bluuebunny/crossref_metadata_2025 huggingface dataset:
Adhoc mobile power connectivity using a wireless power transmission grid
Authors: Gaire Pawan , Vital Dieff , Khan Md Rayhan , Chibane Cherif , Bhardwaj Shubhendu
Published: September 2021

Wireless charging of devices has significant outcomes for mobile devices, IoT devices and wearables. Existing technologies consider using Point to Point type wireless transfer from a transmitter Tx (node that is sending Power) to a receiver Rx (node that receives power), which limits the area of coverage for devices. As a result, existing systems are forced to use near field coupling to charge such devices. Fundamental limitation is also that such methods limit charging to a small hotspot. In partnership with Wireless Electrical Grid LANs (WiGL pronounced “wiggle”), we demonstrate patented Ad-hoc mesh networking method(s) to provide wireless recharging at over 5 feet from the source, while allowing significant lateral movement of the receiver on the WiGL (Wireless Grid LAN or local area network). The transmitter network method leverages a series of panels, operating as a mesh of transmitters that can be miniaturized or hidden in walls or furniture for an ergonomic use. This disruptive technology holds the unique advantage of being able to provide recharging of moving targets similar to the cellular concept used in WiLAN, as opposed to prior wireless charging attempts, which only allow a hotspot-based charging. Specifically, we demonstrate the charging of a popular smartphone using the proposed system in the radiating near field zone of the transmitter antennas, while the user is free to move in the space on the meshed network. The averaged received power of 10 dBm is demonstrated using 1W RF-transmitter(s), operating in the 2.4 GHz ISM band. The proposed hardware consists of antennas arrays, rectennas, power management and USB 2.0 interfaces for maintaining a voltage between 4.2 and 5.3 V and smooth charging. We also show extending the wireless grid coverage with the use of multiple transmitting antennas, and mechanical beam-steering even further an increased coverage using the proposed system.
Irinotecan and its metabolite SN38 inhibits procollagen I production of dermal fibroblasts from Systemic Sclerosis patients
Authors: Lapoirie J. , Tran L. , Piazza L. , Contin-Bordes C. , Truchetet M. E. , Bonnet F.
Published: September 2021

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by a microangiopathy and fibrosis of the skin and internal organs. No treatment has been proved to be efficient in case of early or advanced SSc to prevent or reduce fibrosis. There are strong arguments for a key role of topo-I in the pathogenesis of diffuse SSc. Irinotecan, a semisynthetic derivative of Camptothecin, specifically target topo-I. This study was undertaken to evaluate the effects of noncytotoxic doses of irinotecan or its active metabolite SN38 on collagen production in SSc fibroblasts. Dermal fibroblasts from 4 patients with SSc and 2 healthy donors were cultured in the presence or absence of irinotecan or SN38. Procollagen I release was determined by ELISA and expression of a panel of genes involved in fibrosis was evaluated by qRT-PCR. Subcytotoxic doses of irinotecan and SN38 caused a significant and dose-dependent decrease of the procollagen I production in dermal fibroblasts from SSc patients, respectively − 48 ± 3%, p < 0.0001 and − 37 ± 6.2%, p = 0.0097. Both irinotecan and SN38 led to a global downregulation of genes involved in fibrosis such as COL1A1, COL1A2, MMP1 and ACTA2 in dermal fibroblasts from SSc patients (respectively − 27; − 20.5; − 30.2 and − 30% for irinotecan and − 61; − 55; − 50 and − 54% for SN38). SN38 increased significantly CCL2 mRNA level (+ 163%). The inhibitory effect of irinotecan and its active metabolite SN38 on collagen production by SSc fibroblasts, which occurs through regulating the levels of expression of genes mRNA, suggests that topoisomerase I inhibitors may be effective in limiting fibrosis in such patients.
Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
Authors: Feng Gang , Han Wenhao , Shi Jinyan , Xia Rongrong , Xu Jianchun
Published: September 2021

Most Mycobacterium tuberculosis (Mtb) resistant to rifampicin (RIF) has mutations in the rpoB gene, while most Mtb resistant to isoniazid (INH) has mutations in the katG gene or inhA promoter. We used gene chip technology to detect mutations in these genes to determine the resistance of Mtb to RIF and INH. A total of 4148 clinical specimens with sputum smear positivity for acid-fast bacilli (AFB) were detected. Then, taking the results of the drug sensitivity test (DST) as the reference standard, the detection efficiency of sputum samples from different grades of positive smears was compared in detail. We found that the sensitivity of the gene chip method for detecting sputum samples with a grade ≥ AFB 2 + was higher than that of sputum samples with a grade ≤ AFB 1 + (P < 0.05). When the grade of the sample was ≤ AFB 1 +, the sensitivity of the gene chip method was 72.6% for RIF, 67.3% for INH, and 60.0% for MDR-TB. When the grade of the sample was ≥ AFB 2 +, the sensitivity of the gene chip method was 84.5% for RIF, 78.2% for INH, and 73.9% for MDR-TB. The results show that gene chip technology can be directly used to diagnose drug-resistant tuberculosis in clinical specimens, and the diagnostic efficiency for the detection of sputum specimens with a grade ≥ AFB 2 + is better than that of other sputum specimens.
Risk factors for periorbital dermatitis in patients using dorzolamide/timolol eye drops
Authors: Kim Myungjin , Jang Hyoju , Rho Seungsoo
Published: September 2021

This study assessed the clinical risk factors for periorbital dermatitis (PD) after using dorzolamide/timolol eye drops in a total of 1282 glaucoma patients. Both the PD(+) group and the PD(−) group were evaluated using clinical data such as age, sex, dosing duration, presence of benzalkonium chloride (BAK) in the formulation, ocular surgery history (e.g. cataract or glaucoma operations), height, weight, personal history of systemic hypertension, smoking, alcohol consumption, intraocular pressure, best-corrected visual acuity (BCVA), central corneal thickness, axial length, and visual field index (VFI). Univariate analyses showed that shorter dosing duration, higher rate of BAK-included cases, worse BCVA, worse VFI, more systemic hypertension history, and more ocular surgery history were more associated with the PD(+) group than the PD(−) group. The BAK(−) group showed a lower PD rate than the BAK-included group, which was supported by the Kaplan–Meier analysis (log-rank test, p = 0.0014). Multivariate analyses revealed that the probability of PD increased by 8 times if they had a history of ocular surgery and increased by 2.3% when the VFI decreased by 1% (Cox’s hazard regression test, p < 0.001). Therefore, a preservative-free dorzolamide/timolol can benefit the subjects for those who had ocular surgery or who have worse VFI.
The effect of population size for pathogen transmission on prediction of COVID-19 spread
Authors: Zhang Xuqi , Liu Haiqi , Tang Hanning , Zhang Mei , Yuan Xuedong , Shen Xiaojing
Published: September 2021

Extreme public health interventions play a critical role in mitigating the local and global prevalence and pandemic potential. Here, we use population size for pathogen transmission to measure the intensity of public health interventions, which is a key characteristic variable for nowcasting and forecasting of COVID-19. By formulating a hidden Markov dynamic system and using nonlinear filtering theory, we have developed a stochastic epidemic dynamic model under public health interventions. The model parameters and states are estimated in time from internationally available public data by combining an unscented filter and an interacting multiple model filter. Moreover, we consider the computability of the population size and provide its selection criterion. With applications to COVID-19, we estimate the mean of the effective reproductive number of China and the rest of the globe except China (GEC) to be 2.4626 (95% CI: 2.4142–2.5111) and 3.0979 (95% CI: 3.0968–3.0990), respectively. The prediction results show the effectiveness of the stochastic epidemic dynamic model with nonlinear filtering. The hidden Markov dynamic system with nonlinear filtering can be used to make analysis, nowcasting and forecasting for other contagious diseases in the future since it helps to understand the mechanism of disease transmission and to estimate the population size for pathogen transmission and the number of hidden infections, which is a valid tool for decision-making by policy makers for epidemic control.
Optical versus electron diffraction imaging of Twist-angle in 2D transition metal dichalcogenide bilayers
Authors: Psilodimitrakopoulos S. , Orekhov A. , Mouchliadis L. , Jannis D. , Maragkakis G. M. , Kourmoulakis G. , Gauquelin N. , Kioseoglou G. , Verbeeck J. , Stratakis E.
Published: September 2021

Atomically thin two-dimensional (2D) materials can be vertically stacked with van der Waals bonds, which enable interlayer coupling. In the particular case of transition metal dichalcogenide (TMD) bilayers, the relative direction between the two monolayers, coined as twist-angle, modifies the crystal symmetry and creates a superlattice with exciting properties. Here, we demonstrate an all-optical method for pixel-by-pixel mapping of the twist-angle with a resolution of 0.55(°), via polarization-resolved second harmonic generation (P-SHG) microscopy and we compare it with four-dimensional scanning transmission electron microscopy (4D STEM). It is found that the twist-angle imaging of WS2 bilayers, using the P-SHG technique is in excellent agreement with that obtained using electron diffraction. The main advantages of the optical approach are that the characterization is performed on the same substrate that the device is created on and that it is three orders of magnitude faster than the 4D STEM. We envisage that the optical P-SHG imaging could become the gold standard for the quality examination of TMD superlattice-based devices.
Artificial intelligence sepsis prediction algorithm learns to say “I don’t know”
Authors: Shashikumar Supreeth P. , Wardi Gabriel , Malhotra Atul , Nemati Shamim
Published: September 2021

Sepsis is a leading cause of morbidity and mortality worldwide. Early identification of sepsis is important as it allows timely administration of potentially life-saving resuscitation and antimicrobial therapy. We present COMPOSER (COnformal Multidimensional Prediction Of SEpsis Risk), a deep learning model for the early prediction of sepsis, specifically designed to reduce false alarms by detecting unfamiliar patients/situations arising from erroneous data, missingness, distributional shift and data drifts. COMPOSER flags these unfamiliar cases as indeterminate rather than making spurious predictions. Six patient cohorts (515,720 patients) curated from two healthcare systems in the United States across intensive care units (ICU) and emergency departments (ED) were used to train and externally and temporally validate this model. In a sequential prediction setting, COMPOSER achieved a consistently high area under the curve (AUC) (ICU: 0.925–0.953; ED: 0.938–0.945). Out of over 6 million prediction windows roughly 20% and 8% were identified as indeterminate amongst non-septic and septic patients, respectively. COMPOSER provided early warning within a clinically actionable timeframe (ICU: 12.2 [3.2 22.8] and ED: 2.1 [0.8 4.5] hours prior to first antibiotics order) across all six cohorts, thus allowing for identification and prioritization of patients at high risk for sepsis.
Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
Authors: Malkov Anton , Popova Irina , Ivanov Anton , Jang Sung-Soo , Yoon Seo Yeon , Osypov Alexander , Huang Yadong , Zilberter Yuri , Zilberter Misha
Published: September 2021

A predominant trigger and driver of sporadic Alzheimer’s disease (AD) is the synergy of brain oxidative stress and glucose hypometabolism starting at early preclinical stages. Oxidative stress damages macromolecules, while glucose hypometabolism impairs cellular energy supply and antioxidant defense. However, the exact cause of AD-associated glucose hypometabolism and its network consequences have remained unknown. Here we report NADPH oxidase 2 (NOX2) activation as the main initiating mechanism behind Aβ1-42-related glucose hypometabolism and network dysfunction. We utilize a combination of electrophysiology with real-time recordings of metabolic transients both ex- and in-vivo to show that Aβ1-42 induces oxidative stress and acutely reduces cellular glucose consumption followed by long-lasting network hyperactivity and abnormalities in the animal behavioral profile. Critically, all of these pathological changes were prevented by the novel bioavailable NOX2 antagonist GSK2795039. Our data provide direct experimental evidence for causes and consequences of AD-related brain glucose hypometabolism, and suggest that targeting NOX2-mediated oxidative stress is a promising approach to both the prevention and treatment of AD.
Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
Authors: Bock Lucy J. , Ferguson Philip M. , Clarke Maria , Pumpitakkul Vichayanee , Wand Matthew E. , Fady Paul-Enguerrand , Allison Leanne , Fleck Roland A. , Shepherd Matthew J. , Mason A. James , Sutton J. Mark
Published: September 2021

Pseudomonas aeruginosa is an opportunistic pathogen capable of stably adapting to the antiseptic octenidine by an unknown mechanism. Here we characterise this adaptation, both in the laboratory and a simulated clinical setting, and identify a novel antiseptic resistance mechanism. In both settings, 2 to 4-fold increase in octenidine tolerance was associated with stable mutations and a specific 12 base pair deletion in a putative Tet-repressor family gene (smvR), associated with a constitutive increase in expression of the Major Facilitator Superfamily (MFS) efflux pump SmvA. Adaptation to higher octenidine concentrations led to additional stable mutations, most frequently in phosphatidylserine synthase pssA and occasionally in phosphatidylglycerophosphate synthase pgsA genes, resulting in octenidine tolerance 16- to 256-fold higher than parental strains. Metabolic changes were consistent with mitigation of oxidative stress and altered plasma membrane composition and order. Mutations in SmvAR and phospholipid synthases enable higher level, synergistic tolerance of octenidine.
Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population
Authors: Wu Chia-Hsin , Hsieh Chia-Shan , Chang Yo-Cheng , Huang Chi-Cheng , Yeh Hsien-Tang , Hou Ming-Feng , Chung Yuan-Chiang , Tu Shih-Hsin , Chang King-Jen , Chattopadhyay Amrita , Lai Liang-Chuan , Lu Tzu-Pin , Li Yung-Hua , Tsai Mong-Hsun , Chuang Eric Y.
Published: September 2021

Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis of WGD and its influence on breast cancer subtypes in patients from Taiwan and consequently highlight the genomic association between WGD and homologous recombination deficiency (HRD). A higher manifestation of WGD was reported in triple-negative breast cancer, conferring high chromosomal instability (CIN), while HER2 + tumors exhibited early WGD events, with widely varied CIN levels, compared to luminal-type tumors. An association of higher activity of de novo indel signature 2 with WGD and HRD in Taiwanese breast cancer patients was reported. A control test between WGD and pseudo non-WGD samples was further employed to support this finding. The study provides a better comprehension of tumorigenesis in breast cancer subtypes, thus assisting in personalized treatment.
Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
Authors: Rajab Suhaila , Bismin Leah , Schwarze Simone , Pinggera Alexandra , Greger Ingo H. , Neuweiler Hannes
Published: September 2021

Ionotropic glutamate receptors (iGluRs) mediate signal transmission in the brain and are important drug targets. Structural studies show snapshots of iGluRs, which provide a mechanistic understanding of gating, yet the rapid motions driving the receptor machinery are largely elusive. Here we detect kinetics of conformational change of isolated clamshell-shaped ligand-binding domains (LBDs) from the three major iGluR sub-types, which initiate gating upon binding of agonists. We design fluorescence probes to measure domain motions through nanosecond fluorescence correlation spectroscopy. We observe a broad kinetic spectrum of LBD dynamics that underlie activation of iGluRs. Microsecond clamshell motions slow upon dimerization and freeze upon binding of full and partial agonists. We uncover allosteric coupling within NMDA LBD hetero-dimers, where binding of L-glutamate to the GluN2A LBD stalls clamshell motions of the glycine-binding GluN1 LBD. Our results reveal rapid LBD dynamics across iGluRs and suggest a mechanism of negative allosteric cooperativity in NMDA receptors.
Estimation of the orientation of stress in the Earth’s crust without earthquake or borehole data
Authors: Delorey Andrew A. , Bokelmann Götz H. R. , Johnson Christopher W. , Johnson Paul A.
Published: September 2021

Mechanical stress acting in the Earth’s crust is a fundamental property that is important for a wide range of scientific and engineering applications. The orientation of maximum horizontal compressive stress can be estimated by inverting earthquake source mechanisms and measured directly from borehole-based measurements, but large regions of the continents have few or no observations. Here we present an approach to determine the orientation of maximum horizontal compressive stress by measuring stress-induced anisotropy of nonlinear susceptibility, which is the derivative of elastic modulus with respect to strain. Laboratory and Earth experiments show that nonlinear susceptibility is azimuthally dependent in an anisotropic stress field and is maximum in the orientation of maximum horizontal compressive stress. We observe this behavior in the Earth—in Oklahoma and New Mexico, U.S.A, where maximum nonlinear susceptibility coincides with the orientation of maximum horizontal compressive stress measured using traditional methods. Our measurements use empirical Green’s functions and solid-earth tides and can be applied at different temporal and spatial scales.
Chiral porous CN-bridged coordination polymer mimicking MOF-74 and showing magnetization photoswitching
Authors: Magott Michał , Pinkowicz Dawid
Published: September 2021

The cyanide-bridged coordination polymer mimics the topology and porosity of MOF-74. It also shows additional highly desired functionalities: chirality and photomagnetic effect, which makes it a truly multifunctional molecular material.
Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges
Authors: Wong Si Nga , Chen Yu Chee Sonia , Xuan Bianfei , Sun Changquan Calvin , Chow Shing Fung
Published: September 2021

This highlight presents an overview of pharmaceutical cocrystal production and its potential in reviving problematic properties of drugs in different dosage forms. The challenges and future outlook of its translational development are discussed.
First hyperpolarizability of water at the air–vapor interface: a QM/MM study questions standard experimental approximations
Authors: Le Breton Guillaume , Bonhomme Oriane , Brevet Pierre-François , Benichou Emmanuel , Loison Claire
Published: September 2021

The first hyperpolarizability of a water molecule at the liquid–vapor interface differs from its counterparts in the bulk vapor or liquid phase.
Distinct molecular dynamics dividing liquid-like and gas-like supercritical hydrogens
Authors: Yamaoka Shutaro , Hyeon-Deuk Kim
Published: September 2021

By finding that intramolecular properties and smearing dynamics of a solvation shell exhibit the anomalous order crossing the Widom line, we demonstrated that a supercritical fluid is a mixture of liquid and gas possessing heterogeneity.
Molecular magnetism in nanodomains of isoreticular MIL-88(Fe)-MOFs
Authors: Dawood Sheeba , Shaji Surabhi , Pathiraja Gayani , Mo Yirong , Rathnayake Hemali
Published: September 2021

Molecular magnetism in nanodomains of isoreticular MIL-88(Fe)-MOFs is demonstrated, revealing phase transition from ferromagnetism to short range ordering of superparamagnetic state.
Polymer solubility in ionic liquids: dominated by hydrogen bonding
Authors: Yuan Ya-Fei , Zhang Jin-Ming , Zhang Bao-Qing , Liu Jia-Jian , Zhou Yan , Du Ming-Xuan , Han Lin-Xue , Xu Kuang-Jie , Qiao Xin , Liu Chen-Yang
Published: September 2021

The product of H-bond acidity (α) and basicity parameter (β) reflects the complementary nature of the H-bonding interactions. Strong cross-association and weak self-association favor the solubility of polymer in ILs, therefore the product of ΔαΔβ< 0.
DNA origami nano-mechanics
Authors: Ji Jiahao , Karna Deepak , Mao Hanbin
Published: September 2021

We re-examine DNA origami nanoassemblies from four fundamental mechanical aspects of elasticity, pliability, plasticity and stability.
Rapid detection strategies for the ultra-level chemosensing of uranyl ions
Authors: Kumar R Selva , Venkatesan Vetriarasu , Bhaskar R. , Kumar S. K. Ashok , Sivaramakrishna Akella , Vijayakrishna Kari , Brahmmananda Rao C. V. S. , Sivaraman N. , Sahoo Suban K.
Published: September 2021

Developed a new ligand (L) for the selective detection of UO22+. The sensitivity of L is recognized by LOD and it is as 20 ppb. The smartphone integrated RGB model and testing paper kit are portable tools for the on-site testing applications.
Luminescent halido(aryl) Pt(iv) complexes obtainedviaoxidative addition of iodobenzene or diaryliodonium salts to bis-cyclometalated Pt(ii) precursors
Authors: López-López Juan-Carlos , Bautista Delia , González-Herrero Pablo
Published: September 2021

The oxidative addition of iodobenzene or diaryliodonium salts to bis-cyclometalated Pt(ii) precursors provides access to luminescent halido(aryl) Pt(iv) complexes. The introduction of fluoride results in shorter emission lifetimes.
Chlorinated solvent degradation in groundwater by green rust–bone char composite: solute interactions and chlorinated ethylene competition
Authors: Ai Jing , Tobler Dominique J. , Duncan-Jones Cecilie Gry , Manniche Maria Eckardt , Andersson Kirstine Evald , Hansen Hans Christian B.
Published: September 2021

Potential inhibitors in the groundwater matrix that affect bone char (BC) mediated dechlorination of chlorinated ethylenes by green rust (GR).
Catalase-driven protein microtube motors with different exterior surfaces as ultrasmall biotools
Authors: Umebara Mizuki , Sugai Natsuho , Murayama Kohei , Sugawara Tomonao , Akashi Yushi , Morita Yoshitsugu , Kato Ryo , Komatsu Teruyuki
Published: September 2021

We report the synthesis of catalase-driven protein microtube motors with different exterior surfaces. Their abilities of bacteria capture, reaction enhancement by self-stirring, and velocity control with light irradiation were highlighted.
Synthesis of bicyclic vinyl triazenes by Ficini-type reactions
Authors: Bormann Carl Thomas , Fadaei-Tirani Farzaneh , Scopelliti Rosario , Severin Kay
Published: September 2021

Cyclobutenyl triazenes are obtained by Lewis acid-catalyzed [2 + 2] cycloaddition reactions of 1-alkynyl triazenes and enones. The triazene group in the product enables rearrangements and functionalizations.
Alginate-based diblock polymers: preparation, characterization and Ca-induced self-assembly
Authors: Solberg Amalie , Mo Ingrid V. , Aachmann Finn L. , Schatz Christophe , Christensen Bjørn E.
Published: September 2021

Renewable resources can provide a range of different polysaccharide blocks that can be used to prepare new types of stimuli-responsive polysaccharide-based block copolymers.
Thermal stability of nitride phosphors for light-emitting diodes
Authors: Tian Junhang , Zhuang Weidong
Published: September 2021

Improving thermal stability of nitride phosphors has become an important material challenge. Our review describes three thermal phenomena, lists strategies for enhancing thermal stability of nitride phosphors, and discusses prospects in the future.
Catalytic hydrogenolysis of larix bark proanthocyanidins in ionic liquids produces UV blockers with potential for use in cosmetics
Authors: Zhou Meng , Chen Xiaoxia , Gao Chong , Ni Liwen , Wang Xuechun , Zhang Wudi , Ren Shixue
Published: September 2021

Oligomeric proanthocyanidins with excellent UV resistance were prepared by hydrogenolysis in ionic liquids.
Switching of alternative electrochemical charging mechanism inside single-walled carbon nanotubes: a quartz crystal microbalance study
Authors: Al-zubaidi Ayar , Takahashi Mikako , Ishii Yosuke , Kawasaki Shinji
Published: September 2021

The increase in charge carrier density in SWCNTs with applied potential overcomes steric hindrance to counter-ion adsorption by switching the dominant charge storage mechanism to co-ion desorption.
Chromophore-radical excited state antiferromagnetic exchange controls the sign of photoinduced ground state spin polarization
Authors: Kirk Martin L. , Shultz David A. , Hewitt Patrick , Stasiw Daniel E. , Chen Ju , van der Est Art
Published: September 2021

A change in the sign of the ground state electron spin polarization (ESP) is reported in complexes where an organic radical (nitronylnitroxide, NN) is covalently attached to a donor–acceptor chromophoreviatwo differentmeta-phenylene bridges.
Citrate-based mussel-inspired magnesium whitlockite composite adhesives augmented bone-to-tendon healing
Authors: Yuan Xiaowei , Zhao Yitao , Li Jintao , Chen Xuncai , Lu Zhihui , Li Lianyong , Guo Jinshan
Published: September 2021

Citrate-based mussel-inspired magnesium whitlockite composite adhesives were developed to augment bone-to-tendon healing, by providing interface adhesion, promoting bony inward growth from the bone tunnel, and enhancing chondrogenesis and osteogenesis of the bone–tendon interface.
Significantly enhanced thermal stability from a new kind of n-type organic semiconductor DFA4: a fully fused F8IC
Authors: Duan Tainan , Wu Yangjiang , Yang Ke , Oh Jiyeon , Yang Changduk , Chen Shanshan , Zhong Cheng , Yu Donghong , Zhao Yan , Lu Shirong
Published: September 2021

A new n-type organic semiconductor (DFA4) that features a fully-fused tetradecyl cyclic π-backbone was designed and synthesized. OFET and OPV devices based on DFA4 were fabricated and characterized, respectively.
Intelligent fitting global real‐time task scheduling strategy for high‐performance multi‐core systems
Authors: Wu Junpeng , Zhao Enyuan , Li Sizhao , Wang Yanqiang
Published: September 2021

With the development of high‐performance computing, it is possible to solve large‐scale computing problems. However, the irregularity and access characteristics of computing problems bring challenges to the realisation and performance optimisation. Improving the performance of a single core makes it challenging to maintain Moore's law, and multi‐core processors emerge. A chip brings together multiple universal processor cores of equal status and has the same structure supported by an isomorphic multi‐core processor. In high‐performance computing, the granularity of computing tasks leads to the complexity of scheduling strategies. Satisfying high system performance, load balancing and processor fault tolerance at a minimum cost is the key to task scheduling in the high‐performance field, especially in specific multi‐core hardware architecture. In this study, global real‐time task scheduling is implemented in a high‐performance multi‐core system. The system adopts the hybrid scheduling among clusters and the intelligent fitting within clusters to implement the global real‐time task scheduling strategy. In the cluster scheduling policy, tasks are allowed to preempt the core with low priority, and the priority of tasks that access memory is dynamically improved, higher than that of all the tasks without memory access. An intelligent fitting method is also proposed. When the data read by the task is in the cache and the cache access ability value of the task is within a reasonable threshold, the priority of the task is promoted to the highest priority, preempting the core without the access memory task. The results show that the intelligently fitting global scheduling strategy for multi‐core systems has better performance in the nuclear utilisation rate and task schedulability.
If you like C/O variations, you should have put a ring on it
Authors: van der Marel Nienke , Bosman Arthur D. , Krijt Sebastiaan , Mulders Gijs D. , Bergner Jennifer B.
Published: September 2021

Context. The C/O ratio as traced with C2H emission in protoplanetary disks is fundamental for constraining the formation mechanisms of exoplanets and for our understanding of volatile depletion in disks, but current C2H observations show an apparent bimodal distribution that is not well understood, indicating that the C/O distribution is not described by a simple radial dependence.

Aims. The transport of icy pebbles has been suggested to alter the local elemental abundances in protoplanetary disks through settling, drift, and trapping in pressure bumps, resulting in a depletion of volatiles in the surface layer and an increase in the elemental C/O.

Methods. We combine all disks with spatially resolved ALMA C2H observations with high-resolution continuum images and constraints on the CO snow line to determine if the C2H emission is indeed related to the location of the icy pebbles.

Results. We report a possible correlation between the presence of a significant CO-ice dust reservoir and high C2H emission, which is only found in disks with dust rings outside the CO snow line. In contrast, compact dust disks (without pressure bumps) and warm transition disks (with their dust ring inside the CO snow line) are not detected in C2H, suggesting that such disks may have never contained a significant CO ice reservoir.

Conclusions. This correlation provides evidence for the regulation of the C/O profile by the complex interplay of CO snow line and pressure bump locations in the disk. These results demonstrate the importance of including dust transport in chemical disk models for a proper interpretation of exoplanet atmospheric compositions and a better understanding of volatile depletion in disks, in particular the use of CO isotopologs to determine gas surface densities.
Research on the effect of industrial policy on the development of China’s new energy vehicle power battery recycling industry chain
Authors: Shuang Qiao , Yingqi Liu , Lei Zhang
Published: September 2021

With the increasing attention to ecological environmental protection and the rapid consumption of global energy resources, the new energy vehicle industry is attracting more and more attention from all over the world, and the vehicle power battery has ushered in the stage of mass scrapping. China's power battery recycling industry is in the primary stage of development. In order to analyze the impact of relevant industrial policies on the development of the industry chain, this paper describes the development status of the power battery recycling industry by drawing the panorama of the industry chain of power battery recycling. At last, the industrial policy of power battery recycling was evaluated qualitatively and quantitatively by analytic hierarchy process, and on this basis, some policy suggestions to promote the development of industrial chain were put forward.
Numerical Simulation Research on the Interactive Propagation of Hydraulic Fractures and Natural Fractures
Authors: Asiri Waleed Abdullah I , Xiaoming Ma
Published: September 2021

In order to study the fracture propagation behavior after the interaction between hydraulic fractures and natural fractures, the cohensive unit of Abaqus finite element software is used to simulate the influence of natural fractures in the rock on the propagation behavior of hydraulic fractures. The simulation results show that when the approach angle is kept constant, as the in-situ stress difference increases, hydraulic fractures are more likely to penetrate the natural fractures and expand along the direction of the maximum horizontal principal stress; while the stress difference remains the same, as the approach angle increases, hydraulic fractures are easier to penetrate natural fractures and expand along the direction of maximum horizontal principal stress. When the approach angle is kept constant, as the tensile strength of natural fractures increases, hydraulic fractures are more likely to penetrate the natural cracks and expand along the direction of the maximum horizontal principal stress; while the tensile strength of natural cracks remains unchanged, as the approach angle increases, the probability of forming a complex fracture network between hydraulic fractures and natural fractures is reduced, and it is easier to penetrate the natural fractures and expand along the direction of the maximum horizontal principal stress.
Effect evaluation and influencing factors of stratified water injection in low permeability reservoir
Authors: Bai Xin , Hao Shiyan , Guo Chunfen , Yao Shenglin
Published: September 2021

The main production layers in Danba oil area of Yanchang oilfield are Chang 4 + 5 and Chang 6 oil layers, which are the main development areas for increasing reserves and production. In view of the unclear influencing factors of water injection effect and the disunity of effect evaluation in the study area, the stratified water injection effect evaluation and influencing factors of low permeability reservoir are studied by means of production data statistical analysis and numerical simulation. The results show that the effect of water injection in the study area is affected by five factors: intraformational heterogeneity, interlayer heterogeneity, interlayer pressure difference, fracture and water injection timing, the results show that the water injection effect is obvious in the study area by using the five indexes of water drive reserves producing degree, water storage rate, water drive index, oil recovery rate and water drive control degree. The research results provide ideas for the study of high-efficiency separate layer water injection in low permeability reservoir, and provide guidance for the next step of potential mining.
Research and Application of Power Engineering Science and Technology Project Management Based on All Life-cycle
Authors: Chen Yingcui , Xie Wangyuan , Yu Xinru , Wu Chao
Published: September 2021

The electric power industry is an important chain in the energy revolution and one of the most important basic industries. At the same time, it is also facing the technology collision and industry innovation brought by various emerging technologies, which constantly promotes the development of the electric power industry in the direction of safety, intelligence and cleanness. Power grid enterprises have a great demand for scientific research and innovation, and the average annual investment in scientific research has exceeded 100 million yuan. With the increasing investment in scientific research and development of power enterprises year by year, the demand for systematic, scientific and efficient management system for scientific and technological projects is becoming increasingly urgent. In view of the shortcomings of the traditional project management mode, this study establishes the corresponding management and evaluation mechanism by combining with the whole life cycle management method of modern project management, realizes the transformation of power enterprise science and technology project management to high efficiency, high quality, specialization and scientization, and promotes the innovation and integration development of traditional technology and emerging technology. The all life-cycle management mode has been widely applied in major power grid projects. By integrating superior resources, breaking through major engineering technology research and development, giving full play to the innovation of projects and avoiding research and development risks, it explores the development direction of science and technology project management in energy industry and improves the industry management level.
Stress sensitivity evaluation of ultra-low permeability sandstone reservoir and its influence on oilfield development
Authors: Bai Xin , Guo Chunfen , Yang Xingli , Liu Xi
Published: September 2021

Luohe ultra-low permeability sandstone reservoir is a hot block in Yanchang oilfield, which is a potential point for increasing production and reservoir. In view of the current situation that there is no unified stress sensitivity evaluation standard for ultra-low permeability sandstone in the study area, taking the ultra-low permeability sandstone in Luohe district as the research object, the stress sensitivity evaluation of ultra-low permeability sandstone is carried out by using experimental analysis as the main means. The results show that it is more accurate to evaluate porosity by using pore stress sensitivity coefficient instead of pore compressibility coefficient. With the increase of net overburden pressure, the porosity stress sensitivity decreases gradually; the permeability stress sensitivity is evaluated by variable confining pressure. With the increase of confining pressure, the permeability damage decreases. With the decrease of confining pressure, the permeability damage increases, but it can not recover to the original value, so the permeability damage is irreversible; in the low bottom hole pressure stage, stress sensitivity has a greater impact on oil well productivity, while in the high bottom hole pressure stage, stress sensitivity has a smaller impact on oil well productivity; advanced water injection can reduce the adverse effect of stress sensitivity on the development of ultra-low permeability sandstone and maximize the economic benefits. The research results clarify the method of stress sensitivity evaluation, and provide guidance for efficient water injection in the next step.
Research on Electric-Vehicle Switching Scheduling and Charging Strategy of Charging Stations
Authors: Li Yuxing , Wu Hao , Shi Yu , Li Hao , Gao Xuefeng , Zhu Yeyang
Published: September 2021

In order to effectively alleviate the congestion of power exchange stations, the game theory was used to discuss the spatial characteristics of electric vehicle power exchange demand, analyze the decision making and game process of electric vehicle users specifically. Moreover, on the basis of the research, the specific way of setting the price of the exchange station was proposed and the game mathematical model was constructed.
Application of average pressure method in locating partial blockage of gas pipeline
Authors: Zhou Yang , Huang Ganggang , Wang Yong
Published: September 2021

In this paper, the applicability of average pressure method in the localization of partial blockage of gas pipeline was studied. It was proposed to transform the localization of partial blockage into a parameter optimization problem. Three optimization algorithms of PSO, GA and SAA were used to analyze the working conditions of 10 groups of laboratory experiments. The result shows that the combination of average pressure method and optimization algorithm has a strong propert in this location problem.
A Study on the Application of Video Assistant Referee (VAR) Technology in Chinese Football Professional League
Authors: Zhiliang Jia
Published: September 2021

By using the methods of literature review, video, video analysis and mathematical statistics, this paper studied the application of VAR technology in 30 rounds and 240 matches in Chinese super league in 2019, and compared it with Super League and 2018 FIFA world cup in 2018. It was found that the accuracy of key penalty was improved, the fairness and justice of the match were guaranteed, and the sound development of Super League was promoted. The application of VAR technology improved the trust between referees and players, promoted the self-confidence of referees in law enforcement and promoted the normal play of players' level. Shortcomings include unreasonable limits and timing of VAR intervention; the understanding and scale of foul penalty are not uniform; the review time is too long and the operation procedure is not standardized, etc. need to be improved.
Heterogeneity of Top Management Team and Earnings Management: An Empirical Analysis of A-Share Listed Companies during 2010-2017
Authors: Kou Mian
Published: September 2021

The behavior of corporate earnings management is an important factor restricting the development of the industry. Based on the senior echelon theory, TMT’s demographic characteristics such as the cognitive basis, observation, values and other characteristics, affect their strategic decisions, and thus affect the company’s performance and development of the industry. This paper selected 3588 listed companies from 2010-2017 using the revised Jones model to measure the earnings management degree of listed companies, and analyzed the impact of senior management team members on enterprise earnings management in three dimensions of age, education level and professional background. The study found there is no obvious correlation between the age heterogeneity of TMT and the degree of earnings management; the heterogeneity of the education level and the heterogeneity of professional background have a significant negative correlation with the degree of earnings management. This study can improve the corporate governance structure, promote the reform of the market supervision mechanism, protect the rights and interests of investors, and then promote the healthy development of the industry.
Discussion on the Design of Food Safety Subject Database Based on Big Data Testing
Authors: Chen Kai , Tao Heng , Yu Jie , Hao Miao , Yang Hong , Wang Yajie
Published: September 2021

Food safety is a matter of national importance, and it is important to establish and improve a whole process food safety supervision system with high standard. Along with the advent of the era of big data, to achieve this goal requires not only the reform and optimization of the old regulatory approach needs to establish the idea of information-based supervision, and actively apply big data technology to food safety testing. In this paper, we introduce the current situation of food safety in society, analyse the shortcomings of current food safety supervision and the challenges faced in the era of big data, discuss the feasibility of using big data for food safety testing with big data technology as the core, and give the design idea of establishing a corresponding food safety subject database. This paper takes food safety testing as the foothold and innovatively combines big data with food safety testing, with a view to providing reference for food safety regulatory authorities and promoting the healthy development of the food industry.
Value Evaluation of Moutai Group Based on FCFF Model
Authors: Wang Jinlong , Cai Shulong , Xu Yan
Published: September 2021

As the stock with the highest stock price in China, Guizhou Moutai is favored by the public investors, and also focused by the local and central governments. However, in the whole investment market, in order to deal with the problem of information asymmetry between enterprises and investors, any rational investor will try to obtain more accurate enterprise information and pay attention to the analysis and suggestions of professionals, so as to ensure the safety of their investment and obtain considerable profits. Therefore, in order to reveal the accurate situation of the enterprise value under the continuous growth of Moutai group’s stock price, provide investors with relevant decision-making basis, and provide useful reference information for the government departments to regulate the liquor market. This paper evaluates the enterprise value of Guizhou Moutai Group by establishing FCFF model and using the historical data collected, and then the actual value of Moutai Group is calculated and a conclusion is drawn. The research shows that: the growth of Moutai Group’s stock price is in line with the development trend of the enterprise and the industry, and the enterprise value has a reasonable support, which is not unreasonably high. At the same time, the analysis shows that the growth ability, profitability and development ability of Moutai Group are relatively strong, and the enterprise has a strong development potential in the future.
Grey GM (1,1) model based on combinatorial buffer operator
Authors: Peng-xiang He , Sheng-xiang Sun
Published: September 2021

Considering that some emerging industries have not developed for a long time, the amount of data available for forecasting future economic problems is relatively limited, complex and changeable. Based on the principle of combinatorial prediction, a combinatorial buffer operator based on different order buffer operators is proposed, and the correlation area between the generated sequence and the original sequence after the buffer operator is used as weighting criterion. The grey GM (1,1) prediction model based on the combined buffer operator was established, which effectively overcame the influence of abnormal data and restored the change rule of data series. The average prediction error of the data in literature [7] by using the combined buffer operator established in this paper was 0.98%. Compared with 6.89%, 11i.59% and 1.30% of the original method, the predction accuracy is significantly improved.
A Government Subsidy Model for Expressway Public Private Partnerships Projects Based on Project Revenue Features and Whole Life-cycle Management
Authors: Li Yihua , Chu Chunchao , Weng Yanzhen , Song Jia
Published: September 2021

Popularisation and application of Public Private Partnerships (PPP) model is an important measure used to deepen the investment and financing reform of China. The transportation industry actively explores and promotes the wide application of PPP models as they have injected new impetus into the construction and development of transportation investment. For PPP projects of expressways that are subsidised by government in the construction or operation period, since the traffic flow in the project construction period or the early operation period is low, the government subsidy is more concentrated and the payments are high, which aggravates pressure on the fiscal purse in the current period and is not conducive to the realisation of smooth fiscal expenditure in the project cooperation period. In this regard, aiming at the features of the investment revenue of expressway projects, a whole life-cycle government optimisation of subsidy mode is proposed through the analysis of the problems existing in the general subsidy mode of the PPP model in the present work. The results show that the proposed model can not only smooth government expenditure in the project’s cooperation period, but also fully exploit the advantages of higher income in the middle and later stages of project operation and maximise the growth potential of government revenue. The results of the research can provide decision-making reference for the development of innovative PPP models for transportation infrastructure in the new Era.