bluuebunny/crossref_metadata_2025 huggingface dataset:
Perspectives for next generation sequencing in patients with follicular lymphoma
Authors: Kunevich E. O. , Martynkevich I. S. , Mikhaleva M. A. , Bogdanov А. N. , Motyko E. V. , Kuvshinov A. Yu. , Sidorkevich S. V. , Voloshin S. V.
Published: December 2023

Aim. To study the prognostic significance of gene mutations and intracellular signaling pathways involved in lymphomagenesis in patients with follicular lymphoma using next generation sequencing (NGS).

Materials and methods. The prospective study included 26 patients with a median age of 51.5 years. Mutational screening was performed for cohort using custom NGS Panel of 118 genes. Gene set enrichment analysis (GSEA) was performed using Metascape. The data was analyzed in SPSS Statistics 26 and R 4.2.2.

Results. The highest mutation frequency was noted in the genes: KMT2C – 50 %, KMT2D – 50 %, CREBBP – 31 %, NOTCH2 – 31 %, GNAS – 23 %. Missense mutations occurred with a frequency of 84.3 %. ARID1A gene mutation is an unfavorable prognostic factor according to progressive-free (p = 0.014) and event-free (p = 0.029) survival analysis. Tumor mutation burden (TMB) was defined as the number of mutations per megabase (Mb) of the coding sequence, the median TMB was 5.0 (3.3–8.3) mutations/Mb. The TMB threshold of 6 mutations/Mb divided patients into groups with high (44 %) and low (56 %) TMB. In the high TMB group, 2-year event-free survival was 27.3 % (95 % confidence interval 6.0–61.0), which was significantly lower than in low TMB group – 72.7 % (95 % confidence interval 41.9–91.6; p = 0.037). The most enriched cellular pathways according to GSEA results were regulation of cell activation (–log10(q-value) = 6.357), chromatin remodeling (–log10(q-value) = 5.707), histone modification (–log10(q-value) = 4.569). We have also demonstrated other possibilities of GSEA using follicular lymphoma as an example.

Conclusion. TMB is a significant prognostic factor in patients with follicular lymphoma. We have shown that mutations in the MYC, CREBBP, EZH2, KMT2D genes lead to dysregulation in several intracellular processes, mediating complex molecular changes. The most enriched intracellular pathways in follicular lymphoma are those of chromatin remodeling, regulation of cell activation and histone modification.
Glucocorticosteroid-induced complications in patients with idiopathic thrombocytopenic purpura
Authors: Zakharov S. G. , Mitina T. A. , Zakharova A. V. , Vardanyan R. V. , Kataeva E. V. , Chernykh Yu. B. , Vysotskaya L. L. , Ivanitskiy L. V. , Kontievskiy I. N. , Madzyara O. P. , Zhuravlev O. R. , Gorgun N. V. , Kharasova Z. M.
Published: December 2023

Glucocorticosteroids (GCS) are the first-line treatment for idiopathic thrombocytopenic purpura (ITP). Despite their high efficacy in patients with newly diagnosed ITP, an adequate level of platelets remains after GCS withdrawal in only less than 20 % of patients. Additionally, GCS use is associated with an increased risk of different adverse reactions, including serious and life-threatening ones. Thrombopoietin receptor agonists represent a relatively new class of drugs for treating ITP as a second-line therapy. This paper reviews the risks of GCS pharmacotherapy, as well as the evidence supporting the use of thrombopoietin receptor agonists as both first-line and second-line treatment for patients with ITP.
Clinical case of giant extramedullar plasmacytoma in a patient with multiple myeloma
Authors: Safuanova G. Sh. , Mansurova Yu. R. , Latypova A. A. , Bagautdinova А. U. , Rozhenkova T. Yu. , Valiakhmetova Ch. Kh.
Published: December 2023

One possible manifestation of multiple myeloma may be extramedullary plasmacytoma, manifested by infiltration of plasma cells outside the bone marrow. In the debut of the disease, bone plasmacytomas are most often diagnosed, in contrast to extramedullary ones, which are rare. According to the literature, the presence of extramedullary plasmacytoma is an unfavorable factor characterized by an aggressive disease course, the absence of an antitumor response to standard therapy, and low overall survival rates. Therefore, the pathogenesis, clinic, diagnosis and treatment of this variant of the disease require additional study. This article presents a clinical case of an aggressive course of extensive extramedullary plasmacytoma in a patient with multiple myeloma with an assessment of various combination therapy regimens efficacy.
Combination of lymphoproliferative diseases and pregnancy
Authors: Chernyshova A. L. , Chernyakov A. A. , Popova N. O. , Kravchuk T. L. , Trushchuk Yu. M. , Dil’ O. S. , Krasil’nikov S. E. , Antipov V. A. , Shumeykina A. O.
Published: December 2023

The article presents an analysis of the current state of the problem of the combination of lymphoproliferative diseases associated with pregnancy. Analysis of literature sources has shown that despite the seemingly obvious unfavorable relationship between pregnancy and lymphoproliferative diseases, most studies demonstrate a favorable prognosis regarding the prognosis and outcome of this oncological pathology in combination with pregnancy. The Research Institute of Oncology of the Tomsk SRI has sufficient experience in the treatment of this pathology, including on the background of pregnancy. We have presented two clinical cases in which successful treatment of lymphoproliferative processes in pregnant women has been demonstrated.
Targeted therapy for advanced forms of systemic mastocytosis in real clinical practice
Authors: Shikhbabaeva D. I. , Vinogradova O. Yu. , Neverova A. L. , Pankrashkina M. M. , Chernikov M. V. , Detkina E. O. , Kobzev Yu. N. , Malakho S. G. , Ptushkin V. V.
Published: December 2023

Background. Mastocytosis is a heterogeneous group of diseases that are characterized by excessive proliferation and accumulation of clonal (neoplastic) mast cells in one or more organs. Advanced variants of systemic mastocytosis (aggressive systemic mastocytosis, systemic mastocytosis associated with hematological neoplasm, and mast cell leukemia) are characterized by infiltration of organs by mast cells, which leads to organs dysfunction. Such patients require a more active approach and the use of cytoreductive therapy. Available therapeutic options include imatinib, interferon-alpha, cladribine. Only one of the targeted drugs is registered in Russia – midostaurin. Midostaurin is a potent                    multikinase inhibitor that is active against KIT regardless of mutation status. Midostaurin has shown its effectiveness in clinical trials, however, we know that data from real clinical practice often differ from clinical studies due to the characteristics of patients (preserved comorbid status, stable disease parameters) traditionally included in clinical trials.

Aim. To evaluate the effectiveness and safety of midostaurin in patients with advanced variants of systemic mastocytosis in real clinical practice.

Materials and methods. This work analyzed 13 patients (7 (54 %) men and 6 (46 %) women) who received midostaurin therapy for systemic mastocytosis (aggressive systemic mastocytosis – 9 (69 %), systemic mastocytosis associated with a hematological neoplasm – 4 (31 %)). The median age of patients when the diagnosis was verified was 73 (61–87) years, the median age when midostaurin was prescribed was 74 (61–88) years. According to the International prognostic scoring system for mastocytosis (IPSM) based on clinical variables, patients are classified as follows groups: SM1 – 1 (8 %) patient, SM2 – 3 (23 %), SM3 – 8 (61 %), SM4 – 1 (8 %).

Results. As a result of therapy, clinical improvement was achieved in 10 (77 %) patients, and stabilization in 3 (23 %) patients. During midostaurin therapy, grade I–II adverse events were noted from the gastrointestinal tract: nausea in 5 patients (38 %), vomiting in 2 (15 %), diarrhea in 6 (46 %). Hematological toxicity of grade I–II was also observed: anemia in 6 (46 %) patients, thrombocytopenia in 5 (38 %) patients. The median overall survival in the group was not achieved. The 2-year overall survival rate was 75 %.

Conclusion. The study results suggest the potential efficacy and safety of midostaurin in patients with aggressive systemic mastocytosis and systemic mastocytosis associated with hematological malignancies.
Isatuximab in the treatment of refractory and relapsed multiple myeloma: literature review and case report
Authors: Ryabukhina Yu. E. , Zeynalova P. A. , Abbasbeyli F. M. , Timofeeva O. L. , Valiev T. T. , Kupryshina N. A. , Zhukov A. G.
Published: December 2023

Multiple myeloma is a malignant tumor characterized by the proliferation of clonal plasma cells and currently remains an incurable disease, despite advances in therapy. Resistance and development of double refractoriness represent a significant problem, worsening the prognosis. To overcome double refractoriness, new proteasome inhibitors carfilzomib and ixazomib, the 3rd generation immunomodulator pomalidomide and monoclonal antibodies daratumumab, elotuzumab and isatuximab are used. Based on randomized phase III ICARIA-MM and IKEMA studies results, which demonstrated, along with a manageable safety profile, advantages in increasing the antitumor response depth, the rate of achieving negative minimal residual disease status and survival in all subgroups of patients with refractory/relapsed multiple myeloma, isatuximab is used in IsaPd (isatuximab, pomalidomide, dexamethasone) and IsaKd (isatuximab, carfilzomib, dexamethasone) combination. This article discusses the clinical pharmacology of isatuximab. The results of studies demonstrating the effectiveness and safety of antitumor therapy regimens including isatuximab, which made it possible to use it in clinical practice, are presented. We present a case report of a patient with refractory/relapsed multiple myeloma who received 3 lines of antitumor treatment, including class 2 proteasome inhibitors, lenalidomide and the monoclonal antibody elotuzumab. After 3 cycles of IsaPd (8 injections of isatuximab), partial remission and pain relief were recorded. The achieved antitumor effect, along with the absence of significant adverse events, facilitated the continuation of therapy at recommended doses.
A magyar tölgy (Quercus conferta Kit.) infraspecifikus taxonjai II. A taxonok kritikai értékelése
Authors: Bartha Dénes
Published: December 2023

Legutóbbi vizsgálataim során a magyar tölgy helyes tudományos nevének tisztázá- sa után a szakirodalom alapján az infraspecifikus változatosságot vizsgálva 21 nomenklatúrai típust sikerült összegyűjtenem. Ezek egy része hibrid taxonokra vonatkozik, melyeket egy későbbi publikáció fog részletezni. Jelen munkában a faj alatti változatosságot leíró infraspecifikus taxonokból a protológusok és a terepi kutatások alapján 11 taxonómiai típust lehetett elfogadottá tenni. Mivel ezek a típusok nem elkülönült populációkban vagy önálló elterjedési területtel fordulnak elő, ezért forma rangon kerülnek tárgyalásra. A lombhullató tölgyek jelentős heterofilliája miatt a herbáriumi lapok csak nagyfokú körültekintéssel értékelhetők, szükséges lenne a jövőben ezeket egységes szempontok figyelembevételével gyűjteni. A taxonómiai bélyegek tanulmányozása szempontjából az idősebb egyedek rendes fényhajtásainak halmozott levelei alatt található két levél a legalkalmasabb.
BILL CLINTON’S PRESIDENCY (1993 – 2001): A HISTORIC ERA OF PROGRESS AND PROSPERITY. THE PHENOMENON OF US ECONOMIC GROWTH
Authors:   National Technical University of Ukraine Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Ukraine, Boyeva Svitlana
Published: December 2023

The analysis of the phenomenon of the US economic recovery in the period 1993–2001, during which the US economy maintained high rates of growth in all sectors, contributes to a better understanding of the whole range of problems related to the development and functioning of the modern economic system. It is an important prerequisite for the effectiveness of restructuring processes in the national economy and its reconstruction after the end of the full-scale war launched by the Russian Federation on February 24, 2022. The purpose of the article is to study, on the basis of a comprehensive analysis of the latest American sources, the characteristic features of the social and economic strategy of domestic policy, the main directions, dynamics and trends of the growth of the USA’s economic power during this period 1993 – 2001 in the context of the world economy. The methodology of the research is based on the critical analysis of the latest American primary and secondary historical sources and scientific literature, on the application of civilizational, problem-chronological, systemic, regional, interdisciplinary approach to the knowledge of the evolution of economic history. The fundamental principles of the article are the principle of historicism, objectivity, scientificіty, unity of positive and normative aspects of science. For scientific comprehension of the problem, comparative, systemic-synergistic, historical-genetic, comparative-statistical methods. The novelty of the research consists in the consideration of the problem in a historical retrospective, theoretical understanding of the fundamental principles of the functioning and development of the US economy as a leading state in the post-bipolar world, the evolution of its theoretical systems in the specified period in the context of globalization processes of the modern world, interrelations and trends in the development of the general civilization process. The research has revealed that at the turn of the two millennia, the United States turned into a leading country in the world, its economic power reached its highest level. The author analyzes the main factors that contributed to this: high level of scientific and technical potential; favorable foreign policy conditions; intensive inclusion of the USA in the world integration processes, strengthening the processes of globalization and internetization of the American economy, its focus on high technologies and higher competitiveness in the world, provision of leading positions in the institutes of world and regional, international economic cooperation and reformation of the system of management.
US POLICY TOWARDS UKRAINE: BETWEEN LIBERAL-DEMOCRATIC VALUES AND PRAGMATIC INTERESTS
Authors:   The Institute of history of Ukraine The National Academy of Science of Ukraine, Kyiv, Ukraine, Martynov Andrei
Published: December 2023

The author analyzed in detail the main factors that influence the US policy towards Ukraine: 1) the relative importance of the internal and external priorities of the US, 2) the relative commitment to the policy of a united free Europe, 3) the relative importance of the policy towards Ukraine against other foreign policy priorities, 4) perceived complementarity Kyiv’s behavior with US interests and goals, 5) perceived coherence of Moscow’s behavior with US interests and goals, 6) relevant views of key figures in the executive branch of government and their relative influence, 7) pressure and restrictions from Congress, 8) pressure from Ukrainian organizations diaspora. In the first chapter of the monograph, the author addressed the period of R. Reagan’s presidency, when American policy towards the USSR consolidated liberal-democratic values and pragmatic interests. The second chapter examines in detail the vicissitudes of recognition of the independence of Ukraine by the United States. The third chapter of the monograph examines the role of the USA in the process of nuclear disarmament of Ukraine. The fourth chapter of the monograph is devoted to the US position regarding the Orange Revolution in Ukraine. In the fifth chapter, the author analyzed the reasons for the US’s refusal to provide assistance to Ukraine with lethal weapons.
Contribution of australia as the u.s. major non-NATO ally in helping Ukraine resist russian military aggression in 2014 – 2023
Authors:   State Institution «Institute of World History of the National Academy of Sciences of Ukraine»,  Kyiv, Ukraine, Zernetska Olga , Myronchuk Elena ,   State Institution «Institute of World History of the National Academy of Sciences of Ukraine»,  Kyiv, Ukraine
Published: December 2023

The article examines and analyzes the main types and means of assistance from Australia to Ukraine in its fight against Russian aggression. It outlines Australia’s priorities in the field of international security and its responses to Russia’s military expansion against Ukraine. The methodological basis of the article is based on the principles of systematic research of the modern history of international relations. Historical-genetic, comparative, and descriptive methods, as well as methods of critical analysis of sources and comparative analysis are used. The scientific novelty of the study consists of conducting a comprehensive analysis of Australia’s contribution to the resistance to Russian military aggression and monitoring trends in the development of relations between Australia and NATO states under the crisis conditions of modern geopolitical realities. Conclusions. The government of Australia considers the Russo-Ukrainian war as having significance beyond European security, taking on global importance. It declares its support and practically implements comprehensive and wide-ranging assistance to Ukraine. Among the main directions of this support are political and humanitarian measures, as well as the consolidation of international support through the establishment of sustainable cooperation with partners in areas related to ensuring national security and defense, and protecting the sovereignty and territorial integrity of Ukraine. Australia, alongside its American and European partners, demonstrated its ability to contribute to the formation of international support against Russian aggression. In particular, it provided substantial military assistance to Ukraine. This is the most significant contribution from the countries of the Indo-Pacific region to Ukraine’s security.
THE JIMMY CARTER ADMINISTRATION’SPOLICY TOWARDS THE ARAB-ISRAELI CONFLICT, 1977–1981
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Kyiv, Ukraine, Buzan Vitalii
Published: December 2023

The purpose of the article is to consider the U.S. policymaking towards the Arab-Israeli conflict, the Middle East process and the Palestinian problem under the presidency of Jimmy Carter. The research methodology is based on the principle of historicism and standards of objectivity. The author uses historical-comparative, problem-chronological, historical-genetic, and historical-systemic methods of historical research. The scientific originality. Special attention is paid to the U.S. policymaking towards the Arab-Israeli conflict and the intellectual basis of Carter’s Middle East policy. The author analyses the views of American high-ranking officials, leading experts, and policymakers regarding the concept of Arab-Israeli settlement and Soviet involvement in the Middle East peace process. The author outlines the role of the Soviet factor in American diplomatic calculations and considerations regarding the Arab-Israeli conflict. Conclusions. Initially, President Carter’s administration abandoned the concept of a step-by-step approach, partial settlement, and interim agreements. Instead, President Carter was determined to achieve a comprehensive peace settlement of the Arab-Israeli conflict, revived the idea of cooperation between Superpowers in the Middle East peace process, and agreed to reconvene the Geneva Conference on Middle East peace. The USA and the USSR were co-chairmen of the Geneva conference and issued a joint communiqué on the principles of a Middle East settlement. Among U.S. policymakers were opponents and supporters of Soviet participation in the peace process. Sadat’s peace initiative was a turning point in the U.S. strategy in the Middle East. After that, the USA changed its approach to the Middle East peace settlement, abandoned the idea of reconvening the Geneva Conference, and endorsed separate Egyptian-Israeli negotiations. President Carter’s administration was convinced that a peaceful solution to the Palestinian problem was essential to Middle East settlement. The U.S. officials began to mention the legitimate rights of the Palestinians and their self-determination. American policymakers elaborated an interim solution to the problem of a Palestinian homeland. In particular, they proposed the concept of a transitional arrangement for the West Bank and Gaza Strip.
The Effect of Fermentation Time on the Physicochemical and Microbiological Qualities of Buffalo Colostrum Kefir
Authors: Rizqiati Heni , Nurwantoro Nurwantoro , Prayitno Edi , Muttaqin Izza Wildani , Pangestu Ridho
Published: December 2023

This research aims to determine the best fermentation time to produce optimal buffalo colostrum kefir. Different fermentation times at 12, 24, 36, and 48 hours were used to measure the physicochemical and microbiological characteristics of buffalo colostrum kefir. To produce buffalo colostrum kefir, fermentation process at room temperature (27˚C±1) was used. Viscosity was measured using Ostwald viscometer and Total Dissolved Solid (TDS) was measured digital refractometer. Titratable acidity was analyzed using titration method and pH value was measured using pH meter. Protein content was analyzed using Kjeldahl method and fat content was analyzed using Soxhlet method. The result shows no significant differences (P>0.05) in viscosity which results in a value of 0.92±0.09 to 0.80±0.04 cP. Meanwhile, it shows significant differences (P<0.05) on TDS (24.02±0.80 to 13.30±0.76 ºBrix), titrable acid (1.96±0.10 to 2.53±0.04%), pH value (3.95±0.03 to 3.37±0.04), protein content (14.41±0.94 to 10.57±0.68%), fat content (20.33±0.88 to 6.89±0.90%), total LAB (2.85x106 to 9.57x106 CFU/ml), total yeast (2.16x105 to 7.76x105 CFU/ml), and total microbes (5.15x106 to 5.21x106 CFU/ml). The best treatment was 36 hours of fermentation with 20% grain concentration (w/v) because it produced the highest total Lactic Acid Bacteria (LAB), total yeast, and total microbes so it is potential to be a probiotic drink.
Characterization of Layer-by-Layer Biodegradable Films Based on Hydroxypropyl Methylcellulose-Nanochitosan
Authors: Muna Aulal , Wicaksono Rumpoko , Wibowo Condro
Published: December 2023

This research investigates the physical and optical properties of single-layer and layer-by-layer biodegradable films composed of hydroxypropyl methylcellulose (HPMC) and nanochitosan. Initially, HPMC and nanochitosan were formulated as single layers at various concentrations, and subsequently, the selected formulas were utilized to produce a layer-by-layer film. The results indicate that the concentrations of 0.4% w/v HPMC and 0.5% w/v of nanochitosan were successfully assembled into a layer-by-layer biodegradable film. Assessment based on multiple parameters (thickness, moisture content, water vapor transmission rate, color, transparency, and biodegradability) reveals that the deposition of nanochitosan onto HPMC in a layer-by-layer configuration enhances most characteristics of single-layer HPMC films, with the exception of optical properties. Moreover, all samples were degraded within a seven-day observation period.
Enhancing Firefly Algorithm for better Network lifetime optimization in Healthcare Monitoring System - Cloud Computing Environment
Authors: D. Raj Balaji K. Porkodi,
Published: December 2023

The Internet of Things (IoT), a new phenomenon in the technology industry, is mostly responsible for updating healthcare systems by gathering and analyzing patient physiological data through wearable technology and sensor networks. It is difficult to process so much data from so many IoT devices in such a short amount of time. Maximizing the network lifetime is one of the most significant tasks faced by any wireless sensor network. The objective of the study described in this paper was to apply swarm intelligence metaheuristics to optimize the cluster head selection. In order to extend the lifetime of the WSN, we have implemented both the original firefly algorithm (FA) and the proposal for the revised FA. Additionally, According to the proposed study, sensitive data is created and stored by IoT devices, which are vulnerable to attack, and data processing is handled by the edge server. Standard security algorithms like AES, DES, and RSA make it difficult for the majority of IoT devices to function successfully because of their restricted resources. For real-time processing, visualization, and diagnosis, the real-time data is subsequently sent to a distant cloud server.
Factors in The Formation of a Healthy Lifestyle Among University Students
Authors: Mirzaliyev Tolibjon Ganiyevich  , Mirzaliyeva Dilfuza Saminovna
Published: December 2023

The article is devoted to such issues as the further formation of a healthy lifestyle in society, strengthening the health of the population, educating a physically healthy and spiritually rich young generation, ensuring the broad involvement of citizens in physical culture and sports.
Teaching and Studying of Russian and English Languages in Educational Institutions of The Republic of Uzbekistan
Authors: Zhuraevа Mukhtasarkhon Abdukakhhorovna
Published: December 2023

This article discusses the problems of learning foreign languages in educational institutions of the Republic of Uzbekistan as an important means of international and interethnic communication. The analysis involves the Decree of the Government of the Republic of Uzbekistan “On measures to improve the teaching and learning of Russian and English languages in educational institutions of the Republic of Uzbekistan.” The author of the article pays special attention to the importance of a foreign language within the framework of a future profession when studying at an educational institution
The Use of Interactive Methods in The Teaching of Construction and Design of Sewing Products
Authors: Isaqova Zuhra Rafikovna  , Sotvoldiyev Elmurodjon Abdumannonovich  , Yuldashov Barxayotjon Toshpulatovich  , Akmalxon qizi
Published: December 2023

Currently, modern teaching methods are widely used in the educational process. The use of modern teaching methods leads to high efficiency in the teaching process. When choosing educational methods, it is appropriate to choose based on the didactic task of each lesson. The use of interactive methods in conducting practical training of the science of technological education gives high efficiency. This makes it possible for students to improve their qualifications and skills in science.
MANAGING THE HORIZON-ORIENTED IN-SITU LEACHING FOR THE URANIUM DEPOSITS OF MONGOLIA
Authors: Khomenko Oleh , Rudakov Dmytro , Lkhagva Tsandgjav , Sala Dariusz , Buketov Valentyn , Dychkovskyi Roman
Published: December 2023

This paper summarizes the results of evaluating uranium in-situ leaching (ISL) parameters for hydrogenous deposits in eastern Mongolia. This method, also known as in-situ recovery (ISR) or solution mining was proposed for mining used to extract uranium from underground deposits without physically removing the ore. The studies included drilling, geophysical surveying, evaluations of rock properties and chemical composition of rocks and groundwater, as well as modelling coupled flow and transport for the “Ul’zit” deposit as a case study. The proposed horizon-oriented approach to process separate ore bodies at different depths allows for the mining process to be adapted to layered heterogeneity and allows successive leaching by wells of varying diameter and special design. This approach may reduce drilling costs and shorten the time for mining uranium deposits in Mongolia by 2 times on average. It was proven that this method is an environmentally friendly and cost-effective alternative to traditional underground or open-pit mining for uranium ore bodies. The economic evaluation confirms the effectiveness of the proposed solutions.
CHEMICAL AND TEXTURAL STUDIES OF THE YOUNGEST PYROCLASTIC DEPOSITS AT MT. SEMINUNG (SOUTH SUMATRA, INDONESIA): A WINDOW FOR UNDERSTANDING THE EXPLOSIVE BEHAVIOR OF A POST-CALDERA VOLCANO
Authors: Gunawan Rachmi Mustika Pertiwi Putri , Suhendro Indranova
Published: December 2023

The youngest tephra deposits of Seminung Volcano in South Sumatra, Indonesia, was studied by addressing the stratigraphy (field data), componentry, petrography, glass and mineral compositions, and textural analysis of vesicles to interpret the magmatic system and eruption dynamics. Based on the componentry and grain size characteristics, the section is divided into three different units: (1) massive block and ash, (2) interbedded ash and lapilli, and (3) massive lapilli. All units include grey pumice (GP), brown pumice (BP), and scoria (SC) as the main juvenile types, while porphyritic lava occurs as the non-juvenile phase (lithics). Noteworthy, minor banded pumice (BaP) can be observed in all units, and accretionary lapilli (AL) is exclusive in the interbedded ash and lapilli unit. The similarity in mineralogy and the linear correlation of all major elements of glass compositions suggest that grey and brown pumice originated from the same shallow, biotite-bearing more silicic magma (64.5-74.9 wt. % ), while scoria originates from the deeper, biotite-free less silicic magma (62.1-69.2 wt. % ). The fact that grey pumice shows higher silica content and pheno-bubble fraction with lower phenocryst content than brown pumice suggests the rough stratification of the more silicic magma reservoir. Furthermore, the more silicic magma was likely intruded by the deeper less silicic magma, as indicated by the bimodal distribution of anorthite (An#) in grey and brown pumices (i.e. the peak of the high anorthite content is similar to that of scoria). Thus, the accumulation of pheno-bubble and magmatic recharge were likely responsible for triggering the eruption. Finally, the fact that juvenile clasts from units 2 and 3 had the highest matrix-vesicle number density (MVND) implies that the eruption intensity reached its peak towards the final eruption stage.
Speech disorders in genetically determined forms of epilepsy in children. Clinical observations
Authors: Guzeva Valentina I. , Eremkina Yulia A. , Guzeva Oksana V. , Guzeva Viktoriya V. , Malekov Damir A. , Vedernikova Viktoriya A.
Published: December 2023

BACKGROUND: Speech disorders in children are one of the pressing problems of child neurology. In recent years, much attention has been paid to studying the genetic aspects of the development of speech disorders in children with epilepsy. Speech function in childhood is vulnerable, and its violation has a number of significant consequences. Specialists from different disciplines focus on specific aspects of speech disorders. Speech therapists consider speech disorders based on linguistic criteria, psychologists evaluate the psychological characteristics of children with speech disorders. The rapid development of genetic research, the availability of many molecular genetic tests, especially such a method as next generation sequencing, allowed us to pay more attention to the study of genetic aspects of the development of speech disorders in children with epilepsy.
AIM: to present options for speech disorders in genetically determined forms of epilepsy in children based on clinical examples.
RESULTS: The article analyzes 3 clinical cases of epilepsy in children, combined with speech pathology (2 boys and 1 girl aged 2 to 5 years). The data of anamnesis of life and disease, neurological examination with assessment of speech function, results of genetic research, electroencephalographic examination and magnetic resonance imaging are presented.
CONCLUSION: All patients are united by a combination of speech disorders, epileptic seizures, and the presence of genetic pathologies that are responsible for speech function. These clinical observations demonstrate the need for a comprehensive, multidisciplinary approach both at the stage of early diagnosis of speech impairment in children with epileptic seizures and at the stage of further treatment of such patients.
Features of diagnosis, treatment and curation of patients with neuropathic pain syndrome of traumatic genesis
Authors: Kolomentsev Sergey V. , Litvinenko Igor'  V. , Tsygan Nikolay V. , Bulatov Albert R. , Gayvoronsky Alexey I. , Kolomentseva Anna V. , Polushina Natalia Y. , Ryabtsev Aleksandr V. , Panov Vladimir A. , Shermatyuk Evgeniy I. , Polezhaev Peter A. , Kirpichenko Anna A. , Yaroslavtseva Marina S.
Published: December 2023

BACKGROUND: The existing international and national clinical recommendations for the treatment of neuropathic pain syndrome are based mainly on the experience of providing care to patients with non-traumatic genesis of neuropathic pain. Approaches to the diagnosis, treatment and curation patients with neuropathic pain syndrome due damage of the nervous system as a result of wounds received during hostilities may differ from those in patients with somatic diseases.
AIM: To systematize the features of medical care and improve the methodological approach of curation patients with traumatic neuropathic pain syndrome.
MATERIALS AND METHODS: The practical experience of providing assistance to the wounded with traumatic lesions of the peripheral nervous system (including patients with phantom pain syndrome) accumulated by the staff of the Department and the Clinic of Nervous Diseases Military Medical Academy for 2022–2023 is summarized.
RESULTS: The features of inpatient routing, diagnosis, treatment and organization of medical care for patients with traumatic neuropathic pain syndrome at the stage of a specialized medical institution are systematized. The practical aspects of the curation patients with neuropathic pain due to wounds received during hostilities, related to the appointment of medications (including narcotic analgesics), regional anesthesia and the provision of neurosurgical care are highlighted. A separate emphasis is placed on the importance of assessing the mental state and quality of sleep of the wounded with neuropathic pain syndrome, the features of drug correction identified disorders. Practical recommendations for the treatment of patients based on the results of assessing the severity neuropathic pain syndrome using a daily graphic pain diary are presented.
CONCLUSION: The revealed differences in therapeutic and diagnostic approaches in providing medical care to the wounded with traumatic neuropathic pain syndrome, the importance of interdisciplinary interaction different specialties doctors (neurologists, surgeons, traumatologists, neurosurgeons, psychiatrists) at the early stages of treatment indicate the need to develop separate recommendations for the treatment of neuropathic pain in victims of armed conflicts.
Nodopathy: clinic, diagnosis, treatment. Clinical description
Authors: Bulatov Al'bert R. , Litvinenko Igor' V. , Tsygan Nikolay V. , Bardakov Sergey N. , Boykova Aleksandra A. , Kolesnik Tatyana A. , Onishchenko Lyudmila S.
Published: December 2023

AIM: Evaluation of the significance and possibilities of laboratory-instrumental diagnostic methods in establishing the diagnosis and selection of targeted therapy in patients with nodopathies.
MATERIALS AND METHODS: System analysis of data from foreign and domestic literature with the presentation of a clinical case.
RESULTS: Polyneuropathies are classified as demyelinating or axonal based on electrophysiological studies. However, in 2015, in addition to axonal and demyelinating neuropathies, it was proposed to distinguish a separate pathophysiological group — nodopathies. The pathogenesis of nodopathies may differ depending on the type of ion channels involved in the process, but always leads to a loss of excitability of the axon membrane; in the nodal region the membrane becomes inexcitable. Such neuropathies are characterized by transient conduction blocks followed by the development of axonal degeneration. Typical examples of nodopathies are acute motor axonal neuropathy, as well as multifocal motor neuropathy. Current pathophysiological understanding of specialized nodal regions (nodes of Ranvier) and associated axoglial proteins is growing. Hypotheses have been put forward about their role in the pathogenesis of immune-mediated attack on the peripheral myelinated axon. Recently, high titers of antibodies directed against a number of key adhesion molecules have been identified in both acute and chronic inflammatory neuropathies. These facts add to the differences in differential diagnosis between axonal and demyelinating peripheral neuropathies. New disease classification schemes based on seropositivity, improved electrophysiological and ultrasound classification, and identification of putative underlying pathological targets and mechanisms are being rapidly developed.
CONCLUSION: Using our clinical example, we demonstrated the capabilities of laboratory and instrumental diagnostic methods in establishing a diagnosis in a patient with one of the forms of nodopathies — multifocal motor neuropathy.
Assessment and Management of Ischaemic Heart Disease in Non-Cardiac Surgery
Authors: Morgan Holly ,   British Heart Foundation Centre of Research Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences, King’s College, London, UK, Ezad Saad M ,   British Heart Foundation Centre of Research Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences, King’s College, London, UK, Rahman Haseeb ,   British Heart Foundation Centre of Research Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences, King’s College, London, UK, De Silva Kalpa ,   British Heart Foundation Centre of Research Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences, King’s College, London, UK, Partridge Judith S L ,   British Heart Foundation Centre of Research Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences, King’s College, London, UK,   Guy’s and St Thomas’ NHS Foundation Trust, London, UK, Perera Divaka ,   British Heart Foundation Centre of Research Excellence at the School of Cardiovascular and Metabolic Medicine and Sciences, King’s College, London, UK,   Guy’s and St Thomas’ NHS Foundation Trust, London, UK
Published: December 2023

In the setting of non-cardiac surgery, cardiac complications contribute to over a third of perioperative deaths. With over 230 million major surgeries performed annually, and an increasing prevalence of cardiovascular risk factors and ischaemic heart disease, the incidence of perioperative myocardial infarction is also rising. The recent European Society of Cardiology guidelines on cardiovascular risk in non-cardiac surgery elevated practices aiming to identify those at most risk, including biomarker monitoring and stress testing. However the current evidence base on if, and how, the risk of cardiac events can be modified is lacking. This review focuses on patient, surgical and cardiac risk assessment, as well as exploring the data on perioperative revascularization and other risk-reduction strategies.
Limb-Girdle Muscular Dystrophy in Brazilian children: Clinical, histological and molecular characterization.
Authors: Albuquerque Marco
Published: December 2023

Limb-girdle muscular dystrophies (LGMD) are a heterogeneous group of genetic muscular disorders, involving autosomal recessive and dominant forms, that clinically are characterized by progressive muscular weakness of proximal predominance, generally starting in the pelvic girdle and, later, in the shoulder girdle, frequently associated with other clinical signs such as calf hypertrophy, joint retractions and skeletal deformities such as winging scapula and scoliosis. The distal muscles may be affected, but usually only late in the progression of the disease. Involvement of respiratory muscles and cardiac muscles is described in many forms of the disease. Different degrees of increase in the serum level of creatine kinase (CK) are observed and, sporadically, there is involvement of the central nervous system (CNS) and gastrointestinal tract . Autosomal recessive forms are far more common than autosomal dominant, particularly in children. Significant overlap of clinical phenotypes, with genetic and clinical heterogeneity, constitutes the rule for this group of diseases. Muscle biopsies are useful for histopathologic and immunohistochemical studies and the confirmatory toll is the molecular test . This retrospective study had the objective to investigate the frequency of different subtypes of limb-girdle muscular dystrophy in children from a population from a large public teaching hospital serving the country, describing the clinical and histological aspects of the different forms.
Nurse Compliance of Electronic Nursing Care Documentation in Inpatient Rooms
Authors: Prasetyowati Erny , Widiyanto Puguh , Nugroho Sri Hananto Ponco
Published: December 2023

Electronic Nursing Care contains various record files, such as medical records of doctors, nurses, and other health workers who collaborate to provide health services. Documentation of nursing care can be hampered due to several factors, such as nurse's knowledge, attitude, motivation, and compliance. This study aims to determine the relationship between factors of nurse compliance in documenting nursing care using Electronic Medical Records. This study used a cross-sectional approach with 41 subjects selected using total sampling. The data obtained was tested using the Spearman Rank test using IBM Statistics 25 for Windows. The measuring tool used was a questionnaire of knowledge, attitudes, motivation, and observations regarding compliance with filling out nursing care. The result obtained produced a p of 0.000 (p <0.05). There was a significant relationship between the knowledge, attitudes, and motivation of nurses with compliance in documenting nursing care using electronic medical records with the strength of a strong relationship with a positive pattern, meaning that the better the level of knowledge, attitudes, and motivation of nurses, the more obedient they will be toward documentation of nursing care with electronic medical records.
Analysis of Barriers Implementation Health Information Technology Using Vosviewer: A Bibliometric Study
Authors: Haryanto Latifah Mutiara , Setyonugroho Winny , Suanrueang Passakorn
Published: December 2023

Information technology is growing rapidly in various fields, especially in health services. The development of information technology in health services is e-health, which aims to improve public health, expand and reach health services, and manage patients in real-time. This study aims to determine the publication trend of articles on barriers to medical technology implementation from 2015 – 2022. The publications were retrieved through a search through the Scopus database and obtained 422 publications. This study analyzed the number of publications per year, document type, most contributing countries, subject area of publication, influential authors, number of article citations, and contributing search sources. This study also analyzed and collated documents with Vos Viewer. The results showed that the trend of publications has increased the number of publications from year to year. The types of papers published with the highest number were articles (322 publications) and reviews (90 publications). The most contributing country was the United States, with 191 reports. The dominant subject area was medicine, at 66.23%. The publication with the most citations was an article by Scott Kruse et al. entitled “Evaluating Barriers to Adopting Telemedicine Worldwide: A Systematic Review” from the Journal of Telemedicine and Telecare, with the subject area of medicine having 413 citations. Researchers with the highest number of publications (3) were ten authors. The study was limited by the search for literature from a single database, which allowed the literature to not cover all of the literature on barriers to medical technology implementation.
Compliance with Clinical Pathways and Pilot Implementation Impact on Financial Outcome in Hospitals Using National Health Insurance: An Action Research
Authors: Riandini Rien Rahmi , Arifiyanto Achmad Yudi , Rochmah Thinni Nurul , Chalidyanto Djazuly , Purwaningtyas Raissa Manika
Published: December 2023

Payment for health services with national health insurance applies a prospective method. Hospitals must make efforts so that health services can run efficiently and not cause losses. The problem in this research is the negative difference between the Indonesian Case Based Group (INA-CBG) rates and service costs based on actual patient rates with national health insurance. This study aimed to develop a clinical pathway on 10 top CBG codes with the largest negative differences between INA-CBG and hospital rate. It also evaluated its pilot implementation impact on financial outcomes. Action research was conducted on a sample of the top 10 Case Based Group (CBG) codes with the largest negative difference between INA-CBG rates. One thousand ninety-nine (1099) medical records were analyzed and taken randomly using simple random sampling. Most of the variants found were the provision of consumable medical materials that exceeded standards and the administration of patent medicines outside the national formulary without written medical indications. The value of compliance with the clinical pathway was still below the expected standard (< 80%), especially in medical consumables. Researchers carried out a three-month intervention of a new clinical pathway implementation. The results showed increased compliance with clinical pathways and reduced negative differences between INA-CBG and hospital rates. Clinical pathway audits could reduce the negative difference between INA-CBG and hospital rates.
Legal Protection of Hospitals as Whistleblowers According to the Republic of Indonesia Act Number 17 of 2023 Concerning Health in Cases Involving Fake Doctors
Authors: Sarwono Aditya Pratama
Published: December 2023

This research explores legal protection for hospitals as whistleblowers in doctor identity forgery cases, emphasizing the Act of the Republic of Indonesia Number 17 of 2023 on Health in Indonesia. These cases, as seen in Primasatya Husada Citra Hospital (PHC) Surabaya, revealed vulnerabilities in the healthcare system to individuals without proper qualifications, highlighting the potential criminal penalties for hospital directors due to negligence in recruiting fake doctors. This research aims to delve into the Health Law's content and find strategies to help hospitals minimize criminal liability risks and ensure compliance with this law. The focus of the analysis will be on key legal aspects affecting the legal protection of hospitals in reporting cases of doctor identity forgery. The results will provide valuable guidance to hospitals in maintaining the integrity of healthcare services, protecting hospitals, and ensuring the safety of patients from the challenges of doctor identity forgery by irresponsible individuals.