bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploiting a Lattice-Driven Gating in a Cu-Based Zeolitic Imidazolate Framework for Efficient High-Temperature Hydrogen Isotope Separation
Authors: Oh Hyunchul , Jung Minji , Park Jaewoo , Muhammad Raeesh , Park Taeung , Yi Jungwon , Jung Cheolwon , Ollivier Jacques , Ramirez-Cuestae Anibal J. , Park Jitae , Kim Jaheon , Russina Margarita
Published: August 2024

This study presents a novel approach for hydrogen isotope separation using Cu-ZIF-gis, a Cu-based zeolitic imidazolate framework with ca. 2.4 Å channels. Traditional Kinetic Quantum Sieving(KQS) method involves exploiting diffusion barriers, caused by the flexibility of local linker molecules or unit cell breathing phenomena. However, these methods are ineffective at high temperatures, as such opening transition typically completes below 77K. Cu-ZIF-gis leverages a new approach named "Lattice-driven gating", which uses lattice expansion to control the aperture at elevated temperatures up to 180K. Despite the lack of strong binding sites, it achieves effective isotope uptake via KQS above 120K and shows exceptional stability, remaining intact for nearly 3 years in air. With the help of Quasi-Elastic Neutron Scattering(QENS), we observe substantial differences in the molecular mobility of H2 and D2 above 150K. This method is compatible with existing LNG cryo-infrastructure, marking a significant advancement in sustainable isotope separation technologies.
Cost-effectiveness and societal burden implications of screening for fracture risk in a UK general radiography setting
Authors: Söreskog Emma , Lopez Ben , Bean Thomas , Lewis Penny , Ashley Nicholas , Lopes Joanita Da Palma , Meertens Robert , Ratcliffe Adam
Published: August 2024

Background
Fragility fractures lead to considerable societal costs and individual suffering. Despite the availability of cost-effective treatments for high-risk patients, a significant treatment gap exists, with many high-risk individuals remaining unidentified and untreated. The aim of this study was to evaluate the cost-effectiveness and societal impact of opportunistic screening for fracture risk with IBEX Bone Health (BH), a software solution that provides bone mineral density from wrist radiographs, in a UK general radiography setting.
Methods
The study used a health economic model that compared the health outcomes and costs of screening with IBEX BH versus usual care for men and women aged 50 and older who had a forearm radiograph for any reason. The model incorporated data on fracture incidence, fracture risk reduction, mortality, quality of life, and fracture and treatment costs from published sources and Royal Cornwall Hospitals NHS Trust. Costs and health outcomes in terms of quality-adjusted life years (QALYs) were simulated over the remaining lifetime of patients. The analysis took the perspective of National Health Service (NHS) and Personal Social Services in the UK.
Results
The results showed that screening with IBEX BH was associated with a gain of 0.013 QALYs and a cost saving of £109 per patient compared with usual care, making it a dominant (cost-saving) strategy. Sensitivity analyses confirmed the robustness of the results under various assumptions. Widespread adoption of IBEX BH in the NHS was estimated to save 8,066 QALYs and £65,930,555 in healthcare costs over the lifetime of patients visiting hospitals for wrist radiographs each year.
Conclusions
IBEX BH could be a cost-effective tool for early identification and prevention of fragility fractures in the UK, addressing the current challenges of low provision and access to fracture risk assessment and treatment.
Observation of spherulitic covalent triazine frameworks grown from melts
Authors: Chen Zhen , Fang Tianhao , Xing Yifeng , Wu Huimin , Gao Duan , Xu Xiaomin , Zhang Zhenghua , Wang Huaizhen
Published: August 2024

As emerging porous crystalline polymers, covalent organic frameworks (COFs) present exclusively in form of polycrystalline powders, single crystals, and thin films. Here we report a spherulitic covalent triazine framework (CTF) grown from its monomeric melt, which exhibits a typical Maltese cross pattern of light extinction. A structural evolution from small-angle branched nanofibrils to a core-shell hemispherical geometry is real-time recorded by in situ microscopies and spectroscopies. Time-resolved imaging analysis on spherulitic growth unveils a nonclassical crystallization process, which involves a secondary nucleation–growth mechanism coupled with amorphous-to-crystalline transition and self-templating polymerization. Furthermore, fluorine doping into CTF enables acceleration of core-shell growth and self-templating reaction, yielding well-developed spherulites with the average size up to ~48 µm in diameter. Our findings demonstrate an unprecedented form of COF crystallites and provide insights into polymerization and crystallization processes under solvent-free conditions via in situ characterization.
Biocatalytic methane oxidation
Authors: Yeom Soo-Jin , Seo Min-Ju , Jeong Yeon-Ju , Le Thien-Kim , Kim Da-Mi , Sung Bong Hyun , Lee Seung Jae , Lee Eun Yeol , Yun Chul-Ho
Published: August 2024

The direct oxidation of methane to methanol using biocatalysts represents a groundbreaking advancement in effective natural gas utilization and methane valorization. The biological conversion of methane gas to methanol, which can serve as carbon feedstock, presents a significant economic opportunity. In nature, methane monooxygenases (MMOs), in both soluble and particulate forms, selectively oxidize methane to methanol. MMOs exhibit low activity, complexity, and are not readily tractable for recombinant expression in industrial microbial hosts. Achieving high volumetric productivities of methanol from methane requires functionally faster methane-converting enzymes, which has remained a major challenge in the field of methane oxidation. In this study, we report the discovery of the first cytochrome P450 from Caldimonas thermodepolymerans (CtCYP116B, i.e., CYP116B144), which is heterologously and highly expressed in Escherichia coli, and demonstrates the ability to directly convert methane to methanol. CtCYP116B exhibited the highest methane oxidizing activity (total turnover number of 606), surpassing other methane-converting enzymes. Furthermore, multi-enzyme cascade reactions using CtCYP116B, methanol dehydrogenase, and carboligases successfully produced C3−C4 chemicals from methane gas in vitro. The utilization of these functionally heterologously expressed CtCYP116B enzymes provide a powerful approach, serving as a key step in the construction of synthetic methanotrophs with significant biotechnological potential.
Ispinesib Mesylate-induced oxidative stress via miR-30e-5p/BCL2L11 axis in acute myocardial infarction: a comprehensive bioinformatics and experimental validation investigation
Authors: Ningxia Wu , Fei Li
Published: August 2024

Objective
Cardiovascular disorders constitute a substantial threat to global human health and safety. Of note, acute myocardial infarction (AMI), being a grave cardiovascular disorder, has garnered considerable attention owing to its elevated prevalence, mortality and broad demographic distribution. It is well established that hypoxia-induced apoptosis significantly contributes towards the onset and progression of AMI; however, several aspects regarding the biological indicators and molecular mechanisms of AMI remain elusive.
Method
This investigation utilized the Gene Expression Comprehensive (GEO) database to perform comprehensive analysis of pivotal genes employing techniques like differential analysis, Venn analysis, and weighted correlation network analysis (WGCNA). Subsequently, the correlation between the key genes and correlation factors was scrutinized, and the potential causal link between these factors and the outcome of AMI was probed via Mendelian randomization (MR). Additionally, real-time quantitative polymerase chain reaction (RT-qPCR) and lentivirus transfection experiments were executed, miRNA-mRNA networks were constructed utilizing miRBase databases, three-dimensional structures were predicted with the aid of RNAfold and Vfold3D databases, and drug sensitivity analysis was conducted using RNAactDrug databases.
Result
Following classification, WGCNA clustering, and Wien screening analysis, two distinctly expressed genes intimately linked to apoptosis - PTEN and BCL2L11 - were successfully identified. The outcomes of RT-qPCR and lentivirus infection experiments corroborated that the expression pattern of BCL2L11 conformed with our prior findings. Mendelian randomization analysis unveiled a robust causal relationship between BCL2L11 single nucleotide polymorphisms (SNPs) and AMI. Lastly, through miRNA-mRNA network and drug susceptibility analysis, it was discerned that the Ispinesib Mesylate, Bleomycin (50 uM)/miR-141-3p/BCL2L11 axis could potentially serve as efficacious therapeutic or preventive strategies against AMI.
Conclusion
In this study, we introduced the novel concepts of Ispinesib Mesylate and Bleomycin (50 uM)/miR-141-3p/BCL2L11 axis, offering a fresh perspective on the apoptotic mechanism in AMI.
A Bibliometric Review Leveraging the use of Computational Thinking for educational sustainability in STEM subjects: A Framework for Teaching and Learning in the 21st Century.
Authors: Dewa Alton
Published: August 2024

Computational Thinking (CT) has been recognised as an innovation framework to solve abstract problems to manageable tasks. In manufacturing industry, it plays a significant role to develop some working systems and application. Similarly, in teaching and learning, educators may apply this technique to unpack a rather challenging problem to solve into a more granularly structured concept that is easier to understand. This study uses a bibliometric method that build firm foundations on how school educators can integrate CT in their classroom instruction to advance some novel and meaningful ways of teaching. The data used was gathered from the Scopus database. Keywords such as “computational thinking,” “educational sustainability” and “teaching and learning” were used to extract papers from the database. Boolean operators such as ‘AND’ and ‘OR’ were used as wildcards to assist the searching of journals and conference proceedings in the related field. VOSviewer was used to prepare a co-authorship and co-occurrence map based on the bibliographic data gathered. The findings from the review of the literature indicates a huge knowledge gap in teaching using CT approach compared to a ‘common approach’ or ‘traditional’ way of teaching. Although CT approach is often used in computer science and related fields, it can also be used in other subjects, particularly, STEM subjects. The limitation of the study is that only one database, Scopus, was used to gather data. Despite the use of a single database, the findings open a novel knowledge gap that can be explored to enhance teaching and learning approach.
The CAP coherence between redistributive and environmental goals: do the allocation criteria for direct payments play a role?
Authors: Frascarelli Angelo , CIliberti Stefano , Bartolucci Paolo Emilio , Mastandrea Giada
Published: August 2024

The Common Agricultural Policy (CAP) has incorporated environmental sustainability in addition to traditional goals aimed at enhancing farmers’ incomes. However, such a policy intervention is not free from drawbacks and limitations. We focus on decoupled direct payments (DDP) investigating whether and how the choice of the criteria for their allocation across farmers can impact on CAP coherence and effectiveness, that is the ability to jointly achieve redistributive and environmental goals. Based on a Spearman correlation analysis performed on the FADN dataset including farms from 28 European countries in the period 2015-2017, the present paper sheds lights on the disputed role of land as criterion of allocation of DDP. Despite a high level of heterogeneity of farms characteristics across the EU, quantitative evidence reveals the existence of alternative criteria of allocation of these public aids which can robustly improve policy coherence and therefore CAP effectiveness in matching equity and sustainability.
Studying the Communicative Culture of Senior Preschoolers from the Position of the Theory of Mind
Authors:   Ulyanovsk State Pedagogical University named after I. N. Ulyanov, Khalimdarova Gyuzeliya R.
Published: August 2024

The article presents the experience of studying the communicative culture of senior preschoolers and its connection with the theory of mind. Modern researchers such as A.Yu. Rachugina (Ulanova), E. A. Sergienko, Ida Kurcz have established the relationship between communicative skills, communicative competence, informational success of communication of a senior preschooler and the development of the theory of mind. However, no work has been carried out that would allow to establish or refute the connection between the formation of the behavioral component of communicative culture and the development of the theory of mind in senior preschoolers. As a rule, visible manifestations of the behavioral component are reflected in the actions and actions of the child in relation to adults and peers. Its formation is confirmed by the ability to solve conflicts independently, comply with the rules, propose the goal of a common activity, plan its content, coordinate actions with others when solving common tasks, etc. Thus, the purpose of this research is to study the connection of the theory of mind with the development of the behavioral component of the communicative culture of senior preschoolers. The methods used in the study include the analysis of literary sources of domestic and foreign scientists, observation of children, testing, and the method of mathematical data processing. Within the framework of the study, the main content and semantic aspects of the concept of “communicative culture of a senior preschooler” are determined, approaches to the study of the phenomenon of the theory of mind are analyzed. The article describes in detail the methodology of diagnostics of the theory of mind of senior preschoolers, which has been carried out with the help of foreign methods of diagnostics of this ability adapted by us. As a part of the study, the behavioral component of the communicative culture has also been diagnosed, taking into account the multidimensional nature of the phenomenon under study. The results of the correlation analysis indicate the presence of significant links between such criteria of the behavioral component as the ability to constructive cooperation, manifestation of organizational skills and development of the theory of consciousness in preschoolers. The data obtained will expand the existing understanding of the mechanisms of formation of the communicative culture of senior preschoolers.
The Virtual Travel in Foreign Language Communicative Competence Developing of Pedagogical Direction Students
Authors:   Pskov State University, Baeva Irina V.
Published: August 2024

The issue of organizing virtual trips in foreign language classes at the university and other educational organizations arouses considerable interest among Russian and foreign authors. Undoubted relevance of virtual tours was acquired in today’s conditions of digitalization of the educational environment. The growing number of published scientific articles and manuals on the organization of distance travelling in English classes is the best example. The purpose of the study is to concretize methodically virtual travel as a technology in the development of student’s foreign language communicative competence. The main methods are scientific literature studying and referencing, products of students’ activities analysis, questionnaires and pedagogical experiment. The hypothesis proof is about effective foreign language communicative competence development pedagogical direction and language profile students in the conditions of virtual travel showed the results of student activity that were obtained during the experimental digital tours. The practical significance is expressed in the use of virtual travel platforms by students for self-improvement from the position of students and in professional future teachers’ development. Innovation lies in the application of the author’s pedagogical technology “verbal digital portfolio” and the saving the language product in the form of a video story about a visit in the section “My virtual travels”. Adaptive-and-integrative approach has been developed to implement the principles of visibility and communicative orientation that promotes digital adaptation and integration of knowledge from various fields, as virtual travel is impossible without cultural, historical, geographical or literary information. The prospects of the research are laid in virtual tours improvement and new forms of teaching foreign languages development, as well as individual competencies of students.
Using Lexical Approach in Teaching English to the Students of Mining Engineering Majors
Authors: Eremina Victoria M. ,   Transbaikal State University
Published: August 2024

Use of a lexical approach in teaching students of technical majors has become relevant and popular in recent years. To develop communication skills of a modern mining specialist and master professional English vocabulary, it is necessary to use the elements of the lexical approach in the course of studying the discipline “Foreign Language”. The relevance of this study is due to the need to study the possibilities of applying the lexical approach to the formation and development of a mining student’s lexical competence. Lexical competence is one of the components of linguistic competence and plays a leading role in the formation of the future engineer’s communicative skills. It can be considered as one of the strategically important competencies, since its formation influences the ability to use language depending on the communication situation. This study aims to examine the theory and practice of applying the lexical approach, to determine and identify its advantages, as well as the results of its use for the development of the future mining engineer’s lexical competence. The research methods we applied involved analysis, comparison, generalization of scientific literature on the use of the lexical approach, as well as empirical methods, including observation, questionnaires, review of experience, etc. The paper presents author’s recommendations and a set of training tasks and techniques aimed at mastering specialized vocabulary, allowing to apply the lexical approach in teaching a foreign language (English) to the students of mining engineering majors. The conclusion can also be drawn that further work is needed to draw up special exercises and teaching materials for the development of the lexical competence of future mining engineers.
Possibilities of Using the Project Approach at the University in the Study of Specialized Mathematical Disciplines
Authors: Kononenko Natalya V. ,   Transbaikal State University, Tokareva Julia S. , Desnenko Svetlana I. , Fedotova Alena D. ,   Transbaikal State University,   Transbaikal State University,   Transbaikal State University
Published: August 2024

The introduction of a project approach into the educational process in mathematics helps to develop students’ project thinking, which is so necessary for a high-demand university graduate, and prepares them to work in a modern innovative environment. This paper presents a study on the implementation of interdisciplinary project work as part of the development of specialized mathematical disciplines. Such work allows university students to form associative links between a mathematical model and real life situations that can serve as a starting point for decision-making. The project approach, aimed at integrating knowledge and skills in mathematics and economics has practical significance and usefulness in the study of specialized mathematical disciplines, because the use of interdisciplinary projects allows us to illustrate the fundamental mathematical content. The purpose of this study is to identify the possibilities of using the project approach in the process of studying specialized mathematical disciplines. The methodological basis of the research is project-based and practice-oriented approaches. Research methods: theoretical; empirical. The paper presents examples of projects proposed for the development of students of mathematical training areas of higher education institutions. The projects are presented in the context of sections of mathematics and contain a description of the relevant mathematical and economic apparatus. The toolkit is advisory in nature and can be selected depending on the studied mathematical discipline and the level of financial literacy of a particular student. The approach under consideration is a series of both students and university teachers, including the integration of mathematics and economics at the level of possible concepts, methods and approaches to solving problems in various branches of mathematics. As part of the study, a survey of university students was conducted, which was conducted in two stages. The results of the work can be used in the educational process of higher educational institutions.
Artistic Experimentation of Older Preschoolers: Approaches to the Study and Design of Pedagogical Support
Authors: Verbenets Anna M. ,   A. I. Herzen Russian State Pedagogical University
Published: August 2024

The problem of mastering experimentation in visual activity by senior preschoolers is relevant in the light of clarifying the directions of artistic development in the context of the Federal Educational Program of Preschool Education, insufficient factual study of the phenomenon of artistic experimentation, empiricism and “didacticism” in determining the methods of its accompaniment. The purpose of the study is to justify approaches to designing the development of artistic experimentation in children 6–7 years old based on the study of its features and originality. The article attempts to specify the concept in the light of the ideas of modern art education (development of combinatorial and artistic abilities); the idea of the similarity of the three directions of experimentation (“research”: the search for the possibilities of pictorial materials; “combinatorial”: the study of expressiveness, “creative”: solving the creative problem of creating an expressive image), which constitutes elements of novelty. Empirical study has obtained two groups of results. “Research” results: on the basis of stating data (when using observation, diagnostic tasks), the features and originality of artistic experimentation of children 6–7 years old (“indicative” and “procedural” nature, connection with the development of artistic abilities, cognitive skills; activation by visual means); dominance of personal manifestations over activity and productive ones; different “strategies” – children’s actions in experimentation. “Design” results: pedagogical conditions are formulated and an example of experimentation support technology is given. An invariant part of the work on the sequential enrichment of childhood experience is presented within the framework of 3 areas of experimentation; a variable part focused on the achievements and deficits of children (through targeted support techniques). Examples of the focus of educational situations are given; sequence algorithm in mastering different drawing techniques, providing interiorize examples of the focus of educational situations; sequence algorithm in mastering different drawing techniques, providing interiorization of experience; options for supporting children are set based on typical difficulties and successes.
PLACE AND IDENTITY: REPRESENTATIONS OF NORTH AND SOUTH VIETNAM IN MAI THẢO’S WRITINGS BETWEEN 1954 AND 1975
Authors: Nguyễn Đình Minh Khuê ,   Faculty of Literature, University of Social Sciences and Humanities, Vietnam National University Ho Chi Minh City, Bến Nghé Ward, District 1, Ho Chi Minh City, Vietnam
Published: August 2024

After the Geneva Accords in 1954, nearly one million people left North Vietnam for the South. They are primarily called Bắc di cư. There have been numerous studies on these North Vietnamese refugees, the majority of which are centred around examining them as anti-communists and devout Christians and elucidating the governmental policies and the socio-economic effects related to their southward migration. Nevertheless, limited scholarly attention has been paid to their contested emotional experiences and representations of their homeland in North Vietnam and the place of their arrival in the South. These under-researched aspects possibly denote their complex awareness of themselves while living in the South between 1954 and 1975, if we take into account the theory of the sense of place, which generally stresses the interconnection between place and identity. This article examines how North and South Vietnam are represented by Mai Thảo—a prominent Northern émigré writer in the Republic of Vietnam—in his works published between 1954 and 1975. The aim of this study is to indicate Mai Thảo’s complicated psychological experiences of the place of his origin and the place he took refuge after his migration in 1954 and, more generally, his consciousness and representation of his identity. I argue that in his works of the late 1950s, North and South Vietnam are mostly represented as politicised places from the vision of a proactively anti-communist Mai Thảo, whilst his depictions of North Vietnam as a lost paradise associated with beautiful recollections and a dystopian South during the 1960s and early 1970s highlight his self-consciousness as a diasporic subject.
Субанестетические дозы кетамина как вспомогательное средство для контроля послеоперационной боли у родильниц с низким болевым порогом: рандомизированное контролируемое исследование
Authors: Шиндяпина Н. В. , Маршалов Дмитрий Васильевич , Шифман Е. М. , Кулигин А. В.
Published: August 2024

INTRODUCTION: One in five women experiences high-intensity pain after a cesarean section. OBJECTIVE: Evaluation of the effectiveness of low-dose ketamine in the prevention of high-intensity pain in women with a low pain threshold after cesarean section. MATERIALS AND METHODS: A randomized controlled trial (RCT) was conducted on 90 women who underwent elective cesarean section (CS) under spinal anesthesia. Women were stratified into two categories: normal and low pain threshold. Within each subgroup, the patients were randomized into three groups: intraoperative intravenous administration of ketamine at a dose of 0.25 mg/kg; 0.5 mg/kg, and control group. The time to first request for analgesia and total tramadol dose during the first postoperative day were recorded. The frequency of adverse reactions was analyzed. RESULTS: The median and interquartile range (IQR) for mean pain intensity in the first day, pain on movement, and pain at rest 24 hours after CS were significantly higher in the control group compared to the ketamine groups (p < 0.001). Time to first requirement of analgesia increased in the ketamine 0.5 mg/kg group 190.0 [175.0–195.0] minutes compared with the control group 130.0 [130.0–140.0] minutes with p < 0.001. Tramadol consumption on the first day was significantly lower in the ketamine groups compared with the control groups (p < 0.001). Between-group statistically significant differences in the studied pain indicators in the ketamine groups (0.5 and 0.25 mg/kg) were not observed in either patients with a normal or low pain threshold (p > 0.005). Adverse effects (distorted reality and visual impairment) at the minimum dosage of 0.25 mg/kg were observed exclusively in patients with a normal pain threshold. CONCLUSIONS: For patients with an initially low pain threshold, the use of ketamine at a dose of 0.25 mg/kg has the best efficacy and safety profile.
Анестезиологическая летальность: основные причины и факторы риска. Обзор литературы
Authors: Лебединский К. М. , Беликов В. Л. , Гузовский Егор Игоревич
Published: August 2024

INTRODUCTION: The lethal outcome associated with anesthesia or surgery is an indicator of both the safety of patients in the perioperative period and the level of healthcare. OBJECTIVE: We analyzed the causes and risk factors of anesthetic mortality according to the world literature in order to justify the necessity of confidential enquiry on perioperative critical events in the Russian Federation. MATERIALS AND METHODS: We analyzed the references published from 2000 to 2023 in the databases PubMed, Google Scholar, MEDLINE and eLibrary (for Russian authors). RESULTS: Of the 5,190 results, only 97 papers turned out to be relevant. After careful study, 29 full-text publications were selected as met all the selection criteria and were included into the analysis. In most of the reported observations, there is a global decrease in anesthesia-related mortality. The main dominant causes remains exactly the same (respiratory and hemodynamic disorders) with conventional risk factors (ASA grades 3–5, after-hours operations, etc.). Unfortunately, we were unable to collect data on the situation in the Russian Federation, since such studies have not yet been conducted here. CONCLUSIONS: Despite the decrease in anesthesia-related mortality, the main causes remain constant: respiratory disorders and violation of instructions for the use of drugs or their incorrect use. In the last decade, in research, the authors have been paying attention to risk factors for the occurrence of critical incidents, the main of which is, for example, operations at night. Since traditional causes of anesthesia-related death may constitute the basis of accusation, in order to effectively study the safety of anesthesia, develop protocols and recommendations, it seems to be necessary to create a regularly conducted confidential enquiry in Russia, similar to NCEPOD in the UK.
Cabrerite, NiMg2(AsO4)2·8H2O, a new old mineral – the ordered intermediate between annabergite and hörnesite
Authors: Kampf Anthony R. , Adams Paul M. , Ma Chi
Published: August 2024

Cabrerite (IMA2023-123), NiMg2(AsO4)2·8H2O, is a newly approved mineral species from the Nickel mine, Cottonwood Canyon, Table Mountain district, Churchill County, Nevada, U.S.A. that was originally described in 1863 from Sierra Cabrera, Almería, Andalusia, Spain. At the Nickel mine, cabrerite occurs in divergent groups of green blades up to 1 mm long. Blades are elongated and striated parallel to [001], flattened on {010}, and exhibit the forms {010}, {110}, and {20-1}. The mineral is transparent with vitreous luster and white streak. The Mohs hardness is ~2½. The mineral has moderately sectile tenacity, irregular and stepped fracture, and three cleavages: perfect on {010}, fair on {100} and poor on {-102}. The measured density is 2.93(2) g·cm-3. The mineral dissolves slowly in RT H2O. The mineral is optically biaxial (+), α = 1.609(2), β = 1.633(2), γ= 1.667(2) (white light); 2Vmeas = 82(2)°; slight r < v dispersion; orientation X = b, Z ^ c = 37° in obtuse β; nonpleochroic. Electron microprobe analysis provided the empirical formula (Mg1.46Ni1.55)∑3.01(As1.00O4)2·8H2O. Cabrerite is monoclinic, C2/m, a = 10.2054(11), b = 13.3772(13), c = 4.7382(4) Å, β = 105.057(7)°, V = 624.66(11) Å3, and Z = 2. The mineral has a vivianite-type structure (R1 = 0.0353 for 668 I > 2σI reflections) in which MlO2(H2O)4 octahedra and M22O6(H2O)4 edge-sharing octahedral dimers are linked together via TO4 tetrahedra (where T = P or As) and hydrogen bonds to form layers parallel to {010}; successive layers are linked by hydrogen bonds only. Cabrerite is the ordered intermediate between hörnesite and annabergite, with Ni dominant at M1, Mg dominant at M2, and T = As.
Training in cardiothoracic transplantation in the 21st century: Inspired apprenticeships with a scientific trend
Authors: Khoshbin Espeed
Published: August 2024

[No abstract, showing first paragraph]

Sir Peter Medawar was a 20th century British biologist and Nobel prize winner. He was a pioneer in the field of tissue rejection and transplantation. He inspired many, including Christian Barnard and Sir Magdi Yacoub, surgeons who need no introduction to the reader (Figure 1).
Beyond troponins: Emerging diagnostic significance of novel markers in NSTEMI
Authors: Varshney Amit , Ram Vidya , Kumar Pankaj
Published: August 2024

Objective: This study aims to comprehensively analyze a multiple-marker panel consisting of 55 morphofunctional and biochemical markers in 123 patients diagnosed with non-ST-segment elevation myocardial infarction (NSTEMI). The goal of this study was to identify novel pathogenetic landmarks and diagnostic predictors associated with NSTEMI.
Methods: The study includes 123 patients diagnosed with NSTEMI based on ESC Guidelines criteria. Clinical characteristics, morphofunctional markers, and serum levels of 53 biochemical markers related to inflammation, oxidative stress, endothelial dysfunction, cellular injury, hemostasis, and myocardial remodeling were assessed. A control group of 47 healthy individuals was included for comparison.
Results: NSTEMI patients exhibited an activated inflammatory status, oxidative stress, and endothelial dysfunction. Notable increases in inflammation markers, alterations in adipokines, and changes in oxidative stress markers were observed. Endothelial dysfunction markers indicated vascular remodeling and dysfunction. Cellular injury markers, including cMyBP-C, suggested myocardial necrotic injury. Hemostasis markers showed impaired anticoagulant systems, and ECM remodeling markers indicated increased matrix metalloproteinases.
Conclusion: The multiple-marker panel provides insights into novel pathogenetic entities associated with NSTEMI. Markers such as MPO, MMP-8, E-selectin, PhA2, Ang 2, FE, MF, and cMyBP-C demonstrate potential diagnostic and prognostic value. This comprehensive analysis enhances our understanding of NSTEMI pathogenesis and offers potential targets for therapeutic interventions.
Citalopram & escitalopram: Mechanisms of cardiotoxicity, toxicology predisposition and risks of use in geriatric & hemodialysis populations
Authors: Farhat Hadi , Nassif Lea , Tlaiss Yehya , Gutlapalli Sai Dheeraj , Abdulaal Razan
Published: August 2024

The selective serotonin reuptake inhibitors (SSRIs) citalopram and escitalopram are extensively prescribed for various psychopathies.  Despite their reputation for safety compared to older antidepressants, concerns have arisen regarding their cardiotoxic potential, notably in prolonging the QTc interval. In this comprehensive review, we investigate the intricate mechanisms of cardiotoxicity induction by citalopram/escitalopram, with a special focus on their interactions with ion channels like Kv11.1, Nav1.5, and Cav1.2 which may contribute to QTc-prolongation, increasing the risk of life-threatening arrhythmias such as Torsades de Pointes (TdP). Moreover, we explore the predisposing factors to their associated cardiotoxicity along with an investigation of the QRS/QTc ratio as a potential biomarker for identifying patients at risk of ventricular arrhythmias, taking into consideration the impact of genetic variations and drug interactions, especially those involving the liver CYP2C19 metabolism. Our review extends to the geriatric population's use of citalopram and escitalopram, emphasizing the significance of assessing a patient's medical history and cumulative drug use to evaluate their susceptibility to cardiac adverse events. Finally, we scrutinize the compound relationship between QTc-prolongation, proton pump inhibitors (PPIs) and serum-to-dialysate potassium gradients in influencing the proarrhythmic potential of citalopram/escitalopram in hemodialysis patients.
Response of benthic diatom assemblages to environmental heterogeneity in an urban river: implications for environmental monitoring
Authors: Xing Bo , Huang Jinjing , Sun Songhua , Xiang Qiaoming , Yao Miaojun , Li Jingjing , Dai Weisheng , Zhang He , Wang Binliang
Published: August 2024

Benthic diatom assemblages can sensitively respond to aquatic environmental changes. However, it is still ambiguous whether benthic diatom assemblages can well indicate the environmental status in an urban river with highly heterogeneous habitats. This study investigated the environmental heterogeneity of an urban river and explored the response of benthic diatom assemblages to environmental changes. First, the urban river showed significant spatio-temporal heterogeneity in both physical and chemical characteristics. Higher concentrations of total nitrogen and CODMn indicated eutrophic and organic pollution conditions in the river. In addition, benthic diatom assemblages also implied the habitat heterogeneity of the urban river. Dominant diatoms, including Nitzschia palea, Melosira varians, Cyclotella meneghiniana, and Achnanthidium minutissimum, are pollution-tolerant species, further confirming the eutrophic and organic status. Then, the interaction between environmental heterogeneity and benthic diatom assemblages was analyzed by redundancy analysis and Mantel tests. Results suggested that environmental variables, such as conductivity, total nitrogen, total phosphorus, and chlorophyll a, significantly affected the composition of benthic diatom assemblages in the urban river. These findings demonstrated that environmental heterogeneity shapes the benthic diatom assemblages of the urban river, and benthic diatoms can be good indicators of environmental status for urban river monitoring and assessment.
Piscicultura marina del róbalo (Centropomus undecimalis)
Authors: Gaitán Saeko , Gaitán Saeko , Villamizar Natalia , Villamizar Natalia , Prieto Martha , Jesús Pedro , Miguel Wilfrido , de María , Ángel José , Pérez Oskarly , Enrique Cesar , Correa Jesús , Altamar Jairo
Published: August 2024

La piscicultura marina del róbalo en Colombia enfrenta desafíos nutricionales, pero se han logrado avances significativos en la alimentación de larvas y en la formulación de alimentos balanceados. En este contexto, el libro aborda integralmente los retos y avances en este campo, además de destacar la importancia de la nutrición en el cultivo del róbalo, donde hay logros en la alimentación de las larvas, lo que contribuye a mejorar la viabilidad de la producción. Asimismo, se resalta la relevancia de la formulación de alimentos balanceados para garantizar un crecimiento óptimo de los peces. El cultivo del róbalo se presenta como una alternativa promisoria para contrarrestar la sobreexplotación de la especie en Colombia, y se han identificado áreas óptimas en el Caribe colombiano para el desarrollo de la piscicultura marina de róbalo. La identificación de áreas propicias para el cultivo es fundamental, pues de estas depende el crecimiento sostenible de esta actividad en el país.
A teoria dos rizomas e a ação rizomática na cena da matança dos cavalos
Authors: Soares Anna Claudia , Ricardo Gioppo Fábio
Published: August 2024

O conceito de rizoma desenvolvido por Deleuze e Guattari é apresentado como um modelo de pensamento e organização que desafia estruturas hierárquicas e dicotomias tradicionais, privilegiando conexões fluidas e movimento constante. Desta forma, o problema de pesquisa deste artigo é: Como o conceito de rizoma de Deleuze e Guattari pode ser aplicado em uma análise literária? Tendo como objetivo apresentar a aplicação do conceito de rizoma investigando as complexidades das relações entre o bem e o mal na cena da matança dos cavalos na obra Grande Sertão: veredas de Guimarães Rosa. Utilizando como metodologia de pesquisa a análise literária. A cena da matança de cavalos exemplifica como o sofrimento causado pelo mal afeta não apenas os jagunços rivais, mas também os próprios perpetradores. A transformação do mal em bem, ainda que temporária, ressoa com as ideias de Benedictus de Spinoza sobre o bem como algo útil. Portanto, ao realizarmos a análise literária dessa cena apresentamos a relevância do conceito de rizoma para a reflexão ética e moral.
From Drama to Transformation as a Person and an Emergency Unit Professional in the Pandemic: A Grounded Theory Approach
Authors: Zanferrari Natália Martins , de Cássia Altino Rita , Bocchi Silvia Cristina Mangini
Published: August 2024

Background

Pandemic flows have proven increasingly challenging, signaling the need for more effective global policies that benefit healthcare worker safety.

Objectives

To understand the health staff's interactional experience in an emergency unit with the COVID-19 pandemic and to develop a theoretical model representative of this experience.

Methods

A qualitative research with theoretical saturation through analysis of the 15th non-directive interview, according to Grounded Theory, was developed with physicians, nurses, and nursing technicians in an emergency unit who experienced the pandemic's beginning.

Results

The experience unfolded into subprocesses: Considering oneself, at the beginning of the pandemic, as the leading actor of a drama (A); Looking for strategies to cope with the pandemic (B); Transforming as professional and person (C). From dramatic leading role to professional and personal improvement of healthcare staff in emergency services during COVID-19.

Conclusion

The model indicated a staff waking up to occupational risks with pathogens in the interface with symbols of the devastating and dramatic concreteness of the SARS-CoV-2 virus and insufficient informational, material, human, and psychosocial resources, encouraging them to use standard precautions even after the pandemic.
Material, Design and Fabrication of Soft Robots
Authors: Qu Juntian , Li Zhenkun , Fan Qigao , Cui Hongchao , Liu Yueyue
Published: August 2024

Elastomer, hydrogel, shape memory polymers, electro-active polymers, and liquid
metal possess some advantages and special performance, especially in soft robots. The
flexibility of soft robots, for example, also derives from biologically inspired structural designs
and numerous additive manufacturing methods.
This chapter provides a detailed overview of the above five types of materials. The concepts,
composition, classification, synthesis principles and properties of these materials are discussed
in details. We also summarize and classify the design of release structures for soft robots,
including crawling soft robots on land and underwater soft-bodied robots. We analysis and
summarize the design and manufacturing methods of soft robots through the existing relevant
research results, and finally elaborate on the problems facing future development, in the hope
that it can help and guide the direction of research related to soft robots. 
Pengaruh Perubahan Tata Guna Lahan Terhadap Debit Banjir Dan Laju Erosi Di DAS Jatiroto
Authors: Muhammad Taufik Nurcahyo Taufik , Very Dermawan  , Sumiadi
Published: August 2024

Daerah Aliran Sungai (DAS) Jatiroto merupakan daerah yang aliran yang sering terjadi bencana ketika musim hujan. Pada tahun 2018 – 2022 setiap tahunnya DAS Jatiroto mengalami bencana banjir dan keruntuhan tanggul sungai. Pada beberapa lokasi di DAS jatiroto juga mengalami tanah longsor ketika musim penghujan. Hal tersebut dikarenakan kondisi topografi DAS jatiroto dan perubahan tata guna lahan jatiroto. Tujuan dari penelitian ini adalah mengetahui besarnya erosi yang menyebabkan banjir dan perubahan tata guna lahan yang terjadi di DAS Jatiroto. Sehingga dapat dijadikan sebagai analisis lebih lanjut terkait pengendalian banjir akibat sedimentasi yang disebabkan oleh erosi di DAS Jatiroto dan pengendalian erosi dengan cara konservasi lahan reboisasi. Hasil dari simulasi erosi dan debit banjir menggunakan metode MUSLE dengan HEC-HMS 4.10 berdasarkan tata guna lahan tahun 2017 didapatkan debit banjir kala ulang 2­th sebesar 312,6 m3/dt dengan rerata laju erosi sebesar 12,05 ton/ha/tahun, kala ulang 5­th sebesar 475,1 m3/dt dengan rerata laju erosi sebesar 20,00 ton/ha/tahun, kala ulang 10­th sebesar 599,7 m3/dt dengan rerata laju erosi sebesar 26,4 ton/ha/tahun.
Studi Perencanaan Unit Bangunan Instalasi Pengelolaan dan Distribusi Utama Air Bersih di Desa Tegalombo Kecamatan Tegalombo Kabupaten Pacitan
Authors: Krisna Nata Kusuma  , Rini Wahyu Sayekti  , Moh. Sholichin
Published: August 2024

Air bersih merupakan suatu kebutuhan yang sangat penting bagi makhluk hidup. Pada musim kemarau merupakan salah satu kendala yang membuat langkanya persediaan air bersih, contohnya di Desa Tegalombo Kabupaten Pacitan dengan jumlah penduduk 3695 jiwa pada tahun 2021 yang belum terlayani oleh PDAM sehingga ketersediaan air bersih belum stabil kuatitas dan kualitasnya di musim kemarau . Untuk itu perlu dilakukan studi perencanaan pengelolaan unit instalasi air bersih untuk menambah persediaan air pada musim kemarau. Pada studi ini sebagai sumber utama untuk memenuhi kebutuhan air memanfaatkan air dari Sungai Grindulu dengan rata-rata debit sebesar 490,85 m3/detik. Untuk perencanaan akan diporyeksikan selama 6 tahun agar Desa Tegalombo mendapatkan kuantitas dan kualitas air yang stabil.
Analisa Keruntuhan Bendungan Kedung Brubus di Kabupaten Madiun Provinsi Jawa Timur Dengan Menggunakan Program Zhong Xing HY21
Authors: Rizal Affandi  , Pitojo Tri Juwojo  , Runi Asmaranto
Published: August 2024

Bendungan Kedung Brubus yang berlokasi di Desa Bulu, Kecamatan Pilangkenceng, Kab. Madiun, Jawa Timur, memiliki kapasitas 2,025 juta m3 (per 2014) yang bertujuan untuk memberikan suplai air irigasi di kabupaten tersebut.  Karena kapasitasnya yang besar, potensi bahaya yang dihadapinya juga fatal dan dapat menyebabkan kerugian material di wilayah permukiman sekitarnya. Oleh karena itu, penelitian ini ditujukan untuk analisa dan simulasi keruntuhan bendungan Kedung Brubus menggunakan program ZhongXing HY21 dengan mengacu dalam dua kondisi. Simulasi pada waduk dalam kondisi normal yaitu piping dan kondisi ketika terjadi hujan dengan intensitas paling tinggi yang menyebabkan debit rancangan PMF (Probable Maximum Flood). Simulasi keruntuhan karena debit PMF ini diakibatkan overtopping dan piping. Berdasarkan hasil simulasi menggunakan software ZhongXing HY21, ditemukan bahwa debit banjir rancangan PMF mencapai 642,729 m³/det dan luasan banjir mencapai 31,56 km², dengan kedalaman banjir maksimum mencapai 6,01 m. Akibat keruntuhan Bendungan Kedung Brubus, sebanyak 43 desa yang berada pada hilir bendungan terdampak dengan jumlah penduduk yang terkena risiko mencapai 27.931 jiwa. Dampak ini mengakibatkan konsekuensi serius bagi masyarakat dan lingkungan yang berada di wilayah terdampak.
Studi Perencanaan Jaringan Air Bersih di Dusun Batur, Desa Pelem, Kecamatan Bungkal, Kabupaten Ponorogo
Authors: Siswoko Bintang , Runi Asmaranto  , Emma Yuliani
Published: August 2024

Makhluk hidup tidak dapat bertahan hidup tanpa air, dan saat ini belum ada cairan yang dapat menggantikan peran air, sehingga air dapat dikatakan sebagai sumber kehidupan. Sebagai upaya untuk memenuhi kebutuhan air bersih, maka Pemerintah Desa Pelem, Kecamatan Bungkal, Kabupaten Ponorogo akan mendistribusikan air bersih kepada masyarakat Dusun Batur, Desa Pelem. Tujuan studi ini untuk mengetahui kebutuhan air Dusun Batur sampai tahun 2032, kapasitas reservoir, perencanaan jaringan air bersih dengan aplikasi software WaterCAD V8i. Metode yang digunakan pada studi ini yaitu dilakukan dengan mengumpulkan data jumlah penduduk, peta kontur, dan debit sumur bor air yang berada di Dusun Batur, Desa Pelem, Kecamatan Bungkal, Kabupaten Ponorogo. Hasil rata-rata kebutuhan air pada jam puncak di Dusun Batur yaitu sebesar 1,424 liter/detik. Hasil running jaringan menggunakan software WaterCAD V8i, bahwa sistem perpipaan berjalan dengan baik dan optimal. Pipa yang digunakan pada studi ini yaitu berjenis PVC dengan diameter pipa 1 inci dan 2 inci. Serta volume bangunan tandon yang didapatkan yaitu 24 m3. Hasil simulasi kondisi hidrolis dari segi tekanan, kecepatan, headloss gradient tersebut telah memenuhi standar yang telah ditetapkan. Anggaran biaya total yang digunakan yaitu sebesar Rp 867.179.047,00.