bluuebunny/crossref_metadata_2025 huggingface dataset:
Le Voyage d’Espagne (1736) de Guillaume Manier: un carrefour intertextuel
Authors: Iñarrea Las Heras Ignacio
Published: January 2019

Dans le présent article on veut montrer que le récit intitulé Voyage d’Espagne, écrit en 1736 par le pèlerin français Guillaume Manier, est un lieu de confluence d’une quantité considérable d’éléments intertextuels très variés. On y trouve des documents bureaucratiques (civils et ecclésiastiques), des relations de reliques, des traités pour combattre des maladies, des allusions à d’autres créations littéraires et même musicales, des passages plagiés… Voilà donc tout un ensemble de productions écrites qui enrichit énormément le Voyage d’Espagne, en lui donnant une complexité et une profondeur significative non négligeables.En el presente artículo se pretende mostrar que el relato titulado Voyage d’Espagne, escrito en 1736 por el peregrino francés Guillaume Manier, es un lugar de confluencia de una cantidad considerable de elementos intertextuales muy variados. Hay en él documentos burocráticos (civiles y eclesiásticos), listas de reliquias, tratados para combatir enfermedades, alusiones a otras creaciones literarias e incluso musicales, pasajes plagiados… Se trata, pues, de todo un conjunto de producciones escritas que enriquece enormemente el Voyage d’Espagne, dándole una complejidad y una profundidad significativa nada desdeñables.
Representaciones léxicas de los predicados afijales en el modelo léxico construccional: el prefijo inter–
Authors: Sosa Acevedo Eulalia
Published: January 2019

Este artículo presenta, a través del análisis del prefijo locativo inglés inter-, una propuesta para el desarrollo de un componente de formación de palabras compatible con el Modelo Léxico Construccional, MLC (v. Ruiz de Mendoza y Mairal Usón 2008, Mairal Usón y Ruiz de Mendoza 2009). En su diseño más reciente, el MLC da cuenta de un conjunto de procesos semántico-sintácticos que intervienen en la construcción del significado en sus distintos niveles, para lo cual se utilizan como sistema de representación las denominadas Plantillas Léxicas. De forma similar, en el contexto de nuestra propuesta se desarrollan Plantillas Morfológicas que facilitan una descripción adecuada tanto de la estructura interna o «microestructura» como de la «macroestructura» u arquitectura onomasiológica de los afijos en el componente Lexicón.This paper presents an analysis of the English prefix inter- as a proposal for a wordformation component compatible with the Lexical Constructional Model, LCM (see Ruiz de Mendoza y Mairal Usón 2008, Mairal Usón y Ruiz de Mendoza 2009). In its more recent design, the LCM accounts for the semantic-syntactic processes involved in the construction of meaning at all the levels of linguistic organization by means of Lexical Templates. In a similar way, we formulate Morphological Templates which provide an adequate description of both the internal structure or «micro-structure» and the «macrostructure » or onomasiological architecture of affixes within the Lexicon component.
El papel de los diccionarios pedagógicos especializados en la enseñanza/aprendizaje del ESP
Authors: Fuertes-Olivera Pedro A. , Pérez Cabello de Alba Beatriz
Published: January 2019

Con el nombre de Inglés para Fines Específicos, mas conocido por el acrónimo inglés ESP, nos referimos a la variedad de la lengua inglesa que se enseña a los estudiantes matriculados en carreras como Económicas, Turismo, Medicina e Ingenierías. Desde sus inicios hasta la fecha hemos asistido a un gran crecimiento en el número de estudiantes y cursos ofertados, que ha obligado a poner en marcha prácticas docentes autónomas, es decir sin la participación de expertos en el campo, y replicativas, es decir prácticas que fueron inicialmente diseñadas para el aprendizaje de las destrezas profesionales, como por ejemplo el uso del estudio de casos procedente de los Masters of Business Administration (MBA). Ambos procesos, unidos al desarrollo del inglés como lingua franca y al interés por el desarrollo de una metodología que favorezca la autonomía de los estudiantes, se han traducido en un desarrollo espectacular de herramientas docentes de Internet. En este marco se sitúa este trabajo que se organiza en tres grandes apartados: (1) una precisión del concepto de ESP y una reinterpretación del mismo; (2) una revisión del concepto de lexicografía y del diccionario pedagógico; (3) una descripción de las posibilidades que ofrecen los diccionarios de Internet para poder leer textos de inglés empresarial/inglés económico. El artículo finaliza resumiendo las principales ideas defendidas en este trabajo.From its inception in the early 1960s, English for Specific Purposes (ESP) has grown to become one of the most prominent areas of EFL teaching. ESP is usually concerned with the teaching of English used in academic studies and/or professional activities, especially the teaching of English related with Business/Economics, Tourism, Medicine, and Engineering. As the number of courses and students has grown considerably the original team teaching methodology is being substituted by a more autonomous approach in which both ESP instructors and students have to acquire knowledge of the basic concepts of the field by themselves, as well as upgrade their discourse competence. This new approach lends support to recent developments in the field of learner’s autonomy, especially those based on Internet (for example, Moodle) that are being promoted in this era of shortages and lack of resources. Within this framework, this article offers a review of the state of art regarding ESP, formulates a reconceptualization of the concept with the aim of making room to two recent developments: the consolidation of English as lingua franca; and the possibilities offered by the Internet for teaching and learning. It also enumerates the main basic requirements of pedagogically-oriented specialised dictionaries and illustrates some of their potentialities for assisting users in a reading situation. The article finishes by summarising the main conclusions drawn.
Las ediciones de Pomponio Mela en España: análisis de la tradición incunable
Authors: Carrizo Gómez María José
Published: January 2019

El objeto de este artículo es analizar el patrimonio de la tradición incunable de la Cosmographia de Pomponio Mela conservado en España, centrando la atención en el examen de los ejemplares que se encuentran en fondos bibliográficos españoles con el fin de esclarecer la difusión y las modalidades de recepción de la obra de Mela en España.The purpose of this paper is to analyze the heritage of Pomponio Mela’s Cosmographia incunable tradition preserved in Spain, focusing on the revision of the copies which are kept in Spanish bibliographic reserved collections in order to clarify the diffusion and the different ways of reception of Mela’s work in Spain.
Niveles de utilización de las fuentes clásicas en La fiera, el rayo y la piedra de Calderón de la Barca
Authors: Bravo Ramón F. Javier
Published: January 2019

La primera de las grandes representaciones calderonianas de carácter operístico se inscribe en los hitos del género por la confluencia de sus componentes básicos: el textual, el escenográfico y el musical. Se trata de la primera vez en la que colaboraron Calderón y Baccio del Bianco y sentó las bases de proyectos posteriores. Nos interesa en este artículo analizar de qué forma las referencias clásicas recorren el texto calderoniano, como soporte retórico de las distintas fábulas que se relatan, pero también como eje vertebrador de la historia en sus diversos niveles de utilización.The first of the great Calderonian performances, with operatic characteristics, is etched in history as one of the significant landmark of the genre, because of the confluence of its main components: text, sets and music. It was the first partnership of Calderón and Baccio del Bianco and it laid the foundations for subsequent works. The topic of this article is about the way the classical references run through the Calderonian plays, how the fables form their rhetorical basis and the spine around which the plot and other aspects of the play are built.
Los hilos de la trama oscura: la diversidad teológica en la poesía de Borges
Authors: Núñez Díaz Pablo
Published: January 2019

El objetivo de este artículo es mostrar el carácter heterogéneo de las referencias teológicas que aparecen en los poemas de Jorge Luis Borges. En ellos, el autor aborda literariamente –y a veces transforma– temas relacionados con la historia sagrada y con doctrinas de distintas tradiciones eclesiales. Se hará especial hincapié en la pluralidad de ideas soteriológicas y escatológicas. Por otro lado, a pesar del agnosticismo de Borges, la voz que habla en sus poemas se muestra en ocasiones como creyente, mientras que otras veces expresa sus dudas o claramente su incredulidad.The aim of this paper is to show the heterogeneous character of the theological references that appear in Jorge Luis Borges’s poems. The author approaches them as literature, and sometimes transforms topics related to sacred history and doctrines from different ecclesial traditions. We will put special emphasis on the plurality of soteriological and eschatological ideas. Despite Borges’ agnosticism, the voice that speaks in his poems displays at times a believer’s concern, while at other times it reveals his doubts or sheer incredulity.
Notas sobre los estudios literarios de Pedro Salinas (1930-1940)
Authors: Abad Nebot Francisco
Published: January 2019

Estas Notas analizan –sobre fuentes primarias– los primeros libros o escritos de Pedro Salinas en tanto crítico literario.
La crítica textual en el comentario de textos griegos (con algunos ejemplos de Eurípides).
Authors: Lasso de la Vega José S.
Published: January 2019

-
El cazador cazado: intertextualidad en los Guillermo Tell de Alfonso Sastre.
Authors: Gorlee Dinda L.
Published: January 2019

-
Teatro y religión en la España de Felipe II: el Códice de Autos Viejos.
Authors: Pérez Priego Miguel Ángel
Published: January 2019

-
El latín de la Peregrinatio hispánica (1531-1533) de Claude de Bronseval.
Authors: Calero Francisco
Published: January 2019

-
Léxico y contexto situacional en el ideario poético de Gary Snyder.
Authors: Fernández Leal María del Carmen
Published: January 2019

-
Jane, la mujer providencial de Pedro en La sombra del ciprés es alargada de Miguel Delibes.
Authors: Postman Sheryl Lynn
Published: January 2019

-
La caracterización estilística de las cláusulas anómalas en el hexámetro latino.
Authors: Arribas Hernández María Luisa
Published: January 2019

-
Los estudios de lengua literaria de la escuela española.
Authors: Abad Nebot Francisco
Published: January 2019

-
La teoría de la traducción del maestro Baltasar Céspedes.
Authors: Calero Francisco
Published: January 2019

-
Le Geolier de soi-même o Jodelet Prince, de Thomas Corneille: comicidad situacional y lingüística de un personaje.
Authors: Serrano Mañes Montserrat
Published: January 2019

-
La obra poética de Angel García López.
Authors: Granados Vicente
Published: January 2019

-
Estudio de algunas unidades lingüísticas designativas (1).
Authors: Otaola Olano Concepción
Published: January 2019

-
La ejemplaridad fonética en la poesía modernista (Julio Herrera y Reissig).
Authors: Estévez Rodríguez Ángeles
Published: January 2019

-
Las acotaciones de Rosso di San Secondo a su Marionette, che passione!.
Authors: Martínez-Peñuela Virseda Ana
Published: January 2019

-
La noción de tema y la interpretación de los indefinidos.
Authors: Leonetti Jungl Manuel
Published: January 2019

-
Retórica y semiótica: hacia una poética general.
Authors: Grande Rosales María de los Ángeles
Published: January 2019

-
Lingüística e historiografía : a propósito de un libro sobre las nominalizaciones en Tucídides
Authors: Campos Daroca Javier
Published: January 2019

-
La epístola como elemento constitutivo de otra obra literaria en la literatura griega
Authors: Barrio Vega María Luisa del
Published: January 2019

-
Usos paralelos del infinitivo en latín e inglés: estilo indirecto y complementación.
Authors: García Fuentes María Cruz , Ortega Calvo Ángeles
Published: January 2019

-
Stendhal o la épica del yo: estudio comparativo de la autobiografía y la ficción.
Authors: Bueno García Antonio
Published: January 2019

-
A propósito de "Le comte Ory": Farmoutier, Rossini, Mozart.
Authors: Delgado Arturo
Published: January 2019

-
Historia de la lengua: historia de la ciencia literaria (dos análisis bibliográficos)
Authors: Abad Nebot Francisco
Published: January 2019

-
Adaptaciones de la novela al cine: Un amour de Swann, de Volker Schlondorff (1983).
Authors: Delgado Arturo
Published: January 2019

-
Lengua y estilo en Cántico de Jorge Guillén.
Authors: Reboiro Victoria G.
Published: January 2019

-
Del latín al romance: algunas observaciones sobre los verbos de encontrar (II).
Authors: Domínguez Domínguez Juan Francisco
Published: January 2019

-
Challenges in Modeling of Turbulence in the Tip Region of Axial Turbomachines
Authors: Li Yuanchao , Chen Huang , Katz Joseph
Published: January 2019

The flow and turbulence in turbomachines are characterized by spatially and temporally nonuniform strain rate fields and tendency to develop partially understood large-scale instabilities. Consequently, the applicability of popular Reynolds stress models in Reynolds-averaged Navier-Stokes simulations of turbomachinery flows is questionable and requires validation under relevant conditions. Experimental studies performed in the Johns Hopkins University optical refractive index-matched facility have investigated the complex flow and turbulence in the blade tip region of several axial turbomachines, including two waterjet pumps and an aviation compressor. The comprehensive databases obtained for different flow conditions and tip geometry using high-resolution particle image velocimetry are used in this article to examine the characteristics of turbulence in the vicinity of the tip leakage vortex (TLV). The results reveal several common features in the spatial distribution of the extremely anisotropic Reynolds stress tensor, suggesting that there are similarities in the mechanisms involved among the different machines. Of the quantities that could be measured accurately, both the local production and mean-flow advection rates appear to govern the evolution of turbulence in the passage. The dissipation rate also appears to be a major factor, but it cannot be measured accurately because of its dependence on motions at small scales that are not resolved by the measurements. The turbulent transport terms are important only in limited cases and locations. The strain rate tensor components, which appear to play primary roles in the production of turbulent kinetic energy (TKE), display common features in the spatial distributions of regions with high contraction, extension, and shear under different conditions. Some but not all of the inhomogeneity and anisotropy in the distributions of Reynolds stresses can be related to the corresponding local production rates. There is disagreement near the TLV core, where the persistent presence of multiple interacting vortices contributes significantly to the elevated TKE there. Lack of a clear functional correlation between the Reynolds stresses and mean strain rates is ubiquitous in all cases, resulting in widely spatially varying positive and negative values for the eddy viscosity. However, surprisingly, results from different machines and conditions have similar spatial distributions of individual stress and strain rate components and, accordingly, the eddy viscosity.
MULTICAGE CAD-4: Psychometric characteristics for the screening of addictive behaviors
Authors: Rodríguez Monje Mª Teresa , Pedrero Pérez Eduardo J. , Rodríguez Monje Mª Teresa , Rodríguez Alonso Elías , Rodríguez Alonso Elías , Fernández Girón Mercedes , Fernández Girón Mercedes , Mateo Madurga Alicia , Mateo Madurga Alicia , Arana Cañedo-Argüelles Celina , Arana Cañedo-Argüelles Celina , Pastor Ramos Victoria , Pastor Ramos Victoria , Sánchez Salgado Mª Paz , Sánchez Salgado Mª Paz , Escriva Ferrairo Rosa Ana , Escriva Ferrairo Rosa Ana , Del Cura González Isabel , Del Cura González Isabel , Sanz Cuesta Teresa , Sanz Cuesta Teresa
Published: January 2019

Addictive behaviors are not limited to drugs use, but also include certain daily behaviors that can cause gratification. Their progression to more severe pathological patterns entails grave consequences for the individual, including multiple psychopathological manifestations. The early detection of this type of behavior is of concern to primary health care. Therefore, in order to detect risk at early stages, reliable and valid tools for daily practice are essential. The MULTICAGE CAD-4 questionnaire is a screening tool for simultaneously detecting addictive behaviors. This study includes a new scale for the detection of smartphone abuse. The objective is to evaluate the adequacy of its psychometric properties. A sample of 2,074 subjects that were recruited from primary care centers ofMadrid(Spain) completed the MULTICAGE CAD-4 questionnaire. A confirmatory factor analysis, using unweighted least squares method, was performed. The test showed good internal consistency both at item and scale levels. The questionnaire structure was consistent with theoretical expectations. The MULTICAGE CAD-4, including the new smartphone scale, is a robust, reliable tool with a valid structure for assessing the presence of dysfunctional or potentially addictive behaviors, and especially useful in primary health care services.
Perfectionism and sporting practice. Functional stress regulation in adolescence
Authors: González-Hernández Juan , Muñoz-Villena Antonio Jesús
Published: January 2019

Systematic practice of physical activity (PA) in childhood and adolescence enables the development of functional resources for subjective perception of well-being, stimulation of cognitive processes, and construction of the personality. The development of perfectionist beliefs is currently seen as a functional characteristic linked to positive aspects (positive affect, self-esteem, etc.), while its dysfunctional aspects have been associated with anxiety and stress. The aim of this study is to identify which indicators of perfectionism provide functional conditions/skills that, in combination with the level of practice of physical activity, facilitate stress regulation. A sample of 365 adolescents (183 girls and 182 boys) aged between 13 and 17 participated. The results show that as the intensity of physical activity increases, there are significant changes in the indicators for functional perfectionism (high personal standards and organisation), with reference to facilitating (at moderate levels) or limiting (if excessive or absent) perceived stress and, above all, increased intensity of physical activity accentuates dysfunctional perfectionism patterns. This research has made it possible to identify active psychological processes that influence functional or dysfunctional psychological responses in adolescents depending on their level of perfectionism and the intensity of practise of PA.
Turning Travelogue readers into tourists: representations of tourism destinations through linguistic features
Authors: Potočnik Topler Jasna
Published: January 2019

This article is focused on the language of tourism as a means of economic potential. Language in tourism, especially language of promotional texts, motivates and attracts tourists to visit a certain destination, and, consequently, makes profits. In its introductory part, the article offers a short theoretical insight into the functions of tourism discourse and, further on, Rick Steves‘ website texts (travelogues) about European destinations are examined through discourse analysis, more precisely linguistic analysis involving analysis of syntax, semantics, and pragmatics. The results confirming the importance of lexical choices in tourism discourse are presented and discussed at the end of the article. Steves’ travelogues aim to turn potential tourists into actual tourists by employing language, rich in stylistic devices and lexical imagery. The texts convince the potential tourists actually to buy the tourism services and products promoted in the texts. Thus, Steves’ texts are examples of positive branding which aim to attract business. The research is orginial in the sense that it is concentrated on linguistic analysis of persuasive features based on discursive theories.
Recesión en la ocupación hotelera a partir de tres acontecimientos: terremoto, cierre de aeropuerto, construcción de tranvía. Caso Cuenca (Ecuador)
Authors: Serrano López Ana Lucía , Freire-Chaglla Segundo , Sanmartín-Rojas Ileana , Espinoza-Figueroa Freddy
Published: January 2019

En Ecuador, el turismo representa la cuarta fuente de ingresos de los productos exporta¬dos, con un aporte de 1.433 millones de dólares a precios constantes y es equivalente al 1.5% de contribución al producto interno bruto para el año 20161. Para el estudio la Ocupación Hotelera se calculó de acuerdo a la Norma Eurostat 2012. La evaluación de los tres factores de la investigación, los resultados en la ocupación de alojamiento fueron los siguientes: 10% menos en la ocupación por el cierre del aeropuerto, 6% menos por la ejecución de la red tranviaria y 3% menos por el terremoto. Con el primer evento (construcción del Tranvía) descendió al 28,1%; con dos eventos (construcción del Tranvía y aeropuerto sin funcio¬namiento) al 22,2%; y, cuando ocurren los tres eventos desciende al 17%; por lo tanto, los eventos estudiados afectan negativamente la imagen del destino.
Modelización de la movilidad en los rankings de hoteles
Authors: Ximénez-de-Sandoval José-Luis , Fernández-Morales Antonio , Guevara-Plaza Antonio
Published: January 2019

El ranking de hoteles de TripAdvisor, ha sido analizado desde múltiples perspectivas, pero son pocos los investigadores que han estudiado su evolución temporal. Este artículo presenta uno de los primeros trabajos sobre la movilidad en los rankings de hoteles. Dis¬tinguimos entre rankings líquidos, y sólidos, definimos la Movilidad de un ranking, dis-tinguiendo entre micro y macromovilidad. Además, introducimos el concepto de vector trayectoria como objeto central del análisis. Por último, presentamos un modelo para medir la movilidad, que se aplicará a una muestra de 771 hoteles de ciudades españolas.
Cognitive Behavioral Therapy for the Management of Multiple Sclerosis–Related Pain
Authors: Gromisch Elizabeth S. , Kerns Robert D. , Czlapinski Rebecca , Beenken Beth , Otis John , Lo Albert C. , Beauvais John
Published: January 2019

Background:

Pain is a common and often debilitating symptom in persons with multiple sclerosis (MS). Besides interfering with daily functioning, pain in MS is associated with higher levels of depression and anxiety. Although cognitive behavioral therapy (CBT) for pain has been found to be an effective treatment in other populations, there has been a dearth of research in persons with MS.

Methods:

Persons with MS with at least moderate pain severity (N = 20) were randomly assigned to one of two groups: CBT plus standard care or MS-related education plus standard care, each of which met for 12 sessions. Changes in pain severity, pain interference, and depressive symptom severity from baseline to 15-week follow-up were assessed using a 2×2 factorial design. Participants also rated their satisfaction with their treatment and accomplishment of personally meaningful behavioral goals.

Results:

Both treatment groups rated their treatment satisfaction as very high and their behavioral goals as largely met, although only the CBT plus standard care group's mean goal accomplishment ratings represented significant improvement. Although there were no significant differences between groups after treatment on the three primary outcomes, there was an overall improvement over time for pain severity, pain interference, and depressive symptom severity.

Conclusions:

Cognitive behavioral therapy or education-based programs may be helpful adjunctive treatments for persons with MS experiencing pain.
Development and Preliminary Evaluation of a 3-Week Inpatient Energy Management Education Program for People with Multiple Sclerosis–Related Fatigue
Authors: Hersche Ruth , Weise Andrea , Michel Gisela , Kesselring Jürg , Barbero Marco , Kool Jan
Published: January 2019

Background:

Energy conservation strategies and cognitive behavioral therapy techniques are valid parts of outpatient fatigue management education in people with multiple sclerosis (MS). In many European countries, multidisciplinary rehabilitation for people with MS is chiefly delivered in specialized rehabilitation centers, where they benefit from short intensive inpatient rehabilitation annually. However, no evidence-based and standardized fatigue management education program compatible with the inpatient setting is available.

Methods:

Based on a literature search and the expertise of occupational therapists (OTs), a manualized group-based Inpatient Energy Management Education (IEME) program for use during 3-week inpatient rehabilitation that incorporates energy conservation and cognitive behavioral management approaches was developed. An IEME pilot program operated by trained OTs included 13 people with MS-related fatigue. The experiences of the IEME users and OTs were collected during focus groups to refine the program's materials and verify its feasibility in the inpatient setting.

Results:

The program was feasible in an inpatient setting and met the needs of the people with MS. Targeted behaviors were taught to all participants in a clinical context. In-charge OTs were able to effect behavioral change through IEME.

Conclusions:

Users evaluated the evidence-based IEME program positively. The topics, supporting materials, and self-training tasks are useful for the promotion and facilitation of behavioral change. The next step is a clinical trial to investigate the efficacy of IEME and to evaluate relevant changes in self-efficacy, fatigue impact, and quality of life after patients return home.
HISTOLOŠKI I IMUNOHISTOHEMIJSKI PARAMETRI BITNI ZA KLASIFIKACIJU MASTOCITOMA PASA
Authors: Vučićević Ivana , Marinković Darko , Kukolj Vladimir , Nešić Slađan , Aničić Milan , Aleksić-Kovačević Sanja
Published: January 2019

Mastocitomi su najučestaliji tumori kože pasa. Vode poreklo izkostne srži, a zbog vrlo promenljivog biološkog ponašanja je predloženo nekolikokriterijuma za njihovu klasifikaciju, uključujući histološku gradaciju i markereproliferacije ćelija. Mitotski indeks, prisustvo višejedarnih ćelija, ćelija sa bizarnimjedrom i kariomegalija su najvažniji parametri za klasifikaciju mastocitoma pasa namastocitome visokog i niskog stepena maligniteta. Za potvrdu stepena malignitetamastocitoma bitno je utvrditi i ekspresiju transmembranskog receptora kinaza tipa(KIT) koji igra značajnu ulogu u rastu i diferencijaciji mastocita, a koga kodira c-KITprotoonkogen. Kod mastocitoma visokog stepena maligniteta, osim membranskeekspresije KIT receptora, može se uočiti i aberantna citoplazmatska ekspresija.Ispitana su ukupno 52 mastocitoma pasa i 12 uzoraka nepromenjene kože pasa.Uzorci kože fiksirani u formalinu i ukalupljeni u parafinu su obojeni hematoksilineozinom.Ekspresija KIT receptora je ispitana primenom imunohistohemijskemetode bojenja. Klasifikacija mastocitoma na mastocitome visokog i niskog stepenamaligniteta je izvršena prema kriterijumima Kiupel-ove dvostepene klasifikacije,uzimajući u obzir i ekspresiju KIT receptora. Od ukupno 52 mastocitoma pasa 16je bilo niskog stepena maligniteta, dok je 36 klasifikovano kao mastocitomi visokogstepena maligniteta, od kojih 19 mastocitoma pokazuje citoplazmatsku ekspresijuKIT receptora. Kod svih 16 mastocitoma niskog stepena maligniteta ispoljena jesamo membranska ekspresija KIT proteina. Činjenica da je kod većine mastocitomavisokog stepena maligniteta ispoljena ekspresija KIT receptora u citoplazmi potvrđujevezu između aberantne ekspresije KIT receptora i povećane ćelijske proliferacije.Prisustvo mitotskih figura, višejedarnih ćelija, bizarnih jedara i kariomegalije, kao i tip ekspresije KIT receptora predstavljaju ključne prognostičke parametre kod pasasa mastocitomima.
ZNAČAJ UPOTREBE ALERGIJSKOG KOŽNOG TESTA NA BRUCELIN U DIJAGNOSTICI BRUCELOZE GOVEDA
Authors: Velić Lejla , Eterović Toni , Špičić Silvio , Cvetnić Željko , Hrković Porobija Amina , Čengić Benjamin , Filipović Selma , Bajrović Tarik
Published: January 2019

Brucele u organizmu inficiranih životinja induciraju i humoralnii ćelijski imunološki odgovor. Humoralni imunološki odgovor se bazira na praćenjupojave specifičnih antitijela protiv glatkog lipopolisaharida (S-LPS) ćelijskemembrane brucela. Međutim kod goveda u dokazu specifičnih antitijela klasičnimserološkim metodama mogu se detetkovati antigene determinate za druge vrstemikroorganizama (unakrsna reaktivnost) kao što su: Escherichia coli 0:157, Yersiniaenterocolitica 0:9, Salmonella urban, Pseudomonas malthopilia i Pasteurellae. Cilj ovograda je utvrditi ćelijski imunološki odgovor koji se bazira na upotrebi pročišćenog istandardiziranog alergena, kojem je u potpunosti odstranjen lipopolisaharid te kaotakav ne dovodi do razvoja humoralnog imunološkog odgovora. Ukupno je ispitano16 goveda s područja Federacije Bosne i Hercegovine kod kojih je - Rose Bengaltestom ireakcijom vezivanja komplementa utvrđeno prisustvo specifičnih antitijelana brucelozu. Kožni test je izvođen prema uputama proizvođača. U testu je korištenbrucelin, ekstrakt B. melitensis B115 (Synbiotics Brucellergene OCB). Kod 14 govedaje nakon 72 sata od aplikacije utvrđeno zadebljanje kožnog nabora, dok kod dvagoveda nije izmjereno nikakvo zadebljanje. Razlog svakako treba tražiti u činjenicida su dva goveda imala pozitivan rezultat samo u Rose Bengal testu te se to možeprepisati unakrsnoj reakciji s antigeno srodnim mikroorganizmima.Kožni alergijski test nije preporučljiv kao samostalan dijagnostički alat jer nereaguju sve zaražene životinje, stoga ovaj test se ne može preporučiti kao individualnidijagnostički test ili u svrhu međunarodne trgovine. Međutim, zbog visokespecifičnosti i adekvatne osjetljivosti na nivou stada ili stada, može se preporučiti zanadzor stada / stada u područjima slobodnim od bruceloze.
ANTE MORTEM ДИЈАГНОСТИКА АЕLUROSTRONGYLUS ABSTRUSUS (RAILLIET, 1898) КОД ДОМАЋЕ МАЧКЕ У РЕПУБЛИЦИ СРПСКОЈ (БИХ)
Authors: ДОБРИЈЕВИЋ Миљан , СТЕВАНОВИЋ Оливер , ВУЈАНИЋ Дејан
Published: January 2019

У раду је описана појава верминозне бронхопнеумоније коддомаће мачке узроковане нематодом Аеlurostrongylus abstrusus (Railliet, 1898).Јединка мушког пола је у ранијим клиничким прегледима, показивала неке одзнакова респираторних сметњи, али дефинитвна дијагноза није постављена.С обзиром да је мачак остао у лошој кондицији, препоручен је копролошкипреглед. Након копролошке дијагностике и налаза развојних облика паразитаА. аbstrusus, извршен је поновни клинички преглед, рендгенографија грудногкоша и примјењена је терапија. На основу додатних анализа закључено је да јеријеч о хроничној елуростронгилози. Ово је први опис елуростронгилозе кодмачке у Републици Српској и Босни и Херцеговини, који указује на потребу да серутински копролошки прегледи спроводе у свакодневној ветеринарској пракси.
MASNO-KISELINSKI SASTAV LIVANJSKOG SIRA
Authors: HRKOVIĆ-POROBIJA Amina , HODŽIĆ Aida , VEGARA Mensur , VELIĆ Lejla , KAVAZOVIĆ Aida , SOFTIĆ Almira , MUTEVELIĆ Tarik , ŠALJIĆ Ermin
Published: January 2019

Tokom svoje 132-godišnje proizvodnje, karakteristike Livanjskogsira su se mijenjale, najprije zbog prelaska sa ovčijeg na kravlje mlijeko, odnosnonjihovu mješavinu. Livanjski sir svoju specifičnost može zahvaliti, prije svega,prisustvu specifičnog biljnog pokrivača planinskog područja, klimatskim uvjetima imlijeku autohtone ovce pramenke. Cilj ovoga rada je odrediti masno-kiselinski sastavLivanjskog sira, sa posebnim osvrtom na sadržaj bioaktivnih komponenti koje imajupozitivan efekat po zdravlje ljudi, kao i na praćenje eventualnih promjena u njihovomsadržaju u ovisnosti o periodu uzorkovanja, odnosno hranidbe. Za proizvodnjuLivanjskog sira, koji je uzorkovan nakon 90 dana zrenja u ambijentalnim uslovima,korišteno je zbirno mlijeko ovaca, uz napomenu da je ovčijem mlijeku dodavanokravlje, u odnosu (80:20) koji se uobičajeno koristi u tradicionalnoj proizvodnjiovog sira. Uzorci su analizirani gasnim hromatografom u laboratoriji „As Vitas“Oslo Innovation Centre, prema proceduri opisanoj u radu Luna i saradnici (2005).Ukupno su određene 24 masne kiseline, kroz tri vremenska perioda uzorkovanja(juli, august i septembar). U uzorcima sira, sadržaj zasićenih masnih kiselina (SFA)bio je veći u odnosu na mononezasićene (MUFA) i polinezasićene (PUFA). Sastavmasnih kiselina ispitivanih uzoraka sira je specifičan, jer sadrži masne kiseline zakoje je dokazano da imaju izuzetno povoljan efekat po ljudsko zdravlje.
TUBERCULOUS AND NONTUBERCULOUS MYCOBACTERIA IN HUMAN AND ANIMAL INFECTION
Authors: Cvetnić Željko , Zdelar Tuk Maja , Duvnjak Sanja , Reil Irena , Mikulić Marina , Pavlinec Željko , Cvetnić Marija , Špičić Silvio
Published: January 2019

Within the genus Mycobacterium (M.) more than 170 different types ofmycobacteria have been identified. In relation to humans, they are divided into threegroups. M. tuberculosis complex, which includes ten species that cause tuberculosisin mammals. The type of M. tuberculosis within M. tuberculosis complex remainsthe major cause of tuberculosis in humans in the world. Except for a long time knownspecies (M. bovis, M. africanum, M. microti, M. canetti, M. caprae), new membersof the group have recently been discovered. M. pinnipedii in seals, M. munghi inmongoose, M. orygis in arabian oryx and M. suricattae in the meerkat. The samecauses have been proven in people living nearby. M. leprae is the cause of theleprosy in humans. The disease has been proven in nine banded armadillos (Dasypusnovemcinctus) and represents the natural reservoir of M. leprae. The largest numberof mycobacteria (more than 160 species) belongs to nontuberculous mycobacteria.They are found in the environment, they are very resistant and adapted to growthand development, and to humans and animals are often exposed to them. Someare important potentially pathogenic species and they sometimes cause severepathological processes in humans and animals.
The role of transposable elements and DNA damage repair mechanisms in gene amplification and protein domain shuffling in plant genomes
Authors: Krasileva Ksenia V
Published: January 2019

Plant genomes are shaped by structural variation. Gene-size insertions and among most prominent events and can have significant effects on amplification of gene families as well as facilitate new gene fusions. Transposable elements as well as plant DNA repair machinery have overlapping contributions to these events, and often work in synergy. Activity of transposable elements is often lineage specific and can preferentially affect specific gene families, such as disease resistance genes. Once duplicated, genes themselves can serve templates for additional variation that can arise from non-allelic homologous recombination. Non-homologous DNA repair mechanisms contribute to additional variation and diversify the mechanisms of gene movement, such as through ligation of extra-chromosomal DNA fragments. Genomic processes that generate structural variation can be induced by stress and therefore can provide adaptive potential. This review describes mechanisms that contribute to gene-size structural variation in plants, specifically gene duplication and generation of new plant genes through gene fusion.
Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function
Authors: Gerber Daniel , Ghidinelli Monica , Tinelli Elisa , Somandin Christian , Gerber Joanne , Pereira Jorge A , Ommer Andrea , Figlia Gianluca , Miehe Michaela , Nägeli Lukas G , Suter Vanessa , Tadini Valentina , Sidiropoulos Páris NM , Wessig Carsten , Toyka Klaus V , Suter Ueli
Published: January 2019

Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesicular trafficking. Here, we genetically ablated Dnm2 in Schwann cells (SCs) and in oligodendrocytes of mice. Dnm2 deletion in developing SCs resulted in severely impaired axonal sorting and myelination onset. Induced Dnm2 deletion in adult SCs caused a rapidly-developing peripheral neuropathy with abundant demyelination. In both experimental settings, mutant SCs underwent prominent cell death, at least partially due to cytokinesis failure. Strikingly, when Dnm2 was deleted in adult SCs, non-recombined SCs still expressing DNM2 were able to remyelinate fast and efficiently, accompanied by neuropathy remission. These findings reveal a remarkable self-healing capability of peripheral nerves that are affected by SC loss. In the central nervous system, however, we found no major defects upon Dnm2 deletion in oligodendrocytes.
Molecular basis of wax-based color change and UV reflection in dragonflies
Authors: Futahashi Ryo , Yamahama Yumi , Kawaguchi Migaku , Mori Naoki , Ishii Daisuke , Okude Genta , Hirai Yuji , Kawahara-Miki Ryouka , Yoshitake Kazutoshi , Yajima Shunsuke , Hariyama Takahiko , Fukatsu Takema
Published: January 2019

Many animals change their body color for visual signaling and environmental adaptation. Some dragonflies show wax-based color change and ultraviolet (UV) reflection, but the biochemical properties underlying the phenomena are totally unknown. Here we investigated the UV-reflective abdominal wax of dragonflies, thereby identifying very long-chain methyl ketones and aldehydes as unique and major wax components. Little wax was detected on young adults, but dense wax secretion was found mainly on the dorsal abdomen of mature males of Orthetrum albistylum and O. melania, and pruinose wax secretion was identified on the ventral abdomen of mature females of O. albistylum and Sympetrum darwinianum. Comparative transcriptomics demonstrated drastic upregulation of the ELOVL17 gene, a member of the fatty acid elongase gene family, whose expression reflected the distribution of very long-chain methyl ketones. Synthetic 2-pentacosanone, the major component of dragonfly’s wax, spontaneously formed light-scattering scale-like fine structures with strong UV reflection, suggesting its potential utility for biomimetics.
USING ABSOLUTE PROBABILITY JUDGEMENT METHOD FOR HUMAN RELIABILITY ASSESSMENT - A CASE STUDY
Authors: Stojiljković Evica , Bijelić Bojan , Cvetković Marko
Published: January 2019

Human reliability assessment is becoming increasingly important in risk assessment in all industrial systems. All methods for human reliability assessment are used to estimate human error probabilities, which is a measure of human reliability. Human error assessment is certainly a challenge fo r all the experts involved in risk assessment today. In Serbia, this issue has not received proper attention yet. Therefore, this paper presents the case study which confirmed that the usage of Absolute Probability Judgement for proper human reliability assessment. This approach was used in a case study of the Electric Power Company in Serbia (hereinafter EPCS) for the purpose of the analysis accident of a repair intervention on a 10/0.4 kV steel lattice tower “Nova Kolonija” (jurisdiction of EPCS, Veliki Trnovac, ED “Jugoistok”, Nis, Serbia). The case study performed at the EPCS has confirmed that the conventional APJ approach is not only highly applicable for quantification of human errors, but also comprehensive and simple to use in risk assessment of complex systems. Key words: Absolute Probability Judgement, Human Reliability Assessment, Accident, Case Study
PSYCHOSOCIAL RISK MANAGEMENT
Authors: Živković Snežana , Milenović Miodrag , Rakić Tomislav
Published: January 2019

Nowadays, risk is considered to be a serious economic,
public and political problem. Professional risk and work-related
stress have the potential to negatively affect an individual
psychological and physical health, as well as an organisational
effectiveness. Psychosocial risks as a likelihood that work-related
psychosocial hazards will have a negative impact on employees’
health and safety through their perceptions and experience have been
identified as one of the major contemporary challenges for
occupational safety and health. Psychosocial risk management is
based on the principles of prevention and aims at risk elimination or reduction.
Key words: psychosocial risk, management, preventive measures, risk
assessment, stress
Influence of light intensity, fertilizing and season on the cirsiliol content, a chemical marker ofLeonotis nepetifolia(Lamiaceae)
Authors: de Oliveira Ana Paula , Borges Ivanildo Viana , Pereira Emanuella Chiara Valença , Feitosa Thiala Alves , dos Santos Raira Feitosa , de Oliveira-Junior Raimundo Gonçalves , Rolim Larissa Araújo , Cordeiro Viana Lucas Gustavo Ferreira , Ribeiro Luciano Augusto de Araújo , Santos Alan Diego da Conceição , Rolim-Neto Pedro José , Almeida Jackson Roberto Guedes da Silva
Published: January 2019

Background

Leonotis nepetifolia(Family Lamiaceae) is a medicinal plant from which the flavonoid cirsiliol with sedative, hypnotic, anti-inflammatory and cytotoxic activity has been extracted.

Methods

Seedlings were cultivated under different levels of shade in native or fertilized modes. The content of cirsiliol was measured monthly by high-performance liquid chromatography and the total phenolic content by the Folin-Ciocalteu method. Monitoring of growth was carried out with the weekly measurement of height until the stabilization of growth.

Results

The application of fertilizing and/or shading does not alter significantly the cirsiliol content. However, this content varies throughout the year, reaching the peak production in the summer, independently of the treatment applied. This same profile, with production in the summer, was also verified for phenolic compounds, reaching 58.15 ± 9.35 mg of equivalents of gallic acid per g of extract in the summer, content 1.84 times greater than the content verified in winter (31.56 ± 4.09 mg of gallic acid/g of extract). Although shading and fertilizing had no effect on cirsiliol content, the results also showed a positive influence on the height and biomass of the plant, which can causes a higher yield of extractable material.

Discussion

Biotic and abiotic stresses are able to increase or decrease the production of secondary metabolites, including phenolic compounds in medicinal plants and, as the stress response is peculiar to each species, cultivation studies become necessary. The present study reports by the first time the influence of shading, fertilizing and seasons in cirsiliol content inL. nepetifolia. Among analyzed variables, the seasons showed a larger influence in expression of cirsiliol and among seasons, our results showed that the summer is the ideal season for collections. In summer, the photoperiod is larger than in other seasons of the year and due to that, the plants need greater protection against the long photoperiod. For this, the plants increase the production of phenolic compounds as observed in this study. Although they do not influence the production of cirsiliol, the shading and nutrients in soil favor growth and leaf area of several plants, explaining, thus, the higher height and biomass obtained.
TGF-beta signalling in bovine mammary gland involution and a comparative assessment of MAC-T and BME-UV1 cells as in vitro models for its study
Authors: Mitz Charlotte Alexandra , Viloria-Petit Alicia Mercedes
Published: January 2019

The goal of the dairy industry is ultimately to increase lactation persistency, which is the length of time during which peak milk yield is sustained. Lactation persistency is determined by the balance of cell apoptosis and cell proliferation; when the balance is skewed toward the latter, this results in greater persistency. Thus, we can potentially increase milk production in dairy cows through manipulating apoptogenic and antiproliferative cellular signaling that occurs in the bovine mammary gland. Transforming growth factor beta 1 (TGFβ1) is an antiproliferative and apoptogenic cytokine that is upregulated during bovine mammary gland involution. Here, we discuss possible applications of TGFβ1 signaling for the purposes of increasing lactation persistency. We also compare the features of mammary alveolar cells expressing SV-40 large T antigen (MAC-T) and bovine mammary epithelial cells-clone UV1 (BME-UV1) cells, two extensively used bovine mammary epithelial cell lines, to assess their appropriateness for the study of TGFβ1 signaling. TGFβ1 induces apoptosis and arrests cell growth in BME-UV1 cells, and this was reported to involve suppression of the somatotropic axis. Conversely, there is no proof that exogenous TGFβ1 induces apoptosis of MAC-T cells. In addition to TGFβ1’s different effects on apoptosis in these cell lines, hormones and growth factors have distinct effects on TGFβ1 secretion and synthesis in MAC-T and BME-UV1 cells as well. MAC-T and BME-UV1 cells may behave differently in response to TGFβ1 due to their contrasting phenotypes; MAC-T cells have a profile indicative of both myoepithelial and luminal populations, while the BME-UV1 cells exclusively contain a luminal-like profile. Depending on the nature of the research question, the use of these cell lines as models to study TGFβ1 signaling should be carefully tailored to the questions asked.
The sinemydid turtleOrdosemysfrom the Lower Cretaceous Mengyin Formation of Shandong, China and its implication for the age of the Luohandong Formation of the Ordos Basin
Authors: Li Da-Qing , Zhou Chang-Fu , Li Lan , Yang Jing-Tao , Li Longfeng , Rabi Márton
Published: January 2019

Chronostratigraphic correlation of terrestrial Early Cretaceous biotas in China is highly problematic due to the lack of marine deposits, few absolute dates, and limited number of index fossils. This often leaves vertebrate faunas as one of the few potential tools for a preliminary biostratigraphy. Taxonomic identity of fragmentary fossils is, however, often uncertain and many faunas are insufficiently sampled. Turtles are one of the most common elements of Early Cretaceous biotas of Asia and their skeleton is frequently preserved more completely than that of other vertebrates- they yet receive little attention from vertebrate paleontologists. We here record the presence of the sinemydid turtleOrdosemys leiosfrom the Lower Cretaceous Mengyin Formation of Shandong Province, China, best known for the first dinosaurs and Mesozoic turtles described from the country.Ordosemysis the third turtle reported from the Mengyin Formation along withSinemys lensandSinochelys applanataand the only other formation whereOrdosemysis known to co-occur withSinemysis the Luohandong Formation of the Ordos Basin (Inner Mongolia), the type and so far only horizon ofOrdosemys leios. The presence of the crocodyliformShantungosuchusmay further define a fauna that is so far only known from these two formations. The stratigraphic position of the Luohandong Formation is poorly controlled and it has been placed anywhere between the Valanginian and Aptian. Published absolute dates from the Mengyin Formation and the numerous shared vertebrate and invertebrate taxa (now also including turtles) implies a Valanginian—early Hauterivian age for the Luohandong Formation—in contrast to late Hauterivian-Albian as previously proposed using the temporal distribution ofPsittacosaurus. The new specimen ofOrdosemys leiospreserves the only known manus of this species and ecomorphological analysis of limb proportions implies that it was a less capable swimmer compared toOrdosemys liaoxiensiscoming from the younger Jehol Biota.