bluuebunny/crossref_metadata_2025 huggingface dataset:
Potato protein isolate‐based biopolymers
Authors: Du Yicheng , Chen Fangping , Zhang Yachuan , Rempel Curtis , Thompson Michael R. , Liu Qiang
Published: July 2015

Thermal processing of two potato protein isolates (PPIs) with glycerol as a plasticizer was explored in this study. The PPIs were pretreated by alkali or alkali under reducing conditions. The PPIs before and after pretreatment were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis, differential scanning calorimetry, and Fourier transform infrared spectroscopy. The effects of plasticizer content and pretreatment on mechanical and thermo‐mechanical properties of the compression‐molded biopolymers were studied. The highest tensile strengths obtained were 20–25 MPa and the biopolymer can be brittle or ductile depending on the plasticizer contents. The molecular weight and protein structure of the PPIs markedly affected the resultant biopolymers’ static and dynamic mechanical properties. The pretreatment of PPIs caused distinctly different changes in the mechanical properties of the two PPIs. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42723.
Fabrication of durable hydrophobic cellulose surface from silane‐functionalized silica hydrosol via electrochemically assisted deposition
Authors: Guo Ning , Chen Yuanhui , Rao Qingqing , Yin Yunjie , Wang Chaoxia
Published: July 2015

Durable excellent hydrophobic surface on cellulose substrate was fabricated from the silica hydrosol functionalized with silane chemicals by a facile electrochemically assisted deposition technique. The silica hydrosol was synthesized using tetraethoxysilane (TEOS) as the precursor and sodium dodecylbenzene (SDBS) as the emulsifier under acidic conditions. The hydrophobic silane modifiers including octyltriethoxysiliane (OTES), dodecyltriethoxysiliane (DTES) and isooctyltriethoxysiliane (iso‐OTES) and the silane‐coupling agent γ‐mercaptopropyltriethoxysilane (MPTES) were used to dope the silica hydrosol for preparing durable hydrophobic cellulose surface. The cellulose surface modified with silane modifier iso‐OTES exhibited the best hydrophobicity with water contact angle of 162.3 ± 0.5° due to its non‐polar and hydrolytically stable of Si(C8H17) groups. The addition of silane‐coupling agent MPTES containing the SH group led to good durability of hydrophobicity with water contact angle of 130.0 ± 1.2° after 20 washing times. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42733.
Study on the poly(3‐hydroxybutyrate‐co−4‐hydroxybutyrate)‐based composites toughened by synthesized polyester polyurethane elastomer
Authors: Su Tianxiang , Zhang Rui , Wang Jianjian , Shao Wei , Hu Yuan
Published: July 2015

In this study, polycaprolactone(PCL)‐based polyurethane (PU) elastomer containing 45 wt % hard segment component was synthesized and characterized by fourier transform infrared spectroscopy, gel permeation chromatography, and X‐ray diffraction. As a toughening agent, the as‐synthesized PU was incorporated into biodegradable poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) [P(3,4)HB] by solution casting to prepare P(3,4)HB/PU composites. The microstructure and properties of P(3,4)HB/PU composites were investigated using transmission electron microscopy, X‐ray diffraction, tensile testing, scanning electron microscopy, differential scanning calorimetry, thermogravimetric analysis, and activated sludge degradation testing. The results show that PU can disperse well in a P(3,4)HB matrix. The elongation at break of P(3,4)HB/PU composites is remarkably increased while the yield strength and elastic modulus are decreased with an increase in PU content. At the same time, it is found that the fracture characteristic of P(3,4)HB is obviously transformed from brittleness into ductility with a gradual increase in PU loading. Moreover, the thermal stability of P(3,4)HB/PU composites is significantly improved compared with that of pure P(3,4)HB. In addition, the biodegradation rate of P(3,4)HB/PU composites is evidently reduced with the increase of PU content in the activated sludge degradation testing. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42740.
Electrochemical Label‐Free Nucleotide Sensors
Authors: Aoki Hiroshi
Published: July 2015

Numerous researchers have devoted a great deal of effort over the last few decades to the development of electrochemical oligonucleotide detection techniques, owing to their advantages of simple design, inherently small dimensions, and low power requirements. Their simplicity and rapidity of detection makes label‐free oligonucleotide sensors of great potential use as first‐aid screening tools in the analytical field of environmental measurements and healthcare management. This review article covers label‐free oligonucleotide sensors, focusing specifically on topical electrochemical techniques, including intrinsic redox reaction of bases, conductive polymers, the use of electrochemical indicators, and highly ordered probe structures.
The Mixed Robust /FTS Control Problem Analysis and State Feedback Control
Authors: Amato Francesco , Cosentino Carlo , Tommasi Gianmaria De
Published: July 2015

In this paper we deal with the mixed 
/finite‐time stability control problem. More specifically, given an open loop uncertain linear system, we provide a necessary and sufficient condition for quadratic input‐output finite‐time stability with an 
bound. Exploiting this result we also give a sufficient condition to solve the related synthesis problem via state‐feedback. The property of quadratic input‐output finite‐time stability with an 
bound implies that the system under consideration satisfies an 
performance bound between the disturbance input and the controlled output and, at the same time, is input‐output finite‐time stable for all admissible uncertainties. This condition requires the solution of a feasibility problem constrained by a pair of differential linear matrix inequalities (LMIs) coupled with a time‐varying LMI. The proposed technique is illustrated by means of both a numerical and a physical example.
Hα line measurements from ten diffuse galactic sources using the DEFPOS facility
Authors: Sahan M. , Oflaz F. M. , Yegingil I. , Tel E.
Published: July 2015

The hydrogen Balmer‐α emission line spectrum of ten diffuse ionization sources in the Milk Way – NGC 40 (WC8), NGC 2022, NGC 6210, NGC 6618 (M17, Sh2‐45), NGC 6720 (M57), NGC 6781, NGC 6888 (Sh2‐105), NGC 6992 (Sh2‐103), NGC 7635 (Sh2‐162,) and IC 1848 (Sh2‐199) – has been investigated using a dual etalon Fabry‐Pérot optical spectrometer (DEFPOS) aatached to the 150 cm RTT150 telescope at TUBITAK National Observatory (TUG, Antalya, Turkey: 36° 51′ N; 30° 20′ E; elevation: 2547 m). All of our galactic Hα observations discussed in this paper were carried out during the nights of 2013 June 21–24 with exposure time of 3600 s. As main results the intensity, the full width at half maximum, and the radial velocity with respect to the LSR have been determined for each data set. The intensities, the radial velocities, and the line widths of the Hα emission line vary from 59.15 to 8923.44 R, –46.72 to +54.07 km s–1, and 31.4 to 48.01 km s–1, respectively. The radial velocities and the half‐widths of the Hii regions and planetary nebulae determined from our measurements are found tobe consistent with values given in literature, especially with those in Schneider et al. (1983) and Fich et al. (1990). (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Effect of Sc Promoter on the Performance of Co/TiO2–P25 Catalyst in Dry Reforming of Methane
Authors: Al‐Fatesh Ahmed Sadeq , Naeem Muhammad Awais , Fakeeha Anis Hamza , Abasaeed Ahmed Elhag
Published: July 2015

In the present work, the effect of scandium (Sc) promoter on the performance of Co/TiO2–P25 catalyst in dry reforming of methane has been investigated. The catalysts were prepared by the incipient wet impregnation technique. For each catalyst, the Co loading was fixed at 5 wt %, while the Sc loading was varied from 0.0 to 2.0 wt %. The experiments were carried out at atmospheric pressure in a micro tubular reactor at a temperature of 700 °C. For better understanding and comparison, the catalysts were characterized by various techniques such as Brunauer–Emmett–Teller (BET), X‐ray diffraction (XRD), H2‐temperature‐programmed reduction (TPR), CO2‐temperature‐programmed desorption (TPD), and thermogravimetric analyses (TGA). The results revealed that the promotion of Co/TiO2–P25 catalyst with Sc has a significant impact on its catalytic performance and the amount of carbon deposition. The doping of Co/TiO2–P25 catalyst with Sc improves the basicity and enhances the metal support interaction in the catalyst. At higher Sc loading, Co metal oxidation became substantial that triggered severe catalyst deactivation. Amongst all Sc‐promoted catalysts, 0.75 wt % Sc‐promoted catalyst exhibited the highest CH4 and CO2 activity with minimum deactivation.
Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry
Authors: Sinha Chandrima , Zhang Weiqiang , Moon Chang Suk , Actis Marcelo , Yarlagadda Sunitha , Arora Kavisha , Woodroofe Koryse , Clancy John P. , Lin Songbai , Ziady Assem G. , Frizzell Raymond , Fujii Naoaki , Naren Anjaparavanda P.
Published: July 2015

Cystic fibrosis (CF) is a lethal genetic disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel. F508del is the most prevalent mutation of the CFTR gene and encodes a protein defective in folding and processing. VX‐809 has been reported to facilitate the folding and trafficking of F508del‐CFTR and augment its channel function. The mechanism of action of VX‐809 has been poorly understood. In this study, we sought to answer a fundamental question underlying the mechanism of VX‐809: does it bind CFTR directly in order to exert its action? We synthesized two VX‐809 derivatives, ALK‐809 and SUL‐809, that possess an alkyne group and retain the rescue capacity of VX‐809. By using CuI‐catalyzed click chemistry, we provide evidence that the VX‐809 derivatives bind CFTR directly in vitro and in cells. Our findings will contribute to the elucidation of the mechanism of action of CFTR correctors and the design of more potent therapeutics to combat CF.
PNA Molecular Beacons Assembled by Post‐Synthetic Click Chemistry Functionalization
Authors: Wang Xiaoxiao , Hudson Robert H. E.
Published: July 2015

To avoid the tedious synthesis of functionalized peptide nucleic acid (PNA) monomers for probe development, we proposed a simple approach to modify PNA oligomers by post‐synthetic on‐resin click chemistry. PNA molecular beacons (MBs) were prepared by incorporation of azide‐containing monomers into the oligomer by automatic solid‐phase peptide synthesis and subsequent derivatization with pyrene moieties by copper‐catalyzed azide–alkyne cycloaddition. Two pyrene‐based quencher‐free PNA molecular beacons, a stemless MB and one possessing a stem–loop structure, targeting a portion of the cystic fibrosis gene, were successfully synthesized by using this method. Fluorescence studies showed that the stem–loop MB exhibited better discrimination of changes in excimer/monomer ratios as compared to the stemless MB construct.
Pulmonary tumor thrombotic microangiopathy associated with urothelial carcinoma of the urinary bladder: antemortem diagnosis by pulmonary microvascular cytology
Authors: Yamakawa Hideaki , Yoshida Masahiro , Yamada Masami , Ishikawa Takeo , Takagi Masamichi , Katagi Hiroaki , Yoshida Jun , Kosuga Tsuneharu , Kuwano Kazuyoshi
Published: July 2015

Key Clinical Message

PTTM (Pulmonary tumor thrombotic microangiopathy) is very difficult to diagnose before death. We report a case of urothelial carcinoma of the urinary bladder associated with PTTM in which an antemortem diagnosis by PMC (pulmonary microvascular cytology). PMC may represent the only chance for diagnosis and achievement of remission in PTTM.
Enhanced Catalytic Performance of Titanium Silicalite‐1 in Tuning the Crystal Size in the Range 1200–200 nm in a Tetrapropylammonium Bromide System
Authors: Zuo Yi , Liu Min , Zhang Ting , Meng Changgong , Guo Xinwen , Song Chunshan
Published: July 2015

A facile method for the size‐controllable synthesis of titanium silicalite‐1 (TS‐1) is presented. A tetrapropylammonium bromide hydrothermal system was used, and the amount of seeds (silicalite‐1 suspension) and crystallization time were tuned to control the crystal size. The crystal size could be adjusted from 200 to 1200 nm by varying the seed amount from 12 to 0.05 wt %. Crystallization time plays a less important role than the seed amount on the crystal size. TS‐1 samples with different crystal sizes were characterized and evaluated in propene epoxidation. The catalytic activity and selectivity of propene oxide are enhanced by decreasing the crystal size from 1200 to 200 nm because the diffusion limitation is eliminated gradually. The seed is significant for this system, as a lack of seeds leads to poor crystallization and low catalytic activity. The mechanism of the seed function was studied by simulating the transformation process of the seed in the TS‐1 synthesis system.
5 V‐Class Electrolytes Based on Fluorinated Solvents for Li‐Ion Batteries with Excellent Cyclability
Authors: Xia Lan , Xia Yonggao , Wang Chuanshui , Hu Huasheng , Lee Saixi , Yu Qi , Chen Huichuang , Liu Zhaoping
Published: July 2015

A novel electrochemically compatible, high‐voltage, and nonflammable electrolyte has been prepared based on a fluorinated ether with no flash point, that is, 1,1,1,3,3,3‐hexafluoroisopropyl methyl ether (HFPM). Our experimental results demonstrate that this F‐electrolyte is not only totally nonflammable in fire burning tests, but it also exhibits a remarkably high anodic stability of at least 5.5 V (vs. Li+/Li). In particular, this F‐electrolyte has good compatibility with graphite anodes. Mesocarbon microbeads/LiNi0.5Mn1.5O4 18650 batteries made with this F‐electrolyte display an excellent cycling stability with 82 % capacity retention after 200 cycles at a high cutoff voltage of 4.9 V, confirming their potential as high‐voltage lithium‐ion batteries with enhanced safety and longevity.
A Highly Effective Ruthenium System for the Catalyzed Dehydrogenative Cyclization of Amine–Boranes to Cyclic Boranes under Mild Conditions
Authors: Wallis Christopher J. , Alcaraz Gilles , Petit Alban S. , Poblador‐Bahamonde Amalia I. , Clot Eric , Bijani Christian , Vendier Laure , Sabo‐Etienne Sylviane
Published: July 2015

We recently disclosed a new ruthenium‐catalyzed dehydrogenative cyclization process (CDC) of diamine–monoboranes leading to cyclic diaminoboranes. In the present study, the CDC reaction has been successfully extended to a larger number of diamine–monoboranes (4–7) and to one amine–borane alcohol precursor (8). The corresponding NB(H)N‐ and NB(H)O‐containing cyclic diaminoboranes (12–15) and oxazaborolidine (16) were obtained in good to high yields. Multiple substitution patterns on the starting amine–borane substrates were evaluated and the reaction was also performed with chiral substrates. Efforts have been spent to understand the mechanism of the ruthenium CDC process. In addition to a computational approach, a strategy enabling the kinetic discrimination on successive events of the catalytic process leading to the formation of the NB(H)N linkage was performed on the six‐carbon chain diamine–monoborane 21 and completed with a 15N NMR study. The long‐life bis‐σ‐borane ruthenium intermediate 23 possessing a reactive NHMe ending was characterized in situ and proved to catalyze the dehydrogenative cyclization of 1, ascertaining that bis σ‐borane ruthenium complexes are key intermediates in the CDC process.
Facile Assembly of Chiral Metallosquares by Using Enantiopure Tribenzotriquinacene Corner Motifs
Authors: Xu Wen‐Rong , Xia Guang‐Jie , Chow Hak‐Fun , Cao Xiao‐Ping , Kuck Dietmar
Published: July 2015

Invited for the cover of this issue are Wen‐Rong Wu, Guang‐Jie Xia, and Hak‐Fun Chow of The Chinese University of Hong Kong, Xiao‐Ping Cao of Lanzhou University and Dietmar Kuck of Bielefeld University. The image depicts how different routes can lead to the same goal. Read the full text of the article at 10.1002/chem.201501556.
ChemInform Abstract: One‐Dimensional Decavanadate Chains in the Crystal Structure of Rb4[Na(H2O)6] [HV10O28]·4H2O.
Authors: Yakubovich Olga V. , Steele Ian M. , Yakovleva Ekaterina V. , Dimitrova Olga V.
Published: July 2015

Rb4[Na(H2O)6] [HV10O28]·4H2O is prepared by hydrothermal reaction of Rb3PO4, Na2CO3, Al(OH)3, and V2O5 in the presence of a small amount of B2O3 (5 wt%) as mineralizer (autoclave, 7 MPa, 553 K, 20 d).
ChemInform Abstract: Crystal Structure of CsCrAs2O7, a New Member of the Diarsenate Family.
Authors: Bouhassine Mohamad Alem , Boughzala Habib
Published: July 2015

CsCrAs2O7 is prepared by calcination of a stoichiometric mixture of Cs2CO3, Cr2O3, and NH4H2AsO4 (porcelain crucible, 1023 K, 4 d; cooling to 923 K at a rate of 5 K/d).
ChemInform Abstract: Experimental Investigation of Phase Equilibria in Ge—Ni—Ti System.
Authors: Xie Z. Y. , Lv K. L. , Luo Y. H. , Liu H. S. , Jin Z. P.
Published: July 2015

Phase relations in the Ge—Ni—Ti ternary system are studied at 973 and 1073 K by repeated arc melting of the elements followed by annealing (evacuated quartz tubes, 973/1073 K, 100 d).
ChemInform Abstract: Controllable Synthesis of Mesoporous Peapod‐Like Co3O4@Carbon Nanotube Arrays for High‐Performance Lithium‐Ion Batteries.
Authors: Gu Dong , Li Wei , Wang Fei , Bongard Hans , Spliethoff Bernd , Schmidt Wolfgang , Weidenthaler Claudia , Xia Yongyao , Zhao Dongyuan , Schueth Ferdi
Published: July 2015

Mesoporous peapod‐like Co3O4@carbon nanotube (CNT) arrays with Co3O4 nanoparticles confined exclusively in the intratubular pores are achieved starting with the preparation of mesoporous SiO2 (SBA‐15 hard template) which is infiltrated by a furfuryl alcohol‐containing polymer solution prior to thermal degradation.
ChemInform Abstract: Planar CH3NH3PbI3 Perovskite Solar Cells with Constant 17.2% Average Power Conversion Efficiency Irrespective of the Scan Rate.
Authors: Im Sang Hyuk , et al.
Published: July 2015

Pinhole‐free MeNH3PbI3 perovskite thin films on TiO2/F‐doped SnO2 substrates are prepared by spin coating of MeNH3PbI3/DMF or CH3NH3PbI3/DMSO solutions containing HI as an additive.
ChemInform Abstract: A Battery Made from a Single Material.
Authors: Han Fudong , Gao Tao , Zhu Yujie , Gaskell Karen J. , Wang Chunsheng
Published: July 2015

A new high energy single‐material all‐solid‐state lithium ion battery is reported wherein the cathode, electrolyte, and anode consists of Li10GeP2S12 mixed with electronically conductive carbon.
ChemInform Abstract: Syntheses, Structure and Magnetic Properties of Two Vanadate Garnets Ca5M4V6O24 (M: Co, Ni).
Authors: Wang Nannan , He Zhangzhen , Cui Meiyan , Guo Wenbin , Zhang Suyun , Yang Ming , Tang Yingying
Published: July 2015

Ca5M4V6O24 (M: Co, Ni) are prepared by reaction of CaCO3, CoC2O4 or Ni(OAc)2, and V2O5 (alumina crucible, 900 resp.
ChemInform Abstract: A {Co4O4} Cubane Incorporated within a Polyoxoniobate Cluster.
Authors: Liang Zhijie , Zhang Dongdi , Ma Pengtao , Niu Jingyang , Wang Jingping
Published: July 2015

The new compound Na6K12 [H2Co8O4 (Nb6O19)4]·39H2O is hydrothermally synthesized from aqueous solutions containing K7HNb6O19, CoCl2, and NaOH (autoclave, pH = 12.5, 160 °C, 22 h) followed by the diffusion method (13% yield).
ChemInform Abstract: Highly Enantioselective Michael Addition Reactions with New Trimeric Chiral Phase Transfer Catalysts.
Authors: Beneto Arockiam Jesin , Sivamani Jayaraman , Ashokkumar Veeramanoharan , Balasaravanan Rajendiran , Duraimurugan Kumaraguru , Siva Ayyanar
Published: July 2015

Two new multi‐site phase transfer catalysts are introduced for the enantioselective Michael addition reactions of various chalcones with diethyl malonate.
ChemInform Abstract: Construction of Chiral 2‐Substituted Octahydroindoles from Cyclic Ketones and Nitroolefins Bearing only One α‐Substituent.
Authors: Han Yong , Zheng Bo , Peng Yungui
Published: July 2015

A dual catalytic system is developed following the screening of a series of chiral primary amine catalysts and chiral phosphoric acid catalysts for the Michael addition of cyclic ketones to nitro olefins bearing only one α‐substituent.
ChemInform Abstract: Organocatalyzed Asymmetric Vinylogous Michael Reactions of 3,5‐Dialkyl‐Substituted 4‐Nitroisoxazoles: A Direct Method for the Synthesis of Chiral Isoxazole Derivatives.
Authors: Zhang Yong , Wei Biaowen , Lin Hui , Cui Weirong , Zeng Xianqiang , Fan Xiaolin
Published: July 2015

Various highly functionalized chiral isoxazole derivatives are obtained in excellent enantioselectivities by direct asymmetric vinylogous Michael addition of 3,5‐dialkyl‐substituted 4‐nitroisoxazoles with α,β‐unsaturated aldehydes using a diphenylprolinol Tbs ether as organocatalyst.
ChemInform Abstract: Enantioselective Halogenative Semi‐Pinacol Rearrangement: Extension of Substrate Scope and Mechanistic Investigations.
Authors: Romanov‐Michailidis Fedor , Romanova‐Michaelides Maria , Pupier Marion , Alexakis Alexandre
Published: July 2015

A survey of the recent results of the enantioselective halogenation‐initiated semi‐pinacol rearrangement is presented.
ChemInform Abstract: N‐Functionalized Amino Acids Promoted Aerobic Copper‐Catalyzed Oxidation of Benzylic Alcohols in Water.
Authors: Zhang Guofu , Lei Jie , Han Xingwang , Luan Yuxin , Ding Chengrong , Shan Shang
Published: July 2015

Primary and secondary benzylic alcohols are converted in their corresponding aldehydes or ketones using an efficient Cu/TEMPO/N‐functionalized amino acid catalyzed aerobic alcohol oxidation system in water.
ChemInform Abstract: Acceptorless Dehydrogenative Lactonization of Diols by Pt‐Loaded SnO2 Catalysts.
Authors: Touchy Abeda Sultana , Shimizu Ken‐ichi
Published: July 2015

Various symmetric and unsymmetric diols endowed with aliphatic and aromatic substituents are transformed according to the title reaction.
ChemInform Abstract: Direct C—H Arylation of Heterocycles with Heteroaryl Chlorides Using a Bis(alkoxo)palladium Complex.
Authors: Li Yabo , Wang Jingran , Yan Beiqi , Huang Mengmeng , Zhu Yu , Wu Yusheng , Wu Yangjie
Published: July 2015

A catalytic system comprised of a bis(alkoxo)palladium complex and Xantphos is tested in the heteroarylation of 2‐methylthiophene (I) and heteroarenes (VI).
ChemInform Abstract: Access to Trifluoromethylated 4‐Alkoxy‐2‐pyrones, Pyridones and Quinolones.
Authors: Clarke Sarah L. , McGlacken Gerard P.
Published: July 2015

from the corresponding iodides using methyl fluorosulfonyldifluoroacetate (II) as the trifluoromethylating reagent
ChemInform Abstract: Decarbonylative C—C Bond‐Forming Reactions of Saccharins by Nickel Catalysis: Homocoupling and Cycloaddition.
Authors: Mi Pengbing , Liao Peiqiu , Tu Tao , Bi Xihe
Published: July 2015

Various N‐aryl saccharins can be transformed to biphenyl‐2,2′‐disulfonamides of type (II) in the presence of PBu3/Ni(cod)2 followed by treatment with TfOH.
ChemInform Abstract: Palladium‐Catalyzed Enantioselective Heck Alkenylation of Acyclic Alkenols Using a Redox‐Relay Strategy.
Authors: Patel Harshkumar H. , Sigman Matthew S.
Published: July 2015

A redox‐relay strategy to install electron‐deficient alkenyl groups in high enantioselectivity at various distances to a carbonyl group is developed.
ChemInform Abstract: A Practical Synthesis of Trifluoromethyl Alkyl Ketones.
Authors: Yang Dongmei , Zhou Yuhan , Song Yuming , Qu Jingping
Published: July 2015

i‐Pr‐and t‐Bu alkyl ketones are found to be competent reaction partners for easy trifluoromethyl ketone separation from the product mixtures.
ChemInform Abstract: Lanthanide‐Catalyzed Oxidative C—O Coupling of 1,3‐Dicarbonyl Compounds with Diacyl Peroxides.
Authors: Terent'ev Alexander O. , Vil' Vera A. , Nikishin Gennady I. , Adam Waldemar
Published: July 2015

Oxygen‐functionalized adducts are efficiently and conveniently obtained.
ChemInform Abstract: A Mild CuCl‐Catalyzed Glaser‐Type Homocoupling Reaction: Air Oxidation and Room Temperature.
Authors: Chen Xi , Zhang Hailong , Chen Jinping , Gong Hang
Published: July 2015

The Glaser‐type homocoupling reaction of terminal alkynes gives the corresponding 1,3‐diynes under simple conditions.
ChemInform Abstract: Synthesis of Polysubstituted Iodobenzene Derivatives from Alkynylsilanes and 1,3‐Dienes via Diels—Alder/Oxidation/Iodination Reaction Sequence.
Authors: Moeckel Robert , Hilt Gerhard
Published: July 2015

Careful elaboration of the reaction conditions allows for the regioselective generation of trimethylsilyl substituted dihydroaromatic derivatives via Diels‐Alder reaction of alkynyltrimethylsilanes and substituted 1,3‐dienes.
ChemInform Abstract: Bioinspired, Base‐ and Metal‐Free, Mild Decarboxylative Aldol Activation of Malonic Acid Half Thioesters under Phase‐Transfer Reaction Conditions.
Authors: Bew Sean P. , Stephenson G. Richard , Rouden Jacques , Ashford Polly‐Anna , Bourane Manuel , Charvet Agathe , Dalstein Virginie M. D. , Jauseau Raphael , Hiatt‐Gipson G. D. , Martinez‐Lozano Luis A.
Published: July 2015

A general, base and metal‐free protocol is presented for a bioinspired aldol reaction under mild and neutral conditions.
ChemInform Abstract: Chiral Ammonium Hypoiodite‐Catalyzed Enantioselective Oxidative Dearomatization of 1‐Naphthols Using Hydrogen Peroxide.
Authors: Uyanik Muhammet , Sasakura Niiha , Kaneko Erina , Ohori Kento , Ishihara Kazuaki
Published: July 2015

A highly enantioselective oxidative dearomatization of 1‐naphthol derivatives (Kita spirolactonization) catalyzed by chiral hypoiodite species prepared in situ from chiral quaternary ammonium iodide in the presence of hydrogen peroxide is reported.
ChemInform Abstract: Substituent Effect on the Diastereoselectivity in the Sulfa‐Staudinger Cycloaddition.
Authors: Yang Zhanhui , Xu Jiaxi
Published: July 2015

The substituent effects of both sulfonyl chlorides and imines in the title reaction are systematically investigated and rationalized.
ChemInform Abstract: One‐Pot Highly Diastereoselective Annulation to N‐Unprotected Tetrasubstituted 2‐Pyrrolines.
Authors: Meninno Sara , Capobianco Amedeo , Peluso Andrea , Lattanzi Alessandra
Published: July 2015

Unprotected tetrasubstituted 2‐pyrrolines (III) are obtained, exploiting a Michael addition/deprotection/cyclization/tautomerization sequence.
ChemInform Abstract: Use of a New Spirophosphine to Achieve Catalytic Enantioselective [4 + 1] Annulations of Amines with Allenes to Generate Dihydropyrroles.
Authors: Kramer Soeren , Fu Gregory C.
Published: July 2015

An effective method for the nucleophile‐catalyzed method for the [4 + 1] annulation of sulfonamides with trisubstituted allenes to yield dihydropyrroles with good enantioselectivities is developed.
ChemInform Abstract: Synthesis and Applications of a New Epoxy‐Isoindolinone.
Authors: Chou Shang‐Shing P. , Hsu Sung‐Lin
Published: July 2015

The new epoxyisoindolinone (V) is stereoselectively synthesized from bicyclic sulfone (II) and transformed into a series of interesting products, including new compound (X) having an interesting 6‐azabicyclooctane skeleton, via nucleophilic substitution reactions.
ChemInform Abstract: Chiral 2‐Aminopyrimidin‐4(1H)‐one Derivative as the Novel Bifunctional Organocatalyst: Enantioselective Aldol Reaction of Isatins with Ketones.
Authors: Lu Hongfu , Bai Jingtao , Xu Jianyu , Yang Ting , Lin Xichen , Li Jian , Ren Feng
Published: July 2015

20 examples with 60‐94% e.e.
ChemInform Abstract: Novel Approach to Bis(indolyl)methanes: De novo Synthesis of 1‐Hydroxyiminomethyl Derivatives with Anticancer Properties.
Authors: Grosso Carla , Cardoso Ana Lucia , Lemos Americo , Varela Joao , Rodrigues Maria Joao , Custodio Luisa , Barreira Luisa , Pinho e Melo Teresa M. V. D.
Published: July 2015

A series of title compounds is prepared and the cytotoxic properties of some of them are evaluated against 8 tumoural cell lines.
ChemInform Abstract: Organocatalytic Atroposelective Formal Diels—Alder Desymmetrization of N‐Arylmaleimides.
Authors: Eudier Florine , Righi Paolo , Mazzanti Andrea , Ciogli Alessia , Bencivenni Giorgio
Published: July 2015

A newly developed organocatalytic atroposelective formal Diels—Alder desymmetrization reaction is applied for the synthesis of new succinimides bearing a chiral axis and three stereogenic centers.
ChemInform Abstract: Iridium‐Catalyzed Intramolecular Enantioselective C—H Alkylation at the C‐2 Position of N‐Alkenylindoles.
Authors: Shibata Takanori , Ryu Naoto , Takano Hideaki
Published: July 2015

Intramolecular enantioselective alkylation of N‐alkenylindoles proceeds via C—H bond cleavage at the C‐2 position in the presence of a cationic iridium catalyst with a diphosphine ligand.
ChemInform Abstract: Direct Construction of Fused Indoles by Gold‐Catalyzed Cascade Cyclization of Conjugated Diynes.
Authors: Naoe Saori , Saito Tatsuo , Uchiyama Masanobu , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki
Published: July 2015

A novel Gold‐catalyzed cyclization of conjugated diynes (I) bearing an ortho‐hydroxyethylamine substituent yields oxepino[1,7‐a]indole derivatives (II) preferentially.
ChemInform Abstract: Copper‐Catalyzed Aerobic Cascade Cycloamination and Acyloxylation: A Direct Approach to 4‐Acyloxy‐1H‐pyrazoles.
Authors: Ding Zhengwei , Tan Qitao , Gao Mingchun , Xu Bin
Published: July 2015

A novel protocol for the regioselective synthesis of multisubstituted 4‐acyloxy‐pyrazoles such as (III) and (V) in a single step from hydrazones and carboxylic acids is reported.
ChemInform Abstract: Oleic Acid: A Benign Broensted Acidic Catalyst for Densely Substituted Indole Derivative Synthesis.
Authors: Ganesan Asaithampi , Kothandapani Jagatheeswaran , Nanubolu Jagadeesh Babu , Ganesan Subramaniapillai Selva
Published: July 2015

The developed method allows for the preparation of functionalized 4H‐chromene, spirooxindole, spiro[indoline‐3,4′‐pyrano[2,3‐c]pyrazole], and bis(indolyl)methane derivatives.
ChemInform Abstract: Synthesis of 5‐Iodo‐4H‐1,3‐oxazine‐4‐ones Through a [3 + 3] Reaction of Amides and Propiolates Induced by N‐Iodosuccinimide (NIS) and Cu(CF3SO3)2.
Authors: Li Chen , Liu Nan , Qi Qing‐Rong , Chen Yue , He Ling
Published: July 2015

A new synthesis of fully substituted 5‐iodo‐4H‐1,3‐oxazine‐4‐ones is achieved by reaction of propiolates (I) with simple amides.
ChemInform Abstract: Copper‐Catalyzed Tandem Reactions of 2‐Iodobenzamides with Sodium Azide: An Efficient Synthesis of [1,2,3]Triazolo[1,5‐a][1,4]‐benzodiazepin‐6(5H)‐ones.
Authors: Chen Wanli , Li Haitao , Gu Xiaoling , Zhu Yinghong
Published: July 2015

The title compounds are efficiently obtained by reaction of 2‐iodobenzamides with a propargyl group on the nitrogen atom moiety and sodium azide under mild reaction conditions.
ChemInform Abstract: Diorganodichalcogenides and Their Intramolecular Cyclization Reactions.
Authors: Poellnitz Alpar , Silvestru Anca
Published: July 2015

The reaction of dichalcogenides (I) with benzylamine (II) affords compounds (III), products of an unexpected oxidative intramolecular cyclization.
ChemInform Abstract: Reactions of Alkynyl‐ and 1,1′‐Dialkynylferrocenes with Tetracyanoethylene — Unanticipated Addition at the Less Electron‐Rich of Two Triple Bonds.
Authors: Krausse Nico , Kielmann Marc , Ma Jingxiang , Butenschoen Holger
Published: July 2015

The reaction of ferrocenyl substituted internal alkynes with tetracyanoethylene yields adducts of type (III) in generally good to excellent yields.
ChemInform Abstract: Structures and Bioactivities of Xenicanes from an Okinawan Soft Coral Xenia sp.
Authors: Ueda Katsuhiro , Maarisit Wilmar , Yano Kentaro , Miyazato Tomofumi , Roy Prodip K. , Taira Junsei
Published: July 2015

Together with four known xenicanes, xenicanes (I) and (II) are isolated.
ChemInform Abstract: Room Temperature N‐Arylation of Amino Acids and Peptides Using Copper(I) and β‐Diketone.
Authors: Sharma Krishna K. , Sharma Swagat , Kudwal Anurag , Jain Rahul
Published: July 2015

A high yielding, general method for the N‐arylation of zwitterionic amino acids, amino acid esters, and peptides is described.
ChemInform Abstract: Carapanolides M—S from Seeds of Andiroba (Carapa guianensis, Meliaceae) and Triglyceride Metabolism‐Promoting Activity in High Glucose‐Pretreated HepG2 Cells.
Authors: Inoue Takanobu , Matsui Yuuki , Kikuchi Takashi , Yamada Takeshi , In Yasuko , Muraoka Osamu , Sakai Chie , Ninomiya Kiyofumi , Morikawa Toshio , Tanaka Reiko
Published: July 2015

Seven novel limonoids, e.g. mexicanolide‐type carapanolides R (Ia) and S (Ib) are isolated from the oil of Carapa guianensis.
ChemInform Abstract: Xanthones from the Fermentation Products of an Endophytic Fungus Phomopsis sp.
Authors: Ma Yinhai , et al.
Published: July 2015

isolation, structure determination and anticancer activities of new xanthones, dalienxanthenones A‐C(I), and three known analogues
ChemInform Abstract: III—V Nanowires: Synthesis, Property Manipulations, and Device Applications
Authors: Fang Ming , Han Ning , Wang Fengyun , Yang Zai‐Xing , Yip SenPo , Dong Guofa , Hou Jared J. , Chueh Yulun , Ho Johnny C.
Published: July 2015

Review: 61 refs.
ChemInform Abstract: Organonickel(IV) Chemistry: A new Catalyst
Authors: Mitra Raja , Poerschke Klaus‐Richard
Published: July 2015

Review: 22 refs.
ChemInform Abstract: Aerobic Oxidation Catalysis with Air or Molecular Oxygen and Ionic Liquids
Authors: Gunasekaran Nanjappan
Published: July 2015

Review: 109 refs.
ChemInform Abstract: Porous Ionic Liquids: Synthesis and Application
Authors: Zhang Shiguo , Dokko Kaoru , Watanabe Masayoshi
Published: July 2015

Review: 48 refs.
ChemInform Abstract: Copper‐Catalyzed Cross‐Coupling Reactions for C—P Bond Formation
Authors: Zhang Hui , Zhang Xue‐Yan , Dong Dao‐Qing , Wang Zu‐Li
Published: July 2015

Review: [40 refs.
ChemInform Abstract: Phosphite Ligands in Ru‐Based Olefin Metathesis Catalysts
Authors: Bantreil Xavier , Cazin Catherine S. J.
Published: July 2015

Review: 77 refs.
ChemInform Abstract: Dye‐Functionalized Polymers via Ring Opening Metathesis Polymerization: Principal Routes and Applications
Authors: Hollauf Manuel , Trimmel Gregor , Knall Astrid‐Caroline
Published: July 2015

Review: 113 refs.
ChemInform Abstract: Rhodium‐Catalyzed Hydroformylation in Fused Azapolycycles Synthesis
Authors: Settambolo Roberta
Published: July 2015

Review: 166 refs.
ChemInform Abstract: Water in N‐Heterocyclic Carbene‐Assisted Catalysis
Authors: Levin Efrat , Ivry Elisa , Diesendruck Charles E. , Lemcoff N. Gabriel
Published: July 2015

Review: 460 refs.
ChemInform Abstract: Quasi‐Aromaticity — What Does it Mean?
Authors: Krygowski Tadeusz M. , Bankiewicz Barbara , Czarnocki Zbigniew , Palusiak Marcin
Published: July 2015

Review: 167 refs.
Liver fibrosis: Therapeutic armory 40 years on
Authors: Iredale John P. , Sci F Med , Pellicoro Antonella
Published: July 2015

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Molecular markers and pathway analysis of colorectal carcinoma in the Middle East
Authors: Beg Shaham , Siraj Abdul K. , Prabhakaran Sarita , Bu Rong , Al‐Rasheed Maha , Sultana Mehar , Qadri Zeeshan , Al‐Assiri Mohammed , Sairafi Rami , Al‐Dayel Fouad , Al‐Sanea Nasser , Uddin Shahab , Al‐Kuraya Khawla S.
Published: July 2015

BACKGROUND

Colorectal cancer (CRC) is one of the most common cancers in the world. A newly proposed integrated pathway comprising traditional, alternate, and serrated pathways by genetic and epigenetic factors was defined recently and hypothesized to play a role in the pathogenesis of CRC; however, to the authors' knowledge, there is a paucity of information regarding these proposed molecular pathways in different ethnic groups.

METHODS

Molecular characterization of 770 CRC specimens was performed for microsatellite instability, BRAF, and KRAS by polymerase chain reaction and 500 cases for CpG island methylator phenotype (CIMP) high phenotype by MethyLight technology. Tumors were assigned to different molecular pathways and examined for clinicopathological correlation and survival analysis.

RESULTS

The traditional pathway constituted 33.4% of CRC cases, the alternate pathway comprised 11.6%, and the serrated molecular pathway accounted for only 0.8% of Middle Eastern CRC cases. Approximately 54.2% of CRC cases did not qualify to fit into any pathway and thus were designated as an unassigned group. Molecular pathways were found to be significantly associated with tumor site and grade. A subset of cases with an uncategorized pathway demonstrated a significant survival difference (P = .0079).

CONCLUSIONS

The serrated pathway was found to account for a very low percentage of the CRC patient cohort in the current study. The unassigned group accounted for the majority of Middle Eastern CRC cases, and therefore methods of CRC pathway analysis might not be applicable to this ethnic group. The current study demonstrates the need to unravel the molecular genetic basis of this disease to further subcategorize these CRC cases. It also identifies a need for further studies on different populations for a better understanding of their exact role and incidence. Cancer 2015;121:3799–3808. © 2015 American Cancer Society.
Uncertainty quantification in virtual surgery hemodynamics predictions for single ventricle palliation
Authors: Schiavazzi D. E. , Arbia G. , Baker C. , Hlavacek A. M. , Hsia T. Y. , Marsden A. L. , Vignon‐Clementel I. E. , of Congenital Hearts Alliance (MOCHA) Investigators The Modeling
Published: July 2015

The adoption of simulation tools to predict surgical outcomes is increasingly leading to questions about the variability of these predictions in the presence of uncertainty associated with the input clinical data. In the present study, we propose a methodology for full propagation of uncertainty from clinical data to model results that, unlike deterministic simulation, enables estimation of the confidence associated with model predictions. We illustrate this problem in a virtual stage II single ventricle palliation surgery example. First, probability density functions (PDFs) of right pulmonary artery (PA) flow split ratio and average pulmonary pressure are determined from clinical measurements, complemented by literature data. Starting from a zero‐dimensional semi‐empirical approximation, Bayesian parameter estimation is used to find the distributions of boundary conditions that produce the expected PA flow split and average pressure PDFs as pre‐operative model results. To reduce computational cost, this inverse problem is solved using a Kriging approximant. Second, uncertainties in the boundary conditions are propagated to simulation predictions. Sparse grid stochastic collocation is employed to statistically characterize model predictions of post‐operative hemodynamics in models with and without PA stenosis. The results quantify the statistical variability in virtual surgery predictions, allowing for placement of confidence intervals on simulation outputs. Copyright © 2015 John Wiley & Sons, Ltd.
The DEEP Project An alternative approach to heterogeneous cluster‐computing in the many‐core era
Authors: Eicker Norbert , Lippert Thomas , Moschny Thomas , Suarez Estela ,   for the DEEP project
Published: July 2015

Homogeneous cluster architectures, which used to dominate high‐performance computing (HPC), are challenged today by heterogeneous approaches utilizing accelerator or co‐processor devices. The DEEP (Dynamical Exascale Entry Platform) project is implementing a novel architecture for HPC, in which a standard HPC cluster is directly connected to a so‐called ‘Booster’: a cluster of many‐core processors. By these means heterogeneity is organized differently as in today's standard approach, where accelerators are added to each node of the cluster. In order to adapt application codes to this Cluster‐Booster architecture as seamless as possible, DEEP has developed a complete programming environment. It integrates the offloading functionality given by the Message Passing Interface standard with an abstraction layer based on the task‐based OmpSs programming paradigm. This paper presents the DEEP project with an emphasis on the DEEP programming environment. Copyright © 2015 John Wiley & Sons, Ltd.
Bio‐inspired cost‐aware optimization for data‐intensive service provision
Authors: Wang Lijuan , Shen Jun , Luo Junzhou
Published: July 2015

The use of Big Data and the development of cloud computing have led to greater dependence on data‐intensive services. Each service may actually request or create a large amount of data sets. The scope, number, and complexity of data‐intensive services are all set to soar in the future. To compose these services will be more challenging. Issues of autonomy, scalability, adaptability, and robustness, become difficult to resolve. Bio‐inspired algorithms can overcome the new challenging requirements of data‐intensive service provision. It is useful for the provision of data‐intensive services to explore key features and mechanisms of biological systems and accordingly to add biological mechanisms to services. In this paper, we will discuss single‐objective and multi‐objective data‐intensive service provision problems based on bio‐inspired algorithms. Further, we will propose an ant‐inspired negotiation approach. Finally, this paper points out future research topics. Copyright © 2015 John Wiley & Sons, Ltd.
A novel application classification attack against Tor
Authors: He Gaofeng , Yang Ming , Luo Junzhou , Gu Xiaodan
Published: July 2015

Tor is a famous anonymous communication system for preserving users' online privacy. It supports TCP applications and packs upper‐layer application data into encrypted equal‐sized cells with onion routing to hide private information of users. However, we note that the current Tor design cannot conceal certain application behaviors. For example, P2P applications usually upload and download files simultaneously, and this behavioral feature is also kept in Tor traffic. Motivated by this observation, we investigate a new attack against Tor, application classification attack, which can recognize application types from Tor traffic. An attacker first carefully selects some flow features such as burst volumes and directions to represent the application behaviors and takes advantage of some efficient machine‐learning algorithm (e.g., Profile Hidden Markov Model) to model different types of applications. Then he or she can use these established models to classify target's Tor traffic and infer its application type. We have implemented the application classification attack on Tor using parallel computing, and our experiments validate the feasibility and effectiveness of the attack. We argue that the disclosure of application type information is a serious threat to Tor users' anonymity because it can be used to reduce the anonymity set and facilitate other attacks. We also present guidelines to defend against application classification attack. Copyright © 2015 John Wiley & Sons, Ltd.
SGAM: strategy‐proof group buying‐based auction mechanism for virtual machine allocation in clouds
Authors: Zhang Yonglong , Li Bin , Huang Zhiqiu , Wang Jin , Zhu Junwu
Published: July 2015

We study the cloud resource auction problem where users can bid for resource bundle containing heterogeneous types of virtual machines, and providers allocate virtual machines to their users through group price model. Compared with fixed price model, which is not always the best approach for trading resources as its economically inefficient and inflexible nature, the group price model possess the better flexibility and monetary benefits for auction participants (e.g., cloud providers and users). The proposed auction mechanism strategy‐proof group buying‐based auction mechanism, which formulates the problem of virtual machine allocation in clouds as a combinatorial auction problem, and holds some important property such as individual rationality, ex‐post budget balance, and truthfulness, meanwhile guaranteeing efficiency in both the provider's revenue and system efficiency. Extensive simulation results show that the proposed mechanism yields the allocation efficiency and computational tractability compared with the mechanism with fixed price model. Copyright © 2015 John Wiley & Sons, Ltd.
Variation of a classical fingerprint of ideal memristor
Authors: Biolek Zdeněk , Biolek Dalibor , Biolková Viera , Kolka Zdeněk
Published: July 2015

Gradual disappearance of hysteresis with increasing frequency of the exciting signal is considered a classical fingerprint of general memristive systems. The paper analyzes a special version of this fingerprint, when the value of the charge delivered within the half‐period remains constant while the frequency of the sinusoidal current is increasing. Under these conditions, the area of the pinched hysteresis loop of the ideal memristor increases with the square of the frequency. Breaking the rules of this fingerprint indicates reliably that the element analyzed is not an ideal memristor. Copyright © 2015 The Authors International Journal of Circuit Theory and Applications Published by John Wiley & Sons, Ltd.
Contrasting demographic history and gene flow patterns of two mangrove species on either side of theCentralAmericanIsthmus
Authors: Cerón‐Souza Ivania , Gonzalez Elena G. , Schwarzbach Andrea E. , Salas‐Leiva Dayana E. , Rivera‐Ocasio Elsie , Toro‐Perea Nelson , Bermingham Eldredge , McMillan W. Owen
Published: July 2015

Comparative phylogeography offers a unique opportunity to understand the interplay between past environmental events and life‐history traits on diversification of unrelated but co‐distributed species. Here, we examined the effects of the quaternary climate fluctuations and palaeomarine currents and present‐day marine currents on the extant patterns of genetic diversity in the two most conspicuous mangrove species of the Neotropics. The black (Avicennia germinans,Avicenniaceae) and the red (Rhizophora mangle, Rhizophoraceae) mangroves have similar geographic ranges but are very distantly related and show striking differences on their life‐history traits. We sampled 18 Atlantic and 26 Pacific locations forA. germinans(N = 292) andR. mangle(N = 422). We performed coalescence simulations using microsatellite diversity to test for evidence of population change associated with quaternary climate fluctuations. In addition, we examined whether patterns of genetic variation were consistent with the directions of major marine (historical and present day) currents in the region. Our demographic analysis was grounded within a phylogeographic framework provided by the sequence analysis of two chloroplasts and one flanking microsatellite region in a subsample of individuals. The two mangrove species shared similar biogeographic histories including: (1) strong genetic breaks between Atlantic and Pacific ocean basins associated with the final closure of theCentral American Isthmus (CAI), (2) evidence for simultaneous population declines between the mid‐Pleistocene and early Holocene, (3) asymmetric historical migration with higher gene flow from the Atlantic to the Pacific oceans following the direction of the palaeomarine current, and (4) contemporary gene flow between West Africa and South America following the major Atlantic Ocean currents. Despite the remarkable differences in life‐history traits of mangrove species, which should have had a strong influence on seed dispersal capability and, thus, population connectivity, we found that vicariant events, climate fluctuations and marine currents have shaped the distribution of genetic diversity in strikingly similar ways.