bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S16 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

CD8 intra-tumoral infiltration percentage by IHC
Supplementary Table S3 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: July 2024

Table S3. Efficacy summary per BICR with adagrasib plus cetuximab in previously treated patients with KRASG12C-mutated unresectable or metastatic CRC, overall, and in phase 1 and phase 2 cohorts.
Supplementary Figures S1-S12 from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Authors: Ryan Meagan B. , Quade Bradley , Schenk Natasha , Fang Zhong , Zingg Marshall , Cohen Steven E. , Swalm Brooke M. , Li Chun , Özen Ayşegül , Ye Chaoyang , Ritorto Maria Stella , Huang Xin , Dar Arvin C. , Han Yongxin , Hoeflich Klaus P. , Hale Michael , Hagel Margit
Published: July 2024

Supplementary Figure S1 supports Figure 1 and contains cellular properties of NST-628 and a comparison with tramentib Supplementary Figure S2 supports Figure 2 and contains KSR1 data Supplementary Figure S3 supports Figure 2 and contains additional RAF-MEK crystal structures Supplementary Figure S4 supports Figure 2 and contains EGF stimulation experiment Supplementary Figure S5 supports Figure 2 and contains CRAF-MEK cryo-EM Supplementary Figure S6 supports Figure 3 and contains BRAF and MEK IPs, and CRAF IP/MS Supplementary Figure S7 supports Figure 4 and contains the full OMNI screen panel Supplementary Figure S8 supports Figure 4 and contains NST-628 RNAseq, signaling and proteomics studies Supplementary Figure S9 supports Figure 4 and contains NST-628 resistance studies Supplementary Figure S10 supports Figure 5 and contains HCT116 and IPC298 in vivo data Supplementary Figure S11 supports Figure 6 and contains NST-628 PK as well as SK-MEL-2 and MeWo in vivo data Supplementary Figure S12 Supports Figure 7 and contains KRAS G12C inhibitor combination studies
Figure 5 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

Notch4 is expressed on tumor ECs, and treatment alters the tumor vessel transcriptional profile. A, Representative flow plots of gating for CD31+ cells in Py8119 and B16F10 tumors. B, Histograms comparing E7011 and human IgG binding to CD31+ and CD31− cell populations from dissociated Py8119 and B16F10 tumors (n = 3). Left, E7011 samples were concatenated and merged into a single representative histogram. Right, Graph of concatenated MFI from Py8119 and B16F10 samples bound with E7011 or human IgG. C, Heatmaps of significantly upregulated and downregulated differentially expressed genes isolated from IP polysomes from tumor ECs treated with 6-3-A6 or control IgG (n = 3). Boxes indicate genes implicated in GPCR control of angiogenesis (red), endothelial nitric oxide regulation (blue), and inflammatory/immune response (green). D, Reactome pathway analysis of upregulated and downregulated pathways was performed using g:Profiler, and significance threshold by Benjamini–Hochberg FDR was set at 0.05. A, Fold cutoff of −log10(Padj) > 2 was used to select the displayed pathways. Statistical analysis performed with the t test for perfusion studies, plotted as average ± SEM; *, P < 0.05; **, P < 0.005. Heatmap data presented as Z-scores, which integrate both fold change and significance.
Efficacy and Safety of Phytotherapy and Anthroposophic Medicine in Seasonal Allergic Rhinitis: A Systematic Review
Authors: Braunwalder Céline , Ertl Jana , Wullschleger Matteo , Timm Eliane , Wolf Ursula
Published: July 2024

Introduction: Seasonal allergic rhinitis (SAR) is a common health condition that is associated with an increased risk for bronchial asthma. Besides conventional medicine, treatments from traditional, complementary and integrative medicine are widely used by individuals with SAR. This review aims to systematically summarize evidence on the efficacy, effectiveness, and safety of European/Western phytotherapy (PT) and medications from anthroposophic medicine (AM) in individuals with SAR. Methods: Four electronic databases were screened for clinical studies published between January 1990 and March 2023. The results were qualitatively synthesized and the study quality was assessed. Results: In total, 14 studies were included, 11 from European/Western PT and three from AM. About half of the studies were rated as being of sufficient quality. The most frequently studied plant was Petasites hybridus (butterbur), showing beneficial effects on immunological parameters, subjective symptoms, and nasal airflow. Beneficial immunological and clinical effects were also shown for an herbal preparation combining Citrus limonis (lemon) and Cydonia oblonga (quince). The medications examined by studies of sufficient quality were judged to be safe. Conclusion: In summary, this systematic review highlights two herbal preparations, one from European/Western PT and one from AM, that appear to be promising options in the treatment of SAR.
Negative Prognostic Associations of Selective Serotonin Reuptake Inhibitors Use in Hospitalized COVID-19 Patients and Potential Contribution of Cardiovascular Comorbidities
Authors: Papic Ivan , Bistrovic Petra , Krecak Ivan , Ortner Hadziabdic Maja , Lucijanic Marko
Published: July 2024

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative agent of coronavirus disease 2019 (COVID-19), a very contagious systemic disease dominantly affecting the respiratory tract. Recent findings oppose earlier suggestions that selective serotonin reuptake inhibitors (SSRIs) might be protective during acute SARS-CoV-2 infection, prompting the current study. Methods: The institutional registry of a tertiary referral center was retrospectively evaluated for SSRI use and associated clinical outcomes among hospitalized COVID-19 patients with mostly severe and critical disease. Results: Among 1,558 patients, there were 78 (5%) exposed to SSRI during hospitalization. SSRI users in comparison to non-users did not significantly differ in their demographic characteristics, comorbidity profile or the severity of COVID-19 symptoms and associated inflammatory response at admission. In multivariate analyses adjusted for clinically meaningful variables, SSRI use was significantly associated with higher risks of death, mechanical ventilation, intensive care unit treatment, and bacteremia, whereas no significant relationship with risks of venous, arterial thrombosis, and major bleeding was present. Patients with less severe initial COVID-19 presentation, lower inflammatory burden, higher platelet count, lower cumulative comorbidity burden, presence of hyperlipidemia, atrial fibrillation, chronic heart failure and nonexposed to acetylsalicylic-acid had higher mortality associated with SSRI use. Conclusions: Findings of the current study validate findings of higher mortality but also report higher tendency for respiratory deterioration, intensive care unit treatment, and bacteremia associated with SSRI use among hospitalized COVID-19 patients. These findings also suggest the potential contribution of cardiovascular comorbidities to detrimental clinical course of SSRI exposed patients.
Dual-Task Performance and Brain Morphologic Characteristics in Parkinson’s Disease
Authors: Carlson Sarah J. , Chiu Yi-Fang , Landers Merrill R. , Fritz Nora E. , Mishra Virendra R. , Longhurst Jason K.
Published: July 2024

Introduction: Parkinson’s disease (PD) reduces an individual’s capacity for automaticity which limits their ability to perform two tasks simultaneously, negatively impacting daily function. Understanding the neural correlates of dual tasks (DTs) may pave the way for targeted therapies. To better understand automaticity in PD, we aimed to explore whether individuals with differing DT performances possessed differences in brain morphologic characteristics. Methods: Data were obtained from 34 individuals with PD and 47 healthy older adults including (1) demographics (age, sex), (2) disease severity (Movement Disorder Society – Unified Parkinson’s Disease Rating Scale [MDS-UPDRS], Hoehn and Yahr, levodopa equivalent daily dose [LEDD]), (3) cognition (Montreal Cognitive Assessment), (4) LEDD, (5) single-task and DT performance during a DT-timed-up-and-go test utilizing a serial subtraction task, and (6) cortical thicknesses and subcortical volumes obtained from volumetric MRI. Participants were categorized as low or high DT performers if their combined DT effect was greater than the previously determined mean value for healthy older adults (μ = –74.2). Nonparametric testing using Quade’s ANCOVA was conducted to compare cortical thicknesses and brain volumes between the highDT and lowDT groups while controlling for covariates: age, sex, MDS-UPDRS part III, LEDD, and intracranial volume. Secondarily, similar comparisons were made between the healthy older adult group and the highDT and lowDT groups. Lastly, a hierarchical linear regression model was conducted regressing combined DT effect on covariates (block one) and cortical thicknesses (block 2) in stepwise fashion. Results: The highDT group had thicker cortices than the lowDT group in the right primary somatosensory cortex (p = 0.001), bilateral primary motor cortices (p ≤ 0.001, left; p = 0.002, right), bilateral supplementary motor areas (p = 0.001, left; p < 0.001, right), and mean of the bilateral hemispheres (p = 0.001, left; p < 0.001, right). Of note, left primary cortex thickness (p = 0.002), left prefrontal cortex thickness (p < 0.001), and right supplementary motor area thickness (p = 0.003) differed when adding a healthy comparison group. Additionally, the regression analysis found that the left paracentral lobule thickness explained 20.8% of the variability in combined DT effect (p = 0.011) beyond the influence of covariates. Conclusions: These results suggest regions underlying DT performance, specifically, a convergence of neural control relying on sensorimotor integration, motor planning, and motor activation to achieve higher levels of DT performance for individuals with PD.
Chronic Lymphocytic Leukemia in Pregnancy: A Review of the Available Literature and the Pharmacological Challenges in Management
Authors: Badr Ahmed , Benkhadra Maria , Elsayed Basel , Metwally Omar , Elhadary Mohamed , Elshoeibi Amgad Mohamed , Ghasoub Rola , Elshoeibi Raghad Mohamed , Alshemmari Salem , Mattar Mervat , Alfarsi Khalil , Yassin Mohamed
Published: July 2024

Background: Chronic lymphocytic leukemia (CLL) is a rare hematologic malignancy to occur in pregnancy, with an estimated incidence of 1 in 75,000 pregnancies. Pregnant women with CLL face increased susceptibility to infections, due to a weakened immune system. Higher risks of fetal malformations and death are associated with CLL treatment during pregnancy, emphasizing the need for careful consideration and management in these cases. Summary: This review aimed to summarize the current evidence regarding the diagnosis, prognosis, and treatment of CLL in pregnant cases. A comprehensive search strategy was employed across multiple databases, yielding 14 case reports for inclusion. The cases were divided based on CLL diagnosis onset, either before or during pregnancy. Our results showed that patients diagnosed during pregnancy (n = 5) were mostly asymptomatic at diagnosis, with management ranging from supportive care to leukapheresis and transfusions. Postpartum treatment varied, with some patients requiring no additional therapy and others receiving chemotherapy. Pregnancy outcomes were generally favorable, with most neonates born healthy at term. However, one case of Richter transformation resulted in maternal death despite treatment. Among patients with pre-existing CLL (n = 9), the majority experienced an indolent course during pregnancy, with only supportive care required. A few cases necessitated treatment due to progressive disease or complications, including chemotherapy, leukapheresis, and splenectomy. Key Messages: This review highlights the heterogeneous nature of CLL in pregnancy and the importance of individualized management based on disease severity, gestational age, and maternal-fetal risks. Close monitoring, supportive care, and a multidisciplinary approach are essential for optimizing outcomes in this rare and complex clinical scenario.
Development of robotic arm control using Arduino controller
Authors: Chenchireddy Kalagotla , Dora Radhika , Mulla Gouse Basha , Jegathesan Varghese , Sydu Shabbier Ahmed
Published: July 2024

The advance of Arduino-based technology has spurred innovation in the realm of robotic arm control, offering a cost-effective and accessible platform for enthusiasts and professionals alike. This paper presents the development of robot arm control using an Arduino controller. The work involves the integration of Arduino microcontrollers and sensors to enable precise and dynamic control of a robotic arm. The proposed robot is controlled by 4 servo motors, the motors rotate left, right, front, and back. The paper discusses the challenges encountered during the development process and proposes solutions, paving the way for further advancements in this burgeoning field. With Arduino's widespread availability and affordability, the presented robotic arm control system holds promise for expanding the accessibility of robotics education and fostering innovation in automation technologies. This paper provides a glimpse into the promising synergy between Arduino and robotic arm control, highlighting the contributions and implications of this technology in shaping the future of automation.
Vector synthesis of fault testing map for logic
Authors: Hahanov Vladimir , Gharibi Wajeb , Chumachenko Svetlana , Litvinova Eugenia
Published: July 2024

Vector synthesis of fault testing (simulation) map for logic is proposed, which without simulation allows to determine of all faults detected on test sets, as well as determining test sets to detect specified faults. For synthesis, a superposition of smart data structures is used, containing: a deductive matrix D, as a derivative of the logical vector L, test truth table T, and fault truth table F. The deductive matrix is seen as the gene of functionality and base of fault simulation mechanism to solve all the problems of testing and verification. In the matrix synthesis, an axiom is used: all the mentioned tables are identical in shape to each other and always interact with each other convolutionally T⊕L⊕F=0. A universal deductive reversing converter “test-faults” and “faults-test” for logical functionalities of any dimension is proposed. Converter functions: fault simulation on test sets T→F and synthesis of test sets F→T to detect the specified faults. The converter can be used as a test generation and fault simulation service for IP-core system-on-chip (SoC) under the IEEE 1500 SECT standard. Based on the deductive matrix, a fault testing map for logic is built, where each test set is matched with the logic-detected faults of the input lines.
An approach for modern gardening through monitoring and maintenance of plant health
Authors: Swami Siddharth , Singh Rajesh , Gehlot Anita , Sharma Sameer Dev , Kumar Dharmendra
Published: July 2024

The study explores the use of internet of things (IoT) devices in agriculture to improve sustainable practices and environmental concerns. It uses the ESP8266 microcontroller and the Blynk platform to create a revolutionary plant health monitoring and automated care system. The system is designed to handle continuous monitoring and plant maintenance in various environmental conditions. Sensors measuring light, temperature, humidity, and soil moisture are strategically placed to receive real-time data. The ESP8266 microcontroller analyzes this information and links it to the Blynk cloud for accessibility via mobile or web applications. The system is effective in monitoring ideal growing conditions, such as soil moisture and weather conditions. Automated care elements like irrigation and supplemental lighting have been shown to improve plant growth and health. The study contributes to smart farming by offering an affordable and easy way to automate and monitor plant health, demonstrating how IoT technologies can enhance agricultural practices, conserve resources, and enable remote management of plant ecosystems.
Seguros para os pobres: ironias da financeirização da pobreza na África do Sul
Authors: Fromm Deborah , Pinho Isabela Vianna , Gobbi Fernanda de
Published: July 2024

This text makes a Bibliographical Critique of the book "Ironies of Solidarity: Insurance and Financialization of Kinship in South Africa", written by the Dutch anthropologist Erik Bähre and published in 2020. The book brings an original reflection on the processes of financialisation of everyday life and poverty in the so-called Global South. The sensitive ethnography, conducted in Cape Town, shifts assumptions and brings a relevant contribution to social studies of the economy and the relations between moralities and markets. More than that, it brings relevant insights and methodological propositions for an approach to global financial capitalism based on the contradictions and ironies produced in people's daily lives. The book draws attention to how insurance, especially in its form marketed by large financial institutions, is a type of solidarity distinct from the forms usually studied by anthropologists. Anthropological theory has devoted itself more thoroughly to the study of community forms of solidarity and usually apprehends "the market" or "neoliberalism" as a force that corrupts the spheres of intimacy and personal ties. The book allows us to develop more sophisticated strategies for understanding such social processes from an anthropological approach.
Relationship of Ketosis With Myocardial Glucose Uptake Among Patients Undergoing FDG PET/CT for Evaluation of Cardiac Sarcoidosis
Authors: Vidula Mahesh K. , Selvaraj Senthil , Rojulpote Chaitanya , Bhattaru Abhijit , Kc Wumesh , Hansbury Mary , Schubert Erin , Clancy Caitlin B. , Rossman Milton , Goldberg Lee R. , Farwell Michael , Pryma Daniel , Bravo Paco E.
Published: July 2024

BACKGROUND:

Fluorine-18 fluorodeoxyglucose (FDG) with positron emission tomography (PET) is the standard for detecting myocardial inflammation in cardiac sarcoidosis, requiring preparation with the ketogenic diet (KD) to achieve myocardial glucose suppression. Despite this, incomplete myocardial glucose suppression remains a significant issue, and strategies to reduce myocardial glucose uptake (MGU) and identify incomplete myocardial glucose suppression are required. This study sought to understand the relationship between point-of-care beta-hydroxybutyrate (BHB) and different patterns of MGU and between KD and fasting duration with MGU in patients undergoing evaluation for cardiac sarcoidosis.

METHODS:

We prospectively included 471 outpatients who underwent FDG-PET for cardiac sarcoidosis evaluation, followed the KD for 1 (n=100), 2 (n=29), and ≥3 days (n=342), fasted for at least 12 hours, and had BHB levels measured immediately before FDG injection. Images were classified as (1) no MGU (negative), (2) focal/multifocal (positive), (3) diffuse (nondiagnostic), or (4) nonspecific uptake (NS-MGU).

RESULTS:

Cardiac FDG-PET scans were interpreted as the following: 376 (79.83%) negative; 61 (12.95%) positive; 14 (2.97%) diffuse; and 20 (4.25%) NS-MGU. There was a strong negative relationship between BHB levels and MGU (
P
<0.0001). BHB levels increased significantly with KD duration (
P
<0.0001) and fasting time (
P
=0.0067). The combined rate of diffuse, NS-MGU, and positive scans (34%, 28%, 16%) decreased inversely with KD duration (1, 2, and ≥3 days, respectively). However, MGU was not different across different fasting times (
P
=0.6). Blood glucose levels were not associated with MGU (
P
=0.17) and only weakly associated with BHB levels (R
2
=0.03;
P
<0.001).

CONCLUSIONS:

We observed a strong inverse relationship between ketosis and patterns of MGU. Longer KD and fasting durations are associated with higher ketosis. However, only KD duration was associated with lower rates of MGU. Measurement of BHB levels before FDG-PET using point-of-care testing is feasible and may facilitate the management of patients referred for myocardial inflammation.
Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA
2
Prostanoids/TP Axis
Authors: Ge Jiahui , Zhou Yingbi , Li Hui , Zeng Ruhui , Xie Kaiqi , Leng Jing , Chen Xijian , Yu Gang , Shi Xinya , Xu Yineng , He Dong , Guo Pi , Zhou Yongyin , Luo Hongjun , Luo Wenhong , Liu Bin
Published: July 2024

BACKGROUND:

Prostaglandin I
2
synthesized by endothelial COX (cyclooxygenase) evokes potent vasodilation in some blood vessels but is paradoxically responsible for endothelium-dependent constriction (EDC) in others. Prostaglandin I
2
production and EDC may be enhanced in diseases such as hypertension. However, how PGIS (prostaglandin I
2
synthase) deficiency affects EDC and how this is implicated in the consequent cardiovascular pathologies remain largely unknown.

METHODS:

Experiments were performed with wild-type,
Pgis
knockout (
Pgis

−
/
−

) and
Pgis
/thromboxane-prostanoid receptor gene (
Tp
) double knockout (
Pgis

−
/
−

Tp

−
/
−

) mice and
Pgis

−
/
−

mice transplanted with unfractionated wild-type or
Cox-1

−
/
−

bone marrow cells, as well as human umbilical arteries. COX-derived prostanoids were measured by high-performance liquid chromatography-mass spectrometry. Vasomotor responses of distinct types of arteries were assessed by isometric force measurement. Parameters of hypertension, vascular remodeling, and cardiac hypertrophy in mice at different ages were monitored.

RESULTS:

PGF
2α
, PGE
2
, and a trace amount of PGD
2
, but not thromboxane A
2
(TxA
2
), were produced in response to acetylcholine in
Pgis

−
/
−

or PGIS-inhibited arteries. PGIS deficiency resulted in exacerbation or occurrence of EDC ex vivo and in vivo. Endothelium-dependent hyperpolarization was unchanged, but phosphorylation levels of eNOS (endothelial nitric oxide synthase) at Ser1177 and Thr495 were altered and NO production and the NO-dependent relaxation evoked by acetylcholine were remarkably reduced in
Pgis

−
/
−

aortas.
Pgis

−
/
−

mice developed high blood pressure and vascular remodeling at 16 to 17 weeks and subsequently cardiac hypertrophy at 24 to 26 weeks. Meanwhile, blood pressure and cardiac parameters remained normal at 8 to 10 weeks. Additional ablation of TP (TxA
2
receptor) not only restrained EDC and the downregulation of NO signaling in
Pgis

−
/
−

mice but also ameliorated the cardiovascular abnormalities. Stimulation of
Pgis

−
/
−

vessels with acetylcholine in the presence of platelets led to increased TxA
2
generation. COX-1 disruption in bone marrow–derived cells failed to affect the development of high blood pressure and vascular remodeling in
Pgis

−
/
−

mice though it largely suppressed the increase of plasma TxB
2
(TxA
2
metabolite) level.

CONCLUSIONS:

Our study demonstrates that the non-TxA
2
prostanoids/TP axis plays an essential role in mediating the augmentation of EDC and cardiovascular disorders when PGIS is deficient, suggesting TP as a promising therapeutic target in diseases associated with PGIS insufficiency.
Association Between Caregiver Strain and Self‐Care Among Caregivers With Hypertension: Findings From the REGARDS Study
Authors: Gobourne Asia , Ringel Joanna Bryan , King Alexandra , Safford Monika , Riffin Catherine , Adelman Ronal , Bress Adam , Paul Tracy K. , Durant Raegan W. , Roth David L. , Sterling Madeline R.
Published: July 2024

Background

Self‐care for adults with hypertension includes adherence to lifestyle behaviors and medication. For unpaid caregivers with hypertension, the burden of family caregiving may adversely impact self‐care. We examined the association between caregiver strain and hypertension self‐care among caregivers with hypertension.

Methods and Results

We included participants of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study who identified as caregivers and had hypertension. Caregiver strain, assessed by self‐report, was categorized as “none/some” or “high.” Hypertension self‐care was assessed individually across 5 domains (Dietary Approaches to Stop Hypertension [DASH] diet, physical activity, alcohol use, cigarette smoking, and medication adherence) and a composite self‐care score summing performance across them. The association between caregiver strain and hypertension self‐care was examined with multivariable linear regression. Among the 2128 caregivers with hypertension, 18.1% reported high caregiver strain. Caregivers with high strain versus those with none/some were less adherent to the DASH diet (50.8% versus 38.9%,
P
<0.002), physically inactive (44.4% versus 36.2%,
P
<0.009), current smokers (19.7% versus 13.9%,
P
<0.004), and had lower overall self‐care scores (6.6 [SD 1.7] versus 7.0 [SD 1.7],
P
<0.001). In an age‐adjusted model, high caregiver strain was associated with worse hypertension self‐care (β=−0.37 [95% CI, −0.61 to −0.13]); this remained significant but was reduced in magnitude after adjustment for sociodemographics (β=−0.35 [−0.59 to −0.11]), comorbidities (β=−0.34 [−0.57 to −0.10]), caregiving intensity (β=−0.34 [−0.59 to 0.10]), and psychological factors (β=−0.26 [−0.51 to 0.00]).

Conclusions

High caregiver strain was associated with worse hypertension self‐care overall and across individual domains. Increased awareness of caregiver strain and its potential impact on hypertension self‐care is warranted.
Reduced Capacity of High‐Density Lipoprotein to Acquire Free Cholesterol From Triglyceride‐Rich Lipoproteins Is Associated With Elevated Postprandial Hypertriglyceridemia in Healthy Men
Authors: Galier Sophie , Darabi Maryam , Ma Feng , Materne Clément , Guillas Isabelle , Le Goff Wilfried , Kontush Anatol , Guerin Maryse
Published: July 2024

Background

The capacity of high‐density lipoprotein cholesterol (HDL) to acquire free cholesterol (FC) from triglyceride‐rich lipoproteins during lipoprotein lipase–dependent lipolysis in a process of reverse remnant cholesterol transport, has been proposed as a key biological function of HDL particles that underlies the U‐shaped relationship between HDLcholesterol and cardiovascular diseases. Although reverse remnant cholesterol transport has been evaluated in a fasting state, it has never been explored under nonfasting conditions.

Methods and Results

FC transfer was evaluated in healthy men (n=78) before and throughout the postprandial phase up to 8 hours after consumption of a test meal. Postprandially, the capacity of HDL to acquire FC increased progressively, reaching a maximal mean value of 98.5%±22.5% 6 hours after meal intake (
P
<0.05). Analysis of the study population according to tertiles of postprandial variation of FC transfer identified subjects exhibiting reduced capacity of HDL to acquire FC (tertile 1), those for whom the capacity of HDL to acquire FC remained unchanged (tertile 2), and subjects characterized by an enhanced FC transfer during the postprandial phase (tertile 3). Across the tertiles, we found an inverse relationship between the maximal postprandial change in FC transfer to HDL and the degree of postprandial triglyceride response.

Conclusions

Healthy individuals exhibiting exacerbated postprandial triglyceride response and reduced HDL cholesterol levels feature reduced FC transfer to HDL during the postprandial state. These data suggest that to normalize postprandial triglyceride response, 2 conditions need to be fulfilled: notably elevated FC transfer to HDL in the postprandial phase and increased levels of acceptor HDL particles.
Revascularization Therapies for Ischemic Stroke and Association With Risk of Epilepsy: A Danish Nationwide Register‐Based Study
Authors: Ebbesen Mads Qvist Buur , Dreier Julie Werenberg , Lolk Kasper , Andersen Grethe , Johnsen Søren Paaske , Zelano Johan , Christensen Jakob
Published: July 2024

Background

The association between stroke revascularization therapies and poststroke epilepsy is only sparsely investigated, and results are conflicting. The aim of this study is to investigate whether stroke revascularization therapies are associated with different risks of poststroke epilepsy.

Methods and Results

We conducted a nationwide, register‐based, propensity score–matched cohort study. We identified 40 816 patients admitted with a first ischemic stroke and no prior history of epilepsy in Denmark between January 1, 2011, and December 16, 2018. Of these, 6541 were treated with thrombolysis, 379 with thrombectomy, and 1005 with both thrombolysis and thrombectomy. The 3 treatment groups were each matched 1:1 to patients with stroke not treated with revascularization. Exact matching was done for sex, while propensity scores included information on stroke severity, cortical involvement, age, comorbidities, and socioeconomic parameters. Outcome was any diagnosis of epilepsy. We used Cox regressions to estimate adjusted hazard ratios (HRs) of epilepsy after ischemic stroke. Compared with matched patients with ischemic stroke not receiving revascularization treatment, patients who received thrombolysis alone had 32% lower risk of epilepsy (adjusted HR, 0.68 [95% CI, 0.57–0.81]) and patients who received thrombolysis and thrombectomy had 45% lower risk of epilepsy (adjusted HR, 0.55 [95% CI, 0.41–0.73]). Thrombectomy alone was not associated with significantly lower risk of epilepsy compared with matched patients with ischemic stroke not receiving revascularization therapy (adjusted HR, 0.78 [95% CI, 0.57–1.29]).

Conclusions

Thrombolysis alone and in combination with thrombectomy in ischemic stroke was associated with lower risk of epilepsy, whereas thrombectomy alone was not associated with lower risk of epilepsy.
Afet Dönemlerinde Sosyal Medyada Dezenformasyonun Yayılımı: 6 Şubat 2023 Kahramanmaraş Depremleri Örneği
Authors: Arklan Ümit , Koçyiğit İrem
Published: July 2024

Çalışmanın amacı, olağandışı koşulların yaşandığı afet dönemlerinde sosyal medya ortamlarında dezenformasyonun yayılımını Teyit.org üzerinden 6 Şubat 2023 Kahramanmaraş depremleri örneğinde incelemektir. Bu doğrultuda, 6 Şubat-6 Nisan 2023 tarih aralığında iki büyük depreme ilişkin 101 dezenformasyon içeriği analiz edilmektedir. Nicel içerik analizinin kullanıldığı çalışmadan elde edilen bulgular neticesinde dezenformasyona en fazla yer veren platformun X, dezenformasyonun en fazla etkileşim aldığı platformun ise TikTok olduğu görülmektedir. Söz konusu dezenformasyonlar, en çok yardım faaliyetleri ve depremin yıkıcılığına ilişkin konularda üretilmekte, dezenformasyon içeriklerinin konusu ise sosyal medya platformları arasında farklılık göstermektedir. Buna göre, X’te yardım faaliyetlerine yönelik dezenformasyonlar yaygınken TikTok’ta depremin yıkıcılığına dair dezenformasyonlar ön plandadır. Ayrıca, ilgili dönemde paylaşılan içeriklerde yanlış bilgi türü açısından bir farklılık görülmemekte, hatalı ilişkilendirmenin en çok başvurulan dezenformasyon türü olduğu anlaşılmaktadır.
Sürdürülebilirlik Perspektifinden Menü ve Reçetelerde Filizlendirilmiş Gıdalar
Authors: Yıldız Nezaket , Akyurt Kurnaz Hande
Published: July 2024

Bu araştırmanın amacı, filizlendirilmiş gıdaların restoranlarda; sürdürülebilir reçete ve menülere ne ölçüde yansıdığının belirlenmesidir. Ayrıca filizlendirilmiş gıdaların Ankara’da bulunan fine-dining, plant based mutfaklarda kullanım alanlarını belirlemek hedeflenmiştir. Araştırmada literatür taramasının ardından, yarı yapılandırılmış görüşme tekniği ile elde edilen veriler nitel araştırmalarda kullanılan yazılım programı MAXQDA 2022’den yararlanılarak analiz edilmiştir. Filizlendirilmiş gıdaların özellikle üst düzey olarak nitelendirilen restoranlarda kullanıldığı tespit edilmiştir. Birçok beslenme biçimi ile uyumlu olan filizlendirilmiş gıdalar; gıda hassasiyetlerinin yaygın olduğu ürünlere alternatif olabilmesi açısından sürdürülebilir ürün olarak nitelendirilmiştir. Filizlendirilmiş gıdaların özellikle özgün reçete anlayışını benimsemiş, yeni nesil restoranlarda farklı formlarda ve çeşitlerde kullanıldığı, tüketicilerce alternatif bir beslenme tarzı olarak beğenildiği ortaya çıkmıştır. Ayrıca filizlendirilmiş gıdaların gıda sanayisinde ve yeni nesil restoran kavramları ile güvenli gıdaya ulaşmada bir basamak olması ile ilgili araştırma sonuçlarıyla doğru orantılı önerilerde bulunulmuştur.
Akıllı Telefon Bağımlılığı ve Ruh Hali Düzenlemenin Akış Deneyimi Aracılığı ile Çevrimiçi Anlık Satın Alma Davranışındaki Rolü
Authors: Berk Özsev , Altunışık Remzi , Sarıkaya Nilgün
Published: July 2024

Bu çalışma; akıllı telefon bağımlılığı ve ruh hali düzenleme değişkenlerinin, akış deneyimi aracılığı ile çevrimiçi anlık satın alma davranışı üzerindeki etkilerini belirlemeyi amaçlamaktadır. Çalışmada geliştirilen model SOR (Uyaran-Organizma-Tepki) ve akış teorilerinden yararlanmaktadır. Araştırma bağlamında kolayda örnekleme yöntemi ile seçilmiş 609 katılımcı üzerinde yapılan çevrimiçi anket yönteminden elde edilen veriler kullanılmıştır. Verilerin analizinde SPSS 27 ve AMOS 26 programları kullanılmıştır.
Araştırma bulgularına göre; akıllı telefon bağımlılığı ve ruh hali düzenlemenin akış deneyimi üzerinde pozitif yönlü etkilerinin olduğu, çevrimiçi satın alma davranışı üzerinde ise doğrudan etkilerinin olmadığı sonucu ortaya çıkmıştır. Bununla birlikte akış deneyiminin, çevrimiçi anlık satın alma davranışı üzerinde pozitif yönlü etkisinin olduğu tespit edilmiştir. Ayrıca akıllı telefon bağımlılığı ve ruh hali düzenlemenin çevrimiçi anlık satın alma davranışı üzerinde etkilerinin akış deneyimi aracılığı ile anlamlı olduğu saptanmıştır.
Bir Maddi Kültür Ögesi Olarak Divanlarda Halhalın Sesini Duymak ve Pırıltısını Görmek
Authors: Çetin Kamile
Published: July 2024

Klasik Türk şiirinde divanları oluşturan gazel, kaside, mesnevi gibi farklı nazım şekilleriyle kaleme alınan şiirlerde oldukça geniş bir malzeme yelpazesinden istifade edilmiştir. Bu bağlamda hem kadınlar hem de erkekler tarafından kullanılan çeşitli takı ve aksesuarlar da şiirlere konu olmuştur. Bahsi geçen takılardan biri de halhaldır. Farklı yüzyıllara ait birçok divanın taranması neticesinde şairler tarafından halhalın geniş şekilde ve farklı ilgiler bağlamında söz konusu edildiği görülmüştür.
Makalede, Klasik Türk edebiyatında şairlerin bir takı olarak halhalı hangi özellikleriyle şiirlerinde konu ettikleri üzerinde durulmuştur. Bazen sesi, bazen yapıldığı malzemenin cinsi, gelinlerin süslenmesinde kullanılması, kuşlara, develere takılması gibi reel özellikleriyle ele alınmıştır. Diğer taraftan, halhalın tezyininde firuze, yakut gibi değerli taşlardan yararlanılması da şiirlere konu olmuştur. Bunların dışında, hilâl, arş, felek, sevgili, âşık, şairlik kudreti vb. unsurlar için teşbih veya mukayese vasıtası olarak değerlendirilmiştir.
Bankalar ve Sigorta Şirketlerinin Finansal Performansının VZA ve Malmquist Verimlilik Endeksi ile Belirlenmesi Üzerine Bir Araştırma
Authors: Bolat İsmet
Published: July 2024

Bu çalışmanın amacı 2018-2022 yılları arası Türkiye’de faaliyet gösteren Mevduat Bankaları ile Sigorta şirketlerinin finansal performanslarının ölçülmesi ve hangi şirketlerin daha verimli çalıştığının tespit edilmesidir. Çalışmada analiz yöntemi olarak; Veri Zarflama Analizi (VZA), Süper Etkinlik modeli ve Malmquist Toplam Faktör Verimlilik Analizi kullanılıştır.

Araştırmaya Türkiye’de faaliyet gösteren ve en büyük aktiflere sahip 5 Banka ile 5 Sigorta şirketi dahil edilmiştir. Analizde 2 girdi değişken; (Toplam Aktifler ve Özsermaye) ile 1 çıktı değişken; (Net Kar) kullanılmıştır. Analiz 5 yıllık periyot için, girdi odaklı sabit ve değişken getirili ölçek değerleri ayrı ayrı hesaplanmıştır. Çalışma sonucunda VZA ((I-V) ve (I-C)) sonuçlarına göre sigorta şirketlerinin bankalara göre daha yüksek bir etkinlik oranı yakaladıkları tespit edilmiştir. Ayrıca analize dahil edilen firmaların ortalama bazda toplam faktör verimliliğini yakaladıkları görülmüştür.
G-20 Ülkelerinde Ekolojik Vergilerin Karbon Emisyonları Üzerindeki Etkisi: Panel ARDL Analizi
Authors: Kurt Mustafa
Published: July 2024

Çalışmanın temel hedefi, çevre politikalarının etkinliğini ve sürdürülebilirlik hedeflerine ulaşmada ekolojik vergilerin potansiyel rolünü ortaya koymaktır. Bu çerçevede, 2006-2020 dönemine ait G-20 ülkelerinin yıllık verilerinden faydalanarak panel ARDL analizi yöntemi kullanılmaktadır. Bulgular, uzun dönemde ekolojik vergilerin karbon emisyonlarını negatif etkilediğini ve istatistiki açıdan anlamlı olduğunu göstermektedir. Öte yandan, bulgular, kısa dönemde ekolojik vergiler karbon emisyonları ilişkisinin istatistiki açıdan anlamsız olduğunu göstermektedir. Bu sonuçlar, mevcut ekolojik vergi yapısının karbon emisyonlarını azaltmada uzun dönemde yeterli olduğunu gösterirken Pigovian vergilerinin teorik çerçevede öngörüldüğü şekilde etkin olduğunu göstermektedir. Bu kapsamda, ekolojik vergilerin yeniden yapılandırılması, piyasa tabanlı mekanizmaların geliştirilmesi ve yeşil teşviklerin verilmesi gibi politikaların etkinliğinin artırılması küresel düzeyde karbon emisyonlarını daha fazla azaltabilir.
Informing the Public on Disaster Management: Evaluation of the Disaster and Emergency Management Presidency (AFAD) Press Releases
Authors: Atalay Ezgi , Gündüz Fatma , Aslan Ramazan , Usta Galip
Published: July 2024

It is aimed to evaluate the data in the press releases created by AFAD in order for the public to reach transparent and accurate information after the Kahramanmaraş-centered earthquakes in Turkey. AFAD press releases shared with the public between 06.02.2023 and 01.03.2023 formed the data of the study. In the study, evaluations were made on Search and Rescue, health, shelter, burial and identification, number of injured and deceased. It has been determined that information is provided regularly in the press releases, from the number of search-and-rescue personnel sent to the region, to meeting the shelter needs, from the number of deaths to the number of injured. The Disaster and Emergency Presidency's sharing of accurate and reliable information in informing the public in disasters plays an important role in ensuring public order.
Birinci Dağlık Karabağ Savaşı ve Azerbaycan-Türkiye Siyasi İlişkileri
Authors: Özsoy Bahar
Published: July 2024

1991 yılındaki bağımsızlığın ardından siyasi ve ekonomik bir kriz yaşayan Azerbaycan Dağlık Karabağ üzerindeki hak iddiası nedeniyle de Ermenistan’la savaşmak zorunda kalmıştır. Bu dönemde ülkedeki siyasi istikrarsızlık savaşın alanını genişletirken Azerbaycan’ın küresel alana entegrasyonunu geciktirmiştir. Nitekim, 1994 yılındaki ateşkes anlaşmasına kadar Dağlık Karabağ’ın yanı sıra çevre kentler işgal edilmiş ve Azerbaycan uluslararası kamuoyundan gereken desteği alamamıştır. Bununla birlikte, Türkiye 1991 yılında Azerbaycan’ı tanıyan ilk ülke olmuş ve kısa süre içerisinde diplomatik ilişkiler kurulmuştur. Siyasi ve ekonomik olarak Azerbaycan’ın yanında olan Türkiye Karabağ meselesinin çözülmesi konusunda Bakü yönetimine önemli bir destek sağlamıştır. Bu çalışma Azerbaycan-Türkiye siyasi ilişkilerinin temelinin oluşturulduğu ilk 10 yıllık dönemi incelemektedir. Çalışma ile iki ülke arasında “Dağlık Karabağ meselesi” üzerine inşa edilen siyasi ilişkilerin ateşkes anlaşması sonrasında Azerbaycan’ın uluslararası alana entegre edilmesi amacına evrildiğine dikkat çekilmektedir.
The Military Coup in Niger Republic
Authors: Sowale Adetayo Olamide
Published: July 2024

On 26 July 2023, Mohamed Bazoum, President of Niger, was deposed by a military coup masterminded by members of his presidential guard. The military junta dissolved the government and on 28 July General Abdourahmane Tchiani, head of the presidential guard, was pronounced Niger’s military leader. Since the coup, there have been widespread responses and reactions (local and international) to the political developments in the Niger Republic. This article uses secondary sources of data to argue that the coup was not an expression of displeasure against democracy, neither did it show solidarity for an authoritarian system. It was a symptom of the failure of democracy, including the operations of its proponents (the West, and France in particular) in the Sahel. The widespread jubilation emanated from the hope that the military leadership would put in place measures to ameliorate the security and economic woes of the country. The study concludes that the security and socioeconomic improvement of the Niger Republic is not tied to either a democratic or autocratic system of government, as proclaimed in international politics by the West, especially the US and France, and Russia and China.
Naturalizing Nous? Theophrastus on Nous, Nature, and Motion
Authors: Falcon Andrea , Roreitner Robert
Published: July 2024

There is prima facie evidence that Theophrastus naturalized nous to the extent that he spoke of it in naturalizing terms. But our evidence also suggests that Theophrastus accepted the reasons Aristotle had for excluding nous from the reach of natural philosophy. We show that, far from revealing an inconsistency on Theophrastus’ part, this apparent tension results from a consciously adopted strategy. Theophrastus is developing one aspect of Aristotle’s account of nous he found underdeveloped and feared might be misunderstood, namely the infrangible organic unity of the whole human being, including its nous. That is why he insists that nous, although ‘from outside,’ is ‘grown together’ with us, why he speaks of it as a nature (phusis), and why he insists that thought is a motion (kinêsis). We show how these striking claims can be understood against the broader background of Theophrastus’ natural philosophy.
Sacred Sorrow, Sacred Joy
Authors: Woodward Tanya Jo
Published: July 2024

The Psalmic is less tidy and linear than popular interpretation, and author Edwidge Danticat explores the non-linear tensions between lament and joy. Her writing is cyclical rather than linear. As Danticat explores the individual and communal juxtaposition of tragedy and celebration, her writing echoes the varied tenor and emotions of the Psalms. Haunting tales of national and personal life and death, separation and reunion are structurally played across her works. The heartrending sequence of life and death is eloquently explored through personal stories set against larger tales of Haitian immigration. Just as the Psalmist employs the vav adversative, or turning movements of joy and lament, Danticat likewise expresses her fluid engagement with the range of human experience (Card 75, 70). Danticat’s Psalmic aesthetic and her “fully awake and alive” wrestling with grief and celebration helps readers reconsider personal and national tragedy and triumph.
Daniel 4 and the Cultural Schema of the Akītu-Festival
Authors: Buster Aubrey E. , Walton John H.
Published: July 2024

The king’s condition in Dan 4 has invited significant discussion. Proposed interpretations of the king’s condition in Dan 4 include various medical diagnoses, imagery from the underworld, primitive uncivilized behavior, or imagery associated with divine displeasure and affliction. The current study argues, however, that the key to interpreting these images should be found in the passage’s connection to one of the most prominent rituals of royal legitimation in ancient Mesopotamia, the akītu-festival. The akītu-festival celebrated the divine legitimation of the king through a ritual of 1) the king’s loss of royal status before it is returned; 2) a decree of destiny; and 3) a dramatic exit and re-entry into the city as a symbol of exit and re-entry into the ordered world. It is within the narrative arc of this festival that the animalian imagery of Dan 4 finds its most compelling explanation.
Worldview, Conflicting Spiritualities and Religious Ecology in Nigeria
Authors: Adebayo Francis Kehinde
Published: July 2024

This article contributes to the religion and environment field by analyzing the environmental impact of two divergent ethical responses within Nigerian Christianity. Based on different interpretations of a specific aspect of African spiritual cosmologies, African Indigenous churches (AIC s) and African independent Pentecostals (AIP s) in Nigeria have formulated conflicting spiritualities that shape their ecotheologies. Based on this same cosmology, the ecotheology of the AIC s shows continuity with the indigenous notion of sacred space which also encourages the preservation of the ecosystem especially trees and wet forests. The AIP s, on the other hand, interpret the same notion differently by segregating the public space into holy and evil ecologies. To rid these habitats of perceived evil spirits in the ecosystem, some AIP s have constructed a theology of evangelism and spiritual warfare to expel these spirits by destroying their habitats and converting such habitats into holy use such as building churches and prayer camps. Based on data obtained through observation and literature, the proliferation of prayer camps along the Lagos-Ibadan Expressway is analysed as a product of these notions of holy and evil ecologies.
Shy–bold behaviours in dragonfly larvae: syndromes or personality?
Authors: Zenni Tatiene M. , Crivelaro Amanda Z. , Pestana Gabrielle C. , Guillermo-Ferreira Rhainer
Published: July 2024

Researchers have recently focused efforts on the study of animal personality and behavioural syndromes, exploring consistent behaviour variations and correlations. Dragonflies, with their diverse behaviours, have become good models to improve our knowledge on animal behaviour. Here, we addressed whether dragonfly larvae exhibit shy–bold behaviours, akin to personality traits or behavioural syndromes. We made a series of experiments where we restrained larvae and noted their behaviour — some larvae exhibited thanatosis, playing dead when touched, while others boldly reacted with aggression. Later, we tested how active the larvae were in a water channel by analysing their movement. These experiments were made in three trials with 15 days apart. Our results show that larvae display consistent behaviours over time, hence, they exhibit personalities in terms of predator avoidance behaviour. Nevertheless, we found little evidence for behavioural syndromes. The boldness of larvae was only partially correlated with larval activity in the experimental channel. In conclusion, dragonflies emerge as a potential model for insect personality, prompting future studies on how cognition and personality impact fitness in different environments. Unravelling whether behavioural syndromes are a true phenomenon in these insects awaits further investigation.