bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison by Life-Cycle Assessment of Alternative Processes for Carvone and Verbenone Production
Authors: Becerra Jaime-Andrés , González Juan-Miguel , Villa Aída-Luz
Published: August 2022

Verbenone and carvone are allylic monoterpenoid ketones with many applications in the fine chemicals industry that can be obtained, respectively, from the allylic oxidation of α-pinene and limonene over a silica-supported iron hexadecachlorinated phthalocyanine (FePcCl16-NH2-SiO2) catalyst and with t-butyl hydroperoxide (TBHP) as oxidant. As there are no reported analyses of the environmental impacts associated with catalytic transformation of terpenes into value-added products that include the steps associated with synthesis of the catalyst and several options of raw materials in the process, this contribution reports the evaluation of the environmental impacts in the conceptual process to produce verbenone and carvone considering two scenarios (SI-raw-oils and SII-purified-oils). The impact categories were evaluated using ReCiPe and IPCC methods implemented in SimaPro 9.3 software. The environmental impacts in the synthesis of the heterogeneous catalyst FePcCl16-NH2-SiO2 showed that the highest burdens in terms of environmental impact come from the use of fossil fuel energy sources and solvents, which primarily affect human health. The most significant environmental impacts associated with carvone and verbenone production are global warming and fine particulate matter formation, with fewer environmental impacts associated with the process that starts directly from turpentine and orange oils (SI-raw-oils) instead of the previously extracted α-pinene and limonene (SII-purified-oils). As TBHP was identified as a hotspot in the production process of verbenone and carvone, it is necessary to choose a more environmentally friendly and energy-efficient oxidizing agent for the oxidation of turpentine and orange oils.
Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat
Authors: Xu Yanan , Cai Weidong , Chen Rui , Zhang Xinjiang , Bai Zhixian , Zhang Yu , Qin Yuting , Gu Ming , Sun Yinggang , Wu Yanzhi , Wang Zeying
Published: August 2022

One of the critical elements in evaluating the quality of cashmere is its fineness, but we still know little about how it is regulated at the metabolic level. In this paper, we use UHPLC–MS/MS detection and analysis technology to compare the difference in metabolites between coarse cashmere (CT_LCG) and fine cashmere (FT_LCG) skin of Liaoning cashmere goats. According to the data, under positive mode four metabolites were significantly up-regulated and seven were significantly down-regulated. In negative mode, seven metabolites were significantly up-regulated and fourteen metabolites were significantly down-regulated. The two groups’ most significant metabolites, Gly–Phe and taurochenodeoxycholate, may be crucial in controlling cashmere’s growth, development, and fineness. In addition, we enriched six KEGG pathways, of which cholesterol metabolism, primary bile acid biosynthesis, and bile secretion were enriched in positive and negative modes. These findings offer a new research idea for further study into the critical elements influencing cashmere’s fineness.
The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Authors: Borozdenko Denis A. , Shmigol Tatiana A. , Ezdoglian Aiarpi A. , Gonchar Darya I. , Karpechenko Natalia. Y. , Lyakhmun Dmitri N. , Shagina Anastasia D. , Cherkashova Elvira A. , Namestnikova Daria D. , Gubskiy Ilya L. , Chernysheva Anastasia A. , Kiseleva Nina M. , Negrebetsky Vadim V. , Baukov Yuri I.
Published: August 2022

Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosages to study the cytokine profile using real-time PCR and cytometric bead array (CBA). Stroke in rats was simulated by the middle cerebral artery occlusion method (MCAO). Several tests were performed to characterize the neurological deficit and locomotor activity of the rats, and afterwards, postmortem, the number of astrocytes was counted using immunohistochemistry. Compound 4 in in vitro tests dose-dependently reduced the expression of interleukin-1β (IL1β), and inducible nitric oxide synthase (iNOS) genes in cell culture and increased the concentration of cytokines: interleukin-2, 4, 6 (IL-2, IL-4, and IL-6). In vivo Compound 4 increased the orienting-exploratory behavior, and reduced neurological and motor deficit. The number of astrocytes that promote and support inflammation was lower in the group treated with Compound 4. The stroke volume measured by magnetic resonance imaging (MRI) showed no difference. We have shown that Compound 4 demonstrates anti-inflammatory activity by increasing the synthesis of anti-inflammatory and reducing pro-inflammatory cytokines, and positively affects the neurological deficit in rats. Thus, Compound 4 has a high therapeutic potential in the management of patients after a stroke and requires further study of its neuroprotective properties.
Comparative Interaction Studies of Quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2,6-Methylated-β-cyclodextrin
Authors: Vakali Vasiliki , Papadourakis Michail , Georgiou Nikitas , Zoupanou Nikoletta , Diamantis Dimitrios A. , Javornik Uroš , Papakyriakopoulou Paraskevi , Plavec Janez , Valsami Georgia , Tzakos Andreas G. , Tzeli Demeter , Cournia Zoe , Mauromoustakos Thomas
Published: August 2022

Quercetin (QUE) is a well-known natural product that can exert beneficial properties on human health. However, due to its low solubility its bioavailability is limited. In the present study, we examine whether its formulation with two cyclodextrins (CDs) may enhance its pharmacological profile. Comparative interaction studies of quercetin with 2-hydroxyl-propyl-β-cyclodextrin (2HP-β-CD) and 2,6-methylated cyclodextrin (2,6Me-β-CD) were performed using NMR spectroscopy, DFT calculations, and in silico molecular dynamics (MD) simulations. Using T1 relaxation experiments and 2D DOSY it was illustrated that both cyclodextrin vehicles can host quercetin. Quantum mechanical calculations showed the formation of hydrogen bonds between QUE with 2HP-β-CD and 2,6Μe-β-CD. Six hydrogen bonds are formed ranging between 2 to 2.8 Å with 2HP-β-CD and four hydrogen bonds within 2.8 Å with 2,6Μe-β-CD. Calculations of absolute binding free energies show that quercetin binds favorably to both 2,6Me-β-CD and 2HP-β-CD. MM/GBSA results show equally favorable binding of quercetin in the two CDs. Fluorescence spectroscopy shows moderate binding of quercetin in 2HP-β-CD (520 M−1) and 2,6Me-β-CD (770 M−1). Thus, we propose that both formulations (2HP-β-CD:quercetin, 2,6Me-β-CD:quercetin) could be further explored and exploited as small molecule carriers in biological studies.
Dwarf Kiwi (Actinidia arguta Miq.), a Source of Antioxidants for a Healthy and Sustainable Diet
Authors: Garcia-Herrera Patricia , Maieves Helayne A. , Vega Erika N. , Perez-Rodriguez María Luisa , Fernandez-Ruiz Virginia , Iriondo-DeHond Amaia , Castillo Maria Dolores del , Sanchez-Mata Maria Cortes
Published: August 2022

The feasibility of using dwarf kiwi fruits (Actinia arguta Miq.) as a healthy and sustainable food, compared to other types of commercial kiwi fruits, was evaluated in the present study. The overall antioxidant capacity of these fruits was assessed by either extraction-dependent methods (ABTS, ORAC) or the direct method called Quick, Easy, New, CHEap, Reproducible (QUENCHER) (DPPH, FRAP, Folin–Ciocalteu), applied for the first time to analyze kiwi fruits. With this methodology, all the molecules with antioxidant capacity are measured together in a single step, even those with high molecular weight or poor solubility in aqueous extraction systems, such as antioxidant dietary fiber. The effect of kiwi extracts on physiological and induced intracellular reactive oxygen species (ROS) production on IEC-6 cells was also analyzed, as well as total phenolic content (TPC) by Fast Blue BB, flavonols, hydroxycinnamic acids, and hydroxybenzoic acids. A. arguta fruits showed the highest values in all the antioxidant assays, being remarkably higher than the other kiwi species for Q-FRAP and Q-DPPH. Dwarf kiwi showed the highest potential in reducing physiological ROS and the highest values of TPC (54.57 mgGAE/g), being hydroxybenzoic acids the main phenolic family found (2.40 mgGAE/g). Therefore, dwarf kiwi fruits are a natural source of antioxidants compared to conventional kiwi fruits, being a sustainable and healthy alternative to diversify fruits in the diet.
Chrysanthemum boreale Makino Inhibits Oxidative Stress-Induced Neuronal Damage in Human Neuroblastoma SH-SY5Y Cells by Suppressing MAPK-Regulated Apoptosis
Authors: Song Parkyong , Choi Seo Young , Hwang Ji Sun , Park Hyeon Cheal , Kim Keun Ki , Son Hong-Joo , Hong Chang-Oh , Kim Yu-Jin , Kim Wanil , Lee Kwang Min
Published: August 2022

Oxidative stress has been demonstrated to play a pivotal role in the pathological processes of many neurodegenerative diseases. In the present study, we demonstrated that Chrysanthemum boreale Makino extract (CBME) suppresses oxidative stress-induced neurotoxicity in human neuroblastoma SH-SY5Y cells and elucidated the underlying molecular mechanism. Our observations revealed that CBME effectively protected neuronal cells against H2O2-induced cell death by preventing caspase-3 activation, Bax upregulation, Bcl-2 downregulation, activation of three mitogen-activated protein kinases (MAPKs), cAMP response element-binding protein (CREB) and NF-κB phosphorylation, and iNOS induction. These results provide evidence that CBME has remarkable neuroprotective properties in SH-SY5Y cells against oxidative damage, suggesting that the complementary or even alternative role of CBME in preventing and treating neurodegenerative diseases is worth further studies.
In Vitro and Human Pilot Studies of Different Topical Formulations Containing Rosa Species for the Treatment of Psoriasis
Authors: Gavra Diana Ioana , Endres Laura , Pető Ágota , Józsa Liza , Fehér Pálma , Ujhelyi Zoltán , Pallag Annamária , Marian Eleonora , Vicas Laura Gratiela , Ghitea Timea Claudia , Muresan Mariana , Bácskay Ildikó , Jurca Tünde
Published: August 2022

The aim of this study was to evaluate the phytochemical profile and antioxidant properties of the extracts from three Rosa species (R. canina, R. damascena, R. cairo), to develop and investigate topical formulations with lyophilized forms of extracts for the treatment of psoriasis. Phytochemical screening and in vitro total antioxidant capacity (DPPH, FRAP, CUPRAC, SOD) of studied samples were examined and compared. Lyophilized extracts of roses were dissolved in Transcutol HP and different formulations of creams were prepared. Franz diffusion method was used to evaluate the drug release and biocompatibility was tested on HaCaT cells. Rosa damascene had the best results regarding all the analyses that were conducted. After the evaluation of topical products, the formulation with Rosa damascena extract in a self-emulsifying drug delivery system was tested on a human clinical study that involved 20 patients. At the end of the clinical study an improvement in the quality of life of the patients was observed and erythema, induration and scaling were reduced. The present study indicates that our examined extracts exhibited great phenolic content, antioxidant capacity and safety profile of topical formulation and therefore can be used as a reliable source of natural antioxidants and may be used as a complementary treatment to improve the quality life of patients with psoriasis or may be tested on another diseases.
Twelve New Seco-Pregnane Glycosides from Cynanchum taihangense
Authors: Wang Yu-Bo , Zhao Dan , Su Shan-Shan , Chen Gang , Wang Hai-Feng , Pei Yue-Hu
Published: August 2022

For our interest in the potential biologically active and structurally unique steroidal glycosides, continued phytochemical investigation of Cynanchum taihangense was carried out; twelve new seco-pregnane glycosides, cynataihosides I–L (1–4), M-T (7–14), and two known glycosides, glaucoside A (5) and atratcynoside F (6), were isolated from the 95% ethanol extract of Cynanchum taihangense. Two new aglycones were found among compounds 10, 11, 13, and 14. The structures of the glycosides were elucidated based on 1D and 2D NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence. The cytotoxicity of compounds against three human tumor cell lines (HL-60, THP-1, and PC-3) were evaluated by MTT assay. Compound 11 displayed significant cytotoxicity against THP-1 and PC-3 cell line with IC50 values of 5.08 and 22.75 μm, respectively. Compounds 3 and 14 exhibited moderate and selective cytotoxicity on HL-60 and THP-1 with IC50 values of 17.78 and 16.02 μm, respectively.
Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking
Authors: El-Kersh Dina M. , Abou El-Ezz Rania F. , Fouad Marwa , Farag Mohamed A.
Published: August 2022

Acylated flavonoids are widely distributed natural metabolites in medicinal plants and foods with several health attributes. A large diversity of chemical structures of acylated flavonoids with interesting biological effects was reported from several plant species. Of these, 123 compounds with potential antimicrobial, antiparasitic, anti-inflammatory, anti-nociceptive, analgesic, and anti-complementary effects were selected from several databases including SCI-Finder, Scopus, Google Scholar, Science Direct, PubMed, and others. Some selected reported biologically active flavonoids were docked in the active binding sites of some natural enzymes, namely acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, aldose reductase, and HIV integrase, in an attempt to underline the key interactions that might be responsible for their biological activities.
The Determination of Cannabinoids in Urine Samples Using Microextraction by Packed Sorbent and Gas Chromatography-Mass Spectrometry
Authors: Rosendo Luana M. , Rosado Tiago , Oliveira Patrik , Simão Ana Y. , Margalho Cláudia , Costa Suzel , Passarinha Luís A. , Barroso Mário , Gallardo Eugenia
Published: August 2022

Cannabis is the most consumed illicit drug worldwide, and its legal status is a source of concern. This study proposes a rapid procedure for the simultaneous quantification of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH), cannabidiol (CBD), and cannabinol (CBN) in urine samples. Microextraction by packed sorbent (MEPS) was used to pre-concentrate the analytes, which were detected by gas chromatography–mass spectrometry. The procedure was previously optimized, and the final conditions were: conditioning with 50 µL methanol and 50 µL of water, sample load with two draw–eject cycles, and washing with 310 µL of 0.1% formic acid in water with 5% isopropanol; the elution was made with 35 µL of 0.1% ammonium hydroxide in methanol. This fast extraction procedure allowed quantification in the ranges of 1–400 ng/mL for THC and CBD, 5–400 ng/mL for CBN and 11-OH-THC, and 10–400 ng/mL for THC-COOH with coefficients of determination higher than 0.99. The limits of quantification and detection were between 1 and 10 ng/mL using 0.25 mL of sample. The extraction efficiencies varied between 26 and 85%. This analytical method is the first allowing the for determination of cannabinoids in urine samples using MEPS, a fast, simple, and low-cost alternative to conventional techniques.
A Modular Approach to Atropisomeric Bisphosphines of Diversified Electronic Density on Phosphorus Atoms
Authors: Demchuk Oleg M. , Martyna Aleksandra , Kwaśnik Mateusz , Szwaczko Katarzyna , Strzelecka Dorota , Mirosław Barbara , Pietrusiewicz Kazimierz Michał , Urbanczyk-Lipkowska Zofia
Published: August 2022

The series of C2-symmetric biaryl core-based non-racemic bisphosphines possessing substituents of different electronic properties: both EDG and EWG were obtained in a short sequence of good yielding transformations, started from commercial 1,3-dimethyl-2-nitrobenzene. Several different approaches leading to the desirable ligands were practically evaluated. Notably, the synthesis of the entire series of ligands could be performed with the utilization of a single early-stage precursor DIDAB (6,6′-diiodo-2,2′,4,4′-tetramethylbiphenyl-3,3′-diamine), which could be easily obtained in enantiomerically pure form. The obtained compounds at concentrations of 50 and 200 µM showed various biological activity against normal human dermal fibroblast, ranging from inactivity through time-dependent action and ending up with high toxicity.
Autonomous-Strengthening Adhesive Provides Hydrolysis-Resistance and Enhanced Mechanical Properties in Wet Conditions
Authors: Ezazi Mohammadamin , Ye Qiang , Misra Anil , Tamerler Candan , Spencer Paulette
Published: August 2022

The low-viscosity adhesive that is used to bond composite restorative materials to the tooth is readily damaged by acids, enzymes, and oral fluids. Bacteria infiltrate the resulting gaps at the composite/tooth interface, demineralize the tooth, and further erode the adhesive. This paper presents the preparation and characterization of a low-crosslink-density hydrophilic adhesive that capitalizes on sol-gel reactions and free-radical polymerization to resist hydrolysis and provide enhanced mechanical properties in wet environments. Polymerization behavior, water sorption, and leachates were investigated. Dynamic mechanical analyses (DMA) were conducted using water-saturated adhesives to mimic load transfer in wet conditions. Data from all tests were analyzed using appropriate statistical tests (α = 0.05). The degree of conversion was comparable for experimental and control adhesives at 88.3 and 84.3%, respectively. HEMA leachate was significantly lower for the experimental (2.9 wt%) compared to control (7.2 wt%). After 3 days of aqueous aging, the storage and rubbery moduli and the glass transition temperature of the experimental adhesive (57.5MPa, 12.8MPa, and 38.7 °C, respectively) were significantly higher than control (7.4MPa, 4.3 MPa, and 25.9 °C, respectively). The results indicated that the autonomic sol-gel reaction continues in the wet environment, leading to intrinsic reinforcement of the polymer network, improved hydrolytic stability, and enhanced mechanical properties.
Holographic Encryption Applications Using Composite Orbital Angular Momentum Beams
Authors: Zhang Nian , Xiong Baoxing , Zhang Xiang , Yuan Xiao
Published: August 2022

Optical orbital angular momentum (OAM) holography has been developed and implemented as a vital method for optical encryption. However, OAM holography can only be encoded and decoded with an OAM beam, which limits the level of optical encryption. Here, composite OAM beams are introduced using a computer-generated hologram (CGH) for holographic encryption. The target image is encoded with composite helical mode indices, and the OAM holographic image can only be reconstructed under a specific illuminating composite OAM beam. The experimental results are consistent with the theoretical design and numerical simulations, verifying that composite OAM beams can provide a higher security level for optical holographic encryption. The proposed method can be used to enhance anti-counterfeiting applications, secure communication systems, and imaging systems.
Production of the Green Leaf Volatile (Z)-3-Hexenal by a Zea mays Hydroperoxide Lyase
Authors: Yactayo-Chang Jessica P. , Hunter Charles T. , Alborn Hans T. , Christensen Shawn A. , Block Anna K.
Published: August 2022

Plant-produced volatile compounds play important roles in plant signaling and in the communication of plants with other organisms. Many plants emit green leaf volatiles (GLVs) in response to damage or attack, which serve to warn neighboring plants or attract predatory or parasitic insects to help defend against insect pests. GLVs include aldehydes, esters, and alcohols of 6-carbon compounds that are released rapidly following wounding. One GLV produced by maize (Zea mays) is the volatile (Z)-3-hexenal; this volatile is produced from the cleavage of (9Z,11E,15Z)-octadecatrienoic acid by hydroperoxide lyases (HPLs) of the cytochrome P450 CYP74B family. The specific HPL in maize involved in (Z)-3-hexenal production had not been determined. In this study, we used phylogenetics with known HPLs from other species to identify a candidate HPL from maize (ZmHPL). To test the ability of the putative HPL to produce (Z)-3-hexenal, we constitutively expressed the gene in Arabidopsis thaliana ecotype Columbia-0 that contains a natural loss-of-function mutant in AtHPL and examined the transgenic plants for restored (Z)-3-hexenal production. Volatile analysis of leaves from these transgenic plants showed that they did produce (Z)-3-hexenal, confirming that ZmHPL can produce (Z)-3-hexenal in vivo. Furthermore, we used gene expression analysis to show that expression of ZmHPL is induced in maize in response to both wounding and the insect pests Spodoptera frugiperda and Spodoptera exigua. Our study demonstrates that ZmHPL can produce GLVs and highlights its likely role in (Z)-3-hexenal production in response to mechanical damage and herbivory in maize.
Phytochemical Diversity and Antioxidant Potential of Wild Heather (Calluna vulgaris L.) Aboveground Parts
Authors: Kaunaite Vytaute , Vilkickyte Gabriele , Raudone Lina
Published: August 2022

Calluna vulgaris L. (heather) is a traditional medicinal plant with anti-inflammatory and calming activities that are determined by the notable amounts of phytochemicals. The evaluation of different populations of plants that accumulate great amounts of bioactive compounds are requisite for the quality determination of plant materials and medicinal and nutritional products. The assessment of natural resources from a phytogeographic point of view is relevant. Phytochemical analysis of heather samples was carried out using spectrophotometric methods and HPLC-PDA techniques, while antioxidant activity was determined using ABTS and FRAP assays. A significant diversification of phenolic and triterpenic compounds and antioxidant activity was determined in the heather samples collected in distinct habitats. Natural habitats, due to their characteristic chemical heterogeneity, lead to the diversity of indicators characterizing the quality of plant raw materials. Chlorogenic acid and hyperoside were found to be predominant among the phenolic compounds, while ursolic, oleanolic acids, and uvaol prevailed among the triterpenic compounds. Thus, these compounds can be suggested as phytochemical markers, characteristic of the heather raw material from central Europe.
Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents
Authors: Domínguez-Vigil Irma G. , Mata-Cárdenas Benito D. , Esquivel-Ferriño Patricia C. , Avalos-Alanís Francisco G. , Vargas-Villarreal Javier , Camacho-Corona María del Rayo
Published: August 2022

Foeniculum vulgare is used for the treatment of diarrhea in Mexican traditional medicine. Hexane extract showed 94 % inhibition of Giardia duodenalis trophozoites at 300 μg/mL. Therefore, 20 constituents of hexane extract were evaluated to determine their antigiardial activity. Interestingly, six compounds showed good activity toward the parasite. These compounds were (1R,4S) (+)-Camphene (61%), (R)(−)-Carvone (66%), estragole (49%), p-anisaldehyde (67%), 1,3-benzenediol (56%), and trans, trans-2,4-undecadienal (97%). The aldehyde trans, trans-2,4-undecadienal was the most active compound with an IC50 value of 72.11 µg/mL against G. duodenalis trophozoites. This aldehyde was less toxic (IC50 588.8 µg/mL) than positive control metronidazole (IC50 83.5 µg/mL) against Vero cells. The above results could support the use of F. vulgare in Mexican traditional medicine.
Vibration Characteristics Analysis of O-Shaped Damping Ring to Balance Damping Gear Transmission System for Three-Cylinder Engine
Authors: Wang Pingjun , Li Gangyan , Li Xueping
Published: August 2022

Balance shafts are often used to improve the engine vibration characteristics of three-cylinder engines. The balance damping gear with a damping ring is an important part connecting the crankshaft and the balance shaft transmission. The stiffness characteristics of the damping ring and the unbalance of the gear have an important influence on its vibration suppression performance, but the coupled influence of the stiffness characteristics of the damping ring and the unbalanced characteristics of the vibration damping gear is unknown. In this paper, a multi-body dynamic bending–torsional coupling model of the transmission system of a three-cylinder engine with a balance damping gear is constructed considering the equivalent stiffness of the balance shaft support. Based on the fourth-order Runge–Kutta method, the influence laws of different rotational speeds, load torques, gear unbalance, radial stiffness and torsional stiffness of the damping ring on the vibration characteristics of the transmission system are obtained. The results show that the vibration amplitude increases linearly with the increase in the rotational speed and the amount of unbalance. As the load torque increases, the noise radiation of the system increases. The change in the equivalent torsional stiffness of the damping ring has little effect on the radial vibration suppression effect of the gear. As the equivalent radial stiffness of the damping ring increases, the vibration suppression rate decreases linearly. Combined with the calculation formula of damping ring stiffness, when the inner and outer diameters of the damping ring are relatively large, the vibration suppression performance decreases sharply with the increase in the thickness of the damping ring. Therefore, in order to achieve a better vibration attenuation effect, the inner to outer diameter ratio of the damping ring should be given priority in the design of the damping gear. Thus, the thickness of the design can meet the requirements of the vibration attenuation performance and a vibration attenuation of more than 90% of the radial vibration can be achieved. The model of the damping ring size and the vibration suppression effect established based on the method presented in this paper can be used to guide the design of balance damping gears.
Application of a Single Multilayer Perceptron Model to Predict the Solubility of CO2 in Different Ionic Liquids for Gas Removal Processes
Authors: Fierro Elías N. , Faúndez Claudio A. , Muñoz Ariana S. , Cerda Patricio I.
Published: August 2022

In this work, 2099 experimental data of binary systems composed of CO2 and ionic liquids are studied to predict solubility using a multilayer perceptron. The dataset includes 33 different types of ionic liquids over a wide range of temperatures, pressures, and solubilities. The main objective of this work is to propose a procedure for the prediction of CO2 solubility in ionic liquids by establishing four stages to determine the model parameters: (1) selection of the learning algorithm, (2) optimization of the first hidden layer, (3) optimization of the second hidden layer, and (4) selection of the input combination. In this study, a bound is set on the number of model parameters: the number of model parameters must be less than the amount of predicted data. Eight different learning algorithms with (4,m,n,1)-type hidden two-layer architectures (m = 2, 4, …, 10 and n = 2, 3, …, 10) are studied, and the artificial neural network is trained with three input combinations with three combinations of thermodynamic variables such as temperature (T), pressure (P), critical temperature (Tc), critical pressure, the critical compressibility factor (Zc), and the acentric factor (ω). The results show that the 4-6-8-1 architecture with the input combination T-P-Tc-Pc and the Levenberg–Marquard learning algorithm is a very acceptable and simple model (95 parameters) with the best prediction and a maximum absolute deviation close to 10%.
Diet Supplemented With Purslane, Portulaca oleracea Linnaeus, 1753 Resolves Bisphenol A Impact on North African Catfish, Clarias gariepinus (Burchell, 1822)
Authors:   Fish Health Department, Animal Health Research Institute, Agriculture Research Center, Egypt, ABDALLAH HODA MOHAMED LOTFY , MOHAMEDY SAHAR NASR , HAMED ABDALLAH SAID , BAKRY MOHAMED AHMED , ABDELAL MAGDA NEMAT , MEKAWY SOAD
Published: August 2022

Bisphenol A (BPA) is one of the most widely used synthetic compounds in the world. Since BPA is a suspected xenoestrogen and oxidative stressful agent, its potential hazardous impacts were evaluated on the health and the reproductive status of the male North African catfish, Clarias gariepinus (Burchell, 1822). Ninety mature male North African catfish were divided into six groups (in three replicates); Group 1 & Group 4 fed basal diet (control), Group 2 & Group 5 diets supplemented with 3 % purslane, Portulaca oleracea Linnaeus, 1753 powder, and Group 3 & Group 6 diets supplemented with 5 % purslane powder. Group 4, Group 5, and Group 6 were exposed to 50 µg.L-1 BPA for 14 days. Group 4 showed a significant increase in the luteinising hormone, 17β estradiol, and malondialdehyde levels, with a decrease in the testosterone, superoxide dismutase, and catalase concentrations. Simultaneously, there were elevated liver and kidney markers with severe degenerative changes in the testes, liver, and kidney. Dietary supplementation of purslane powder returned the measured parameters to their normal values with the correction of the tissue architectures and details. Interestingly, purslane in the non-BPA treated groups raised the testosterone and 17β estradiol over the control values. It is suggested that purslane could be used in aquaculture and cultivated near polluted water areas.
Perception of Mental Health on Christian College Campuses: A Case Study
Authors: Dinse Ling , Weaver Summer , Gehman Victoria , Esh Nancy , Koeshartono Valerie
Published: August 2022

The perception of mental health directly impacts an individual’s acceptance and utilization of counseling services. Mental health challenges are increasingly common among college students. The purpose of this case study is to examine the perception of mental health and the receptiveness to receiving mental health services among Christian college students. This study surveyed both professors and students from a Christian college in Central Pennsylvania. The two key themes that emerged from this study were a perceived stigma attached to mental health challenges and receiving mental health services and a lack of support from the Christian community. The survey results inform the recommendations including expanding education surrounding mental health and mental health services, accessibility of mental health services, and destigmatizing mental health
Primer İmmün Yetmezlik ve Malignite Birlikteliği: İki Olgu Sunumu
Authors: DİKİCİ Ümmügülsüm , ÖZDEMİR Öner , YILMAZ Emine Aylin , ORHAN Mehmet Fatih
Published: August 2022

Primer immun yetmezlikler tekrarlayan enfeksiyon dışında malignitelere yatkınlık oluşturan hastalıklardır. Primer immun yetmezlikli hastalarda bazı bilinmeyen mekanizmalar ve kusurlu DNA onarım süreçleri nedeniyle oluşan genomik instabilite, kanser riskinde artışa neden olur ve bu hastalarda genel olarak kanser gelişme riskinin % 4,7- 5,7 arasında değiştiği düşünülmektedir. Primer immun yetmezlikli hastaların enfeksiyonlardan sonra en sık ölüm nedeni malignitelerdir. Bu makalede sunmuş olduğumuz ilk olgumuz öksürük şikâyetiyle hastaneye başvuran ve takibinde Burkitt Lenfoma tanısı alan, bu aşamada tetkiklerinde immünglobülinlerinde düşüklük saptanarak lenfoma tanısına eş zamanlı olarak yaygın değişken immün yetmezlik tanısı eklenen hastamızdır. İkinci olgumuz primer immun yetmezlik nedeniyle takipliyken akut lenfoblastik lösemi gelişen hastamızdır. Burada primer immun yetmezlikli hastaların olağanın dışında ilk başvurusunun maligniteyle beraber de olabileceğine dikkat çekmeyi ve primer immun yetmezlikli hasta takip eden klinisyenlerin malignite gelişimine karşı farkındalıklarını arttırmayı amaçladık.
Examination of Underlying Lower Extremity Vascular Pathologies in Patients With Diabetic Foot Infection and Clinical Outcomes
Authors: ŞAHİN Serpil , ALKAN Sevil , ŞENER Alper
Published: August 2022

Objective: Diabetes and vascular disorders raise the risk of diabetic foot infection and lower extremity amputation. Although DFI risk factors and microbiological analyses have been thoroughly researched, data for this specific group is limited. In this study, it was aimed to examine the underlying vascular risk factors of patients who were followed up and treated with the diagnosis of DFIs and clinical outcomes.
Methods: Clinical, demographic, laboratory, microbiological, and foot examination data for 153 patients referred to our center for DFI between 2016 and 2021 were collected retrospectively from hospital information system.
Results: The present center collected a total of 153 DFI patients during 5 year this period. There were 86 male and 67 women with a mean age of 67.71±15 years. There was 104 patients in non-vascular induced DFI group and 49 vascular induced DFI group. The top two comorbidities of DFI patients were cardiovascular disease and hypertension respectively. The rate of male patients was statistically higher in the vascular induced DFI group (p=0.003). Also hypertension and cardiovascular disease were more common in the vascular induced DFI group (p=0.0006, p=0.01). History of extremity amputation/debridement, having Wagner grade 5 DFI and Gram negative microorganism growth in tissue cultures were more common in the vascular induced DFI group (p=0.01, p=0.01 and p=0.0006). Extremity amputation/debridement rates were higher in the vascular induced DFI group (p=0.01)
Conclusion: DFIs cause increased risk of amputation, prolonged antibiotic therapy, increased hospitalization, and increased healthcare costs as a result of investigations. Awareness of the vascular pathologies underlying DFIs can help clinicians manage the disease. The aim of this study is to emphasize the importance of vascular factors.
Reseña de Vidas mediáticas
Authors: Berman Mónica
Published: August 2022

Para hacer honor al libro de Fernández, habría que citarlo en un camino cercano al de Pierre Menard, autor del Quijote, pero no es lo que corresponde al género solicitado por lo cual se renunciará a semejante faena.Empecemos por el principio: el prólogo. Un paratexto que abre, de manera brillante y original, un libro como éste. Sandra Valdettaro y Carlos A. Scolari dialogan sobre el texto, sobre sus objetos, sobre los referentes, sobre el modo en el que José Luis Fernández teje y desteje perspectivas y enlaza, de manera constante, otras disciplinas y tradiciones “sin abandonar la centralidad sociosemiótica”, al decir de Scolari. Sin duda, la conclusión de ambos es que es un libro indispensable en toda biblioteca.Vidas mediáticas, sin duda una denominación amplia, funciona a modo de paraguas en el mejor sentido del término. No es que decide poner debajo de ese cobertor léxico una serie de ambigüedades, sino que, por el contrario, argumenta con eficacia las razones para la expansión terminológica y conceptual.
Pengaruh Pendidikan Kesehatan pada Pengetahuan Keluarga tentang Gejala dan Pencegahan Resiko Stroke
Authors: Pomalango Zulkifli B. , Jusuf Herlina
Published: August 2022

Stroke merupakan penyakit yang serangannya secara tiba-tiba. Informasi melalui penyuluhan kesehatan tentang gejala stroke sangat diperlukan oleh keluarga dalam mengatasi pasien stroke di pre hospital, sehingga pasien segara mendapatkan penanganan yang tepat. Penelitian ini bertujuan untuk mengetahui pengetahuan keluarga tentang stroke, tanda, gejala serta faktor risikonya pada individu yang berisiko terkena stroke, menilai program penyuluhan kesehatan terhadap pengetahuan keluarga merawat pasien yang beresiko. Metode penelitian yakni Studi eksperimen semu, untuk menilai pengetahuan sebelum dan sesudah diberikan penyuluhan kepada keluarga yang memiliki pasien berisiko terkena stroke. Penyuluhan akan dilaksanakan secara tatap muka selama 4 menit oleh peneliti menggunakan media dan hand-out singkat. Penilaian dilakukan dengan pemberian kuesioner. Penelitian akan dilaksanakan di Wilayah Kerja Puskesmas Kota Selatan dan Puskesmas Kabila. Kegiatan ini dilaksanakn oleh 2 orang dosen, yang akan dilaksanakan selama ±2 bulan.

Hasil yang ditargetkan dalam penelitian ini yakni adanya sistem pemberdayaan keluarga dalam mengoptimalkan penanganan manajemen pre hospital pada pasien stroke, yang saat ini penelitian sudah masuk pada tindak lanjut memberikan penyuluhan kesehatan kepada keluarga yang memiliki anggota keluarga beresiko mengalami stroke. Hasi penelitian didapatkan pengetahuan keluarga tentang stroke, tanda, gejala serta faktor risikonya pada individu yang berisiko terkena stroke, menilai program penyuluhan kesehatan signifikan dapat meningkatkan pengetahuan keluarga merawat pasien yang beresiko stroke.
REVISANDO: SEXUALIDAD Y GÉNERO EN LA CULTURA DE IZQUIERDA EN LA ARGENTINA DE LA DÉCADA DE 1980
Authors: López Perea Fedra
Published: August 2022

Durante la década de 1980, sectores de la cultura de izquierda de la Argentina revisaron la propia historia reciente en términos políticos y cotidianos, incluyendo aspectos sexuales y de género. Esas revisiones estuvieron atravesadas por la idea de que había una “crisis de la izquierda” y que era necesario redefinir las características de la militancia. Todo esto se produjo en diálogo con la apertura democrática y el “destape”. Las revistas de la cultura de izquierda fueron espacios en los que se desarrollaron estos debates, se presentaron las posiciones y se esbozaron, en algunos casos, nuevas propuestas. Este artículo recupera esos debates que permiten observar cambios en materia de género y de disidencias sexuales en la cultura de izquierda en la historia reciente.
Diagnóstico para la inserción de agricultoras agroecológicas como proveedoras del canal HORECA
Authors: Rengifo Andrea , Boza Sofía , Pérez María Del Carmen
Published: August 2022

Realizamos un diagnóstico respecto a las posibilidades de inserción de mujeres productoras agroecológicas en un circuito corto de comercialización que tenga como destino el canal HORECA. Para ello, en primer lugar, efectuamos entrevistas a dueños y administradores de restaurantes en la Región de O’Higgins, Chile, para identificar los requisitos de sus proveedores. Asimismo, se realizaron encuestas y entrevistas en profundidad a las agricultoras de la agrupación Madre Tierra Germinando, ubicada en el Secano Costero de la Región de O’Higgins, para caracterizar su situación productiva y comercial actual, junto a sus opiniones respecto a los requisitos del canal HORECA. Mediante una matriz comparativa se cruzó la información respecto a los requisitos del canal HORECA y las características y opiniones de las agricultoras entrevistadas, lo cual evidenció que la diversidad y origen natural es una ventaja de las productoras; sin embargo, garantizar volumen de producción de forma estable, así como el transporte, son los dos requisitos cuyo cumplimiento resulta más complejo. De todos modos, existe una actitud positiva para encontrar soluciones grupales. La generación de relaciones estables basadas en el conocimiento mutuo y la confianza entre las agricultoras y los restaurantes es identificada como esencial.
Memetik Kuramın Sembolik Şehir Silüetlerine Yansıması
Authors: DOĞAN Cem , KANATLI Bade
Published: August 2022

Şehirler için görsel bilginin sembolik tanımı diyebileceğimiz silüetler, morfolojik özellikleriyle birlikte şehrin kimliğini ortaya koymaktadır. Dolayısıyla tarihsel süreç içerisinde oluşan şehirlerin değişimlerini, sembolik silüetler üzerinden gözlemlenebilir. Sembolik silüetler, şehirler için değişimin anlamsal tanımıdır ve kültürel evrimle doğrudan bağlantılıdır. Çünkü şehirlerin sembolik silüetlerindeki değişim kültür tabanlıdır. Kültürel evrimin kuramsal tanımı olan memetik kuram ise, nesiller boyunca insanlar arasında aktarılan kültürel bilgiyi nitelemektedir. Bu bilgiler ışığında çalışmada, kültürel evrimin eşleyici bir yansımasını görebileceğimiz metropol şehirlerdeki sembolik silüetler incelenerek, şehir silüetlerinde oluşan evrimsel yansımaya dair bir bakış açısı geliştirmek amaçlanmaktadır. Bu sebeple, ilk olarak çalışmanın kuramsal çerçevesini oluşturmak için kültürel evrim, memetik kuram, şehir silüetleri ve sembolik silüet konulu çalışmaların alan yazın taraması yapılmıştır. Taramalar sonucu ulaşılan bilgiler doğrultusunda Heylighen’in ortaya koyduğu memetik kuram ölçütleri detaylandırılarak açıklanmıştır. Araştırmanın ikinci aşamasında, alan çalışması olarak seçilen İstanbul şehrinin sembolik silüetini bölgesel olarak ortaya koymak için Üsküdar, Beşiktaş-Kadıköy vapur hattı Avrupa ve Asya yakası bakış açıları ile Fındıklı-MSGSÜ noktalarından çekilen fotoğraflar, dijital çizim teknikleriyle analiz edilerek ortaya koyulmuştur. Ardından, İstanbul şehri ile metropol ve kıyı şehir olması açısından benzer özelliklere sahip New York ve Dubai şehirlerinin sembolik silüetleri, dijital çizim teknikleriyle analiz edilmiştir. Böylece üç şehir memetik kuram ölçütleri çerçevesinde karşılaştırılmıştır. Bu bağlamda, kültürel evrim ve şehirlerin sembolik silüetleri arasındaki değişimin birbirlerine paralel olarak gelişim gösterdiği tespit edilmiştir.
Sistem Informasi Manajemen Arsip Pernikahan Pada Kantor Urusan Agama
Authors: Syahroni Abd. Wahab , Subairi Imam
Published: August 2022

INTISARIPenelitian ini bertujuan untuk mempermudah petugas Kantor Urusan Agama(KUA) bagian pengelolaan pencatatan pernikahan dalam melakukan pengarsipan data pernikahan. Saat ini, pencatatan data arsip pernikahan di KUA Kecamatan Dasuk dan Rubaru Kabupaten Sumenep masih dilakukan secara konvensional, langsung terdokumentasi pada arsip kertas sehingga petugas kesulitan dalam melakukan pencarian data pernikahan serta rekap laporan bulanan dan tahunan. Penelitian ini merancang sistem informasi manajemen arsip pernikahan KUA berbasis web, mulai dari pencatatan calon pasangan hingga pelaksanaan pernikahan akan diarsipkan kedalam aplikasi. Sehingga memudahkan dalam pencarian arsip pernikahan di masa yang akan datang. Aplikasi ini dibangun dengan menggunakan framework Codeigneiter dan MySQL sebagai basis datanya. Terdapat 4 user dalam aplikasi ini antara lain kasi kabupaten, operator kecamatan, penghulu, dan warga. Dengan adanya aplikasi ini, selain pengarsipan data pernikahan yang terdigitalisasi, warga juga dapat melihat status pernikahan orang lain. Aplikasi telah diuji dengan menggunakan metode blackbox testing dengan hasil semua fungsionalitas sistem dapat berjalan dengan baik.. Kata Kunci : KUA, Arsip Nikah, Aplikasi, Blackbox Testing. ABSTRACT This study aims to facilitate the officers of the Office of Religious Affairs (KUA) in the management of marriage records in filing marriage data. Currently, the recording of marriage archive data in KUA, Dasuk and Rubaru Subdistricts, Sumenep Regency is still done conventionally, it is directly documented on paper archives so that officers have difficulty in searching for marriage data and recapitulating monthly and annual reports.This study designed a web-based KUA marriage archive management information system, starting from the recording of the prospective spouse to the implementation of the marriage will be archived into the application. Making it easier to search for marriage archives in the future. This application is built using Codeigneiter framework and MySQL as its database. There are 4 users in this application, including the district head, sub-district operator, headman, and residents. With this application, in addition to archiving digitalized marriage data, residents can also see the marital status of others. The application has been tested using the blackbox testing method with the results of all system functionality running well. Keywords: KUA, Marriage Archives, Applications, Blackbox Testing.
Perancangan Arsitektur Teknologi Informasi pada Perusahaan Agrokompleks Menggunakan Pendekatan TOGAF ADM
Authors: M. Rudyanto Arief Netci Hesvindrati, Wing Wahyu Winarno,
Published: August 2022

AbstrakPerancangan Enterprise Architecture (EA) Teknologi Informasi menggunakan pendekatan TOGAF ADM memberikan panduan setahap demi setahap dalam mensinergikan antara strategi perusahaan dengan pengembangan sistem informasi sebagai key enabler bagi proses bisnis. Penyusunan Arsitektur Enterprise dalam hal ini diterapkan menggunakan metode Action Reseach di sebuah perusahaan Multi Level Marketing produk agrokompleks. Semakin meningkatnya jumlah anggota yang tersebar di seluruh Indonesia dan perlunya peningkatan pelayanan terhadap pelanggan mendorong perusahaan untuk mengembangkan mobile system berbasis Android yang dapat mewakili kebutuhan penyuluhan dan interaksi dengan member secara online.Penelitian Enterprise Architecture dalam mengembangkan kebijakan aplikasi mobile dilakukan dengan pendekatan TOGAF 9.1 Architecture Development Method (ADM) yang diaplikasikan dengan membatasi pada langkah Tahap Preliminary dengan mengumpulkan informasi dan kebutuhan perusahaan; Tahap Arsitektur Visi (Fase A) menerapkan Value Chain Model; Tahap Arsitektur Bisnis (Fase B) menggunakan Use Case Model, dan Tahap Arsitektur Sistem Informasi (Fase C) menggunakan Class Diagram Model, dan Technology Architecture menggunakan Topologi Jaringan.Enterprise Architecture ini telah dapat dijadikan sebuah model untuk meningkatkan pemahaman manajemen dalam pengembangan Sistem Informasi yang saat ini tengah berjalan. TOGAF telah dapat diaplikasikan dalam penyusunan EA untuk pengembangan mobile system berbasis Android.Kata Kunci : Enterprise Architecture, TOGAF 9.1, TOGAF ADM, Use Case, Action Research