bluuebunny/crossref_metadata_2025 huggingface dataset:
High performance transmissive color filter with hybrid Tamm plasmon-cavity modes
Authors: Chen Haohan , Zheng GG
Published: April 2022

A dual distributed Bragg reflector (DBR)-based structure embedded with silver (Ag) layer is proposed to demonstrate a transmissive color filter induced by the optical Tamm states (OTSs). The hybrid formation ensures optical Tamm resonance can be excited and the energy is concentrated at the DBR/Ag interface, resulting in a sharp transmittance feature with a narrow bandwidth. To optimize the device performance with desired red-green-blue (RGB) additive colors, transfer matrix method is carried out for simulations. The resonances and corresponding color appearance can be tailored dynamically through the manipulation of the Bragg wavelength and the angle of incident light. Through adjusting the structural parameters, the wavelength of transmission peak could be fixed at 455 nm, 550 nm and 620 nm, respectively. Thus, chromaticity points with a large color gamut space in the CIE coordinate can be constructed. The structure is totally planar and the fabrication process is lithography-free, which may find great potential in the application of optical thin films.
Breather and its interaction with rogue wave of the coupled modified nonlinear Schrödinger equation
Authors: Wang Ming , Xu Tao , He Guoliang , Tian Yu
Published: April 2022

In this paper, we investigate the coupled modified nonlinear Schödinger equation. Through the traditional Darboux transformation, we construct the first-order breather solution which can exhibit Akhmediev breather and general breather. To obtain the higher-order localized wave solution, N-fold generalized Darboux transformation is given. Under the condition that the characteristic equation admits a double-root, we present the expression of first-order interactional solution. Then we graphically analyze the dynamics of breather and rogue wave. Due to the simultaneous existence of nonlinear and derivative terms in the equation, there presents different profile in two components for the breathers.
Prognostic and clinicopathologic significance of lncRNA SNHG17 in multiple human cancers: a meta and bioinformatic analysis
Authors: Sun Ningxin , Song Yanmei , Li Danyang , Jia Weihui , Yang Ke , Wang Jiemin , Li Hongli , Yin Chonggao
Published: April 2022

Background:In recent years, some studies have found that long non-coding RNA Small nucleolar RNA host gene 17 (lncRNA SNHG17) is abnormally expressed in a variety of cancers. However, the prognostic and clinical value of lncRNA SNHG17 expression in cancer is still unclear. This meta-analysis aims to comprehensively elaborate the prognostic value of SNHG17 in cancer.Methods:PubMed, Web of Science, Embase and Cochrane Library were absolutely searched. Hazards ratios (HRs) or odd ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic value of SNHG17 in cancers, including overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), recurrence-free survival (RFS), age, gender, tumor size, differentiation, metastasis, clinical stage, and lymph node metastasis (LNM). In addition, we further searched for the expression and prognosis of SNHG17 in various cancer through TCGA dataset.Results:13 studies containing 1492 cancer patients was finally Selected into this study. The results showed that patients with high SNHG17 expression tended to have shorter OS (HR = 1.78, 95%CI = 1.50-2.10, P < 0.01), DFS (HR = 1.36, 95%CI = 1.06-1.74, P < 0.05), RFS (R = 2.49,95%CI = 1.13-5.49, P < 0.01), and PFS (R = 2.02, 95%CI = 1.24–3.28, P < 0.05). Additionally, increased lncRNA SNHG17 expression was significantly related to worse differentiation (HR = 1.41, 95%CI = 0.82-2.45, P < 0.01), advanced clinical stage (HR = 3.25, 95%CI = 1.77-5.97, P < 0.01), earlier metastasis (HR = 2.33, 95%CI = 1.30-4.19, P < 0.01) and earlier lymph node metastasis (HR = 2.94, 95%CI = 2.15-4.02, P < 0.01). No publication bias was found in all studies and the results were robust. The TCGA dataset further validated that SNHG17 is highly expressed in a variety of cancers and is strongly correlated with OS and DFS.Conclusion:The high expression of lncRNA SNHG17 may predict poor prognosis and advanced clinical stage, which means that SNHG17 may be a possible prognostic biomarker of cancer.
An Analytical Formulation to Extract the Capacity Curve of Steel Structures
Authors: Shamivand Abbas , Akbari Jalal , Allahyari Parastoo
Published: April 2022

Among the methods for evaluating the nonlinear performance of structures, pushover analysis is an appropriate alternative instead of direct time history analysis. To accurately extract the capacity curve of a structure, according to the loading regulations/protocols such as FEMA-356 and ATC-40, lateral loads are incrementally applied to the structure in laboratory tests until the structural's failure occurs. Because of the cost and time-consuming nature of experimental tests, proposing mathematical/analytical methods could be the appropriate tools to predict the capacity curves of structures. The present study proposes a new method to find the capacity curves of cantilever steel beams based on mathematical formulations, structural analysis, and material properties. The reason to select a simple beam for this study is to discover all aspects of the system's nonlinear behavior. The strains, stresses, and other responses corresponding to large geometrical deformations have been extracted in two cases with and without strain hardening by considering changes in the behavior of materials. The proposed method has been verified using the finite element method with Abaqus software. The results indicate that the proposed model has acceptable accuracy and could be applied in the pushover analysis of steel structures.
Evaluating the Nexus Between Crude Oil Price, Natural Gas Price and Electricity Tariff: Evidence From Nigeria
Authors: OJO Ademola , Amassoma Ditimi , Adelakun Johnson
Published: April 2022

Background
The responsibility for transformation of Nigeria’s socioeconomic milieus is on the heels of required performance of her energy resources particularly the trio of crude oil, natural gas and electricity. However, the question is whether there is relationship between the market prices of these energy resources and whether the energy resources prices could have significant negative and or positive effects on each other thereby stimulating a new possible equilibrium.
Methods
It is therefore set out to achieve this objectives by adopting time series data of the trio resources between 1980 and 2021, analyzed using Bound test approach of Autoregressive Distributed Lag (ARDL), Vector Autoregressive (VAR) model and pairwise causality test to determine the variables’ cointegration, relationship and causal effects.
Results
The study found that the trio of crude oil price, natural gas price and electricity tariff as energy resources are cointegrated with long run relationship but with no significant causal effect amongst them.
Conclusion
The study concluded there is existence of relationship but disproportional effects between the trio of Natural Gas Price (NGP), Electricity Tariff (EET) and Crude oil Price (COBP) in Nigeria’s energy market. The study advocates government intervention in the energy market to reduce associated factors that attracts impact of increase energy resources prices on the citizens’ welfare outcomes.
Omics approach to reveal the effects of obesity on the protein profiles of the exosomes derived from different adipose depots
Authors: Chen Minting , Zhang Fan , Chen Baisen , Lau Condon , Huo Chuying , Han Quanbin , Su Tao , Kwan Hiu Yee
Published: April 2022

Background: Obesity affects the cargo packaging of the adipocyte-derived exosomes. Furthermore, adipocytes in different adipose tissues have different genetic makeup, the cargo contents of the exosomes derived from different adipose tissues under obesity should be different, and hence their impacts on the pathophysiological conditions. Methods and Results: iTRAQ-based quantitative proteomics show that obesity has more prominent effects on the protein profiles of the exosomes derived from subcutaneous adipose tissue (SAT-Exos) in the diet-induced obesity (DIO) mice than those derived from epididymal adipose tissue (EAT-Exos) and visceral adipose tissue (VAT-Exos). The differential expressed proteins (DEPs) in SAT-Exos and VAT-Exos are mainly involved in metabolism. Subsequent untargeted metabolomic and lipidomics analysis reveal that injection of these SAT-Exos into the B6/J-Rab27a-Cas9-KO mice significantly affects the mouse metabolism such as fatty acid metabolism. Some of the DEPs in SAT-Exos are correlated with fatty acid metabolism including ADP-ribosylation factor and mitogen-activated protein kinase kinase kinase-3. Pathway analysis also shows that SAT-Exos affect adipocyte lipolysis and glycerophospholipid metabolism, which is in parallel with the enhanced plasma levels of fatty acids, diglycerides, monoglycerides and the changes in glycerophospholipid levels in DIO mice. Conclusion: Our data provide evidence to suggest SAT-Exos contribute to the changes in plasma lipid profiles under obesity conditions.
The impact of COVID-19 pandemic-related quarantine on female sexual behavior：A cross-sectional study in Chinese
Authors: Li Guangyong , Yu Puguang , Zhang Fen , Xu Yanlong , Zhou Gaiyan , Zhan Xuekang , Gao Yu , Liu Hetao , Du Xaoli , He Rui
Published: April 2022

Aim: To investigate the impact and factors of home quarantine life on women's sexual life and behavior in different areas of China, and analyze the prevalence of female sexual dysfunction (FSD) during the COVID-19 epidemic.
Methods: We selected adult women (over 18 years old) who have regular sexual life (including regular masturbation) and had been isolated at home for at least one month during the COVID-19 outbreak. We use online questionnaires to survey respondents, the content of this questionnaire includes three parts: general demographic information, the impact of the epidemic on sexual life, and the Female Sexual Dysfunction Scale.
Results: After screening, a total of 678 complete questionnaires were recovered in this study. The results showed that during the epidemic, the overall score of female sexual dysfunction (FSFI) was 21.98±6.38, the incidence of FSD was 61.9%, the incidence of FSD in Shanghai, Nanjing, and Ningxia were 60.6%, 75.2%, and 52.2%, respectively. The differences in the incidence of FSFI score and other specific items (Desire, Arousal, Lubrication, Orgasm, Satisfaction, and Pain) are in the three regions were statistically significant (P<0.05). In a separate analysis of women who used masturbation for sex, we found that the incidence of FSD was 34.4%, which was lower than paired sexual intercourse 60.1%.(p<0.05). Further analysis we found that the occurrence of FSD during the epidemic was related to different age stages, menopause, mode of delivery, degree of anxiety and depression, and different sexual lifestyles.
Conclusion: The COVID-19 epidemic has had a great impact on people's spiritual life and sexual life. This impact has a negative impact on mental health, but for sex life it has both negative and positive effects, which is mainly caused by it is determined by the characteristics of this life mode of home isolation. In addition, we comparatively analyzed the sexual health status and influencing factors of sexual intercourse and masturbation groups during the epidemic, which helps us to care about the sexual health of masturbation population. Finally, we also found that sex knowledge and education are lacking in many women, which may be the root cause of sex unhealthy. And we should pay attention to the importance of sexual health in epidemic, and having a harmonious and stable sex life will help us get through the boring life of isolation.
Revealing Urban Activity Patterns Around Metro Stations through Social Media Network Data
Authors: Mohammadbagherzadeh Sanaz , Terzi Fatih
Published: April 2022

Stations on the metro system are important transportation hubs that handle a large number of the daily trip. Through the metro stations that facilitate pedestrian mobility and serve as a magnet for businesses, public transportation systems have the potential to alter the character of a community depending on the circumstances. Using location-based social network (LBSN) data, this study aims to quantify the area surrounding metro stations and metro lines, as well as to conduct a cluster analysis of Istanbul metro stations based on the pattern of LBSN data to gain insights into the characteristics of each station's surrounding area. To this end, the Foursquare venue data were gathered using the Foursquare API database. Then the data was cleaned and categorized based on the main activity and mapped in ArcGIS pro. K means cluster analysis was performed based on different venue activities around each station. Based on various venue activities, 77 Metro stations are classified into three types, namely undeveloped stations, developed stations, and touristic stations. The majority of stations were placed in undeveloped groups with a low activity level. The developed stations are mainly located in the commercial and touristic areas.
The use of Uio-66 Metal-Organic Frameworks as a high-performance catalyst for the isomerization process of endo- to exo-dicyclopentadiene in a solvent-free condition
Authors: Maghsoodi Narjes Khaton , Keshavarz Mohammad Hossein
Published: April 2022

Exo-tetrahydrodicyclopentadiene (tricyclo[5.2.1.02,6]decane) or JP-10 is a synthetic jet fuel, which can be used as a high-density fuel in the air-breathing missile engineers and supersonic combustion ramjets. It can be produced from the fully saturated version of exo-dicyclopentadiene (exo-DCPD). This work introduces a new green method for isomerization of endo-dicyclopentadiene (endo-DCPD) to exo- form in the presence of Metal-Organic Frameworks (MOFs). The synthesized UiO-66 and UiO-66-vac as two suitable MOF catalysts are used for the isomerization process in a solvent-free condition. The design of the experiment is used to optimize reaction conditions including time, temperature and catalyst loading. High yield and excellent conversion of endo- to exo-DCPD are obtained by reacting with UiO-66-vac at lower levels of time and temperature. Solvent-free, environmentally friendly, simple reaction process, reusable catalyst, and availability of materials are advantages of this process.
Committee integration of optimized models for prediction of compressive strength of masonry structures
Authors: Gholami Mahsa , Gholami Amin
Published: April 2022

An accurate computation of the compressive strength of masonry structures (CSMS) is an overarching factor in design and construction of masonry structures (MS). This considerable significance compels researchers to propose an appropriate, reliable and, more generalized method whereby the precise value of CSMS is calculated. In the current study, a committee machine (CM) with optimized elements is constructed, thereby extracting a non-linear relationship between CSMS with compressive strength (CS) of mortar and brick. In order to accomplish this objective, three intelligent models viz. neural network (NN), fuzzy inference system (FIS), and support vector regression (SVR) are firstly optimized with bat-inspired algorithm (BA), and these improved models are subsequently applied for estimation of CSMS. BA is hybridized with intelligent models for extracting the best values of weights and biases of NN, membership’s functions of FIS, and user-defined parameters of SVR. Then, CM is utilized for amalgamating the outputs of three optimized models (OMs) incl. optimized neural network (ONN), optimized fuzzy inference system (OFIS), and optimized support vector regression (OSVR). BA is also embedded in the structure of CM, thereby determining the optimal contribution of each optimized model in the final prediction. Data sets including 96 records accessible in the literature are used to learn and evaluate the constructed models. Appraisal of the accuracy based on statistical parameters verified that the CM could effectively improve the prediction accuracy of the OMs and also has a better performance compared to commonly well-known predictive correlations. This study also proved that CM with optimized elements is a very convenient approach for mapping nonlinear functions between CSMS and CS of brick and mortar.
Nervous System Involvement in Patients Hospitalized at the COVID-19 Isolation Hospital in Alexandria University, Egypt: Clinical Findings
Authors: Abdelaziz Osama S. , Waffa Zuraiha , Abdelsalam Wael N. , Helmy Tamer A. , Nosseir Ayman A.
Published: April 2022

Background
Global studies have exemplified that COVID-19 has neurological manifestations. This study gives an insight to the impact of COVID-19 on the nervous system in Alexandria, Egypt and identifies predictors of severity and mortality.
Methods
This single centre, retrospective, observational study was conducted from August 1st, 2020 to January 31st, 2021, on patients admitted at the COVID-19 Isolation Hospital in Alexandria University, Egypt. A Neuro-COVID patient was defined as confirmed COVID-19 case presenting with one or more new onset nervous system finding.
Results
Out of 1073 in-patients, 352 were Neuro-COVID patients (183 [52%] females and 169 [48%] males). The mean age was 36.64 ± 18.97 years and 161 (45.7%) had comorbidities. Most common involvement was neuromusculoskeletal system (240 [68.2%]), followed by central nervous system (164 [46.6%]) and peripheral nervous system (125 [35.5%]), whereas, psychiatric disorders (4 [1.1%]) were the least common. Myalgia (215 [61.1%]); anosmia (118 [33.5%]); headache (100 [28.4%]); ageusia (80 [22.7%]); altered level of consciousness (56 [15.9%]); arthralgia (43 [12.2%]) and dizziness (12 [3.4%]) were predominant presentations. Female Neuro-COVID patients were twice as more likely to be critical than moderate (P =0.030). Critical cases with nervous system presentations manifested 12 times higher risk of death when compared to severe cases (P <0.001).
Conclusions
Nervous system involvement was predominant and clinically significant in COVID-19. Disease severity was identified as an independent predictor of mortality in Neuro-COVID patients.
Phosphatidylcholines (PCs) serve as biomarkers for prognosis of esophageal squamous cell carcinoma (ESCC) and compromise antitumor efficacy of focal adhesion kinase (FAK) inhibitor
Authors: Zhan Qimin , Chen Jie , Zhang Lingyuan , Zhao Di , Zhang Jing , Xiao Yuanfan , Wu Qingnan , Wang Yan
Published: April 2022

Abnormal metabolism is recognized as an oncogenic hallmark that is correlated with tumor progression and therapeutic resistance. Here, we used multi-omics, including phosphoproteomics, untargeted metabolomics and lipidomics to demonstrate that the cancer-associated fibroblasts (CAFs)-derived AKT2/choline-phosphate cytidylytransferase α (CCTα)/phosphatidylcholines (PCs) axis mediated the resistance of focal adhesion kinase (FAK) inhibitor-defactinib in esophageal squamous cell carcinoma (ESCC) treatment. We first identified extremely low levels of FAK Tyr397 expression in CAFs, which might possibly provide no available target for defactinib exerting its anti-growth effect in CAFs. Consequently, defactinib upregulated the intracellular concentration of Ca2+ in CAFs, and facilitated the formation of AKT2/CCTα protein complex to phosphorylate CCTα Ser315/319/323 sites, and finally enhanced the production of stromal PCs, which activated intratumoral Janus kinase 2 (JAK2)/Signal transducer and activator of transcription 3 (STAT3) pathway to induce resistance of FAK inhibition. Analysis of clinical samples showed that stromal pAKT2 Ser128 and pCCTα Ser315/319/323 were associated with the tumor malignancy and reduced patient survival. Pseuo-targeted lipidomics and further validation cohort quantitatively demonstrated that plasma PCs allow to distinguish the malignant extent of ESCC patients. Overall, inhibition of stroma-derived PCs and related pathway might be used as potential therapeutic strategies for tumor treatment.
A Proposed Model for Card Fraud Detection Based on CatBoost and Deep Neural Network
Authors: Nguyen Nghia , Duong Truc , Chau Tram , Nguyen Van-Ho , Trinh Trang , Tran Duy , Ho Thanh
Published: April 2022

Rapid development of technology has digitized customers' payment behavior towards a cashless society. To some extent, this has created a feast for miscreants committing fraud. According to Nilson’s Report (2020), the global fraud loss is projected to reach over $35 billion in 2025. Thus, the need for a novel method to prevent this menace is undisputed. Studies in fraud detection in cards abound with various machine learning-based techniques. However, many of them were conducted on modest-sized sample with a few familiar features and mainly focused on transaction-based approach to detect fraud. These models fail to satisfy low false alarm rates when being fed with large-scale data streams. In this paper, an innovative model was proposed to improve classification accuracy based on the idea of user separation, in which we divided users into old and new people before applying CatBoost and Deep Neural Network on each category, respectively. The experimental result shows that our model achieved better as we obtained AUC score of 0.97 (CatBoost) and 0.84 (Deep Neural Network).
Effects of omalizumab treatment on gut microbiome in adolescent patients with chronic spontaneous urticaria
Authors: Wang Mei , Zhao Leran , Zeng Sanwu , Qin Yongzhang , Wang Jiangyi , Jin Jingji , Weng Lishou , Wang Dong , You Cong
Published: April 2022

Background: Omalizumab is a humanized anti-immunoglobulin (Ig)E monoclonal antibody that is effective for some patients with chronic spontaneous urticaria (CSU) who do not respond to antihistamines. However, the mechanism by which omalizumab improves urticaria remains obscure. Gut microbiome plays a role in the pathogenesis of allergies. Here, we aimed to investigate differences in gut microbiome of adolescent CSU patients before and after omalizumab treatment, which has not been reported until date. Methods: Ten adolescent patients with CSU were given 300 mg omalizumab subcutaneously in three treatment sessions at 4-week intervals. The personal and clinical factors of patients before and after treatment were collected. Urticaria Activity Score (UAS7) was applied to evaluate the efficacy of omalizumab treatment every 4 weeks during the follow-up period. Fecal samples were collected before treatment and at 12 weeks after the first treatment. Total DNA of the gut microbiota in all fecal samples were extracted. The 16S rRNA gene-targeted sequencing technology was used for the analysis of the diversity and distribution of gut microbiome, followed by bioinformatics analysis. Results: UAS7 scores decreased significantly after each omalizumab treatment sessions compared with the baseline (all P < 0.0001). The dominant bacteria in fecal samples before and after treatment were Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria at the phylum level. Alpha diversity analysis showed no significant difference before and after omalizumab treatment (P > 0.05) whereas beta diversity analysis revealed significant difference in the bacterial abundance before and after omalizumab treatment (P < 0.01) in adolescent patients with CSU. The relative abundance of Alphaproteobacteria and Betaproteobacteria at the class level and Burkholderia, Rhodococcus, and Sphingomonas at the genus level decreased significantly after omalizumab treatment (linear discriminant analysis > 4, P < 0.05). The functional prediction results showed that the differences noted before and after treatment were mainly in the dioxin and xylene degradation pathways, which were more abundant in adolescent patients with CSU before omalizumab treatment.Conclusions: Omalizumab is effective in treating CSU and can reduce the abundance of Alphaproteobacteria and Betaproteobacteria, which may help improve the treatment outcomes of CSU in adolescent patients.
Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation
Authors: Mishra Gyan Prakash , Jha Atimukta , Ahad Abdul , Sen Kaushik , Sen Aishwarya , Podder Sreeparna , Prusty Subhasish , Biswas Viplov K , Gupta Bhawna , Raghav Sunil Kumar
Published: April 2022

Tight control of gene regulation in dendritic cells (DCs) is important to mount pathogen specific immune responses. Apart from transcription factor binding, dynamic regulation of enhancer activity through global transcriptional repressors like Nuclear Receptor Co-repressor 1 (NCoR1) plays a major role in fine-tuning of DC responses. However, how NCoR1 regulates enhancer activity and gene expression in individual or multiple Toll-like receptor (TLR) activation in DCs is largely unknown. In this study, we did a comprehensive epigenomic analysis of murine conventional type-I DCs (cDC1) across different TLR ligation conditions. We profiled gene expression changes along with H3K27ac active enhancers and NCoR1 binding in the TLR9, TLR3 and combined TLR9 + TLR3 activated cDC1. We observed spatio-temporal activity of TLR9 and TLR3 specific enhancers regulating signal specific target genes. Interestingly, we found that NCoR1 differentially controls the TLR9 and TLR3 specific responses. NCoR1 depletion specifically enhanced TLR9 responses as evident from increased enhancer activity as well as TLR9 specific gene expression, whereas TLR3 mediated antiviral response genes were negatively regulated. We validated that NCoR1 KD cDC1 showed significantly decreased TLR3 specific antiviral responses through decreased IRF3 activation. In addition, decreased IRF3 binding was observed at selected ISGs leading to their decreased expression upon NCoR1 depletion. Consequently, the NCoR1 depleted cDC1 showed reduced Sendai virus (SeV) clearance upon TLR3 activation. NCoR1 directly controls the majority of these TLR specific enhancer activity and the gene expression. Overall, for the first time we revealed NCoR1 mediates preferential transcriptional control towards TLR9 as compared to TLR3 in cDC1.
Analysis of the risk of suicide and accidental death in patients with pancreatic cancer in the past 40 years
Authors: Tian Ye , Hou Jingwen , Wang Zonghui , Zheng Rui , Li Ruojin , Liu Yan , Wang Fan
Published: April 2022

Purpose: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18-registry Custom database (1975-2016) to determine the latest risk and risk factors of suicide/accidental death in pancreatic cancer patients. Methods: SEER*Stat was used to get the Standardized Mortality Ratio (SMR) for suicide/accidental death in pancreatic cancer patients. The Adjusted Risk Ratio (ARR) and risk factors for suicide/accidental death in pancreatic cancer patients were achieved by the multivariate Poisson regression model and multivariate Cox regression model.Results: Pancreatic cancer patients diagnosed within three months have the highest SMR of suicide (8.52, 95% Confidence Interval [CI]: 5.71-12.24) and accidental death (2.75, 95% CI: 1.98-3.72); Among the pancreatic cancer patients hadn’t performed surgery, patients classified as ‘Recommended but not performed’ have a higher ARR of suicide(3.35, 95% CI: 2.22-4.87) and accidental death(2.12, 95% CI: 1.53-2.87) than patients classified as ‘Not recommended’, the same trend also showed in the multivariate Cox regression model: The Hazard Ratio (HR) of ‘Recommended but not performed’ patients for suicide(Vs ‘Performed’, 2.68, 95% CI: 1.36-5.30) and accidental death(Vs ‘Performed’, 2.68, 95% CI: 1.36-5.30) higher than ‘Not recommended’ patients.Conclusion: Pancreatic cancer patients have a significantly higher risk of suicide and accidental death than the general population and other cancer patients, especially within three months of diagnosis. In addition, we found in the pancreatic cancer patients who hadn’t performed surgery, those ‘Recommended but not performed’ have a higher risk of suicide and accidental death than those ‘Not recommended’. Therefore, we suggest Department doctors collaborate with oncology psychologists and maintain regular touch with patients who are ‘Recommended but not performed’ and diagnosed within three months.
Fibroblasts And Mouse's Breast Cancer Cells Can Form Cellular Aggregates in Improved Soft Agar Culture Medium
Authors: Zhang Xiangnan , Liang Shuo , Wang Enze , Tao Ning
Published: April 2022

Purpose
Cancer-associated fibroblasts (CAFs) promote cancer cell growth, invasion and migration. In this research, we aimed to build cellular aggregates of mouse’s breast cancer cells (TS/A) and normal fibroblasts (LX-2) or CAFs (ME-iLX-2) in soft agar culture medium, verifying this co-culture model’s value in screening of anticancer drugs and preliminarily demonstrating the effect of CD44 in aggregates formation.
Methods
We improved soft agar culture medium to co-culture CAFs (NFs) and TS/A to build the cellular aggregates model, and compared the amount and area of different co-culture groups. To verify its value in screening of anticancer drugs, eugenol which has been demonstrated its anticancer effect was added into this model. The transcription of human CD44 was analyzed through Real-time quantitative PCR (RT-qPCR).
Result
TS/A-fibroblast cellular aggregates were formed in improved soft agar culture medium. What’s more, the amount and area of aggregates in TS/A-ME-iLX-2 co-culture group were significantly higher than in TS/A-LX-2 co-culture group. In co-culture group with eugenol, the amount and area of TS/A-ME-iLX-2 aggregates were lower than control group. The result of RT-qPCR showed that the transcription volume of human CD44 in TS/A-ME-iLX-2 aggregates was higher than in TS/A-LX-2 aggregates.
Conclusion
Co-culturing cellular aggregates of fibroblasts and TS/A was successfully formed in improved soft agar culture medium, and the amount and area of aggregates further confirmed CAFs’ promotion effect to cancer cells. Eugenol test showed its value in screening of anticancer drugs. RT-qPCR result demonstrated the important effect of CD44 in aggregates formation.
A Quality Assessment of Information Provided on Websites Selling Cannabis to Consumers in Canada
Authors: Ng Jeremy Y , Tahir Umair , Lum Nicholas
Published: April 2022

Background: Cannabis is used by millions of people for both medical and recreational purposes, and this use is even greater in jurisdictions where it is legalized, such as Canada. Online cannabis vendors have gained popularity for purchasing cannabis due to the easy access and convenience to consumers. The objective of this study was to evaluate the quality of health information provided by websites of cannabis vendors selling products to Canadian consumers, and to further identify trends in the information provided. Methods: Six different searches were conducted on Google.ca, and the first 40 webpages of each search were screened for eligibility. A total of 33 unique websites of cannabis vendors selling products to Canadian consumers were identified and included. The DISCERN instrument, which consists of 16 questions divided into three sections, was used to evaluate the quality of cannabis-related health information on these websites. Results: Across the 33 websites, the average of the summed DISCERN scores was 36.83 (SD = 9.73) out of 75, and the mean score for overall quality of the publication (DISCERN question 16) was 2.41 (SD=0.71) out of 5. Many of these websites failed to discuss uncertainties in research evidence on cannabis, the impact of cannabis use on quality of life, alternatives to cannabis use, risks associated with cannabis use, and lacked references to support claims on effects and benefits of use.Conclusion: Our findings indicate that the quality of cannabis-related health information provided by online vendors is poor. HCPs should be aware that patients may use these websites as primary sources of information, and appropriately caution patients while directing them to high-quality sources. Future research should serve to replicate this study in other jurisdictions and assess the accuracy of information provided by online cannabis vendors, as this was outside the scope of the DISCERN instrument.
Insolvency Resolution and Doing Business Reforms in BRICS Nations
Authors: Chawla Neelam , Kumar Basanta , Patel Gokulananda
Published: April 2022

This paper analyzes the factors responsible for the efficacy of resolving insolvency issues influencing the ease of doing business (EoDB) ranking in the BRICS (Brazil-Russia-India-China-South Africa) nations' context, with particular reference to India. Based on published data from the World Bank's EoDB reports, the paper analyzes the impact of EoDB parameters, particularly resolving insolvency issues, on its ranking. Besides, the study examines the legal framework of insolvency resolution that boosts stakeholders' confidence and improves the business environment. The research also investigates the legal framework of insolvency resolution vis-a-vis judicial pronouncement to understand government strategies, stakeholders' trust and the business environment aiding EoDB ranking. Descriptive statistics and analytical hierarchy process (AHP) were applied to analyze and interpret the findings and results. The key findings show that insolvency resolution has been one of the priorities of the governments in Brazil, Russia, and China almost during the last decade; India's importance came after the Insolvency and Bankruptcy Code (IBC), 2016 enactment. Resolving insolvency is the prime factor responsible for India's rank improvement, whereas it is not a priority for South Africa. The AHP in the Indian context proves that the government's importance to insolvency resolution moves in lockstep with expert opinions. The findings add value to the body of knowledge on insolvency resolution, contributing to the EoDB ranking vis-a-vis the business environment, and provide a broader implication for further research.
WITHDRAWN: Deep Learning Based CSI Feedback for Massive MIMO Aided IoT Networks with Edge Computing
Authors: Wu Di , Liu Zhusong , Sun Li , Li Chao , Zhou Wei , Li Yun , Wu Rui
Published: April 2022

Let us suppose we are given a complete, complete modulus H''. Recently, there has been much interest in the derivation of hulls. We show that Dⲉ,a is p-Russell and unique. Thus in this setting, the ability to compute fields is essential. It would be interesting to apply the techniques of [1] to embedded systems. It has long been known that ||ⲱ|| ≥ ℵ0 [1]. Moreover, is it possible to describe Einstein, globally linear, uncountable isometries? It has long been known that Ḡ is not greater than e'' [1]. On the other hand, the goal of the present paper is to construct co-compactly affine, finitely co-dependent subrings. In [1], the authors studied almost everywhere hyper-hyperbolic primes. Hence it is well known that there exists a linearly covariant functional. The groundbreaking work of J. Sato on Hermite random variables was a major advance.
Relativistic effect inside matter. Obtaining a relativistic dispersion formula.
Authors: Chernov Andrey
Published: April 2022

The main prerequisite for this study was the external similarity of such physical processes as the refraction of light in a transparent substance and the deflection of light by the gravitational field of massive cosmic bodies. Based on the external similarity, the author put forward a hypothesis about the internal similarity of these two physical processes. This made it possible to integrate Einstein's well-known relativistic formula into the process of light propagation in electron clouds (fields) of a transparent substance. As a result of the transformations carried out, a new physical dispersion formula with a wide spectrum of action was obtained from the Einstein formula. According to the new dispersion formula, 26 refractive indices of light were calculated in 5 transparent substances in 3 states of aggregation. Comparison of the obtained indicators with laboratory indicators showed the high accuracy of the new physical formula, which amounted to ±10 -7−10 -5 in the calculated sections of the wave ranges over 100 nm. The successful application of the relativistic formula to the process of light refraction in transparent substances indicates that relativistic effects are present at the atomic-molecular level.
Traffic models and traffic-jam transition in quantum (N+1)-level systems
Authors: NAVA ANDREA , Giuliano Domenico , Papa Alessandro , Rossi Marco
Published: April 2022

We propose a model to implement and simulate different traffic-flow conditions in terms of quantum graphs hosting an (N+1)-level
dot at each site, which allows us to keep track of the type and of the destination of each vehicle.
By implementing proper Lindbladian local dissipators, we derive the master equations
that describe the traffic flow in our system. To show the versatility and the reliability of our technique, we employ
it to model different types of traffic flow (the symmetric three-way roundabout and the three-road intersection). Eventually, we
successfully compare our predictions with results from classical models.
Addressing Wrongful Convictions or Miscarriages of Justice in the BRICS Nations
Authors: Mujuzi Jamil Ddamulira
Published: April 2022

For many decades, international human rights law has recognised the danger of wrongful convictions and miscarriages of justice. It is against this background that measures have been taken to prevent or combat wrongful convictions. Thus, Article14 of the International Covenant on Civil and Political Rights provides for the right to a fair trial as well as compensation in the case of amiscarriage of justice. The BRICS nations have implemented measures at the national level to prevent or combat wrongful convictions before and during trial as well as after conviction. These have included constitutional protection of the right to a fair trial, the establishment of a system to review convictions after the appeals process has been exhausted, should the offender exercise his or her right of appeal, and compensation for wrongful conviction in some countries. The purpose of this article is to highlight these measures and where needed, suggest ways in which these countries can learn from one another to prevent or minimise cases of wrongful convictions.
The Impact of Input and Output Prices on Indonesian Coffee Production and Trade Performance
Authors: Okim Fatkurrohim , Hanani Nuhfil , Syafrial Syafrial
Published: April 2022

Coffee is one of the most important agricultural plantation commodities in Indonesia, contributing 1.17 billion USD to the country's foreign exchange in 2017. Indonesia was also the world's fourth-largest coffee exporter from 2011 to 2017. However, the performance of coffee production and trade is very dynamic. In 2018, there was a significant drop in coffee exports by 40.23%, relegating Indonesia to sixth place even until 2020. Coffee production also fluctuates significantly, in contrast to the constantly rising coffee demand. This research aimed to figure out what factors influence Indonesian coffee production and trade performance. A simultaneous equation model using the 2SLS approach was employed as the methodology. The findings revealed that, in the production block, cocoa prices and interest rates had a significant influence ( 10%) on the coffee land areas. In contrast, domestic coffee prices, rainfall, and trends significantly impacted coffee productivity. Meanwhile, in the trade block, domestic coffee prices and non-tariff dummy barriers significantly influence Indonesia's total coffee exports. As a result, it can be deduced that changes in the input prices (substitution commodity prices, interest rates, rainfall, and trend) have a better impact on coffee production, while the output prices (domestic coffee prices) on the coffee trade performance.
La lucha contra la financiación del terrorismo y la criminalidad en Nigeria: opciones estratégicas
Authors: Falode Adewunmi J. , Chukwuemeka Nnamani E.
Published: April 2022

Este trabajo analiza los esfuerzos de Nigeria para contrarrestar la financiación del terrorismo y la criminalidad. Muestra que las organizaciones criminales y terroristas en el país costean sus operaciones a través de una infraestructura financiera ilegal incrustada en el sector financiero del país. Para contrarrestar y negar el acceso a estos actores no estatales malignos a fondos que podrían usarse para desestabilizar el estado y comprometer la integridad de las instituciones financieras, Nigeria ha implementado varias estrategias. Al utilizar una metodología de investigación cualitativa y un enfoque histórico, descriptivo y narrativo, se descubrió que Nigeria ha utilizado instituciones gubernamentales, como la Comisión de Delitos Económicos y Financieros (EFCC) y la Unidad de Inteligencia Financiera de Nigeria (NFIU), e instrumentos financiero-legales, como la Ley (de Prevención) (Enmienda) del Terrorismo (TPAA) y la Ley contra el Lavado de Dinero/Lucha contra el Financiamiento del Terrorismo (AML/CFT), para interrumpir el flujo de financiación al terrorismo y la criminalidad en el país. En su conclusión, el trabajo argumenta que Nigeria tendrá que ser estratégica en su respuesta si espera contrarrestar efectivamente la financiación del terrorismo y la criminalidad. Esta respuesta estratégica, según evidencia la investigación, implicará el uso extensivo de la experiencia técnica y financiera de organismos internacionales contra el lavado de dinero como el Grupo EGMONT y el Grupo de Acción Financiera Internacional (GAFI).
Paul Auster: Narrative and thought from a dual consciousness – The early fiction
Authors: Costa Jaime
Published: April 2022

Ever since the publication of his first novel in 1985, Paul Auster has come to be considered one of America’s most influential novelists. He has also, without doubt, gained both recognition and notoriety of a larger audience by his incursions into film and, sporadically, into theater. Interestingly enough, Paul Auster’s success was first more evident in Europe where he was and, perhaps, still is, considered the ‘most French’ of American writers. This vision does not correspond to reality; Auster belongs to the sturdy trunk of American storytelling based on the American Renaissance, the American Romantic literature of Nathaniel Hawthorne, Herman Melville and Edgar Allan Poe. Indeed, much of present day French high culture is indebted to American thought, arts and letters. Paul Auster has been remarkably well received in Europe which has always provided a receptive ground for American letters; let us remember that Edgar Allan Poe’s success and, eventual rescue from oblivion, was due to French symbolism; that Emerson both prefigured and influenced cardinal twentieth century philosophers Martin Heidegger and Jacques Derrida and that, in general, Walt Whitman greatly influenced twentieth century European literature from Modernism to Postmodernism. In Paul Auster, the American letters have an example of the‘strong poet:’ an ironist who approaches philosophy in the same way that Richard Rorty’s philosophy salutes literature. Auster’s books open their pages to a whole plethora of subjects that have as much to do with literature as with a large variety of concerns related to human existence and endeavors: history, linguistics, theology, and, above all, as we have just mentioned, philosophy. Accordingly, Auster’s works are part essay and part fiction. The works analyzed in this book represent an effort on the part of Paul Auster as novelist and literary author in dealing with the complexity of the nature of writing. All of his narratives have heroes who are writers or, in some way or another, approximate the ideal of a writer. In these books there is a concern for what should be the value of inward reality and, likewise, for the value to be attributed to the external realities. It is in the coalescence of these two realms that Auster’s works come to life. It is the self, that ultimate instance, which provides sense — order — to the reality of the various voices — stories — that constitute the reality of experience. Again, one reality always leads to the other and, in their turn, they once again lead to the generation of other stories in a process that parallels that of the continuous semiosis of language. These narratives, stories, address themselves to the ultimate goal of generating genuine thought in an independent way to the specific fields of metaphysics, philosophy or science.
Analysis of the concept of content marketing
Authors:   Faculty of Business, Kaunas University of Applied Sciences, Kaunas, Lithuania, et al. Dilys
Published: April 2022

This article discusses the concept of content marketing, and its objectives reveal the essence of content marketing and provide its structural model. The study presents the newest summarised results from the publications in the last decade. From this study, the authors concluded that content marketing should be understood as a type of marketing that includes sharing purposeful information in the digital space. Also, they concluded that content marketing happens through a mix of formation (e.g., aims, methods, tools of content marketing), interaction (e.g., co-sharing of formed content), and consequences (e.g., results like co-creation, other relationships), which affect formation and interaction. A structural model of content marketing is also provided. The authors reveal the uniqueness of content marketing based on the research and provide directions for further investigations.
The Korean 3T Practice: New Biosurveillance Model Utilizing New Information Technology and Digital Tools
Authors: Kim HyunJung
Published: April 2022

In South Korea, COVID-19 pandemic responses, namely the 3T (testing, tracing, and treating) strategy, emerged as a new biosurveillance regime actively using new information technology (IT) and digital tools. The foundation of the Korean 3T system is epidemiological investigation efforts and clinical practices exploiting the use of new digital and IT tools. Due to these unique features, the Korean 3T system can be referred to as a “contact-based biosurveillance system,” which is an advanced version of the traditional biosurveillance models (indicator-based or event-based models). This article illustrates how the contact-based biosurveillance system originated from the experience with the 2015 Middle East Respiratory Syndrome (MERS) outbreak. The post-MERS Korean biosurveillance regime actively adopted the utility of new digital and IT tools to strengthen not only the ex-ante epidemic intelligence capabilities (by traditional models) but also the ex-post response and recovery capabilities (digital contact tracing and digital health intervention). However, critics claim that the Korean 3T system may violate individuals’ privacy and human rights by addressing the fact that the Korean biosurveillance system would strengthen social surveillance and population control by the government as a “digital big brother” in the cyber age. Nevertheless, 3T biosurveillance promises a positive future direction for digital health practice in the current biosurveillance regimes.