bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiation impacts gene redundancy and biofilm regulation of cryoconite microbiomes in Northern Hemisphere glaciers
Authors: Zhang Zhihao , Liu Yongqin , Zhao Weishu , Ji Mukan
Published: October 2023

Background

Glaciers harbor diverse microorganisms adapted to extreme conditions with high radiation, fluctuating temperature, and low nutrient availability. In glacial ecosystems, cryoconite granules are hotspots of microbial metabolic activity and could influences the biogeochemical cycle on glacier surface. Climate change could influence glacier dynamics by changing regional meteorological factors (e.g., radiation, precipitation, temperature, wind, and evaporation). Moreover, meteorological factors not only influence glacier dynamics but also directly or indirectly influence cryoconite microbiomes. However, the relationship of the meteorological factors and cryoconite microbiome are poorly understood.

Results

Here, we collected 88 metagenomes from 26 glaciers distributed in the Northern Hemisphere with corresponding public meteorological data to reveal the relationship between meteorological factors and variation of cryoconite microbiome. Our results showed significant differences in taxonomic and genomic characteristics between cryoconite generalists and specialists. Additionally, we found that the biogeography of both generalists and specialists was influenced by solar radiation. Specialists with smaller genome size and lower gene redundancy were more abundant under high radiation stress, implying that streamlined genomes are more adapted to high radiation conditions. Network analysis revealed that biofilm regulation is a ubiquitous function in response to radiation stress, and hub genes were associated with the formation and dispersion of biofilms.

Conclusion

These findings enhance our understanding of glacier cryoconite microbiome variation on a hemispheric scale and indicate the response mechanisms to radiation stress, which will support forecasts of the ecological consequences of future climate change.
The relationship between cannabis and anorexia nervosa: a scoping review
Authors: Rogers Chloe I. , Pacanowski Carly R.
Published: October 2023

Background

Relapse rates in Anorexia Nervosa (AN) remain high, warranting exploration of further treatments. Cannabinoid agonists are of interest as they have shown successful outcomes in the treatment of associated conditions, such as post-traumatic stress disorder. This scoping review explores the endocannabinoid system (ECS), benefits/harms/null effects of cannabinoid treatment, and harms of cannabis use in AN.

Methods

PubMed, PsycINFO, Cochrane, and Web of Science were searched for studies published between 2010 and August 2023, with human participants that explored the ECS, cannabinoid treatment, or cannabis use, and included 1 or more keywords for both cannabis and AN in the title and or abstract. Reports describing secondary anorexia, reports not available in English, grey literature, reports combining data from AN with other conditions, and reports only reporting the prevalence of cannabis abuse/dependence were excluded. Data were extracted from 17 reports (n = 15 studies). For the ECS, outcomes included genetics such as allele expression related to the ECS, cannabinoid receptor availability, and circulating levels of endocannabinoids. For benefits/harms/null effects of cannabinoid treatment, outcomes included changes in weight, eating disorder (ED) symptoms, physical activity (PA), and hormones. For harms of cannabis use, outcomes included genetics related to cannabis use disorder and associations between cannabis use and ED symptoms.

Results

Eight studies (n = 8 reports) found abnormalities in the ECS in AN including expression of related alleles, genotypes, and haplotypes, availability of cannabinoid receptors, and levels of endocannabinoids. Three studies (n = 5 reports) found benefits/harms/null effects of cannabinoid treatment. Benefits included weight gain, improved ED symptoms and reduced PA, while null effects included no changes in weight or ED symptoms, and harms included increased PA and lowered adipose hormones. Four studies (n = 4 reports) expanded upon harms of cannabis use, including genetic predispositions to cannabis use disorder, and compensatory behaviors related to cannabis use.

Conclusion

Limited evidence suggests that abnormalities in the ECS in AN may render cannabis a potential treatment for weight restoration and associated symptoms. Future research may wish to investigate individualized dosing approaches to maximize beneficial effects while minimizing harms.

Level II Evidence: Scoping Review.
Relationship between career maturity, psychological separation, and occupational self-efficacy of postgraduates: moderating effect of registered residence type
Authors: Ni Jianchao , Zhang Jiawen , Wang Yumei , Li Dongchen , Chen Chunmei
Published: October 2023

Background

With the slowdown of economic growth and the increasing pressure of employment competition worldwide during the normalized epidemic prevention and control, the job-hunting intention and behavior of college graduates deserve in-depth study. This study explores the relationship between the career maturity, psychological separation and occupational self-efficacy of postgraduates, and provides a theoretical basis for improving their career maturity.

Methods

A questionnaire survey was carried out on postgraduates with 584 valid data in China by using the Career Maturity Scale, Psychological Separation Scale and the Occupational Self-efficacy Scale. A structural equation model and bias-corrected self-sampling method were adopted to explore their relationship. The moderating effect of registered residence type was tested.

Results

The results show that: (1) The higher the level of psychological separation of postgraduates, the higher their career maturity. (2) Occupational self-efficacy plays a mediating role in the process of psychological separation promoting career maturity. (3) The registered residence type moderates the latter half of the mediating process of psychological separation, occupational self-efficacy, and career maturity. Moreover, occupational self-efficacy plays a more significant role in promoting the career maturity of postgraduates with rural registered residence.

Conclusions

This study reveals the relationship between the career maturity, psychological separation and occupational self-efficacy of postgraduates. At the same time, it also verifies the mediating role of occupational self-efficacy and the moderating role of registered residence type. The result is helpful for postgraduates to understand the level of their career maturity and improve their career decision-making level and career development ability.
Validation of the Chinese version of the Rosenberg Self-Esteem Scale: evidence from a three-wave longitudinal study
Authors: Jiang Chen , Zhu Yihong , Luo Yi , Tan Chee-Seng , Mastrotheodoros Stefanos , Costa Patrício , Chen Li , Guo Lina , Ma Haiyan , Meng Runtang
Published: October 2023

Background

The 10-item Rosenberg Self-Esteem Scale (RSES) is a widely used tool for individuals to self-report their self-esteem; however, the factorial structures of translated versions of the RSES vary across different languages. This study aimed to validate the Chinese version of the RSES in the Chinese mainland using a longitudinal design.

Methods

A group of healthcare university students completed the RSES across three waves: baseline, 1-week follow-up, and 15-week follow-up. A total of 481 valid responses were collected through the three-wave data collection process. Exploratory factor analysis (EFA) was performed on the baseline data to explore the potential factorial structure, while confirmatory factor analysis (CFA) was performed on the follow-up data to determine the best-fit model. Additionally, the cross-sectional and longitudinal measurement invariances were tested to assess the measurement properties of the RSES for different groups, such as gender and age, as well as across different time points. Convergent validity was assessed against the Self-Rated Health Questionnaire (SRHQ) using Spearman’s correlation. Internal consistency was examined using Cronbach’s alpha and McDonald’s omega coefficients, while test–retest reliability was assessed using intraclass correlation coefficient.

Results

The results of EFA revealed that Items 5, 8, and 9 had inadequate or cross-factor loadings, leading to their removal from further analysis. Analysis of the remaining seven items using EFA suggested a two-factor solution. A comparison of several potential models for the 10-item and 7-item RSES using CFA showed a preference for the 7-item form (RSES-7) with two factors. Furthermore, the RSES-7 exhibited strict invariance across different groups and time points, indicating its stability and consistency. The RSES-7 also demonstrated adequate convergent validity, internal consistency, and test–retest reliability, which further supported its robustness as a measure of self-esteem.

Conclusions

The findings suggest that the RSES-7 is a psychometrically sound and brief self-report scale for measuring self-esteem in the Chinese context. More studies are warranted to further verify its usability.
Evaluation of stability and functionality of zinc oxide nanofluids for enhanced oil recovery
Authors: Tuok Lengu Peter , Elkady Marwa , Zkria Abdelrahman , Yoshitake Tsuyoshi , Nour Eldemerdash Usama
Published: October 2023

Nanofluids for enhanced oil recovery offer a breakthrough solution towards tertiary recovery and consequently higher oil production. Their ability to reduce interfacial tension, alteration of formation’s wettability, higher adsorption capacity, and acceleration of disjoining pressure makes them excellent candidates for enhanced oil recovery. The main objective of this paper is to investigate the effect of polymers on zinc oxide (ZnO) nanofluids for enhanced oil recovery (EOR) and the role played by chemical modification using polymer stabilizers on nanoparticle stability in nanofluids. Nanoparticles with an average particle size of 34 nm were synthesized and used to prepare nanofluids of different concentrations and their stability was evaluated using sedimentation and UV–vis spectrophotometry tests. ZnO-synthesized nanofluids were used solely and in addition to Polyvinylpyrrolidone (PVP) and Polyvinyl alcohol (PVA) as stabilizing agents. It was noted that ZnO nanofluids with PVA stabilizer recorded the highest oil recovery of 82%. In contrast, the ZnO nanofluids without stabilizing agents registered the lowest recovery rate during the flooding experiment. The results revealed that a higher injection rate increases the oil recovery and reduces the viscous fingering effect with a better displacement front. Furthermore, nanofluids containing polymeric stabilizing agents achieved better recovery factors compared to ZnO nanofluids without stabilizing agents. This phenomenon was also observed in the interfacial tension test where nanofluids with PVA and PVP stabilizers reduced the IFT by 59% and 61% respectively.
Construction and application of a knowledge graph-based question answering system for Nanjing Yunjin digital resources
Authors: Xu Liang , Lu Lu , Liu Minglu
Published: October 2023

Nanjing Yunjin, one of China's traditional silk weaving techniques, is renowned for its unique local characteristics and exquisite craftsmanship, and was included in the Representative List of the Intangible Cultural Heritage of Humanity by UNESCO in 2009. However, with rapid development in weaving technology, ever-changing market demands, and shifting public aesthetics, Nanjing Yunjin, as an intangible cultural heritage, faces the challenge of survival and inheritance. Addressing this issue requires efficient storage, management, and utilization of Yunjin knowledge to enhance public understanding and recognition of Yunjin culture. In this study, we have constructed an intelligent question-answering system for Nanjing Yunjin digital resources based on knowledge graph, utilizing the Neo4j graph database for efficient organization, storage, and protection of Nanjing Yunjin knowledge, thereby revealing its profound cultural connotations. Furthermore, we adopted deep learning algorithms for natural language parsing. Specifically, we adopted BERT-based intent recognition technology to categorize user queries by intent, and we employed the BERT + BiGRU + CRF model for entity recognition. By comparing with BERT + BILSTM + CRF, BERT + CRF and BILSTM + CRF models, our model demonstrated superior performance in terms of precision, recall, and F1 score, substantiating the superiority and effectiveness of this model. Finally, based on the parsed results of the question, we constructed knowledge graph query statements, executed by the Cypher language, and the processed query results were fed back to the users in natural language. Through system implementation and testing, multiple indices including system response time, stability, load condition, accuracy, and scalability were evaluated. The experimental results indicated that the Nanjing Yunjin intelligent question-answering system, built on the knowledge graph, is able to efficiently and accurately generate answers to user’s natural language queries, greatly facilitating the retrieval and utilization of Yunjin knowledge. This not only reinforces the transmission, promotion, and application of Yunjin culture but also provides a paradigm for constructing other intangible cultural heritage question-answering systems based on knowledge graphs. This has substantial theoretical and practical significance for deeply exploring and uncovering the knowledge structure of human intangible heritage, promoting cultural inheritance and protection.
Tectonic significance of the 2021 Lamjung, Nepal, mid-crustal seismic cluster
Authors: Koirala Bharat Prasad , Laporte Marine , Bollinger Laurent , Batteux Daria , Letort Jean , Guilhem Trilla Aurélie , Wendling-Vazquez Nicolas , Bhattarai Mukunda , Subedi Shiba , Adhikari Lok Bijaya
Published: October 2023

Since the Mw 7.9 Gorkha earthquake of April 25, 2015, the seismicity of central and western Nepalese Himalaya has been monitored by an increasing number of permanent seismic stations. These instruments contribute to the location of thousands of aftershocks that occur at the western margin of the segment of the Main Himalayan Thrust (MHT) that ruptured in 2015. They also help to constrain the location of seismic clusters that originated at the periphery of the fault ruptured by the Gorkha earthquake, which may indicate a migration of seismicity along the fault system. We report here a seismic crisis that followed the Lamjung earthquake, a moderate Mw 4.7 event (ML 5.8, MLv 5.3) that occurred on May 18, 2021, about 30 km west of the Gorkha earthquake epicenter at the down-dip end of the locked fault zone. The study of the hypocentral location of the mainshock and its first 117 aftershocks confirms mid-crustal depths and supports the activation of a 30–40° dipping fault plane, possibly associated with the rupture of the updip end of the MHT mid-crustal ramp. The cluster of aftershocks occurs near the upper decollement of the thrust system, probably in its hanging wall, and falls on the immediate northern margin of a region of the fault that has not been ruptured since the 1344 or 1505 CE earthquake. The spatio-temporal distribution of the first 117 aftershocks shows a typical decrease in the associated seismicity rate and possible migration of seismic activity. Since then, the local seismicity has returned to the pre-earthquake rate and careful monitoring has not revealed any large-scale migration of seismicity towards the locked fault segments.

Graphical Abstract
Report on the international workshop on seismic design and assessment for resilience, robustness and sustainability of slope engineering, 13–15 January 2023, Shanghai, China
Authors: Huang Yu , Mao Wuwei , Xiong Min , Wang Yian , Zhao Cuizhu , He Zhengying , Wang Fawu
Published: October 2023

The International Workshop on Seismic Design and Assessment for Resilience, Robustness and Sustainability of Slope Engineering was held on 13–15 January 2023 on line, focusing on the theme of “Seismic resilience of slope engineering and the concept of resilience-based seismic design (RBSD) for geological disaster prevention and control”. In this workshop, a number of keynote and invited lectures provided an international exchange platform for researchers, industrial engineers and students to share their research, engineering practice and exchange novel ideas on seismic resilience for slope engineering in a way of online. At the same time, during this workshop, technical committee of the ICGdR-TC1 also took this opportunity to hold a working meeting on cutting-edge and strategic issues, and released the Shanghai Declaration on slope engineering.
TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies
Authors: Leenhardt Julien , Biguet Petit Jean Alexandre , Raes Florian , N’Guessan Emilien , Debiossat Marlène , André Clémence , Bacot Sandrine , Ahmadi Mitra , de Leiris Nicolas , Djaileb Loïc , Ghezzi Catherine , Brunet Marie-Dominique , Broisat Alexis , Perret Pascale , du Moulinet d’Hardemare Amaury
Published: October 2023

Background

Despite the development of positron emission tomography (PET), single photon emission computed tomography (SPECT) still accounts for around 80% of all examinations performed in nuclear medicine departments. The search for new radiotracers or chelating agents for Technetium-99m is therefore still ongoing. O-TRENSOX and O-TRENOX two synthetic siderophores would be good candidates for this purpose as they are hexadentate ligands based on the very versatile and efficient 8-hydroxyquinoline chelating subunit. First, the radiolabeling of O-TRENOX and O-TRENSOX with 99mTc was investigated. Different parameters such as the quantity of chelating agent, type of reducing agent, pH and temperature of the reaction mixture were adjusted in order to find the best radiolabeling conditions. Then an assessment of the partition coefficient by measuring the distribution of each radiosynthesized complex between octanol and phosphate-buffered saline was realized. The complex’s charge was evaluated on three different celluloses (neutral, negatively charged P81 and positively charged DE81), and finally in vivo studies with biodistribution and SPECT imaging of [99mTc]Tc-O-TRENOX and [99mTc]Tc-O-TRENSOX were performed.

Results

The radiolabeling studies showed a rapid and efficient complexation of 99mTc with both chelating agents. Using tin pyrophosphate as the reducing agent and a minimum of 100 nmol of ligand, we obtained the [99mTc]Tc-O-TRENOX complex with a radiochemical purity of more than 98% and the [99mTc]Tc-O-TRENSOX complex with one above 97% at room temperature within 5 min. [99mTc]Tc-O-TRENOX complex was lipophilic and neutral, leading to a hepatobiliary elimination in mice. On the contrary, the [99mTc]Tc-O-TRENSOX complex was found to be hydrophilic and negatively charged. This was confirmed by a predominantly renal elimination in mice.

Conclusions

These encouraging results allow us to consider the O-TRENOX/99mTc and O-TRENSOX/99mTc complexes as serious candidates for SPECT imaging chelators. This study should be continued by conjugating these tris-oxine ligands to peptides or antibodies and comparing them with the other bifunctional agents used with Tc.
Belt and road initiative and healthy silk road: an alternative path for Pacific island countries to participate in global public health governance
Authors: Mei Yujie
Published: October 2023

Pacific island countries (PICs) located in a region with relatively insufficient capacity to respond to public health emergencies, establishing reliable public health cooperation is conducive to maintaining security and stability. The belt and road initiative (BRI) launched by China attempts to provide a novel form of international cooperation and has supported multi-channel investment and construction. This article elucidates the history of public health cooperation between China and PICs, as well as the current situation of the BRI in the field of public health and emphasizes that there are numerous constraints in the public health cooperation between China and PICs. Given the profound impact of COVID-19 on diplomatic strategies, gradual cooperation in the field of public health may be the initial exploration of the BRI in the PICs, but it also means that the initiative must deal with challenges from geopolitical competition and cultural differences.
Schema matching based on energy domain pre-trained language model
Authors: Pan Zhiyu , Yang Muchen , Monti Antonello
Published: October 2023

Data integration in the energy sector, which refers to the process of combining and harmonizing data from multiple heterogeneous sources, is becoming increasingly difficult due to the growing volume of heterogeneous data. Schema matching plays a crucial role in this process by giving each representation a unique identity by matching raw energy data to a generic data model. This study uses an energy domain language model to automate schema matching, reducing manual effort in integrating heterogeneous data. We developed two energy domain language models, Energy BERT and Energy Sentence Bert, and trained them using an open-source scientific corpus. The comparison of the developed models with the baseline model using real-life energy domain data shows that Energy BERT and Energy Sentence Bert models significantly improve the accuracy of schema matching.
Finding individual strategies for storage units in electricity market models using deep reinforcement learning
Authors: Harder Nick , Weidlich Anke , Staudt Philipp
Published: October 2023

Modeling energy storage units realistically is challenging as their decision-making is not governed by a marginal cost pricing strategy but relies on expected electricity prices. Existing electricity market models often use centralized rule-based bidding or global optimization approaches, which may not accurately capture the competitive behavior of market participants. To address this issue, we present a novel method using multi-agent deep reinforcement learning to model individual strategies in electricity market models. We demonstrate the practical applicability of our approach using a detailed model of the German wholesale electricity market with a complete fleet of pumped hydro energy storage units represented as learning agents. We compare the results to widely used modeling approaches and demonstrate that the proposed method performs well and can accurately represent the competitive behavior of market participants. To understand the benefits of using reinforcement learning, we analyze overall profits, aggregated dispatch, and individual behavior of energy storage units. The proposed method can improve the accuracy and realism of electricity market modeling and help policymakers make informed decisions for future market designs and policies.
Cannabinoid hyperemesis syndrome presenting with ventricular bigeminy
Authors: Wong Jeffrey , Gill Muneet , Stead Thor , Huang Derrick , Ganti Latha
Published: October 2023

The is a case of a 28-year-old male presenting to an emergency department (ED) via emergency medical services (EMS) with a chief complaint of “gastritis.” He was noted to have bigeminy on the pre-arrival EMS electrocardiogram. He was ultimately diagnosed with cannabinoid hyperemesis syndrome (CHS). CHS is becoming an exceedingly common emergency department presentation due to the poorly regulated but widespread availability of cannabis products. The authors discuss a case of CHS and ventricular bigeminy.
Integrative bioinformatics analysis of miRNA and mRNA expression profiles identified some potential biomarkers for breast cancer
Authors: Rezaeijo Seyed Masoud , Rezaei Monireh , Poursheikhani Arash , Mohammadkhani Shima , Goharifar Naieme , Shayankia Ghazal , Heydarheydari Sahel , Saberi Alihossein , Taghizadeh Eskandar
Published: October 2023

Background

Breast cancer is a common cause of cancer death among women with a complex and heterogeneous picture in histological, molecular and clinical features. The aim of this study was to identify hub gene and their target microRNAs in related pathways for breast cancer.

Methods

We selected screening methods for differentially expressed mRNAs and miRNAs using expression profile data of breast cancer from the cancer genome atlas. Using some databases for annotation, the functional and pathway enrichment for differential expression genes was performed. We selected genes and miRNAs with differential expression pattern. Then we determined target genes for differential expression miRNAs (DEMIs) and intersection between them was selected as differentially expressed miRNA–target genes for breast cancer. In the next step, we constructed miRNA–mRNA regulatory network and protein–protein interaction (PPI) network for more information.

Results

Top 10 DEMIs were identified from miRNA profile. Then, we selected 354 genes as target gene for 10 DEMIs. The miRNA–mRNA and PPI network were constructed, and 10 hub genes and 5 miRNAs identified that some of them are new for breast cancer. Also, miRNA–target genes with differential expressions in this study were all mainly involved in signaling pathways and developmental process.

Conclusion

This study identified some candidate biomarkers for breast cancer that they have a potential role in pathways related to breast. These findings can be used for research, early diagnosis and therapeutic goals.
Prevalence of sleep disturbances and its relationship with mobile phone overuse among an Iranian sample of students: a necessity for attention
Authors: Elahi Fatemeh , Mojahedi Mahya , Salehiniya Hamid , Raeisoon Mohammad Reza
Published: October 2023

Background and objectives

Sleep disturbances are recognized as a potential core feature of some major psychiatric conditions, and overuse of mobile phones in recent years can leave potential negative effects on this central feature, which is especially important to assess among students. Our study aimed to investigate the prevalence of sleep disturbances and its relationship with mobile phone overuse among an Iranian sample of university students.

Methods

After 406 Iranian students from the Birjand University of Medical Sciences completed the demographic data, Mobile Phone Problematic Use Scale (MPPUS), and Pittsburgh Sleep Quality Index (PSQI) questionnaires, data were analyzed using independent t-test, analysis of variance, and Pearson correlation coefficient.

Results

74.4% of individuals had a moderate to severe problem with their subjective sleep quality, and 33.7% had moderate to severe problems with delay in falling asleep. Additionally, 44.1% of individuals experienced mild to moderate problems in sleep duration, and most of them (97.3%) severely suffered from inadequate sleep efficiency. In terms of sleep disorders, 78.8% of individuals reported a mild problem. Furthermore, most individuals (81.3%) have not used sleep-inducing medications to fall asleep, and in terms of daily dysfunction, 75.57% individuals had mild to moderate problems. Additionally, a significant positive correlation of 0.244 was observed between the score of sleep disturbances and mobile phone overuse (P < 0.05).

Conclusions

The prevalence of sleep disturbances was quite considerable, and there was a significant positive relationship between excessive mobile phone use and sleep disturbances among the target group.
Assessing readiness to implement long-acting injectable HIV antiretroviral therapy: provider and staff perspectives
Authors: Koester Kimberly A. , Colasanti Jonathan A. , McNulty Moira C. , Dance Kaylin , Erguera Xavier A. , Tsuzuki Manami Diaz , Johnson Mallory O. , Sauceda John A. , Montgomery Elizabeth , Schneider John , Christopoulos Katerina A.
Published: October 2023

Background

Long-acting injectable antiretroviral therapy (LAI-ART) represents the next innovation in HIV therapy. Pre-implementation research is needed to develop effective strategies to ensure equitable access to LAI-ART to individuals living with HIV.

Methods

We conducted focus group discussions (FGDs) with providers and staff affiliated with HIV clinics in San Francisco, Chicago, and Atlanta to understand barriers to and facilitators of LAI-ART implementation. Participants also completed a short survey about implementation intentions. FGDs were held via video conference, recorded, transcribed, and thematically analyzed using domains associated with the Consolidated Framework for Implementation Research (CFIR).

Results

Between September 2020 and April 2021, we led 10 FDGs with 49 participants, of whom ~60% were prescribing providers. Organizational readiness for implementing change was high, with 85% agreeing to being committed to figuring out how to implement LAI-ART. While responses were influenced by the unique inner and outer resources available in each setting, several common themes, including implementation mechanisms, dominated: (1) optimism and enthusiasm about LAI-ART was contingent on ensuring equitable access to LAI-ART; (2) LAI-ART shifts the primary responsibility of ART adherence from the patient to the clinic; and (3) existing clinic systems require strengthening to meet the needs of patients with adherence challenges. Current systems in all sites could support the use of LAI-ART in a limited number of stable patients. Scale-up and equitable use would be challenging or impossible without additional personnel. Participants outlined programmatic elements necessary to realize equitable access including centralized tracking of patients, capacity for in-depth, hands-on outreach, and mobile delivery of LAI-ART. Sites further specified unknown logistical impacts on implementation related to billing/payer source as well as shipping and drug storage.

Conclusions

Among these HIV care sites, clinic readiness to offer LAI-ART to a subset of patients is high. The main challenges to implementation include concerns about unequal access and a recognition that strengthening the clinic system is critical.
Dielectric materials development using bio-waste: a review
Authors: Zainol Norazwina , Mustafa Nurfarhana , Aziz Nor Hazwani , Azman Azahani Natasha , Abdul Karim Mohamad Shaiful
Published: October 2023

The increasing global demand for food due to population expansion has led to the intensification of the agricultural sector. However, this escalation in agricultural production has brought together undesirable consequences as more waste is produced, leading to growing environmental concerns as proper disposal of these wastes is necessary. Valorization of these bio-wastes into dielectric materials offers a promising solution to conventional, non-renewable, yet costly materials. Comprehensive documentation on the development of these wastes into dielectric materials is then necessary to understand their dielectric properties and how these materials behave with the treatments during the fabrication process. This review focuses on the state-of-the-art development of dielectric materials derived from bio-wastes and agricultural waste, which are beneficial for waste management and materials engineering applications. The elemental composition of the waste materials is also discussed in this review to understand its relationship with the dielectric constant. Moreover, the fabrication process for several waste materials into dielectric materials has been provided and compared. This review provides comprehensive information on green materials in the materials engineering industries and can assist in novel studies. It is foreseen that bio-wastes and agricultural wastes can be renewable, sustainable, and low-cost resources for deriving dielectric materials in light of their ease of accessibility.
A deep-learning framework for borehole formation properties prediction using heterogeneous well-logging data: A case study of a carbonate reservoir in the Gaoshiti-Moxi area, Sichuan Basin, China
Authors: Lin Lei , Huang Hong , Zhang Pengyun , Yan Weichao , Wei Hao , Liu Hang , Zhong Zhi
Published: October 2023

The properties of borehole formations, such as porosity, permeability, and water saturation, play a crucial role in characterizing and evaluating subsurface reservoirs. Although core sample experiments offer precise measurements, they are time consuming and cost intensive. An alternative method is to use the logging data to construct an empirical model that predicts formation properties, which is widely studied due to its speed and affordability. Nevertheless, because the response of a logging point reflects its surrounding formation, conventional logging methods relying on point-to-point (P2P) mapping perform poorly in complex reservoirs. Furthermore, the resolution of conventional logging is lower compared with imaging logging. To address these limitations, this study presents a novel approach to predict formation properties based on a deep-learning framework using heterogeneous well-logging data. Our neural network framework takes short sequences of conventional logging data and windowed imaging logging data as inputs. The neural network applies 1D convolution to extract features from the conventional logging sequences and 2D convolution to extract features from the resistivity imaging data. Then, these two feature vectors are fused and fed into a multilayer fully connected neural network to predict formation properties. A case study of a carbonate reservoir demonstrates that our method delivers more accurate predictions of formation porosity, permeability, and water saturation than the P2P, sequence-to-point, and image-to-point prediction methods. Moreover, it is expected that our paradigm will serve as a source of inspiration for forthcoming research endeavors aimed at enhancing the accuracy of predicting borehole formation properties in complex reservoirs.
Inflammatory Myofibroblastic Tumor With ROS1 Gene Fusions in Children and Young Adolescents
Authors: Schoot Reineke A. , Orbach Daniel , Minard Colin Veronique , Alaggio Rita , Di Carlo Daniela , Corradini Nadege , Mercolini Federico , Milano Giuseppe Maria , van Noesel Max M. , Rome Angelique , Dall’Igna Patrizia , Pajtler Kristian , Sparber-Sauer Monika , Ferrari Andrea , Casanova Michela
Published: October 2023

PURPOSE

Inflammatory myofibroblastic tumors (IMTs) are often driven by anaplastic lymphoma kinase fusions and less frequently by alternative fusions such as ROS1. We describe the clinical characteristics, treatment approach, and outcome for a series of young patients with IMTs and ROS1 alterations.

METHODS

This was a retrospective, international, multicenter study analyzing young patients (younger than 21 years) with ROS1-altered IMTs treated in 10 European referral centers between 2014 and 2022. Patients were included in the European pediatric Soft tissue sarcoma Study Group NRSTS-2005 protocol or registered in the Soft Tissue Sarcoma Registry. Primary surgery was recommended if a microscopic radical resection was feasible without mutilation. No standard systemic treatment protocol was available, but several medical options were recommended.

RESULTS

A total of 19 patients (median age 8.3 years) were included. Most patients had a biopsy at diagnosis (Intergroup Rhabdomyosarcoma Study [IRS] I; n = 2, IRS II; n = 1, IRS III biopsy; n = 11, IRS III resection; n = 3, IRS IV; n = 2). Twelve patients received neoadjuvant systemic therapy in first line (four received multiple treatments): high-dose steroids (n = 2), vinorelbine/vinblastine with methotrexate (n = 6), or ROS1 inhibitors (n = 8). After a median follow-up of 2.8 years (range, 0.2-13.4), seven patients developed an event. The 3-year event-free survival was 41% (95% CI, 11 to 71), and the 3-year overall survival was 100%.

CONCLUSION

Outcome for ROS1-altered IMTs appears excellent. A complete resection at diagnosis was often not feasible, and most patients needed neoadjuvant therapy. Patients who developed a tumor event could be cured with reinitiation of systemic therapy and/or surgery. This approach illustrates a switch in treatment philosophy moving from immediate, often mutilating, surgery to systemic (targeted) therapy as a bridge to more conservative surgery later in the treatment course.
Double-gradient seismic metamaterials with zero-frequency bandgap characteristic in a layered soil medium
Authors: Shi Nannan , Liu Han , Wang Lihui , Ji Jinbao , Li Zhenbao , Guo Shui , Wang Jian
Published: October 2023

Seismic metamaterials (SMs) are an artificially composite material designed within the sub-wavelength range. To attenuate low-frequency seismic surface waves, a metamaterial structural unit composed of a lead core and an auxetic foam coating layer was proposed; the higher impedance ratio results in the creation of a zero-frequency bandgap under layered soil conditions. To broaden the attenuation zone (AZ), double-gradient seismic metamaterials (DGSMs) were designed. The frequency domain analysis indicates that the attenuation area covering the range of 0–10 Hz is 89.8%. Through displacement-field analysis, the attenuation mechanism of DGSM on specific frequency surface waves can be fully explained. Finally, Taft seismic wave excitation is input for time history analysis, and the acceleration amplitude within 0–2 Hz decreases by 58.6%, which verifies the effectiveness of DGSMs in attenuation of low-frequency seismic waves.
LMS-Based Pediatric Reference Values for Parameters of Phosphate Homeostasis in the HARP Cohort
Authors: Pott Veronika , Tietze Helene , Kanzelmeyer Nele , von der Born Jeannine , Baumann Ulrich , Mindermann Charlotte , Suhlrie Adriana , Drube Jens , Melk Anette , Das Anibh M , Schnabel Dirk , Haffner Dieter , Leifheit-Nestler Maren
Published: October 2023

Context

The assessment of phosphate homeostasis in children is challenging due to the marked changes in laboratory parameters during growth and development, and the lack of adequate reference values.

Objective

To develop Lambda-Mu-Sigma (LMS)-based continuous pediatric reference percentiles for 7 key laboratory parameters of phosphate homeostasis.

Methods

This cross-sectional, single-center study, the HAnnover Reference values for Pediatrics (HARP) study, included 455 children aged 0.1-18 years (254 boys) from outpatient hospital clinics and a secondary school program. Main outcome measures were LMS-based continuous reference percentiles for serum phosphate, plasma intact fibroblast growth factor 23 (iFGF23), and its cofactor soluble Klotho (sKlotho), tubular maximum phosphate reabsorption per glomerular filtration rate (TmP/GFR), fractional tubular reabsorption of phosphate (TRP), and urinary calcium/creatinine (Ca/Crea) and phosphate/creatinine (Pi/Crea) ratios.

Results

LMS-based percentiles and z-scores were established for 7 key laboratory parameters of phosphate homeostasis, which were all found to be age-dependent. Serum phosphate, TmP/GFR, and sKlotho associated with sex. Serum phosphate, TmP/GFR, and urinary Ca/Crea and Pi/Crea levels were highest in infancy and declined until age 18 years, while phosphate and TmP/GFR values reached adult levels earlier in girls compared to boys. iFGF23 concentrations are highest in infancy and fall to a stable plateau by 4 years of age, while sKlotho peaks during adolescence.

Conclusion

This is the first report of LMS-based continuous pediatric reference percentiles for key laboratory parameters of phosphate homeostasis that allow calculation of standardized patient z-scores to facilitate test result interpretation in children and adolescents.
Associations Between Physical Activity and the Risk of Hip Fracture Depending on Glycemic Status: A Nationwide Cohort Study
Authors: Kim Kyoung Min , Kim Kyoung Jin , Han Kyungdo , Rhee Yumie
Published: October 2023

Context

Although physical activity (PA) is recognized to reduce fracture risk, whether its benefits differ according to glycemic status remains unknown.

Objective

We investigated the effect of PA on incident hip fracture (HF) according to glycemic status.

Methods

We studied 3 723 097 patients older than 50 without type 1 diabetes mellitus (DM) or past fractures. HF risks were calculated using Cox proportional hazard regression. Participants were categorized by glycemic status into 5 groups: normal glucose tolerance, impaired fasting glucose, new-onset type 2 DM, type 2 DM less than 5 years, and type 2 DM of 5 years or greater. PA was evaluated using the Korean adaptation of the International Physical Activity Questionnaire Short Form.

Results

The highest HF risk were associated with the lowest PA level (<500 metabolic equivalent task [MET]-min/wk). While similar risks emerged across MET 500 to 1000, 1000 to 1500, and greater than 1500 categories, the relationship showed variations in different glycemic status groups. Exceptions were particularly noted in women with normoglycemia. However, a consistent inverse pattern, with few exceptions, was observed both in men and women with type 2 DM of 5 years or greater. Furthermore, the benefit of PA in the prevention of HFs was most evident in participants with type 2 DM of 5 years or greater. Compared to the reference group (lowest physical activity level <500 MET-min/wk within type 2 DM ≥5 years), the adjusted hazard ratios were 0.74 (0.62-0.88) in men and 0.74 (0.62-0.89) in women, suggesting a significant reduction in risk.

Conclusion

Higher PA levels are associated with a lower risk of HF. This protective effect of PA on fracture risk is greatest in patients with DM, particularly in those with DM of 5 years or greater.
“There Are Lives Here”
Authors: McDowell Robin
Published: October 2023

The Bonnet Carré Spillway, a mile-long concrete and wood weir in St. Charles Parish, Louisiana, is embedded in a landscape of flood control infrastructure and an institutionally repressed history of the Black communities displaced for its construction from 1929 to 1931. Two cemeteries of enslaved and formerly enslaved people were plowed under and then resurfaced decades later, prompting a movement for commemoration led by descendants. Through histories of both the spillway structure and that of enslaved and formerly enslaved communities, this article examines a growing movement for commemoration that challenges and dismantles the political infrastructure generated by and for the preservation of physical infrastructure.
Developing Mixed-Effects Models to Compare the Predictive Ability of Various Comorbidity Indices in a Contemporary Cohort of Patients Undergoing Lumbar Fusion
Authors: Shahrestani Shane , Reardon Taylor , Brown Nolan J. , Kuo Cathleen C. , Gendreau Julian , Singh Rohin , Patel Neal A. , Chou Dean , Chan Andrew K.
Published: October 2023

BACKGROUND AND OBJECTIVE:

As incidence of operative spinal pathology continues to grow, so do the rates of lumbar spinal fusion procedures. Comorbidity indices can be used preoperatively to predict potential complications. However, there is a paucity of research defining the optimal comorbidity indices in patients undergoing spinal fusion surgery. We aimed to use modeling strategies to evaluate the predictive validity of various comorbidity indices and combinations thereof.

METHODS:

Patients who underwent spinal fusion were queried using data from the Nationwide Readmissions Database for the years 2016 through 2019. Using comorbidity indices as predictor variables, receiver operating characteristic curves were developed for pertinent complications such as mortality, nonroutine discharge, top-quartile cost, top-quartile length of stay, and 30-day readmission.

RESULTS:

A total of 750 183 patients were included. Nonroutine discharges occurred in 161 077 (21.5%) patients. The adjusted all-payer cost for the procedure was $37 616.97 ± $27 408.86 (top quartile: $45 409.20), and the length of stay was 4.1 ± 4.4 days (top quartile: 8.1 days). By comparing receiver operating characteristics of various models, it was found that models using Frailty + Elixhauser Comorbidity Index (ECI) as the primary predictor performed better than other models with statistically significant P-values on post hoc testing. However, for prediction of mortality, the model using Frailty + ECI was not better than the model using ECI alone (P = .23), and for prediction of all-payer cost, the ECI model outperformed the models using frailty alone (P < .0001) and the model using Frailty + ECI (P < .0001).

CONCLUSION:

This investigation is the first to use big data and modeling strategies to delineate the relative predictive utility of the ECI and Johns Hopkins Adjusted Clinical Groups comorbidity indices for the prognostication of patients undergoing lumbar fusion surgery. With the knowledge gained from our models, spine surgeons, payers, and hospitals may be able to identify vulnerable patients more effectively within their practice who may require a higher degree of resource utilization.
C1 Transposterior Arch Lateral Mass Screws Combined With C2 Pedicle Screw and Rod Fixation for Pediatric Atlantoaxial Subluxation: A Minimal 10-Year Follow-up Outcome Analysis
Authors: Zheng Gang , Yuan Bo , Zhao Yin , Guo Qunfeng , Li Fengning , Xu Zheng , Jia Lianshun , Chen Xiongsheng , Guo Xiang
Published: October 2023

BACKGROUND AND OBJECTIVES:

Although the short-term outcomes of the 1-step reduction and fixation technique using C1 transposterior arch lateral mass screws combined with C2 pedicle screw and rod fixation system for the treatment of pediatric atlantoaxial subluxation (AAS) have been satisfactory, its long-term outcomes and impact on spinal development are not well studied. This study was intended to assess the long-term reliability of this technique for pediatric AAS.

METHODS:

A retrospective case series study was conducted to analyze the minimum 10-year follow-up outcomes from 7 pediatric patients with AAS who underwent atlantoaxial fusion using the aforementioned technique. Quality of life and cervical range of motion were both measured thoroughly. In addition, vertical growth within the fusion construct (C1-2), overall cervical alignment, and subaxial cervical spine degeneration were evaluated radiographically.

RESULTS:

The mean age of the 7 patients was 8.14 ± 2.41 (6-12) years at the time of surgery. The mean follow-up period was 11.00 ± 1.15 (10-13) years. No patients presented identifiable intervertebral disk degeneration or segmental instability in the subaxial cervical spine except for 1 patient who showed mild intervertebral disk degeneration. Vertical growth did continue within the atlantoaxial complex after surgery (11.90% ± 2.37%); however, there was a decrease in the percentage of vertical growth compared with the corresponding normal populations of the same age and sex. Moreover, there was a significant decrease in the range of cervical extension and rotation motion, and the overall cervical alignment straightened at the latest follow-up.

CONCLUSION:

The 1-step reduction and fixation technique is a relatively reliable surgical technique for pediatric AAS, which does not adversely affect the postoperative quality of life or the subaxial cervical degeneration. Nevertheless, certain limitations, such as decreased cervical range of motion and changes in cervical alignment, should be concerned.