bluuebunny/crossref_metadata_2025 huggingface dataset:
Plant Biostimulants Enhance Bud Break in Vitis vinifera Crimson Seedless Using Combination Treatments
Authors: Venter Nicole C. , Avenant Eunice , Kotze Theunis N. , Hills Paul N. , Moore John P.
Published: May 2024

The rest-breaking agent, hydrogen cyanamide (HC), can substitute insufficient chill unit accumulation in Vitis vinifera and induce uniform bud-break; however, due to its toxicity it is being banned. In South Africa, red seedless grapes, including V. vinifera Crimson Seedless (CS), are the largest table grape export group; therefore, replacing HC in V. vinifera CS is crucial. This study aimed to confirm the molecular triggers induced by HC and assess the bud-break-enhancing abilities of commercial plant biostimulants. Forced bud-break assay experiments using V. vinifera CS single-node cuttings and a small-scale field trial were performed. Results demonstrated that increased chill unit accumulation (CUA) reduced HC efficacy. Bud-break started between 10 and 20 days after treatment, irrespective of final CUA. The small-scale field trial found that HC 3% and biostimulants were similar to the negative control. The treatment of dormant grapevine compound buds with nitric oxide (NO), hydrogen peroxide (H2O2), and hypoxia trigger dormancy release to a certain extent, supporting the molecular models proposed for HC action. NO, H2O2, and hypoxia, in combination with PBs, may potentially replace HC; however, this needs to be confirmed in future experiments.
Assessing the Relationship between Physical Health, Mental Health and Students’ Success among Universities in Lebanon: A Cross-Sectional Study
Authors: Kharroubi Samer A. , Al-Akl Nayla , Chamate Sarah-Joe , Abou Omar Tarek , Ballout Rouba
Published: May 2024

Background: Achieving high academic success is known to be influenced by many factors including, but not limiting to, physical and mental health. The present study aimed to assess the relationship between physical health, mental health, and university students’ success, and to explore the associations between these factors and their academic achievement. Methods: A cross-sectional, self-administered online survey was used to collect data from college students in three different universities in Lebanon during the Fall 2023 semester. Mental health was evaluated using validated screening tools for depression, anxiety, and stress, specifically the Patient Health Questionnaire (PHQ-9), the General Anxiety Disorder (GAD-7), and Cohen’s Perceived Stress Scale (PSS), respectively. Additionally, general questions regarding physical health and lifestyle factors were incorporated into the questionnaire. Academic achievement was measured using students’ grade point average (GPA). Results: A total of 261 students completed the self-administered online survey. The results revealed that approximately 42% and 36% of students were experiencing moderate to severe symptoms of depression and anxiety, respectively, and 75.1% of students exhibited symptoms of moderate stress. The majority of participants (99.2%) did not report any physical disability. Chi-square analysis revealed a significant association between mental health status (depression, anxiety, and stress) and GPA level (p = 0.03, p = 0.044, p = 0.015, respectively). Multiple logistic regression models identified eight correlates of GPA and highlighted the relationship between physical health and student success. For instance, students who considered themselves moderately active had lower odds of achieving a higher GPA than those who considered themselves active (OR = 0.41, p = 0.045). Conclusions: This is the first investigation into Lebanese university students’ academic success in relation to lifestyle and mental health profiles. The findings indicate that implementing public health programs and interventions targeting mental health and lifestyle behaviors is essential for enhancing student success.
An Overview on Atopic Dermatitis, Oxidative Stress, and Psychological Stress: Possible Role of Nutraceuticals as an Additional Therapeutic Strategy
Authors: Alessandrello Clara , Sanfilippo Serena , Minciullo Paola L. , Gangemi Sebastiano
Published: May 2024

Atopic dermatitis (AD) is a chronic inflammatory skin condition with a considerable impact on patients’ quality of life. Its etiology is multifactorial and, among the predisposing factors, a role is played by oxidative stress. Pollution, recurrent infections, and psychological stress contribute to oxidative stress, amplifying the production of proinflammatory cytokines and worsening barrier damage. There are various oxidative stress mechanisms involved in the pathogenesis of AD. Moreover, AD often appears to be associated with psychological disorders such as alexithymia, depression, and anxiety due to severe itching and related insomnia, as well as social distress and isolation. The increasing incidence of AD requires the evaluation of additional therapeutic approaches in order to reduce the psychological burden of this condition. Our review aims to evaluate the role of some nutraceuticals in AD treatment and its related psychological comorbidities. The combination of some natural compounds (flavonoids, alkaloids, terpenes, isothiocyanates) with traditional AD treatments might be useful in improving the effectiveness of therapy, by reducing chronic inflammation and preventing flare-ups, and in promoting corticosteroid sparing. In addition, some of these nutraceuticals also appear to have a role in the treatment of psychological disorders, although the underlying oxidative stress mechanisms are different from those already known for AD.
Do Dominant Native Ants Outcompete the Invasive Argentine Ant in Mediterranean Citrus Ecosystems? A Laboratory Test
Authors: Zina Vera , Conde Sofia , Branco Manuela , Franco José Carlos
Published: May 2024

The invasive Argentine ant (Linepithema humile) poses a significant threat to ecosystem stability worldwide. In Mediterranean citrus ecosystems, its spread may be limited by interactions with dominant native ant species. We conducted laboratory experiments to investigate the competitive dynamics between Argentine ants and two major native species, Tapinoma nigerrimum and Lasius grandis. At the individual level, both native species exhibited superior competitive performance, attributed to their larger body sizes and potential differences in chemical defences. At the colony level, T. nigerrimum demonstrated efficiency in interference competition, successfully defending food resources from Argentine ants. However, the Argentine ant exhibited higher recruitment capacity, albeit it was density-dependent. Our findings support the hypothesis that dominant native ants can serve as barriers against Argentine ant invasion in citrus ecosystems, highlighting the importance of interspecific competition in shaping community dynamics and invasive species management. This study underscores the potential role of native ant species in mitigating the impacts of invasive ants on ecosystem functioning and biodiversity conservation in agricultural landscapes, offering valuable insights for invasive species management strategies in Mediterranean citrus ecosystems.
Satellite Thermal Management Pump Impeller Design and Optimization
Authors: Drăgan Valeriu , Dumitrescu Oana , Dobromirescu Cristian , Popa Ionuț Florian
Published: May 2024

This study presents a numerical approach to the design and optimization of centrifugal impellers used in the pumps of active thermal control systems of spacecraft. Although launch costs have shrunk in the last decade, the performance requirements, such as efficiency and reliability, have increased, as such systems are required to work up to 15 years, depending on the mission. To that effect, our paper deals with the first step in this pump design, namely the hydraulic optimization of the impeller. Constructively, this type of impeller allows for certain balancing systems and labyrinth seals to be applied in a more effective way, as well as allowing for additive manufacturing methods to be used—however, details regarding these aspects are beyond the scope of the current paper. By combining empirical formulas, computational fluid dynamics (CFD) analysis, and artificial neural networks (ANNs), the research focuses on achieving high efficiency and fast manufacturing. A series of geometries have been sized and validated using steady-state RANS (Reynolds Averaged Navier-Stokes) simulations, leading to the identification of the most efficient configuration. Subsequent optimization using an ANN resulted in a refined impeller design with notable improvements in hydraulic performance: a 3.55% increase in efficiency and a 7.9% increase in head. Key parameters influencing impeller performance, including blade number, incidence, and backsweep angles, are identified. This approach offers a comprehensive method to address the evolving requirements of space missions and contributes to the advancement of centrifugal pump technology in the space domain.
Condition Monitoring in Additive Manufacturing: A Critical Review of Different Approaches
Authors: Khanafer Khalil , Cao Junqian , Kokash Hussein
Published: May 2024

This critical review provides a comprehensive analysis of various condition monitoring techniques pivotal in additive manufacturing (AM) processes. The reliability and quality of AM components are contingent upon the precise control of numerous parameters and the timely detection of potential defects, such as lamination, cracks, and porosity. This paper emphasizes the significance of in situ monitoring systems—optical, thermal, and acoustic—which continuously evaluate the integrity of the manufacturing process. Optical techniques employing high-speed cameras and laser scanners provide real-time, non-contact assessments of the AM process, facilitating the early detection of layer misalignment and surface anomalies. Simultaneously, thermal imaging techniques, such as infrared sensing, play a crucial role in monitoring complex thermal gradients, contributing to defect detection and process control. Acoustic monitoring methods augmented by advancements in audio analysis and machine learning offer cost-effective solutions for discerning the acoustic signatures of AM machinery amidst variable operational conditions. Finally, machine learning is considered an efficient technique for data processing and has shown great promise in feature extraction.
Development of Multi-Part Field-Shapers for Magnetic Pulse Welding Using Nanostructured Cu-Nb Composite
Authors: Zaytsev Evgeny , Krutikov Vasiliy , Spirin Alexey , Paranin Sergey
Published: May 2024

Magnetic pulse welding (MPW) employs a strong pulsed magnetic field to accelerate parts against each other, thus forming an impact joint. Single-turn tool coils and field-shapers (FSs) used in MPW operate under the most demanding conditions, such as magnetic fields of 40–50 T with periods lasting tens of microseconds. With the use of conventional copper and bronze coils, intense thermo-mechanical stresses lead to the rapid degradation of the working bore. This work aimed to improve the efficiency of field-shapers and focused on the development of two- and four-slit FSs with a nanocomposite Cu 18Nb brazed wire acting as an inner current-carrying layer. The measured ratios of the magnetic field to the discharge current were 56.3 and 50.6 T/MA for the two- and four-slit FSs, respectively. FEM calculations of the magnetic field generated showed variations of 6–9% and 3% for the two- and four-slit FSs, respectively. The ovality percentages following copper tube compression were 27% and 7% for the two- and four-slit FSs, respectively. The measured deviations in the weld-joining length were 11% and 1.4% in the two- and four-slit FSs, respectively. Compared to the previous experiments on an entirely steel inductor, the novel FS showed significantly better results in terms of its efficiency and the homogeneity of its magnetic field.
Identification and Pathogenicity of Fusarium Species Associated with Onion Basal Rot in the Moscow Region of Russian Federation
Authors: Vetrova Svetlana , Alyokhina Ksenia , Engalycheva Irina , Kozar Elena , Mukhina Kseniya , Sletova Maria , Krivenkov Leonid , Tikhonova Tatyana , Kameneva Alina , Frolova Svetlana , Chizhik Vera , Martynov Viktor
Published: May 2024

Fusarium basal rot of onions causes large losses during storage of commercial production of onion bulbs, which in turn adversely affects the food market situation in the off-season period. There are no data on the composition of Fusarium spp., which causes onion basal rot in the Russian Federation. Therefore, our research was aimed at Fusarium spp. causing onion basal rot in the Moscow Region of the Russian Federation and studying the pathogenicity of these species for the host plant. We studied 20 isolates of Fusarium spp. collected from affected mature bulbs and seed bulbs. Species identification of the isolates was carried out using analysis of the nucleotide sequences of the three genetic loci ITS, tef1 and rpb2, as well as was based on the macro- and micromorphological characteristics of these isolates. As a result, the species F. annulatum (F. fujikuroi species complex), F. oxysporum (F. oxysporum species complex), F. acuminatum (F. tricinctum species complex) and F. solani (F. solani species complex) were identified to involve in the pathogenesis of Fusarium basal rot. We have shown for the first time that the species F. annulatum and F. acuminatum are highly aggressive and capable of causing onion basal rot. The predominant species were F. annulatum and F. oxysporum. The proportion of these species in the total number of analyzed isolates was 60% and 25%, respectively. The largest proportion (33%) of highly aggressive on mature bulbs isolates was found in the species F. annulatum. The data obtained provide practical insights for developing strategies to manage Fusarium fungi responsible for onion basal rot Moscow Region of the Russian Federation. In addition, data about species composition and aggressive isolates may be used in onion breeding for resistance to Fusarium basal rot.
Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows
Authors: Argüelles Juan Carlos , Sánchez-Fresneda Ruth , Argüelles Alejandra , Solano Francisco
Published: May 2024

Fungi are eukaryotic organisms with relatively few pathogenic members dangerous for humans, usually acting as opportunistic infections. In the last decades, several life-threatening fungal infections have risen mostly associated with the worldwide extension of chronic diseases and immunosuppression. The available antifungal therapies cannot combat this challenge because the arsenal of compounds is scarce and displays low selective action, significant adverse effects, and increasing resistance. A growing isolation of outbreaks triggered by fungal species formerly considered innocuous is being recorded. From ancient times, natural substances harvested from plants have been applied to folk medicine and some of them recently emerged as promising antifungals. The most used are briefly revised herein. Combinations of chemotherapeutic drugs with natural products to obtain more efficient and gentle treatments are also revised. Nevertheless, considerable research work is still necessary before their clinical use can be generally accepted. Many natural products have a highly complex chemical composition, with the active principles still partially unknown. Here, we survey the field underlying lights and shadows of both groups. More studies involving clinical strains are necessary, but we illustrate this matter by discussing the potential clinical applications of combined carnosic acid plus propolis formulations.
Chronic Pulmonary Aspergillosis after Surgical Treatment for Non-Small Cell Lung Cancer—An Analysis of Risk Factors and Clinical Outcomes
Authors: Whittaker George , Taylor Marcus , Chamula Mathilde , Granato Felice , Balata Haval , Kosmidis Chris
Published: May 2024

Chronic pulmonary aspergillosis (CPA) is a rare but significant complication of lung cancer surgery. Its effect on survival remains unclear. Our aim was to describe the outcomes of the patients who developed CPA following the surgery for non-small cell lung cancer (NSCLC), identify the risk factors associated with its development following lung resection, and evaluate its impact on survival. All the patients with a diagnosis of CPA and operated NSCLC were identified in the National Aspergillosis Centre (NAC) database (2009–2020). Additional patients were identified in the Northwest Clinical Outcomes Research Registry (2012–2019) database. A regression analysis was performed to examine potential links between CPA and long-term outcomes and also to identify the factors associated with the development of CPA. The primary outcomes were the development of CPA, 1-year and 5-year mortality, and overall survival. Thirty-two patients diagnosed with CPA after lung resection were identified in the NAC database, of which 11 were also contained within the NCORR database, with a prevalence of 0.2% (n = 11/4425). Post-operative CPA was associated with significantly lower survival on log-rank analysis (p = 0.020). Mortality at one year was 25.0% (n = 8) and 59.4% (n = 19) at five years after the CPA diagnosis. On univariable analysis, a lower mean percentage-predicted forced expiratory volume in 1 s, ischaemic heart disease, and chronic obstructive pulmonary disease were all significantly associated with CPA development. CPA is a rare complication following lung cancer surgery which has a significant impact on long-term survival. Its development may be associated with pre-existing cardiopulmonary comorbidities. Further research in larger cohorts is required to substantiate these findings.
Styling Authenticity in Country Music
Authors: Werner Valentin , Ledermann Anna
Published: May 2024

Country music has become commercially successful both in the US and worldwide. It is perceived as a genre that values authenticity, which may be reflected in the choice of linguistic features, with (White) Southern American English (SAE) serving as the “default” variety. Given the recent diversification of the genre, the question arises whether the use of SAE features is still considered obligatory as a kind of “supralocal norm”. This study compared the lyrics of 600 highly successful songs by male and female artists from White Southern, Black Southern, and White non-Southern backgrounds. The aim was to test (i) whether morphosyntactic SAE features are used to index authenticity in the sense of having become enregistered for this music genre and (ii) whether non-Southerners engage in the styling of relevant markers. It emerged that non-Southerners use more of these features than their Southern counterparts, providing preliminary evidence for “genre fitting” as a means of indexing authenticity. However, there is only one marker that qualifies as a core Country feature used across all artist groups, namely negative concord. As this item arguably is better categorized as vernacular universal, SAE morphosyntax appears to have largely lost its indexical function in Country, while accent features are still vital to establishing cultural authenticity.
Study on the Vibration Characteristics of the Helical Gear-Rotor-Bearing Coupling System of a Wind Turbine with Composite Faults
Authors: Zhang Hongyuan , Li Shuo , Sun Hongyun
Published: May 2024

As the core component of the wind turbine generation gearbox, the gear-rotor-bearing transmission system typically operates in harsh environments, inevitably leading to the occurrence of composite faults in the system, which exacerbates system vibration. Therefore, it is necessary to study the vibration characteristics of wind turbine helical gear-rotor-bearing transmission systems with composite faults. This paper uses an improved energy method to calculate the theoretical time-varying mesh stiffness of a helical gear with a root crack failure. On the premise of considering the time-varying meshing stiffness of the faulty helical gear, the gear eccentric fault, and the nonlinear support force of the faulty bearing, a multi-degree-of-freedom helical gear-rotor-bearing transmission system with compound faults was established by using the lumped parameter method. The dynamic model of the system was solved based on the Runge–Kutta method, and the vibration response of the system under healthy conditions, single faults with gear eccentricity, single faults with tooth root cracks, and coupled bearing composite faults were simulated and analyzed. The results show that the simulation results based on KISSsoft software 2018 version verify the effectiveness of the improved energy method; the existence of single faults and composite faults will cause the fault characteristics in the time domain and frequency domain responses. In this paper, the influence of a single fault and a complex fault on the time domain and frequency domain of the system is mainly discovered through the fault study of the helical rotor-bearing system, and the influence of the fault degree on the vibration of the gear motion system is discussed. The greater the degree of the fault, the more vibration of the system occurs; accordingly, when the system is under the coupling of tooth root crack and bearing fault, there is a significant difference compared with the healthy system and the single fault system. The system vibration has obvious time domain and frequency domain signal characteristics, including periodic pulse impacts caused by gear faults and time domain impact caused by bearing. The fault characteristic frequencies can also be found in the frequency domain. In this paper, the fault study of a helical gear of wind turbine generation provides a reference for the theoretical analysis of the vibration characteristics of the helical gear-rotor-bearing system under various fault conditions, lays a solid foundation for the simulation and subsequent diagnosis of the composite fault signal of the system, and provides help for the fault diagnosis of wind turbine gearboxes in the future.
The Association of Epileptic Seizures after Acute Ischemic Stroke with Cerebral Cortical Involvement and Electroencephalographic Changes
Authors: Šmigelskytė Agnė , Rimkuvienė Gabija , Žukaitė Dominyka , Repečkaitė Gerta , Jurkevičienė Giedrė
Published: May 2024

Background and objectives: while acute ischemic stroke is the leading cause of epilepsy in the elderly population, data about its risk factors have been conflicting. Therefore, the aim of our study is to determine the association of early and late epileptic seizures after acute ischemic stroke with cerebral cortical involvement and electroencephalographic changes. Materials and methods: a prospective cohort study in the Hospital of the Lithuanian University of Health Sciences Kaunas Clinics Department of Neurology was conducted and enrolled 376 acute ischemic stroke patients. Data about the demographical, clinical, radiological, and encephalographic changes was gathered. Patients were followed for 1 year after stroke and assessed for late ES. Results: the incidence of ES was 4.5%, the incidence of early ES was 2.7% and the incidence of late ES was 2.4%. The occurrence of early ES increased the probability of developing late ES. There was no association between acute cerebral cortical damage and the occurrence of ES, including both early and late ES. However, interictal epileptiform discharges were associated with the occurrence of ES, including both early and late ES.
The Effects of Si Substitution with C on the Amorphous Forming Ability, Thermal Stability, and Magnetic Properties of an FeSiBPC Amorphous Alloy
Authors: Zhu Wenzhong , Jiang Xiaoqian , Chen Chen , Wu Shaojie , Cai Yongfu , Li Fushan , Wei Ran , Wang Tan
Published: May 2024

The industrialization of Fe-based amorphous alloys with high a saturation magnetic flux density (Bs) has been limited so far due to their inadequate amorphous forming ability (AFA). In this study, the effects of substituting Si with C on the AFA, thermal stability, and magnetic properties of Fe82Si6−xB9P3Cx (x = 0–6) alloys were systematically investigated. The experimental results demonstrate that the AFA, thermal stability, and soft magnetic properties can be significantly enhanced by the addition of C. Specifically, at a copper wheel velocity of 40 m/s, the Fe82Si6−xB9P3Cx (x = 2, 3, 4, 5 and 6) alloy ribbons exhibit a fully amorphous structure in the as-spun state. The activation energy required for the α-Fe phase crystallization process in Fe82Si6−xB9P3Cx (x = 0, 2, 4, and 6) alloys is determined to be 326.74, 390.69, 441.06, and 183.87 kJ/mol, respectively. Among all of the compositions studied, the Fe82Si4B9P3C2 alloy exhibits optimized soft magnetic properties, including a low coercivity (Hc) of 1.7 A/m, a high effective permeability (μe) of 10608 (f = 1 kHz), and a relatively high Bs of 1.61 T. These improvements may be attributed to a more homogeneous and optimized magnetic domain structure being achieved through proper C addition. This work holds significant implications for the advancement of Fe-based soft magnetic amorphous alloys with high Bs.
Structure Design and Heat Transfer Performance Analysis of a Novel Composite Phase Change Active Cooling Channel Wall for Hypersonic Aircraft
Authors: Li Weichen , Zhao Jieliang , Wu Xiangbing , Liang Lulu , Wang Wenzhong , Yan Shaoze
Published: May 2024

Efficient and stable heat dissipation structure is crucial for improving the convective heat transfer performance of thermal protection systems (TPSs) for hypersonic aircraft. However, the heat dissipation wall of the current TPS is limited by a single material and structure, inefficiently dissipating the large amount of accumulated heat generated during the high-speed maneuvering flight of hypersonic aircraft. Here, a convection cooling channel structure of TPS is proposed, which is an innovative multi-level structure inspired by the natural honeycomb. An active cooling channel (PCM-HC) is designed by using a variable-density topology optimization method and filled with phase change material (PCM). Numerical simulations are used to investigate the thermal performance of the PCM-HC wall, focusing on the influence of PCM properties, structural geometric parameters, and PCM types on heat transfer characteristics. The results demonstrate that the honeycomb-like convection cooling channel wall, combined with PCM latent heat of phase change, exhibits superior heat dissipation capability. With a heat flux input of 50 kW/m2, the maximum temperature on the inner wall of PCM-HC is reduced by 12 K to 20 K. Different PCMs have opposing effects on heat transfer performance due to their distinct thermophysical properties. This work can provide a theoretical basis for the design of high-efficiency cooling channel, improving the heat dissipation performance in the TPS of hypersonic aircraft.
Mineralogical Constraints on the Pressure–Temperature Evolution of Granulites in the Bunger Hills, East Antarctica
Authors: Abdrakhmanov Ilnur A. , Gulbin Yuri L. , Skublov Sergey G. , Galankina Olga L.
Published: May 2024

Spinel- and orthopyroxene-bearing metapelitic granulites exposed in the Bunger Hills, East Antarctica, have been intensively studied in recent years because they are supposed to record evidence for UHT metamorphism. Detailed petrographic observations, as well as whole rock and mineral chemistry, together with SIMS trace element data on quartz, garnet, and orthopyroxene, are presented for these rocks. Mineral thermobarometry, including Al-in-orthopyroxene, ternary feldspar, Ti-in-quartz, and Fe-Ti oxide solvus, has been used to quantify the UHT conditions. Based on phase equilibrium modeling, a tight clockwise P-T path has been deduced, which involves near-isobaric heating at 6–7 kbar to ~950 °C followed by near-isobaric to slightly up-pressure cooling at 5–6 kbar to ~750 °C. It is concluded that the outlined metamorphic history is characteristic of an extensional crustal regime which is also evidenced by the correlation of prograde and retrograde metamorphism with the extensional and compressional phases of major ductile deformations recognized in the region. In order to constrain the tectonic setting of the granulites, this result is discussed in the context of current views on the Mesoproterozoic evolution of the Albany-Fraser Orogen, the westernmost part of which the Bunger Hills are considered to be.
3D Modelling Approach to Enhance the Characterization of a Bronze Age Nuragic Site
Authors: Cara Stefano , Valera Paolo , Matzuzzi Carlo
Published: May 2024

Megalithism in Sardinia (Italy) had its highest expression during the Bronze Age with the creation of monumental complexes known as Nuraghes. These unique monuments have recently been the subject of in-depth investigations for their potential to be recognized as World Heritage Sites (by UNESCO). The main purpose of our research was to make a contribution to obtain a more in-depth characterization of these monuments by testing a 3D model of a complex Nuraghe, integrated with an analysis of the geolithological context. This work first focused on the geological and typological investigation of the materials used in its construction, which was then compared with the geolithological characteristics of the region. A survey of the outcropping remains was carried out by means of Structure-from-Motion Multi-View Stereo (SfM-MVS) photogrammetry with UAV ground and aerial acquisition using APS-C photo sensors, georeferenced with an RTK-GNSS ground survey. The level of accuracy of our digital models shows the potential of the proposed method, giving accurate and geometrically consistent 3D reconstructions in terms of georeferencing error, shape and surface. The survey method allows for the virtualization of the current state of conservation of the Nuraghe, giving a solid basis to set up further (future) archaeological excavations and to contribute to knowledge on the architecture of the structures. This study also provides useful information on the nature and origin of the construction materials and proposes a hypothesis on the original dimensions of the monument, which is often a topic of debate in the world of archaeology.
Potential Utilization of Loess in Grouting Materials: Effects of Grinding Time and Calcination Temperature
Authors: Bai Hao , Wang Kai , Zhang Xiaoqiang , Jiang Yulong , Zhang Shiyu
Published: May 2024

There is a huge reservation of loess in the Shanxi mining area in China, which has great potential for preparing supplementary cementitious materials. Loess was modified via mechanical and thermal activation, and the pozzolanic activity was evaluated using an Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). Moreover, the workability of grouting materials prepared using modified loess was assessed. The experimental results revealed that the number of ultrafine particles gradually increased with the grinding time, enhancing the grouting performance. The coordination number of Al decreased upon the breakage of the Al–O–Si bond post-calcination at 400 °C, 550 °C, 700 °C, and 850 °C. Moreover, the breaking of the Si–O covalent bond produced Si-phases, and the pozzolanic activity of loess increased. Furthermore, the modified loess was hydrated with different cement proportions. With increasing grinding time, the overall setting time increased until the longest time of 14.5 h and the fluidity of the slurry decreased until the lowest fluidity of 9.7 cm. However, the fluidity and setting time decreased with increasing calcination temperature. The lowest values were 12.03 cm and 10.05 h. With the increase in pozzolanic activity, more ettringite was produced via hydration, which enhanced the mechanical properties. The maximum strength of the hydrated loess after grinding for 20 min reached 16.5 MPa. The strength of the hydrated loess calcined at 850 °C reached 21 MPa. These experimental findings provide theoretical support for the practical application of loess in grouting.
Deposition of Pd, Pt, and PdPt Nanoparticles on TiO2 Powder Using Supercritical Fluid Reactive Deposition: Application in the Direct Synthesis of H2O2
Authors: Crone Marlene , Trinkies Laura L. , Dittmeyer Roland , Türk Michael
Published: May 2024

In this study, we investigated the catalytic properties of mono- and bimetallic palladium (Pd) and platinum (Pt) nanoparticles deposited via supercritical fluid reactive deposition (SFRD) on titanium dioxide (TiO2) powder. Transmission electron microscopy analyses verified that SFRD experiments performed at 353 K and 15.6 MPa enabled the deposition of uniform mono- and bimetallic nanoparticles smaller than 3 nm on TiO2. Electron-dispersive X-ray spectroscopy demonstrated the formation of alloy-type structures for the bimetallic PdPt nanoparticles. H2O2 is an excellent oxidizing reagent for the production of fine and bulk chemicals. However, until today, the design and preparation of catalysts with high H2O2 selectivity and productivity remain a great challenge. The focus of this study was on answering the questions of (a) whether the catalysts produced are suitable for the direct synthesis of hydrogen peroxide (H2O2) in the liquid phase and (b) how the metal type affects the catalytic properties. It was found that the metal type (Pd or Pt) influenced the catalytic performance strongly; the mean productivity of the mono- and bimetallic catalysts decreased in the following order: Pd > PdPt > Pt. Furthermore, all catalysts prepared by SFRD showed a significantly higher mean productivity compared to the catalyst prepared by incipient wetness impregnation.
Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry
Authors: Wroński Michał , Trawiński Jakub , Skibiński Robert
Published: May 2024

The main objective of this study was to investigate the metabolism of miconazole, an azole antifungal drug. Miconazole was subjected to incubation with human liver microsomes (HLM) to mimic phase I metabolism reactions for the first time. Employing a combination of an HLM assay and UHPLC-HRMS analysis enabled the identification of seven metabolites of miconazole, undescribed so far. Throughout the incubation with HLM, miconazole underwent biotransformation reactions including hydroxylation of the benzene ring and oxidation of the imidazole moiety, along with its subsequent degradation. Additionally, based on the obtained results, screen-printed electrodes (SPEs) were optimized to simulate the same biotransformation reactions, by the use of a simple, fast, and cheap electrochemical method. The potential toxicity of the identified metabolites was assessed using various in silico models.
BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms
Authors: Bolat Ecem , Eker Furkan , Yılmaz Selin , Karav Sercan , Oz Emel , Brennan Charles , Proestos Charalampos , Zeng Maomao , Oz Fatih
Published: May 2024

Bovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk. Among these, β-casein comprises around 37% of all caseins, and it is an important type of casein with several different variants. The A1 and A2 variants of β-casein are the most researched genotypes due to the changes in their composition. It is accepted that the A2 variant is ancestral, while a point mutation in the 67th amino acid created the A1 variant. The digestion derived of both A1 and A2 milk is BCM-7. Digestion of A2 milk in the human intestine also forms BCM-9 peptide molecule. The opioid-like characteristics of BCM-7 are highlighted for their potential triggering effect on several diseases. Most research has been focused on gastrointestinal-related diseases; however other metabolic and nervous system-based diseases are also potentially triggered. By manipulating the mechanisms of these diseases, BCM-7 can induce certain situations, such as conformational changes, reduction in protein activity, and the creation of undesired activity in the biological system. Furthermore, the genotype of casein can also play a role in bone health, such as altering fracture rates, and calcium contents can change the characteristics of dietary products. The context between opioid molecules and BCM-7 points to a potential triggering mechanism for the central nervous system and other metabolic diseases discussed.
A 4D-Printable Photocurable Resin Derived from Waste Cooking Oil with Enhanced Tensile Strength
Authors: Liu Yan , Liu Meng-Yu , Fan Xin-Gang , Wang Peng-Yu , Chen Shuo-Ping
Published: May 2024

In pursuit of enhancing the mechanical properties, especially the tensile strength, of 4D-printable consumables derived from waste cooking oil (WCO), we initiated the production of acrylate-modified WCO, which encompasses epoxy waste oil methacrylate (EWOMA) and epoxy waste oil acrylate (EWOA). Subsequently, a series of WCO-based 4D-printable photocurable resins were obtained by introducing a suitable diacrylate molecule as the second monomer, coupled with a composite photoinitiator system comprising Irgacure 819 and p-dimethylaminobenzaldehyde (DMAB). These materials were amenable to molding using an LCD light-curing 3D printer. Our findings underscored the pivotal role of triethylene glycol dimethacrylate (TEGDMA) among the array of diacrylate molecules in enhancing the mechanical properties of WCO-based 4D-printable resins. Notably, the 4D-printable material, composed of EWOA and TEGDMA in an equal mass ratio, exhibited nice mechanical strength comparable to that of mainstream petroleum-based 4D-printable materials, boasting a tensile strength of 9.17 MPa and an elongation at break of 15.39%. These figures significantly outperformed the mechanical characteristics of pure EWOA or TEGDMA resins. Furthermore, the EWOA-TEGDMA resin demonstrated impressive thermally induced shape memory performance, enabling deformation and recovery at room temperature and retaining its shape at −60 °C. This resin also demonstrated favorable biodegradability, with an 8.34% weight loss after 45 days of soil degradation. As a result, this 4D-printable photocurable resin derived from WCO holds immense potential for the creation of a wide spectrum of high-performance intelligent devices, brackets, mold, folding structures, and personalized products.
A Protocol for Comprehensive Analysis of Gait in Individuals with Incomplete Spinal Cord Injury
Authors: Butler Forslund Emelie , Truong Minh Tat Nhat , Wang Ruoli , Seiger Åke , Gutierrez-Farewik Elena M.
Published: May 2024

This is a protocol for comprehensive analysis of gait and affecting factors in individuals with incomplete paraplegia due to spinal cord injury (SCI). A SCI is a devastating event affecting both sensory and motor functions. Due to better care, the SCI population is changing, with a greater proportion retaining impaired ambulatory function. Optimizing ambulatory function after SCI remains challenging. To investigate factors influencing optimal ambulation, a multi-professional research project was grounded with expertise from clinical rehabilitation, neurophysiology, and biomechanical engineering from Karolinska Institutet, the Spinalis Unit at Aleris Rehab Station (Sweden’s largest center for specialized neurorehabilitation), and the Promobilia MoveAbility Lab at KTH Royal Institute of Technology. Ambulatory adults with paraplegia will be consecutively invited to participate. Muscle strength, sensitivity, and spasticity will be assessed, and energy expenditure, 3D movements, and muscle function (EMG) during gait and submaximal contractions will be analyzed. Innovative computational modeling and data-driven analyses will be performed, including the identification of clusters of similar movement patterns among the heterogeneous population and analyses that study the link between complex sensorimotor function and movement performance. These results may help optimize ambulatory function for persons with SCI and decrease the risk of secondary conditions during gait with a life-long perspective.
Use of Digital Tools for the Assessment of Food Consumption in Brazil: A Scoping Review
Authors: Silva Adriane dos Santos da , Brito Flávia dos Santos Barbosa , Santos Debora Martins dos , Adegboye Amanda Rodrigues Amorim
Published: May 2024

This is a scoping review on mapping the use of digital tools to assess food consumption in Brazil. Searches were carried out in nine electronic databases (Medline, Lilacs, Scopus, Embase, Web of Science, Science Direct, Ovid, Free Medical Journal and Crossref) to select studies published from October 2020 to December 2023. This review identified forty-eight digital tools in the 94 publications analyzed, the most frequent being web-based technologies (60%) and mobile devices (40%). Among these studies, 55% (n = 52) adopted a population-based approach, while 45% (n = 42) focused on specific regions. The predominant study design observed was cross-sectional (n = 63). A notable trend observed was the increasing frequency of validation studies in recent years. Although the use of digital tools in the assessment of food consumption in Brazil has grown in recent years, studies did not describe the process of creating and validating the tools, which would contribute to the improvement of data quality. Investments that allow the expansion of the use of the internet and mobile devices; the improvement of digital literacy; and the development of open-access tools, especially in the North and Northeast regions, are challenges that require a concerted effort towards providing equal opportunities, fostering encouragement, and delving deeper into the potential of digital tools within studies pertaining to food consumption in Brazil.
Adolescents Identify Modifiable Community-Level Barriers to Accessing Mental Health and Addiction Services in a Rural Canadian Town: A Survey Study
Authors: Marmura Hana , Cozzi Regina R. F. , Blackburn Heather , Ortiz-Alvarez Oliva
Published: May 2024

Adolescents are particularly vulnerable to inadequate provision of mental health and addictions care, as services have been traditionally conceptualized to serve the needs of children or adults. Additionally, rural communities have been largely excluded from research investigating mental healthcare access and exhibit unique barriers that warrant targeted interventions. Finally, perspectives from the target population will be most important when understanding how to optimize adolescent mental health and addictions care. Therefore, the purpose of this study was to identify what adolescents in a rural town perceive as barriers to accessing mental health services. We conducted a cross-sectional survey study with high school students to generate ranked lists of the top perceived individual-level, community-level, and overall barriers. A total of 243 high school students responded to the survey. Perceived barriers were predominantly at the community level. Overall, the top barriers reported were a lack of awareness and education regarding mental health, resources, and the nature of treatment. Students who had previously accessed mental health services identified primary barriers related to mental health professionals, whereas students who had not accessed care reported fear and uncertainty as primary barriers. Modifiable community-level factors related to (1) mental health literacy and (2) mental healthcare professionals were identified by adolescents as the main perceived barriers to accessing mental health and addiction services in a rural town. The findings of this preliminary study should inform intervention strategies and further rigorous research for this traditionally underserved target population.
Change in Neurocognitive Function in Patients Who Receive CAR-T Cell Therapies: A Steep Hill to Climb
Authors: Strongyli Evlampia , Evangelidis Paschalis , Sakellari Ioanna , Gavriilaki Maria , Gavriilaki Eleni
Published: May 2024

Immunotherapy with chimeric antigen receptor T (CAR-T) cell therapies has brought substantial improvement in clinical outcomes in patients with relapsed/refractory B cell neoplasms. However, complications such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) limit the therapeutic efficacy of this treatment approach. ICANS can have a broad range of clinical manifestations, while various scoring systems have been developed for its grading. Cognitive decline is prevalent in CAR-T therapy recipients including impaired attention, difficulty in item naming, and writing, agraphia, and executive dysfunction. In this review, we aim to present the diagnostic methods and tests that have been used for the recognition of cognitive impairment in these patients. Moreover, up-to-date data about the duration of cognitive impairment symptoms after the infusion are presented. More research on the risk factors, pathogenesis, preventive measures, and therapy of neurocognitive impairment is crucial for better outcomes for our patients.
Global Receptive Field Designed Complex-Valued Convolutional Neural Network Equalizer for Optical Fiber Communications
Authors: Han Lu , Wang Yongjun , Yang Haifeng , Zhao Yang , Li Chao
Published: May 2024

In this paper, an improved complex-valued convolutional neural network (CvCNN) structure to be placed at the received side is proposed for nonlinearity compensation in a coherent optical system. This complex-valued global convolutional kernel-assisted convolutional neural network equalizer (CvGNN) has been verified in terms of Q-factor performance and complexity compared to seven other related nonlinear equalizers based on both the 64 QAM experimental platform and the QPSK numerical platform. The global convolution operation of the proposed CvGNN is more suitable for the calculation process of perturbation coefficients, and the global receptive field can also be more effective at extracting effective information from perturbation feature maps. The introduction of CvCNN can directly focus on the complex-valued perturbation feature maps themselves without separately processing the real and imaginary parts, which is more in line with the waveform-dependent physical characteristics of optical signals. Based on the experimental platform, compared with the real-valued neural network with small convolutional kernel (RvCNNC), the proposed CvGNNC improves the Q-factor by ∼2.95 dB at the optimal transmission power, while reducing the time complexity by ∼44.7%.
A Review of Natural Fiber-Reinforced Composites for Lower-Limb Prosthetic Designs
Authors: Castro-Franco Angel D. , Siqueiros-Hernández Miriam , García-Angel Virginia , Mendoza-Muñoz Ismael , Vargas-Osuna Lidia E. , Magaña-Almaguer Hernán D.
Published: May 2024

This paper presents a comprehensive review of natural fiber-reinforced composites (NFRCs) for lower-limb prosthetic designs. It covers the characteristics, types, and properties of natural fiber-reinforced composites as well as their advantages and drawbacks in prosthetic designs. This review also discusses successful prosthetic designs that incorporate NFRCs and the factors that make them effective. Additionally, this study explores the use of computational biomechanical models to evaluate the effectiveness of prosthetic devices and the key factors that are considered. Overall, this document provides a valuable resource for anyone interested in using NFRCs for lower-limb prosthetic designs.