bluuebunny/crossref_metadata_2025 huggingface dataset:
“Diversity makes the richness of humanity”: the emergence of mental imagery after self-reported psilocybin mushrooms intake in an autistic woman with “blind imagination” (aphantasia): a 1-year retrospective case report
Authors: Rebecchi Kevin
Published: August 2023

This retrospective case report explores the impact of psilocybin mushroom intake on the emergence of mental imagery in an autistic woman with aphantasia. Aphantasia refers to the inability to generate visual mental images, which can significantly affect individuals' experiences and cognitive processes. The case study focuses on a 34-year-old autistic woman who had been living with aphantasia since childhood. After consuming psilocybin mushrooms, she reported experiencing vivid mental imagery for the first time, with the ability to manipulate and explore images in her mind. The effects persisted even after the psychedelic effects of psilocybin subsided. The woman's retrospective assessment using the Vividness of Visual Imagery Questionnaire revealed a significant increase in imagery vividness scores post-intake. The findings align with previous research on the effects of psilocybin on brain connectivity, neuroplasticity, and visual processing. The case report highlights the potential of psilocybin to modulate mental imagery in individuals with aphantasia and suggests avenues for further research. Moreover, it raises questions about the classification and pathologization of aphantasia, emphasizing the importance of recognizing cognitive diversity and promoting the well-being of individuals with different cognitive profiles, including aphantasia.
Loneliness, depression and entrapment during lockdown: a cross-national investigation of COVID-19 related problems over time in suicide prevention helplines
Authors: van der Burgt Margot C. A. , van Eijk Nikki Lyka , Mérelle Saskia , De Jaegere Eva , Pauwels Kirsten , Portzky Gwendolyn , Gaer Eva Vande , Beekman Aartjan , Schweren Lizanne , Gilissen Renske
Published: August 2023

Intro: During the COVID-19 pandemic a collaboration was established between two suicide prevention helplines in The Netherlands and Belgium. The aim was to explore: (i) the nature of COVID-19-related conversations and differences between the countries (ii) whether sociodemographic factors and government restrictions could predict the number of COVID-19-related conversations, and (iii) how the prevalence of COVID-19-related problems progressed over time. Method: A cross-national longitudinal observational design, using registration data from the two helplines in the Flemish-speaking part of Belgium (N = 9,352) and the Netherlands (N = 20,826). Results: Most reported COVID-19-related problems were loneliness, increases in feelings of depression/ anxiety and entrapment. Men, those over the age of 30, people living alone, and those not in regular mental healthcare were more likely to discuss COVID-19-related problems. Stricter government regulations significantly predicted COVID-19-related conversations, however, the effect size was small. Some problems stayed stable over time, whereas feelings of depression/anxiety, entrapment and loneliness peaked during stricter lockdown measures. Conclusion: The high prevalence of feelings of loneliness and the increase in feelings of entrapment during periods with stricter lockdown measures is of particular relevance for future crises. Care should be taken to provide additional support and monitoring of vulnerable groups.
Identifying Metadata Quality Issues Across Cultures
Authors: Shi Julie , Nason Michael , Tullney Marco , Alperin Juan Pablo
Published: August 2023

Metadata serve discovery and access by providing contextual, technical, and administrative information in a standard form. Yet metadata are also sites of tension between sociocultural representations, resource constraints, and standardized systems. Formal and informal interventions may be interpreted as quality issues, political acts to assert identity, or strategic choices to maximize visibility. We therefore sought to understand how metadata quality, consistency, and completeness impact individuals and communities. By reviewing a non-random sample of 427 records, we identified 32 unique issues and classified them into 5 categories to better explain how metadata and communities press up against each other to intentionally reflect (or not) cultural meanings.
के तिमीले मलाई आविष्कार गर्यौ ? कवितामा लयविधान
Authors: गुरुङ Gurung गौरीसरा Gourisara
Published: August 2023

‘के तिमीले मलाई आविष्कार गर्यौ ?’ कवि सरिता तिवारी (२०७२) द्वारा लिखित लामो गद्य कविता हो । नारी अस्तित्वको पक्षमा लेखिएको यो कविताप्रश्नहरूको कारखाना (२०७२) कवितासङ्ग्रहमा समेटिएको छ । २४९ शब्द, ५७ पङ्क्ति र ११ अनुच्छेदमा संरचित यस कविताको लय विधानको अध्ययनका लागि लयविधानको विभिन्न सैद्घान्तिक आधारहरू पङ्क्तिविन्यास, समानान्तरता, विचलन, विपरितता,खण्डीकरण, सम्बोधन र लेख्यचिह्नहरूलाई आधार लिइएको छ ।
CRITIQUE OF THE STRATA MANAGEMENT ACT’S ‘SOCIAL LEGISLATION’ PURPOSE IDENTIFIED IN INNAB SALIL v VERVE SUITES MONT’ KIARA [2020] 12 MLJ 16 (FC)
Authors: Wong Jing Zhi
Published: August 2023

This case note provides a critique of the ‘Social Legislation’ purpose of the Strata Management Act 2013 identified in Innab Salil & Ors v Verve Suites Mont’ Kiara [2020] 12 MLJ 16 (‘Verve Suites’). This case note suggests that the ‘social legislation’ purpose identified in Verve Suites achieved two purposes. First, it identified the Act’s broad legislative purpose and guided its statutory interpretation. Second, it provided a normative rationale which justified why it should be read as taking precedence over other legislation. However, it is suggested that the words ‘social legislation’ applied to the Strata Management Act 2013 may be a misnomer. It is proposed that the Federal Court should reconsider a restatement of its findings on the ‘social legislation’ purpose of the Strata Management Act 2013.
LAMA WAKTU PERENDAMAN BIJI PALA (Myristica fragrans H.) DENGAN PENAMBAHAN KALIUM NITRAT (KN03) TERHADAP PERKECAMBAHAN BIJI
Authors: Zahra Savanah , Isda Mayta Novaliza
Published: August 2023

Myristica fragrans Houtt.  is a spice plant that is used as a spice in the kitchen, food preservatives, beverages, perfumes, cosmetics and soaps. The large use of nutmeg plants results in high industrial demand for nutmeg but the availability of nutmeg is minimal because generative propagation using seeds is still constrained because the structure of the seed coat is hard so that germination takes up to 8 weeks. Dormancy breaking can be done with chemical compounds such as the use of KN03 (potassium nitrate). This study aims to determine the effect of soaking time of nutmeg using KN03 solution and determine the efficient time of soaking nutmeg using KN03 solution on germination. This study used a completely randomized design (CRD) which consisted of 5 levels of immersion time, namely without immersion KN03, immersion 12 hours, 24 hours, 36 hours and 48 hours. Parameters observed were germination percentage and germination time. Data were analyzed using ANOVA at 5% level and DMRT follow-up test. The results showed that the duration of soaking nutmeg seeds using KN03 had a significant effect on the percentage of germination and germination time. The treatment of soaking nutmeg seeds with 2% KNO3 for 24 hours was an efficient treatment for nutmeg seed germination with a germination percentage of 88.3% and germination time of 23.7 days.
Repliken
Authors: Müller Olaf
Published: August 2023

Diese klugen Reaktionen auf mein Buch unterscheiden sich erheblich. W??hrend Susanne Burri mit meiner Grundthese sympathisiert und mir in deren Rahmen zwei knifflige Probleme vorlegt, die sich konstruktiv bearbeiten lassen, geht Christoph Lumers Kritik ans Eingemachte: Im Rahmen des
von ihm bevorzugten philosophischen Ansatzes stellt sich meine Herangehensweise als haltlos dar, weil ihr jede Rationalität abgeht.
Resultados Tardios do Tratamento do Câncer da Bexiga
Authors: Vianna João B.
Published: August 2023

O A. apresenta sua experiência pessoal com resultados tardios em 132 pacientes operados de câncer da bexiga. Cerca de 41% eram de casos avançados dos estádios T-4. Do total de 132 doentes, 14 sobreviveram à operação de 5 a 15 anos, ora sem apresentar sinais de câncer em evolução, ora apresentando metástases ósseas tardias, ora outro tipo histológico de câncer em outras vísceras, o que leva o A. a um certo cepticismo quanto à cura verdadeira do câncer vesical com os meios de tratamento atuais. Além disso, acha que o urólogo deverá agir com muito discernimento e precaução para não causar aos pacientes, com o tratamento mutilante, um sofrimento igual ou maior do que aquele causado pelo próprio câncer.
Prótese Nasal Para Uso Noturno
Authors: Rezende José Roberto Vidulich de
Published: August 2023

O Autor, neste trabalho, salienta os problemas inerentes à confecção de uma prótese facial, destacando aqueles referentes ao seu uso durante o período "noturno". Propõe método de confecção de prótese nasal de recobrimento em PVC resiliente, utilizando aparelho Omnivac IV, usado em prótese dental na construção de vários aparelhos. Após a descrição do método, conclui que este ofereceu uma série de vantagens. Os portadores destas próteses mostraram-se satisfeitos, e sob o ponto de vista do autor o único inconveniente é ser o material incolor.
Carcínoma Epídermóíde do Pênis. Freqüêncía de Casos nos Últimos 10 (dez) Anos no Hospital do Câncer de Pernambuco
Authors: Cunha Ruy Pinto
Published: August 2023

O carcinoma epidermóide do pênis apresenta uma alta freqüência no Estado de Pernambuco. Num período de 10 (dez) anos, isto é, de janeiro de 1963 a dezembro de 1972, foram admitidos e tratados dessa doença no Hospital do Câncer de Pernambuco, num total de 354 pacientes, a maioria em estádio clínico avançado. Embora o nosso estudo seja restrito a um único hospital, acreditamos representar uma amostragem bem significativa da situação no Estado de Pernambuco, uma vez que se trata de um hospital especializado no tratamento do câncer, que recebe pacientes de todas as cidades do interior e encaminhamento dos principais hospitais da Capital. Os trabalhos publicados a respeito do assunto são unânimes em referir que o câncer do pênis é de elevada freqüência nas regiões de baixo nível sócio-econômico, e, ao contrário, de baixa freqüência nas regiões desenvolvidas, isto é, de bom nível sócio-econômico. Fato importante assinalado pelos autores é a presença de fimose na maioria dos pacientes, e a quase inexistência da doença entre os povos que se submeteram à circuncisão na infância.
ТЕОРЕТИЧНЕ ПІДГРУНТЯ РЕАЛІЗАЦІЇ СОЦІАЛЬНОЇ КОМУНІКАЦІЇ
Authors: Шегинська Наталія , Тимкович Оксана
Published: August 2023

Ця стаття узагальнює теоретичні основи визначення соціальної комунікації. Основною метою проведеного дослідження є виокремлення характерних ознак та концептуальних основ соціальної комунікації. Актуальність дослідження визначається постійно зростаючою потребою у використання нових засобів комунікації з метою поширення інформації за наявності дистанційної зайнятості, глобалізаційних зрушень, економічних та політичних потрясінь. Дослідження теоретичних основ поняття соціальної комунікації здійснюється на основі виокремлення теоретичних конструкцій, рівнів, функцій та засобів спілкування. Методичним інструментарієм проведеного дослідження стали історичний та логічний методи, графічний метод, методи аналізу та синтезу – для формування базових основ соціальної комунікації. Об’єктом дослідження обрано особливості, засоби та інструментацій соціальної комунікації. Результати проведеного дослідження можуть бути корисними для побудови внутрішньо особистісного та міжособистісного спілкування.
УПРАВЛІННЯ АУТСОРСИНГОМ: ТЕОРЕТИЧНІ АСПЕКТИ
Authors: Крисак Алла , Крисак Андріан
Published: August 2023

У статті вивчено та ознайомлено з теоретичними аспектами управління аутсорсингом, обгрунтувано та узагальнено існуючі підходи до змістовного поняття аутсорсингу. Наголошено, що нині все ширшого значення набуває потреба у застосуванні новітніх шляхів та методів управління на засадах сорсингових та крауд-технологій таких як аутсорсинг, краудсорсинг тощо. Ознайомлено з існуючими визначеннями термінології «аутсорсингу» у вітчизняних та зарубіжних економічних тлумачниках, науковим доробком вчених-економістів, вивчено теоретичні аспекти управління аутсорсингом, обґрунтовано та узагальнено окремі підходи до змістовного наповнення аутсорсингу. Відтак, уточнено, що аутсорсинг – це інструмент управління, що враховує організаційну функцію щодо прийняття рішення шляхом оптимізації виробництва через делегування повноважень, функцій, відповідальності незалежній сторонній організації на договірних засадах, що забезпечить фокусування на ключовій цілі високоефективної та конкурентоспроможної компанії.
СОЦІАЛЬНА ПОЛІТИКА ЯК СКЛАДОВА ДЕРЖАВНОГО УПРАВЛІННЯ В УМОВАХ ЗМІН
Authors: Савченко Ольга
Published: August 2023

Мета статті полягає у вивченні й аналізі сутності, вагомості та особливостей сучасної соціальної політики як складової внутрішньої політики держави – визначені принципів, пріоритетів та напрямів розвитку соціальної сфери. Вона спрямована на забезпечення добробуту громадян через надання їм можливості отримати необхідні блага. Першочерговість інтересів та захист суспільства з боку державної влади, формують їй привабливий імідж сучасної, проєвропейської держави з демократичними цінностями. Якісна соціальна політика вирішальною мірою впливає на її міжнародне партнерство, особливо у боротьбі з росією через політичну, фінансову, гуманітарну та соціальну допомоги. У статті запропоновано визначення поняття «соціальна політика» на основі аналізування змістового наповнення досліджуваної категорії. Зосереджено увагу на трансформації державного управління в публічне через упровадження сучасних підходів New Public Management (NPM-модель), Good Governance (GG-модель), «електронний уряд» (DG: e-governance) та інших, які зосереджені не на процедурах та процесах, а результатах якості та ефективності, а головне – передбачають участь суспільства в політичних, економічних та соціальних процесах державотворення з метою підвищення власного добробуту, можливостей і особистісного потенціалу. У статті схематично подано першорядні ознаки соціальної політики (мета, завдання та напрями: політика розподілу і перерозподілу суспільного продукту, демографічна політика, політика зайнятості та охорони праці, політика соціального забезпечення і соціального страхування, політика гармонізації соціально-економічних інтересів і забезпечення соціального діалогу) та її ключові елементи (суб’єкт, об’єкт, принципи та зв’язки управління, функції та механізми реалізації соціальної сфери) як складової системи державного управління. Наведено пріоритетні напрями трансформації державної соціальної політики з урахуванням внутрішнього стану та змін країн ЄС в умовах глобалізаційних викликів. Визначено, що новітня політика системи соціального захисту має бути справедливою, адресною та економічно-ефективною, тобто враховувати соціально-економічне становище держави.
ДЕТЕРМІНАНТИ АДВОКАЦІЇ СТРАТЕГІЙ РОЗВИТКУ УКРАЇНСЬКИХ ЦИФРОВИХ РИНКІВ В УМОВАХ КОНКУРЕНТНИХ ТА БЕЗПЕКОВИХ ВИКЛИКІВ
Authors: Смерічевський С.Ф. , Поканевич Ю.В.
Published: August 2023

У статті охарактеризовано детермінанти адвокації стратегій розвитку українських цифрових ринків в умовах конкурентних та безпекових викликів. Визначено основні характеристики цифрових ринків. Проаналізовано напрями антиконкурентної поведінки гравців на цифрових ринках та запропоновано ряд заходів щодо боротьби з такими антиконкурентними практиками. Визначено та обґрунтовано економічні переваги інтегрування України до Єдиного цифрового ринку Європейського Союзу. Проаналізовано особливості та основні пріоритети стратегічного цифрового розвитку ЄС та обґрунтовано важливість їх імплементації в Україні. Проаналізовано рейтинг країн-членів ЄС за Індекcом цифрової економіки та суспільства. Визначено основні напрями співпраці Міністерства цифрової трансформації України та ЄС в контексті наближення до цифрового безвізу з ЄС. Обґрунтовано, що розвиток українських цифрових ринків є необхідною передумовою для підвищення рівня інноваційності та конкурентоспроможності вітчизняної економіки в сучасному цифровому світі.
Assessment of Engineering Properties of Artificial Aggregate Prepared From Canal Silt
Authors: Iqbal Safdar , Jehan Beenish , Khan Fasih Ahmed , Nasir Hassan
Published: August 2023

In this research the canal silt from the Kabul River Canal was recycled to manufacture artificial aggregate. For making artificial aggregates three batches were prepared each of dry weight of 100kg. The composition of artificial aggregate is Polyvinyl Alcohol (PVA), Ordinary Portland Cement (OPC) and Silt was mixed in different proportions (by weight). Three batches were made having values of PVA varying from 0, 1 and 2 percent, cement content was 20, 19 and 18 percent respectively, and the quantity of silt used was kept constant (80%) in each batch. Samples were prepared from these three different batches and were cured for 28 days. After completion of the curing time, they were crushed to get the desired course aggregate. A number of tests were performed to check the viability of artificial aggregates for being used as a lightweight aggregate. Shape and particles size distribution properties of artificial aggregates were as that of the natural aggregate but not satisfactory at high silt content. The reductions in the specific gravity of the artificial aggregate were also observed compared to natural aggregates.

 

Index Terms— Artificial Aggregates, Canal Silt, Coarse Aggregates, Lightweight Aggregates, Polyvinyl Alcohol (PVA).
Human Heart Disease Prediction System Using Data Mining Techniques
Authors: Javed Sidra , Javed Hamza , Saddique Ayesha , Rafiq Beenish
Published: August 2023

— Prediction of heart disease is a big concern now a days because everyone is busy and due to heavy load of work people do not give attention to their health. To diagnose a disease is a big challenge. The issue is to extract data that have some meaningful knowledge. For this purpose, data mining techniques are used to extract meaningful data. Decision Tree and ID3 are used to predict heart diseases. Many researchers and practitioners are familiar with prediction of heart diseases and wide range of techniques is available to predict disease. To address this problem, Decision Tree is used to predict the heart disease. In this study the collected data is pre-processed, Decision Tree algorithm and ID3 were then applied to predict the heart disease.

 

Index Terms— Decision Tree, ID3 Algorithm, Data Mining, Decision Support System (DSS), knowledge Discovery from Databases (KDD).
PENSAMENTO COMPLEXO, INTERDISCIPLINARIDADE E O PAPEL DO EDUCADOR-CUIDADOR
Authors: Rodrigues Farias Flavir , De Lima da Silva Leonardo Aparecido , Bolincenha Marcos Fernando , Souza Ribeiro Patricia Xavier de , Recalcatti Rosemery , Bonin Joel Cezar
Published: August 2023

Este artigo é resultado da produção conjunta entre estudantes do Programa de Pós-Graduação – Mestrado em Educação Básica (PPGEB) da UNIARP, campus de Caçador. Durante o desenvolvimento do presente texto, os colaboradores debateram sobre a premência das discussões sobre o pensamento complexo e a sua coligação com a visão interdisciplinar de produção do conhecimento. Nesse contexto, viu-se que o processo de produção deste trabalho deu-se de modo totalmente interdisciplinar, sendo que os envolvidos são formados em áreas diversas da licenciatura, tais como Pedagogia, História, Letras, Química e Matemática. Deste caleidoscópio de olhares, o texto apresenta a ideia de que vivemos em um mundo marcado até os ossos pela urgência de uma visão mais complexa, sistêmica e integradora dos conhecimentos de maneira que não se pode mais ver as partes sem conectá-las com o todo e vice-versa, sendo que por meio deste diapasão, é possível desenvolver em todo e qualquer educador uma responsabilidade ética do cuidado de si mesmo e dos alunos que estão sob seus auspícios. Esta pesquisa adotou o viés metodológico bibliográfico, de caráter qualitativo usando, sobremaneira, obras de Morin (1990, 2000, 2001), Fazenda (2008) e Foucault (1995).
Palavras-chave: Pensamento complexo. Interdisciplinaridade. Educação. Cuidado.
 
ABSTRACT
This article is the result of a collaborative effort among students from the Graduate Program – Master's in Basic Education (PPGEB) at UNIARP, Caçador campus. During the composition of this text, the contributors discussed the urgency of dialogues surrounding complex thinking and its alliance with the interdisciplinary approach to knowledge production. It became clear that the process of creating this work unfolded entirely in an interdisciplinary manner, involving individuals with diverse academic backgrounds in areas like Pedagogy, History, Literature, Chemistry, and Mathematics. From this kaleidoscope of viewpoints, the article posits that we inhabit a world deeply marked by the necessity for a more complex, systemic, and integrated understanding of knowledge. In such a world, it is impossible to consider the parts without connecting them with the whole, and vice versa. This holistic perspective enables the development of an ethical responsibility among educators for self-care and the care of students under their guidance. The research adopted a qualitative, bibliographic methodological approach, drawing heavily from the works of Morin (1990), Fazenda (2008), and Foucault (1995).
Keywords: Complex thinking. Interdisciplinarity. Education. Care.
AKCİĞER KANSERİ VE MEME KANSERİ HÜCRELERİNDE SAFRANAL BİLEŞİĞİNİN SİTOTOKSİK AKTİVİTESİNİN GERÇEK ZAMANLI İZLENMESİ
Authors: UZUNHİSARCIKLI Ebru
Published: August 2023

Amaç: Akciğer adenokarsinomu ve meme kanseri en sık görülen kanser türleridir ve dünya çapında kansere bağlı ölümlerin önde gelen nedenlerindendir. Safranal bileşiğinin çeşitli farmakolojik etkileri ve sitotoksik özellikleri vardır. Bu çalışmanın amacı, safranal bileşiğinin insan akciğer karsinomu hücre hattı (A549), insan meme kanseri hücre hattı (MCF-7) ve insan bronşiyal epitel sağlıklı hücre (Beas-2b) hatları üzerindeki sitotoksisitesini sürekli izleme yoluyla tahlil etmektir.
Gereç ve Yöntem: Hücreler, safranal ile 1, 10, 100 µM konsantrasyonda muamele edildi ve bu bileşiğin hücre canlılığı üzerindeki etkisini belirlemek için xCELLigence gerçek zamanlı hücre analizörü kullanılmıştır. E-plaka kuyularının empedansı aracılığıyla hücre indeksi görüntülenerek her 15 dakikada bir izlenmiştir.
Sonuç ve Tartışma: Yapılan çalışmalar sonucunda safranal bileşiğinin MCF-7 hücre hattı üzerinde sitotoksik etkiye sahip olduğu, A549 ve Beas-2b hücreleri üzerinde toksik etkisinin olmadığı belirlenmiştir. MCF-7 hücre hattında, hücre indeksi değişiklikleri, kontrol grubu ile karşılaştırıldığında tüm konsantrasyonlarda azaldığı tespit edilmiştir. Kanser türüne göre bu ilaçların etkinliğini artırmak için geleneksel antikanser ilaçlar ve safranal bileşiği kombinasyonu kullanılabilir.
TECNOLOGIAS DIGITAIS PARA O DESENVOLVIMENTO DO LETRAMENTO ESTATÍSTICO: PANORAMA DE PESQUISAS BRASILEIRAS DO PERÍODO ENTRE 2017 E 2022
Authors: Gomes Milena Vasconcelos , Souza Maria Silvania Marques Xavier de , Castro Juscileide Braga de
Published: August 2023

Este trabalho se caracteriza como um artigo de Revisão Sistemática de Literatura (RSL) e tem como objetivo compreender como as Tecnologias Digitais têm sido utilizadas para o Letramento Estatístico de alunos da Educação Básica. Para isso, realizou-se uma Revisão Sistemática de Literatura, de trabalhos brasileiros, no intervalo de tempo de 2017 a 2022, disponíveis na base de dados: Catálogo de Teses e Dissertações da CAPES. Como resultados destaca-se a utilização do Software GeoGebra, do objeto de aprendizagem Estatística Fácil e da Plataforma Khan Academy, como tecnologias digitais educacionais que possibilitam o desenvolvimento do Letramento Estatístico. Esta RSL revelou ainda o potencial de tecnologias digitais, não educacionais, como o Whatsapp, o Google Forms e as planilhas eletrônicas; pois foram usadas para favorecer o processo de planejamento, coleta e organização de dados. O manuseio desses recursos tecnológicos, somado ao planejamento e a escolha de estratégias pedagógicas adequadas podem colaborar para o desenvolvimento do Letramento Estatístico.
PROGRAMAÇÃO APLICADA AO ENSINO DE MATEMÁTICA SOB A PERSPECTIVA DA TEORIA DOS REGISTROS DE REPRESENTAÇÃO SEMIÓTICA: UMA EXPERIÊNCIA DIDÁTICA COM AS NOÇÕES DE VARIÁVEIS DEPENDENTE E INDEPENDENTE NA FUNÇÃO AFIM
Authors: Romana de Oliveira Santos Mônica , Fassarella Lúcio Souza
Published: August 2023

Apresentamos um recorte de uma pesquisa qualitativa com fins exploratório fundamentada teoricamente na Teoria dos Registros de Representação Semiótica e que teve como objetivo geral investigar as possíveis contribuições proporcionadas pelo uso da programação no ensino-aprendizagem de função afim. A pesquisa inclui a aplicação e análise de uma experiência didática realizada em 2021 com onze estudantes do primeiro ano do Ensino Médio de uma escola da rede pública estadual do Município de Teixeira de Freitas, Bahia. Nessa experiência, aplicamos uma sequência didática para o ensino do conceito de função afim em que os estudantes tiveram que resolver problemas utilizando a linguagem de programação Scratch. Da análise dos dados referentes a uma atividade dessa sequência, concluímos principalmente que as conversões envolvendo representações na língua natural e nos registros algébrico e computacional contribuem para compreensão de aspectos relacionados ao conceito de função afim, tais como a noção de variável, a relação de dependência entre grandezas, o uso de letras ou comandos para representar possíveis valores numéricos e também a realizar generalizações.
ENSINO-APRENDIZAGEM DE EQUAÇÕES DE 2º GRAU VIA RESOLUÇÃO DE PROBLEMAS: UMA EXPERIÊNCIA A PARTIR DE UMA TRAJETÓRIA HIPOTÉTICA DE APRENDIZAGEM
Authors: Francisco Pereira Fernando , Proença Marcelo Carlos de
Published: August 2023

O objetivo assumido neste artigo consiste em apresentar uma experiência de uso da Trajetória Hipotética de Aprendizagem no Ensino-Aprendizagem de Equações de 2º grau via Resolução de Problemas. Para isso construiu-se os referenciais teóricos sobre Trajetória Hipotética de Aprendizagem e o Ensino-Aprendizagem de Matemática via Resolução de Problemas, possibilitando traçar na metodologia uma Trajetória Hipotética de Ensino-Aprendizagem de Equações de 2º grau articulada em ambas as teorias. Tal trajetória foi aplicada em grupos de alunos do 9º ano. Os expostos constituíram-se dos registros das atividades desenvolvidas pelos alunos, dos questionamentos, dúvidas e resoluções que surgiram ao longo da proposta em articulação com as hipóteses elencadas a priori. Os resultados da articulação revelaram que: grande parte das atividades e incertezas dos alunos pode ser prevista e estabelecida soluções-base que amparam as explicações do professor; o problema como ponto de partida possibilita nortear e dinamizar o ensino de matemática atribuindo significado a aprendizagem do conteúdo articulando-o a um contexto.
A perspective: Regeneration of soft and hard tissues in the oral cavity, from research to clinical practice
Authors: Puterman Israel , Fien Matthew J. , Mesquida Juan , Ginebreda Ignacio , Bauza Guillermo , Somerman Martha
Published: August 2023

Regenerative medicine has gained much attention and has been a hot topic in all medical fields since its inception, and dentistry is no exception. However, innovations and developments in basic research are sometimes disconnected from daily clinical practice. This existing gap between basic research and clinical practice can only be addressed with improved communication between clinicians, academicians, industry, and researchers to facilitate the advance of evidence-based therapies and procedures and to direct research to areas of clinical need. In this perspective, six participants with strong clinical and research interests debated five previously conceived questions. These questions covered current methods and procedures for soft and hard tissue regeneration in the oral cavity with predictable outcomes, limitations of their respective protocols, and needs for future development of regenerative materials and technologies.
Comparing community-based reading interventions for middle school children with learning disabilities: possible order effects when emphasizing skills or reasoning
Authors: Archibald Lisa M. D. , Davison Christine , Kuiack Alyssa , Doytchinova Stella , King Colin , Shore-Reid Deborah , Cook Paul , Vollebregt Meghan
Published: August 2023

Introduction

There is an abundance of community-based reading programs for school-age children who are struggling learners. The aim of this study was to compare two community-based programs (i.e., skill and reason-based programs) and to analyze any complementary benefits.

Methods

In this randomized cross-over study, 20 children completed two 8-week literacy intervention programs. The skills-based program, Leap to Literacy, focused on explicit teaching and repeated practice of the five key components of literacy instruction (phonemic awareness, phonics, fluency, vocabulary, comprehension). The reason-based program, Wise Words, focused on morphological knowledge, hypothesis testing, and critical thinking.

Results

Results revealed study-wide improvements in phonemic awareness, nonword reading, passage reading accuracy, spelling words and features, and affix identification. There were consistent program by program order effects with robust effects of completing the skills-based program first for phonemic awareness, the reason-based program first for passage reading accuracy, and both programs for affix identification. A significant increase in an oral language measure, recalling sentences, was observed for the group who completed the reason-based program first, although they also started off with a lower initial score.

Discussion

Findings indicated improvements from participating in either program. The observed order effects suggest potential additive effects of combining reason- and skills-based approaches to intervention.
Three-peak evolution characteristics of supporting stress on a super-long working face in a thick coal seam
Authors: Wang Hongbing , Cheng Zhiheng , Zhang Jinhu , Chen Liang , Luo Xin , Li Meichen , Chen Haoyi , Xie Yifei
Published: August 2023

Increasing working face length is the development trend of intelligent and efficient longwall fully mechanized mining. By combining field measurement and theoretical calculation, change characteristics of the frequency, peak value, and range of weighting in a long working face in a 1000 m-deep shaft of Kouzidong Coal Mine (Fuyang City, Anhui Province, China) were studied. Based on the mechanical model of the hydraulic support group of the elastic independent support, force characteristics and posture change characteristics of the support in the 121304 working face of the mine were studied and analyzed. The supporting stress characteristics of the deep super-long working face were revealed, and the theoretical calculation was in good agreement with the actual measurement. Based on the aforementioned model, support parameters and control technology of the 140502 working face were studied. The results show that as the length of the working face increases, the supporting stress gradually transforms from a single peak to multiple peaks and expands to both ends of the working face. The weighting in different areas of the working face is characterized by an obvious time sequence and great difference in intensity. When the working face length is 300 m, the multi-peak characteristic of super-long working faces appears. The M-shaped three-peak characteristic can be used as the criterion for super-long working faces. A reasonable working face length should be determined by comprehensively considering occurrence conditions of coal seams, working face parameter, and equipment ability. According to the different attributes of hydraulic supports in space and function and combining with zonal characteristics of the long working face, the criterion for the super-long working face and the principle of zonal cooperative control of hydraulic support groups were revealed. In addition, a cooperative control method of equipment groups in the working face based on the state error and cost functions was put forward, and the three-level cooperative control strategy and implementation method were formulated. It can effectively guide the equipment group in the super-long fully mechanized working face in deep thick coal seams to achieve optimal coordinated control.
A suspension of inactivated bacteria used for vaccination against recurrent urinary tract infections increases the phagocytic activity of murine macrophages
Authors: Eggers Anja , Ballüer Melissa , Mohamed Belal A. , Nau Roland , Seele Jana
Published: August 2023

Background

Urinary tract infections are a major cause of the consumption of antibiotics in humans.

Methods

We studied the effect of a vaccine (StroVac®, containing inactivated bacteria and used to prevent recurrent urinary tract infections) licensed in Germany on the release of pro-inflammatory cytokines and the phagocytosis of Escherichia (E.) coli in primary murine macrophages and the macrophage cell line J774A.1.

Results

StroVac® increased the release of the cytokines TNF-α, IL-6, IL-12/23 p40, and IL-1β and stimulated the phagocytosis of E. coli in a dose-dependent manner. This effect was independent of LPS as shown by the use of macrophages isolated from LPS-resistant C3H/HeJ mice. At concentrations up to 30 mg/l it was not toxic to bacteria or eukaryotic cells.

Conclusion

StroVac® does not only act via the adaptive but also by stimulating the innate immune system. This stimulation may help to build trained innate immunity against bacterial pathogens involved in recurrent urinary tract infections.
Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses
Authors: Nemirov Kirill , Authié Pierre , Souque Philippe , Moncoq Fanny , Noirat Amandine , Blanc Catherine , Bourgine Maryline , Majlessi Laleh , Charneau Pierre
Published: August 2023

Dengue virus (DENV) is responsible for approximately 100 million cases of dengue fever annually, including severe forms such as hemorrhagic dengue and dengue shock syndrome. Despite intensive vaccine research and development spanning several decades, a universally accepted and approved vaccine against dengue fever has not yet been developed. The major challenge associated with the development of such a vaccine is that it should induce simultaneous and equal protection against the four DENV serotypes, because past infection with one serotype may greatly increase the severity of secondary infection with a distinct serotype, a phenomenon known as antibody-dependent enhancement (ADE). Using a lentiviral vector platform that is particularly suitable for the induction of cellular immune responses, we designed a tetravalent T-cell vaccine candidate against DENV (“LV-DEN”). This vaccine candidate has a strong CD8+ T-cell immunogenicity against the targeted non-structural DENV proteins, without inducing antibody response against surface antigens. Evaluation of its protective potential in the preclinical flavivirus infection model, i.e., mice knockout for the receptor to the type I IFN, demonstrated its significant protective effect against four distinct DENV serotypes, based on reduced weight loss, viremia, and viral loads in peripheral organs of the challenged mice. These results provide proof of concept for the use of lentiviral vectors for the development of efficient polyvalent T-cell vaccine candidates against all DENV serotypes.
Treatment of posterior Benign Paroxysmal Positional Vertigo is efficient and safe with a new Mechanical Rotational Chair
Authors: Hougaard Dan Dupont , Duch Kirsten , Bech Mathias Winther
Published: August 2023

Background

Benign paroxysmal positional vertigo (BPPV) is the most predominant vestibular disease. Previously, in the management of BPPV, both therapeutic and diagnostic benefits with mechanical rotation chairs (MRCs) have been reported. However, no previous studies have examined the efficacy of MRC treatment with a fairly new MRC.

Methods

Randomized three-armed parallel open-labeled prospective clinical trial. One hundred and five patients diagnosed with posterior BPPV underwent diagnostics and treatment with an MRC. Patients were randomized to either a Semont maneuver, an Epley maneuver or a 360-degree backwards somersault maneuver. Primary endpoint was to evaluate the efficiency of an MRC in the treatment of posterior BPPV with three separate treatment modalities. Secondary objectives included subjective vertigo assessments.

Results

BPPV treatment with this MRC is very efficient with success rates up to 97.1 percent. The number of treatments required to achieve complete resolution of both objective findings and subjective symptoms was 1.5. Almost 47 percent of patients experienced complete resolution of both subjective and objective measures following one (first) treatment. All Dizziness Handicap Inventory scores decreased significantly post-treatment.

Conclusion

Treatment of posterior BPPV, with the MRC used in this study, was very efficient with both the Semont, the Epley, and the 360-degree backwards somersault maneuver. Based on the findings in this study, this fairly new MRC seems both effective and safe to use.
A nomogram-based optimized Radscore for preoperative prediction of lymph node metastasis in patients with cervical cancer after neoadjuvant chemotherapy
Authors: Ai Conghui , Zhang Lan , Ding Wei , Zhong Suixing , Li Zhenhui , Li Miaomiao , Zhang Huimei , Zhang Lan , Zhang Lei , Hu Hongyan
Published: August 2023

Purpose

To construct a superior single-sequence radiomics signature to assess lymphatic metastasis in patients with cervical cancer after neoadjuvant chemotherapy (NACT).

Methods

The first half of the study was retrospectively conducted in our hospital between October 2012 and December 2021. Based on the history of NACT before surgery, all pathologies were divided into the NACT and surgery groups. The incidence rate of lymphatic metastasis in the two groups was determined based on the results of pathological examination following lymphadenectomy. Patients from the primary and secondary centers who received NACT were enrolled for radiomics analysis in the second half of the study. The patient cohorts from the primary center were randomly divided into training and test cohorts at a ratio of 7:3. All patients underwent magnetic resonance imaging after NACT. Segmentation was performed on T1-weighted imaging (T1WI), T2-weighted imaging, contrast-enhanced T1WI (CET1WI), and diffusion-weighted imaging.

Results

The rate of lymphatic metastasis in the NACT group (33.2%) was significantly lower than that in the surgery group (58.7%, P=0.007). The area under the receiver operating characteristic curve values of Radscore_CET1WI for predicting lymph node metastasis and non-lymphatic metastasis were 0.800 and 0.797 in the training and test cohorts, respectively, exhibiting superior diagnostic performance. After combining the clinical variables, the tumor diameter on magnetic resonance imaging was incorporated into the Rad_clin model constructed using Radscore_CET1WI. The Hosmer–Lemeshow test of the Rad_clin model revealed no significant differences in the goodness of fit in the training (P=0.594) or test cohort (P=0.748).

Conclusions

The Radscore provided by CET1WI may achieve a higher diagnostic performance in predicting lymph node metastasis. Superior performance was observed with the Rad_clin model.
Case Report: A MiT family translocation renal cell carcinoma in the renal pelvis, calyces and upper ureter misdiagnosed as upper tract urothelial carcinoma
Authors: Zou Yuhua , Liu Linwei , Xie Xiaojuan , Zhong Cunzhi , Wang Qinlin , Yan Sheng , Liu Quanliang
Published: August 2023

Background

Upper tract urothelial carcinoma (UTUC) is the most common urothelial malignancy in the renal pelvis or ureter. Renal pelvic carcinoma accounts for 90% of all tumours in the renal pelvis, so the mass in the renal pelvis is usually considered a UTUC. Renal cell carcinoma (RCC) in the renal pelvis, calyces and upper ureter is extremely rare, especially MiT family translocation RCC, which makes this case even more uncommon.

Case presentation

We report the case of a 54-year-old man had intermittent painless gross haematuria with occasional blood clots and urodynia for 2 years. Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) scan showed an enlarged left kidney, and a soft tissue mass was seen in the renal pelvis, calyces and upper ureter. The patient’s urine-based cytology was positive three times. Due to the severity of the upper ureteral lumen stenosis, we did not perform pathological biopsy during ureteroscopy. In the current case, clinical symptoms, imaging examinations, urine-based cytology, and ureteroscopy were combined to obtain a preoperative diagnosis of UTUC. Therefore, robot-assisted laparoscopic left radical nephroureterectomy and retroperitoneal lymphadenectomy were performed. Unexpectedly, the patient was pathologically diagnosed with MiT family translocation RCC after surgery. The surgery was uneventful. There was no intestinal tube injury or other complications perioperatively. The postoperative follow-up was satisfactory.

Conclusion

MiT family translocation RCC in the renal pelvis, calyces and upper ureter is extremely rare, and can be easily confused with UTUC, resulting in the expansion of surgical scope. Preoperative ureteroscopy and biopsy or tumour punch biopsy should be used to obtain accurate pathology as far as possible, and the selection of correct surgical method is conducive to a good prognosis for patients.
Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging
Authors: López-González Elga , García-Jiménez Rocío , Rodríguez-Jiménez Alberto , Rojas-Luna José Antonio , Daza-Manzano Cinta , Gómez-Salgado Juan , Álvarez Rosa María
Published: August 2023

Objective

To evaluate whether the introduction of tumor volume as new parameter in the MRI assessment could improve both concordance between preoperative and postoperative staging, and the identification of histological findings.

Methods

A retrospective observational study with 127 patients with endometrial cancer (EC) identified between 2016 and 2021 at the Juan Ramon Jimenez University Hospital, Huelva (Spain) was carried out. Tumor volume was measured in three ways. Analyses of Receiver Operating Characteristic (ROC) curve and the area under the curve (AUC) were performed.

Results

Although preoperative MRI had an 89.6% and 66.7% sensitivity for the detection of deep mucosal invasion and cervical stroma infiltration, preoperative assessment had an intraclass correlation coefficient of 0.517, underestimating tumor final stage in 12.6% of cases, with a poor agreement between preoperative MRI and postoperative staging (κ=0.082) and low sensitivity (14.3%) for serosa infiltration. The cut-off values for all three volume parameters had good/excellent AUC (0.73-0.85), with high sensitivity (70-83%) and specificity (64-84%) values for all histopathological variables. Excellent/good agreement was found all volume parameters for the identification of deep myometrial invasion (0.71), cervical stroma infiltration (0.80), serosa infiltration (0.81), and lymph node metastases (0.81).

Conclusion

Tumor volume measurements have good predictive capacity to detect histopathological findings that affect final tumor staging and might play a crucial role in the preoperative assessment of patients with endometrial cancer in the future.
Neuroprotective effect of dexmedetomidine on autophagy in mice administered intracerebroventricular injections of Aβ25–35
Authors: Lee Youn Young , Han Jong In , Lee Kyung Eun , Cho Sooyoung , Suh Eun Cheng
Published: August 2023

Alzheimer’s disease (AD), one of the most prevalent neurodegenerative diseases is associated with pathological autophagy-lysosomal pathway dysfunction. Dexmedetomidine (Dex) has been suggested as an adjuvant to general anesthesia with advantages in reducing the incidence of postoperative cognitive dysfunction in Dex-treated patients with AD and older individuals. Several studies reported that Dex improved memory; however, evidence on the effects of Dex on neuronal autophagy dysfunction in the AD model is lacking. We hypothesized that Dex administration would have neuroprotective effects by improving pathological autophagy dysfunction in mice that received an intracerebroventricular (i.c.v.) injection of amyloid β-protein fragment 25–35 (Aβ25–35) and in an autophagy-deficient cellular model. In the Y-maze test, Dex reversed the decreased activity of Aβ25–35 mice. Additionally, it restored the levels of two memory-related proteins, phosphorylated Ca2+/calmodulin-dependent protein kinase II (p-CaMKII) and postsynaptic density-95 (PSD-95) in Aβ25–35 mice and organotypic hippocampal slice culture (OHSC) with Aβ25–35. Dex administration also resulted in decreased expression of the autophagy-related microtubule-associated proteins light chain 3-II (LC3-II), p62, lysosome-associated membrane protein2 (LAMP2), and cathepsin D in Aβ25–35 mice and OHSC with Aβ25–35. Increased numbers of co-localized puncta of LC3-LAMP2 or LC3-cathepsin D, along with dissociated LC3-p62 immunoreactivity following Dex treatment, were observed. These findings were consistent with the results of western blots and the transformation of double-membrane autophagosomes into single-membraned autolysosomes in ultrastructures. It was evident that Dex treatment alleviated impaired autolysosome formation in Aβ mice. Our study demonstrated the improvement of memory impairment caused by Dex and its neuroprotective mechanism by investigating the role of the autophagy-lysosomal pathway in a murine Aβ25–35 model. These findings suggest that Dex could be used as a potential neuroprotective adjuvant in general anesthesia to prevent cognitive decline.
Lead perovskites as CEνNS detectors
Authors: Jesús-Valls César , Sánchez Federico
Published: August 2023

Introduction: The recent discovery of coherent elastic neutrino-nucleus scattering (CEvNS) has created new opportunities to detect and study neutrinos. The interaction cross section in CEvNS scales quadratically with the number of neutrons, making heavy-nuclei targets such as active lead-based detectors ideal. Lead perovskites have emerged in the last decade as revolutionary materials for radiation detection due to their heavy and flexible element composition and their unique optoelectronic properties that result in an excellent energy resolution at an economic cost.

Methodology: In this study, we discuss, for the first time, the physics potential and feasibility of building neutrino detectors using semiconductor lead perovskite crystals as a target.

Results and Discussion: We indicate that existing data with x-rays suggest the suitability of existing lead perovskite sensors to study CEvNS using neutrinos from π decay at rest (π- DAR) sources. Although dedicated research and development will be necessary, we have found significant benefits and no inherent obstacles for the development of lead perovskites as CEvNS detectors.