bluuebunny/crossref_metadata_2025 huggingface dataset:
Concerning intent, interpretation, memory and ambiguity in the work of an informal collective working on the Western Sahara conflict
Authors: Baers Michael
Published: June 2019

In October 2016 I made my first visit to the refugee camps of Western Sahara’s Saharawi people near the Algerian town of Tindouf. This was an opportunity to advance my research on the work of an “informal collective” who work with a collection of photographs belonging to Moroccan soldiers, seized by SPLA (Saharawi People’s Liberation Army) over the course of 15 years spent fighting Moroccan forces. In this essay, I conceptualize the relationship between two disparate practices centering around photography—that of the Saharawi’s political organization, the Front Polisario, and the work undertaken by this informal collective. The latter’s work involves exploring the ontological coordinates of these photographs in a dialogical setting. Besides probing the many resonances between the group’s work and the Polisario’s treatment of the photographs of Moroccans in their possession, this essay is also concerned with the relationship between the conflict and its medial representation.
Milieus of memory: Within, across, and between the Mashreq, the Maghreb, and Europe
Authors: Nikro Norman Saadi
Published: June 2019

The thematic of “place” has since the work of Pierre Nora accrued much conceptual currency in social and cultural memory studies. Nora had defined place as lieu, formal remants of a vanishing notion of memory as social practice. Suggesting an alternative notion of place as milieu, the discussion focuses on social memory as proliferations of present-pasts.
EGFR-AS1/HIF2A regulates the expression of FOXP3 to impact the cancer stemness of smoking-related non-small cell lung cancer
Authors: Qi Haolong , Wang Shanshan , Wu Juekun , Yang Shucai , Gray Steven , Ng Calvin S.H. , Du Jing , Underwood Malcolm J. , Li Ming-Yue , Chen George G
Published: June 2019

Background:

Early data showed that FOXP3 could induce epithelial-mesenchymal transition by stimulating the Wnt/β-catenin signaling pathway in non-small cell lung cancer (NSCLC). However, how the expression of FOXP3 is regulated in NSCLC remains unknown. We thus explored the impacts of the long noncoding RNA EGFR antisense RNA 1 (EGFR-AS1) and hypoxia-inducible factor-2A (HIF2A) on FOXP3 expression and the cancer stemness of NSCLC.

Methods:

Lung tissues samples from 87 patients with NSCLC and two NSCLC cell lines were used in this study. The regulation of FOXP3 and lung cancer cell stemness by EGFR-AS1 and HIF2A was determined at molecular levels in NSCLC tissue samples and cultured cells in the presence/absence of the smoking carcinogen, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (also known as nicotine-derived nitrosamine ketone). The results were confirmed in tumor xenograft models.

Results:

We found that NNK decreased the expression of EGFR-AS1 in the long term, but increased the expression of HIF2A and FOXP3 to stimulate lung cancer cell stemness. EGFR-AS1 significantly inhibited FOXP3 expression and NSCLC cell stemness, whereas HIF2A obviously promoted both. The enhancement of lung cancer stemness by FOXP3 was, at least partially, via stimulating Notch1, as the inhibition of Notch1 could markedly diminish the effect of FOXP3.

Conclusions:

FOXP3, the expression of which is under the fine control of EGFR-AS1, is a critical molecule that promotes NSCLC cancer cell stemness through stimulating the Notch1 pathway.
New Design of a Percutaneous Port System for Continuous Intraperitoneal Insulin Infusion
Authors: Rieger Cosima , Kurz Klaus , Mueller-Hoffmann Wiebke , Gehr Bernhard , Liebl Andreas
Published: June 2019

Insulin-dependent diabetes mellitus is treated with intensive insulin therapy using multiple daily injections or continuous subcutaneous insulin infusion with insulin pumps. For people with diabetes who cannot achieve acceptable glycemic control despite the use of intensive insulin therapy and continuous glucose measurement, there exists the possibility of continuous intraperitoneal insulin delivery via an implantable pump or a percutaneous port system that is connected to an external insulin pump. In this article, the current second generation of the Accu-Chek® DiaPort system for continuous intraperitoneal insulin delivery with its improvements over the former generation is presented and discussed.
‘A longitudinal room of possibilities’ – perspectives on the benefits of long-term preventive home visits: A qualitative study of nurses’ experiences
Authors: Tøien Mette , Bjørk Ida Torunn , Fagerström Lisbeth
Published: June 2019

Preventive home visits carried out by healthcare professionals are intended to promote the health and independence of home-dwelling older persons and to prevent functional decline. The aim of this study was to describe nurses’ experiences of the benefits from long-term follow up with annual preventive home visits to older people in a Norwegian context. We conducted semi-structured interviews with nine nurses who performed the service. Manifest and latent content analysis revealed benefits within three themes: sustained ability to live independently and thrive despite age-related changes, eased transition to other healthcare services, and improved healthcare service planning. Two headlines describe the longitudinal processes involved in the creation of benefits: ‘The processes of establishing, sustaining, and widening a longitudinal room of possibilities’, and ‘The individualized health-promoting processes – the ongoing gardening work. Professional, contextual and structural factors influenced the nurses’ ability to support older persons’ changing needs during the aging process and thus their health and independence.
Understanding Customer Repurchase Intention in E-commerce: Role of Perceived Price, Delivery Quality, and Perceived Value
Authors: Ali Asif , Bhasin Jaya
Published: June 2019

In an e-commerce setup understanding the mechanism of repurchase intention of consumers is very essential for survival of business. The main purpose of this study was to understand mechanism and factors that impact consumer repurchase intention. Drawing upon information systems and marketing literature a model was formulated. The model was tested empirically using data collected through online survey in India. A total of 900 links to survey were emailed or messaged out of which 375 responses were received. Out of 375 responses 61 responses were eliminated due to incomplete information or lack of internet shopping experience. A total of 314 responses were finally put to empirical analysis. The findings of this study portray that perceived price and delivery quality have significant impact on perceived value, and perceived value has significant impact on repurchase intention. Further perceived price was found inversely related to perceived value and delivered quality was directly related to perceived value.
Professional Bereavement Photography in the Setting of Perinatal Loss: A Qualitative Analysis
Authors: Ramirez Faustine D. , Bogetz Jori F. , Kufeld Megan , Yee Lynn M.
Published: June 2019

Perinatal loss, including fetal and infant death, is a devastating experience for parents, resulting in long-term adverse physical and psychosocial outcomes. However, little is known about what services might best support grieving parents. We aimed to understand the role of professional bereavement photography in assisting the grieving process of parents who have lost a fetus or infant, by examining the perspectives of bereaved parents, professional photographers, and health care professionals. Twenty semistructured interviews were conducted, and interview transcripts were analyzed using modified grounded theory. Twenty-three individuals participated, including 6 bereaved parents, 8 photographers, and 9 health care professionals. Analyses generated 5 major themes describing ways in which the photographs were valuable to parents: validation of the experience, permission to share, creation of a permanent and tangible legacy, creation of positive memories, and moving forward after the loss. Hospitals should consider incorporation of professional bereavement photography services into palliative care and bereavement programs.
Immigrant Identities and the Shaping of a Racialized American Self
Authors: Sorrell Katherine , Khalsa Simranjit , Ecklund Elaine Howard , Emerson Michael O.
Published: June 2019

Immigration scholars largely focus on adaptation processes of immigrant groups, while race scholars focus on structural barriers nonwhite immigrants face. By comparing nonwhite immigrants with native-born Americans, we can better understand how racial logics affect the identification of racial minorities in the United States. Drawing on 153 interviews with Indian, Caribbean, Chinese, Filipino, and Mexican immigrants, and comparing their narratives to those of black native-born respondents, the authors find similar understandings of American identity across immigrant groups as well as barriers to recognition as American shared by immigrants and native-born blacks. Immigrant narratives continue to reify the United States as a white nation, thus leading to their exclusion by default.
A review of exercise pulmonary hypertension in systemic sclerosis
Authors: Shaikh Faisal , Anklesaria Zafia , Shagroni Tasneam , Saggar Rajeev , Gargani Luna , Bossone Eduardo , Ryan Michael , Channick Richard , Saggar Rajan
Published: June 2019

In general, pulmonary vascular disease has important negative prognostic implications, regardless of the associated condition or underlying mechanism. In this regard, systemic sclerosis is of particular interest as it is the most common connective tissue disease associated with pulmonary hypertension, and a well-recognized at-risk population. In the setting of systemic sclerosis and unexplained dyspnea, the concept of using exercise to probe for underlying pulmonary vascular disease has acquired significant interest. In theory, a diagnosis of systemic sclerosis–associated exercise pulmonary hypertension may allow for earlier therapeutic intervention and a favorable alteration in the natural history of the pulmonary vascular disease. In the context of underlying systemic sclerosis, the purpose of this article is to provide a comprehensive review of the evolving definition of exercise pulmonary hypertension, the current role and methodologies for non-invasive and invasive exercise testing, and the importance of the right ventricle.
Levantite, KCa3(Al2Si3)O11(PO4), a new latiumite-group mineral from the pyrometamorphic rocks of the Hatrurim Basin, Negev Desert, Israel
Authors: Galuskin Evgeny V. , Krüger Biljana , Galuskina Irina O. , Krüger Hannes , Vapnik Yevgeny , Pauluhn Anuschka , Olieric Vincent
Published: June 2019

Levantite, with the end-member formula KCa3(Al2Si3)O11(PO4), is the phosphate analogue of latiumite, KCa3(Al3Si2)O11(SO4, CO3) found in gehlenite–wollastonite hornfels on Har Parsa, Negev Desert, Israel. Levantite forms later zones on long-prismatic crystals of latiumite. Rarer homogeneous colourless levantite crystals up to 0.2 mm long and with mean composition (K0.94Ba0.01Na0.01□0.04)Σ1.00(Ca2.96Mg0.03)Σ2.99{(Si2.69Al2.06Fe3+0.16P0.06)Σ4.97O11}[(PO4)0.65(SO4)0.35]Σ1.00were noted. Minerals of the levantite–latiumite series are associated with gehlenite, wollastonite, clinopyroxene of the esseneite–diopside series, anorthite and Ti-bearing andradite. Levantite crystalises in space groupP21with unit-cell parametersa= 12.1006(9) Å,b= 5.1103(4) Å,c= 10.8252(9) Å, β = 107.237(8)°,V= 639.34(9) Å3andZ= 2. The structure of levantite is analogous to latiumite. It is formed by tetrahedral hybridzweierdouble layers [(Si,Al)10O22] connected by Ca atoms. Three Ca atoms linked to different double layers are bridged over by (PO4) and minor (SO4) groups. K atoms reside in the cavities between two superimposedzweierdouble layers. The measured micro-indentation hardness of levantite gave VHN50= 580(19) (mean of 14), range 550–611 kg/mm2, which correlates with 5 on the Mohs scale. Cleavage is good on (100). Twinning on (100) is polysynthetic or simple. The calculated density is 2.957 g cm–3. Levantite is optically negative with α = 1.608(2), β = 1.618(2), γ = 1.622(2) (λ = 589 nm), 2Vmeas.= 70(5)° and 2Vcalc.= 64.3°. Dispersion of the optical axes r > v is weak; the optical orientation is:Z=b,X^c= 22–27°; and it is non-pleochroic. Minerals of the levantite–latiumite series from Israel show characteristic Raman spectra with the main bands at 994 cm–1[ν1(SO4)2–] and 945 cm–1[ν1(PO4)3–]. The band intensity ν1(PO4)3–/ν1(SO4) ratio is well correlated with P and S contents in the investigated minerals. The strongest lines in the powder diffraction pattern [dobs, Å (I, %) (hkl)] are: 3.0762(100)(310), 2.8551(96)($\bar 2$13), 2.9704(92)($\bar 3$12), 2.8573(83)(013), 2.5552(66)(020), 2.8228(48)(212), 2.8893(40)(400), and 3.0634(30)(103).
USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
Authors: Man Xiaojun , Piao Chiyuan , Lin Xuyong , Kong Chuize , Cui Xiaolu , Jiang Yuanjun
Published: June 2019

Background

USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear.

Methods

q-RT-PCR was performed to examine the expression of miR-130b-3p, miR-301b-3p and USP13 in BC tissue samples. Western blot, q-RT-PCR, bioinformatic analysis and dual-luciferase reporter assay were conducted to identify the regulatory function of miR-130b-3p/301b-3p for USP13. Co-immunoprecipitation assay was performed to assess the interaction between USP13 and PTEN protein. Cell-counting-kit 8, colony formation assay and transwell assay were performed to value the proliferative, migrative and invasive capacities of BC cells in vitro. Mouse xenograft model of BC cells was established to verify the function of USP13 in vivo. Immunohistochemistry was performed to identify the protein expression of USP13, NF-kB p65 or PTEN in clinical/xenograft tumor tissues.

Results

Our present study reveals that USP13 functions as a tumor suppressor by interacting with PTEN protein and increasing its expression in bladder cancer. We found that loss of USP13 led to the downregulation of PTEN and promoted proliferative, invasive and migrative capacities of bladder cancer cells. Furthermore, we discovered that USP13 was a common target of miR-130b-3p and miR-301b-3p, and the miR-130b/301b cluster, which could be transcriptionally upregulated by NF-kB. Our data demonstrated that NF-kB activation decreased expression level of USP13 and PTEN, and promoted the tumorigenesis phenotypes of BC cells. In addition, reintroduction of USP13 partially rescued PTEN expression as well as the oncogenesis trend caused by NF-kB.

Conclusion

We reported a potential regulatory loop that the NF-kB-induced miR-130b/301b overexpression decreased USP13 expression and subsequently resulted in the downregulation of PTEN protein and promoted tumorigenesis of bladder cancer. Moreover, NF-kB-mediated PTEN downregulation is very likely to facilitate the full activation of NF-kB.
Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells
Authors: Rossi Jean‐François , Céballos Patrice , Lu Zhao‐Yang
Published: June 2019

Cancer cell growth is associated with immune surveillance failure. Nowadays, restoring the desired immune response against cancer cells remains a major therapeutic strategy. Due to the recent advances in biological knowledge, efficient therapeutic tools have been developed to support the best bio‐clinical approaches for immune precision therapy. One of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies, particularly the use of rituximab for B‐cell lymphoproliferative disorders. More recently, other monoclonal antibodies have been developed, to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression, or to enhance some immune functions with immune adjuvants through different targets such as Toll‐receptor agonists. The aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse effects. This effect is supported by enhancing the number, functions, and activity of the immune effector cells, including the natural killer (NK) lymphocytes, NKT‐lymphocytes, γδ T‐lymphocytes, cytotoxic T‐lymphocytes, directly or indirectly through vaccines particularly with neoantigens, and by lowering the functions of the immune suppressive cells. Beyond these new therapeutics and their personalized usage, new considerations have to be taken into account, such as epigenetic regulation particularly from microbiota, evaluation of transversal functions, particularly cellular metabolism, and consideration to the clinical consequences at the body level. The aim of this review is to discuss some practical aspects of immune therapy, giving to clinicians the concept of immune effector cells balancing between control and tolerance. Immunological precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.
Circulating Exosomes Activate Dendritic Cells and Induce Unbalanced CD4+ T Cell Differentiation in Hashimoto Thyroiditis
Authors: Cui Xuejiao , Liu Yongping , Wang Shuo , Zhao Na , Qin Jing , Li Yushu , Fan Chenling , Shan Zhongyan , Teng Weiping
Published: June 2019

Objective

This study explored whether circulating exosomes effectively participate in the inflammatory response in Hashimoto thyroiditis (HT).

Design

Exosomes were extracted from the serum of 30 patients with HT and 30 healthy control (HC) subjects. The expression of thyroperoxidase (TPO), thyroglobulin, high mobility group box 1 (HMGB1), heat shock protein 60 (HSP60), major histocompatibility complex class II (MHC-II), and intercellular adhesion molecule 1 (ICAM1) in exosomes was determined by Western blotting. Flow cytometry and immunofluorescence were performed to confirm that exosomes were taken up by healthy peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs). Then, either DCs or PBMCs were stimulated with HT exosomes (serum exosomes from patients with HT) or HC exosomes (serum exosomes from HC subjects) in the presence or absence of Toll-like receptor (TLR)2/3 inhibitors.

Results

TPO, HSP60, and MHC-II expression was higher in HT exosomes than in HC exosomes. Exosomes were mainly taken up by CD14+ monocytes and CD11c+ DCs. After DCs were stimulated by HT exosomes, significant elevations were observed in MyD88, TRIF, and p-P65 expression; median fluorescence intensity of CD40 and CD83; and IL-6 production. After stimulating PBMCs with HT exosomes, CD11c+TLR2+/TLR3+ and CD4+IFN-γ+Th1/IL-17A+Th17A cell percentages were significantly elevated, and CD4+CD25+Foxp3+ Treg cell percentage was significantly decreased. HT exosomes induced increased IL-17A and IFN-γ production, whereas IL-10 production was suppressed. However, addition of TLR2 or TLR3 inhibitor reversed most of the abovementioned results.

Conclusions

Our study demonstrates that HT exosomes can present antigens to DCs and bind TLR2/3, causing DC activation via the nuclear factor κB signaling pathway, leading to an imbalance in CD4+ T lymphocyte differentiation, and potentially contributing to HT onset.
Protestant Buddhism and “Influence”
Authors: Abeysekara Ananda
Published: June 2019

Critiques of the concept of “Protestant Buddhism” claim to tell a different story about the relation between religion and modernity (“Protestantism”) in South Asia. They seek to reconstruct the temporal relation between the past and the present, contesting postcolonial conceptions of history, time, and religious practice. This story of temporality is staked on the question of “influence,” which has a genealogy that includes not just colonial, missionary, liberal politics but also contemporary legal-political questions about foreign influence on democracy and sovereignty. This article argues that preoccupation with influence inscribes an a priori ontology that already separates the past from the present. This makes it difficult to understand the relation between temporality and a form of life in a discursive tradition, as the question of influence grounds the ostensive plurality of religions in some preexisting ontological difference. Once religion as such is understood as an object of influence, the temporality of the form, which is encountered within power—that is, the formations of particular sensibilities and dispositions within the coherence of a tradition—is rendered marginal if not irrelevant to the embodied life of religion. The article calls for renewed attention to the temporality of sensibilities to think about the temporality of a form of life within the limits of a tradition.
Proust’s Natural History Museum
Authors: Crawford Ryan
Published: June 2019

This essay takes the last pages of Marcel Proust’s In Search of Lost Time at its word: at the moment the narrator achieves a definitive conception of the work he intends to write, he sees society composed, not of people of flesh and blood, but of monsters fit for a museum of natural history. As the novel culminates in images and concepts that are essentially nonhuman, inhuman, or posthuman in character, it demonstrates an exacting knowledge of what the present is only now beginning to realize: after two world wars and humanity’s recent entry into what is called the age of the Anthropocene, certain fundamental relations (between subject and object, between nature and history, between past, present, and future) must be rethought to account for both the eclipse of the human as well as nature’s ultimate survival. This essay seeks to develop a philosophical form that would approximate the novel’s discovery of this posthuman natural history.
The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy
Authors: Milenkovic Andrea , Schmied Denise , Tanimoto Naoyuki , Seeliger Mathias W. , Sparrow Janet R. , Weber Bernhard H. F.
Published: June 2019

Human bestrophin-1 (BEST1) is an integral membrane protein known to function as a Ca2+-activated and volume-regulated chloride channel. The majority of disease-associated mutations in BEST1 constitute missense mutations and were shown in-vitro to lead to a reduction in mutant protein half-life causing Best disease (BD), a rare autosomal dominant macular dystrophy. To further delineate BEST1-associated pathology in-vivo and to provide an animal model useful to explore experimental treatment efficacies, we have generated a knock-in mouse line (Best1Y227N). Heterozygous and homozygous mutants revealed no significant ocular abnormalities up to 2 years of age. In contrast, knock-in animals demonstrated a severe phenotype in the male reproductive tract. In heterozygous Best1Y227N males, Best1 protein was significantly reduced in testis and almost absent in homozygous mutant mice, although mRNA transcription of wildtype and knock-in allele is present and similar in quantity. Degradation of mutant Best1 protein in testis was associated with adverse effects on sperm motility and the capability to fertilize eggs. Based on these results, we conclude that mice carrying the Best1 Y227N mutation reveal a reproducible pathologic phenotype and thus provide a valuable in-vivo tool to evaluate efficacy of drug therapies aimed at restoring Best1 protein stability and function.
Prelacteal feeding practice and maintenance of exclusive breast feeding in Bihar, India – identifying key demographic sections for childhood nutrition interventions: a cross-sectional study
Authors: Das Aritra , Sai Mala Guntur , Singh Ram Shankar , Majumdar Amlan , Chatterjee Rahul , Chaudhuri Indrajit , Mahapatra Tanmay
Published: June 2019

Background:  Exclusive breastfeeding (EBF) during the first six months of life is considered a high impact, but low-cost, measure for improving nutritional status, and reducing morbidity and mortality among children. However, providing prelacteal feed to a newborn, a widely practiced custom in rural India, is a major barrier to the practice of EBF.  The present study evaluated the association between provision of prelacteal feeding and continuation of EBF among children up to 3 months age in Bihar, a resource-poor Indian state.

Methods: Data from four rounds of a population-based multi-stage sampling survey, conducted in 8 districts of Bihar between 2012 and 2013, were used for the present analysis. Using simple and adjusted logistic regression modelling, we tested the association of providing prelacteal feeding with two outcome measures - 1) giving only breastmilk during the last 24 hours, and 2) exclusively breastfed (EBF) since birth (excluding the first 3 days of life).

Results: Among 10,262 children for whom prelacteal feeding data was available, 26% received prelacteal feeding. About 55% mothers reported that their children were exclusively breastfed, whereas 82% mothers provided only breastmilk to their children during the previous 24 hours. Children who received prelacteal feeding had approximately 60% lesser odds of being breastfed exclusively during the previous 24 hours [AOR = 0.39(0.33-0.47)] and 80% lesser odds of receiving continued EBF since birth [AOR = 0.20(0.17-0.24)].

Conclusions: Frontline workers (FLW) provide nutritional counselling to mothers and children of rural India. In order to improve uptake of EBF, the families practicing prelacteal feeding should be identified early and educated on the harmful effects of prelacteal feeding for EBF and subsequently on infant health. Midwives/nurses at the public and private facilities as well as the home birth attendants should also be made aware about the negative effects of prelacteal feed.
Drowning in the Beauty of the Lord: A Glimpse at the Medieval Śrīvaiṣṇava Commentators’ Interpretation of the pādādi-keśa-varṇana of Tiruppāṇ Āḻvār’s Amalaṉātipirān
Authors: Suganya Anandakichenin
Published: June 2019

This article explores how three medieval Śrīvaiṣṇava commentators— Periyavāccāṉ Piḷḷai (13th c.), Aḻakiya Maṇavāḷa Perumāḷ Nāyaṉār (14th c.) and Vedānta Deśikaṉ (14th c.)—deal with the passages that describe the different body parts of Raṅganātha, the main Deity in Śrīraṅgam, in Tiruppāṇ Āḻvār’s (9th c.) set of ten verses. Known as Amalaṉātipirāṉ (AAP),1 this decade, now part of the Nālāyira Tivviyap Pirapantam (or Nālāyira Divya Prabandham), follows the eyes of the poet, as they gradually move from the Deity’s foot to His head. The commentators make the most of these descriptions in order to emphasize the importance of beauty, which is visible, hence accessible, to everyone in His arcā (‘sacred icon’2) form and which is inextricably linked to His other attributes like sovereignty.
The Missionaries in the Race for Putting the Veda to Print
Authors: Cezary Galewicz
Published: June 2019

The early 1800s saw several competing projects of opening the hitherto guarded textuality of the Veda to a wider public, both in Europe and in India. Apart from those animated by the spirit of imperial control or allegedly pure academic interest, others situated themselves within broader goals of the new wave of missionary work in India. Among the Protestant missionaries to take active part in projects of that sort, the exceptional figure of Rev. John Stevenson of the Church of Scotland stands conspicuously unparalleled. The paper intends to follow the circumstances of the publishing and to offer an idea about the complex ideology that might have accompanied Stevenson’s pioneering work in editing and translating of the Veda, especially his work titled The Threefold Science that appeared in 1833 in Bombay.
„O powszechną płci naszej chwałę”: Tłumaczki epoki stanisławowskiej
Authors: Dębska Karolina
Published: June 2019

“For the Universal Glory of Our Sex”: Women Translators in the Times of King Stanisław August This article presents women translators in Poland in the years of the reign of King Stanisław August Poniatowski (1763-1795) in order to establish who they were, what they translated and why, as well as sketch their collective profile and its impact on their translatorial practice.
Jak (wy)tłumaczyć punkt widzenia kota?
Authors: Jeleń Krzysztof
Published: June 2019

How to Explain a Cat’s Viewpoint? (On Russian Translations of Wisława Szymborska’s Poem Cat in an Empty Apartment)

This paper deals with some difficulties related to Russian translations of Wisława Szymborska’s poem Cat in an empty apartment. The question of presence and visibility of lyrical subject in the original text and its translations is one of the major issues presented in the article. An analysis of N. Astafiewa’s and N. Gorbaniewska’s tranlations has been conducted with special respect to the agentivity phenomenon on the level of verb forms. Linguistic categorization has also been mentioned. The author tries to present how differently Russian translators, who perform their typical role of poetry translators, strive for faithfulness of form and content of the original text and in what manner their solutions can influence the lyrical subject’s viewpoint.
Bi-objective Branch-and-Cut Algorithms Based on LP Relaxation and Bound Sets
Authors: Gadegaard Sune Lauth , Nielsen Lars Relund , Ehrgott Matthias
Published: June 2019

Most real-world optimization problems are multi-objective by nature, with conflicting and incomparable objectives. Solving a multi-objective optimization problem requires a method that can generate all rational compromises between the objectives. This paper proposes two distinct bound set-based branch-and-cut algorithms for general bi-objective combinatorial optimization problems based on implicit and explicit lower-bound sets. The algorithm based on explicit lower-bound sets computes, for each branching node, a lower-bound set and compares it with an upper-bound set. The other fathoms branching nodes by generating a single point on the lower-bound set for each local nadir point. We outline several approaches for fathoming branching nodes, and we propose an updating scheme for the lower-bound sets that prevents us from solving the bi-objective linear programming relaxation of each branching node. To strengthen the lower-bound sets, we propose a bi-objective cutting-plane algorithm that adjusts the weights of the objective functions such that different parts of the feasible set are strengthened by cutting planes. In addition, we suggest an extension of the branching strategy “Pareto branching.” We prove the effectiveness of the algorithms through extensive computational results.
One Step Forward, Two Steps Back: How Negative External Evaluations Can Shorten Organizational Time Horizons
Authors: DesJardine Mark , Bansal Pratima
Published: June 2019

Researchers have endeavored to explain the causes of short organizational time horizons because of the organizational and societal costs of corporate short-termism. These explanations, however, tend to confound cognitive with behavioral explanations, which masks the importance of cognitive biases. We address this oversight by situating our work in prospect theory and organizational search, which underscores the importance of external evaluations on organizational time horizons and the asymmetry of positive and negative evaluations. Specifically, we argue that negative evaluations will shorten organizational time horizons more than positive evaluations will lengthen them. In our research context of financial analysts, this means that “sell” recommendations will shorten time horizons more than “buy” recommendations will lengthen them. Our main thesis can help to explain rising short-termism among some publicly traded companies. We operationalize organizational time horizons by the language managers use during 3,136 quarterly earnings conference calls. We test our main hypothesis and other timing-related moderating effects on 98 extractives firms from 2006 to 2013.
Optimal Control of Markov-Modulated Multiclass Many-Server Queues
Authors: Arapostathis Ari , Das Anirban , Pang Guodong , Zheng Yi
Published: June 2019

We study multiclass many-server queues for which the arrival, service, and abandonment rates are all modulated by a common finite-state Markov process. We assume that the system operates in the “averaged” Halfin–Whitt regime, which means that it is critically loaded in the average sense although not necessarily in each state of the Markov process. We show that, under any static priority policy, the Markov-modulated diffusion-scaled queueing process is exponentially ergodic. This is accomplished by employing a solution to an associated Poisson equation to construct a suitable Lyapunov function. We establish a functional central limit theorem for the diffusion-scaled queueing process and show that the limiting process is a controlled diffusion with piecewise linear drift and constant covariance matrix. We address the infinite-horizon discounted and long-run average (ergodic) optimal control problems and establish asymptotic optimality.
Integrated Shift Scheduling and Load Assignment Optimization for Attended Home Delivery
Authors: Restrepo María I. , Semet Frédéric , Pocreau Thomas
Published: June 2019

In this article, we study an integrated shift scheduling and load assignment optimization problem for attended home delivery. The proposed approach is divided into two phases, each one corresponding to a different planning level: tactical and operational. In the tactical planning, a daily master plan is generated for each courier. This master plan defines the working shifts, the origin–destination pairs to visit, and the number of client requests to serve. In the operational planning, delivery orders are allocated to couriers in real time. The stochastic and dynamic nature of client orders is included in the tactical and operational decision levels, respectively. Experimental results demonstrate that our approach provides robust tactical solutions that easily accommodate fluctuations in client orders, preventing additional costs related to the underutilization of couriers and to the use of external couriers to satisfy all delivery requests, when compared with an approach using the mean demand value. Moreover, these results also indicate that the failure to incorporate robust tactical solutions in the operational planning results in infeasible operational plans that are inadmissible regarding the couriers’ working time (e.g., minimum and maximum numbers of working hours) and work regulations (e.g., allocation of consecutive working hours to the couriers).
O tema da subjetividade e os limites da história: uma leitura de Sartre a partir de suas influências kierkegaardianas
Authors: De Paula Marcio Gimenes
Published: June 2019

O objetivo do presente artigo é avaliar, a partir de pequenos e selecionados fragmentos da obra de Sartre, a presença do tema da subjetividade e a crítica ao conceito de história tal como pensado por Kierkegaard. Para tanto, o trabalho será delimitado em três pontos: o primeiro almeja avaliar tais questões a partir de menções explicitas a Kierkegaard feitas em O Ser e o Nada e também em dois pequenos textos do pensador francês, a saber, O existencialismo é um humanismo e O universal singular. O segundo ponto do trabalho avaliará o tema da subjetividade e da crítica da história em fragmentos selecionados da obra de Kierkegaard, tais como, O Conceito de angústia, Migalhas filosóficas e o Pós-Escrito às Migalhas filosóficas. Já o problema do eu pensado por Kierkegaard - e posteriormente por Sartre – será retomado na terceira divisão do artigo e, nesse sentido, o foco principal aqui se concentrará na obra A Doença para a Morte. Por fim, concluiremos o trabalho investigando qual era o Kierkegaard conhecido por Sartre, seus limites e perspectivas.
Contribuições de uma teoria da consciência irrefletida para uma filosofia da liberdade a partir de A transcendência do Ego
Authors: Guimarães Deborah Moreira
Published: June 2019

O propósito desse artigo é explicitar os aspectos fundamentais acerca da teoria da consciência desenvolvida por Sartre em A transcendência do Egono âmbito da passagem de seu projeto fenomenológico ao seu projeto ético. Partiremos da dicotomia entre “consciência e mundo” a fim de alcançarmos a distinção da consciência em níveis, o que será de extrema importância para se compreender o propósito ético que também envolve a interpretação da constituição egoica humana em sua relação com a condição de ser-no-mundo.
Survival rates of resin composite restorations in loadbearing situations in posterior teeth
Authors: Burke F J Trevor , Mackenzie Louis , Shortall Adrian CC
Published: June 2019

The use of resin composite for routine restoration of cavities in posterior teeth is now commonplace, and will increase further following the Minamata Agreement and patient requests for tooth-coloured restorations in their posterior teeth. It is therefore relevant to evaluate the published survival rates of such restorations. A Medline search identified 144 possible studies, this being reduced to 24 when inclusion criteria were introduced. Of these, ten directly compared amalgam and composite, eight were cohort studies, and six were systematic reviews. It was concluded that posterior composites may provide restorations of satisfactory longevity and with survival rates generally similar to those published on amalgam restorations. However, the ability of the operator in placing the restoration may have a profound effect.

CPD/Clinical Relevance: With the increasing use of composite for restorations in posterior teeth, it is relevant to note that these may provide good rates for survival.
Kids at heart?: Exploring the material cultures of adult fans of all-ages animated shows
Authors: Maier Kodi
Published: June 2019

Currently, the animated television series is a largely child-oriented medium, with occasional exceptions such as South Park (1997–present), Family Guy (1999–present) or the shows broadcast on Cartoon Network’s adultsonly programming block [adult swim]. Because of this, television animation merchandise is primarily aimed at children, with a plethora of toys, clothing and other items available for a variety of shows. For series such as the first iteration of The Powerpuff Girls (1998–2005) or, more recently, My Little Pony: Friendship is Magic (2010–19), producers and creators have been aware that adult audiences exist but floundered in creating adult-oriented merchandise. However, this attitude seems to be shifting: shows such as Adventure Time (2010–18) and Steven Universe (2013–present) have massive, multigenerational appeal and Cartoon Network has happily embraced the series’ adult fans, aiming a number of merchandising programmes specifically at them. This article will explore the material cultures of television through the adult fans’ relationship to the merchandise of their favourite animated shows, first by discussing what merchandise, if any, television networks create for adults, and going on to theorize that such merchandise is a significant outlet in adults’ persisting need for play.
In vivo approach on femur bone regeneration of white rat (Rattus norvegicus) with the use of hydroxyapatite from cuttlefish bone (Sepia spp.) as bone filler
Authors: Aminatun Aminatun , Handayani D.E. Fadhilah , Widiyanti Prihartini , Winarni Dwi , Siswanto Siswanto
Published: June 2019

Background: Hydroxyapatite (HA) from bovine bone has been widely used as bone filler in many fractures cases. HA can also be made from cuttlefish bone (Sepia spp.) that has abundant availability in Indonesia and contains 84% CaCO3, which is a basic ingredient of HA. However, research on the effects of HA from cuttlefish bone on bone regeneration parameters has not been done yet. Aim: This study aimed to determine femur bone regeneration of white rats (Rattus norvegicus) through the use of HA from cuttlefish bone (Sepia spp.) as bone filler. Materials and Methods: HA was made using the hydrothermal method by mixing 1M aragonite (CaCO3) from cuttlefish bone and 0.6 M NH4H2PO4 at 200°C for 12 h followed by sintering at 900°C for 1 h. In vivo test was carried out in three groups, including control group, bovine bone-derived HA group, and cuttlefish bone-derived HA group. The generation of femur bone was observed through the number of osteoblasts, osteoclasts, woven bone, lamellar bone, havers system, and repair bone through anatomical pathology test for 28 days and 56 days. Results: Anatomical pathology test results are showed that administration of bovine bone-derived HA and cuttlefish bone-derived HA increased the number of osteoblasts, osteoclasts, woven bone, lamellar bone, havers system, and bone repair at recuperation of 56 days. Statistical test using Statistical Package for the Social Sciences with Kruskal–Wallis and Mann–Whitney U-test was resulted in significant differences between the bovine bone-derived HA control group and the cuttlefish-derived HA control group. There was no significant difference toward the indication of bone formation through the growth of osteoblasts, osteoclasts, woven bone, lamellar bone, havers system, and bone repair in the bovine bone-derived HA and cuttlefish bone-derived HA groups. Conclusion: It can be concluded that cuttlefish bone-derived HA has the potential as bone filler based on the characteristics of bone regeneration through in vivo test.
Heilsame Architektur
Authors: Brichetti Katharina , Mechsner Franz
Published: June 2019

»Healing Design«, »Architecture for Health«, »Urban Health« - immer lauter wird der Ruf nach Bauten, die nicht nur funktional gestaltet sind, sondern so, dass Menschen sich in ihnen wohlfühlen und besser gesund werden: nach Architekturen also, welche die Gesetzmäßigkeiten des leiblich-räumlichen Wahrnehmens und Spürens berücksichtigen. Katharina Brichetti und Franz Mechsner stellen Projekte heilsamer Architektur vor und verbinden dies mit Einsichten aus Psychologie, Neurobiologie und Phänomenologie, um zu zeigen, was menschenfreundliche Raumgestaltung ausmacht. Im Mittelpunkt steht dabei die Wirkung gebauter Umwelt auf das Erleben im Sinne einer »Rehumanisierung von Architektur« (Gernot Böhme).
Trazos de sangre y fuego
Authors: Valenzuela Arce José Manuel
Published: June 2019

En estos tiempos se han acentuado los procesos de pobreza y desigualdad social, así como los escenarios de violencia y muerte que involucran a las personas, al planeta y a la vida misma. Los rasgos destructores del orden capitalista internacional tardío han colocado a la relación vida-muerte en el centro de la discusión social, humanista, ecológica y artística. Este libro invita a repensar el mundo contemporáneo a través de la discusión sobre biopolítica, necropolítica, juvenicidio y narcocultura, y ofrece un análisis de la conformación de los rasgos que enfatizan las desigualdades, distintivos de algunos sectores de las clases media y alta.
Dismantle Imperia
Authors: Smith Robyn
Published: June 2019

These character designs and comics pages are from a larger project focused on critically and creatively de-centering whiteness as a standard of heroism. The bodies of superheroes, have for so long been created to look like those of white men, conflating ideas of perfection and power with their images. My drawings portray a historically informed league of superheroes to directly confront the stereotypes and lack of complexity around the construction of Black superheroes. They are centered around the historical figure, Nanny of the Maroons, a National Heroine of Jamaica, while also drawing on other histories and myths aligned with Caribbean slave rebellions, their leaders and the larger transatlantic slave trade. I have created this league not only to physically/ visually represent Black people but also represent them historically. I have created these heroes for the marginalised whose identities and experiences aren't fully substantiated.
Inglés en tiempos de CLIL: propuesta para una nueva metodología para las clases de inglés
Authors: Halbach Ana
Published: June 2019

“Hemos encontrado el libro de texto ideal este año. No hay nada que mejorar”. Así me contestó una alumna del máster, profesora de primaria en un centro bilingüe, a la que le acababa de proponer que llevara a cabo un proyecto de trabajo con textos en su clase de inglés. Un par de meses más tarde, hecha la experiencia, no querían saber nada del libro de texto ni ella ni sus alumnos. CLIL pide a gritos un cambio metodológico —también en las clases de inglés—.
Auxiliares de conversación: una oportunidad para desarrollar la competencia intercultural en el aula
Authors: Buckingham Lyndsay R.
Published: June 2019

El auxiliar de conversación puede ser una ayuda imprescindible a la hora de desarrollar las destrezas orales en la lengua extranjera. Pero también ofrece la posibilidad a nuestros alumnos de convertirse en ciudadanos globales. La experiencia de conversar y colaborar con el auxiliar les ayuda a desarrollar la competencia intercultural, una competencia imprescindible hoy en día.
Los retos del docente AICLE
Authors: Custodio Espinar Magdalena
Published: June 2019

AICLE es mucho más que enseñar en inglés, porque enseñar en un idioma extranjero no es lo mismo que enseñar un idioma extranjero, ni lo mismo que enseñar en la lengua materna. Un buen nivel de inglés de los docentes no es una garantía de una enseñanza bilingüe de calidad. La formación metodológica en AICLE es fundamental para promover un aprendizaje lingüístico y cognitivo adecuado a las necesidades de cada alumno. Por tanto, es uno de los retos más importantes de la educación bilingüe para garantizar su sostenibilidad a largo plazo.
Alessandro Valignano: educación, inculturación y adaptación en Japón
Authors: Jiménez Pablo Esther
Published: June 2019

La figura del jesuita Alessandro Valignano como maestro y visitador de las misiones de las Indias Orientales nos permite conocer un nuevo método de evangelizar en Japón a finales del s. XVI y principios del s. XVII. Lejos de irrumpir en la cultura receptora, Valignano trató de que los misioneros jesuitas dialogaran interculturalmente, adaptando las creencias cristianas al estilo de vida japonés.
The Contemporary Contours of Imperialism
Authors: Gupta Chirashree
Published: June 2019

Situated largely within the Marxist debates on imperialism—but addressing the liberal formulations too—The Changing Face of Imperialism: Colonialism to Contemporary Capitalism is an important intervention regarding the material basis of imperialism and its three-hundred-year-old history of unequal power relations. The book broadly addresses five issues: (1) the nature of finance capital and the novel yet familiar processes of value extraction; (2) the world of capital; (3) global production networks and labor regimes; (4) the institutional system of nation-states in the new global order; and (5) the nature of integration from colonial regimes to now.
Literacidad digital y académica: contraste preliminar entre dos universidades
Authors: Casanovas Catalá Montserrat , Capdevila Tomás Yolanda , Ciro Lirian Astrid
Published: June 2019

Este artículo se deriva de una investigación que pretende examinar las prácticas de construcción de textos académicos de estudiantes universitarios a partir del análisis de los recursos y herramientas digitales que utilizan en la redacción de sus composiciones. Para establecer un diagnóstico preliminar, se presentan algunos resultados de un cuestionario piloto aplicado en la Universidad de Lleida (España) y en la Universidad del Valle (Colombia). Este estudio es cualitativo con enfoque descriptivo. En este marco, se analizan algunas respuestas relacionadas con el perfil tecnológico y el empleo de herramientas web 2.0 en la escritura académica. El análisis preliminar de los datos permite observar ciertas lagunas competenciales en el manejo académico de la tecnología. Por tanto, se considera necesario tener en cuenta en la formación de los futuros maestros las competencias digitales académicas, tanto en lo correspondiente a aspectos técnicos, como críticos y didácticos. En definitiva, se ofrece un panorama muy general en torno al acercamiento a la lengua escrita de las nuevas generaciones.