bluuebunny/crossref_metadata_2025 huggingface dataset:
Segregation in Bimodal Contact/Combined Load: Tilting-Flume Study
Authors:   Dept. Civil Engineering, Czech Technical University in Prague, Thákurova 7, 166 29 Prague 6, Czech Republic, Matoušek Václav , Krupička Jan ,   Dept. Civil Engineering, Czech Technical University in Prague, Thákurova 7, 166 29 Prague 6, Czech Republic, Picek Tomáš ,   Dept. Civil Engineering, Czech Technical University in Prague, Thákurova 7, 166 29 Prague 6, Czech Republic, Svoboda Lukáš ,   Dept. Civil Engineering, Czech Technical University in Prague, Thákurova 7, 166 29 Prague 6, Czech Republic
Published: October 2023

In this contribution, the effects of solids segregation on intense transport of solids and bed friction in a laboratory flume are evaluated by comparing bimodal solids flows with the corresponding flows of unimodal solids. The comparison is carried out for two types of solids transport: contact-load transport and combined-load transport. Experiments with intense transport of bimodal solids mixtures composed of two solids fractions that differ primarily in particle size showed a process of vertical sorting, resulting in partial segregation of the fractions in a flume. The segregation affected a layered structure of flow above the plane surface of an eroded bed. Lightweight solids fractions of different colors were used in the experiments to enable clear visual observation of the segregation. Measurements of integral quantities of steady, uniform solid-liquid flow were used to quantify solids transport parameters and bed friction parameters. The observed segregation patterns differ for the two types of solids transport and so differ their effects on solids discharge and bed friction coefficient in flows of the two bimodal mixtures.
An Investigation of the Effects of Manufacturing Parameters On Properties of Binderless Boards Produced from Abura (Mitragyna Ciliata) Sawdust
Authors:   University of Lagos Akoka, J. I. Orisaleye , A. A. Ogundare ,   University of Lagos Akoka, Y. O. Abiodun ,   University of Lagos Akoka, M. O. Oyekeye ,   University of Lagos Akoka, O. A. Adefuye ,   Lagos State University, S. J. Ojolo ,   University of Lagos Akoka, O. E. Owoeye ,   University of Lagos Akoka
Published: October 2023

The production of particleboards without the use of synthetic binders is desirable to prevent environmental problems. This study has produced experimental binderless boards from untreated sawdust from Abura wood using a laboratory press. Response Surface Methodology using Box-Behnken experimental design was utilized to investigate the influenceof pressing variables (pressure, pressing temperature and pressing time). Density of the bioboards produced wasbetween 523.69 and 738 kg/m3which was comparable tomedium density fibreboards. The maximum values for Internal Bonding Strength (IB), Modulus of Rupture (MOR)andModulus of Elasticity (MOE) were 0.049 MPa,1.1 MPaand100.4 MPa, respectively. It was shown that, for the range of factors studied, pressure and the pressing temperature were the more significant factors in determining the density, MOE and IB. This study showed that the sawdust can potentially be used for the manufactureof binderless boards.
Generative Design of A 6-Axis Quadcopter Drone for Weight Optimization
Authors:   Universiti Teknikal Malaysia Melaka, Md Ghazaly Mariam , Jun Kueh Tze ,   Universiti Teknikal Malaysia Melaka
Published: October 2023

Unmanned aerial vehicles (UAVs), known as drones, can be remotely operated using embedded technology and software-controlled flight plans. A six-axis drone's main problem is that its significant weight limits how much it can be used. As a result, the flexibility and endurance of the drone's design are necessary for excellent performance during altitude displacement. In order to create a body frame for the quadcopter, the project intends to solve the weight optimization problem via generative design. The three main steps of the optimization attempts utilizing generative design procedures are (a) abstraction, (b) initialization, and (c) interpretation. These are accomplished by employing the five generative design processes. The stress analysis and the generative design process were used to confirm that the generative design technique will help reduce the drone's weight. The drone using three (3) generative designs, was set to a total weight of less than 1kg. The results show that Generative Design 2 shows good optimization as follows, (a)50.00% of parts of assembly optimized from eight parts to four parts, (b) 54.09% of the weight of the body frame optimized from 1.1565kg to 0.531kg, (c) 36.17% of the height of the body frame optimized from 94mm to 60mm, (d) 45.44% of stress analysis increased from 3.457MPa to 5.028MPa, (e) 83.00% reduction of displacement elongation from 3.918mm to 0.666mm and (f) 61.25% of production time optimized from 40 hours to 15.5 hours.
Валидация разработанной методики пептидного картирования для подтверждения подлинности инсулина глулизина
Authors: Герасимова Т. , Киселева А. , Бадмаева Ц. , Гусаров Д. , Степанюк И. , Лосева Т. , Тарасова Т.
Published: October 2023

Для подтверждения подлинности субстанции инсулина глулизина, получаемой по собственной технологии в ООО «ГЕРОФАРМ», разработана и валидирована аналитическая методика пептидного картирования. Метод включает в себя этап энзиматического расщепления белка до образования пептидных фрагментов с последующим разделением и идентификацией этих фрагментов в воспроизводимых условиях методом ОФ ВЭЖХ. Валидацию разработанной методики проводили по всем валидационным требованиям, установленным ГФ РФ: специфичность, прецизионность (сходимость и воспроизводимость) и устойчивость. Показано, что данная методика соответствует установленным критериям приемлемости и обеспечивает достоверные результаты определения подлинности инсулина глулизина.
SOFRIMENTO MENTAL DE MULHERES EM ISOLAMENTO SOCIAL DURANTE A PANDEMIA DA COVID-19
Authors: Raquel Lima de Pontes Amélia , de Almeida Costa Patrício , Oliveira de Araújo Tainá , Figueirêdo da Silva Pascoal Francilene , Dantas Farias de Andrade Luciana , Alves de Medeiros Leano Heloisy
Published: October 2023

Objetivo: Analisar a frequência e características relacionadas ao possível sofrimento mental das mulheres em isolamento social durante a pandemia de covid-19. Metodologia: Estudo analítico, transversal, com abordagem quantitativa, realizado com 138 mulheres em diferentes regiões do estado da Paraíba. Os dados foram coletados por meio de questionário virtual entre janeiro e fevereiro de 2021, utilizando-se da técnica metodológica Bola de Neve Virtual. Sendo a análise subsidiada com o suporte da estatística descritiva e analítica por meio do software SPSS versão 20.0.  Resultados: foi observado entre as participantes do estudo, que 51,4 % (71) das mulheres apresentaram escore compatível para o possível sofrimento mental. Quando relacionado com as variáveis sociodemográficas, econômicas, de hábitos de vida e de convivência no isolamento social, evidenciou-se que apenas a variável “está em confinamento com mais alguém” mostrou uma relação estatisticamente com o possível sofrimento mental entre as participantes. Conclusões: A pandemia da Covid-19 e consequentemente o isolamento social tem provocado sofrimento mental entre as mulheres, especialmente no que diz respeito ao viver confinado com outra pessoa. Logo, recomenda-se fortalecer a atenção integral à saúde da mulher, com ênfase ações voltadas para a saúde mental durante o período pandemia e pós-pandemia. Também, faz-se necessário refletir sobre aspectos da responsabilização imposta pela sociedade para as mulheres, assim como, da sobrecarga e desigualdade na divisão de tarefas no ambiente doméstico e laboral.
Technological recommendations for improvement of functional coatings by ultrasound
Authors:   Moscow automobile and road construction state technical university (MADI), Nigmetzyanov R.I. , Sundukov S.K. ,   Moscow automobile and road construction state technical university (MADI), Sukhov A.V. ,   Moscow automobile and road construction state technical university (MADI), Fatyukhin D. S. ,   Moscow automobile and road construction state technical university (MADI), Lyovushkina N.V. ,   Moscow automobile and road construction state technical university (MADI)
Published: October 2023

The possibilities of using the ultrasonic technologies to improve the operational properties of functional coatings are considered. Technological recommendations for the use of ultrasonic technologies at various stages of coating deposition are proposed.
On the applied value of traditional Chinese aesthetics in modern illustration design
Authors: Xu Jing
Published: October 2023

The purpose of this article is to study the applied value of traditional Chinese aesthetics in modern illustration design, as well as to identify the features of combining traditional and modern aesthetic principles in creating illustrations.
Oracles of Ancient Egypt before the New Kingdom (c. 3000–1550 BC): a rethinking experience based on Ancient Egyptian Literature
Authors: Lei Li
Published: October 2023

Oracles, a religious practice, were prevalent in early human civilizations. However, it was not until the New Kingdom period, over 1,500 years after the inception of ancient Egyptian civilization, that direct records of oracle rituals came to light. The well-developed and institutionalized nature of oracle rituals during the New Kingdom era has ignited scholarly discussions concerning the origins of ancient Egyptian oracles. Whereas literary sources predating the New Kingdom may offer glimpses into certain aspects of oracle practices, they cannot serve as direct evidence of their existence and should be approached with a critical mindset.
"The Legal Basis for the Exercise of Jurisdiction by the International Criminal Court and the Preparatory Work of the Rome Statute (I)," Journal of International Relations and Comparative Culture, Vol. 16, No. 2 (March 2018), pp. 67-74.
Authors: Kitano Yoshiaki
Published: October 2023

This paper aims to discuss the legal basis for the exercise of jurisdiction by the International Criminal Court while viewing the topic as one of the issues demonstrating the current status of general international law concerning the creation of obligations for non-party states. The table of contents included in this part 1 is as follows: Chapter 1 Introduction (Section 1 Exercise of Jurisdiction by the ICC and Consent of States: Provisions of the Statute / Section 2 Rules of the Law of Treaties on Creation of Obligations for Non-Party States: Provisional Examination).
A Neuro-Mimetic Realization of the Common Model of Cognition via Hebbian Learning and Free Energy Minimization
Authors: Ororbia Alexander G. , Kelly M. Alex
Published: October 2023

Over the last few years, large neural generative models, capable of synthesizing semantically rich passages of text or producing complex images, have recently emerged as a popular representation of what has come to be known as ``generative artificial intelligence'' (generative AI). Beyond opening the door to new opportunities as well as challenges for the domain of statistical machine learning, the rising popularity of generative AI brings with it interesting questions for Cognitive Science, which seeks to discover the nature of the processes that underpin minds and brains as well as to understand how such functionality might be acquired and instantianted in biological (or artificial) substrate. With this goal in mind, we argue that a promising research program lies in the crafting of cognitive architectures, a long-standing tradition of the field, cast fundamentally in terms of neuro-mimetic generative building blocks. Concretely, we discuss the COGnitive Neural GENerative system, such an architecture that casts the Common Model of Cognition in terms of Hebbian adaptation operating in service of optimizing a variational free energy functional.
Effects of socioeconomic status on left-right voting intentions: the role of economic ideology, perceived threats, and national identity
Authors: Lois Giannis , Petkanopoulou Katerina , Garcia-Sanchez Efrain , Willis Guillermo B. , Rodriguez-Bailon Rosa
Published: October 2023

Existing evidence suggests that low socioeconomic status (SES) individuals vote for left-wing parties on economic grounds and right-wing parties on cultural grounds, while high SES individuals exhibit the opposite pattern. Although various psychological mechanisms may explain this pattern, it is still unclear whether these mechanisms mediate this relationship. In a preregistered study, we use data from 9 European countries (N = 8,750) to quantify and compare the mediating role of economic system justification, economic and symbolic threats, anti-immigrant attitudes, and national identification on the relationship between two dimensions of SES (education and subjective income) and left-right voting intentions. Anti-immigrant attitudes and immigration-specific threat best explained why low educated individuals vote for right-wing parties. In contrast, we observed a positive link between subjective income and right-wing voting, which was predominantly explained by endorsement of economic system-justifying beliefs. These findings showcase the disparity between income-related and education-related effects and highlight the heterogeneous psychological processes that underlie the relationship between SES and left-right voting intentions.
Artificial Intelligence in Medicine: The Influence of Medical Expertise and Perceived Causability on Medical AI Risk and Benefit Perception
Authors: Said Nadia , Schumacher Lea , Huff Markus
Published: October 2023

Artificial intelligence (AI) is increasingly used in medicine, making it one of the largest and fastest-growing fields in which AI is applied. While some AI-based applications are already outperforming experts regarding diagnostic accuracy, patients’ trust in AI is still comparatively low. Given the tremendous potential of medical AI applications, understanding what influences patients’ and doctors’ perceptions of medical AI is of utmost importance. To this end, we assessed for N = 750 participants (N = 684 laypeople and N = 66 medical experts) whether medical expertise and perceived causability, that is the transparency, efficiency and satisfaction with which the AI is perceived, are related to the perception of risks and benefits in three different medical AI scenarios. Benefit perception increased with higher perceived causability but was unrelated to medical expertise. On the other hand, risk perception increased with higher medical expertise and decreased with higher perceived causability. Therefore, when introducing and using medical AI applications in the treatment of patients, it is essential to sensitize both patients and medical experts to the different perceptions. Such measures can be an important prerequisite for increasing AI acceptance in medicine.
A Field Theory of Human Intelligence
Authors: Griswold Alan
Published: October 2023

The standard model of human intelligence is a brain-centric and brain-specific depiction of intelligence, and it enjoys nearly universal acceptance within the intelligence research community. Nonetheless, the standard model does face some serious challenges, including a lack of specificity and an inability to account for the Flynn effect (other than to assume that the Flynn effect must be a temporary aberration). What is being presented here is an alternative model of human intelligence, one that locates intelligence not within the human brain but instead within the growing amount of artificial structure contained within the human environment. Although this field theory approach to human intelligence runs counter to the widely accepted standard model, a field theory approach does offer several advantages. One, it eschews any extraordinary biological or evolutionary assumptions regarding the functioning of the human brain. Two, it provides a specific and observable description of the material structure of human intelligence. And three, it gives a straightforward and elegant explanation of the Flynn effect. For these reasons, a field theory of human intelligence merits serious consideration.
‘I’ve Just Seen a Face’: The Effects of Facial Appearance on Measures of Generalized Trust
Authors: Robbins Blaine G , Grigoryeva Maria
Published: October 2023

Research suggests various associations between generalized trust and a wide range of economic, political, and social dimensions. Despite its importance, there is considerable debate about how best to measure generalized trust. One recent solution operationalizes generalized trust as the average of trust ratings across a small set of trust domains and human faces. Here, we investigate whether heterogeneity in facial appearance affects the psychometric properties of these new instruments. In a survey experiment conducted with a sample of U.S. adults (n = 5,001), we randomly assigned respondents to one of five conditions that varied the features of human and AI-synthesized faces. Irrespective of the condition, respondents rated each face along four trust domains. We find that facial heterogeneity has negligible effects on the measurement validity and measurement equivalence of these new instruments. Small mean differences are observed for a subset of faces. These findings demonstrate the power of using faces to measure generalized trust, and the utility of using AI-synthesized faces in social science research more broadly.
Dementia Care Coordinators: A service evaluation into the successes and challenges of the Kent and Medway ICB Pilot Project
Authors: Abrams Ruth
Published: October 2023

Background: In July 2021, Kent and Medway ICB (UK) funded nine Dementia Care Coordinator (DCC) posts to improve care for people with dementia and their families. This as a pilot project where each DCC was assigned to a Primary Care Network (collection of GP practices covering 30,000 -50,000 people). Following the end of the pilot, DCCs were invited to participate in a focus group to explore successes and challenges. This report presents findings from the focus group. Methods: Nine DCCs were invited to engage in this study. Three DCCs provided informed consent and attended a 90 minute online focus group. Data were subsequently transcribed and analysed using thematic analysis which is a rigorous analytical approach to qualitative data. Findings: Findings indicate that, according to DCCs, the service appears to reduce anxiety and worry amongst people living with dementia and their carers across all points of the dementia journey. Knowing that a key point of contact is available to them means that when they notice a change in their wellbeing, they may feel more inclined to contact an impartial, non-clinical individual for signposting. In the meantime, DCCs weave webs of care around people living with dementia so to provide the best possible support. DCCs found it challenging at times to: (1) work with GPs; (2) to support people living with dementia whilst also living alone; (3) manage service user and carer expectations about their role and: (4) to manage their growing patient lists and workload. Conclusions: Overall, to ensure a sustainable service, key recommendations in need of further exploration include: (1) ensuring buy in from key stakeholders, specifically GPs; (2) facilitating staff support and training including clinical supervision/ observations, and: (3) ensuring the service is adequately staffed to protect staff workload and ensure sufficient capacity to enable delivery of high-quality care to service users.A larger scale evaluation is currently underway, due to be completed in October 2024 (see Abrams et al., 2023 for further details).
Material culture revealed from the antiquities obtained from the excavation of Gambhirwa Tola (Anuppur, M.P.)
Authors: Shrotriya Alok , Jain Jinendra Kumar , Chadhar Mohan Lal
Published: October 2023

Archaeological investigations of Darsagar Panchayat in Kotma tehsil area near Maikal mountain in Anuppur district of Madhya Pradesh and excavation at a site named Gambhirwa Tola was done by the authors. In the said archaeological expeditions, numerous antiquities have been found which are helpful in illuminating the ancient history of Anuppur region and connecting the lost links. There are several aspects included in the study of society. Generally, human society is represented in four areas – political, social, economic and religious. In archaeological exploration and excavation, material related to these four areas is broadly documented, analyzed and interpreted. In the detailed excavation, numerous antiquities have been found which reveal various aspects of human life of that time, on the basis of which an attempt has been made to reconstruct the past lifestyle of humans living in the area near Maikal mountain and its vicinity.
Abstract in Hindi Language:
मध्यप्रदेश के अनूपपुर जिले में मैकल पर्वत की समीपवर्ती कोतमा तहसील क्षेत्र में दारसागर पंचायत का पुरातात्विक अन्वेषण एवं गम्भीरवा टोला नामक स्थल उत्खनन लेखकों द्वारा किया गया। उक्त पुरातात्विक अनुसंधान में अनुपपुर क्षेत्र के  प्राचीन इतिहास को प्रभासित करने एवं विलुप्त कड़ियों को जोड़ने में सहायक बहुसंख्यक पुरावशेष प्राप्त हुए हैं। मानव समाज अपने परिवेश में विविध पक्षों को समाहित किए हुए होता है। आमतौर पर मानव समाज को चार क्षेत्रों या पहलुओं में निरूपित किया जाता है- राजनीतिक, सामाजिक,आर्थिक एवं  धार्मिक। पुरातात्विक अन्वेषण एवं उत्खनन में मौटे तौर पर इन्ही चार क्षेत्रों से संबंधित सामग्री को प्रलेखित, विश्लेषित एवं व्याख्यायित किया जाता है। विवेच्य उत्खनन में तत्कालीन मानव जीवन के विविध पक्षों को सामने लाने वाले बहुसंख्यक पुरावशेष प्राप्त हुए हैं जिनके आधार पर मैकल के समीपवर्ती क्षेत्र में निवासित मानव की भूतकालीन जीवन-पद्धति के पुनर्निर्माण का प्रयास  किया गया है।
 Keywords:  उत्खनन, पुरातत्व, मानव, भौतिक संस्कृति, पुरावशेष, मृद्‍भाण्ड, मृण्मूर्तियाँ, वलय-कूप
Transitional loss of consciousness as an interdisciplinary problem of diagnosis
Authors: Petrova N. N. , Semenova N. V.
Published: October 2023

The review is devoted to the classification, diagnosis and differential diagnosis of transient loss of consciousness. The pathophysiology of transient loss of consciousness is described. It is concluded that the criteria for the differential diagnosis of transient disorders of consciousness need further development and validation. The problem of paroxysmal disorders of consciousness is interdisciplinary in nature and requires the combined efforts of doctors of different specialties to develop a unified algorithm for clinical, laboratory and instrumental diagnostics, determine management tactics and correct patient routing.
In, Against, and Beyond the Ivory: Dreams of Belonging Otherwise through Wonder and Embodied Poetry
Authors: Cagulada Elaine , Esteban Jose Miguel
Published: October 2023

In this article, the authors navigate how equity, diversity, and inclusion (EDI) projects tether us to the neoliberal university in seductive and ultimately, limited ways. The topical triad of EDI, explored through the Canadian Congress of Humanities and Social Sciences’ “Igniting Change: Final Report and Recommendations,” holds important stories about how disability, race, and broadly speaking, normalcy, matter to academic institutions. How is disability storied within the neoliberal university? How are we called to belong within, and be members of, the university through the promise of progress? A poetic engagement creates space for wonder, simultaneously effacing stories that claim to know disability, race, and other forms of being-in-the-world codified as non-normal. As an expression of feeling as freedom, embodied poetry is a creative response to white-settler hegemonic interests that foreclose possibilities for meanings of disability and race; embodied poetry potentiates dreams of living otherwise within, against, and beyond the ivory.
Strategies for correction of physical and emotional states in adolescent girls with body weight disorders
Authors: Chekhovska L. , Martyn P. , Kovalenko O. , Kovtun О. , Kovalchuk D.
Published: October 2023

The article analyzes existing strategies of physical activity aimed at correcting the physical and emotional states in adolescents with body weight disorders. The aim of the study was to investigate the existing approaches to correcting the physical and emotional state in adolescent girls with body weight disorders. Methods. Theoretical analysis of special scientific and methodological literature and documentary materials, comparative analysis, and pedagogical methods were used. Research results. Based on a systematic analysis of specialized literature and documentary materials, the prevalence of body weight disorders among children and adolescents worldwide and in Ukraine was evaluated. Global trends in childhood and adolescent obesity were highlighted. Factors leading to weight disorders were characterized, including decreased physical activity, insufficient sleep, eating behavior disorders, and psychological status. An analysis of program documents aimed at increasing the level of physical activity was carried out, focusing on the implementation of effective strategies and programs for the physical activity of children and adolescents. The development of an effective motivation and incentive system for engaging in physical activity, coordination of multisectoral strategies to promote an active lifestyle, and the improvement of the quality of physical education in educational institutions at all levels were discussed. A systematic analysis of specialized literature allowed summarizing existing approaches to correction strategies for the physical and emotional well-being of adolescent girls with weight disorders. Conclusions. Based on the collected material, recommendations for increasing the involvement of children and adolescents in physical activity programs aimed at correcting the physical and emotional well-being of adolescent girls with weight disorders were summarized.
KLASİK TÜRK ŞİİRİ GAZELLERİNDE VEDA
Authors: ARI Ramazan
Published: October 2023

Hayatın içindeki klasik haliyle dahi duygusal ve estetik gerilimi ihtiva eden veda, şairlerin muhayyilesinde yeni boyutlar kazanarak estetik bir hüviyete bürünür. Klasik Türk şiirinde veda, gazeller itibariyle mercek altına alındığında, üç çeşidinden söz edilebilir: Kederi doğuran veda, mutluluğu getiren veda ve gayr-ı ihtiyari veda. Kederi doğuran vedada, veda edenle veda edilen arasındaki sevgi bağı, hasreti ve kederi doğurur. Bu tarz vedada ayrılık bir kopuştur. Sevgi bağıyla birbirine bağlı özne ve nesne istemsizce birbirinden ayrılır. Hasret, aradaki bağın duygu boyutunda devamıdır. Mutluluğu doğuran vedada ise veda eden ile veda edilen arasındaki olumsuz bağ, veda nesnesinden duyulan rahatsızlık, memnuniyetsizlik ya da birlikteliğin zorunlu bir beraberlik olması itibariyledir. Bu tür vedada ise ayrılık bir kurtuluştur. Getirdiği mutluluk buna bağlıdır. Gayr-ı ihtiyari yapılan vedada ise ayrılık, bir yitiriş, bir vazgeçiştir. İstemsizce, bazen gereklilikten bazen de zorunluluktan yapılır. Veda çeşitlerinin yanında klasik Türk şiiri şairleri, özellikle veda öznesi ve veda nesnesinin farklı kullanımlarıyla birçok kompozisyon oluşturarak kavramı zenginleştirmişlerdir. Veda biçimlerine de şiirlerinde yer veren şairler vedayı, yalnızca sevgili ile âşık arasında gerçekleşen klasik bir eylemin ötesine taşımışlardır. Bu çalışmada klasik Türk şiiri gazellerinde veda kavramı, veda türleri, veda eden/edilenler ve veda biçimleri itibariyle ele alınmak suretiyle incelenmiştir.
Disseminated Thymic Carcinoma: Case Report and Discussion on Problems of Treatment
Authors: Tumanova Kristina , Salim Nidal , Loyko Ilya , Stolbovoy Alexander , Tumanova Kristina , Prokofiev Igor
Published: October 2023

Thymic carcinoma (TC) is a rare epithelial malignancy often distinguished by significant local invasion and propensity for distant metastases. Representing approximately 20% of all thymic neoplasms, the primary therapeutic intervention for resectable tumors remains surgical resection. For those that are unresectable or metastatic, palliative platinum-based chemotherapy is standard. Despite these interventions, approximately 30% of these malignancies are already advanced upon initial presentation. The current 5-year survival rate for metastatic TC stands at approximately 38%, with a definitive optimal treatment regimen yet to be established. This case report delineates a comprehensive five-year clinical trajectory of a patient with advanced TC who exhibited resistance to systemic treatments but showed favorable response to stereotactic body radiation therapy (SBRT). Through this case, we underscore the potential of SBRT as a viable therapeutic alternative for select metastatic TC patients. In our case, SBRT exhibited reliable local tumor control in each treated site with minimal side effects. To better understand the possibility of treatment options for disseminated TC more cases should be collected.
FIERCE MEDICINES, FRAGILE SOCIALITIES
Authors: Mattes Dominik
Published: October 2023

Set in Tanga, a city on the Tanzanian Swahili coast, Dominik Mattes examines the implementation of antiretroviral HIV-treatment (ART) in the area, exploring the manifold infrastructural and social fragilities of treatment provision in public HIV clinics as well as patients’ multi-layered struggles of coming to terms with ART in their everyday lives. Based on extensive ethnographic fieldwork, the book shows that, notwithstanding the massive rollout of ART, providing treatment and living a life with HIV in settings like Tanga continue to entail social, economic, and moral challenges and long-term uncertainties, which contradict the global rhetoric of the “normalization of HIV”.
URBAN NATURES
Authors: Edwards Ferne , Popartan Lucia Alexandra , Pettersen Ida Nilstad
Published: October 2023

Efforts to create greener urban spaces have historically taken many forms, often disorganized and undisciplined. Recently, however, the push towards greener cities has evolved into a more cohesive movement. Drawing from multidisciplinary case studies, Urban Natures examines the possibilities of an ethical lively multi-species city with the understanding that humanity’s relationship to nature is politically constructed. Covering a wide range of sectors, cities, and urban spaces, as well as topics ranging from edible cities to issues of power, and more-than-human methodologies, this volume pushes our imagination of a green urban future.
The influence of mineral fertilizers and plant growth regulators on the development of clone rootstocks of apple trees 54-118 in container growing technology
Authors: Pomyaksheva L. V. , Borisova A. A. , Konovalov S. N. , Bychkov N. V.
Published: October 2023

When replicating apple tree planting material in protected soil, technologies for growing plants in container culture using an organomineral substrate, long-acting mineral fertilizers and plant growth regulators are widely used. The purpose of the research was to establish the effectiveness of the combined use of plant growth regulators and long-acting fertilizers when growing clonal apple rootstocks 54-118 in container technology in protected ground. The experiments were carried out in 2021-2023 according to generally accepted methods. The article presents the results of a study of the effect of joint use of OsmocotePRO long-acting fertilizer for 3-4 months. (17-11-10+2MgO+TE) and plant growth regulators indolyl-3-butyric acid (IBA) and gibberellic acid (GA3) on plant growth and development. These technology elements can be used both when obtaining planting material for planting mother plants of clonal rootstocks, and for obtaining seedlings.
Obtaining Evidence Protected by Banking Secrecy through European Investigation Order in Preparatory Proceedings. Remarks from the Polish Perspective
Authors: Smarzewski Marek Ryszard
Published: October 2023

The subject matter of considerations undertaken in the paper is the issue of obtaining evidence entailing banking secrecy under the European Investigation Order at the stage of the preparatory proceedings from the Polish perspective. The examination of the described evidence activity is often necessary to make key findings, for example, in the field of the data on bank accounts or bank transactions. Actions taken in this regard may concern the monitoring of banking opera­tions and may also be used for establishing financial links be­tween entities operating in different European Union Member States. The procedure for applying the European Investigation Order generates many problems in the analysed scope, in par­ticular at the stage of the preparatory proceedings, starting from determining the authority competent to issue the European In­vestigation Order, to the need to consider legitimacy of obtain­ing the consent by the prosecutor to exempt from banking se­crecy in order to further request for the required information. Against the background of the issues presented in the article, an attempt was made to analyse the normative institution of the European Investigation Order, used for obtaining evidence covered by banking secrecy, and to show the model that deter­mines its optimal functioning in the face of existing problems in the application challenges related to the European cooperation in this area.
Winning Elections the Right Way: Online Political Advertising Rules in Europe and Selected Countries Globally
Authors: Heinmaa Thijs , Wolf Peter , Dalke Lisa-Marie , Neven Marilyn
Published: October 2023

As political campaigning in the lead-up to elections has moved online, parties and candidates have found new and innovative methods for connecting with voters. However, new challenges have multiplied, with the regulation and oversight authorities struggling to keep up. Campaign communications are increasingly opaque online, thus enabling harmful mis- and disinformation to influence electoral narratives. Moreover, it is harder to track the funding used for ads, and these communications may be targeted at voters on the basis of their personal data without their knowledge or consent. The main objective of this Report is to support legislators, oversight bodies and other regulators in developing rules for the regulation and oversight of online political advertising. It addresses questions including how to build on existing campaign regulation and what kind of unexpected consequences and challenges may occur; how to strike the right balance between regulation and protecting fundamental freedoms; how soft-law tools such as codes of conduct can help to increase campaign integrity and where they fall short; what an effective oversight institution looks like and how it is coordinated; and what sanctions can help to ensure effective enforcement.
How Can Transformer Models Shape Future Healthcare: A Qualitative Study
Authors: Denecke Kerstin , May Richard , Rivera Romero Octavio
Published: October 2023

Transformer models have been successfully applied to various natural language processing and machine translation tasks in recent years, e.g. automatic language understanding. With the advent of more efficient and reliable models (e.g. GPT-3), there is a growing potential for automating time-consuming tasks that could be of particular benefit in healthcare to improve clinical outcomes. This paper aims at summarizing potential use cases of transformer models for future healthcare applications. Precisely, we conducted a survey asking experts on their ideas and reflections for future use cases. We received 28 responses, analyzed using an adapted thematic analysis. Overall, 8 use case categories were identified including documentation and clinical coding, workflow and healthcare services, decision support, knowledge management, interaction support, patient education, health management, and public health monitoring. Future research should consider developing and testing the application of transformer models for such use cases.
Defining a Preprocessing Pipeline for the MULTI-SITA Project and General Medical Italian Natural Language Data
Authors: Cappello Alice ,   SITA (Italian Society of Anti-Infective Therapy), Mora Sara , Giacobbe Daniele Roberto , Bassetti Matteo , Giacomini Mauro
Published: October 2023

The application of Natural Language Processing (NLP) to medical data has revolutionized different aspects of health care. The benefits obtained from the implementation of this technique spill over into several areas, including in the implementation of chatbots, which can provide medical assistance remotely. Every possible application of NLP depends on one first main step: the pre-processing of the corpus retrieved. The raw data must be prepared with the aim to be used efficiently for further analysis. Considerable progress has been made in this direction for the English language but for other languages, such as Italian, the state of the art is not equivalently advanced, especially for texts containing technical medical terms. The aim of this work is to identify and develop a preprocessing pipeline suitable for medical data written in Italian. The pipeline has been developed in Python environment, employing Enchant, ntlk modules and Hugging Face’s BERT and BART-based models. Then, it has been tested on real conversations typed between patients and physicians regarding medical questions. The algorithm has been developed within the MULTI-SITA project of the Italian Society of Anti-Infective Therapy (SITA), but shows a flexible structure that can adapt to a large variety of data.
Early Experiences of Integrating an Artificial Intelligence-Based Diagnostic Decision Support System into Radiology Settings: A Qualitative Study
Authors: Farič Nuša , Hinder Sue , Williams Robin , Ramaesh Rishi , Bernabeu Miguel O. , van Beek Edwin , Cresswell Kathrin
Published: October 2023

Background: Artificial Intelligence (AI) based clinical decision support systems to aid diagnosis are increasingly being developed and implemented but with limited understanding of how such systems integrate with existing clinical work and organizational practices. We explored the early experiences of stakeholders using an AI-based e-learning imaging software tool Veye Lung Nodules (VLN) aiding the detection, classification, and measurement of pulmonary nodules in computed tomography scans of the chest. We performed semi-structured interviews and observations across early adopter deployment sites with clinicians, strategic decision-makers, suppliers, patients with long-term chest conditions, and academics with expertise in the use of diagnostic AI in radiology settings. We coded the data using the Technology, People, Organizations and Macro-environmental factors framework (TPOM). We conducted 39 interviews. Clinicians reported VLN to be easy to use with little disruption to the workflow. There were differences in patterns of use between experts and novice users with experts critically evaluating system recommendations and actively compensating for system limitations to achieve more reliable performance. Patients also viewed the tool positively. There were contextual variations in tool performance and use between different hospital sites and different use cases. Implementation challenges included integration with existing information systems, data protection, and perceived issues surrounding wider and sustained adoption, including procurement costs. Tool performance was variable, affected by integration into workflows and divisions of labor and knowledge, as well as technical configuration and infrastructure. These under-researched factors require attention and further research.
Economic efficiency of long-term oxygen therapy in patients with chronic lung diseases and severe chronic hypoxemia
Authors:   I.P. Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russian Federation, Gomon Yu.M. , Titova O.N. ,   I.P. Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russian Federation, Kolbin A.S. ,   I.P. Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russian Federation,   St. Petersburg State University, St. Petersburg, Russian Federation, Kuzubova N.A. ,   I.P. Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russian Federation,   Vvedenskaya Hospital, St. Petersburg, Russian Federation, Balykina Yu.E. ,   St. Petersburg State University, St. Petersburg, Russian Federation
Published: October 2023

Background: long-term oxygen therapy (LTOT) for chronic lung diseases associated with chronic hy-poxemia is effective in terms of increasing life expectancy. However, by now, the costs of LTOT are not reimbursed by the healthcare system of the Russian Federation. Aim: to evaluate the economic efficiency of respiratory therapy centers in providing pa-tients with chronic lung diseases and severe chronic hypoxemia with LTOT at home. Patients and Methods: direct medical and nonmedical costs associated with the introduc-tion of LTOT into clinical practice were identified and calculated. Costs of LTOT, outpatient management of patients without exacerbations, treatment for exacerbations, and disability-related payments were considered. Clinical and economic modeling was performed. A cost-effectiveness analysis was performed and the budget impact was assessed. Published data and the experience of St. Petersburg Regional Respiratory Support Center were used to evaluate LTOT efficacy. Results: additional costs for LTOT per patient for 5 years are 229,759 RUB. LTOT signif-icantly (by 74%) reduce the costs of treating patients with exacerbations of chronic obstructive pulmonary disease, mainly due to a reduction in exacerbation rate, including those requiring ad- mission to hospital. Analysis of budget impact over 5 years demonstrates a decrease in direct medical costs per 100 oxygen concentrators by 32% (from 181,666,728.90 RUB to 123,247,630.82 RUB). Given mortality, the estimated number of patients opting for LTOT using 100 oxygen concentrators over 5 years is 150. Conclusions: reimbursement for LTOT costs in Russian healthcare is economically reason-able. KEYWORDS: long-term oxygen therapy, economic efficiency, respiratory therapy center, cost-effectiveness analysis, chronic hypoxemia. FOR CITATION: Gomon Yu.M., Titova O.N., Kolbin A.S., Kuzubova N.A., Balykina Yu.E. Economic efficiency of long-term oxygen therapy in patients with chronic lung diseases and severe chronic hypoxemia. Russian Medical Inquiry. 2023;7(8):475–481 (in Russ.). DOI: 10.32364/2587-6821-2023-7-8-1.
Legal documents regulating medical care for chronic suppurative otitis media
Authors:   St. Petersburg Research Institute of Ear, Throat, Nose, and Speech, St. Petersburg, Russian Federation, Komarov M.V. , Dvoryanchikov V.V. ,   St. Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russian Federation
Published: October 2023

Current regulatory documents of national importance that directly regulate medical care for chronic suppurative otitis media include the Federal Law "Basics of Health Protection of the Citizens in the Russian Federation", seven orders of the Ministry of Health and its predecessors, and Clinical Guidelines of the National Medical Association of Otolaryngologists. From general to specific according to the legal hierarchy, each document determines the regulations, routing, amount, and quality of medical care down to the smallest detail in various conditions and age groups. Chronic suppurative otitis media is a group of diseases that are expensive to treat and associated with a high risk of early and delayed complications. Therefore, many documents (which often conflict with each other) are dedicated to medical care standardization. Despite the outdatedness and, often, the difficulty of practical implementation of some recommendations specified in the regulatory documents, all of them are mandatory for implementation throughout the Russian Federation. KEYWORDS: chronic suppurative otitis media, standard, clinical guidelines, procedure for providing medical care, evaluation of medical care quality. FOR CITATION: Komarov M.V., Dvoryanchikov V.V. Legal documents regulating medical care for chronic suppurative otitis media. Russian Medical Inquiry. 2023;7(8):529–536 (in Russ.). DOI: 10.32364/2587-6821-2023-7-8-9.
Insulin Sensitizers as Anti-Aging Agents: Exploring the Role of Albumin and its Implications for Healthy Aging
Authors: Ahmed Amr , Akl Maher M.
Published: October 2023

This manuscript delves into the potential of insulin sensitizers, specifically Metformin and GLP1 with Degludec, as anti-aging agents, focusing on the multifaceted functions of albumin and its association with age-related changes.
Long COVID in Mexico – Research Efforts
Authors: del Carpio-Orantes Luis , Aguilar-Silva Andrés , Lara-Hernández Estefanía , Rodriguez-Contreras Yamir , Fernández-Márquez Daniela , Trelles-Hernández Daniela , López-Vargas Ener René
Published: October 2023

In this communication, a review is made of the main reports on Long COVID carried out in Mexico, as research efforts that will help characterize this affected population and subsequently favor the creation of clinical practice guidelines.
Cómo solicitar una evaluación fiscal agrícola Greenbelt
Authors: Thomas Raychel , Caracciolo Jana , Campbell Catherine , Diaz John , Caicedo Zapata Valeria
Published: October 2023

Esta publicación de EDIS está diseñada para proporcionar un resumen preciso y actual de la Ley Greenbelt de Florida. Esta publicación se distribuye con el entendimiento de que los autores no se dedican a prestar asesoramiento legal u otro asesoramiento profesional, y la información contenida en este documento no debe considerarse como un sustituto del asesoramiento profesional. Este documento es el FCS3358-Span, uno de una serie del Departmento de Familia, Juventud y Ciencias Comunitarias, UF/IFAS Extensión. Publicación original de agosto del 2023.
Locating Selection and Resource Allocation After a Possible Earthquake in Amol City
Authors:   Department of Industrial and Systems Engineering, Isfahan University of Technology, Isfahan, Iran., Zamani Hamed , Parvaresh Fereshteh ,   Department of Industrial and Systems Engineering, Isfahan University of Technology, Isfahan, Iran.
Published: October 2023

Background and objective Transferring injured people to medical centers is one of the important challenges of providing relief in natural and man-made disasters. Often, due to the damage caused by the disaster, it is not possible to transfer the injured to safe medical centers in the short term. Establishing field hospitals in suitable places is one of the common solutions in these situations. This study aims address the problem of location selection for field hospitals using mathematical modeling and asses how to allocate resources, including medical staff and needed medications by the temporary hospitals. Method This study presents an integer programming model for the location selection problem. To evaluate the proposed model, the real data from Amol City was collected and used as inputs. The optimal solution was determined using GAMS 25.1 optimization software. Results The calculation results illustrated the best place for the establishment of field hospitals, which is located in Banafsheh Park. It has also been determined that each deployed field hospital should have 60 beds. In addition, the optimal number of medical personnel and relief vehicles for relief operations was determined. The sensitivity analysis has also shown that if any of the hospitals located in Amol is damaged and inactive due to an accident, Hefdeh Shahrivar Square is a suitable place to build a field hospital. Conclusion The results of this study can help authorities in Amol city to make the best decisions regarding where to establish field hospitals and how to use the limited available resources during disasters. The main innovation of the presented model also is the location of field hospitals along with considering the active hospitals around the affected areas so that the injured can be transferred to the active hospitals in addition to the constructed field hospitals. In this model, a constraint has been applied to complete the service time, so that the rescue vehicles have a limited time to transport the injured to the rescue centers.