bluuebunny/crossref_metadata_2025 huggingface dataset:
El spinozismo secreto de Lessing
Authors: Solé María Jimena
Published: July 2014

Desde que Jacobi comunicó a Mendelssohn de 1783, que Lessing le habría confesado su total acuerdo con el spinozismo, se discute hasta qué punto puede darse crédito a esta afirmación. En este artículo, nos proponemos rastrear las huellas de la posible influencia de Spinoza en el pensamiento de Lessing. A partir del análisis de diferentes textos -el fragmento titulado El cristianismo de la razón (1753), dos fragmentos de 1763 dirigidos a Mendelssohn y su última obra publicada en vida, La educación del género humano (1780)- sostenemos que se comprueba una clara afinidad entre algunas de sus posiciones metafísicas, éticas y políticas. En efecto, ambos adoptan un panteísmo metafísico que implica la inmanencia de la divinidad en el universo y que garantiza la posibilidad de un acceso racional a las verdades universales. Además, concuerdan en su concepción del ideal al que tiende el género humano, en que coinciden la sabiduría teórica, la perfección moral y la máxima felicidad. Si bien estas coincidencias no son suficientes para afirmar categóricamente una influencia directa y consciente de Spinoza en Lessing, sí permiten concluir que existen elementos doctrinales que respaldan la afirmación de que, en cierta medida, Lessing fue un spinozista.Ever since Jacobi told Mendelssohn in 1783 that Lessing had admitted his full agreement with Spinozism, the issue of how far this statement should be believed has been discussed. In this article, I propose to follow the tracks of Spinoza’s possible influence on Lessing’s thinking. Based on the analysis of different texts —the fragment titled Christianity of Reason (1753), two fragments from 1763 written to Mendelssohn, and the last work published during his lifetime, The Education of the Human Race (1780)- we hold that there is a clear affinity between some of their metaphysical, ethical, and political positions. In effect, both Lessing and Spinoza adopt a metaphysical pantheism that involves the immanence of divinity in the universe and that guarantees the possibility of rational access to universal truths. In addition, they coincide in their conception of the ideal toward which the human races tends, an ideal which includes theoretical wisdom, moral perfection, and maximum happiness. Although these coincidences are not sufficient to categorically state a direct and conscious influence of Spinoza on Lessing, they do allow us to conclude that there are doctrinal elements that back up, to a certain extent, the statement that Lessing was a Spinozist.
Valor e limites da causalidade em Schlick : sentido e aplicações
Authors: Meneses Ramiro Délio Borges de
Published: July 2014

Com a física moderna, particularmente pela criação da Mecânica Quântica, M. Schlick apresentou uma nova crítica, no âmbito do neopositivismo, sobre o princípio de causalidade.With modern physics and especially with the creation of quantum mechanics, M. Schlick presents a new criticism of the principle of causality in the sphere of neopositivism.
RESEÑA de : Torralba, José M. Libertad, objeto práctico y acción : la facultad del juicio en la filosofía moral de Kant. Hildesheim; Zürich; New York : Georg Olms Verlag, 2009
Authors: Cubo Ugarte Óscar
Published: July 2014

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La doctrina de la voluntariedad en la ética eudemia
Authors: Zanatta Marcelo
Published: July 2014

El análisis comparativo de la teoría aristotélica de la voluntariedad muestra que la Ética a Eudemo resume las tesis de la Ética a Nicomaco y las expone de una manera más rigurosa. Así, en este sentido, podríamos considerar que la Ética a Eudemo es posterior a la Ética a Nicómaco.
El racionalismo musulmán en la Edad Media
Authors: Manzanera Salavert Miguel
Published: July 2014

De Avicena es seguramente la expresión más madura del pensamiento racionalista musulmán de la Edad Media Este artículo investiga, desde una perspectiva marxista, cómo se hizo posible ese modo de pensar, cuáles fueron sus raíces históricas y qué organización económica, política y social justificó su aparición. Intenta averiguar también a qué problemas teóricos responde y qué necesidades intelectuales busca resolver. Finalmente esboza una breve exposición de su significado histórico y sus proyecciones hacia el futuro, hoy pasado nuestro.
¿Fue Pedro Abelardo un externista moral?
Authors: Mata García Gonzalo
Published: July 2014

En este artículo se pretende analizar, de modo sistemático, la cuestión acerca del posible externismo de Pedro Abelardo. Se pone de relieve la filosofía moral del filósofo del siglo XII desde la perspectiva actual de la metaética, así como la cuestión de las razones para actuar y la motivación moral que podemos extrapolar a la actualidad.
La problemática del deseo y su liberación en el pensamiento de Krishnamurti
Authors: Suances Marcos Manuel
Published: July 2014

Krishnamurti aborda la problemática complejidad del deseo mostrando simultáneamente su fuerza y contradicción. Sin juzgarlo, explica cómo el deseo es el motor de la vida que no puede reprimirse. Vivir sin deseos es carecer de vida, sensibilidad y belleza. Cuando el deseo es comprendido así, entonces se convierte en una gran pasión para vivir y en fuente de energía. Todos estos aspectos son analizados en este artículo.
Tiempo, espacio y minoría : entre los pensamientos de G. Deleuze yJ. Ortega y Gasset
Authors: Núñez García Amanda
Published: July 2014

El presente artículo propone, a pesar de las diferencias palpables que hay entre G. Deleuze y J. Ortega y Gasset, articular el pensamiento de ambos filósofos en orden a poder analizar nuestro presente y construir alternativas de futuro, elaborando una filosofía concreta y apegada a nuestras circunstancias. Ello es posible gracias a que encontramos en ambos pensadores un impulso y una dirección comunes comprensibles a través de la perspectiva de una ontología estética y política que iremos desarrollando a través de las nociones de tiempo, espacio, minoría y articulación de las diferencias.This paper intends to articulate the thinking of G. Deleuze and J. Ortega y Gasset, despite the palpable differences between them, in order to be able to analyze our present and build alternatives for the future, developing a concrete philosophy that is attached to our circumstances. This relationship is possible because both thinkers share a common direction and impulse that can be understood using the perspective of an aesthetic and political ontology that we will develop through the notions of time, space, minority and the articulation of differences.
Dé(cons)truire le sujet pour engendrer la pensée : ce que philosopherveut dire selon G. Deleuze
Authors: Canavera Julien
Published: July 2014

Pour Gilles Deleuze, tout acte effectif de pensée implique nécessairement un mouvement forcé de dépersonnalisation, de sorte que l’on ne pense qu’autrement, qu’en devenant autre. En ce sens, penser se fait toujours aux dépens de cette «belle intériorité » qu’est le sujet actif et connaissant, tout en commandant, plus profondément, une critique radicale de l’Image dogmatique qui lui sert d’appui et de justification. Le propos de cet article est donc de montrer quelles sont les implications qui découlent de la critique deleuzienne, à savoir: une nouvelle relation au temps, au corps, et en somme, à «ce que penser veut dire».For Gilles Deleuze, effective thinking necessarily implies a forced movement of depersonalization; therefore we only think by becoming somebody else. In this sense, thinking is always done at the expense of this «beautiful interiority» which is the active, knowing subject. At the same time, in a deeper sense, this requires a radical criticism of the dogmatic image that supports and justifies it (the active subject). The aim of this article is to show the implications of the Deleuzian critique, namely: a new relation to the time, the body and, in short, the «meaning of thinking.»
Complexiones : sobre "cómo" hacer filosofía con palabras
Authors: Rodríguez Gómez Federico
Published: July 2014

Este texto es una lectura crítica de la obra de Jesús Navarro Cómo hacer filosofía con palabras. A propósito del desencuentro entre Searle y Derrida (Madrid, FCE, 2010). Tras analizar las articulaciones e ideas del mismo, pasaremos a desarrollar algunas de sus complicaciones más interesantes.This paper is a critical reading of Jesus Navarro’s book How to do Philosophy with Words. Reflections on the Searle-Derrida Debate (Madrid, FCE, 2010). First, we will analyze the divisions and concepts of this book. Secondly, we will develop some of its most interesting complications.
RESEÑA de : Fernández Liria; Alegre Zahonero. El orden de El Capital. Madrid : Akal, 2010
Authors: Cubo Ugarte Óscar
Published: July 2014

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RESEÑA de : Rodríguez Marciel, Cristina. Nancytropías : topografías de una filosofía por venir en Jean-Luc Nancy. Madrid : Dykinson, 2011
Authors: Massó Castilla Jordi
Published: July 2014

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RESEÑA de : Habermas, J.; Taylor Ch.; Butler, J.; West, C. El poder de la religión en la esfera pública. Madrid : Trotta, 2011
Authors: Rodríguez García Sonia E.
Published: July 2014

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RESEÑA de : Múñoz-Alonso, Gemma. Estructura, metodología y escritura del Trabajo de Fin de Máster. Madrid : Escolar y Mayo Editores, 2011
Authors: Casado José Manuel
Published: July 2014

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El concepto de exposición simbólica en Kant
Authors: Mumbru Mora Alex
Published: July 2014

en el dominio teórico, la validez objetiva de nuestros conceptos depende de su posible referencia a la intuición, ya sea por medio de la mostración de un ejemplo del mismo o de su construcción en la intuición a priori. la exigencia de una referencia intuitiva se extiende también a aquellas representaciones que escapan por principio a toda posible sensibilización, si bien sin pretensión cognoscitiva alguna. este sería el caso de los conceptos de razón en general, de los que hace uso el discurso moral en cuanto esencialmente heterogéneo de nuestros conceptos teóricos. en el presente artículo se analiza la naturaleza, funcionamiento y lugar sistemático del concepto de «exposición simbólica », en cuanto modo alternativo de referencia al mundo sensible por el que se nos hacen patentes aspectos de una representación que carece de todo referente intuitivo directo, i.e. las ideas o conceptos de razón. en este sentido, se muestra el conjunto de relaciones por las que el ámbito estético deviene el campo de sensibilización del dominio moral.
Goethe, Schleirmacher y la valoración del Ion
Authors: Aguirre Javier
Published: July 2014

Los despectivos comentarios de Goethe y Schleiermacher sobre el Ion provocaron las dudas de los platonistas alemanes del siglo XIX acerca de la autoría platónica del diálogo. Asimismo, salvo contadas excepciones, durante ese siglo y parte del siglo XX la valoración del mismo fue escasa. El artículo intenta mostrar que, en lo relativo a su autoría, no hay serias razones para pensar que no se trate de una obra genuina de Platón; y en lo relativo a su valor filosófico, que el Ion representa un paso fundamental en el proyecto platónico de suplantar el papel de la poesía en el monopolio educativo de la polis.
Lecciones sobre Merleau-Ponty : un Merleau-Ponty renacido. RESEÑA de : Álvarez Falcón, Luis (coord.). La sombra de lo invisible : Merleau-Ponty 1961-2011 (Siete lecciones). Madrid : Eutelequia, 2011
Authors: Trilles Calvo Karina P.
Published: July 2014

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H. MacColl, C. S. Peirce y la lógica proposicional en el s. XIX
Authors: Castrillo Criado Pilar
Published: July 2014

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Propiedades teleológicas y supervivencia
Authors: Pérez Otero Manuel
Published: July 2014

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A propósito de Génesis y estructura y la fenomenología de Derrida
Authors: Castroviejo Raúl , Díaz Álvarez Jesús Miguel
Published: July 2014

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RESEÑA de : Blazquez, J.M.; Martínez-Pinna, J.; Montero, S. Historia de las religiones antiguas : Oriente, Grecia y Roma. Madrid : Cátedra, 1993
Authors: Martínez Francisco José
Published: July 2014

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RESEÑA de : González García, Moisés. Filosofía y cultura. Madrid : Siglo XXI, 1992
Authors: Díaz Alvarez J. Miguel
Published: July 2014

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¿Cómo ha de iniciarse la doctrina de la ciencia?: introducciones a la WLNM
Authors: Turró Salvi
Published: July 2014

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Sentimiento de sí y génesis de la objetividad: el tránsito del sentimiento a la intuición en los apartados § 6 (final) y § 7 de la Doctrina de la ciencia "nova methodo"
Authors: Coletas Caubet Ramón
Published: July 2014

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Lo inteligible y lo sensible: consideraciones sobre el § 13 de la Doctrina de la Ciencia nova methodo
Authors: Gaudio Mariano
Published: July 2014

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Doctrina de la Ciencia nova methodo: análisis del § 17 (primera parte)
Authors: Morujâo Carlos
Published: July 2014

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La autodeterminación del Yo-individuo y sus dos series en el § 17
Authors: Rivera de Rosales Jacinto
Published: July 2014

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La tesis del Yo en los §§ 7-12 de la segunda introducción y en el primer capítulo del ensayo de una nueva exposición de la Doctrina de la ciencia de Fichte (GA I/4, 491-534)
Authors: Macedo Rodríguez Gustavo
Published: July 2014

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La dimensión cognitiva de las pasiones: la vigencia de Aristóteles en la psicología moral contemporánea
Authors: Garrocho Salcedo Diego S.
Published: July 2014

Nuestra tradición filosófica ha dedicado no pocos esfuerzos a desentrañar la siempre problemática relación entre la razón y las pasiones, una dicotomía que habrá de remitirnos necesariamente a los conceptos griegos de λόγος y πάθος. Desde William James hasta nuestros días, la ciencia ha subrayado la dimensión cognitiva de las pasiones (Lazarus) así como su necesario concurso en la construcción de ciertas categorías morales (Prinz). En línea con algunas investigaciones recientes que defienden la vigencia del pensamiento de Aristóteles en neurociencia contemporánea (e.g., D.M. Gross) en este artículo trataremos de rastrear el origen aristotélico de esta teoría dominante en la psicología actual. Para ello —y aunque ya Platón empleara categorías epistemológicas para describir el placer— proponemos examinar específicamente la relación que Aristóteles establece entre los conceptos de αἴσθησις y πάθος (atendiendo especialmente a algunos pasajes de Ética Nicomáquea y De Ánima). Basándonos en estudios como los que han llevado a cabo Deborah Achtenberg, Martha Nussbaum o John M. Cooper, en este artículo trataremos de justificar la implícita vigencia de la descripción aristotélica de las pasiones en torno a tres rasgos fundamentales: su cualidad intencional, su implicación en la percepción del valor y su relevancia moral.
Atribuciones psicológicas, competencia y posesión conceptual desde el externismo psicológico
Authors: Andrés Balsera Silvia
Published: July 2014

El objetivo de este artículo es aportar unos criterios para determinar, desde un punto de vista externista, la posesión de un concepto por parte de hablantes semi-competentes. Tomando en consideración un ejemplo de T. Burge, presentaremos la noción de «atribución canceladora» con el objetivo de explicar por qué en ocasiones podemos usar un término general en posición oblicua para especificar las actitudes psicológicas de un individuo aunque éste carezca del concepto expresado por el término relevante.
Eternidad y emanatismo en la Guia de Perplejos de Maimónides
Authors: Beltrán Miquel
Published: July 2014

Una de las cuestiones más controvertidas que trata Maimónides en la Guia de Perplejos, que muchos estudiosos han considerado irresoluble, es la de dirimir entre la creación del mundo vs. la eternidad del mismo. La solución a la dicotomía puede encontrarse en la postulación de una creatio ab aeterno que se halla presente en algunos pasajes de la obra, y que se entiende como el sentido esotérico del esquema de la creación que parece describir el Genesis, vinculada —tal postulación— a una peculiar consideración de la voluntad divina, y descrita asimismo como un emanatismo con el que Maimónides identifica la acción de Dios en el universo.
El amor: ¿pasión, sentimiento, estado? revisión de relevantes tesis del s. xx
Authors: Sellés Juan Fernando
Published: July 2014

En este trabajo revisamos tres tesis sobre el amor de diferentes autores del s.XX pertenecientes a diversas escuelas de pensamiento, a saber: a) el amor es una pasión: Marcuse,Fromm y Sartre; b) el amor es un sentimiento: Haecker, Hildebrand y Arendt; c) el amor es un estado: Laín Entralgo, Julián Marías y M. Cabada.
Filosofía y ciencia en el pensamiento reaccionario español durante la II República. La figura de José Pemartín
Authors: Castro Sánchez Álvaro
Published: July 2014

La relación de la Filosofía con las ciencias y en concreto, con los avances dela física moderna y las matemáticas de comienzos del siglo XX, ha sido uno de los rasgos característicos de algunas de las mejores carreras filosóficas españolas, comenzando por la obrade Ortega y Gasset o Zubiri. Pero las preocupaciones que los nuevos descubrimientos suscitaron, desde sus implicaciones ontológicas hasta el rango mismo del pensamiento filosófico respecto a otros saberes, también fueron objeto de reflexión para pensadores tradicionalistas o semireaccionarios vinculados a la Iglesia o a los grupos y partidos autoritarios que provocarán la Guerra Civil y ocuparán los primeros puestos de la filosofía académica en los años cuarenta. Aquí estudiaremos el caso concreto del filósofo José Pemartín durante los años previos a la guerra, cuando trató problemas centrales de la Filosofía y la Ciencia de su tiempo y esbozó una ontología de lo temporal como respuesta.
El concepto aristotélico de ciencia y la dialéctica como práctica
Authors: Mas Torres Salvador
Published: July 2014

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Las creencias en la vida humana (una aproximación a la distinción orteguiana entre ideas y creencias)
Authors: Lasaga Medina José
Published: July 2014

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RESEÑA de : Heidegger, Martin. Die Grundbegriffe der antiken Philosophie : Gesamtausgabe II: Abteilung : Vorlesungen 1919—1944 : Band 22. Frankfurt am Main : Vittorio Klostermann, 1993
Authors: Uscatescu Barrón Jorge
Published: July 2014

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Popper, la noción absoluta de verdad y relativismo
Authors: Fernández Moreno Luis
Published: July 2014

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El impacto del humanismo renacentista en la concepción de la lógica
Authors: Castrillo Criado Pilar
Published: July 2014

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La retórica de la ciencia: orígenes y perspectivas de un proyecto de estudio de la ciencia.
Authors: Gómez Ferri Javier
Published: July 2014

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Estructura y contenido de la interpretación: una introducción a la teoría de la racionalidad de Donald Davidson
Authors: Castillo Ramón del
Published: July 2014

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RESEÑA de : Solís, Carlos. Razones e Intereses : la historia de la Ciencia después de Kuhn. Barcelona : Paidós, 1994
Authors: Armero Sanjosé Julio César
Published: July 2014

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Asín Palacios y el filósofo zaragozano Avempace
Authors: Lomba Fuentes Joaquín
Published: July 2014

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La antinomia Physis-Nomos en la Política, de Aristóteles
Authors: Samaranch Kirner Francisco
Published: July 2014

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RESEÑA de : Hodegger, Martín. Schelling : Vom Wesen der menschlichen Freiheit Gesamtausgabe; II. Abteilung : Vorlesvingen : 1919-1944; Band 42 : Herausgeberin Ingrid Schlüfiler. Frankfurt am Main : Vittorio Klostermann, 1988. Y Die Metaphysik des deutschen Idealismus (Schelling); Band 49 : Herausgeber Günther Seubold. Frankfurt am Main : Vittorio Klostermann, 1991
Authors: Uscatescu Barrón Jorge
Published: July 2014

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RESEÑA de : Bennington, G.; Derrida, J. Jacques Derrida. Madrid : Cátedra, 1994
Authors: Vidarte Francisco Javier
Published: July 2014

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Los inicios de la retórica aristotélica: el Grilo
Authors: Femenías María Luisa
Published: July 2014

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La definición del amor: una aproximación desde la teoría del conocimiento de Spinoza.
Authors: Rincón Jesús
Published: July 2014

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Unamuno: una aportación a la filosofía de la religión
Authors: Abella Maeso María José
Published: July 2014

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RESEÑA de : Schlegel, R. Poesía y Filosofía. Madrid, Alianza Universidad, 1994
Authors: Osuna Ruiz Jorge Luis
Published: July 2014

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Un aliento poético: el alfabeto
Authors: Pérez Cortés Sergio
Published: July 2014

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El orden en el caos : una ampliación del mecanicismo
Authors: Massa Rincón Francisco Javier
Published: July 2014

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El esquematismo de los conceptos matemáticos : una interpretación
Authors: Arenas Luis
Published: July 2014

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La constitución del paradigma de la física matemática clásica
Authors: Arbaizar Gil Benito
Published: July 2014

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Marin Mersenne : la polémica acerca de la pluralidad de los mundos en las "Quaestiones celeberrimae in Genesim" y sobre el intinitismo de Giordano Bruno en "L'impiété des déistes, athées et libertins de ce temps"
Authors: Rodríguez Carlos
Published: July 2014

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Althusser : pensar (en) los límites del Psicoanálisis
Authors: Vidarte Francisco Javier
Published: July 2014

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RESEÑA de : Sánchez Meca, D. La Historia de la Filosofía como Hermenéutica. Madrid : UNED, 1996
Authors: Aguilar García Raul
Published: July 2014

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Los argumentos lingüísticos de Kuhn
Authors: Armero Sanjosé Julio César
Published: July 2014

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Recuperar la retórica : T.S. Kuhn y las ciencias sociales
Authors: Alvarez Alvarez José Francisco
Published: July 2014

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Dendrobium georgei : A new species from southern Western Ghats, India
Authors: Mathew Jose
Published: July 2014

Dendrobium georgei (Orchidaceae) is described as a new species from southern Western Ghats, India.
Attribution of interminima changes in the global thermosphere and ionosphere
Authors: Emmert J. T. , McDonald S. E. , Drob D. P. , Meier R. R. , Lean J. L. , Picone J. M.
Published: July 2014

We present a statistical attribution analysis of the changes in global annual average thermospheric mass density and ionospheric total electron content (TEC) between the cycle 22/23 solar minimum (which occurred at epoch 1996.4) and the prolonged cycle 23/24 minimum (2008.8). The mass density data are derived from orbital drag, and the TEC data are derived from ground‐based GPS receivers. The interminima change in mass density was −36% relative to the 1996.4 yearly average. Considering each multiplicative forcing independently, lower average geomagnetic activity during the cycle 23/24 minimum produced an interminima density change of at least −14%, solar extreme ultraviolet (EUV) irradiance forcing produced a density change of −1% to −13%, and changes in thermospheric CO2 concentration produced a density change of −5%. There was essentially no interminima change in global TEC derived from ground‐based GPS receivers or space‐based altimeters, even though past behavior suggests that it should have changed −3% (0.2 TEC units (1 TECU = 1016 el m−2)) in response to lower geomagnetic activity and −1% to −9% (0.1–0.8 TECU) in response to lower EUV irradiance. There is large uncertainty in the interminima change of solar EUV irradiance; the mass density and TEC data suggest a plausible range of 0% to −6%.
Multiscale dynamical analysis of a high‐resolution numerical model simulation of the Solomon Sea circulation
Authors: Djath Bughsin' , Verron Jacques , Melet Angelique , Gourdeau Lionel , Barnier Bernard , Molines Jean‐Marc
Published: July 2014

A high 1/36° resolution numerical model is used to study the ocean circulation in the Solomon Sea. An evaluation of the model with (the few) available observation shows that the 1/36° resolution model realistically simulates the Solomon Sea circulations. The model notably reproduces the high levels of mesoscale eddy activity observed in the Solomon Sea. With regard to previous simulations at 1/12° resolution, the average eddy kinetic energy levels are increased by up to ∼30–40% in the present 1/36° simulation, and the enhancement extends at depth. At the surface, the eddy kinetic energy level is maximum in March‐April‐May and is minimum in December‐January‐February. The high subsurface variability is related to the variability of the western boundary current (New Guinea Coastal Undercurrent). Moreover, the emergence of submesoscales is clearly apparent in the present simulations. A spectral analysis is conducted in order to evidence and characterize the modeled submesoscale dynamics and to provide a spectral view of scales interactions. The corresponding spectral slopes show a strong consistency with the Surface Quasi‐Geostrophic turbulence theory.
Detection of spatially limited high‐porosity layers using crosshole GPR signal analysis and full‐waveform inversion
Authors: Klotzsche Anja , van der Kruk Jan , Bradford John , Vereecken Harry
Published: July 2014

High‐permittivity layers, related to high‐porosity layers or impermeable clay lenses, can act as low‐velocity electromagnetic waveguides. Electromagnetic wave phenomena associated with these features are complicated, not well known and not easy to interpret in borehole GPR data. Recently, a novel amplitude analysis approach was developed that is able to detect continuous low‐velocity waveguides and their boundaries between boreholes by using maximum and minimum positions of the trace energy profiles in measured GPR data. By analyzing waveguide models of different thickness, dip, extent, permittivity, and conductivity parameters, we extend the amplitude analysis to detect spatially limited or terminated waveguides. Waveguides that show high‐amplitude elongated wave trains are most probably caused by a change in porosity rather than a change in clay content. In a crosshole GPR data set from the Boise Hydrogeophysical Research Site, two terminated wave‐guiding structures were detected using the extended amplitude analysis. Information gained from the amplitude analysis improved the starting model for full‐waveform inversion which imaged the lateral extent and thickness of terminated waveguides with high resolution. Synthetic data calculated using the inverted permittivity and conductivity models show similar amplitudes and phases, as observed in the measured data, which indicates the reliability of the obtained models. Neutron‐Neutron logging data from three boreholes confirm the changes in porosity and indicate that these layers were high‐porosity sand units within low‐porosity, poorly sorted sand, and gravel units.
Correlated patterns in hydrothermal plume distribution and apparent magmatic budget along 2500 km of the Southeast Indian Ridge
Authors: Baker Edward T. , Hémond Christophe , Briais Anne , Maia Marcia , Scheirer Daniel S. , Walker Sharon L. , Wang Tingting , Chen Yongshun John
Published: July 2014

Multiple geological processes affect the distribution of hydrothermal venting along a mid‐ocean ridge. Deciphering the role of a specific process is often frustrated by simultaneous changes in other influences. Here we take advantage of the almost constant spreading rate (65–71 mm/yr) along 2500 km of the Southeast Indian Ridge (SEIR) between 77°E and 99°E to examine the spatial density of hydrothermal venting relative to regional and segment‐scale changes in the apparent magmatic budget. We use 227 vertical profiles of light backscatter and (on 41 profiles) oxidation‐reduction potential along 27 first and second‐order ridge segments on and adjacent to the Amsterdam‐St. Paul (ASP) Plateau to map ph, the fraction of casts detecting a plume. At the regional scale, venting on the five segments crossing the magma‐thickened hot spot plateau is almost entirely suppressed (ph = 0.02). Conversely, the combined ph (0.34) from all other segments follows the global trend of ph versus spreading rate. Off the ASP Plateau, multisegment trends in ph track trends in the regional axial depth, high where regional depth increases and low where it decreases. At the individual segment scale, a robust correlation between ph and cross‐axis inflation for first‐order segments shows that different magmatic budgets among first‐order segments are expressed as different levels of hydrothermal spatial density. This correlation is absent among second‐order segments. Eighty‐five percent of the plumes occur in eight clusters totaling ∼350 km. We hypothesize that these clusters are a minimum estimate of the length of axial melt lenses underlying this section of the SEIR.
Improved short‐term variability in the thermosphere‐ionosphere‐mesosphere‐electrodynamics general circulation model
Authors: Häusler K. , Hagan M. E. , Baumgaertner A. J. G. , Maute A. , Lu G. , Doornbos E. , Bruinsma S. , Forbes J. M. , Gasperini F.
Published: July 2014

We report on a new source of tidal variability in the National Center for Atmospheric Research thermosphere‐ionosphere‐mesosphere‐electrodynamics general circulation model (TIME‐GCM). Lower boundary forcing of the TIME‐GCM for a simulation of November–December 2009 based on 3‐hourly Modern‐Era Retrospective Analysis for Research and Application (MERRA) reanalysis data includes day‐to‐day variations in both diurnal and semidiurnal tides of tropospheric origin. Comparison with TIME‐GCM results from a heretofore standard simulation that includes climatological tropospheric tides from the global‐scale wave model reveal evidence of the impacts of MERRA forcing throughout the model domain, including measurable tidal variability in the TIME‐GCM upper thermosphere. Additional comparisons with measurements made by the Gravity field and steady‐state Ocean Circulation Explorer satellite show improved TIME‐GCM capability to capture day‐to‐day variations in thermospheric density for the November–December 2009 period with the new MERRA lower boundary forcing.
The influence of melting and melt drainage on crustal rheology during orogenesis
Authors: Diener Johann F. A. , Fagereng Åke
Published: July 2014

Partial melting significantly weakens crustal rocks by introducing a low‐viscosity liquid phase. However, near‐concomitant melt drainage can remove this weak phase, potentially reversing the rheological effects such that the strength of a specific lithology depends on when the prograde pressure‐temperature path intersects a melting reaction, how much melt is produced, and how long this melt is retained before it is lost. Phase equilibria and mixed rheology modeling of typical metapelite and metagreywacke compositions indicate that these rocks undergo continuous but pulsed melt production during prograde metamorphism. Depending on whether melt removal is continuous or episodic, and assuming geological strain rates, the lithologies can retain a very low strength less than 1 MPa or transiently strengthen to ∼5 MPa following melt loss. Lithologies undergoing episodic melt loss can therefore cycle between being relatively weak and relatively strong components within a composite crustal section. Melt production, retention, and weakening in the middle to lower crust as a whole is more sustained during heating and melt production, consistent with geodynamic inferences of weak, melt‐bearing lower crust. However, the long‐term consequence of melting and melt loss is a 50–400% increase in the strength of residual lithologies. The strengthening is more pronounced in metapelite than metagreywacke and is achieved through a combination of dehydration and the removal of the weak mica framework coupled to increased proportions of strong feldspars and garnet. Despite prolonged weakness, melting and melt loss therefore ultimately result in a dry and elastic lower crust.
Modeling spatiotemporal impacts of hydroclimatic extremes on groundwater recharge at a Mediterranean karst aquifer
Authors: Hartmann Andreas , Mudarra Matías , Andreo Bartolomé , Marín Ana , Wagener Thorsten , Lange Jens
Published: July 2014

Karst aquifers provide large parts of the water supply for Mediterranean countries, though climate change is expected to have a significant negative impact on water availability. Recharge is therefore a key variable that has to be known for sustainable groundwater use. In this study, we present a new approach that combines two independent methods for karst recharge estimation. The first method derives spatially distributed information of mean annual recharge patterns through GIS analysis. The second is a process‐based karst model that provides spatially lumped but temporally distributed information about recharge. By combining both methods, we add a spatial reference to the lumped simulations of the process‐based model. In this way, we are able to provide spatiotemporal information of recharge and subsurface flow dynamics also during varying hydroclimatic conditions. We find that there is a nonlinear relationship between precipitation and recharge rates resulting in strong decreases of recharge following even moderate decreases of precipitation. This is primarily due to almost constant actual evapotranspiration amounts despite varying hydroclimatic conditions. During the driest year in the record, almost the entire precipitation was consumed as actual evapotranspiration and only little diffuse recharge took place at the high altitudes of our study site. During wettest year, recharge constituted a much larger fraction of precipitation and occurred at the entire study site. Our new method and our findings are significant for decision makers in similar regions that want to prepare for possible changes of hydroclimatic conditions in the future.
Un détail de ce qui change: Function of a Function
Authors: Macapia Peter
Published: July 2014

Why should computation be leading to a bifurcation in architectural detailing, resulting in a simultaneous, and opposing, tendency towards either greater precision in fabrication or increasing plasticity? Architectural designer and theorist Peter Macapia asks what is driving these propensities in computation, and what in turn historically might be the relation between the detail and force. What comes into play now, though, when architectural style is no longer identified by a taxonomy of parts, or a vocabulary of orders, but rather by a network of forces and functions correlating actions? How might economic and political power be interacting with force, the diagram and function in contemporary design?
Tenogenic Induction of Human MSCs by Anisotropically Aligned Collagen Biotextiles
Authors: Younesi Mousa , Islam Anowarul , Kishore Vipuil , Anderson James M. , Akkus Ozan
Published: July 2014

A novel biofabrication modality, electrophoretic compaction with macromolecular alignment, is utilized to make collagen threads that mimic the native tendon's structure and mechanical properties. A device with kinematic electrodes is designed to fabricate collagen threads in continuous length. For the first time, a 3D‐biotextile is woven purely from collagen. Mechanical properties and load‐displacement behavior of the biotextile mimic those of the native tendon while presenting a porosity of 80%. The open pore network facilitates cell seeding across the continuum of the bioscaffold. Mesenchymal stem cells (MSCs) seeded in the woven scaffold undergo tenogenic differentiation in the absence of growth factors and synthesize a matrix that is positive for tenomodulin, COMP and type I collagen. Up‐regulation of tenomodulin, a tendon specific marker, is 11.6 ± 3.5 fold, COMP is up‐regulated 16.7 ± 5.5 fold, and Col I is up‐regulated 6.9 ± 2.7 fold greater on ELAC threads when compared to randomly oriented collagen gels. These results demonstrate that a bioscaffold woven using collagen threads with densely compacted and anisotropically aligned substrate texture stimulates tenogenesis topographically, rendering the electrochemically aligned collagen as a promising candidate for functional repair of tendons and ligaments.
Enhancement of the Grain Boundary Conductivity in Ceramic Li0.34La0.55TiO3 Electrolytes in a Moisture‐Free Processing Environment
Authors: Aguesse Frederic , López del Amo Juan Miguel , Roddatis Vladimir , Aguadero Ainara , Kilner John A.
Published: July 2014

The grain boundary resistivity problem of highly conductive bulk Li0.34La0.55TiO3 perovskite has been investigated by means of impedance spectroscopy and solid‐state NMR of samples processed in controlled atmospheres. The samples were sintered in air, synthetic air, and oxygen, in which the level of moisture varied. A dry atmosphere is critical to obtain dense ceramics with a low grain boundary resistivity. The grain boundary conductivity is five times higher for samples sintered in oxygen atmosphere due to the suppression of Li2CO3 secondary phase formation, which is responsible for low lithium ion diffusion at the grain boundary.
Multi‐Modal, Surface‐Focused Anticoagulation Using Poly‐2‐methoxyethylacrylate Polymer Grafts and Surface Nitric Oxide Release
Authors: Gupta Surbhi , Amoako Kagya A. , Suhaib Ahmed , Cook Keith E.
Published: July 2014

This study examines platelet adhesion on surfaces that combine coatings to limit protein adsorption along with “anti‐platelet” nitric oxide (NO) release. Uncoated and poly‐2‐methoxyethylacrylate (PMEA) coated, gas permeable polypropylene (PP) membranes were placed in a bioreactor to separate plasma and gas flows. Nitrogen with 100/500/1000 ppm of NO was supplied to the gas side as a proof of concept. On the plasma side, platelet rich plasma (PRP, 1 × 108 cell/mL) was recirculated at low (60)/high (300) flows (mL/min). After 8 hours, adsorbed platelets on PP was quantified via a lactate dehydrogenase assay. Compared to plain PP, the PMEA coating alone reduced adsorption by 17.4 ± 9.2% and 29.6 ± 16.6% at low and high flow (p < 0.05), respectively. NO was more effective at low plasma flow. At 100 and 500 ppm of NO, adsorption fell by 37.9 ± 6.1% and 100 ± 4.7%, (p < 0.001), on plain PP. At high flow with 100, 500, and 1000 ppm of NO, adsorption reduced by 17.9 ± 17.8%, 46.4 ± 23.2%, and 100 ± 4.8%, (p < 0.001), respectively. On PMEA‐coated PP with only 100 ppm, adsorption fell by 69.7 ± 6.8 and 65.6% ± 16.9%, (p < 0.001), at low and high flows respectively. Therefore, the combination of an anti‐adsorptive coating with NO has great potential to reduce platelet adhesion and coagulation at biomaterial surfaces.
Gold‐ and Silver‐Catalyzed [4+2] Cycloadditions of Ynamides with Oxetanes and Azetidines
Authors: Pawar Samir Kundlik , Vasu Dhananjayan , Liu Rai‐Shung
Published: July 2014

Gold‐catalyzed [4+2] cycloadditions between ynamides and oxetanes are described; these reactions involve oxetanes and gold‐π‐ynamides as nucleophiles and electrophiles, respectively. Excellent cycloaddition regioselectivities are achieved over a reasonable range of ynamide and oxetane substrates. For azetidines, their [4+2] cycloadditions with ynamides are implemented more efficiently with silver hexafluoroantimonate, which is also compatible with various ynamides and azetidines. These two cycloadditions provide facile accesses to six‐membered heterocycles such as 6‐amino‐3,4‐dihydro‐2H‐pyrans and 2‐amino‐1,4,5,6‐tetrahydropyridines.

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Phosphine‐Free, Efficient Double Carbonylation of Aryl Iodides with Amines Catalyzed by Water‐Insoluble and Water‐Soluble N‐Heterocyclic Carbene–Amine Palladium Complexes
Authors: Wang Yan , Yang Xiaolong , Zhang Chunyan , Yu Jianqiang , Liu Jianhua , Xia Chungu
Published: July 2014

The water‐insoluble and water‐soluble N‐heterocyclic carbene (NHC)–amine palladium complexes, Ipr‐Pd(deba)Cl and SO3‐Ipr‐Pd(deba)Cl, were synthesized. Both catalysts exhibit excellent activity in the phosphine‐free double carbonylation of aryl iodides with amines to produce α‐keto amides. Moreover, as the water‐soluble catalyst exhibits significant compatibility in the aqueous phase with the activities of different Pd‐NHC complexes, we conclude that the intramolecular amine ligand strongly affects the selectivity of the products in double carbonylation reaction and serves as an alternative of phosphine ligands.

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Regio‐ and Stereoselective Dimerization of Arylacetylenes and Optical and Electrochemical Studies of (E)‐1,3‐Enynes
Authors: Morozov Oleg S. , Asachenko Andrey F. , Antonov Denis V. , Kochurov Vitaly S. , Paraschuk Dmitry Yu. , Nechaev Mikhail S.
Published: July 2014

The N‐heterocyclic carbene palladium complex (SIPr)Pd(cinnamyl)Cl [SIPr=N,N′‐bis(2,4,6‐trimethylphenyl)‐4,5‐dihydroimidazol‐2‐ylidene) promotes regio‐ and stereospecific dimerization of a variety of arylalkynes to give (E)‐1,3‐enynes in good to excellent yields. An efficient and practical procedure for their synthesis was developed using a biphasic aqueous alkali/heptane system. Optical and electronic properties of (E)‐1,3‐enynes are highly tunable. Depending on the nature of the substituents, HOMO energies vary in the range 5.3–6.0 eV. (E)‐1,3‐Enynes can exhibit intense photoluminescence in the spectral region 350–500 nm.

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A Sulfur Ylides‐Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated and Alkynylated Benzene Derivatives
Authors: Gao Fei , Huang You
Published: July 2014

An efficient domino benzannulation strategy with the participation of sulfur ylides for the construction of biaryl compounds is disclosed. It could also be extended to the synthesis of alkenylated and alkynylated benzene derivatives under mild conditions. This versatile strategy combined with traditional metal‐catalyzed cross‐coupling methods should offer a practical route to construct complex multiaryl compounds.

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De novo acute myeloid leukemia with 20–29% blasts is less aggressive than acute myeloid leukemia with ≥30% blasts in older adults: a Bone Marrow Pathology Group study
Authors: Hasserjian Robert Paul , Campigotto Federico , Klepeis Veronica , Fu Bin , Wang Sa A. , Bueso‐Ramos Carlos , Cascio Michael Joseph , Rogers Heesun Joyce , Hsi Eric Darryl , Soderquist Craig , Bagg Adam , Yan Jiong , Ochs Rachel , Orazi Attilio , Moore Frank , Mahmoud Amer , George Tracy Irene , Foucar Kathryn , Odem Jamie , Booth Cassie , Morice William , DeAngelo Daniel J. , Steensma David , Stone Richard Maury , Neuberg Donna , Arber Daniel Alan
Published: July 2014

It is controversial whether acute myeloid leukemia (AML) patients with 20–29% bone marrow (BM) blasts, formerly referred to as refractory anemia with excess blasts in transformation (RAEBT), should be considered AML or myelodysplastic syndrome (MDS) for the purposes of treatment and prognostication. We retrospectively studied 571 de novo AML in patients aged >50 years, including 142 RAEBT and 429 with ≥30% blasts (AML30), as well as 151 patients with 10–19% BM blasts (RAEB2). RAEBT patients were older and had lower white blood count, but higher hemoglobin, platelet count, and karyotype risk scores compared to AML30, while these features were similar to RAEB2. FLT3 and NPM1 mutations and monocytic morphology occurred more commonly in AML30 than in RAEBT. RAEBT patients were treated less often with induction therapy than AML30, whereas allogeneic stem cell transplant frequency was similar. The median and 4‐year OS of RAEBT patients were longer than those of AML30 patients (20.5 vs 12.0 months and 28.6% vs 20.4%, respectively, P = 0.003); this difference in OS was manifested in patients in the intermediate UKMRC karyotype risk group, whereas OS of RAEBT patients and AML30 patients in the adverse karyotype risk group were not significantly different. Multivariable analysis showed that RAEBT (P < 0.0001), hemoglobin (P = 0.005), UKMRC karyotype risk group (P = 0.002), normal BM karyotype (P = 0.004), treatment with induction therapy (P < 0.0001), and stem cell transplant (P < 0.0001) were associated with longer OS. Our findings favor considering de novo RAEBT as a favorable prognostic subgroup of AML. Am. J. Hematol. 89:E193–E199, 2014. © 2014 Wiley Periodicals, Inc.
Tau reduction prevents disease in a mouse model of Dravet syndrome
Authors: Gheyara Ania L. , Ponnusamy Ravikumar , Djukic Biljana , Craft Ryan J. , Ho Kaitlyn , Guo Weikun , Finucane Mariel M. , Sanchez Pascal E. , Mucke Lennart
Published: July 2014

Objective

Reducing levels of the microtubule‐associated protein tau has shown promise as a potential treatment strategy for diseases with secondary epileptic features such as Alzheimer disease. We wanted to determine whether tau reduction may also be of benefit in intractable genetic epilepsies.

Methods

We studied a mouse model of Dravet syndrome, a severe childhood epilepsy caused by mutations in the human SCN1A gene encoding the voltage‐gated sodium channel subunit Nav1.1. We genetically deleted 1 or 2 Tau alleles in mice carrying an Nav1.1 truncation mutation (R1407X) that causes Dravet syndrome in humans, and examined their survival, epileptic activity, related hippocampal alterations, and behavioral abnormalities using observation, electroencephalographic recordings, acute slice electrophysiology, immunohistochemistry, and behavioral assays.

Results

Tau ablation prevented the high mortality of Dravet mice and reduced the frequency of spontaneous and febrile seizures. It reduced interictal epileptic spikes in vivo and drug‐induced epileptic activity in brain slices ex vivo. Tau ablation also prevented biochemical changes in the hippocampus indicative of epileptic activity and ameliorated abnormalities in learning and memory, nest building, and open field behaviors in Dravet mice. Deletion of only 1 Tau allele was sufficient to suppress epileptic activity and improve survival and nesting performance.

Interpretation

Tau reduction may be of therapeutic benefit in Dravet syndrome and other intractable genetic epilepsies. Ann Neurol 2014;76:443–456
Integration of Platinum Nanoparticles with a Volumetric Bar‐Chart Chip for Biomarker Assays
Authors: Song Yujun , Xia Xuefeng , Wu Xifeng , Wang Ping , Qin Lidong
Published: July 2014

Platinum nanoparticles (PtNPs) efficiently catalyze the transformation of H2O2 into oxygen gas. However, owing to the lack of an efficient approach or device that can measure the produced oxygen gas, the catalytic reaction has never been used for diagnostic applications. Microfluidics technology provides a platform that meets these requirements. The volumetric bar‐chart chip (V‐Chip) volumetrically measures the production of oxygen gas by PtNPs and can be integrated with ELISA technology to provide visible and quantitative readouts without expensive instrumentation or complicated data processing. Herein we show that PtNPs outperform catalase with respect to stability at high H2O2 concentrations or temperatures or in long‐term reactions, and are resistant to most catalase inhibitors. We also show that the catalase‐like activity of PtNPs can be used in combination with the V‐Chip to sensitively and specifically detect cancer biomarkers both in serum and on the cell surface.
Photothermal Conversion of CO2 into CH4 with H2 over Group VIII Nanocatalysts: An Alternative Approach for Solar Fuel Production
Authors: Meng Xianguang , Wang Tao , Liu Lequan , Ouyang Shuxin , Li Peng , Hu Huilin , Kako Tetsuya , Iwai Hideo , Tanaka Akihiro , Ye Jinhua
Published: July 2014

The photothermal conversion of CO2 provides a straightforward and effective method for the highly efficient production of solar fuels with high solar‐light utilization efficiency. This is due to several crucial features of the Group VIII nanocatalysts, including effective energy utilization over the whole range of the solar spectrum, excellent photothermal performance, and unique activation abilities. Photothermal CO2 reaction rates (mol h−1 g−1) that are several orders of magnitude larger than those obtained with photocatalytic methods (μmol h−1 g−1) were thus achieved. It is proposed that the overall water‐based CO2 conversion process can be achieved by combining light‐driven H2 production from water and photothermal CO2 conversion with H2. More generally, this work suggests that traditional catalysts that are characterized by intense photoabsorption will find new applications in photo‐induced green‐chemistry processes.