bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent advances and challenges of bispecific antibodies in solid tumors
Authors: Wu Yuze , Yi Ming , Zhu Shuangli , Wang Haiyong , Wu Kongming
Published: December 2021

Cancer immunotherapy has made remarkable progress in the past decade. Bispecific antibodies (BsAbs) have acquired much attention as the next generation strategy of antibody-target cancer immunotherapy, which overwhelmingly focus on T cell recruitment and dual receptors blockade. So far, BsAb drugs have been proved clinically effective and approved for the treatment of hematologic malignancies, but no BsAb have been approved in solid tumors. Numerous designed BsAb drugs for solid tumors are now undergoing evaluation in clinical trials. In this review, we will introduce the formats of bispecific antibodies, and then update the latest preclinical studies and clinical trials in solid tumors of BsAbs targeting EpCAM, CEA, PMSA, ErbB family, and so on. Finally, we discuss the BsAb-related adverse effects and the alternative strategy for future study.
The perception of the leader as an attachment figure: can it mediate the relationship between work engagement and general/citizenship performance?
Authors: Lisá Elena , Greškovičová Katarína , Krizova Katarina
Published: December 2021

The study aimed to explore the perception of the leader as a security provider as a potential mediator of the relationship between work engagement and perceived general and citizenship work performance. Five hundred and forty-two adults completed the Leader as a security provider scale, Utrecht work engagement scale, General work performance questionnaire, and Citizenship organizational behavior questionnaire to self-report on their organizational behaviors. The perception of the leader as a secure attachment figure partially mediated loyalty and adherence to the organization's rules in engaged employees. Perceived separation distress can increase interpersonal citizenship performance; however, it can decrease organizational compliance in engaged employees. Fear of losing the leader can potentially harm the organizational goals by favoring the personal relationships before organizational compliance.
Predictors of deliberate self-harm among adolescents: Answers from a cross-sectional study on India
Authors: Sinha Debashree , Srivastava Shobhit , Mishra Prem Shankar , Kumar Pradeep
Published: December 2021

Background

Although existing research supports the correlation of hereditary and psychological factors with an adolescent’s deliberate self-harm, there is a dearth of research that focus on their socio-economic characteristics. This paper intends to identity the potential risk factors that influence an adolescent’s deliberate self-harm.

Methods

Data for this study was obtained from Understanding the Lives of Adolescents and Young Adults (UDAYA) study conducted in 2015–16 with sample of 5,969 adolescent boys and 9,419 girls aged 10–19 years. The outcome variable was deliberate self-harm among adolescents. The explanatory variables added in the study were age, current schooling status, working status, media exposure, access to internet, parental abuse, involvement in fights, substance use, depressive symptoms, caste, religion, wealth index, residence and states. Bivariate analysis along with binary logistic regression analysis was done to fulfill the study objectives.

Results

About 4.5% and 3.2% of adolescent boys and girls, respectively had deliberate self-harm. The odds of deliberate self-harm were 50 per cent more likely among adolescent girls who had internet access [OR 1.50; CI 1.05–2.16]. The likelihood of deliberate self-harm was 49 per cent and 61 per cent significantly more likely among adolescent boys [OR 1.49; CI 1.11–2.0] and girls [OR 1.61; CI 1.27–2.04] who experienced parental physical abuse respectively. With reference to minimal/mild depressive symptoms, adolescents who had moderate [boys-OR 2.10; CI 1.29–3.4 and girls-OR 2.50; CI 1.774–3.59] or moderately high/severe [boys-OR 4.58; CI 2.88–7.29 and girls-OR 4.18; CI 3.1–5.63] depressive symptoms had significantly higher odds of deliberate self-harm.

Conclusions

Internet access, parental abuse, involvement in fights, and depressive symptoms emerged as significant predictors of deliberate self-harm among adolescent boys and girls. Results suggest that an early identification of the predictors and intervention might prevent deliberate self-harm among adolescents. Since parents play a major role in the lives and development of adolescents, it is highly recommended that they initiate open and supportive communication with their children.
Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease
Authors: Rovelet-Lecrux Anne , Feuillette Sebastien , Miguel Laetitia , Schramm Catherine , Pernet Ségolène , Quenez Olivier , Ségalas-Milazzo Isabelle , Guilhaudis Laure , Rousseau Stéphane , Riou Gaëtan , Frébourg Thierry , Campion Dominique , Nicolas Gaël , Lecourtois Magalie
Published: December 2021

The SorLA protein, encoded by the SORL1 gene, is a major player in Alzheimer’s disease (AD) pathophysiology. Functional and genetic studies demonstrated that SorLA deficiency results in increased production of Aβ peptides, and thus a higher risk of AD. A large number of SORL1 missense variants have been identified in AD patients, but their functional consequences remain largely undefined. Here, we identified a new pathophysiological mechanism, by which rare SORL1 missense variants identified in AD patients result in altered maturation and trafficking of the SorLA protein. An initial screening, based on the overexpression of 70 SorLA variants in HEK293 cells, revealed that 15 of them (S114R, R332W, G543E, S564G, S577P, R654W, R729W, D806N, Y934C, D1535N, D1545E, P1654L, Y1816C, W1862C, P1914S) induced a maturation and trafficking-deficient phenotype. Three of these variants (R332W, S577P, and R654W) and two maturation-competent variants (S124R and N371T) were further studied in details in CRISPR/Cas9-modified hiPSCs. When expressed at endogenous levels, the R332W, S577P, and R654W SorLA variants also showed a maturation defective profile. We further demonstrated that these variants were largely retained in the endoplasmic reticulum, resulting in a reduction in the delivery of SorLA mature protein to the plasma membrane and to the endosomal system. Importantly, expression of the R332W and R654W variants in hiPSCs was associated with a clear increase of Aβ secretion, demonstrating a loss-of-function effect of these SorLA variants regarding this ultimate readout, and a direct link with AD pathophysiology. Furthermore, structural analysis of the impact of missense variants on SorLA protein suggested that impaired cellular trafficking of SorLA protein could be due to subtle variations of the protein 3D structure resulting from changes in the interatomic interactions.
MiR-212-3p functions as a tumor suppressor gene in group 3 medulloblastoma via targeting nuclear factor I/B (NFIB)
Authors: Perumal Naveenkumar , Kanchan Ranjana K. , Doss David , Bastola Noah , Atri Pranita , Chirravuri-Venkata Ramakanth , Thapa Ishwor , Vengoji Raghupathy , Maurya Shailendra K. , Klinkebiel David , Talmon Geoffrey A. , Nasser Mohd W. , Batra Surinder K. , Mahapatra Sidharth
Published: December 2021

Haploinsufficiency of chromosome 17p and c-Myc amplification distinguish group 3 medulloblastomas which are associated with early metastasis, rapid recurrence, and swift mortality. Tumor suppressor genes on this locus have not been adequately characterized. We elucidated the role of miR-212-3p in the pathophysiology of group 3 tumors. First, we learned that miR-212-3p undergoes epigenetic silencing by histone modifications in group 3 tumors. Restoring its expression reduced cancer cell proliferation, migration, colony formation, and wound healing in vitro and attenuated tumor burden and improved survival in vivo. MiR-212-3p also triggered c-Myc destabilization and degradation, leading to elevated apoptosis. We then isolated an oncogenic target of miR-212-3p, i.e. NFIB, a nuclear transcription factor implicated in metastasis and recurrence in various cancers. Increased expression of NFIB was confirmed in group 3 tumors and associated with poor survival. NFIB silencing reduced cancer cell proliferation, migration, and invasion. Concurrently, reduced medullosphere formation and stem cell markers (Nanog, Oct4, Sox2, CD133) were noted. These results substantiate the tumor-suppressive role of miR-212-3p in group 3 MB and identify a novel oncogenic target implicated in metastasis and tumor recurrence.
Laccases as green and versatile biocatalysts: from lab to enzyme market—an overview
Authors: Brugnari Tatiane , Braga Dayane Moreira , dos Santos Camila Souza Almeida , Torres Bruno Henrique Czelusniak , Modkovski Tatiani Andressa , Haminiuk Charles Windson Isidoro , Maciel Giselle Maria
Published: December 2021

Laccases are multi-copper oxidase enzymes that catalyze the oxidation of different compounds (phenolics and non-phenolics). The scientific literature on laccases is quite extensive, including many basic and applied research about the structure, functions, mechanism of action and a variety of biotechnological applications of these versatile enzymes. Laccases can be used in various industries/sectors, from the environmental field to the cosmetics industry, including food processing and the textile industry (dyes biodegradation and synthesis). Known as eco-friendly or green enzymes, the application of laccases in biocatalytic processes represents a promising sustainable alternative to conventional methods. Due to the advantages granted by enzyme immobilization, publications on immobilized laccases increased substantially in recent years. Many patents related to the use of laccases are available, however, the real industrial or environmental use of laccases is still challenged by cost–benefit, especially concerning the feasibility of producing this enzyme on a large scale. Although this is a compelling point and the enzyme market is heated, articles on the production and application of laccases usually neglect the economic assessment of the processes. In this review, we present a description of laccases structure and mechanisms of action including the different sources (fungi, bacteria, and plants) for laccases production and tools for laccases evolution and prediction of potential substrates. In addition, we both compare approaches for scaling-up processes with an emphasis on cost reduction and productivity and critically review several immobilization methods for laccases. Following the critical view on production and immobilization, we provide a set of applications for free and immobilized laccases based on articles published within the last five years and patents which may guide future strategies for laccase use and commercialization.
Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells
Authors: Ning Rende , Chen Guang , Fang Run , Zhang Yanhui , Zhao Wenjuan , Qian Feng
Published: December 2021

Background

Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical treatment, remained unknown.

Methods

Colony formation assay, cell cycle analysis and apoptosis analysis were conducted respectively to observe the effect of diosmetin on cell proliferation and apoptosis in human osteosarcoma cells. Western blot and immunoprecipitation were used to detect the expression of apoptotic molecules and activation of STAT3/c-Myc pathway in Saos-2 and U2SO cells.

Results

Diosmetin significantly inhibited cell proliferation, induced cell cycle arrest at G2/M phase and promoted cell apoptosis in both Saos-2 and U2SO cells. Moreover, Diosmetin downregulated the expression of anti-apoptotic protein Bcl-xL while upregulated the levels of pro-apoptotic proteins including cleaved Caspase-3, cleaved-PARP and Bax. Furthermore, diosmetin dose-dependently inhibited STAT3 phosphorylation, reduced the expression of its downstream protein c-Myc and impeded the interaction between STAT3 molecules.

Conclusions

These results suggest that diosmetin exerts anti-osteosarcoma effects by suppressing cell proliferation and inducing apoptosis via inhibiting the activation of STAT3/c-Myc signaling pathway, which provide the possibility for diosmetin to be a chemotherapeutic candidate for osteosarcoma.
A robust model-free controller for a three-phase grid-connected photovoltaic system based on ultra-local model
Authors: Boubakir Ahsene , Touil Sid-Ahmed , Labiod Salim , Boudjerda Nasserdine
Published: December 2021

In this paper, a robust model-free controller for a grid-connected photovoltaic (PV) system is designed. The system consists of a PV generator connected to a three-phase grid by a DC/AC converter. The control objectives of the overall system are to extract maximum power from the PV source, to control reactive power exchange and to improve the quality of the current injected into the grid. The model-free control technique is based on the use of an ultra-local model instead of the dynamic model of the overall system. The local model is continuously updated based on a numerical differentiator using only the input–output behavior of the controlled system. The model-free controller consists of a classical feedback controller and a compensator for the effects of internal parameter changes and external disturbances. Simulation results illustrate the efficiency of the controller for grid-connected PV systems.
Maximum production point tracking method for a solar-boosted biogas energy generation system
Authors: Chen Jialin , Yang Ruijiang , Xu Da , Zhou Bin , Jin Yifang
Published: December 2021

Low biogas yield in cold climates has brought great challenges in terms of the flexibility and resilience of biogas energy systems. This paper proposes a maximum production point tracking method for a solar-boosted biogas generation system to enhance the biogas production rate in extreme climates. In the proposed method, a multi-dimensional R–C thermal circuit model is formulated to analyze the digesting thermodynamic effect of the anaerobic digester with solar energy injection, while a hydrodynamic model is formulated to express the fluid dynamic interaction between the hot-water circulation flow and solar energy injection. This comprehensive dynamic model can provide an essential basis for controlling the solar energy for digester heating to optimize anaerobic fermentation and biogas production efficiency in extreme climates. A model predictive control method is developed to accurately track the maximum biogas production rate in varying ambient climate conditions. Comparative results demonstrate that the proposed methodology can effectively control the fermentation temperature and biogas yield in extreme climates, and confirm its capability to enhance the flexibility and resilience of the solar-boosted biogas generation system.
Considerations for conducting and reporting digitally supported cognitive interviews with children and adults
Authors: Fry Abigail , Mitchell Sandra A. , Wiener Lori
Published: December 2021

Background

Cognitive interviewing is a well-established qualitative method used to develop and refine PRO measures. A range of digital technologies including phone, web conferencing, and electronic survey platforms can be leveraged to support the conduct of cognitive interviewing in both children and adults. These technologies offer a potential solution to enrolling underrepresented populations, including those with rare conditions, functional limitations and geographic or socioeconomic barriers. In the aftermath of the COVID-19 pandemic, the use of digital technologies for qualitative interviewing will remain essential. However, there is limited guidance about adapting cognitive interviewing procedures to allow for remote data capture, especially with children.

Methods

Synthesizing the literature and our research experiences during the COVID-19 pandemic, we examine considerations for implementing digitally supported cognitive interviews with children, adolescents, and adults. We offer recommendations to optimize data quality and empirical rigor and illustrate the application of these recommendations in an ongoing cognitive interviewing study to develop and refine a new pediatric PRO measure.

Results

Good research practices must address participant and researcher preparation for study-related procedures and should anticipate and pre-emptively manage technological barriers. Field notes should detail interview context, audio/video cues, and any impact of technological difficulties on data quality. The approaches we recommend have been tested in an ongoing cognitive interviewing study that is enrolling children/adolescents with cGVHD ages 5–17 and their caregivers [NCT 04044365]. The combined use of telephone and videoconferencing to conduct cognitive interviews remotely is feasible and acceptable and yields meaningful data to improve the content validity of our new PRO measure of cGVHD symptom bother.

Conclusion

Digitally supported cognitive interviewing procedures will be increasingly employed. Remote data collection can accelerate accrual, particularly in multi-site studies, and may allow for interviewer personnel and data management to be centralized within a coordinating center, thus conserving resources. Research is needed to further test and refine techniques for remote cognitive interviewing, particularly in traditionally underrepresented populations, including children and non-English speakers. Expansion of international standards to address digitally supported remote qualitative data capture appears warranted.
Combining patient reported outcomes and EHR data to understand population level treatment needs: correcting for selection bias in the migraine signature study
Authors: Stewart Walter F. , Yan Xiaowei , Pressman Alice , Jacobson Alice , Vaidya Shruti , Chia Victoria , Buse Dawn C. , Lipton Richard B.
Published: December 2021

Background

Electronic health records (EHR) data can be used to understand population level quality of care especially when supplemented with patient reported data. However, survey non-response can result in biased population estimates. As a case study, we demonstrate that EHR and survey data can be combined to estimate primary care population prescription treatment status for migraine stratified by migraine disability, without and with adjustment for survey non-response bias. We selected disability as it is associated with survey participation and patterns of prescribing for migraine.

Methods

A stratified random sample of Sutter Health adult primary care (PC) patients completed a digital survey about headache, migraine, and migraine related disability. The survey data from respondents with migraine were combined with their EHR data to estimate the proportion who had prescription orders for acute or preventive migraine treatments. Separate proportions were also estimated for those with mild disability (denoted “mild migraine”) versus moderate to severe disability (denoted mod-severe migraine) without and with correction, using the inverse propensity weighting method, for non-response bias. We hypothesized that correction for non-response bias would result in smaller differences in proportions who had a treatment order by migraine disability status.

Results

The response rate among 28,268 patients was 8.2%. Among survey respondents, 37.2% had an acute treatment order and 16.8% had a preventive treatment order. The response bias corrected proportions were 26.2% and 11.6%, respectively, and these estimates did not differ from the total source population estimates (i.e., 26.4% for acute treatments, 12.0% for preventive treatments), validating the correction method. Acute treatment orders proportions were 32.3% for mild migraine versus 37.3% for mod-severe migraine and preventive treatment order proportions were 12.0% for mild migraine and 17.7% for mod-severe migraine. The response bias corrected proportions for acute treatments were 24.8% for mild migraine and 26.6% for mod-severe migraine and the proportions for preventive treatment were 8.1% for mild migraine and 12.0% for mod-severe migraine.

Conclusions

In this study, we combined survey data with EHR data to better understand treatment needs among patients diagnosed with migraine. Migraine-related disability is directly related to preventive treatment orders but less so for acute treatments. Estimates of treatment status by self-reported disability status were substantially over-estimated among those with moderate to severe migraine-related disability without correction for non-response bias.
Space for the Sustainable Development Goals: mapping the contributions of space-based projects and technologies to the achievement of the 2030 Agenda for Sustainable Development
Authors: Baumgart André , Vlachopoulou Eirini Ioanna , Vera Jorge Del Rio , Di Pippo Simonetta
Published: December 2021

Progress towards the achievement of the 17 Sustainable Development Goals (SDGs) of the 2030 Agenda for Sustainable Development in many ways presupposes the utilisation of science, technology and innovation. Many sustainability-oriented projects across industries make use of space-based technologies and services to contribute to the Goals. Among others, satellite-based Earth observation, positioning, navigation and communication services are used in an array of sectors ranging from monitoring environmental conditions and changes to supporting search and rescue missions. In order to illustrate contributions to the SDGs, space agencies and other institutions have aligned their projects to the SDG framework. This study attempts a more holistic, aggregate mapping of such alignments to gauge which SDGs benefit the most and from space-based projects and technologies, as opposed to those benefiting the least. The results demonstrate that the number of contributing projects varies significantly across the Goal spectrum, as does the share of the various technologies involved, with particular focus on industrial development, hunger elimination, and improved healthcare. Nevertheless, the range of application of space-based technologies is wide and highlights the relevance of space to support the transition towards a sustainable future.
Serratus anterior plane block for cardiothoracic surgeries: a meta-analysis of randomized trials
Authors: Mostafa Tarek Abdel hay , El-Hamid Ahmed Mostafa Abd , Abdelgawad Basem Mofreh , Elbarbary Dina Hosny
Published: December 2021

Background

Comparison of serratus anterior plane block to different analgesic methods for anterolateral thoracic wall incisions. Meta-analysis was used to address this concern. Authors systemically searched the MEDLINE, EMBASE, PubMed, and Cochrane databases to identify all published randomized and prospective clinical trials, comparing the SAPB with other methods that used for analgesia in different thoracic surgical procedures and trauma.

Results

Ten studies were identified for inclusion in this study, involving a total of 735 patients. Meta-analysis showed that, compared with thoracic wall analgesia and PCA methods, the SAPB group resulted in a significant decrease in pain scores, significant decrease in consumption of analgesic drugs, and a significant decrease in the incidence of nausea and vomiting with no difference in the rate of hypotension.

Conclusions

The use of SAPB in cardiothoracic surgery and trauma is a safe and effective option for thoracic analgesia.
Strategies to implement SARS-CoV-2 point-of-care testing into primary care settings: a qualitative secondary analysis guided by the Behaviour Change Wheel
Authors: Kierkegaard Patrick , Hicks Timothy , Allen A. Joy , Yang Yaling , Hayward Gail , Glogowska Margaret , Nicholson Brian D. , Buckle Peter ,   on behalf of the CONDOR Steering Committee, Braybrook Julian , Dark Paul , Davis Kerrie , Cook Eloise , Gordon Adam , Halstead Anna , Lasserson Dan , Lewington Andrew , Perera-Salazar Rafael , Simpson John , Turner Philip , Prestwich Graham , Reynard Charles , Riley Beverley , Tate Valerie , Wilcox Mark
Published: December 2021

Background

The purpose of this study is to develop a theory-driven understanding of the barriers and facilitators underpinning physicians’ attitudes and capabilities to implementing SARS-CoV-2 point-of-care (POC) testing into primary care practices.

Methods

We used a secondary qualitative analysis approach to re-analyse data from a qualitative, interview study of 22 primary care physicians from 21 primary care practices across three regions in England. We followed the three-step method based on the Behaviour Change Wheel to identify the barriers to implementing SARS-CoV-2 POC testing and identified strategies to address these challenges.

Results

Several factors underpinned primary care physicians’ attitudes and capabilities to implement SARS-CoV-2 POC testing into practice. First, limited knowledge of the SARS-CoV-2 POC testing landscape and a demanding workload affected physicians’ willingness to use the tests. Second, there was scepticism about the insufficient evidence pertaining to the clinical efficacy and utility of POC tests, which affected physicians’ confidence in the accuracy of tests. Third, physicians would adopt POC tests if they were prescribed and recommended by authorities. Fourth, physicians required professional education and training to increase their confidence in using POC tests but also suggested that healthcare assistants should administer the tests. Fifth, physicians expressed concerns about their limited workload capacity and that extra resources are needed to accommodate any anticipated changes. Sixth, information sharing across practices shaped perceptions of POC tests and the quality of information influenced physician perceptions. Seventh, financial incentives could motivate physicians and were also needed to cover the associated costs of testing. Eighth, physicians were worried that society will view primary care as an alternative to community testing centres, which would change perceptions around their professional identity. Ninth, physicians’ perception of assurance/risk influenced their willingness to use POC testing if it could help identify infectious individuals, but they were also concerned about the risk of occupational exposure and potentially losing staff members who would need to self-isolate.

Conclusions

Improving primary care physicians’ knowledgebase of SARS-CoV-2 POC tests, introducing policies to embed testing into practice, and providing resources to meet the anticipated demands of testing are critical to implementing testing into practice.
Fly ash-based geopolymers: an emerging sustainable solution for heavy metal remediation from aqueous medium
Authors: Gupta Piyush , Nagpal Garima , Gupta Namrata
Published: December 2021

Background

The water supplies are hindered because aquatic resources have constrained with natural and man-made pollution activities in terms of releasing huge amounts of contaminants from different point and non-point sources across the globe. The industries like metal plating, batteries, paint, fertilizers, tanneries, textile industries, dyeing industries, mining operations, and paper industries discharge their effluents into the environment directly or indirectly, and hence, they are considered as the key sources of heavy metals contamination in water resources. Heavy metals are inorganic, non-biodegradable, persistent, and having a tendency to get accumulated in biotic and abiotic components of environment as compared to organic pollutants. Some heavy metal cations, for example, mercury, arsenic, cadmium, zinc, lead, nickel, copper, and chromium, are carcinogenic in nature and so, lethal. There are growing health concerns due to toxic impacts of heavy metals on every genre of ecosystem. To deal with the bottleneck situation, it is highly imperative to search a feasible solution for heavy metal remediation in water in context of preventing amalgamation of noxious contaminants in food web. Different methods are exercised for the remediation of such impurities from its solutions. One method, i.e. adsorption is found to be the simplest, economical, efficient, and eco-friendly in this context.

Main body

Geopolymers exhibit heterogeneous amorphous microstructure and wide surface area. The compatibility for depollution and the performance of these materials mainly depend upon their preparation methods, composition, and microstructure. Fly ash-based geopolymer may serve as a better alternate to various cost-effective adsorbents and it will be a proven environmentally viable, waste to money solution by consuming heaps of fly ash waste for the adsorbent modified by using fly ash. The possible utilization of wastes from several industries is a matter of concerned sustainability benefits. This study shows that fly ash-based geopolymers have the potential to cope up with the problems and risk factors associated with the fly ash waste management and it would be the utmost scientific panacea in the field of removing toxins from aqueous medium and maintain environmental health in the future.

Short conclusions

The literature available in different databases is very limited pertaining to heavy metal remediation using fly ash-based geopolymers. Keeping all the factors in mind, this article is an attempt to summarize relevant informations related to work done on fly ash-based geopolymers for treating aqueous solutions comprising heavy metals.
Kissel - liquid food
Authors: Litvyak V. V. , Roslyakov Yu.F. , Lukin N.D. , Kuzina L.B. , Kuzmina L.G.
Published: December 2021

В книге описана история появления киселя, дана общая характеристика киселя, приведена технология промышленного производства сухих сладких киселей и характеристика основных ингредиентов киселей (нативного крахмала, сахарозы и воды). Представлено большое количество кулинарных рецептов приготовления киселей овсяные, рисовые, ячменные, льняные, конопляные, зерновые, хлебные, квасные и из семян чиа, гороховые, чечевичные, соевые, а также простые сладких киселей из черной смородины, клюквы, малины, вишни, черешни, крыжовника, лимона, фиников, кизила, абрикосов, кураги, шиповника, бузины, облепихи, ежевики, калины, голубики, щавеля, тыквы, ревеня, черники, яблок, апельсин, груш, костяники, моркови, морошки, черемухи, меда, дыни, персиков, клубники, красной смородины, брусники, винограда, арбуза, грейпфрута, свеклы, земляники, рябины красной, ананаса, айвы, мандарин, слив, бананов, манго, авокадо, сухофруктов, боярышника, киви, черноплодной рябины, хурмы, шелковицы, маракуйи, граната, ирги, картофеля, топинамбура, сложных сладких киселей и киселей сладких из молочных продуктов. Для всех ингредиентов приводимых в рецептах киселей даны таблицы химического состава и калорийности. Представлены рецепты киселей на растительных настоях (на настоях лекарственных растениях и на чае), целебного киселя «Синий крахмал» или «Синий йод». Приведены правила получения нативного (картофельного и кукурузного) крахмала, а также правила заваривания крахмального клейстера Подробно описано возможное использование киселей в диетологии – в диетах для похудения. Данная книга может представлять интерес для пищевых технологов, работников сферы общественного питания, шеф-поварам, а также широкому кругу читателей интересующихся приготовлением вкусных и полезных блюд – киселей с минимальными затратами времени.
Porridge is our food
Authors: Litvyak V. V. , Roslyakov Yu.F. , Lukin N.D. , Kuzina L.B. , Kuzmina L.G.
Published: December 2021

В книге описана история появления каши, дана общая характеристика каши, кратко описана технология промышленного производства каши (крупяное и мучное производство), представлена характеристика основных ингредиентов каши (крупы, муки, нативного крахмала, сахарозы, поваренной соли, воды, молока, масел и жиров, мяса, а также других ингредиентов). Приведены кулинарные рецепты различных видов каш. Описаны кулинарные рецепты крахмальных каш, кулинарные рецепты солдатской или армейской каши, кулинарные рецепты сложных (многозерновых) каш. Кроме этого в книге описан способ персонификации питания с учетом генетически детерминированных факторов и приведены разнообразные кашевые диеты для похудения и оздоровления. Данная книга может представлять интерес для пищевых технологов, работников сферы общественного питания, шеф-поварам, диетологам, а также широкому кругу читателей интересующихся приготовлением вкусных и полезных блюд – различных каш с минимальными затратами времени.
MILK AND DAIRY PRODUCTS
Authors: Litvyak V. V. , LUKIN N.D. , ROSLYaKOV Yu.F. , KUZINA L.B.
Published: December 2021

В книге подробно описана история молока и молочных продуктов, дана общая характеристика молока, охарактеризованы разные виды молока, описаны разные виды молочных продуктов. Кроме этого, дана характеристика молочнокислых бактерий и заквасок, показана возможность употребления сыров в виде фондю и раклета, приведены особенности технологии разделения молока баромембранными процессами на компоненты. В книге приведены большое количество рецептов домашнего приготовления различных молочных продуктов. Приведены варианты использования молока и молочных продуктов в диетологии и косметологии. Данная книга может быть интересна для пищевых технологов, химиков, биологов, биохимиков, а также широкого круга читателей интересующихся молоком, молочными продуктами и технологией получения вкусных и питательных молочных продуктов и пищевых продуктов на основе молока.
A sequência (s,t)-Narayana
Authors: Vieira Renata Passos Machado , Alves Francisco Regis Vieira , Catarino Paula Maria Machado Cruz
Published: December 2021

Neste presente trabalho é definida a sequência (s,t)-Narayana, sendo portanto uma generalização dos coeficientes da fórmula de recorrência da sequência de Narayana. Assim, são estudadas as respectivas formas matriciais, função geradora, fórmula de Binet, equação característica e outros aspectos matemáticos referentes à essa nova sequência introduzida. Por fim, buscam-se novas propriedades desses números em outras áreas, investigando a sua aplicação.
HISTÓRIA, MATEMÁTICA E ENSINO: TRADIÇÕES, HARMONIZAÇÕES E INSUBORDINAÇÕES NECESSÁRIAS
Authors: De Assis Jean Felipe
Published: December 2021

João Bosco Pitombeira de Carvalho, em amplo diálogo com Gert Schubring, pondera a respeito da implementação da história da matemática na dinâmica cotidiana de ensino-aprendizagem. O autor salienta as seguintes dificuldades: estudos metodológicos sem resultados empíricos claros; má qualidade dos livros didáticos; baixo acesso às "fontes primárias"; distância entre "texto original" e "uso escolar"; carência de investimento na formação continuada de professores. Desse modo, contribuindo para essas reflexões, defende-se uma insubordinação epistemológica, a partir da qual práticas pedagógicas, dentre as quais algumas criativas, possibilitem experiências matemáticas em sala de aula a partir das premissas pluralistas herdadas das tradições históricas das ciências. Dentre as propostas recentes em educação matemática que podem contribuir para uma melhor integração da história da matemática no ensino, salientam-se: os estudos sobre cognição e linguagem; pensamento matemático avançado; modelagem matemática; investigação matemática em sala de aula.
A GENERALIZAÇÃO DOS OCTÔNIOS DE NARAYANA
Authors: Vieira Renata Passos Machado , Alves Francisco Regis Vieira , Catarino Paula Maria Machado Cruz
Published: December 2021

Nesta pesquisa são introduzidos os octônios de Narayana, realizando a sua generalização para os números inteiros não positivos. Dessa forma, são discutidas algumas propriedades matemáticas, com ênfase na forma matricial, função geradora, fórmula de Binet e dentr outros aspectos matemáticos. Por fim, buscam-se novas propriedades desses números em outras áreas, investigando a sua aplicação.
Geodésicas no Espaço Hiperbólico de dimensão 2
Authors: Santana Joyce Dominguez , Dutenhefner Francisco
Published: December 2021

O objetivo principal desse trabalho é definir uma linha geodésica real e uma geodésica complexa no espaço hiperbólico complexo de dimensão 2. Utilizando o modelo da bola explicitamos uma parametrização para os pontos da linha geodésica real que possui dois pontos finais dados na fronteira do espaço hiperbólico complexo. Já para as geodésicas complexas, que são subvariedades totalmente geodésicas do espaço hiperbólico complexo, além da definição, classificamos a posição relativa de duas delas como ultraparalelas, paralelas e concorrentes.
O ENSINO DE FUNÇÃO EXPONENCIAL NO ENSINO MÉDIO COM A UTILIZAÇÃO DO SOFTWARE GEOGEBRA: O ESBOÇO DE GRÁFICOS E A TECNOLOGIA DIGITAL COMO FERRAMENTA
Authors: Dos Santos Victor Balbino , Sousa Júlia Vieira , De Faria Elisabeth Cristina
Published: December 2021

Este estudo teve como objetivo investigar o uso do Geogebra como ferramenta no ensino de função exponencial. Investigou-se como os alunos esboçam e analisam gráficos de função exponencial após utilizarem o software. Como visto em Moraes e Peixoto em [2], a tecnologia digital é inserida na investigação como uma ferramenta em uma metodologia de ensino. Implementou-se uma sequência didática com três estudos dirigidos: no primeiro, deveriam esboçar o gráfico sem maiores instruções; no segundo, utilizando o Geogebra; no último, realizar o esboço manualmente. A investigação identificou que os alunos partiram de suas intuições, perpassaram o uso analítico do software e consolidaram a compreensão do comportamento ao final do terceiro estudo. Concluindo, entre a construção por intuição e a análise do gráfico construído no software os alunos apresentaram boa evolução dos aspectos visuais das funções exponenciais, mas os elementos que requereram uma análise mais qualitativa não apresentaram avanços significativos.
DESCARTES E A TANGENTE A UMA CURVA
Authors: Pitombeira João Bosco
Published: December 2021

A determinação das tangentes a curvas foi importante no século XVII e os matemáticos que precederam Newton e Leibniz, entre eles Roberval, Sluse, Fermat e Descartes desenvolveram vários métodos para isso.  Bem geral, o método de Descartes permite, em princípio, determinar as tangentes a qualquer curva algébrica , embora as dificuldades técnicas  possam   aumentar muito.  A regra de Hudde permite reduzir essas dificuldade
TECNOLOGIAS DE INFORMAÇÃO E COMUNICAÇÃO COMO ALTERNATIVAS PARA O ENSINO DE GEOGRAFIA: MEMÓRIAS E RELATOS DOCENTES
Authors: Pereira Thiago Barcelos , Borges Vilmar José
Published: December 2021

As tecnologias de informação e comunicação (TICs) fazem parte do cotidiano dos jovens estudantes da Educação Básica. Nesse sentido, o presente artigo objetiva socializar reflexões acerca de saberes e fazeres de professores de Geografia na busca pela incorporação das TICs  como alternativa para o ensino. Para tanto, apoiados na história oral, buscou-se narrativas de professores atuantes na Educação Básica nas redes pública municipal e estadual de ensino no município de Cariacica-ES, dando visibilidade aos saberes e fazeres de profissionais na incorporação das TICs como alternativa de ensino. A pesquisa revela que para além das dificuldades impostas pela realidade social e da escola pública, as TICs apresentam-se como potentes alternativas de ensino e de inclusão social.
MINHA SALA DE AULA É MEU LUGAR DE FALA? DESAFIOS EM TORNO DO CUMPRIMENTO DA LEI 10.639/03 EM TURMAS DE JOVENS E ADULTOS
Authors: Domingues Diego
Published: December 2021

Publicada há mais de quinze anos, a lei que estabelece a obrigatoriedade de trabalhar a temática “história e cultura afro-brasileira” na educação básica ainda encontra dificuldades para ser implementada em muitas rotinas escolares. Embora tenha uma importância inquestionável, nem sempre é fácil por em prática sua orientação, ainda mais quando muito antes de pensar ‘como fazer’ há a dúvida sobre ‘o que fazer’. Partindo de recentes experiências docentes, esse texto inicia apresentando uma breve contextualização histórica do surgimento da Lei 10639/03 e, em seguida, propõe indagações sobre qual o verdadeiro poder de agência do professor diante da organização dos conteúdos escolares, quais questionamentos atravessam a condução de um projeto pedagógico em torno do tema indicado pela Lei em discussão e como as expectativas docentes em todo esse processo precisam ser constantemente reelaboradas em diálogo com as demandas e repertórios dos alunos.
EXPERIÊNCIAS NO ESTÁGIO SUPERVISIONADO NA EJA EM TEMPOS DE PANDEMIA: PERCURSO E REFLEXÕES SOBRE A FORMAÇÃO DOCENTE
Authors: Santos Luiza Rodrigues dos , Ferreira Débora Europeu , Fernandes Ana Priscila , Lôbo Daniella Couto
Published: December 2021

O presente artigo, intitulado “Experiências no Estágio Supervisionado na EJA em tempos de pandemia: percurso e reflexões sobre a formação docente”, se circunscreve à apreensão de como se deu a experiência de Estágio Supervisionado III e IV. Considera os reflexos da pandemia da Covid-19, e tem por objetivo geral contribuir para a discussão sobre a experiência de Estágio Supervisionado na Educação de Jovens e Adultos (EJA). A metodologia é pautada pela pesquisa bibliográfica e os principais autores utilizados são Arroyo (2007), Freire (2017), Libâneo (2010; 2001) e Pimenta & Lima (2004). Diante disso, conclui que o cenário das aulas remotas tem intensificado as desigualdades sociais.
CURRÍCULOS E DESEJOS E CORPOS E... UMA MICROPOLÍTICA ATIVA COM OS COTIDIANOS DAS ESCOLAS PÚBLICAS EM TEMPOS FASCISTAS
Authors: Delmondes Marina De Oliveira
Published: December 2021

RESUMO: Essa escrita é um dos desdobramentos teóricos da pesquisa de doutorado que tem pensado (DELEUZE; GUATTARI, 2010) as relações entre corpos, currículos e cotidianos escolares a partir do campo epistemológico da filosofia da diferença e do aporte metodológico das pesquisas com os cotidianos. Em frente às maquinações capitalísticas que arregimentam os corpos a um dado desejo disciplinar, problematiza-se como os currículos praticados com os cotidianos das escolas podem fazer insurgir uma micropolítica ativa (ROLNIK, 2018) em tempos fascistas. Em diálogo com Deleuze e Guattari, Suely Rolnik, Carlos Eduardo Ferraço, Silvio Gallo, entre outros intercessores, pressupomos que essa insurgência dos corpos pode ser inventada a partir de uma arte da resistência.Palavras-chave: Currículos. Corpos. Desejos. Cotidiano escolar. Filosofia da Diferença.
NARRATIVAS DE VIDA: UM INSTRUMENTO SEMIÓTICO FAVORÁVEL AO TRABALHO DE ORIENTAÇÃO EDUCACIONAL NO ENSINO BÁSICO
Authors: França Mota Júnia Garcia , Freitas Ana Paula De
Published: December 2021

As projeções e a legitimidade do uso de narrativas de vida dos sujeitos na ciência e na educação vêm conquistando importante espaço no contexto escolar. Os estudos e as produções acerca dessa temática trazem, em sua essência, o destaque de seus valores como forma de expressão e de produção discursiva com foco nas singularidades, nos sentimentos, nos modos de vida e nos sentidos produzidos pelos sujeitos, a partir de sua experiência de vida em dado contexto histórico-cultural. Nesse viés, o objetivo desta produção é partilhar uma experiência com uso das narrativas de vida no contexto de uma escola de educação básica. Idealizada, desenvolvida e relatada pela orientadora educacional da instituição, a estratégia relatada pela especialista utilizou de produções escritas de alunos como instrumento semiótico com vistas a favorecer o aprimoramento das ações de orientação educacional em prol da educação inclusiva neste contexto.
UM PRÉ-VESTIBULAR SOCIAL E SUAS RELAÇÕES COM A EDUCAÇÃO FORMAL E NÃO FORMAL
Authors: Fournier Ana Cristina
Published: December 2021

O texto aborda um dos capítulos de uma pesquisa realizada com egressos trans de um pré-vestibular social que apresenta como foco a comunidade trans. O eixo que será compartilhado é uma reflexão teórica sobre como a educação formal e não formal se manifestam no cotidiano de um curso preparatório para o vestibular. Reflexões que contribuem para o entendimento sobre ambas e o foco na interpenetração das mesmas e não em suas categorizações. Tal combinação contribui para facilitar o percurso educacional dos estudantes de acordo com seu contexto, suas demandas e seus objetivos, visto que os educandos não são apenas alunos, mas sim participantes de uma vida social nos diferentes grupos e instituições. A amplitude da educação anuncia um ganho da dimensão de aprendizagem na vida de cada um.
A PEDAGOGIA VISUAL COMO FUNDAMENTAL NA EDUCAÇÃO DE SURDOS: SIGNIFICAÇÕES DO CORPO E AS EXPERIÊNCIAS VISUAIS DOS ALUNOS SURDOS
Authors: Lima da Silva Gomes Ellen Midiã , Bentes Thaisy , Da Silveira Calixto Hector Renan
Published: December 2021

Partindo do princípio de que as práticas pedagógicas embasadas na experiência visual contribuem para um melhor aprendizado dos alunos surdos, este estudo investigou o uso do corpo como estratégia de mediação pedagógica durante a implementação do protocolo do Livro Digital Acessível (LDA) em duas turmas de surdos matriculados no 3º ano do Ensino Fundamental I em uma escola pública de Duque de Caxias/RJ que adota como proposta pedagógica o Bilinguismo. Pretende-se neste texto analisar as representações visuais sobre o corpo enquanto suporte visual no processo de ensino e aprendizagem. A metodologia desta pesquisa embasou-se na perspectiva histórico-cultural (FREITAS, 2002; SOUZA, 2001), com viés da pesquisa participante (TRIPP, 2005). Participaram do estudo três professoras da educação básica e quatro alunos surdos. Conclui-se que explorar o corpo enquanto recurso visual nas significações do mundo contribuiu para que os conteúdos fossem compreendidos pelos alunos; o corpo enquanto marca cultural carrega as impressões sociais e que a mediação pedagógica foi fundamental para que os assuntos abordados em aula fossem compreendidos.
OS ESTRANHAMENTOS E OS DESAFIOS DE REALIZAR UMA PESQUISA COM CRIANÇAS – uma breve experiência
Authors: Amaral Débora Medeiros do
Published: December 2021

Compartilho neste texto um pouco da minha história e os caminhos percorridos na constituição de uma pesquisadora movida pelo desejo de investigar o que as crianças contavam sobre suas vivências em uma casa de abrigo, na tentativa de perceber como suas identidades iam sendo marcadas por essas vivências institucionalizadas. Ouvir as crianças, compreender suas manifestações e linguagens, não foram ações fáceis de realizar, pois em muitos momentos o adulto que habita em mim, não era capaz de compreender alguns gestos, manifestações e denúncias que eram feitas sem palavras. Hoje, compreendo que os caminhos que fui construindo para realizar uma pesquisa com crianças, orientaram meu fazer docente e meu fazer enquanto gestora escolar, os movimentos de escuta sensível, empatia e a busca inicial por compreender esse outro criança, adulto, estudante, professor, família foram me ensinando a ser educadora, professora, pedagoga, pesquisadora.
(DES)FORMAÇÃO DE PROFESSORES DE EDUCAÇÃO INFANTIL: OS APRENDERESFAZERES PRODUZIDOS NO COTIDIANO ESCOLAR
Authors: Silva Thiago Gonçalves , Lima de Salles Conceição Gislâne Nóbrega
Published: December 2021

O presente texto tem como objetivo compreender como as professoras de Educação Infantil experienciam, inventam e tecem seus aprenderesfazeres nos cotidianos escolares, em meio às suas relações com os quadros normativos de formação continuada. Neste artigo problematizamos a discussão sobre formação de professores à luz da perspectiva de formação inventiva, sendo este, um fragmento de uma pesquisa de mestrado em educação, realizada no interior de Pernambuco, com 25 professoras participantes.  Assim, a pesquisa foi construída a partir de um olhar e de um exercício investigativo cartográfico, que se constitui no acompanhamento dos aprenderesfazeres de docentes e de suas invenções, tecidas em movimentos de formação continuada em uma escola de Educação Infantil.  Trazemos nesse fragmento cenas, falas e elogios construídos pelas docentes durante o processo de pesquisa, potencializando as práticas docentes e suas infâncias através da formação inventiva.