bluuebunny/crossref_metadata_2025 huggingface dataset:
POST-EXTRACTION REGENERATION OF JAW BONE SANOGENESIS MODEL
Authors: Muzykin M. I. , Iordanishvili A. K.
Published: September 2020

In this study the parallels of organs and tissue atrophy development in interaction with environmental objects are considered from the perspective of dentistry and maxillofacial surgery. The aim was to develop a model of reparative osteogenesis for visual representation of post-extraction atrophy of the jaws. The method of theoretical modeling reproduces the pathological process on "artificial copies" of diseases-their experimental models. Results. The essence of the process of post-traumatic osteogenesis of the bone tissue after tooth extraction is described, the mechanisms of development of post-extraction atrophy of the maxilla and alveolar part of the lower jaw are demonstrated. Using radiological research methods, the principle of implementing the concept of this model in clinical practice is shown. The presented data allow not only to interpret the principles of post-extraction osteogenesis, but also to evaluate the regenerative capabilities of a particular method of bone grafting aimed at increasing the height, width and 3D-alveolar augmentation of the jaw for the purpose of subsequent (or simultaneous) installation of dental implants. Conclusion: understanding the pathophysiological principles of bone regeneration helps to characterize the metabolic sufficiency of the defect walls and make a decision about the possibility of using хeno-, allo-, synthetic grafts or give preference to the use of autograft to increase the probability of a predicted positive result.
ВИКОРИСТАННЯ ЕЛЕКТРОННОГО НАВЧАЛЬНО-МЕТОДИЧНОГО КОМПЛЕКСУ З КРЕСЛЕННЯ В ПРОЦЕСІ ГРАФІЧНОЇ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ ТРУДОВОГО НАВЧАННЯ
Authors: Нищак Іван Дмитрович
Published: September 2020

У статті представлено загальну характеристику авторського електронного навчально-методичного комплексу (ЕНМК) з креслення, що використовується в процесі графічної підготовки майбутніх учителів трудового навчання в Дрогобицькому державному педагогічному університеті імені Івана Франка. Узагальнено основні дидактичні можливості ЕНМК: забезпечення системного та послідовного вивчення креслення відповідно до вимог, що ставляться до графічної компетентності вчителя трудового навчання; збільшення наочності навчального матеріалу, розширення способів його подання; організація автоматизованого педагогічного контролю на будь-якому етапі навчання; забезпечення роботи студентів з додатковими джерелами інформації; організація самостійної навчально-пізнавальної діяльності студентів; доступ до віддалених інформаційних ресурсів; підвищення індивідуалізації процесу навчання. Подано короткий аналіз основних змістових компонентів (модулів) авторського ЕНМК: методичного, навчального, контрольного, довідникового, інформаційно-пошукового. Охарактеризовано основні режими роботи в середовищі авторського ЕНМК, зокрема: режим електронного підручника; режими «База конструкторсько-графічної документації», «База технічних деталей», «Комплекс графічних завдань», «Електронний довідник», «Словник термінів». Висвітлено додаткові режими роботи з ЕНМК (робота з архівом електронних копій друкованої навчальної літератури, що знаходиться у вільному доступі та рекомендована для використання в процесі графічної підготовки майбутніх учителів трудового навчання; робота з Інтернет-ресурсами з питань навчання графічних дисциплін). Представлено результати впровадження ЕНМК з креслення в процес графічної підготовки майбутніх учителів трудового навчання в Дрогобицькому державному педагогічному університеті імені Івана Франка.
TECHNOLOGIES IMPROVING FOR KNOWLEDGE AND SKILLS ASSESSING OF STUDENTS OF PHYSICAL AND MATHEMATICAL SPECIALTIES IN E-LEARNING
Authors: Тмєнова Наталія Пилипівна , Сусь Богдан Богданович
Published: September 2020

Although the problems of obtaining educational information in e-learning have been successfully resolved, the testing of obtained knowledge still requires a solution. Principles of knowledge assessment by means of tests in mathematics subjects administered in e-learning environment have been developed. An algorithm of component analysis and formula expression indexing for automatic analysis is suggested. This approach allows diversifying the types of questions for consequent verification of knowledge in computer systems. Modification of the formula editor provides the creation of templates for formula entering and the use of indexing algorithm of the expression elements. This makes it possible to avoid ambiguity of responses entered by students. Tasks with computer verification of an analytical symbolic expression can be applied to automate the verification of skills and knowledge in natural sciences, in particular, physics, mathematics, by appropriate modification of the template.
Development of information technologies led to the development of new models of teaching and learning, especially in the field of mathematical sciences. It is shown that during experimental laboratory work in engineering subjects especially effective are those activities that combine the use of knowledge and skills acquired during the study of other related disciplines. It is shown that research based on interdisciplinary interaction has great potential.
In addition, the application and advantages of expert systems in open education to improve the teaching-learning process are discussed. It is proposed to use expert systems in the designing of laboratory works and tests. It is also shown how expert systems should be used to optimize the process of creating adaptive type laboratory works and to formulate individual test tasks. The application of the expert system is illustrated on the example of Discrete Mathematics.
THE IMPLEMENTATION EXPERIENCE OF STUDENTS MOBILE TRAINING IN THE FUNDAMENTALS OF LEADERSHIP AS A RESOURCE-ORIENTED FORM
Authors: Кононец Наталія Василівна , Нестуля Світлана Іванівна
Published: September 2020

In the article, the authors consider mobile learning as a form of resource-based learning of university students in the study of professionally-oriented disciplines. The advantages of mobile learning are revealed: using the latest technology in training; using lightweight, compact, portable devices in training; delivering blended, resource-oriented learning; providing a quality support for training in any format; teaching students with special needs; reducing the costs of educational support; using the new ways of educational content developing; providing the continuous targeted support for the educational process; creating a fun, exciting and comfortable learning experience. The conditions necessary for organization of mobile education in the educational environment of a modern university are described: availability of mobile devices for students and teachers; access to developed electronic educational resources (electronic textbooks and manuals, educational websites, distance learning courses); organization of feedback between the teacher and the student. On the example of the discipline "Fundamentals of Leadership" at the University of Ukoopspilks "Poltava University of Economics and Trade" (PUET), Ukraine, the authors propose ways of organizing mobile learning for distance students. The developed distance course (via distance learning platform Moodle) and the electronic manual on "Fundamentals of Leadership" for mobile devices (program Dr.Explain) are offered. The opportunities and benefits of Dr.Explain program, which allows you to create e-learning manuals for mobile learning, are demonstrated. The article states that Dr.Explain is a convenient and effective tool / aid for developing a variety of electronic educational resources, ranging from electronic lectures and manuals to complete electronic courseware package and educational Internet resources. The authors emphasize that for mobile learning, it is necessary to create electronic teaching aids in the formats supported by mobile devices.
КЛАСИФІКАЦІЙНІ КРИТЕРІЇ МАСОВИХ ВІДКРИТИХ ОНЛАЙН-КУРСІВ З ІНТЕЛЕКТУАЛЬНОЇ ВЛАСНОСТІ
Authors: Кірін Роман Станіславович , Хоменко Володимир Львович , Пащенко Олександр Анатолійович
Published: September 2020

У статті проаналізовано діапазон масових відкритих онлайн курсів з інтелектуальної власності на провідних платформах дистанційного навчання як елемент інформаційно-освітніх технологій. Розглянуто онлайн курси на платформах: Coursera, EdX, FutureLearn, SWAYAM, Canvas Network, Центр електронного навчання Всесвітньої організації інтелектуальної власності та інших. Коротко охарактеризовано ці платформи. Масові відкриті онлайн курси, що функціонують на базі цих платформ, стосуються різних аспектів інтелектуальної власності. Для кожного курсу зазначені: університет або організація, яка його створила; викладач; мова викладання; тривалість курсу і навантаження, необхідне для його освоєння; умови доступу до освітніх ресурсів курсу і отримання сертифіката про його проходження. Наведено кількісний розподіл курсів за країнами-розробниками дистанційних курсів з інтелектуальної власності. Лідерами тут є міжнародні організації та США. Розглянуто можливості доступу з точки зору мовної підготовки. Переважна більшість курсів доступна англійською мовою. Значна частина курсів доступна також російською. Було зроблено розподіл дистанційних курсів за тематичним спрямуванням. В основному онлайн курси розглядають лише загальні питання інтелектуальної власності. Замало курсів, які корисні для отримання ґрунтовних знань з конкретних питань. Особлива увага приділена такому важливому і цікавому аспекту, як-от можливості доступу до змісту і отримання сертифіката за проходження курсу. За цими критеріями всі курси були розділені на чотири групи. Було виявлено, що отримання сертифіката на переважній більшості дистанційних курсів з інтелектуальної власності на цих платформах є тією чи іншою мірою платним або сертифікат про закінчення курсу взагалі відсутній. Лише дев’ять курсів мають повністю безкоштовний доступ до освітніх ресурсів і отримання сертифіката.
THE WEBPORTAL OF V.O. SUKHOMLYNSKY STATE SCIENTIFIC AND PEDAGOGICAL LIBRARY OF UKRAINE AS AN INFORMATION RESOURCE FOR IMPLEMENTATION OF RESEARCH IN EDUCATION, PEDAGOGY AND PSYCHOLOGY
Authors: Березівська Лариса Дмитрівна , Пінчук Ольга Павловна , Вараксіна Наталія Володимирівна
Published: September 2020

In the context of the digital transformation of society and the integration of Ukrainian science and education into the European scientific and educational space, it becomes necessary to carry out high-quality, competitive scientific research which is demanded by theory and practice. The key factor in this process is the creation and successful functioning of a system of information and analytical support for research in education, pedagogy and psychology.
Today libraries accumulate materials for digital education and they can effectively serve as centres for learning throughout life. A library should be a full-fledged part of the open scientific and educational space. The paper presents to the scientific and educational community the educational information resources of the V. O. Sukhomlynsky State Scientific and Pedagogical Library of Ukraine (SSPL) of the National Academy of Educational Sciences of Ukraine (NAES of Ukraine). The authors feature the major characteristics of the SSPL web portal, its contents, functional specificity and purpose.
It has been substantiated that the library site meets the requirements of relevance, substantial completeness, usability, accessibility, topicality, it has its own unique style, harmoniously combines the traditions of the scientific and pedagogical library and new technological solutions. It has been substantiated that the SSPL web portal fully fulfils informational, search, educational, advertising, navigation functions and serves as an integrated resource, a powerful tool for promoting information and library products and services that meet modern scientific and educational needs of society.
The authors, among other things, have provided an overview of the SSPL electronic catalogue as the basis for scientific research. The relevance of the institution’s web portal has been statistically confirmed. It has been substantiated that the web portal is a powerful tool for conducting research in the issues of education, pedagogy and psychology. Also, its functioning is a significant factor that affects the image of both the SSPL and the NAES of Ukraine. The priority tasks for improving the web portal have been identified.
ÖTEKİNİN ÖTEKİSİ: HRİSTİYAN FEMİNİST DİNLER TEOLOJİLERİ
Authors: AKAY DAG Esra
Published: September 2020

Feminist teoloji ve dinler teolojisi yirminci yüzyılda ortaya çıkmış ve Hristiyan teolojisi içerisinde gelişmiş birbirinden farklı fakat aynı zamanda birbiriyle ilişkili teolojilerdir. Feminist teoloji, Hristiyan teolojisi içerisinde genel olarak Hristiyan geleneğinin ataerkil geçmişi, doktrinleri ve öğretilerini tarihsel ve toplumsal olarak ötekileştirilmiş kadın bakış açısıyla yeniden yorumlayan bir akademik disiplindir. Dinler teolojisi ise, yine Hristiyan teolojisi içerisinde bir akademik disiplin olup yirminci yüzyılda ortaya çıkmış Hristiyanlık dışındaki dinlerin hakikat söylemini ve bu dinlere inananların kurtuluşa erip eremeyeceğini inceler. Bu iki teoloji alanını buluşturan ortak nokta ise iki alanın da ötekilerle (biri dini öteki diğeri ise cinsiyet olarak öteki) ilgili teoriler üretmeleridir. Fakat feminist teolojide kadınlar öteki olarak özne iken dinler teolojisinde ötekiler nesne durumdadırlar, yani dinler teolojisi daha çok ötekine yaklaşımı betimleyici bir karaktere sahiptir.

Feminist dinler teolojisi ana damar olarak bilinen dinler teolojisindeki yaklaşımlara farklı bakış açıları sağlamıştır. Bu makalenin öncelik amacı feminist dinler teolojisini Türkçe okuyucuya tanıtmak ve bu teoloji içerisindeki çeşitliliği göstermektir. Burada feminist dinler teolojisi üç başlık altında kategorize edilmiş ve incelenmiştir; çoğulcu, çoğulculuk eleştirisi ve ötesi, post-kolonyalist. Öncü feminist teologların görüşleri her bir başlık altında ele alınmış ve bu kategorilerin öne çıkan yönlerinin gösterilmesi hedeflenmiştir. Kendi arasındaki çeşitliliğe rağmen, feminist dinler teolojisinin en ayırt edici yönü kadın tecrübesine dayanması ve bunu ön plana çıkarması olarak belirlenmiştir.
İBN ŞİHÂB EZ-ZÜHRÎ’YE (ÖL. 124/742) NİSPET EDİLEN MISIR MENŞELİ BİR PAPİRÜSTEKİ RİVÂYETLERİN MÜTÂBAAT BAKIMINDAN İNCELENMESİ
Authors: AKGÜN Hüseyin
Published: September 2020

Bu araştırmada daha önce Nabia Abbott (1897-1981) tarafından yayımlanan Chicago Oriental Institute Kütüphanesi’nde 17627 numara ile kayıtlı bulunan hicrî 2. yüzyılın sonu veya 3. yüzyılın başlarına ait olduğu tespit edilen bir papirüs ele alınarak tahlil edilmeye çalışılmıştır. Papirüsteki hadislerin tamamı (16 hadis) İbn Şihâb ez-Zührî’den (öl. 124/742) Ukayl b. Hâlid el-Eylî (öl. 144/761) aracılığıyla nakledilmektedir. Dolayısıyla Zührî’ye ait yazılı bir kaynaktan nakledildiği kuvvetle muhtemeldir. Bunların 14’ü merfû, 1’i mevkûf, 1’i maktûdur. Çalışmadaki diğer bir amaç ise farklı coğrafyalardaki hadis verileri arasındaki uyumu göstermektir. Bu doğrultuda papirüs sayfasındaki hadisler, rivâyetlerin Zührî’ye aidiyetleri ve sıhhati noktasında mütâbaat bakımından ele alınmıştır. Bu araştırmayla bazı oryantalistlerin hadislerin senedlerinin sistematik olarak vasledildiği yönündeki iddialarının da asılsız olduğu ortaya konulmaya çalışılmıştır. Farklı coğrafyalardaki hadis verileri arasındaki uyumu da göstermeyi amaçlayan bu çalışmada, Mısır özelinde hadiste yazılı edebiyatın yaygınlığı ve bunun sonraki musanniflere etkisi ortaya konulmaya da çalışılmıştır.
COUNSELING AND GUIDANCE PROGRAMS FOR WOMEN WITHIN THE CONTEXT OF PARADIGM SHIFT IN US PRISON SERVICES
Authors: KOÇ KANCA Hatice
Published: September 2020

The American criminal and correctional authorities have designed and implemented programs aiming rehabilitation of male prisoners alone, for many years, neglecting women prisoners and the correctional works for their problems. However, due to the increasing number of female prisoners in United States prisons, the state and federal correctional authorities have faced the fact that they focus on women-oriented problems and their solution. The awareness that has emerged over time has opened the door to the paradigm shift of American correctional authorities towards women. This awareness has led to the initiation of family protection programs in some states to address the needs of women prisoners and their families more respectfully. Moreover, it has led to the launch of several new programs: inmate mothers should be included in educational programs in order to respond to the physical, emotional and psychological needs of their children; those mothers should meet with their minor children and adolescents with games and various activities in special and child-friendly rooms outside the normal visiting room; it should be given additional visitation rights for those mothers who participate in parenting trainings; a new mother should be allowed to live with her infant in a private section for up to 18 months. In this article, parallel to this paradigm shift especially in the late 90s and early 2000s, some national and local correctional works and projects focused on the needs of female prisoners that was initially neglected but then taken into consideration due to the increasing number of women convicts and needs peculiar to them, will be examined. The treatments, medical processes, physical and mental treatment methods required by the clinical psychology offered to the prisoners based on prisoners’ needs are out of our scope. This study, rather, focuses on practices -their effects and efficiency- carried on successfully with combined efforts of criminal correctional authorities, psychologists, municipal and church officials, social service experts and volunteers that aim to support female prisoners, especially those with children.
GOOGLE ARAMA MOTORUNDA YAPILAN DİNÎ İÇERİKLİ ARAMALAR ÜZERİNE BETİMSEL BİR ARAŞTIRMA
Authors: TURANALP M. Fatih
Published: September 2020

İnsanoğlunun yaşam yolculuğunda sözlü ve yazılı kültürün doğuşu ve hayat pratiklerini dönüştürme noktasındaki etkileri insan temelli araştırmaların merkezinde olmuştur. Bu iki evreye ek olarak tekniğin teknolojiye dönüşümü ile iletişim imkânlarının genişlemesinin birleştiği noktada ortaya çıkan dijital kültür alanı da yeni nesil sosyal bilim araştırmalarının konularındandır. Teknolojik dönüşüm ve dijital kültürün en önemli etkileşim araçlarından olan internette insanların bilgiye ulaşmalarına yardımcı olan arama motorları, bu rehberlik işlevleri yanında elde ettikleri arama istatistikleri ile internetteki arama eğilimleri hakkında önemli veriler de elde etmektedir. Bunun yanında informal bir eğitim ortamı olan internetten diğer bilgiler yanında dinî bilgiye erişim de önemli bir toplumsal karşılığa denk düşmektedir. Bu araştırmada, internetteki aramaların büyük çoğunluğunun gerçekleştirildiği platform olan Google arama motoru üzerinde Türkiye ölçeğinde 2004-2019 yılları arasında yapılan dinî içerikli aramalar, betimsel nitelikli tarama modeli ile incelenmiştir. Araştırmaya konu başlıkların tespitinde ve bulguların karşılaştırılmasında ise Diyanet İşleri Başkanlığı’nın 2014 yılında yayımladığı Türkiye’de Dinî Hayat Araştırması’nın verilerinden yararlanılmıştır.
DEĞERLER EĞİTİMİNDE İZCİLİĞİN ÖNEMİ VE EĞİTSEL DEĞERİ ÜZERİNE NİTEL BİR ARAŞTIRMA
Authors: DAM Hasan
Published: September 2020

İzcilik, gönüllü, politik olmayan, uluslararası, üniformalı, çeşitli yaş gruplarındaki gençlerin zihinsel, fiziksel, ruhsal, sosyal, duygusal ve karakter gelişimine katkıda bulunan eğitimsel bir gençlik faaliyetidir. Bu çalışmanın amacı, izcilik hareketinin, değerler eğitimindeki önemini ve eğitsel değerini ve çocuklara kazandırdığı temel değerleri, izci lideri öğretmenlerin deneyimleri ve görüşlerine dayalı olarak ortaya koymaktır. Araştırmanın örneklemini farklı illerde görev yapan 43 izci lideri oluşturmaktadır. Araştırmanın verileri araştırmacı tarafından geliştirilen yapılandırılmış görüşme formu ile elde edilmiştir. Verilerin analizinde betimsel analiz yöntemi kullanılmıştır. Elde edilen sonuçlar, izciliğin okul eğitimini desteklediğini, çocukların ve gençlerin fiziksel, sosyal, psikolojik, duygusal ve ahlaki gelişimlerine önemli katkılar sağladığını ve değerler eğitiminde oldukça etkili bir faaliyet olduğunu göstermiştir. İzcilik çalışmalarının öğrencilere; sevgi, saygı, arkadaşlık, zararlı alışkanlıklardan uzaklaşma, doğruluk, sabır, dürüstlük, yardımlaşma ve paylaşma, sorumluluk bilinci, vatan ve millet sevgisi, cesaret, özgüven, disiplin, ekip ruhu, temizlik ve çevre bilinci gibi temel değerleri kazandırdığı tespit edilmiştir.
BUHÂRÎ’NİN HADİS USÛLÜ KONULARINA DAİR GÖRÜŞLERİ: EL-CÂMİ‘U’S-SAHÎH’İN “İLİM” BÖLÜMÜ ÇERÇEVESİNDE BİR DEĞERLENDİRME
Authors: ASAR Muhammet Ali
Published: September 2020

Hadis usûlü, Hz. Peygamber’e nispet edilen haberlerin sahîhini zayıfından ayırmayı gaye edinen, bunun için ihtiyaç duyulan kurallar ve ıstılahlardan bahseden ilimdir. Söz konusu usûl ihtiyaca göre oluşmaya başlamış, uygulanmış ve tedricî olarak geliştirilmiştir. Ancak usûle ilişkin kaide ve ıstılahların yazıya geçirilmesi yaklaşık olarak hicrî ikinci asrın sonlarından itibaren mümkün olmuştur. Üçüncü asırdaki müstakil hadis usûlü hüviyetini taşımayan eserlerde yer alan hadis usûl, kaide ve ıstılahları daha sonra telif edilen müstakil hadis usûlü eserlerine de kaynaklık etmiştir. Hicrî üçüncü asırda hadis usûlünün temel konularına temas eden eserlerden birisi de Buhâri’nin el-Câmi‘u’s-sahîh’idir. Buhârî, eserinin “kitâbü’l-ilm” bölümünde ağırlıklı olarak hadis usûlünün temel konularından olan hadis öğrenim ve öğretim (tahammül ve edâ) metotları üzerinde durmuş, bunun dışında hadis öğrencesinin ve hadis hocasının uyması gereken prensiplere (âdâbü’l-muhaddis ve âdâbü tâlibi’l-hadîs), hadis öğrenmek için çıkılan yolculuklara (er-rihle fî talebi’l-hadîs), Hz. Peygamber adına yalan söylemeye (kizbü’r-râvi) ve hadislerin korunması ve yazılmasına (hıfz ve kitâbet) dair konulara değinmiştir. Bu konuları, özgün bir yaklaşımla incelemiş, hadis rivayetleriyle oluşturduğu kurguyla delillendirmiş, hadis ilmindeki şöhretli âlimlerin görüşleriyle de delillerini güçlendirmiştir. Bu makale, hadis usûlü konularını “ilim” bölümü özelinde derinlemesine inceleyip yorumlayarak, Buhârî’nin hadis usûlü ilmine katkılarını ortaya koymayı amaçlamaktadır.
Tindak Tutur Memuji dalam Film Kaze Tachinu
Authors: Maulida Nimatul
Published: September 2020

This study aims to describe the use of Japanese compliment expression in Kaze Tachinu's movie. It includes the types of compliment, the forms of expression and the categories of compliment topics. The data of this study were taken from the utterances of characters which contain compliment expressions. The type of compliment expression, which are bound and unbound compliments, were then analyzed based on Yuan's theory. The forms of compliment expressions were analyzed based on the theories of Huang and Tseng, and the topic of compliment was analyzed by using Holmes's theory. This type of research is descriptive qualitative research with a pragmatic approach. The results of the study found 2 types of unbound compliments, they were direct and indirect compliment, each of which got 4 topics. And then for the bound compliment , there were found 13 expressive of compliments that consist of realization to complimenting directly and complimenting indirectly. Expressive forms of compliment in indirect compliment were found to be 11 forms, they are surprise, explanation, evaluation, knowing, offering reward, contrast, assumption, admiration, appreciation, request and pleasing. Direct compliment are very varied with the existence of evaluative markers, which are vocabulary that has the same meaning.Â
KECERDASAN EMOSIONAL TOKOH TOTTO CHAN DALAM NOVEL MADOGIWA NO TOTTO CHAN KARYA TETSUKO KUROYANAGI MENURUT TEORI GOLEMAN SEBUAH ANALISIS PSIKOLOGI
Authors: Faizah Noor Laili , Oemiati Sri
Published: September 2020

This research is a descriptive psychological analysis study according to Goleman's theory of the emotional intelligence of Totto Chan in the novel Madogiwa no Totto chan by Tetsuko Kuroyanagi. The purpose of this study was to determine the level of emotional intelligence of Totto Chan in the novel Madogiwa No Totto Chan by Tetsuko Kuroyanagi. The results of the analysis in this study indicate that the character of Totto Chan has seven elements of emotional intelligence. This is indicated by the confidence to succeed very high, always trying to find out and try new things, the main character plans well and does not despair to achieve goals when intending to do something, the main character has self-control in adjusting his desires to the demands of the environment, the main character has a very high relationship with other people where the main character is able to understand their situations and conditions, the main character communicates well, the main character can be cooperative with others. Therefore Totto Chan's emotional intelligence is high.Â
Efektivitas Implementasi Tools of Control pada Kinerja Perusahaan BUMN
Authors: Alvyra Noormalyta Trysna Devy Putri Permata Santy  , Novita
Published: September 2020

The objective of this study is to analyse the effectiveness of implementation management controls consists of the result, action, personnel, and cultural control to company performance with motivation as a moderating variable. The respondents of this research are employees at Perum Perindo. Data were collected through observation, documentation, and questionnaires. Descriptive and verification analysis methods were employed to verify the hypothesis and structural modelling with SmartPLS. The results indicate that action and cultural control are positively and significantly associated with company performance. Motivation only moderates the relationship between the result and cultural control.
Abstrak
Tujuan dari penelitian ini untuk melihat efektivitas dari implementasi alat pengendalian (tools of control) yang terdiri dari result control, action control, personnel control, dan cultural control terhadap kinerja perusahaan dengan motivasi sebagai pemoderasi. Responden yang digunakan adalah karyawan Perum Perindo. Data dikumpulkan dengan menggunakan observasi, dokumentasi, dan kuesioner. Metode analisis deskriptif dan analisis verifikatif digunakan untuk menguji hipotesis dan model struktural dengan SmartPLS. Pengujian variabel tools of control memperlihatkan hasil bahwa action control dan cultural control yang memiliki pengaruh positif terhadap kinerja perusahaan. Motivasi hanya memoderasi hubungan result dan cultural control.
Developing Knowledge among Dentists about Somatic Symptom Disorder in Dental Patients-A Mini Review
Authors: Hassan Khamis A , E Khier Salwa
Published: September 2020

Dentists are not trained in dental school to identify and recognize patients with Somatic Symptom Disorder (SSD) before initiating dental treatment. Lack of such recognition could result in misdiagnosis, inefficient management of treatment time, and dental treatment failure. The aim of this mini review is to develop awareness and provide basic knowledge about SSD among dentists. Several recommendations are made to assist dental students and dentists in attaining basic knowledge and training related to this psychiatric disorder.
Gorlin-Goltz Syndrome: A Familial Case Report
Authors: Romero Hugo , Medina Montoya Charlotte , Yanes Moya Hernan Enrique , Umanzor Vilma
Published: September 2020

Gorlin-Goltz Syndrome (GGS) also known as Nevoid Basal Cell Carcinoma Syndrome is a rare autosomal dominant disorder. Is characterized for presenting some clinical features such as palmar pits, fused eyebrows, multiple odontogenic keratocyst, which are considered some of the most common signs. In our case, a rare familial case highlights awareness when a member of the family is diagnosed with this condition, and the probability to find in one the first degree relative. Once again it is confirmed that is impossible to determine without the radiographical analysis such as Cone Beam Computed Tomography (CBCT), ortophantomography, magnetic resonance imaging, to corroborate with clinical aspects, advising that, this could be the best way for the sake of patients benefit. Many treatments less aggressive have been proposed along the years, with a lower percentage of success against the traditional way, specifically surgical enucleation/marsupialization combined with peripheral osteotomy, in order to approach the variable behavior of nevoid basal cell carcinoma syndrome. The early diagnosis is considered the key to well manage this kind of disease, due to its aggressiveness, potential to become malignant, and in some cases, with a silent destructive pattern.
The Hidden Ideology in Objective Measurements - an Example from a Specific Tool for Quality Assurance in Schools
Authors: Kaminski Ricardo
Published: September 2020

There is an inherent ideological discrepancy in the idea and practice of Quality Assurance (QA) within the welfare sector. While QA sails under the objective, instrumental and apolitical flag of strictly measuring the quality of the entity to which it is applied1 , the entity itself – the specific school unit, municipality or even whole country – is expected to adapt to the parameters imposed upon it. This in turn governs the direction taken in work, activities, and discourse, which should per se be understood as highly political (Agevall, 2005, p. 21; Forsell & Ivarsson Westberg, 2014, p. 222).
Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer
Authors: Fiore Michael A. , Raisman Jordan C. , Wong Narayan H. , Hudson André O. , Wadsworth Crista B.
Published: September 2020

Nonpathogenic Neisseria transfer mutations encoding antibiotic resistance to their pathogenic relative Neisseria gonorrhoeae. However, the resistance genotypes and subsequent phenotypes of nonpathogens within the genus have been described infrequently. Here, we characterize the minimum inhibitory concentrations (MICs) of a panel of Neisseria (n = 26)—including several commensal species—to a suite of diverse antibiotics. We furthermore use whole genome sequencing and the Comprehensive Antibiotic Resistance Database Resistance Gene Identifier (RGI) platform to predict putative resistance-encoding mutations. Resistant isolates to all tested antimicrobials including penicillin (n = 5/26), ceftriaxone (n = 2/26), cefixime (n = 3/26), tetracycline (n = 10/26), azithromycin (n = 11/26), and ciprofloxacin (n = 4/26) were found. In total, 63 distinct mutations were predicted by RGI to be involved in resistance. The presence of several mutations had clear associations with increased MIC such as DNA gyrase subunit A (gyrA) (S91F) and ciprofloxacin, tetracycline resistance protein (tetM) and 30S ribosomal protein S10 (rpsJ) (V57M) and tetracycline, and TEM-type β-lactamases and penicillin. However, mutations with strong associations to macrolide and cephalosporin resistance were not conclusive. This work serves as an initial exploration into the resistance-encoding mutations harbored by nonpathogenic Neisseria, which will ultimately aid in prospective surveillance for novel resistance mechanisms that may be rapidly acquired by N. gonorrhoeae.
Characterization of Multidrug Resistance Patterns of Emerging Salmonella enterica Serovar Rissen along the Food Chain in China
Authors: Xu Xuebin , Biswas Silpak , Gu Guimin , Elbediwi Mohammed , Li Yan , Yue Min
Published: September 2020

Salmonella spp. are recognized as important foodborne pathogens globally. Salmonella enterica serovar Rissen is one of the important Salmonella serovars linked with swine products in numerous countries and can transmit to humans by food chain contamination. Worldwide emerging S. Rissen is considered as one of the most common pathogens to cause human salmonellosis. The objective of this study was to determine the antimicrobial resistance properties and patterns of Salmonella Rissen isolates obtained from humans, animals, animal-derived food products, and the environment in China. Between 2016 and 2019, a total of 311 S. Rissen isolates from different provinces or province-level cities in China were included here. Bacterial isolates were characterized by serotyping and antimicrobial susceptibility testing. Minimum inhibitory concentration (MIC) values of 14 clinically relevant antimicrobials were obtained by broth microdilution method. S. Rissen isolates from humans were found dominant (67%; 208/311). S. Rissen isolates obtained from human patients were mostly found with diarrhea. Other S. Rissen isolates were acquired from food (22%; 69/311), animals (8%; 25/311), and the environment (3%; 9/311). Most of the isolates were resistant to tetracycline, trimethoprim-sulfamethoxazole, chloramphenicol, streptomycin, sulfisoxazole, and ampicillin. The S. Rissen isolates showed susceptibility against ceftriaxone, ceftiofur, gentamicin, nalidixic acid, ciprofloxacin, and azithromycin. In total, 92% of the S. Rissen isolates were multidrug-resistant and ASSuT (27%), ACT (25%), ACSSuT (22%), ACSSuTAmc (11%), and ACSSuTFox (7%) patterns were among the most prevalent antibiotic resistance patterns found in this study. The widespread dissemination of antimicrobial resistance could have emerged from misuse of antimicrobial agents in animal husbandry in China. These findings could be useful for rational antimicrobial usage against Salmonella Rissen infections.
Thermal Deformation Defect Prediction for Layered Printing Using Convolutional Generative Adversarial Network
Authors: Xu Jinghua , Wang Kang , Zhang Shuyou , Yi Guodong , Tan Jianrong , Luo Sheng , Pang Jihong
Published: September 2020

This paper presents a Thermal Deformation defect prediction method for layered printing using Convolutional Generative Adversarial Network (CGAN). Firstly, the original manifold mesh is converted into layered image in Printing Coordinate System (PCS). The trajectory inside layered image with various infill patterns are generated for making comparisons. Inspired by monocular vision and even binocular vision, the mathematical model of thermal defect prediction via infrared thermogram is built via virtual printing of Digital Twins to preset the initial parameters of Artificial Neural Network (ANN). Particularly, the depth convolution is used to extract multi-scale features of layered image. By using transfer learning techniques to identify small sample data, the CGAN is employed to build the nonlinear implicit relations between thermal deformation and multi-scale features. The binocular stereo vision laser scanner is used to determine the actual thermal deformation of the target printed objects. The shape deformation dissimilarity can be succinctly calculated by evaluating the surface profile error via mesh registration between the original source and target mesh model. The proposed method is verified by physical experiments. The experiment proved that the proposed method can deal with the thermal deformation with more optimal parameters, which contributes to performance forward design of irregular complex parts regarding diversified customized requirements.
Potential Use of Environmental Biological Samples for Retrospective Electron Paramagnetic Resonance Dosimetry of Radiation Accidents
Authors: Lu Chia-Chun , Lin Hsin-Hon , Hsu Ching-Han , Wang Fu-Nien , Lin Jao-Perng , Lai Lu-Han
Published: September 2020

Retrospective dosimetry is one of the most important tools of accident dosimetry for environmental dose estimation when large-scale radiological incidents and nuclear mass-casualty events occur. Electron paramagnetic resonance (EPR) dosimetry is a physical method for the retrospective assessment of absorbed dose based on the measurement of stable radiation-induced radicals in materials. Different from the fast disappearance of radials in aqueous systems, the radials can persist indefinitely in some organized matrices. Therefore, environmental materials contained in creatures from sea or land can be potentially used as environmental dosimeters for a retrospective dose analysis. This study aims to assess the EPR signals of free radicals from environmental biological samples, potentially for the retrospective dose estimation. The evaluated samples involve ox bone, cyclina shell, clam shell, chitin from squid, and human tissue (enamel and fingernail). First, we dehydrate and grind these materials to the powder with different sizes. Subsequently, all materials were irradiated with different doses ranging from 5 Gy to 50 Gy using 6 MV linear accelerator, and EPR spectra of these materials were obtained from the calculation of peak-to-peak amplitudes. The dose-response curve of EPR signals versus irradiated dose for the six materials shows good linearity (R2~0.99). For the grain-size experiment, the ox bone and tooth with 0.5 mm, the chitin with 0.1 mm, and the others with 1 mm have the strongest signal. For the storage temperature experiment, the optimal temperature of storage is at −20 °C for tooth, fingernail, ox bone, and chitin, at 45 °C for clam shell and cyclina shell where the signal fading is minimal. In conclusion, the developed dose-response curves of the six materials may potentially help a fast, rough retrospective dose reconstruction under the environment when radiation accidents occur.
Material Erosion and Dust Formation during Tungsten Exposure to Hollow-Cathode and Microjet Discharges
Authors: Marascu Valentina , Stancu Cristian , Satulu Veronica , Bonciu Anca , Grisolia Christian , Dinescu Gheorghe
Published: September 2020

Tungsten erosion and dust occurrence are phenomena of great interest for fusion technology. Herein, we report results concerning the material damage and dust formation in the presence of high temperature and large area or concentrated discharges in helium and argon. In order to generate adequate plasmas, we used tungsten electrodes in two experimental discharge systems, namely a hollow discharge and a microjet discharge. In both exposure cases, we noticed surface modification, which was assigned to sputtering, melting, and vaporization processes, and a significant dust presence. We report the formation on electrode surfaces of tungsten fuzz, nano-cones, nanofibers, and cauliflower- and faced-like particles, depending on the discharge and gas type. Dust with various morphologies and sizes was collected and analyzed with respect to the morphology, size distribution, and chemical composition. We noticed, with respect to erosion and particle formation, common behaviors of W in both laboratory and fusion facilities experiments.
Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin
Authors: Kim Minsu , Im Seowoo , Cho Yoon keun , Choi Cheoljun , Son Yeonho , Kwon Doyoung , Jung Young-Suk , Lee Yun-Hee
Published: September 2020

Soy isoflavones are bioactive phytoestrogens with known health benefits. Soybean embryo extract (SEE) has been consumed as a source of isoflavones, mainly daidzein, glycitein, and genistein. While previous studies have reported the anti-obesity effects of SEE, this study investigates their molecular mechanisms and the synergistic effects of co-treatment with SEE and enzymatically modified isoquercitrin (EMIQ). SEE upregulated genes involved in lipolysis and brown adipocyte markers and increased mitochondrial content in differentiated C3H10T1/2 adipocytes in vitro. Next, we use a high-fat diet-induced obesity mouse model to determine the anti-obesity effect of SEE. Two weeks of single or combined treatment with SEE and EMIQ significantly reduced body weight gain and improved glucose tolerance. Mechanistically, SEE treatment increased mitochondrial content and upregulated genes involved in lipolysis in adipose tissue through the cAMP/PKA-dependent signaling pathway. These effects required a cytosolic lipase adipose triglyceride lipase (ATGL) expression, confirmed by an adipocyte-specific ATGL knockout mouse study. Collectively, this study demonstrates that SEE exerts anti-obesity effects through the activation of adipose tissue metabolism and exhibits a synergistic effect of co-treatment with EMIQ. These results improve our understanding of the mechanisms underlying the anti-obesity effects of SEE related to adipose tissue metabolism.
Targeting Mitochondria in Melanoma
Authors: Aminzadeh-Gohari Sepideh , Weber Daniela D. , Catalano Luca , Feichtinger René G. , Kofler Barbara , Lang Roland
Published: September 2020

Drastically elevated glycolytic activity is a prominent metabolic feature of cancer cells. Until recently it was thought that tumor cells shift their entire energy production from oxidative phosphorylation (OXPHOS) to glycolysis. However, new evidence indicates that many cancer cells still have functional OXPHOS, despite their increased reliance on glycolysis. Growing pre-clinical and clinical evidence suggests that targeting mitochondrial metabolism has anti-cancer effects. Here, we analyzed mitochondrial respiration and the amount and activity of OXPHOS complexes in four melanoma cell lines and normal human dermal fibroblasts (HDFs) by Seahorse real-time cell metabolic analysis, immunoblotting, and spectrophotometry. We also tested three clinically approved antibiotics, one anti-parasitic drug (pyrvinium pamoate), and a novel anti-cancer agent (ONC212) for effects on mitochondrial respiration and proliferation of melanoma cells and HDFs. We found that three of the four melanoma cell lines have elevated glycolysis as well as OXPHOS, but contain dysfunctional mitochondria. The antibiotics produced different effects on the melanoma cells and HDFs. The anti-parasitic drug strongly inhibited respiration and proliferation of both the melanoma cells and HDFs. ONC212 reduced respiration in melanoma cells and HDFs, and inhibited the proliferation of melanoma cells. Our findings highlight ONC212 as a promising drug for targeting mitochondrial respiration in cancer.
Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis
Authors: Lee Jinhee , Son Min Ji , Son Chei Yun , Jeong Gwang Hun , Lee Keum Hwa , Lee Kwang Seob , Ko Younhee , Kim Jong Yeob , Lee Jun Young , Radua Joaquim , Eisenhut Michael , Gressier Florence , Koyanagi Ai , Stubbs Brendon , Solmi Marco , Rais Theodor B. , Kronbichler Andreas , Dragioti Elena , Vasconcelos Daniel Fernando Pereira , Silva Felipe Rodolfo Pereira da , Tizaoui Kalthoum , Brunoni André Russowsky , Carvalho Andre F. , Cargnin Sarah , Terrazzino Salvatore , Stickley Andrew , Smith Lee , Thompson Trevor , Shin Jae Il , Fusar-Poli Paolo
Published: September 2020

This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.
The Promise of Circulating Tumor DNA (ctDNA) in the Management of Early-Stage Colon Cancer: A Critical Review
Authors: Chakrabarti Sakti , Xie Hao , Urrutia Raul , Mahipal Amit
Published: September 2020

The current standard treatment for patients with early-stage colon cancer consists of surgical resection, followed by adjuvant therapy in a select group of patients deemed at risk of cancer recurrence. The decision to administer adjuvant therapy, intended to eradicate the clinically inapparent minimal residual disease (MRD) to achieve a cure, is guided by clinicopathologic characteristics of the tumor. However, the risk stratification based on clinicopathologic characteristics is imprecise and results in under or overtreatment in a substantial number of patients. Emerging research indicates that the circulating tumor DNA (ctDNA), a fraction of cell-free DNA (cfDNA) in the bloodstream that originates from the neoplastic cells and carry tumor-specific genomic alterations, is a promising surrogate marker of MRD. Several recent studies suggest that ctDNA-guided risk stratification for adjuvant therapy outperforms existing clinicopathologic prognostic indicators. Preliminary data also indicate that, aside from being a prognostic indicator, ctDNA can inform on the efficacy of adjuvant therapy, which is the underlying scientific rationale for several ongoing clinical trials evaluating ctDNA-guided therapy escalation or de-escalation. Furthermore, serial monitoring of ctDNA after completion of definitive therapy can potentially detect cancer recurrence much earlier than conventional surveillance methods that may provide a critical window of opportunity for additional curative-intent therapeutic interventions. This article presents a critical overview of published studies that evaluated the clinical utility of ctDNA in the management of patients with early-stage colon cancer, and discusses the potential of ctDNA to transform the adjuvant therapy strategies.
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner
Authors: Rieckhoff Johanna , Meyer Felix , Classen Sandra , Zielinski Alexandra , Riepen Britta , Wikman Harriet , Petersen Cordula , Rothkamm Kai , Borgmann Kerstin , Parplys Ann Christin
Published: September 2020

Chromosomal instability (CIN) is an emerging hallmark of cancer and its role in therapeutic responses has been increasingly attracting the attention of the research community. To target the vulnerability of tumors with high CIN, it is important to identify the genes and mechanisms involved in the maintenance of CIN. In our work, we recognize the tumor suppressor gene Phosphatase and Tensin homolog (PTEN) as a potential gene causing CIN in triple-negative breast cancer (TNBC) and show that TNBC with low expression levels of PTEN can be sensitized for the treatment with poly-(ADP-ribose)-polymerase 1 (PARP1) inhibitors, independent of Breast Cancer (BRCA) mutations or a BRCA-like phenotype. In silico analysis of mRNA expression data from 200 TNBC patients revealed low expression of PTEN in tumors with a high CIN70 score. Western blot analysis of TNBC cell lines confirm lower protein expression of PTEN compared to non TNBC cell lines. Further, PTEN-deficient cell lines showed cellular sensitivity towards PARP1 inhibition treatment. DNA fiber assays and examination of chromatin bound protein fractions indicate a protective role of PTEN at stalled replication forks. In this study, we recognize PTEN as a potential CIN-causing gene in TNBC and identify its important role in the replication processes.