bluuebunny/crossref_metadata_2025 huggingface dataset:
Elevated pausing of RNA Polymerase II underlies acquired resistance to ionizing radiation
Authors: Yuan Kai , Liu Honglu , Yu Chunhong , Zhang Na , Meng Yang , Huang Canhua , Hu Chunhong , Chen Fang , Hu Xueying , Zhang Zhuohua
Published: November 2021

As the mainstay modality for many malignancies, ionizing radiation (IR) induces a variety of lesions in genomic DNA, evoking a multipronged DNA damage response to interrupt many cellular processes including transcription. How the global transcription cycle is altered by IR and whether it is contributing to the development of IR-resistance remain unaddressed. Here we report a genome-wide accumulation of paused RNA Polymerase II (RNAPII) after IR exposure. This increased pausing is partially maintained in cells acquired IR-resistance, notably on genes involved in radiation response and cell cycle, often leading to their downregulation. Individual knockdown some of these genes such as TP53 and NEK7 endows IR-sensitive cells with varying degrees of resistance, highlighting a novel link between elevated RNAPII pausing and the acquisition of IR-resistance. Accordingly, tuning-down the RNAPII pausing level by inhibiting CDK7 reverses IR-resistance both in cell culture and xenograft models. Our results suggest that modulation of the transcription cycle is a promising strategy to increase IR-sensitivity and thwart resistance.
The Intelligent Regulation Model of Oxytocin for Women Having Vaginal Birth After Cesarean Section
Authors: Hu Tingting , Zhang Yichao , Gao Rong , Li Jianhong , Yuan Zhengming , Lu Zhongqiu , Zhu Xiaoling
Published: November 2021

Objective: To build an intelligent regulation model of oxytocin (OT) for women having a vaginal birth after cesarean section (VBAC) and further explore the intelligent and precise regulation of the scheme of the OT medication at delivery. Methods: A cross-sectional study design was used by collecting the data of the VBAC parturitions who delivered in the Obstetrics Department of the First Affiliated Hospital of Wenzhou Medical University from January 2014 to May 2020 and used the OT during the labor process. The multiple linear regression was used to analyze the modeling variables from the electronic medical records and the variables such as fetal heart rate (FHR) and uterine contraction (UC) frequency extracted from the cardiotocography. The OT drip speed predictive model was established based on the XGBoost algorithm and was compared using the logistic regression model and traditional decision tree. The data set was divided into the training set and test set at the 8:2 ratio, and the predictive performance of the model was evaluated for the accuracy, precision, recall rate, and F1 score. Results: A total of 1005 records with oxytocin regulation were included from 124 parturitions involving the VBAC. The XGBoost model performed the best prediction. Through the five fold crossover operation, the accuracy was 0.82, precision was 0.84, the recall rate was 0.80, and the F1 value was 0.82. Among them, the contraction duration, uterine pressure, FHR, UC frequency, and interval time from the previous cesarean section were the variables with great contribution to the modeling.Conclusion: This study constructed an OT regulation model based on the XGBoost, which recognized that the real-time intelligent regulation of the prenatal OT, with fast response speed, high model accuracy, and strong extrapolation had positive significance to obstetric clinical nursing.
Fast nonlinear model predictive planner and control for an unmanned ground vehicle in the presence of disturbances and dynamic obstacles
Authors: Khan Subhan , Guivant Jose
Published: November 2021

This paper presents a solution for the tracking control problem, for an unmanned ground vehicle (UGV), under the presence of skid-slip and external disturbances in an environment with static and moving obstacles. To achieve the proposed task, we have used a path-planner which is based on fast nonlinear model predictive control (NMPC); the planner generates feasible trajectories for the kinematic and dynamic controllers to drive the vehicle safely to the goal location. Additionally, the NMPC deals with dynamic and static obstacles in the environment. A kinematic controller (KC) is designed using evolutionary programming (EP), which tunes the gains of the KC. The velocity commands, generated by KC, are then fed to a dynamic controller, which jointly operates with a nonlinear disturbance observer (NDO) to prevent the effects of perturbations. Furthermore, pseudo priority queues (PPQ) based Dijkstra algorithm is combined with NMPC to propose optimal path to perform map-based practical simulation. Finally, simulation based experiments are performed to verify the technique. Results suggest that the proposed method can accurately work, in real-time under limited processing resources.
Construction of a circRNA - Mediated ceRNA Network Reveals Novel Biomarkers for Aortic Dissection
Authors: Liu De-Bin , He You-Fu , Chen Gui-Jian , Huang Hua , Xie Xu-Ling , Lin Wan-Jun , Peng Zhi-Jian
Published: November 2021

Background
Aortic dissection (AD) is a rare and lethal disorder with its genetic basis remains largely unknown. Many studies have confirmed that circular RNAs (circRNAs) play important roles in various physiological and pathological processes. However, the roles of circRNAs in AD are still unclear and need further investigation. The present study aimed to elucidate the underlying molecular mechanisms of circRNAs regulation in aortic dissection based on the circRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network.
Methods
Expression profiles of circRNAs (GSE97745), miRNAs (GSE92427), and mRNAs (GSE52093) were downloaded from Gene Expression Omnibus (GEO) databases, and the differentially expressed RNAs (DERNAs) were subsequently identified in AD by bioinformatics analysis. Further bioinformatics analyses, including circRNA-miRNA-mRNA ceRNA network, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, were used to predict the potential functions of circRNA-associated ceRNA regulatory network. RNA was isolated from human arterial blood samples after which quantitative real-time PCR (qRT-PCR) was performed to confirm the DERNAs.
Results
We identified 14 (5 up-regulated and 9 down-regulated) differentially expressed circRNAs (DEcircRNAs), 17 (8 up-regulated and 9 down-regulated) differentially expressed miRNAs (DEmiRNAs) and 527 (297 up-regulated and 230 down-regulated) differentially expressed mRNAs (DEmRNAs) when AD samples were compared with normal ascending aorta samples (adjusted P-value < 0.05 and | log2FC |> 1.0). KEGG pathway analysis indicated that DEmRNAs were related to focal adhesion and extracellular matrix (ECM) receptor interaction signaling pathways. Simultaneously, the present study successfully constructed a ceRNA regulatory network based on 1 circRNAs (hsa_circRNA_082317), 1 miRNAs (hsa-miR-149-3p) and 10 mRNAs (MLEC, ENTPD7, SLC16A3, SLC7A8, TBC1D16, PAQR4, MAPK13, PIK3R2, ITGA5, SERPINA1) in AD. Furthermore, qRT-PCR demonstrated that hsa_circRNA_082317 andα5 integrin (ITGA5) were significantly up-regulated in AD (n = 3), and hsa-miR-149-3p was dramatically down-regulated in AD (n = 3). The expression of hsa-miR-149-3p target mRNA, ITGA5, was positively modulated by hsa_circRNA_082317.
Conclusion
This is the first study to demonstrate the circRNA-associated ceRNA regulatory network is altered in AD, implying that circRNAs may play important roles in regulating the onset and progression of AD and thus may serve as potential biomarkers for the diagnosis and treatment of AD.
Tanshinone ⅡA Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Myocardial Ischemia/reperfusion Injury via Up-regulating miR-223-5p
Authors: Li Sheng , Li Lan , Guo Rui , Cao Weilong , Liu Zhihao , Zhang Jing , Liu Qianqian , Huang Yuting , Ma Chuanrui , Fan Guanwei
Published: November 2021

Background: Myocardial ischemia-reperfusion (I/R) injury is a serious obstacle for patients with coronary heart disease to benefit from post-ischemic reflow. After myocardial I/R injury, CCR2+-resident macrophages are rapidly activated and participate in the subsequent inflammatory response, whereas CCR2--resident macrophages play a major role in attenuating cardiac inflammation and promoting tissue repair. Mesenchymal stem cells (MSCs) have gradually become attractive candidates that aid in understanding the pathogenesis and progression of cardiovascular diseases. The low immunogenicity and low carcinogenicity of stem cell-derived exosomes offer advantage in treating myocardial injuries. In this study, we investigated whether MSC-derived exosomes pretreated with tanshinone IIA (TSA) could exhibit stronger cardioprotective function in an I/R rat model and explored its underlying mechanism. Methods: We investigated the effect of TSA-MSCexo on myocardial I/R injury in vivo. The overexpression of CCR2 in the rat heart was used to determine the regulatory role of CCR2 in I/R injury. High-throughput sequencing of MSCexo and TSA-MSCexo to screen differential genes to explore the mechanism of TSA-MSCexo's cardioprotective effect. Results: Compared with MSCexo, an intramyocardial injection of TSA-MSCexo was found to be more effective in rats in improving cardiac function, limiting the infarct size, inhibiting CCR2 activation, reducing monocyte infiltration and promoting angiogenesis in the heart after myocardial I/R. Moreover, CCR2 had a regulatory effect on monocyte infiltration and angiogenesis after I/R. Bioinformatics analysis and miRNA sequencing of MSCexo and TSA-MSCexo revealed miR-223-5p an effective candidate mediator for TSA-MSCexo to exert its cardioprotective function and CCR2 as the downstream target. Conclusion: In summary, our findings indicated that miR-223-5p packaged in TSA-MSCexo inhibited CCR2 activation to reduce monocyte infiltration and enhanced angiogenesis to alleviate myocardial I/R injury in rats. Thus, the development of an alternative therapy of TSA combined with stem cell-derived exosomes provides an effective strategy for the clinical therapies of ischemic cardiomyopathy.
Parallel processes of temporal control in the supplementary motor area and the frontoparietal circuit
Authors: Wang Xuanyu , Shi Shunyu , Bao Yan
Published: November 2021

Durations in the several seconds' range are cognitively accessible during active timing. Functional neuroimaging studies suggest the engagement of basal ganglia (BG) and supplementary motor area (SMA). However, their functional relevance and arrangement remain unclear because non-timing cognitive processes temporally coincide with the active timing. To examine the potential contamination by parallel processes, we introduced a sensory control and a motor control to the duration reproduction task. By comparing their hemodynamic functions, we decomposed the neural activities in multiple brain loci linked to different cognitive processes. Our results show a dissociation of two cortical neural circuits: the SMA for both active timing and motor preparation, followed by a prefrontal-parietal circuit related to duration working memory. We argue that these cortical processes represent duration as the content but at different levels of abstraction, while the subcortical structures including BG and thalamus provide the logistic basis of timing by coordinating temporal framework across brain structures.
A roadmap to better COVID-19 testing from the Coronavirus Standards Working Group
Authors: Mercer Tim , Almond Neil , Chain Patrick , Crone Michael , Deshpande Alina , Eveleigh Deepa , Freemont Paul , Fuchs Sebastien , Garlick Russell , Huggett Jim , Kammel Martin , Li Po-E , Milavec Mojca , Marlowe Elizabeth , O’Sullivan Denise , Page Mark , Pestano Gary , Suliman Sara , Simen Birgitte , Sninsky John , Sopchak Lynne , Tato Cristina , Vandesompele Jo , Vallone Peter , White Thomas , Zeichhardt Heinz , Salit Marc , mistake no
Published: November 2021

Testing has been central to our response to the COVID-19 pandemic. However, the accuracy of testing relies on standards, including reference materials, proficiency testing schemes, and information and reporting guidelines. The use of standards is a simple, inexpensive, and effective method to ensure reliable test results that inform clinical and public health decisions. Here we describe the central role of standards during the COVID-19 pandemic, where they have enabled population-scale screening, genomic surveillance and measures of immune protection measures. Given these benefits, the Coronavirus Standards Working Group (CSWG) was formed to coordinate standards in SARS-CoV-2 testing. This network of scientists has developed best-practices, reference materials, and conducted proficiency studies to harmonize laboratory performance. We propose that this coordinated development of standards should be prioritized as a key early step in the public health response to future pandemics that is necessary for reliable, large-scale testing for infectious disease.
The Effect Of Malignant Breast Tissue Stromal Cells On The Growth Of Cancer Cells And The Relationship Of miRNA
Authors: UÇAR Özlem SAĞLAM , SAĞLAM-UÇAR Özlem , DEĞİRMENCİ İrfan , HALBUTOĞULLARI Zehra Seda , PÖSTEKİ Gökhan , SUBAŞI-DEMİRCİ Cansu , ERMAN Gülay , KARAÖZ Erdal , UTKAN Nihat Zafer
Published: November 2021

Purpose

Inflammatory signals secreted from the tumor microenvironment are thought to promote tumor growth and survival. It has been reported that stromal cells in the tumor microenvironment have similar characteristics to tumor-associated cells. In addition to miRNAs play critical roles in various diseases, including cancer. In this study, we aimed to investigate the effects of co-culture of cancer cells and stromal cells isolated from normal and malignant breast tissue on each other and the possible effects of miRNAs on these interactions.
Methods

The characterized stromal cells were co-cultured with an MDA-MB-231 cancer cell line. The proliferation capacity of the experimental groups was evaluated using the WST-1 assay. The expression of breast cancer-specific miRNAs and related genes were assessed by real-time PCR. ELISA assay was performed to determine the concentration of some cytokines and chemokines.
Results

We found that the microenvironment plays an important role in the development of cancer, confirming the changes in the expression of oncogenic and tumor-suppressor miRNA and their target genes after co-culture with malignant stromal cells.
Conclusion

As a result of the studies, specific gene expressions of related signaling pathways were detected in correlation with miRNA changes and the effects of tumor microenvironment on tumorigenesis were revealed in detail. miRNAs have been shown to play an important role in cancer development in recent studies. The idea that these small molecules can be used in diagnosis and treatment is becoming stronger day by day. We believe that new treatment approaches involving the tumor microenvironment and using miRNAs as markers are promising.
WITHDRAWN: Elimination Study of Methylene Blue Dye Using PANI and PANI/SiO2 Composite.
Authors: Abderrahim BENSEDIRA , Nacerddine HADDAOUI , Rachida DOUFNOUNE , Ouahiba MEZIANE , Labidi N. S.
Published: November 2021

Conducting Polymeric composites have attracted great attention over the last years because of their potential uses in chemical, electronic and optical devices, and as catalysts as well as in adsorption processes. Chemical synthesis of polyaniline (PANI) and polyaniline-SiO2 composite and their adsorptive performance were reported in the present work. These materials were prepared and evaluated for their methylene blue (MB) dye adsorption characteristics from aqueous solution. Adsorption equilibrium kinetic and thermodynamic experiments of MB onto PANI and PANI/SiO2 were studied. The effects of initial dye concentration, contact time and temperature on the adsorption capacity of PANI/SiO2 for MB have been investigated. The pseudo-first order and pseudo-second order kinetic models were used to describe the kinetic data. It was found that adsorption kinetics followed the pseudo-second order at all of the studied temperatures. The Langmuir, Freundlich and Dubinin Raduschkevich adsorption models were used for the mathematical description and the fit obtained using the Dubinin Raduschkevich isotherm has a medium R2 value.
Forecasting Photosynthetic Photon Flux Density Under Cloud Effects: Novel Predictive Model Using Convolutional Neural Network Integrated With Long Short-term Memory Network
Authors: Deo Ravinesh C , Grant Richard H , Webb Ann , Ghimire Sujan , Igoe Damien P. , Downs Nathan J. , Al-Musaylh Mohanad S , Parisi Alfio V. , Soar Jeffrey
Published: November 2021

Forecast models of solar radiation incorporating cloud effects are useful tools to evaluate the impact of stochastic behaviour of cloud movement, real-time integration of photovoltaic energy in power grids, skin cancer and eye disease risk minimisation through solar ultraviolet (UV) index prediction and bio-photosynthetic processes through the modelling of solar photosynthetic photon flux density (PPFD). This research has developed deep learning hybrid model (i.e., CNN-LSTM) to factor in role of cloud effects integrating the merits of convolutional neural networks with long short-term memory networks to forecast near real-time (i.e., 5-minute) PPFD in a sub-tropical region Queensland, Australia. The prescribed CLSTM model is trained with real-time sky images that depict stochastic cloud movements captured through a Total Sky Imager (TSI-440) utilising advanced sky image segmentation to reveal cloud chromatic features into their statistical values, and to purposely factor in the cloud variation to optimise the CLSTM model. The model, with its competing algorithms (i.e., CNN, LSTM, deep neural network, extreme learning machine and multivariate adaptive regression spline), are trained with 17 distinct cloud cover inputs considering the chromaticity of red, blue, thin, and opaque cloud statistics, supplemented by solar zenith angle (SZA) to predict short-term PPFD. The models developed with cloud inputs yield accurate results, outperforming the SZA-based models while the best testing performance is recorded by the objective method (i.e., CLSTM) tested over a 7-day measurement period. Specifically, CLSTM yields a testing performance with correlation coefficient r = 0.92, root mean square error RMSE = 210.31 μ mol of photons m-2 s-1, mean absolute error MAE = 150.24 μ mol of photons m-2 s-1, including a relative error of RRMSE = 24.92% MAPE = 38.01%, and Nash Sutcliffe’s coefficient ENS = 0.85, and Legate & McCabe’s Index LM = 0.68 using cloud cover in addition to the SZA as an input. The study shows the importance of cloud inclusion in forecasting solar radiation and evaluating the risk with practical implications in monitoring solar energy, greenhouses and high-value agricultural operations affected by stochastic behaviour of clouds. Additional methodological refinements such as retraining the CLSTM model for hourly and seasonal time scales may aid in the promotion of agricultural crop farming and environmental risk evaluation applications such as predicting the solar UV index and direct normal solar irradiance for renewable energy monitoring systems.
Projected number of osteoarthritis patients in Austria for the next decades – quantifying the necessity of treatment and prevention strategies in Europe
Authors: Hitzl Wolfgang , Stamm Tanja , Kloppenburg Margreet , Ritter Markus , Gaisberger Martin , Zee-Neuen Antje van der
Published: November 2021

Background
The present study aimed to predict the expected number of patients with osteoarthritis (OA) in Austria up to the year 2080.
Methods
Demographic data and population projections between 2019 and 2080 were obtained from European authorities. Information about recent age- and sex-stratified prevalence of patients with self-reported physician-diagnosed OA was obtained from the Austrian Health Interview Survey (n=15,771). Projections were stratified by age and sex; sensitivity analyses were performed based on aging (lower), main (most likely), and growth (upper) scenarios of the population.
Results
Based on the projection, the overall increase in the total number of patients with OA from 2019 to 2080 will be 38% for men and women. In 2019, the highest number of OA-patients nested in the groups of persons aged 70-79 (n=238,749) and 60-69 (n=237,729) years. In 2080, the 80+ age group is predicted to have the highest number of OA with 421,548 individuals (i.e. factor 3.45 and factor 2.48 increase in the male and female group, respectively, compared to 2019), followed by the group aged 70-79 with 314,617 individuals (factor 1.45 and factor 1.28 increase in the male and female group, respectively, compared to 2019). Similar trends were found in the ageing and growing scenarios.
Conclusions
The projected increase in the occurrence of OA will likely lead to a substantial socioeconomic burden for the Austrian healthcare system in the near and far future. The current findings plead for the development of sustainable concepts for the treatment and prevention of OA by European authorities.
Success and Failure Factors for Trabeculectomy in Glaucomatous Patients in Southwest China: A 325 Eyes Analysis
Authors: Qin Zuoxin , Ying Xi , Han Qing , Wang Lu , Tan Lian , Xu Yufei , Wu Nan , Liu Yong
Published: November 2021

Purpose
To evaluate the outcomes and elucidate the success and failure factors for trabeculectomy with mitomycin C (MMC) in Southwest Chinese patients.
Methods
A retrospective correlational study was conducted on the glaucomatous patients who underwent initial trabeculectomy with MMC in Southwest Hospital and had been followed up for 1-3 years. A complete success for surgery is defined as a postoperative intraocular pressure (IOP) > 5 and ≤ 21 mmHg and 20% reduction of IOP compared to preoperative, without IOP-lowering medications. A qualified success for surgery is defined as the abovementioned postoperative IOP with or without IOP-lowering medications. The primary outcomes were IOP, the number of IOP-lowering medications, and cumulative success rate. The secondary outcomes included best corrected visual acuity (BCVA), mean deviation (MD) of visual field, major complications, and risk factors for surgical failure.
Results
A total of 325 eyes of 261 glaucomatous patients had been included in our study. Both the mean IOP and the number of IOP-lowering medications were significantly decreased from 32.9 ± 12.0 mmHg to 16.4 ± 5.7 mmHg (P<0.0001) and 3.0 ± 0.9 to 0.9 ± 1.0 (P<0.0001), respectively, at the last visit. The cumulative complete success rate and qualified success rate were 77.8% and 92.0% at 1-year follow-up, and 47.2% and 77.7% at 3-year follow up. There were no significant differences in surgical outcomes between primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG). In PACG patients, the success rates of trabeculectomy were comparable with those of phacotrabeculectomy. Hypertension (HR=1.904, P=0.011), encapsulated bleb (HR=2.756, P<0.001), and more preoperative topical medications (HR=2.475, P=0.008) were risk factors for surgical failure.
Conclusions
The qualified success rate of trabeculectomy with MMC in glaucomatous patients in Southwest China is 92.0% at 1-year follow-up, and 77.7% at 3-year follow up. Hypertension, encapsulated bleb, and more preoperative topical medications are associated with surgical failure.
The Prevalence of HER2 Positivity In HER2 Borderline Tumors In Iranian Breast Cancer Patients And Predictive Variables
Authors: Omranipour Ramesh , Nazarian Newsha , Alipour Sadaf , Ebrahimi Amirpasha , Eslami Bita
Published: November 2021

Background: Human epidermal growth receptor-2 (HER2) gene amplification is an important predictive and prognostic factor in breast cancer treatment. However, the expression of HER2 by immunohistochemistry (IHC) is determined as borderline in some cases and confirmation of the HER2 status by in situ hybridization either fluorescent (FISH) or bright field chromogenic (CISH) is necessary for correct treatment decision-making. Considering the high cost of FISH and CISH, we aimed to investigate whether the HER2 status could be predicted by other histological and cellular characteristics of the tumor by evaluating the association of these characteristics with the actual tumor HER2 status. Methods: Data of 438 breast cancer patients with IHC-determined HER-2 borderline disease was evaluated retrospectively. FISH or CISH results, pathologic tumor size and type, node involvement, Ki67%, presence of estrogen and progesterone receptor (ER, PR), HER2 status, lymphovascular invasion (LVI), perineural invasion (PNI), and stage were retrieved from clinic records. Results: Seventy-four (16.9%) patients had positive results for HER2 status with FISH or CISH. Logistic regression analysis showed that the pathologic size had a positive association with HER2 positivity with an OR equal to 1.03 (Odds ratio (OR):1.03, 95% CI: 1.01-1.05). In addition, the adjusted OR illustrated a statistically significant association between HER2 positivity and PR negativity (OR=2.14, 95% CI: 1.14-4.02). The invasive lobular carcinoma histology had a reverse association with HER2 positive status, with a borderline significance level (OR=0.15, 95% CI: 0.02-1.18).Conclusion: We could not find an applicable model to predict the actual status of HER2 in borderline cases and still, we have to recommend further assay by FISH or CISH in these patients.
De Novo Protein Design of Photochemical Reaction Centers
Authors: Ennist Nathan , Zhao Zhenyu , Stayrook Steven , Discher Bohdana , Dutton P Leslie 'Les' , Moser Christopher
Published: November 2021

Natural photosynthetic protein complexes capture sunlight to power the energetic catalysis that supports life on Earth. Yet these natural protein structures carry an evolutionary legacy of complexity and fragility that encumbers protein reengineering efforts and obfuscates the underlying design rules for light-driven charge separation. De novo development of a simplified photosynthetic reaction center protein can clarify practical engineering principles needed to build new enzymes for efficient solar-to-fuel energy conversion. Here we report the rational design, X-ray crystal structure, and electron transfer activity of a multi-cofactor protein that incorporates essential elements of photosynthetic reaction centers. This highly stable, modular artificial protein framework can be reconstituted in vitro with interchangeable redox centers for nanometer-scale photochemical charge separation. Transient absorption spectroscopy demonstrates Photosystem II-like tyrosine and metal cluster oxidation, and we measure charge separation lifetimes exceeding 100 ms, ideal for light-activated catalysis. This de novo-designed reaction center builds upon engineering guidelines established for charge separation in earlier synthetic photochemical triads and modified natural proteins, and it shows how synthetic biology may lead to a new generation of genetically encoded, light-powered catalysts for solar fuel production.
Akademische Mediennutzung Studierender im Corona-Semester 2020
Authors: Bedenlier Svenja , Händel Marion , Kammerl Rudolf , Gläser-Zikuda Michaela , Kopp Bärbel , Ziegler Albert
Published: November 2021

Unter dem Eindruck der CoViD-19 Pandemie erfolgte im Sommersemester 2020 an deutschen Hochschulen flächendeckende Online-Lehre im Notbetrieb. Die vorliegende längsschnittliche Fragebogenstudie untersucht die akademische Mediennutzung, -kompetenz und -ausstattung Studierender (N = 2.037) an einer deutschen Volluniversität zu Beginn und zur Mitte des betreffenden Semesters. Die Ergebnisse zeigen, dass die akademische Mediennutzung intensiviert wird, wahrgenommene digitale Kompetenzen der Studierenden zunehmen und E-Learning Angebote fakultätsspezifisch eingesetzt und genutzt werden. Sichtbar wird jedoch auch, dass Studierende mit heterogenen Voraussetzungen in das Semester starteten, die sich auch im Semesterverlauf auf die Studiensituation auswirkten. Die Ergebnisse werden vor dem Hintergrund bildungspolitischer Bestrebungen hinsichtlich der Digitalisierung der Hochschullehre, mediendidaktischer Fragestellungen und studentischem Eigensinn der Mediennutzung eingeordnet und diskutiert.
This is simplified to the point of banality.
Authors: Jaki Sylvia
Published: November 2021

This study offers a contribution to the reception analysis of TV doc­umentaries by focusing on viewer opinions expressed on social me­dia. It analyses German and English comments from YouTube and Facebook in order to find out what aspects of documentaries the audience comments on. More specifically, it describes how the viewers evaluate strategies that the producers use for simplifying complex content while still creating an appealing and entertaining media product. The results imply that most viewers appreciate informative shows that are entertaining at the same time. They also show that viewers tend to focus on the music and image, rather than on the spoken text, and that documentaries where nature plays an important role are judged more positively than science and history documentaries.
CATALYSTS OF BARBARIZATION AND DEBARBARIZATION IN CLASSICAL ATHENS
Authors: СУРИКОВ И.Е.
Published: November 2021

В качестве факторов, способствовавших нарастанию варваризации в Афинах второй полвины V в. до н.э., в статье указываются создание Афинской морской державы, движение софистов, конфликт поколений, Пелопоннесская война, наступление «эры демагогов». Обратное же движение в сторону деварваризации (с самого конца Vв. до н.э.) было связано в первую очередь с возрождением уважения к законности, с укреплением стабильности и порядка. Новая афинская демократия IV в. до н.э., которую одни специалисты считают «усовершенствованным» вариантом по сравнению с демократией предшествующего столетия, а другие, напротив, ее упадком, кризисом, была в основном свободна как от охлократических, так и от олигархических тенденций; она может с полным основанием быть определена как умеренная демократия, в отличие от радикальной демократии второй половины V в. до н.э. Конфликтов не то чтобы не было, но их старались разрешать мирным путем, по возможности достигая компромисса и избегая насилия.

The article cites as factors, which promoted the growth of barbarization in Athens in the last half of the 5thcentury B.C., the following ones: the emergence of the Athenian Empire, the sophistic movement, the conflict of generations, the Peloponnesian War, and the coming of the “era of demagogues”. As to the reverse motion towards debarbarization (from the very end of the 5th century B.C.), it was connected, in the first instance, with revival of the lawfulness’ authority and with strengthening order and stability. The new Athenian democracy of the 4thcentury B.C. (which is considered by some scholars an “improved” version as compared with democracy of the previous century, but by other scholars, on the contrary, its decline and crisis) was in general free from both ochlocratic and oligarchic tendencies; it may be with good reason defined as a moderate democracy, as distinct from the radical democracy of the last half of the 5thcentury B.C. It is not to say that there were no conflicts, but people sought to solve them by peaceful way, as far as possible, to reach compromises and to avoid violence.
MODERN CIVILIZATION AND DESTRUCTION OF AN INDIVIDUAL'S COGNITIVE MAP
Authors: БУДАНОВ А.В.
Published: November 2021

В статье на основе публикаций в масс-медиа и Интернет-блогах анализируется трансформация когнитивной карты личности в современных условиях. Показаны основные направления и риски деструктивного воздействия на человека информационного поля. По мере становления новой цивилизации XXI века информационное поле ускоряет процесс придания современному варварству особого метафизического смысла, нарушающего допустимые нормы и пределы, свойственные любой цивилизации. Выделены триггеры, стратегии и технологии, запускающие у человека процессы кардинального изменения его мироощущения и миропонимания. Социально-психологический ракурс исследования позволяет по-новому взглянуть на природу и сущность современного варварства. Показаны возможные формы прогнозирования социального поведения человека в контексте появления и преодоления агрессивных злонамеренных действий.

The article is devoted to the analysis based on mass media publications and internet blogs of an individual's cognitive map transformation in modern realities. General directions and risks of information field destructive impacts on an individual are shown. As new civilization of XXI century establishes, information field gives a boost to a process of giving special metaphysical meaning to modern barbarity, which destructs permissible social norms common to an any civilization. Triggers, strategies, and technologies, starting fundamental changing processes in world perception and mentality of an individual are summarized. Social and psychological view of the article lets take a fresh look at an essence and nature of modern barbarity. Possible forms of conceptual foresight of individual's social behavior are shown in context of materialization and overriding of aggressive and ill-destined moves.
ROMAN EXPANSION AS A «TRIGGER HOOK» OF MIGRATIONS PROCESSES ON BOSPOR UNDER KING ASANDER IN THE CONTEXT OF ALLIES WITH THE BARBARIANS
Authors: ЯРЦЕВ С.В. , ЗУБАРЕВ В.Г.
Published: November 2021

В то время, когда Римская империя вышла на просторы Северного Причерноморья, на Боспоре к власти пришел царь Асандр (47–17 гг. до н.э.). Он стал неуклонно следовать курсу на поддержку царского землевладения и развитию дружественных отношений с варварским миром. К концу его правления вся царская земля покрылась укрепленными военно-хозяйственными поселениями с варварскими гарнизонами, а по всему периметру боспорских границ расположились союзные племена. Некоторые из них, расселенные по всем стратегическим местам созданной Асандром фортификационной системы, получили наименование тафрии, так как несли службу в местах, связанных с термином «тафрос» и являлись выходцами из тавроскифской среды. Усиление миграционных процессов на Боспоре и улучшение отношения с варварами в данное время, авторами объясняются римским давлением на государство.

At the time, when the Roman Empire came to the expanses of the Northern Black Sea region, Tsar Asander (47–17 BC) start to power in the Bospor. He began to steadily follow the course of supporting the tsar land tenure and developing friendly relations with the barbarian world. By the end of his reign, the entire tsar land was covered with fortified military-economic settlements with barbarian garrisons, and allied tribes were located along the entire perimeter of the Bospor borders. Some of them, settled in all the strategic places of the fortification system, created by Asander, received the name tafria, since they served in places associated with the term “tafros” and were from the Tavro-Scythian environment. The strengthening of migration processes on the Bosporus and the improvement of relations with the barbarians at this time, the authors explain the Roman pressure on the state.
The institute of statutory limitation in criminal procedure and in criminal law
Authors: Maloku Elda
Published: November 2021

The institute of statutory limitation in criminal procedure has an extreme importance and through this research we will get to know more about the new provisions of Criminal Procedure Code and the Criminal Code of Republic of Kosovo regarding the statute of limitations of the criminal prosecution and the statute of limitations of the execution of the criminal-legal sanctions.
The object of research: Analysis and the synthesis facts and essential legal provisions of Criminal Procedure and the Criminal Code of the Republic of Kosovo for statutory limitation (hereinafter SoL), by using scientific theory, methodology and scientific research in order to gain scientific knowledge.
The main scientific results: The institute of statutory limitation in the Criminal Procedure in the Republic of Kosovo is analyzed with the provisions of the Criminal Code and Criminal Procedure Code. Moreover, SoL is analyzed and compared with legal provisions in the abolished Criminal Code and the new Criminal Code of Republic of Kosovo as well. Improvement of the efficiency of the Institute of SoL in criminal law and criminal procedure has been found through new amendments to the legal provisions of the Code of Criminal Procedure and the Criminal Code
The area of practical use of the research results: Are the newest data for the institute of SoL in the criminal procedure and in criminal law as well. The conducted research made it possible for lawyers, criminologists, victimologists, Non-Governmental Organizations (hereafter: NGOs) and all stakeholders to obtain additional information about the Institute of SoL in Criminal Procedure Law and Criminal Law in the Republic of Kosovo.
Innovative technological product: Identification and the analysis of new changes in legal provisions of Criminal Procedure Code and Criminal Code of the Republic of Kosovo for efficiency improvement of SoL institute.
Scope of the innovative technological product: This research will contribute and fulfill the scientific knowledge fund on the SoL problem in Kosovo and its enforcement. Also, the research results can create some starting points for more complex scientific research in the future for the Institute of SoL in the Republic of Kosovo or in the other countries of the region.
The empirical evidence on negating turnover intentions among academicians
Authors: Faisal Shaha , Naushad Mohammad
Published: November 2021

Employee turnover is a major concern for organizations. Specifically, among private business schools, it is proved to be one of the major impediments in carrying out academic activities. This phenomenon creates a conundrum for both college administrations and students. Therefore, each academic unit must work to minimize employee turnover. This study aims to identify the elements that influence academicians’ turnover intentions and the ways to negate them. It used a random sample of 236 academicians (professors, assistant professors, associate professors, and lecturers) from various business schools in India. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to analyze the sample. In addition, the structural equation modeling (SEM) approach was used to examine the hypotheses. All variables studied had high loadings of 0.50 or more in CFA. The research model was shown to be fit on three important absolute fit indices: absolute, incremental, and parsimonious. The regression weights of hypotheses were also determined to be significant. The findings indicate that organizational support, compensation, and personnel management had a detrimental effect on turnover intentions at business schools. These results can be used by college administration and management in devising interventions that will assist them in retaining existing talented staff and avoiding the negative repercussions of future turnover.
Gestão, história decolonial e literatura: Macunaíma como personagem antropofágico para (re)pensarmos a crítica nos Estudos Organizacionais
Authors: Silva Ítalo Da , Dias Pâmela Karolina , Dos Santos Elisabeth Cavalcante
Published: November 2021

Diante do contexto assimétrico de poder na produção de conhecimento e na perpetuação institucional da colonialidade na área dos Estudos Organizacionais (EOR), a nossa reflexão neste artigo apresenta duas contribuições gerais a partir da articulação entre os âmbitos da gestão, história e literatura. De início, perguntamos como poderíamos repensar a crítica nos Estudos Organizacionais (EOR) a partir do olhar histórico-decolonial frente à realidade da gestão local que constitui nossas demandas empíricas. Assim, resgatamos a obra literária “Macunaíma, o herói sem nenhum caráter”, escrito por Mário de Andrade, e o conceito de antropofagia, para propormos projetos epistemológicos críticos que compreendam o descompasso epistêmico entre o Norte e o Sul Global. Argumentamos que o constructo de gestão “às avessas e sem caráter” fornece um potencial teórico de interpretação da gestão praticada no Sul Global, a qual compreende elementos de não unicidade identitária, de um “entre lugar” moderno/colonial conflituoso e ambíguo, além de reverberar traços antropofágicos que demarcam a gestão tropical mediante à transculturação, flexibilidade, adaptabilidade e miscibilidade. Ao final, mostramos como nossas experiências anteriores com organizações das culturas populares nos possibilitou apresentar a ambivalência analítica e pluriversal da gestão local através de traços organizacionais derivados da ancestralidade, cotidiano, misticismos e transmissão de saberes pela oralidade.
Humor como estratégia discursiva: uma análise das charges do jornal sindical Folha Bancária
Authors: Monteiro Daniel Francisco Bastos , Correia Gabriel Farias Alves , Carrieri Alexandre De Pádua
Published: November 2021

O objetivo do artigo é analisar como o humor enquanto estratégia discursiva em charges é capaz de revelar as práticas do Sindicato dos Bancários de São Paulo. O trabalho se torna relevante a partir da possibilidade de evidenciar práticas de resistência, transgressão ou contradição em organizações por meio de charges veiculadas em seus canais oficiais de comunicação. Adotamos a metodologia qualitativa e analisamos, com base na analítica de poder foucaultiana, cinco charges publicadas no jornal sindical Folha Bancária, além de nove reportagens e documentos públicos disponíveis no sítio do sindicato e da Fundação Projeto Travessia. Os resultados sugerem contradições nas práticas do sindicato, revelando incoerências em parcerias com bancos privados, estratégias de sindicalização que enfraquecem as lutas coletivas e a ausência de resultados expressivos em seus canais de denúncias contra o assédio moral.
Literatura e estudos organizacionais em prosa, verso, drama e ficção
Authors: Ipiranga Ana Silvia Rocha , Saraiva Luiz Alex Silva
Published: November 2021

Neste texto os editores da edição especial “Verso, Prosa, Drama e Ficção: Literatura e Organizações” se propõem a fazer um breve percurso, levantando de forma não exaustiva a produção relacionada à provocativa intercessão entre Literatura e Estudos Organizacionais. A partir da problematização da arte, que se vê pressionada a lidar com a economia, a discussão evolui para cruzamentos entre estética e organizações, o que precede uma discussão especificamente dedicada à relação entre literatura e estudos organizacionais. Nesta seção a discussão gira em torno das questões da narrativa e da ficção, de diálogos possíveis a partir de charges, da poesia e do romance. Um breve mapeamento da produção nacional e estrangeira é feito e, na última seção, a edição especial é apresentada.
A QUÍMICA DE PRODUTOS NATURAIS APLICADOS A REVELADORES DE IMPRESSÕES DIGITAIS LATENTES
Authors: Leitzke Amanda , Berneira Lucas , Rosa Bruno , Moreira Bruna , Mariotti Kristiane , Venzke Dalila , Pereira Claudio
Published: November 2021

THE CHEMISTRY OF NATURAL PRODUCTS APPLIED TO LATENT FINGERMARK DEVELOPERS. Natural formulations have attracted great interest of many researchers regarding their use as latent fingermark developers powders due their important characteristics as the presence of natural pigments in these materials that offer a good contrast on the applied surface and also luminescent properties, which facilitates the visualization of minutiae in problematic substrates such as multicolored surfaces. In addition, natural powders present low toxicity, are widely available and economically viable. In this sense, the present work addresses the application of several natural products to enhance fingermarks visualization. The natural products were obtained from various sources such as seaweed, spices as well as other sources such as terrestrial and herbaceous plants. The evaluated powders are composed by compounds as chlorophyll, phycocyanins, curcumins, lawsone, fatty acids, coumarins, flavonoids and terpenes. These powders showed good adhesion to latent fingermarks, with similar or superior efficiency to the available powders on different surfaces with clear visualization of the minutiae. The development of new powders applicable to papiloscopy are extremely important since the conventional available powders, besides being expensive, are imported and within the national context there is a great lack of these revealing materials within forensic investigations by the Federal Police and in laboratories of research.
Implikasi Kepemimpinan Situasional pada Efektivitas Prestasi Kerja TU di Sekolah Menengah Pertama Negeri 23 Semarang
Authors: Chuluq Burhanuddin Chusnul , Khunaifi Agus , Pamungkas Fanzal
Published: November 2021

The leader is the person who is authorized to lead the activities in a group, the leadership role of the headmaster means a lot to the school, the success of the school is very closely related to the style and approach of the headmaster's leadership, how the headmaster manages his subordinates in order to produce the order as expected. This research is a field research with qualitative approach. The subjects of the study were the principal and administrative staff. Data obtained by interviews, observations and documentation.The results of this study concluded that there are implications of situational leadership of the principal on the effectiveness of administrative performance seen from the type of situational leadership, namely the first instruction process of the principal to the administrative admin coordinator, the second consultation process between the administration and the principal, resulting in a harmonious relationship and also intertwined two-way communication, the third process of participation when the principal is involved in the work that coincides with the administrative staff and the fourth process of delegation of the principal on administrative performance does not provide training directly to support the performance of the administration.
Manajemen Penjaminan Mutu Dalam Meningkatkan Kedisiplinan Siswa Di MA Raudlatul Ulum Guyangan Pati
Authors: Aizzatin Aizzatin , Uhbiyati Nur , Musthofa Musthofa
Published: November 2021

Improving student discipline is one way in quality assurance in Madrasah Aliyah Raudlatul Ulum Guyangan Pati. This study aims to : 1. Describe and analyze quality assurance planning in improving student discipline at MA Raudlatul Ulum Guyangan Pati 2. Describe and analyze the implementation of quality assurance in Madrasah Raudlatul Ulum Guyangan Pati 3. Describe and analyze the evaluation of quality assurance in Madrasah Aliyah Raudlatul Ulum Guyangan Pati.This research is qualitative research, which aims to understand a phenomenon that is happening observed by researchers. In the discussion of this thesis is used a method that is descriptive analysis that is the method aims to know how the Principal and his staff guarantee the quality of madrasah by improving the discipline of students in Madrasah Aliyah Raudlatul Ulum Guyangan Pati.In this research study that (1) Education quality assurance planning in improving discipline MA (2) Implementation of quality assurance discipline (3) Evaluation of quality assurance of education.From the results of the study, the author gave advice to educational institutions Raudlatul Ulum Guyangan Pati to maintain achievements that have not been achieved by madrasah, improve achievements that have not been achieved, cultivate a quality culture to advance madrasah, hold recruitment of teachers or educational personnel to succeed educational activities, and provide facilities or facilities and good learning infrastructure.