bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSISTÊNCIA À SAÚDE NOS TRANSTORNOS MENTAIS NO PERÍODO DE PUERPÉRIO: REVISÃO INTEGRATIVA
Authors: Maurício da Silva Josepson , De Tarso Alves e Silva Ronny , Pereira da Silva Tânia , Lopes da Silva Maciel , Alves Geraci Naira , Paulo Valentim Dantas Luis , Tavares Venâncio Romário
Published: September 2023

Introdução: No puerpério, a mulher passa por intensas mudanças de ordem familiar e social, como também de adaptações psicológicas e biológicas, que são marcadas por alterações metabólicas e hormonais complexas, sendo a fase de maior risco para o desenvolvimento de algum transtorno mental. Objetivo: Realizar uma revisão da literatura para identificar a assistência à saúde nos transtornos mentais no período de puerpério. Metodologia: Estudo descritivo na modalidade revisão integrativa, realizado com artigos originais disponíveis nas línguas portuguesa, inglesa e espanhola, publicados nas bases de dados Scientific Electronic Library Online (SCIELO) e Literatura Latino-Americana em Ciências da Saúde (LILACS), no período de 2015 a 2021 com os seguintes descritores: assistência de enfermagem, transtornos mentais e período pós-parto. Resultados: Foram encontrados 58 artigos, dos quais 17 foram selecionados ao final do processo. 10 trabalhos evidenciaram fatores associados com transtorno mental, 4 trabalhos descreveram medidas de proteção e 3 abordam ações assistenciais de saúde na intervenção dos transtornos mentais no puerpério. Conclusões: Após análise da literatura, observamos que o baixo suporte social e familiar se mostraram como principais fatores de risco associados aos transtornos mentais para a puérpera. Já os fatores de proteção foram relacionados com aumento do apoio familiar e assistencial por meio dos serviços de saúde, bem como a importância da enfermagem na implementação de estratégias preventivas para os transtornos mentais no puerpério.
DEPENDÊNCIA FUNCIONAL DENTRO E FORA DE CASA EM PESSOAS IDOSAS COM 75 ANOS OU MAIS: DIFERENÇAS ENTRE OS SEXOS
Authors: Alves Erika Valeska Costa , Leme Daniel Eduardo Cunha , Lima Maria do Carmo  Correia de , Guimarães Márcia Alves , Borim Flávia Silva Arbex , Fattori André
Published: September 2023

Introdução: O sexo é um importante fator a ser considerado na compreensão da dependência de cuidados na velhice, uma vez que rege diferentes oportunidades sociais e intelectuais, ao longo do curso de vida.  Objetivo: Verificar fatores associados à dependência, dentro e fora de casa, em pessoas idosas com 75 anos ou mais, com ênfase na diferença entre os sexos. Metodologia: Pesquisa transversal com dados do estudo FIBRA. A capacidade funcional nas Atividades Instrumentais de Vida Diária (AIVDs) foi dividida em atividades realizadas dentro de casa (uso do telefone, manejo da medicação, tarefas domésticas e preparo da refeição) e atividades realizadas fora de casa (fazer compras, utilizar transporte e manejo do dinheiro). As variáveis independentes incluíram aspectos sociodemográficas e de saúde. Foram estimadas razões de prevalência por meio de modelos de regressão múltipla de Poisson a fim de verificar as variáveis associadas com dependência dentro e fora de casa. Resultados: A amostra foi composta por 804 idosos. Dentro de casa, não houve fatores associados à dependência para o sexo masculino. Enquanto para o sexo feminino, os fatores associados foram fragilidade (RP = 1,99; 95%IC: 1,26-3,15) e 80 anos e mais (RP = 1,41; 95%IC: 1,05-1,89). Quanto à dependência fora de casa, a fragilidade destacou-se como um fator associado a ambos os sexos, masculino (RP = 2,80 95%IC: 1,17-6,64) e feminino (RP = 1,98 95%IC: 1,24-3,17). Conclusões: Para o sexo feminino, a idade avançada e a fragilidade foram os fatores de maior associação com dependência, tanto para o ambiente dentro quanto fora de casa. Para o sexo masculino, a fragilidade foi o único e grande determinante de dependência nas atividades fora de casa, apresentando prevalência maior do que a encontrada na amostra do sexo feminino.
Salivary Antiviral and Antibacterial Properties in the Encounter of
SARS-CoV-2
Authors: Mohtasham Nooshin , Bargi Rahimeh , Farshbaf Alieh , Shahri Maryam Vahabzadeh , Hesari Kiana Kamyab , Mohajertehran Farnaz
Published: September 2023

Due to the high mortality rate of COVID-19 and its high variability and mutability, it is essential to
know the body's defense mechanisms against this virus. Saliva has numerous functions, such as digestion, protection,
and antimicrobial effects. Salivary diagnostic tests for many oral and systemic diseases will be available
soon because saliva is a pool of biological markers. The most important antiviral and antibacterial compounds
identified in saliva include lysozyme, lactoferrin (LF), mucins, cathelicidin, salivary secretory immunoglobulin
(SIgA), chromogranin A, cathelicidin, salivary agglutinin (SAG) (gp340, DMBT1), α, β defensins, cystatin,
histatins, secretory leukocyte protease inhibitor (SLPI), heat shock protein (HSP), adrenomedullin and microRNA
(miRNAs). Antimicrobial peptides (AMPs) in saliva could be used in the future as models for designing
effective oral microbial antibiotics. The antiviral properties of the peptides in saliva may be one of the future
treatments for the COVID-19 virus. In this review, we investigate compounds with antiviral and antibacterial
properties in saliva and the importance of these compounds in saliva in exposure to the COVID-19 virus.
Due to the transmission route of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) into the oral
cavity in the lower and upper respiratory tract, studies of salivary antiviral properties in these patients are very
important. Some of the antiviral effects of saliva, especially mucin, α, β-defensins, IgA, IgG, IgM, lysozyme,
SAG, SLPI, and histatins, may play a greater role in neutralizing or eliminating COVID-19.
High Mobility Group Box 1 Protein: A Plausible Therapeutic Molecular
Target in Parkinson’s Disease
Authors: Goyal Ahsas , Agrawal Anant , Dubey Nandini , Verma Aanchal
Published: September 2023

Parkinson’s disease (PD) is a widespread neurodegenerative disorder that exerts a broad
variety of detrimental effects on people’s health. Accumulating evidence suggests that mitochondrial
dysfunction, neuroinflammation, α-synuclein aggregation and autophagy dysfunction may all
play a role in the development of PD. However, the molecular mechanisms behind these pathophysiological
processes remain unknown. Currently, research in PD has focussed on high mobility
group box 1 (HMGB1), and different laboratory approaches have shown promising outcomes to
some level for blocking HMGB1. Given that HMGB1 regulates mitochondrial dysfunction, participates
in neuroinflammation, and modulates autophagy and apoptosis, it is hypothesised that
HMGB1 has significance in the onset of PD. In the current review, research targeting multiple
roles of HMGB1 in PD pathology was integrated, and the issues that need future attention for targeted
therapeutic approaches are mentioned.
Research Progress on hCNT3 Structure/Function and Nucleoside Anticancer
Drugs
Authors: Yue Xinru , Zhang Xun , Zhang Derong , Zhang Zhigang , Tang Lingkai , Ou Zuoxin , Cao Yujie , Li Jing , Li Ying , Liang Li , Liu Wei , Hu Jianping
Published: September 2023

Membrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only
transport extracellular nucleosides into the cell but also transport various nucleoside-derived anticancer
drugs to the focus of infection for therapeutic effects. Typical nucleoside anticancer drugs,
including fludarabine, cladabine, decitabine, and clofarabine, are recognized by hCNT3 and then
delivered to the lesion site for their therapeutic effects. hCNT3 is highly conserved during the evolution
from lower to higher vertebrates, which contains scaffold and transport domains in structure
and delivers substrates by coupling with Na+ and H+ ions in function. In the process of substrate delivery,
the transport domain rises from the lower side of transmembrane 9 (TM9) in the inward conformation
to the upper side of the outward conformation, accompanied by the collaborative motion
of TM7b/ TM4b and hairpin 1b (HP1b)/ HP2b. With the report of a series of three-dimensional
structures of homologous CNTs, the structural characteristics and biological functions of hCNT3
have attracted increasing attention from pharmacists and biologists. Our research group has also recently
designed an anticancer lead compound with high hCNT3 transport potential based on the
structure of 5-fluorouracil. In this work, the sequence evolution, conservation, molecular structure,
cationic chelation, substrate recognition, elevator motion pattern and nucleoside derivative drugs of
hCNT3 were reviewed, and the differences in hCNT3 transport mode and nucleoside anticancer
drug modification were summarized, aiming to provide theoretical guidance for the subsequent
molecular design of novel anticancer drugs targeting hCNT3.
Donating One’s Body to HIV Cure Research Through Canadian Medical Assistance in Dying: A Case Study
Authors: Lessard David , Lebouché Bertrand , Morneau André , Bilodeau Martin , Rosenes Ron , Sanders Justin , Chomont Nicolas , Keeler Patrick , Dubé Karine , Margolese Shari , Jenabian Mohammad Ali , Power Christopher , Routy Jean-Pierre , Angel Jonathan B. , Cohen Éric A. , Costiniuk Cecilia T.
Published: September 2023

Background:

Finding a cure for HIV is challenged by persisting reservoirs, the mapping of
which necessitates invasive procedures. Inviting people with HIV (PWHIV) at the end of life to donate
body specimens post-mortem through research autopsies is a novel approach, raising ethical
concerns.

Objective:

This case study aims to explore the motivations, barriers, and facilitators of a terminally-ill
Canadian PWHIV who requested medical assistance in dying (MAID) and expressed interest in donating
his body for HIV cure research.

Case Presentation:

An in-depth 3-hour and semi-structured interview was conducted with the participant.
The interview transcription was thematically coded to identify motivations and perceived barriers
and facilitators to participate in end-of-life HIV cure research. Our analysis identified six themes.
Two themes expressed motivations: Collaboration in progress in health and science, seeing cure
research as collaboration with professionals; and Opportunity to learn more, mostly about science and
health. One theme expressed a barrier: Losing interest in or identification with long-term care research
matters, especially those related to the management of long-term care. Three themes expressed
by facilitators: Receiving information from professionals one trusts and knows, especially clinical and
research teams; Perceiving research procedures as simple, useful, and embedded in care, perceiving
clinical, educational, and interpersonal benefits that surpass costs of participation; and Perceiving
research as one last way to contribute, that is, feeling useful or give back.

Conclusion:

Several circumstances facilitated the patient’s participation: being a single man, having
time to participate, having no strong religious belief, and valuing clear, direct communication. His
motivations to participate in HIV cure research were altruistic, and also an experience of working
with clinical and research teams. Finally, this perspective highlights HIV cure research participant
candidates’ need for education about research procedures.
Role of Apoptosis in the Pathogenesis of Osteoarthritis: An Explicative
Review
Authors: Arora Deepshi , Taneja Yugam , Sharma Anjali , Dhingra Ashwani , Guarve Kumar
Published: September 2023

Apoptosis is a complex regulatory, active cell death process that plays a role in cell development,
homeostasis, and ageing. Cancer, developmental defects, and degenerative diseases are
all pathogenic disorders caused by apoptosis dysregulation. Osteoarthritis (OA) is by far the most
frequently diagnosed joint disease in the aged, and it is characterized by the ongoing breakdown of
articular cartilage, which causes severe disability. Multiple variables regulate the anabolic and
catabolic pathways of the cartilage matrix, which either directly or indirectly contribute to cartilage
degeneration in osteoarthritis. Articular cartilage is a highly specialized tissue made up of an extracellular
matrix of cells that are tightly packed together. As a result, chondrocyte survival is crucial
for the preservation of an optimal cartilage matrix, and chondrocyte characteristics and survival
compromise may result in articular cartilage failure. Inflammatory cytokines can either promote or
inhibit apoptosis, the process of programmed cell death. Pro-apoptotic cytokines like TNF-α can induce
cell death, while anti-apoptotic cytokines like IL-4 and IL-10 protect against apoptosis. The
balance between these cytokines plays a critical role in determining cell fate and has implications
for tissue damage and disease progression. Similarly, they contribute to the progression of OA by
disrupting the metabolic balance in joint tissues by promoting catabolic and anabolic pathways.
Their impact on cell joints, as well as the impacts of cell signalling pathways on cytokines and inflammatory
substances, determines their function in osteoarthritis development. Apoptosis is evident
in osteoarthritic cartilage; however, determining the relative role of chondrocyte apoptosis in
the aetiology of OA is difficult, and the rate of apoptotic chondrocytes in osteoarthritic cartilage is
inconsistent. The current study summarises the role of apoptosis in the development of osteoarthritis,
the mediators, and signalling pathways that trigger the cascade of events, and the other inflammatory
features involved.
Potential Benefits of Psilocybin for Lupus Pain: A Case Report
Authors: Gonzales Sofia Audrey B. , Alexopoulos Christine , Arkfeld Daniel G.
Published: September 2023

Introduction:

Outcomes of treatment for patients with Lupus have shown overall improvement
and benefit from the more aggressive use of immunosuppressants and biological agents
through a treat-to-target approach. However, chronic musculoskeletal pain can be refractory to
treatment despite the use of non-steroidal anti-inflammatory drugs, corticosteroids, and other analgesic
agents, leading to patient dissatisfaction. The concept of new neural pathways from psilocybin
usage has been proposed in a variety of pain syndromes; however, it is not trialed for patients
with Lupus pain.

Case Presentation:

The patient was a 67-year-old male with positive anti-dsDNA antibody Lupus
with a predominance of chronic polyarticular joint pain treated with hydroxychloroquine and non-steroidal
anti-inflammatory drugs without pain relief. Pain dramatically improved after a one-time
macro-dosing of 6 grams of Psilocybin cubensis in Oregon, which he expected would only provide
a sense of enlightenment. After 12 months, he continued without debilitating joint pain.

Conclusion:

The serotonin-2A receptor’s activation triggers an array of neurophysiological reactions
that disrupt the functional connections in areas of the brain that are associated with chronic
pain. These neuroplastic effects can generate healthy connections, resulting in long-lasting pain relief.
However, this is a process that has not been fully analyzed. While there is anecdotal evidence
to suggest the therapeutic benefits for autoimmune diseases, including rheumatoid arthritis and psoriasis,
there is no specific research that explores its use for lupus-related pain. Since this is the first
case that shows the benefit of psilocybin in a patient with Lupus, further studies on macro-dosing
psilocybin to treat Lupus pain are warranted.
Mammography and Ultrasonography Manifestations of Sclerosing Lymphocytic
Lobulitis of the Breast: A Series of Seven Case Reports
Authors: Lin Wanling , Bao Lingyun
Published: September 2023

Objective:

The present study aimed to analyze mammography and ultrasonography (US) manifestations of sclerosing lymphocytic lobulitis (SLL) of the breast.

Methods:

A total of 8 pathologically confirmed SLL lesions from seven women (with one patient having bilateral breast lesions) were included in the study. All patients underwent preoperative mammography and US examinations. The findings from both modalities were classified and compared to their corresponding clinical data.

Results:

Four patients were diagnosed with diabetes mellitus. Mammography results revealed that seven lesions presented as focal asymmetry or asymmetry. Seven lesions were observed as non-mass lesions on US examination. The most commonly observed US lesion features were as follows: seven lesions had focal non-ductal hypoechoic areas (87.5%), seven lesions exhibited posterior shadowing (87.5%), all lesions showed no vascularity or vessels in the rim (100%), no lesion had calcifications (0%), five lesions had an elasticity score of 3 (100%), one lesion showed retraction on the coronal plane (20%), and one lesion displayed a skipping sign on the coronal plane (20%). Based on these US findings, seven lesions (87.5%) were classified as BI-RADS 4.

Conclusion:

The mammography findings for SLL are often nonspecific. However, the US features of SLL typically present as non-mass lesions. The absence of calcification and vascularity and no retraction on the coronal plane inside the lesion may help to differentiate this disease from the conventional forms of breast carcinoma.
Characterization of Central and Nasal Orbital Adipose Stem Cells and
their Neural Differentiation Footprints
Authors: Sanie-Jahromi Fatemeh , Nowroozzadeh M. Hossein , Shaabanian Mina , Khademi Behzad , Owji Naser , Mehrabani Davood
Published: September 2023

Background:

The unique potential of stem cells to restore vision and regenerate damaged ocular cells has led to the increased attraction of researchers and ophthalmologists to ocular regenerative medicine in recent decades. In addition, advantages such as easy access to ocular tissues, non-invasive follow-up, and ocular immunologic privilege have enhanced the desire to develop ocular regenerative medicine.

Objective:

This study aimed to characterize central and nasal orbital adipose stem cells (OASCs) and their neural differentiation potential.

Methods:

The central and nasal orbital adipose tissues extracted during an upper blepharoplasty surgery were explant-cultured in Dulbecco’s Modified Eagle Medium (DMEM)/F12 supplemented with 10% fetal bovine serum (FBS). Cells from passage 3 were characterized morphologically by osteogenic and adipogenic differentiation potential and by flow cytometry for expression of mesenchymal (CD73, CD90, and CD105) and hematopoietic (CD34 and CD45) markers. The potential of OASCs for the expression of NGF, PI3K, and MAPK and to induce neurogenesis was assessed by real-time PCR.

Results:

OASCs were spindle-shaped and positive for adipogenic and osteogenic induction. They were also positive for mesenchymal and negative for hematopoietic markers. They were positive for NGF expression in the absence of any significant alteration in the expression of PI3K and MAPK genes. Nasal OASCs had higher expression of CD90, higher potential for adipogenesis, a higher level of NGF expression under serum-free supplementation, and more potential for neuron-like morphology.

Conclusion:

We suggested the explant method of culture as an easy and suitable method for the expansion of OASCs. Our findings denote mesenchymal properties of both central and nasal OASCs, while mesenchymal and neural characteristics were expressed stronger in nasal OASCs when compared to central ones. These findings can be added to the literature when cell transplantation is targeted in the treatment of neuro-retinal degenerative disorders.
Deciphering the Role of Peroxisome Proliferator-activated Receptor α and
Phosphodiesterase Type 5 Targets in Alzheimer's Disease
Authors: Sose Parnika M. , Kale Pravin P. , Doshi Gaurav M.
Published: September 2023

The most prevalent cause of dementia is Alzheimer's disease (AD). Although the global AD
rate is on a constant rise, medical research is yet to find a cure for this neurological condition. Current
available therapeutic drugs for AD treatment only provide symptomatic alleviation. Therefore, it is essential
to establish effective AD treatment strategies in addressing clinical needs. The development of
disease-modifying treatments for use in the disease's early stages and the advancement of symptomatic
drugs principally used in the disease's later stages are priorities in AD research. Given that the etiology
of AD is difficult to comprehend, using a multimodal therapy intervention that targets molecular targets
of AD-related degenerative processes is a practical strategy to change the course of AD progression.
The current review article discussed PPAR-α (Peroxisome proliferator-activated receptor-α) and
PDE5 (Phosphodiesterase type 5) targets with evidence for their preclinical and clinical importance.
Furthermore, we support the targets with AD-related processes, functions, and remedial measures. A
unique synergistic method for treating AD may involve the beneficial combinatorial targeting of these
two receptors. Furthermore, we reviewed different PDE chemical families in this research and identified
PDE5 inhibitors as one of the promising AD-related experimental and clinical disease-modifying
medications. Lastly, we suggest jointly targeting these two pathways would be more beneficial than
monotherapy in AD treatments.
Protecting Cloud Computing Environments from Malicious Attacks using Multi-factor Authentication and Modified DNA Cryptography
Authors: Rawther Shiju , Sivaji Sathyalakshmi
Published: September 2023

Introduction:

Cloud computing has become an essential technology for data storage and
sharing, but security concerns remain significant challenges. Authentication is one of the critical
components of cloud security. Various authentication schemes have been proposed to ensure the
confidentiality and integrity of cloud data.

Method:

This research paper reviews the state-of-the-art three-factor authentication schemes based
on smart cards, biometric authentication, and elliptic curve cryptography. The paper also presents a
comprehensive overview of DNA cryptography algorithms, which have recently gained popularity
due to their unique features in cloud data security. The paper further compares the DNA cryptography
algorithms and discusses their advantages and disadvantages in terms of security and performance.

Results:

Finally, the paper proposes an efficient and secure DNA-based authentication scheme for
cloud computing. This scheme is validated using all these types of data, and its performance is evaluated
in terms of encryption and decryption times. Decryption takes 60 seconds on average and encryption
40 seconds on average.

Conclusion:

As a final evaluation, it establishes that the proposed system can provide secure cloud
services.
Fabrication of Eucalyptus Oil-loaded Ciprofloxacin Hydrochloride Topical
Films for Enhanced Treatment of Post-Operative Wound Infection
Authors: Parmar Rakeshkumar , Kalal Nimisha , Patel Janki , Chauhan Payal
Published: September 2023

Background:

The efficacious penetration of antimicrobials at infectious sites and the reduction of microbial resistance development are critical in controlling the effective treatment of post-operative wound infection.

Methods:

To create the enhanced antimicrobial topical films, a solvent casting method for ciprofloxacin hydrochloride (CiproHCl) loaded eucalyptus oil (EO) containing low molecular weight chitosan films was used. Nine batches of CiproHCl with varying chitosan and glycerol concentrations were prepared and tested. Additionally, optimised CiproHCl films with EO were created and tested. The antimicrobial activity of CiproHCl-loaded EO containing low molecular weight chitosan films against S. Aureus, E. Coli, and B. Subtilus was tested.

Results:

The FT-IR spectroscopy and DSC analysis revealed no interaction between the drug and any of the other excipients, and the drug remained amorphous in chitosan film. The SEM analysis revealed that the prepared CiproHCl-loaded EO-containing films had smooth surfaces and large agglomerates. In vitro drug release testing revealed that the EO-loaded films have a sustained release profile of up to 16 hours with a cumulative drug release of 96.83%. In an ex vivo drug permeation study, CiproHCl-loaded EO-containing films demonstrated 2.44 times more permeation flux than CiproHCl-alone films. After six months, the stability study revealed that the CiproHCl-loaded EO-loaded EO-containing film showed no significant change in drug release profile or folding endurance.

Conclusion:

This present study highlights the possible usage of CiproHCl-loaded EO containing low molecular weight chitosan films in enhanced post-operative wound treatment.
Hybrid Aluminized Fiberglass Reinforced Composite Pipes: A Framework for Safety Use in Industries
Authors: Vasanthanathan Arunachalam , Narayanan Umesh Pattu Sowmya , Amudhan Kannan
Published: September 2023

Introduction:

Polymer matrix composites have been utilized in various industries
due to their low cost and good strength-to-weight ratios. AIM: This study aims to
investigate the effectiveness of filament-wound fiber-reinforced polymer composite
pipes. The focus is on aluminized fabric tubes, which are flexible and heat-resistant tubes
made from a glass fabric and laminated with a layer of aluminum.

Method:

These tubes offer unique properties that make them suitable for various applications,
especially in environments with high temperatures or exposure to radiant heat.
Fiber Reinforced Plastic (FRP) pipes are highlighted for their lightweight, easy transportation,
low maintenance, corrosion resistance, design flexibility, and anti-freezing performance.
The study delves into the use of aluminized glass fiber for high-temperature
applications, with a specific focus on enhancing high-temperature withstanding properties.

Result:

In addition, the present research also conducts tests to study the structural
strength of normal glass fabric tubes and aluminized glass fabric tubes. The fabrication
of composite pipes is achieved through a filament winding process with a zero-degree
winding angle using a manually operated filament winding machine. Mechanical testing
and Finite Element Analysis (FEA) simulations using ANSYS® are also performed to
compare glass fiber-reinforced plastic pipes with hybrid aluminized fiber-reinforced
plastic pipes.

Conclusion:

The application of aluminized glass fiber in both the internal and external
layers of the pipes improves the pipe’s strength and ability to endure high temperatures.
Investigation of Reported Anaphylaxis Post COVID-19 Vaccination in
Subjects with History of Allergies and Anaphylaxis
Authors: Desai Aditya P. , Desai Aryan P. , Ochs Victoria S. , Desai Prashant V.
Published: September 2023

Background:

Two mRNA COVID-19 vaccines, Pfizer-BioNTech and Moderna, are currently
approved in the United States, and one viral-vector vaccine, J&J/Janssen, is authorized for limited use.
The Vaccine Adverse Event Reporting System (VAERS) database gathers reports of adverse effects, including anaphylaxis.

Objective:

In this manuscript, we provide a summary of reported incidence of anaphylaxis rates following
administration of the two mRNA and one viral-vector COVID-19 vaccine.

Methods:

A detailed investigation of the relative risk of anaphylaxis for recipients with or without a prior
history of allergy and/or anaphylaxis is also described.

Results:

Overall reported incidence of anaphylaxis is 4.49 [95% CI: 0.25 – 8.73] cases per million doses
administered.

Conclusion:

The reported risk of anaphylaxis is 1.83 times greater for recipients with prior allergies and
no anaphylaxis but 17.70 times greater for recipients with prior allergies and anaphylaxis.
Analysis of students’ perceptions on the Freedom of Learning - Independent Campus (MBKM) program at Chemistry study program of Ma Chung University
Authors: Yuniati Yuyun , Wilujeng Lilis Lestari
Published: September 2023

Considering that Indonesian education has gone through such a long journey from 1922 to 2022 now, it is necessary to have an educational program that is able to meet the demands of workers' needs in this era of globalization. In the end, the Directorate General of Higher Education, Research, and Technology designed an education policy system in the realm of higher education, namely "Freedom of Learning - Independent Campus", as an accurate strategy for optimizing academics in today's Indonesia. In this study, a survey was aimed at 40 undergraduate students of the Chemistry Study Program at Ma Chung University. Data analysis were made by quantitative approach of the nine questions succcessfully answered by students who filled out questionnaires in the online multiple choice questionnaire with a dependency test by nonparametric statistical methods. As a result, the majority of students of the Chemistry Study Program were quite enthusiastic about this new educational policy, although it was necessary to optimize all internal strategies of the study program curriculum, so that it could be in accordance with the activities designed in the "Freedom of Learning - Independent Campus" Program.
A study of the readiness of post-pandemic computer-based four-tier diagnostic test (CBFTDT): A review of economic level, school grades, and device accessibility
Authors: Istiyono Edi , Dwandaru Wipsar Sunu Brams , Ayub Made Rai Shanti , Saepuzaman Duden , Zakwandi Rizki , Rachman Anisyah , Yusron Eri , Santoso Purwoko Haryadi
Published: September 2023

Student readiness for using computer-based assessment was affected by economic level, school grade, and device accessibility. This study analyzed student readiness using a computer-based assessment, the four-tier diagnostic test (CBFTDT). The data in this study were students' responses to a questionnaire consisting of 16 statements about three aspects: mental access, skill access, and usage. The questionnaire consists of 16 statements with three aspects: items, media, and effectivity. The questionnaire was proved valid by experts and its estimated reliability score was 0.99. This study proved that the Student is still not ready to use the computer-based assessment, with an average readiness of 60%. In addition, there is no effect of economic level, school grade, and device accessibility on the readiness for using the computer-based assessment. Hence, the treatment of all stockholders is needed to prepare students to use the computer-based assessment.
Item quality analysis using the Rasch model to measure critical thinking ability in the material of the human digestive system of Biology subject in high school
Authors: Prasetya Wanda Agus , Pratama Anggi Tias
Published: September 2023

This study aims to determine the quality of the Biology instrument items on the digestive system material with the Rasch model for analyzing critical thinking skills. The research employed a quantitative descriptive method involving 63 students of senior high schools in Yogyakarta. The data were collected using a critical thinking skills description test and processed using the Rasch model with the Winstep 5.0.3.4 program. The study shows that the overall validity is acceptable. The item validity did not require improvement in items 14, 3, 8, 13, 12, 1, 4, 10, 6, 2, 7, 11, 15, and 9, and required improvement or replaced of item 5 because it did not fit. The analysis result using Cronbach's alpha shows that the overall reliability is very good, and the item reliability is good. Rating scale analysis using partial credit ratings and probability curves shows that respondents need help understanding the five-point Likert scale. The analysis of the item difficulty based on Logit and Wright maps shows that the most difficult item to work on is item 14. Items with moderate categories are items 13, 12, 1, 4, 10, 6, 2, 5, and 7. Items easy to work on are items 11, 15, and 9. The bias results show item 14 gender-biased. The results of the interaction between the item and the person through the ICC plot image show that all items are on the curve of the outfit confidence space and follow the Rasch modeling.
A Mobile App (Concerto) to Empower Hospitalized Patients in a Swiss University Hospital: Development, Design, and Implementation Report
Authors: Dietrich Damien , Bornet dit Vorgeat Helena , Perrin Franck Caroline , Ligier Quentin
Published: September 2023

Background

Patient empowerment can be associated with better health outcomes, especially in the management of chronic diseases. Digital health has the potential to promote patient empowerment.

Objective

Concerto is a mobile app designed to promote patient empowerment in an in-patient setting. This implementation report focuses on the lessons learned during its implementation.

Methods

The app was conceptualized and prototyped during a hackathon. Concerto uses hospital information system (HIS) data to offer the following key functionalities: a care schedule, targeted medical information, practical information, information about the on-duty care team, and a medical round preparation module. Funding was obtained following a feasibility study, and the app was developed and implemented in four pilot divisions of a Swiss University Hospital using institution-owned tablets.

Implementation (Results)

The project lasted for 2 years with effective implementation in the four pilot divisions and was maintained within budget. The induced workload on caregivers impaired project sustainability and warranted a change in our implementation strategy. The presence of a killer function would have facilitated the deployment. Furthermore, our experience is in line with the well-accepted need for both high-quality user training and a suitable selection of superusers. Finally, by presenting HIS data directly to the patient, Concerto highlighted the data that are not fit for purpose and triggered data curation and standardization initiatives.

Conclusions

This implementation report presents a real-world example of designing, developing, and implementing a patient-empowering mobile app in a university hospital in-patient setting with a particular focus on the lessons learned. One limitation of the study is the lack of definition of a “key success” indicator.
Longitudinal Evaluation of an Integrated Post–COVID-19/Long COVID Management Program Consisting of Digital Interventions and Personal Support: Randomized Controlled Trial
Authors: Derksen Christina , Rinn Robin , Gao Lingling , Dahmen Alina , Cordes Cay , Kolb Carina , Becker Petra , Lippke Sonia
Published: September 2023

Background

The postacute COVID-19 syndrome (PACS) can be addressed with multidisciplinary approaches, including professional support and digital interventions.

Objective

This research aimed to test whether patients who received a health care facilitation program including medical internet support from human personal pilots and digital interventions (intervention group [IG] and active control group [ACG]) would experience fewer symptoms and have higher work ability and social participation than an untreated comparison group (CompG). The second objective was to compare the impact of a diagnostic assessment and digital interventions tailored to patients’ personal capacity (IG) with that of only personal support and digital interventions targeting the main symptoms (ACG).

Methods

In total, 1020 patients with PACS were recruited. Using a randomized controlled trial design between the IG and the ACG, as well as propensity score matching to include the CompG, analyses were run with logistic regression and hierarchical-linear models.

Results

Symptoms decreased significantly in all groups over time (βT1-T2=0.13, t549=5.67, P<.001; βT2-T4=0.06, t549=2.83, P=.01), with a main effect of the group (β=–.15, t549=–2.65, P=.01) and a more pronounced effect in the IG and ACG compared to the CompG (between groups: βT1-T2=0.14, t549=4.31, P<.001; βT2-T4=0.14, t549=4.57, P<.001). Work ability and social participation were lower in the CompG, but there was no significant interaction effect. There were no group differences between the IG and the ACG.

Conclusions

Empowerment through personal pilots and digital interventions reduces symptoms but does not increase work ability and social participation. More longitudinal research is needed to evaluate the effects of a diagnostic assessment. Social support and digital interventions should be incorporated to facilitate health care interventions for PACS.

Trial Registration

ClinicalTrials.gov NCT05238415; https://classic.clinicaltrials.gov/ct2/show/NCT05238415.

International Registered Report Identifier (IRRID)

RR2-10.1186/s12879-022-07584-z
Impactos espaciales de la inseguridad y el crecimiento económico sobre la IED en México, 1999-2019
Authors: Andrés-Rosales Roldán , De Jesús Almonte Leobardo , Cruz Marcelo José Nabor
Published: September 2023

La Inversión Extranjera Directa (IED) en México ha contribuido a determinar el crecimiento económico en los estados. A pesar de que el flujo de estas inversiones ha sido positivo, la inseguridad ha limitado la entrada de inversiones en zonas que históricamente habían atraído IED. Los estados que han concentrado mayor inversión del exterior se localizan en la frontera norte y algunos en el centro del país. Mediante el SpVAR cuantificamos las derramas que la inversión e inseguridad han generado en los estados y sobre sus vecinos cercanos, mostramos que el efecto push-in ha sido más importante que el efecto push-out.
Localización de clínicas y hospitales en la jerarquía vial de Ciudad de México
Authors: Galindo Pérez Mateo Carlos , Reyes García Víctor Alfonso , Suárez-Lastra Manuel
Published: September 2023

Un factor decisivo para potenciar la accesibilidad a servicios de salud es considerar la centralidad y evaluar el tipo de vía para localizar unidades médicas. El objetivo de este documento es demostrar la lógica locacional sobre la vialidad de las unidades médicas de tres instituciones de salud: IMSS, ISSSTE y Sedesa en Ciudad de México. A partir del cálculo de cocientes de localización se reconoce la preferencia de localización de clínicas y hospitales sobre ejes viales y avenidas principales. La mayoría de las rutas de transporte público circulan a un máximo de 200 metros de las unidades médicas.
Financial Distress and Audit Report Lags: An Empirical Study in Korea
Authors: Choi Jihwan , Park Hyung Ju
Published: September 2023

This study examines the association between a firm’s financial distress and audit report lags. Through this analysis, we intend to reveal whether auditors consider theclients’ financial distress when performing external audits. This study employs 2,786 firmyear observations from 2011 to 2018. The sample of this study consists of companies listedon the Korea Composite Stock Price Index (KOSPI) and the Korea Securities Dealers Automated Quotation (KOSDAQ). We perform OLS regression analysis to test our hypothesis. The OLS regression analysis is conducted through the SAS and STATA programs.We find that there is a significant and positive association between financial distress andaudit report lags. The audit report lags increase as the likelihood of clients’ financial distress increases. The results indicate that audits take different amounts of audit effort whenauditors consider financial distress as a business risk when they conduct audits. In otherwords, we provide evidence that auditors increase the amount of audit effort when thelikelihood of clients’ financial distress is high. In the absence of studies on how externalauditors respond to audited firms' financial distress, this study analyzes whether externalauditors change their audit efforts by assessing the audited firms' financial distress. Second, the empirical result that external auditors actually follow the guidelines related tobusiness risk and financial distress specified in the Korean Auditing Standards supportsthe effectiveness of the business risk-related regulations specified in the Korean AuditingStandards
Obinutuzumab in Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome in Children
Authors: Dossier Claire , Bonneric Stéphanie , Baudouin Véronique , Kwon Thérésa , Prim Benjamin , Cambier Alexandra , Couderc Anne , Moreau Christelle , Deschenes Georges , Hogan Julien
Published: September 2023

Background

B-cell depletion with rituximab induces sustained remission in children with steroid-dependent or frequently relapsing nephrotic syndrome. However, most patients relapse after B-cell recovery, and some patients do not achieve B-cell depletion. Obinutuzumab is a second-generation anti-CD20 antibody designed to overcome such situations in B-cell malignancies and was recently reported to be safe and effective in other autoimmune diseases affecting the kidneys.

Methods

We retrospectively report 41 children with steroid-dependent or frequently relapsing nephrotic syndrome treated with a single low-dose infusion of obinutuzumab at Robert-Debre Hospital between April 2018 and December 2020. Participants were treated because of rituximab resistance or relapse after rituximab and received a single infusion of 300 mg/1.73 m2 obinutuzumab with cessation of oral immunosuppressors within 2 months.

Results

B-cell depletion was achieved in all participants and lasted a median of 8.3 months (interquartile range, 6.4–11.1), a duration exceeding that for last rituximab treatment. At 12 and 24 months, 92% (38/41) and 68% (28/41) of patients, respectively, were in sustained remission. Mild infusion reactions occurred in five participants (12%) and neutropenia in nine (21%). No significant decrease in IgG level was reported during treatment, and whereas IgM levels decreased in 34 patients (83%), they were normal at last follow-up in 32 (78%).

Conclusions

These results identified low-dose obinituzumab as a promising treatment option in children with steroid-dependent or frequently relapsing nephrotic syndrome, including those resistant to rituximab. The tolerance profile of obinutuzumab was similar to that of rituximab, but hemogram and immunoglobulin levels should be monitored.
Chronic Interstitial Nephritis in Agricultural Communities
Authors: Holliday Michael W. , Majeti Ravikumar Nagavenkata , Sheikh-Hamad David
Published: September 2023

Chronic interstitial nephritis in agricultural communities (CINAC) is an epidemic of kidney disease affecting specific tropical and subtropical regions worldwide and is characterized by progressive CKD in the absence of traditional risk factors, such as hypertension and diabetes. CINAC prevalence is higher among young, male agricultural workers, but it also affects women, children, and nonagricultural workers in affected areas. Biopsies from patients with CINAC across regions commonly demonstrate tubular injury with lysosomal aggregates, tubulointerstitial inflammation, and fibrosis and variable glomerular changes. Each endemic area holds environmental risk factors and patient/genetic milieus, resulting in uncertainty about the cause(s) of the disease. Currently, there is no specific treatment available for CINAC. We highlight survey findings of Houston-based migrant workers with CINAC and draw similarities between kidney injury phenotype of patients with CINAC and mice treated chronically with paraquat, an herbicide used worldwide. We propose potential pathways and mechanisms for kidney injury in patients with CINAC, which may offer clues for potential therapies.
Gender Differences in Secondary School Students’ Achievement in Chemistry in Samburu County, Kenya
Authors: Ekwam Lomonyang , Keraro Fred N. , Ng’eno Joel K.
Published: September 2023

The purpose of this study was to investigate the gender differences in secondary school students’ achievement in chemistry. In addition, the study sought to identify the factors that contribute to gender differences in chemistry achievement to in order to enhance the provision of equal opportunities for the learning of chemistry and all other sciences in general to both boys and girls. Cross-Sectional study design under the descriptive survey research was used. The target population of the study comprised of all the secondary school chemistry students in both public and private secondary schools in Samburu county. The accessible population were all the form three chemistry students in the county. A sample of 286 students was selected from a population of 1,238 using stratified and simple random sampling techniques. Students’ Chemistry Achievement Test (SCAT) and Students’ Gender Interview Schedule (SGIS) were used to collect data. The data collected was analyzed using both descriptive and inferential statistics. The statistics derived included the analysis of percentages, mean, standard deviation, students’ T-Test scores and Chi-Square Test (x2 test) used to establish the relationship between culturally accepted gender roles and achievement in chemistry. The findings show that there was a statistically significant gender difference in chemistry achievement in favour of boys. As a result, boys’ schools performed better than both girls’ and co-educational schools. Boys had a high affinity and interest towards chemistry than girls. Also the culturally accepted gender roles had an effect on chemistry achievement. It is recommended that the Ministry of Education should initiate in-service programmes for teachers in science courses emphasizing on relevant scientific skills to empower teachers to provide learning opportunities that would reduce the gender differences and the effect of cultural factors known to enhance gender differences in the learning and achievement in chemistry. Curriculum developers and policy makers need to develop curriculum materials that would help to reduce the gender gap in learning and achievement.
Dissecting the Association between Quality of Work Life Practices and the Proficiency of Instructors’ Productivity
Authors: Abdelsater Hussein
Published: September 2023

The Quality of Work Life (QWL) is an educational and occupational matter for instructors. This research conducted in Lebanon aimed to determine the influence of the quality of work-life practices and the proficiency of instructors’ productivity. Data was collected from instructors working in private universities. Through a quantitative study, the dimensionality of the measuring instrument was examined. Exploratory and confirmatory phases were applied. The EFA phase followed the factor analysis to assess structure, validity, and reliability. The CFA revealed an adequate model adjustment, with average to excellent adjustment index values. Results validated that practices of quality of work-life influence instructors’ productivity directly. However, these results confirmed that job satisfaction has the most significant effect. The conclusion discussed results and integrated recommendations and avenues for future studies.
ОСОБЕННОСТИ ТЕХНОЛОГИИ ИОННО-ЛУЧЕВОГО НАНЕСЕНИЯ МНОГОСЛОЙНЫХ ОПТИЧЕСКИХ ПОКРЫТИЙ ДЛЯ РЕЗОНАТОРОВ ИНЖЕКЦИОННЫХ ЛАЗЕРОВ
Authors: Фомин А.В. , Филоненко Е.М. , Анашкин Е.А.
Published: September 2023

Работа посвящена созданию технологии получения оптических покрытий для резонаторов инжекционных лазеров на установке ионно-лучевого нанесения. Для требуемых коэффициентов отражения на торцах резонаторов спроектированы оптические покрытия, и отработаны режимы нанесения составляющих их диэлектрических слоев. Отработка режимов нанесения заключалась в определении оптимальных параметров ионного луча, соотношений расходов газа-источника ионов и газа-реагента и температуры подложки. Расчет спектральных характеристик высокоотражающих и просветляющих покрытий, полученных на основании предложенных конструкций и экспериментальных значений коэффициентов преломления диэлектрических слоев, свидетельствует о достижении необходимых коэффициентов отражения на торцах резонаторов инжекционных лазеров.