bluuebunny/crossref_metadata_2025 huggingface dataset:
Shear Connectors Behavior Under Elevated Temperature: A review
Authors: K. Ali Ola , M. Ibrahim Amer , Hatif naji Abbas , A. Ali Ibrahim
Published: September 2024

A composite member is described as a structural steel shape that has been built up or rolled and filled with concrete, covered in reinforced concrete, or structurally attached to a slab of reinforced concrete. The shear connection between the steel beam and the concrete slab is the primary component of the composite beam. In risky situations, like building fires, the performance of a composite structures and steel structures are heavily dependent on the execution of connection. Numerous kinds of shear connectors exist and being utilized in the construction engineering rendering to their use. This paper reviews research conducted in the past years on the performance of shear connectors such as (ASTM A325 bolts, channel shear connector, T, T-mass and T-Proband shear connectors) exposed to raise heat degree. This research covers the experimental testing of push-out specimens, behavior of connectors in steel structures, various shapes of shear connectors under elevated temperatures, main failure modes, finite element modeling of shear connectors, design approaches offered by investigators, and various codes. Compared to the size of work available on shear connectors at room temperature, relatively slight research has been done on the conduct of shear connectors (studs) under high temperature. In addition, this report indicates several topics that need further investigations. Through this article, it was concluded that when temperatures raise, the strength of all shear connectors decreases proportionally regardless of its shape and type. A comparative study showed that the channel connectors are an economic and reliable option to standard shear connectors. Among the findings of some studies is that the effect of temperature on the shear resistance of head stud connector is significantly above 400℃, whether the test is done at temperature or post temperature conditions. Also, adding some materials to the concrete mix such as carbon nanotubes will be not effective on the ultimate shear at temperatures less than 400 ℃, but it reduces the spalling and cracking of the concrete. In general, the influence of elevated temperatures on the ultimate shear capacity of the headed stud connector is noticeably clearer when the test was conducted at exposed to certain temperature compared to post temperature conditions (the test is conducted after exposure the specimen to heat and cooling).
Enhancing Building Stability and Seismic Resilience with Water-Added Tuned Mass Dampers
Authors: A. Salh Hayaty , M. Ibrahim Amer
Published: September 2024

These days, the construction industry is increasingly producing buildings with extremely low damping values. Under structural vibrations caused by storms and earthquakes, structures can collapse easily. There are now several methods for reducing structural vibrations, and one of the methods currently employed is the Tuned Mass Damper (TMD). Research is being conducted to determine its performance and importance. The entire damper was tuned for various constructions. An eight-story model specifically designed for the structure was used in this study to observe the structure's response with and without TMD during shaking table experiments. Compared to passive control devices (PTMDs), Active Tuned Mass Dampers (ATMDs) are more efficient as they are active control devices powered externally. By maintaining the structure's frequency, damping, and stiffness constant, other variables such as the percentage reduction in structural capacity can effectively control structure vibrations. The findings and observations from TMD studies can be used to address challenges in earthquake structural control considering current technological limitations and energy demands. The results illustrate significant improvements with damping: the damped structure experienced a 21% increase in acceleration, a 17% increase in velocity, and a 79% reduction in displacement compared to the un damped structure. These findings underscore the effectiveness of damping in mitigating earthquake-induced vibrations.
Effect of Lateral Load to the Behavior of Single Piles Subjected to Earthquake Load in Sand
Authors: H. Ali Hussein , G. Majeed Qutaiba
Published: September 2024

In fact, pile usually carry static and dynamic load in same time, the case of simulations lateral and dynamic load is possible occurred. This case is not cover enough by previous researches especially by laboratory model. Therefore, the purpose of this study is to determine the extent to which altering the horizontal lateral loads impacts the behavior of individual piles during seismic events. An experimental test was devised using a physical model with an advanced shaking table that using El Centro earthquake. Sandy soil with 65% relative density used raining technique. Lateral loads were applied at levels of 0%, 50% and 100% from allowable lateral load capacity. It was observed that when lateral load increased from 0% to 50% and 100%, the lateral displacement response decreased by 32.10% and 49.59% respectively. While the vertical displacement increased by 49.96% and 76.95%. Finally, the acceleration decreased by 34.39% and 41.03%. This is possibly due to the load acts at an angle opposite to the earthquake as a restraining factor for the pile. led to a decrease in lateral displacement, vertical displacement, and peak ground acceleration.
Resilience components of the supply chain in the apparel sector of Pakistan throughout COVID-19
Authors:   School of Business, Amman Arab University, Jordan, Baig Nawaz
Published: September 2024

This study examines the significant impact of COVID-19 on Pakistan's apparel industry, which has faced severe challenges due to global supply chain disruptions and the cancellation of $2.1 billion in export orders by major international buyers. As a key contributor to Pakistan's economy and a major source of employment, especially for women, the apparel sector has been severely strained, with brands like H&M and Walmart reducing business. This has led to factory closures and widespread job losses. Using an explanatory research design and deductive approach, the study focuses on supply chain resilience in the garment sector during the pandemic. Data were collected through a structured questionnaire targeting HR and administrative personnel familiar with company policies and strategies. A sample of 150 respondents was surveyed to assess vulnerabilities, operational sustainability, capabilities, and supply chain resilience. Statistical analyses were conducted using SPSS (version 26), supported by data from newspapers, online sources, and observations. A pilot study confirmed the reliability of the questionnaire. The study highlights the need for greater collaboration among governments, international buyers, and textile organizations to support the industry during crises. It also identifies the health risks faced by workers and emphasizes the importance of policy measures such as stronger labor protections and continued government support. The findings provide valuable insights for policymakers and industry leaders to enhance resilience and sustainability in the global garment industry.
Analysis of the supply chain risk management in pharmaceutical industry
Authors:   Universiti Malaysia Terengganu, Terengganu, Malaysia, Kashif Muhammad
Published: September 2024

This study investigates the escalating complexity and risk in global supply chains, with a particular focus on the pharmaceutical industry. As trade chains become longer and more intricate, the likelihood of disruptions increases, affecting the efficiency and reliability of supply chains. Despite its significance, research on risk management practices specific to the pharmaceutical industry remains limited. This study addresses this gap by evaluating how pharmaceutical companies in Pakistan assess and manage risks. Data were collected through a structured questionnaire distributed to pharmaceutical companies and other industries and analyzed using SPSS. The study, which used a five-point Likert scale and non-probability convenience sampling of 150 to 165 respondents, highlights the impact of supply-related, production-related, and demand-related risks on supply chain operational performance. Findings indicate that addressing these risks through targeted strategies can significantly enhance supply chain management and operational efficiency. The study emphasizes the importance of comprehensive risk assessment and mitigation strategies to improve resilience and performance in the pharmaceutical industry. Limitations include a restricted timeframe and sample size, suggesting the need for further research in different industries and regions to validate and expand on these findings.
A nexus between human capital management and lean supply chain in an organization
Authors:   Faculty of Business, Economy and Social Development, Universiti Malaysia Terengganu, Terengganu, Malaysia, Ali Naveed
Published: September 2024

This study investigates the impact of key human resource management (HRM) practices—learning and development, recruitment and selection, and performance management—on the lean supply chain performance of organizations. A sample size of 100 participants was selected using a simple random sampling technique, targeting individuals with direct experience in both HR and supply chain management. Data were analyzed using SPSS software, applying regression analysis to examine the relationships between variables. The findings provide insights into how HCM contributes to optimizing supply chain performance, offering practical implications for organizations striving for lean supply chain success. The findings confirm the positive influence of these HRM practices on supply chain efficiency and effectiveness. Learning and development (L&D) emerged as critical for fostering continuous improvement and waste reduction in lean supply chains, equipping employees with the necessary skills to support operational excellence. Recruitment and selection were shown to play a fundamental role in hiring individuals aligned with lean principles such as waste minimization and process efficiency. Performance management further contributed by aligning employee performance with lean objectives, ensuring continuous progress in supply chain performance. The study emphasizes the need for strategic integration of HRM practices into lean supply chain initiatives for sustained organizational competitiveness. Limitations include a small sample size, highlighting the need for future research to expand the respondent pool and explore additional organizational development tools to better define the connection between human capital management and lean supply chains.
A case study of Pakistan’s exports in post COVID-19 scenario
Authors:   Iqra University, Pakistan, Aslam Muhammad
Published: September 2024

This paper explores the crucial role exports play in Pakistan's economic growth, particularly amidst the disruptions caused by the COVID-19 pandemic. Exports are essential for earning foreign exchange, maintaining current account balance, and driving economic development. However, Pakistan has consistently declined its export-to-GDP ratio since 2014, leading to economic instability. The COVID-19 pandemic worsened these issues, causing supply chain disruptions and a drop in global demand. This study assesses Pakistan's export performance before and after the pandemic, evaluates the pandemic’s impact on trade, and offers recommendations for fostering export-led growth in the post-pandemic period. It also highlights the significant 10% economic loss in FY2021, with major trading partners like the USA, China, and Germany facing severe impacts. Despite challenges, Pakistan's textile and leather sectors grew in areas such as surgical instruments. A survey of 149 respondents showed statistically significant relationships between key variables and government policies like tax waivers and reduced utility costs, which helped revive industries, particularly textiles, creating jobs and boosting exports. The study recommends diversifying low-cost products and enhancing export strategies to recover lost trade. However, limitations such as a small sample size and limited resources suggest that future research is needed to expand on these findings.
Colonized Body Of Women In Ahmad Tohari’s Novel The Dancer
Authors: Rarastesa Zita
Published: September 2024

This study aims to analyze how the female body is colonized in Ahmad Tohari's novel "The Dancer." The novel portrays the lives of women in Javanese culture, shaped by colonialism and patriarchy, and illustrates how the female body becomes a site of domination, control, and exploitation. Utilizing a postcolonial feminist perspective, this research examines the experiences of physical, psychological, and social oppression faced by the female characters in the novel and their responses to various forms of colonization of their bodies. The findings reveal that through narrative and characterization, Ahmad Tohari explores the complexities of female identity influenced by colonial history and patriarchal structures. These findings highlight the importance of understanding the female body as a battleground between dominant forces and women's resistance against various forms of oppression. Thus, this study contributes to the broader discourse on gender and colonialism studies in Indonesian literature.
Efektifitas Rebusan Air Daun Sirih Dalam Perawatan Dermatitis Dalam Konsep Asuhan Keperawatan di Kelurahan Pandan Kasturi RT/RW: 01/01 Kecamatan Sirimau Kota Ambon
Authors: Lombonanung Ellen
Published: September 2024

Occupational skin disease is a skin disorder that occurs due to a person's work and is commonly found in industrial, agricultural, and plantation areas. This disease is caused by materials/substances and processes carried out in the workplace generally and is known as dermatitis. Atopic dermatitis has dry skin and often has itching, allergic rhinitis, nasal obstruction, conjunctiva and pharynx itching, lacrimation, and seasonality when associated with pollen. This study uses a descriptive case study method where the researcher will describe the case experienced by a client with dermatitis. Respondents in this case study were Mr. N who has been experiencing dermatitis for ± 2 weeks in the pandan kasturi village RT / RW: 01/01 which was carried out for 3 days (November 27, 2023-30 November 2023). The results showed that during the 3 days of implementing dermatitis treatment with siri leaf decoction water, there were changes from Mr. N's complaints. Mr. N said the itching on his feet and hands and between his fingers decreased, did not feel itchy at night after treatment with siri leaf decoction water, redness and wounds due to frequent scratching seemed to decrease. It can be concluded that betel leaf cooking water is effective for the treatment of itching in dermatitis.
Küçük Hücreli Dışı Akciğer Kanseri Olgularında Torasik Radyoterapinin Yaşam Kalitesine Etkisinin Değerlendirilmesi
Authors: Korkmaz Kirakli Esra , Erdiş Eda , Erim Eser , Zoto Teuta , Atalar Banu , Yücel Birsen
Published: September 2024

Amaç: Çalışmamızın birincil amacı Küçük Hücreli Dışı Akciğer Kanseri (KHDAK) tanısıyla radikal amaçlı torasik Radyoterapi (TRT) uygulanan olgularda, torasik RT’nin yaşam kalitesi skorları üzerinde yaptığı değişiklikleri saptamak, ikincil amacı ise RT parametrelerinin yaşam kalitesi skorlarına etkisini araştırmaktır.
Gereç ve Yöntem: Çalışmaya katılan 3 ayrı merkezde Temmuz 2018-Temmuz 2019 tarihleri arasında radikal torasik RT uygulanan Küçük Hücreli Dışı Akciğer Kanseri olguları çalışmaya dahil edilmiştir. RT öncesinde, RT sonunda ve RT’den 1 ay sonra genel (QLQC30) ve akciğer kanserine spesifik (QLQ-L13) yaşam kalitesi anket modülleri ile yaşam kalitesi verileri toplanmış ve bu parametrelerdeki değişimler değerlendirilmiştir. Ayrıca RT tekniği, total doz, planlanan hedef hacim, dozimetrik veriler ile yaşam kalitesi skorlarındaki oluşan değişiklikler arasındaki ilişkisi araştırılmıştır.
Bulgular: Verileri analiz edilen olgu sayısı 124’tü. Ankete uyum oranı %88’di. Ortanca yaş 61 (54-65)’di. Olguların %90’ı erkek, %84’ü evre 3’tü. Olguların %46’sında 3 Boyutlu Konformal Radyoterapi, %54’ünde Yoğunluk Ayarlı RT tekniği uygulanmıştı. Eşzamanlı KT alan olgu sayısı 72 (%58)’ydi. Radikal torasik RT ile olguların genel yaşam kalitesi skorları değişmezken, RT bitiminde, RT öncesi ve sonrasında 1. aya göre; emosyonel fonksiyon azalmakta, disfaji, halsizlik, bulantı-kusma ve iştah kaybında anlamlı artış oluşmaktaydı. Hemoptizide ise anlamlı palyasyon RT sonrası 1. ayda sağlanmaktaydı. Klinik parametreler ve RT ilişkili parametreler ile yaşam kalitesi skorlarında oluşan değişiklikler arasında bir ilişki bulunamamıştır.
Sonuç: Radikal torasik RT’nin bitiminde olguların genel yaşam kalitesi değişmezken, emosyonel fonksiyon düşmekte, disfaji, halsizlik, bulantı-kusma ve iştah kaybında anlamlı artış oluşmakta, hemoptizide ise anlamlı palyasyon sağlanmaktadır. RT ilişkili parametreler ile yaşam kalitesi skorlarında oluşan değişiklikler arasında bir ilişki bulunamamıştır.
Cervical Spondylosis Severity and Its Correlation with Clinical Parameters and Cervical Lesions in Multiple Sclerosis: A Cross-Sectional MRI Study
Authors: Jamalipour Soufi Ghazaleh , Hekmatnia Ali , Shaygannejad Vahid , Rezaei Mohammad Reza , Khanifar Hadi , Chitsaz Navid
Published: September 2024

Background: The co-occurrence of multiple sclerosis (MS) and cervical spondylosis (CS) may not only intensify symptoms but also complicate the management of these disorders. Magnetic resonance imaging (MRI) is the preferred modality for detecting spinal cord lesions; however, there is limited evidence assessing myelopathy in concurrent CS and MS. Objectives: This study aims to evaluate the association between CS and its effects on the spinal cord, as well as their impact on enhancing MS cervical lesions. Methods: This cross-sectional study was conducted on 104 MS patients between 2019 and 2021. Data collected included age, gender, duration and phenotype of MS, and the Extended Disability Status Scale (EDSS). Magnetic resonance imaging images were obtained and analyzed for the presence of cervical spondylosis and demyelinated cervical plaques (active/inactive). Multiple sclerosis plaques were evaluated based on their extension, enhancement, and cervical location. Cervical spondylosis was categorized into four grades using the Muhle scale. Additionally, the spinal cord cross-sectional area (SC - CSA) was measured at the C2 - C3 cervical spine level. Results: The severity of cervical spondylosis was associated with older age (P-value < 0.001), longer duration of MS (P-value = 0.04), more severe EDSS scores (P-value = 0.03), and a lower C2 - C3 CS-CSA (P-value < 0.001). However, no significant associations were found with gender (P-value = 0.90), MS plaques activity (P-value = 0.25), or extension (P-value = 0.13). Conclusions: The study findings indicate that the severity of CS is associated with age, MS duration, EDSS, and the C2 - C3 cervical spine cross-sectional area. However, the study did not find evidence supporting a relationship between CS and the extension or activity of MS plaques.
Mini Review: Antimicrobial Agents Based on Natural Compounds: The Key to Solving the Current Crisis
Authors: Pouran Fatemeh , Mahdavian Amirmohsen , Aghazadeh Hossein , Navidinia Masoumeh
Published: September 2024

Context: The rapid development of resistance mechanisms by bacteria has led to the loss of effectiveness of many commonly used antibiotics, posing a serious threat to global public health. Therefore, the objective of this study is to provide further insights into combating antibiotic resistance and addressing the urgent need for additional effective antimicrobial treatments as alternatives. Methods: In this narrative review, natural compounds derived from plants, fungi, and other sources were evaluated for their antimicrobial properties based on clinical trials and in vitro studies. These compounds have gained attention due to their potential to serve as alternative or adjunctive therapies. Results: We briefly reviewed and introduced antibacterial agents derived from natural substances and extracts as an alternative solution to the current crisis. Many natural sources, such as antimicrobial peptides (AMPs), nanoparticles, enzyme disruption of acylhomoserine lactones (AHLs), Mur enzymes, lysocine E, plant-derived natural products, polyphenols, nanozymes, antimicrobial peptidomimetics, and antimicrobials of fungal origin (such as penicillin, griseofulvin, amphotericin B, echinocandins, and statins), produce a wide range of secondary metabolites with the potential to exhibit antibacterial activity. Moreover, natural products often possess complex chemical structures, which can target multiple bacterial pathways, enhancing their ability to inhibit or kill bacteria. Conclusions: This study contributes new knowledge and perspectives on combating antibiotic resistance by exploring alternative treatments and natural products, which represent an important area of research. It may offer new solutions to address the urgent need for effective antimicrobial treatments. Further research is necessary to isolate, identify, and characterize the active compounds, study their mechanisms of action, optimize their efficacy and safety, and evaluate their potential for clinical use.
The Role of Nurses in Delivering Bad News to the Patient and Family: An Integrated Review Study
Authors: Khaki Soore , Fallahi-Khoshknab Masoud , Mohammadi-Shahboulaghi Farahnaz , Can Gülbeyaz , Hosseini Mohammadali
Published: September 2024

Background: Since nurses play a central role in communicating with physicians, patients, and patients' families, special attention should be paid to their role in delivering bad news. Objective: This review aims at describing and highlighting the role of nurses in announcing bad news to patients and families. Methods: This was an integrated review. To collect data, a literature search was conducted in the Persian and English databases of Magiran, Scientific Information Base (SID), Scopus, Google Scholar, Web of Science, and PubMed. Eligibility criteria included publishing in English and Persian between January 1, 1980, and January 1, 2022, describing the role of nurses in delivering bad news to the patient and family. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were used to screen and select relevant studies. Critical appraisal tools provided by the Joanna Briggs Institute (JBI) were used for quality assessment. The collected data were analyzed, using constant comparative methods. Results: Of the 453 unique records screened, only 26 met the eligibility criteria. The results show that delivering bad news is a team process, in which nurses have several roles. Their main roles were classified into 4 categories: Manager, facilitator, educator, and supporter/advocate, and 74 subordinate roles. Conclusions: The role of nurses in delivering bad news to patients and their families is important. Their behavior and communication skills significantly affect how they receive this news. Neglecting the role of nurses in this process can damage the patient's trust and understanding of the quality of care. Therefore, nurses should be trained in delivering bad news and supporting patients and families in difficult situations.
Do Parental and Children’s Dental Anxiety Affect Childhood Dental Caries?
Authors: Samami Mohammad , Mahjoub Khatibani Seyedeh Porousha , Alian Zohre , Mohammaditabaar Mohammad Sadegh , Hosseini Moghaddam Emami Foroughossadat , Hassanzadeh Rad Afagh
Published: September 2024

Background: Dental anxiety is an unpleasant reaction to fear or stress related to the dental environment and can be observed in both parents and children as dental patients. Despite several studies challenging the significance of parental anxiety in influencing a child's response to dental treatment, conflicting results have emerged regarding the impact of both parental and children's anxiety on the development of dental caries. Objectives: This study aimed to explore the association between parental and children's dental anxiety and the occurrence of dental caries in children. Methods: A cross-sectional study involving 7 - 12-year-old students and their parents in schools of Rasht, Iran, utilized the Modified Dental Anxiety Scale (MDAS) for parents and the Modified Child Dental Anxiety Scale (MCDAS) questionnaire for children. Participants were chosen through a multistage sampling process. A trained dentist assessed children's dental caries using the DMFT/dmft (decayed, missing, and filled teeth) Index. The data were analyzed using the chi-square test and linear regression. Results: The study included 275 parents and an equal number of children, with a mean child age of 9.32 ± 1.85 years. The findings indicated a significant relationship between maternal dental anxiety and DMFT + dmft scores in boys (P = 0.049). The study revealed that the number of teeth with caries experience (P = 0.023), child's sex (P = 0.007), history of dental clinic visits (P = 0.045), and maternal dental anxiety (P = 0.043) significantly influenced the child's dental anxiety. Conclusions: Children with anxious parents showed lower DMFT/dmft values, suggesting increased attention to their dental health. The study highlights the impact of parental dental anxiety on children's oral well-being and emphasizes the need for comprehensive strategies to address dental anxiety in both parents and children.
A Comparative Analysis of the Frequency of Bipolar Spectrum Disorder in Patients with and Without Psoriasis
Authors: Banihashem Seyedshahab , Moayed Mortazavi Seyed Ahmad , Shahidi Dadras Mohamad , Samimi Ardestani Mehdi , Zahedi Khatere , Sarani Yaztappeh Jafar
Published: September 2024

Background: Psoriasis is a chronic disease that significantly negatively affects a patient’s quality of life. Based on etiopathological characteristics, there is strong evidence of susceptibility to psychological disorders, such as depression and bipolar disorder, in patients suffering from psoriasis. Objectives: We investigated the frequency of bipolar spectrum disorders in psoriasis patients compared to healthy controls in a selected population in Iran. Methods: This case-control study was conducted on two sample groups, with and without psoriasis (50 people in each group). The statistical population included all individuals referred to Shohadaye Tajrish and Taleghani Hospitals of Shahid Beheshti University of Medical Sciences, selected using the available method and assigned to two groups in 2023. The participants were examined for the presence of bipolar spectrum disorders using the Mood Disorder Questionnaire (MDQ) and the Bipolar Spectrum Diagnostic Scale (BSDS). Results: According to the MDQ questionnaire, the frequency rates of bipolar disorder in the patients and controls were 20% and 40%, respectively, with no significant difference between the groups (P = 0.108). Based on the BSDS, the frequency of bipolar disorder in the two groups, with and without psoriasis, was estimated to be 25% and 32.1%, respectively, with no significant difference (P = 0.226). The rate of major depressive disorders was also 22% and 26%, with no significant difference (P = 0.640). Conclusions: Among Iranian patients with psoriasis, the presence of the disease may not be associated with an increased risk of bipolar spectrum disorders.
The Role of Zinc Supplementation in Alleviating Inflammatory Biomarkers in Patients Undergoing Hemodialysis: A Randomized Placebo Controlled, Crossover Trial
Authors: Mastoor-Tehrani Shayan , Samadian Fariba , Esmaily Hadi , Kargar Alireza , Markazi Nasim , Anvari Shideh , Ziaie Shadi
Published: September 2024

Background: Chronic kidney disease (CKD), which progresses to end-stage renal disease (ESRD) and requires maintenance hemodialysis (MHD), is a global health issue. Inflammation in MHD patients is associated with increased mortality and cardiovascular events. Zinc, essential for immune function and possessing anti-inflammatory properties, is frequently deficient in these patients and could potentially help mitigate inflammation. Objectives: This study aims to assess the impact of zinc supplementation on inflammatory biomarkers, specifically (CRP) and the neutrophil-to-lymphocyte ratio (NLR), in MHD patients. Methods: In a double-blind, randomized controlled crossover trial conducted at Labafinejad Hospital, Tehran, MHD patients with zinc deficiency were initially allocated to either a zinc supplementation group or a placebo group. After 30 days, the groups were crossed over, with patients initially receiving zinc now receiving a placebo and vice versa. The primary outcome was changes in serum zinc levels, while secondary outcomes focused on CRP and NLR levels. Results: Significant changes in serum zinc levels were observed in both groups from baseline to Month 2 (drug-placebo group: Mean change -15.9±10.33 µg/dL, P < 0.05; placebo-drug group: Mean change -14.70 ± 12.58 µg/dL, P < 0.05). A significant initial reduction in CRP levels at Month 1 (P = 0.045) was not sustained at Month 2 (P = 0.812). No statistically significant changes in NLR were noted. Improvements in quality of life, including reductions in muscle pain and skin dryness, were significant in the drug-placebo group (P < 0.05). Conclusions: Zinc supplementation in MHD patients significantly improved serum zinc levels and initially reduced CRP levels, highlighting its potential role in managing inflammation. Although the impact on NLR was not significant, overall patient outcomes and quality of life showed promising improvements.
Inhibitory Effects of Marrubium vulgare L. Extract on the Female Hormones Based on Bioautography-HPTLC-MS
Authors: Hassannejad Sahar , Sarmamy Abdulghany O. I. , Mirzajani Fateme
Published: September 2024

Background: Hormonal imbalances related to women's health, physical activity, and fluctuations are prevalent metabolic disorders in several nations and have significantly impacted women's health for an extended period. The application of individual or combined botanical extracts in traditional, alternative, and complementary medicine is employed to manage and alleviate these issues. Objectives: The objective of this study is to examine the suppressive properties of horehound (Marrubium vulgare L.) on pivotal hormones associated with feminine disorders. Methods: The horehound plant was exposed to ultrasonic radiation while five different solvents (methanol, ethyl acetate, n-hexane, acetone, and water) were used to extract its components. The individuals were isolated using high-performance thin-layer chromatography (HPTLC). The most powerful compounds were analyzed using a direct antioxidant assay (DPPH test) and a hormone inhibitory assay (Oestrogen, Progesterone, Estradiol, and Testosterone) on the HPTLC plate. The compounds that had a significant effect were then identified using LC-ESI/MSMS. Results: The antioxidant properties of the extracts and hormone inhibitors were evaluated, and the substances were separated from the HPTLC plate and analyzed using mass spectrometry. The results showed strong antioxidant capabilities, with an IC50 range of 8.24 - 12.42 µg/mL. Moreover, the plant extract showed beneficial effects on hormones associated with female health issues. Conclusions: The extract was subjected to chemical and molecular analysis using the HPTLC technique, followed by LC-ESI/MSMS. The study revealed the presence of vulgarole, marrubiin, and marrubenol chemicals.
Therapeutic Potential of Crocin and Nobiletin in a Mouse Model of Dry Eye Disease: Modulation of the Inflammatory Response and Protection of the Ocular Surface
Authors: Habibian Sezavar Ahmad , Ostad Seyed Nasser , Hasani Nourian Yazdan , Aghamollaei Hossein
Published: September 2024

Background: Dry eye disease (DED) is a multifactorial condition characterized by ocular surface inflammation, tear film instability, and corneal epithelial damage. Current treatments often provide temporary relief without addressing the underlying inflammatory mechanisms. Objectives: This study examined the therapeutic potential of crocin and nobiletin, two naturally derived compounds with well-known antioxidant and anti-inflammatory properties, in a mouse model of DED induced by lacrimal gland excision (LGE). Methods: Thirty female Balb/c mice were divided into five groups (n = 6 each): Control (sham surgery), untreated DED, nobiletin-treated DED (32.75 µM), crocin-treated DED (34 µM), and 1% betamethasone-treated DED. Treatments were administered three times daily for 28 days. Ocular tissues were evaluated using Hematoxylin and Eosin (H&E) staining and fluorescein staining. Conjunctival inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α), were measured by enzyme-linked immunosorbent assay (ELISA). Results: Histological analysis showed that the crocin and nobiletin treatment groups exhibited reduced epithelial disruption, keratinization, and inflammatory cell infiltration compared to the untreated DED group. The ELISA assay revealed that both compounds efficiently inhibited the production of the pro-inflammatory cytokines IL-6, TNF-α, and IL-1β, which are key mediators of DED pathogenesis. Fluorescein staining further confirmed the protective impact of crocin and nobiletin on corneal epithelial integrity. Moreover, the anti-inflammatory and epithelial-preserving effects of these compounds were comparable to those of the corticosteroid betamethasone. Conclusions: Overall, these findings suggest that crocin and nobiletin have therapeutic potential for DED management by modulating inflammatory responses and enhancing ocular surface healing. These naturally derived compounds offer promising avenues for the development of safer and more effective treatments for this challenging condition. However, further investigations, including clinical trials, are essential to elucidate the underlying mechanisms of action and optimize therapeutic approaches.
Assessment of Healthcare Service Quality and Patient Satisfaction Using the SERVQUAL Questionnaire in Khuzestan Province During 2022 - 2023
Authors: Hosseinzadeh Mofid , Pouladzadeh Mandana , Eskandari Ahmad
Published: September 2024

Background: Hospital service quality is the primary predictor of a hospital's success, and any decrease in patient satisfaction is a cause for concern for the organization. Objectives: This study aimed to evaluate the service quality of Golestan Hospital in Ahvaz, Iran, based on patient satisfaction measured using the SERVQUAL questionnaire. Methods: This cross-sectional study was conducted in 2022 - 2023. Patients over 18 years old who visited the emergency department at Golestan Hospital were evaluated, with the exception of those with mental or multiple chronic disorders. Data collection tools included demographic and SERVQUAL Questionnaires. The data were analyzed using SPSS software, with a significance level set at less than 0.05. Results: A total of 200 subjects participated in the study, comprising 124 females (62%) and 76 males (38%). The results of the SERVQUAL Questionnaire indicated that the highest score was in the tangibility dimension (4.35), while the lowest score was in the assurance dimension (1.38). Negative gaps between perception and expectation were observed in the responsiveness (-0.99) and empathy (-1.22) dimensions. The mean total scores for expectation and perception were 99.55 ± 5.06 and 92.85 ± 5.5, respectively, with the highest scores observed for reliability. No significant association was found between expectation and perception (P-value > 0.05). However, the reliability of the gap and expectation in males was significantly higher (P-value < 0.05). A direct correlation was found between age and tangibility, Assurance, and total score of gaps (P-value < 0.05). Conversely, a reverse correlation was observed between age and tangibility and the total score in perception (P-value < 0.05). Post-hoc analysis revealed that the Assurance and total score of gaps and expectations were significantly higher in married patients compared to single patients (P-value < 0.05). Conclusions: This study revealed a negative gap between patients' expectations and perceptions, highlighting the need for adjustments and improvements in hospital service quality by addressing all five dimensions of service quality.
Gallbladder Necrosis Following Fenestrated Endovascular Aneurysm Repair
Authors: Saif El Hak El Hadhri , Nazih Chaouch , Benjamin Hentgen , Khawla Boughanmi , Fallouh Ahed
Published: September 2024

: Fenestrated endovascular aortic repair of aneurysms with challenging necks has advanced significantly over the last three decades. In cases with extremely hostile proximal necks, such as the one described here (a common trunk between the superior mesenteric artery and the celiac artery), it may be necessary to cover the celiac trunk to ensure better graft attachment and avoid endoleaks. However, unexpected events can still occur, even with collateral circulation present. To our knowledge, this is the second reported case of gallbladder necrosis following fenestrated endovascular aortic repair.
The health status of esports athletes: challenges and striving for solutions
Authors: Мирошниченко М.А.
Published: September 2024

в последние десятилетия киберспорт стал одной из самых быстрорастущих индустрий в мире развлечений. Что начиналось как простое хобби для компьютерных энтузиастов, превратилось в многомиллиардную индустрию, привлекающую миллионы зрителей и спонсоров по всему миру. В основе киберспорта лежит соревновательная игра в видеоигры на профессиональном уровне. Дисциплины киберспорта включают в себя такие игры, как Dota 2, League of Legends, Counter-Strike, Overwatch и многие другие. Киберспортсмены уделяют огромное количество времени тренировкам, анализу своей игры и состязаниям на турнирах. Статья рассматривает состояние здоровья киберспортсменов, выявляет основные вызовы, с которыми они сталкиваются, и предлагает пути решения этих проблем. Исследуются физические и психологические нагрузки, связанные с интенсивными тренировками и соревнованиями, а также распространённые заболевания и расстройства, характерные для данной профессиональной группы. Особое внимание уделяется мерам профилактики и реабилитации, включая рекомендации по организации режима труда и отдыха, физическим упражнениям и психологической поддержке. В заключение подчёркивается необходимость комплексного подхода к охране здоровья киберспортсменов для обеспечения их долговременной профессиональной активности и высокого уровня спортивных достижений.

in recent decades, esports has become one of the fastest-growing industries in the entertainment world. What began as a simple hobby for computer enthusiasts has turned into a multibillion-dollar industry attracting millions of viewers and sponsors worldwide. At the core of esports is competitive gaming at a professional level. Esports disciplines include games such as Dota 2, League of Legends, Counter-Strike, Overwatch, and many others. Esports athletes dedicate a huge amount of time to training, analyzing their gameplay, and competing in tournaments. This article examines the health status of esports athletes, identifies the main challenges they face, and proposes solutions to these problems. It explores the physical and psychological stresses associated with intensive training and competitions, as well as common diseases and disorders characteristic of this professional group. Special attention is given to preventive and rehabilitative measures, including recommendations on organizing work and rest schedules, physical exercises, and psychological support. In conclusion, the necessity of a comprehensive approach to the health protection of esports athletes is emphasized to ensure their long-term professional activity and high level of sporting achievements.
Values of business culture of Iraqi Kurdistan
Authors: Ахмед Ю.А.А.
Published: September 2024

Иракский Курдистан на сегодняшний день активно развивается. Формируются отношения Российской Федерацией и Иракского Курдистана в области добычи, переработки и транспортировки нефти и газа. Масштабные инвестиции в Иракский Курдистан являются важным признаком силы «курдской карты» в геополитике, а курдская экономика – важным источником иностранных инвестиций в Иракский Курдистан. Поэтому, изучение ценностей деловой культуры Иракского Курдистана на сегодняшний день имеет большое значение, т.к. позволит понять специфику региона и особенности ведения бизнеса. В настоящей статье рассмотрены ключевые ценности деловой культуры иракских курдов, и истоки их формирования. Отмечено влияние обычаев и религии на Иракский Курдистан, представлены факторы, способствующие формированию конкретной ценности. В настоящее время на повестке дня для Иракского Курдистана и других регионов стоит вопрос об укреплении общепринятых требований к деловому общению, этикету и соблюдению этических норм с целью расширения.

Iraqi Kurdistan is currently actively developing. Relations between the Russian Federation and Iraqi Kurdistan are being formed in the field of oil and gas production, processing and transportation. Large–scale investments in Iraqi Kurdistan are an important sign of the strength of the "Kurdish map" in geopolitics, and the Kurdish economy is an important source of foreign investment in Iraqi Kurdistan. Therefore, studying the values of the business culture of Iraqi Kurdistan is of great importance today, because it will allow you to understand the specifics of the region and the specifics of doing business. This article examines the key values of the business culture of the Iraqi Kurds, and the origins of their formation. The influence of customs and religion on Iraqi Kurdistan is noted, and the factors contributing to the formation of a specific value are presented. Currently, the issue of strengthening generally accepted requirements for business communication, etiquette and compliance with ethical standards is on the agenda for Iraqi Kurdistan and other regions in order to expand.
Features of the use of modern digital technologies to optimize logistics processes
Authors: Ли Ш. , Сюе В.
Published: September 2024

в современном понимании логистические процессы выступают в качестве ключевой основы многочисленных отраслей промышленности, обеспечивая эффективный поток товаров и услуг от производства к потреблению. Важно подчеркнуть, что понятие логистики охватывает достаточно обширный спектр разновидностей деятельности – речь идёт о закупках, транспортировке, управлении запасами, складировании, распределении, обработке возвратов. Целевым ориентиром служит полноценное обеспечение того, чтобы нужный продукт находился в требуемом месте, в конкретное время и в должном состоянии, при этом минимизируя затраты и поддерживая высокую эффективность. В нынешних условиях актуальность изучения особенностей применения современных цифровых технологий для оптимизации логистических процессов связана с необходимостью снижения себестоимости продукции, обеспечения потребителей услугами, развития интеллектуальных систем, повышения эффективности управления закупками, цепями поставок, хранением, а также совершенствования электронной коммерции. Целью в данной статье служит исследование современных представлений о специфике использования цифровых технологических решений для оптимизации процессов в логистике (с выделением проблем в данной сфере). Ключевая проблема заключается в необходимости адаптации и интеграции этих технологий в существующие логистические системы. Это требует значительных инвестиций, времени, ресурсов, а также способно вызвать мощное сопротивление со стороны сотрудников и руководящего звена хозяйствующих субъектов.

in the modern understanding, logistics processes act as a key basis for numerous industries, ensuring an efficient flow of goods and services from production to consumption. It is important to emphasize that the concept of logistics covers a fairly wide range of types of activities – we are talking about procurement, transportation, inventory management, warehousing, distribution, and return processing. The goal is to fully ensure that the desired product is in the right place, at a specific time and in proper condition, while minimizing costs and maintaining high efficiency. In the current conditions, the relevance of studying the features of the use of modern digital technologies to optimize logistics processes is associated with the need to reduce the cost of production, provide consumers with services, develop intelligent systems, improve the efficiency of procurement management, supply chains, storage, as well as improve e-commerce. The purpose of this article is to study modern ideas about the specifics of using digital technological solutions to optimize processes in logistics (highlighting problems in this area). The key problem is the need to adapt and integrate these technologies into existing logistics systems. This requires significant investments, time, resources, and can also cause strong resistance from employees and senior management of business entities.
Conceptual shifts in the system of macroeconomic reproduction in the context of digital economy formation
Authors: Сахбиева А.И.
Published: September 2024

целью статьи является исследование и описание изменений в системе макроэкономического воспроизводства, обусловленных переходом к цифровой экономике. Автор стремится выявить ключевые тенденции, процессы и последствия цифровизации для глобальной экономической системы, а также определить как эти изменения влияют на стабильность и устойчивое развитие экономики на различных уровнях. Исследование показывает, что цифровая трансформация приводит к значительным изменениям в макроэкономическом воспроизводстве, включая ускорение процессов создания добавленной стоимости и изменение структуры глобального капитала. Автор выявляет ряд проблем и вызовов, таких как усиление социального расслоения, возрастание фиктивного капитала и риски глобальных финансовых нестабильностей. В статье обсуждаются возможные пути смягчения негативных последствий цифровизации и подчеркивается необходимость формирования новой методологии и системы общественных ценностей, способных адаптироваться к изменяющейся экономической ситуации.

the aim of the article is to investigate and describe the changes in the system of macroeconomic reproduction caused by the transition to the digital economy. The author seeks to identify the key trends, processes and consequences of digitalization for the global economic system, as well as to determine how these changes affect the stability and sustainable development of the economy at various levels. The study shows that digital transformation leads to significant changes in macroeconomic reproduction, including the acceleration of value-added processes and changes in the structure of global capital. The author identifies a number of problems and challenges, such as increasing social stratification, growing fictitious capital and risks of global financial instability. The article discusses possible ways to mitigate the negative consequences of digitalization and emphasizes the need to form a new methodology and a system of social values capable of adapting to the changing economic situation.