bluuebunny/crossref_metadata_2025 huggingface dataset:
КОНСЕРВАТИВНАЯ ТЕРАПИЯ БОЛЕЗНИ ПЕЙРОНИ
Authors: Кривобок А. Г. , Ермилов С. Г. , Виненцов Ю. А. , Ермилов Г. И.
Published: February 2021

Целью исследования было изучение эффективности консервативной терапии у пациентов с болезнью Пейрони.

Материал и методы. Нами проведен ретроспективный анализ историй болезни и амбулаторных карт 196 пациентов с болезнью Пейрони. Возраст пациентов был от 23 до 76 лет. Продолжительность заболевания варьировала от 2 до 32 месяцев. Угол девиации полового члена колебался от 0° до 90°. Половая жизнь была затруднена или невозможна у 102 (52,04%) мужчин там, где угол искривления составлял от 45° до 90°. Количество бляшек отмечалось от одной до трех. Болевой синдром разной степени выраженности беспокоил всех больных во время эрекции. Консистенция бляшки у 137 (69,89%) пациентов была плотноэластической, у 55 (28,06%) – хрящеподобной, у 4 (2,04%) – костной консистенции.

Клиническое обследование пациентов осуществлялось в соответствии рекомендациям Европейской ассоциации урологов.

Назначалась консервативная терапия, разработанная кафедрой урологии ГОО ВПО «Донецкого национального медицинского университета имени М. Горького», на протяжении до 3-х месяцев. Консервативная терапия включала: назначение плаквенила, тамоксифена, токоферола ацетата.

Параллельно с пероральной консервативной терапией назначались физиотерапевтические методы лечения:  электрофорез с лидазой (64 ЕД) через день №20;  электрофорез с 3% раствором калия йодида через день №20 и фонофорез с 1% гидрокортизоновой мазью в область фиброзной бляшки через день №20, с частотой ультразвуковых волн 2500-3000 кГц, t=10'.

Результаты и обсуждение. Болевой синдром после лечения остался у 12 (6,1%) пациентов, что потребовало продолжения консервативной терапии более трех месяцев. Размер бляшки, который измерялся пальпаторно и при помощи ультрасонографии, после проведенной консервативной терапии уменьшился у 121 (61,7%) пациента. Полного рассасывания бляшки удалось достичь у 43 (21,9%) пациентов. Угол искривления полового члена во время эрекции уменьшился у 152 (77,6%) пациентов, остался без изменений у 31 (15,8%) и увеличился у 13 (6,6%) пациентов. Улучшение эрекции наблюдалось в 167 (85,2%) наблюдениях. У 44 (22,4%) пациентов эффекта от проводимой консервативной терапии не было, что послужило показанием к хирургическому лечению.

Выводы. Болезнь Пейрони тяжело поддается консервативному лечению, и основной его целью можно считать остановку процесса гиалинизации и оссификации структур белочной оболочки. Комплекс консервативной терапии, разработанный кафедрой урологии ГОО ВПО «Донецкого национального медицинского университета имени М. Горького», позволяет добиться удовлетворительных результатов при воспалительной стадии заболевания. В стадии стабилизации процесса необходимо хирургическое лечение.
ПЕРВЫЙ ОПЫТ РОДОРАЗРЕШЕНИЯ БОЛЬНОЙ МУКОВИСЦИДОЗОМ В РЕСПУБЛИКЕ МОРДОВИЯ
Authors: Дьячкова А. А. , Ледяйкина Л. В. , Сысолятина О. А.
Published: February 2021

В статье описывается первый положительный опыт беременности и родоразрешения здоровым мальчиком больной муковисцидозом в Республике Мордовия. Проанализированы особенности ведения беременности и родов при муковисцидозе.
ФАКТОРЫ РИСКА ОСЛОЖНЕНИЙ ОГНЕСТРЕЛЬНЫХ ПЕРЕЛОМОВ ДЛИННЫХ КОСТЕЙ НИЖНЕЙ КОНЕЧНОСТИ
Authors: Оприщенко А. А. , Коктышев И. В. , Штутин А. А.
Published: February 2021

Цель: выявление ряда факторов риска развития местных осложнений огнестрельных переломов нижних конечностей.

Материал и методы. Проведен анализ материалов лечения 364 раненых с огнестрельными переломами длинных костей нижней конечности. Раненые были ретроспективно разделены на две группы: 1 группа с неосложненным и 2 группа – с осложненным течением. Изучали демографические и соматометрические характеристики, механизм ранения, объем оказания помощи на догоспитальном этапе. Тяжесть состояния и тяжесть ранения оценивали по шкалам ВПХ. Анализировали время начала и объем специализированной помощи, сроки выполнения, характер и число оперативных вмешательств. В качестве результирующих показателей принимали наличие и вид раневых осложнений, длительность пребывания в стационаре, наличие и характер поздних осложнений.

Результаты. Пулевые ранения наблюдались у 12% раненых 1 группы и 22% раненых 2 группы; осколочные – 82% и 57%, минно-взрывные – 6% и 21% соответственно. Установлена взаимосвязь между ошибками помощи на догоспитальном этапе и развитием осложнений: отсутствие транспортной иммобилизации наблюдалось в 1 группе в 18%, а во 2-й – в 48% наблюдений; отсутствие асептической повязки – 22% и 32%; отсутствие медикаментозной, в том числе инфузионной, терапии – 27% и 74%, ошибки в применении турникета – 31% и 51% соответственно. Информативным показателем выявилась продолжительность шока. В группе 1 продолжительность шока составила 1,2±0,3ч [0,8 – 2,5], в то время как в группе 2 – 3,5±0,4ч [2,5 – 5,6] ( p<0,05) . Установлена корреляция между сроком начала операции и развитием осложнений (r-0,56, p<0,05), а так же продолжительностью операции и риском развития осложнений (r-0,67, p<0,05).

Заключение. основными факторами риска развития осложнений огнестрельных переломов конечностей представляются: механизм ранения, продолжительность травматического шока, качество догоспитальной помощи, сроки и объем ранней специализированной помощи. Роль локальных характеристик повреждения требует дальнейшего изучения.
СРАВНИТЕЛЬНЫЙ АНАЛИЗ ТРАДИЦИОННЫХ И МАЛОИНВАЗИВНЫХ МЕТОДИК ЛЕЧЕНИЯ ХОЛЕДОХОЛИТИАЗА
Authors: Антонюк О. С. , Шаповалов И. Н. , Голубицкий К. О. , Ярощак С. В. , Веселый В. Я. , Власов Е. И.
Published: February 2021

Одной из самых актуальных проблем современной медицины является желчнокаменная болезнь. В подавляющем большинстве случаев продолжающиеся жалобы пациентов, перенесших холецистэктомию, обусловлены недиагностированными до и/или во время операции изменениями гепатикохоледоха и БСДК. Объектом исследования стали 117 пациентов с холецистохоледохолитиазом которые перенесли традиционные оперативные вмешательства, лапароскопические методики с использованием гольмиевого лазера и эндоскопические пособия. Проведен сравнительный анализ результатов лечения и послеоперационных осложнений. Итогом работы стало определение показаний и особенностей применения высокоэнергетического лазерного излучения для проведения холедохолитотрипсии.
ПАТОФИЗИОЛОГИЧЕСКИЙ АСПЕКТ И ПСИХОФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ ФОРМИРОВАНИЯ РАССТРОЙСТВ АДАПТАЦИИ У СТУДЕНЧЕСКОЙ МОЛОДЕЖИ
Authors: Игнатенко Г. А. , Киосев Н. В.
Published: February 2021

Цель – охарактеризовать патофизиологический аспект и установить роль психофункциональных особенностей в формировании расстройств адаптации у студенческой молодежи.Материал и методы. Проведен анализ психоэмоционального состояния 208 студентов университета, определен уровень сформированности жизнестойкости. Методы исследования: информационно-аналитический, социально-демографический, клини­ко-анамнестический, клинико-психопато­логи­ческий, кли­нико-психологический, психодиагностический, ма­те­матико-статистический.Результаты и обсуждение. Установлен высокий уровень разнообразия психоэмоциональной сферы и жизнестойкости у студенческой молодежи. Показатели теста жизнестойкости у 30,8% (64/208) студентов находятся ниже нормы, а у 14,4% (30/208) респондентов – значительно ниже нормы, что отображает континуум индивидуальных вариаций состояния психологической дезадаптации, степени адаптационных нарушений и выраженности сопутствующих психопатологических радикалов с широким спектром негативных эмоций: от «дискомфорта» до «паники», а так же когнитивных и поведенческих нарушений.Заключение. Психоэмоциональные нарушения в рамках дезадаптационных расстройств у студентов младших курсов имеют субклинический уровень проявления. Ведущее место при этом занимают донозологические формы дисфункции тревожно-депрессивного, фобического, эмоционально-ла­биль­ного, соматовегетативного регистров, выступая предикторами формирования клинической симптоматики расстройств адаптации.Слабо сформированная жизнестойкость является фактором дезадаптации. Развитая жизнестойкость выступает условием и признаком психического здоровья современного студента.
РЕЦИДИВЫ ТУБЕРКУЛЕЗА У ВИЧ-ИНФИЦИРОВАННЫХ БОЛЬНЫХ, НАЧАВШИХ АНТИРЕТРОВИРУСНУЮ ТЕРАПИЮ
Authors: Корж Е. В. , Подчос Н. А. , Стрига Л. В. , Извекова Т. С. , Малявко Н. А.
Published: February 2021

Цель исследования – уточнить факторы, способствующие развитию рецидивов туберкулеза у ВИЧ-инфицированных больных, начавших АРТ. Материалы и методы. Проведен анализ результатов обследования 107 больных ко-инфекцией ТБ/ВИЧ, выписанных из Республиканской клинической туберкулезной больницы г. Донецка в 2010-2018 гг. Все пациенты начинали АРТ на госпитальном этапе лечения, в дальнейшем завершили основной курс противотуберкулезной химиотерапии и были переведены в диспансерную категорию 5.1. под наблюдение фтизиатра и инфекциониста. Период наблюдения составил более восьми лет – с января 2011 года по май 2019. Результаты и обсуждение. На момент поступления в отделение у 80 (74,8%) больных содержание CD4-лимфоцитов не превышало 200 кл/мкл, что у 33,6% обусловливало развитие генерализованного ТБ. Медиана доз ПТП перед началом АРТ составила 38. Развитие СВИС диагностировали у 23 (21,5%) человек, АРТ и антимикобактериальную терапию не прерывали. На май 2019 г. РТБ возникли у 19 (17,8%) больных, из них у девяти – в течение первого года после перевода в категорию 5.1. Прервали АРТ 15 человек, на момент развития рецидива медиана содержания CD4 в общей когорте составляла 127 кл/мкл – 9,7%. У 11 больных РТБ определялась мультирезистентность, тогда как при проведении предшествующего курса химиотерапии МРТБ был диагностирован у 3 лиц и у 8 больных не была выделена культура МБТ. При сравнении показателей больных РТБ с данными обследования 21 пациента без рецидива не выявлено достоверных различий по количеству больных, лечившихся ранее препаратами 1-го ряда (р=0,850), частоте отрицательных результатов культурального исследовании мокроты (р=0,374) и выявления МРТБ (р=0,905) в период нахождения в стационаре. На амбулаторном этапе лечения и наблюдения больные РТБ чаще прерывали АРТ (р<0,001), процентное содержание CD4 у них было ниже (р=0,009), чем у лиц без рецидивов.Выводы. Среди больных ко-инфекцией ТБ/ВИЧ, начавших АРТ, рецидивы туберкулеза были зарегистрированы у 19 (17,8%) лиц, из них у 9 – в течение первого года после перевода в диспансерную категорию 5,1. Фактором, способствующим развитию РТБ, можно считать наличие устойчивости МБТ, в том числе ее недовыявление при проведении предыдущего курса лечения. Регулярный прием АРТ способствовал предотвращению РТБ: больные без рецидивов реже прерывали АРТ (р<0,001), процентное содержание CD4 у них было выше (р=0,009), чем у больных с рецидивами. Из 19 больных РТБ были эффективно пролечены 11 человек, восемь больных умерли, из них у семи основной причиной смерти был МРТБ.
ВОЗМОЖНОСТИ МАНУАЛЬНОЙ ТЕРАПИИ В КОРРЕКЦИИ СКОЛИОЗА У ДЕТЕЙ СО СПИНАЛЬНЫМИ МЫШЕЧНЫМИ АТРОФИЯМИ
Authors: Шаймурзин М. Р. , Луцкий И. С. , Евтушенко О. С. , Ефименко М. В.
Published: February 2021

Актуальность. Продолжающийся поиск эффективной, безопасной терапии СМА диктует необходимость комбинаторного подхода в лечении данной патологии с определением семиотики двигательных нарушений, модификацией подходов нейрореабилитации, базирующихся на принципах ранней диагностики симптомов, влияющих на формирование осложнений и развитие тяжелой инвалидизации. Цель. Оценить возможности мануальной коррекции сколиотических деформаций позвоночника у детей СМА. Материал и методы. 54 ребенка со СМА 2 типа, включая 36 мальчиков (66,7%) и 18 девочек 29 (33,3%). Способ формирования выборки – систематический. Основная группа – 35 детей (64,8%), у которых применялась разработанная методика лечебной физкультуры с элементами strench-гимнастики. Группа сравнения – 19 детей (35,3%), проводилась ЛФК по общепринятой методике. Средний возраст пациентов – 5,6±0,4 года. Пациенты оценивались по шкалам L. McPeak и RHS с фиксацией результатов в установленные отметки заболевания: «исходные данные» и «3 года». Результаты. У детей из основной группы отмечено замедление прогрессирования двигательных нарушений и степени тяжести сколиотической деформации позвоночника: девиациия показателя «Бальная оценка функциональных возможностей по шкале RHS» основной группы в среднем на 2,2 (-11,6%) балла (р < 0,0001), снижение показателя «Бальная оценка функциональных возможностей по? шкале RHS» группы сравнения в среднем на 4,2 (в 3,4 раза) балла (р = 0,0010). Ни один пациент из основной группы не достиг 3 степени тяжести сколиоза, в то время как в группе сравнения у 19 (100%) детей состояние ухудшилось до 3 степени тяжестиВыводы. Предложенный комплекс проактивных реабилитационных мероприятий, направленный на коррекцию костно-суставных дефрмаций позвоночного столба, имеет важное значение с точки зрения перспективы модификации клинического течения заболевания и улучшения качества жизни.
СОВЕРШЕНСТВОВАНИЕ НАКОСТНОГО ОСТЕОСИНТЕЗА: ИСТОРИЧЕСКИЕ АСПЕКТЫ И ПЕРСПЕКТИВЫ РАЗВИТИЯ
Authors: Чернецкий В. Ю.
Published: February 2021

В статье представлена информация о совершенствовании внутреннего остеосинтеза с использованием накостных пластин. На основании изучения исторических аспектов систематизированы данные становления и развития метода накостного остеосинтеза. Описаны эволюционные этапы становления современных взглядов на использование накостных имплантатов от принципа открытой репозиции и внутренней фиксации до формирования концепции биологического остеосинтеза и применения минимально-инвазивного остеосинтеза. Проанализированы результаты научных исследований зарубежных авторов в контексте сравнения различных накостных пластин, что указывает на предпочтительное применение блокируемых компрессирующих пластин на современном этапе. Определены перспективные направления развития метода накостного остеосинтеза, совершенствования накостных пластин и методик их имплантации, среди которых отмечены накостные имплантаты из биодеградируемых материалов, что стало надежной и экономичной альтернативой металлическим фиксаторам. Знание исторических аспектов внутреннего остеосинтеза с использованием накостных пластин и развития данного направления может способствовать последующему совершенствованию накостного остеосинтеза с применением новых технологий.
MEDICAL DISCOVERIES, DISEASES AND SYNDROMES IN EPONYMOUS TERMINOLOGY (BASED ON ENGLISH, RUS-SIAN AND BULGARIAN MEDICAL DISCOURSE)
Authors: Танева С. Й.
Published: February 2021

Thirty medical eponymous terminological units named after great scientists, physicians, mythological and literary characters have been debated in the current study. The eponymous terms are presented in English, Russian and Bulgarian medical discourse. Brief medical descriptions of the particular discovery, disease or syndrome have been made. Information is given about the person after whom the eponymous term is named, as well. The basic parameters of scientific term are identified: a) Unambiguity; b) Accuracy; c) Brevity; d) Systematicity; e) Grammatical correctness; f) Stylistic neutrality; g) Word formation. Special attention is paid to the specifics of medical eponymous term, its encyclopedic informative volume and didactic aspect regarding the teaching process of specialized medical vocabulary at medical universities. Medical domain “invasion” is highlighted in a number of other domains: politics, computer technology, economics, automotive engineering, ecology, etc. (based on specific examples).
КЛИНИЧЕСКИЙ АНАЛИЗ ЛЕЧЕНИЯ БОЛЬНЫХ С ПОСТТРАВМАТИЧЕСКИМИ ХРОНИЧЕСКИМИ СУБДУРАЛЬНЫМИ ГЕМАТОМАМИ
Authors: Коровка С. Я. , Кардаш А. М. , Кардаш В. П.
Published: February 2021

Актульность работ, посвященных изучению клинических особенностей посттравматических хронических субдуральных гематом (ХСГ), определяется сохраняющимся высоким уровнем ивалидизации и смертности среди лиц трудоспособного возраста.Проведен анализ результатов диагностики и лечения 246 пациентов с посттравматическими ХСГ по данным нейрохирургической клиники Донецкого клинического территориального медицинского объединения за 2015-2020 гг. Представлены данные об особенностях клинического течения и методах консервативного и хирургического лечения ХСГ с применением миниинвазивных оперативных технологий. Значительная вариабельность причин, ведущих к возникновению рецидивов ХСГ и сроков их формирования в послеоперационном периоде, требует проведения адекватного клинико-патогенетического анализа с целью разработки системы профилактических мероприятий и обоснованного выбора эффективных методов диагностики и лечения рецидивирования ХСГ.
Evaluation of the clinical efficacy of local antibacterial therapy in the treatment of acute bacterial rhinosinusitis
Authors: Banashek-Meshcheriakova T. V. , Semyonov F. V.
Published: February 2021

Aim.To evaluate the clinical efficacy of Polydexa with phenylephrinum in the complex treatment of moderate acute bacterial rhinosinusitis.
Materials and methods.The article presents the results of a clinical study of 100 patients with moderate acute bacterial rhinosinusitis 37 (37%) men, 63 (63%) women aged 15 to 53 years. The patients were randomized into 2 groups of 50 people each. In the study group, patients received systemic antibiotic therapy and a topical nasal spray of Polydexa with phenylephrinum. The control group received systemic antibacterial therapy and long-acting local decongestants. The evaluation criteria were statistically significant differences in clinical and laboratory parameters of the control and main groups.
Results and conclusion.The pronounced anti-inflammatory, antimicrobial effects of the drug were confirmed; conclusions were drawn about the clinical efficacy, tolerability, safety of Polydexa with phenylephrinum and allows to achieve complete resolution of the pathological process in more cases.
Chronic intestinal pseudo-obstruction
Authors: Parfenov A. I. , Krums L. M. , Bykova S. V. , Ahmadullina O. V.
Published: February 2021

Chronic intestinal pseudo-obstruction a rare violation of the motor skills of the gastrointestinal complex, similar to mechanical obstruction, but without a mechanical obstacle. The development of chronic intestinal pseudo-obstruction is caused by a disturbance on the part of the smooth muscles and the nervous system of the gastrointestinal system. Common symptoms include constipation, abdominal pain, nausea, vomiting, bloating. Violation of peristalsis leads to food stagnation in the hinges of the small intestine, their dilation, the development of bacterial insemination syndrome. Eating disorders, bacterial contamination syndrome (CDDs) lead to impaired suction syndrome, cahexia. Treatment is aimed at providing adequate nutrition, the use of drugs that activate motor skills, suppress the growth of microbes in the small intestine, the implementation of intestinal decompression. Surgical treatment: resection of the affected segment of the gut. In the refractory course of the disease intestinal transplantation.
The prevalence of sarcopenia in patients with chronic pancreatitis: a meta-analysis
Authors: Maev I. V. , Andreev D. N. , Kucheryavyy Yu. A. , Levchenko A. I.
Published: February 2021

Aim.Systematization of data on the prevalence of sarcopenia in patients with chronic pancreatitis (CP).
Materials and methods.MEDLINE/PubMed, EMBASE, Cochrane, the Russian Science Citation Index (RSCI) through June 2020 were searched to identify studies evaluating the prevalence of sarcopenia in CP. Additionally, a search for relevant abstracts was carried out in the electronic databases of the conferences of the European Pancreatic Club (EPC), the International Association of Pancreatology (IAP) and the European Congress of Radiology (ECR). For the final analysis, publications were selected that used validated muscle mass assessment tests with detailed descriptive statistics to enable the resulting data to be included in the meta-analysis.
Results.The final analysis included 7 studies involving 604 patients with CP. The pooled prevalence of sarcopenia in patients with CP was 42.09% (95% confidence interval CI 27.84557.055). There was significant heterogeneity between the results (p0.0001; I2=90.81%). When studies with a total sample of less than 50 patients were excluded from the meta-analysis, the overall prevalence of sarcopenia in patients with CP was 22.24% (95% CI 15.47529.847).
Conclusion.The present meta-analysis demonstrated that sarcopenia is a common complication of CP and is observed in about 2 out of 5 patients with this inflammatory disease of the pancreas. Given the high incidence of adverse outcomes associated with sarcopenia, it is necessary to promptly diagnose this pathological condition in patients with CP.
Comparative capabilities of the speckle-tracking echocardiography technologiesin two-dimensional and three-dimensional modes in the detection of subclinical cardiotoxicity in patients with breast cancer
Authors: Saidova M. A. , Avalyan A. A. , Oshchepkova E. V. , Shitov V. N. , Chazova I. E.
Published: February 2021

Aim.The study was to assess the deformation properties of the left ventricle (LV) myocardium in patients with breast cancer initially and after anthracycline chemotherapy according to 2D and 3D speckle-tracking echocardiography (STE). Material and methods.the study included 99 patients with triple negative breast cancer with hypertensionandnormotension. All patients underwent standard transthoracic echocardiography with assessment of systolic function of the LV. To assess the indicator of global longitudinal strain (GLS), as a marker of cardiotoxicity, STE was used in two-and three-dimensional modes. In the three-dimensional STE mode, a new strain parameter, the global area strain (GAS) was evaluated. Results.The study showed that in patients with breast cancer for a more accurate assessment of LV systolic function (ejection fraction) it is advisable to use 3D-echocardiography. A comparative analysis revealed statistically significantly lower values of the GLS according to the three-dimensional mode of STE compared to two-dimensional. The study also evaluated a new strain parameter GAS (%). In patients with breast cancer during ROC analysis with a value of -14.0, the GAS indicator for the development of subclinical cardiotoxicity showed a sensitivity of 81.5% and a specificity of 73.3%. Сonclusion.the advantage of the STE in the three-dimensional mode, in contrast to the two-dimensional mode, is the simultaneous and more accurate assessment of LVEF. The value of the additional parameter of LV deformation the area of deformation requires further study.
Testing and validation of the Russian version of quality of life questionnaire in patients with GERD – GERD-HRQL
Authors: Ionova T. I. , Zinkovskaya A. V. , Mayevskaya E. A. , Nikitina T. P. , Porfirieva N. M. , Cheremushkina N. V. , Shaburov R. I. , Kucheryavyy Yu. A. , Maev I. V.
Published: February 2021

Aim.This study aimed to test the Russian version of GERD-HRQL in the focus group of patients with GERD, as well as to evaluate its psychometric properties reliability, validity and sensitivity.
Materials and methods.The total of 57 patients with GERD (mean age 45.812.4 years, 72% women, 68% patients with not erosive reflux disease, 84% had esophageal manifestations of GERD) were enrolled into the study. All the patients filled out the Russian version of GERD-HRQL and generic quality of life questionnaire RAND SF-36 during the routine visit to the gastroenterologist. According to the results of testing of GERD-HRQL, it was clear and easy to complete for patients and reflected the main concerns specific for GERD patients. The most frequent and bothersome symptoms/problems which interfered with quality of life in GERD patients were heartburn (100% of patients) and bloating (84% of patients). During the validation procedure, the high reliability and validity of the Russian version of GERD-HRQL were demonstrated. It was shown that the tool was sensitive both to changes over time and to clinically determined differences in patients status.
Results.The Total GERD-HRQL Score was significantly higher (worse quality of life) in the following groups: a) patients who had esophageal manifestations of GERB vs those without esophageal manifestations of GERB; b) patients with GERD complications vs those without GERD complications, c) patients with comorbidities of upper gastrointestinal tract vs without those comorbidities; d) patients with erosive esophagitis vs with non-erosive reflux disease (p0.05).
Conclusion.The developed Russian version of the GERD-HRQL questionnaire proved to have high psychometric properties and may be used in the Russian population of GERD patients both in research studies and in a real clinical practice.
Detection of kidney dysfunction potential biomarkers with hypertension in the persons of 25–45 years
Authors: Kovalkova N. A. , Khudyakova A. D. , Kashtanova E. V. , Polonskaya Ya. V. , Shcherbakova L. V. , Ragino Yu. I.
Published: February 2021

Aim.To assess the significance of symmetrical dimethylarginine (SDMA), uromodulin, retinol-binding protein 4 (RSB-4), transforming growth factorb1 (TGF-b1), plasminogen activator inhibitor 1 (PAI-1) as kidney dysfunction potential biomarkers persons with hypertension in persons 2545 years old.
Materials and methods.The study included 147 people. Hypertension was recorded with blood pressure (BP)140/90 mm Hg, renal dysfunction with GFRCKD-EPI90 ml/min/1.73 cm2. Four groups were formed: 1 individuals with hypertension and GFR90 ml/min/1.73 cm2; 2 with hypertension and GFR90 ml/min/1.73 cm2; 3 with BP140/90 mm Hg and GFR90 ml/min/1.73 cm2; 4 with BP140/90 mm Hg and GFR90 ml/min/1.73 cm2. The groups were comparable by gender, age, and number of respondents. Creatinine, SDMA, uromodulin, RSB-4, TGF-b1, PAI-1 levels were examined in all individuals in the serum.
Results.The maximum values of SDMA were determined in the 1st and 3rd groups (1.30 and 1.36 mol/l). In the 1st group, an association was found between SDMA and GFR (r=-0.324;p=0.048). In the 1st group, the minimum values of uromodulin were recorded, in the 4th group the maximum values (164.86 and 188.90 ng/ml; at the same timeр=0.921). The level of RSB-4 was the highest in the 1st group, the lowest in the 4th group (88.64 and 80.05 g/ml;p=0.011). The association of RSB-4 with SDMA in the 3rd group (r=0.400;p=0.017), the 4th group (r=0.403;p=0.018) was detected. The level of TGF-b1 was 1.5 times higher in the 1st group than in the 3rd (23.16 and 15.99 g/ml;p=0.026), the association of TGF-b1 with GFR in the 1st group had the opposite direction (r=-0.452;p=0.005). The study of similar indicators of PAI-1 did not reveal its relationship with renal dysfunction in hypertension.
Conclusion.The results of the study made it possible to consider SDMA, RSB-4, TGF-b1 as potential biomarkers of renal dysfunction in hypertension in persons 2545 years old.
Clinical and prognostic value of metabolic disorders in non-alcoholic fatty liver disease
Authors: Vakhrushev Ya. M. , Suchkova E. V. , Lukashevich А. Р.
Published: February 2021

Aim.A comprehensive assessment of metabolic parameters in patients with non-alcoholic fatty liver disease and based on them the development of prognostic criteria for the development of liver fibrosis.
Materials and methods.288 patients with non-alcoholic fatty liver disease at the stage of steatosis were examined. The patients underwent ultrasound examination of the hepatobiliary system using the SONIX OP apparatus (Canada), the FibroMax test, and liver elastography using the AIXPLORER apparatus (France). The parameters of anthropometry, lipid spectrum, protein and pigment metabolism, cytolysis, cholestasis, bilirubin, insulin in the blood serum were evaluated. The methods of statistical forecasting are used.
Results.The clinical picture in patients with non-alcoholic fatty liver disease at the stage of steatosis was nonspecific and was due to the presence of concomitant diseases of the digestive system and the cardiovascular system. A kettle index of up to 30 was observed in 26.5% of patients, from 30 to 34.9 in 37.5%, from 35 to 39.9 in 29.7% of patients, more than 40 in 6.3% of patients. The results obtained during the biochemical analysis of blood serum indicate the presence of atherogenic dyslipidemia, an increase in the level of total protein, bilirubin, transaminases, gamma-glutamyl transpeptidase and a decrease in alkaline phosphatase in relation to the control group. Against the background of elevated glucose levels, an increase in basal insulin levels was observed (p=0.001). HOMA-IR insulin resistance was increased in patients (p=0.01). When analyzing the results of the study, the main prognostic criteria (body mass index and atherogenicity coefficient) in the diagnosis of non-alcoholic fatty liver disease in the stage of steatosis with high specificity (97.8%) and sensitivity (96.2%) were determined. In determining the risk of progression of non-alcoholic fatty liver disease into liver fibrosis, the model of prognostic criteria included insulin and triglycerides with a specificity of 93.8% and a sensitivity of 85.7%.
Conclusion.Among many variable factors, we have identified the main prognostic criteria that are highly likely to diagnose non-alcoholic fatty liver disease at an early stage and determine the risk of progression to liver fibrosis.
Diagnosis and treatment of hereditary angioedema with normal C1-inhibitor level
Authors: Emelyanov A. V. , Leshenkova E. V. , Kameneva G. A.
Published: February 2021

Hereditary angioedema (HAE) with normal C1-inhibitor level is a rare potentially life-threatening disorder with autosomal dominant inheritance which was first described in 2000. Its clinical presentation is similar to HAE with C1-deficiency. The review is summarized data about its prevalence, mechanisms, genetics and diagnostic criteria. Different subtypes and treatment options (on demand, short term and long-term prophylaxis) are discussed. We describe family clinical cases of 2 female patients with normal C1-inhibitor and plasminogen gene mutation. Their features were late diagnosis (in 10 and 25 years after the onset of symptoms), family history (similar genetic mutation in 3 female members of the same family, including 1-asymtomatic) and combination of face, tongue, larynx and abdominal angioedema in patient and her sibling.
Anemia as a risk factor of contrast-associated acute kidney injury
Authors: Mironova O. Iu. , Deev A. D. , Lakotka P. G. , Fomin V. V.
Published: February 2021

Aim.The aim of our study was to assess the role of anemia as a risk factor of contrast-associated acute kidney injury (CA-AKI) in patients with stable coronary artery disease.
Materials and methods.1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). 83 patients had anemia. CA-AKI was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The primary endpoint of the study was the development of CA-AKI according to KDIGO criteria.
Results.CA-AKI developed in 12 (14.5%) patients with anemia according to the relative increase of the level of serum creatinine (25% and more from the baseline). With using the absolute increase of the level of serum creatinine the prevalence of CA-AKI was 2 (2.4%) patients. Patients with anemia had higher rate of CA-AKI than the overall population of the study (14.4% versus 12.7%). Although our results were not statistically significant (р=0.61, odds ratio 1.19, 95% confidence interval 0.632.24).
Conclusion.The prevalence of CA-AKI was higher in the group of patients with anemia, but didnt meet statistical significance and needs further evaluation in larger studies.
Rebamipide: evidence base for use in gastroenterology
Authors: Andreev D. N. , Maev I. V.
Published: February 2021

Rebamipide is a cytoprotective drug that has been used in practical gastroenterology for 30 years. This article summarizes the main results of the most relevant clinical studies of rebamipide in diseases of various parts of the gastrointestinal tract, including the esophagus, stomach, small and large intestine.
Recommendations for the Protocol of functional examination of the anorectal zone and disorders classification: the International Anorectal Physiology Working Group consensus and Russian real-world practice
Authors: Fomenko O. Yu. , Morozov S. V. , Scott S. Mark , Knowles H. Charles , Morozov D. A. , Shelygin Yu. A. , Maev I. V. , Nikityuk D. B. , Shkoda A. S. , Kashnikov V. N. , Bordin D. S. , Isakov V. A. , Biryukov O. M. , Belousova S. V. , Pimenova E. S. , Rumiantsev A. S. , Fedorov E. D. , Gvozdev M. Yu. , Trukhmanov A. S. , Storonova O. A. , Indeykina L. H. , Biryukova M. G. , Andreev D. N. , Kucheryavyy Yu. A. , Achkasov S. I.
Published: February 2021

This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for the performance, terminology used, and interpretation of anorectal function testing including anorectal manometry (focused on high-resolution manometry), the rectal sensory test, and the balloon expulsion test. Based on these measurements, a classification system for disorders of anorectal function is proposed. Aim to provide information about methods of diagnosis and new classification of functional anorectal disorders to a wide range of specialists general practitioners, therapists, gastroenterologists, coloproctologists all who face the manifestations of these diseases in everyday practice and determine the diagnostic and therapeutic algorithm. Current paper provides agreed statements of IAPWG Consensus and comments (in italics) of Russian experts on real-world practice, mainly on methodology of examination. These comments in no way intended to detract from the provisions agreed by the international group of experts. We hope that these comments will help to improve the quality of examination based on the systematization of local experience with the use of the methods discussed and the results obtained. Key recommendations: the International Anorectal Physiology Working Group protocol for the performance of anorectal function testing recommends a standardized sequence of maneuvers to test rectoanal reflexes, anal tone and contractility, rectoanal coordination, and rectal sensation. Major findings not seen in healthy controls defined by the classification are as follows: rectoanal areflexia, anal hypotension and hypocontractility, rectal hyposensitivity, and hypersensitivity. Minor and inconclusive findings that can be present in health and require additional information prior to diagnosis include anal hypertension and dyssynergia.
Effect of physicochemical properties on the pharmacokinetic parameters of the new representative of benzothiazinones antituberculosis drug macozinonе
Authors: Khokhlov A. L. , Mariandyshev A. O. , Shcherbakova V. S. , Ozerova I. V. , Kazaishvili Yu. G. , Igumnova O. V. , Bolgarina A. A. , Rudoy B. A.
Published: February 2021

Introduction.Tuberculosis (TB) is one of the top ten causes of death worldwide. Improvement of the treatment options via development of new drugs and treatment regimens that would be more convenient for patients is one of key options of improving the effecacy of the TB prevention and careis. Since the creation of new treatment regimens by minimizing the number of the drugs used and reducing the duration of treatment is the most promising and correct direction, macozinone, a new candidate of the benzothiazinone series, can become the basis for development of new chemotherapy regimens for drug-resistant forms of TB including the combination of macozinone with the most effective modern anti-TB drugs.
Aim.Comparative evaluation of the pharmacokinetic properties of macozinone capsules 80 mg and the new dosage form a dispersible tablet for preparation of oral solution.
Materials and methods.Solubility of the substance macozinone in biorelevant media in vitro, permeability of macozinone in the test Caco-2 in vitro, as well as pharmacokinetics of macozinone in dogs in vivo were evaluated.
Results.The solubility assessment in biorelevant media showed that the average limit of macozinone substance dissolution in the pH 5.0 acetate buffer solution was from 6 to 9 mg/l, in FaSSIF medium (fasted) from 2.5 to 4 mg/l, and in FeSSIF medium (after meals) from 16.8 to 29 mg/l.
It is established that the cell permeability of the pharmaceutical substance macozinone in the CACO-2 test system is on average 2.510-6cm/s in the forward direction from the apical to basolateral cell membrane, and 1.510-6cm/s in the reverse direction, which corresponds to low permeability. The main pharmacokinetic parameters of macozinone dispersable tablets 160 mg, after dosing with food and on an empty stomach, as well as capsules 80 mg, when administered on an empty stomach in vivo studies in dogs are presented.
Discussion.The specific physicochemical properties of macozinone, the problems of developing the new dosage form, as well as ways of solving some of them are presented.
Conclusion.In the process of new dosage forms development, the existing chemical properties of the macozinone substance should be considered. One of the promising ways of increasing bioavailability and, consiquently, efficacy is development a fundamentally new drug form with modified release within the absorption window.
PAP-therapy adherence in patients with obstructive sleep apnea and cardiovascular diseases
Authors: Mikhailova Oksana O. , Elfimova Eugenia M. , Litvin Aleksander Yu. , Chazova Irina E.
Published: February 2021

Materials and methods. The study included 119 patients with obstructive sleep apnea (OSA) and cardiovascular diseases (CVD) who were followed up at the National Medical Research Center of Cardiology of the Ministry of Health of the Russian Federation in the period from 2012 to 2020, and have been receiving positive airway pressure (PAP) therapy (93 men, 78.2%). The median follow-up was 3.0 years [1.5; 5.0]. The adherence criteria were the following: the usage of the PAP device for at least 71% of nights a year, and at least 4 hours per night.
Results. 64.3% of patients met the criteria for adherence to PAP therapy (use more than 4 hours/night, more than 71% of nights). The adherent patients were older (64.0 years [58.5; 68.0] versus 59.0 years [53.0; 65.0] resp., p=0.03) and had a higher apnea-hypopnea index AHI (47.7 events/h [37.5; 64.4] versus 38.2 events/h [30.4; 52.7] resp., p=0.04).
Patients with stage III of hypertension were using a PAP device every night significantly less (3.4 h/night [1.1; 3.6] versus 6.3 h/night [5.3; 7.4] respectively, p=0.00) in comparison with patients with hypertension stages III. The adherence of patients with or without coronary artery disease (CAD) and paroxysmal atrial fibrillation (AF) did not differ. There was no significant difference in the incidence of stage III hypertension, CAD, and permanent AF between the groups of adherent and non-adherent to PAP therapy patients.
Conclusion. 63.4% of patients with CVD were adherent to PAP therapy. Adherent patients were older and had a higher AHI. Patients with stage III hypertension were worse adherent to PAP therapy in comparison with patients with hypertension of lesser stages. The CVDs course in adherent and non-adherent patients did not differ.
Obesity as a risk factor of contrast-induced acute kidney injury in patients with arterial hypertension and stable coronary artery disease
Authors: Mironova Olga Iu. , Sivakova Olga A. , Fomin Viktor V.
Published: February 2021

Background. The prevalence of obesity in patients with stable coronary artery disease (CAD) and arterial hypertension (AH) is increasing each year. As the number of percutaneous coronary interventions requiring contrast media administration is rising in this group of patients, the risk of contrast-induced acute kidney injury (CI-AKI) remains high. The most important risk factors of CI-AKI in this group of patients remain to be determined as well as their prognostic significance.
Aim. The aim of the study was to assess the role of obesity as a risk factor of CI-AKI in patients with stable CAD and AH.
Materials and methods. 863 patients with stable CAD and AH were included in the prospective open observational cohort study (ClinicalTrials.gov ID NCT04014153). 398 patients were obese and 465 had body mass index (BMI) below 30 kg/m2. CI-AKI was defined as the 25% rise (or 0.5 mg/dl) of serum creatinine from baseline assessed 48 hours after administration of contrast media. The primary endpoint was the development of CI-AKI.
Results. The rate of CI-AKI in patients with obesity was 12.6%, without obesity 12.7%, but the difference between groups was not statistically significant (p=0.935, 95% CI -0.0430.046). The rate of CI-AKI in male patients with obesity was higher than in female ones. The logistic regression model of CI-AKI development in patients with stable CAD, AH and obesity was build (AUC 0.9928, р0,0001, 95% CI 0.98191) and included age, weight, body mass index, female gender, heart failure, diabetes mellitus, proteinuria, anemia, baseline creatinine, contrast volume and the difference between baseline serum creatinine and creatinine level after the contrast media exposure. The baseline level of creatinine and the difference between the levels of creatinine before and after contrast media administration were statistically significant risk factors in the model.
Conclusion. The rate of CI-AKI in patients with stable CAD, AH and obesity was 12.6%. The main risk factors of CI-AKI development in multiple logistic regression model were the baseline level of creatinine and the difference between levels of serum creatinine before and after contrast media administration.
Drying kinetics and thin layer modeling of ogi produced from six maize varieties at varying soaking period and drying temperature
Authors: Bolaji O.T. , Adepoju P.A. , Adelana E.O. , Adesina B.S.
Published: February 2021

The drying kinetics of ogi produced from six varieties of maize at varying soaking period
(12, 24 and 36 hrs) and drying temperature of 40, 50 and 60oC, respectively were studied.
Seven common thin layer models were evaluated, and the best models were selected. The
moisture content of ogi decreased with increased drying temperature and drying time
while the drying rate increased with an increase in drying temperature and decreased with
an increase in drying time. Logarithmic and two term models best fitted about 40.77% (22
samples each). However, where two term models were selected best, the R2 values ranged
from 0.9858-0.99999999, χ
2 = 0.03715-0.000412, RMSE = 0.02206-0.0000677, unlike
Logarithmic model that ranged from 0.8876-0.9964, χ
2 = 0.07045-0.001447, RMSE =
0.1084-0.01098. There was no definite pattern for effective moisture diffusivity (Deff) and
Activation energy (Ea). This research work strongly suggests that the drying process was
predominantly in the falling rate period (FRP) and was significantly affected by the
change in temperature and moisture gradient. The activation energy obtained for ogi at
varying soaking period and drying temperature ranged from 2.58-12.00 kJ/mol (A4Y),
7.72-44.95 kJ/mol (A4W), 14.53-35.88 kJ/mol (S7Y), 6.02-20.10 kJ/mol (D2Y), 14.024-
45.31 kJ/mol (DIY) and 19.34-64.22 kJ/mol (T3W). It was obviously indicated in this
research that the soaking period had less or no impact on the drying behavior of ogi
compared with the influence of drying temperature, drying time and initial moisture
content.
Antioxidant activities and simultaneous HPLC-DAD profiling of polyphenolic compounds from Moringa oleifera Lam. Leaves grown in Bangladesh
Authors: Ahmed K.S. , Jahan I.A. , Jahan F. , Hosain H.
Published: February 2021

Moringa oleifera Lam. has been used as a traditional medicine for the treatment of several
diseases. In this study, the antioxidant activity and simultaneous HPLC profiling of
polyphenolic compounds in 80% ethanol and water extracts of M. oleifera tender and
mature leaves available in Bangladesh were investigated. The 80% ethanol extract of M.
oleifera tender leaves contained high concentration and more amount of 3,4-
dihydroxybenzoic acid, (-) epicatechin and rosmarinic acid (201.32±1.94, 213.08±1.96
and 133.84±1.42 mg/100 g of dry extract, respectively) than that of mature leaves
(82.55±1.09, 141.86±1.10 and 16.23±0.76 mg/100 g of dry extract, respectively). On the
other hand, the water extract of M. oleifera tender leaves contained a high concentration of
catechin hydrate, trans-ferulic acid and quercetin (530.05±1.91, 166.38±0.90 and
771.74±1.34 mg/100 g of dry extract, respectively) than that of mature leaves
(207.21±0.90, 62.42±0.45 and 483.25±1.04 mg/100 g of dry extract, respectively). It was
also found that 3,4-dihydroxybenzoic acid, catechol, p-coumaric acid and trans-cinnamic
acid were detected only in 80% ethanol extract of M. oleifera leaves but syringic acid was
identified in the water extract. In DPPH free radical scavenging activity test, IC50 values
of 80% ethanol extract of tender leaves (EETL), 80% ethanol extract of mature leaves
(EEML), water extract of tender leaves (WETL) and water extract of mature leaves
(WEML) were found to be moderately significant (105.50±1.05, 115.00±1.14,
216.00±1.34 and 269.50±1.56 μg/mL, respectively) when compared to the IC50 value of
ascorbic acid, 3.32±0.07 μg/mL. The polyphenolic compounds are responsible for
antioxidant activity. On the basis of the present study, it can be suggested that the leaves
show antioxidant activity and it’s contained a significant amount and different types of
polyphenolic compounds. Standardized polyphenolic compounds from M. oleifera leaves
could be used as a better source of natural antioxidant supplement.
Resistant starch, amylose, and amylopectin content in breadfruit cookies as an alternative snack for individuals with diabetes mellitus
Authors: Fitriani Z.A. , Dieny F.F. , Margawati A. , Jauharany F.F.
Published: February 2021

Uncontrolled hyperglycaemia in individuals with diabetes mellitus can increase the risk
factors for disease complications. Therefore, lifestyle management becomes a vital
measure for those individuals, especially in diet management, to control their blood sugar
level. Breadfruit starch-based cookies contain resistant starch, amylose, and amylopectin
that can inhibit the increment of blood sugar levels. Hence, these cookies can be used as
an alternative snack for those individuals. This study was aimed to analyse the content of
resistant starch, amylose, and amylopectin, as well as the acceptability level of breadfruit
starch-based cookies. We used a completely randomised experiment using four
formulations with various breadfruit flour content: 25%, 50%, 75% and 100%. The
breadfruit formulation containing breadfruit flour (BF) and wheat flour (WF). Formula
25% (25% BF 75% WF, 50% (50% BF and WF), 75% (75% BF 25% WF), and 100% BF.
The one-way ANOVA was used to compare the content of resistant starch, amylose, and
amylopectin among the cookies. Furthermore, the Friedman test was used to analyse the
acceptance level of the cookies, which includes colour, odour, texture, and flavour. The
cookies contain 19.38-20.51% of resistant starch, 13.55-16.60% of amylose, and 83.39-
86.44% of amylopectin. The highest resistant starch and amylose contents were found in
cookies with 100% breadfruit flour content, while the highest amylopectin content was
found in the 25% formulation. The acceptability level of the cookies included colour,
odour, texture, and flavour. Cookies made with 100% breadfruit flour contained the
highest resistant starch and amylose, but the lowest amylopectin. It also received the
highest acceptability among the panellists.