bluuebunny/crossref_metadata_2025 huggingface dataset:
CT-Based Software-Generated Measurements Permit More Objective Assessments of Arithmetic Hip-Knee-Ankle Axis and Joint Line Obliquity
Authors: Wong Wai Kit , Zulkhairi Siti Zubaidah , Chua Hwa Sen
Published: January 2025

The rapid adoption of robotic-assisted total knee arthroplasty (RATKA) has resulted in pre-operative CT scans becoming more readily available. After the segmentation and identification of landmarks by trained segmentation specialists, the Mako SmartRoboticsTM software generates measurements of interest for the calculation of the arithmetic hip-knee-ankle axis (aHKA), joint line obliquity (JLO), and the Coronal Plane Alignment of the Knee (CPAK) phenotype. The aim of this study is to ascertain how closely correlated these two sets of readings are and whether the CPAK distribution is altered when comparing both modalities. A retrospective radiological study was undertaken on 500 knees (367 patients: 133 bilateral, 234 unilateral) comparing the CT-based software-generated measurements of patients undergoing RATKA using the Stryker Mako system against manual measurements derived from long limb radiographs (LLRs). There were statistically significant differences between the average measurements of the LDFA (0.27 ± 2.95, p = 0.045), MPTA (1.15 ± 2.20, p < 0.001), aHKA (1.41 ± 3.85, p < 0.001) and JLO (0.89 ± 3.50, p < 0.001), with CT measurements having higher mean readings for LDFA, lower readings for MPTA, more varus aHKA and increased apex distal JLO. Despite this, correlation was moderately good: LDFA (r = 0.409, p < 0.001), MPTA (r = 0.683, p < 0.001), aHKA (r = 0.595, p < 0.001) and JLO (r = 0.456, p < 0.001). The CPAK distribution was also significantly different. LLRs underestimate the degree of constitutional varus and JLO compared to CT-based software-generated measurements, with a resultant increase in CPAK Types I and IV when using CT measurements. Despite moderately good correlation between both imaging modalities, there remains a statistically significant difference between them.
The Tribological Reduction Mechanism of the Rubber Hexagonal Surface Texture of the Screw Pump Stator
Authors: Hao Zhongxian , Wei Songbo , Jia Deli , Yang Qinghai , Niu Xinglong , Zheng Gang , Zhu Shijia , Liu Xinfu
Published: January 2025

This paper develops a composite weaving structure, combining hexagonal micro-bumps and hexagonal grooves, in the design of the rubber surface of the screw pump. This allows us to solve the problem of high torque and fast wear of the rubber stator during the operation of screw pump lifting oil recovery, based on the bionic hexagonal surface structure, traditional surface damping principle, and fluid dynamic pressure lubrication theory. Finite element analysis is first conducted to quantitatively analyze the impacts of the parallel side distance, groove width, and groove depth on the surface flow field and wall pressure field of the composite hexagonal structure. Based on the simulation law, the rubber surface laser structure is then designed and prepared by nanosecond laser processing. Afterward, tribological experiments are conducted under the condition of long-term immersion in the actual extraction fluid of shale oil wells. This aims at simulating the actual downhole oil production conditions and quantitatively studying the impact of the size of the composite hexagonal structure on the lubrication characteristics of the friction part of the stationary rotor, as well as the effect of abrasion reduction. The results show that, within the simulation range, the smaller the parallel side distance, the higher the load-carrying capacity. In addition, the hexagonal weave with a parallel side distance of 3 mm has a higher wall load carrying capacity than that with distances of 4 mm and 5 mm. When the groove width is equal to 0.4 mm, the oil film load carrying capacity is higher than that in the case of 0.2 mm. When the groove depth increases, the oil film pressure first increases and then stabilizes or decreases after reaching 0.3 mm. In the hexagonal weave, the friction ratio of the rotor is equal to 0.4 mm. In the tribological experiment of hexagonal weave, the smaller the parallel side distance, the smaller the friction coefficient, and the 0.5 mm weave has the highest performance.
Metal Additive Manufacturing: Design, Performance, and Applications
Authors: Kladovasilakis Nikolaos , Tsongas Konstantinos , Tzetzis Dimitrios
Published: January 2025

The rapid evolution of metal additive manufacturing (AM) has led to transformative advancements across various industries, including aerospace, healthcare, automotive, and energy [...]
Microstructure and Corrosion Behaviors of Gas Tungsten Arc Welds for Borated Stainless Steel Using Various Filler Metals
Authors: Seo Minseok , Nam Hyunbin , Yoon Yongju , Kang Namhyun , Park Cheolho
Published: January 2025

In this study, the microstructure and corrosion behavior of gas tungsten arc (GTA) welds of borated stainless steel (BSS) with a boron content of 1.62 wt.% were investigated using various filler metals. The filler metals used in this study were 308L, 309L, and 310 without the B component. A small amount of the B component was observed in the weld metal (WM) of all specimens, even though none of the filler wires contained boron. This result was caused by the dilution of the B component from the BM into the WM by the welding heat. The segregation of boron in the WM resulted in Cr-depleted areas, which negatively affected the corrosion resistance of the welded specimens. The corrosion resistance of 308L WM with the highest fraction of B components was the most deteriorated, whereas 309L WM with the lowest boron content exhibited the best corrosion resistance. Using a filler metal without the B component is expected to effectively improve the weldability and corrosion resistance of BSS; however, it can also reduce the neutron absorption capacity. Therefore, for BSS to be used as a spent nuclear fuel storage container material, the boron content of the filler metal must be carefully considered. This study provides a foundation for research aimed at improving the development and applicability of filler metals in borated stainless steel and makes it competitive for application in fourth-generation nuclear power systems.
Improving Corrosion and Wear Resistance of 316L Stainless Steel via In Situ Pure Ti and Ti6Al4V Coatings: Tribocorrosion and Electrochemical Analysis
Authors: Alontseva Darya , Yavuz Hasan İsmail , Azamatov Bagdat , Khoshnaw Fuad , Safarova (Yantsen) Yuliya , Dogadkin Dmitriy , Avcu Egemen , Yamanoglu Ridvan
Published: January 2025

This study aims to achieve in situ-formed pure Ti and Ti6Al4V coatings on 316L stainless steel through hot pressing and examine their wear and corrosion properties thoroughly in two simulated body fluids: physiological serum (0.9% NaCl) and Hanks’ solution. The sintering and diffusion bonding process was conducted at 1050 °C under a uniaxial pressure of 40 MPa for 30 min in a vacuum environment of 10−4 mbar. Following sintering, in situ-formed pure Ti and Ti6Al4V coatings, approximately 1000 µm thick, were produced on 316L substrates approximately 3000 µm in thickness. The mean hardness of 316L substrates, pure Ti, and Ti6Al4V coatings are around 165 HV, 170 HV, and 420 HV, respectively. The interface of the stainless steel substrate and the pure Ti and Ti6Al4V coatings exhibited no microstructural defects, while the interface exhibited significantly higher hardness values (ranging from 600 to 700 HV). The coatings improved corrosion resistance in both electrolytes compared to the 316L substrate. Wet wear tests revealed reduced friction coefficients in 0.9% NaCl relative to Hanks’ solution, highlighting the chemical interactions between the material surface and the electrolyte type and the significance of tribocorrosion in biocoatings.
Influence of the Deformation Degree on the Evolution of the Microstructure and Properties of Al-10.0Zn-2.7Mg-2.3Cu Alloy During Short-Flow Thermo-Mechanical Treatment
Authors: Li Hao , Zhao Yongxing , Huang Yuanchun , Liu Yu , Cheng Junhua
Published: January 2025

A simple short-flow thermo-mechanical treatment (TMT) named L-ITMT (consisting of three steps: solution, warm deformation, and solution) was applied to ultra-high-strength Al-10.0Zn-2.7Mg-2.3Cu alloy to study the influence of the deformation degree on the particle distribution, resolubility, microstructure evolution, recrystallization mechanism, formation and development of deformation bonds, and mechanical properties. Increasing the rolling deformation during the L-ITMT process can effectively break up the second phase at the grain boundary and promote its dissolution, which is beneficial to aging precipitation strengthening and improves the strength of the alloy. The dominant mechanism changes from recovery to recrystallization when the deformation degree reaches 80%. As the strain increases, the deformation band becomes flatter and eventually becomes nearly parallel to the RD direction, promoting the occurrence of geometric recrystallization or continuous recrystallization (CRX). Under high-strain conditions, the formation mechanisms of recrystallized grains include discontinuous recrystallization (DRX), CRX, and particle-stimulated nucleation (PSN), but the main contributions to the formation of large-area fine-grained bands are CRX and PSN. The results showed that as the deformation degree increased from 10% to 80%, the improvement of solid solubility and grain refinement in the short-flow TMT process increased the ultimate tensile strength (701 MPa), yield strength (658 MPa), and elongation (11.3%) of the alloy by 15.7%, 10.8%, and 842%, respectively. This shows that the short L-ITMT process has a synergistic effect in significantly improving the plasticity and maintaining the strength of this ultra-high strength Al-Zn-Mg-Cu alloy.
Surface Segregation Process and Its Influence on High-Temperature Corrosion of Iron-Based Alloys Containing Aluminium, Vanadium, Titanium and Germanium
Authors: Sobota Magdalena , Idczak Karolina , Konieczny Robert , Idczak Rafał
Published: January 2025

The surface segregation process and its influence on high-temperature corrosion of five alloys—Fe0.95Al0.05, Fe0.95V0.05, Fe0.90Al0.05V0.05, Fe0.95Ti0.05 and Fe0.95Ge0.05—were studied using X-ray photoelectron spectroscopy (XPS) and 57Fe Transmission Mössbauer Spectroscopy (TMS). To prepare the alloys with the highest surface concentration of solutes, the samples were annealed at elevated temperatures to induce the surface segregation process. After that, they were exposed to air at 870 K for 1 and 5 h. It was found that the Fe0.95Ti0.05 sample annealed at 1073 K had much better anti–corrosion properties than other alloys studied. This finding can be correlated with the extremely high concentration of titanium on the surface, which was more than four times that of iron. In contrast to other alloys studied in this work, the passive layer formed on the surface of Fe0.95Ti0.05 greatly enhanced its resistance to corrosion.
Advanced Platelet-Rich Fibrin (A-PRF) as Antibiotics Delivery System: In-Vitro Proof-of-Concept Study
Authors: Serafini Giorgio , Mariano Alessia , Lollobrigida Marco , Lamazza Luca , Mazzucchi Giulia , Spigaglia Patrizia , Barbanti Fabrizio , Scotto d’Abusco Anna , De Biase Alberto
Published: January 2025

Autologous blood centrifugation produces various forms of platelet concentrates widely used in tissue regenerative therapies due to their high concentrations of growth factors and abundance of autologous cells. Advanced Platelet-Rich Fibrin (A-PRF), introduced as a low-speed centrifugation product, contains an even higher concentration of growth factors, a greater number of cells, and a looser fibrin clot structure compared to previous Leukocyte and Platelet-Rich Fibrin (L-PRF). This study aims to assess the potential of A-PRF as a local delivery system for antibiotics. Different concentrations (0.5 mg/mL, 0.25 mg/mL, and 0.125 mg/mL) of injectable amoxicillin (AMX) and metronidazole (MTZ) were preliminarily tested for their impact on A-PRF clot formation, with 0.5 mg/mL selected for subsequent experiments. Blood samples from healthy volunteers were supplemented with antibiotics and centrifuged to form clots. Antibiotic-enriched A-PRF clots were immersed in phosphate-buffered saline (1x PBS) and analyzed at 24 h, 72 h, 7 days, and 14 days. AMX showed a consistent release (mean: 19.9 ± 4.8 ng/mL at 24 h) over 14 days, while MTZ demonstrated greater variability (mean: 12.8 ± 4.5 ng/mL at 24 h). AMX release remained constant over the 14-day period, with no significant variations among patients. In contrast, MTZ displayed a progressively lower release over time. Microbiological analysis revealed bacterial growth inhibition zones for Fusobacterium nucleatum (AMX: 23 mm, MTZ: 28 mm) and Prevotella intermedia (AMX: 34 mm, MTZ: 30 mm) at 24 h. These findings suggest that A-PRF can act as an effective local antibiotic delivery system, maintaining sustained antimicrobial activity and potentially reducing the need for systemic antibiotics.
Comparative Analysis of Thermal Comfort and Antimicrobial Properties of Base Fabrics for Smart Socks as Personal Protective Equipment (PPE)
Authors: Momotaz Farhana , Eike Rachel , Li Rui , Song Guowen
Published: January 2025

This study investigates the unique interplay between thermal comfort and antimicrobial properties in base fabrics, shaping the foundation for the development of “Smart Socks” as advanced personal protective equipment (PPE). By delving into the inherent qualities of fibers such as cotton, polyester, bamboo, and wool and exploring fabric structures like single jersey, terry, rib, and mesh, the research captures the dynamic relationship between material composition and performance. Terry fabrics emerge as insulators, wrapping the user in warmth ideal for cold climates, while mesh structures breathe effortlessly, enhancing air circulation and moisture wicking for hot environments. Cotton mesh, with its natural affinity for moisture, showcases exceptional moisture management. Antimicrobial testing, focused on fabrics’ interactions with Staphylococcus aureus, highlights the dormant potential of bamboo’s bio-agents while revealing the necessity for advanced antimicrobial treatments. This study unveils a vision for combining innovative fabric structures and fibers to craft smart socks that balance thermal comfort, hygiene, and functionality. Future directions emphasize sensor integration for real-time physiological monitoring, opening pathways to revolutionary wearable PPE.
Experimental-Based Simulation of EV Drive Mechanism
Authors: Jinadasa Lakith , Yadav Perla , Wray Alex , Ebrahimi Kambiz
Published: January 2025

A robust experimental-based vehicle drive system model and parameters tuned to match the real-world performance of the electro-mechanical systems is presented. The model is based on battery electric vehicle systems, focusing on the individual components of the drive system. The model includes motors, a battery pack, a driveline, and a DC-DC converter. Based on the collected empirical data using an on-board data acquisition system, and fine-tuning the critical vehicle parameters to align the simulation with the empirical data, stationary and drive cycle tests were designed and performed to replicate standard day-to-day driving conditions. Performance metrics such as the power consumption, the state of charge and the range were employed for the model validation. The validated model was then used for the performance study at different operating temperatures. The results of the study demonstrate that the model successfully mirrored the performance of the powertrain under various conditions and lined up with existing research work, providing a valuable tool for further research and development in battery electric vehicle technology.
Multiscale 1D-CNN for Damage Severity Classification and Localization Based on Lamb Wave in Laminated Composites
Authors: Munyaneza Olivier , Sohn Jung Woo
Published: January 2025

Lamb-wave-based structural health monitoring is widely employed to detect and localize damage in composite plates; however, interpreting Lamb wave signals remains challenging due to their dispersive characteristics. Although convolutional neural networks (CNNs) demonstrate a significant capability for pattern recognition within these signals relative to other machine learning models, CNNs frequently encounter difficulties in capturing all the underlying patterns when the damage severity varies. To address this issue, we propose a multiscale, one-dimensional convolutional neural network (MS-1D-CNN) to assess the damage severity and localize damage in laminated plates. The MS-1D-CNN is capable of learning both low- and high-level features, enabling it to distinguish between minor and severe damage. The dataset was obtained experimentally via a sparse array of four lead zirconate titanates, with signals from twelve paths fused and downsampled before being input into the model. The efficiency of the model was evaluated using accuracy, precision, recall, and F1-score metrics for severity identification, along with the mean squared error, mean absolute error, and R2 for damage localization. The experimental results indicated that the proposed MS-1D-CNN outperformed support vector machine and artificial neural network models, achieving higher accuracy in both identifying damage severity and localizing damage with minimal error.
Fitting Penalized Estimator for Sparse Covariance Matrix with Left-Censored Data by the EM Algorithm
Authors: Lin Shanyi , Zheng Qian-Zhen , Shang Laixu , Xu Ping-Feng , Tang Man-Lai
Published: January 2025

Estimating the sparse covariance matrix can effectively identify important features and patterns, and traditional estimation methods require complete data vectors on all subjects. When data are left-censored due to detection limits, common strategies such as excluding censored individuals or replacing censored values with suitable constants may result in large biases. In this paper, we propose two penalized log-likelihood estimators, incorporating the L1 penalty and SCAD penalty, for estimating the sparse covariance matrix of a multivariate normal distribution in the presence of left-censored data. However, the fitting of these penalized estimators poses challenges due to the observed log-likelihood involving high-dimensional integration over the censored variables. To address this issue, we treat censored data as a special case of incomplete data and employ the Expectation Maximization algorithm combined with the coordinate descent algorithm to efficiently fit the two penalized estimators. Through simulation studies, we demonstrate that both penalized estimators achieve greater estimation accuracy compared to methods that replace censored values with constants. Moreover, the SCAD penalized estimator generally outperforms the L1 penalized estimator. Our method is used to analyze the proteomic datasets.
On the High Elastic Modulus Mechanism of Iron Matrix Composites
Authors: Liu Hangrui , Zhang Qi , Fang Xing , Yang Xiaoyu , Wang Mai , Tang Xiqing , Wu Yanxin , Mi Zhenli
Published: January 2025

High modulus steels are characterized by high specific strength and specific stiffness, which can be attributed to the presence of hard reinforced particles. This paper investigates two common iron matrix composites, namely Fe/TiB2 and Fe/TiC, prepared through in situ reaction, focusing on their structures and properties. The results show that both types of reinforced particles in the high modulus steels consist of coarse primary particles and fine eutectic particles. In comparison to Fe/TiC composites, Fe/TiB2 composites exhibit larger elastic modulus (210 GPa). The reasons for the phenomenon that the experimentally measured values of the modulus of elasticity are lower than the calculated values at equilibrium are discussed. It was found that microporous defects left over from the casting process are often present inside the coarse primary particles, which can be the source of microcracks or fractures. In addition, matrix/particle interface stability calculations revealed that TiB2 possesses a distinctive hexagonal structure, resulting in a smaller interfacial distance (d0 = 1.375 Å) with the ferrite matrix phase. The high interfacial work of adhesion (Wad = 3.992 J/m2) further confirms the stronger interfacial stability of the Fe/TiB2 composite in comparison to the Fe/TiC composite.
Micro-Assembly Error Control of Specialized MEMS Friction Sensor
Authors: Zhou Wei , Wang Xiong , Xue Liwei , Guo Huihui , Qin Xiang
Published: January 2025

A skin friction sensor is a three-dimensional MEMS sensor specially designed for measuring the skin friction of hypersonic vehicle models. The accuracy of skin friction measurement under hypersonic laminar flow conditions is closely related to the fabrication and micro-assembly accuracy of MEMS skin friction sensors. In order to achieve accurate skin friction measurement, high-precision linear laser scanning ranging, multi-axis precision drive, and 3D reconstruction algorithms are investigated; a MEMS skin friction sensor micro-assembly height error measurement system is developed; and the MEMS skin friction sensor micro-assembly height error control method is carried out. The results show that the micro-assembly height error measurement of MEMS skin friction sensors achieves an accuracy of up to 2 μm. The height errors of the MEMS skin friction sensor were controlled within −8 μm to +10 μm after error control. The angular errors were controlled within the range of 0.05–0.25°, significantly improving micro-assembly accuracy in the height direction of the MEMS skin friction sensor. The results of hypersonic wind tunnel tests indicate that the deviation in the accuracy of the MEMS skin friction sensors after applying height error control is about 5%, and the deviation from the theoretical value is 8.51%, which indicates that height error control lays the foundation for improving the accuracy of skin friction measurement under hypersonic conditions.
Reconfigurable ScAlN Piezoelectric Micromachined Ultrasonic Transducer Arrays for Range Finding
Authors: Shang Wenling , Wang Danrui , Miao Bin , Yao Shutao , Ta Guifeng , Liu Haojie , Tao Jinyan , Liu Xiaonan , Zhao Xiangyong , Li Jiadong
Published: January 2025

Due to their compact sizes, low power consumption levels, and convenient integration capabilities, piezoelectric micromachined ultrasonic transducers (PMUTs) have gained significant attention for enabling environmental sensing functionalities. However, the frequency inconsistency of the PMUT arrays often leads to directional errors with the ultrasonic beams. Herein, we propose a reconfigurable PMUT array based on a Sc0.2Al0.8N piezoelectric thin film for in-air ranging. Each element of the reconfigurable PMUT array possesses the ability to be independently replaced, enabling matching of the required frequency characteristics, which enhances the reusability of the device. The experimental results show that the frequency uniformity of the 2 × 2 PMUT array reaches 0.38% and the half-power beam width (θ−3dB) of the array measured at 20 cm is 60°. At a resonance of 69.7 kHz, the sound pressure output reaches 7.4 Pa (sound pressure level of 108.2 dB) at 19 mm, with a reception sensitivity of approximately 11.6 mV/Pa. Ultimately, the maximum sensing distance of the array is 7.9 m, and it extends to 14.1 m with a horn, with a signal-to-noise ratio (SNR) of 19.5 dB. This research significantly expands the ranging capability of PMUTs and showcases their great potential in environmental perception applications.
Green Extraction of Carotenoids from Pumpkin By-Products Using Natural Hydrophobic Deep Eutectic Solvents: Preliminary Insights
Authors: Sportiello Lucia , Marchesi Emanuele , Tolve Roberta , Favati Fabio
Published: January 2025

Natural hydrophobic deep eutectic solvents (NaHDESs), composed of natural components like menthol, fatty acids, and organic acids, are sustainable alternatives to conventional solvents for extracting carotenoids from agro-industrial by-products. This study assessed the performance of nine NaHDESs for extracting β-carotene from pumpkin peels, identifying DL-menthol/lactic acid (1:2) as the most effective solvent, achieving a yield of 0.823 ± 0.019 mg/mL of β-carotene, corresponding to 93.95% of the yield obtained using acetone. Optimization through Box–Behnken design (BBD) and response surface methodology (RSM) established ideal extraction conditions: a molar ratio of HBA:HBD at 1:4, a solvent-to-sample ratio of 26:1, and an extraction time of 30 min. These conditions maximized β-carotene recovery while minimizing energy consumption and process costs. Using NaHDESs facilitates the valorization of food waste, achieving extraction efficiencies of up to 25.05% of the theoretical carotenoid content in pumpkin peels. Their high performance and environmentally friendly profile underscore the potential of NaHDESs as sustainable alternatives to conventional solvents.
The Effect of the NbVOx Synthesis Protocol on the Extractive Catalytic Oxidative Desulfurization of Dibenzothiophene
Authors: Stawicka Katarzyna , Gajewska Julia , Ziolek Maria , Trejda Maciej
Published: January 2025

NbVOx mixed oxides were synthesized, characterized, and evaluated as catalysts for the extractive catalytic oxidative desulfurization (ECODS) of dibenzothiophene (DBT) using acetonitrile as a solvent. The mixed oxides were prepared using two different vanadium precursors: ammonium metavanadate and vanadium(IV)-oxy acetylacetonate. These precursors influenced the acidic/basic properties and the concentration of oxygen vacancies in the resulting catalysts. The texture and surface properties of the synthesized materials were analyzed using nitrogen adsorption/desorption, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and UV–visible spectroscopy (UV-vis). Their catalytic activity was evaluated through the dehydration and dehydrogenation of 2-propanol and the ECODS of DBT. The mixed oxides synthesized with an excess of ammonium metavanadate (Nb:V = 1:2) demonstrated superior catalytic activity in removing DBT from the oil phase, achieving approximately 90% removal within 90 min at 60 °C. This enhanced activity is attributed to its higher acidity, greater concentration of oxygen vacancies, and the presence of vanadium peroxo ligands on its surface.
The Role of the Functionalization of Biomedical Fabrics on Their Ability to Adsorb and Release Drugs
Authors: Melone Lucio
Published: January 2025

Biomedical cotton gauzes (C0), after a first functionalization with glycidyl methacrylate (GMA) by a Fenton’s reaction (material C1), can be further modified in order to make them suitable for the adsorption and next release of drugs. Indeed, either after opening the epoxide ring through the addition of water (material C2) or after the introduction of amino groups through reaction with diamines (1,2-diaminoethane (material C3), 1,6-diaminohexane (material C4) and 1,12-diaminododecane (material C5)), the new gauzes can be uploaded with drugs. Both ibuprofen (IB), a non-steroidal anti-inflammatory, and amoxicillin (AM), a wide-spectrum β-lactam antibiotic, are efficiently adsorbed from their aqueous solutions at 20 °C onto C2–C5 (up to ≈0.8 mmol g−1 for IB and up to 0.4 mmol g−1 for AM) but not onto C0 and C1. The release of both IB and AM is affected by the ionic strength of the medium in which the release takes place. Indeed, kinetic experiments conducted with a physiological solution (NaCl (aq, 0.9% w/v) showed good release efficiencies while only modest or negligible release was observed if deionised water was the release medium. Moreover, the kind of functionalization plays an important role during both the adsorption and the release. The gauzes C3–C5 can be uploaded with a higher amount of drug relative to C2. Conversely, the drug is released quickly and in a higher amount from C2 relative to the gauzes containing the amino groups.
Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease
Authors: Abualassal Qais , Abudayeh Zead , Sirhan Ala’ , Mkia Abdulrahman
Published: January 2025

Quinazoline, a privileged scaffold in medicinal chemistry, offers promising potential in the synthesis of anti-Alzheimer’s disease (AD) drugs. This heterocyclic compound, characterized by its fused benzene and pyrimidine rings, enables the design of multifunctional agents targeting AD pathology. The drug-like aspects and pharmaceutical features of quinazoline derivatives have the potential to give rise to various therapeutic drugs. AD is a progressive neurodegenerative condition marked by memory decline, cognitive deterioration, and language disorders. Given its complexity and multifaceted nature, there is a pressing need to discover multi-target drugs to effectively address this debilitating disorder. A comprehensive literature review has demonstrated that quinazoline derivatives exhibit a wide range of therapeutic potential for AD. These compounds function as inhibitors of cholinesterases, β-amyloid aggregation, oxidative stress, and tau protein, among other protective effects. Here, we highlight the most significant and recent research on quinazoline-based anti-AD agents, aiming to support the development and discovery of novel treatments for AD.
Chloride and Acetonitrile Ruthenium(IV) Complexes: Crystal Architecture, Chemical Characterization, Antibiofilm Activity, and Bioavailability in Biological Systems
Authors: Jabłońska-Wawrzycka Agnieszka , Rogala Patrycja , Czerwonka Grzegorz , Hodorowicz Maciej , Kalinowska-Tłuścik Justyna , Karpiel Marta
Published: January 2025

Due to the emergence of drug resistance, many antimicrobial medications are becoming less effective, complicating the treatment of infections. Therefore, it is crucial to develop new active agents. This article aims to explore the ruthenium(IV) complexes with the following formulas: (Hdma)2(HL)2[RuIVCl6]·2Cl·2H2O (1), where Hdma is protonated dimethylamine and L is 2-hydroxymethylbenzimidazole, and [RuIVCl4(AN)2]·H2O (2), where AN is acetonitrile. This paper delves into the physicochemical characteristics and crystal structures of these complexes, employing various techniques such as spectroscopy (IR, UV–Vis), electrochemistry (CV, DPV), and X-ray crystallography. Hirshfeld surface analysis was also performed to visualize intermolecular interactions. Furthermore, the potential antibiofilm activity of the complexes against Pseudomonas aeruginosa PAO1 was investigated and the effect of the compounds on the production of pyoverdine, one of the virulence factors of the Pseudomonas strain, was assessed. The results show that particularly complex 1 reduces biofilm formation and pyoverdine production. Additionally, the bioavailability of these complexes in biological systems (by fluorescence quenching of human serum albumin (HSA) and molecular docking studies) is discussed, assessing how their chemical properties influence their interactions with biological molecules and their potential therapeutic applications.
Synthesis and Application of 4′-C-[(N-alkyl)aminoethyl]thymidine Analogs for Optimizing Oligonucleotide Properties
Authors: Fujiki Kota , Kakisawa Yuri , Mahmoud Elsayed M. , Ueno Yoshihito
Published: January 2025

Gapmer-type antisense oligonucleotides (ASOs) are an emerging class of therapeutic agents that directly inhibit pathogenic mRNA. In this study, three new 4′-C-substituted thymidine analogs were generated using a synthetic strategy recently established by our group, namely, 4′-C-(N-ethyl) aminoethyl (4′-EAE-T), 4′-C-(N-butyl) aminoethyl (4′-BAE-T), and 4′-C-(N-octyl) aminoethyl (4′-OAE-T). Their properties were evaluated and compared with those of previously reported analogs, including 4′-C-aminoethyl (4′-AE-T) and 4′-C-(N-methyl) aminoethyl (4′-MAE-T). The novel nucleoside analogs were subsequently incorporated into gapmer-type ASOs featuring phosphorothioate (PS) linkages and locked nucleic acids (LNAs) in the wing regions. The incorporation of 4′-EAE-T and 4′-BAE-T analogs resulted in RNA binding affinities similar to that of the previously reported 4′-MAE-T analog, whereas a marked decrease in RNA affinity was noted for 4′-OAE-T, however, this reduction was mitigated when combined with other chemical modifications. Furthermore, the structural modifications conferred enhanced nuclease resistance under bovine serum conditions, with 4′-EAE-T resulting in the highest stability, followed by 4′-BAE-T and 4′-OAE-T. Additionally, oligonucleotides modified with the developed analogs preserved their RNase H cleavage susceptibility, albeit inducing minor alterations in the cleavage pattern. Finally, the oligonucleotides were applied in a gene silencing experiment targeting the KRAS gene, conducted without the use of transfection agents, displaying gene silencing activities comparable to that of the control, with the exception of the 4′-OAE-modified nucleotide, which exhibited low activity.
Nanomaterials for Zinc Batteries—Aerogels
Authors: Ruan Hulong , Li Zeyuan , Jia Qixing , Wang Junjun , Chen Lina
Published: January 2025

Aqueous zinc batteries, mainly including Zn-ion batteries (ZIBs) and Zn–air batteries (ZABs), are promising energy storage systems, but challenges exist at their current stage. For instance, the zinc anode in aqueous electrolyte is impacted by anodic dendrites, hydrogen and oxygen precipitation, and some other harmful side reactions, which severely affect the battery’s lifespan. As for traditional cathode materials in ZIBs, low electrical conductivity, slow Zn2+ ion migration, and easy collapse of the crystal structure during ion embedding and migration bring challenges. Also, the slower critical oxygen reduction reaction (ORR), for example, in ZABs shows unsatisfactory results. All these issues greatly hindered the development of zinc batteries. Aerogel materials, characterized by their high specific surface area, unique open-pore structure formed by nanoporous structures, and excellent physicochemical properties, have a positive role in cathode modification, electrode protection, and catalytic reactions in zinc batteries. This manuscript provides a systematic review of aerogel materials, highlighting advancements in their preparation and application for zinc batteries, aiming to promote the future progress and development of aerogel nanomaterials and zinc batteries.
TiO2-Nanobelt-Enhanced, Phosphorescent, Organic Light-Emitting Diodes
Authors: Lenka Sushanta , Gupta Shivam , Rehman Bushra , Dubey Deepak Kumar , Wang Hsuan-Min , Sharma Ankit , Jayakumar Jayachandran , Wang Ching-Wu , Tai Nyan-Hwa , Grigalevicius Saulius , Jou Jwo-Huei
Published: January 2025

This study investigates the enhancement of organic light-emitting diode (OLED) performance through the integration of titanium dioxide (TiO2) nanocomposites within a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT/PSS) matrix. The nanocomposite films were prepared using a controlled dispersion of TiO2 belts into the PEDOT/PSS solution, followed by their incorporation into the OLED hole-injection layer (HIL). Our results demonstrate a significant improvement in device efficiency, attributed to the optimized charge carrier mobility and reduced recombination losses, which were achieved by the presence of TiO2. The nanocomposite hybrid layer enhances light emission efficiency due to its role in modifying surface roughness, promoting better film uniformity, and improving hole injection. The incorporation of TiO2 nanobelts into PEDOT/PSS led to significant efficiency enhancements, yielding a 39% increase in PEmax, a 37% improvement in CEmax, and a remarkable 72% rise in EQEmax compared to the undoped counterpart. This research provides insight into the potential of TiO2 nanocomposites in advancing OLED technology for next-generation display and lighting applications.
Soybean Flour Fortified with Gryllus assimilis Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo
Authors: Barnabé Michele Lílian da Fonseca , Vicente Laura Célia de Oliveira Souza , Martins Karina Vitoria Cipriana , Lacerda Gabrieli Fernandes , Rodrigues Elias , Oliveira Lívya Alves , Dias Kelly Aparecida , Pereira Stephanie Michelin Santana , José Vinicius Parzanini Brilhante de São , Dias Manoela Maciel dos Santos , Calhelha Ricardo C. , Leite Luciano Bernardes , Ribeiro Lúcia , Carvalho Izabela Maria Montezano de , Silva Bárbara Pereira da , Martino Hércia Stampini Duarte , Gonçalves Reggiani Vilela , Mattos Della Lucia Ceres
Published: January 2025

Background: Insects like Gryllus assimilis have an excellent nutritional profile, including iron. However, the bioavailability of this iron and its effects on intestinal health and oxidative balance remain unclear. To enhance acceptance, insects can be used in powder form and combined with common flours. Objective: This study evaluates the effects of Gryllus assimilis powder, alone or with soy flour, on iron bioavailability, intestinal health, and oxidative balance in rodents. Methods: Using the hemoglobin depletion/repletion method, 32 male Wistar rats were divided into four groups: A (standard diet + ferrous sulfate), B (diet + Gryllus assimilis + soy flour), C (diet + Gryllus assimilis), and D (diet + soy flour). Hemoglobin levels, regeneration efficiency, biological value, serum markers, intestinal health, and oxidative balance were assessed. Results: Food intake, weight gain, and bioavailability measures showed no differences. However, the Gryllus + soy group showed higher weekly and final hemoglobin levels than Gryllus alone. This combination also improved acetic acid levels, fecal moisture, and oxidative balance, increasing superoxide dismutase activity while reducing peroxidation products compared to Gryllus alone. Conclusion: These findings highlight the potential benefits of combining Gryllus assimilis with soy flour for iron bioavailability and overall health.
The Influence of Dietary Supplements on Exercise-Induced Gut Damage and Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis
Authors: Aitkenhead Robyn , Waldron Mark , Conway Gillian E. , Horner Katy , Heffernan Shane M.
Published: January 2025

Endurance exercise, especially under heat stress, temporarily compromises the integrity of the intestinal barrier in healthy individuals. Consequently, there is growing interest in developing effective dietary strategies to alleviate exercise-induced gastrointestinal symptoms and gut damage. This meta-analysis investigated the effects of dietary supplements on mitigating these challenges. The search was performed in November 2024 following PRISMA guidelines, and 26 peer-reviewed studies were included across three meta-analyses: (1) gastrointestinal symptoms, (2) circulating intestinal fatty acid-binding protein (i-FABP), and (3) exercise performance. The moderating effect of variables was assessed via sub-group analysis and meta-regression. Overall, there was no pooled effect of supplement interventions on gastrointestinal symptoms (Hedges’ g = 0.42, 95% CI −0.17: 1.02, p = 0.15), and probiotics had a moderate significant effect for gastrointestinal symptoms (Hedges’ g = −0.62, 95% CI −1.01; 1.01, p = 0.05). There was a significant increase in i-FABP concentrations pre- to post exercise (∆ 106%; Hedges’ g = 1.01, 95% CI 0.63; 1.38, p = 0.01). There were no pooled or sub-group differences for exercise performance for any supplements (p = 0.53). Moderate-to-large heterogeneity was observed across studies (I2 ≥ 58.6%), and candidate moderators (exercise duration, modality, and environmental temperature) had no significant effect on any outcomes (p > 0.05). A significant increase in circulating i-FABP during exercise was observed. However, when examining the effects of different supplement categories, although significance was observed for a select few supplements, the changes in i-FABP, gastrointestinal symptoms, and exercise performance were outside of clinical relevance. Although probiotics showed a moderate significant effect for gastrointestinal symptoms, the conflicting findings across studies may have been due to inadequate control of confounding variables across studies. Further research is required to assess the alternative dietary supplements’ effects on gastrointestinal health and exercise performance, particularly under varied environmental conditions, where more rigorous control for cofounding factors is implemented.
The Impact of Dietary Fiber on Cardiovascular Diseases: A Scoping Review
Authors: Zhang Lu , Chen Yifei , Yang Qiaoren , Guo Jun , Zhou Siyu , Zhong Tian , Xiao Ying , Yu Xi , Feng Ke , Peng Ye , Han Zhong , Feng Feifei , Wang Ling
Published: January 2025

Background/Objectives: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality globally, placing an ever-increasing burden on healthcare systems. Dietary factors play a crucial role in the development and progression of CVD. Among them, dietary fiber has emerged as a potential modifiable factor with the potential to impact CVD risk. However, the specific and independent effects of dietary fiber on CVD are still not fully understood, making this area of research both challenging and of great significance. Methods: The publications of human studies involving the impact of dietary fiber on CVD were retrieved from databases including PubMed, Embase, Web of Science, Scopus, Cochrane Library, CBM, and China National Knowledge Infrastructure (CNKI). A search was conducted within these databases for studies published between 2014 and 20 March 2024. The included literature was screened and summarized. Results: A total of seven articles were included, and the related studies encompassed various types of dietary fiber, including soluble and insoluble dietary fiber, as well as research from different countries and regions. The outcome indicators involved an important measure known as the hazard ratio (HR). Conclusions: Increasing the intake of dietary fiber could reduce the risk of cardiovascular diseases through various mechanisms. To increase the consumption of dietary fiber from multiple sources, it would be beneficial to develop and promote healthcare interventions to enhance people’s awareness of the health benefits of dietary fiber, promote the consumption of fiber-rich foods, and advocate for a healthier diet.
Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis
Authors: Montemor Cláudia Nascimento , Fernandes Marcos Tadeu Parron , Marquez Audrey Souza , Bignardi Paulo Roberto , Poli Regina Célia , Gâmbaro Gustavo Aliano , da Silva Rubens Alexandre da , Ngomo Suzy , Fernandes Karen Barros Parron
Published: January 2025

Background: Vitamin D is beneficial for musculoskeletal health. Although low levels of vitamin D are linked to increased pain in knee osteoarthritis (OA), their association with functionality remains understudied. Objective: This study aimed to investigate the association between vitamin D deficiency and functional status in elderly individuals with OA and explore the potential correlation between vitamin D deficiency and plasma levels of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). Methods: The study included older adults (≥60 years) from an ageing study, encompassing 105 OA patients and 152 controls. OA diagnosis was confirmed radiographically, and the WOMAC questionnaire assessed functional impairment in these patients. Blood samples were collected to measure 25(OH) vitamin D levels by chemiluminescence and TNF-α and IL-6 levels by ELISA. Results: Patients with vitamin D insufficiency/deficiency exhibited more severe cases of OA compared to those with normal vitamin D levels (p = 0.04). Vitamin D levels were inversely correlated with functional impairment in OA, according to the WOMAC Index (global: rS = −0.25, p = 0.01; pain: rS = −0.21, p = 0.03). Moreover, OA patients with vitamin D deficiency showed significantly higher levels of TNF-α and IL-6 (p < 0.05, Mann−Whitney test). Conclusions: Reduced levels of vitamin D are associated with more severe cases of hip and knee osteoarthritis, increased pain, greater functional impairment, and elevated serum levels of TNF-α and IL-6. Further research is required to elucidate the mechanisms underlying the influence of vitamin D on osteoarthritis and to evaluate the potential benefits of vitamin D supplementation for mitigating disease symptoms and progression.
The Application and Mechanism Analysis of Enteral Nutrition in Clinical Management of Chronic Diseases
Authors: Li Qingye , Wang Jing
Published: January 2025

Chronic diseases have emerged as a significant challenge in global public health due to their complex etiologies, prolonged disease courses, and high treatment costs. With the aging population and changes in lifestyle, the number of patients with chronic diseases has increased dramatically, which has brought heavy burden to families and society. Chronic diseases are often accompanied by digestive and absorptive disorders as well as metabolic disorders, resulting in insufficient nutrient intake, further worsening the condition and weakening the physique. Therefore, the importance of nutritional intervention in chronic disease management has become increasingly prominent. As an important means of nutritional intervention, enteral nutrition plays a key role in improving the nutritional status of patients, promoting rehabilitation, shortening hospital stay and so on, thereby providing a new solution for chronic disease management. This article reviews the current application status, mechanism of action and comprehensive benefit of enteral nutrition in the clinical management of chronic diseases. Through systematic review and analysis of existing research findings, the specific application effects and mechanisms of enteral nutrition in chronic disease management are clarified. This review aims to promote the popularization and application of enteral nutrition, in order to effectively improve patients’ treatment outcomes and quality of life, provide scientific evidence for the optimization of clinical management strategies for chronic diseases, and offer theoretical support for the development of enteral nutrition products, and thereby drive the continuous improvement of chronic disease management.
Effects of Vegetable and Fruit Juicing on Gut and Oral Microbiome Composition
Authors: Sardaro Maria Luisa Savo , Grote Veronika , Baik Jennifer , Atallah Marco , Amato Katherine Ryan , Ring Melinda
Published: January 2025

Background: In recent years, juicing has often been promoted as a convenient way to increase fruit and vegetable intake, with juice-only diets marketed for digestive cleansing and overall health improvement. However, juicing removes most insoluble fiber, which may diminish the health benefits of whole fruits and vegetables. Lower fiber intake can alter the microbiota, affecting metabolism, immunity, and mental health, though little is known about juicing’s specific effects on the microbiota. This study addresses this gap by exploring how juicing impacts gut and oral microbiome composition in an intervention study. Methods: Fourteen participants followed one of three diets—exclusive juice, juice plus food, or plant-based food—for three days. Microbiota samples (stool, saliva, and inner cheek swabs) were collected at baseline, after a pre-intervention elimination diet, immediately after juice intervention, and 14 days after intervention. Moreover, 16S rRNA gene amplicon sequencing was used to analyze microbiota taxonomic composition. Results: The saliva microbiome differed significantly in response to the elimination diet (unweighted UniFrac: F = 1.72, R = 0.06, p < 0.005; weighted UniFrac: F = 7.62, R = 0.23, p-value = 0.0025) with a significant reduction in Firmicutes (p = 0.004) and a significant increase in Proteobacteria (p = 0.005). The juice intervention diets were also associated with changes in the saliva and cheek microbiota, particularly in the relative abundances of pro-inflammatory bacterial families, potentially due to the high sugar and low fiber intake of the juice-related products. Although no significant shifts in overall gut microbiota composition were observed, with either the elimination diet or the juice intervention diets, bacterial taxa associated with gut permeability, inflammation, and cognitive decline increased in relative abundance. Conclusions: These findings suggest that short-term juice consumption may negatively affect the microbiota.