bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: 1,4‐Bis(arylsulfonyl)‐1,2,3,4‐tetrahydropyridines in Synthesis. Regio‐ and Stereoselective SN1 Reactions.
Authors: Adelbrecht Jean‐Claude , Craig Donald , Thorimbert Serge
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Synthesis of Tetrahydro‐2(1H)‐quinolones Using Diels—Alder Reactions of 1‐Arylsulfonyl‐2(1H)‐pyridones Having an Electron‐Withdrawing Group.
Authors: Fujita Reiko , Watanabe Kazuhiro , Ikeura Wakako , Ohtake Yohsuke , Hongo Hiroshi , Harigaya Yosihiro , Matsuzaki Hisao
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: HIV‐1 Replication Inhibitors of the Styrylquinoline Class: Incorporation of a Masked Diketo Acid Pharmacophore.
Authors: Zouhiri Fatima , Desmaele Didier , d'Angelo Jean , Ourevitch Michele , Mouscadet Jean‐Francois , Leh Herve , Le Bret Marc
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Addition of Nucleophiles to C‐1 Position of Isoquinolines Using (S)‐Alanine Derivatives as Chiral Auxiliaries.
Authors: Itoh Takashi , Nagata Kazuhiro , Miyazaki Michiko , Kameoka Keiko , Ohsawa Akio
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Addition of Grignard Reagents to New Lipophilic Isoquinolinium Salts Applied to the Synthesis of Stable Ethyl 1,2‐Disubstituted 1,2‐Dihydroisoquinoline‐3‐carboxylates and Derivatives.
Authors: Meziane Mohamed Ait Amer , Bazureau Jean Pierre
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Double Intramolecular Hetero Diels—Alder Reactions of α,β‐Unsaturated Hydrazones as 1‐Azadienes: A New Route to 2,2′‐Bipyridines.
Authors: Bushby Nicholas , Moody Christopher J. , Riddick David A. , Waldron Ian R.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design and Synthesis of Pfmrk Inhibitors as Potential Antimalarial Agents.
Authors: Xiao Zili , Waters Norman C. , Woodard Cassandra L. , Li Zhiyu , Li Pui‐Kai
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoselective Reduction of Pyrimidines. An Access to Enantiopure Tetrahydropyrimidinones.
Authors: Agami Claude , Dechoux Luc , Melaimi Mohand
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Vasorelaxant Potency of Monagra. A Chiral 5‐(2‐Methyl‐2,3‐dihydro‐7‐benzofuryl)pyrazolopyrimidone Analogue of Viagra®.
Authors: Al‐bojuk Nader R. , El‐Abadelah Mustafa M. , Sabri Salim S. , Michel Alain , Voelter Wolfgang , M.‐Moessmer Caecilia , Al‐Abed Yousef
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Synthesis of Novel 5‐Substituted‐2,3‐dihydroimidazo[1,2‐c]thieno[3,2‐e]pyrimidines.
Authors: Raghu Prasad Mailavaram , Rao Akkinepalli Raghu Ram , Shanthan Rao Pamulaparthi , Subramanian Rajan Kombu
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Methyl 2‐Arylethylcarbamates with Thionyl Chloride: Formation of Benzothiazine and Benzo[b]thiophene Ring Systems.
Authors: Mohri Kunihiko , Yoshida Yuki , Awano Takako , Takeuchi Yoshiaki , Isobe Kimiaki
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Control of Hydroboration of 1‐Alkynylphosphonates, Followed by Suzuki Coupling Provides Regio‐ and Stereospecific Synthesis of Disubstituted 1‐Alkenylphosphonates.
Authors: Pergament Inna , Srebnik Morris
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nucleophilic Addition of Organolithium Reagents to Cyanine Dyes. A New Access to Functionalized Hexatrienes.
Authors: Viteva Lilia , Gospodova Tzveta , Stefanovski Yuri , Mazieres Marie‐Rose , Wolf Jean Gerard
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A 3‐Hydroxychromone with Dramatically Improved Fluorescence Properties.
Authors: Klymchenko Andrey S. , Ozturk Turan , Pivovarenko Vasyl G. , Demchenko Alexander P.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 6,7‐Dehydroartemisinic Acid.
Authors: Sy Lai‐King , Brown Geoffrey D.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Noroleanane‐Type Triterpene Saponins (I)—(III) with Gastroprotective Effect and Platelet Aggregation Activity from the Flowers of Camellia japonica: Revised Structures of Camellenodiol and Camelledionol.
Authors: Yoshikawa Masayuki , Morikawa Toshio , Fujiwara Emi , Ohgushi Teruki , Asao Yasunobu , Matsuda Hisashi
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the CD Ring in Taxol from (S)‐(+)‐Carvone.
Authors: Shing Tony K. M. , Lee Chi M. , Lo Ho Y.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Peculiar Steroidal Saponins with Opened E‐Ring from Solanum genera Plants.
Authors: Zhu Xing‐Hua , Tsumagari Hidetsugu , Honbu Takehiko , Ikeda Tsuyoshi , Ono Masateru , Nohara Toshihiro
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 5‐Substituted Pyrido[2,3‐d]pyrimidines as Analogues of the Antifolates Methotrexate, DDATHF and Pemetrexed (LY231514).
Authors: Schoenfeld Franz , Troschuetz Reinhard
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Atom‐Economical Synthesis of the N(10)—C(17) Fragment of Cyclotheonamides via a Novel Passerini Reaction—Deprotection—Acyl Migration Strategy.
Authors: Owens Timothy D. , Semple J. Edward
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of β‐Lactams via Ring Opening of a Serine‐Derived Aziridine.
Authors: Turner John J. , Sikkema Frisco D. , Filippov Dmitri V. , van der Marel Gijs A. , van Boom Jacques H.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Transformations of New Annulated Pyranosides Using the Pauson—Khand Reaction.
Authors: Marco‐Contelles Jose , Ruiz‐Caro Juliana
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 3‐Hexuloses from 1,2:5,6‐Di‐O‐isopropylidenehexitols.
Authors: Ekeberg Dag , Morgenlie Svein , Sternstroem Yngve
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conformational Analysis of Sugar—Peptide Adducts (I)‐(III) in the Solution State by NMR Spectroscopy and Molecular Modeling.
Authors: Jeric Ivanka , Novak Predrag , Vinkovic Mladen , Horvat Stefica
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Wittig Reaction with 2‐Deoxysugars: The Role of Triphenyl‐ and Trialkyltin Halides.
Authors: Costantino Valeria , Imperatore Concetta , Fattorusso Ernesto , Mangoni Alfons
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Bis‐Dansyl‐Modified β‐Cyclodextrin Liner Trimer Having Multi‐recognition Sites and High Hydrophobic Environment.
Authors: Kikuchi Tohru , Narita Miyuki , Hamada Fumio
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Mannosidase Inhibitory Activity of 3‐Benzyloxymethyl Analogues of Swainsonine.
Authors: Pearson William H. , Guo Luyi
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Mannosidase Inhibitory Activity of 6‐ and 7‐Substituted Analogues of Swainsonine.
Authors: Pearson William H. , Hembre Erik J.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mono‐6‐(O‐2,4‐6‐triisopropylbenzenesulfonyl)‐γ‐cyclodextrin, a Novel Intermediate for the Synthesis of Mono‐Functionalized γ‐Cyclodextrins.
Authors: Palin Ronald , Grove Simon J. A. , Prosser Alan B. , Zhang Ming‐Qiang
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Conformational Analysis of the T‐Antigen Disaccharide (β‐D‐Gal‐(1→3)‐α‐D‐GalNAc‐OMe).
Authors: Bukowski Ralph , Morris Laura M. , Woods Robert J. , Weimar Thomas
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Epibatidine Isomers: endo‐5‐ and 6‐(6′‐Chloro‐3′‐pyridyl)‐2‐azabicyclo[2.2.1]heptanes.
Authors: Cox Caroline D. , Malpass John R. , Gordon John , Rosen Alan
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Cocculolidine.
Authors: Kawasaki Tsuneomi , Onoda Naoko , Watanabe Hidenori , Kitahara Takeshi
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the Grass Alkaloid Perlolidine Through a Pyridyne Cyclization Reaction.
Authors: Kessar S. V. , Singh Paramjit
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structure Determination of Some Oxadiazole‐2‐thione and Triazole‐3‐thione Galactosides.
Authors: Ahmad Roshan , Iqbal Rashid , Akhtar Humaira , Zia‐ul‐Haq Zia‐ul‐Haq , Duddeck Helmut , Stefaniak Lech , Sitkowski Jerzy
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Certain 2′‐Deoxyuridine Derivatives Containing Substituted Phenoxy Groups Attached to C‐5′; Evaluation as Potential dUTP Analogues.
Authors: Marriott Jonathan H. , Aherne G. Wynne , Hardcastle Anthea , Jarman Michael
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Selenium‐Derivatized Nucleosides and Oligonucleotides for X‐Ray Crystallography.
Authors: Carrasco Nicolas , Ginsburg Dov , Du Quan , Huang Zhen
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: X‐Ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol‐O‐methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity.
Authors: Lerner Christian , Ruf Armin , Gramlich Volker , Masjost Birgit , Zuercher Gerhard , Jakob‐Roetne Roland , Borroni Edilio , Diederich Francois
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: TT Dinucleotides Containing an Isoxazoline Moiety: Synthesis and Binding Affinity Study.
Authors: Kong Jong Rock , Kim Sang Kook , Moon Byung Jo , Kim Su Jeong , Kim Byeang Hyean
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antiviral Evaluation of N‐Glycosides Derived from 6‐Amino‐3‐aryl‐2‐methyl‐4‐(3H)‐quinazolinones.
Authors: Saleh Mohamed A. , Abbas Youssef A. , Eabdel‐Hai Fouad , Youssef Shaban A.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Flavonoid from Mentha longifolia
Authors: Jahan Nusrat , Malik Abdul , Muhammad Pir
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Naturally Occurring Cinnamyl Cinnamates.
Authors: Mali Raghao S. , Papalkar Abhijit S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Designed Antagonist of the Thyroid Hormone Receptor.
Authors: Yoshihara Hikari A. I. , Apriletti James W. , Baxter John D. , Scanlan Thomas S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: iPF2α‐III Metabolism. First Total Synthesis of 2,3‐Dinor iPF2α‐III, a Primary β‐Oxidation Metabolite.
Authors: Kim Seongjin , Jung Young‐Ju , Lawson John A. , FitzGerald Garret A. , Rokach Joshua
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Syntheses of Epothilones B and D: Applications of Allylstannanes in Organic Synthesis.
Authors: Martin Nathaniel , Thomas Eric J.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of (3R,5R)‐cis‐3‐Hydroxy‐5‐phenylpyrrolidine.
Authors: Maeda Kenji , Yamamoto Yuhei , Tomimoto Koji , Mase Toshiaki
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Salvianolic Acid L, a Potent Phenolic Antioxidant from Salvia officinalis.
Authors: Lu Yinrong , Foo L. Yeap
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pyrimidinylimidazole Inhibitors of p38: Cyclic N‐1 Imidazole Substituents Enhance p38 Kinase Inhibition and Oral Activity.
Authors: Adams Jerry L , et al. et al.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Discovery of Anthranilic Acid‐Based MMP Inhibitors. Part 3. Incorporation of Basic Amines.
Authors: Levin J. I. , et al. et al.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fipronil‐Based Photoaffinity Probe for Drosophila and Human β3 GABA Receptors.
Authors: Sirisoma Nilantha S. , Ratra Gurpreet S. , Tomizawa Motohiro , Casida John E.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoluminescence Characteristics of Spherical Y2O3:Eu Phosphors by Aerosol Pyrolysis.
Authors: Hong Gun Young , Jeon Byung Soo , Yoo Joung Kil , Yoo Jae Soo
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Research in Nanosciences — Great Opportunity for Catalysis Science.
Authors: Somorjai G. A. , Borodko Y. G.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Imido Analogues of Common Oxo Anions: A New Episode in the Chemistry of Cluster Compounds
Authors: Brask Justin K. , Chivers Tristram
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Semibullvalenes and Related Molecules: Ever Closer Approaches to Neutral Homoaromaticity
Authors: Williams Richard Vaughan
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polymeric Scavenger Reagents in Organic Synthesis
Authors: Eames Jason , Watkinson Michael
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dual‐Acting Drugs: an in vitro Study of Nonimidazole Histamine H3 Receptor Antagonists Combining Anticholinesterase Activity
Authors: Incerti Matteo , Flammini Lisa , Saccani Francesca , Morini Giovanni , Comini Mara , Coruzzi Massimo , Barocelli Elisabetta , Ballabeni Vigilio , Bertoni Simona
Published: May 2010

Dual‐acting compounds that combine H3 antagonism with anticholinesterase properties are currently emerging as a novel and promising therapeutic approach in the treatment of multifactorial disorders primarily characterized by cholinergic deficits such as Alzheimer's disease. A series of novel nonimidazole H3 ligands was developed from the chemical manipulation of 1,1′‐octa‐, ‐nona‐, and ‐decamethylene‐bis‐piperidines—H3 antagonists that had been the subject of previous investigations. These compounds were evaluated for in vitro binding affinity, antagonistic potency, and selectivity at rodent and human histamine H3 receptors, inhibitory activity at rat brain cholinesterase, and in vivo CNS access and cholinomimetic effects. Within the present series, the tetrahydroaminoacridine hybrid 18 stands out as one of the most attractive molecules, synergistically combining nanomolar and selective H3 antagonism with remarkable anticholinesterase activity. From this original starting point, it is hoped that future investigations will lead to dual‐acting compounds that can selectively enhance central cholinergic neurotransmission and thus facilitate the treatment of cognitive disorders.
Multimodality imaging techniques
Authors: Martí‐Bonmatí Luis , Sopena Ramón , Bartumeus Paula , Sopena Pablo
Published: May 2010

In multimodality imaging, the need to combine morphofunctional information can be approached by either acquiring images at different times (asynchronous), and fused them through digital image manipulation techniques or simultaneously acquiring images (synchronous) and merging them automatically. The asynchronous post‐processing solution presents various constraints, mainly conditioned by the different positioning of the patient in the two scans acquired at different times in separated machines. The best solution to achieve consistency in time and space is obtained by the synchronous image acquisition. There are many multimodal technologies in molecular imaging. In this review we will focus on those multimodality image techniques more commonly used in the field of diagnostic imaging (SPECT‐CT, PET‐CT) and new developments (as PET‐MR). The technological innovations and development of new tracers and smart probes are the main key points that will condition multimodality image and diagnostic imaging professionals' future. Although SPECT‐CT and PET‐CT are standard in most clinical scenarios, MR imaging has some advantages, providing excellent soft‐tissue contrast and multidimensional functional, structural and morphological information. The next frontier is to develop efficient detectors and electronics systems capable of detecting two modality signals at the same time. Not only PET‐MR but also MR‐US or optic‐PET will be introduced in clinical scenarios. Even more, MR diffusion‐weighted, pharmacokinetic imaging, spectroscopy or functional BOLD imaging will merge with PET tracers to further increase molecular imaging as a relevant medical discipline. Multimodality imaging techniques will play a leading role in relevant clinical applications. The development of new diagnostic imaging research areas, mainly in the field of oncology, cardiology and neuropsychiatry, will impact the way medicine is performed today. Both clinical and experimental multimodality studies, in humans and animals, will have to demonstrate an efficient use of the imaging information provided by the modalities to affect the future of medical imaging. Copyright © 2010 John Wiley & Sons, Ltd.
Pathologic complete response in breast cancer patients receiving anthracycline‐ and taxane‐based neoadjuvant chemotherapy
Authors: Chavez‐MacGregor Mariana , Litton Jennifer , Chen Huiqin , Giordano Sharon H. , Hudis Clifford A. , Wolff Antonio C. , Valero Vicente , Hortobagyi Gabriel N. , Bondy Melissa L. , Gonzalez‐Angulo Ana Maria
Published: May 2010

BACKGROUND:

The current study was conducted to evaluate the influence of race/ethnicity and tumor subtype in pathologic complete response (pCR) following treatment with neoadjuvant chemotherapy.

METHODS:

A total of 2074 patients diagnosed with breast cancer between 1994 and 2008 who were treated with neoadjuvant anthracycline‐ and taxane‐based chemotherapy were included. pCR was defined as no residual invasive cancer in the breast and axilla. The Kaplan‐Meier product‐limit was used to calculate survival outcomes. Cox proportional hazards models were fitted to determine the relationship of patient and tumor variables with outcome.

RESULTS:

The median patient age was 50 years; 14.6% of patients were black, were 15.2% Hispanic, 64.3% were white, and 5.9% were of other race. There were no differences in pCR rates among race/ethnicity (12.3% in black, 14.2% in Hispanics, 12.3% in whites, and 11.5% in others, P = .788). Lack of pCR, breast cancer subtype, grade 3 tumors, and lymphovascular invasion were associated with worse recurrence‐free survival (RFS) and overall survival (OS) (P ≤ .0001). Differences in RFS by race/ethnicity were noted in the patients with hormone receptor‐positive disease (P = .007). On multivariate analysis, Hispanics had improved RFS (hazard ratio [HR], 0.69; 95% confidence interval [95% CI], 0.49‐0.97) and OS (HR, 0.63; 95% CI, 0.41‐0.97); blacks had a trend toward worse outcomes (RFS: HR, 1.28 [95% CI, 0.97‐1.68] and OS: HR, 1.32 [95% CI, 0.97‐1.81]) when compared with whites.

CONCLUSIONS:

In this cohort of patients, race/ethnicity was not found to be significantly associated with pCR rates. On a multivariate analysis, improved outcomes were observed in Hispanics and a trend toward worse outcomes in black patients, when compared with white patients. Further research was needed to explore the potential differences in biology and outcomes. Cancer 2010. © 2010 American Cancer Society.
Bevacizumab and everolimus in the treatment of patients with metastatic melanoma
Authors: Hainsworth John D. , Infante Jeffrey R. , Spigel David R. , Peyton James D. , Thompson Dana S. , Lane Cassie M. , Clark Bobby L. , Rubin Mark S. , Trent David F. , Burris Howard A.
Published: May 2010

BACKGROUND:

In this phase 2 study, the activity and tolerability of the combination of bevacizumab, an inhibitor of angiogenesis, and everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), was evaluated in the treatment of patients with metastatic melanoma.

METHODS:

Patients with metastatic melanoma who had received up to 2 previous systemic regimens (chemotherapy and/or immunotherapy) were eligible. Previous treatment with angiogenesis or mTOR inhibitors was not allowed. All patients received bevacizumab at a dose of 15 mg/kg intravenously every 21 days and everolimus at a dose of 10 mg orally daily. Patients were re‐evaluated every 6 weeks; those with an objective response or stable disease (according to Response Evaluation Criteria in Solid Tumors [RECIST]) continued therapy until tumor progression or unacceptable toxicity occurred.

RESULTS:

Fifty‐seven patients with metastatic melanoma received a median of 4 treatment cycles (range, 1‐14+ cycles). Seven patients (12%) achieved major responses, whereas 33 patients (58%) were found to have stable disease at the time of first evaluation. The median progression‐free and overall survivals were 4 months and 8.6 months, respectively. Approximately 43% of patients were alive after 12 months of follow‐up. The treatment regimen was well tolerated by the majority of patients.

CONCLUSIONS:

The combination of bevacizumab and everolimus was found to have moderate activity and was well tolerated in the treatment of patients with metastatic melanoma. Further exploration of agents with these mechanisms of action is indicated, perhaps in combination with inhibitors of the mitogen‐activated protein kinase (MAPK) pathway. Cancer 2010. © 2010 American Cancer Society.
Paired box gene 8, HBME‐1, and cytokeratin 19 expression in preoperative fine‐needle aspiration of papillary thyroid carcinoma
Authors: Schmitt Alessandra C. , Cohen Cynthia , Siddiqui Momin T.
Published: May 2010

BACKGROUND:

Paired box gene 8 (PAX8), a member of the thyroid‐specific transcription factors, has recently been investigated as a useful marker of thyroid epithelial neoplasms. To the authors' knowledge, its utility in the immunohistochemistry of papillary thyroid carcinoma (PTC) has not been well studied to date. The goal of the current study was to compare the immunohistochemical expression of PAX8 with HBME‐1 and cytokeratin 19 (CK19) expression on cell block preparations of PTC and benign thyroid nodules (BTN).

METHODS:

Thirty‐two cases of PTC and 20 cases of BTN diagnosed on fine‐needle aspiration were included. The cell blocks were immunohistochemically stained for PAX8, HBME‐1, and CK19.

RESULTS:

PAX8 demonstrated nuclear positivity in >90% of cases with PTC (31 of 32 cases; 96.9%) and BTN (20 of 20 cases; 100%), with a high sensitivity (0.97), but low specificity (0). HBME‐1 and CK19 were found to have high sensitivity (0.78 and 0.75, respectively) and specificity (0.95 for both) for PTC. Statistically significant differences in staining intensity and distribution were noted for the PAX8 antibody (negative [1 of 32 cases] to weakly positive [20 of 32 cases] in 65.6% of PAX8‐positive PTCs, and intermediate to strong in 100% of BTNs).

CONCLUSIONS:

In contrast to PAX8, HBME‐1 and CK19 were found to have a high degree of both sensitivity and specificity for PTC. The results of the current study demonstrate that strong PAX8 staining appears to be typical of BTNs, whereas negative to weakly positive staining is noted in PTC. PAX8, HMBE‐1 and CK19 may all play a role, particularly as a panel; however, the interpretation of PAX8 should consider the intensity and distribution of staining. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.
Laser‐induced damage of DKDP crystal under different wavelengths
Authors: Xu Mingxia , Sun Xun , Wang Zhengping , Cheng Xiufeng , Sun Shaotao , Ji Lailin , Zhao Yuanan , Liu Baoan , Gao Hui , Xu Xinguang
Published: May 2010

In this paper, DKDP crystals were grown from 80% deuterated solution by traditional temperature‐reduction method. The crystal samples were selected to test laser damage threshold (LDT) and laser conditioning of 1ω, 2ω and 3ω. We found that the laser conditioning of 3ω has much more effect on improving the LDT. The damage site was observed by microscope and its effects on micro‐structure and optical properties were also studied. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effect of annealing and composition on crystal structure, surface morphology and optical absorption of chemically deposited Cd1‐xSnxS films
Authors: Das R. , Kumar R.
Published: May 2010

Cd1‐xSnxS thin films were successfully deposited on suitably cleaned glass substrate by chemical bath deposition method at 74 °C. Hydrated Stannous Chloride (SnCl2.2H2O) in aqueous solution was added to the CdS growing solution in different proportions. The experimental results indicate, a successful doping for lower concentration of Sn, saturation for intermediate doping levels, and a degradation of the doping process for higher concentration of Sn. Indirect (X‐ray diffraction) and Direct (Scanning electron microscopy) measurements were performed to characterize the growth and the nature of crystallinity of the different Cd1‐xSnxS films. The effect of annealing on the crystal structure and morphology of the deposited films has also been discussed. The X‐ray diffraction spectra show that the thin films are polycrystalline and have both cubic and hexagonal structure. The Interplanar spacing, lattice constant, grain size, strain, and dislocation density were calculated for as‐deposited and annealed films. The grain size was found to decrease from 5 nm to 0.89 nm with doping concentration of Sn. The grain size further decreased due to annealing at 400 °C. SEM studies show layered growth and long needle like structures along with some voids. After annealing the densification and smaller size of the particles was also observed. The optical absorption spectra show shifting of absorption peaks towards lower wavelength side (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2
Authors: Michell Anna C. , Bragança José , Broadbent Carol , Joyce Bradley , Franklyn Angela , Schneider Jürgen E. , Bhattacharya Shoumo , Bamforth Simon D.
Published: May 2010

Deletion of the transcriptional modulator Cited2 in the mouse results in embryonic lethality, cardiovascular malformations, adrenal agenesis, cranial ganglia fusion, exencephaly, and left–right patterning defects, all seen with a varying degree of penetrance. The phenotypic heterogeneity, observed on different genetic backgrounds, indicates the existence of both genetic and environmental modifiers. Mice lacking the LIM domain‐containing protein Lmo4 share specific phenotypes with Cited2 null embryos, such as embryonic lethality, cranial ganglia fusion, and exencephaly. These shared phenotypes suggested that Lmo4 may be a potential genetic modifier of the Cited2 phenotype. Examination of Lmo4‐deficient embryos revealed partially penetrant cardiovascular malformations and hypoplastic thymus. Examination of Lmo4;Cited2 compound mutants indicated that there is a genetic interaction between Cited2 and Lmo4 in control of thymus development. Our data suggest that this may occur, in part, through control of expression of a common target gene, Tbx1, which is necessary for normal thymus development. Developmental Dynamics 239:1988–1994, 2010. © 2010 Wiley‐Liss, Inc.
Occurrence of synthetic musk fragrances in human blood from 11 cities in China
Authors: Hu Zhengjun , Shi Yali , Niu Hongyun , Cai Yaqi , Jiang Guibin , Wu Yongning
Published: May 2010

We measured two nitro musk fragrances (musk xylene) and musk ketone) and five polycyclic musk fragrances (galaxolide [HHCB], tonalide [AHTN], celestolide [ADBI], traseolide [ATII], and phantolide [AHMI]) in human blood samples from 11 cities of China (n = 204). Possible temporal trends in musk concentrations and associations with personal factors, such as gender, age, and others, were studied. Galaxolide (HHCB) showed the highest median concentration (0.85 ng/g) followed by AHTN (0.53 ng/g) with high detection frequency (91 and 77%, respectively). Concentrations of the other synthetic musk fragrances, including musk ketone and musk xylene, were all below the quantification limits. The results suggested that musk concentrations were not significantly relative to gender and body weight but positively correlated with age groups and locations. Apparent differences were also observed in the ratios of HHCB to AHTN concentrations among different cities. Environ. Toxicol. Chem. 2010;29:1877–1882. © 2010 SETAC
High sensitivity of cyanobacterium Microcystis aeruginosa to copper and the prediction of copper toxicity
Authors: Zeng Jin , Yang Liuyan , Wang Wen-Xiong
Published: May 2010

Microcystis aeruginosa is a dominant cyanobacterium commonly found in Chinese freshwater ecosystems during phytoplankton blooms, and copper sulfate is one of the most frequently used algicides for controlling the nuisance blooms. In this study, we examined the effects of varied water chemistry (dissolved organic matter, pH, and hardness) on copper (Cu) toxicity to M. aeruginosa, as well as the Cu short-term uptake kinetics, using 67Cu as a radioactive tracer. Elevated dissolved organic matter concentrations resulted in a reduction of Cu toxicity, and increasing pH in the range 6.7 to 8.5 led to an increase of Cu toxicity based on the ambient dissolved Cu concentration. The variation of growth inhibition was much more dependent on the intracellular Cu concentration than on the total ambient Cu or calculated free Cu2+ concentration; thus, the biotic ligand model could be used to explain the Cu toxicity to M. aeruginosa under different water chemistry conditions. We demonstrated that M. aeruginosa were extremely sensitive to Cu toxicity compared with other freshwater phytoplankton species based on the intracellular Cu concentration. The median inhibition concentration of intracellular Cu was as low as 3.3 to 13.1 × 10−18 mol Cu/cell for all treatments. The Cu short-term uptake kinetics in M. aeruginosa could be explained by the free-ion activity model. The uptake rate, however, could not explain the discrepancy in Cu sensitivity between M. aeruginosa and other phytoplankton species. Other mechanisms might explain the extreme sensitivity of M. aeruginosa to Cu toxicity. Environ. Toxicol. Chem. 2010;29:2260–2268. © 2010 SETAC
Mercury and halogenated organic contaminants in river otters (Lontra canadensis) in New Jersey, USA
Authors: Stansley William , Velinsky David , Thomas Roger
Published: May 2010

Liver samples collected from New Jersey river otters (Lontra canadensis) in 2005 and 2007 were tested for Hg, organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polybrominated diphenyl ethers (PBDEs). The highest mercury concentrations were found in otters living in the Pinelands region, where acidic soils and surface waters enhance Hg bioavailability. The highest individual Hg concentration was 19.8 µg/g wet weight, approximately 60% of the experimentally determined lethal threshold. Concentrations of OC pesticides were generally similar to those in otters from areas of Oregon and Washington close to agricultural and industrial sources. The geometric mean total PCB concentration (540 ng/g wet wt) was similar to the concentration in otters from the heavily populated and industrialized lower Columbia River in Oregon and Washington. Seven liver samples that were among the highest in terms of total PCBs were analyzed for PCDDs and PCDFs. Polychlorinated dibenzo-p-dioxins were detected in six of the samples at total concentrations ranging from 172 to 2,783 pg/g wet weight. Polychlorinated dibenzofurans were detected in three of the samples at total concentrations ranging from 1.50 to 2,719 pg/g wet weight. The geometric mean PBDE concentration was 10.6 ng/g wet weight, with a range of 0.82 to 436 ng/g wet weight. No statistically significant relationship was observed between liver contaminant concentrations and land use within an 8-km radius of the trapping location. Overall, the data suggest that contaminant concentrations are not high enough to adversely affect the overall otter population in New Jersey. However, contaminant-related effects on the health or reproductive success of individual otters in some areas are possible. Environ. Toxicol. Chem. 2010;29:2235–2242. © 2010 SETAC