bluuebunny/crossref_metadata_2025 huggingface dataset:
Damage to Residual Trees in Thinning of Broadleaf Stand by Mechanised Harvesting System
Authors: Ursić Branko , Vusić Dinko , Papa Ivica , Poršinsky Tomislav , Zečić Željko , Đuka Andreja
Published: January 2022

This research was conducted to determine the cause, intensity and location of damage (stem, butt end, root collar, root) and the extent of damage to standing trees during felling and processing by an harvester and timber extraction by a forwarder (cut-to-length system). The research was conducted in the central part of the Republic of Croatia in the Management Unit (MU) “Bjelovarska Bilogora” during the thinning of Subcompartment 14b, area of 18.28 ha, in the stand of hornbeam (Carpino betuli—Quercetum roboris fagetosum Rauš 1975), age 70, and of Subcompartment 14c, area of 9.07 ha, in a stand of common beech (Carici pilosae—Fagetum Oberdorfer 1957) aged 79 years. The thinning intensity was 12.13% in Subcompartment 14b and 13.72% in Subcompartment 14c. Field measurements were carried out on sample plots—the first time in 2017 to determine the intensity and characteristics of the damage to standing trees with regard to the cause of the damage (harvester or forwarder), and the second time in 2018 to determine the overall intensity and features of the damage to standing trees after finishing harvesting operations. For all trees remaining in the stand after the harvesting operations, the following were determined: tree species, diameter at breast height (DBH), the position of the tree in the stand depending on the forest traffic infrastructure, and—if damaged—cause of damage, type of damage, the position of damage on the tree, and dimensions of damage. The intensity of the damage was expressed by the ratio of damaged and undamaged trees, with a detailed analysis of bark damage (squeezed-bark damage and peeled-bark injuries). The results of the research indicate the highest prevalence of peeled-bark injuries. In relation to the total number of standing trees, trees with peeled-bark injuries were more represented in Subcompartment 14c (39%) than in Subcompartment 14b (33%). In Subcompartment 14b, the harvester and the forwarder damaged an equal number of trees, while in Subcompartment 14c, the harvester damaged 59% of the damaged trees. In both subcompartments, an average of 83% of (peeled bark) injuries were up to 1.3 m above the ground. In both subcompartments, the most common (67%) were injuries up to 100 cm2 in size, for which many authors claim the tree can heal by itself. Given the increasing use of harvester-forwarder systems in deciduous stands and research results that indicate possible damage to standing trees, it is necessary to pay attention to all phases of planning and execution of timber harvesting operations, thus minimising negative effects.
Spatial–Temporal Changes and Driving Force Analysis of Ecosystems in the Loess Plateau Ecological Screen
Authors: Su Kai , Liu Hongjun , Wang Huiyuan
Published: January 2022

The ecological degradation caused by unreasonable development and prolonged utilization threatens economic development. In response to the development crisis triggered by ecological degradation, the Chinese government launched the National Barrier Zone (NBZ) Construction Program in 2006. However, few in-depth studies on the Loess Plateau Ecological Screen (LPES) have been conducted since the implementation of that program. To address this omission, based on the remote sensing image as the primary data, combined with meteorological, soil, hydrological, social, and economic data, and using GIS spatial analysis technology, this paper analyzes the change characteristics of the ecosystem pattern, quality, and dominant services of the ecosystem in the LPES from 2005 to 2015. The results show that from 2005 to 2015, the ecosystem structure in the study area was relatively stable, and the area of each ecosystem fluctuated slightly. However, the evaluation results based on FVC, LAI, and NPP showed that the quality of the ecosystem improved. The vegetation coverage (FVC) increased significantly at a rate of 0.91% per year, and the net primary productivity (NPP) had increased significantly at a rate of 6.94 gC/(m2∙a) per year. The leaf area index (LAI) in more than 66% of the regions improved, but there were still about 8% of the local regions that were degraded. During these 10 years, the soil erosion situation in LPES improved overall, and the amount of soil conservation (ASC) of the ecosystem in the LPES increased by about 0.18 billion tons. Grassland and forest played important roles in soil conservation in this area. Pearson correlation analysis and redundancy analysis showed that the soil conservation services (SCS) in the LPES were mainly affected by climate change, economic development, and urban construction. The precipitation (P), total solar radiation (SOL), and temperature (T) can explain 52%, 30.1%, and 17% of the change trends of SCS, respectively. Construction land and primary industry were negatively correlated with SCS, accounting for 22% and 8% of the change trends, respectively. Overall, from 2005 to 2015, the ecological environment of LPES showed a gradual improvement trend, but the phenomenon of destroying grass and forests and reclaiming wasteland still existed.
Morphological and Chemical Variation of Wild Sweet Chestnut (Castanea sativa Mill.) Populations
Authors: Poljak Igor , Vahčić Nada , Liber Zlatko , Šatović Zlatko , Idžojtić Marilena
Published: January 2022

Sweet chestnut (Castanea sativa Mill., Fagaceae) is one of the oldest cultivated tree species in the Mediterranean, providing multiple benefits, and, since it has edible seeds, it represents an interesting model species for the research of morphological and chemical variability. In this study, morphometric methods and chemical analyses were used to quantify the extent of differences in phenotypic and nutritional traits between eight natural populations of sweet chestnut from different environmental conditions, where different management types are applied, high-forest and coppice. The samples were collected from the Prealps in Italy to the western part of Bosnia and Herzegovina. In total, 31 nut and kernel morphometric and nutritional traits were studied on 160 trees, and various multivariate statistical analyses were used to study intra- and interpopulation variations. Both analyses, morphometric and chemical, revealed a similar pattern of diversity, with morphological and chemical variability not associated with geographic or environmental variables. In addition, we found significant correlations between morphometric and chemical data. High phenotypic variability was determined both among and within the studied populations, and all populations had a similar level of diversity. The results of the analysis of morphological and chemical diversity can have many practical applications for the management, production, and conservation of the sweet chestnut genetic resources for nut production.
Distribution, Dominance Structure, Species Richness, and Diversity of Bats in Disturbed and Undisturbed Temperate Mountain Forests
Authors: Piksa Krzysztof , Brzuskowski Tomasz , Zwijacz-Kozica Tomasz
Published: January 2022

The increase in mean annual temperature and reduction in summer rainfall from climate change seem to increase the frequency of natural and human-made disturbances to forest vegetation. This type of rapid vegetation change also significantly affects bat diversity. The aim of our study was to document differences in the ecological parameters of bat assemblages in different types of temperate mountain forests, particularly between disturbed and undisturbed coniferous and deciduous forests. Additionally, these issues were considered along an elevation gradient. We mist netted bats on 73 sites, between 931 and 1453 m elevation, in the forests of the Tatra Mountains in southern Poland. During 2016–2020, 745 bats, representing 15 species, were caught. The most abundant were Myotis mystacinus (Kuhl, 1817) (53.0%) and M. brandtii (Eversmann, 1845) (21.5%). We observed differences in species diversity, elevational distribution, and dominance between different types of forests and forest zones. Species richness peaked at around 1000–1100 m elevation. The highest species richness and other indices were observed in undisturbed beech stands, although they constituted only about 2.7% of the forest area. The lowest species diversity was observed in disturbed coniferous forests, in both the lower and upper forest zone. The species richness and dominance structure of bat assemblages were also found to depend on the location above sea level. In some bat species, the sex ratio was higher at higher elevations, and differences in the sex ratio in a few bat species, between different types of forests, were observed. Our findings suggest that disturbed, beetle-killed spruce forests are an unsuitable environment for some bat species.
Air Entrainment in Drop Shafts: A Novel Approach Based on Machine Learning Algorithms and Hybrid Models
Authors: Granata Francesco , Di Nunno Fabio
Published: January 2022

Air entrainment phenomena have a strong influence on the hydraulic operation of a plunging drop shaft. An insufficient air intake from the outside can lead to poor operating conditions, with the onset of negative pressures inside the drop shaft, and the choking or backwater effects of the downstream and upstream flows, respectively. Air entrainment phenomena are very complex; moreover, it is impossible to define simple functional relationships between the airflow and the hydrodynamic and geometric variables on which it depends. However, this problem can be correctly addressed using prediction models based on machine learning (ML) algorithms, which can provide reliable tools to tackle highly nonlinear problems concerning experimental hydrodynamics. Furthermore, hybrid models can be developed by combining different machine learning algorithms. Hybridization may lead to an improvement in prediction accuracy. Two different models were built to predict the overall entrained airflow using data obtained during an extensive experimental campaign. The models were based on different combinations of predictors. For each model, four different hybrid variants were developed, starting from the three individual algorithms: KStar, random forest, and support vector regression. The best predictions were obtained with the model based on the largest number of predictors. Moreover, across all variants, the one based on all three algorithms proved to be the most accurate.
Application of Direct Numerical Simulation to Determine the Correlation Describing Friction Losses during the Transverse Flow of Fluid in Hexagonal Array Pin Bundles
Authors: Shvetsov Yury E. , Khomyakov Yury S. , Bayaskhalanov Mikhail V. , Dichina Regina P.
Published: January 2022

This paper presents the results of a numerical simulation to determine the hydraulic resistance for a transverse flow through the bundle of hexagonal rods. The calculations were carried out using the precision CFD code CONV-3D, intended for direct numerical simulation of the flow of an incompressible fluid (DNS-approximation) in the parts of fast reactors cooled by liquid metal. The obtained dependencies of the pressure drop and the coefficient of anisotropy of friction on the Reynolds number can be used in the thermal-hydraulic codes that require modeling of the flow in similar structures and, in particular, in the inter-wrapper space of the reactor core.
The New Face of Berries: A Review of Their Antiviral Proprieties
Authors: Bernier Charlie , Goetz Coralie , Jubinville Eric , Jean Julie
Published: January 2022

Due to rising consumer preference for natural remedies, the search for natural antiviral agents has accelerated considerably in recent years. Among the natural sources of compounds with potential antiviral proprieties, berries are interesting candidates, due to their association with health-promoting properties, including antioxidant, antimutagenic, anticancer, antimicrobial, anti-inflammatory, and neuroprotective properties. The past two decades have witnessed a flurry of new findings. Studies suggest promising antiviral proprieties against enveloped and non-enveloped viruses, particularly of cranberries, blueberries, blackcurrants, black raspberries, and pomegranates. The aim of this review is to assemble these findings, to list the implied mechanisms of action, and thereby point out promising subjects for research in this field, in the hope that compounds obtainable from natural sources such as berries may be used someday to treat, or even prevent, viral infections.
Meat Analogues in the Perspective of Recent Scientific Research: A Review
Authors: Kołodziejczak Klaudia , Onopiuk Anna , Szpicer Arkadiusz , Poltorak Andrzej
Published: January 2022

There are many reasons why consumers and food producers are looking for alternatives to meat and meat products, which includes the following: health, environmental or ethical aspects. This study reviews recent scientific reports on meat analogues. The scope of the review includes the following: formulation and nutritional value; health safety and legal regulations; manufacturing and processing technologies including the latest developments in this area; product availability on the food market; and consumer attitudes towards meat analogues. The analysis of the literature data identified technological challenges, particularly in improving consumer acceptability of meat analogues. Among the risks and limitations associated with the production of meat analogues, the following were identified: contamination from raw materials and the risk of harmful by-products due to intensive processing; legal issues of product nomenclature; and consumer attitudes towards substituting meat with plant-based alternatives. The need for further research in this area, particularly on the nutritional value and food safety of meat analogues, was demonstrated.
Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens
Authors: Aguirre Garcia Mayra , Hillion Killian , Cappelier Jean-Michel , Neunlist Michel , Mahe Maxime M. , Haddad Nabila
Published: January 2022

Foodborne diseases cause high morbidity and mortality worldwide. Understanding the relationships between bacteria and epithelial cells throughout the infection process is essential to setting up preventive and therapeutic solutions. The extensive study of their pathophysiology has mostly been performed on transformed cell cultures that do not fully mirror the complex cell populations, the in vivo architectures, and the genetic profiles of native tissues. Following advances in primary cell culture techniques, organoids have been developed. Such technological breakthroughs have opened a new path in the study of microbial infectious diseases, and thus opened onto new strategies to control foodborne hazards. This review sheds new light on cellular messages from the host–foodborne pathogen crosstalk during in vitro organoid infection by the foodborne pathogenic bacteria with the highest health burden. Finally, future perspectives and current challenges are discussed to provide a better understanding of the potential applications of organoids in the investigation of foodborne infectious diseases.
A Systematic Review on the Usability of Web-Based Applications in Advocating Consumers on Food Safety
Authors: Seow Wen-Li , Md Ariffin Umi Kalsom , Lim Sook Yee , Mohamed Nurul Azmawati , Lee Kai Wei , Devaraj Navin Kumar , Amin-Nordin Syafinaz
Published: January 2022

Food safety is an important indicator of public health, as foodborne illnesses continue to cause productivity and economic loss. In recent years, web-based applications have been extensively used by the online users’ population. Almost one third (28.3%) of online users found web-based application to be a notable source of food safety information. The objective of the current review is to determine the effectiveness of a web-based application systems as a health promotion tool for consumers to increase their knowledge and awareness of food safety. A systematic literature review was conducted by analyzing 11 selected web-based food safety education-related articles. The studies were categorized into several themes: (1) web-based applications used in accessing food safety information; (2) food safety evaluation and perception among consumers; (3) beliefs and level of knowledge, attitude and practices (KAP) of consumers; and (4) impact and contribution of social media use. A diverse number of online applications have been utilized to promote food safety education among consumers, yet these web-based applications need to be improved with regards to social connection and integration among consumers. KAP surveys were conducted on the majority of the respondents with a particular focus on their knowledge level. Findings show that web-based applications may act as an alternative to the traditional media in enhancing food safety education among consumers, especially youths who are tech-savvy.
Investigation of Finite-Difference Schemes for the Numerical Solution of a Fractional Nonlinear Equation
Authors: Tverdyi Dmitriy , Parovik Roman
Published: January 2022

The article discusses different schemes for the numerical solution of the fractional Riccati equation with variable coefficients and variable memory, where the fractional derivative is understood in the sense of Gerasimov-Caputo. For a nonlinear fractional equation, in the general case, theorems of approximation, stability, and convergence of a nonlocal implicit finite difference scheme (IFDS) are proved. For IFDS, it is shown that the scheme converges with the order corresponding to the estimate for approximating the Gerasimov-Caputo fractional operator. The IFDS scheme is solved by the modified Newton’s method (MNM), for which it is shown that the method is locally stable and converges with the first order of accuracy. In the case of the fractional Riccati equation, approximation, stability, and convergence theorems are proved for a nonlocal explicit finite difference scheme (EFDS). It is shown that EFDS conditionally converges with the first order of accuracy. On specific test examples, the computational accuracy of numerical methods was estimated according to Runge’s rule and compared with the exact solution. It is shown that the order of computational accuracy of numerical methods tends to the theoretical order of accuracy with increasing nodes of the computational grid.
Elegies and Laments in the Nova Scotia Gaelic Song Tradition: Conservatism and Innovation
Authors: Dunbar Robert Douglas
Published: January 2022

Gaelic-speaking emigrants brought with them a massive body of oral tradition, including a rich and varied corpus of song–poetry, and many of the emigrants were themselves highly skilled song-makers. Elegies were a particularly prominent genre that formed a crucially important aspect of the sizeable amount of panegyric verse for members of the Gaelic aristocracy, which is a tradition dating back to the Middle Ages. This contribution will demonstrate that elegies retained a prominent place in the Gaelic tradition in the new world Gaelic communities established in many parts of Canada and in particular in eastern Nova Scotia. In many respects, the tradition is a conservative one: there are strong elements of continuity. One important difference is the subjects for whom elegies were composed: in the new world context, praise for clan chiefs and other members of the traditional Gaelic aristocracy were no longer of relevance, although a small number were composed primarily out of a sense of personal obligation for patronage shown in the Old Country. Instead—and as was increasingly happening in the nineteenth century in Scotland, as well—the deaths of new community leaders, including clergy, and other prominent Gaels were recorded in verse. The large number of songs composed to mark the deaths of community members is also important—particularly young people lost at sea and in other tragic circumstances, occasionally in military service, and so forth. In these song–poems, we see local poets playing a role assumed by song-makers throughout Gaelic-speaking Scotland and Ireland: that of spokespeople for the community as a whole.
How Key Psychological Theories Can Enrich Our Understanding of Our Ancestors and Help Improve Mental Health for Present and Future Generations: A Family Historian’s Perspective
Authors: Parker-Drabble Helen
Published: January 2022

Family historians could increase their understanding of their ancestors and themselves and improve the mental health of living and future generations if they consider the psychological history of their forebears. Genealogists could then begin to recognize their family’s unique psychological inheritance that can appear as a result of trauma, depression, or addiction. The author explores three generations of a Parker family branch from Huntingdon/Norfolk, England, to show family historians how such considerations can shed light on their family’s psychological legacy. The author does this by introducing us to her great-grandmother Ann grandfather Walter, and mother Doreen through the lens of attachment theory, and their adverse childhood experiences (ACEs) such as poverty, bereavement, and addiction. Attachment matters because it affects not only how safe we feel, our ability to regulate our emotions and stress, our adaptability, resilience, and lifelong mental and physical health, but attachment style can also be passed on. In addition, this paper utilizes attachment theory to speculate on the likely attachment styles for the three generations of the Parker family and looks at the possible parenting behavior in the first two, the effect of alcoholism and the intergenerational impact of trauma and depression.
Genetic Diversity and Differentiation of Eleven Medicago Species from Campania Region Revealed by Nuclear and Chloroplast Microsatellites Markers
Authors: Djedid Imene Khadidja , Terzaghi Mattia , Brundu Giuseppe , Cicatelli Angela , Laouar Meriem , Guarino Francesco , Castiglione Stefano
Published: January 2022

The species belonging to the genus Medicago are considered a very important genetic resource at global level both for planet’s food security and for sustainable rangelands management. The checklist of the Italian flora (2021) includes a total number of 40 Medicago species for Italy, and 27 for Campania region, with a number of doubtful records or related to species no more found in the wild. In this study, 10 Medicago species native to Campania region, and one archaeophyte (M. sativa), identified by means of morphological diagnostic characters, were analyzed in a blind test to assay the efficacy of nine microsatellite markers (five cp-SSRs and four n-SSRs). A total number of 33 individuals from 6 locations were sampled and genotyped. All markers were polymorphic, 40 alleles were obtained with n-SSRs ranging from 8–12 alleles per locus with an average of 10 alleles per marker, PIC values ranged from 0.672 to 0.847, and the most polymorphic SSR was MTIC 564. The cp-SSRs markers were highly polymorphic too; PIC values ranged from 0.644 to 0.891 with an average of 0.776, the most polymorphic cp-SSR was CCMP10. 56 alleles were obtained with cp-SSRs ranging from 7 to 17 alleles per locus with an average of 11. AMOVA analysis with n-SSR markers highlighted a great level of genetic differentiation among the 11 species, with a statistically significant fixation index (FST). UPGMA clustering and Bayesian-based population structure analysis assigned these 11 species to two main clusters, but the distribution of species within clusters was not the same for the two analyses. In conclusion, our results demonstrated that the combination of the used SSRs well distinguished the 11 Medicago species. Moreover, our results demonstrated that the use of a limited number of SSRs might be considered for further genetic studies on other Medicago species.
Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog
Authors: Kang Mingue , Ahn Byeongyong , Youk Seungyeon , Lee Yun-Mi , Kim Jong-Joo , Ha Ji-Hong , Park Chankyu
Published: January 2022

Genetic analysis of the hair-length of Sapsaree dogs, a Korean native dog breed, showed a dominant mode of inheritance for long hair. Genome-Wide Association Study (GWAS) analysis and subsequent Mendelian segregation analysis revealed an association between OXR1, RSPO2, and PKHD1L1 on chromosome 13 (CFA13). We identified the previously reported 167 bp insertion in RSPO2 3’ untranslated region as a causative mutation for hair length variations. The analysis of 118 dog breeds and wolves revealed the selection signature on CFA13 in long-haired breeds. Haplotype analysis showed the association of only a few specific haplotypes to the breeds carrying the 167 bp insertion. The genetic diversity in the neighboring region linked to the insertion was higher in Sapsarees than in other Asian and European dog breeds carrying the same variation, suggesting an older history of its insertion in the Sapsaree genome than in that of the other breeds analyzed in this study. Our results show that the RSPO2 3’ UTR insertion is responsible for not only the furnishing phenotype but also determining the hair length of the entire body depending on the genetic background, suggesting an epistatic interaction between FGF5 and RSPO2 influencing the hair-length phenotype in dogs.
Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study
Authors: Ardissino Maddalena , Reddy Rohin K. , Slob Eric A. W. , Patel Kiran H. K. , Ryan David K. , Gill Dipender , Ng Fu Siong
Published: January 2022

It remains unclear whether the association between obstructive sleep apnoea (OSA), a form of sleep-disordered breathing (SDB), and atrial fibrillation (AF) is causal or mediated by shared co-morbidities such as obesity. Existing observational studies are conflicting and limited by confounding and reverse causality. We performed Mendelian randomisation (MR) to investigate the causal relationships between SDB, body mass index (BMI) and AF. Single-nucleotide polymorphisms associated with SDB (n = 29) and BMI (n = 453) were selected as instrumental variables to investigate the effects of SDB and BMI on AF, using genetic association data on 55,114 AF cases and 482,295 controls. Primary analysis was conducted using inverse-variance weighted MR. Higher genetically predicted SDB and BMI were associated with increased risk of AF (OR per log OR increase in snoring liability 2.09 (95% CI 1.10–3.98), p = 0.03; OR per 1-SD increase in BMI 1.33 (95% CI 1.24–1.42), p < 0.001). The association between SDB and AF was not observed in sensitivity analyses, whilst associations between BMI and AF remained consistent. Similarly, in multivariable MR, SDB was not associated with AF after adjusting for BMI (OR 0.68 (95% CI 0.42–1.10), p = 0.12). Higher BMI remained associated with increased risk of AF after adjusting for OSA (OR 1.40 (95% CI 1.30–1.51), p < 0.001). Elevated BMI appears causal for AF, independent of SDB. Our data suggest that the association between SDB, in general, and AF is attributable to mediation or confounding from obesity, though we cannot exclude that more severe SDB phenotypes (i.e., OSA) are causal for AF.
Evaluating Scaling Frameworks for Multiscale Geomorphometric Analysis
Authors: Newman Daniel R. , Cockburn Jaclyn M. H. , Drǎguţ Lucian , Lindsay John B.
Published: January 2022

Multiscale methods have become progressively valuable in geomorphometric analysis as data have become increasingly detailed. This paper evaluates the theoretical and empirical properties of several common scaling approaches in geomorphometry. Direct interpolation (DI), cubic convolution resampling (RES), mean aggregation (MA), local quadratic regression (LQR), and an efficiency optimized Gaussian scale-space implementation (fGSS) method were tested. The results showed that when manipulating resolution, the choice of interpolator had a negligible impact relative to the effects of manipulating scale. The LQR method was not ideal for rigorous multiscale analyses due to the inherently non-linear processing time of the algorithm and an increasingly poor fit with the surface. The fGSS method combined several desirable properties and was identified as an optimal scaling method for geomorphometric analysis. The results support the efficacy of Gaussian scale-space as a general scaling framework for geomorphometric analyses.
Perioperative Care in Colorectal Cancer Surgery before a Structured Implementation Program of the ERAS Protocol in a Regional Network. The Piemonte EASY-NET Project
Authors: Pellegrino Luca , Pagano Eva , Allaix Marco Ettore , Morino Mario , Muratore Andrea , Massucco Paolo , Rinaldi Federica , Ciccone Giovannino , Borghi Felice ,   the ERAS Colon-Rectum Piemonte Group
Published: January 2022

Background: In 2019, the Enhanced Recovery After Surgery (ERAS) protocol for colorectal cancer surgery was adopted by a minority of hospitals in Piemonte (4.3 million inhabitants, north-west Italy). The present analysis aims to compare the level of application of the ERAS protocol between hospitals already adopting it (ERAS, N = 3) with the rest of the regional hospitals (non-ERAS, N = 28) and to identify possible obstacles to its application. Methods: All patients surgically treated for a newly diagnosed colorectal cancer during September–November 2019, representing the baseline period of a randomized controlled trial with a cluster stepped-wedge design, were included. Indicators of compliance to the ERAS items were calculated overall and for groups of items (preoperative, intraoperative and postoperative) and analyzed with a multilevel linear model adjusting for patients’ characteristics, considering centers as random effects. Results: Overall, the average level of compliance to the ERAS protocol was 56% among non-ERAS centers (N = 364 patients) and 80% among ERAS ones (N = 79), with a difference of 24% (95% CI: −41.4; −7.3, p = 0.0053). For both groups of centers, the lowest level of compliance was recorded for postoperative items (42% and 66%). Sex, age, presence of comorbidities and American Society of Anesthesiologists (ASA) score were not associated with a different probability of compliance to the ERAS protocol. Conclusions: Several items of the ERAS protocol were poorly adopted in colorectal surgery units in the Piemonte region in the baseline period of the ERAS Colon-Rectum Piemonte study and in the ERAS group. No relevant obstacles to the ERAS protocol implementation were identified at patient level.
Immunotherapy-Related Publications in Colorectal Cancer: A Bibliometric Analysis
Authors: Sur Daniel , Lungulescu Cristina , Puscariu Irina-Ioana , Volovat Simona Ruxandra , Preda Madalina , Mateianu Elena Adriana , Lungulescu Cristian Virgil
Published: January 2022

Patients with microsatellite-instability-high (MSI-H) or mismatched repair-deficient colorectal cancer (CRC) appear to be responsive to checkpoint inhibitors. This study aimed to assess research trends in CRC immunotherapy. Publication patterns of articles covering immunotherapies in CRC in the Web of Science Core Collection database were retrospectively examined using VOS viewer software (version 1.6.16) prior to 25 May 2021. Ultimately, 3977 records were identified that were published between 1975 and 2021, which received a total of 128,681 citations (an average of 32.36 citations per item), with a noticeable rise in 2014. The majority of articles were published in the US (35.8%), China (17.7%), and Germany (9.4%). Publications mainly originated from the Institut National de la Santé Et De La Recherche Medicale Inserm, followed by the University of Texas System and Harvard University; however, Johns Hopkins University received the most citations (18,666 for 69 publications). The Journal of Clinical Oncology issued the most publications (n = 146), while the most referenced item (7724 citations) was published in the New England Journal of Medicine in 2012. The most common keywords were associated with tumors (expression and microsatellite instability) or immune system components (t-cells/dendritic cells). The findings demonstrate the scientific community’s interest in the MSI-H subtype of colorectal tumors and how immunotherapy may be employed more successfully to treat metastatic CRC.
Phenotypic Disease Network Analysis to Identify Comorbidity Patterns in Hospitalized Patients with Ischemic Heart Disease Using Large-Scale Administrative Data
Authors: Zhou Dejia , Wang Liya , Ding Shuhan , Shen Minghui , Qiu Hang
Published: January 2022

Ischemic heart disease (IHD) exhibits elevated comorbidity. However, few studies have systematically analyzed the comorbid status of IHD patients with respect to the entire spectrum of chronic diseases. This study applied network analysis to provide a complete picture of physical and mental comorbidities in hospitalized patients with IHD using large-scale administrative data. Hospital discharge records from a provincial healthcare database of IHD inpatients (n = 1,035,338) and one-to-one matched controls were included in this retrospective analysis. We constructed the phenotypic disease networks in IHD and control patients and further assessed differences in comorbidity patterns. The community detection method was applied to cluster diagnoses within the comorbidity network. Age- and sex-specific patterns of IHD comorbidities were also analyzed. IHD inpatients showed 50% larger comorbid burden when compared to controls. The IHD comorbidity network consisted of 1941 significant associations between 71 chronic conditions. Notably, the more densely connected comorbidities in IHD patients were not within the highly prevalent ones but the rarely prevalent ones. Two highly interlinked communities were detected in the IHD comorbidity network, where one included hypertension with heart and multi-organ failures, and another included cerebrovascular diseases, cerebrovascular risk factors and anxiety. Males exhibited higher comorbid burden than females, and thus more complex comorbidity relationships were found in males. Sex-specific disease pairs were detected, e.g., 106 and 30 disease pairs separately dominated in males and females. Aging accounts for the majority of comorbid burden, and the complexity of the comorbidity network increased with age. The network-based approach improves our understanding of IHD-related comorbidities and enhances the integrated management of patients with IHD.
Empirical Study on Classifiers for Earlier Prediction of COVID-19 Infection Cure and Death Rate in the Indian States
Authors: Guleria Pratiyush , Ahmed Shakeel , Alhumam Abdulaziz , Srinivasu Parvathaneni Naga
Published: January 2022

Machine Learning methods can play a key role in predicting the spread of respiratory infection with the help of predictive analytics. Machine Learning techniques help mine data to better estimate and predict the COVID-19 infection status. A Fine-tuned Ensemble Classification approach for predicting the death and cure rates of patients from infection using Machine Learning techniques has been proposed for different states of India. The proposed classification model is applied to the recent COVID-19 dataset for India, and a performance evaluation of various state-of-the-art classifiers to the proposed model is performed. The classifiers forecasted the patients’ infection status in different regions to better plan resources and response care systems. The appropriate classification of the output class based on the extracted input features is essential to achieve accurate results of classifiers. The experimental outcome exhibits that the proposed Hybrid Model reached a maximum F1-score of 94% compared to Ensembles and other classifiers like Support Vector Machine, Decision Trees, and Gaussian Naïve Bayes on a dataset of 5004 instances through 10-fold cross-validation for predicting the right class. The feasibility of automated prediction for COVID-19 infection cure and death rates in the Indian states was demonstrated.
Substance Use and Misuse among Adults with Chronic Obstructive Pulmonary Disease in the United States, 2015–2019: Prevalence, Association, and Moderation
Authors: Alanazi Abdullah M. M. , Alqahtani Mohammed M. , Alquaimi Maher M. , Alotaibi Tareq F. , Algarni Saleh S. , Ismaeil Taha T. , Alanazi Ahmad A. , Alasmari Moudi M. , Alhuthail Eyas A. , Alasmari Ali M , Gibson-Young Linda , Jayawardene Wasantha P.
Published: January 2022

Background: Despite the advancements in chronic obstructive pulmonary disease (COPD) treatment, complications related to COPD exacerbation remain challenging. One associated factor is substance use/misuse among adults with COPD. Fewer studies, however, examined the prevalence and association between COPD and substance use and misuse. In addition, limited knowledge existed about the moderation effects of serious psychological distress and gender among adults with COPD and substance use/misuse. We aimed, therefore, to measure such prevalence, association, and moderation from nationally representative samples in the United States. Method: Data were drawn from the 2015–2019 National Survey on Drug Use and Health. Weighted logistic regressions were used to measure the associations of last-month tobacco (cigarettes, cigars, pipe, and smokeless tobacco products), other licit and illicit substance use (alcohol, marijuana, cocaine, crack, heroin, hallucinogens, and inhalants), and substance misuse (pain relievers, tranquilizers, stimulants, and sedatives) among adults with COPD. Serious psychological distress and gender were tested as moderators in the association between COPD and substance use/misuse. Results: The findings revealed that adults with COPD [Weighted N = 53,115,718) revealed greater odds of cigarettes [adjusted odds ratio (aOR) = 2.48 (95%CI = 1.80–3.42)) and smokeless tobacco (aOR = 3.65 (95%CI = 1.75–7.65)). However, they were less likely to use alcohol (aOR = 0.61 (95%CI = 0.45–0.84)). Adults with COPD who had serious psychological distress were more likely to use pipe tobacco and alcohol; however, they were less likely to use hallucinogens and inhalants. Finally, males compared to females with COPD were less likely to use smokeless tobacco. Conclusion: Adults with COPD in the United States were more likely to use tobacco products and less likely to use alcohol. In addition, serious psychological distress and gender were moderators in associations between COPD and substance use but not in substance misuse. Future studies should longitudinally assess the factors that may contribute to the initiation and progression of substance use and misuse among adults with COPD.
Car Driving Status and Living Arrangement Associated with Sarcopenia among Rural Japanese Older Adults: A Cross-Sectional Study
Authors: Hamano Tsuyoshi , Abe Takafumi , Miyazaki Ryo , Okuyama Kenta , Sundquist Kristina , Nabika Toru
Published: January 2022

Ensuring mobility after driving cessation is an important public health issue to prevent functional limitations, but this issue is still not fully understood in rural settings. The aim of this study was to test the hypothesis that being a non-driver and living alone is associated with a greater risk of sarcopenia among the community-dwelling elderly in rural Japanese areas. This study was conducted in 2018 and data from 738 participants were used. Sarcopenia was assessed by measuring walking speed, handgrip strength, and skeletal muscle mass. Car driving status and living arrangement were collected using self-reported questionnaires and face-to-face interviews. Four groups were set to determine combined conditions of car driving status and living arrangement. Logistic regression analysis was performed to estimate the odds ratio (OR) and a 95% confidence interval of sarcopenia after adjustment for confounding factors. Compared with the reference group (driver and living with others), the OR of sarcopenia was significantly higher in the non-driver and living alone group (OR = 2.21; 95% confidence interval, 1.02–4.80). Our findings suggest that the consideration of both driving status and living arrangement are important in the formulation of public health strategies to prevent sarcopenia in rural Japanese areas.
Nutritional and Other Trace Elements and Their Associations in Raw King Bolete Mushrooms, Boletus edulis
Authors: Falandysz Jerzy
Published: January 2022

The occurrence and associations of Ag, As, Ba, Bi, Cd, Co, Cu, Cs, Hg, Ni, Pb, Rb, Sb, Sr, Tl, U, V, W, and Zn, including data that have not been previously reported on Be, Hf, In, Li, Mo, Nb, Sn, Ta, Th, Ti and Zr, and the sum of (14) rare earth elements (ƩREE), were studied in a spatially diverse collection of the B. edulis caps, stipes, and whole fruiting bodies using a validated procedure with measurement by quadrupole ICP-MS. Toxic Cd and Pb were in B. edulis at concentrations below limits set by the European Union in regulations for raw cultivated mushrooms, while Ag, As, Hg, Sb, Tl, and U, which are not regulated, were at relatively low or typical levels as is usually found in mushrooms from an unpolluted area. The elements Be, Bi, Ga, Ge, Hf, In, Nb, Ta, Th, and W, and also ƩREEs, were found at relatively low concentrations in B. edulis, i.e., with levels from below 0.1 to below 0.01 mg kg−1 dw, and for Ʃ14 REEs, the median was 0.31 mg kg−1 dw. The composite samples of caps showed Ag, Cd, Cu, Cs, Ga, Ge, Hg, Mo, Ni, Rb, Sb, Ti, and Zn at higher concentrations than stipes, while Ba, Co, Hf, Sr, Tl, and Zr were found at higher concentrations in stipes than caps (p < 0.05). Mushrooms were characterized by a low coefficient of variation (CV) of below 20%, between sites for concentrations of As, Cu, Ge, Hg, Ni, V, and Zn, while substantial differences (CV > 100%) were found for Ba, Bi, Co, Hf, Zr, and ƩREEs, and an intermediate variation was found for Sr, W, and U. Principal component analysis performed on mushrooms allowed differentiation with respect to 13 collection sites and separation of a consignment that was specifically contaminated, possibly due to a legacy pollution, with significantly higher levels of Ba, Co, Ga, Li, Nb, Ni, Sr, Th, Ti, Y, Zr, and ƩREEs, and another due to possible recent pollution (Pb-gasoline and also Ni); two due to geological contamination because of the Bi, In, Sc, Sb, Sn, Ta, V and W; and one more, the Sudety Mts. site, which was considered as “geogenic/anthropogenic” due to Ag, As, Be, Cd, Cs, Ni, Pb, Rb, Tl, and U.
Mental Health Problems among COVID-19 Frontline Healthcare Workers and the Other Country-Level Epidemics: The Case of Mexico
Authors: Robles Rebeca , Morales-Chainé Silvia , Bosch Alejandro , Astudillo-García Claudia , Feria Miriam , Infante Sara , Alcocer-Castillejos Natasha , Ascencio Leticia , Real-Ramírez Janet , Díaz Dulce , Gómez-Estrada Héctor Francisco , Becerra Claudia , Escamilla Raúl , López-Montoya Alejandra , Beristain-Aguirre Ana , Vega Hamid , Álvarez-Icaza Dení , Rodríguez Evelyn , Durand Sol , Fresán Ana , Medina-Mora María-Elena , Fernández-Cáceres Carmen , Madrigal de León Eduardo Ángel
Published: January 2022

COVID-19 frontline healthcare workers (FHCW) are struggling to cope with challenges that threaten their wellbeing. We examine the frequency and predictors of the most frequent mental health problems (MHP) among FHCW during the first COVID-19 peak in Mexico, one of the most severely affected countries in terms of FHCW’s COVID-19 mortality. A cross-sectional survey was conducted between May 8 and August 18, 2020. A total of 47.5% of the sample (n = 2218) were FHCW. The most frequent MHP were insomnia, depression, posttraumatic stress symptoms, and health anxiety/somatization (whole sample: 45.7, 37.4, 33.9, and 21.3%; FHCW: 52.4, 43.4, 40.3 and 26.1, respectively). As compared to during the initial COVID-19 phase, depression and health anxiety/somatization symptoms as well as experiences of grieving due to COVID-19, personal COVID-19 status, and having relatives and close friends with COVID-19 were more frequent during the COVID-19 peak. Obesity, domestic violence, personal COVID-19 status, and grieving because of COVID-19 were included in regression models for main FHCW’s MHP during the COVID-19 peak. In conclusion, measures to decrease other country-level epidemics contributing to the likelihood of COVID-19 complications (obesity) and MHP (domestic violence) as well as FHCW´s probability of COVID-19 infection could safeguard not only their physical but also mental health.
Adapting Traditional Healing Values and Beliefs into Therapeutic Cultural Environments for Health and Well-Being
Authors: Marques Bruno , Freeman Claire , Carter Lyn
Published: January 2022

Although research has long established that interaction with the natural environment is associated with better overall health and well-being outcomes, the Western model mainly focuses on treating symptoms. In Aotearoa/New Zealand, the Indigenous Māori have long demonstrated significantly more negative health outcomes than non-Māori. Little research has examined the causes compared to Western populations or the role of the natural environment in health outcomes for Māori. An exploration of rongoā Māori (traditional healing system) was conducted to ascertain the importance of landscape in the process of healing. Eight rongoā healers or practitioners took part in semi-structured narrative interviews from June to November 2020. Transcribed interviews were analysed using an interpretative phenomenological analysis and Kaupapa Māori techniques. The findings show how rongoā is underpinned by a complex set of cultural values and beliefs, drawing from the connection to wairua (spirit), tinana (body), tikanga and whakaora (customs and healing), rākau (plants), whenua (landscape) and whānau (family). Incorporating such constructs into the landscape can foster our understanding of health and well-being and its implications for conceptualising therapeutic environments and a culturally appropriate model of care for Māori and non-Māori communities.
Reliability and Validity of Slovenian Versions of IPAQ-SF, GPAQ, and EHIS-PAQ for Assessing Physical Activity and Sedentarism of Adults
Authors: Meh Kaja , Sember Vedrana , Đurić Saša , Vähä-Ypyä Henri , Rocha Paulo , Jurak Gregor
Published: January 2022

Health policies rely on physical activity (PA) and sedentary behavior data collected through PA questionnaires (PAQs). Validity of international PAQs varies among countries. Therefore, it is important to know the validity of the national versions of the PAQs to properly evaluate the results. We conducted a validation study of the Slovenian versions of the International PAQ Short Form (IPAQ-SF), the Global PAQ (GPAQ), and the PAQ used in the European Health Interview Survey (EHIS-PAQ) on 306 healthy adults. The most valid and reliable constructs in all tested were sedentary behavior and vigorous PA (VPA), however the criterion validity of these constructs was low (Spearman’s ρ 0.38–0.45 for sedentary behavior and 0.34–0.42 for VPA). Moderate to vigorous PA (MVPA) had low validity (0.26–0.29) despite being used as a standard measure of PA behavior. Participants over-reported MVPA for 17 to 156 min and underreported the sedentary behavior for more than two hours. The test-retest study found high reliability for sedentary behavior (0.69–0.81) and low to moderate reliability for PA behavior (0.42–0.76). The Slovenian versions of the observed PAQs are a useful tool for national PA surveillance, but for qualitative assessment of individual health-related PA behavior they should be combined with accelerometer-based devices.