bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodology and positionality: A process of weaving the individual to the collective
Authors: Worchel Jessica
Published: January 2025

Identifying a methodology can be daunting to an emerging researcher, but the key is to start from your place of strength – knowing who you are, your readiness to engage with an in-depth study, and what story is needing to be brought to light for the benefit of society. “Positionality refers to the stance or positioning of the researcher in relation to the social and political context of the study—the community, the organization or the participant group” (Coghlan & Brydon-Miller, 2014, p. 628), and it should guide the entire process of the research. The key to good research is relationships, and before we can have relationality, we must have positionality. Positionality brings purpose which dictates the tikanga (correct procedures) that align to that purpose. Positionality determines relationality, which determines your research objectives, and then your methodology begins to take shape. This article shares considerations I took as a Pākehā researcher when choosing a methodological framework that weaves together Indigenous and Western methodologies to honour and uphold the mana (sense of self-efficacy, pride, power) of the people and places where the research was conducted, meet the guidelines of academic study, and represent my positionality and passions.
A Review of Knowledge-Based Interventions for Mental Health Self-Management
Authors: Okuboyejo Sena
Published: January 2025

Mental health disorders have affected people's everyday lives globally, showing rapid growth. Effective detection, diagnosis, and treatment of MSDs can occur by utilizing increasingly substantial amounts of available health data from diverse sources. However, there are many challenges in developing effective treatment models for this condition. The challenges are further complicated by the volume, heterogeneity, interoperability, propagation, and complexity of data, especially with the emergence of big data. Knowledge management and knowledge-based systems have significantly impacted healthcare quality and delivery, especially patient self-management. In this work, we review knowledge-based applications for mental health self-management. The research efforts are synthesized, discussing shortcomings and future research directions.
Mitos y conocimiento sobre el suicidio adolescente
Authors: Ormart Elizabeth , Stagno Valentina , Díaz Cano Laura
Published: January 2025

El artículo presenta un estudio descriptivo de corte transversal sobre las creencias con respecto al suicidio, considerado por la OMS (2021) como una de las principales causas de muerte entre los 15 y 29 años. Con el objetivo de identificar el conocimiento sobre ciertos mitos que circulan acerca del suicidio, se difundió una encuesta para medir su presencia. La muestra es de 205 personas, entre los 13 y los 59 años, residentes en Argentina; un 27,8% autopercibidos con el género masculino, 69,3%, femenino, y 2.9%, no binario. En general, el conocimiento de los mitos en torno al suicidio corresponde al “nivel bueno”; el género femenino demuestra mayor nivel de conocimiento, y los grupos etarios “jóvenes” y “adultos jóvenes” puntuaron mejor que los demás. Se concluye que es fundamental implementar talleres educativos y de divulgación al respecto para atender la problemática e idear tácticas de prevención, intervención y postvención del suicidio.
Breve introduccion a ciencia abierta
Authors: Laguna-Camacho Antonio
Published: January 2025

En esta exposición se trata el movimiento de ciencia abierta en respuesta a la crisis en replicación. En este sentido, se describen algunas prácticas cuestionables que elevan la tasa de resultados falsos positivos. Además, se presentan algunas iniciativas de ciencia abierta que buscan reformar la transparencia, el rigor y la reproducibilidad de la investigación. Para finalizar, se plantea que la ciencia abierta se está adoptando rápidamente y que favorece la calidad del saber científico.
Jak przeczytać drzewo? Literackie i pozaliterackie znaczenia roślin
Authors: Kraj Łukasz
Published: January 2025

In recent years there has been a growing interest in the representation of plants in literature. This article explores the modalities of the transfer of meaning of physical plants to its literary counterparts. Drawing on neurobotany and cultural studies, the paper analyzes a number of real and metaphorical herbaria to demonstrate that the meaning of plants in literature is a product of both biosemiotic and discursive processes. The analyses are rounded off with a survey of two complementary models of the plant--oriented ecocriticism, Patrícia Vieira’s phytographia and John C. Ryan’s phytocriticism, arguing that the text-inscribed plant meaning is always co-produced by the author and the reader, while the multiplicity of forms it can take is potentially infinite.
Militaryzacja natury w powieści Siergieja Liebiediewa Ludzie sierpnia
Authors: Ubertowska Aleksandra
Published: January 2025

This is a critical analysis of the war discourse in a two books, a volume of philoso-phical essays and a a work of fiction. They are Frames of War: When Is Life Grievable? (2009) by Judith Butler and People of August (2016), a novel by the contemporary Russian writer Sergei Lebedev. Both authors see war not as an discrete event on a timeline, but as a network of events that accumulate in time. This is especially evident in Lebediev's palimpsest of Russia's 20th-century history. The article examines closely the spatial ele-ments of the novel as well as its take on the relationship between human history (Russian totalitarianism) and nature.
Poetycki agon w głębi mózgu O wierszu Nadchodzi noc Stanisława Korab Brzozowskiego
Authors: Milan Rafał
Published: January 2025

This article contains a reading of the poem ‘Nadchodzi noc’ [The night is coming] by Stanisław Korab-Brzozowski in the context of his evolving poetic biography, primarily with regard to the gradual spiritualization of his idea of the ‘naked soul’. While the brain occupies the central position in in Korab-Brzozowski’s poetic landscape, it is not merely a material locus of consciousness. The crucial element of the chain of events in ‘Nad-chodzi noc’ is located inside the brain, the dark area where, paradoxically, the physio-logical trigger goes into spiritual overdrive (the dying sunrays “go up in a fire and glow, / Which puts the night to flight / Forever.) The unexpected ending of a matter-of-fact description can be an indication of Korab-Brzozowski’s joining Stanisław Przybyszewski in his 1890s Berlin battles with plain naturalism (die bloße Schilderung). Yet at the same the young contributor of the magazine Życie [Life] entered into subtle polemic with his literary master. Later, as secretary of the flagship modernist magazine Chimera, Korab- -Brzozowski kept up a shifting balance, i.e. a poetic agon, between Przybyszewski’s antinaturalism and the latest developments in empiricist physiology (Angelo Mosso and Cesare Lombroso among others).
Transcultural Practices and Educational Inclusion: Design of a Neurodidactic Model of Sustainable Teacher Training
Authors: Camargo Claudia de Barros , Flores Jose Ignacio Rivas , López Rocio Quijano
Published: January 2025

Objective: The objective of this study is to investigate transculturality, educational inclusion, neurodidactics, teacher training and sustainability in the context of modern education.
 
Theoretical Framework: This article presents the main concepts and theories that support research on transculturality, inclusion and neuropedagogy.
 
Method: Using a non-experimental, descriptive, explanatory and correlational design, 653 individuals were surveyed, including 132 practicing teachers and 521 university students of Primary Education. A validated Likert-type questionnaire was used to assess perceptions and attitudes towards these dimensions. Exploratory factor analysis and correlation tests revealed strong interrelations between the dimensions studied. A regression analysis identified neurodidactics as the most significant predictor of teacher training, followed by educational inclusion, sustainability and transculturality.
 
Results and Discussion: The results suggest the need for a holistic approach to teacher training that integrates these key aspects. The design of a sustainable neurodidactic model of teacher training that incorporates transculturality and educational inclusion is proposed. This model would involve a curriculum based on neuroscience, the development of intercultural competences, inclusive pedagogical strategies, principles of sustainability, reflective practice, experiential learning and continuous professional development.
 
Research Implications: The implementation of this model would require collaboration between educational institutions, policy makers and educators, as well as mechanisms for evaluation and continuous improvement.
 
Originality/Value: The relevance and value of this research are evident in that it can change the vision on transculturalism and teaching practice.
Cuidar de quem cuida: o desafio da atualidade no Brasil
Authors: Rabelo de Matos Silva Arruda Camila
Published: January 2025

Ao longo dos anos, o papel do idoso na sociedade vem mudando consideravelmente, a população está envelhecendo e aumentando a expectativa de vida no decorrer das últimas décadas. Com o envelhecimento, houve a necessidade de cuidados direcionados às necessidades dos idosos. A Lei nº 10741/03 estabeleceu o Estatuto do Idoso, em um naquele momento no qual houve uma preocupação do legislador em assegurar o direito de envelhecer com dignidade. A política de cuidado foi estabelecida pela Lei nº 15069/24, lei esta que busca a proteção da pessoa do cuidador, tanto trabalhista, quanto previdenciária e social. Este artigo visa realizar uma análise da necessidade de cuidar de quem cuida, ou seja, a fim de avaliar de que forma a sociedade vem tratando o cuidador do idoso e a importância deste para uma vida de qualidade do assistido, enfatizando, inclusive, políticas públicas que estão sendo elaboradas para os cuidadores de idosos.
Patterns and determinants of Neighborhoods Quality of informal Communities in Metropolitan Lagos using Statistical Techniques
Authors: Akinde Jubril
Published: January 2025

Metropolitan Lagos in Nigeria is renowned for its numerous informal communities, characterized by a lack of official recognition and residents' land ownership rights, leading to substandard housing and inadequate neighborhood services. These areas, though often contested by migrants and indigenous populations, are integral to the city. Despite previous studies focusing on formal city conditions, informal communities in Lagos remain underexplored. This study aimed to describe the socio-demographic characteristics, housing quality, and neighborhood conditions of these communities. Primary data from 1,600 respondents across fifteen informal communities were collected through structured questionnaires. Analysis included descriptive statistics, factor analysis, ANOVA, generalized linear regression, and spatial autocorrelation techniques. Findings revealed one-room apartments with wooden features as predominant housing types. Principal component analysis summarized 21 residential quality indicators into eight components, with low residential and neighborhood quality but high locational quality indexes. ANOVA indicated significant variations in quality indexes across communities, while spatial autocorrelation analysis showed no significant clustering. Regression analysis highlighted the influence of gender, ethnicity, income, occupation, and homeownership on residential and neighborhood quality. The study concluded by advocating for improved dwellings, increased public services, and collaborative efforts for the renewal of Lagos' informal communities.
First Marriage Rate, 2023
Authors: Bankey Natalie
Published: January 2025

Since 2008, the refined marriage rate in the U.S. has declined, dropping from 37.5 marriages per 1,000 unmarried males and females to 33.6 marriages per 1,000 in 2023 (Westrick-Payne, 2024). Over the same period cohabitation rates have continued to rise, reflecting a broader trend among younger adults to postpone marriage, with first marriages increasingly occurring at later ages (Brown et al., 2022; Manning & Loo, 2024). This shift positions marriage as a capstone experience, underscoring the importance of distinguishing first marriage rates from remarriage rates. Using the latest data from the American Community Survey, we examine the first marriage rate among males and females 18 and older. This Family Profile is an update to previous profiles on the first marriage rate (FP-23-17, FP-21-09, FP-20-01, FP-18-14, FP-16-18, FP-14-08, FP-11-12, and FP-10-05).
Remarriage Rate, 2023
Authors: Bankey Natalie
Published: January 2025

Refined marriage rates in the U.S. have seen a 54% decrease since the 1990’s, with only 31.3 per 1,000 unmarried women married in 2022 (Loo, 2024). The refined divorce rate increased steadily throughout much of the 20th century until it peaked around 1980 and since then has been slowly declining (Loo, 2024). At the same time, recent decades have been marked by a substantial decrease in remarriages, with only 24.1 per 1,000 previously married U.S. adults entering remarriage in 2022 (Loo, 2024). This Family Profile provides an update of remarriage rate estimates for males and females aged 18 and older in 2023 using the latest release of the U.S. Census Bureau’s American Community Survey (ACS) provided by IPUMS-USA. This profile is an update to previous profiles on the remarriage rate (FP-15-08; FP-18-16; FP-19-17; FP-21-18; & FP-23-19).
#STRONGISTHENEWSEXY: Performatividades pornográficas y visualidades de resistencia en la cultura del fitness de Instagram
Authors: Radrigán Valeria
Published: January 2025

El presente artículo realiza un análisis crítico sobre el fenómeno de pornificación de la cultura del fitness en Instagram. Se pone una especial atención en las performatividades pornográficas, que en esta red social aparecen, asociadas a una espectacularización del vigor y a una exposición del cuerpo en esfuerzo y con signos visuales de fortaleza. La hipótesis central apuesta a que en ellas se despliegan emblemas estéticos de un capital sexual idealizado que contribuyen a una estandarización hegemónica de lo erótico. Paralelamente, dicho proceso da cuenta de la exaltación de valores que son promovidos por la sociedad neoliberal y el sistema hetero-cis normativo (control, productividad, disciplina, entre otros). En la medida en que Instagram, como metadispositivo de visibilidad de la sociedad red, asiste en la masificación de estas estéticas y principios, la exposición de visualidades de resistencia se vuelve compleja. Al respecto, se propone un foco en la “mujer forzuda” como ícono representacional en el que aparecen una serie de tensiones y paradojas sobre la mirada y la configuración del deseo en la web 3.0.
“Desplazamientos: desbordes disciplinarios para la transformación de las convenciones escénicas en la investigación-creación en danza”
Authors: Andrade Proaño Ruth Valeria
Published: January 2025

Este estudio examina la puesta en escena Desplazamientos, realizada en 2020 y 2021 en la Compañía Nacional de Danza del Ecuador (CNDE); la cual fue concebida como una iniciativa de investigación que fusiona la experimentación artística y la reflexión académica. En la primera fase de la investigación, se desarrolla un laboratorio experimental que ensambla varias tecnologías corporales: el Kundalini Yoga, la danza y la performance. A ello, se integran herramientas reflexivas etnográficas y grupos focales, donde se discuten los temas que surgen antes o después de cada ensayo. En la segunda fase de la investigación, se recolectan datos mediante entrevistas abiertas realizadas a cada uno de los participantes. En los resultados se discuten las transformaciones de los procesos disciplinares de la danza dentro de la institución. Además, se analizan las prácticas y acuerdos como metodología para la creación colectiva; misma que se expresa en la escritura de este artículo que incluye la voz directa de los cinco participantes. Se profundiza en la reflexión sobre el ensamblaje de las técnicas corporales y etnográficas. Finalmente, se caracterizan los desplazamientos de las convenciones escénicas y la experimentación dentro del dispositivo coreográfico en relación con los espectadores.
Lo digital como continuum del archivo análogo: El caso del documental Locas Mujeres (2010) y cómo Gabriela Mistral vive a través de la preservación análoga y digital.
Authors: Rayo Calderón Catalina Esmeralda
Published: January 2025

Este es un estudio sobre cómo el archivo es manejado y entendido en su concepto más tradicional (amurallado, físico, único) y cómo puede existir en un medio que muta constantemente como lo es el digital. La pregunta: ¿es posible hablar de archivo en el medio digital siendo éste un medio efímero por naturaleza? Abre análisis y propone la idea de que el medio digital si es capaz de conservar y preservar, pero solo bajo ciertos criterios que demandan un cambio en el entendimiento del archivo.   
Enfocado en el documental de Elena Wood, Locas Mujeres (2010), el estudio propone un continumm de preservación y conservación que va desde el terreno análogo, físico y material; hacia al archivo fílmico en el digital. El filme representa cómo Doris Dana conservó, durante 50años, material original y literario de Gabriela Mistral, desde sus notas y cuadernos, hasta fotografías, audios, recortes de diarios, etc. El resultado fue una habitación completa de información, y se ve la responsabilidad de conservarlo y preservarlo por la sobrina de Doris Dana, Doris Atkinson. Wood, decide entonces hacer un filme sobre el archivo de Mistral, que da como resultado el archivo del archivo.
Entrelazando Disciplinas: un Enfoque Interdisciplinario sobre la Economía Creativa y su Influencia en los Estudios Culturales
Authors: Cruchett Pastrana Paulina Alejandra
Published: January 2025

El presente artículo explora la relación entre la economía creativa y los estudios culturales desde una perspectiva interdisciplinaria. Su argumento se basa en la necesidad de utilizar métodos interdisciplinarios para abordar problemas complejos en la sociedad actual, donde la cultura emerge de diversas prácticas humanas como el arte, la política y la religión. Se subraya la importancia de la antropología cultural para entender la vinculación entre la economía creativa y la cultura, destacando cómo la multi, inter y transdisciplinariedad mejora la comprensión de la dinámica del sector cultural y fomenta el diálogo entre disciplinas que normalmente no interactúan.  El artículo se enfoca en cómo la creatividad y la innovación en la economía creativa contribuyen al valor económico y cultural, promoviendo un desarrollo económico sostenible, considerando aspectos territoriales y sociales, y cómo este sector puede ser un puente hacia la equidad y la superación de desigualdades. Concluye enfatizando el potencial de la economía creativa y los estudios culturales para enriquecer el diálogo académico y contribuir al entendimiento del impacto cultural y económico de la creatividad y la innovación. Además, se destaca la relevancia de este enfoque interdisciplinario para el desarrollo de políticas públicas que fortalezcan la colaboración entre comunidades locales, el sector académico y los sectores público y privado, promoviendo un desarrollo integral y sostenible.
Entrevista a Milena Gallardo Villegas y Felipe Palma Irarrázaval: prácticas en torno a la investigación y creación
Authors: Becar Ayala Guillermo
Published: January 2025

Prácticas en torno a la investigación y creación:
Hola, soy Guillermo Becar Ayala[1], director de la Escuela de Artes Escénicas y Audiovisuales, e integrante del equipo editor de la Revista Actos de la Universidad Academia de Humanismo Cristiano. Les doy la bienvenida a todas, todos y todes.
 
[1] Doctorando en Artes Integradas, Universidad de Playa Ancha. Magister en Investigación y Creación Artística Contemporánea, Universidad Mayor. Licenciado en Danza, Universidad Academia de Humanismo Cristiano. Licenciado en Educación, Universidad Academia de Humanismo Cristiano.
Supplying the Kostroma militia with horses in 1812
Authors: Kondrat'ev Nikolai Vladimirovich
Published: January 2025

The purpose of the work is to clarify the data of historiographic research and to present new facts about the supply of horses for the Kostroma militia during the Patriotic War of 1812. The sources include documents from the funds of the Russian State Military Historical Archive, the Russian State Historical Archive and the State Archive of the Kostroma Region. The documentary data are compared with the texts of K.A. Voensky, V.R. Apukhtin, N.N. Vinogradov and others. An important component of the information in the sources is the mechanisms for recruiting the equestrian staff of the main and reserve militias, the calculation of combat and draft horses, and the issues of handing over horses at the end of military operations. The documents allow us to assess the military-economic potential of the Kostroma province in the selected aspect. The results obtained allow us to assess and interpret indicators such as: general information on horse supplies, the ratio of quantitative indicators and the requirements of military articles, etc. In the future, it will be possible to use information about the provision of the Kostroma militia with horses to compare it with other militias of the 3rd district. The following conclusions were made based on the results of the study: firstly, despite significant irreparable losses in the regional archive, a comparison of documents and historiographical studies allows us to present a very interesting aspect of the history of the Kostroma militia of 1812; secondly, documentary materials reveal previously unknown aspects of the topic, for example, the supply of horses not only for the main, but also for the reserve militia.
PHYLOGENETIC ANALYSIS AS A STEP OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR PARTIAL AGONIST DESIGN
Authors:   Belarusian State Medical University, Minsk, Akunevich A.A. , Khrustalev V.V.
Published: January 2025

In the EGF structure of the Bovinae subfamily and the Cervidae family, there are changes in the Cys position in the Nand C-terminal fragments. The C-terminal fragment (Glu40–Trp49) is the most promising region for introducing an amino acid substitution during the design of its mutant form with reduced agonistic activity, since this region is characterized by the least variability
during the process of evolution.
ANALYSIS OF STENOTROPHOMONAS MALTOPHILIA ANTIPHAGE DEFENSE SYSTEMS *
Authors:   Novosibirsk State University, Jdeed G. ,   Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Morozova V.V. , Tikunova N.V.
Published: January 2025

Stenotrophomonas maltophilia exhibits intrinsic high-level of resistance to a variety of antibiotics and is an opportunistic
pathogen, the World Health Organization lists it as one of the leading drug-resistant pathogens in hospitals worldwide. With the rise
of antibiotic resistance, bacteriophages appear to be the promising alternative.
UV LIGHT EXPOSURE IN AMPHIBIAN GENOMES: CC:GG>TT:AA
Authors:   Immanuel Kant Baltic Federal University, Kaliningrad, Lobanova V.V. , Mikhaylova A.G. , Popadin K.Y.
Published: January 2025

In this work, we show that the nuclear and mitochondrial genomes of amphibians exhibit increased frequencies of CC:GG>TT:AA dinucleotide mutations compared to other groups of vertebrates. We suggest that this may be due to exposure to ultraviolet
radiation during the sensitive period of embryonic development.
COMPARATIVE ANALYSIS OF AMINO ACID SEQUENCES OF S8 PEPTIDASE FROM BACILLUS SPP.
Authors:   Institute for Biological Instrumentation RAS, Pushchino, Milovidov G.D. , Tikhomirova T.S. , Nemashkalov V.A.
Published: January 2025

Serine proteases are widely used in various fields, including the food industry and medicine. Modern enzymes have high activity and broad substrate specificity, the characteristics of which are influenced by both external conditions and intramolecular features.
This study examines the amino acid sequences of proteases belonging to the S8 family from Bacillus spp. to evaluate the intramolecular
determinants affecting their enzymatic properties.
The not-so-sweet side of mango: Mango allergy
Authors: Edpuganti Sudeep , Gaikwad Jui Rajendra , Maliyil Binu Thomas , Koshy Rowyna Reji , Potdar Rhea , Latheef Shifna , Korrapati Naga Harika
Published: January 2025

Mango (Mangifera indica), from the Anacardiaceae family, originates from Asia and has grown globally. Despite its wide nutritional benefits, mango can induce allergic processes in some individuals. Mango allergy occurs from the body’s immune response to various proteins found in the mango fruit, peel, stem, sap, or tree. Oral allergy syndrome (burning sensation and swelling in the mouth), to severe conditions, including anaphylaxis is included in the spectrum of symptoms observed. Contact dermatitis, a delayed hypersensitivity reaction that manifests as rash, pruritus, and blisters, is also observed in patients after direct contact with mango or exposure to related allergens from the Anacardiaceae family, such as poison ivy or oak. This narrative review aims at reviewing the cutaneous manifestations of mango allergy, examining the allergenic profiles of affected individuals, cross-reactivity with other allergens, diagnostic methods, and shed light on the importance of recognizing mango allergy in clinical practice, despite its relative rarity.
Pheochromocytoma Masquerading as Acute Coronary Syndrome and Takotsubo Cardiomyopathy: A Diagnostic Dilemma in the Elderly
Authors: Mahorkar Ajinkya Vijay , Mahorkar Virag Uday , Vidhale Avanti , Donkalwar Amol
Published: January 2025

This case delineates the intricate diagnostic challenges encountered in a 70-year-old woman presenting with chest tightness and severe shortness of breath, initially suggestive of acute coronary syndrome and Takotsubo cardiomyopathy. Despite inconclusive findings on emergency cardiac catheterization, subsequent evaluation unveiled an underlying pheochromocytoma. The patient’s journey from an initial misdiagnosis to the identification of the adrenal mass, successful medical and surgical management, and stable 2-year follow-up highlights the importance of considering rare etiologies in the elderly population.
A clinical study on identification of factors affecting spontaneous closure of postoperative enterocutaneous fistula
Authors: Nukala Srinivasa Rao , Nalla Sai Sudha
Published: January 2025

Objectives

To analyze various biochemical and pathological abnormalities in patients presenting with postoperative enterocutaneous fistula. To determine different factors among these which have a negative impact on spontaneous closure of enterocutaneous fistula. To identify the benefit of timely non-operative interventions by improving the modifiable factors in reducing mortality and morbidity.

Material and Methods

This study is a retrospective analysis conducted in the Department of General Surgery at a tertiary care center. The study included a population of 28 patients and spanned a duration of 21 months, from November 2022 to July 2024. Patients with postoperative enterocutaneous fistula at the center were included, while those with inflammatory bowel disease or on high doses of steroids for other causes were excluded. The collected data were tabulated and analyzed using the Chi-square test of independence, with the significance level set at 0.05.

Results

Significant difference is seen that by correcting modifiable factors, success rate is increased in the spontaneous closure of EC fistulas.

Conclusion

We have to note the modifiable and non modifiable factors and timely intervene to attain spontaneous closure of EC fistulas.
Comparison of two methods of analyzing sales data in the Rossmann store chain
Authors: Shatrov A.V. , Levin M.N.
Published: January 2025

This paper compares two sales forecasting methods based on statistics from the European Rossmann retail chain. The method of multiple linear regression (MultipleLinearRegression – MLR) and the modified random forest method (randomForest) were chosen as comparison methods. The Python development environment is used as a calculation tool. Preliminary processing of the database by types of stores, time intervals of the network, and the state of consumer demand, depending on various factors, allowed us to form the target function of Sales volume. A modified formulation of the problem of the random forest method is discussed in the context of the formation of an ensemble of decision trees. This is achieved by training the Random Forest algorithm on a training sample and then averaging over the ensemble. Based on the calculation results, it is concluded that the random forest model is advantageous based on the values of the criteria R2 (coefficient of determination) and RMSE (mean square error).

В данной работе производится сравнение двух методов прогнозирования продаж по данным статистики европейской торговой сети Rossmann. В качестве методов сравнения выбраны метод множественной линейной регрессии (MultipleLinearRegression – MLR) и модифицированный метод случайного леса (RandomForest). В качестве инструментальной базы расчетов используется среда разработки Python. Предварительная обработка базы данных по типам магазинов, временным интервалам работы сети, состоянию спроса потребителей в зависимости от различных факторов позволила сформировать целевую функцию объема продаж Sales. Обсуждается модифицированная постановка задачи метода случайного леса в контексте формирования ансамбля деревьев решений. Это достигаетс путем обучения алгоритма Random Forest по обучающей выборке и последующего осреднения по ансамбля. По результатам расчета сделан вывод о преимуществе модели случайного леса на основании значений критериев R; (коэффициент детерминации) и RMSE (средняя квадратичная ошибка).
دور ممارسة الريادة الاستراتيجية في التحول نحو المنظمات الذكية: دراسة ميدانية على شركات تكنولوجيا المعلومات الفلسطينية
Authors: أبو غبن نضال فاروق , بكري إبراهيم صبحي , أبو غبن أحمد فاروق
Published: January 2025

هدفت الدراسة للكشف عن طبيعة العلاقة بين ممارسة الريادة الاستراتيجية  والتحول نحو المنظمات الذكية، وبيان أثر ممارسة الريادة الاستراتيجية  في التحول نحو المنظمات الذكية، تكون مجتمع الدراسة المكون من العاملين في الوظائف الإشرافية من مدراء دوائر ورؤساء وحدات وأقسام شركات تكنولوجيا المعلومات والبالغ عددها (62) شركة، وقد خلصت الدراسة إلى العديد من النتائج وهي مستوى ممارسة الريادة الاستراتيجية  في شركات تكنولوجيا المعلومات الفلسطينية جاء بدرجة مرتفعة وبوزن نسبي بلغ (75.3%)، بينما مستوى توافر المنظمات الذكية في شركات تكنولوجيا المعلومات الفلسطينية جاء بدرجة مرتفعة وبوزن نسبي بلغ (73%)، تبين وجود علاقة طردية قوية ذات دلالة إحصائية عند مستوى دلالة (α≤ 0.05) بين ممارسة الريادة الاستراتيجية  والتحول نحو المنظمات الذكية بمعامل ارتباط بلغ (0.890)، وكان من أهم توصيات الدراسة زيادة الاهتمام بتعزيز جميع أبعاد الريادة الاستراتيجية  في شركات تكنولوجيا المعلومات من خلال تطوير ثقافة الريادة الاستراتيجية  لديها، وتدريب العاملين على معايير ونظم ومتطلبات المنظمات الذكية، وتوفير أحدث الأجهزة والتقنيات اللازمة لإنجاز العمل في الشركات.
Thiyl Chemistry: Cysteine-Catalyzed Maleate Isomerization via Aqueous Thiyl Radical Processes
Authors: Kosaka Satoru , Kurebayashi Kentaro , Yamato Naoki , Tanaka Hiroshi , Haruta Naoki , Yamamoto Masanori
Published: January 2025

Enzymatic systems efficiently catalyze the E/Z isomerization of C=C double bonds by thiol-based cysteine residues, while artificial reactions utilizing thiol-based molecules have remained stoichiometric, not catalytic. Herein, we report a catalytic isomerization of maleate to fumarate under mild temperatures using molecular catalysts based on cysteine and its analogs, activated via chemical or photochemical radical processes. Kinetic analysis and density functional theory (DFT) study support an aqueous thiyl radical-catalyzed reaction. The reaction exhibits first-order dependence on the reactant concentration, zeroth-order dependence on the thiol molecule concentration, and first-order with respect to the radical initiator concentration. The catalytic turnover number of 2,500 and initial catalytic turnover frequency of 1.1 s‒1 have been achieved on a small scale in the presence of thiyl radicals, while the gram-scale synthesis is also achieved by the aqueous thiyl catalysis. Chemical “mutational” studies reveal the importance of both the thiol unit and the intramolecular adjacent groups for efficient catalysis.
Structural Order of Mg-Stabilized Amorphous Calcium Carbonate and Its Associated Phase Transformation
Authors: Li Shu Li , Tsao Chieh , Yang Sheng-Yu , Chan Jerry Chun Chung
Published: January 2025

Biominerals formed by marine organisms exhibit intricate structures and support a remarkable range of functionalities. Recent advances in our understanding of biomineralization highlight the pivotal role of magnesium-stabilized amorphous calcium carbonate (Mg-ACC) as a transient precursor in the formation of calcareous biominerals. This feature article summarizes recent in vitro studies of Mg-ACC, illustrating the concepts of particle attachment, secondary nucleation, domain segregation, and mesocrystal formation. Some conceptual issues associated with the ongoing debate between classical nucleation theory and non-classical nucleation theory are discussed. We suggest that solid-state NMR measurements of the van Vleck second moment provide a stringent test for any proposed atomic model of Mg-ACC. The coordination environment of Mg2+ ions and the significance of bicarbonate ions in Mg-ACC are discussed. The diffusion of Mg2+ ions within the calcitic lattice of high-Mg calcite offers a mechanistic insight into the 'dolomite problem'. The fusion of neighboring high-Mg calcite spherulites highlights their potential role as versatile building blocks for calcareous biomineral skeletal frameworks.
Fluorescein Diacetate (FDA) Should Not Be Used to Study Human Carboxylesterase 2 (CES2) in Complex Biological Systems Without Validation
Authors: Karns Carolyn J. , Singh Anchal , Walk Makenzie R. , Adusah Emmanuel , Pearson Alyssa M. , Beck Michael W.
Published: January 2025

Human Carboxylesterase 2 (CES2) is a key xenobiotic metabolism enzyme responsible for the hydrolysis of various drugs. Due to its importance in drug metabolism and its potential as a cancer biomarker, there is a need for reliable and accessible tools to study CES2 activity. Fluorescein Diacetate (FDA) is a commercially available fluorogenic compound that has been employed to study CES2 activity in various systems, including purified enzymes, microsomes, and tissues. Studies carried out in vitro have shown FDA prefers hydrolysis by CES2 over closely related CES1. However, the specificity of FDA for CES2 over CES1 and other hydrolases in complex biological systems has not been rigorously evaluated. In this study, we aimed to complete the characterization of FDA as a chemical tool for studying CES2 in complex biological systems and determine if FDA could be used to study CES2 activity in live cells by combining computational, biochemical, and live cell imaging experiments. Our results indicate that FDA is not suitable for studying CES2 in biological systems where other hydrolases are present like the HepG2 cell line. We advise caution when using FDA to study CES2 and emphasize that rigorous validation is necessary to ensure that chemical tools used in complex biological systems specifically report on the intended molecular target in each experimental context.
Fabricating Elastic Molecular Crystals with Enhanced Mechanical Durability through Molecular Engineering
Authors: Lin Hui-Yao , Li Le , Hou Jia-Wang , Tong Fei , Qu Da-Hui
Published: January 2025

The exploration of elastic organic molecular crystals has significant implications for modulating the mechanical properties of crystalline materials and their practical applications. However, existing research has largely concentrated on the packing regulation of planar molecules, imposing inherent constraints on achievable mechanical properties. Herein, one flexible molecular crystal constructed by purely covalent non-planar twisted conformation with enhanced elastic properties demonstrates unprecedented mechanical capabilities including extensive bending, weight-lifting capacity of 4500 times its mass, and so on. Notably, slender and anisotropic crystals show considerable promise for waveguides and birefringence optical components including sufficiently low optical loss coefficients in the near-infrared region and birefringence coefficient (Δn) comparable to commercial ionic crystals. This work provides innovative strategies for designing flexible crystals and advances the practical frontiers of functionalized crystalline materials.
Palladium-catalyzed enantioselective and stereospecific assembly of axially chiral alkylidenecyclobutanes via N-tosylhydrazone-based carbene couplings
Authors: Ning Xiaoqin , Zhao Tonglin , Zhu Yulei , Liu Bo , Yan Xufei , Xia Ying
Published: January 2025

Synthesis of axially chiral alkylidenecyclobutanes exists sustained challenges by virtue of the compatibility of an efficient asymmetric catalytic system and the meticulous retention of its inherent strained ring structure. We herein disclose an enantioselective carbene cross-coupling reaction of cyclobutanecarbaldehyde-derived N‑tosylhydrazones with organohalides enabled by a combination of palladium catalysis and the modified sulfinamide phosphine ligand (Sadphos). This reaction proof the concept that axial chirality can be constructed on a strained metal carbene intermediate precisely through a sequential process of enantio-determined migratory insertion and β-H elimination. A variety of alkylidenecyclobutanes with heteroatom-substituted stereocenter, tertiary carbon stereocenter, and all-carbon quaternary stereocenter for particular, can be synthesized collectively with excellent yields and high enantioselectivities. Both the two enantiomers can be obtained via selecting the corresponding either cis or trans hydrazone substrates in a stereospecific manner. The synthetic applications of this asymmetric carbene coupling reaction are further demonstrated by the access of enantioenriched free amine by hydrolysis smoothly (99% ee) and the downstream transformations to reach versatile nitrogen-containing heterocycles without any enantiopurity erosion (99% ee).
Theoretical Calculation of Paternó-Büchi reaction between methanal and (2,2-dimethyl-1,3-dioxan-5-ylidene)methanamine in twisted-boat conformation
Authors: Fan Ka Wa
Published: January 2025

This paper is investigated the Paternó-Büchi reaction between methanal and (2,2-dimethyl-1,3-dioxan-5-ylidene)methanamine. The conformer is twisted boat dominant and hence affect the stereochemistry of the product.
Mechanistic insight into the light absorption and charge carrier separation in photoelectrochemical performance of oxygen-doped g-C3N4 and oxygen-vacancy-enriched Mn3O4 nanocomposites
Authors: Zandy Elahe , Bakhtiari Alborz , Madaah Hosseini Hamid Reza
Published: January 2025

With the increasing awareness of the universal need to access clean and renewable energy resources, semiconductor photoelectrocatalysis has emerged as an efficient way to utilize light photons and produce hydrogen. Among different materials used for photoelectrocatalysis, graphitic carbon nitride (g-C3N4) is a promising photoelectrode; but possesses some drawbacks. Also, most researchers are focused on the anodic application of g-C3N4-based materials; while its cathodic performance has remained less investigated. In the present study, a g-C3N4-based nanocomposite made of oxygen-doped g-C3N4 nanosheets, and oxygen-vacancy-containing Mn3O4 nanoparticles with a size range of 20-30 nm was synthesized as photocathode through a facile method and carefully characterized. The internal electric field in the interface enhanced the charge carrier separation compared to both g-C3N4 and oxygen-doped g-C3N4, with an impressive cathodic photocurrent density of the resulting nanocomposite (-5.28 mA.cm-²) higher than those of g-C3N4 (-2.51 mA.cm-²) and oxygen-doped g-C3N4 (-5.05 mA.cm-²) at -1 V vs. Ag/AgCl at pH=7. The bandgap of the oxygen-doped g-C3N4, oxygen-vacancy-enriched Mn3O4, and the resulting nanocomposite were approximately 1.5 eV, 1.4 eV, and 1.6 eV, respectively, and the light absorption ranges for the materials were clearly expanded to the visible region. The specific surface area of the nanocomposite was obtained by BET analysis to be 224.65 m2.g-1, representing a remarkable rise in comparison with oxygen-doped graphitic carbon nitride, contributing to the high photoelectrochemical performance of the nanocomposite electrode. In this platform, the oxygen-vacancy-enriched Mn3O4 also serves as an effective co-catalyst, eliminating the need to use precious materials such as platinum particles.
The prognostic significance of FOXP3 expression in patients with metastatic HER2-positive breast cancer
Authors: Vynnychenko O.I. , Moskalenko Y.V. , Moskalenko R.A.
Published: January 2025

Background. The effectiveness of targeted therapy in patients with HER2+ breast cancer largely depends on the tumor microenvironment. Regulatory T-lymphocytes (FOXP3+) negatively regulate immune responses and are mostly considered a factor of unfavorable prognosis. Breast cancer is a heterogeneous disease with unique biological properties for each molecular subtype. The impact of regulatory T cells on the prognosis of HER2+ breast cancer is controversial.

Purpose – to evaluate the prognostic significance of regulatory T cells in patients with metastatic HER2+ breast cancer.

Materials and Methods. The study included 78 patients with HER2+ breast cancer who were treated at the Sumy Regional Clinical Oncology Center from 2014 to 2024. Data on clinical and pathological characteristics of patients were taken from the primary medical documentation. Immunohistochemistry was performed for all samples of tumor tissue. Regulatory T lymphocytes were visualized using antibodies against FOXP3. Pearson test, One-way ANOVA, Kaplan–Meier method, and logarithmic test were used for statistical analysis. The Local Ethics Committee of the Sumy Regional Clinical Oncology Center approved the study.

Results. The mean age of patients with low and high Foxp3 expression was 53.1 ± 1.74 and 57.3 ± 1.64, respectively. Among patients with high Foxp3 expression, there was a high proportion of women younger than 50 years (p = 0.0423) and estrogen-negative breast cancer (χ2 = 8.4080, p = 0.023). Other clinicopathological characteristics of the patients, such as the location of the primary tumor, histopathological diagnosis, the tumor grades, visceral and non-visceral metastases, and the Ki67 proliferation index, did not show an association with Foxp3 expression. Median progression-free survival was 12.9 months and 15.5 months for patients with low and high Foxp3 expression, respectively (Log-rank p = 0,0001). Median overall survival was 21.6 months and 46.9 months for patients with low and high Foxp3 expression, respectively (Log-rank p = 0,0001).

Conclusions. In patients with metastatic HER2+ breast cancer, high Foxp3 expression is associated with better progression-free and overall survival. Among those with high FOXP3 expression, women under 50 years and with estrogen-negative breast cancer are more prevalent.
ECOLOGICAL AND BIOLOGICAL CHARACTERISTICS AND ASSESSMENT OF THE CURRENT STATE OF THE SPECIES HYLOTELEPHIUM EWERSII (LEDEB.) H. OHBA AND PHEDIMUS HYBRIDUS (L.) ‘T HART. IN THE FLORA OF THE KASTEK GORGE OF THE ILE ALATAU
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Kobylina Tatyana , Tynybekov Bekzat , Musina Maral , Koibassova Laura , Boribay Elmira , Kurmanbay Ussen , Umirbayeva Zoya , Ashirova Zhadyra
Published: January 2025

The article is devoted to the study of the current state of populations of the species Hylotelephium ewersii (Ledeb.) H. Ohba (formerly Sedum ewersii Ledeb.) and Phedimus hybridus (L.) ‘t Hart (also known as Sedum hybridum L. and Aizopsis hybrida (L.) Grulich) in the floristic composition of the coe-nopopulations of these species in the Ile Alatau. The article presents a study and analysis of the biology of the populations of H. ewersii and P. hybridus in the Kastek Gorge of the Ile Alatau, the diversity of their life forms, and ecological reactions in specific ecological-cenotic conditions. Seasonal rhythms of development of H. ewersii and P. hybridus showed their stability and high adaptability to the conditions of the landscape mountain zone of the Ile Alatau. The studies made it possible to identify the adaptations of natural cenopopulations of H. ewersii and P. hybridus to long-term, sustainable existence in condi-tions of a sharply continental climate and to assess their current state. The article presents a taxonomic, ecological, and geographical analysis of the flora of the populations of H. ewersii and P. hybridus. The studied species H. ewersii and P. hybridus have a life form of herbaceous succulent-leafy terrestrial-creeping polycarpics with a rosette-less sympodial model of shoot formation, where, according to the position of the renewal buds, the studied species belong to the chamaephyte biomorph
THE IMPACT OF MEDIA COVERAGE ON THE COURSE OF CRIMINAL PROCEEDINGS AND THE RIGHTS OF PARTICIPANTS
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Muratova A.Zh. , Saktaganova I.S. , Saktaganova A.B. , Үessenaliyev A.Y. , Tokhanova R.
Published: January 2025

This article investigates the impact of media coverage on criminal trials and their participants, with particular attention paid to digitalization and social networks as sources of coverage. The purpose of the study is to analyze both legal and social aspects of interactions between media coverage and judicial system and make recommendations to minimize its negative influence.
This work draws from a content analysis of media publications, comparative legal approach, and study of Kazakh and international judicial practice. The results indicated that excessive media coverage threatens presumption of innocence, compromises judicial independence, and induces psychological pressure among participants. As part of the contribution made, practical recommendations on media regulation were provided including standardization between media outlets and courts as well as offering practical advice to increase transparency and fairness during court proceedings.