bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacterial aetiology of non-resolving otitis media in South African children
Authors: Huebner Robin E. , Wasas Avril D. , Hockman Maurice , Klugman Keith P.
Published: March 2003

Little is known of the aetiology, serotypes or susceptibility of the pathogens causing non-resolving otitis media in children receiving care from specialists in private practice in developed or in developing countries. Increased access to antibiotics in the community amongst children receiving such private care in South Africa may be anticipated to lead to levels of resistance similar to those found in countries with similar models of private practice, such as the United States. This study was conducted to determine the aetiology of non-resolving otitis media in South African children receiving private care and to determine the antimicrobial resistance patterns and serotypes of the bacterial isolates.

Middle-ear fluid was cultured from 173 children aged two months to seven years with non-resolving acute otitis media accompanied by persistent pain or fever who were referred to otorhinolaryngologists for drainage of middle-ear fluid within 14 days of the start of symptoms. While 92 per cent of the children had recently received antibiotics and 54 per cent were currently receiving them, bacteria were isolated from 47 children (27 per cent). Streptococcus pneumoniae was the most common pathogen (35), followed by Haemophilus influenzae (nine), Staphylococcus aureus (six), Moraxella catarrhalis (two), Streptococcus pyogenes (two) and Pseudomonas aeruginosa (one). Two isolates were identified in each of eight children. Antimicrobial resistance to one or more antibiotics was found in 33/35 (94 per cent) of the pneumococci isolated, with resistance to penicillin in 86 per cent, resistance to trimethoprim-sulfamethoxazole in 54 per cent and to erythromycin and clindamycin in 69 per cent and 57 per cent, respectively. The pneumococcal serotypes found were 19F (28 per cent), 14 (26 per cent), 23F (23 per cent), 6B (nine per cent), 19A (87 per cent), and four (three per cent). Children with a bacterial pathogen isolated were younger (mean age of 17 months) than children from whom no bacteria were isolated (mean age of 23 months; p = 0.03). Isolation of a pneumococcus was also significantly associated with younger age (mean = 16 months versus 22 months, p = 0.03), the presence of fever (OR = 2.15, p = 0.049), and having one or more prior episodes of otitis media within the six months before tympanocentesis (OR = 7.72, p = 0.03). Almost all pneumococci isolated from non-resolving acute otitis media in this community are antibiotic-resistant and should be considered especially in young children who have failed previous therapy and who have non-resolving pain or fever.
Failure of antibiotic therapy in acute otitis media
Authors: Babin Emmanuel , Lemarchand Vincent , Moreau Sylvain , Goullet de Rugy Marc , Valdazo André , Bequignon Arnaud
Published: March 2003

The aim of this retrospective study was to determine the possible causes of failure of antibiotic therapy in children with acute otitis media (AOM). Thirty-nine samples of middle-ear fluid were obtained by myringotomy from 31 children suffering from AOM, unrelieved by antibiotic therapy administered for over 48 hours. The samples were analysed by the usual microbiological techniques, including cultures, tests for beta-lactamase producing strains and the determination of the minimal inhibitory concentration of penicillin for Streptococcus pneumoniae. In 14 samples, no bacterial strains were detected in the cultures of middle-ear fluid; and in two samples the cultures revealed two strains of bacteria. The bacteria most frequently identified were Haemophilus influenzae, found in 11 samples, and Streptococcus pneumoniae, found in seven samples, of which four produced strains with reduced susceptibility to penicillin. The failure of antibiotic therapy in AOM appears to be related to the increased resistance of Haemophilus influenzae and to the reduced susceptibility of Streptococcus pneumoniae to penicillin. Other factors contributing to the failure of antibiotic therapy in AOM may be the viruses or the bacteria that produce multiple pathogens in the middle ear.
Mastoiditis in children
Authors: Khan Ikramullah , Shahzad Farrukh
Published: March 2003

Fifty-two children with mastoiditis were treated at the Federal Government Services Hospital over a period of 15 years (from 1986 to 2000). The salient feature in these cases was the presence of a post-auricular swelling and mastoid abscess. Extensive cholesteatoma was seen in 80.7 per cent of cases and 19.3 per cent had granulations in the mastoid cavity. Significantly, all patients had a history of chronic ear discharge prior to abscess formation. These children belonged to poor communities, were malnourished and attended hospital in a state of emergency.

The presentation and course of the disease confirms the aggressive and potentially serious nature of the pathology requiring early medical attention in order to avert impending complications. It appears that in our environment acute mastoiditis with abscess formation develops from chronic otitis media and the cholesteatoma. The surgical procedures conducted in these cases were radical and modified radical mastoidectomy.
The Canterbury technique for canalplasty via an endaural approach in the surgical management of chronic refractory otitis externa
Authors: Sharp H. R. , Oakley R. J. , Padgham N. D.
Published: March 2003

We describe an endaural technique for soft tissue and bony meatoplasty and canalplasty in the surgical management of chronic otitis externa unresponsive to medical treatment and out-patient microsuction. Following analysis of the surgical outcome via a retrospective review of patient records, we would recommend this surgical treatment in this patient group.
Incomplete tracheal duplication associated with severe unilateral lung hypoplasia
Authors: Haben C. Michael , Nguyen Van-Hung , Russell Laura , Berry Margaret A. , Manoukian John J.
Published: March 2003

A rare case of incomplete tracheal duplication with severe unilateral lung hypoplasia is presented. Photo-documentation of the gross post-mortem specimens is presented so that the anatomical aspects of this unusual anomaly can be recognized and appreciated. Clinical information is presented in the hope that successful premorbid identification of potential complications of this anomaly could be made by future physicians. To our knowledge, this is the first reported case of pathologically-confirmed duplication of the trachea.
Resection of a large benign pharyngo-oesophageal submucous mesenchymoma via laterocervical approach
Authors: Liu Lisi , Hu Shaoxian , Zhen Hongtao , Tao Yanling , Tang Yingxiong , Huang Melissa
Published: March 2003

Two rare cases of benign submucosal pharyngo-oesophageal mesenchymoma are presented in this paper. One patient was treated by tumour removal via a combined thoracic and laterocervical approach and the other by resection through a laterocervical approach. The paper discusses the pathology and diagnosis of benign mesenchymomas. The authors suggest that for large tumours located in the pharynx and extending down the oesophagus without adhesion to the oesophageal wall, the laterocervical approach can avoid complications associated with the thoracic approach. The new technique caused less tissue damage and provided a quicker recovery and shorter hospitalization.
Internal jugular vein thrombosis following ovarian hyperstimulation
Authors: Jesudason W. V. , Small M.
Published: March 2003

Superovulation therapy with in vitro fertilization (IVF) treatment may result in ovarian hyperstimulation syndrome and a hypercoaguable state. The site of thrombus formation is commonly in the upper venous extremities. One case of bilateral internal jugular vein thrombosis following ovarian hyperstimulation is described. The clinical presentation, investigations and management are discussed.
RBP16 is a multifunctional gene regulatory protein involved in editing and stabilization of specific mitochondrial mRNAs in Trypanosoma brucei
Authors: PELLETIER MICHEL , READ LAURIE K.
Published: March 2003

RBP16 is a Trypanosoma brucei mitochondrial RNA-binding protein that associates with guide RNAs (gRNAs), mRNAs, and ribosomal RNAs. Based on its inclusion in the multifunctional Y-box protein family and its ability to bind multiple RNA classes, we hypothesized that RBP16 plays a role in diverse aspects of mitochondrial gene regulation. To gain insight into RBP16 function, we generated cells expressing less than 10% of wild-type RBP16 levels by tetracycline-regulated RNA interference (RNAi). Poisoned primer extension analyses revealed that edited, but not unedited, CYb mRNA is reduced by ∼98% in tetracycline-induced RBP16 RNAi cells, suggesting that RBP16 is critical for CYb RNA editing. The down-regulation of CYb editing in RBP16 RNAi transfectants apparently entails a defect in gRNA utilization, as gCYb[560] abundance is similar in uninduced and induced cells. We observed a surprising degree of specificity regarding the ability of RBP16 to modulate editing, as editing of mRNAs other than CYb is not significantly affected upon RBP16 disruption. However, the abundance of the never edited mitochondrial RNAs COI and ND4 is reduced by 70%–80% in RBP16 RNAi transfectants, indicating an additional role for RBP16 in the stabilization of these mRNAs. Analysis of RNAs bound to RBP16 immunoprecipitated from wild-type cells reveals that RBP16 is associated with multiple gRNA sequence classes in vivo, including those whose abundance and usage appear unaffected by RBP16 disruption. Overall, our results indicate that RBP16 is an accessory factor that regulates the editing and stability of specific populations of mitochondrial mRNAs.
RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis
Authors: OGURO AKIHIRO , OHTSU TAKASHI , SVITKIN YURI V. , SONENBERG NAHUM , NAKAMURA YOSHIKAZU
Published: March 2003

The mammalian translation initiation factor 4A (eIF4A) is a prototype member of the DEAD-box RNA helicase family that couples ATPase activity to RNA binding and unwinding. In the crystal form, eIF4A has a distended ‘‘dumbbell’’ structure consisting of two domains, which probably undergo a conformational change, on binding ATP, to form a compact, functional structure via the juxtaposition of the two domains. Moreover, additional conformational changes between two domains may be involved in the ATPase and helicase activity of eIF4A. The molecular basis of these conformational changes, however, is not understood. Here, we generated RNA aptamers with high affinity for eIF4A by in vitro RNA selection-amplification. On binding, the RNAs inhibit ATP hydrolysis. One class of RNAs contains members that exhibit dissociation constant of 27 nM for eIF4A and severely inhibit cap-dependent in vitro translation. The binding affinity was increased on Arg substitution in the conserved motif Ia of eIF4A, which probably improves a predicted arginine network to bind RNA substrates. Selected RNAs, however, failed to bind either domain of eIF4A that had been split at the linker site. These findings suggest that the selected RNAs interact cooperatively with both domains of eIF4A, either in the dumbbell or the compact form, and entrap it into a dead-end conformation, probably by blocking the conformational change of eIF4A. The selected RNAs, therefore, represent a new class of specific inhibitors that are suitable for the analysis of eukaryotic initiation, and which pose a potential therapeutic against malignancies that are caused by aberrant translational control.
Antagonistic signals within the COX2 mRNA coding sequence control its translation in Saccharomyces cerevisiae mitochondria
Authors: WILLIAMS ELIZABETH H. , FOX THOMAS D.
Published: March 2003

Translation of the mitochondrially coded COX2 mRNA within the organelle in yeast produces the precursor of Cox2p (pre-Cox2p), which is processed and assembled into cytochrome c oxidase. The mRNA sequence of the first 14 COX2 codons, specifying the pre-Cox2p leader peptide, was previously shown to contain a positively acting element required for translation of a mitochondrial reporter gene, ARG8m, fused to the 91st codon of COX2. Here we show that three relatively short sequences within the COX2 mRNA coding sequence, or structures they form in vivo, inhibit translation of the reporter in the absence of the positive element. One negative element was localized within codons 15 to 25 and shown to function at the level of the mRNA sequence, whereas two others are within predicted stem-loop structures formed by codons 22–44 and by codons 46–74. All three of these inhibitory elements are antagonized in a sequence-specific manner by reintroduction of the upstream positive-acting sequence. These interactions appear to be independent of 5′- and 3′-untranslated leader sequences, as they are also observed when the same reporter constructs are expressed from the COX3 locus. Overexpression of MRS2, which encodes a mitochondrial magnesium carrier, partially suppresses translational inhibition by each isolated negatively acting element, but does not suppress them in combination. We hypothesize that interplay among these signals during translation in vivo may ensure proper timing of pre-Cox2p synthesis and assembly into cytochrome c oxidase.
Antagonistic regulation of α-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein
Authors: GROMAK NATALIA , MATLIN ARIANNE J. , COOPER THOMAS A. , SMITH CHRISTOPHER W.J.
Published: March 2003

The α-actinin gene has a pair of alternatively spliced exons. The smooth muscle (SM) exon is repressed in most cell types by polypyrimidine tract binding protein (PTB). CELF (CUG-BP and ETR3-like factors) family proteins, splicing regulators whose activities are altered in myotonic dystrophy, were found to coordinately regulate selection of the two α-actinin exons. CUG-BP and ETR3 activated the SM exon, and along with CELF4 they were also able to repress splicing of the NM (nonmuscle) exon both in vivo and in vitro. Activation of SM exon splicing was associated with displacement of PTB from the polypyrimidine tract by binding of CUG-BP at adjacent sites. Our data provides direct evidence for the activity of CELF proteins as both activators and repressors of splicing within a single-model system of alternative splicing, and suggests a model whereby α-actinin alternative splicing is regulated by synergistic and antagonistic interactions between members of the CELF and PTB families.
Lentivirus-delivered stable gene silencing by RNAi in primary cells
Authors: STEWART SHEILA A. , DYKXHOORN DEREK M. , PALLISER DEBORAH , MIZUNO HANA , YU EVAN Y. , AN DONG SUNG , SABATINI DAVID M. , CHEN IRVIN S.Y. , HAHN WILLIAM C. , SHARP PHILLIP A. , WEINBERG ROBERT A. , NOVINA CARL D.
Published: March 2003

Genome-wide genetic approaches have proven useful for examining pathways of biological significance in model organisms such as Saccharomyces cerevisiae, Drosophila melanogastor, and Caenorhabditis elegans, but similar techniques have proven difficult to apply to mammalian systems. Although manipulation of the murine genome has led to identification of genes and their function, this approach is laborious, expensive, and often leads to lethal phenotypes. RNA interference (RNAi) is an evolutionarily conserved process of gene silencing that has become a powerful tool for investigating gene function by reverse genetics. Here we describe the delivery of cassettes expressing hairpin RNA targeting green fluorescent protein (GFP) using Moloney leukemia virus-based and lentivirus-based retroviral vectors. Both transformed cell lines and primary dendritic cells, normally refractory to transfection-based gene transfer, demonstrated stable silencing of targeted genes, including the tumor suppressor gene TP53 in normal human fibroblasts. This report demonstrates that both Moloney leukemia virus and lentivirus vector-mediated expression of RNAi can achieve effective, stable gene silencing in diverse biological systems and will assist in elucidating gene functions in numerous cell types including primary cells.
Identification of novel components ofTrypanosoma bruceieditosomes
Authors: PANIGRAHI ASWINI K. , SCHNAUFER ACHIM , ERNST NANCY L. , WANG BINGBING , CARMEAN NICOLE , SALAVATI REZA , STUART KENNETH
Published: March 2003

The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins inTrypanosoma brucei. They were identified by mass spectrometric analysis of functional editosomes that were purified by serial ion exchange/gel permeation chromatography, immunoaffinity chromatography specific to the TbMP63 editosome protein, or tandem affinity purification based on a tagged RNA editing ligase. The newly identified proteins have ribonuclease and/or RNA binding motifs suggesting nuclease function for at least some of these. Five of the proteins are interrelated, as are two others, and one is related to four previously identified editosome proteins. The implications of these findings are discussed.
Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA
Authors: SILVERMAN SCOTT K.
Published: March 2003

Switches and sensors play important roles in our everyday lives. The chemical properties of RNA make it amenable for use as a switch or sensor, both artificially and in nature. This review focuses on recent advances in artificial RNA switches and sensors. Researchers have been applying classical biochemical principles such as allostery in elegant ways that are influencing the development of biosensors and other applications. Particular attention is given here to allosteric ribozymes (aptazymes) that are regulated by small organic molecules, by proteins, or by oligonucleotides. Also discussed are ribozymes whose activities are controlled by various nonallosteric strategies.
Effects of orthographic transparency on reading and phoneme awareness in children learning to read in Wales
Authors: Spencer Llinos H. , Hanley J. Richard
Published: March 2003

The relationship between the development of reading skills and the consistency of the orthography (writing system) is investigated in a study that examines reading acquisition in children living in Wales. Performance of children learning to read Welsh (a transparent alphabetic orthography) on tests of reading and phoneme detection was compared with the performance of children learning to read English (an opaque alphabetic orthography). The children were tested during their second year of formal reading instruction at school when they were aged between 5 and 6 years, and again one year later. The children learning to read in Welsh performed significantly better at reading both real words and nonwords than children learning to read in English. The English readers made fewer phonologically based reading errors. The Welsh readers also performed better on a phoneme awareness task. These findings support the claim that children learn to read more quickly in a transparent orthography, and provide further evidence that the consistency of the orthography influences the initial adoption of different strategies for word recognition.
Mental imagery and creativity: A meta‐analytic review study
Authors: LeBoutillier Nicholas , Marks David F.
Published: March 2003

The reports of many creative individuals suggest the use of mental imagery in scientific and artistic production. A variety of protocols have tested the association between mental imagery and creativity, but the individual differences approach has been most frequently employed. This approach is assessed here through a range of meta‐analytic tests. Database searches revealed 18 papers employing the individual differences approach that were subjected to a conservative set of selection criteria. Nine studies (1,494 participants) were included in the final analyses. A marginal, but statistically significant, Fisher's Z‐transformed correlation coefficient was revealed. Further analyses showed little difference between form and type of self‐reported imagery and divergent thinking. Explanations for the failure to account for more than 3% of the variance in the data sets are discussed in the context of anecdotal reports, task validity, and design problems.
The effects of orientation on detection and identification of facial expressions of emotion
Authors: Prkachin Glenda C.
Published: March 2003

Signal detection procedures were used to examine the ability of participants to detect and label facial expressions of emotion in an upright or inverted orientation when the faces were rapid videotaped presentations. The detection and identification of facial expressions were remarkably accurate. In the upright orientation, the A′ measure of sensitivity was above .9 for detection and identification of all six facial expressions of emotion. Sensitivity to inverted expressions was diminished for all emotions; however, the extent of the decline in sensitivity depended upon the specific facial expression. If the expression was difficult to detect or label in the upright orientation, the sensitivity score was lower in the inverted orientation. An assessment of the errors made in the detection and labelling process allowed a demonstration of the specific facial expressions that were confused in either the upright or inverted orientation. The assessment of sensitivity and analysis of the errors suggests that the nature of perceptual processing of some, but not all, facial expressions is changed by inversion.
Do clever brains age more slowly? Further exploration of a nun result
Authors: Rabbitt Patrick , Chetwynd Amanda , McInnes Lynn
Published: March 2003

Recent epidemiological evidence suggests that individuals who have higher levels of mental ability in youth experience a slower cognitive decline as they grow old. In a sample of 3,263 Newcastle residents, average scores on a vocabulary test (Raven's 1965 ‘Mill Hill A') did not vary, while average scores on a test of fluid mental ability (the Heim, 1970, AH 4 (1) group intelligence test) sharply declined with age from 49 to 92 years. In young adults, Mill Hill A scores are good proxies for AH 4 (1) scores. This relationship allowed individuals' youthful AH 4 (1) test scores to be estimated from their current, unchanged, Mill Hill A scores so that age‐related changes in AH 4 test scores over the adult life‐span could be estimated and compared between high and low ability groups, men and women, and individuals of different levels of socio‐economic advantage. The cross‐sectional estimated rate of age‐related decline in general mental ability was found to be the same for people of all levels of ability and socio‐economic advantage, and not to differ between men and women.
The effect of item feedback on multiple‐choice test responses
Authors: Delgado Ana R. , Prieto Gerardo
Published: March 2003

This study examines the effects of item feedback on multiple‐choice test responses. In the first experiment, a positive effect was predicted under instructions advising a penalty for errors; a larger beneficial effect on female scores was expected, given the (presumed) tendency of female participants toward omission when uncertain. Feedback effects were either negligible or negative, and the expected interaction effect with gender was not found. The second experiment was a high‐powered replication of the feedback effect on errors, controlling for participants' ability. The discussion takes into account other evidence to state that recommendations of providing item feedback in the context of testing are neither theoretically nor empirically founded.
‘There's no smoke without fire’: Are male ex‐partners perceived as more ‘entitled’ to stalk than acquaintance or stranger stalkers?
Authors: Sheridan Lorraine , Gillett Raphael , Davies Graham M. , Blaauw Eric , Patel Darshana
Published: March 2003

In a stalking scenario, the prior relationship between and the gender of stalker and victim were systematically manipulated in order to judge culpability and consequences for the persons involved. Written vignettes were presented to 168 participants who responded via seven Likert scales. Stalker‐victim relationship had three levels: ex‐partner, acquaintance and stranger. In accordance with the ‘Just World’ hypothesis (Lerner, 1980), the victim was judged as having greater responsibility for the stalking when their harasser was an ex‐partner or a prior acquaintance rather than a stranger, and police intervention was felt to be most necessary when the stalker was a stranger. Sex of stalker and victim was manipulated, and the following comparisons proved significant: when the perpetrator was male, bodily injury to the victim was seen as more likely and police intervention as more necessary than when the perpetrator was female; and male victims were viewed as more responsible for the scenario and as possessing greater powers to alleviate it. The Just World hypothesis and gender stereotypes provide a plausible account for these findings. Future research should determine whether criminal convictions show similar biases towards convicting male and stranger stalkers more often than female and ex‐partner stalkers.
Effort after meaning and the hedonic value of paintings
Authors: Russell Phil A.
Published: March 2003

Two experiments tested the prediction that providing the viewer with information about abstract and semi‐abstract paintings, in the form of titles and descriptions, would increase the paintings' perceived meaningfulness and hedonic value. The meaningfulness prediction was supported in both experiments. The results of one experiment, using a between‐participants design, failed to support the hedonic value prediction, but the results of the other, using a within‐participants design, supported the prediction. Failure to find an effect of information on hedonic value in other experiments may result from the use of between‐participants designs that are relatively insensitive to the effects of different evaluative conditions. The results are discussed in the light of the ‘effort after meaning’ theory that part of the pleasure derived from looking at a painting stems from making a successful interpretation of it and picking up the artist's message.
Phenomenal characteristics of autobiographical memories for positive, negative, and neutral events
Authors: D'Argembeau Arnaud , Comblain Christine , Van der Linden Martial
Published: March 2003

We investigated memory qualities for positive, negative, and neutral autobiographical events. Participants recalled two personal experiences of each type and then rated their memories on several characteristics (e.g. sensorial and contextual details). They also reported whether they ‘see’ the events in their memories from their own perspective (‘field’ memories) or whether they ‘see’ the self engaged in the event as an observer would (‘observer’ memories). Positive memories contained more sensorial (visual, smell, taste) and contextual (location, time) details than both negative and neutral events, whereas negative and neutral memories did not differ on most dimensions. Positive and negative events were more often recollected with a field perspective than neutral events. Finally, participants were classified in four groups according to the repressive coping style framework. Emotional memories of repressors were not less detailed than those of the other groups. Copyright © 2002 John Wiley & Sons, Ltd.
Expert memory: the interaction of stimulus structure, attention, and expertise
Authors: Weber Nathan , Brewer Neil
Published: March 2003

This experiment focuses on the three‐way interaction between domain‐relevant structure, attention to domain‐relevant structure, and expertise in their effect on recall for field‐hockey information. It was predicted that experts' recall would decrease with the amount of domain‐relevant structure, but only when they were able to attend to the structure within the stimuli. Novices' recall was not predicted to vary with these factors. The study used a 3 × 2 × 2 mixed‐design with one between‐subjects factor, field hockey expertise (expert and novice), and two within‐subjects factors, domain‐relevant structure (high, moderate and low) and attention to structure (attending and non‐attending). Twenty‐four experts and 24 novices each listened to six audio‐taped scenarios (1 in each of the 6 structure × attention conditions) describing a sequence of field hockey play and recall was tested. The results demonstrated significant main effects for expertise, structure, and attention, and interactions of (a) structure and expertise, and (b) structure and attention. Importantly, the significant structure, attention, and expertise interaction provided the first direct empirical support for the constraint attunement hypothesis (Vicente and Wang, 1998) and for that aspect of the template theory (Gobet and Simon, 1996a,b). Copyright © 2002 John Wiley & Sons, Ltd.
Eliciting and comparing false and recovered memories: an experimental approach
Authors: Smith Steven M. , Gleaves David H. , Pierce Benton H. , Williams Tara L. , Gilliland Todd R. , Gerkens David R.
Published: March 2003

We describe an experimental paradigm designed to elicit both recovered and false memories in the laboratory. All participants saw, on a video screen, three critical categorized lists of words mixed in randomly with eighteen filler categorized lists. Those in the blocking condition then had several paper‐and‐pencil tasks that involved only the 18 non‐critical filler lists. An uncued recall test was then given, asking participants to recall all the lists they originally saw on the video screen. Finally, there was a cued recall test that provided category cues for the three critical lists. Substantial memory blocking of critical lists on the uncued test and recovery on the cued recall test was observed in all three experiments. In Experiments 2 and 3, many false and recovered memories were elicited on the cued recall test by including cues for the three critical (forgotten) lists, plus cues for three lists that had never been presented. False memories were distinguishable from truly recovered memories in cued recall by ‘know’ versus ‘remember’ judgements, and by confidence ratings; accurately recovered memories were associated with higher confidence. False and recovered memories could not be discriminated based on recall latency. The results repeatedly show powerful effects of memory blocking and recovery. We also show that recovered and false memories can be elicited within a single experimental procedure, and there may be unique characteristics of each. Although we urge caution in generalizing to false and recovered memories of trauma, we suggest that variations of our comparative memory paradigm may be useful for learning about such phenomena. Copyright © 2003 John Wiley & Sons, Ltd.
Presentation modality effects in studying passages. Are mental images always effective?
Authors: De Beni Rossana , Moè Angelica
Published: March 2003

The present research has tested the different efficacy of imagery‐based and verbally‐based strategies in the study of three passages presented orally or in written form. The first passage was a description rich in easily imagined details. The second was an abstract passage, easy to verbalize, but not to imagine. The third was the spatial description of a pathway which could be both imagined and verbalized. Experiment 1 compared participants who were instructed in the use of Imagery or verbal Rehearsal while in Experiment 2 participants had high or low imagery ability. A facilitating effect of oral presentation for Imagery and high‐imagery ability groups and of written presentation for Rehearsal and low imagery‐ability groups were hypothesized. Data confirmed this facilitating effect and showed that it was more evident for the easier‐to‐imagine passages. Results are discussed in a selective interference and working memory framework. Future implications and practical suggestions are given. Copyright © 2003 John Wiley & Sons, Ltd.
Adapting communicative strategies to computer‐mediated communication: an analysis of task performance and dialogue structure
Authors: Newlands Alison , Anderson Anne H. , Mullin Jim
Published: March 2003

This study investigates how people adapt to text‐based computer‐mediated communication (CMC), specifically focusing on how novice users change their communicative strategies over time to achieve effective communication. Twenty pairs of university students completed three collaborative problem‐solving tasks (The Map Task; Brown et al., 1984), over a series of days. Their performance was compared with the results from spoken interactions, taken from the Human Communications Research Centre corpus of Map Task dialogues. Task performance by CMC participants was initially poorer when compared to the performance of spoken interlocutors, but improved as they gained experience of the CMC context. Detailed analysis of the process of communication, using dialogue measures and Conversational Games Analysis (Kowtko et al., 1992), shows that effective communication and collaboration was achieved by users of the CMC system after a relatively moderate amount of experience. Participants in the CMC context changed the way in which they gave instructions and interacted over time. They adopted a precise, highly specified style of giving directions which required little interpretation by addressees. This concise style of communication is rarely found in face‐to‐face or spoken interactions. Copyright © 2003 John Wiley & Sons, Ltd.
Effects of feedback on the overestimated capacity to detect lies and the underestimated ability to tell lies
Authors: Elaad Eitan
Published: March 2003

People tend to overestimate their capacity to detect lying in others and to underestimate their own ability to tell lies. These biases were demonstrated in a sample of 60 police officers. In a lie‐detection task, the officers evaluated their accuracy as high and were overconfident in their judgements. In fact, their performance was below chance level. Participants also received false feedback about their performance. When the feedback suggested that they had performed better than they thought, this further enhanced their perceived lie‐detection capacity and also increased their belief in their ability to conceal their own lies. When the feedback suggested they had performed worse than they thought, their ratings of both lie detection and their lie‐telling abilities were lowered. Results are discussed in terms of anchoring, availability, and the self‐assessment bias. On a practical level, the tendency of police interrogators to overestimate their ability to detect deception could change suspicion into certainty and increase the risk of a false confession. Copyright © 2003 John Wiley & Sons, Ltd.
Inter‐racial contact and the own‐race bias for face recognition in South Africa and England
Authors: Wright Daniel B. , Boyd Catherine E. , Tredoux Colin G.
Published: March 2003

Own‐race bias, where people are more accurate recognizing faces of people from their own race than other races, can lead to misidentification and, in some cases, innocent people being convicted. This bias was explored in South Africa and England, using Black and White participants. People were shown several photographs of Black and White faces and were later asked if they had seen these faces (and several fillers). In addition, participants were given a questionnaire about inter‐racial contact. Cross‐race identification accuracy for Black participants was positively correlated with self‐reported inter‐racial contact. The confidence–accuracy relationship was strongest when making own‐race judgements. Copyright © 2003 John Wiley & Sons, Ltd.
Cytogenetic and molecular characterization of a de novo 4q24qter duplication and correlation to the associated phenotype
Authors: Rinaldi R. , De Bernardo C. , Assumma M. , Grammatico B. , Buffone E. , Poscente M. , Grammatico P.
Published: March 2003

We report on a newborn with severe psychomotor retardation, minor anomalies, congenital heart defects, thumb and urogenital abnormalities. Cytogenetic analysis showed a 4q24qter duplication, never described before, as the result of a de novo t(4;14). The extension of the duplicated 4q region was defined by FISH using YAC probes. The breakpoint was localized between 106.3cM (YAC 800f2, D4S1572) and 111 cM (YAC 744e4, D4S1564). Comparing our patient with those previously reported in literature, we observed some features mature frequently reported in these patients: psychomotor retardation, retromicrognathia, low set and/or malformed ears and some more specific traits: congenital cardiac defects, hypoplastic thumb and urogenital abnormalities. © 2003 Wiley‐Liss, Inc.
Geophysical investigation for mapping the archaeological features at Qantir, Sharqyia, Egypt
Authors: Abdallatif T. F. , Mousa S. E. , ElBassiony A.
Published: March 2003

Two geophysical methods were used for mapping the archaeological features at Qantir village: magnetic and resistivity surveys. The magnetic survey was carried out before the resistivity survey in order to evaluate the distribution of hidden archaeological features and cultural relics. It was conducted over an area of 120 × 100 m using a fluxgate gradiometer (Geoscan FM36) that measures the vertical gradient of the geomagnetic field. The readings were logged every 0.5 m along 20 m, zigzag traverses. The resultant data were processed and treated to produce a high‐quality magnetic image. The final magnetogram and graphical interpretation plot show the distribution of high and low magnetic features that reflect the buried archaeological and non‐archaeological features. Subsequently, a resistivity survey was carried out over interesting areas identified from the initial results of the magnetogram. Four Wenner profiles were also measured, named P1W, P2W, P3W and P4W. The minimum electrode spacing used through all the profiles was 1 m and the maximum electrode spacing varied from one profile to another according to its length. These data were used to construct four apparent resistivity pseudosections. A comparison between the magnetic vertical gradient profile and resistivity inverse models was performed in order to check the value of using the Wenner configuration in parallel with the gradiometer survey. The geophysical investigation mapped some archaeological features with a high probability of indicating the presence of storage and burial chambers, bisecting walls, ditches and streets. Copyright © 2003 John Wiley & Sons, Ltd.
Archaeogeophysical study on the site of Tell Toukh El‐Qaramous, Sharkia Governorate, East Nile Delta, Egypt
Authors: Ghazala H. , El‐Mahmoudi A. S. , Abdallatif T. F.
Published: March 2003

The archaeological site of Tell Toukh El‐Qaramous, which is located to the south of Abu Kebir, Sharkiya Governorate, was subjected to detailed geophysical studies using magnetic vertical gradient and geoelectric resistivity survey. The success of these surveys depends on the contrast in the physical properties between the dominant sedimentary deposits (clays and sands) and the buried archeological constructions. The area of study occupies about 80 acres at present. It was subjected firstly to a regional geophysical survey to discover the subsurface conditions above one of the most important military fortress that had been constructed to be vanguard of the eastern entry to Egypt during the Ptolemaic age (323–30 BC).

Detailed gridded magnetic (0.5 m grid interval) and geoelectric resistivity surveys (2 m grid interval) were also carried out at a selected site of about 50 × 100 m according to the recommendations of the archaeologists who periodically carried out excavation of the archaeological remains. Such surveys could help mapping of the anomalous features that probably reflect the buried archaeological remains.

The integrated results of the magnetic gradient images obtained as well as apparent resistivity maps for depths ranges from 1 to 5 m gave fascinating results. The results indicate that the Tell‐Toukh El‐Qaramous has been built on a buried sand gezira. Also, groups of ancients walls made of mud bricks and some interesting locations of archeological buried artefacts have been delineated. Both the magnetic and resistivity data supported each other and are in good agreement for the same locations of archeological interest. Copyright © 2002 John Wiley & Sons, Ltd.
The study and characterization of Emperor Traiano's Villa (Altopiani di Arcinazzo, Roma) using high‐resolution integrated geophysical surveys
Authors: Piro S. , Goodman D. , Nishimura Y.
Published: March 2003

In this work, the results of high‐resolution integrated geophysical surveys of the archaeological site of Traiano's Villa (Altopiani di Arcinazzo, Roma, Italy) are presented. The Villa of Roman Emperor Marco Ulpio Traino (AD 98–117) was built in Arcinazzo (Italy), approximately 55 km northeast of Rome. Today, the only remains left standing at the site are the public building entrances comprising a small portion of the entire site. Over 5 ha, adjacent to the entrance remains, had not been surveyed. As part of an ongoing study to rescue this national archaeological treasure, high‐resolution ground‐penetrating radar (GPR) surveys, using a submetre profile spacing, integrated with a gradiometric survey, were conducted. Amplitude GPR time‐slice analysis indicates that many structural foundations and walls of the villa are still well preserved below the surface. Time‐slices below 1.5 m in one area indicate two large mushroom shaped structures enclosed within a large building over 100 m in length. These structures are believed to be dipping pools within a larger structure believed to be the bathhouse to the villa. At the location west of the bathhouse a large oval shaped anomaly 45 m along its major axis was located. This subsurface structure is believed to be an oval garden pond or a swimming pool. Several other remnants of rectangular buildings coincident with the oval structure but much deeper were also imaged. Other structures include a long rectangular corridor that contains many square shaped rooms, which has been interpreted as a criptoporticus.

The magnetic map, related to part of the area investigated, shows many dipole anomalies. These anomalies represent linear and semicircular structures of the villa. The magnetic results provide complementary information to the GPR survey that lines out walls and floors. Copyright © 2003 John Wiley & Sons, Ltd.
GPR survey to understand the stratigraphy of the Roman Ships archaeological site (Pisa, Italy)
Authors: Carrozzo M. T. , Leucci G. , Negri S. , Nuzzo L.
Published: March 2003

Two surveys with ground‐penetrating radar (GPR) were carried out in June and December 2000 at the Roman Ships archaeological site (Pisa, Italy). Both surveys were undertaken at selected locations, placed on the plan of excavation (−5 m from the ground surface), using a GSSI Sir System2 incorporating 35, 100, 200 and 500 MHz centre‐frequency antennae. The main purpose of the two surveys was to test the value of radar in respect of penetration depth and, therefore, to reconstruct the geological stratigraphy, given the general not too favourable site conditions. The results showed that most of the GPR data acquired with the 35 MHz antenna were contaminated by strong reflections caused by above‐ground objects near the survey lines. In fact, the archaeological area is protected on every side by iron barriers, around 6 m high, in order to guarantee the stability of the walls and to contain the present shallow groundwater. Therefore, it is very important to recognize the reflections through air (surface scattering) and not to confuse them with the reflections from underground geological features. For this purpose higher frequency antennae, less prone to surface scattering problems, although allowing shallower penetration depths, also have been used. Their higher resolution permitted the identification of some anomalies probably related to shallow stratigraphical boundaries, as well as other anomalies probably attributable to archaeological features. Moreover, the numerous measurements carried out in the second survey to estimate the velocity of propagation of the electromagnetic waves in the ground, contributed to a better interpretation of the geology of the site. Copyright © 2003 John Wiley & Sons, Ltd.
Three target document range metrics for university web sites
Authors: Thelwall Mike , Wilkinson David
Published: March 2003

Three new metrics are introduced that measure the range of use of a university Web site by its peers through different heuristics for counting links targeted at its pages. All three give results that correlate significantly with the research productivity of the target institution. The directory range model, which is based upon summing the number of distinct directories targeted by each other university, produces the most promising results of any link metric yet. Based upon an analysis of changes between models, it is suggested that range models measure essentially the same quantity as their predecessors but are less susceptible to spurious causes of multiple links and are therefore more robust.
Information as commodity and economic sector: Its emergence in the discourse of industrial classification
Authors: Malone Cheryl Knott , Elichirigoity Fernando
Published: March 2003

In a critical analysis of the recent development and deployment of the North American Industry Classification System, this article focuses on the discourse surrounding the creation of the system's “information” category. A close reading of the relevant government documents suggests that the category functions simultaneously to position information as a major sector of the economy and to organize data about information as a commodity. The discourse also points to the continuing complexities involved in conceptualizing information as a measurable object.
Modeling the information‐seeking behavior of social scientists: Ellis's study revisited
Authors: Meho Lokman I. , Tibbo Helen R.
Published: March 2003

This paper revises David Ellis's information‐seeking behavior model of social scientists, which includes six generic features: starting, chaining, browsing, differentiating, monitoring, and extracting. The paper uses social science faculty researching stateless nations as the study population. The description and analysis of the information‐seeking behavior of this group of scholars is based on data collected through structured and semi‐structured electronic mail interviews. Sixty faculty members from 14 different countries were interviewed by e‐mail. For reality check purposes, face‐to‐face interviews with five faculty members were also conducted. Although the study confirmed Ellis's model, it found that a fuller description of the information‐seeking process of social scientists studying stateless nations should include four additional features besides those identified by Ellis. These new features are: accessing, networking, verifying, and information managing. In view of that, the study develops a new model, which, unlike Ellis's, groups all the features into four interrelated stages: searching, accessing, processing, and ending. This new model is fully described and its implications on research and practice are discussed. How and why scholars studied here are different than other academic social scientists is also discussed.