bluuebunny/crossref_metadata_2025 huggingface dataset:
Invasive Mole With Impending Uterine Rupture : A Case Report
Authors: Muhammad Syamel
Published: February 2023

Gestational  Trophoblastic  Disease  (GTD)  is an abnormal placenta, composed of a spectrum of premalignant to malignant disorders. In Indonesia, GTD incidence is particularly challenging to estimate, since not all cases will be reported or recognized. It classified into hydatidose mole and gestational trophoblastic neoplasia (GTN). One of those clinicopathological classification of GTN is malignant invasive mole. It is likely to be the cause of increased maternal mortality in Indonesia if the disease is not well diagnosed and treated.We reported the case, a 28 years old woman who had a invasive mole with impending uterine rupture. She had a pervaginam bleeding symptoms since 3 weeks after post curetase due to hydatidose mole indication. She also had multiple abortus history.
ENDODONTIA GUIADA: TECNOLOGIA APLICADA NA RESOLUÇÃO DE TRATAMENTOS DE CANAIS CALCIFICADOS
Authors: Oliveira Douglas Heberlê , Bello Mariana de Carlo , Buligon Mônica Pagliarini , Marin Janice Almerinda , Marquezan Patricia Kolling , Guerim Pedro Henrique Fortes , Marquezan Flávia Kolling
Published: February 2023

As calcificações pulpares provocam alterações morfológicas no interior dos canais radiculares que dificultam o tratamento endodôntico. Para solucionar essa dificuldade, a ferramenta Endoguide ou Endodontia Guiada foi desenvolvida para a resolução de casos complexos. Esta pesquisa objetivou descrever as aplicações da ferramenta Endoguide no tratamento de canais calcificados na endodontia. Todas as buscas foram realizadas por um único pesquisador na base de dados PubMed/MEDLINE e busca manual utilizando os descritores “Endodontics”, “Digital”, “Cone beam”, “Guided”. Foram considerados elegíveis os artigos publicados entre 2010 e 2022 e excluídos os estudos cuja publicação não foi obtida na íntegra e ainda aqueles em que os resultados não apresentaram embasamento teórico e prático suficientes para que pudessem ser incluídos no trabalho. Após as buscas, foram encontrados 47 artigos, selecionados inicialmente pelo título e resumos, excluindo as duplicatas. Ao final, a leitura completa e coleta de dados foi realizada em 6 artigos. As informações relevantes dos artigos selecionados foram transcritas em forma de quadro para sumarizar os achados. A endodontia guiada pode ser uma excelente alternativa para tratamentos de casos complexos, necessitando um investimento financeiro mínimo no consultório, pois os equipamentos de captura de imagem, planejamento virtual e de guias podem ser realizados em laboratórios capacitados. Assim, concluímos que o emprego da Endoguide como ferramenta no tratamento de canais calcificados se mostrou bem-sucedido e sua utilização não requer um conhecimento amplo, podendo ser usada por profissionais menos experientes.
Computer visual syndrome in medical students in virtual education of a Peruvian university during 2021
Authors: Meneses Castañeda Rosario Mercedes , Ramos Rodriguez Sergio Luis , Molfino Jaramillo Chiara del Carmen , Sánchez Miraval Ely Luisa , Stein Montoro David Francisco , Chávez Rodríguez Lourdes Guissel
Published: February 2023

Introduction: During virtual classes in the context of COVID-19, students were exposed to digital screens for many hours, so they could present computer vision syndrome. Objective: To determine the frecuency of computer vision syndrome in sixth-year students of the Faculty of Human Medicine of the Ricardo Palma University in the context of virtual education due to COVID-19 during the period October - November 2021. Results: Most of the students were young adults (54%) and female (60%). The frequency of computer visual syndrome was 93%, it occurred in 94% of women and 90% of men. Most of the students reported having myopia (44%) and astigmatism (22%). Regarding visual symptoms, the students mainly presented tearing (7.9%), itching (7.6%), and headache (7.6%). Conclusions: In the present study, a high frequency of computer visual syndrome was found in medical students who took virtual classes.
Important advances in regenerative medicine. A vision to the future of ophthalmology
Authors: Hernández Rafael Iván , Borobio Guede Eduardo Alan , Suárez Egóavil Catherine , De La Cruz Vargas Jhony A.
Published: February 2023

The treatment of corneal lesions continues to be a topic of great interest. However, despite the development of new technologies and due to the slow evolution and uncertain healing of corneal lesions, they still represent a public health problem since patients can be affected for life, affecting the family and the health system due to the costly and uncertain response to treatment. For this reason, the need arises to seek therapeutic alternatives to treat these patients.
Management of ectopically placed and impacted canine based on their position: A case series
Authors: Behera Swabhiman , Pyne Ananya , Mahawar Nisha , Tandon Ragni
Published: February 2023

The maxillary canine, also known as the cornerstone of the dentition, plays a key role in esthetic and function. During orthodontic treatment of an impacted maxillary canine patient, thorough investigation is required for treatment planning. Precise biomechanics and controlled traction are the keys to success in these cases. This case series highlights the diagnosis, treatment planning, and technique required for management of impacted canines in three different anatomical positions.
The gaps in undergraduate medical education due to the ongoing pandemic: An experience from a private medical college in Kerala
Authors: RAFI ABOOBACKER MOHAMED , NAIR PADMAKUMAR KRISHNANKUTTY , KUTTICHIRA PRAVEENLAL
Published: February 2023

The Covid-19 pandemic affected undergraduate medical education worldwide. By March 2020, colleges in India had to close following a national lockdown. Most of the colleges including ours started using e-platforms. Our earlier studies highlighted concern for lack of patient examination in clinical settings and successes of the online teaching programmes were limited to didactic teaching. The year 2020 also was the year in which the National Medical Commission (NMC) introduced a competency-based system, which was new to all stakeholders. We assessed the impact of Covid-19 on the ongoing teaching pattern in our institute. Actual coverage of theory classes and practical/clinical teaching sessions were gathered from departments across all years of undergraduate medical education and the gap percentage was calculated against the NMC/ Medical Council of India requirements. The gap percentage was calculated as missing classes divided by required classes multiplied by hundred. The heads of departments were consulted, and details of theory, practical and clinical classes taken for each batch before and after lockdown were gathered using a questionnaire. These were compared against the mandated teaching by the NMC guideline for theory, practical and clinics. The results showed a gap ranging from 2% to 83% for theory classes, the least being in anatomy and the highest being in medicine. As there were no practical or clinical sessions during the lockdown, the gap was zero. Various challenges were faced due to online medical education. There was a dilemma over choosing the type of training that would produce adequate numbers with low quality or a delayed training but of assured quality. Various solutions including suspending the ongoing course and converting it to short-term skill training sessions to deal with pandemic care and strategies to improve online teaching were considered.
Non-traditional tools for predicting coronary artery disease
Authors: KHURANA RISHABH , YADAV ANURAG , BUXI T.B.S. , RAWAT KISHAN SINGH , GHUMAN SAMARJIT S.
Published: February 2023

Background

The traditional coronary calcium score (CCS) is a time-tested tool for the evaluation of coronary atherosclerosis and predictor of future cardiovascular events. Non-traditional tools can also have a value in predicting and detecting subclinical coronary artery disease (CAD).

Methods

We studied the role of CCS, the traditional CAD risk predictor, and the less-recognized, non-traditional risk factors, i.e. epicardial fat volume (EFV) and thoracic extracoronary calcium (ECC), to assess the degree of subclinical CAD. In this cross-sectional observational study, we included 950 Indian patients (suspected to have CAD). Coronary computed tomography angiography was performed. Estimation of CCS, EFV and thoracic ECC was done.

Results

A CCS of 0 was seen in 583 patients (61.4%). Of these, 492 patients had normal coronary angiogram but 91 patients had CAD. The median values of EFV were statistically significantly higher in the ‘CAD present and CCS 0’ group compared to the ‘CAD absent and CCS 0’ group (p<0.001). The presence of thoracic ECC involving at least a single site was seen in only 6 of these 91 patients. When both EFV and CCS were considered together for the detection of CAD, the sensitivity and negative predictive value (NPV) were improved compared to either of these in isolation. When ECC was taken together with CCS and EFV, no further improvement in sensitivity or NPV was observed.

Conclusion

The combined use of traditional CCS along with non-traditional EFV may guide us in better profiling cardiovascular risk and supplement the various traditional cardiovascular risk factors/scores.
Opioid: Plenitude versus pittance
Authors: MOHANTI BIDHU KALYAN
Published: February 2023

The opioid crisis in the USA and in other developed countries can potentially affect low- and middle-income countries (LMICs). The licit medical use of opioids has two sides. The USA and high-income countries maintain abundant supply for medical prescription. Between 1990 and 2010, the use of opioids for cancer pain relief was overtaken by a dramatic rise in the opioid prescriptions for non-cancer acute or chronic pain. The surge led to the opioid epidemic, recognized as social catastrophe in the USA, Canada and in some countries in Europe. From 2016, the medical community, health policy regulators and law-makers have taken actions to tackle this opioid crisis. On the other side, formulary deficiency and low opioid availability exists for three-fourths of the global population living in LMICs. Physicians and nurses in Asia and Africa engaged in cancer pain relief and palliative care face a constant paucity of opioids. Millions of patients in LMICs, suffering from life-modifying cancer pain, do not have access to morphine and other essential opioids, due to restrictive opioid policies. Attention will be needed to improve opioid availability in large parts of the world, even though the opioid crisis has led to control the licit medical use in the USA.
MANAGEABLE HEALTH RISKS OF THE PRIMORSKY KRAI POPULATION
Authors: Изергина Е.В. , Лозовская С.А.
Published: February 2023

Первичная профилактика заболеваний, особенно системы кровообращения, всегда считается наиболее эффективным методом лечения. При своевременной коррекции нарушений обмена веществ возможно снизить заболеваемость на 30-40%, инвалидность- до 50%, до 70 % – смертность. В Приморском крае болезни системы кровообращения за последние 5 лет (2016-2020гг) являются ведущей причиной общей смертности населения (около 50% случаев). Отмечен активный рост показателей этой патологии среди населения таких городов, как Арсеньев, Дальнереченск, Лесозаводск и формирование новых очагов в городах: Дальнегорск, Уссурийск, Спасск-Дальний. Проведен анализ предотвратимых рисков, влияющих на развитие болезней системы кровообращения населения в различных районах Приморского края. В группу предотвратимых факторов, отмеченных у населения на территориях с высоким уровнем болезней органов кровообращения (в городах – Дальнереченск, Лесозаводск, Владивосток, Партизанск, Арсеньев и районах – Ханкайском, Октябрьском, Михайловском, Анучинском) вошли следующие поведенческие и биологические факторы: курение, нездоровое питание, низкая физическая активность, избыточное потребление алкоголя, хроническое психоэмоциональное напряжение; высокие уровни гипертензии и содержания глюкозы в крови.

Primary prevention of diseases, especially of the circulatory system, is always considered the most effective method of treatment. With timely correction of metabolic disorders, it is possible to reduce morbidity by 30-40%, disability by up to 50%, and mortality by up to 70%. In Primorsky Krai, diseases of the circulatory system over the past 5 years (2016-2020) are the leading cause of total mortality (about 50% of cases). There was an active increase in indicators of this pathology among the population of cities such as Arsenyev, Dalnerechensk, Lesozavodsk and the formation of new foci in the cities: Dalnegorsk, Ussuriysk, Spassk-Dalny. The analysis of preventable risks affecting the development of diseases of the circulatory system of the population in various districts of Primorsky Krai is carried out. The group of preventable factors noted in the population in areas with a high level of circulatory diseases (in the cities of Dalnerechensk, Lesozavodsk, Vladivostok, Partizansk, Arsenyev and the districts of Khankai, Oktyabrsky, Mikhailovsky, Anuchinsky) included the following behavioral and biological factors: smoking, unhealthy diet, low physical activity, excessive alcohol consumption, chronic psychoemotional stress; high levels of hypertension and blood glucose.
Entre discours de haine en ligne et cyberharcèlement chez un public belge de 15 à 25 ans
Authors: Gangi Océane , Brassine Nadège , Mathys Cécile
Published: February 2023

À l’aune du Web 3.0, la zone d’ombre autour des définitions qualifiant les violences en ligne constitue un obstacle à leur bonne compréhension : haine en ligne, discours de haine et cyberharcèlement sont des termes qui peuvent autant se distinguer que se confondre. Ce constat nous a conduites à rencontrer, par le biais d’entretiens semi-directifs et selon un échantillon de cas multiples, quatorze Belges francophones âgés entre 15 et 25 ans (les digital natives) ayant été victimes, auteurs et/ou témoins de discours de haine en ligne, et présentant une diversité au niveau de l’origine ethnique, du genre, et de l’orientation sexuelle. L’objectif poursuivi est de connaître leurs expériences subjectives liées au discours de haine en ligne. Les résultats qualitatifs seront discutés selon le profil autorapporté par notre échantillon et mis au regard de la conduite de cyberharcèlement, mais également de l’usage de violences verbales, qui ressortent des entretiens menés. L’article se clôturera par une réflexion sur la multitude de formes de discours de haine en ligne exprimées par un échantillon de digital native et la nécessité de s’interroger sur les aspects définitoires de ces comportements, notamment afin de développer des politiques de prévention ciblées du discours de haine en ligne.
Directed Evolution and Predictive Modelling of Galactose Oxidase towards Bulky Benzylic and Unactivated Secondary Alcohols
Authors: Yeo Wan Lin , Tay Dillon W. P. , Miyajima Jhoann M.T. , Supekar Shreyas , Teh Tong Mei , Xu Jin , Tan Yee Ling , See Jie Yang , Fan Hao , Maurer-Stroh Sebastian , Lim Yee Hwee , Ang Ee Lui
Published: February 2023

The growth of industrial biocatalysis for sustainable chemical manufacturing has been limited by the narrow range of chemistries associated with natural enzymes and experiment-intensive regimes of enzyme engineering. Consequently, there has been deep interest to expand enzyme substrate scopes for broader synthetic utility, and to streamline the enzyme engineering process. In the field of alcohol oxidation, galactose oxidase (GOase) is one of the most established enzymes capable of this important chemical transformation under benign conditions. However, the applicability of GOase towards more complex molecules such as those frequently found in the pharmaceutical, or agrochemical industries remains restricted. Here, by employing a combined approach of directed evolution and predictive modelling, we have identified new GOases with significantly expanded substrate specificity toward both bulky benzylic and unactivated secondary alcohols, showing activity enhancements of up to 2,400-fold compared to the reported benchmark M3-5 mutant. Beneficial mutations conveying relaxed substrate enantioselectivity biases (R/S ratios down to 1.05) and higher thermostabilities (up to 20-fold versus benchmark) have also been identified. We have developed predictive models based on computational tools YASARA, FoldX, SCWRL and Glide that are well correlated with features related to enzyme structure, selectivity, protein stability and catalytic activity. The generated enzyme activity models based on Glide-MM/GBSA (r = -0.85) and YASARA (r = -0.89) have successfully predicted the activity trend of a family of related substrates based on the 1-phenyl-1-alkyl alcohol scaffold with varying alkyl chain lengths. It is envisioned that these in silico models can serve as valuable tools to explore desirable enzyme characteristics, establish enzyme substrate scopes, and accelerate biocatalyst development, thus promoting it as a competitive and competent solution for sustainable chemical manufacturing.
Probing the Mechanism of Hydrolytic Degradation of Nerve Agent Simulant with Zirconium-based Metal-Organic Frameworks
Authors: Liao Yijun , Sheridan Thomas , Liu Jian , Lu Zhiyong , Ma KaiKai , Farha Omar , Hupp Joseph
Published: February 2023

Metal-organic frameworks (MOFs) have been reported to effectively detoxify chemical warfare agents (CWAs) and their simulants. Early studies of Zr-MOF-catalyzed hydrolytic degradation of an organophospho-ester type CWA, Sarin, and its simulant, dimethyl-4-nitrophenylphosphate (DMNP), suggested that the activity originates from ZrIV-OH-ZrIV moieties that resemble the structure of the active-site phosphotriesterase enzyme. Measurements of pKa values for hexa-zirconium-node-sited bridging hydroxo, terminal hydroxo, and aqua ligands reveal essentially complete conversion of mu-hydroxo ligands to substitution-inert mu-oxo ligands at alkaline pHs, ruling out a primary role for ZrIV-OH-ZrIV moieties, despite the resemblance to the phosphotriesterase enzyme active-site. The measurements also rule out a secondary role as a hydrogen bond donor/stabilizer of bound DMNP. Additionally, the measurements show that reactant-displaceable node-aqua ligands become increasingly scarce in increasingly alkaline environments. Here, rates of catalyzed hydrolysis reaction were examined experimentally to ascertain reaction orders and, in turn, interrogate the mechanism. In striking contrast to the ubiquitous Zr-MOF, UiO-66, for which simulant displacement of water as a node ligand is rate-determining, and the rate of catalysis (in alkaline environments) increases with decreasing pH, catalysis by NU-1000 is rate-limited by solution hydroxide attack of the nitrophenoxide-phosphorous bond of the MOF-activated simulant, with the overall hy-drolysis rate being remarkably insensitive to pH (or pOH). Underlying the unusually weak sensitivity of rates of hydroly-sis to pH is almost exact counter-balancing of the prevalence of catalyst active-sites (Zr-OH2 sites) with activity of the re-action nucleophile, free hydroxide ion, as a function of pH. We ascribe the residual pH dependence of the overall rate to a charge-based modulation of the equilibrium constant for simulant binding to the node. In contrast to overall hydrolysis rates, the catalyst turnover frequencies per Zr-OH2 active-site are strongly pH dependent, exceeding 30,000 s-1 at pH 10.5.
BRG1 HSA domain interactions with BCL7 proteins are critical for remodeling and gene expression
Authors: Dietrich Nicholas , Trotter Kevin , Ward James M , Archer Trevor K
Published: February 2023

The SWI/SNF complex remodels chromatin in an ATP-dependent manner through the subunits BRG1 and BRM. Chromatin remodeling alters nucleosome structure to change gene expression; however, aberrant remodeling can result in cancer. We identified BCL7 proteins as critical SWI/SNF members that drive BRG1-dependent gene expression changes. BCL7s have been implicated in B-cell lymphoma, but characterization of their functional role within the SWI/SNF complex has been limited. This study implicates their function alongside BRG1 to drive large-scale changes in gene expression. Mechanistically, the BCL7 proteins bind to the HSA domain of BRG1 and require this domain for binding to chromatin. BRG1 proteins without the HSA domain fail to interact with the BCL7 proteins and have severely reduced chromatin remodeling activity. These results link the HSA domain and the formation of a functional SWI/SNF remodeling complex through the interaction with BCL7 proteins. These data highlight the importance of correct formation of the SWI/SNF complex to drive critical biological functions, as losses of individual accessory members or protein domains can cause loss of complex function.
Use of stents with medication coating for the treatment of occlusive-stenotic lesions of the superficial femoral artery
Authors: Nikishyn O.L. , Altman I.V. , Al-Qashgish I.I. , Gavretskiy A.I. , Savoluk S.I. , Muz M.I.
Published: February 2023

Objective ‒ to analyze the results of endovascular revascularization of the femoropopliteal segment with drug-eluting stents. Materials and methods. Endovascular intervention was performed in 23 patients with stenotic lesions of the superficial femoral artery (SFA). Paclitaxel-eluting stents were used. There were 10 men (43.5 %), 13 women (56.5 %). The mean age of the patients was (66.0 ± 3.5) years. There were 16 (69.6 %) patients with diabetes mellitus type 2 and diabetic angiopathy, and 7 (23.4 %) patients had obliterating atherosclerosis of the arteries of the lower limbs. Critical ischemia of the lower extremities was diagnosed in 18 (56.5 %) cases, intermittent claudication ‒ in 5 (21.7 %). Isolated lesions of the femoral-popliteal segment were noted in 3 (13.4 %) patients, lesions of the iliac and femoral-popliteal segments ‒ in 4 (17.4 %), lesions of the femoral-popliteal and ankle segments ‒ in 16 (69.6 %). Results. Twenty (86.6 %) scheduled procedures for stenting of the SFA were technically successful. Among postoperative complications, 3 (13.04 %) patients had puncture site hematomas that did not require surgical evacuation. In 6 (26.1 %) patients, signs of reperfusion syndrome were observed, which were treated with conservative treatment. During follow-up period (3 months), there were no cases of reocclusion or clinically significant restenosis at the stented level. In 1 (5.0 %) case, a hemodynamically significant stenosis of the SFA was observed outside the implanted stent. The patient successfully underwent angioplasty of SFA stenosis. There were no «major» amputations during follow-up period. «Small» ankle amputations were performed in 7 (35.0 %) patients with diabetic gangrene, where endovascular revascularization of the femoro-popliteal and ankle segments was the stage of surgical treatment. Conclusions. Implantation of drug-eluting stents is an effective method of endovascular revascularization in patients with SFA lesions. To compare the results of implantation of drug-eluting stents with other methods of revascularization of the lesions of the femoro-popliteal segment, it is necessary to accumulate more data and increase the duration of the follow-up period.
Multifunctional Intelligent Security Integrated System of Highway Level Crossing
Authors: Dai Min , Wu Chenxiao , Ao Xingwang , Sun Boyu , Yu Hongbo
Published: February 2023

In consideration of the safety of drivers, we designed a multifunctional intelligent seecurity guarantee integrated system for highway level crossing. Different from the existing intersection signs on the market, intelligent highway-level intersection indicators are based on the use of deep learning and computer vision technology to build a convolutional neural network model that can accurately recognize traffic accident images and traffic jams in a short period of time as well as obtain real-time road and highway meteorological environment information.
Avaliação do conhecimento objetivo e percebido do médico da atenção básica quanto à prescrição de contraceptivos hormonais para mulheres com doenças crônicas
Authors: Santos de Carvalho Matheus , Duarte de Araújo Caroliny Carla , Damásio Lia Cruz Vaz da Costa
Published: February 2023

INTRODUÇÃO: O planejamento familiar é direito de todo cidadão, estruturando-se em ações preventivas e educativas para regulação da fecundidade. O médico da atenção básica tem papel primordial nessa assistência, devendo seguir recomendações baseadas em evidências para garantir uma prescrição de contraceptivos adequada e segura. OBJETIVO: Avaliar o conhecimento objetivo e percebido de médicos da atenção básica sobre contraceptivos hormonais em situações especiais. METODOLOGIA: Trata-se de delineamento transversal analítico, desenvolvido no município de Teresina (PI), de junho a agosto de 2019. A população do estudo foi constituída por médicos que atuavam em unidades básicas de saúde da Estratégia Saúde da Família. A amostra do estudo foi de 147 participantes. Além de variáveis sociodemográficas e educacionais, avaliou-se, através de questionário, o conhecimento sobre prescrição de métodos hormonais para mulheres com doenças crônicas, como diabetes com vasculopatia e Hipertensão arterial sistêmica. RESULTADOS: As médias dos escores totais dos médicos que atuam na atenção básica para o conhecimento objetivo e percebido corresponderam a 66,7% e 61,7%, respectivamente, do escore máximo que poderia ser obtido para as situações abordadas.  CONCLUSÃO: Os níveis de conhecimento objetivo e percebido dos médicos foram insatisfatórios, demonstrando a necessidade de investimento em estratégias de capacitação de profissionais da atenção básica quanto à prescrição de métodos hormonais, a fim de oferecer à população acesso a métodos contraceptivos de forma segura e eficaz e, assim, possibilitar oferta de planejamento familiar de qualidade.
Effectiveness of bivalent mRNA booster vaccination against SARS-CoV-2 Omicron infection, the Netherlands, September to December 2022
Authors: Huiberts Anne J , de Gier Brechje , Hoeve Christina E , de Melker Hester E , Hahné Susan JM , den Hartog Gerco , van de Wijgert Janneke HHM , van den Hof Susan , Knol Mirjam J
Published: February 2023

We used data of 32,542 prospective cohort study participants who previously received primary and one or two monovalent booster COVID-19 vaccinations. Between 26 September and 19 December 2022, relative effectiveness of bivalent original/Omicron BA.1 vaccination against self-reported Omicron SARS-CoV-2 infection was 31% in 18–59-year-olds and 14% in 60–85-year-olds. Protection of Omicron infection was higher than of bivalent vaccination without prior infection. Although bivalent booster vaccination increases protection against COVID-19 hospitalisations, we found limited added benefit in preventing SARS-CoV-2 infection.
Análisis Comparativo del Ciclo de Vida - Huella de Carbono de una Edificación de Hormigón Armado Frente a una Edificación de Estructura Metálica
Authors: Erazo Hernández Ramiro Humberto , Pardo Villa Vicente Rafael
Published: February 2023

El proyecto de investigación está orientado a realizar un análisis comparativo de la huella de carbono generada en una edificación de hormigón armado frente a la huella de carbono de una edificación de acero estructural, aplicado a una edificación de 4 pisos de altura la que está conformada por elementos estructurales aporticados. Para lo cual, se aplicó la metodología de análisis del ciclo vida (ACV), metodología que describe de forma sistemática el proceso para la cuantificación de la huella de carbono, mediante la valoración del aporte de las emisiones de gases de efecto invernadero (GEI) en términos de toneladas dióxido de carbono equivalente (t CO2 eq) para cada etapa del ciclo de vida de las edificaciones sujetas de estudio y un periodo de vida útil de 50 años. El análisis del ciclo de vida aplicado empleó un enfoque de producto con un alcance de estudio de la cuna a la cuna, logrando como resultado una huella de carbono para el sistema estructural de hormigón armado de 724,71 (t CO2 eq) y para el sistema estructural de acero 440,93 (t CO2 eq), denotando que las emisiones de gases de efecto invernadero (GEI) para la estructura de hormigón armado es 64,36% mayor a la de acero estructural.

Adicionalmente, como dato complementario a la investigación se determinó el costo ambiental calculado en función de la huella de carbono obtenida para cada sistema estructural, mediante la aplicación del costo al que se cotiza en el mercado las emisiones de (CO2) a la fecha actual, siendo esta de 65,22 €/t CO2 y teniendo en conocimiento que este valor podría aumentar en el transcurso del tiempo debido a las altas emisiones de CO2 que generan los países desarrollados.
BREAST IMPLANT-ASSOCIATED ANAPLASTIC LARGE CELL LYMPHOMA: A LITERATURE REVIEW
Authors: Pompermaier Carolina , Pin Willian Ely , Schenato Mateus Xavier , Franzini Tales Antunes , Cardoso Guilherme Roloff
Published: February 2023

Objective: This review aims to bring updates about the relationship between the silicone implant and the breast implantassociated anaplastic large cell lymphoma (BIA-LCL), in order to have a better knowledge about this disease. Despite the low risk of its development, a better understanding of BIA-ALCL is of interest to women, oncologists, breast specialists, plastic surgeons, regulatory agencies, and the general public, as the number of women with breast implants is increasing worldwide. Methods: This article is based on a review of publications on the topic. A search for articles was carried out through the SciELO databases, at the interface of the U.S. National Library of Medicine and National Center for Biotechnology Information (PubMed) and Latin American and Caribbean Literature on Health Sciences (LILACS). Results: BIA-ALCL is a very rare disease (1 case per 1–3 million women with implants), accounting for 2–3% of these lymphomas in adults and 0.5% of breast cancers and occurs between 8 and 10 years after breast cancer and implantation of a breast prosthesis. Textured implants are the most associated because they have a greater contact surface, so more biofilm is formed, causing bacterial adhesion. Most patients have peri-implant effusion and less often have a mass. Other described symptoms included breast enlargement, skin rash, capsular contracture, and lymphadenopathy. Lymphoma may be located in the seroma cavity or may involve pericapsular fibrous tissue. To make the diagnosis, imaging tests and cytological analysis must be performed. The fluid must be aspirated and is usually cloudy and thick, with large pleomorphic epithelioid lymphocytes, abundant cytoplasm, eccentric reniform nucleus and prominent nucleolus, and anaplastic lymphoma (ALK). Morphological and immunophenotypic features are indistinguishable from those of ALK-negative ALCL. Conclusion: The treatment of BIA-LCL includes implant removal, complete capsulectomy, excision of suspected adenopathy, and excision of lymphoma margins. Surgeons may consider removal of the contralateral implant as approximately 4.6% of cases have demonstrated incidental lymphoma in the contralateral breast. There are no data to recommend a mastectomy, sentinel lymph node biopsy, axillary lymphadenectomy, or breast reconstruction. The best prognosis is with complete capsule elimination surgery. Follow-up is done every 3–6 months for 2 years, in addition to imaging tests and the segment will depend on the patient’s clinical manifestations.
Design of reactor for the production of zinc oxide nanoparticles
Authors: Noorlela Anisa , Nandiyanto Asep Bayu Dani , Ragadhita Risti , Kurniawan Teguh
Published: February 2023

This study aims to design a continuous stirred tank reactor (CSTR) type reactor to produce zinc oxide (ZnO) nanoparticles. Mass balance calculations were carried out in this study as a benchmark to determine whether the reactor was working properly by knowing the flow of incoming raw materials and the products produced by the reactor. Furthermore, the reactor's design and the stirrer used in the reactor are calculated manually using Microsoft Excel. Based on the calculation results of the reactor design, the reactor volume is 8224.359 liters, with a vessel diameter of 73.298 in, a cylinder height of 166.090 in, and a cylinder thickness of 73.444 in. The top cover of the reactor measures 12.387 inches with a thickness of 0.072 inches, while the bottom cover measures 21.185 inches with a thickness of 0.083 inches, so the overall height of the reactor is 37.552 in. The reactor is equipped with one stirrer with an impeller diameter of 36.722 in, impeller height from the bottom of the tank is 24.433 in, impeller width is 7.344 in, and impeller length is 9.180 in. Turbulent stirring flow conditions with a standard motor power for the stirrer is 6.849 HP. This design will be a reference for building more economical, efficient, and highly demanding reactors.
PENDAMPINGAN ANGGOTA KOPERASI KARTINI JAYA DESA SOKO BANDUNG TULUNGAGUNG DENGAN TEMA STRATEGI MEMPERTAHANKAN UMKM DI ERA PANDEMI COVID-19
Authors: Lutfiana Anggraini Fatik
Published: February 2023

Pengabdian ini bertujuan untuk  meminimalisir dampak pandemi terhadap perekonomian masyarakat.  Lokasi pengabdian di  Desa Soko, Bandung, Tulungagung. Metode pada kegiatan ini ialah metode ceramah presentasi, metode ini dipilih untuk menyampaikan konsep-konsep yang penting untuk dimengerti dan dikuasai oleh peserta pelatihan. Penggunaan metode ini dengan pertimbangan bahwa metode ceramah yang dikombinasikan dengan gambar-gambar, animasi dan display dapat memberikan materi yang relatif banyak secara padat, cepat dan mudah. Lokasi pengabdian di  Desa Soko, Bandung, Tulungagung.  Sasaran kegiatan ini adalah anggota Koperasi Kartini Jaya Desa Soko Kecamatan Bandung Kabupaten Tulungagung yang berjumlah 26 orang. Hasil pengabdian menunjukkan bahwa kegiatan tersebut sangat memberikan peluang bagi anggota koperasi yang memiliki UMKM.  Selain itu, terjadi peningkatan dalam mempertahankan usaha yang terjadi di koperasi Kartini Jaya ditunjukkan dengan adanya perubahan-perubahan yang mengarah pada peningkatan daya saing usaha diantaranya, meningkatan kepuasan kerja, munculnya usaha-usaha baru dari anggota, kreatifitas anggota dalam berdagang, memiliki tekat yang kuat dalam bekerja untuk lebih mandiri dan, mengurangi ketakutan menghadapi pandemi.
School and Student Factors and Their Influence on Affective Mathematics Engagement
Authors: Lee Yujin , Capraro Robert M. , Capraro Mary M. , Bicer Ali
Published: February 2023

This study examined the student-level (i.e., gender, home language, and immigration status) and school-level (i.e., school economic disadvantage status) variability of the students’ affective mathematics engagement. It was hypothesized that there is a school effect that contributes toward explaining differences in affective mathematics engagement besides the student-level differences. For the sake of the nested structure of the data in Trends in International Mathematics and Science Study (TIMSS), we used the Hierarchical Linear Modeling (HLM) methodology. There were 10,221 students from 246 schools in the study. The results of this study explained 5.3% of variance in students’ affective mathematics engagement by school-mean economic disadvantage status, where students’ demographic factors explained 1.2%. The present study contributed to a better understanding of the opportunity to learn variables at the student- and school-level in students’ affective mathematics engagement.
The use of characteristics and indicators of body construction as predictors in the identification of the angle values of the physiological curves of the spine in sequential objective testing - mathematical models
Authors: Tuz Jacek , Maszczyk Adam , Zwierzchowska Anna
Published: February 2023

Introduction: The physiological curvatures of the spine in the sagittal plane are constantly evolving along with changes in the structure and proportions of the body and physical activity. The aim of this study is to identify and assess the strength of the influence of body features and indices on the values of lumbar lordosis and thoracic kyphosis angles with the use of a mathematical model. In the years 2006–2016, 1,314 female students aged ( ± SD 19.7 ± 0.4) (min.–max. 18.1–22.5) were examined. Materials and Methods. The following measurements were made: body mass (BM), body height (BH), waist circumference (WC), hips circumference (HC), body fat (%Fat), total body water (%TBW), the value of thoracic kyphosis angles (THKA) and lumbar lordosis angles (LLA). The body mass index (BMI), the body adiposity index (BAI), the waist–hip ratio (WHR) and the waist circumference (WC) were analyzed. Results: WC is the predictor for changes in the value of the angle of thoracic kyphosis, and the BAI is a predictor for changes in the value of angle of lumbar lordosis. Conclusion: The presented mathematical models are a method of non-invasive control of the values of the angles of thoracic kyphosis and lumbar lordosis and support the monitoring of the process of compensation, correction and therapy.
A comprehensive analysis on the grid-tied solar photovoltaics for clean energy mix and supply in Nigeria’s on-grid power
Authors: DİYOKE Chidiebere , NGWAKA Ugochukwu , UGWU Kenneth
Published: February 2023

Nigeria’s power infrastructure is dominated by polluting grid-connected fossil-based power systems. The Nation currently suffers from an acute electricity shortage, making nearly 40% of on-grid customers receive unreliable and inconsistent power below their demand. Solar resources are widespread in the country at considerably good potential than in many European nations. Nevertheless, Nigeria's solar photovoltaic (PV) installation capacity could be better. This paper presents the techno-economic, environmental and risk analysis of a grid-connected 10 kW, 100 kW, and 1 MW PV system for three customer segments in Abuja, Nigeria. It is found that a 1 MW grid-tied PV system is very viable at an electricity export rate not below 0.01 USD/kWh and a total initial cost (TIC) of not more than 2000 $/kW for fixed axis system and 2600 USD/kWh or lower for the two-axis system. The 10 kW and 100 kW PV systems are only financially viable with fiscal incentives. However, they become profitable with a minimum feed-in tariff of about 0.294, 0.297, 0.223 and 0.214 USD/kWh for the fixed 10 kW, 2-axis 10 kW, fixed 100 kW and two-axis 100 kW systems, respectively.
Analysis of Student Constraints in Entrepreneurship through the Analytical Hierarchy Process (AHP) Approach
Authors: Sutarmin Sutarmin
Published: February 2023

To increase the number of entrepreneurs in Indonesia, Peradaban University began to change the patterns of education, so the students not only have high scores in academics but they also have entrepreneurial skills. Despite this subject, entry of students into the field of entrepreneurship has always been faced with many barriers and most of them have not been able to analyze the barriers. This study uses a mixed method of quantitative and qualitative methods. Analytical Hierarchy Process (AHP) was used to analyze the dominant factors of the barriers. While the interview method was used as a qualitative method to find out the solution to the barriers. Respondents in this study were students at Peradaban University that have been entrepreneurs for at least one month. Data were obtained by spreading questionnaires to 32 students and interviewing four students. The result of the analysis shows that the dominant factors are environment of campus barriers (25.79%) followed by financial barriers (24.84%), character barriers (18.48%), educational barriers (17.03%) and family barriers (13.85%). And some solutions provided are learning time management, making the priority scale, approaching the lecturer, looking for investors, and inviting other friends to run the business together.
Dampak Gender pada Pembelian Produk Perawatan Wajah di Negara Beriklim Tropis
Authors: Chairina Raden Roro Lia , Afandi Mochammad Farid , Adove Diddo Adding , Sularso Raden Andi
Published: February 2023

This study aims to investigate the effect of attitudes, subjective norms, and perceived behavioral control on the purchase intention of facial care products based on the theory of planned behavior. The moderating role of gender was also tested on the relationship between purchase intention and factors from the theory of planned behavior. In addition, this research was conducted in a country with a tropical and hot climate which has many cases of facial skin problems. Data collected from 320 respondents were tested against the research model using PLS analysis. The results showed that attitudes, subjective norms, and perceived behavioral control had a significant impact on the purchase intention of facial care products, and it was also found that these factors influenced women more than men on the purchase intention of facial care products. The findings of this study present important theoretical and practical implications for the buying behavior of facial care products.
A SCALE DEVELOPMENT STUDY ON HUBRISTIC LEADERSHIP: A MULTI-FACETED PERSPECTIVE
Authors: ORHAN ŞİMŞEK Nazife , COŞAR Bora
Published: February 2023

It is an undeniable fact that hubristic leaders’ or executives’ over-confidence and over-ambition together with a high level of self-conceit and God-like attitudes over others (i.e., personnel, shareholders, etc.) present a danger for organizations’ ultimate performance and future success since they take systematically strategic decisions and make crucial choices incessantly. By taking all the above into account, the main goals of this study are (1) to contribute to the enhancement of literature regarding the concept of “hubristic leadership” and (2) to develop a multidimensional scale to measure “it, which has been discussed only qualitatively so far but it has not been analyzed quantitatively yet. After having a depth analysis and a closer inspection of the definitions of the construct and the compounds of its items, it is found that the construct is multidimensional comprised of (a) individual, (b) situational, (c) relational.
HEBBEL, PETZOLD VE MEYER’İN ŞİİRLERİNDE ÇEŞME
Authors: YALÇINKAYA AKÇİT Betül , PERK Derya
Published: February 2023

Kaynağı su olan çeşme, insanoğlu için her zaman çok önemli bir olgu olmuştur. Bu sebeple çeşme veya kuyu konu, motif veya sembol olarak edebi eserlerde de karşımıza çıkmaktadır. Batı şiirinde varoluşun kökenini hatırlatması, aynı zamanda yaşam ve ölüm arasındaki dengeli ilişkiye işaret etmesi açısından önemli olan çeşmenin anlamsal boyutundan yararlanmak bu türde oldukça yaygındır. Öyle ki çeşme motifi Novalis, Ludwig Tieck, Eduard Mörike gibi yazarların eserlerinde de yer almıştır. Bu bağlamda bu çalışmada Avusturyalı Alfons Maria Petzold, Alman Friedrich Hebbels ve İsviçreli Conrad Ferdinand Meyer’in konuya ilişkin şiirlerinden örnekler sunulmuştur. Şiirlerinde bulunan çeşmeler verilen açıklamalar kapsamında sembolik anlamlarıyla ve motif olarak incelenmiştir. Sonuçta incelenen şiirlerde Almanca konuşulan ülkelerdeki ortak kültürel bellekte bu olgunun yer aldığı ve kültürü oluşturan etmenlerin açıklanmasında sözlü edebiyat geleneğinden itibaren önemli bir anlatı aracı olduğu ortaya çıkmıştır. Bu noktada çeşme, bahsi geçen çağrışımlarıyla sınırlar ötesi bir işlev üstlenmiştir.
DISCOURSE OF WASIAT WAJIBAH IN REVIEW OF ISTINBATH ISLAMIC LAW
Authors: Marpaung Watni , Adly Muhammad Amar
Published: February 2023

This paper will explain the concept of wasiat wajibah will in review of istinbath Islamic law. The presence of the wasiat wajibah will which is one of the characteristics of Indonesian Islamic law contained in the Compilation of Islamic Law (KHI) is important. Tracing on classical fiqh and Islamic law istinbat methods is a way to legally place a wasiat wajibah will
Decision Support System For The Selection Of The Best Extension Officers Applying The Method Of Additive Ratio Assessment (Case Study: Department Of Agriculture Deli Serdang)
Authors: Hutapea Hotni Rotua Br
Published: February 2023

Agricultural extension workers are agents of change directly related to farmers. The selection of instructors so far that takes place at the Deli Serdang Agriculture Office takes a very long process, based on the problem, a decision support system (SPK) is needed that can facilitate the selection of the best instructors by using existing criteria. One method used is Additive Ratio Assessment (ARAS). The ARAS method is able to solve problems in decision making with alternatives and criteria that have been given weight. Research using ARAS ranks the lowest extension to the highest ranking. The best instructor selection system was built using Microsoft Visual Studio 2008 and MySQL as a database.
Implementation of Weight Sum Model(WSM) in the Selection of Football Athletes
Authors: Sianturi Lince Tomoria
Published: February 2023

Every soccer team has a standard that is used by coaches in determining athletes that fit the criteria owned by athletes. In this study, researchers used a decision support system (SPK) with the Weight Sum Model (WSM) method, which assesses the results of the criteria needed in the selection of soccer athletes. Decisions made in applying the WSM method will produce recommendations according to the standards used by the trainer. The purpose of this research is to apply the WSM method in selecting soccer athletes based on the desired category. The existence of this system is expected to make selection more objective for trainers in making decisions
Data Compression Using Stout Codes
Authors: Nasution Surya Darma
Published: February 2023

The need for data compression is now very important because it is affected by human nature that tends to collect data and also influenced by the need for a process for fast data transfer because the data size becomes smaller. Now many compression algorithms can be used, one of which is the stout codes algorithm. how the stout code algorithm works by encoding characters that often appear with smaller codes than characters with fewer occurrences. The results of data compression in the form of text with the algorithm of the stout code algorithm is the size of the text data becomes smaller with a compression ratio 60% and space saving 40%.
Implementation of Data Mining Using Naïve Bayes Classification Method To Predict Participation of Governor And Vocational Governor Selection In Jemirahan Village, Jabon District
Authors: Fitrani Arif Senja , Fajrillah Fajrillah , Novarika Wirda
Published: February 2023

General Election (ELECTION) is an important political event to determine a leader in a democratic country. The General Election (ELECTION) in East Java which was held on 27 June 2018 yesterday was the election of the Governor and Deputy Governor for the 2019-2024 period. There are two pairs of candidates for Governor and Deputy Governor. Through the General Election (ELECTION) then all parties can be accommodated what they want and aspire to so that a better life can be realized. The community is the determining component of the success or failure of an Election. Therefore, in this study the researcher wanted to examine how the electoral participation in Jemirahan Village, Jabon District by using the classification method, the Naïve Bayes algorithm. To predict the participation of the General Election (PEMILU) in Jemirahan Village, Jabon District, it can be done using the Naïve Bayes Algorithm with 6 predefined variables. The results of the prediction of election participation from the dataset taken were 300 data divided by 2, as many as 65% of 195 training data and 35% of 105 data testing.