bluuebunny/crossref_metadata_2025 huggingface dataset:
Global Media Ethics
Authors: Ward Stephen J. A.
Published: March 2020

Global media ethics is the study and application of the norms that should guide the responsible use of informational public media that is now global in content, reach, and impact. Its aim is to define responsible use of the freedom to publish for journalism, online commentary, political advocacy, and social media. Global media ethics proposes aims, principles, and norms for global media work, and pays special attention to coverage of global issues such as climate change, immigration, and terrorism. The primary principles tend to stress media protection and advancement of human rights, human development, and global social justice. However, “global media ethics” does not refer to something clear, singular, or established. There is no one code of global media ethics. Global media ethics is a work in progress, a contested zone where globalists advance rival ideas, while skeptics dismiss global ethics as a dream that can never be realized.

Among the conceptual challenges of constructing a global media ethics is the issue of whether universal values exist in media practice around the world, how an appeal to global values can avoid cultural imperialism, such as imposing Western values on non-Western cultures, and to what extent media practitioners can find common ethical ground. Much theorizing in the field of global media ethics discusses forms of cross-border ethical dialogue that are likely to produce fair and inclusive agreement on principles among practitioners. Ultimately, the main questions for global media ethics are: (1) How should the aims and roles of journalism and informational media be redefined given the fact that media is now global? (2) What are the principles for global media and how do they apply to nonprofessional online writers? (3) How does global media ethics alter existing practice, especially the coverage of global issues? And (4) By what methods would such an ethic be constructed, endorsed, and implemented in practice?
Social Identity in Decisions to Protest
Authors: Klandermans Bert , Stekelenburg J. Van
Published: March 2020

Social identity processes play a crucial role in the dynamics of protest, whether as antecedents, mediators, moderators, or consequences. Yet, identity did not always feature prominently in the social or political psychology of protest. This has changed—a growing contingent of social and political psychologists is involved now in studies of protest behavior, and in their models the concept of identity occupies a central place. Decades earlier students of social movements had incorporated the concept of collective identity into their theoretical frameworks. The weakness of the social movement literature on identity and contention, though, was that the discussion remained predominantly theoretical. Few seemed to bother about evidence. Basic questions such as how collective identity is formed and becomes salient or politicized were neither phrased nor answered. Perhaps social movement scholars did not bother too much because they tend to study contention when it takes place and when collective identities are already formed and politicized.

Collective identity in the social movement literature is a group characteristic in the Durkheimian sense. Someone who sets out to study that type of collective identity may look for such phenomena as the group’s symbols, its rituals, and the beliefs and values its members share. Groups differ in terms of their collective identity. The difference may be qualitative, for example, being an ethnic group rather than a gender group; or quantitative, that is, a difference in the strength of collective identity. Social identity in the social psychological literature is a characteristic of a person. It is that part of a person’s self-image that is derived from the groups he or she is a member of. Social identity supposedly has cognitive, evaluative, and affective components that are measured at the individual level. Individuals differ in terms of social identity, again both qualitatively (the kind of groups they identify with) and quantitatively (the strength of their identification with those groups). The term “collective identity” is used to refer to an identity shared by members of a group or category. Collective identity politicizes when people who share a specific identity take part in political action on behalf of that collective.

The politicization of collective identity can take place top-down (organizations mobilize their constituencies) or bottom-up (participants in collective action come to share an identity). In that context causality is an issue. What comes first? Does identification follow participation, or does participation follow identification?
Responding to Adverse Childhood Experiences Across the Lifespan
Authors: Larkin Heather , LaBrenz Catherine , Oby Stephen , Gerlach Beth , Lee Eunju , Briar-Lawson Katharine , Good Lisa
Published: March 2020

The adverse childhood experiences (ACE) study, including long-term health implications, is reviewed, followed by an overview of community approaches to addressing ACEs by building resilience in programs and communities. The restorative integral support (RIS) model embodies social work’s person-in-environment perspective and offers a framework to understand and respond to ACEs and their consequences. Social work’s role in addressing ACEs includes the importance of cross-disciplinary, interprofessional, and community-engaged strategies to enact community and system-wide change. Policy and practice implications to foster a culture of health and well-being are emphasized.
Attentional multi-level representation encoding based on convolutional and variance autoencoders for lncRNA–disease association prediction
Authors: Sheng Nan , Cui Hui , Zhang Tiangang , Xuan Ping
Published: March 2020

As the abnormalities of long non-coding RNAs (lncRNAs) are closely related to various human diseases, identifying disease-related lncRNAs is important for understanding the pathogenesis of complex diseases. Most of current data-driven methods for disease-related lncRNA candidate prediction are based on diseases and lncRNAs. Those methods, however, fail to consider the deeply embedded node attributes of lncRNA–disease pairs, which contain multiple relations and representations across lncRNAs, diseases and miRNAs. Moreover, the low-dimensional feature distribution at the pairwise level has not been taken into account. We propose a prediction model, VADLP, to extract, encode and adaptively integrate multi-level representations. Firstly, a triple-layer heterogeneous graph is constructed with weighted inter-layer and intra-layer edges to integrate the similarities and correlations among lncRNAs, diseases and miRNAs. We then define three representations including node attributes, pairwise topology and feature distribution. Node attributes are derived from the graph by an embedding strategy to represent the lncRNA–disease associations, which are inferred via their common lncRNAs, diseases and miRNAs. Pairwise topology is formulated by random walk algorithm and encoded by a convolutional autoencoder to represent the hidden topological structural relations between a pair of lncRNA and disease. The new feature distribution is modeled by a variance autoencoder to reveal the underlying lncRNA–disease relationship. Finally, an attentional representation-level integration module is constructed to adaptively fuse the three representations for lncRNA–disease association prediction. The proposed model is tested over a public dataset with a comprehensive list of evaluations. Our model outperforms six state-of-the-art lncRNA–disease prediction models with statistical significance. The ablation study showed the important contributions of three representations. In particular, the improved recall rates under different top $k$ values demonstrate that our model is powerful in discovering true disease-related lncRNAs in the top-ranked candidates. Case studies of three cancers further proved the capacity of our model to discover potential disease-related lncRNAs.
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions
Authors: Fransen Nina L , Hsiao Cheng-Chih , van der Poel Marlijn , Engelenburg Hendrik J , Verdaasdonk Kim , Vincenten Maria C J , Remmerswaal Ester B M , Kuhlmann Tanja , Mason Matthew R J , Hamann Jörg , Smolders Joost , Huitinga Inge
Published: March 2020

Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion activity declines. We recently showed in the Netherlands Brain Bank multiple sclerosis-autopsy cohort considerable ongoing inflammatory lesion activity also at the end stage of the disease, based on microglia/macrophage activity. We have now studied the role of T cells in this ongoing inflammatory lesion activity in chronic multiple sclerosis autopsy cases. We quantified T cells and perivascular T-cell cuffing at a standardized location in the medulla oblongata in 146 multiple sclerosis, 20 neurodegenerative control and 20 non-neurological control brain donors. In addition, we quantified CD3+, CD4+, and CD8+ T cells in 140 subcortical white matter lesions. The location of CD8+ T cells in either the perivascular space or the brain parenchyma was determined using CD8/laminin staining and confocal imaging. Finally, we analysed CD8+ T cells, isolated from fresh autopsy tissues from subcortical multiple sclerosis white matter lesions (n = 8), multiple sclerosis normal-appearing white matter (n = 7), and control white matter (n = 10), by flow cytometry. In normal-appearing white matter, the number of T cells was increased compared to control white matter. In active and mixed active/inactive lesions, the number of T cells was further augmented compared to normal-appearing white matter. Active and mixed active/inactive lesions were enriched for both CD4+ and CD8+ T cells, the latter being more abundant in all lesion types. Perivascular clustering of T cells in the medulla oblongata was only found in cases with a progressive disease course and correlated with a higher percentage of mixed active/inactive lesions and a higher lesion load compared to cases without perivascular clusters in the medulla oblongata. In all white matter samples, CD8+ T cells were located mostly in the perivascular space, whereas in mixed active/inactive lesions, 16.3% of the CD8+ T cells were encountered in the brain parenchyma. CD8+ T cells from mixed active/inactive lesions showed a tissue-resident memory phenotype with expression of CD69, CD103, CD44, CD49a, and PD-1 and absence of S1P1. They upregulated markers for homing (CXCR6), reactivation (Ki-67), and cytotoxicity (GPR56), yet lacked the cytolytic enzyme granzyme B. These data show that in chronic progressive multiple sclerosis cases, inflammatory lesion activity and demyelinated lesion load is associated with an increased number of T cells clustering in the perivascular space. Inflammatory active multiple sclerosis lesions are populated by CD8+ tissue-resident memory T cells, which show signs of reactivation and infiltration of the brain parenchyma.
Neither white nor black: embracing clinical variability in dementia diagnosis
Authors: Piguet Olivier
Published: March 2020

This scientific commentary refers to ‘Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes’, by Murley etal. (doi:10.1093/brain/awaa097).
Application of Combined Genomic and Transfer Analyses to Identify Factors Mediating Regional Spread of Antibiotic-resistant Bacterial Lineages
Authors: Wang Joyce , Foxman Betsy , Pirani Ali , Lapp Zena , Mody Lona , Snitkin Evan S
Published: March 2020

Background

Patients entering nursing facilities (NFs) are frequently colonized with antibiotic-resistant organisms (AROs). To understand the determinants of ARO colonization on NF admission, we applied whole-genome sequencing to track the spread of 4 ARO species across regional NFs and evaluated patient-level characteristics and transfer acute care hospitals (ACHs) as risk factors for colonization.

Methods

Patients from 6 NFs (n = 584) were surveyed for methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis/faecium (VREfc/VREfm), and ciprofloxacin-resistant Escherichia coli (CipREc) colonization. Genomic analysis was performed to quantify ARO spread between NFs and compared to patient-transfer networks. The association between admission colonization and patient-level variables and recent ACH exposures was examined.

Results

The majority of ARO isolates belonged to major healthcare-associated lineages: MRSA (sequence type [ST] 5); VREfc (ST6); CipREc (ST131), and VREfm (clade A). While the genomic similarity of strains between NF pairs was positively associated with overlap in their feeder ACHs (P < .05 for MRSA, VREfc, and CipREc), limited phylogenetic clustering by either ACH or NF supported regional endemicity. Significant predictors for ARO colonization on NF admission included lower functional status and recent exposure to glycopeptides (adjusted odds ratio [aOR], > 2 for MRSA and VREfc/VREfm) or third-/fourth-generation cephalosporins (aOR, > 2 for MRSA and VREfm). Transfer from specific ACHs was an independent risk factor for only 1 ARO/ACH pair (VREfm/ACH19: aOR, 2.48).

Conclusions

In this region, healthcare-associated ARO lineages are endemic among connected NFs and ACHs, making patient characteristics more informative of NF admission colonization risk than exposure to specific ACHs.
Better decisions for food security? Critical reflections on the economics of food choice and decision-making in development economics
Authors: Stevano Sara , Johnston Deborah , Codjoe Emmanuel
Published: March 2020

With malnutrition recognised as a key public health issue, attention has been placed on how individuals can make better decisions to attain food and nutrition security. Nevertheless, food practice entails a complex set of decisions that are not fully understood. This paper interrogates the focus on food choice by investigating how socio-economic relations shape practices of food provisioning. Given the surge of behavioural approaches in development economics and our focus on a middle-income country, we contextualise food choice in the transformations of the conceptualisations of decision-making in development economics. We draw on mixed-method evidence on food consumption practices among schoolchildren in Accra, Ghana. We find that the food decision-making process is complex in that it entails multiple moments and people, and embodies contradictory motivations. Decisions are negotiated outcomes reflecting social relations of power among the actors involved. Socio-economic inequality fragments the urban food environment and material living conditions. Furthermore, the concentration of capital gives the food industry the power to shape material and cultural relations to food in ways that extraordinarily limit the scope for individual choice. This is a critical case study to understand the contemporary dynamics of malnutrition in the urban Global South, with broader relevance for the analysis of food poverty elsewhere.
Intradialytic hypotension and relationship with cognitive function and brain morphometry
Authors: Cedeño Santiago , Desco Manuel , Aleman Yasser , Macías Nicolás , Fernández-Pena Alberto , Vega Almudena , Abad Soraya , López-Gómez Juan Manuel
Published: March 2020

Background

The haemodynamic stress brought about by dialysis could justify the loss of structural and functional integrity of the central nervous system (CNS). The main objective of this study was to analyse the relationship between intradialytic hypotension (IDH) and cognitive function and brain morphometry.

Methods

The cross-sectional KIDBRAIN study (Cohort Study of Morphological Changes of the Brain by MRI in Chronic Kidney Disease Patients) included 68 prevalent patients with no history of neurological disorders (cerebrovascular disease and cognitive impairment) undergoing haemodialysis (HD). We analysed 18 non-consecutive dialysis sessions (first three of each month over a 6-month period) and various definitions of IDH were recorded. Global cognitive function (GCF) was assessed using the Mini-Mental State Examination (MMSE) and parameters of structural integrity of the CNS were obtained using volume morphometry magnetic resonance imaging analysis [grey matter (GM), white matter (WM) and hippocampus).

Results

A greater number of sessions with IDH were associated with less volume of WM (r = −0.359,P = 0.003) and hippocampus (r = −0.395, P = 0.001) independent of cardiovascular risk factors according to multivariable linear regression models (β = −0.198, P = 0.046 for WM; β = −0.253, P = 0.017 for hippocampus). The GCF by the MMSE was 27.3 ± 7.3.1 and was associated with WM volume (β = 0.403, P = 0.001) independent of GM and hippocampus volume. Symptomatic IDH was associated with GCF (r = −0.420, P < 0.001) in adjusted analysis (β = −0.339, P = 0.008).

Conclusions

Even when asymptomatic, IDH is associated with a lower WM and hippocampus volume and reduced GCF in patients undergoing HD, thus suggesting greater vulnerability of the brain to the haemodynamic stress that may be generated by a dialysis session.
Deep Extreme Learning Machine-Based Optical Character Recognition System for Nastalique Urdu-Like Script Languages
Authors: Rizvi Syed Saqib Raza , Khan Muhammad Adnan , Abbas Sagheer , Asadullah Muhammad , Anwer Nida , Fatima Areej
Published: March 2020

Optical character recognition systems convert printed or handwritten scripts into digital text formats like ASCII or UNICODE. Urdu-like script languages like Urdu, Punjabi and Sindhi are widely spoken languages of the world, especially in Asia. An enormous amount of printed and handwritten text of such languages exist, which needs to be converted into computer-understandable formats for knowledge extraction. In this study, extreme learning machine’s (ELM’s) most recently proposed variant called deep extreme learning machine (DELM)-based optical character recognition (OCR) system is proposed to enhance Urdu-like script language’s character recognition rate. The proposed DELM-based character recognition model is optimizing the OCR process by reducing the overhead of Pre-processing, Segmentation and Feature Extraction Layer. The proposed system evaluations accomplished 98.75% training accuracy with 1.492 × 10−3 RMSE and 98.12% testing accuracy with 1.587 × 10−3 RMSE, with six DELM hidden layers. The results show that the proposed system has attained the foremost recognition rate as compared to any previously proposed Urdu-like script language OCR system. This technique is applicable for machine-printed text and fractionally useful for handwritten text as well. This study will aid in the advancement of more accurate Urdu-like script OCR’s software systems in the future.
Review-Based Recommender Systems: A Proposed Rating Prediction Scheme Using Word Embedding Representation of Reviews
Authors: Hasanzadeh S , Fakhrahmad S M , Taheri M
Published: March 2020

Recommender systems nowadays play an important role in providing helpful information for users, especially in ecommerce applications. Many of the proposed models use rating histories of the users in order to predict unknown ratings. Recently, users’ reviews as a valuable source of knowledge have attracted the attention of researchers in this field and a new category denoted as review-based recommender systems has emerged. In this study, we make use of the information included in user reviews as well as available rating scores to develop a review-based rating prediction system. The proposed scheme attempts to handle the uncertainty problem of the rating histories, by fuzzifying the given ratings. Another advantage of the proposed system is the use of a word embedding representation model for textual reviews, instead of using traditional models such as binary bag of words and TFIDF 1 vector space. It also makes use of the helpfulness voting scores, in order to prune data and achieve better results. The effectiveness of the rating prediction scheme as well as the final recommender system was evaluated against the Amazon dataset. Experimental results revealed that the proposed recommender system outperforms its counterparts and can be used as a suitable tool in ecommerce environments.
Does a cannibal feeding strategy impart differential metabolic performance in young burbot (Lota lota maculosa)?
Authors: Frazier Amanda J , Jensen Nathan R , Young Shawn P , Todgham Anne E
Published: March 2020

The practice of mitigating cannibalism in aquaculture is an important focus for hatcheries seeking to maximize yield and has been maintained in hatcheries focusing on wild stock restoration. We hypothesize, however, that a cannibal feeding strategy may confer performance advantages over a non-cannibal feeding strategy and that perhaps cannibal size grading may not be optimal for hatcheries focusing on conservation goals. This study examined metabolic performance differences between cannibal and non-cannibal burbot, Lota lota maculosa, at the Kootenai Tribe of Idaho Twin Rivers Hatchery in Moyie Springs, ID, USA. After habitat alteration led to functional extinction of burbot in the region, the Twin Rivers Hatchery has played a leading role in the reestablishment of burbot in the Kootenai River, ID, and British Columbia. We examined morphometric data (weight, length and condition factor), whole animal resting metabolic rate and the enzyme activity of lactate dehydrogenase, citrate synthase and 3-hydroxyacyl-CoA dehydrogenase to describe the baseline metabolic performance of cannibal and non-cannibal burbot. Taken together, our results demonstrated significant differences in the metabolic strategies of cannibal vs. non-cannibal burbot, where cannibals relied more heavily on carbohydrate metabolism and non-cannibals relied more heavily on glycolytic and lipid metabolism. This study demonstrates the need to reevaluate the traditional practice of removing cannibal fish in conservation hatcheries, as it may not be the ideal strategy of raising the most robust individuals for release. When natural habitat conditions cannot be restored due to permanent habitat alteration, prioritizing release of higher performing individuals could help achieve conservation goals.
Homotopy analysis of the Lippmann–Schwinger equation for seismic wavefield modelling in strongly scattering media
Authors: Jakobsen Morten , Huang Xingguo , Wu Ru-Shan
Published: March 2020

We present an application of the homotopy analysis method for solving the integral equations of the Lippmann–Schwinger type, which occurs frequently in acoustic and seismic scattering theory. In this method, a series solution is created which is guaranteed to converge independent of the scattering potential. This series solution differs from the conventional Born series because it contains two auxiliary parameters ϵ and h and an operator H that can be selected freely in order to control the convergence properties of the scattering series. The ϵ-parameter which controls the degree of dissipation in the reference medium (that makes the wavefield updates localized in space) is known from the so-called convergent Born series theory; but its use in conjunction with the homotopy analysis method represents a novel feature of this work. By using H = I (where I is the identity operator) and varying the convergence control parameters h and ϵ, we obtain a family of scattering series which reduces to the conventional Born series when h = −1 and ϵ = 0. By using H = γ where γ is a particular pre-conditioner and varying the convergence control parameters h and ϵ, we obtain another family of scattering series which reduces to the so-called convergent Born series when h = −1 and ϵ ≥ ϵc where ϵc is a critical dissipation parameter depending on the largest value of the scattering potential. This means that we have developed a kind of unified scattering series theory that includes the conventional and convergent Born series as special cases. By performing a series of 12 numerical experiments with a strongly scattering medium, we illustrate the effects of varying the (ϵ, h, H)-parameters on the convergence properties of the new homotopy scattering series. By using (ϵ, h, H) = (0.5, −0.8, I) we obtain a new scattering series that converges significantly faster than the convergent Born series. The use of a non-zero dissipation parameter ϵ seems to improve on the convergence properties of any scattering series, but one can now relax on the requirement ϵ ≥ ϵc from the convergent Born series theory, provided that a suitable value of the convergence control parameter h and operator H is used.
Conditions for shared decision making in the care of transgender youth in Canada
Authors: Clark Beth A , Virani Alice , Marshall Sheila K , Saewyc Elizabeth M
Published: March 2020

Information is lacking on the role shared decision making plays in the care of transgender (trans) youth. This qualitative, descriptive study explored how trans youth, parents and health care providers engaged or did not engage in shared decision-making practices around hormone therapy initiation and what conditions supported shared decision-making approaches in clinical practice. Semi-structured interviews were conducted with 47 participants in British Columbia, Canada, and analyzed using a constructivist grounded theory approach. While formal shared decision-making models were not used in practice, many participants described elements of such approaches when asked about their health care decision-making processes. Others described health care interactions that were not conducive to a shared decision-making approach. The key finding that emerged through this analysis was a set of five conditions for supporting shared decision making when making decisions surrounding initiation of hormone therapy with trans youth. Both supportive relationships and open communication were necessary among participants to support shared decision making. All parties needed to agree regarding what decisions were to be made and what role each person would play in the process. Finally, adequate time was needed for decision-making processes to unfold. When stakeholders meet these five conditions, a gender-affirming and culturally safer shared decision-making approach may be used to support decision making about gender-affirming care. Implications for clinical practice and future research are discussed.
Understanding policy change for obesity prevention: learning from sugar-sweetened beverages taxes in Mexico and Chile
Authors: Fuster Melissa , Burrowes Sahai , Cuadrado Cristóbal , Velasco Bernal Anabel , Lewis Sarah , McCarthy Ben , Shen Gordon C
Published: March 2020

This article examines the policy change process that resulted in the current sugar-sweetened beverages taxes in Mexico and Chile, using the Kaleidoscope Model for Policy Change, a framework developed for nutrition and food policy change analysis. We used a qualitative study design, including 24 key informant (KI) interviews (16 researchers, 5 civil society representatives and 3 food/beverage industry representatives), encompassing global and in-country perspectives. The analysis shows concurrence with the Kaleidoscope Model, highlighting commonalities in the policy change process. These included the importance of focusing events and coalitions for agenda-setting. Both top-down executive leadership and bottom-up pressure from civil society coalitions were important for the policy adoption as were flexible framing of the tax, and taking advantage of windows of opportunity. In both countries, the tax resulted from national, revenue-seeking fiscal reforms and in sub-optimal tax rates, as a result of the industry influence. KIs also discussed emerging evaluation results, highlighting differences in interpretation concerning the magnitude of change from the tax, and shared potential modifications to the current policies. This analysis contributes to a greater understanding of the policy change process focused on obesity prevention, using an innovative theoretical framework developed specifically for food and nutrition policy.
Accountability, denial and the future-proofing of British torture
Authors: Blakeley Ruth , Raphael Sam
Published: March 2020

When powerful liberal democratic states are found to be complicit in extreme violations of human rights, how do they respond and why do they respond as they do? Drawing on the example of the United Kingdom's complicity in torture since 9/11, this article demonstrates how reluctant the UK has been to permit a full reckoning with its torturous past. We demonstrate that successive UK governments engaged in various forms of denial, obfuscation and attempts to obstruct investigation and avoid accountability. The net effect of their responses has been to deny the victims redress, through adequate judicial processes, and to deny the public adequate state accountability. These responses are not simply aimed at shielding from prosecution the perpetrators and those who have oversight of them, nor preventing political embarrassment. The various forms of denial and obstruction are also designed to ensure that collusion can continue uninterrupted. A core concern of intelligence officials and ministers has been to prevent any process that would lead to a comprehensive prohibition on involvement in operations where torture and cruel, inhuman and degrading treatment are a real possibility. The door remains wide open, and deliberately so, for British involvement in torture.
Development of an Interdisciplinary Telehealth Model of Provider Training and Comprehensive Care for Hepatitis C and Opioid Use Disorder in a High-Burden Region
Authors: Sherbuk Jacqueline E , Knick Terry Kemp , Canan Chelsea , Ross Patrice , Helbert Bailey , Cantrell Eleanor Sue , Cantrell Charlene Joie , Stallings Rachel , Barron Nicole , Jordan Diana , McManus Kathleen A , Dillingham Rebecca
Published: March 2020

Background

Hepatitis C virus (HCV) and the opioid epidemic disproportionately affect the Appalachian region. Geographic and financial barriers prevent access to specialty care. Interventions are needed to address the HCV-opioid syndemic in this region.

Methods

We developed an innovative, collaborative telehealth model in Southwest Virginia featuring bidirectional referrals from and to comprehensive harm reduction (CHR) programs and office-based opioid therapy (OBOT), as well as workforce development through local provider training in HCV management. We aimed to (1) describe the implementation process of provider training and (2) assess the effectiveness of the telehealth model by monitoring patient outcomes in the first year.

Results

The provider training model moved from a graduated autonomy model with direct specialist supervision to a 1-day workshop with parallel tracks for providers and support staff followed by monthly case conferences. Forty-four providers and support staff attended training. Eight providers have begun treating independently. For the telehealth component, 123 people were referred, with 62% referred from partner OBOT or CHR sites; 103 (84%) attended a visit, 93 (76%) completed the treatment course, and 61 (50%) have achieved sustained virologic response. Rates of sustained virologic response did not differ by receipt of treatment for opioid use disorder.

Conclusions

Providers demonstrated a preference for an in-person training workshop, though further investigation is needed to determine why only a minority of those trained have begun treating HCV independently. The interdisciplinary nature of this program led to efficient treatment of hepatitis C in a real-world population with a majority of patients referred from OBOTs and CHR programs.
Long-Term Survival, Health, Social Functioning, and Education in Patients With an Enterovirus Central Nervous System Infection, Denmark, 1997–2016
Authors: Omland Lars H , Holm-Hansen Charlotte , Lebech Anne-Mette , Dessau Ram B , Bodilsen Jacob , Andersen Nanna S , Roed Casper , Christiansen Claus B , Ellermann-Eriksen Svend , Midgley Sofie , Nielsen Lene , Benfield Thomas , Hansen Ann-Brit E , Andersen Christian Ø , Rothman Kenneth J , Sørensen Henrik T , Fischer Thea K , Obel Niels
Published: March 2020

Background

The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.

Methods

We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997–2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.

Results

Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95% confidence interval [CI], 4.17–24.1), but thereafter mortality was not higher (MMR = 0.94; 95% CI, 0.47–1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.

Conclusions

Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.
A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection
Authors: Alkema Manon , Reuling Isaie J , de Jong Gerdie M , Lanke Kjerstin , Coffeng Luc E , van Gemert Geert-Jan , van de Vegte-Bolmer Marga , de Mast Quirijn , van Crevel Reinout , Ivinson Karen , Ockenhouse Christian F , McCarthy James S , Sauerwein Robert , Collins Katharine A , Bousema Teun
Published: March 2020

Background

For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and develop models for early-clinical evaluation of transmission-blocking interventions.

Methods

In a randomized open-label trial, 24 participants were infected by bites from Plasmodium falciparum 3D7-infected mosquitoes (mosquito bite [MB]; n = 12) or by induced blood-stage malaria (IBSM) with the same parasite line (n = 12). After subcurative piperaquine treatment, asexual parasite and gametocytes kinetics were assessed, and mosquito feeding experiments were performed.

Results

Study procedures were well tolerated. The median peak gametocyte density was 1304/mL (interquartile range, 308–1607/mL) after IBSM, compared with 14/mL (10–64/mL) after MB inoculation (P < .001), despite similar peak asexual parasite densities (P = .48). Peak gametocyte density was correlated with preceding pfap2-g transcripts, indicative of gametocyte commitment (ρ = 0.62; P = .002). Direct feeding assays resulted in mosquito infections from 9 of 12 participants after IBSM versus 0 of 12 after MB inoculation (P < .001).

Conclusions

We observed a striking effect of inoculation method on gametocyte production, suggesting higher gametocyte commitment after IBSM. Our direct comparison of MB and IBSM establishes the controlled human malaria infection transmission model, using intravenous administration of P. falciparum–infected erythrocytes as a model for early-clinical evaluation of interventions that aim to interrupt malaria transmission.

Clinical Trial Registration

NCT03454048
A Rule of Thumb for Hand Burns: Categorization and Mapping of Proportional Surface Area Involvement
Authors: Dargan Dallan , Adjei Bismark , Shokrollahi Kayvan
Published: March 2020

Hand burns are common and often complex injuries, requiring referral to specialist centers. The patient’s thumbprint is a rapid means of accurately assessing hand burn surface area. This study aimed to establish categories and evaluate sites of hand burn surface area in order to facilitate comparison of hand burns. Sixteen burns involving the hand and wrist among 14 patients referred to a burns center were retrospectively categorized by burn mechanism, burn thickness, and hand burn surface area. The burn surface area in the clinical record was compared with that calculated by the thumbprint method and the rule of thumb diagram. Burn surface area in the clinical record was either “1%” or “<1%” in 9 of 16 cases. In contrast, the surface area was <1 thumbprint (T) in six burns, two were between 1 and 5T, three were 5 to 10T, two were 10 to 20T, two were 20 to 50T, and one was greater than 50T. The median thumbprint burn surface area was 1.5T (range 0.20–80T), which corresponds to 0.05% TBSA. The hand areas with the highest burn frequency per unit area were the dorsum of the hand and dorsum of the index finger, with relative sparing of the palm and palmar surface of the digits. Hand burns surface area varies widely, and thumbprint evaluation with categories and mapping allows finer distinction between the surface area proportions and specific sites involved, even in a small series of hand burns.
Releasing Burn-Induced Compartment Syndrome by Enzymatic Escharotomy-Debridement: A Case Study
Authors: Mataro Ilaria , Lanza Anna , Di Franco Sveva , Di Franco Livia , Sangiuolo Mariella , Notaro Maria , d’Alessio Roberto , Villani Romolo
Published: March 2020

Burn-induced compartment syndrome represents a serious and acute condition in deep circumferential burns of the extremities which, if left untreated, can cause severe complications. The surgical escharotomy that releases the high subdermal pressure is the therapeutic treatment of choice for burn-induced compartment syndrome. Guidelines for escharotomy indications and timing include pressure greater than 30 mm Hg and 6 Ps (Pain, Pallor, Paresthesia, Paralysis, Pulseless, and Poikilothermia). Nevertheless, despite the need for an early as possible pressure release, escharotomy is often delayed when a capable surgeon is not available, or if the indication is not completely clear to justify potential risks associated with surgical escharotomy. Early treatment of circumferential burns of the extremities with a Bromelain-based enzymatic agent NexoBrid® may represent a less traumatic and invasive procedure to reduce intra-compartmental pressure, replacing surgical escharotomy. This case study of 23 patients describes the variation of compartmental pressure in patients with circumferential burns of the extremities treated with NexoBrid® enzymatic escharotomy-debridement. All the patients were treated with NexoBrid® within 2 to 22 hours post-injury in our Burn Intensive Care Center. The excessive pressure recorded before treatment returned to normal below 30 mm Hg and an approximately 60% reduction of the compartmental pressure was observed in most cases within 1 hour from NXB application. On NexoBrid® removal after 4 hours complete debridement-escharotomy of the burns was achieved. Enzymatic escharotomy-debridement appears to be a useful and safe method to reduce postburn compartmental pressure. Additional randomized, well-controlled powered studies are needed to further support these results.
Duped or duplicitous?
Authors: Catterson Lynn
Published: March 2020

Deriving from material in the state and city archives of Florence relating to the Florentine dealer Stefano Bardini as well as material in the Berlin Zentralarchiv, this paper presents a case-study that illustrates the ways in which Bardini & Co. wilfully contaminated the art-historical canon. The bas-relief of the so-called Madonna della Rosa, often attributed to Donatello, exists in at least five versions, but four have a provenance dating no earlier than the nineteenth or very early twentieth century. This composition was first published by Wilhelm von Bode in 1892 with an attribution to Donatello. Thereafter, the literature was amended to accommodate art-market tastes. Archival evidence indicates that Bardini & Co. used photographs and plaster casts to produce at least some of the versions. The various reliefs of the Madonna della Rosa are but one example of the dubious objects put into circulation by Bardini, and then written into the scholarly literature by Bode. These objects raise questions about their relationship and the real agency of Bode.
Near-infrared variability in dusty white dwarfs: tracing the accretion of planetary material
Authors: Rogers Laura K , Xu (许偲艺) Siyi , Bonsor Amy , Hodgkin Simon , Su Kate Y L , von Hippel Ted , Jura Michael
Published: March 2020

The inwards scattering of planetesimals towards white dwarfs is expected to be a stochastic process with variability on human time-scales. The planetesimals tidally disrupt at the Roche radius, producing dusty debris detectable as excess infrared emission. When sufficiently close to the white dwarf, this debris sublimates and accretes on to the white dwarf and pollutes its atmosphere. Studying this infrared emission around polluted white dwarfs can reveal how this planetary material arrives in their atmospheres. We report a near-infrared monitoring campaign of 34 white dwarfs with infrared excesses with the aim to search for variability in the dust emission. Time series photometry of these white dwarfs from the United Kingdom Infrared Telescope (Wide Field Camera) in the J-, H-, and K-bands was obtained over baselines of up to 3 yr. We find no statistically significant variation in the dust emission in all three near-infrared bands. Specifically, we can rule out variability at ∼1.3 per cent for the 13 white dwarfs brighter than 16th mag in K-band, and at ∼10 per cent for the 32 white dwarfs brighter than 18th mag over time-scales of 3 yr. Although to date two white dwarfs, SDSS J095904.69−020047.6 and WD 1226+110, have shown K-band variability, in our sample we see no evidence of new K-band variability at these levels. One interpretation is that the tidal disruption events that lead to large variabilities are rare occur on short time-scales, and after a few years the white dwarfs return to being stable in the near-infrared.
Photometric and kinematic study of the three intermediate age open clusters NGC 381, NGC 2360, and Berkeley 68
Authors: Maurya Jayanand , Joshi Y C
Published: March 2020

We present UBVRcIc photometric study of three intermediate age open star clusters NGC 381, NGC 2360, and Berkeley 68 (Be 68). We examine the cluster membership of stars using recently released Gaia DR2 proper motions and obtain a total of 116, 332, and 264 member stars in these three clusters. The mean reddening of E(B − V) = 0.36 ± 0.04, 0.08 ± 0.03, and 0.52 ± 0.04 mag is found in the direction of these clusters where we observe an anomalous reddening towards NGC 381. We fitted the solar metallicity isochrones to determine age and distance of the clusters which are found to be log(Age) = 8.65 ± 0.05, 8.95 ± 0.05, and 9.25 ± 0.05 yr with the respective distance of 957 ± 152, 982 ± 132, and 2554 ± 387 pc for the clusters NGC 381, NGC 2360, and Be 68. A two-stage power law in the mass function (MF) slope is observed in the cluster NGC 381, however, we observe only a single MF slope in the clusters NGC 2360 and Be68. To study a possible spatial variation in the slope of MF, we estimate slopes separately in the inner and the outer regions of these clusters and notice a steeper slope in outer region. The dynamic study of these clusters reveals deficiency of low-mass stars in their inner regions suggesting the mass segregation process in all these clusters. The relaxation times of 48.5, 78.9, and 87.6 Myr are obtained for the clusters NGC 381, NGC 2360, and Be 68, respectively, which are well below to their respective ages. This suggests that all the clusters are dynamically relaxed.
Failed prominence eruptions near 24 cycle maximum
Authors: Filippov B
Published: March 2020

We analyse 16 failed filament eruptions observed near 24 solar cycle maximum from 2013 May to 2014 July. No significant rotation of filament spines is observed during the ascent in all studied failed eruptions, which does not support kink-instability mechanism of triggering the eruptions. We calculate potential magnetic field distributions in the corona above the initial locations of the filaments to study their height dependence. In seven events, the vertical profiles of the decay index n are monotonic. The other nine events occur in the regions with the switchback or saddle-like n-profiles. The direction of the horizontal field near the saddle bottom is turned through more than 100° relative its direction at the initial filament position, which reveals the quadrupolar magnetic configuration with null points in these regions. The eruptive filaments stop above the null points where the total Lorentz force is directed upward. The most reasonable force that can terminate filament ascending and balance the Lorentz force seems the gravity.
The fates of the circumgalactic medium in the FIRE simulations
Authors: Hafen Zachary , Faucher-Giguère Claude-André , Anglés-Alcázar Daniel , Stern Jonathan , Kereš Dušan , Esmerian Clarke , Wetzel Andrew , El-Badry Kareem , Chan T K , Murray Norman
Published: March 2020

We analyse the different fates of the circumgalactic medium (CGM) in FIRE-2 cosmological simulations, focusing on the redshifts z = 0.25 and 2 representative of recent surveys. Our analysis includes 21 zoom-in simulations covering the halo mass range $M_{\rm h}(z=0) \sim 10^{10} \!-\! 10^{12} \rm {\,M}_\odot$. We analyse both where the gas ends up after first leaving the CGM (its ‘proximate’ fate) and its location at z = 0 (its ‘ultimate’ fate). Of the CGM at z = 2, about half is found in the ISM or stars of the central galaxy by z = 0 in Mh(z = 2) ∼ 5 × 1011 M⊙ haloes, but most of the CGM in lower mass haloes ends up in the intergalactic medium (IGM). This is so even though most of the CGM in Mh(z = 2) ∼ 5 × 1010 M⊙ haloes first accretes on to the central galaxy before being ejected into the IGM. On the other hand, most of the CGM mass at z = 0.25 remains in the CGM by z = 0 at all halo masses analysed. Of the CGM gas that subsequently accretes on to the central galaxy in the progenitors of Mh(z = 0) ∼ 1012 M⊙ haloes, most of it is cool (T ∼ 104 K) at z = 2 but hot (∼Tvir) at z ∼ 0.25, consistent with the expected transition from cold mode to hot mode accretion. Despite the transition in accretion mode, at both z = 0.25 and $2 \, {\gtrsim} 80{{\ \rm per\ cent}}$ of the cool gas in $M_{\rm h} \gtrsim 10^{11} \rm {M}_\odot$ haloes will accrete on to a galaxy. We find that the metallicity of CGM gas is typically a poor predictor of both its proximate and ultimate fates. This is because there is in general little correlation between the origin of CGM gas and its fate owing to substantial mixing while in the CGM.