bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Utility of 18F-FDG PET in Neuroendocrine Tumors Prior to Peptide Receptor Radionuclide Therapy: A Systematic Review and Meta-Analysis
Authors: Alevroudis Emmanouil , Spei Maria-Eleni , Chatziioannou Sofia N. , Tsoli Marina , Wallin Göran , Kaltsas Gregory , Daskalakis Kosmas
Published: April 2021

The role of 18F-FDG PET in patients with variable grades of neuroendocrine tumors (NETs) prior to peptide receptor radionuclide therapy (PRRT) has not been adequately elucidated. We aimed to evaluate the impact of 18F-FDG PET status on disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) in neuroendocrine tumor (NET) patients receiving PRRT. We searched the MEDLINE, Embase, Cochrane Library, and Web of Science databases up to July 2020 and used the Newcastle-Ottawa scale (NOS) criteria to assess quality/risk of bias. A total of 5091 articles were screened. In 12 studies, 1492 unique patients with NETs of different origins were included. The DCR for patients with negative 18F-FDG PET status prior to PRRT initiation was 91.9%, compared to 74.2% in patients with positive 18F-FDG PET status (random effects odds ratio (OR): 4.85; 95% CI: 2.27–10.36). Adjusted analysis of pooled hazard ratios (HRs) confirmed longer PFS and OS in NET patients receiving PRRT with negative 18F-FDG PET (random effects HR:2.45; 95%CIs: 1.48–4.04 and HR:2.25; 95% CIs:1.55–3.28, respectively). In conclusion, 18F-FDG PET imaging prior to PRRT administration appears to be a useful tool in NET patients to predict tumor response and survival outcomes and a negative FDG uptake of the tumor is associated with prolonged PFS and OS.
USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer
Authors: Kosinsky Robyn Laura , Saul Dominik , Ammer-Herrmenau Christoph , Faubion William A. , Neesse Albrecht , Johnsen Steven A.
Published: April 2021

As a member of the 11-gene “death-from-cancer” gene expression signature, ubiquitin-specific protease 22 (USP22) has been considered an oncogene in various human malignancies, including colorectal cancer (CRC). We recently identified an unexpected tumor-suppressive function of USP22 in CRC and detected intestinal inflammation after Usp22 deletion in mice. We aimed to investigate the function of USP22 in intestinal inflammation as well as inflammation-associated CRC. We evaluated the effects of a conditional, intestine-specific knockout of Usp22 during dextran sodium sulfate (DSS)-induced colitis and in a model for inflammation-associated CRC. Mice were analyzed phenotypically and histologically. Differentially regulated genes were identified in USP22-deficient human CRC cells and the occupancy of active histone markers was determined using chromatin immunoprecipitation. The knockout of Usp22 increased inflammation-associated symptoms after DSS treatment locally and systemically. In addition, Usp22 deletion resulted in increased inflammation-associated colorectal tumor growth. Mechanistically, USP22 depletion in human CRC cells induced a profound upregulation of secreted protein acidic and rich in cysteine (SPARC) by affecting H3K27ac and H2Bub1 occupancy on the SPARC gene. The induction of SPARC was confirmed in vivo in our intestinal Usp22-deficient mice. Together, our findings uncover that USP22 controls SPARC expression and inflammation intensity in colitis and CRC.
The Influence of Anti-Diabetic Drugs on Prostate Cancer
Authors: Knura Miłosz , Garczorz Wojciech , Borek Adam , Drzymała Franciszek , Rachwał Krystian , George Kurian , Francuz Tomasz
Published: April 2021

The incidences of prostate cancer (PC) and diabetes are increasing, with a sustained trend. The occurrence of PC and type 2 diabetes mellitus (T2DM) is growing with aging. The correlation between PC occurrence and diabetes is noteworthy, as T2DM is correlated with a reduced risk of incidence of prostate cancer. Despite this reduction, diabetes mellitus increases the mortality in many cancer types, including prostate cancer. The treatment of T2DM is based on lifestyle changes and pharmacological management. Current available drugs, except insulin, are aimed at increasing insulin secretion (sulfonylureas, incretin drugs), improving insulin sensitivity (biguanides, thiazolidinediones), or increasing urinary glucose excretion (gliflozin). Comorbidities should be taken into consideration during the treatment of T2DM. This review describes currently known information about the mechanism and impact of commonly used antidiabetic drugs on the incidence and progression of PC. Outcomes of pre-clinical studies are briefly presented and their correlations with available clinical trials have also been observed. Available reports and meta-analyses demonstrate that most anti-diabetic drugs do not increase the risk during the treatment of patients with PC. However, some reports show a potential advantage of treatment of T2DM with specific drugs. Based on clinical reports, use of metformin should be considered as a therapeutic option. Moreover, anticancer properties of metformin were augmented while combined with GLP-1 analogs.
hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells
Authors: Romaniuk-Drapała Aleksandra , Totoń Ewa , Konieczna Natalia , Machnik Marta , Barczak Wojciech , Kowal Dagmar , Kopczyński Przemysław , Kaczmarek Mariusz , Rubiś Błażej
Published: April 2021

Telomerase is known to contribute to telomere maintenance and to provide cancer cell immortality. However, numerous reports are showing that the function of the enzyme goes far beyond chromosome ends. The study aimed to explore how telomerase downregulation in MCF7 and MDA-MB-231 breast cancer cells affects their ability to survive. Consequently, sensitivity to drug resistance, proliferation, and adhesion were assessed. The lentiviral-mediated human telomerase reverse transcriptase (hTERT) downregulation efficiency was performed at gene expression and protein level using qPCR and Western blot, respectively. Telomerase activity was evaluated using the Telomeric Repeat Amplification Protocol (TRAP) assay. The study revealed that hTERT downregulation led to an increased sensitivity of breast cancer cells to doxorubicin which was demonstrated in MTT and clonogenic assays. During a long-term doubling time assessment, a decreased population doubling level was observed. Interestingly, it did not dramatically affect cell cycle distribution. hTERT downregulation was accompanied by an alteration in β1-integrin- and by focal adhesion kinase (FAK)-driven pathways together with the reduction of target proteins phosphorylation, i.e., paxillin and c-Src. Additionally, autophagy activation was observed in MDA-MB-231 cells manifested by alternations in Atg5, Beclin 1, LC3II/I ratio, and p62. These results provide new evidence supporting the possible therapeutic potential of telomerase downregulation leading to induction of autophagy and cancer cells elimination.
Perspective: Treatment for Disease Modification in Chronic Neurodegeneration
Authors: Müller Thomas , Mueller Bernhard Klaus , Riederer Peter
Published: April 2021

Symptomatic treatments are available for Parkinson’s disease and Alzheimer’s disease. An unmet need is cure or disease modification. This review discusses possible reasons for negative clinical study outcomes on disease modification following promising positive findings from experimental research. It scrutinizes current research paradigms for disease modification with antibodies against pathological protein enrichment, such as α-synuclein, amyloid or tau, based on post mortem findings. Instead a more uniform regenerative and reparative therapeutic approach for chronic neurodegenerative disease entities is proposed with stimulation of an endogenously existing repair system, which acts independent of specific disease mechanisms. The repulsive guidance molecule A pathway is involved in the regulation of peripheral and central neuronal restoration. Therapeutic antagonism of repulsive guidance molecule A reverses neurodegeneration according to experimental outcomes in numerous disease models in rodents and monkeys. Antibodies against repulsive guidance molecule A exist. First clinical studies in neurological conditions with an acute onset are under way. Future clinical trials with these antibodies should initially focus on well characterized uniform cohorts of patients. The efficiency of repulsive guidance molecule A antagonism and associated stimulation of neurogenesis should be demonstrated with objective assessment tools to counteract dilution of therapeutic effects by subjectivity and heterogeneity of chronic disease entities. Such a research concept will hopefully enhance clinical test strategies and improve the future therapeutic armamentarium for chronic neurodegeneration.
How Do the Cultural Dimensions of Climate Shape Our Understanding of Climate Change?
Authors: Alexandra Jason
Published: April 2021

Climatic events express the dynamics of the Earth’s oceans and atmosphere, but are profoundly personal and social in their impacts, representation and comprehension. This paper explores how knowledge of the climate has multiple scales and dimensions that intersect in our experience of the climate. The climate is objective and subjective, scientific and cultural, local and global, and personal and political. These divergent dimensions of the climate frame the philosophical and cultural challenges of a dynamic climate. Drawing on research into the adaptation in Australia’s Murray Darling Basin, this paper outlines the significance of understanding the cultural dimensions of the changing climate. This paper argues for greater recognition of the ways in which cultures co-create the climate and, therefore, that the climate needs to be recognised as a socio-natural hybrid. Given the climate’s hybrid nature, research should aim to integrate our understanding of the social and the natural dimensions of our relationships to a changing climate.
Investigations on the Diffusion of Platinum between CMSX-4 Superalloy and Platinum-Enriched Bond Coat
Authors: Bai Mingwen , Chen Ying , Xiao Ping
Published: April 2021

The depletion of Pt in Pt-enriched bond coats due to inter-diffusion with superalloys has been a critical concern for the long-term oxidation resistance of thermal barrier coatings. This study investigated the diffusion behaviour of Pt between CMSX-4 superalloys and two commercial Pt-enriched bond coats comprising intermetallic γ′/γ-phase or β-phase, with the aim to understand the mechanism that leads to the depletion of Pt at high temperatures. The results demonstrated that the diffusion of Pt in superalloy disrupts its phase equilibrium, causes a significant lattice parameter misfit between the γ-phase and γ′-phase, and results in the formation of large γ′-grains with irregular shapes and random orientations. In addition, by using the Thermo-Calc software, Pt was found to have negative chemical interactions with both Al and Ta that stabilise Pt by decreasing its chemical activity. The depletion of Al due to the growth of Al2O3 scale during oxidation increases the activity of Pt and therefore accelerates the inwards depletion of Pt towards superalloys.
Crystalline AlN Interfacial Layer on GaN Using Plasma-Enhanced Atomic Layer Deposition
Authors: Hwang Il-Hwan , Kang Myoung-Jin , Cha Ho-Young , Seo Kwang-Seok
Published: April 2021

In this study, we report on the deposition of a highly crystalline AlN interfacial layer on GaN at 330 °C via plasma-enhanced atomic layer deposition (PEALD). Trimethylaluminum (TMA) and NH3 plasma were used as the Al and N precursors, respectively. The crystallinity and mass density of AlN were examined using X-ray diffraction (XRD) and X-ray reflectivity (XRR) measurements, respectively, and the chemical bonding states and atomic concentrations of the AlN were determined by X-ray photoelectron spectroscopy (XPS). The AlN/n-GaN interface characteristics were analyzed using TOF-SIMS and STEM, and the electrical characteristics of the AlN were evaluated using metal-insulator-semiconductor (MIS) capacitors. The PEALD process exhibited high linearity between the AlN thickness and the number of cycles without any incubation period, as well as a low carbon impurity of less than 1% and high crystal quality even at a low deposition temperature of 330 °C. Moreover, the GaN surface oxidation was successfully suppressed by the AlN interfacial layer. Furthermore, enhanced electrical characteristics were achieved by the MIS capacitor with AlN compared to those achieved without AlN.
Rheological Behavior of Warm Mix Asphalt Modified with Foaming Process and Surfactant Additive
Authors: Lu Guoyang , Zhang Shaowei , Xu Shaofeng , Dong Niya , Yu Huayang
Published: April 2021

Surfactants are frequently used to improve the engineering performances of foamed bitumen. Additionally, the foaming process can also perform a significant influence on the foam characteristics and rheological properties of foamed bitumen. However, rare research investigates the synergistic effect of both surfactant and foaming process on the engineering properties of foamed bitumen. To fill the gap, this research investigated the synergistic effect of surfactant and foaming process on the foaming characteristics and rheological properties of foamed bitumen. Based on the experimental results, the synergistic effect shows a significant effect on improving the half-life of foamed bitumen, which reached up to 69 s when 6% foaming Evotherm-DAT content was used. In addition, the foaming temperature also has a significant effect on the foaming characteristics. This study shows that the best foaming conditions can be achieved when the foaming temperature and Evotherm-DAT content are 170 °C and 8%, respectively. Based on the study of synergistic effect, the engineering performances of surfactant foamed bitumen were further characterized in this research, for instance, the enhancement in high-temperature performance and fatigue resistance, and the improvement in workability. Generally, the results of this study have greatly promoted the application of surfactant foam bitumen in the engineering practice.
A Comparative Analysis of the Diets of a Genus of Freshwater Turtles across Africa
Authors: Luiselli Luca , Demaya Gift Simon , Benansio John Sebit , Petrozzi Fabio , Akani Godfrey C. , Eniang Edem A. , Ajong Stephanie N. , Di Vittorio Massimiliano , Amadi NioKing , Dendi Daniele
Published: April 2021

Pelusios (Testudines: Pleurodira) is an Afrotropical endemic genus of freshwater turtles that have adapted to a variety of habitats, with savannahs and forests being their two main habitat types. Although considered generally carnivorous, these turtles have rarely been subjected to detailed field surveys for determining their quantitative diet. In this paper, by using both the literature and original data, we analyze the diet of several Pelusios populations: three P. adansonii populations from South Sudan, one P. nanus from Zambia, seven P. castaneus from Nigeria, Benin and Togo, and four P. niger from Nigeria. All species were omnivorous but with a clear preponderance of the prey items being of animal origin (e.g., amphibians, fish, arthropods and annelids). Saturation curves revealed that the diet composition of all the surveyed populations was adequately assessed, and the diversity profiles indicated that all the populations were relatively similar in terms of overall dietary diversity. General Linear Models (GLM) showed a negative effect of vegetation cover on Anura adult consumption by turtles, and showed that the frequencies of Anura tadpoles, fish, reptiles and birds on Pelusios diets increased with the increase in vegetation cover. The GLM model also showed positive effects of individual body size on algae, Bivalvia, reptiles, birds and small mammal consumption by turtles, and underlined that the predation on Arachnida decreased with the increase in turtle body size. In all species, there were no significant intersexual dietary differences, whereas there were substantial ontogenetic dietary changes in three out of four species. Small-sized individuals of P. castaneus, P. niger and P. adansonii tended to feed mainly upon insects, with the adults also taking many fish and adult frogs, and in the case of P. niger, also birds and small mammals. Conversely, in P. nanus, the diet composition did not vary substantially from the juvenile to the adult age. All species appeared substantially generalist in terms of their diet composition, although the effects of season (wet versus dry) were not adequately assessed by our study.
Von Willebrand Factor Multimers and the Relaxation Response: A One-Year Study
Authors: Dal Lin Carlo , Acquasaliente Laura , Iliceto Sabino , De Filippis Vincenzo , Vitiello Giuseppe , Tona Francesco
Published: April 2021

Background and aim: Mental stress represents a pivotal factor in cardiovascular diseases. The mechanism by which stress produces its deleterious ischemic effects is still under study but some of the most explored pathways are inflammation, endothelial function and balancing of the thrombotic state. In this scenario, von Willebrand factor (vWF) is a plasma glycoprotein best known for its crucial hemostatic role, also acting as key regulatory element of inflammation, being released by the activated vascular endothelium. Antistress techniques seem to be able to slow down inflammation. As we have recently verified how the practice of the Relaxation Response (RR), which counteracts psychological stress, causes favorable changes in some inflammatory genes’ expressions, neurotransmitters, hormones, cytokines and inflammatory circulating microRNAs with coronary endothelial function improvement, we aimed to verify a possible change even in serum levels of vWF. Experimental procedure: We measured vWF multimers and the total protein carbonyl contents in the sera of 90 patients with ischemic heart disease (and 30 healthy controls) immediately before and after an RR session, three times (baseline, 6 months, 12 months), during a one-year follow-up study. Results: According to our data, large vWF multimers decrease during the RR, as does the plasma total carbonyl content. Conclusion: vWF levels seem to vary rapidly between anti-inflammatory and antithrombotic behaviors dependent on psychological activity, leading to relaxation and also possibly changes in its quaternary structure.
Virtual Simulations of a New Construction of the Artificial Shaft Bottom (Shaft Safety Platform) for Use in Mine Shafts
Authors: Kamiński Paweł , Dyczko Artur , Prostański Dariusz
Published: April 2021

The deepening of a mine shaft is a difficult and dangerous operation. Moreover, it requires the continuous operation of the shaft during the process of deepening. Because of this, it is necessary to leave the plug on the shaft bottom or install an artificial shaft bottom. The main task of an artificial shaft bottom is to provide safety from falling objects for the employees working on the shaft bottom. Many solutions for shaft safety platforms have been used in Polish mines over the years. A new construction of the artificial shaft bottom consists of using layers of highly durable net. It allows a reduction in the construction weight as well as the installation time. This article presents a new construction of an artificial shaft bottom and the simulations and calculations that confirm the possibility of its application to mine shafts during their deepening.
Numerical Analyses on the Stability of a Deep Coalmine Roadway Passing through a Fault Zone: A Case Study of the Gugui Coalfield in China
Authors: Kang Yongshui , Hou Congcong , Liu Jingyi , Geng Zhi , Chen Jianben , Liu Bin
Published: April 2021

Massive deformation often occurs when deep coalmine roadways pass through a fault zone due to the poor integrity of rock mass and high tectonic stress. To study deformation characteristics of the surrounding rock in the fault zone of a coalmine, a roadway passing through the FD1041 fault zone in China’s Gugui coalfield was investigated in this research. The geo-stress characteristics of this fault zone were analyzed based on the Mohr failure theory. Furthermore, a three-dimensional model for the experimental roadway in the FD1041 fault zone was built and calculated by a numerical program based on the distinct element method. Stability conditions of the roadway, using several types of support methods, were calculated and compared. Calculation results indicated that pre-grouting provides favorable conditions for the stability of a roadway in a fault zone. Finally, an optimized support strategy was proposed and implemented in the experimental roadway. Monitored results demonstrated that the optimized support strategy is appropriate for this fault zone.
Research on the Non-Contact Pollution Monitoring Method of Composite Insulator Based on Space Electric Field
Authors: Zhang Dongdong , Xu Hong , Liu Jin , Yang Chengshun , Huang Xiaoning , Zhang Zhijin , Jiang Xingliang
Published: April 2021

Through spatial electric field monitoring, it is expected to realize insulator pollution condition monitoring and contamination flashover warning in a non-contact way. Therefore, in this paper, the spatial electric field distribution characteristics of 110 kV composite insulators are simulated, where the effects of different surface states and their discharge levels on the spatial electric field of insulators are analyzed. On this basis, a non-contact monitoring method for composite insulator pollution based on the spatial electric field is proposed. The results show that there are significant differences in the spatial electric field of the composite insulator among three conditions, namely cleaning, pollution layer wetting, and dry band arcing. Increases of pollution layer wetting and dry band arcing would lead to an increase of the amplitude of the spatial electric field of the insulator. Verification experiments well indicated that it is feasible to identify the degree of pollution layer wetting as well as dry band arcing of the insulator string by fixed-point monitoring, the spatial electric field signal at the cross-strand of d = 0.5 m and directly opposite the last three positions. Research results can provide references for the online monitoring of overhead line polluted insulators and its flashover warning.
Analysis of PV Subsidy Schemes, Installed Capacity and Their Electricity Generation in Japan
Authors: Knüpfer Kristina , Dumlao Samuel Matthew G. , Esteban Miguel , Shibayama Tomoya , Ishihara Keiichi N.
Published: April 2021

Solar PV capacity growth in Japan has been facilitated by a number of government schemes that have been implemented since 1994. Publicly available capacity data are provided by a number of agencies and organisations at various resolutions and at different stages within these schemes. This study provides a comprehensive review of solar PV data sources in Japan between 1994 and 2019, as well as an introduction to the subsidy schemes and organisations involved in scheme management and data collection in Japan. As a result, the authors produced their own dataset of installed capacities and generation across time for the various regions. Lastly, this study provides insights and recommendations to policy makers regarding opportunities for improving the accessibility and quality of data from a user perspective and to enhance Japan’s presence in international research.
The Analysis of a Prototype Installation for Biogas Production from Chosen Agricultural Substrates
Authors: Borek Kinga , Romaniuk Wacław , Roman Kamil , Roman Michał , Kuboń Maciej
Published: April 2021

Methane production by fermentation is a complex biochemical process, in which micromolecular organic substances are broken down by anaerobic bacteria into simple stabilized chemicals—mainly methane CH4 and carbon dioxide CO2. The organic matter of the slurry consists mainly of fats, proteins and carbohydrates. As a result of biochemical changes in the process of anaerobic decomposition, some of this matter is mineralized to simple chemical compounds. Cattle and pig husbandry offers enormous potential for useable biogas plant substrates. As a result of the constantly increasing amounts of animal husbandry products, and increasingly stringent environmental protection requirements aimed at reusing natural fertilizers, it is necessary to look for alternative processing methods. The need for efficiency in obtaining biogas from substrates (e.g., manure) was met by the laboratory stand presented in this article, for which the Polish patent No. 232200 was obtained. The new technology also allows leaching of the organic liquid, e.g., from manure, and subjecting it to methane fermentation. The solution allows the individual elements of the technological line that determine the fermentation process to be tested under laboratory conditions. It also allows testing of the substrates in terms of fermentation, to determine their physical and chemical characteristics, and then to characterize the fermentation process in terms of the quality and quantity of the resulting biogas and the quality of post-fermentation residues. Compressing biogas for local distribution was also proposed. As part of the research, using a laboratory stand, the organic matter was leached from manure, for the purpose of biogas production. In addition, the biogas yield from manure at varying degrees of maturity was assessed. The best properties in terms of biogas yield forecasting were demonstrated by manure composted for 4–8 weeks.
Investigating the Effects of Ultrasonic Frequency and Membrane Technology on Biodiesel Production from Chicken Waste
Authors: Haghighi Seyyedeh Faezeh Mirab , Parvasi Payam , Jokar Seyyed Mohammad , Basile Angelo
Published: April 2021

In this study, the experiments were carried out under different operating conditions to evaluate the effect of ultrasound waves on biodiesel production from chicken feet oil. A two-step esterification–transesterification mechanism was employed to improve the biodiesel quality. The continuous (methanol-to-oil molar ratio and KOH catalyst amount) and discrete (frequencies, 25 and 45 kHz) variables were investigated using the experimental design method. The five-level three-factor response surface method (RSM) was assisted to optimize the biodiesel synthesis variables. Applying RSM based on the central composite design (CCD), a polynomial equation was fitted to the experimental data with the aid of Design-Expert software. The model accuracy was checked by analysis of variance (ANOVA). The results showed the highest yield of 89.74% could be achieved by using an M/O molar ratio of 12, a KOH concentration of 1 wt%, and an ultrasound frequency of 45 kHz. Finally, a mathematical model of biodiesel production in a membrane system was developed. The reaction rate constant was calculated as a function of ultrasonic frequency. Compared with the conventional method, the membrane system has significantly improved chicken feet biodiesel production’s reaction rate. The membrane is more effective at higher frequencies than at lower ones.
Application and Design Aspects of Ground Heat Exchangers
Authors: Boban Luka , Miše Dino , Herceg Stjepan , Soldo Vladimir
Published: April 2021

With the constant increase in energy demand, using renewable energy has become a priority. Geothermal energy is a widely available, constant source of renewable energy that has shown great potential as an alternative source of energy in achieving global energy sustainability and environment protection. When exploiting geothermal energy, whether is for heating or cooling buildings or generating electricity, a ground heat exchanger (GHE) is the most important component, whose performance can be easily improved by following the latest design aspects. This article focuses on the application of different types of GHEs with attention directed to deep vertical borehole heat exchangers and direct expansion systems, which were not dealt with in detail in recent reviews. The article gives a review of the most recent advances in design aspects of GHE, namely pipe arrangement, materials, and working fluids. The influence of the main design parameters on the performance of horizontal, vertical, and shallow GHEs is discussed together with commonly used performance indicators for the evaluation of GHE. A survey of the available literature shows that thermal performance is mostly a point of interest, while hydraulic and/or economic performance is often not addressed, potentially resulting in non-optimal GHE design.
A Method to Avoid Underestimated Risks in Seismic SUPSA and MUPSA for Nuclear Power Plants Caused by Partitioning Events
Authors: Jung Woo Sik
Published: April 2021

Seismic probabilistic safety assessment (PSA) models for nuclear power plants (NPPs) have many non-rare events whose failure probabilities are proportional to the seismic ground acceleration. It has been widely accepted that minimal cut sets (MCSs) that are calculated from the seismic PSA fault tree should be converted into exact solutions, such as binary decision diagrams (BDDs), and that the accurate seismic core damage frequency (CDF) should be calculated from the exact solutions. If the seismic CDF is calculated directly from seismic MCSs, it is drastically overestimated. Seismic single-unit PSA (SUPSA) models have random failures of alternating operation systems that are combined with seismic failures of components and structures. Similarly, seismic multi-unit PSA (MUPSA) models have failures of NPPs that undergo alternating operations between full power and low power and shutdown (LPSD). Their failures for alternating operations are modeled using fraction or partitioning events in seismic SUPSA and MUPSA fault trees. Since partitioning events for one system are mutually exclusive, their combinations should be excluded in exact solutions. However, it is difficult to eliminate the combinations of mutually exclusive events without modifying PSA tools for generating MCSs from a fault tree and converting MCSs into exact solutions. If the combinations of mutually exclusive events are not deleted, seismic CDF is underestimated. To avoid CDF underestimation in seismic SUPSAs and MUPSAs, this paper introduces a process of converting partitioning events into conditional events, and conditional events are then inserted explicitly inside a fault tree. With this conversion, accurate CDF can be calculated without modifying PSA tools. That is, this process does not require any other special operations or tools. It is strongly recommended that the method in this paper be employed for avoiding CDF underestimation in seismic SUPSAs and MUPSAs.
Forecasting and Modelling the Uncertainty of Low Voltage Network Demand and the Effect of Renewable Energy Sources
Authors: Alasali Feras , Foudeh Husam , Ali Esraa Mousa , Nusair Khaled , Holderbaum William
Published: April 2021

More and more households are using renewable energy sources, and this will continue as the world moves towards a clean energy future and new patterns in demands for electricity. This creates significant novel challenges for Distribution Network Operators (DNOs) such as volatile net demand behavior and predicting Low Voltage (LV) demand. There is a lack of understanding of modern LV networks’ demand and renewable energy sources behavior. This article starts with an investigation into the unique characteristics of householder demand behavior in Jordan, connected to Photovoltaics (PV) systems. Previous studies have focused mostly on forecasting LV level demand without considering renewable energy sources, disaggregation demand and the weather conditions at the LV level. In this study, we provide detailed LV demand analysis and a variety of forecasting methods in terms of a probabilistic, new optimization learning algorithm called the Golden Ratio Optimization Method (GROM) for an Artificial Neural Network (ANN) model for rolling and point forecasting. Short-term forecasting models have been designed and developed to generate future scenarios for different disaggregation demand levels from households, small cities, net demands and PV system output. The results show that the volatile behavior of LV networks connected to the PV system creates substantial forecasting challenges. The mean absolute percentage error (MAPE) for the ANN-GROM model improved by 41.2% for household demand forecast compared to the traditional ANN model.
Editorial: REDD+: Protecting Climate, Forests and Livelihoods
Authors: Pearson Timothy R.H.
Published: April 2021

REDD+ is moving beyond readiness and piloting into real implementation, where measured and verified emission reductions can result in payments to countries or subnational governments [...]
Seasonal Photosynthesis and Carbon Assimilation of Dynamics in a Zelkova serrata (Thunb.) Makino Plantation
Authors: Chen Chung-I , Wang Ya-Nan , Lin Heng-Hsun , Wang Ching-Wen , Yu Jui-Chu , Chen Yung-Chih
Published: April 2021

As anthropogenic greenhouse gas emissions intensify global climate change, plantations have become an important tool to mitigate atmospheric CO2. Our aim in this study was to estimate carbon assimilation and clarify the impact of environmental factors on the photosynthesis of Zelkova serrata (Thunb.) Makino, an important plantation species that is extensively planted in low altitude regions of East Asia. We measured monthly gas exchange parameters and leaf area index to estimate carbon assimilation. The results showed that gas exchange was significantly affected by vapor pressure deficit and temperature, especially in the dry season, and both photosynthetic rate and carbon assimilation decreased. Lower daytime assimilation and higher nighttime respiration during the dry season, which caused a 43% decrease in carbon assimilation in Z. serrata plantations. Z. serrata exhibited lower photosynthetic rate and lower carbon assimilation following planting in a tropical monsoon climate area. Therefore, the effects of extreme weather such as high temperature and vapor pressure deficit on Z. serrata forest carbon budget could be stronger in the future. Leaf area showed seasonal variation, and severe defoliation was caused by a typhoon in the summer. The annual carbon assimilation was estimated at 3.50 Mg C ha−1 year−1 in the study area.
Photosynthetic Product Allocations to the Organs of Pinus massoniana Are Not Affected by Differences in Synthesis or Temporal Variations in Translocation Rates
Authors: Deng Xiuxiu , Shi Zheng , Zeng Lixiong , Lei Lei , Xin Xuebing , Pei Shunxiang , Xiao Wenfa
Published: April 2021

Photosynthesis and the allocation of photosynthetic products are the two main factors that determine plant growth. To understand the growth and productivity of Pinus massoniana Lamb., the diurnal changes in photosynthetic rate were continuously monitored. Furthermore, the translocation and allocation of the photosynthetic products synthesized in the morning and afternoon were explored using 13C pulse labeling. The results showed that: (1) on sunny days, the diurnal variation of the net photosynthetic rate showed a “double peak” curve, with an obvious “a depression” when temperatures were highest and humidity lowest. On cloudy days, it showed an irregular “jagged” curve, which was curve consistent with the variations in photosynthetically active radiation (PAR). Meanwhile, the photosynthetic rate changed with the transient changes in environmental factors such as PAR, temperature, and humidity. (2) The mean value of the net photosynthetic rate in the morning was higher than in the afternoon, and the response of the net photosynthetic rate to environmental change (PAR, temperature, humidity, and CO2 concentration) in the morning was greater than that in the afternoon. (3) The translocation of photosynthetic products synthesized in the afternoon was faster than that in the morning. Shortly after synthesis of photosynthetic products, the translocation of products synthesized in the morning tended toward upper organs (including current-year leaves and 1-year leaves), while the translocation of products synthesized in the afternoon decreased in the upper organs. However, after 15 days of 13C pulse labeling, the allocation of the photosynthetic products synthesized in the morning and afternoon tended to be the same. These results indicate that the differences in the photosynthetic products synthesized and the temporal differences in the translocation rates did not affect the final allocation of the photosynthetic products in the various organs of the P. massoniana. These results improve our knowledge of the functional phases of P. massoniana during the diurnal cycle.
Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882)
Authors: Erblang Mégane , Sauvet Fabien , Drogou Catherine , Quiquempoix Michaël , Van Beers Pascal , Guillard Mathias , Rabat Arnaud , Trignol Aurélie , Bourrilhon Cyprien , Erkel Marie-Claire , Léger Damien , Thomas Claire , Gomez-Merino Danielle , Chennaoui Mounir
Published: April 2021

This study investigated whether four single nucleotide polymorphisms (SNPs) moderated caffeine effects on vigilance and performance in a double-blind and crossover total sleep deprivation (TSD) protocol in 37 subjects. In caffeine (2 × 2.5 mg/kg/24 h) or placebo-controlled condition, subjects performed a psychomotor vigilance test (PVT) and reported sleepiness every six hours (Karolinska sleepiness scale (KSS)) during TSD. EEG was also analyzed during the 09:15 PVT. Carriers of the TNF-α SNP A allele appear to be more sensitive than homozygote G/G genotype to an attenuating effect of caffeine on PVT lapses during sleep deprivation only because they seem more degraded, but they do not perform better as a result. The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect. Higher EEG theta activity related to sleep deprivation was observed in mutated TNF-α, PER3, and COMT carriers, in the placebo condition particularly. In conclusion, there are genetic influences on neurobehavioral impairments related to TSD that appear to be attenuated by caffeine administration. (NCT03859882).
Validity and Reliability of Self-Assessment Tool for Risk Prioritization Following Exposure to Tuberculosis in a Hospital Setting
Authors: Sirinapakul Piyapong , Chaiear Naesinee , Krisorn Phanumas
Published: April 2021

The Modified Self-Assessment (MSA) and Present Self-Assessment (PSA) forms are questionnaires used to prioritize the risk of infection of health workers exposed to tuberculosis (TB) in Srinagarind Hospital in Thailand. As MSA was developed from PSA, the validity and reliability of MSA need to be assessed. The research aim is to examine the content validity of MSA and to assess the respective reliability of MSA and PSA vis-à-vis expert opinion. Seven experts determined the content validity index (CVI) of MSA. MSA and PSA were used to prioritize the TB contact of 108 subjects, and we compared the result with the risk assessed by the experts. The respective Kappa agreements between MSA and PSA and the experts were used to assess reliability. The result of the content validity index revealed that MSA had I-CVI > 0.83 for all questions and an S-CVI/Ave above 0.90 for all factors. The Kappa agreement of contact priority between MSA and the experts was 0.80; it was 0.58 between PSA and the experts. MSA can, thus, be used to prioritize contact with tuberculosis in Srinagarind Hospital. MSA is a valid risk communication tool for aerosol-generating procedures. Further study should be conducted in other hospitals, and the number of participants should be increased in order to come to a concrete result.
Assessment of Saudi Mother’s Knowledge and Attitudes towards Childhood Diarrhea and Its Management
Authors: Alghadeer Sultan , Syed Wajid , Alhossan Abdulaziz , Alrabiah Ziyad , Babelghaith Salmeen D. , Al Arifi Mohamed N. , Alwhaibi Abdulrahman
Published: April 2021

This study evaluates the knowledge, attitude of Saudi mothers towards diarrhea in their children and its management at home. Online cross-sectional validated online surveys, targeting Saudi mothers who are living in Saudi Arabia, are used to collect data from the beginning of March to the end of April 2019. Our results show that a total of 1140 mothers (52.1% of them were housewives) participated in the study. Approximately 40.3% of participating mothers believed that childhood diarrhea is a major problem in the Saudi community; however, almost 23% of the participants were unable to identify any critical sign of severe diarrhea, and around 66% falsely stated that diarrhea is caused by teething. Although 62% of our participating mothers knew about oral rehydration therapy (ORS), only 23.5% of them used it for their children. Adequate knowledge about the critical signs, causes, transmission, prevention, and management of childhood diarrhea should be applied in simple language to communicate the health-related information clearly.
The Variation of Heavy Metals Bioavailability in Sediments of Liujiang River Basin, SW China Associated to Their Speciations and Environmental Fluctuations, a Field Study in Typical Karstic River
Authors: Hao Yupei , Miao Xiongyi , Liu Hongwei , Miao Dan
Published: April 2021

The bioavailability of heavy metals (HMs) in sediments is closely related to the security of the aquatic environment, but their impacts are poorly researched, particularly in karstic rivers. Therefore, Liujiang River Basin was taken as an example in this study. Seven HMs were analyzed to determine the bioavailability and speciations of HMs in sediments. Moreover, the impacts of environmental factors on HMs were identified. The obtained results suggested that HMs in the sediments are all within their permissible exposure limit (PEL), but Cd and Zn are significantly higher than the soil baseline. Most HMs were found to be in a residual fraction, while their exchangeable fraction was found to be in an extremely low ratio. HMs in bioavailable parts are significantly higher than in the exchangeable and carbonate-bound phases but lower than in the non-residual phase, which demonstrated that HM bioavailability is not confined to the exchangeable and carbonate-bound phases. The correlation coefficients commonly decreased with decreasing speciation ratios, which suggested that the overall bioavailability of metals should be determined by speciation ratios instead of speciations themselves. Noteworthily, most HMs in the residual form were found to be significantly correlated with their overall bioavailability, which highlighted the potential bioavailability of residual form. The non-correlations between pH, electrical conductivity (EC), total dissolved solids (TDS), and HM bioavailability suggested that HMs in the carbonate-bound phase are stable and unsusceptible to environmental variations, while the significant correlations between redox potential (Eh), turbidity, organic matter (OM), main grain size (Mz), and HM bioavailability suggested that HMs in the reducible and oxidizable forms are susceptible to environmental fluctuations. Therefore, the variation of HM bioavailability in karstic rivers is largely regulated by their reducible and oxidizable forms instead of their carbonate-bound form.
Scoping Review on Ageism against Younger Populations
Authors: de la Fuente-Núñez Vânia , Cohn-Schwartz Ella , Roy Senjooti , Ayalon Liat
Published: April 2021

Systematic efforts have been carried out to study ageism against older populations. Less is known about ageism against younger populations, including how it is defined, how it manifests, its effects, and how it can be addressed. A scoping review was conducted aimed at identifying available evidence on these topics. A comprehensive search strategy was used across thirteen databases, including PubMed, EMBASE, and CINAHL. Records were screened by two independent reviewers. Data extraction was done by one rater and independently reviewed by a second rater. Of the 9270 records identified, 263 were eligible for inclusion. Most of the evidence focused on the manifestation of ageism (86%), followed by a focus on the determinants of ageism (17%), available interventions to address ageism (9%), and the effects of ageism (5%). This study points to the inconsistent terminology used to describe ageism against younger populations and the relatively limited theoretical rationale that guides existing studies. It also highlights key research gaps and points to the strengths of existing research.
Spatiotemporal Hotspots of Study Areas in Research of Gastric Cancer in China Based on Web-Crawled Literature
Authors: Wang Zhen , Ren Hongyan , Zhang An , Zhuang Dafang
Published: April 2021

Gastric cancer is a common malignancy worldwide and poses a serious threat to human public health. The difficulty in obtaining epidemiological data limits the development of cross-disciplinary related research. In this study, 99,364 publications on gastric cancer from 1991 to 2019 were obtained using web-crawler technology, and a technical framework for extracting toponyms from these publications was constructed to analyze spatiotemporal hotspots of study areas in gastric cancer research in China. The results showed the following: (1) The accuracy of toponym extraction was greatly improved after eliminating the systematic exclusion words and adding historical toponyms, with a precision of 95.31% and a recall of 94.86%. (2) Gastric cancer research (GCR) and gastric cancer research with toponyms (GCRWT) are attracting increasing amounts of attention. The amount of GCR results published in Chinese and English is gradually leveling off, and the imbalance between those of GCRWT is gradually widening. (3) The spatial distribution of gastric cancer research in China is uneven, and the hotspots are mainly located in the eastern coastal areas. There were huge advances in gastric cancer research at the province/city/county scale in Eastern China, while the central region has only increased research at the county scale. We suggest that gastric cancer research should pay more attention to the central region, which has the highest gastric cancer incidence/mortality. This study provides important clues for research on and investigations of gastric cancer.
Soldier Load Carriage, Injuries, Rehabilitation and Physical Conditioning: An International Approach
Authors: Orr Robin , Pope Rodney , Lopes Thiago Jambo Alves , Leyk Dieter , Blacker Sam , Bustillo-Aguirre Beatriz Sanz , Knapik Joseph J.
Published: April 2021

Soldiers are often required to carry heavy loads that can exceed 45 kg. The physiological costs and biomechanical responses to these loads, whilst varying with the contexts in which they are carried, have led to soldier injuries. These injuries can range from musculoskeletal injuries (e.g., joint/ligamentous injuries and stress fractures) to neurological injuries (e.g., paresthesias), and impact on both the soldier and the army in which they serve. Following treatment to facilitate initial recovery from injuries, soldiers must be progressively reconditioned for load carriage. Optimal conditioning and reconditioning practices include load carriage sessions with a frequency of one session every 10–14 days in conjunction with a program of both resistance and aerobic training. Speed of march and grade and type of terrain covered are factors that can be adjusted to manipulate load carriage intensity, limiting the need to adjust load weight alone. Factors external to the load carriage program, such as other military duties, can also impart physical loading and must be considered as part of any load carriage conditioning/reconditioning program.