bluuebunny/crossref_metadata_2025 huggingface dataset:
Concentration of phytosterols for analysis by supercritical fluid extraction
Authors: Snyder Janet M. , King Jerry W. , Taylor Scott L. , Neese Angela L.
Published: June 2007

Fractionation of sterols from plant lipid mixtures was accomplished using a multistep supercritical fluid extraction (SFE) procedure. Samples of seed oils, margarine, corn germ oil, and corn fiber oil were extracted to yield enriched phytosterol fractions. Supercritical fluid chromatography (SFC) was utilized to separate and determine the concentration of the plant sterols in the extracts from the various samples. The sterol concentration in the original samples varied from 2.2 mg/g in soybean oil to 13.2 mg/g in oil extracted from corn fiber. After the SFE‐based fractionation of the samples, the sterol concentration was increased to 64.4 mg/g in the extract from soybean oil and 166.2 mg/g in the extract from corn fiber oil. Oil extracted from corn bran, which measured 8.6 mg/g in the original oil, increased to 322.2 mg/g using the fractionation process. The benign conditions utilized by SFE and SFC proved to be effective for the analyses of these compounds without inducing degradation of the analytes.
Preparation of conjugated linoleic acid from safflower oil
Authors: Ma David W. L. , Wierzbicki Antoni A. , Field Catherine J. , Clandinin Michael T.
Published: June 2007

Synthetically prepared mixtures of conjugated linoleic acid (CLA) are widely used in animal and cell culture studies to investigate the potential effects of the Δ9c, 11t‐18:2 isomer found in food products from ruminant animals. Alkali isomerization of linoleic acid is a common method used in the synthesis of a mixture of CLA isomers containing predominantly the Δ9c, 11t‐18:2 and Δ10t, 12c‐18:2 isomers. Some biological activity might also be mediated by the Δ10t, 12c‐18:2 isomer. Currently few published methodologies exist describing procedures for the enrichment of these two isomers. A method is described herein to take advantage of an inexpensive oil, safflower oil, for use in synthesis of CLA and a procedure to enrich the Δ10t, 12c‐18:2 isomer.
Palm olein quality parameter changes during industrial production of potato chips
Authors: du Plessis L. M. , Meredith A. J.
Published: June 2007

New legislation introduced in South Africa for the quality of used frying oils has resulted in the need to identify quicker, more suitable methods that correlate well with results from two official methods, namely, total polymerized glycerides and total polar components. Oil and product samples were taken at regular intervals during a commercial frying process in palm olein. Oil samples were analyzed for a number of different quality parameters viz. tocopherol content, dielectric constant, total polymerized glycerides, total polar components, tertiary butylhydroquinone (TBHQ) content, anisidine value, Rancimat induction period, and free fatty acid content, and the results statistically compared to results from official methods. Oil was expressed from product stored under accelerated conditions and analyzed for the same quality parameters. Fried product was also subjected to sensory evaluation to measure the degree of oil deterioration and sensory preference. The frying trial was successfully executed with refined, bleached, and deodorized palm olein and the frying oil used to a free fatty acid (FFA) content of 0.41%. Oil and product sampling were done at different FFA value levels. Frying oil quality was verified at the onset of the trial and at regular intervals. The frying oil total polar component value increased to approximately half of the limit set by the official regulation. This point was reached mainly due to the high starting value of the fresh oil. Frying oil total polymerized glycerides increased from below 1% to 2.1%. This increase is negligible when compared to the general trend for polyunsaturated oils. The alternative laboratory methods used for predicting oil quality can be rated as follows: total tocopherol content >dielectric constant >FFA >TBHQ content >anisidine value >Rancimat induction period. The first three methods correlated well with total polar component levels and it is recommended that the dielectric constant and FFA measurements be applied for monitoring oil condition during frying. It is possible that viscosity changes could be used for the monitoring of polyunsaturated frying oils. Evaluation of oil extracted from product revealed a negligible effect of non‐oil components on oil quality parameters. The same was observed when product was stored at −10°C and at 37°C.
Determination of optimal conditions for selected adsorbent combinations to recover used frying oils
Authors: Lin Song , Akoh Casimir C. , Reynolds A. Estes
Published: June 2007

The treatment of frying oils with adsorbents could practically extend the frying life of oils. Combined synthetic adsorbent treatment of used frying oils was studied the first time. The combinations of four commonly used filter aids: Britesorb (Br), Hubersorb 600 (HB), Frypowder (Fr), and Magnesol (Ma) were evaluated for frying oil recovery. AOCS official methods were used to evaluate their adsorptiveness, including free fatty acids (FFA), conjugated diene value, total polar components, oxidative stability index (OSI), and absorbance at 420 nm. The selected combinations HB+Ma+Fr and HB+Ma+Br exhibited consistent high recovery abilities on various used oil samples. A 3, 3, and 2% HB, Ma, and Fr, respectively, for the first combination (F), and 2, 3, and 2% HB, Ma, and Br, respectively, for the second combination (B) were the most effective. The optimal treatment duration was 6–9 min and 3–6 min for combinations F and B, respectively, which reduced FFA by 82.6–87.6%, absorbance by 26.8–32.6%, and Foodoil Sensor readings by 5.6–8.6%. Addition of antioxidant, such as 50 ppm butylated hydroxytoluene and 50 ppm propyl gallate, increased the OSI value by 48.9–80.8%. Such adsorbent combinations may be used in practical operation to extend frying life of frying oils and improve the healthy aspects of used frying oils.
Theoretical methods used in elucidating activity differences of phenolic antioxidants
Authors: Zhang Hong‐Yu
Published: June 2007

The effectiveness of the existing theoretical methods used in prediction of antioxidant activity, including structure‐activity relationships (SAR) and theoretical index, were evaluated. In most cases, it was found that the theoretical predictions were consistent with the experimental data. Although only one mechanism, free radical scavenging, was considered in the theories, the methods were valuable in predicting the activity of antioxidants to protect lipid oxidation.
Structural changes of sinapic acid during alkali‐induced air oxidation and the development of colored substances
Authors: Cai R. , Arntfield S. D. , Charlton J. L.
Published: June 2007

Structural changes of sinapic acid were induced by air oxidation in aqueous solutions at pH 7–10 and followed by spectral and high‐performance liquid chromatographic (HPLC) analysis. Color properties of the sinapic acid solutions were determined by taking the transmittance spectra, calculating the Commission Internationale de l’Eclairage (CIE) 1931 tristimulus values, and converting to Hunter L a b values. Reaction rate constants for sinapic acid were determined by a kinetic study based on the quantitative results from HPLC analysis. These reactions were first order with respect to sinapic acid and fit the appropriate equation with a coefficient of R2 >0.97. Sinapic acid was converted to thomasidioic acid with reaction rate constants (k) of 8.54×10−6, 2.51×10−5, and 4.87×10−5 s−1 in phosphate‐boric acid buffers of pH 7, 8.5, and 10, respectively. Similar reactions in ammonium bicarbonate buffers were more than 10 times faster. With time, thomasidioic acid further converted to 2,6‐dimethoxy‐p‐benzoquinone and 6‐hydroxy‐5,7‐dimethoxy‐2‐naphthoic acid. Air oxidation of sinapic acid aqueous solutions caused darkening of the color for the system, with the 2,6‐dimethoxy‐p‐benzoquinone as a major color contributor.
Constraints on multiple center-embedding of clauses
Authors: KARLSSON FRED
Published: June 2007

A common view in theoretical syntax and computational linguistics holds that there are no grammatical restrictions on multiple center-embedding of clauses. Syntax would thus be characterized by unbounded recursion. An analysis of 119 genuine multiple clausal center-embeddings from seven ‘Standard Average European’ languages (English, Finnish, French, German, Latin, Swedish, Danish) uncovers usage-based regularities, constraints, that run counter to these and several other widely held views, such as that any type of multiple self-embedding (of the same clause type) would be possible, or that self-embedding would be more complex than multiple center-embedding of different clause types. The maximal degree of center-embedding in written language is three. In spoken language, multiple center-embedding is practically absent. Typical center-embeddings of any degree involve relative clauses specifying the referent of the subject NP of the superordinate clause. Only postmodifying clauses, especially relative clauses and that-clauses acting as noun complements, allow central self-embedding. Double relativization of objects (The rat the cat the dog chased killed ate the malt) does not occur. These corpus-based ‘soft constraints’ suggest that full-blown recursion creating multiple clausal center-embedding is not a central design feature of language in use. Multiple center-embedding emerged with the advent of written language, with Aristotle, Cicero, and Livy in the Greek and Latin stylistic tradition of ‘periodic’ sentence composition.
Machine learning theory and practice as a source of insightinto universal grammar
Authors: LAPPIN SHALOM , SHIEBER STUART M.
Published: June 2007

In this paper, we explore the possibility that machine learning approaches to natural-language processing being developed in engineering-oriented computational linguistics may be able to provide specific scientific insights into the nature of human language. We argue that, in principle, machine learning results could inform basic debates about language, in one area at least, and that in practice, existing results may offer initial tentative support for this prospect. Further, results from computational learning theory can inform arguments carried on within linguistic theory as well.
The schistosome in the mammalian host: understanding the mechanisms of adaptation
Authors: KUSEL J. R. , AL-ADHAMI B. H. , DOENHOFF M. J.
Published: June 2007

In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs of the parasite, with host fluids and cells. The surface and secretions of the schistosome egg have very different properties from those of other parasite stages, but adapted for the dispersal of the eggs and for the preservation of host liver function. We draw from studies of mammalian cells and other organisms to indicate how further work might be carried out on the signalling function of the surface glycocalyx, the raft structure of the surface and existence of pores in the surface membrane, the repair of the surface membrane, the role of the membrane structure in ion channel function (including recent work on the actin cytoskeleton and calcium channels) and the possible role of P-glycoproteins in the adaptation of the parasite to its environment. We are speculative in some areas, such as the suggestions that variability in surface properties of schistosomes may relate to the existence of membrane rafts and that parasite communities may exhibit quorum sensing. This speculative approach is adopted with the hope that future work on the whole organisms and their interactions will be encouraged.
Did Wittgenstein Speak with the Vulgar or Think with the Learned? Or Did He do Both?
Authors: Cook John W.
Published: June 2007

Wittgenstein has often been criticized, and even dismissed, for being a patron of ordinary language, a champion of the vernacular, a defender of the status quo. One critic has written: ‘When Wittgenstein set up the actual use of language as a standard, that was equivalent to accepting a certain set up of culture and belief as a standard … It is lucky no such philosophy was thought of until recently or we should still be under the sway of witch doctors …’ In what follows I want to show just how wide of the mark criticisms of this sort are.
The Trojan Horse of the Scottish Philosophy
Authors: Somerville James
Published: June 2007

James McCosh considered his product of ‘a labor of love’, The Scottish Philosophy, Biographical, Expository, Critical, From Hutcheson To Hamilton to fall within ‘what may be regarded as a new department of science, the history of thought’. The value of the book lies, therefore, in not just its outlines of works of philosophers of the period with the views afforded of the academic life most of them led; but its sense—albeit unsure—that ‘the Scottish school of philosophy’ (1) after its rise evolved into something less distinctive, more commonplace philosophically. McCosh could not admit that the school had declined. Noting the change, he barely hints at why it happened. The explanation, it will be argued, involves the central place assigned to belief in the doctrines of the school, so is of current interest given the undue prominence belief continues to be accorded by philosophers.
But is it Art? A new look at the institutional theory of art
Authors: Skidelsky Edward
Published: June 2007

In 1973, the philosopher George Dickie proposed an ingenious new answer to the old question: what is art? Arthood, he suggested, is not an intrinsic property of objects, but a status conferred upon them by the institutions of the art world. He accordingly attached an exemplary significance to works like Duchamp's urinal, whose very lack of intrinsic distinction focuses our attention upon their institutional context. But his theory was about art in general, and not just readymades. ‘I am not claiming that Duchamp and his friends invented the conferring of the status of art; they simply used an existing institutional device in an unusual way.’
Some Problems with Virtue Theory
Authors: Everitt Nicholas
Published: June 2007

Virtue ethics (VE for short) is currently so widely embraced that different versions of the theory can now be distinguished. Some of these are mapped out in Statman's useful introduction to his collection. There are enough of these versions to constitute a family, and consequently what they share is a family resemblance rather than agreement to a defining set of necessary and sufficient conditions. What I propose to do, therefore, is to criticise one of the main versions of VE. Rosalind Hursthouse is the main proponent of the version which I will criticise. I choose her as a spokesperson, not because her version of VE is especially weak. On the contrary, it is because she is one of the leading protagonists of VE, and because her writings provide a lucid, powerful and elegant exposition of VE that her version of the theory is an appropriate object of scrutiny.
Descartes, Plato and the Cave
Authors: Buckle Stephen
Published: June 2007

It has been a commonplace, embodied in philosophy curricula the world over, to think of Descartes' philosophy as he seems to present it: as a radical break with the past, as inaugurating a new philosophical problematic centred on epistemology and on a radical dualism of mind and body. In several ways, however, recent scholarship has undermined the simplicity of this picture. It has, for example, shown the considerable degree of literary artifice in Descartes' central works, and thereby brought out the deceptive character of his self-presentation there. In particular, it has revealed the extent of his debts to the Neoplatonist tradition, particularly to Augustine, and of his engagement with the Scholastic commentators of his day. My aim in this paper is to push this interpretative tendency a step further, by bringing out Descartes' indebtedness to Plato. I begin by offering some reminders of the broadly Platonic nature of Cartesian dualism. I then argue that he provides clues sufficient for—and designed to encourage—reading the Meditations on First Philosophy in the light of distinctively Platonic doctrines, and in particular, as a rewriting of the Platonic allegory of the cave for modern times. It will further be argued that some puzzles about the Discourse on the Method can be resolved by recognizing that Descartes there presents himself as a Socratic enquirer after truth. I conclude by drawing attention to some practical benefits that flow from recognizing these linkages.
The Secret of Tristan and Isolde
Authors: Magee Bryan
Published: June 2007

In his autobiography, Mein Leben, Wagner tells us that it was partly his reading of Schopenhauer's The World as Will and Representation (Die Welt als Wille und Vorstellung), and the need to give ‘rapturous expression’ to the ‘frame of mind produced’ by that reading, that gave him the initial conception of Tristan and Isolde.
How to live?
Authors: Shand John
Published: June 2007

This paper is not about truth but about consistency. Pointing to inconsistency would be a dry worthless exercise were there not people who are inconsistent in the specific way described and for whom such inconsistency matters. There are those who tell us that life has no value and is pointless, that it is ‘absurd’, and yet that it matters how we live our lives; in particular that we ought to square up to the truth that life has no value and is pointless. Philosophy and art, especially in the nineteenth and twentieth centuries, have often seen this view in the ascendant when they get onto the issue of ‘the meaning of life’.
Life trajectories and burden of adversity: mapping the developmental profiles of suicide mortality
Authors: SÉGUIN MONIQUE , LESAGE ALAIN , TURECKI GUSTAVO , BOUCHARD MÉLANIE , CHAWKY NADIA , TREMBLAY NANCY , DAIGLE FRANCE , GUY ANDRÉE
Published: June 2007

Background

Little is known about differential suicide profiles across the life trajectory. This study introduces the life-course method in suicide research with the aim of refining the longitudinal and cumulative assessment of psychosocial factors by quantifying accumulation of burden over time in order to delineate distinctive pathways of completed suicide.

Method

The psychological autopsy method was used to obtain third-party information on consecutive suicides. Life-history calendar analysis served to arrive at an adversity score per 5-year segment that was then cluster-analysed and correlated to define victim profiles.

Results

Two distinct life trajectories emerged: (1) individuals who experienced childhood traumas, developmental adversity and little protection were more likely to present concurrent psychiatric and Axis II disorders; and (2) individuals who experienced less adversity but seemed more reactive to later major difficulties.

Conclusions

The life calendar approach presented here in suicide research adds to the identification of life events, distal and recent, previously associated with suicide. It also quantifies the burden of adversity over the life course, defining two distinct profiles that could benefit from distinct targeted preventive intervention.
Memorabilities: enduring relationships, memories and abilities in dementia
Authors: BASSETT RAEWYN , GRAHAM JANICE E.
Published: June 2007

This paper reports the findings of a one-year qualitative investigation of the memories and activities of people with mild to moderate Alzheimer's. We observed and interviewed 58 patient-carer dyads during home visits. The progression of the dementia symptoms was documented, and information was collected on social-relational events, as well as accounts of awareness, attention and anticipation, which are often neglected in research that focuses on the activities of daily living. The participants identified problems that were important to them; those with Alzheimer's disease were aware that they were not as attentive as they once had been, that they could no longer rely upon the memory of, or consciously recollect and relive, a past experience, and that the future was more difficult to anticipate. The participants' accounts describe relationships, memories and abilities – or ‘memor-abilities’ – of a past and their effects on their present and future. Our findings differ from clinical representations of memory located solely in the individual. Instead, memories are regarded as a synergistic package of both social and individual meanings that ‘leak’ between the two. What experimental psychologists interpret as systems and processes are played out in the everyday world of people with Alzheimer's disease as contextual, bounded and interdependent states of awareness, attention and anticipation. We maintain that memory is simultaneously individual and social, and that memorabilities are shared, co-constructed events and experiences in the past, present and future.
Orientation, opportunity and autonomy: why people work after state pension age in three areas of England
Authors: PARRY JANE , TAYLOR REBECCA F.
Published: June 2007

With the central players in the United Kingdom policy debate on pensions schemes and funding advocating an extension to the average working life (or, more precisely, a rise in the age of ceasing work), this paper reports the findings of qualitative interviews with men and women at or approaching state pension age that examined what motivated some people to continue to work after that age. By exploring their work histories and orientations to work, the paper shows that people from different social and occupational backgrounds not only conceive work and retirement in different ways but also have contrasting opportunities to continue in occupations after retirement age. Their attitudes and the opportunities they encounter shape the decisions they make at state pension age. Distinctions are drawn between those who articulated an identity as a ‘worker’ and those who defined themselves as ‘professionals and creatives’, and within those categories, between the employed and self-employed. The paper elucidates the tensions between individuals' normative expectations of retirement, their desire for autonomy and flexibility in later life, and the financial and occupational reality of life after state pension age. We argue that understanding the different cultural meanings of work and retirement for different types of worker has implications for the design and implementation of policies to extend working life.
Introduction
Authors: STÅHL KRISTINA HAGSTRÖM
Published: June 2007

In the past decade and a half, feminism and gender studies have undergone a process of critical self-scrutiny and re-assessment. Presently, the fields of theatre and performance studies are undertaking a similar project of self-evaluation, as evidenced by recent calls to assess the ‘state of the field’ as well as its future directions. Elaine Aston and Geraldine Harrison suggest in their recent co-edited volume, Feminist Futures? Theatre, Performance, Theory, that any attempt to envision the future must begin by examining the present, which in turn entails looking to, and reflecting on, the legacies and remains of the past. In her article for this issue of TRI, ‘A Critical Step to the Side: Performing the Loss of the Mother’, Aston does precisely this, asking, ‘in what ways it might be critically productive to come back to the maternal as a subject for feminism’.
Women in Greek Tragedy Today: A Reappraisal
Authors: WILMER STEVE
Published: June 2007

Reacting to the concerns expressed by Sue-Ellen Case and others that Greek tragedies were written by men and for men in a patriarchal society, and that the plays are misogynistic and should be ignored by feminists, this article considers how female directors and writers have continued to exploit characters such as Antigone, Medea, Clytemnestra and Electra to make a powerful statement about contemporary society.
The Masked Activist: Greek Strategies for the Streets
Authors: CASE SUE-ELLEN
Published: June 2007

Greek tragedy served as a disciplinary state apparatus that displaced women's public performances of the lament. Yet, in spite of its displacements and regulatory structures, the tragedy has been adopted by Euro-American playwrights and performers for political and even feminist political purposes. From Heiner Müller's Medeamaterial to readings of the comedy of Lysistrata, the structures of the Greek stage are currently deployed to stage the relation of gender to state practices. While these examples may seem to be in contradiction to the Greek structures, they actually further the use of the classical dramaturgical devices for their purposes within the tradition. However, certain Arabic revisions of Lysistrata reveal the assumptions in the model that prevent its adoption.
A Critical Step to the Side: Performing the Loss of the Mother
Authors: ASTON ELAINE
Published: June 2007

This essay sets out to ask in what ways it might be critically productive to come back to the maternal as a subject for feminism. Drawing on Eve Sedgwick's desire to ‘loosen’ the antiessentialist drive to get ‘beyond’ gender, and her consideration in this respect of a non-dualistic idea of ‘beside’, I locate my analysis in three performances, examined ‘beside’ each other. Each of these performances is a solo show: Anna Yen's Chinese Take Away (1997), SuAndi's The Story of M (1994) and Kazuko Hohki's Toothless (1998). Moreover, each solo is located in different inter-national, maternal geographies: Asian/Australian (Yen), black British (SuAndi) and Japanese/British (Hohki), and each performs the loss of the mother by the daughter. Working also with Judith Butler's proposal that grief and loss afford a political, transformative means of ‘becoming undone’, I ‘read’ these three international geographies of the maternal side by side as different from each other, but all connected to the critical project of rethinking the maternal.
Unveiling: Persepolis as Embodied Performance
Authors: WORTH JENNIFER
Published: June 2007

This paper examines Marjane Satrapi's graphic novels Persepolis 1 and Persepolis 2 as examples of unconventional solo performance, and argues that these personal narratives can be read as a type of embodied performance that might otherwise be denied Satrapi. The traditional novel is regarded as an outlet for women denied a public presence; the graphic novel goes a step further, allowing presence both vocally and physically through repeated self-portraiture, which deals frankly with distinctly corporeal issues of visibility, sexuality and identity. These are threaded through the narrative and dealt with frankly in both word and image. Drawing on comic and performance theory to discuss how Satrapi uses the interplay of visual and narrative languages to perform herself, I contend that graphic novels may best be understood as occupying a middle ground between the novel and the theatre, where their formal liminality frequently echoes the liminal states of their protagonists.
Gordon Craig, Mei Lanfang and the Chinese Theatre
Authors: TIAN MIN
Published: June 2007

Edward Gordon Craig's 1935 visit to Russia coincided with Mei Lanfang's 1935 performance in Russia. While Mei Lanfang's performance and its impact on Brecht and Russian theatre artists have been well documented and studied in recent years, Craig's contacts with the Chinese actor and his interest in the Chinese theatre, however, have yet to be investigated. Drawing on previously unpublished archive materials and other rarely used sources, this article for the first time documents Craig's contacts with Mei Lanfang during his visit to Russia. It also investigates his interest in the Chinese theatre in the context of his theoretical construction of the art of the theatre and his overall interest in the traditions of Asian theatres.
The Virtuoso's Stage: A Theatrical Topos
Authors: BRANDSTETTER GABRIELE
Published: June 2007

This essay considers the virtuoso in music, theatre and dance as a liminal figure of performativity. It draws on cultural studies as well as the history of science to offer a critical reading which follows the virtuoso's oscillation between science and art. The escalating dynamic in the virtuoso's technical control of material (of the body, the ‘instrument’, language) leads to a polarization between artistic ‘creation’ and virtuoso performance: the virtuoso thus occupies a seismographic function within the aesthetic debates of the nineteenth century. The article also outlines the relationship between the media and virtuoso performance and the relevance of the anecdote for the virtuoso's charismatic impact. This essay will contribute to our understanding of how the contemporary media influenced the virtuoso concept, and address the issue of whether the (partial) disappearance of the virtuoso from the theatre stage translocates the figure of the virtuoso onto other ‘cultural stages’.
Bone mineral density, polyphenols and caffeine: a reassessment
Authors: Dew T. P. , Day A. J. , Morgan M. R. A.
Published: June 2007

Several studies have shown beneficial associations between tea consumption and bone mineral density (BMD) and fracture risk. Current investigations into potential mechanisms of benefit are focused upon the F and polyphenol components of tea. However, previous studies have pointed towards caffeine consumption as a potential risk factor for low BMD and high fracture risk. Tea, therefore, represents an interesting paradox as a mildly caffeinated beverage that may enhance bone health. Fruit and vegetable intake has also been associated with BMD, and it is now apparent that several fruit and vegetable components, including polyphenols, may contribute positively to bone health. Evidence surrounding the function(s) of polyphenol-rich foods in bone health is examined, along with more recent studies challenging the relevance of caffeine consumption to in vivo Ca balance. Plant foods rich in polyphenols such as tea, fruit and vegetables, as significant factors in a healthy diet and lifestyle, may have positive roles in bone health, and the negative role of caffeine may have been overestimated. The present review covers evidence of dietary mediation in positive and negative aspects of bone health, in particular the roles of tea, fruit and vegetables, and of caffeine, flavonoids and polyphenols as components of these foods. Since the deleterious effects of caffeine appear to have been overstated, especially in respect of the positive effects of flavonoids, it is concluded that a reassessment of the role of caffeinated beverages may be necessary.
Development of a novel bioassay for determining the available lysine contents of foods and feedstuffs
Authors: Rutherfurd Shane M. , Moughan Paul J.
Published: June 2007

Lysine is an important indispensable amino acid, and describing the lysine content of a food or feedstuff provides useful information about nutritional value. However, when a food or feedstuff is subjected to heating the lysine present can be altered to nutritionally unavailable derivatives. These derivatives can revert back to lysine during the acid hydrolysis step used in amino acid analysis causing an overestimate of the lysine content. There have been many chemical methods developed to determine the reactive (unmodified) lysine content of foods and feedstuffs, but these do not take into account the incomplete absorption of lysine from the small intestine. There are also a number of animal-based assays for determining available lysine (the lysine that can be absorbed in a form that can be used for protein synthesis). The true ileal amino acid digestibility assay is commonly used to determine amino acid availability and is accurate for application to unprocessed foods and feedstuffs but is not accurate for lysine and possibly other amino acids when applied to heat-processed foods or feedstuffs. For such protein sources, assays such as the slope-ratio assay, indicator amino acid oxidation assay and the BIOLYSINE™ assay (true ileal digestible reactive lysine assay) have been developed to determine available lysine. The present paper discusses the efficacy of the BIOLYSINE™ assay as well as other assays for determining available lysine in processed foods and feedstuffs.
Vitamin D3and the immune system: maintaining the balance in health and disease
Authors: Baeke Femke , Etten Evelyne Van , Overbergh Lut , Mathieu Chantal
Published: June 2007

1,25-Dihydroxyvitamin D3(1,25(OH)2D3), the active form of vitamin D3, is a central player in Ca and bone metabolism. More recently, important immunomodulatory effects have been attributed to this hormone. By binding to its receptor, the vitamin D receptor, 1,25(OH)2D3regulates the expression of various genes and consequently affects the behaviour of different cell types within the immune system. 1,25(OH)2D3can potently inhibit pathogenic T cells and gives rise to elevated numbers of regulatory T cells via the induction of tolerogenic dendritic cells. These immunomodulatory activities of 1,25(OH)2D3have also been proven usefulin vivo: administration of 1,25(OH)2D3in several animal models can prevent or cure different autoimmune diseases and graft rejection. To overcome the dose-limiting side effects of 1,25(OH)2D3on Ca and bone, less calcaemic structural analogues (alone or in combination with synergistically acting drugs or bone-resorption inhibitors) have been successfully used in animal models. Furthermore, as 1,25(OH)2D3also contributes to host defence against infectious agents by the induction of antimicrobial responses, this molecule might provide a new strategy to deal with drug-resistant infections. According to the pleiotropic effects of 1,25(OH)2D3in the immune system, increasing epidemiological data underline the importance of adequate vitamin D intakes in reducing the risk of several autoimmune diseases and infections such as tuberculosis.
The aetiology of childhood obesity: a review
Authors: Procter Kimberley L.
Published: June 2007

Whilst the prevention of childhood obesity is the only viable, enduring, cost-effective solution to the obesity epidemic, effective methods for it remain elusive. Furthermore, strategies to influence obesogenic environments remain relatively unexplored. In order to be able to develop powerful population-level interventions and public health policies to prevent childhood obesity, it is important to understand its aetiology and those environments that are most amenable to measurable change. First, the present paper considers why we should be concerned about obesity in children, from both the perspective of the increased health risk to the individual and the high economic cost of treatment of obesity and related diseases, highlighting why the prevention of childhood obesity is important. Next, the determinants of health behaviour and the obesogenic environment are explored, which helps us to understand why the aetiology is so complex and that potential causal factors should not be considered in isolation, as the interaction between these factors is also important. The paper then considers the multi-factorial aetiology of childhood obesity and the rationale for the increasing trends in obesity that are evident, in order to understand what is changing in society and our children's behaviour that is triggering the positive energy balance leading to obesity. The review emphasises the need for multi-level approaches if we truly want to prevent childhood obesity. It also serves to highlight that there is a need to extend the current research base in order to build a well-founded framework to form the basis of a strategy for the prevention of childhood obesity.
Severely obstructed totally anomalous pulmonary venous return with residual connection to the left atrium
Authors: Eng Loh Lik , Brown Katherine , Marek Jan
Published: June 2007

Totally anomalous pulmonary venous return may present diagnostic difficulty to clinicians, as it often appears similar to severe neonatal pulmonary disease. We describe a neonate who presented with severely obstructed pulmonary venous return, but with a residual venous connection to the left atrium. The unusual anatomy confounded the diagnosis. To our knowledge, this particular permutation has not previously been described. Our experience indicates that echocardiographic interrogation should be repeated in cases where there is no response to conventional therapy, and all individual pulmonary veins should be observed carefully.
A prospective, randomized, double-blind, placebo controlled trial of beta-blockade in patients who have undergone surgical correction of tetralogy of Fallot
Authors: Norozi Kambiz , Bahlmann Jens , Raab Björn , Alpers Valentin , Arnhold Jan O. , Kuehne Titus , Klimes Katrin , Zoege Monika , Geyer Siegfried , Wessel Armin , Buchhorn Reiner
Published: June 2007

Aims

Our purpose was to evaluate the effect of a treatment over six months with bisoprolol on the surrogate parameters of N-Terminal-pro brain natriuretic peptide, subsequently to be described as brain natriuretic peptide, peak uptake of oxygen, and ventricular function assessed by magnetic resonance imaging in grown ups and adults who had undergone surgical correction of tetralogy of Fallot.

Methods and results

We designed a prospective, randomized, double-blind, placebo controlled trial. We enrolled 33 patients, aged 30.9 plus or minus 9.5 years in either class 1 or 2 of the grading of the New York Heart Association class with both levels of brain natriuretic peptide greater than 100 pg/ml and a reduced peak uptake of oxygen less than 25 ml/kg/min. During treatment with Bisoprolol, the levels of brain natriuretic peptide increased significantly from 206 plus or minus 95 to 341 plus or minus 250 pg/ml (p< 0.05), and those of atrial natriuretic peptide from 4117 plus or minus 1837 to 5340 plus or minus 2102 fmol/ml (p = 0.0005). These measures remained unchanged in the group of patients receiving the placebo. Peak uptake of oxygen did not differ significantly in either group, nor did treatment have any significant effect on right and left ventricular volumes and ejection fractions as determined by magnetic resonance imaging. The clinical state as judged within the grading system of the New York Heart Association was also unchanged by beta-blockade.

Conclusion

Beta blockade with Bisoprolol seems to have no beneficial effect on asymptomatic or mildly symptomatic patients with right ventricular dysfunction secondary to repaired tetralogy of Fallot with residual pulmonary regurgitation and/or stenosis.
Progressive fetal atrioventricular block in heterotaxy syndrome
Authors: Swaminathan Sethuraman , Parthiban Anitha
Published: June 2007

We report a fetus with left isomerism, in whom the atrioventricular block progressed from low grade second degree to complete block and fetal hydrops. While it is known that there is a high incidence of heart block in the fetus with left isomerism, as far as we are aware, ours is the first report of Wenckebach type block documented in the fetus by Doppler echocardiography, and demonstration of the progression of heart block during fetus life in the setting of left isomerism.
A novel percutaneously adjustable device for ligature of the vertical vein in the setting of obstructive totally anomalous pulmonary venous connection
Authors: Chowdhury Ujjwal K. , Mishra Anand , Saxena Anita , Kothari Shyam S. , Malhotra Amber , Mahajan Rajiv , Honnakere Jayanth H.V. , Venugopal Panangipalli
Published: June 2007

Background

A patent vertical vein might be desirable in patients with obstructive totally anomalous pulmonary venous connection with pulmonary hypertension, in order to decrease perioperative pulmonary arterial pressure and avoid pulmonary hypertensive crises. A subset of patients with an unligated vertical vein requires interruption of the vein due to the development of significant left-to-right shunt and right heart failure. We describe here a new device, permitting adjustable ligation of the vertical vein, which permits us to avoid multiple reoperations.

Patients and methods

In five patients, aged 2, 4, 3, 4, and 3 months respectively, and undergoing rechannelling of totally anomalous pulmonary venous connection with an unligated vertical vein, were treated with a device permitting adjusted ligation of the vertical vein over the course of postoperative congestive cardiac failure.

Results

There was no early or late death. Postoperatively, all ligatures were tightened gradually over a period of 24 to 96 hours, maintaining stable haemodynamics. At a mean follow-up of 55.40 months, there was no evidence of congestive heart failure in any patient, the clinical risk score varying from zero to 2, and no requirement of anti-failure medications. Computed tomographic angiograms during follow-up revealed absence of flow through the vertical vein, and ruled out distortion of the left upper pulmonary and left brachiocephalic veins.

Conclusion

Use of a percutaneously adjustable device to ligate the vertical vein allows gradual tightening or loosening of the ligature under optimal physiologic conditions, without re-opening the sternum, or having to resort to another thoracotomy once the reactive components of pulmonary hypertension disappear.
Dynamic household models of forest clearing under distinct land and labor market institutions: can agricultural policies reduce tropical deforestation?
Authors: TAKASAKI YOSHITO
Published: June 2007

This paper develops four agricultural household models of forest clearing – as both an input for current production and an investment in future production – over two periods under distinct land and labor market institutions. Five different effects of policies on farmers' forest clearing decisions are identified. Careful comparison of their relative magnitudes reveals (potential) pro-forest policies under distinct market conditions. In Latin American countries, poor early settlers are often bid off their cleared land after or without cultivation by wealthy large holders. With this ‘sell-out effect,’ price transfer and technological transfer for soil management targeting poor colonists and policy reforms eliminating land price distortions are recommended to arrest deforestation. On the other hand, especially in places where land transaction opportunities are nil like Sub-Saharan African countries, policies promoting non-agricultural activities among poor farmers are needed.
Economic integration, environmental harmonization and firm relocation
Authors: BARBIER EDWARD B. , HULTBERG PATRIK T.
Published: June 2007

As different regions of the world integrate, many questions arise regarding the effect on the location of firms. A firm's decision to relocate operations when its home country integrates with another region is in general influenced by the relative marginal cost of production between the regions, the cost of relocation, the cost of exporting its good across borders, as well as the relative size of the two regions. Except for market size, these variables crucially depend upon the degree of economic integration, ranging from simple bilateral trade agreements, to agreements that make foreign direct investment easier and cheaper, to full economic integration that harmonizes policies across the regions. We develop a model in which we explore the possible forms of integration in the context of two illustrative applications: US–Mexico under NAFTA and Central and Eastern European countries and the European Union.
Energy system change and external effects in climate change mitigation
Authors: ANDERSON DENNIS , WINNE SARAH
Published: June 2007

Through a dynamic model of energy system change the paper examines the role of innovation in bringing about a low carbon energy system. The processes of innovation and technological substitution are cumulative, dynamic, and highly non-linear processes such that how the energy system evolves in the long term is extraordinarily sensitive to the strength and duration of the initial policies. It is possible, under some policy assumptions, that energy systems would continue to depend on fossil fuels for so long as fossil fuels remain abundant and the least cost resource; and under other assumptions, after allowing for the unavoidable lags associated with investment and the building up of a new capital stock, that fossil fuels would become almost wholly displaced by the non-carbon alternatives. The implication is that the external benefits of innovation, which include the creation of options and the reduction of costs arising directly from innovation itself, and the reduction of environmental damage, are far greater, perhaps by orders of magnitude, than the traditional cost–benefit models used for the analysis of climate change mitigation. The analysis suggests why a focus on discovery and innovation offers a promising way forward for national and international policies on climate change.
Beyond the Environmental Kuznets Curve: a comparative study of SO2 and CO2 emissions between Japan and China
Authors: YAGUCHI YUE , SONOBE TETSUSHI , OTSUKA KEIJIRO
Published: June 2007

This study is the first systematic attempt to test statistically the contrasting hypotheses on the emission of SO2 and CO2, and energy consumption in Japan and China for the last few decades. We postulate the hypotheses that local governments have incentives to internalize the local external diseconomies caused by SO2 emissions, but not the global external diseconomies caused by CO2 emissions. To substantiate our hypotheses, we decompose emissions of SO2 and CO2 into two factors: the emission factor (i.e. emission per energy use) and energy consumption. The results show that the prefectures where past energy consumption was high tend to reduce the emission factor of SO2 significantly in Japan, while we do not find such a tendency in China. There is also evidence that neither per capita income nor past energy consumption affects the CO2 emission factor and energy consumption significantly in both Japan and China, implying that an individual country has few incentives to reduce CO2 emissions.
Climate variability and flexibility in resource access: the case of pastoral mobility in Northern Kenya
Authors: MCCARTHY NANCY , DI GREGORIO MONICA
Published: June 2007

In many regions of the world, property rights to natural resources are held under various forms of communal ownership, which often exhibit flexibility for users to access different resources depending on relative need. This paper explores the links between climate variability, transactions costs associated with resource access, and patterns of herd mobility in northern Kenya. Results indicate that greater spatial variability of vegetation leads to greater herd mobility, and that higher transaction costs reduce mobility for herds engaged in long-distance movements. Moreover, long-distance mobility is higher in drought years only in those communities with greater spatial and seasonal variability of vegetation.
Benefits and costs to China of a climate policy
Authors: AUNAN KRISTIN , BERNTSEN TERJE , O'CONNOR DAVID , PERSSON THERESE HINDMAN , VENNEMO HAAKON , ZHAI FAN
Published: June 2007

In future agreements to cut greenhouse gases, a Chinese commitment will probably be essential. Committing for China is easier if the cost is low and the benefit to China is high. Using a new CGE-model of the Chinese economy we discuss the cost and benefit to China of taking on a climate commitment. We argue that a climate commitment gives significant ancillary benefits to China since associated particle and NOx-reductions improve public health and increase agricultural yields. The model of impact on agricultural yields is a novel feature of CGE-models. Comparing benefits to economic costs produces striking results. We find that China may reduce its CO2-emissions by 17.5 per cent without suffering a welfare loss. Half of the benefit originates in the novel agricultural model. We also discuss the distributional impact of a climate commitment. In general the distributional impact is not averse.