bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Scale Visualization Study of Water and Polymer Microsphere Flooding through Horizontal Wells in Low-Permeability Oil Reservoir
Authors: Cheng Liang , Xie Yang , Chen Jie , Wang Xiao , Luo Zhongming , Chen Guo
Published: September 2024

Our target USH reservoir in the D oilfield is characterized by “inverse rhythm” deposition with the noticeable features of “high porosity and low permeability”. The reservoir has been developed with waterflooding using horizontal wells. Due to the strong heterogeneity of the reservoir, water channeling is severe, and the water cut has reached 79%. Considering the high temperature and high salinity reservoir conditions, polymer microspheres (PMs) were selected to realize conformance control. In this study, characterization of the polymer microsphere suspension was achieved via morphology, size distribution, and viscosity measurement. Furthermore, a multi-scale visualization study of the reservoir development process, including waterflooding, polymer microsphere flooding, and subsequent waterflooding, was conducted using macro-scale coreflooding and calcite-etched micromodels. It was revealed that the polymer microspheres could swell in the high salinity brine (170,000 ppm) by 2.7 times if aged for 7 days, accompanied by a viscosity increase. This feature is beneficial for the injection at the wellbore while swelled to work as a profile control agent in the deep formation. The macro-scale coreflood with a 30 cm × 30 cm × 4.5 cm layer model with 108 electrodes installed enabled the oil distribution visualization from different perpendicular cross sections. In this way, the in situ conformance control ability of the polymer microsphere was revealed both qualitatively and quantitatively. Furthermore, building on the calcite-etched visible micro-model, the pore-scale variation of the residual oil when subjected to waterflooding, polymer microsphere waterflooding, and subsequent waterflooding was collected, which revealed the oil displacement efficiency increase by polymer microspheres directly. The pilot test in the field also proves the feasibility of conformance control by the polymer microspheres, i.e., more than 40,000 bbls of oil increase was observed in the produces, accompanied by an obvious water reduction.
Diversity of Saccharomyces cerevisiae Yeast Strains in Granxa D’Outeiro Winery (DOP Ribeiro, NW Spain): Oenological Potential
Authors: Blanco Pilar , García-Luque Estefanía , González Rebeca , Soto Elvira , Juste José Manuel M. , Cao Rafael
Published: September 2024

Yeasts play an essential role in the aroma and sensory profiles of wines. Spontaneous fermentations were carried out at the newly built winery of Granxa D’Outeiro. Yeasts were isolated from must at different stages of fermentation. Colonies belonging to Saccharomyces cerevisiae were characterised at the strain level by mtDNA-RFLPs. General chemical parameters and aroma profiles of the wines were determined using official OIV methodology and GC-MS analysis, respectively. The diversity of S. cerevisiae per fermentation ranged from 5 to 13 different strains depending on the grapevine variety. Out of 24 strains, strain B was the dominant yeast in most fermentations at different proportions, but strains D, E, and H also reached up to 25% of the total population in some fermentations. The yeast diversity was higher in the Lado fermentation than in those containing Treixadura. The chemical compositions of the wines revealed differences among them, with Loureira and Albariño wines showing the highest content of volatile compounds. The evaluation of their technological properties revealed the oenological potential of some strains of S. cerevisiae. The strains showing the best scores were selected to be used in future vintages to enhance the typicality of wines in the Granxa D’Outeiro winery.
Upgrading Denitrification by Optimal Adsorption of SCFAs from Sludge Alkaline Fermentation Liquid by Acid-Modified Sepiolite
Authors: Su Saisai , Ning Shuyun , Wu Shaobo , Duan Yanqing , Gao Yanjuan , Liu Zhihong
Published: September 2024

Sludge alkaline fermentation liquid (AFL) is a potential carbon source for biological denitrification. However, its effectiveness is limited due to the presence of nutrients and heavy metals. In this study, acid-modified sepiolite (MSEP) was used to extract short-chain fatty acids (SCFAs) from AFL under optimized conditions and then with the prepared MSEP-AFL as a carbon source for denitrification. The optimal condition with an MSEP dosage of 1.96 g/L and pH 7.93 at 30 °C was obtained based on single-factor experiments and response surface methodology (RSM). Carbon balance revealed that 96.2% of the SCFAs, including 43.7% acetate and 23.5% propionic acid, was retained in the MSEP, demonstrating its high selectivity. The adsorption process followed the pseudo-second-order kinetic and Langmuir isothermal model, indicating dominant physical adsorption on the surface or in the fiber pores. This was further supported by the changes in the morphological features and surface properties of the MSEP. In the batch nitrate utilization experiments, the prepared MSEP-AFL was proven to be efficient as a carbon source, with a nitrate removal efficiency of 88.7% and a specific denitrification rate of 8.2 mg NOx-N/g VSS·h, which was 22% higher than that of the AFL. This was due to the establishment of a delicate “release–utilization” balance. These findings contribute to our understanding of the use of AFL for denitrification.
Measuring the Effectiveness of Carbon-Aware AI Training Strategies in Cloud Instances: A Confirmation Study
Authors: Vergallo Roberto , Mainetti Luca
Published: September 2024

While the massive adoption of Artificial Intelligence (AI) is threatening the environment, new research efforts begin to be employed to measure and mitigate the carbon footprint of both training and inference phases. In this domain, two carbon-aware training strategies have been proposed in the literature: Flexible Start and Pause & Resume. Such strategies—natively Cloud-based—use the time resource to postpone or pause the training algorithm when the carbon intensity reaches a threshold. While such strategies have proved to achieve interesting results on a benchmark of modern models covering Natural Language Processing (NLP) and computer vision applications and a wide range of model sizes (up to 6.1B parameters), it is still unclear whether such results may hold also with different algorithms and in different geographical regions. In this confirmation study, we use the same methodology as the state-of-the-art strategies to recompute the saving in carbon emissions of Flexible Start and Pause & Resume in the Anomaly Detection (AD) domain. Results confirm their effectiveness in two specific conditions, but the percentage reduction behaves differently compared with what is stated in the existing literature.
Study on Response Time Hysteresis Model of Smoke Detectors in Aircraft Cargo Compartment
Authors: Cui Hongwei , Ruan Chenran , Wang Shengdong , Lu Song , Zhang Heping , Wang Minqiang
Published: September 2024

A fire in the cargo compartment has a major impact on civil aviation flight safety, and according to the airworthiness clause of the CCAR-25, the detector must sound an alarm within 1 min of a fire in the cargo compartment. As for the cargo compartment of large transport aircrafts, the internal space is high and open, and the smoke movement speed becomes slower with significant cooling in the process of diffusion. Hysteresis can occur in smoke detectors because of their internal labyrinth structure, which causes the detector’s internal and external response signals to be out of sync. This research employs a numerical simulation to examine the detector response parameters under an ambient wind speed of 0.1–0.2 m/s and fits a Cleary two-stage hysteresis model, where τ1= 0.09u−1.43 and τ2= 0.67u−1.59. Finally, multiple full-scale cargo cabin experiments were conducted to validate the prediction model. The results show that the model’s predicted alarm range is 43.1 s to 49.0 s, and the actual alarm time obtained by the experiment falls within this interval, confirming the model’s accuracy and providing theoretical support for the structural design and layout of the aircraft cargo cabin smoke detector.
Experimental Analysis of Ceiling Temperature Distribution in Sloped Integrated Common Services Tunnels
Authors: Li Linjie , Wu Guang , Wu Zhaoguo , Huang Huixian , Zhang Haibing , Gao Zihe
Published: September 2024

In this study, a 1/10 reduced-scale model tunnel with one end closed was constructed to investigate maximum temperature profiles beneath the tunnel ceiling during fire events. By varying the heat release rates (HRRs) and tunnel slopes (0%, 2%, 5%, and 6%) and measuring horizontal temperatures longitudinally along the tunnel ceiling, the effects of these parameters were systematically examined. The findings reveal that the distribution of maximum temperatures within a one-end-closed tunnel can be categorized into three distinct regions: far-field, transition, and near-field regions. Notably, milder tunnel slopes correspond to an elevated maximum temperature beneath the ceiling. By employing dimensional analysis, two prediction models were formulated to forecast maximum temperatures beneath the ceiling for fire sources located in the far-field and near-field regions, respectively. These predictive models were validated against experimental data, demonstrating favorable agreement. This study enhances our understanding of the impact of tunnel slope on temperature distribution during fire events in one-end-closed tunnels. Furthermore, the prediction models developed offer practical tools for assessing and mitigating fire risks in such tunnel configurations.
Discovery of Methyl-End Desaturases in Razor Clam Sinonovacula constricta (Lamarck 1818) and Their Spatio-Temporal Expression
Authors: Chen Xinyi , Fang Xiang , Yang Dongzi , Xu Jilin , Ran Zhaoshou
Published: September 2024

Clarifying the biosynthetic pathway of the long-chain polyunsaturated fatty acids (LC-PUFA) of Sinonovacula constricta is essential for utilizing its LC-PUFA resources. Methyl-end (or “ωx”) desaturases are the rate-limiting enzymes in LC-PUFA biosynthesis, catalyzing the conversion of oleic acid to linoleic acid (LA) or LA to α-linolenic acid. However, their presence in S. constricta remains uncertain. Herein, we identified two ωx desaturase-like genes within the S. constricta genome, both located on the ninth chromosome possibly due to genome duplication. These genes exhibited nearly identical sequences, differing by only one amino acid, and each encodes a 354-residue peptide with typical ωx desaturase characteristics. Phylogenetic analysis grouped these putative ωx desaturases with similar enzymes from other invertebrates. However, when heterologously expressed in yeast, they exhibited no detectable desaturation activity. This suggests either non-functionality in yeast or extremely subtle desaturation abilities. Additionally, both genes displayed the highest expression in the inhalant siphon rather than in digestive tissues and exhibited relatively high expression throughout the development stages of S. constricta, except in zygotes. These findings suggest potential in vivo functional roles for these ωx desaturases in S. constricta. Collectively, these results significantly enrich our understanding of the repertoire of LC-PUFA biosynthetic enzymes in this important bivalve species.
Near Real-Time Estimation of Blood Loss and Flow–Pressure Redistribution during Unilateral Nephrectomy
Authors: Cowley James , Kyeremeh Justicia , Stewart Grant D. , Luo Xichun , Shu Wenmiao , Kazakidi Asimina
Published: September 2024

Radical or partial nephrectomy, commonly used for the treatment of kidney tumors, is a surgical procedure with a risk of high blood loss. The primary aim of this study is to quantify blood loss and elucidate the redistribution of blood flux and pressure between the two kidneys and the abdominal aorta during renal resection. We have developed a robust research methodology that introduces a new lumped-parameter mathematical model, specifically focusing on the vasculature of both kidneys using a non-Newtonian Carreau fluid. This model, a first-order approximation, accounts for the variation in the total impedance of the vasculature when various vessels are severed in the diseased kidney (assumed to be the left in this work). The model offers near real-time estimations of the flow–pressure redistribution within the vascular network of the two kidneys and the downstream aorta for several radical or partial nephrectomy scenarios. Notably, our findings indicate that the downstream aorta receives an approximately 1.27 times higher percentage of the redistributed flow from the diseased kidney compared to that received by the healthy kidney, in nearly all examined cases. The implications of this study are significant, as they can inform the development of surgical protocols to minimize blood loss and can assist surgeons in evaluating the adequacy of the remaining kidney vasculature.
Properties of Skin Collagen from Southern Catfish (Silurus meridionalis) Fed with Raw and Cooked Food
Authors: Zhang Qi , Hou Shufang , Liu Yanmei , Du Jia , Jia Yongkang , Yang Qiushi , Xu Tingting , Takagi Yasuaki , Li Dapeng , Zhang Xi
Published: September 2024

The southern catfish (Silurus meridionalis) is an economically important carnivorous freshwater fish in China. In this study, we compared the properties of skin collagen from southern catfish fed with raw food (RF) and cooked food (CF). The skin collagen yield in the RF group (8.66 ± 0.11%) was significantly higher than that of the CF group (8.00 ± 0.27%). SDS-PAGE, circular dichroism spectroscopy, and FTIR analyses revealed that the collagen extracted from southern catfish skin in both groups was type I collagen, with a unique triple helix structure and high purity. The thermal denaturation temperature of collagen in the RF group (35.20 ± 0.11 °C) was significantly higher than that of the CF group (34.51 ± 0.25 °C). The DPPH free radical scavenging rates were 68.30 ± 2.41% in the RF collagen and 61.78 ± 3.91% in the CF collagen, which was higher than that found in most fish collagen. Both the RF and CF groups had high ability to form fibrils in vitro. Under the same conditions, the CF group exhibited faster fibril formation and a thicker fibril diameter (p < 0.05). In addition, the RF group exhibited significantly higher expression of col1a1 compared to the CF group. These results indicated that feeding southern catfish raw food contributed to collagen production, and the collagen from these fish may have potential in biomaterial applications.
An Overview of Interactions between Goat Milk Casein and Other Food Components: Polysaccharides, Polyphenols, and Metal Ions
Authors: Ma Bohan , Al-Wraikat Majida , Shu Qin , Yang Xi , Liu Yongfeng
Published: September 2024

Casein is among the most abundant proteins in milk and has high nutritional value. Casein’s interactions with polysaccharides, polyphenols, and metal ions are important for regulating the functional properties and textural quality of dairy foods. To improve the functional properties of casein-based foods, a deep understanding of the interaction mechanisms and the influencing factors between casein and other food components is required. This review started by elucidating the interaction mechanism of casein with polysaccharides, polyphenols, and metal ions. Thermodynamic incompatibility and attraction are the fundamental factors in determining the interaction types between casein and polysaccharides, which leads to different phase behaviors and microstructural types in casein-based foods. Additionally, the interaction of casein with polyphenols primarily occurs through non-covalent (hydrogen bonding, hydrophobic interactions, van der Waals forces, and ionic bonding) or covalent interaction (primarily based on the oxidation of proteins or polyphenols by enzymatic or non-enzymatic (alkaline or free radical grafting) approaches). Moreover, the selectivity of casein to specific metal ions is also introduced. Factors affecting the binding of casein to the above three components, such as temperature, pH, the mixing ratio, and the fine structure of these components, are also summarized to provide a good foundation for casein-based food applications.
Risk Assessment of Pulegone in Foods Based on Benchmark Dose–Response Modeling
Authors: Voigt Verena , Franke Heike , Lachenmeier Dirk W.
Published: September 2024

This study presents a new risk assessment of pulegone, a substance classified as possibly carcinogenic to humans (Group 2B) by the WHO International Agency for Research on Cancer (IARC). The analysis used data from a two-year carcinogenicity studies in rats and mice conducted by the National Toxicology Program (NTP) in 2011. Because of the absence of a no-observed adverse effect level (NOAEL) in these studies, the benchmark dose (BMD) approach was employed as an alternative risk assessment method. The lowest BMD lower confidence level (BMDL) of 4.8 mg/kg b.w./day among the eight endpoints served as the point of departure for calculating an acceptable daily intake (ADI) of 48 μg/kg b.w./day. This new ADI is significantly lower than the previously established tolerable daily intake of 0.1 mg/kg b.w./day set in 1997. The analysis also considered various genotoxicity studies, which indicate that pulegone’s effects follow a nongenotoxic, thresholded mechanism. The estimated intake levels of pulegone in the European Union and USA were below the newly calculated ADI, suggesting a low health risk based on current consumption patterns.
Exploring the Diversity and Potential Use of Flower-Derived Lactic Acid Bacteria in Plant-Based Fermentation: Insights into Exo-Cellular Polysaccharide Production
Authors: Khiabani Azadeh , Xiao Hang , Wätjen Anders Peter , Tovar Miguel , Poulsen Vera Kuzina , Hansen Egon Bech , Bang-Berthelsen Claus Heiner
Published: September 2024

Isolation of new plant-derived lactic acid bacteria (LAB) is highly prioritized in developing novel starter cultures for plant-based fermentation. This study explores the diversity of LAB in Danish flowers and their potential use for plant-based food fermentation. A total of 46 flower samples under 34 genera were collected for LAB isolation. By introducing an enrichment step, a total of 61 LAB strains were isolated and identified using MALDI-TOF and 16S rRNA sequencing. These strains represent 24 species across 9 genera, predominantly Leuconostoc mesenteroides, Fructobacillus fructosus, Apilactobacillus ozensis, and Apilactobacillus kunkeei. Phenotypic screening for exo-cellular polysaccharide production revealed that 40 strains exhibited sliminess or ropiness on sucrose-containing agar plates. HPLC analysis confirmed that all isolates produced exo-cellular polysaccharides containing glucose, fructose, or galactose as sugar monomers. Therefore, the strains were glucan, fructan, and galactan producers. The suitability of these strains for plant-based fermentation was characterized by using almond, oat, and soy milk. The results showed successful acidification in all three types of plant-based matrices but only observed texture development in soy by Leuconostoc, Weissella, Lactococcus, Apilactobacillus, and Fructobacillus. The findings highlight the potential of flower-derived LAB strains for texture development in soy-based dairy alternatives.
Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment
Authors: Meshkovska Yeva , Abramov Artem , Mahira Shaheen , Thatikonda Sowjanya
Published: September 2024

Ovarian cancer (OC) ranks as the fifth most common cancer among women in the United States and globally, posing a significant health threat. Reactive oxygen species (ROS) have emerged as critical factors in the pathophysiology of this malignancy. ROS, characterized by their instability due to an unpaired electron, are involved in essential cellular functions and play a crucial role in the immune response under normal physiological conditions. However, an imbalance in ROS homeostasis, leading to excessive ROS production, results in oxidative stress (OS), which can cause indiscriminate damage to cellular structures and contribute to the pathogenesis of specific diseases, including OC. OC is primarily classified based on the originating cell type into epithelial, stromal, and germinal tumors, with epithelial tumors being the most prevalent. Despite advancements in medical technology, early detection of OC remains challenging, often leading to delayed treatment initiation. Current therapeutic approaches include surgical excision of tumor tissue, radiotherapy, and chemotherapy. While these treatments are effective in early-stage OC, high mortality rates and frequent relapse underscore the urgent need for novel diagnostic and therapeutic strategies. This review aims to elucidate the role of ROS in OC, emphasizing the potential for developing innovative diagnostic tools and treatments that target ROS-mediated pathways. Given the critical impact of early detection and effective treatment, advancing our understanding of ROS in the context of OC could significantly enhance patient outcomes.
Frailty and Loneliness in Older Adults: A Narrative Review
Authors: Gheorghe Andreea-Cristina , Bălășescu Elena , Hulea Ionela , Turcu Gabriela , Amariei Mihai Iustin , Covaciu Alin-Victor , Apostol Cătălina-Andreea , Asan Melisa , Badea Andrei-Cosmin , Angelușiu Ana-Cristina , Mihailescu-Marin Maria-Mirabela , Ion Daniela Adriana , Nedelcu Roxana Ioana
Published: September 2024

(1) Background: In a society with an advancing aging rate, medical systems are coming under pressure due to an increasing flow of older patients with multiple somatic diseases, exacerbated by their psychological and sociological backgrounds. We aimed to investigate the relationship between frailty and loneliness in older adults and to provide a holistic perspective on these concepts. Our research question was “Is there a link between the loneliness and frailty in older people?” (2) Methods: To assess the link between loneliness and frailty, we conducted a search accessing Index Medicus and PubMed; the timeframe of our research was from 2013 until 2023. Data regarding the study population, as well as loneliness and frailty assessments and approaches, were extracted. (3) Results: A positive relationship between loneliness and the appearance and progression of frailty in older adults is argued for. (4) Conclusions: Frailty and loneliness in older adults are often interconnected and can have a significant impact on their overall well-being. Early identification of frailty by assessing risk factors (including loneliness and/or social isolation) should become a standard of care for older patients. Appropriate combined interventions that effectively address both frailty and loneliness (physical exercises, psychological support, and social engagement) can promote healthier aging, prevent health deterioration, maintain independence, and reduce healthcare costs.
Opinions of Patients, Families and Healthcare Professionals on Family Involvement in the Care of Patients Hospitalized in a Moroccan University Hospital: A Cross-Sectional Observational Survey
Authors: Bahmane Zohra , Belayachi Jihane , Meknassi Nawal , Hughes Rinker Cortney , Abouqal Redouane , Madani Naoufel
Published: September 2024

Opinion surveys on family participation in care in non-Western countries are rare. This study aims to assess the opinions of patients, families, and healthcare professionals regarding family involvement in care to identify their preferences and the associated factors. A cross-sectional survey was conducted over eight months involving 717 participants, using structured questionnaires at the Acute Assessment Unit of a university hospital in Morocco. Comparative analyses examined the association between participant characteristics and the preferences of care categories. Poisson regression was applied to determine factors associated with participant preferences. Attitudes toward family participation in care were positive, with an average score of 3.62 ± 0.43 on a 4-point Likert scale. Healthcare professionals were more favorable towards family participation, with an average of 10.6 ± 2.44 types of care, compared to 7.17 ± 1.96 for families and 5.71 ± 2.16 for patients. Participants’ opinions converged on a set of simple and less technical care tasks. Factors significantly associated with patient preferences in the final adjustment model (p < 0.05) included frailty, loss of autonomy, length of stay, and regular and continuous (day and night) family presence. This study highlights the strong support of health professionals, patients, and families for family participation in care. Understanding these preferences and related factors is essential to maximize family participation and develop a model of Patient And Family Centered Care adapted to the Moroccan context.
Ethical Issues in Living Donor Kidney Transplantation: An Update from a Psychosocial Perspective
Authors: Martinelli Valentina , Lumer Estella L. L. , Chiappedi Matteo , Politi Pierluigi , Gregorini Marilena , Rampino Teresa , Peri Andrea , Pietrabissa Andrea , Fusar-Poli Laura
Published: September 2024

Living donor kidney transplantation (LDKT) currently represents the treatment of choice for patients with end-stage renal failure. LDKT is a serious event with profound psychological, interpersonal, familial, and social implications. Over the last few years, there has been an exponential growth in living donation programs involving genetically and emotionally related donors, as well as people who donate to an unrelated and unknown subject. The implementation of paired exchange programs, Samaritan donation, and preemptive transplantation raise further ethical issues, which are inextricably linked to the unique psychosocial context of both the donor and the recipient. The present narrative review aims to provide an update on the main ethical challenges related to LDKT. We conducted a comprehensive literature search in PubMed/Medline. The results of the most relevant studies were narratively synthesized from a psychosocial perspective around the four principles of biomedical ethics: autonomy, beneficence, non-maleficence, and justice. Finally, we discussed the potential future directions to provide an effective, patient-centered, and ethical psychosocial assessment and follow-up of living donors and recipients that underwent LDKT.
A Decade of Monitoring Primary Healthcare Experiences through the Lens of Inequality
Authors: Pasarín M. Isabel , Rodríguez-Sanz Maica , Berra Silvina , Borrell Carme , Rocha Kátia B.
Published: September 2024

Background: Health care is not exempt from harboring social inequalities, including in those countries with a universal public system. The objective was to ascertain whether the population’s assessment of primary care (PC) changed between 2006 and 2016, the decade that included the economic crisis of 2008, and also if it exhibited patterns of social inequality in Barcelona (Spain). Methods: This was a cross-sectional study using Barcelona Health Surveys 2006 and 2016. Samples (4027 and 3082 respectively) comprised residents in Barcelona, over 15 years old. Dependent variable: Primary Care (PC) index. Independent variables: age, social class, and birthplace. Analyses included means and percentiles of PC index, and Somers’ D test to compare the distribution of the groups. Results: Comparing 2016 with 2006, the distribution of the PC index remained in women (median of 73.3) and improved in men (from 70 to 73.3). By social class, the pattern of inequality observed in 2006 in men with perceived poor health status disappeared in 2016. Inequalities according to birthplace persisted in women, regardless of perceived health status, but disappeared in men. Conclusions: In the 10 years between which the global economic crisis occurred, the assessment of PC did not worsen, and it did improve for men, but the study points to the need for more focus on people born abroad.
Prevalence and Factors Associated with Burnout among Community Pharmacists in Saudi Arabia: Findings and Implications
Authors: Alhomoud Ibrahim S. , Alrasheedy Alian A.
Published: September 2024

Burnout has negative consequences for the well-being of healthcare professionals and for the safety of patients. The prevalence of burnout varies among health professions and practice settings and across studies. Consequently, this cross-sectional study aimed to determine the prevalence and factors associated with burnout among community pharmacists in the Qassim region, Saudi Arabia. The study used the Copenhagen Burnout Inventory (CBI) to assess the burnout. The CBI consists of three scales, including personal burnout, work-related burnout, and client-related burnout. A total of 226 community pharmacists participated in the study. Of these, 63.72% were male, and 44.25% had experience of 1–5 years as community pharmacists. The prevalence of personal burnout was 83.63%, while the prevalence of work-related burnout was 83.19%, and the prevalence of client-related burnout was 76.11%. The prevalence of burnout was higher among younger age, early-career pharmacists; staff pharmacists; pharmacists working ≥6 days per week; and those working in pharmacies with fewer pharmacy teams. Multivariable logistic regression showed that compared to five workdays, working six and seven days per week was an independent risk factor for developing personal burnout [(adjusted odds ratio (aOR) = 3.60: CI = (1.29–10.05), p = 0.014) and (aOR = 4.72: CI = (1.17–19.08), p = 0.030), respectively]. Similarly, pharmacists working in pharmacies with one or two pharmacists were at higher odds of developing personal burnout compared to others working in a larger team (aOR = 3.41: CI = (1.09–10.66), p = 0.035). For work-related burnout, working six and seven days per week was also an independent risk factor [(aOR = 5.78: CI = (1.96–17.06), p = 0.001), and (aOR = 8.38: CI = (1.99–35.27), p = 0.004, respectively)]. For client-related burnout, staff pharmacists were at higher odds of developing client-related burnout compared to pharmacy managers [(aOR = 2.28: CI = (1.01–5.14), p = 0.046)]. Overall, the prevalence of burnout is alarmingly high among community pharmacists in Saudi Arabia. Consequently, it is crucial to urgently address it through robust initiatives, strategies, and interventions that support the well-being, quality of life, and resilience of community pharmacists.
Second Victims in Industries beyond Healthcare: A Scoping Review
Authors: Conti Andrea , Sánchez-García Alicia , Ceriotti Daniele , De Vito Marta , Farsoni Marco , Tamburini Bruno , Russotto Sophia , Strametz Reinhard , Vanhaecht Kris , Seys Deborah , Mira José Joaquín , Panella Massimiliano
Published: September 2024

The second victim phenomenon (SVP) refers to workers negatively impacted by involvement in unanticipated adverse events or errors. While this phenomenon has been extensively studied in healthcare since its acknowledgment over 20 years ago, its presence and management in other high-risk industries have remained unclear. We conducted a scoping review aiming to map the SVP in non-healthcare industries, as well as to explore the available interventions or support programs addressed to help second victims (SVs). A total of 5818 unique records were identified and, after the screening process, 18 studies from eight sectors were included. All industries acknowledged the existence of the SVP, though many did not use a specific term for defining the SV. Similarities in psychological and emotional consequences were found across sectors. Support strategies varied, with the aviation sector implementing the most comprehensive programs. Self-care and peer support were the most reported interventions, while structured clinical support was not mentioned in any industry. Our review highlighted a lack of standardized terminology and industry-specific, evidence-based support interventions for the SVP outside of healthcare. Healthcare appears to be at the forefront of formally recognizing and addressing the SVP, despite traditionally learning from other high-reliability industries in safety practices. This presents opportunities for reciprocal learning and knowledge transfer between healthcare and other high-risk sectors.
Factors Associated with Older People’s Anxiety Symptom Positioning after COVID-19: Cross-Sectional Findings from a Canadian Sample
Authors: Low Gail , AliSher Anila Naz , Morero Juceli , Gao Zhiwei , Gutman Gloria , Franca Alex , von Humboldt Sofia
Published: September 2024

This study sheds light on the personal characteristics of older Canadians self-identifying as severely anxious and the coping strategies that they gravitated to mitigate their anxiety. Our studied sample consisted of 606 Canadians aged 60 and above who took part in an e-survey across all 10 of Canada’s provinces, launched in July 2022, when social distancing was lifted across the country. Participants completed a personal characteristics questionnaire, the Geriatric Anxiety Scale or GAS-10, and a checklist of everyday coping strategies for mitigating anxiety. A seemingly greater number of severely anxious Canadians were born female, self-identified as a cisgender woman, and were in their 60s and in poor to fair health. A univariate logistic regression analysis revealed that all such personal characteristics were associated with statistically significantly greater odds of experiencing severe anxiety. In our multivariate logistic regression analysis, no significant differences were observed between the sexes (AOR = 0.590, p = 0.404), and non-binary and cisgender men (AOR = 0.689, p = 0.441) and women (AOR = 0.657, p = 0.397). Nor were there statistically significant differences in the odds of experiencing severe anxiety for those living with versus without a life partner and chronic illnesses. Older Canadians experiencing severe anxiety were far more likely to normalize their fear and anxiety (AOR = 4.76, p < 0.001), challenge their worries (AOR = 5.21, p < 0.001), and to relax or meditate (AOR = 2.36, p = < 0.001). They were less inclined to decrease other sources of stress in their lives, to stay active, and to get enough sleep. We offer anticipatory guidance for mental health program planners and practitioners, and fruitful avenues of inquiry for researchers.
The Efficacy of Manual Therapy on Musculoskeletal Pain in Menopause: A Systematic Review
Authors: Espírito Santo João , Moita João , Nunes Alexandre
Published: September 2024

(1) Background: The aim of this review was to evaluate the effects of manual therapy for musculoskeletal pain in menopausal women. (2) Methods: A comprehensive search of manuscripts published from inception until 29 February 2024 was conducted on PubMed, EBSCO Information Services (EBSCOhost), Physiotherapy Evidence Database (Pedro), Web of Science, Scientific Electronic Library Online (SciELO), Cochrane Central Register of Controlled Clinical Trials, and Scopus using Medical Subject Headings (MeSH) and free terms. Randomized controlled trials (RCT) investigating the effects of manual therapy for musculoskeletal pain in postmenopausal women were included. Articles published in non-English or non-Portuguese languages, case reports, expert opinions, dissertations, conference papers, and gray literature were excluded. Studies were screened for population, musculoskeletal pain, intervention, and pain outcome by two independent reviewers using an ad hoc data extraction form. (3) Results: A total of 5 RCTs (4 with high risk of bias and 1 with low risk of bias) were included (total sample = 245), addressing thumb carpometacarpal osteoarthritis, thoracic kyphosis, chronic neck and backache, knee osteoarthritis, and sternocostal joint pain. The combined results of these studies showed improved musculoskeletal pain in menopausal women; duration of the follow-up was between 4 weeks to 6 months. Conclusions: The majority of studies included in this systematic review were effective in reducing musculoskeletal pain in menopausal women. These results come mainly from studies with a high risk of bias with small sample sizes, and the most representative follow-up period was short-term. Therefore, the results of this systematic review should be interpreted with caution.
Comparative Analysis of Korean Nasal Morphology Using Cone-Beam Computed Tomography
Authors: Lee Jeong-Hyun , Park Jong-Tae
Published: September 2024

Background/Objectives: Nasal morphology is a significant aspect of facial anatomy and is often used for forensic identification and aesthetic surgery. This study aims to compare nasal dimensions based on sex, facial index (FI), and nasal index (NI) using cone-beam computed tomography (CBCT) and 3D modeling. Methods: To observe differences in nasal dimensions by sex and analyze the relationships between facial shapes (FI) and nasal forms (NI), a total of 100 participants (50 males, 50 females) in their 20s were selected from Dankook University Dental Hospital. CBCT scans were performed, and 3D models were created using Mimics software (version 22.0). The measurement items included the alaria distance between (AL), the distance between N (nasion) and SN (subnasale), the distance between N (nasion) and PRN (pronasale), and the distance between SN (subnasale) and PRN (pronasale). A T-test was used for the sex-based analysis of the nasal dimensions, and the facial index- and nasal index-based nasal dimensions were analyzed using a one-way ANOVA with Scherffe’s post hoc test. Additionally, all the statistical analyses were performed using SPSS software (version 23.0). Results: The results indicated that males generally have larger nasal dimensions than females. Additionally, the mesoprosopic facial type (round face) showed the largest nasal dimensions in the FI classification, while the platyrrhine nasal type (broad and short nose) exhibited the largest dimensions in the NI classification. Conclusions: This study demonstrates that the nasal size varies significantly with sex, facial shape, and nasal form. The findings can contribute to forensic identification and provide valuable data for clinical practices in facial reconstruction and nasal surgery.
Quantifying Treatments as Usual and with Technologies in Neurorehabilitation of Individuals with Spinal Cord Injury
Authors: Tamburella Federica , Lorusso Matteo , Merone Mario , Bacco Luca , Molinari Marco , Tramontano Marco , Scivoletto Giorgio , Tagliamonte Nevio Luigi
Published: September 2024

Several technologies have been introduced into neurorehabilitation programs to enhance traditional treatment of individuals with Spinal Cord Injury (SCI). Their effectiveness has been widely investigated, but their adoption has not been properly quantified. The aim of this study is to assess the distribution of conventional (Treatment As Usual—TAU) and technology-aided (Treatment With Technologies—TWT) treatments conveniently grouped based on different therapeutic goals in a selected SCI unit. Data from 104 individuals collected in 29 months were collected in a custom database and categorized according to both the conventional American Impairment Scale classification and a newly developed Multifactor (MF) clustering approach that considers additional sources of information (the lesion level, the level of independence in the activities of daily living, and the hospitalization duration). Results indicated an average technology adoption of about 30%. Moreover, the MF clusters were less overlapped, and the differences in TWT adoption were more pronounced than in AIS-based clustering. MF clustering was capable of grouping individuals based both on neurological features and functional abilities. In particular, individuals with motor complete injuries were grouped together, whereas individuals with sensorimotor incomplete SCI were collected separately based on the lesion level. As regards TWT adoption, we found that in the case of motor complete SCI, TWT for muscle tone control and modulation was mainly selected (about 90% of TWT), while the other types of TWT were seldom adopted. Even for individuals with incomplete SCI, the most frequent rehabilitation goal was muscle tone modulation (about 75% of TWT), regardless of the AIS level, and technologies to improve walking ability (about 12% of TWT) and balance control (about 10% of TWT) were mainly used for individuals with thoracic or lumbar lesions. Analyzing TAU distribution, we found that the highest adoption of muscle tone modulation strategies was reported in the case of individuals with motor complete SCI (about 42% of TAU), that is, in cases when almost no gait training was pursued (about 1% of TAU). In the case of cervical motor incomplete SCI, compared to thoracic and lumbar incomplete SCI, there was a greater focus on muscle tone control and force recruitment in addition to walking training (38% and 14% of TAU, respectively) than on balance training. Overall, the MF clustering provided more insights than the traditional AIS-based classification, highlighting differences in TWT adoption. These findings suggest that a wider overview that considers both neurological and functional characteristics of individuals after SCI based on a multifactor analysis could enhance the personalization of neurorehabilitation strategies.
Analysis of Physical Activity on Mental Hyperactivity, Sleep Quality, and Bodily Pain in Higher Education Students—A Structural Equation Model
Authors: Fernández-García Rubén , Melguizo-Ibáñez Eduardo , Hernández-Padilla José Manuel , Alonso-Vargas José Manuel
Published: September 2024

The university population is at a vital stage of human development for acquiring an active lifestyle. Following this lifestyle will bring benefits in adulthood. This study seeks to analyse the relationship between physical activity and bodily pain, mental hyperactivity, and sleep quality as a function of the intensity of physical activity. A comparative, descriptive, and exploratory study is presented in a sample of 506 university students. The International Physical Activity Questionnaire, the Chronic Pain Grade Questionnaire, the Mental Hyperactivity Questionnaire, and the Pittsburgh Sleep Quality Index were used. The proposed model analyses the relationships of physical activity to bodily pain, mental hyperactivity, sleep disturbances, and time to fall asleep. The fit of the different adjustment indices is satisfactory (X2 = 0.47, df = 1, pl = 0.48, IFI = 0.99, CFI = 0.97; NFI = 0.91; RMSEA = 0.01). The relational analysis shows a positive relationship of physical activity to bodily pain (r = 0.02; p < 0.01), mental hyperactivity (r = 0.054; p < 0.01), sleep disturbances (r = 0.029; p < 0.01), and time to fall asleep (r = 0.047; p < 0.01). Multi-group structural equation analysis indicates that there are differences in the causal relationships of physical activity to sleep quality, mental hyperactivity, and bodily pain as a function of exercise intensity. The conclusion is that the intensity at which physical activity is performed plays a key role in mental and physical health.
Interdisciplinary Analysis and the Role of Experiments in Raw Materials and Technology Identification for Prehistoric Pottery in the Bistrița River Basin (Romania)
Authors: Drob Ana , Bolohan Neculai , Vasilache Viorica , Rățoi Bogdan-Gabriel , Brebu Mihai
Published: September 2024

The paper presents an interdisciplinary study based on an experimental model for investigating clay sources to identify prehistoric human behavior regarding resources. The study focuses on the Middle Bronze Age (1955/1773–1739/1614 cal. BC) settlement of Siliştea-Pe Cetățuie in eastern Romania, where archaeological materials from the Costișa and Monteoru cultures were discovered. Standard criteria for macroscopic analysis and analytical techniques, such as optical microscopy (OM), Scanning Electron Microscopy with Energy Dispersive X-ray Spectroscopy (SEM-EDX), Micro-Fourier Transform Infrared Spectroscopy (µ-FTIR), and thermal analysis (DTA and TG), were used to investigate the ceramic material from multiple points of view. The results showed that there were no significant differences between the ceramics of the two communities. Putting together the data obtained from macroscopic and physico-chemical analyses helped in partially reconstructing ancient human behaviors related to the production and use of ceramic vessels.
Effect of a Directional Electromagnetic Field on the Early Stages of Plant (Raphanus sativus and Saccharum officinarum) Growth
Authors: Jo Jeong Wook , Yang Sung Woo , Lee Gyu Won , Kim Jae Hun , Kim Ye Jin , Choi Yong-Keun , Kim Kwang Jin , Lee Hyeong-Seok , Bang Sung Won , Kim Hyung Joo
Published: September 2024

In this study, we aimed to develop a novel directional electromagnetic field (EMF) application method for promoting plant growth using a solenoid coil-based cultivation system. The emergence of plant shoots from seeds, shoot elongation, root proliferation, and plant growth hormones were monitored in the presence of a directional EMF using our solenoid coil system. To observe the effect of the directional EMF on seed germination, radish and sugarcane seedlings were cultivated in the system. At the seed germination stage, the EMF applied had no significant effect on germination or growth. However, after germination, shoot growth was sensitive to a directional EMF, as it was promoted by different conditions in a plant-species-dependent manner. The maximum growth promotion rates were 25.65% ± 4.21% and 38.57% ± 12.81% for radish and sugarcane, respectively. Similarly, plant root proliferation and indole-3-acetic acid (IAA) analyses indicated that directional EMF application was associated with root proliferation and hormone synthesis. Plant growth in the experimental system proved controllable; either growth stimulation or reduction were possible as the system operating conditions were made to vary. Our findings indicate that the application of a specific directional EMF could serve as an electrical plant stimulant (or electrical fertilizer).
Understanding the Wellbeing Needs of First Nations Children in Out-of-Home Care in Australia: A Comprehensive Literature Review
Authors: Garvey Darren , Carter Ken , Anderson Kate , Gall Alana , Howard Kirsten , Venables Jemma , Healy Karen , Bill Lea , Letendre Angeline , Dickson Michelle , Garvey Gail
Published: September 2024

Introduction: Despite the increasing overrepresentation of Aboriginal and Torres Strait Islander (hereafter respectfully referred to as First Nations) children living in out-of-home care (OOHC) in Australia, little is known about their wellbeing needs. This comprehensive literature review aimed to identify these needs and the features of care required to meet them. Methods: MEDLINE, CINAHL, Scopus, Informit, PsycINFO, and Embase databases and relevant grey literature were searched from inception to December 2023 for articles presenting qualitative accounts and perspectives relevant to the wellbeing needs of First Nations children in OOHC. These included reports from First Nations children in OOHC; First Nations adults with lived experience of OOHC; carers, caseworkers, and organizational stakeholders; and First Nations community members with relevant lived and/or professional experience. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and Braun and Clarke’s reflexive thematic analysis method for data analysis. Results: Thirty-five articles (19 peer-reviewed, 16 grey literature) met the inclusion criteria. Our analysis revealed six wellbeing needs of First Nations children in OOHC: Being seen, being heard; a sense of stability; holistic health support; social and cultural connections; culturally safe OOHC providers; and preparedness for transitioning out of care. A range of features of OOHC were also identified as critical for supporting these needs. Conclusions: Our findings suggest that First Nations children in OOHC have unique wellbeing needs in addition to safety, security, and health. Attention to the development and maintenance of social and cultural connections is an important concern that must be addressed by OOHC providers (caseworkers and organizations) and carers and supported by OOHC policy and the associated systems in Australia as part of providing culturally safe and supportive care.