bluuebunny/crossref_metadata_2025 huggingface dataset:
Key-Point-Descriptor-Based Image Quality Evaluation in Photogrammetry Workflows
Authors: Matuzevičius Dalius , Urbanavičius Vytautas , Miniotas Darius , Mikučionis Šarūnas , Laptik Raimond , Ušinskas Andrius
Published: May 2024

Photogrammetry depends critically on the quality of the images used to reconstruct accurate and detailed 3D models. Selection of high-quality images not only improves the accuracy and resolution of the resulting 3D models, but also contributes to the efficiency of the photogrammetric process by reducing data redundancy and computational demands. This study presents a novel approach to image quality evaluation tailored for photogrammetric applications that uses the key point descriptors typically encountered in image matching. Using a LightGBM ranker model, this research evaluates the effectiveness of key point descriptors such as SIFT, SURF, BRISK, ORB, KAZE, FREAK, and SuperPoint in predicting image quality. These descriptors are evaluated for their ability to indicate image quality based on the image patterns they capture. Experiments conducted on various publicly available image datasets show that descriptor-based methods outperform traditional no-reference image quality metrics such as BRISQUE, NIQE, PIQE, and BIQAA and a simple sharpness-based image quality evaluation method. The experimental results highlight the potential of using key-point-descriptor-based image quality evaluation methods to improve the photogrammetric workflow by selecting high-quality images for 3D modeling.
Enhanced Hyperspectral Sharpening through Improved Relative Spectral Response Characteristic (R-SRC) Estimation for Long-Range Surveillance Applications
Authors: Yuen Peter , Piper Jonathan , Yuen Catherine , Cakir Mehmet
Published: May 2024

The fusion of low-spatial-resolution hyperspectral images (LRHSI) with high-spatial-resolution multispectral images (HRMSI) for super-resolution (SR), using coupled non-negative matrix factorization (CNMF), has been widely studied in the past few decades. However, the matching of spectral characteristics between the LRHSI and HRMSI, which is required before they are jointly factorized, has rarely been studied. One objective of this work is to study how the relative spectral response characteristics (R-SRC) of the LRHSI and HRMSI can be better estimated, particularly when the SRC of the latter is unknown. To this end, three variants of enhanced R-SRC algorithms were proposed, and their effectiveness was assessed by applying them for sharpening data using CNMF. The quality of the output was assessed using the L1-norm-error (L1NE) and receiver operating characteristics (ROC) of target detections performed using the adaptive coherent estimator (ACE) algorithm. Experimental results obtained from two subsets of a real scene revealed a two- to three-fold reduction in the reconstruction error when the scenes were sharpened by the proposed R-SRC algorithms, in comparison with Yokoya’s original algorithm. Experiments also revealed that a much higher proportion (by one order of magnitude) of small targets of 0.015 occupancy in the LRHSI scene could be detected by the proposed R-SRC methods compared with the baseline algorithm, for an equal false alarm rate. These results may suggest the possibility of SR to allow long-range surveillance using low-cost HSI hardware, particularly when the remaining issues of the occurrence of large reconstruction errors and comparatively higher false alarm rate for ‘rare’ species in the scene can be understood and resolved in future research.
Regressive and Spatio-Temporal Accessibility of Variability in Solar Energy on a Short Scale Measurement in the Southern and Mid Region of Mozambique
Authors: Mucomole Fernando Venâncio , Silva Carlos Augusto Santos , Magaia Lourenço Lázaro
Published: May 2024

Solar energy reaching a horizontal surface can possess fluctuations that impact electricity generation at a solar plant. Despite this, energy access remains inadequate, particularly in rural areas, with an estimated 82% deficiency. This drives us to assess the regressive and spatial-temporal accessibility of solar energy in the southern and mid regions of Mozambique. This evaluation aims to determine the actual availability of energy for electrification purposes. Data on global horizontal irradiation from approximately 8 stations across all provinces in the specified regions, collected between 2012 and 2014 at intervals of 1 and 10 min, were analyzed using regression and correlation methods along with a specialized algorithm for classifying days based on clear sky index terms. The statistical analysis identified days with significant potential for energy accessibility, exceeding 50% of the average. The findings suggest a correlation coefficient of approximately 0.30 for energy and non-linear regression with clear sky index coefficients around 0.80. The method employed demonstrated accuracy when compared to theoretical simulations of the clear sky index in the region, indicating its potential applicability in other regions of interest.
Deep and Reinforcement Learning in Virtual Synchronous Generator: A Comprehensive Review
Authors: Ding Xiaoke , Cao Junwei
Published: May 2024

The virtual synchronous generator (VSG) is an important concept and primary control method in modern power systems. The penetration of power-electronics-based distributed generators in the power grid provides uncertainty and reduces the inertia of the system, thus increasing the risk of instability when disturbance occurs. The VSG produces virtual inertia by introducing the dynamic characteristics of the synchronous generator, which provides inertia and becomes a grid-forming control method. The disadvantages of the VSG are that there are many parameters to be adjusted and its operation process is complicated. However, with the rapid development of artificial intelligence (AI) technology, the powerful adaptive learning capability of AI algorithms provides potential solutions to this issue. Two research hotspots are deep learning (DL) and reinforcement learning (RL). This paper presents a comprehensive review of these two techniques combined with VSG control in the energy internet (EI). Firstly, the basic principle and classification of the VSG are introduced. Next, the development of DL and RL algorithms is briefly reviewed. Then, recent research on VSG control based on DL and RL algorithms are summarized. Finally, some main challenges and study trends are discussed.
Toward Intraoperative Visual Intelligence: Real-Time Surgical Instrument Segmentation for Enhanced Surgical Monitoring
Authors: Daneshgar Rahbar Mostafa , Pappas George , Jaber Nabih
Published: May 2024

Background: Open surgery relies heavily on the surgeon’s visual acuity and spatial awareness to track instruments within a dynamic and often cluttered surgical field. Methods: This system utilizes a head-mounted depth camera to monitor surgical scenes, providing both image data and depth information. The video captured from this camera is scaled down, compressed using MPEG, and transmitted to a high-performance workstation via the RTSP (Real-Time Streaming Protocol), a reliable protocol designed for real-time media transmission. To segment surgical instruments, we utilize the enhanced U-Net with GridMask (EUGNet) for its proven effectiveness in surgical tool segmentation. Results: For rigorous validation, the system’s performance reliability and accuracy are evaluated using prerecorded RGB-D surgical videos. This work demonstrates the potential of this system to improve situational awareness, surgical efficiency, and generate data-driven insights within the operating room. In a simulated surgical environment, the system achieves a high accuracy of 85.5% in identifying and segmenting surgical instruments. Furthermore, the wireless video transmission proves reliable with a latency of 200 ms, suitable for real-time processing. Conclusions: These findings represent a promising step towards the development of assistive technologies with the potential to significantly enhance surgical practice.
Analyzing the Problems of a District-Based Administration Using Monte Carlo Simulation: The Case of Sex Offender Notifications in Korea
Authors: Kim Hyemin , Lee Suyun , Jun Chulmin
Published: May 2024

The problems of administrations based simply on administrative units that do not consider the operational purposes of the system have been consistently discussed. For example, in the Republic of Korea, sex offenders’ information is distributed via physical mail only in a few regions, a practice that is too rigidly based on the boundaries of the administrative ‘Dong’ of the offender’s residence. This implies that citizens in an adjacent building will not be notified if their Dong is different. Therefore, this study analyzed the problems of an administrative system that does not consider its realistic scope by using the case study of sex offender notifications. By expanding the distance from children and youth grids, we ascertained the extent of the problems with sex offender notifications. Additionally, to determine whether these problems have occurred by chance at a specific point in time or if there has been a fundamental limitation in the system, the Monte Carlo simulation was applied to compare the actual and random data of residences.
Spatial-Temporal Evolution Characteristics Analysis of Color Steel Buildings in Lanzhou City
Authors: Wang Wenda , Li Xiao , Wang Ting , Wang Shaohua , Wang Runqiao , Xu Dachuan , Zhou Junyuan
Published: May 2024

With the continuous acceleration of China’s urbanization process, color steel plate, as a new type of building material, has been widely used in all kinds of temporary buildings and has become the spatial carrier of the specific development stage of urbanization. This study focuses on Lanzhou City as a case study to deeply analyze the spatiotemporal distribution and evolution of color steel plate buildings. Utilizing data extracted from Google imagery and GF-2 satellite images of the built-up areas in Lanzhou, spatial statistical and analytical methods such as centroid analysis, compactness index, and patch density are applied. Systematic analysis is conducted across different time periods and spatial scales to examine the evolution of indicators, including quantity, centroid distribution, spatial clustering, and distribution direction. The results show that from 2013 to 2021, the prevalence of color steel buildings in Lanzhou city initially increased and then decreased, and the number peaked in 2017, but there is a significant difference between distinct areas in the urban area. By quantitatively analyzing the spatial and temporal evolution characteristics of color steel plate buildings, this study reveals the important role it plays in promoting the urbanization process and provides a scientific basis for relevant planning decisions.
Application of Synephrine to Grape Increases Anthocyanin via Production of Hydrogen Peroxide, Not Phytohormones
Authors: Suzuki Masaya , Kimura Aoi , Suzuki Shunji , Enoki Shinichi
Published: May 2024

Global warming has caused such problems as the poor coloration of grape skin and the decreased production of high-quality berries. We investigated the effect of synephrine (Syn) on anthocyanin accumulation. Anthocyanin accumulation in cultured grape cells treated with Syn at concentrations of 1 mM or higher showed no significant difference, indicating that the accumulation was concentration-independent. On the other hand, anthocyanin accumulation was dependent on the compound used for treatment. The sugar/acid ratio of the juice from berries treated with Syn did not differ from the control. The expression of anthocyanin-biosynthesis-related genes, but not phytohormones, was increased by the treatment with Syn at 24 h or later. The Syn treatment of cultured cells increased SOD3 expression and hydrogen peroxide (H2O2) production from 3 to 24 h after treatment. Subsequently, the expression of CAT and APX6 encoding H2O2-scavenging enzymes was also increased. Treatment of cultured cells with Syn and H2O2 increased the expression of the H2O2-responsive gene Chit4 and the anthocyanin-biosynthesis-related genes mybA1 and UFGT 4 days after the treatment and increased anthocyanin accumulation 7 days after the treatment. On the other hand, the treatment of berries with Syn and H2O2 increased anthocyanin accumulation after 9 days. These results suggest that Syn increases anthocyanin accumulation through H2O2 production without changing phytohormone biosynthesis. Syn is expected to improve grape skin coloration and contribute to high-quality berry production.
Acute Kidney Injury in Sepsis
Authors: Pais Telma , Jorge Sofia , Lopes José António
Published: May 2024

Sepsis-associated kidney injury is common in critically ill patients and significantly increases morbidity and mortality rates. Several complex pathophysiological factors contribute to its presentation and perpetuation, including macrocirculatory and microcirculatory changes, mitochondrial dysfunction, and metabolic reprogramming. Recovery from acute kidney injury (AKI) relies on the evolution towards adaptive mechanisms such as endothelial repair and tubular cell regeneration, while maladaptive repair increases the risk of progression to chronic kidney disease. Fundamental management strategies include early sepsis recognition and prompt treatment, through the administration of adequate antimicrobial agents, fluid resuscitation, and vasoactive agents as needed. In septic patients, organ-specific support is often required, particularly renal replacement therapy (RRT) in the setting of severe AKI, although ongoing debates persist regarding the ideal timing of initiation and dosing of RRT. A comprehensive approach integrating early recognition, targeted interventions, and close monitoring is essential to mitigate the burden of SA-AKI and improve patient outcomes in critical care settings.
Catheter-Based Fetal Cardiac Interventions
Authors: Yilmaz Furtun Betul , Morris Shaine Alaine
Published: May 2024

Fetal cardiac intervention (FCI) is an emerging and rapidly advancing group of interventions designed to improve outcomes for fetuses with cardiovascular disease. Currently, FCI is comprised of pharmacologic therapies (e.g., trans-placental antiarrhythmics for fetal arrhythmia), open surgical procedures (e.g., surgical resection of pericardial teratoma), and catheter-based procedures (e.g., fetal aortic valvuloplasty for aortic stenosis). This review focuses on the rationale, criteria for inclusion, technical details, and current outcomes of the three most frequently performed catheter-based FCI procedures: (1) aortic valvuloplasty for critical aortic stenosis (AS) associated with evolving hypoplastic left heart syndrome (HLHS), (2) atrial septal intervention for HLHS with severely restrictive or intact atrial septum (R/IAS), and (3) pulmonary valvuloplasty for pulmonary atresia with intact ventricular septum (PA/IVS).
Diabetes Is Associated with Worse Postoperative Mortality and Morbidity in Bariatric Surgery, Regardless of the Procedure
Authors: Khalil Omar , Dargham Soha , Jayyousi Amin , Al Suwaidi Jassim , Abi Khalil Charbel
Published: May 2024

Background/Objectives: Bariatric surgery is a central cornerstone in obesity treatment. We aimed to assess the impact of diabetes on the postoperative outcomes of bariatric surgery and compare three techniques: sleeve gastrectomy, Roux-en-Y, and gastric banding. Methods: We extracted data from the National Inpatient Sample (2015–2019) using ICD codes. The primary outcome was postoperative mortality. Secondary outcomes were major bleeding, atrial fibrillation, and acute renal failure. Results: Among patients who underwent sleeve gastrectomy, diabetes was associated with a higher adjusted risk of mortality (aOR 2.07 [1.36–3.16]), atrial fibrillation, and acute renal failure, but a similar risk of bleeding. Among patients who underwent Roux-en-Y, diabetes did not increase mortality and bleeding risk. Still, it was associated with a higher risk of atrial fibrillation and acute renal failure. Among patients who underwent gastric banding, diabetes was only associated with a higher risk of bleeding. When comparing the three techniques in diabetes patients, Roux-en-Y was significantly associated with higher mortality and acute renal failure risk when compared to the other procedures. Bleeding was more common in Roux-en-Y than in Sleeve. Conclusions: In total, diabetes is associated with worse postoperative outcomes in bariatric surgery, regardless of the technique. Among diabetes patients, Roux-en-Y was associated with the highest mortality and morbidity.
The Role of Galectin-3 Levels for Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source
Authors: Çalapkorur Bekir , Demirci Erkan , Baran Oğuzhan , Ulusoy Ersin Kasım , Koçer Derya , Demirelli Selami , Gök Mustafa , Şimşek Ziya
Published: May 2024

Background/Objectives: Paroxysmal atrial fibrillation (PAF) is an important cause that is thought main potential factor in Embolic stroke of undetermined source (ESUS). Extended Holter ECG is an expensive and time-consuming examination. It needs another tools for predicting PAF in ESUS patients. In this study, serum galectin-3 levels, ECG parameters (PR interval, P wave time and P wave peak time) LA volume index, LA global peak strain and atrial electromechanical conduction time values were investigated for predicting PAF. Methods: 150 patients with ESUS and 30 volunteers for the control group were recruited to study. 48–72 h Holter ECG monitoring was used for detecting PAF. Patients were divided into two groups (ESUS + PAF and ESUS-PAF) according to the development of PAF in Holter ECG monitoring. Results: 30 patients with ESUS whose Holter ECG monitoring showed PAF, were recruited to the ESUS + PAF group. Other 120 patients with ESUS were recruited to the ESUS-PAF group. PA lateral, PA septum, and PA tricuspid were higher in the ESUS + PAF group (p < 0.001 for all). Serum galectin-3 levels were significantly higher in ESUS + PAF than in ESUS-PAF and control groups (479.0 pg/mL ± 435.8 pg/mL, 297.8 pg/mL ± 280.3 pg/mL, and 125.4 ± 87.0 pg/mL, p < 0.001, respectively). Serum galectin-3 levels were significantly correlated with LAVI, PA lateral, and global peak LA strain (r = 0.246, p = 0.001, p = 0.158, p = 0.035, r = −0.176, p = 0.018, respectively). Conclusion: Serum galectin-3 levels is found higher in ESUS patients which developed PAF and Serum galectin-3 levels are associated LA adverse remodeling in patients with ESUS.
Evaluating Treatment Outcomes for Pelvic Insufficiency Fractures: A Systematic Review
Authors: Sassara Giulia Maria , Smakaj Amarildo , De Mauro Domenico , Righini Roberta , Arnone Adele , Rovere Giuseppe , El Ezzo Omar , Farsetti Pasquale , Tarantino Umberto , Liuzza Francesco
Published: May 2024

Background: Pelvic insufficiency fractures (PIF) are typical in geriatric populations with reduced bone quality, most commonly in elderly postmenopausal women. These fractures are usually caused by low-energy forces over the bones during ordinary life and cause disabling pain. Treatment options range from conservative to operative. The aim of this study is to assess the outcomes of treatments for pelvic insufficiency fractures, determining optimal approaches between surgical intervention and conservative management. Methods: This literature review systematically examines articles focusing on patients with PIF, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and using PubMed, Medline, and the Cochrane Library database. We took into account only full-text articles in indexed journals with available English abstracts, considering data about patient demographics, surgery, and outcomes. Results: After screening 128 articles, this study reviewed 20 manuscripts involving 1499 patients, mostly elderly females and focusing on sacrum fractures. Common treatments included conservative methods and sacroplasty, with a few complications reported. Osteoporosis was the prevalent comorbidity, and the survival rate post-treatment was high at 92.3%. Mobility outcomes varied, with some patients experiencing significant autonomy loss. The average follow-up period was over 17 months. Conclusions: This study found a cautious approach to surgery (timing of three weeks), which is reserved only for specific patterns, and it leads to increased autonomy and a lower risk of mortality. Due to the lack of pre- and postoperative scores as well as conflicting results, it is imperative to undertake further studies and research to be able to compare the alternative treatments efficiently.
Prevalence and Burden of Musculoskeletal Pain among Cardiac Sonographers in Eastern Province of Saudi Arabia: A Cross-Sectional Study
Authors: Al Saikhan Lamia , Alshami Ali M.
Published: May 2024

Background: Cardiac sonographers are at a high risk for work-related musculoskeletal pain (WMSP), a major occupational health problem. With limited research on WMSP prevalence among this population in Saudi Arabia, this study aimed to investigate the prevalence and impact of WMSP in cardiac sonographers in the Eastern Province of Saudi Arabia compared to a control group of healthcare professionals. Methods: An electronic survey was administered to cardiac sonographers (study group) and other healthcare professionals (control group) exposed to different occupational hazards, including allied healthcare professionals, physicians, and nurses. Modified versions of the Nordic, QuickDASH, and QuickDASH work questionnaires were used. The χ2 test was performed for comparisons. Results: A total of 168 participants completed the survey (mean age: 31.6 ± 7.7 years). Among them, 127 (76.1%) were females, comprising 61 (36.3%) sonographers and 107 (63.7%) controls. Overall, WMSP was more common (82% versus 65%, p = 0.020) and severe (p = 0.041) in cardiac sonographers than in controls. The most affected body regions in cardiac sonographers were the shoulders (72.0% versus 29.0%), followed by the hands (56.0% versus 24.6%), compared to those of the control participants. Pain experienced by cardiac sonographers significantly interfered with social and work-related activities (p < 0.05 for all). A higher number of cardiac sonographers planned to change their profession than control participants (41% versus 15.2%; p < 0.0001) owing to pain. Conclusions: WMSP was more common and severe in cardiac sonographers than in control participants of other healthcare professions in the Eastern province of Saudi Arabia and interfered significantly with their social and work-related activities and future employment plans. Therefore, preventive interventional studies are required in the future.
Positive Orientation and Feelings of Loneliness among Polish Students during the COVID-19 Pandemic
Authors: Kupcewicz Ewa , Rachubińska Kamila , Cybulska Anna Maria , Jastrzębski Paweł , Bentkowska Aleksandra , Grochans Elżbieta
Published: May 2024

Background/Objectives: The COVID-19 pandemic was a time of limited direct contact with other people. The aim of this study was to determine the role of positive orientation and sociodemographic variables in the feelings of global, social and emotional loneliness and to seek predictors for loneliness among students during the COVID-19 pandemic. Methods: The study was conducted on a group of 798 students at the University of Warmia and Mazury in Olsztyn (Poland) between January and March 2022. The empirical data were gathered with the following research tools: the Positive Orientation Scale and the De Jong Gierveld Loneliness Scale—DJGLS. Results: The study found a correlation (r = −0.370; p < 0.001) between positive orientation and emotional loneliness. The level of loneliness was significantly higher in students who greatly reduced their social contact, compared to those who reduced them moderately (p < 0.001). The intensity of social loneliness among women was lower (p < 0.001) than among men. Those who lived with their families or with a close companion felt less intense emotional loneliness (p < 0.001) than those who lived alone. Conclusions: A positive orientation, which manifests itself in a favourable opinion about oneself and in attaching weight to positive aspects of life, was found to be the main determinant of the feelings of global and emotional loneliness. However, it did not prove to be a predictor of social loneliness in the group of students under study.
Beyond Mortality: Severely Frail Femur Fracture Patients Can Regain Independence after Surgery
Authors: Ponds Noa H. M. , Raats Jochem H. , Brameier Devon T. , Schuijt Henk Jan , Cooper Lisa , Sagona Abigail , Javedan Houman , Weaver Michael J.
Published: May 2024

Objectives: Little is known about the post-operative functional outcomes of severely frail femur fracture patients, with previous studies focusing on complications and mortality. This study investigated patient- or proxy-reported outcomes after femur fracture surgery in older adult patients with severe frailty. Methods: This was a retrospective cross-sectional study of older adult (>70 years) patients with severe frailty (defined by a Comprehensive Geriatric Assessment-based Frailty Index (FI-CGA) ≥ 0.40), who underwent femur fracture surgery at a Level 1 Trauma Center. Patients or their proxy (i.e., close relative) reported mobility, psychosocial, and functional outcomes at least 1-year after surgery. Results: Thirty-seven predominantly female (76%) patients with a median age of 85 years (IQR 79–92), and a median FI-CGA of 0.48 (IQR 0.43–0.54) were included. Eleven patients (30%) regained pre-fracture levels of ambulation, with twenty-six patients (70%) able to walk with or without assistance. The majority of patients (76%) were able to have meaningful conversations. Of the patients, 54% of them experienced no to minimal pain, while 8% still experienced a lot of pain. Functional independence varied, as follows: five patients (14%) could bathe themselves; nine patients (25%) could dress themselves; fourteen patients (39%) could toilet independently; and seventeen patients (47%) transferred out of a (wheel)chair independently. Conclusions: Despite the high risk of mortality and perioperative complications, many of the most severely frail patients with surgically treated femur fractures regain the ability to ambulate and live with a moderate degree of independence. This information can help healthcare providers to better inform these patients and their families of the role of surgical treatment during goals of care discussions.
Numerical Study of the Force Characteristics and Flow Field Patterns of a Cylinder in the Internal Solitary Wave
Authors: Zhang Miao , Hu Haibao , Ouahsine Abdellatif , Du Peng , Huang Xiao , Xie Luo
Published: May 2024

The density of the ocean is unevenly distributed along the depth direction, showing a stratified structure. When there is an external disturbance, large-scale internal solitary waves are easily generated. The internal solitary waves are bounded by the intermediate pycnocline, and the currents in the upper and lower layers will flow in opposite directions. This generates strong shear forces that threaten the safety of marine structures. In this paper, the flow field distribution characteristics of a cylinder under the action of internal solitary waves at different scales are analyzed as a research object. The whole cylinder is discretized into 40 regions, and the horizontal force applied to each section of the cylinder is extracted. The force characteristics of the cylinder are analyzed. It is concluded that the pressure is the main factor determining the magnitude of the total combined force. In addition, the paper extracts the main flow structures from the modal decomposition point of view and explains the reasons affecting the force behavior of the cylinder.
European Structural and Investment Funds (ESIFs) and Regional Development across the European Union (EU)
Authors: Spilioti Nikolitsa , Anastasiou Athanasios
Published: May 2024

This scoping review synthesizes the evidence from eleven key studies to assess the impact of European Structural and Investment Funds (ESIFs) on regional development across the European Union (EU), focusing on fund efficiency, regional disparities and convergence, governance quality, economic freedom, and fund management. A systematic search was conducted across multiple databases to identify the relevant literature published up to 2023. Eleven studies were selected based on the date published and their focus on ESIFs’ role in regional development, employing a range of methodological approaches including Data Envelopment Analysis (DEA), spatial econometrics, and multivariate analyses. The thematic analysis identified four main categories: Methodological Approaches in Evaluating Fund Efficiency, Regional Disparities and Convergence, The Interconnection between Governance Quality, Economic Freedom, and the Efficiency of Structural Fund Management, and The Absorption Capacity and Fund Management. The review highlights the importance of sophisticated analytical tools in evaluating fund efficiency, with DEA and spatial econometrics providing critical insights into fund management efficiency. Studies underscored the nuanced efficacy of ESIFs in reducing regional disparities, albeit pointing to the need for more targeted fund allocation. Governance quality and economic freedom emerged as pivotal factors enhancing fund management efficiency, suggesting the potential of governance reforms in optimizing ESIF allocation and utilization. Challenges related to fund absorption and management were illuminated, advocating for enhanced institutional management capabilities and the development of innovative performance indicators. The findings of this scoping review contribute to a deeper understanding of the complexities surrounding ESIFs’ impact on regional development within the EU. They underscore the critical importance of governance quality, economic freedom, methodological rigor, and strategic fund allocation in enhancing the effectiveness of ESIFs. The review calls for tailored policy interventions and the integration of national and European funding strategies to maximize the impact of these programs on regional development and SME support. Future research should continue to refine these methodological approaches and explore the causal effects of funding, to enhance our understanding of ESIFs’ efficiency in promoting regional development and convergence within the European Union.
Beyond the Bile: Exploring the Microbiome and Metabolites in Cholangiocarcinoma
Authors: Lee Jungnam , Kim Hanul , Park Jin-Seok
Published: May 2024

Introduction: Cholangiocarcinoma (CCC) still has a high mortality rate despite improvements in diagnostic and therapeutic techniques. The role of the human microbiome in CCC is poorly understood, and a recent metagenomic analysis demonstrated a significant correlation between microbiome-associated carcinogenesis and CCC. This study aimed to investigate changes in microbiome composition associated with CCC and its metabolic signature by integrating taxonomic and functional information with metabolomics data and in vitro experimental results. Methods: From February 2019 to January 2021, this study included patients who underwent endoscopic retrograde cholangiopancreatography (ERCP), both with and without a diagnosis of CCC. Bile samples were collected via endoscopic nasobiliary drainages (ENBD) and subjected to DNA extraction, PCR amplification of the bacterial 16S rRNA gene V3-V4 region, and data analysis using QIIME2. In vitro Carboxyfluorescein succinimidyl ester (CFSE) proliferation and Annexin V/PI apoptosis assays were performed to investigate the effects of metabolites on CCC cells. Results: A total of 24 patients were included in the study. Bile fluid analysis revealed a significantly higher abundance of Escherichia coli in the CCC group. Alpha diversity analyses exhibited significant differences between the CCC and non-CCC groups, and Nuclear Magnetic Resonance (NMR) spectroscopy metabolic profiling identified 15 metabolites with significant concentration differences; isoleucine showed the most notable difference. In vitro experiments demonstrated that isoleucine suppressed CCC cell proliferation but did not induce apoptosis. Conclusions: This research underlines the significance of biliary dysbiosis and specific bile metabolites, such as isoleucine, in influencing the development and progression of CCC.
A Set Covering Approach to Design Maximally Permissive Supervisors for Flexible Manufacturing Systems
Authors: Li Yongyao , Chen Yufeng , Zhou Rui
Published: May 2024

The supervisory control of Petri nets aims to enforce the undesired behavior as unreachable by designing a set of control places. This work presents a set cover approach to design maximally permissive supervisors. For each first-met bad marking, an integer linear programming problem is developed to obtain a control place to prohibit it. An objective function is formulated to make the maximal number of first-met bad markings forbidden. Then, we develop a set covering approach to minimize the number of selected control places. The proposed approach can guarantee the maximal permissiveness of the obtained supervisor and provide a trade-off between structural complexity and computational cost. Several examples are considered to validate the proposed method.
Posterior-Only T11 Vertebral Column Resection for Pediatric Congenital Kyphosis Surgical Correction
Authors: Grabala Pawel , Fani Negin , Gregorczyk Jerzy , Grabala Michal
Published: May 2024

Background: Congenital kyphosis is a spinal deformity that arises from the inadequate anterior development or segmentation of the vertebrae in the sagittal plane during the initial embryonic stage. Consequently, this condition triggers atypical spinal growth, leading to the manifestation of deformity. Concurrently, other congenital abnormalities like renal or cardiac defects within the gastrointestinal tract may co-occur with spinal deformities due to their shared formation timeline. In light of the specific characteristics of the deformity, the age range of the patient, deformity sizes, and neurological conditions, surgical intervention emerges as the optimal course of action for such cases. The selection of the appropriate surgical approach is contingent upon the specific characteristics of the anomaly. Case Presentation: This investigation illustrates the utilization of a surgical posterior-only strategy for correcting pediatric congenital kyphoscoliosis through the implementation of a vertebral column resection method along with spine reconstruction employing a mesh cage. The individual in question, a 16-year-old female, exhibited symptoms such as a progressive rib hump, shoulder asymmetry, and back discomfort. Non-invasive interventions like bracing proved ineffective, leading to the progression of the spinal curvature. After the surgical procedure, diagnostic imaging displayed a marked enhancement across all three spatial dimensions. After a postoperative physical assessment, it was noted that the patient experienced significant enhancements in shoulder alignment and rib hump prominence, with no discernible neurological or other adverse effects. Conclusions: Surgical intervention is considered the optimal approach for addressing such congenital anomalies. Typically, timely surgical intervention leads to favorable results and has the potential to halt the advancement of deformity and curvature enlargement.
Purpureocillium lilacinum SBF054: Endophytic in Phaseolus vulgaris, Glycine max, and Helianthus annuus; Antagonistic to Rhizoctonia solani; and Virulent to Euschistus heros
Authors: Moreira Flávia Melo , Machado Túlio Iglésias , Torres Caio Augusto Rosado , Souza Hebert Ribeiro de , Celestino Matheus Felipe , Silva Marco Antônio , Gomes Giovana Cidade , Cunha Breno Beda dos Reis , Santos Pedro de Luca Buffon dos , Carvalho Filho Magno Rodrigues de , Castro Marcelo Tavares de , Monnerat Rose Gomes
Published: May 2024

Microorganisms with multiple ecological functions can be a useful biotechnological resource in integrated pest- and disease-management programs. This work aimed to investigate the potential endophytic and virulent effects of a strain of Purpureocillium lilacinum on organic cultivation in Brazil. Specifically, the strain’s ability to establish itself as an endophyte in common bean, soybean, and sunflower plants when inoculated via seed was evaluated. Furthermore, its antifungal activity against phytopathogens and its pathogenicity and virulence against insects of the order Lepidoptera, Coleoptera, and Hemiptera were evaluated. Furthermore, the strain was evaluated for its biochemical and physiological characteristics. For virulence bioassays, the experiments were conducted under a factorial scheme (2 × 3), with the following factors: (a) fungal inoculation and control without inoculum and (b) types of inocula (blastospores, aerial conidia, and metabolites). The treatments were sprayed on insect species at different stages of development. In summary, it was found that the SBF054 strain endophytically colonized the common bean, with partial recovery from the root tissues of soybean and sunflower plants, 30 days after inoculation; suppressed 86% of Rhizoctonia solani mycelial growth in an in vitro assay; and controlled eggs, nymphs, and Euschistus heros adults. These multifunctional abilities are mainly attributed to the strain’s mechanisms of producing metabolites, such as organic acids, soluble nutrients, and hydrolytic enzymes.
Temporal and Spatial Dynamics of Vibrio harveyi: An Environmental Parameter Correlation Investigation in a 4-Metre-Deep Dicentrarchus labrax Aquaculture Tank
Authors: Da Fonseca Ferreira Alix , Roquigny Roxane , Grard Thierry , Le Bris Cédric
Published: May 2024

Nowadays, European seabass (Dicentrarchus labrax) aquaculture is undergoing a significant expansion. Nevertheless, the aquaculture industry is plagued by vibriosis. The spatial and temporal dynamics of Vibrio harveyi were studied on a European seabass farm in northern France during seven months of 2022. Concrete specimens were suspended and water was pumped from different depths (0.3 m, 2.15 m and 4 m deep), providing insights into the biofilm and planktonic V. harveyi dynamics. The abundances of V. harveyi, in the biofilm and free-living forms, were positively correlated. The water parameters revealed seasonal fluctuations in temperature, pH, and salinity, with no significant differences observed across the water column. Quantification of V. harveyi revealed no significant differences between depths, but seasonality, with peak abundances observed in August, correlated with temperature increases. Principal component analysis identified temperature as a primary driver, but also additional parameters, such as salinity and pH. Vibriosis occurred during the sampling period, providing valuable insights into the conditions before, during, and after the outbreaks. This study underscores the importance of understanding V. harveyi behaviour in aquaculture, particularly in the context of global warming, for effective disease management and sustainable practices.
Synthesis and Electrocatalytic Performance Study of Sulfur Quantum Dots Modified MoS2
Authors: Wei Guiyu , Tang Tao , Xu Ruizheng , Xie Zhemin , Diao Sijie , Wen Jianfeng , Jiang Li , Hu Guanghui , Li Ming
Published: May 2024

The electrolysis of water for hydrogen production is currently receiving significant attention due to its advantageous features such as non-toxicity, safety, and environmental friendliness. This is especially crucial considering the urgent need for clean energy. However, the current method of electrolyzing water to produce hydrogen largely relies on expensive metal catalysts, significantly increasing the costs associated with its development. Molybdenum disulfide (MoS2) is considered the most promising alternative to platinum for electrocatalyzing the hydrogen evolution reaction (HER) due to its outstanding catalytic efficiency and robust stability. However, the practical application of this material is hindered by its low conductivity and limited exposure of active sites. MoS2/SQDs composite materials were synthesized using a hydrothermal technique to deposit SQDs onto MoS2. These composite materials were subsequently employed as catalysts for the HER. Research findings indicate that incorporating SQDs can enhance electron transfer rates and increase the active surface area of MoS2, which is crucial for achieving outstanding catalytic performance in the HER. The MoS2/SQDs electrocatalyst exhibits outstanding performance in the HER when tested in a 0.5 M H2SO4 solution. It achieves a remarkably low overpotential of 204 mV and a Tafel slope of 65.82 mV dec−1 at a current density of 10 mA cm−2. Moreover, during continuous operation for 24 h, the initial current density experiences only a 17% reduction, indicating high stability. This study aims to develop an efficient and cost-effective electrocatalyst for water electrolysis. Additionally, it proposes a novel design strategy that uses SQDs as co-catalysts to enhance charge transfer in nanocomposites.
Comparative Transcriptome and sRNAome Analysis Suggest Coordinated Citrus Immune Responses against Huanglongbing Disease
Authors: Bilal Muhammad Saqib , Paul Gomes , Yu Ze , Xu Le , Cheng Tang , Cheng Baoping , Aslam Muhammad Naveed , Baig Ayesha , Zhao Hongwei
Published: May 2024

Citrus Huanglongbing (HLB), caused by the phloem-inhibiting bacterium Candidatus Liberibacter asiaticus (CLas), is the most devastating citrus disease, intimidating citrus production worldwide. Although commercially cultivated citrus cultivars are vulnerable to CLas infection, HLB-tolerant attributes have, however, been observed in certain citrus varieties, suggesting a possible pathway for identifying innate defense regulators that mitigate HLB. By adopting transcriptome and small RNAome analysis, the current study compares the responses of HLB-tolerant lemon (Citrus limon L.) with HLB-susceptible Shatangju mandarin (Citrus reticulata Blanco cv. Shatangju) against CLas infection. Transcriptome analysis revealed significant differences in gene expression between lemon and Shatangju. A total of 1751 and 3076 significantly differentially expressed genes were identified in Shatangju and lemon, respectively. Specifically, CLas infected lemon tissues demonstrated higher expressions of genes involved in antioxidant enzyme activity, protein phosphorylation, carbohydrate, cell wall, and lipid metabolism than Shatangju. Wet-lab experiments further validated these findings, demonstrating increased antioxidant enzyme activity in lemon: APX (35%), SOD (30%), and CAT (64%) than Shatangju. Conversely, Shatangju plants exhibited higher levels of oxidative stress markers like H2O2 (44.5%) and MDA content (65.2%), alongside pronounced ion leakage (11.85%), than lemon. Moreover, microscopic investigations revealed that CLas infected Shatangju phloem exhibits significantly more starch and callose accumulation than lemon. Furthermore, comparative sRNA profiles revealed the potential defensive regulators for HLB tolerance. In Shatangju, increased expression of csi-miR166 suppresses the expression of disease-resistant proteins, leading to inadequate defense against CLas. Conversely, reduced expression of csi-miR166 in lemon plants enables them to combat HLB by activating disease-resistance proteins. The above findings indicate that when infected with CLas, lemon exhibits stronger antioxidative activity and higher expression of disease-resistant genes, contributing to its enhanced tolerance to HLB. In contrast, Shatangju shows lower antioxidative activity, reduced expression of disease-resistant genes, significant ion leakage, and extensive callose deposition, possibly related to damage to plant cell structure and blockage of phloem sieve tubes, thereby promoting the development of HLB symptoms.
Impact of Cyclic Error on Absolute Distance Measurement Based on Optical Frequency Combs
Authors: Li Runmin , Tian Haochen , Shi Junkai , Ji Rongyi , Dong Dengfeng , Zhou Weihu
Published: May 2024

Absolute distance measurements based on optical frequency combs (OFCs) have greatly promoted advances in both science and technology, owing to the high precision, large non-ambiguity range (NAR), and a high update rate. However, cyclic error, which is extremely difficult to eliminate, reduces the linearity of measurement results. In this study, we quantitatively investigated the impact of cyclic error on absolute distance measurement using OFCs based on two types of interferometry: synthetic wavelength interferometry and single-wavelength interferometry. The numerical calculations indicate that selecting a suitable reference path length can minimize the impact of cyclic error when combining the two types of interferometry. Recommendations for selecting an appropriate synthetic wavelength to address the tradeoff between achieving a large NAR and minimizing the risk of failure when combining the two methods are provided. The results of this study are applicable not only in absolute distance measurements but also in other applications based on OFCs, such as surface profile, vibration analysis, etc.
An Optical Sensor for Measuring Displacement between Parallel Surfaces
Authors: Ahamed Suhana Jamil , McGeehan Michael , Ong Keat Ghee
Published: May 2024

An optoelectronic sensor was developed to measure the in-plane displacement between two parallel surfaces. This sensor used a photodetector, which was placed on one of the parallel surfaces, to measure the intensity of the red (R), green (G), blue (B), and white/clear (C) light spectra of a broad-spectrum light that was reflected off a color grid on the opposing surface. The in-plane displacement between these two surfaces caused a change in the reflected RGB and C light intensity, allowing the prediction of the displacement direction and magnitude by using a polynomial regression prediction algorithm to convert the RGB and C light intensity to in-plane displacement. Results from benchtop experiments showed that the sensor can achieve accurate displacement predictions with a coefficient of determination R2 > 0.97, a root mean squared error (RMSE) < 0.3 mm, and a mean absolute error (MAE) < 0.36 mm. By measuring the in-plane displacement between two surfaces, this sensor can be applied to measure the shear of a flexible layer, such as a shoe’s insole or the lining of a limb prosthesis. This sensor would allow slippage detection in wearable devices such as orthotics, prostheses, and footwear to quantify the overfitting or underfitting of these devices.
FF-HPINet: A Flipped Feature and Hierarchical Position Information Extraction Network for Lane Detection
Authors: Zhou Xiaofeng , Zhang Peng
Published: May 2024

Effective lane detection technology plays an important role in the current autonomous driving system. Although deep learning models, with their intricate network designs, have proven highly capable of detecting lanes, there persist key areas requiring attention. Firstly, the symmetry inherent in visuals captured by forward-facing automotive cameras is an underexploited resource. Secondly, the vast potential of position information remains untapped, which can undermine detection precision. In response to these challenges, we propose FF-HPINet, a novel approach for lane detection. We introduce the Flipped Feature Extraction module, which models pixel pairwise relationships between the flipped feature and the original feature. This module allows us to capture symmetrical features and obtain high-level semantic feature maps from different receptive fields. Additionally, we design the Hierarchical Position Information Extraction module to meticulously mine the position information of the lanes, vastly improving target identification accuracy. Furthermore, the Deformable Context Extraction module is proposed to distill vital foreground elements and contextual nuances from the surrounding environment, yielding focused and contextually apt feature representations. Our approach achieves excellent performance with the F1 score of 97.00% on the TuSimple dataset and 76.84% on the CULane dataset.