bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase II study of interrupted and continuous dose lenalidomide in relapsed/refractory Hodgkin lymphoma
Authors: Fehniger Todd A. , Watkins Marcus P. , Ezenwajiaku Nkiruka , Wan Fei , Hurd David D. , Cashen Amanda F. , Blum Kristie A. , Goy Andre , Fenske Timothy S. , Wagner-Johnston Nina D. , Carson Kenneth , Siegel Marilyn J. , Russler-Germain David , Schneider Stephanie E. , Mehta-Shah Neha , Kahl Brad , Bartlett Nancy L.
Published: September 2023

Not available.
Treg-targeted IL-2/anti-IL-2 complex controls graft-versus
-host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation
Authors: Thiolat Allan , Pilon Caroline , Caudana Pamela , Moatti Audrey , To Nhu Hanh , Sedlik Christine , Leclerc Mathieu , Maury Sébastien , Piaggio Eliane , Cohen José L
Published: September 2023

Modulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity of donor T cells and hematologic malignancy relapse while controlling the potential development of graft-versus-host disease (GVHD), in which donor T cells attack the recipient's tissues. IL-2/anti-IL-2 complexes (IL2-Cxs) represents a therapeutic option to selectively accentuate or dampen the immune response. In dedicated experimental models of allo-HSCT, including also human cells injected in immunodeficient NSG mice, we evaluated side-by-side the therapeutic effect of two IL-2Cxs designed either to boost regulatory T cells (Tregs) or alternatively to activate effector T cells (Teffs), on GVHD occurrence and tumor relapse. We also evaluated the effect of the complexes on the phenotype and function of immune cells in vivo.
Unexpectedly, both pro-Treg and pro-Teff IL-2Cxs prevented GVHD development. They both induced Treg expansion and reduced CD8+ T cells numbers, compared to untreated mice. However, only mice treated with the pro-Treg IL-2Cx, showed a dramatic reduction of exhausted CD8+ T cells, consistent with a potent anti-tumor effect. When evaluated on human cells, pro-Treg IL-2Cx also preferentially induced Treg expansion in vitro and in vivo, while allowing the development of a potent antitumor effect in NSG mice.
Our results demonstrated the clinical relevance of using a pro-Treg, but not a pro-Teff IL2/anti-IL-2 complex to modulate alloreactivity after HSCT, while promoting a GVL effect.
Amphiregulin as monitoring biomarker for life-threatening acute graft-versushost disease: secondary analysis of two prospective clinical trials
Authors: Holtan Shernan G. , El Jurdi Najla , Rashidi Armin , Betts Brian C. , Demorest Connor , Galvin John P , MacMillan Margaret L. , Weisdorf Daniel J. , Panoskaltsis-Mortari Angela , Pratta Michael A.
Published: September 2023

Not available.
Pemanfaatan Tanaman Obat Keluarga Sebagai Upaya Peningkatan Produktivitas Peserta Sekolah Perempuan Kelopak Gayatri Desa Gumelem Kulon Banjarnegara
Authors: Kurochman Sal Sabila Nadhifah , Injelita Joya , Azizah Adinda Fayi , Yulanda Revalina Avrillia , Afifudin  , Sundhani Elza
Published: September 2023

Pemanfaatan Tanaman Obat Keluarga (TOGA) sebagai salah satu alternatif pengobatan yang sangat potensial dikembangkan oleh masyarakat pedesaan. Luasnya lahan dan pekarangan di pedesaan dapat dimanfaatkan untuk dijadikan lahan TOGA, namun masyarakat tidak memiliki ilmu dan ketrampilan yang cukup. Kegiatan ini bertujuan untuk memberikan edukasi tentang khasiat TOGA dan cara mengolah lahan disekitar rumah untuk menjadi tempat budidaya TOGA pada kelompok sekolah perempuan kelopak Gayatri Desa Gumelem Kulon Banjarnegara. Metode yang digunakan meliputi penyuluhan tentang manfaat dan cara pengolahan serta praktek menanam TOGA. Hasil yang dicapai dari kegiatan ini yaitu meningkatnya pemahaman tentang jenis tanaman TOGA, klasifikasinya, cara pengolahan, pemanfaatan TOGA serta pentingnya tanaman TOGA untuk pengobatan serta mendapatkan ketrampilan berbudidaya TOGA dengan memanfaatkan pekarangan dan kebun disekitar rumah untuk menjadi tempat budidaya TOGA. Adanya kebun TOGA yang merupakan hasil luaran pengabdian ini selanjutnya diharapkan dapat dimanfaatkan untuk pengobatan atau dapat digunakan untuk memperbaiki perekonomian dengan menjual hasil TOGA.
Transformasi Digital UKM Dimar Kerupuk Kulit Ikan Kakap Desa Kidul Dalem Kecamatan Bangil Kabupaten Pasuruan
Authors: Azizah Zahrotul , Fitrianah Listin , Editya Arda Surya
Published: September 2023

Peningkatan kapasitas produksi UKM Dimar kerupuk kulit ikan kakap melalui upgrade alat produksi dapat meningkatkan daya saing dan pemasaran. Proses pengeringan yang masih mengandalkan sinar matahari seringkali terhambat saat musim hujan. Penggunaan alat pengering kerupuk dengan konsep Internet of Things (IoT) dapat mengatasi masalah ini guna meningkatkan efisiensi dan kualitas produk. Metode pelaksanaan yaitu pengadaan alat pengering kerupuk dan alat IoT, pemasangan alat IoT pada alat pengering kerupuk, pembuatan website untuk mitra, pelatihan media pemasaran dan pengisian konten website, dan pelatihan penggunaan alat pengering kerupuk berbasis IoT. Hasil pelaksaan pengabdian adalah mitra dapat mempersingkat waktu pengeringan. Rata-rata efisiensi waktu dengan adanya sistem pengering berbasis IoT sebesar 60%. Selain implementasi IoT pada alat pengering kerupuk, pembuatan website dan pelatihan pemasaran juga menjadi langkah kunci untuk mendukung pertumbuhan UKM Dimar. Kombinasi ini membuat UKM Dimar dapat mencapai audiens yang lebih luas, meningkatkan penjualan, dan tetap bersaing di pasar kerupuk yang semakin kompetitif.
Predictive Factors for Retreatment after Intravitreal Ranibizumab Injection to Treat Type 1 Retinopathy of Prematurity
Authors: Park Su Hwan , Byon Iksoo , Kwon Han Jo
Published: September 2023

Purpose: To investigate predictive factors for retreatment after intravitreal ranibizumab injection as first-line treatment for retinopathy of prematurity (ROP).Methods: The medical records of consecutive infants diagnosed with type 1 ROP from 2013 to 2021 who received 0.2 mg intravitreal ranibizumab as their first treatments were retrospectively reviewed. Only eyes with severe ROP were included. Retreatment was performed if eyes again met the criteria for type 1 ROP or presented with stage 3 ROP and the plus sign. Factors around the time of first injection that predicted retreatment were assessed.Results: Intravitreal ranibizumab was injected into 44 eyes of 44 infants. The mean gestational age (GA) and body weight were 27.8 weeks and 1,046.6 g, respectively. Retreatment was required by 21 eyes (47.7%) at an average of 8.9 weeks after the first injection, thus at 37.2 weeks of mean postmenstrual age. The retreatment group exhibited a lower GA (p = 0.036), lower 1 minute (min) (p = 0.014) and 5 min (p = 0.029) Apgar scores, and more quadrants with plus signs (p = 0.044) before the first injections; they also had a longer period of oxygen requirement (p = 0.001), more loss of the plus sign (p = 0.014), and more ROP involution (p = 0.003) after the first injections. The risk of needing retreatment increased with a lower 1 min Apgar score (p = 0.010, odds ratio [OR] = 2.04) and later disappearance of the plus sign (p = 0.013, OR = 1.44) after the first injection.Conclusions: About half of patients with type 1 ROP may require retreatment 2 months after the first ranibizumab injection. Delayed loss of the plus sign increases the risk of retreatment; careful fundus examination is recommended after the first injection.
Four-flanged Technique for Scleral Fixation of a Dislocated Four-eyelet Intraocular Lens
Authors: Lim Byung Su , Kwon Jun Su , Won Jae Yon
Published: September 2023

Purpose: To define and evaluate the short-term clinical outcomes of the four-flanged technique for scleral fixation of a dislocated four-eyelet intraocular lens (IOL).Methods: Eleven eyes of 11 patients who underwent scleral fixation of dislocated four-eyelet intraocular lenses using a four-flanged technique were studied retrospectively. We measured the best-corrected visual acuity (BCVA), corneal endothelial cell density, intraocular pressure (IOP), spherical equivalent, astigmatism, IOL tilt and decentration, and postoperative complications.Results: The BCVA was 0.25 ± 0.11 logarithm of the minimal angle of resolution (logMAR) before surgery and 0.14 ± 0.12 logMAR 6 months later (p < 0.001). The corneal endothelial cell count was 2,427 ± 384 and 2,367 ± 298/mm2 before and after surgery, respectively (p = 0.285). The spherical equivalent was 6.02 ± 4.90 and 0.11 ± 0.36 before and after surgery, respectively. There was no significant difference in astigmatism before and after surgery. The mean IOL tilt and decentration were 2.44 ± 1.68° and 0.23 ± 0.09 mm, respectively. The refractive difference was 0.11 ± 0.24 diopters (D). Postoperative complications occurred in one eye; one flange lay outside the scleral tunnel, triggering hyperemia and conjunctival inflammation.Conclusions: The four-flanged scleral fixation technique for a dislocated four-eyelet IOL improved the BCVA but did not significantly affect corneal endothelial cell loss. The procedure significantly reduced postoperative IOL tilt, decentration, and astigmatism, and may be a useful alternative to scleral fixation of a dislocated four-eyelet IOL.
Short-term Efficacy and Safety of Omidenepag Isopropyl 0.002% w/v Therapy for Patients with Primary Open-angle Glaucoma and Ocular Hypertension
Authors: Kim Jung Soo , Kim Jung Lim
Published: September 2023

Purpose: To analyze the short-term efficacy and safety of omidenepag isopropyl 0.002% (w/v) in patients with primary open-angle glaucoma and ocular hypertension.Methods: Data on 36 patients with primary open-angle glaucoma and ocular hypertension treated with omidenepag isopropyl 0.002% (w/v) from January 2021 to May 2022 were retrospectively analyzed. We investigated whether the drug lowered the intraocular pressure (IOP) at 1 and 3 months compared to baseline. Possible side effects were sought at each visit.Results: The mean patient age was 59.2 years at the time of treatment. Of the 36 patients, 33 had primary open-angle glaucoma and 3 had ocular hypertension. The baseline IOP was 15.9 ± 3.6 mmHg, which significantly decreased to 13.7 ± 2.8 and 13.4 ± 2.9 mmHg at 1 and 3 months, respectively, following instillation of omidenepag isopropyl 0.002% (w/v) (both p < 0.01). Twelve patients (29.2%) experienced side effects including hyperemia, ocular pain, and itching but only two (5.5%) stopped using the medication.Conclusions: In the short-term, ominedepag isopropyl 0.002% (w/v) is effective and safe in patients with primary open-angle glaucoma and ocular hypertension.
Relationship between Thyrotropin Binding Inhibitory Immunoglobulin and Strabismus-associated Thyroid Eye Disease Stability
Authors: Hwang Jae Yul , Sung Jae Yun , Kim Min Su , Lee Yeon-Hee
Published: September 2023

Purpose: To investigate the relationship between thyrotropin binding inhibitory immunoglobulin (TBII) and deviation angle stability in strabismus-associated thyroid eye disease.Methods: A total of 25 strabismus-associated thyroid eye disease patients who were followed up for > 6 months without surgery were enrolled. To investigate the correlation between TBII levels and changes in the deviation angle, a test period of 6 months from the date of TBII measurement was established and 55 test units of the corresponding TBII levels were obtained.Results: The deviation angle had a positive correlation with the TBII levels (r = 0.473, p < 0.001), but did not correlate with sex, age, and thyroid hormone levels. Changes in the horizontal, vertical, and total deviation angles were significantly greater in the high-TBII test units compared to the normal-TBII test units (p= 0.029, = 0.032, and = 0.009, respectively).Conclusions: TBII levels were related to deviation angle stability in strabismus-associated thyroid eye disease. TBII may be a useful indicator for deviation angle stability in these patients over a period of 6 months.
Changes in Angle of Exodeviation According to Distance after Monocular Occlusion in Intermittent Exotropia
Authors: Park Moon Young , Shin Hyun Jin
Published: September 2023

Purpose: This study investigated changes in the angle of exodeviation at different distances and the characteristics of a group that showed an increased angle following monocular occlusion in intermittent exotropia.Methods: In all, 102 patients diagnosed with basic intermittent exotropia were enrolled. The deviation angle was measured using a mirror at 33 cm, 3 m, 6 m, 12 m, and 6 m. Moreover, the deviation was measured at 33 cm and 3 m after patching the non-dominant eye for 1 hour. Patients with a higher deviation angle at 33 cm after occlusion were categorized as the ‘increased group’, whereas those with lower deviation angles were classified as the ‘stationary group’.Results: There was a male-to-female ratio of 46:56 and an average age at surgery of 9.23 years. No significant differences were observed in deviation measurements taken at 3, 6, 12, and 6 m using a mirror. However, after occlusion, there was a significant increase in deviation at 33 cm (p < 0.01). The average log value of near stereoacuity was 1.96 ± 0.35 in the increased group and 2.16 ± 0.41 in the stationary group. The group with an increased near deviation after occlusion demonstrated a significantly improved near stereoacuity (p = 0.01) and an increased proportion of good results in the near Worth 4 dot test (p = 0.03).Conclusions: Preoperative measurement of maximum deviation after 1 hour of monocular occlusion can help reduce recurrence and insufficient correction, particularly in patients with good fusional ability.
Neovascular Glaucoma as the Initial Presentation of Ocular Tuberculosis
Authors: Cho Yongwun , Kwon Jeongwoo , Seo Jin-Seok , Kim Gyu-Nam , Yoo Woong-Sun , Chung In Young
Published: September 2023

Purpose: To report a case of ocular tuberculosis that first manifested as neovascular glaucoma.Case summary: A 76-year-old male visited our hospital complaining of decreased visual acuity in the left eye. He had undergone tuberculosis treatment 1 year prior, and had been cured. At the time of his visit, decreased visual acuity, increased intraocular pressure, and iris neovascularization were observed in the left eye. He was diagnosed with neovascular glaucoma and was started on treatment to lower the intraocular pressure. At the time of the visit, we also noticed vitreous opacity in both eyes. The patient did not attend his scheduled follow-up visit, but returned 2 months later complaining of decreased visual acuity in both eyes. The vitreous opacity in the retinae of both eyes had become aggravated. Diagnostic vitrectomy was performed on both eyes, and multiple yellowish-white circular lesions were observed throughout the retinae. Systemic abnormalities were suspected, and thus additional tests were performed. Bronchoalveolar lavage fluid analysis revealed recurrence of pulmonary tuberculosis, and tuberculosis treatment was recommenced. Temporary increases in ocular inflammation and deterioration were observed but improved after the addition of systemic steroids. The patient has been under observation without recurrence for about 1 year.Conclusions: Ocular tuberculosis can be expressed in the form of neovascular glaucoma, so ocular tuberculosis should be suspected if there is a history of tuberculosis and abnormal retinal findings.
UNLIMITED LISTS OF QUADRATIC INTEGERS OF GIVEN NORM APPLICATION TO SOME ARITHMETIC PROPERTIES
Authors: GRAS Georges
Published: September 2023

We use the polynomials $m_s(t) = t^2 - 4 s$, $s \in \{-1, 1\}$, in an

elementary process giving unlimited lists of {\it fundamental units of norm $s$},

of real quadratic fields, with ascending order of the discriminants.

As $t$ grows from $1$ to an upper bound $\BB$, for each {\it first occurrence}

of a square-free integer $M \geq 2$, in the factorization $m_s(t) =: M r^2$, the

unit $\frac{1}{2} \big(t + r \sqrt{M}\big)$ is the fundamental unit of norm $s$

of $\Q(\sqrt M)$, even if $r >1$ (Theorem \ref{fondunit}).

Using $m_{s\nu}(t) = t^2 - 4 s \nu$, $\nu \geq 2$, the algorithm gives unlimited

lists of {\it fundamental integers of norm $s\nu$} (Theorem~\ref{unicity}).

We deduce, for any prime $p>2$, unlimited lists of {\it non $p$-rational}

quadratic fields (Theorems \ref{prational}, \ref{heuristic}, \ref{infty}) and lists

of degree $p-1$ imaginary fields with non-trivial $p$-class group (Theorems

\ref{cubic}, \ref{quintic}). All PARI programs are given.
O aquecimento turístico de Tibau/RN: Um estudo de caso sobre segunda residência
Authors: Oliveira Vera Lúcia Lopes de , Nascimento Cláudia Regina Tavares do
Published: September 2023

O estudo tem por objetivo analisar o impacto da segunda residência para o aquecimento turístico durante o período de veraneio no município de Tibau, no Rio Grande do Norte. A relevância do estudo centra-se em expor os impactos causados pela existência da segunda residência na zona litorânea de Tibau, levantando os pontos positivos e negativo, a relação entre visitantes e habitantes e o aquecimento turístico. A metodologia utilizada foi o estudo de caso descritivo/exploratório, com métodos qualitativos, com análise os dados quantitativos coletados durante a pesquisa de campo e aplicação do questionário. Os dados serão expostos por gráficos, identificando os principais pontos dos questionários. A análise qualitativa foi realizada com base na pesquisa bibliográfica, documental e pesquisa de campo. Com os resultados fica claro a relação entre as pessoas que residem na cidade de Tibau com aquelas que vão apenas em períodos livre, e foi possível detectar o aquecimento do turismo local através do aumento considerável nas vendas de serviços e produtos disponíveis no município durante esse período, onde o fluxo de visitantes/usuários desses imóveis usufruir desses serviços e produtos contribuindo assim para o incremento da atividade turística na localidade. Entretanto, a pesquisa constatou que apesar da presença contínua da segunda residência, o aquecimento do turismo acontece apenas nas épocas de veraneio, devido aos moradores e visitantes que ocupam essas residências. No entanto, no restante do ano, por esses imóveis permanecerem fechado a maior parte do tempo, o fluxo é menor e o aquecimento turístico.
A educação alimentar e nutricional como estratégia para a prevenção da obesidade infantil
Authors: Moura Ana Luisa Claro de
Published: September 2023

Introdução: A obesidade infantil é considerada um problema de saúde pública, com prevalência crescente e caracterizada pelo acúmulo excessivo de gordura nos tecidos adiposos. Vários fatores podem estar relacionados à alta prevalência como influências familiares, sedentarismo e aspectos culturais. Diante disso, a Educação Alimentar e Nutricional (EAN) no ambiente escolar, onde as crianças passam a maior parte do seu dia, é considerada uma estratégia para combater essa realidade. Objetivo: Averiguar como a educação alimentar e nutricional pode contribuir para diminuir os índices de obesidade infantil. Métodos: O estudo em questão é uma revisão narrativa de literatura, com abordagem qualitativa. Nas estratégias de buscas foram utilizadas como base de dados: Google acadêmico, Scielo e Pubmed. Resultados e Discussão: Nas últimas décadas aumentou-se o número de crianças que são expostas diariamente a alimentos ultraprocessados, sendo esta uma das causas para o aumento da obesidade infantil. Estudos mostram que há um grande percentual de contato com esses alimentos desde a primeira infância e que existe vários fatores que podem influenciar o comportamento alimentar. Devido às causas multifatoriais da obesidade destaca-se a necessidade de um tratamento realizado por uma equipe multidisciplinar, destacando-se a ação do nutricionista por meio das ações de EAN. Conclusão: Conclui-se que as ações de EAN são de extrema importância na formação de bons hábitos alimentares e na diminuição da prevalência de obesidade infantil.
Adesão à terapia antirretroviral por pacientes com HIV no Brasil e fatores que a prejudicam: uma revisão integrativa
Authors: Techi Lucas de Carvalho , Cavalcante Igor dos Santos , Lima Danilo Andrade , Oliveira Jocerone Emerson Nogueira , Lopes Samuel Davi Sousa , Mendes João Pedro Sousa , Nogueira Tiago Lima , Mendes Erica de Araújo Silva
Published: September 2023

Objetivo: Analisar e sintetizar os fatores relacionados à adesão da terapia antirretroviral (TARV) em portadores de HIV/AIDS no Brasil e as suas principais barreiras de continuidade. Metodologia: Revisão integrativa de literatura utilizando as bases de dados Scientific Eletronic Library Online (SciELO), PUBMED e Literatura Latino-Americana e do Caribe (LILACS) a partir da combinação dos Descritores em Ciências da Saúde (DeCS/MeSH). Resultados:  A TARV representa a principal forma de controle da infecção pelo HIV, tornando sua adesão um processo complexo e multifatorial. Os primeiros seis meses de tratamento são determinantes no sucesso da aderência das medicações. Entretanto, a regularidade do uso da TARV perpassa por diversas condições, como: contexto social, renda, escolaridade, efeitos adversos, estigma, uso de álcool e outras drogas, além de rede de apoio e receptividade no sistema de saúde. Por isso, para que haja uma continuidade do processo terapêutico, faz-se imprescindível o acolhimento efetivo e identificação das demandas dos usuários no serviço de saúde, para que esses se sintam seguros e incentivados a permanecer em tratamento. Conclusão: Segundo o levantamento realizado, percebeu-se uma fragilidade na adesão à TARV, o que chama a atenção para medidas de intervenção, tais como: entrevista motivacional, uso de aplicativos móveis, SMS e chamadas telefônicas, contribuindo para a prática assistencial e o acompanhamento integral em saúde desses indivíduos.
Avaliação da qualidade de vida de pacientes submetidos à escleroterapia com espuma de polidocanol na região oeste de Santa Catarina
Authors: Leocovick Luã , Valdameri Leonardo Antônio , Siliprandi Vinicius , Dornelles Alex Lazzari , Schinco Fernando Bonetto
Published: September 2023

O tratamento de escleroterapia com espuma de polidocanol tem sido utilizado para portadores de insuficiência venosa crônica (IVC) como forma menos invasiva de tratamento. Neste estudo será visto como ele influência no quadro clínico e também na qualidade de vida do paciente portador de IVC. O objetivo do estudo é avaliar pacientes que foram submetidos a escleroterapia com espuma de polidocanol e mensurar os resultados encontrados. Foram avaliados prontuários de pacientes submetidos ao tratamento de escleroterapia com espuma de polidocanol nos anos de 2016 a 2020, através do questionário VEINES-QOL/Sym. O total de 71 prontuários foram analisados, tendo como idade média de 54 anos, dos quais 80,28% eram do sexo feminino. A média de aplicações foi de 3,44 para cada paciente e o volume médio foi de 22,75 ml de espuma de polidocanol por indivíduo. Este estudo demonstrou melhoras significativas nos sintomas e na qualidade de vida dos pacientes portadores de IVC que fizeram o tratamento com espuma de polidocanol, podendo ser observado pela melhora global nos questionários respondidos pelos pacientes após 30 dias de tratamento.
COVID-19 SEVERITY PREDICTION USING DEEP LEARNING MODELS – COMPARATIVE STUDY
Authors: Goyal Aviral , Magadum Hrishikesh , Srivastava Sanskriti , Patel Harpal , N Dr.Jaisankar ,   Vellore Institute of Technology, Vellore, India
Published: September 2023

In response to the exponential rise in COVID19 instances, healthcare professionals have been seeking for strict automated detection measures to stop COVID from spreading while simultaneously attempting to restrict device processing needs. Additionally, we must comprehend the severity of the COVID infection based on the harm the infection has done to the lungs to properly treat impacted individuals. We choose a suitable CNN model as a result after performing an initial comparison analysis of many well-known CNN models. Using a dataset generated from sources like prior papers and other internet resources, this study provides an ensemble model that is exact and effective and is built on deep learning Convolutional Neural Networks (CNN). The dataset is altered in several ways to boost its accuracy. To choose the optimal deep-learning model for our application, we are performing a comparative study. We assessed the benefits and drawbacks of many commercial CNN models, including VGG16, VGG19, and Densenet 121. To select the optimal model for provided dataset, the accuracy comparative study is constructed. VGG16 model had highest accuracy, coming in at 82.46 %. The study was conducted to determine the optimum way for our multi-modal picture classification, which, with a little modification, functions well, rather than to accurately assess how well each method did.
Nonlinear Singularly Perturbed Cauchy Problem With Inner Layer
Authors: Erkebaev U. , Sulaimanov Z.
Published: September 2023

In the article, the asymptotics of the solution of the Cauchy problem for a nonlinear autonomous ordinary differential equation of the first order, which is a simple mathematical model with an inner layer, is constructed. For all theoretical calculations, evidence-based calculations in the Maple system are given.
Phytocoenological Characteristics and Importance of Vegetation on the Territory of Lerik District (Azerbaijan)
Authors: Aslanova S.
Published: September 2023

In modern times, the study of vegetation from an ecological-geobotanical or phytocoenological point of view is of great importance for the effective use of natural phytocenosis that are part of the biocenosis, as well as for the implementation of the tasks of their protection on a scientific basis. In accordance with the requirements of the Law of the Republic of Azerbaijan “On State Land Cadastre, Land Monitoring and Land Arrangement”, as well as “On the Implementation of the State Program for the Efficient Use of Summer and Winter Pastures, Hayfields and Prevention of Desertification in the Republic of Azerbaijan” of the President of the Republic of Azerbaijan dated May 22, 2004 year, in accordance with the implementation of the decree of 2011, geobotanical or phytocoenological studies are carried out on summer meadows. In the studies carried out, the ecological and phytocoenological indicators of the vegetation of the mountainous part of Talysh (on the territory of the Lerik district) were studied and it was found that mountain-meadow and mountain-steppe vegetation is predominantly distributed in the district. On a wider range, 4 formations formed by them are distributed: Stipetum-Festucosum, Astracantheta-Thymusetum-Festucosum, Astracanthetum and Festuceta-Achilletum-Astracalosum. As a result, ways of efficient use of the mountain ecosystem of the Lerik district were discussed.
Infection of Pigs by Associative Invasion
Authors: Nasibov M.
Published: September 2023

The article deals with research work carried out in pig-breeding farms located in the Gabala district on the infection of pigs from helminthiasis with metastrongylosis and strongyloidosis, from diseases caused by primary intestinal parasites — eimeriosis, depending on age and season. During the study in the spring period, infection with metastrongylosis was detected in 2-6-month-olds 36.4%, in 7-12-month-olds 38.5%, in mature animals 25.0%; with strongylodiosis in 2-6-month-olds 27.3%, in 7-12-month-olds 30.8%, in mature animals 16.7%; from diseases caused by primary intestinal parasites, - eimeriosis in 2-6-month-olds 54.5%, in 7-12-month-olds 38.5%, in mature animals 25.0%; in summer period infection with metastrongylosis in 2-6-month-olds 30.0%,in 7-12-month-olds 33.3%, in mature animals 27.3%; with strongylodiosis in 2-6-month-olds 20.0%, in 7-12-month-olds 25.0%, in mature animals, 18.2%; infection with eimeriosis in 2-6-month-olds 20.0%, in 7-12-month-olds 8.3%, and in mature animals during the examination, infection was not detected. In the autumn period, infection with metastrongylosis was studied in 2-6-month-olds 45.5%, in 7-12-month-olds 50.0%, in mature animals 30.0%; infection with strongyloidosis in 2-6-month-olds 36.4%, in 7-12-month-olds 35.7%, in mature animals 20.0%; with eimeriosis in 2-6-month-olds 45.5%, in 7-12-month-olds 35.7%, in mature animals 30.0%; and in winter period infection with metastrongylosis in 2-6-month-olds 23.1%, in 7-12-month-olds 20.0%, in mature animals 18.2%; with strongyloidosis in 2-6-month-olds 15.4%, in 7-12-month-olds 10.0%, in mature animals 9.1%; infection with eimeriosis in 2-6-month-olds 23.1%, in 7-12-month-olds 20.0%, in mature animals 9.1%. Summarizing the results obtained, infection with metastrongylosis was detected in the spring period of 33.3%, in summer 30.3%, in autumn 42.9%, and in winter 20.6%; infection with strongyloidosis in spring 25.0%, in summer 21.2%, in autumn 31.4%, and in winter 11.8%; infection with eimeriosis in spring 38.9%, in summer 9.1%, in autumn, 37.1%, and in winter was 17.6%.
Modern Ideas on the Role of Macrophages and Neutrophils in the Development of Endometriosis
Authors: Martynova L. , Chaulin A. , Vankov V. , Grigoryeva Yu.
Published: September 2023

Endometriosis is one of the most common gynecological diseases. Methods of diagnosis and treatment of endometriosis are imperfect, which is probably due to insufficient knowledge of the pathogenesis of this disease. Recently, research efforts have focused on the study of immunoinflammatory mechanisms in the development and progression of endometriosis. Understanding the pathogenetic mechanisms of endometriosis is important for the discovery of new laboratory biomarkers for early diagnosis and new targets for therapeutic effects. This article summarizes information on the role of some of the main cells of the immune system (macrophages and neutrophils) in the pathogenesis of endometriosis.
Internet User Awareness Assessment on the Impact of Microplastics on Health
Authors: Kobzar V. , Serebryakova Yu. , Raimkulova D. , Shekerbekova A.
Published: September 2023

Microplastics are very small particles, less than 5 microns in size, which is 40-120 times thinner than a human hair. The nanoplastic has a size of less than 0.001 microns. The UN Environment Assembly in 2022 was dedicated to the problem of plastic pollution. WHO called on the scientific community to study the direct and indirect effects of microplastics on human health, and bloggers and social networks to raise awareness on this issue. The main purpose of the article was to assess the level of awareness of the problem of the impact of microplastics on human health by questioning a heterogeneous audience of Internet users. Our specially designed questionnaire consisted of 26 multiple choice questions. The representative sample included the answers of 281 respondents aged 15-50 years. Statistical processing of the obtained results was carried out using the SPSS software. This survey reflected gaps in knowledge regarding the routes of entry into the body and the environment, the sources of microplastics, and its impact on the development of specific diseases. In general, respondents are well aware of the negative direct and indirect effects of plastic, but due to convenience, habit and lack of alternatives, they still use it widely. Increasing the knowledge and awareness of the general population will increase the perception of the risk of disease and increase their actions to reduce microplastic pollution. Only 24.4% of respondents were in favor of actively reducing the use of plastic products. 42.4% of survey participants are still at the level of awareness of the problem and attempts to reduce plastic consumption. 57.7% of respondents believe that plastic products are used daily, forgetting that we live in a plastic world. As the results of the survey showed, respondents most often received information about the dangers of microplastics from social networks 52.4%, news — 36.9%, Google search engine — 35.94%, scientific articles — 29.2%, while communicating with friends, family — 22.9%. The respondents’ responses reflected their frequent use of food packaging, cosmetics and hygiene products, and plastic bags. Therefore, the most common current actions to reduce the use of plastic products are replacing sustainable alternatives and choosing products with less plastic packaging. Respondents were most aware of the impact of microplastics on the development of diseases such as cancer (37.8%); chronic inflammation (36.6%); inflammatory bowel disease (31.8%,), allergic diseases (31.1%) and respiratory problems (25.8%). A comprehensive and collaborative approach by governments, scientists, manufacturing companies and public health authorities to increase the sustainable production, use and disposal of plastics is essential to limit their subsequent harmful effects on human health.
Designing of a Cavitation Heat Generator for Heating Water With a Capacity of 10 kW
Authors: Wan Shiqing , Bazhanov A. , Qian Zhipeng
Published: September 2023

This article establishes a three-dimensional model of the design circuit of a water heating cavitation device and simulates it in Hysys software. The relationship between temperature, pressure and flow rate of cavitation generator in pulsed heating water circulation unit is studied by using control variables. The dependence of pressure and temperature difference on flow rate was studied. The dependence of pressure and temperature difference on the thermal power of the cavitation device was studied. The dependence of pressure and temperature differences on pipeline diameter was investigated. Explored the differences in pressure and temperature through water flow methods in pulse and stationary modes. The following conclusions can be drawn: 1) When the flow rate and output thermal power remain constant, the pipe diameter is inversely proportional to the pressure; 2) When the pipe diameter and output thermal power remain constant, the flow rate is proportional to the pressure; 3) When the total output power is 10 kW, the outlet temperature of the system gradually rises to a relatively stable state after 1000 seconds for different power cavitator schemes; 4) When the total output power is basically equal, the more times the parallel connection is made, the smaller the voltage drop, and the higher the system efficiency; 5) When the pipe diameter and output heat power are constant, the larger the flow rate, the smaller the temperature after the cavitator and the temperature difference between the front and back become smaller. When the pipe diameter and flow rate are constant, the smaller the output thermal power, the smaller the temperature after the cavitator and the temperature difference between the front and back become smaller.
Performance Functions of the Flashback Category in Artistic Text
Authors: Biygeldieva N.
Published: September 2023

In the article, on a scientific and theoretical basis, the performing functions of the category of retrospection in a literary text are revealed. In order to comprehensively study the category of retrospection, it is not enough to analyze only its structural (formal) aspect, it should be considered in an in-depth study, as part of a holistic text, in its dynamic aspect. The retrospective category is a functional-stylistic category; in its analysis, the main goal is to consider its linguistic means, spatial structure, and functional aspect. The originality of the functions of the category of retrospection lies in the issue of a communicative-cognitive plan (to achieve an adequate understanding of the text) and the law of logical (artistic) thinking, i.e. the presence of an “old” concept, which is generalized and emphasized in the course of a logical discussion in the dynamics of the verbal-thinking process.
Variability in Virulence of Wheat Leaf Rust (Puccinia triticina) in the Sindh Province, Pakistan
Authors: Channa Abdul W. , Bux Hadi , Sial Mahboob A. , Jatoi Ghulam H. , Korejo Farzana , Ali Umed , Shah Syed M. A. , Koondhar Naimatullah , Mastoi Amir A. , Figari Isabel M. G. , Keerio Muhammad A.
Published: September 2023

Leaf rust of wheat caused by an obligate biotrophic fungus (Puccinia triticina), is one of the widespread diseases of wheat. The emergence of new virulent races of fungal pathogens threatens wheat cultivars’ resistance, leading to outbreaks that can cause substantial damage to crops and result in economic losses to farmers. Developing wheat cultivars that have resistance to virulent races is an effective means of reducing the frequency and impact of these outbreaks. An experiment was conducted at 5 locations (a trap nursery consisting of 37 lines of wheat leaf rust differentials and 115 commercial wheat cultivars was established against leaf rust pathogen), for evaluating the virulence pattern of leaf rust under natural field environments across wheat-producing regions of Sindh, Pakistan. Results revealed that Lr9, Lr19 and Lr28 genes were found effective under field environments. The  moderate resistance was recorded for Lr18, Lr23 and Lr34 genes at two locations while Lr36 Lr37 genes had moderate resistance at most of the locations. Results also revealed that Rawal-87, Marvi-2000, Bhittai, Pirsabak-08, Faisalabad-08, Benazir-13 and Shalakot-13 were the commercial wheat varieties having resistance at all locations of Sindh during (year 1 and year 2) years while most of the cultivars showed susceptibility. The scenario clue to a dire necessity to widen the genetic base of Pakistani cultivars by incorporating genes for the resistance against disease. Furthermore, strong monitoring and regular surveys should be conducted for determining current virulence status and resistance genes.
Epidemiology of Rice Blast (Pyricularia oryzae) Disease in Central Punjab, Pakistan
Authors: Arooj Saneela , Ahmad Salman , Akhter Muhammad , Atiq Muhammad , Rashid Abdul , Ehetisham Ul Haq Muhammad , Rehman Malik A. , Kamran Muhammad , Intisar Anum , Asim Muhammad
Published: September 2023

Rice blast disease (RBD) is mostly controlled by fungicides by the farmers of central Punjab, Pakistan. However, the use of fungicides by the farmers is excessive and ill-advised, resulting in the emergence of new resistant strains of Pyricularia oryzae. The ill-advised employment of fungicides can be timed exploring the role of environmental factors favourable for this disease. The objective of current study was to determine the most favourable weather conditions for RBD in central Punjab, Pakistan, where this crop is mostly cultivated. Environmental factors including maximum and minimum temperatures (max and min temp), rainfall (Rf), relative humidity (Rh) and wind speed (Ws) conducive for RBD were characterized during this study. For this purpose, eight years (2009-2016) RBD severity data of susceptible to highly susceptible genotypes together with environmental data (max and min temp, Rf, Rh and Ws) was collected from Kala Shah Kako (KSK), Rice Research Institute (RRI), Punjab, Pakistan. The genotypes were being cultivated for eight years in randomized complete block design (RCBD), and data was kept on recording during the months of high disease pressure. Data was collected after ten days interval using disease scoring scale developed by International Rice Research Institute (IRRI) during 1996. Simple linear regression models were used to determine the relationship of environmental factors with RBD severity. The variation in RBD severity due to environmental factors was determined using coefficient of determination (R2). In present study, the relationship of max temp, Rf, Rh and Ws with RBD severity was positive, significant and linear, however, the relationship of min temp with RBD severity was negative. Max temp 40-42°C, min temp 21-23°C, Rf 2-3mm, Rh 50-70% and Ws 9-11 Km/h were found to be most favourable environmental conditions for RBD severity. The current research disclosed the significant role of all five environmental factors in the spread of RBD. Thus, future predictive models could be established using these five environmental factors for more accurate prediction of this disease in rice belt of Punjab, Pakistan, to time the application of fungicides.
A Comprehensive Assessment of Verticillium Wilt of Potato: Present Status and Future Prospective
Authors: C Shreejana K , Poudel Amrit , Oli Dipiza , Ghimire Shirish , Angon Prodipto Bishnu , Islam Md. Shafiul
Published: September 2023

The fungal disease Verticillium wilt is a soil-borne pathogen that is caused by Verticillium dahliae. This disease affects a wide range of crops and can cause significant yield losses. Recent findings suggest that Verticillium wilt has been affecting potato crops in abundant domains around the global world, including in North America, parts of Europe, and Asia. In some cases, the disease has been observed in fields where it has not been previously reported, indicating that it has been spreading. Farmers and researchers are working to manage the disease through a variety of measures, including rotation of crops, the use of resistant varieties of potato developed from resistant strains, and the application of fungicides. However, the potency of these measures can vary depending on the ferocity of the disease and the local growing circumstances. Overall, the recent findings of Verticillium wilt in potato underscore the importance of continued monitoring and research to better understand the disease and develop effective management strategies. This review has highlighted the up-to-date information on Verticillium wilt and management strategies. The study also helps the scientific community understand this devastating plant disease by offering a thorough review of the situation.
Análisis comparativo de la interacción discursiva de dos ‘edutubers’ de matemáticas
Authors: Anzola-Gomez John , Rivera-Rogel Diana
Published: September 2023

Los nuevos entornos digitales han permitido la creación de contenidos multimediales que pueden llegar a una gran cantidad de usuarios. YouTube es utilizada por profesores que crean contenido educativo y es pertinente preguntarse por la interacción discursiva que los creadores establecen con sus usuarios. En esta investigación se comparan dos canales de YouTube dedicados a la enseñanza de matemáticas, Unicoos y Matemáticas profe Alex, para evaluar si hay diferencias significativas en cuanto a la interacción discursiva. La identificación de la interacción discursiva se hizo mediante el metadiscurso aplicando el modelo interpersonal. Se realizó un análisis de contenido cualitativo y se aplicó la prueba Chi-cuadrado. Los resultados muestran que existen diferencias significativas en cuanto a la interacción discursiva entre los dos edutubers. Estas diferencias se reflejan en la forma de interactuar, en el uso de preguntas, en la incorporación de marcas de aportes personales y marcas de conocimiento compartido. El uso de estrategias dialógicas no se hace con una finalidad pedagógica, aunque el contenido producido es educativo. Esta investigación es relevante porque muestra la necesidad de diseñar contenido educativo con intencionalidad pedagógica y dialógica.
aplicabilidad del neuromarketing en la publicidad del sector lujo. Situación actual, potencial de crecimiento y limitaciones
Authors: Cenizo Coral
Published: September 2023

La importancia del consumidor en la publicidad actual ha obligado a las marcas de lujo a adaptar sus anuncios para hacerlos más personalizados a fin de llegar de forma eficiente al público objetivo. Sin embargo, esta individualización exige un conocimiento de la audiencia que las técnicas actuales de investigación no satisfacen. Esto enlaza con el neuromarketing, una disciplina que ha suscitado en los últimos años atención por su potencial para proporcionar una comprensión profunda del comportamiento y las preferencias de los consumidores. Este artículo proporciona un análisis exhaustivo de la aplicabilidad del neuromarketing en el ámbito de la publicidad a fin de valorar su potencial uso en el sector del lujo. Mediante una revisión exhaustiva de la bibliografía existente, se definen las áreas de la publicidad en las que el neuromarketing puede aportar un valor diferencial, se especifican las técnicas que hasta la fecha han resultado más eficientes en el ámbito publicitario y se analizan las posibles limitaciones de aplicabilidad. Este estudio ofrece una valiosa perspectiva sobre el potencial del neuromarketing como herramienta para comprender el comportamiento del consumidor y mejorar la eficacia de la publicidad en sectores altamente competitivos como el del lujo.
Two Terms of Endearment: Incumbent-Party Performance in U.S. Presidential Elections
Authors: Kane John
Published: September 2023

Presidential elections are arguably the most consequential recurring political event in the United States. Understanding the factors that determine their outcomes, therefore, is of substantial importance. One proposed factor pertains to candidates’ incumbency status, yet its nature is complex and difficult to study with observational data. In particular, the individual-level mechanisms underlying incumbency effects remain surprisingly unclear. This Letter proposes many citizens generally believe that, ceteris paribus, presidents should be afforded two terms. Existence of such a norm implies that incumbency status possesses an inherent effect, operating independent of other mechanisms stemming from incumbency. A large, pre-registered survey experiment is employed to isolate incumbency status, finding evidence for a one-term advantage and clarifying the nature of the two-term disadvantage. The study thus uncovers a micro-foundational mechanism underlying incumbent-party performance in presidential elections. Finally, analyses of panel data explore which voters may be systematically inclined to vote based upon incumbency status.
Lagrangian motion magnification with double sparse optical flow decomposition
Authors: Flotho Philipp , Heiss Cosmas , Steidl Gabriele , Strauss Daniel J.
Published: September 2023

Microexpressions are fast and spatially small facial expressions that are difficult to detect. Therefore, motion magnification techniques, which aim at amplifying and hence revealing subtle motion in videos, appear useful for handling such expressions. There are basically two main approaches, namely, via Eulerian or Lagrangian techniques. While the first one magnifies motion implicitly by operating directly on image pixels, the Lagrangian approach uses optical flow (OF) techniques to extract and magnify pixel trajectories. In this study, we propose a novel approach for local Lagrangian motion magnification of facial micro-motions. Our contribution is 3-fold: first, we fine tune the recurrent all-pairs field transforms (RAFT) for OFs deep learning approach for faces by adding ground truth obtained from the variational dense inverse search (DIS) for the OF algorithm applied to the CASME II video set of facial micro expressions. This enables us to produce OFs of facial videos in an efficient and sufficiently accurate way. Second, since facial micro-motions are both local in space and time, we propose to approximate the OF field by sparse components both in space and time leading to a double sparse decomposition. Third, we use this decomposition to magnify micro-motions in specific areas of the face, where we introduce a new forward warping strategy using a triangular splitting of the image grid and barycentric interpolation of the RGB vectors at the corners of the transformed triangles. We demonstrate the feasibility of our approach by various examples.