bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphological aspects and pathological impacts of cystic echinococcosis in liver of slaughtered sheep and host-parasite relationship
Authors: Al-Ghamdi A. , Ibrahim M. , Idris E. , Al-Doaiss A. , Morsy K.
Published: September 2023

ABSTRACT Cystic echinococcosis (CE) is a parasite-borne disease caused by the larval stage of Echinococcus granulosus belonging to family Taeniidae, is an endemic disease, distributed worldwide as a neglected parasite with socioeconomic repercussions. It causes severe alterations in liver of infected host, and it could be fatal if untreated. The main objective of the present study is to measure and evaluate the condition of hydatidosis in slaughtered sheep in Al Baha region, Saudi Arabia. A total of 601 slaughtered sheep in Al Baha abattoirs were examined for hydatidosis during the year 2020. Various organs were examined for the presence of parasite cysts, and the cyst contents were examined by light microscopy. Also, liver sections infected with cysts were examined for pathological alterations and host-parasite interactions. Forty-two animals were infected (6.09%) with the highest prevalence during summer. During gross examination, it was observed that the sheep liver is the most affected organ by the disease. The liver contained multiple cysts with varying sizes, filled with clear to slightly turbid fluid containing protoscoleces. Detailed sections of the infected liver revealed significant fibrosis around the central vein, portal vein congestion, infiltration of inflammatory cells, and necrosis. Sections through hydatid cysts showed the presence of three surrounding layers with a laminar membrane bordering the cyst lined by a germinal epithelium surrounding several brood capsules with many protoscolesces inside supported by a set of rostellar hooklets. Considerable efforts should be spent to control the transmission of parasitic cysts and inhibit the incorrect disposal of infected meat from slaughterhouses. Also, more focus should be done on epidemiological and control programs of these parasites.
Reduction of temporomandibular joint (TMJ) luxation in a horse - case report
Authors: Souza A.P.A. , Torres R.V.S. , Oliveira C.J. , Silva F.W.S. , Franco F.A. , Florence C.O. , G. Filho U.C. , Orozco C.A. Graça , Cabral J.P.M.S.
Published: September 2023

ABSTRACT Luxation of the temporomandibular joint (TMJ) in horses, despite being an uncommon condition, is often associated with local trauma involving the head. Its clinical importance is mainly related to the painful injury and impairment of the multiple movements involved in chewing and breaking foods. The objective of the current work is to describe the manual reduction technique of TMJ dislocation in a 6-year-old Mangalarga Marchador stallion with a history of inability to close the oral cavity and lateral displacement of the mandible. In the radiographic and ultrasonographic evaluation of the region a rostral displacement of the mandibular condyle was observed. Manual reduction was effective with the patient under dissociative anesthesia, progressing to medical discharge within 12 days.
Study on spatio-temporal prevalence and hematological attributes of bovine Babesiosis in cattle population of Layyah, Southern Punjab, Pakistan
Authors: Ahmad A. , Ali Z. , Lashari M.H.
Published: September 2023

ABSTRACT The present study was conducted to investigate the spatiotemporal prevalence of bovine babesiosis in cattle population (n=376) of Layyah, Pakistan as affected by location, age, breed, gender, and seasons. Blood samples were collected aseptically and assessed for babesiosis through microscopy and PCR, and through automated analyzer for hematological attributes. Overall results of prevalence through PCR in cattle population showed significantly (P≤0.05) lower prevalence of 19.4% (n=72/376) as compared to 37.2% (n=140/276) through microscopy. None of the studied cattle from Cholistani breed were Babesia-positive. However, significantly (P≤0.05) higher prevalence was noticed for crossbred cattle (46.7%, n= 50/107) followed by that in Friesian (16.1%, n= 10/62), Jersey (7%, n= 5/71) and Sahiwal (6.9%, n= 7/101) cattle breeds. Female cattle (19.5%, n= 55/281) and age group 1 (Up to 2 years) (40%, n= 42/105) had higher prevalence of Babesia as ascertained through PCR in comparison to their counterpart groups. Significantly (P≤0.05) higher prevalence of 35.9% (n=60/167) was shown in summer as compared to that in winter season (5.7%, n= 12/209). All the positive samples produced the 490bp amplicons specific and typical for Babesia bigemina. Hemoglobin concentration, erythrocytic count, hematocrit and mean corpuscular volume were significantly (P≤0.05) lower in babesia-positive cattle as compared to healthy ones.
Hematological effects in acute toxicity generated by the administration of honeybee (Apis mellifera L.) venom in European rabbit (Oryctolagus cuniculus)
Authors: Pavel G. , Bratu D. , Bejenariu D. , Grădinaru A.C.
Published: September 2023

ABSTRACT Various studies demonstrated risks and benefits in the use of bee venom, a natural product characterized by a complex organic structure. In this study, we aimed to test the effects of bee venom administration in rabbits. Hematological investigations were carried out by determining specific blood indicators at different time intervals and at varying doses of venom. The obtained results showed a toxic action dependent on the dose and the daily cumulative effect; in the case of erythrocyte and platelet parameters, bee venom progressively generated the onset of thrombocytosis and reduced hemolysis for the short term. In the case of leukocytes, the administration of bee venom caused an increase of WBC count, segmented neutrophils and Ne/Lymph ratio, proportional to the dose and time of bee venom inoculation, but within the reference range; the average values of unsegmented neutrophils and basophils was above the upper limit of the normal range, with oscillating changes during the experiment; monocytosis and eosinophilia was also noted at different doses and times of venom inoculation. The investigations carried out 7 days after stopping the administration of bee venom revealed, in many cases, a progressive return to normal for the hematological parameters, except blood platelets.
Assessing transformation methods for group comparisons under violated assumptions: type I error rate and test power
Authors: Ergin M. , Koşkan Ö.
Published: September 2023

ABSTRACT In this study, some transformation methods that are applied when the assumptions of analysis of variance are not met are evaluated in terms of type I error rate and the test power, under circumstances with different distributions, number of groups, number of observations, variance ratios, and different standard deviation differences. The data set used in the study consisted of random numbers generated from N (0,1), and χ2(3) distributions using the random function of the Numpy library in the Python programming language. The logarithmic, square root and root transformations were evaluated on ANOVA based on simulation combinations. It was observed that the transformation techniques of taking the square root after adding 0.5 and 0.375 to the data were relatively more reliable compared to other transformations in terms of type I error rate. However, in every case, type I error rate determined at the beginning of the experiment increased both before and after the transformation was applied. In particular, interestingly, the third and fourth degree root transformations gave better results of test power in the right skewed distribution. In addition, we compared the transformation techniques in question to determine the normality of the data and the homogeneity of variances by a real data.
Can bovine embryos be successfully transferred after 40 years of cryopreservation?
Authors: Camacho-Ronquillo J. , Posadas-Manzano E. , Utrera-Quintana F. , Hernández-Hernández J. , Gallegos-Sánchez J. , Cruz-Aviña J. , Villa-Mancera A.
Published: September 2023

ABSTRACT Global advances in reproductive biotechnology have allowed for the transfer of embryos from donor females with high genetic merit to recipients using the cryopreservation technique, which preserves an embryo of excellent quality and viability, thereby achieving a feasible pregnancy rate. The objective of this study was to evaluate the quality and viability of Holstein embryos that have been cryopreserved for more than 40 years under glycerol freezing. The embryos were transferred to the recipient heifers using a non-surgical method. Two 17-month-old Holstein heifers (360 kg live weights) which were clinically healthy and reproductively active were used as the recipients. Two bovine embryos of Grade 1 quality were thawed and evaluated for their morphology. Of the two embryo transfers, one pregnancy was achieved, resulting in the birth of a calf. Therefore, embryos frozen in liquid nitrogen and glycerol as a cryopreservative for more than 40 years maintained their quality and viability to produce a live calf.
Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats
Authors: Fathalla A.S. , Ibrahim M.A. , Mohamed S.R. , Dkhil M.A. , Thagfan F.A. , Abdel-Gaber R. , Soliman D.
Published: September 2023

ABSTRACT The present work aims to evaluate anticancer performance of Cassia alata methanolic leaf extracts (CMLE) in ethyl carbamate-stimulated lung adenocarcinoma (LAD) in differentiation to the function of Cisplatin (CIPL). Rats were divided into four groups: (1) control (CONT), (2) lung-adenocarcinoma (LAD) injected intra-peritoneally with 1g/kg ethyl carbamate once weekly for a month, (3) LAD+CMLE administered 500 mg/kg CMLE orally for the last two months of the experiment, and (4) LAD+CIPL treated group, injected 2.5 mg/kg Cisplatin intraperitoneally once weekly for the last two months of the experiment. Light and electron microscopic examinations revealed adenocarcinoma development in terminal bronchiole besides some histopathological changes in the LAD group such as atypical, exaggerated collagen fibers, increment of mucinous content, and increasing of PCNA positive immunoreactivity whereas electron microscopy investigation exposed that papillary adenocarcinoma originated from Clara cells in the LAD group. The LAD+CMLE treated group showed no tumor masses and nearly all with normal lung histology. It also recovered the normal ultrastructure of bronchiolar Clara cells. CMLE treatment offers a new alternative cure with less toxicity than Cisplatin for lung cancer therapy. Hence, CMLE would be employed as a novel supply of anti-cancer compounds combating lung cancer.
Word final prolongations: acoustic characteristics and influence on speech fluency perception
Authors: Souza Lívia Maria Santos de , Martins-Reis Vanessa de Oliveira , Santos Pâmela Jesus dos , Gomes Dianete Ângela do Valle , Lima Aveliny Mantovan , Celeste Letícia Correa
Published: September 2023

ABSTRACT The aim of this study was to characterize word final prolongations in individuals with and without stuttering as well as to investigate the influence of end of words prolongations on speech fluency perception. In Experiment 1, 14 subjects were submitted to speech fluency evaluation for analysis of duration and average frequency of extended phones at the end of words. In Experiment 2, twenty lay judges were asked to judge the fluency degree of utterances without disfluency, utterances containing prolongations and utterances containing filled pauses. In experiment 1 the groups differed only in the duration’s variation; in both groups the prolongations in monosyllabic words prevailed; 80% of the prolonged phones in both groups were vowels. In experiment 2 no significant difference was found in the comparison between the judgements of prolongations and filled pauses. The utterances without disfluency differentiated themselves significantly from the others. We suggest that characteristics such as position in the word, duration and physical concomitants should be considered before deeming prolongations as a stuttering-like disfluency.
Pesquisa narrativa e audiodescrição: outra opção metodológica
Authors: Silva Manoela Cristina Correia Carvalho da , Barros Alessandra Santana Soares
Published: September 2023

RESUMO A Pesquisa Narrativa é uma metodologia que consiste na coleta de histórias sobre um determinado assunto em busca de informações para entender um fenômeno específico. Em geral, ela é utilizada como um recurso para dar voz aos sujeitos do estudo. Neste artigo, apresentamos um exemplo de como a Pesquisa Narrativa pode ser utilizada como uma alternativa aos tradicionais estudos de recepção na área da audiodescrição (AD). Para tanto, nos debruçamos sobre o percurso metodológico da tese de doutoramento intitulada Para além do visível: princípios para uma audiodescrição menos visocêntrica, na qual foram analisadas duas autobiografias de autoria de pessoas com cegueira adquirida: Touching the Rock, de John Hull, e Out of Darkness: A Memoir, de Zoltan Torey. As obras foram estudadas a partir da metodologia da Pesquisa Narrativa e os dados foram trabalhados através da análise temática nos moldes propostos por Braun e Clarke. A análise empreendida enfatizou a importância, entre outros, do respeito aos diferentes perfis do público-alvo, de uma exposição de qualidade, precoce e continuada, e da associação da AD a experiências multissensoriais.
Dar uma pedalada fiscal ou marcar um gol de placa? Futebol e política no campo da fraseologia
Authors: Salvador Carlene Ferreira Nunes , Souza Davi Pereira de
Published: September 2023

RESUMO Este artigo, à luz da teoria fraseológica de Mejri (1997; 2012), objetiva descrever e analisar fraseologismos no discurso político que remetem originalmente ao domínio do futebol, e vice-versa, mantendo ou ressignificando o sentido fraseológico em função do contexto de uso. Para tanto, utilizamos como corpora as pesquisas de Salvador (2017) e Souza (2018). Primeiramente, consultamos os dois repertórios lexicais, procurando identificar sequências que estivessem relacionadas a ambos os domínios em pauta. Posteriormente, isolamos 30 unidades e seus respectivos contextos, procedendo-se à análise sintática e semântica. Os resultados indicam que os dois domínios estão relacionados e se influem linguisticamente, sobretudo o discurso político que, apropriando-se de sequências forjadas no domínio do futebol, mobiliza estratégias que buscam a persuasão do interlocutor, baseando-se na construção de uma identidade entre leitores (eleitores) e torcedores, considerando que o futebol representa, principalmente no Brasil, um elemento cultural significativo capaz de promover uma sensação patriótica de nacionalismo. Fraseologismos como baixar a bola, bola da vez, pisar na bola, campo político e pátria de chuteiras ilustram como futebol e política se cruzam no campo da fraseologia.
Many hands on this study: Development of a metonymy comprehension task
Authors: Siqueira Maity , Melo Tamara , Duarte Jr Sergio , Baiocco Laura , Ferrari Caroline Girardi , Lopes Nichele
Published: September 2023

ABSTRACT Metonymy is a pervasive linguistic/cognitive mechanism in everyday language. Still, studies assessing its comprehension are rare in the literature. Our goal is to present the elaboration of a verbal metonymy comprehension task in Brazilian Portuguese as well as test it using pilot studies. The task was based on the cognitive linguistics framework and psychometric guidelines were considered. The construction of the task considered psycholinguistic variables and included a conventionality task and an expert analysis. Three studies (N = 290, ages ranging 2 to 54 years old) were conducted until we reached a final version. The study resulted in a task composed of one practice item and six test items. Each item includes a sentence-stimulus and two questions (one open-ended and one closed-ended). Together, the items make up a raw score that represents metonymy comprehension. Data obtained from the pilot studies show that metonymy comprehension improves gradually with age and that there is a significant difference between items in both types of questions. This is in consonance with the literature, and thus points towards the instrument’s construct validity. The study results in a task that presents enough sensitivity to gauge comprehension of this phenomenon at different ages.
De la guerra al festival: análisis de las metáforas empleadas en la cobertura de la Copa Mundial de Fútbol 2018 por Marca y Sovetsky Sport
Authors: Mukhortikova Tatiana
Published: September 2023

RESUMEN Este estudio analiza las metáforas extraídas de los textos informativos, las crónicas y los reportajes dedicadas a la Copa Mundial de Fútbol 2018, publicadas en dos periódicos deportivos y editados en dos países distintos en dos idiomas diferentes: español y ruso, desde el 14 de junio hasta el 15 de julio 2018. Partimos de la propuesta metodológica del análisis de la metáfora periodística fundamentada en los postulados pragmáticos (Grice 1996; Teruel 1995; 1997) y cognitivos (Lakoff & Johnson 1980), detallados en el marco teórico. Suponemos la presencia de dos tipos de metáforas: metáforas culturales, propias de una cultura y un idioma, y metáforas universales presentes en ambos casos. Este estudio tiene un enfoque comparativo en perspectiva sincrónica y permite contrastar las asociaciones en dos idiomas procedentes de distintas familias lingüísticas para establecer similitudes y diferencias.
Quando o outro narra pelo afásico: observando as categorias interacionais de avaliação e de entextualização
Authors: Oliveira Lívia Miranda de , Bastos Liliana Cabral
Published: September 2023

RESUMO Considerando a diversidade de configurações das narrativas orais enquanto histórias do passado, do presente ou do futuro, breves ou longas, de experiência pessoal ou vicárias, assumimos que, no processo de narrar, ações como avaliações e entextualizações são coproduções dos interactantes, e partimos para a investigação dessas duas categorias em narrativas orais sobre acometimentos neurológicos contadas por acompanhantes de afásicos. Em nossas análises, valemo-nos dos instrumentais teórico-metodológico da Análise de Narrativa (um afluente da Análise do Discurso) bem como de instrumentais teóricos advindos de estudos sociológicos e antropológicos que contribuem sobremaneira para a essa vertente da Análise do Discurso. Como fruto das nossas investigações, observamos que construções de sentidos foram alcançadas interacionalmente via avaliações e entextualizações; recursos estes que também atuaram na configuração das narrativas como um drama e como um relato reportável. Podemos, então, advogar que a historiabilidade das narrativas foi construída interacionalmente com o uso de recursos performáticos pelos familiares dos afásicos.
Sujeito pronominal expresso e nulo em orações negativas do português brasileiro
Authors: Othero Gabriel de Ávila , Silva Susana Miranda da
Published: September 2023

RESUMO Investigamos o fenômeno da omissão e expressão de sujeitos pronominais em orações negativas simples (e.g. Ele não come carne), um conhecido contexto de resistência para o sujeito nulo em PB. Realizamos pesquisa em um corpus de língua falada recente e buscamos responder três questões centrais: (i) há maior ocorrência de sujeitos pronominais expressos ou nulos em orações negativas?; (ii) qual é a relação entre sujeitos pronominais expressos e nulos e os traços semânticos de seus antecedentes?; e (iii) as orações negativas simples se comportam como as orações com dupla negação no que toca às ocorrências de sujeitos nulos e pronominais expressos? Os resultados mostram que há maior ocorrência de sujeitos nulos do que expressos na amostra analisada, corroborando a ideia de que as sentenças negativas atuam como um contexto de resistência do sujeito nulo. Também verificamos uma relação entre os traços [+humano] e [+gênero semântico] e os sujeitos pronominais expressos, e uma relação entre o traço [-gênero semântico] e o sujeito nulo. Finalmente, verificamos que há maior frequência de sujeitos nulos em duplas negações (seguindo a literatura) do que em negações simples, o que fortalece a hipótese de que as orações com dupla negação veiculam conteúdos mais ativados discursivamente do que as negações simples.
A sessão de psicanálise como gênero do discurso: enquadre, terapia e encontro de vozes em visada bakhtiniana
Authors: Moll Eduardo da Silva , Fanti Maria da Glória Corrêa di , Rosa Kelli Machado da
Published: September 2023

RESUMO Embora pouco debatido na área dos estudos bakhtinianos, um marco da produção teórica do Círculo de Bakhtin foi a crítica de Volóchinov ao freudismo. Refletindo criticamente sobre o posicionamento do autor acerca da psicanálise, este artigo objetiva investigar o pequeno acontecimento social psicanalítico como um gênero do discurso em sua especificidade terapêutica, considerando o entrecruzamento de vozes constitutivo desse evento. Com uma pesquisa bibliográfica, recuperamos os pressupostos de Bakhtin e o Círculo que embasam o construto de gênero do discurso e investigamos o papel do enquadre na terapia psicanalítica freudiana. Conceitos como o de arquitetônica e de heterodiscurso para o Círculo, assim como o de resistência e de transferência para Freud ajudaram a explorar o lugar do setting na terapia. Defendemos que a relação discursiva psicanalítica especifica-se pela possibilidade de fazer da interação discursiva um espaço-tempo aberto ao diálogo inconclusível próprio do encontro terapêutico e da palavra em elaboração.
Los Hablantes: Apuntes Críticos en torno a la Creación y Uso de una Categoría Lingüística en la Tradición Discursiva de los Estudios Fonético-Fonológicos del Mapudungun en Chile
Authors: Alvarado Marco Espinoza , Vinet Aldo Guillermo Olate , Liempi Rosa Gabriela Catalán
Published: September 2023

RESUMEN Se examina críticamente la construcción y uso de la categoría “hablante” en los estudios fonético-fonológicos de la lengua mapuche en Chile, los cuales constituirían una tradición discursiva académica local. Se consultó un conjunto de 20 artículos producidos en esta tradición en los últimos 10 años. Fue posible observar la ausencia sistemática de perfiles sociolingüísticos de las comunidades estudiadas y de una definición explícita y coherente de la categoría hablante. Se constata el funcionamiento de una serie de supuestos e ideologías lingüísticas que revelan una conceptualización problemática de dicha categoría, así como la naturalización de relaciones asimétricas en el proceso investigativo, como resultado de enfoques positivistas en la investigación y perspectivas lingüísticas estructuralistas. Se concluye manifestando la necesidad de atender las bases epistemológicas en la categorización de hablantes, así como al objetivo de esta y a sus consecuencias teóricas, ideológicas y de representación de los grupos con quienes trabajamos.
Motivações toponímicas: O ato de nomear bairros populares nas periferias em Angola
Authors: Costa Dinis Fernando da , Daniel Hilton Fortuna
Published: September 2023

RESUMO Este trabalho toponímico da subcategoria da onomástica tem como objetivo investigar a natureza e a motivação do ato de atribuir nomes não oficiais a bairros desenvolvidos em zonas periféricas no período pós-independência, isto é, de 1976 a 2016. O trabalho é o primeiro de um projeto contínuo e avalia um corpus de 34 bairros selecionados em 10 províncias de Angola, com particular destaque para a capital, Luanda. O estudo, que prevalece numa área ainda subdocumentada em Angola, demonstra como o ato de nomear topônimos nas várias cidades do país é caraterizado neste período de pós-independência. Os resultados revelam nomes decorrentes de contextos causa-efeito que refletem uma vivência precária, do ponto de vista social e econômico, o que nos leva a acreditar que a guerra civil, que durou 27 anos, tem sido determinante para que, com base nas motivações dos próprios fundadores, se nomeiem os bairros de cariz popular.
Pourquoi le français? Um estudo de caso sobre ideologias linguísticas
Authors: Sousa Socorro Cláudia Tavares de , Koffmann Rossana Souto Lima , Ponte Andrea Silva
Published: September 2023

RESUMO Este trabalho inserido no campo da Política Linguística (PL) tem como objetivo investigar as ideologias linguísticas sobre a língua francesa (LF) presentes em textos de alunos de francês como língua estrangeira (FLE), em seis escolas de língua, na cidade de João Pessoa. Para atingirmos tal objetivo, analisamos, qualitativamente, as respostas a uma pergunta de um questionário aplicado a 174 alunos, explorando o conteúdo temático e os elementos textuais a partir da Linguística Textual (Koch, 2000a, 2000b). A análise foi realizada conforme os pressupostos teóricos das Ideologias Linguísticas (Del Valle, 2007; Arnoux & Del Valle, 2010; e Del Valle & Meirinho-Guede, 2016). Os resultados indicaram que as ideias sobre a LF apresentam conexões diversas com dimensões sociais: estética - LF como símbolo de elegância e requinte e LF como representativa de uma cultura superior-, epistemológica - LF como língua da ciência -, identidade nacional - LF como língua da França -, identidade internacional - LF como língua da diplomacia - e laboral - LF como língua para o mercado de trabalho.
Elementos de messianismo em pronunciamentos de Jair Bolsonaro
Authors: Brito Clebson Luiz de , Lara Glaucia Muniz Proença
Published: September 2023

RESUMO Este trabalho busca apreender, à luz da semiótica discursiva, elementos do messianismo no discurso de Jair Bolsonaro. Para isso, analisa três pronunciamentos do político realizados respectivamente: a) após a confirmação da vitória nas urnas; b) durante a cerimônia de posse no Congresso Nacional; e c) após o recebimento da faixa presidencial, no Parlatório do Palácio do Planalto. Nesses pronunciamentos, o enunciador reforça os valores do grupo em que se situa, articulando ideias como combate à corrupção, conservadorismo nos costumes, rejeição a minorias sexuais e apelo a identidades religiosas e nacionalistas. Essas ideias, como procuraremos demonstrar, são reafirmadas em torno de uma vitória eleitoral com forte viés messiânico.
Malignant epithelioid mesothelioma in senile Red Sindhi cows from Brazil
Authors: Oliveira Mariana C. , Miranda Ileana , Daoualibi Yasmin , Lopes Samara P. , Pereira Asheley H.B. , Souza Bruno G. , Negrão Watanabe Tatiane T. , Armién Aníbal G. , Ubiali Daniel G. , Brito Marilene F.
Published: September 2023

ABSTRACT: Mesotheliomas in cattle are often described as isolated case reports, and investigations of multiple cases within the same bovine herd are lacking. A series of cases of malignant epithelial mesothelioma, tubulopapilary type, is described in five 15 to 21-year-old Red Sindhi cows from the same herd. Clinical signs included three to eight months of progressive emaciation, dehydration, subcutaneous edema of the lower extremities, and abdominal distension. Grossly, severe subcutaneous edema and hydroperitoneum were noted. Multiple organs’ parietal and visceral serosal surfaces had multifocal to coalescing yellow, firm, sessile nodules ranging from 0.1 to 29.0cm. Similar free nodules floated in the peritoneal fluid. Histologically, the masses comprised a layer of cubic to columnar neoplastic cells forming papillary or cystic proliferation supported by a dense fibrovascular stroma. Neoplastic cells had strong and diffuse cytoplasmic immunolabeling for pan-cytokeratin but were negative for cytokeratin 7 and vimentin. Ultrastructurally, neoplastic cells had delicate microvilli and tight and anchoring junctions. Within the cytoplasm, a moderate amount of loose aggregate of intermediary filament with small mitochondria was observed. Epidemiological investigation evidenced endogamy in this herd. Asbestos exposure was not detected. The diagnosis was based on clinical, gross, histological, and immunohistochemical findings and confirmed by transmission electron microscopy features. A definitive underlying etiology remains unknown.
Fear of COVID-19, food insecurity and anxiety in women dwelling in João Pessoa, Paraíba: a cross-sectional study
Authors: Freire Flora Luiza Pereira do Nascimento , Lima Rafaela Lira Formiga Cavalcanti de , Gomes Nadjeanny Ingrid Galdino , Viana Maria Augusta Correa Barroso Magno , Callou Kátia Rau de Almeida , Vianna Rodrigo Pinheiro de Toledo
Published: September 2023

ABSTRACT Objective: To describe the fear caused by the COVID-19 pandemic and to analyze the association of food insecurity and fear of COVID-19 as anxiety predictors in women who are Sistema Único de Saúde users. Method: A cross-sectional study was conducted in 2021 with 73 women out of 118 who were followed up in a cohort study in the municipality of João Pessoa, Paraíba, Brazil. The women were selected in health units before the pandemic and their telephone contact enabled remote data collection. Socioeconomic and demographic information, food insecurity, fear of COVID-19, and anxiety were assessed. The Brazilian Food Insecurity Scale, the State-Trait Anxiety Inventory, and the Fear of COVID-19 Scale were used. An association between variables was performed using the chi-square test and a logistic regression verified the independent effect of variables concerning anxiety. A 5% significance level was considered. Results: The median age of the women was 33 years and the median per capita family income was BRL 665.33. Most of them lived with a partner and declared themselves mostly black or brown. Lower income and greater severity of food insecurity were associated with greater fear of COVID-19, and this feeling increased the probability of women being in a high anxiety state (OR=3.167). Conclusion: The most vulnerable women, with lower income and greater food insecurity had more fear of COVID-19 which increased their anxiety. Even after the pandemic is over, the effects of these events can maintain a state of mental distress that must be considered and properly cared for.
Sustainable vs circular business models in agribusiness: a comparative bibliometric analysis
Authors: Lamolinara Barbara , Teixeira Mário Sérgio , Marreiros Cristina Galamba , Ferreira Vítor Hugo dos Santos
Published: September 2023

Abstract Agribusiness is using several strategies to achieve sustainable development. The sustainable business models and the circular business models tools are adopted to turn agro-industrial waste into new sustainable products and business opportunities. Even if they are two different tools, the boundary between them is not strictly defined but quite flexible, making it difficult for researchers and stakeholders to discriminate among them. Helping to simplify the understanding of their boundaries, authors purpose to carry out a bibliometric comparative analysis between the sustainable business models and the circular business models in agribusiness. The study aims to underline their different and similar trends in literature. For the analysis, Bibliometrix R-Tool was used and the metadata of two databases (WoS and Scopus) were retrieved and merged. Biblioshiny was used to provide graphical outputs. Data from the two groups were compared in different analysis, such as keywords used, country’s research performance, annual scientific production, among others. It resulted that, although circular business models are more recent in comparison with sustainable business models, both present an increasing publication interest in literature and a similar geographical distribution interest about the issues. However, some interesting differences have been identified, such as the most frequent keywords plus and citation used, among others. These findings can help identify overall trends in circular and sustainable business models in agribusiness, and point out contrasting and common aspects, providing an overview about these research topics in academic literature over time. Additionally, this investigation provides clear outlines and helpful information to researchers, scholars, government managers, industry managers, and consultants.
Overview of stages of change of lean six sigma programs in organizations from 2005 to 2021
Authors: Sousa Eduardo Lopes de , Andretti Fabricio Viana , Castro Marcelo Tadeu Grimaldi de
Published: September 2023

Abstract Quality management can be considered as the set of actions adopted to obtain characteristics of the product or service provided capable of meeting/satisfying needs and even exceeding customer expectations, achieving sustainable results for the organization. In this sense, several improvement programs adopted by organizations have emerged over time, including lean six sigma (LSS). The objective of this research is to establish an overview of the stages of change of the lean six sigma program in organizations in the last 15 years, identifying the critical success factors (CSF) for its implementation before and after these 15 years. The initial panorama was established by carrying out qualitative research with specialists from the LSS program of a service sector organization in 2005, when nine CSF were identified, namely: communication, organizational culture, a commitment of individuals to change, middle managers role, resistance to change, top management commitment, project selection/prioritization, training, and dissemination of results. Then, to analyze the historical evolution, a bibliographic review was carried out on the process of changes in LSS programs in organizations from 2005 to 2021. In this bibliographic review, it was found that the nine CSF identified in the 2005 survey were still relevant in the 15 subsequent years and that technological advances and the digital transformation experienced in various sectors promoted the emergence of three new CSF in the implementation of organizations' LSS programs: big data analytics (BDA), agile manufacturing and innovation.
Quando os controles importam: evidências da associação não linear entre as Deficiências de Controles Internos e a Qualidade de Auditoria
Authors: Marques Vagner Antônio , Vaz Urias Otaviano , Miranda Débora Vieira , Checon Ramon Palaoro
Published: September 2023

RESUMO O objetivo deste estudo foi analisar a associação entre as Deficiências de Controles Internos (DCIs) e a Qualidade de Auditoria (QA). O artigo preenche uma lacuna na literatura nacional, pois apresenta evidências de associação entre as Deficiências de Controles Internos reportadas e as principais proxies de QA. O estudo é relevante porque evidencia a inexistência de associação contemporânea entre as DCIs reportadas e a QA das empresas brasileiras negociadas em bolsa de valores, mas verificou uma associação defasada entre essas variáveis. Diferente dos estudos anteriores, observou-se que as DCIs reportadas no ano anterior podem funcionar como uma Red Flag de Auditoria no ano corrente, contribuindo assim com a avaliação de risco dos contadores, auditores, membros de comitês de governança e da auditoria e reguladores. O estudo, documental e descritivo, com abordagem quantitativa, analisou dados de uma amostra de 257 empresas negociadas na Brasil, Bolsa, Balcão (B3) no período de 2010-2018. Os dados foram avaliados a partir de modelos de regressão com dados em painel, logístico e binomial negativo. Os resultados evidenciaram que, apesar de existirem diferenças significativas entre as proxies de QA das empresas que reportaram DCIs e as que não o fizeram, não há associação contemporânea e estatisticamente significativa entre a divulgação de DCIs e as proxies de QA. Entretanto, observou-se que o audit delay e a probabilidade de envolvimento em um Processo Administrativo Sancionador (PAS) estão associados à quantidade de DCIs reportadas no ano anterior.
Management style in internal audit: influence between personal factors and role conflict
Authors: Ferrari Angélica , Cunha Paulo Roberto da , Boff Marines Lucia
Published: September 2023

ABSTRACT This article analyzes the leader's management style effect on the relationship between personal factors and role conflict in the internal audit function. It sheds light on the factors per se regarding the presence of role conflict in internal audit, addressing the effects that various management styles of the audit leader can cause in the relationship previously addressed in the literature between personal characteristics and role conflict. Evidence shows that the skills and expertise of leading internal audit executives impact the role played by internal auditors, becoming major insights to be analyzed and understood when delimiting the internal audit function. This article contributes to grasping the impact that aspects at a personal, professional, and interaction level in the management hierarchy in companies can have on the internal audit function. A survey was used involving 218 internal auditors certified by the Institute of Internal Auditors of Brazil (Instituto dos Auditores Internos do Brasil [IIA Brasil]), working in the internal audit area and with active profiles on the professional networking platform LinkedIn. Use of multiple linear regression for data analysis. Personal factors encompass the independence and expertise of internal auditors. Role conflict comprises three dimensions: demand from the organization vs. the auditor profession; auditing vs. consulting; and personal values vs. professional expectations. Management style measures the behavior of immediate superiors in the dimensions of task, relationship, and situational context. As results and contributions, it was evidenced that internal auditor’s commitment to independence and expertise have a negative influence on role conflict. A management style with behaviors aimed at relationships between individuals, carrying out tasks, or adapting to situations, on the part of immediate superiors, contributes to reducing the level of role conflict in the internal audit function.
Estilo de gestão na auditoria interna: influência entre fatores pessoais e conflito de papéis
Authors: Ferrari Angélica , Cunha Paulo Roberto da , Boff Marines Lucia
Published: September 2023

RESUMO Este artigo analisa o efeito do estilo de gestão do líder na relação entre os fatores pessoais e o conflito de papéis na função da auditoria interna. Lança-se luz sobre os fatores per se da presença de conflito de papéis na auditoria interna, abordando os efeitos que diferentes estilos de gestão do líder da auditoria podem ocasionar na relação precedentemente já investigada na literatura entre características pessoais e o conflito de papéis. As evidências demonstram que as habilidades e expertise de executivos líderes da auditoria interna impacta o papel exercido pelos auditores internos, tornando-se insights importantes de serem analisados e compreendidos ao delimitar a função da auditoria interna. Este artigo contribui com a compreensão do impacto que aspectos a nível pessoal, profissional e de interação na hierarquia de gestão nas empresas podem ocasionar na função da auditoria interna. Foi usada pesquisa survey envolvendo 218 auditores internos certificados pelo Instituto dos Auditores Internos do Brasil (IIA Brasil), atuantes na área de auditoria interna e com perfis ativos na plataforma de contatos profissionais LinkedIn. Utilização de regressão linear múltipla para a análise dos dados. Os fatores pessoais englobam a independência e expertise dos auditores internos. O conflito de papéis contempla três dimensões: demanda da organização vs. profissão de auditor; auditoria vs. consultoria; e valores pessoais vs. expectativas profissionais. O estilo de gestão mensura o comportamento dos superiores imediatos nas dimensões de tarefa, relacionamento e contexto situacional. Como resultados e contribuições, evidenciou-se que o compromisso com a independência e a expertise dos auditores internos têm influência negativa no conflito de papéis. Um estilo de gestão com comportamentos direcionados ao relacionamento entre os indivíduos, à realização das tarefas ou adaptativo às situações, por parte dos superiores imediatos, contribui para reduzir o nível de conflito de papéis na função da auditoria interna.
Registration with Primary Health Care and COVID-19 mortality: cohort of diabetics from five administrative health regions in the city of Rio de Janeiro, Brazil, 2020–2021
Authors: de Almeida Jéssica Chagas , Paiva Natalia Santana , Gibson Gerusa , Bastos Leonardo Soares , Medronho Roberto de Andrade , Bloch Katia Vergetti
Published: September 2023

ABSTRACT Objective: The present study carried out an analysis of survival according to the status of registration with Primary Health Care (PHC) and of factors associated with death from COVID-19, in cases residing in Programmatic Area 3.1 (PA3.1) with a diagnosis of diabetes (in the notification form or in the electronic medical record), of the Municipality of Rio de Janeiro (RJ), Brazil, in 2020–2021. Methods: A probabilistic linkage of databases was performed based on information on cases notified as COVID-19 and data from the electronic medical records of people living with diabetes. A survival analysis was carried out, using the Cox regression model stratified by age group and adjusted for confounding variables. Results: Individuals registered with the PHC of PA3.1 had almost twice the risk of death from COVID-19 (adjusted hazard ratio [HRadj]=1.91) when compared to those unregistered. This association was stronger in individuals aged 18 to 59 years registered with the PHC (HRadj=2.82) than in individuals aged 60 years or over (HRadj=1.56). Conclusion: Surveillance strategies for identifying and adequately monitoring higher-risk groups, among individuals living with diabetes, within the scope of Primary Health Care, can contribute to reducing mortality from COVID-19.
Colorectal cancer survival in Manizales, Colombia, 2008-2017: a population-based study
Authors: Guzmán-Gallego Eduardo Antonio , Arias-Ortiz Nelson Enrique , Rodríguez-Betancourt Juan David
Published: September 2023

ABSTRACT Objective: To determine 5-year survival in patients with colorectal cancer (CRC) according to patient and tumor characteristics. Methods: Longitudinal study based on incident cases of invasive CRC between 2008 and 2017 captured by the Manizales Population-based Cancer Registry (n=850). Patients were followed up to August 24th, 2021. Cause-specific survival and net survival were calculated for sociodemographic and tumor characteristics, and Cox multivariate was fitted. Results: Fifty-five percent of cases occurred in women. The most frequent histological type was adenocarcinoma (78.2%). The most frequent locations were rectum (32.0%), ascending colon (16.6%), and sigmoid (16.2%). Twenty-five percent of cases were diagnosed in stage IV. There were 567 deaths due to CRC. The 5-year specific survival was 45.8% (95%CI 42.4–49.3), with independent effects for age (HR=1.83; 95%CI 1.26–2.65 age >75 years vs. <50 years) and advanced clinical stage (HR=2.5 and HR 5.7 for stages III and IV vs. stage I, respectively). Lower survival was observed in patients of medium socioeconomic status compared with higher socioeconomic status (HR=1.52; 95%CI 1.08–2.14), but not in patients of low socioeconomic status. No independent effects were observed for the health insurance regime. Conclusions: In Manizales, approximately 5 out of 10 patients with invasive CRC die in the first five years after diagnosis, with a lower survival in patients older than 75 years, from medium socioeconomic level and diagnosed in advanced clinical stages.
Supervivencia al cáncer colorrectal en Manizales, Colombia, 2008-2017: un estudio de base poblacional
Authors: Guzmán-Gallego Eduardo Antonio , Arias-Ortiz Nelson Enrique , Rodríguez-Betancourt Juan David
Published: September 2023

RESUMEN Objetivo: Estimar la supervivencia a 5 años en pacientes con cáncer colorrectal (CCR) según características del paciente y del tumor. Métodos: Estudio longitudinal a partir de los casos de CCR invasivo diagnosticados entre 2008 y 2017 captados por el Registro Poblacional de Cáncer de Manizales (n=850). Se realizó seguimiento hasta el 24 de agosto de 2021. Se calculó la supervivencia causa-específica y la supervivencia neta para las características sociodemográficas y del tumor, y análisis multivariado de Cox. Resultados: El 55,5% de los casos se presentaron en mujeres. El tipo histológico más frecuente (78,2%) fue el adenocarcinoma. Las localizaciones más frecuentes fueron recto (32,0%), colon ascendente (16,6%) y sigmoides (16,2%). El 25,5% de los casos fue diagnosticado en estadio IV. Ocurrieron 567 muertes por CCR. La supervivencia específica a 5 años fue del 45,8% (IC95% 42,4–49,3), con efectos independientes para la edad (HR=1,83; IC95% 1,26–2,65 edad >75 años vs. edad <50 años) y el estadio clínico avanzado (HR=2,5 y HR 5,7 para estadios III y IV vs. estadio I). Se observó una menor supervivencia en pacientes de nivel socioeconómico medio en comparación con el grupo de mayor posición socioeconómica (HR=1,52; IC95% 1,08–2,14), pero no en los pacientes de posición socioeconómica baja. No se observaron efectos independientes para el régimen de aseguramiento en salud. Conclusiones: En Manizales, aproximadamente 5 de cada 10 pacientes con CCR invasivo fallecen en los primeros cinco años del diagnóstico, con sobrevida menor en pacientes mayores de 75 años, de nivel socioeconómico medio y diagnosticados en estadio clínico avanzado.
Time series of cases and treatment outcomes from tuberculosis in Sergipe, 2012–2021
Authors: Batista Jefferson Felipe Calazans , Santos Vitória Steffany de Oliveira , Jesus Carla Viviane Freitas de , Lima Sonia Oliveira
Published: September 2023

ABSTRACT Objective: The objectives of this study were: (1) to analyze the temporal trend of tuberculosis treatment outcomes in the state of Sergipe; (2) to identify the existence of seasonality of tuberculosis; (3) to verify the influence of the rapid molecular test (MTB-RIF) in the time series of tuberculosis and its treatment outcomes in the state of Sergipe; and (4) to verify treatment outcomes. Methods: Ecological study on tuberculosis and three treatment outcomes (cure, interruption of treatment, and death) extracted from Datasus. Incidence and mortality rates were calculated for the crude occurrences of cases and deaths and the proportions of cure and interruption of treatment (%). The time series was analyzed using Prais-Winsten regression from Jan to Dec/2021. Results: The total incidence rate was 36.35 cases per 100,000 inhabitants, with an increase of 0.44% per month (95%CI 0.35; 0.54). The cure rate was 64.0% with a steady trend (p>0.05). The percentage of treatment interruption was 13.3%, with a reduction of −0.73%/month (95%CI −1.11; −0.34). The total mortality rate was 1.92 deaths/100,000 inhabitants with a stationary trend. After the implementation of the MTB-RIF, there was an increase in the incidence rate of 0.65% per month. Seasonality was not identified in any of the analyses performed (p>0.05). Conclusion: There was an increase in incidence rates, reduction in treatment interruption and mortality in the state of Sergipe. Seasonality was not identified. The rapid molecular test showed a growth effect on the incidence rate.