bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of in vitro fertilization programs in patients with functual ovarian cysts and anovulatory infertility
Authors: Timofeeva O. S. , Petrov I. A. , Gaifulina J. F. , Tikhonovskaya O. A. , Logvinov S. V. , Samoilova Iu. G. , Petrova M. S. , Yuriev S. Yu. , Dmitrieva M. L. , Zhdankina A. A. , Gerasimov A. V. , Miheenko G. A.
Published: January 2024

Background. There are different opinions about the effect of functional ovarian cysts on the duration of controlled ovarian hyperstimulation, the dose of gonadotropins, the number and quality of collected oocytes and produced embryos, and the frequency of pregnancy.

Aim. To analyze in vitro fertilization (IVF) programs in women with anovulatory infertility and ovarian retention.

Materials and methods. A prospective study included 71 women aged 18–44 years. The main group (I) included patients (n = 38) with anovulatory infertility and functional ovarian cysts (FOC) diagnosed by ultrasound before enrollment in the IFV program. Patients of this group underwent ultrasound-guided transvaginal puncture of ovarian cyst followed by cytology. The comparison group (II) (n = 33) encompassed patients with anovulatory infertility without FOC, who went through the IVF program. The control group (III) included apparently healthy individuals (n = 15). The study algorithm included collection of clinical and anamnestic data of the patients, data of laboratory and instrumental studies, parameters of a stimulated IVF cycle, characteristics of oogenesis and early embryogenesis, and assessment of IVF program effectiveness.

Conclusion. It was established that in FOC and anovulatory infertility, the number of collected oocytes was smaller; however, the number of the best quality embryos and the frequency of pregnancy did not differ.
Quality of life and mental disorders in the post-COVID period (systematic review)
Authors: Semakin A. V. , Fedosenko S. V. , Malinovskiy V. A. , Agaeva S. A. , Starovoytova E. A. , Kalyuzhin V. V.
Published: January 2024

The 2019 novel coronavirus infection (COVID-19) pandemic has been a great burden for all of humanity. Soon after it began, researchers noticed that elimination of the virus from the body and recovery are not the end of the disease, since many patients did not return to their previous state of health, continued to complain of pathologies of various organs and systems, could not work, and some of them developed mental disorders.

The aim of the review was to analyze and summarize published data on the quality of life and mental disorders in the post-COVID period. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, 7,374 scientific works were found, of which 176 English-language and 276 Russianlanguage relevant publications were selected for analysis. The review included 17 (including 2 Russian-language) articles relevant to the topic of this review. Complaints of decreased memory and attention, appearing no later than 6 months after recovery from COVID-19, were reported by 3.2–9.1% of patients. Asthenic symptoms during the first month after the elimination of the novel coronavirus infection occurred in 55–70% of patients, and six months later – in every fifth patient. At the same time, post-viral fatigue more often affected women discharged from respiratory hospitals and persons with chronic bronchopulmonary pathology. Quite often, those who recovered from COVID-19 experienced insomnia and emotional disturbances, the frequency of which also correlated with the female sex and the severe course of the disease, which required hospitalization in the intensive care unit (ICU). In the post-COVID period, the development of depressive symptoms is not excluded, but sufficient evidence for this has not been obtained. The quality of life in these patients decreased. After discharge from the hospital, some patients remained unable to work, and some began to experience difficulties with self-care. However, over time, there is a trend toward restoration of the quality of life, which is especially evident in young people. In patients who have been in the ICU for more than 7 days, the rehabilitation potential is much lower. Psychopathological symptoms contribute to a decrease in the quality of life along with physical factors (persistent dyspnea, decreased exercise tolerance).
Study of wound-healing properties of humic substance – zinc complexes in the aseptic wound model in vivo
Authors: Zykova M. V. , Ivanov V. V. , Larionov K. S. , Azarkina L. A. , Buyko E. E. , Bratishko K. A. , Ufandeev A. A. , Rabtsevich E. S. , Mikhalev D. A. , Kopnov I. S. , Perminova I. V. , Belousov M. V.
Published: January 2024

The aim was to investigate wound-healing properties of zinc-containing biocomposites based on humic ligands (humic substance (HS) – Zn) in the in vivo experiment on the aseptic wound model and to evaluate their resorptive properties.

Materials and methods. The objects of the study were 5 samples of HS-Zn in the form of complex salts comprising fine black powders synthesized in the Laboratory for Natural Humic Systems of the Faculty of Chemistry at Moscow State University. The wound-healing effect of the substances was studied on 70 male Wistar rats using a traumatic model of an excisional aseptic skin wound. The degree of affected skin healing was evaluated during 21 days by the planimetric method. The resorptive properties of the HS-Zn samples were studied by inductively coupled plasma mass spectrometry (ICP-MS) in the biomaterial (blood serum, fur, skin from the wound surface).

Results. It was found that course application of zinc-containing HS-Zn biocomposites to the wound surface led to a decrease in the wound area in comparison with ZnSO4 with the equivalent concentration of elemental Zn (1.67 mg/ ml). Two samples FA-Zn and Peat1-Zn showed the most pronounced regenerating effect. We noted an increase in Zn level in the tested skin samples from the wound area, in fur, and in the blood serum, which indicates the resorptive effect of zinc-containing HS-Zn biocomposites during course application; however, the parameters did not exceed limiting permissible concentrations. The correlation between the tested samples was not equal, which indicates a significant impact of the initial HS matrix on the Zn bioavailability.

Conclusion. The observed reparative effect of zinc and HS complexes in the context of their low toxicity is of interest for further study to develop effective wound-healing preparations.
Levels of metalloproteinases and adipose tissue hormones in men with coronary atherosclerosis
Authors: Polonskaya Ya. V. , Kashtanova E. V. , Stakhneva E. M. , Ledovskikh S. R. , Garbuzova E. V. , Shramko V. S. , Kurguzov A. V. , Murashov I. S. , Sadovsky E. V. , Ragino Yu. I.
Published: January 2024

Aim. To study the effect of adipose tissue hormones on the level of metalloproteinases in men with verified coronary atherosclerosis and to assess associations between the studied biomarkers and abdominal obesity.

Materials and methods. The study included 96 men aged 58.9 ± 5.1 years: 80 men with angiographically verified atherosclerosis and class II–III angina pectoris and 16 men without atherosclerosis. Anthropometric parameters were measured in all patients, and their blood was taken on an empty stomach. The blood levels of adiponectin, leptin, resistin, adipsin, amylin, and metalloproteinases (MMPs) -1, -2, -3, -7, -9, -10, -12, -13 were determined by the multiplex analysis. Statistical processing of the results was carried out using the SPSS 13.0 software.

Results. In patients with severe atherosclerosis, lipocalin, MMP-1, MMP-7, and MMP-12 levels were higher than in the control group. The blood concentration of adiponectin in patients with atherosclerosis was reduced. Inverse correlations were revealed between waist circumference and concentrations of MMP-1 and MMP-12, as well as between body mass index and MMP-1. A moderate direct relationship was revealed between resistin and MMP-2 and MMP-3; between amylin and MMP-9; between adiponectin and MMP-12; between leptin and MMP-7.

Conclusion. The results obtained suggest a relationship between the level of damage markers and adipose tissue hormones, which lead to complications of cardiovascular diseases and explain the effect of obesity on atherosclerotic plaque destabilization.
Development of a Serious Game as an Educational Tool for Obesity Prevention
Authors: Kusumah Akmal Fauzi , Kurniawan Rahadian
Published: January 2024

As technology develops, many things can be used as methods in obesity prevention education, one of which is by creating an obesity prevention educational game. This educational game is designed with the aim of raising public awareness of what causes obesity in a different way. Through the development of the Digital Game Based Learning-Instructional Design (DGBL-ID) model, this research includes needs analysis, design, development, quality assurance, and game implementation & evaluation. Needs analysis involved an online survey of people with obesity, showing their interest in games as an educational medium. Game design involved storyboards and flowcharts, with the story being about Bono looking for healthy food for his obese friend. Development is done using Unity with an interface that includes the main menu, level list, stage list, game play, and game results. Quality assurance will involve black box testing and implementation evaluation by respondents. This article produces an obesity prevention educational game that is expected to increase public awareness about the risks of obesity through an interactive and informative game experience.
Molecular techniques for cancer diagnostics
Authors: Singh Vimal Kishor , Chandra Ramesh
Published: January 2024

Cancer cells differ from healthy tissues in their biological makeup. Recent research reported vast genetic and epigenetic heterogeneity, differences in the gene-expression profiles, and signal transduction networks in a broad range of cancers. These discoveries led to the development and clinical approval of several drugs that are more efficient and can specifically target cancer-specific pathways to provide a long-lasting cure. Recent advancements in describing genetic alterations in human cancers are a tempting reason for scientists to develop more effective, personalized therapies as the next level of cancer treatment. However, the drug discovery process is tedious, and getting approval from various regulatory authorities may be more frustrating for a steady developmental pace. Among various prime regulators, the most critical challenge and priority in oncology research is to define unique molecular biomarkers, which would enhance the diagnosis. These molecular biomarkers should have the potential to beacon the prognostics, design, and monitoring of the newer therapeutics. Several key findings are being identified to discover and validate such molecular biomarkers for their diagnostic potential at the DNA, RNA, and protein levels. Furthermore, noninvasive imaging technologies and serum biomarkers are promising higher quality outputs in a limited time which could be a useful tool to monitor early responses to the treatment and may be able to design the remedial course. These advances would pave the way for personalized cancer therapeutics if translated beyond scientific discovery. This article highlights the various aspects of translational research and associated issues i.e. trial design, tissue collection, and regulatory requirements.
Chondrogenic Cancer Grading by combining Machine and Deep Learning with Raman Spectra of Histopathological Tissues
Authors: Lazzini Gianmarco , D’Acunto Mario
Published: January 2024

The present paper explored the possibility of discriminating between different malignant degrees of Chondrosarcoma (CS), a diffused bone tumor, and Enchondroma (EC), its benign version, through an approach based on the coupling between Confocal Raman Microscopy (CRM) and Machine Learning (ML) techniques. Recently, Raman Spectroscopy has proven to be a powerful tool for a complete grading of CS by distinguishing between grade 1, 2 and 3, and to distinguish CS from EC. In this paper, we tested some models, belonging either to ML or to the sub-type called Deep Learning (DL), showing excellent classification performances, especially the DL algorithms, with classification accuracy approaching to 100%, making the models promising for future implementations of Raman spectroscopy when applied to oncology diagnosis. In turn, we highlighted how some proper ML models result in worse classification performances but better resolution of specific chemical target compounds, possible candidate to become malignant markers, with relevant implication for a correct diagnosis.
Nonverbal Behavior of Service Robots in Social Interactions – A Survey on Recent Studies
Authors: Leoste Janika , Marmor Kristel , Heidmets Mati
Published: January 2024

This study presents a literature review focused on nonverbal communication in human-robot interaction (HRI) that involves service robots with social capabilities. We aim to list the types of robots used and nonverbal communication cues examined in the reviewed studies; and the main research objectives, participant characteristics, data collection methods, and primary findings of these studies. To achieve this, we conducted a literature review of 39 relevant open access academic papers published from 2006 to 2023 that examined the utilization of nonverbal cues by both humans and robots during HRI. The results suggest that enhancing the quality of communication between humans and service robots must be improved, while there are several aspects that require more thorough exploring, needed to strengthen robot self-efficacy, trust and trustworthiness in HRI or overcome cultural differences. The results emphasize the importance of nonverbal communication in shaping the dynamics of interactions between humans and service robots.
Navigating the Complex Intersection of Substance Use and Psychiatric Disorders: A Comprehensive Review
Authors: Bahji Anees
Published: January 2024

The co-occurrence of substance use disorders (SUDs) and psychiatric conditions, often referred to as comorbidity or concurrent disorders, presents intricate challenges in both diagnosis and treatment. This comprehensive narrative review aims to synthesize and critically evaluate the existing evi-dence surrounding the management of individuals with comorbid SUDs and psychiatric disorders. Comorbidity in these domains carries profound implications for clinical practice, research, and policymaking, emphasizing the need for a holistic understanding of the intricate dynamics that arise when these conditions coexist. This review explores recent research findings, evidence-based guidelines, and emerging trends within the field, offering valuable insights for clinicians, re-searchers, and policymakers seeking to navigate the complex terrain of comorbidity in substance use and psychiatric disorders.
Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2
Authors: Patarca Roberto , Haseltine William A.
Published: January 2024

Viruses continue to provide vital insights into the field of control of gene expression. Viral transactivators, in concert with other viral and cellular proteins, regulate expression of self, other viruses, and host genes with profound effects on infected cells, underlying inflammation, control of immune responses, and pathogenesis. The multifunctional Tat proteins of lentiviruses (HIV-1, HIV-2, and SIV) transactivate gene expression by recruiting host proteins and binding to trans-acting responsive regions (TARs) in viral and host RNAs. SARS-CoV-2 nucleocapsid participates in early viral transcription, recruits similar cellular proteins, and shares intracellular, surface, and extracellular distribution with Tat. SARS-CoV-2 nucleocapsid interacting with the Replication-Transcription complex might, therefore, transactivate viral and cellular RNAs in transcription and reactivation of self and other viruses, acute and chronic pathogenesis, immune evasion, and viral evolution, constituting a potential pan-coronaviral therapeutic target. Here, we show by using primary and secondary structural comparisons that the leaders of SARS-CoV-2 and other coronaviruses contain TAR-like sequences in stem-loops 2 and 3, the coronaviral nucleocapsid C-terminal domains (N-CTDs) harbor a region of similarity to TAR-binding regions of lentiviral Tat proteins, and the coronaviral nonstructural protein 12 has a cysteine-rich metal binding, dimerization domain similar to that in lentiviral Tat proteins.
Phosphorus Adsorbed by Hydrochloric Acid Desorption–Activated Red Mud Adsorbents: A Molecular Dynamics Study
Authors: Li Longjiang , Yang Zhi wen , Qiu Yueqin , Wang Yalan
Published: January 2024

In this study, modified red mud after phosphorus adsorption was used as the adsorbent, and hydrochloric acid and deionized water were used as desorbents to desorb phosphorus. The components in the adsorbent were optimized based on density functional theory, and adsorbent and desorbent models were established. Molecular dynamics simulation was performed to determine the phosphorus concentration before and after desorption, interaction energies, radial distribution function(RDF), mean-square displacement(MSD), and diffusion coefficient. The Monte Carlo method was used to simulate the desorption isotherm, desorption site, heat of desorption, and desorption energy. Simulation results showed that deionized water could only desorb phosphorus on the adsorbent surface, and the stability of the system deteriorated upon adding hydrochloric acid. Hydrochloric acid destroyed the ionic and hydrogen bonding between the O atoms in H2PO4− and reactive metal and oxygen atoms in the activated red mud particles. Moreover, the van der Waals force decreased considerably. The ionic and hydrogen bonds between H2PO4− and the surface of activated red mud particles were broken by hydrochloric acid, which accelerated the desorption of phosphorus from the adsorbent surface. The interaction between hydrochloric acid and phosphorus accelerated the diffusion, which decreased the adsorption capacity. Moreover, the desorption capacity increased with increasing temperature.
Analysis of Women’s Poverty in Maluku Province
Authors: Daud Jumerti , Pulubuhu Dwia Aries T , Hasniati Hasniati
Published: January 2024

The Sustainable Development Goals (SDGs) aim to end poverty in all its forms everywhere and provide a gender-sensitive policy framework. Limited access to resources causes women to be more vulnerable to poverty and contributes to economic disadvantages, known as the feminization of poverty. Maluku Province is the fourth poorest province in Indonesia by 2022, with a poverty rate of 15.97 percent. The percentage of poor households headed by women is 7.03 percent, an increase of 0.83 percentage points from 2021. This research identifies the relationship between households headed by women and poverty in the Maluku Province. Secondary data were obtained from the National Socioeconomic Survey 2022 by the Central Bureau of Statistics. The sample size included 822 households headed by women. Binary logistic regression analysis was used in this study. The research found that area of residence, number of household members, education level, and employment sector significantly affected women's poverty status in Maluku. Furthermore, women's poverty was higher among rural residents. The findings highlight that the number of household members with family planning programs, better education, and government policies providing assistance for better agriculture can alleviate household poverty.
Analysis of the Teacher’s Role in Efforts to Emphasize Pancasila Profile Values in Classroom Culture SMK
Authors: Prihatiningrum Meida , Efendi Agus , Khurniawati Wiji
Published: January 2024

Educators must serve as role models for students by highlighting the ideals of the Pancasila student profile through their examples. Teachers who instruct in the classroom can impart this. Instructors serve as role models for moral behavior, modeling moral principles in their interactions and behaviors. Based on the Pancasila profile ideals, students are therefore more likely to emulate and accept the behavior displayed by their teachers. The purpose of this study is to describe two things: 1) how teachers implement Pancasila profile values to help students develop their character and behavior as a class culture; and 2) how they integrate Pancasila student profile values into the cultural context of vocational school classes. This kind of study is qualitative and descriptive. Participants in this study included two teachers one for the basic PPLG skills program and the other for homeroom as well as class X PPLG students. Two participants' in-person interviews, four hours of subject observation, and documentation were employed as the data-gathering methods. The study's findings demonstrate how X PPLG at SMK N Solo uses classroom culture as a platform for character development. Although there is no physical barrier between the teacher and the pupils in this approach, the teacher still serves as the class leader and an example for the students. The instructor highlights the importance of the Pancasila student profile in the learning process. This attempts to mold kids' honorable and moral character.
Students' Empathy Attitude in Helping To Overcome Difficulties in Mobile Device Programming Learning
Authors: Bella Setya , Basori Basori , Kurniasari Kurniasari
Published: January 2024

Learning is a process of making people or living creatures learn. Learning is very important for students in an era of increasingly rapid technology, one of which is learning to program mobile devices. Of course, in learning there must be achievements learning that must be achieved by students. To achieve learning, students must overcome challenges with different levels of difficulty. This level of difficulty can influence the emotional development of students, especially in providing a sense of empathy towards other students. This research raises the problem of the level of difficulty faced by students in the process of learning mobile device programming and how to empathize in helping students overcome these difficulties. This research method uses a qualitative method with a descriptive approach where the researcher describes the literature review and describes the answers to existing problems. By collecting data through interviews, observations and literature studies. This research was carried out at one of the 11th grade Surakarta State Vocational Schools in phase F on the achievements per mobile device programming element. Based on the results of research in learning mobile device programming, educators know the importance of understanding students' level of difficulty using theory Bloom's Taxonomy and students' empathetic attitude towards the difficulties they face based on Erik Erikson's theory. So that an empathetic attitude can influence students' success in achieving learning.
Teacher’s Efforts to Improve the Moral Development of Vocational School Students
Authors: Novianingsih Affifah , Efendi Agus , Khurniawati Wiji
Published: January 2024

There is no denying that teens' morals are impacted by globalization. This phenomena highlights the need for moral education, particularly at the vocational school level, where students will eventually enter the workforce. As such, moral education is extremely important because it focuses on improving character and ethics in addition to competency development. The role of instructors becomes crucial in promoting ethics, morals, and character. This study aims to describe teacher's efforts to increase the moral development of students at the vocational school level and impact its implementation. Data collection techniques use observation and interviews. The research method uses descriptive qualitative. Participants were chosen with the technique of purposive sampling. Data analysis using data reduction, data presentation, conclusions, and verification. Research results show teachers’ efforts to increase the moral development of students at the vocational school level are carried out during learning to become exemplary, instill Pancasila values, habituation culture work, push learning peers, and gift constructive feedback proven own impact positive to the moral development of students with indication that students showing moral values according to Thomas Lickona. This research gives the line bottom importance of teachers' efforts to improve participant morale in vocational high school education as preparation for facing current globalization and the demands of the world of work.

Keywords: Moral Development, Students, Teacher Efforts, Vocational School Students
Analisis Kemampuan Awal dalam Penyelesaian Projek Mata Pelajaran Pemrograman Web dan Perangkat Bergerak
Authors: Sutanto Himawan , Basori Basori , Kurniasari Kurniasari
Published: January 2024

Untuk mengetahui kemampuan awal peserta didik, terutama kelas PPLG guru tidak menggunakan pretest, tetapi guru menggunakan strategi untuk belajar bersama, guru memberikan pertanyaan yang dapat dijawab bersama-sama, dari hal tersebut akan terlihat kemampuan awal siswa, dari siswa yang antusias menjawab dan siswa hanya diam dan acuh atau guru juga memberikan pertanyaan sesuai dengan absen siswa, kemudian siswa yang telah Berdasarkan wawancara dengan guru pamong yaitu Ibu Kurniasari, S.Pd., S.Kom. bahwa untuk kemampuan awal peserta didik dimulai dari aktif dalam menjawab pertanyaan pemantik awal yang diberikan oleh guru. sehingga memicu pikiran, merangsang pertimbangan, dan mengaktifkan pemikiran kritis peserta didik sebelum materi pelajaran utama dimulai.
The Influence of Implementing Government Accounting Standards Based on Competence with The Use of Accounting Information Systems as A Moderation Variable
Authors: Kristiana Ida , Erlangga Ega Priyatna , Sinarasri Andwiani
Published: January 2024

This study aims to empirically prove the influence of the Human Resources Quality, Internal Control Systems, on the Successful Implementation of Accrual-Based SAP with the Utilization of AIS as a Moderation Variable for a study on the Central Java Provincial Government OPD using a saturated sample of 38 Central Java Provincial Government OPD. The statistical method used is Partial Least Square (PLS). The research results show that; HR Quality has a positive effect on the successful implementation of accrual-based SAP, Internal Control System has no effect on the successful implementation of accrual-based SAP, Utilization of AIS makes the relationship weaker between HR Quality and Successful Implementation of Accrual-based SAP, Utilization of AIS cannot moderate the relationship between Internal Control Systems and Successful Implementation of Accrual-based SAP.
The The Influence of Auditor Competence and Integrity on Audit Quality with the Implementation of Quality Assurance as a Moderating Variable (Study at the Audit Unit of the Regional Office of DJBC East Java I)
Authors: Perdana Taufan Aditya , Wahidahwati Wahidahwati , Priyadi Maswar Patuh
Published: January 2024

This research aims to test and analyze the influence of auditor competence and integrity on audit quality by applying quality assurance as a moderating variable, research at the audit unit of the East Java I Regional Office of the Directorate General of Customs and Excise. This type of research is quantitative research. The population of this study are functional auditors and executive examiners who are tasked with assisting the implementation of audits. The sampling technique uses a saturated sample, namely the entire population of 47 people as the research sample. The data analysis technique for testing hypotheses uses Partial Least Square – Structural Equation Modeling with the SmartPLS program. The research results show that: 1) auditor competency has a significant and positive effect on audit quality, 2) auditor integrity has a significant and positive effect on audit quality, 3) the application of quality assurance has a significant and positive effect on audit quality, 4) the application of quality assurance does not moderate the effect auditor competency on audit quality, 5) implementation of quality assurance does not moderate the influence of auditor integrity on audit quality
Proyecto para la comercialización de carbón a base de cáscara de coco
Authors:   , Negrete Abad Sahury Elizabeth , Gamonal Huaman Lucero , Roldan Cubas David Alexander , Tam Castañeda Ruben Masiel , Guerra Garay Soledad Karina
Published: January 2024

El actual trabajo de investigación de plan de negocios está enfocado a proponer el consumo de carbón a base de coco para las preparaciones de alimentos en los negocios y hogares en Perú. La tala de los árboles produce más del 30% de gases de efecto invernadero, esta cifra alarmante nos incentivó a ayudar al planeta elaborando un producto ECO AMIGABLE para disminuir la deforestación y, por ende, el incremento del calentamiento global. Por ello se nos presentó la siguiente pregunta ¿podemos elaborar un producto que no solo sea del agrado de los consumidores, sino que también ayude a disminuir el incremento del calentamiento global en el Perú? Bajo esta premisa, Podemos indicar que nuestro producto el carbón de coco es 100% natural, considerado también como un producto menos contaminante. Por otro lado, en nuestra investigación se pudo indicar que hay una gran cantidad de personas que no están interesadas en cuidar el medio ambiente en el Perú, pero también que existe una demanda creciente de productos ECO AMIGABLES. Con esta iniciativa buscamos ingresar al mercado concientizando el uso de un producto eco amigable y a la vez agradable para el uso cotidiano. Una vez establecido en el mercado buscamos incrementar nuestras ventas en un 20% implementando nuestras estrategias de marketing. Nuestro proyecto iniciará sus operaciones comercializando desde lince alcanzando un 50% de aceptación para incrementar en 30% la comercialización de eco carbón. Al conocer estos resultados de la investigación, nuestro producto el ECOCARBÓN hecho a base de carbón activado, que su característica principal es su larga duración y la contribución con el medio ambiente...
Relación de las maloclusiones y los patrones faciales según Capelozza en adolescentes peruanos
Authors:   , Huayta Diaz Sandra Naomi , Custodio Aucasime Miguelangel
Published: January 2024

El estudio tuvo como objetivo determinar la relación entre las maloclusiones con los patrones faciales. Este estudio analítico transversal evaluó una muestra a conveniencia de 81 adolescentes peruanos (36 mujeres y 45 varones) de 14 a 16 años de un colegio público de Lima. Las Fotografías intraorales (frontal y laterales) se utilizaron para clasificar maloclusiones según Angle (I, II-1, II-2, y III), mientras que las fotografías extraorales (frontal y perfil) se revisaron para clasificar los patrones faciales según Capelozza (I, II, III, cara larga y corta). Todas las fotografías fueron evaluadas en el editor Microsoft Power Point versión 2021. Las comparaciones se analizaron con la prueba de chi-cuadrado, Kruskal-Wallis, y correlación de Spearman. Los resultados muestran que las prevalencias más frecuentes en maloclusión fueron la clase I (58%) y clase II-1 (21%), y en patrón facial fueron la clase I (43,2%) y la clase II (30,9%). Ni la maloclusión ni el patrón facial se asociaron al sexo o edad (P≥0,05). La maloclusión y el patrón facial se correlacionó significativamente (rho=0,341; P=0,022; positiva baja) solo en los varones donde la asociación mostró una mayor distribución de patrones faciales clase I, II, y cara larga en maloclusión clase I (48% a 75%), y el patrón cara corta en maloclusión clase II-1 (100%) (P=0,022). Se concluyó que las maloclusiones según Angle y los patrones faciales según Capelozza valoradas mediante fotografías solo se correlacionó en varones.
Asociación entre desgaste dental y estrés/ansiedad en niños: revisión sistemática
Authors:   , Lossio Hawkins Alessandra
Published: January 2024

Esta revisión sistemática tuvo como objetivo determinar la asociación entre el desgaste dental y el estrés/ ansiedad en niños de 3 a 12 años. La búsqueda se realizó en las bases de datos Scopus, Medline vía Pubmed, Ebsco, Scielo y Science Direct; y en repositorios y revistas científicas sin restricción de fecha de publicación. La pregunta PECOS tuvo como componentes (P) niños de 3 a 12 años, (E) estrés y/o ansiedad, (C) desgaste en dientes deciduos y/o permanentes, (O) comparaciones en proporción, correlación, odds ratio o riesgo relativo, y (S) estudios de tipo transversal, cohortes y casos y controles. La selección de estudios se realizó por fases desde revisión de títulos y resumen según criterios de selección, eliminación de duplicados, y revisión exhaustiva a texto completo. La evaluación del riesgo de sesgo y la síntesis cualitativa se analizaron con la escala de New Castle-Ottawa. De un total de 1861 estudios, se consideraron elegibles 3 artículos en la evaluación cualitativa. Los estudios mostraron una fuerte relación entre el desgaste dental y el estrés/ansiedad en niños. Todos los artículos mostraron un riesgo alto de sesgo, teniendo la comparabilidad y exposición como principales problemas. La limitada evidencia disponible mostró una asociación del desgaste dental y estrés/ansiedad en niños.
Relación del bruxismo y la calidad de sueño en estudiantes de Odontología de una Universidad Privada de Perú
Authors:   , De Los Santos Ramirez Miluska Andrea
Published: January 2024

Objetivo: Determinar la relación entre la calidad de sueño y bruxismo en estudiantes de odontología de una universidad privada de Perú. Metodología: La presente investigación observacional transversal fue aplicada a una muestra de 231 estudiantes de estomatología de la Universidad Científica del Sur. Un cuestionario virtual se utilizó para recolectar datos del sexo, ciclo de estudios, bruxismo vigilia (BV) o de sueño (BS) y calidad de sueño analizado con el Índice de Pittsburg. El instrumento fue sometido a validación de tres expertos y confiabilidad (0,99). La relación del bruxismo según nivel de calidad de sueño se realizó con la Prueba de chi2 y según el puntaje Pittsburg con la prueba de U de Mann-Whitney. Resultados: El bruxismo y la calidad de sueño (Puntaje Pittsburg) no encontraron asociadas (p>0,05). Los porcentajes de afectación fueron en BV de 29,9%, en BS de 22,5% y en calidad de sueño mala y muy mala de 22,9%. Un mayor BV se presentó en varones que en mujeres (P<0,01). Los ciclos superiores se relacionaron a BV (VI al IX) y BS (VIII al X) (P<0,05). Conclusión: La mayoría tuvieron una buena calidad de sueño y no presentaron bruxismo encontrándose que no hubo relación entre ambas variables.
Statistics and Case Studies of Drainage Frac Height and Zonal Contribution of Stacked Plays in the Midland and Uinta Basin
Authors: Ge Shuangyu , Bachleda Jana , Fidler Luke , Sigler Josh , Lv Tao , Liu Faye
Published: January 2024

In this study, we present statistics of the drainage behavior of 387 wells in the Midland and Uinta Basins, including drainage frac height (DFH), zonal contribution, and their variation throughout the life of the well. Case studies from both basins will also be presented to demonstrate how drainage information is utilized to achieve improved reservoir economics.

A geochemistry-based method is used to quantitatively monitor drainage evolution and zonal contribution, and their variation through time. Produced oils are correlated to their contributing intervals represented by rock samples, allowing for a detailed quantitative analysis of the drainage behavior of the well. Statistical analysis is conducted on the production allocation results of 387 wells to evaluate their drainage behaviors. The study also leverages key reservoir properties derived from geochemistry using Reservoir Characterization Indices (RCI) to provide insights into drivers of the drainage behavior observed.

In the Midland Basin, 90% of the P80 DFH (drainage frac height that covers 80% of production) falls between ~155’ to 400’, with a median of ~290’. In the Uinta Basin, it falls between ~80’ to 305’ with a median of ~210’. To evaluate the effectiveness of reservoir recovery, we also analyzed how much contribution is from outside the targeted interval, or "out-of-zone", vs. contribution from inside the targeted interval, or "in-zone" contribution. In the Midland Basin, the median "in-zone" contribution ranges from 65% to 100% for wells targeting Middle Spraberry through Wolfcamp. In the Uinta Basin, it ranges from 43% to 80% for wells targeting Castle Peak through Wasatch. Without considering the total reservoir thickness, the richness of geological zones in the Uinta Basin could be comparable to or even better than some of the zones in the Midland Basin based on the production contribution per 10 feet of thickness (PCPT). The Midland case presents that co-development wells show as much as 70% larger P80 DFH than parent wells. The staggered co-development approach outperforms stacked co-developed scenarios, having ~32% more contribution from superior reservoirs than other development scenarios. The Uinta Basin study compares cube-developed wells to individually developed wells. A significant observation is that ~40% of cube-developed wells exhibit a noticeable drainage change (>20’), in contrast to only ~30% of individually developed wells, suggesting cube-developed wells effectively create SRV across the stacked reservoirs without overcrowding wells.

The study presents novel information about drainage behaviors and provides quantitative data for regional assessments and benchmarking in the Midland and Uinta Basin.
Real-time Awareness: A Novel Application of Fiber Optics to Optimize Simultaneous Operations of Drilling and Frac
Authors: Stark Price , Adil Faraaz , Woodward Beau , Treviño Julio , Steinhoff Chris , Gallegos Dana
Published: January 2024

It is challenging for asset management teams to balance the schedules of drilling rigs and frac fleets based on ever-changing schedule constraints and the potential of subsurface interference. These challenges increase as assets mature, causing last-minute changes in pad sequencing or pausing drilling and frac operations. To mitigate fracture-driven interactions (FDIs) and minimize schedule disruptions, the service company and operator team deployed disposable fiber optics in two lateral wells between adjacent drilling and frac operations. These fibers functioned as security fences, watching for approaching fractures heading for the drilling wellbore. The operator could immediately act on the completion pad if an approaching fracture threatened the rig.

Disposable fiber optics have existed for several years, gaining favor due to the ease of operation, low comparable cost, and value of the data provided. The value of the data includes using acoustic distributed sensing strain data to observe the approaching fractures from a nearby treatment well. The system can detect fractures that directly intersect the monitoring well and fractures passing nearby or approaching. For processing, machine learning (ML) systems, overseen by human analysts, monitored and identified FDIs in real-time and relayed them to the team managing the operation.

This operation is the first instance where disposable fiber, or any fiber, was used explicitly for managing simultaneous subsurface operations. Historically, fiber is considered a high-cost diagnostic, unsuited for this common operational challenge. Now, it is operationally and economically viable to use it for routine purposes.
Methods for Assessing Proppant Coverage Along the Lateral for Plug-And-Perf Treatments
Authors: Cramer David , Friehauf Kyle
Published: January 2024

This paper documents the results of diagnostic tests in a well that was equipped with measuring devices for analyzing pressure and acoustic behavior during multistage fracturing treatments. This well was also surveyed by an ultrasonic device for measuring the entry hole sizes of treated and untreated perforations. Well and treatment design parameters selected for scrutiny included cluster perforation density and the circumferential phase angle of entry holes with respect to elevation.

Perforation erosional analysis was performed on each frac stage of the diagnostic wells by comparing perforation sizes of treated perforations with intentionally untreated perforations to estimate the eroded area for each perforation, then applying a two-component erosion model to allocate proppant among all the clusters for that frac stage. The allocated proppant was then used to compute treatment uniformity and compared with allocation and uniformity values determined by the DAS provider. This unique dataset was used to perform five categories of analyses: pipe/casing friction pressure, step down testing, perforation entry hole erosion, treating pressure, and inter-cluster proppant allocation and uniformity.

Determination of perforation entry-hole erosion parameters are shown to have diagnostic value in assessing treatment confinement and identifying deviations from standard erosion theory. The impact of variable and uncertain initial (untreated) entry hole sizes is shown to adversely impact the accuracy of both DAS and erosion-based proppant allocation routines. Evidence is provided quantifying the negative effect of proppant separating from the fluid stream due to inertia on the accuracy of treatment distribution provided by DAS interpretation.
A Successful Acid Fracturing Treatment in Asphaltene Problematic Reservoir, Burgan Oilfield Kuwait
Authors: Al-Shammari A. , Sinha S. , Sheikh B. , Youssef A. , Jimenez C. , Al-Mahmeed F. , Al-Shamali A.
Published: January 2024

The Burgan Marrat Reservoir is a challenging high-pressure, high-temperature carbonate oil reservoir dating back to the Jurassic age. This specific reservoir within the Burgan Field yields light oil, but it has a significant issue with Asphaltene deposition in the wellbore. Additionally, its well productivity is hampered by low matrix permeability. Addressing these challenges is crucial, and a successful acid fracturing process can not only enhance well productivity but also address Asphaltene-related problems.

This study delves into a comprehensive methodology that was employed. The focus of well selection was on ensuring good well integrity and maintaining a considerable distance from the oil-water contact (OWC). The approach involved conducting a Multi-Rate test followed by pressure build-up to establish a baseline for understanding the reservoir's behavior, including darcy and non-darcy skin.

The treatment design aimed at better fluid loss control and initiating highly conductive fractures in the reservoir. Specific measures, such as using suitable diverters and acid, were employed to maximize the length of the fractures. To validate the approach, a nodal analysis model was fine-tuned to predict how the well would perform under these conditions.

The results post-stimulation were impressive. There was a substantial improvement in well production and flowing bottom hole pressure. In fact, the productivity index of the well increased significantly, representing a substantial enhancement in output. The pressure build-up test after the fracture demonstrated a linear flow within the fracture, indicating a successful treatment with a fracture half-length of approximately 110 feet and a negative skin, which signifies an improvement in flow efficiency. Furthermore, the treatment effectively mitigated the risk associated with Asphaltene deposition, a significant accomplishment given the historical challenges faced in this reservoir.

This success can be attributed to an innovative workflow that incorporated a meticulous surveillance plan, a well-thought-out fracturing treatment design, and the application of advanced nodal analysis. Together, these components not only optimized the well's performance but also paved the way for the development of similar high-pressure, tight carbonate reservoirs. This approach not only enhances productivity but also ensures successful mitigation of Asphaltene-related issues, marking a significant advancement in reservoir engineering techniques.
Managing Friction Pressures to Reduce Fuel Consumption and Emissions for a Fracturing Fleet
Authors: Beveridge Zacary , McLaughlin Nathan , Kakadjian Sarkis
Published: January 2024

Friction pressure has always been a limiting factor for placing water and proppant during a hydraulic fracture treatment. Mitigating friction pressure has relied heavily upon using chemicals to reduce the friction and ultimately the hydraulic horsepower required to complete the job. Costs to reduce friction pressure have always been associated with the type and amount of friction reducer (FR) used. Best practices being associated with using as little as necessary to achieve the treatment. On the contrary, utilizing the minimum amount of FR can increase overall costs for treatment due to increased fuel usage which leads to increased emissions. As the industry strengthens focus surrounding Environmental, Social, and Governance (ESG) and optimizing costs for well completions, this paper discusses a unique approach to decrease friction pressures, reduce fuel usage, and ultimately optimize the completions treatment and associated cost.

Using friction models based on laboratory data and fuel consumption models built from flowmeter measurement during treatment, various pumping scenarios can be combined to estimate fuel consumption for diesel and dual fuel engines at varying FR set points. Incorporating a friction pressure model allows for treating pressure to be estimated and used within the fuel consumption model. Providing commodity costs and emissions factors allows for understanding of total cost and emissions changes with increased FR usage. Varying FR usage, treatment rate, and number of pumps gives room for optimization and understanding of the variables that demonstrate the greatest effect on total costs and emissions.

Increasing FR leads to decreased treating pressure and required hydraulic horsepower which reduces fuel consumption and generated emissions. The cost reductions depend on commodity prices as well as the types of fuel used (diesel or a blend of diesel and natural gas). Utilizing current market pricing, an increase in FR concentration from 0.4 gal per thousand to 0.6 gal per thousand resulted in a decrease in overall costs of nearly 5% per pumping hour and emissions reductions of up to 15.9%. By changing the conventional wisdom of lowering costs by reducing chemical concentrations to optimizing based on the bigger picture, emissions, treatment costs, and equipment utilized are reduced. Additional horsepower can be utilized for backup and further reduce non-productive time and increase efficiency. With proper planning and understanding, this solution will provide a more efficient environment for completions.