bluuebunny/crossref_metadata_2025 huggingface dataset:
Small and medium towns of nizhegorodskoe povolzhie region: in search of the lost harmony. Part 2
Authors: Lisitsyna Alexandra V.
Published: June 2024

The second part of the article highlights the processes of historical and architectural environment transformation in small and medium-sized towns of the Nizhegorodskoe Povolzhie region during the Soviet and post-Soviet periods. The author analyzes the factors that led to the loss of architectural landscapes visual harmony that had developed by the beginning of the 20th century. The historical and architectural environment is interpreted as a phenomenon of the region architectural and urban culture. It is considered in the context of topical historical and theoretical problems of architecture and urban planning: problem of traditions and innovations; problem of mass and unique; problem of style and image; problem of global and identical. The general regularities of the historical and architectural environment formation and development throughout the life cycle of the New and Newest times are investigated.
Conceptual strategies in the works of Rem Koolhaas
Authors: Danilova Elina V.
Published: June 2024

The article is devoted to the key concepts in Koolhaas’s work. The article discusses the concepts implemented by the architect when developing a functional program, spatial structure, and architectural form. Various objects created by applying these concepts are analyzed. Many examples are given to illustrate Koolhaas’s original method. Features of the application of concepts that ensure the uniqueness of the design solution in each object are revealed, when using similar design tools. Particular attention is paid to the evolutionary development of concepts ▪ from their theoretical basis and experimentation in early projects to their consolidation in symbolic patents as architectural inventions.
Development of science in the space of russian capitals: The beginning of the Way
Authors: Frezinskaya Nataliya R. , Sergeev Kirill I.
Published: June 2024

The article examines the processes of the formation of science in the space of Russian capitals. The features of the formation of networks of scientific objects in capital cities are noted: established (Moscow) and new (St. Petersburg). The formation of each network is considered against the background of the development of the city’s planning structure. The influence of production process technology on the selection of sites suitable for scientific research is shown. The reasons for the concentration of scientists in the Moscow territorial area “Kremlin ▪ Kitai-Gorod” and St. Petersburg “Vasilievsky Island” are determined. Materials are presented that characterize the development of communication between scientific institutions and educational institutions, manufacturing enterprises and other urban facilities that use the results of research work in their activities. Attention is paid to the problem of resettlement of scientists, production workers, teachers and students, organization of relatively independent towns within urban areas. The changes that the spatial organization of science underwent in the cities under consideration during the 17th and 18th centuries are analyzed.
Infección por SARS-CoV-2 en el embarazo: características clínicas y trasmisión vertical en un hospital de referencia de Perú
Authors: Urbina-Alvarez Claudia Aracelli , Sifuentes-Alvarez Julio Cesar , Moreno-Bocanegra Juan Felipe , Vasquez-Sandoval Kevin , Huiza- Espinoza Lilia , La Rosa-De los Rios Mauricio , Gomez De La Torre-Pretell Juan Carlos , Barletta-Carillo Claudia Fiorella
Published: June 2024

The study carried out in the Department of Gynecology and Obstetrics of the Edgardo Rebagliati Martins National Hospital (HNERM) aimed to analyze the vertical transmission of the SARS-CoV-2 virus in pregnant women with COVID-19. Twelve pregnant women who met the established inclusion criteria were included. Real-time PCR (RT-PCR) diagnostic testing for SARS-CoV-2 was performed during the admission of each pregnant patient, and placenta samples were collected for pathological evaluation. The results showed that vertical transmission of the virus was rare, with an overall low positivity rate in newborns. Although the study has limitations, such as the small number of cases and the lack of electron microscope analysis, it constitutes the first attempt in Peru to evaluate vertical transmission. It is concluded that more research is needed to better understand the relationship between COVID-19 infection and complications during pregnancy.
Development of Obstacle Avoidance Control System Using Modified Attractive Equations of Gaussian Potential Function
Authors: Saenrit Kanapat , Phaoharuhansa Danai
Published: June 2024

Navigation system is a necessary system for autonomous vehicle and many papers proposes the techniques for trajectory tracking and obstacle avoidance. Gaussian potential function is well-known for trajectory tracking control system with obstacle avoidance using 2D lidar. The disadvantage is that it relies on local minima, which is unable to deviate the moving path in some cases that vehicle and target is moving in the same direction, and obstacle is in between because the temptation of attractive potential field is too high. Then, the trajectory tracking control with obstacle avoidance using a modified attractive function has been introduced that conventional attractive function of gaussian potential function is modified in order to improve the navigation system. The simulation is performed by CARLA Simulator and the motion of the obstacle avoidance using the modified function is considered by the sway motion during the tracking and the safety during the lateral motion, which is considered by lateral acceleration of the vehicle, its value in simulation case is less than other types of attractive function. Meanwhile, the modified function also maintains the safety distance gap between the vehicle and the obstacle to not avoid at very close range from obstacle, which probably cause the collision.
Breaking through mandibular barrier: A case report on orthodontic repositioning of an impacted tooth
Authors: Nandan Hemwati , Reddy Srinivas Gosla , Jha Pragjyoti
Published: June 2024

Tooth impaction is known to cause various problems such as space loss, tipping of adjacent teeth, super-eruption of the antagonist tooth, and dislocation of the permanent tooth beneath the impacted primary tooth. In this case report, we present the treatment of a 14-year-old female patient who presented with a chief complaint of missing teeth in the lower left back jaw region. OPG finding reveal the exceptional occurrence of simultaneous impact ion involving the primary second molar and its succedaneous teeth- a remarkable rare observation. Based on the CBCT findings, it was revealed that the impacted premolar had ruptured the lower border of the mandible. To address this issue, a comprehensive treatment plan was developed. The treatment plan included the use of a bonded appliance to create space for tooth eruption, followed by surgical removal of the primary molar to provide more room for the impacted premolar. A traction chain was then attached from a fixed orthodontic appliance to the impacted premolar, guiding it into the correct position. Throughout the treatment process, the patient was closely monitored for any signs of discomfort or complications, and necessary adjustments were made to ensure the best possible outcome. The combination of these techniques proved to be effective in achieving successful orthodontic treatment and improved dental health for the patient.
Role of Recombinant Proteins for Treating Rheumatoid Arthritis
Authors: SasaniSasani Mahboubeh Soleimani , Moradi Yeganeh
Published: June 2024

Rheumatoid Arthritis (RA) is an autoimmune disease and chronic inflammatory disorder that affects joints and causes inflammation, pain, stiffness, and eventually progressive joint destruction. Approximately 1% of the world's population is estimated to suffer from RA, and if this disease is left untreated, it can lead to severe disability. Despite all the efforts and advances made by professionals in the field, there is currently no definitive treatment for RA, and most treatment strategies are aimed at relieving symptoms and improving patients' quality of life. One of the most promising current approaches is the use of recombinant proteins that target specific signaling pathways involved in the development of RA to alleviate symptoms and slow the progression of the disease. This article discusses the genetic and immunological factors that influence the development of RA, recombinant proteins, methods of using these proteins, approved drugs, and side effects associated with treating RA.
Evaluation of the Spatial Arrangement of Rabbit Hepatocytes Based on Voronoi Tessellation Following Exposure to Zinc Oxide Nanoparticles
Authors: Moasses Zia , Aryan Arefeh , Mesbah Fakhroddin , Mirzaei Esmaeil
Published: June 2024

Background: Zinc oxide nanoparticles have been utilized in different fields over the last decades. These nanoparticles can pose significant risks to various organs such as the liver. This study aimed to evaluate the effects of zinc oxide nanoparticles on liver histology, serum biochemistry, and spatial arrangement of the hepatocytes in the female New Zealand white rabbit.
Methods: The rabbits received 1, 5, and 10 mg/kg of the zinc oxide nanoparticles (ZnO NPs) intraperitoneally once every 3 days for 28 days. The serum levels of the aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and zinc were assessed 48 hr following the first administration. The histopathological changes and Voronoi tessellation were evaluated after the last administration.
Results: Our findings showed that the ZnO NPs significantly increased the serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and zinc. The histopathological findings showed ballooning degeneration, and sinusoidal congestion in ZnO NPs administrated groups. The Voronoi tessellation diagrams also confirmed that ZnO NPs changed the regular spatial arrangement of hepatocytes to random and cluster patterns.
Conclusion: In conclusion, the ZnO NPs alter the liver spatial arrangement and induce hepatic pathological changes that may affect liver function in rabbits
Studying the Effect of Magnetron Copper Deposition on the Surface Topography of Biodegradable Antibacterial Coating
Authors: Bauyrzhan Maratuly , Azamatov Bagdat Nurlanovich , Jes Alexey Vladimirovich
Published: June 2024

Background: The surface properties of the materials used significantly influence the success and longevity of medical implants. Increasing surface roughness promotes osteoblast activity and osseointegration, while biodegradable materials such as copper have shown potential for antimicrobial applications. However, the effect of coating parameters on surface topography is not well investigated.
Methods: Sputtering of copper was performed using EPOS-PVD-440 system (Zelenograd, Russia). The samples were examined by Scanning Electron Microscopy (SEM) with subsequent image processing in Mountains software (Digital Surf). Antibacterial efficacy was evaluated against Staphylococcus aureus by measuring the zone of inhibition. Additionally, copper ion release was monitored over time to assess its correlation with changes in surface topography.
Results: Higher sputtering currents increased surface roughness and particle size, with a significant release of copper ions within the first 24 hr of immersion. Samples sputtered at higher currents exhibited coarser grain structures. The release of copper ions in the simulated biological environment led to further changes in surface topography, highlighting the critical influence of sputtering parameters on coating properties.
Conclusion: Optimizing magnetron copper deposition parameters enhances the surface topography and antibacterial effectiveness of biodegradable coatings on implants.
Lippia multiflora Leaves Extracts Enhance Cefotaxime Bactericidal Effects and Quench the Biofilm Formation in Methicillin-Resistant Staphylococcus aureus ATCC 43300
Authors: Rouamba Ablassé , Badini Djaouratou , Compaoré Eli , Ouédraogo Vincent , Kiendrebeogo Martin
Published: June 2024

Background: The emergence of the multidrug-resistant bacteria strain has become a global world crisis. This study was designed to evaluate the antibiofilm and synergistic effects of Lippia multiflora leaf extracts on the activity of cefotaxime against the methicillin-resistant Staphylococcus aureus (S. aureus).
Methods: The synergistic effect of methanol and dichloromethane extracts on the bactericidal activity of cefotaxime was determined by using the antibiotic susceptibility test on agar medium. The antibiofilm activity of the extracts was measured by using the crystal violet method. The antioxidant potential of the extracts was assessed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reduction Activity Potential (FRAP) methods. The main secondary metabolites groups were analyzed by using different standard analytical tests. The total phenolics and total flavonoids were quantified spectrophotometrically.
Results: The methanol extract (final concentration of 100 µg/ml) inhibited the formation of bacterial biofilm more than salicylic acid (p<0.05). All extracts combined with cefotaxime (20 µg and 200 µg) showed good synergistic bactericidal effect on S. aureus with inhibitory diameters of up to 40 mm. The methanol extract showed higher total phenolics (462.20±10.90 mg EAG/g) and total flavonoids (26.20±0.20 mg EQ/g) contents than the dichloromethane extract (96.70±1.70 mg EAG/g and 8.00±1.20 mg EQ/g). Moreover, the methanol extract showed a higher FRAP reducing power (353.6± 4.17 mmol EQ/g) than the dichloromethane extract (385.3±7.01 mmol EQ/g). Qualitative phytochemical analysis showed the presence of tannins, flavonoids, terpenes and sterols in both extracts.
Conclusion: These data showed that L. multiflora leaves contain effective antibacterial phytomolecules for combating bacterial resistance.
Predictors of Mortality among Intensive Care Unit (ICU) Hospitalized Diabetic Patients with COVID-19
Authors: Jelodar Mohsen Gholinataj , Mirzaei Samaneh , Maghsoudi Majid Haji
Published: June 2024

Objective: Diabetic patients with COVID-19 are at the higher risk of clinical complications and intensive care unit (ICU) admission. There is limited information available on the risk factors of mortality in diabetic patients with COVID-19 admitted to the ICUs. The aim of this study was identifying the mortality risk factors in diabetic patients with COVID-19 who are admitted to the ICU.
Materials and Methods: In this study, we conducted a descriptive-analytical observational analysis on 391 patients admitted to the ICU for 18 months. We assessed the demographic, clinical, pharmaceutical, laboratory and imaging data of diabetic patients and statistically analyzed them to identify mortality risk factors.
Results: The study found 156 (39.89%) diabetic out of 391 patients. The group of diabetic patients had significantly higher rates of endotracheal intubation (P< 0.001), mortality (P< 0.001), and complications during hospitalization due to COVID-19, including secondary bacterial infections (P =  0.005), venous thrombosis (P = 0.008), and gastrointestinal bleeding (P = 0.011), compared to the nondiabetic patient.
Conclusion: Patients with diabetes who also have COVID-19 tend to experience more severe clinical outcomes and a higher mortality rate when admitted to the intensive care unit. The likelihood of mortality in these patients is closely associated with factors such as stroke occurrence, oxygenation levels, and the presence of secondary infections at the time of admission.
Antibody Engineering to Enhancement of Ranibizumab Binding Affinity for the Prevention and Treatment of Diabetic Retinopathy
Authors: Sefid Fateme , Monshizadeh Kimia , Azamirad Ghasem , Vahidi Mehrjardi Mohammad Yahya
Published: June 2024

Objective: The VEGF function blockage effectively reduces the progression of diabetic retinopathy. Ranibizumab and bevacizumab are some anti-VEGF monoclonal antibodies (mAb). Considering the importance of affinity maturation of ranibizumab, we aimed to find the essential amino acids of the ranibizumab antibody (Ab).
Materials and Methods: We tried to find the important amino acids of this antibody via Paratome, Meta-PPISP, and the WESA web server. Subsequently, these amino acids were mutated to improve the binding affinity of the Ab variants to antigen (Ag). In this regard, the ranibizumab anti-VEGF-A was mutated. The structural docking prediction of the ranibizumab-VEGF-A complex was used for the design and validation of ranibizumab with a higher affinity for binding to VEGF-A. Finally, we measured the binding affinity of Ab variants to Ag by computational docking.
Results: Bioinformatic analyzes such as molecular docking and dynamics showed that several mutant variants successfully improved the properties of Ab binding compared to the wild-type Ab.
Conclusion: Consistent with the use of anti-VEGF monoclonal antibodies in the treatment of diabetic retinopathy, the mutant variants of ranibizumab may be potential candidates for stronger affinity binding to VEGF, which may affect the specificity and sensitivity of the antibody.
Genetic and Epigenetic Etiologies of Type 1 Diabetes Mellitus
Authors: Yahaya Tajudeen , Obaroh Israel , Magaji Umar , Obadiah Caleb , Anyebe Daniel , Shemishere Ufuoma
Published: June 2024

Numerous suspect genes associated with type 1 diabetes mellitus (T1DM) have been identified, suggesting a need to focus on the disease's causal genes and mechanisms. This necessitates an update to raise public awareness. This review articulates genes with mutations that predispose individuals to T1DM. We conducted a comprehensive search of academic databases, including Web of Science, Scopus, PubMed, and Google Scholar, for relevant materials. Available information indicates that at least 70 genes are suspected in the pathogenesis of T1DM. However, the most frequently implicated genes include human leukocyte antigen (HLA), insulin (INS), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and protein tyrosine phosphatase non-receptor type 22 (PTPN22). Mutations or variants in these genes may lead to insulin insufficiency and, consequently, T1DM by tricking immune cells, such as T-cells and B-cells, into attacking self-antigens and triggering the autoimmunity of beta cells. Furthermore, this pathophysiology can be mediated through aberrant epigenetic modifications, including DNA methylation, histone post-translational modifications, and noncoding RNAs, in the mentioned genes. Some of these pathophysiologies are gene-specific and may have an epigenetic origin that is reversible. In the event of an epigenetic origin, a treatment for T1DM that addresses the causal genes or reverses epigenetic changes and their mechanisms could yield improved outcomes. Medical professionals are encouraged to design therapeutic regimens that specifically target the mentioned genes and address the identified epigenetic alterations in individuals expressing such etiologies.
Endometrial scratching in unexplained repeated implantation failure causes two competing forces, angiogenesis and anti-angiogenesis: An RCT study
Authors: Aghajanpour Samaneh , Mehraein Fereshteh , Amjadi Fatemehsadat , Zandieh Zahra , Ghaffari Firouzeh , Aflatoonian Khashayar , Hosseini Elham , Bakhtiyari Mehrdad , Aflatoonian Reza
Published: June 2024

Background: A significant association between endometrial vascularity and pregnancy has been shown in previous research, while poor vascularization was attributed to repeated implantation failure (RIF). One possible approach to enhance angiogenesis for successful implantation is endometrial scratching (ES).
Objective: The purpose was to investigate endometrial responses to scratching by profiling angiogenesis-related gene expression in unexplained RIF participants.
Materials and Methods: In this randomized controlled trial study, 20 infertile women with unexplained RIF were assigned to 2 groups by the balanced block randomization method (n = 10/each group): the intervention group (group A) (who received ES in the follicular phase) and the control group (group B). Endometrial biopsy was performed in the secretory phase. Gene expression profiling was performed using a polymerase chain reaction-array kit for humanangiogenic growth factors. The implantation and clinical pregnancy rates were also assessed.
Results: Among the angiogenesis-promoting genes, FGF1, FGF13, FGF2, TGFA, ANG, ANGPT1, and VEGFA were significantly upregulated (p < 0.05). IL12A (an angiogenesis-inhibiting cytokine) was significantly upregulated (p < 0.01). In contrast, 15 genes with angiogenesisrelated functions, including CXCL11, CXCL13, CXCL3, CXCL5, CXCL6, EREG, FIGF, FST, IL10, LEP, PPBP, PROK1, RHOB, TNF, and TYMP, were downregulated after ES. No significant differences were observed between the intervention (group A) and control (group B) groups in terms of implantation (43.75% vs. 28.57%) or clinical pregnancy rates (75% vs. 57.1%).
Conclusion: ES induced significant alterations in the expression of angiogenesis-related genes, with notable up/downregulation of key angiogenic/antiangiogenic factors. These findings enhance our understanding of the molecular responses triggered by ES, underscoring the potential influence of ES on the complex processes of angiogenesis crucial for implantation.
Key words: Endometrium, Angiogenesis, Embryo implantation, Polymerase chain reaction.
The effect of Henna (Lawsonia inermis) vaginal suppository combined with antibiotic therapy in the treatment of cervicitis: An RCT
Authors: Nabimeybodi Naeemeh , Nokhostin Fahimeh , Zareshahi Rahele , Kamalinejad Mohammad , Akhundimeybodi Hedayat , Madadizadeh Farzan , Meybodi Mohsen Nabi , Mazraeno Narges Seifi , Nabimeybodi Razieh
Published: June 2024

Background: Cervicitis is a prevalent gynecologic disease, which does not usually respond to conventional treatments. Long-term cervicitis can cause serious health problems such as inflammation, infertility, and cancer. Henna oil, an herbal product in Persian medicine, is recommended for uterine diseases like cervicitis.
Objective: This study aims to evaluate the efficacy of Henna oil as a vaginal suppository in combination with an antibiotic regimen in the treatment of cervicitis.
Materials and Methods: This randomized placebo-controlled trial, included 92 nonmenopausal women with cervicitis at the Baqaipur Clinic of Shahid Sadoughi hospital in Yazd and the Persian Medicine Health Center in Ardakan, Yazd, Iran. Participants were further divided into either the Henna oil vaginal suppository group or the placebo group (n = 46/each group). During the study, the antibiotic treatment was administered to both groups. Cervicitis symptoms were compared between the groups and within each group. Results: Of 92 included individuals, 41 in each group completed the study.
Results: revealed that significant differences were observed in some outcomes, including vaginal discharge (p < 0.001), cervical ulcer size (p < 0.001), dyspareunia (p = 0.046), and postcoital bleeding (p < 0.001), indicating that the treatment was more effective in the henna group compared to the placebo group.
Conclusion: Findings supported that the vaginal suppository of Henna oil in combination with antibiotic therapy could be effective in the improvement of clinical symptoms of cervicitis regardless of its pathology.
Key words: Lawsonia inermis, Persian+traditional medicine, Uterine cervicitis, Infertility, Vaginal suppository, Clinical trial.
Changes in menstrual cycles among Iranian women during the COVID-19 pandemic: A cross-sectional study
Authors: Ranjbar Fahimeh , Haghani Shima , Aghashahi Motahareh , Gharacheh Maryam
Published: June 2024

Background: Some women experienced alterations in their menstrual cycles during the Coronavirus disease 2019 (COVID-19) pandemic.
Objective: This study aimed to evaluate the changes in menstrual cycles among Iranian women during the COVID-19 pandemic.
Materials and Methods: This cross-sectional study included 1500 women of childbearing age referred to healthcare centers in Tehran, Iran from April-November 2022. Participants were selected using the stratified sampling method. Data were collected via a questionnaire covering information on menstrual cycle, COVID- 19 infection, and COVID-19 vaccination status. The study’s outcomes focused on menstrual changes by evaluating cycle regularity, duration, and symptoms based on participant-reported observations.
Results: The findings revealed that the pattern of menstrual change during the pandemic occurred in the form of a shorter interval in 8.6%, and longer interval in 8.9%, shorter duration in 10.4%, longer duration in 9.4%, heavier bleeding in 12.3%, lighter bleeding in 14.7%. The chance of menstrual changes in women who were infected with COVID-19 was 54% higher than that of women who were not infected, and the chance of menstrual changes in women who received 3 doses of COVID-19 vaccine was 1.5 times higher than women who had not been vaccinated.
Conclusion: Our research revealed a high incidence of menstrual changes among Iranian women of childbearing age during the COVID-19 pandemic. Healthcare providers should be knowledgeable about the menstrual changes associated with COVID-19 infection and vaccination to provide information and support to affected women.
Key words: Menstrual cycle, Menstrual irregularities, COVID-19, Vaccine.
Comparison of serum levels of interleukin 33 in combination with serum levels of C-reactive protein, Immunoglobulin G, Immunoglobulin A, and Immunoglobulin M in recurrent pregnancy loss: A case-control study
Authors: Khazaei Hossein Ali , Farzaneh Farahnaz , Sarhadi Saeedeh , Haghighi Javid Dehghan , Forghani Forough , Sheikhi Vahid , Khazaei Bahman , Asadollahi Lida
Published: June 2024

Background: One of the critical cases of recurrent pregnancy loss is immunological factors, whereas obtaining effective prevention or treatment is necessary for cognition of reasons. Objective: In this study, we tried to evaluate some immunological factors related to recurrent pregnancy loss.
Materials and Methods: This case-control study was conducted on 66 women at the age of 18–35 yr who were referred to the Clinic of Gynecology and Obstetrics, Ali Ibn Abi Taleb hospital, Zahedan, Iran, from August-December 2019. Interleukin 33 (IL-33) serum levels were measured using enzyme-linked immunosorbent assay. Immunoglobulin G, Immunoglobulin A, Immunoglobulin M (IgM), and C-reactive protein levels were measured by serology and hematology methods.
Results: The mean age of total participants was 30.8 ± 3.80 yr. The mean serum IL-33 in the case group was 318.5± 254.1 pg/ml and was lower than the control group (354.2± 259.9 pg/ml), which was not statistically significant (p = 0.52). The level of C-reactive protein in the case and control was not significantly different (p = 0.27), and Immunoglobulin A and Immunoglobulin G in the case and control were also not significantly different) p = 0.46, and p = 0.16, respectively), but there were significant differences (p= 0.003) between the level of the IgM in the case and control groups.
Conclusion: No statistically significant difference was observed in the IL-33 serum level, for at least 4–6 months after the last abortion in the case group and the final live birth in the control group. In contrast, serum levels of IgM were statistically significant. Finally, the need for more studies is felt according to the different results of the previous studies in this field.
Key words: Interleukin-33, Abortion, IgG, IgA, IgM.
The report of ovarian tissue transplant in Iran: A case report
Authors: Anbari Fatemeh , Khalili Mohammad Ali , Vatanparast Mahboubeh , Haghdani Saeid , Eftekhar Maryam
Published: June 2024

Background: Cancer treatments such as chemotherapy and radiotherapy increase the chance of ovarian failure. Ovarian tissue transplantation (OTT) is a viable option for fertility preservation in these cases. We aim to report ovarian transplantation in a leukemia case undergoing the vitrification method.
Case Presentation: The case was a 28-yr-old female in Research and Clinical Center for Infertility, Yazd, Iran who was suffering from leukemia. Ovarian biopsy was performed by laparoscopy surgery and transported to cryopreservation lab at 4°C for 1–2 hr. The ovarian cortex was removed from the medulla, and ovarian strips were cryopreserved by vitrification. This procedure used the equilibration and vitrification solutions including medium 199 supplemented with 20% serum, and ethylene glycol and dimethyl sulfoxide with concentrations of 7.5% and 20%, respectively. Before doing OTT, we assessed the tissue viability and follicular count by chick embryo chorioallantoic membranes and histologic survey, respectively. OTT was done after complete remission, following warmed tissue sutured together and transplanted on the residual medulla on the right side. On the left side, the ovary was removed completely; however, 2 strips were put on the peritoneal pocket. Anti-Müllerian hormone, follicle-stimulating hormone, and luteinizing hormone levels were 0.1 ng/mL, 36.5 mIU/mL, and 19.8 mIU/mL before OTT. During a 6-month follow-up, the anti-Müllerian hormone increased to 0.9, and then follicle-stimulating hormone and luteinizing hormone levels decreased dramatically until 17.47 mIU/mL and 6.71 mIU/mL, respectively. Also, the patient had 3 cycles of menstrual periods.
Conclusion: We demonstrated an appropriate hormonal profile, and the restoration of the menstrual cycle might indicate a successful transplant. Further investigations are needed to achieve successful clinical outcomes.
Key words: Cryopreservation, Tissue transplantation, Leukemia, Vitrification, Ovarian follicle.
Innovation in Government: Strategies for Effective Public Service Delivery
Authors: Saragih Jopinus
Published: June 2024

This study aims to identify and analyze the factors that drive and hinder innovation in the public sector. The goal is to understand how these factors influence the quality of public service delivery and provide practical recommendations for policymakers and practitioners in the public sector. The study focuses on the public sector in North Sumatra Province, Indonesia, to offer context-specific insights. The research adopts a quantitative approach using survey methods. The sample consists of 300 public sector employees from various departments within the North Sumatra Provincial Government, selected through purposive sampling. Data collection involved questionnaires designed to measure factors driving and hindering innovation, as well as interviews with key personnel to gain deeper insights. The data were analyzed using descriptive statistics, regression analysis, and thematic analysis. This study underscores the critical role of management support, technological access, and a supportive organizational culture in promoting innovation in the public sector. It also highlights significant barriers such as resistance to change, resource constraints, and rigid bureaucracy. Addressing these barriers through comprehensive and strategic approaches, including bureaucratic reform and effective communication, can create an environment conducive to innovation. This, in turn, can enhance the quality of public services and meet the increasingly complex needs of society. The findings provide valuable insights for policymakers and public sector managers aiming to foster sustainable innovation and improve public service delivery.
Gender Differences in Moral Distress and Ethical Conflict: A Survey of Indian Veterinary Practitioners
Authors: Singh Davinder , Shunthwal Jyoti , Gowane G.R. , Khanna Sujoy
Published: June 2024

Background: Gender differences are steadily increasing in the moral distress and ethical conflict of practicing veterinarians internationally and little research has been done to identify the root causes of these problems. Gender differences in ethical conflict and resultant moral distress may lead to decreased job satisfaction in one specific gender. Methods: A mixed-methods sequential explanatory methodology was used to conduct this study on randomly selected Indian veterinary practitioners. The survey was conducted between April 2022 and March 2023. Result: The study found that only 426 veterinarians participated in the survey, with responses analyzed for demographic characteristics and training of respondents, causes of ethical conflict and moral distress levels and coping methods. The majority of respondents were male and worked in State Services. Female respondents reported less conflict resolution training and less training on self-care. The causes of ethical conflict varied, with some respondents reporting frequent disagreements with animal owners regarding their preferred course of treatment. Coping mechanisms included discussion with colleagues and seniors, seeking professional help and discussing with a partner or friend.
Phytochemical Screening and Antibacterial Activity of Some Extracts from Atriplex halimus Growing in Algerian Sahara
Authors: Berreghıoua A. , Ziane L.
Published: June 2024

Background: Natural products possess interesting biological activities, which attracted several researchers to their elucidation to provide knowledge that will lead to the advancement medicine. Chenopodaceae is an important plant family in the world; it contains a number of phytochemicals and has been used to treat a wide range of human diseases. The aim of this work was to carry out qualitative analyses of secondary metabolites and an antimicrobial investigation on the crude extracts from Atriplex halimus (Chenopodaceae) growing in Algerian Sahara. Methods: In this laboratory investigation during 2021-2022, phytochemical screening based on staining and precipitation tests was carried out using some solvents of different polarities. The antibacterial essay was carried out by the disc diffusion method on solid medium, using seven bacterial strains chosen for their high pathogenicity. Result: The secondary metabolites detected in the various extracts were essentially flavonoids, tannins, saponins and terpenoids. The antibacterial investigation made it possible to know that the aqueous extract from Atriplex halimus showed a significant inhibition against all bacteria tested. Diethyl ether and chloroform exracts had only one activity against Enterococcus faecalis and Listeria monocytogenes, respectively, whereas the methanolic extract exhibited the highest inhibition of Pseudomonas aeruginosa.
Income differentials among migrants by race/color in Brazil-2000/2010
Authors: Pereira de Souza Joice , da Silva Filho Luís Abel
Published: June 2024

Individuals’ socioeconomic and demographic characteristics influence salary discrepancies arising from work. Given this, this article aims to investigate income differentials between inter-municipal migrants, dividing them into two specific groups: non-whites and whites, based on microdata from the Demographic Censuses of the years 2000 and 2010. Initially, the empirical literature on labor income differentials is reviewed. Then, a Mincerian income equation is used, estimated by Ordinary Least Squares, in order to analyze wage inequalities among migrants. The results showed that white migrants earned significantly higher incomes than non-whites and that the characteristics of those employed had a different influence between the groups. However, it was found that these inequalities reduced over time.
Equidad y trabajo sexual: un análisis a la luz de los determinantes sociales de la salud
Authors: Betancurth Loaiza Diana P. , Vélez Álvarez Consuelo , Sánchez Palacio Natalia , Jaramillo Ángel Cluadia P.
Published: June 2024

Existe un contexto de desigualdades sociopolíticas y necesidades insatisfechas para ejercer el trabajo sexual, lo que configuran una injusticia extrema. El objetivo de este artículo es analizar los determinantes sociales de la salud que generan inequidad en la población trabajadora sexual de una ciudad colombiana. Se utilizó una investigación cuantitativa con un enfoque asociativo, y la población fue de 131 trabajadoras sexuales cisgénero y transgénero. Se realizó muestreo por bola de nieve, la información se ingresó en el sistema del Observatorio de Género y fue procesada y analizada con SPSS. Entre los resultados se desataca que la edad promedio fue de 34,24 ± 9,610 años, rango 18 y 61 años. El 59,6 declaró ser soltero, un 7,6% no tenía estudios, y un 29,8% únicamente educación primaria. El 15% no se encuentra afiliado a salud, y un 96,9% informó ingresos inferiores a un salario mínimo mensual. Esto refleja la vulnerabilidad, la inequidad y los desafíos en diversas dimensiones del desarrollo humano. Las condiciones de educación, salud y empleo fueron los determinantes sociales que generan mayor inequidad, por ende, la formulación de políticas públicas en beneficio de las trabajadoras sexuales permitirá abordar estos desafíos con miras a garantizar acceso adecuado a servicios de educación, salud y derechos laborales, con el empoderamiento de este grupo que ha sido vulnerado para mejorar su calidad de vida.
The Legal Culture of Samin Community of Family Law in Central Java
Authors: Nur Wakhidah  , Zulfa Jamalie  , Mujiburohman Abas  , Raihanah Abdullah  , Jalaluddin Jalaluddin
Published: June 2024

This article seeks to examine the legal culture of the Samin community in relation to their preferences in family law, the persistence of the customary law in the community, and the transformations that have taken place in Samin family law. The data of this article is derived from an ethnographic study conducted at various Samin villages in Central Java between 2022 and 2023. Information was gathered via in-depth interviews, observation, and document analysis. The study's findings suggest that the government does not officially recognize marriage within the Samin community. However, the Samin family law has undergone a significant transformation. It underwent a substantial change which involved the government officially acknowledging the Samin beliefs. The research findings reveal symptoms of the Samin family law which underwent a transformation from customary law to local fiqh characterized by a mystical style. Efforts are being made to establish formal legal frameworks that accept the belief in God Almighty and incorporate legal practices. The legal negotiations led to the emergence of natural law plurality which in practice, is influenced by politics, social, and culture.
Dialectics Between Islam and Local Culture in Wetu Telu Lombok Muslims’ Merariq Tradition: An ‘Urf Perspective
Authors: Fawaizul Umam  , Al Humaidy Mohammad Ali , Amrulloh Moh. Asyiq
Published: June 2024

This article discusses dialectical teachings between Islam and local culture among Wetu Telu Muslims, a local community in Lombok, which is often accused of developing a prototype of Islamic teachings mixed with deviant, heterodox, and heretical traditions. The discussion focuses on one form of their traditions that reflects the dialectics, namely the merariq in wedding tradition. By applying a qualitative approach, this study specifically portrayed relevant views of Wetu Telu Muslims which are relatively different from that of orthodox Muslims in Lombok. Based on the results of participatory observation and unstructured in-depth interviews, the study findings reveal that the traditions of the Wetu Telu Muslims, especially in merariq, reflect a dialectical teaching between Islam and local culture so that it can be named as an Islamic tradition. It is also clear that Wetu Telu's teachings are extremely tolerant to the local culture and this is proven, among others, through their wedding tradition. From the ‘Urf perspective, merariq wedding tradition is legitimate for recognition as an Islamic culture or Islamic legal practice even though some aspects of the tradition differ from the general principles of Islamic orthodoxy in Indonesia.
Normatif Ve Görünürlük Boyutlarıyla Yenilenen Başarı Hedef Yönelim Ölçeğinin Kimya Dersi İçin Türkçe'ye Uyarlanması
Authors: Feyzioğlu Burak , Akyıldız Murat , Demirdağ Barış
Published: June 2024

Son yıllarda başarı hedef teorisinin performans boyutunun tanımlamasında sosyal karşılaştırmalarında dikkate alınmasıyla bu boyutun tanımlanmasına ve ölçülmesine ilişkin belirsizlikler ortadan kalkmıştır. Ancak ülkemizde kullanılan ölçme araçları hedef teorisindeki bu boyutları ayırt edemediği için bu konuda yapılan çalışmalar kuramsal sürecin gerisinde kalmıştır. Bu çalışmanın amacı Lüftenegger, Bardach, Bergsmann, Schober ve Spiel (2019) tarafından geliştirilen performans hedef yönelimini hem normatif hem de görünürlük açısından ele alan Başarı Hedef Yönelim Ölçeğini lise öğrencilerinin kimya dersindeki başarı hedef yönelimlerini ölçmek için uyarlamak ve psikometrik özelliklerini incelemektir. Çalışma grubu, farklı devlet okullarında kimya dersine devam eden 1487 lise öğrencisinden oluşmaktadır. Ölçeklerde yer alan alt ölçeklerin yapı geçerliliği doğrulayıcı faktör analizi ile test edilmiştir. Güvenilirlik çalışmaları için iç tutarlılık katsayısı Cronbach's alpha (α) değerlerinin yanı sıra McDonald's ω (omega) katsayıları hesaplanmıştır. Ayrıca ölçeklerde yer alan her bir madde için madde-toplam korelasyonları hesaplanmıştır. Doğrulayıcı faktör analizi sonuçları incelendiğinde, uyum indekslerinin Başarı Hedefi Ölçeği için uyum iyiliği kriterlerini karşıladığı kabul edilmiştir. Ölçekteki maddelerin faktör yükleri istatistiksel olarak anlamlıdır. Ölçeğin faktör yapısı cinsiyet, lise türü ve yaşanılan il değişkenlerine göre değişiklik göstermemektedir. Bu sonuçlar, her iki ölçeğin Türkçe formlarının bir kimya dersi için geçerlilik ve güvenilirlik açısından yeterli psikometrik özelliklere sahip olduğunu göstermiştir.
Pressupostos da luta antirracista na formação social brasileira
Authors: Santana Mauro Simões
Published: June 2024

Research indicators point to the social drama experienced by the black population in the country today. Facing racism is a commitment from the progressive camp to a fairer society. The work is based on the thesis that confronting racism in Brazil must be guided by an understanding of the specificities of the country's political economy in order for it to be effective. Based on a bibliographical review of authors who use historical materialism as a method of analyzing reality, the work intends to point out that racism is a social relationship engendered by the capitalist mode of production. According to these authors, we conclude that racism must be faced under an anti-capitalist orientation. We also conclude that the current tendency to delink the categories of race and class in the demands of black movements reflects a bourgeois counter-revolutionary ideological attack with the aim of relegating anti-racist action to a reformist horizon.
Grapevine leaf size influences canopy temperature
Authors: Migicovsky Zoë , Swift Joel F. , Helget Zachary , Klein Laura L. , Ly Anh , Maimaitiyiming Matthew , Woodhouse Karoline , Fennell Anne , Kwasniewski Misha , Miller Allison J. , Chitwood Daniel H. , Cousins Peter
Published: June 2024

Grapevine leaves have diverse shapes and sizes which are influenced by many factors including genetics, vine phytosanitary status, environment, leaf and vine age, and node position on the shoot. To determine the relationship between grapevine leaf shape or size and leaf canopy temperature, we examined five seedling populations grown in a vineyard in California, USA. The populations had one parent with compound leaves of the Vitis piasezkii type and a different second parent with non-compound leaves. In previous work, we had measured the shape and size of the leaves collected from these populations using 21 homologous landmarks. Here, we paired these morphological data with canopy temperature measurements made using a handheld infrared thermometer. After recording time of sampling and canopy temperature, we used a linear model between time of sampling and canopy temperature to estimate temperature residuals. Based on these residuals, we determined if the canopy temperature of each vine was cooler or warmer than expected, based on the time of sampling. We established a relationship between leaf size and canopy temperature: vines with larger leaves were cooler than expected. By contrast, leaf shape was not strongly correlated with variation in canopy temperature. Ultimately, these findings indicate that vines with larger leaves may contribute to the reduction of overall canopy temperature; however, further work is needed to determine whether this is due to variation in leaf size, differences in the openness of the canopy or other related traits.
Qual o estilo de aprendizagem predominante nos estudantes de secretariado executivo bilíngue da Universidade Federal da Paraíba, no Brasil?
Authors: Santiago Cibelle da Silva , Costa Alan Carlos Franco , Lima Thales Batista de
Published: June 2024

Objetiva-se identificar os estilos de aprendizagem dos estudantes concluintes do curso de Secretariado Executivo Bilíngue, da Universidade Federal da Paraíba, no Brasil. O referencial teórico amparou-se nos estilos de Aprendizagem de Kolb (1984). Os procedimentos metodológicos utilizados foram a pesquisa de campo com estudo de caso, sob abordagem quantitativa e análise dos dados com a estatística descritiva. Os sujeitos da pesquisa são os estudantes matriculados nos dois últimos períodos do citado curso de graduação, em que o universo é de 29 sujeitos e a amostra foi de 14 discentes. A partir da aplicação do Inventário de Kolb (1984) às turmas, identificou-se que o estilo de aprendizagem predominante nos estudantes foi o convergente. Nesse estilo, os indivíduos utilizam a Conceitualização Abstrata e a Experimentação Ativa no modo como aprendem algo, ou seja, combinam o pensar com o experimentar e, por isso, buscam a aplicação prática das ideias em situações específicas.
Exploring the Characteristics of Student Transformational Activities in Indonesia in Solving Cognitive Conflict-Based Problems
Authors: Rosimanidar  , Purwanto  , Hidayanto Erry , Sulandra I Made
Published: June 2024

This research aimed to describe the characteristics of the transformational activities of Indonesian students in resolving problems based on cognitive conflict. The research employed a phenomenological approach with five students as subjects. The research instruments included tests and interview guidelines, and the analysis was conducted using the constant comparative method. Change-based activities are a good way to solve cognitive conflict issues, including full rule-based unexpected results, full rule-based matching problem parts, incomplete rule-based unexpected results, and incomplete rule-based matching problem parts. Exploring these characteristics serves as a foundation for instructors to enhance the quality of instructional design. Practically, a profound understanding of these characteristics can provide a solid foundation for educators to enhance their instructional design quality. By exploring and comprehending how students address cognitive conflict, instructors can design more effective learning experiences that align with the student's needs.