bluuebunny/crossref_metadata_2025 huggingface dataset:
Deficient skin proteins rescue of expression in patients with epidermolysis bullosa: efficacy of gentamicin
Authors: Artamonova Olga G. , Karamova Arfenya E. , Kubanov Alexey A. , Chikin Vadim V. , Monchakovskaya Ekaterina S.
Published: February 2024

Epidermolysis bullosa is a group of rare hereditary skin diseases based on mutations in the genes of structural proteins of the epidermis and the dermal-epidermal junction. Clinically, epidermolysis bullosa is characterized by the appearance of erosions and blisters on the skin and mucous membranes in response to any minor impact. Currently, the treatment of epidermolysis bullosa is only symptomatic. Pathogenetic methods of the epidermolysis bullosa therapy are under development. One of the new possible pathogenetic directions in the treatment of epidermolysis bullosa is aminoglycoside antibiotics (gentamicin, geneticin, paromomycin). A number of studies have shown the ability of gentamicin to promote readthrough terminating codon and resume the synthesis of type VII collagen in keratinocytes and fibroblasts in patients with epidermolysis bullosa with nonsense mutations in the COL7A1. The review presented the possibilities of gentamicin therapy for patients with epidermolysis bullosa, describes the mechanism of its action, summarizes data from clinical trials.
Phenotyping of Rh and Kell blood group antigen in thalassemia and its impact on alloimmunization in a tertiary care hospital
Authors: Gupta Sonia , Kumar Rajesh
Published: February 2024

Objectives:

Alloimmunization to red cell antigens is a dreaded complication in multitransfused patients, leading to difficulty in obtaining compatible red blood cell units and development of delayed hemolytic transfusion reactions. The objective of this study was to assess the impact of partial matched phenotype blood (for RhD, C, c, E, e, and Kell antigens) on alloimmunization in thalassemics versus non-phenotype matched blood (ABO & RhD).

Materials and Methods:

This cross-sectional study was conducted over a period of two years where 250 patients with thalassemias were enrolled. They were divided into two groups, patients in Group I (n = 180) who received partial matched phenotype blood since initiation of transfusion therapy and those in Group II (n = 70) subjects who received usual matched blood.

Statistical analysis:

All statistical calculations were done using statistical package for the social sciences (SPSS) 21 version. Data were described in terms of range, median (interquartile range [IQR]), frequencies, etc.

Results:

The median (IQR) age of the study population was 12 (7–18) years (range 6 months–36 years). The most common Rh antibodies were anti-D (2.85%), anti-E (2.85%), anti-C (1.42%), and anti-c (1.42%), and Kell antibodies were (7.1%). It was seen that chances of developing autoantibodies (37% vs. 5%), alloantibodies 11 (15.7% vs. 0%), and transfusion reactions 25 (35.7% vs. 3.3%) were more in Group II subjects as compared to Group I. A significant difference was seen with febrile non-hemolytic transfusion reactions in between two groups 0.001 (95% confidence interval 2.98–65.73).

Conclusions:

Patients with thalassemia should be typed for RhD (C, c, E, and e) and Kell antigen before initiation of transfusion, which will help in reducing the rate of alloimmunization, autoimmunization, and frequency of transfusion and will improve the overall survival rate in thalassemia.
Comparing redo surgery and stereotactic radiosurgery for recurrent, residual, and/or tumors showing progression in nonfunctioning pituitary adenomas: A systematic review and meta-analysis
Authors: Islam Muhammad Yousuf Ul , Akhtar Saad , Nasir Roua , Anis Saad Bin , Iftikhar Haissan , Khan Farhan Raza , Martins Russell Seth , Bari Muhammad Ehsan , Ahmed Urooba
Published: February 2024

Background:

Non-functioning pituitary adenomas (NFPAs) are well-differentiated benign tumors originating from the adenohypophyseal cells of the pituitary gland. They present with headaches, visual disorders, or cranial nerve deficits. NFPAs can recur, progress, or present as residual tumors. We, therefore, conducted this review to compare the effects of both revision surgery and stereotactic surgery on tumor size, visual status, endocrine status, and complications.

Methods:

A systematic review of published literature on recurrent, residual, or progressing NFPAs that underwent redo surgery or stereotactic radiosurgery from the inception till June 2020 was conducted as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Thirteen records (1209 patients) were included, and risk ratio (RR) and 95% confidence intervals (CIs) estimated from each study were pooled using a random-effects meta-analysis model.

Results:

Redo surgery was the preferred intervention in patients presenting with larger tumor sizes and was more effective in reducing the tumor size as compared to stereotactic radiosurgery (SRS) (risk ratio [RR] 56.14; 95% CI, 16.45–191.58). There was more visual loss with revision surgery as compared to SRS (risk ratio [RR] 0.08; 95% CI, 0.03–0.20). However, SRS was associated with fewer complications, such as new diabetes insipidus, as compared to the redo surgery (risk ratio [RR] 0.01; 95% CI 0.01–0.03).

Conclusion:

Redo surgery is the superior choice in the treatment of recurrent/residual or progressing NFPAs if the tumor size is large and an immediate reduction in tumor burden through debulking is warranted. However, redo surgery is associated with a higher risk of visual loss, new endocrinopathies, and other complications, in contrast to SRS.
Massive bilateral paraclinoidal subdural empyema and parenchymal temporopolar abscess with anatomical infection pathway in a chronic inhaling cocaine-addicted patient: A case report and literature review
Authors: Corazzelli Giuseppe , Corvino Sergio , Noto Giulio Di , Germano Cristiana , Buonamassa Simona , Colandrea Salvatore Di , Falco Raffaele de , Bocchetti Antonio
Published: February 2024

Background:

Focal suppurative bacterial infections of the central nervous system (CNS), such as subdural empyemas and brain abscesses, can occur when bacteria enter the CNS through sinus fractures, head injuries, surgical treatment, or hematogenous spreading. Chronic cocaine inhalation abuse has been linked to intracranial focal suppurative bacterial infections, which can affect neural and meningeal structures.

Case Description:

We present the case of a patient who developed a cocaine-induced midline destructive lesion, a vast bilateral paraclinoidal subdural empyema, and intracerebral right temporopolar abscess due to cocaine inhalation abuse. The infection disseminated from the nasal and paranasal cavities to the intracranial compartment, highlighting a unique anatomical pathway.

Conclusion:

The treatment involved an endoscopic endonasal approach, followed by a right frontal-temporal approach to obtain tissue samples for bacterial analysis and surgical debridement of the suppurative process. Targeted antibiotic therapy helped restore the patient’s neurological status.
Działalność Związku Młodzieży Polskiej Pochodzenia Żydowskiego „Żagiew” w Łodzi w latach I wojny światowej (1914–1918)
Authors: Stawiszyńska Aneta
Published: February 2024

Przez kilka lat na terenie Łodzi działał Związek Młodzieży Polskiego Pochodzenia Żydowskiego „Żagiew”, skupiający młodzież żydowską. Organizacja reprezentowała kierunek asymilatorski. W czasie Wielkiej Wojny członkowie organizacji aktywnie angażowali się w działania związane z kwestią polską, na przykład w obchody rocznic polskich. „Żagiew”, zarówno w czasie wojny, jak i po jej zakończeniu, widziała rozwiązanie kwestii żydowskiej w niepodległym państwie polskim, a także dyskutowali z organizacjami syjonistycznymi, które dążyły do osiedlenia się mniejszości żydowskiej poza Polską. Organizacja „Żagwi” w Łodzi nie miała jednak zbyt dużego wpływu na żydowskie środowisko młodzieżowe.
СТРОЕНИЕ ЗАПАДНОЙ КАМЧАТКИ НА ПРИМЕРЕ РЕЗУЛЬТАТОВ ГЛУБИННЫХ ИССЛЕДОВАНИЙ ВДОЛЬ ПРОФИЛЯ С. ХАЙРЮЗОВО - С. КРАПИВНОЕ
Authors: Нурмухамедов А.Г. , Сидоров М.Д. , Трухин Ю.П.
Published: February 2024

В статье представлены результаты глубинных исследований вдоль профиля с. Хайрюзово - с. Крапивное, пересекающего в юго-восточном направлении Западную Камчатку. На основе комплексной интерпретации геолого-геофизических данных построена модель строения земной коры и верхней мантии, в которой выделены основные разделы литосферы: граница Мохоровичича, отделяющая земную кору от верхней мантии; граница, разделяющая земную кору на нижний гранулито-базитовый и верхний гранито-метаморфический слои; граница, отождествляемая с кровлей консолидированной коры - кристаллического фундамента и другие границы. Показаны ранее неизвестные элементы строения земной коры, такие как система наклонных разрывных нарушений, образующих под Паланской впадиной сквозькоровую ослабленную зону, по которой проникал мощный тепловой поток в верхнюю кору; в основании прогиба выделен слой пород предположительно основного состава, по смещению которого амплитуда сброса составляет не менее 4 км. Земная кора отнесена к коре континентального типа. В центральной части модели выделена ослабленная зона - предполагаемая область питания вулканов Центрально-Камчатского вулканического пояса. Проницаемая зона сформирована на участке максимального перегиба (палеослэба) субдуцирующей в геологическом прошлом океанической литосферы. Ограниченный в пространстве наклонный объект, выделенный в вулканогенно-осадочной толще пород Паланской впадины не является частью Срединно-Камчатского аллохтонного террейна. Но близость значений плотности, магнитной восприимчивости, толщины сопоставляемых ксеноблоков даёт основание предполагать, что наклонный объект может быть отдельным фрагментом архипелага островной дуги, причленившейся к Палеокамчатке в раннем эоцене. Наклон объекта сформировался в более позднее время в результате образования сброса юго-восточного крыла впадины.
РАЗРАБОТКА КЛАССИФИКАЦИИ РЕМЕННЫХ И ТРОСОВЫХ ПРИВОДОВ МЕХАНИЗМОВ ДЛЯ ПРОСТРАНСТВЕННЫХ ДВИЖЕНИЙ
Authors: Борисов В.А.
Published: February 2024

Приводится классификация ременных и тросовых приводов механизмов для реализации пространственных движений. Выделяются ключевые классификационные признаки, приводятся примеры и описываются различные механизмы, в которых реализованы рассматриваемые примеры для ременных и тросовых приводов. Приводятся выводы и рекомендации по дальнейшему развитию разработанной классификации.
Efficient large-scale exploration of fragment hit progression by exploiting binding-site purification of actives (B-SPA) through combining multi-step array synthesis and HT crystallography.
Authors: Grosjean Harold , Aimon Anthony , Hassell-Hart Storm , Thompson Warren , Koekemoer Lizbé , Bennett James , Anderson Cameron , Wild Conor , Bradshaw William , FitzGerald Edward A , Krojer Tobias , Bradley Anthony , Fedorov Oleg , Biggin Philip C. , Spencer John , von Delft Frank
Published: February 2024

Fragment approaches are long-established in target-based ligand discovery. Nevertheless, their full transformative potential lies dormant, because progressing hits to potency remains difficult and underserved by methodology developments, which mostly focus on screening. The only credible progression paradigm is conventional design-make-test analyse (DMTA) medicinal chemistry, which is costly and thus necessitates picking winners early, thereby effectively discarding all the other hits. We here demonstrate the workability of an alternative strategy, namely immediate large-scale exploration of diverse hit-inspired compounds. The key insight is that it is effective to cheaply parallelize large numbers of non-uniform multi-step reactions, because even without compound purification, a high-quality readout of binding is available, namely crystallography of fragment screening. This has the sensitivity to detect even low-level binding of slightly active compounds, which the targeted binding site extracts directly from crude reaction mixtures (CRMs). In this proof-of-concept study, we expand a fragment hit from a crystal-based screen of the second bromodomain of human PHIP, using array synthesis on low-cost robotics to implement 6 independent multi-step reaction routes of up to 5 steps, attempting the synthesis of 1876 diverse expansions; designs were entirely driven by synthetic tractability. Expected product was present in 1108 CRMs, as detected by automated mass spectrometry; and 22 individual products were resolved in crystal structures of CRMs added to crystals. These provided an initial SAR map, revealed pose stability in 19 and instability in 3 products, and resolved stereochemical preference. Unexpectedly, in view of the naïve design approach, one resolved compound even showed on-scale biochemical potency (IC50=34 μM) and biophysical affinity (Kd=50 μM) after resynthesis. This binding-site purification of actives (B-SPA) process is formulaic and engineerable, here yielding the output of >25 person-years in ~20 days, with solvent use reduced from >4,500L to <20L. Thus, this approach, coupled with algorithmically guided compound and reaction design and new formalisms for data analysis, lends itself to routine fragment progression.
Elucidating the lithiation process in Fe3–δO4 nanoparticles by correlating magnetic and structural properties
Authors: Ulusoy Seda , Feygenson Mikhail , Thersleff Thomas , Uusimäki Toni , Valvo Mario , Gomez Roca Alejandro , Nogues Josep , Svedlindh Peter , Salazar-Alvarez German
Published: February 2024

Due to their high potential energy storage magnetite (Fe3O4) nanoparticles have become appealing for anode materials in lithium-ion batteries. However, the details of the lithiation process are still not completely understood. Here, we investigate chem- ical lithiation in 70 nm cubic shaped magnetite nanoparticles with varying degree of lithiation x = 0, 0.5, 1, 1.5. The induced changes on the structural and magnetic properties were investigated by using X-ray techniques along with electron microscopy and magnetic measurements. The results indicate that a structural transformation from spinel to rock salt phase occurs above a critical limit for the lithium concentra- tion (xc), which is determined to be between 0.5< xc≤1 for Fe3–δO4. Magnetization measurements clearly shows the formation of the LiFeO2 phase with its distinct anti- ferromagnetic behaviour below its Need temperature. Upon lithiation, magnetization measurements reveal exchange bias in the hysteresis loops with an asymmetry, which can be attributed to the formation of mosaic-like LiFeO2 subdomains. The combined characterization techniques enabled us to unambiguously identify the phases and their distribution involved in the lithiation process. Correlating magnetic and structural properties opens the path to increase the understanding of the processes involved in a variety of non-magnetic applications of magnetic materials.
Uncovering the Impact of Spectroscopic Data Reduction Techniques on the Process Control Mode Pattern Recognition: The Case of Industrial Penicillin Production
Authors: vishakha vishakha , Jancar Josef
Published: February 2024

Process Analytical Technologies (PAT) often rely on real-time spectroscopy, allowing for fast-paced process control and monitoring. However, the data generated from real-time spectroscopy for long-running process systems can result in excessively large databases, which can be challenging to manage and may not necessarily lead to better process control. Therefore, it is crucial to reduce the amount of data generated by real-time spectroscopy while still retaining the essential information needed for process control. This work explores various data reduction techniques to address this issue. IndPenSim, a simulated spectroscopic probing dataset, was used as an oracle model to study the impact of data reduction techniques on the resulting process control identification. For analysis, the data pipeline consists of using principal component analysis (PCA) for visualization, followed by truncation and pre-processing (e.g. baseline corrections). Moreover, we have discussed the impact of data size reduction techniques (e.g. spectral data column selection, data binning, and region of interest (ROI), etc.) on the different chemometric models (e.g. PCA, PLS-DA, SIMCA, and KNN, etc.). Finally, the study examined the impact of data reduction on the control strategy for a realistic industrial fed-batch penicillin simulator. The multi-class classification performance was analyzed, and the results were interpreted to determine the best approach for controlling the process. Overall, the study provides valuable insights into data reduction techniques for real-time spectroscopy in PAT, which can improve the efficiency and accuracy of process control and monitoring.
C(sp3)–H sulfinylation of light hydrocarbons with sulfur dioxide via hydrogen atom transfer photocatalysis in flow
Authors: Nagornîi Dmitrii , Raymenants Fabian , Kaplaneris Nikolaos , Noel Timothy
Published: February 2024

Sulfur-containing scaffolds originating from small alkyl fragments play a crucial role in various pharmaceuticals, agrochemicals, and materials. Nonetheless, their synthesis using conventional methods presents significant challenges. In this study, we introduce a practical and efficient approach that harnesses hydrogen atom transfer photocatalysis to activate volatile alkanes, such as isobutane, butane, propane, ethane, and methane. Subsequently, these nucleophilic radicals react with SO2 to yield the corresponding sulfinates. These sulfinates then serve as versatile building blocks for the synthesis of diverse sulfur-containing organic compounds, including sulfones, sulfonamides, and sulfonate esters. Our use of flow technology offers a robust, safe and scalable platform for effectively activating these challenging gaseous alkanes, facilitating their transformation into valuable sulfinates.
Sulfur(VI) Fluoride Exchange Chemistry in Solid-Phase Synthesis of Compound Arrays: Discovery of Histone Deacetylase Inhibitors
Authors: Hansen Tobias N. , Dankova Daniela , Bæk Michael , Grlas Linda , Olsen Christian Adam
Published: February 2024

Multistep synthesis performed on solid support is a powerful means to generate small molecule libraries for the discovery of chemical probes to dissect biological mechanisms as well as for drug discovery. Therefore, expansion of the collection of robust chemical transformations amenable to solid-phase synthesis is desirable for achieving chemically diverse libraries for biological testing. Here we show that sulfur(VI) fluoride ex-change (SuFEx) chemistry, exemplified by pairing phenols with aryl fluorosulfates, can be used for solid-phase synthesis of biologically active compounds. As a case study, we designed and synthesized a library of 84 hy-droxamic acid containing small molecules, providing a rich source of inhibitors with diverse selectivity pro-files across the human histone deacetylase enzyme family, which is a validated drug target. Among other dis-coveries, we identified a scaffold that furnished inhibitors of HDAC11 with exquisite selectivity in vitro and a selective inhibitor of HDAC6 that was shown to bind this target enzyme selectively over HDAC8 in cells, using cellular thermal shift assays (CETSA). Our results encourage the further use of SuFEx chemistry for the syn-thesis of diverse small molecule libraries, provides insight for future design of selective HDAC inhibitors, and show that CETSA can be applied for evaluation of cellular target engagement of HDAC inhibitors.
Breaking Cycles: Saponification-Enhanced NMR Fingerprint Matching for the Identification and Stereochemical evaluation of cyclic lipodepsipeptides from natural sources
Authors: Muangkaew Penthip , Prasad Durga , De roo Vic , Verleysen Yentl , De Mot René , Höfte Monica , Madder Annemieke , Geudens Niels , Martins José
Published: February 2024

We previously described NMR based fingerprint matching using peptide backbone (CHα) resonances as a fast and reliable way to perform structural dereplication of Pseudomonas cyclic lipodepsipeptides (CLiPs). In addition, its combination with total synthesis of a small library of CLiPs was shown to afford unambiguous determination of the stereochemistry, further opening these compounds for structure-activity relationship studies and three-dimensional structure determination. However, the need to include on-resin macrocycle formation in the synthetic workflow results in considerable burden and limits universal applicability to CLiPs. Here we show that this drawback can be removed by first converting the native CLiP of interest into its linearized analogue via controlled hydrolysis of the depsi bond through saponification. By avoiding the macrocycle formation altogether, the required synthesis effort is strongly reduced as it now only requires production of linear peptide analogues. The NMR fingerprints of the linear peptide analogues display a sufficiently distinctive chemical shift fingerprint to act as effective discriminators. The approach is developed using viscosin group CLiPs and subsequently demonstrated on putisolvin, leading to a structural revision, and tanniamide, a newly isolated compound defining a new group in the Pseudomonas CLiP portfolio. These examples demonstrate the effectiveness of the saponification- enhanced approach that broadens applicability of NMR fingerprint matching for the determination of the stereochemistry of CLiPs.
Infection from Omicron Sub-Lineages
Authors: Shankar P.S.
Published: February 2024

None
Detection of β-lactamases among Multi-drug Resistant Enterobacteriaceae Colonising Gut of Normal Adults and Patient Population
Authors: P Nambiar Amritha , Antony Beena
Published: February 2024

Background and aims Antibiotic resistance is a growing threat in the medical field and the Enterobacteriaceae leading commensals in the gut are more likely to develop resistance. In this study we aimed to compare the anti-microbial resistance pattern with a special reference to beta-lactamase producers in Escherichia coli and Klebsiella pneumoniae as normal flora and pathogens.Methods A total of 120 bacterial strains of E. coli and Klebsiella were tested for antibiotic sensitivity by Kirby Bauer Disk diffusion method. Multi-drug resistant MDR bacteria were identified and phenotypically classified based on beta lactamase production into ESBL Extended Spectrum beta Lactamase AmpC beta Lactamase and MBL Metallo beta Lactamase respectively.Results Ampicillin resistance was the highest in both categories showing rates of 34 56 and 50 83.3 in normal and pathogenic strains respectively. Cefotaxime was a close second with resistance rates of 25 41.6 and 37 61.6. Imipenem showed the lowest resistance rates of 7 11.6 and 4 6.60 in normal and pathogenic strains. Pathogenic and normal strains showed an MDR rate of 51.6 and 40.5 respectively. ESBL production was observed in 1.6 P 41.6 N AmpC was 31.6 P 20 N and MBL was detected in 25 P 16.6 N.Conclusion The study revealed an alarming rate of beta lactamase-producing MDR commensals in the region. The narrow gap between the hospitalized and healthy individuals in resistance rates was a proof of rapid transmission of resistance genes signifying the need for screening even the normal population for antibiotic resistance patterns.
Are the Benefits of Emergency Remote Education Truly Benefits? Ethical Dilemmas and Research Results on Emergency Remote Education from the Perspective of Prospective Teachers and the Foundations of Pedagogical Study Programmes
Authors: Krek Janez , Hodnik Tatjana , Vogrinc Janez
Published: February 2024

Commencing in March 2020 and continuing during the 2020/2021 academic year, all university education was forced to introduce emergency remote education due to restrictions imposed in countries affected by the Covid-19 pandemic. In the present empirical study, which includes a representative sample of students from one of the education faculties in Slovenia, data was obtained on the conditions and implementation of study programmes via emergency remote education. The areas of study were the material conditions for studying, the pedagogical process in emergency remote education, the ethics of the rules of performance and assessment, and the academic community. The study provides an analysis of the changes that took place in the implementation of the pedagogical process during emergency remote education from the students’ perspective and an examination of the extent to which it provided equal opportunities for students. The results show that the success of students in their studies depends on technical conditions and the environment; that rapid transitions from one type of studying to another (from emergency remote education to hybrid or entirely at the faculty) are not recommended; that the teaching process was based on the concept of face-to-face teaching, partly adapting to different conditions on this basis; and finally, that the “desire for comfort” entered into the assessment of the quality and fairness of the educational process. Based on the values of our professional ethical judgement and the results of the study, we conclude that higher education teachers should be aware that providing comfort to some students who have the appropriate conditions for studying or simply preferring to teach from the comfort of home are not adequate reasons to maintain online delivery of courses compared to the criteria of justice and quality in education.
Industrial Struggle: New Directions in Social Research
Authors: Frenkel Stephen J. , Coolican Alice
Published: February 2024

Studies of labour struggle span a wide range of analytical and methodological standpoints. At one extreme one finds quantitative modelling of strike behaviour while at the other there are the sociological accounts of specific incidents of conflict. Clearly, the choice of research strategy and methodology depend upon the issues addressed and the disciplinary context from which such questions emerge. Our concern is to understand and explain variations in inter-industry patterns of industrial action. By working at an intermediate level of analysis we hope to steer between the Scylla of extreme abstraction (evidenced by mcst national level strike studies) and the Charybdis of interpretive empiricism (exemplified by many plant level case studies of strikes).
Grievance Arbitration and Conflict Regulation
Authors: Turkington Don J.
Published: February 2024

Industrial conflict, when viewed as an incompatibility of objectives in forming or operating the employment relationship, is a common occurence which can take many forms. Some are initiated by individual workers, others by groups of workers and yet others by the employer. Despite this diversity, much of the effort to regulate conflict centres on only one form, namely, the strike. Very often it consists of providing alternatives to the strike. An extreme example is New Zealand where legislation has provided conciliation and arbitration and prohibited strikes. In the United States, the parties to most private sector labour contracts have specified a grievance procedure, capped by arbitration, intended to take the place of the strike in conflicts over "rights".
President's Annual Report 1979
Authors: Tuxford Ken
Published: February 2024

With the now well established annual ritual of new, deleted or amended Industrial Relations legislation, it would seem that the area of Industral Relations has become a legislative paradise! Perhaps in the future, when we hear or read about the 99th amendment to some particular item of Industrial legislation, we shall probably have become so immune to the changes that our only response will be to give a deep yawn!
Chronicle: October 1979 - March 1980
Authors: Roth Bert
Published: February 2024

Chronicle covering October 1979 to March 1980.
The Uniform of Women’s Gymnasium Employees in the Vision of the Heads of Institutions in Kyiv Educational District (late 19th — early 20th century)
Authors: Drach Oksana
Published: February 2024

Modern-day clothing is an all-encompassing marker of social identities. We deepen the usual political economic and socio-demographic analysis of Ukrainian society with a cultural one, which acquires a significant mobilizing resource. The source base of the study is the materials of clerical correspondence of the trustee of Kyiv educational district with the heads of women’s educational institutions and the Heads of the Pedagogical Councils of the female gymnasiums and pro-gymnasiums of the Ministry of National Education regarding the introduction of uniforms for women who worked in women’s secondary education institutions. The hermeneutic method and the constructivist tradition of discourse analysis, as well as the latest approaches of Western feminist theory, were identified as research methods for the implementation of research tasks. Gender-specific experience should become an integral part of historical knowledge. The opinions of heads of women’s educational institutions of the Kyiv educational district regarding the introduction of uniforms for their female employees were studied. It was established that the absolute majority (95.65 %) of managers supported the proposal, as well as the fact of wearing uniforms by staff in some female gymnasiums without sanction from above. Self-affirmation of female teachers in the service took place through fashionable clothes, which contrasted with their small salary. Self-affirmation of female teachers in the service took place through fashionable clothes, which contrasted with their small salary. The latent dissatisfaction of the bosses with the fashion of female educators in institutions was revealed. It is substantiated that the “highly desirable / useful” introduction of uniforms to female educators was caused by individual and group level factors. The socio-economic and corporate-ethical motives of the chiefs prove the difficult gender relations in the teaching teams, which the uniform of female employees of gymnasiums and pro-gymnasiums had to correct. The recommended uniforms of female educators provided for the functional parameters of its cut, the minimization of decorative details and, most importantly, the dark blue color of the fabric.
Data analysis in the study of the world economy. Issue 5
Authors: Chernyak Vladimir
Published: February 2024

This publication contains the papers of participants of the seminar “Data Analysis in the International Economy.” They are focused on the analysis of the data on the global economy. As presented in the papers, such data can be processed by various methods, including the methods of statistics, econometrics and machine learning. This is the fifth collection of student’s papers (the first was published in 2018, the fourth in 2022). The main feature of the new collection is the deep interest of the authors in modern methods of data analysis, now these methods, along with econometrics, are taught to students on a regular basis. The book can be used as a supplement to economics and econometrics courses on international economics, as well as an auxiliary material for preparing a master's thesis in this field.
Capacidades dinámicas en las mipymes para la adaptabilidad de la industria 4.0
Authors: Silva-Casas Rosalía , Estrada-Domínguez Jesús Eduardo
Published: February 2024

Las pymes enfrentan un gran desafío con la cuarta revo- lución industrial pues están en camino al desarrollo de estrategias de producción y mejorar sus procesos, a esto se suma la búsqueda de talento del capital humano. El de- safío también corresponde a la educación en ingeniería, se requiere fortalecer y desarrollar competencias digita- les en los estudiantes, para hacer frente a los cambios tec- nológicos de la industria 4.0. La presente investigación aborda las necesidades digitales en las pymes para tradu- cirlas en capacidades educativas requeridas de los futuros egresados de ingenierías que podrán ayudar a la forma- ción de ingenieros 4.0 capaces de abordar esta revolución industrial ya que los requisitos serán más complejos y específicos. El avance tecnológico y el crecimiento de in- versión en nuestro país reafirman la idea de que se necesi- tan desarrollar capacidades digitales como computación de la nube, internet de las cosas y manufactura aditiva para satisfacer la futura demanda de la industria
Intense Pulsed Light (IPL) therapy in acne vulgaris management: Assessing efficacy and safety.
Authors: Aqsa Naheed  , Tehseen Naveed  , Marwa Samee  , Muhammad Moeez Badar  , Quratulain Ejaz  , Moazama Afzal
Published: February 2024

Objective: To evaluate efficacy and safety of IPL in the treatment of Acne vulgaris. Study Design: Quasi-experimental study. Setting: CMH, Peshawar. Period: 15th January 23 to 15th May 23. Material & Methods: 35 participants having acne vulgaris with age range from 18-35 years were selected. Participants who had used any form of topical, oral, or alternative treatments for acne, including retinoids, within the six months preceding the commencement of the study, history of systemic steroid intake, photosensitivity and herpes simplex, were excluded. Global Acne Grading System (GAGS) score was used to ascertain the severity of acne vulgaris. Four sessions of weekly Intense Pulsed Light (IPL) sessions, utilizing filters of 420nm, 510nm and 560nm for participants having skin type III, IV and V respectively were employed. GAGS score was calculated one week after the last session. Side effects were recorded, degree of improvement and patient reported outcome was noted using a four-point scale limited =<25%, marked =25%-50%, promising 50-75% and profound =>75%. Results: Mean age of participants was 21.63 ± 4.63 years, with a mean duration of acne was 4.26 ± 2.20 years. The mean baseline GAGS score I decreased from 22.00±5.26 to 11.58±4.80, as observed one week following the last IPL session. The calculated p-value was statistically significant (<0.000). 54% of patients encountered no adverse reactions. Conclusion: Intense Pulsed Light (IPL) emerges as a secure and efficacious treatment choice, particularly in the initial stages, to enhance the response to therapy.
Dyslipidemia: A risk factor for cataract.
Authors: Yasir Iqbal  , Aqsa Malik  , Masooma Talib  , Iqra Anwar  , Sohail Zia  , Usman Arshad Qureshi
Published: February 2024

Objective: To determine lipid profile in patients of age-related cataract and compared them with age-matched controls. Study Design: Case Control study. Setting: Naseer Memorial Hospital, Dadyal. Period: January 2022 to December 2022. Material & Methods: A total of 300 patients were recruited using a consecutive non-probability sampling method and divided in two groups, one control and the other having cataract. The patients underwent a thorough ocular assessment and lipid profile evaluation. Inclusion criteria was age 40 years or older of any gender having senile cataracts of any morphological form. Exclusion criteria was history of ocular trauma, systemic disease, ocular surgery, oral steroids or cataract other than senile cause. The data was analyzed using SPSS version 23. The results showed that patients with senile cataracts had significantly higher levels of total cholesterol, triglycerides, and LDL cholesterol, and significantly lower levels of HDL cholesterol than the controls. The collected data was entered in the statistical package for social sciences (SPSS) version 21 for analysis. Independent t test was applied and p value ≤ 0.05 was considered as significant. Results: It was found that patients with senile cataracts had significantly higher levels of total cholesterol, triglycerides and LDL and significantly lower levels of HDL than the age-matched controls. Conclusion: The findings suggested that dyslipidemia is a modifiable risk factor for age-related cataract.
RELATO DE EXPERIÊNCIA NO PIBID: A INTERDISCIPLINARIDADE NA PRÁTICA DOCENTE
Authors: Soares Ana Flávia Nogueira , Santos Darllyeth Alves dos , Batista Ruth Alves , Rocha Tayná Marques da , Matos Bruno Sérvulo da Silva
Published: February 2024

O seguinte estudo pretende evidenciar de que maneira a aplicação da Interdisciplinaridade na prática docente pode enriquecer o processo educativo. Para isso, passamos por um longo período de planejamento, com reuniões e pesquisas dentro do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) até chegar à realização de uma oficina sobre Educação Financeira, utilizando aspectos tanto da Língua Portuguesa como da Matemática com o apoio da Sequência Básica de Rildo Cosson (2009), que foi essencial para a construção das etapas de cada aula. Conseguimos, então, relacionar o uso do gênero notícia e alguns problemas matemáticos para trabalhar a temática do Planejamento Financeiro, de forma que levamos os alunos a refletir sobre o uso do dinheiro no contexto em que está inserido. Concluímos que a Educação Financeira precisa estar presente desde a educação básica e que é possível fazer isso a partir da interdisciplinaridade entre Língua Portuguesa e Matemática.
AUDIÊNCIA DE CUSTÓDIA E A NATUREZA DA PRISÃO: CONSIDERAÇÕES PONTUAIS NO ÂMBITO NACIONAL E ESTADUAL
Authors: Elias Marcus Vinicius de Oliveira , Lima Milena Moraes
Published: February 2024

Trata dos textos legais internacionais, nacionais e regionais embasadores da audiência de custódia, como forma de preservar a integridade física e psíquica dos que se encontrem cautelarmente custodiados pelo Estado. Adotou-se o método descritivo e exploratório quanto ao objetivo, qualitativo quanto à abordagem, e bibliográfico quanto ao procedimento, cuja base teórica calca-se na literatura especializada sobre o tema. Como resultado, verificou-se que o Brasil, por meio da audiência de custódia, tendo como norte os Pactos Internacionais, a Constituição Federal, o Pacote Anticrime, as Resoluções do Conselho Nacional de Justiça e os Provimentos do Tribunal de Justiça do Estado de Mato Grosso do Sul, propiciou aos custodiados cautelarmente um tratamento mais próximo da dignidade da pessoa humana, pois são vistos como sujeitos de direitos. No entanto, mesmo após o reconhecimento normativo, há um longo caminho a ser percorrido pelo Estado até a efetivação da audiência de custódia, pois são diversos os obstáculos enfrentados no dia a dia para concretização dos direitos legalmente previstos. Há necessidade de adequação dos mecanismos práticos estatais, qualificação dos servidores e disponibilização dos meios materiais para tanto. Quanto à ampliação das prisões às quais é aplicada a audiência, verificou-se uma sucessiva edição de atos normativos sobrepostos, visando efetivar sua realização, mas também adequar as previsões legais à realidade prática do dia a dia. No entanto, há necessidade de atualização das normativas, alinhando a prática forense ao que foi decidido pelo STF na Reclamação 29303, bem como de investimentos no aparato estatal para viabilização da aplicabilidade de tais normas.
DISPENSA DE LICITAÇÃO IMPLEMENTADA PELA LEI N. 14.133/2021 NO MATO GROSSO DO SUL
Authors: Deliberaes Maria Fernanda Ferraz , Botelho Tiago Resende , Farinelli Alisson Henrique do Prado
Published: February 2024

O objetivo deste artigo é a análise das dificuldades enfrentadas pelas Administrações Públicas na implementação da dispensa de licitação instituída pela Nova Lei de Licitações, a Lei Federal n. 14.133/21, a qual trouxe inovações que buscam a prevalência do meio eletrônico no âmbito das contratações públicas. Inicialmente supõe-se que os obstáculos podem estar relacionados a ausência de pessoal qualificado ou devidamente capacitado para aplicação dos novos procedimentos. O presente estudo analisa as diferenças entre este novo modo e os procedimentos anteriores, bem como a exposição dos pontos positivos e negativos da alteração legislativa, com enfoque na atuação de municípios de grande e pequeno porte pertencentes ao Estado de Mato Grosso do Sul. Para isso, foi realizada uma pesquisa qualitativa com representantes dos departamentos de licitação desta Unidade Federativa e das cidades de Dourados, Ivinhema, Juti e Japorã. Adotou-se na pesquisa o método hipotético-dedutivo, com utilização de livros, artigos e obras que versam a respeito do tema. A partir das análises empreendidas foi possível observar que as dificuldades estão relacionadas, principalmente, a insuficiência de governança pública.
DEMARCAÇÃO DAS TERRAS INDIGENAS. EXIGÊNCIA DA PRSENÇA DO MARCO TEMPORAL (ART. 4º DA LEI 14.701/2023): INCONSTITUCIONALIDADE E INCONVENCIONALIDADE. VIOLAÇÃO AOS ARTS. 60 E 231 DA CONSTITUIÇÃO DA REPÚBLICA. AGRESSÃO DO NÚCLEO ESSENCIAL DO DIREITO GARANTIDO PELO PODER CONSTITUINTE ORIGINÁRIO E AO PRINCÍPIO PROIBITIVO DO RETROCESSO SOCIAL
Authors: Lima Filho Francisco das C.
Published: February 2024

O artigo faz uma análise da exigência do “marco temporal” como condição ou exigência para demarcação das terras indígenas, declarado inconstitucional pelo Supremo Tribunal Federal no julgamento do RE 1017365, com repercussão geral (Tema 1.031), e que foi criado pela Lei 14.701/2023 (art. 4º), em violação à Carta Suprema (arts. 60 e 231), à Declaração Universal dos Direitos dos Povos Indígenas e Tribais da Organização das Nações Unidas - UNU, além do contido na Convenção 169 da Organização Internacional do Trabalho – OIT.
A VERDADEIRA FILOSOFIA EMPREGADA NO ATUAL DIREITO INTERNACIONAL HUMANITÁRIO
Authors: Vescovi Luiz Fernando
Published: February 2024

O presente ensaio tem por propósito expor as diferentes facetas filosóficas que giram em torno da moderna atividade humanitária internacional, que se apresentam para além das vertentes tradicionais. A pesquisa se presta, ainda, para aclarar os elementos de cunho histórico, conceitual e finalístico do Direito Internacional Humanitário, de forma a compreender o modus operandi dos principais grupos que atuam nesse segmento. Por conseguinte, pretende-se elucidar as novas intenções ideológicas que estão sendo postas (e/ou implantadas) no contexto das causas humanitárias supranacionais, que exprimem a mudança da estrutura clássica deste ramo às aspirações de natureza política e econômica que certos Estados impõem, para que as organizações possam operar humanitariamente dentro de seus espaços territoriais, ademais dos próprios desígnios e interesses que cada grupo deste gênero demonstra.
DEMOCRACIA E ALGORITMOS: A MODULAÇÃO DA AUTODETERMINAÇÃO POLÍTICA NO PROCESSO ELEITORAL BRASILEIRO
Authors: Carneiro Gabriel de Oliveira , Brígido Edimar Inocêncio
Published: February 2024

Este artigo analisa as interações multifatoriais entre tecnologia e política nas eleições de 2022 no Brasil, investigando de que modo e em qual medida os algoritmos reverberam no processo eleitoral, lançando mão de obras, notícias e pesquisas e, num segundo momento, efetuando uma análise qualitativa de dados jurisprudenciais relativos às eleições de 2022. Em um contexto de polarização política e influência das mídias digitais, este estudo examina como o uso de algoritmos redefiniu o processo eleitoral, impactando a formação de opinião dos eleitores e o ambiente político. Além disso, explora-se a responsabilidade das grandes empresas de tecnologia na disseminação de informações enganosas e no direcionamento de conteúdo político. Então, examinar-se-á a jurisprudência do Supremo Tribunal Federal e do Tribunal Superior Eleitoral relacionada às eleições de 2022, investigando-se a intersecção entre algoritmos e democracia para fins de responsabilização jurídica, destacando-se a inexpressiva responsabilização para big techs que recai, em realidade, sobre os usuários no que tange à disseminação de notícias falsas, aplicando-se multas ou suspensões de conteúdo. As descobertas destacam, ainda, a emergência de uma esfera pública digital dominada por big techs, em que dados pessoais se tornaram valiosas commodities operadas por algoritmos personalizados, cujo potencial de influenciar o comportamento dos eleitores levanta preocupações sobre transparência e manipulação política.
In vivo anti-inflammatory activity of the essential oil of zingiber officinale rhizomes on Wistar rats
Authors: Djelassem Ferdinand  , Mbida Hacheked  , Aboubakar Sidiki  , Nnanga Nga  , David  Emery Tsala
Published: February 2024

Background: Zingiber officinale is a spice consumed in Chad and traditionally used against osteoarthritis, migraine and rheumatic pain, but few pharmacological studies of this plant have been carried out. The aim of this study was to assess the in vivo anti-inflammatory activity of Z. officinale rhizomes essential oil (EO). Methods: A preliminary phytochemical screening was carried out on the EO of Z. officinale rhizomes; the anti-inflammatory activity of the given plant extract was then assessed at the concentrations of 0.20%, 1% and 5% on three experimental models: egg yolk-induced oedema, cotton pellet-induced granuloma and formalin. In addition, the essential oil was tested for its in vitro antioxidant capacity using the 2,2-Diphényl-2-picryl-hydrazyle Free Radical Scavenging Test, acide 2,2'-azino-bis 3éthylbenz- thiazoline-6-sulfonique Radical Test and the Ferric reducing antioxidant power Test. The study was extended to the acute toxicity of the EO of the rhizomes of Z. officinale using the sequential method. Results: Qualitative phytochemical screening of the EO of Z. officinale rhizome revealed the presence of tannins, flavonoids, triterpenes, terpenoids and free quinones. In the egg yolk-induced edema model, the EO of Z .officinale rhizomes significantly inhibited (p < 0.01) oedema by 25.28%, 31.12% and 68.27% at the concentrations of 0.20%, 1% and 5%, respectively, when compared to controls. In the formalin-induced paw edema model, EO of Z. officinale rhizomes inhibited oedema by 24.27%, 30.14% and 43.14% at the concentrations of 0.20%, 1% and 5%, respectively, when compared to the controls. In the cotton pellet-induced granuloma model, EO of Z. officinale rhizomes induced an anti-granulomatous effect of 32.68%, 38.27% and 41.51% at the concentrations of 0.20%, 1% and 5%, respectively, as compared to controls. Additionally, the EO of the rhizomes of Z. officinale also induced in vitro antioxidant and free radical scavenging activity and iron reduction. Definitely, the LD50 of the EO of Z. officinale rhizomes was estimated as more than 2000 mg/kg b.w. Conclusion: The EO of Z. officinale rhizomes exhibited anti-inflammatory activity. This effect can be explained, at least partly to its chemical content and its antioxidant potential.