bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial and Temporal Variation in the Antagonistic and Mutualistic Interactions among Seed Predator Arthropods, Seed-Dispersing Birds, and the Spanish Juniper
Authors: Mezquida Eduardo T. , Olano José Miguel
Published: August 2024

Plants interact with both antagonistic and mutualistic animals during reproduction, with the outcomes of these interactions significantly influencing plant reproductive success, population dynamics, and the evolution of plant traits. Here, we investigated the spatial and temporal variations in the interactions between Juniperus thurifera, its seed-dispersing birds, and three specific arthropod species that attack the fleshy cones during the predispersal period. We assessed how plant traits affect levels of cone damage by arthropods and seed dispersal by birds, the occurrence of competition among arthropod species, and the impact of seed predators on the activity of frugivores. Plant traits, cone damage by arthropods, and seed dispersal by birds showed spatiotemporal variability. Fluctuation in cone abundance was the leading factor determining damage by arthropods and bird dispersal with a secondary role of cone traits. Large crops satiated predispersal seed predators, although the amount of frugivory did not increase significantly, suggesting a potential satiation of bird dispersers. Crop size and cone traits at individual trees determined preferences by seed predator species and the foraging activity of bird dispersers. Competition among arthropods increased during years of low cone production, and seed predators sometimes negatively affected bird frugivory. High supra-annual variations in cone production appear to be a key evolutionary mechanism enhancing J. thurifera reproductive success. This strategy reduces the impact of specialized seed predators during years of high seed production, despite the potential drawback of satiating seed dispersers.
Identification and Functional Insights of Knickkopf Genes in the Larval Cuticle of Leptinotarsa decemlineata
Authors: Zeng Mu-Zi , Zhou Wei , Wen Shan-Shan , Wu Hao , Zhang Qing , Fu Kai-Yun , Guo Wen-Chao , Shi Ji-Feng
Published: August 2024

The Colorado potato beetle (Leptinotarsa decemlineata) is a major pest of potato crops. While Knickkopf (Knk) genes are essential for insect cuticle formation, their roles in pests like L. decemlineata remain unclear. This study aims to identify and characterize Knk genes in L. decemlineata and explore their functions in larval development and cuticle integrity. We used genomic and transcriptomic databases to identify LdKnk-family genes, validated through RT-PCR and RACE. Gene expression was analyzed at various developmental stages and tissues using qRT-PCR. RNA interference (RNAi) and Transmission electron microscopy (TEM) were applied to determine the functional roles of these genes. Four LdKnk-family genes were identified. Spatio-temporal expression analysis indicated significant gene expression during larval molting and pupal stages, especially in the epidermis. RNAi experiments showed that silencing LdKnk and LdKnk3-5′ led to reduced larval weight, cuticle thinning, and increased mortality, while LdKnk3-FL knockdown caused abnormal cuticle thickening and molting disruptions. LdKnk2 knockdown increased epicuticle and endocuticle thickness without visible phenotypic changes. The study highlights the essential roles of LdKnk-family genes in maintaining cuticle structure and integrity, suggesting their potential as targets for RNAi-based pest control.
Examination of Vitreolenticular Interface in Relation to Different Phacoemulsification Parameters in Early and Late Postoperative Period
Authors: Elekes Ágnes , Vámosi Péter
Published: August 2024

Background: The surgical parameters of phacoemulsification can significantly impact the behavior of the anterior hyaloid membrane (AHM). Methods: In this prospective study, anterior segment optical coherence tomography was used to examine the attachment or detachment of the AHM of 82 eyes after uneventful phacoemulsification preoperatively and postoperatively over 1 year. The impacts of the capsulorhexis’ size, number of hydrodissections, nuclear sclerosis grade, cumulative dissipated energy (CDE), ultrasonic time, total surgical time, weakness of zonular fibers, presence of lens materials in Berger’s space (LM-BS), and fluid usage were investigated in relation to the behavior of the AHM. Results: A significant linear trend regarding anterior vitreous detachment (AVD) was observed in the presence of zonular weakness and high CDE at all postoperative times (p ≤ 0.024 and p ≤ 0.005, respectively). Similarly, AVD was observed at 1-month, 3-month, and 1-year follow-ups in cases of high nuclear sclerosis grades (p ≤ 0.044) and high fluid usage (p ≤ 0.021). A significant correlation was observed in the group of LM-BS as the zonular weakness value increased (OR: 0.085; 95% CI: 0.017 to 0.420; p = 0.002), and the fluid usage was also significantly higher (OR: 1.049; 95% CI: 1.003–1.096; p = 0.037). Conclusions: Zonular weakness, high CDE, a hard nucleus, and high fluid usage are risk factors for postoperative AVD.
Effectiveness and Safety of Etanercept in Paediatric Patients with Plaque-Type Psoriasis: Real-World Evidence
Authors: Narbutt Joanna , Jakubczak Zofia , Wasiewicz-Ciach Paulina , Wojtania Joanna , Krupa Katarzyna , Sobolewska-Sztychny Dorota , Ciążyńska Magdalena , Kołt-Kamińska Marta , Reich Adam , Skibińska Małgorzata , Lesiak Aleksandra
Published: August 2024

Background: Psoriasis is a chronic, multisystemic, inflammatory disease affecting approximately 1% of children and significantly reducing their health-related quality of life. Etanercept is a biologic fusion protein-blocking TNF-α and belongs to one of the biologics used among the children population. The purpose of this study was to assess the effectiveness and safety profile of etanercept in paediatric patients with plaque-type psoriasis. Material and methods: The outcome of the treatment was evaluated based on Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), and Children’s Dermatology Life Quality Index (CDLQI). Achievement of at least PASI75 at week 16 was assessed as an adequate response to therapy, which was the primary endpoint. Results: Forty-three paediatric patients were included in the study, 24 females and 19 males. The average age at inclusion into our study was 13 years. At baseline, the mean PASI score, BSA, and CDLQI were 16.3 ± 6.5, 22.3 ± 12.2%, and 17.4 ± 5.3, respectively. At week 16, 90.7% of patients achieved PASI 50, 79.1% achieved PASI 75, and 46.5% attained PASI 90. There was also a decrease in mean BSA and CDLQI values to 3.5 ± 3.8 and 5.4 ± 5.7, respectively. Conclusions: Etanercept proved to be effective, safe, and well-tolerated among the paediatric population with psoriasis.
Quantitative Approach to Quality Review of Prenatal Ultrasound Examinations: Fetal Biometry
Authors: Combs C. Andrew , Amara Sushma , Kline Carolyn , Ashimi Balogun Olaide , Bowman Zachary S.
Published: August 2024

Background/Objectives: To evaluate the quality of an ultrasound practice, both large-scale and focused audits are recommended by professional organizations, but such audits can be time-consuming, inefficient, and expensive. Our objective was to develop a time-efficient, quantitative, objective, large-scale method to evaluate fetal biometry measurements for an entire practice, combined with a process for focused image review for personnel whose measurements are outliers. Methods: Ultrasound exam data for a full year are exported from commercial ultrasound reporting software to a statistical package. Fetal biometry measurements are converted to z-scores to standardize across gestational ages. For a large-scale audit, sonographer mean z-scores are compared using analysis of variance (ANOVA) with Scheffe multiple comparisons test. A focused image review is performed on a random sample of exams for sonographers whose mean z-scores differ significantly from the practice mean. A similar large-scale audit is performed, comparing physician mean z-scores. Results: Using fetal abdominal circumference measurements as an example, significant differences between sonographer mean z-scores are readily identified by the ANOVA and Scheffe test. A method is described for the blinded image audit of sonographers with outlier mean z-scores. Examples are also given for the identification and interpretation of several types of systematic errors that are unlikely to be detectable by image review, including z-scores with large or small standard deviations and physicians with outlier mean z-scores. Conclusions: The large-scale quantitative analysis provides an overview of the biometry measurements of all the sonographers and physicians in a practice, so that image audits can be focused on those whose measurements are outliers. The analysis takes little time to perform after initial development and avoids the time, complexity, and expense of auditing providers whose measurements fall within the expected range. We encourage commercial software developers to include tools in their ultrasound reporting software to facilitate such quantitative reviews.
Low Diagnostic Accuracy of Transthoracic Ultrasound for the Assessment of Spontaneous Pneumothorax in the Emergency Setting: A Multicentric Study
Authors: Quarato Carla Maria Irene , Mirijello Antonio , Bocchino Marialuisa , Feragalli Beatrice , Lacedonia Donato , Rea Gaetano , Lieto Roberta , Maggi Michele , Hoxhallari Anela , Scioscia Giulia , Vicario Aldo , Pellegrino Giuseppe , Pazienza Luca , Villani Rosanna , Bellanova Salvatore , Bracciale Pierluigi , Notarangelo Stefano , Morlino Paride , De Cosmo Salvatore , Sperandeo Marco
Published: August 2024

Background: Pneumothorax (PNX) represents a common clinical condition in emergency departments (EDs), requiring prompt recognition and treatment. The role of transthoracic ultrasounds (TUSs) in the diagnosis of PNX is still debated. We aimed to prospectively evaluate the accuracy of TUSs in the detection of spontaneous PNX in EDs. Methods: A total of 637 consecutive adult patients who presented to the EDs of four Italian hospitals complaining of acutely onset chest pain and dyspnoea were included in the study. Exclusion criteria were previous traumatic events, cardiogenic causes of pain/dyspnoea and suspected tension PNX. The absence of “lung sliding” (B-mode) and the “bar-code” sign (M-mode) were considered indicative of PNX in a TUS. Accuracy, sensitivity, specificity, and positive and negative predictive values (PPVs, NPVs) were calculated using a chest CT scan as reference. Results: Spontaneous PNX occurred in 93 patients: of those, 83 (89.2%) were correctly identified by TUSs. However, 306 patients with suspected PNX at TUS were not confirmed by chest CTs. The diagnostic accuracy of both the absence of “lung sliding” and “bar-code” sign during TUS was 50.4% (95% CI: 46.4–54.3), sensitivity was 89.2% (95% CI: 81.1–94.7), specificity was 43.8% (95% CI: 39.5–48.0), the PPV was 21.3% (95% CI: 19.7–23.1) and the NPV was 96.0% (95% CI: 92.9–97.7). Conclusions: TUS showed high sensitivity but low specificity in the identification of PNX in EDs. Relying exclusively on TUSs results for patients’ management in ED settings is neither suitable nor recommendable. TUS examination can be useful to strengthen the clinical suspicion of PNX, but its results should be confirmed by a chest X-ray or CT scan.
Humeral Head Preservation after Neglected Glenohumeral Dislocation by Latarjet and Infraspinatus Remplissage—A Case Report
Authors: van Gerven Pieter , Buijs Nikki , Blaas Leanne , Yuan J. Zhang , de Priester Jacobus A. , Derksen Robert Jan
Published: August 2024

Background: Neglected anterior glenohumeral dislocations provide a challenging problem for physicians. For many patients with these injuries, reverse shoulder arthroplasty has been the treatment of choice, although the preservation of the patient’s own humeral head might have significant advantages. Methods: We present a case of a 66-year-old male with a neglected anterior glenohumeral dislocation that he sustained 6 weeks prior when he was hit by a car as a pedestrian. Radiographic imaging revealed a large off-track Hill-Sachs deformity and a fracture of the greater tuberosity in addition to the persisting glenohumeral dislocation. We performed open reduction and to aid stability, an infraspinatus tendon remplissage and a Latarjet procedure were performed. Results: Apart from minor and self-limiting neuropraxia, recovery was without complications. At 24 month follow-up, the patient had no impairment in general activities, had no residual pain, and had a good active range of motion. Conclusions: The authors, therefore, believe that a combination of infraspinatus tendon remplissage and the Latarjet procedure seems a feasible alternative for reverse shoulder arthroplasty and can preserve the patient’s own humeral head.
Parents in the Driver’s Seat—Experiences of Parent-Delivered Baby-mCIMT Coached Remotely
Authors: Svensson Katarina , Eliasson Ann-Christin , Sundelin Heléne , Holmqvist Kajsa Lidström
Published: August 2024

Background/Objectives: Recent guidelines on early intervention in children at high risk of cerebral palsy (CP) recommend parental involvement and family-centered home-based interventions with parents as primary trainers. Therapist coaching by home visitation is resource demanding, and telerehabilitation is a viable option for remote intervention and coaching. This study aims to describe parents’ experiences of engaging in Baby-mCIMT coached remotely. Their infants are at high risk of unilateral cerebral palsy and the parents have been the primary trainers in regard to home-based intervention, optimizing the use of the affected hand. Methods: A qualitative approach involving semi-structured interviews with eight parents was employed. Data were analyzed using qualitative content analysis. Results: The overarching theme “Parents in the driver’s seat—learning through remote coaching to create conditions to enhance the child’s motor skills” describes parents’ experiences as primary training providers. The following three underlying categories with subcategories were identified: (1) Baby-mCIMT coached remotely in an everyday context—practical and technical prerequisites; (2) the child’s response and the therapists’ coaching supports active parental learning; (3) capability and sense of control—strengthening and demanding aspects. Conclusions: Our findings revealed that Baby-mCIMT coached remotely empowered the parents as primary trainers, which provided them with opportunities for understanding and learning about their child and their development. The findings underscore the importance of responsive professional guidance and a strong therapist–parent relationship to succeed with the Baby-mCIMT program coached remotely and to manage the digital coaching format.
The Respiratory Adjusted Shock Index at Admission Is a Valuable Predictor of In-Hospital Outcomes for Elderly Emergency Patients with Medical Diseases at a Japanese Community General Hospital
Authors: Hori Taiki , Aihara Ken-ichi , Watanabe Takeshi , Inaba Kaori , Inaba Keisuke , Kaneko Yousuke , Kawata Saki , Kawahito Keisuke , Kita Hiroki , Shimizu Kazuma , Hosoki Minae , Mori Kensuke , Kageji Teruyoshi , Uraoka Hideyuki , Nakamura Shingen
Published: August 2024

Background: The respiratory adjusted shock index (RASI) is a risk score whose usefulness in patients with sepsis and trauma has previously been reported. However, its relevance in elderly emergency patients with medical diseases is yet to be clarified. This study assessed the usefulness of the RASI, which can be evaluated without requiring special equipment, to provide objective and rapid emergency responses. Methods: In this retrospective study, we recruited patients with medical diseases, aged 65 years or older, who were transported to the emergency room from Tokushima Prefectural Kaifu Hospital and underwent arterial blood gas testing from 1 January 2022 to 31 December 2023. We investigated the association of the RASI with other indices, including the lactate level, National Early Warning Score 2 (NEWS2), Shock Index (SI), Sequential Organ Failure Assessment (SOFA) score, quick SOFA (qSOFA) score, and systemic inflammatory response syndrome (SIRS). Results: In this study, we included 260 patients (mean age, 86 years), of whom 234 were admitted to the hospital; 27 and 49 patients died within 7 and 30 days of admission, respectively. The RASI was positively correlated with the lactate level, NEWS2, SI, and increase in the SOFA score (p < 0.001). The RASI was higher in patients with a SIRS or qSOFA score ≥ 2 than in those without (p < 0.001). It predicted death within 7 and 30 days of admission with an area under the curve (AUC) of 0.80 (95% confidence interval [CI]: 0.73–0.87), sensitivity of 96.3%, and specificity of 53.6% when the cutoff value was set to 1.58 and with an AUC of 0.73 (95% CI: 0.66–0.81), sensitivity of 69.4%, and specificity of 70.6% when the cutoff value was set to 1.83, respectively. Conclusions: The RASI is a simple indicator that can be used for predicting in-hospital outcomes in elderly emergency patients with medical diseases. Larger prospective studies based on this study are needed.
Obstetric Outcomes in Women on Lithium: A Systematic Review and Meta-Analysis
Authors: Callovini Tommaso , Montanari Silvia , Bardi Francesca , Barbonetti Sara , Rossi Sara , Caso Romina , Mandracchia Giuseppe , Margoni Stella , Brugnami Andrea , Paolini Marco , Manfredi Giovanni , Giudice Luca Lo , Segatori Daniele , Zanzarri Andrea , Onori Luca , Calderoni Claudia , Benini Elisabetta , Marano Giuseppe , Massetti Marco , Fiaschè Federica , Di Segni Federica , Janiri Delfina , Simonetti Alessio , Moccia Lorenzo , Grisoni Flavia , Ruggiero Sara , Bartolucci Giovanni , Biscosi Marco , Ferrara Ottavia Marianna , Bernardi Evelina , Monacelli Leonardo , Giannico Alessandro Michele , De Berardis Domenico , Battisti Giulia , Ciliberto Michele , Brisi Caterina , Lisci Francesco Maria , D’Onofrio Antonio Maria , Restaino Antonio , Di Benedetto Luca , Anesini Maria Benedetta , Boggio Gianluca , Specogna Elettra , Crupi Arianna , De Chiara Emanuela , Caroppo Emanuele , Ieritano Valentina , Monti Laura , Chieffo Daniela Pia Rosaria , Rinaldi Lucio , Camardese Giovanni , Cuomo Ilaria , Brugnoli Roberto , Kotzalidis Georgios D. , Sani Gabriele , Mazza Marianna
Published: August 2024

Background/Objectives: Lithium taken during pregnancy was linked in the past with increased risk for foetal/newborn malformations, but clinicians believe that it is worse for newborn children not to treat the mothers’ underlying psychiatric illness. We set to review the available evidence of adverse foetal outcomes in women who received lithium treatment for some time during their pregnancy. Methods: We searched four databases and a register to seek papers reporting neonatal outcomes of women who took lithium during their pregnancy by using the appropriate terms. We adopted the PRISMA statement and used Delphi rounds among all the authors to assess eligibility and the Cochrane Risk-of-Bias tool to evaluate the RoB of the included studies. Results: We found 28 eligible studies, 10 of which met the criteria for inclusion in the meta-analysis. The studies regarded 1402 newborn babies and 2595 women exposed to lithium. Overall, the systematic review found slightly increased adverse pregnancy outcomes for women taking lithium for both the first trimester only and any time during pregnancy, while the meta-analysis found increased odds for cardiac or other malformations, preterm birth, and a large size for gestational age with lithium at any time during pregnancy. Conclusions: Women with BD planning a pregnancy should consider discontinuing lithium when euthymic; lithium use during the first trimester and at any time during pregnancy increases the odds for some adverse pregnancy outcomes. Once the pregnancy has started, there is no reason for discontinuing lithium; close foetal monitoring and regular blood lithium levels may obviate some disadvantages of lithium administration during pregnancy.
Prognostic Nomogram Predicting Survival and Propensity Score Matching with Demographics and Comparative Analysis of Prostate Small Cell and Large Cell Neuroendocrine Carcinoma
Authors: Ullah Asad , Yasinzai Abdul Qahar Khan , Lee Kue Tylor , Chaudhury Tristin , Chaudhury Hannah , Chandasir Abdullah , Wali Agha , Waheed Abdul , Tareen Bisma , Khan Marjan , Goyal Aman , Iqbal Asif , Sohail Amir Humza , Maan Soban , Sheikh Abu Baker , Ghafouri Sayed Ab Reshad , Khan Israr , Del Rivero Jaydira , Karki Nabin R.
Published: August 2024

Background: This retrospective study aims to examine the patient demographics, survival rates, and treatment methods for small-cell neuroendocrine carcinoma (SCNEC) and large-cell neuroendocrine carcinoma (LCNEC) of prostate origin while also identifying the main differences between common types of prostate cancer with comparative analysis for survival. Methods: Our analysis utilized the Surveillance, Epidemiology, and End Results database (SEER), and data was collected from 2000–2020. Cox proportional hazards and chi-squared analysis were used for statistical analysis. Results: A total of 718 cases of prostate small and large neuroendocrine carcinoma were identified. The median age was 71.5 years, and the median follow-up was 11.0 years (95% confidence interval (95% CI) = 9.2–12.8). Most patients were over the age of 80 years (33.8%) and Caucasian (74.4%). The overall 5-year survival was 8.0% (95% CI = 6.8–9.2). The 5-year OS for Caucasians was 7.3% (95% C.I. 6.0–8.3). For Black Americans, the 5-year OS was 11.9% (95% C.I. 7.3–16.5). For Hispanics, the 5-year OS was 12.2% (95% C.I. 7.7–16.7). The 5-year cause-specific survival (CSS) was 16.2% (95% CI = 14.3–18.1). For treatment modality, the five-year survival for each were as follows: chemotherapy, 3.5% (95% CI = 2.1–4.9); surgery, 18.2% (95% CI = 13.6–22.8); multimodality therapy (surgery and chemotherapy), 4.8% (95% CI = 1.7–7.9); and combination (chemoradiation with surgery), 5.0% (95% CI = 1.0–9.0). The prognostic nomogram created to predict patient survivability matched the findings from the statistical analysis with a statistical difference found in race, income, housing, stage, and nodal status. The nomogram also indicated a slight increase in mortality with tumors of greater size. This analysis showed a slight increase in mortality for patients of Asian race. In addition, there was a significant increase in death for patients with stage 3 tumors, as well as patients who underwent surgery and radiation. Furthermore, we performed propensity score matching for survival differences, and no survival difference was found between SCNEC and LCNEC. Conclusions: Asian patients, larger tumor size, and distant disease were associated with worse long-term clinical outcomes. By leveraging insights from registry-based studies, clinicians can better strategize treatment options, improving patient outcomes in this challenging oncology arena.
AMEsobreRuedas Early Powered Mobility in Children with Spinal Muscular Atrophy Type I: Protocol of a Randomized Controlled Trial
Authors: Palomo-Carrión Rocío , López-Muñoz Purificación , Longo Egmar , Romay-Barrero Helena , Ródenas-Martínez Maribel , Plasencia-Robledo María , de Andrés-Beltrán Beatriz , Coello-Villalón María , Díaz-López Cristina , Pacheco-da-Costa Soraya
Published: August 2024

Background: Young children with spinal muscular atrophy type 1 (SMA1) have limited independent mobility and participation that may lead to cognitive development delays. Implementing early powered mobility in interventions may help them to learn self-initiated movement, play, and having fun to participate in natural settings. The aim of this study is to evaluate the effectiveness of an early power mobility intervention for increasing participation, functional ability, and quality of life in young children with SMA1. Methods: AMEsobreRuedas is a randomized waiting list controlled clinical trial. A sample of 24 children (10 months-5 years old, with SMA1) will be randomly allocated to two groups. The experimental group will perform a family-centered intervention with powered mobility for 16 weeks in their natural environment: a 12-week-structured program three times a week; and a 4-week follow-up with free use of the powered mobility device. The control group (waiting list) will keep their routine and will receive the same intervention after the experimental group. Five assessments will be carried out at baseline and weeks 4, 8, 12, and 16. Primary outcomes are participation (YC-PEM); functional ability (PEDI-CAT); and quality of life (PedsQL-Neuromuscular module). Results: It is expected that this study will provide further knowledge about the positive impact of powered mobility for the analyzed variables. Moreover, family engagement in the intervention and establishment of functional goals may help to add valuable information about real needs in future research. Conclusions: Early powered mobility could increase the opportunities for children with SMA1 to learn to move independently and participate in their natural environment.
One Year Follow-Up of a 4-Year-Old Caucasian Girl Diagnosed with Stage IV Grade C Localized Periodontitis
Authors: Moga Radu-Andrei , Olteanu Cristian Doru
Published: August 2024

Stage IV grade C localized periodontitis (pre-puberal localized aggressive periodontitis/LPP), an extremely rare form of periodontal disease, occurs in otherwise healthy individuals (no signs of dental plaque/calculus) due a hyper-aggressive auto-immune response to high periodontopathic bacteria levels. Methods: A 4-year-old Caucasian girl with unusually high mobility of the deciduous lower left canine and localized gingival inflammation was misrecognized by multiple clinicians (initially diagnosed with hypophosphatasia, genetic and metabolic disorders, all turning negative), over a period of 4–6 months, despite initial radiographs showing clear pathognomonic signs. The LPP diagnostic was made by the last clinician, but by then the tooth was lost. Similar inflammation signs appeared around the lower deciduous right canine. X-ray examination showed similar bone and periodontal loss as previously seen, while periodontopathic bacteria tested highly positive. The patient received both mechanical cleaning and ten days of systemic antibiotic treatment (Augmentin and Metronidazole). Results: Two months later, inflammation signs disappeared, with periodontal regeneration radiologically present, and only small periodontopathic bacteria precursor concentrations. Conclusions: Despite initial periodontal loss, an adequate treatment can keep under control an LPP disease. Moreover, bone and periodontal regeneration appears if periodontopathic bacteria scores are kept lower, showing the importance of fast adequate diagnostic and treatment.
Current Role of PET CT in Staging and Management of Penile Cancers
Authors: Mirvald Cristian , Garaz Radion , Sinescu Ioanel , Preda Adrian , Labanaris Apostolos , Yossepowitch Ofer , Tsaur Igor , Surcel Cristian
Published: August 2024

Penile cancer (PeCa) is a rare urological malignancy characterized by significant geographical variations in both incidence and mortality rates. Due to its rarity and the consequent lack of randomized trials, current management is based on retrospective studies and small prospective trials. In addition, both the diagnostic pathways and treatment strategies exhibit substantial heterogeneity, differing significantly between less-developed and well-developed countries. The prognosis of PeCas is determined by the presence and extent of regional lymph node (LN) involvement. Therefore, the early detection and treatment of LN metastasis is paramount to ensure better outcomes. In recent decades, overall survival of PeCas has increased, mainly due to advancements in imaging techniques and risk stratification. We aim to provide an overview of the current role of PET CT imaging in the management of patients with PeCa.
Cognition in Patients with Spinocerebellar Ataxia 1 (SCA1) and 2 (SCA2): A Neurophysiological and Neuropsychological Approach
Authors: Colucci Fabiana , Stefanelli Sara , Contaldi Elena , Gozzi Andrea , Marchetti Alessia , Pugliatti Maura , Laudisi Michele , Antenucci Pietro , Capone Jay Guido , Gragnaniello Daniela , Sensi Mariachiara
Published: August 2024

Background/Objectives: Cognitive impairment in spinocerebellar ataxia patients has been reported since the early-disease stage. We aimed to assess cognitive differences in SCA1 and SCA2 patients. Methods: We performed neuropsychological (NPS) and neurophysiological (auditory event-related potentials, aERPs) assessments in 16 SCA1 and 18 SCA2 consecutive patients. Furthermore, clinical information (age at onset, disease duration, motor disability) was collected. Results: NPS tests yielded scores in the normal range in both groups but with lower scores in the Frontal Assessment Battery (p < 0.05) and Visual Analogue Test for Anosognosia for motor impairment (p < 0.05) in SCA1, and the Trail Making Test (p < 0.01), Raven’s progressive matrices (p < 0.01), Stroop (p < 0.05), and emotion attribution tests (p < 0.05) in SCA2. aERPs showed lower N100 amplitude (p < 0.01) and prolonged N200 latency (p < 0.01) in SCA1 compared with SCA2. Clinically, SCA2 had more severe motor disability than SCA1 in the Assessment and Rating of Ataxia Scale. Conclusions: SCA2 showed more significant difficulties in attentional, visuospatial, and emotional function, and greater motor impairment. In contrast, SCA1 showed less cognitive flexibility/phasic ability, probably affected by a more severe degree of dysarthria. The same group revealed less neural activity during nonconscious attentional processing (N100-N200 data), suggesting greater involvement of sensory pathways in discriminating auditory stimuli. NFS did not correlate with NPS findings, implying an independent relationship. However, the specific role of the cerebellum and cerebellar symptoms in NPS test results deserves more focus.
Combined Computed Coronary Tomography Angiography and Transcatheter Aortic Valve Implantation (TAVI) Planning Computed Tomography Reliably Detects Relevant Coronary Artery Disease Pre-TAVI
Authors: Felbel Dominik , Buck Christoph , Riedel Natalie , Paukovitsch Michael , Stephan Tilman , Krohn-Grimberghe Marvin , Mörike Johannes , Gonska Birgid , Panknin Christoph , Kloth Christopher , Beer Meinrad , Rottbauer Wolfgang , Buckert Dominik
Published: August 2024

Background: Before surgical or transcatheter aortic valve implantation (TAVI), coronary status evaluation is required. The role of combined computed coronary tomography angiography (cCTA) and TAVI planning CT in this context is not yet well elucidated. This study assessed whether relevant proximal coronary disease requiring coronary revascularization can be safely detected by combined cCTA and TAVI planning CT, including CT-derived fractional flow reserve (FFR) calculation in patients with severe aortic stenosis. Methods: This study analyzed patients with successful cCTA combined with TAVI planning CT using a 128-slice dual-source scanner. The detection via cCTA of relevant left main stem stenosis (>50%) or proximal coronary artery stenosis (>70%) was compared to invasive coronary angiography (ICA). Results: This study comprised 101 consecutive TAVI patients with a median age of 83 [77–86] years, a median STS score of 3.7 [2.4–6.1] and 54% of whom had known coronary artery disease. Of 15 patients with relevant coronary stenoses, 14 (93.3%) were detected with cCTA, while false positive results were found in 25 patients. Only in patients with previous percutaneous coronary stent implantation (PCI) were false positive rates (11/29) increased. In the subgroup without previous PCI, an improved classification performance of 87.5%, being mainly due to 11.1% false positive classifications, led to a negative predictive value of 98.5%. Conclusions: Combined cCTA and CT-FFR with TAVI planning CT via state-of-the-art scanners and protocols as a one-stop shop can replace routine ICA in patients prior to TAVI due to its safe detection of relevant coronary artery stenosis, although diagnostic performance of cCTA is only reduced in patients with coronary stents.
Prenatal Screening of Chromosomal Anomalies Using Genome-Wide or Target Cell-Free DNA: Preferences and Satisfaction of Pregnant Women
Authors: Ardiles-Ruesjas Victoria , Viñals Roser , Pauta Montse , Madrigal Irene , Borrell Antoni
Published: August 2024

Background/Objectives: Cell-free DNA (cfDNA) is a non-invasive prenatal test used to screen for common trisomies (target cfDNA) that can be expanded to assess all autosomal chromosomes (genome-wide cfDNA). As cfDNA testing gains popularity, it is crucial to examine the factors influencing the decision-making process of pregnant individuals when choosing between these two approaches. Methods: In this prospective cohort study, 190 individuals undergoing cfDNA testing for aneuploidy screening, according to the current screening protocol, were allowed to make their own choice between target and genome-wide cfDNA testing. They were asked to complete a first survey at 11–13 weeks, designed to explore their characteristics, preferences, and satisfaction with the prenatal genetic counseling session, as well as a Decisional Conflict Scale. A postnatal survey was administered three months after delivery, including the Decisional Regret Scale and two open questions. Results: 84% of participants opted for genome-wide cfDNA. However, 17% found the decision challenging, and 14% felt that the results might increase anxiety. No significant differences in participant characteristics were found when comparing decisions between genome-wide and target cfDNA. However, significant differences were observed regarding ethnicity (p = <0.001), educational level (p = 0.029), previous cfDNA experience (p = 0.004), and having sufficient information when comparing termination options (p = 0.002). After delivery, only 4% would have changed their decision. Conclusions: Individuals, regardless of their characteristics, prefer genome-wide cfDNA; however, the complexity of the results necessitates enhanced genetic education for prenatal care clinicians.
Resistin and In-Hospital Mortality in Patients with Acute Ischemic Stroke: A Prospective Study
Authors: Bârsan Ioana Cristina , Iluţ Silvina , Tohănean Nicoleta , Pop Raluca , Vesa Ştefan Cristian , Perju-Dumbravă Lăcrămioara
Published: August 2024

Background/Objectives: Understanding the prognostic factors of acute ischemic stroke (AIS) is essential for improving patient outcomes. The aim of this study was to establish the predictive role of plasmatic resistin and leptin on short-term mortality in adult patients with a first episode of AIS. Methods: This study enrolled 277 patients who were consecutively hospitalized for AIS. Demographic data, cardiovascular risk, comorbidities, and laboratory tests were collected. Death was noted if it occurred during hospitalization. Results: Death was recorded in 33 (11.9%) patients. Conducting multivariate analysis, the following variables were independent variables associated with in-hospital mortality: a resistin value of >11 ng/mL (OR 10.81 (95%CI 2.31;50.57), p = 0.002), a lesion volume of >18.8 mL (OR 4.87 (95%CI 1.87;12.67), p = 0.001), a NIHSS score of >7 (OR 5.88 (95%CI 2.01;17.16), p = 0.001), and the presence of IHD (OR 4.33 (95%CI 1.66;11.27), p = 0.003). This study has some limitations: single-center design (which may affect the generalizability of the results) and the potential impact of the COVID-19 pandemic on patient outcomes. Conclusions: This study demonstrated that resistin is a significant predictor of in-hospital mortality in AIS patients. Other established factors, such as a high NIHSS score, large lesion volume, and the presence of IHD, were reaffirmed as important predictors.
Psychological Aspects of Cutaneous Pain in Psoriasis
Authors: Kotewicz Magdalena , Krajewski Piotr K. , Jaworek Andrzej K. , Szepietowski Jacek C.
Published: August 2024

Introduction: Psoriasis is a chronic inflammatory disease that negatively impacts patients’ quality of life (QoL) and mental health. Itch and pain are prevalent symptoms of psoriasis and contribute to the psychosocial burden of this disease. This study aimed to evaluate the impact of skin pain on the prevalence and severity of symptoms of anxiety and depression and on the QoL in psoriasis patients. Methods: The studied population comprised 106 adults with psoriasis (34% female; mean age 42.1 ± 13.0 years). Disease severity was measured with the Psoriasis Area and Severity Index (PASI). The intensity of skin pain was assessed with the NRS and the Short Form McGill Pain Questionnaire (SF-MPQ). The Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) questionnaires were used to estimate the severity of depression and anxiety, respectively, as was the Hospital Anxiety and Depression Scale (HADS). Quality of life (QoL) was studied using the Dermatology Life Quality Index (DLQI). Results: Regarding anxiety assessment, females reported significantly higher scores with the HADS-A (8.42 ± 4.85 points vs. 5.14 ± 3.9 points; p < 0.001) and the GAD-7 compared to men (7.50 ± 5.58 points vs. 5.24 ± 4.79 points; p = 0.036). Similarly, the severity of depression was significantly higher in women, as measured with the PHQ-9 (7.50 ± 5.58 points vs. 5.24 ± 4.79 points, p = 0.021). Psoriasis patients with skin pain scored significantly higher in HADS Total score (p = 0.043), HADS-A (p = 0.022), PHQ-9 (p = 0.035), and DLQI (p < 0.001) than the rest of the studied group. The intensity of skin pain measured with the SF-MPQ correlated significantly with HADS Total score (p = 0.021), HADS-A (p < 0.001), HADS-D (p = 0.038), and PHQ-9 (p < 0.001). Additionally, there was a significant correlation between the intensity of cutaneous pain assessed using the VAS and the PHQ-9 (p = 0.022). Conclusions: Skin pain significantly influences the well-being of patients with psoriasis as well as the symptoms of anxiety and depression. In particular, women with psoriasis are at increased risk of developing anxiety and depression. Our findings underline the necessity for a multidisciplinary approach to the management of this dermatosis.
Changes in Macular Pigment Optical Density after Intravitreal Faricimab in Neovascular Age-Related Macular Degeneration: A Pilot Study
Authors: Cennamo Gilda , Rinaldi Michele , Chiosi Flavia , Costagliola Ciro
Published: August 2024

Background: This study aimed to evaluate the effects of faricimab intravitreal injections in patients with exudative age macular degeneration (nAMD) after the loading dose using spectral domain optical coherence tomography (SD-OCT) and macular pigment optical density (MPOD). Methods: In this observational prospective study, we enlisted a total of 12 consecutive eyes of 12 patients (six females, six males; mean age 70.47 ± 2.46 years) affected by nAMD who consecutively presented to the Eye Clinic of the University of Naples “Federico II” and Monaldi Hospital of Naples, from June 2023 to December 2023. All patients received four once-monthly intravitreal injections of faricimab (6 mg/0.05 mL) (loading phase). At baseline and 1 month after the fourth faricimab monthly injection, all patients underwent assessment of best correct visual acuity (BCVA) and ophthalmic examination, including slit-lamp biomicroscopy, intraocular pressure (IOP), fundus biomicroscopy, SD-OCT, and MPOD. Results: A total of 12 eyes of 12 patients (six women, six men; mean age 70.47 ± 2.46 years) were included in this study. A statistically significant raise in BCVA and MOPD parameters was shown between baseline and after the loading phase (p < 0.001). Conclusions: Intravitreal injections of faricimab led in the short term to a significant functional and MPOD improvement along with a decrease in central macular thickness (CMT) and thus appears to be an effective treatment option without relevant adverse effects. MOPD may be considered as a prognostic factor associated with a good visual prognosis after intravitreal injections treatment.
The Accuracy and Reliability of the Power Measurements of the TACX Neo 2T Smart Trainer and Its Agreement against the Garmin Vector 3 Pedals
Authors: Morais Jorge E. , Bragada José A. , Magalhães Pedro M. , Marinho Daniel A.
Published: August 2024

The power output in cycling is one of the most important factors for athletes and coaches. The cycling community has several commercial gears that can be used. One of the most used is the TACX Neo 2T (TN2T) smart trainer. The objective of this study was to investigate the metrological proprieties of the TN2T (accuracy and reliability), as well as its agreement with the Garmin Vector 3 (GV3) pedals at different power stages. The sample consisted of ten regional-level cyclists with a mean age of 45.6 ± 6.4 years, who regularly participated in regional and national competitions. Residual relative differences were found between the two devices. Both devices showed good reliability with coefficients of variation and intraclass correlation coefficients ranging from 0.03% to 0.15% and from 0.731 to 0.968, respectively. Independent samples t-test comparison between devices showed no significant differences in all power stages (p > 0.05). Bland–Altman plots showed that more than 80% of the plots were within the 95% confidence intervals in all power stages. The present data showed that there were non-significant differences between the two devices at power stages between 100 W and 270 W, with a strong agreement. Therefore, they can be used simultaneously.
Prospective Review of Magneto-Resistive Current Sensors with High Sensitivity and Wide Temperature Range
Authors: Yang Zicai , Jiang Yanfeng
Published: August 2024

Current sensors play a vital role in power systems, industrial production, smart devices and other fields, which can provide critical current information in the systems for the safety and efficiency managements. The development of magneto-resistive effect technology in recent years expedites the research process of the current sensors in industrial-level applications. In the review, starting with the development status of the current sensors, the physical mechanisms of the relevant magneto-resistive effects and their early applications as the current sensors are introduced. Several design methods of the magnetic sensors, as well as their merits and shortcomings, are summarized. The performance parameters of the magnetic sensors based on AMR, GMR, TMR and Hall effects are reviewed, including the front-end amplification circuits and conditioning circuits. The industrial applications of the current sensors in the fields of automobiles and photovoltaic inverters are enumerated. The criterions for the current sensors to be used in different scenarios are discussed. In the future, it is imperative to continue the research and development of novel current sensors in order to satisfy the increasingly stringent demands of the industrial developments, in terms of the performance, cost and reliability of the current sensors.
Comparative Study on the Performances of a Hinged Flap-Type Wave Energy Converter Considering Both Fixed and Floating Bases
Authors: Chen Mingsheng , Yun Qihao , Hallak Thiago S. , Zhou Hao , Zhang Kai , Yang Yi , Tao Tao , Liu Shi , Jiang Wei , Li Changjie
Published: August 2024

The dynamical modeling and power optimization of floating wind–wave platforms, especially in regard to configurations based on constrained floating multi-body systems, lack in-depth systematic investigation. In this study, a floating wind-flap platform consisting of a flap-type wave energy converter and a floating offshore wind turbine is solved in the frequency domain considering the mechanical and hydrodynamic couplings of floating multi-body geometries and a model that suits the constraints of the hinge connection, which can accurately calculate the frequency domain dynamic response of the flap-type WEC. The results are compared with bottom-fixed flap-type wave energy converters in the absence of coupling with a floating wind platform. Moreover, combined with traditional optimization methods of power take-off systems for wave energy conversion, an optimization method is developed to suit the requirements of floating wind-flap platform configurations. The results are drawn for a specific operation site in the South China Sea, whereas a sensitivity analysis of the parameters is performed. It is found that the floating wind-flap platform has better wave energy absorption performance in the low-frequency range than the bottom-fixed flap-type wave energy converter; the average power generation in the low-frequency range can increase by up to 150 kW, mainly due to constructive hydrodynamic interactions, though it significantly fluctuates from the sea waves’ frequency range to the high-frequency range. Based on spectral analysis, operational results are drawn for irregular sea states, and the expected power for both types of flap-type WECs is around 30 kW, which points to a similar wave energy absorption performance when comparing the bottom-fixed flap with the flap within the hybrid configuration.
Wave–Induced Soil Dynamics and Shear Failure Potential around a Sandbar
Authors: Chen Ning , Tong Linlong , Zhang Jisheng , Guo Yakun , Liu Bo , Zhou Zhipeng
Published: August 2024

Sandbars are commonly encountered in coastal environments, acting as natural protections during storm events. However, the sandbar response to waves and possible shear failure is poorly understood. In this research, a two–dimensional numerical model is settled to simulate the wave-induced sandbar soil dynamics and instability mechanism. The model, which is based upon the Reynolds-averaged Navier–Stokes (RANS) equations and Biot’s consolidation theory, is validated using available experiments. Parametric studies are then conducted to appraise the impact of the wave parameters and soil properties on soil dynamics. Results indicate that the vertical distribution of the maximum vertical effective stress in the sandbar is different from that in the flat seabed, which decreases rapidly along the soil depth and then increases gradually. The impact of soil permeability and saturation on the vertical effective stress distribution around the sandbar also differ from that in the flat seabed. Unlike the flat seabed, the vertical distribution of shear stress in the sandbar increases with an increasing wave period. The sandbar soil shear failure potential is discussed based upon the Mohr–Coulomb criterion. Results show that the range of shear failure around the sandbar is wider and the depth is deeper when the wave trough arrives.
Characteristics and Mechanisms of Spring Tidal Mixing and Sediment Transport in a Microtidal Funnel-Shaped Estuary
Authors: Lin Yitong , Liu Dezheng , Liang Mingen , Zhang Tao , Huang Enmao , Zhu Zhiyuan , Jia Liangwen
Published: August 2024

Information about estuarine mixing and its control of sediment transport is crucial to elucidating the dynamics and evolution of estuaries. Here, the microtidal and funnel-shaped Zhenhai Estuary, located in the southwestern Pearl River Delta of China, is used to investigate the characteristics and mechanisms of water mixing and sediment transport based on observations from three spring tides. The results reveal that the studied estuary remains well mixed during spring tides from 2013–2022 despite its microtidal regime. Tidal stirring, which is enhanced by tidal energy convergence and benefits from the funnel-shaped geometry and shallow bathymetry, favors vertical mixing, contributing to the formation of strong mixing in the estuary. Due to the well-mixed regime, sediment transport in the estuary is dominated by the advective term, followed by a moderate tidal pumping term and minor estuarine circulation term. Accordingly, sediments within the estuary tend to be transported landward owing to the regulation of the funnel-shaped geometry, and a gradual but slow infilling trend is predictable. This paper deepens our understanding of hydrodynamics and sediment transport in microtidal estuaries.