bluuebunny/crossref_metadata_2025 huggingface dataset:
Atividade antifúngica de extratos aquosos de plantas medicinais no crescimento micelial de Fusarium graminearum
Authors: Nicolodi Camera Juliane , Koefender Jana , Ferreira Fernandes Ângela Maria , Wagner Soder Elenice Milene
Published: May 2018

O objetivo do trabalho foi avaliar in vitro a atividade antifúngica dos extratos aquosos alho, cebola, cravo-da-índia, carqueja e alecrim sobre o crescimento micelial de Fusarium graminearum Schwabe.  O experimento foi conduzido no Laboratório de Fitopatologia, e o delineamento experimental utilizado foi inteiramente casualizado, com 5 tratamentos e 8 repetições. Utilizaram-se os extratos aquosos filtrados na concentração de 20%,  e a testemunha (somente BDA). Posteriormente os extratos foram incorporados em meio BDA, acondicionados em placas de Petri, onde foram transferidos discos de micélio de F. graminearum medindo 0,2 cm de diâmetro. Após, as placas foram incubadas a 25ºC, com fotoperíodo de 12 horas. Os tratamentos foram analisados em relação ao crescimento micelial da colônia, a percentagem de inibição e a taxa de crescimento de F. graminearum. O extrato aquoso de alho e cravo-da-índia inibiram 100% do crescimento micelial, apresentaram ação antifúngica no crescimento micelial de Fusarium graminearum.
La teoría antropológica de Lo didáctico: Herramientas para Las ciencias de La educación
Authors: Castela Corine
Published: May 2018

El texto propone un primer enfoque sucinto e incompleto de una de las teorías claves de la didáctica de las matemáticas, es decir la teoría antropológica de lo didáctico. Se presentan tres rasgos característicos de la teoría: su focalización en las determinaciones sociales   de   los   fenómenos   indagados,   su   pauta de análisis de las culturas humanas basada en el modelo praxeológico, su enfoque institucional e epistemológico en la enseñanza-aprendizaje.
Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors
Authors: Chiaramonte Niccolò , Romanelli Maria Novella , Teodori Elisabetta , Supuran Claudiu
Published: May 2018

Carbonic Anhydrases (CAs) are a superfamily of metalloenzymes widespread in all life kingdoms, classified into seven genetically different families (α-θ). These enzymes catalyse the reversible hydration of carbonic anhydride (CO2), generating bicarbonate (HCO3-) and protons (H+). Fifteen isoforms of human CA (hCA I-XV) have been isolated, their presence being fundamental for the regulation of many physiological processes. In addition, overexpression of some isoforms has been associated with the outbreak or the progression of several diseases. For this reason, for a long time CA inhibitors (CAIs) are used in the control of glaucoma and as diuretics. Furthermore, the search for new potential CAIs for other pharmacological applications is a very active field. Amino acids constitute the smallest fundamental monomers of protein and, due to their useful bivalent chemical properties, are widely used in organic chemistry. Both proteinogenic and non-proteinogenic amino acids have been extensively used to synthesize CAIs. This article provides an overview of the different strategies that have been used to design new CAIs containing amino acids, and how these bivalent molecules influence the properties of the inhibitors.
Detection of Pathogenic Leptospira in Ornamental Water Fountains from Urban Sites in Cali, Colombia
Authors: Escandón-Vargas Kevin , Bustamante-Rengifo Javier A. , Astudillo-Hernández Miryam
Published: May 2018

Leptospirosis is a disease endemic to both rural and urban areas of tropical countries and resource-poor communities, favored by socioeconomic and climatic determinants. The survival and persistence of pathogenic leptospires in water are key to the epidemiology of the disease. Little information is available on the actual presence of Leptospira spp. in water sources of urban habitats. A study was conducted to detect the presence of pathogenic Leptospira in open-air ornamental water fountains in Cali, Colombia. Twenty-seven water fountains were tested for pathogenic Leptospira using EMJH culture and a multiplex PCR assay targeting the secY and the flaB genes. The presence of pathogenic Leptospira was confirmed in 12 (44%) ornamental water fountains. The isolation frequency of pathogenic Leptospira was highest (67%) for those water fountains located in parks, plazas, building exteriors, and sidewalks. We conclude that ornamental water fountains might be urban reservoirs of pathogenic Leptospira, thereby posing a health hazard to humans. These fountains are frequently outdoors and are exposed to rodents, stray animals, and rainfall. Regular cleaning and disinfection of water in fountains prevent people from exposure, not only to pathogenic Leptospira, but also to other waterborne pathogens.
Medium-frequency Electrical Resistance Sintering of Oxidized c.p. Iron Powder
Authors: Montes Martos Juan Manuel , Gómez Cuevas Francisco , Ternero Fernández Fátima , Astacio López Raquel , Sánchez Caballero Eduardo , Cintas Físico Jesús
Published: May 2018

Commercially pure (c.p.) iron powders with a deliberate high degree of oxidation were consolidated by medium-frequency electrical resistance sintering (MF-ERS). This is a consolidation technique where pressure, and heat coming from a low-voltage and high-intensity electrical current, are simultaneously applied to a powder mass. In this work, the achieved densification rate is interpreted according to a qualitative microscopic model, based on the compacts global porosity and electrical resistance evolution. The effect of current intensity and sintering time on compacts was studied on the basis of micrographs revealing the porosity distribution inside the sintered compact. The microstructural characteristics of compacts consolidated by the traditional cold-press and furnace-sinter powder metallurgy route are compared with results of MF-ERS consolidation. The goodness of MF-ERS versus the problems of conventional sintering when working with oxidized powders is analyzed. The electrical consolidation allows to obtain higher densifications than the traditional route under non-reducing atmospheres.
Hippocampal Volume Changes in Patients with Mood Disorders: A Systematic Review of MRI Studies
Authors: Santos Marcelo Antônio Oliveira , Bezerra Lucas Soares , Brainer-Lima Alessandra Mertens , Carvalho Ana Rita Ribeiro Marinho
Published: May 2018

Background and objectives: due to the neurotoxic effect caused by high levels of cortisol, studies suggest that stress and certain psychiatric disorders, such as mood disorders, have influences under the hippocampus, causing a decrease in volume and consequent memory changes. This study aims to evaluate the relationship between hippocampal volume in patients with mood disorders under therapy. Materials and Methods: the PRISMA protocol for systematic reviews was followed. Pubmed, Cochraine and Scielo databases were searched by terms “Hippocampus”, “Mood Disorders” and “MRI”, and variants in other languages, in human, from January 2011 to September 2016. The individual quality of the articles was analyzed using the Cochraine modified scale for clinical trials and the Agency for Healthcare Research and Quality scale for observational studies. Results: all studies showed reduction of hippocampal volume in depressive patients. Change in hippocampal volume is not related to the use of antidepressant. Particularly the sub-region of the subculum is more reduced, without lateralizations. Significant relationship between stress and right hippocampal reduction. The findings seem to point out: a common pathway of hippocampus reduction, mediated by stress, explaining memory deficits due to depression, where the cortisol pathway seems to act; alteration in the prefrontal cortex; reduction in the subiculum related to inhibition of the hypothalamic-pituitary-adrenal axis, corroborating the hypothesis of cortisol. Conclusions: the papers suggest: association between global hippocampal atrophy with mood disorders; reduction of hippocampal subiculum; refractoriness to clinical treatment among patients with lower hippocampal volume.
Assessment of Hydrocarbon in Place and Recovery Factors in the Eagle Ford Shale Play
Authors: Gherabati S. Amin , Hammes Ursula , Male Frank , Browning John
Published: May 2018

In a low-price environment, experts raise concerns about the economic viability of drilling in many locations across the Eagle Ford Shale play area. Although advances in drilling and completion technologies have helped to reduce the cost of production, reservoir quality still plays the pivotal role in drilling decisions. Eagle Ford reservoir quality is controlled by thermal maturity, which affects fluid composition, initial pressure, and petrophysical properties of the rock. This paper—which estimates original oil in place (OOIP), original gas in place (OGIP), and recovery factors (RFs) driven by reservoir quality—integrates geological and petrophysical analyses, fluid-properties characterization, and decline-curve analysis.

For our petrophysical analysis, we calculated total organic carbon (TOC), lithology, porosity, pay-zone thickness, and water saturation for each square mile of the Eagle Ford play. We divided the play into 12 fluid regions on the basis of reported American Petroleum Institute (API) gravity and gas/oil-ratio (GOR) values and available temperature and pressure maps, developing a representative fluid model for each region to calculate a formation volume factor (FVF). The resulting OOIP and OGIP maps show regions of hydrocarbon accumulation. Our decline-curve forecast uses two-parameter scaling curves that are based on 1D, one-phase flow to predict the estimated ultimate recovery (EUR) of approximately 15,500 existing wells with at least 16 months of oil or gas production. We calculated oil and gas RFs for all the wells, and present a map of their distribution across the Eagle Ford play area.

We generated OOIP and OGIP and RF distribution maps that help to improve the estimation of the amount of recoverable hydrocarbon. The maps reveal the areas with the greatest potential for recovery improvement as well as regions with high-recovery success. RFs calculated on the basis of EUR and well spacing are compared with a material-balance RF that is based on pressure and fluid properties. The Upper Eagle Ford can contribute to production, as indicated through RF plots.
Histiocitose das células de Langerhans no sistema nervoso central: relato de caso incomum
Authors: Menezes Nicássio Silva , Santos Hellen Bandeira de Pontes , Barros Rena Matusa de Oliveira , Lacerda Nereu Alves , Cavalcanti Tânia Regina Ferreira , Cruz Ivana da Silva
Published: May 2018

Introdução: A histiocitose das células de Langerhans é uma doença rara e pouco conhecida, resultante da proliferação clonal das células de Langerhans. Esta doença acomete com maior frequência crianças e suas manifestações clínicas são bem variadas. O envolvimento do Sistema Nervoso Central na histiocitose das células de Langerhans tem sido reconhecido desde os primeiros relatos da doença, porém tem baixa incidência no parênquima cerebral. Objetivo: relatar o caso de um adolescente com diagnóstico de histiocitose das células de langerhans no sistema nervoso central. Relato de caso: O paciente, com quatorze anos de idade, inicialmente, se apresentou com um abscesso de calota craniana. Ao exame de ressonância magnética, evidenciou-se a presença de lesões ósseas líticas na calota craniana e em parênquima cerebral. Os achados encontrados são inespecíficos, porém habitualmente relacionados ao quadro de Histiocitose de células de Langerhans. Foi realizado uma biópsia incisional, com um exame imuno-histoquímico que demonstrou positividade aos anticorpos anti-CD1a, anti-CD68 e anti-S100. Baseado nos achados clínicos, imaginológicos, histopatológicos e imuno-histoquímicos, foi realizado o diagnóstico de histiocitose de células de Langerhans. O tratamento foi feito com a associação de corticoide e quimioterapia. Após um ano de acompanhamento, não se evidencia recorrência da lesão e o paciente apresenta bom estado geral de saúde. Contudo, sendo a histiocitose de células de Langerhans uma doença imprevisível, o paciente deverá ser submetido a reavaliações periódicas.Descritores: Histiocitose; Sistema Nervoso Central; Sinais e Sintomas.
Desordem temporomandibular (DTM): relato de caso de mioespasmo (mialgia de contração tônica)
Authors: Conceicao Helinaldo Corrêa da , Mendonça Dannilo Wiklymber Roldao , Doce Dionísio Leão , Lima Gleicy Gomes de , Araújo Maria de Fátima , Melo Vilma da Silva , Cabral Lioney Nobre , Pinheiro Tiago Novaes
Published: May 2018

O mioespasmo é uma alteração involuntária sustentada por mediação central. É uma alteração em que o músculo permanece contraído por alguns segundos, minutos ou mesmo dias e também é frequentemente observado durante tratamento em que necessitam de sessões prolongadas, como, por exemplo, tratamentos endodônticos de molares.  Depois de determinado tempo, o paciente mostra instabilidade para manter a boca aberta, apresentando episódios de fechamento repentinos. Mioespasmos são facilmente reconhecidos pela disfunção estrutural que produzem. Descrever o diagnóstico de um caso de mioespasmo em paciente com mordida aberta anterior, otalgia e dor na própria ATM. A paciente M.M.S.R, 33 anos, gênero feminino, cor parda, compareceu ao atendimento na Policlínica da UEA para exame estomatológico de rotina. Durante a anamnese a paciente relatou que sentia dores de cabeça, dor de ouvido, apertamento dos dentes durante a noite e possuía o elemento 46 fraturado, relatou também ter ido ao dentista fazer a restauração do elemento dental 46 há aproximadamente um ano e que, passado alguns dias do procedimento começou a ter dores de cabeça frequentemente, porém a paciente relatou ser muito estressada. Por conseguinte, a etiologia dos mioespasmos não tem sido bem documentada. É provável que muitos fatores se combinem para promover o mioespasmo. Condições musculares locais certamente aparecem para criar mioespasmos: as dores de cabeça, de ouvido, dor facial, má oclusão aguda, dentre outros. Compete ao cirurgião-dentista diagnosticar e tratá-las em conjunto com outras especialidades.Descritores: Espasmo; Mialgia; Mordida Aberta; Otite; Transtornos da Articulação Temporomandibular.
Perfuração radicular lateral em um dente com calcificação pulpar: um relato de caso
Authors: Marques Izabela Volpato , Pavan Nair Narumi Orita , Queiroz Alfredo Franco , Morais Carlos Alberto Herrero de , Barbosa Josimeire Alves Pereira , Ishida Aline Lie , Endo Marcos Sergio
Published: May 2018

A calcificação pulpar pode representar um desafio ao tratamento endodôntico principalmente durante a abertura coronária.  A correta avaliação dos aspectos clínicos e radiográficos é indispensável para evitar a perfuração radicular. Este trabalho tem como objetivo mostrar por meio do relato de um caso clínico o selamento de uma perfuração radicular lateral com Agregado Trióxido Mineral (MTA). Paciente, 32 anos, sexo feminino, com queixa de dor leve ao mastigar no dente 25, desde que foi atendida na Unidade Básica de Saúde. Clinicamente, o dente 25 apresentava restauração provisória oclusomesial, não respondeu ao teste de sensibilidade pulpar, e o periodonto estava normal. Radiograficamente, havia sugestão de perda óssea mesial e comunicação com o ligamento periodontal. Na tomografia computadorizada de feixe cônico confirmou-se a presença de perfuração na face mesiopalatina, no terço médio, com perda óssea, comunicação com o ligamento periodontal e calcificação do canal radicular. Devido à presença de tecido de granulação, optou-se pela descontaminação e indução de reparo da área por meio da inserção de medicação a base de hidróxido de cálcio associado ao propilenoglicol.  Após 12 meses de trocas deste curativo, foi realizado selamento com MTA branco em íntimo contato com o periodonto. Realizou-se a blindagem coronária com cimento de ionômero de vidro e resina composta.  Apesar da localização e do tamanho desfavorável para o selamento desta perfuração, após 1 ano verificou-se no controle clínico-radiográfico-tomográfico que diante do tratamento executado o dente mostra-se em função, reparação óssea e assintomático.Descritores: Endodontia; Calcificações da Polpa Dentária; Tomografia Computadorizada de Feixe Cônico.
Simulating surface flow and baseflow in Poko catchment, Kon Tum province, Vietnam
Authors: Tram Vo Ngoc Quynh , Liem Nguyen Duy , Loi Nguyen Kim
Published: May 2018

Estimating the volume of water resources has important significance in assessing water availability in a basin, particularly in mountainous areas. The Poko catchment, a sub-basin of Se San river basin, is located in the Central Highland of Vietnam with an area of about 3,210 km2. This study focused on evaluating the performance of SWAT model and baseflow filtering algorithm in simulating surface flow and baseflow in Poko catchment. The model was calibrated and validated for the period 1996–2004 and 2005–2013, respectively, using the observed water discharge data at Dak Mot stream gauge. Statistical measures including R2 (coefficient of determination), NSI (Nash–Sutcliffe index), and PBIAS (percent bias) indicated good performance of the model in simulating water discharge on monthly time step during the calibration and validation period. Using baseflow filtering algorithm with filter parameter (0.925), surface flow and baseflow were separated from water discharge. The results demonstrated good performance in capturing the patterns of surface flow and baseflow, which confirmed the appropriateness of the model for future scenario simulation. These findings provide useful information for water resources planning in Poko catchment, in particular, and other basins, which have a hydro-meteorological response similar to this catchment, in general.
Impact of coastal environmental factors on quinolone distribution in intertidal surface sediments of the Bohai Sea and Yellow Sea, China
Authors: Lang Hang , Chen Liang , Hou Guohua , Wang Wenjuan , Zou Shengzhang , Luo Ximing
Published: May 2018

Freshwater contaminants tend to precipitate into intertidal surface sediments, particularly in the estuary and intertidal zones during freshwater–seawater mixing. Quinolone-type antibiotics are such contaminants, and their concentrations in the intertidal sediments are important indicators for the whole spectrum of antibiotics used in the estuary and adjacent areas. The impacts of sediment types and environmental factors on the distribution of 16 quinolones were probed based on nine Bohai and 42 Yellow Sea intertidal sediment samples. The samples were collected from locations along the coastal areas in China. Quinolones were detected in all samples, while moxifloxacin, ciprofloxacin, and ofloxacin were detected at a frequency >50%. Sediment types, pH, organic carbon content, K, Na and Fe concentrations had little correlation with quinolone distributions in intertidal sediments. However, combined concentrations of Ca + Mg (46.7 g/kg in Bohai and 13.7 g/kg in Yellow Sea samples) appeared to correlate with oxolinic acid detecting frequencies (88.9% and 4.8%, respectively) and concentrations (2.0–10.1 μg/g and up to 3.09 μg/g, respectively). Different detection frequencies of the quinolones could be attributed to the formation of cation bridges between oxolinic acid and Ca + Mg, which results in dominant sorption of oxolinic acid at different locations and sediment matrices.
Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD)
Authors: Russo Patrizia , Prinzi Giulia , Lamonaca Palma , Cardaci Vittorio , Fini Massimo
Published: May 2018

Background:

Chronic Obstructive Pulmonary Disease (COPD) and Cardiovascular
Diseases (CV) Often Coexist. COPD and CVD are complex diseases characterized by a strict
interaction between environment and genetic. The mechanisms linking these two diseases are
complex, multifactorial and not entirely understood, influencing the therapeutic approach.
COPD is characterized by several comorbidities, it hypothesized the treatment of cardiovascular
co-morbidities that may reduce morbidity and mortality. Flavonoids are an important class
of plant low molecular weight Secondary Metabolites (SMs). Convincing data from laboratory,
epidemiological, and human clinical studies point the important effects on CVD risk
prevention.

Objective:

This review aims to provide up-to-date information on the ability of Flavonoids to
reduce the CVD risk.

Conclusion:

Current studies support the potential of Flavonoids to prevent the risk of CVD.
Well-designed clinical studies are suggested to evaluate advantages and limits of Flavonoids
for managing CVD comorbidity in COPD.
Chronic Low Back Pain: Current Pharmacotherapeutic Therapies and a New Biological Approach
Authors: Pavelka K. , Jarosova H. , Sleglova O. , Svobodova R. , Votavova M. , Milani L. , Prochazka Z. , Kotlarova L. , Kostiuk P. , Sliva J. , Meroni A.M.
Published: May 2018

Chronic low back pain (CLBP) syndrome represents one of the leading causes of long-term disability worldwide. The prevalence of CLBP has been rising significantly in relation to increasing average life expectancy. CLBP results from chronification of acute low back pain. There are many factors contributing to the CLBP crisis; common etiopathogenetic factors include e.g., functional blockage of intervertebral joints. The treatment of CLBP is complex. An important part of treatment consists of pain pharmacotherapy, for which several groups of drugs are used. The problem lies in the side effects of many of these traditionally used medications. Therefore, new and safer treatment methods are being sought. Innovative options for CLBP pharmacology include injections containing collagen, which can be combined with other traditionally used drugs, which helps reduce dosages and increase the overall safety of CLBP therapy.
Using Augmented Reality to Motivate Oral Hygiene Practice in Children: Protocol for the Development of a Serious Game (Preprint)
Authors: Amantini Susy Nazaré Silva Ribeiro , Montilha Alexandre Alberto Pascotto , Antonelli Bianca Caseiro , Leite Kim Tanabe Moura , Rios Daniela , Cruvinel Thiago , Lourenço Neto Natalino , Oliveira Thais Marchini , Machado Maria Aparecida Andrade Moreira
Published: May 2018

BACKGROUND

New technologies create possible new ways of action, interaction, and learning which is extremely relevant in the field of oral health education. There is a lack of protocol in using an immersive interactive ludic-educational interface to motivate oral hygiene practice in children by means of augmented reality.

OBJECTIVE

This study aims to present a protocol on the development of a serious game to motivate oral hygiene practice in children.

METHODS

A serious game will be designed by augmented reality techniques to improve toothbrushing effectiveness of children aged 6 to 10 years. The functional structure of this interface is activated by means of movements recognized by Kinect (Microsoft Corp). The toothbrushing technique will be available in the game, enabling the children to execute the movement in the virtual environment. By identifying errors, this game will be tailored to improve the oral health of children by correcting the technique and teaching the user the adequate toothbrushing method. A template analysis will be performed to identify barriers and facilitators in each scenario.

RESULTS

After the implementation of the virtual interactive and immersive panels, enrollment will begin and evaluations will be made by means of questionnaires distributed to participants who interact with the game. Thus, an analysis of the product efficacy will be conducted. The expected outcome will be to obtain a digital instrument to motivate oral hygiene practice and enhance health awareness in children.

CONCLUSIONS

The serious game will support the prevention of oral diseases by sharing scientific research in the school environment and community.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/10987
Detecting Potential Adverse Drug Reactions Using a Deep Neural Network Model (Preprint)
Authors: Wang Chi-Shiang , Lin Pei-Ju , Cheng Ching-Lan , Tai Shu-Hua , Kao Yang Yea-Huei , Chiang Jung-Hsien
Published: May 2018

BACKGROUND

Adverse drug reactions (ADRs) are common and are the underlying cause of over a million serious injuries and deaths each year. The most familiar method to detect ADRs is relying on spontaneous reports. Unfortunately, the low reporting rate of spontaneous reports is a serious limitation of pharmacovigilance.

OBJECTIVE

The objective of this study was to identify a method to detect potential ADRs of drugs automatically using a deep neural network (DNN).

METHODS

We designed a DNN model that utilizes the chemical, biological, and biomedical information of drugs to detect ADRs. This model aimed to fulfill two main purposes: identifying the potential ADRs of drugs and predicting the possible ADRs of a new drug. For improving the detection performance, we distributed representations of the target drugs in a vector space to capture the drug relationships using the word-embedding approach to process substantial biomedical literature. Moreover, we built a mapping function to address new drugs that do not appear in the dataset.

RESULTS

Using the drug information and the ADRs reported up to 2009, we predicted the ADRs of drugs recorded up to 2012. There were 746 drugs and 232 new drugs, which were only recorded in 2012 with 1325 ADRs. The experimental results showed that the overall performance of our model with mean average precision at top-10 achieved is 0.523 and the rea under the receiver operating characteristic curve (AUC) score achieved is 0.844 for ADR prediction on the dataset.

CONCLUSIONS

Our model is effective in identifying the potential ADRs of a drug and the possible ADRs of a new drug. Most importantly, it can detect potential ADRs irrespective of whether they have been reported in the past.
Access to Resources in the Community Through Navigation: Protocol for a Mixed-Methods Feasibility Study (Preprint)
Authors: Dahrouge Simone , Gauthier Alain , Chiocchio Francois , Presseau Justin , Kendall Claire , Lemonde Manon , Chomienne Marie-Hélène , Perna Andrea , Toal-Sullivan Darene , Devlin Rose A , Timony Patrick , Prud'homme Denis
Published: May 2018

BACKGROUND

Community-based health and social resources can help individuals with complex health and social needs achieve their health goals. However, there is often inadequate access to these resources due to a lack of physician and patient awareness of available resources and the presence of social barriers that limit an individual’s ability to reach these services. Navigation services, where a person is tasked with helping connect patients to community resources, embedded within primary care may facilitate access and strengthen the continuity of care for patients.

OBJECTIVE

This study aims to describe the protocol to assess whether the implementation of the Access to Resources in the Community (ARC) navigation model (an innovative approach to navigation services) is feasible, including its potential to achieve its intended outcomes, and to assess the viability of the evaluation approach.

METHODS

The study consists of a single-arm, prospective, explanatory, mixed-methods, pre-post design feasibility study focusing on primary care practice settings with vulnerable populations. Participants include primary care providers and patients.

RESULTS

Enrollment is closed with 82 patients. Navigation services have ended for 69 patients.

CONCLUSIONS

The study of an innovative complex intervention requires an adequate assessment of the feasibility of the intended approach during which the potential challenges of the planned intervention and need for its adaptation may be uncovered. Undertaking a feasibility study of the ARC navigation model from a conceptually clear and methodologically solid protocol will inform on the practicality and acceptability of the approach, demand for the services, ease of implementation, quality of integration of the new services within primary care, and practicality and potential for efficacy prior to initiating a randomized controlled trial.

CLINICALTRIAL

ClinicalTrials.gov NCT03105635; https://clinicaltrials.gov/ct2/show/NCT03105635 (Archived by WebCite at hhttp://www.webcitation.org/75FrwXORl)

INTERNATIONAL REGISTERED REPOR

RR1-10.2196/11022
Patient-centric portable health record exchange: A feasibility study (Preprint)
Authors: Ozols Audrey , Luskin Eugene , Buehrens Paul
Published: May 2018

BACKGROUND

Patient medical records contain important information for healthcare professionals to make the right decisions that provide efficient care and optimize quality patient outcomes. Electronic health record (EHR) systems are now the standard to document patient health information. However, the exchange of patient protected health information remains a challenge due to the lack of connectivity across hundreds of different EHR systems.

OBJECTIVE

The aim of the study is to describe the implementation of a secure and EHR-agnostic portable patient medical record technology, and to describe initial user experiences.

METHODS

We developed the VYRTY solution, a HIPPA compliant and secure medical record card and reader that allows for user authentication, patient authentication, data capture, data storage, and documentation sharing that works with any EHR system. Storage of all patient medical records is encrypted on the VYRTY card allowing safe patient transportation of medical records. Physician activation was phased in over the first 5 months of the one-year pilot. Patient enrollment was voluntary and was complete within 8 months from start of the pilot. Physicians uploaded medical record documents from their EHR by using the print function. Patients that were referred shared their VYRTY card with the receiving physician for downloading of medical records. The exchange of medical records was recorded by the VYRTY system and personal interviews were conducted and recorded to assess user experience.

RESULTS

One hundred and ninety-four patients participated out of 200 enrolled, while 23 physicians actively participated out of 45 enrolled. Patients utilized their VYRTY cards 49% of the time, and physicians downloaded documents 51% of the time during the 1-year pilot period. Participating physicians found VYRTY easy to use and their patients were very satisfied with the convenient portability of their medical records.

CONCLUSIONS

VYRTY was implemented successfully and found to be easy to use by physicians and patients. Using the VYRTY system gave patients their own medical records to share with other providers, which effectively solved the problem of exchanging health information between different EHR systems.
Using eHealth to Reach Black and Hispanic Men Who Have Sex With Men Regarding Treatment as Prevention and Preexposure Prophylaxis: Protocol for a Small Randomized Controlled Trial (Preprint)
Authors: van den Berg Jacob J , Silverman Taylor , Fernandez M Isabel , Henny Kirk D , Gaul Zaneta J , Sutton Madeline Y , Operario Don
Published: May 2018

BACKGROUND

Black and Hispanic men who have sex with men in the United States continue to be disproportionately affected by HIV and AIDS. Uptake of and knowledge about biobehavioral HIV prevention approaches, such as treatment as prevention and preexposure prophylaxis, are especially low in these populations. eHealth campaigns and social media messaging about treatment as prevention and preexposure prophylaxis may help to fill this gap in knowledge and lead to increased uptake of such strategies; however, no evidence exists of the effects of these targeted forms of communication on treatment as prevention and preexposure prophylaxis uptake in these populations.

OBJECTIVE

We describe the protocol for a 3-part study aiming to develop and evaluate an eHealth intervention with information about treatment as prevention and preexposure prophylaxis for HIV-positive and HIV-negative black and Hispanic men who have sex with men.

METHODS

Phases 1 and 2 will involve focus groups and cognitive interviews with members of the target populations, which we will use to create a culturally tailored, interactive website and applicable social media messaging for these men. Phase 3 will be a small randomized controlled trial of the eHealth intervention, in which participants will receive guided social media messages plus the newly developed website (active arm) or the website alone (control arm), with assessments at baseline and 6 months.

RESULTS

Participant recruitment began in August 2017 and will end in August 2020.

CONCLUSIONS

Public health interventions are greatly needed to increase knowledge about and uptake of biobehavioral HIV prevention strategies such as treatment as prevention and preexposure prophylaxis among black and Hispanic men who have sex with men. eHealth communication campaigns offer a strategy for engaging these populations in health communication about biobehavioral HIV prevention.

CLINICALTRIAL

ClinicalTrials.gov NCT03404531; https://www.clinicaltrials.gov/ct2/show/NCT03404531 (Archived by WebCite at http://www.webcitation.org/70myofp0R).

REGISTERED REPORT IDENTIFIER

RR1-10.2196/11047
Analysis of Layout of Yogyakarta Airport Railway Station and Its Integration with Tugu Railway Station
Authors: Atmakusuma Prabendra A. , Parikesit Danang
Published: May 2018

The government of Indonesia plans to build new airport that is located in Temon Sub-district, Kulon Progo Regency. However, the distance of the airport is quite far from the center of Yogyakarta City, therefore it is necessary to build a railway that functioned as a connector. The operating airport railway would then means an Airport Railway Station that is located in the center of Yogyakarta City, in order to accommodate the fluency of railway operation. This paper is intended to give information on the layout design, and also the location of Airport Railway Station in the center of Yogyakarta City. To generate layout of railway that is integrated with Tugu Railway Station of Yogyakarta, the methods used were: determining the station classification, determining the zone, the circulation and wayfinding, so that the passengers could move fluently. Based on the analysis result, the Airport Railway Station has categorized a large class station, with its location was designed separately from the Tugu Railway Station, but integrated with 52 meters long tunnel in south of the Airport Railway Station. The layout design of the Airport Railway Station was designed to be two levels and with two platforms with land necessity of 9100 m2, and was predicted to serve 515 passengers per rush hour.
Tsunami Disaster Preparedness Simulation on North Buton Regency
Authors: Sanjaya Jajang , Triatmadja Radianta , Triatmodjo Bambang
Published: May 2018

Geographical location of North Buton Regency which directly opposite the Banda Sea and placed in the reverse fault of Makassar Strait, Matano fault, Lawanoppo, and Kolaka, which are tsunami-prone areas due to earthquake and submarine landslide. These then caused the area has high disaster risk, because of the settlement that is located on the seashore. Therefore, a study to understand the preparedness level of community in North Buton Regency in confronting the tsunami disaster is needed; in order to be able to determine the mitigation steps, also the effective evacuation route and location to minimize the casualties caused by tsunami. Kulisusu Sub-district is a territory with a fairly long coastal area, wherein the population density is the highest in North Buton Regency, this then made the area has high disaster risk. This research used questionnaire instrument to discover the preparedness level of the community, and the numerical simulation method with multi-agent system in the tsunami evacuation simulation. The conducted simulation did not specify the evacuation route or path, yet the agents were allowed to move freely to the shelter. The simulation was conducted at day and night time. The result of the research pointed on matter of preparedness level of community, in which factor of preparedness of the community in facing the disaster is very important, by the means of establishing simulation drill, preparing the controller officers, and managing the comfort on the shelter, such as strategic location and good position, also creating a good early warning system so that more residents could be saved.
Migration and Human Development in Kalimantan
Authors: Effendi Tadjuddin Noor , Manning Chris
Published: May 2018

Kajian ini ditujukan untuk mencermati peran migrasi dalam pertumbuhan populasi secara keseluruhan dan bagaimana hal tersebut berkaitan dengan perubahan ekonomi dan sosial, bahkan peningkatan sumberdaya manusia di Kalimantan, baik secara historis maupun dalam perkembangannya saat ini. Hal tersebut memiliki implikasi penting dan bervariasi bagi pembangunan ekonomi dan sosial, serta lingkungan hidup, khususnya sebagai dampak yang memiliki perbedaan di setiap tingkat lokal dan distrik. Selain memfokuskan secara khusus pada satu aspek perubahan wilayah, kajian ini juga menjelaskan konteks atas pembangunan sosial secara keseluruhan di Kalimantan. Kajian ini mengindikasikan bahwa migrasi yang berlangsung di Kalimantan secara signifikan berkontribusi pada perbaikan standar kehidupan dan pengurangan angka kemiskinan, meskipun kompetisi yang ketat dan tingginya angka pertumbuhan populasi di wilayah-wilayah yang dikaji. Analisis ini menunjukkan adanya kebenaran dalam perspektif regional, meskipun masyarakat lokal menanggung ongkos sosial akibat dari aliran migrasi yang cukup besar. Oleh karena itu, analisis mengenai perubahan sosial dan lingkungan hidup juga perlu dikaji secara serius sehingga manfaat yang dikenali bukan hanya dapat dinikmati oleh para migran tetapi juga oleh masyarakat lokal, dan khususnya bagi generasi saat ini dan di masa depan.
Pekerja Migran dan Ekonomi Informal Ilegal (Prostitusi) di Wilayah Pasar Kembang, Yogyakarta
Authors: Artosa Odam Asdi
Published: May 2018

Malioboro merupakan salah satu kawasan aktivitas perekonomian yang relatif besar khususnya yang berkaitan dengan industri pariwisatadi Yogyakarta. Di kawasan tersebut dapat ditemui berbagai macam aktivitas ekonomi informal yang sudah ada sejak zaman kolonial, mulai dari pedagang kaki lima hingga prostitusi.Pasar Kembang adalah salah satu wilayah khusus pariwisata yang berlokasi di utara Malioboro memiliki keragaman praktik ekonomi informal dan diduga juga menjadi lokasi praktik ilegal prostitusi. Berangkat dari konteks itu, kajian ini bertujuan untuk melihat dinamika sektor informal yang bersifat ilegal seperti prostitusi khususnya yang diduga telah berlangsung di wilayah Pasar Kembang. Penelitian ini menggunakan metode pendekatan fenomenologi yang bertujuan untuk menyajikan suatu analisis mengenai aktivitas ekonomi informal yang bersifat ilegal dengan cara memperoleh informasi mendalam atau gambaran penjabarannya mengenai praktik prostitusi dari perspektif para informan yang terlibat dalam kajian ini. Hasil penelitian menunjukkan bahwa pekerja migran yang kesulitan mendapatkan pekerjaan di sektor formal dan juga praktik ekonomi informal yang legal harus menegosiasikan tekanan hidup karena kebutuhan ekonomi dengan memilih jalan pintas dalam praktik prostitusi ilegal.
Innovación docente en la Educación Superior Intercultural notas introductorias al número especial
Authors: Gunther Dietz , Mateos Cortés Laura Selene
Published: May 2018

La innovación educativa en general y la innovación docente en particular, se han convertido en una panacea aclamada por todo tipo de actores educativos, gubernamental y no -gubernamental, público y privado, que interviene en los debates contemporáneos sobre la educación y las reformas educativas. Tanto en la educación escolar básica, como en la educación superior, la innovación se vuelve prácticamente un sinónimo de “modernización” y de “tecnologización” educativa. Frente a este uso reduccionista- y obviamente influido por intereses relacionados con la mercantilización de determinados procesos áulicos-, reivindicamos una comprensión más crítica y holística de la innovación como proceso de cambio educativo, que se inspira en la pedagogía alternativa, comprometida con la transformación integral de las instituciones escolares.
Corporalidad, creación escénica y teatro comunitario en la Universidad Veracruzana Intercultural (UVI)
Authors: Eguiarte Espejo Claudia Patricia
Published: May 2018

Este artículo explicita algunas directrices centrales de un proyecto de investigación, basado en el desarrollo de habilidades comunicativas y creativas en estudiantes universitarios para la creación escénica, la aplicación del teatro en la animación y conducción de acciones de revitalización lingüística de idiomas originarios, además de generar e implementar procesos de gestión para mejorar las condiciones de vida de comunidades, principalmente rurales, del estado de Veracruz. En particular, el proyecto se ha llevado a cabo en las zonas donde están ubicadas las cuatro sedes de la Universidad Veracruzana Intercultural y de manera específica, el artículo se centra en el trabajo realizado en la Sede Regional Grandes Montañas, donde ha sido posible consolidar un grupo de teatro bilingüe comprometido con la práctica de la animación sociocultural, mediante el teatro comunitario.
CARTILHA EDUCATIVA PARA MULHERES SOBRE INCONTINÊNCIA URINÁRIA: CONCEPÇÃO E DESENVOLVIMENTO
Authors: Oliveira Antônio Hérbetty Arcanjo Martins , De Vasconcelos Thiago Brasileiro , Macena Raimunda Hermelinda Maia , Bastos Vasco Pinheiro Diógenes
Published: May 2018

A Incontinência Urinária é um distúrbio frequente entre mulheres que causa incômodo e constrangimento. O desconhecimento sobre a patologia e seu tratamento (clínico ou cirúrgico) tem aparecido como um grave problema de saúde pública. Este estudo teve o objetivo de descrever o processo de concepção e desenvolvimento de um material educativo sob o formato de uma cartilha destinada à promoção da saúde da mulher acometida pela doença. Para tanto, realizou-se uma pesquisa-ação que se utilizou dos pressupostos freireanos de abordagem qualitativa e interpretativa na área do processo de ensino-aprendizagem que foi desenvolvida em quatro etapas (escolha do conteúdo, criação das ilustrações, preparação do layout e validação do material por peritos). Foi elaborada uma cartilha com dimensões de 20 x 14 centímetros de altura e largura, impressa em papel couchê e denominada com o título Incontinência Urinária não é normal em nenhuma fase da vida e tem tratamento. Concluiu-se que o desenvolvimento de material de informação, educação e comunicação firma-se como um ponto promissor do trabalho do fisioterapeuta no tocante às ações de promoção e prevenção na saúde da mulher na atenção básica.

Palavras-chave: Incontinência Urinária. Prevenção de Doenças. Assoalho Pélvico. Educação em Saúde.
USO DE FITOTERÁPICOS E POTENCIAIS RISCOS DE INTERAÇÕES MEDICAMENTOSAS: REFLEXÕES PARA PRÁTICA SEGURA
Authors: Dias Eliana Cristina Moura , Trevisan Danilo Donizetti , Nagai Silvana Cappelleti , Ramos Natália Amorim , Silva Eliete Maria
Published: May 2018

A segurança do paciente tem sido, atualmente, assunto recorrente na pauta de discussões internacionais, em virtude da grande necessidade de as instituições de saúde passarem a realizar processos mais seguros para uma redução significativa de danos evitáveis à saúde. Em relação ao uso de fitoterápicos, em várias partes do mundo, há um aumento significante em seu uso. Porém, a administração concomitante de medicamentos convencionais e fitoterápicos pode alterar os níveis de respostas a determinados receptores, aumentando as chances de Interação Medicamentosa. As Interações Medicamentosas entre medicamentos alopáticos e fitoterápicos podem causar alterações relevantes nas concentrações plasmáticas dos medicamentos e, consequentemente, mudanças em seus perfis de eficácia e/ou segurança. Este artigo apresenta interações medicamentosas potenciais, envolvendo plantas medicinais e fitoterápicos encontradas na literatura, visando a subsidiar a indicação segura dos mesmos pelos profissionais de saúde. Para que haja utilização coerente da fitoterapia como tratamento complementar, a mesma deve ser indicada por um profissional de saúde com especialização em fitoterapia, a fim de proporcionar uma assistência mais segura e com qualidade, visando a um cuidado integral ao paciente.

Palavras-chave: Fitoterapia. Interação de medicamentos. Segurança do paciente.
A study of the effect of magnetic fields on the diffusion layer at the Fe/H2SO4 interface by holographic microphotography
Authors: Wang Chao , Chen Shenhao
Published: May 2018

The effect of externally imposed magnetic fields on the relaxation of the
concentration diffusion layer at the Fe/0.5 mol dm-3 H2SO4 interface after
passivation of the iron electrode during potentiodynamic polarization was
studied by holographic microphotography. The presence of a magnetic field
was found to retard the relaxation process while the microturbulence was
impeded.
Surface roughness minimum: Ag thin layer deposited on a glass
Authors: Petrovic R. , Strbac S. , Bundaleski N. , Rakocevic Z.
Published: May 2018

In this paper the results of an examination of the surface roughness and
morphology dependence of silver thin films up to 100 nm thick deposited on a
microscope glass on the deposition rate and on the deposition time are
presented. It was found that, for a constant deposition rate, the surface
roughness exhibits minimum at a certain layer thickness. This coincides with
the turning point when the influence of the substrate surface on the
deposition process becomes negligible, i.e., to the change in the nature of
the system substrate/deposit from Ag/glass to Ag/Ag. For a constant layer
thickness, sthe surface roughness minimum, achieved at a certain deposition
rate, coincides to the turning point when the average free path for vertical
adatom mobility becomes zero.
The current distribution in an electrochemical cell. Part VI: The quantitative treatment for cells with three plane parallel electrode arrangements
Authors: Popov K.I. , Pesic S.M. , Zivkovic P.M.
Published: May 2018

Amethod for the quantitative determination of the current density distribuion
in cells with a three plane parallel electrode arrangement is proposed. It
is shown that the current density distribution can be determined using the
data obtained by simple polarization measurements. The relation to the
Haring-Blum cell with P = 2 is discussed.
Optimization of cultivation medium composition for production of bioactive compounds effective against Penicillium sp.
Authors: Roncevic Zorana , Pajcin Ivana , Cvetkovic Dragoljub , Dodic Sinisa , Grahovac Jovana , Dodic Jelena
Published: May 2018

Biological control is one of the best alternatives to pesticides as it avoids
their weak points in plant disease control. In this study, the composition
of cultivation medium for production of bioactive compounds by Bacillus
subtilis ATCC 6633 was optimized. The produced bioactive compounds were
tested against a phytopathogenic Penicillium sp. known for infesting
different agricultural products and causing substantial crop losses.
Antimicrobial activity assaying was carried out using the diffusion-disc
method, and inhibition zone diameters were measured as direct indicators of
antifungal activity. The response surface methodology (RSM) was used to
evaluate the effects of different contents of initial nutrients (glycerol,
NaNO2 and K2HPO4) in cultivation medium on inhibition zone diameter.
Optimization was carried out using the desirability function method in order
to maximize bioactive compounds yield and to minimize residual nutrients
contents. The optimized concentrations of the selected nutrients in
cultivation medium for production of bioactive compounds were: glycerol 20
g/l, NaNO2 1 g/l and K2HPO4 15 g/l.