bluuebunny/crossref_metadata_2025 huggingface dataset:
Concepções de Estado que atravessam movimentos sociais: análises provocativas
Authors: Capelini Thalita Calmon , Tavares Gilead Marchezi
Published: July 2018

Partindo da problematização de um cenário de contestação política, o qual se espraiou pelo mundo ao final do ano de 2010, objetivamos analisar as concepções de Estado que perpassam movimentos sociais de luta por direitos. Para tanto, realizamos uma pesquisa-intervenção junto ao Centro de Defesa dos Direitos Humanos de Serra/ES. Durante um ano, participamos das suas Assembleias Gerais, registrando os acontecimentos, as trocas e nossas impressões em diários de campo. Realizamos, ainda, entrevistas com quatro militantes capixabas. As análises foram guiadas tanto pelos registros de diário de campo, quanto pelo material das entrevistas, que foram gravadas e transcritas. Durante o percurso da pesquisa-intervenção, destacamos aquilo que no terreno dos movimentos sociais encontrava-se endurecido: as concepções de Estado totalizador e transcendente, e de poder como sendo de propriedade e localizado no aparelho de Estado. Para compor nossas análises, trazemos as contribuições de Michel Foucault a respeito dos conceitos de governo e governamentalidade.
Trabalhadores Descartáveis? Condição de Terceirizado e Mal-Estar no Trabalho
Authors: Torres Camila Costa , Ferreira Mário César , Ferreira Rodrigo Rezende
Published: July 2018

Investigar os impactos sobre os trabalhadores do processo de terceirização, que se opera no mundo corporativo, tem sido um desafio importante para as ciências do trabalho e da saúde, especialmente para as organizações. Nesse sentido, objetivou-se nesta pesquisa investigar as fontes de mal-estar no trabalho entre terceirizados em uma Instituição de Ensino Superior brasileira. Considerou-se válidas as respostas de 189 trabalhadores à uma questão aberta do Inventário de Avaliação de Qualidade de Vida no Trabalho (IA_QVT), aplicado por meio de um survey virtual. Utilizou-se o aplicativo IRaMuTeQ, de análise de conteúdo, para o tratamento dos dados e identificou-se os núcleos temáticos estruturadores do discurso dos participantes. Nos resultados, as principais fontes de mal-estar percebidas pelos respondentes foram: (a) tratamento desrespeitoso por parte das outras pessoas e baixo salário; (b) distância casa-trabalho e duração da jornada; e (c) condições de trabalho precárias. A situação é crítica para os terceirizados, que revelam dificuldade de mobilização do coletivo para modificar a realidade. Os achados da pesquisa apontam para a necessidade de intervenção nas causas organizacionais geradoras do mal-estar no trabalho, por meio da formulação de política e de programa de QVT. Eles também fornecem pistas para novos estudos.
Grupo de apoio para pais de crianças com implante coclear
Authors: Rezende Fernanda Pádua , Morettin Marina , Yamada Midori Otake
Published: July 2018

O objetivo deste artigo foi apresentar um levantamento bibliográfico sobre grupos de apoio para pais de crianças com implante coclear e discutir os resultados encontrados, buscando evidenciar a importância e os benefícios da utilização dessa ferramenta de auxílio aos pais e cuidadores. Entre os meses de setembro de 2013 e março de 2014 foi realizada a busca de estudos sobre "Grupo de Apoio para pais de crianças com deficiência auditiva, usuárias de implante coclear" nas bases de dados eletrônicas Pubmed, Scielo e Lilacs, utilizando a combinação de descritores selecionados previamente. Após este levantamento, 15 estudos foram selecionados para análise e discussão. Verificou-se a escassez da literatura sobre o tema. No entanto, foi possível constatar que a realização de grupos de apoio com a família de crianças ou pacientes com determinadas deficiências, ou outras condições de saúde, é uma ferramenta de extrema importância, pois permite aos pais enfrentarem as situações complexas com mais segurança, promovendo trocas de experiências, reflexão, alívio do estresse, além de amenizar a ansiedade entre os familiares. Portanto, os estudos analisados indicam a necessidade de algum tipo de suporte aos pais no enfrentamento da deficiência auditiva de seus filhos, de outras deficiências ou condições de saúde, sendo uma ferramenta de suporte emocional fundamental.
Desenvolvimento das relações entre humildade e gratidão na infância
Authors: Siqueira Felipe Queiroz , Freitas Lia Beatriz de Lucca
Published: July 2018

Neste estudo, investigou-se se existe desenvolvimento das relações entre gratidão e humildade na infância. Participaram 28 crianças, distribuídas em três grupos etários (6, 9 e 12 anos), pareadas por sexo. Como instrumento, utilizaram-se duas histórias: em uma delas, o benfeitor foi humilde; na outra, o benfeitor não foi humilde. Cada história foi seguida de uma entrevista semiestruturada. O sentimento de obrigatoriedade de retribuir um favor apresentou variações dependendo do tipo de benfeitor (humilde ou não-humilde). Houve uma maior tendência das crianças mais velhas levarem em conta a humildade e a ausência de humildade do benfeitor, em suas justificativas, quando comparadas com as crianças mais novas. Ao explicitar-se a diferença entre as histórias, a frequência de justificativas que mencionaram a falta de humildade do benfeitor aumentou em todas as idades e surgiu o tema da generosidade. Os resultados sugeriram que há desenvolvimento das relações entre gratidão e humildade na infância. Os dados encontrados contribuem para uma reflexão sobre a elaboração de programas educacionais para crianças, especialmente aqueles relacionados a virtudes.
Psicoterapia de casal em um serviço-escola de Psicologia: uma ilustração clínica
Authors: Osti Natalia Monti Di , Sei Maíra Bonafé , Zanetti Sandra Aparecida Serra
Published: July 2018

Diversas são as estratégias de intervenção no campo da Psicologia Clínica e a psicoterapia de casal se apresenta como uma destas possibilidades. Entende-se que a psicoterapia psicanalítica de casal almeja auxiliar o casal a tornar conscientes conteúdos antes inconscientes, para que possam ser analisados e elaborados. Neste contexto, é importante a análise de mecanismos transferenciais, contratransferenciais, de resistência, além do fenômeno da transmissão psíquica geracional e os pactos inconscientes. Diante deste panorama, objetiva-se desenvolver um estudo teórico-clínico sobre a psicoterapia psicanalítica de casal, por meio da análise de um caso atendido em um serviço-escola de Psicologia. Dentre os resultados, por meio da compreensão da contratransferência, pôde-se perceber que a resistência do casal em debruçar-se em questões de caráter conjugal ligava-se ao fato de intuitivamente apreender que o pacto inconsciente que os mantinha juntos poderia se desfazer caso fosse desvendado e elaborado em terapia. Diante deste contexto, o artigo discute o trabalho que foi possível ser feito no processo terapêutico.
Educação medicalizada: Estudo sobre o diagnóstico de TDAH em um dispositivo de saúde
Authors: Vizotto Luana Paula , Ferrazza Daniele De Andrade
Published: July 2018

O presente trabalho teve como objetivo pesquisar, a partir da análise de prontuários de crianças e adolescentes de um serviço de saúde mental, as principais características daquela população com queixas relacionadas às dificuldades de aprendizagem e problemas de comportamento escolar, com especial atenção aos aspectos relacionados à classificação diagnóstica: ao encaminhamento escolar, ao gênero e à faixa etária. A pesquisa foi realizada em um dispositivo de saúde de uma cidade no interior paulista, onde foi selecionada uma amostra aleatória de 121 prontuários de crianças e adolescentes, na faixa etária entre seis e 15 anos de idade, do gênero feminino e masculino. Os dados mostram que a maioria das crianças encaminhadas ao serviço, cerca de 80%, foi diagnosticada com Transtorno de Déficit de Atenção e Hiperatividade (TDAH). A maioria daquela população, 88%, está na faixa etária entre seis e 10 anos de idade e 90% são do sexo masculino. Conclui-se que a determinação dos diagnósticos de TDAH está vinculada a uma medicina higienista que, atualmente, sob os discursos biológicos e neuroquímicos relacionados ao dispositivo da medicalização, pretende solucionar alguns dos conflitos existentes nos espaços educacionais e descarta qualquer compreensão sobre a diversidade e pluralidade da existência humana.
SEMÂNTICA PARA PEJORATIVOS: CONTRA-ARGUMENTOS À INOCÊNCIA SEMÂNTICA
Authors: Lindemann John Lennon
Published: July 2018

Resumo: Os pejorativos tem sido objeto de uma crescente literatura em filosofia. Hom e May (2013) defendem a tese da Inocência Semântica para explicar a força depreciativa dos pejorativos, tese que recebeu ataques de Sennet e Copp (2014). O objetivo deste artigo é apresentar contribuições a esta discussão, defendendo a tese da Inocência Semântica dos ataques recebidos de Sennet e Copp (2014), mas apresentando um novo argumento contra suas pretensões, mostrando que a tese da Inocência Semântica falha em reconhecer o caráter depreciativo de injurias cuja contraparte neutra seja falsa.Palavras-chave: Semântica. Pejorativos. Injúrias.Abstract: The pejorative have been the object of a growing literature in philosophy. Hom and May (2013) defend the Semantic Innocence thesis to explain a depreciative force of the pejoratives, receiving attacks from Sennet and Copp (2014). The purpose of this article is to present contributions to this discussion, defending the Semantic Innocence thesis of the attacks received from Sennet and Copp (2014), but presenting a new argument against its pretensions, showing that the Semantic Innocence thesis fails to recognize the derogatory character of insults whose neutral counterpart is false. Keywords: Semantics. Pejorative. Injuries.
Delivering a home enteral feeding service to the residents of Trafford
Authors: Ford Alison
Published: July 2018

The number of patients receiving Home Enteral Tube Feeding (HETF) has increased over a number of years. Some patients may have a short term nasogastric/nasojejunal tube placed to help them achieve their nutritional requirements in the short term. Other patients may need to be fed via a gastrostomy tube, either fully or in combination with oral diet long-term. It is important that all patients on HETF receive regular and continuous support. In light of this, Trafford NHS Trust has established a multi-professional nutrition support clinic.
Nutritional care in Chronic Obstructive Pulmonary Disease
Authors: Long Rachel , Stracy Catherine , Oliver Marie-Clare
Published: July 2018

The aim of this article is to provide an overview of the importance of good nutritional care in chronic obstructive pulmonary disease (COPD). It will highlight the importance of nutritional screening and discuss the Managing Malnutrition Pathway in COPD published by BAPEN in 2016. The remainder of the article will provide guidance on what nutritional advice should be provided to COPD patients while undertaking pulmonary rehabilitation.
Your frequent questions
Authors: Martland Rebecca
Published: July 2018

The last instalment in our look at the General Data Protection Regulations, that came into force earlier in May, looks at the steps involved in being compliant now and in the future.
PSED: supporting children
Authors: Webb Penny
Published: July 2018

Continuing our exploration of the prime and specific areas of learning, this month we focus on personal, social, emotional development and how we can support these in our settings.
Plants: a useful, renewable resource
Authors: Garner Lynne
Published: July 2018

This is the third in a new four-part series that will explore the sometimes mysterious but always wonderful world of plants, opening up a once hidden world of knowledge.
THE EFFICIENCY OF BIOLOGICAL THERAPY AND THE FEATURES OF HUMORAL IMMUNITY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Mesnyankina A. A. , Solovyev S. K. , Aseeva E. A. , Nasonov E. L.
Published: July 2018

Objective: to investigate the effect of various biological agents (BAs), including combined treatment with rituximab (RTM) and belimumab (BLM), on the activity of systemic lupus erythematosus (SLE) and to evaluate their efficacy and impact on some parameters of humoral immunity.

Subjects and methods. BAs were prescribed to 54 patients with a reliable diagnosis of SLE with high and medium activity according to SLEDAI-2K; 40 of them received RTM, 7 – BLM; 7 – combined therapy with RTM and BLM. Clinical and laboratory examinations were made in all the patients at the time of their inclusion and then every 3 months during a year. The results were assessed using SLEDAI-2K, BILAG index, Lupus Erythematosus National Assessment (SELENA)-SLEDAI Flare index (SFI) (a moderate, severe exacerbation), and SLE Responder Index (SRI).

Results and discussion. At 3, 6, and 12 months after start of therapy, the use of BAs in all the patients resulted in a disease activity reduction. It was statistically significant (p < 0.00001) in the RTM group; and no statistical analysis was carried out in the BLM and RTM+BLM groups due to the small numbers of patients. At the same time, there was a progressive decrease in the levels of anti-double-stranded DNA (ds-DNA) antibodies (Abs) and an increase in the concentration of the complement fractions C3 and C4 in the RTM and RTM+BLM groups (p < 0.05) at one-year follow-up. After 12 months of therapy with BAs, there was a decrease in IgG (p < 0.02) and IgM (p < 0.03) levels; but overall it remained within the reference ranges. Prior to therapy, irreversible organ damages were recorded in 23 (42.6%) of the 54 patients. The increased damage index at 12 month was observed only in patients receiving RTM, which is probably due to the use of higher-dose glucocorticoids.

Conclusion. All three methods of therapy with BAs in SLE patients demonstrated good efficiency shown as a significant decrease in clinical and laboratory activity measures that were assessed by SLEDAI-2K and the levels of anti-ds-DNA and complement components C3 and C4. The decrease in immunoglobulin levels did not go beyond the reference values. Therapy with BLM and RTM+BLM allowed for managing patients with the low and average doses of oral glucocorticoids, which contributed to the reduction of not only the activity, but also risk of irreversible organ damages.
CERTOLIZUMAB PEGOL IN THE TREATMENT OF TAKAYASU ARTERITIS: THE FIRST EXPERIENCE AND PROSPECTS
Authors: Novikov P. I. , Smitienko I. O. , Sokolova M. V. , Moiseev S. V.
Published: July 2018

Certolizumab pegol (CZP) is the only pegylated biological agent (BA) that does not contain an Fc fragment, which minimizes its transplacental transfer. Takayasu arteritis mostly occurs in reproductive-aged women.

Objective: to evaluate the efficacy and safety of CZP used to treat standard immunosuppressive therapy-resistant Takayasu arteritis.

Subjects and methods. The retrospective study enrolled 6 female patients aged 18 to 35 years with Takayasu arteritis who received CZP. The median disease duration before BA usage was 66 months (24 to 204 months). The median duration of immunosuppressive therapy prior to CZP treatment was 92 months (14 to 132 months). All the female patients had taken glucocorticoids and methotrexate before and during CZP therapy. Only four patients had received two to five immunosuppressive drugs at different times prior to BA administration. Three patients had previously used other BAs. The disease activity was determined by the National Institute of Health (NIH) criteria. The Indian Takayasu Clinical Activity Score (ITAS2010) was used. The disease activity was recorded in all the patients prior to CZP therapy.

Results and discussion. The median duration of CZP treatment was 17 months (6 to 24 months). The median erythrocyte sedimentation rate after CZP usage decreased from 22.5 to 10.5 mm/h; the median C-reactive protein level dropped from 7.8 to 0.39 mg/dl (p<0.05), the median daily dose of prednisolone was reduced from 20 to 8.75 mg (p<0.05). All the patients achieved complete remission an average of 4 months after starting CZP therapy. Three patients were still in remission after 12–24 months. One relapse of the disease was recorded following 24 months. ITAS2010 reduced from 1–4 to 0 in five patients and to 2 in one patient with recurrence. There was a good tolerance in five female patients. The adverse events were herpes labialis in two cases, community-acquired pneumonia in one case, and postoperative abscess in one case too.

Conclusion. CZP in Takayasu arteritis was shown to be an effective drug for remission induction and maintenance. The presented results of the first experience in treating this disease with CZP are indicative of its promising further investigation as a steroid-sparing drug in patients with refractory vasculitis. One of the important advantages of CZP is its supposed high safety throughout pregnancy.
Are Basic Capital Versus Basic Income Debates Too Narrow?
Authors: Prabhakar Rajiv
Published: July 2018

Basic income and basic capital are two common ideas for redesigning distribution. Basic income provides people with a regular income from government. Basic capital provides people with a lump-sum grant. An important part of scholarly debate concentrates on the merits of basic income versus basic capital. This paper claims that these debates are too narrow. First, current debates overlook the way that a chief inspiration for both ideas, Thomas Paine, wanted basic capital and basic income to be complements not substitutes. Second, it is more instructive to compare basic capital or basic income with a wider set of alternatives than with each other. Widening the debates would benefit the discussion of a basic capital or basic income.
A Posteriori Stopping Criteria for Optimized Schwarz Domain Decomposition Algorithms in Mixed Formulations
Authors: Ali Hassan Sarah , Japhet Caroline , Kern Michel , Vohralík Martin
Published: July 2018

This paper develops a posteriori estimates for domain decomposition methods with optimized Robin transmission conditions on the interface between subdomains. We choose to demonstrate the methodology for mixed formulations, with a lowest-order Raviart–Thomas–Nédélec discretization, often used for heterogeneous and anisotropic porous media diffusion problems. Our estimators allow to distinguish the spatial discretization and the domain decomposition error components. We propose an adaptive domain decomposition algorithm wherein the iterations are stopped when the domain decomposition error does not affect significantly the overall error. Two main goals are thus achieved. First, a guaranteed bound on the overall error is obtained at each step of the domain decomposition algorithm. Second, important savings in terms of the number of domain decomposition iterations can be realized. Numerical experiments illustrate the efficiency of our estimates and the performance of the adaptive stopping criteria.
Exotic crossed products and the Baum–Connes conjecture
Authors: Buss Alcides , Echterhoff Siegfried , Willett Rufus
Published: July 2018

We study general properties of exotic crossed-product functors and characterise those which extend to functors on equivariant

C
*

C^{*}

-algebra categories based on correspondences.
We show that every such functor allows the construction of a descent in K
K-theory and we use
this to show that all crossed products by correspondence functors of K-amenable groups are K
K-equivalent.
We also show that for second countable groups the minimal exact Morita compatible crossed-product functor
used in the new formulation of the Baum–Connes conjecture by Baum, Guentner and Willett ([‘Expanders, exact crossed products, and the Baum–Connes conjecture’,
preprint 2013])
extends to correspondences when restricted to separable G-

C
*

C^{*}

-algebras.
It therefore allows a descent in K
K-theory for separable systems.
Your body is our black box: Narrating nations in second-person fiction by Edna O’Brien and Jennifer Egan
Authors: Newman Daniel Aureliano
Published: July 2018

For a century, the disorienting effects of second-person narration have seemed peculiarly well suited to representing the experiential confusions and political contradictions of inhabiting a female body in times of national crisis. This essay examines such effects in Edna O’Brien’s A pagan place and Jennifer Egan’s “Black box,” very different narratives that similarly exploit the deictic and ontological uncertainties of second-person address. Second person in O’Brien’s novel participates in its depiction of a sexually naïve rural Irish girl confronting the conflicting pressures of enforced chastity and reproductive futurism in the name of the Irish State. Emphasis is placed on the narrative’s unusual use of past-tense second-person narration and its intriguing overlap with O’Brien’s nonfictional writings. In Egan’s story, the protean and multivocal second person suggests a sinister fusion of individual and governmental agency, effected through the protagonist’s cybernetically-enhanced body. The result is a deceptively simple critique of post-9/11 American foreign policy as an extension of paternalism and patriarchy in the domestic sphere. The patterns investigated in this paper shed light on other recent uses of the second person in other experimental narratives concerned with identity, self-formation among disenfranchised individuals, and resistance to political and cultural oppression.
Nonlinearity and focalisation in Attila Janisch’sMásnap
Authors: Csönge Tamás
Published: July 2018

The essay’s aim is to examine the relationship between perspective and nonlinear temporal structure in Attila Janisch’s 2004 film,Másnap, which is loosely based on Alain Robbe-Grillet’sLe Voyeur(1955). My analysis revolves around the understanding of two important narratological distinctions, that between a nonlinear presentation of events and a paradoxical plot, and that between narrative focalizalization and textual focalization. According to David Bordwell, the most widespread definition of linearity is when the successive events of A, B and C are presented in the narrative in their chronological order. Any other form of their presentation results in a nonlinear narrative. ButMásnapis a special type of narrative, which highlights the limitation of such traditional dichotomies, because a consistent order of events cannot be reconstructed. Many critics tried to grasp the core of the film’s narrative by trying to put together the original timeline of events, relying on false indicators of logic and coherence, while they failed to recognize the narrative’s real rhetorical purpose in preventing a consistent and unambiguous plot to be established. The narrative’s complexity lies in the fact that both assumptions – that it depicts asubjective experience of timeanda storyworld with strange temporality– are necessary to explain the film’s unusual, fragmented structure and interpret its events. I point out how the film requires us to reinterpret the meanings attached to the familiar techniques of continuity editing and how it converts the practices of the early Nouveau Roman, which marginalizes traditional plot-structures, the notion of character, and conventional descriptions of objects, to interact with a subjective vision governed by a fictional mind.
Die Regulation der hippokampalen Informationsenkodierung durch metabotrope Glutamatrezeptoren
Authors: Manahan-Vaughan Denise
Published: July 2018

Der Hippokampus unterstützt den Erwerb von sowohl räumlichen Repräsentationen als auch von langfristigem räumlichen Gedächtnis. Dies wird ermöglicht durch das Zusammenwirken dreier physiologischer Prozesse, nämlich der Organisation und dem Transfer von Informationen mittels neuronaler Oszillationen, der Erstellung von kontextabhängigen räumlichen Karten mittels Ortszellen und der langfristigen Speicherung räumlicher Lernerfahrung mittels synaptischer Plastizität. Alle drei Prozesse werden durch das glutamaterge System ermöglicht. Die Bindung von Glutamat an ionotrope Glutamatrezeptoren ermöglicht sowohl die schnelle exzitatorische synaptische Transmission (über AMPA-Rezeptoren) als auch die Initiierung einer synaptischen Langzeitspeicherung (über NMDA-Rezeptoren). Aber Glutamat bindet sich auch an metabotrope Glutamat-Rezeptoren (mGlu). Diese Rezeptoren tragen nicht nur zur Stabilität der hippokampalen Enkodierung und der Langlebigkeit der synaptischen Plastizität bei, sie können auch die synaptische Informationsspeicherung unabhängig von der Aktivierung des NMDA-Rezeptors unterstützen und sind für Erwerb und Erhalt des Langzeitgedächtnisses wichtig.
On the relation between the true and sample correlations under Bayesian modelling of gene expression datasets
Authors: Jacobovic Royi
Published: July 2018

The prediction of cancer prognosis and metastatic potential immediately after the initial diagnoses is a major challenge in current clinical research. The relevance of such a signature is clear, as it will free many patients from the agony and toxic side-effects associated with the adjuvant chemotherapy automatically and sometimes carelessly subscribed to them. Motivated by this issue, several previous works presented a Bayesian model which led to the following conclusion: thousands of samples are needed to generate a robust gene list for predicting outcome. This conclusion is based on existence of some statistical assumptions including asymptotic independence of sample correlations. The current work makes two main contributions: (1) It shows that while the assumptions of the Bayesian model discussed by previous papers seem to be non-restrictive, they are quite strong. To demonstrate this point, it is shown that some standard sparse and Gaussian models are not included in the set of models which are mathematically consistent with these assumptions. (2) It is shown that the empirical Bayes methodology which was applied in order to test the relevant assumptions does not detect severe violations and consequently an overestimation of the required sample size might be incurred. Finally, we suggest that under some regularity conditions it is possible that the current theoretical results can be used for development of a new method to test the asymptotic independence assumption.
A Hippo Pathway-Related GCK Controls Both Sexual and Vegetative Developmental Processes in the Fungus Sordaria macrospora
Authors: Radchenko Daria , Teichert Ines , Pöggeler Stefanie , Kück Ulrich
Published: July 2018

The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is conserved from yeast to human, and regulates a variety of key biological processes. In animals, this complex consists of the scaffold protein striatin, the protein phosphatase 2A, and kinases, such as germinal center kinase (GCK) III and GCKIV family members, as well as other associated proteins. The STRIPAK complex was identified as a negative regulator of the Hippo pathway, a large eukaryotic signaling network with a core composed of a GCK and a nuclear Dbf2-related kinase. The signaling architecture of the Hippo core resembles the fungal septation initiation network (SIN) that regulates cytokinesis in fission yeast as well as septation in filamentous fungi. In the filamentous model fungus Sordaria macrospora, core components of the STRIPAK complex have been functionally described and the striatin homolog PRO11 has been shown to interact with the GCK SmKIN3. However, the exact role of SmKIN3 in fungal development has not yet been fully elucidated. Here, we provide comprehensive genetic and functional analysis of SmKIN3 from S. macrospora. Using deletion mutants and site-directed mutagenesis, along with phenotypic and phylogenetic analysis, we provide compelling evidence that SmKIN3 is involved in fruiting body formation, hyphal fusion, and septation. Strains carrying the ATP-binding mutant SmKIN3K39R, as well as a double-deletion strain lacking SmKIN3 and the core STRIPAK subunit PRO11, also revealed severe developmental defects. Collectively, this study suggests that SmKIN3 links both the SIN and STRIPAK complex, thereby regulating multiple key cellular processes.
La integración de la extensión, la docencia y la investigación universitarias: el caso del Proyecto Team-UNA de la Sede Regional Brunca
Authors: Barrantes Elizondo Lena , Valverde Marín Evelyn , Quesada Estrada Emanuel
Published: July 2018

Recibido 04/12/2017   Aceptado 27/03/2018En la búsqueda de la calidad en la relación extensión-docencia-investigación se evidencia la necesidad de estar en constante replanteamiento de estrategias de integración. El Proyecto Team-UNA de la Sede Regional Brunca nació en el año 2010 con el propósito de trabajar con el sector estudiantil del Ciclo Diversificado de la Educación General Básica, para el mejoramiento de su calidad de vida a través de la oferta de tutorías en Inglés gratuitas, logrando así vincular la docencia y la extensión. Este proyecto busca gestionar la participación de estudiantes de la carrera Bachillerato en la Enseñanza del Inglés como tutores y tutoras de estudiantes de secundaria procedentes de colegios públicos de la región. Este estudio tiene como objetivo dar a conocer la experiencia generada, como base para fortalecer el proceso de enseñanza y aprendizaje vivencial. La sistematización se llevó a cabo a través de la recolección de experiencias de los actores principales por medio de su participación en grupos focales a lo largo del desarrollo del proyecto. Como resultado, se llega a la conclusión de que Team-UNA es un catalizador de aprendizaje vivencial que fomenta el análisis crítico, la toma de decisiones y la resolución de problemas, elementos necesarios que respaldan la integración de la docencia, la extensión y la investigación educativas.
Adults’ Perceptions of Nicotine Harm to Children
Authors: Kemp Catherine B. , Spears Claire Adams , Pechacek Terry F. , Eriksen Michael P.
Published: July 2018

BACKGROUND:

Given the changing landscape of tobacco products in recent years, the array of products through which children could be exposed to nicotine has grown substantially. Thus, it is particularly important to understand adults’ perceptions of the harms of nicotine to children and to identify any sociodemographic factors related to inaccurate risk perceptions.

METHODS:

Data were drawn from 2015 to 2016 US nationally representative surveys (n = 11 959). Using multinomial logistic regression analyses, we examined whether race, sex, education, tobacco product use, and having a minor child in the home are associated with the level of perceived harmfulness of nicotine to children.

RESULTS:

Although the majority of respondents characterized nicotine as “definitely harmful” to children, there were notable subgroup differences. Compared with women, men had significantly lower odds of characterizing nicotine as “definitely harmful” to children. Tobacco product users had significantly lower odds of endorsing “definitely harmful” or “don’t know” than nonusers. African American non-Hispanic individuals, Hispanic individuals, and “other” non-Hispanic individuals had significantly lower odds of endorsing “definitely harmful” or “maybe harmful” than white individuals.

CONCLUSIONS:

Although most adults perceive nicotine exposure as harmful for children, there are important differences based on sex, racial and/or ethnic background, and tobacco use status. The results reveal the need for public health efforts to better understand and target inaccurate risk perceptions among specific subgroups.
El concepto de subjetividad estética en el planteamiento de Karl Heinz Bohrer
Authors: Galfione María Verónica
Published: July 2018

Se analiza la reconstrucción del pensamiento romántico de Karl Heinz Bohrer y de su concepción estética de la subjetividad. Se expone el modo en que esta aparece en la reflexión estética de Friedrich Schlegel y se revisan las críticas de Bohrer a la tendencia de Schlegel a reinstaurar una imagen mítica de las relaciones subjetivas. Se examina la forma en que la segunda generación romántica supera este peligro y, por último, se indaga hasta qué punto la concepción de la subjetividad estética que propone Bohrer resulta adecuada para comprender la producción artística contemporánea, así como algunos de los límites que presenta su lectura del pensamiento de Schlegel.
El Nietzsche de Rafael Gutiérrez-Girardot
Authors: Sánchez Lopera Alejandro
Published: July 2018

Se analizan los textos de Rafael Gutiérrez-Girardot sobre F. Nietzsche en torno a la tragedia y el pesimismo. Esta aproximación se elabora a partir de tres temas: estilo, nihilismo y estética. Se argumenta que la interpretación de Gutiérrez-Girardot sobreNietzsche impide que este sea visto solo como un crítico literario. Asimismo, este trabajo brinda el tono a la escritura de Rafael Gutiérrez Girardot y, de este modo, configura su estilo personal.
Bienestar prudencial en la ética de Epicuro
Authors: Carrasco Meza Carlos Gustavo
Published: July 2018

Se expone cr.ticamente una interpretación reciente del hedonismo epic.reo, según la cual este podr.a comprenderse como hedonismo actitudinal. Esta lectura conlleva ciertas tensiones internas y descuida el sentido fundamental del epicure.smo, esto es, que se trata de una teor.a del bienestar prudencial. Al examinar solo este aspecto, se omiten ciertos problemas secundarios, como la legitimidad de interpretar de manera actitudinal una doctrina asentada en el atomismo.
En torno a la técnica y la vida. Conceptos fundamentales de Georges Canguilhem y Xavier Zubiri
Authors: Espinoza Lolas Ricardo , Moya Diez Iván , Vilches Vilches Daniel
Published: July 2018

Se indaga el problema de la explotación técnica del mundo a partir de los pensamientos de Xavier Zubiri y Georges Canguilhem. Se examina el análisis zubiriano de la inteligencia humana y la tesis de Canguilhem sobre la originalidad de la actividad técnica, su relación con la ciencia y su papel en la normatividad del organismo. En ambos autores, el término Umwelt, traducido como “circun-mundo” o medio de comportamiento propio, sirve como base para establecer las posibilidades que tiene la técnica en el desarrollo de nuevas formas de relación con el medio ambiente.
El “realismo científico” a la luz de Xavier Zubiri
Authors: Vargas Abarzúa Esteban
Published: July 2018

Se propone una aproximación al realismo científico desde la perspectiva de Zubiri, para quien, por un lado, la realidad es el modo “de suyo” en que se actualizan los contenidos “en” la aprehensión y, por otro lado, la verdad es la misma realidad en cuanto que “actualizada”. Como la realidad ya se da en la aprehensión, no es un logro de la ciencia, mientras lo postulado solo puede ser erróneo en un proceso de verificaciónEn la medida en que el error es posible por la verdad, los fracasos de la ciencia, en lugarde ser una prueba a favor del antirrealismo, son un indicio que apoya al realismo.
Relación entre gobierno corporativo, control familiar y desempeño en empresas colombianas
Authors: Lagos Cortés Diógenes , Betancourt Ramírez Jose , Gómez Betancourt Gonzalo
Published: July 2018

El gobierno corporativo como herramienta para minimizar los problemas de agencia parece tener un efecto positivo en el desempeño. Este trabajo analiza la relación entre gobierno corporativo, control familiar y desempeño financiero en empresas colombianas. A través del método generalizado de momentos (GMM), se estimó dicha relación en un panel de datos balanceado para 104 empresas inscritas en el Registro Nacional de Valores y Emisores (RNVE) durante el periodo 2008-2014. Las empresas fueron clasificadas como empresa familiar (EF), cuando se identificó una familia como accionista controlante mayoritario. El desempeño fue aproximado a partir de la rentabilidad del activo (ROA) y la rentabilidad del patrimonio (ROE). Para medir el nivel de gobierno corporativo se usaron las 41 prácticas recomendadas en el Código País. Se encontró que solo las prácticas alusivas a la junta directiva se relacionan con el roa, mientras que en el caso del roe no se encontró evidencia de relación con alguna de las prácticas de gobierno corporativo. Respecto al carácter familiar, se encontró que, cuando una familia es el primer accionista controlante, las empresas presentan mayor desempeño. No obstante, cuando los dos primeros accionistas controlantes son familias, se observó que no existe relación con el desempeño
NUMERICAL SOLUTION OF MATHISSON-PAPAPETROU-DIXON EQUATIONS FOR SPINNING TEST PARTICLES IN A KERR METRIC
Authors: Velandia Nelson , Tejeiro Juan M.
Published: July 2018

En este trabajo nosotros calculamos algunas estimaciones del efecto reloj gravitomagnético, tomando en consideración no sólo el campo rotacional de la masa central, sino también el espín de la partícula de prueba, obteniendo valores de Δt = t+ - t- = 2.5212079035x10-8 s. Nosotros usamos la formulación de las ecuaciones de Mathisson-Papapetrou-Dixon para este problema en una métrica de Kerr. Para comparar nuestros resultados numéricos con trabajos previos, nosotros consideramos inicialmente solo el plano ecuatorial y aplicamos también la condición suplementaria de espín de Mathisson-Pirani para la partícula de prueba con espín.
Brote urbano de leishmaniasis en Colombia
Authors: Manotas-Berdugo Hernán , Toro Maldonado Jessica Fernanda , Rodríguez-Rodríguez Jairo , Salgado-García Doris
Published: July 2018

Objetivos Describir las características epidemiológicas, clínicas y el tratamiento de niños con leishmaniasis visceral en Neiva, Huila.Metodología Se realizó un estudio descriptivo del brote de leshmaniasis visceral en niños de la zona urbana de Neiva, Huila, entre los meses de abril a junio de 2012.Resultados Se presentaron siete casos, en niños menores de cinco años, con fiebre prolongada, hepato-esplenomegalia, anemia severa y leucopenia. Cinco ingresaron con trombocitopenia severa, sin manifestaciones hemorrágicas. Seis pacientes recibieron manejo de primera línea con miltefosine, cinco presentaron fracaso terapéutico y se escalonó tratamiento a anfotericina B, de los cuales dos recibieron anfotericina liposomal y tres anfotericina deoxicolato. El principal vector identificado fue la Lutzomyia gomezi y los reservoirios indentifiacados fueron caninos.Conclusión Se describe el primer brote de leishmaniasis visceral en zona urbana, en población pediátrica sin casos de mortalidad. La mayoría de los casos con buena respuesta a Anfotericina B.
Factores asociados a la susceptibilidad al consumo de cigarrillo en escolares de 10 y 11 años en Cartagena, Colombia
Authors: Cogollo Zuleima , De la Hoz Fernando Pio
Published: July 2018

Objetivo Determinar los factores asociados a la susceptibilidad al consumo de cigarrillo en escolares de 10 y 11 años  de sexto grado de la ciudad de Cartagena, Colombia.Método Se realizó un estudio analítico observacional transversal, con una muestra no probabilística por conveniencia de 289 escolares de 10 y 11 años de sexto grado de colegios públicos de Cartagena, Colombia. La información se recolectó a través de la ficha demográfica, el inventario de consumo de cigarrillo y actitudes frente al mismo de la Encuesta Mundial Sobre Tabaquismo en jóvenes (Emta_Joven), escala de susceptibilidad a la persuasión hacia el consumo, la escala Apgar familiar, Rosenberg para autoestima y la escala de Zung de ansiedad.Resultados participaron 289 estudiantes, media para la edad 10,9 (DE=0,25); 157 (54,3%) fueron mujeres y 132 (45,7%) fueron hombres. La frecuencia de experimentación con cigarrillo alguna vez en la vida fue 20 (6,9%) y la alta susceptibilidad al consumo de cigarrillo fue 61 (21,1%). Los factores que se asociaron a alta susceptibilidad a la persuasión para consumo de cigarrillo fueron: ser del sexo masculino (OR de 2,81;  IC95%: 1,56-5,08), disfunción familiar (OR: 2,29; IC95%: 1,23-4,24) y haber fumado alguna vez en la vida (OR: 3,41; IC95%: 1,34- 8,67).Conclusiones  la susceptibilidad al consumo de cigarrillo en estudiantes de sexto grado se asoció a ser del género masculino, la disfuncionalidad familiar y haber fumado alguna vez en la vida.
Malaria complicada en el Chocó: hallazgos clínicos y comparación de datos con el sistema de vigilancia
Authors: Murillo Palacios Olga Lucia , Pedroza Carmen , Bolaños Claudia , Del Toro Elvis , Cubillos Joddy , Chaparro Pablo , Mosquera Miladys
Published: July 2018

Objetivos Describir las características epidemiológicas y clínicas de casos de malaria complicada y establecer la concordancia de esta información con el sistema de vigilancia.Metodología La información se obtuvo de historias clínicas de casos informados en 2011 en el sistema de vigilancia atendidos en el Hospital San Francisco. Se seleccionó una muestra de 62 historias clínicas de 113 casos. Para definir que la historia clínica correspondía a malaria complicada se tuvo en cuenta la presencia de gota gruesa positiva con uno o más criterios de complicación, según la guía clínica nacional y la ficha del sistema de vigilancia. La significancia estadística se determinó con el Chi2 y el estadístico Kappa.Resultados El 37% de los casos presentó una complicación, el 63% presentaron dos o más complicaciones. Las principales complicaciones fueron trombocitopenia y anemia severa, seguido de complicación hepática, hiperparasitemia,  insuficiencia renal y malaria cerebral. En tres de los 54 casos, se usó el Artesunato intravenoso. Se utilizó Quinina en el 59,2% de los casos. La comparación de variables demográficas y especie parasitaria entre las fuentes utilizadas no muestra diferencias significativas, pero el acuerdo general de tipo de complicación fue casi nulo. Las principales complicaciones reportadas no aparecen en la ficha de notificación.Discusión Es necesario continuar otros estudios con el fin de contribuir en la caracterización clínica de la malaria en el Departamento y las intervenciones de manejo. Se recomiendan ajustes a la ficha para fortalecer el análisis y la toma de decisiones.
The imperative of integrating empirical and theoretical considerations when developing policy responses to Internet-gaming disorder
Authors: Wegmann Elisa , Brand Matthias
Published: July 2018

This commentary proposes an integrative approach of theoretical and empirical considerations when developing policy responses to Internet-gaming disorder and when evaluating their efficacy. It complements the overview by Király et al. (2018) about preventive and treatment programs by referring to a lack of inclusion of internal factors, such as individual aspects and cognitions, and missing empirical evidence. This commentary claims the integration of current research addressing individual predisposing and maintaining factors in order to evaluate existing programs and to enhance the exchange between actors including policy. This integrative approach has the potential to develop successful preventive strategies, which could be implemented realistically and socially responsible.
Image processing for fractal geometry-based discrete fracture network modeling input data: A methodological approach
Authors: Kovács Dorottya , Dabi Gergely , Vásárhelyi Balázs
Published: July 2018

With the intent of making data acquisition for fractal geometry-based discrete fracture network (DFN) modeling time-efficient and automatized, a new method was established. For the automation of data retrieval from the images of the studied surfaces, a series of image-processing operations and MATLAB algorithms have been developed. The method allows the retrieval of more than 1,000 fracture-length data/cm2 of one sample in several minutes. This methodology tends to be a useful tool in studies of fracture network geometries. DFN models of a supposed excavated and/or environmental damage zone, designed with the use of data supplied by the above method, are presented in this work as an example.
Influence of Transmucosal Height on Loss of Prosthetic Abutment Torque After Mechanical Cycling
Authors: da Silva Karla Regina Nogueira , Joly Júlio Cesar , Peruzzo Daiane Cristina , Napimoga Marcelo Henrique , Martinez Elizabeth Ferreira
Published: July 2018

The aim of this study was to measure and record the universal transmucosal abutment height, and then evaluate whether it influenced loosening of the abutment screw by analyzing the torque and detorque values after mechanical cycling. Thirty-six implants, model CM Unitite, with internal conical connections (3.5 × 10 mm) and respective universal prosthetic abutments (n = 36, 3.25 × 6 mm), were divided into three groups (n = 12 each) with respective transmucosal heights of 0.8, 3.5, and 5.5 mm. Insertion torque of 20 Ncm was used in accordance with the manufacturer's specifications. Afterward, the samples were submitted to fatigue tests consisting of 500,000 cycles at a frequency of 2Hz, a dynamic compressive load of 120N, and an angle of 30°. The detorque values were measured with a digital torque meter and tabulated to perform statistical analyses; a level of significance of 5% was adopted. The mean detorque values (SD) obtained were 22.83 (6.30), 22.5 (5.45), and 19.41 (4.69) Ncm for transmucosal abutments with heights of 0.8, 3.5, and 5.5 mm, respectively, and showed no statistically significant difference (P = .262). The authors of this study concluded that the transmucosal height of prosthetic abutments submitted to mechanical fatigue did not influence the detorque values.
Introduction
Authors: Smith Vero Rose
Published: July 2018

An essay setting the stage for this special issue of the IJSW.
Hybrid effect of fibre mesh and short fibres on the biaxial bending behaviour of TRC
Authors: Li Dong , Ding Yining , Wang Qing , Zhang Yongchao , Azevedo Cecilia , Zhang Yulin
Published: July 2018

Textile mesh-reinforced concrete (TRC) and mortar have been studied in recent years. However, current testing methods are focused on simply supported members under uniaxial bending; these are inadequate for analysis of a biaxially tensioned fibre mesh and incapable of revealing the biaxial behaviour of a TRC panel. Moreover, the fibres can be damaged by the alkalinity of concrete. To overcome this inadequacy, a series experiment of two-way panels is carried out. The methodology used here consists of the experiment and analysis of experimental data, including evaluation of the alkali resistance, biaxial bending capacity and toughness of two-way slabs. Suitable fibres are selected based on alkali resistance; the effect of fibre meshes on the biaxial bending capacity of the two-way TRC slabs is studied. By addressing the disadvantages of brittle fibre mesh-reinforced concrete compared with conventional reinforced-concrete panels, a significant improvement in the ductility of a TRC panel with steel fibres is achieved. Following the analysis of the experimental data, it can be concluded that a conventional steel mesh with reinforcement ratio of 0·2% can be replaced by a combination of glass or basalt fibre mesh and steel fibres.
People-centeredness in health system reform. Public perceptions of private and public hospitals in South Africa
Authors: Maseko Lebogang , Harris Bronwyn
Published: July 2018

INTRODUCTION: South Africa's planned National Health Insurance system seeks to transform and integrate public and private healthcare services, as part of wider efforts to realise universal health coverage. Ensuring quality, acceptable care is crucial for public buy-in to these changes. In this study the public perceptions of the country's private and state hospitals are explored. A better understanding may guide improvements in public sector services, and strengthen confidence and trust in health system reforms. METHODS: Eight qualitative focus group discussions were held with 54 participants delineated by race ('black' and 'white' South Africans) and experience (recent or indirect) of public and private hospital services. The views on quality of care, cleanliness, satisfaction, staff attitudes, origins of perceptions, and suggestions for improving state hospitals were explored. FINDINGS/RESULTS: Thematic content analysis revealed an almost-automatic initial perception that private hospitals are "good" and state hospitals "bad". However, on further exploration, a more nuanced understanding surfaced around the costs and affordability of private and public hospitals, and trust in and acceptability of health services. CONCLUSION: Health systems are also human systems, with personal encounters at their heart. In order to acceptably serve people and society, policy emphasis is needed to build a culture of person-centred care in the public sector. Key words: National Health Insurance, people-centeredness, health system reform, universal health coverage, public perceptions