bluuebunny/crossref_metadata_2025 huggingface dataset:
Randomized Phase IIA Trial of Gemcitabine Compared With Bleomycin Plus Vincristine for Treatment of Kaposi’s Sarcoma in Patients on Combination Antiretroviral Therapy in Western Kenya
Authors: Busakhala Naftali W. , Waako Paul J. , Strother Matthew Robert , Keter Alfred Kipyegon , Kigen Gabriel Kimutai , Asirwa Fredrick Chite , Loehrer Patrick J.
Published: January 2018

Purpose

Kaposi’s sarcoma (KS) is a spindle cell tumor resulting from growth dysregulation in the setting of infection with human herpes virus-8 (also called KS herpes virus). Advanced KS is characterized by poor responses to antiretroviral therapy and some of the chemotherapy readily accessible to patients in low-resource areas. Gemcitabine induced partial and complete regression of AIDS-associated KS (AIDS-KS) in 11 of 24 patients in a pilot study. The current study compares the antimetabolite gemcitabine with the standard care bleomycin and vincristine (BV) in the treatment of chemotherapy-naïve patients with AIDS-KS in a resource-limited setting.

Patients and Methods

Patients with persistent or progressive KS despite treatment with combined antiretroviral therapy were randomly assigned to receive gemcitabine 1,000 mg/m2 or bleomycin 15 IU/ m2 and vincristine 1.4 mg/m2 given twice weekly. The main end point was objective response by bidirectional measurement, adverse events, and quality of life after three cycles of chemotherapy.

Results

Of 70 participants enrolled, 36 received gemcitabine and 34 received BV. Complete response was achieved in 12 patients (33.3%) in the gemcitabine arm and six (17.6%) in the BV arm ( P = .175). The partial response rate was 52.8% (n = 19) in the gemcitabine arm and 58.8% (n = 20) in the BV arm. Both study arms reported similar neurologic and hematologic adverse events; there was statistically significant baseline to post-treatment improvement in health-related quality-of-life scores.

Conclusion

The results of this randomized, phase IIA trial demonstrate gemcitabine activity in chemotherapy-naïve patients with AIDS-KS, on the basis of response rates, adverse events, and health-related quality-of-life scores.
JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders
Authors: Vainchenker William , Leroy Emilie , Gilles Laure , Marty Caroline , Plo Isabelle , Constantinescu Stefan N.
Published: January 2018

JAK inhibitors have been developed following the discovery of theJAK2V617F in 2005 as the driver mutation of the majority of non-BCR-ABL1myeloproliferative neoplasms (MPNs). Subsequently, the search for JAK2 inhibitors continued with the discovery that the other driver mutations (CALRandMPL) also exhibited persistent JAK2 activation. Several type I ATP-competitive JAK inhibitors with different specificities were assessed in clinical trials and exhibited minimal hematologic toxicity. Interestingly, these JAK inhibitors display potent anti-inflammatory activity. Thus, JAK inhibitors targeting preferentially JAK1 and JAK3 have been developed to treat inflammation, autoimmune diseases, and graft-versus-host disease. Ten years after the beginning of clinical trials, only two drugs have been approved by the US Food and Drug Administration: one JAK2/JAK1 inhibitor (ruxolitinib) in intermediate-2 and high-risk myelofibrosis and hydroxyurea-resistant or -intolerant polycythemia vera and one JAK1/JAK3 inhibitor (tofacitinib) in methotrexate-resistant rheumatoid arthritis. The non-approved compounds exhibited many off-target effects leading to neurological and gastrointestinal toxicities, as seen in clinical trials for MPNs. Ruxolitinib is a well-tolerated drug with mostly anti-inflammatory properties. Despite a weak effect on the cause of the disease itself in MPNs, it improves the clinical state of patients and increases survival in myelofibrosis. This limited effect is related to the fact that ruxolitinib, like the other type I JAK2 inhibitors, inhibits equally mutated and wild-type JAK2 (JAK2WT) and also the JAK2 oncogenic activation. Thus, other approaches need to be developed and could be based on either (1) the development of new inhibitors specifically targetingJAK2V617F or (2) the combination of the actual JAK2 inhibitors with other therapies, in particular with molecules targeting pathways downstream of JAK2 activation or the stability of JAK2 molecule. In contrast, the strong anti-inflammatory effects of the JAK inhibitors appear as a very promising therapeutic approach for many inflammatory and auto-immune diseases.
A TALE of shrimps: Genome-wide survey of homeobox genes in 120 species from diverse crustacean taxa
Authors: Chang Wai Hoong , Lai Alvina G.
Published: January 2018

The homeodomain-containing proteins are an important group of transcription factors found in most eukaryotes including animals, plants and fungi. Homeobox genes are responsible for a wide range of critical developmental and physiological processes, ranging from embryonic development, innate immune homeostasis to whole-body regeneration. With continued fascination on this key class of proteins by developmental and evolutionary biologists, multiple efforts have thus far focused on the identification and characterization of homeobox orthologs from key model organisms in attempts to infer their evolutionary origin and how this underpins the evolution of complex body plans. Despite their importance, the genetic complement of homeobox genes has yet been described in one of the most valuable groups of animals representing economically important food crops. With crustacean aquaculture being a growing industry worldwide, it is clear that systematic and cross-species identification of crustacean homeobox orthologs is necessary in order to harness this genetic circuitry for the improvement of aquaculture sustainability. Using publicly available transcriptome data sets, we identified a total of 4183 putative homeobox genes from 120 crustacean species that include food crop species, such as lobsters, shrimps, crayfish and crabs. Additionally, we identified 717 homeobox orthologs from 6 other non-crustacean arthropods, which include the scorpion, deer tick, mosquitoes and centipede. This high confidence set of homeobox genes will now serve as a key resource to the broader community for future functional and comparative genomics studies.
Composite strength technological increase in SHF electromagnetic field
Authors: Злобина Ирина , Zlobina Irina , Бекренев Николай , Bekrenev Nikolay , Павлов Сергей , Pavlov Sergey
Published: January 2018

As a method for the mechanical strength increase in products made of composite and its uniformity increase in a product there is offered a structure modification in a SHF electromagnetic field of a standard frequency range. It is defined that a SHF modification contributes to the increase of bend stress by 11 – 16 %, cut stress increase by 13 – 21 %. During tests for an inter-laminar shear the samples processed withstand stress by 14 – 15 % more than reference samples. The study of the micro-structure in reference samples and processed ones with the use of the fractal analysis procedure has shown that a fractal dimensionality of micro-objects of the structure of material worked increased as compared with a reference sample by 14 – 22 %. This fact may be accepted as one of the mechanisms for material strength increase at the expense of the increase of contact interaction points of the matrix and reinforcing fibers.
Monitoring of the Achievement of Planned Educational Results in the Context of the Technological Training of Schoolchildren
Authors: Лапина Светлана , Lapina Svetlana
Published: January 2018

This article provides a monitoring material to identify the elements of the planned educational results as part of the technical training of schoolchildren using manual artistic work. The description, the short methodology, the results of the test and the recommendations for the application of the developed set of continuing technology education are described.
Ensuring Continuity in the Independent Work of Students
Authors: Кожалиева Д. , Kozhalieva D.
Published: January 2018

The article analyzes the importance, relevance of self-education, self-development in connection with the fact that the approved by the Ministry of Education and Science of the Kyrgyz RepublicState standard of school education of the second generation applies new requirements to students and teachers. In recent years, more attention is paid to the independent work of students in the learning process, in particular in the teaching of mathematics.
A histological analysis of artificial skin in an extensively burned child, 14 years after application: a case report
Authors: Zajicek Robert , Sticova Eva , Königova Radana
Published: January 2018

Introduction:

Artificial skin has become the treatment of choice in extensive, full-thickness thermal injuries. The longest follow-up of the healing process in burn sites covered with the Integra Bilayer Matrix Wound Dressing onto the wound published to date was at around five years after application. In our case report, we describe the clinical and histological analysis of an extensive, full-thickness thermal injury 14 years on from treatment with the bilayer matrix wound dressing.

Case study:

A nine-year-old boy suffered a full-thickness skin loss over 85% of his body surface area following a fire accident. The bilayer matrix wound dressing was used on both legs and covered almost 30% of his body surface area. Cosmetic and functional results were satisfactory. Histological analysis performed nine years after the application of the bilayer matrix wound dressing onto the wound showed a double-layered skin composition with changes in the fibrous component of the dermis.

Conclusion:

Despite satisfactory short- and long-term clinical results from applications of the bilayer matrix wound dressing, we found important differences in microstructure when compared with the physiological condition.
Neighbourhood: A Threatened Heritage in Contemporary Europe
Authors: Grande Nuno , Cremascoli Roberto
Published: January 2018

Europe is currently experiencing an identity crisis. The defence mechanisms of the material heritage are presently insufficient to safeguard the significant European intangible heritage: people and their citizen relations gradually conquered throughout history, based on values ​​of proximity, tolerance and multiculturalism; in brief, on the basis of the "neighbourhood" exercise, a concept intrinsically linked to the idea of ​​Europe. What social heritage should be safeguarded against such phenomena as “ghettoization”, “gentrification” and “touristification” in European cities? This article focus on four neighbourhoods designed by Álvaro Siza, in Venice, The Hague, Berlin and Porto, but above all on their exhibition at the XV Venice Architecture Biennale, in 2016, and concomitant analysis, seeking to rediscover these places where a Europe of many identities still resides and is made up of multiple neighbours.
Ni antiguos ni modernos. Educación y política en tiempos de José I en España (1808-1813)
Authors: Perrupato Sebastián
Published: January 2018

En el presente trabajo se pretende analizar las propuestas y reformas educativas que se realizaron durante el interregno de José I en España. Se entiende que la crisis de la Monarquía hispánica llevó a los intelectuales a un planteamiento que tendía a pensar la educación y la política como partes constitutivas del complejo campo revolucionario sobre el cual se debía elaborar el sistema educativo estatal. En este sentido, la política educativa del «monarca intruso» tendió a modernizar la educación a fin de convertirla en un dispositivo de control social. Sin embargo, las tendencias tradicionales españolas, muy presentes aún en el siglo XIX, convirtieron esta empresa en una tarea difícil en la que las propuestas educativas pivotaban entre antiguos y modernos sin lograr consolidar un sistema educativo estatal.
Unamuno: las funciones educativas del estado. Del estado docente al estado organizador de la enseñanza
Authors: Maroco Dos Santos Enmanuel José
Published: January 2018

El artículo pretende determinar los fundamentos políticos de la educación propuesta por Unamuno, que, en muchos sentidos, comulga con la posición defendida por los regeneracionistas, en su época histórica, siendo cierto que su postura aporta algunas matizaciones connotativas a raíz de su peculiar concepción de la enseñanza laica, ya que, como es bien sabido, en Unamuno el concepto laico no pierde sentido religioso, al vincularse con la religión católica popular española (Volksgeist).La democratización de la enseñanza, el estatismo docente y la antipolitización de la enseñanza son los tres principios políticos más característicos de nuestro autor, pese al hecho de que éste se haya desvinculado de su defensa de la «escuela única» después de la aprobación de la Constitución española de 1931, en virtud de su reacción a los artículos 26 y 48.El presente trabajo, sin olvidar el ambiente cultural de la época, se centra, fundamentalmente, en el pensamiento de Unamuno, procurando determinar la coherencia interna de sus postulados y principios educativos.
Alberto Bonet y su estudio sobre la conciencia moral del niño (1927): a propósito de los primeros trabajos sobre la educación moral en la Universidad de Barcelona
Authors: Payá Sánchez Monserrat , Vilanou Torrano Conrad
Published: January 2018

En este trabajo los autores presentan un análisis histórico de la tradición filosófica catalana (Ramón Martí de Eixalá, Francisco J. Llorens Barba, Tomás Carreras Artau, etc.) que se caracteriza por una filosofía de la conciencia, de innegables consecuencias educativas. Si en Madrid triunfó el krausismo, en Cataluña se aclimató la escuela del sentido común que destaca la conciencia tanto en el orden del conocimiento como en la praxis moral. La llegada de Tomás Carreras Artau a la cátedra de Ética de la Universidad de Barcelona en 1912 propició la aparición de un Seminario, entre cuyos trabajos descuella el libro de Alberto Bonet –futuro dirigente de la Acción Católica Española– sobre la conciencia moral del niño (1927). A pesar de que este Seminario de Ética quedó un tanto arrinconado por el Seminario de Pedagogía que abrió Joaquín Xirau en 1930, lo cierto es que el magisterio de Alejandro Sanvisens –el discípulo predilecto de Tomás Carreras Artau– permitió la configuración de una pedagogía de la conciencia que se encuentra en la base de los estudios sobre educación moral generados en la Universidad de Barcelona, al abrigo del GREM (Grup de Recerca en Educació Moral), fundado en 1988.
Explorando intersecciones entre religión y prácticas y teorías educativas en escenarios Canadienses y Europeos
Authors: Bruno-Jofré Rosa , Quiroga Uceda Patricia
Published: January 2018

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Entre José Castillejo y José M.ª Albareda: Julio Palacios, el «último presidente» de la Junta para Ampliación de Estudios, 1939-1940
Authors: Fernández Terán Rosario E. , González Redondo Francisco A.
Published: January 2018

Cuando el final de la Guerra Civil se avizoraba inmediato, las nuevas autoridades franquistas encomendaban a Julio Palacios, catedrático de la Universidad Central de Madrid, lo que José M.ª Albareda denominaría, en mayo de 1939, la «misión rectora de nuestra vida científica». En síntesis, la «suprema dirección», con una dedicación análoga a la de José Castillejo antes de la guerra, de los centros que hasta entonces habían pertenecido a la Junta para Ampliación de Estudios (JAE) y a la Fundación Nacional para Investigaciones Científicas (FNICER). Esta tarea de reconstrucción de las instituciones educativas tras la contienda, que llevaría a cabo desde la Vicepresidencia del Instituto de España y hasta que Franco inaugurase el CSIC el 28 de octubre de 1940, invita a considerar a Julio Palacios como el «último presidente» de la JAE.
Francisco de Frutos. Maestro de primeras letras purificado. Segovia 1823
Authors: Manrique Sanz José Luis
Published: January 2018

La importancia de la ciudad de Segovia como centro de producción de paños en el siglo XVI dejó paso en siglos posteriores a una lenta y profunda decadencia. Sin embargo, a mediados del siglo XVIII, el fabricante de paños e ilustrado. D. Diego Ochoa de Hondategui dejó toda su fortuna, casi 4 millones de reales, destinada a obras pías y educativas. Un colegio para niños pobres y huérfanos y una escuela de primeras letras fue el lugar donde transcurrió la vida docente del maestro Francisco de Frutos Illanas. Obligado durante el trienio constitucional a enseñar el Catecismo Político de la Constitución española de 1812, a la vuelta de Fernando VII en 1823, primero fue tenido por «negro» y después purificado.
MORPHOLOGICAL AND ECOLOGICAL OBSERVATIONS ON CHIROMANTIS VITTIGER (ANURA: RHACOPHORIDAE) IN MOUNT HALIMUN - SALAK NATIONAL PARK, INDONESIA
Authors: Kusrini Mirza Dikari , Lubis Muhammad Irfansyah , Darmawan Boby , Rahman Luthfia Nuraini
Published: January 2018

Despite an early description, the rhacophorid frog (Chiromantis vittiger (Boulenger 1897)) is relatively poorly known species. It has been found in several areas in the mountainous part of western Java, one of which is in the Chevron Geothermal Indonesia (CGI) concession area within Mount Halimun-Salak National Park. An ecological study of this species and its habitat was conducted in CGI from April to September 2008. The biological and ecological aspects of this tree frog such as morphology, habitat characteristics, breeding behaviour, and larval development are presented in this paper. This study found that the fertilised eggs hatch as free-swimming tadpoles. In addition, the availability of artificial habitat in the form of concrete ponds helps sustain the population throughout the year. We also report parental care in this species.
PHYLOGENETIC RELATIONSHIPS OF LEPTOBRACHIUM HASSELTII TSCHUDI, 1838 (AMPHIBIA, ANURA, MEGOPHRYIDAE) - DETECTION OF A POSSIBLE CRYPTIC SPECIES
Authors: Hamidy Amir , Matsui Masafumi
Published: January 2018

By examining mitochondrial DNA phylogeny using 2424bp of sequence data 12S rRNA, tRNAval, and 16S rRNA genes, we evaluated the taxonomic relationships among Javan litter frogs Leptobrachium hasseltii from southern Sumatra, Java, and Bali. Leptobrachium hasseltii formed a well-supported monophyletic group, which comprised two major clades. One major clade represented the southern Sumatran and Javan populations and the other consisted of the population from Bali. The Javan and southern Sumatran clade included two subclades: the West Javan-southern Sumatran group and the Central Javan group. The genetic divergence between the two major clades (Bali vs. Java-Sumatra) suggested their separation happen at species level. Further studies using morphological and acoustic data are needed to determine the taxonomic status of Bali population.
The Financing Problems Facing the Agricultural Sector in Nigeria and the Prospect of Waqf-Muzaraah-Supply Chain Model (WMSCM)
Authors: Olaniyi Oladokun Nafiu , Thaker Mohamad Asmy Bin Mohd Thas , Thaker Hassanudin Mohd Thas , Pitchay Anwar Allah
Published: January 2018

Agriculture sector becomes important sector in many developing countries including in Nigeria. The contribution of agricultural sector to the development of Nigeria is considerable. This important sector was the economic backbone upon which the government of the Federal Republic of Nigeria relied for its foreign exchange and revenue. A country was once a net exporter of agricultural products. However, since the discovery of oil in the early 1960, agricultural productivity has continually decreased due to many problems, especially related to financial aspect. Several programmes and policies have been adopted by various administrations to find solution to the dwindling agricultural productivity but to no avail. These solutions have mainly focused on alleviating the financial problems the farmers face. Usually financial intermediaries including banks would provide micro-financing to the farmers but with high interest rates coupled with collateral requirements. Hence, this mode of financing has not produced any significant result. This study will therefore examine problems facing agricultural sector in Nigeria with special emphasis on its financial aspect and propose a Waqf-MuzaraahSupply Chain model (WMSCM). Under this model, Waqf fund will be used for providing financial facility of the farmers. The relationship between farmers and financial institutions is based on partnership where profit and loss will be shared by both parties. This will enhance commitment by and cooperation among both parties to ensure the success of the business. Furthermore, the issues of collateral and high interest rate that constrain the financial ability of the farmers and their agricultural output are inherently solved by the model. Moreover, the model has features of investment and risk diversification for both the financial institutions and the farmers that will lead to high agricultural productivity and employment generation in the economy.
Penerapan Composite Logic dalam Mengkolaborasikan Framework Terkait Multimedia Forensik
Authors: Lizarti Nora , Sugiantoro Bambang , Prayudi Yudi
Published: January 2018

Like the digital forensics in general, multimedia forensics requires an integrated and flexible framework that can guide the process of proof is procedurally in order to maintain the validity of a digital evidence so that it can be justified in court. But this time, the digital forensics investigation framework that develops more emphasis on computer forensic investigations in general and did not give a specific stage of multimedia forensics. Often in investigating multimedia forensics investigator uses a framework that vary depending on the type of multimedia content to be analyzed, of course it becomes inflexible and inefficient, whereas multimedia content share characteristics that allow it to be integrated into a single unit. This study develops a forensic multimedia framework by implementing the Composite Logic to collaborate on several multimedia framework and related documents. Logic Composite method is a method of modeling the distribution of structured logical modularization techniques with explicit interface in which a model consists of a set of components that are interconnected with the principle of decomposition. In other words, the application of this method will allow researchers to extract and merge several frameworks into a single unit does not eliminate the function and the basic structure of the frameworks.
EKSISTENSI PESANTREN DAN KONTRIBUSINYA DALAM PENDIDIKAN KARAKTER
Authors: Hamruni Hamruni , W. Ricky Satria
Published: January 2018

Historically, boarding schools (pesantren) since its inception has never silent in face of religious social problems. Activities pesantren in response to global problems has been demonstrated since the early days of glory. Involvement of schools in globalized world has been proved by historical facts are not possible to be denied. Pesantren with various elements of education has been able to develop character education to be maximal. This is reflected in planting of theoretical value obtained from studies book in form of real practices in daily life. Habit can form a good character to students, and process naturally without forced. Success of schools in shaping character invites many other institutions to emulate design of schools, ie educational boarding. Many education experts believe that concept of a boarding education such as that implemented by schools actually capable of shaping students’ character.
PENGEMBANGAN KURIKULUM PENDIDIKAN AGAMA ISLAM PADA PENDIDIKAN TINGGI
Authors: Suwadi Suwadi
Published: January 2018

This study aims at finding the development of Islamic education curriculum in higher education. Curriculum development conceived as an effort to develop a curriculum that refers to the Indonesian Qualifications Framework (KKNI), National Standards for Higher Education (SNPT), and Paradigm Integration-Interconnection Studies as the orientation of scientific development at UIN Sunan Kalijaga. This study was conducted by means of naturalistic qualitative approach. The location of this study was at the Department of Islamic Religious Educatioan of Faculty of Islamic Education and Teaching UIN Sunan Kalijaga Yogyakarta. The subjects consisted of cases which are selected by purposive sampling techniques. The study procedure of collecting data consisted of four steps: observation, in-depth interviews, and document study. The data were analyzed using inductive models, while the validity of the result met the criteria of credibility, transferability, dependability and conformability. The research findings are as follows: first, the emphasis on curriculum development (a) clarity profile of graduates with a description of its operation. (b) The learning outcomes as an indicator graduate profile that refers to KKNI and SNPT. (c) Field studies as a strategic issue which combined with the development of the course learning outcomes, (d) Half the weight of the unit credits obtained by multiplying the depth and breadth of study material; Second, the development of the curriculum to accommodate all the requirements of a professional teacher with four competencies; pedagogical, personality, social and professional competence, plus the competence of the leadership. Third, curriculum development in PAIDepartment also stressed on the aspect of PAI consisting of Al-Qur’an Hadith, Aqidah Akhlak, Fiqh, Sejarah Kebudayaan Islam to improve the professional competence of future teachers.
DISKURSUS PEMBANGUNAN MANUSIADALAM PERDA SYARÎ’AH
Authors: Muhlasul Ahmad
Published: January 2018

Since its emergence, sharia nuanced regulations reap controversy. They are lately suspected as a part from project of International khilafah or even regarded as a part from project of radicalization laden with the smell of sectarian. There’s not little academic who regards that the existence of perda sharia as something that is contra productive and defies with the concept of nationalism intimated with Bhinneka Tunggal Ika (Unity in Diversity), also with the vision of global development, is the vision of human development followed by the whole countries in the world as a benchmark for development. This article is a summary from the whole research about the dimension of human development within perda sharia containing about the contestation between the vision of domestic and global policy. It is a literacy/library research using qualitative approach served and analyzed descriptively employing the theory of (development) Capabilitiy by Amartya Sen and Theory of Public Policy. The research is aimed to give a description about the relevance of Perda Sharia towards the concept of global development. The result of the research shows that there is conflict and tension between the vision of domestic and global policy. This thing is showed by the dominance of the incoherence between the content and context of perda sharia with the concept of human development and the latest models of policy developed by the UN.Sejak kelahirannya, Perda-Perda bernuansa Syarî’ah menuai kontroversi. Belakangan ia ditengarai sebagai bagian dari proyek khilafah internasional atau bahkan dianggap bagian dari proyek radikalisasi yang sarat dengan aroma sektarian. Tidak sedikit kalangan akademis yang menganggap bahwa keberadaan Perda Syarî’ah sebagai hal yang kontraproduktif dan bertentangan dengan konsep nasionalisme yang berbhinneka tunggal ika, serta bertentangan dengan visi pembangunan global, yaitu visi Pembangunan Manusia yang dianut oleh semua negara di dunia sebagai tolak ukur pembangunan.Artikel ini merupakan ringkasan dari keseluruhan penelitian tentang Dimensi Pembangunan Manusia dalam Perda Syarî’ah yang memuat tentang kontestasi antara visi kebijakan domestik dan global. Penelitian tersebut merupakan penelitian pustaka (literasi/library research) dengan pendekatan kualitatif yang disajikan dan dianalisa secara deskriptif menggunakan teori (Pembangunan) Kapabilitas Amartya Sen dan Teori Kebijakan Publik. Penelitian ditujukan untuk, memberikan deskripsi tentang relevansi Perda Syarî’ah terhadap Konsep Pembangunan global.Hasil penelitian menunjukkan adanya konflik dan ketegagan antara visi kebijakan domestik dan global. Hal itu ditunjukkan oleh dominannya inkoherensi antara kontent dan konteks Perda Syarî’ah dengan Konsep Pembangunan Manusia dan Model-Model Kebijakan terkini yang dikembangkan oleh PBB (UNDP).Key Words: Human Development, Sharia Law and Nationalism
NEGOSIASI OTORITAS KEPEMIMPINAN PONDOK PESANTREN PABELAN MASA KEPEMIMPINAN KYAI HAMAM DJA’FAR 1965-1993
Authors: Ghafur Muhammad Ikhsan
Published: January 2018

Pesantren is an institution where its leadership is based on the descendants of the founders. However, with the development of the era, pondok pesantren has begun to experience system changes such as bureaucracy in it. This pesantren bureaucratization have an impact on the authority of kyai in which the leadership based on descendants turns into a certain qualification. The existence of pesantren bureaucratization does not eliminate the traditional authority. This is because in this bureaucracy there are some family members who have a certain position, so that between the traditional and legal authority are still applied in the modern pesantren. The combination of traditional authority and legal authority has become a demand for the survival of pesantren. The existence of traditional authority is due to the culture that exists in society, while legal authority has become a necessity of the development of the era.Pesantren merupakan lembaga di mana kepemimpinannya berdasarkan keturunan dari pendiri. Namun dengan adanya perkembangan zaman, pondok pesantren sudah mulai mengalami perubahan sistem di dalamnya dengan adanya birokrasi di pesantren. Birokratisasi pesantren ini tentunya berdampak pada otoritas kyai di mana kepemimpinan berdasarakan keturunan berubah menjadi kualifikasi tertentu. Adanya birokratisasi pesantren tidak menghilangkan otoritas tradisional yang ada. Hal ini dikarenakan di dalam birokrasi tersebut terdapat beberapa anggota keluarga yang menjabati posisi tertentu, sehingga antara otoritas tradisional dan legal tetap berlaku di dalam pondok pesantren modern. Gabungan antara otoritas tradisional dan otoritas legal sudah menjadi tuntutan untuk keberlangsungan hidup pesantren. Adanya otoritas tradisional disebabkan budaya yang ada di masyarakat, sementara otoritas legal sudah menjadi kebutuhan dari perkembangan zaman.Keywords: pesantren, heredity, bureaucracy and authority
MEMBINA KELUARGA BAHAGIA SEBAGAI UPAYA PENURUNAN KEKERASAN DALAM RUMAH TANGGA (KDRT) DALAM PERSPEKTIF AGAMA ISLAM DAN UNDANG-UNDANG
Authors: Nurmadiansyah M. Thoriq
Published: January 2018

This article talks about efforts to foster happy families to anticipate domestic violence. The perspective discussed would be in the in the views of Islam and the law in Indonesia. The existence of domestic violence is a fact in the social life of Indonesian families, many women and children have fallen victim thereto. Domestic violence could be avoided and reduced is the commitment constructed between husband and wife is consistent with the teachings of Islam and the relevant legal provisions. A proper understanding of respective roles, rights and obligations  would lead to happy families and the extinction of domestic violence.
BOOK REVIEW: Perempuan Indonesia dalam Memahami Hak dan Kewajibannya dalam Keluarga
Authors: Marhumah Ema
Published: January 2018

Judul : Berbeda tetapi Setara, Pemikiran tentang KajianPerempuan Penulis  : Saparinah SadliPenerbit : Jakarta, KompasTahun : 2010Penyunting : Imelda Bahtiar Jumlah Halaman  : 532 halaman ISBN : 9797094812Ukuran : 150 x 230mmProf Dr Saparinah Sadli (84) dilahirkan di Tegalsari, Jawa Tengah pada tanggal 24 Agustus 1927. Suami beliau bernama Prof Dr Ir Mohammad Sadli, MSc (suami, almarhum). Beliau mengenyam pendidikan di Fakultas Farmasi Universitas Gadjah Mada (UGM), (Sarjana Muda 1953). Kemudian beliau melanjutkan studinya  ke Program Pascasarjana Fakultas Psikologi Universitas Indonesia (1961) dan Doktor Psikologi UI (1976). Adapun kegiatan penting yang pernah digelutinya adalah sebagai ketua Komisi Nasional Anti Kekerasan terhadap Perempuan (Komnas Perempuan, 1998-2004), mendirikan Pusat Studi Kajian Wanita UI, Anggota Komisi Nasional Hak Asasi Manusia (1996-2000), Tim Gabungan Pencari  Fakta (TGPF) kasus kerusuhan 13-15 Mei 1998, di mana kekerasan seksual menjadi bagian integral (23 Juli-23 Oktober 1998) dan Menulis banyak tulisan ilmiah dan artikel. Bukunya antara lain, Menjadi Perempuan Sehat dan Produktif di Usia Lanjut (2007). Beliau juga aktif di dunia olah raga dalam rangka penyiapan atlet putri di bidang bulu tangkis.
NALAR IJTIHAD JILBAB DALAM PANDANGAN M. QURAISH SHIHAB (Kajian Metodologi)
Authors: Wartini Atik
Published: January 2018

Discussion of the jilbab is truly very interesting. In several past studies, the concept of wearing the jilbab has  been seen as very controversial. There have been several contemporary Islamic scholars (ulama) with interesting perspectives on the jilbab. One of these Indonesian scholars is the Islamic interpretor (Mufassir) M. Quraish Shihab, who has written a book on the jilbab. Although the jilbab is not the area of concern of the author, using prior knowledge I will look at M. Quraish’s rationale in making the controversial decision to write on the jilbab and also at his research methodology. It is his research methodology on law-making that the author particularly focuses on in this paper.
FEMINISME DARI PERSPEKTIF PROTESTAN
Authors: Taranau Vic. Dianita Aprissa L.
Published: January 2018

Artikel ini mencoba menggambarkan teologi feminis menurut perspektif Kristen Protestan yang melihat bahwa  masalah ketidakadilan dan kekerasan adalah masalah teologi yang dikategorikan sebagai pelanggaran iman. Sehingga perlu adanya upaya untuk mereinterpretasi Alkitab dan membacanya dengan mata baru agar dapat menemukan wajah Yesus yang dalam pelayananNya. Berdasarkan penelitian didapatkan Kalangan Protestan memahami segala bentuk kekerasan fisik maupun nonfisik, makro maupun mikro, bukan lagi sekedar bentuk pelanggaran HAM tetapi juga sebagai pelanggaran iman. Namun, Gereja pun dapat menjadi lembaga yang paling diskriminatif terhadap perempuan.
KRITIK NALAR HADIS MISOGINIS
Authors: Muqtada Muhammad Rikza
Published: January 2018

Tulisan ini memberikan kritik terhadap nalar yang sering menggunakan hadis-hadis shaḥīh sebagai dalil  doktriner untuk sebuah kepentingan. Di antara yang sering dirujuk adalah hadis shahih yang ada dalam Saḥīh al-Bukhāri. Dalam urusan relasi antara laki-laki dan perempuan, misalnya. Kaum maskulin sering menggunakan hadis Saḥīh al-Bukhāri untuk melegitimasi segala tindakan laki-laki dalam memperlakukan perempuan, juga untuk memperkokoh posisi superioritas laki-laki atas perempuan. Dengan menggunakan  hermeneutika kritis, saya mengajak pembaca untuk cerdas membaca hadis-hadis misoginis yang sudah diklaim shaḥīḥ, karena dibalik kesahihannya ternyata ada hal yang “didiamkan”, meliputi sisi sosio-historis, sisi relasi kekuasaan, sisi intertekstualitas, juga sisi struktural-linguistik. Sehingga hadis yang menyatakan perempuan memiliki kekurangan agama dan akal, di mana dalam tradisi Jawa diistilahkan sebagai “konco wingking”, terbantahkan oleh fakta keterlibatan perempuan dalam banyak sektor publik. Keterlibatannya itu justru bukti bahwa mereka memiliki kemampuan akal yang mumpuni.
A Comparison of Antimetastatic Activity between Nerium indicum and Cinnamomum burmannii on 4T1 Cells
Authors: Lestari Beni , Muntafiah Laeli , Walidah Ziana , Jenie Riris Istighfari
Published: January 2018

Metastatic process becomes a major problem in advanced cancer cases. Natural compounds found in several plants in Indonesia have a potency to be developed as chemoterapeutic agent which are targeted to metastatic process. Jure leaves (Nerium indicum) which contain oleandrin and cinnamaldehyde in cinnamon bark (Cinnamomum burmannii) reported to have cytotoxic activity on several cancer cells, but their activities on metastasic process have never been explored. This research aims to reveal and to compare their anti-metastatic effect toward 4T1 breast cancer cells. The cytotoxicity of jure leaves extract (JLE) and cinnamon essential oil (CEO) was obtained by MTT assay. Metastatic process mainly on cell migration was examined by scratch wound healing assay while MMP-9 expression that described the invassion process was observed by gelatin zymography assay. Molecular interaction between their active compounds and MMP-9 receptor was predicted by molecular docking. The result showed that treatment with JLE and CEO inhibited the growth of 4T1 cells with IC50 value of 125 µg/mL and 2.5 µg/mL, respectively. In addition, JLE performed inhibitory effect of cell migration better than CEO. Meanwhile, both JLE and CEO decreased MMP-9 protein expression. Thus, JLE and CEO have potentials to be developed as an anti-metastatic agent and JLE could be more effective.Key words: Nerium indicum, Cinnamomum burmannii, anti-metastasis, scratch assay, gelatin zimography
Creating demand for the tourist product during the implementation of geotourist project for post-mining objects
Authors: Kobylańska Malwina
Published: January 2018

The experience of recent years shows that geotourism in post-mining objects has got a large development potential due to, among others, moving away from the typical museums to modern tourism products much more engaging visitors and the transition from the idea of 3S (sun, sand, sea) for 3E (experiment, excitement, education) and 4H (heritage, handicraft, habitat, history). In the article the specifics of the tourism product in projects related to the adaptation and using of post-mining objects and sites were presented. The article presents an assessment of the possibility of building a branded tourist product based on the relics of the mining industry in the context of the development and implementation of subsequent phases of the project consisting in making these relics available to tourists. The examples of completed projects, among others, in Poland and Germany were used. The division of the primary and secondary value of the geotourist project and the activities affecting the increase of these values were proposed. The article also raises issues of variation in demand for mining heritage products and the economic viability of such projects, as well as the recommendations for future investor in the post-mining tourism’ venture were specified.
On the Monte Carlo Matrix Computations on Intel MIC Architecture
Authors: Karaivanova Aneta , Alexandrov Vassil , Gurov Todor , Ivanovska Sofiya
Published: January 2018

The tightened energy requirements when designing state-of-the-art high performance computing systems lead to the increased use of computational accelerators. Intel introduced the Many Integrated Core (MIC) architecture for their line of accelerators and successfully competes with NVIDIA on basis of price/performance and ease of development. Although some codes may be ported successfully to Intel MIC architecture without significant modifications, in order to achieve optimal performance one has to make the best use of the vector processing capabilities of the architecture. In this work we present our implementation of Quasi-Monte Carlo methods for matrix computations specifically optimised for the Intel Xeon Phi accelerators. To achieve optimal parallel efficiency we make use of both MPI and OpenMP.
Quality of Milk for Cheese Production on Registered Agricultural Holdings in Vojvodina
Authors: Popović Vranješ Anka , Krstović Saša , Kasalica Anka , Jurakić Želјka , Štrbac Ljuba , Strugar Katarina , Šaran Momčilo
Published: January 2018

Currently, milk producers in Vojvodina on registered agricultural holdings (RAHs) have great experience and knowledge in managing their farms, including primary production, processing and sales. However, for a smaller number of manufacturers, there is still room for organizational and technological improvement of production. Nowadays, goat breeding is a very important part of sustainable production, rural development, and represents a very important part of rural development and employment of people. The course of goat breeding in our country is milk-meat, where milk is usually a priority. For the successful production of cheese, the quality of raw milk plays a critical role. It affects the quality of cheese in terms of a chemical composition, microbiological quality, the presence of chemical residues and organoleptic properties. Cheese is mostly made from cow, goat and sheep milk. The valuable components of milk are proteins and fats. These can also be defined as parameters of utilization, since they indicate how much cheese can be obtained from milk. On average, cow milk contains 3.64% fat, 3.22% protein, and 8.52% non-fat dry matter (NFDM). Higher differences in milk fat content (minimum 3.25%, maximum 4.36%) were found in milk from RAHs. Recently, the production of milk with higher fat content has become important, since in Serbian milk there is not enough milk fat, so some processors are obliged to import it in the form of butter and cream. In addition to the chemical composition, the microbiological quality of milk is important to maintain successful cheese production. Regarding our findings, the standard plate count (SPC) and the somatic cell count (SCC) in samples from most RAHs did not exceed the values specified in Regulation (EC) 853/2004. Moreover, goat and sheep milk was in agreement with the technological quality of milk for cheese production, in terms of chemical composition.
Sudangrass (Sorghum Sudanense Pers.) in the Reclamation of Technosols in the Stanari Mining Area
Authors: Malić Nenad , Matko Stamenković Una , Marković Mihajlo , Kovačević Zlatan
Published: January 2018

The surface exploitation of mineral raw materials inevitably changes the environment, thus resulting in soil degradation. This paper presents the results of growing sudangrass (Sorghum sudanense Pers.) in the reclaimed Deposol (technosols) in the Stanari Coal Mine area. Green manuring was the cultural practice used for sudangrass growing and land reclamation. The purpose of this research is to increase the amount of organic matter in the Deposol surface layer. The research was performed within a two-year period (2009-2010) at the experimental (technosol) site of the Stanari Coal Mine, located on the inside part of the overburden deposition site, near the Raskovac pit. The research of green manuring included a two-factor experiment with four replications. Two cultivars of sudangrass (Factor A) were used with three fertilization treatments (Factor B). The soil analyses indicated a sandy and low fertile soil. The experimental plot Deposol showed favorable physical properties, whereas its chemical and biological properties proved very unfavourable. The highest yield of biomass (29.15 t ha-1), as well as the dry matter (10.30 t ha-1), was recorded in the cultivar ‘Piper Sweet’ (in 2009), which was completely treated with mineral fertilizers. The lowest yields of biomass (2.05 t ha-1) and dry matter (0.95 t ha-1) were observed in the cultivar ‘Srem’ in 2010. Statistically significant differences were found between the treatments applied, emphasizing that only certain cultivars of sudangrass and types of fertilization (encompassing reasonably high amounts of nitrogen) can significantly increase the amount of organic matter in Deposol.
Criterial suppliers’ evaluation model aimed at SCM performance, production and engineering process’s improvement
Authors: Dumitrascu Oana
Published: January 2018

This paper focuses on the suppliers’ evaluation and selection and aims to develop a criterial model of suppliers’ evaluation as an innovative method for engineering and business education. This new method comes with the purpose of organisational supply chain management performance growth, by improving the entire supply chain system and engineering process, and bringing contribution to the specialty literature in this field. The research methodology is based on qualitative research. The bibliographic research from various secondary sources is used, such as diverse books, scientific articles, reports and information material. In order to achieve a high performance in an organisation it is necessary to monitor and control the procurement process. Certain gaps have been identified in identifying a supplier rating and selection system based on both logistical, financial, price or quality aspects. As an own contribution, this paper proposes a criterial model of evaluating and selecting suppliers, based on specific aspects related to the product, services, delivery and to the financial situation. The motivation of choosing this model is found in its capacity of noticing the negative aspects regarding the relationship between an organisation and its suppliers and finding out the improvement aspects, with a high impact on the engineering process’ and supply chain management’s improvement. The model offers the possibility to benchmark the suppliers, aspect which favours the potential collaboration with future suppliers.
Experiential learning with living ants
Authors: Antofie Maria Mihaela , Tița Luciana , Sand Sava Camelia
Published: January 2018

Experiential learning implying living animals is a powerful tool for accessing positive emotions such as curiosity as well as for changing attitudes or acquiring new values for the further development of the pupils or students. However, formal curricula in schools is legally binding document for ensuring its contribution to agreed competencies, skills, attitudes and values. Therefore, the classical manuals are more cheap and easy to be implemented in the class. However, curricula are not excluding the development of activities in the class in the same curricula in Romania as in many other countries. The purpose of this article is to evaluate knowledge generation based on experiential learning. As a methodology specific lessons and methods have been implemented in curricular and extracurricular activities implying living ants during the biology class of VI grade under the curricula lesson entitled Insects. Our results proved that implementing activities with living animals is positively correlated with an increased curiosity, selfreflection, responsibility and prejudice phasing out. Moreover, tested pupils passed all evaluation tests even they mist, some of activities compared to control group that was learn by classic methods. Parents tests results proved that these emotions and attitudes are also observed during their home activities.
Teaching methodology for Design for Six Sigma and Quality techniques – an approach that combines theory and practice
Authors: Nicolaescu Sergiu Stefan , Kifor Claudiu Vasile
Published: January 2018

Quality techniques and Design for Six Sigma methodology are complex areas that need to be understood through correlation of theoretical and practical teaching. Universities started to apply different approaches for achieving better results, on building greater knowledge and skills for their students. The paper presents a methodology of teaching quality techniques and DFSS methodology, an approach that is focused on understanding the concepts through technical examples from industry and applying the knowledge within a project. A model is proposed for teaching Design for Six Sigma methodology through a workshop done in the classroom. The students are split into groups and will practically work through the main elements of DFSS methodology, for improving the quality of a chosen product by re-designing it. The objective of research is to analyze the performance of this methodology and to identify the strong points. The measurement is done through feedbacks received from students, that is presented at the end of the paper. The methodologies used during research consist of bibliographic research, observational study on classroom, questionnaire and interview technique.