bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Trends in Estimating Risk of Cancer from Exposure to Low Doses of Ionising Radiation
Authors: Majer Marija , Knežević Željka , Saveta Miljanić
Published: September 2014

Although ionising radiation has proven beneficial in the diagnosis and therapy of a number of diseases, one should keep in mind that irradiating healthy tissue may increase the risk of cancer. In order to justify an exposure to radiation, both the benefits and the risks must be evaluated and compared. The deleterious effects of medium and high doses are well known, but it is much less clear what effects arise from low doses (below 0.1 Gy), which is why such risk estimates are extremely important. This review presents the current state, important assumptions and steps being made in deriving cancer risk estimates for low dose exposures.
Plant-Pathogenic Fungi in Seeds of Different Pea Cultivars in Poland
Authors: Wilman Karolina , Stępień Łukasz , Fabiańska Izabela , Kachlicki Piotr
Published: September 2014

Legume crops are exposed to infection by fungal pathogens, which often results in contamination with mycotoxins. The aim of this study was to evaluate the level of field resistance/susceptibility of edible and fodder pea cultivars to the colonization of seeds by fungal pathogens in two subsequent seasons, as well as to identify the pathogens present in the seeds of the tested cultivars. Alternaria spp. were the most common fungi isolated from pea seeds in both seasons, followed by Fusarium spp., Stemphylium spp., Ulocladium spp., Botrytis cinerea Pers., Epicoccum nigrum Link., and Phomapinodella L. K. Jones. The highest percentage of infected seeds (55 %) was recorded for cultivar Ezop. The presence of a large number of fungi was found in 2012 for cultivars Santana, Tarchalska, Medal, Cysterski, Mentor, Lasso, and Ezop. Fodder cultivars displayed a lower infection level than edible cultivars. We can conclude that Alternaria spp. were the most frequent fungi present in pea seeds in Poland and Fusarium spp. were likely the most dangerous, having in mind their established mycotoxigenic abilities.
Inattentional Blindness Increased with Augmented Reality Surgical Navigation
Authors: Dixon Benjamin J. , Daly Michael J. , Chan Harley H.L. , Vescan Allan , Witterick Ian J. , Irish Jonathan C.
Published: September 2014

Background

Augmented reality (AR) surgical navigation systems, designed to increase accuracy and efficiency, have been shown to negatively impact on attention. We wished to assess the effect “head-up” AR displays have on attention, efficiency, and accuracy, while performing a surgical task, compared with the same information being presented on a submonitor (SM).

Methods

Fifty experienced otolaryngology surgeons (n = 42) and senior otolaryngology trainees (n = 8) performed an endoscopic surgical navigation exercise on a predissected cadaveric model. Computed tomography-generated anatomic contours were fused with the endoscopic image to provide an AR view. Subjects were randomized to perform the task with a standard endoscopic monitor with the AR navigation displayed on an SM or with AR as a single display. Accuracy, task completion time, and the recognition of unexpected findings (a foreign body and a critical complication) were recorded.

Results

Recognition of the foreign body was significantly better in the SM group (15/25 [60%]) compared with the AR alone group (8/25 [32%]; p = 0.02). There was no significant difference in task completion time (p = 0.83) or accuracy (p = 0.78) between the two groups.

Conclusion

Providing identical surgical navigation on a SM, rather than on a single head-up display, reduced the level of inattentional blindness as measured by detection of unexpected findings. These gains were achieved without any measurable impact on efficiency or accuracy. AR displays may distract the user and we caution injudicious adoption of this technology for medical procedures.
Correlation between Skin-prick Testing, Individual Specific IgE Tests, and a Multiallergen IgE Assay for Allergy Detection in Patients with Chronic Rhinitis
Authors: Cho Jae Hoon , Suh Jeffrey D. , Kim Jin Kook , Hong Seok-Chan , Park Il-Ho , Lee Heung-Man
Published: September 2014

Background

Allergy test results can differ based on the method used. The most common tests include skin-prick testing (SPT) and in vitro tests to detect allergen-specific IgE. This study was designed to assess allergy test results using SPT, individual specific IgE tests, and a multiallergen IgE assay (multiple allergen simultaneous test) in patients with chronic rhinitis and controls.

Methods

One hundred forty total patients were prospectively enrolled in the study, including 100 patients with chronic rhinitis and 40 control patients without atopy. All eligible patients underwent SPT, serum analysis using individual specific IgE test, and multiple allergen simultaneous test against 10 common allergens. Allergy test results were then compared to identify correlation and interest agreement.

Results

There was an 81–97% agreement between SPT and individual specific IgE test in allergen detection and an 80–98% agreement between SPT and multiple allergen simultaneous test. Individual specific IgE test and multiple allergen simultaneous test allergy detection prevalence was generally similar to SPT in patients with chronic rhinitis. All control patients had negative SPT (0/40), but low positive results were found with both individual specific IgE test (5–12.5%) and multiple allergen simultaneous test (2.5–7.5%) to some allergens, especially cockroach, Dermatophagoides farina, and ragweed. Agreement and correlation between individual specific IgE test and multiple allergen simultaneous test were good to excellent for a majority of tested allergens.

Conclusion

This study shows good agreement and correlation between SPT with individual specific IgE test and multiple allergen simultaneous test on a majority of the tested allergens for patients with chronic rhinitis. Comparing the two in vitro tests, individual specific IgE test agrees with SPT better than multiple allergen simultaneous test.
Sinonasal Solitary Chemosensory Cells “Taste” the Upper Respiratory Environment to Regulate Innate Immunity
Authors: Lee Robert J , Cohen Noam A
Published: September 2014

Background

It is not fully understood how sinonasal epithelial cells detect the presence of pathogens and activate innate defense responses necessary for protecting the upper airway from infection. One mechanism is through bitter taste receptors (T2Rs), which are expressed in the sinonasal cavity. One T2R isoform, T2R38, is expressed in ciliated cells and detects quorum-sensing molecules from gram-negative bacteria, activating antimicrobial nitric oxide production. More recent studies have examined the role of T2Rs expressed in a sinonasal cell type that has only recently been identified in humans, the solitary chemosensory cell (SCC). We sought to provide an overview of SCCs and taste receptor function in human sinonasal defense as well as implications for chronic rhinosinusitis (CRS).

Methods

A literature review of the current knowledge of SCCs and taste receptors in sinonasal physiology and CRS was conducted.

Results

Human sinonasal SCCs express both bitter T2R and sweet T1R2/3 receptors. Activation of SCC T2Rs activates a calcium signal that propagates to the surrounding epithelial cells and causes secretion of antimicrobial peptides. T1R2/3 sweet receptor activation by physiological airway surface liquid (ASL) glucose concentrations attenuates the T2R response, likely as a mechanism to prevent full activation of the T2R pathway except during times of infection, when pathogens may consume ASL glucose and reduce its concentration.

Conclusion

SCCs appear to be important mediators of upper airway innate immunity, as the SCC T2Rs regulate antimicrobial peptide secretion, but further study is needed to determine the specific T2R isoforms involved as well as whether polymorphisms in these isoforms affect susceptibility to infection or patient outcomes in CRS. The inhibitory role of T1R2/3 sweet receptor suggests that T1R2/3 blockers may have therapeutic potential in some CRS patients, particularly those with diabetes mellitus. However, further clinical study of the relationship between infection and T1R2/3 genotype is required.
Differential Expression of Innate Immunity Genes in Chronic Rhinosinusitis
Authors: Detwiller Kara Y. , Smith Timothy L. , Alt Jeremiah A. , Trune Dennis R. , Mace Jess C. , Sautter Nathan B.
Published: September 2014

Background

Prior research has identified several components of the innate immune system that may play a significant role in chronic rhinosinusitis (CRS), but the role of innate immunity in patients with CRS is poorly understood. The objective of this study was to determine differential expression of innate immunity genes in the mucosa of patients with CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP) when compared with controls.

Methods

Control patients (n = 9) and patients with CRS (n = 36) who failed medical management were prospectively enrolled. Ethmoid mucosa samples were harvested during surgery and quantitative real-time polymerase chain reaction was used to determine levels of mRNA expression of Toll-like receptor (TLR) 2 and TLR9 and interleukin-22 receptor (IL-22R). The average change in crossover threshold and fold change were calculated and differences between controls, CRSwNP, and CRSsNP were compared. Statistical analysis was performed using the Kruskall–Wallis and adjusted Mann-Whitney U tests.

Results

Patients with CRSwNP (n = 16) and CRSsNP (n = 20) showed lower mean expression of TLR2 (p < 0.05) compared with controls. Patients with CRSsNP showed significantly higher mean expression of IL-22R (p < 0.05) than controls.

Conclusion

The sinonasal innate immune system may have a significant role in the development of CRS. We found differential expression of innate immune mediators between patients with and without nasal polyposis. These results provide further evidence of disruption of innate immunity at the mucosal level in CRS and highlight differences between polyp- and non-polyp-forming CRS phenotypes at the molecular level. In addition to our knowledge, this is the first report of altered IL-22R expression in CRSsNP patients. This study was a part of the clinical trial NCT01332136 registered in www.clinicaltrials.gov .
Relationship between Sputum Eosinophilia and Sinus Disease in Patients with Eosinophilic Bronchitis
Authors: Neighbour Helen , Goodwin Jodi , Strychowsky Julie , Rahman Sadaf , Abdelshaheed Rami , Nair Parameswaran , Sommer Doron D.
Published: September 2014

Background

Sinus disease is commonly seen in patients with asthma, and several studies have been published describing the relationship between sinus disease and the inflammation seen in the sputum of asthmatic subjects. In this article, we expand on this knowledge by studying patients with eosinophilic bronchitis with and without asthma.

Methods

We describe the relationship between the severity of sinus disease determined by the Lund-Mackay score and sputum eosinophilia. Comparisons with blood eosinophil and total immunoglobulin (IgE) measurements are made.

Results

We have shown that the severity of sinus disease is positively correlated with sputum eosinophil counts, and the site of sinus disease affected the level of eosinophilia. There was a positive correlation between sputum eosinophils and blood eosinophils, but there was no relationship with blood total IgE levels.

Conclusions

We have confirmed that there is a link between upper and lower airway inflammation and that this is not limited to patients with asthma. The process is associated with systemic inflammation as evidenced by increased blood eosinophils but appears to be independent of IgE.
Respiratory Epithelial Adenomatoid Hamartoma of the Nose: An Updated Review
Authors: Nguyen Duc Trung , Gauchotte Guillaume , Arous Fabien , Vignaud Jean-Michel , Jankowski Roger
Published: September 2014

Background

This study was designed to update clinical and imaging features as well as treatment outcomes of the nasal respiratory epithelial adenomatoid hamartoma (REAH). Data sources included case reports, original articles, and reviews published in English or French in PubMed from 1995 to date.

Methods

Only published articles that met Wenig's histological criteria for the diagnosis of REAH were included.

Results

REAH is not rare and is probably underdiagnosed. It is usually observed in the fifth decade of life with a 3:2 male/female predilection. REAH can be represented in two forms: as an isolated lesion (less frequent) or in association with an inflammatory process (especially nasal polyposis). It was observed in 35–48% of patients undergoing endoscopic endonasal surgery for nasal polyposis. Its origin is found, in most cases, in the olfactory cleft, which is exhibited on computed tomography (CT) scans by widened opacified olfactory clefts without bone erosion. Resection of REAH from the olfactory clefts does not worsen, but instead, can improve the sense of smell after surgery.

Conclusion

Looking for REAH on CT scans and during endoscopic examination can lead to its diagnosis and help avoid aggressive surgical procedures and their complications. Endoscopic resection is the treatment of choice. The removal of REAH constitutes a specific surgery on the olfactory clefts, which can improve nasal obstruction as well as sense of smell. Whether REAH can be defined as a hamartoma, an inflammatory reactive process, or a neoplastic lesion remains to be determined.
Nasal Septal Turbinate: Cadaveric Study
Authors: Şişman A. Sezim , Acıoğlu Engin , Yiğit Özgür , Akakın Dilek , Cilingir Özlem Tugçe
Published: September 2014

Background

Despite the importance of its location, the functional behavior of the nasal septal turbinate (NST) is still not completely understood. Basic histological knowledge is still lacking. The aim of this study was to describe the histological features of the NST and to compare its morphometric features to those of the adjacent nasal septum and the inferior and middle turbinates.

Methods

The study included 50 fresh cadavers. Excisional biopsy specimens of the NST with adjacent posterior septum were collected. In addition, mucosal and submucosal biopsy specimens were taken of the inferior and middle turbinates. Morphometric analysis was performed on five different tissue types: glandular elements, connective tissue stroma, arterial structures, and capillary or venous sinusoids.

Results

The mean proportion of venous sinusoids was statistically lower in the nasal septum and NST than in the inferior and middle turbinate. The mean proportion of glandular tissues was higher in the NST than in other regions of the nasal cavity. The mean proportion of arterial tissue was lower in the nasal septum and the NST. Significantly fewer capillary elements were found in the inferior and middle turbinates than in the nasal septum and NST. The mean proportion of connective tissues was lower in the NST than in other regions of the nasal cavity.

Conclusion

The similar histopathological cell distribution in the middle and inferior turbinate supported a function as an erectile organ, but the findings for the NST pointed to different functional properties of this region.
Nasal Mucociliary Clearance in Obstructive Sleep Apnea Syndrome Patients
Authors: Deniz Mahmut , Gultekin Erdogan , Ciftci Zafer , Alp Recep , Ozdemir Damla Nihan , Isik Aklime , Demirel Oral Burak
Published: September 2014

Background

The main objective of this study was to investigate the correlation between the level of mucociliary dysfunction and severity of obstructive sleep apnea syndrome (OSAS). The effect of smoking in OSAS patients on mucociliary dysfunction was also assessed.

Methods

It is a descriptive study that compares variables between groups (univariate analysis). In this clinical trial 122 patients with varying degrees of OSAS and 49 healthy volunteers were included (n = 171). Patients were divided into three groups as having mild, moderate, and severe OSAS, according to their apnea hypopnea index (AHI) values. (AHI values are typically categorized as 5–15/hr, mild OSAS; 15–30/hr, moderate OSAS; and > 30/hr, severe OSAS.) The control group was comprised of healthy subjects. Each group was divided into smoking and nonsmoking subgroups. The mucociliary rates of the subjects were measured using the saccharin test. Statistical analysis was performed with the GraphPad Prism Version 3 pocket program.

Results

Mild and moderate OSAS groups showed similar results with control group (p = 0.869), but severe OSAS patients showed a statistically significant difference with control group (Kruskal–Wallis [KW] = 32.28; p = 0.0032 and p < 0.05). Although in the moderate OSAS group the mucociliary clearance rates showed a tendency to decrease, this decrease was not significant (p = 0.453). A statistically significant difference was observed between smokers and nonsmokers in terms of mucociliary clearance times in all groups (KW = 18.24; p = 0.001).

Conclusion

The nasal mucociliary system is significantly deteriorated in severe OSAS patients and they should be meticulously observed to prevent sinonasal infections. Measures to enhance mucociliary activity in these patients should be taken. Smoking, a well-known inhibitor of mucociliary activity, also has a negative impact on the mucociliary function of OSAS patients and quitting smoking would be of benefit for these patients.
An open randomized controlled trial to compare the efficacy of two fixed dose combinations of artemesinin based combinations for uncomplicated falciparum malaria in Bangladesh
Authors: Samad R , Rahman MR , Yunus EB , Hussain MA , Arif SM , Islam MN , Hafiz SAMMA , Hossain MM , Faiz MA
Published: September 2014

National Malaria Control Program (NMCP) of Bangladesh has introduced Artemisinin Based Combination (ACT), Coartem(R) (Artemether-Lumefantrine (AL), fixed dose combination, in the confirmed cases of uncomplicated P. falciparum malaria since 2004. Despite the reduction of mortality due to malaria, the development and spread of anti-malarial drug resistance wordwide posing a threat to the health services and will make it difficult to control malaria in Bangladesh in future. We need to have an alternative to Coartem which could be Artesunate-amodiaquine (AA) in a fixed dose combination (FDC), a cheaper altenative not yet evidenced to be effective and safe to our population. In this study we compared the efficacy and safety of Artemether + Lumefantrene (FDC, Coartem®) with Artesunate +Amodiaquine tablets (100/270 mg FDC) for the treatment of uncomplicated P. falciparum malaria in three high risk multi-drug resistant malaria prevalent areas of Bangladesh. It was an open label randomized controlled trial conducted between December 2008 and November 2009 in 4 upazillas in patients over the age 12 to 60 years diagnosed as a case of uncomplicated P.falciparum malaria. The outcome of the cases were measured as clinical response, parasitological response, defervescence time and parasite clearance time. Drug safety was assessed by comparing the adverse events. A total of 252 cases were randomized to receive Artesunate + Amodiaquine (AA group, 147 cases) and Artemether + Lumefantrene (AL group, 106 cases), one lost to follow up at day 28 in AA group. The distribution of the cases was comparable by age, sex and study sites. Treatment success response was observed 100% in the AL group and AA group had 99%, two failures with AA were late treatment failures and the difference was not statistically significant (p>.1). The parasitological sensitive (S) response was observed in 97% of cases in AL group and 95% in the AA group, and was not a statistically significant difference. There was no significant difference in deffervescence time and parasite clearance time between two groups of cases. No serious adverse events were observed. The frequencies of minor adverse events were insignificantly different between the two treatment groups. The two ACT regimen, AA and AL had no significant difference in efficacy and safety for treatment of Uncomplicated Malaria in Bangladesh. However, there were few more failures with AA regimen compared to AL regimen, which was not statistically significant. Both these regimens can be used alternatively by the NMCP of Bangladesh as first-line treatment option. DOI: http://dx.doi.org/10.3329/bmrcb.v39i3.20310 Bangladesh Med Res Counc Bull 2013; 39: 109-115
Comparison of modified Friedewalds formula with direct measurement of low-density lipoprotein cholesterol in Bangladeshi population
Authors: Chowdhury N , Saiedullah M , Khan MAH , Rahman MR
Published: September 2014

A modification of Friedewalds formula to estimate serum low-density lipoprotein cholesterol (LDLC) up to serum triglyceride (TG) level of 11.3 mmol/L in Bangladeshi population has recently been published. The aim of this study was to compare the modified formula with direct measurement of LDLC in Bangladeshi population in a different setting. One thousand and fifty two specimens from adult subjects were analyzed. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), LDLC and TG were measured by standard methods. The modified Friedewalds formula was applied to estimate LDL cholesterol concentration. Results were expressed as mean ± SD and calculated LDLC was compared with measured LDLC by two-tailed paired t test, Bland-Altman plot for absolute bias, Pearsons correlation coefficients of calculated LDLC with measured LDLC and Passing & Bablok regression equation of calculated LDLC against measured LDLC. The mean ± SD of measured LDLC was 2.98±0.82 mmol/L. LDLC calculated by modified Friedewalds formula was 2.77±0.86 mmol/L. The mean absolute bias was 0.20±0.32 mmol/L, Pearsons correlation coefficient (r) was 0.9293 (P<0.0001) and Passing & Bablok regression equation was y=  0.3856+1.0597x for modified formula up to serum TG?11.3 mmol/L. Compared to original Friedewalds formula, performance of the modified Friedewalds formula was better up to serum TG?4.52 mmol/L. The study reveals that the modified Friedewalds formula may be used to calculate LDLC approximately in Bangladeshi population. DOI: http://dx.doi.org/10.3329/bmrcb.v39i3.20312 Bangladesh Med Res Counc Bull 2013; 39: 120-123
Microbial contamination in herbal medicines available in Bangladesh
Authors: Noor R , Huda N , Rahman F , Bashar T , Munshi SK
Published: September 2014

Plants have long been used as herbal medicines in many countries. However, microbial contamination of these medicines may affect human health. Present study was performed to assess the pathogenic proliferation in the locally available commercial herbal oral medicines. The pathogenic load was compared with the microbiological standard given by the British Pharmacopoeia. Out of 85 oral liquid samples, 2 were found to be highly contaminated with a total aerobic bacterial load of 1.24×105 cfu/ml, 10 samples were contaminated with fungi (1.2×104-6.3×104 cfu/ml). Tests for specific pathogens were carried out. One sample showed contamination by coliforms but none of the samples were contaminated by Salmonella spp. and Shigella spp. Among 40 semisolid samples, one showed to be contaminated with bacteria (1.93×105 cfu/g) and 5 samples consisted of fungal load ranging between 1.5×104-2.2×104 cfu/g. The presence of bacteria and fungi in these samples thus suggest the fact that aseptic handling is necessary during processing of oral herbal medicines. DOI: http://dx.doi.org/10.3329/bmrcb.v39i3.20313 Bangladesh Med Res Counc Bull 2013; 39: 124-129
Comparison of P2Y12 receptor inhibition by clopidogrel and prasugrel in patients undergoing percutaneous coronary intervention
Authors: Haq MM , Ahsan CH , Amin MN , Karim MR , Ali ML , Khan SR , Chowdhury MZ , Mansur M , Millat MH , Rashid MA
Published: September 2014

Dual antiplatelet treatment (DAPT) with aspirin and clopidogrel is vital after percutaneous coronary intervention (PCI). Clopidogrel and prasugrel act on P2Y12 platelet surface receptors. Both these P2Y12 inhibitors are pro-drugs and depend on cytochrome system of the liver for their conversion to active metabolite. There is growing concern regarding suboptimal response in platelet inhibition by clopidogrel. Verify Now system got approval by Federal Drug Administration, USA, for assessing platelet function as its result is almost comparable to gold standard Light Transmission Aggregometry (LTA). There are no data on the prevalence of clopidogrel resistance in Bangladeshi population. Prasugrel, as an antiplatelet drug, is a newer introduction in this country. This study will show light on the efficacy of these drugs on our population especially in patients who undergo PCI where DAPT is mandatory. A total 120 (60 diabetics ) patients with Acute Coronary Syndrome (ACS), were alternatively given 600 mg clopidogrel loading dose (LD) followed by 75 mg maintenance dose (MD) daily or 60 mg LD of prasugrel followed by 10 mg MD daily. Five samples of blood were taken at different time intervals over a period of 2 weeks. Measurement of percent inhibition of P2Y12 was done by VerifyNow. Patients who showed less than 20% inhibition (clopidogrel resistant) at any stage were switched to prasugrel. The outcomes of clopidogrel, prasugrel and clopidogrel switched to prasugrel groups were then compared. Nearly half (46.7%) of the patients in the clopidogrel group was found resistant to the drug as opposed to none in the prasugrel group. No difference was found between diabetic and non-diabetic subjects with respect to drug resistance. Intracoronary blood samples showed high degree of platelet inhibition with prasugrel. There was a gradual decline of platelet inhibition over two weeks with prasugrel. Almost fifty percent of the population is clopidogrel resistant in our study. Prasugrel is a much more potent antiplatelet drug and should be preferred in patients undergoing PCI. Prasugrel may also show resistance over time. DOI: http://dx.doi.org/10.3329/bmrcb.v39i3.20315 Bangladesh Med Res Counc Bull 2013; 39: 139-145
A Girl with Ulcerative Colitis in a Tertiary Care Hospital- a Case Report
Authors: Nahar N , Sultana S , Chowdhury MLL , Chowdhury K
Published: September 2014

Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of colon. We are presenting a case of ulcerative colitis in a 12 yrs old girl who presented with passage of loose bloody stool, low grade intermittent fever, abdominal pain with tenesmus and arthralgia of large joint along with significant wt loss. Diagnosis was confirmed by colonoscopy and biopsy. Treatment was thereafter started with parenteral steroid initially then oral steroid and meselamine. The patient is now on remission and is on regular follow up. DOI: http://dx.doi.org/10.3329/pulse.v6i1-2.20352 Pulse Vol.6 January-December 2013 p.53-56
DNA Markers for Food Products Authentication
Authors: Scarano Daria , Rao Rosa
Published: September 2014

Media constantly refer of unscrupulous producers that adulterate, alter or replace premium products in food chains with the goal to maximize illegally profits. Food traceability is a central issue for the identification of improper labeling of processed food and feed and there are rules aimed to protect consumers and producers against fraudulent substitution of quality products in food chain, but the tools available are not always appropriate. DNA-based markers proved very effective for fresh and processed food molecular authentication. In this review, we illustrate potential and limits of different DNA markers focusing on low, medium and high-throughput markers, in order to monitor the genetic identity of food components in meat, fish and plants net-chains.
Entropy Evaluation Based on Value Validity
Authors: Kvålseth Tarald
Published: September 2014

Besides its importance in statistical physics and information theory, the Boltzmann-Shannon entropy S has become one of the most widely used and misused summary measures of various attributes (characteristics) in diverse fields of study. It has also been the subject of extensive and perhaps excessive generalizations. This paper introduces the concept and criteria for value validity as a means of determining if an entropy takes on values that reasonably reflect the attribute being measured and that permit different types of comparisons to be made for different probability distributions. While neither S nor its relative entropy equivalent S* meet the value-validity conditions, certain power functions of S and S* do to a considerable extent. No parametric generalization offers any advantage over S in this regard. A measure based on Euclidean distances between probability distributions is introduced as a potential entropy that does comply fully with the value-validity requirements and its statistical inference procedure is discussed.
Assessment of Geogenic Contaminants in Water Co-Produced with Coal Seam Gas Extraction in Queensland, Australia: Implications for Human Health Risk
Authors: Stearman William , Taulis Mauricio , Smith James , Corkeron Maree
Published: September 2014

Organic compounds in Australian coal seam gas produced water (CSG water) are poorly understood despite their environmental contamination potential. In this study, the presence of some organic substances is identified from government-held CSG water-quality data from the Bowen and Surat Basins, Queensland. These records revealed the presence of polycyclic aromatic hydrocarbons (PAHs) in 27% of samples of CSG water from the Walloon Coal Measures at concentrations <1 µg/L, and it is likely these compounds leached from in situ coals. PAHs identified from wells include naphthalene, phenanthrene, chrysene and dibenz[a,h]anthracene. In addition, the likelihood of coal-derived organic compounds leaching to groundwater is assessed by undertaking toxicity leaching experiments using coal rank and water chemistry as variables. These tests suggest higher molecular weight PAHs (including benzo[a]pyrene) leach from higher rank coals, whereas lower molecular weight PAHs leach at greater concentrations from lower rank coal. Some of the identified organic compounds have carcinogenic or health risk potential, but they are unlikely to be acutely toxic at the observed concentrations which are almost negligible (largely due to the hydrophobicity of such compounds). Hence, this study will be useful to practitioners assessing CSG water related environmental and health risk.
Correction of Two Papers: “Functional Cross-Talk between the α1- and β1-Adrenergic Receptors Modulates the Rapidly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes” and “Population Structure of the Greenhouse Whitefly, Trialeurodes vaporariorum (Westwood), an Invasive Species from the Americas, 60 Years after Invading China” in Int. J. Mol. Sci. Volume 15, Issue 8, 2014
Authors: IJMS Editorial Office
Published: September 2014

Two papers [1,2] were recently published with incorrect page range, DOI numbers and publishing date in the PDF full text versions. [...]
Designing with Protocells: Applications of a Novel Technical Platform
Authors: Armstrong Rachel
Published: September 2014

The paper offers a design perspective on protocell applications and presents original research that characterizes the life-like qualities of the Bütschli dynamic droplet system, as a particular “species” of protocell. Specific focus is given to the possibility of protocell species becoming a technical platform for designing and engineering life-like solutions to address design challenges. An alternative framing of the protocell, based on process philosophy, sheds light on its capabilities as a technology that can deal with probability and whose ontology is consistent with complexity, nonlinear dynamics and the flow of energy and matter. However, the proposed technical systems do not yet formally exist as products or mature technologies. Their potential applications are therefore experimentally examined within a design context as architectural “projects”—an established way of considering proposals that have not yet been realized, like an extended hypothesis. Exemplary design-led projects are introduced, such as The Hylozoic Ground and Future Venice, which aim to “discover”, rather than “solve”, challenges to examine a set of possibilities that have not yet been resolved. The value of such exploration in design practice is in opening up a set of potential directions for further assessment before complex challenges are procedurally implemented.
A Review on Adsorption of Fluoride from Aqueous Solution
Authors: Habuda-Stanić Mirna , Ravančić Maja , Flanagan Andrew
Published: September 2014

Fluoride is one of the anionic contaminants which is found in excess in surface or groundwater because of geochemical reactions or anthropogenic activities such as the disposal of industrial wastewaters. Among various methods used for defluoridation of water such as coagulation, precipitation, membrane processes, electrolytic treatment, ion-exchange, the adsorption process is widely used. It offers satisfactory results and seems to be a more attractive method for the removal of fluoride in terms of cost, simplicity of design and operation. Various conventional and non-conventional adsorbents have been assessed for the removal of fluoride from water. In this review, a list of various adsorbents (oxides and hydroxides, biosorbents, geomaterials, carbonaceous materials and industrial products and by-products) and its modifications from literature are surveyed and their adsorption capacities under various conditions are compared. The effect of other impurities on fluoride removal has also been discussed. This survey showed that various adsorbents, especially binary and trimetal oxides and hydroxides, have good potential for the fluoride removal from aquatic environments.
Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance
Authors: Anreddy Nagaraju , Gupta Pranav , Kathawala Rishil , Patel Atish , Wurpel John , Chen Zhe-Sheng
Published: September 2014

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been implicated in several types of cancers. In recent years, tyrosine kinase inhibitors (TKIs) have been developed to interfere with the activity of deregulated kinases. These TKIs are remarkably effective in the treatment of various human cancers including head and neck, gastric, prostate and breast cancer and several types of leukemia. However, these TKIs are transported out of the cell by ATP-binding cassette (ABC) transporters, resulting in development of a characteristic drug resistance phenotype in cancer patients. Interestingly, some of these TKIs also inhibit the ABC transporter mediated multi drug resistance (MDR) thereby; enhancing the efficacy of conventional chemotherapeutic drugs. This review discusses the clinically relevant TKIs and their interaction with ABC drug transporters in modulating MDR.
Study of Leaf Metabolome Modifications Induced by UV-C Radiations in Representative Vitis, Cissus and Cannabis Species by LC-MS Based Metabolomics and Antioxidant Assays
Authors: Marti Guillaume , Schnee Sylvain , Andrey Yannis , Simoes-Pires Claudia , Carrupt Pierre-Alain , Wolfender Jean-Luc , Gindro Katia
Published: September 2014

UV-C radiation is known to induce metabolic modifications in plants, particularly to secondary metabolite biosynthesis. To assess these modifications from a global and untargeted perspective, the effects of the UV-C radiation of the leaves of three different model plant species, Cissus antarctica Vent. (Vitaceae), Vitis vinifera L. (Vitaceae) and Cannabis sativa L. (Cannabaceae), were evaluated by an LC-HRMS-based metabolomic approach. The approach enabled the detection of significant metabolite modifications in the three species studied. For all species, clear modifications of phenylpropanoid metabolism were detected that led to an increased level of stilbene derivatives. Interestingly, resveratrol and piceid levels were strongly induced by the UV-C treatment of C. antarctica leaves. In contrast, both flavonoids and stilbene polymers were upregulated in UV-C-treated Vitis leaves. In Cannabis, important changes in cinnamic acid amides and stilbene-related compounds were also detected. Overall, our results highlighted phytoalexin induction upon UV-C radiation. To evaluate whether UV-C stress radiation could enhance the biosynthesis of bioactive compounds, the antioxidant activity of extracts from control and UV-C-treated leaves was measured. The results showed increased antioxidant activity in UV-C-treated V. vinifera extracts.
Retrievals of All-Weather Daily Air Temperature Using MODIS and AMSR-E Data
Authors: Jang Keunchang , Kang Sinkyu , Kimball John , Hong Suk
Published: September 2014

Satellite optical-infrared remote sensing from the Moderate Resolution Imaging Spectroradiometer (MODIS) provides effective air temperature (Ta) retrieval at a spatial resolution of 5 km. However, frequent cloud cover can result in substantial signal loss and remote sensing retrieval error in MODIS Ta. We presented a simple pixel-wise empirical regression method combining synergistic information from MODIS Ta and 37 GHz frequency brightness temperature (Tb) retrievals from the Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) for estimating surface level Ta under both clear and cloudy sky conditions in the United States for 2006. The instantaneous Ta retrievals showed favorable agreement with in situ air temperature records from 40 AmeriFlux tower sites; mean R2 correspondence was 86.5 and 82.7 percent, while root mean square errors (RMSE) for the Ta retrievals were 4.58 K and 4.99 K for clear and cloudy sky conditions, respectively. Daily mean Ta was estimated using the instantaneous Ta retrievals from day/night overpasses, and showed favorable agreement with local tower measurements (R2 = 0.88; RMSE = 3.48 K). The results of this study indicate that the combination of MODIS and AMSR-E sensor data can produce Ta retrievals with reasonable accuracy and relatively fine spatial resolution (~5 km) for clear and cloudy sky conditions.
Sources of China’s Economic Growth: An Empirical Analysis Based on the BML Index with Green Growth Accounting
Authors: Du Minzhe , Wang Bing , Wu Yanrui
Published: September 2014

This study develops a biennial Malmquist–Luenberger productivity index that is used to measure the sources of economic growth by utilizing data envelopment analysis and the directional distance function. Taking restrictions on resources and the environment into account based on the green growth accounting framework; we split economic growth into seven components: technical efficiency change, technological change, labor effect, capital effect, energy effect, output structure effect and environmental regulation effect. Further, we apply the Silverman test and Li-Fan-Ullah nonparametric test in combination with kernel distribution to test for the counterfactual contributions at the provincial level in China from 1998 to 2012. The empirical results show that: (1) technological progress and TFP make positive contributions to economic growth in China, while technical efficiency drags it down; (2) the effect of output structure and CO2 emissions with environmental regulation restrain economic growth in some provinces; and (3) overall, physical capital accumulation is the most important driving force for economic take-off, irrespective of whether the government adopts environmental regulations.
La dimension collaborative, un espace professionnel du maître E
Authors: Thomazet Serge , Merini Corinne
Published: September 2014

Entre aide directe à l’élève et aide indirecte, notre étude a pu identifier la position actuelle du maître E, certes dans l’école mais au seuil de la classe et montrer combien cette position « décalée » par rapport au centre de gravité de la classe était nécessaire pour construire des ruptures avec des situations difficiles. Cette position particulière lui offre des possibilités élargies de médiation et facilite les relations aux familles dont l’implication semble déterminante dans l’évolution de l’élève. L’espace professionnel dans lequel évolue le maître E croise une grande diversité de situations professionnelles. Certaines sont centrées directement sur l’élève (regroupement d’adaptation) ; d’autres sont orientées par l’élève mais partagées avec des partenaires au travers d’un PPRE par exemple. Partant d’une aide à l’élève, l’action du maître E peut viser, en même temps, le maître de la classe, au travers d’échanges formels ou informels ou encore de co-intervention, et les parents.
Screening for Metabolic and Reproductive Complications in Obese Children and Adolescents
Authors: Irizarry Krystal A. , Brito Valerie , Freemark Michael
Published: September 2014

Childhood obesity is associated with a number of metabolic comorbidities. These include glucose intolerance and type 2 diabetes mellitus, hyperlipidemia, fatty liver disease, and reproductive complications, such as polycystic ovary syndrome. The occurrence of these complications in a child or adolescent may result in progressive health decline at an early age. We, therefore, advocate screening and early diagnosis. This purpose of this review is to outline a rational, evidence-based approach to screening obese children and adolescents for metabolic and reproductive complications. In each section, the aim is to provide the primary care provider with a review of the literature supporting current screening practices. As such, this review is designed to assist the primary care provider in the selection and interpretation of screening tests and to make recommendations regarding the referral of patients for subspecialty care.[Pediatr Ann. 2014;43(9):e210–e217.]
Screening for Hormonal, Monogenic, and Syndromic Disorders in Obese Infants and Children
Authors: Mason Kelly , Page Laura , Balikcioglu Pinar Gumus
Published: September 2014

The prevalence of pediatric obesity in the United States is nearly 17%. Most cases are “exogenous”, resulting from excess energy intake relative to energy expenditure over a prolonged period of time. However, some cases of obesity are “endogenous”, associated with hormonal, genetic, or syndromic disorders such as hypothyroidism, Cushing’s syndrome, growth hormone deficiency, defective leptin signaling, mutations in the melanocortin 4 receptor, and Prader-Willi and Bardet-Biedl syndromes. This article reviews the hormonal, monogenic, and syndromic causes of childhood obesity and identifies critical features that distinguish “endogenous” obesity disorders from the more common exogenous obesity. Findings that raise suspicion for endogenous obesity include onset in infancy, lack of satiety, poor linear growth, dysmorphic features, and cognitive dysfunction. Selection and interpretation of appropriate laboratory tests and indications for subspecialist referral are also discussed.

[
Pediatr Ann
. 2014;43(9):e218–e224.]
Efficacy of Surgical Interventions for a Bipartite Patella
Authors: Matic George T. , Flanigan David C.
Published: September 2014

Educational objectives

As a result of reading this article, physicians should be able to:

1.

Identify common presenting characteristics of a symptomatic bipartite patella.

2.

Evaluate the most common surgical interventions used in the management of a symptomatic bipartite patella.

3.

Assess relief of symptoms and return to preoperative activity levels after surgical management of a bipartite patella.

4.

Identify complications from surgical management of a bipartite patella.

Bipartite patella is a relatively rare phenomenon. This anomaly is typically asymptomatic but can become painful with overuse, strenuous activities, or trauma, which is why it is typically seen in a young, athletic population. Although nonsurgical management is the initial treatment, if symptoms persist, surgical intervention may be necessary. Multiple surgical options exist, such as excision or fixation of the fragment or release of lateral soft tissue structures. The authors report the efficacy of various surgical interventions on a symptomatic bipartite patella, with outcomes related to symptom relief and ability to return to preoperative levels of activity. A systematic review was performed using multiple databases. Studies reporting outcomes of symptom relief or ability to return to activity following surgical intervention for a bipartite patella were included. Surgical technique, type of bipartite, and complications were recorded. Twenty-four articles with a total of 122 patients and 127 knees were included and reviewed. Relief of pain was achieved in 84.1% of patients, with 98.3% able to return to their preoperative activity levels after surgery. For patients with a symptomatic bipartite patella, return to preoperative activity levels with zero to minimal pain can be achieved with excellent results using any of the reported surgical methods. [
Orthopedics.
2014; 37(9):623–628.]
Single-plug Autologous Osteochondral Transplantation: Results at Minimum 16 Years’ Follow-up
Authors: Filardo Giuseppe , Kon Elizaveta , Di Matteo Berardo , Di Martino Alessandro , Marcacci Maurilio
Published: September 2014

Different techniques have been proposed for the treatment of cartilage defects. Among the currently available options, autologous single-plug osteochondral transplantation is one of the few to be applied to address small and medium lesions. The goal of the current study was to document the long-term clinical outcome of a cohort of patients treated by this surgical strategy, which consists of harvesting a single osteochondral plug from a less weight bearing area of the knee and implanting it on the defect site by press-fit technique. Fifteen patients were enrolled. Age at surgery was 30.2±15.3 years, and body mass index was 22.5±3.0 kg/m
2
. The inclusion criteria were clinical symptoms, such as knee pain or swelling, and grade III to IV chondral and osteochondral knee lesions. Patients were prospectively evaluated up to a mean of 17.5±3.5 years of follow-up by using Lysholm, International Knee Documentation Committee (IKDC) subjective, and Tegner scores. A significant improvement was noted in all clinical scores. In particular, the IKDC subjective score increased from 34.5±23.6 to 66.3±26.4 (
P
=.001). The Lysholm score showed a similar trend. From a baseline value of 47.8±29.5, the score increased to 79.8±24.6 at the last evaluation (
P
=.001). A significant increase in Tegner score was observed at the 2-year evaluation, with stable results up to the last follow-up. Four failures were reported, which in 3 cases occurred at mid- to long-term follow-up, confirming that this technique can be considered a suitable option for the treatment of small and medium chondral and osteochondral lesions in young patients.