bluuebunny/crossref_metadata_2025 huggingface dataset:
Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor
Authors: Zhang Zhiwei , Jiang Duqing , Yang Huan , He Zhou , Liu Xiangzhen , Qin Wenxia , Li Linfang , Wang Chao , Li Yang , Li He , Xu Hai , Jin Huajun , Qian Qijun
Published: June 2019

Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (meso3 CAR, also known as a membrane-proximal region) using a modified piggyBac transposon system. We reported that, compared with meso1 CAR T cells, meso3 CAR T cells express higher levels of CD107α upon activation and produce increased levels of interleukin-2, TNF-α, and IFN-γ against multiple MSLN-expressing cancer cells in vitro. In a real-time cell analyzer system and a three-dimensional spheroid cancer cell model, we also demonstrated that meso3 CAR T cells display an enhanced killing effect compared with that of meso1 CAR T cells. More importantly, in a gastric cancer NSG mice model, meso3 CAR T cells mediated stronger antitumor responses than meso1 CAR T cells did. We further identified that meso3 CAR T cells can effectively inhibit the growth of large ovarian tumors in vivo. Collectively, our study provides evidences that meso3 CAR T-cell therapy performs as a better immunotherapy than meso1 CAR T-cell therapy in treating MSLN-positive solid tumors.
Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion
Authors: Zaoui Kossay , Boudhraa Zied , Khalifé Paul , Carmona Euridice , Provencher Diane , Mes-Masson Anne-Marie
Published: June 2019

Ran is a nucleocytoplasmic shuttle protein that is involved in cell cycle regulation, nuclear-cytoplasmic transport, and cell transformation. Ran plays an important role in cancer cell survival and cancer progression. Here, we show that, in addition to the nucleocytoplasmic localization of Ran, this GTPase is specifically associated with the plasma membrane/ruffles of ovarian cancer cells. Ran depletion has a drastic effect on RhoA stability and inhibits RhoA localization to the plasma membrane/ruffles and RhoA activity. We further demonstrate that the DEDDDL domain of Ran is required for the interaction with serine 188 of RhoA, which prevents RhoA degradation by the proteasome pathway. Moreover, the knockdown of Ran leads to a reduction of ovarian cancer cell invasion by impairing RhoA signalling. Our findings provide advanced insights into the mode of action of the Ran-RhoA signalling axis and may represent a potential therapeutic avenue for drug development to prevent ovarian tumour metastasis.
Two and three-uniform states from irredundant orthogonal arrays
Authors: Pang Shan-Qi , Zhang Xiao , Lin Xiao , Zhang Qing-Juan
Published: June 2019

A pure quantum state of N subsystems, each with d levels, is said to be k-uniform if all of its reductions to k qudits are maximally mixed. Only the uniform states obtained from orthogonal arrays (OAs) are considered throughout this work. The Hamming distances of OAs are specially applied to the theory of quantum information. By using difference schemes and orthogonal partitions, we construct a series of infinite classes of irredundant orthogonal arrays (IrOAs), then answer the open questions of whether there exist 3-uniform states of N qubits and 2-uniform states of N qutrits, and whether 3-uniform states of qudits (d > 2) for high values of N can be explicitly constructed. In fact, we obtain 3-uniform states for an arbitrary number of N ≥ 8 qubits and 2-uniform states of N qutrits for every N ≥ 4. Additionally, we provide explicit constructions of the 3-uniform states of N ≥ 8 qutrits, N = 6 and N ≥ 8 ququarts and ququints, N ≥ 6 qudits having d levels for any prime power d > 6, and N = 8 and N ≥ 12 qudits having d levels for non-prime-power d ≥ 6. Moreover, we describe an explicit construction scheme for the 2-uniform states of qudits having d ≥ 4 levels. The proofs of existence of the 2-uniform states of N ≥ 6 qubits are simplified by using a class of OAs. Two special 3-uniform states are obtained from IrOA(32, 10, 2, 3) and IrOA(32, 11, 2, 3) using the interaction column property of OAs.
Human cell-derived tissue-engineered heart valve with integrated Valsalva sinuses: towards native-like transcatheter pulmonary valve replacements
Authors: Motta Sarah E. , Lintas Valentina , Fioretta Emanuela S. , Dijkman Petra E. , Putti Matilde , Caliskan Etem , Rodriguez Cetina Biefer Héctor , Lipiski Miriam , Sauer Mareike , Cesarovic Nikola , Hoerstrup Simon P. , Emmert Maximilian Y.
Published: June 2019

Transcatheter valve replacement indication is currently being extended to younger and lower-risk patients. However, transcatheter prostheses are still based on glutaraldehyde-fixed xenogeneic materials. Hence, they are prone to calcification and long-term structural degeneration, which are particularly accelerated in younger patients. Tissue-engineered heart valves based on decellularized in vitro grown tissue-engineered matrices (TEM) have been suggested as a valid alternative to currently used bioprostheses, showing good performance and remodeling capacity as transcatheter pulmonary valve replacement (TPVR) in sheep. Here, we first describe the in vitro development of human cell-derived TEM (hTEM) and their application as tissue-engineered sinus valves (hTESVs), endowed with Valsalva sinuses for TPVR. The hTEM and hTESVs were systematically characterized in vitro by histology, immunofluorescence, and biochemical analyses, before they were evaluated in a pulse duplicator system under physiological pulmonary pressure conditions. Thereafter, transapical delivery of hTESVs was tested for feasibility and safety in a translational sheep model, achieving good valve performance and early cellular infiltration. This study demonstrates the principal feasibility of clinically relevant hTEM to manufacture hTESVs for TPVR.
A Nonlinear Rate Microsensor utilising Internal Resonance
Authors: Sarrafan Atabak , Azimi Soheil , Golnaraghi Farid , Bahreyni Behraad
Published: June 2019

Micro- and nano-resonators have been studied extensively both for the scientific viewpoint to understand basic interactions at small scales as well as for applied research to build sensors and mechanical signal processors. Majority of the resonant microsystems, particularly those manufactured at a large scale, have employed simple mechanical structures with one dominant resonant mode, such as in timing resonators, or linearly coupled resonant modes, as in vibratory gyroscopes. There is an increasing interest in the development of models and methods to better understand the nonlinear interactions at micro- and nano-scales and also to potentially improve the performance of the existing devices in the market beyond limits permissible by the linear effects. Internal resonance is a phenomenon that allows for nonlinear coupling and energy transfer between different vibration modes of a properly designed system. Herein, for the first time, we describe and experimentally demonstrate the potential for employing internal resonance for detection of angular rate signals, where the Coriolis effect modifies the energy coupling between the distinct drive and sense vibration modes. In doing so, in addition to providing a robust method of exciting the desired mode, the proposed approach further alleviates the mode-matching requirements and reduces instabilities due to the cross-coupling between the modes in current linear vibratory gyroscopes.
Pulmonary MALT Lymphoma has variable features on CT
Authors: Deng Wen , Wan Ying , Yu Jian-qun
Published: June 2019

Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is the most common primary pulmonary lymphoma. There are limited studies on imaging features of pulmonary MALT lymphoma. We present the computed tomography (CT) manifestations of pulmonary MALT lymphoma and the correlation between CT manifestations and clinical characteristics. Patients (n = 53) with histologically confirmed pulmonary MALT lymphoma who underwent chest CT scanning were retrospectively analyzed. Evaluated findings included distribution of pulmonary lesions, morphological pattern of appearance, contrast enhancement features, size, presence of thoracic lymphadenopathy, and secondary associated features. Pulmonary MALT lymphoma was observed in multiple (79%) and bilateral (66%) disease with random distribution (≥70%) of pulmonary lesions. The most frequent morphological pattern was consolidation (n = 33, 62%), followed by nodule (n = 23, 43%) and mass (n = 11, 21%). Common associated features were air bronchograms and bronchiectasis, especially cystic bronchiectasis and angiogram sign. Asymptomatic patients had less consolidation and bronchiectasis than did symptomatic patients. Cystic bronchiectasis was only observed in the symptomatic group. In conclusion, pulmonary MALT lymphoma manifests as diverse patterns on CT scans. Consolidation combined with cystic bronchiectasis was a characteristic late sign, which may assist in differential diagnosis. High-resolution CT images and multiplanar reconstruction techniques are helpful for accurately determining imaging manifestations.
Flow Density in Optical Coherence Tomography Angiography is Useful for Retinopathy Diagnosis in Diabetic Patients
Authors: Kaizu Yoshihiro , Nakao Shintaro , Arima Mitsuru , Hayami Takehito , Wada Iori , Yamaguchi Muneo , Sekiryu Haruka , Ishikawa Keijiro , Ikeda Yasuhiro , Sonoda Koh-Hei
Published: June 2019

Our study evaluated the diagnostic capability of flow density (FD) in OCT angiography (OCTA) for diabetic retinopathy (DR) detection in diabetic patients. We studied 93 eyes of 68 diabetic patients who underwent OCTA (36 and 57 eyes without and with DR, respectively). Retinal capillary FD of a 2.6 × 2.6 mm2 area and four divided areas at the superficial (SCP) and deep capillary plexus (DCP) were measured. Predictions were evaluated using the area under the receiver operating characteristic curve (AUC). The diagnostic capabilities of the FDs in discriminating between eyes without DR and eyes with total or early DR were compared. Furthermore, predictions with foveal avascular zone (FAZ) area, hemoglobin A1c (HbA1c), and DM duration were also compared with FD. Prediction using FD AUC in the temporal side in the DCP (0.83) was the highest and significantly better than all other AUCs examined (P < 0.05), including discriminating between eyes without DR and with early DR (P < 0.01). Prediction using this particular AUC was also significantly better than that by FAZ area and HbA1c (P < 0.001 and <0.001, respectively). Area-divided FD in OCTA may be valuable for diagnosing retinopathy in diabetic patients.
Recent advances in metal sulfides: from controlled fabrication to electrocatalytic, photocatalytic and photoelectrochemical water splitting and beyond
Authors: Chandrasekaran Sundaram , Yao Lei , Deng Libo , Bowen Chris , Zhang Yan , Chen Sanming , Lin Zhiqun , Peng Feng , Zhang Peixin
Published: June 2019

This review describes an in-depth overview and knowledge on the variety of synthetic strategies for forming metal sulfides and their potential use to achieve effective hydrogen generation and beyond.
Robust and highly specific fluorescence sensing of Salmonella typhimurium based on dual-functional phi29 DNA polymerase-mediated isothermal circular strand displacement polymerization
Authors: Li Shasha , Liu Su , Xu Yicheng , Zhang Rufeng , Zhao Yihan , Qu Xiaonan , Wang Yu , Huang Jiadong , Yu Jinghua
Published: June 2019

A simple and robust fluorescence sensing strategy has been developed for the detection of pathogenic bacteria by the combination of the dual functionality of phi29 DNA polymerase with isothermal circular strand displacement polymerization (ICSDP).
Photoreaction-driven two-dimensional periodic polyrotaxane-type supramolecular nanoarchitecture
Authors: Zhang Cai-Cai , Zhang Ying-Ming , Zhang Zhi-Yuan , Wu Xuan , Yu Qilin , Liu Yu
Published: June 2019

A stable 2D supramolecular assembly was constructed with photoreaction-driven transformation from polypseudorotaxane to polyrotaxane, which could capture C60 in water and present excellent DNA cleavage ability and photodynamic therapy effect.
Effect of calcination conditions on the performance of Ni/MgO–Al2O3 catalysts in the steam reforming of biomass fast pyrolysis volatiles
Authors: Santamaria Laura , Lopez Gartzen , Arregi Aitor , Amutio Maider , Artetxe Maite , Bilbao Javier , Olazar Martin
Published: June 2019

A study was carried out to understand the influence of calcination conditions of a Ni/MgO–Al2O3 catalyst on its performance and stability in the reforming of biomass fast pyrolysis volatiles.
Molecular survey ofLegionellaandNaegleria fowleriin private well water and premise plumbing following the 2016 Louisiana flood
Authors: Dai Dongjuan , Rhoads William J. , Katner Adrienne , Strom Laurel , Edwards Marc A. , Pruden Amy , Pieper Kelsey J.
Published: June 2019

This is the first community-wide survey of opportunistic pathogens in private wells and premise plumbing following a flooding event.
A novel confocal XRF-Raman spectrometer and FPM model for analysis of solid objects and liquid substances
Authors: Szalóki I. , Pintér T. , Szalóki I. , Radócz G. , Gerényi A.
Published: June 2019

A new table-top combined spectrometer was designed and constructed consisting of X-ray fluorescence and Raman spectrometers for spot-analysis of elementary and chemical composition of solid and liquid substances for industrial analytical applications.
Template-directed self-organization of colloidal PbTe nanocrystals into pillars, conformal coatings, and self-supported membranes
Authors: Piotrowski Marek , Borme Jérôme , Carbó-Argibay Enrique , Sharma Deepanjan , Nicoara Nicoleta , Sadewasser Sascha , Petrovykh Dmitri Y. , Rodríguez-Abreu Carlos , Kolen'ko Yury V.
Published: June 2019

We produce morphologies relevant for integration with miniaturized devices—microscale pillars, conformal coatings, and self-supported membranes—via template-directed self-organization of PbTe colloidal nanocrystals.
A “center-determination” phenomenon of C13H27CO-Gly-Ala-Ala lipotripetides: relationship between the molecular chirality and handedness of organic self-assemblies
Authors: Guo Kexiao , Zhang Lianglin , Lin Shuwei , Li Yi , Li Baozong , Yang Yonggang
Published: June 2019

The chirality of the central alanine residue dominates the handedness of molecular packing and that of organic self-assemblies.
Correction: Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery
Authors: Rostamizadeh Kobra , Manafi Mostafa , Nosrati Hamed , Manjili Hamidreza Kheiri , Danafar Hossein
Published: June 2019

Correction for ‘Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery’ by Kobra Rostamizadeh et al., New J. Chem., 2018, 42, 5937–5945.
Vapor/liquid polymerization of ultraporous transparent and capacitive polypyrrole nanonets
Authors: Santino Luciano M. , Diao Yifan , Yang Haoru , Lu Yang , Wang Hongmin , Hwang Erica , D'Arcy Julio M.
Published: June 2019

Polypyrrole nanonets exhibiting a high specific capacitance of 518 F g−1 are synthesized via vapor–liquid interfacial polymerization and engineered into electrochemical capacitors.
Aligned carbon nanotube morphogenesis predicts physical properties of their polymer nanocomposites
Authors: Natarajan Bharath , Stein Itai Y. , Lachman Noa , Yamamoto Namiko , Jacobs Douglas S. , Sharma Renu , Liddle J. Alexander , Wardle Brian L.
Published: June 2019

Tomography derived nanoscale 3D morphological information is combined with modeling and simulation to explain anisotropy and scaling of experimental mechanical, thermal, and electrical properties of aligned carbon nanotube polymer composites.
Design and understanding of core/branch-structured VS2 nanosheets@CNTs as high-performance anode materials for lithium-ion batteries
Authors: Li Xing , Fu Jiatian , Sun Yuping , Sun Mei , Cheng Shaobo , Chen Kaijian , Yang Xigui , Lou Qing , Xu Tingting , Shang Yuanyuan , Xu Junmin , Chen Qing , Shan Chongxin
Published: June 2019

Electrochemical properties of core/branch-structured VS2 nanosheets@CNTs and the in situ investigation of the corresponding dynamic structural evolutions.
Graphene foam-embedded epoxy composites with significant thermal conductivity enhancement
Authors: Liu Zhiduo , Chen Yapeng , Li Yifan , Dai Wen , Yan Qingwei , Alam Fakhr E. , Du Shiyu , Wang Zhongwei , Nishimura Kazuhito , Jiang Nan , Lin Cheng-Te , Yu Jinhong
Published: June 2019

A facile, low-cost and scalable method is developed to construct three-dimensional thermal transport channels like highways in polymer composites.
A novel gold-nanocluster-based fluorescent sensor for detection of sodium 2-mercaptoethanesulfonate
Authors: Su Jiaxing , Feng Chenchen , Wu Yuan , Liang Jiangong
Published: June 2019

Schematics illustrating the MES-induced fluorescence enhancement of His-Au NCs for MES quantification because of the surface ligand exchange between His and MES.
A new way to improve the light-fastness of azo reactive dyes through the introduction of benzene sulfonamide derivatives into the triazine ring
Authors: Wei Xiong , Wei Ma , Shufen Zhang
Published: June 2019

Herein, a new kind of hetero-bifunctional reactive dyes with high light-fastness was designed and synthesized by introducing benzene sulfonamide and its derivatives into the triazine ring.
Controllable synthesis of three-dimensional nitrogen-doped hierarchical porous carbon and its application in the detection of lead
Authors: Dai Runying , Ma Xue , Xu Quan , Lu Limin
Published: June 2019

In this study, gelatin-based microcapsules were first proposed as a carbon source for the synthesis of nitrogen-doped hierarchical porous carbon (N-HPC) via a facile one-pot high-temperature treatment.
Investigation of the agglomeration reduction mechanism of the aluminized HTPB propellant containing ferric perfluorooctanoate [Fe(PFO)3]
Authors: Zhen Fei , Zhou Xuyuan , Zou Meishuai , Meng Lingchao , Yang Rongjie , Wang Liqiong , Huang Fenglei , Li Jianmin
Published: June 2019

In this study, ferric perfluorooctanoate [Fe(PFO)3] was used in the aluminized HTPB propellant to reduce Al agglomeration during solid propellant combustion, and the agglomeration reduction mechanism was experimentally demonstrated.
A novel synthesis of silver nanowires by using 6-chlorohexylzinc bromide as an additive for low haze transparent conductive films
Authors: Yuan Ximin , Yang Hongwei , Li Yuxiu , Chao Yunxiu , Li Yao , Chen Li , Chen Jialin
Published: June 2019

Silver nanowires with a diameter of ∼20 nm and length of 40 μm were prepared by using 6-chlorohexylzinc bromide as an additive.
Effect of oxygen on power frequency breakdown voltage and decomposition characteristics of the C5F10O/N2/O2 gas mixture
Authors: Zhang Yue , Zhang Xiaoxing , Li Yi , Li Yalong , Chen Qi , Zhang Guozhi , Xiao Song , Tang Ju
Published: June 2019

C5F10O gas mixture is a SF6 potential substitute with high insulation strength and is a new type of environmentally friendly insulating gas. By adding oxygen to C5F10O gas mixture, insulation strength can be improved and carbon deposition can be suppressed.
The mutual influence between corrosion and the surrounding soil microbial communities of buried petroleum pipelines
Authors: Su Hong , Mi Shuofu , Peng Xiaowei , Han Yejun
Published: June 2019

Buried petroleum pipeline corrosion and leaks cause inevitable changes in the microbial communities of the surrounding soils.
Pressure-induced phase transition of La2Zr2O7 and La0.5Gd1.5Zr2O7 pyrochlore
Authors: Niu Jingjing , Wu Xiang , Zhang Haibin , Qin Shan
Published: June 2019

In situ high-pressure experiments on La2Zr2O7 and La0.5Gd1.5Zr2O7 have been carried out at up to approximately 40 GPa using synchrotron X-ray diffraction and Raman spectroscopy combined with a diamond anvil cell technique.
Colour-tunable ultralong organic phosphorescence upon temperature stimulus
Authors: Niu Zuoji , Ma Chaoqun , Ye Wenpeng , Wang He , Jia Wenyong , Shi Huixian , Shi Huifang , An Zhongfu , Huang Wei
Published: June 2019

A new class of single-component molecular crystal with colour-tunable ultralong organic phosphorescence (UOP) was designed and synthesized through alkyl chain engineering.
Correction: Surface core–shell magnetic polymer modified graphene oxide-based material for 2,4,6-trichlorophenol removal
Authors: Chen Mei-Lan , Min Jian-Qing , Pan Sheng-Dong , Jin Mi-Cong
Published: June 2019

Correction for ‘Surface core–shell magnetic polymer modified graphene oxide-based material for 2,4,6-trichlorophenol removal’ by Mei-Lan Chen et al., RSC Adv., 2014, 4, 63494–63501.
A photocapacitor with high working voltage and energy density
Authors: Gao Kun , Ti Dan , Zhang Zhipan
Published: June 2019

The carbon-supported graphene/PEDOT common electrode enables the fabrication of photocapacitors with high voltage and energy density.
pH-Switchable IFT variations and emulsions based on the dynamic noncovalent surfactant/salt assembly at the water/oil interface
Authors: Jia Han , Leng Xu , Lian Peng , Han Yugui , Wang Qiuxia , Wang Shaoyan , Sun Tunan , Liang Yipu , Huang Pan , Lv Kaihe
Published: June 2019

Additional HCl can facilely control the dynamic noncovalent interaction between anionic surfactant sodium dodecyl benzene sulfonate (SDBS) and additional organic matter, 4,4′-oxydianiline (ODA), at the water/oil interface.
Control of growth factor signalling by MACPF proteins
Authors: Bakopoulos Daniel , Whisstock James C. , Johnson Travis K.
Published: June 2019

Members of the membrane attack complex/perforin-like (MACPF) protein superfamily have long captured interest because of their unique ability to assemble into large oligomeric pores on the surfaces of cells. The best characterised of these act in vertebrate immunity where they function to deliver pro-apoptotic factors or induce the cytolysis and death of targeted cells. Less appreciated, however, is that rather than causing cell death, MACPF proteins have also evolved to control cellular signalling pathways and influence developmental programmes such as pattern formation and neurogenesis. Torso-like (Tsl) from the fruit fly Drosophila, for example, functions to localise the activity of a growth factor for patterning its embryonic termini. It remains unclear whether these developmental proteins employ an attenuated form of the classical MACPF lytic pore, or if they have evolved to function via alternative mechanisms of action. In this minireview, we examine the evidence that links pore-forming MACPF proteins to the control of growth factor and cytokine signalling. We will then attempt to reconcile how the MACPF domain may have been repurposed during evolution for developmental events rather than cell killing.
TET enzymes, DNA demethylation and pluripotency
Authors: Ross Samuel E. , Bogdanovic Ozren
Published: June 2019

Ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3) actively cause demethylation of 5-methylcytosine (5mC) and produce and safeguard hypomethylation at key regulatory regions across the genome. This 5mC erasure is particularly important in pluripotent embryonic stem cells (ESCs) as they need to maintain self-renewal capabilities while retaining the potential to generate different cell types with diverse 5mC patterns. In this review, we discuss the multiple roles of TET proteins in mouse ESCs, and other vertebrate model systems, with a particular focus on TET functions in pluripotency, differentiation, and developmental DNA methylome reprogramming. Furthermore, we elaborate on the recently described non-catalytic roles of TET proteins in diverse biological contexts. Overall, TET proteins are multifunctional regulators that through both their catalytic and non-catalytic roles carry out myriad functions linked to early developmental processes.
Re-exploring Molecular Complexity with ALMA (ReMoCA): interstellar detection of urea
Authors: Belloche A. , Garrod R. T. , Müller H. S. P. , Menten K. M. , Medvedev I. , Thomas J. , Kisiel Z.
Published: June 2019

Context. Urea, NH2C(O)NH2, is a molecule of great importance in organic chemistry and biology. Two searches for urea in the interstellar medium have been reported in the past, but neither were conclusive.

Aims. We want to take advantage of the increased sensitivity and angular resolution provided by the Atacama Large Millimeter/submillimeter Array (ALMA) to search for urea toward the hot molecular cores embedded in the high-mass-star-forming region Sgr B2(N).

Methods. We used the new spectral line survey named ReMoCA (Re-exploring Molecular Complexity with ALMA) that was performed toward Sgr B2(N) with ALMA in its observing cycle 4 between 84 and 114 GHz. The spectra were analyzed under the local thermodynamic equilibrium approximation. We constructed a full synthetic spectrum that includes all the molecules identified so far. We used new spectroscopic predictions for urea in its vibrational ground state and first vibrationally excited state to search for this complex organic molecule in the ReMoCA data set. We employed the gas-grain chemical kinetics model MAGICKAL to interpret the astronomical observations.

Results. We report the secure detection of urea toward the hot core Sgr B2(N1) at a position called N1S slightly offset from the continuum peak, which avoids obscuration by the dust. The identification of urea relies on nine clearly detected transitions. We derive a column density of 2.7 × 1016 cm−2 for urea, two orders of magnitude lower than the column density of formamide, and one order of magnitude below that of methyl isocyanate, acetamide, and N-methylformamide. The latter molecule is reliably identified toward N1S with 60 clearly detected lines, confirming an earlier claim of its tentative interstellar detection. We report the first interstellar detections of NH2CH18O and 15NH2CHO. We also report the nondetection of urea toward the secondary hot core Sgr B2(N2) with an abundance relative to the other four species at least one order of magnitude lower than toward the main hot core. Our chemical model roughly reproduces the relative abundances of formamide, methyl isocyanate, acetamide, and N-methylformamide, but it overproduces urea by at least one order of magnitude.

Conclusions. Urea is clearly detected in one of the hot cores. Comparing the full chemical composition of Sgr B2(N1S) and Sgr B2(N2) may help understand why urea is at least one order of magnitude less abundant in the latter source.
Evaluation of the wind power potential in the European nearshore of the Mediterranean Sea
Authors: Rusu Eugen , Rusu Liliana
Published: June 2019

In the last years, the offshore wind sector has been constantly growing in Europe, coming also with a very competitive production price. The objective of this paper is to evaluate the wind power potential in the European coastal environment of the Mediterranean Sea, an area with a high population density. Furthermore, a high energy demand exists here and the potential of the renewable energy resources needs to be assessed for further exploitation. The analysis was performed considering some reference locations. The climate change impact on the wind energy resource is also investigated. Various comparisons between historical data and future climate projections simulated by a Regional Climate Model under RCP4.5 scenario are made. The results obtained show that in various locations, especially in Golf of Lion and the Aegean Sea, there are appropriate conditions for offshore wind exploitations.
The Impact of Variable Thermal Conductivity of Insulation Materials on the Building Energy Performance in Hot Climate
Authors: Khoukhi Maatouk , Hassan Ahmed , Abdelbaqi Shaimaa
Published: June 2019

This paper illustrates the impact of embedding an insulation layer of variable thermal conductivity in a typical building wall on the cooling effect and energy performance. The evaluation was performed by applying a conjugate heat transfer model, which was tested in extremely hot conditions of Al Ain (UAE). The thermal performance of a building incorporating insulation layers of variable thermal conductivity (k-value) was compared to a non-variable thermal conductivity system by quantifying the additional heat transferred due to the k-relationship with time. The results show that, when the k-value is a function of operating temperature, its effects on the temperature profile through the wall assembly during daytime is significant compared with that obtained when a constant k-value for the polystyrene (EPS) insulation is adopted. A similar trend in the evolution of temperatures during the day and across the wall section was observed when EPS material with different moisture content was evaluated. For the polyurethane insulation, the inner surface temperature reached 44 °C when constant k-value was adopted, increasing to 48.5 °C when the k-value was allowed to vary under the same ambient conditions.
Analysis of Wave Energy Conversion with Dynamic Systems Theory
Authors: Ciortan Sorin , Rusu Eugen
Published: June 2019

In wave energy conversion one of the most important steps is building scenarios about long term efficiency, taking into account that several factors are involved. Based on the assumption that actually the weather conditions show important modifications year by year, analyses of wave power evolution during the exploitation time range must rely on both prediction models and on several options for the conversion device. From this point of view, the wave energy conversion process can be considered a dynamic system. The dynamic system theory based methodology approach systems behaviour through relationships between systems components. Comparing to usual scientific approaches, which try to decompose the analyzed system, this methodology offers a view of entire system behaviour The paper presents a method for building scenarios of wave energy conversion, in the nearshore of the Black Sea, based on a model which includes also forecasts of the weather influence.
New results and perspectives in neutrino physics
Authors: Kudenko Yury
Published: June 2019

A brief review of new results and perspectives in neutrino physics is presented. An emphasis on a search for CP violation in neutrino oscillations and a search for sterile neutrinos is given. Status of measurement of the direct neutrino mass measurement and searches for neutrinoless double beta decay are also discussed.
The Super C-τ Factory particle identification system options
Authors: Barnyakov A.Yu. , Barnyakov M.Yu. , Boborovnikov V.S , Buzykaev A.R. , Bykov A.V. , Danilyuk A.F. , Katcin A.A. , Kononov S.A. , Korda D.V. , Kravchenko E.A. , Kuyanov I.A. , Onuchin A.P. , Ovtin I.V. , Plekhov I.M. , Podgornov N.A. , Razuvaev G.P. , Todyshev K.Yu. , Vorobiev V.S.
Published: June 2019

The Super C-τ (SCT) Factory at Novosibirsk is a project of new colliding beam experiment proposed in Budker Institute of Nuclear Physics. Electron-positron collider based on Crab-Waist technique for operation energy range 2–5 GeV in center of mass is suggested. The luminosity up to 1035cm−1s−1 (in 100 times higher than in operated today experiments in this energy region) is expected. To perform broad experimental program of the project successfully the excellent particle identification (PID) system is needed. A number of options are under consideration. Three of them are described in the paper: Focusing Aerogel RICH (FARICH) detector, threshold Cherenkov counters based on ASHIPH (Aerogel SHifter PHotomultiplier) technique with 6000 litres of aerogel of two refractive indexes and time-of-flight counters with TOP (Time of Propagation) approach with time resolution better than 30 ps. Comparison of PID capabilities with help of parametric simulation is given.
Charmonium studies at Belle
Authors: Chilikin Kirill
Published: June 2019

A review of recent charmonium studies at Belle is presented.
Review of bottomonium studies at Belle
Authors: Mizuk Roman
Published: June 2019

We review recent bottomonium studies at Belle. The results include the new measurement of the ηb(1S ) mass, the observation of the γ(4S ) → γ (1S )η’ transition, and the observation of the e+e−→ χbJ (1P)π+π−π0 process in the Υ(11020) region.
Semileptonic D0 and D+ decays as a probe of the a0(980) nature
Authors: Ahasov Nikolay N. , Kiselev Alexey V.
Published: June 2019

The $ {D^ + } \to d\bar d{e^ + }v \to a_0^0\left( {980} \right){e^ + }\nu {\rm{ }} \to {\pi ^0}\eta {e^ + }\nu $ and $ {D^0} \to d\bar u{e^ + }\nu {\rm{ }} \to a_0^ - \left( {980} \right){e^ + }\nu {\rm{ }} \to {\pi ^ - }\eta {e^ + }\nu $ decays (with the charge conjugated ones) are the direct probe of the constituent two-quark components in the $ a_0^ \pm (980) $ and $ a_0^0(980) $ wave functions. Recent BESIII experiment is the first step in experimental study of these decays. We suggest adequate formulas for the data analysis and present a variant of ηπ invariant mass distribution when a0(980) has no constituent two-quark component at all.
Meson production in e+e- annihilation and tau lepton decays within extended NJL model
Authors: Arbuzov Andrej , Pivovarov Aleksey , Nurlan Kanat , Volkov Mikhail
Published: June 2019

The Nambu–Jona-Lasinio model is applied to describe processes of electron-positron annihilation into mesons at center-of-mass energies below 2GeV and hadronic decays of tau leptons. Contributions of intermediate scalar, vector, and axial-vector mesons in the ground and first radial excited states are taken into account. Comparisons with existing experimental data are performed. Theoretical predictions for several(not yet measured)processes are presented.
Recent results from CMD-3
Authors: Ignatov F. V. , Akhmetshin R. R. , Amirkhanov A. N. , Anisenkov A. V. , Aulchenko V. M. , Banzarov V. Sh. , Bashtovoy N. S. , Berkaev D. E. , Bondar A. E. , Bragin A. V. , Eidelman S. I. , Epifanov D. A. , Epshteyn L. B. , Erofeev A. L. , Fedotovich G. V. , Gayazov S. E. , Grebenuk A. A. , Gribanov S. S. , Grigoriev D. N. , Ivanov V. L. , Karpov S. V. , Kazanin V. F. , Koop I. A. , Kirpotin A. N. , Korobov A. A. , Kozyrev A. N. , Kozyrev E. A. , Krokovny P. P. , Kuzmenko A. E. , Kuzmin A. S. , Logashenko I. B. , Lukin P. A. , Mikhailov K. Yu. , Okhapkin V. S. , Pestov Yu. N. , Popov A. S. , Razuvaev G. P. , Rogovsky Yu. A. , Ruban A. A. , Ryskulov N. M. , Ryzhenenkov A. E. , Semenov A. V. , Shatunov Yu. M. , Shatunov P. Yu. , Shebalin V. E. , Shemyakin D. N. , Shwartz B. A. , Shwartz D. B. , Sibidanov A. L. , Solodov E. P. , Titov V. M. , Talyshev A. A. , Vorobiov A. I. , Zemlyansky I. M. , Yudin Yu. V.
Published: June 2019

Regular data taking with the CMD-3 at the electron-positron collider VEPP-2000 is under way since 2010. The collected data sample corresponds to about 200 inverse picobarns of integrated luminosity per detector in the energy range from 0.32 up to 2 GeV, with a goal to collect about 1 fb−1 during next five years. Some of the recent results from the CMD-3 detector are discussed.
Muon-electron scattering at next-to-leading order accuracy
Authors: Carloni Calame Carlo M. , Chiesa Mauro , Montagna Guido , Nicrosini Oreste , Piccinini Fulvio
Published: June 2019

The next-to-leading order electro-weak radiative corrections to the µ±e- → µ±e- process are reviewed and their relevance is discussed for the MUonE experiment, proposed at CERN. The aim of MUonE is the high precision measurement of the QED running coupling constant in the space-like region, from which the full hadronic contribution can be extracted and used to provide a new and independent determination of the leading-order hadronic correction to the muon g − 2. In this context, the required accuracy demands that radiative corrections are accounted for at the highest level of precision and implemented into a Monte Carlo event generator for data analysis. The first step towards the final goal of theoretical precision, which will require the full set of NNLO corrections and resummation of higher orders, is the inclusion of NLO electro-weak corrections.
The Muon g − 2 experiment at Fermilab
Authors: Keshavarzi Alexander
Published: June 2019

The current ~ 3.5σ discrepancy between the experimental measurement and theoretical prediction of the muon magnetic anomaly, aµ, stands as a potential indication of the existence of new physics. The Muon g − 2 experiment at Fermilab is set to measure aµ with a four-fold improvement in the uncertainty with respect to previous experiment, with an aim to determine whether the g − 2 discrepancy is well established. The experiment recently completed its first physics run and a summer programme of essential upgrades, before continuing on with its experimental programme. The Run-1 data alone are expected to yield a statistical uncertainty of 350 ppb and the publication of the first result is expected in late-2019.
New Physics Beryond the SM at BESIII
Authors: Zhao Minggang
Published: June 2019

Numerous astrophysical observations strongly suggest the existence of Dark Matter, which provides a hint of dark sector physics. There could exist many dark candidates predicted by theories BSM, such as dark photons and invisible things, that communicate with the Standard Model sector. The masses and decay modes of these particles are expected to be accessible at the BESIII experiment which is the only currently running tau-charm factory with the largest threshold charm samples and some other unique datasets. We have recently performed searches of dark photons and invisible things in several decay modes. Besides, FCNC processes, BNV/LNV processes are also investigated. This talk will summarize the recent results at BESIII on these searches for new physics BSM.
Open Charm Physics at BESIII
Authors: Weidenkaﬀ Peter
Published: June 2019

The study of mesons and baryons containing at least one c quark is denoted as open charm physics. BESIII has collected large data samples at charm related thresholds which provide unique opportunities to study charm decays. BESIII has published many results in the past years. Among those we present the measurement of the CKM matrix elements |Vcd(s)|2 and the form factors fD(s) using the (semi-)leptonic decays Ds → µ+ νµ and D0 → K− µ+ νµ, a test for lepton flavour violation in the process D → Kπe+e+ and the study of intermediate states in the decays D → ππe+ν and $ {{\rm{D}}^{\rm{ + }}} \to {\rm{K}}_{\rm{S}}^0{\pi ^ - }{\pi ^ - }{\pi ^ + } $.
Potential contribution of selected metallic restorative dentistry materials to X-ray fluorescence
Authors: Andrade E.R. , Oliveira A.L.N. , Funcke L.N. , Souza L.H.F.F. , Healy M.J.F. , Vital H.C.
Published: June 2019

Recent advances have led to the use of new materials in dental restoration which is an area of rapid growth. Applications include improving oral aesthetics and essential rehabilitation, whilst procedures range from the recovery of partial elements (inlays) to fitting dental implants. Ceramics, polymers and metallic materials have all been successfully employed in dental applications and benefit from new cost efficient manufacturing techniques. The application of radiographic techniques in dentistry and other medicine is also increasing, and the combination of new materials and radiation can lead to an elevated health risk. X-rays can interact with metallic materials producing X-ray fluorescence, which can increase the radiation dose in proximity to restorative material and increase the risk of live biological tissue becoming cancerous. The issue demands consideration so that the biological risks associated with such procedures are kept as low as possible. Comparisons of doses calculated for several materials have provided evidence that the Ti cp and NiCrTi alloys present less contribution to the increase of dose in surrounding soft tissue and the potential deleterious biological effects. On the other hand, Amalgam appears to be the most deleterious alloy.
Long-Term Treatment with Calcitriol in Postsurgical Hypoparathyroidism Leads to Renal Function Decline
Authors: Coudenys Elien , Van Meerhaeghe Tess , Unuane David , Buyl Ronald , Bravenboer Bert
Published: June 2019

Hypoparathyroidism is a rare endocrine disease with insufficient parathyroid hormone levels. Replacing the missing hormone is not yet a standard therapy. The objective of this retrospective cohort study was to evaluate if the usual therapy regimens of postsurgical hypoparathyroidism with calcitriol have a negative effect on renal function. We performed a chart analysis of patients who were seen in a tertiary care hospital in Brussels, Belgium. A total of 101 subjects were identified as patients with permanent post-surgical hypoparathyroidism, based on the hospital records of patients who underwent a total thyroidectomy between 1996 and 2016, while still being treated with calcitriol. Patients with pre-existing renal insufficiency and/or active malignancy were excluded. The cohort was predominantly female of Caucasian origin. Renal function was evaluated before and after surgery (with a maximum follow-up of 12 years), using the CKD-EPI equation. A multivariate linear regression model was used to correlate renal function decline with the duration of calcitriol therapy, while correcting for the mean calcium phosphate product and age. We found a statistically significant (p=0.027) relationship between the duration of calcitriol treatment and renal function decline at a rate of 1.06 ml/min/1.73 m2 per year of calcitriol therapy. Our study, although being retrospective, is the first one to demonstrate a relationship between the cumulative use of calcitriol therapy and renal function decline.
Pseudopancreatic Cyst Extending into the Mediastinum in a 7-Year-Old Child
Authors: Kotb Mostafa , Oshiba Ahmed , Ashour Khaled
Published: June 2019

Mediastinal pseudopancreatic cyst (MPP) is the extension of a pancreatic pseudocyst through esophageal or aortic hiatus into the posterior mediastinum. It can produce a range of manifestations caused by compression by the cyst, for instance, odynophagia, dysphagia, pericardial, or pleural effusion. Here we report a case of MPP in a 7-year-old child who was presented with repeated chest infections and left pleural effusion. It was successfully drained by cystogastrostomy.
Editorial: Erfolgreiche Wege zur Prozessoptimierung
Authors: Otten Hubert
Published: June 2019

Alle reden von Prozessoptimierung. Und Digitalisierung. Und Vernetzung. Das Kürzel 4.0 ist branchenübergreifend in aller Munde und das Arbeiten 4.0 mag gar manchen ängstigen. Doch wie sieht es in der Praxis aus? Es werden Dutzende von Anglizismen verwendet, die bei näherem Hinsehen oft noch nicht eindeutig definiert sind (was aber für deutsche Bezeichnungen in diesem Kontext gleichermaßen gilt). Zudem wird das Potenzial innovativer, leistungsfähiger Technologien momentan aus verschiedenen Gründen nur rudimentär ausgeschöpft. Wir wissen, dass Digitalisierung und Vernetzung der Prozessoptimierung einen enormen zusätzlichen Schub geben können und damit die Leistungsfähigkeit eines Prozesses wesentlich gesteigert werden kann. Thorsten Dirks (2015 bis 2017 Präsident des Branchenverbandes Bitkom und heute Vorstand der Deutschen Lufthansa AG) sagte allerdings schon vor Jahren der Süddeutschen Zeitung: „Wenn Sie einen Scheißprozess digitalisieren, dann haben Sie einen scheiß digitalen Prozess.“
Ausbildung: Der Perfekte Einkäufer - von der Illusion zur Kompetenz
Authors: Mehner Manuela
Published: June 2019

Die Diskrepanz zwischen den Anforderungen an einen Klinikeinkäufer und der Ausbildung, die ihnen in der Regel zu Teil wird, ist häufig enorm. Der perfekte Einkäufer muss dennoch keine Illusion bleiben.
E-Rechnung im Öffentlichen Sektor: Standardisierter Datenaustausch macht Behörden Schneller
Authors: Hauschild Matthias
Published: June 2019

In einer digitalen Geschäftswelt ermöglicht ein standardisierter elektronischer Datenaustausch grundsätzlich eine schnelle und effiziente (Weiter-)Verarbeitung der benötigten Daten. Dies trifft auch auf den Austausch elektronischer Rechnungen zu. Rechnungssteller und Rechnungsempfänger profitieren von einer Automatisierung der damit verbundenen Verwaltungsprozesse.
Thermodynamic and transport properties of meteor melt constituents from ab initio simulations: MgSiO3, SiO2, and MgO
Authors: Haskins Justin B. , Stern Eric C. , Bauschlicher Charles W. , Lawson John W.
Published: June 2019

Recent experiments have suggested that melt flow plays a critical role in the ablation of meteoroids during atmospheric entry. Thus, modeling ablation requires knowledge of the melt properties of meteoritic constituents. These properties, however, are poorly understood and difficult to obtain with experimental techniques at entry conditions. An alternative means of obtaining high-temperature melt properties is through ab initio molecular dynamics (AIMD) simulations. Such simulations are performed here to characterize the melt properties of enstatite (MgSiO3), which is prevalent in certain types of chondrites, and its constitutive oxides (SiO2 and MgO). The structure, thermodynamic properties (density, bulk modulus, heat capacity, and coefficient of thermal expansion), and transport properties (diffusion and viscosity) are computed across the entire liquid phase and agree well with the limited number of available experiments. The high fidelity AIMD results are compared against less accurate models for melt property determination, which include classical molecular dynamics simulations and empirical mixture rules. Properties obtained from these alternative models generally show large relative errors compared to experiment, with viscosity, in particular, having errors of up to 98%. The present results highlight the potential of AIMD simulations to provide “quantitatively accurate” properties for melts of complex silicates found in meteorites and terrestrial rocks.
Safety factor and turbulence dynamics dependence of the L-H power threshold on DIII-D
Authors: Yan Z. , Mckee G. R. , Gohil P. , Schmitz L. , Holland C. , Haskey S. R. , Grierson B. A. , Ke R. , Rhodes T. , Petty C.
Published: June 2019

The L-H transition power threshold (PLH) is found to have a significant dependence on q95, at ne ∼ 3.2 × 1019 m−3 on DIII-D. Comprehensive 2D turbulence and flow measurements in the plasma edge reveal the co-existence of two frequency bands of broadband modes across the L-H transition with higher flow shear at higher q95, which can help explain the linear decrease in PLH as q95 is increased from 3.5 to 4.9. Density fluctuation measurements by beam emission spectroscopy at higher q95 show that the lower frequency band (<20 kHz) of the broadband modes propagates in the ion diamagnetic direction in the lab frame (identified as an ion mode), whereas the higher frequency band (>20 kHz) propagates in the electron diamagnetic direction (identified as an electron mode). The turbulence amplitude at the plasma edge is higher at higher q95, implying a higher drive for a Reynolds stress driven zonal flow. At lower density, ne ∼ 1.5 × 1019 m−3, there is little dependence of PLH on q95. Linear CGYRO kinetic simulation has shown a switch from one mode to two modes at higher q95 at ne ∼ 3.2 × 1019 m−3 compared to lower q95. The ion temperature profile has been shown to strongly impact the dual mode characteristics with the increasing growth rate of the ion mode at a higher edge Ti gradient. The observations suggest that it may be possible to reduce the required input power to trigger the L-H transition for ITER if both the ion and electron modes are similarly driven in the plasma edge.