bluuebunny/crossref_metadata_2025 huggingface dataset:
A TEORIA QUEER E O DIREITO DE RETIFICAÇÃO DE REGISTRO CIVIL DE PESSOA NÃO BINÁRIA
Authors: Hegele Bolson Simone
Published: July 2024

O tema do presente artigo é a teoria Queer e o direito de retificação de registro civil de pessoa não binária. Não obstante as recentes modificações quanto ao nome, em razão da Lei 14.382/2022, a Lei de Registros Públicos, em seu artigo 54, 2º continua a prever a necessidade de informação sobre o sexo/gênero da pessoa em uma ótica binária – masculino ou feminino. Para além dessa designação, a teoria Queer alberga um novo olhar sobre conceitos milenarmente construídos em torno de um binarismo de gênero e sexo. Pretende-se discorrer sobre a teoria Queer e de como ela desconstrói a ótica binária, reconhecendo-se que, hoje, as identidades pessoais abarcam uma realidade distinta do que a norma ainda prevê. Essa nova realidade – a dos não binários – já é tema de decisões nos tribunais brasileiros, julgando-se pela possibilidade de retificação do assento registral em consonância com o princípio da dignidade da pessoa humana, autodeterminação e livre exercício da personalidade. Objetiva-se analisar decisões de tribunais que acolheram (ou não) a pretensão retificadora de não-binários, defendendo-se o reconhecimento da retificação no registro civil e propugnando-se pelo acolhimento de tal modificação inclusive via extrajudicial, em cartório. Utilizou-se o método hipotético-dedutivo, com técnica de pesquisa e análise documental, embasando-se o artigo nos (novos) postulados de uma teoria que já ultrapassou os muros da Sociologia e Filosofia e oferece aporte jurídico aos indivíduos não binários.
35 YEARS OF BRAZILIAN CONSTITUTION: CONSTITUTIONAL AMENDMENT No. 115/2022 AND THE IMPORTANCE OF PROTECTING PERSONAL DATA AS A FUNDAMENTAL RIGHT
Authors: Gonçalves da Silva Lucas , Felix Nascimento Reginaldo , Rocha da Silva Lívia Nayara
Published: July 2024

This work should be considered a panoramic work, which establishes the process of evolution of the Fundamental Right to the Protection of Personal Data in Brazil, taking as a starting point the Constitution of the Federative Republic of Brazil of 1988, until its formalization as a Fundamental Right Autonomous and Express through Constitutional Amendment No. 115/2022. Furthermore, the work addresses the social and economic aspects that demonstrate the context and importance of having the protection of personal data as a Fundamental Right, which binds all agents in society. Finally, the work addresses the infraconstitutional peculiarities of personal data protection in Brazil, to demonstrate how this Fundamental Right behaves outside the constitutional text. The method used was hypothetical-deductive, using bibliographic and documentary resources. Finally, the Fundamental Right to the Protection of Personal Data functions as a very important right to protect subjects in private relationships, so that it is possible to affirm, in the 35 years since the Constitution of the Federative Republic of Brazil of 1988, that the constitutional text remains compromised with the preservation of the axiom of the Dignity of the Human Person and in providing answers to the social and economic dilemmas experienced by society.
O DIREITO DE CONSULTA ÉTNICA COMO UM DIREITO HUMANO DOS POVOS INDÍGENAS: CONFIGURAÇÕES DO MARCO REGULATÓRIO INTERNACIONAL E CONSTITUCIONAL – O PROJETO CAPES PRINT NA UNIVERSIDAD DE GRANADA, ESPANHA
Authors: De Araújo Borges Maria Creusa
Published: July 2024

Não obstante a existência de tratados de direitos humanos que protegem os direitos dos povos indígenas, a questão da proteção e da preservação dos territórios alcança centralidade no cenário de construção de empreendimentos hidrelétricos e de mineração. Trata-se de uma questão, não só de desenvolvimento econômico sustentável, mas abrange repercussões no campo da dimensão dos direitos territoriais e educacionais, demandando a configuração de um marco regulatório da consulta étnica como um direito humano dos povos indígenas que promova, juntamente com a educação intercultural, a cidadania. Parte-se do pressuposto que a questão da proteção dos territórios dos povos indígenas se constitui como um problema, ainda, pendente de solução, não obstante a existência de dados oficiais que revelam ser o Brasil um país de presença marcadamente indígena, com um patrimônio cultural constituído por trezentos e cinco etnias e duzentos e setenta e quatro línguas indígenas faladas, indicando a necessidade de realização de pesquisas sociojurídicas sobre a matéria a partir da adoção de uma abordagem normativa multinível e interdisciplinar em que o Direito dialoga com a Sociologia e a Educação. Nesse âmbito, neste artigo, são socializados os resultados do Projeto CAPES PrInt, desenvolvido em regime de colaboração entre a UFPB, Brasil e a Universidad de Granada, Espanha, cujos estudos foram realizados em duas missões de Visiting Scholar, em 2022 e 2023, no Centro de Investigación de Derecho Constitucional “Peter Häberle”, apontando os avanços e os novos direcionamentos da pesquisa.
CONDIÇÕES PARA A CELEBRAÇÃO DO CASAMENTO CIVIL VÁLIDO À LUZ DO ORDENAMENTO JURÍDICO DA GUINÉ-BISSAU: A QUESTÃO DA ACEITAÇÃO OU NÃO DO CASAMENTO DOS HOMOSSEXUAIS EM FACE DO ART. 24 DA CONSTITUIÇÃO DA REPÚBLICA DA GUINÉ-BISSAU
Authors: Insali Victor
Published: July 2024

O presente artigo pretende trazer ao debate a questão das condições para se celebrar validamente um casamento civil nos termos do sistema jurídico da Guiné-Bissau, com real ênfase sobre a problemática da aceitação ou não do casamento dos homossexuais em face do artigo 24 da Constituição da República da Guiné-Bissau, que garante a igualdade de todos os cidadãos perante a lei. Para o efeito, deixa-se de lado outro requisito de fundo do casamento civil, a capacidade dos nubentes, centrando-se apenas na questão da possibilidade legal do casamento civil, nos termos do art. 1577 do Código Civil da Guiné-Bissau, que determina ou só admite a realização do casamento civil entre duas pessoas de sexos diferentes e o consentimento dos nubentes, enquanto também um dos requisitos do casamento civil.
Por uma geografia decolonial: elementos para o ensino de África na educação básica
Authors: Marcelino Jonathan da Silva
Published: July 2024

A proposta desse trabalho é apresentar os marcos de Geografia Decolonial bem como sinalizar para um conjunto de possibilidades pedagógicas que podem ser elaboradas no trabalho com o recorte temático do continente africano nas aulas de Geografia a luz de uma educação antirracista. Sabemos que a Geografia é uma disciplina fundamental para a constituição dos referenciais que orientam os comportamentos dos indivíduos e que ela também é parte dos componentes curriculares obrigatórios na educação básica e pode ser utilizada como instrumento de compreensão das complexidades que envolvem o continente africano, bem como no combate ao racismo, e na construção de uma educação inclusiva.
O papel dos 15+2 na redemocratização angolana (2011-2019): memórias de lutas de um movimento social
Authors: Miguel Oliveira Adão
Published: July 2024

A nossa pesquisa tem como objeto o Grupo dos 15+2 e o seu papel na redemocratização de Angola imbricados às ondas de protestos no Norte de África (Tunísia, Egipto e na Líbia) conhecidas como a ‘’Primavera Árabe’’. Em Angola, o Grupo dos 15+2 emergiu a 20 de Junho de 2015 visando alterar a situação política, económica, social e cultural. Nesse processo, ‘’os movimentos sociais, constituem as vias alternativas, as válvulas de expressão quando os canais institucionais estão excluídos”, como explicita Jelin2. A pesquisa visará estudar o papel dos 15+2 com foco na relação histórico-dialéctica entre história, memória e processos de redemocratização tomando como base a teoria dos marcos sociais e da memória coletiva.
Oxalá cresçam pitangas e É dreda ser angolano: uma análise comparada das construções narrativas de identidades nessas obras
Authors: Cruz Paula Faccini de Bastos
Published: July 2024

Neste artigo buscamos analisar como se constroem as narrativas identitárias da população de Angola, por meio do estudo comparado de suas obras, Oxalá cresçam pitangas (2006) e É dreda ser angolano (2007), do ponto de vista dos seus produtores. Para tanto, estudou-se a formação de uma tradição de filmes de documentário como forma de linguagem cinematográfica nesse país. O discurso identitário sempre se fez presente, transmutando-se com o tempo, em função da mudança do lugar de fala de cada produção. Nesses dois filmes, as narrativas se constroem num país independente, não mais em guerra civil, porém extremamente autoritário, o que determinou graves restrições de censura. Seus produtores são personalidades em evidência na cultura angolana de sua geração: Ondjaki, escritor, ganhador de vários prêmios literários, mostra sua dimensão de cineasta, dividindo a realização de Oxalá com Kiluanje Liberdade, um dos maiores documentaristas angolanos da década de 2010. Dreda foi produzido pela Família Fazuma, um grupo de artistas ativistas políticos, como Pedro Coquenão e Luaty Beirão, hoje membros da resistência ao governo no país.
Considerações sobre o real, simbólico e o imaginário social acerca da loucura na sociedade
Authors: Manoel Antonio de Abreu Pestana dos Santos Douglas , Nunes Hugo Cesar Bueno
Published: July 2024

O objetivo desta contribuição é uma profunda reflexão a respeito da naturalização da loucura e do lugar que ela ocupa no imaginário social. A partir de falas analisadoras e de uma revisão bibliográfica que remonta a história da loucura, busca-se compreende os dispositivos que levam a patologização da diferença e, sobretudo, de que lugar e com qual propósito o saber sobre a loucura é construído. A investigação aponta que a loucura obteve sua qualificação através de uma construção social que defende valores impostos por uma autoritária classe dominante. Ainda reduzida a uma dimensão biológica, a loucura, nessa sociedade que execra a expressão da diferença e da criatividade, continua sendo álibi para o controle e a adequação social, para a promoção de violências sobre os corpos e para a medicalização da vida.
A importância do ensino de história na formação do estudante como indivíduo
Authors: Pereira Heloísa , Gomes Juliana Paula de Oliveira
Published: July 2024

O ensino de história impacta na formação dos estudantes, influenciando o desenvolvimento da identidade individual e coletiva na formação de cidadãos para exercer a cidadania e no desenvolvimento do pensamento crítico. O objetivo do presente artigo é analisar a importância da história na formação da identidade, que começa a ser constituída a partir do contato do indivíduo com o meio social e cultural ao qual está inserido; o impacto na formação para o exercício da cidadania e no desenvolvimento do pensamento crítico, formando o aluno para ser capaz de analisar contextos históricos e realizar reflexões e elaborando conclusões.
Imprensa, pesquisa e ensino de História: impressos digitalizados da hemeroteca digital para estudar a Balaiada na sala de aula
Authors: Almeida Moura Antonio Guanacuy
Published: July 2024

O objetivo deste artigo é apresentar uma breve discussão sobre o uso de impressos digitalizados como fonte para o ensino de História. Inicialmente são explorados apontamentos teóricos que entre os historiadores tem suscitado diversas reflexões e problematizações sobre o uso dos jornais como fonte documental para a área de História. Abordo, ainda, a possibilidade dos docentes de História de usar os jornais em sala de aula acessando os websites que os disponibilizam digitalizados, a exemplo dos jornais, a Chronica Maranhense e o Bem-te-vi, que podem ser utilizados em sala de aula para abordar uma das principais revoltas do período regencial, a Balaiada (1838-1841).Como perspectiva, vislumbro que a aproximação entre historiografia, imprensa, estratégias metodológicas amparadas no digital e ensino pode abrir espaço para novas formas de aprender e ensinar História.
Entre práticas digitais e não digitais: abordagens e perspectivas no ensino de história (Apresentação do Dossiê)
Authors: Debom Paulo , Cupello Peixoto Rafael , De Almeida Lourenço Cardoso Pires Thiago
Published: July 2024

Apresentação do Dossiê da Revista Veredas da História, v. 15, n, 1, 2023
Editorial
Authors: Celestino de Jesus Cassiano , Pereira Lima Marcelo
Published: July 2024

Editorial da Revista Veredas da História, v. 15, n.1
Narrativas visuais de trabalhadoras de São Paulo (1940): perspectivas fotográficas de Hildegard Rosenthal
Authors: Lysakowski Hallal Maria Clara
Published: July 2024

O princípio balizador deste trabalho é o registro visual de uma fotógrafa imigrante – Hildegard Rosenthal – sobre as mulheres trabalhadoras que ocupavam a urbe paulistana. Logo, o objetivo do artigo é analisar como Hildegard Rosenthal construiu narrativas visuais das trabalhadoras que ocupavam São Paulo na década de 1940. Para a análise das fotografias ser efetiva, adapto o método proposto por Augusto Pieroni (2003), e divido a apreciação em formas e conteúdos. Como resultados esperados, compreendo que as narrativas visuais que Hildegard Rosenthal construiu das mulheres que ocupavam a urbe paulistana era diversificada, por vezes, não podemos negar, classista. Mas Hildegard Rosenthal buscou retratar as mais variadas ocupações, o que permite, na atualidade, termos um repertório diverso das mulheres trabalhadoras que constituíam a cidade de São Paulo nos anos 1940.
Nanocontainer‐Based Anticorrosive Coatings: Effect of the Container Size on the Self‐Healing Performance
Authors: Borisova Dimitriya , Akçakayıran Dilek , Schenderlein Matthias , Möhwald Helmuth , Shchukin Dmitry G.
Published: March 2013

Organic coatings based on inhibitor loaded inorganic containers for smart corrosion inhibition are presented. The overall coating performance is strongly influenced by the containers as well as their inhibitor capacity, compatibility with the coating matrix, and size. The important effect of container size is described for the first time in this work by investigating two types of mesoporous silica containers of different diameters: 80 and 700 nm. The coating physical properties (thickness and adhesion) are comparable for both container types. In contrast, the coating barrier properties are strongly influenced by the container size as assessed with electrochemical impedance spectroscopy (EIS). The incorporation of bigger containers reduces the coating resistance by a factor of two. Surprisingly, despite the similar amounts (20 wt%) of loaded inhibitor (2‐mercaptobenzothiazole), different active inhibition ability is detected with the scanning vibrating electrode technique (SVET). Therefore, it is found that coatings with smaller containers exhibit better self‐healing performance.
Photolabile Protecting Groups: Structure and Reactivity
Authors: Wang Pengfei
Published: March 2013

This Review focuses on the structure‐reactivity relationship of three main classes of photolabile protecting groups (PPGs), that is, the 2‐nitrobenzyl (NB) series of PPGs, carbonyl‐based PPGs, and benzyl‐based PPGs. Recent efforts in developing new PPGs for protection of carbonyl and hydroxy groups are also discussed.
Bioindicator role of aquatic Ranunculus in Mediterranean freshwater habitats
Authors: Lumbreras Ana , Pardo Cristina , Molina José Antonio
Published: March 2013

Mediterranean freshwater ecosystems are among the most endangered by global change. In order to design appropriate conservation policies it is essential to ascertain which are the most vulnerable freshwater habitats.

Aquatic Ranunculus communities are used as target habitats to answer the following questions: (a) Does regional climate influence the distribution of aquatic plant communities? (b) Do nutrient enriched and base‐rich waters act as a filter for aquatic habitats, reducing the number of plant communities? and (c) Is the European Habitats Directive classification for freshwater habitats that support Ranunculus species fit for purpose?

The floristic consistency of nine Ranunculus communities and their affinity with freshwater ecosystem types was analysed. A study was made of the relationships between environmental factors, including climate and aquatic physico‐chemical parameters, and the composition of Ranunculus communities. Significant environmental parameters were analysed separately to define the ecological niche occupied by Ranunculus species.

At a regional scale, climatic variables best explain the distribution patterns of the Ranunculus communities, and separate Atlantic communities (Ranunculus tripartitus, R. omiophyllus, R. ololeucos and R. fluitans communities) at localities with a higher rainfall/temperature ratio from the rest. At a local scale, a strong relationship was found between the distribution of Ranunculus communities and physico‐chemical properties, in the following order of importance: alkalinity, flow, and nutrient status. Hard waters reduce Ranunculus community richness to a R. trichophyllus community, and waters enriched by phosphates to a R. penicillatus community.

The rainfall/temperature ratio, alkalinity, and eutrophication shape the vegetation composition in Mediterranean freshwater habitats. In view of this, some gaps were identified in the European Habitats Directive with regard to Atlantic and oligotrophic base‐poor freshwater habitats.

Copyright © 2013 John Wiley & Sons, Ltd.
Carbimazole embryopathy in a Chinese population: Case series and literature review
Authors: Ting Yuen Ha , Zhou Yan , Lao Terence T.
Published: March 2013

BACKGROUND

The data in the literature suggests that Methimazole (MMI)/Carbimazole (CMZ) embryopathy is rare. This study examined the incidence of CMZ embryopathy in the Hong Kong Chinese population and the factors associated with its development.

METHODS

Of the 145 pregnant women with hyperthyroidism managed from 2008 to 2010, 29 (20%) had taken CMZ during pregnancy. The presence and details of birth defects, the dosage of CMZ, and the period of exposure during pregnancy were examined in these 29 pregnancies. All cases of CMZ embryopathy in the English literature were reviewed in the same way.

RESULTS

Of the 27 babies (93.1%) with known outcome, 3 had aplasia cutis and 1 had an omphalocele in addition, and 1 affected baby had a sibling with aplasia cutis and patent vitellointestinal duct. The incidence of CMZ embryopathy in our study group is 11.1%. Amongst the 21 cases of CMZ embryopathy in the literature, 85% were exposed to a CMZ dosage of ≥20 mg/day, and the minimum duration of exposure being 7 weeks from last menstrual period. The most common abnormality is ectodermal anomaly (62%), followed by oro‐nasal anomaly (48%), facial dysmorphism (38%), gastrointestinal anomaly (33%) and abdominal wall defect (19%). There was no relationship between the type of abnormality and the dosage or duration of exposure to CMZ.

CONCLUSIONS

The incidence of CMZ embryopathy in our study group is 11.1%. Critical factors for its development are exposure to a CMZ dosage of ≥20 mg/day before 7 weeks of gestation. Genetic susceptibility may also play a role. Birth Defects Research (Part A) 97:225–229, 2013. © 2013 Wiley Periodicals, Inc.
Vom Nutzen der Historie für die Wissenschaftsphilosophie
Authors: Schickore Jutta
Published: March 2013

Of the Merits of History for Philosophy of Science. This essay is inspired by some of the contributions to the two special issues “History of Science and Philosophy of Science” of the journal Berichte zur Wissenschaftsgeschichte. I consider possible roles of historical study for philosophy of science. The first part of the essay discusses contributions to the Anglo‐American debate about history and philosophy of science in the 1960s and 1970s. I present two approaches. According to Larry Laudan and others, philosophy of science should be regarded as an empirical theory of science, which has to be tested against historical episodes. I show why this conception of philosophy of science is problematic. According to Dudley Shapere and others, by contrast, philosophical analysis of science requires hermeneutic understanding and should include the study of the development of scientific knowledge. I agree that the method of philosophy of science is best described as hermeneutic. To defend a genuine historical‐hermeneutic philosophy of science, however, one would have to demonstrate the privilege of historical analysis over other forms of science studies, such as sociology of science or studies of science communication. I do not think that such a demonstration can be made.
Mitochondrial dysfunction in psychiatric and neurological diseases: Cause(s), consequence(s), and implications of antioxidant therapy
Authors: Kasote Deepak M. , Hegde Mahabaleshwar V. , Katyare Surendra S.
Published: March 2013

Mitochondrial dysfunction is at the base of development and progression of several psychiatric and neurologic diseases with different etiologies. MtDNA/nDNA mutational damage, failure of endogenous antioxidant defenses, hormonal malfunction, altered membrane permeability, metabolic dysregulation, disruption of calcium buffering capacity and ageing have been found to be the root causes of mitochondrial dysfunction in psychatric and neurodegenerative diseases. However, the overall consequences of mitochondrial dysfunction are only limited to increase in oxidative/nitrosative stress and cellular energy crises. Thus far, extensive efforts have been made to improve mitochondrial function through specific cause‐dependent antioxidant therapy. However, owing to complex genetic and interlinked causes of mitochondrial dysfunction, it has not been possible to achieve any common, unique supportive antioxidant therapeutic strategy for the treatment of psychiatric and neurologic diseases. Hence, we propose an antioxidant therapeutic strategy for management of consequences of mitochondrial dysfunction in psychiatric and neurologic diseases. It is expected that this will not only reduces oxidative stress, but also promote anaerobic energy production. © 2013 BioFactors, 39(4):393–407, 2013
Left hepatic trisectionectomy for advanced perihilar cholangiocarcinoma
Authors: Esaki M , Shimada K , Nara S , Kishi Y , Sakamoto Y , Kosuge T , Sano T
Published: March 2013

Background

Data on outcomes of left hepatic trisectionectomy (LT) for perihilar cholangiocarcinoma are limited. The aim of this study was to clarify short- and long-term outcomes of LT for perihilar cholangiocarcinoma.

Methods

Patients with perihilar cholangiocarcinoma who underwent LT between January 2000 and October 2011 were analysed. Surgical variables, mortality, morbidity (Clavien grade I–V), recurrence sites and survival were compared between subjects who underwent LT, right hemihepatectomy or left hemihepatectomy.

Results

A total 214 patients underwent resection for perihilar cholangiocarcinoma, 25 (11·7 per cent) of whom underwent LT, 88 (41·1 per cent) right hemihepatectomy and 94 (43·9 per cent) left hepatectomy. There were no deaths among those who had LT, but 20 patients developed complications. The incidence of grade IIIa complications was significantly higher among patients who underwent LT than in patients who had right or left hemihepatectomy (P = 0·001 and P < 0·001 respectively). Only one patient developed a grade IIIb or IV complication (liver failure) after LT. The overall 5-year survival rate after LT was 39 per cent and median survival was 45 months. There were no significant differences in survival between patients who underwent LT and those who had a right or left hemihepatectomy.

Conclusion

LT may provide a good outcome for advanced perihilar cholangiocarcinoma.
Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra‐performance liquid chromatography–tandem mass spectrometry and its application to pharmacokinetic study in humans
Authors: Huang Pei‐Wei , Liu Hung‐Ta , Hsiong Cheng‐Huei , Pao Li‐Heng , Lu Chih‐Cherng , Ho Shung‐Tai , Hu Oliver Yoa‐Pu
Published: March 2013

A rapid, simple, sensitive and selective ultraperformance liquid chromatography–tandem spectrometry (UPLC‐MS/MS) method for the determination of nalbuphine and its prodrug sebacoly dinalbuphine ester (SDE) was developed and validated in human plasma. The sample pretreatment involves basification and iterative liquid–liquid extraction with ethyl‐ether–dichloromethane (7:3, v/v) solution, followed by LC separation and positive electrospray ionization (ESI) API‐3000 mass spectrometry detection. The chromatography was on a Waters Acquity UPLC BEH HILIC column (2.1 × 100 mm, 1.7 µm). The mobile phase was composed of acetonitrile and water (83:17, v/v) that contained 0.2% formic acid and 4 mm ammonium formate at a flow rate of 0.25 mL/min. Ethylmorphine and naloxine were selected as the SDE and nalbuphine internal standard (IS), respectively. The calibration curve for both was linear over the range from 0.05 to 20 ng/mL, with correlation coefficients ≥0.995. The lower limit of quantification was set at 0.05 ng/mL. The intra‐ and inter‐day precision values for nalbuphine and SDE were acceptable as per FDA guidelines. The method was applied successfully to determine nalbuphine concentration in human plasma samples obtained from four Taiwanese volunteers receiving intramuscularly administration of sebacoyl dinalbuphine ester. The method is sensitive, selective and directly applicable to human pharmacokinetic studies involving nalbuphine. Copyright © 2013 John Wiley & Sons, Ltd.
Safety and feasibility of orbital atherectomy for the treatment of calcified coronary lesions
Authors: Parikh Keyur , Chandra Praveen , Choksi Nishit , Khanna Puneet , Chambers Jeffrey
Published: March 2013

Objective: The ORBIT I trial evaluated the safety and performance of an orbital atherectomy system (OAS) for the treatment of de novo calcified coronary lesions. Background: Severely calcified coronary arteries pose an ongoing treatment challenge. Stent placement in calcified lesions can result in stent under expansion, malapposition, and procedural complications. OAS treatment may change calcified lesion compliance to reduce procedural complications and facilitate stent placement. Methods: The ORBIT I trial, a prospective, nonrandomized study, was conducted in two centers in India. Fifty patients with de novo calcified coronary lesions were enrolled. Patients were treated with the OAS followed by stent placement. Results: The average age of the patients was 57.4 years and 90% were male. Mean lesion length was 13.4 mm. The average number of OAS devices used per patient was 1.3. Device success was 98%, and procedural success was 94%. The cumulative major adverse cardiac event rate was 4% in‐hospital (two non–Q‐wave myocardial infarctions), 6% at 30 days (one additional non–Q‐wave myocardial infarction leading to target lesion revascularization), and 8% at 6 months (one additional event of cardiac death). Angiographic complications were observed in seven patients (six dissections and one perforation). Conclusion: The ORBIT I trial suggests that the OAS may offer an effective method to change compliance of calcified coronary lesions to facilitate optimal stent placement in these difficult to treat patients. A larger trial is required to establish safety and overall effectiveness of the OAS in treating calcified coronary lesions. © 2012 Wiley Periodicals, Inc.
Preparation of Gradient Surfaces by Using a Simple Chemical Reaction and Investigation of Cell Adhesion on a Two‐Component Gradient
Authors: Lee Jeongwook , Choi Inseong , Yeo Woon‐Seok
Published: March 2013

This article describes a simple method for the generation of multicomponent gradient surfaces on self‐assembled monolayers (SAMs) on gold in a precise and predictable manner, by harnessing a chemical reaction on the monolayer, and their applications. A quinone derivative on a monolayer was converted to an amine through spontaneous intramolecular cyclization following first‐order reaction kinetics. An amine gradient on the surface on a scale of centimeters was realized by modulating the exposure time of the quinone‐presenting monolayer to the chemical reagent. The resulting amine was used as a chemical handle to attach various molecules to the monolayer with formation of multicomponent gradient surfaces. The effectiveness of this strategy was verified by cyclic voltammetry (CV), matrix assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF) mass spectrometry (MS), MS imaging, and contact‐angle measurements. As a practical application, cell adhesion was investigated on RGD/PHSRN peptide/peptide gradient surfaces. Peptide PHSRN was found to synergistically enhance cell adhesion at the position where these two ligands are presented in equal amounts, while these peptide ligands were competitively involved in cell adhesion at other positions. This strategy of generating a gradient may be further expandable to the development of functional gradient surfaces of various molecules and materials, such as DNA, proteins, growth factors, and nanoparticles, and could therefore be useful in many fields of research and practical applications.
Artificial Allosteric Receptors
Authors: Kremer Christopher , Lützen Arne
Published: March 2013

Cooperative effects in the binding of two or more substrates to different binding sites of a receptor that are a result of a conformational change caused by the binding of the first substrate—also referred to as the effector—are called allosteric effects. In biological systems, allosteric regulation is a widely used mechanism to control the function of proteins and enzymes in cellular metabolism. Inspired by this a lot of efforts have been made in supramolecular chemistry to implement this concept into artificial systems to control functions as molecular recognition, signal amplification, or even reactivity and catalysis. This review gives an up‐to‐date overview over the different approaches that have been reported ever since the first examples from the late 1970s/early 1980s. It covers both homo‐ and heterotropic examples and is divided according to the nature of the effector—cationic, anionic, or neutral—effectors and systems that use combinations of those.
ChemInform Abstract: Enhanced Blue Luminescence in BaMgAl10O17: Eu, Er, Nd Nanophosphor for PDPs and Mercury‐Free Fluorescent Lamps.
Authors: Yadav Raghvendra S. , Shukla Vineet K. , Mishra Priya , Pandey Shiv K. , Kumar Kausal , Baranwal Vikas , Kumar Manvendra , Pandey Avinash C.
Published: March 2013

Er3+/Nd3+ codoped BaMgAl10O17:Eu2+ phosphor nanoparticles are prepared by a solution combustion method starting with of Ba(NO3)2, Al(NO3)3, Mg(NO3)2, Eu(NO3)3, ErCl2, Nd(NO3)3, and urea dissolved in water (400 °C, 4—6 min).
ChemInform Abstract: LiBC —Synthesis, Electrochemical and Solid‐State NMR Investigations.
Authors: Langer Thorsten , Dupke Sven , Dippel Christian , Winter Martin , Eckert Hellmut , Poettgen Rainer
Published: March 2013

LiBC is synthesized from the elements (Nb ampule, 700 mbar Ar, 1800 K for 15 min, 1000 K for 2 h) and characterized by powder and single crystal XRD and 6/7Li and 11B solid state NMR spectroscopy.
ChemInform Abstract: New Form of Li2FePO4F as Cathode Material for Li‐Ion Batteries.
Authors: Khasanova Nellie R. , Drozhzhin Oleg A. , Storozhilova Darya A. , Delmas Claude , Antipov Evgeny V.
Published: March 2013

NaLiFePO4F is prepared by annealing a stoichiometric mixture of LiFePO4 and NaF (Ar flow, 650—700 °C, 2 h).
ChemInform Abstract: Preparation and Characterization of a Stable FeSO4F‐Based Framework for Alkali Ion Insertion Electrodes.
Authors: Recham Nadir , Rousse Gwenaelle , Sougrati Moulay T. , Chotard Jean‐Noel , Frayret Christine , Mariyappan Sathiya , Melot Brent C. , Jumas Jean‐Claude , Tarascon Jean‐Marie
Published: March 2013

KMSO4F (M: Fe, Co, Ni) is prepared by ball milling of equimolar mixtures of KF and MSO4 for one hour followed by heating (Parr reactor, 270—290 °C, 40—45 h).
ChemInform Abstract: Template‐Free Synthesis of Mesoporous Transition Metal Nitride Materials from Ternary Cadmium Transition Metal Oxides.
Authors: Yang Minghui , DiSalvo Francis J.
Published: March 2013

Mesoporous NbN, VN, Ta3N5, and TiN are prepared by ammonolysis of Cd2Nb2O7, Cd4V2O9, Cd2Ta2O7, and CdTiO3 (flowing NH3 gas, alumina boats, 450—800 °C, 8—30 h).
ChemInform Abstract: Making Practical Use of the Pseudo‐Element Concept: An Efficient Way to Ternary Intermetalloid Clusters by an Isoelectronic Pb‐—Bi Combination.
Authors: Ababei Rodica , Heine Johanna , Holynska Malgorzata , Thiele Guenther , Weinert Bastian , Xie Xiulan , Weigend Florian , Dehnen Stefanie
Published: March 2013

The synthetic use of pseudo‐homoatomic Pb‐—Bi Zintl anions as an efficient approach to the first M@Pb—Bi ternary intermetalloid clusters with reasonable yields is demonstrated.
ChemInform Abstract: A Novel LaFeO3‐xNx Oxynitride. Synthesis and Characterization.
Authors: Gallego G. Sierra , Alzate N. Marin , Arnache O.
Published: March 2013

The title compound is prepared by ammonolysis of LaFeO3 in a stream of NH3 using N2 as carrier gas (900°C, 72 h).
ChemInform Abstract: Copper‐Rich Intermetallic Compounds RECu9Cd2(RE: La, Ce, Pr, Nd) with YNi9In2‐Type Structure.
Authors: Johnscher Michael , Poettgen Rainer
Published: March 2013

The title compounds are synthesized by reaction of stoichiometric mixtures of the elements (sealed Nb ampules, induction furnace, 1400 K, 10 min; annealing at 900 K, 4 h).
ChemInform Abstract: Mesoporous Cross‐Linked Polymer Copolymerized with Chiral BINAP Ligand Coordinated to a Ruthenium Species as an Efficient Heterogeneous Catalyst for Asymmetric Hydrogenation.
Authors: Sun Qi , Meng Xiangju , Liu Xiao , Zhang Xiaoming , Yang Yan , Yang Qihua , Xiao Feng‐Shou
Published: March 2013

A heterogeneous chiral catalyst, obtained by copolymerization of divinylbenzene with a chiral BINAP ligand followed by coordination of the BINAP ligand with a ruthenium species, exhibits high activity, excellent enantioselectivity and extraordinary recyclability in asymmetric hydrogenation of β‐keto esters.
ChemInform Abstract: Highly Dispersed Palladium Nanoparticles on Mesocellular Foam: An Efficient and Recyclable Heterogeneous Catalyst for Alcohol Oxidation.
Authors: Johnston Eric V. , Verho Oscar , Kaerkaes Markus D. , Shakeri Mozaffar , Tai Cheuk‐Wai , Palmgren Paal , Eriksson Kristofer , Oscarsson Sven , Baeckvall Jan‐E.
Published: March 2013

Palladium on siliceous mesocellular foam is a highly active and stable catalyst for oxidation of primary and secondary (benzylic) alcohols.
ChemInform Abstract: Chemoselective Hydrogenation Using Molecular Sieve Supported Pd Catalysts: Pd/MS3A and Pd/MS5A.
Authors: Takahashi Tohru , Yoshimura Masatoshi , Suzuka Hiroyasu , Maegawa Tomohiro , Sawama Yoshinari , Monguchi Yasunari , Sajiki Hironao
Published: March 2013

The catalysts are prepared and tested in the hydrogenation of olefins, alkynes, and azides.
ChemInform Abstract: Organocatalytic Oxidative Dehydrogenation of Aromatic Amines for the Preparation of Azobenzenes under Mild Conditions.
Authors: Ma Hengchang , et al. et al.
Published: March 2013

Ph‐I(O‐Ac)2 or Ac‐O‐OH in combination with catalytic amounts of o‐iodobenzoic acid are employed for the novel process.
ChemInform Abstract: Controlled Coupling of Quinone Monoacetals Using Reusable Polystyrene‐Anchored Specific Proton Catalyst.
Authors: Dohi Toshifumi , Hu Yinjun , Kamitanaka Tohru , Kita Yasuyuki
Published: March 2013

A unique solid acid catalyst PBA is developed and efficiently employed for the coupling of quinone monoacetals with olefins and other nucleophiles.
ChemInform Abstract: Asymmetric Formal Carbonyl‐Ene Reactions of Formaldehyde tert‐Butyl Hydrazone with α‐Keto Esters. Dual Activation by Bis‐urea Catalysts.
Authors: Crespo‐Pena Ana , Monge David , Martin‐Zamora Eloisa , Alvarez Eleuterio , Fernandez Rosario , Lassaletta Jose M.
Published: March 2013

Reaction of α‐keto esters with hydrazone (IV) is efficiently promoted by binaphthyl‐derived bis‐urea catalysts (I) and (II).
ChemInform Abstract: Palladium(II) Complexes with Aminomethylphosphine Ligands as Catalysts for the Heck Reaction.
Authors: Keles Mustafa , Yilmaz Mustafa Kemal
Published: March 2013

The new complexes (I) are tested in Heck reactions of activated and deactivated aryl halides with various olefins.
ChemInform Abstract: Cyclization of (2‐Alkenylphenyl)carbonyl Compounds to Polycyclic Arenes Catalyzed by Copper(II) Trifluoromethanesulfonate or Trifluoromethanesulfuric Acid.
Authors: Liu Wei‐Min , Tnay Ya Lin , Gan Kian Ping , Liu Zhen‐Hong , Tyan Wan Huei , Narasaka Koichi
Published: March 2013

Various polycyclic arenes are efficiently synthesized using different (alkenylphenyl)carbonyl compounds as starting materials.
ChemInform Abstract: An Expedient Approach to Highly Enantioenriched Cyclic Nitrones Mediated by Robust and Recoverable C3‐Symmetric Cinchonine‐Squaramide Catalysts.
Authors: Han Xin , Wu Xiangfei , Min Chang , Zhou Hai‐Bing , Dong Chune
Published: March 2013

Derivative (I) is found to be an efficient reusable catalyst for the asymmetric Michael addition of β‐ketosulfones to nitroalkenes.
ChemInform Abstract: Synthesis of (E)‐2,5‐Disubstituted 1,3,4‐Thiadiazolyl‐2,3‐diphenylpropenones from Alkenylidene‐Hydrazinecarbothioamides.
Authors: Hassan Alaa A. , Abdel‐Latif Fathy F. , Nour El‐Din Ahmed M. , Mostafa Sara M. , Nieger Martin , Braese Stefan
Published: March 2013

Conjugate addition of thioamides (I) to diphenylcyclopropenones and subsequent heterocyclization provide the title compounds in good yields.
ChemInform Abstract: Reaction of 2‐Aza‐1,3,5‐trienes with Superbases: An Unexpected Approach Towards Exomethylene Tetrahydroazepines.
Authors: Nedolya N. A. , Volostnykh O. G. , Tarasova O. A. , Albanov A. I. , Trofimov B. A.
Published: March 2013

The synthesis of a first example of 2‐ethylidene‐3,4,5,6‐tetrahydro‐2H‐azepines is described.
ChemInform Abstract: One‐Pot Gold‐Catalyzed Synthesis of Azepino[1,2‐a]indoles.
Authors: Cera Gianpiero , Piscitelli Stefano , Chiarucci Michel , Fabrizi Giancarlo , Goggiamani Antonella , Ramon Ruben S. , Nolan Steven P. , Bandini Marco
Published: March 2013

2‐Alkynylanilines undergo a 5‐endo‐dig hydroamination/dehydration sequence to provide 2‐vinylindole intermediates.
ChemInform Abstract: Reaction of Hydrosilanes with Alkynes Catalyzed by Gold Nanoparticles Supported on TiO2.
Authors: Psyllaki Androniki , Lykakis Ioannis N. , Stratakis Manolis
Published: March 2013

The hydrosilylation of terminal alkynes under conditions A) affords predominantly β‐(E)‐isomers.
ChemInform Abstract: Monopoles in Ferromagnetic Metals
Authors: Tatara Gen , Takeuchi Akihito , Nakabayashi Noriyuki , Taguchi Katsuhisa
Published: March 2013

Review: 47 refs.
ChemInform Abstract: Nanostructured Multiferroics
Authors: Hajra Partha , Maiti Ramaprasad , Chakravorty Dipankar
Published: March 2013

Review: 66 refs.
ChemInform Abstract: Sixty Years Young: The Diverse Biological Activities of Metal Polypyridyl Complexes Pioneered by Francis P. Dwyer
Authors: Kilah Nathan L. , Meggers Eric
Published: March 2013

Review: 53 refs.
ChemInform Abstract: Molecular Early Main Group Metal Hydrides: Synthetic Challenge, Structures and Applications
Authors: Harder Sjoerd
Published: March 2013

Review: 99 refs.
ChemInform Abstract: Mechanisms of Reactions of Organoaluminum Compounds with Alkenes and Alkynes Catalyzed by Zr Complexes
Authors: Parfenova L. V. , Khalilov L. M. , Dzhemilev U. M.
Published: March 2013

Review: 233 refs.
ChemInform Abstract: Synthesis of Selenophenes Condensed with Six‐Membered Nitrogen Heterocycles
Authors: Vasiljeva E. , Arsenyan P.
Published: March 2013

Review: 60 refs.
ChemInform Abstract: Polyoxometalates as Homogeneous Oxidation Catalysts
Authors: Carraro Mauro , Sartorel Andrea , Ibrahim Masooma , Nsouli Nadeen , Jahier Claire , Nlate Sylvain , Kortz Ulrich , Bonchio Marcella
Published: March 2013

Review: 175 refs.
ChemInform Abstract: Supported Ionic Liquids on Non‐Porous and Porous Inorganic Materials
Authors: Selvam Thangaraj , Machoke Albert , Schwieger Wilhelm
Published: March 2013

Review: 155 refs.
ChemInform Abstract: Organoselenium and Organotellurium Oxidation and Reduction
Authors: Mlochowski Jacek , Lisiak Rafal , Wojtowicz‐Mlochowska Halina
Published: March 2013

Review: 543 refs.
ChemInform Abstract: Functional Groups Containing Selenium and Tellurium in Oxidation States from 3 to 6
Authors: Midura Wanda H. , Kielbasinski Piotr , Drabowicz Jozef
Published: March 2013

Review: 227 refs.
ChemInform Abstract: Phosphorothioate Nucleotides and Oligonucleotides‐Recent Progress in Synthesis and Application
Authors: Guga Piotr , Koziolkiewicz Maria
Published: March 2013

Review: 217 refs.
ChemInform Abstract: Asymmetric Organocatalyzed Morita—Baylis—Hillman Reactions
Authors: Guillena Gabriela , Ramon Diego J. , Yus Miguel
Published: March 2013

Review: 129 refs.
ChemInform Abstract: The Bronsted Acid/Base Character of Hydroxylamines, Oximes and Hydroxamic Acids
Authors: Bartmess John E.
Published: March 2013

Review: 119 refs.
ChemInform Abstract: Heterocyclic‐Functionalized Organic Dyes for Dye‐Sensitized Solar Cells: Tuning Solar Cell Performance by Structural Modification
Authors: Li Qianqian , Jiang Zhongxing , Qin Jingui , Li Zhen
Published: March 2013

Review: 72 refs.
ChemInform Abstract: A Rudimentary Method for Classification of π—π Packing Motifs for Aromatic Molecules
Authors: Loots Leigh , Barbour Leonard J.
Published: March 2013

Review: 36 refs.
Bioavailability of Clindamycin From a New Clindamycin Phosphate 1.2%–Benzoyl Peroxide 3% Combination Gel
Authors: Jones Terry M. , Jasper Stacy , Alió Sáenz Alessandra B.
Published: March 2013

A new topical fixed‐dose combination product containing clindamycin (1%, formulated as 1.2% clindamycin phosphate, CLNP 1.2%) with low strength (3%) benzoyl peroxide (BPO) in a methylparaben‐free gel vehicle (CLNP 1.2%–BPO 3%‐MPF) has been developed for the treatment of acne. The objective of this study was to determine the relative bioavailability of clindamycin and clindamycin sulfoxide from CLNP 1.2%–BPO 3%‐MPF compared with clindamycin phosphate 1.2%‐BPO 5% in a methylparaben‐preserved gel vehicle (CLNP 1.2%–BPO 5%‐MP) and clindamycin phosphate 1.2%–BPO 5% in a methylparaben‐free gel vehicle (CLNP 1.2%–BPO 5%‐MPF), and to determine whether exposure is affected by BPO concentration (3% vs. 5%) when applied topically. Seventy‐two subjects with moderate–severe acne were randomized to receive CLNP 1.2%‐BPO 3%‐MPF, CLNP 1.2%–BPO 5%‐MP, or CLNP 1.2%–BPO 5%‐MPF in a 5‐day, open‐label, and parallel‐group study. Cmax and AUC values for clindamycin were highest for CLNP 1.2%–BPO 5%‐MP, followed by CLNP 1.2%–BPO 3%‐MPF and CLNP 1.2%–BPO 5%‐MPF, but differences were not statistically significant. Systemic exposure to clindamycin and clindamycin sulfoxide was low and comparable between the formulations. Results indicate that differences in BPO concentration do not influence clindamycin bioavailability.
Electrooxidation in Alkaline Media of Ethylene Glycol and Glycerol on Pd‐(Ni‐Zn)/C Anodes in Direct Alcohol Fuel Cells
Authors: Marchionni Andrea , Bevilacqua Manuela , Bianchini Claudio , Chen Yan‐Xin , Filippi Jonathan , Fornasiero Paolo , Lavacchi Alessandro , Miller Hamish , Wang Lianqin , Vizza Francesco
Published: March 2013

Invited for this month’s cover is the group of Francesco Vizza at ICCOM‐CNR in Florence. The image shows a direct alcohol fuel cell that acts as a chemical reactor for the sustainable production of energy and chemicals. Read the full text of the article at http://dx.doi.org/10.1002/cssc.201200866.
A computational platform for robotized fluorescence microscopy (I): High‐content image‐based cell‐cycle analysis
Authors: Furia Laura , Pelicci Pier Giuseppe , Faretta Mario
Published: March 2013

Hardware automation and software development have allowed a dramatic increase of throughput in both acquisition and analysis of images by associating an optimized statistical significance with fluorescence microscopy. Despite the numerous common points between fluorescence microscopy and flow cytometry (FCM), the enormous amount of applications developed for the latter have found relatively low space among the modern high‐resolution imaging techniques. With the aim to fulfill this gap, we developed a novel computational platform named A.M.I.CO. (Automated Microscopy for Image‐Cytometry) for the quantitative analysis of images from widefield and confocal robotized microscopes. Thanks to the setting up of both staining protocols and analysis procedures, we were able to recapitulate many FCM assays. In particular, we focused on the measurement of DNA content and the reconstruction of cell‐cycle profiles with optimal parameters. Standard automated microscopes were employed at the highest optical resolution (200 nm), and white‐light sources made it possible to perform an efficient multiparameter analysis. DNA‐ and protein‐content measurements were complemented with image‐derived information on their intracellular spatial distribution. Notably, the developed tools create a direct link between image‐analysis and acquisition. It is therefore possible to isolate target populations according to a definite quantitative profile, and to relocate physically them for diffraction‐limited data acquisition. Thanks to its flexibility and analysis‐driven acquisition, A.M.I.CO. can integrate flow, image‐stream and laser‐scanning cytometry analysis, providing high‐resolution intracellular analysis with a previously unreached statistical relevance. © 2013 International Society for Advancement of Cytometry © 2012 International Society for Advancement of Cytometry
Gene–environment interaction between DRD4 7‐repeat VNTR and early child‐care experiences predicts self‐regulation abilities in prekindergarten
Authors: Berry Daniel , McCartney Kathleen , Petrill Stephen , Deater‐Deckard Kirby , Blair Clancy
Published: March 2013

Intervention studies indicate that children's early child‐care experiences can be leveraged to foster their development of effective self‐regulation skills. It is less clear whether typical child‐care experiences play a similar role. In addition, evidence suggests that children with a common variant of the DRD4 gene (48‐bp VNTR, 7‐repeat) may be more sensitive to their experiences than those without this variant. Using data from theNICHD Study of Early Child Care and Youth Development, we considered the degree to which children's early child‐care experiences—quantity, quality, and type—were associated with their attention and self‐regulation abilities in prekindergarten, and, in particular, whether these relations were conditional on DRD4 genotype. G × E interactions were evident across multiple neuropsychological and observational measures of children's attention and self‐regulation abilities. Across most outcome measures, DRD4 7+ children spending fewer hours in child care showed more effective attention/self‐regulation abilities. For those without a copy of the DRD4 7‐repeat allele, such associations were typically null. The results for child‐care quality and type indicated no interactions with genotype; the main‐effect associations were somewhat inconsistent. © 2013 Wiley Periodicals, Inc. © 2013Wiley Periodicals, Inc. Dev Psychobiol 56: 373–391, 2014.