentrations. Heat transfer could also be improved with an enhancement of the fin length and EG reduces with the increment in the nanoparticle concentration. Finally, it was observed that the heat dissipation
rate is enhanced with the nanoparticle concentration.
The Zonal Seasonal Cycle of Tropical Precipitation: Introducing the Indo-Pacific Monsoonal Mode
Authors: Tuckman P. J. , Smyth Jane , Lutsko Nicholas J. , Marshall John
Published: April 2024

The intertropical convergence zone (ITCZ) is associated with a zonal band of strong precipitation that migrates meridionally over the seasonal cycle. Tropical precipitation also migrates zonally, such as from the South Asian monsoon in Northern Hemisphere summer (JJA) to the precipitation maximum of the west Pacific in Northern Hemisphere winter (DJF). To explore this zonal movement in the Indo-Pacific sector, we analyze the seasonal cycle of tropical precipitation using a 2D energetic framework and study idealized atmosphere–ocean simulations with and without ocean dynamics. In the observed seasonal cycle, an atmospheric energy and precipitation anomaly forms over South Asia in northern spring and summer due to heating over land. It is then advected eastward into the west Pacific in northern autumn and remains there due to interactions with the Pacific cold tongue and equatorial easterlies. We interpret this phenomenon as a “monsoonal mode,” a zonally propagating moist energy anomaly of continental and seasonal scale. To understand the behavior of the monsoonal mode, we develop and explore an analytical model in which the monsoonal mode is advected by low-level winds, is sustained by interaction with the ocean, and decays due to the free tropospheric mixing of energy.

Significance Statement

Regional concentrations of tropical precipitation, such as the South Asian monsoon, provide water to billions of people. These features have strong seasonal cycles that have typically been framed in terms of meridional shifts of precipitation following the sun’s movement. Here, we study zonal shifts of tropical precipitation over the seasonal cycle in observations and idealized simulations. We find that land–ocean contrasts trigger a monsoon with concentrated precipitation over Asia in northern summer and near-surface eastward winds carry this precipitation into the west Pacific during northern autumn in what we call a “monsoonal mode.” This concentrated precipitation remains over the west Pacific during northern winter, as further migration is impeded by the cold sea surface temperatures (SSTs) and easterly winds of the east Pacific.
The Improvement of Short-Term Quantitative Precipitation Forecast in Mountainous Areas by the Assimilation of Meteorological State Variables Retrieved by Multiple Doppler Radar Data
Authors: Liou Yu-Chieng , Chou Tzu-Jui , Cheng Yu-Ting , Teng Yung-Lin
Published: April 2024

This study presents a sequential procedure formulated by combining a multiple-Doppler radar wind synthesis technique with a thermodynamic retrieval method, which can be applied to retrieve the three-dimensional wind, pressure, temperature, rainwater mixing ratio, and moisture over complex terrain. The retrieved meteorological state variables are utilized to reinitialize a high-resolution numerical model, which then carries out time integration using four different microphysical (MP) schemes, including the Goddard Cumulus Ensemble (GCE), Morrison (MOR), WRF single-moment 6-class (WSM6), and WRF double-moment 6-class (WDM6) schemes. It is found that through this procedure, the short-term quantitative precipitation forecast (QPF) skill of a numerical model over mountainous areas can be significantly improved up to 6 h. The moisture field plays a crucial role in producing the correct rainfall forecast. Since no specific microphysical scheme outperforms the others, a combination of various rainfall scenarios forecasted by different MP schemes is suggested in order to provide a stable and reliable rainfall forecast. This work also demonstrates that, with the proposed approach, radar data from only two volume scans are sufficient to improve the rainfall forecasts. This is because the unobserved meteorological state variables are instantaneously retrieved and directly used to reinitialize the model, thereby the model spinup time can be effectively shortened.
Improvement of point of care testing device for accurate whole blood glucose measurement in early neonates
Authors: Koyano Kosuke , Arioka Makoto , Nakao Yasuhiro , Morimoto Aya , Sugino Masashiro , Morita Hirosuke , Nakamura Shinji , Kondo Sonoko , Konishi Yukihiko , Yasuda Saneyuki , Kusaka Takashi
Published: April 2024

Background

It is important that blood glucose concentrations be accurately and conveniently measured in infants. However, especially in the early neonatal period, point-of-care testing devices used for adults may not accurately measure blood glucose concentrations in neonates.

Methods

In Study 1, the accuracy of neonatal whole-blood glucose measurements was evaluated for the existing glucose analyser Glutest Mint® (hereinafter MINT1; Sanwa Kagaku Kenkyusho, Nagoya, Japan) by comparing the data with reference blood glucose concentrations. In Study 2, we used MINT2, which was modified based on the findings from Study 1, to measure whole-blood glucose concentrations in newborns, and the accuracy of the measurements was compared with that of MINT1.

Results

Blood glucose concentrations were measured in 100 infants each in Study 1 and 2. In Study 1, the whole-blood glucose concentrations measured using MINT1 were found to be significantly lower than the reference blood glucose concentrations in early neonates. The results of Study 1 suggested that characteristics of erythrocyte membranes in early neonates affected the measurements. Therefore, we conducted Study 2 using MINT2, which was modified to be less susceptible. MINT2 was found to accurately measure whole-blood glucose concentrations in the early neonatal period.

Conclusion

The study showed that the point-of-care testing device could be improved to allow for accurate whole-blood glucose measurements in the early neonatal period.
A nostalgic trip? Klaus Rifbjerg’s “På Sporet af den Tabte Vogn” and the Copenhagen tramway
Authors: Borch Adam
Published: April 2024

For much of the twentieth century, the tramway was the most important public transport system in Copenhagen, Denmark. It played a crucial role in the life of the city and features strongly in Danish art and literature produced during the network's lifespan as well as after it was finally closed in 1972. Despite this, the tramway has only received scarce scholarly attention. This article looks to address the situation. It does so by drawing attention to the fact that although the tramway was shut down, it lived on in art and literature. One example of this is “På Sporet af den Tabte Vogn” (1985) written by Klaus Rifbjerg. This short story has often been described as nostalgic. While this is not a misreading, it is an assessment that requires clarification. A close reading that draws on studies of nostalgia reveals that the short story does not boil down to a sentimental longing for a lost past. Rather, it thematises nostalgia for the Copenhagen tramway, questioning such remembrances’ status and relevance in contemporary society. This means that, ultimately, the short story can be seen as part of a broader tendency in writing about closures of electric public transport networks in Western Europe and North America: it works as a counternarrative to notions of progress, an antidote to predominant ideas of urban development in the mid-twentieth century.
Case Report: Antibiotic Irrigation and Drainage Tube for Managing Chronic Suppurative Otitis Media After Cochlear Implantation
Authors: Li Jiaying , Wang Ningyu , Zhang Juan
Published: April 2024

Cochlear implantation (CI) is the most effective solution for patients with severe-to-profound sensorineural hearing loss, especially in children. However, a major postoperative complication, known as chronic suppurative otitis media (CSOM), poses challenges for both doctors and families of the patients, which can affect post-CI hearing outcomes. We present the case of post-CI CSOM in a 15-year-old girl. She had been utilizing a unilateral cochlear implant for 7 years and had been experiencing intermittent earache and discharge in her only audible ear for the past 15 months. After antibiotic treatment failed to resolve her symptoms, we opted for a tympanomastoidectomy, and removed the receiver-stimulator package while keeping the electrode inside her cochlea. Simultaneously, we inserted an irrigation and drainage tube into the mastoid and middle ear space to discharge the exudate and control infection by applying topical antibiotics. The patient’s ear discharge had resolved within 1 month, and her tympanic membrane healed naturally. Our successful experience shows that antibiotic irrigation and draining have effectively controlled infection and accelerated wound healing in this patient with post-CI CSOM, and it further prompted the patient to undergo bilateral CI 9 months later.
Topical Preparations for Reducing Cutibacterium acnes Infections in Shoulder Surgery: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
Authors: Sewpaul Yash , Huynh Richard , Leung Brook , Alcock Harry , Nayar Sandeep Krishan , Rashid Mustafa S.
Published: April 2024

Background:

Cutibacterium acnes ( C acnes) is a commensal skin bacterium, primarily found in sebaceous glands and hair follicles, with a high prevalence in the shoulder region. It is the most common pathogenic organism in prosthetic joint infections after shoulder arthroplasty. Because of its low virulence, its diagnosis remains difficult.

Purpose:

To evaluate the relative effects of topical preparations in reducing C acnes in shoulder surgery.

Study Design:

Meta-analysis; Level of evidence, 1.

Methods:

We searched the MEDLINE, Embase, PsychINFO, and Cochrane Library databases in March 2022. Randomized controlled trials (RCTs) comparing any form of topical preparation in arthroscopic or open shoulder surgery were included. The primary outcome was a reduction in the number of positive C acnes cultures. Secondary outcomes were adverse events related to the application of topical preparations. We performed a network meta-analysis to facilitate simultaneous comparisons between multiple preparations across studies. We calculated differences between preparations using odds ratios and their 95% CIs. The risk of bias was assessed using the Cochrane risk-of-bias tool.

Results:

The search yielded 17 RCTs (1350 patients), of which 9 were suitable for the network meta-analysis (775 patients). Overall, 2 RCTs were deemed as having a low risk of bias, and 15 raised “some concerns” of bias. Preparations included benzoyl peroxide (BPO), BPO combined with clindamycin, chlorhexidine gluconate, hydrogen peroxide, povidone-iodine, and water with soap. Only BPO resulted in significantly lower odds of a positive C acnes culture compared with placebo or soap and water (odds ratio, 0.12 [95% CI, 0.04-0.36]). There was no statistically significant difference with all other topical preparations. The only adverse events were skin irritation from BPO and chlorhexidine gluconate in a small number of reported cases.

Conclusion:

BPO was the most effective topical agent in reducing the prevalence of C acnes in shoulder surgery. These results were limited by a combination of indirect and direct data. Future studies should focus on establishing the optimal frequency and duration of preoperative BPO to further reduce the burden of C acnes.

Registration:

CRD42022310312 (PROSPERO).
Clinical Outcomes and Graft Resorption After Metal-Free Bone Block Suture Tape Cerclage Fixation for Recurrent Anterior Shoulder Instability: A Computed Tomography Analysis
Authors: Hachem Abdul-ilah , Diaz-Apablaza Eduardo , Molina-Creixell Andres , Ruis Xavi , Videla Sebastian , Luis Agulló Jose
Published: April 2024

Background:

Glenoid reconstruction with a bone block for anterior glenoid bone loss (GBL) has shown excellent outcomes. However, fixation techniques that require metal implants are associated with metal-related complications and bone graft resorption.

Hypothesis:

Arthroscopic glenoid reconstruction using a tricortical iliac crest bone graft (ICBG) and metal-free suture tape cerclage fixation can safely and effectively restore the glenoid surface area in patients with recurrent anterior shoulder instability and anterior GBL.

Study Design:

Case series; Level of evidence, 4.

Methods:

Adult patients (≥18 years) of both sexes with recurrent anterior shoulder instability and anterior GBL ≥15% were enrolled. These patients underwent arthroscopic glenoid reconstruction with ICBGs and metal-free suture tape cerclage fixation. The effectiveness and clinical outcomes with this technique were evaluated at 24 months using functional scores. Resorption of the graft articular surface was assessed by computed tomography, with the graft surface divided into 6 square areas aligned in 2 columns. Descriptive analysis was conducted.

Results:

A total of 23 consecutive patients met inclusion criteria (22 male, 1 female; mean age, 30.5 ± 7.9 years). The mean preoperative GBL was 19.7% ± 3.4%, and there were 15 allograft and 8 autograft ICBGs. All patients exhibited graft union at 3 months. The median follow-up was 38.5 months (interquartile range, 24-45 months). The Western Ontario Shoulder Instability Index, Rowe, Constant-Murley, and Subjective Shoulder Value scores improved from preoperatively (35.1%, 24.8, 83.1, and 30.9, respectively) to postoperatively (84.7%, 91.1, 96.0, and 90.9, respectively) ( P < .001). No differences in clinical scores were observed between the graft types. One surgical wound infection was reported, and 2 patients (8.7% [95% CI, 2.4%-26.8%]) required a reoperation. The mean overall glenoid surface area increased from 80.3% ± 3.5% to 117.0% ± 8.3% immediately after surgery before subsequently reducing to 98.7% ± 6.2% and 95.0% ± 5.7% at 12 and 24 months, respectively ( P < .001). The mean graft resorption rate was 18.1% ± 7.9% in the inner column and 80.3% ± 22.4% in the outer column. Additionally, 3 patients treated with an allograft (20.0% [95% CI, 7.1%-45.2%]), including the 2 with clinical failures, exhibited complete graft resorption at the last follow-up.

Conclusion:

Arthroscopic glenoid reconstruction using an ICBG and metal-free suture tape cerclage fixation was safe and effective, yielding excellent clinical outcomes. Resorption of the graft articular surface predominantly affected the nonloaded areas beyond the best-fit circle perimeter.
Self-regulatory Sex Motives Scale in Online Dating: Exploratory Factor Analysis and Internal Consistency
Authors: Fereidooni Fatemeh , Daniels Judith K. , Lommen Miriam J. J.
Published: April 2024

Risky sex behavior is common among online dating users. Understanding the motives behind risky sex behavior might help identify suitable targets for prevention. We developed the Self-regulatory Sex Motives Scale in Online Dating (SSOD) to assess sex motives for casual sex in online dating users. This study evaluated the psychometric properties of the SSOD and examined the relationship between sex motives indexed by the SSOD and risky sex behavior. The new scale showed high internal consistency. Exploratory factor analysis suggested a one-factor solution. Sex motives were related to a higher frequency of having sex on the first date.
The effect of game-based approaches on decision-making, knowledge, and motor skill: A systematic review and a multilevel meta-analysis
Authors: Manninen Mika , Magrum Eric , Campbell Sara , Belton Sarahjane
Published: April 2024

This study aimed to compare the effect between game-based approaches (GBAs) and traditional skill approaches on decision-making, knowledge and motor skill in physical education students and athletes. A systematic review and meta-analysis of experimental studies available before October 2023 was conducted. The initial search yielded 8431 articles, with 28 articles ( n = 1600) meeting the inclusion criteria. Studies were analyzed using three-level random-effects models with a robust variance estimation. Outcomes were computed as raw mean differences and Hedges’s g effect sizes. Results indicate that GBAs have a positive heterogeneous effect on decision-making in game situations (ES = 11.41%; 95% CI [4.39, 18.43]) and motor skill in skill tests ( g = 0.36; 95% CI [0.14, 0.57]). GBAs did not have an effect on knowledge ( g = 0 .37; 95% CI [−0.12, 0.86]) or motor skill in game situations (ES = 1.13%; 95% CI [−2.43, 4.68]). Meta-regression analyses revealed that the experience of the interventionist, the quality of the studies, and the comparison condition significantly influence the impact of GBAs on motor skill tests. More detailed and transparent reporting of trials would benefit the field.
Numerical analysis of the effect of the duct geometry on the hydrodynamic performance of rim-driven thruster
Authors: Jiang Wen , Zhao jin , Bian Tao , Yu Wuxin
Published: April 2024

This paper studies the effect of the duct geometry on the hydrodynamic performance of rim-driven thruster (RDT) based on Computational Fluid Dynamics (CFD) method. The effect of the thickness of the duct, the radius of the leading edge of the duct and the geometry of the trailing edge of the duct on the thrust coefficient, torque coefficient and efficiency are investigated and analyzed. The conclusion shows the thrust coefficient increases with the thickness of the duct decreasing, however the torque coefficient increases with the increase of the thickness of the duct, so the efficiency increasing with the decrease of the thickness of the duct. On the other hand, the radius of the leading edge of the duct has no significant effect on the thrust coefficient of the RDT. However, the torque coefficient of RDT decreases with the increase of the radius of the leading edge of the duct, so the efficiency of RDT increases with the increase of the radius of the leading edge of the duct. A comprehensive comparison shows that the RDT 15-0.5 (the duct thickness is 15 mm, the ratio of the radius of the leading edge of the duct and the duct thickness is 0.5) has the best hydrodynamic performance among the investigated RDT models in this work.
Dexamethasone Intravitreal Implant to Treat Persistent Full-Thickness Macular Hole
Authors: Pellegrini Francesco , Barosco Guido , Trento Barbara , Rapizzi Emilio , Zemella Nicola
Published: April 2024

Purpose: To describe a new technique for the secondary repair of persistent full-thickness macular holes (FTMHs). Methods: This series evaluated 3 cases of a persistent FTMH after pars plana vitrectomy, internal limiting membrane peeling, and 20% sulfur hexafluoride gas tamponade. After at least 4 weeks (mean, 36.3; range, 32-40) of unsuccessful topical treatment with nonsteroidal anti-inflammatory drugs, an intravitreal dexamethasone implant was injected. Results: The intravitreal dexamethasone implant led to anatomic closure and visual improvement in all 3 cases over a 3-month follow-up. Conclusions: An intravitreal dexamethasone implant could be considered in the management of selected cases of persistent FTMH. Further studies and a consistent number of cases are needed to fully understand the role of intravitreal dexamethasone implants in persistent FTMHs.
A Case Study from the Overexpression of OsTZF5, Encoding a CCCH Tandem Zinc Finger Protein, in Rice Plants Across Nineteen Yield Trials
Authors: Grondin Alexandre , Natividad Mignon A. , Ogata Takuya , Jan Asad , Gaudin Amélie C. M. , Trijatmiko Kurniawan R. , Liwanag Evelyn , Maruyama Kyonoshin , Fujita Yasunari , Yamaguchi-Shinozaki Kazuko , Nakashima Kazuo , Slamet-Loedin Inez H. , Henry Amelia
Published: April 2024

Background

Development of transgenic rice overexpressing transcription factors involved in drought response has been previously reported to confer drought tolerance and therefore represents a means of crop improvement. We transformed lowland rice IR64 with OsTZF5, encoding a CCCH-tandem zinc finger protein, under the control of the rice LIP9 stress-inducible promoter and compared the drought response of transgenic lines and nulls to IR64 in successive screenhouse paddy and field trials up to the T6 generation.

Results

Compared to the well-watered conditions, the level of drought stress across experiments varied from a minimum of − 25 to − 75 kPa at a soil depth of 30 cm which reduced biomass by 30–55% and grain yield by 1–92%, presenting a range of drought severities. OsTZF5 transgenic lines showed high yield advantage under drought over IR64 in early generations, which was related to shorter time to flowering, lower shoot biomass and higher harvest index. However, the increases in values for yield and related traits in the transgenics became smaller over successive generations despite continued detection of drought-induced transgene expression as conferred by the LIP9 promoter. The decreased advantage of the transgenics over generations tended to coincide with increased levels of homozygosity. Background cleaning of the transgenic lines as well as introgression of the transgene into an IR64 line containing major-effect drought yield QTLs, which were evaluated starting at the BC3F1 and BC2F3 generation, respectively, did not result in consistently increased yield under drought as compared to the respective checks.

Conclusions

Although we cannot conclusively explain the genetic factors behind the loss of yield advantage of the transgenics under drought across generations, our results help in distinguishing among potential drought tolerance mechanisms related to effectiveness of the transgenics, since early flowering and harvest index most closely reflected the levels of yield advantage in the transgenics across generations while reduced biomass did not.
Radiomics-based discrimination of coronary chronic total occlusion and subtotal occlusion on coronary computed tomography angiography
Authors: Li Jun , Ren Lichen , Guo Hehe , Yang Haibo , Cui Jingjing , Zhang Yonggao
Published: April 2024

Objectives

Differentiating chronic total occlusion (CTO) from subtotal occlusion (SO) is often difficult to make from coronary computed tomography angiography (CCTA). We developed a CCTA-based radiomics model to differentiate CTO and SO.

Methods

A total of 66 patients with SO underwent CCTA before invasive angiography and were matched to 66 patients with CTO. Comprehensive imaging analysis was conducted for all lesioned vessels, involving the automatic identification of the lumen within the occluded segment and extraction of 1,904 radiomics features. Radiomics models were then constructed to assess the discriminative value of these features in distinguishing CTO from SO. External validation of the model was performed using data from another medical center.

Results

Compared to SO patients, CTO patients had more blunt stumps (internal: 53/66 (80.3%) vs. 39/66 (59.1%); external: 36/50 (72.0%) vs. 20/50 (40.0%), both p < 0.01), longer lesion length (internal: median length 15.4 mm[IQR: 10.4-22.3 mm] vs. 8.7 mm[IQR: 4.9-12.6 mm]; external:11.8 mm[IQR: 6.1-23.4 mm] vs. 6.2 mm[IQR: 3.5-9.1 mm]; both p < 0.001). Sixteen unique radiomics features were identified after the least absolute shrinkage and selection operator regression. When added to the combined model including imaging features, radiomics features provided increased value for distinguishing CTO from SO (AUC, internal: 0.772 vs. 0.846; p = 0.023; external: 0.718 vs. 0.781, p = 0.146).

Conclusions

The occluded segment vessels of CTO and SO have different radiomics signatures. The combined application of radiomics features and imaging features based on CCTA extraction can enhance diagnostic confidence.
Effect of diminished ovarian reserve on the outcome of fresh embryo transfer in IVF/ICSI cycles among young women: A retrospective cohort study
Authors: Zhu Suqin , Jiang Wenwen , Liao Xiuhua , Sun Yan , Chen Xiaojing , Zheng Beihong
Published: April 2024

Objective

This study aims to investigate the effect of diminished ovarian reserve (DOR) on the clinical outcomes and maternal and infant safety of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) procedures in young women aged ≤ 35 years.

Methods

A retrospective cohort study was performed to analyze the clinical data of 4,203 infertile women aged ≤ 35 years who underwent fresh embryo transfer (ET) in IVF/ICSI cycles. The data were collected from their initial visits to Fujian Maternity and Child Health Hospital between January 2015 and January 2022. Based on their ovarian reserve, the participants were categorized into two groups: DOR group (n = 1,027) and non-DOR group (n = 3,176). A propensity score matching (PSM) method was employed to ensure a relatively balanced distribution of covariates. The primary outcome assessed in this study was the live birth rate, while the secondary observation indicators included rates of high-quality embryo development, blastocyst formation, clinical pregnancy, and miscarriage, along with perinatal complications, neonatal birth weight, and the incidence of low birth weight (LBW).

Results

The DOR group showed notably lowered rates of blastocyst formation (59.8% vs. 64.1%), embryo implantation (29.8% vs.33.3%), clinical pregnancy (47.9% vs. 53.6%), and live birth (40.6% vs. 45.7%) compared to the non-DOR group (all P < 0.05). However, no statistically significant differences were observed in the high-quality embryo rate, miscarriage rate, perinatal complications, neonatal birth weight, or LBW incidence in infants between both groups (all P > 0.05).

Conclusion

DOR has been found to reduce both clinical pregnancy and live birth rates in young females undergoing fresh ET in IVF/ICSI cycles. However, this reduction does not increase the risk of perinatal complications or LBW of infants through live birth cycles.
A qualitative study of leaders’ experiences of handling challenges and changes induced by the COVID-19 pandemic in rural nursing homes and homecare services
Authors: Glette Malin Knutsen , Kringeland Tone , Samal Lipika , Bates David W. , Wiig Siri
Published: April 2024

Background

The COVID-19 pandemic had a major impact on healthcare services globally. In care settings such as small rural nursing homes and homes care services leaders were forced to confront, and adapt to, both new and ongoing challenges to protect their employees and patients and maintain their organization's operation. The aim of this study was to assess how healthcare leaders, working in rural primary healthcare services, led nursing homes and homecare services during the COVID-19 pandemic. Moreover, the study sought to explore how adaptations to changes and challenges induced by the pandemic were handled by leaders in rural nursing homes and homecare services.

Methods

The study employed a qualitative explorative design with individual interviews. Nine leaders at different levels, working in small, rural nursing homes and homecare services in western Norway were included.

Results

Three main themes emerged from the thematic analysis: “Navigating the role of a leader during the pandemic,” “The aftermath – management of COVID-19 in rural primary healthcare services”, and “The benefits and drawbacks of being small and rural during the pandemic.”

Conclusions

Leaders in rural nursing homes and homecare services handled a multitude of immediate challenges and used a variety of adaptive strategies during the COVID-19 pandemic. While handling their own uncertainty and rapidly changing roles, they also coped with organizational challenges and adopted strategies to maintain good working conditions for their employees, as well as maintain sound healthcare management. The study results establish the intricate nature of resilient leadership, encompassing individual resilience, personality, governance, resource availability, and the capability to adjust to organizational and employee requirements, and how the rural context may affect these aspects.
Long noncoding RNA UNC5B-AS1 suppresses cell proliferation by sponging miR-24-3p in glioblastoma multiforme
Authors: Song Ying , Chen Baodong , Jiao Huili , Yi Li
Published: April 2024

Background

Glioblastoma multiforme (GBM) is the most common primary CNS tumor, characterized by high mortality and heterogeneity. However, the related lncRNA signatures and their target microRNA (miRNA) for GBM are still mostly unknown. Therefore, it is critical that we discover lncRNA markers in GBM and their biological activities.

Materials and methods

GBM-related RNA-seq data were obtained from the Cancer Genome Atlas (TCGA) database. The “edger” R package was used for differently expressed lncRNAs (DELs) identification. Then, we forecasted prospective miRNAs that might bind to lncRNAs by Cytoscape software. Survival analysis of those miRNAs was examined by the starBase database, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the miRNAs’ target genes was conducted by the Gene Set Enrichment Analysis (GSEA) database and R software. Moreover, the proliferative ability of unc-5 netrin receptor B antisense RNA 1 (UNC5B-AS1) cells was evaluated by Cell Counting Kit-8 (CCK-8) analysis. Mechanistically, the regulatory interaction between UNC5B-AS1 and miRNA in GBM biological processes was studied using CCK-8 analysis.

Results

Our results indicated that overexpression of UNC5B-AS1 has been shown to suppress GBM cell growth. Mechanistically, miR-24-3p in GBM was able to alleviate the anti-oncogenic effects of UNC5B-AS1 on cell proliferation.

Conclusion

The discovery of the novel UNC5B-AS1-miR-24-3p network suggests possible lncRNA and miRNA roles in the development of GBM, which may have significant ramifications for the analysis of clinical prognosis and the development of GBM medications.
Enhancing therapeutic efficacy in luminal androgen receptor triple-negative breast cancer: exploring chidamide and enzalutamide as a promising combination strategy
Authors: Zhao Ya-Xin , Wang Han , Zhang Si-Wei , Zhang Wei-Xin , Jiang Yi-Zhou , Shao Zhi-Ming
Published: April 2024

Extensive exploration of the molecular subtypes of triple-negative breast cancer (TNBC) is critical for advancing precision medicine. Notably, the luminal androgen receptor (LAR) subtype has attracted attention for targeted treatment combining androgen receptor antagonists and CDK4/6 inhibitors. Unfortunately, this strategy has proven to be of limited efficacy, highlighting the need for further optimization. Using our center’s comprehensive multiomics dataset (n = 465), we identified novel therapeutic targets and evaluated their efficacy through multiple models, including in vitro LAR cell lines, in vivo cell-derived allograft models and ex vivo patient-derived organoids. Moreover, we conducted flow cytometry and RNA-seq analysis to unveil potential mechanisms underlying the regulation of tumor progression by these therapeutic strategies. LAR breast cancer cells exhibited sensitivity to chidamide and enzalutamide individually, with a drug combination assay revealing their synergistic effect. Crucially, this synergistic effect was verified through in vivo allograft models and patient-derived organoids. Furthermore, transcriptomic analysis demonstrated that the combination therapeutic strategy could inhibit tumor progression by regulating metabolism and autophagy. This study confirmed that the combination of histone deacetylase (HDAC) inhibitors and androgen receptor (AR) antagonists possessed greater therapeutic efficacy than monotherapy in LAR TNBC. This finding significantly bolsters the theoretical basis for the clinical translation of this combination therapy and provides an innovative strategy for the targeted treatment of LAR TNBC.