bluuebunny/crossref_metadata_2025 huggingface dataset:
A Leadership Model for the Optimal Institutionalisation of a Results-Based Performance Measurement and Management Culture in the Agricultural and Natural Resource Sector of Ethiopia
Authors: Kidanemariam Messele Gebregziabher , Henning Sanchen
Published: May 2023

The aim of the study was to construct a leadership model that drives the optimal institutionalisation of a results-based performance measurement and management (RBPMM) culture in the agricultural and natural resource sector of Ethiopia. A concurrent mixed-methods design was adopted for the research. The quantitative study comprised a total sample of 228 respondents, and face-to-face interviews were conducted with 20 key informants. The primary researcher administered a self-developed instrument with 167 items to the respondents, and made a discussion guide available to them in both English and Amharic. The methods of data analysis included various multivariate analysis methods and a structural equation analysis. A thematic content analysis was done to identify the themes emerging from the qualitative data. The direct influence of the independent variable of leadership roles and tasks on the optimal institutionalisation of an RBPMM culture was positive but not significant. Indirectly, this variable significantly influenced the indicator variables of the optimal institutionalisation of an RBPMM culture through the mediating variables of leading and managing for an institutionalised RBPMM culture. The adoption of performance measurement information for control and compliance purposes was evident in the Managing Environmental Resources to Enable Transition (MERET) programme, but its implementation to optimise decision-making, accountability and transparency was not evident. These results were confirmed by triangulating the qualitative findings with the quantitative results. The limitation of the study was that it focused on a specific region and a public service project in Ethiopia within a specific time frame and context. Therefore the study may not be representative of similar programmes in the private sector. Also, it was not a longitudinal study that tracked changes over time. The study contributes to scholarly discourse and the existing body of knowledge by presenting a leadership model that drives and optimally institutionalises an RBPMM culture in agricultural development programmes in Ethiopia. This model could be implemented in other developing economies as well. The mediating variables can be adopted by policy-makers and organisational practitioners for the optimisation of the institutionalisation of an RBPMM culture.
CT-peritoneography in diagnosis of patent processus vaginalis in peritoneal dialysis
Authors: Jayanthan S. Shanmuga , Nadanasadharam K. , Dwarak S. , Annamalai P. R.
Published: May 2023

Patent processus vaginalis is a congenital condition characterized by persistent communication between the scrotum and peritoneal cavity which is associated with pathologies like congenital hydrocele/hernias. Asymptomatic patent processus vaginalis may become clinically evident in patients undergoing peritoneal dialysis, who may present with unilateral scrotal edema following dialysis. Conventional plain computed tomography (CT) may be difficult to identify the communication, especially if small, and in such cases, CT peritoneography will be useful to detect the patent processus vaginalis.
ANALYSIS OF LIGAND RECEPTOR INTERACTIONS OF ADRENALINE WITH ARTERIAL RECEPTORS DURING ADAPTATION TO COLD BY THE LINIOVER – BURKE AND SKETCHARD METHOD
Authors: Ананьев В.Н. , Ананьев Г.В. , Прокопьев Н.Я. , Ананьева О.В. , Гуртовой Е.С.
Published: May 2023

Адаптация организма к холоду требует многогранной перестройки работы многих функциональных систем организма. Особую роль при адаптации к холоду играет симпатичекая нервная система и ее нейромедиаторы норадреналин и адреналин. В нашей работе исследованы рецепторные механизмы регуляции тонуса артерий конечности кролика на нейромедиатор адреналин при 10 дневной холодовой адаптации. Изучены фармакокинетические и фармакодинамические изменения реактивности альфа-адренорецепторов артерий к адреналину методом Лайнуивера – Берка и Скетчарда. это позволило определить количество активных а-адренорецепторов артерий и их чувствительность к адреналину при адаптации к холоду. В работе показано, что после 10 дней холода возросла прессорная реакция артерий на все 8 доз адреналина за счет увеличения количества активных адренорецепторов артерий на 32% и увеличения чувствительности адренорецепторов к адреналину на 50%.

Adaptation of the body to cold requires a multifaceted restructuring of the work of many functional systems of the body. A special role in adaptation to cold is played by the sympathetic nervous system and its neurotransmitters norepinephrine and adrenaline. In our work, we studied the receptor mechanisms of regulation of the tone of the arteries of the rabbit extremity to the neurotransmitter adrenaline during 10 days of cold adaptation. Pharmacokinetic and pharmacodynamic changes in the reactivity of arterial alpha-adrenergic receptors to adrenaline were studied by the Lineyover-Burk and Sketchard method. This made it possible to determine the number of active a-adrenergic receptors in the arteries and their sensitivity to adrenaline during adaptation to cold. The work shows that after 10 days of cold, the pressor response of the arteries to all 8 doses of adrenaline increased due to an increase in the number of active arterial adrenoreceptors by 32% and an increase in the sensitivity of adrenoreceptors to adrenaline by 50%.
IN VITRO CULTIVATION OF REPRESENTATIVES OF THE GENUS NEPETA L.
Authors: Зиновьева О.Д. , Чередниченко М.Ю.
Published: May 2023

Род Nepeta L. (котовник) относится к семейству Lamiaceae Martinov (яснотковые) и наряду с другими представителями данного семейства обладает лекарственными свойствами. В частности, в народной медицине его применяют в качестве жаропонижающего, противовоспалительного, общеукрепляющего средства, против мигрени и меланхолии, высыпаний на коже, при анемии и бронхите. Помимо медицины котовник находит применение в косметической и парфюмерной промышленности, в кулинарии и ландшафтном дизайне. Котовник содержит много полезных веществ, таких как розмариновая кислота, аскорбиновая кислота, дубильные вещества, микроэлементы, витамин C, эфирные масла, гликозиды, фенольные соединения. Культивирование растений рода котовник in vitro позволяет лучше изучить свойства содержащихся в них веществ и процессов их накопления, а также процессы каллусогенеза и морфогенеза. В статье представлены некоторые из исследований, проводимых в данной области.

The genus Nepeta L. (catnip) belongs to the family Lamiaceae Martinov (mint family) and, along with other representatives of this family, has medicinal properties. In particular, in folk medicine it is used as an antipyretic, anti-inflammatory, tonic agent, against migraine and melancholy, skin rashes, anemia and bronchitis. In addition to medicine, catnip is used in the cosmetic and perfume industries, in cooking and landscape design. Catnip contains many useful substances, such as rosmarinic acid, ascorbic acid, tannins, microelements, vitamin C, essential oils, glycosides, phenolic compounds. Cultivation of catnip plants in vitro makes it possible to better study the properties of the substances contained in them and the processes of their accumulation, as well as the processes of callusogenesis and morphogenesis. The article presents some of the research conducted in this area.
PRINCIPLES OF EARLY DIAGNOSIS OF NEURODEGENERATIVE DISEASES
Authors: Никитина В.В. , Смочилин А.Г.
Published: May 2023

Известно, что основной проблемой диагностики нейродегенеративных заболеваний является выявление нейронных повреждений на начальных стадиях их развития. Для дегенеративных заболеваний нервной системы характерны недвигательных проявления в виде эмоционально-волевых, когнитивных нарушений, ухудшения сна, обоняния, глазодвигательных расстройств, координации движений, функций тазовых органов, эректильных дисфункций, ангидроза. Цель: улучшить диагностику, терапию больных с нейродегенеративными заболеваниями. В статье были изложены приоритетные разработки современной неврологии по ранней диагностики, терапии дегенеративных заболеваний нервной системы. В настоящее время выявление неврологических, лабораторных, нейрофизиологических и нейровизуализационных изменений способствует ранней верификации нейродегенеративных заболеваний. Применение персонифицированных лечебных комплексов способствует улучшению качества и продолжительности жизни больных.

It is known that the main problem in the diagnosis of neurodegenerative diseases is the detection of neural damage at the initial stages of their development. Degenerative diseases of the nervous system are characterized by non-motor manifestations in the form of emotional-volitional, cognitive disorders, deterioration on sleep, sense of smell, oculomotor disorders, coordination of moments, pelvic organ functions, erectile dysfunction, anhidrosis. Objective: to improve the diagnosis and therapy of patients with neurodegenerative diseases. The article outlines the priority developments of modern neurology for early diagnosis, therapy of degenerative diseases of nervous systems. Currently, the detection of neurological, laboratory, neurophysiological and neuroimaging changes contributes to the early verification of neurodegenerative diseases. The use of personalized medical medical complexes contributes to improving the quality and life expectancy of patients.
THE INFLUENCE OF HEALTH RISK FACTORS ON THE QUALITY OF LIFE OF THE POPULATION OF PRIMORSKY KRAI IN THE CONTEXT OF THE COVID-19 PANDEMIC
Authors: Изергина Е.В.
Published: May 2023

Общественное здоровье обеспечивает качество жизни населения. Здоровый образ жизни – один из факторов, влияющих на качество жизни. Первичная профилактика неинфекционных заболеваний включает коррекцию поведенческих факторов. Это предотвратимые факторы, связанные с образом жизни населения – питание, двигательная активность, минимизация вредных привычек, способность адаптироваться к жизненным ситуациям и негативным изменениям. Проведено исследование влияния поведенческих факторов среди муниципальных образований Приморского края и оценено их влияние как на неинфекционную заболеваемость, так и на заболеваемость Covid-19. Выявлено, что очень высокий уровень заболеваемости Cоvid-19 (в 5 раз выше среднего по Приморскому краю) наблюдался в городе Дальнереченске, где имеются три неинфекционные нозологии (болезни системы кровообращения, эндокринные заболевания, хронический алкоголизм) с превышением среднего уровня по региону в 2-3 раза. Из других районов с превышением уровня заболеваемости Covid-19 в полтора – два раза можно выделить Лазовский район (первичная заболеваемость по нозологии «болезни системы кровообращения» в 5 раз выше средних значений по Приморскому краю), Черниговский район (первичная заболеваемость по нозологии «болезни эндокринной системы» в 5 раз выше средних значений по Приморскому краю).

When correlating the levels of non-communicable morbidity (diseases of the cardiovascular system, endocrine morbidity, chronic alcoholism), it was revealed that a very high incidence of Covid-19 (5 times higher than the average in Primorsky Krai) was detected in the city of Dalnerechensk, where all three non-communicable nosologies are present with an excess of the average level in the region by 2-3 times. From other areas with an excess of the incidence of Covid-19 by one and a half to two times, Lazovsky district can be distinguished (the primary incidence of nosology «diseases of the circulatory system» is 5 times higher than the average values for Primorsky Krai), Chernihiv district (the primary incidence of nosology «diseases of the endocrine system» is 5 times higher than the average values for Primorsky Krai edge).
ASSESSMENT OF THE ATMOSPHERIC AIR OF PUBLIC GREEN SPACES IN SEVASTOPOL BY THE METHOD OF EXPRESS ASSESSMENT OF DENDROFORMS
Authors: Косовская М.А. , Лямина Н.В.
Published: May 2023

В статье представлены результаты апробации разработанной методики экспресс-оценки дентроформ методом биоиндикации. Оценка состояния атмосферного воздуха проводилась на территории ЗНОП (зеленые насаждения общего пользования) г.Севастополя.

The article presents the results of approbation of the developed methodology for rapid assessment of dentroforms by the bioindication method. The assessment of the state of atmospheric air was carried out on the territory of the ZNOP (public green spaces) of the city of Sevastopol.
Die museale Hängung der „Kreuzigung Christi“ von Lucas Cranach dem Älteren im Kontext
Authors: Dollmann Jürgen W. , Okropiridze Dimitry
Published: May 2023

Wie Bilder in Museen wahrgenommen werden, ist geprägt von der Präsentation im Raum, vor allem durch den Kontext im Zusammenhang mit anderen Bildern. Die Augen der Betrachter:innen können mehr oder weniger gezielt im Durchschreiten des musealen Raumes gelenkt werden. Dadurch kommt es zu Narrativen im Bewusstsein, welche je nach Vorprägungen oder Vorinformationen individuell ausfallen. Im folgenden Text wird die Wahrnehmung der „Kreuzigung Christi“ von Lucas Cranach dem Älteren im Städel Museum Frankfurt im Kontext zur unmittelbar daneben präsentierten „Venus“ desselben Künstlers analysiert. Dazu werden semiotische Methoden neben spezifischen kunsttheoretischen Ansätzen zum Bild im Plural herangezogen. Der Text bettet die Wahrnehmungsanalyse der besprochenen Bilder in eine Diskussion des Museums als außerschulischem Lernort ein.
Chiral Selective Self-Replicators
Authors: Yang Shuo , Geiger Yannick , Geerts Marc , Eleveld Marcel J. , Kiani Armin , Otto Sijbren
Published: May 2023

Self-replicating molecules provide a simple approach for investigating fundamental processes in scenarios of the emergence of life. Although homochirality is an important aspect of life and of how it emerged, the effects of chirality on self-replicators have received only little attention so far. Here we report several self-assembled self-replicators with chiral selectivity, that emerge spontaneously and grow only from enantiopure material. These require a relatively small number of chiral units in the replicators (down to 8) and in the precursors (down to a single chiral unit), compared to the only other chiral selective replicator reported previously. One replicator was found to incorporate material of its own handedness with high fidelity when provided with a racemic mixture of precursors, thus sorting (L)- and (D)-precursors into (L)- and (D)-replicators. Systematic studies reveal that the presence or absence of chiral selectivity depends on structural features (ring size of the replicator) that appear to impose constraints on its supramolecular organization. This work reveals new aspects of the little researched interplay between chirality and self-replication and represents another step towards the de novo synthesis of life.
Non-isothermal Chemical Vapor Deposition for Increasing Carbon Nanotube Yield
Authors: Rao Rahul , Carpena-Nunez Jennifer , Maruyama Benji
Published: May 2023

Increasing the yield of single-walled carbon nanotubes (CNTs) during growth is critical to their use in widespread applications. Here, we show that we can increase the CNT yield significantly by using a simple non-isothermal, continuous cooling procedure during CNT growth. While our typical isothermal growth conditions produce sparse bundled mats, our non-isothermal growth protocol results in high-density tall forests without the need for growth promoters, additional source materials, or additional processing. In situ experiments revealed that cooling rate and temperature difference are critical and were optimized for the highest increase in CNT yield. Moreover, the general applicability of the process was demonstrated by performing chemical vapor deposition growth experiments in a tube furnace on a variety of catalyst compositions and thicknesses. The observed improvement in the non-isothermal process across all experimental platforms and catalysts occurs due to a decline in particle coarsening and to the formation of smaller particles with an order of magnitude higher density compared to isothermal growth. We 1 attribute this to the de-stabilization of the catalyst films during continuous cooling. Non- isothermal growth provides a path forward for improving SWCNT yields while retaining all other growth conditions.
Towards multi-scale measurement-informed methane inventories: reconciling bottom-up site-level inventories with top-down measurements using continuous monitoring systems
Authors: Daniels William , Wang Jiayang (Lyra) , Ravikumar Arvind , Harrison Matthew , Roman-White Selina , George Fiji , Hammerling Dorit
Published: May 2023

Government policies and corporate strategies aimed at reducing methane emissions from the oil and gas sector increasingly rely on measurement-informed emissions inventories, as conventional bottom-up inventories poorly capture temporal variability and the heavy-tailed nature of methane emissions. This work is based on an 11-month methane measurement campaign at oil and gas production sites. We find that operator-level top-down methane measurements are lower during the end-of-project phase than during the baseline phase. However, gaps persist between end-of-project top-down measurements and bottom-up inventories, which we reconcile with high-frequency data from continuous monitoring systems (CMS). Specifically, we use CMS to (i) validate specific snapshot measurements and determine how they relate to the temporal emissions profile of a given site and (ii) create a measurement-informed, site-level inventory that can be validated with top-down measurements to update conventional bottom-up inventories. This work presents a real-world demonstration of how to reconcile CMS rate estimates and top-down snapshot measurements jointly with bottom-up inventories at the site-level. More broadly, it demonstrates the importance of multi-scale measurements when creating measurement-informed emissions inventories, which is a critical aspect of recent regulatory requirements in the Inflation Reduction Act, voluntary methane initiatives such as OGMP 2.0, and corporate strategies.
A Hierarchy of Ligands Controls Formation of Aryl Radicals in Pd-Catalyzed Ground State Reactions
Authors: Clark Kenneth , Evans Laura , Murphy John
Published: May 2023

Palladium salts and complexes were tested separately and in the presence of added ligands, as potential sources of aryl radicals in ground state coupling reactions of aryl halide with arenes under basic conditions (KOtBu). Our recently developed assay for aryl radicals was employed to test for aryl radicals. In this assay, aryl radicals derived from the test substrate, 1-iodo-2,6-dimethylbenzene 7, undergo base-induced homolytic aromatic substitution (BHAS) with benzene to produce 2,6-dimethylbiphenyl 8, and biphenyl 9, in an approx. 1:4 ratio as well as m-xylene 10. The biphenyl arises from a diagnostic radical transfer reaction with the solvent benzene. Using substrate 7 with a range of Pd sources as potential initiators led to formation of 8, 9, 10 in varying amounts. However, when any one of a range of diphosphinoferrocenes (e.g dppf or dippf) or BINAP (20 mol% in each case) was added as a ligand to Pd(OAc)2, the ratio of [2,6-dimethylbiphenyl 8: biphenyl 9] moved decisively to that expected from the BHAS (radical) pathway. Further studies were conducted with dppf. When dppf was added to each of the other Pd sources, the ratio of coupled products was also diverted to that expected for radical BHAS chemistry. Deuterium isotope studies and radical trap experiments provide strong additional support for the involvement of aryl radicals. Accordingly, under these ground state conditions, palladium sources in the presence of defined ligands, convert aryl iodides to aryl radicals.
Regioselective Direct C−H Bond (Hetero)arylation of Thiazoles Enabled by a Novel Iminopyridine-Based α‐Diimine Nickel(II) Complex Evaluated by DFT Studies.
Authors: Chatterjee Shubham , Damien E. Arche Phillip , Talukder Md Muktadir , T. Miller Justin , Michael O. Cue John , M. Udamulle Gedara Chinthaka , Lord Richard , C. Biewer Michael , Cisneros G. Andrés , C. Stefan Mihaela
Published: May 2023

Direct C−H bond arylation is a highly effective method for synthesizing arylated heteroaromatics. This method reduces synthetic steps and minimizes the formation of impurities. We report an air and moisture-stable iminopyridine-based α-diimine nickel (II) complex for direct C5-H bond arylation of thiazole derivatives. Under low catalyst loading and performing the reactions at lower temperatures (80 °C) under aerobic conditions, we produced mono- and diarylated thiazole units. Competition experiments and density functional theory calculations (DFT) revealed that the mechanism of C−H activation in 4-methylthiazole involves electrophilic aromatic substitution.
Kinetics-Constrained Neural Ordinary Differential Equations: Artificial Neural Network Models tailored for Small Data to boost Kinetic Model Development
Authors: Fedorov Aleksandr , Perechodjuk Anna , Linke David
Published: May 2023

Artificial neural networks (ANNs) are powerful tools for solving a wide range of tasks in fundamental and applied science. However, training and building reliable ANN models requires a lot of data which so far hinders their wider application in kinetic modelling where typically only small (experimental) datasets are available. In the present work we propose a method to design ANN models for kinetic modelling that can be trained even with small data sets as are typically available. The key idea is to constrain the architecture of the ANN models by integrating kinetic and thermodynamic knowledge leading to what we call Kinetics-Constrained Neural Ordinary Differential Equations (KCNODE). The feasibility and effectiveness of the approach is first demonstrated in a numerical experiment using the catalytic hydrogenation of CO2 to methane as example. Next, we demonstrate the approach for real experimental data of a more complex reaction, the hydrogenation of CO2 to higher hydrocarbons (CO2-FT). Finally, the ANN trained for CO2-FT is used to derive an improved mechanistic model for the reverse water gas shift reaction which is a key reaction in the CO2-FT reaction network. This last step exemplifies how the opportunity to obtain reliable ANN models from small data opens new ways to approach kinetic model development.
Integrated Optics Polarized Light and Evanescent Wave Surface-Enhanced Raman Scattering to detect ligand Interactions at nanoparticle surfaces
Authors: Chen Xining , Andrews Mark
Published: May 2023

The orientation of sensing molecules on the surface of biosensors is crucial for effective interaction with target analytes, and Raman spectroscopy is a versatile and non-invasive technique used to study molecular configurations at the sub-nanoscale level. This study explores the sensing abilities of an integrated optics construct called an Optical Chemical Bench (OCB) for the detection of molecular orientation, ion binding, and nanoparticle binding. The OCB consists of plasmonic gold-silver nanoparticles bound to the surface of a multimode slab waveguide. This design offers controlled plasmonic excitation in both position and polarization, increasing the interfacial mean square electric field relative to the incident field, and allowing for polarization-dependent surface-enhanced Raman scattering (SERS) on a chip. The experiments gave insight into how the TE and TM polarization modes interact with adsorbates that are built up as hierarchical structures on the OCB, providing an inexpensive yet effective molecular probing technology at the interface.
The role of artificial intelligence in cardio-oncology: present and future: A review
Authors: Buziashvili Yuri I. , Asymbekova Elmira U. , Tugeeva Elvina F. , Akildzhonov Firdavsdzhon R.
Published: May 2023

Cardiooncology has been developed as a relatively new branch of medicine that focuses on the prevention and treatment of adverse cardiovascular events associated with cancer therapy. Newer, more efficient data acquisition methods, such as the use of artificial intelligence, are desirable to help assess CVR in cancer patients. By extracting hidden patterns and evidence from large volumes of medical data, artificial intelligence can create new predictors and parameters to predict risks in patients with cardio-oncological diseases.
Effectiveness and safety of the herbal preparation Soveren® in patients with hyperuricemia
Authors: Gromova Margarita A. , Tsurko Vladimir V.
Published: May 2023

Background. Despite advances in the field of synthetic pharmaceuticals, interest in the use of natural raw materials from representatives of the flora persists throughout the world. Currently, herbal medicine is successfully used in the treatment of both hyperuricemia (HU) and gout.
Aim. To evaluate the effectiveness and safety of the herbal preparation Soveren in the prevention and treatment of HU.
Materials and methods. The study included 80 patients who were divided into 2 groups: group 1 consisted of patients diagnosed with arthritis with HU (n=40), group 2 patients with gout (n=40). The natural complex of natural origin Soveren was prescribed according to the standard scheme against the background of dietary recommendations. Patients with gout also received urate-lowering therapy. Clinical efficacy and safety of treatment were assessed after 6 and 12 weeks according to the dynamics of laboratory parameters of blood and urine, the EuroQol-5D quality of life questionnaire, assessment of the health status of patients, assessment of patient satisfaction with treatment.
Results. The use of the plant complex Soveren in patients with HU does not have a negative effect on the functional state of the liver and kidneys. The drug has a significant positive effect on blood levels, reducing uric acid by 1.5 times, creatinine by 1.11 times, and urea by 1.3 times. In group 2, the addition of the Soveren complex made it possible to achieve the target value of uric acid. In addition, in patients of both groups, within 3 months, the level of total protein in the urine decreased by 3 times, a decrease in the degree of leukocyturia was noted. Against the background of taking the drug in both groups, the relative density of urine increases within the normal range, and a slight acidification of urine was revealed, as well as an increase in urinary excretion of ketones. Most patients positively assessed the result of treatment.
Conclusion. Our data confirm the good therapeutic effect and safety of the herbal complex Soveren in patients with HU. With the introduction of the Soveren drug into practice, doctors will have a new effective tool for monitoring the course of HU.
The state of systolic and diastolic myocardial functions in patients with severe obstructive sleep apnea and their dynamics during CPAP therapy
Authors: Kuchmin Alexey N. , Ekimov Vitaliy V. , Kazachenko Alexandr A. , Nagornyy Mikhail B. , Galova Elena P. , Evsyukov Konstantin B. , Pukhova Uliana D.
Published: May 2023

Aim. To evaluate the change in the parameters of systolic and diastolic myocardial functions in patients with severe obstructive sleep apnea (OSA) syndrome before and after CPAP therapy.
Materials and methods. Forty eight patients with severe OSA aged 4574 years were examined. All patients underwent questionnaires, echocardiography with tissue Dopplerography, speckle-tracking echocardiography. At the end of the three-month course of CPAP therapy, the patients were re-examined, followed by a comparative analysis of the data obtained.
Results. In patients with severe OSA after CPAP therapy, the ejection fraction of the left ventricle and the amplitude of systolic displacement of the fibrous ring of the tricuspid valve significantly increased, which indicated an increase in the relative capacity of the ventricular myocardium. The performed CPAP therapy had a positive effect on the diastolic function of the myocardium of both ventricles, which was manifested in an increase in the ratio of peak rates of early and late transmitral and transtricuspidal diastolic flows. The rate of transtricuspidal regurgitation and systolic pressure in the pulmonary artery decreased in dynamics.
Conclusion. The use of CPAP therapy improves systolic and diastolic heart function, leads to a decrease in systolic pressure in the pulmonary artery in patients with severe OSA. The results obtained substantiate the importance of early initiation of CPAP therapy in the complex treatment of patients with OSA.
The effect of sex on the normal functioning of the prostate gland: A review
Authors: Ershov Anton V. , Saverskaya Elena N.
Published: May 2023

This article analyzed the relationship between sexual activity and the structural and functional state of the prostate gland. The biomechanism of hormonal effects during sexual activity was evaluated. The influence of hormones on the functioning of the prostate gland was analyzed. It has been established that constant sexual activity in moderate amounts reduces the risk of developing prostate diseases and is an important method of prevention. To correct copulative function disorders in diseases of the prostate gland, it is advisable to use prostatic peptides that have an organotropic effect.
CNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1
Authors: He Jinghu , Yang Xiaohong , Zhang Chuansen , Li Ang , Wang Wei , Xing Junjie , E Jifu , Xu Xiaodong , Wang Hao , Yu Enda , Shi Debing , Wang Hantao
Published: May 2023

Colorectal cancer (CRC) is one of the most commonly diagnosed malignant tumors of the digestive tract. H2-calponin (CNN2), an actin cytoskeleton-binding protein, is an isoform of the calponin protein family whose role in CRC is still unknown. Research based on clinical samples showed the up-regulation of CNN2 in CRC and its association with tumor development, metastasis, and poor prognosis of patients. Both in vitro loss-of-function and gain-of-function experiments showed that CNN2 participates in CRC development through influencing malignant cell phenotypes. In vivo, xenografts formed by CNN2 knockdown cells also showed a slower growth rate and smaller final tumors. Furthermore, EGR1 was identified as a downstream of CNN2, forming a complex with CNN2 and YAP1 and playing an essential role in the CNN2-induced regulation of CRC development. Mechanistically, CNN2 knockdown down-regulated EGR1 expression through enhancing its ubiquitination, thus decreasing its protein stability in a YAP1-dependent manner. In summary, CNN2 plays an EGR1-dependent promotion role in the development and progression of CRC, which may be a promising therapeutic target for CRC treatment.
TECHNOLOGIES FOR RESOLVING NETWORK CONFLICTS
Authors: Bankouskaya Yulia
Published: May 2023

The study and understanding of modern technological processes, occurring in society, ambivalent nature leads to the need to clarify network processes. Social networks gradually become not only a theoretical construct, but also an empirical object included in the sphere of human daily life. Uncontrollability, anonymity, lack of unified value orientations and a strict system of control over the transmission of information, multi-channel, hypertextuality, and interactivity inherent in network interaction make it difficult to resolve conflicts. In order to reduce the level of acute contradictions, the main measures regulating people's activities within the information and communication space should be taken. The study of social capital as a basic phenomenon that determines the specifics of the network structures interaction is caused by the fact that this capital is a resource that has a direct impact on the quality of the network, its functioning and development. The mechanisms of its distribution are used to build attitudes, activities, and a model of people's behavior in network foundation. It acts as an information resource that affects the causes of conflict, the specifics of its unfolding, and the development of measures to resolve contradictions. The study of social capital allows us to clarify the features of network conflicts that consist in their anonymity, openness, sensory distancing, lack of sanctions and legal consequences for violation of social norms. Symbolic information space in this case acts as the main sphere of unfolding the confrontation. The importance of network conflict resolution establishes controlling over the conflict situation and developing measures to resolve it, searching for means and ways to achieve the desired result, and elaboration options for preventing the negative productivity of the problem, preventing the escalation of violence and destruction of the existing forms of social system functioning. It contributes to its transformation into more humane relationships of people to each other, interests and changes in life aspirations.
Relative age effect in young competitive tennis players
Authors: Söğüt Mustafa , Biber Koray , Ödemiş Hasan , Durmuş Durukan , Ulusoy İsmet Tarık
Published: May 2023

The purpose of this study was to examine the presence of the relative age effect (RAE) in young tennis players. Data from a sample of all ranked (n= 3463) and licensed (n= 29150) players in consecutive age groups (10- to 17-year-old) were collected from the official web page of the national federation. They were assigned to four quartiles according to the month of birth: a) Quartile 1 = January-February-March, b) Quartile 2 = April-May-June, c) Quartile 3 = July-August-September, d) Quartile 4 = October-November-December. The players aged between 10 and 17 years affiliated with the national federation were assigned as theoretically expected distribution. The results revealed that 70%, 60.1%, and 56.6% of the top 10, 50, and all ranked players were born in the first half of the year, respectively. However, the results from the chi-square test of goodness-of-fit showed significant RAEs only in the distributions of all ranked and top 50 players at the age of 10 and 11 correspondingly. These results may suggest that RAE exists among young tennis players who are in their early adolescence years.
Properties of some nonlinear partial dynamic equations on time scales
Authors: Deepak B. Pachpatte
Published: May 2023

The aim of the present paper is to study some basic qualitative properties of solutions of certain nonlinear partial dynamic equations on time scales. The tools employed are application of Banach fixed point theorem and a variant of certain fundamental integral inequality with explicit estimates on time scales.
Embedding in distance degree regular and distance degree injective graphs
Authors: Medha Itagi Huilgol  , M. Rajeshwari  , S. Syed Asif Ulla
Published: May 2023

The eccentricity $e(u)$ of a vertex $u$ is the maximum distance of $u$ to any other vertex of $G$.The distance degree sequence (dds) of a vertex $u$ in a graph $G=(V, E)$ is a list of the number of vertices at distance $1,2, \ldots$, $e(u)$ in that order, where $e(u)$ denotes the eccentricity of $u$ in $G$. Thus the sequence $\left(d_{i_0}, d_{i_1}, d_{i_2}, \ldots, d_{i_j}, \ldots\right)$ is the dds of the vertex $v_i$ in $G$ where $d_{i_j}$ denotes number of vertices at distance $j$ from $v_i$. A graph is distance degree regular (DDR) graph if all vertices have the same dds. A graph is distance degree injective (DDI) graph if no two vertices have the same dds.

In this paper, we consider the construction of a DDR graph having any given graph $G$ as its induced subgraph. Also we consider construction of some special class of DDI graphs.
Peristaltic pumping of a Jeffrey fluid in an asymmetric channel with permeable walls
Authors: Y. V. Ravi Kumar  , S. Rajender  , S. V. H. N. P. Krishna Kumari  , S. Sreenadh
Published: May 2023

This paper deals with the peristaltic pumping of a Jeffrey fluid in an asymmetric channel with permeable walls under long wave length and low Reynolds number assumptions. The channel asymmetry is produced by choosing the peristaltic wave trains with phase difference on the walls of the channel. The flow is investigated in a wave frame of reference with the velocity of the wave. The effect of various parameters on the flow characteristics are discussed through graphs.
UM CONTRASTE ENTRE DECISÕES CONTRA LEGEM E AS TÉCNICAS DE SUPERAÇÃO DE PRECEDENTES
Authors: Faggion Vinicius De Souza
Published: May 2023

Neste artigo apresento um contraste entre a possibilidade prática e moral de decisões judiciais contra legem de um lado e, do outro, de decisões judiciais baseadas em precedentes e superadas pelas técnicas do distinguishing e do overruling. Através da análise de caso cuja aplicação do precedente prevalece, e de exemplos reais e hipotéticos, meu objetivo é demonstrar que decisões contra legem propriamente entendidas implicam vereditos não só contrários a autoridade de precedentes em força, mas são desvios ao direito diversos das técnicas de superação dos precedentes já mencionadas. Desse modo, não apenas contrariam a literalidade de regras jurídicas, mas têm o potencial de razoavelmente contrariar a autoridade institucional do direito. Também sugiro que, se o contraste for correto e instancias de decisões contra legem forem moralmente permissíveis, será necessário discutir com maior cuidado o conjunto das obrigações que juízes têm sobre a aplicação do direito.
A PARTICIPAÇÃO DA COMUNIDADE NO MÉTODO APAC : UMA FERRAMENTA DE EFETIVIDADE DA LEI DE EXECUÇÃO PENAL
Authors: Pozzoli Lafayette , Costa Ilton Garcia da , Cachichi Rogério Cangussu Dantas , Siqueira Gilmar Assis
Published: May 2023

O objetivo deste artigo é fazer uma leitura do método APAC a partir da participação da comunidade. Tal método de cumprimento de sentença humanizado conta com doze fundamentos que encontram confirmação na Lei de Execução Penal vigente. O primeiro desses fundamentos é a participação da comunidade, imprescindível para a aplicação do método APAC. Esse fundamento será analisado desde a perspectiva do comunitarismo a fim de demonstrar que o contato do preso com a própria comunidade de origem tem benefícios tanto para ele (no estímulo às virtudes a partir da dignidade humana) quanto para a sua comunidade (que o receberá após o cumprimento da pena). A pesquisa foi desenvolvida utilizando o método de abordagem hipotético-dedutivo, o procedimento comparativo, a técnica de documentação indireta, a pesquisa bibliográfica: em livros e periódicos jurídicos; documental; em legislação e em sites eletrônicos.
INFRAÇÕES TRIBUTÁRIAS - FRAUDE FISCAL -, BRANQUEAMENTO/LAVAGEM DE VANTAGENS (CAPITAIS) E FINANCIAMENTO DO TERRORISMO: PORTUGAL E UNIÃO EUROPEIA
Authors: Bandeira Gonçalo S. de Melo , Azevedo Patrícia Anjos
Published: May 2023

existe uma ligação muito próxima entre o crime de fraude fiscal e o crime de branqueamento por exemplo de capitais. Desde logo o crime de fraude fiscal é um crime e/ou ilícito primário que pode dar origem ao crime secundário de branqueamento por exemplo de capitais. Também nos casos reais relacionados com a corrupção em sentido amplo que têm vindo a público por intermédio da comunicação social são os crimes de fraude fiscal e branqueamento de capitais, crimes irmãos praticamente inseparáveis. Normalmente um anda associado ao outro. Depois de se cometer o crime de fraude fiscal é necessário branquear/lavar o dinheiro e/ou vantagens adquiridas. Ora, também é consabido internacionalmente que o terrorismo anda associado aos ilícitos anteriores devido à sua forte necessidade de financiamento. Tanto maior quanto mais sofisticada for a preparação dos atentados terroristas. Muitas vezes verdadeiros actos de declaração de guerra. Como prevenir isto? Desde logo dando formação e educação às pessoas e repartindo melhor a riqueza entre as pessoas: art. 103º da Constituição da República Portuguesa.
MULTICULTURALISMO, DELITOS CULTURALMENTE MOTIVADOS E VIOLÊNCIA CONTRA A MULHER: PERSPECTIVAS ESPANHOLA E BRASILEIRA
Authors: Sarmento Lins Júnior George , Lessa Ramos Galvão Gabriela
Published: May 2023

O presente artigo busca investigar o multiculturalismo, enquanto ideal de respeito mútuo entre as identidades culturais, intrinsecamente conectado à globalização. Analisa-se a sensível relação entre multiculturalismo e direitos humanos e como os Estados devem compatibilizar, de um lado, a enriquecedora diversidade cultural, e, de outro, o respeito aos direitos humanos universais. Em especial, examina-se como Espanha e Brasil têm enfrentado a problemática multiculturalista, notadamente no tocante aos delitos culturalmente motivados. Ademais, observa-se a delicada relação entre multiculturalismo e feminismo e a necessidade de equilibrar o direito à cultura e os direitos das mulheres à igualdade e liberdade, tendo em vista que a subordinação da mulher ao homem corresponde a uma construção cultural, comum a praticamente todos os países.
COMPREENDENDO A MUDANÇA DA JURISPRUDÊNCIA DO STJ SOBRE PRESCRIÇÃO TRIBUTÁRIA: DO DIREITO LEGISLADO PARA O DIREITO DO GRUPO SOCIAL
Authors: Becho Renato Lopes
Published: May 2023

O objetivo deste artigo é buscar compreender o que levou o Superior Tribunal de Justiça a não mais aplicar o estabelecido na Constituição Federal, que determina que cabe à lei complementar (i.e., ao Código Tributário Nacional) disciplinar a interrupção da prescrição do crédito tributário em relação à execução fiscal, e passar a aplicar, parcialmente, o Código de Processo Civil. A aplicação parcial da lei foi um movimento retórico, significando, em realidade, um afastamento do positivismo jurídico pela jurisprudência, sem fundamentação convincente. Em vista dessa conclusão parcial, o autor propõe levar em consideração, como um dos caminhos possíveis para a compreensão do ocorrido, a Sociologia Jurídica de Eugen Ehrlich. Para tanto, contrastou a mudança jurisprudencial com duas visões antagônicas do direito, que ficaram bem claras no debate entre Ehrlich e Hans Kelsen, para sustentar a hipótese de que a Corte se afastou do direito legislado, passando a aplicar um direito do grupo social (no caso, do próprio Tribunal).
DEFESA DO CONSUMIDOR EM PERSPECTIVA COMPARADA A PARTIR DO SISTEMA DOS PAÍSES DO MERCOSUL
Authors: De Andrade Fabio Siebeneichler , Vidaletti Leiliane Piovesani
Published: May 2023

O artigo pretende analisar, à luz do direito comparado, relativamente aos países do Mercosul, o grau de proteção ao consumidor, especialmente no que se refere à temática da tutela contratual. Considerando o extraordinário desenvolvimento da globalização e o incremento significativo das relações de consumo entre países, mediante o exame de variáveis pré-definidas, constata-se um elevado nível protetivo da normativa brasileira, bem como a necessária harmonização da legislação consumerista entre os países que compõem o bloco, a fim de resguardar os legítimos interesses dos consumidores. A pesquisa se desenvolve, por fim, pelos métodos indutivo (de abordagem), comparativo (de procedimento) e sistemático (de interpretação jurídica), tendo cunho teórico e, quanto aos objetivos, classificando-se como eminentemente descritiva e explicativa.
O PROCESSO CONSTITUCIONAL E O DEVIDO PROCESSO LEGAL COMO FUNDAMENTO DA LEGITIMIDADE DEMOCRÁTICA DOS ATOS LEGISLATIVOS E JURISDICIONAIS
Authors: Diz Jamile Bergamaschine Mata , Gonçalves Gomes Reginaldo , Simoes de Tomáz Carlos Alberto
Published: May 2023

A partir de uma abordagem lógico-dedutiva e tendo como referencial o historicismo político-jurídico de Nicola Matteucci, o artigo alavanca a legitimidade dos atos legislativos e jurisdicionais a partir de uma conformação não apenas formal, mas principalmente material, do processo constitucional e do devido processo legal, que para além da motivação exclusivamente patrimonial que lhes impregnou a origem na experiência constitucional inglesa, encontram-se alçados a pavimentar o caminho da experiência democrática em defesa da efetividade dos direitos fundamentais, circunstância que resulta no fortalecimento do devido processo legal.
INOVAÇÃO NA NOVA LEI DE LICITAÇÃO: DIRETRIZ E POTENCIAL DE MODERNIZAÇÃO PELO ESTADO
Authors: Nohara Irene Patrícia
Published: May 2023

O presente artigo pretende analisar a inovação sob a égide da nova lei de licitações para apontá-la como diretriz e potencial de modernização do Estado em suas compras. Com amparo no método hipotético-dedutivo e de referencias teóricos do Estado Empreendedor, procurar-se-á desmistificar a imagem do senso comum no sentido de que o mercado se auto-inova, lançando luz sobre o papel do Estado na formação e na criação dos novos mercados. Assim, serão enfatizados os objetivos meta-contratuais de desenvolvimento nacional sustentável e de inovação pela licitação, sendo, na sequência, abordado o compliance enquanto fator indutor de comportamentos de integridade do mercado fornecedor do Estado. Há, ainda, o desdobramento do diálogo competitivo, na comparação com o procedimento de manifestação de interesse e da encomenda tecnológica, enquanto nova modalidade, sendo analisada sua aptidão para estimular um mercado fornecedor de produtos e serviços inovadores. Por fim, aponta-se quais são os grandes potenciais de inovação nas licitações, com foco no credenciamento de mercados flutuantes, e se adverte para a necessidade de se deixar de lado um olhar retrospectivo da nova lei, dado que a visão prospectiva representa a condição para sua utilização com o escopo de modernizar as práticas licitatórias e as contratações públicas do Estado.
ECONOMIA COMPARTILHADA E USO RACIONAL E SUSTENTÁVEL DOS BENS DE CONSUMO
Authors: Santin Janaína Rigo , Magalhães João Marcelo Rego
Published: May 2023

Ainda que não seja um modelo econômico novo, o compartilhamento de bens e serviços alçou escala nunca vista nos últimos anos graças à revolução digital e à multiplicação de plataformas, as quais se dedicam a aproximar fornecedores e consumidores. Este estudo, por meio do método dedutivo, visa analisar a economia do compartilhamento e seu tratamento jurídico, destacando a cisão da economia tradicional de hiperconsumo para relações consumeristas mais sustentáveis, com a utilização racional e eficiente de bens ociosos, os quais passam a ser compartilhados por meio de plataformas digitais. Dessa forma, problematiza-se a questão da (des) regulação das relações que surgem entre as plataformas de compartilhamento e seus prestadores de serviços associados, bem como dentre aquelas e os usuários desses bens e serviços.
A PRÁTICA DO BOM PROFESSOR: AS CONTRIBUIÇÕES DE GALUPPO PARA A METODOLOGIA DO ENSINO SUPERIOR
Authors: Medrado Vitor Amaral , Grillo Fernanda Fontenelle
Published: May 2023

O texto é resenha do livro Introdução à vida acadêmica II: manual do professor – um guia de metodologia do ensino para professores de cursos superiores, de Marcelo Campos Galuppo (São Paulo, Dialética, 2022). O objetivo é mostrar como o livro contribui para minimizar a formação deficitária dos professores de ensino superior em metodologia do ensino ocasionada pela lacuna de oferta de disciplinas e conteúdos voltados para tal nos programas de pós-graduação stricto sensu no Brasil.
DERECHO Y DEMOCRACIA EN LA PERIFERIA DE LA SOCIEDAD MODERNA. ESTRUCTURAS, SEMÁNTICAS Y EXPECTATIVAS
Authors: Farías Raúl Zamorano
Published: May 2023

Sobre la base de la arquitectura conceptual de la Teoría General de los Sistemas Sociales (TGSS), se problematiza el problema del orden jurídico–político en la periferia de la sociedad moderna, rastreando las formas de institucionalización de las estructuras, semánticas y expectativas y los artefactos que se reproducen y parasitan en esas estructuras con las cuales, paradójicamente, se construye el orden funcional y diferenciado preeminente en la modernidad de la sociedad moderna.Si la captura del aparato estatal ha sido una de las características que definen la articulación del orden en la región, nos peguntamos cómo se estabilizaron esas estructuras, cómo incluso éstas definen las expectativas que orientan los presupuestos de la diferenciación funcional, operando factualmente con lógicas de un orden social estratificado y potenciando las prácticas clientelares.