bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Supply Chain Strategy, Competitiveness, and Business Performance at Passion Fruit Processing Industry in Gowa Regency
Authors: Munizu Musran , Alam Syamsu , Pono Maat , Asdar Muhammad , Harmoko Arifin Andi
Published: March 2024

Passion fruit products are one of the superior products processed by the agribusiness sector industry in Gowa Regency. In order for the passion fruit processing industry to continue to exist and be sustainable in the market, understanding supply chain strategy, competitiveness and business performance is very important for managers/owners. This study aims to explain and analyse the important elements of supply chain strategy, daylight and business performance. This study uses a quantitative approach, where primary data is obtained from 105 managers or owners through questionnaires on April to July in 2023. Research data was processed and analysed using confirmatory factor analysis (CFA). The research results show that the main element forming a supply chain strategy is responsiveness. Product quality is a key element in shaping a company's competitiveness, and business performance is more dominantly determined or shaped by the company's sales growth. The implications of this study provide direction for managers of the passion fruit processing industry regarding the importance of responsiveness aspects in implementing supply chain strategies, product quality in developing competitiveness, and sales growth aspects to produce superior performance.
Existing Performance of Cocoa Agroindustry: Learn From Pt. Indonesia Hijau, Polewali Mandar, Indonesia
Authors: Natasya Kautsar Muthia , Arsyad Muhammad , Nixia Tenriawaru A.
Published: March 2024

PT. Indonesia Hijau carries out innovation in the form of a processing business made from fermented cocoa beans. Processing cocoa beans into several types of chocolate products creates added value and also sells buy order chocolate products. This research aims to analyze production performance and marketing mapping of processed chocolate products. The method used in this research is quantitative descriptive analysis. The results of the production performance of PT. Green Indonesia from the productivity aspect is categorized as good (>21,55 kg/HOK) and the capacity aspect is also categorized as good (>0.7). From the aspect of raw material and product quality, PT Indonesia Hijau has SNI, P-IRT, Halal and BPOM status. Apart from that, the flexibility aspect is considered to be good because it meets 3 dimensional measurements and also has a relatively good process speed aspect. However, this research suggests that the use of e-commerce in marketing can be optimized. Apart from that, you need to think about product delivery, which currently still takes a long time (because you have to transit first) in several cities, before arriving at the final destination city by means of the local government making a port of delivery of goods.
Study of the Social Impact of Environmental Management: Farmers Perceptions of Takalar Industrial Area Development Planning
Authors: Zulkarnaim Sumang Andi , Tahara Tasrifin , Demmallino Eymall B.
Published: March 2024

The establishment of the Takalar Integrated Industrial Park (KITA) is confirmed by Presidential Regulation no. 18 (2020), aligning with the 2020-2024 National Medium Term Development Plan, which outlines the development of 18 industrial areas. It is imperative that the development process synchronizes with human resource advancement to yield benefits for both the environment and the neighboring farming community. This study aims to gauge farmers' perspectives on the social aspects of managing their environment in light of industrial area development plans, focusing on demographic, socio-economic, and cultural factors. Employing a descriptive qualitative approach, the research conducted Focus Group Discussions (FGDs) involving six farmers and informants to assess their perceptions and expectations regarding KITA's development. Results indicate overall farmer approval of KITA's development, with a majority holding positive perceptions of the planning process. Demographically, farmers anticipate KITA's development as a primary avenue for increasing employment opportunities. They also foresee business prospects that could enhance their economic status, alongside anticipated improvements in infrastructure and the expected population growth. In terms of socio-cultural dynamics, concerns regarding potential clashes between local communities and newcomers are minimal, with farmers believing that cultural disparities will not disrupt traditional activities.
Development Strategy Analysis of Breadfruit Agribusiness in Bone Regency
Authors: Hatta Rachmi , Rukmana Didi , Rahmadanih  , Amiruddin Achmad
Published: March 2024

Breadfruit (Artocarpus altilis) has been recognized by Indonesian as an alternative food source that is rich in nutrients. The production of breadfruit in Bone Regency has shown a stable trend with a fairly consistent increase over the last five years. The purpose of this research is to analyze the development strategy of breadfruit Processing Agribusiness in Bone Regency. Analytical Hierarchy Process (AHP) method was applied to formulate the most effective strategies for breadfruit processing business development. The research was conducted by involving informants from various backgrounds such as processed breadfruit farmers in Bone Regency, breadfruit traders and businessmen from processing subsystem, government and agricultural extension workers. From the result of the analysis it can be identified that in order, efforts to increase the production and quality of breadfruit, development of marketing areas, optimization of natural resources, human resources, and existing equipment are important elements in the breadfruit development strategy in Bone Regency, South Sulawesi. increasing the production and quality of breadfruit holds the highest rank with a value of 0.1517 as a priority in encouraging stakeholders to innovate and optimize available market opportunities. By considering these factors, the government can form policies that support the sustainable growth of breadfruit agribusiness.
Institutional Role In Cocoa Supply Chain And Cocoa Added Value In Bulukumba District
Authors: Apriliani Rakhman Fira , Musran M. , Mahyuddin Mahyuddin
Published: March 2024

Supply chain institutions are management relationships or systematic working system and mutually supportive between several supply chain partnership of institutions. The aim of this study was to determine the role of institutions in the supply chain for cocoa commodities in Bulukumba Regency and to analyze the added value of each actor in the supply chain for cocoa commodities in Bulukumba Regency. The method of determining the sample was done by purposive sampling. Descriptive analysis and supply chain value added analysis were used as Institutional role data analysis using the hayami method. The results of the study showed that supply chain institutions had a role for the success of the cocoa supply chain. Analysis of added value of farmers was Rp. 29,029,000 with added value of the collector traders was Rp. 1,900/kg, wholesalers added value of Rp. 1,900/kg and the added value of the cocoa processing home industry was Rp. 32,500/kg. Therefore, all the institutions involved had their important roles for the success of the cocoa supply chain. The roles were cultivating, providing assistance, processing, buying and selling. The added value of the cocoa processing home industry was high (>50%), while the added value of wholesalers and collector trades low (>50%).
Delir - Symptome, Ursachen, Behandlung – Erkennen und Behandeln des akuten Verwirrtheitssyndroms
Authors: Filipovic Silke , Hermes Carsten
Published: March 2024

Ein Delir ist eine komplexe Störung und gleichzeitig eine ernsthafte Herausforderung. Nicht nur in der medizinischen und pflegerischen Versorgung ist es von entscheidender Bedeutung, ein Delir frühzeitig zu erkennen. Auch Physiotherapeut*innen können adäquate Maßnahmen ergreifen, um das Risiko von Komplikationen zu minimieren und den Genesungsprozess zu fördern.
Die Rechtsfrage: Sind zusätzliche Einwilligungen für Videoaufnahmen erforderlich?
Authors: Schlegel Thomas
Published: March 2024

Für die Dokumentation oder Befunderhebung des Gangbilds mittels Videoanalyse nutzen wir ein klinikeigenes Tablet. Trotzdem sollen alle Patient*innen für jede Videoaufnahme eine Einwilligungserklärung unterschreiben. Reicht der unterschriebene Behandlungsvertrag nicht aus, in dem solche digitalen Dokumentationen enthalten sind?

Therapeutin aus Baden-Württemberg
Tore schießen mit Rollator – Spielerisch zu Bewegung motivieren
Authors: Teetz Christiane
Published: March 2024

Luftballons, Marmeladendeckel, Eierkartons – mit Alltagsgegenständen bringt der Niederländer Joël Kruisselbrink alte Menschen in Bewegung und landet damit einen viralen Erfolg nach dem anderen. Auch viele Physios folgen seinen Social-Media-Accounts. Lesen Sie, was seine Methode von anderen unterscheidet und warum sie so gut funktioniert.
Mysteriöse Steifheit – Red Flags erkennen
Authors: Zalpour Christoff , von Piekartz Harry
Published: March 2024

Lena ist Landwirtin und kämpft seit Monaten mit krampfartigen Schulterschmerzen und einer Art Blockade beim Armheben. Im Laufe der Zeit stellt sie fest, dass es einen Zusammenhang mit ihren Verstopfungsbeschwerden gibt. Ein Hinweis, der ihren Therapeuten aufhorchen lässt.
IDH1, ATRX, p53, and Ki67 Expression in Glioblastoma patients: Their Clinical and Prognostic Significance—A Prospective Study
Authors: Meel Mukta , Jindal Arpita , Kumar Mukesh , Mathur Kusum , Singh Ashok
Published: March 2024

Context Glioblastoma multiforme (GBM) is a malignant and aggressive primary brain tumor with a poor prognosis. This adverse prognosis is due to the tumor's tendency for advancement and recurrence caused by highly intrusive nature of the persisting GBM cells that actively escape from the main tumor mass into the surrounding normal brain tissue. On the basis of biomarker illustration, it can be classified into molecular subgroups.

Aims (1) To determine the expression of IDH1, ATRX, p53, and Ki67 by immunohistochemistry, in a cohort of GBMs. (2) To determine whether altered protein expression of any of these growth-control genes in GBM will show association with patient survival. (3) To establish prognostically distinct molecular subgroups of GBM, irrespective of histopathological diagnosis.

Results In this prospective observational study, 35 histologically diagnosed cases of glioblastoma were enrolled. The mean age at the time of presentation was 43.46 ± 17.25 years with a male:female ratio of 1.3:1. Of the 35 cases, microvascular proliferation was seen in 23 cases. Large foci of necrosis (>50%) were seen in 10 cases and 27 cases had mitotic count ≥ 5/high power field (HPF). Of 35 cases, 5 (14.3%) cases showed IDH1 immunopositivity and 30 (85.7%) cases were negative for IDH1. ATRX was retained in 24 (68.6%) cases, while it was lost in 11 (31.4%) cases. The p53 immunoexpression was seen in 31 (88.6%) cases, whereas p53 was negative in 4 (11.4%) cases. The overall median survival (OS) was 6 months. In two protein pairs, the three compositions were IDH1–/p53+ (74.3%), ATRX +/IDH1– (62.9%), and ATRX +/p53+ (57.1%). Combined three-protein immunohistochemical analysis revealed five different molecular variants. Also, 8.6% (3/35) of the samples had aberrant protein expression of all three proteins, i.e., ATRX–/p53 +/IDH1 + , while 11.4% (4/35) were wild-type protein expression group, i.e., ATRX +/p53–/IDH1–.

Conclusion In patients with single protein expression, Kaplan–Meier survival analysis showed statistically better OS in IDH1 mutant glioblastomas. In cases with double protein pairs, IDH1/p53 revealed statistically significant association with better median OS. The survival analysis of patients with IDH1/ATRX/p53 protein combinations also denoted a better OS. Hence, GBM can be grouped into prognostically relevant subgroups using these protein expression signatures individually, as well as the combined protein expression signatures.
Redesigned sewage pump tip clears the way for improved wastewater treatment
Authors: Johnson-Groh Mara
Published: March 2024

A T-shaped pump impeller design keeps sewage flowing smoothly.
Structural and electronic transformations of GeSe
2
glass under high pressures studied by X-ray absorption spectroscopy
Authors: Mijit Emin , Durandurdu Murat , Rodrigues João Elias F. S. , Trapananti Angela , Rezvani S. Javad , Rosa Angelika Dorothea , Mathon Olivier , Irifune Tetsuo , Di Cicco Andrea
Published: March 2024

Pressure-induced transformations in an archetypal chalcogenide glass (GeSe
2
) have been investigated up to 157 GPa by X-ray absorption spectroscopy (XAS) and molecular dynamics (MD) simulations. Ge and Se K-edge XAS data allowed simultaneous tracking of the correlated local structural and electronic changes at both Ge and Se sites. Thanks to the simultaneous analysis of extended X-ray absorption fine structure (EXAFS) signals of both edges, reliable quantitative information about the evolution of the first neighbor Ge-Se distribution could be obtained. It also allowed to account for contributions of the Ge-Ge and Se-Se bond distributions (chemical disorder). The low-density to high-density amorphous-amorphous transformation was found to occur within 10 to 30 GPa pressure range, but the conversion from tetrahedral to octahedral coordination of the Ge sites is completed above

∼

80 GPa. No convincing evidence of another high-density amorphous state with coordination number larger than six was found within the investigated pressure range. The number of short Ge-Ge and Se-Se “wrong” bonds was found to increase upon pressurization. Experimental XAS results are confirmed by MD simulations, indicating the increase of chemical disorder under high pressure.
Fractional Ito calculus
Authors: Cont Rama , Jin Ruhong
Published: March 2024

We derive Itô–type change of variable formulas for smooth functionals of irregular paths with nonzero

p
p

th variation along a sequence of partitions, where

p
≥
1

p \geq 1

is arbitrary, in terms of fractional derivative operators. Our results extend the results of the Föllmer–Itô calculus to the general case of paths with ‘fractional’ regularity. In the case where

p
p

is not an integer, we show that the change of variable formula may sometimes contain a nonzero ‘fractional’ Itô remainder term and provide a representation for this remainder term. These results are then extended to functionals of paths with nonzero

ϕ
\phi

-variation and multidimensional paths. Using these results, we derive an isometry property for the pathwise Föllmer integral in terms of

ϕ
\phi

-variation.
Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis
Authors: Parolek Jan , Burd Christopher G.
Published: March 2024

Bridge-like lipid transfer protein family member 2 (BLTP2) is an evolutionary conserved protein with unknown function(s). The absence of BLTP2 in Drosophila melanogaster results in impaired cellular secretion and larval death, while in mice ( Mus musculus), it causes preweaning lethality. Structural predictions propose that BLTP2 belongs to the repeating β-groove domain-containing (also called the VPS13) protein family, forming a long tube with a hydrophobic core, suggesting that it operates as a lipid transfer protein (LTP). We establish BLTP2 as a negative regulator of ciliogenesis in RPE-1 cells based on a strong genetic interaction with WDR44, a gene that also suppresses ciliogenesis. Like WDR44, BLTP2 localizes to membrane contact sites involving the endoplasmic reticulum and the tubular endosome network in HeLa cells and that BLTP2 depletion enhanced ciliogenesis in RPE-1 cells grown in serum-containing medium, a condition where ciliogenesis is normally suppressed. This study establishes human BLTP2 as a putative LTP acting between tubular endosomes and ER that regulates primary cilium biogenesis.
Understanding Policy on Women and Employment
Authors: Milner Susan
Published: March 2024

Comparative feminist scholarship distinguishes between status-based and class-based policies; the former are regulatory and address women’s inferior and vulnerable status in relation to men, while class-based policies have a redistributive dimension and address women’s economic disadvantage as carers or low-paid workers. While women’s ministerial presence and women’s policy machinery are thought to account for the former, left-of-centre parties in government are more likely to drive class-based policies. Alternative explanations for policy adoption derive from regime theories, such as welfare regime theory. This chapter considers the policy agenda of the gender pay gap, through analysis of Westminster parliamentary debates. It finds support for regime theory in the framing of debates and confirms partisan politics and feminization of parliament and government as drivers of the timing and volume of debates.
Familial Transmission of Essential Hypertension: Genes, Environments, and Chronic Anger
Authors: Ewart Craig K.
Published: March 2024

Families transmit risk for essential hypertension (EH) via parents' genes and through learned patterns of behavior. Evidence linking anger with EH risk and the success of family-based approaches to early risk reduction create a need to understand how families might transmit heightened vulnerability to chronic anger arousal. Behavioral genetic research suggests that trait hostility, like high blood pressure, is heritable, and that social environments influence genetic expression. Yet pathways by which family environments foster chronic anger may not be the parenting behaviors emphasized in prominent theories of child development. Instead, research reviewed in this article suggests that susceptibility to frequent, prolonged anger is affected more by unshared family experiences arising out of marital discord, intra-familial alliances, and asymmetrical sibling interaction patterns. These processes influence the development of social competence, defined in terms of self-directive goals, self-evaluative standards, and social influence skills. Competence deficits foster persisting vulnerability to a syndrome of strong negative interpersonal emotions associated with heightened cardiovascular reactivity and disease risk. Early family intervention may prevent or modify these deficits.
Cognitive-Behavioral Treatment of Rheumatoid Arthritis: A Preliminary Review of Efficacy and Methodology
Authors: McCracken Lance M.
Published: March 2024

Rheumatoid arthritis (RA) is a chronic, painful, and debilitating disease which affects approximately 1% of the adult population. A great deal of literature suggests that psychological factors are important to patient outcomes in RA. This article discusses these factors and then reviews the cognitive-behavioral treatment literature for this population. Although cognitive-behavioral treatments appear to assist RA patients in managing their pain, additional findings are inconsistent and methodological limitations in the literature preclude firm conclusions. A final section of this paper presents suggestions to improve the design of future studies evaluating cognitive-behavioral treatments for these patients.
Health Through Cholesterol Reduction: Are there Unforeseen Risks?
Authors: Muldoon Matthew F. , Manuck Stephen B.
Published: March 2024

While abundant scientific evidence documents the risks of untreated hypercholesterolemia, long-term cholesterol-lowering could also be associated with adverse health effects. This article discusses potential connections between reduced serum cholesterol levels and three specific adverse outcomes: (a) cancer, (b) hemorrhagic stroke, and(c) death from non-illness related causes (suicide, accident, or violence). Included are data from epidemiologic studies of both serum cholesterol and dietary fat consumption, and evidence from randomized, clinical trials of cholesterol lowering with either dietary or pharmacologic treatment. While some evidence links reduced serum cholesterol with each of these three illnesses or events, the inconsistencies and limitations of the available evidence presently preclude conclusions regarding either the safety or dangers of cholesterol-lowering treatments.
Smoking Among Women Across the Life Span: Prevalence, Interventions, and Implications for Cessation Research
Authors: Ockene Judith K.
Published: March 2024

Smoking has a significant effect on the major causes of death and disability among America's women—coronary heart disease, stroke, cancer, and osteoporosis. In addition, when pregnant women smoke, they not only adversely affect themselves but also the health, development, and functioning of their unborn and young children. Although the prevalence of smoking among women in the United States has been declining over the last two and a half decades, the data indicate that women lag behind men in the degree to which they have reduced their smoking. Initiation of smoking continues to be a major problem for young women, especially those of low educational attainment. The differences in changes in smoking rates between men and women and for women at different educational levels suggest the need for targeted smoking cessation programs which address issues of specific concern to women smokers, such as weight gain and stress reduction, and those of concern to individuals of lower educational levels.

This article provides information regarding the prevalence and onset of smoking among women and rates of cessation across the life span, with a special emphasis on smoking during reproductive and child-raising years. A major focus is the review of the scientific literature on intervention strategies found to be efficacious in the health care sector with women smokers, giving special emphasis to interventions with pregnant women. The implications of the research outcomes for identifying research needs in clinic-based smoking interventions for women and for the training of health care professionals to intervene with women smokers are also discussed.
Forging future outreach
Authors: Wilkes Belinda
Published: March 2024

Presenting an overview of a meeting to discuss strategy for RAS outreach, engagement and education activities
How much iron is in the Sun?
Authors: Foxon Floe
Published: March 2024

The Sun makes up 99% of the mass of our solar system: to understand it is to understand ourselves. We flip through the literature to chart our understanding.
Plant–soil interactions during the native and exotic range expansion of an annual plant
Authors: Lustenhouwer Nicky , Chaubet Tom M R , Melen Miranda K , van der Putten Wim H , Parker Ingrid M
Published: March 2024

Range expansions, whether they are biological invasions or climate change-mediated range shifts, may have profound ecological and evolutionary consequences for plant–soil interactions. Range-expanding plants encounter soil biota with which they have a limited coevolutionary history, especially when introduced to a new continent. Past studies have found mixed results on whether plants experience positive or negative soil feedback interactions in their novel range, and these effects often change over time. One important theoretical explanation is that plants locally adapt to the soil pathogens and mutualists in their novel range. We tested this hypothesis in Dittrichia graveolens, an annual plant that is both expanding its European native range, initially coinciding with climate warming, and rapidly invading California after human introduction. In parallel greenhouse experiments on both continents, we used plant genotypes and soils from 5 locations at the core and edge of each range to compare plant growth in soil inhabited by D. graveolens and nearby control microsites as a measure of plant–soil feedback. Plant–soil interactions were highly idiosyncratic across each range. On average, plant–soil feedbacks were more positive in the native range than in the exotic range. In line with the strongly heterogeneous pattern of soil responses along our biogeographic gradients, we found no evidence for evolutionary differentiation between plant genotypes from the core to the edge of either range. Our results suggest that the evolution of plant–soil interactions during range expansion may be more strongly driven by local evolutionary dynamics varying across the range than by large-scale biogeographic shifts.
(O-06) PREVALENCE OF CLIMACTURIA IN POST RADICAL PROSTATECTOMY PATIENTS IN REFERRAL HOSPITAL IN BOGOTA
Authors: Garcia S , Diaz Ritter C , Peña Rodríguez S , Fernandez Mantilla D , Khoshbin F
Published: March 2024

Introduction

Climacturia is a frequent complication of radical prostatectomy (RP). Pelvic floor involvement and urinary sphincter functionality play a vital role in its pathophysiology. The prevalence in Colombia is unknown, and it is currently an underdiagnosed entity. This study aims to estimate the prevalence of climacturia in men undergoing RP in a fourth-level hospital in Bogota from 2018 to 2023.

Methodology

A descriptive cross-sectional observational study was conducted. Patients who attended postoperative control for 6 months and 1 year after a RP in the institution were included. A standardized survey was applied evaluating the presence of urine leakage during sexual arousal and/or orgasm and standardized scales of urinary incontinence and sexual function.

Results

Forty-four patients were included. The mean age of the patients was 64.7 (range: 45-81). The distribution of the surgical approach used in these patients is shown in Table 1. 56,8% (n=25) reported urine leakage during arousal. Of these patients, 43.1% (n=19) had received robot-assisted radical prostatectomy (RARP), followed by open surgery with 13,6% (n=6) of patients reporting this symptom. On the other hand, 38,6% (n=17) of patients had urine leakage during orgasm, of which the highest proportion of this symptom was open surgery. A limitation of the study was the lack of active search for this pathology in the general urological consultation and the poor response of patients to the forms.

Conclusions

The prevalence of climacturia is high and its diagnosis has multiple limitations. In addition, other post-prostatectomy side effects were identified, such as urine leakage with arousal, whose prevalence was higher than that of climacturia and may affect the sexuality of patients. Additionally, considering these are the preliminary findings from a prospective study, a larger sample size is required to achieve more representative results.

Financing

No conflict.
(O-08) IMPACT OF SUBINGUINAL MICROSURGICAL VARICOCELECTOMY ON MALE INFERTILITY: SEMINAL PARAMETERS, SERUM TESTOSTERONE, AND PREGNANCY RATE - RETROSPECTIVE COHORT AT A UNIVERSITY HOSPITAL IN RIO DE JANEIRO
Authors: Crelier G M , Vasconcelos C V O , Nunes D P , Vidal V A , Diniz V S , Schiavini J L , Filho RdTeF , Junior H R J , Lara C M C , Damião R
Published: March 2024

Introduction and Objective

Varicocele is the most common identifiable cause of male infertility, and varicocelectomy is the most frequently performed surgery for its treatment. This condition impacts infertility cases and sperm quality. Microsurgical varicocelectomy is considered the gold standard treatment for varicocele. This retrospective cohort aims to evaluate the effects of microsurgical varicocelectomy on seminal parameters, serum testosterone, and pregnancy rate in the context of male infertility in 39 patients who underwent the procedure at a university hospital in Rio de Janeiro.

Methods

This study is a retrospective cohort conducted between January 2016 and February 2023, involving 39 men who underwent subinguinal microsurgical varicocele repair in the context of marital infertility. Pre- and post-operative analyses of seminal parameters were based on the criteria of the World Health Organization from 2010. Post-operative semen analysis and serum testosterone levels were assessed 3 to 6 months after varicocelectomy. The pregnancy rate was observed through interviews until February 28, 2023.

Results

Subinguinal microsurgical varicocelectomy is associated with a significant increase in testosterone levels and an improvement in seminal parameters, all with statistical significance. Testosterone levels increased by an average of 84.2 (±14.7) ng/dl. The pregnancy rate also increased significantly, with 51.3% of couples achieving pregnancy as of the time of this study.

Conclusion

In this patient population, infertile men with clinical varicocele who underwent subinguinal microsurgical varicocelectomy showed a significant increase in testosterone levels, improvement in seminal parameters, and a significant reduction in the proportion of azoospermia. Furthermore, there was an increase in the occurrence of pregnancy in couples with marital infertility.

Statistical Results

 

Financing

No conflict.
(O-12) MODULATION OF MMP EXPRESSION AND COLLAGEN DEPOSITION IN THE TUNICA ALBUGINEA IN PEYRONIE´S DISEASE INDUCED AFTER TREATMENT WITH MYCOPHENOLATE MOFETIL
Authors: Facio F , Antoniassi T , Rocha Ruiz T F , Taboga S , Jacovaci Colleta S , Falleiros Junior L R
Published: March 2024

Peyronie's disease (PD) is a progressive fibrotic disorder affecting the tunica albuginea (TA) of the penis. MMF was evaluated previously after experimental induction of PD. We investigate the modulation of metalloprotease (MMP) expression and collagen deposition in the TA in PD induced after treatment with MMF in rats. Rats were divided into: control group; sham (injection of saline solution); only TGFβ injection (7 or 30 days); TGFβ injection and treatment with MMF (7 or 30 days). Samples were collected for histochemical and immunohistochemistry, measurements of collagen fibers and MMP expression were performed in random fields. Statistical analyses were checked for normality using the Kolmogorov-Smirnov test, followed by ANOVA test or Kruskal-Wallis test.

Results

Collagen type I (COLI) was decreased in 7 and 30 days (43.19% ± 1.22; 38.14%1.23), and collagen type III (COLIII) was increased in both periods in the TGFβ induction (56.81% ± 1.22; 61.86% ± 1.23). COLI/COLIII ratio of MMF treatment (7 days) was enhanced (54.74% ± 2.86; 45.26% ± 2.88). COLI (7 and 30 days) were statistically different, as well as 30 days of MMF treatment decreased COLIII (27.41% ± 3.11). MMP was increased at 7 days after TGFβ induction. However, 30 days after induction, MMP expression decreased (1.67% ± 0.16), whereas, with MMF treatment, increased (2.44% ± 0.22). MMP3 expression was similar in both groups. Within 7 days, MMP was enhanced (4.77% ± 0.37; 4.43% ± 0.43) and decreased in 30 days (3.73% ± 0.38; 3.20% ± 0.33). MMP presented an enhancement at 7 days in TGFβ-induction, with (17.56% ± 0.97) or without (13.41% ± 1.31) MMF treatment. However, with MMF treatment at 7 days, MMP showed increased values, and, at 30 days, MMP no differences were observed.

Conclusions

Induction with TGFβ promoted an imbalance the COLI/COLIII ratio of the tunica albuginea, and the MMF treatment promoted recovery of collagen status. MMP expression were altered, and MMF promoted the collagen recovery by MMP modulation.

Financing

No conflict.
(O-19) GENDER REASSIGNMENT IN TRANSGENDER MEN IN BOGOTá, COLOMBIA
Authors: Coronado Villarreal M J , Fehrmann Rivera S , Montenegro Gutiérrez M J , Peña Plazas L N , Ramírez Salguero L V , Sánchez Otero V
Published: March 2024

Introduction

In the 21st century, the transgender population begun to have greater visibility and advances within the health field in terms of gender reassignment. This transition covers four aspects which includes legal, social, surgical reassignment and hormone therapy. Although the word transgender is no longer in the disorders section, it’s still seen as a disease. For this reason, the transgender population continues to be pathologized. In Bogotá, Colombia, information on the processes that encompass gender reassignment is currently not sufficient.

Objective

To understand the perception of transgender men about the four aspects of the female-to-male gender reassignment currently taking place in Bogotá.

Method

Qualitative descriptive study with biographical/narrative design carried out using semi-structured interviews were conducted with 4 transgender men over 18 years who have completed at least one of the aspects in Bogotá. These interviews were audio recorded, transcribed and analyzed. The results were divided into 2 dimensions, which were subdivided into various categories.

Results and discussion

Once gender reassignment began, most transgender men opt to start with the social aspect because it allows them to present themselves to society in their desired way. After this, they continued with the legal, hormonal and surgical aspects according to each person's preference. As a result, a lack of protocols and poor follow-up of health care guidelines for adequate care of this population were evident.

Financing

No conflict.
(O-24) EFFICACY OF ASPIRATION AND SCLEROTHERAPY FOR HYDROCELE: A SYSTEMATIC REVIEW
Authors: Freitas F C , Sanches M R , Dosatti AdC
Published: March 2024

Introduction and Objetives

Hydroceles are abnormal collection of fluid between the parietal and visceral layers of the tunica vaginalis. Traditionally, surgical excision and or repair under general anaesthesia has been the standard of care, but sclerosant therapy can be used safely and with efficacy for hydrocele’s treatment. This study aims to review and elucidate the current literature sclerotherapy for hydrocele.

Methods

We searched for articles in Pubmed, Embase and Cochrane evaluating aspiration and sclerotherapy for hydrocele treatment. Search terms were “hydrocele” and “sclerotherapy”. Relevant papers references were full reviewed searching for new articles. The sclerosing agents considered eligle were phenol, tetracycline, sodium tetradecyl sulfate, phenol and alcohol.

Results

We included 1554 patients from 26 studies. Mean aspirative hydrocele volume was 238,3 mL. Cure rate was seen in 58,3% to 76% after a single procedure in STDS studies and 70% to 94,11% overall success. Phenol’s studies demonstrated a 47.5% to 70% cure rate with one sclerotherapy and 96.5% to 100% overall success. In Sclerotheraphy with tetracycline cure rate after a single procedure was 57% to 100% and overall success was 77% to 100%. Of the polidocanol group, cure rate was 42.3% to 62.1% after one sclerotherapy and overall success was 51.7% to 94%. Finally, in alcohol’s group we found 50% to 76.12% after one procedure and 80% to 97.62%.

Conclusion

A better cure rate after one procedure was observed with tetracycline and overall success after multiples procedures was seen with phenol. Due to heterogeneity and biases of the studies, more controlled clinical trials must be done to elucidate the best sclerosant agents.

Financing

No conflict.
(O-30) ONLINE GROUP THERAPY ASSOCIATED WITH PAROXETINE HYDROCHLORIDE FOR COMPULSIVE SEXUAL BEHAVIOR DISORDER´S TREATMENT: A CASE REPORT
Authors: Abensur M , Calle Roldán N M , Mutti K T , Abdo C H N
Published: March 2024

Compulsive Sexual Behaviour Disorder (CSBD) is characterized in ICD-11 as a persistent inability to control intense sexual urges resulting in repetitive sexual behaviours and negative effects in personal life.

Due to the limited research on CSBD´s treatment, our goal is to report a successful case of 39-year-old symptomatic male patient, treated in a structured closed online group focused on self and CSBD´s knowledge, new habits acquisition, particularities of these patients´ profile, associated with medication use.

Method

the information in this report were obtained through patient interviews, psychiatric and psychological records and literature review.

The treatment took place in an outpatient service specialized in sexuality at a public institution. Following CSBD diagnosis, Paroxetine Hydrochloride (20mg/day) was prescribed with regular psychiatric follow-ups. And was referred to an online psychotherapy group consisting of 4 CSBD participants, 2 therapists, weekly 1-hour sessions held for 10 months. The therapy addressed pertinent issues to the treatment and utilized neuropsychoeducational sessions to establish new habits, along with reflective “homework” tasks.

Results

Psychotherapeutic treatment enhanced self-knowledge leading to a loss of meaning to his compulsive behaviours, therefore, a decrease in its frequency. The patient developed a healthy sexuality, free from guilt and risky behaviours, improved emotional management and diversified interests.

Paroxetine Hydrochloride (20mg/day) facilitated the psychotherapy process (10 months), allowing gradual dosage reduction upon symptom alleviation.

Conclusion

The combination of themed online group psychotherapy, a well-established group bond, neuropsychoeducation, and medication effectively addressed CSBD symptoms, enhanced emotional management, and improved quality of life. The positive outcome encourages future research into this treatment approach for CSBD.

Financing

No conflict.
(O-32) PRIMARY DEPTH DYSPAREUNIA IS CAUSED BY THE INCOMPATIBILITY OF THE SIZE OF THE PENIS WITH THE VAGINA
Authors: Matthes AdCS
Published: March 2024

Introduction/Objective

Dyspareunia, to this day, is not yet fully understood. It is known that the size of the distended vagina is variable, as well as the size of the penis.

A vagina distended by a larger penis, suffers trauma and pain. The work aims to measure the flexibility of the human vagina, to guide professionals, who treat women with this complaint.

Methods

Women who signed the informed consent form and underwent vaginal surgeries under anesthesia had their vagina measured in the specular examination according to the POP-Q (total length of the vagina, measurement from the hymen to the deepest portion of the vagina) and also the same measurement with maximum distension of the vagina verified by the resistance to the introduction of a centimetric device. The difference in the measurements obtained determined the flexibility of the vagina in centimeters.

Results

A total of 120 vaginas were measured. The smallest vagina, measured without distention, was 5 centimeters and with distension of 10 centimeters. The largest, without distension, was 13.5 centimeters and with distension of 16 centimeters. Women with genital prolapse showed greater flexibility, ranging from 0.5 cm to 8 cm.

Conclusions

1-The largest measured distention of a vagina was 16 centimeters, which implies that penises larger than 16 centimeters, if penetrated completely, will cause some degree of vaginal trauma. 2-The smallest distended vagina measured 10 centimeters, so any penis that penetrates 10 centimeters into the female vagina will not cause trauma. 3-Women with complaints of pelvic pain associated with depth dyspareunia should be advised about trauma to the vaginal fundus or presence of gynecological pathology, as well as Relative Short Vagina Syndrome. 4-Professionals who serve women and couples need to understand this new concept of depth dyspareunia. However, further well-controlled studies should be conducted to consolidate this new knowledge.

Financing

No conflict.
(O-37) PORNOGRAPHY CONSUMPTION AND SEXUAL SATISFACTION IN BRAZILIAN ADULTS
Authors: Cini da Cunha M E , Fernandes Soares G , Fernanda Habigzang L
Published: March 2024

Introduction/Objective

It is estimated that, worldwide, 40 million adults watch pornography regularly. Understanding sexuality as a social construction and sexual satisfaction as a construct with emotional, relational, physical and cultural characteristics. The aim of this research is to understand the relationship between pornography consumption and the sexual behaviors of its consumers; and compare pornography consumption, considering the gender of consumers.

Material and Methods

Quantitative, correlational and cross-sectional study. The following instruments were used: sociodemographic questionnaire, questionnaire on pornography consumption (frequency, type, form of use, source of content, age of first access and motivation for use), questions on condom use and a rating scale. emotional sexual satisfaction. In total, 993 adults responded to the online survey.

Results

Pornography consumption patterns differed according to the gender of consumers, in relation to the age of first exposute to pornography, frequency and motivation for consumption. Men started consumption earlier and have a higher frequency of consumption compared to women. Men report use for excitement, avoidance of uncomfortable feelings, and boredom. Among women, use involves sexual activity with a partner, curiosity and learning different practices. In the network analysis, gender played a mediating role between pornography consumption and emotional sexual satisfaction. Condom use was not related to sexual satisfaction or pornography consumption. The violent pornography consumption score was a predictor of lower levels of emotional sexual satisfaction.

Conclusions

Pornography consumption, both violent and non-violent, and being male are associated with lower levels of emotional sexual satisfaction. Such results can support interventions to promote sexual health.

Financing

Bolsa PRO-Stricto Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS).
(O-39) CIRANDA- HUMAN BEHAVIOR AND SEXUALITY: EXPERIENCE OF A SEXUAL EDUCATION SERVICE IN BRAZIL
Authors: Castiglione M , Bressani V
Published: March 2024

Introduction

Sexuality Education is a comprehensive educational process that includes knowledge, skills and values that enable children, young people and adults to make conscious and responsible decisions about their sexual experiences and sexuality. Addresses topics such as biological sex, sexual health care, sexual orientation, gender identity and gender expression.

Objective

Describe the dynamics of an interdisciplinary service that aims to promote sexual education of people, in person and/or in a virtual environment.

Materials and Methods

Ciranda-Sexuality and Human Behavior is a sexual education service created in November 2019 by a physiotherapist and a psychologist, specialists in Human Sexuality where together they promote educational actions with a theoretical-scientific basis, in an in-person and virtual environment, such as conferences and conversation circles, live broadcasts and promotion of educational materials, posted through social networks, networks such as Instagram and other communication channels, with the aim of promoting the improvement of the exercise of sexuality by addressing various educational topics. sexual for the population.

Results

In December 2019, a conversation round was held with the presence of 20 women. With the pandemic, at the beginning of 2020, Ciranda's activities became virtual, where the presence of people from different parts of Brazil and other countries was possible. In March 2020, with the support of a marketing consultant, an Instagram page was developed where we have reached 2035 followers to date, 241 posts with educational content including videos, texts with accessible vocabulary and live streams viewed. In addition, we held talks and roundtables through the Google Meet platform for approximately 100 women. In 2022 we return to face-to-face activities

Financing

No conflict.
(PM-01) SEXUAL SATISFACTION POST PENILE PROSTHESIS IMPLANTATION
Authors: Silva-Herrera J M , Martínez-Pinedo C , Varela-Herrera D , Huertas-Cañas J M , García-Torres J S
Published: March 2024

Introduction

Erectile dysfunction is defined as the persistent inability to achieve or maintain an erection sufficient for a satisfactory sexual relationship. In some cases, it is refractory to pharmacological treatments, or these treatments are contraindicated, leading to the consideration of using a penile prosthesis as a definitive treatment. While reported patient and partner satisfaction rates are high (82 – 97%), dissatisfaction has been found to be attributed to various reasons, including prosthesis dysfunction and/or unmet patient expectations regarding the quality of the erection and sexual satisfaction.

Methods

An analytical observational bidirectional cohort study approved by the institutional ethics committee was conducted. Subsequently, patients who underwent penile prosthesis implantation between January 2017 and June 2021 at a single center were identified.

Results

A total of 47 cases were analyzed, with an average age of 64 years. Overall satisfaction with the penile prosthesis implantation was 100%. 94.1% felt that their treatment expectations were met, 88.2% reported continuing to use this method, and 100% were satisfied with the duration of the erection.

Conclusions

A 100% overall global satisfaction rate was observed. High rates of sexual satisfaction in patients were evident, reaffirming the penile prosthesis as a safe procedure that should be offered as a third-line treatment or when a permanent solution is desired.

Financing

No conflict.
(PM-03) EPIDEMIOLOGICAL PROFILE OF PATIENTS UNDERGOING PENILE DOPPLER ULTRASOUND AT A FEDERAL UNIVERSITY HOSPITAL IN BRAZIL
Authors: Lima V F N , Almeida GECd , Gamberini P D C , Milanez C , Lucas D C , Bechara G R , Borges C F
Published: March 2024

Introduction

Erectile Dysfunction (ED) refers to the inability to achieve or sustain a satisfactory erection for sexual intercourse. In Brazil, the estimated prevalence of ED among adults aged 40 to 70 years is 42.1%. For the evaluation of primary erectile dysfunction and preoperative assessment of Peyronie's disease, Penile Doppler ultrasound, involving drug-induced is recommended. This study aims to provide insights into the epidemiology of patients undergoing penile Doppler ultrasound at a Federal University Hospital.

Methods

This retrospective study gathered data from the electronic medical records of 179 patients who underwent the examination between March 2021 and March 2023, using the Phillips Affiniti 50G device. Pharmacological induction with 10 mcg/ml Alprostadil, 30 mg/ml Papaverine, and 1 mg/ml Phentolamine. Initially, 0.1 ml of this mixture was applied to the penile shaft, with subsequent adjustments made to achieve the best maximal erection.

Results

The participants ages ranged from 20 to 80 years, with an average of 59.8(±11,42) years. Marital status distribution showed 139 married and 40 were single. Ethnically, there were 57 white, 69 individuals of mixed race, and 39 black. The average Body Mass Index was 26.6(±4,13). The majority of patients identified as heterosexual (174 patients), with 51 cases of hypertension and 31 cases of diabetes. Additionally, 62 patients had radical prostatectomy. Out of the 134 patients that performed the exam with the report of erectile dysfunction, 54 were diagnosed with arterial insufficiency and 09 had venous leakage. Among the 42 exlcusive clinical report of Peyronie’s, 76% exhibited a uniplanar curvature located in the dorsal region. The average curvature angle was 47°(±19,5).

Conclusion

Erectile dysfunction was significantly more prevalent than Peyronie's disease. Among Peyronie's patients, uniplanar curvature, especially in the dorsal region, was the most common deformity type.

Financing

No conflict.