bluuebunny/crossref_metadata_2025 huggingface dataset:
AIR-CONDUCTION AND BONE-CONDUCTION REFERENCE THRESHOLD LEVELS – A MULTICENTER STUDY
Authors: Margolis Robert H. , Sanchez Victoria , Hunter Lisa L. , Rao Aparna , Boyle Suzannah , Zadeh Lina Motlagh , Wong Amelia N.
Published: August 2024

Air--conduction (AC) and bone-conduction (BC) thresholds were measured to evaluate standard reference thresholds and recommend revisions to audiometer standards. AC and BC thresholds were measured from listeners with normal hearing (NH) and sensorineural hearing loss (SNHL) at three sites. NH participants (n = 53) were selected based on age (18 – 25 years), normal AC thresholds, tympanometry, otoscopy, and absence of otologic disease. SNHL participants (n = 49) were selected based on AC thresholds, tympanometry, otoscopy, and absence of otologic disease. AC thresholds obtained from NH listeners averaged 3.7 dB HL. Air bone gaps (ABGs) occurred in NH and SNHL listeners above 2000 Hz and SNHL listeners at 250 Hz. Corrections to standard RETSPLs are recommended. ABGs in listeners without conductive pathology result from incorrect reference threshold levels for frequencies above 2000 Hz. False air-bone gaps increase with hearing-loss magnitude, probably due to effects of ambient and internal noise for low-level bone-conduction stimuli. False ABGs place patients at risk for unnecessary medical and surgical intervention. Reference threshold levels should achieve two objectives: 1) AC thresholds from young NH listeners should average 0 dB HL; 2) ABGs from listeners with normal middle-ear function should average 0 dB.
Genome-wide analysis identifies 66 variants underlying anatomical variation in human neuroendocrine structures and reveals links to testosterone
Authors: Currant Hannah , Arthofer Christopher , Ferreira Teresa , Douaud Gwenaelle , Hill Barney , Venkatesh Samvida S , Baya Nikolas A , Palmer Duncan S , Reibe Saskia , Moltke-Prehn Anje , Pers Tune H , Bartsch Andreas , Andersson Jesper , Lippincott Margaret F , Chan Yee-Ming , Seminara Stephanie B , Nichols Thomas E , Nellaker Christoffer , Smith Stephen , Brunak Søren , Lange Frederik J , Lindgren Cecilia M
Published: August 2024

The hypothalamus, pituitary gland and olfactory bulbs are neuroanatom-ical structures key to the regulation of the endocrine system. Variation in their anatomy can affect the function of the reproductive system. To investigate this relationship, we extracted four largely unexplored phenotypes from 34,834 individuals within UK Biobank by quantifying the volume of the hypothalamus, pituitary gland and olfactory bulbs using multi-modal magnetic resonance imaging. Genome-wide associ-ation studies of these phenotypes identified 66 independent common genetic associations with endocrine-related neuroanatomical volumes (P <5×10−8), five of which had a prior association to testos-terone levels, representing enrichment of testosterone-associated SNPs over random chance (P-value =9.89×10−12). Exome-wide rare variant burden analysis identifiedSTAB1as being significantly associ-ated with hypothalamus volume (P= 3.78×10−7), with known associations to brain iron levels. Common variants associated with hypothalamic grey matter volume were also found to be associated with iron metabolism, in which testosterone plays a key role. These results provide initial evidence of common and rare genetic effects on both anatomical variation in neuroendocrine structures and their func-tion in hormone production and regulation. Variants associated with pituitary gland volume were enriched for gene expression specific to theca cells, responsible for testosterone production in ovaries, suggest-ing shared underlying genetic variation affecting both neuroanatomical and gonadal endocrine tissues. Cell-type expression enrichment analysis across hypothalamic cell types identified tanycytes to be associated (P= 1.69×10−3) with olfactory bulb volume associated genetic variants, a cell type involved in release of gonadotropin-releasing hormone into the bloodstream. Voxel-wise analysis highlighted associations between the variants associated with pituitary gland volume and areas of intracranial venous drainage involved in hormonal release into the blood circulation. Together, our results suggest a shared role of genetics impacting both the anatomy and function of neuroendocrine structures within the repro-ductive system in their production and release of reproductive hormones.
PRESCRIBING PRACTICES AND CLINICAL IMPACT OF NEXT GENERATION SEQUENCING IN ROUTINE PRACTICE IN SOLID TUMORS – REAL WORLD EXPERIENCE IN LMIC
Authors: Zaki Adeeba , Zehra Nida E , Sohail Aqsa , Ansar Zeeshan , Moosajee Munira
Published: August 2024

Molecular characterization of disease is essential for precision medicine due to novel predictive biomarkers. Multiple next-generation sequencing (NGS) platforms are available, but their expense and clinical utility vary. Even if a targetable mutation is detected, corresponding drugs may not be available or affordable. No prior studies in Pakistan have focused on integrating NGS results into patient care to assist with therapeutic decision-making and survival outcomes.

This retrospective study aimed to evaluate the molecular profiling and therapeutic implications of NGS testing across solid tumors. It included all patients with histologically proven malignancy (metastatic or non-metastatic) who had NGS analysis at Aga Khan University Hospital (AKUH) from June 1, 2020, to June 1, 2023. Foundation One was the NGS platform used. From 2020 to 2023, 192 patients underwent NGS. The majority were male (55.2%) and aged over 50 years (71.9%). The most common indications for NGS were carcinoma of unknown primary (CUP) and lung cancers, representing 26% and 25% respectively, followed by colon (9%) and breast cancers (8%). Most patients had metastatic disease (98.4%). Common mutations in lung cancer were EGFR (16.3%) and KRAS G12C (14.3%). In unknown primary, breast, and colon cancers, the most common mutations were BRAF (8%), PIK3CA (18%), and KRAS (42.1%), respectively. Microsatellite instability (MSI) testing was performed in 95% of patients, with 6% being MSI high. Actionable alterations were detected in 31.8% of patients, but only 17.2% received genotype-matched treatment, mostly as a first-line treatment for lung cancer. The primary barriers were drug availability and affordability.

Our results show that the implementation of NGS analysis supports clinical decision making. However, these results were applicable to a small percentage of patients. For better compliance and applicability, drug availability and cost of treatment needs to be addressed
Beyond the fields: tracing India’s labour transition from agriculture to non-agricultural sectors
Authors: Singh Pushpendra , Pattanaik Falguni
Published: August 2024

Purpose

Since the post-liberalization era, a noticeable structural change and transition in employment have unfolded within the Indian economy. Hence, the purpose of this paper is to understand employment transition and elucidate the evolving dynamics of rural economies and employment patterns from agriculture to more productive non-agricultural sectors. Additionally, the study investigates the underlying causes of socioeconomic disparities and their repercussions on employment trends.

Design/methodology/approach

To address the aforementioned issues, this study utilised secondary data from labour surveys conducted by the National Sample Survey Organisation spanning from 2004–05 to 2023. Initially, the study computed the magnitude of employment in both agriculture and non-agriculture sectors. Subsequently, the distribution of non-agricultural labour across various socioeconomic characteristics was estimated. Furthermore, a logistic regression model was employed to evaluate the impact of socioeconomic factors on employment choices. Finally, Fairlie’s decomposition model was applied to elucidate workers’ decisions to engage in non-agricultural sectors.

Findings

The study reveals a significant rise in rural non-agricultural employment, from 98.4 m in 2004–05 to 193.3 m in 2023, indicating changing job preferences. Notably, the construction and trade sectors emerge as significant drivers of this trend. However, self-employment and casual labour persist, highlighting job vulnerability. Additionally, women and marginalised individuals with low levels of education and socioeconomic status lag behind in non-agricultural employment.

Originality/value

This study makes a significant contribution by offering a thorough analysis of the employment transition from agriculture to non-agriculture over a span of two decades. It provides valuable insights into the evolving dynamics of employment trends.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-11-2023-0904.
The formation mechanism of the excessive use of short-form video apps: an IT affordance perspective
Authors: Li Wenhua , Fu Yuwo , Guo Junpeng , Mao Jiaxin
Published: August 2024

Purpose

Recently, short-form video apps, as a new form of social media, have attracted users and rapidly emerged by virtue of their personalized recommendation algorithms, interesting forms of live interaction, and diverse interactive functions, which may lead to excessive use. From the perspective of IT affordances, this study combines the cognitive-affective-behavioral model and perceived values theory to examine the formation mechanism of the excessive use of short-form video apps.

Design/methodology/approach

We surveyed a total of 351 users who have used Tiktok, a typical short-form video app, and used their questionnaires to test the research model.

Findings

Searching affordance has a positive impact on perceived information value and perceived entertainment value. Furthermore, meta-voicing, recommending, and livestreaming affordance have a positive impact on perceived information value, perceived entertainment value, and perceived social networking value, which also have a positive impact on negative affect anticipation. In addition, negative affect anticipation is significantly positively correlated with excessive use.

Originality/value

In terms of theory, this study introduces the theory of IT affordances and perceived values into the cognitive-affective-behavioral model, to the best of our knowledge, for the first time. Furthermore, it conducts situational research on the formation mechanism of excessive use of short-form video apps and makes up for the lack of studying of excessive use behavior from the perspective of technical factors.
Using ESG paradigm as a basis for social reporting in nonprofit organizations: evidence from cases in healthcare
Authors: Pratici Lorenzo , Salvatore Fiorella Pia , Fanelli Simone , Zangrandi Antonello , Milone Michele
Published: August 2024

Purpose

The purpose of this paper is to understand whether and how the Environmental, Social and Governance (ESG) paradigm can be useful in social reporting in the context of nonprofit healthcare organizations. In other words, the study deals with non-financial reporting and information, allowing external stakeholders to comprehensively evaluate the organization’s performance and behavior, investigating internal stakeholder perception over ESG paradigm application.

Design/methodology/approach

The authors used a case study approach investigating four cases among nonprofit healthcare organizations in Italy. Analyses of available primary sources have been conducted, followed by semi-structured interviews. Interviews were then transcribed and coded in a joint blinded process by all authors. More specifically, three areas have been investigated: (1) factors motivating the development of non-financial disclosure practices; (2) the rationale behind the organization’s decision to include specific topics; and (3) the future perspective on the future of non-financial disclosure within the specific sector.

Findings

ESG may serve as a suitable framework to create comparable documents that can act as benchmarks for similar institutions. However, while nonprofit organizations (NPOs) can draw inspiration from ESG, the utility of these criteria should be thoughtfully tailored to align with the organization’s mission. The ESG using as a general guide, instead of implementing it as a real tool to assess performances, emerges as a positive practice. NPOs should not focus on fulfilling ESG requirements bur rather take inspiration from them. Otherwise, the risk is an excess of focus on the formal aspect rather than on its content.

Originality/value

The study contributes to a better understanding of social and ESG’ reporting activities and approaches in the healthcare sector by describing some case studies and the effect of sustainability in the social reporting of nonprofit healthcare organizations.
Citizens’ issue priorities respond to national conditions, less so to parties’ issue emphases
Authors: SEEBERG HENRIK BECH , ADAMS JAMES
Published: August 2024

Parties strive to set the ‘terms of the debate’ in elections by selectively emphasising issue areas that enhance their popular appeal. Yet, do citizens respond to parties’ issue emphasis, or do they mainly respond to objective factors such as economic and environmental conditions, crime rates, immigration flows, and so on? We report a time‐series, cross‐sectional analyses of the relationship between the public's issue attention, parties’ issue emphases and objective national conditions across seven issue areas in 13 western publics between 1971 and 2021, finding a strong association between objective conditions and citizens’ subsequent issue attention, but weaker associations to party system issue attention. There are stronger links, however, between parties’ issue emphases and their supporters’ subsequent attention.
Is clinician reported practice in Western Australian emergency departments aligned with direct discharge pathway protocols for minor self‐limiting fractures? A multi‐centre professional survey
Authors: Truter Piers , Pelletier Irene , Coates Sophie , Giglia‐Smith Louise , Richards Karen , Mountain David , Bulsara Caroline , Spilsbury Katrina , Edgar Dale W
Published: August 2024

Objective

To determine ED clinician's current management for five common minor self‐limiting fractures (MSLF) and evaluate practice against evidence‐informed direct discharge pathway (DD) protocols.

Methods

A survey was provided to doctors, nurse practitioners and advanced scope physiotherapists working in seven metropolitan, public health EDs in Perth, Australia. The relative odds of ED location (e.g. which facility) and clinician level factors (e.g. country of initial training, years of ED experience, profession) on recommending care completely consistent with evidence informed direct discharge pathway protocols were estimated.

Results

Two hundred sixty‐two clinicians completed the survey. There was variability in practice across all sites, with most reported care assessed at 60%–76% consistency with individual elements of DD care provision. Highest consistency was seen in lower limb immobilisation and DVT prophylaxis. Lowest consistency was seen in weight bearing advice, pain management and (boxer's) fracture reduction and immobilisation. There were very low levels of complete consistency, ranging from 9% (boxer's fracture) to 25% (radial head fracture). Two factors were associated with increased odds of completely consistent care: (i) clinician experience working in ED, with greater duration of practice associated with increased odds ratios (OR range, 1.6–3.3); and (ii) profession, where advanced scope physiotherapy was associated with increased odds ratios (OR range, 3.2–25.0).

Conclusions

Survey results suggested system wide variation in ED fracture management practice and target areas for service improvement. Avenues for service improvement could include hospital wide agreed management plans for specific fractures and support for less experienced clinicians.
First report of an Ivorian family with nonsyndromic hearing loss caused by GJB2 compound heterozygous variants
Authors: Toure Madoussou , Amalou Ghita , Raise Imane Ait , Mobio N'kan Max Ange , Malki Abderrahim , Barakat Abdelhamid
Published: August 2024

The primary etiology of congenital hearing loss is attributed to genetic factors, with GJB2 identified as a pivotal gene across diverse ethnic groups. Additionally, nonsyndromic hearing loss is predominantly inherited in an autosomal recessive manner. We used Sanger sequencing to analyze GJB2 in 17 deaf children from 13 unrelated Ivory Coast families. One family had two children born with severe congenital deafness and exhibited pathogenic compound heterozygous variants. These variants included a nonsense substitution (c.132G > A or p.Trp44Ter) and a newly discovered duplication of 7 base pairs (c.205_211dupTTCCCCA or p.Ser72ProfsTer32). Segregation testing confirmed these variants, marking the first identification of GJB2 in an Ivorian family with congenital hearing loss.
The fatigue responses of 3D‐printed polylactic acid (PLA) parts with varying raster angles and printing speeds
Authors: Horasan Murat , Sarac Ismail
Published: August 2024

In this study, the fatigue behavior of FDM‐3D printed polylactic acid (PLA) materials was investigated by rotary bending fatigue tests and finite element studies with varying printing speed and raster angle parameters. Fatigue test specimens were manufactured at five different raster angles (0°, 30°, 45°, 60°, and 90°) and two different printing speeds (20 and 80 mm/s). The effect of printing speed was evaluated at high print speed variation range (20 and 80 mm/s print speeds). It was noticed that the change in raster angle affects the fatigue life very significantly. The highest fatigue life was obtained at 30° raster angle, while the lowest fatigue life was found at 90° raster angle. Increasing the printing speed from 20 to 80 mm/s decreased the fatigue life of all specimens. The derived results from the finite element analyses were consistent with the experimental results.
Algorithmic Embeddedness and the ‘Gig’ Characteristics Model: Examining the Interplay between Technology and Work Design in Crowdwork
Authors: Bellesia Francesca , Mattarelli Elisa , Bertolotti Fabiola , Sobrero Maurizio
Published: August 2024

This article systematically reviews the literature on online task crowdwork to investigate the complex relationship between technology and work design on crowdwork platforms. We highlight the diverse interpretations and uses of technology, specifically platform features and algorithms, in relation to work design. Our review reveals that platform features serve as antecedents to work design characteristics, while algorithms are so intertwined with job execution that a new work characteristic is needed to model this interplay. We introduce this new work characteristic as algorithmic embeddedness and show that it varies in degree. When high, algorithmic embeddedness can be perceived as either an affordance or a constraint; when low, it has a limited impact on crowdworkers' jobs. Our ‘gig characteristics model’ expands previous work design theories and offers a framework for understanding the design of contemporary jobs that rely highly on algorithms. To refine our model and better understand crowdwork dynamics, we provide an agenda for future research directions.
Characterization of oral biomarkers during early healing at augmented dental implant sites
Authors: Tavelli Lorenzo , Barootchi Shayan , Rodriguez Maria Vera , Sugai Jim , Wu David T. , Yu Ning , Giannobile William V.
Published: August 2024

Aim

The aim of this study is to assess early wound healing expression of local angiogenic biomarkers following connective tissue graft (CTG) at dental implant sites.

Methods

Twenty‐eight subjects with single dental implants exhibiting a soft tissue dehiscence were included and randomly treated with CTG, either with coronally advanced flap (CAF) or with tunnel technique (TUN). Peri‐implant crevicular fluid (PICF) was collected at the midfacial and midlingual aspect of the implant sites at baseline and at 3, 7, 14, 30, and 90 days after the surgical intervention. The expression of angiogenin (ANG), fibroblast growth factor‐2 (FGF‐2), platelet‐derived growth factor (PDGF), tissue inhibitor of metalloproteinases‐2 (TIMP‐2), and vascular endothelial growth factor (VEGF) was investigated over a period of 3 months. Patient‐reported outcomes, clinical measurements, and ultrasonography scans at multiple time points were also evaluated.

Results

The longitudinal regression revealed a significant difference in the expression of VEGF and TIMP‐2 between CAF‐ and TUN‐treated sites over 3 months (p = .033 and p = .004, respectively), whereas no significant differences were observed for ANG, FGF‐2 and PDGF between the two groups. At 7 days, a direct correlation was observed between ANG levels and ultrasonographic color velocity in the CAF group (p < .001) and between ANG levels and ultrasonographic color power in the TUN group (p = .028). VEGF levels and ultrasonographic mean perfused area of the CTG were significantly correlated at the 7‐day time point (p < .001 for both CAF and TUN). The expression of VEGF at 7 days was directly associated with mucosal thickness gain at 1 year (p < .001 for both groups). Early TIMP‐2 expression showed an inverse correlation with time to recovery (p = .002). TIMP‐2 levels at 3 months exhibited inverse correlations with mean dehiscence coverage (p = .004) and the rate of complete dehiscence coverage (p = .012).

Conclusion

PICF biomarkers can be used to monitor early wound healing events following soft tissue grafting at implant sites. VEGF and TIMP‐2 showed correlations with the 1‐year clinical and volumetric outcomes, as well as with post‐operative patient‐reported outcomes and Doppler Ultrasonographic tissue perfusion‐related parameters.
Impact of liminality and rituals on professional identity formation in physician training
Authors: Hong Jian‐Hua , Chu Chun‐Lin , Tsai Daniel Fu‐Chang , Liao En‐Chi , Yeh Huei‐Ming
Published: August 2024

Purpose

The transition from medical student to practicing physician affects the complex processes of professional identity formation and professionalism, which have a lasting effect on the physician's career development. This study explored two different transitional processes of medical students in Taiwan, the associated rituals during this transitional period (the ‘liminal phase’) and their effect on the formation of professional identity.

Method

Using snowball sampling, we recruited 13 medical students from two training systems: six from the traditional postgraduate year programme and seven from the accelerated postgraduate year (A‐PGY) programme. Semi‐structured interviews were thematically analysed to identify significant themes that encapsulated trainees' experiences. A consistent and mutually confirmed discussion ensured the identification of robust recurring themes.

Results

A comparative analysis of the two training modalities provided critical insights into the relative impact of the training dynamics. The A‐PGY cohort, subjected to an altered ‘incorporation’ ritual, encountered an influx of unexpected symbolic social power, complicating their transformation within the liminal phase. Without a defined internship like in the PGY system, A‐PGY trainees exhibited confusion and inconsistencies in professional identity formation marked by conflicting internal and external perceptions. This ambiguity affected their clinical training, social integration and overall development of professionalism. The absence of a structured, sequential liminal phase increased conflict and diminished motivation, culminating in an incomplete self‐crafting journey for A‐PGY trainees.

Conclusions

This study highlights the impact of the well‐sequenced implementation of rituals in liminality on professional identity formation. A good transition training programme for medical students should compass sequential rituals in the liminal phase, including clear starting and ending points, supervision by seniors, guided reflection and plenty of opportunities for observation and imitation in context. Optimal training and pivotal elements in a medical training system warrant delicate design and further research when developing and changing the structure of the training programme.
Giant nonlinear optical wave mixing in a van der Waals correlated insulator
Authors: Yue Li , Liu Chang , Han Shanshan , Hong Hao , Wang Yijun , Liu Qiaomei , Qi Jiajie , Li Yuan , Wu Dong , Liu Kaihui , Wang Enge , Dong Tao , Wang Nanlin
Published: August 2024

Optical nonlinearities are one of the most fascinating properties of two-dimensional (2D) materials. While tremendous efforts have been made to find and optimize the second-order optical nonlinearity in enormous 2D materials, opportunities to explore higher-order ones are elusive because of the much lower efficiency. Here, we report the giant high odd-order optical nonlinearities in centrosymmetric correlated van der Waals insulator manganese phosphorus triselenide. When illuminated by two near-infrared femtosecond lasers, the sample generates a series of profound four- and six-wave mixing outputs. The near-infrared third-order nonlinear susceptibility reaches near the highest record values of 2D materials. Comparative measurements to other prototypical nonlinear optical materials [lithium niobate, gallium(II) selenide, and tungsten disulfide] reveal its extraordinary wave mixing efficiency. The wave mixing processes are further used for nonlinear optical waveguide with multicolor emission. Our work highlights the promising prospect for future research of the nonlinear light-matter interactions in the correlated 2D system and for potential nonlinear photonic applications.
Multiple origins of extra electron diffractions in fcc metals
Authors: Walsh Flynn , Zhang Mingwei , Ritchie Robert O. , Asta Mark , Minor Andrew M.
Published: August 2024

Diffuse intensities in the electron diffraction patterns of concentrated face-centered cubic solid solutions have been widely attributed to chemical short-range order, although this connection has been recently questioned. This article explores the many nonordering origins of commonly reported features using a combination of experimental electron microscopy and multislice diffraction simulations, which suggest that diffuse intensities largely represent thermal and static displacement scattering. A number of observations may reflect additional contributions from planar defects, surface terminations incommensurate with bulk periodicity, or weaker dynamical effects.
Lattice simulations for charm
Authors: Padmanath M.
Published: August 2024

In this report, I discuss some of the most recent lattice spectroscopy calculations of hadrons and hadronic resonances involving charm quarks, with special emphasis on those that are relevant from an experimental perspective.
Trichloroethylene: An Update on an Environmental Contaminant with Multiple Health Effects
Authors: Lash Lawrence H.
Published: August 2024

The halogenated solvent trichloroethylene (TCE) has had many uses in medicine, construction, consumer products, and the military. Many of these uses have been discontinued or restricted due to its toxicity, which affects multiple target organs and includes both acute, high-dose toxicity and chronic, low-dose toxicity that also encompass several cancers. US and international agencies have conducted risk and hazard assessments for TCE, with comprehensive publications coming out in the last 10–15 years. Accordingly, the focus of this article is to review recently published data since that time (i.e., 2014) that clarify unsettled questions or provide additional insights into the metabolism and mechanisms of toxicity of TCE in several target organs. Besides metabolism, the review focuses on the kidneys, liver, immune system, nervous system, cardiovascular and pulmonary systems, the search for biomarkers, and recent analyses of human cancer risk and incidence from TCE exposure.
The Incentive-Sensitization Theory of Addiction 30 Years On
Authors: Robinson Terry E. , Berridge Kent C.
Published: August 2024

The incentive-sensitization theory (IST) of addiction was first published in 1993, proposing that (a) brain mesolimbic dopamine systems mediate incentive motivation (“wanting”) for addictive drugs and other rewards, but not their hedonic impact (liking) when consumed; and (b) some individuals are vulnerable to drug-induced long-lasting sensitization of mesolimbic systems, which selectively amplifies their “wanting” for drugs without increasing their liking of the same drugs. Here we describe the origins of IST and evaluate its status 30 years on. We compare IST to other theories of addiction, including opponent-process theories, habit theories of addiction, and prefrontal cortical dysfunction theories of impaired impulse control. We also address critiques of IST that have been raised over the years, such as whether craving is important in addiction and whether addiction can ever be characterized as compulsive. Finally, we discuss several contemporary phenomena, including the potential role of incentive sensitization in behavioral addictions, the emergence of addiction-like dopamine dysregulation syndrome in medicated Parkinson's patients, the role of attentional capture and approach tendencies, and the role of uncertainty in incentive motivation.
Is the ≥1 cm Width of the Resection Margin in Benign and Borderline Phyllodes Tumor Necessary to Reduce Recurrence?
Authors: Changchit Nattakarn , Laokulrath Natthawadee , Rushatamukayanunt Pradit , Pisarnturakit Pongthep
Published: August 2024

Background. Phyllodes tumors (PTs) are fibroepithelial neoplasms of the breast, with current treatment guidelines recommending wide excision to achieve surgical margins of ≥1 cm to minimize the recurrence risk. However, diagnostic challenges with core biopsy specimens often result in suboptimal surgical margins. This study aims to elucidate the correlation between margin status and PT recurrence, thereby informing surgical decision‐making and enhancing patient outcomes. Methods. This single‐center, retrospective study reviewed records of Thai women diagnosed with PTs between 2011 and 2018, collecting data on demographics, clinical presentation, surgical approach, tumor grade, size, and margin status. The primary endpoint was recurrence. Results. Among 165 PT cases analyzed—49.1% borderline, 38.2% benign, and 12.7% malignant—the overall recurrence rate was 13.9% (n = 23) over a median follow‐up of 4.5 years. No significant difference in recurrence rates was observed between patients with negative resection margins <1 cm (ranging from <1 mm to 9 mm) compared to those with ≥1 cm (10.2% vs. 7.1%, p = 1.00). Notably, in negative resection margins <1 cm group, a margin <1 mm (close margin) was associated with a significantly higher recurrence rate compared to margins of 1–9 mm (17.0% vs. 4.9%, p = 0.04). Borderline PTs followed the overall trend, while benign PTs showed increased recurrence with positive margins. Multivariate analysis indicated a significant association between margins <1 mm and recurrence (adjusted HR = 10.78 (95% CI 1.32–88.07), p = 0.027), highlighting an increased recurrence risk with more extensive positive margins. Conclusion. Our findings suggest that a wide surgical margin of ≥1 centimeter may not be necessary to prevent recurrence in benign and borderline PTs. Notably, surgical margins narrower than 1 millimeter substantially elevate the recurrence likelihood in cases of borderline PTs. Furthermore, the presence of positive surgical margins correlates with an increased recurrence rate in benign PTs. These findings highlight the critical need for a strategic approach in determining surgical margins, tailored specifically to the type of PT, to enhance patient outcomes effectively.
Maternal Satisfaction and Associated Factors with Postcesarean Section Pain Management: A Cross‐Sectional Study
Authors: Admass Biruk Adie , Diress Fikadu Tadesse , Fentie Demeke Yilkal , Endalew Nigussie Simeneh
Published: August 2024

Background. Maternal satisfaction with pain management after cesarean delivery serves as an indicator of the quality of care. Assessing the level of satisfaction with postcesarean delivery pain management is paramount for both the mother and the healthcare institution. This study aimed to assess maternal satisfaction with postcesarean section pain management and associated factors at the Comprehensive Specialized Hospital in Northwest, Ethiopia, in 2023. Methods. An institution‐based cross‐sectional study was conducted from April to June 2023, involving 424 study participants. A consecutive sampling method was utilized for participant selection. Data were entered into Epidata and then exported to SPSS version 25 for analysis. Descriptive and analytic statistics were employed. Both bivariable and multivariable logistic regression analyses were conducted to identify factors associated with maternal satisfaction regarding postcesarean section pain management. Variables with a p value of <0.2 in the bivariable analysis were included in the multivariable analysis. In the multivariable analysis, variables with a p value of <0.05 were considered statistically significant. Crude odds ratio and adjusted odds ratio with 95% confidence intervals were calculated to demonstrate the strength of the association. Results. A total of 424 participants were included in the study with a response rate of 97.8%. The overall maternal satisfaction with postcesarean section pain management was 80.2% (95% CI: 76.1%–83.8%). Urban residence, elective cesarean section, mild pain, two and above previous history of cesarean section, and waiting less than 30 minutes to get analgesia were associated with maternal satisfaction with postcesarean section pain management. Conclusion. The overall maternal satisfaction with postcesarean section pain management was promising. Urban residence, elective cesarean section, previous history of cesarean section, mild pain, and waiting less than 30 minutes to get analgesia were predictor factors for maternal satisfaction with postcaesarian section pain management. We recommend that the stakeholders should give attention to enhancing maternal satisfaction.
Supplementary Figure S6 from Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression
Authors: Chakravarti Mohona , Bera Saurav , Dhar Sukanya , Sarkar Anirban , Choudhury Pritha Roy , Ganguly Nilanjan , Das Juhina , Sultana Jasmine , Guha Aishwarya , Biswas Souradeep , Das Tapasi , Hajra Subhadip , Banerjee Saptak , Baral Rathindranath , Bose Anamika
Published: August 2024

The file contains Supplementary Figure S6
Supplementary Figure S5 from Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression
Authors: Chakravarti Mohona , Bera Saurav , Dhar Sukanya , Sarkar Anirban , Choudhury Pritha Roy , Ganguly Nilanjan , Das Juhina , Sultana Jasmine , Guha Aishwarya , Biswas Souradeep , Das Tapasi , Hajra Subhadip , Banerjee Saptak , Baral Rathindranath , Bose Anamika
Published: August 2024

The file contains Supplementary Figure S5
Supplementary Fig. 3 from Long Noncoding RNA MSL3P1 Regulates CUL3 mRNA Cytoplasmic Transport and Stability and Promotes Lung Adenocarcinoma Metastasis
Authors: Shao Ming-Ming , Li Xin , Wei Rui-Qi , Chen Qing-Yu , Zhang Xin , Qiao Xin , Li Hui
Published: August 2024

MSL3P1 regulates the invasion through CUL3 in LUAD.
Supplementary Fig. 1 from Long Noncoding RNA MSL3P1 Regulates CUL3 mRNA Cytoplasmic Transport and Stability and Promotes Lung Adenocarcinoma Metastasis
Authors: Shao Ming-Ming , Li Xin , Wei Rui-Qi , Chen Qing-Yu , Zhang Xin , Qiao Xin , Li Hui
Published: August 2024

MSL3P1 is upregulated in a variety of cancers.
Supplementary Figure S2 from Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression
Authors: Chakravarti Mohona , Bera Saurav , Dhar Sukanya , Sarkar Anirban , Choudhury Pritha Roy , Ganguly Nilanjan , Das Juhina , Sultana Jasmine , Guha Aishwarya , Biswas Souradeep , Das Tapasi , Hajra Subhadip , Banerjee Saptak , Baral Rathindranath , Bose Anamika
Published: August 2024

The file contains Supplementary Figure S2
Supplementary Figure S8 from MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer
Authors: Plotnik Joshua P. , Zha Zheng , Feng Weiguo , Lee Irene , Riehm Jacob , McClure Ryan A. , Sandoval Stephanie , Uziel Tamar , Murphy Erin , Lu Xin , Lam Lloyd T.
Published: August 2024

Supplementary Figure S8
Supplementary Figure S7 from MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer
Authors: Plotnik Joshua P. , Zha Zheng , Feng Weiguo , Lee Irene , Riehm Jacob , McClure Ryan A. , Sandoval Stephanie , Uziel Tamar , Murphy Erin , Lu Xin , Lam Lloyd T.
Published: August 2024

Supplementary Figure S7
Supplementary Figure S3 from MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer
Authors: Plotnik Joshua P. , Zha Zheng , Feng Weiguo , Lee Irene , Riehm Jacob , McClure Ryan A. , Sandoval Stephanie , Uziel Tamar , Murphy Erin , Lu Xin , Lam Lloyd T.
Published: August 2024

Supplementary Figure S3
Table S7 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Metabolomics
Table S6 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

MicroRNA sequencing
Table S4 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Copy number changes
Table S2 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Targeted genes
Figure S3 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Supplementary Figure S3. (A) GSEA of mutational classes matched to transcriptional signatures in UTSW/Westmead tumors. (B) GSEA enrichment of “hallmark” gene sets in Wilms tumors with miRNA processing mutations.
Figure S1 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

(A) Landscape of mutations identified by whole exome sequencing. (B) Variants detected by WGS in Wilms tumors. A red “g” represents gain of chromosome 8p or 12p.
Supplementary Table 4 from Pediatric Chordoma: A Tale of Two Genomes
Authors: O’Halloran Katrina , Hakimjavadi Hesamedin , Bootwalla Moiz , Ostrow Dejerianne , Kerawala Rhea , Cotter Jennifer A. , Yellapantula Venkata , Kaneva Kristiyana , Wadhwani Nitin R. , Treece Amy , Foreman Nicholas K. , Alexandrescu Sanda , Velazquez Vega Jose , Biegel Jaclyn A. , Gai Xiaowu
Published: August 2024

List of rare ARID1B variants identified in the skull-base chordoma cohort.
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Authors: O’Halloran Katrina , Hakimjavadi Hesamedin , Bootwalla Moiz , Ostrow Dejerianne , Kerawala Rhea , Cotter Jennifer A. , Yellapantula Venkata , Kaneva Kristiyana , Wadhwani Nitin R. , Treece Amy , Foreman Nicholas K. , Alexandrescu Sanda , Velazquez Vega Jose , Biegel Jaclyn A. , Gai Xiaowu
Published: August 2024

Nucleic variants of the pediatric chodromas found in the COSMIC Cancer Census Genes
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Authors: O’Halloran Katrina , Hakimjavadi Hesamedin , Bootwalla Moiz , Ostrow Dejerianne , Kerawala Rhea , Cotter Jennifer A. , Yellapantula Venkata , Kaneva Kristiyana , Wadhwani Nitin R. , Treece Amy , Foreman Nicholas K. , Alexandrescu Sanda , Velazquez Vega Jose , Biegel Jaclyn A. , Gai Xiaowu
Published: August 2024

Rare nucleic variants of pediatric chordomas in COSMIC Cancer Census Genes
Supplementary figure 8 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

SLCO1B3 expression in PDX from lethal prostate cancer
Supplementary figure 3 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Cabazitaxel response
Supplementary figure 2 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Cabazitaxel dose response
Supplementary figure 15 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Gene expression analysis
Supplementary figure 14 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Densitometry
Supplementary figure 13 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Densitometry
Data from NSCLC Extracellular Vesicles Containing miR-374a-5p Promote Leptomeningeal Metastasis by Influencing Blood‒Brain Barrier Permeability
Authors: Jin Jie , Cui Yumeng , Niu Huicong , Lin Yanli , Wu Xiaojie , Qi Xuejiao , Bai Kaixuan , Zhang Yu , Wang Youliang , Bu Hui
Published: August 2024

Abstract
Leptomeningeal metastasis (LM) is a devastating complication of advanced non–small cell lung cancer (NSCLC). Its diagnosis and monitoring can be challenging. Recently, extracellular vesicle (EV) miRNAs have become a new noninvasive diagnostic biomarker. The purpose of this study was to examine the clinical value and role of EV miRNAs in NSCLC-LM. Next-generation sequencing analysis revealed that miRNAs with differential expression of EVs in sera of patients with NSCLC with LM and non-LM were detected to identify biological markers for the diagnosis of LM. Cellular and in vivo experiments were conducted to explore the pathogenesis of EV miRNA promoting LM in NSCLC. In the present study, we first demonstrated that the serum level of EV-associated miR-374a-5p in patients with LM of lung cancer was much higher than that in patients without LM and was correlated with the survival time of patients with LM. Further studies showed that EV miR-374a-5p efficiently destroys tight junctions and the integrity of the cerebral microvascular endothelial cell barrier, resulting in increased blood–brain barrier permeability. Mechanistically, miR-374a-5p regulates the distribution of ZO1 and occludin in endothelial cells by targeting γ-adducin, increasing vascular permeability and promoting LM.

Implications: These results suggest that serum NSCLC–derived EV miR-374a-5p is involved in premetastatic niche formation by regulating the permeability of the blood–brain barrier to promote NSCLC-LM and can be used as a blood biomarker for the diagnosis and prognosis of NSCLC-LM.
Data from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

Abstract
Understanding the mechanisms underlying resistance is critical to improving therapeutic outcomes in patients with metastatic castration–resistant prostate cancer. Previous work showed that dynamic interconversions between epithelial–mesenchymal transition to mesenchymal–epithelial transition defines the phenotypic landscape of prostate tumors, as a potential driver of the emergence of therapeutic resistance. In this study, we use in vitro and in vivo preclinical MDA PCa patient-derived xenograft models of resistant human prostate cancer to determine molecular mechanisms of cross-resistance between antiandrogen therapy and taxane chemotherapy, underlying the therapeutically resistant phenotype. Transcriptomic profiling revealed that resistant and sensitive prostate cancer C4-2B cells have a unique differential gene signature response to cabazitaxel. Gene pathway analysis showed that sensitive cells exhibit an increase in DNA damage, while resistant cells express genes associated with protein regulation in response to cabazitaxel. The patient-derived xenograft model specimens are from patients who have metastatic lethal castration–resistant prostate cancer, treated with androgen deprivation therapy, antiandrogens, and chemotherapy including second-line taxane chemotherapy, cabazitaxel. Immunohistochemistry revealed high expression of E-cadherin and low expression of vimentin resulting in redifferentiation toward an epithelial phenotype. Furthermore, the mitotic kinesin-related protein involved in microtubule binding and the SLCO1B3 transporter (implicated in cabazitaxel intracellular transport) are associated with resistance in these prostate tumors. Combinational targeting of kinesins (ispinesib) with cabazitaxel was more effective than single monotherapies in inducing cell death in resistant prostate tumors.

Implications: Our findings are of translational significance in identifying kinesin as a novel target of cross-resistance toward enhancing therapeutic vulnerability and improved clinical outcomes in patients with advanced prostate cancer.
Supplementary Table 9 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Prevalence of MET tyrosine kinase domain (TKD) mutations across tumor in “other cancers” from Supplementary Table 8.