bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats
Authors: Smirnova S. L. , Roshchevskaya I. M. , Barchukov V. V. , Tsorin I. B. , Kryzhanovskii S. A.
Published: July 2023

Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which is largely associated with an increased risk of developing malignant diseases of the cardiovascular disease. Search for new drugs, including those exhibiting pronounced antiarrhythmic activity, supposed relevance. Objective. To study the effect of combination therapy with fabomotizole and ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats. Methods. The sequence of depolarization of the atrial epicardium was studied in rats in a translational model of alcoholic cardiomyopathy, which received a combination of fabomotizole and compound ALM-802 daily for 28 days after the end of 24 weeks of alcoholization, or pyrogen-free water intraperitoneally. Results. As a result of the 28-day combined action of fabomotizole and the compound ALM-802 in animals with alcoholic cardiomyopathy, additional areas of early activation in the area of lacunae of the pulmonary veins that form during the 24-week period of alcoholization disappear, the risk of atrial arrhythmias is minimized, and sequential propagation.
Study of the antiarrhythmic activity of linear alkoxyphenylazalkanes in the model of reperfusion arrythmias in rats
Authors: Barchukov V. V. , Stolyaruk V. N. , Tsorin I. B. , Vititnova M. B. , Kryzhanovskii S. А. , Vorobieva T. Yu. , Biryukova V. E. , Mokrov G. V.
Published: July 2023

The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model of reperfusion arrhythmia in rats. It was found that the key requirements for the compounds activity in this model are the use of 2,3,4 trimethoxyphenyl aromatic pharmacophores and the presence of a central nitrogen atom in the linker. The most active compounds were ALM-802 (trihydrochloride N1–(2,3,4-trimethoxybenzyl)-N2– {2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine) and ALM-811 (N1-(2,3,4-trimethoxybenzyl)-N3-{3-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,3-propanediamine trihydrochloride), which significantly prevented the development of ventricular tachycardias and/or ventricular fibrillation.
Сardioprotective agents with biaromatic structure. Part 5. Potassium Kv1.5-channels blockers
Authors: Mokrov G. V.
Published: July 2023

The Kv1.5 potassium channel provides an ultra-rapid delayed rectifier potassium current, IKur, that acts selectively in human atrial cells. This makes selective Kv1.5 blockade a promising approach to control atrial arrhythmias without the adverse ventricular effects associated with classical hERG-subtype potassium channel blockers (Kv11.1). This review considers all currently known Kv1.5-channel blockers with a biaromatic structure and data on their biological properties. For many of the Kv1.5-selective compounds studied, the ability to prevent the development of atrial arrhythmias without affecting ventricular refractoriness was confirmed.
Method for quantitative analysis of the marker substrate ABCB1-protein fexofenadine in Caco-2 cell lysate
Authors: Kopanitsa M. A. , Tranova Yu. S. , Chernykh I. V. , Shchulkin A. V. , Mylnikov P. Yu. , Kalinkina O. V. , Yakusheva E. N.
Published: July 2023

One way to analyze the activity of the ABCB1 protein is to assess the accumulation of its substrate fexofenadine (F.) inside the test cells. The goal is to develop and validate a method for the quantitative analysis of F. in Caco-2 cell lysate using HPLC-MS/MS. Materials and methods. Caco-2 cell lysate was used as a matrix. The analysis was performed on an "Ultimate 3000" chromatograph with a TSQ Fortis triple quadrupole mass detector, a UCT Selectra C18 4.6 mm*100 mm 5 µm column in a gradient elution mode. The mobile phase rate was 0.3 ml/min, the sample volume was 20 µl, the ionization mode was positive, and the internal standard was amantadine (ng/ml). Sample preparation — precipitation of cell lysate protein with acetonitrile. The method was validated for the following parameters: selectivity, linearity, lower limit of quantitation (LLOQ), correctness, precision, sample transfer and sample stability. Results. Chromatograms of the blank lysate of Caco-2 cells showed no peaks with retention times characteristic of F. (5.70 min) and amantadine (3.58 min). NPKO F. was 0.5 ng/ml. F.'s transfer did not exceed 20% of NPKO, and amantadine — 5%. Based on the results of the analysis of three series of calibration standards (0.5; 1; 1.5; 5; 10; 25; 40; 50 ng/ml), linear regression equations were obtained, the correlation coefficients exceeded 0.99. Accuracy and precision were assessed within and between cycles by analyzing F. solutions in the matrix (0.5; 1.5; 25 and 40 ng/ml) within three cycles. The parameters did not exceed 20% for LLPO and 15% for other points. The stability of F. solutions (1.5 and 40 ng/ml) in the lysate was analyzed during storage at room temperature, after 3-fold freezing-thawing, storage at -80 °C for 60 days, after sample preparation and being in the autosampler for 24 hours. The accuracy was within 15% of the nominal values. Conclusions. A method for the quantitative determination of F. in Caco-2 cell lysate using HPLC-MS/MS has been developed and validated.
Seguridad en la plataforma moodle, utilizada por los Institutos Superiores Tecnológicos públicos del Ecuador
Authors: Moreano Guerra Carlos Bladimir , Huera Páez Gisella Brigitte , Pesántez Huanga Celia Marisol , Yadira Guissela Franco Rocha
Published: July 2023

La investigación aborda un diagnóstico de los niveles de seguridad en el trabajo desarrollado en la plataforma Moodle como herramienta principal utilizada en los institutos superiores de educación para el desarrollo de las clases virtuales. Se orientó a identificar deficiencias y vulnerabilidades, que presenta el sistema, para proponer alertas a la comunidad educativa y, con el propósito de que los usuarios, principalmente profesores y tutores puedan tener la certeza de que su información está debidamente protegida. Se realizó experimentos con pruebas en aulas simuladas en el Instituto Superior Tecnológico Sucre determinando algunos tipos de amenazas que ponen en riesgo la accesibilidad y los contenidos de los cursos de las asignaturas dictadas por los profesores. Se encontró que el cambio de rol se puede realizar con relativa facilidad entre los diferentes niveles de usuarios, se puede pasar de estudiante a profesor, estudiante a gestor, y de profesor a gestor o administrador; con esto el estudiante puede tener acceso a los cuestionarios, bancos de preguntas y a las calificaciones almacenadas dentro del aula virtual. Se concluye que el mismo sitio web utilizado por Moodle para la recopilación de fallos puede ser atractivo para los crackers, ellos dispondrían de un período de tiempo para su explotación en perjuicio de los usuarios, mientras se soluciona el problema; cuanto más antigua sea la versión tanto más probable que tenga vulnerabilidades, requiriéndose de una continua actualización y del establecimiento de controles preventivos.
Determinants of Foreign Direct Investment in India and Retail Sector Liberalization: A GMM Estimation
Authors: Manocha R.
Published: July 2023

India has one of the largest retail markets in the world. In order to channelize the huge potential of Indian retail sector and to provide best of the cosmopolitan culture to the fast-growing Indian retail market and to stimulate India’s FDI inflows, the Government of India has systematically liberalized FDI in the retail sector since 2006. The present study incorporates retail sector liberalization measures as one of the institutional changes and tries to empirically examine the impact of institutional changes on India’s FDI inflows. Along with the conventional determinants of FDI, extended institutional variable has been incorporated in order to study the inflows from 21 investing countries for the period 2001-2020. The results were captured by employing fixed effects, random effects, and GMM (two-step) estimation. The study suggested a positive and significant coefficient for extended market size, economic freedom index, and extended institutional variable whereas inflation was found to have a significant and negative impact on India’s FDI inflows.
Self-esteem of acute leukemic children undergoing chemotherapy
Authors: Behiry Fatma M.Z. , Darwish Mirret M. , Hassan Eman A.-F. , Mahmoud Mahmoud H.
Published: July 2023

Background

Acute leukemia is a major malignancy in children. Multiagent chemotherapy protocols are the main treatment option for acute leukemia. Still chemotherapy has a significant effect on children's well-being, improving the physical, psychological, and social status of children, and also, it has a remarkable effect on self-image and self-esteem.

Aim

The aim was to assess self-esteem of acute leukemic children undergoing chemotherapy.

Patients and methods

A descriptive exploratory research design was used. The study was conducted at two pediatric oncology outpatient clinics at Tanta Cancer Center and National Cancer Institute at Cairo University. A purposive sample of 80 children with acute lymphoblastic leukemia was recruited. Their ages were between 10 and 16 years old. A structured interview questionnaire and Coopersmith Self-esteem Inventory were used, and IRB approval was obtained from the National Cancer Institute for performing this study.

Results

The age of half of the children (50%) ranged between 14 and 16 years, with mean±SD age of 13.21±1.62 years. Overall, 61.3% were males. Less than half of the children (47.5%) received intravenous chemotherapy, whereas 46.2% of the children had both oral and intravenous chemotherapy. More than half of the children (62.5%) had low self-esteem regarding general self, whereas the vast majority of children (90%) had low self-esteem regarding their social self-peers. All children had low self-esteem toward their home parents, whereas the highest percent (98.8%) of children had low self-esteem regarding their school academic. The vast majority children (98.8%) had low self-esteem regarding the lie scale. All dimensions of self-esteem were significantly correlated with total score of self-esteem.

Conclusion

Children with acute leukemia undergoing chemotherapy had low self-esteem regarding general self, home parents, school academic, and social peers. Self-esteem was negatively affected among school age and adolescent children with acute leukemia who underwent chemotherapy. Regarding the lie domain, most children always told the truth.

Recommendations

Training programs should be designed and constructed for nurses in how to assess self-esteem for children with acute leukemia. Empowerment program should be directed to children with acute leukemia and their caregivers to improve their self-esteem.
Health profile of pregnant women with asymptomatic bacteriuria
Authors: El Sayed Ezz Reem , El Hamed Azza A.A. , Nabil Aboushady Reda M. , El Rahman Walaa M.A.
Published: July 2023

Background

Urinary tract infections (UTIs) are the most common bacterial infection during pregnancy. UTIs in pregnancy are associated with maternal as well as fetal morbidity. The aim of the current study was to assess the health profile of pregnant women with asymptomatic bacteriuria (ASB).

Design

A descriptive research design was adopted to obtain the stated aim.

Sample

A purposive sample of pregnant women with UTIs without symptoms throughout 1 year but the sample not less than 100 pregnant women was recruited.

Setting

The study was performed at woman's care clinic at Al Kasr Al Ainy University Hospital.

Tools

Two tools were utilized: (a) urine analysis record and (b) structured interviewing questionnaire schedule.

Results

The study findings showed that the mean age of the pregnant women with ASB was 29.00±5.48 years old. Overall, 26% of them could not read and write, and 96% of them were housewives. Regarding place of residence, 82% of the selected sample was from rural areas. Half of the selected sample was multigravida, whereas 55% of them were multipara. Overall, 61% of them had a history of abortion. Furthermore, 86% of the selected sample used new latrine toilet, and 61% had a previous history regarding infection. In addition, 63% of the selected sample used contraceptive methods, and 58% of them had previous normal vaginal delivery. Concerning trimester, 73% were in the third trimester.

Conclusion

The current study's findings revealed that age, cannot read and write, rural areas, housewives, usage of new latrine toilet, multigravida, multipara, history of abortion, normal vaginal delivery, usage of contraceptive methods, history of previous infection, and third trimester were represented the health profile of the pregnant women with ASB that might increase the incidence of a symptomatic bacteriuria infection.

Recommendation

Pregnant women should be made aware regarding personal hygiene through classes on motherhood.
Cooperation Between the USSR and Nicaragua in the Conditions of the Sandinista Revolution
Authors: Baranov A. V.
Published: July 2023

The article defines the preconditions and main directions of cooperation between the USSR and Nicaragua in the conditions of the Sandinista revolution in 1979–1990. The topic of the article is relevant for studies of Soviet foreign policy in Latin America in economic, military, ideological and socio-cultural aspects, and it also allows to identify the prerequisites for the return to cooperation between the Russian Federation and Nicaragua in the post-Soviet period of history. The article applies the paradigm of neorealism in international studies, which makes it possible to determine the resources of influence, interests and institutional framework of the USSR’s foreign policy towards Nicaragua, to compare the declared and real tasks of foreign policy. Comparative-historical and structural-functional methods are used.

The course of the Soviet foreign policy towards revolutionary Nicaragua had both geopolitical and ideological motivations. Nicaragua was a promising springboard for the establishment of revolutionary regimes in other countries of Central America. The country also occupied a key position for the construction of an inter-oceanic canal, an alternative to the Panama Canal. In Soviet literature of the 1980s the Sandinista revolution was seen as national-liberation, anti-imperialist, but not socialist. Soviet experts positively assessed the strategic alliance of the Sandinista National Liberation Front (FSLN) with the supporters of the revolution among the believers. Sandinism was regarded as an effective, albeit controversial, revolutionary ideology. The periodization of the Soviet foreign policy towards Nicaragua during 1979–1990 is substantiated: the establishment of cooperation relations (1979–1981), the highest point in cooperation (1982–1987), the curtailment of cooperation as the national reconciliation policy (1987–early 1990) was unfolding. The main factor in the dynamics of bilateral relations were the strategic interests of the USSR in Central America, which changed dramatically under the influence of perestroika. The defeat of the FSLN in the 1990 elections was largely the result of the Soviet foreign policy deideologization and the collapse of socialism in the Eastern European countries.
Сooperation of Russian and Spanish Researchers Facing the Challenges of Time
Authors: Krivushin I. V.
Published: July 2023

Book Review: Spain and Russia Facing the Challenges of Time. O. Volosyuk (ed.), — Moscow:  Mezhdunarodnye otnoshenia, 2022. — 648 p.
Kings, Buffoons and Philosophers in Diego Velazquez’s Paintings: Russian Perspective
Authors: Silantieva М. V.
Published: July 2023

The author analyses the philosophic and anthropological notions embodied in the works of the great Spanish artist Diego Velázquez. In the author’s opinion, not only written texts have an underlying philosophy of their own, but creations of visual arts just as well. They, therefore, can be a subject to philosophical analysis. It certainly does not mean that they may be literally translated into a verbal text, but that they have a meaning and a message of their own, closely linked in their own way to their historical background, the spirit of the epoch in which they were created. That is what makes them topical for modern thinkers and explorers of visual arts. The author pays special attention to such subjects, constantly present in Velazquez’s works, as «The Mirror» theme, the correlation between the rational and the emotional side of human nature and, consequently, the essence of certain «anthropological constants» and, finally, the problem of human being as bearer of moral values.
NITROGEN FEEDING OF WINTER PEAS AT THE SPRING VEGETATION RE-COVERY STAGE
Authors: BURYKINA Svetlana , SERHIEIEV Leonid , KOHUT Inna , SHARII Victor
Published: July 2023

In a field experiment from 2020–2023 on the southern chernozems of the Odessa region of Ukraine, we studied the effect of the doses and timing of mineral nitrogen application when growing winter peas on the tuberization process and crop productivity. Mineral nitrogen in doses of 30, 45 and 60 kg/ha in the form of ammonium nitrate was applied in different development phases of winter peas under seedbed cultivation: foliar top dressing with urea solutions during the resumption of spring vegetation, the budding phase and the beginning of grain filling. Winter pea of the Enduro variety was sown annually on October 20, with a row spacing of 15 cm and a rate of 1.2 million germinating seeds per hectare. The previous crop was winter wheat. The conditions of the Southern Steppe of Ukraine for winter sown peas were shown for the first time. The introduction of mineral nitrogen at a rate of 30–60 kg/ha into the soil during sowing inhibited the formation of nodules from the active spring growth phase. The mass of nodules on the roots of pea plants decreased by 30–50% compared to the control variant without nitrogen application. The same norms of mineral nitrogen introduced in early spring during the resumption of vegetation on the leaf in the form of aqueous solutions did not have a negative impact on tuberization. The correlation coefficient between the dose of mineral nitrogen and the number and weight of nodules did not exceed 0.37, indicating a weak relationship between these indicators. The share of influence of mineral nitrogen norms did not exceed 13.7%. With this method of application, the nitrogen content in the vegetative mass of winter peas exceeded the control variant by 18–27%.
Criterios para el fortalecimiento de la calidad de servicio al usuario de servicios de educación superior. Caso estudio UF
Authors: Vacacela Conforme1* Lissette Juleysi
Published: July 2023

El presente documento pretende el desarrollo de un análisis sobre la gestión administrativa en satisfacción de calidad del servicio a los estudiantes del Instituto Tecnológico de Formación (ITF). La metodología utiliza un enfoque mixto, recolectando datos mediante un cuestionario a 388 estudiantes, vía internet, estructurado a partir de las dimensiones e indicadores pertinentes a la técnica SERVPERF. Los resultados reportan para la gestión administrativa un 0,981 sobre la satisfacción de la calidad que tiene el estudiante de los servicios que recibe por parte del ITF. Con base a estos resultados se desarrolló la propuesta de creación del Centro de Acompañamiento Estudiantil, que tiene como funciones promover un canal de comunicación entre estudiantes, autoridades y entes administrativos institucionales; y asesoramiento de los estudiantes en diferentes procesos de gestión académica.
The Role of Gender on the Effects of Product Quality Attributes and eWOM on Tourist Visit Decision and Revisit Intention: Agro-Tourism in Aceh
Authors: Muzammil Abdul , Safrika Safrika , Siregar M. Ridha , Kesuma T. Meldi
Published: July 2023

One of the tourism sectors that is currently emerging and becoming a trend in Aceh is agro-industrial tourism in the agricultural and plantation sectors or commonly referred to as agro-tourism. Aceh has quite extraordinary potential to develop this agro-industry-based tourism considering that Aceh has agricultural and plantation land that is quite extensive and fertile. This study aims to analyze how the product quality attributes and eWOM influence the visiting decision of tourists and then its impact on the intention to return to the original place after experiencing the experience of traveling and compare the results based on gender. This study combines two research methods, namely descriptive and quantitative. This study was conducted on 330 tourist that come to visit agro-tourism in Aceh. The sample taken by using purposive sampling technique and the sample data were statistically analyzed using Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM) with second order method and Multiple Group Analysis (MGA) for analysis of gender. Overall, the results showed that product quality attributes and eWOM significantly effects tourist visit decision and revisit intention, and tourist visit decision also significantly effects revisit intention. Based on gender, the analysis results show that male and female are very different. The analysis results show that product quality attributes variable on tourist visit decisions and the effect of eWOM toward tourist visit decisions and revisit intention for male are not significant
Health Locus Of Control And Health Behaviour Among Female Students And Employees In A Nigerian Tertiary Institution
Authors: Oluwafisayo A. ADEBIMPE , F.M. ILEVBARE , A. AKINSULORE , T. OPAKUNLE , S. I. BABATUNDE , O. OJELEYE
Published: July 2023

The study examined the role of health locus of control and health behaviours on women's health.   400 female respondents were recruited employing convenient sampling between ages 18 - 60 years at Obafemi Awolowo University, Ile-Ife, Nigeria. The questionnaire consisted of socio-demographic variables, the adapted version of the Multidimensional Health Locus of Control Scale, and the Health Behaviour Scale. The study assessed the associations between the dimensions of HLOC and health behaviour among women in the institution. Chi-square analysis revealed a significant relationship among the students, academic staff, and non-academic staff population on the internal locus of control scale (X2 (2) 7.4565, p < 0.02). There was also a significant relationship among the two subscales of external locus of control; powerful others      (X2 (2) 6.3818, p < 0.04) and chance (X2 (2) 17.6865, p < 0.00) respectively. Health Enhancing Behaviour was also found to be significant among the population (X2 (2) 9.4420, p < 0.01).  The study concluded that health locus of control and health behaviour had a significant role in women's predisposition towards their health issues.
Vocational Educations and Training (VET) Adoption at Science Techno Park (STP) in the Field of Maritime to Promote Business Incubation and Community Empowerment in Indonesia
Authors: Husna Jazimatul , Syakur Abdul , Wijayanti Ima , Budiastuti Wiratmo Liliek
Published: July 2023

This research aims to adoption of VET in the Indonesian Science Techno Park (STP) to support business incubation and community empowerment in the maritime field. Research and development (R&D) was used in this study to improve STP exploration to more effective and efficient. This research approach uses SOAR analysis to determine STP's strategy to build its future through collaboration, understanding, and action. The approach involves the analysis of relevant documents, observations, and interviews. This research focuses on three important aspects of VET adaptation in the Science and Techno Park (STP) program, are the following: (1) education and training to produce competent personnel; (2) adaptation and transfer of technology to produce innovative products; and (3) becoming a business incubator to produce new entrepreneurs. The results show that STP has developed various VET programs adapted to the maritime sector. These programs have been successful in increasing the skills of the maritime community, helping the community build new business start-ups to increase skills in developing of various fish and seafood processing products, having quality products whose consistency is shown by the results of lab tests, and able to reach market areas with a wide range of marketing in this maritime field in indonesia.
Identification Of Java Agate Elements Using Libs Methods
Authors: Sugito Heri , Khumaeni Ali , Nurhasanah Iis , Bagaskara Angger
Published: July 2023

Agate is a stone that is created due to natural processes from the deposition of fossils and the formation of minerals that combine to become an agate. In essence, agate contains elements contained therein. The content of these elements can be used to distinguish the type of agate. Several methods are used to detect the elemental content of agate, including X-Ray Fluorescence and X-Ray Diffraction methods. In this study, agate will be tested using the LIBS method. The LIBS method is an alternative and effective method for identifying elements from a sample because this method does not require the sample to receive special treatment. Laser plasma optimization is done by varying the laser energy. The higher the value of the laser energy given, the intensity of the elemental spectrum will be higher. The results of the LIBS method show compatibility with the XRF method as a comparative study. The results showed that the elements contained in the agate are the elements Al, Mn, Si, Fe, Mg, Na, and Ca.
Igarapés como espaço educacional não formal para estudantes de uma escola pública no interior do Estado do Amazonas, Brasil
Authors: Gomes Érica Estevao , Coelho Rayciane Campos , Pinheiro Ronaldinho Coelho , Oliveira Rimone dos Santos Córdova , Oliveira dos Santos Edson , Silva de Oliveira Elenilson , De Jesus Silva Agmar José
Published: July 2023

Em consonância com as propostas curriculares do Novo Ensino Médio, da Base Nacional Curricular e do Referencial Curricular Amazonense, torna-se indispensável o emprego de metodologias diferenciadas na escola para promover um ensino contextualizado, interdisciplinar e participativo. Nesse contexto, este trabalho teve por objetivo utilizar os ambientes (poluídos e não poluídos) de igarapés de Benjamin Constant, Amazonas, Brasil, como espaço não formal de ensino e aprendizagem de conceitos de biologia e química para alunos do ensino médio de uma escola púbica local. A pesquisa, de caráter qualitativo, utilizou um questionário semiestruturado para explorar conhecimentos prévios dos estudantes e aprofundar novas habilidades relacionadas à temática da poluição dos igarapés de Benjamin Constant por resíduos sólidos descartados inadequadamente pela população. Verificou-se que 80% dos alunos compreenderam a importância da reciclagem do lixo urbano, mas 20% não sabiam, até então, o significado dessa ação para a preservação do meio ambiente. Para 45% dos respondentes, a natureza como um todo é o principal prejudicado pelo descarte incorreto de resíduos sólidos urbanos, e não apenas os humanos ou outros animais, indicando que menos da metade dos estudantes possuía uma visão clara da gravidade desse problema. Por fim, 54% dos estudantes afirmaram que a lixeira era o destino final de seu lixo domiciliar, revelando ausência do hábito de separação desse material para coleta seletiva. Os resultados indicaram que houve ampliação do aprendizado sobre conceitos interdisciplinares de ciências (biologia e química) mediados a partir do espaço educacional não formal adotado.
Microbial contamination in the ethanol and cachaça fermentation process: impacts and applications
Authors: OLIVEIRA Amanda Cristina Dias de , OLIVEIRA Carlos Augusto Fernandes de , KAMIMURA Eliana Setsuko
Published: July 2023

Brazil is a major powerhouse in the production of sugarcane. Consequently, several supply chains use it as a raw material, such as the food sector, mainly in the production of sugar and beverages, such as cachaça, and the biofuels sector, with the production of ethanol, an important product for the Brazilian economy. The production of cachaça and ethanol share an important stage known as fermentation, a fundamental process that defines the quality and yield of the alcoholic fermentation product, which is achieved using Saccharomyces cerevisiae. Different industrial strains have been selected to promote alcoholic fermentation efficiently and with high productivity. However, it is possible that microorganisms from various stages of the production chain reach the fermentation phase, compromising it. Contaminants can vary from different genera of yeasts, including Dekkera and Pichia, to bacteria, mainly belonging to the Lactobacillaceae family, which produce lactic acid. Contaminating microorganisms affect the fermentation stage and, as a consequence, the quality of the produced cachaça or the production efficiency of ethanol. Recent studies have shown that these contaminants, in addition to resulting in negative aspects of sugarcane fermentation, can also present interesting physiological characteristics that can be applied in bioprocesses in other productive sectors or to improve fermentation strains.
Sumber Modal Insan dan Amalan Inovasi Terbuka terhadap Pengkomersialan Penyelidikan di Universiti Awam Malaysia
Authors: Muhammad Razaki Marina , Ismail Mohammad , Mohamad Anuar Nur Izzati
Published: July 2023

Pengkomersialan penyelidikan merupakan salah satu penyumbang kepada pertumbuhan ekonomi negara. Kerajaan Malaysia telah mewujudkan pelbagai kemudahan dan persekitaran bagi menggalakkan pengkomersialan di negara ini. Namun begitu, kadar pengkomersialan hasil penyelidikan di Malaysia masih rendah dan kurang memuaskan. Oleh yang demikian, kajian ini bertujuan untuk mengenal pasti hubungan antara sumber modal insan, amalan inovasi terbuka dan pengkomersialan penyelidikan serta kesan amalan inovasi terbuka sebagai pengantara antara sumber modal insan dan pengkomersialan penyelidikan. Data dikumpulkan melalui tinjauan soal selidik dan menggunakan pendekatan persampelan rawak mudah. Seramai 155 ahli akademik telah melengkapkan tinjauan tersebut. Perisian SmartPLS 3 digunakan untuk menguji hipotesis kajian menggunakan pemodelan persamaan berstruktur. Hasil analisis menunjukkan bahawa amalan inovasi terbuka adalah signifikan terhadap pengkomersialan penyelidikan dan berperanan sebagai pengantara antara sumber modal insan dan pengkomersialan penyelidikan. Namun demikian, sumber modal insan tidak mempunyai hubungan yang signifikan dengan pengkomersialan penyelidikan. Secara keseluruhannya, dapatan kajian membuktikan bahawa sumber modal insan mempunyai hubungan dengan pengkomersialan penyelidikan melalui amalan inovasi terbuka sebagai pengantara. Ini menunjukkan bahawa sumber modal insan sahaja tidak cukup untuk hasil penyelidikan dapat dikomersialkan tetapi memerlukan amalan inovasi terbuka.
Research commercialization is one of the contributors to the country's economic growth. The Malaysian government has created various facilities and environments to encourage commercialization in the country. However, the rate of commercialization of research results in Malaysia is still low and unsatisfactory. Therefore, this study aims to identify the relationship between human capital resources, open innovation practices and the commercialization of research as well as the effect of open innovation practices as a mediator between human capital resources and the commercialization of research. Data was collected through a questionnaire survey and using a simple random sampling approach. A total of 155 academics completed the survey. Smart PLS3 software was used to test the research hypotheses using structural equation modelling. The results of the analysis show that open innovation practices are significant to the commercialization of research and acts as a mediator between human capital resources and the commercialization of research. However, human capital resources do not have a significant relationship with the research commercialization. Overall, the findings of the study prove that human capital resources have a relationship with the commercialization of research through open innovation practices as mediators. This shows that human capital resources alone are not enough for research results to be commercialized but require open innovation practices.
A Review of Physical Safety for Individual with Autism Spectrum Disorder
Authors: Zeng Shulan , Xiu Yunhui , Tang Shiyuan
Published: July 2023

Physical safety for individual with Autism Spectrum Disorder plays an important role in improving the quality of life for the group. According to the exist available information, there are some guidelines for construction of safe school and home environment for the group, but it’s necessary to deepen further research to customize these criteria. There is a little research about the community safety and transition for Autism Spectrum Disorder, which is needed to enrich relative research, and it is a critical measure to facilitate the quality of life for the family whose member diagnosed as Autism Spectrum Disorder.
The Advantages of Ideological and Political Education of Middle School Physics and The Matters Needing Attention in Its Implementation
Authors: Gong Yanxiang , Wu Xiaomei , Ma Chuantao , Guo Juan
Published: July 2023

Physics is one of the compulsory natural science courses in middle school. There are many abstract concepts and formulas in physics curriculum, which requires students to have certain logical thinking, physical image imagination ability, problem analysis ability, etc. These require students to have strong learning ability. The ideological and political education of curriculum is a new requirement of the current middle school education and teaching reform. The core problem of the construction of ideological and political education in physics teaching is to integrate ideological and political education into physics teaching so that the two can complement each other and promote each other. This paper analyzes the advantages of ideological and political education in middle school physics, and gives some precautions for the implementation of ideological and political education. It is suggested to cultivate students' ideological and moral character by virtue of the establishment of laws in physics, the scientific spirit and excellent character of physicists, so as to realize the unity of physics teaching and ideological and political education, and cultivate talents with comprehensive quality required by the times.
Distance Does Not Matter any Longer - India Emerges as a Leader in Telehealth
Authors:   Ph.D Scholar, Department of Finance and Management Sciences, M.S. Ramaiah University of Applied Science, Bangalore (Karnataka), India., M.R Dr. Roopashree , Ramakrishan Niranjan ,   CEO MyLab Connect, Chennai (Tamil Nadu), India.
Published: July 2023

Telehealth is the need of the hour for both healthcare providers & patients. This helps to be innovative with the newer concepts that can be fine-tuned with an Indian perspective. Teleconsultation provides a conjoint system for small, medium, and large-sized hospitals to manage the day-to-day activities and managerial strategies that can be included in multi-specialty telemedicine services rendered to collaborate with peripheral units. The study which is undertaken is cross-sectional, descriptive in nature, with observatory method, the structured data collected which is qualitative and quantitative data collected, which is taken while commissioning the project for telehealth in a hub and scope model for a large-sized hospital situated in a suburban rural area in India. These aspects are elaborated which prove insight into project commissioning, challenges, and limitations faced during the operations of telehealth centers, quality, training, and regulatory aspects of telehealth services in India. The aspects of Telemedicine/Telehealth, Affordability, Accessibility, Reliability, and Scope with the relevance of clinical importance, and role in non-communicable diseases are discussed. Remote patient monitoring (RMP) is also called the Store and Forward form of teleconsultation in which the patients upload images to come up with medical diagnoses are incorporated. Hub and scope model and Vendor analysis model have been depicted. The measurement model will provide the relevance of vendor analysis for commissioning the telemedicine projects. Telehealth technology helps to diagnose diseases by a remotely situated medical specialist who can evaluate the patients, situated at distance, with fluctuations and variations in medical conditions. These patients may be situated at home where the medications can be modified accordingly. With the help of telehealth technology, connecting digitally the remote, rural, and terrane areas; we can provide urban amenities in perspective health care services to the neediest humans in a holistic approach. The integration of healthcare that results in a continuum of care is vital. Real-time data for the effective management of staff and caregivers efficiently is enumerated.
A Quantum Chemical and Nonlinear Optical Investigation on L-Tryptophan Hydrochloride Single Crystals for Optoelectronic Device Applications
Authors: A Mohamed Ibrahim , S Arunachalam , J Suryakanth , M Velayutham Pillai
Published: July 2023

In this study, a semi-organic crystal of L-tryptophan hydrochloride (LTHC) has been synthesized and quality crystals has been grown using a slow evaporation technique. Singe crystal XRD confirms the monoclinic system with space group P21. UV optical studies displays the transmittance in the entire visible region. The Mulliken charge distribution and MEP mapping show significant charge transfer due to nucleophilic and electrophilic moieties. The molecule's chemical reactivity was examined using HOMO-LUMO and MESP investigations. The crystal's nonlinear properties were studied using the Kurtz-Perry method. These findings suggest that LTHC crystals may have potential applications in the field of nonlinear optics.
Implementasi Penilaian Kenaikan Jabatan Struktural Menggunakan Metode Smart (Simple Multi Attribute Retting Tech) Berbasis Android
Authors: Suherwin  , Yusuf Muhammad , Syamsuddin
Published: July 2023

Implementasi penilaian kenaikan jabatan struktural menggunakan metode Smart (simple multi attribute retting tech) berbasis android. Tujuan dari penelitian ini adalah untuk merancang sistem penunjang keputusan dalam penilaian Kinerja Pegawai untuk Kenaikan Jabatan Struktural dan untuk menerapkan metode Metode Simple Multi Attribute Retting Tech (SMART) terhadap sistem penunjang keputusan penilaian Kinerja Pegawai untuk Kenaikan Jabatan Struktural. Metode yang di gunakan adalah metode SMART, Metode SMART (Simple Multi Attribute Rating Technique) sebuah motode dikembangkan pada tahun 1997 oleh Edward. SMART  adalah metode  Pengambilan atau pengutipan Keputusan yang multi atribut untuk membantu stakeholder dalam memilih antara beberapa alternative, Pada penelitian iniUML(Unified Modeling Language), yang didesain secara terstruktur yang terdiri dari rancangan model usecase diagram, activity diagram, sequence diagram dan class diagram. Bahasa yang digunakan dalam membangun system ini adalah bahasa pemrograman PHP dengan Android. Hasil dari penelitian ini adalah aplikasi berbasis android untuk penginputan kelengkapan berkas serta aplikasi website untuk admin. Berdasarkan hasil Uji Coba dengan 3 alternatif dengan menggunakan metode SMART Hasil perangkingan tertinggi  yaitu alternative 2 dengan sebagai pegawai yang layak direkomendasikan kenaikan jabatan dengan perserntasi nilai akhir sebesar 78.828125. Maka dapat disimpulkan bahwa bobot sangatlah berpengaruh dalam perhitungan ini. Serta Aplikasi Android mudah digunakan dalam pennginputan kelengkapan berkas
Tinjauan Fikih Munakahat terhadap Pandangan Generasi Z mengenai Kafa'ah dalam Pernikahan
Authors: Agustine Hendra Karunia , Supriyadi Yadi
Published: July 2023

Kesetaraan dalam pernikahan adalah mewujudkan kemaslahatan kedua belah pihak antara suami istri yang berupa pergaulan yang berkelanjutan dengan di iringi rasa sayang dan dekat diantara keduanya. Terdapat konsep kafa’ah dalam pernikahan untuk memilih calon pasangan, diantaranya adalah calon pasangannya baik agamanya atau sholih-sholihah. Selain itu, kriteria lainnya adalah pekerjaan, finansial stabil. Pemahaman generasi Z sendiri memiki kriteria tersendiri dalam memilih pasangan. Faktanya saat ini ditemukan beberapa kriteria yang dipilih. Namun belum/kurang sesuai dengan norma yang diajarkan Islam. Akan tetapi Rasulullah Saw dalam anjurannya menekankan untuk memilih pasangan hidup berdasarkan kualitas keagamaanya. Penelitian ini bertujuan untuk mengetahui pandangan generasi Z terhadap kafa’ah dalam pernikahan di Desa Cilimus Kecamatan Cilimus Kabupaten Kuningan. Selain itu penelitian juga bertujuan untuk mengetahui pandangan generasi Z terhadap kafa’ah dalam pernikahan di tinjau dari perspektif fikih munakahat Desa Cilimus Kecamatan Cilimus Kabupaten Kuningan. Metode penelitian yang digunakan adalah metode kualitatif. Penelitian ini termasuk jenis penelitian lapangan atau flied research. Teknik pengumpulan data yang digunakan adalah wawancara dan dokumentasi. Sasaran dalam penelitian yang dilakukan penulis yaitu generasi Z masyarakat  Desa Cilimus Kecamatan Cilimus Kabupaten Kuningan. Adapun hasil penelitian. Pertama, pandangan generasi Z  terhadap kafa’ah dalam pernikahan Desa Cilimus Kecamatan Cilimus Kabupaten Kuningan adalah kesetaraan pada faktor agama, karena generasi Z memandang empat faktor penting dalam menikah yaitu agama, nasab, harta, dan pekerjaan, tetapi faktor agama menurut mereka lebih penting dari yang lainnya Kedua, pandangan generasi Z terhadap kafa’ah dalam pernikahan di tinjau dari perspektif fikih munakahat Desa Cilimus Kecamatan Cilimus Kabupaten Kuningan adalah masih sesuai dengan tuntunan agama, karena masih mempertimbangkan faktor agama sebagai faktor utama konsep kafa’ah dalam pernikahan.
Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report
Authors: Barbosa Yago Eloy Souza , Lopes Ana Camila Xavier , Chaves Camila Delfino , Conrado Régis Ponte , Costa Marcelo Leite Vieira , Leal Renato Mazon Lima Verde
Published: July 2023

Carcinosarcomas are endometrial neoplasms with malignant epithelial and mesenchymal components. These are rare tumors, corresponding to <5% of uterine cancers. The average age at diagnosis is 65 years and the most characteristic symptom is transvaginal bleeding, common to other uterine tumors. The definitive diagnosis of the lesion is done by analyzing the surgical specimen and the first-line treatment is surgery with adjuvant chemotherapy and radiotherapy. The authors report a case of a 59-year-old female diagnosed with a uterine carcinosarcoma, whose epithelial component underwent an epithelial-mesenchymal transition. The outstanding aspects of this report are the aggressiveness of this tumor and the presence of a lymph node metastasis by the sarcomatous component, which represents an unusual biological behavior.
Indicadores para un sistema de monitoreo de impactos del turismo mediante Límites de Cambio Aceptable en la laguna de Quilotoa, Reserva Ecológica Ilinizas
Authors: Torres Matovelle Pablo Aníbal
Published: July 2023

El monitoreo de los efectos de la actividad turística en los sitios de visita de las áreas protegidas constituye un aspecto fundamental para su manejo turístico. La presente investigación plantea los indicadores para un sistema de monitoreo de impacto turístico en la laguna de Quilotoa, uno de los principales sitios de visita de la Reserva Ecológica Ilinizas. Para realizar la investigación se adoptó el modelo de Límites de Cambio Aceptable, llevando adelante tres etapas del mismo: identificación de preocupaciones del área, definición de actividades y elección de indicadores, para lo cual fue pertinente aplicar técnicas de encuesta, entrevista, observación participante y taller. Los indicadores de impacto planteados son: tipo de basura, número de grafitis, amplitud de grafitis, número de senderos alternativos, número de gradas visibles, número de miradores no autorizados, número de fogatas y porcentaje de insatisfacción del visitante
Survival Outcomes of Dogs with Appendicular Osteosarcoma Treated with Traditional Chinese Veterinary Medicine: Retrospective Analysis of 7 Cases
Authors: Kanemitsu Kaori
Published: July 2023

Canine appendicular osteosarcoma (OSA) is an aggressive, malignant bone tumor of the limbs with high metastatic potential. Even with surgery and chemotherapy, average survival is approximately 52 weeks (1 year) and with surgery only, survival shortens to 26 weeks (6 months). This retrospective case series reports the post-amputation survival outcomes of 8 dogs with appendicular OSA. Four dogs (4/8) were treated with a combination of conventional therapeutics (chemotherapy, nonsteroidal anti-inflammatory drugs/NSAIDS) and traditional Chinese veterinary medicine (TCVM). The TCVM therapy was composed of various combinations of acupuncture, Chinese herbal medicine, food therapy and Tui-na. Three dogs (3/8) were treated with post-surgical TCVM without conventional therapy. One dog (1/8) received post-surgical chemotherapy (1 round) and NSAIDS. Among the 7 dogs receiving TCVM treatments, the median survival time was 114.4 weeks (ranging from 36.0 to 346.1 weeks). Patients who received conventional treatment and TCVM had greater median survival time (120 weeks) compared to those receiving TCVM treatment only (53 weeks). There were 6 (85.7%) TCVM-treated dogs that survived more than 1 year and 4 (57.1%) that lived more than 2 years after amputation. Based on Wilcoxon signed rank test, the median survival time of TCVM-treated subjects was significantly longer than the expected average survival of 52 weeks/1 year (p = 0.023). The NSAID/chemotherapy (1 round) treated dog survived 11 weeks. The study, while with limited cases, concluded that TCVM treatments might be beneficial to prolong the survival time in OSA dogs after amputation. Randomized controlled trials are warranted to confirm these observations.
Management of Equine Allergic Airway Disease: A Review of Conventional and Complementary Therapies
Authors: Eaton Sarah
Published: July 2023

Respiratory allergies in horses are a common health problem and can vary from mild discomfort easily managed with husbandry changes to severe, performance-limiting effects with animals unable to participate in their routine training programs. Classic allergies are primarily Type 1 hypersensitivity reactions, in which the body produces immunoglobulin E (IgE) against normally innocuous environmental molecules. Other changes seen with Type 1 reactions include T-cell dysregulation, hyper-reactive responses of various organs (usually lungs and skin), and changes in the secretion of various cell-to-cell mediators. Allergies are generally suspected via history and clinical signs, but advanced tools such as upper airway endoscopy or bronchioalveolar lavage may be needed for confirmation. The key to allergy treatment is environmental changes, but this takes time and may be impossible based on a horse’s lifestyle. Conventional medications to treat allergies have focused on anti-inflammatory and bronchodilator administration, which provide rapid relief, while the environment is modified if possible. Integrating traditional Chinese veterinary medicine (TCVM) provides an additional approach to medical treatment that may reduce the need and/or dose of conventional medications, particularly during long-term disease management. It offers a variety of modalities such as acupuncture, Chinese herbal medicine, and food therapy that can be targeted to patient need and temperament. Significant improvement in quality of life may be seen with the individualized patient management that integrating TCVM treatment provides. This paper reviews immune mediated mechanisms associated with allergic respiratory disease and explores both conventional and TCVM based treatment protocols used to treat affected horses.