bluuebunny/crossref_metadata_2025 huggingface dataset:
Study the biological activity of some antibiotics and theircomplexes, with some metals
Authors: A. Al-Tai Heyam , T. Hameed Rawaa , O. Al-Allaf Yasser
Published: September 2023

The research is concemed with studying of activity of some antibiotics (Tetracycline, Gentamycine and streptomycine) and their complexes with some metal (Ca, Mg ,Fe) were been studied by electric conductivity, ultraviolet spectroscopy (UV) to compare the biological effects of these complexes with the physiochemical methods for determination of this complexes such as association constant Ka, equivalente conductance (A) at infinit dilution and the distance between ions in solution R at the best fit values of standard deviation (c'A) which are caloulated for each antibiotic and their complexes with the absorbance of these complexes in neutral medium at room temperature.
Comparative spectrophoto metric determination of h rip rotidinehydrochloride drug (TPH) using oxidizing agents Potassiumpermanganate & Potassium dichromate
Authors: Ahmed Mohammad Al-Rashidy Asmaa
Published: September 2023

This research deals with spectrophotometric method for determination of Triprolidine Hydrochloride drug (TPH) using two different oxidizing agents; Potassium permanganate and Potassium dichromate .The analytical results obtained are as follow :1- The alkaline media (NaOH): Potassium permanganate gives green solution which gives spectrum with amaximum absorption at 612nm its found that optimum conc. for alkaline solution is 1.2X10 'M and 1X10>M for Potassium permanganate within 10 minutes oxidizing time. The statistical and other analytical results for drug concentration range (1-12) ppm are as follows: Correlation coefficient r = 0.9989 , molar absorption coefficient 26993 L/mol.cm and sandel’s sensitivity is 0.0122pg/cm? at Apa =612nm. This method is applied for the determination of TPH in pharmaceutical preparations with percentage recovery not less than 96.22 %. 2-The acidic media (HCI): Potassium dichromate gives yellow solution with amaximum absorption at 350 nm the optimum conc for acidic solution is 1X10% M and 1.5X10°M for Potassium dichromate duringl5 minutes oxidizing time. The statistical and other analytical results for drug concentration range (1-12) ppm are as follows: Correlation coefficient r = 0.9969, molar absorption coefficient 38559.5 L/mol.cm and sandel’s sensitivity is 0. 0086pg/cm? at Amax =350nm This method is applied for the determination of TPH in pharmaceutical preparations with percentage recovery not less than 94.66%.
Seasonal effect on Physiological Parameters and PulmonaryFunction Test
Authors: Ali Salih Jawad , Fawze Al-Kotibi Mohammed , Jehad M. Abdul-Rahman
Published: September 2023

Considerable information are accumulated about normal composition of blood. i80) males and (50) females attended this study aged from 18-40 years to investigate the effect of season on some blood parameters. The samples of venous blood were collected at the October 2A07 b May 2008. All blood parameters hemoglobin (Hb), packed cell volume (PC.V.), red blood cells (RBCs), mean corpuscular volume (MCV), mean cell hemoglobin (MCH) of males and females were within normal range of healthy subjects and also MCHC mean cell hemoglobin concentration was normal. There were significant different differences between the male and female students. There was no significant effect of season on blood parameters. The pulmonary function test included the measurement of peak flow meter and respiratory volume. There are significant differences in the value of pulmonary function between male and female students.
Trichomonas vaginalis Among Women in Sulaimania Governorate-Iraq
Authors: O.D. Fattah Chuar , A. Kadir Mohammed
Published: September 2023

Trichomonas vaginalis infection is one of the sexually transmitted diseases. It is a health problem all over the world, including Iraq. The parasite usually infected in the vagina and urethra, but could involve the endocervix. Aim: This study aim to show the prevalence of Trichomonas vagina/is in the women that have vaginal discharge. The study included ( 600) women attended the gynecological out patient clinic in Sulaimania obstetrical and gynecological teaching hospital and rozhan out patient clinic tlu·ough the period from January 2007 till September 2007. Per vaginal examination was performed for each patient using a sterile cuscos speculum. Two high vaginal swabs were obtained from each patient one for direct microscopic examination and other for Trichomonas vagina/is culture. The prevalence of T. vaginalis was 1 0( 1. 66%) The infection rate between pregnant women was 8(1.77%) higher than that of non-pregnant women 2(1.33%). The highest is found in women at the age group (26-3 5) years in which the infection rate was 5(2.48%). The rate of infection was higher among uneducated women 9(1.5%) than educated ones. The higher rate of T. vaginalis was obtained from women with white to gray (frothy discharge) 6(1.57%) and with yellow to green discharge 4(1.81 %) and those with bad odor was 8(2.02%) was higher than odourless discharge 2(0.97%). In positive cases of T. vagina/is , 6(60%) had white to gray vaginal discharge, and the rate of bad odour (80%) and without bad odour (20%). The rate of infection among illiterate women was higher than those with school education and no positive cases were detected among those with college education. In cultures the rate ofT. vagina/is was (5%) while in direct wet mount examination was (1.66%). Candida albicans were detected in 167(83.5%) in selected culture media ofT. vaginalis
The residual cavity after hepatic hydatid endocystectomy:acomparative clinical study of the surgical options
Authors: Ali Aja Hassan
Published: September 2023

Background: hydatid cyst remains an important public health problem in endemic area. The liver is the organ most frequently infested by hyclatid disease and medical therapy alone is ineffective in eliminating the parasite. The surgical treatment technique for liver hydatid cyst can not be standardized, and the surgical technique should be tailored according co the extent of the cyst and any adjunct complications of hydatid disease. Objectives of the surgical intervention is evacuation ·and obliteration of the cystic caviry. Recurrent hydatid cyst is defined as a new growth of an echinococcal cyst after complete surgical removal of the primary one and irrespective to the surgical technique. Material and methods: A prospective study was including (90) patients who were surgically treated for hepatic hydatid cysts, during the period March 2005 to October 2009 in Baghdad and Tiksit Teaching Hospital. 49 patients (54%) were female and the remaining 41 patients (46%) were male. This gives female: males ratio of l.2: I. The surgical procedures were performed for all patients were endocystectomy ± omentoplasty or open peritoneal drainage or capitonnage; that's compared with regard of early and late postoperative complications and hydatid disease recurrence. The follow up was made in early and late postoperative period by abclom inal ultrasound up to 2 years (6 montbly intervals). Conclusion: abdominal ultrasound is useful easy tech.nique in postoperative fo[low-up. Bndocystectomy +Omentoplasty procedure had not comp I icated by recurrence. Prevention and control remain the best weapons lo eliminate hydati.dosis.
utilization of Lead citrate on the peripheral Nervous Systemin Rat (An Experimental and Histological Study)
Authors: Shahab Al-Tekrity Sabah , Hameed Ibraheem Ayad
Published: September 2023

administrated of lead citrate solution with phosphate buffer saline orally in a dose of 250 mg/kg for thirty days. Animais were divided into four groups. Group A survived for 30 days. Group B for 60 days. Group C fbr 90 days and Groupb tzO days. Twenty animals were administrated phosphate buffer saline for 30 clays and classified into four 4 groups and survived for 30,60,90 and 120 days afterthe last dose. Atthe end of eachperiod the animals were scarified and segments of the peripheral nerve (Sciatic nerve) were removed and fixed in osmic acid 1o/o , then processed in graded glycerin 500/o , pure glycerin for obtaining teased nerve fibers . Specimens tbr miiror"opi" examination were done by application of the histological technique for obtaining transverse and longitudinal sections of the 6um thickness. The results of the present itr,iy d"*onstrated that the peripheral nerve fibers were affected after the 30,and 60 days mostly reflected by the presence of the wallerian degeneration ( destrr-rction of the myelin sheath ancl axon) of the most nerve fibers and at the period of 90 days after the last dose was indicated a regeneration of the most nerve fibers , but still there cerlain percentage of the degeneratecl nerve f-rbers and irregular outlines of its myelin sheath. After 120 days, Remyelination of most nerve fibers were detected associated with short internodes in between other intact nodes of Ranvier .
The effect of Green lea aqueous extract Camellia sinensisand Vitamin E in infertile men in Tikrit city and It'sSuburbs
Authors: Mohammad Mubark AL- Mahdawi Zaid
Published: September 2023

This study investigated the effects of Green tea aqueous extract and Vitamin I effect on the fertility of men, and the antioxidant and unti-infenile activity for comparison. The study included examination of (281) samples of seminal fluid of men thar were suffering from infertility caused by gonorrhea n :(144) , Varicose n: (47) , seminal vessels narrow 0: (31) , different inflammations n: (59) samples . and (60) samples from normal individuals (subjects) as a control, for the period from March(2008) 10 April(2009) in Tikrit city and its surrounding. The results appeared that adminstratio of green tea extract alone or with Vit. E in an infertile men (Gonorrhea infections, Varicocele |, Seminal vessels narrow and different sexual inflammations) lead to significant increase (p<0.03) in total numbers , the average of movement and normal forms of sperm. The treatment with Vit. k alone lead to increase in numbers and normal forms of spermatozoa , however , no significant variations were of served in the average of movement. The results indicated that using green tes agueous exirct , VitE or both logether were effective to inducing significant increase in the concentrations of testosterone hormone. In noma) cases the results showed no significant variation in total numbers of sperms after with preen tea extract or ViLE adminstration. whereas acminstration both together showed a significant increase , also an increase in the average of movement and normal forms when patints treated with green tea extract alone or green extract incombination with VitFE bu no significant variations were observed when treated with Vit.E alone The results emphasized that using Vit. E or green tea extract or both together were effective in inducing a significant increase in the concentration of lestosicrone hormone The causes of the green lea extract effectivness relate 10 its consistence of antioxidants which reduced the free mdicals in the infertile men and caused an improvement of their fertility.
Role of Some Natural products as a Disinfectant on Color of GC-SoftLiner
Authors: Rabee Al-Sumaidae Rana
Published: September 2023

The study aims to evaluate the effect of some natural products (nigella sativa. sesame, flax amd ginger oil) (Emad factory/mosul/Iraq) in relation to nystutin suspension on color of GC-Soft Liner Fifly Sample were prepared frum-GC-extra soft lining material, they were (10*10%2mm). Half of the samples for each group were immersed for 8hr in these oils after they had been infected with Candida albicans and incubated [ur 48hr, the other half of the samples immersed for Bhr daily fur one month. This study compared antifungal efficiency before and after immersion in distilled water (Negative Control), nystatin suspension (100000 LU/ml as a positive control), nigella sativa, sesame, flax and ginger oil. Color of samples tested by Vita — Easy Shade system, the statistical tests used were analysis of variance, Durinet T-test. The resulls demonstrated that there were significant differences between all tested oils znd DW in refution to antifungal action, and no significant differences between all tested oils and D.W iu relation 0 color of GC-solt Lining maternal al (P=0.05). All the tested natural oils were effective antifungal agents and would be accepted and safe in relation to the color of soft hnet.
Diagnosis of cervical - Lymph adenopathyAccording to age groups
Authors: A. Saleh Anas
Published: September 2023

Cervical — Lymphadenopathy is common problem , both in children and adults. Aim of study . to determine the most professional — dinguosis ul cervical — Lymphadenopathy according to patient age . over period Lasting from Jan - 2007 to Nov . 2009 , prospective study of ( 83) patients from ( both sexes ), ( male : 51 ){ Female : 32) with cervical — Lymphadenopathy were taken and divided into two age groups ( pediatric age group < Sy ) and ( Adult age group 16-72 y) . Diagnosis of cervical —

Lymphadenopathy depend on clinical — examination , radiological — examination , FNA(Fine Needle Aspiration) , and in some cases excisional biopsy was taken. Result :

this study showed that inflammatory and infectious diseases had the highest incidence in pediatric age group ( 65.7%) of total pediatric cases , followed by primary malignant cervical — Lymphadcnopathy ( 25.7% ) , the lowest was the secondary imelasteses (8.6% )- while in adult age group secondary cervical Lymphedenopathy (metastases) was the commonest ( 41.71 ) Followed by infectious and inflammatory Lesion ( 37.51) , the Lowest was the primary ervival — Lymphadenopathy (20.8%) Conclusion : In this smudy infectious and inflammatory cervical — lymphadenopathy was the commonest in pediatric age group , while secondary cervical lymphadenopathy —( metasteses) was the commonest in adult age group .
Distributed Denial-of-Service Resilient Control for Urban Air Mobility Applications
Authors: Clarke Shanelle G. , Hwang Sounghwan , Thapliyal Omanshu , Hwang Inseok
Published: September 2023

Urban air mobility (UAM) systems are characterized by the heterogeneity of participating aerial vehicles (AVs). Participating AVs are expected to cooperate with each other while maintaining flexibility in individual missions and reacting to the possibility of cyberattacks and security threats. In this paper, we focus on the vulnerabilities of the UAM cyberphysical system against distributed denial-of-service (DDOS) cyberattacks. We develop a resilient control strategy for the AVs navigating through the UAM airspace to mitigate the effect of DDOS cyberattacks. A graph-theoretic vulnerability metric is proposed. Each AV can compute its vulnerability against DDOS cyberattacks in a fully distributed manner using this metric. Based on this computed metric, the AVs self-organize to minimize collision risk in the operating airspace after assessing self-vulnerability. This reconfiguration is also carried out in a fully distributed manner. The proposed resilient control is proven to reduce vulnerability in a probabilistic manner. This reduced vulnerability holds against DDOS cyberattacks with a known attack budget.
Numerical Investigation of Double Transonic Dip Behaviors in Supercritical Airfoil Flutter
Authors: Miyake Toma , Terashima Hiroshi
Published: September 2023

This numerical study examines the behavior of the double transonic dip with a supercritical airfoil. A two-dimensional model of a wing section with two degrees of freedom was used for the investigation. The flowfield was modeled by solving the unsteady Reynolds-averaged compressible Navier–Stokes equations using the Spalart–Allmaras turbulence model, and the equations of motion were solved to determine the structural dynamics. The present model successfully captured the behavior of the double transonic dip on the flutter boundary of the supercritical airfoil, which contrasts with the well-known behavior of the single transonic dip exhibited by conventional symmetric airfoils. Although the mechanism of the first dip at a lower Mach number corresponded to that of the well-known conventional transonic dip, the second dip at a higher Mach number was uniquely observed for the supercritical airfoil. The analysis established that, for the supercritical airfoil, the motion of the shock wave over the upper surface was significantly affected by the behavior of the boundary layer around the highly cambered aft region of the lower surface during flutter. The behavior of the boundary layer involving the separation and reattachment over the lower surface caused the unusual shock wave motion over the upper surface under the Mach number condition at the bottom of the second dip. This motion exerted negative damping forces on the motion of the airfoil, thereby becoming the primary contributor to generating the second dip experienced by the supercritical airfoil.
Thunderstruck! A quasicrystal made by lightning
Authors: Bindi Luca
Published: September 2023

A material with characteristics between crystal and glass has been accidentally created by an electrical discharge (likely a lightning strike) in the Sand Hills of Nebraska. The material is a quasicrystal with 12-fold symmetry, impossible for ordinary crystals. Transient high-pressure and high-temperature conditions seem to ease the formation of quasicrystals in nature.
Predictive Minisci and P450 Late Stage Functionalization with Transfer Learning
Authors: King-Smith Emma , Faber Felix A. , Reilly Usa , Sinitskiy Anton V. , Yang Qingyi , Liu Bo , Hyek Dennis , Lee Alpha A.
Published: September 2023

Structural diversification of lead molecules is a key component of drug discovery to explore chemical space. Late stage functionalizations (LSFs) are versatile methodologies capable of installing functional handles on richly decorated intermediates to deliver numerous diverse products in a single reaction. Predicting the regioselectivity of LSF is still an open challenge in the field. Numerous efforts from chemoinformatics and machine learning (ML) groups have made significant strides in this area. However, it is arduous to isolate and characterize the multitude of LSF products generated, limiting available data and hindering pure ML approaches. We report the development of an approach that combines a message passing neural network and 13C NMR-based transfer learning to predict the atom-wise probabilities of functionalization for Minisci and P450-based functionalizations. We validated our model both retrospectively and with a series of prospective experiments, showing that it accurately predicts the outcomes of Minisci-type and P450 transformations and outperforms the well-established Fukui-based reactivity indices and other machine learning reactivity-based algorithms.
Exploiting locality in FCIQMC for fast excitation generation
Authors: Weser Oskar , Alavi Ali , Li Manni Giovanni
Published: September 2023

In this paper we propose an improved excitation generation algorithm for the full configuration interaction quantum monte carlo (FCIQMC) method, which is particularly effective in systems described by localized orbitals. The method is an extension of the precomputed heat-bath (PCHB) strategy of Holmes et al., with more effective sampling of double excitations and a novel approach for non-uniform sampling of single excitations. We demonstrate the effectiveness of the algorithm for a chain of 30 hydrogen atoms with atom-localized orbitals, a stack of benzene molecules, an Fe-porphyrin model complex, whereby we show an overall efficiency gain by a factor of two to four, as measured by variance reduction per wall-clock time.
Data-driven development of an oral lipid-based nanoparticle formulation of a hydrophobic drug
Authors: Bao Zeqing , Yung Fion , Hickman Riley , Aspuru-Guzik Alán , Bannigan Pauric , Allen Christine
Published: September 2023

Due to its cost-effectiveness, convenience, and high patient adherence, oral drug administration often remains the preferred approach. Yet, the effective delivery of hydrophobic drugs via the oral route is often hindered by their limited water solubility and first-pass metabolism. To mitigate these challenges, advanced delivery systems such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been developed to encapsulate hydrophobic drugs and enhance their bioavailability. However, traditional design methodologies for these complex formulations often present intricate challenges because they are restricted to a relatively narrow design space. Here, we present a data-driven approach for the accelerated design of SLNs/NLCs encapsulating a model hydrophobic drug, cannabidiol, that combines experimental automation and machine learning. A small subset of formulations, comprising 10% of all formulations in the design space, was prepared in-house, leveraging miniaturized experimental automation to improve throughput and decrease the quantity of drug and materials required. Machine learning models were then trained on the data generated from these formulations and used to predict properties of all SLNs/NLCs within this design space (i.e., estimated to be more than 1200 formulations). Notably, formulations predicted to be high-performers via this approach were confirmed to significantly enhance the solubility of the drug by up to 3000-fold and prevent drug degradation. Moreover, our high-performance formulations significantly enhanced the oral bioavailability of the drug compared to both its free form and an over-the-counter version. Furthermore, this bioavailability matched that of a formulation equivalent in composition to the FDA-approved product, Epidiolex®.
NiGraf: A new nickel-based molecularly doped metal for enhanced water electrolysis
Authors: Pagliaro Mario , Pagliaro Maria V. , Caliandro Rocco , Giannini Cinzia , Ciriminna Rosaria , Lavacchi Alessandro
Published: September 2023

Graphene oxide was 3D entrapped in nickel nanoparticles and the resulting nanostructured material applied as electrocatalyst in both hydrogen and oxygen evolution reactions at room temperature. This establishes a completely new class of catalytic materials, dubbed herein “NiGraf”, which is highly promising towards enhanced alkaline water electrolysis.
Dynamic Lone Pairs and Fluoride-Ion Disorder in Cubic-BaSnF4
Authors: Mercadier Briséïs , Coles Samuel , Duttine Mathieu , Legein Christophe , Body Monique , Borkiewicz Olaf , Lebedev Oleg , Morgan Benjamin , Masquelier Christian , Dambournet Damien
Published: September 2023

Introducing compositional or structural disorder within crystalline solid electrolytes is a common strategy for increasing their ionic conductivity. (M,Sn)F2 fluorites have previously been proposed to exhibit two forms of disorder within their cationic host frameworks: occupational disorder from randomly distributed M and Sn cations, and orientational disorder from Sn(II) stereoactive lone pairs. Here, we characterise the structure and fluoride-ion–dynamics of cubic-BaSnF4, using a combination of experimental and computational techniques. Rietveld refinement of XRD data confirms an average fluorite structure with {Ba,Sn} cation disorder, and the 119Sn Mo ̈ssbauer spectrum demonstrates the presence of stereoactive Sn(II) lone pairs. X-ray total-scattering PDF analysis and ab initio molecular dynamics simulations reveal a complex local structure with a high degree of intrinsic fluoride-ion disorder, where 1/3 of fluoride ions occupy octahedral “interstitial” sites: this fluoride-ion disorder is a consequence of repulsion between Sn lone pairs and fluoride ions that destabilises Sn-coordinated tetrahedral fluoride-ion sites. Variable-temperature 19F NMR experiments and analysis of our molecular dynamics simulations reveal highly inhomogeneous fluoride-ion dynamics, with fluoride ions in Sn-rich local environments significantly more mobile than those in Ba-rich environments. Our simulations also reveal dynamical reorientation of the Sn lone pairs that is biased by the local cation configuration and is coupled to the local fluoride-ion dynamics. We end by discussing the effect of host-framework disorder on long-range diffusion pathways in cubic BaSnF4 .
Red-light-activatable "AND gated" antitumor immunosuppressant
Authors: Chen Xi , Zhou Ziqi , Zhang Yan , Xia Simin
Published: September 2023

Immunosuppressants are emerging as promising candidates for cancer therapy with lower cytotoxicity compared to traditional chemotherapy drugs; yet, the intrinsic side effects such as immunosuppression remain a critical concern. Herein, we introduce a photoactivatable antitumor immunosuppressant called dmBODIPY-FTY720 (BF) that shows no cytotoxicity but can be temporally and locally activated by deep-red light illumination to induce tumor cell apoptosis. To further reduce potential side effects, we integrate BF with another classic photosensitizer called methylene blue (MB) that is activated under the same wavelength of deep-red light (>650 nm), and successfully establish a red light activatable AND Boolean logic gate through a mechanism which we found to be synergetic apoptotic induction. At further decreased dosages, deep-red light illumination does not induce cell death in the presence of either BF or MB, but significant cancer cell death is triggered in the presence of both drugs. Therefore, the dosage of BF is further reduced which will be highly beneficial to minimize any potential side effects of BF. This AND gated strategy has been successfully applied in vivo for effective suppression of hepatocarcinoma tumor in living mice.
Open-ComBind: Harnessing unlabeled data for improved binding pose prediction
Authors: McNutt Andrew , Koes David
Published: September 2023

Determination of the bound pose of a ligand is a critical first step in many in silico drug discovery tasks. Molecular docking is the main tool for the prediction of non-covalent binding of a protein and ligand system. Molecular docking pipelines often only utilize the information of one ligand binding to the protein despite the commonly held hypothesis that different ligands share binding interactions when bound to the same receptor. Here we describe Open-ComBind, an easy-to-use, open-source version of the ComBind molecular docking pipeline that leverages information from multiple ligands without known bound structures to enhance pose selection. We first create distributions of feature similarities between ligand pose pairs, comparing near-native poses with all sampled docked poses. These distributions capture the likelihood of observing similar features, such as hydrogen bonds or hydrophobic contacts, in different pose configurations. These similarity distributions are then combined with a per-ligand docking score to enhance overall pose selection by 8.5% and 4.5% for high-affinity and congeneric series helper ligands, respectively. Open-ComBind reduces the average RMSD of ligands in our benchmark dataset by 8.2%. We provide Open-ComBind as an easy-to-use command line and Python API to increase pose prediction performance at www.github.com/drewnutt/open-combind.
Acercamiento a las eras de la historia del juego de mesa en España: Siglo XX
Authors: Catalán Antonio
Published: September 2023

El juego de mesa como fenómeno y producto cultural, no ha sido estudiado en España como en otros países de nuestro entorno y ha sido considerado como un producto accesorio del juguete, aunque es permanente en el tiempo, intergeneracional e intergénero. Utilizando los trabajos de autores como Whitehill y Brown, se definen una serie de etapas históricas en la producción y diseño de juegos a lo largo del siglo XX, identificando su evolución y sus principales productores, comparándola con su entorno, creando una división histórica para España. En ella se constata una historia dependiente de Alemania e Inglaterra en una primera etapa, con la copia y la falta de edición de la creatividad como una constante de todo el siglo. Borrás y Palouzié desde principios de siglo crearon un monopolio en el sector, a nivel de diseño, producción y distribución que encorsetó el mercado hasta los años 70, para seguir luego las tendencias de multinacionales como Parker, MB o Hasbro. La redefinición del juego de mesa, desde los años 80/90, no fue aprovechada por una parálisis y falta de visión del sector tradicional, no llegando a equipararse con el mercado mundial hasta los principios del siglo XXI, con la llegada del juego de mesa moderno a España
The Influence of Various Factors on MSME Halal Certification Behavior: An Analysis With Intention as an Intervening Variable
Authors: Pratikto Heri , Agustina Yuli , Kiranawati Titi Mutiara
Published: September 2023

Purpose: This research aims to conduct a comprehensive systematic literature review analyzing the impact of Self Declare on the Ease of Obtaining Halal Certification for Indonesian MSME.
 
Theoretical framework:  In recent years, the concept of Self Declare has emerged as a potential approach to ease the process of obtaining halal certification for MSMEs. Self Declare allows MSMEs to declare their products as halal based on their own understanding and compliance with halal requirements, reducing the bureaucratic burden and cost associated with traditional certification processes. However, the impact of Self Declare on the ease of obtaining halal certification and its implications for the halal industry in Indonesia require further investigation.
 
Design/methodology/approach: The study employs a quantitative research approach using the SEM-PLS method and the SmartPLS 3.0 software. The respondents of this study consist of MSME owners in Malang City .
 
Findings:   The findings reveal that halal awareness, halal literacy, perceptions of regulations, and halal certification behavioral intentions have a partial impact on the behavior of obtaining halal certification among MSMEs.  Furthermore, the intention to obtain halal certification mediates the relationship between halal awareness, halal literacy, and the behavior of obtaining halal certification among MSMEs. However, the intention to obtain halal certification does not moderate the relationship between halal literacy and the behavior of obtaining halal certification among MSMEs.
 
Research, Practical & Social implications: This research provides valuable insights for researchers, policymakers, and practitioners in the halal industry. The findings contribute to the existing knowledge on halal certification in MSME, while the practical and social implications offer actionable recommendations to enhance the ease of obtaining halal certification and promote the growth of the halal industry in Indonesia.
 
Originality/value: The originality and value of this research stem from its focus on Self Declare, comprehensive analysis, contextual relevance, exploration of mediating mechanisms, and practical implications. These aspects contribute to the advancement of knowledge in the field of halal certification in MSME and provide actionable insights for stakeholders in the industry.
Research on Ventilation and Heat Insulation Layer Design of Split-Type Roof Greening Based on Topological Interlocking Principle
Authors: Mingyu Jin  , Guoxu Hu  , Zichen Bai
Published: September 2023

In this paper, the roof ventilation and heat insulation layer modules are combined with the roof greening, and each module is assembled and combined through the principle of topological interlocking. The assembly of these modules does not require any rivets or cement mortar, and the structural stability of the overall assembled roof can be achieved only through the interlocking and limiting of the specific geometric shapes between the modules. Due to the modular design, this kind of green roof has strong applicability and can be applied to roofs of different shapes. Such a roof can not only meet the aesthetic needs, but also beautify the urban environment and reduce carbon emissions.
Application of BIM + VR Technology in Highway Design and Construction
Authors: Gong Tengfei
Published: September 2023

The application of building information modeling BIM and virtual reality VR has become increasingly popular in highway design and construction aiming to improve the efficiency and quality of design and construction. BIM and VR technology enable the digital management of expressway design and construction facilitating a visual interactive and immersive operational experience. Using a highway construction project as a case study this paper illustrates the specific application of BIM + VR technology in highway design and construction. This provides digital intelligent and efficient solutions for highway construction ultimately enhancing the quality and efficiency of the design and construction processes.
Research on Highway Bridge Inspection
Authors: Cao Jing , Chao Wang
Published: September 2023

Highway bridges are important transportation infrastructures in our country, and their quality is related to people's vital interests. Highway bridge detection, identification and test are the main means to evaluate the quality of highway bridges. Through the comprehensive application of various technologies, various quality problems of highway bridges can be found early, thereby ensuring traffic safety. This paper summarizes the role of highway bridge detection and test, summarizes the main content of highway bridge detection and test, analyzes and studies the problems and solutions in highway bridge detection and test, and lists examples to summarize experience, hoping to provide reference for relevant personnel.
PATIENT PERCEPTIONS OF SERVICE QUALITY IN THE DENTAL POLYCLINIC OF SUNAN KALIJAGA REGIONAL GENERAL HOSPITAL DEMAK: A STUDY ON BPJS AND NON-BPJS PATIENTS
Authors: Wardhana Erdianto Setya , Badriyah Nurul Laelatul
Published: September 2023

Background: The Social Security Organizing Agency (BPJS) is an initiative by the government to improve the quality of healthcare services. However, in reality, the services provided to BPJS patients have not yet reached optimal standards. The objective of this research is to identify patients' perceptions regarding the quality of services between BPJS and non-BPJS patients in the dental clinic of Sunan Kalijaga Regional General Hospital (RSUD) in Demak.Method: This research was conducted at the Dental Clinic of Sunan Kalijaga Regional General Hospital (RSUD) in Demak in the year 2020, using an observational analytical approach based on a cross-sectional design. The sample was selected using the slovin technique, with a total of 78 respondents divided into two groups, namely 39 respondents who were BPJS participants and 39 other respondents who were not BPJS participants.Result: The research results showed differences in SERVQUAL service quality scores between patients who were participants of BPJS and those who were not BPJS participants. Based on the analysis of both groups across the dimensions, reliability had gap scores of -0.7 and -0.9, tangible evidence had gap scores of -0.5 and -0.6, responsiveness had gap scores of -0.9 and -1, assurance had gap scores of -0.4 and -0.4, and empathy had gap scores of -0.4 and -1.1. These scores obtained a significance value (p<0.05),Conclusion: There were significant differences in patient perceptions between the quality of patient services for BPJS participants and non-BPJS patients.
Theoretical Study of Employment Issues
Authors: Hamid Ardiansyah , Indrayanti Kadek Wiwik , Wisnuwardhani Diah Aju
Published: September 2023

The problem raised in this research is regulating workers' rights and their protection in the Law. This study uses normative legal research methods with several approaches, namely the statutory and conceptual approaches. The results of this study state that the rights of workers/laborers are essential to implement because if workers and laborers are not given rights that are by human rights, then the work carried out by workers will not be able to run correctly. Whereas the contents of the manpower articles in the Law still have several normative problems, namely not yet providing guarantees of legal certainty for guarantees for the protection of workers' rights, such as determining proper wages and eligibility for severance pay. Likewise, with the provisions regarding layoffs, the Law only accommodates the interests of employers so that it can have implications for unilateral termination of employment relations with workers. The philosophical concept of Law is still co-opted with the liberal economic spirit, which is the fundamental basis for the birth of the Law, resulting in most people's rejection of the Law.How to cite item: Hamid, Ardiansyah, Kadek Wiwik Indrayanti, and Diah Aju Wisnuwardhani. “The Issue of Labor Law Versus Human Rights.” Jurnal Cakrawala Hukum 14 no. 1 (2023): 96-105. DOI: 10.26905/idjch.v14i1.9873.
Criminal Law Policies in an Effort to Tackle Criminal Acts of Terrorism Financing
Authors: Amrullah M. Arief
Published: September 2023

The issues that will be discussed in this research include what are. This research was initiated by the development of terrorist groups that request donations from individuals or groups or foundations, or corporations. Likewise, this writing aims to prevent the collection of funds to finance terrorist activities using corporations. Identifying Beneficial Owners of Corporations is very important in preventing criminal acts of terrorism financing. This article uses normative legal research methods. The sources of legal materials used are primary legal materials and secondary legal materials. The procedure for collecting legal materials in this article is to study library materials. Analysis of legal material sources was carried out descriptively. Empowering in its concretization, legal products related to terrorism funding need to be harmonized and renewed. Because of this, the existing law should be updated to suit developments and the modus operandi of terrorist organizations in raising funds so that the abuse of corporations as a vehicle for committing criminal acts of terrorism funding can be prevented and eradicated.How to cite item: Amrullah, M. Arief, “Legal Problems Related to Mineral and Coal Mining Permits.” Jurnal Cakrawala Hukum 14 no. 1 (2023): 86-95. DOI: 10.26905/idjch.v14i1.9881.
Legal Consequences of Notary Deeds Due to Comparison Error
Authors: Rimawati Elva Ria , Sulistyorini Rachmi , Laila Fathul
Published: September 2023

The purpose of writing this article is to analyze the accuracy carried out by a notary to minimize misuse of the submitted identity and prevent forgery. The notary's involvement in the event was questioned because of an error in the deed. Namely, being present before a notary is not actually present and giving false statements in an authentic deed containing a fake identity or signature. The method used is normative legal research. The results of the discussion contain analysis techniques as well as characteristics related to the nature of law and types of law. In conclusion, this authority is null and void or can be canceled due to the non-fulfillment of subjective requirements in statutory regulations. The legal consequences of a Notary Deed due to a comparative error have implications for the strength of the deed to be inauthentic because it is contrary to the terms and conditions determined by law.How to cite item: Rimawati, Elva Ria, Rachmi Sulistyorini, and Fathul Laila. “Legal Consequences of Notary Deeds Due to Comparison Error.” Jurnal Cakrawala Hukum. 14 no. 1 (2023): 1-8. DOI: 10.26905/idjch.v14i1.9906.
Ahlussunnah Wal Jama'ah Communication Forum is an Islamic Political Organizational Movement in Legal Studies
Authors: Nugraha Ridhoni Mirza , Sandhubaya Gilang
Published: September 2023

Indonesia's democratic transition post-reformation has changed the pattern of Indonesian politics. There were fluctuations and dynamics of Islamic political power during the New Order era. At the beginning of the New Order, Islam was marginalized from the state. Meanwhile, Islam encountered difficulties developing socio-political ideas because of the repressive New Order regime. It is interesting to note that although the majority of Indonesia's population is Muslim, nationalist political parties dominate every election. This article discusses complex unifying issues causing political turmoil: religion and the state. Much of Indonesia's current research on political Islam focuses on the rise of Islam-based political parties in domestic politics and the significant role of long-standing Islamic organizations such as Nahdlatul Ulama (NU) and Muhammadiyah. This topic is interesting to discuss because it is relatively new, discussing the fundamental issue, in this case, the problem of different understandings of the relationship between religion and the state. The research method used in this study is library research. Data obtained from literature research is used to understand the background, history, goals, and vision of FKAWJ and the political context of Islam in Indonesia.How to cite item: Nugraha, Ridhoni Mirza, and Gilang Sandhubaya. “Ahlussunnah Wal Jama'ah Communication Forum is an Islamic Political Organizational Movement in Legal Studies.” Jurnal Cakrawala Hukum 14 no. 2 (2023): 212-222. DOI: doi.org/10.26905/idjch.v14i2.10174.
Introduction
Authors: Palmisano Fabrizio , Rus Laurent
Published: September 2023

This chapter gives a brief overview on forensic structural engineering.
Point Pleasant ‘Silver’ Bridge
Authors: Polimeni Martín Eduardo
Published: September 2023

This chapter presents the forensic investigations of the collapse of the Point Pleasant Bridge. The collapse of this bridge has left important lessons learnt about, among other issues, the importance of the choice of the appropriate fracture-toughness steel to be used in bridges, the concept of structural redundancy, and the correct and systematic need for inspection and maintenance of existing bridges.

Likewise, it was the beginning of important modifications in the analysis of fracture and fatigue of steel bridges in the standards and codes.
Agrigento Cathedral: Landslide Assessment and Mitigation of the “Girgenti Hill”
Authors: Scuro Massimiliano , Mezzina Giuseppe , Venturini Simone , Rizzo Alessandro , Smorgon Pierpaolo
Published: September 2023

This chapter illustrates the studies carried out to interpret the landslide phenomenon that affected the hill where the Cathedral of Agrigento (Girgenti) and the entire diocesan area stand, producing subsidence of the bearing soil and damage to the superstructures of the buildings. The interpretation of the landslide phenomenon made it possible to rationally address the design of landslide risk mitigation interventions and, consequently, the execu-tion of structural consolidation works on the building.
Ibn Qutayba’s Approach to Solving the Semantic Ambiguitiesof the Holy Qurʾān: A Morphological Approach
Authors: Al-Kharrazi Nourdine
Published: September 2023

Objective: This study aims to identify Ibn Qutayba’s methodology in understanding the semantic ambiguities of the Holy Qurʾān, focusing on the morphological structure of its vocabulary. Methodology: The use of inductive, comparative, and deductive methods yielded significant scientific results that will be a valuable reference for researchers interested in understanding the intricacies of the language of the Holy Qurʾān. Results: The findings show that Ibn Qutaybah’s interpretive method can be a general model for understanding the Holy Qurʾān. Based as they were on the conventions of Arabic as the living language in which the Qurʾān was revealed and addressed itself to mankind, Ibn Qutayba’s interpretations gained wide acceptance among the interpreters in general. Originality: This study’s uniqueness lies in its specific focus on the intricacies of morphology as an obstacle to understanding the Qurʾān. No such research has been carried out to date. Ibn Qutayba’s approach constituted an essential model in this regard. Furthermore, the present study broadens the academic discussion by integrating perspectives from diverse commentators, thereby opening up new avenues for future inquiry in this field.
Abrogation (naskh) in Yūsuf b. Hilāl al-Ṣafadī’s (696 AH) Qurʾān commentary Kashf al-asrār wa-hatk al-astār
Authors: Freijat Salam Ahmad
Published: September 2023

Objective: This study aims to determine al-Ṣafadī’s position on the issue of abrogation (naskh) in the Holy Qurʾān and to present his textual and rational evidence for his position. Methodology: The study used an inductive approach for selecting relevant material from al-Ṣafadī’s Kashf al-asrār and an analytical method for examining his evidence and interpretations. Results: The study yielded several results: al-Ṣafadī believes that abrogation only applies to rulings found in texts antedating the Qurʾān by whose rulings they are replaced. Now even if al-Ṣafadī allows in principle for the abrogation of one Qurʾānic text by another, he finds its abrogation of rulings in other revealed books more relevant and appropriate. Originality: The scientific value of this study lies in the fact that al-Ṣafadī’s commentary on the Qurʾān is considered the first integral commentary to address the issue of abrogation from the perspective of those who reject its occurrence in the Qurʾān. This study may also be regarded as the first to address this issue in the Kashf al-Asrār.
Imām ʿAbd al-Ḥamīd b. Bādīs’ Stance towards Sufism
Authors: Belkheir Omrani
Published: September 2023

Objective: This article aims to clarify Imām ʿAbd al-Ḥamīd b. Bādīs’ stance towards Sufism. Researchers have varied opinions on classifying him as a Sufi or someone opposed to Sufism. Therefore, this article examines his upbringing, his interaction with the issues of his time, and his stance towards Sufism. Methodology: This study utilises a historical method to trace Ibn Bādīs’ opinions and stances within their historical contexts, an inductive method to infer his ideas through texts, an analytical method to analyse the texts, and a descriptive method to present his views from his perspective. Results: Ibn Bādīs had a Sufi upbringing, contributing significantly to his balanced views of Sufi issues. He distinguished between what is authentic and acceptable in Islam and what is foreign, which serves to discredit any assertions of his wholesale opposition to Sufism. Ibn Badis had his own approach to Sunni Sufism, as evident in his writings. Originality: The scientific value of this research lies in its revelation of the spiritual and Sufi dimensions of ʿAbd al-Ḥamīd b. Bādīs’ thought, opening the door for further studies on Sufism from his perspective.
A STUDY ON TRADITIONAL MOTIFS AND TECHNIQUES OF DHABHLA AND ITS CHANGES OF KUTCH REGION
Authors: Mogha Arooshi , Sharma Neeraj Rawat
Published: September 2023

The primary purpose of the study is to evaluate the traditional motifs and techniques of Dhabhla and its change in the Kutch region. Kutch district of Gujarat is a religious centre for pilgrimage and is interesting for historical lovers. The weaving craft of Kutch has its origins in the barter system in the past time. Weavers were very dependent upon other communities to get work. Traditional weaving has been accepted from generation to generation; the passage of time has created newness in design to retain its interest. The Dhabhla was available in various traditional motifs based on the daily life of the weavers - mostly geometrical motifs. The weaving of Kutch is famous for its traditional intricate designs, arrangement of motifs, and rural-based handicrafts. Usually, the effect of delicacy, rich-vivid, and contrast color combinations are imparted in patterning. The Centre of weaving is Kutch and Sunder Nagar.