bluuebunny/crossref_metadata_2025 huggingface dataset:
Bias Correction Method of High-Resolution Satellite-Based Precipitation Product for Peninsular Malaysia
Authors: Iqbal Zafar , Shahid Shamsuddin , Ahmed Kamal , Wang Xiaojun , Ismail Tarmizi , Gabriel Hamza Farooq
Published: December 2021

Satellite-based precipitation (SBP) is emerging as a reliable source for high-resolution rainfall estimates over the globe. However, uncertainty in SBP is still significant, limiting their use without evaluation and often without bias correction. The bias correction of SBP remained a challenge for atmospheric scientists. In this study, the performance of six SBPs, namely, SM2RAIN-ASCAT, IMERG, GsMap, CHIRPS, PERSIANN-CDS and PERSIANN-CSS in replicating observed daily rainfall at 364 stations over Peninsular Malaysia was evaluated. The bias of the most suitable SBP was corrected using a novel machine learning (ML)-based bias-correction method. The proposed bias-correction method consists of an ML classifier to correct the bias in estimating rainfall occurrence and an ML regression model to correct the amount of rainfall during rainfall events. The performance of different widely used ML algorithms for classification and regression were evaluated to select the suitable algorithms. IMERG showed better performance, showing a higher correlation coefficient (R2) of 0.57 and Kling-Gupta Efficiency (KGE) of 0.5 compared to the other products. The performance of random forest (RF) was better than the k-nearest neighbourhood (KNN) for both classification and regression. RF classified the rainfall events with a skill score of 0.38 and estimated the rainfall amount of a rainfall event with the modified Index of Agreement (md) of 0.56. Comparison of IMERG and bias-corrected IMERG (BIMERG) revealed an average reduction in RMSE by 55% in simulating observed rainfall. The proposed bias correction method performed much better when compared with the conventional bias correction methods such as linear scaling and quantile regression. The BIMERG could reliably replicate the spatial distribution of heavy rainfall events, indicating its potential for hydro-climatic studies like flood and drought monitoring in the study area.
Cephalexin Degradation Initiated by OH Radicals: Theoretical Prediction of the Mechanisms and the Toxicity of Byproducts
Authors: Masmoudi R. , Khettaf S. , Soltani A. , Dibi A. , Messaadia L. , BENAMIRA Messaoud
Published: December 2021

In this work, density functional theory is used to study the local reactivity of cephalexin (CLX) to radical attack and explain the mechanism of the reaction between CLX and hydroxyl radical attack leading to degradation byproducts. The reaction between •OH and CLX is supposed to lead to either an addition of a hydroxyl radical or an abstraction of a hydrogen. The results showed that the affinity of cephalexin for addition reactions increases as it passes from the gas to the aqueous phase and decreases as it passes from the neutral to the ionized form. Thermodynamic data confirmed that OH addition radicals (Radd) are thermodynamically favored over H abstraction radicals (Rabs). The ecotoxicity assessments of CLX and its byproducts are estimated from the acute toxicities toward green algae, Daphnia and fish. The formation of byproducts is safe for aquatic organisms, and only one byproduct is harmful to Daphnia.
Toosendanin Inhibits Colorectal Cancer Cell Growth Through the Hedgehog Pathway by Targeting SHH
Authors: Zhang Meng , Tao Zhongyi , Gao Lijuan , Chen Fengyang , Ye Yiping , Xu Shifang , Huang Wenkang , Li Xiaoyu
Published: December 2021

Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide. It is complex and often fatal and is associated with a high disease-related mortality. The Hedgehog (Hh) signalling pathway plays indispensable roles in CRC. Many studies have proven that Shh is overexpressed in cancer stem cells (CSCs) and shown that SHH overexpression is positively correlated with CRC tumorigenesis. The development of new drugs to kill CRC cells through the Hh pathway is urgently needed. Toosendanin (TSN), a natural triterpenoid saponin extracted from the bark or fruit of Melia toosendan Sieb. et Zucc., has been proven to inhibit various tumours. Here, we demonstrated that TSN inhibited the CRC cell growth through the Hh signalling pathway by targeting SHH. TSN has promising potential as an antitumour agent for CRC treatment.
CENPF Upregulation is Associated with Immunosuppressive Status and Predicts Poor Clinical Outcomes in Lung Adenocarcinoma Validated by Qrt- PCR
Authors: xu zhiyun , Wang Shi , Ren Zhijian , Gao Xiang , Xu Lin , Ren Binhui , Zhang Shuai
Published: December 2021

Background: CENPF was differentially expressed in various cancers. However, the relationship between CENPF and immune infiltrates in lung adenocarcinoma was previously unknown.Methods: We implemented a comprehensive analysis of expression of CENPF in the GEO and TCGA databases. CENPF was evaluated for its prognostic value combining clinical samples from the GEPIA2 and TCGA databases. The Metascape together with WebGestalt databases were used for enrichment analysis of genesets that were most postively associated with CENPF. We retrieved the score for immune cell infiltration in TCGA data and examined the correlation between CENPF expression and the infiltration of immune cell by R software.Results: The outcomes exhibited that up-regulated CENPF mRNA expression was evidently related to poor PFS, DSS and OS in patients with lung adenocarcinoma. Moreover, high expression of CENPF was markedly related to genes associated with immune checkpoint. Further analysis showed that T cell CD4+ Th2 infiltration increased in lung adenocarcinoma samples with high CENPF expression.Conclusions: Our study indicated that CENPF led to T cell CD4+ Th2 infiltration through oncogenic activity and may be employed as a biomarker for the prediction of prognosis in lung adenocarcinoma.
Lungworms (Metastrongylus Spp.) Demonstrated in Domestic Pigs with Respiratory Disease - What was the True Relevance of that?
Authors: Wallgren Per , Pettersson Emelie
Published: December 2021

BackgroundAn outdoor pig herd was affected by severe respiratory disease in one out of three pastures. At necropsy, Mycoplasma hyopneumoniae and Pasteurella multocida were detected in the lungs, as well as the lung worm Metastrongylus apri. The life cycle of Metastrongylus spp. includes earth worms as an intermediate host, and since domesticated pigs mainly are reared indoors lungworms has not been diagnosed in domestic pigs in Sweden for decades, not even in pigs reared outdoors. Therefore, this disease outbreak was scrutinised from the view of validating the impact of Metastrongylus spp..ResultsAt the time of the disease outbreak, neither eggs of Metastrongylus spp. nor Ascaris suum were detected in faeces of pigs aged ten weeks. In contrast, five-months-old pigs at the pasture with respiratory disease shed large amounts of eggs from Ascaris suum, whereas Ascaris suum not was demonstrated in healthy pigs aged six months at another pasture. Low numbers of eggs from Metastrongylus spp. were seen in faecal samples from both these age categories.At slaughter, seven weeks later, ten normal weighted pigs in the preceding healthy batch were compared with ten normal weighted and five small pigs from the affected batch. Healing Mycoplasma-like pneumonic lesions were seen in all groups. Small pigs had more white spot liver lesions, and all small pigs shed eggs of Ascaris suum in faeces, compared to around 50% of the pigs in the normally sized groups. Metastrongylus spp. were demonstrated in 13 of the 25 pigs (52%), %), representing all groups included.ConclusionAs Metastrongylus spp. were demonstrated regardless of health status, and in another healthy outdoor herd, the impact of Metastrongylus spp. on the outbreak of respiratory disease was depreciated. Instead, Metastrongylus spp. was suggested to be common in outdoor production, although rarely diagnosed. The reason for this is because they will escape detection at routine inspection at slaughterhouses, and that they appeared to generally not induce clinical signs of respiratory disease. Instead, a possible association with a high burden of Ascaris suum was suggested to have preceded the severe outbreak with respiratory disease.
Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Muscle Aging
Authors: WANG Huating , Zhao Yu , Ding Yingzhe , He Liangqiang , Li Yuying , Chen Xiaona , Sun Hao
Published: December 2021

3D genome rewiring is known to influence spatiotemporal expression of lineage-specific genes and cell fate transition during stem cell differentiation and aging processes. Yet it is unknown how 3D architecture remodels and orchestrates transcriptional changes during skeletal muscle stem cell (also called satellite cell, SC) activation, proliferation and differentiation course. Here, using in situ Hi-C we comprehensively map the 3D genome topology reorganization at multiscale levels during mouse SC lineage progression and integrate with transcriptional and chromatin signatures to elucidate how 3D genome rewiring dictates gene expression program. Specifically, rewiring at compartment level is most pronounced when SC becomes activated. Striking loss in TAD border insulation and chromatin looping also occurs during early activation process. Meanwhile, TADs can also form TAD clusters and super-enhancer containing TAD clusters orchestrate stage-specific gene expression during SC early activation. Furthermore, we elucidate 3D chromatin regulation of key transcription factor, PAX7 and identify cis-regulatory elements that are crucial for local chromatin architecture and Pax7 expression. Lastly, 3D genome remodeling is profiled in SCs isolated from naturally aging mice, unveiling that geriatric SCs display a prominent gain in long-range contacts and loss of TAD border insulation. Genome compartmentalization and chromatin looping are evidently altered in aged SC while geriatric SC display a more prominent loss in strength of TAD borders. Together, our results implicate 3D chromatin extensively reorganizes at multiple architectural levels and underpin the transcriptome remodeling during SC lineage development and SC aging.
Super Strong Wide TM Mie Bandgaps Tolerating Disorders
Authors: Goudarzi Kiyanoush , Lee Moonjoo
Published: December 2021

This study demonstrates the appearance of super intense and wide Mie bandgaps in metamaterials composed of germanium rods in air that tolerate some disordering of rod position and rod radius under transverse magnetic (TM) polarized light waves. Results for Mie bandgap modes TM01 and TM11 tolerate rod-position disordering of 50%, and rod-radius disordering of 34 and 20%, respectively. Using these characteristics of TM11 under position and radius disordering, ultra-narrow straight, L-shaped and crossing waveguides that contain 14, four, and two rows of Ge rods in air are designed. Also, it is shown that TE01 Mie bandgap appear in metamaterials contain high refractive index, and disappear in metamaterials with lower refractive index such as silicon; in contrast, a new phenomenon of intense and broadband TM01, TM11, and TM21 in metamaterials with lower refractive index such as silicon appear. Also, in Si-based metamaterials, TM01 tolerates high rod-position and rod-radius disordering of 50% and 34%, respectively, and TM11 shows robustness to rod-position and rod-radius of 20%. This strong tolerance of disordering of TM modes in silicon and germanium metamaterials opens a new way to design small, high-efficient, and easy-fabricable optical devices for optical integrated circuits.
Psychological Distress And Smoking Behaviors of Chinese College Students: Mediating Effects of The Dimensions of Learning Burnout
Authors: Li Xiong , Tan Yuhua , Li Shanqing , Wang Xiaoxin
Published: December 2021

Objectives: Smokers or never smokers exposed to environmental tobacco use (ETS) are usually associated with various diseases and cancers. In order to better help college students prevent the tobacco use and thus preclude the incidences of avoidable diseases, this study explored the predictive power of different variables including demographic and psychological variables in relation to smoking behaviors. Methods: Maslach Burnout Inventory-Student Survey (MBI-SS) and Kessler Psychological Distress Scale (K10) were used in this study. Results: The multivariate logistic regression indicated that college students who were male (versus female, OR = 9.55), majoring in medicine and sports (versus nursing, ORmedicine = 2.19, ORsports=2.81), born in the non-singleton family (versus singleton family, OR= 0.63) with higher family income (versus lower family income, OR = 0.45), surrounded with smoking friends (versus without smoking friends, OR= 0.18), were more vulnerable to smoke. In addition, combined with the theory of planned behavior (TPB), the dimensions of learning burnout had full mediation effects between psychological distress and smoking behavior. Conclusions: Psychological distress can only indirectly affect smoking behavior via learning efficacy, cynicism and emotional exhaustion. Adjustment from different dimensions of learning burnout will help college students better prevent the tobacco use.
Development And Validation of a Risk Scoring System to Predict Pneumothorax in CT-Guided Percutaneous Transthoracic Needle Biopsy
Authors: Yang Qiuhong , Luo Lin cheng , Peng Xinyi , Wei Hailong , Yi Qun , Luo Wei
Published: December 2021

Objective: To develop and validate a risk scoring system using variables easily obtained for the prediction of pneumothorax in CT-guided percutaneous transthoracic needle biopsy (PTNB).Methods: The derivation cohort was comprised of 1001 patients who underwent CT-guided PTNB. Multivariate logistic regression was used to identify risk factors for pneumothorax, which were treated as the foundation to develop the risk scoring system. To validate the system, a validation cohort group of 230 patients was enrolled.Results: Age, puncture times, puncture depth, smoking index, number of specimens, bleeding from the needle path, and lobular lesion were identified as risk factors in the derivation cohort. A risk scoring system (Hosmer-Lemeshow goodness-of-fit test p =0.33) was developed. The area under the receiver operating characteristic curve (AUROC) was 0.601 by using the risk score system. This risk score system demonstrated a better diagnostic effect with increasing age. In the group of patients older than 80 years, the AUROC was 0.76, showing good predictive power. This risk scoring system was confirmed in the validation cohort with an AUROC of 0.736.Conclusion: This scoring system has a good predictive effect in both derivation and validation cohort.
Octopamine Signaling Via Oamb is Essential for A Well-Orchestrated Climbing Performance of Adult Drosophila Melanogaster
Authors: El-Kholy Samar Ezzat , Afifi Basma , El-Husseiny Iman , Seif Amal
Published: December 2021

The biogenic amine octopamine (OA) orchestrates many behavioural processes in insects. OA mediates its function by binding to OA receptors belonging to the G protein-coupled receptors superfamily. Despite the potential relevance of OA for controlling locomotion, our knowledge about the role of each octopaminergic receptor still limited. In this study, RNA interference (RNAi) was used to knockdown each OA receptor type in almost all Drosophila melanogaster tissues using a tubP-GAL4 driver to investigate the loss of which receptor affects the climbing ability of adult flies. The results demonstrated that oamb-deficient flies had impaired climbing ability more than those deficient in other receptors receptive for OA. Targeted RNAi-mediated kockdown of oamb in the nervous system or muscular system decreased the climbing ability, indicating that within Drosophila legs, OA through oamb orchestrated the nervous system control and muscular tissue responses. Oamb-deficient adult males showed morphometric changes in the length and width of leg parts. Transmission electron microscopy revealed that the leg muscles oamb-deficient flies have severe ultrastructural changes compared to those of control flies. The severe impairment in the climbing performance of oamb-deficient flies correlates well with the completely distorted leg muscle ultrastructure in these flies. Taken together, we could conclude that OA via oamb plays an important role in the locomotor activity of Drosophila.
Proportions of Beneficial Factors in MLR, NLR, PLR and D-dimer in Preoperative Peripheral Blood of Patients With Early Stage Lung Cancer as Predictors of Patient Survival After Surgery
Authors: wang jun , li huawei , xu ran , lu tong , zhao jiaying , zhang Pengfei , qu lidong , zhang Shengqiang , guo Jida , zhang Linyou
Published: December 2021

ObjectiveThe purpose of this paper is to predict the following items. preoperative baseline monocyte-to-lymphocyte ratio (MLR)、neutrophil-to-lymphocyte ratio (NLR) Platura-to-lymphocyte ratio (PLR) and dimeric fibrin fragment D (D-dimer) associated with clinical outcome in patients with Early Lung Cancer (LC).MethodsWe performed a retrospective analysis of 376 patients with LC. Progression-free survival (PFS) and overall survival (OS) were assessed by Kaplan-Meier, and univariate and multivariate Cox regression analyses were performed to identify prognostic factors. Finally, multivariate Cox regression analysis was used to evaluate the influence of favorable factors on patients’ OS and PFS combined with the basic clinical characteristics of the patient ResultsAmong the variables screened by univariate Cox regression, MLR < 0.22, NLR < 1.99, PLR < 130.55 and D-Dimer < 70.5 (ng/ml) were significantly associated with both better OS and PFS. In multivariate Cox regression analysis, it was determined that MLR and D-Dimer had a better independent correlation with OS (p = 0.009, p = 0.05, respectively), while MLR was only better independently associated with PFS (P = 0.005). Furthermore, according to the number of favorable factors, patients with none of these factors had a significantly worse prognosis than patients with at least one of these factors.Conclusion﻿Baseline characteristics of low MLR, low NLR, low PLR and low D-dimer were associated with better outcomes.
Cascade position- torque control strategy based on function approximation technique (FAT) for flexible joint robots
Authors: Al-Shuka Hayder F.N. , Corves Burkhard , Abbas Ehab N.
Published: December 2021

This work deals with control of rigid link robotic manipulators provided with flexible joints. Due to presence of flexible joint dynamics, additional degrees of freedom and underactuation are developed that would complicate the control design. Besides, model uncertainties, unmodeled dynamics and disturbances should be considered in robot modeling and control. Therefore, this paper proposes a cascade position-torque control strategy based on function approximation technique (FAT). The key idea is to design two nested loops: 1) an outer position control loop for tracking reference trajectory, and 2) an inner joint torque control loop to track the desired joint torque resulted from the outer position loop. The torque control loop makes the robot system more adaptable and compliant for sudden disturbances. It increases the perception capability for the target robot mechanisms. Adaptive approximation control (AAC) is used as a strong tool for dealing with time-varying uncertain parameters and disturbances. A sliding mode term is easily integrated with control law structure; however, a constraint on feedback gains are established for compensating modeling (approximation) error. The proposed control architecture can be easily used for high degrees of freedom robotic system due to the decentralized behavior of the AAC. A two-link manipulator is used for simulation experiments.The simulated robot is commanded to move from rest to desired step references considering three cases depending on the selected value of the sliding mode time constant. It is shown that selection of a large time constant parameter related to the position loop leads to slow response. Besides, one of the inherent issues associated with the inner torque control is the presence of derivative of desired joint torque that makes the input control abruptly jumping at the beginning of the dynamic response. To end this, an approximation for derivative term of the desired joint torque is established using a low-pass filter with a time constant selected carefully such that a feasible dynamic response is ensured.The results show the effectiveness of the proposed controller.
Complete mineralization of acetic acid using catalytic ozonation with a high energy efficiency enhanced by MnO2/γ-Al2O3
Authors: Meng Ruiyun , Yao Shuiliang , Gao Erhao , Wu Zuliang , Li Jing , Du Erdeng
Published: December 2021

The complete mineralization of acetic acid in a biodegradation process is difficult due to the α-position methyl on the carboxyl group of acetic acid. This study explores the complete oxidation of acetic acid by catalytic ozonation. Metal oxides of MnO2, Co3O4, Fe3O4, and CeO2 loaded on γ-Al2O3 power were used as the catalysts. The experimental results showed that MnO2/γ-Al2O3 catalyst had the best mineralization performance for acetic acid. Typically, the mineralization of acetic acid is as high as 88.4% after 300 min ozonation of 100 mL of 1.0 g L‒1 acetic acid catalysed by 3.0 g 1.0wt.% MnO2/γ-Al2O3 catalyst powder with an energy efficiency of 15 g kWh‒1. However, without a catalyst, the mineralization of acetic acid is only 33.2% with an energy efficiency of 5.1 g kWh−1. The effects of MnO2 loading, catalyst dosage, acetic acid concentration, O3 concentration, ozonation temperature, and initial pH value of the acetic acid solution were systematically investigated. Radical quenchers and in-situ DRIFTS analyses indicated that •OH radical and reactive oxygen species on catalyst surface played an important role in the ozonation of acetic acid to CO2 and H2O. The mechanism of acetic acid oxidation on MnO2/γ-Al2O3 is proposed.
P. Edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer’s Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway
Authors: Cao Shu-qin , Aman Yahyah , Fang Evandro Fei , Tencomnao Tewin
Published: December 2021

Alzheimer’s disease (AD) is a common and devastating disease characterized by pathological aggregations of beta-amyloid (Aβ) plaques extracellularly, and Tau tangles intracellularly. While our understandings of the aetiologies of AD have greatly expanded over the decades, there is no drug available to stop disease progression. Here, we demonstrate the potential of P. edulis pericarp extract in protecting against Aβ-mediated neurotoxicity in mammalian cells and Caenorhabditis elegans models of AD. We show P. edulis pericarp protects against memory deficit, neuronal loss, and promotes longevity in the Aβ model of AD via stimulation of mitophagy, a selective cellular clearance of damaged and dysfunctional mitochondria. P. edulis pericarp also restores memory and increases neuronal resilience in a C. elegans Tau model of AD. While defective mitophagy-induced accumulation of damaged mitochondria contributes to AD progression, P. edulis pericarp improves mitochondrial homeostasis through NIX/DCT1-dependent mitophagy and SOD3-dependent mitochondrial resilience, both via increased nuclear translocation of the upstream transcriptional regulator FOXO3/DAF-16. Further studies to identify active molecules in P. edulis pericarp that could maintain neuronal mitochondrial homeostasis may enable the development of potential drug candidates for AD.
Simplified Chinese Version of the International Prostate Symptom Score and the Benign Prostatic Hyperplasia Impact Index: Cross-Cultural Adaptation, Reliability, and Validity for Patients with Benign Prostatic Hyperplasia
Authors: Dun Rong-liang , Mao Jian-min , Yu Chao , Zhang Qiang , Hu Xiao-hua , Zhu Wen-jing , Qi Guang-chong , Peng Yu
Published: December 2021

Purpose: The aim of this study was to translate and cross-cultural adapt the international prostate symptom score (IPSS) and benign prostatic hyperplasia impact index (BII) into simplified Chinese for mainland Chinese patients with benign prostatic hyperplasia (BPH).Methods: The original English IPSS and BII were translated into simplified Chinese versions, based on cross-cultural adaptation guidelines. Internal consistency was evaluated with Cronbach’ α, then test-retest reliability with intraclass correlation coefficients (ICCs) in stable patients. The validity of these two adaptations was tested by the correlation between the IPSS, and BII with visual prostate symptom score (VPSS), and 36 items Short Form Health Survey (SF-36). The floor and ceiling effects were calculated by the proportion of participants who obtained the highest and lowest possible score.Results: A total of 105 native Chinese-speaking patients with BPH were enrolled. Cronbach’ α were over 0.75 for the simplified Chinese IPSS (IPSS 0.815; IPSS-symptom 0.782), and 0.709 for the simplified Chinese BII, indicating acceptable internal consistency. The ICCs for the test-retest reliability were over 0.75 (IPSS, r = 0.836; IPSS-symptom, r = 0.801; IPSS-quality of life, r = 0.794; BII, r = 0.758), indicating excellent test-retest reliability. There were very good positive correlations between IPSS and BII (r = 0.605), as well as VPSS (r = 0.634), and very good or good negative correlations between IPSS-Qol and SF-36 physical functioning (r = -0.621), and vitality (r = -0.659), and between BII and SF-36 physical functioning (r = -0.421). No floor or ceiling effect was detected in the simplified Chinese IPSS and BII.Conclusions: This study indicates that the simplified Chinese IPSS and BII are reliable and valid measurement of the symptom and quality of life among Chinese patients with BPH, which is likely to be widely used in this population.
Clinicopathological significance and prognosis of long noncoding RNA SNHG14 expression in human cancers: A Meta-Analysis and bioinformatics analysis
Authors: Liu Bin , Lu Tingting , Wang Yongfeng , Chen Yaqiong , Ma Shixun , Jiao Yajun , Yang Kehu , Cai Hui
Published: December 2021

Background

SNGH14 is a recently found long non-coding RNA (lncRNA) with a strong link to cancer. However, it is uncertain if the expression of SNHG14 is linked to the prognosis of individuals with various forms of cancer. We conducted a meta-analysis of the available literature to evaluate the association between SNHG14 and clinicopathological characteristics and patient prognosis
Methods

The databases PubMed/Medline, Web of Science, Cochrane Library, and Embase were combed for relevant papers published till November 2021. The odds ratio (OR) and 95% confidence interval (CI) were used to analyze dichotomous variables, while the hazard ratio (HR) and 95% CI were employed as a summary statistic for survival outcomes. In addition, the Cancer Genome Atlas TCGA (TCGA) and gene expression omnibus (GEO) database were utilized to investigate SNHG14 differential expression in pan-cancers. Cox regression and Kaplan-Meier analysis were used to investigate the prognostic significance of SNHG14 in pan-cancer. The association between the degree of SNHG14 expression in pan-cancer and immune infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI) was measured using Spearman correlations.
Results

A total of 21 studies with 1,080 patients, mainly from China, were included. Our results showed that elevated SNHG14 expression was significantly associated with poor overall survival (OS) (HR = 1.39; 95% CI: 1.06-1.83; P = 0.017). In addition, increased SNHG14 expression was associated with tumor size (OR = 1.60; 95% CI: 1.20-2.14; P = 0.001), TNM staging (OR = 0.54; 95% CI: 0.40-0.71; P <0.001), lymph node metastasis (OR = 1.86; 95% CI: 1.35-2.55; P <0.001), differentiation grade (OR = 1.95; 95% CI: 1.36-2.80; P <0.001), and distant metastasis (OR = 2.44; 95% CI: 1.30 -4.58; P= 0.005). However, there was no significant difference in age (OR = 1.02; 95% CI: 0.77-1.33; P = 0.863) and gender (OR = 0.98; 95% CI: 0.72-1.35; P = 0.915).
Conclusion

This study revealed that overexpression of SNGH14 is associated with low OS rate and clinicopathological characteristics. SNGH14 can be considered as a new tumor marker that aids in early tumor diagnosis, thus improving the prognosis of patients.
TGTDCL Prepaid Domestic Gas Metering System & Reduction of System Loss in the Energy Sector of Bangladesh
Authors: Nargis
Published: December 2021

Titas Gas Transmission and Distribution Company Limited (TGTDCL) is the largest gas transmission and distribution company in Bangladesh. The company undertook a pilot project in July 2005 to implement pre-paid metering on a limited scale. The outcomes of the pilot project are analyzed and presented in this paper. Most of the customers under the project appear to be indifferent to the new system. The revenue of TGTDCL was less compared to the same number of un-metered customers. The pilot project has a lack of design, planning, and implementation errors. Calculations are therefore made based on the assumed parameters. Clear and conclusive results regarding the reduction of gas wastage and financial benefits are hard to determine.
Gut mucus layer degradation is associated with aggressive cervical cancer phenotype
Authors: Colbert Lauren E.
Published: December 2021

Background

Gut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, and increased gut diversity is associated with improved outcomes after treatment. We proposed that functions of specific microbial species adjoining the mucus layer may directly impact the biology of CC.
Results

In this study, we examined metagenomes of rectal swabs in 41 CC patients using whole-genome shotgun sequencing and found a significant association between molecular functions encoded by the metagenomes with markers of aggressive cancer including initial tumor size and stage. Profiling of the molecular function abundances and their distributions identified 2 microbial communities co-existing in each metagenome but with distinct metabolism and taxonomic structures. Community A (Clostridia and Proteobacteria predominant) was characterized by high activity of pathways involved in stress response, mucus glycan degradation and utilization of degradation byproducts. This community was prevalent in larger, advanced stage tumors. Conversely, community B (Bacteroidia predominant) was characterized by fast growth, active oxidative phosphorylation, and production of vitamins. This community was prevalent in small, early-stage tumors.
Conclusions

Based on these results, we propose that increased mucus layer degradation is associated with a more aggressive cervical cancer phenotype.
CEO hubris and Islamic banks’ performance: Investigating the roles of Sharia board vigilance and CEO power
Authors: Zulfikar Zulfikar , Nursiam Nursiam , Mujiyati Mujiyati , Nur Syamsiyati Rosida
Published: December 2021

The purpose of the study is to thoroughly outline how the hubris behavior of chief executive officers (CEO) is detrimental to Islamic banks’ (IBs) performance. Specifically, this study attempts to examine the role of the Sharia supervisory board (SSB), board vigilance, and CEO power in the relationship between CEO hubris behavior and decreased IBs’ performance. This study observes IBs’ performance during the period from 2014 to 2020 and develops eight models to test their determinants. Empirical testing of all models shows that CEO hubris has a detrimental impact on IBs’ performance. The moderating impact test shows the following results: firstly, the presence of SSB, which is represented by the reputation of its members, reduces the detrimental impact of hubris behavior by CEOs on IBs’ performance, while that impact, which is represented by member expertise, does not have a moderating effect. Second, the size and independence of the BOC both weaken the negative relationship between CEO hubris and IBs’ performance. Third, CEO power as represented by tenure and ownership has no moderating effect.
The Importance of the Role of Women Ulama as the Effort to Actualate the Message of Islam to the Value of Equality
Authors: Avivah Dewi
Published: December 2021

Islam is a gender-just religion so that in the dissemination of its values, gender-fair spaces and opportunities are also needed. The purpose of this study is to provide understanding and understanding to the reader that in realizing a gender-just environment, religion is an important slice that needs to be considered. Islam has agreed to create a gender-just order, and it has been stated in the verses of the Koran. This research method uses qualitative research, sourced from reading material and supported by implementation pictures as supporting data. The results showed that the presence of female clerics was very important. Islam has conveyed Islamic teachings by realizing gender justice so that resistance to patriarchal culture in Indonesia can be carried out with the presence of female ulama to understand that women also have human potential so that they can be said to be worthy as scholars. The limitation of this research is that the author is a little complicated in compiling the historical sequence of the presence of women ulama until their existence today. The lack of data sources that the author must obtain is still rare especially in research about Women Ulama as part of the struggle for gender equality.
The Application of Waqf and Endowment Fund Based on the Principles in the Sharia Maqashid Pillar Society
Authors: Wardhana Akhmad Kusuma
Published: December 2021

Islam regulates economic life for the benefit of all. Waqf can be a solution in creating mutual benefit in society. This study aims to analyze the comparison between the practice of waqf for both Muslims and non-Muslims. This study uses qualitative methods. Samples in this study are the Islamic Hospital of endowments and the Gates Foundation. Data were analyzed using descriptive-analytical methods. The results show that the Gates Foundation and UNISMA use funds from their business management to distribute to the public. If UNISMA distributes waqf funds for business development and to achieve goodness, the gates foundation is entirely donated to the public. The difference in the company's financial scale is this division.
The Role of NGO In Community Empowerment (Case Study LPPSLH Penderes Empowerment in Pasinggangan Village, Banyumas Regency)
Authors: Aprilia Dita , Widodo Ageng
Published: December 2021

Behind the life that we see in the capital city, it turns out that we still know the phenomenon of people's lives in rural areas who still depend on the natural resources around them. One of them is the phenomenon of coconut sugar farmers, who are often called penderes, who still cannot process coconut sap correctly and adequately to increase the selling value of the sugar. It is due to the low level of education and the lack of public knowledge in processing coconut sugar. LPPSLH is a non-government institution engaged in community empowerment, both urban and rural. With the phenomenon experienced by the farmers, LPPSLH as a facilitator, invites the farmers to take part in the organic certification program for ant sugar. Later, it can increase the farmers' income, increase the selling value of sugar, and market their products to the export market. The training and assistance aim to change farmers' behavior and old habits into more productive and profitable habits (efforts) to build farmers' independence. The method used in this research is descriptive-qualitative, and the sampling was collected purposively. The data collection technique used interviews, observation, and documentation. The results showed that LPPSLH played the role of education, facilitation, and advocacy to penderes farmers in empowerment programs, especially in rural areas.
Atık Kot Giysilerden İleri Dönüşüm Yöntemi ile Sanat Eseri Oluşturulması Deniz Sağdıç’ın Portre Çalışmalarının İncelenmesi
Authors: Binboğa Elif Burcu , Enes Esra
Published: December 2021

Tüketici sonrası atıklardan biri olan kot giysilerin ileri dönüşüm yöntemi ile bir sanat eseri olarak değerlendirilmesi süreci, atığı değerli bir materyal haline dönüştürür. Sanatın ve tasarımın disiplinlerarası çalışması ile kendi yaşam döngüsünü tamamlayan atık materyallere farklı alanlarda yeni bir yaşam döngüsüne sahip olmasını sağlayarak ikinci bir şans verebilir. İleri dönüşüm (upcycle) yöntemi hızlı moda tüketicisinin neden olduğu kot giysi atıklarından sanat eseri oluşturulması ile var olan kot giysi atıklarına inovatif bir çözüm sunarak modern bakış açısı sunmaktadır.
Günümüz modern dünyasında kot giysinin üretiminde çok fazla su tüketilmektedir. Bu nedenle yaşam döngüsünü tamamlamış kot giysi atıklarının ileri dönüşüm yöntemi ile değerlendirilebilmesi sürdürülebilirlik açısından büyük etkiye sahiptir. Bu araştırmada, ileri dönüşüm yöntemi ile sanat eseri oluşturulması konusu incelenmiş, ikinci el kot giysilerden modern sanat eseri oluşturan sanatçılar eserleri ile birlikte ele alınmış, kot giysi atıkları ile portre yapan Deniz Sağdıç’ın eserleri incelenerek yüz yüze görüşme yöntemi ile kendisinden bilgi elde edilmiştir.
Agroecology in the Brazilian Amazon. A Review
Authors: Souza Caio Cezar Ferreira de , Santos Marcos Antônio Souza dos , Rebello Fabrício Khoury , Martins Cyntia Meireles , Lopes Maria Lúcia Bahia , Barbosa Antônia do Socorro Aleixo , Saraiva Joyce dos Santos
Published: December 2021

Agroecological practices are alternatives for valuing and conserving the biodiversity of the Amazon as well as for integrating family farmers who survive from the exploitation of natural resources in the face of the expansion of large agricultural projects that have advanced in the region. In this respect, the objective of this study was to evaluate the scientific production related to agroecology in the Brazilian Amazon, in order to identify the main research gaps and set the foundations for new studies that will strengthen the debate on and policies to encourage sustainable agriculture. Our methodology was based on a systematic review of the literature using four academic research databases. The studies were published from 2000 to 2019. Through our database research, we obtained 36 articles that focused on agroecology in the Brazilian Amazon. Our results showed a certain level of diversity in terms of the geographic distribution of the municipalities included in the studies analyzed. Additionally, we detected diversity in terms of the dimensions addressed. For instance, reference was made to sustainable production systems based on agroecological principles, with emphasis on agroforestry systems. Additionally, socioeconomic and cultural aspects, such as the valuation of traditional knowledge and the importance of women in rural areas, were analyzed. Thus, the realization of in-depth studies that will analyze the process of agroecological transition with the use of different techniques, such as the statistical treatment of data and geoprocessing, can qualify agricultural production based on the agroecological practices in the Amazon.
Gobernanza y Persectivas sobre Acreditación y Calidade en la Formación Inicial Docente: Estudio en Universidades Chilenas
Authors: Cerna Cristhian , Fleet-Oyarce Nicholas , Pedraja-Rejas Liliana , Rodriguez-Ponce Emilio
Published: December 2021

El artículo analiza la relación entre calidad y acreditación en modelos de gestión universitaria desde la perspectiva de los actores. La metodología de investigación asumió el enfoque de teoría fundamentada, desde lo que se elaboró una muestra estructural representativa de tres casos de universidades chilenas con acceso a estudios de pregrado de élite, privadas de acceso masivo, y pública masiva, en torno a lo que se realizaron entrevistas semi-estructuradas y directivas, para proceder a un análisis axial. A partir de los resultados, describimos las teorías sustantivas de los actores en el sistema sobre acreditación y calidad, así como se formula una teoría formal al respecto de estas dimensiones claves del componente ideacional de la gobernanza educacional en el sistema terciario.
Gobernanza y Calidade en la Educación Superior: Una Descripción Bibliométrica
Authors: Pedraja-Rejas Liliana , Rodríguez-Ponce Emilio , Muñoz-Fritis Camila
Published: December 2021

Considerando que las universidades contemporáneas enfrentan una presión significativa para reestructurar sus prácticas de dirección, es que este artículo se propone como objetivo identificar las tendencias de la producción científica en relación a la gobernanza y la calidad en el campo de la educación superior. Para esto, se desarrolló un análisis bibliométrico de los artículos de revistas indexadas en Web of Science publicados entre los años 2010 y 2020. Para el análisis de datos y la visualización de mapas bibliométricos se utilizaron los programas computacionales Bibliometrix y VOSviewer. Los resultados evidencian un aumento en la producción científica si se comparan los años extremos del período analizado. Asimismo, se identificaron tres temas principales de investigación, a saber, 1) leyes y reformas a la educación superior, 2) percepciones de los académicos sobre las reformas, el nuevo escenario docente y sus niveles de satisfacción, y 3) compromiso y participación del estudiante. Se concluye que desde una perspectiva transversal el liderazgo de los directivos, la participación y el pensamiento crítico de los estudiantes, así como también la colaboración entre instituciones de educación superior son aspectos esenciales para que estas lleven a cabo sus roles con énfasis en la calidad.

Finalmente se proyecta un campo con publicaciones en aumento que aborden esta temática a partir del contexto de la educación superior en el que aspectos como la desregulación, la búsqueda de la calidad y la necesidad de autonomía financiera se perciben como necesidades urgentes.
Qualidade da Água na Proteção das Comunidades Aquáticas na Terra Indígena Rio Formoso, em Tangará da Serra-MT Região de Transição entre os Biomas Cerrado e Amazônia
Authors: Melo Martins Toledo de , Queiroz Tadeu Miranda de
Published: December 2021

Objetivou-se caracterizar as águas superficiais naturais disponíveis na Terra Indígena Rio Formoso em Tangará da Serra/MT-Brasil, conforme a Resolução 357/2005 do Conselho Nacional de Meio Ambiente (CONAMA), observando a sua possível destinação à proteção das comunidades aquáticas em Terras Indígenas. Foram escolhidas cinco bacias hidrográficas nas quais se identificou um ponto de amostragem próximo ao exutório, cujas coletas foram feitas em 12 campanhas no período de setembro/2016 a agosto de 2017, procurando realizá-las sempre próximo ao dia 15 de cada mês. As amostras foram obtidas seguindo as orientações de coleta e transporte, sendo refrigeradas desde a coleta até a entrega no laboratório onde foram analisadas em no máximo 24 horas. Neste estudo analisou-se 9 variáveis as quais constam na Resolução supracitada, quais sejam: Potencial Hidrogeniônico (pH); Cloreto (Cl); Fósforo total (P); Nitrogênio total (N); Demanda Bioquímica de Oxigênio (DBO); Oxigênio Dissolvido (OD); Sólidos totais (ST); Turbidez (Tu); e Coliforme Termotolerante (CT). Os resultados foram agrupados em dois períodos, sendo um seco (maio a outubro) e outro chuvoso (novembro a abril) e posteriormente foram apresentados pela média e desvio padrão amostral para cada ponto de coleta e período. As variáveis que contribuíram negativamente para os resultados foram: pH, oxigênio dissolvido e coliforme termotolerante. Todos os corpos de água deste estudo estão em desacordo com a Resolução 357/2005 para a classe 1 em pelo menos uma das variáveis avaliadas. A concentração das variáveis Cloretos, Fósforo, Nitrogênio, Demanda Bioquímica de Oxigênio, Sólidos Totais e Turbidez estão dentro dos limites da resolução de referência, se enquadram na Classe 1 e não apresentam limitação à preservação da vida aquática em terra indígena em nenhum dos pontos e períodos.
Analysis of the Possibilities for Improving the Environmental Legislation of Kazakhstan
Authors: Buribayev Yermek , Khamzina Zanna , Suteeva Canzada , Yermukanov Yerkin , Turlykhankyzy Kuralay , Kuttygalieva Anarkhan
Published: December 2021

The study describes the results of a study of environmental problems that limit socio-economic development in Kazakhstan. Changes in legislation, management decisions, and strengthening of control over compliance with environmental standards are proposed. The article examines the gaps in the legislative regulation of environmental safety and the policy at the national level. The recommendations outlined in the research will create conditions for ensuring a higher level of environmental protection, introduce a more effective system for the prevention and control of pollution and waste management, which will inevitably lead to a significant step-by-step improvement in the quality of the environment in the medium and long term, and as a result - to reduce the levels of morbidity and mortality, loss and decrease in the working capacity of the population caused by environmental pollution. Such positive social consequences will help reduce the losses in GDP associated with the above factors.
ENTRE LINHAS, TESOURAS E MÁSCARAS, COSTURANDO SOLIDARIEDADE
Authors: Cristina Souza Lacerda Melo de Souza Alice , Antunes Cleuza , Mendonça dos Santos Lima Andréia , Cristina Pereira Luciana
Published: December 2021

O relato descreve as ações desenvolvidas no projeto Entre linhas, tesouras e máscaras, costurando solidariedade, que teve por objetivo fortalecer a extensão no IFRO, por meio de parcerias para minimizar os efeitos da pandemia no município, com a confecção e distribuição de máscaras caseiras de tecido a grupos socialmente vulneráveis. Realizado em duas etapas o projeto foi desenvolvido  entre os meses de Maio de 2020 a Janeiro de 2021. Conclui-se que o projeto alcançou os objetivos propostos uma vez que as máscaras distribuídas alcançaram grupos vulneráveis colaborando para a  proteção dos indivíduos que  precisaram circular pela sociedade bem como os que ficaram isolados porém em grupos, como é o caso dos indígenas aldeados.

 

Palavras-chave: Ações de extensão; Prevenção; Corona Vírus; Máscaras de tecido.
REFLEXÕES ACERCA DE SEMINÁRIOS PERMANENTES COMO UM PROJETO DE EXTENSÃO UNIVERSITÁRIA NA PÓS-GRADUAÇÃO
Authors: Benassi Cassiane Beatrís Pasuck , Miguel Kassiana da Silva , Boscarioli Clodis , Klüeber Tiago Emanuel
Published: December 2021

A Extensão Universitária se constitui em um espaço de promoção e difusão do conhecimento científico, e nesse âmbito, os Seminários Permanentes do PPGECEM é um exemplo de projeto de extensão que visa promover discussão e divulgação de estudos e pesquisas desenvolvidos no âmbito das áreas de Educação em Ciências e Educação Matemática. Para tanto, esse artigo descreve e tece reflexões sobre as principais atividades realizadas no âmbito dos Seminários Permanentes do PPGECEM durante o seu primeiro quadriênio (2017 a 2020). A investigação de caráter qualitativa, utiliza da análise do tipo descritiva para o tratamento analítico dos dados. Os resultados indicam forte engajamento de docentes e discentes do Programa, assim como, relevante participação da comunidade externa nas mais diversas temáticas contempladas pelos seminários.