bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of geomorphic signatures of active tectonics in the Wadi Hagul Basin, Northwest Gulf of Suez, Egypt: insights from SRTM derived geomorphic indices and watershed analysis
Authors: Arnous Mohamed O. , Hegazi Ahmed M. , El-Rayes Ahmed E. , Almoazamy Ahmed A.
Published: August 2023

The satellite data, include Landsat 7 Enhanced Thematic Mapper (ETM+), Landsat-8 (OLI), Shuttle Radar Topography Mission (SRTM), were processed and interpreted for creating an integrated geospatial map of the geomorphic indices (GI) of Wadi Hagul Basin (WHB). The present study is considered new, useful, and valuable in northwest of Gulf of Suez region to evaluate active tectonics using SRTM resulting drainage network and GI. Where fairly slight studies on active tectonics recognized on GI were prepared in the investigated area. The GI includes; Ratio of valley floor width to valley height (Vf), Transverse topographic symmetry factor (T), Stream length-gradient index (SL), Drainage basin shape (Bs), hypsometric integral (Hi), geomorphological landform and watershed analysis. Also, GI were integrated and combined with the seismic and structural lineaments intensities maps to create an integrated single index map. The morphotectonic geo-spatial distribution hazards map reveals that the high risky area is 82.75% of the total area, the moderate-risk area is 16.51%, and the low risky morph-tectonic area is 0.81%. Based on this map, it is necessary for planners and decision makers to extremely study attractive applicable action concerning the recommended mitigation measurements from this study to avoid any serious future problems in WHB and its surroundings areas.
Research Progress on Pyroptosis in Hematological Malignancies
Authors: Lyu Tianxin , Yin Qingsong
Published: August 2023

Opinion statement

Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have shown that pyroptosis can be involved in the pathological processes of many diseases, such as cancers, atherosclerosis, diabetic nephropathy, and blood diseases. However, the specific mechanisms by which pyroptosis participates in the occurrence and development of hematological malignant tumors still need further exploration. This article reviews the characteristics of pyroptosis and the regulatory mechanisms promoting or inhibiting pyroptosis and discusses the role of pyroptosis in hematological malignant tumors, which could provide ideas for the clinical treatment of such tumors in the future.
LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells
Authors: Zhang Te , Leng Yahui , Duan Mengjing , Li Zihang , Ma Yongqing , Huang Chengyang , Shi Qin , Wang Yi , Wang Chengcheng , Liu Dandan , Zhao Xuan , Cheng Shuang , Liu Ao , Zhou Yang , Liu Jiaqi , Pan Zhongqiu , Zhang Huimei , Shen Li , Zhao Hongyan
Published: August 2023

Background

The incidence of ovarian cancer ranks third among gynecologic malignancies, but the mortality rate ranks first.

Methods

The expression of GAS5 is low in ovarian cancer and is associated with the low survival of ovarian cancer patients according to public ovarian cancer databases. GAS5 overexpression inhibited ovarian malignancy by affecting the proliferation and migratory abilities in OVCAR3 and A2780 cells. GAS5 overexpression increased the rate of cell apoptosis, and the cells were blocked in the G1 phase as assessed by flow cytometry.

Results

We found that hnRNPK was a potential target gene, which was regulated negatively by GAS5 based on RNA-pulldown and mass spectrometry analysis. Mechanistically, GAS5 affected the inhibition of the PI3K/AKT/mTOR pathways and bound the protein of hnRNPK, which influenced hnRNPK stability. Furthermore, rescue assays demonstrated hnRNPK was significantly involved in the progression of ovarian cancer.

Conclusions

Our study showed one of the mechanisms that GAS5 inhibited ovarian cancer metastasis by down-regulating hnRNPK expression, and GAS5 can be used to predict the prognosis of ovarian cancer patients.

Graphical Abstract
Evaluation of the approach based on the maximum principal stress from the IIW-Recommendation for welded joints under proportional, multiaxial stress states
Authors: Fass Markus , Hecht Matthias , Baumgartner Jörg , Bauer Niklas
Published: August 2023

The IIW-Recommendation for fatigue design of welded joints and components presents two different evaluation approaches for multiaxial stress states under constant amplitude: an approach based on the maximum principal stress, which is only applicable under certain conditions, and the Gough-Pollard approach for the remaining cases. In the course of this work, this maximum principal stress-based approach is analyzed. It is examined in which cases the method is applicable, the advantages and disadvantages compared to the approach according to Gough-Pollard are discussed, and an evaluation according to the von Mises equivalent stress is presented as a third alternative. This is followed by a validation based on literature data on laser-welded steel joints using the nominal stress, hot spot stress, and effective notch stress concept.
Spying and imperfect commitment in first-price auctions: a case of tacit collusion
Authors: Fan Cuihong , Jun Byoung Heon , Wolfstetter Elmar G.
Published: August 2023

We analyze Stackelberg leadership in a first-price auction. Leadership is induced by an information system, represented by a spy, that leaks one bidder’s bid before others choose their bids. However, the leader may secretly revise his bid with some probability; therefore, the leaked bid is only an imperfect signal. Whereas leadership with perfect commitment exclusively benefits the follower, imperfect commitment yields a collusive outcome, even if the likelihood that the leader may revise his bid is arbitrarily small. This collusive impact shows up in all equilibria and is strongest in the unique pooling equilibrium which is also payoff dominant.
Spark plasma sintering of Al–SiC composites with high SiC content: study of microstructure and tribological properties
Authors: Leszczyńska-Madej Beata , Madej Marcin , Wąsik Anna , Garbiec Dariusz
Published: August 2023

The article presents the results of the microstructure and tribological properties of Al–xSiC composites (x = 70 and 90 wt% SiC) produced in spark plasma sintering (SPS). Due to their attractive thermal, physical, and mechanical properties, aluminum matrix composites with high-volume fractions of silicon carbide (> 50%) have become a major area of interest as a potential material for multifunctional electronic packaging and cryogenic applications. The SPS process was carried out in a vacuum atmosphere under various conditions. Composites with a density close to theoretical (96–98%) were obtained. X-ray diffraction and scanning electron microscopy with EDS analysis were used to characterize the microstructure. Mechanical properties were determined by hardness measurements and a three-point bending test. The tribological properties of the composites were determined utilizing a block-on-ring tribotester. As a criterion for wear resistance, weight loss measured under specific friction conditions, that is, depending on the type of material and the applied load, was adopted. The researched materials were characterized by an even distribution of the carbide phase in the matrix. Composites with the highest SiC phase content (90 wt%) had higher hardness (2537 HV1) and flexural strength (242 ± 15 MPa) with worse wear resistance at the same time. The weight loss of this composite was 0.43 and 0.76% for friction under loads of 100 and 200 N, respectively, and was 360 and 270% higher than that determined for the composites with the lower content of the SiC phase (70 wt%). The wear rate was three times higher for the Al-90wt%SiC composites.
High‐Resolution Local Earthquake Tomography Beneath the Zagros Simply Folded Belt (SFB): Implications for an Inhomogeneous Low‐Velocity Layer and Diapirism in the Upper Crust
Authors: Kianimehr H. , Kissling E. , Yaminifard F. , Tatar M.
Published: August 2023

Hormuz salt formation is considered the origin of the evaporated salt deposits in the Zagros and its ductile behavior has been known as the reason for the inhomogeneous deformation in the Zagros. However, our knowledge about this formation has been limited to the salt domes on the surface. In our study, local earthquakes recorded by a temporary dense seismological network of 17 stations, deployed in the southern margin of the Zagros Simply Folded Belt (SFB) in southwestern Iran, have been used for seismic imaging. The high‐resolution earthquake local tomography revealed the first geophysical evidence about the Hormuz salt layer and its extension at depth. There is an uneven layer located at a depth of 8–12 km as the origin of extruded salt in this region through a shear fault zone and the production of the Dashti Salt Dome at the Kuh‐e‐Namak Mountain. Based on the obtained results, this layer is characterized by low seismic velocity volumes with significant Vp/Vs ratio variations. The seismic image is also consistent with a major NW‐trending NE‐dipping reverse fault, probably responsible for the 9 April 2013 Kaki earthquake. At depth of around 4 km, smaller scale high velocity anomalies, characterized by a high Vp/Vs ratio, may be related to the fluid saturated sediments in the uppermost sedimentary layer.
Generation and Release Mechanism and Abatement Measures for Gas Supersaturation Downstream of Hydropower Dams: A Review
Authors: Zhang Bin , Fu Xiaoli , Li Kefeng , Li Ran , Guo Xinlei
Published: August 2023

Despite the considerable social and economic benefits of hydropower dams, they can cause total dissolved gas (TDG) supersaturation downstream of hydropower dams, which can harm fish through gas bubble trauma (GBT) and cause issues with aquatic ecology. This paper systematically reviewed the generation and release mechanism of TDG supersaturation, including three stages of TDG generation and release, to broaden the research ideas of TDG supersaturation and encourage the construction of environmentally friendly dams and other hydropower projects. The factors affecting the generation and release were summarized from the three stages of TDG generation and release, including temperature, momentum difference at the water‐air interface, and effective depth of bubble arrival. The research methods were introduced from four aspects: theoretical methods, field observations, experiments, and numerical simulations. The advantages, disadvantages, and application scopes of different research methods were outlined. Finally, the abatement measures in the three stages of TDG generation and release were introduced from the engineering and non‐engineering perspectives, and the future research directions were pointed out from the four aspects of TDG supersaturation generation and release mechanism, research methods, abatement measures, and management methods, including in‐depth study of whether gas‐liquid transfer through bubble surfaces or free surfaces dominates, consideration of bubble coalescence and rupture to improve the accuracy of numerical methods in TDG supersaturation prediction, the combination of engineering and non‐engineering measures to optimize TDG supersaturation abatement measures and consideration of artificial intelligence technology to improve hydropower project management methods.
Basal Channel System and Polynya Effect on a Regional Air‐Ice‐Ocean‐Biology Environment System in the Prydz Bay, East Antarctica
Authors: Wang Tao , Zhou Chunxia , Qian Yide , Chen Gang , Zhu Dongyu , Zhu Yikai , Liu Yong
Published: August 2023

The interaction of air‐ice‐ocean‐biology plays a key role in the global environment and sea‐level changes. The basal channel at the bottom of the Amery Ice Shelf (AIS) and the Mackenzie polynya are the intense sites for the interaction of air‐ice‐ocean‐biology in the Prydz Bay. In this study, the spatio‐temporal distribution characteristics of the complex basal channel system from the 1990s to 2019 are discovered and analyzed. The shapes of the channels are inverted‐V in the deep parts, gradually becoming inverted‐U as it develops in accordance with the direction of erosion. The deepest part of the basal channel system is over 800 m resulting from the meltwater plumes at the southernmost grounding zone. The linear and thinner channel region is the weakest and most sensitive part under ocean forcing leading to instability of the AIS (e.g., longitudinal fractures and calving). Conductivity‐temperature‐depth data are used to confirm the paths and shapes of the warm and cold water in the interaction. Channels can be divided into warm and cold‐water channels based on filled water masses. Cold water channels collect the fresh melting water and drain it out. Paths of cold‐water columns from different channels extend to the Mackenzie polynya area, which prevents warm water from entering the west AIS. Meltwater from the channels, warm water, brine produced by the Mackenzie polynya, and marine mammals in the polynya together constitute a complex regional environment system of dynamical air‐ice‐ocean‐biology interactions.
Autologous stem cell transplantation in adult patients with intermediate-risk acute myeloid leukemia in first complete remission and no detectable minimal residual disease. A comparative retrospective study with haploidentical transplants of the global committee and the ALWP of the EBMT
Authors: Chen Jia , Labopin Myriam , Pabst Thomas , Zhang Xi , Jiang Erlie , Tucci Alessandra , Cornelissen Jan , Meijer Ellen , Khevelidze Irma , Polge Emmanuelle , Wu Depei , Mohty Mohamad , Gorin Norbert-Claude
Published: August 2023

In patients with acute myeloid leukemia (AML) of intermediate-risk (IR) in first remission (CR1) with no measurable residual disease (MRD negative), the choice of the best consolidation is questionable. 1122 adult patients from 196 centers, transplanted in 2010-21 were analyzed: 547 received an autologous stem cell transplantation (ASCT) and 575 a Haploidentical donor transplant. Because of a significant interaction, comparisons were done separately for patients with wild-type FLT3 (FLT3-wt) and FLT3-ITD mutation (FLT3-ITD). In FLT3-wt patients, haploidentical transplants had two year lower relapse incidence (RI) (16.9% versus 32.6%; HR = 0.40,p < 0.001), higher NRM higher (17.2% vs 3.5%; HR = 7.02,p < 0.001), similar LFS (65.9% vs 63.8%;p = 0.37) and lower OS (73.2% vs 80.6%; HR = 1.69,p = 0.018). In FLT3-ITD patients, haploidentical transplants had two year lower RI (8.2% vs 47.8%; HR = 0.14, p < 0.001) higher NRM (20.2% vs 5.6%; HR = 3.43,p = 0.002), better LFS (71.5% vs 46.6%; HR = 0.53,p = 0.007) and similar OS (73.5% vs 61.9%;p = 0.44). In IR AML patients with FLT3-wt in MRD negative CR1, autologous stem cell transplantation is a valid option, while in patients with FLT3-ITD, haploidentical transplant is better. Whether autologous transplantation is superior to chemotherapy in FLT3-wt patients and the role of maintenance therapy with FLT3 inhibitors remain to be studied.
Knockdown of Porf-2 restores visual function after optic nerve crush injury
Authors: Chen Di , Sun Yi-Yu , Zhou Lai-Yang , Han Xu , Yang Shuo , Hong Fei-Yang , Yuan Yuan , Wu Xiao-Hua , Huang Guo-Hui , Cheng Yuan-Chi , Huang Ju , Feng Dong-Fu
Published: August 2023

Retinal ganglion cells (RGCs), the sole output neurons in the eyes, are vulnerable to diverse insults in many pathological conditions, which can lead to permanent vision dysfunction. However, the molecular and cellular mechanisms that contribute to protecting RGCs and their axons from injuries are not completely known. Here, we identify that Porf-2, a member of the Rho GTPase activating protein gene group, is upregulated in RGCs after optic nerve crush. Knockdown of Porf-2 protects RGCs from apoptosis and promotes long-distance optic nerve regeneration after crush injury in both young and aged mice in vivo. In vitro, we find that inhibition of Porf-2 induces axon growth and growth cone formation in retinal explants. Inhibition of Porf-2 provides long-term and post-injury protection to RGCs and eventually promotes the recovery of visual function after crush injury in mice. These findings reveal a neuroprotective impact of the inhibition of Porf-2 on RGC survival and axon regeneration after optic nerve injury, providing a potential therapeutic strategy for vision restoration in patients with traumatic optic neuropathy.
SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA
Authors: Zhang Qi , Hao Rongjiao , Chen Hongxia , Zhou Gangqiao
Published: August 2023

Human single-stranded DNA-binding protein homologs hSSB1 (SOSSB1) and hSSB2 (SOSSB2) make a vital impact on maintaining genome stability as the B subunits of the sensor of single-stranded DNA complex (SOSS). However, whether and how SOSSB1 and SOSSB2 modulate mutual expression is unclear. This study, demonstrated that the depletion of SOSSB1 in cells enhances the stability of the SOSSB2 protein, and conversely, SOSSB2 depletion enhances the stability of the SOSSB1 protein. The levels of SOSSB1 and SOSSB2 proteins are mutually regulated through their competitive binding with SOSSA which associates with the highly conservative OB-fold domain in SOSSB1 and SOSSB2. The destabilized SOSSB1 and SOSSB2 proteins can be degraded via the proteasome pathway. Additionally, the simultaneous loss of SOSSB1 and SOSSB2 aggravates homologous recombination (HR)-mediated DNA repair defects, enhances cellular radiosensitivity and promotes cell apoptosis. In conclusion, in this study, we showed that SOSSB1 and SOSSB2 positively regulate HR repair and the interaction between SOSSA and SOSSB1 or SOSSB2 prevents the degradation of SOSSB1 and SOSSB2 proteins via the proteasome pathway.
Chemoenzymatic synthesis of genetically-encoded multivalent liquid N-glycan arrays
Authors: Lin Chih-Lan , Sojitra Mirat , Carpenter Eric J. , Hayhoe Ellen S. , Sarkar Susmita , Volker Elizabeth A. , Wang Chao , Bui Duong T. , Yang Loretta , Klassen John S. , Wu Peng , Macauley Matthew S. , Lowary Todd L. , Derda Ratmir
Published: August 2023

Cellular glycosylation is characterized by chemical complexity and heterogeneity, which is challenging to reproduce synthetically. Here we show chemoenzymatic synthesis on phage to produce a genetically-encoded liquid glycan array (LiGA) of complex type N-glycans. Implementing the approach involved by ligating an azide-containing sialylglycosyl-asparagine to phage functionalized with 50–1000 copies of dibenzocyclooctyne. The resulting intermediate can be trimmed by glycosidases and extended by glycosyltransferases yielding a phage library with different N-glycans. Post-reaction analysis by MALDI-TOF MS allows rigorous characterization of N-glycan structure and mean density, which are both encoded in the phage DNA. Use of this LiGA with fifteen glycan-binding proteins, including CD22 or DC-SIGN on cells, reveals optimal structure/density combinations for recognition. Injection of the LiGA into mice identifies glycoconjugates with structures and avidity necessary for enrichment in specific organs. This work provides a quantitative evaluation of the interaction of complex N-glycans with GBPs in vitro and in vivo.
Engaging an HIV vaccine target through the acquisition of low B cell affinity
Authors: Ronsard Larance , Yousif Ashraf S. , Nait Mohamed Faez Amokrane , Feldman Jared , Okonkwo Vintus , McCarthy Caitlin , Schnabel Julia , Caradonna Timothy , Barnes Ralston M. , Rohrer Daniel , Lonberg Nils , Schmidt Aaron , Lingwood Daniel
Published: August 2023

Low affinity is common for germline B cell receptors (BCR) seeding development of broadly neutralizing antibodies (bnAbs) that engage hypervariable viruses, including HIV. Antibody affinity selection is also non-homogenizing, insuring the survival of low affinity B cell clones. To explore whether this provides a natural window for expanding human B cell lineages against conserved vaccine targets, we deploy transgenic mice mimicking human antibody diversity and somatic hypermutation (SHM) and immunize with simple monomeric HIV glycoprotein envelope immunogens. We report an immunization regimen that focuses B cell memory upon the conserved CD4 binding site (CD4bs) through both conventional affinity maturation and reproducible expansion of low affinity BCR clones with public patterns in SHM. In the latter instance, SHM facilitates target acquisition by decreasing binding strength. This suggests that permissive B cell selection enables the discovery of antibody epitopes, in this case an HIV bnAb site.
Activating dynamic atomic-configuration for single-site electrocatalyst in electrochemical CO2 reduction
Authors: Hsu Chia-Shuo , Wang Jiali , Chu You-Chiuan , Chen Jui-Hsien , Chien Chia-Ying , Lin Kuo-Hsin , Tsai Li Duan , Chen Hsiao-Chien , Liao Yen-Fa , Hiraoka Nozomu , Cheng Yuan-Chung , Chen Hao Ming
Published: August 2023

One challenge for realizing high-efficiency electrocatalysts for CO2 electroreduction is lacking in comprehensive understanding of potential-driven chemical state and dynamic atomic-configuration evolutions. Herein, by using a complementary combination of in situ/operando methods and employing copper single-atom electrocatalyst as a model system, we provide evidence on how the complex interplay among dynamic atomic-configuration, chemical state change and surface coulombic charging determines the resulting product profiles. We further demonstrate an informative indicator of atomic surface charge (φe) for evaluating the CO2RR performance, and validate potential-driven dynamic low-coordinated Cu centers for performing significantly high selectivity and activity toward CO product over the well-known four N-coordinated counterparts. It indicates that the structural reconstruction only involved the dynamic breaking of Cu–N bond is partially reversible, whereas Cu–Cu bond formation is clearly irreversible. For all single-atom electrocatalysts (Cu, Fe and Co), the φe value for efficient CO production has been revealed closely correlated with the configuration transformation to generate dynamic low-coordinated configuration. A universal explication can be concluded that the dynamic low-coordinated configuration is the active form to efficiently catalyze CO2-to-CO conversion.
Dual donor-acceptor covalent organic frameworks for hydrogen peroxide photosynthesis
Authors: Qin Chencheng , Wu Xiaodong , Tang Lin , Chen Xiaohong , Li Miao , Mou Yi , Su Bo , Wang Sibo , Feng Chengyang , Liu Jiawei , Yuan Xingzhong , Zhao Yanli , Wang Hou
Published: August 2023

Constructing photocatalytically active and stable covalent organic frameworks containing both oxidative and reductive reaction centers remain a challenge. In this study, benzotrithiophene-based covalent organic frameworks with spatially separated redox centers are rationally designed for the photocatalytic production of hydrogen peroxide from water and oxygen without sacrificial agents. The triazine-containing framework demonstrates high selectivity for H2O2photogeneration, with a yield rate of 2111 μM h−1(21.11 μmol h−1and 1407 μmol g−1h−1) and a solar-to-chemical conversion efficiency of 0.296%. Codirectional charge transfer and large energetic differences between linkages and linkers are verified in the double donor-acceptor structures of periodic frameworks. The active sites are mainly concentrated on the electron-acceptor fragments near the imine bond, which regulate the electron distribution of adjacent carbon atoms to optimally reduce the Gibbs free energy of O2* and OOH* intermediates during the formation of H2O2.
Environmental gradients reveal stress hubs pre-dating plant terrestrialization
Authors: Dadras Armin , Fürst-Jansen Janine M. R. , Darienko Tatyana , Krone Denis , Scholz Patricia , Sun Siqi , Herrfurth Cornelia , Rieseberg Tim P. , Irisarri Iker , Steinkamp Rasmus , Hansen Maike , Buschmann Henrik , Valerius Oliver , Braus Gerhard H. , Hoecker Ute , Feussner Ivo , Mutwil Marek , Ischebeck Till , de Vries Sophie , Lorenz Maike , de Vries Jan
Published: August 2023

Plant terrestrialization brought forth the land plants (embryophytes). Embryophytes account for most of the biomass on land and evolved from streptophyte algae in a singular event. Recent advances have unravelled the first full genomes of the closest algal relatives of land plants; among the first such species was Mesotaenium endlicherianum. Here we used fine-combed RNA sequencing in tandem with a photophysiological assessment on Mesotaenium exposed to a continuous range of temperature and light cues. Our data establish a grid of 42 different conditions, resulting in 128 transcriptomes and ~1.5 Tbp (~9.9 billion reads) of data to study the combinatory effects of stress response using clustering along gradients. Mesotaenium shares with land plants major hubs in genetic networks underpinning stress response and acclimation. Our data suggest that lipid droplet formation and plastid and cell wall-derived signals have denominated molecular programmes since more than 600 million years of streptophyte evolution—before plants made their first steps on land.
Effects of racket moment of inertia on racket head speed, impact location and shuttlecock speed during the badminton smash
Authors: Towler H. , Mitchell S. R. , King M. A.
Published: August 2023

How the racket properties impact performance of the badminton smash is relatively unknown, and further insight could help players/coaches select the most appropriate racket. Three-dimensional position data of the racket and shuttlecock were collected (500 Hz) for 20 experienced badminton players performing a series of forehand smashes with five swingweight ($${I}_{s}$$

I
s

) perturbed rackets, ranging from 85–106 kg·cm2. $${I}_{s}$$

I
s

was calculated using a balance board and simple pendulum method, and modal analysis was performed using laser vibrometry to capture the fundamental frequency and distal node location for each racket. As $${I}_{s}$$

I
s

increased a reduction in racket head speed was found with on average a 0.7 m·s−1 decrease per 5 kg·cm2 increase in $${I}_{s}$$

I
s

, however this did not lead to slower shuttlecock speeds. The impact location tended to move closer to the tip as the fundamental frequency node moved closer to the tip (as $${I}_{s}$$

I
s

increased), providing some evidence that participants may subconsciously strike the shuttlecock at the node location to provide desirable sensory feedback. The increase in racket head speed but not shuttlecock speed was likely due to the distal increase in longitudinal impact location as $${I}_{s}$$

I
s

increased, as well as an increase in effective mass for a given impact location. Additionally, removal of the deformation component (additional racket head speed due to the racket noticeably bending and recovering) of racket head speed increased the effect size of the relationship with $${I}_{s}$$

I
s

, where rackets with greater $${I}_{s}$$

I
s

had larger deformation velocities. The research provides further insight into the smash performance characteristics of experienced badminton players, particularly based on racket properties. Further research is required to confirm the coincidence between node location and longitudinal impact location.
Lightweight and efficient dual-path fusion network for iris segmentation
Authors: Lei Songze , Shan Aokui , Liu Bo , Zhao Yanxiao , Xiang Wei
Published: August 2023

In order to tackle limitations of current iris segmentation methods based on deep learning, such as an enormous amount of parameters, intensive computation and excessive storage space, a lightweight and efficient iris segmentation network is proposed in this article. Based on the classical semantic segmentation network U-net, the proposed approach designs a dual-path fusion network model to integrate deep semantic information and rich shallow context information at multiple levels. Our model uses the depth-wise separable convolution for feature extraction and introduces a novel attention mechanism, which strengthens the capability of extracting significant features as well as the segmentation capability of the network. Experiments on four public datasets reveal that the proposed approach can raise the MIoU and F1 scores by 15% and 9% on average compared with traditional methods, respectively, and 1.5% and 2.5% on average compared with the classical semantic segmentation method U-net and other relevant methods. Compared with the U-net, the proposed approach reduces about 80%, 90% and 99% in terms of computation, parameters and storage, respectively, and the average run time up to 0.02 s. Our approach not only exhibits a good performance, but also is simpler in terms of computation, parameters and storage compared with existing classical semantic segmentation methods.
Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization
Authors: Yue Lei , Xu Xiaozhang , Dai Shipeng , Xu Fan , Zhao Wenhu , Gu Jian , Dai Xinzheng , Qian Xiaofeng
Published: August 2023

Approximately 25–30% of those affected by colorectal cancer (CRC), the most prevalent gastrointestinal malignancy, develop metastases. The survival rate of patients with liver metastasis of CRC (CRLM) remains low owing to its unpredictability and a lack of biomarkers that can be applied to distinguish groups at higher risk for CRLM among patients with CRC. Therefore, our study aimed to find biomarkers that can predict the risk of CRLM. Screening of the Gene Expression Omnibus database, supported by an analysis of clinically obtained tissue and serum data using qPCR and ELISA, in an attempt to identify relevant biomarkers, enabled us to determine that orosomucoid 1 (ORM1) was differentially expressed in liver metastases and primary tumors of patients with CRC. Functionally, overexpression of ORM1 promoted the epithelial-mesenchymal transition and the proliferative, migratory, and invasive activities of MC38 cells and activated the PI3K/AKT signaling pathway. Moreover, MC38 cells overexpressing ORM1 enhanced the tumor immune microenvironment by promoting macrophage M2 polarization and elevating interleukin-10 (IL-10) expression. In vivo experiments further confirmed in vitro results, indicating that liver metastases elevated by ORM1 were partially attenuated by the depletion of macrophages or IL-10. Considered together, ORM1 promotes CRC progression and liver metastasis by regulating tumor cell growth and inducing macrophage M2 polarization, which mediates tumor immune tolerance, and thus acts as a potential predictive marker and therapeutic target in CRLM.
Physics informed neural network for charged particles surrounded by conductive boundaries
Authors: Hafezianzade Fatemeh , Biagooi Morad , Oskoee SeyedEhsan Nedaaee
Published: August 2023

Molecular dynamics of charged particles in porous conductive media have received considerable attention in recent years due to their application in cutting-edge technologies such as batteries and supercapacitors. Due to the presence of long-range electrical interactions, induced charges present at the boundary, and the influence of boundary conditions, the simulation of these systems is more challenging than the simulation of typical molecular dynamic systems. Simulating these kinds of systems typically involves using a numerical solver to solve the Poisson equation, which is a very time-consuming procedure. Recently, Physics-Informed Neural Networks (PINNs) have been introduced as an alternative to numerical solutions of PDEs. In this paper, we present a new PINN-based model for predicting the potential of point-charged particles surrounded by conductive walls. As a result of the proposed PINN model, the mean square error is less than $$7\%$$

7
%

and $$R^{2}$$

R
2

score is more than $$90\%$$

90
%

for the corresponding example simulation. Results have been compared with typical neural networks and random forest as standard machine learning algorithms. The $$R^{2}$$

R
2

score of the random forest model was $$70\%$$

70
%

, and a standard neural network could not be trained well.
Structural equation modelling of work related musculoskeletal disorders among dumper operators
Authors: Kar Mohith Bekal , Aruna Mangalpady , Kunar Bijay Mihir
Published: August 2023

The aim of this study is to investigate the impact of personal factors, habitual factors, and work-related factors on work-related musculoskeletal disorders (WRMSDs) among dumper operators. In total, 248 dumper operators working in an iron ore mine were considered for this study. A questionnaire was developed and administered to collect dumper operators' personal, habitual, and work-related data. The reliability of the questionnaire was cross-checked by Cronbach alpha and the test–retest method. The values of Cronbach alpha for all latent variables were above 0.7, and the correlation coefficient of the questionnaire items at Time 1 and Time 2 was above 0.82. After verifying the validity (i.e., convergent and divergent) of the questionnaire data, the relationship between the factors under consideration was examined by structural equation modeling (SEM). The SEM demonstrated a moderate fit, with $$\frac{{\upchi }^{2}}{df}$$

χ

2

df

value of 1.386, comparative fit index (CFI) of 0.86, goodness-of-fit index (GFI) of 0.72, adjusted goodness-of-fit index (AGFI) of 0.69, Tucker-Lewis Index (TLI) of 0.83, normed fit index (NFI) of 0.71 and root mean square error of approximation (RMSEA) of 0.051. The SEM analysis revealed a positive relationship between WRMSDs and personal factors (with path coefficient = 0.313 and p < 0.05) as well as work-related factors (with path coefficient = 0.296 and p < 0.05). However, the relationship between WRMSDs and habitual factors was not statistically significant (with path coefficient = 0.142 and p > 0.05). Overall, this study provides valuable insights into the factors that influence the prevalence of WRMSDs among dumper operators. The findings highlight the significance of personal and work-related factors by which one can make a positive decision to prevent and reduce the incidence of WRMSDs among dumper operators.
Pictorial adaptation of the quality of recovery 15 scale and psychometric validation into a pediatric surgical population
Authors: Noll Eric , De Angelis Vincent , Bopp Claire , Chauvin Chloe , Talon Isabelle , Bennett-Guerrero Elliott , Lefebvre François , Pottecher Julien
Published: August 2023

Patient reported outcomes measures (PROMS) are important endpoints to measure patient health status in the perioperative setting. However, there are no good tools to measure PROMS in the pediatric surgical population. Patients 7 to 17 years old undergoing surgery were included and followed up for 1 day after surgery (POD1). At POD1 the patients were asked to rate their overall postoperative recovery using a 100-mm visual analog scale (VAS). The primary outcome was the pediatric QoR-15 score on postoperative day 1 (POD1). 150 patients completed the study. The mean (SD) pediatric QoR-15F scores were 132.1 (14.1) and 111.0 (27.0), preoperatively and on POD1, respectively. Convergent validity confirmed with Pearson (r) correlation between the postoperative pediatric QoR-15F and the patient-rated global recovery assessment was 0.72 (95% confidence interval [0.63–0.79]; p < 10–16). Concerning reliability, internal consistency of the pediatric QoR-15 assessed by Cronbach’s alpha was 0.90. The test–retest concordance correlation coefficient was 0.92; 95% CI [0.83–0.96]. Split-half alpha was 0.74. The pictorial pediatric version of the QoR-15F showed good validity, reliability, responsiveness, acceptability and feasibility. This PROMS should be considered for clinical care and research in the perioperative pediatric patient setting.

Trial Registration: NCT04453410 on clinicaltrials.gov.
Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic
Authors: Nzilu Dennis Mwanza , Madivoli Edwin Shigwenya , Makhanu David Sujee , Wanakai Sammy Indire , Kiprono Gideon Kirui , Kareru Patrick Gachoki
Published: August 2023

In recent ages, green nanotechnology has gained attraction in the synthesis of metallic nanoparticles due to their cost-effectiveness, simple preparation steps, and environmentally-friendly. In the present study, copper oxide nanoparticles (CuO NPs) were prepared usingParthenium hysterophoruswhole plant aqueous extract as a reducing, stabilizing, and capping agent. The CuO NPs were characterized via UV–Vis Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), powder X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS). The UV–Vis spectra of CuO NPs showed a surface plasmonic resonance band to occur at 340 nm. FTIR analysis revealed the presence of secondary metabolites on the surface of CuO NPs, with a characteristic Cu–O stretching band being identified at 522 cm−1. Scanning electron micrographs and transmission electron micrographs showed that CuO NPs were nearly spherical, with an average particle of 59.99 nm obtained from the SEM micrograph. The monoclinic crystalline structure of CuO NPs was confirmed using XRD, and crystallite size calculated using the Scherrer-Debye equation was found to be 31.58 nm. DLS showed the presence of nanoparticle agglomeration, which revealed uniformity of the CuO NPs. Furthermore, the degradation ability of biosynthesized nanoparticles was investigated against rifampicin antibiotic. The results showed that the optimum degradation efficiency of rifampicin at 98.43% was obtained at 65℃ temperature, 50 mg dosage of CuO NPs, 10 mg/L concentration of rifampicin solution, and rifampicin solution at pH 2 in 8 min. From this study, it can be concluded that CuO NPs synthesized fromParthenium hysterophorusaqueous extract are promising in the remediation of environmental pollution from antibiotics. In this light, the study reports thatParthenium hysterophorus-mediated green synthesis of CuO NPs can effectively address environmental pollution in cost-effective, eco-friendly, and sustainable ways.
Total and differential ionization cross sections in collision between nitrogen atom and singly charged sodium ion
Authors: Al-Ajaleen M. , Tőkési K.
Published: August 2023

We present a theoretical study of the ionization of nitrogen atom by a singly charged sodium ion using the classical trajectory Monte Carlo method. Although we suffer from a lack of cross section data of this collision system, the knowledge of the basic cross sections is essential in fusion science, because this reaction has potential applications in the diagnostic of magnetically confined fusion plasmas. In our investigations, the Na+–N collision system is reduced to a three-body problem. The interaction between the collision partners is described by the Garvey-type model potential. The results of our study provide insight into the dynamics of singly charged sodium–nitrogen interactions. The total cross sections are presented in the impact energy range between 10 keV and 10 MeV and compared them with the available experimental data. The single and double differential cross sections are presented at 30, 40, 50 and 60 keV energies related to the energies of the plasma diagnostic used in the nuclear fusion.
Extracting spatial knowledge from track and field broadcasts for monocular 3D human pose estimation
Authors: Baumgartner Tobias , Paassen Benjamin , Klatt Stefanie
Published: August 2023

Collecting large datasets for investigations into human locomotion is an expensive and labor-intensive process. Methods for 3D human pose estimation in the wild are becoming increasingly accurate and could soon be sufficient to assist with the collection of datasets for analysis into running kinematics from TV broadcast data. In the domain of biomechanical research, small differences in 3D angles play an important role. More precisely, the error margins of the data collection process need to be smaller than the expected variation between athletes. In this work, we propose a method to infer the global geometry of track and field stadium recordings using lane demarcations. By projecting estimated 3D skeletons back into the image using this global geometry, we show that current state-of-the-art 3D human pose estimation methods are not (yet) accurate enough to be used in kinematics research.
Co-delivery of streptomycin and hydroxychloroquine by labeled solid lipid nanoparticles to treat brucellosis: an animal study
Authors: Moez Narjes Morovati , Hosseini Seyed Mostafa , kalhori Fereshte , Shokoohizadeh Leili , Arabestani Mohammad Reza
Published: August 2023

Can brucellosis-related biochemical and immunological parameters be used as diagnostic and treatment indicators? The goal of this project was to look at biochemical parameters, trace elements, and inflammatory factors in the acute and chronic stages of brucellosis after treatment with streptomycin and hydroxychloroquine-loaded solid lipid nanoparticles (STR-HCQ-SLN). The double emulsion method was used for the synthesis of nanoparticles. Serum levels of trace elements, vitamin D, CRP, and biochemical parameters were measured in rats involved in brucellosis. The therapeutic effect of STR-HCQ-SLN was compared with that of free drugs. In both healthy and infected rats, serum concentrations of copper, zinc, iron, magnesium, potassium, and biochemical parameters of the liver were significantly different. By altering the serum levels of the aforementioned factors, treatment with STR-HCQ-SLN had a positive therapeutic effect on chronic brucellosis. Vitamin D levels declined (46.4%) and CRP levels rose (from 7.5 mg to less than 1 mg) throughout the acute and chronic stages of brucellosis. This study showed that by comparing the biochemical parameters and the levels of trace elements in the serum of healthy and diseased mice in the acute and chronic stages of brucellosis, it is possible to get help from other routine methods for diagnosis.
Carbon and oxygen isotope characteristics of carbonate rocks in the Mesoproterozoic Jixian System of the Ordos Basin and their implications
Authors: Xiaofeng Liu , Zenglin Hong , Jiwei Liang , Xiaodan Guo , Xuping Xue , Shifeng Li
Published: August 2023

The paleoenvironment of Jixian carbonate rocks in the Mesoproterozoic Ordos Basin is studied by carbon and oxygen isotope analyses, diagenetic environment analysis, and the restoration of paleosalinity and paleotemperature. The results indicate that the carbonate rocks of the Jixian System have always been in a near-surface environment and have not been deeply buried. The ranges of variation in δ13CPDB and δ18OPDB are relatively narrow, ranging from − 5.75 to 1.41‰ and − 8.88 to − 4.01‰, respectively, which is consistent with the stable tidal flat sedimentary environment during the Mesoproterozoic in the study area. The paleosalinity (Z) values range from 111.7 to 127.1, and the paleotemperature (T) values range from 32.7 to 57.33 °C, indicating a relatively warm paleoclimatic environment during the Mesoproterozoic era in the study area. The analysis shows that in a warm paleoclimatic environment, although carbon and oxygen isotopes, Z, and T have certain fluctuations, their ranges are relatively small, reflecting to some extent the stable tectonic environment of the study area during the Mesoproterozoic era. Comprehensive research shows that the Ordos Basin had a warm climate and a stable tectonic environment in the Mesoproterozoic, which may be a good response to the North China Block's position near the equator and continuous thermal subsidence in the Mesoproterozoic.
A novel plasmonic metal–semiconductor–insulator–metal (MSIM) color sensor compatible with CMOS technology
Authors: Asl A. Beheshti , Ahmadi H. , Rostami A.
Published: August 2023

Color detection is one of the top interests in both biological and industrial applications. Specifically, the Determination of the light wave characteristics is vital in photonic technology. One of the features in the color sense that should be found out is its wavelength or color. In this work, we propose a structure that can be used to detect RGB colors separately in an efficient way. The proposed detector consists of the plasmonic filter sensing desired wavelength (red, green, and blue) and the PN diode to convert the received photons to the electrical current. At the input intensity of 1 mW × cm−2, the current density for blue, green, and red colors are 27, 35, and 48 µA × cm−2, respectively. It is shown that the intensities needed to obtain the current densities of 0.1 µA × cm−2 are 3.94, 2.98, and 2.25 µW × cm−2 for the blue, green, and red spectra respectively. It should mention that by using high-precision photodetector structures such as PIN diode, the minimum detectable level can be decreased. Simple adjusting for desired wavelength and linear operation for different input intensities are the characteristics of the designed structure. This detector is compatible with CMOS technology and can be easily utilized in numerous applications, such as charge-coupled devices, displays, and cameras.
Study on reservoir optimal operation based on coupled adaptive ε constraint and multi strategy improved Pelican algorithm
Authors: He Ji , Guo Xiaoqi , Wang Songlin , Chen Haitao , Chai Fu-Xin
Published: August 2023

The optimal operation of reservoir groups is a strongly constrained, multi-stage, and high-dimensional optimization problem. In response to this issue, this article couples the standard Pelican optimization algorithm with adaptive ε constraint methods, and further improves the optimization performance of the algorithm by initializing the population with a good point set, reverse differential evolution, and optimal individual t-distribution perturbation strategy. Based on this, an improved Pelican algorithm coupled with adaptive ε constraint method is proposed (ε-IPOA). The performance of the algorithm was tested through 24 constraint testing functions to find the optimal ability and solve constraint optimization problems. The results showed that the algorithm has strong optimization ability and stable performance. In this paper, we select Sanmenxia and Xiaolangdi reservoirs as the research objects, establish the maximum peak-cutting model of terrace reservoirs, apply the ε-IPOA algorithm to solve the model, and compare it with the ε-POA (Pelican algorithm coupled with adaptive ε constraint method) and ε-DE (Differential Evolution Algorithm) algorithms, the results indicate that ε. The peak flow rate of the Huayuankou control point solved by the IPOA algorithm is 12,319 m3/s, which is much lower than the safe overflow flow rate of 22,000 m3/s at the Huayuankou control point, with a peak shaving rate of 44%, and other algorithms do not find effective solutions meeting the constraint conditions. This paper provides a new idea for solving the problem of flood control optimal operation of cascade reservoirs.
Catalytic cascade synthesis of cyanohydrin esters via water/O2-induced cyanide transfer from K3Fe(CN)6
Authors: Singh Anupam Kumar , Chauhan Shivani Singh , Bhadra Sukalyan
Published: August 2023

The Cu-catalyzed α-oxygenation of aryl benzyl ketones has been integrated with a unique water/O2-induced cyanide release process from K3Fe(CN)6 and a benzil-cyanide reaction to give a new entry to cyanohydrin esters.
Transformations of silver(i) chalcogenide clusters induced by halide ions as dopant components rather than surface active species
Authors: Gao Yu-Quan , Wu Wei-Hong , Mao Hui , Zhang Ya-Ge , Zhan Cai-Hong , Jiang Zhan-Guo
Published: August 2023

The distinctive transformation of a {Ag32} cluster was achieved by incorporating different halide ions, and the process induced high selectivity luminescence.
Optically active bis(aminophenols) and their metal complexes
Authors: Carbonel Halen , Mikulski Timothy D. , Nugraha Kahargyan , Johnston James , Wang Yichun , Brown Seth N.
Published: August 2023

Optically active bis(aminophenols) are prepared and stereoselectively metalated to form palladium and platinum bis(iminosemiquinone) and oxoosmium bis(amidophenoxide) complexes.