bluuebunny/crossref_metadata_2025 huggingface dataset:
Partitioning autotrophic and heterotrophic respiration in an ombrotrophic bog
Authors: Rankin Tracy , Roulet Nigel , Humphreys Elyn , Peichl Matthias , Jӓrveoja Jӓrvi
Published: November 2023

Northern peatlands are globally significant carbon stores, but the sink strength varies from year to year due to changes in environmental conditions. Ecosystem respiration (ER) is composed of both autotrophic respiration (AR) that consists of respiration by plant parts, and heterotrophic respiration (HR) that consists of respiration by microbial bacteria in the soil, fungi, etc. Manual measurements only crudely partition AR and HR, which may lead to erroneous estimates if a change favours one form of respiration over another and may influence our interpretation in the magnitude of respiration. HR has also been thought to be more linked to vegetation dynamics, particularly in wetter, sedge-dominated ecosystems like fens. It is unknown whether such plant-soil-root interactions influence HR in peatlands dominated by woody shrubs whose water table is located further below the surface. The objectives of this study were to 1) determine the contributions of AR and HR at Mer Bleue, an ombrotrophic bog, 2) explore how environmental conditions influence ER and its components, 3) determine how different methodological approaches (e.g. directly measured respiration using automatic chambers vs. extrapolated calculations) can influence our interpretation in the magnitude of respiration, and 4) compare the respiration dynamics with those found in the literature for other peatland types. Our results revealed differences in AR and HR contributions to ER compared to other peatland types reported in the literature. The AR/HR ratio was 3.0 and AR contributions to ER were ∼75% at our study bog, which is generally higher than AR contributions from fens, but also decreased substantially during extended drier periods. HR contributions increased with rising temperature and water table depth. Directly measured ER was smaller than when ER was estimated using night-time relationships with temperature. The magnitude of ER changed depending on the plant biomass, which we believe to be a result of vegetation dynamics influencing HR. The results of this study improved our understanding of peatland carbon cycling as well as the conceptualization of HR.
Patterns of de novo metastasis and survival outcomes by age in breast cancer patients: a SEER population-based study
Authors: Xiao Qian , Zhang Weixiao , Jing Jingfeng , Zhong Tingting , Li Daxue , Zhou Jing , Liu Pan , Duan Zhongxu , Gao Han , Shen Liyuan
Published: November 2023

Background

The role of age in metastatic disease, including breast cancer, remains obscure. This study was conducted to determine the role of age in patients with de novo metastatic breast cancer.

Methods

Breast cancer patients diagnosed with distant metastases between 2010 and 2019 were retrieved from the Surveillance, Epidemiology, and End Results database. Comparisons were performed between young (aged ≤ 40 years), middle-aged (41–60 years), older (61–80 years), and the oldest old (> 80 years) patients. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were estimated using multivariate Cox proportional hazard models. Survival analysis was performed by the Kaplan–Meier method.

Results

This study included 24155 (4.4% of all patients) de novo metastatic breast cancer patients. The number of young, middle-aged, older, and the oldest old patients were 195 (8.3%), 9397 (38.9%), 10224 (42.3%), and 2539 (10.5%), respectively. The 5-year OS rate was highest in the young (42.1%), followed by middle-aged (34.8%), older (28.3%), and the oldest old patients (11.8%). Multivariable Cox regression analysis showed that middle-aged (aHR, 1.18; 95% CI, 1.10–1.27), older (aHR, 1.42; 95% CI, 1.32–1.52), and the oldest old patients (aHR, 2.15; 95% CI, 1.98–2.33) had worse OS than young patients. Consistently, middle-aged (aHR, 1.16; 95% CI, 1.08–1.25), older (aHR, 1.32; 95% CI, 1.23–1.43), and the oldest old patients (aHR, 1.86; 95% CI, 1.71–2.03) had worse BCSS than young patients.

Conclusion

This study provided clear evidence that de novo metastatic breast cancer had an age-specific pattern. Age was an independent risk factor for mortality in patients with de novo metastatic breast cancer.
Genetic variations underlying Gilbert syndrome and HBV infection outcomes: a cross-sectional study
Authors: Yao Bilian , Xu Qi , Zhang Xinxin , Han Yue
Published: November 2023

Background: Constant cellular damage causes a poor prognosis of hepatitis B virus (HBV) infection. Accumulating evidence indicates the cytoprotective properties of bilirubin. Here, we investigated the association of UDP glucuronosyltransferase family 1 member A1 (UGT1A1), the genetic cause of Gilbert syndrome (GS), a common condition of mild unconjugated bilirubinemia, with HBV infection outcomes.

Methods: Patients (n = 2,792) with unconjugated hyperbilirubinemia were screened for HBV infection and host UGT1A1 variations in Ruijin Hospital from January 2015 to May 2023, and those with confirmed HBV exposure were included. The promoter/exons/adjacent intronic regions of UGT1A1 were sequenced. HBV infection outcomes were compared between hosts with wild-type and variant-type UGT1A1. The effect magnitudes of UGT1A1 variations were evaluated using three classification approaches.

Results: In total, 175 patients with confirmed HBV exposure were recruited for final analysis. Age, gender, level of HBV serological markers, and antiviral treatment were comparable between UGT1A1 wild-type and disease-causing variation groups. Five known disease-causing mutations (UGT1A1*28, UGT1A1*6, UGT1A1*27, UGT1A1*63, and UGT1A1*7) were detected. The incidence of cirrhosis or hepatocellular carcinoma (LC/HCC) was significantly lower in UGT1A1 variant hosts than in UGT1A1 wild-type hosts (13.14% vs. 78.95%, p < 0.0001). The rarer the UGT1A1 variation a patient possessed, the higher the age at which LC/HCC was diagnosed (R = 0.34, p < 0.05). In contrast, patients without cirrhosis achieving HBsAg clearance were identified only in the UGT1A1 variant group (12.32% vs. 0%).

Conclusion: The findings of this study provide insights into the association between preexisting genetically mild bilirubin elevation and viral infection outcome. We showed that the accumulation of UGT1A1 variants or the rarity of the variation is associated with a better prognosis, and the effect magnitude correlates with UGT1A1 deficiency. This study demonstrates the therapeutic potential of host UGT1A1 variations underlying GS against HBV infection outcomes.
Feasibility of apalutamide combined with androgen deprivation therapy and short-course low-dose prednisone in treating metastatic hormone-sensitive prostate cancer: a pilot randomized controlled trial
Authors: Yang Dingyuan , Chen Wenqiang , Lai Fei , Qiu Mingxing , Li Jun
Published: November 2023

Introduction

The role of prednisone in the prevention of androgen receptor antagonist-related rash and treatment for metastatic hormone-sensitive prostate cancer (mHSPC) is unclear. This pilot trial (ChiCTR2200060388) aimed to investigate the feasibility of apalutamide combined with androgen deprivation therapy (ADT) and short-course low-dose prednisone in the treatment of mHSPC.

Methods

All patients received apalutamide and ADT and were randomly divided into two groups based on the administration of oral prednisone or not (control group). The primary endpoint was the incidence of rash. The secondary endpoint included the proportions of patients with a decline in PSA ≥50% from baseline, PSA ≥90% from baseline, and decreased to PSA ≤0.2 ng/mL.

Results

Between June 2021 and March 2022, a total of 83 patients were enrolled (41 in the prednisone group and 42 in the control group). During the 6-month follow-up, the incidence of rash was significantly lower in the prednisone group compared with the control group (17.1% vs. 38.1%, P=0.049). There were no significant differences in the incidence of other adverse events, the number of patients who required dose adjustment (reduction, interruption, or discontinuation) of apalutamide due to rash, the number of patients with prostate-specific antigen (PSA) decreased by ≥50%, the number of patients with PSA decrease ≥90%, and the number of patients with PSA ≤0.2 ng/mL between the two groups. All patients with diabetes had stable glycemic control with no glucose-related adverse events.

Discussion

In patients with mHSPC, the addition of short-course low-dose prednisolone to apalutamide plus ADT can reduce the incidence of rash without risk of other adverse events.
Healthy helpers: using culinary lessons to improve children’s culinary literacy and self-efficacy to cook
Authors: Policastro Peggy , Brown Alison H. , Comollo Erin
Published: November 2023

Background

Children do not eat the recommended amounts of vegetables, and school-based nutrition education has not been found to impact this behavior. Cooking education is associated with improved children’s culinary literacy (CL) and eating behaviors. This study investigated the impact of a culinary literacy (CL) curriculum on children’s acceptance of vegetable-added (mushrooms) recipes, CL, self-efficacy to cook (SE), and willingness to try vegetables (WV).

Methods

A convenience sample of 39 fourth and fifth graders were exposed to a six-lesson virtual CL curriculum that taught basic cooking skills and how to prepare six recipes, including three traditional recipes and the same recipes with added vegetables.

Results

Children who participated in the CL curriculum accepted vegetables added to pizza pockets, but vegetables added to macaroni and cheese and fajitas negatively affected the acceptance of recipes. Children improved their CL and SE but did not show a significant change in their WV.

Conclusion

Findings suggest that CL programs focusing on vegetables may drive factors associated with dietary behavior change, SE, and acceptance of vegetables. Future studies should consider CL as a potential method to improve vegetable intake in children in tandem with nutrition education or as a sole intervention. The study was limited by its small sample size, the virtual setting, and the use of mushrooms as the primary vegetable source. Future studies should be conducted with a larger sample size, in a traditional classroom setting, use a variety of vegetables, and collect qualitative data on the sensory characteristics affecting children’s WV.
Early life programming by diet can play a role in risk reduction of otitis in dogs
Authors: Hemida Manal B. M. , Vuori Kristiina A. , Borgström Nona C. , Moore Robin , Rosendahl Sarah , Anturaniemi Johanna , Estrela-Lima Alessandra , Hielm-Björkman Anna
Published: November 2023

Introduction

Otitis in dogs is often chronic while local treatment primarily consists of flushing, antibiotics, and/or antifungals. We were interested in finding early life variables that associate with otitis later in life, preferably some that could be modified.

Methods

A cross-sectional hypothesis-driven study with longitudinal data was performed to search for associations between pre- and postnatal exposures, and the incidence of owner-reported otitis in dogs at over 1 year of age. The multivariate logistic regression analysis study included data from 3,064 dogs and explored 26 different early life variables at four early life stages: prenatal, neonatal, postnatal, and puppyhood. We compared two feeding patterns, a non-processed meat-based diet (NPMD, raw) and an ultra-processed carbohydrate-based diet (UPCD, dry).

Results

We report that eating a NPMD diet significantly decreased the risk of otitis later in life, while eating a UPCD diet significantly increased the risk. This was seen in different life stages of mother or puppy: The maternal diet during pregnancy (p=0.011) and the puppies’ diet from 2 to 6 months of age (p=0.019) were both significantly associated with otitis incidence later in life, whereas the puppies’ first solid diet, was associated in the same way, but did not reach significance (p=0.072). Also, analyzing food ratios showed that when puppies were consuming >25% of their food as NPMD it significantly decreased their incidence of otitis later in life, while a ratio of >75% UPCD in their diet significantly increased their risk of otitis. Also, if the dog was born in the current family, was exposed to sunlight for more than 1 hour daily, and was raised on a dirt floor during puppyhood, there was a lower risk of otitis development later in life.

Discussion

The findings only suggest causality, and further studies are required. However, we propose that veterinarians, breeders, and owners can impact otitis risk by modifying factors such as diet and environment.
Prediksi Harga pada Trading Forex Pair USDCHF Menggunakan Regresi Linear
Authors: Edi Mohammad , Utami Ema , Yaqin Ainul
Published: November 2023

In the era of globalization, free trade grows rapidly and technology develops, affecting economic competition. Forex, foreign exchange trading, is one of the investments used to face this challenge. Technical and fundamental analysis is used to predict price movements in forex trading. Previous studies have used linear regression algorithms and other techniques for price prediction in forex. In this study, the linear regression algorithm is used to predict closing prices in forex trading because the linear regression algorithm is an algorithm that has been widely used in predictions, its strengths are in estimating simple model parameters and data based on time series. In addition, the linear regression algorithm can perform analysis using several independent variables so that the prediction results can be more accurate. The purpose of this study is to create a forex price prediction model, to make it easier for traders to make price predictions. A dataset of 2066 data was obtained through the metatrader software and processed through the preprocessing stage. The linear regression model was created using 5 scenarios, and the evaluation was carried out using the Mean Squared Error (MSE) and Root Mean Square Error (RMSE) values to select the best model. The results show that linear regression is able to predict the closing price of the USDCHF pair. The best linear regression model is obtained using the independent variable in scenario 1, namely the Open variable, with a linear regression equation of y=0.0145+0.9849x, the best MSE is 0.0000328509 and the best RMSE is 0.0057315705.
PENGARUH PENERAPAN SISTEM INFORMASI E-SAMSAT TERHADAP TINGKAT KEPATUHAN WAJIB PAJAK KENDARAAN BERMOTOR
Authors: Alghaviqi Muhammad Wafqi Aufa , Ishak Jouzar Farouq
Published: November 2023

Penelitian ini dilakukan untuk mengetahui pengaruh penerapan sistem informasi E-Samsat terhadap kepatuhan wajib pajak kendaraan bermotor di kantor SAMSAT Kabupaten Garut. Metode penelitian yang digunakan adalah deskriptif kuantitatif. Jumlah sampel yang digunakan dalam penelitian ini adalah 100 responden dengan beberapa kriteria. Data primer diperoleh melalui kuesioner. Dari hasil uji koefisien determinasi, penerapan sistem informasi E-Samsat memberikan pengaruh terhadap tingkat kepatuhan wajib pajak kendaraan bermotor sebesar 29,5%. Adapun dari hasil pengujian hipotesis terlihat nilai thitung sebesar 6,407 dan nilai ttabel sebesar 1,984. Hasil tersebut menunjukkan bahwa nilai thitung lebih besar dari nilai ttabel sehingga dapat disimpulkan bahwa H0 ditolak dan H1 diterima. Dengan demikian dapat disimpulkan bahwa terdapat pengaruh positif antara penerapan sistem informasi E-Samsat terhadap kepatuhan wajib pajak kendaraan bermotor di Kabupaten Garut.

Kata kunci: E-Samsat, Pajak Kendaraan Bermotor, Kepatuhan Wajib Pajak
Currency Fluctuations and Islamic Stock Indices in Emerging Markets
Authors: Mubarok Faizul
Published: November 2023

This research aims to explain why Islamic stock indexes tend to track the currency exchange rates of emerging countries. Granger causality is used in this analysis, and it is applied to daily data beginning with the day the index was first formed for each country. The Islamic stock indices of Malaysia, Indonesia, and India were employed as a research sample in this study. According to the findings of the research, there is only a correlation in one direction between the Islamic stock index and the currency exchange rate. Both the Islamic stock indexes in Malaysia and India have an effect on the currency exchange rate in that nation, whereas the currency exchange rate in India affects the Islamic stock index. This finding is helpful as a source of data in determining policies for the development of the Islamic financial system because it was discovered that.

Keywords: Islamic Stock; Granger Causality; Exchange Rates; Developing Country
Analysis of the Influence of Online Promotion, Product Packaging and Price on Purchasing Decisions with Price as a Moderating Variable
Authors: Firdaus* Edi , Hurriyati Ratih , Dirgantari Dwi Puspo , Murugesu Karina Devi
Published: November 2023

This study aims to find out how online promotions, product packaging and prices affect purchasing decisions for culinary products "Cau Nugget" and to determine the effect of price moderation on online promotions in determining purchasing decisions. This study used a quantitative method involving consumer Instagram followers 'Cau Nugget' as a population and a sample of 121 respondents. The results of the study found that, of the three existing factors, online promotions did not have a significant influence on purchasing decisions. Meanwhile, product packaging and price have a significant effect on purchasing decisions. This study proves that price negatively moderates online promotions on purchasing decisions, as well as being the indicator that has the highest impact on purchasing decisions.

Keywords: Online Promotion; Product Packaging; Price; Buying Decision; Home Industry
Digital Marketing Utilization Determinants: Study on MSEs in Salatiga City
Authors: Fevriera Sotya , Saraswati Birgitta Dian , Adhitya Dhian , Siwi Virgiana Nugransih , Wahyudi* Yustinus
Published: November 2023

This research aims to identify the factors influencing the use of digital marketing by Micro, Small, and Medium Enterprises (MSMEs) and to examine the factors affecting the preference for digital marketing usage by MSMEs in the city of Salatiga. The research sample consists of 135 business units representing MSMEs in Salatiga. Data analysis techniques involve descriptive statistical analysis, qualitative analysis, binomial and multinomial logistic regression. The research findings provide evidence of the implementation of the UTAUT theory, particularly concerning performance expectations and facilitating conditions, significantly influencing the probability of digital marketing usage and the marketing of business products. Surprisingly, acceptance as part of performance expectations has a negative impact on digital marketing usage, especially on social media platforms. Furthermore, digital marketing proves to be of paramount importance for MSMEs looking to expand their businesses.

Keywords: MSMEs; Digital Marketing; Covid-19; UTAUT Theory; Logistic Regression
Enhancing User Satisfaction with Local Government E-Government: The Influence of E-Government Quality (E-GovQual)
Authors: Rachman* Adryan , Alvita Meilisa , Widjadja William
Published: November 2023

This research aims to enhance the accountability of user satisfaction measurement in E-Government within local government in Indonesia, with a focus on six knowledge aspects and their impact on E-Government services in West Java. The method employed is descriptive and verificative, utilizing a quantitative approach. The heads of sections in West Java local government organizations served as respondents in the survey. User satisfaction with local government E-Government is positively and significantly influenced by usefulness, dependency, trust, functionality and form of interaction, as well as support. The novelty of this research reveals that usability and trust are key factors in improving government websites. For the future, further exploration and diverse ideas are needed to better understand this topic, and attention should be given to user responses and behaviors when using government websites for further improvement.Keywords: User Satisfaction; Quality of E-Government; Ease of Use;  Function of Interaction; Content of Information
Implementasi Aplikasi Steganografi Berbasis Web Menggunakan Algoritma LSB dan BPCS
Authors: Adhimah Laily Farkhah , Nurhafiyah Isti , Muntahar Adnan Aditya , Kristiaji Fandi , Mustofa Dinar
Published: November 2023

Steganography is a method for concealing sensitive information in seemingly unremarkable data. In recent years, the use of steganography in web applications has become popular due to its accessibility and ability to conceal data in various types of media. Implementing a web-based steganography program that makes use of the Bit-Plane Complexity and Least Significant Bit algorithms is the aim of this project. To enable users to access the application through a browser, the system is constructed utilizing web technologies like HTML, CSS, and JavaScript during the design phase. The LSB and BPCS algorithms are employed as methods to embed secret data into user-selected images. The least significant bit of each image pixel is utilized to hold a secret piece of information using the straightforward steganography technique known as LSB. On the other hand, BPCS is a more complex steganography method that combines spatial and frequency domain analysis to hide data within high-quality images. The findings of this study show that the technique of hiding sensitive information within photos is successfully implemented by the web-based steganography program employing the LSB and BPCS algorithms.
Perbandingan Algoritma Sobel dan Canny untuk Deteksi Tepi Citra Daun Lidah Buaya
Authors: Maximillian Louis , Riti Yosefina Finsensia , Agung Mario Anugraha , Palis Yohanes Junardi
Published: November 2023

Penyakit daun yang umum terjadi pada tanaman lidah buaya, seperti busuk daun, busuk akar, infeksi bakteri, dan serangan virus, dapat menimbulkan kerusakan yang cukup parah. Identifikasi penyakit-penyakit tersebut masih mengandalkan pengalaman petani dan seringkali menimbulkan interpretasi yang salah. Solusi modern telah ditemukan melalui penerapan teknologi informasi, khususnya di bidang pengolahan citra digital. Dengan menggunakan metode ini, diagnosis penyakit pada daun lidah buaya dapat ditingkatkan melalui deteksi tepi objek pada gambar daun. Hasil deteksi tepi ini memungkinkan mengidentifikasi gejala penyakit dengan lebih akurat. Dalam konteks ini, algoritma Canny dan Sobel, dua algoritma yang umum digunakan untuk deteksi tepi pada gambar, terbukti menjadi pilihan yang efektif. Dengan menggunakan metode tersebut, gambar tepi daun lidah buaya dapat diidentifikasi secara akurat. Ini adalah langkah penting dalam mendukung petani dalam diagnosis dini penyakit dan mengambil tindakan tepat waktu untuk mengatasi masalah ini. Penelitian ini bertujuan untuk mendapatkan algoritma terbaik pendeteksian tepi daun lidah buaya berdasarkan nilai Mean Squared Error (MSE) dan Peak Signal-to-Noise Ratio (PSNR). Hasil pengujian menunjukkan bahwa algoritma Sobel memberikan hasil yang lebih baik dengan rata-rata pengukuran MSE sebesar 2781.88 dan rata-rata PSNR sebesar 14.04, sedangkan algoritma Canny memiliki rata-rata MSE sebesar 3542.02 dan rata-rata PSNR sebesar 12.92.
Tindakan Kompres Hangat Air Jahe Pada Klien Gout Arthritis Untuk Menurunkan Nyeri Di Yayasan Pondok Lansia Tulis Kasih
Authors: Kartika Yulia , Meilianingsih Lia , Supriadi Supriadi
Published: November 2023

Lanjut usia (lansia) adalah seseorang yang mencapai usia berumur >60 tahun. Lansia mengalami berbagai penurunan di fisiknya terutama  sering mengeluh terjadinya nyeri di persendian akibat gout arthritis. Gout arthritis merupakan penyakit yang menyerang sendi akibat tingginya kadar asam urat dalam darah sehingga menyebabkan nyeri yang berulang pada daerah persendian terutama bagian lutut. Salah satu tindakan untuk mengatasi nyeri tersebut adalah dengan melakukan kompres hangat air jahe. Rancangan dalam studi kasus ini yaitu menggunakan studi kasus deskriptif yang bertujuan untuk menggambarkan pemberian tindakan kompres hangat air jahe untuk menurunkan nyeri pada klien lansia dengan gout arthritis. Pengumpulan data melalui penilaian nyeri, observasi, wawancara, dan pemeriksaan fisik pada dua klien lansia. Pelaksanaan tindakan dilakukan dari tanggal 14-20 Maret 2022 di Yayasan Pondok Lansia Tulus Kasih selama 20 menit dengan frekuensi 1 kali tindakan pada pagi hari. Hasil studi kasus ini menunjukkan kedua klien sebelum diberikan tindakan kompres hangat air jahe mengeluh nyeri dengan skala nyeri 5 atau dalam kategori nyeri sedang dan setelah diberikan kompres hangat selama 7 hari terjadi penurunan skala nyeri menjadi skala 0 yang berarti tidak nyeri pada klien 1 dan skala 1 yang berarti nyeri ringan pada klien 2. Diharapkan studi kasus dapat menjadi pedoman untuk mengatasi masalah nyeri pada lansia akibat gout arthritis terutama di panti dan dapat dilaksanakan oleh lansia maupun petugas panti secara mandiri.
PENGARUH WAKTU PENGAMBILAN DAN LAMA PENYIMPANAN SALIVA PADA SUHU REFRIGERATOR TERHADAP TITER STATUS SEKRETOR
Authors: Utami Putri Tiara , Noviar Ganjar , Hayati Eem , Nurhayati Betty
Published: November 2023

Sekretor adalah seseorang yang dapat mensekresikan antigen golongan darahnya ke dalam cairan tubuhnya seperti saliva. Saliva mengandung glikoprotein musin yang membawa spesifitas golongan darah. Saliva dapat terpengaruh oleh waktu pengambilan, suhu, dan lama penyimpanan. Pada penelitian ini dilakukan pemeriksaan titer status sekretor saliva pagi dan saliva sore yang disimpan pada suhu refrigerator (2-80C) selama 30 menit, 60 menit, dan 90 menit. Tujuan penelitian ini yaitu untuk mengetahui gambaran titer status sekretor dan melihat adakah pengaruh waktu pengambilan dan lama penyimpanan saliva pada suhu refrigerator terhadap titer status sekretor. Penelitian ini menggunakan 6 sampel saliva berstatus sekretor golongan darah A dengan metode aglutinasi inhibisi. Hasil penelitian ini yaitu saliva pagi dengan variasi lama penyimpanan menunjukkan rentang nilai titer status sekretor 1/16 - ≥1/512, sedangkan pada sampel saliva sore menunjukkan rentang nilai titer 1/8 - 1/256. Hasil uji statistik Friedman dan uji Wilcoxon terhadap waktu pengambilan saliva didapatkan nilai p (sig) 0,001 yang berarti nilai p (sig) < 0,05, artinya terdapat pengaruh waktu pengambilan saliva terhadap titer status sekretor. Sedangkan hasil uji Friedman dan uji Wilcoxon terhadap lama penyimpanan saliva pada suhu refrigerator (2-80C) didapatkan nilai p (sig) 0,027 yang berarti nilai p (sig) < 0,05 pada kelompok data saliva yang disimpan 90 menit, artinya terdapat pengaruh lama penyimpanan saliva terhadap titer status sekretor.
PERBANDINGAN KADAR UREUM PADA SERUM LIPEMIK METODE BERTHELOT DENGAN ULTRAVIOLET KINETIK
Authors: Lianti Desy , Riyani Ani , Nurhayati Dewi , Kurnaeni Nani
Published: November 2023

Serum lipemik dapat mengganggu pemeriksaan kadar ureum karena kekeruhan dalam sampel mempengaruhi pemeriksaan yang menggunakan spektofotometri. Pemeriksaan kadar ureum di laboratorium umumnya menggunakan pendekatan berdasarkan reaksi enzimatik dengan metode Berthelot atau UV kinetik. Metode dengan panjang gelombang rendah lebih banyak terpengaruh oleh serum lipemik, karena absorbansinya tinggi. Interferensi lipemia dalam metode spektrofotometri ditentukan oleh panjang gelombang reaksi dan arah reaksi (yang mengukur peningkatan atau penurunan absorbansi). Oleh karena itu, terdapat kemungkinan bahwa arah dan tingkat interferensi akan berbeda ketika membandingkan metode pemeriksaan yang berbeda untuk parameter yang sama.  Penelitian ini dilakukan di Laboratorium Kimia Klinik Jurusan Teknologi Laboratorium Medis Politeknik Kesehatan Kemenkes Bandung pada bulan Mei 2023. Jenis penelitian yang digunakan adalah quasi eksperiment (eksperimen semu) dengan desain penelitian static group comparation, yaitu dilakukan perlakuan terhadap kelompok eksperimen. Sampel yang digunakan dalam penelitian adalah pooled sera. Data diolah menggunakan uji statistik General Linear Model (GLM) dan Paired Sample T-Test, didapatkan hasil rata-rata kadar ureum pada serum lipemik dengan metode Berthelot secara berurutan berdasarkan kadar trigliserida 99,2; 378; 658 dan 932 mg/dL adalah 16,5; 19,3; 22,0; 24,3 mg/dL dan untuk metode UV kinetik adalah 21,6; 14,7; 8,58; 5,22 mg/dL. Hasil data pada kedua metode ureum memiliki nilai p 0,001 < Sig 0,05. Dari hasil tersebut dapat disimpulkan bahwa terdapat perbedaan yang signifikan antara metode Berthelot dan UV kinetik.
PERBANDINGAN KUALITAS HASIL PREPARAT HISTOLOGI JARINGAN GINJAL DENGAN FIKSASI MENGGUNAKAN NEUTRAL BUFFER FORMALIN 10% DAN ETANOL 50%
Authors: Salsabila Qatrunnada , Durachim Adang , Wiryanti Wiwin , Rahmat Mamat
Published: November 2023

Fiksasi merupakan tahapan pertama yang dilakukan pada pembuatan preparat histologi yang tujuannya adalah untuk mengawetkan struktur dan unsur-unsur jaringan agar dalam keadaan yang sama dengan keadaan asli jaringan. Larutan untuk fiksasi yang biasa digunakan adalah Neutral Buffer Formalin 10%. Etanol 50% memiliki kandungan Formaldehide yang memiliki kemampuan untuk mengawetkan jaringan. Penelitian ini bertujuan ialah mengetahui apakah larutan fiksatif Etanol 50% dapat digunakan untuk memfiksasi jaringan ginjal. Sampel pada penelitian ini adalah ginjal mencit yang dibuat menjadi 20 sediaan preparat, yang berasal dari 10 jaringan ginjal difiksasi menggunakan Neutral Buffer Formalin 10% sebagai kontrol dan 10 jaringan ginjal yang difiksasi menggunakan Etanol 50% sebagai pembanding yang sama-sama difiksasi selama 24 jam. Parameter penelitian ini diantaranya pengukuran penyusutan pada jaringan sebelum dan sesudah difiksasi, artefak dan purification yang disebabkan oleh proses fiksasi jaringan. Uji stsatistik yang digunakan yaitu Kruskall Wallis jika data yang distribusinya normal dan uji Mann Whitney apabila data tidak terdistribusi secara normal. Distribusi data pada pengamatan penyusutan jaringan dan artefak tidak normal. Berdasarkan hasil nilai uji Mann Whitney, didapatkan nilai Asymp Sig. (2-tailed) yaitu 1.000 yang mana keduanya bernilai >0,05 artinya tidak terdapat perbedaan yang bermakna antara penggunaan Neutral Buffer Formalin 10% dan Etanol 50% sebagai larutan fiksasi jaringan ginjal.
PENGARUH WAKTU SIMPAN DARAH DAN JENIS TABUNG TERHADAP NILAI TROMBOSIT
Authors: Hayati Eem , Thirafi Fakhrana Yusup Nurin , Durachim Adang , Noviar Ganjar
Published: November 2023

Pemeriksaan hitung sel darah, salah satunya parameter trombosit, merupakan pemeriksaan yang sering dilakukan di laboratorium klinik karena memiliki peranan penting, karena berbagai faktor seringkali terjadi penundaan pada proses pemeriksaan. Namun berdasarkan PERMENKES No.43 Tahun 2013 stabilitas  trombosit pada suhu kamar tidak boleh lebih dari 2 jam. Dalam proses pemeriksaan tentu tidak dapat dipungkiri pentingnya penggunaan tabung sebagai wadah penampung darah. Selama 50 tahun terakhir, tabung kaca telah menjadi perangkat standar untuk pengujian laboratorium klinis. Seiring perkembangan zaman kepedulian terhadap keselamatan pegawai laboratorium dan pembuangan limbah biologis telah mengarah pada pengembangan tabung plastik. Bahan penelitian ini  yakni whole blood EDTA sebanyak 4.5mL dengan variasi lama simpan darah 0 jam, 5 jam ,dan 6 jam, kemudian dilakukan pemeriksaan parameter jumlah trombosit. Tujuan penelitian ini adalah untuk melihat pengaruh tabung kaca dan tabung plastik dengan variasi penyimpananterhadap jumlah trombosit. Jenis penelitianyang digunakan adalah eksperimen semu. Data diolah menggunakan uji General Linear Model untuk data yang berdistribusi normal, apabila semua atau salah satu variabel data tidak berdistribusi normal maka dilanjutkan dengan Uji Friedman dan Wilcoxon. Hasil pemeriksaan dengan Micro tube berbahan plastik relatif lebih rendah dibandingkan Vacutainer tube berbahan kaca. Secara statistik didapatkan nilai sig >0.05 sehingga diketahui tidak terdapat perbedaan yang signifikan pada  Vacutainer tube K3EDTA dan Micro tube K3EDTA. Sedangkan pada waktu simpan darah 5 jam dan 6 jam terdapat perbedaan dengan nilai sig < 0.05. Dapat disimpulan tidak terdapat perbedaan yang bermakna secara statistic, namun terdapat pengaruh secara klinis pada penundaan darah 6 jam dikedua jenis tabung terhadap nilai trombosit.
POLA KEPEKAAN ISOLAT BAKTERI KULTUR PUS PADA INFEKSI KULIT DAN JARINGAN LUNAK TERHADAP BERBAGAI ANTIBIOTIKA
Authors: Kurniati Iis , Nur Inayah Risma , Dermawan Asep , Wahyuni Yeni
Published: November 2023

Infeksi kulit dan jaringan lunak adalah infeksi yang umum di Indonesia karena keadaan udara di Indonesia yang lembab dan berdebu, sehingga bakteri dapat dengan mudah tumbuh subur. Kondisi ini didukung dengan keadaan kebersihan yang buruk sehingga mempermudah berkembang biaknya penyakit infeksi. Upaya untuk membantu pemerintah mengurangi resistensi antibiotika yaitu dengan memberikan antibiotika berdasarkan hasil pola bakteri dan uji kepekaan bakteri terhadap antibiotika. Penelitian ini bertujuan untuk mengidentifikasi pola kepekaan isolat bakteri kultur pus pada infeksi kulit dan jaringan lunak terhadap berbagai antibiotika. Penelitian ini menggunakan metode deskriptif sedangkan desain penelitian ini adalah observasional analitik. Dari hasil penelitian bakteri yang ditemukan terbanyak adalah Staphylococcus aureus (29.7%), Streptococcus pyogenes (12.2 %), Escherichia coli (10.8%), Klebsiella pneumoniae ssp pneumoniae (9.5%), Enterococcus faecalis (8.1%), Citrobacter freundii (5.4%), Streptococcus agalactiae (5.4%), Klebsiella oxytoca (4.1%), Pseudomonas aeruginosa (4.1%), Morganella morganii (2.7%), Proteus mirabilis (2.7%), Acinetobacter sp (1.4%), Proteus ssp (1.4%), Staphylococcus epidermidis (1.4%), Streptococcus dysgalactiae (1.4%). Sebagian besar Gram negatif resisten diatas 50% terhadap ampicillin dan sensitif 100% terhadap amikacin, sedangkan sebagian besar Gram positif resisten diatas 50% terhadap oxacillin, dan tetracycline, sensitif 100% terhadap ampicillin, linezolid, tigecycline, ceftriaxone, thrimethoprim supfamethoxazole.
Production of the Scaffold Using 3D Bioprinting Applied to the Biomedical Area: A Bibliometric Study
Authors: Ana Paula Bispo Gonçalves  , Willams Teles Barbosa  , Jaqueline Leite Vieira  , Josiane Dantas Viana Barbosa  , Milena Botelho Pereira Soares
Published: November 2023

Tissue Engineering is an ascent area with clinical applications through combining cells and biomaterials to reconstitute organs and tissues using scaffolds. These are defined as porous, temporary, biodegradable threedimensional supports used to mimic the structure of the extracellular matrix and stimulate specific cellular responses at the molecular level. Among the existing technologies for producing scaffolds, 3D bioprinting stands out as one of the most promising technologies that enable layer-by-layer deposition with precise control of the spatial arrangement of functional components. One of the most used biomaterials for the fabrication of scaffolds for application in Tissue Engineering is poly(lactic acid), PLA, a biodegradable, biocompatible, and non-toxic polyester, whose main application is in the regeneration and replacement of bone tissue. In this way, the present article aims to obtain a comprehensive view of the current scenario of PLA scaffolds obtained by 3D bioprinting for biomedical applications through bibliometric analysis. The research was conducted in the Web of Science database between August 16 and 17, 2022. The following set of keywords was used: "scaffolds" AND "PLA" AND "3D printing" AND "biomedical applications" OR "biomedical application," resulting in 2,351 publications in the last five years. The VOSviewer software was used as a bibliometric analysis tool to visualize country networksand keywords on the topic studied. Based on the results, it was possible to observe that China, India, and the USA are the countries that published the most on the subject, and Chinese institutions and authors are also responsible for a considerable part of the publication of documents. There was also an increase in publications in the last five years, reinforcing the research interest that strengthens Tissue Engineering.
O papel da família na clínica dos desvios/transtornos fonológicos: uma análise de pesquisas australianas
Authors: Schaskos Bruna , Vieira Sammia Klann , Berberian Ana Paula , Borges Carlos Eduardo
Published: November 2023

A literatura a respeito do envolvimento da família na terapia dos chamados desvios/transtornos fonológicos ainda é lacunosa. Entre as poucas pesquisas existentes, há um grupo de autores australianos que vem produzindo, desde a década de 90, uma reflexão a esse respeito. O objetivo desse estudo é apresentar as propostas desses autores e analisá-las de maneira crítica, especialmente no que diz respeito ao papel que eles conferem à família na terapia e quanto às perspectivas teóricas que fundamentam sua prática. Como princípio metodológico foram selecionados artigos produzidos em universidades australianas que tematizam o papel da família nos chamados desvios/transtornos fonológicos, e, em seguida, foi realizada uma análise crítica desses artigos enfocando as concepções de família e de aquisição de linguagem que os fundamentam. Entre os resultados destaca-se o fato de que os textos apresentam uma abordagem parecida com relação à participação dos familiares, envolvendo orientação e treinamento dos pais, que oferecem a eles técnicas de modificação comportamental. Os textos não deixam explícito quais as concepções de aquisição de linguagem e de família que os fundamentam. No entanto, presume-se que a argumentação e alguns termos utilizados na escrita indiciem a fundamentação empregada. Apesar de serem mencionados trabalhos interacionistas e cognitivistas, o emprego recorrente de expressões como “modelos de linguagem”, “feedback”, “treinamento”, “modificação de comportamento”, “registros”, “reforçamento”, nos permite concluir que esses trabalhos são predominantemente fundamentados no behaviorismo.
THE INFLUENCE OF CLASSIC MUSIC T PENGARUH PEMBERIAN TERAPI MUSIK KLASIK TERHADAP PENURUNAN TINGKAT KECEMASAN PADA IBU BERSALIN DI KLINIK ROMAULI MARELAN TAHUN 2023
Authors: Syafitri Endryani , Mardha Muthia Sari , Simatupang Friska Yuni
Published: November 2023

Introduction: Labor and birth are physiological things that almost every woman will experience. However, even though this is a physiological thing, it will make the mother feel anxious because during the labor process she will experience excruciating pain, pain during labor can reduce the uterus' ability to experience contractions, thereby lengthening the time during the labor process. The discomfort experienced by someone who is about to give birth will increase and can cause anxiety. Objective to determine the characteristics of respondents (based on age, education, occupation, parity), to determine the level of anxiety, to determine the effect of providing classical music therapy on reducing maternal anxiety levels before and after being given classical music therapy. birth at the Romauli Marelan Clinic in 2023. The research design used in this study was a quasi-experimental design with a one group type pretest and posttest design. Results: From research that obtained the level of maternal anxiety before treatment, the normality test results were 0.178 > 0.05, which means the data was not normally distributed, then the Wilcoxon test was carried out and obtained a significant value of P=0.000 where p<0.05, "there is an effect of therapy classical music on reducing anxiety levels in mothers giving birth. there is an influence of classical music in reducing anxiety levels in mothers giving birth. Music therapy can help mothers relax and provide early stimulation to the fetus, so it is recommended as an effective intervention for mothers in labor.
the EFFECT OF PURPLE SWEET POTATO (Ipomea Batatas L. Poir) ON INCREASING HBW IN PREGNANT WOMEN AT ROMAULI CLINIC
Authors: Mardha Muthia Sari , Syafitri Endriyani , Lestari Maya
Published: November 2023

The number of anemia in pregnant women in Indonesia based on Riskesdas data has increased compared to 2013, in 2013 there were 37.1% of pregnant women with anemia while in 2018 it increased to 48.9%. This study aims to determine the effect of purple sweet potato stew on increasing Hb in pregnant women. This study used a one group pretest and posttest research design. The population in this study were all pregnant women who came to visit the clinic during April, samples were taken by accidental sampling. The analysis in this study used the Wilcoxon test. The results of this study showed that the results of the normality test were 0.000 <0.05, this means that the data was not normally distributed, and the Wilcoxon test was carried out to obtain p = 0.025, which means p = <0.05. It can be concluded that there is an effect of giving purple sweet potato stew on Increased HB levels in pregnant women. The conclusion in this study is that there is an effect of purple sweet potato stew on increasing HB levels in pregnant women. It is hoped that the results of this study will be used as material for evaluation and policy reference for health workers to apply purple sweet potato decoction to increase Hb in pregnant women to prevent anemia.

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HUBUNGAN PENGETAHUAN, JARAK POSYANDU, DAN SUMBER INFORMASI DENGAN MINATNYA REMAJA KE POSYANDU DI WILAYAH KERJA UPTD PUSKESMAS PENYANDINGAN
Authors: Fitria Grama Depa  , Murdiningsih  , Putu Lusita Nati Indriani
Published: November 2023

Adolescent posyandu is one form of Community Resource Health Effort (UKBM) which is managed and organized from, by, for and with the entire community including adolescents in empowering the community and providing convenience in obtaining health services for adolescents to improve the degree of health and healthy life skills of adolescents. T This type of research is observational research that is analytical in nature with a cross sectional design or approach. The sample in this study was adolescents aged 12 years to 18 years with a sample of 75 respondents. The type of data uses primary data, The results of bivariate research on the relationship between Knowledge, Posyandu Distance, and Information Sources with Adolescents' Interest in Posyandu based on the chi square statistical test of p-value knowledge 0.021 < 0.05, posyandu distance p-value 0.021 <0.05 and p-value information sources 0.027< 0.05 can be concluded that there is a relationship between knowledge, posyandu distance, and information sources simultaneously with adolescent interest in going to posyandu in the UPTD work area of the Ogan Komering Ulu Regency Pairing Health Center in 2023. The advice to the leadership of UPTD Puskesmas Penyandingan is to increase information about the Youth Posyandu by involving community leaders, health workers to provide counseling and counseling, as well as distributing brochures, billboards, and advertisements in print and electronic media so that the public knows the importance of the Youth Posyandu
HUBUNGAN PENGETAHUAN, DUKUNGAN KELUARGA DAN DUKUNGAN PETUGAS KESEHATAN DENGAN KEPATUHAN IBU HAMIL MENGKONSUMSI TABLET FE DI PUSKESMAS LUBUK BATANG
Authors: Karima Yeyen Warizqin , Suprida Suprida , Anggraini Arie , Mastina Mastina
Published: November 2023

Compliance with consuming Fe tablets is said  if pregnant women consume all of the Fe tablets given during pregnancy. Adherence of pregnant women consuming Fe tablets is an important factor in ensuring an increase in hemoglobin levels of pregnant women. This type of research was an analytic observational study with a cross-sectional approach or design. sectional. The population in this study amounted to 103 people and the sample in this study were pregnant women at 36 weeks' gestation totaling 30 respondents. The results of bivariate research on the relationship between knowledge, family support and health worker support with adherence of pregnant women to consuming Fe tablets based on the chi square statistical test of knowledge p-value 0.007 <0.05 OR 13.500, family support p-value 0.024 <0.05 OR 11,000 and support Health workers p-value 0.007 < 0.05 OR 0.074 It can be concluded that there is a relationship between knowledge, family support and health worker support simultaneously with the compliance of pregnant women consuming Fe tablets in the working area of the UPTD Puskesmas Lubuk Batang, Ogan Komering Ulu Regency in 2023. Suggestions to respondents It is hoped that in this study pregnant women will get important information about pregnancy, especially regarding the need for Fe tablets during pregnancy and pregnant women are expected to consume Fe tablets together with vitamin C so that the absorption of Fe tablets can be optimal.
Diagnoza i perspektywy przemian w cywilizacji zachodniej
Authors: Wadowski Jan
Published: November 2023

Celem artykułu jest próba uchwycenia różnic oraz podobieństw odnoszących się do cywilizacji zachodniej, które zawarte są w myśli francuskiej filozof politycznej Chantal Delsol oraz w eko-filozofii Henryka Skolimowskiego. Polski filozof na bazie radykalnej krytyki cywilizacji Zachodu zbudował własną koncepcję filozoficzną będącą swoistym remedium na współczesny kryzys. Chantal Delsol natomiast bardzo wnikliwie wypunktowała słabości i niedomagania cywilizacji Zachodu. W pierwszej części tekstu zaprezentowano koncepcje obojga badaczy. W drugiej i trzeciej części autor omawia podobieństwa i różnice pomiędzy sposobem postrzegania cywilizacji Zachodu przez analizowanych myślicieli, a także postulaty ewentualnych rozwiązań aktualnego kryzysu, który – w świetle tekstów obojga uczonych – ma przede wszystkim charakter duchowy i wywodzi się z braku ujęć o charakterze integralnym i empatycznym. W artykule podjęta została próba scharakteryzowania niektórych diagnoz i prognoz obojga wymienionych autorów, które dotyczą zarówno aktualnej sytuacji cywilizacji Zachodu, jak i jej przyszłości. W artykule zastosowano metodę porównawczą oraz metodę analizy krytycznej.
Idea postępu w piśmiennictwie Józefa Ordęgi (1802–1879)
Authors: Miernik Karol
Published: November 2023

Józef Ordęga (1802–1879) był polskim szlachcicem, uczestnikiem powstania listopadowego, a następnie jednym z działaczy Wielkiej Emigracji we Francji. W niniejszym artykule podjąłem próbę refleksji nad znaczeniem, jakie idea postępu zajmowała w jego piśmiennictwie z lat 1838–1846, kiedy próbował samodzielnej działalności politycznej. Wskazałem na silną inspirację doktryną francuskiego socjalizmu utopijnego, w szczególności saintsimonisty Philippe’a Bucheza. Ordęga, w ślad za nim, uważał, że postęp polega na wypełnianiu przez ludzkość celów objawianych stopniowo przez Boga. Twierdził, że idee związane z rewolucją francuską (wolność, równość, braterstwo) są realizacją nauki Chrystusa i mają z gruntu katolicki charakter. Ponadto w ogólnym procesie postępu przypisywał szczególną rolę Polsce, wyrażając nadzieję, że w przyszłości odrodzi się ona jako państwo w pełni demokratyczne.
Wstęp
Authors: Smołucha Janusz
Published: November 2023

W kolejnym tomie „Rocznika Filozoficznego Ignatianum” kilka pierwszych tekstów poświęconych zostało roli i znaczeniu architektury w kulturze. Od najdawniejszych czasów była ona środkiem wyrażania harmonii, proporcji i ludzkiego intelektu. Zarówno w dobie antyku, jak i w średniowieczu zadaniem architektury było odzwierciedlenie zasad równowagi i symetrii otaczającego świata. W dobie renesansu architektura przestała być klasyfikowana jako dziedzina wyłącznie techniczna i zaczęto ją postrzegać również w kontekście humanistycznym. Zauważono bowiem, że odpowiada ona nie tylko za prawidłową konstrukcję budynków, ale poprzez wykorzystywanie symboli i estetyki wywiera duży wpływ na kulturę i społeczeństwo. Zarówno budowle – świątynie, szkoły, siedziby władzy, jak i zwykłe mieszkania – były projektowane w taki sposób, aby odzwierciedlać potrzeby społeczne danej epoki. Prostota i symetria w formach na przemian rywalizowały z ekstrawagancją, dynamiką, dramatyzmem. Poszukiwanie przyczyn tych zjawisk stanowi główną oś rozważań prezentowanych poniżej tekstów.