bluuebunny/crossref_metadata_2025 huggingface dataset:
Early-Onset Parkinson’s Disease: Creating the Right Environment for a Genetic Disorder
Authors: Kolicheski Ana , Turcano Pierpaolo , Tamvaka Nicole , McLean Pamela J. , Springer Wolfdieter , Savica Rodolfo , Ross Owen A.
Published: December 2022

Parkinson’s disease (PD) by its common understanding is a late-onset sporadic movement disorder. However, there is a need to recognize not only the fact that PD pathogenesis expands beyond (or perhaps to) the brain but also that many early-onset patients develop motor signs before the age of 50 years. Indeed, studies have shown that it is likely the protein aggregation observed in the brains of patients with PD precedes the motor symptoms by perhaps a decade. Studies on early-onset forms of PD have shown it to be a heterogeneous disease with multiple genetic and environmental factors determining risk of different forms of disease. Genetic and neuropathological evidence suggests that there are α-synuclein centric forms (e.g., SNCA genomic triplication), and forms that are driven by a breakdown in mitochondrial function and specifically in the process of mitophagy and clearance of damaged mitochondria (e.g., PARKIN and PINK1 recessive loss-of-function mutations). Aligning genetic forms with recognized environmental influences will help better define patients, aid prognosis, and hopefully lead to more accurately targeted clinical trial design. Work is now needed to understand the cross-talk between these two pathomechanisms and determine a sense of independence, it is noted that autopsies studies for both have shown the presence or absence of α-synuclein aggregation. The integration of genetic and environmental data is critical to understand the etiology of early-onset forms of PD and determine how the different pathomechanisms crosstalk.
Problems in the Formation of Language Environment in Learning Arabic
Authors: Negoro Panji Puspo , Jamaluddin Wan , Amiruddin Amiruddin
Published: December 2022

This article aims to discuse about the Arabic-speaking education at the Islamic boarding school Al Ghifariy of East Lampung. Many students use Javanese and do not use proper grammar. This study aims to find out how to solve the implementation of an environmental program in Arabic and the problems there, as well as the supporting and inhibiting factors in the implementation of language activities. By using The descriptive analysis method, sample of data collected by interview, observation and documentation. The results of the data analysis show that the students lack the desire to learn Arabic, due to the lack of support from those closest to them, an environment that does not support progress in educational attainment and students lack self-confidence. Attempts to solve it the school is trying to improve the skills of teachers by involving them in educational trainings from the government.
Tathwîr Wihdah Dirâsiyyah fî ‘Ilm an-Nahwi li Thalabah bi al-Ma’had As-Salafiy
Authors: Walidah Zazinatul , Koderi Koderi , Sagala Rumadani , Masayu Sovia , Erlina Erlina
Published: December 2022

This study aims to develop and the effectiveness of the learning module qowaid an-nahwiyah, with an research and development research approach of the eight-stage Borg and gall development model, namely potential and problems, data collection, product design, design validation, design revision, product testing, product revision,use trial. Validators are material, media and learning experts. Data analysis by t-test. The results of the study 1) the process of developing the module 2) the quality of the developed module is very feasible with the percentage of material 96% in the very good category then media 95% very good category, then learning of 96% category is good, the results of the responses from the students stated that they were very interesting. The effectiveness of the product can be seen from the increase in learning outcomes reaching 14.35. It was concluded that the al-qowaid al-nahwiyah module developed by the researcher was effective, feasible for learning nahwu.
Qiyâm al-‘Ijtimâ’iyyah fî Syi’r Abî al-‘Atâhiyyah
Authors: Latif Abdul , Rodhy Harisca  , Muzhillah Ar Alqurbani
Published: December 2022

Abu al-‘Atahiyah was famous for his ascetical poetry, but the researcher found that in Abu al-‘Atahiyah’s anthology, not all of his poems go with the ascetical theme’s only. Rather, there are also life values, such as social values ​​that establish other human foundations that spread bonds of mercy, love, tolerance, kindness, cooperation, observance of conscience, fear of God and other meanings. The parameters of the human formulation of society are defined in the Islamic conception. The theory used in this research is the theory of life values ​​by Noeng Muhadjir. The approach used in this research is the pragmatic approach. This approach prove that a literature work is a tool to achieve the aims of the creator of literature works, in addition to pleasure or entertainment also for the sake of enlightenment and education. This research found there are sixteen social values, and these social values show that Abu al-‘Atahiyah, who is known as a religious poet, is also a poet who pays attention to social life.
LANDSCAPE AND SPATIAL FACTORS OF INFLUENCE ON THE MEDIA FORMATION OF ARCHITECTURE AND CITY SPACES OF LVIV
Authors: Parneta Mariana
Published: December 2022

Media formation as an informative essence of architecture and urban spaces is formed under the influence of a number of factors. Throughout history, the landscape has always been a determining factor in creation of an architectural environment, therefore landscape and spatial factors are primary ones for the media formation of architecture and spaces. The media formation of the landscape directly relates to its ability to influence on human consciousness. The identification and systematization of landscape and spatial factors allow us to set up criterias for their influence on the media formation of architecture and urban spaces. In order to find out the role of landscape and spatial factors on the media formation of urban spaces, their analysis was carried out on the example of Lviv city. The assessment of the interrelationships of the landscape and spatial factors of Lviv's environment with its media formation was carried out on the basis of a multidimensional matrix of interrelationships, which made it possible to determine the main informative identifiers of the city's spaces. It was determined that the natural components of Lviv landscape (relief, water network, greenery) establish the natural and aesthetic potential of the urban environment, and the characteristics of anthropogenic elements (planning and functional city structure, silhouette of the city) strengthen them. The complex action of natural and anthropogenic landscape and spatial factors creates the physical and mental media formation of the city that consists in the uniqueness of Lviv's character and ensures its recognizability.
RELEVANCE AND TRENDS IN THE FORMATION OF SCIENTIFIC AND EDUCATIONAL CENTERS
Authors: Sheremetieva Viktoriia
Published: December 2022

The article argues for the need to create scientific and educational centers and analyzes the features of the organization of scientific and educational spaces. As a result of the study, the main trends in the formation of scientific and educational centers were identified. The main idea of the terms "lifelong learning", "adult education", "permanent education" is the development of personality and adaptation of a person to new life, social and professional experience. Such training plays an important role in the areas of employment and social security, economic well-being and competitiveness. Now there are no comprehensive scientific and educational institutions that would meet the requirements of modern society and provide a comfortable microclimate for all age groups. Therefore, the issue of organizing scientific and educational centers is extremely important and relevant for the intellectual, cultural, social and economic development of society. The SECs are focused on educating the general public and are designed to instill in their listeners a love for science and popularize it. On the basis of the studied theoretical studies, the following trends in the formation of modern scientific and educational centers have been identified: polyfunctionality; integration of the educational and business functions into production and research spaces; the characteristic architectural image of the NPC is created with the help of a symbiosis of educational and research concepts; when designing an SEC based on institutions, it is necessary to take into account the potential of existing architectural objects for scientific purposes to adapt, innovate and integrate the educational function; ergonomics, safety, comfortable conditions for all age groups of the population. An analysis of the world experience in designing scientific and educational institutions made it possible to identify the following trends: SECs must comply with the modern concept of the educational process; free planning, spatial frame structure, adaptive spaces are characteristic; in most classrooms it is advisable to use the "case method"; subordination to the context of the surrounding development and integration into the existing landscape; characteristic is the ability to transform spatial and architectural-figurative structures; combining in one block of related disciplines that complement each other; "dynamic" adaptation of scientific and educational spaces in order to optimize and supplement or change the functional purpose. The main functional groups of SECs have been identified. The Scientific and Educational Center is a kind of partnership that integrates all types of education, the capabilities of universities, scientific organizations, industrial base and business to accelerate technological development, master advanced industry technologies, provide a basis for gaining practical experience in creating intellectual results and mastering style of scientific activity, formation of ideas about future professional activity.
RECONSTRUCTION TECHNIQUES DURING THE CONSTRUCTION OF TYPICAL RESIDENTIAL BUILDINGS IN UKRAINE
Authors: Novosad Iryna
Published: December 2022

The article highlights the analysis of the development of Ukrainian cities and it will have to be said that the advantage in the development have residential buildings of industrial origin. The main disadvantages of typical residential series are: high heat consumption, chaotic compositional solutions of facades, this is primarily due to individual solutions of glazing balconies and loggias of residents, lack of free space for people with disabilities. The factors influencing the reconstruction of typical residential buildings are analyzed. Examples of reconstruction of typical residential buildings in European countries prove that reconstruction is an effective economic method of restoring and improving the architectural properties of the existing housing stock. The article gives examples of damaged load-bearing structures of typical residential buildings. The author proposes an integrated approach to reconstruction and provides the basic techniques used for the reconstruction of typical residential buildings. The main principle of reconstruction should be aimed at restoration and improvement of volumetric-spatial solutions of typical residential buildings in the system of Ukrainian cities. Techniques are a reconstruction tool that allow to increase and improve: planning solutions of the apartment and entrance group of the house, to change the facade and volumetric solutions of residential development. The reconstruction of the house should be considered in the complex of street and district development and approved by the leading specialists-architects at the city planning councils.
Analysis of the completeness of the russian market of over-the-counter medicines for the treatment of neurotic disorders
Authors: Oleynikova T. A. , Barybina E. S.
Published: December 2022

Mental health is an integral part and the most important component of human health. However, today half of the population of our country has signs of its violation, of which about 5% need professional psychiatric care. Mental disorders lead to a significant decrease in the quality of life, disability of the population, as well as prolonged and recurrent disability. In recent years, the COVID-19 pandemic has caused significant negative consequences for mental health. According to research data in 2020 every third resident of Russia complained of symptoms of depression. Fear, anxiety, depression associated with the introduction of restrictive measures and self-isolation have led to the emergence of chronic stress in the population, which is one of the harbingers of the development of mental disorders. In 2022, the deterioration of mental health is noted against the background of the current political situation in the world. Frequent manifestations of stress lead to various psychoemotional disorders (anxiety, increased irritability, neurosis, sleep disorders, etc.). To avoid these consequences, drugs of various pharmacological groups (sedatives, nootropic, adaptogens, antidepressants and others) are used in the complex therapy of anxiety disorders. Within the framework of the concept of responsible self-treatment, the therapy of these disorders is carried out with over-the-counter medications.
Gender and Feminism in Pre-colonial and Postcolonial Nigerian Literature: Reading, Achebe, Adichie, and Atta
Authors: Chowdhury-Mohammad Shadman
Published: December 2022

For more than a century since British colonization of Nigeria (1914-1960), the voices of Nigerian women have largely been silent, both in Nigerian literature and in society. Chinua Achebe’s Things Fall Apart (1958), which is widely regarded as one of the literary works that ushered in modern Nigerian writing, provides evidence of the existence and types of patriarchal structures in pre-colonial contact Nigeria that silenced women. Achebe’s novel has influenced an entire generation of late twentieth century and twenty-first century Nigerian authors whose writings engage with female silence/silencing, and with Nigerian women’s resistance to that silencing, in the postcolonial period. This silence/silencing is a consequence of anti-woman norms embedded in both local Nigerian customs and traditions and in beliefs and practices held over from colonial times. 

In this paper, two of these contemporary Nigerian works—Chimamanda Ngozi Adichie’s Purple Hibiscus (2003) and Sefi Atta’s Everything Good Will Come (2005) are compared with Things Fall Apart. Adichie’s and Atta’s novels are both set in the latter part of the twentieth century; and, when analyzed in tandem with Achebe’s, they offer an exploration of the ways in Chowdhury-Mohammad 4 which the combination of Nigerian customs and the remnants of British colonial influence impact on Nigerian women’s ability to make themselves heard. 

For the analysis of the novels, this paper draws on writings of notable postcolonial and feminist theorists such as Frantz Fanon and Simone de Beauvoir, as well as the writings of “Third World” theorists such as Gayatri Spivak to contextualize the discussion of female silence/silencing.
A Cosmic Odyssey: The Lovecraftian Construction of the Epic
Authors: Barrie Waleed
Published: December 2022

It could perhaps be theorized that a culture’s roots lie in its tales of Gods, heroes, and Monsters. Certainly the foundations behind many of the world’s civilizations are intertwined with such stories. Creation myths give way to accounts we deem fantastical in nature, sagas that portray divine wars fought by opposing pantheons, or journeys by humans inspired to do so in their name. It is through mortals that the structure of these narratives become truly epic, the word itself reigning as the Epic.
Production and Quantification of Virulence Factors in Malassezia Species
Authors: Hadrich Inès , Khemekhem Nahed , Neji Sourour , Trablesi Houaida , Ilahi Amin , Sellami Hayet , Makni Fattouma , Ayadi Ali
Published: December 2022

Seventy-seven strains of Malassezia were included in this study. Biofilm and hydrolytic enzyme production were studied by using specific solid media. The Real-Time reverse transcriptase qPCR method was applied to determine the overexpression of genes encoding the extracellular enzymes. All included Malassezia species produced biofilms. No statistically significant difference was observed between Malassezia species in biofilm formation (p = 0.567). All Malassezia species produced lipase, and 95% of Malassezia globosa showed a strong enzymatic activity (Pz = 0.55 ± 0.02). A statistically significant difference was observed between the mean keratinase indices of Malassezia slooffiae and the other Malassezia species (p = 0.005). The overexpression of one or more genes was observed in 100% of strains isolated from patients with folliculitis, 87.5% – with pityriasis versicolor, and 57.14% of the control group isolates. A statistically significant difference in the lipase gene expression (p = 0.042) was between the strains from patients with folliculitis and the control group. This investigation provides more information about the frequency of the production of the major enzymes considered virulence factors of Malassezia species. Interestingly, the overexpression of one or more genes was observed in strains isolated from patients with Malassezia disorders.
Penerapan Media Pembelajaran Audio Visual Terhadap Peningkatan Hasil Belajar Peserta Didik Pada Mata Pelajaran PAI Kelas VII 6 Di SMP Negeri 7 Makassar
Authors: Nengsih Ratika , Novianti R.S Ifut , Hakim Ahmad
Published: December 2022

The purpose of this study was to find out how the Application of Pendengaran Penglihatan Learning Alat Improve Student Learning Outcomes in PAI Subjects Class VII 6 at SMP Negeri 7 Makassar and to determine student learning outcomes using Pendengaran Penglihatan Learning Alat in PAI learning class VII 6 in SMP Negeri 7 Makassar. This research is a Classroom Action Research (CAR) which consists of two cycles, where each cycle consists of two meetings. The sample in this study was class VII 6 students at SMP Negeri 7 Makassar with a total of 28 students. The techniques used in collecting data in this study were observation, interviews, tests, and documentation. The test consists of two types, namely pre-test and post-test, the pre-test is carried out at the beginning of the meeting before the students are given treatment or the learning process by applying Audio Visual learning media while the post-test is carried out at the end of each meeting in each cycle. The data analysis technique used in this study is to use the formula for calculating the percentage and average value (Mean) for both student activity sheet data analysis and student learning outcomes. The results of this study are the application of Audio Visual learning media in PAI subjects is able to increase the sense of responsibility individually and in groups and the application of this Audio Visual learning model can improve student learning outcomes in PAI subjects. Thus the increase in student learning outcomes can be proven by the value of students who have increased and are getting better. The average value in the pre-test is 69.28 with a percentage of 42%, the average post-test value in the first cycle is 76.96 with a percentage of 71.42% and the post-test average value in the second cycle is 91, 42 with a percentage of 92.85%. The data proves that student learning outcomes can increase and have met the class success indicator, namely 80% with the application of Audio Visual learning media.
Aplikasi Sistem Pakar Diagnosis Penyakit HIV/AIDS Menggunakan Metode Forward Chaining Berbasis Web
Authors: Handoko Agustin Yoga , Baswardono Wiyoga , Pratama Falah Insan
Published: December 2022

Sering kali seseorang mengalami gejala penyakit yang di anggap biasa saja seperti demam hingga menggigial, muntah, nyeri pada sendi, nyeri pada otot, sakit kepada, dan masih banyak lagi gejala tersebut merupakan ciri-ciri dari gejala penyakit HIV, dan untuk mengetahui penyakit yang diderita dibutuhkan seorang dokter spesialis penyakit dalam di bidang kesehatan, seorang pasien perlu mendatangi rumah sakit atau klinik spesialis dalam dengan serangkaian prosedur untuk bisa berkonsultasi dengan dokter, sehingga hal tersebut menyita banyak waktu pasien, dan mahalnya biaya untuk berkonsultasi dengan dokter spesialis dalam. Mengatasi masalah tersebut membutuhkan pengetahuan pasien tentang gejala dan jenis penyakit sejak dini. Sehingga dibuatlah sebuah sistem pakar untuk diagnosis penyakit HIV/AIDS yang dapat digunakan sebagai sarana untuk penyuluhan sejak dini mengetahui penyakit yang sedang menimpa masyarakat. Metode inferensi forward chaining dengan metodologi pengembangan Rational Unified Proccess (RUP) dengan tahapan Inception, Elaboration, Construction, dan Transition. Dengan hasil yaitu Sistem Pakar Diagnosis Penyakit HIV/AIDS Menggunakan Metode Forward Chaining Berbasis Web untuk memudahkan masyarakat dan dokter spesialis agar mengetahui deteksi dini penyakit HIV/AIDS melalui gejala-gejala yang di alami.
Rancang Bangun Sistem Informasi Penentu Calon Penerima Beasiswa pada Fakultas Ekonomi Universitas Garut
Authors: Setiawan Ridwan , Latifah Ayu , Dwi Lestari Wulan
Published: December 2022

Universitas Garut merupakan salah satu perguruan tinggi swasta di Garut yang berdiri pada tahun 1998. Fakultas Ekonomi (Fekon) merupakan salah sau fakultas yang ada di Universitas Garut dalam proses pembagian beasiswa di fekon ini masih dilakukan secara manual dengan mengirimkan berkas kebagian kemahasiswaan secara langsung dan berulang. Tujuan penelitian ini adalah untuk merancang penentu calon penerima beasiswa yang mana dapat membantu dalam proses pembagian beasiswa secara cepat, tepat dan akurat. Metodologi yang digunakan dalam rekayasa perangkat lunak yaitu metodologi Rational Unified Process (RUP) dengan tahapan yang digunakan inception, elaboration, dan construction, dengan pemodelan yang digunakan Unified Modelling Languange (UML) dengan use case diagram, activity diagram, sequence diagram dan class diagram. Pada metodologi Rational Unified Process tahapan dibatasi sampai construction, sedangkan fase transition tidak dilaksanakan. Hasil dari penelitian ini yaitu rancang bangun sistem informasi penentu calon penerima beasiswa berbasis web.
Rancang Bangun Sistem Informasi Pengaduan Layanan Menggunakan Metode Rational Unified Process
Authors: Mulyani Asri , Septiana Yosep , Alamsyah Renaldy
Published: December 2022

Sekolah Dasar Islam Terpadu (SDIT) Bina Insan Qur’ani merupakan lembaga pendidikan sekolah dasar yang terakreditasi A terletak di Jl. Raya Cibatu Bandrek, RT 02 RW 06, Desa Padasuka, Kecamatan Cibatu, Kabupaten Garut, Jawa Barat, 44185. Dalam mengembangkan dan meningkatkan kualitas pengaduan layanan sekolah dengan cepat serta kepuasan layanan senantiasa terpenuhi, setiap sekolah tentunya akan menyiapkan layanan yang terbaik bagi setiap siswa yaitu dengan memanfaatkan teknologi informasi yang ada pada saat ini. Diakrenakan belum tersedianya sistem pengaduan yang berada di SDIT Bina Insan Qurani sehingga dapat menyulitkan orang tua siswa dalam memberikan aspirasi atau saran kepada pihak sekolah. Tujuan dari adanya penelitian ini untuk membuat sebuah sistem yang mampu melaporkan hasil pengaduan layanan Sekolah Dasar Islam Terpadu (SDIT) Bina Insan Quráni. Penelitian ini menggunakan metode Rational Unified Process (RUP) dengan melewati empat fase yaitu inception, elaboration, contruction dan transition, perancangan pemodelan yang digunakan yaitu pemodelan Unified Modeling Language (RUP). Dalam pembuatan website nya menggunakan bahasa pemrograman PHP, dengan framework Laravel dan MySQL sebagai database server nya. Hasil dari penelitian ini yaitu sistem informasi pengaduan layanan yang yang dapat diakses pada berbagai browser, dengan fitur yang di dalamnya dapat membantu pihak pengelola sekolah dalam menerima pengaduan atau usulan dari orang tua siswa.
Evaluasi Pembelajaran Online pada Masa Pandemic Covid -19 di Perguruan Tinggi di Kota Pekalongan
Authors: Susanto Susanto , Achwandi Ribut
Published: December 2022

One of the impacts of the Covid-19 pandemic in Indonesian education is the implementation of online learning which seems to be forced because in terms of infrastructure and human resources it is not sufficient. The purpose of this research is to find and map the advantages and disadvantages of online learning so that in the end it can be a recommendation for improvement and enhancement of online learning. This research is a quantitative descriptive study with data sources from the results of questionnaires to students at higher education institutions in Pekalongan. The questionnaire is in the form of closed and open questions.

The results of this study indicate that the average score of online learning evaluations gets a score of 89 (70%) which belongs to the high criteria. This means that the implementation of online learning in higher education institutions is good from the learning planning stage to the assessment stage. From the six elements of the online learning process that are measured, namely the learning contract, learning objectives and learning outcomes, assessment, lecture material, student involvement and student learning resources respectively get a score of 68%, 69%, 71%, 68%, 72%, and 71%.

However, students still provide criticism and suggestions for improvements to lecturers, learning, online infrastructure and financing. From the results of this study, online learning during the pandemic period was still effective to be taught while still fixing several aspects that were recommended for improvement, namely from academic policies, development of lecturer resources, and increasing the capacity of system infrastructure.
Pengembangan Modul Berbasis Pendekatan Science, Environment, Technology and Society (SETS) pada Materi Sistem Pernapasan dan Sistem Pencernaan
Authors: Pitung Anastasia , Setiawan Dwi Candra
Published: December 2022

The module is the smallest unit of teaching and learning programs that students learn individually or or learners to themselves.This study aims to develop a module based on the science, environment, technology and society (SETS) approach to the material of the respiratory system and digestive system in humans that is suitable for use in learning biology. This development research method refers to the 4D model which has four stages, namely: 1) define ( definition ), 2) design (planning or design), 3) development (development ), 4) disseminate (deployment). The stages used in the development of this module are limited to only 3 stages, namely define, design and development. The results of the validation of the first material expert, the percentage was 86%, the second percentage was greater than the first, which was 96%, with very valid criteria. And for the results of the first validation, the media expert got a percentage of 89 %, the second by media experts was greater than the first validation of 94% with very feasible criteria, so it can be concluded that the development of modules based on the science, environment, technology and society (SETS) approach to the material The validity level of the respiratory system and digestive system in humans is seen to be very feasible and can be used in learning.
Pengembangan Lembar Kerja Siswa (LKS) Berbasis Model Pembelajaran Think Pair Share (TPS) dengan Media Mind Map pada Materi Sistem Pencernaan Makanan Kelas VIII SMP Negeri 5 Kodi
Authors: Bani Yohana , Widyaningrum Diyah Ayu
Published: December 2022

Teaching materials are important to support the learning process. One type of teaching material is worksheets. The development of LKS with the Think Pair share learning model was carried out because it was carried out to meet the needs of students regarding interesting, fun, and innovative teaching materials. The purpose of this study was to determine the results of developing LKS Based on the TPS Learning Model with Mind Map media on Food Digestive System Material for Class VIII SMP Negeri 5 Kodi which met the valid criteria. The research method used in this study is a research and development method with a 4D model. The research procedure consists of the define (defining), design (design), develop (development) stages. The types of data used in this research are qualitative and quantitative data. Based on the results of the study, the validation of the mind map-based TPS learning model by material experts was 83.3% so that it met the criteria of good/decent and media experts was 98.8% so that it met the criteria of very good/very feasible.
Pengembangan Multimedia Interaktif Berbasis Articulate Storyline Sebagai Media Pembelajaran Siswa Kelas X SMA
Authors: Wijayanti Wijayanti , Prayitno Trio Ageng
Published: December 2022

One of the obstacles found in biological learning is the unavailability of interesting and up-to-date technology based learning media for learning activities. The students only learn the material by presented through Powerpoint and package books provided by a particular publishing team. Therefore, the purpose of this research was conducted that aims to produce a learning media on the form of interactive multimedia based on Articulate Storyline in material virus. The type of this research is R&D (research and development), by use the ADD development which is adapted model from the ADDIE development. The research instruments used were interview transcripts and experts validation questionnaire. The result of this research is Articulate Storyline based interactive multimedia which is feasible and interesting to use. It can be seen from the percentage results of the validation by the media expert is 94% and material expert is 95%. Accordance with the results of this research above, it can be concluded that Articulate Storyline based interactive multimedia is very useful for the students learning on class X high school as a more interactively and independently learning media.
Pengembangan Modul IPA Berbasis Project Based Learning (PjBL)
Authors: Sarti Bonafansiani Maria , A. Bangun Wilyanti
Published: December 2022

The purpose of this research is to produce teaching materials for Ecosystem Modules based on Project Based Learning models that are suitable for students to use. The type of research used is Research and Development (R & D) by following three stages adapted from the ADDIE development model compiled by Dick and Carry which consists of Analysis (analysis), design (design), development (development), Implementation (implementation)) and Evaluation (evaluation). However, researchers did not use the fourth and fifth stages because they took a very long time. The results of validation by several experts, namely material experts, media experts show that the Project Based Learning model-based module is valid and feasible to use. The conclusion of this research is the Project Based Learning model-based module is valid and feasible to be used as a learning resource which is expected to have an impact on student learning activities.
Pengaruh Metode Mengajar Guru, Fasilitas Belajar, Lingkungan Belajar di Sekolah dan Motivasi Terhadap Hasil Belajar IPS Siswa Kelas VII SMP Negeri 5 Kodi Balagahar
Authors: Ote Dominggus Ana , Purwati Titik
Published: December 2022

In the classroom, the level of intelligence and student activity varies, therefore the teacher must be able to treat students according to their level of intelligence and be able to make all students active in learning. The research carried out is a type of qualitative research. The sample used in this study was class VII SMP Negeri 5 Kodi Balaghar, totaling 67 students. Researchers used several questionnaire techniques, observation techniques, and documentation techniques. The data analysis technique used is descriptive statistics and statistical analysis. The results showed (1) the teaching method did not have a significant effect on the learning outcomes of class VII students of SMP Negeri 5 Kodi Balagahar. It is proven by the result of Sig.count of 0.930 > 0.05. (2) Learning facilities have a significant influence on the learning outcomes of class VII students. It is proven by the result of Sig.count of 0.001 < 0.05. (3) The learning environment does not have a significant effect on the learning outcomes of class VII students. It is proven by the result of Sig.count of 0.677 > 0.05. (4) Motivation has a significant influence on the learning outcomes of class VII students. It is proven by the result of Sig.count of 0.023 <0.05. (5) Teachers' teaching methods, learning facilities, learning environment in schools and motivation simultaneously affect the Social Studies learning outcomes of Class VII students of SMP Negeri 5 Kodi Balagahar. It is proved with the sig.count result of 0.008 < 0.05. This means that simultaneously the teacher's teaching methods, learning facilities, learning environment in schools and motivation affect the Social Studies learning outcomes of Class VII students of SMP Negeri 5 Kodi Balagahar.
Mass mortality of collector urchins Tripneustes gratilla in Hawai`i
Authors: Work TM , Dagenais J , Rameyer B , Breeden R , Weatherby TM
Published: December 2022

As grazers, sea urchins are keystone species in tropical marine ecosystems, and their loss can have important ecological ramifications. Die-offs of urchins are frequently described, but their causes are often unclear, in part because systematic examinations of animal tissues at gross and microscopic level are not done. In some areas, urchins are being employed to control invasive marine algae. Here, we describe the pathology of a mortality event in Tripneustes gratilla in Hawai`i where urchins were translocated to control invasive algae. Although we did not determine the cause of the mortality event, our investigation indicates that animals died from inflammation of the test and epidermal ulceration, followed by inability to maintain coelomic fluid volume, colonization of coelomic fluid by opportunists (diatom, algae), and inappetence. Parasites, bacteria, fungi, and viruses were not evident as a primary cause of death. Pathology was suggestive of a toxin or other environmental cause such as lack of food, possibilities that could be pursued in future investigations. These findings highlight the need for caution and additional tools to better assess health when translocating marine invertebrates to ensure maximal biosecurity.
Using stable isotope chronologies within squid gladii (Doryteuthis gahi) to evaluate dietary differences by fishing region and season
Authors: Jones JB , Bustamante P , Guillou G , Arkhipkin AI
Published: December 2022

Stable isotopes are a useful tool for understanding diet and migration in squid, which often play an important role in marine food webs. The Patagonian long-finned squid fishery around Falkland Islands waters is managed separately for each of its biannual fishing seasons and 2 sub-areas of the fishing zone. However, factors driving differences in the timing of recruitment and squid size between sub-areas have never been resolved. To investigate whether seasonal and spatial variation in life history parameters of the Patagonian long-finned squidDoryteuthis gahiis driven by differences in diet, stable isotope profiles (δ13C and δ15N) were measured along the gladius—the internal chitinous shell—to reconstruct a chronological record of habitat and feeding variations and to compare fishing seasons and sub-areas using a mixed modelling approach. Here we show that isotopic niche was distinct between the fishing seasons, but negligible differences in isotopic niche were found between sub-areas of the fishing zone. This suggests that spatial differences in life history parameters are not a result of dietary variation. Substantial variation in δ13C and δ15N values along the gladius indicated versatility in feeding behaviours and dietary habits over time. Squid in the second fishing season occupied a lower trophic level (mean = 3.2) than the first season (mean = 3.5). Patterns in δ13C values indicated more complex and substantial migration patterns in the second fishing season. This coincides with the current knowledge of this species’ spawning migrations. We anticipate that these data may be used for future studies investigating the role of squid within the Patagonian Shelf marine ecosystem. Analysis of the squid gladius has applications for other loliginid squid species in future studies.
FARKLI DENTAL ANKSİYETE DÜZEYLERİNE SAHİP HASTALARIN DİŞ HEKİMİ ÜNİFORMA TERCİHLERİNİN DEĞERLENDİRİLMESİ–KESİTSEL BİR ÇALIŞMA
Authors: KÜDEN Cihan , YAZAN Helin , YÜKSEK Ahmet , ÖĞÜÇBİLEK İpek , KORKMAZ Ökkaş , AVCILI Hasan
Published: December 2022

Bu çalışma diş muayenesi veya tedavisi için başvuran çeşitli dental anksiyetesi olan yetişkin hastaların farklı üniforma giyen diş hekimlerine yönelik tercihleri karşılaştırılmıştır. Onamları alınmış olan hastalara 8 adet sosyodemografik bilgi, 5 adet modifiye dental anksiteyete ölçeği (MDAS) ve 2 adet hekim üniformasının değerlendirilmesi ile ilgili sorularıdan oluşan veri toplama formu uygulandı. Hastalar düşük-orta anksiyete düzeyi (DOA) ve yüksek-aşırı yüksek anksiyete düzeyi (YYA) olmak üzere 2 gruba ayrıldı. Demografik özellikler için tanımlayıcı istatistiksel analizler yapıldı ve Pearson Ki-kare testi kullanıldı (p = 0.05). Tüm katılımcıların ortalama MDAS değeri 12.92’dir. DOA gösteren hastalar 299 kişi olup tüm katılımcıların %59.8’ini oluştururken YYA gösteren hastalar 201 kişi olup katılımcıların %40.2’sini oluşturdu. Hastaların üniforma seçimi farklı anksiyete düzeylerinden etkilenmiştir (p= 0.048). DOA için üniforma seçiminde en yüksek %31.1 ile siyah, YYA için %26.9 ile renkli üniforma olmuştur. YYA’ya sahip hastalar için hekim üniforması rengi önemli bir faktör olarak bulunmuştur. Farklı anksiyete düzeyine sahip hastaların tercih ettikleri üniformanın temel nedeninin diş hekiminin görünüşünün güven verme duygusu yaratmasıyla ilgili olduğu sonucuna varıldı.
Delignification of Cassava Peel by Using Alkaline Hydrogen Peroxide Method: Study of Peroxide Concentration, Solid/Liquid Ratio, and pH
Authors: Afifah Dini Nur , Damajanti Neni , Mustholidah Maulani , Hariyanti
Published: December 2022

Cassava peel is a natural material with cellulose content reaching 33.33%. In order to utilize cassava peel as a biodegradable polymer and renewable energy alternative, a delignification process is essential to separate cellulose from hemicellulose and lignin, which prevents the penetration of cellulose hydrolyzer. The delignification method chosen in this study was alkaline hydrogen peroxide (AHP). The AHP is based on the autoxidation of lignin using hydrogen peroxide (H2O2) in an alkaline environment. This method was chosen because it can damage the lignocellulosic structure with relatively low energy and is more selective for lignin. However, under certain conditions, AHP can trigger carbohydrate depolymerization, which decreases yield. Therefore, it is necessary to study the effect of H2O2 concentration, Solid/Liquid ratio (S/L) (w/v), and pH to evaluate the effectiveness of lignin removal in cassava peel. The concentration of H2O2 was varied into 1.5%, 3%, 4.5%, 6%, and 7.5%. The S/L ratio is varied to 1:3, 1:5, 1:7, 1:9,1:12. The pH of the solution was varied to 8, 9, 10, 11, and 12. The reaction temperature was maintained at 70-90 °C for 3 hours. The results showed that lignin could be reduced to 84.05% for 3 hours by using  6% H2O2, an S/L ratio of 1:5, and a pH of 11. The reaction carried out under these conditions can also increase the amount of cellulose from 33.33% to 49.00%.
Thermal Energy Conversion in Making Biochar from Jengkok Tobacco Waste Using Pyrolysis Extrusion Model
Authors: Iskandar Taufik , Fitri Ayu Chandra Kartika
Published: December 2022

The pyrolysis process has many models with different characteristics and specifications. Each model provides a different conversion value depending on the temperature value, length of time, and the number of raw materials used. Jengkok Tobacco waste was dangerous because it contains Arsenic (As), and was used as a biochar product with economic and strategic value through the extrusion model pyrolysis process. The purpose of this study was to determine the thermal conversion value (yield percentage) of the pyrolysis process of tobacco waste material into biochar at the optimal temperature and processing time. The specified variables consist of process temperatures (400, 450, 500, 550, and 600°C) and processing times (30, 35, and 40 minutes). The product of the process will be analyzed statistically using the Spearman rank correlation test and followed by Minitab to produce the optimal value. The results showed that the thermal conversion value in making biochar was 29.476% (»30%) at a process temperature of 500°C and a processing time of 30 minutes.
Mapping Canada’s Green Economic Pathways for Battery Minerals: Balancing Prospectivity Modelling With Conservation and Biodiversity Values
Authors: Lawley Christopher J. M. , Mitchell Matthew G. E. , Stralberg Diana , Schuster Richard , McIntire Eliot , Bennett Joseph R.
Published: December 2022

Electrification of Canada’s energy and transport sectors is essential to achieve net-zero emissions by 2050 and will require a vast amount of raw materials. A large proportion of these critical raw materials are expected to be sourced from as yet undiscovered mineral deposits, which has the potential to accelerate environmental pressures on natural ecosystems. Herein we overlay new prospectivity model results for a major source of Canada’s battery minerals (i.e., magmatic Ni ± Cu ± Co ± PGE mineral systems) with five ecosystem services (i.e., freshwater resources, carbon, nature-based recreation, species at risk, climate-change refugia) and gaps in the current protected-area network to identify areas of high geological potential with lower ecological risk. New prospectivity models were trained on high-resolution geological and geophysical survey compilations using spatial cross-validation methods. The area under the curve for the receive operating characteristics (ROC) plot and the preferred gradient boosting machines model is 0.972, reducing the search space for more than 90% of deposits in the test set by 89%. Using the inflection point on the ROC plot as a threshold, we demonstrate that 16% of the most prospective model cells partially overlap with the current network of protected and other conserved areas, further reducing the search space for new critical mineral deposits. The vast majority of the remaining high prospectivity cells correspond to ecoregions with less than half of the protected areas required to meet national conservation targets. Poorly protected ecoregions with one or more of the five ecosystem services are interpreted as hotspots with the highest potential for conflicting land-use priorities in the future, including parts of southern Ontario and Québec, western Labrador, and northern Manitoba and Saskatchewan. Managing hotspots with multiple land-use priorities would necessarily involve partnerships with both Indigenous peoples whose traditional lands are affected, and other impacted communities. We suggest that prospectivity models and other machine learning methods can be used as part of natural resources management strategies to balance critical mineral development with conservation and biodiversity values.
A mechanistic model of cross-bridge migration in RBC aggregation and disaggregation
Authors: Maung Ye Swe Soe , Kim Sangho
Published: December 2022

Red blood cells (RBCs) clump together under low flow conditions in a process called RBC aggregation, which can alter RBC perfusion in a microvascular network. As elevated RBC aggregation is commonly associated with cardiovascular and inflammatory diseases, a better understanding of aggregation is essential. Unlike RBC aggregation in polymer solutions which can be well explained by polymer depletion theory, plasma-mediated RBC aggregation has features that best match explanations with cross-bridging mechanisms. Previous studies have demonstrated the dominant role of fibrinogen (Fg) in promoting aggregate formation and recent cell-force spectroscopy (CFS) experiments on interacting RBC doublets in plasma have reported an inverse relationship between disaggregation force and the adhesive contact area between RBCs. This has led investigators to revisit the hypothesis of inter-RBC cross-bridging which involves cross-bridge migration under interfacial tension during the forced disaggregation of RBC aggregates. In this study, we developed the cross-bridge migration model (CBMM) in plasma that mechanistically represents the migrating cross-bridge hypothesis. Transport of mobile Fg cross-bridges (mFg) was calculated using a convection-diffusion transport equation with our novel introduction of convective cross-bridge drift that arises due to intercellular friction. By parametrically transforming the diffusivity of mFg in the CBMM, we were able to match experimental observations of both RBC doublet formation kinematics and RBC doublet disaggregation forces under optical tweezers tension. We found that non-specific cross-bridging promotes spontaneous growth of adhesion area between RBC doublets whereas specific cross-bridging tends to prevent adhesion area growth. Our CBMM was also able to correlate Fg concentration shifts from healthy population blood plasma to SLE (lupus) condition blood plasma with the observed increase in doublet disaggregation forces for the RBC doublets in SLE plasma.
Effect of condylar chondrocyte exosomes on condylar cartilage osteogenesis in rats under tensile stress
Authors: Shi Yuan , Shao Jiaqi , Zhang Zanzan , Zhang Jianan , Lu Haiping
Published: December 2022

Background: Functional orthoses are commonly used to treat skeletal Class II malocclusion, but the specific mechanism through which they do this has been a challenging topic in orthodontics. In the present study, we aimed to explore the effect of tensile stress on the osteogenic differentiation of condylar chondrocytes from an exosomal perspective.

Methods: We cultured rat condylar chondrocytes under resting and tensile stress conditions and subsequently extracted cellular exosomes from them. We then screened miRNAs that were differentially expressed between the two exosome extracts by high-throughput sequencing and performed bioinformatics analysis and osteogenesis-related target gene prediction using the TargetScan and miRanda softwares. Exosomes cultured under resting and tensile stress conditions were co-cultured with condylar chondrocytes for 24 h to form the Control-Exo and Force-Exo exosome groups, respectively. Quantitative real time PCR(RT-qPCR) and western blotting were then used to determine the mRNA and protein expression levels of Runx2 and Sox9 in condylar chondrocytes.

Results: The mRNA and protein expression levels of Runx2 and Sox9 in the Force-Exo group were significantly higher than those in the Control-Exo group (p < 0.05). The differential miRNA expression results were consistent with our sequencing results. Bioinformatics analysis and target gene prediction results showed that the main biological processes and molecular functions involved in differential miRNA expression in exosomes under tensile stress were biological processes and protein binding, respectively. Kyoto Gene and Genome Data Bank (KEGG) pathway enrichment analysis showed significant enrichment of differentially expressed miRNAs in the mTOR signaling pathway. The differentially expressed miRNAs were found to target osteogenesis-related genes.

Conclusion: These results suggest that stimulation of rat condylar chondrocytes with tensile stress can alter the expression levels of certain miRNAs in their exosomes and promote their osteogenic differentiation. Exosomes under tensile stress culture conditions thus have potential applications in the treatment of Osteoarthritis (OA).