bluuebunny/crossref_metadata_2025 huggingface dataset:
Personal and Communicative Qualities of Teachers, Defining the Subject-Subject Interaction with Students
Authors:   Psychological Institute of the Russian Academy of Education, Sunnatova Rano I.
Published: October 2020

The relevance of the topic under study is conditioned by the dissatisfaction of both teachers and students with their relations with each other, which primarily blocks the formation of subjectness, student activity, including that in educational activities. The purpose of the study presented in the article is to study the possibility of predetermining constructiveness of interaction between teachers and students through personal and communicative qualities of teachers. Presumably, the constructive characteristics of teachers’ self-attitude can predetermine formation of professionally significant communicative characteristics: accepting personality of others as they are (lack of personality evaluation); building trust with students; creation the feeling of confidence in one’s capabilities in another person; teacher’s ability to stop him/herself from putting pressure on another person and rejection of manipulation, which, in turn, acts as a condition that predetermines the subject-subject interaction with students. The study was carried out on a sample of teachers (n = 72) of the middle and high school level of a Moscow general education school and students in grades 7–11 (n = 402) of the same school using the author’s methodology called “Features of self-attitude”, which includes the following scales: “faith in oneself” – allowing to study the constructiveness/destructiveness of self-attitude; mindfulness; autosympathy; self-esteem; self-management, and the technique called “Communicative qualities of teachers.” The results of correlation analysis using the Spearman’s coefficient confirmed the hypotheses. The obtained empirical data on the influence of the emotional component of the teacher’s self-attitude on the type of interaction with students allows us to state that there is a need for introduction of psychological support into the practice of supporting teachers’ activities. Traditionally, psychological service has been more focused on students and their parents, while personality of a teacher, who is definitely one of the most important subjects in education, does not get any proper psychological support.
Viability of Urban Residents: Content of the Concept, Theoretical and Empirical Possibilities of Its Application
Authors:   Institute of Psychology of Russian Academy of Science, Drobysheva Tatiana V. , Emelyanova Tatiana P. ,   Institute of Psychology of Russian Academy of Science
Published: October 2020

The purpose of the study presented in the article is to theoretically and methodologically substantiate the appropriateness of applying the concept of “viability of urban residents” in the studies of urban social psychology. Interdisciplinary analysis of approaches to the study of the problem of “human being and the city” has been carried out. It is noted that introduction of the concept of “viability of urban residents” into scientific circulation will allow, on the one hand, to study factors and mechanisms of vital resources of different groups of urban residents from a new perspective, and, on the other hand, it will expand the subject area of psychology of large social groups. The task that we set was to include the category of “viability of city residents” in the existing thesaurus of concepts used in the study of social psychology of the city. It has been shown that the existing directions of research on the perception of the city, social representations of residents, satisfaction with life in the city, approaches through phenomena of identity and values of residents, viewed from different angles, provided understanding of the variety of psychological factors of urban residents’ viability. It has been stated that the problem of accumulating this knowledge by means of introducing a concept which synthesizes various aspects of social psychology of urban residents is becoming urgent. It has been shown that this role can be fulfilled by the concept of residents’ viability, which, due to its many aspects, will be useful for studying the potential that provides a productive and proactive start in the life of large social groups of urban residents (age-related, ethnic, religious, professional, etc.). Such components of the viability of large groups of urban residents as cognitive, value-affective, and motivational-volitional components have been distinguished. The content of each of these components has been discussed and ways of their empirical research have been proposed when comparing viability of urban residents with different economic, geographical, environmental and cultural characteristics.
Content Transformation of the “Significant Other” Representation in a Transitive Society
Authors:   Saratov State University, Ryaguzova Elena V.
Published: October 2020

The purpose of the study presented in the article is theoretical reflection on the meaningful transformation of the “Significant Other” representation in a transitive society. It describes the main attributes of a transitional society (instability, uncertainty, projectivity, multidirectionality, multivariability, innovativeness, etc.), indicating its institutional and value-related changes, their irreversibility, as well as unity of preservation and negation of rules, norms and values, old and new worldviews and world orders, their conflict and alternativeness. The study analyses features of personal socialization in a transitive society, highlights similarities and differences in the content, mechanisms and determinants of socialization. The author’s attention is focused on qualitative changes in the representations of Significant Other, which are the result of individual’s interaction with the Others, based not so much on perceptual processes, but rather on living and experiencing certain experiences and constructing existential meanings. It substantiates the increase in the number of representations of “Significant Other” in the modern society, due to expansion of communicative space, total globalization processes, development and dissemination of various information technologies. It is argued that meaningful content of the representation of “Significant Other”, is, on the one hand, expanding, including a wider range of ideas about significant figures (familiar and unfamiliar in everyday life, symbolic and virtual), a variety of assessments and established relations to the world, Others and oneself, while, on the other hand, it is reduced and schematized, broken up into separate components of significance (referentiality, attraction, power), and sometimes depersonalized, losing the descriptive and evaluative attributes of individuality and uniqueness. The applied aspect of the problem under study is the possibility of using the obtained theoretical generalizations in the practice of socio-psychological support of a person in the process of socialization (including digital socialization) in a modern transitive society.
THE EXPLORATION OF LOCAL WISDOM VALUES OF PERFORMING ARTS: AN ART OF KUDA LUMPING SARIMPI
Authors: Rahmawati Eni , Putranta Himawan
Published: October 2020

Purpose of the study: This research aims to find the values of local wisdom in the Kuda Lumping Sarimpi performing arts in the Tegal Laos community.
Methodology: This research uses qualitative research methods and data collection techniques using observation techniques, interviews, and documentation. The data validity checking technique uses triangulation which includes source triangulation and technique triangulation. Data analysis techniques use interactive analysis techniques which include data reduction, data display, and arrange conclusions.
Main Findings: The Kuda Lumping Sarimpi had religious, social, and aesthetic values. Religious value is the use of music to accompany the blessing of the Prophet Muhammad. Social values as a unifying medium for the people of Tegal Laos, Brebes, Central Java in maintaining cooperation. Cultural aesthetic value is shown by the beauty of dance, musical instruments, poetry, and uniform.
Applications of this study: The results of the research provide a descriptive view for the community, practitioners, researchers, and the government to work together in preserving all forms of local wisdom such as dance so that any local wisdom in each region can be sustainable and enjoyed by future generations. Therefore, this local wisdom can become a characteristic of the community that attracts tourists.
Novelty/Originality of this study: In this research, the novelty element that is raised is displaying the values of local wisdom that are beneficial to the general public in the Kuda Lumping Sarimpi art community in Tegal Laos, Brebes, Central Java, Indonesia.
The Paths to Realizing Reconciliation: Indigenous Consultation in Jasper National Park
Authors: Johnston Jason W. , Mason Courtney
Published: October 2020

Diverse Indigenous nations have traditional territories inside Jasper National Park (JNP), but the park was established without consultation with local Indigenous communities. Parks were marketed as empty landscapes, which celebrated romantic ideas of European colonial expansion. The current representations of Indigenous Peoples in interpretive content still reflect this lack of consultation. This research was guided by Indigenous methodologies. Data was collected through interviews with Jasper Indigenous Forum (JIF) members and the JNP management team. Findings indicate that JIF members want increased representation and greater control over how their histories and cultures are presented. Park management needs to work in close consultation with the JIF if they want to improve Indigenous representations in the park and support processes of reconciliation.
VERMICOMPOST AS A POTENTIAL ADSORBENT FOR THE ADSORPTION OF METHYLENE BLUE DYE FROM AQUEOUS SOLUTIONS
Authors: CİĞEROĞLU Zeynep , YILDIRIR Eyüp
Published: October 2020

Abstract: Vermicompost (VC) as a low cost and waste-derived material was used as an adsorbent to remove textile dye effluents from the wastewater. Methylene blue (MB) was selected as a representative of dye effluents and its adsorption to VC was investigated. The effect of parameters such as pH, adsorption time, and the initial concentration of MB were determined via lab-scale batch experiments. The highest adsorption capacity of VC was reached when the pH of the solution was 4. The equilibrium was maintained after 90 minutes of operation since the removal percentage of MB was stabilized at 99%. The pseudo-second-order kinetic model described the most appropriate adsorption kinetic behavior. BothLangmuir (R 2 =0.9891) and Freundlich isotherms (R 2 =0.9895) fitted very well to the experimental data. Based on these results, vermicompost can be evaluated as an alternative adsorbent for the removal of dye effluents.
Institucionalización de las relaciones internacionales en Colombia: aproximación a la consolidación de la disciplina
Authors: Guerra Molina René Alonso , Virviescas Peña John Anderson , Badilllo Sarmiento Reynell
Published: October 2020

El artículo busca aproximarse al proceso de institucionalización de las relaciones internacionales como una disciplina autónoma en la educación superior colombiana. Se analizan los programas de pregrado a través de su localización, la naturaleza de la institución, denominaciones, justificaciones, núcleo básico de conocimiento y la acreditación de alta calidad. Como resultado, se obtiene que, desde finales de la década de los noventas, la oferta de programas de relaciones internacionales ha aumentado considerablemente y esto ha permitido la institucionalización de la disciplina, lo que se ha materializado en decisiones oficiales y el fortalecimiento de una comunidad epistémica. Asimismo, identificamos una notable centralización de la formación en relaciones internacionales en la capital del país, así como una concentración de su oferta en universidades privadas y muy pocos programas con acreditación de alta calidad. Si bien este panorama refleja un fortalecimiento disciplinar, también persiste una notable heterogeneidad con respecto a las concepciones que las universidades tienen sobre las relaciones internacionales alrededor de su lugar en las ciencias sociales (como parte de la ciencia política, como disciplina autónoma o como un proyecto multidisciplinar).
Exploring Motivation, Satisfaction and Revisit Intention of Ecolodge Visitors
Authors: Simpson Greg D. , Sumanapala Daminda P. , Galahitiyawe Nilakshi W.K. , Newsome David , Perera Priyan
Published: October 2020

Purpose – This paper demonstrates that the recommendations regarding visitor satisfaction and revisit intention reported in the international literature apply to the management of ecolodges in Sri Lanka. Design/Methodology/Approach – Data from 362 self-report questionnaires completed by visitors between January 2014 and January 2015 were analysed by structural modelling using SPSS and AMOS to confirm the significance that reported direct and indirect relationships of the latent factors ecolodge attributes, tourist motives, visitor satisfaction, and revisit intention have for Sri Lankan ecolodges. Findings – Responses of visitors to Sri Lankan ecolodges were like those of ecolodge visitors in other countries. Ecolodge attributes had a strong direct influence on both international tourist motives to visit Sri Lanka and visitor satisfaction. Further, travel motives and satisfaction have a substantial direct influence on tourist intentions to revisit individual ecolodges and hence Sri Lanka more broadly. Originality of the research – Having confirmed that the factors which influence satisfaction and revisit intention of visitors to Sri Lankan ecolodges are consistent with the research findings from other countries, this is the first study to demonstrate that recommendations from the international ecolodge literature are applicable to and can inform the management and sustainability of ecolodges in Sri Lanka.
Development of UV-vis and FTIR Partial Least Squares models: comparison and combination of two spectroscopy techniques with chemometrics for polyphenols quantification in red wine
Authors: Miramont Clément , Jourdes Michael , Teissedre Pierre-Louis
Published: October 2020

Polyphenolic compounds are considered to have a major impact on the quality of red wines. Sensory perception, such as astringency and bitterness, are mainly related to condensed tannin, while colour intensity and evolution is due to anthocyanin composition. Therefore, the quick analytical measurement of phenolic compounds appears to be a real challenge for wine monitoring. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-vis) spectroscopy with chemometrics are good candidates for predicting polyphenolic contents in wines, but they have not yet been compared in terms of efficiency of each wavelength area. Thus, the possibility of combining the two areas has not been investigated.This work sought to determine the tannin and anthocyanin content of ninety-two wines. The wine selection covered different vintages, varieties and regions. Tannin concentration was analysed by precipitation with protein and polysaccharide and by the Bate-Smith assay. Free anthocyanin concentration was analysed by bisulfite bleaching and the monomers/polymers ratio was analysed using the Adams-Harbertson method. Molecular anthocyanin concentration was also obtained by HPLC/UV-vis. Two spectra were collected using UV-vis and FTIR devices. The data collected were statistically analysed using the partial least squares (PLS) regression method.The correlations obtained were relevant to both of the spectrum areas studied, with a coefficient of determination for cross validation larger than 0.7 for most parameters studied. While the two spectroscopic methods gave almost identical results, FTIR indicated higher robustness for the prediction of tannin concentration. Conversely, UV-vis appeared to be more relevant when determining anthocyanin concentration and evolution. Finally, the models obtained when combining the two spectrum areas gave slightly better results. When a selection of different visible wavelengths were added to the FTIR spectrum, the results showed that the prediction of anthocyanin parameters improved considerably, thus highlighting the importance of the visible area when estimating these compounds.
Tutorial on EM Algorithm
Authors: Nguyen Loc
Published: October 2020

Maximum likelihood estimation (MLE) is a popular method for parameter estimation in both applied probability and statistics but MLE cannot solve the problem of incomplete data or hidden data because it is impossible to maximize likelihood function from hidden data. Expectation maximum (EM) algorithm is a powerful mathematical tool for solving this problem if there is a relationship between hidden data and observed data. Such hinting relationship is specified by a mapping from hidden data to observed data or by a joint probability between hidden data and observed data. In other words, the relationship helps us know hidden data by surveying observed data. The essential ideology of EM is to maximize the expectation of likelihood function over observed data based on the hinting relationship instead of maximizing directly the likelihood function of hidden data. Pioneers in EM algorithm proved its convergence. As a result, EM algorithm produces parameter estimators as well as MLE does. This tutorial aims to provide explanations of EM algorithm in order to help researchers comprehend it. Moreover some improvements of EM algorithm are also proposed in the tutorial such as combination of EM and third-order convergence Newton-Raphson process, combination of EM and gradient descent method, and combination of EM and particle swarm optimization (PSO) algorithm.
Influence of Amounts and Particle Diameter on the Mechanical Properties of Several Polymeric Composites Reinforced with GTR Particles
Authors: Marín Genescà Marc , García-Amorós Jordi , Mujal-Rosas Ramon , Massagués Lluís , Colom Xavier
Published: October 2020

Nowadays, the massive use of tires generates large stocks of waste material which is a serious environmental problem. The usual method used for processing wasted tires is mechanical crushing, in which fiber, steel, and rubber are separated. The aim of this research is the recycling of the obtained rubber, called also GTR (Ground Waste Tires). With this purpose, the paper analyses the mechanical properties of the composites produced by mixing GTR with several industrial polymers. These composites are characterized by the percentage of GTR in the composite and its particle size. These two variables along with seven industrial polymers define a set of composites from which the mechanical properties are analyzed and presented. From the results, it can be drawn that this proposal could be a way to enhance some polymer properties and to contribute in some way to reduce the environmental wasted tires problem.
Novel Mapping Methods to Describe Utilization of Free Breast Cancer Screening from a State Program
Authors: Hughes Kelly , Haynes David , Joseph Anne
Published: October 2020

The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) of Minnesota, “Sage”, provides breast cancer screening to uninsured women. We introduce a novel mapping technique, spatially adaptive filters (SAFs), to estimate utilization of Sage screening in Minnesota. Sage screenings (N = 74,712) were geocoded. The eligible population was modeled with the RTI synthetic population dataset. Between 2011 and 2015, 36,979 women a year were Sage eligible. Utilization was highly variable across Minnesota (M = 37.2%, range 0% - 131%, SD = 18.7%). This replicable approach modeled utilization rates to the neighborhood-level, allowing Sage to prioritize locations and engage communities.
Portfolio Risk Assessment under Dynamic (Equi)Correlation and Semi-Nonparametric Estimation: an Application to Cryptocurrencies
Authors: Jiménez Inés , Mora-Valencia Andrés , Ñíguez Trino-Manuel , Perote Javier
Published: October 2020

The semi-nonparametric (SNP) modeling of the return distribution has been proved to be a flexible and accurate methodology for portfolio risk management that allows two-step estimation of the dynamic conditional correlation (DCC) matrix. For this SNP-DCC model, we propose a stepwise procedure to compute pairwise conditional correlations under bivariate marginal SNP distributions, overcoming the curse of dimensionality. The procedure is compared to the assumption of Dynamic Equicorrelation (DECO), which is a parsimonious model when correlations among the assets are not significantly different but requires joint estimation of the multivariate SNP model. The risk assessment of both methodologies is tested for a portfolio on cryptocurrencies by implementing backtesting techniques and for different risk measures: Value-at-Risk, Expected Shortfall and Median Shortfall. The results support our proposal showing that the SNP-DCC model has better performance for a smaller confidence level than the SNP-DECO model, although both models perform similarly for higher confidence levels.
Antioxidant Properties of Lyophilized Rosemary and Sage Extract and its Effect to Prevent Lipid Oxidation In Poultry Pátê
Authors: Bianchin Mirelli , Pereira Daiane , Almeida Jacqueline Florio , Moura Cristiane , Pinheiro Rafaelly Simionatto , Heldt Leila Fernanda Serafini , Haminiuk Charles Windson Isidoro , Carpes Solange Teresinha
Published: October 2020

This study aimed to evaluate the antioxidant activities (AA) of lyophilized rosemary extract and lyophilized sage extract and their effects on the oxidative stability of poultry pátê. For this purpose, four poultry pátê formulations with rosemary, sage, sodium erythorbate, and a control (without antioxidants) were produced. The rosemary and sage were characterized according to total phenolic compounds (TPC), and AA by several methods. The poultry pátês stored at 4°C were evaluated by the lipid oxidation. High concentrations of TPC were detected in rosemary extract and sage extract (46.48 and 41.61 mg GAE/g: Gallic acid equivalent respectively). The AA of rosemary and sage extracts by free radical-scavenging were 4745.72 and 2462.82 µmol Trolox/g, respectively. The high concentration of catechin, rutin, myricetin and p-coumaric acids in these extracts may be responsible for the strong inhibitory action against food pathogens. Besides these compounds can be responsible for the best performance in inhibiting lipid oxidation in poultry pátês during the storage. This study suggests that rosemary and sage extracts may be used as a natural antioxidant in meat products.
Discovery of Eriodictyol as Putative Exportin-1 Inhibitor for Non-small Cell Lung Cancer Therapy
Authors: Adigun Temidayo Olamide , Joel Ireoluwa Yinka , Bankole Olukayode Olusola , Ambrose George Oche , Medayedupin Oluwatobi Ayodeji , Omoyeni Oluwatobi Cynthia , Agunlejika Adebimpe Ayomide , Ozojiofor Ugochukwu Okechukwu , Omoniyi Adedayo Pius , Fakolujo Idowu Yetunde
Published: October 2020

Exportin-1, the ubiquitous nuclear protein transporter, is widely confirmed as an active chemotherapeutic target in non-small cell lung cancer condition while Juglans mandshurica is a well-studied anticancer plant in some lung cancer cell lines. We intend to find novel exportin-1 inhibitor from Juglans mandshurica with better potential tolerability and pharmaco-dynamo-kinetic properties than the current selective inhibitors of nuclear export in non-small cell lung cancer treatment. Osiris property explorer DataWarrior, Glide standard precision docking, quantum mechanics polarized ligand docking, MMGBSA binding free energy calculations, Jaguar density functional theory analysis, and the online web-based SwissADME were employed respectively in this study to filter the retrieved compounds based on tolerability, toxicity, and Lipinsky’s rule of five violation potential, determine their druggability, establish relative stability of the lead compound in water solvation model, and evaluates druglikeness, lead-likeness, as well as synthetic accessibility of the lead compound. This study reveals eriodictyol as having higher binding free energy (-40 kcal/mol) than that of standard (-39.56 kcal/mol) in exportin-1 active site, better synthetic accessibility score (3.15 versus 3.29), high GI absorption, non-blood brain barrier permeant, lacks Brenk and PAINS alert, obeying Lipinski’s, Ghose’s, Veber’s, Egan’s, and Muegge’s rule of druglikeness and lead-likeness as well as non-cytotoxic to HepG2 cells. We therefore found eriodictyol as a lead-like, non-toxic exportin-1 inhibitor with good predictive stability and pharmacokinetic potential and thus provided data for further validation of eriodictyol as a candidate exportin-1 inhibitor in both preclinical and clinical studies involving lung cancer therapy.
Excretory system learning: What is the relationship between critical thinking skills and biology learning motivation?
Authors: Rizky Hanifia , Sukmawati Dalia , Rusdi R
Published: October 2020

This research aims to find out the relationship between critical thinking skills and students’ learning motivation in the excretory system content. The research employs a descriptive method with correlation approach. The research population includes students of Madrasah Tsanawiyah Negeri of a school in Jakarta Timur, Indonesia. Sampling is conducted using multi-stage sampling. Samples used are 95 students of Grade IX. The research instruments consist of critical thinking skill test and learning motivation questionnaire. Data analysis uses regression analysis technique. The regression equation is compiled and tested with variance analysis using ANOVA table with F-test. The multiple regression hypothesis testing carries out by compiling multiple regression equation and testing using variance analysis with t-test. The research results indicate pxy, means that there is a correlation between critical thinking and learning motivation. The research recommendation is that the excretory system learning activity empowers critical thinking so that it improves motivation to learn the excretory system.
Development, factorial structure and reliability of the Multidimensional Scale of Emotional Regulation for Adolescents (MSERA): Preliminary analysis
Authors: Rodriguez-Alcantara Raquel , Barcelata Blanca E.
Published: October 2020

The evaluation of emotion regulation has been focused on the cognitive component and the emotion dysregulation. However, it is also important to include emotion identification and modulation of the response for the evaluation of the regulatory process. The aim of this study was to develop a multidimensional measure of emotion regulation process in adolescents and to examine its factorial structure and reliability. An instrumental study was performed with 887 Mexican adolescents aged 13 to 18. A preliminary version of the Multidimensional Scale of Emotion Regulation for Adolescents (MSERA) was developed based on focus groups and considering the assumptions of the theoretical models. The exploratory factor analysis yielded 56 items distributed in eight factors: Recognition of positive emotions, Expression of positive emotions, Emotional control, Suppression, Cognitive change, Physical reactions, Recognition of negative emotions and Difficulty to regulate. A confirmatory factor analysis using the Robust Unweighted Least Squares, corroborated the initial solution of eight factors and showed acceptable fit indexes, considering 47 items. Ordinal alpha coefficients obtained for the factors of the final model, indicated a good internal consistency (.85-.95). Results suggest that the MSERA can be used as a valid and reliable measure of emotion regulation in adolescents.
Funcionamiento familiar en adolescentes en riesgo de suicidio con rasgos de personalidad límite: un estudio exploratorio
Authors: Marco-Sánchez Sara , Mayoral-Aragón María
Published: October 2020

La alta prevalencia de suicidio en población adolescente en todo el mundo supone un reto mundial en salud mental. El ambiente familiar ha sido señalado como una importante variable implicada en el riesgo de suicidio de los adolescentes, ejerciendo tanto de factor de riesgo como protector. El estudio tiene como objetivo entender qué variables del funcionamiento familiar de la Escala de Clima Social en la Familia se relacionan con la puntuación de la Escala de Ideación Suicida de Beck en una muestra 37 adolescentes entre 14 y 18 años (M = 15.76; DT = 1.07) con rasgos de personalidad límite. Se partió de la hipótesis de que peores niveles de funcionamiento familiar aumentarían el riesgo de suicidio. Los resultados mostraron que la ideación suicida era mayor cuando las puntuaciones en la escala Relaciones (calidad de la comunicación e interacción) en la familia eran menores. Al analizar cada escala, se demostró la importancia específica de la subescala Expresividad, referida al grado de expresión libre de los sentimientos en la familia de forma que, a menor expresividad en la familia, mayor ideación suicida presentaban los adolescentes, y la subescala Social-Recreativa, referida a la participación social y en actividades de ocio de la familia, de modo que a mayor participación social, menor riesgo suicida. Estos resultados son apoyados por otros estudios que demuestran la importancia de modificar el entorno familiar para influir en el riesgo suicida de los adolescentes. El valor de estos datos implica la consideración de incluir a las familias en los programas de tratamiento para adolescentes suicidas.
La apreciación del grafiti como arte urbano. El caso del Graffiti Fest en Puerto Vallarta
Authors: Patiño-García Camilo , Belmonte-Castillo Montserrat Alejandra
Published: October 2020

El grafiti como arte urbano es un concepto difícil de encasillar, desde su concepción como un constructo cultural, hasta su categorización, dada su heterogeneidad de creación. Sin embargo, estas obras transitorias tienen una representación en la sociedad que interpreta y valora su mensaje, a su vez que lo dignifica como arte. El presente trabajo examina la relación entre el arte urbano creado en Puerto Vallarta, en específico las intervenciones realizadas en el evento Graffiti Fest, con la percepción y la apreciación de la comunidad habitante de los espacios en los que se plasmaron las obras. A partir de una definición abierta del arte se investiga la institucionalización, la representación y el reconocimiento de las obras por parte de la comunidad. El artículo plantea una revisión conceptual sobre el arte urbano y el grafiti para establecer su valor como arte en relación con su contexto y apropiación. Se estudia el Graffiti Fest por medio de entrevistas a los autores, con el propósito de identificar su actividad como una forma de expresión y divulgación artística que busca acercar el grafiti en cuanto forma de arte a la sociedad. Además, se analiza la apropiación de la comunidad, por medio de una entrevista aplicada a la población, a fin de determinar su concepción del grafiti como arte y la valoración de las obras realizadas. Los resultados muestran que la identificación como forma de arte de las obras es resultado de su institucionalización y vinculación con el muralismo callejero y el grafiti artístico.
Evaluation the efficacy and safety of fire needle compared to filiform needle on knee osteoarthritis: study protocol for a randomised controlled trial
Authors: Gao Yuanjie , Liu Lu , Li Bin , Guo Jing , Liu Huilin , Wang Shaosong , Zhang Fan , Ji Xu , Fu Yuanbo , Wang Yizhan , Sun Jingqing , Yuan Fang
Published: October 2020

Background: Knee osteoarthritis is a common clinical chronic degenerative disease associated with high morbidity and long-term disability. Previous studies have confirmed the efficacy of acupuncture on knee osteoarthritis. Fire needle acupuncture is a combination of heat and acupuncture, which may be more effective than the commonly used filiform needle acupuncture. This study is designed as a randomized controlled trial to evaluate the efficacy and safety of fire needle acupuncture compared to filiform needle acupuncture in knee osteoarthritis patients.Methods and analysis: This is a prospective randomized controlled superiority clinical trial to evaluate the efficacy and safety of fire needle acupuncture compared to filiform needle acupuncture for knee osteoarthritis. A total of 100 participants will be randomly assigned to two different groups. Participants will receive fire-needle acupuncture treatment in the fire needle group, while participants in the filiform needle group will be treated with a filiform needle at the same acupuncture points as the fire needle group. All participants will receive a 6-weeks of treatment (2 times per week). The primary outcome is the change of the Western Ontario and McMaster Universities Osteoarthritis Index, and the secondary outcomes include the change of the Visual Analogue Scale, and 12-item Short Form Health Survey from baseline to endpoint. Ethics and dissemination: Ethical approval of this study was granted by the Research Ethical Committee of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University (2018SB-066). Written informed consent will be obtained from all participants. Outcomes of the trial will be disseminated through peer-reviewed publications.Trial registration: The trial is registered on Dec. 20, 2018, and the registration number is ChiCTR1800019579.
Increased Vδ1γδT cells Predominantly Contributed to IL-17 Production in the Development of Adult Human Post-infectious Irritable Bowel Syndrome
Authors: dong liwei , sun xiaoning , ma zhichao , fu jiao , liu fujin , huang baili , liang dongchun , sun deming , lan cheng
Published: October 2020

Background: γδT cells play an important role in the mucosa inflammation and immunity-associated disorders. Our previous study reported that γδT cells producing IL-17 were involved in the pathogenesis of post-infectious irritable bowel syndrome (PI-IBS). However, their subset characteristic profile in this kind of disease remains unclear. Thus the current study’s aim is to investigate the functionally predominant subset and its role in PI-IBS. Methods: The total T cells were collected from the peripheral blood of patients with PI-IBS. The peripheral proportion of Vδ1 and Vδ2 subset was detected by FACS after stained with anti δ1-PE and anti δ2-APC. The local colonic proportion of this two subsets were measured under laser confocal fluorescence microscope. Vδ1 γδ T cells were enriched from the total peripheral T cells by minoantibody-immuno-microbeads (MACS) method. and cultured, functionally evaluated by CCK-8 assay (proliferation)，CD69/CD62L molecules expression assay (activation) and ELISA (IL-17 production) respectively.Results: 1. Vδ1 γδ T cells significantly increased while Vδ2 γδ T cells remained unchanged in both the peripheral blood and local colonic tissue from PI-IBS patients (P<0.05). 2. When cultured in vitro, the Vδ1 γδ T cells remarkably proliferated, activated and produced IL-17 (P<0.05). Conclusions: Our results suggest that Vδ1 γδ T cells was the predominant γδ T cells subset in both peripheral and intestinal tissue, and was the major IL-17 producing γδ T cells in PI-IBS.
Retrospective cohort study of nanoparticle albumin-bound paclitaxel plus ramucirumab versus paclitaxel plus ramucirumab as second-line treatment in patients with advanced gastric cancer
Authors: Okunaka Mashiro , Kotani Daisuke , Demachi Ken , Kawazoe Akihito , Yoshino Takayuki , Kawasaki Toshikatsu , Shitara Kohei
Published: October 2020

Background: Nanoparticle albumin-bound paclitaxel (nab-PTX) has shown non-inferiority to paclitaxel (PTX) as second-line therapy for advanced gastric cancer (AGC) with fewer infusion-related reactions. The efficacy and safety of nab-PTX plus ramucirumab (RAM) was reported in a phase II trial; however, there is no randomized trial comparing this regimen with PTX plus RAM in patients with AGC. This retrospective study aimed to investigate the efficacy and safety of nab-PTX plus RAM versus PTX plus RAM in patients with AGC.Methods: This study included patients with AGC who received nab-PTX plus RAM from September 2017 to January 2019 or PTX plus RAM from June 2015 to August 2017 as second-line chemotherapy in our hospital.Results: A total of 113 and 138 patients who received nab-PTX plus RAM and PTX plus RAM, respectively, were analyzed. Median progression-free survival (PFS) was 3.9 months (95% confidence interval [CI]: 3.4–4.3) in the nab-PTX plus RAM group and 3.9 months (95% CI: 3.1–4.7) in the PTX plus RAM group (hazard ratio [HR]: 1.08; 95% CI: 0.83–1.40; P = 0.573). Median overall survival (OS) was 10.9 months (95% CI: 9.3–12.7) in the nab-PTX plus RAM group and 10.3 months (95% CI: 8.5–12.0) in the PTX plus RAM group (hazard ratio: 0.82; 95% CI: 0.61–1.10; P = 0.188). In patients with moderate/massive ascites, favorable outcomes for progression-free survival were observed in the nab-PTX plus RAM group compared with the PTX plus RAM group. Although anemia and fatigue (any grade) were more frequent in the nab-PTX plus RAM group, discontinuation of study treatment was not increased in the nab-PTX plus RAM group. There was no occurrence of hypersensitivity reaction in the nab-PTX plus RAM group, while two patients (1.4%) experienced grade 3 hypersensitivity reactions in the PTX plus RAM group.Conclusions: The combination of nab-PTX plus RAM showed a similar efficacy and safety profile to PTX plus RAM as second-line treatment for patients with AGC.
Health anxiety and related factors among pregnant women during the COVID-19 pandemic: a cross-sectional study from Iran
Authors: Saadati Najmieh , Afshari Poorandokht , Boostani Hatam , Beheshtinasab Maryam , Abedi Parvin , Maraghi Elham
Published: October 2020

Background: The pandemic of COVID-19 affected many countries as well as Iran. The aim of this study was to evaluate the health anxiety of the Iranian pregnant women in time of the pandemic of the COVID-19. Methods: In this cross-sectional study 300 pregnant women in different trimesters (n=100 in each trimester) were recruited. A demographic questionnaire and the Health Anxiety questionnaire were used to collect data. Because of quarantine data were collected through social media groups. The chi-square, ANOVA and multiple linear regression were used to analyze data. Results: The total score of anxiety was 22.3±9.5, 24.6±9.3 and 25.4±10.6 in the first, second and third trimester of pregnancy. In total, 9%, 13% and 21% of the women had severe anxiety or scores≥35 in the first, second and third trimester of pregnancy respectively. Pregnant women in the third trimester significantly had more health anxiety score and higher scores of “total health anxiety” than the first trimester ones(p=0.045). Conclusion: At the time of the pandemic of COVID-19, women in the second and third trimester of pregnancy were more worry about consequences of disease, but the total score of health anxiety was significantly more in the women in the third trimester of pregnancy. Health care providers should pay more attention to the mental health of pregnant women in times of crises such as Corona pandemic.
Structure and trends of international sport nutrition research between 2000-2018: bibliometric mapping of sport nutrition science
Authors: Kiss Anna , Temesi Ágoston , Tompa Orsolya , Lakner Zoltán , Soós Sándor
Published: October 2020

Background: The tool kits of bibliometrics and science mapping provide a standard methodology to map the knowledge base of specific fields of science. The aim of the present research is the analysis of the recent international trends of sport nutrition science, as well as the primary identification of the research topics and results of sport nutrition science via enhanced bibliometric methods for the 2000-2018 time period. Methods: Altogether, 3889 publications were included in this study. We identified the most relevant sport nutrition topics by running a community detection algorithm on the proximity network constructed via network text analysis. The key issues and key concepts of sport nutrition topics as well as their relations were evaluated via network analysis. We also carried a chronological analysis of topics out, and a scientometric evaluative analysis was also created. Results: We identified the four main basic groups from which the 18 most characteristics topics were analyzed. The 18 topics are the following: soccer and physiology, carbohydrate metabolism, muscle physiology: alkalosis and acidosis, muscle mass gain and dietary supplementation, fluid balance and hydration, dietary intake and nutrition knowledge, determination of energy need of athletes, bone health and female athlete triad, hydration strategy, body weight management, nutritional strategies and human skeletal muscle, dietary supplementation of nitrates, oxidative stress and dietary supplement use, dietary supplement use and doping, oxidative stress and inflammation and dietary antioxidants, exercise adaptation and nutritional strategies, gut microbiota, celiac disease. Based on the size of the topic, research on sport nutrition science has put the biggest emphasis on the following three groups: muscle mass gain and dietary supplementation, carbohydrate metabolism, oxidative stress and dietary supplement use. The greatest scientific impact can be ascribed to the following topics: nutritional strategies and human skeletal muscle, dietary supplementation of nitrates, body weight management, and gut microbiota. Conclusions: Scientific output on sport nutrition has continuously been rising between 2000-2018. The ratio of topics related to sport nutrition but first of all connected to basic research has decreased significantly within all publications. The results of this study confirm the role of science mapping in the identification of specific research topics and primary research directions in the field of sport nutrition science.
Yield and yield-reduction in recent drought years in southern Tigray, northern Ethiopia: Implications on food security
Authors: Eze Emmanuel , Girma Atkilt , Zenebe Amanuel , Okolo Chukwuebuka Christopher , Negash Emnet
Published: October 2020

The consequences of prolonged precipitation-deficient periods are primarily substantial water deficit, with the spatial characteristics of drylands and various socioeconomic factors worsening its impacts and deepening poverty among agrarian communities, with attendant food security implications. This study utilizes a combination of climate, remote sensing and field survey data. These data were used to obtain a first-hand information on the impacts of recent (2015 and 2017) droughts on crop yield in southern Tigray, northern Ethiopia. Annual and seasonal rainfall, annual and seasonal NDVI and Dev-NDVI, and monthly SPI-1, SPI-3 and SPI-12 (for June to October) were considered as likely factors that could relate with yield and yield loss in the area. Correlation and multiple linear stepwise regression statistical techniques were used to determine drought-yield relationships, and identify more accurate predictors of yield and yield losses in each of the drought years. The area witnessed a more widespread precipitation deficit in 2015 than in 2017, where the lowland area recorded entire crop losses. Also, droughts manifested spatiotemporal variations and impacts across the 3 different agroecologies – primarily reduction in vegetation amounts, coinciding with the planting and maturing stages of crops. Crop failures therefore translated to food shortages and reduced income of smallholders, which denotes food insecurity in the time of droughts. Seasonal rainfall and June Dev-NDVI predicted 66.9% of 2015 yield loss, while NDVI predicted 2017 sorghum yield by 96%. Spate irrigation should be further popularized in the low-lying areas of Raya Azebo to augment for future deficiencies in the kiremt rainfall.
Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and genome-wide genetic interaction analysis in UK Biobank cohort
Authors: Liang Xiao , Cheng ShiQiang , Ye Jing , Chu XiaoMeng , Wen Yan , Liu Li , Qi Xin , Jia YuMeng , Zhang Feng
Published: October 2020

Objective: To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.Methods: The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, genome-wide genetic interaction study (GWGIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.Results: We observed positive association between SHBG and the frequency of alcohol consumption (b=0.0101, p=3.84×10–11) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b=0.0128, p=1,96×10–8) in middle-aged males. Moreover, SHBG was associated with the frequency of alcohol consumption (b=0.0067, p=2.60×10–3) in middle-aged females. Finally, GWGIS identified one significant loci, Tenascin R (TNR) (rs34633780, p=3.45×10–8) interacting with total testosterone for fluid intelligence.Conclusion: Our study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.
The Effects of Everyday-life Exposure to Polycyclic Aromatic Hydrocarbons on Biological Age Indicators
Authors: Pavanello Sofia , Campisi Manuela , Mastrangelo Giuseppe , Hoxha Mirjam , Bollati Valentina
Published: October 2020

Background Further knowledge on modifiable aging risk factors is required to mitigate the increasing burden of age-related diseases in a rapidly growing global demographic of elderly individuals. We explored the effect of everyday exposure to polycyclic aromatic hydrocarbons (PAHs), which are fundamental constituents of air pollution, on cellular biological aging. This was determined via the analysis of leukocyte telomere length (LTL), mitochondrial DNA copy number (LmtDNAcn), and by the formation of anti- benzo[a]pyrene diolepoxide (B[a]PDE–DNA) adducts.Methods The study population consisted of 585 individuals living in North-East Italy. PAH exposure (diet, indoor activities, outdoor activities, traffic, and residential exposure) and smoking behavior were assessed by questionnaire and anti-B[a]PDE–DNA] by high-perfomance-liquid-chromatography. LTL, LmtDNAcn and genetic polymorphisms [glutathione S-transferase M1 and T1 (GSTM1; GSTT1)] were measured by polymerase chain reaction. Structural equation modelling analysis evaluated these complex relationships.Results Anti-B[a]PDE–DNA enhanced with PAH exposure (p=0.005) and active smoking (p=0.0001), whereas decreased with detoxifying GSTM1 (p=0.021) and in female (p=0.0001). Subsequently, LTL and LmtDNAcn reduced with anti-B[a]PDE–DNA (p=0.028 and p=0.018), particularly in males (p=0.006 and p=0.0001). Only LTL shortened with age (p=0.001) while elongated with active smoking (p =0.0001). Besides this, the most significant determinants of PAH exposure that raised anti-B[a]PDE–DNA were indoor and diet (p=0.0001 ), the least was outdoor (p=0.003). Conclusion New findings stemming from our study suggest that certain preventable everyday life exposures to PAHs reduce LTL and LmtDNAcn. In particular, the clear association with indoor activities, diet, and gender opens new perspectives for tailored preventive measures in age-related diseases.Capsule Everyday life exposure to polycyclic aromatic hydrocarbons reduces leukocyte telomere length and mitochondrial DNA copy number through anti-B[a]PDE-DNA adduct formation.