bluuebunny/crossref_metadata_2025 huggingface dataset:
Professional Training of Future Foreign Language Teachers: Socio-Cultural Aspect
Authors:   Candidate of Pedagogical Sciences, The teacher of English, Communal Higher Education Institution «Vinnytsia Humanities Pedagogical College», Kylyvnyk Victoria , Malyshevska Iryna ,   Doctor of Pedagogical Sciences, Professor of Special Education Department, Pavlo Tychyna Uman State Pedagogical University, Pavelkiv Kateryna ,   Candidate of Pedagogical Sciences, Docent, Associate Professor at the Department of Foreign Languages, Rivne State University of Humanities, Polishchuk Hanna ,   Assistant Professor, Assistant Professor of the English Language and Teaching Methods Department, Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, Hudovsek Oksana ,   Candidate of Pedagogical Sciences, Docent, Associate Professor at the Department of Primary Education Pedagogy, Rivne State University of Humanities, Zhuravska Nina ,   Doctor of Pedagogical Sciences, Professor of Management and Educational Technology Department, National University of Life and Environmental Sciences of Ukraine
Published: February 2022

The article examines socio-cultural aspect of professional training of future foreign language teachers. The purpose of the article is to substantiate the pedagogical conditions and structural and functional model of the socio-cultural competence formation of future foreign language teachers in the system of the pedagogical college. The main task of the study is to determine the structure, criteria, indicators and levels of socio-cultural competence of future foreign language teachers and to develop a structural and functional model of formation of their socio-cultural competence and its experimental verification. The research hypothesis lies in the assumption that the effectiveness of the socio-cultural competence of future foreign language teachers in the process of professional training in the pedagogical college will increase with the implementation of the following pedagogical conditions: the use of integrated socio-cultural tasks with variable content and innovative teaching methods. The formulated structural and functional model of sociocultural competence formation among future foreign language. The author's contribution to the development of the scientific field lies in the fact, that the use of interactive teaching methods encourages students to feel like subjects of socio-cultural competence and be active participants of this process. And this subjective position contributes to the development of cognitive motivation for socio-cultural competence, which contributes to the effective acquisition of socio-cultural knowledge and the effectiveness of the socio-cultural competence formation in general.
Formation of Professional Self-Determination of Future Teachers of Non-Language Specialties when Learning the English Language
Authors:   Candidate of Pedagogical Sciences, Associate Professor of the Department of Western and Eastern Languages and Methods of Their Teaching of the Faculty of Foreign Languages, South Ukrainian National Pedagogical University named after K. D. Ushinsky, Yemelyanova Daria , Tadeush Olga ,   Candidate of Physical and Mathematical Sciences, Associate Professor of the Department of Physics of the Physics and Mathematics Faculty, South Ukrainian National Pedagogical University named after K. D. Ushinsky, Dushechkina Nataliia ,   Candidate of Pedagogical Sciences, Associate Professor of the Department of Chemistry, Ecology and methods of their training, Pavlo Tychyna Uman State Pedagogical University, Masliuk Kateryna ,   Candidate of Pedagogical Sciences, associate professor of the Chair of Ukrainian language with teaching methods, Pavlo Tyhyna Uman State Pedagogical University, Malyshevskyi Oleh ,   Associate Professor at Vocational Education and Technologies on Profiles Department, Pavlo Tychyna Uman State Pedagogical University, Demchenko Iryna ,   Doctor of Pedagogical Sciences, Professor of the Department of Social Work and Rehabilitation, National University of Life and Environmental Sciences of Ukraine
Published: February 2022

The article reviews the formation of professional self-determination of future teachers of non-language specialties when learning the English language. The aim of the study was the formation of motivation for the study of the English language by students of pedagogical universities of non-linguistic specialties. The hypothesis of the research was that the use of the English language of the professional direction increases the motivation for learning the language, provides an awareness of the practical and theoretical significance of the knowledge gained for future professional activities and is a factor professional self-determination. Based on this goal, the following tasks were solved: studies of the professional orientation of students and the level of motivation for studying the discipline "English language of a professional direction" were carried out, measures were developed to form the professional self-determination of students. At the stage of the formative experiment, the work programs of the discipline are drawn up in such a way that each content module takes into account the urgent problems of the corresponding specialty. The use of modern information and innovative technologies in project activities contributed to the formation of professional motives for learning English, skills and abilities of communication in English in the professional sphere, an increase in the number of special terminology, the intensive development of all language skills: speaking, reading, listening and writing.
Word Reading Accuracy as a Mediator for Fluency
Authors:   ”Al. I. Cuza” Iași University, Romania, Tiron Katalin , Gherguț Alois ,   Ph.D, Associate Professor, ”Alexandru Ioan Cuza ” Iași University, Romania, Roșan Adrian Marian ,   Ph.D., Associate Professor, Babeș -Bolyai University, Cluj, Romania, Bostan Cristina Maria ,   Ph.D, postdoctoral researcher, ”Alexandru Ioan Cuza” University from Iași, Romania
Published: February 2022

This paper aims to test the predictive role of nonword reading abilities (accuracy and fluency) and rapid naming (RAN) over word reading fluency. Letter knowledge (LK) and phonological awareness (PA) for literacy were accounted for as control factors due to their ceiling effects. We test the direct impact of the main predictors and their indirect outcomes by controlling for word reading accuracy. To this end, 206 children participated and completed measures for nonword reading abilities, rapid naming, word reading accuracy, fluency, and letter knowledge, and phonological awareness. The results show that RAN and nonword reading accuracy are direct predictors of word reading accuracy. Word reading fluency is significantly associated with rapid naming. The effect of RAN, nonword reading accuracy, nonword reading fluency on word reading fluency is partially mediated by word reading accuracy. We discuss the practical implications.
Educational Attainment and Financial Well-being in Romania
Authors:   National Scientific Research Institute for Labour and Social Protection, Zamfir Ana-Maria , Năstasă Anamaria ,   National Scientific Research Institute for Labour and Social Protection, Molea Raluca Mihaela ,   National Scientific Research Institute for Labour and Social Protection
Published: February 2022

In contemporary societies, education facilitates social mobility and well-being of individuals. According to human capital theory, people who invest in themselves through education and training have improved chances of getting better jobs and gaining higher income (Becker et al., 1990; Woodhall, 1987). This paper aims to examine the effects of educational attainment on financial well-being in Romanian context. We analyse statistical data from the World Values Survey Wave 7 (sub-sample for Romania) collected from 1257 subjects. By exploring the relation between educational attainment and financial well-being, our results are relevant for better understanding the mechanisms linking human capital accumulation to monetary benefits and how these mechanisms work in relation to various individual and contextual factors.
Psycological Adaptation of Children in Remarried Families
Authors:   Khmelnytskyi National University, Rudenok Alla , Petyak Olena ,   Ph. D. in Psychology, Senior Lecturer at the Department of Psychology and Pedagogy, National University of Khmelnytskyi, Komar Taisiia ,   Doctor of Psychological Sciences, Associate Professor, Professor of Psychology and Pedagogics Department, Humanities Faculty, National University of Khmelnytskyi, Afanasenko Valentyna ,   Doctor of Philosophical Sciences, Associate Professor, Department of Psychology, Cherkasy Regional Institute for Postgraduate Education of Teachers, Khanetska Natalia ,   Ph. D. in Psychology, Assistant Professor, National University of Khmelnytskyi
Published: February 2022

The aim of the article is to study the child-parent relationship, the peculiarities of the state of socio-psychological adaptation of children of different ages in remarried families. The following methods were used in the study: author's questionnaire "Family of remarriage" (Matsenko, 2015), projective technique "Family Drawing" by A. Wenger (2003); questionnaire "Analysis of family relationships" by E. Eidemiller, V. Justickis (2001); questionnaire " Social Adaptability" by A. Furman (2000); method of diagnosis of socio-psychological adaptation of K. Rogers and R. Dymond (Lemak & Petrishche, 2012). According to the typology of remarriages according to T. Argentova and V. Kolotylina, there are two important conditions: 1) whether or not there are children from previous marriages; 2) whether or not there are children in a new family. The results of the research showed statistically significant differences in the child's perception of her new remarried family depending on its type. In type 1 families, the child's relationship with the new family member is formed favorably. It has been proven that having a child together in a remarried family significantly changes the family situation. Children raised in type 3 families, where the new husband did not have children of his own, but had a child together, in contrast to children from type 4 families, develop a much better relationship with the stepfather. There is a deterioration in the attitude to the stepson in connection with the spouses having children together in a new marriage. The conclusions establish the specifics of parent-child relationships in remarried families. The specifics of parent-child relationships in remarried families depend to a large extent on the age of the child, on whether the stepfather or mother has children from previous relationships, and on whether children are born into the new marriage.
Racial Capitalism and Outdoor Adventure Education: Challenging Inequity and Reimagining Connection, Community, and Place
Authors: Goodman Cecil
Published: February 2022

This paper argues that the adoption of theories of racial capitalism as a framework for analysis can help shift dominant pedagogies in Outdoor Adventure Education (OAE) to not just be more inclusive, but to reimagine ways that communities of outdoor education, recreation, and leadership can build awareness of the reproduction of the Wilderness and the Outdoors in the U.S. as a racialized and gendered space and build more racially and gender diverse and equitable communities in OAE and related fields. To do this, I trace the social formation of Wilderness as a racial capitalist project and examine the historical and current implications for OAE. Specifically, I explore a common curricular area of OAE, sense of place, while applying a theoretical framework of racial capitalism. This paper is intended to serve as a resource and a call to action for members of the outdoor education, recreation, and leadership communities to disrupt racial and gender inequity in outdoor learning communities.
Community Wellness and Social Support as Motivation for Participation in Outdoor Adventure Recreation
Authors: Zwart Ryan , Hines Ryan
Published: February 2022

In recent decades, researchers and land managers have seen steadily increasing numbers of outdoor adventure recreation (OAR) participation. Social and community support have long been topics in outdoor recreation literature. The following study aimed to further explain to what extent social and community support and well-being occur because of OAR participation and how important social and community components are to outdoor adventure recreation participants. This study interviewed participants of three OAR activities including, rock climbing, mountain biking, and whitewater paddling. Results from this study revealed two emergent themes related to socially oriented motivations of participation, which include shared experience in nature as well as social and community aspects of participation. The study also includes activity specific social aspects of motivation for participation. Connections of findings to current understanding of OAR are made and supported in the discussion, as well as considerations for future study.
Developing Manageable Individualised Formative Assessment of Translator Trainees Through Rubrics
Authors: Way Catherine
Published: February 2022

For some time now I have implemented a manageable combined assessment approach emphasising competence and decision-making (Way 2008, 2009). To do this, we must be able to monitor trainees’ planning, monitoring, regulating, evaluating, recognition of flawed and successful processes and task variables during their assignments. The question is: How can translator trainers assess such a vast range of complex processes? One possible solution is through rubrics for each trainee project management role and for the final translation. In this proposal we attempt to counterbalance the multiple demands of trainee assessment, whilst also addressing the time constraints on trainers and the opinions of trainees. In our paper we will present the rationale for the rubrics (after the pilot trial February-June 2020), one rubric example, an example of the Support Sheets for trainees and the outline for a platform which, once constructed, will only require periodical updating by trainers.
Nipping-Agronomic Approach for Enhancing the Pulses Production: A Review
Authors: Ammaiyappan A. , Paul R. Arockia Infant , Selvakumar S.
Published: February 2022

Pulses are an important protein source for vegetarian people across the world and they have a great potential to improve the human health, contribute to global food and nutritional security. Variety of pulses were grown in India with 25% of global production and 27% of global consumption. Though India is the largest pulses producer in the world, it imports around 3.5 million tons annually to meet the ever-increasing requirement. Less adoption of improved Agro techniques, low fertile soils and unpredictable environment conditions are major factor for low production of pulses. As a results of increasing population, the projected pulses requirement will be 32 million tons by 2030 which necessitate annual growth rate of 4.2%. With adoption of suitable agronomic strategies, the productivity has to be enhanced to meet the demand. This review work was done at Department of Agronomy, Agricultural College and Research Institute, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India. Collected review and research papers were screened from various data base like TNAU e library, ARCC journals, google scholar, research gate and scopus used to write this paper. This review article documented information gathered on importance of pulses, area, production and productivity of pulses. Nipping is important agronomic practices that removes the apical bud dominance and promotes the lateral growth which turn better maintenance of source and sink relationship and enhance the pulses yield. Influence of nipping on growth and yield of various pluses crops has been discussed here.
Development of the European Union’s environmental policy and its measures for climate protection – a review
Authors: Gabnai Zoltán
Published: February 2022

The negative impacts of human activities on the environment and nature can be felt worldwide. Thus there is a growing focus on measurements that keep sustainability in mind. As one of the main pioneers of environmental protection and sustainability efforts, these aspects are more and more prevalent in the current environmental policy of the European Union (EU). In this review article, the development of the environmental policy of the EU is presented. After listing the main milestones, the role of the EU in the area of environmental protection, the frameworks built around the goals and the roles of the institutions are discussed. Then – with an international detour – the details of the Paris Agreement about climate change and the state of the 20/20/20 commitments are summarised. In the remaining parts of the article, the focus is on the climate protection goals of the EU for the next three decades, the expected future directions, and the agenda of the von der Leyen Commission concerning climate protection. An important step and tool for achieving the goals set until 2050 is to incorporate climate and environmental protection elements to the 2021-2027 budget of the EU. In order to achieve the expected effects, it is crucial to develop the right tools of the environmental policy, to form a widespread cooperation, to raise awareness, and incentivise and support the innovative solutions in the sustainability area.
Effectiveness of Wastewater Treatment Installation and Liquid Waste Quality in Dr. Soetomo General Hospital, Surabaya
Authors: Dewi I'anatul Ulya , Azizah R , Husnina Zida , Sumantri Arif , Qomariah Nurul , Suhariono Suhariono , Jauharoh Siti N. A. , Latif Mohd
Published: February 2022

Introduction: Hospitals are institutions that produce liquid waste that may pollute the environment and have a dangerous impact on health. Hospital waste has the potential to contain hazardous chemicals, pharmaceutical waste, radioactivity and microbiological pathogens in liquid waste that can pollute the environment and disrupt the balance of the ecosystem. This study aims to determine the effectiveness of the Wastewater Treatment Plant (WWTP) and the quality of the liquid waste at the Dr. Soetomo General Hospital. Methods: This research was a quantitative descriptive study using secondary data from laboratory analysis of wastewater inlet and outlet of The Central Wastewater Treatment Plant (WWTP) of Dr. Soetomo General Hospital for the January-December 2020 period. Effectiveness was obtained by calculating the difference between the inlet and outlet values of each parameter divided by the inlet value multiplied by 100%. Results and Discussion: WWTP in Dr. Soetomo General Hospital Surabaya used a central WWTP which had 3 (three) units, namely WWTP Sequence Batch Reactor (SBR), WWTP Membrane Biostrain Reactor (MBR) and WWTP Aerobic Biofilter which aims to improve the quality of liquid waste. Based on the results of the research analysis, it has been found that hospital wastewater treatment using a central WWTP system is effective for reducing the levels of parameters, namely Total Suspended Solid (TSS) by 60.55%, Biological Oxygen Demand (BOD) by 72.52%, Chemical Oxygen Demand (COD) by 54.02%, Ammoniacal Nitrogen (NH3N) by 90.91%, Phospate (PO4) by 71.43%, bacteria group E. Coli by 99.93%. The temperature and Potential of Hydrogen (pH) parameters recorded at the outlet are in accordance with the established quality standards. Conclusion: The three WWTP units used in Dr. Soetomo General Hospital are able to treat liquid waste effectively. Liquid waste at each outlet parameter is in accordance with East Java Governor Regulation No. 72 of 2013 concerning quality standards for health facilities waste water, so that the effects of contamination on the environment can be minimized.
EATING VEGETABLES BEFORE CARBOHYDRATES DECREASE ENERGY INTAKE OF TYPE-2 DIABETES MELLITUS PATIENTS
Authors: Widyasari Dian Eka , - Sugiarto , Indarto Dono
Published: February 2022

Diabetes mellitus is a non-communicable disease that has increased significantly in Indonesia and worldwide. Dietary arrangements through diet therapy are beneficial for improving the performance of the pancreas in producing and stimulating the work of insulin. This study aimed to determine the effect of the order of vegetable and carbohydrate consumptions on the decrease of energy intake. Method used randomized control trial with pre-post design.  A total of 24 people with non-complicating type-2 diabetes mellitus aged 18-65 years were assigned into 3 groups ; control group (C), vegetable before carbohydrate group (P1), and vegetable with carbohydrate group (P2) .  Energy intake before and after the intervention was measured using a 24-hour food recall. To compare pre-post intervention, paired T-test were used, meanwhile to compare difference among groups data were analysed using ANOVA.  A significant decrease in energy intake was found in P1 where the mean values of C and P1 were 17.75 ± 12.40 calories and 155.27 ± 23.40 calories (p < 0.001), and mean values of P1 and P2 were 155.27 ± 23.40 calories and 4.54 ± 48.99 calories (p < 0.001). The order of vegetable before carbohydrate consumption decreases energy intake of type-2 diabetes mellitus patients.
HUBUNGAN POLA KONSUMSI SUMBER ZAT BESI, INHIBITOR DAN ENHANCER ZAT BESI DENGAN KEJADIAN ANEMIA PADA SANTRIWATI PONDOK PESANTREN AL-MIZAN MUHAMMADIYAH LAMONGAN
 Correlation between consumption patterns of iron sources, iron inhibitor, and iron enhancer, with the occurence of anemia among female students in Islamic Boarding School Al-Mizan Muhammadiyah Lamongan

Authors: Nabilla Fanti Septia , Muniroh Lailatul , Rifqi Mahmud Aditya
Published: February 2022

Anemia merupakan salah satu permasalahan defisiensi zat gizi yang rentan dialami oleh remaja putri. Anemia adalah kondisi dimana kadar hemoglobin (Hb) lebih rendah dari 12 g/dL. Anemia dapat disebabkan karena kekurangan darah, penyakit infeksi, rendahnya kandungan zat besi pada makanan, rendahnya konsumsi makanan sumber zat besi dan terdapat zat yang dapat menghambat absorbsi zat besi pada makanan. Mengonsumsi sumber zat besi dan enhancer zat besi serta mengurangi konsumsi inhibitor dapat meningkatkan absorbsi zat besi dalam tubuh. Penelitian ini bertujuan untuk menganalisis hubungan antara pola konsumsi sumber zat besi, inhibitor zat besi dan enhancer zat besi dengan kejadian anemia pada santriwati. Penelitian ini menggunakan desain cross sectional pada 50 santriwati kelas X dan XI di Pondok Pesantren Al-Mizan Muhammadiyah Lamongan. Pemilihan sampel menggunakan metode proportional random sampling. Kadar hemoglobin diukur menggunakan alat hemoglobinmeter digital dan data pola konsumsi dikumpulkan menggunakan food frequency questionnaire. Analisis data menggunakan uji korelasi Spearman. Penelitian ini menemukan hubungan antara pola konsumsi sumber zat besi (p=0,036) dan inhibitor zat besi (p=0,012) dengan kejadian anemia. Tidak ada hubungan antara pola konsumsi enhancer zat besi (p=0,339) dengan kejadian anemia. Kebiasaan mengonsumsi sumber zat besi dan inhibitor zat besi dapat meningkatkan kadar zat besi dalam tubuh terutama zat besi heme dan mengurangi konsumsi pangan inhibitor zat besi untuk menurunkan risiko terjadinya anemia.
KUALITAS PELAYANAN E-KTP (Studi Pada Pelayanan Kartu Tanda Penduduk Elektronik (KTP-el) Pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Hulu Sungai Tengah)
Authors: Hadiyanor Enly , Widyanti Febi
Published: February 2022

Tujuanpenelitianiniadalahuntukmengetahui kualitas pelayanane-KTP pada DinasKependudukandan Pencatatan Sipil KabupatenHulu Sungai Tengah.Teori yang digunakan mengacu kepada standar pelayanan publik yang ditetapkan UU No. 25 Tahun 2009 Tentang Pelayanan Publik, yaitu prosedur, waktu penyelesaian, biaya pelayanan, sarana dan prasarana, kompetensi petugas. Metode yang digunakan adalah kualitatif  dengan tipe deskriptif.Jenisdatayangdigunakanberupadataprimerdandatasekunder.Teknikpengumpulan datadengan observasi,wawancara, dandokumentasi, serta interaktif model analysis Miles and Huberman (2005). Hasil  penelitianmenunjukkanbahwa kualitas pelayanan e-KTP) pada DinasKependudukandanPencatatanSipilKabupatenHuluSungaiTengah terkategori cukup baik, berdasarkan analisis indikator standar pelayanan publik.
TRANSFORMAÇÕES URBANAS EM FORMOSA-GOIÁS
Authors: Gomes João Gabriel
Published: February 2022

As transformações do espaço urbano são um dos grandes temas discutidos na Geografia. Em sua maioria esses debates giram entorno das grandes e médias cidades, marginalizando as cidades pequenas. Entretanto, várias das interações sócio urbanas presentes nas grandes metrópoles bem como as relações dos citadinos são reproduzidas em menor escala nas pequenas cidades. Deste modo, o presente artigo busca trabalhar possíveis alterações nos espaços urbanos de Formosa –GO, um cidade interiorana que apresenta relações urbanísticas de grandes centros com alterações em percepção de escala. O artigo aborda um recorte temporal dos anos de 2015 até 2021 buscando entender os autores responsáveis pelas transformações nas paisagens e nos lugares do urbano formosense. O artigo parte de um profundo levantamento teórico e utiliza como método o materialismo histórico geográfico presente em Harvey.
POTENCIALIDADES E FRAGILIDADES DA ESTRUTURA HÍDRICA DO TERRITÓRIO DO RIO GRANDE DO NORTE
Authors: Lopes Bruno , Troleis Adriano Lima
Published: February 2022

Os recursos hídricos de um determinado território podem apresentar diferentes características no que diz respeito a sua disponibilidade. No caso de estados afetados por longos períodos de seca, como o Rio Grande do Norte, essa disponibilidade tende a ser afetada. Por esse motivo, objetiva-se com essa discussão analisar as fragilidades e as potencialidades hídricas do Rio Grande do Norte, no período compreendido entre 2015 e 2017. Esse objetivo foi alcançado mediante a aplicação de um conjunto de procedimentos metodológicos, como pesquisa bibliográfica sobre recursos hídricos; obtenção de dados hidrológicos junto órgãos oficias; e produção de mapas temáticos dos recursos hídricos do Rio Grande do Norte. Constatou-se nessa análise que entre 2015 e 2017, mais de 90% dos municípios do estado decretaram calamidade por conta da seca, o que é um indicador de fragilidade hídrica.
RELATOS DE TRABALHO DE CAMPO NO PARQUE ESTADUAL DA SERRA DOURADA (GOIÁS):
Authors: Mateus Natalia Barbosa , Morais Márcio José Pires de , Oliveira Sebastião de Souza , Carneiro Vandervilson Alves
Published: February 2022

A geograficidade de paisagens abióticas consiste numa gama de ambientes hidrológicos, espeleológicos, paleontológicos, geológicos e geomorfológicos. Tal sejam as naturezas de cada elemento, tomada em seu conjunto dão origem a variedades de paisagens.  Entende-se por natureza de tais elementos, do ponto de vista macro, a localização, o clima, a dureza dos minerais, fósseis, tipos de relevo que se materializam em eventos do tipo falhas, dobras, quedas d’água, canais fluviais, cavernas, mirantes, afloramentos e outros. Este trabalho cumpre a responsabilidade de uma pesquisa acadêmica, na referida temática, sem perder de vista potencial uso destas experiências com outras instituições de ensino e sociedades como um todo. Essa iniciativa, todavia, responsabiliza os autores e o Curso de Mestrado em Geografia da Universidade Estadual de Goiás (UEG), Campus Cora Coralina (Cidade de Goiás / GO) realizada no Parque Estadual da Serra Dourada (GO) em 16/06/2019. Dado que por meio de fotografias, narrativas e descrição dos componentes naturais, podem-se concluir os objetivos. Percebeu-se que os pontos visitados apresentam o potencial necessário de auxiliar e de fundamentar explicações ligadas ao ensino de Geociências, de Geografia com destaque para a Geodiversidade em ambiente de Cerrado.
Virtual Screening of Selected Phytochemicals From Four Antimalarial Plants Predicted Potential Inhibitors of Wild Type and Mutant Forms of Dihydrofolate Reductase-Thymidylate Synthase in Plasmodium sp.
Authors: Ikegbunam Moses , Ejiofor InnocentMary , Duru Vincent , Akachukwu Amarachi , Oranu Emmanual , Okoyeh Jude Nnaemeka , Egieyeh Samuel
Published: February 2022

Resistance to Pyrimethamine, an antimalarial medicine has been reported to be due to mutations in Dihydrofolate reductase-thymidylate synthase (DHFR-TS). Phytochemicals, particularly from plants that been used in ethnomedicine, have been reported to have privileged structures that might bind strongly to the mutants of DHFR-TS. The aim of this study is to identify phytochemicals of Acalypha wilkesiana, Cymbopogon citratus, Azadirachta indica, and Morinda lucida with high binding affinities for the Plasmodium falciparum DHFR-TS. The three-dimensional structures of the phytochemicals, wide type and mutant forms of DHTR-TS were obtained from PubChem and Protein Databank (PDB) respectively. They were appropriately prepared and molecular docking simulations was implemented to predict binding affinities of the phytochemicals to the wildtype and mutant forms of DHTR-TS. Druglikeness assessment was implemented to triage the top binding phytochemicals and molecular dynamics simulations was done to establish the stability of the interaction of the top-ranked phytochemical with one of the mutants of DHFR-TS. Nineteen phytochemicals showed higher binding affinities to both the wild type and mutant forms DHFR-TS than Pyrimethamine. Molecular dynamics revealed that the receptor-ligand binding of luteolin, the top-ranked, drug like phytochemicals, to the quadruple mutant was stable.
A Novel Application of 3D Printing Technology Facilitating Shell Wound Healing of Freshwater Turtle
Authors: Hung Tsung-Fu , Kuo Po-Jan , Nai Yu-Shin
Published: February 2022

Numerous cases and a shortage of resources usually limit wild animal rescue. New technology implemented might save these severely injured wild animals from the situation of euthanasia by easing the requirement of intensive medication. Three-dimensional (3D) technologies provide precise and accurate results that improve the quality of the medical application. These 3D tools have become relatively low-cost and accessible in the past years. In the medical field of exotic animal, turtle shell defect is highly challenging because of inevitable water immersion. This report is the first attempt to apply the combination of 3D scanning, computer-aid design (CAD), and 3D printing to make a protective device that frees the wound from exposure to water or infection sources. The presenting techniques successfully extricate a wild freshwater turtle from an extensive shell defect within a short period. Integration of multiple sciences to 3D technology can provide a facile model for veterinary medical applications.
Fly Ash Composites: A Review
Authors: Saha Mainak
Published: February 2022

The present decade has witnessed numerous investigations focussed on the determination of the mechanical properties of Fly ash composites. These composites have attracted attention, especially in the form of reinforcements owing to their excellent tensile and compressive properties coupled with impact and hardness response. A number of techniques viz. in-situ deposition, hand-up lay and compo-casting techniques have been reported to fabricate these composites. However, in the context of these composites, a systematic structure-property correlation has not been established till date. The present review is aimed at highlighting the current state of research in the avenue of Fly ash composites from two different viewpoints, viz. (i) fabrication technique and (ii) mechanical properties of the fabricated composites. Moreover, the necessity of establishing systematic structure-property correlation in these materials has also been briefly discussed from the author’s viewpoint.
Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections Preliminary Considerations and Conclusions from a Non-interventional Study
Authors: Wagenlehner Florian , Lorenz Horst , Ewald Oda , Gerke Peter
Published: February 2022

Urinary tract infections (UTIs) are very frequent in women and can be caused by a range of pathogens. High recurrence rates and increasing antibiotic resistance of uropathogens make UTIs a severe public health problem. d-mannose is a monosaccharide that can inhibit bacterial adhesion to the urothelium after oral intake. Several clinical studies have shown the efficacy of d-mannose in the prevention of recurrent UTI; these also provided limited evidence for the efficacy of d-mannose in acute therapy. A recent prospective, non-interventional study in female patients with acute cystitis reported good success rates for treatment with d-mannose. Here we present data from a post-hoc analysis of this study to compare the cure rate of d-mannose monotherapy with that of antibiotics. The results show that d-mannose is a promising alternative to antibiotics in the treatment of acute uncomplicated UTIs in women.
Measurement of Loudness Discomfort Levels as a Test for Hyperacusis: Test-Retest Reliability and Its Clinical Value
Authors: Vidal Jaclyn Leigh , Park Jung Mee , Han Jae Sang , Alshaikh Hamzah , Park Shi Nae
Published: February 2022

Objectives. The aims of this study were to investigate the test-retest reliability of measurements of loudness discomfort levels (LDLs), to suggest cut-off values for diagnosing patients with hyperacusis, and to evaluate the clinical value of-LDL measurements as a test for monitoring hyperacusis.Methods. For the test-retest reliability of LDL measurements (study 1), a total of 68 patients who sought consultations at our clinic were subcategorized into four groups: patients with tinnitus (group 1), tinnitus and hearing loss (group 2), hyperacusis (group 3), and normal controls (group 4). Inter-hour and inter-day test-retest reliability values using different stimuli were investigated. For study 2, the clinical value of LDL measurements using pure tone stimuli was analyzed by comparing changes after sound generator use in patients with hyperacusis.Results. In study 1, the group 3 patients showed significantly lower LDLs than the other groups. High test-retest reliability of LDL tests was demonstrated, regardless of the type of stimulus used. The cut-off values for screening patients with hyperacusis were 90 dB HL using pure tone stimuli and 62 dB HL using white-band noise stimuli. In study 2, significantly increased LDLs were correlated with improved symptoms and improved scores on tinnitus questionnaires after sound generator use, indicating that LDL measurement is a reliable test for monitoring hyperacusis during an intervention.Conclusion. LDL measurement is a reliable diagnostic tool to reflect the condition of hyperacusis, especially during the course of treatment.
Percutaneous Screw Stabilization of Non-Periacetabular Pelvic Lesions Caused by Metastatic Cancer and Multiple Myeloma
Authors: Yang Rui , Singh Swapnil , Falk Alessandra , Wang Jichuan , Thornhill Beverly , Fox Jana , Sen Milan , Hoang Bang , Geller David S.
Published: February 2022

Background:

The pelvis is one of the most common locations for metastatic bone disease. While many of the publications that describe surgical treatments focus on periacetabular lesions (Enneking zone II), there is a lack of investigation into lesions in the non-periacetabular areas (zones I, III, and IV). We recently described a minimally invasive percutaneous screw application for metastatic zone-II lesions with excellent results. In the present study, we aimed to extend this approach to the other pelvic areas.

Methods:

Twenty-two consecutive patients with painful non-periacetabular pelvic metastatic cancer were included based on retrospective chart review. There were 16 women and 6 men with an average age of 60 years (range, 36 to 81 years). The most common primary cancers were multiple myeloma (7 cases) and breast (5 cases). The most common locations were the sacrum and the ilium. A pathologic fracture was identified in 15 patients. Most of the lesions were treated with multiple large-diameter screws, except for the isolated zone-III lesions. All of the procedures were completed in a standard operating room without the need for special instruments. Radiation therapy was given to 19 patients; the average dose was 15 Gy. The studied outcomes were pain and functionality as assessed by a visual analog scale (VAS) score and the Eastern Cooperative Oncology Group score (ECOG), respectively.

Results:

There were no surgical complications and no need for blood transfusion. The average follow-up time was 7 months (range, 0.3 to 34.0 months). Two patients died within 4 weeks of surgery due to COVID-19 infection. There was significant improvement in the postoperative VAS pain score (p < 0.0001) and the ECOG score (p < 0.05) when compared with the preoperative scores. There was no implant failure or revision surgery. Local bone-healing was observed in 12 of 14 patients (86%) who survived for >3 months after surgery.

Conclusions:

Percutaneous screw application is safe and effective in the treatment of metastatic non-periacetabular pelvic lesions. Given the simplicity of the technique and the instrumentation and the tolerance for concomitant treatments, this approach is worthy of broader consideration.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
EFFECT OF METHANOL EXTRACT OF CLINACANTHUS NUTANS ON SERUM BIOCHEMICAL PARAMETERS IN RATS
Authors:   Pâ€™ng Xiu Wen, Wah Peng Tiew
Published: February 2022

The present study aims to evaluate in vitro free radical scavenging activity of methanol extract of Clinacanthus nutans and the effect of the extract on liver and kidney function parameters in normal rats. The free radical scavenging activity was estimated by using DPPH assay.
IN-VITRO ANTIVIRAL ACTIVITY OF PISTACIA CHINENSIS FLAVONOIDS AGAINST HEPATITIS C VIRUS (HCV)
Authors:   NoÃ©mie Calland, Rashed Khaled
Published: February 2022

The present study was designed to evaluate anti-HCV activity of Pistacia chinensis aerial parts and identify the responsible bioactive constituents of anti-hepatitis ethnomedicinal plant P. chinensis methanol 80% extract. This has led to the isolation and characterization of gallic acid and eight flavonoids, apigenin, diosmetin, myricetin, apigenin 7-O-Î²-glucoside, quercetin 3-O-Î²-glucoside myricetin 3-O-Î±-rhamnoside, myricetin 3-O-Î²-glucuronide and quercetin 3-O-Î²-glucoside-7-O-Î±-rhamnoside from the plant, using various chromatographic procedures and the interpretation of spectral data in comparison with already existing data reported in the literature.
Implementation of the Distribution Requirement Planning Method in Optimizing the Distribution of Packaged Drinking Water Products
Authors: Handayani Nurlaila , Nadya Yusri , Maulana Dwi
Published: February 2022

CV Athaya Mineral is an industry that runs its business in the production and distribution of bottled drinking water. At the time of distribution of its products, errors often occur, namely the interpretation of demand data in each distribution chain and information received. The purpose of this study was to determine the optimal lotting technique for the distribution of these products using the Distribution Requirement Planning (DRP) method. From the results of data processing, the retail value of Kede Osa was obtained with a total cost of Rp. 233.696, New Store retail with an amount of Rp. 417,336, retail Ari JP Rp. 99,727, Simpang Remi retail Rp. 165,140, retail Mita Jaya Rp. 619,981. The conclusion of this study is the distribution of the Distribution Requirement Planning method for all Dance products (Glass, Small Bottles, Medium Bottles, and Gallons) to five retailers (Kede Osa, Toko Baru, Ari JP, Simpang Remi, and Mita Jaya) using Economic Order Quantity (EOQ) is a lotting technique with the cheapest distribution costs, except for New Store retailers using the Lot For Lot (LFL) lotting technique.
Implementation of flexible vegetation into CSHORE for modeling wave attenuation
Authors: Ding Yan , Chen Q. , Zhu Ling , Rosati Julie , Johnson Bradley
Published: February 2022

This technical report presents the new numerical modeling capabilities for simulating wave attenuation and mean water level changes through flexible vegetation such as smooth cordgrass in coastal and marine wetlands. These capabilities were implemented into the Cross-SHORE (CSHORE) numerical model. The biomechanical properties of vegetation such as dimensions, flexibility, and bending strength are parameterized in terms of the scaling law. Correspondingly, a new formulation of the vegetation drag coefficient, CD, is developed using field data from a salt marsh in Terrebonne Bay, LA, by considering spatially varying effective stem and blade heights of species. This report also presents a general procedure for using the model to simulate hydrodynamic variables (i.e., waves, currents, mean water levels) at vegetated coasts, which are used to quantify the effects of wave attenuation and reduction of surge and runup due to vegetation. Preliminary model validation was conducted by simulating a set of laboratory experiments on synthetic vegetation, which mimicked the flexibility of Spartina alterniflora. The validation results indicate that the newly developed vegetation capabilities enable CSHORE to predict changes of wave heights and water levels through marshes by considering species-specific biomechanical features. The model is also applicable to assess vegetation effectiveness against waves and surges.
Scaling of Multiphase Flow in Simple Heterogeneous Porous Media
Authors: Zhou Dengen , Fayers F. J. , Orr F. M.
Published: February 2022

The nature of flow in porous media is determined by the interaction of the physical properties of the medium and fluids, and by the interplay of various forces involved in the displacement process. Identifying flow regions at a given reservoir operating condition is a key issue in forecasting reservoir performance and hence of optimizing operations. This work identifies dominant flow regions at various conditions. Three dimensionless groups, NgvM/(1 + M) (gravity/viscous ratio), NcvM/(1 + M) (capillary/viscous ratio) and Ri2 (shape factor), are defined and used to resolve flow regions. The analysis shows that the relative magnitudes of forces involved in the system combined with the reservoir properties determine the flow region and fluid distribution in the medium.

By choosing appropriate ranges for the dimensionless numbers, recovery processes can be specified from the general theory, and the boundaries to flow regions confirmed by comparison with existing experimental and simulation results. Three commonly studied flow systems have been investigated, which are miscible displacements without dispersion (Ncv ≈ 0) in layered reservoirs, immiscible displacements (Ngv ≈ 0) in layered and homogeneous media, and flow in highly fractured reservoirs.
Evolutionary conservation of the fidelity of transcription
Authors: Chung Claire , McGann Eric , Verheijen Lambertus , Navapanich Zoe , Shemtov Sarah , Lai Guan-Ju , Towheed Atif , Haroon Suraiya , Holczbauer Agnes , Chang Sharon , Manojlovic Zarko , Simpson Stephen , Thomas W. Kelley , Kaplan Craig , Hasselt Peter van , Timmers H.Th.Marc , Erie Dorothy A. , Chen Lin , Gout Jean-Francois , Vermulst Marc
Published: February 2022

Accurate transcription is required for the faithful expression of genetic information. Surprisingly though, little is known about the molecular mechanisms that control the fidelity of transcription, or the conservation of these mechanisms across the tree of life. To address this issue, we measured the error rate of transcription in five organisms of increasing complexity and identified various genes, alleles and processes that control transcriptional fidelity in multicellular organisms. In doing so, they highlight the evolutionary conservation of fidelity factors and open up new opportunities to probe the impact of transcription errors on intact organisms and human physiology. Finally, our experiments provide the first reasonable estimate of the error rate of transcription in human cells, identify the first disease associated with error-prone RNA polymerases and suggest that transcription errors may have contributed to the evolution of our genetic code.
WITHDRAWN: The Ecological Biases of Zooplankton Invasions: Taxonomic, Geographical And Methodological Perspectives
Authors: Pedroso Clemerson Richard , Vitule Jean Ricardo Simões
Published: February 2022

The introduction of non-native species is one of the most important causes of biodiversity loss. Non-native organisms are not recognized by native communities, leading to differential predation rates and differential impacts on a variety of ecological interactions. In this context, the present study was intended to carry out a review of the literature on the impacts of non-native zooplankters on the zooplankton and the dynamics of aquatic ecosystems--literature reviews are a valuable tool that can highlight gaps and find possible biases in our understanding of biological invasions. We carried out a review of the current literature (20 years) looking for any alteration in the natural dynamics of the environment at all ecological levels. A total of 181 studies that addressed some type of non-native zooplankton effect were included in the review. Most studies focused on a just few non-native species and evidenced demographic changes at the population level. A geographic bias in favor of North America was also found. The various gaps in the literature on non-native zooplankton are derived from the same problem, an excessive number of investigations of the same taxa in the same places. Consequently, the recorded impacts are similar since they come from the same groups, and neglect less studied, but not necessarily less impactful, species. A greater focus on studies of lesser-known species could generate more comprehensive knowledge about the effects of non-native zooplankton and contribute to the distribution of conservation efforts beyond the better-known species.
A Machine Translation Like Approach to Generate Business Process Model From Textual Description
Authors: Sonbol Riad , Rebdawi Ghaida , Ghneim Nada
Published: February 2022

Modeling is one of the core tasks in Business Process Management (BPM). It represents the most critical step in the BPM life cycle and is considered as a time consuming and costly task. These challenges raised the question of how researchers can save this cost by building tools that could support modeling experts in their work to reduce the manual workload. In this paper, we propose a Machine Translation (MT) like approach to deal with the problem of generating a business process model based on a textual description. We chose to follow a semantic transfer-based MT approach. Our approach consists of two main phases: The natural Language Analysis phase and BPMN diagram generation. Natural Language Analysis phase aims to analyze the text and extract the required knowledge. One of the main outputs for this phase is a Concept Map which summarizes the concepts of the related domain and the relationships between these concepts. This map represents a background for our processing in the second phase where we try to generate the "translation", which is the BPMN diagram in our case. We achieve our goal in the second phase via a set of semantic, syntactic, and morphological manipulations. The approach has been implemented and evaluated using a similarity metric based on the Graph Edit Distance. The results show that the proposed approach was able to generate models that are more than 81% similar to those created manually by a human, outperforming the state of the art in this topic.