bluuebunny/crossref_metadata_2025 huggingface dataset:
Probabilistic projections and past trends of sea level rise in Finland
Authors: Pellikka Havu , Johansson Milla M. , Nordman Maaria , Ruosteenoja Kimmo
Published: October 2022

Abstract. We explore past trends and future projections of mean sea level (MSL) on the Finnish coast, in the northeastern Baltic Sea, in 1901-2100. We decompose the relative MSL change into three components: regional sea level rise (SLR), postglacial land uplift, and the effect of changes in wind climate. Past trends of regional SLR can be calculated after subtracting the other two components from the MSL trends observed by tide gauges, as the land uplift rates obtained from the semi-empirical model NKG2016LU are independent of tide gauge observations. According to the results, local absolute SLR trends are close to global mean rates. To construct future projections, we combine an ensemble of global SLR projections in a probabilistic framework. In addition, we use climate model results to estimate future changes in wind climate and their effect on MSL in the semi-enclosed Baltic Sea. This yields probability distributions of MSL change for three scenarios representing different future emission pathways. Spatial variations in the MSL projections result primarily from different local land uplift rates: under the medium emission scenario RCP4.5/SSP2-4.5, for example, the projected MSL change (5 to 95 % range) over the 21st century varies from -28 (-54 to 24) cm in the Bothnian Bay to 31 (5 to 83) cm in the eastern Gulf of Finland.
How to mitigate flood events similar to the 1979 catastrophic floods in lower Tagus
Authors: Fernández-Nóvoa Diego , Ramos Alexandre M. , González-Cao José , García-Feal Orlando , Catita Cristina , Gómez-Gesteira Moncho , Trigo Ricardo M.
Published: October 2022

Abstract. The floods that struck lower Tagus valley in February 1979 correspond to the most intense floods in this river and affected the largest number of people in a river flow event in Portugal, during the last 150 years. In fact, the vast area affected impacted significantly circa 10k people in the lower Tagus sector (and an additional 7k in other regions of Portugal), including thousands of people evacuated or made homeless. In this context, the present study focuses on an in depth analysis of this event from a hydrodynamic perspective by means of Iber+ numerical model and on developing strategies to mitigate the flood episodes that occur in the lower section of the Tagus river using the outstating floods of February 1979 as benchmark. In this sense, several large dams and reservoirs are located along the Tagus river basin, and for that, dam operating strategies were developed and analyzed to take advantage of these infrastructures to minimize the effect of floods. Overall, the numerical results indicate a good agreement with water marks and some descriptions of the 1979 flood event, which demonstrates the model capability to evaluate floods in the area under study. Regarding flood mitigation, obtained results indicate that the frequency of floods can be reduced with the proposed strategies. In addition, hydraulic simulations corroborated an important decrease in water depth and velocity for the most extreme flood events, and also a certain reduction of flood extension was detected. This confirms the effectiveness of the proposed strategies to help in reducing flood impact in lower Tagus valley through the efficient functioning of dams.
Partitioning the contributions of dependent offshore forcing conditions in the probabilistic assessment of future coastal flooding
Authors: Rohmer Jeremy , Idier Deborah , Thieblemont Remi , Le Cozannet Goneri , Bachoc François
Published: October 2022

Abstract. Getting a deep insight into the role of coastal flooding drivers is of great interest for the planning of adaptation strategies for future climate
conditions. Using global sensitivity analysis, we aim to measure the contributions of the offshore forcing conditions (wave–wind characteristics,
still water level and sea level rise (SLR) projected up to 2200) to the occurrence of a flooding event at Gâvres town on the French
Atlantic coast in a macrotidal environment. This procedure faces, however, two major difficulties, namely (1) the high computational time costs of
the hydrodynamic numerical simulations and (2) the statistical dependence between the forcing conditions. By applying a Monte Carlo-based approach
combined with multivariate extreme value analysis, our study proposes a procedure to overcome both difficulties by calculating sensitivity measures
dedicated to dependent input variables (named Shapley effects) using Gaussian process (GP) metamodels. On this basis, our results show the
increasing influence of SLR over time and a small-to-moderate contribution of wave–wind characteristics or even negligible importance in
the very long term (beyond 2100). These results were discussed in relation to our modelling choices, in particular the climate change scenario, as
well as the uncertainties of the estimation procedure (Monte Carlo sampling and GP error).
Using a hybrid optimal interpolation–ensemble Kalman filter for the Canadian Precipitation Analysis
Authors: Khedhaouiria Dikraa , Bélair Stéphane , Fortin Vincent , Roy Guy , Lespinas Franck
Published: October 2022

Abstract. Several data assimilation (DA) approaches exist to generate consistent and continuous precipitation fields valuable for hydrometeorological applications and land data assimilation. Usually, DA is based on either static or dynamic approaches. Static methods rely on deterministic forecasts to estimate background error covariance matrices, whereas dynamic approaches use ensemble forecasts. Associating the two methods is known as hybrid DA, and it has proven beneficial for different applications as it combines the advantages of both approaches. The present study intends to explore hybrid DA for the 6 h Canadian Precipitation Analysis (CaPA). Based on optimal interpolation (OI), CaPA blends forecasts and observations from surface stations and ground-based radar datasets to provide precipitation fields over the North American domain. The application of hybrid DA to CaPA consisted of finding the optimal linear combination between (i) an OI based on the Regional Deterministic Prediction System (RDPS) and (ii) an ensemble Kalman filter (EnKF) based on the 20-member Regional Ensemble Prediction System (REPS). The results confirmed the known effectiveness of the hybrid approach when low-density observation networks are assimilated. Indeed, the experiments conducted for the summer without radar datasets and for the winter (characterized by very few observations in CaPA) showed that attributing a relatively high weight to the EnKF (50 % and 70 % for summer and winter, respectively) resulted in better analysis skill and a reduction in false alarms compared with the OI method. A deterioration in the moderate- to high-intensity precipitation bias was, however, observed during summer. Reducing the weight attributed to the EnKF to 30 % alleviated the bias deterioration while improving skill compared with the OI-based CaPA.
Training and Development in Human Resources Management
Authors: Öztırak Mesut
Published: October 2022

Education as a general definition; in the behavior of the individual through his own life it is the process of bringing about desired changes. Teaching, planned and planned education carried out in a certain place and in a time period called the programmatic part. Based on these definitions, my concept of education is more we can say that it is comprehensive. Development, employment in the organization to increase the performance of the employee. Made by the management during the period from the start of the it includes all efforts related to activities. Training and development in organizations or businesses involving employees activities have a number of purposes. These; to achieve high efficiency at an affordable cost, to increase the quality of goods and services for production, to prevent waste of materials, raw materials and energy, to help the organization in effective time management, to increase the level of organizational commitment by providing motivation and job satisfaction of employees can be counted as increasing and strengthening the corporate culture. In this study, the training and development function in human resources management is mentioned. Key words: Human Resources Management, Training, Development, Training and Development Jel Code: M10, M11
Factors Affecting Family Welfare of Garut-Indonesia Flash Flood Survivors: A Case Study of Impact Disaster on SDGs
Authors: Sunarti Euis , Johan Irni Rahmayani , Rosullih Mullina , Sholikhah Nur Faizatus
Published: October 2022

Disasters risk reduction and sustainable development goals (SDGs) are closely linked. The frequent disaster causing devastating impact on society and community. This study aims to analyze the driver of family welfare of survivors of the 2016 Garut flash flood. The total sample consisted of 120 families, some living in temporary sheltered evacuation sites (SF) and others having returned home (non-sheltered group/NSF). Data was obtained at the four months following the disaster. The study revealed that, compared to the respondents in the SF sites, the NSF respondents had higher income, more sources of stress, better coping strategies, and a higher level of welfare. Income, financial management, coping strategies, and economic pressure all had a positive effect on total welfare while, in the case of subjective wellbeing, greater impact came from sources of stress compared with coping strategies. Objective wellbeing, on the other hand, was only influenced by income and coping strategies.
Stereological examination of the effect on the hippocampal dentate gyrus granule cells number of rats subjected to wireless internet during prenatal period: a preliminary study
Authors: RAGBETLİ Murat Çetin , ÖZALPER Büşranur , CAKİR Tahir
Published: October 2022

As a result of industrialisation and the many recent advances in technology, we are being intensely subjected to non-ionised radiation sources. As such, the effect of non-ionised radiation on human tissue is now being researched. In this study, the effects of Wi-Fi waves found in some third-generation mobile phones to facilitate internet connection on the brain hippocampal dentate gyrus granule cell quantity of rats during the prenatal period was stereologically examined. During the study, mated albino rats were subjected to Wi-Fi throughout pregnancy. A month after giving birth, six rats from each group, for a total of 12 rats, was sacrificed under perfusion and anaesthesia. Their skulls were opened and brains were removed to undergo routine checks in which the granule cells were counted. Strategic sections were defined, and every 45th section couple (with a thickness of 5 μm) was taken and dyed with haematoxylin and eosin (H&E) and cresyl violet stain. The granule cells were counted using a combination of the stereological disector method and Cavalieri’s principle. Then, the results were analysed using the Mann–Whitney U test. No statistically significant difference has been observed between the groups (p > 0.05). The findings were discussed in light of the relevant literature, and it was determined that throughout pregnancy, Wi-Fi modem device did not result in any changes in the dentate gyrus granule cell count of the hippocampus of postnatal rats’ brains.
Efficacy of combining clinical crown lengthening surgery and botulinum toxin A injection in gummy smile treatment
Authors: Ho Viet Tran , Nguyen Hao Trong , Dien Vu Hoa Anh , Nguyen-Ho Anh Quynh , Nguyen Hien Thi Minh , Huynh Nam Cong-Nhat , Nguyen Thuy Thu
Published: October 2022

In many cases, the cause of a gummy smile is a combination of many simultaneously occurring factors. Therefore, a single method is certainly not effective in achieving the maximum aesthetic requirements. This study aims to evaluate the efficacy of combining clinical tooth crown lengthening surgery and subsequent BTX-A injection in gummy smile treatment using clinical and photographical assessment. 21 patients with an average length of excessive gingival display of at least 4 mm at maximum smiling point and with the height of keratinized gingiva ≥ 3 mm were recruited. Gingival exposure (GE) and clinical crown length (CCL) were measured at baseline (T0), two months after clinical crown lengthening surgery (T1), two weeks after BTX-A injection (T2), two months after BTX-A injection (T3). GE values at T1, T2 and T3 were significantly different (p <0.001). CCL was significantly changed after gingivectomy surgery (T1) compared to preoperative value (T0) (p <0.001). BTX-A could be considered a favorable adjunctive treatment for gummy smile patients after gingivectomy surgery.
Comparison of liver biomarkers with N/L ratio, CRP, d-dimer in Covid 19 pneumonia and its effect on mortality
Authors: HAYDAR Fadime Güllü , OTAL Yavuz , AVCIOĞLU Gamze
Published: October 2022

Coronavirus Disease-2019 (Covid-19) is the cause of a pandemic that has high mortality and global effects. The liver damage in Covid-19 cases in mechanical ventilation was investigated in this study. A total of 60 patients (the Study Group) who were diagnosed with Covid-19 pneumonia, and 65 individuals (the Control Group) were included prospectively in the study. The cases were divided into 3 groups as those who were intubated (severe), those who were not intubated (mild), and the healthy Control Group. The lung tomography results of those who were diagnosed with Covid-19 were examined in the study. The cases with positive RT-PCR (Real Time Polymerized Chain Reaction) test results were recorded from the system. The liver tests of the patients were compared with those of the Control Group. The two groups with and without intubation were also compared. The results were evaluated and analyzed statistically. When all the data were evaluated, it was found that LDH, GGT, AST, and aPTT levels were significantly higher in the mild and severe patient group compared to the Control Group, and the T. Protein and albumin levels were low (p<0.01). The N/L Ratio, and the CRP levels, which are the other acute phase reactants, were significantly higher (p<0.05). No statistically significant differences were detected when all parameters of the groups with and without intubation were compared (p>0.05). Increased D-dimer, GGT, D. Bil, LDH, NLR, and AST levels in Covid-19 patients in invasive mechanical ventilation are associated with mortality.
Psychological reactions of different affective temperaments to the COVID-19 pandemic
Authors: KEFELİ Mehmet Celal , ŞANLI Esat
Published: October 2022

Various studies show that the temperament characteristics of individuals play a decisive role in how much and how they will be affected by traumatic events. However, no research has been found in the literature examining the relationship between affective temperament and trauma. The Covid 19 pandemic process is described as a social trauma. In this context, in this study, it is aimed to examine the reactions of different affective temperaments to social trauma within the framework of the pandemic. Within the scope of the research, the Depression, Anxiety and Stress Scale (DASS-21) and Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionaire (TEMPS-A) were used. The scales were applied online to a total of 1075 volunteer participants (653 women and 422 men). Multiple regression analysis was conducted to determine the significance of temperament types in the prediction of depression, anxiety, and stress levels of individuals. The method employed was stepwise regression analysis. In the data obtained, it was observed that depression, anxiety, and stress levels and anxious, cyclothymic, depressive, and irritable temperament types showed a positive correlation at different levels and a low level of negative correlation with hyperthymic temperament type during the pandemic process. The four aforementioned affective temperament types were significant predictors for depression, three were predictors for stress, and two for anxiety. Additionally, the results of this study indicated that hyperthymic temperament can be protective against the effects of trauma.
The efficacy of computed tomography-guided percutaneous microwave ablation in patients with osteoid osteoma according to nidus location in long bones: A single-centre initial experience
Authors: ÖZBALCI Aysu Başak , DABAK Nevzat
Published: October 2022

This study aims to assess the efficacy of microwave ablation (MWA) treatment in painful extra-articular osteoid osteoma (OO) in long bones in a consecutive series of patients and to compare the technical and clinical success in terms of pain scores according to their location. A total of 23 patients who were diagnosed with OO in long bones and treated with MWA between January 1, 2016, and June 1, 2020 were enrolled in this study. Medical data and images were reviewed for age, gender, size of the nidus and duration of pain. Patients were then categorized into three groups according to the location of nidus (pertrochanteric, metaphyseal or diaphyseal). Operation length and technical and clinical success rates were compared. Technical success was achieved in 100% of patients. Primary clinical success following MWA was 82.6%. The most common location was the pertrochanteric region (34.8%). In comparing the pain scores with the locations of the lesions, no statistically significant difference was found between the first-day (p = 0.504) and first-week (p = 0.648). However, significant difference was present between the first month (p = 0.016), third month (p < 0.001) and sixth month (p = 0.001). The statistically significant differences between the sites were due to the difference between the pertrochanteric and diaphyseal lesions. CT-guided percutaneous MWA is safe and effective in the treatment of OO located in long bones without any recurrence. However, management of pertrochanteric OOs requires specific expertise and follow up. Further studies are expected in the future to assess the long-term efficacy and safety of MWA for the treatment of OO, especially for cases in pertrochanteric locations of the femur, which have an increased risk of local recurrence.
Evaluation of ovarian reserve at late reproductive age
Authors: KULAKSIZ Deniz , ERİN Recep
Published: October 2022

Although follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), antimullerian hormone (AMH), and ovarian volume are commonly used to assess ovarian reserve and ovarian response to stimulation, no test directly indicates this. We aimed to observe how ovarian reserve tests help us in the diagnosis and treatment of women of late reproductive age. We included 190 patients in this prospective cohort study. We took FSH, LH, E2 and AMH blood samples on the third day of menstruation to biochemically evaluate the ovarian reserve of the patients who were planned for hysterectomy and bilateral salpingo-oopherectomy at late reproductive age. We recorded antral follicle counts (AFC) and ovarian volumes by transvaginal ultrasonography for ultrasonographic evaluation and weighed ovarian weights postoperatively. The data of 190 women aged 39-44.9 years revealed that AMH and ovarian volume, ovarian volume and AFS show significant positive correlations, whereas FSH, LH, and E2 levels do not indicate a significant relationship with AFS. AMH, ovarian volume and ovarian weight, and AFC may show us the ovarian reserve with the highest reliability in women of late reproductive age.
Evaluation of factors affecting the development of re-operation due to hemorrhage after lung resection
Authors: ÖZGÜR Yücel , AKER Cemal
Published: October 2022

In our study, preoperative factors affecting the development of re-operation after lung resection were examined.413 patients who underwent lung resection between 2018-2020 were included in our study. The preoperative data of 25 (6.1%) patients who underwent re-operation and 388 (93.9%) patients who did not undergo re-operation were compared. Preoperative hemoglobin level (p=0.009), neoadjuvant therapy (p<0.001), pneumonectomy (p<0.001), thoracotomy (p=0.005), amount of intraoperative blood loss (p<0.001), need for intraoperative blood product use (p). =0.005), intraoperative mean arterial pressure (p=0.01), pulse rate (p=0.001), postoperative hemoglobulin amount (p<0.001) were found to affect and increase the probability of re-operation. It was statistically significant that the need for postoperative blood product usage was higher (p<0.001), postoperative complications (100% vs. 22.8%, p<0.001) and mortality (0.6% vs. 4%, p=0.01) in reoperated patients. It was found that the hospitalization day in the ICU was longer in those who underwent reoperation than in those who did not (3.2 days vs. 1.5, p<0.001). Independent risk factors affecting re-operation according to multiple logistic regression analysis; neoadjuvant treatment (p<0.001), operation time (p=0.04), intraoperative pulse rate (p=0.01) and postoperative hemoglobin (p<0.001) were found. Low preoperative hemoglobin level, on the other hand, independently affected the development of re-operation at a level close to significance (p=0.06). Re-operation due to bleeding after lung resection increases the rate of cardiopulmonary complications in the postoperative period. Careful follow-up and approach of surgery and anesthesia in the intraoperative period will contribute to the decrease in the incidence of re-operation.
The effects of body weight and pneumoperitoneum on pleth variability index and total haemoglobin in patients undergoing laparoscopic cholecystectomy: A prospective observational study
Authors: PATMANO Gülçin , PATMANO Mehmet , GÜMÜŞ Tufan , KILINÇ Mikail
Published: October 2022

It is not clear if there is an inaccurate effect of obesity and pneumoperitoneum on non-invasive monitoring parameters. The aim of this study is to determine the effects of CO2 pneumoperitoneum and desufflation on non-invasive monitoring variables between obese and non-obese patients undergoing laparoscopic surgery. Sixty patients were included in the study that underwent laparoscopic cholecystectomy between February 2019 and November 2019. After induction of anaesthesia, systolic and diastolic blood pressures, heart rate, duration of operation and pneumoperitoneum, pleth variability index (PVI) and total hemoglobin (SpHb) data were recorded. The patients were divided into two groups. There was no significant difference between the groups in terms of chronic diseases and duration of operation and pneumoperitoneum. No significant difference was found between the groups in PVI and SpHb values. In comparison of PVI measurement values with T0, a significant difference was found in T3, T4 and T5 in Group 2 (p = 0.010, 0.012 and 0.041, respectively). In comparison of SpHb measurement values with T0, a significant difference was found in T1, T2 and T3 in Group 2 (p = 0.008, 0.010 and 0.037, respectively). In comparison with T5, a significant difference was found in T1, T2 and T3 in Group 2 (p = 0.023, 0.005 and 0.006, respectively). In obese people, pneumoperitoneum can lead to errors in PVI and SpHb monitoring. Although these two parameters are very valuable in intraoperative follow-up, they should be used carefully during laparoscopic procedures in obese patients. If these parameters (PVI and SpHb) are considered to be used in bariatric surgeries, this information should be considered.
The effect of iv tranexamic acid on blood loss during myomectomy
Authors: KALKAN Üzeyir , ÖLÇENOĞLU Mehmet , BAKAY Kadir
Published: October 2022

Uterine leiomyomas are benign gynecological tumors of the uterus which are commonly seen in women under 50 years of age and they are one of the common reasons of abnormal uterine bleeding. Myomectomy is the most common treatment method among women who want to remain fertile and/or to protect the uterus. Approximately 1-4% of myomectomy operations end up with hysterectomy due to uncontrollable bleeding. Many different methods are used in order to reduce the incidence of uncontrollable bleeding and minimize blood loss. In this study, we have examined the effect of intraoperative intravenous tranexamic acid on blood loss on type 3, 4, 5, and 6 myomas during myomectomy according to FIGO grading and its postoperative results.
The pivotal role of the number of transferred embryos in oocyte donation cycles: A retrospective cohort study
Authors: ÖNAL Murat , DOKUZEYLÜL GÜNGÖR Nur , GÜRBÜZ Tuğba , AYAR MADENLİ Asena
Published: October 2022

This research aimed to show the role of the number of transferred embryos on pregnancy outcomes of the oocyte donation cycles (ODC). This retrospective cohort study included 122 ODCs performed at a private in vitro fertilization (IVF) center between 2020 June - 2021 January. Cases with severe male infertility, tuboperitoneal, and endometrial factors were not included in the study. The median (interquartile range) recipient age was 43 (30–54) years. ODC results revealed that 10.7% of the cases were negative, 4.9% were biochemical pregnancies, and 84.4% were clinical pregnancies. Pregnancy outcomes were checked; miscarriage, preterm, and term delivery rates were 5.7%, 3.9%, and 90.4%, respectively. The rate of recipients for the younger than 40 years was 32%, between the 40–44 years was 27%, and between 45–54 years was 41% respectively. Statistically significant difference was not observed between age groups in terms of endometrial thickness (p = 0.059), number of transferred embryos (p = 0.857), number of ODC attempt (p = 0.666), live birth rate (p = 0.1), and other pregnancy outcomes (p > 0.05, for all). A total of 96 (78.7%) embryo transfers (ET) resulted in a live birth. In 8.2% (n=10) of cases, single embryo transfer (SET) and in 91.8% (n=112) of cases, double embryo transfer (DET) was performed. The number of embryos transferred was statistically significantly higher among cases that resulted in live births compared to cases without live births (p = 0.002). Significant difference was not found in terms of the recipient age (p = 0.392), male age (p = 0.108), endometrial thickness (p = 0.478), and the number of attempt (p = 0.777) between cases resulted in live birth or not. The only parameter that affects the live birth rates in ODC is the number of transferred embryos.
Surgical treatment of basket impaction, a rare complication of ERCP. Single centre experience
Authors: KARABULUT Kağan , GÖREN İbrahim
Published: October 2022

Basket impaction is a rare complication of Endoscopic Retrograde Cholangiopancreatography (ERCP). This complication is usually treated non- operatively. Surgery is required when non-operative methods fail. In this study, we retrospectively evaluated the results of five patients who underwent surgery for basket impaction between January 2017 and December 2021. The median mean age was 50 (21-82) years. Basket impaction was in the common bile duct in three patients and the pancreatic duct in two. There was no operative complication. Wound infection developed in one patient and evisceration in one in the postoperative period. The length of hospital stay was 10 (7-12) days. The overall morbidity rate was 33.3%. There was no postoperative mortality. Basket impaction can usually be treated with non-operative interventions. Surgical intervention should be preferred last.
Maternal-fetal characteristics, etiological factors and perinatal outcome in pregnancies with polyhydramnios
Authors: ÖZDEMİR Özge , BOLLUK Gökhan , ÇOBAN Ulaş , KURT Kübra
Published: October 2022

Basket impaction is a rare complication of Endoscopic Retrograde Cholangiopancreatography (ERCP). This complication is usually treated non- operatively. Surgery is required when non-operative methods fail. In this study, we retrospectively evaluated the results of five patients who underwent surgery for basket impaction between January 2017 and December 2021. The median mean age was 50 (21-82) years. Basket impaction was in the common bile duct in three patients and the pancreatic duct in two. There was no operative complication. Wound infection developed in one patient and evisceration in one in the postoperative period. The length of hospital stay was 10 (7-12) days. The overall morbidity rate was 33.3%. There was no postoperative mortality. Basket impaction can usually be treated with non-operative interventions. Surgical intervention should be preferred last.
Investigation of the changes in the general characteristics of COVID19 patients with the vaccination program
Authors: OKUŞ Oktay , HAKOĞLU Onur , SEZİK Savaş , KAYHAN ÖMEROĞLU Şeyda
Published: October 2022

Since the onset of the Coronavirus Disease 2019 (COVID-19) pandemic, many vaccine research studies have started. Changes in the demographic characteristics of the patients hospitalized from the emergency room to the intensive care unit due to COVID-19 has caught our attention since the vaccination program began in Turkey. The purpose of this study is to investigate whether our investigation is scientifically valid and meaningful. Thus, it will be helpful to investigate the effect of priority ordering in vaccination programs in future pandemics. Demographic characteristics and hospitalization processes of patients hospitalized in the intensive care unit before and after vaccination were compared. For comparison, Charlson Comorbidity Index (CCI) and Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) scores, as well as intensive care unit duration of stay and mortality were used. While age [mean (SD); 70,8 (12,2) vs 66,2 (15,2), p=0,032] and duration of intensive care stay [day; mean (SD); 6,4 (6,3) vs 9,4 (7,4); p<0,001] increased in the post-vaccination group, a statistically significant decrease was observed in APACHE [mean (SD); 26,9 (9,2) vs 20,9 (9,0); p=0,008] and CCI scores [mean (SD); 4,3 (2,2) vs 3,6 (2,7); p<0,001]. Regulating the priorities of those to be vaccinated causes rapid changes in the patient population. For this reason, vaccination of vulnerable groups will contribute to the operation of the health system properly.
Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats
Authors: DARAKCI SALTIK Özge , ARSLAN Gökhan , AĞAR Erdal , BOZKURT Ayhan
Published: October 2022

Cannabinoid receptor-1 (CB1R) and cannabinoid receptor-2 (CB2R) have significant roles in the esophagus, small intestine, and colon motility in the postprandial period besides gastric emptying, secretion, and defecation in the gastrointestinal system. Furthermore, our previous study showed that activation of peripheral CB1R inhibited migrating myoelectric complex (MMC), forming the source of fasted small intestinal motility. However, the role of the central/peripheral CB2Rs on the MMC pattern is still unknown. The present study aimed to investigate the roles of peripheral and central CB2Rs in forming and regulating small intestine MMC patterns in rats. In this study, we used 42 adult male Sprague-Dawley rats (n:7). We implanted bipolar electrodes in three different jejunum sites of rats (J1, J2, J3) to record the MMC pattern. We placed a cannula in the right lateral ventricle to perform drug intracerebroventricularly (i.c.v.) and implanted a catheter in the right jugular vein to inject the drug intravenously (i.v). After the amelioration period, we conducted experiments following an 18-hour fasting period and later took at least a one-hour baseline recording of the MMC pattern. Then, we injected JWH 133, a CB2R agonist i.v. (1.25-10 mg/kg) or i.c.v. (2.5- 20 μg/rat) and also administered AM 630, a CB2R antagonist, i.v. (0.25-2 mg/kg) or i.c.v. (2.5-20 μg/rat). We compared the effects of JWH 133 or AM 630 on the MMC pattern to the vehicle group (10% dimethyl sulfoxide). Centrally or peripherally injected JWH 133 and AM 630 did not cause any change in the spike frequency and the number of the MMC cycle. The results of the present study propose that CB2Rs are involved in neither endogenous formation nor exogenous regulation of the fasting myoelectric activity in healthy fasted rats.
Predictive factors and importance of Critical View of Safety in difficult elective laparoscopic cholecystectomy
Authors: KAR Haldun , ATAY Arif
Published: October 2022

Knowing the surgical anatomy and related variations, revealing the factors that indicate difficult cholecystectomy, knowing and applying various safe surgical cholecystectomy techniques and guidelines recommended to prevent injuries can prevent complications. This study, it is aimed to evaluate the preoperative factors that will predict difficult elective cholecystectomy. We retrospectively analyzed the data of patients treated for cholelithiasis by an experienced hepatobiliary surgeon or under his supervision between March 2018 and March 2020. Clinical, laboratory, and imaging data obtained from patients' files were evaluated. According to the Modified Nassar Scale (MNS), 140 (79.5%) patients were considered grade 1-2 (easy) and 36 (20.5%) grade 3-5 (difficult) patients within the framework of intraoperative findings. Critical View of Safety was successfully performed in 170 (96.6%) of the patients. Converting laparoscopic cholecystectomy to open was performed in two (1.1%) patients who had an MNS of 4 and 5. The most common comorbidity was hypertension. Male gender, previous cholecystitis and ERCP, and increased gall bladder wall thickness from preoperative USG findings are independent risk factors for difficult cholecystectomy in patients scheduled for laparoscopic cholecystectomy. In addition, it should be kept in mind that LC can be difficult in patients with hypertension and coronary artery disease.
Mammalian cell lines used in bioprocessing
Authors: ERGEN Nuri , TÜFEKÇİ Halil
Published: October 2022

A various number of expressions and host systems are used in biologics manufacturing. The most commonly preferred systems are based on bacteria, yeast, mammalian cells, insect cells, and transgenic animals. A wide range of molecules, including insulin, mAbs, vaccines, and recombinant proteins, are produced using different host systems. Because of several reasons impacting the product quality and yield, mammalian cells are utilized. Moreover, mammalian cells are generally used in virus-based vaccine manufacturing. Chinese Hamster Ovary (CHO) is the most widely used cell line for high yield stable recombinant protein production, while Human Embryonic Kidney (HEK) is favoured for transient transfection low yield protein manufacturing, viral-based vaccine and gene and cell therapy-related vector production. Other mammalian cell lines such as NSO, Sp2.0, Vero, MRC-5 and PerC.6 are also used in both recombinant protein and virus productions. Multiple modifications are carried out on industrial cell lines to make them more suitable for high yield and high-quality protein production. Thanks to these alterations, high productivity and quality levels are achieved in the biotechnology industry.
MRI and pathology findings of a mass-like fat necrosis in the breast
Authors: ÇOLAKOĞLU Arda , POLAT Ahmet Veysel , SÜLLÜ Yurdanur , AKAN Hüseyin
Published: October 2022

Fat necrosis of the breast is a benign inflammatory process and, it has a wide range of findings on Magnetic Resonance Imaging (MRI), some of which are in the malignant spectrum. We present a case of a breast fat necrosis that mimicked malignancies on MRI because of the intense internal enhancement with a type 3 kinetic curve, its relatively large size, and axillary lymphadenopathy.
Kager’s sign; an underestimated radiographic feature in detecting acute Achilles tendon rupture: A report on two cases
Authors: OSOYDAN SATICI Merve , İSLAM Mehmet Muzaffer , AKSEL Gökhan , EROĞLU Serkan Emre
Published: October 2022

This research aimed to show the role of the number of transferred embryos on pregnancy outcomes of the oocyte donation cycles (ODC). This retrospective cohort study included 122 ODCs performed at a private in vitro fertilization (IVF) center between 2020 June - 2021 January. Cases with severe male infertility, tuboperitoneal, and endometrial factors were not included in the study. The median (interquartile range) recipient age was 43 (30–54) years. ODC results revealed that 10.7% of the cases were negative, 4.9% were biochemical pregnancies, and 84.4% were clinical pregnancies. Pregnancy outcomes were checked; miscarriage, preterm, and term delivery rates were 5.7%, 3.9%, and 90.4%, respectively. The rate of recipients for the younger than 40 years was 32%, between the 40–44 years was 27%, and between 45–54 years was 41% respectively. Statistically significant difference was not observed between age groups in terms of endometrial thickness (p = 0.059), number of transferred embryos (p = 0.857), number of ODC attempt (p = 0.666), live birth rate (p = 0.1), and other pregnancy outcomes (p > 0.05, for all). A total of 96 (78.7%) embryo transfers (ET) resulted in a live birth. In 8.2% (n=10) of cases, single embryo transfer (SET) and in 91.8% (n=112) of cases, double embryo transfer (DET) was performed. The number of embryos transferred was statistically significantly higher among cases that resulted in live births compared to cases without live births (p = 0.002). Significant difference was not found in terms of the recipient age (p = 0.392), male age (p = 0.108), endometrial thickness (p = 0.478), and the number of attempt (p = 0.777) between cases resulted in live birth or not. The only parameter that affects the live birth rates in ODC is the number of transferred embryos.
Evaluation of the presence of reinfection in patients presenting to the emergency department with COVID-19 symptoms after recovery
Authors: ÖZDEMİR Serdar , TUNCER KARA Kevser , AKÇA Hatice Şeyma
Published: October 2022

This study aimed to evaluate COVID-19 reinfection in patients that presented to the emergency department with similar or different COVID-19 symptoms after recovery from the disease. This retrospective study included patients aged over 18 years presenting to the emergency department between January 1, 2021 and July 1, 2021, who had been previously diagnosed with COVID-19 and received treatment for the disease. Statistical analysis was performed using SPSS version 22.0.A total of 199 patients, 54.3% female, were included in the study. PCR positivity was present in 2.5% of the patients, and it was statistically significantly low(p<0.001). The most common symptom was fatigue (46.2%), and the least common symptom was loss of taste (3.0%). However, there was a statistically significant correlation between the loss of taste and smell and PCR positivity (p=0.024 and p=0.043, respectively). The logistic regression analysis revealed that the loss of taste and loss of smell alone did not have an effect on PCR positivity (p=0.848, 95% confidence interval: 0.005-71.83 and p=0.287, 95% confidence interval: 0.001-9.369). In the Covid-19 management and treatment guide, it is necessary to make changes in terms of symptoms for people who have had Covid-19 disease.
Adamkiewitz syndrome in Marfan syndrome and rehabilitation outcomes-3 cases and review of the literature
Authors: KIRAÇ ÜNAL Zeynep , ÇELİK Gülnur , YILDIZ Sadik Yiğit , CANKURTARAN Damla , ÜNLÜ AKYÜZ Ece , İNCE Ilker
Published: October 2022

Acute Spinal Cord Ischemia Syndrome (ASCIS) is rare but clinically significant. Aortic dissection (AD) is one reason for ischemia of the spinal cord. The artery of Adamkiewicz provides the major blood supply to the anterior thoracolumbar spinal cord, and injury to this artery can cause consequential neurologic damage.Three male patients applied to our rehabilitation clinic with paraplegia. All three had AD due to Marfan Syndrome and clinical findings due to Adamkiewitz artery ischemia. Although we later learned that one of the patients later died from a new ruptured aortic aneurysm, we achieved good motor gains in these rare cases with rehabilitation. Although paraplegia is rare as the initial symptom in AD, vascular etiology should not be forgotten in acute paraplegia. The prognosis of ASCIS is known to be poor, but a good and individualized rehabilitation program is required.
Efficacy and safety of platform myocardial stabilizer for off-pump coronary artery bypass grafting
Authors: ABDURAKHMANOV Abdusalom , OBEİD Mustapha
Published: October 2022

It is important to have methods and devices for stabilizing the beating heart that are capable of maintaining atraumatic interaction with the surface of the beating heart over a wider range of conditions and orientations. Therefore, the development of simple and safe surgical methods that provide a stable and bloodless coronary anastomotic field is important for the successful coronary artery bypass grafting with a beating heart. In this article, we have tried to show the safety of our stabilizer in experimental operations.
PENGARUH KOMUNIKASI TERHADAP KINERJA KARYAWAN DENGAN DIMEDIASI OLEH KEPUASAN KERJA DI CV. INSAN PRATAMA SURABAYA
Authors: Dinata Yudha Putra
Published: October 2022

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh komunikasi terhadap kepuasan kerja karyawan CV. Insan Pratama Surabaya, bagaimana pengaruh komunikasi terhadap kinerja karyawan CV. Insan Pratama Surabaya, bagaimana pengaruh kepuasan kerja terhadap kinerja karyawan CV. Insan Pratama Surabaya dan bagaimana pengaruh Komunikasi terhadap Kinerja Karyawan dengan dimediasi oleh Kepuasan Kerja CV. Insan Pratama Surabaya.

Penelitian ini dilakukan dengan pendekatan kuantitatif juga mengumpulkan dan menganalisis data, menggunakan strategi survei dan eksperimen, melakukan pengukuran dan observasi, serta pengujian teori dengan uji statistik. Berdasarkan rumusan masalah dan tujuan penelitian, maka jenis penelitian ini bersifat explanatory. Dalam penelitian ini menggunakan metode probabilitas sampling, sedangkan teknik pengambilan sampel menggunakan simple random sampling.

Hasil dari penelitian ini adalah Komunikasi berpengaruh positif secara langsung terhadap kepuasan kerja karyawan CV. Insan Pratama Surabaya,  komunikasi berpengaruh positif secara langsung terhadap kinerja karyawan CV. Insan Pratama Surabaya, kepuasan kerja berpengaruh positif secara langsung terhadap kinerja karyawan CV. Insan Pratama Surabaya dan peran kepuasan kerja memediasi komunikasi dan kinerja karyawan berpengaruh positif. Dengan demikian kepuasan kerja mampu memediasi komunikasi dan kinerja karyawan pada karyawan CV. Insan Pratama Surabaya.
Pemikiran Yuval Noah Harari Terhadap Ekonomi Uang Dan Ekonomi Agama
Authors: Ubaidillah Ahmad , Khoir Misbahul
Published: October 2022

Ilmu ekonomi adalah ilmu yang diciptakan oleh manusia untuk memenuhi kebutuhan yang semakin tidak terkendali. Begitu manusia menyadari betapa sedikit yang mereka ketahui tentang dunia, maka manusia memiliki alasan yang kuat untuk mencari pengetahuan baru, untuk membuka jalan bagi kemajuan sains. Tulisan ini mencoba mencari tahu pemikiran Yuval Noah Hariri dalam ekonomi. Pembahasan yang diajukan adalah tentang peran uang bagi manusia dan posisi ekonomi agama dalam isu ekonomi global. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah dokumentasi. Sedangkan teknik analisis yang digunakan adalah analisis isi. Hasil penelitian menunjukkan bahwa uang hanya memiliki nilai dalam imajinasi manusia. Nilainya tidak dalam struktur kimia atau warna atau dalam bentuk cangkang atau kertas. Dengan kata lain, uang bukanlah realitas material. Uang adalah produk psikologis. Uang bekerja dengan mengubah materi menjadi pikiran. Selain itu, Harari berpendapat bahwa tidak ada yang namanya “Ekonomi Kristen, Ekonomi Islam”, atau “ekonomi Hindu”. Bukannya tidak ada ide-ide ekonomi dalam Alkitab, Quran atau Veda. Hanya saja ide-ide tersebut tidak uptodate, tidak relevan dengan tantangan ekonomi modern. Teori-teori ekonomi modern jauh lebih relevan daripada dogma-dogma tradisional yang telah menjadi umum untuk menafsirkan bahkan konflik-konflik agama yang pura-pura dalam istilah ekonomi, sementara tidak ada yang berpikir sebaliknya
Pengaruh Cita Rasa Dan Promosi Terhadap Keputusan Pembelian Crispi Jamur Bobby’z di Desa Sukorejo Kecamatan Karangrejo Kabupaten Tulungagung
Authors: Masitoh Ruruh Dewi Sekar , Sri W H Maria Agatha
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh cita rasa dan promosi terhadap keputusan pembelian baik secara parsial maupun secara simultan pada Crispi Jamur Bobby’z Di Desa Sukorejo Kecamatan Karangrejo Kabupaten Tulungagung. Penelitian ini menggunakan pendekatan kuantitatif. Variabel dalam penelitian ini  adalah cita rasa (X1), promosi (X2) dan keputusan pembelian (Y). Populasi dalam penelitian ini adalah konsumen Crispi Jamur Bobby’z yang berjumlah 1.195 orang, dengan Jumlah sampel 180 konsumen,  teknik  pengambilan  sampel  yang  digunakan  adalah  teknik probability sampling yaitu menggunakan simpel random sampling.   Data   dikumpulkan   dengan menggunakan kuesioner. Teknik analisis data menggunakan regresi linier berganda dengan kriteria uji F dan uji t. Hasil penelitian menunjukkan bahwa cita rasa memiliki pengaruh positif terhadap keputusan pembelian. Hal ini didasarkan pada  hasil t-hitung pada variabel cita rasa sebesar 6,631 dengan  tingkat  signifikansi  sebesar  0,000.  Promosi  juga  berpengaruh positif terhadap keputusan pembelian. Hal ini  didasarkan pada hasil t-hitung pada variabel promosi sebesar 5,237 dengan tingkat signifikansi sebesar 0,000. Kemudian secara simultan cita rasa dan promosi juga berpengaruh  signifikan terhadap keputusan pembelian Crispi Jamur Bobby’z. Hal ini didasarkan  pada hasil penelitian yang dapat dilihat dari hasil F-hitung sebesar 51,151 dengan tingkat signifikansi kurang dari 5% yaitu 0,000.
PENINGKATAN RELIGIUSITAS DAN PENDAPATAN KELUARGA MELALUI EKONOMI KREATIF PADA IBU RUMAH TANGGA DAN GENERASI MUDA DIKAWASAN BEKAS KERATON KARTASURA
Authors: Nurohman Yulfan Arif , Kusuma Melia , Azhar Fahri Ali , Wicaksono Nur , Qurniawati Rina Sari
Published: October 2022

The area of the former Kartasura Palace has interesting tourism potential to be developed. One way to develop tourism potential is through the creative economy with the presence of special culinary delights that can increase interest in visiting the people of Solo and its surroundings. The potential of the community that can be developed in supporting a typical culinary business are housewives and the younger generation. The collaboration of housewives and the younger generation in developing a typical culinary business has the opportunity to be successful in the future. In order for the business to run smoothly, training is carried out for housewives and the younger generation in the area of the former Kartasura Palace.
PELATIHAN FOTOGRAFI PRODUK MENGGUNAKAN SMARTPHONE UNTUK MENINGKATKAN VISUAL BRANDING PADA UMKM KERAJINAN TANDUK SAPI DESA PUCANG, MAGELANG
Authors: Isnawati Setya Indah , Budiyanto Ari Eko , Ali Ahmad
Published: October 2022

Product photos with smartphones can be a solution for MSMEs in facing the risk of access to the market. Smartphones are now equipped with cameras and photo editing applications that are very adequate and easy to create visual branding. One of the product photos used in the Community Service (PkM) training this time is product photography. The partner of this PkM is "Toko Subur", which is a horn and souvenir handicraft business which is located in Pucang Village, Secang, Magelang. The problem raised is the limitation of soft skills in applying smartphones for product photography purposes. For this reason, the PkM Team provides a solution in the form of simple product photography training using a smartphone and other supporting properties. The method used is direct training using a smartphone or simple property for SMEs "Toko Subur" as well as joint discussions regarding the obstacles they face. The output of this PkM is the formation of soft skills for MSME actors in the field of product photography to create visual branding so that they are able to attract potential consumers and increase sales from both social media and e-commerce.