bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors in Pancreatic Adenocarcinoma: the Interrelation with Familial History and Predictive Role on Survival
Authors: Petrusel Livia , Bilibou Maria , Drug Vasile , Leucuta Daniel Corneliu , Seicean Radu , Cainap Calin , Seicean Andrada
Published: September 2020

Background and Aims: Pancreatic cancer is associated with poor survival and quality of life. In Romania the prognostic influence of known risk factors for pancreatic adenocarcinoma, such as age, smoking, chronic pancreatitis, diabetes mellitus, and obesity is little known. Their importance in developing cancer in families with a history of adenocarcinoma is less studied. This study aims to assess the risk factors in pancreatic ductal adenocarcinoma, in familial pancreatic adenocarcinoma, in neuroendocrine tumors and to evaluate their predictive role on survival.

Methods: We performed a prospective bicentric study of patients with pancreatic tumors detected in transabdominal imaging; we assessed the risk factors and their possible association with survival.

Results: 312 pancreatic cancer patients (279 with pancreatic ductal adenocarcinoma and 24 patients with neuroendocrine tumors, and nine patients with other malignant types) and 312 controls were included. The median body mass index was significantly higher in patients with neuroendocrine tumors. Positive family history for pancreatic cancer was found in 4% of patients with pancreatic cancer. The risk for familial pancreatic carcinoma was associated with the presence of new-onset diabetes (OR: 4.64, p=0.018). The multivariate logistic analysis suggested that advanced age (OR: 1.67), smoking (OR: 1.67), low body mass index (OR: 12.07), and diabetes (OR: 3.91) were risk factors for pancreatic cancer. The overall survival analysis after adjustment for age and tumor stage showed only advanced tumoral stage (HR=1.6, p=0.003) and metastasis as independent predicting factors (HR=1.67, p<0.001).

Conclusion: Our study suggests that diabetes, smoking, underweight, and age over 60 years are risk factors for pancreatic cancer. Patients with a family history of pancreatic cancer, especially those with new-onset diabetes, should be followed carefully and considered for screening. Only an advanced tumor stage was associated with poor overall survival for patients with pancreatic ductal adenocarcinoma.
Reopening Endoscopy after the COVID-19 Outbreak: Indications from a High Incidence Scenario
Authors: Elli Luca , Tontini Gian Eugenio , Scaramella Lucia , Cantù Paolo , Topa Matilde , Dell'Osso Bernardo , Muscatello Antonio , Gori Andrea , Neumann Helmut , Vecchi Maurizio , Penagini Roberto
Published: September 2020

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Collision Tumor Composed of an Inflammatory Myofibroblastic Tumor and Adenocarcinoma of the Colon: a Rare Entity
Authors: Cornacchia Chiara , Rutigliani Mariangela , Belli Fiorenza , Romano Nicola , Serventi Alberto , Fiocca Roberto , Filauro Marco
Published: September 2020

This report presents the case of an 83-year old man with a collision tumor consisting of an inflammatory myofibroblastic tumor (IMT) and adenocarcinoma of the left colon. As the clinical and radiologic features of IMT are non-specific, only the accurate histopathological examination from the left hemicolectomy specimen was diagnostic. Although the prognosis of a colorectal IMT seemed more favorable than in other sites, four months after surgery the patient developed a tumor relapse. Therefore, malignant behavior of IMT could not be totally excluded. Recent studies have demonstrated that a chromosomal rearrangement involving 2p23, the site of the anaplastic lymphoma kinase (ALK) gene, is present in a subset of these tumors. In our patient, tumor cells did not present ALK-1 perinuclear positivity and it could have indicated a less favorable prognosis. The collision of these different entities is extremely rare and this is the first case reported in literature. Further cases of collision tumors with clinical information including their treatment and prognosis are needed.
Epidemiologic Association between Inflammatory Bowel Diseases and Type 1 Diabetes Mellitus: a Meta-Analysis
Authors: Lu Shuang , Gong Jian , Tan Yuyong , Liu Deliang
Published: September 2020

Background and Aims: Patients with inflammatory bowel diseases (IBD) are at high risk of developing several autoimmune diseases. However, the epidemiological connection between IBD and type 1 diabetes mellitus (T1DM) remains controversial. This meta-analysis aimed to determine the association between the two diseases.

Methods: A literature search was performed using Medline, Embase, and Central databases from inception to December 31, 2019. Studies evaluating the prevalence of T1DM in patients with IBD and controls were included. Statistical analysis was performed with a random effects model using the generic inverse variance method.

Results: After the literature research, five cross-sectional studies and one case-control study met the inclusion criteria. A total of 45,103 participants with Crohn’s disease (CD) and 76,046 with ulcerative colitis (UC) were included. The pooled odds ratios (ORs) of T1DM were 1.16 (confidence interval [95% CI]: 0.87–1.55) in patients with CD and 1.20 (95% CI: 0.90–1.59) in patients with UC compared with the control groups. Significant heterogeneity was observed (CD: I 2 =70% and UC: I 2 =80%) in the complete analysis. Subgroup analysis stratified by study region was performed. Recalculated results indicated a positive association between CD and TD1M in Northern Europe with an OR of 1.65 (95% CI: 1.43–1.90; I 2 =0%). Patients with UC in Israel were at a higher risk of developing T1DM with an OR of 1.70 (95% CI: 1.38–2.09; I 2 =0%).

Conclusion: The complete meta-analysis suggests no association between IBD and T1DM. However, the subgroup analysis indicated that patients with CD or UC from specific regions may be at a higher risk of developing T1DM than those without IBD.
First record of Piper robustipedunculum Yunck. (Piperaceae) in the state of Pernambuco, Brazil
Authors: de Queiroz George Azevedo , Guimarães Elsie Franklin , Sakuragui Cassia Monica
Published: September 2020

Piper L. is the largest genus of Piperaceae with about 2,000 species worldwide. Brazil is home to 466 of these species. They are found mainly in the Atlantic and Amazonian forests. This is the first record of Piper robustipedunculum Yunck in the state of Pernambuco, a species which was previously considered restricted to the state of Bahia. We consulted the herbaria CEN, HAMAB, HEPH, IBGE, IPA, MAC, R, RB, RFFP, UB, UFP, UFMT, UPCB and the virtual speciesLink and Reflora databases. Additionally, we elaborated a description and a distribution map to the species.
The economic security issues of periodicals by the example of women’s magazines
Authors: Kirsanov Konstantin , Alimova Natalia
Published: September 2020

The authors consider the economic security issues of the modern periodical press by the example of women’s «glossy» publications.
The article briefly describes the history of dissemination of women’s periodical in the world and in Russia. A comparative analysis of circulation and prices for advertising was carried out by the example of three magazines Vogue, Elle and Marie Claire.

The authors note that the early XXI century marked the beginning of a protracted crisis for publishers of women’ gloss. First off, this is due to the development of Internet and digital technologies.
Taking the above mentioned into considerations, we can conclude about the high level threats of economic safety for the modern periodicals, in particular, for the women’s magazines. First of all, this is drop in incomes from sales of circulations and advertise. In addition, a dollar volatility leads to an increase in the cost of magazine edition. The share of income received from the magazine sites still amounts to a miserable interests. The deliberate overstatement of circulations leads to the publishers’ reputational damage. All this results in the fact that the problems of raising level of economic security for the modern gloss enter into in the foreground.
Ubiquitous Diagnostics SARS-CoV-2 LAMP-LF v1
Authors: Kumar Vishnu , Subramanian Ramesan Venkata , Kumar Joshi Suraj , Toley Bhushan
Published: September 2020

The LAMP primer sequence in Ubiq-COVILAMP-LF protocol targets the S gene in the novel coronavirus (2019-nCoV). The protocol consists of enzymes Warmstart BST 2.0 polymerase for isothermal amplification and Warmstart reverse transcriptase for reverse transcription. Lyophilisation of the reaction mix is done to increase the input sample volume, and enhance end-user experience. A LAMP assay for an internal control gene, human RNase P is also included to ensure that the extracted RNA is intact and of high quality.
A General Protocol for Pilot-Testing the Screening Stage of a Systematic Review (Manual) v1
Authors: Whaley Paul , Garside Ruth , F Eales Jacqualyn
Published: September 2020

Studies of potential relevance to the objectives of a systematic reviews, as found by the search strategy, should be screened in duplicate for their eligibility. This screening process should be piloted. This protocol provides a step-by-step formula for piloting the screening process of a systematic review. The formula is also applicable to the conduct of systematic evidence maps. There are generally three reasons for piloting the screening process of a systematic review: Are the eligibility criteria expressed clearly enough? Are the screeners on the review team interpreting the criteria consistently? Are there papers which should be included in the review but had not been anticipated as being relevant? This protocol presents a process for answering each of these questions in the affirmative and preparing to ensure that the screening step of the systematic review is a success, i.e. it does not result in exclusion of evidence which is relevant to the research question.
Rank-Order of Body Shapes Reveals Internal Hierarchy of Body Image
Authors: Naor-Ziv Revital , King Rose , Glicksohn Joseph
Published: September 2020

How do individuals rank body shapes? Does this relate to the body part one is most dissatisfied with? Our study investigates whether one can generalize regarding how women represent the body. Three BMI-calibrated images from the Photographic Figure Rating Scale, representative of thin (BMI = 14.72), medium (BMI = 20.33), and large (BMI = 29.26) shapes, were divided into torso, legs and arms, and saved as individual images on a black background. Of 27 possible composite images, 8 were chosen based on a Torso (thin vs. large) × Leg (thin/large vs. medium) × Arm (thin vs. large) design.  Our 44 female participants ordered these from thinnest to largest. This was first according to torso, then leg, and finally arm:  41 individuals agreed on the thinnest image (thin torso, thin legs, thin arms), followed by a second image (thin torso, thin legs, large arms, n = 26; or thin torso, medium legs, thin arms, n = 10). One participant differed markedly in her choice of the first image (large torso, medium legs, thin arms). Interestingly, she scored 10 on the EDI-2 scale of Bulimic Tendencies, revealing high risk for bulimia, suggesting that our task might be useful for studying eating disorders. Our juxtaposition of two analytic procedures—partial order scalogram analysis (POSAC) and cluster analysis—enables one to uncover such outliers in a data set. Importantly, the 2D POSAC space clearly reveals the hierarchical structure of the body image.
Profiling a Spectrum of Mental Job Demands and their Linkages to Employee Outcomes
Authors: Mauno Saija , Minkkinen Jaana
Published: September 2020

Working life is becoming more mentally demanding and intense due to technological acceleration. The present study explored employees’ experiences of different mental job demands (MJDs) and their outcomes (job burnout, job performance, and meaning of work). We focused on intra- and inter-individual variations and possible harmful combinations of MJDs, which we explored via latent profile analysis (LPA). To identify harmful combinations of MJDs, we also investigated how the profiles of MJDs related to the outcomes of interest. The study was based on a diverse sample of Finnish employees (n = 4,583). LPA showed that both intra-individual and inter-individual variation characterized MJDs as we identified five latent profiles of MJDs. The most harmful profile, which predicted the most negative outcomes (particularly job burnout), was characterized by employees’ scoring high on all MJDs. A profile characterized by low learning demands and moderate level of other MJDs was also a harmful combination in terms of outcomes. In contrast, a profile characterized by moderate level of learning demands and low level of other MJDs did not relate to negative outcomes. Altogether, the findings suggest that different MJDs may co-occur implying risks to employee well-being and performance. However, MJDs simultaneously form a complex spectrum that may differ within and between individuals.
SUNDANESE DIALECT IN SINAR RESMI TRADITIONAL VILLAGE IN CISOLOK DISTRICT, SUKABUMI REGENCY: PHONOLOGICAL PERSPECTIVE
Authors: Thamrin Husni , Isnendes Retty
Published: September 2020

The main purpose of this study is to find out the similarities and differences in the form of speaking dialect intonation of Sirna Resmi tradisional society of Sukabumi Regency which is spoken by parents and young people. This study is conducted qualitatively with identification and classification in the form of Sundanese intonation of conversation dialect. Participants are two people with the age level of young (36 years old) and parents (69 years old). Data is collected by interview and record notes. Analysis of conversational dialect data is based on phonological theory of intonance referred to Katamba (1996). The first data is found with a number of intonations of conversational dialects from young people (36 years old) totaling 30 conversation sentences. From the data found three types of categories, namely; First intonation of downdrift tones is found in 2 types. Second, the tone of the downstep is found in 10 types. Third, the tone upstep is found in 18 types. In the second data, it was found that conversational dialect sentences of parents (69 years) amounted to 30 sentences of parents as elders in the Sinar Resmi village indigenous people. From the data that found three types of categories, namely; 1) Intonation of downdrift tones found 10 types. 2) Intonation of downstep tone found 11 types. 3) Intonation of upstep tones found 9 types.
SYMBOLS OF THE DEATHLY HALLOWS IN J.K. ROWLING’S “HARRY POTTER AND THE DEATHLY HALLOWS”
Authors: Nasta Mardiyanah , Hasriani G. Hasriani G. , Asriati Asriati
Published: September 2020

This research aimed to describe what the Deathly Hallows symbolized in J.K. Rowling’s “Harry Potter and the Deathly Hallows”. This was a qualitative content analysis with hermeneutic approach. The primary data was from the novel of Harry Potter and the Deathly Hallows. The results of this research were the Deathly Hallows symbolized the thirst of the greatest power which could make the owner immortal, but for Harry Potter they symbolized a test, which tested his mission to defeat Voldemort. The Hallows themselves consisted of three objects which were the Elder Wand, the Resurrection Stone, and the Invisibility Cloak. Each of the Hallows also symbolized different things. The Elder Wand symbolized a wizard’s desire for power, the Resurrection Stone symbolized deep longing towards the loved one who had died, and the Invisibility Cloak symbolized protection.
PENGEMBANGAN MODUL SINTAKSIS BERMODEL DISCOVERY LEARNING UNTUK MAHASISWA PENDIDIKAN BAHASA INDONESIA
Authors: Rohmah Faizatur
Published: September 2020

This study aims to (1) describe the process of syntax module development with the discovery learning model, and (2) describe the quality of a syntax module with the discovery learning models on a syntax material. This development model uses the ADDIE model (analysis, design, development, implementation, evaluation). The results of this study are (1) the process of the syntax module development designed through five stages, namely analysis, design, development, application, and evaluation; (2) the quality of the syntax module tested through the criteria of validity, practicality, and effectiveness. The validity data results are obtained from the expert validator assessment is of category very valid. The effectiveness data of student activities is of category good, the activity of the lecturers is of category very good, and the completeness of student learning is complete. The practicality data obtained from the assessment of the implementation of RPS is of category very good, student responses, and lecturer responses are of category positive.
THE STRUCTURE OF THE STATE ECONOMIC POLICY OF UKRAINE IMPLEMENTATION
Authors: Kornilova J.
Published: September 2020

The article is devoted to the analysis of the structure of the state economic policy of Ukraine implementation. The research uses a wide range of general and special legal methods and techniques of scientific research, in particular: analysis and synthesis, induction and deduction; comparative legal, structural-functional, formal-dogmatic methods. As a result of the study, the author substantiates the scientific position that determining the structure of economic policy of Ukraine and its elements, ensuring their coordinated interaction is a priority in the effective functioning of this area of public policy of Ukraine. Unfortunately, the current model of Ukraine's state economic policy in Ukraine is not able to ensure its effectiveness. As a model, it is proposed to take the one developed by German scientists, which provides for the consistent interaction of such elements of the structure of public policy as a strategy, a plan, the implementation of the plan and a report on the implementation of the plan. This model of implementation of economic policy of Ukraine should be the basis for public administration of the economy of Ukraine. Legal support of public administration by economic policy of Ukraine needs to be streamlined and strengthened. According to the author, this goal can be achieved through the adoption, first of all, of the National Strategy for Economic Development of Ukraine, which will become a strategic document. It should specify the purpose, goals, strategic objectives and principles of state economic policy of Ukraine. Based on it, plans for the implementation of this National Strategy should be developed as tactical documents. They should identify step-by-step measures to implement this strategy. Keywords: economy, state policy, administrative law, a structure, legislation.
Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi
Authors: ABUDAYYAK Mahmoud , KANBOLAT Şeyda , BATUR Şeyma , ERGENE Reyyan , ALİYAZICIOĞLU Rezzan
Published: September 2020

Jurinea brevicaulis is a perennial herbaceous plant belonging to the Asteraceae family. J. brevicaulis is an endemic genus and grows Erzincan and Gümüşhane provinces in Turkey. Jurinea species are known to have anticancer, antibacterial, antifungal and antioxidant effects. In this article, it is aimed to evaluate the antioxidant capacity and cytotoxic effects of J. brevicaulis. Results indicate that, TPC values were between 41.7 - 537.5 GAE µg g-1, FRAP values were between 109.52 - 1076.2 µM Trolox equivalent g-1, CUPRAC values were between 231.4 - 3083.3 µM Trolox equivalent g-1, IC50 values in DPPH determination were between 0.0102 - 3.4174 mg mL-1. The extracts caused cell death in a concentration-dependent manner in, IC50 values were calculated to be between 3.67-10.2 µg mL-1. In conclusion, the cytotoxic effects in cancerous cells and the high antioxidant capacity indicates that J. brevicaulis could be an important herb in developing new drugs.
Suicidism: A new theoretical framework to conceptualize suicide from an anti-oppressive perspective
Authors: Baril Alexandre
Published: September 2020

Anchored in queer and crip perspectives, this essay proposes the neologism "suicidism" as a new theoretical framework to conceptualize the oppressive system in which suicidal people experience forms of injustice and violence. The thesis proposed here is that suicidal people suffer both individually and collectively from suicidist violence, an oppression that remains unproblematized in all current interpretations of suicide, including those taken up by anti-oppressive scholars and activists. I pursue three interrelated objectives: 1) interrogate dominant ideas and perspectives on suicidality; 2) make visible and denounce the power relations between suicidal and non-suicidal people; 3) enrich intersectional analyses by naming and problematizing an oppression that has been neglected. In sum, this essay proposes to analyze suicidality by asking the following epistemological questions: What and who is missing from current conceptualizations of suicide? What can we learn from these absences? How might new understandings of suicide, from queer and crip perspectives, help anti-oppressive scholars and activists avoid reproducing forms of oppression toward suicidal people? This essay is divided into two parts. The first part reviews some of the predominant models of suicide to illustrate how they all arrive at the same conclusion—that suicide is never an option—and how this results in a silencing of suicidal subjects. In so doing, I also demonstrate how suicidism is intertwined in forms of ableism/sanism. I conclude this first part by mobilizing the notion of epistemic injustice to theorize both the testimonial and hermeneutical injustices experienced by suicidal subjects. In the second part, I explore additional interpretations of suicide that contrast with the dominant "negative" conceptualizations that seek to prevent it in all circumstances. I demonstrate how even "positive" perspectives of suicidality (e.g. the libertarian position) are founded in forms of ableism/sanism, and that even though they may critique the marginalization of suicidal subjects, they don't conceptualize their oppression as systemic, nor address it from an anti-oppressive perspective. Critiquing the "positive" conceptualizations of suicide allows me to delineate an alternative conceptualization of suicide rooted in queer and crip perspectives. Mobilizing a queer perspective to study suicide doesn't mean offering only analyses that take queer theories as a starting point or queer communities as the objects of the study. The intention is rather to queer suicide in a more holistic sense, that is, by applying queering and cripping methods, theories, epistemologies and prevention strategies to the topic of suicidality. Based on a harm-reduction and a non-coercive suicide approach, I suggest that assisted suicide should be a possibility for suicidal people, a position that relies on an ethics of living and a responsibility toward suicidal people.
An observational study on clinical and bacteriological profile of new-borns with early onset sepsis
Authors: Tharu Mobin George , Santhakumar Rati , Manoj V. C.
Published: September 2020

Background: Neonatal sepsis related mortality is preventable with timely recognition, rational antimicrobial therapy and aggressive supportive care. The objective of this study was to study the maternal and neonatal risk factors in new-borns with early onset sepsis and to ascertain commonest pathogen responsible.Methods: This study was done in the neonatal intensive care unit tertiary care hospital, Thrissur. Data collected after clinical examination and from the records of new-borns diagnosed with early onset sepsis were analyzed. All neonates suspected to have sepsis had a septic screen to corroborate the diagnosis. Blood culture was performed in all cases of suspected sepsis prior to starting antibiotics. The risk factors for sepsis, both maternal and neonatal were analysed. Their clinical features and bacteriological profile were studied. Data analysis was done using their mean±standard deviation (SD), percentage analysis, chi-square test or fischer’s test.Results: Fifty newborns with diagnosed early onset sepsis (EOS) were studied. Results suggest that maternal screening is prudent, interventions like vaginal examination were causative of sepsis than meconium stained liquor or prolonged rupture of membranes. A coincidental finding suggests that sepsis is more common in males and term babies. Blood culture showed predominant pathogen to be Klebsiella.Conclusions: Among the maternal factors, increased frequency of vaginal examination was most prevalent in the study group. Prematurity and asphyxia were not strong pre-runners for sepsis. EOS cases presenting with respiratory distress were 50%. Fever and tachycardia were the next common clinical features. The cases yielded blood culture positive were 20% and Klebsiella pneumonia (40%) was the commonest organism isolated.
Healing the chronic wounds in diabetes using old drugs
Authors: Hassan Khaled M. , Hamdi Abdullah A. , Alhamad Suhail A. , Alanzi Reem Q. , Aleid Yousef A. , Aldarwish Abdullah S. , Almuntashiri Abdullah H. , Almudawi Khalid Y. , Alkhalifah Abdullah A. , Banjabi Alaa F. , Al-matar Sarah H. , Al-ayash Turki S. , Basrawi Duaa J. , Aleidan Mashael I. , Alnami Muataz I. , Aljumaiah Mohammed A.
Published: September 2020

People with uncontrolled diabetes may develop poor circulation. As circulation slows down, blood moves more slowly, which makes it more difficult for the body to deliver nutrients to wounds. As a result, the injuries heal slowly, or may not heal at all. Due to the effects of diabetes on the nerves and blood vessels, diabetic patients might also experience other complications. These include heart disease, kidney disease, and eye problems. Hence, the need for therapeutic drugs is a must. In this review we analyze some drugs that have been used in diabetes wound healing including antiglycemic agents like dipeptidylpeptidase-4 (DPP4) inhibitors and metformin, statins and phenytoin. These drugs showed satisfying results giving the diabetes patients a glimmer of hop regarding their wound healing.
Ear, nose and throat emergencies: an experience in rural area
Authors: Sumbria Deepshikha , Hamid Waqar Ul , Yousuf Aamir , Ahmad Rauf
Published: September 2020

Background: Ear, nose and throat (ENT) emergencies are very common throughout the world. Early diagnosis and prompt treatment in the hands of expert will result in reduction of morbidity, mortality and referrals.

Methods: This retrospective study was conducted on 352 patients reporting in out-patient department (OPD) and emergency of District Hospital Ramban from June 2016 to May 2017. Demographic data as well as diagnosis were studied. The type of anaesthesia and type of procedure and outcome of emergency case were recorded. Patients with terminal cancer care admitted were excluded from the study.  

Results: A total of 352 patients, 204 males and 148 females were included in present study. The commonest emergency was foreign body (69.03%), trauma (11.9%), epistaxis (9.6%), and abscess (6.8%). Procedures done were foreign body removal, fracture reductions, soft tissue injury repair, incision and drainage, packing and cauterisation.

Conclusions: Foreign body is the most common cause of ENT emergency and it is a preventable accident. Education of parents and public at large will go a long way in reducing these preventable mishaps in children. Timely management of emergencies in the hand of experts reduces the mortality and complication rate.
Prevalence and spectrum of pediatric dermatoses in school children: comparing hospital and school in rural Bangalore
Authors: K. A. Rajeshwari , M. Geetha , B. Kiran
Published: September 2020

Background: Pediatric dermatoses are emerging distinct entities. The exact prevalence and pattern of dermatoses is not well known in India. This novel study attempts to simultaneously assess the prevalence and distribution of skin dermatoses in hospital and community among children of age 5-16 years in rural Bangalore, India.

Methods: A cross sectional prospective descriptive study of one week duration in July 2019 was conducted in east point hospital and Government school in rural Bangalore in the vicinity.

Results: The study had a total of 119 children, 72 from the hospital and 47 from the school with prevalence of dermatoses being 33.8% and 70% respectively (p<0.00001). Primary school children were most commonly affected. Non-infectious dermatoses were most common, more so in school with eczematous lesions predominating. Bacterial infectious dermatoses were found more frequently in hospital children, while parasitic infestations were encountered commonly in school. 

Conclusions: Pediatric dermatosis seems to be widely prevalent in India. Children visiting hospitals constitute only the tip of the iceberg present in the community.
Is the Structure of the Strategic Approach to Coping Scale Cross-Culturally Stable? Evidence Based on a Scoping Literature Review
Authors: Bartczuk Rafał P. , Chwaszcz Joanna , Hobfoll Stevan E. , Niewiadomska Iwona , Gałkowska-Bachanek Maria
Published: September 2020

The Strategic Approach to Coping Scale (SACS) is a measure based on the Multiaxial Model of Coping. The original version of the scale consists of nine subscales, which form three second-order factors. An up-to-date review of SACS cultural adaptations was provided in order to examine the evidence for the cultural stability of SACS first- and second-level structures. The review demonstrated that among the SACS first-level factors some are more culturally stable and some are more sensitive to cultural context. The second-order structure of the SACS is more interculturally stable, especially the active–passive and social factors have a robust empirical justification.
Developmental Participation: The Necessity of Cultural Perspectives in Developmental Psychology
Authors: Siekiera Natalia , Białek Arkadiusz
Published: September 2020

This main aim of this paper is to present some theoretical considerations about the need for a cultural approach in modern developmental psychology. Starting with a critique of the over-universalisation of developmental research in American psychology, the authors present a paradigm of a relational-developmental system, using the concept of embodiment and a cultural approach in psychological research, in which the principal object of analysis is person-in-action as a culturally inclusive alternative for developmental psychology. This approach will be exemplified by research on development through guided participation and the role of shame in moral and social development in Confucian culture.
The Relationship with the Father and the Emotional Functioning of Women in Adulthood
Authors: Szudy Katarzyna D. , Puchalska-Wasyl Małgorzata M.
Published: September 2020

Some studies, conducted also in Poland, show that the influence of fathers’ behavior on their daughters extends beyond childhood. For example, fathers’ parental attitudes assessed retrospectively (such as demands, inconsistency, lack of acceptance, and lack of autonomy) are associated with different mental disorders experienced by their adult daughters. The aim of the present study was to determine whether the retrospective evaluation of the relationship with the father explains the emotional functioning of women in early and middle adulthood. The participants were 180 women aged between 20 and 53. We used the Parental Bonding Instrument, the Questionnaire of Retrospective Assessment of Parental Attitudes, and the Trait Personality Inventory. Our findings support a link between the relationship with the father and the emotional functioning of women. In future it would be advisable to broaden the scope of the study by including groups of daughters in adolescence and in late adulthood or women with various problems.
Modern approaches to the choice of antimicrobial agents for pelvic inflammatory diseases: the role of innovative microbiological methods
Authors: О. А. Бурка  , Т. М. Тутченко  , Н. Ю. Педаченко  , О. М. Кудлай
Published: September 2020

Pelvic inflammatory diseases (PID) is comprehensive term that includes infectious-inflammatory lesions of the endometrium, fallopian tubes and ovaries. PID is one of the main causes of treatment of reproductive aged women by gynecologists, and the cause of impaired reproductive function, chronic pelvic pain syndrome and ectopic pregnancy in the absence of treatment.This article provides an overview of current clinical guidelines for diagnosis and general treatment approaches of PID. A detailed analysis of modern scientific researches dedicated to the change of the PID’s pathogens structure and the peculiarities of their clinical presentation today. This analysis showed that despite the leading role of sexually transmitted infections, opportunistic flora is of great importance in the pathogenesis of this pathology. Features of the PID’s clinical course include an increase in the recurrence frequency. These features are associated with the growing worldwide phenomenon of antibiotic resistance.Data from the European Antimicrobial Resistance Surveillance Network report at the European Center for Disease Control “Antibiotic Resistance Surveillance 2017” on the resistance prevalence of clinically relevant pathogenic bacteria to the most commonly used antimicrobials. Nonspecific bacterial pathogens of PID in the European region show a fairly high rate of antibiotic resistance. At the same time, the experience of many countries demonstrates the effectiveness of the strategy of antimicrobial stewardship strategy, one of the main principles of which is microbiological research whenever possible when prescribing antibacterial therapy. Thus regardless of whether representative of the opportunistic flora is a direct cause of a severe PID course or secondary due to previous sexually transmitted diseases, its identification and antibiotic susceptibility testing is critical for the effective treatment of PID (especially severe forms) given the prevalence of antibiotic resistance.
Differentiated approaches to prevention of perinatal complications in pregnant women with miscarriage in early gestation
Authors: О. В. Кравченко
Published: September 2020

Purpose of the study was to develop differentiated approaches to prevention of perinatal complications in pregnant women with miscarriage in the early stages of gestation.Materials and methods. We examined 52 patients who had been diagnosed risk of abortion at an early pregnancy, both with and without bleeding. Criteria for exclusion from the study were multiple pregnancy, pregnancy as a result of assisted reproductive technologies, pregnancy in women with severe extragenital pathology, genital anomalies, and pregnancy with diagnosed fetal abnormalities. All pregnant women underwent a comprehensive clinical and laboratory examination. At the end of the first trimester during transvaginal ultrasound with a special three-dimensional VOCAL program we calculated the chorionic volume and evaluated its vascular system.Results of the study. Chorionic volume decrease by 10–15%, and a vascularization index by 20–25% at 12–13 weeks in 50% patients after treatment for early miscarriage (group I). Volume of chorion was reduced by 16–25%, and the vascularization index by 26–35% in 23.1% women (group II). Only in 26.9% pregnant women after treatment the volume of chorion and indicators of blood flow were within the physiological range (control group). Pregnant women with chorionic hypoplasia (group I and II) continued hormonal therapy in the II and III trimesters with the aim of effectively securing the second wave of cytotrophoblast invasion and adequate growth of uterine placental blood flow. They were prescribed micronized progesterone, venotonic drug Normoven, metabolite drug Artichol and Magnicum. Non-hormonal therapy was performed in cycles of 15–18 weeks, 25–28 weeks, and 32–35 weeks. Results of the study showed that the incidence of gestational period complications in pregnant women with chorionic hypoplasia and impaired vascularization in early gestation (group I and II) was higher than in the control group, but significantly lower than in literature.Conclusions. Determination of chorionic volume and evaluation of its vascular system at the end of the first trimester of gestation can serve as a criterion for patient selection for the group of perinatal complications risk. Chorionic hypoplasia and impaired vascularization in pregnant women with early miscarriage are indicative of further drug therapy in the II and III trimesters. The complex of medical drugs (micronized progesterone, Normoven, Artichol, Magnicum) has proven itself as an effective method for prevention of perinatal complications in pregnant women with miscarriage in the first trimester.
Associative relations between hypofunction of the thyroid gland of various origins and iron deficiency anemia
Authors: О. А. Гончарова
Published: September 2020

Background. Anemia is one of the thyroid deficiency manifestations, more often iron deficiency. The combination of hypothyroidism and anemia is an additional factor complicating the life quality of patients and requiring of adequate preventive measures.Purpose of the study was to establish the peculiarities of iron deficiency anemia in women with hypothyroidism that arose against the background of autoimmune thyroiditis (AIT) or after surgical treatment of nodular nontoxic goiter (NNG).Materials and methods. Thyroid status was assessed in 40 women with anemia on the background of hypothyroidism due to AIT (n = 28) and after surgery for NNG (n = 12) by the level of thyroid stimulating hormone and bound tetraiodothyronine, antibodies to thyroperoxidase. Anemia and its severity were determined by the blood hemoglobin level, number of red blood cells and color indicator.Study results. Level of thyroid stimulating hormone was increased in women of both groups on the background of levothyroxine in an individually selected dose, and it was significantly higher in group with postoperative hypothyroidism. Level of antibodies to thyroid peroxidase testified to the pronounced activity of antithyroid immunity in the group with AIT. Hemoglobin level in both groups ranged from 92 to 116 g/l, which according to WHO criteria corresponded to mild anemia. It was significantly lower than with postoperative hypothyroidism against the background of AIT, despite the best compensation for hypothyroidism. Color index in both groups was reduced, that is typical for hypochromic anemia, which includes iron deficiency anemia.Conclusions. Effectiveness of levothyroxine treatment in individually selected doses in women with a combination of hypothyroidism and anemic syndrome is higher at autoimmune thyroid pathology than after surgery for NNG. Active autoimmune process in women with hypothyroidism on the background of AIT is associated with more manifest anemia than in women with postoperative hypothyroidism as a result of NNG.
Role of the hormonal system “Vitamin D/Vitamin D receptors” in the formation of some pregnancy complications
Authors: Manasova G. S. , Andrievsky A. G. , Didenkul N. V. , Shpak I. V. , Turchyn M. I. , Kuzmin N. V.
Published: September 2020

Introduction. The hormonal system “vitamin D/vitamin D receptors” (VD/VDR) is involved in the regulation of numerous physiological processes. VD lack or deficiency is associated with a number of different diseases, including pregnancy complications.Purpose of the study: to determine VD status and its effect on the course of the gestational process in women from the southern region of Ukraine.Materials and methods. 459 women were examined, 318 (69.3%) of them were the main group and 141 (30.7%) were the comparison group.In addition to standard general clinical examinations, ELISA on a COBAS Integra 400 Plus analyzer (Roche Diagnostics, Switzerland) the VD level was determined in the blood.Results and discussion. 49.9% of the pregnant women in the main group had insufficient VD level (25.45 ± 4.63 ng/ml), in 19.4% it corresponded to a deficit (15.28 ± 4.78 ng/ml). VD concentration in the comparison group was 43.38 ± 9.67 ng/ml (p <0.01). Significantly more frequent pregnancy complications in the main group were threatening abortion (45.6% VS 9.9%; F = 0.00001; p <0.01), preeclampsia (13.5% VS 2.8%; F = 0.0093; p <0, 05), placental dysfunction (32% VS 7%; F = 0.00001; p <0.01), vaginal dysbiosis (64.4% VS 18.4%; F = 0.00001; p <0.01), pregnant anemia (43.7% VS 20.6%; F = 0.0008; p <0.01) and signs of inflammation of the amniotic membranes (38.3% VS 13.4%). Syndrome of intrauterine growth retardation diagnosed in 9% women in the main group; in the comparison group none case was noted.Conclusion. 70% of pregnant women in Odesa region have a lack or deficiency of VD. Pregnancy course is characterized by a significantly greater frequency of preeclampsia (4.8 times more often), placental dysfunction (4.5 times), threat of miscarriage (4.6 times more often), intrauterine infection (2.8 times more often), gestational anemia (2.5 times more). It seems promising to conduct further research on the possibility of preventing complications of the gestational process by correcting VD status.
Resolution of the I International forum of experts in menopause
Authors: Ф. А. Гафурова  , М. Гегечкори  , А. Л. Громова  , А. А. Давлетбаева  , М. Джанелидзе  , Т. А. Ермоленко  , Е. В. Занько  , Б. Ж. Иманкулова  , Е. Н. Кириллова  , Д. И. Кристесашвили  , Н. Марсагишвили  , Г. Т. Мырзабекова  , Л. Надареишвили  , Н. Н. Педаченко  , И. Г. Персоян  , В. И. Пирогова  , Л. Пхаладзе  , А. Э. Самигуллина  , Т. Ф. Татарчук  , О. А. Теслова  , У. М. Уразова  , С. А. Эм
Published: September 2020

On November 8–9, 2019 in Tbilisi (Georgia) the I International Forum of Menopause Experts initiated by the Association of Gynecologists-Endocrinologists of Ukraine was held. Expert working group included leading specialists in the field of obstetrics and gynecology in Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Uzbekistan and Ukraine. Experts presented data of their countries on the status of menopause management, experience in solving problems of this period of life.During medical counseling women should pay special attention to the timely start of therapy, explaining the benefits and risks of menopausal hormone therapy (MHT), identifying age-dependent risks and ways to overcome them. MHT is the most effective and pathogenetically substantiated method for the correction of menopausal disorders today. The goal of MHT is to partially compensate for the deficiency of sex hormones using minimally optimal doses that can improve the general condition of women and ensure the prevention of late metabolic disorders and osteoporosis.Individualization of MHT depends on the patient's age and menopausal status. For each stage of woman's reproductive aging according to the STRAW+10 a balanced decision is required on the choice of the regimen and dosage of the combined MHT with therapeutically effective low-dosage forms. It is recommended to start MHT mainly in perimenopause or in early postmenopause, but with menopause duration no more than 10 years. It is necessary to evaluate the thickness of the endometrium using transvaginal sonography before therapy.In perimenopause it is preferable to start MHT in a combined cyclic regimen with a lower dose of estrogen. In postmenopausal women it is preferable to start with a lower dose of estrogen and use a continuous combined dosage regimen of estrogen and gestagen. It is proposed a continuous assessment of the fractures risks to effectively prevent the osteoporosis in women in the postmenopausal period.An annual basic examination is necessary throughout the entire period of MHT use: measurement of weight, waist circumference and blood pressure level, gynecological examination, cytological examination of a cervical smear according to Papanicolaou, ultrasound of the pelvic organs with determination of the endometrium thickness and structure, mammography.
Research of systemic immunity and hemostasis in women with pathological processes of the epithelium of the genitals with atypia of cells of unclear genesis in women with infertility
Authors: В. В. Камінський  , О. Я. Бондарук  , І. О. Гак
Published: September 2020

Purpose of the study: to study the systemic immunity and hemostasis in women with infertility and pathological processes of glandular epithelium of genitals with atypical glandular cells not otherwise specified.Materials and methods. The study included 173 women with infertility and pathological processes of glandular epithelium of genitals with atypical glandular cells not otherwise specified (main group). The comparison group consisted of 100 women with infertility and without pathological processes of cervical epithelium. All patients underwent studies of the immune systems (population of lymphocytes, circulating immune complexes) and hemostasis (screening coagulation tests, number and aggregation function of platelets).Results. Analysis of the immune system revealed certain changes in the main group, more pronounced in women with endometrial pathology - inhibition of the cell link (evidenced by a decrease in absolute and relative CD3+ T cells value, absolute number of CD4+, CD16 and phagocytic number) against the background of humoral immunity activation (increase in the CD22+ level, circulating immune complexes, IgG and IgA). The study of the vascular-platelet hemostasis showed a decrease of platelets against the background of a tendency to an increase in platelet anisocytosis and an increase in platelet counts in women with endometrial pathology. An analysis of platelet aggregation function revealed a significant increase in platelet aggregation to adenosine diphosphate, adrenaline and collagen in patients with endometrial pathology, also a tendency to hypercoagulation.Conclusions. In women with infertility and pathological processes of glandular epithelium of genitals with atypical glandular cells there is suppression of the cellular immune system against the background of humoral immunity hyperactivation. Activation of the vascular–platelet hemostasis and a tendency to hypercoagulative state were revealed.
A mortal case of coronavirus disease in a pregnant diabetic woman. Clinical case
Authors: Uzel K. , Lakhno I. V.
Published: September 2020

Pregnant women are very susceptible to coronavirus infection. Gestational diabetes mellitus is severe comorbidity and a serious risk factor for lethal outcomes. We report a mortal case of coronavirus disease (COVID-19) associated with bilateral pneumonia and systemic inflammatory response syndrome in a pregnant woman with gestational diabetes mellitus.Patient was admitted to the hospital at 31 weeks of gestation with COVID-19 bilateral pneumonia. Anti-inflammatory, antiviral, antibacterial and immunomodulatory treatment was started. She received per os favipiravir 200 mg, azithromycin 500 mg, enfluvir 75 mg, plaquenil 200 mg, and ceftriaxone 1 g intravenously, piperacillin 4.5 g intravenously, methylprednisolone 40 mg intramuscular, enoxaparin 0.6 subcutaneously. The doses of insulin were changed. But maternal status became worse in several hours. Oxygen saturation dropped to 80%. Patient was intubated and connected to the artificial lung ventilator. The cesarean was performed. The preterm born baby with early neonatal sepsis diseased the next day. The treatment could not counteract an inflammatory storm. Despite intensive resuscitation, the woman diseased.The fatal case of COVID-19 was associated with coexisted gestational diabetes mellitus and late admission to the hospital. The COVID-19 patients with gestational diabetes mellitus are at higher risk of severe pneumonia, systemic inflammatory response and carbohydrate metabolism decompensation. Oxidative stress caused by bilateral pneumonia initiated the chain of tissue injury-related reactions. The fat tissue is an additional source of free radicals and proinflammatory cytokines. Progression of the proinflammatory scenario enhanced multiple organ failure. We have found signs of acute pulmonary, hepatic, and renal insufficiency. The unresponsiveness to treatment contributed to systemic inflammatory response and maternal deterioration.Further investigations are necessary to improve outcomes in COVID-19 during pregnancy.