bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Pembuatan Media Pembelajaran Bahasa Arab Berbasis Aplikasi Android Untuk Guru di Kabupaten Ponorogo
Authors: Shiddiq Jamaluddin , Ghafar Muhammad
Published: August 2022

This study focuses on assisting the manufacture of android-based Arabic learning media for partner teachers in the district. Ponorogo and answering two questions, that is how to design and implement android-based learning media for Arabic teachers?. This study is based on the findings of problems that indicate a lack of knowledge and lack of training on the object of service regarding learning media. This service research uses the Participatory Action Research (PAR) method which includes four stages: diagnosing, action planning, taking action and evaluating. The results showed: 1) the design of android-based learning media includes 2 stages, namely designing wordwall games, and converting wordwall games to android applications with kodular.io. 2) implementation in learning includes: 1) the preparation stage (register an account on the wordwall page, choose the create activity and template provided and design and create content), 2) introduction (greetings, prayers and apperception), 3) core activities (application demonstrations), applying games, question and answer and discussion) and closing (reflection, follow-up plans, prayers and greetings)

Abstrak

Penelitian ini berfokus pada pendampingan pembuatan media pembelajaran bahasa Arab berbasis android bagi guru mitra dampingan di Kab. Ponorogo dan menjawab dua pertanyaan, yaitu bagaimana merancang dan mengimplementasikan media pembelajaran berbasis android bagi guru bahasa Arab?. Hal ini didasarkan pada temuan permasalahan yang menunjukkan kurangnya pengetahuan dan minimnya pelatihan objek pengabdian mengenai media pembelajaran. Penelitian pengabdian ini menggunakan metode Participatory Action Research (PAR) yang meliputi empat tahapan: diagnosing, action planning, taking action dan evaluating. Hasil penelitian menunjukkan: 1) perancangan media pembelajaran berbasis android meliputi 2 tahap, yaitu merancang game wordwall, dan convert game wordwall ke aplikasi android dengan berbantukan kodular.io. 2) implementasi dalam pembelajaran meliputi: 1) tahap persiapan (register akun di laman wordwall, memilih create activity dan template yang disediakan serta merancang dan membuat konten), 2) pendahuluan (salam, doa dan apersepsi), 3) kegiatan inti (demontrasi aplikasi, menerapkan permainan, tanya jawab dan pembahasan) dan penutup (refleksi, rencana tindak lanjut, doa dan salam)
Vessels that encapsulate tumor clusters (VETC) pattern predicts the efficacy of adjuvant TACE in hepatocellular carcinoma
Authors: Wang Jia-hong , Li Xiao-shan , Tang Hong-sheng , Fang Run-ya , Song Jing-jing , Feng Yan-lin , Guan Tian-pei , Ruan Qiang , Wang Jin , Cui Shu-Zhong
Published: August 2022

Background: Postoperative adjuvant transcatheter arterial chemoembolization (TACE) is regarded as a common strategy for hepatocellular carcinoma (HCC) patients at a high risk of recurrence. However, there are currently no clinically available biomarkers to predict adjuvant TACE response. Vessels that encapsulate tumor clusters (VETC) can be used as an independent predictor of HCC prognosis. In this study, we aimed to explore whether the VETC pattern could predict adjuvant TACE benefit.Methods: Vascular pattern and HIF-1α expression was detected in immunohistochemistry. The survival benefit of adjuvant TACE therapy for patients with or without VETC pattern (VETC+/VETC-) was evaluated.Results: The adjuvant TACE therapy obviously improved the TTR (median TTR: 10.0 vs. 36.0 months, P = 0.008) and OS (median OS: 17.7 vs. 53.2 months, P = 0.005) in VETC+ patients, while adjuvant TACE therapy could not benefit from VETC- patients. Univariate and multivariate analysis revealed that adjuvant TACE therapy significantly improved the TTR and OS in VETC+ patients, but not in VETC- patients. In addition, the VETC+, but not VETC-, patients could benefit from adjuvant TACE therapy in patients with high risk factors of vascular invasion, larger tumor or multiple tumor. The mechanistic investigations revealed that the favorable efficacy of adjuvant TACE on VETC+ patients, but not VETC- ones, may be not due to the activation of HIF-1α pathway.Conclusions: The VETC pattern may represent a novel and reliable factor for selecting HCC patients who may benefit from adjuvant TACE therapy, and the combination of VETC pattern and tumor characteristics may help stratify patients’ outcomes and responses to adjuvant TACE therapy.
Is the addition of spray homeopathic in feed able to change dog behavior?
Authors: Galli Gabriela Miotto , Glombowsky Patricia , Silva Aleksandro Schafer da
Published: August 2022

This study aimed to determine if the homeopathic formulation based on Natrum muriaticum, Matricaria, Chamomilla, and Ignatia amara was effective for stress control in dogs in order to prevent and/or reduce the frequency of unwanted behaviors. Ten male beagle dogs were divided into two groups, with five animals per group. The control group was animals receiving 0.5 mL/day of placebo via spray in the feed for 30 consecutive days as a preventive. The treated group received 0.5 mL/day of tested drug spray in the feed for 30 consecutive days as a preventive. Behavioral tests were performed at two time points, before and after receiving the tested drug. We performed the following behavioral tests: a) persons known and unknown in the internal and external environment; b) interaction with toys; c) interaction with an unknown dog, d) test with a leash; and e) firecracker test. There was more engagement in digging and scaling the fence in the control group than in the treatment group (P < 0.05). The animals that received homeopathic medicine sat 2.54 times longer than the control (P = 0.0269). Dogs that received homeopathic showed 4.49 times more interest in general at D30 than at D1 (P = 0.0214). Animals in the treated group showed an 83% less chance of urinating than the control group in the tests involving displacements. We conclude that the preventive addition of homeopathic medicine containing Natrum muriaticum, Chamomilla, and Ignatia amara reduced undesirable behaviors related to anxiety and increased the incidence of interest behavior.
PELAKSANAAN PENYELESAIAN SENGKETA BANDING PAJAK PERTAMBAHAN NILAI DI PENGADILAN PAJAK (STUDI KASUS PADA PT. MPFI)
Authors: Sukmawati Anisya , Bukhori Aan
Published: August 2022

Pelaksanaan Penyelesaian Sengketa Banding Pajak Pertambahan Nilai di Pengadilan Pajak (Studi Kasus pada PT. MPFI). Penelitian ini membahas pelaksanaan penyelesaian sengketa banding Pajak Pertambahan Nilai studi kasus pada PT. MPFI di Pengadilan Pajak. Sengketa banding ini diawali dengan keberatan wajib pajak atas terbitnya SKPKB oleh Kantor Pelayanan Pajak Penanaman Modal Asing Satu. Penelitian ini bertujuan untuk mengetahui pelaksanaan Banding dalam penyelesaian sengketa Pajaki  Pertambahan Nilai di Pengadilan Pajak. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Hasil dari penelitian ini menunjukkan bahwa pelaksanaan banding dari PT. MPFI telah sesuai dengan ketentuan yang berlaku. Putusan Majelis Hakim yang mengabulkan sebagian permohonan banding tidak berpengaruh pada terhadap PPN yang masih harus dibayar, karena tarif PPN atas Penjualan Ekspor adalah 0% dan tidak terdapat sanksi administrasi. Berdasarkan hasil penelitian ini, disarankan kepada Wajib Pajak diharapkan dapat mengkaji lebih dalam tentang Undang-Undang atau peraturan tentang penggunaan tanggal kurs yang digunakan dalam mengonversi kedalam mata uang rupiah pada pelaporan PPN, sehingga tidak terjadi koreksi lagi pada masa pajak berikutnya, kemudian dalam melakukan koreksi seharusnya Direktorat Jenderal Pajak melakukan pemeriksaan dengan komprehensif, yaitu dengan memadukan beberapa dasar peraturan terkait pokok koreksi. Selain itu, Direktur Jenderal Pajak diharapkan untuk lebih meningkatkan penyuluhan, dan koordinasi dengan mitra Bank Persepsi serta mengoptimalkan pemanfaatan teknologi yang terintegrasi.

 
Manajemen Sekolah Hijau di SD Negeri 05 Beji Kabupaten Pemalang
Authors: Eliyanti Widi , Abdullah Ghufron , Wuryandini Endang , Suharyadi Aris , Suharyadi Aris
Published: August 2022

Sekolah hijau merupakan bagian dari Program Adiwiyata yang bertujuan untuk memelihara dan membangun kondisi sekolah yang hijau dan sehat. Penelitian ini bertujuan untuk mendeskripsikan manajemen sekolah hijau di SD Negeri 05 Beji Kabupaten Pemalang.  Metode penelitian dalam kajian ini menggunakan penelitian kualitatif.  Subyek penelitian adalah kepala sekolah, guru, staf, siswa, orang tua wali, dan masyarakat sekitar sekolah.  Obyek penelitian yaitu situasi sosial yang menunjukkan manajemen sekolah hijau. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Teknik analisis data menggunakan model interaktif Miles dan Huberman. Uji Keabsahan menggunakan triangulasi teknik.  Hasil penelitian menunjukkan bahwa manajemen sekolah hijau mencakup kebijakan sekolah berwawasan lingkungan, kurikulum berbasis lingkungan, kegiatan berbasis partisipatif, dan pengelolaan sarana dan prasarana pendukung ramah lingkungan sudah terinternalisasi dengan baik. Hal ini dibuktikan dengan kegiatan: (1) perencanaan sekolah hijau dilaksanakan dengan memuat aspek pendidikan lingkungan hidup dan melibatkan masyarakat sekitar dalam memberikan pertimbangan dan masukan, (2) pengorganisasian dilakukan dengan pembentukan tim koordinator sesuai dengan program kerja dan peran serta fungsi masing-masing, (3) pelaksanaan diwujudkan dengan adanya berbagai kebijakan dan program kegiatan, pembelajaran terintegrasi lingkungan hidup, peningkatan partisipasi warga sekolah, sarana dan prasarana yang mencukupi dan mendukung pendidikan lingkungan hidup, (4) pengendalian dilaksanakan melalui kegiatan evaluasi dan monitoring yang dilakukan secara rutin dalam bentuk peraturan terulis, teguran lisan, imbauan, pembinaan, maupun pemberian penghargaan.
Classification of environmental crimes related to the integrated inspection of Ponta do Abunã in Rondônia, Brazil
Authors: Paraguassú-Chaves Carlos Alberto , Salton Ronaldo André Bezerra , Barcellos Xavier Delson Fernando , Rivoiro Marcus Vinicius , Almeida Fabrício Moraes de , Dantas Lenita Rodrigues Moreira , Trindade Carla Dolezel , Filho Simão Aznar , Smith Ruy Drummont , Aznar Simão Dolezel
Published: August 2022

The main research problem is whether it is possible to typify and establish a correlation of environmental crimes from the integrated inspection operation known as "Ponta do Abunã" in Rondônia, in the border region between the states of Acre, Amazonas and Rondônia, in two different periods? To answer this question, the general objective of the research was to analyze the typology of environmental crime resulting from the integrated inspection action of IBAMA Superintendências do Acre, Amazonas and Rondônia and other command and control bodies carried out in the Ponta do Abunã region, located in municipality of Porto Velho, Rondônia, Western Amazon. This is a documentary and qualitative research, having as place of research the legal office of IBAMA/Rondônia. For the documentary analysis, 2 semi-structured instruments composed of 3 axes were used, containing the typology of the environmental crime, infraction notices and instruction and embargo term and, current stage or judgment of the process. The results indicate that the harmful conducts to the environment are prolonged throughout the analyzed period. Legislation is able to typify illegal actions and concrete actions fit the legal precept issued by the legislator. The delay in the judgment of the infraction notices analyzed is a real fact that requires a more agile response from the environmental sanctioner.
MARITIME SECURITY IN THE INDO-PACIFIC REGION: A VIEW FROM THE GEOSTRATEGIC POSITION OF THE MALACCA STRAIT
Authors: Tuan Binh Nguyen , Xuan Hiep Tran , Hoang Long Tran
Published: August 2022

Maritime security has been in recent times emerged as a burning issue in the fields of international relations in general and in the Indo-Pacific region in particular. With topographical tectonics, this area includes numerous “choke points” on maritime routes that are strategically important to world trade, playing an important role in the transportation of oil, gas and cargo products from the Middle East to Australia and East Asia. Therefore, maritime security issues for the lifeline of the world economy are concerned by the countries in the Indo-Pacific region, in which the important role of the sea route through Straits of Malacca is increasingly emphasized. With a geostrategic position connecting the Andaman Sea (Indian Ocean) and the South China Sea (Pacific Ocean), Straits of Malacca is the shortest route between the Middle East and Asia in general and Pacific Rim countries in particular. This is the location that accounts for a quarter of the world’s marine traffic annually. Energy security and trade economy of major powerful countries in the Indo-Pacific region depend heavily on the maritime security of Straits of Malacca route. Through an analysis of the Malacca Strait’s geostrategic location, this paper elucidates the Indo-Pacific region’s importance in maritime security field in the first two decades of the twenty-first century.
Community structure and diversity of endophytic bacteria in different niches of camellia oleifera
Authors: Yang shunxing , Yang zhannan , luo shiqiong , quan wenxuan
Published: August 2022

Endophytic bacteria are important for plant growth, stress tolerance and
metabolite synthesis. Camellia oleifera is a unique woody oil crop in
China, and the bacterial communities at different niches have not been
fully reported. To investigate the structural characteristics and
diversity of bacterial communities in different niches of C. oleifera,
we applied high-throughput sequencing technology on the Illumina MiSeq
platform to explore the diversity of bacteria species in roots, stems,
leaves, inter-rhizosphere soils and non-rhizosphere soils of C.
oleifera. We obtained 3,127 OTUs (operational taxonomic units) from five
samples, belonging to 16 phyla, 58 orders, 91 families, 162 families and
249 genera; the abundance and diversity of bacterial communities in
different niches of C. oleifera decreased from bottom to top; the
absolute dominant species in different tissues of C. oleifera were the
same at different levels except for soil, and there were specific
bacterial communities in roots and stems of C. oleifera. The KEGG
functional predictions revealed that endophytic bacteria were involved
in a variety of metabolic pathways, including functional information
related to human diseases. The structure and diversity of endophytic
bacterial communities in different niches of C. oleifera showed a
bottom-up filtering selection mechanism, and the bacterial communities
in different niches differed significantly in structure and functional
information, providing favourable information for the functional use of
endophytic bacteria and the exploitation of new beneficial microbial
resources, which is worth further research and exploitation.
Accelerated durability evaluation of steering knuckle under fatigue loading
Authors: Zhou Yifu , Li He , Luo Zhong
Published: August 2022

Accelerated durability evaluation aims to quantify the fatigue damage of
components in a shorter time. The quality of accelerated editing
directly affects the evaluation’s efficiency and accuracy. This paper
proposes an accelerated spectrum editing method based on the multiaxial
rainflow counting theory, then derives an equivalent fatigue damage
model for the components. Take the steering knuckle of a passenger car
as the research object, the fatigue damage caused by the original and
the accelerated spectrums are evaluated by the proposed method. The
evaluation results show that the proposed method has apparent advantages
in compression efficiency, damage consistency, and retaining the
frequency domain impact on the component. The research of this paper can
provide a theoretical and practical reference for accelerated fatigue
testing.
A capable numerical meshless scheme for solving distributed order time-fractional reaction-diffusion equation
Authors: Hesameddini Esmail , Habibirad Ali , Azin Hadis
Published: August 2022

Distributed order fractional differential equations are efficient in
describing physical phenomena because of the differential order
distribution. In this paper, the distributed order time-fractional
reaction-diffusion equation is considered in the sense of Caputo
fractional derivative. A hybrid method is developed based on the Moving
Kriging (MK) interpolation and finite difference method for solving this
distributed order equation. First, the distributed integral is
discretized by the $M$-point Gauss Legendre quadrature rule. Then, the
$L2-1_{\sigma}$ method is applied to approximate the
solution of the fractional derivative discretization. Also, the
unconditionally stability and rate of convergence
$O(\tau^{2})$ of the time-discrete technique are
illustrated. Furthermore, the MK interpolation is applied in the space
variables discretization. Finally, some examples are presented to
indicate the efficiency of this method and endorsement the theoretical
results.
¿Cómo viaja la luz? La actividad experimental para desarrollar competencias científicas en la infancia
Authors: García Gaitán Claudia Carolina , Ramírez Díaz Mario Humberto , Arriaga Santos Carlos Adrián
Published: August 2022

En México, en el nivel de primaria se espera que los estudiantes comprendan fenómenos físicos, entre los que se encuentra la luz y sus interacciones. Esto representa un desafío debido a que, durante la formación inicial docente, los contenidos alusivos a la física no están incluidos en el mapa curricular. Las implicaciones se observan en el aprendizaje de los estudiantes de este nivel, porque les es complejo explicar desde la perspectiva científica los fenómenos y procesos naturales. El objetivo de esta investigación fue analizar el nivel de logro de la competencia: comprensión de fenómenos y procesos naturales desde la perspectiva científica, mediante la aplicación de una actividad experimental relacionada con la trayectoria de la luz. Se trató de un estudio de caso, a través de un enfoque cualitativo. Los participantes fueron 59 alumnos de 8 a 10 años de edad que cursan el nivel de educación primaria. En los resultados se reconoce la necesidad de la actividad experimental para promover el desarrollo de competencias científicas en la infancia. La importancia de favorecer la reflexión de la observación para la construcción de explicaciones de lo que ocurre en el entorno y la construcción de significados para el conocimiento científico.
Cirurgia periodontal guiada – fluxo digital para correção de sorriso gengival
Authors: Mezzadri Jessica , Silva Kelly , de Moraes Gabriela Fracasso , Manfron Ana Paula Tulio
Published: August 2022

To promote an effective and predictable treatment planning in cases of gingival smile correction, a periodontal surgical guided from virtual planning could be used. The guide was designed using planning software, based on the patient’s facial aesthetic analysis, photos and intraoral scanning. The present case report describes a gingival smile correction, using digital planning combined with high-power diode laser for periodontal surgery. After 16 months of preservation, there was less exposure of the gingiva in the smile and a high level of patient aesthetic satisfaction. Considering the importance of the correct treatment planning, it may be concluded that use of surgical guided made from a digital planning provided a predictable, personalized and safe treatment to the patient.
PENGARUH INVESTASI AKTIVA TETAP, MODAL KERJA DAN UKURAN PERUSAHAAN TERHADAP PROFITABILITAS PADA PT. CHAROEN POKPHAND INDONESIA TBK
Authors: Hardana Ali , Gautama Budi , Annam Rahmat
Published: August 2022

This research was conducted at PT. Charoen Pokphand Indonesia Tbk. Background problems in this study are fluctuations and phenomena of investment in fixed assets, working capital and company size to profitability in the period 2012-2019 at PT. Charoen Pokphand Indonesia Tbk. In this study showed that not every empirical event corresponds to the existing theory. Where the theory states that if the asset investment remains high then profitability is high but the opposite is true. If working capital is high then profitability is high but the opposite is true. If working capital is high then profitability is high but the opposite is true. The purpose of this study is to determine the effect of investment in fixed assets, working capital and company size on profitability in PT. Charoen Pokphand Indonesia Tbk. The theory used in this study is the theory of investment in fixed assets, working capital, company size, and profitability. This type of research is a type of quantitative research using secondary data. The analysis used is descriptive statistical analysis, normality test, classical assumption test, multiple linear regression analysis, hypothesis test, and coefficient of determination (R^2) with data processing using SPSS software version 26. The results showed that the investment in fixed assets partially did not affect the profitability of PT. Charoen Pokphand Indonesia Tbk. Working capital partially does not affect the profitability of PT. Charoen Pokphand Indonesia Tbk. The size of the company partially affects the profitability of PT. Charoen Pokphand Indonesia Tbk. Simultaneously, the investment in fixed assets, working capital and the size of the company affects the profitability of PT. Charoen Pokphand Indonesia Tbk.
PENERAPAN DIGITALISASI KOLEKSI ETNOGRAFIKA UNTUK MENINGKATKAN JUMLAH PENGUNJUNG PADA MUSEUM NAGARI DR. SAWIRMAN DI NAGARI TOBOH GADANG KABUPATEN PADANG PARIAMAN
Authors: Sawirman Sawirman
Published: August 2022

Fungsi museum saat ini bukan hanya sekadar tempat penyimpanan koleksi, tetapi juga sebagai sarana untuk pembelajaran, penelitian, dan bisnis. Untuk mewujudkan fungsi tersebut, saya membuat 32 poster koleksi salah satu museum yang terlatek di Nagari Toboh Gadang, Kecamatan Sintuk Toboh Gadang, Kabupaten Padang Pariaman, Sumatra Barat. Museum tersebut dinamakan Museum Nagari Dr. Sawirman atau terkadang hanya disingkat dengan Museum Nagari dalam artikel ini. Metode research and development digunakan. Saya membuat 32 poster dan situs Museum Nagari sebagai media pembelajaran dan penelitian tahun 2021. Poster-poster tersebut selain dipajang secara manual di dalam museum juga ditampilkan di website https://sawirman.com/museum/. Poster-poster tersebut mencantumkan nomor registrasi, nomor inventarisasi, nama artefak dalam bahasa daerah, bahasa Indonesia, nomor inventarisasi, jenis, subtipe, panjang, lebar, diameter, asal, bahan artefak, keterangan, tanggal pendaftaran, dan nama penyedia (penjual artefak atau penyumbang koleksi museum). Semua poster itu telah memiliki hak cipta sejak bulan Desember 2021. Berhubung beberapa konten dalam situs tersebut memiliki hak cipta dari Direktur Jenderal Kekayaan Intelektual, Paten dan Merek Kementerian Hukum dan Hak Asasi Manusia Republik Indonesia, pembaca tidak diperbolehkan mengunduh dan mengutip informasi kecuali sumbernya disebutkan dalam kutipan secara benar. Output lainnya adalah profil buku Museum Nagari dan sertifikat pemateri kunci.
Photoactive surfactant semiconductors characterized by a dissociative identity disorder integrated into the membranes of living cells as trojan horses for on-demand and spatial regulation of oxidative stress.
Authors: Jaschke Marian , Plenge Masina , Kunkel Marius , Lehrich Tina , Schmidt Julia , Stöckemann Kilian , Heinemann Dag , Siroky Stephan , Ngezahay Anaclet , Polarz Sebastian
Published: August 2022

Oxidative stress is a cause for numerous diseases and aging processes. Thus, one is keen to tune the level of intracellular stress and to learn from that, and an unusual approach is presented here. The methodology involves multifunctional surfactants. Although their molecular design is non-biological, a fullerenol head group attached covalently to -conjugated dyes, the surfactants possess superior biocompatibility. Using the intrinsic fluorescence signal as a probe it is proven, the amphiphiles become incorporated into the membranes of Caco-2 cells. There, they are able to exhibit additional functions. The compound reduces cellular stress in dark reaction pathways. The antagonistic property is activated under irradiation, the photocatalytic production of ROS, resulting in cell damage and finally to apoptosis. The feature is activated even by NIR-light via a two-photon process. The properties as molecular semiconductors leads to a trojan horse situation and allows programming the spatial distribution of cytotoxicity.
One-dimensional fragments of fullerene C60 that exhibit robustness toward multi-electron reduction and pronounced light absorption
Authors: Hayakawa Masahiro , Sunayama Naoyuki , Takagi Shu I. , Tamaki Asuka , Yamaguchi Shigehiro , Fukazawa Aiko
Published: August 2022

Fullerenes are compelling molecular materials owing to their exceptional robustness toward multi-electron reduction. Although scientists have attempted to address this feature by synthesizing various fragment molecules, the origin of this electron affinity remains unclear. Several structural factors have been suggested, including high symmetry, curved structures, and five-membered ring substructures. To elucidate the role of the five-membered ring substructures without the influence of high symmetry and curved structure, we herein report the synthesis and electron-accepting properties of oligo(biindenylidene)s, a one-dimensional fragment of fullerene C60. Electrochemical studies corroborated that oligo(biindenylidene)s accept electrons equal to the number of five-membered rings in their main chains. Moreover, ultraviolet/visible/near-infrared absorption spectroscopy revealed that oligo(biindenylidene)s exhibit significantly enhanced absorption covering the entire visible region in relation to C60. These results highlight the significance of the pentagonal substructure for attaining stability toward multi-electron reduction and provide a new strategy for the molecular design of electron-accepting -conjugated hydrocarbons.
Revisiting phase transformation mechanisms in LiNi0.5Mn1.5O4 high voltage cathodes with operando microdiffraction
Authors: Martens Isaac , Vostrov Nikita , Mirolo Marta , Colalongo Mattia , Kus Peter , Richard Marie-Ingrid , Wang Lianzhou , Zhu Xiaobo , Schulli Tobias U. , Drnec Jakub
Published: August 2022

Understanding the phase transition mechanisms of active materials inside Li-ion batteries is critical for rechargability and optimizing the power/energy density of devices. In this work, high-energy microfocused X-ray diffraction is used to measure in operando the state-of-charge heterogeneities inside a high-voltage spinel (LiMn1.5Ni0.5O4, LMNO) cathode. The structure of active material which resists complete delithiation is studied, towards unlocking the full storage capacity of ion-conductive spinels. High-precision diffraction also reveals nonlinear coupling between strain and lithiation state inside the cathode at high voltages, which suggests the phase diagram of this material is more complex than previously assumed. X-ray diffraction depth-profiling shows that large lithiation heterogeneities through the cross-section of the electrode are formed even at low currents, and that decoupling these gradients are necessary to study the phase transitions in detail.
Insight into ortho-boronoaldehyde conjugation via a FRET-based reporter assay
Authors: Rose Nicholas , Tipple Eve , Sanchez Anais , Lynam Jason , Spicer Christopher
Published: August 2022

Ortho-boronoaldehydes react with amine-based nucleophiles with dramatically increased rates and product stabilities, relative to unfunctionalised benzaldehydes, leading to exciting applications across biological and material chemistry. We have developed a novel Förster resonance energy transfer (FRET)-based assay to provide key new insights into the reactivity of these boronoaldehydes, allowing us to track conjugation with unprecedented sensitivity and accuracy under standardised conditions. Our results highlight the key role played by reaction pH, buffer additives, and boronoaldehyde structure in controlling conjugation speed and stability, providing design criteria for further innovations and applications in the field.
Understanding Mechanisms of All-solid-state Lithium-Sulfur Batteries through Operando Raman and Ex-situ XAS Studying
Authors: Sun Xiao , Cao Daxian , Bak Seong-Min , Ji Tongtai , Du Yonghua , Geiwitz Michael , Burch Kenneth , Zhu Hongli
Published: August 2022

All-solid-state lithium-sulfur batteries (ASLSBs) have been considered a promising next-generation energy storage technology due to their remarkable safety and high energy density. In ASLSBs, the electrochemical pathways are intrinsically different from conventional Li-S batteries using liquid electrolytes. However, the mechanism still lacks clear identification and deep understanding. Herein, for the first time, we investigated the chemistries and explored the electrochemical reaction mechanism and kinetic in ASLSBs through coupling operando Raman spectroscopy and ex-situ X-ray absorption spectroscopy. We proved no long-chain lithium polysulfides (Li2Sn, 4≤n≤8) were formed during the redox reactions, but a short-chain polysulfide (Li2S2) intermediate phase formation was identified in the conversion between active material S8 and reduction product Li2S. The existence of intermediate phase Li2S2 results in low sulfur utilization and poor battery performance. In comparison to liquid cells, ASLSBs exhibit sluggish reaction kinetics due to the higher conversion barrier and slower charger transfer in solid-solid reactions. This study revealed the generation of Li2S2 intermediates in ASLSBs, inspiring future research to further improve the performance of ASLSBs through completing the conversions and promoting reaction kinetics in ASLSBs.
Repercussions of the COVID-19 pandemic on breast cancer treatment in a referral hospital in Santos-SP, Brazil
Authors: Sousa Emily Brenda de Lima , Kasa Marina Antunes , Rosado Rafaela Cristina Trigueiro , Marques Tatiana Carvalho , Piccinalli Marina Filié Haddad
Published: August 2022

Objective: Considering that breast cancer has the fifth highest mortality rate in the world, this study aims to evaluate the repercussions of the COVID-19 pandemic on the treatment, both surgical and systemic, of patients with cancer in general and those with breast cancer at Hospital Guilherme Álvaro (Santos, Brazil), between March 1st, 2019 and February 28, 2021. Methods: For this purpose, data were collected from both the hospital’s surgery record book and electronic medical records of patients who were followed up in the Mastology and Oncology sectors at Hospital Guilherme Álvaro. This information was tabulated, estimating the total number of surgeries, whether: benign elective surgeries, diagnostic surgeries, surgeries of cancer in general, surgeries exclusive to mastology, of cancer in mastology, benign surgery in mastology, and plastic reconstructive surgery. The percentage ratio between these numbers was calculated. Results: A 49% reduction in total surgeries was observed, comparing the period prior to the pandemic (2019–2020) with the pandemic period (2020–2021), with a decrease of 24.6% in the number of general cancer surgeries except for mastology, and 19.6% of surgeries exclusive to mastology. In other words, there was a total reduction of 22.9% in all oncological surgeries. Moreover, there was a decrease of 11.5% in the total number of patients treated with chemotherapy. In 2020, of the 214 new cases, 116 (54.2%) were mastology patients, being 45.8% of other oncology clinics. Conclusion: Thus, it is concluded that the reduction in the number of aesthetic, benign, and reconstructive surgeries was expected, as observed in the decrease in the number of chemotherapies, which could be due to a limitation on medical appointments. The number of diagnostic surgeries remained stable, which could lead to positive outcomes for oncology patients. It is not possible to predict the next repercussions of the COVID-19 pandemic on breast cancer treatment while the pandemic endures, requiring more studies on this topic.
KONSUMSI GORENGAN DAN ASUPAN KOLESTEROL BERHUBUNGAN DENGAN KEJADIAN HIPERKOLESTEROLEMIA PADA MAHASISWA
Authors: Yuningrum Hesti , Rahmuniyati Merita Eka , Lende Theresia Dwi Putri
Published: August 2022

ABSTRAKDi Indonesia proporsi kolesterol abnormal pada penduduk umur ≥15 tahun menurut jenis kelamin yaitu sebesar 69,6% angka ini menunjukkan proporsi kolesterol abnormal. Faktor yang dapat menyebabkan hiperkolesterolemia salah satunya adalah konsumsi makanan tinggi lemak seperti konsumsi gorengan.  Proporsi nasional penduduk dengan perilaku konsumsi makanan yang berlemak, makanan berkolesterol, dan makanan gorengan lebih dari sama dengan 1 kali per hari sebesar 40,7%. Tujuan penelitian ini mengetahui hubungan konsumsi gorengan dan asupan kolesterol dengan kejadian hiperkolesterolemia pada mahasiswa kesehatan masyarakat di Universitas Respati Yogyakarta. Jenis penelitian bersifat kuantitatif dengan rancangan  cross sectional. Teknik sampling  yaitu purposive sampling dengan jumlah sampel 67 orang. Data konsumsi gorengan dan asupan kolesterol diperoleh menggunakan Semi quantitative food frequency questionnaire (SQFFQ). Kadar kolesterol total diperoleh menggunakan rapid test kolesterol (easy touch). Analisis data yang digunakan yaitu univariat dan bivariat dengan uji Chi Square. Hasil analisis bivariat menunjukkan konsumsi gorengan (p-value=0,026, RP=2,206, CI=1,133-4,296) dan asupan kolesterol (p-value=0,037, RP=2,530, CI=0,959-6,647) mempunyai risiko terhadap kejadian hiperkolesterolemia. Kesimpulannya konsumsi gorengan dan asupan kolesterol berhubungan dengan hiperkolesterolemia sehingga di sarankan pada mahasiswa untuk mengurangi makanan gorengan dan perbanyak makan sayur dan buah.Kata Kunci: hiperkolesterolemia, konsumsi gorengan, asupan kolesterol, mahasiswa
Unsteady Magnetohydrodynamic (MHD) flow past an accelerated vertical plate in the presence of thermal radiation and chemical reaction
Authors: Abubakar Shehu  , Ibrahim Danjuma Yale  , Abdulazeez Mohammed Tanko Uchiri
Published: August 2022

A study on Magnetohydrodynamic (MHD) flow past an accelerated vertical plate with the effects of thermal radiation and chemical reaction has been carried out. The dimensionless governing equations are solved using Laplace transform technique. The solution for the velocity, temperature and concentration field are obtained and analyzed for the different physical parameters like thermal Grashof Number, Modified Grashof Number, permeability parameter, Prandtl Number, Radiation parameter, Schmidt Number, chemical reaction parameter and time. It is observed that the velocity profile increases with increasing parameters like, Sc, Gc, M, R and t and also decrease with the decreases Pr and Gr. the temperature profile shows the decrease with the decreasing in Pr and t. and increase in R. While the concentration profile shows the increase in alpha and decrease in Sc and t.
Kinetics of Cucurbita Moschata Puree Drying with Maltodextrin as Drying Aid
Authors: Hartati Indah , Setiawati Salsa Erna , Suwardiyono  , Maharani Farikha , Faizin Safaah Nur
Published: August 2022

The objective of this research was to investigate the influence of maltodextrin addition of pumpkin puree drying as well as studied the drying kinetics. Several thin layer drying kinetics model comprised of Page, Lewis, Henderson Pabis, Two Term, Weibull as well as diffusion model were used to studied the behavior of pumpkin drying. The puree drying was conducted by added 15% of maltodextrin on pumpkin puree. The drying temperatures were varied of 60-70  The research result show that temperature influence the pumpkin puree drying in which added with maltodextrin as the drying aid. Pumpkin puree drying with addition of maltodextrin performed at temperature of 70  for 150 minutes is considered as the relatively suitable condition as it gives low moisture ratio of 0.07. The thin layer drying kinetics, Midili, give good fittest to the experimental data followed by Page and Weibull. The effective diffusivity is in range of  m/s with the obtained activation energy is 30.36 kJ/mol.
Root Cause Analysis
Authors: Burgess David
Published: August 2022

This columnn explores the idea that insights into the root cause of increasingly complex failures may be hidden in unanswered questions from past analyses, indicating that there might be more value in previous files than once thought.
A Biologically Inspired Approach to Interception
Authors: Chance Frances S.
Published: August 2022

This article presents a control model that may have application to automated wafer-level die testing and characterization. Mimicking the behavior of a dragonfly in pursuit of prey, the model implements a form of proportional navigation that optimizes interception trajectories based on feedforward error signals derived from image data.
Defect Characterization of Advanced Packages using Novel Phase and Dark Field X-Ray Imaging
Authors: Lau S.H. , Gul Sheraz , Zan Guibin , Vine David , Lewis Sylvia , Yun Wenbing
Published: August 2022

Modified Talbot X-ray interferometry provides three contrast modes simultaneously: absorption, phase, and dark field/scattering. This article describes the powerful new imaging technique and shows how it is used to characterize various types of defects in advanced semiconductor packages.
The EDFAS FA Technology Roadmap—Advancing Our Community
Authors: Antoniou Nicholas
Published: August 2022

Failure analysis has become a critical enabler of semiconductor technology innovations. Logic and memory scaling continues at an unabated pace with new materials and transistor architectures being introduced. The integration of advanced packaging technologies like chiplets, 2.5D, and 3D in mainstream devices is exploding. To address these challenges, a new industry-wide FA Technology Roadmap was created and approved by the EDFAS Board in 2020. This column discusses the planned next steps in the Roadmap project.
Influence of parental factors on upper basic students’ performance in Social and Islamic Studies in Ilorin, Nigeria
Authors: Olokooba Issa Nasiru , Owoyale-Abdulganiy Ibrahim Solahudeen
Published: August 2022

Parenting is the process of promoting and supporting the physical, emotional, social, and intellectual development of a child from infancy to adulthood. The study therefore examined the influence of parental factors on upper basic students’ academic performance in Social and Islamic Studies in Ilorin, Nigeria. A descriptive survey research design was adopted for the study. The sample for this study was all upper basic Social and Islamic Studies students in Ilorin. Systematic random sampling was employed to select seven upper basic schools in Ilorin. Purposive sampling technique was used to select 180 upper basic 2 Social and Islamic Studies students. A Pro-Forma was used as the instrument for data collection. Data analysis was done using ANOVA and Scheffe-Post Hoc analysis for research hypotheses. The result of the study showed that there was a significant difference in the academic performance of upper basic students’ in Social and Islamic Studies based on parental educational level and Socio-economic Status, the parental educational level. The finding of the study revealed that there was no significant difference in the academic performance of upper basic students’ in Social and Islamic Studies based on parental occupation and marital status. Based on these findings, it was recommended among other that parents should create enough time with their children especially in the area of communication concerning school activities, expectations of academic performance, the importance of achieving good results and they should always ask, and give encouragement to the children about the importance of homework.
IMPLEMENTASI PERLINDUNGAN HUKUM KONSUMEN DALAM TRANSAKSI JUAL BELI ONLINE
Authors: Ilma Imami Rosida  , Herwin Sulistyowati
Published: August 2022

Seiring perkembangan teknologi kegiatan bisnis online saat ini sering dimanfaatkan banyak orang, sehingga timbul adanya konflik antara penjual dan pembeli terkait transaksi online. Tujuan penelitian ini; Untuk mengetahui implementasi perlindungan hukum konsumen dalam transaksi jual beli online berdasarkan Undang-Undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen (UUPK), dan untuk mengetahui faktor yang menghambat dalam pelaksanaan perlindungan hukum konsumen dalam transaksi jual beli online. Metode penelitian, yaitu yuridis empiris didukung data normatif.Pendekatan penelitian yaitu kualitatif, teknik analisis data yaitu reduksi data, penyajian data, kesimpulan. Hasil penelitian, bahwa UUPK dan UU No.19 Tahun 2016 tentang informasi dan transaksi elektronik (UUITE) agar konsumen bisa aktif agar konsumen yang ingin mengeluh, datang ke kantor LPKSM untuk konsultasi. Jika konsumen memberi kuasa kepada LPKSM, LPKSM kemudian membuat surat kuasa yang ditandatangani dan disetujui oleh konsumen LPKSM, tindakan yang dilakukan terlebih dahulu dengan upaya kekeluargaan. Faktor-faktor yang menghambatperlindungan hukum konsumen dalam transaksi jual beli online yaitu; Pemerintah kurang responsif terhadap perkembangan masyarakat dalam transaksi elektronik, tidak adanya peraturan yang secara teknis memberikan perlindungan kepada konsumen terhadap adanya transaksi online, pelaku usaha dan konsumen tidak memahami hak dan kewajibannya. Kesimpulan dari penelitian ini, LPKSM sebagai perpanjangan dari pemerintah telah aktif namun tidak ada kebijakan yang secara teknis mengatur dan melindungi konsumen dalam transaksi online, faktorfaktor yang menghambat adalah pemerintah yang kurang responsif, ketidaktahuan terhadap Konsumen dan pelaku usaha terkait hak dan kewajibannya.
LEGAL TECHNOLOGY AS A SCIENTIFIC DIRECTION IN NATIONAL JURISPRUDENCE
Authors: Березина Елена Александровна
Published: August 2022

In the modern world, more and more attention is paid to the problems of social technologies both in the field of science and in the field of practical activity. A distinct type of social technologies is legal technology, which can be considered, firstly, as a purposeful activity carried out through legal means, aimed at changing legal reality, secondly, as a certain scientific direction of legal research, thirdly, as an academic discipline. The purpose of the study is to substantiate the need to consider legal technology as a scientific direction in national jurisprudence, identifying its features as a system of knowledge, defining the object, subject and method of legal technology, considering the principles and functions of legal technology as an independent scientific direction. Research methods: to achieve this goal, philosophical methods (dialectical logic), general scientific methods (formal logic, structural-functional, systemic, historical methods), specific scientific methods (sociological, linguistic) and special legal methods (formal legal, legal forecasting, interpretation of law) are used. Results: the conducted research allows us to conclude that legal technology as a system of interrelated knowledge has specific features of a substantive, methodological, functional nature; it has a system of its own characteristics and principles, which allows it to be considered as an independent direction of scientific knowledge. Legal technology is a scientific direction that studies the processes of purposeful influence on social relations, exercised by legal entities in a special way, with the help of special legal means to achieve the predicted (planned) legal results.
Comprehensive bibliometric analysis of sirtuins: Focus on sirt1 and kidney disease
Authors: Liu Tongtong , Mu Shujuan , Yang Liping , Mao Huimin , Ma Fang , Wang Yuyang , Zhan Yongli
Published: August 2022

Sirtuins, as regulators of metabolism and energy, have been found to play an important role in health and disease. Sirt1, the most widely studied member of the sirtuin family, can ameliorate oxidative stress, immune inflammation, autophagy, and mitochondrial homeostasis by deacetylating regulatory histone and nonhistone proteins. Notably, sirt1 has gradually gained attention in kidney disease research. Therefore, an evaluation of the overall distribution of publications concerning sirt1 based on bibliometric analysis methods to understand the thematic evolution and emerging research trends is necessary to discover topics with potential implications for kidney disease research. We conducted a bibliometric analysis of publications derived from the Web of Science Core Collection and found that publications concerning sirt1 have grown dramatically over the past 2 decades, especially in the past 5 years. Among these, the proportion of publications regarding kidney diseases have increased annually. China and the United States are major contributors to the study of sirt1, and Japanese researchers have made important contributions to the study of sirt1 in kidney disease. Obesity, and Alzheimer’s disease are hotspots diseases for the study of sirt1, while diabetic nephropathy is regarded as a research hotspot in the study of sirt1 in kidney disease. NAD+, oxidative stress, and p53 are the focus of the sirt1 research field. Autophagy and NLRP3 inflammasome are emerging research trends have gradually attracted the interest of scholars in sirt1, as well as in kidney disease. Notably, we also identified several potential research topics that may link sirt1 and kidney disease, which require further study, including immune function, metabolic reprogramming, and fecal microbiota.
First genomic insights into the Mandevilla genus
Authors: Palumbo Fabio , Draga Samela , Scariolo Francesco , Gabelli Giovanni , Sacilotto Gio Batta , Gazzola Marco , Barcaccia Gianni
Published: August 2022

Mandevilla (Apocynaceae) is a greatly appreciated genus in the world ornamental market. In this study, we attempted to address the poor genetic knowledge and the huge taxonomic gaps existing in this genus by analyzing a collection of 55 accessions. After cytometrically determining the triploid genome size (1,512.64 Mb) of a reference sample (variety “Mandevilla 2001”), the plastidial genome (cpDNA, 0.18 Mb) and a draft of the nuclear genome (nuDNA, 207 Mb) were assembled. While cpDNA was effective in reconstructing the phylogenesis of the Apocynaceae family based on a DNA superbarcoding approach, the nuDNA assembly length was found to be only 41% of the haploid genome size (506 Mb, predicted based on the K-mer frequency distribution). Its annotation enabled the prediction of 37,811 amino acid sequences, of which 10,562 resulted full length proteins. Among them, we identified nine proteins whose orthologs (in Catharanthus roseus) are involved in the biosynthesis of monoterpene indole alkaloids (MIAs), including catharanthine, tabersonine, and vincadifformine. The nuclear genome draft was also useful to develop a highly informative (average polymorphism information content, PIC = 0.62) set of 23 simple sequence repeat (SSR) markers that was validated on the Mandevilla collection. These results were integrated with cytometric measurements, nuclear ITS1 haplotyping and chloroplast DNA barcoding analyses to assess the origin, divergence and relationships existing among the 55 accessions object of the study. As expected, based on the scarce information available in the literature, the scenario was extremely intricate. A reasonable hypothesis is that most of the accessions represent interspecific hybrids sharing the same species as maternal parent (i.e., Mandevilla sanderi).