bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of synthetic consortia from a set of plant‐beneficial bacteria
Authors: Wang Yixu , Dall'Agnol Rebeca Fuzinatto , Bertani Iris , Bez Cristina , Venturi Vittorio
Published: January 2024

The use of microbial inoculants in agriculture as biofertilisers and/or biopesticides is an appealing alternative to replace or reduce the practice of agrochemicals. Plant microbiota studies are revealing the different bacterial groups which are populating plant microbiomes re‐energising the plant probiotic bacteria (PPB) translational research sector. Some single‐microbial strain bioinoculants have proven valid in agriculture (e.g., based on Trichoderma, mycorrhiza or rhizobia); however, it is now recommended to consider multistrain consortia since plant‐beneficial effects are often a result of community‐level interactions in plant microbiomes. A limiting step is the selection of a fitting combination of microbial strains in order to accomplish the best beneficial effect upon plant inoculation. In this study, we have used a subset of 23 previously identified and characterised rice‐beneficial bacterial colonisers to design and test a series of associated experiments aimed to identify potential PPB consortia which are able to co‐colonise and induce plant growth promotion. Bacterial strains were co‐inoculated in vitro and in planta using several different methods and their co‐colonisation and co‐persistence monitored. Results include the identification of two 5‐strain and one 2‐strain consortia which displayed plant growth‐promoting features. Future practical applications of microbiome research must include experiments aimed at identifying consortia of bacteria which can be most effective as crop amendments.
Gilteritinib in combination with venetoclax, low‐dose cytarabine and actinomycin D for relapsed or refractory FLT3‐mutated acute myeloid leukaemia
Authors: Zucenka Andrius , Griskevicius Laimonas
Published: January 2024

We have conducted a retrospective, single‐centre analysis of 20 patients with relapsed or refractory FLT3‐mutated acute myeloid leukaemia (FLT3m AML) who received a salvage quadruplet regimen consisting of gilteritinib, venetoclax, low‐dose cytarabine and actinomycin D (G‐ACTIVE). G‐ACTIVE resulted in a 95% (19/20) overall response rate and 75% (15/20) complete remission and complete remission with an incomplete platelet recovery (CR + CRp) rate. Out of 13 transplant‐eligible patients, 11 (86%) proceeded to an allogeneic stem cell transplantation. The median overall survival and relapse‐free survival after G‐ACTIVE were 32 and 12.9 months respectively. The Day 60 mortality rate was 15%.
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury
Authors: Byington Caroline G. , Goodman Adam M. , Allendorfer Jane B. , Correia Stephen , LaFrance W. Curt , Szaflarski Jerzy P.
Published: January 2024

Objective

The uncinate fasciculus (UF) has been implicated previously in contributing to the pathophysiology of functional (nonepileptic) seizures (FS). FS are frequently preceded by adverse life events (ALEs) and present with comorbid psychiatric symptoms, yet neurobiological correlates of these factors remain unclear. To address this gap, using advanced diffusion magnetic resonance imaging (dMRI), UF tracts in a large cohort of patients with FS and pre‐existing traumatic brain injury (TBI + FS) were compared to those in patients with TBI without FS (TBI‐only). We hypothesized that dMRI measures in UF structural connectivity would reveal UF differences when controlling for TBI status. Partial correlation tests assessed the potential relationships with psychiatric symptom severity measures.

Methods

Participants with TBI‐only (N = 46) and TBI + FS (N = 55) completed a series of symptom questionnaires and MRI scanning. Deterministic tractography via diffusion spectrum imaging (DSI) was implemented in DSI studio (https://dsi‐studio.labsolver.org) with q‐space diffeomorphic reconstruction (QSDR), streamline production, and manual segmentation to assess bilateral UF integrity. Fractional anisotropy (FA), radial diffusivity (RD), streamline counts, and their respective asymmetry indices (AIs) served as estimates of white matter integrity.

Results

Compared to TBI‐only, TBI + FS participants demonstrated decreased left hemisphere FA and RD asymmetry index (AI) for UF tracts (both p < .05, false discovery rate [FDR] corrected). Additionally, TBI + FS reported higher symptom severity in depression, anxiety, and PTSD measures (all p < .01). Correlation tests comparing UF white matter integrity differences to psychiatric symptom severity failed to reach criteria for significance (all p > .05, FDR corrected).

Significance

In a large, well‐characterized sample, participants with FS had decreased white matter health after controlling for the history of TBI. Planned follow‐up analysis found no evidence to suggest that UF connectivity measures are a feature of group differences in mood or anxiety comorbidities for FS. These findings suggest that frontolimbic structural connectivity may play a role in FS symptomology, after accounting for prior ALEs and comorbid psychopathology severity.
Switchgrass (Panicum virgatum L.) cultivars have similar impacts on soil carbon and nitrogen stocks and microbial function
Authors: Mosier Samantha , Kelly Lauren , Ozlu Ekrem , Robertson G. Philip
Published: January 2024

Switchgrass (Panicum virgatum L.) production for biofuel has the potential to produce reasonable yields on lands not suited for conventional agriculture. We assessed nine switchgrass cultivars representing lowland and upland ecotypes grown for 11 years at a site in the upper Midwest USA for belowground differences in soil carbon and nitrogen stocks, soil organic matter fractions, and standing root biomass to 1 m depth. We also compared potential nitrogen mineralization and carbon substrate use through community‐level physiological profiling in surface soils (0–10 cm depth). Average yields and standing root biomass differed among cultivars and between ecotypes, but we found no significant cultivar‐related impacts on soil carbon and nitrogen stocks, on the distribution of particulate and mineral‐associated soil organic matter fractions, nor on potential nitrogen mineralization or microbial community‐level physiological profiles. That these traits did not differ among cultivars suggests that soil carbon and nitrogen gains under switchgrass are likely to be robust with respect to cultivar differences, and to this point not much affected by breeding efforts.
Improved oxidation resistance while maintaining slag corrosion resistance of MgO–SiC–C refractories with moderate amounts of liquid phase
Authors: Guo Weijie , Zhao Xu , Zhu Tianbin , Chen Qilong , Li Yawei , Xu Xiaofeng , Xu Yibiao , Dai Yajie , Yan Wen , Li Yuanjin , Wang Xuyuan
Published: January 2024

MgO–SiC–C refractories with superior hot strength, oxidation resistance and slag resistance have potential to become substitute refractories for matte smelting furnace. In the present work, the influence of glass powder addition on phase compositions, hot strength, oxidation resistance, and slag resistance of MgO–SiC–C refractories was investigated. The liquid phase introduced by glass powder filled the pores, blocking the channel for the ingress of the oxygen and thus improving the oxidation resistance. Although the oxidation resistance of such refractories was improved with 1–3 wt% glass powder addition, their hot strength and slag corrosion resistance decreased when the glass powder content was 2–3 wt%. To balance the mechanical properties, oxidation resistance and slag resistance, low amount glass powder addition (1 wt%) was considered better choice.
Stress‐induced multiferroic properties of lead‐free (1 − x)BTNO–(x)CFO nanocomposites
Authors: Arshad M. , Khan Wasi , Abushad M. , Nadeem M. , Riyaz  , Husain Shahid , Shukla D. K. , Ansari Azizurrahaman , Chakradhary Vishal Kumar , Khan Shakeel
Published: January 2024

Multiferroic composites of (1 − x)BaTi0.98Ni0.02O3–(x)CoFe2O4 (0 ≤ x ≤ 0.06) were prepared through conventional solid‐state reaction route. X‐ray diffraction (XRD) studies along with the Rietveld refinement endorse the multiphase nature of the nanocomposite samples. The XRD peaks of the tetragonal bare barium titanate and the inverse cubic spinel of cobalt ferrite nanostructures phase can be identified separately. The tetragonality ratio of the bare barium titanate drops with the addition of the guest material, i.e., cobalt ferrite in the ferroelectric matrix. The Fourier transform infrared (FTIR) spectra confirm the main absorption bands near 540–560 cm−1, corresponding to the metal‐oxide absorption band (ν1 mode), and are related to the stretching modes of the Ti–O bonds. The Raman spectra also signify the two symmetries confirming the nanocomposites’ ferroelectric and ferromagnetic phases. The surface morphology studies reveal the hexagonal and spherical shape of the grains in the nanostructures and nanocomposites. The energy‐dispersive x‐ray spectroscopy (EDX) spectra confirm the presence of all the elements in the samples. The ferroelectricity in the nanocomposite drops due to fluctuations in the valence state of Fe2+/Fe3+ that enhances the leakage current of the nanocomposites. The magnetic moment and dielectric constant of the nanocomposites are enhanced as the guest compound CoFe2O4 is added to the bare BaTi0.98Ni0.02O3. Thus, the simultaneous coexistence of ferroelectric and magnetic ordering at room temperature confirms the multiferroic behavior of the nanostructure and the nanocomposites.
Kinetics and mechanism of (re)hydroxylation in fired clay minerals
Authors: Kuligiewicz Artur , Derkowski Arkadiusz
Published: January 2024

Three types of smectite with various crystallochemical compositions and interlayer cations as well as kaolinite and illite were fired at 800°C and 650°C and tested for their rehydroxylation's (RHX) potential and kinetics in the presence of water vapor at 200°C–350°C. A dehydroxylated structure of 2:1 Al‐rich mineral with the interlayer pillared by a large cation (like K+ or Cs+) is wide enough to allow H2O diffusion which results in advanced RHX, that is, restoring up to several tens of percent of the original OH content. Such 2:1 layer structures (beidellite, illite) do not follow the time‐to‐the‐quarter (TTTQ) kinetics during RHX and show a non‐Arrhenius behavior for isothermal RHX. Because TTTQ kinetics is assumed in an RHX dating of ceramic artifacts in archaeometry, fired‐clay ceramics prepared from material dominated by Al‐rich 2:1 minerals was found unfeasible for RHX dating.

Kaolinite and Mg2+‐ or Ca2+‐exchanged smectites show the Arrhenius behavior and follow the TTTQ kinetics of RHX, resulting in apparent Ea increase with the progress of reaction (up to α ∼0.2) of ∼20–50 kJ/mol in beidellite and 15–35 kJ/mol in montmorillonite. We suggest using ‘hydroxylation’ rather than ‘rehydroxylation’ for structurally‐disordered fired clays gaining OH groups in an unknown position.
Efficacy of topical gabapentin in women with primary macular amyloidosis: A side‐by‐side triple‐blinded randomized clinical trial
Authors: Abtahi‐Naeini Bahareh , Hemati Elahe , Faghihi Gita , Shahmoradi Zabihollah , Paknazar Fatemeh , Rastegarnasab Fereshte , Varshosaz Jaleh , Hadian Mahdi , Akbari Mojtaba , Sabzghabaee Ali Mohammad
Published: January 2024

Background

Primary cutaneous macular amyloidosis (PCMA) is a chronic pruritic cutaneous disease characterized by heterogeneous extracellular deposition of amyloid protein in the skin.

Aims

This study aimed to evaluate the efficacy of topical 6% gabapentin cream for the treatment of patients with PCMA.

Materials and Methods

In this triple‐blind clinical trial, a total of 34 patients, who were diagnosed with PCMA, treated using two different strategies of topical gabapentin as the active group and vehicle cream as the control group.

Results

Pruritus score reduction in both groups was statistically significant compared with the baseline value (p < 0.001). There was a significant pigmentation score reduction in intervention group compared with control group after 1 month of the study (p < 0.001). The differences of pigmentation score changes between the groups were not significant at month 2 (p = 0.52) and month 3 (p = 0.22).

Conclusions

The results of this study suggest that topical gabapentin cream may be effective as a topical agent in the treatment of pruritus associated with PCMA without any significant adverse effects. It is recommended to perform similar studies with a larger sample size and longer duration in both sexes.
Implementation of triple‐scan protocol to evaluate the fit of complete‐arch implant‐supported fixed prostheses
Authors: Borga Donmez Mustafa , Çakmak Gülce , Schimmel Martin , Yilmaz Burak
Published: January 2024

Passive fit is essential for multiple‐unit implant‐supported prostheses. Conventional methods to assess the passivity of complete‐arch implant‐supported prostheses do not allow 3‐dimensional (3D) visualization and quantification of misfit. This report describes the marginal and internal fit evaluation of a complete‐arch implant‐supported prosthesis by using the triple‐scan protocol involving a scanner and a 3D analysis freeware. This technique allows researchers, clinicians, or dental technicians to detect and quantify 3D prosthetic misfit, which may facilitate the preparation for dental appointments and objective measurement of misfit for research studies.
Use of a leadless pacemaker in the management of swallow syncope: A case report
Authors: Brieger Daniel G. , Tofler Geoffrey , Chia Karin K. M.
Published: January 2024

A 41‐year‐old male presented with syncope whilst eating and was subsequently demonstrated to have recurrent symptomatic sinus pauses whilst swallowing. Following the exclusion of structural heart disease, he was diagnosed with swallow syncope, an uncommon variant of neurocardiogenic syncope. To avoid long‐term complications of a transvenous pacemaker, the case was managed with a leadless pacemaker which resulted in complete resolution of symptoms.
Evaluation of parity and its interaction effect with season of calving, period of calving on production and reproduction traits in Hardhenu (Bos taurus × Bos indicus) dairy cattle
Authors: Pushpa   , Magotra Ankit , Sindhu Vikas , Chaudhary Pradeep
Published: January 2024

This study investigated the impact of parity, period of calving, and season of calving on various production and reproduction traits in Hardhenu cattle. Third‐parity cows outperformed first and second‐parity cows, exhibiting significantly higher total milk yield (TMY), 305 days milk yield (305d MY), peak yield (PY), and artificial insemination per conception (AIPC) (p < .01). The Lactation length (LL) was inversely related to parity, with first‐parity cows having extended lactations (p < .05). The period of calving had a substantial influence on production traits. The season of calving was critical, affecting production traits differently across parities. First‐parity cows had the highest TMY and 305d MY during winter and summer calving, with summer calving associated with shorter LL (p < .05). Second‐parity cows showed higher TMY and 305d MY during summer calving, while third‐parity cows had higher TMY in winter (p < .01). PY followed similar patterns to TMY, with LL affected by the season of calving. Additionally, the study explored interactions between parity, period of calving, and season of calving on reproduction traits. Third‐parity cows had higher AIPC compared to first and second‐parity cows (p < .01). Reproduction traits were also significantly affected by the period of calving, with cows calving in the 2017–2021 period displaying longer service period (SP), calving interval (CI), dry period (DP), and AIPC (p < .01). These findings highlight the complex interplay of biological, environmental, and management factors in shaping the productivity and reproductive efficiency of Hardhenu cattle, emphasizing the need for multifaceted considerations to optimize herd performance.
Spontaneous slow wave oscillations in extracellular field potential recordings reflect the alternating dominance of excitation and inhibition
Authors: Zheng Ying , Kang Sungmin , O'Neill Joseph , Bojak Ingo
Published: January 2024

In the resting state, cortical neurons can fire action potentials spontaneously but synchronously (Up state), followed by a quiescent period (Down state) before the cycle repeats. Extracellular recordings in the infragranular layer of cortex with a micro‐electrode display a negative deflection (depth‐negative) during Up states and a positive deflection (depth‐positive) during Down states. The resulting slow wave oscillation (SWO) has been studied extensively during sleep and under anaesthesia. However, recent research on the balanced nature of synaptic excitation and inhibition has highlighted our limited understanding of its genesis. Specifically, are excitation and inhibition balanced during SWOs? We analyse spontaneous local field potentials (LFPs) during SWOs recorded from anaesthetised rats via a multi‐channel laminar micro‐electrode and show that the Down state consists of two distinct synaptic states: a Dynamic Down state associated with depth‐positive LFPs and a prominent dipole in the extracellular field, and a Static Down state with negligible () LFPs and a lack of dipoles extracellularly. We demonstrate that depth‐negative and ‐positive LFPs are generated by a shift in the balance of synaptic excitation and inhibition from excitation dominance (depth‐negative) to inhibition dominance (depth‐positive) in the infragranular layer neurons. Thus, although excitation and inhibition co‐tune overall, differences in their timing lead to an alternation of dominance, manifesting as SWOs. We further show that Up state initiation is significantly faster if the preceding Down state is dynamic rather than static. Our findings provide a coherent picture of the dependence of SWOs on synaptic activity.

image

Key points

Cortical neurons can exhibit repeated cycles of spontaneous activity interleaved with periods of relative silence, a phenomenon known as ‘slow wave oscillation’ (SWO).

During SWOs, recordings of local field potentials (LFPs) in the neocortex show depth‐negative deflection during the active period (Up state) and depth‐positive deflection during the silent period (Down state).

Here we further classified the Down state into a dynamic phase and a static phase based on a novel method of classification and revealed non‐random, stereotypical sequences of the three states occurring with significantly different transitional kinetics.

Our results suggest that the positive and negative deflections in the LFP reflect the shift of the instantaneous balance between excitatory and inhibitory synaptic activity of the local cortical neurons.

The differences in transitional kinetics may imply distinct synaptic mechanisms for Up state initiation.

The study may provide a new approach for investigating spontaneous brain rhythms.
Multidisciplinary Robust Design Optimization Incorporating Extreme Scenario in Sparse Samples
Authors: Li Wei , Niu Yuzhen , Huang Haihong , Garg Akhil , Gao Liang
Published: January 2024

Robust design optimization (RDO) is a potent methodology that ensures stable performance in designed products during their operational phase. However, there remains a scarcity of robust design optimization methods that account for the intricacies of multidisciplinary coupling. In this article, we propose a multidisciplinary robust design optimization (MRDO) framework for physical systems under sparse samples containing the extreme scenario. The collaboration model is used to select samples that comply with multidisciplinary feasibility, avoiding time-consuming multidisciplinary decoupling analyses. To assess the robustness of sparse samples containing the extreme scenario, linear moment estimation is employed as the evaluation metric. The comparative analysis of MRDO results is conducted across various sample sizes, with and without the presence of the extreme scenario. The effectiveness and reliability of the proposed method are demonstrated through a mathematical case, a conceptual aircraft sizing design, and an energy efficiency optimization of a hobbing machine tool.
Integrating the gut microbiome and pharmacology
Authors: Verdegaal Andrew A. , Goodman Andrew L.
Published: January 2024

The gut microbiome harbors trillions of organisms that contribute to human health and disease. These bacteria can also affect the properties of medical drugs used to treat these diseases, and drugs, in turn, can reshape the microbiome. Research addressing interdependent microbiome-host-drug interactions thus has broad impact. In this Review, we discuss these interactions from the perspective of drug bioavailability, absorption, metabolism, excretion, toxicity, and drug-mediated microbiome modulation. We survey approaches that aim to uncover the mechanisms underlying these effects and opportunities to translate this knowledge into new strategies to improve the development, administration, and monitoring of medical drugs.
Complete genome sequence of enterococcal phage G01
Authors: Sheriff Emma K. , Andersen Shelby E. , Chatterjee Anushila , Duerkop Breck A.
Published: January 2024

Here, we report the annotated genome of enterococcal phage G01. The G01 genome is 41,189 bp in length and contains 67 predicted open reading frames. Host range analysis revealed G01 can infect 28.6% (6/21) of
Enterococcus faecalis
strains tested and appears to not require the enterococcal phage infection protein PIP
EF
.
A Novel Algorithm for Solving High-Dimensional Poisson Equations Based on Radial Basis Function Neural Networks
Authors: Lu Peixiao , Sun Shaoming
Published: January 2024

As a widely used equation in electrostatics, the Poisson equation has significant research value in numerical solution. The basic principle of existing methods is to divide the solution domain into various grids and solve the numerical solutions at each grid node. Therefore, the accuracy of the solution is strongly correlated with the grid density divided. Based on this, this paper proposes a grid-free numerical calculation method that requires far fewer model parameters than traditional methods, and can ignore the order of the equation to solve high-dimensional Poisson equations. Given a Poisson equation, which has a certain type of boundary condition. A certain number of coordinate points are selected on the solution space and its boundary to construct a dataset. Using automatic differentiation technique to fit the differential operator in the equation, a loss function is constructed by incorporating the given boundary conditions or initial conditions, and the final numerical solution is obtained through iterative optimization algorithms. In the numerical experiment section, the algorithm proposed in this paper was used to solve the two-dimensional and three-dimensional Poisson equations with given exact solutions. The relative errors between the numerical solution and the true solution were [Formula: see text] and [Formula: see text], which are within the acceptable range. This proves that the proposed algorithm is feasible for solving the two-dimensional and three-dimensional Poisson equations with precise solutions. Secondly, the proposed algorithm is used to solve the four-dimensional Poisson equation with first-type boundary conditions, and the relative error range of the solution was within [0,0.56], which successfully extends the algorithm to solve high-dimensional Poisson equations and verifies its feasibility and efficiency in solving high-dimensional Poisson equations regardless of the dimension restriction.
Real-Time Early Warning Method of Distribution Transformer Load Considering Meteorological Factor Data
Authors: Li Shan , Huang Wei , Zhou Yangjun , Lu Xin , Yao Zhiyang
Published: January 2024

The traditional real-time load warning method for distribution transformers has problems such as low recall rate, low warning accuracy, and long warning time, which may lead to potential equipment failures or overload situations not being detected and dealt with in a timely manner, increasing the safety risk of transformer operation and potentially causing safety issues such as equipment damage, fire, or power outage. Therefore, a real-time early warning method of distribution transformer load considering meteorological factor data is designed. The meteorological factor data are collected by the light sensor, humidity sensor, temperature sensor and rainfall sensor, and the load data collection architecture is built by the load monitor, central master station and maintenance station to realize the load data collection of the distribution transformer. The K-nearest neighbor (KNN) method is used to process the missing values of the data, and the LOF algorithm is used to determine the local outliers and eliminate the outliers in the data set to achieve data cleaning. Considering the load loss, hot spot temperature and meteorological factors of the distribution transformer, an early warning model is built, and the cleaned data are input into the model to realize Real-time early warning of the distribution transformer load. The experimental results show that the recall rate of this method varies from 95% to 97%, the accuracy rate of early warning is always above 94%, and the maximum value of early warning time is 0.63s. Having good early warning ability.
Exploring the Role of E-Entrepreneurship in Fostering Future Green Economy and Environmental Policies: A Study on Saudi Women Entrepreneurs
Authors: Alzamel Samar
Published: January 2024

This study examines the role of e-entrepreneurship in fostering the future economy, with a specific focus on Saudi women entrepreneurs. The emergence of digital technologies and the internet has opened up new opportunities for entrepreneurship, especially for women facing traditional barriers to business participation. In particular, the Kingdom of Saudi Arabia (KSA) has witnessed many women entrepreneurs who leverage e-commerce platforms to establish and grow their businesses. Combining e-entrepreneurship with environmental conscience depicts a future in which sustainable development and economic prosperity coexist. This research will explore the motivations, challenges, and strategies employed by Saudi women entrepreneurs in the e-commerce sector and analyse the impact of their entrepreneurial activities on the future economy. The study followed a quantitative and post-positivist approach. Data were collected cross-sectionally from the women working in different start-ups in the big cities of KSA. The study adopted the systematic random sampling approach to reach the respondents. A total of 500 questionnaires were distributed. However, 388 were included for analysis after the screening process. The findings reveal that e-entrepreneurial significantly impacts women’s entrepreneurial and economic growth. Moreover, Entrepreneurial self-efficiency significantly mediates the relationship between women’s entrepreneurial and economic growth. The findings comprehensively understand complex dynamics and guide future research and practical applications in related domains. Furthermore, the study found that Saudi women entrepreneurs should receive financial and technical support to initiate their ventures. Moreover, policy recommendations of the study demand addressing cultural barriers and fostering an enabling environment for their entrepreneurial endeavours.
Assessing Routing Algorithms for Payment Channel Networks
Authors: Lobmaier David , Konlechner Rafael , Schulte Stefan , Weber Ingo
Published: January 2024

Payment Channel Networks (PCNs) are a promising approach to overcome scalability issues of blockchains. To achieve efficient payments in PCNs, it is necessary to route transactions between a payer and a payee. Especially in large-scale PCNs, multi-hop routing becomes necessary, since transactions need to be relayed by nodes. For this, a scalable routing algorithm is needed, which fits the individual objectives of PCN users.

In this article, we study whether routing protocols from the field of Wireless Sensor Networks can be applied in PCNs. To this end, we first derive requirements for routing in PCNs, select suitable approaches, and analyze to which degrees they perform well and meet the requirements. We adapt selected protocols and evaluate them with regard to the lengths of payment paths, fees, and success ratio.
Supplementary Document 2 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing
Authors: Wang Chien-Wei , Weaver Simon D. , Boonpattrawong Nicha , Schuster-Little Naviya , Patankar Manish , Whelan Rebecca J.
Published: January 2024

DNA alignment
Supplementary Document 1 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing
Authors: Wang Chien-Wei , Weaver Simon D. , Boonpattrawong Nicha , Schuster-Little Naviya , Patankar Manish , Whelan Rebecca J.
Published: January 2024

R script used for proteomics data analysis
Figure S8 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing
Authors: Wang Chien-Wei , Weaver Simon D. , Boonpattrawong Nicha , Schuster-Little Naviya , Patankar Manish , Whelan Rebecca J.
Published: January 2024

Comparison of AlphaFold and I-TASSER predicted MUC16 tandem repeat model. The repeat 6 structure predicted by AlphaFold (brown) and I-TASSER (blue) are overlayed. The SEA domains predicted by the two algorithms show high similarity.
Figure S7 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing
Authors: Wang Chien-Wei , Weaver Simon D. , Boonpattrawong Nicha , Schuster-Little Naviya , Patankar Manish , Whelan Rebecca J.
Published: January 2024

AlphaFold predicted models of individual tandem repeats. (A)-(S) Repeats 1-19.
Figure S1 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing
Authors: Wang Chien-Wei , Weaver Simon D. , Boonpattrawong Nicha , Schuster-Little Naviya , Patankar Manish , Whelan Rebecca J.
Published: January 2024

Set of three primer sequences originally developed for RT-PCR. The three primer sets were found to be redundant, which suggested that the tandem repeat region is shorter than that reported in AF414442.2.
FIGURE 5 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing
Authors: Wang Chien-Wei , Weaver Simon D. , Boonpattrawong Nicha , Schuster-Little Naviya , Patankar Manish , Whelan Rebecca J.
Published: January 2024

MUC16 model proposed in this study. The model includes: a highly glycosylated N-terminal domain, a 19-unit tandem repeat domain that contains the CA125 epitopes, and a short C-terminal domain that includes a membrane-spanning region. The inset shows a representative 3D structure of one tandem repeat domain, predicted by AlphaFold. The C-loop (residues 59–79) is shown in red, with the cysteine residues shown in salmon. The unstructured proline/serine/threonine-rich region is omitted for clarity. White slashes within the N-terminal domain and tandem repeat domain show locations where amino acids are not explicitly shown for clarity. Figure created with https://Biorender.com.
Life Orientation and Academic Performance of Selected Students with Physical Disabilities
Authors: Diego Arnel A. , Villegas Roland D. , Olegario Ma Lourdes P. , Resuello Jobelle T.
Published: January 2024

Disabled individuals often spend their lives grappling with low levels of optimism and unmet needs. It has been widely accepted that people with disabilities generally have fewer educational opportunities and a lower quality of life than their non-disabled counterparts. This present study employs descriptive research to investigate the relationship between life orientation and academic performance among selected students with physical disabilities. The participants were chosen through purposive sampling, consisting of sixty-four respondents from selected schools in Manila. Data were collected using a survey instrument, The Life Orientation Test Revised (LOTR). The researcher utilized the Z-test, H- test, weighted mean, and ANOVA to identify differences in variables, and Pearson's r to explore relationships. The findings revealed that students with physical disabilities are optimistic individuals; they accept and confront their condition despite the inconveniences and pain it may cause. Moreover, the present study showed that the higher the level of life orientation, the better the academic performance. Therefore, there is a need for the educational system to consider the life orientation of students when developing new strategies and approaches to understanding and teaching students with physical disabilities.
Exploring Employability, Program Relevance and Job Satisfaction among BS Criminology Graduates
Authors: Nayoyos-Refugia Jennifer M.
Published: January 2024

Workplace fulfillment is critical for motivating workers, boosting productivity, and improving general wellbeing. It also emphasizes relevance of the program to match the industrial demands, as this drives the creation of educational policies, practices, funding allocation, and curriculum design to effectively meet the demands of the general public, employers, and students. This descriptive study investigated the employment status, program relevance, and job satisfaction of LSPU-SPCC BS Criminology graduates from batches 2015 to 2019. The study utilized a descriptive design with a mixed-methods approach having 205 graduates that responded the self-made questionnaire. Result shows that majority of graduates were found to be male and of single civil status, and they were mostly employed by governmental agencies with permanent status, particularly the Philippine National Police. The ratings for skills, curriculum, OJT programs, faculty competency and expertise, instruction and work-related values were favourable to their career but there are prospects for development. Graduates feel quite satisfied with their jobs, particularly with regard to the pay, perks, and job security, although there is space for improvement in terms of promotion chances. Job satisfaction was found to be influenced by healthy working relationships. Employers can take advantage of these findings to foster a positive work environment and provide opportunities for career growth, leading to increased job satisfaction and overall organizational success. The findings suggest that continuous program improvement, guided by program administrators and educators, is necessary to better prepare graduates for careers in criminology.
Development and Validation of a Scale to Measure Academic Resilience of Students
Authors: Honra Joelash R.
Published: January 2024

Academic resilience can lead to better behavior and results for disadvantaged learners since they can achieve good educational outcomes despite diversity. Several studies mentioned that various protective factors could affect resilience among students. On the other hand, several risk factors also directly affect its development among learners. This research focuses on the critical role of academic resilience in fostering positive behavior and outcomes among disadvantaged learners, enabling them to achieve educational success despite diverse challenges. Drawing on existing literature and personal interviews with secondary school students in Bulacan, a scale was developed to assess academic resilience, incorporating both risk and protective factors identified by Kutlu and Yavuz (2016). The four-point Likert scale, administered to 591 students, demonstrated promising psychometric features upon validation. Exploratory factor analysis revealed two distinct internal and external protective factors comprising 37 items in the newly developed FLARS instrument. Rigorous criteria for factorability were met, including a Kaiser-Meyer-Olkin measure of sampling adequacy exceeding the recommended threshold at .915 and a statistically significant Bartlett's test of sphericity (X2(666) = 7351.246, p < .05). Furthermore, the overall Cronbach's alpha coefficient of .901 indicated exceptional reliability. Consequently, the FLARS instrument emerges as a reliable and valid tool for measuring academic resilience levels among secondary school students. While the study recommends readministering the instrument to a larger sample for enhanced reliability, validity, and generalizability, it marks a significant contribution to the understanding and assessment of academic resilience in educational contexts.
Exploring The Faculty and Students’ Readiness Level for The Effective Implementation of Physical Activity Toward Health and Fitness Courses (PATHFIT)
Authors: Pineda Herman S. , Andal Edilberto Z. , Hermosa Jherwin P.
Published: January 2024

he study aimed to evaluate students' preparation for physical activity in health and fitness courses at Laguna State Polytechnic University (LSPU) campuses. A descriptive correlational methodology was used in the study, which included 920 students and 48 faculty members. The findings demonstrate that PATHFIT courses are generally and substantially prepared at all LSPU campuses. The range of mean scores for each indicator demonstrates a high level of readiness, and given the modest standard deviation, readiness levels across several campuses may be constant. The courses specifically show how to prepare for streamlining curricular materials, objectives, methods, staffing policies, workforce management, alternative programs, physical education curriculum, laboratories, and equipment. These places a strong basis and foundation for the implementation of PATHFIT courses and are much ready.

ANOVA results for the PATHFIT course implementation level throughout LSPU campuses, regarding the availability of facilities and resources, faculty qualification, and support system, revealed PATHFIT course implementation levels varied significantly among LSPU campuses. However, no appreciable differences across LSPU campuses' implementation levels of PATHFIT courses regarding the availability of facilities and resources and evaluation and monitoring attributable to the between-groups variation.

In summary, regression analysis shows there are no appreciable differences between campuses regarding achieving goals and objectives, assessment and monitoring, or overall implementation level, and there are appreciable variations in the availability of facilities and resources, faculty credentials, and support systems. These results show how PATHFIT courses must be implemented consistently and successfully throughout LSPU to solve the inequalities in resources and qualifications between campuses.

The study recommends ongoing promotion and improvement of health and fitness programs at LSPU campuses, as well as targeted interventions to enhance preparation levels and foster a culture of physical activity. Future research can explore innovative strategies to support a physically active lifestyle and contribute to overall well-being within the university community.
Indigenous Tourism in Nueva Ecija: Challenges and Opportunities
Authors: Fernandez Khriz N.
Published: January 2024

Indigenous tourism played an essential role to help build local and national economy. It served as the spine of every municipality which hold attracting tourism sites. Hence, indigenous tourism as emerging tourism attraction also held a frontier of economic power that help boost local economy. It was concluded that ICCs/IPs encountered certain challenges as to cultural sensitivity, economic stability and environmental preservation which hampered the continued development of indigenous tourism. Meanwhile, the results also showed that in spite of these challenges, opportunities were also seen in which, indigenous tourism provided wider avenues for the development of ICCs/IPs way of living through creation of more employment and business opportunities which helped them generate more income to meet their needs. Conclusively, indigenous tourism in the province empowered ICCs/IPs cultural, environmental and economic opportunities.
The Saucer Bugs (Hemiptera: Heteroptera: Naucoridae) of French Guiana
Authors: Sites Robert W. , Clavier Simon , Shepard William D.
Published: January 2024

Northeastern South America has been historically undersampled across most biota.  Surveys conducted for aquatic insects in French Guiana during the past 14 years have resulted in the collection of 16 species of Naucoridae, of which 10 are new country records.  Of these 16 species, 10 are in the subfamily Ambrysinae, one in Ilyocorinae, and five in Limnocorinae.  At least six of these species are considered rare, as very few specimens are known.  A checklist, annotated list, distribution maps, and an illustrated key to identify adults of these species are presented.
The Chinese Educational Idioms That the Chinese Shall Live By
Authors: Liu Wei , Zhang Xiaojun
Published: January 2024

With the conviction that formulaic expressions in a language are carriers of stable thought patterns of its culture, the paper conducts a thematic analysis of Chinese educational idioms with the goal of exploring the traditional Chinese educational values reflected in the Chinese language use. Altogether, about 100 Chinese idioms that pertain to teaching, learning and parenting are identified from a Chinese Chengyu (idioms) dictionary. Findings of this study challenge the common practice of borrowing Western pedagogical discourses to justify curriculum change initiatives in China, arguing that the traditional Chinese educational discourses should be retained in order to secure a strong cultural identity for young generations.
Of the Meaning of Pedagogy: W. E. B. Du Bois, Racial Progress, and Positive Propaganda
Authors: Blume Oeur Freeden
Published: January 2024

A silence in the resurgence of scholarship on W. E. B. Du Bois has been his work as an instructor. This article uses Du Bois’s early teaching experiences and reflections on the “ugly” progress of schooling to ask: What should guide the pedagogy of sociology instructors when racial progress is so ugly? I sketch here a pedagogy inspired by Du Bois—who was the teacher denied—which is motivated by a positive notion of propaganda. Du Bois was a radical pedagogue whose mixed-methods instructional agenda informed a critical Black Sociology and bridges recent calls by American Sociological Association leadership for a discipline that is more emancipatory and educative. Embracing the right to propaganda gives pedagogical teeth to honest appraisals on racial progress. Triangulating art, science, and agitation in our pedagogy offers a general compass, and my article concludes with one direction that compass might lead: a classroom assignment where my undergraduate students became “print propagandists.”
Need Support and Need Thwarting: A Meta-Analysis of Autonomy, Competence, and Relatedness Supportive and Thwarting Behaviors in Student Populations
Authors: Howard Joshua L. , Slemp Gavin R. , Wang Xiao
Published: January 2024

In this meta-analysis, we review the nomological networks of six need-supportive and need-thwarting categories, as defined by self-determination theory (SDT), and as they apply to students in educational contexts. We conducted a synthesis of 8693 correlations from 637 samples ( N = 388,912). A total of 72 covariates were examined, resulting in 183 meta-analytic effects reported. Results indicate that teachers and parents who experience psychological need satisfaction and well-being are seen as more supportive. Supportive teacher behaviors correlated positively with a range of desired student outcomes, including performance, engagement, and well-being. Thwarting behaviors tended to display the opposite pattern. Our results are consistent with the theoretical expectations of SDT, yet questions remain concerning the incremental validity of these constructs. We highlight the need for further research on (a) factors that cause teachers to provide support and (b) the specific behaviors within each category to distinguish these categories and increase practical utility.
Bidirectional longitudinal relationships between parents’ positive co-parenting, marital satisfaction, and parental involvement
Authors: Zhang Ye , Xie Ruibo , Yan Ru , Wang Die , Ding Wan , Sun Binghai
Published: January 2024

Numerous studies have shown that co-parenting plays an important role in marital and parent-child interactions. However, little is known about the bidirectional associations between positive co-parenting and marital and parent-child factors, as well as the dynamic underlying mechanisms. This study used cross-lagged panel model (CLPM) to explore the bidirectional longitudinal relationship between positive co-parenting, marital satisfaction, and parental involvement among Chinese parents from a positive family multiple systems perspective. A sample of 668 father-mother dyads (father’s Mage = 36.47, SDage = 5.34; mother’s Mage = 35.45, SDage = 5.07) completed a series of questionnaires at three time points (approximately spaced 1 year between each time point). The results showed that positive co-parenting positively predicted marital satisfaction and parental involvement and that marital satisfaction positively influenced parents’ positive co-parenting, whereas the effect of parental involvement on positive co-parenting was significant among fathers. Additionally, fathers’ marital satisfaction can affect their involvement, but this effect is negligible among mothers. Finally, parental marital satisfaction mediated the relationship between positive co-parenting and the next stage of positive co-parenting. This study provided new ideas and interventions to strengthen family cohesion and harmony.
Covid-19 Pandemic’s Enduring Impact on Urban Mobility: The Case of Free-Floating Bike Sharing in Padova, Italy
Authors: Cavattoni Margherita , Comin Matteo , Silvestri Francesco
Published: January 2024

The spread of the Covid-19 virus all around the globe drastically changed our lifestyles and our habits. Among all aspects affected by the pandemic, mobility certainly underwent huge changes. Recognizing these shifts in transportation behaviors enables urban planners to tailor infrastructure and policies, ensuring effective transit in the aftermath of the pandemic. This work consists in a data-intensive study of the Padova bike sharing system in Italy, which we utilized as case study, to understand the enduring effects of the pandemic. To this end, we retrieved, pre-processed and analyzed the data relative to three periods that are representative of pre-pandemic, pandemic, and post-pandemic worlds. We combined the bike-sharing data with geographical, meteorological, and user information. We then performed both a temporal and a spatial-temporal analysis, by generating a graph from the rides network. By analysing the rides graph properties and connectivity, we observed an increase in the total amount of rides, as well as an expansion of the service toward more peripheral areas, and a greater predisposition to use the bike-sharing system.