bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Study on the Mining Accidents Due to Unsafe Behaviour of Machinery Operators
Authors: John Gladious J. , Abishek S. , Prashanth T. , Praveen B. , Kirubagaran Earnest R.
Published: July 2024

The main objective of this study was to investigate the underlying factors contributing to unsafe behavior among machinery operators through questionnaires distributed among a sample of 48 operators. Data analysis conducted via SPSS software and Spearman analysis revealed several key contributors to unsafe behavior. These factors encompassed demographical aspects (such as age and educational background), job-related stress, dissatisfaction at work, social support, and the impact of addictive behaviors. Spearman correlation analysis further elucidated the interconnectedness among these variables offering insights valuable in mitigating unsafe behaviors.
Közmondás vagy szállóige-e a Nem kell mindig kaviár?
Authors: Tóth Szilárd Tibor
Published: July 2024

A Magyar közmondások nagyszótárában (és előzményében, a Magyar közmondástárban) a Nem kell mindig kaviár frazeologizmus ʼnem kell mindig a legjobb, a legdrágább, legfinomabbʼ jelentésben szerepel (T. Litovkina 2005: 324, 2010: 324). Más nagyobb magyar frazeográfiai és parömiográfiai munkákban (Forgács 2003, Ujváry [2003], Bárdosi 2015, Szemerkényi 2019) nem jelenik meg, pedig a kaviár szó 1783 óta adatolt a magyarban (TESz. 2: 413, ÚESz.). A frazeologizmus, amit Johannes Mario Simmel „Es muss nicht immer Kaviar sein” című regényéből készült, Magyarországon 1982-ben bemutatott tévéfilmsorozat terjesztett el, inkább szállóige vagy szállóige eredetű helyzetmondat, mintsem közmondás. Felmérésem tanúsága szerint nem tekinthető általánosan elterjedtnek, de nem mutatja a közmondás formai jegyeit sem, például a p → q logikai szerkezetet. A német eredetinek a német frazeográfiai irodalomban (Duden 2002: 392, Duden 2017: 403) megadott jelentése megfelel a T. Litovkina megadta jelentésnek. A kaviár komponens meglehetősen ritkán fordul elő az európai proverbiumkincsben, bár nem teljesen ismeretlen. Az angolban elterjedt caviar(e) to the general frazeologizmus szintén ismert szerző, Shakespeare tollából származik.
Iron disulfide is promising positive electrode material for lithium power battery
Authors: Polishchuk Y. V. ,   Ukrainian State Chemical and Technological University, Maksyuta I. M. , Shembel' E. M. ,   Ukrainian State Chemical and Technological University,   Enerize. Corp, Coral Springs, FL, USA
Published: July 2024

Comparative characteristic of natural and synthesized iron disulfide has been carried out. Physical, chemical and macrostructure characteristics of pyrite powders have been shown. By the methods of cyclic Vtammetry the electrochemical properties of FeS2 – based cathodes have been investigated in non-aqueous liquid (1М LiClO4; PC+DME) and polymer (CPVC; 1М LiClO4; PC) electrolytes.
Six Sigma as a Methodology to Reduce Weight Variability: Antonio Dairy Case Study
Authors: Santander Romero W , Moyano Alulema J , Guamán Lozano A , García Cabezas E
Published: July 2024

The purpose of this was to improve the procedure for making cheese in the Antonio dairy company applying Six Sigma. The following work was presented, which focused on reducing the variability of the weight of the units made. It begins with the DMAIC methodology in the definition phase of the problem with the data record of the productive part to apply tools such as the five whys, Ishikawa diagram, analysis of variances. The mixed experimental design of three factors is executed, taking into account the discharge speed of the curd, hardening time, and the operators who work in the process, where it is determined that 70.26% of the variability of the weight of the cheeses are caused by these three factors. In the part that corresponds to results in the improvement of the production process of the product detailed in this study, it is focused on these important points. Regarding the application of the improvement of the process, a 15 minutes increase is made in the hardening of the curd after having carried out the standardization in the unloading taking speed as a variable. In said improvement, all the personnel that work in the dosing machine, thus managing to reduce variability by 24.37% and likewise reduce the number of cuts and waste in the production line with a saving of 44,616 USD per year.
Keywords: Six Sigma, DMAIC, variability of weights, standardization, dairy.
Corruption Combating Strategies in China
Authors: Iskakov Oleg M. ,   Postgraduate Student of the Department of Administrative and Information Law of the M.M. Speransky
Published: July 2024

The article observes the problems of the anti-corruption strategy in the People's Republic of China that have taken place over the years, with a focus on the efforts made to control and prevent corruption. First of all, it tells about the efforts to fight corruption, which were implemented in the form of periodic intensive anticorruption campaigns. The study also touches on the modernization of Chinese anti-corruption strategy, its transition from the style of campaigns to the construction of rules that combine both pre-regulation and post-factum punishment. Finally, the model of the united centralized anti-corruption agency is considered with the establishment of the National Supervisory Commission as an overarching body to oversee all anti-corruption work. It also examines the practice of adjusting the structure of the dual leadership of local commissions for discipline inspection, where the powers of higher commissions for discipline inspection prevail over the powers of local party committees in investigating cases of corruption. This practice is interesting, including from the point of view of its scope. It is concluded that the creation of a dominant anti-corruption body can be an effective example of how a system is formed to counter and prevent corruption.
Special Aspects of a Victim of Violent Crimes in the Sphere of Family and Domestic Relations
Authors: Filippova Elena O. ,   Associate Professor of the Department of Criminal Law of the Orenburg State University, PhD (Pedagogy), Associate Professor
Published: July 2024

The role of a victim in domestic violence can be complex and multifaceted. Victims often find themselves in a vulnerable position, being physically, emotionally or sexually abused. They may experience fear, shame, humiliation, and a sense of hopelessness. Many victims of domestic violence feel trapped in their own homes and face difficulties in trying to get out of a violent situation. However, it is important to note that victims of domestic violence cannot bear the blame for what is happening. They are victims of violence, and the responsibility for violence lies entirely with the abusers. Victim support and the creation of safe protection mechanisms are important aspects of combating domestic violence and helping victims rebuild their lives. This topic in the Russian Federation is of a global nature, since domestic violence often leads either to severe physical injury or to the death of the victim, and responsibility for such crimes is not fixed at the legislative level.
International Electronic Trade: Legal Regulation Novelties
Authors: Agamagomedova Saniyat A. ,   Senior Research Scientist of the Institute of State and Law of the Russian Academy of Sciences, PhD (Law), Associate Professor
Published: July 2024

The paper examines the development of international electronic commerce within the framework of the Eurasian Economic Union (EAEU). Based on the analysis of customs regulation novelties, the author highlights several aspects of upcoming changes in the law of the EAEU related to the regulation of the institution of electronic commerce. The highlighted aspects relate to the terminological apparatus of the EAEU, the subject system of customs legal relations, customs operations and procedures within the framework of electronic trade in goods. A conclusion is made about the gradual formation of a comprehensive institution of electronic commerce in the EAEU, combining the norms of private and public law. The author predicts the introduction of changes and additions to national legislation on administrative responsibility and consumer protection in connection with the development of regulation of electronic commerce at the EAEU level.
Microdetermination of Piroxicam in Pharmaceutical Formulations by Complexation with Fe(III) and Image Scanning Densitometry
Authors: Anwar Jamıl , Dar Amara , Mumtaz Ramna , Anzano Jesús , Mohyuddin Ayesha
Published: July 2024

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain or inflammation due to osteoarthritis or rheumatoid arthritis. Assay of piroxicam in pharmaceutical formulations can be performed by using a number of analytical techniques. This work estimates the drug in commercial samples using a novel method, Computational Image Scanning Densitometry (CISD). Micro-volumes of the aqueous solution of piroxicam were reacted with iron(III) sulfate solution under optimum conditions on a white Teflon well plate to form a pink-colored mononuclear complex. By using a smartphone, the picture of the colored complex in the well plate was taken and transferred to an attached computer. The overall optical density resulting from red, green, and blue (RGB) components from a specific area of the colored image was measured and digitalized with the help of custom-made software. A standard curve was prepared by plotting optical density against piroxicam concentration. The method was simple, fast, adequately precise, and accurate for the assay of the drug in commercial samples. The validity of the new method was checked by comparing the results with those obtained by a standard spectrophotometric method of Piroxicam estimation.
The significance and prognostic, diagnostic, and therapeutic potential of selected paracrine factors in type 2 diabetes
Authors: Kuczera Mariusz , Stocerz Klaudia , Sokal Arkadiusz , Glin Magdalena , Orlińska Kinga , Siwiec Jan , Olczyk Paweł
Published: July 2024

Cukrzyca typu 2 (type 2 diabetes mellitus – T2DM) to jedna z najczęściej występujących współczesnych chorób cywilizacyjnych, odznaczająca się hiperglikemią będącą skutkiem wadliwego wydzielania insuliny przez komórki β trzustki i/lub niewłaściwą wrażliwością tkanek na insulinę. W Polsce zapadalność na tę chorobę metaboliczną wynosi 5–8% i wciąż ma tendencję wzrostową. Konsekwencją rozwoju T2DM są m.in. zmiany w układzie sercowo-naczyniowym, retinopatia, nefropatia i neuropatia. Dzięki postępowi medycyny ułatwione jest kontrolowanie glikemii, jak również predykcja wystąpienia choroby bądź dynamiki jej rozwoju i następstw. Z omówionymi w artykule molekułami – różnicującym czynnikiem wzrostu 15 (growth differentiation factor 15 – GDF-15), śródmózgowym czynnikiem neurotroficznym pochodzenia astrocytarnego (mesencephalic astrocyte-derived neurotrophic factor – MANF) i fetuiną-A – wiążą się duże nadzieje zarówno w diagnostyce, jak i leczeniu nie tylko T2DM, ale również otyłości, która niejednokrotnie towarzyszy T2DM. Większość badań opisywanych w literaturze wykonywana była na modelu zwierzęcym, głównie mysim. Niniejszy artykuł przedstawia argumenty przemawiające za potencjalną użytecznością wspomnianych czynników parakrynnych w celach prognostycznych, diagnostycznych, jak również leczniczych.
Transformational Learning Within African American Culture: What Does Financial Education That Addresses Systemic Inequalities Look Like?
Authors: Serido Joyce , McGee Demitri , Zhang Yue , Li Lijun , Quinones Miguel , Ramos Gabriela
Published: July 2024

Using a grounded theory approach, we investigate the practices of financial educators working in a community program to identify how financial education is taught in the context of historical inequalities and systemic barriers. Framed in the transformative learning theory, we describe how an understanding of the meaning of wealth within the Black community establishes relationships as the foundation for learning the knowledge and skills needed to interact with financial institutions. Based on our findings, we propose a community-focused explanation of interacting with financial institutions as a model for financial education that is applicable and relevant for Black communities and potentially for other marginalized communities that experience systemic exclusion and discrimination.
El catalejo aristotélico o sea, Idea de la aguda e ingeniosa elocución que sirve a toda el arte oratoria, lapidaria y simbólica examinada con los principios del divino Aristóteles, por el conde y caballero de la gran cruz, don Emanuele Tesauro, patricio turinés
Authors: Tesauro Emanuele ,   Independent
Published: July 2024

El catalejo aristotélico (ll cannocchiale aristotelico) del jesuita turinés Emanuele Tesauro (1592-1675) es, sin duda, el más importante tratado de retórica barroca en lengua italiana. En sus páginas encontramos reflexiones sobre múltiples factores que intervienen en la expresión verbal, oral y escrita, pero también en otras manifestaciones comunicativas en donde pueden intervenir las imágenes como vehículo esencial de la comunicación mediante símbolos. A partir del siglo XVI, la difusión de libros de emblemas y empresas despertó el interés por explicar la coexistencia de diferentes códigos comunicativos en un solo mensaje. En su tratado, Tesauro parte de la convicción de que el ingenio humano es capaz de producir mensajes simbólicos cuya recepción dependería también de un intérprete ingenioso, pero, sobre todo, educado y sagaz para identificar los elementos cargados de significados y poderlos decodificar a partir de puntos de referencia anclados en la tradición clásica. Siendo así, este tratado se ofrece como una guía para los futuros practicantes o intérpretes de conceptos agudos en sus múltiples manifestaciones. El presente volumen es el resultado de un trabajo colectivo en el que participaron especialistas en letras clásicas y en literatura barroca. Además de ser una traducción integral, cuenta con un estudio preliminar, un aparato de notas, índices e imágenes que abren las puertas a la lectura de esta pieza fundamental para comprender la estética del Barroco en sus múltiples manifestaciones.
A STUDY ON THE POTENTIAL OF CHINA’S EXPORT TRADE OF AGRICULTURAL PRODUCTS TO THE TEN ASEAN COUNTRIES ---NEW EVIDENCE FROM THE PANEL CS-ARDL MODEL
Authors:   Graduate Institute of Economics,Chiang Mai University, Chiang Mai, Thailand,, He Yantong
Published: July 2024

This paper constructs a Panel CS-ARDL model using annual data for China and 10 ASEAN countries during the period from 2002 to 2022 to study the long- and short-term trade potentials and impacts of China's exports of agricultural products to the 10 ASEAN countries, and measures the trade potential value of China's exports to the 10 ASEAN countries with reference to the existing literature. The study shows that the trade value of agricultural exports is significantly positively correlated with China's GDP, ASEAN's GDP, and ASEAN's population, while it is significantly negatively correlated with China's population, and the results are consistent in the short and long term. After measuring the trade potential value, it is found that China's agricultural export potential to the ten ASEAN countries is overall better, but it is characterized by uneven distribution and unbalanced development. Among them, the trade potential value of Indonesia fluctuates greatly, and the trade potential of Malaysia gradually reaches saturation.
Physical Characterization of Paper Made from Durian Peels and Corn Stalks
Authors: Nuryadin Atin , Fitri Muhammad Fauzan , Wati Retno Rahma , Fadhilah Khairunnisa Hayatul , Subagiyo Lambang , Damayanti Isniawana
Published: July 2024

The increasing demand for paper has significantly impacted the environment due to the heavy reliance on wood as a primary raw material. This study investigates the feasibility of using durian (Durio zibethinus) peels and corn (Zea mays) stalks as alternative raw materials for paper production, focusing on their physical characteristics. The paper pulp was prepared using the soda pulping method with NaOH. Various ratios of durian peels and corn stalks were mixed: 1:0 (A), 0:1 (B), 1:1 (C), 2:1 (D), and 1:2 (E). Results indicated that type D produced the thickest paper, while type A produced the thinnest. The highest grammage was observed in type E, and the lowest in type D. Type C showed the highest absorbency. The tensile and tear indexes were highest in type D and lowest in type C. Type A had the highest mass density, whereas type D had the lowest. The findings suggest that a combination of durian peel and corn stalks exhibits diverse physical properties, indicating their potential use as an alternative to conventional wood-based paper. This approach could reduce the dependency on wood and contribute to environmental conservation.
Hair restoration surgery: pre-surgical considerations and pitfalls
Authors: Tan Mingjuan , Yong Angeline Anning , Wang Etienne Cho Ee
Published: July 2024

Hair restoration surgery is an increasingly common treatment for androgenetic alopecia and may also address other forms of non-scarring and scarring alopecia. To optimise surgical outcomes, it is crucial to consider key pre-surgical factors and avoid diagnostic pitfalls. This review summarises the diagnostic and differential diagnostic approaches to alopecias, as well as a checklist for holistic patient assessment before hair transplantation.
THE INFLUENCE OF ONLINE REVIEWS ON HOTEL ATTRACTIVENESS PERCEPTIONS: A GENDER-BASED COMPARATIVE STUDY
Authors: Šostar Marko , Andrlić Berislav , Ramanathan Hareesh N.
Published: July 2024

Purpose - The primary aim of this research is to explore the differential impact of online hotel reviews on the perceived attractiveness of hotel, with a focus on identifying any variances between genders. It seeks to contribute to the understanding of consumer behavior in the digital age, especially how men and women differently interpret and react to online reviews. Design - Employing a quantitative research design, this study systematically investigates the change in hotel attractiveness perceptions before and after the exposure to online reviews among a sample of male and female participants. The participants were first asked to rate the attractiveness of a one hotel based solely on set of six photographs. Subsequently, they were exposed to online reviews of the same hotel, after which they re-evaluated their perceptions of attractiveness. These repeated measures design allowed for the examination of within-subject changes in perceptions, as well as the interactions between gender and review exposure. Findings - The analysis revealed statistically significant changes in the perceived attractiveness of hotel after reading online reviews, with these changes being more pronounced among male participants compared to female participants. Specifically, both genders exhibited an increase in perceived attractiveness post-review exposure, but the magnitude of change was significantly higher for men. Additionally, the study identified a significant interaction effect between gender and the impact of online reviews, indicating that the influence of reviews on perceived attractiveness is moderated by gender. These findings underscore the potent role of online reviews in shaping consumer perceptions and highlight gender differences in processing this information. Originality - This research contributes to the existing body of literature by specifically addressing the gender differences in the impact of online reviews on perceived attractiveness of hotel. While previous studies have examined the influence of online reviews on consumer behaviors and decision-making, the explicit focus on gender as a moderating factor offers novel insights. This study not only adds to our understanding of the psychological mechanisms underlying the processing of online reviews but also provides practical implications for marketers and hotel managers in crafting gender-sensitive strategies.
Esophageal cancer global burden profiles, trends, and contributors
Authors: Teng Yi , Xia Changfa , Cao Maomao , Yang Fan , Yan Xinxin , He Siyi , Cao Mengdi , Zhang Shaoli , Li Qianru , Tan Nuopei , Wang Jiachen , Chen Wanqing
Published: July 2024

Objective: This study aimed to provide a comprehensive overview of the global burden of esophageal cancer (EC) and determine the temporal trends and factors influencing changes in the global burden. Methods: The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022. The mortality and disability-adjusted life years (DALYs) rates for EC from 1990–2019 were sourced from the 2019 Global Burden of Diseases. Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model. The trends in age-related EC burden were assessed using a decomposition approach. Results: An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide. Approximately 75% of cases and deaths occurred in Asia. Nearly 50% of global EC deaths and DALYs were attributed to tobacco use in men in 2019, while 20% were attributed to high body mass index (BMI) in women. From 1990–2019, EC deaths and DALYs attributable to almost all risk factors had declining trends, while EC deaths and DALYs attributed to high BMI in men had upward trends. The age-related EC burden exhibited an upward trend driven by population growth and aging, which contributed to 307.4 thousand deaths and 7.2 million DALYs due to EC. Conclusions: The EC burden remains substantial worldwide. Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC. Population growth and aging pose challenges for EC prevention and control efforts.
Kajian Strategi Desain Terminal Bus Berkelanjutan Studi Kasus Terminal Induk di Kota Bekasi
Authors: Yasin Affan Maulana , Yuliani Sri
Published: July 2024

Urban transportation is experiencing rapid growth in line with the increasing population, particularly in cities like Bekasi. Despite advancements in transportation modes in Bekasi, the Bekasi City Bus Terminal, classified as a Type A passenger terminal, still struggles to meet the mobility needs of its residents. The terminal faces various challenges, including traffic congestion, insufficient security and comfort in circulation, limited supporting facilities, poor services, and high environmental pollution levels. Therefore, this research aims to propose a redesign for the Bekasi City Bus Terminal, incorporating sustainable architectural principles. The research methodology involves a theoretical review using content analysis. The study results emphasize the necessity for design criteria that facilitate efficient circulation, transition spaces, and economic functionality in the bus terminal. Consideration of environmental conservation principles and building energy efficiency is crucial in this redesign process.
Implementasi Konsep Arsitektur Berkelanjutan pada Ruang Publik di Kabupaten Purworejo
Authors: Sari Maya Puspita , Yuliani Sri
Published: July 2024

The SDGs discuss the need for public spaces in the 11th component, namely the provision of public spaces and green open spaces that are safe, inclusive and easily accessible, especially for women and children, the elderly and people with disabilities. This encourages the planning of a public space in Purworejo Regency which is also in line with the development objectives of Purworejo Regency in the Regional Regulation of Purworejo Regency Number 11 of 2021. This research focuses on identifying and determining design strategies for public spaces with sustainable concepts. The method of theoretical studies with comparative analysis to determine the program and site of public spaces with sustainable concepts, then draw conclusions that produce design strategies. The result of this research is a design strategy for the implementation of sustainable concepts in public spaces in Purworejo Regency.
Analisis Ekspresi Kekuasaan dalam Kantor Desa Replika Istana Kepresidenan di Jawa Timur
Authors: Audina Shafira Zulfa , Soemardiono Bambang , Faqih Muhammad
Published: July 2024

Architectural activities of rural communities in Indonesia are closely related to local culture and traditions. As part of folk architecture, this activity has led to the phenomenon of village offices replicating the Presidential Palace. This research explores the intentions of the designers of Dadapan Village Office and Kemuningsari Kidul Village Office as replicas of the Presidential Palace to find out the expression of power that they want to communicate. This research uses qualitative methods with the tactics of field observation, in-depth interviews, and literature studies. Dadapan Village Office located in Pacitan Regency has a more complex expression of power than Kemuningsari Kidul Village Office located in Jember Regency. The expression of power intended by the designer of the village office includes the desire to form an identity; as a symbol of splendor; a symbol of wealth; a symbol of authority; a symbol of pride; and a symbol of a community protector.
Persepsi dan Preferensi Konsumen terhadap Penggunaan Material Bangunan Berbasis Limbah
Authors: Dewantara Frisgian , Rijaluddin Rijaluddin , Andayani Firda Rasyidian , Tambunan Lily , Larasati Dewi
Published: July 2024

Environmental challenges stemming from the escalating volume of waste necessitate innovative solutions, one of which involves utilizing waste as a raw material for building materials. However, prevailing research in this domain has predominantly concentrated on their characteristics/performances, with a notable dearth in discussions pertaining to consumer-centric aspects. The objective of this research is to examine public responses, comprehension levels, and considerations associated with the utilization of waste-derived materials. Therefore, the development of waste-derived materials can be facilitated towards mass production. Employing qualitative research methods, this research unveils misconceptions surrounding waste-derived materials, as well as the readiness and the consideration aspects, such as material characteristic/performance, sustainability, economic factors, aesthetics, functionality, availability, and knowledge. The findings are anticipated to contribute insights for decision-making processes, policy formulation, and industrial practices, fostering the informed integration of waste-derived materials in the construction and related sectors.
Implementasi Konsep Michi-no-eki pada Strategi Desain Anjungan Jalan sebagai Pendukung Business Branding
Authors: Firdaus Kartika Tiffania Fairuza , Wahyuwibowo Agung Kumoro
Published: July 2024

The concept of michi-no-eki has become a pilot study in several countries, such as Kenya and China, due to having been proven to be able to overcome the issue of inequality in areas crossed by roads. This research intends to analyze the implementation of the michi-no-eki concept on a road platform model in Kulon Progo Regency as a support for business branding. The method used is a comparative case study in Michi-no-eki in Japan to determine the basic considerations that can be implemented in the road platform design strategy in Kulon Progo Regency. The research results explain the recommendations for road platform models in Kulon Progo as supporting business branding, namely 1) located on National Road 3; 2) Has a rest function for road users with additional worship facilities; providing tourism information for road users and health facilities for local communities, and training facilities as well as direct selling depots for superior local products; 3) Accommodate the development of the community of artists, farmers and MSMEs; 4) Promote local agricultural products and processed products; and 5) implementing building architectural prototypes according to Kulon Progo Regent Regulation No. 87 of 2018 concerning Building Architectural Prototypes with Typical Kulon Progo Characteristics.
Optimization of Distance Between Check-In Area and Boarding Gates: Case Study of Terminal 3 of Soekarno-Hatta Airport
Authors: Khoiriyyah Jamilah Fauziana , Subiyantoro Heru
Published: July 2024

This research assesses the effect of the distance between Terminal 3’s check-in area and the boarding gate at Soekarno-Hatta Airport on passenger comfort. The focus is on how Terminal 3’s layout, which places a significant distance between these points, impacts passenger experience, satisfaction, and their preferred solutions. The study uses qualitative methods, observing Terminal 3 facilities and reviewing relevant literature. The expected outcomes include a deeper understanding of Terminal 3’s layout’s influence on passenger satisfaction and the identification of management and design factors that could mitigate this issue. The research considers passenger perspectives and preferences to provide recommendations for enhancing passenger accessibility and comfort in Terminal 3.
NLRP3 Inflammasome — a new universal target of asymptomatic hyperuricemia and gout management
Authors: Lebedev P. A. , Volova L. T. , Osina N. K. , Paranina E. V.
Published: July 2024

From modern perspective, hyperuricemia should be considered as a trigger of inflammatory activity in tissues and organs, leading to the formation of tophi, arthropathy, kidneys and cardiovascular system damage. Similarly, hypercholesterolemia, a proven factor in atherogenesis-far from all patients leads to the development of relevant clinical events. This commonality may be explained by the involvement of universal inflammatory mechanism. The key mediator of gout attacks is recognized as IL-1β, a product of NLRP3 (NLR family pyrin domain containing 3) inflammasome activation (complex multiprotein), responsible for local inflammatory response in synovial membrane and periarticular tissues with participation of macrophages and neutrophils. NLRP3 inflammasome activation is carried out by uric acid crystals, cholesterol exclusively after priming by lipopolysaccharides, peroxidation products and other damage factors associated with aging and comorbid conditions typical for gout and cardiovascular diseases. In addition, NLRP3 inflammasome activity is genetically determined and determines the frequency of these conditions. The discussed mechanism explains why the impact on factors associated with comorbidity is able to reduce the frequency of gout attacks along with cardiovascular outcomes. New clinically relevant pleotorpic effects of statins, sodium-glucose cotransporter-2 inhibitors, which have advantages over urates-lowering therapy in patients with asymptomatic hyperuricemia and can modify the course of gout, are demonstrated. Their anti-inflammatory properties, cardio and renoprotective effects, and tolerability advantages are emphasized. Blocking the activity of inflammasome is considered as a new universal therapeutic target for rheumatology and cardiology.
BRASH syndrome: а clinical case
Authors: Shalaeva D. D. , Pereverzeva K. G. , Fomina O. A. , Yakushin S. S.
Published: July 2024

The article describes a clinical case of BRASH syndrome in patient M., born in 1938, suffering from hypertension and diabetes mellitus. The patient took bisoprolol, eplerenone, azilsartan medoxomil, lercanidipine hydrochloride daily. She was admitted to the hospital complaining of weakness, eyes darkening, nausea, short-term loss of consciousness, rare pulse, diarrhea the day before. During the examination, she was diagnosed with severe sinus bradycardia (38 beats/min) and transient first-degree atrioventricular (AV) block, stage 4 chronic kidney disease of with hyperkalemia (potassium 5.53-6.12 mmol/l). Pulse-reducing drugs, blockers of the renin-angiotensin-aldosterone system were canceled for the patient, 0.9% sodium chloride solution and furosemide were prescribed. The patient was discharged in a satisfactory condition. This clinical example meets the criteria of BRASH syndrome, since against the background of taking an AV node blocker in a small dose, a patient with chronic kidney disease with mild to moderate hyperkalemia developed severe sinus bradycardia and transient grade 1 AV block. The trigger factors for BRASH syndrome development of were azilsartan medoxomil and eplerenone intake, as well as hypovolemia due to diarrhea.
Student’s Perception Towards the Use of DeepL Translator in Writing Thesis or Journal for English Education Students
Authors: Asmara Devi Sunita Mutia , Kembaren Farida Repelitawati Br
Published: July 2024

Translation is a crucial aspect for non-native English students, especially when writing academic theses or journals. This study aims to discuss the use of the DeepL Translator application in writing a thesis or journal of English students. This research employs qualitative methods with a case analysis design by analyzing data derived from questionnaire data and deeper interviews related to the use of DeepL Translator. The use of questionnaire data and further interviews were conducted with 24 final semester English students. The data were analyzed using Miles and Huberman's techniques, which include data reduction, data presentation, data display, and drawing conclusions to evaluate the effectiveness of the DeepL Translator. The results of this study show that students use DeepL translators a lot when making their theses or journals. By using the method of translating per paragraph, students complete their thesis or journal using DeepL Translator to convert Indonesian into English. The reason they use this application is because the results of this translation are more accurate and effective than those of other translation machines and also the students agree that they are often use this DeepL Translator to write their thesis or journal.
Developing an English Course Teaching Plan for a Semester from the Task-Based Language Teaching (TBLT) for the Mathematics Department Students at Zainul Hasan Islamic University of Probolinggo
Authors: Zainuddin  , Hamdani Beny
Published: July 2024

The development of a Teaching Plan for a Semester (TPS) is directly related to the analysis of competency standards, teaching methods, and learning evaluation. Based on that, the specific targets to be achieved in this research include two things. The two objectives are (i) to formulate graduates' English learning outcomes based on needs analysis and objective analysis of input English proficiency and (ii) to design learning materials to meet the formulated learning outcomes. In general, the research method used is the development research method of Gall, Borg, Van den Akker, Gravemeijer, McKenney, and Nieven. Meanwhile, the approach used in this study is a combination of the ADDIE approach from Branch and the systems approach from Dick and Carey. The results of the study show that the level of English language needs indicated by stakeholders must be adapted. This adaptation is based on input competencies that do not meet the standards to be put into the ESP stage purely. Therefore, the design of the ESP lesson plan is still carried out by considering matters related to the input of general English competence.
Size spectra in freshwater streams are consistent across temperature and resource supply
Authors: Gjoni Vojsava , Pomeranz Justin , Junker James , Wesner Jeff
Published: July 2024

Biological communities can be described using the individual size distribution (ISD), a remarkably consistent negative relationship between individual mass and abundance that can be described as a power law (N ~ Mλ). The parameter λ denotes the rate of decline in relative abundance from small to large individuals. Despite well-known influences of temperature on λ, interactive effects of temperature and resource supply on λ remain poorly understood. Leveraging data from 2.4 million individual body sizes in freshwater stream food webs, we test the hypothesis that λ varies as a function of temperature and resource supply. Surprisingly, despite varied environmental conditions and complete species turnover, there was no discernible impact on λ from temperature or resource supply. Instead, λ was consistently ~ -1.2 (sd = 0.04), differing from predictions of metabolic scaling theory, which assumes a value close to -2. This implies substantial subsidy inputs to large predators along with metabolic scaling coefficients shallower than assumed by the ¾ power law. Using simulations and mesocosm experiments, we provide support for a metabolic scaling coefficient of approximately ~0.4 for freshwater streams, along with a consistent influence of subsidies. The findings underscore remarkable consistency of individual size distributions in freshwater streams, likely driven by shallow metabolic scaling and large subsidies to large consumers.
Post-Traumatic Reactions and Quality of Life after Pelvic Exenteration for Gynecologic Cancer: A Retrospective Cohort Study
Authors: Thompson Lora M.A. , Loecher Nele , Albizu-Jacob Alexandra , Chon Hye Sook , Wenham Robert M. , Donovan Kristine A.
Published: July 2024

Objective: We examined post-traumatic reactions and quality of life in women with recurrent gynecologic cancer who underwent a pelvic exenteration (PE), a rare, potentially life-saving radical surgery associated with life-altering sequalae.
Methods: Twenty-one women who had completed PE at least 6 months prior completed measures of post-traumatic stress, post-traumatic growth, depression, and quality of life. Quality of life scores were compared to normative values for the general and gynecologic cancer populations.
Results: Thirty percent of women reported clinically significant post-traumatic stress symptoms and 71% endorsed clinically significant depressive symptoms. More post-traumatic stress was associated with less post-traumatic growth, more depressive symptoms, and worse quality of life. In general, women’s quality of life was worse than the general population but comparable to women with stage III-IV ovarian cancer and women with cervical cancer. Social functioning was markedly lower in our sample and women reported more pain, diarrhea, and financial difficulties post-PE compared to published norms. There were no differences in quality of life based on age, type of PE, or cancer type.
Conclusions: Findings support long-term continued symptom management and the ongoing rehabilitation of patients to optimize physical, psychological, and social well-being in PE survivorship.
Perceptions of pre-service teachers on the use of ChatGPT during their training and the future implications for their future role in high schools: A research in progress
Authors: Pesce Maura Amaranti , Blanco Daniel Fernández
Published: July 2024

The reception of ChatGPT in the educational field has varied between enthusiasm and scepticism, generating a series of controversies and challenges in response to the emergence of artificial intelligence (AI) technologies within the educational context. The purpose of this study was to interpret and describe the perceptions of a group of pre-service teachers on the use of ChatGPT as an assistant in a learning experience implemented during their training, and on the implications of this AI tool in their future work context as teachers. A sequential mixed methodology was employed, initially collecting quantitative data, followed by a deeper analysis based on qualitative data from which explanatory categories of the phenomenon emerged. Our study on the integration of ChatGPT into teacher training programs reveals that students valued the use of ChatGPT for its conceptual support and quick feedback, enhancing their learning experience. However, concerns about the accuracy of information and plagiarism underline the need for a critical engagement with AI tools. Regarding their future teaching role, they highlighted the importance of mediation, training, and guiding students in the critical and responsible use of AI. They also identified the need to modify assessment methods to encourage critical thinking, problem-solving, and creativity. The study emphasized the importance of integrating AI technologies into teacher training in a reflective and critical manner, with guidance from educators and IT specialists. This These findings suggest a balanced approach to incorporating AI in education, emphasizing ethical use and the transformative potential of AI to support pedagogical objectives.
ERBVS: Enhanced Retinal Blood Vessel Segmentation using Multiple Modalities and Attention Mechanisms with Adversarial Training and Ensemble Deep Learning Operations
Authors: Thool Komal Umare
Published: July 2024

It would, therefore, require highly advanced prediction tools to enhance early diagnosis and preemptive mechanisms for all these burgeoning diseases. Fast and correct disease prediction and pre-emption have huge potential for changing clinical outcome and ensuring timely and effective interventions that reduce morbidity and mortality. Current predictive models, instrumental as they are, have been found faltering in precision, recall, accuracy, and timeliness. Such delays and inaccuracies often miss the therapeutic window or lead to misguided clinical decisions. In this work, we present a novel model that aims to quite dramatically improve the process of segmentation and classification. Our approach embeds Attention Mechanisms with Adversarial Training and Ensemble Deep Learning Operations, together with a multimodal approach, which places it substantially higher across several metrics. This improves the precision, accuracy, recall, and AUC by 8.5%, 8.3%, 4.9%, and 3.9%, respectively, for segmentation and classification, while reducing the classification delay by 5.9% in different situations. Not only does our model handle the intrinsic limitations of current methods, but it also shows flexibility for a wide range of clinical applications. The compelling improvements in classification and preemption metrics strengthen its potential to make a sea change in the disease prediction framework for establishing optimum patient outcomes and efficient scenarios of healthcare delivery.
Bioengineering stabilization of marginal soil at the sloping face of the embankment using the vetiver root system
Authors: Jandyal Taran , Shah Mohammad Yousuf
Published: July 2024

To combat erosion and prevent shallow slope collapses, soil bioengineering amalgamates biological, mechanical, and ecological principles, primarily aimed at safeguarding highland slopes. Historically, wood and live plants have been the primary materials employed for stabilizing hills and slopes over millennia. The imperative for leveraging vegetation to restore slope stability is particularly pronounced, addressing soil erosion and shallow slope failures in both natural and human-altered environments. Recognized widely, planting or preserving vegetation in erosion-prone areas stands as a highly effective strategy for soil erosion control. Even in semi-arid regions where above-ground biomass may temporarily diminish, the enduring underground roots play a pivotal role in safeguarding the topsoil from erosion. The strength required to dislodge the root system of each grass vertically from the soil serves as an indicator of soil binding capacity. Prior to recommending suitable treatments, a comprehensive assessment encompassing various factors such as current vegetation cover, hydrology, slope aspect, angle, soil composition, and geological characteristics is imperative. This study employs vetiver grass to fortify soil and utilizes GEO5 software for slope analysis. The aim of experimenting with vetiver as a bioengineering solution is to ascertain its efficacy either as a substitute for or complement to traditional engineering approaches for slope and erosion challenges. Analysis conducted on an unreinforced soil location using GEO5 software revealed a factor of safety (FOS) of less than 1.5, indicating an unstable slope. Conversely, when the same location was reinforced with vetiver root and analysed using the same software, the FOS exceeded 1.5, signifying a stable slope. Finally, recommendations for future research endeavours are delineated.
Anxiety and depression is common in individuals living with a rare disease: exploring the impact of pain and physical activity in UK Biobank data
Authors: Hill Claire , Shah Sonum , Crowe Ashleen , McKnight Amy Jayne
Published: July 2024

Background
Whilst individually rare, affecting less than 1 in 2,000 people, together rare diseases (RDs) affect an estimated 475 million people globally, including 4 million people within the UK. RDs are often associated with unmet care needs, which can impact both physical and mental health.
Harnessing the UK Biobank, health and wellbeing data from 502,401 individuals over the age of 40 was assessed. Using the Orphanet database for rare diseases and International Classification of Diseases Codes 10 (ICD10) from the UK Biobank, participants were classified as having no diagnosis, non-rare diagnoses only, or a rare diagnosis with or without comorbidities.
Results
Mental health, pain, physical wellbeing, and comorbidity measures were compared between these three groups. Depression and anxiety was significantly more common in those living with a rare disease (67% and 65%, respectively) compared to non-rare diagnoses (NRD) (p < 4x10-7). Depression and anxiety was more common in females compared to males across all groups (p < 0.009). Individuals living with a RD experienced significantly more general pain (p < 3x10-28), and reported significantly reduced physical activity (p < 3x10-44), compared to NRD. A higher proportion of individuals living with a RD also presented a higher comorbidity burden, when compared to individuals living with NRD (NRD: Median number of comorbidities = 5, IQR = 3-10, RD: Median number of comorbidities = 17, IQR = 10-29).
Conclusion
This study reveals a significant burden of disease diagnosis, which is further exacerbated by a rare disease diagnosis. This work highlights the need for novel support mechanisms to target the specific needs of patients living with a RD, with careful consideration of gender-specific influences.
Effectiveness of a Multi-component Sleep-Mood Group Intervention on Improving Insomnia in University Students – a Pilot Randomized Controlled Trial
Authors: Pape Laura M. , Jonker Sophie , Kivelä Liia M.M. , Straten Annemieke van , Antypa Niki
Published: July 2024

Background: Sleep and mental health problems are very common in university students. The objective of this study was to assess the effectiveness of a multi-component sleep-mood intervention on improving sleep and mental health in university students with clinically significant insomnia symptoms, and to investigate possible mediators.
Methods: Thirty-five participants were randomized to the Sleep Mood Intervention: Live Effectively (SMILE) intervention (n= 23), or wait-list group (n= 12). SMILE is a multi-component group therapy and includes elements of cognitive behavioral therapy for insomnia (CBT-I), mindfulness, and lifestyle modifications, in four weekly two-hour sessions. The primary outcome was insomnia severity. Secondary outcomes were severity of depression and anxiety, and quality of life (QoL). Dysfunctional beliefs and attitudes about sleep and pre-sleep arousal were assessed as mediators.
Results:Intention-to-treat analysis showed significant time x treatment interaction on insomnia symptoms (p=.021, partial η²=.152), with significantly lower insomnia severity for SMILE compared to waitlist at post-test. No significant effects were found on depression, anxiety, and QoL. Dysfunctional beliefs mediated the effect on insomnia severity, but pre-sleep arousal did not.
Conclusions: This integrated group intervention is associated with reductions in insomnia symptoms in university students. Since no significant effects were detected on mood and QoL, future studies with larger sample size may explore the effects of this intervention on these outcomes.
Trial Registration:
Registry: Overzicht van Medisch-wetenschappelijk Onderzoek
Registration number: NL-OMON46359
Date of registration: September 18th, 2018