bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of whole seaweed consumption on humans: current evidence from randomized-controlled intervention trials, knowledge gaps, and limitations
Authors: Trigo João P. , Palmnäs-Bédard Marie , Juanola Mar Vall-Llosera , Undeland Ingrid
Published: July 2023

Seaweed is often recognized for its potential health benefits, attributed to its abundance of dietary fibers, protein, and polyphenols. While human observational studies have shown promise, the collective evidence from human intervention trials remains limited. This narrative review aims to comprehensively analyze the effects of seaweed intake on humans, while critically assessing the methodology, including Cochrane risk-of-bias assessment. A search was conducted in online databases, including PubMed, Scopus, and Google Scholar, covering the period from 2000 to May 2023. The focus was on randomized controlled clinical trials (RCTs) evaluating the impact of whole seaweed, either consumed as capsules, integrated into food products or as part of meals. Various health outcomes were examined, including appetite, anthropometric measures, cardiometabolic risk factors, thyroid function, markers of oxidative stress, and blood mineral concentrations. Out of the 25 RCTs reviewed, the findings revealed limited yet encouraging evidence for effects of seaweed on blood glucose metabolism, blood pressure, anthropometric measures, and, to a lesser extent, blood lipids. Notably, these favorable effects were predominantly observed in populations with type-2 diabetes and hypertension. Despite most trials selecting a seaweed dose aligning with estimated consumption levels in Japan, considerable variability was observed in the pretreatment and delivery methods of seaweed across studies. Moreover, most studies exhibited a moderate-to-high risk of bias, posing challenges in drawing definitive conclusions. Overall, this review highlights the necessity for well-designed RCTs with transparent reporting of methods and results. Furthermore, there is a need for RCTs to explore seaweed species cultivated outside of Asia, with a specific emphasis on green and red species. Such studies will provide robust evidence-based support for the growing utilization of seaweed as a dietary component in regions with negligible seaweed consumption, e.g., Europe.
Multi-omics integrated analyzed the origin of intrahepatic mucinous cholangiocarcinoma: a case report
Authors: Zeng Xiaokang , Ou Huohui , Zeng Chong , Liu Qingbo , Wang Weidong , Yao Jie
Published: July 2023

Intrahepatic mucinous cholangiocarcinoma (IMCC) is a rare subtype of intrahepatic cholangiocarcinoma (IHCC). Limited data describe the genetic characteristics of IMCC and insights on its pathogenesis are lacking. Here, we employed a multi-omics approach to analyze somatic mutations, transcriptome, proteome and metabolome of tumor tissue obtained from a case of IMCC in order to clarify the pathogenesis of IMCC. A total of 54 somatic mutations were detected, including a G12D mutation in KRAS that is likely to be involved in the onset of IMCC. The genes consistently up-regulated at the transcription level and in the proteome were enriched for mucin and mucopolysaccharide biosynthesis, for cell cycle functions and for inflammatory signaling pathways. The consistently down-regulated genes were enriched in bile synthesis and fatty acid metabolism pathways. Further multi-omics analysis found that mucin synthesis by MUC4 and MUC16 was elevated by up-regulated expression of mesothelin (MSLN). Moreover, transcription factor ONECUT3 was identified that possibly activates the transcription of mucin and mucopolysaccharide biosynthesis in IMCC.
Identification and comprehensive analysis of epithelial–mesenchymal transition related target genes of miR-222-3p in breast cancer
Authors: Fang Yutong , Zhang Qunchen , Chen Chunfa , Chen Zexiao , Zheng Rongji , She Chuanghong , Zhang Rendong , Wu Jundong
Published: July 2023

Background

Epithelial–mesenchymal transition (EMT) is a crucial mechanism that microRNA-222-3p (miR-222-3p) promotes breast cancer (BC) progression. Our study aimed to identify EMT-associated target genes (ETGs) of miR-222-3p for further analysis of their roles in BC based on bioinformatics tools.

Methods

Based on bioinformatics analysis, we identified 10 core ETGs of miR-222-3p. Then, we performed a comprehensive analysis of 10 ETGs and miR-222-3p, including pathway enrichment analysis of ETGs, differential expression, clinical significance, correlation with immune cell infiltration, immune checkpoint genes (ICGs) expression, tumor mutational burden (TMB), microsatellite instability (MSI), stemness, drug sensitivity, and genetic alteration.

Results

The expression of miR222-3p in basal-like BC was significantly higher than in other subtypes of BC and the normal adjacent tissue. Pathway analysis suggested that the ETGs might regulate the EMT process via the PI3K-Akt and HIF-1 signaling pathway. Six of the 10 core ETGs of miR-222-3p identified were down-expressed in BC, which were EGFR, IL6, NRP1, NTRK2, LAMC2, and PIK3R1, and SERPINE1, MUC1, MMP11, and BIRC5 were up-expressed in BC, which also showed potential diagnostic values in BC. Prognosis analysis revealed that higher NTRK2 and PIK3R1 expressions were related to a better prognosis, and higher BIRC5 and miR-222-3p expressions were related to a worse prognosis. Most ETGs and miR-222-3p were positively correlated with various infiltration of various immune cells and ICGs expression. Lower TMB scores were correlated with higher expression of MUC1 and NTRK2, and higher BIRC5 was related to a higher TMB score. Lower expression of MUC1, NTRK2, and PIK3R1 were associated with higher MSI scores. Higher expression of ETGs was associated with lower mRNAsi scores, except BIRC5 and miR-222-3p conversely. Most ETGs and miR-222-3p expression were negatively correlated with the drug IC50 values. The analysis of the genetic alteration of the ETGs suggested that amplification was the main genetic alteration of eight ETGs except for NTRK2 and PIK3R1.

Conclusion

MiR-222-3p might be a specific biomarker of basal-like BC. We successfully identify 10 core ETGs of miR-222-3p, some might be useful diagnostic and prognostic biomarkers. The comprehensive analysis of 10 ETGs and miR-222-3p indicated that they might be involved in the development of BC, which might be novel therapeutic targets for the treatment of BC.
Learning in the forest: environmental perception of Brazilian teenagers
Authors: Profice Christiana Cabicieri , Grenno Fernando Enrique , Fandi Ana Cláudia , Menezes Stela Maria , Seminara Cecília Inés , Cassano Camila Righetto
Published: July 2023

The idea of separation between person and nature, accentuated by current production and consumption models, has generated unthinkable impacts, causing an unprecedented loss and degradation of the global environment. Occupying 13% of the Brazilian territory, the Atlantic Forest is the second-largest tropical rainforest on the American continent; however, it is one of the most threatened biomes in the world, with only 12% of the original cover. In this study, we consider that enabling young people to experience direct contact with nearby natural environments can positively influence their knowledge and feelings about the biodiversity that occurs there, contributing to its protection and conservation for current and future generations. In this study, we explore how teenagers (n = 17) aged between 13 and 17 years old describe and perceive the nearby natural environment before and after an interpretive trail in Una, Bahia, Brazil. Participants were asked to draw the Atlantic Forest with colored pencils on white paper and, based on the drawing, they answered the following questions: “What is in your drawing? and “What is happening in your drawing?,” in addition to other information such as the title of the drawing, difficulty of the activity, and sociodemographic aspects. Content analysis was used to analyze the information collected. From the drawings and responses of the participants, categories related to knowledge, experiences, and types of relationships with the visited place emerged. We count the frequency of drawing elements before and after the visit, together with a qualitative analysis of the descriptions of their feelings and meanings attributed to the visit, highlighting the different elements and their relationships. The results showed that, after the trail, the participants manifested bonds of proximity with the visited environment and the organisms protected there, evidencing expressive changes in their perceptions of the person-nature interaction, in the specific knowledge of the visited ecosystem, and in the different forms of relationship provided by the visitation itinerary.
Adding physical activity to intensive trauma-focused treatment for post-traumatic stress disorder: results of a randomized controlled trial
Authors: Voorendonk Eline M. , Sanches Sarita A. , Tollenaar Marieke S. , Hoogendoorn Elisabeth A. , de Jongh Ad , van Minnen Agnes
Published: July 2023

Introduction

This randomized controlled trial examined the effectiveness of physical activity added to an intensive trauma-focused treatment (TFT) for post-traumatic stress disorder (PTSD) in comparison to adding non-physical control activities.

Methods

A total of 119 patients with PTSD were randomly assigned to a physical activity condition (PA; n = 59) or a non-physical activity control condition (nPA; n = 60). The 8-day intensive TFT programme consisted of daily prolonged exposure, EMDR therapy, and psychoeducation, which was complemented with physical activities versus controlled mixtures of guided (creative) tasks. As a primary outcome, the change in clinician and self-reported PTSD symptoms from pre-to post-treatment and at 6 months follow-up were measured.

Results

Intent-to-treat linear mixed-effects models showed no significant differences between the PA and nPA conditions on change in PTSD severity. Clinician and self-reported PTSD symptoms significantly decreased for both conditions, with large effect sizes (e.g., CAPS-5 dpre-post = 2.28). At post-treatment, 80.0% in the PA, and 82.7% in the nPA condition no longer met the diagnostic criteria for PTSD. Regarding the loss of Complex PTSD diagnoses this was 92.5% and 95.0%, respectively.

Conclusion

Either with additional physical or non-physical activities, intensive TFT is very effective for the treatment of (Complex) PTSD, as reflected by large effect sizes and loss of diagnostic status in both groups.

Clinical trial registration

Trialregister.nl Identifier: Trial NL9120.
Effects of green space on physical activity and body weight status among Chinese adults: a systematic review
Authors: Song Yiling , Li Haoxuan , Yu Hongjun
Published: July 2023

Background

Green space may provide many benefits to residents’ health behaviors and body weight status, but the evidence is still relatively scattered among Chinese adults. The purpose of this study was to review the scientific evidence on the effects of green space on physical activity (PA) and body weight status among Chinese adults.

Methods

A keyword and reference search was conducted in Pubmed, Web of Science, MEDLINE, and PsycINFO. Studies examining the associations between green space and PA, body mass index (BMI) among Chinese adults were included. The quality of the included literature was evaluated using the National Institutes of Health’s Observational Cohort and Cross-Sectional Study Quality Assessment Tool.

Results

A total of 31 studies were included that met the inclusion criteria, including 25 studies with a cross-sectional design, 3 studies with a longitudinal design, and 3 studies with an experimental design. Street-level green view index and green space accessibility were found to be positively associated with PA, but negatively associated with BMI. In most studies, there was a correlation between green space ratio in local areas and BMI. In addition, green space interventions were effective in increasing PA and decreasing BMI among Chinese adults. In contrast, further evidence is needed to support the association between the design characteristics of green space and PA and BMI.

Conclusion

Preliminary evidence suggests that green space has a positive effect on PA and BMI among Chinese adults. However, there are contradictory findings, and future studies adopting longitudinal and quasi-experimental studies are needed to further explore the causal relationship between green space and PA and BMI to provide a relevant theoretical basis for policymakers.
Filling the gaps: A community case study in using an interprofessional approach and community-academic partnerships to address COVID-19-related inequities
Authors: Kutchma Marisa L. , Perez Julianna , Stranges Elizabeth , Steele Kellie , Garis Tayler , Prost Anastazia , Siddiqui Sumbul , Choo-Kang Candice , Shaul Bonnie , Benissan Dede Golda Gbikpi , Smith-Haney Gwendylon , Mora Nallely , Watson Maya , Griffith Thao , Booker Nathaniel , Harrington Amanda , Mitchell L. Kate , Blair Amy , Luke Amy , Silva Abigail
Published: July 2023

Public health challenges rapidly escalated during the COVID-19 pandemic. In response to a severe lack of resources and support in the near western suburbs of Chicago, the COVID Equity Response Collaborative: Loyola (CERCL) was established by an interprofessional team of Loyola University Chicago students, staff, and faculty. CERCL sought to minimize the negative impact of COVID-19 on vulnerable communities, those that are largely Black, Hispanic, or low-income. From April 2020 to the present, the collaborative utilized community-academic partnerships and interdisciplinary collaborations to conduct programming. CERCL’s programming included free community-based testing, screening for and assistance with social determinants of health, dissemination of relevant and reliable COVID-related information, provision of personal protective equipment, and facilitation of access to vaccines. With partners, the collaborative conducted 1,500 COVID-19 tests, trained 80 individuals in contact tracing, provided over 100 individuals with specifically tailored resources to address social and legal needs, distributed 5,000 resource bags, held 20 community conversations, canvassed 3,735 homes, and hosted 19 vaccine clinics. Community-academic partnerships with the health system, community and governmental agencies, and the local public health department have been critical to CERCL efforts. The interdisciplinary and interprofessional successes demonstrated in this case study lends the example of a relevant, sustainable, and practical intervention to address nuanced public health issues.
Current situation, bottlenecks, and path options for the development of capital flows and integration in the Yangtze River Delta region
Authors: Yang Jing , Li Guofan , Zhong Zhuowen , Li Qiang , Du Guolei , Guo Jinhan
Published: July 2023

Introduction

Capital plays a crucial role in the development of regional economies, especially in low-income regions where it acts as a primary driver of economic growth. Efficient capital flow is essential for optimizing resource allocation and facilitating the development of integrated capital markets. This passage introduces the topic of capital, capital flow, and capital market integration and highlights their significance in regional development.

Methods

To gain a comprehensive understanding of capital flow and integration in the Yangtze River Delta region, the researchers conducted a connotative analysis. They constructed indicators from various aspects, including social fixed asset investment, bank capital flow, government transfer payments, social financing structure, and foreign direct investment. By utilizing these indicators, the researchers aimed to assess the current situation and identify bottlenecks related to capital flow and integration. Additionally, they drew on experiences from foreign capital flow and integration development to enrich their analysis.

Results

The analysis revealed several primary bottlenecks affecting capital flow and integration in the Yangtze River Delta region. These bottlenecks include an unsound banking management system, the presence of government competition and administrative barriers, and shortcomings within listed companies. The results highlight the specific challenges that hinder the smooth functioning and integration of capital in the region.

Discussion

To promote the development of capital flows and integration in the Yangtze River Delta region, the researchers propose various recommendations. These suggestions include promoting the development of listed companies, establishing a robust banking management model, improving relevant government policies, and optimizing the investment environment. These recommendations serve as important guidelines for policymakers to enhance capital flow and integration in the Yangtze River Delta city cluster. Furthermore, they emphasize the need to strengthen financial supervision and improve institutional mechanisms within the three provinces and one city comprising the region.
Incorporation of molecular hydrogen into solvents increases the extraction efficiency of phenolics, flavonoids, anthocyanins, and antioxidants: the case of lemon peels
Authors: Alwazeer Duried , Elnasanelkasim Muhammed Allam , Çiğdem Ayhan , Engin Tunahan , LeBaron Tyler W.
Published: July 2023

The impact of hydrogen infusion into solvents on the extraction of phytochemicals was evaluated. Pure (water, ethanol, methanol) and hydrogen-rich solvents at temperatures (25°C and 35°C) were used for extracting phenolics, flavonoids, anthocyanins, and antioxidants from lemon peel. Incorporating hydrogen into all solvents increased the extraction of all phytochemicals. The hydrogen incorporation into solvents led to the highest increase in phenolics and flavonoid contents shown for hydrogen-rich methanol (HRM) followed by hydrogen-rich ethanol (HRE) at both 25°C and 35°C. The highest antioxidant extraction was shown for HRM. The hydrogen incorporation showed the highest phytochemical extraction in methanol and at 35°C. The increase in temperature increased the extraction efficiency, but less efficiently than the hydrogen incorporation. The HPLC phenolic profile confirmed the positive effect of both temperature and hydrogen incorporation on the extraction of flavonoids and non-flavonoids. The improvement of the phytochemical extraction by the proposed method can bring many economic and ecological advantages.
Cu(II)/Polydopamine-Modified Glass Fiber Separators for High-Performance Zinc-Ion Batteries
Authors: Ma Fengcan , Xie Kaixuan , Wu Siheng , Zhang Chi , Liao Xiaodie , Wang Qinghong
Published: July 2023

Much attention has been given to aqueous zinc-ion batteries (ZIBs) due to their features of inherent safety, environmental compatibility, low cost, and fantastic energy density. Nevertheless, chemical corrosion and dendrite growth occurring on Zn anodes during the charge–discharge process, which often cause surface passivation and short circuit of cells, seriously hindering the development of ZIBs. To solve these problems, a Cu(II) and polydopamine co-modified glass fiber (Cu(II)-PDA/GF) is designed as separator. On one hand, the modification of PDA enhances ionic conductivity and the water absorbing capability of a glass fiber separator due to the presence of functional groups. On the other hand, the pre-deposition of Cu on Zn anodes enables the uniform nucleation of Zn during the initial deposition process. Due to the synergistic effect, reversible zinc plating/striping is achieved in symmetric cells, which display a long lifecycle of over 1800 h at the current density of 1 mA cm−2 and with a fixed capacity of 1 mAh cm−2. Moreover, the assembled Zn//V2O5 cells using the Cu(II)-PDA/GF separator also demonstrate improved capacity retention. This study provides a simple and effective separator modification strategy for high-performance and reliable ZIBs, which are conducive to other metal-based energy storage devices.
Preliminary Adaptation of Motor Tests to Evaluate Fine Motor Skills Associated with Mathematical Skills in Preschoolers
Authors: Flores Pedro , Coelho Eduarda , Mourão-Carvalhal Maria Isabel , Forte Pedro M.
Published: July 2023

Mathematics is the subject in which many school-age children reveal difficulties. The literature has shown that fine motor skills, namely fine motor coordination and visuomotor integration, have been more robustly associated with mathematical performance. Studies have shown the importance that instruments have to evaluate these skills, however, the characteristics of these instruments do not fit the reality of kindergartens, they are usually time consuming and expensive and are usually administered by specialists. Thus, the main objective of this study was to identify, select, adapt and validate motor tests to evaluate fine motor skills associated with mathematical skills to allow the kindergarten teachers to apply them simultaneously to the class, with few material resources, in a short period of time and without the need for a lot of training to apply, score and classify. For this purpose, firstly, it was necessary to understand the main difficulties highlighted by kindergarten teachers regarding the use of instruments to evaluate fine motor skills and, thus, elaborate criteria to identify and select the tests that best fit the reality of kindergartens. The test identified, selected and adapted to evaluate fine motor coordination was threading beads from the Movement Evaluation Battery for Children, 2nd Edition. The main adaptation of the test was related to time, that is, instead of counting the time it takes the child to string the total number of cubes on the string, we counted the number of cubes the child strung on the string in a pre-defined time. To evaluate visual–motor integration, the test identified, selected and adapted was the Visual–Motor Integration (6th Edition) test. The main adaptation was related to material resources, that is, it will be possible to apply the test using only one sheet per child instead of the seven suggested by the original test. After the preliminary adaptation of the tests, their validation was performed by means of the degree of reliability (test-retest) and predictive validity. The results indicated that the adapted tests presented an excellent degree of reliability (>0.9) and could therefore be used to administer them simultaneously to the class group. The adapted Visual–Motor Integration test seems to be the most suitable one to be used by kindergarten teachers, in a classroom context, to simultaneously evaluate students’ fine motor skills and associate their results with mathematical skills.
Analysis of Couples’ Discordance on Fertility Desire in Ghana
Authors: Yeboah Isaac , Okyere Joshua , Duah Henry Ofori , Conduah Andrew Kweku , Essiaw Mary Naana
Published: July 2023

Generally, men in sub-Saharan Africa make reproductive decisions that affect their partners. We examined the predictors of fertility desires among married men across three age cohorts: 20–35 years, 36–50 year, and 51–59 years. Using the 2014 Ghana Demographic and Health Survey dataset, we conducted ANOVA and multivariate binary logistic regressions on 1431 monogamous married men aged 20–59 years. Two indicators of fertility desire are constructed: (i) the comparison of men’s ideal versus women’s ideal family size, and (ii) the desire for more children. The results indicate that the fertility desire of men is stronger than that of women. The predictors of fertility desire are age, parity, religion, contraceptive use, wealth quintile, couples’ age difference and couples’ difference in education. At ages 20–35 years, men using modern contraceptives were more likely to desire more children compared with those not using any modern contraceptives. However, at ages 36–50 years, men using modern contraceptives were less likely to desire more children. This finding suggests that men change their fertility desires in response to changes in their ages.
IgM-Associated Cryoglobulinaemia
Authors: Khwaja Jahanzaib , Salter Simon J. , D’Sa Shirley
Published: July 2023

Cryoglobulinaemia is characterised by serum immunoglobulins that precipitate at temperatures below 37 °C and redissolve on warming. Monoclonal IgM immunoglobulin can be associated with type I and II cryoglobulinaemia with underlying Waldenström macroglobulinemia, monoclonal gammopathy of undetermined significance, or another non-Hodgkin lymphoma. In this research, we review the clinical characteristics of monoclonal IgM-associated cryoglobulinaemia and suggest a management approach for addressing them. Laboratory testing is critical as even a minimal amount of measurable cryoglobulin may result in symptoms. Accurate detection of cryoglobulins may be challenging, care must be taken with preanalytical variables, and repeated testing of monoclonal protein and cryoglobulins is indicated if clinical suspicion is high. Presentations range from asymptomatic to showing multisystem involvement, meaning that careful evaluation of the features and a thorough interrogation of organ systems and the underlying clone are critical. Immediate management is required for clinical red-flag features. Due to their rarity, data to inform treatment decisions are scant and collaborative research is imperative must be conducted to aid researchers in efforts to define optimal treatment strategies.
Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease
Authors: Hu Yunwen , Cai Zhaohua , He Ben
Published: July 2023

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of the aorta, which plays a critical role in the maintenance of aortic wall integrity. VSMCs have been suggested to have contractile and synthetic phenotypes and undergo phenotypic switching to contribute to the deteriorating aortic wall structure. Recently, the unprecedented heterogeneity and diversity of VSMCs and their complex relationship to aortic aneurysms (AAs) have been revealed by high-resolution research methods, such as lineage tracing and single-cell RNA sequencing. The aortic wall consists of VSMCs from different embryonic origins that respond unevenly to genetic defects that directly or indirectly regulate VSMC contractile phenotype. This difference predisposes to hereditary AAs in the aortic root and ascending aorta. Several VSMC phenotypes with different functions, for example, secreting VSMCs, proliferative VSMCs, mesenchymal stem cell-like VSMCs, immune-related VSMCs, proinflammatory VSMCs, senescent VSMCs, and stressed VSMCs are identified in non-hereditary AAs. The transformation of VSMCs into different phenotypes is an adaptive response to deleterious stimuli but can also trigger pathological remodeling that exacerbates the pathogenesis and development of AAs. This review is intended to contribute to the understanding of VSMC diversity in health and aneurysmal diseases. Papers that give an update on VSMC phenotype diversity in health and aneurysmal disease are summarized and recent insights on the role of VSMCs in AAs are discussed.
Structural Performance Improvement of Reinforced Concrete Beams by Strain-Hardening Cementitious Composite Layers
Authors: Khan M. Iqbal , Sial Sardar Umer , Abbas Yassir M. , Fares Galal
Published: July 2023

A strain-hardening cementitious composite (SHCC) is a modern engineered material offering exceptional ductility and durability. A potential application of SHCCs for crack control and to improve structural members’ load-bearing capabilities is due to its superior properties. In this study, SHCCs were used to enhance the load-carrying capacity and the cracking behavior of precast RC beams. In the bottom tension region of RC beams, the SHCCs of different layer thicknesses (0%, 15%, 30%, and 45% of section height) were cast. Laboratory-scale beams were used in 4-point bending tests. SHCC-layered RC beams showed improved flexural performance compared to control RC beams. Among retrofitted beams, the one with an SHCC layer of 30% of the section height was found to be the most efficient pertaining to strength, ductility, and cracking control. In this study, the flexural response of composite beams was also predicted using an analytical approach. The average difference between predicted and measured moment capacities was less than 10%.
Design Strategies Toward Plasmon-Enhanced 2-Dimensional Material Photodetectors
Authors: Li Ke-Han , Chen Xia-Yao , Su Dan , Song Yuan-Jun , Zhou Huan-Li , Liu Zhao-Guo , Xia Peng , Zhang Xiao-Yang
Published: July 2023

Two-dimensional (2D) materials have become more advantageous compared with traditional semiconductor materials for fabrication of modern photodetectors operating at room temperature and possessing small volume and low power consumption. However, the weak absorption caused by atomic thickness severely limits the performance of photodetectors employing 2D materials as active channels. Plasmonic nanomaterials can manipulate light at subwavelength scale and have been viewed as a powerful tool to achieve enhanced photoresponse in semiconductor devices. In this review, the rational design strategies of plasmon-enhanced 2D material photodetectors are comprehensively introduced, where the hybrid nanostructures are classified based on different coupling modes between plasmonic nanostructures and 2D materials. This review has a great chance to provide an instructive reference for understanding and engineering plasmonic effects toward high-performance 2D material photodetectors.
User stories as a tool for the specification of requirements: institutional projects and skills development
Authors: HERNÁNDEZ-CRUZ Luz María , CHUC-CAAMAL Nardin Alexander , LLANES-CHIQUINI Charlotte Monserrat , MEX-ALVAREZ Diana Concepción
Published: July 2023

This article presents a study that aims to promote the success of software development projects using the agile approach efficiently in the requirements specification stage. The objective of the research is to implement as a strategy the definition of User Stories proposed by the agile approach. The case study presents the academic project "Acanmul", a comprehensive solution developed with emerging technological tools that lead to easy access and availability of tourist information from the state of Campeche, Mexico. During the development of the Acanmul software product, the implementation and start-up of the roles, artifacts, events, tools and techniques provided by the Scrum framework that ensure the agile management of the project during its execution and, in addition, favor the development of generic and disciplinary competencies in the area of project management. In this way, it is ensured that the development of the Acanmul software can collect and determine the specific requirements of the own needs for the reactivation of social, economic and commercial processes in the state and, therefore, in the country.
Confirmation de l’exclusion de la prise en compte de l’état antérieur provoqué ou révélé par le fait dommageable dans l’indemnisation de la victime
Authors: Vincent Émilie
Published: July 2023

La Cour de cassation confirme sa position, de jurisprudence constante, selon laquelle le droit de la victime à l’indemnisation de son préjudice corporel ne saurait être réduit en raison d’une prédisposition pathologique, c’est-à-dire un état antérieur, lorsque l’affectation qui en est résulté n’a été provoquée ou révélée que par le fait dommageable.
COVID-19 in patients with congenital bleeding disorders in Russia
Authors: Yakovleva E. V. , Vybornykh D. E. , Gemdzhian E. G. , Zozulya N. I.
Published: July 2023

Background. Internationally published data about the course of COVID-19 in patients with congenital bleeding disorders (CBDs) are limited. There are questions about how COVID-19 affects the course of CBDs and, conversely, how CBDs affect the course of coronavirus infection.

Aim — to analyze the course of COVID-19 in patients with CBDs in Russia.

Materials and methods. A cross-sectional survey was conducted at the National Medical Research Center for Hematology (Moscow) for the period from June 25 to July 31, 2022. A cluster of 187 patients from different regions and cities of Russia were interviewed with a questionnaire based on survey administration software (Google forms) containing 27 questions.

Results. COVID-19 affected 115 (62 %) of 187 surveyed patients and 22 (19 %) patients suffered from coronavirus infection twice. Hospitalization was required for 14 (12 %) patients with an average age of 42 years (10 patients with severe hemophilia A, 1 patient with moderate hemophilia B, 2 patients with von Willebrand disease and 1 patient with hypoproconvertinemia). During COVID-19 bleeding was observed in 9 (8 %) patients and was represented by hemarthrosis, ecchymosis, hematomas, nosebleeds, menorrhagia, hemorrhoidal bleeding, hemorrhage in the eyeball. There were no cases of thrombosis among 115 COVID-19 patients. Among patients with CBDs who had COVID-19, compared with patients who had not COVID-19, von Willebrand disease was statistically significantly more common (p = 0.04). Changes in the course of CBD after COVID-19 were noted by 21 (18 %) of 115 patients: 11 (10 %) of those who were ill noted increased joint pain, 9 (8 %) complained of joint pain that had not been previously experienced; 10 % of patients described changes of hemorrhagic syndrome.

Conclusion. The probability of hospitalization of patients with CBDs and COVID-19 older than 40 is statistically significantly higher. Von Willebrand disease can be considered as a potential risk factor for COVID-19. Given the absence of cases of thrombosis in the interviewed group of patients, the results of the study suggest that the presence of hypocoagulation in patients with CBDs may be a protective pathophysiological mechanism that prevents the development of COVID-19-associated thrombotic complications.
Mandatorio: significato, storia, usi
Authors: Fusco Francesca
Published: July 2023

Alcuni lettori chiedono chiarimenti in merito all’aggettivo mandatorio usato con il senso di ‘obbligatorio’: se è ammissibile nella lingua italiana, se è proprio solo di determinati linguaggi specialistici, e se deriva dall’inglese mandatory.
PREVALÊNCIA E FATORES ASSOCIADOS AO CONSUMO ABUSIVO DE ÁLCOOL NO BRASIL
Authors: Barros Sofia Almeida da Silveira , Torres Priscilla Evellin de Azevedo , Oliveira Isabeli Gomes de , Leandro Mayara dos Santos , Freitas Alessandra Santos de , Delgado Adriana Farto Viana , Alineri Thalita Pinheiro Morel , Vivas Alexandre Dayrell , Catarino Riala Caroline Cheloni , Freitas Alessandra Santos de , Rodrigues Heloise Baldan Otero , Cunha Isabela Maria Morais da , Oliveira Isabeli Gomes de , Lamarca João Pedro , Santos Larissa Oliveira dos , Nascimento Filho Manoel Alves do , Vilarinho Cindy Alves , Bezerra Thiago Augusto Rocheti , Silva Priscila Andrade Ranéia e
Published: July 2023

Introdução: O consumo de álcool é um comportamento difundido na cultura e nas famílias brasileiras. O centro de informações sobre Drogas Psicotrópicas (CEBRID), trouxe dados de uma enquete domiciliar realizada em 108 cidades brasileiras com mais de 200 mil habitantes. Objetivo: Realizar um estudo transversal a respeito do consumo abusivo de álcool na população adulta Brasileira entre os anos de 2010 a 2023. Material e Métodos: Trata-se de um estudo observacional, do tipo transversal cuja população alvo foi o público o público adulto Brasileiro consumidor de álcool em excesso, entre os anos de 2010 a 2023. Resultados: A frequência de consumo abusivo de bebidas alcoólicas (ingestão de quatro ou mais doses, para mulheres, ou de cinco ou mais doses, para homens, em uma mesma ocasião, pelo menos uma vez nos últimos 30 dias anteriores à data da pesquisa) aumentou no período entre 2010 e 2023, variando de 15,7%, em 2010, a 20,9% em 2023, (aumento médio de 0,22 pp/ano). Esse aumento foi observado entre mulheres, variando de 7,8%, em 2010, a 16,0% em 2023 (0,44 pp/ ano). Considerações Finais: Os dados a respeito do consumo de álcool na população Brasileira são alarmantes. Campanhas de incentivo a diminuição do consumo devem ser feitas corroborando para e diminuição do consumo.
FISIOPATOLOGIA DA DOENÇA DE ALZHEIMER E A IMPORTÂNCIA DA REDE DE APOIO NO TRATAMENTO DO PACIENTE IDOSO
Authors: Alineri Thalita Pinheiro Morel , Delgado Adriana Farto Viana , Beloto Cristiana do Nascimento Oliveira , Oliveira Brenda Maria Mendes Rodrigues de , Santos Simone Gomide dos , Guion Silvia de Oliveira , Farias Gabriella Cristina Alves da Silva Rodrigues , Vilarinho Cindy Alves , Barros Sofia Almeida da Silveira , Torres Priscilla Evellin de Azevedo , Oliveira Isabeli Gomes de , Leandro Mayara dos Santos , Freitas Alessandra Santos de , Cruz Ana Carolina Correia , Rodrigues Heloise Baldan Otero , Bezerra Thiago Augusto Rochetti , Silva Priscila Andrade Ranéia e
Published: July 2023

A Doença de Alzheimer (DA) é designada como uma síndrome cerebral degenerativa, de etiologia desconhecida, com componentes neuropatológicos, neuroquímicos distintos e cognitivos, a qual a tendência é tornar-se ainda mais significativo de acordo com o passar dos anos, e vão além da biologia do envelhecimento, e que se desdobram em mudanças sociais, interferindo na vida pessoal e familiar, resultando em alterações severas de autonomia e independência, impossibilitando a realização de atividades instrumentais básicas da vida diária, e apresenta-se como a forma mais comum de demência em idosos. O papel de cuidar possui relação direta com o estresse, visto que promove impactos na saúde, no equilíbrio familiar e na qualidade de vida daqueles que o realizam, ao passo que também ocasiona reflexos sobre a aceitação da condição do paciente e o cuidado a ser desenvolvido. Desta forma, os comprometimentos que afetam os cuidadores e familiares de idosos com DA, necessitam de atenção, visto que a qualidade de vida destes podem gerar reflexos diretos sobre o cuidado dos portadores da doença, demonstrando a necessidade de cuidar de quem cuida. Este artigo teve como objetivo verificar através de estudos e dados publicados sobre a Fisiopatologia e a importância da rede de apoio familiar no tratamento do paciente idoso com Alzheimer.
Riesgo de enfermedades silenciosas por contaminación de heces de Columba Livia
Authors: Orellana Aguilar María Lorena , Flores Lobo Cristian , Rocha Hernandez Brandon , Irusta Conde Emanuel Fernando , Mamani Rosas Ana María , Calizaya Cartagena Telma Cecilia
Published: July 2023

Introducción: La gran cantidad de Columbia Livia y la preocupación de salud pública sobre estas aves, han llevado a que se las considere una plaga por los problemas como la propagación de enfermedades, la contaminación ambiental y la degradación de la infraestructura. Algunas enfermedades se propagan a través de la contaminación fecal, por lo tanto, la finalidad del estudio fue identificar microorganismos que se encuentran en las heces de la Columbia Livia, que están contacto indirecto con los estudiantes de un campus universitario; además de establecer el conocimiento y percepción de los estudiantes respecto a la Columbia Libia. Metodología: El estudio es cuantitativo, descriptivo, de cohorte transversal y prospectivo; las muestras de heces corresponden a 23 muestras y la población estudiantil encuestada fueron 224; las técnicas utilizadas en el estudio fueron la observación y la encuesta que fue en línea. Se realizó el procedimiento en nueve etapas para la identificación y registró de los microorganismos. Resultados: De 100 % de muestras obtenidas de hisopado rectales de la Columbia Livia, 67 %, se evidenció presencia de Bacterias Gram Negativas (Salmonela); mientras que, en heces secas, se reporta presencia de hongos tabicados en un 50 %; en relación con los conocimientos y la percepción cuáles 64,3 % (N=144) saben que es y en relación con la transmisión la percepción de los estudiantes es 59,8 %, creen que puede transmitir enfermedades por contacto Indirecto. Discusión: Por lo tanto, es importante aplicar medidas de control y prevención y así poder evitar problemas en la población que se encuentra expuesta.
Teachers’ Challenges in Promoting Learner Autonomy
Authors: Marzuki Marzuki , Indrawati Inda , H Ismail Yunus
Published: July 2023

: The concept of learner autonomy has garnered significant attention from scholars, educators, policy makers, and researchers across various countries. However, In Indonesia, the body of research dedicated to learner autonomy is still growing, with specific attention needed to identify potential obstacles that might deter its promotion. This study, therefore, aims to delve into the socio-cultural challenges encountered by secondary school teachers when fostering learner autonomy.This investigation is crucial, as socio-cultural influences appear to be a significant barrier for English as a Foreign Language (EFL) students in Indonesia. The study adopted a qualitative descriptive research approach, utilizing a purposive sampling technique to select participants based on specific criteria. These included senior high school teachers with over five years of experience at their respective schools, who were also willing to participate in interviews. In total, six English teachers from different senior high schools within a single Indonesian province contributed to this study. The data were collected through semi-structured interviews, and the teachers' responses were quoted and interpreted in light of the data analysis and supporting theories from relevant literature. The findings revealed three primary socio-cultural barriers impeding the promotion of learner autonomy: (1) barriers due to language issues, (2) barriers related to a limited worldview, and (3) institutional barriers. This research implies that promoting learner autonomy in language learning requires adjustments in teaching strategies, curriculum design, and institutional policies. Research suggestions are also provided to further research to address the limitation of the current study.

 

Keywords: Challenges, Learner Autonomy, Socio-Cultural Barriers
The Finnish Reproducibility Network (FIRN): A national bottom-up approach to scientific integrity in a global context
Authors: Voikar Vootele , Casarotto Plinio , Glerean Enrico , Laakso Kati , Saurio Kaisa , Karhulahti Veli-Matti , Scherer Andreas
Published: July 2023

Across sciences the lack of reproducibility has raised concerns that shake disciplinary foundations. In this article, the need for institutional solutions as one possible antidote to reproducibility issues is suggested, and Reproducibility Networks (RNs), as a case in point, are explained. In particular, we reflect on the establishment of the Finnish RN as part of a growing international network of RNs, and outline a bottom-up approach, which aims at helping to overcome the reproducibility crisis by distributing awareness of ethical, practical, and other domains of relevant knowledge in places where the future of science is being made: the pedagogical structures of research institutions and societies.
THE INFLUENCE OF WORKLOAD, CAREER DEVELOPMENT, AND COMPENSATION ON TURNOVER INTENTION AT PT PRIMA UFUK SEMESTA
Authors: Kurniawan Prasetyo , Solihin Dede
Published: July 2023

This study aims to examine and analyze the effect of workload, career development, and compensation on turnover intention at PT Prima Ufuk Semesta. The population in this study were all employees of PT Prima Ufuk Semesta. The sampling technique was saturated sampling so that a total sample of 60 respondents was obtained. The research was conducted by distributing questionnaires. The analytical method uses the Structural Equation Model (SEM) approach with the Smart PLS 3.0 analysis tool. The results of the study show that workload has a positive and significant effect on turnover intention. This can be interpreted that the higher the workload received by employees will be able to increase employee turnover intention. Career development has a negative and significant effect on turnover intention. This can be interpreted that the higher the career development received by employees will be able to reduce employee turnover intention. Compensation has a negative and significant effect on turnover intention. This can be interpreted that the higher the compensation received by employees will be able to reduce employee turnover intention.
ANALYSIS OF ONLINE TRANSPORTATION CUSTOMER SATISFACTION IN VIEW FROM BRAND IMAGE, E-SERVICE QUALITY AND SECURITY FACTORS
Authors: Hanika Ita Musfirowati , Nani Nani , Widowati Dyah , Sudirman Acai
Published: July 2023

Transportasi online telah menjadi bagian penting dari kehidupan sehari-hari banyak orang di era digital saat ini. Kepuasan konsumen dalam penggunaan transportasi online menjadi faktor kritis yang memengaruhi pertumbuhan dan kesuksesan platform-platform tersebut. Tujuan utama peneliti ini untuk menganalisis pengaruh brand image, e-service quality, dan faktor keamanan terhadap kepuasan konsumen pengguna transportasi online Sampel dalam penelitian ini berjumlah 150 pengguna transportasi online yang ditentukan dengan pendekatan convenience sampling. Analisis data menggunakan aplikasi SPSS dengan menampilkan hasil pengolahan data melalui uji instrumen penelitian dengan uji validitas dan reabilitas, analisis regresi berganda, koefisien determinasi dan uji hipotesis. Berdasarkan hasil analisis data menyimpulkan brand image, e-service quality, dan keamanan berpengaruh positif dan signifikan terhadap kepuasan konsumen. Implikasi penelitian menginformasikan kepuasan konsumen dapat membantu identifikasi kekurangan dalam layanan pelanggan pada platform transportasi online. Penelitian ini dapat menyoroti area-area di mana konsumen mengalami kesulitan atau ketidakpuasan, seperti respons lambat terhadap pertanyaan atau keluhan, atau kurangnya dukungan pelanggan yang memadai dari platform transportasi online. Online transportation has become an important part of the daily life of many people in today's digital era. Consumer satisfaction in using online transportation is a critical factor influencing the growth and success of these platforms. The main objective of this research is to analyze the effect of brand image, e-service quality, and safety factors on consumer satisfaction with online transportation users. The sample in this study was 150 online transportation users who were determined by a convenience sampling approach. Data analysis uses the SPSS application by displaying the results of data processing through research instrument tests with validity and reliability tests, multiple regression analysis, coefficient of determination and hypothesis testing. Based on the results of data analysis concluded that brand image, e-service quality, and security have a positive and significant impact on customer satisfaction. The research implications of informing consumer satisfaction can help identify deficiencies in customer service on online transportation platforms. This research can highlight areas where consumers experience difficulty or dissatisfaction, such as slow responses to inquiries or complaints, or lack of adequate customer support from online transportation platforms