bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and Genetic Studies of the First Monozygotic Twins with Pfeiffer Syndrome
Authors: Kantaputra Piranit N. , Angkurawaranon Salita , Khwanngern Krit , Ngamphiw Chumpol , Intachai Worrachet , Adisornkanj Ploy , Tongsima Sissades , Olsen Bjorn , Sonsuwan Nuntigar , Katanyuwong Kamornwan
Published: October 2022

Objective: To report the clinical and radiographic findings and molecular etiology of the first monozygotic twins affected with Pfeiffer syndrome. Methods: Clinical and radiographic examination and whole exome sequencing were performed on two monozygotic twins with Pfeiffer syndrome. Results: An acceptor splice site mutation in FGFR2 (c.940-2A>G) was detected in both twins. The father and both twins shared the same haplotype, indicating that the mutant allele was from their father’s chromosome who suffered severe upper airway obstruction and subsequent obstructive sleep apnea. Hypertrophy of nasal turbinates appears to be a newly recognized finding of Pfeiffer syndrome. Increased intracranial pressure in both twins were corrected early by fronto-orbital advancement with skull expansion and open osteotomy, in order to prevent the more severe consequences of increased intracranial pressure, including hydrocephalus, the bulging of the anterior fontanelle, and the diastasis of suture. Conclusions: Both twins carried a FGFR2 mutation and were discordant for lambdoid synostosis. Midface hypoplasia, narrow nasal cavities, and hypertrophic nasal turbinates resulted in severe upper airway obstruction and subsequent obstructive sleep apnea in both twins. Hypertrophy of the nasal turbinates appears to be a newly recognized finding of Pfeiffer syndrome. Fronto-orbital advancement with skull expansion and open osteotomy was performed to treat increased intracranial pressure in both twins. This is the first report of monozygotic twins with Pfeiffer syndrome.
Spatio-Temporal Variations in the Geochemistry of Laguna Salada de Chiprana, NE Spain
Authors: Doyle Connor , Corella Juan Pablo , Schröder Stefan , Strauss Harald , Bishop Thomas , Yarwood Jonathan , Valero-Garcés Blas
Published: October 2022

Hypersaline lakes are sensitive and increasingly threatened ecological and depositional environments that are host to a diverse spectrum of industrial services, natural resources, and environmental processes. Furthermore, they are also important repositories of high-resolution palaeoenvironmental information and are potentially key archives in the reconstruction of environmental, climatic conditions and past human impacts in areas where other such repositories may not be available. Many saline lakes are threatened by increased farming and irrigation practices and the effects of global warming. Geochemical XRF analyses of a transect of sediment cores from Laguna Salada de Chiprana, a permanent hypersaline lake in the Iberian Peninsula, provide insights into geochemical processes and palaeoenvironmental changes occurring at the site throughout the last 300–400 years. Key changes identified within the sequence are defined both from a spatial and temporal aspect and characterise the profundal and littoral sub-environments of the lake. Initially, the onset of a phase of widespread agriculture and irrigation in the region occurred in the late 16–17th century to ~1850AD and was associated with relative increases in lake levels. This was followed by decreasing lake levels between 1850 and 1950AD, likely associated with increasing evaporative processes and decreased irrigation returns to the lake, which also allowed for increased organic productivity in the profundal setting. This may have been associated with the transition of the site to a wetland-type setting, where biological processes were able to flourish in the shallower central depocentres of the lake. In sequence, the introduction of farm machinery and changing irrigation patterns occurred around 1950, causing small increases in lake levels, colonization by charophytes as well as increased organic productivity in the littoral setting, likely due to the establishment of suitable environments for biological processes to occur in the shallower margins of the lake when water levels rose. From this period to the present day, slow drawdown of the lake has occurred coupled with increasing management of the site by the regional government, leading to several phenomena. Evaporative processes are high throughout the lake; there are falling but highly variable water levels and there is a segmentation of organic productivity, whereby falling lake levels permit increased organic productivity in the profundal setting but decrease productivity in the littoral setting due to the establishment of harsh evaporitic and erosive conditions in this area. The reconstruction reveals the high sensitivity of Lake Chiprana as an environmental archive and illustrates the need to utilise multiple sediment cores for accurate palaeoenvironmental reconstructions of saline lakes due to the strong variability in depositional and geochemical sub-environments.
3D Bayesian Inversion of Potential Fields: The Quebec Oka Carbonatite Complex Case Study
Authors: Sampietro Daniele , Capponi Martina , Maurizio Gerardo
Published: October 2022

Potential fields methods, based on the exploitation of gravity and magnetic fields, are among the most important methods to recover fundamental information on the Earth crust structure at global, regional and local scales. The bottleneck for this kind of geophysical methods is often represented by the development of ad-hoc techniques to fully exploit the available data. In fact, each different technique can observe the effect of a single property of the subsurface and when we want to estimate this property from the observed field (the so-called inverse problem), several problems such as non-uniqueness and instability arise. A possible solution to these problems consists in jointly inverting, in a consistent way, different observed fields, possibly also incorporating all the available geological constraints. In the current work, we present an innovative Bayesian algorithm aimed at performing a full 3D joint inversion of gravity and magnetic fields constrained by geological a-priori qualitative information. The algorithm is tested on a real-case scenario, namely, a local study to estimate a complete 3D model of the Oka carbonatite complex. This complex is a composite pluton in Quebec (Canada), important for mining operations related to critical raw material such as Niobium and other rare earth. This example shows the reliability of the developed inversion algorithm and gives hints on the fundamental role that potential fields can play in mining activities.
Paroxysmal Sustained Ventricular Tachycardia with Cardiac Arrest and Myocardial Infarction in 29-Year-Old Man Addicted to Medical Marijuana—It Never Rains but It Pours
Authors: Wiliński Jerzy , Skwarek Anna , Chrzan Iwona , Zeliaś Aleksander , Borek Radosław , Dykla Dominika Elżbieta , Bober-Fotopoulos Maria , Dudek Dariusz
Published: October 2022

This article presents the case of a 29-year-old male patient, addicted to prescribed medical marijuana administered for mixed anxiety and depressive disorder and without classic cardiovascular risk factors and history of myocarditis, suffering from episodes of paroxysmal hemodynamically unstable ventricular tachycardia. Cardiovascular magnetic resonance imaging of the heart revealed disseminated non-ischemic myocardial injury lesions of subepicardial and intramuscular location. Additionally, the individual experienced myocardial infarction without ST segment elevation following marijuana intake. Treatment required implantation of a cardioverter-defibrillator and ablation of the myocardial areas responsible for the origin of the arrhythmia, as well as appropriate pharmacotherapy and marijuana addiction treatment.
Successful Aging for Community-Dwelling Older Adults: An Experimental Study with a Tablet App
Authors: Chaudhry Beenish Moalla , Dasgupta Dipanwita , Chawla Nitesh V.
Published: October 2022

Mobile health (mHealth) technologies offer an opportunity to enable the care and support of community-dwelling older adults, however, research examining the use of mHealth in delivering quality of life (QoL) improvements in the older population is limited. We developed a tablet application (eSeniorCare) based on the Successful Aging framework and investigated its feasibility among older adults with low socioeconomic status. Twenty five participants (females = 14, mean age = 65 years) used the app to set and track medication intake reminders and health goals, and to play selected casual mobile games for 24 weeks. The Older person QoL and Short Health (SF12v2) surveys were administered before and after the study. The Wilcoxon rank tests were used to determine differences from baseline, and thematic analysis was used to analyze post-study interview data. The improvements in health-related QoL (HRQoL) scores were statistically significant (V=41.5, p=0.005856) across all participants. The frequent eSeniorCare users experienced statistically significant improvements in their physical health (V=13, p=0.04546) and HRQoL (V=7.5, p=0.0050307) scores. Participants reported that the eSeniorCare app motivated timely medication intake and health goals achievement, whereas tablet games promoted mental stimulation. Participants were willing to use mobile apps to self-manage their medications (70%) and adopt healthy activities (72%), while 92% wanted to recommend eSeniorCare to a friend. This study shows the feasibility and possible impact of an mHealth tool on the health-related QoL in older adults with a low socioeconomic status. mHealth support tools and future research to determine their effects are warranted for this population.
Cooperation with Teachers as a Mediator of the Relationship between Family Conflict and Children’s Psychological Difficulties
Authors: Caputi Marcella , Forresi Barbara , Giani Ludovica , Scaini Simona
Published: October 2022

Parent–child conflict can have a series of negative consequences concerning youth emotional and behavioral development. The link between family conflict and children’s externalizing symptoms is well established, whereas the association with internalizing symptoms is less explored. Within the school context, children are engaged in other meaningful relationships (i.e., with teachers and peers) which contribute to their growth. This cross-sectional study aimed at understanding whether a cooperative behavior with the teachers is able to mediate the association between parent–child conflict and children’s psychopathological symptoms. We recruited 319 (150 boys) school-aged children (M = 11.3 years; SD = 1.8 years) and their parents and teachers. Children self-reported on their internalizing symptoms, whereas parents completed a questionnaire concerning their relationship with the child, and teachers rated children’s behavior and internalizing/externalizing symptoms. Analyses conducted through Hayes’ PROCESS tool showed that cooperation with the teacher partially mediated the association between parent–child conflict and child-reported depressive symptoms. Notably, cooperative behavior fully mediated the link between parent–child conflict and children’s internalizing and externalizing symptoms reported by teachers. Difficulties exhibited at school partly derive from a conflictual home environment. Our findings showed that such problems can be reduced thanks to a cooperative relationship with the teacher.
Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study
Authors: Alsen Mathilda , Vasan Vikram , Genden Eric M. , Sinclair Catherine , van Gerwen Maaike
Published: October 2022

The increasing rate of thyroid cancer may be attributable to endocrine disruptive chemicals. Lindane is a persistent organochlorine pesticide with endocrine disruptive properties that has been classified as carcinogenic to humans. The aim of this ecological study was to evaluate potential correlation between lindane exposure and thyroid cancer incidence in the United States (US). Data on statewide age-adjusted thyroid cancer incidence rate (per 100,000 people) was obtained from the Centers for Disease Control and Prevention for all US states for 2019. Lindane use estimates per cropland (kg/acres cropland) were then overlaid on the map of age-adjusted thyroid cancer incidence rate using ArcGIS. The trend of lindane use in the US between 1992 and 2007 was calculated using the Mann Kendall correlation test. The correlation between statewide lindane use and age-adjusted thyroid cancer incidence rates was calculated using Spearman correlation. Lindane use in the US decreased significantly between 1992 and 2007 (T = −0.617; p < 0.001). There was no statistically significant correlation between lindane use in 1992 and thyroid cancer incidence rate for any of the years between 1999 and 2019. Our results suggest that restrictions clearly seem to be effective in reducing lindane use, however, more research is needed for individual pesticides and thyroid cancer.
Site Selection of Urban Parks Based on Fuzzy-Analytic Hierarchy Process (F-AHP): A Case Study of Nanjing, China
Authors: Li Chenying , Zhang Tiantian , Wang Xi , Lian Zefeng
Published: October 2022

The scientific siting of urban parks is critical for sustainable urban environment development, and this study aimed to identify suitable areas for future urban parks in Nanjing, China. This study has integrated geographic information systems (GIS) and fuzzy hierarchical analysis (F-AHP) in order to evaluate the suitability of the site selection of urban parks in Nanjing, China. Different physical, natural, environmental, accessibility, and human activity factors were evaluated in order to assess the suitability of a park site. The results revealed that 5% were highly suitable for urban park site selection, 36% were more suitable, 32% were moderately suitable, 19% were less suitable, and 8% were unsuitable for urban park site selection. The findings suggest that the areas that are highly suitable for urban park placement are located in the western and eastern parts of Nanjing. Carbon storage was the most important factor in the suitability of urban park site selection, followed by the normalized difference vegetation index (NDVI) and the heat-island effect. The methodology that has been adopted in this study helps to improve the methodological framework of combining F-AHP and GIS; in addition, generating urban park site selection maps assists planners and decision-makers in making scientific site selection decisions.
Compliance Checks Decrease Cigarette Sales Rates to Pseudo-Underaged Mystery Shoppers: A Quasi-Experimental Control Group Study
Authors: Feltmann Kristin , Gripenberg Johanna , Elgán Tobias H.
Published: October 2022

To control adherence to age limits regarding sales of tobacco products, Swedish authorities can conduct compliance checks. Compliance checks involve prior information to all retailers, mystery shopping, and subsequent feedback to the retailers. This study investigated whether compliance checks can decrease the rates of cigarette sales to underaged adolescents. Test purchases of cigarettes were conducted using pseudo-underaged mystery shoppers, i.e., 18-year-old adolescents with a younger appearance not carrying ID, to measure the refusal rate and rate of ID checks. Test purchases were conducted at 257 retail outlets in 13 municipalities in Stockholm County at baseline 2017 and follow-up 2019, respectively. In between the measurements, six municipalities (intervention area) conducted compliance checks, and seven municipalities were used as a comparison. Comparing baseline and follow-up, rates of refusal (70.4 to 95.8%) and ID checks (80.3 to 95.8%) improved in the intervention area. In the comparison area, refusal rates increased (80.9 to 85.2%), and ID check rates remained stable (at 86.1%). Significant group × time interaction effects reveal that the rates of refusal and ID checks differently changed in the study areas over time. These results indicate that compliance checks are an effective method to decrease cigarette sales to underaged adolescents.
Immediate Functional Loading with Full-Arch Fixed Implant-Retained Rehabilitation in Periodontal Patients: Clinical Study
Authors: Velasco-Ortega Eugenio , Cracel-Lopes Joao Luis , Matos-Garrido Nuno , Jiménez-Guerra Alvaro , Ortiz-Garcia Ivan , Moreno-Muñoz Jesús , Núñez-Márquez Enrique , Rondón-Romero José Luis , López-López José , Monsalve-Guil Loreto
Published: October 2022

(1) Background. The immediate functional loading of implants is a clinical procedure used for treating periodontal edentulous patients. This clinical study aimed to evaluate the clinical outcomes of the immediate functional loading of implants with fully fixed rehabilitations in compromised periodontal patients. (2) Methods. Three hundred and five implants IPX screw implants were placed in 27 periodontal patients using an immediate functional loading protocol with fixed rehabilitations. All patients had a previous history of periodontitis, four patients (14.8%) were smokers and seven patients (25.9%) suffered from chronic medical conditions. (3) Results. Implant and prosthetic clinical findings were evaluated during a mean period of 41.3 ± 19.6 months. No implants were lost during the clinical follow-up. The cumulative survival rate for all implants was 100%. Regarding the prostheses designed, a total of 54 fixed prostheses were placed in the 27 patients immediately after the surgery. Forty-four hybrid fixed prostheses (81.5%) and 10 fixed rehabilitations (18.5%) were placed in the patients. The mean marginal bone loss was 1.51 ± 1.16 mm, ranging from 0 to 3.5 mm during the follow-up evaluation. Thirty-one implants (10.2%) in 10 patients (37%) were associated with peri-implantitis. Five patients (18.5%) showed some kind of technical complications (loss/fracture of the prosthetic screw, acrylic resin fracture, ceramic chipping). (4) Conclusions. The clinical outcomes of this study demonstrate that fixed rehabilitation by immediate functional loading of implants is considered a predictable procedure.
The Patient’s Voice as a Parent in Mental Health Care: A Qualitative Study
Authors: Stolper Hanna , van Doesum Karin , Henselmans Petra , Bijl Anne Lynn , Steketee Majone
Published: October 2022

Objective: This study is an evaluation of patients in mental health care who have undertaken treatment with an integrated family approach. The treatment focuses on the mental disorders of patients, their role as parents, the development of their young children, and family relationships. The treatment was conducted by professionals from an adult and a child mental health service in the Netherlands. The aim of the study was to identify the key elements and processes of this approach in order to develop a theoretical model. Background: Parental mental disorders have an impact on parenting and child development. To stop detrimental cascade effects and prevent parents and children from being caught up in the intergenerational transmission of psychopathology, a family approach in mental health care is needed. Methods: A qualitative design was adopted using thematic analysis. Data were collected through 18 interviews with patients. The themes in the interviews were which outcomes the patients experienced and which key elements of the treatment contributed to these outcomes. Results: In general, patients were satisfied with the treatment offered. Improved outcomes were within the domain of the family, the parent-child relationship, individual symptoms, and the functioning of the parent and the child. Patients mentioned six key elements of success in treatment: focus on the whole family, flexible treatment tailored to the situation of the family, components of the whole treatment reinforcing each other, multi-disciplinary consultation among involved professionals, a liaison between adult and child mental health services, and attention to the social and economic environment. Conclusions: According to the majority of patients, treatment with an integrated family approach in mental health care is of value for themselves, their children, and family relationships, especially the parent-child relationship.
Disease Progression, Clinical Features, and Risk Factors for Pneumonia in Unvaccinated Children and Adolescents with Measles: A Re-Emerging Disease in Romania
Authors: Turaiche Mirela , Grigoras Mirela Loredana , Bratosin Felix , Bogdan Iulia , Bota Adrian Vasile , Cerbu Bianca , Gurban Camelia Vidita , Wulandari Prima Hapsari , Gurumurthy Srivathsava , Hemaswini Kakarla , Citu Cosmin , Marincu Iosif
Published: October 2022

Measles causes in vaccinated children, with some exceptions, a mild disease, while the unvaccinated can suffer complications that result in serious consequences and even death. Although the introduction of the measles vaccine has reduced the number of cases and the viral spread, the current downward vaccination trend has resulted in the resurgence of the disease. Currently, Romania has a measles vaccination coverage below the 95% safety threshold. Thus, an outbreak started in 2016 and still ongoing in Romania, many cases being identified in the Western region in the pediatric population. Our objective was to conduct a thorough examination of clinical characteristics, evolution, and risk factors in vaccinated and unvaccinated children in this region. To reach our objectives we used a retrospective cohort analysis. The authors reviewed clinical and laboratory data from patients hospitalized at “Victor Babes” Hospital for Infectious Diseases and Pulmonology in Timisoara. We found a total of 136 qualifying cases of measles among the children admitted to this facility. The two comparison groups consisted of 104 children under 10 years and 32 patients between 10 and 18 years. An important characteristic of both study groups was the high prevalence of patients from the Roma ethnicity, which, although represents a minority in Romania, the prevalence was over 40% in the current study. The infection source was in 40.4% of children under 10 years inside the family, while 71.9% of infections in the group of adolescents were isolated (p-value = 0.047). The multivariate risk factor analysis identified as independent risk factors for the development of pneumonia the older age of patients (OR = 1.62), poor nutritional status (OR = 1.25), Roma ethnicity (OR = 2.44), presence of anemia (OR = 1.58), and procalcitonin (OR = 3.09). It is essential to handle these risk factors in a patient with measles, especially in conjunction with an unknown vaccination status. To achieve a vaccination rate greater than 95 percent for Romanian children, measles vaccination awareness must be promoted, moreover in the Roma population. More comprehensive preventative methods must be developed promptly with the objective of eradicating measles in Romania via a vigorous vaccination campaign.
Modeling Community Residents’ Exercise Adherence and Life Satisfaction: An Application of the Influence of the Reference Group
Authors: Song Huimin , Zeng Wei , Zeng Tingting
Published: October 2022

To expand the application area of the reference group and enrich exercise theoretical research, based on Stimulus-Organism-Response (SOR) framework, this study examines the external factors that motivate adherence to exercise. Taking reference group and strategy and cultural fit as the main stimuli, and personal investment and life satisfaction as mediating variables, this study explores the influence of external stimuli on residents’ exercise behavior. In order to enrich the sample size, two surveys of 734 Chinese residents in two cities (Xiamen vs. Fuzhou) were conducted using factor analyses, regression analysis, and t-test analysis. The results indicated that the reference group and strategic and cultural fit as external stimuli impact on residents’ personal investment, life satisfaction and exercise adherence, and that personal investment and life satisfaction as the organism has an impact on residents’ exercise adherence. Personal investment and life satisfaction play a chain mediating role between the reference group and exercise adherence, and between strategy and cultural fit and exercise adherence. Moreover, the t-test determined the differences between Xiamen and Fuzhou residents’ exercise adherence and life satisfaction. Residents’ surroundings affect their exercise behavior and life satisfaction. These findings have implications for policymaking aimed at promoting national exercise, which could gradually improve residents’ physical fitness, particularly in light of the current coronavirus emergency.
Microcystins in Water: Detection, Microbial Degradation Strategies, and Mechanisms
Authors: He Qianqian , Wang Weijun , Xu Qianqian , Liu Zhimin , Teng Junhui , Yan Hai , Liu Xiaolu
Published: October 2022

Microcystins are secondary metabolites produced by some cyanobacteria, a class of cyclic heptapeptide toxins that are stable in the environment. Microcystins can create a variety of adverse health effects in humans, animals, and plants through contaminated water. Effective methods to degrade them are required. Microorganisms are considered to be a promising method to degrade microcystins due to their high efficiency, low cost, and environmental friendliness. This review focuses on perspectives on the frontiers of microcystin biodegradation. It has been reported that bacteria and fungi play an important contribution to degradation. Analysis of the biodegradation mechanism and pathway is an important part of the research. Microcystin biodegradation has been extensively studied in the existing research. This review provides an overview of (1) pollution assessment strategies and hazards of microcystins in water bodies and (2) the important contributions of various bacteria and fungi in the biodegradation of microcystins and their degradation mechanisms, including mlr gene-induced (gene cluster expressing microcystinase) degradation. The application of biodegradable technology still needs development. Further, a robust regulatory oversight is required to monitor and minimize MC contamination. This review aims to provide more references regarding the detection and removal of microcystins in aqueous environments and to promote the application of biodegradation techniques for the purification of microcystin-contaminated water.
A New Model Algorithm for Estimating the Inhalation Exposure Resulting from the Spraying of (Semi)-Volatile Binary Liquid Mixtures (SprayEva)
Authors: Tischer Martin , Meyer Jessica
Published: October 2022

The spraying of liquid multicomponent mixtures is common in many professional and industrial settings. Typical examples are cleaning agents, additives, coatings, and biocidal products. In all of these examples, hazardous substances can be released in the form of aerosols or vapours. For occupational and consumer risk assessment in regulatory contexts, it is therefore important to know the exposure which results from the amount of chemicals in the surrounding air. In this research, a mechanistic mass balance model has been developed that covers the spraying of (semi)-volatile substances, taking into account combined exposure to spray mist, evaporation from droplets, and evaporation from surfaces as well as the nonideal behaviour of components in liquids and backpressure effects. For wall-spraying scenarios, an impaction module has been developed that quantifies the amount of overspray and the amount of material that lands on the wall. Mechanistically, the model is based on the assumption that continuous spraying can be approximated by a number of sequentially released spray pulses, each characterized by a certain droplet size, where the total aerosol exposure is obtained by summation over all release pulses. The corresponding system of differential equations is solved numerically using an extended Euler algorithm that is based on a discretisation of time and space. Since workers typically apply the product continuously, the treated area and the corresponding evaporating surface area grows over time. Time-dependent concentration gradients within the sprayed liquid films that may result from different volatilities of the components are therefore addressed by the proposed model. A worked example is presented to illustrate the calculated exposure for a scenario where aqueous solutions of H2O2 are sprayed onto surfaces as a biocidal product. The results reveal that exposure to H2O2 aerosol reaches relevant concentrations only during the spraying phase. Evaporation from sprayed surfaces takes place over much longer time periods, where backpressure effects caused by large emission sources can influence the shape of the concentration time curves significantly. The influence of the activity coefficients is not so pronounced. To test the plausibility of the developed model algorithm, a comparison of model estimates of SprayExpo, SprayEva, and ConsExpo with measured data is performed. Although the comparison is based on a limited number (N = 19) of measurement data, the results are nevertheless regarded as supportive and acceptable for the plausibility and predictive power of SprayEva.
Aging and Possible Benefits or Negatives of Lifelong Endurance Running: How Master Male Athletes Differ from Young Athletes and Elderly Sedentary?
Authors: Vajda Matej , Oreská Ľudmila , Černáčková Alena , Čupka Martin , Tirpáková Veronika , Cvečka Ján , Hamar Dušan , Protasi Feliciano , Šarabon Nejc , Zampieri Sandra , Löfler Stefan , Kern Helmut , Sedliak Milan
Published: October 2022

Regular physical activity, recommended by the WHO, is crucial in maintaining a good physical fitness level and health status and slows down the effects of aging. However, there is a lack of knowledge of whether lifelong endurance running, with a volume and frequency above the WHO limits, still brings the same benefits, or several negative effects too. The present study aims to examine the protentional benefits and risks of lifelong endurance running training in Master male athletes, as this level of physical activity is above the WHO recommendations. Within the study, four main groups of participants will be included: (1) endurance-trained master athletes, (2) endurance-trained young athletes, (3) young sedentary adults, and (4) elderly sedentary. Both groups of athletes are strictly marathon runners, who are still actively running. The broad spectrum of the diagnostic tests, from the questionnaires, physical fitness testing, and blood sampling to muscle biopsy, will be performed to obtain the possibility of complexly analyzing the effects of lifelong endurance physical activity on the human body and aging. Moreover, the study will try to discover and explain new relationships between endurance running and diagnostic parameters, not only within aging.
The Effect of FIFA 11+ on the Isometric Strength and Running Ability of Young Soccer Players
Authors: Zhou Xin , Luo Anmin , Wang Yifei , Zhang Qingqing , Zha Yu , Wang Sicheng , Ashton Caroline , Andamasaris John Ethan , Wang Henry , Wang Qirong
Published: October 2022

Soccer is the world’s game, and keeping athletes healthy while playing the game has often been a focus of study. There is a high occurrence of musculoskeletal injuries reported in soccer. FIFA 11+ was developed as an intervention to help prevent such injuries. FIFA 11+ has previously been studied for its efficacy as an injury prevention program, but not for its effect on sports performance in an adolescent population. The purpose of this study was to look at the effect of implementing the FIFA 11+ intervention on strength, speed, and agility. Twenty youth soccer players were randomly divided into an intervention group (INT) and a control group (CON). The intervention lasted for eight weeks and performance assessments were completed pre- and post-intervention. Post-test INT knee flexor strength was significantly higher than pre-test scores (p < 0.05). INT also demonstrated significantly higher hamstring to quadriceps strength ratio (H/Q) after the intervention (p < 0.05), while the CON H/Q did not change significantly. 30-m sprint performance of both groups improved from pre- to post-test (p < 0.05). Shuttle run performance was significantly improved in post-test scores for INT players (p < 0.05), but did not change significantly for the CON players. It is suggested that implementing FIFA 11+ before training in young soccer players can lead to performance benefits as well as injury prevention benefits.
Presentations to the Emergency Department for Problems Related to Mental Health: Sex Differences in Adolescents
Authors: Flury Raffaela M. , Brockhus Lara , Müller Martin , Henssler Jonathan , Exadaktylos Aristomenis K. , Klukowska-Rötzler Jolanta
Published: October 2022

Background: Adolescents aged sixteen to eighteen years are mostly treated in adult emergency departments. In a study at our tertiary adult emergency department (ED) at the University Hospital in Bern (Inselspital), Switzerland, we found that adolescents significantly more often present with psychiatric problems than adults. The study at hand aimed to characterise those adolescents presenting to the ED triaged with a chief complaint regarding mental health. Furthermore, the goal was to assess sex differences in terms of diagnosis, suicidal ideation, substance use, as well as social impact. Methods: We conducted a single-centre, retrospective review of presentations to our adult ED related to the mental health of adolescents aged 16 to 18 years, covering the period from January 2013 to July 2017. Anonymised data were extracted from medical reports referring to the ED visits that were triaged as mental-health-related, and we assessed these for diagnosis, acute and previous suicidal ideation, history of self-harm, external aggression, substance use and social problems. We focused on patient characterisation and defining sex differences. Results: Data were analysed for a total of 612 consultations by adolescents who presented to our ED with problems related to mental health. Women accounted for 61.1% of cases. The most frequent diagnoses were reactions to severe stress and adjustment disorders (19.1%), followed by alcohol use disorders (17.6%), intentional self-harm (17.3%), and affective disorders (13.7%). Males had lower odds for intentional self-harm (OR 0.10, 95% 0.05–0.21, p < 0.001) as well as disorders of personality and behaviour (OR 0.09, 95% 0.21–0.37, p < 0.001), whereas they had higher odds of being admitted due to use of alcohol (OR 2.51, 95% 1.65–3.83, p < 0.001). Of all cases, 31.7% reported acute suicidal ideation, with a significantly lower odds ratio in males (OR 0.58, 95% 0.41–0.84, p = 0.004). The most common source for referral to the ED was family members (25.2%). Males had twice the odds of reporting alcohol consumption as well as use of cannabis (in both cases p < 0.001). In 27.9% of all cases, familial problems were reported, with males having significantly lower odds of being exposed to these (OR 0.64, 95% 0.44–0.94, p = 0.021), whereas they had higher odds of reporting educational problems (OR 1.68, 95% 1.04–2.72, p = 0.035). Conclusions: Adolescents aged sixteen to eighteen years presenting to the ED with problems related to mental health are an important subgroup of ED presentations and should be thoroughly assessed for suicidal ideation, substance use, as well as familial and educational problems. Assessment and establishment of post-ED care are of particular importance in this vulnerable patient group.
Successful Aging among Immigrant and Canadian-Born Older Adults: Findings from the Canadian Longitudinal Study on Aging (CLSA)
Authors: Ho Mabel , Pullenayegum Eleanor , Burnes David , Fuller-Thomson Esme
Published: October 2022

Background: Few studies in Canada have focused on the relationship between immigrant status and successful aging. The concept of successful aging used in this study includes the ability to accomplish both activities of daily living (ADLs) and instrumental activities of daily living (IADLs), freedom from mental illness, memory problems and disabling chronic pain, adequate social support and older adults’ self-reported happiness and subjective perception of their physical health, mental health and aging process as good. Methods: The present study analyzed the first two waves of data from the comprehensive cohort of the Canadian Longitudinal Study on Aging (CLSA). The sample includes 7651 respondents aged 60+ at time 2, of whom 1446 respondents were immigrants. Bivariate and multivariable binary logistic regression analyses were conducted. Results: Canadian-born older adults had a slightly higher prevalence and age-sex adjusted odds of achieving successful aging than their immigrant counterparts (aOR = 1.18, 95% CI: 1.04, 1.34, p < 0.001). After adjusting for 18 additional factors, immigrant status remained statistically significant (aOR = 1.24, 95% CI: 1.09, 1.41, p < 0.001). Significant baseline factors associated with successful aging among immigrants included being younger, having higher income, being married, not being obese, never smoking, engaging in moderate or strenuous physical activities, not having sleeping problems and being free of heart disease or arthritis. Conclusions: Immigrant older adults had a lower prevalence of successful aging than their Canadian-born peers. Further research could investigate whether policies and interventions supporting older immigrants and promoting a healthy lifestyle enhance older adults achieve successful aging in later life.
Comparison of Effects of Storage at Different Temperatures in a Refrigerator, Upright Freezer on Top of Refrigerator, and Deep Freezer on the Immunoglobulin A Concentration and Lysozyme Activity of Human Milk
Authors: Li Xuejing , Siviroj Penprapa , Ruangsuriya Jetsada , Phanpong Chotiros , Sirikul Wachiranun , Ongprasert Krongporn
Published: October 2022

This study aimed to investigate the effects of storing expressed human milk (HM) at different domestic storage temperatures on the secretory immunoglobulin A (SIgA) concentration and lysozyme activity. Forty mothers of full-term infants aged one to six months provided milk samples. The fresh samples were examined within 24 h of expression, and the other samples were stored in a refrigerator for four days or in two types of freezers for six months. The SIgA concentrations and lysozyme activity in the milk samples were studied using enzyme-linked immunosorbent assay (ELISA) kits and fluorometric lysozyme activity assay kits, respectively. The pairwise comparisons of the SIgA concentration and lysozyme activity were carried out using one-way analysis of variance with Dunnett T3 or Kruskal–Wallis tests with Bonferroni correction, depending on the data distribution. The mean temperatures of the refrigerator, upright freezer on top of the refrigerator, and deep freezer (chest freezer) were 2.0, −16.7, and −22.3 °C, respectively. Our study results highlight that the SIgA concentration and lysozyme activity of HM stored in the refrigerator for four days and in freezers for six months were significantly lower than those of fresh HM (p < 0.001). During the first six months of storage in both types of freezers, the SIgA levels were stable, whereas the lysozyme activity significantly decreased (p < 0.001). HM stored in the deep freezer had a higher SIgA concentration and lysozyme activity than HM stored in the upright freezer on top of the refrigerator. Our data support the superiority of fresh human milk over stored HM. If HM is to be stored, then storage in a deep freezer is potentially a more effective method for the preservation of SIgA concentrations and lysozyme activity than storage by refrigeration for four days or in an upright freezer on top of a refrigerator for six months.
Factors Associated with Using Telemedicine in the Primary Care Clinics during the COVID-19 Pandemic in Israel
Authors: Reges Orna , Feldhamer Ilan , Wolff Sagy Yael , Lavie Gil
Published: October 2022

Background: The COVID-19 pandemic generated an extraordinary need for telemedicine. Objective: To identify the factors and multi-way interactions associated with telemedicine use in primary healthcare during the COVID-19 pandemic. Methods: This population-based study included all members (2,722,773) aged ≥18 years of the largest healthcare organization in Israel who used primary care clinic services between 1 March 2020 and 31 December 2021. Individuals were classified as telemedicine users (≥1 phone/video visits or asynchronous encounters) or non-telemedicine users (only in-person encounter/s). Results: Ethnicity was the most discriminative variable associated with telemedicine use, with 85% and 52% users among Jews and Arabs, respectively. Higher odds for telemedicine utilization were observed among women, residents of urban areas, those confined to home, individuals with high level of technology literacy, residents of the central area (in Jews only), young Jews, and older Arabs. Based on decision tree analysis, the segments of the population with the lowest telemedicine use were characterized by lower primary care needs and comorbidities, as well as low technology literacy. The proportion of telemedicine use in these groups was 56% and 27% in Jews and in Arabs, respectively. Conclusion: A proactive intervention program should be applied among populations who are less likely to use telemedicine in the primary care clinics, including Arabs, Jews who live in the distant periphery, and individuals with low technology literacy.
Association between Sociodemographic Factors, Coverage and Offer of Health Services with Mortality Due to Oral and Oropharyngeal Cancer in Brazil: A 20-Year Analysis
Authors: Affonso Márcio Vinicius de Gouveia , Souza Igor Gonçalves , Rocha Emerson Souza de , Goloni-Bertollo Eny Maria , Gomes Fabiana de Campos , Nascimento Liliane Silva do , Melo-Neto João Simão de
Published: October 2022

To investigate the association between sociodemographic factors and variables related to oral health services in oral and oropharyngeal cancer mortality in Brazil, between 2000 and 2019. This study had an ecological design. Standardized mortality rates were compared between age group, sex, and regions. Age–Period–Cohort analysis was applied. Oral health services variables were analyzed in correlation tests. Survival analysis included Kaplan–Meier estimators, log-rank tests, and Cox regression. The mortality rate increased with age and was higher in men. Southeast and south regions had the highest rates for men, and the northeast and southeast had it for women. Age–Period–Cohort analysis showed a slight increase in female deaths and an increasing trend in the annual percent change in mortality for men over age 55. In survival analysis, males, Black individuals and southern residents were more strongly associated with death. The correlation between oral health teams’ coverage was high and negative, while the number of dental specialty centers and soft tissue biopsies had a high and positive correlation. Mortality and survival patterns were dependent on sex, age, geographic region and race/ethnicity. It was observed that preventive and diagnostic procedures were not being performed, which may be related to the increase in mortality.
Market Reaction to Local Attention around Earnings Announcements in China: Evidence from Internet Search Activity
Authors: Chen Qian , Gao Xiang , Mo Jianming , Xu Zhouling
Published: October 2022

The existing literature shows that, due to locality and familiarity, spatial investor–firm adjacency plays a key role in determining stock investor attention, as proxied by the location where investors initiate an Internet search of the ticker symbol. This paper investigates whether Chinese stock markets exhibit the same pattern observed in the U.S. market—demand for a firm’s information can exert strong effects on the stock market response during earnings announcements of the firm. Specifically, for each Chinese publicly listed firm, this paper constructs a dynamic local attention ratio that divides the search volume generated within the province where the firm is registered by the contemporaneous nationwide search volume consisting of 31 provinces in total. During 2011–2018 in China’s A-share market, it was found that the local attention measure leads the market response around annual earnings announcement dates. For firms with higher local attention, trading is more active before the announcement, and the price changes can better predict incoming earnings news. At the announcement, while trading remains active, the predictivity of price changes for earnings becomes weaker. Furthermore, we only found evidence that supports the local information advantage argument in explaining the locality of Chinese investors’ attention.
Iron-Sepiolite High-Performance Magnetorheological Polishing Fluid with Reduced Sedimentation
Authors: Milde Radoslav , Moucka Robert , Sedlacik Michal , Pata Vladimir
Published: October 2022

A sedimentation-stable magnetorheological (MR) polishing slurry on the basis of ferrofluid, iron particles, Al2O3, and clay nanofiller in the form of sepiolite intended for MR polishing has been designed, prepared, and its polishing efficiency verified. Added clay substantially improved sedimentation stability of the slurry, decreasing its sedimentation rate to a quarter of its original value (1.8 to 0.45 mg s−1) while otherwise maintaining its good abrasive properties. The magnetisation curve measurement proved that designed slurry is soft magnetic material with no hysteresis, and its further suitability for MR polishing was confirmed by its magnetorheology namely in the quadratically increased yield stress due to the effect of applied magnetic field (0 to 600 kA m−1). The efficiency of the MR polishing process was tested on the flat samples of injection-moulded polyamide and verified by surface roughness/3D texture measurement. The resulting new composition of the MR polishing slurry exhibits a long-term stable system with a wide application window in the MR polishing process.
Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease
Authors: Qiu Min , Chen Jimei , Li Xiaohong , Zhuang Jian
Published: October 2022

Cardiovascular diseases (CVDs) present a major social problem worldwide due to their high incidence and mortality rate. Many pathophysiological mechanisms are involved in CVDs, and oxidative stress plays a vital mediating role in most of these mechanisms. The ubiquitin–proteasome system (UPS) is the main machinery responsible for degrading cytosolic proteins in the repair system, which interacts with the mechanisms regulating endoplasmic reticulum homeostasis. Recent evidence also points to the role of UPS dysfunction in the development of CVDs. The UPS has been associated with oxidative stress and regulates reduction–oxidation homeostasis. However, the mechanisms underlying UPS-mediated oxidative stress’s contribution to CVDs are unclear, especially the role of these interactions at different disease stages. This review highlights the recent research progress on the roles of the UPS and oxidative stress, individually and in combination, in CVDs, focusing on the pathophysiology of key CVDs, including atherosclerosis, ischemia–reperfusion injury, cardiomyopathy, and heart failure. This synthesis provides new insight for continued research on the UPS–oxidative stress interaction, in turn suggesting novel targets for the treatment and prevention of CVDs.