bluuebunny/crossref_metadata_2025 huggingface dataset:
Laparoscopic versus opengastric surgery for the treatment of pathological T1N0M0 gastric cancer in elderly patients: a matched study
Authors: Pan Haiyan , Li Tao , Huang Zhigang , Yu Haibing , Kong Danli , Ding Yuanlin , Pan Congcong , Jiang Yugang
Published: May 2017

The aim of this study was to compare the outcomes of laparoscopic surgery (LAP) and open gastric surgery (OP) in early gastric cancer patients aged ≥70 years.We conducted a retrospectively analysis among patientswith pathological T1N0M0gastric cancer,who underwent LAP or OP between January 1, 2001 and December 31, 2008. We identified a well-balanced cohort of 2,360 patients (1180 patients in each group). LAP has been shown to offer a superior perioperative results to OP, including lower blood loss, shorter time to oral intake, walk and bowel function recovery, shorter time of hospital stay, and less blood transfusion required. However, the intraoperative and postoperative complications, local recurrence, and metastasis didn’t show statistically significant differences between groups. The 5-year overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were 60.1% vs.63.2%, 80.8% vs. 83.3%, and 87.6% vs. 89.5% in the LAP group and OP group, respectively. The hazard ratios (HR) for OS, DFS, and CSS were 1.09(95% confidence interval [CI]: 0.95–1.25; P = 0.215), 1.03(95% CI: 0.91–1.18; P = 0.636), and 1.07 (95% CI: 0.88–1.30; P = 0.484), respectively, compared LAP group with OP group. In conclusion, LAP is an acceptable alternative to OP in elderly patients with early gastric cancer.
Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies
Authors: Domljanovic Ivana , Carstens Annika , Okholm Anders , Kjems Jørgen , Nielsen Christoffer Tandrup , Heegaard Niels H. H. , Astakhova Kira
Published: May 2017

To date, there are multiple assays developed that detect and quantify antibodies in biofluids. Nevertheless, there is still a lack of simple approaches that specifically detect autoimmune antibodies to double-stranded DNA. Herein we investigate the potential of novel nucleic acid complexes as targets for these antibodies. This is done in a simple, rapid and specific immunofluorescence assay. Specifically, employing 3D nanostructures (DNA origami), we present a new approach in the detection and study of human antibodies to DNA. We demonstrate the detection of anti-DNA antibodies that are characteristic of systemic lupus erythematosus, a chronic autoimmune disease with multiple manifestations. We tested the most potent non-covalent pairs of DNA and fluorescent dyes. Several complexes showed specific recognition of autoimmune antibodies in human samples of lupus patients using a simple one-step immunofluorescence method. This makes the novel assay developed herein a promising tool for research and point-of-care monitoring of anti-DNA antibodies. Using this method, we for the first time experimentally confirm that the disease-specific autoimmune antibodies are sensitive to the 3D structure of nucleic acids and not only to the nucleotide sequence, as was previously thought.
Mechanics of thermally fluctuating membranes
Authors: Los J. H. , Fasolino A. , Katsnelson M. I.
Published: May 2017

Besides having unique electronic properties, graphene is claimed to be the strongest material in nature due to its Young modulus, which is, per atomic layer, much larger than that of steel. This reasoning however does not take into account the peculiar properties of graphene as a thermally fluctuating crystalline membrane, which at finite temperature, lead to a dramatic reduction of the Young modulus for micron-sized graphene samples in comparison with atomic scale values. We show that the standard Föppl-von Karman elasticity theory for thin plates, routinely used for the interpretation of experimental results has to be modified for graphene at room temperature and for micron-sized samples. Based on scaling analysis and atomistic simulation, we investigate the mechanics of graphene under transverse load up to breaking. We determine the limits of applicability of the Föppl-von Karman theory and provide quantitative estimates for the different regimes.
A hybrid organic-inorganic perovskite dataset
Authors: Kim Chiho , Huan Tran Doan , Krishnan Sridevi , Ramprasad Rampi
Published: May 2017

Hybrid organic-inorganic perovskites (HOIPs) have been attracting a great deal of attention due to their versatility of electronic properties and fabrication methods. We prepare a dataset of 1,346 HOIPs, which features 16 organic cations, 3 group-IV cations and 4 halide anions. Using a combination of an atomic structure search method and density functional theory calculations, the optimized structures, the bandgap, the dielectric constant, and the relative energies of the HOIPs are uniformly prepared and validated by comparing with relevant experimental and/or theoretical data. We make the dataset available at Dryad Digital Repository, NoMaD Repository, and Khazana Repository (http://khazana.uconn.edu/), hoping that it could be useful for future data-mining efforts that can explore possible structure-property relationships and phenomenological models. Progressive extension of the dataset is expected as new organic cations become appropriate within the HOIP framework, and as additional properties are calculated for the new compounds found.
Effect of Adding Cerium on Microstructure and Morphology of Ce-Based Inclusions Formed in Low-Carbon Steel
Authors: Adabavazeh Z. , Hwang W. S. , Su Y. H.
Published: May 2017

Intra-granular Acicular Ferrite (IAF), as one of the most well-known desirable microstructure of ferrite with a chaotic crystallographic orientation, can not only refine the microstructure and retard the propagation of cleavage crack but also provide excellent combination of strength and toughness in steel. The effect of adding cerium on microstructure and controlling proper cerium-based inclusions in order to improve properties in low-carbon commercial steel (SS400) were investigated. The type of inclusions can be controlled by changing S/O ratio and Ce content. Without Ce modification, MnS is a dominate inclusion. After adding Ce, the stable inclusion phases change from AlCeO3 to Ce2O2S. The optimum amount of cerium, 0.0235 wt.%, lead in proper grain refinement and formation of cerium oxide, oxy-sulfide and sulfide inclusions. Having a high amount of cerium results in increasing the number of inclusions significantly as a result it cannot be effective enough and the inclusions will act like barriers for others. It is found that the inclusions with a size of about 4∼7 μm can serve as heterogeneous nucleation sites for AF formation. Thermodynamic calculations have been applied to predict the inclusion formation in this molten steel as well, which show a good agreement with experimental one.
Mercury pollution in vegetables, grains and soils from areas surrounding coal-fired power plants
Authors: Li Rui , Wu Han , Ding Jing , Fu Weimin , Gan Lijun , Li Yi
Published: May 2017

Mercury contamination in food can pose serious health risks to consumers and coal-fired power plants have been identified as the major source of mercury emissions. To assess the current state of mercury pollution in food crops grown near coal-fired power plants, we measured the total mercury concentration in vegetables and grain crops collected from farms located near two coal-fired power plants. We found that 79% of vegetable samples and 67% of grain samples exceeded the PTWI’s food safety standards. The mercury concentrations of soil samples were negatively correlated with distances from the studied coal-fired power plants, and the mercury contents in lettuce, amaranth, water spinach, cowpea and rice samples were correlated with the mercury contents in soil samples, respectively. Also, the mercury concentrations in vegetable leaves were much higher than those in roots and the mercury content of vegetable leaves decreased significantly after water rinses. Our calculation suggests that probable weekly intake of mercury for local residents, assuming all of their vegetables and grains are from their own farmland, may exceed the toxicologically tolerable values allowed, and therefore long-term consumptions of these contaminated vegetables and grains may pose serious health risks.
Super-radiating manipulation of a nano-emitter by active toroidal metamaterials
Authors: Li Jie , Zhu Ming-Jie , Wang Ying-Hua , Jin Ren-Chao , Li Jia-Qi , Dong Zheng-Gao
Published: May 2017

The far-field radiation of a single dipolar emitter can be controlled by coupling to toroidal dipole resonance attached to metallic double flat rings, realizing a conversion from non- to super-radiating. The underlying physical mechanism is the hybridization interference of toroidal and electric dipoles under an asymmetric configuration by introducing a radial displacement of the dipolar emitter. By embedding gain medium in the gap spacer between double flat rings, the directional far-field super-radiating power can achieve a tremendous enhancement with a moderate requirement on the gain coefficient, promoting light-matter interaction manipulation.
Correction: Corrigendum: Biomechanics of subcellular structures by non-invasive Brillouin microscopy
Authors: Antonacci Giuseppe , Braakman Sietse
Published: May 2017

Scientific Reports 6: Article number: 37217; published online: 15 November 2016; updated: 09 May 2017 The authors wish to acknowledge other contributors and other sources of funding. The Author Contributions statement should read: G.A. and S.B. contributed to the design of the experiments. G.A. contributed to the development of the microscope.
Correction: Corrigendum: A xandarellid artiopodan from Morocco – a middle Cambrian link between soft-bodied euarthropod communities in North Africa and South China
Authors: Ortega-Hernández Javier , Azizi Abdelfattah , Hearing Thomas W. , Harvey Thomas H. P. , Edgecombe Gregory D. , Hafid Ahmid , El Hariri Khadija
Published: May 2017

Scientific Reports 7: Article number: 42616; published online: 17 February 2017; updated: 09 May 2017 This Article contains errors in Figure 7. The correct Figure 7 appears below as Figure 1 with a corrected Figure legend and additional references:
Correction: Corrigendum: Isolation and characterization of a bacteriophage phiEap-2 infecting multidrug resistant Enterobacter aerogenes
Authors: Li Erna , Wei Xiao , Ma Yanyan , Yin Zhe , Li Huan , Lin Weishi , Wang Xuesong , Li Chao , Shen Zhiqiang , Zhao Ruixiang , Yang Huiying , Jiang Aimin , Yang Wenhui , Yuan Jing , Zhao Xiangna
Published: May 2017

Scientific Reports 6: Article number: 28338; published online: 20 June 2016; updated: 09 May 2017 In the original version of this Article, Wenhui Yang was incorrectly listed as being affiliated with ‘Key Laboratory of Risk Assessment and Control for Environment and Food Safety, Tianjin Institute of Health and Environmental Medicine, Tianjin, 300050, China’.
Sensory integration deficits support a dimensional view of psychosis and are not limited to schizophrenia
Authors: Carter O , Bennett D , Nash T , Arnold S , Brown L , Cai R Y , Allan Z , Dluzniak A , McAnally K , Burr D , Sundram S
Published: May 2017

Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities. The present study assessed patients with a range of psychotic and nonpsychotic disorders and healthy controls on visual contrast detection, visual motion integration, auditory tone detection and auditory tone integration. The sample comprised a total of 249 participants (schizophrenia spectrum disorder n=98; bipolar affective disorder n=35; major depression n=31; other psychiatric conditions n=31; and healthy controls n=54), of whom 178 completed one or more visual task and 71 completed auditory tasks. Compared with healthy controls and nonpsychotic patients, psychotic patients trans-diagnostically were impaired on both visual and auditory integration, but unimpaired in simple visual or auditory detection. Impairment in visual motion integration was correlated with the severity of positive symptoms, and could not be accounted for by a reduction in processing speed, inattention or medication effects. Our results demonstrate that impaired sensory integration is not specific to schizophrenia, as has previously been assumed. Instead, sensory deficits are closely related to the presence of positive symptoms independent of diagnosis. The finding that equivalent integrative sensory processing is impaired in audition is consistent with hypotheses that propose a generalized deficit of neural integration in psychotic disorders.
Differential antibody responses to gliadin-derived indigestible peptides in patients with schizophrenia
Authors: McLean R T , Wilson P , St Clair D , Mustard C J , Wei J
Published: May 2017

Gluten consumption has previously been implicated in the development of schizophrenia while an immunological link between gluten and schizophrenia was established by the detection of circulating antibodies against gliadin, a major component of wheat gluten. Several studies have reported an increase in circulating antibodies against native gliadin molecules that are unlikely to survive degradation in the digestive system. In this study, therefore, we measured plasma immunoglobulin G (IgG) and IgA antibodies against indigestible gliadin-derived peptide antigens using an in-house enzyme-linked immunosorbent assay (ELISA) among 169 patients with schizophrenia and 236 control subjects. We also examined the plasma levels of IgG and IgA antibodies against the mixture of native gliadins using commercially available ELISA kits. The results showed that patients with schizophrenia had the increased levels of plasma IgG against the γ-gliadin-derived fragment, namely AAQ6C, but decreased levels of plasma IgG against the α- and γ3-gliadin-derived antigens, as compared with control subjects. This study also demonstrated a uniform decrease in plasma IgA antibodies against gliadin-derived antigens. There was no significant difference in the levels of plasma antibodies against native gliadins between the patient group and the control group. Of eight gliadin-derived antigens tested, four showed a sensitivity of >20% against the specificity of ⩾95% for detection of their corresponding antibodies in plasma. These four tests may thus have a potential to serve as biomarkers for the identification of schizophrenia subgroups that may need an alternative therapy or precision treatment. Further investigation with clinical trials should be carried out to explore this possibility.
Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity
Authors: González-Vera Juan A. , Bouzada David , Bouclier Céline , Eugenio Vázquez M. , Morris May C.
Published: May 2017

We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb3+] complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosphoaminoacid binding moiety.
Potato protease inhibitor II suppresses postprandial appetite in healthy women: a randomized double-blind placebo-controlled trial
Authors: Zhu Yong , Lasrado Joanne A. , Hu Jiang
Published: May 2017

The effect of potato protease inhibitor II (PI2) on postprandial appetite was examined in a randomized double-blind placebo-controlled cross-over trial involving 44 healthy women.
Pressure-induced insulator-to-metal transitions for enhancing thermoelectric power factor in bismuth telluride-based alloys
Authors: Gaul Andrew , Peng Qing , Singh David J. , Ramanath Ganpati , Borca-Tasciuc Theodorian
Published: May 2017

Straining Bi2−xSbxTe3−ySeyactivates additional highly degenerate electronic bands near the Fermi level, providing over two-fold enhancement in thermoelectric power factor.
Multiscale simulations for understanding the evolution and mechanism of hierarchical peptide self-assembly
Authors: Yuan Chengqian , Li Shukun , Zou Qianli , Ren Ying , Yan Xuehai
Published: May 2017

Multiscale molecular simulations that combine and systematically link several hierarchies can provide insights into the evolution and dynamics of hierarchical peptide self-assembly from the molecular level to the mesoscale.
One-step formulation of nonionic surfactant bicelles (NSBs) by a double-tailed polyglycerol-type nonionic surfactant
Authors: Aramaki Kenji , Iwata Chikahiro , Mata Jitendra , Maehara Tetsuya , Aburano Daisuke , Sakanishi Yuichi , Kitao Kyuhei
Published: May 2017

Bicelles can be formulated by a simple one-step process using a polyglyceryl dialkyl ether that has asymmetric tails.
The water-based synthesis of chemically stable Zr-based MOFs using pyridine-containing ligands and their exceptionally high adsorption capacity for iodine
Authors: Wang Zhe , Huang Ying , Yang Jian , Li Yongsheng , Zhuang Qixin , Gu Jinlou
Published: May 2017

Zr-MOFs with inherent pyridine moieties were synthesized by a water-based approach, and exhibited exceptionally high adsorption capacity for I2.
Metal–organic frameworks constructed from tib and carboxylate acid ligands: selective sensing of nitro explosives and magnetic properties
Authors: Yang Liu , Cao Li , Li Xiao , Qin Chao , Zhao Liang , Shao Kui-Zhan , Su Zhong-Min
Published: May 2017

Four novel metal–organic frameworks have been synthesized under certain conditions. 1 and 2 can be used as fluorescent sensors for small-molecule sensing with high selectivity. Meanwhile, 3 and 4 are both antiferromagnetic substances.
Plasmonic resonance excited dual Z-scheme BiVO4/Ag/Cu2O nanocomposite: synthesis and mechanism for enhanced photocatalytic performance in recalcitrant antibiotic degradation
Authors: Deng Yaocheng , Tang Lin , Zeng Guangming , Feng Chengyang , Dong Haoran , Wang Jiajia , Feng Haopeng , Liu Yani , Zhou Yaoyu , Pang Ya
Published: May 2017

Novel dual Z-scheme BiVO4/Ag/Cu2O nanocomposite was prepared and presented enhanced photocatalytic activity.
Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids
Authors: Awalt Jon Kyle , Lam Raymond , Kellam Barrie , Graham Bim , Scammells Peter J. , Singer Robert D.
Published: May 2017

N-Demethylation of selected N-methylalkaloids using a modified Polonovski reaction can be accomplished employing nanoscale zero-valent iron, nZVI, in isopropanol.
Simple robust estimation of uranium isotope ratios in individual particles from LA-ICP-MS measurements
Authors: Walsh Stephen J. , Dzigal Naida , Chinea-Cano Ernesto , Limbeck Andreas
Published: May 2017

Statistical model diagnostics assess the quality of the ablation run and underscore the validity of the data reduction approach.
Contribution of single particle inductively coupled plasma mass spectrometry and asymmetrical flow field-flow fractionation for the characterization of silver nanosuspensions. Comparison with other sizing techniques
Authors: Motellier S. , Pelissier N. , Mattei J. G.
Published: May 2017

Agreements and discrepancies are pointed out in the comparison between spICP-MS, AF4-MALLS-ICP-MS, and other routine techniques for nanoparticle sizing. Calibration protocols play an important role in analytical result quality.
New sulfonated copoly(triazole imide)s synthesized by a click chemistry reaction with improved oxidative stability
Authors: Singh Asheesh , Ganesh Kumar Anaparthi , Bisoi Soumendu , Banerjee Susanta
Published: May 2017

New sulfonated copoly(triazole imide)s synthesized by a click chemistry reaction with improved oxidative stability.
Olfaction, taste and chemoreception: scientific evidence replaces “Essays in biopoetry”
Authors: Appendino Giovanni , Brönstrup Mark , Kubanek Julia M.
Published: May 2017

Giovanni Appendino, Mark Brönstrup and Julia Kubanek introduce the Natural Product Reports themed issue on ‘Olfaction, taste and chemoreception’.
Intramolecular cascade rearrangements of enynamine derived ketenimines: access to acyclic and cyclic amidines
Authors: Chauhan Dinesh Pratapsinh , Varma Sreejith J. , Gudem Mahesh , Panigrahi Nihar , Singh Khushboo , Hazra Anirban , Talukdar Pinaki
Published: May 2017

Copper-catalyzed reaction of enynamine with sulfonylazide generates a ketenimine intermediate which further undergoes rearrangements to form acyclic and cyclic amidines.
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics
Authors: Bouquet J. , King D. T. , Vadlamani G. , Benzie G. R. , Iorga B. , Ide D. , Adachi I. , Kato A. , Vocadlo D. J. , Mark B. L. , Blériot Y. , Désiré J.
Published: May 2017

Fluorination of the NHCOCH3 moiety of a trihydroxylated azepane-based broad hexosaminidase inhibitor significantly improves its selectivity toward bacterial NagZ.
Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding
Authors: Balazy Milena , Fausto Alejandra , Voskanian Christina , Chavez Bianca , Panesar Harmanpreet , Minehan Thomas G.
Published: May 2017

Compound1d(Kapp= 2.4 × 107M−1), a derivative of the azinomycin B chromophore, strongly associates with DNA by intercalation and major groove binding.
In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction
Authors: Kano Taichi , Homma Chihiro , Maruoka Keiji
Published: May 2017

Mannich reactions of β-dicarbonyls with in situ generated less accessible Boc-imines from aldehydes were achieved.
Large-scale fabrication of polymer ellipsoids with controllable patches via the viscosity-induced deformation of spherical particles
Authors: Tian Lei , Li Xue , Wan Dewei , Ali Zafar , Zhang Qiuyu
Published: May 2017

A simple and controllable strategy to synthesize polymer ellipsoids via the viscosity-induced deformation of spherical particles is proposed.
Controlled radical polymerization of vinyl ketones using visible light
Authors: Lee In-Hwan , Discekici Emre H. , Anastasaki Athina , de Alaniz Javier Read , Hawker Craig J.
Published: May 2017

Herein we report the photoinduced electron transfer–reversible addition–fragmentation chain transfer (PET-RAFT) polymerization of a range of vinyl ketone monomers including methyl, ethyl and phenyl derivatives, using Eosin Y as an organic photoredox catalyst and visible light.
A tetraphenylethylene (TPE)-based supra-amphiphilic organoplatinum(ii) metallacycle and its self-assembly behaviour
Authors: Zheng Wei , Yang Guang , Jiang Shu-Ting , Shao Nannan , Yin Guang-Qiang , Xu Lin , Li Xiaopeng , Chen Guosong , Yang Hai-Bo
Published: May 2017

A tetraphenylethylene (TPE)-based supra-amphiphilic organoplatinum(ii) metallacycle was successfully prepared, which presented biological application in cell imaging.
Structure-controlled CdS(0D, 1D, 2D) embedded onto 2D ZnS porous nanosheets for highly efficient photocatalytic hydrogen generation
Authors: Wang Junmei , Wang Zhijian , Li Li , Chen Jiazang , Zheng Jianfeng , Jia Suping , Zhu Zhenping
Published: May 2017

Modulating the CdS morphology with a 1D structure with high conduction band energy can speed up the electron transfer to Pt sites and increase the photocatalytic hydrogen generation rate from 7.7 to 26 mmol g−1 h−1.
Shedding light on the effective fluorophore structure of high fluorescence quantum yield carbon nanodots
Authors: Wang W. , Wang B. , Embrechts H. , Damm C. , Cadranel A. , Strauss V. , Distaso M. , Hinterberger V. , Guldi D. M. , Peukert Wolfgang
Published: May 2017

The unique luminescence properties of carbon nanodots (CDs) originate from pyridone-like fluorophores bound to carbon core.
Elucidating the 3D structures of Al(iii)–Aβ complexes: a template free strategy based on the pre-organization hypothesis
Authors: Mujika Jon I. , Rodríguez-Guerra Pedregal Jaime , Lopez Xabier , Ugalde Jesus M. , Rodríguez-Santiago Luis , Sodupe Mariona , Maréchal Jean-Didier
Published: May 2017

We present a novel strategy to generate accurate 3D models of Al(iii)–Aβ complexes, which circumvents first principles simulations of metal binding to peptides of Aβ.
Achieving over 10% efficiency in a new acceptor ITTC and its blends with hexafluoroquinoxaline based polymers
Authors: Zhang Zhenzhen , Feng Liuliu , Xu Shutao , Yuan Jun , Zhang Zhi-Guo , Peng Hongjian , Li Yongfang , Zou Yingping
Published: May 2017

We synthesize a new small molecular acceptor, ITTC, and when it is blended with a hexafluoroquinoxaline based polymer donor HFQx-T, the devices deliver an impressive PCE of 10.4%.
The zinc paradigm for metalloneurochemistry
Authors: Barr Chelsea A. , Burdette Shawn C.
Published: May 2017

Neurotransmission and sensory perception are shaped through metal ion–protein interactions in various brain regions. The term "metalloneurochemistry" defines the unique field of bioinorganic chemistry focusing on these processes, and zinc has been the leading target of metalloneurochemists in the almost 15 years since the definition was introduced. Zinc in the hippocampus interacts with receptors that dictate ion flow and neurotransmitter release. Understanding the intricacies of these interactions is crucial to uncovering the role that zinc plays in learning and memory. Based on receptor similarities and zinc-enriched neurons (ZENs) in areas of the brain responsible for sensory perception, such as the olfactory bulb (OB), and dorsal cochlear nucleus (DCN), zinc participates in odor and sound perception. Development and improvement of methods which allow for precise detection and immediate manipulation of zinc ions in neuronal cells and in brain slices will be critical in uncovering the synaptic action of zinc and, more broadly, the bioinorganic chemistry of cognition.
Experimental verification and analysis of analytical model of the shape of bond wire antennas
Authors: Ndip I. , Huhn M. , Brandenburger F. , Ehrhardt C. , Schneider‐Ramelow M. , Reichl H. , Lang K.D. , Henke H.
Published: May 2017

In this Letter, the authors present the experimental verification of an analytical model, which captures the realistic shape of bond wire antennas (BWAs) in dependence on the wire bonding and design parameters. Using the verified model, the impact of the shape of the wires on the performance of BWAs is quantified.
Efficient protocol header recovery algorithm based on iterative decoding between layers
Authors: Fan Liang , Wang Xiaomei , Yang Dongyu , Zheng Yao
Published: May 2017

The iterative header recovery algorithm holds the potential of improving the performance of wireless communication, yet it has to face the challenge of reducing the high complexity. In this study, a method of constructing a candidate set around the observation sequence is proposed to approximate the original code space, by exploiting the channel measurement information. This approximation method narrows the decoding processing scope resulting in an effective estimation of the extrinsic information and a significant reduction of the computational complexity. The extrinsic information in soft form is derived to exploit the soft input and promote header recovery performance. Simulation results and analysis show that the approximation method not only has a comparable performance, but also decreases the computational complexity and the storage consumption, which are of great importance of practical application.
Linear open circuit voltage‐variable step‐size‐incremental conductance strategy‐based hybrid MPPT controller for remote power applications
Authors: Thangavelu Anuradha , Vairakannu Senthilkumar , Parvathyshankar Deivasundari
Published: May 2017

This study presents a novel hybrid maximum power point tracking (HMPPT) controller capable of harvesting maximum power from solar panels in a remote power park which can be used for applications such as outdoor uninterruptible power supply, cellular phone and laptop chargers. The proposed HMPPT controller combines two MPPT methods, namely the linear open‐circuit voltage method and variable step‐size incremental conductance method and it has a simple and robust way of tracking MPP based on the relationship between the solar panel characteristics and load line. A 100 W photovoltaic (PV) generation system with soft switched interleaved flyback (SSIFB) converter is built to implement the proposed HMPPT algorithm. The soft switching of flyback converters in the proposed PV‐SSIFB system is achieved by zero voltage switching–pulse width modulation technique. The steady‐state performance under various constant irradiations and transient characteristics for rapidly varying irradiations and load changes are investigated. The effectiveness of the controller in the recommended circuit is verified by the simulation results and validated using a prototype model. Both simulation and experimental results show several advantages, namely accuracy, high tracking speed, minimum power loss and increased adaptability for a wide range of irradiations and load.
Symmetric hybridised design for a novel step‐up 19‐level inverter
Authors: Barzegarkhoo Reza , Zamiri Elyas , Moradzadeh Majid , Shadabi Hamed
Published: May 2017

Nowadays, reduction in number of dc voltage sources alongside boosting property of the output voltage with reduced circuit components are counted as the most important topological features for the new structures of multilevel voltage source inverters. Considering the above, this study presents a new configuration of such converters which can produce a step‐up 19‐level waveform of the output voltage with a contribution of only two same (symmetric) values of dc voltage sources and 12 power switches. The proposed structure is composed of a switched‐capacitor (SC) and a floating‐capacitor‐based (FCB) cell integrated into two isolated sub‐units that have been series with each other as an hybridised platform. Herein, the relevant involved switches of the SC and FCB sub‐units are modulated on the basis of an hybridised pulse width modulation technique which facilitates a significant degradation in the total power loss dissipation. An appropriate boosting feature with a self‐charge balancing capability of all integrated capacitors, reasonable number of required semiconductor devices, higher efficiency and less complexity are other advantages of the proposed step‐up 19‐level inverter. To verify the precise performance of the proposed topology under different types of loading conditions, apart from the theoretical analysis, several simulation and experimental results will also be presented.
Manipulating a Multicomponent Reaction: A Straightforward Approach to Chromenopyrazole Hybrid Scaffolds
Authors: Neochoritis Constantinos , Kasapidou Paraskevi , Zarganes-Tzitzikas Tryfon , Tsoleridis Constantinos , Stephanidou-Stephanatou Julia
Published: May 2017

An easy access to hybrid bioactive molecules, such as the chromenopyrazoles, is described based on the three-component reactions of 3-formylchromones, arylhydrazines, and acetylenedicarboxylates. By manipulating the reaction, four different scaffolds can be derived in an easy, versatile, and robust fashion. To underscore the potential, generality, and diversity that can be generated, representative libraries of each scaffold were synthesized. Moreover, a comprehensive NMR analysis with full assignment of all 1H and 13C NMR chemical shifts has been performed.
Meningioma with Metastatic Malignant Melanoma: An Unusual Coincidence
Authors: Savant H. , Doshi Anand , Sheikh Zafar , Mahajan Vijay
Published: May 2017

Simultaneous occurrence of meningioma and brain metastasis as two different histopathologically-proven lesions has been often reported in literature, however, to the best of our knowledge, contiguous occurrence of meningioma and malignant melanoma has not been reported previously in literature. A 50-year-old woman presented with features of raised intracranial pressure and left upper motor neuron signs. Imaging findings were suggestive of right frontoparietal and right parietal extra-axial space occupying extra-axial lesions. Patient underwent right frontotemporoparietal craniotomy with excision of both tumors under general anesthesia. Histopathological analysis was suggestive of transitional meningioma (World Health Organization [WHO] grade I) and malignant melanoma (WHO grade IV). Simultaneous presence of two tumors in the brain might be of the same or different histopathology. In such dual tumors, metastasis cases are varied and one source of it may be melanoma of the skin. Hence, dermatological examination can reveal the primary source of tumor in select cases.
Personalberatung: Wanted: Furchtlose, freundliche Personaler
Authors: Gaede Kirsten
Published: May 2017

Personalberater nach Trends in der Klinikbranche zu fragen, scheint müßig. Was sollen sie schon sagen: Vermutlich werden wie immer Mediziner gesucht, und sicherlich auch Geschäftsführer. Unerwartet ist dagegen die Antwort von Andrea Köhn: Ihr Team hat in den vergangenen Monaten mit rund 400 Personalern gesprochen, um acht Leitungspositionen zu besetzen.
Kooperationen mit Ärzten: Partnerschaft unter Korruptionsverdacht
Authors: Piontke Cornelia , Schlaudt Hans-Peter
Published: May 2017

Krankenhäuser sind auf Honorar- und Belegärzte angewiesen. Mit Blick auf die Compliance sind diese Kooperationen allerdings ein Risikobereich. Für eine rechtssichere Partnerschaft ist entscheidend, wie die Verträge gestaltet sind und wie die Zusammenarbeit tatsächlich umgesetzt wird.
Wechselmotivation und Arbeitgeberattraktivität: Was bewegt Führungskräfte in der Pflege?
Authors: Winkler Florian , Krey Christina , Glodde Silvia
Published: May 2017

Die größte Berufsgruppe im Gesundheitswesen steht vor deutlichen Veränderungen: Fachkräftemangel, generalistische Pflegeausbildung, Akademisierung und steigende Anforderungen an die Managementkompetenz sind nur die Spitze des Eisbergs. Was bewegt Pflegeführungskräfte, die in diesem Setting agieren? Und wie kann man gutes Personal halten?
Charité: Land Berlin kauft privatisierte FM-Tochter zurück
Authors: Doelfs Guntram
Published: May 2017

Die Charité hat 2016 ein Plus von 3,8 Millionen Euro erwirtschaftet, das sechste Plus in Folge. Allerdings bereitet die im Jahr 2006 privatisierte Facility-Management-Tochter CFM Sorgen. Auch weil diese wegen ihrer niedrigeren Löhne im Dauerclinch mit Verdi liegt, will der Berliner Senat die Firma nun wieder zurückkaufen. Das könnte der Charité Personalmehrkosten von bis zu 28 Millionen Euro bescheren.
Entscheidungsunterstützung für Geschäftsführer: Wie die Simulation der Zukunft Kliniken für die digitale Revolution wappnet
Authors: Maier Björn
Published: May 2017

Die Entscheidungsfindung in Krankenhäusern beruht immer noch stark auf vergangenheitsorientierten und sehr leistungsbezogenen Daten. Unser Gastautor Björn Maier beschreibt, wie Kliniken ihr Controlling in Zukunft ausrichten müssen.
Gesundheitstelematik: Langsamer Aufschwung
Authors: Staemmler Martin
Published: May 2017

Spätestens mit dem Inkrafttreten des E-Health-Gesetzes vor 15 Monaten hat das deutsche Gesundheitswesen den ersten Schritt ins digitale Zeitalter vollzogen. Experte Martin Staemmler beleuchtet für kma den aktuellen Umsetzungsstand für wichtige Anwendungsfelder in der Gesundheitstelematik – und zeigt, wo weiter Handlungsbedarf besteht.
Terminologiesysteme: Wenn der Herzinfarktpatient Antibiotika bekommt
Authors: Neumann Norbert
Published: May 2017

Je weiter die Digitalisierung voranschreitet, desto mehr wird die medizinische Fachsprache und ihre Mehrdeutigkeit zum Problem. „Wir sollten uns sputen, Terminologien im Gesundheitswesen zu etablieren“, fordert deshalb kma-Gastautor Norbert Neumann.
Spontaneous Healing of a Pediatric Scaphoid Proximal Pole Fracture Nonunion
Authors: Riley Nicholas , McNab Ian , Rupani Neal
Published: May 2017

Background Scaphoid fractures in the pediatric population are rare. The majority of nondisplaced fractures tend to unite; however, there is an increased risk of nonunion in proximal pole fractures. Limited evidence exists in their outcomes, owing to the scarcity of the fracture pattern.

Case Description A 13-year-old boy who presented late after developing a traumatic proximal pole scaphoid fracture developed nonunion. He was treated conservatively owing to it being asymptomatic and developed union at 18 months.

Literature Review No previous case of proximal pole pediatric scaphoid fractures with established nonunion that has developed union with conservative management has been described.

Clinical Relevance The authors highlight a unique case of an established proximal pole scaphoid nonunion in a child progressing to union with nonoperative intervention. Owing to its rarity and difficulty in obtaining research, we recommend consideration of nonoperative management of asymptomatic nondisplaced proximal pole fractures in children.
The Influence of the Type of Surgical Thread and Suture in the Open Carpal Tunnel Syndrome Surgery
Authors: Magalhães Marcelo José Silva , Cruz Beatriz Xavier , Santos Fabrício Conceição dos , Oliveira Isabella Mendes de , Sousa João Pedro Saraiva , Guimarães Thaís de Oliveira , Lopes Thiago Antunes , Hoffmann Ernesto José
Published: May 2017

Carpal tunnel syndrome (CTS) is the result of compression and/or traction of the median nerve in the carpal tunnel. It is the most frequent compressive neuropathy of the upper limbs and it is usually idiopathic. Diagnosis is essentially clinical, defined by symptoms and provocative tests. Decompression of the median nerve by section of the transverse carpus ligament is the treatment of choice, but the lack of consensus on the type of suture and surgical thread to be used in the open carpal tunnel decompression surgery justifies the importance of evaluating the comparative results of existing studies, aiming to describe the influence of different types of sutures and surgical threads to guide the professionals about the most appropriate conduct. This is a systematic review of the international and national literature. Four studies comparing the influence of surgical threads and one study evaluating the influence of the type of suture were found. From the comparative studies, it was observed that there is advantage in the use of nonabsorbable suture due to the lower occurrence of inflammation and postoperative wound complications. When using Donatti sutures, wound edge inversion is less likely to occur compared with single individual sutures, but they are also related to longer postoperative pain.
Luminal Obstruction of Double J Stents Due to Encrustation Depends on Indwelling Time: A Pilot Study
Authors: Kadihasanoglu Mustafa , Kilciler Mete , Atahan Ozcan
Published: May 2017

Double J (DJ) stents serve as a therapeutic option to relieve obstruction. However, incrustation can be an important cause of dysfunction of these stents. We investigated the relationship between incrustation of DJ stents and indwelling time using a grading system for luminal occlusion.

The medical records of 42 patients with urolithiasis related to DJ stent incrustation were retrospectively reviewed. All polyurethane DJ stents were examined for severity of incrustation with a grading system based on the occlusion of stent lumen. For the level of grades 3 groups of patients were compared: group 1 included 14 patients whose stents were removed a month after insertion; group 2 included 16 patients whose stents were removed 45 days after insertion; group 3 included 12 patients whose stents were removed 3 months after insertion.

The incrustation of 42 DJ stents was graded from 1 to 3 depending on the occlusion of the DJ stent. Mean age of patients was 39.6±6.71 years and median indwelling time was 50 days. The groups were similar regarding age, sex, and side of DJ stent. In comparison, the grade of incrustation in group 3 was higher than the grades in group 1 and group 2 (p=0.001).

Incrustation is one of the most important complications of DJ stents, and was related to indwelling time. Therefore, close follow-up and frequent DJ stent changes are very important in patients with urolithiasis.
Isoliert hochfrequente vestibuläre Läsion bei Patienten mit chronischen Schwindelbeschwerden
Authors: Hülse Roland , Hülse Manfred , Hörmann Karl , Hölzl Matthias , Birk Richard , Wenzel Angela
Published: May 2017

In der vorliegenden Studie wurde bei 72 Patienten, die zum Zeitpunkt der Untersuchung bereits seit mehr als 3 Monaten unter Schwindelbeschwerden litten und bei denen bisher keine peripher-vestibuläre Genese der Beschwerden mittels bithermischer und rotatorischer Testung nachgewiesen werden konnte, der hochfrequente Anteil des vestibulo-okulären Reflexbogens mittels des Videokopfimpulstestes (vKIT) analysiert.

Hierzu wurde der vKIT bei 72 Patienten retrospektiv ausgewertet und mit den Ergebnissen von Rotatorik und Kalorik verglichen. Analysiert wurde beim vKIT das Auftreten von Catch-Up Sakkaden sowie der Gain bzw. Gainseparation.

10 Patienten (n=10; 13,8%) zeigten einen pathologischen veränderten hVOR-Bogen bei hochfrequenter Überprüfung mittels vKIT. Der mittlere Gain der restlichen Gruppe (n=62, 86,2%) zeigte sich mit 0,85 bei horizontaler Testung nach rechts sowie mit 0,87 bei 60 ms bei horizontaler Testung nach links normwertig.

Bei Patienten mit chronischen Schwindelbeschwerden, die in der klassischen vestibulären Routinediagnostik mit Kalorik und Rotatorik keine Pathologien aufweisen, sollte eine komplette rezeptor- und frequenzspezifische Diagnostik durchgeführt werden, um eine isoliertes hochfrequentes Schädigungsmuster des vestibulookulären Reflexbogens objektivieren und dokumentieren zu können. Bei einer unklaren Begutachtungssituation sollte daher diese erweiterte Schwindeldiagnostik nicht mehr fehlen.
The challenge of transformative experiences for advance directives: predicting a future with Alzheimer’s disease
Authors: Boerstler Kyle
Published: May 2017

Some of the experiences that are possible in life are not relatable to others, nor can one learn about them in other ways, at least not in the sense of what it is like to have lived the experience. L.A. Paul calls these kinds of experiences transformative experiences. This article will incorporate Paul’s concept into an argument that undermines the moral authority of advance directives in situations where the instructions stated in the directive are in direct conflict with the contemporary interests of a patient who suffers from Alzheimer’s disease. Though the conclusion of this paper will be similar to many others in the literature, namely that advance directives should not in all cases be the final authority on how to respect a patient’s autonomy, this article will argue for this kind of a thesis in a unique way because it will emphasize the importance of that which no one can know. The argument contends that the lived experience of Alzheimer’s disease is a transformative experience, such that one cannot weigh the subjective value of what it is like to be a person with Alzheimer’s disease in the relevant way to properly assess the possible future interests and preferences when creating an advance directive. This article is published as part of a collection on self-knowledge in and outside of illness.
Probabilistic inverse design for self-assembling materials
Authors: Jadrich R. B. , Lindquist B. A. , Truskett T. M.
Published: May 2017

One emerging approach for the fabrication of complex architectures on the nanoscale is to utilize particles customized to intrinsically self-assemble into a desired structure. Inverse methods of statistical mechanics have proven particularly effective for the discovery of interparticle interactions suitable for this aim. Here we evaluate the generality and robustness of a recently introduced inverse design strategy [B. A. Lindquist et al., J. Chem. Phys. 145, 111101 (2016)] by applying this simulation-based machine learning method to optimize for interparticle interactions that self-assemble particles into a variety of complex microstructures as follows: cluster fluids, porous mesophases, and crystalline lattices. Using the method, we discover isotropic pair interactions that lead to the self-assembly of each of the desired morphologies, including several types of potentials that were not previously understood to be capable of stabilizing such systems. One such pair potential led to the assembly of the highly asymmetric truncated trihexagonal lattice and another produced a fluid containing spherical voids, or pores, of designed size via purely repulsive interactions. Through these examples, we demonstrate several advantages inherent to this particular design approach including the use of a parametrized functional form for the optimized interparticle interactions, the ability to constrain the range of said parameters, and compatibility of the inverse design strategy with a variety of simulation protocols (e.g., positional restraints).
Real-time detection of S(1D2) photofragments produced from the 1B2(1Σu+) state of CS2 by vacuum ultraviolet photoelectron imaging using 133 nm probe pulses
Authors: Horio Takuya , Spesyvtsev Roman , Furumido Yu , Suzuki Toshinori
Published: May 2017

Ultrafast photodissociation dynamics from the 1B2(1Σu+) state of CS2 are studied by time-resolved photoelectron imaging using the fourth (4ω, 198 nm) and sixth (6ω, 133 nm) harmonics of a femtosecond Ti:sapphire laser. The 1B2 state of CS2 was prepared with the 4ω pulses, and subsequent dynamics were probed using the 6ω vacuum ultraviolet (VUV) pulses. The VUV pulses enabled real-time detection of S(1D2) photofragments, produced via CS2*(1B2(1Σu+)) → CS(X 1Σ+) + S(1D2). The photoionization signal of dissociating CS2*(1B2(1Σu+)) molecules starts to decrease at about 100 fs, while the S(1D2) fragments appear with a finite (ca. 400 fs) delay time after the pump pulse. Also discussed is the configuration interaction of the 1B2(1Σu+) state based on relative photoionization cross-sections to different cationic states.
Derivation of the Navier slip and slip length for viscous flows over a rough boundary
Authors: Jiménez Bolaños Silvia , Vernescu Bogdan
Published: May 2017

In this paper, we derive the Navier slip boundary condition for flows over a rough surface, by combining homogenization methods and boundary layer techniques. The Navier slip condition is derived as the effective boundary condition, in the limit as the roughness becomes small; it is the first order corrector to the no-slip condition on the limiting smooth surface. Using this method, we are simultaneously able to provide a formula for computing the slip length for various geometries. The paper provides a theoretical justification for the observed slip in micro- or nanofluidics, as well as a computational tool. Computations done using FreeFem++ agree with experimental data.
Domain dynamics in stoichiometric lithium tantalate revealed by wet etching and on-line second harmonic generation
Authors: Kianirad H. , Zukauskas A. , Canalias C. , Laurell F.
Published: May 2017

The effect of chemical etching on the stability of domains in periodically poled stoichiometric lithium tantalate is studied by on-line second harmonic generation and microscopy. It is found that wet etching directly after poling leads to domain-wall movement, resulting in back-switching or domain merging. Head-to-head domains tend to backswitch, while tail-to-tail domains merge. For samples where the domain structure stabilized for longer time, no domain motion is observed when etched.