bluuebunny/crossref_metadata_2025 huggingface dataset:
Deficiência Visual, Bioenergética e Grupo de Movimento: Um Relato de Experiência / Visual Impairment, Bioenergetics and Movement Group: An Experience Report
Authors: Lacerda Caio Márcio Freire , Mendes Maria Cristina Piauhy Silva
Published: January 2022

Resumo: A bioenergética é uma terapia corporal que possibilita o contato com o corpo e as emoções, portanto de grande importância para a população com deficiência visual, que praticando os exercícios de bioenergética passa a ter uma nova relação com o próprio corpo e com o ambiente externo. Este trabalho tem o objetivo de compartilhar a experiência de facilitar um grupo de movimento voltado para pessoas com deficiência visual vivenciando os exercícios de bioenergética. Foram percebidas mudanças significativas na forma de lidar com as próprias emoções e com o corpo. Melhora na qualidade do sono, atenção a respiração e menos estresse no dia a dia são alguns dos principais resultados ao final do grupo. Essa pesquisa ressalta os benefícios obtidos pelas pessoas que participaram do grupo, a disponibilidade e abertura dos participantes para experimentar as práticas sugeridas e ainda a viabilidade de fazer grupo de movimento com pessoas com deficiência visual.      Palavras-chave: deficiência visual, análise bioenergética, grupo de movimento, relato de experiência. Abstract: Bioenergetics is a body therapy that enables contact with the body and emotions, and is therefore of great importance for the visually impaired population, who by practicing bioenergetics exercises start to have a new relationship with their own body and with the world. The aim of this work is to share the experience of facilitating a movement group for people with visual impairments experiencing bioenergetics exercises. Significant changes were noticed in the way of dealing with their own emotions and with the body. Improved sleep quality, attention to breathing and less stress on a daily basis are some of the main results at the end of the group. This research highlights the benefits obtained by the people who participated in the group, the availability and openness of the participants to try the suggested practices and also the feasibility of forming movement group with people with visual impairments. Keywords: visual impairment, bioenergetics analysis, movement group, experience report.
Decolonising the curriculum: US Study Abroad: London Architecture and Urbanism – Albertopolis, South Kensington
Authors: Donnellan Caroline , Donnellan Caroline
Published: January 2022

This article focuses on ways of decolonising the curriculum of a one-semester London Architecture and Urbanism course taught differently across several US Study Abroad programmes in London. These introductory courses took place in the seminar room and out in the field. With the impact of the COVID-19 pandemic there has been a greater focus on teaching in open spaces. The courses are principally structured around the capital’s key public developments. Many of the sites have an older historical antecedence. They were largely built between the mid-eighteenth century and the opening decades of the twentieth century during the time of the Empire and the Industrial Revolution. While the Empire has gone, London continues to transmit ideas revolving around the cultural hegemony of a politically, economically and socially superior nation through its urban histories. These histories are sometimes explicit, but are more often hidden, as they become subsumed into London’s evolving cityscape. On this basis, introductory architectural courses that outline the city’s development, by default, recapitulate the values of British cultural imperialism. This article examines how London’s architectural history and imperial visions can be re-evaluated through the lens of a culturally responsive teaching and learning study abroad platform.
"Fiotim - O Museu em Movimento"
Authors: Mol Bárbara
Published: January 2022

Este artigo deriva da obra “Fiotim - O Museu em Movimento” (2015-), do artista Jorge Fonseca, que percorreu diversas cidades do Brasil com sua exposição caravana-circo-teatro-palco-museu. A pluralidade de nomes demonstra limiares pouco discerníveis entre os fenômenos artísticos e a polissemia com a qual os artistas trabalham hoje. Para compreender a amplitude artística, estética e social, vincula-se literatura, cinema, filosofia e sociologia em torno de uma proposta de arte imbricada com a arte contemporânea e com a arte popular, que entrelaça o social e cultural, o icônico e o onírico. Assim, olha-se para outros signos e imagens, por força da invenção artística, com o desejo de deslocar o pensamento teórico ao fluxo e ao movimento experimentados com a obra em questão.
UNDERSTANDING TEACHER PERFORMANCE THROUGH LEADERSHIP ROLE, WORK ENVIRONMENT, AND WORK MOTIVATION
Authors: Shanti Auliana  , Achmad Sani Supriyanto  , Sri Harini
Published: January 2022

Teachers have an essential role in determining the success of education. Teacher performance is of particular concern in the world of education. This study examines the influence of madrasah principal leadership, work environment, and work motivation on teacher performance. The research approach uses a quantitative approach with a correlational type. The population in this study were Madrasah Tsanawiyah Negeri teachers throughout Pidie Jaya Regency, Aceh Province. The sampling technique is purposive sampling. The data collection is a questionnaire measured by a Likert Scale. The validity test was calculated by comparing the r-table at a significant level of 0.05 with degrees of freedom (n-2). The reliability test was carried out using Cronbach Alpha. Data analysis used Partial Least Square to analyze the outer Model, Inner Model, and Bootstrapping. The results showed that the leadership of the madrasah principal had a significant positive effect on work motivation, the work environment has a significant positive impact on teacher work motivation, and the principal’s leadership also has a significant positive impact on teacher performance. The teacher’s work environment has a negative and insignificant effect on teacher performance, while work motivation has a positive and minor impact on teacher performance. Another finding is that there is no indirect effect between the principal’s leadership on teacher performance through work motivation. There is no indirect effect of the work environment on teacher performance through work motivation. Excellent leadership role, well-environment and high work motivation will optimize the teacher performance.
THE MANAGEMENT OF CURRICULUM IN INTEGRATED-ISLAMIC ELEMENTARY SCHOOL: FACILITATING QURAN LEARNING
Authors: Ahmad Fathur Rosyadi  , Subiyantoro
Published: January 2022

This research discusses the management of the Quran learning curriculum at Integrated-Islamic Elementary School of Luqman Al-Hakim Yogyakarta. This research is field research with a descriptive qualitative approach. The research data was taken from various scientific writings, school curriculum documents, field observation notes, and interviewees determined by non-probability sampling and purposive sampling. The data were tested by data triangulation and analyzed using the Miles & Huberman technique: (a) data reduction, (b) data presentation, (c) conclusion and verification. The results: The Quran learning curriculum is a set of educational program plans, target achievements, and learning strategies that are carried out so that students read the Quran Tartil and have three juz of memorization. The curriculum management process includes planning, organizing, implementing, and evaluating.
INNOVATING STUDENT ADMISSION USING NEUROSCIENCE PERSPECTIVE: LEARNING FROM MUHAMMADIYAH VOCATIONAL SCHOOLS
Authors: Mohammad Jailani  , Perawironegoro Djamaluddin , Widodo Hendro
Published: January 2022

The pandemic  COVID-19 has opened new horizons in all parts of the world, including in education. Educational institutions must make breakthroughs related to the number of student admissions, which has decreased significantly, especially at Vocational School of Muhammadiyah 3 Yogyakarta. The purpose of this study was to find a promotion model for student admissions from a neuroscience perspective at Vocational School of Muhammadiyah 3 Yogyakarta. This study uses a qualitative method. The subjects of this study were the principal, the vice principal for student affairs, the vice principal for public relations, the head of the admission committee, and the prospective students. Researchers used observation, interviews, and documentation as data collection techniques. The data were analyzed using the Miles and Huberman model, namely data reduction, display data, and conclusion drawing/verification data. This study indicates that neuroscience as a brain approach (cortex prefrontal) can attract the sympathy of prospective new students to study at Vocational School of Muhammadiyah 3 Yogyakarta. It is a solution to meet the target group for majors at school. This research has implications for school management and Islamic education management in student admission department.
Efficiency of Mathematical Modeling of Competitiveness of a Business Organization in the Coverage of Regional Integration
Authors: Zhanna S. Chupina , Bondarenko Aleksey V. , Evgenia E. Kuzmina , Gavrilovich Starovoitov Vladimir
Published: January 2022

The following research problem was solved in the work: what model should be used to quantify the calculation of the competitiveness of an organization's business efficiency in the scope of regional integration? In accordance with the set research task, its goal was determined. The purpose of this work was to assess the competitiveness of business in the scope of regional integration. The research sample consisted of large enterprises operating on the territory of the integration association - the EAEU. Competitiveness is now a commonly used term that can be analyzed at different levels - at the enterprise level or at the national level. Despite the fact that the purpose of this article is the competitiveness of production systems, it is appropriate to pay attention to the competitiveness of a business organization in the context of regional integration in which these systems operate. Macroeconomic competitiveness must always take into account the microeconomic context. Even the best public policy is ineffective if it is not implemented in the context of the business sector.
Organizing the Home Front: The American Women’s Voluntary Services in New Jersey during World War II
Authors: Chappine Patricia
Published: January 2022

During World War II (WWII), the American Women’s Voluntary Services (AWVS) became the largest service organization in the U.S. At the onset of American entry into WWII, the AWVS already included 18,000 volunteers. Within two years of its creation, the group expanded to 350 chapters nationwide, with the height of its wartime membership reaching roughly 325,000. Both on a national and local level, the AWVS proved instrumental to the success of home-front mobilization during WWII. With numerous community chapters, significant wartime initiatives, and proximity to the national AWVS in New York City, the New Jersey groups serve as a starting point for a more nuanced reflection on the AWVS during WWII. Along with considerations of gendered citizenship and volunteerism, the narrative of the AWVS presents women who both adhered to accepted forms of volunteerism and pushed social boundaries. The activities of the AWVS occupied a space somewhere in between nurturing and militaristic, blurring gendered lines of acceptable wartime participation and occupying a unique role not easily categorized. These women reimagined local activism and cooperation as encompassing more than their socially accepted supporting roles and expanded into areas of civilian defense, disaster response, emergency preparedness, and more.
Lost and Found: Rediscovering a Seventeenth Century Map of New Jersey
Authors: Aumack Douglas T.
Published: January 2022

This narrative details the first complete map of New Jersey; one that identified the locations of settlements of indigenous people. Created by Hessel Gerritsz, a Dutch master cartographer, this relatively unknown 1616 map of New Jersey does not appear in the four major publications that exhibit New Jersey maps, published between 1973 and 2014.
Inflation Targeting and Economic Performance: Application of the New Keynesian Small Open Economy DSGE
Authors: Habiby Salwa
Published: January 2022

Bank Al-Maghrib aim to adopt the inflation targeting regime to keep pace with changes in the monetary policy environment. The challenge for the central bank is to meet the prerequisites of inflation targeting to ensure the anchoring of expectations, and thus achieve the inflation target and real stability.

The objective of this paper is to propose an optimal model for Morocco's successful transition to inflation targeting.

To do so, we build a New Keynesian Small Open Economy DSGE model, characterized by financial frictions, imperfect exchange rate pass-through, unemployment, fiscal rule and new shocks. The results of our simulations lead us to assert that it would be wise to choose the most complete model, since it provides credibility, stability and growth.

Keywords: anchoring expectations, inflation targeting, economic growth, DSGE, financial frictions.
Inferring case paradigms in Koalib with computational classifiers
Authors: Quint Nicolas , Allassonnière-Tang Marc
Published: January 2022

The object case inflection in Koalib (Niger-Congo) represents complex patterns that involve phoneme position, syllable structure, and tonal pattern. Few attempts have been made with qualitative and quantitative approaches to identify the rules of the object case paradigms in Koalib. In the current study, information on phonemes, tones, and syllables are automatically extracted from a Koalib sample of 2,677 lexemes. The data is then fed to decision-tree-based classifiers to predict the object case paradigms and extract the interactive patterns between the variables. The results improve the predicting accuracy of existing studies and identify the case paradigms predicted by linguistic hypotheses. New case paradigms are also found by the computational classifiers and explained from a linguistic perspective. Our work demonstrates that the combination of linguistic theoretical knowledge with machine learning techniques can become one of the methodological approaches for linguistic analyses.
Transport properties of the new vibratory conveyor at operations in the resonance zone
Authors: Surówka Witold , Czubak Piotr
Published: January 2022

The new vibratory conveyor intended for the precise material dosage was investigated in the hereby study. The transport possibilities in the circum-resonance zone were tested analytically as well as by simulation. The optimal working point of the system, allowing to lower the vibration amplitude of the eliminator on its own suspension, was found. Transport velocities in dependence on the excitation frequency were determined by simulation. The results were verified on the specially designed industrial conveyor whose parameters were determined using analytical and simulation investigations, built according to the patent application.
The crystal structure of 1-methyl-1H-pyrazol-2-ium nitrate, C4H7O3N3
Authors: Cong Chen , Yun Xiao , Chong Li , LiZhen Chen , Jianlong Wang
Published: January 2022

C4H7O3N3, orthorhombic, Pnma (no. 62), a = 14.2289(10) Å, b = 6.1881(4) Å, c = 7.5592(5) Å, V = 665.59(8) Å3, Z = 4, R

gt
(F) = 0.0427, wR

ref
(F
2) = 0.1098, T = 150 K.
Refining gentleness – a key to bulky CTMP
Authors: Berg Jan-Erik , Persson Erik , Hellstadius Börje , Edlund Henrik , Granfeldt Thomas , Lundfors Mikael , Engstrand Per
Published: January 2022

Chemithermomechanical pulp (CTMP) is often used in middle layers of multiply paperboards due to its high bulk at specified strength. Such a CTMP should consist of well-separated undamaged fibres with sufficient bonding capacity. The basic objective of this work is to examine the effect of refining on bulk, taking into account conditions such as temperature, sulphonation, refining gap and refiner size. First stage CTMP made from Norway spruce (Picea abies) were produced in pilot and mill scale trials. Two new parameters,Equivalent temperature related to softnessandRefining gentlenessare introduced that take into account refining conditions as actual temperature, softening temperature, bound sulphonate content, refining gap and refiner diameter. The results show that bulk increases linearly with refining gentleness.
Analysis of aeromagnetic filtering techniques in locating the primary target in sedimentary terrain: A review
Authors: Aina Oni Olubukola , Aizebeokhai Ahzegbobor P. , Oritsemamididasan Boyo Henry
Published: January 2022

This article analyzes some aeromagnetic filtering techniques for mitigating deceptive geophysical conceptions that may result in a distorted range of geological information from aeromagnetic data. The implication of using the aeromagnetic method, data processing, and enhancement to distinguish sediment-produced anomalies was considered. Two methods to locate buried faults in aeromagnetic data were compared: Edge and fault detection were considered using the magnetic contrast and horizontal gradient methods, whereas rapid depth estimation was considered using the Euler deconvolution method and Signum method. The general challenge to find the magnetic anomaly depth and delineate edges relies on geophysical filtering techniques discussed in order to maintain its geological relevance. The magnetic-contrast layer model signatures help clarify the existence of intra-sedimentary faults. The horizontal gradient approach relative to other derivative methods has better noise stability and fast adaptation to grids without modifying parameters. However, the Signum transform (ST) approach offers a more special solution in depth estimation than the Euler’s deconvolution approach whose solution relies on the required choice of default shape parameters and windows. The Euler deconvolution procedure may not be able to detect structures found by the ST approach and vice versa. As a result, these techniques may be used in conjunction with one another during analysis, as complementary interpretation tools. This review will however aid in the analysis of information used as a criterion for determining faults using various analytical techniques like ST or Euler deconvolution.
Fully Legendre spectral collocation technique for stochastic heat equations
Authors: Abdelkawy Mohamed A. , Ahmad Hijaz , Jeelani Mdi Begum , Alnahdi Abeer S.
Published: January 2022

For the stochastic heat equation (SHE), a very accurate spectral method is considered. To solve the SHE, we suggest using a shifted Legendre Gauss–Lobatto collocation approach in combination with a shifted Legendre Gauss–Radau collocation technique. A comprehensive theoretical formulation is offered, together with numerical examples, to demonstrate the technique’s performance and competency. The scheme’s superiority in tackling the SHE is demonstrated.
Computational examination of Jeffrey nanofluid through a stretchable surface employing Tiwari and Das model
Authors: Shahzad Faisal , Jamshed Wasim , Koulali Aimad , Aissa Abederrahmane , Safdar Rabia , Akgül Esra Karatas , Ibrahim Rabha W. , Nisar Kottakkaran Sooppy , Badruddin Irfan Anjum , Kamangar Sarfaraz , Saleel C. Ahamed
Published: January 2022

In this research, we analyze the magnetohydrodynamics heat act of a viscous incompressible Jeffrey nanoliquid, which passed in the neighborhood of a linearly extending foil. As a process, we employ alumina

(

Al

2

O

3

)

\left({{\rm{Al}}}_{2}{{\rm{O}}}_{3})

as nanoparticles, assuming that the base fluid is ethylene glycol. In this involvement, we consider the heating by Joule effect and viscous dissipation. We select the passable transformations, motion, and temperature formulas converting into non-linear differential equation arrangement. We solved the system by using a Keller-box method. Then, we provide a graphical description of outcomes according to the selected control parameters. Higher values of dissipation parameter cause a surge in temperature field as well as strengthen width of the heat boundary layer. The velocity, drag coefficient, and heat transfer (HT) rate for the base fluid are comparatively greater than that of the

Al

2

O

3

{{\rm{Al}}}_{2}{{\rm{O}}}_{3}

–ethylene glycol nanofluid, although the temperature is embellished by the inclusion of nanoparticles. Moreover, we report depreciation in surface drag as well as HT by the virtue of amplification in the Deborah number. The proclaimed outcomes are advantageous to boost the incandescent light bulb’s, cooling and heating processes, filament emitting light, energy generation, multiple heating devices, etc.
Emotional musical prosody for the enhancement of trust: Audio design for robotic arm communication
Authors: Savery Richard , Zahray Lisa , Weinberg Gil
Published: January 2022

As robotic arms become prevalent in industry, it is crucial to improve levels of trust from human collaborators. Low levels of trust in human–robot interaction can reduce overall performance and prevent full robot utilization. We investigated the potential benefits of using emotional musical prosody (EMP) to allow the robot to respond emotionally to the user’s actions. We define EMP as musical phrases inspired by speech-based prosody used to display emotion. We tested participants’ responses to interacting with a virtual robot arm and a virtual humanoid that acted as a decision agent, helping participants select the next number in a sequence. We compared results from three versions of the application in a between-group experiment, where the robot presented different emotional reactions to the user’s input depending on whether the user agreed with the robot and whether the user’s choice was correct. One version used EMP audio phrases selected from our dataset of singer improvisations, the second version used audio consisting of a single pitch randomly assigned to each emotion, and the final version used no audio, only gestures. In each version, the robot reacted with emotional gestures. Participants completed a trust survey following the interaction, and we found that the reported trust ratings of the EMP group were significantly higher than both the single-pitch and no audio groups for the robotic arm. We found that our audio system made no significant difference in any metric when used on a humanoid robot implying audio needs to be separately designed for each platform.
Flow-measurements in the wake of an oscillating sessile droplet using laser-Doppler velocity profile sensor
Authors: Burgmann Sebastian , Krämer Veronika , Dues Michael , Steinbock Jonas , Büttner Lars , Czarske Juergen , Janoske Uwe
Published: January 2022

Although relevant in many technical applications, the removal of sessile droplets on surfaces by an (air-) flow is still hard to predict. The flow around the droplet has not been investigated in detail so far but knowledge on the flow structure is essential for the assessment of appropriate drag force correlation. Small droplets (in the range of 5–40 µl) on PMMA substrate in an air flow are investigated. Due to the small size of the droplet the laser-Doppler velocity profile sensor with frequency shift is applied to measure the flow in the wake of the oscillating, still adhering droplet. Thanks to the high spatial and temporal resolution of Laser-Doppler velocity profile sensor and its capability to measure bidirectional flows, the flow behind the droplet can be precisely analyzed. Additional hot-film measurements are used to investigate the temporal behavior of the flow. Complementary, numerical simulation is performed applying a modified VOF (Volume-of-Fluid) method. The combination of the experimental and numerical data gives new insight in the wake flow structure of sessile droplets: With increasing Reynolds number, a backflow can be detected in the wake of the droplet. A separated shear layer stemming from the upper side of the droplet leads to a vortex shedding with formation of a recirculation region in the temporal mean. In contrast to rigid hemispheres, the movement of the air-liquid interface of the droplet leads to an internal flow which is driven by the outer flow structure and vice versa. This is a hint that drag coefficients of sessile droplets cannot be simply derived by analyzing flows of rigid hemispherical structures. Additionally, droplet contour and wake flow exhibit the same characteristic oscillation frequency. The corresponding Strouhal number is almost constant at 0.03 compared to the Strouhal number of a rigid hemisphere of 0.28. Therefore, it can be assumed that an aeroelastic self-excitation effect may be present that eventually leads to droplet movement.
Improved Interpretation of British Pendulum Test Measurements for Evaluation of Floor Slip Resistance
Authors: Cui X. , Chu L. , Guo W. , Fwa T. F.
Published: January 2022

The widely used British pendulum test (BPT) for pedestrian slip resistance evaluation obtains its measurements from a numerical reading scale and reports the test result as either a British pendulum number (BPN) or pendulum test value (PTV). There exist two issues that, if resolved, could significantly enhance the practical application value of BPT: (1) Different units of the BPT device could produce BPN readings with differences higher than 20 %, mainly due to their different slider force–deflection characteristics; (2) the relationship between BPN and coefficient of friction (COF) of the floor is nonlinear for a given BPT device, and it varies from one BPT device to another because of issue (1). This study demonstrates that, by means of a finite element BPT simulation model developed based on the theory of mechanics, the COF of a floor can be determined from the measured BPN of a BPT. It is shown that the commonly adopted practice of applying a single regression equation relating BPN to COF does not correctly represent the relationship between BPN and COF. This is because, in practice, different BPT devices would most likely have different slider force–deflection characteristics. The proposed simulation model approach would overcome this problem effectively by converting BPN measurements into COF, based on the respective slider force–deflection characteristics of the BPT devices concerned. In so doing, both issues (1) and (2) could be effectively resolved. Validation experiments were performed to confirm the validity of the simulation model and the COF calculated.
Which one of the three latest large earthquakes in Zagreb was the strongest – the 1905, 1906 or the 2020 one?
Authors: Herak Marijan , Herak Davorka , Živčić Mladen
Published: January 2022

Following the damaging earthquake of 22 March 2020 (ML = 5.5, Mw = 5.3, Imax = VII EMS) in Zagreb, a question was raised whether this was the largest event after the Great Zagreb earthquake of 1880 (Imax = VIII MSK). The countercandidates are the events of 17 December 1905 and 2 January 1906, for which relevant earthquake catalogues mostly report larger or comparable magnitudes as for the earthquake of 2020, with their maximum intensities mostly within a narrow margin between VII and VII–VIII in various intensity scales. In order to resolve the question, we have (re)analysed all available macroseismic data for the two historical events, collected readings from station bulletins, and analysed available historical seismograms. Macroseismic proxy for the local magnitude (MmR) was estimated on the basis of modelled radii of isoseismals V EMS and VI EMS using the regressions derived for a set of 12 earthquakes in NW Croatia and the neighbouring areas. Macroseismic magnitude was found to be the largest for the 1906 event (MmR = 5.3), followed by MmR = 5.1 for the 2020 quake. Considering the magnitudes computed after Wiechert seismograms from the Göttingen (GTT) station, and from the amplitude/period readings reported from the German stations JEN and HOH for the earthquake of 1906, as well as the magnitudes calculated from broad-band records of the GTTG station and the stations of the Croatian network for the event of 2020, a unified local magnitude of ML = 5.3 is found for both events. The magnitudes of the 1905 earthquake were consistently the lowest of the three. Taking the uncertainties into account, the events of 1906 and 2020 should be considered approximately equal in size. However, the strongest shaking in the centre of Zagreb was caused by the 2020 event. It occurred on the reverse North Medvednica boundary fault, while the macroseismic epicentres of earthquakes of 1905 and 1906 lie practically on the trace of the nearby strike-slip Kašina fault. That Kašina fault could have been the source of the 1906 earthquake is also hinted at by the elongated region of the strongest shaking along its strike.
Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia
Authors: McGlacken-Byrne Sinéad M , Mohammad Jasmina Kallefullah , Conlon Niamh , Gubaeva Diliara , Siersbæk Julie , Schou Anders Jørgen , Demirbilek Huseyin , Dastamani Antonia , Houghton Jayne A L , Brusgaard Klaus , Melikyan Maria , Christesen Henrik , Flanagan Sarah E , Murphy Nuala P , Shah Pratik
Published: January 2022

Objective

The phenotype mediated by HNF4A/HNF1A mutations is variable and includes diazoxide-responsive hyperinsulinaemic hypoglycaemia (HH) and maturity-onset diabetes of the young (MODY).

Design

We characterised an international multicentre paediatric cohort of patients with HNF4Aor HNF1Amutations presenting with HH over a 25-year period (1995–2020).

Methods

Clinical and genetic analysis data from five centres were obtained. Diazoxide responsiveness was defined as the ability to maintain normoglycaemia without intravenous glucose. Macrosomia was defined as a birth weight ≥90th centile. SPSS v.27.1 was used for data analysis.

Results

A total of 34 patients (70.6% female, n  = 24) with a mean age of 7.1 years (s.d. 6.4) were included. A total of 21 different heterozygous HNF4Amutations were identified in 29 patients (four novels). Four different previously described heterozygous HNF1A mutations were detected in five patients. Most (97.1%, n  = 33) developed hypoglycaemia by day 2 of life. The mean birth weight was 3.8 kg (s.d. 0.8), with most infants macrosomic (n = 21, 61.8%). Diazoxide was commenced in 28 patients (82.3%); all responded. HH resolved in 20 patients (58.8%) following a median of 0.9 years (interquartile range (IQR): 0.2–6.8). Nine patients (n = 9, 26.5%) had developmental delay. Two patients developed Fanconi syndrome (p.Arg63Trp, HNF4A) and four had other renal or hepatic findings. Five (14.7%) developed MODY at a median of 11.0 years (IQR: 9.0–13.9). Of patients with inherited mutations (n = 25, 73.5%), a family history of diabetes was present in 22 (88.0%).

Conclusions

We build on the knowledge of the natural history and pancreatic and extra-pancreatic phenotypes of HNF4A/HNF1Amutations and illustrate the heterogeneity of this condition.
The effect of gestational age on mitochondrial properties of the mouse placenta
Authors: Bartho Lucy A , Fisher Joshua J , Walton Sarah L , Perkins Anthony V , Cuffe James S M
Published: January 2022

Mitochondria are organelles within the cell that generate energy, which is essential to the developing placenta. As the placenta approaches term, organelles such as mitochondria and the endoplasmic reticulum adapt to cellular stressors (e.g. oxidative stress and fluctuations in oxygen concentration) which are likely to result in the progressive decline of tissue function, known as placental ageing. This ageing phenotype may induce cellular senescence, a process whereby the cell is no longer proliferating, yet remains metabolically active. Mitochondria, endoplasmic reticulum and senescent processes are still poorly understood in the developing placenta. Therefore, a rodent ontogeny model was used to measure genes and proteins involved in mitochondrial biogenesis, antioxidant function, electron transport chain, mitophagy, dynamics and unfolded protein response in the placenta. CD-1 mouse placental samples were collected at embryonic day (E)12.5, E14.5, E16.5 and E18.5 of pregnancy for gene and protein analysis via qPCR, protein assays and Western blotting. Mitochondrial content, SDHB (complex II) and MFN2 (mitochondrial fusion) proteins were all increased throughout pregnancy, while citrate synthase activity/mitochondrial content, Tfam, Sirt3, Mfn1, TOMM20 (mitochondrial biogenesis and dynamics); Tp53(senescence); Eif2ak3, Eif4g1(endoplasmic reticulum stress);NDUFB8, UQCRC2, ATP5A (electron transport chain sub-complexes) were decreased at E18.5, compared to E12.5. Overall, mitochondria undergo changes in response to gestational progression and pathways associated with cellular ageing to facilitate adaptions in a healthy pregnancy. This data holds great promise that mitochondrial markers across pregnancy may help to establish when a placenta is ageing inappropriately.

Lay summary

Human pregnancy lasts approximately 266 days. If a baby is born early, organs may be poorly formed but if pregnancy continues past this time, stillbirth risk is increased. Gestational duration is regulated by the placenta. As the placenta approaches the end of pregnancy, it displays properties similar to tissues from aged individuals. However, it is unknown how this placental ageing contributes to pregnancy duration. This study characterised normal placental ageing by measuring properties of mitochondria in healthy placentas collected at four different gestational ages ranging from 7 days before birth to 1 day before birth of the 19-day mouse pregnancy. We found that mitochondrial number increased per cell but that a marker of mitochondrial function was reduced. Proteins that control mitochondrial number, morphology and function also changed over time. This work lays the platform to understand how placental ageing contributes to adverse pregnancy outcomes related to altered pregnancy duration.
Supplementary studies on Myxobolus talievi Dogiel, 1957 (Cnidaria, Myxozoa) from the skeletal muscle of the cottoid fish Cyphocottus eurystomus in Lake Baikal: Morphological, histological and molecular characterisations
Authors: Batueva Marina Dashi-Dorjievna , Burdukovskaya Tatyana Gennadyevna
Published: January 2022

Myxobolus talievi Dogiel, 1957 was originally described from the eyes, skeletal muscles and body cavity of endemic cottoid fish from Lake Baikal. In the present study, we supply new information on the myxospore morphology and histopathology of M. talievi; furthermore, we complete the original species description by Dogiel and Bogolepova (1957) with 18S ribosomal DNA (rDNA) sequence data. Histopathological analysis showed that the plasmodium was encapsulated by a thin layer of connective tissue and located in the intermuscular connective tissue among muscle cells. No inflammation was observed. Phylogenetic analysis revealed that M. talievi clustered with Myxobolus sp. 2 (NCBI Acc. No. U13830), an unidentified Myxobolus species from cottoid fish studied by Smothers et al. (1994), and located in the sister clade of Myxobolus spp. developing spores in the nerves of salmonids.
Economic Adaptation and Individual Livelihood Strategies in a Swabian Village in Satu Mare County
Authors: Borbély Sándor
Published: January 2022

This paper summarizes the first partial results of economic anthropological research conducted in the Swabian settlement of Mezőfény (Romanian: Foieni) in Satu Mare County (Romania). The aim of the research is to describe the livelihood and income-earning strategies among agricultural production groups in local society and to interpret different forms of economic adaptation (individual, household and community level) in the settlement within the context of the post-socialist transformation from a planned to a capitalist market economy.
PILES BEARING CAPACITY IN PERMAFROST SOILS UNDER CLIMATE CHANGE
Authors: Nikiforova N. S , Konnov A. V
Published: January 2022

The one of the main natural systems in the Russian Federation that are exposed to global warming is the permafrost zone. The temperature of permafrost soils changes, the seasonal thaw zone increases, the process of permafrost degradation is started, influencing the strength characteristics of the soils. The study was aimed to assess the climate change in terms of the impact on the bearing capacity of the soil base under buildings and structures built in the 1960s and 1980s on the Principle I (maintaining the permafrost state of the soil). On the basis of published archival and forecast data on the increase rate in the active layer thickness and the rising temperature trends of permafrost soils for seven geographical regions of Russia (North of the European part, North of Western Siberia, Middle Siberia, Yakutia, Southern Siberia, Baikal region and North-East of Russia) a reduction in the bearing capacity of the standard reinforced concrete pile (35´35 cm section, 10 m long) was determined. The study revealed that for now in most regions the reduction in the bearing capacity of the pile is on average level (10-20 %). However a high (>30 %) decrease is expected by 2050. The temperature distribution in the soil mass was modelled in the Frost 3D program for the conditions of Norilsk, considering the thermal influence of the building. Numerical modelling was performed for a period of time until the middle of the XXI century. In the base of a building the resulting significant settlement of the thawing soil under its own weight can lead to the occurrence of negative friction forces. This effect must be taken into account when calculating pile foundations.
THE LONG SHELL PILE BEARING CAPACITY CALCULATION
Authors: Matveev S. A , Martynov E. A , Litvinov N. N , Kryzhanovsky G. A
Published: January 2022

A comparative assessment of the long steel shell-pile bearing capacity is carried out in conditions of deep bedding of dense soils on the example of the Crimean bridge. The soil column is represented by six layers of soil only the last sixth layer of which located at a depth of 62 m has a high bearing capacity. Three design schemes are considered, taking into account soil resistance along the outer side surface and under the lower end of the pile, along the outer and inner side surfaces of the pile, as well as along the outer side surface and under the lower end of the pile, taking into account the soil core and self-locking effect. The results of calculating the bearing capacity of the steel pile-shell for each of the design schemes are presented in tabular and graphical form. Conclusions are drawn about the nature of the change in the soil resistance forces with the depth of the pile immersion both along its outer and inner lateral surfaces as well as under its lower end. The depth at which the soil core formation begins as well as the depths within which the soil is compacted and self-locking inside the pile cavity has been established. In this case the pile begins to work as a pile with a closed lower end and a further increase in its bearing capacity occurs due to the frictional forces of the soil along the outer lateral surface. A comparison is made of the bearing capacity values calculated for each of the three design schemes with the partial value of the ultimate resistance according to immersion data with actual (measured) residual failures based on the results of field tests with dynamic load.
DETERMINATION OF ADDITIONAL LOAD ON THE BRIDGE FOUNDATION PILE when the karst deformation development
Authors: Gotman N. Z , Evdokimov A. G
Published: January 2022

When karst deformations are formed at the base of bridge supports, additional loads are transferred to the piles, and the bearing capacity of the base decreases. The article proposes methods for determining additional loads on the piles and the bearing capacity of piles, depending on the type of karst deformations. A method for numerical variation calculations based on the analysis of the change of shear stresses on the lateral surface of the piles at different stages of loading with the growth of a cavity in karst soils. The correct design model and criteria for evaluation the stability of the arch over the cavity were selected. A series of numerical calculations were performed. Analytical solutions to determine the additional load on the pile depending on the distance from the bottom of the pile to the roof of karst soils and the predicted diameter of the cavity in karst soils were obtained.
THE LOW TEMPERATURE INFLUENCE ON THE DEEP EXCAVATION SUPPORTING SYSTEM
Authors: Boyarintsev A. V , Zavodchikova M. B , Zuev I. N , Zhurko A. V , Kamaev I. S
Published: January 2022

The practical experience to dig an excavation shows that this process is extended in time and can last for several months engulfing different seasons. An additional accounting of processes occurring in excavation shoring and surrounding soil body during wintertime, when the air temperature drops below zero, is important in such circumstances. This paper describes the results of a field survey of shoring of a deep excavation, soil body and buildings of a surrounding development as the air temperature was changing during the 2020-2021 winter. The survey was performed by monitoring the horizontal and vertical positions of structures using inclinometers and tacheometers. The heaving properties of the clay soil positioned at the excavation digging level were determined in laboratory conditions. The soil frost depth was determined by a numerical simulation of temperature distributions in the "atmosphere-excavation-soil body" system. All this helped understand the nature of the processes observed. The observation results showed that, as the temperature was decreasing, the excavation shoring structures moved into the excavation to a distance of up to 8 mm, and the surrounding development buildings shrank by up to 5 mm. The laboratory study results showed in this context that soils bordering on the shoring structures and foundations of surrounding buildings were not heaving. Thereupon, the strains, which were registered in this actual situation, can not be explained by the frost-heaving phenomenon. The observed strain can be explained by shrinkage of the sprung structure material resulting from a decreasing mean daily air temperature. This effect was confirmed by test results and several surveys presented in the paper. Based on the study conclusions practical guidelines were formulated for excavation digging with consideration to seasonal air temperature fluctuations causing shrinkage and expansion of sprung structures in the shoring structures of excavation of any depth.
DIRECTIONS OF TRANSFORMATION OF ENERGY SUPPLY SYSTEMS TAKING INTO ACCOUNT THE PROSPECTIVE DEVELOPMENT OF TERRITORIES
Authors: Beloglazova T. N , Romanova T. N
Published: January 2022

Modern cities have a multi-level structure of technological systems that functionally and organizationally meet the needs of consumers. The development of urban areas requires an integrated approach. Heat and gas supply systems are the main element of energy systems. In accordance with the economic, social and technological conditions, heat and gas supply systems undergo organizational and structural transformations. The purpose of the study is to develop promising schemes of heat and gas supply systems for territories based on mutual influence. Methods. Based on the analysis of the functional and planning zoning of urban areas, the calculation method provides options for the development of heat and gas supply schemes. The implementation of modern standards of heat supply is possible due to multivariate approaches. The reliability of the research results is ensured by the use of proven calculation methods. Residential neighborhoods with a load on heat supply and household consumption are considered as the main consumers. Small industrial and municipal facilities are taken into account when planning the use of energy resources in the considered territory. Industrial consumption, as a rule, has an independent system of heat and gas supply. The method for determining loads is based on specific normative indicators. When developing the gas distribution scheme for urban areas, the possibility of spreading the load on the heat supply is taken into account. Results. On the one hand, the developed variants of heat and gas supply schemes were considered as alternative ones. Both the scheme of the main heat supply networks and the gas distribution scheme will be able to perform functional tasks to provide subscribers with resources for the considered design area independently. On the other hand, at different stages of system development, alternative options can complement each other, according to the periods of phased development, taking into account the criteria of reliability and cost-effectiveness. Conclusions. The variants of heat and gas supply systems allowed us to identify the main linear parameters for different building densities. The general material criterion for heat and gas supply systems is the material characteristic. The development of heat and gas supply schemes, taking into account the mutual influence, ensures a stable and economical development of the territory.
Endomembrane remodeling and dynamics in Salmonella infection
Authors: Fang Ziyan , Méresse Stéphane
Published: January 2022

Salmonellae are bacteria that cause moderate to severe infections in humans, depending on the strain and the immune status of the infected host. These pathogens have the particularity of residing in the cells of the infected host. They are usually found in a vacuolar compartment that the bacteria shape with the help of effector proteins. Following invasion of a eukaryotic cell, the bacterial vacuole undergoes maturation characterized by changes in localization, composition and morphology. In particular, membrane tubules stretching over the microtubule cytoskeleton are formed from the bacterial vacuole. Although these tubules do not occur in all infected cells, they are functionally important and promote intracellular replication. This review focuses on the role and significance of membrane compartment remodeling observed in infected cells and the bacterial and host cell pathways involved.
Análise de um circuito de corrente constante através dos conceitos da eletrostática
Authors: Fonseca Anderson , Penello Germano Maioli
Published: January 2022

A eletrostática e os circuitos de corrente constante são tradicionalmente discutidos sem que sua conexão seja claramente evidenciada. A estrutura conceitual e os métodos operacionais analíticos desenvolvidos no estudo da eletrostática não são utilizados na análise dos circuitos. Para promover a aproximação entre esses dois campos de estudo, será examinado um circuito composto por uma bateria e fios condutores onde a distribuição superficial de carga assume o protagonismo da relação causal quando se investiga o surgimento da corrente elétrica. Dessa forma, o conhecimento sobre a interação das cargas elétricas pode ser empregado para compreender os processos físicos que ocorrem nos componentes do circuito à medida que as conexões entre eles são estabelecidas. Ao se examinar o circuito dessa maneira, amplia-se o espectro de problemas que podem ser discutidos dentro do mesmo conteúdo.