bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuromuscular control in males and females 1 year after an anterior cruciate ligament rupture or reconstruction during stair descent and artificial tibial translation
Authors: Blasimann Angela , Busch Aglaja , Henle Philipp , Bruhn Sven , Vissers Dirk , Baur Heiner
Published: September 2023

Neuromuscular alterations are reported in patients with anterior cruciate ligament reconstruction (ACL-R) and conservative treatment (copers with ACL deficiency, ACL-C). However, it is unclear whether sex influences neuromuscular control. The objective was to investigate differences in neuromuscular control regarding sex and treatment type one year after ACL rupture in comparison to a group with an intact ACL (ACL-I). Electromyography of vastus medialis (VM) and lateralis, biceps femoris (BF) and semitendinosus (ST) was recorded in ACL-R (N = 38), ACL-C (N = 26), and ACL-I (N = 38) during stair descent and reflex activity by anterior tibial translation while standing. The movements of stair descent were divided into pre-activity, weight-acceptance and push-off phases, reflex activity in pre-activation, short, medium (MLR), and long latency responses (LLR). Normalized root mean squares for each muscle of involved and matched control limb per phase were calculated and analyzed with two-way ANOVA (α = 0.05). During stair descent, neuromuscular differences of BF were significant during push-off only (p = 0.001). Males of ACL-R and ACL-C had higher BF activity compared to ACL-I (p = 0.009, 0.007 respectively). During reflex activity, VM and BF were significantly different between treatment groups for pre-activation (p = 0.013, 0.035 respectively). VM pre-activation of females was higher in ACL-R compared to ACL-C (p = 0.018), and lower in ACL-C compared to ACL-I (p = 0.034). Males of ACL-R showed higher VM and less BF pre-activation (p = 0.025, p = 0.003 respectively) compared to ACL-I. Males of ACL-C had less BF pre-activation compared to ACL-I (p = 0.019). During MLR, intra-group differences in ST were found for treatment (p = 0.011) and females of ACL-R compared to ACL-I (p = 0.015). During LLR, overall intra-group differences in VM were present for treatment (p = 0.034) and in females (ACL-R versus ACL-C (p = 0.015), ACL-I (p = 0.049), respectively). One year after an ACL rupture, neuromuscular alterations persist regardless of treatment and sex. Standard rehabilitation protocols may not be able to restore neuromuscular control. Future research should include long-term follow up and focus on exercises targeting neuromuscular function.
Arctic shipping trends during hazardous weather and sea-ice conditions and the Polar Code’s effectiveness
Authors: Müller Malte , Knol-Kauffman Maaike , Jeuring Jelmer , Palerme Cyril
Published: September 2023

The Arctic’s extreme environmental conditions and remoteness make it a complex and dynamic environment for maritime operators. We find that Arctic shipping has grown by 7% per year over the past decade, despite the hazardous weather and sea-ice conditions that pose risks to vessels operating in the region. As a result of a strong increase in winter sailing, the time ships operate in these extreme conditions has even tripled. To mitigate maritime risks, the Polar Code has been introduced. Among other things, it regulates Arctic shipping by specifying hazardous conditions with a sea-ice classification scheme and design temperature threshold. However, we argue that the Polar Code needs refinement through the integration of maritime warning systems and a broader description of hazardous conditions. This is supported by an analysis of shipping activity patterns in severe sea-spray icing conditions and a discussion of a recent sea-ice induced incident along the Northern Sea Route.
Activation of robust bonds by carbonyl complexes of Mn, Fe and Co
Authors: Radzhabov Maxim R. , Mankad Neal P.
Published: September 2023

Historic discoveries and recent advances in activation of strong C–H, C–F, and C–O bonds using carbonyl complexes of Mn, Fe, and Co are reviewed.
Photonic features of blue phase liquid crystals under curved confinement
Authors: Money Jeremy , Munguia-Fernández Juan G. , Norouzi Sepideh , Esmaeili Mohsen , Martínez-González José A. , Sadati Monirosadat
Published: September 2023

A discussion of the influence of spatial confinement and curved boundaries on the photonic properties of Blue Phase soft nanocrystals.
Six novel multicomponent systems of theobromine with carboxylic acids: crystallographic structures, solubility determination and DFT calculations
Authors: Yuan Xin-Yue , Cheng Yan , Liu Jun , Sun Qi-Lei , Xue Fu-Min
Published: September 2023

Cocrystals of theobromine with carboxylic acids prepared by ball milling and solution method: crystallographic structures and solubility determination.
A curcumin-nicotinoyl derivative and its transition metal complexes: synthesis, characterization, andin silicoandin vitrobiological behaviors
Authors: Hosseini Marziyeh-Sadat , Hadadzadeh Hassan , Mirahmadi-Zare Seyede Zohreh , Farrokhpour Hossein , Aboutalebi Fatemeh , Morshedi Dina
Published: September 2023

Curcumin-nicotinoyl (Cur-Nic) was synthesized by chemical modification of the curcumin structure, characterized, and used as a ligand for the synthesis of copper(ii) and zinc(ii) complexes.
A facile in situ interfacial construction strategy of hierarchically distributed mixed-metal layered hydroxide/cellulose membranes towards efficient wastewater purification
Authors: Zhang Shuo , Shu Liping , Fang Haohang , Zhu Weizhi , Sun Jianping , Yang Fang , Wu Yiqiang , Shi Shaohong , Cheng Fangchao
Published: September 2023

From material synthesis to functional evaluation, this study provides important insights into the in situ, convenient, and green synthesis of cellulose-based multifunctional catalytic materials towards efficient wastewater purification.
Efficient filter-in-centrifuge separation of low-concentration bacteria from blood
Authors: Zeng Kaiyang , Osaid Mohammad , van der Wijngaart Wouter
Published: September 2023

Septic blood centrifugation over an inclined filter efficiently separates bacteria from blood cells at clinically relevant concentrations.
Gradient heating induced better balance among water transportation, salt resistance and heat supply in a high performance multi-functional solar-thermal desalination device
Authors: Chen Chuanliang , Xiong Lianhu , Zhang Xuezhong , Tian Ke , Dai Zijian , Fu Qiang , Deng Hua
Published: September 2023

Solar-driven desalination (SDD) is a promising technology for addressing water scarcity.
Structural investigations of Au–Ni aerogels: morphology and element distribution
Authors: Kresse Johannes , Georgi Maximilian , Hübner René , Eychmüller Alexander
Published: September 2023

Novel Au–Ni aerogels have been successfully synthesized in common metal aerogel morphologies: alloys, heterostructures and hollow spheres. The morphological features and structural trends were related to the physicochemical and catalytic properties.
A pH-responsive supramolecular antibacterial agent based on host–guest chemistry
Authors: Xiong Ren-Yi , Ruan Yi-Ru , Zhou Na , Wang Xiao-Qiang , Li Lingling , Wang Wenjing
Published: September 2023

Supramolecular chemistry regulates the antibacterial activity of DQ using CB[7] and ADA–MA according to the pH value of the infection microenvironment.
The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe
Authors: Kuo Chi-Lin , Su Qin , van den Nieuwendijk Adrianus M. C. H. , Beenakker Thomas J. M. , Offen Wendy A. , Willems Lianne I. , Boot Rolf. G. , Sarris Alexi J. , Marques André R. A. , Codée Jeroen D. C. , van der Marel Gijsbert A. , Florea Bogdan I. , Davies Gideon J. , Overkleeft Herman S. , Aerts Johannes M. F. G.
Published: September 2023

Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism.
Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates
Authors: Zhou Ping-Xin , Liu Yang , Du Xueyan , Liu Ning , Li Kexin , Wu Yuji , Feng Wang , Liu Xu , Kong Yingying
Published: September 2023

A palladium-catalyzed highly regio- and stereoselective reaction of alkynyl aryl iodide with allenyl malonates was realized to afford a series of bicyclic compounds.
Magnetic-responsive solid acid catalysts for esterification
Authors: Xue Dan , Jiang Yun , Zheng Fangxia
Published: September 2023

Two kinds of magnetic-responsive solid acid catalysts were designed and prepared via an in situ polymerization of poly(ionic liquid)s (PILs) on the surface of Fe3O4@SiO2 NPs for the catalyzed esterification of palmitic acid and methanol.
Correction: Enhanced charge transport properties of an LFP/C/graphite composite as a cathode material for aqueous rechargeable lithium batteries
Authors: Duan Wenyuan , Mubasher  , Li Yanlin , Lashari Najeeb ur Rehman , Yang Yuhuan , Ma Cheng , Zhao Yuzhen , Li Xiaorui
Published: September 2023

Correction for ‘Enhanced charge transport properties of an LFP/C/graphite composite as a cathode material for aqueous rechargeable lithium batteries’ by Wenyuan Duan et al., RSC Adv., 2023, 13, 25327–25333, https://doi.org/10.1039/D3RA04143C.
Participation of the unstable lattice oxygen of cation-exchanged δ-MnO2 in the water oxidation reaction
Authors: Ham Kahyun , Kang Sinwoo , Kim Yeongin , Lee Youjin , Kim Young-Dok , Lee Jaeyoung
Published: September 2023

The isotopic shift of the Mn–O bonds in Co2+/MnO2 indicates that the lattice oxygen is replaced by the electrolyte, shifting the OER mechanism to a lattice oxygen participation mechanism.
Internal electric fields in asymmetric single-layer lattices for enhancing photocatalytic solar-to-hydrogen efficiency
Authors: Liu Yuliang , Wan Yongfeng , Li Bo , Yang Chuanlu , Lv Xingshuai , Shi Ying
Published: September 2023

MSi2N3Y monolayers are proposed as a promising candidate for overall water splitting with high solar-to-hydrogen efficiency.
Roof tile-inspired 3D arch evaporators based on Ti3C2Tx/MoSe2 photothermal nanocomposites for efficient solar desalination
Authors: Zhao Jun , Cui Hongzhi , Xu Ruiqi , Yang Jinlai , Li Leigang , Wei Na , Song Xiaojie
Published: September 2023

The solar absorbance, self-cleaning, and air insulating barrier schematic of 3D arch evaporator based on Ti3C2Tx/MoSe2/carbon cloth.
Investigation of sensitive SERS detection via a perovskite-coated Ag nanofilm
Authors: Pan Niu , Tian Jun , Shi Ziqian , Zhang Wen , Gao Yukun , You Tingting , Yin Penggang
Published: September 2023

A perovskite-coated silver nanofilm substrate realizes high sensitivity detection of probe molecules.
Piperazine: a promising building block for aggregation-induced emission materials
Authors: Peng Tuokai , Peng Hui-Qing
Published: September 2023

We report piperazine as a promising building block for the construction of aggregation-induced emission (AIE) materials by using its electron-donating ability and chair conformation.
Correction: Understanding the lithiation mechanism of Li2O-doped spinel high-entropy oxides as anode materials for Li-ion batteries
Authors: Ma Guozheng , Zheng Yu , Meng Fanbo , Hu Renzong
Published: September 2023

Correction for ‘Understanding the lithiation mechanism of Li2O-doped spinel high-entropy oxides as anode materials for Li-ion batteries’ by Renzong Hu et al., Energy Adv., 2023, https://doi.org/10.1039/D3YA00326D.
Nonverbal Executive Functioning in Relation to Vocabulary and Morphosyntax in Preschool Children With and Without Developmental Language Disorder
Authors: Everaert Emma , Boerma Tessel , Selten Iris , Gerrits Ellen , Houben Michiel , Vorstman Jacob , Wijnen Frank
Published: September 2023

Purpose:

Developmental language disorder (DLD) is characterized by persistent and unexplained difficulties in language development. Accumulating evidence shows that children with DLD also present with deficits in other cognitive domains, such as executive functioning (EF). There is an ongoing debate on whether exclusively verbal EF abilities are impaired in children with DLD or whether nonverbal EF is also impaired, and whether these EF impairments are related to their language difficulties. The aims of this study were to (a) compare nonverbal performance of preschoolers with DLD and typically developing (TD) peers, (b) examine how nonverbal EF and language abilities are related, and (c) investigate whether a diagnosis of DLD moderates the relationship between EF and language abilities.

Method:

A total of 143 children (
n
DLD
= 65,
n
TD
= 78) participated. All children were between 3 and 6.5 years old and were monolingual Dutch. We assessed nonverbal EF with a visual selective attention task, a visuospatial short-term and working memory task, and a task gauging broad EF abilities. Vocabulary and morphosyntax were each measured with two standardized language tests. We created latent variables for EF, vocabulary, and morphosyntax.

Results:

Analyses showed that children with DLD were outperformed by their TD peers on all nonverbal EF tasks. Nonverbal EF abilities were related to morphosyntactic abilities in both groups, whereas a relationship between vocabulary and EF skills was found in the TD group only. These relationships were not significantly moderated by a diagnosis of DLD.

Conclusions:

We found evidence for nonverbal EF impairments in preschool children with DLD. Moreover, nonverbal EF and morphosyntactic abilities were significantly related in these children. These findings may have implications for intervention and support the improvement of prognostic accuracy.

Supplemental Material:

https://doi.org/10.23641/asha.24121287
An efficient coprime integer sets based rendezvous algorithm for distributed cognitive radio networks
Authors: Wei Zongheng , Liu Qinglin , Lin Zhiyong , Wen Qingji , Wen Jianfeng , Liu Hai , Wu Wenjun
Published: September 2023

Multichannel blind rendezvous problem is a fundamental problem in cognitive radio networks (CRNs). It refers to how to ensure that any two secondary users can meet on a common available channel at the same time. In this paper, an efficient channel hopping algorithm, called CISR (Coprime Integer Sets based Rendezvous), is designed for asymmetric role model (i.e. users can be divided into two types of roles, say, sender/leader and receiver/follower) in distributed CRNs. CISR can guarantee the rendezvous of the leader and follower and lowers the upper bound of both the maximum time to rendezvous and expected time to rendezvous by carefully constructing two coprime integer sets. The simulation results show that CISR has the near‐optimal performance.
MFFN: Multi‐path feedback fusion network for lightweight image super resolution
Authors: Xue LiXia , Shen JunHui , Wang RongGui , Yang Juan
Published: September 2023

Recently, convolutional neural network (CNN) has shown great power in single image super resolution (SISR) reconstruction, and achieving significant improvements over traditional methods. Despite the great success of these CNN‐based methods, direct application of these methods to some edge devices is impractical due to the large computational overhead required. To address this problem, a novel, lightweight SISR network focusing on speed and accuracy, called the multi‐path feedback fusion network (MFFN), has been designed in this paper. Specifically, in order to extract features more effectively, the authors propose a novel fusion attention feedback block (FAFB) as the main building block of MFFN. The FAFB consists of a backbone branch and several hierarchical branches. The backbone branch is composed of stacked enhanced pixel attentional blocks (EPAB), which are responsible for incremental deep feature learning on the feature map. And the hierarchical branches are responsible for extracting feature maps with different sizes of receptive fields and fusing these feature maps with the features extracted from the trunk branches to achieve multi‐scale feature learning, which the authors refer to this design as the multi‐scale fusion block (MSFB). Extra enhancement information (EIE) is added to each EPAB input, which enables the backbone branch to learn more effectively. On the other hand, the outputs of the cascade branches are further complemented by an additional feedback fusion enhancement block (FFEB) before being fused with the output of the trunk branches to achieve more comprehensive and accurate feature learning. Numerous experiments have shown that MFFN achieves higher accuracy than other state‐of‐the‐art methods on benchmark test sets.
A single‐layered balanced filtering crossover with high selectivity based on square patch resonator
Authors: Li Yi , Wang Jianpeng , Zhu Lei , Wu Wen
Published: September 2023

A new design of single‐layered balanced filtering crossover with high selectivity based on square patch resonator is proposed. Originated from the degenerate modes, that is, TM12 and TM21 on square patch resonators, the feasibility of intrinsic common‐mode (CM) suppression and channel isolation is conceived. For demonstration, a first‐order balanced crossover prototype is designed. Afterwards, to enhance selectivity, a square patch resonator is subtly divided into two identical parts and then introduced into the prototype. Hence, a balanced filtering crossover with a fifth‐order Chebyshev response is formed. Furthermore, stubs are deployed between adjacent patch resonators to introduce mixed couplings. Thus, two controllable transmission zeros are obtained, and better out‐of‐band suppression is achieved. Ultimately, the proposed crossover is fabricated and measured. High performance in terms of differential‐mode filtering response, in‐band CM suppression and channel isolation demonstrates the feasibility of the proposed method.
Study of methane carbonate conversion process in fixed catalyst layer in different membrane reactors
Authors: Ortikov Nurbek , Fayzullaev Normurot , Hamidov Davron , Buronov Firdavsiy
Published: September 2023

The work studied the characteristics of membrane catalysts in the reaction of methane carbonate conversion as a model reaction. This process produces synthesis gas (a 1:1 mixture of Н2and СО), which can be used to make many products, including synthetic fuels (in the FischerTropsch process). One of the serious problems of methane carbonate conversion is the presence of side reactions that prevent the production of synthesis gas with the required ratio of products (H2:CO=1:1).Membrane catalysts were investigated in carbonate conversion of methane and membrane catalytic reactors: extractor, contactor, and distributor. Carbonate conversion of methane was compared with their material performance characteristics in the ground state in a conventional catalytic reactor with a fixed catalyst bed on membrane catalysts in the contactor and distributor. As the main parameters of the process of catalytic methane carbonate conversion, the change of the main parameters of the process -the concentration of the components in the products, the degree of change of the initial reagents and the ratio of the resulting synthesis gas components, depending on the contact time - were considered. The work aims to study methane's carbonate conversion process in a fixed catalyst layer in different membrane reactors.
Thermodynamic evaluation of methane oxycondensation reaction
Authors: Fayzullaev Normurot , Tursunova Nargiza , Kurbanova Dilorom , Kholmirzayeva Khilola , Khafizova Nigina
Published: September 2023

In this article, factors affecting the rate of methane oxycondensation reaction, and kinetic laws of the reaction are studied in a flow differential reactor. Values of parallel and sequential reactions in the oxidative condensation of methane at different temperatures for methane conversion and product selectivity, equilibrium composition of oxidation condensation reaction components at different temperatures, based on the study of factors such as the rate of methane conversion into products at different temperatures, the reactions of the formation of ethane, ethylene, acetylene, carbon dioxide from methane were studied.
Fear Of Missing Out (FOMO) and Instagram Social Media Addiction Among Early Adulthood
Authors: Putri Uli Anisa Ghea , Hurriyati Evi Afifah , Hassanbasry Meitha Vallerie
Published: September 2023

The purpose of the research was to find out a relationship between fear of missing out (FOMO) and Instagram addiction in early adulthood. This research used quantitative methods and obtained a total of 220 early adult participants with an age range from 18-25 years old. Fear of missing out was measured by Przybylski’s FOMO Scale and Instagram Addiction was measured by The Instagram Addiction Scale. This research used correlational design as a data analysis technique. This research also used Spearman’s correlation which stated that there was a positive significant relationship between fear of missing out (FOMO) and Instagram addiction (rs =0.779, p<0.05). It can be concluded that there was a positive significant relationship between fear of missing out (FOMO) and Instagram addiction in early adulthood.
Enhancing Sustainable Rice Grain Quality Analysis with Efficient SVM Optimization Using Genetic Algorithm
Authors: Ramdhani Yudi , Alamsyah Doni Purnama
Published: September 2023

The most extensively cultivated and indispensable crops in agriculture, ensuring sustainable rice cultivation practices is crucial, and accurately determining rice grain quality is a critical component of this effort. To achieve this goal, researchers have developed a novel technique that combines Support Vector Machine classification with Genetic Algorithm optimization. Using this technique, they were able to categorize rice grain quality with 92.81% accuracy, which improved to 93.31% after optimizing feature weights and classification configurations using the Genetic Algorithm. Compared to other classification algorithms, SVM showed the highest accuracy value, while k-NN had the lowest accuracy of 88.32%. The study’s results suggest that the combination of SVM classification with Genetic Algorithm optimization is an effective method for accurately analyzing rice grain quality. Furthermore, the SVM-based method outperformed other commonly used classification algorithms in terms of accuracy. This study’s findings could be valuable in promoting sustainable rice cultivation practices by improving the accuracy and efficiency of rice grain quality analysis and enhancing the overall productivity of the rice cultivation process. To further improve the classification accuracy of rice grain quality, the researchers employed the Genetic Algorithm optimization method to refine the feature weights and classification configurations.
Gold and Cryptocurrency as Safe Haven Assets for Commodities, Stocks, and Bonds: Evidence from the Russia-Ukraine War
Authors: Amalina Hazrati Havidz Shinta , Indah Rahmadani Ni Putu , Laura Aditya Tori Priscilla
Published: September 2023

This research was conducted to determine whether gold and cryptocurrency (i.e., Bitcoin) can be used as safe haven assets for oil, wheat, stock index (SI), government bond (GB), Islamic stock (IS), and Islamic bond (IB) during the Russia-Ukraine war. We used panel quantile regression by utilizing extreme lower quantiles (i.e., 1%, 2.5%, 5%). It will only be recognized as a safe haven asset if it is negatively correlated with another asset during extreme adverse shocks. The data spans from 23 February 2021 – 25 July 2022 which covered the five largest economies in Europe and Asia (i.e., Germany, France, the UK, China, and Japan). The findings indicate that gold only acted as a safe haven asset for wheat, SI, and IS during the Russia-Ukraine war. Additionally, Bitcoin only serves as a safe haven asset for oil, wheat, SI, and GB during the Russia-Ukraine war.
Leveraging Generative AI Solutions in Art and Design Education: Bridging Sustainable Creativity and Fostering Academic Integrity for Innovative Society
Authors: Fathoni Ahmad Faisal Choiril Anam
Published: September 2023

Artificial intelligence (AI) has transformed art and design education, giving students new ways to create, explore, and learn. Unfortunately, there is fear among academicians that students will use AI, especially text-to-image generators like Midjourney or Dall-E, as an illegal shortcut in creating their work. This article examines how generative AI solutions, such as text-to-image generators, can help students create innovative and sustainable designs while promoting academic integrity. The article shows how AI in art and design education can equip students with the skills and knowledge to succeed in a rapidly changing digital landscape. This research uses a qualitative method by analyzing the apps and literature reviews in journals and documents related to the problems studied. Case studies show how AI-based solutions can help students create innovative and sustainable designs while promoting academic integrity. Integrating controlled AI- based approaches in art and design education can promote academic integrity, creativity, and sustainability. AI-based art and design education solutions may help society become more innovative and sustainable. This article concludes that art and design educators must embrace AI-based solutions to prepare students for a rapidly changing digital world.
The Impact of Artificial Intelligence on Accounting Education: A Review of Literature
Authors: Tandiono Rosaline
Published: September 2023

This study explores the impact of artificial intelligence (AI) on accounting education through a semi-systematic review of the literature. The review found findings from 20 studies on the topic of AI and accounting education published in various journals, conference proceedings, and a book chapter. The findings reveal that scholars have expressed concerns about the impact of AI on accounting education for a significant period. Moreover, several themes emerge, including an interest in expert systems, an exploration of the application of AI in accounting education, and the call for accounting curricular reform. The study concludes that accounting educators must adapt their teaching methods and curricula to ensure that graduates are equipped with the necessary skills for a changing industry. Future research can concentrate on enhancing accounting curricula with the latest technological advancements, like AI, and exploring its potential impacts on the accounting industry, including risks, limitations, ethical implications, and its usefulness in accounting practices like financial reporting and auditing.
Should Indonesia Block ChatGPT?
Authors: Shidarta  , Martinelli Imelda
Published: September 2023

The development of ChatGPT has raised so many concerns that several countries have banned it in their respective countries. Italy was the first Western country to deny it, albeit temporarily. Italy’s action has prompted OpenAI to improve the ChatGPT technology to ensure that it meets the standards of consumer protection, data protection, privacy, and public security standards, as set out in the General Data Protection Regulation for European Union countries. This move by Italy raises the question of whether Indonesia should also block ChatGPT. The authors answer this question by examining data on Internet usage, its penetration of Indonesian citizens, and recent developments in regulatory provision and implementation. From the bibliographic research, the authors state that Indonesia is in a different bargaining position than Italy, even though the number of Internet users in Indonesia is far greater. The authors conclude that Indonesia will only benefit from blocking ChatGPT by first improving digital literacy levels and building regional cooperation. Keywords: artificial intelligence, ChatGPT, personal data protection.
Comparison of Technology Transformation in Digital Leadership Indonesia and Malaysia in Era Society 5.0
Authors: Marion Elisa Carolina , Augtania Ajeng Yera
Published: September 2023

Society 5.0 is a concept that envisions integrating technology and society to address complex social challenges and enhance the quality of life. The essay examines the government’s support and vision for Society 5.0 in Malaysia and Indonesia regarding infrastructure development, the promotion of entrepreneurship and innovation, and the emphasis on education and skills development. It highlights Indonesia’s initiatives to embrace Society 5.0 by increasing human resources and public services competence while exploring Malaysia’s efforts to leverage technology for economic advancement. The analysis considers the challenges and opportunities in realizing the goals of Society 5.0 and emphasizes the importance of collaboration between government, industry, and citizens. Through a comparative lens, this essay aims to provide insights into the strategies employed by Indonesia and Malaysia in navigating the era of Society 5.0 and harnessing the potential of technology for the betterment of society. The result of this research found that reveals that both countries have undertaken significant efforts to implement digital technology transformation toward Society 5.0. While both countries strive to improve the quality of services and enhance the welfare and quality of life, Malaysia has achieved a higher level of optimization in its digital technology development than Indonesia.
Between Fair and Speedy Trial: E-Court During Pandemic and A Challenge in Society 5.0
Authors: Prahassacitta Vidya , Monica Anastasia
Published: September 2023

Indonesian authorities impose restrictions on community activities to control the spread of Covid-19 infection. It impacts the court activities, including the criminal trial process. Therefore, the Indonesia Supreme Court issued a regulation that imposed the electronic court process on a criminal trial to solve this situation. The research aims to analyze the implementation of electronic courts, especially in the criminal trial during the pandemic Covid-19 in Depok District Court. The research is qualitative with a socio-legal approach. Data collection is obtained through in-depth interviews and observation. The result shows that the court focused on a speedy trial. However, there is a lack of quality of a fair trial, and, subsequently, it harms the defendant’s rights. The electronic court will be widely used in society 5.0, where technology is highly used to integrate cyberspace and physical space. It requires a shifting paradigm from face-to-face contact to virtual contact. It becomes a challenge and may impact the decision-making process. Therefore, in the post-pandemic Covid-19 era, the court requires reviewing and improving the electronic court process, which provides the advanced technology to support the electronic trial and is more critical to guarantee access to a fair trial in the electronic court process.
Mushroom Mycelium-Based Biodegradable Packaging Material: A Promising Sustainable Solution for Food Industry
Authors: Pohan Jennifer Nathania , Kusumawati Yudhistya Ayu , Radhitanti Asri
Published: September 2023

It is undeniable that many environments and areas are still full of waste. What’s more, it’s increasing annually. With a growing era, the use of plastic has also increased, especially in online sales that involve plastic as a package protector. With 40% of plastic production going to the packaging sector, an environmentally friendly replacement would be helpful. Furthermore, plastic materials such as styrofoam are considered harmful to both environment and human health. Mycelium is one of the materials that are affordable and easy to obtain. It is a fungus part that can bind and form a strong material with the support of sawdust. With characteristics similar with polystyrene, society, especially MSMEs, is expected to use this material as a substitute.
Bioassay-Guided Fractionation and Biological Activity of Cardenolides from Streptocaulon juventas
Authors: Xu Yunhui , Xu Jian , Zhu Wanfang , Yan Yanling , Jiang Xueyang , Xie Zijian , Feng Feng , Zhang Jie
Published: September 2023

The discovery that Na/K-ATPase acts as a signal transducer led us to investigate the structural diversity of cardiotonic steroids and study their ligand effects. By applying Na/K-ATPase
activity assay-guided fractionation, we isolated a total of 20 cardiotonic steroids from Streptocaulon juventas, including an undescribed juventasoside B (10) and 19 known
cardiotonic steroids. Their structures have been elucidated. Using our platform of purified Na/K-ATPase and an LLC-PK1 cell model, we found that 10, at a concentration that induces
less than 10% Na/K-ATPase inhibition, can stimulate the Na/K-ATPase/Src receptor complex and selectively activate downstream pathways, ultimately altering prostate cancer cell growth. By
assessing the ligand effect of the isolated cardiotonic steroids, we found that the regulation of cell viability by the isolated cardiotonic steroids was not associated with their inhibitory
potencies against Na/K-ATPase activity but reflected their ligand-binding affinity to the Na/K-ATPase receptor. Based on this discovery, we identified a unique active cardiotonic steroid,
digitoxigenin (1), and verified that it can protect LLC-PK1 cells from hypoxic injury, implicating its potential use in ischemia/reperfusion injury and inducing collagen synthesis in
primary human dermal fibroblast cells, and implicating that compound 2 is the molecular basis of the wound healing activity of S. juventas.
Epidural Interlay Graft for Pituitary Surgery: A 4-Year Institutional Experience
Authors: Snyder Rita , Lee Sungho , Athukuri Prazwal , Ngo Emmeline Monique Tan , Fox Meha Goyal , Fakhri Samer , Takashima Masayoshi , Force Bahar Kapoor , Samson Susan Leanne , Gallagher Kathleen Kelly , Yoshor Daniel , Jalali Ali
Published: September 2023

Objective Sellar repair techniques with varying complexity and effectiveness have been employed to reduce the incidence of postoperative cerebrospinal fluid (CSF) leaks following endoscopic transsphenoidal pituitary surgery. This study describes our institutional experience with a minimalistic, highly effective approach to sellar repair.

Methods The authors performed a retrospective review of consecutive cases of transsphenoidal pituitary surgery performed at our institution. All included subjects underwent sellar repair with an epidural interlay graft. Relationships between patient and tumor characteristics, incidence of CSF leak, adjunct repair techniques, and endocrine outcomes were examined.

Results Three hundred and thirty-four (334) cases were included. Intraoperative CSF leak was encountered in 116 cases (34.7%), and postoperative CSF leak occurred only once (0.3%) early in the series. Seventy intraoperative CSF leaks were successfully repaired with an epidural interlay alone, including 13 high-flow leaks. Our rate of fat graft use (1.2%), nasoseptal flap (3.0%), and lumbar drain placement (6.6%) in the second half of the series showed a significant decline compared with the first half, indicating increased reliance on the interlay graft over time. Our 65% functional macroadenoma remission rate compares favorably with large historical series.

Conclusion Simple sellar repair using an epidural interlay graft is highly effective in preventing postoperative CSF leaks, including cases of high-flow intraoperative leaks. More complex repair techniques are reserved for select high-risk cases or those with inadequate sellar bony ledges. With this technique, there has been no postoperative CSF leak at our institution in over 300 consecutive transsphenoidal pituitary surgeries.
Implementation of a Short-term Treatment Protocol in Anemic Patients before Cardiac Surgery
Authors: Leviner Dror B. , Abraham Dana , Shiner Maayan , Schwartz Naama , Lavon Ophir , Sharoni Erez
Published: September 2023

Background We assessed whether implementation of an immediate preoperative treatment in anemic patients could result in fewer perioperative packed red blood cell (PRBC) transfusions and improved outcomes in a real-world setting.

Methods From January 1, 2020, to November 31, 2022, we implemented a perioperative protocol for anemic patients (hemoglobin (Hb) level in women <11.5 g/dL, men <12.5 g/dL), which included subcutaneous erythropoietin α, intravenous Iron, and intramuscular vitamin B12 (all given preoperatively) and per os iron and folic acid given once a day postoperatively. We retrospectively compared all patients receiving the protocol to all eligible patients who were operated upon in the 4 years prior to implementation of the protocol. Primary outcome was amount of PRBC transfusions during surgery and index admission.

Results In the months after protocol implementation, 114 patients who received the treatment protocol were compared with 236 anemic patients in the 4 years prior to who did not receive the protocol. The treatment reduced total PRBC use (control group median 4 [2–7] units vs. treatment 2 [1–3] units, p < 0.0001) and the incidence of postoperative blood products transfusions (treatment group 58 patients, 50.88% vs. control group 177 patients, 75%, p < 0.0001). Hb prior to discharge was higher among the protocol group (treatment median 9 g/dL [8.3–9.5 g/dL] vs. control 8.6 g/dL [8.1–9.1 g/dL], p = 0.0081).

Conclusion Despite some differences compared with previously described protocols, the implementation of a perioperative treatment protocol for anemic patients was associated with a reduction in PRBC transfusion in a real-world setting.
The Potential of Berberine to Target Telocytes in Rabbit Heart
Authors: Yang Min , Yang Tong , Mei Lu , Zhang Yingxing , Liang Chunhua , Bai Xuebing , Zhang Zhenwei , Shi Yonghong , Chen Qiusheng
Published: September 2023

A brand-new class of interstitial cells, called telocytes, has been detected in the heart. Telocytes can connect and transmit signals to almost all cardiomyocytes; this is highly
interrelated with the occurrence and development of heart diseases. Modern studies have shown that berberine has a therapeutic effect on cardiovascular health. However, berberineʼs mechanism
of action on the cardiovascular system through cardiac telocytes is unclear. Interestingly, 5 µm of berberine remarkably decreased the concentration of intracellular calcium and membrane
depolarization in cultured telocytes, upregulated the expression of CX43 and β-catenin, and downregulated the expressions of TRPV4 and TRPV1. Here, telocytes were identified in the
vascular adventitia and intima, endocardium, myocardium, adventitia, and heart valves. Moreover, telocytes were broadly dispersed around cardiac vessels and interacted directly through gap
junctions and indirectly through extracellular vesicles. Together, cardiac telocytes interact with berberine and then deliver drug information to the heart. Telocytes may be an essential
cellular target for drug therapy of the cardiovascular system.
Association between Benign Paroxysmal Positional Vertigo and Thyroid Diseases: Systematic Review and Meta-Analysis
Authors: Lima Cyntia Machado , Paiva Daniel Felipe Fernandes , Corona Ana Paula , Lessa Marcus Miranda
Published: September 2023

Introduction Benign paroxysmal positional vertigo (BPPV) is the peripheral vestibular dysfunction that most affects people worldwide, but its etiopathogenesis is still not fully understood. Considering the etiological diversity, some studies highlight the association between BPPV and thyroid diseases.

Objective To investigate the association between thyroid diseases and BPPV.

Data Synthesis Systematic review and meta-analysis of epidemiological studies searched in the PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases. Studies that were fully available and investigated the association between BPPV and thyroid diseases were selected. The articles that composed the meta-analysis were analyzed using the dichotomous model, the Mantel-Haenszel statistical test, odds ratio (OR), and a 95% confidence interval (CI). Of the 67 articles retrieved from the databases, 7 met the eligibility criteria of the systematic review, and 4 had data necessary to perform the meta-analysis. Qualitative analysis revealed that the studies were conducted in the European and Asian continents. The predominant methodological design was the case-control type, and thyroid dysfunctions, hypothyroidism, and Hashimoto thyroiditis occurred more frequently. The meta-analysis showed no association between hypothyroidism and BPPV; however, there was a statistically significant relationship between Hashimoto thyroiditis and BPPV.

Conclusion The meta-analysis results suggest a possible association between BPPV and Hashimoto thyroiditis. Nevertheless, we emphasize the need for further studies to elucidate the evidence obtained.
Rabson–Mendenhall Syndrome with Severe Insulin Resistance Type A: The Need to Act Faster than the Disease
Authors: Muammar Tawfik , Helal Radwa
Published: September 2023

Introduction Rabson–Mendenhall syndrome (RMS) is an autosomal disorder where severe insulin resistance is observed. Insulin levels decrease over time and suppress gluconeogenesis in the liver. Fatty acid oxidation is affected, leading to frequent episodes of ketoacidosis. The changes in RMS are much faster than in patients with type 2 diabetes. RMS patients have a significantly reduced life expectancy and may die during adolescence or early adulthood.

Case Presentation A 15-year-old girl presented with poorly controlled diabetes. She was diagnosed with RMS at the age of 50 days, and her genetic study showed a homozygous mutation for R141W in the INSR gene. Her insulin level was high at 737 μIU/mL, insulinoma antigen 2 and glutamic acid decarboxylase antibodies were negative, and C-peptide was > 18 ng/mL. There is a strong family history of RMS on her mother's side. Her hyperglycemia was treated with an insulin pump (requiring up to 300 units of insulin/day) and oral rosiglitazone for the first 6 years. Rosiglitazone was replaced by oral insulin-like growth factor 1 (IGF1). Over the last 3 years, she had four further episodes of diabetic ketoacidosis triggered by infections and severe lipodystrophy. A trial of leptin and subcutaneous IGF1 has failed. The patient has a closed-loop insulin pump MiniMed 780G with a total daily dose of 261 units (4.6 U/kg/day).

Results During the past 15 years, the patient suffered many health, psychological, family, and school issues. These issues were due to RMS itself, complications of diabetes, side effects of medications, and technology failure. Our multidisciplinary team tackled all issues by providing the most appropriate care, mediation, and technology.

Conclusion To act faster than the disease progression, we need to know the whole list of issues our patient could face, as this will help us to look at the entire picture rather than treating different pieces separately. Effective cooperation between the teams is crucial and needs to be organized through a family physician or by the team involved the most in patient care. Although technology has limitations, it still helps when used appropriately.
A Guide to Writing Case Series in Homeopathy: A Supplement to Part 2 of the Research Method Series
Authors: Dutta Abhijit
Published: September 2023

Writing a case series in homeopathy is a valuable endeavour that contributes to the advancement of knowledge and understanding within the field. This article serves as a concise guide providing essential insights on how to effectively compose case series in homeopathy. It highlights key considerations, including study design, case selection, data collection, analysis, manuscript preparation, ethical considerations, and addressed common misconceptions surrounding case series. By adhering to this guidance, homeopathic practitioners and researchers can document their clinical experiences, share valuable insights and contribute to the ongoing development of homeopathic practice.
Updates in Butterfly Graft Technique
Authors: Miller Jonas R. , Clark Joseph Madison
Published: September 2023

Nasal obstruction is a significant challenge greatly affecting individual quality of life. It is one of the most common presentations in the otolaryngology clinic, often persisting despite medical and, at times, surgical intervention. The butterfly graft has proven to be a veritable option addressing nasal valve collapse. Herein, we describe our most recent operative technique, highlight its application in ethnic rhinoplasty and revision cases, and discuss incorporation of dorsal preservation techniques in functional rhinoplasty.
Rare Case of Chronic Limb-Threatening Ischemia in a 32-Year-Old Patient with Nephrotic Syndrome: A Case Report
Authors: Afandy Jonathan Edbert , Taofan Taofan , Indriani Suci , Batubara Edwin Adhi Darmawan , Adiarto Suko
Published: September 2023

Chronic limb-threatening ischemia represents the end stage of peripheral artery disease (PAD), primarily affecting individuals over 60 years old. While quite rare, nephrotic syndrome (NS) is recognized for increasing the susceptibility to arterial thromboembolism (ATE). A 32-year-old male complained of resting pain in his left leg and pain after walking 50 meters with his right leg. He had a 9-year history of NS confirmed through biopsy and was on a daily regimen of 2 × 360 mg mycophenolic acid and 1 × 8 mg methylprednisolone. He had no history of hypertension, diabetes, or smoking. Atrophy and ulcers were observed on his left leg. Laboratory tests revealed elevated D-dimer and borderline high cholesterol levels. The right ankle-brachial index was 0.5, and for the left, it was 0.33. Computed tomography angiography identified occlusion in the left external iliac artery and right superficial femoral artery (SFA). The patient underwent percutaneous transluminal angioplasty with a plain balloon on both legs and an additional drug-eluting stent on the left SFA. He was discharged on rivaroxaban, clopidogrel, aspirin, simvastatin, mycophenolic acid, and methylprednisolone, with no complaints. The mechanism behind NS-caused ATE remains unclear, although it is associated with the loss of anticoagulants in urine, increased procoagulant activity, altered fibrinolytic systems, thrombocytosis, and enhanced platelet activation. Prolonged corticosteroid therapy in NS management also amplifies the risk of thromboembolism by promoting a hypercoagulable state. We suspected NS and the prolonged use of corticosteroids as risk factors for ATE, manifested as PAD in our patient. While optimal NS therapy may reduce the risk of PAD, prolonged corticosteroid use should be closely monitored.
New electronic implementation of the timestamps method intended for high resolution comparison of laser wavelengths
Authors: Diz-Bugarín Javier , Outumuro-González Ismael , Vázquez-Dorrío José Benito , Blanco-García Jesús , Valencia-Álvarez José Luis
Published: September 2023

This article describes a new measurement system for the comparison of two electronic signals of different frequencies with application to high resolution comparison of laser wavelengths using a Michelson interferometer. It was built within the framework of research projects made by the University of Vigo and the Laboratorio Oficial de Metroloxía de Galicia (LOMG) in cooperation with Escolas Proval High School. The new hardware is based on a cheap high-speed module for the acquisition of data and a microcontroller module for processing, which can also be used for practical lessons in vocational training. The system has been tested with electronic signal generators. The novel measurement method reduces the uncertainty using multiple consecutive measurements and the fractional part of the fringes and could achieve precisions in the range 10−12 of the wavelength ratios.