bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunocytochemical Assessment of ACE2 and TMPRSS2 in Nasopharyngeal Swabs from SARS-CoV-2 Patients
Authors: Peña Karla Beatríz , Gumà Josep , Guilarte Carmen , Delamo Lola , Grifol Marc , Pique Berta , Hernandez Anna , Casteñé Helena , Riu Francesc , Parada David
Published: July 2022

Background: SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is enveloped by four structural proteins. The entry of the virus into the host cells is mediated by spike protein binding to the angiotensin converting enzyme 2 (ACE2) and proteolytic cleavage by transmembrane protease serine 2 (TMPRSS2). In this study, we analyzed the expression of the ACE2 receptor and TMPRSS2 in cases under investigation for SARS-CoV-2 infection. Methods: The study was carried out using the viral transport medium of consecutive nasopharyngeal swabs from 300 people under examination for SARS-CoV-2 infection. All samples underwent the SARS-CoV-2 transcriptase-mediated amplification assay (Procleix® SARS-CoV-2) to detect the virus. Immunocytochemistry was used in each sample to detect the presence of the SARS-CoV-2 nucleoprotein, the ACE2 receptor, and TMPRSS2. Results: An immunocytochemical study with monoclonal antibody against SARS-CoV-2 viral nucleoprotein showed positivity in squamous cells. ACE2 were not detected in the squamous cells obtained from the nasopharyngeal samples. Conclusions: SARS-CoV-2 predominantly localizes to squamous cells in cytology samples of patients with positive transcriptase-mediated amplification SARS-CoV-2 assay results. The immunocytochemical negativity for ACE2 evidenced in the present study could be related to the cellular heterogeneity present in the nasopharyngeal smear samples and could be related to variations at the genomic level. Our results suggest that SARS-CoV-2 might be present in the nasopharyngeal region because viral cell junctions are weaker. This facilitates viral concentration, infective capacity and migration to specific organs, where SARS-CoV-2 infects target cells by binding to their receptors and then entering.
TAX AUDIT QUALITY: AN EMPIRICAL ANALYSIS OF THE USE OF INFORMATION TECHNOLOGY, COMPETENCE, TASK COMPLEXITY AND TIME PRESSURE
Authors: Nugrahanto Arif , Alhadi Iqbal
Published: July 2022

One of strategies conducted by tax authority to fulfil its tax revenue target is improving audit quality. To do so, this research was designed to analyze the empirical evidence related to factors in the use of information technology, tax auditor’s competencies, task complexity, and time pressure that could potentially affect the quality of tax audit. The research was carried out by using an online survey followed by 96 tax auditors in Tax Offices in the Special Jakarta Region, with fifteen years of tax audit experience on average. The research data were analyzed by using Partial Least Square-Structural Equation Modeling procedures. The results indicate that the factors of information technology in terms of usefulness, ease of use of technology, and support of technological resources are positively associated with tax audit quality. Tax auditor’s competencies in the aspects of knowledge and skills also indicate positive relations. Meanwhile, the factors in time pressure that could deter the evaluation of evidence, implementing procedures, and detection of tax non-compliance have negative consequences on tax audit quality. The implications of these findings for tax authorities are the urgency in improving information technology that keeps pace with the latest business process to support tax audit, improving tax auditors’ competencies continuously, and managing tax audit time
HIT RATE PEMERIKSAAN BARANG BAWAAN PENUMPANG: PENDEKATAN DATA MINING
Authors: Yolanda Agatha Sanggra , Nurkhamid Muh
Published: July 2022

Hit rate pengawasan bawaan penumpang adalah indikator untuk mengetahui jumlah pemeriksaan barang bawaan penumpang yang menghasilkan temuan. Target hit rate pemeriksaan barang bawaan penumpang sebesar 1% pada tahun 2020 dan 1,5% pada 2021 masih jauh dibandingkan dengan hit rate pemeriksaan barang bawaan penumpang di beberapa negara Eropa yang bervariasi dari 1,6% sampai dengan 60%, bahkan pada beberapa negara lain telah menetapkan target diatas 85%. Dengan metode kualitatif, penelitian di KPPBC Tipe Madya Pabean Juanda ini bertujuan untuk merancang model regresi linear dan model klasifikasi dengan data mining sehingga dapat meningkatkan hit rate pemeriksaan barang bawaan penumpang. Penggunaan data mining terbukti dapat memberikan gambaran, proyeksi, dan peningkatan Indikator Kinerja Utama persentase hit rate pemeriksaan barang bawaan penumpang. Dengan akurasi prediksi persamaan linear sebesar 73,44% dan skor Mean Absolute Percentage Error (MAPE) sebesar 26,566%, menyatakan metode prediksi dalam penelitian ini layak digunakan. Penelitian ini diharapkan memberikan alternatif bagi Direktorat Jenderal Bea dan Cukai tentang penggunaan algoritma dalam data mining untuk menentukan target IKU hit rate pemeriksaan barang bawaan penumpang pada periode-periode selanjutnya.

 

Kata Kunci: Data mining, MAPE, hit rate, pemeriksaan, penumpang.
Pterional Approach: Technical Variations, Functional, and Cosmetic Outcome in a Series of 1000 Patients
Authors: Luzzi Sabino , Giotta Lucifero Alice , Baldoncini Matías , Campero Alvaro , Elbabaa Samer K. , Galzio Renato
Published: July 2022

INTRODUCTION
Most of the versatility of the pterional approach depends on a series of variations progressively reported by several groups, but little emphasized over the years.
The present study condenses the technical notes which the authors adopted in their practice to maximize the surgical freedom of the pterional approach, at once lessening the approach-related complication rate.
METHODS
Data of a series of patients who underwent a pterional approach between January 2011 and May 2021 were retrospectively reviewed focusing on the technical variations compared to the original Yaşargil’s description. The anatomical rationale, technique, and advantages were outlined and validated through the appraisal of functional and cosmetic complications.   
RESULTS
994 patients were reviewed. Head extension was avoided in the case of anterior clinoidectomy. A single double-layered galea-pericranium flap was used for duraplasty. The submuscular technique, with compulsive preservation of deep temporal fascia and deep temporal arteries, was preferred for temporalis muscle dissection. McCarty keyhole was never used, thus avoiding exposing the orbit if unnecessary. Widening of the superior orbital fissure and thinning of the orbital roof allowed to significantly increase the working area. The average follow-up was 7.2 years. The overall rate of functional and cosmetic complications was 2.1.
DISCUSSION
In the authors' experience, the gradual adoption of technical variations related to the patient's positioning, soft tissue dissection, bony work, dura opening, and reconstruction allowed to enhance the versatility of the pterional approach concurrently decreasing the risk of functional and cosmetic complications.
"Computer science invents nothing" (historiography V:2 - part two)
Authors: Akmut Camille
Published: July 2022

Computer science and technology :historiography V (2 - part two). Banned video games (works in general), a copyright legal case, Uber early history ...
SMS Based Gas Leakage and Fire Detection Alert System
Authors: Latif Maria , Asad Jazba , Nawaz Faiza , Mazher Noman
Published: July 2022

Safety is the foremost aspect intoday‟s world. In this world of technology,people need technology to help them indanger conditions. Gas leakage becomes asevere issue that results in many accidentswhich lead to mortal and monetary harm. Itis need of hour to install the gas leakagedetection systems on public places. Thispaper presents a system design thatidentifies the leakage of gas and warns theuser about the situation by sending SMS onuser‟s phone with the help of GSM. Smartkitchen by means of IOT is aimed, createdand verified. Our system has more featuresthan existing systems because those weremanual while our system is automatic andprovides rapid reply and correctidentification that can save many lives andprevents humans from many hazardouscases.
Cơ chế mindsponge – Wikipedia tiếng Việt
Authors: Nguyen Van-Quang
Published: July 2022

Cơ chế mindsponge (tiếng Anh là mindsponge mechanism) là học thuyết dùng để giải thích quá trình nạp xả thông tin của tư duy con người (hay tập thể), qua đó giúp lý giải tâm lý và hành vi của con người (hay tập thể). Thuật ngữ mindsponge đến từ phép ẩn dụ rằng tâm trí và tư duy con người (tiếng Anh là mind) tương tự như một miếng bọt biển (tiếng Anh là sponge) có khả năng hấp thụ các giá trị tương thích mới và loại bỏ các giá trị không tương thích với các giá trị cốt lõi của nó. ***** Chỉ dành cho mục đích lưu trữ thông tin *****
Mineral Import Demand and Clean Energy Transitions in the Top Mineral Importing Countries
Authors: Islam Monirul , Sohag Kazi , Alam Md. Mahmudul
Published: July 2022

The clean energy transitions require a large volume of minerals to handle its diverse technologies, such as solar photovoltaics (PV), wind turbines etc. Therefore, mineral importing countries concentrated on cleaner energy production confront an uprising trend in critical mineral prices due to thriving demands. We quest for the response of the top mineral importing countries' import demand for minerals to the clean energy transitions from 1996 to 2019 within the import-demand function analysis. Using the cross-sectional autoregressive distributed lag (CS-ARDL) method, our findings divulge a significantly positive response of mineral import demand to solar and wind energy productions in the long run. We also find that mineral price elasticity holds the Marshallian demand hypothesis in the mineral-laden solar energy generation while contradicting it in wind energy production. In addition, the oil price substitution effect does not sustain, whereas exchange rate depreciates mineral import demands in the long run. Therefore, our policy implications encompass optimizing the mineral resources for clean energy transitions to materialize the 21st century's global agenda of a decarbonized or net-zero emissions trajectory.
TINJAUN K3 PADA PROYEK REKONSTRUKSI/PENINGKATA STRUKTUR JALAN KOTA PALOPO
Authors: Ardi
Published: July 2022

Paper ini bertujuan untuk meninjau aspek kesehatan dan keselamatan pekerja pada proyek Rekonstruksi/peningkatan Kapasitas Struktur jalan di Kota Palopo yang berlokasi di Jalan Andi Kasi Radja VI. Focus utamanya adalah pekerjaan-pekerjaan konstruksi. Paper ini merupakan tugas mata kuliah K3 dan Undang-undang perubahan.
Khái niệm (hiện tượng) cộng tính văn hóa
Authors: Lai Thuong
Published: July 2022

Cộng tính văn hóa (tiếng Anh là cultural additivity, tiếng Hoa là 文化可加性) là khái niệm mô tả cộng đồng (hoặc cá nhân) thuộc một văn hóa xác định sẵn sàng chấp nhận các hệ giá trị của văn hóa khác vào hệ giá trị của cộng đồng (hoặc cá nhân) đó, bất chấp việc các giá trị mới có thể đối nghịch với hệ giá trị đang tồn tại.
Identifying factors leading to delays in diagnosis of endometriosis: a scoping review protocol
Authors: Fryer Jodie , Mason-Jones Amanda J. , Woodward Amie
Published: July 2022

Despite endometriosis being a severe and debilitating disease, with consequences on women’s physical and psychological state, delays in diagnosis remain unchanged over the past 30 years. To date, delays and consequences of the delays have sparsely been evaluated and often, academic papers choose to focus on one specific factor relating to diagnostic delay. This is problematic as individual factors relating to delays are evaluated in isolation, without consideration that throughout the journey to diagnosis, one delay may impact the next. Though delays in diagnosis have been captured, they have not yet been compiled into a single comprehensive document which explicitly outlines each factor contributing to delays. Due to this, this scoping review will identify contributing factors to delays in diagnosis, determine whether they are being addressed and assess whether delays can be improved.
Personality Maturation through Sense of Mastery? Longitudinal Evidence from two Education-to-Work Transition Studies
Authors: Reitz Anne K. , den Boer Liselotte , van Scheppingen Manon A. , Diwan Ketaki
Published: July 2022

Objective: Why personality changes in young adulthood remains a critical theoretical and empirical question. We studied personality change during the education-to-work transition, including (1) the specific timing of personality change, (2) the degree of individual variability in change, and (3) the link between sense of mastery and personality change. Methods: We used data from two intensive longitudinal studies. Study 1 included 5 waves of data across 2 years during the university-to-work transition (N=309; mean-aged 25). Study 2 included 3 waves of data across 8 months during an internship-heavy teacher education program (N=317; mean-aged 22). We assessed personality traits and personality states and work-related and general sense of mastery using questionnaires and experience sampling.Results: First, we found no evidence for mean-level personality maturation. Second, young adults differed significantly in change of personality traits and aggregated states. Third, young adults with higher levels of work-related sense of mastery showed more positive changes in trait Conscientiousness. Decreases in general sense of mastery predicted later decreases in state Emotional Stability and vice versa. Change in general sense of mastery correlated with personality change. Conclusions: Sense of mastery seems to be part of a dynamic short-term process underlying personality change in young adulthood.
Minority stress and positive identity aspects in members of LGBTQ+ parent families: Study protocol for a mixed-methods systematic review and meta-analysis
Authors: Siegel Magdalena , Legler Muriel , Neziraj Fortese , Goldberg Abbie E. , Zemp Martina
Published: July 2022

Background: Parents and children in LGBTQ+ parent families face unique stressors (i.e., minority stress), but also possess unique resources (i.e., positive identity aspects) related to their family identity. Empirical evidence and theory suggest that these minority stressors and positive identity aspects are situated on the individual-, couple-, and family-level and may be associated with key outcomes, including parent and child health, family functioning, and school-related outcomes. A systematic evidence synthesis and a theoretical placement are currently lacking. The aims of the systematic review outlined in this protocol are thus to (1) map minority stressors and positive identity aspects according to multiple levels in the family system, and (2) to synthesize evidence on their associations with key outcomes. Methods: We will conduct a PRISMA-conform mixed-methods systematic review. Studies will be retrieved using a multi-tiered search strategy, including database searches (PsycInfo, PubMed, Scopus, Web of Science), cited literature searches, authors’ publication lists, and study requests. Mixed-methods synthesis will follow a parallel-results convergent synthesis design, where quantitative results will be synthesized via meta-analysis and qualitative results via thematic synthesis. Conclusions: Our proposed systematic review may add to the theoretical understanding of LGBTQ+ parent family functioning and advance social inclusion of LGBTQ+ parent families.
Psychometric evaluation of a visual interpersonal analogue scale
Authors: Woods William C. , Edershile Elizabeth A. , Sharpe Brinkley M. , Ringwald Whitney R. , Himmelstein Philip H. , Newman Michelle G. , Wilson Stephen Jeffrey , Ellison William D. , Levy Kenneth N. , Pincus Aaron L. , Creswell J. David , Wright Aidan G.C.
Published: July 2022

Interpersonal theory organizes social behavior along dominant (vs. submissive) and warm (vs. cold) dimensions. There is a growing interest in assessing these behaviors in naturalistic settings to maximize ecological validity and to study dynamic social processes. Studies that have assessed interpersonal behavior in daily life have primarily relied on behavioral checklists. Although checklists have advantages, they are discrepant with techniques used to capture constructs typically assessed alongside warmth and dominance, such as affect, which typically rely on adjective descriptors. Further, these checklists are distinct from the methodologies used at the dispositional level, such as personality inventories, which rarely rely on behavioral checklists. The current study evaluates the psychometric performance of interpersonal adjectives presented on a visual analogue scale in five different samples. Validity of the visual interpersonal analogue scale (VIAS) approach to momentary assessment was evaluated by comparing its performance with an interpersonal behavior checklist and by examining associations among the VIAS warmth and dominance scales and other momentary and dispositional constructs. Results were generally consistent with an existing interpersonal behavior checklist at the within-person level but diverged somewhat at the dispositional level. Across the five samples, the VIAS generally performed as hypothesized at both the within- and between-person levels.
Women Literacy and Health Outcomes Inequality in Nepal
Authors: Shahi Min Bahadur
Published: July 2022

This article assesses the women literacy and health outcome inequality in Nepal. The study attempted to assess the nexus between women literacy and some key health outcomes based on provincial level data of Nepal. Basically the study follows the descriptive analysis with explanatory design under quantitative research based on the secondary data from ministry of health and population of Nepal (2017). Statistical analysis of provincial wise key health outcome data was done using chi-squire test of the goodness of fit to ensure evidence of inequality of the health outcome across the provinces of Nepal. Likewise, to find the causal relationship between women literacy rate (WLR) and institutional delivery rate (ID), contraceptive prevalence among married women (CPMW), child immunization rate (CIR), ANC (Antenatal Care) service receive by women (ANCRW), teenage pregnancy rate (TPR), total fertility rate (TFR) in seven provinces was observed using correlation and regression analysis tool. The result of chi-square test shows that there could be observed inequality in WLR and ID. Likewise, correlation analysis shows that there is positive correlation between WLR and ID, WLR and CPMW, and WLR and ANCRW but there is negative relation between WLR and CIR, WLR and TPR, WLR and TFR. The regression analysis shows that there is significant relationship among the variables WLR and ID, ANCRW, TPR, TFR. Therefore, it can be concluded that it is essential to increase women literacy to bring improvement in aforementioned key health outcomes. The implication of the study will help to make effective public health policy and strategy to reduce the equity gaps in health outcomes in Nepal.
भाषामा अवलम्बन, स्वीकरण र अपक्षयको स्थिति {The state of adherence, acceptance and degradation in language}
Authors: खतिवडा Khatiwada लयप्रसाद layaprasad
Published: July 2022

यस अनुसन्धानमूलक लेखमा सामाजिक भाषाविज्ञान र भाषामा अवलम्बन, स्वीकरण र अपक्षयको स्थितिका बारेमा अध्ययनमा गरिएको छ । मानिस सामाजिक प्राणी भएकाले उसले समाजमै भाषिक सिपहरू सुन्ने, बोल्ने, पढ्ने र लेख्नेगर्दछ । समाज भन्दा अलग रहेर व्यक्तिले भाषाको आदनप्रदान गर्न सक्दैन । भाषा सामाजिक वस्तु भएकाले यसको प्रत्यक्ष सम्बन्ध प्रत्येक भाषाभाषी र समाजसँग रहेको हुन्छ । भाषाको उत्पत्ति प्रयोग र विकास समाजमा नै हुन्छ । यदि भाषाको प्रयोग समाजले गरेन भने त्यस भाषालाई जीवित मानिदैन । जीवित भाषा हुनलाई समाजले प्रयोग गर्नै पर्दछ । व्यक्तिले बोल्ने आदरार्थी शब्दको प्रयोगबाट उसको सामाजिक स्तर थाहा पाउन सकिन्छ । बच्चा जन्मेपछि उसले समाजबाटै भाषासिक्ने, समाजमै व्यवहार गर्ने र समाजमै प्रयोग गर्ने भएकाले भाषामा सामाजिक विशेषता भेटिन्छ । यस अध्ययनमा सुविधाजनक नमुना छनोट विधिबाट प्राप्त भएका सूचनाका आधारमा व्याख्या विश्लेषण गरिएको छ । भाषामा अवलम्बन, स्वीकरण र अपक्षयको स्थितिलाई यस अध्ययनमा दस्तावेजको अध्ययनबाट सामग्री सङ्कलन गरी विश्लेषण गरिएको छ । सामाजिक भाषाविज्ञानको पहिचान, प्रकृति, प्रभाव र भाषाको सामाजिक भेदको पहिचानका आधारहरू तथा भाषामा अवलम्बन, स्वीकरण र अपक्षयको स्थिति के कस्तो छ ? भन्ने प्रश्नमा केन्द्रित रहेर त्यसको व्याख्या विश्लेषण गरिएकोछ । यस लेखमा सामाजिक भाषाविज्ञानको पहिचान र भाषामा अवलम्बन, स्वीकरण र अपक्षयको स्थितिलाई मुख्य समस्या बनाएर अध्ययन गरिएको हुँदा सामाजिक भाषाविज्ञानका बारेमा अध्ययन अनुसन्धान गर्न चाहनेहरूका लागि यो लेखऔचित्यपूर्ण हुनेछ । सामाजिक भाषाविज्ञानको पहिचान गरी यसको प्रकृति, प्रभाव र भाषामा अवलम्बन, स्वीकरण र अपक्षयको स्थितिका बारेमा निश्चित ढाँचा तयार गरिएको छ । सामाजिक तत्वहरू धर्म, वर्ग, जात, जाति, संस्कृति, रीतिरिवाज, लिङ्ग उमेर, शिक्षा, पेसा, आदर, पद प्रतिष्ठा आदि कारणले सामाजिक भाषाविज्ञानलाई निर्धारण गर्दछ भन्ने यस अध्ययनको निष्कर्ष रहेको छ ।
A Study of Maoist affected Jangle Mahal
Authors: Mandal Gurudas
Published: July 2022

Jangle Mahal is a barren and rugged land surrounded by hills and forests, sharing border Orissa and Jharkhand in the south- West of West Bengal. After a long period of Naxal Movement, Arms movement started again in West Bengal. In spite of century’s poverty and deprivation of the people in this region, no massive people’s movement has ever developed here since the independence. Even the land movements organized by communists during this period in other parts of the state did not significantly spread to this area. The Naxalist, first MMC group, and the peoples war group and finally after their unity, the CPI (Maoist) party try to organized the people since the 1980,s. the Maoists, no doubt are dedicated and self-sacrificing, working for the uplift and liberation of downtrodden people, though many have serious and reasonable differences with their methods. The Maoists gained the sympathy and support of the people of the jangle on the basis of the burning problems in the area. The simple indigenous people of jangle area had been alienated from the government due to government deprivation, The dominance of the ruling party, corruption in local government and the complexity of government machinery. After 2011 assembly election in west Bengal Trinamul congress (TMC) came into power led by Mamata Banerjee. The mamata’s government has initiated lots of efforts and welfare scheme to jangle mahal for peace and development. Although Mamata’s development agenda has undergone many changes in jangle mahal. But some important local issues still remain.
Mental health status of students enrolled in professional courses during Covid Pandemic in India
Authors: Jamali Ambreen , Pathak Ashish
Published: July 2022

Mental health has been always hidden behind a curtain of stigma and discrimination for too long. In the last few years, the world has become more aware of enormous burdens and the potential for mental health gains. In this research article, researchers aim to study the mental health and its coping mechanism of students who were enrolled in professional courses which require practical field exposure, during Covid Pandemic in India. During Covid lockdown beside of other things getting effected, students were too who got badly affected. Researchers took the opportunity to reach out to students to check their mental health in Pandemic era as together we can strengthen our community safety net to fight against mental disorder. Those students who were enrolled in professional courses and were about to be ready with their career opportunities were more likely to be affected by mental disorders more likely in the by neurosis. Researchers have taken Bachelors of Education and Masters of Social work students as prime respondents to assess the mental imbalance among them because of covid and stress. Researchers in this research found that since B.Ed and MSW are professional course which involves compulsory practical part including class room teaching and field visits so candidates found themselves in stress because of their career and future planning. Researcher has tried to analyze the mental health of students and ways to cope up with its imbalances. Through this study knowledge and awareness of students related to mental health will examined. Both primary and secondary data was analyzed to meet research objectives.
Intravitreal Ranibizumab in Pregnant Patient with Myopic Choroidal Neovascular Membrane. A Case Report
Authors: Penčák Martin , Veith Miroslav
Published: July 2022

Aim: To present the case of a patient with myopic choroidal neovascular membrane (mCNV) in the 3rd trimester of pregnancy, who was treated with intravitreal ranibizumab.

Case Report: The 34-year-old patient was referred to the Department of Ophthalmology of the University Hospital Kralovske Vinohrady in January 2020 for mCNV on her right eye (RE). The patient was in the 34th week of pregnancy. Initial best corrected visual acuity (BCVA) was 68 ETDRS letters. Spherical equivalent of the RE was -11.5 dioptres, axial length of the RE was 27.7 mm. Pigmented CNV with small haemorrhage was present on the retina of the RE. Optical coherence tomography (OCT) of the RE showed a hyperreflective mass above the retinal pigment epithelium, central retinal thickness (CRT) was 310 µm. OCT angiography confirmed the presence of a classic CNV in the macula of the RE. Two weeks later, the hyperreflective lesion and oedema in the macula of the RE increased, the CRT was 329 µm, BCVA remained stable. After discussion with the patient and the treating gynaecologist, intravitreal ranibizumab was administered in the RE in the 36th week of pregnancy. On check-up 3 weeks later, we observed the decrease of macular oedema to 276 µm and the improvement of BCVA to 78 ETDRS letters. The patient delivered a healthy baby girl in the 39th week of pregnancy via caesarean section, postnatal adaptation of the newborn was normal. During further visits, the BCVA improved to 83 ETDRS letters and the macular oedema disappeared completely. 8 months after the first ranibizumab injection, the CNV reactivated, BCVA decreased to 72 ETDRS letters, oedema was present in the macula and the CRT was 309 µm. Another ranibizumab was administered into the RE. The patient then discovered that she was pregnant; according to calculations, she was in the 3rd week of pregnancy at the time of the second ranibizumab injection. After the second injection, BCVA improved to 79 ETDRS letters, macular oedema on the OCT disappeared and CRT decreased to 264 µm. The pregnancy was terminated per patient’s request.

Conclusion: Intravitreal administration of ranibizumab in the 3rd trimester of pregnancy led to the improvement of BCVA and decrease of macular oedema in the patient with mCNV. The injection had no adverse effect on the pregnancy or the postnatal adaptation of the newborn. However, it is always necessary to consider the risk/benefit ratio when administering intravitreal antiVEGF drugs in pregnant patients. Thorough discussion with the patient is necessary.
Incidence of Pseudoexfoliation Syndrome and Glaucoma in a Set of more than 14 000 Eyes of Cataract-Operated Patients
Authors: Lachovská Silvie , Kristian Petr , Krowicka Justyna Helena
Published: July 2022

Purpose: Evaluation of the incidence of pseudoexfoliation (PEX) syndrome and glaucoma in cataract patients operated at our Clinic, with an analysis of possible complications.

Methodology: Retrospective evaluation of medical records of PEX syndrome patients who have undergone cataract surgery at the Gemini Eye Clinic Ostrava-Hrusov was undertaken. The study period was from November 2016 to April 2021. The evaluated parameters were the incidence of PEX syndrome, age and gender of patients, intraocular pressure (IOP) before the surgery, pre-existing therapy of previously diagnosed secondary glaucoma and the occurrence of perioperative complications.

Results: In the study period of 4.5 years, out of the total number of 14 167 operated eyes with cataracts there were 852 eyes of 689 patients with PEX syndrome diagnosed at our Clinic, i.e. 6.0 %. The mean age was 76.9 years, the median 77 years, range 54–100 years. The observed pathology was more common in women at a ratio of 1.84: 1 (552: 300). Elevation of IOP above 21 mmHg was recorded in 118 eyes, in 14 of them IOP reached values over 30 mmHg. Diagnosed and long-term treated secondary glaucoma was confirmed by 153 patients (204 eyes), out of which 22 eyes have undergone antiglaucoma laser (19 eyes) and / or surgery (5 eyes) in the anamnesis. Perioperatively, we recorded the following pathological findings accompanying the occurrence of PEX syndrome in 231 eyes. Most often it was poor artificial mydriasis (189 eyes), then subluxation of the lens (31 eyes) or zonular fragility (17 eyes). To reduce the risk of perioperative and postoperative complications, implantation of a capsular tension ring was indicated in 20 eyes. Complications during the procedure occurred in 11 eyes, of which 8 eyes were diagnosed with advanced cataract.

Conclusion: PEX syndrome and glaucoma are relatively common diseases that can complicate the lives of patients and eye surgeons. The incidence of PEX syndrome in our cataract patients was 6 %. Proper diagnosis of this disease is important not only for the possible occurrence of numerous complications during and after cataract surgery, but also for the possible presence of secondary glaucoma. It also serves to detect possible involvement of the contralateral eye. In addition, due to the involvement of practically all tissues in the body, the patient is endangered by numerous, especially vascular comorbidities. For these reasons, we find it appropriate that these patients are observed by other healthcare specialists. In our experience, early indication of cataract surgery is important to achieve a lower degree of zonular fragility and a softer lens core. In addition, lower levels of proinflammatory pseudoexfoliation material occur in the anterior segment of the eye in the early stages, which may have a beneficial effect on the postoperative healing
Amputação de dígito em um canino com carcinoma de células escamosas
Authors: Trindade Cargnelutti Hany
Published: July 2022

Squamous cell carcinoma (SCC) is a malignant tumor of keratinocytes, with low metastatic capacity, being considered the most common cutaneous neoplasm in white-coated dogs. The objective of the present work is to report the general aspects of SCC, diagnosis and treatment, based on a case report of a canine that underwent a digit amputation, as a result of an SCC.
Pendampingan dan Pengembangan Sistem Pengolahan Sampah serta Perancangan Produk Pupuk Cair Bernilai Market sebagai Produk Inovasi di Kelurahan Perwira Kota Bekasi Jawa Barat
Authors: Muhendra Rifki , Jatmiko Adhitya , Reviyanti Yuliana
Published: July 2022

Pengelolaan sampah dengan metode Reuse, Reduce dan Recycle atau dikenal dengan 3R telah diperkenalkan kemasyarakat oleh pemerintah, peneliti dan Lembaga lainnya lebih dari 10 tahun yang lalu. Metode ini efektif mengurangi volume sampah dan juga dampah negative yang ditimbulkan oleh sampah. Di kelurahan Perwira Kota Bekasi telah menerapkan pengelolaan sampah dengan metode ini namun terbatas pada sampah an organic. Pada paper ini dilaporkan program pengembangan system pengelolaan sampah organic menjadi sebuah produk inovasi berbasis masyarakat. Kegiatan ini terdiri dari studi kuantitatif produksi sampah, workshop pengelolaan sampah menjadi produk inovasi dan bernilai market. Hasil evaluasi kegiatan ini menujukkan adanya peningkatan kesadaran masyarakat terhadap pengelolaan sampah organic, peningkaatan wawasan akan system pengembangan produk inovasi dan strategi pemasaran digital. Lebih dari 70% masyarakat merasa bahwa kegiatan ini bermanfaat dan butuh kelanjutan.
Leadership for sustainability
Authors: Mathai Wanjira , del Socorro Aguilar Cucurachi Ma.
Published: July 2022

Fasten our green belts toward a resilient and sustainable future (p.4)
Wanjira Mathai

A more resilient future requires urgent actions to establish harmony between human development and nature, especially after the COVID-19 pandemic. Climate change adaptation requires investing in green belts as nature-based solutions, where innovative grassroots action, local and indigenous knowledge, and gender equality are key. Mathai discusses the question, what does it mean to tighten our green belts? Food systems, the protection of the “earth’s lungs,” the reduction of waste, and the restoration of landscapes are mainly addressed. The Green Belt Movement, led by women in Africa, showed how grassroots action scales up and impacts through long-term sustainable solutions. Restoration movements and initiatives worldwide represent a once-in-a-lifetime opportunity to restore landscapes for productivity, fight carbon emissions, and recover the ecosystem services to sustain human lives.

Percepciones locales para la restauración ecológica (p.12)
Ma. del Socorro Aguilar Cucurachi

A partir de las experiencias sobre el Movimiento Cinturones Verdes, presentadas por Wanjira Mathai en el marco de las Kapuscinski Development Lectures (en febrero 2021), destaco la importancia de la di-mensión social en los procesos de restauración y delineo cuatro formas posibles en las que las percepciones locales se vinculan con la restaura-ción ecológica: (1) las percepciones como impulso para la restauración; (2) la restauración ecológica como objeto de percepción; (3) las percepciones sobre la participación local en la restauración ecológica; y (4) la importancia de las sinergias epistémicas, multiactorales y multidimensio nales. La restauración ecológica implica una base científi ca, que considera entre sus principios la dimensión social, con benefi cios signifi cativos para el bienestar humano.
Genetic Divergence of Cultivated Rice Varieties in North Vietnam for Grain Quality Traits Using D2 Cluster Analysis
Authors: Thang Nguyen Ba
Published: July 2022

The study was carried out with twenty-four genotypes of rice during the Spring season, 2020 in Hanoi, Vietnam in order to exploit the attributes and divergence of quality properties from existing rice cultivars in North Vietnam. The rice genotypes were characterized based on ten quality parameters of milling, physical appearance and physiochemical characters using Mahalanobis D2 statistic. D2 analysis allocated the 24 genotypes into eight clusters, of which cluster I was the largest with 12 genotypes. The clustering showed the random distribution of genotypes into different clusters indicating that the origin and release duration were not related to the genetic diversity of grain quality. Among different traits, amylose content, length/width ratio and gel consistency were identified as topmost contributors in total divergence. Cluster I possessed a maximum intra-cluster value of 296.34 and the maximum inter-cluster distance was recorded between cluster IV and VI (2247.39) succeeded by cluster I and VI (2245.94) designing the members presented in these clusters can be exploited as potential donors in a breeding program to result good physicochemical quality traits in rice.
Fairness and Transparency in Payment for Forest Ecosystem Services Programs in Vietnam: A Community Based Evaluation
Authors: Son Cao Truong , Giang Nguyen Thi Huong , Nui Nguyen Hai , Lam Nguyen Thanh , Vien Tran Duc
Published: July 2022

Payment for forest environmental services (PFES) has been widely implemented in Vietnam for enhancing the reforestation and conservation of natural resources. However, fairness and transparency in the implementation of PFES programs have not been given due attention. In order to gather the community's opinions about the fairness and transparency of PFES's implementation, two case studies of direct and indirect payment programs in Bac Kan Province were selected to investigate. In this study, a five-point scale to rank the levels of "importance" and "implementation" of eight criteria of fairness and five criteria of transparency were used. There were 167 people who participated in the evaluation process through a questionnaire. The results pointed out that the community highly evaluated fairness and transparency in terms of "importance". Nevertheless, the "implementation" of these criteria had lower evaluation points. In comparing the evaluation results between the service providers and buyers, there were no statistically significant differences in terms of the "important" criteria. However, the difference between providers’ and buyers' evaluations regarding "implementation" were significant, with the mean values of the providers' being relatively higher than the buyers'. In addition, the analyses also found that participants in the direct program evaluated fairness and transparency higher than those in the indirect program. Finally, we state that policymakers and other stakeholders should include fairness and transparency criteria in designing the evaluation framework of PFES programs in Vietnam in order to promote more participation of people and improve the sustainability of PFES programs.
Classification of Cancer Response to Antiglycolytic Agents: An Approach to Understanding and Predicting Cancer
Authors: El Hadi Christopher
Published: July 2022

BACKGROUND: Cancer cells have exquisite metabolic activity in the glycolysis pathway compared to normal cells, which has been shown to provide them with sufficient fuel and molecular building blocks to maintain their proliferation. Inhibition of glycolytic pathways could therefore be an approach to target cancer. In this study, we sought to find the general categories of cancer cell responses to antiglycolytic agents, which could help predict cancer cell responses to drugs.

METHODS: Gene expression profiles from 199 experiments were downloaded from the GEO database and transformed into gene fold-changes. The most important genes were selected using the ATC top-value method and the samples were partitioned using "Spherical k-means" clustering, both methods being deemed superior by the authors of the _cola_ package. The one-sample chi-square test was used to investigate the predominance of samples in the clusters, followed by the Clopper-Pearson exact test to estimate this proportion of predominance. Signature genes were identified using the F-test for differential analysis; these were grouped using k-means clustering, and each group was functionally enriched with Gene Ontology and Reactome terms to extract biological significance.

RESULTS: Three responses were found. The first showed negative regulation of the mitotic cell cycle and associated intracellular activities and their regulation, as well as negative regulation of the cellular response to stress and DNA damage and antigen processing and presentation via MHC class I. The second response showed positive regulation and the third showed no effect on the above processes. In addition, the tissue samples were not distributed in a way that favored certain classes, an observation that demonstrates that the classification is sensitive to treatment.

CONCLUSIONS: We believe that cancer cells function through "molecular states" that are detectable by artificial intelligence and could potentially replace conventional cancer classifications. By studying the response of the cancer state to a given treatment, we can extrapolate this response to all cell lines that are already in that molecular category.
Incorporação de resíduos de pneu na produção de bloco maciço de concreto como alternativa de pavimentação urbana
Authors: Silva Maria das Graças Bezerra da , Ramos José Kleber da Costa , Laursen Anderson
Published: July 2022

O aumento da quantidade de resíduos sólidos gerados pela sociedade é uma das preocupações atuais, principalmente no que tange às questões ambientais. O pneu é um desses resíduos, que quando não descartado de forma correta, traz impactos danosos ao meio ambiente. Nesse contexto, verifica-se que pesquisas têm buscado a utilização de resíduos de pneus inservíveis na fabricação de compostos cimentícios usados na construção civil e na pavimentação. Dessa maneira, é possível que os blocos de concreto com adição de resíduos de borracha sejam utilizados em pavimentos urbanos? Visando agregar ao ramo de engenharia civil, o presente trabalho tem como objetivo principal realizar um estudo comparativo com relação ao uso de blocos intertravados de concreto com adição de resíduos de pneu. Para tanto, foram utilizadas substituições parciais de agregado miúdo por resíduo de pneu em proporções de 5%, 8% e 10% em massa. Ensaios de resistência à compressão aos 7 e 28 dias, a avaliação da absorção de água e a caracterização granulométrica dos agregados e do resíduo foram realizados. Encontrou-se que aos 28 dias todos os traços apresentaram resistência à compressão superior a 20 MPa havendo uma tendência de redução dessa propriedade diretamente influenciada pelo aumento da proporção de resíduo de pneu. O traço base uma média de 24,07 MPa enquanto o traço com 10% (T-10) 22,37 MPa. A absorção por imersão apresentou resultados de aproximadamente 4% para todas as condições. Dessa forma conclui-se que esse tipo de resíduo pode ser uma alternativa para a fabricação de blocos intertravados, sendo necessário o estudo de outros traços bem como a possibilidade de uso de aditivos. Porém, devido a sua resistência não ser atendida pela norma, o uso de blocos de concreto com incremento de resíduos de pneu não poderá ser feito em pavimentos.
Perancangan Board Game Sebagai Media Pembelajaran Tentang Pendakian Gunung
Authors: Aprelianto Giovanni , Setiawan Arie , Jason Prestilliano Jason
Published: July 2022

Climbing procedures in mountaineering is important and how to climbers to avoid climbing accidents. Although there are many web media or social media that teach about this, most hikers are still laymen and do not apply climbing procedures in their ascent especially among young people. Awareness regarding proper climbing procedures must be raised to young people so that they can apply climbing procedures properly and appropriately. To make young people interested in learning about climbing procedures, there must be interactive learning media related to mountain climbing procedures. The purpose of this study was to design a board game "Mountainance" as a medium of learning and to raise awareness of lay climbers among young people about mountaineering procedures. This research uses descriptive method, linear strategy and a combination approach. The result of this study is that young people become more aware of climbing procedures after playing the board game "Mountainance".
Keywords: learning media, mountaineering, board game.
Socio-cultural nature, essence and genesis of the antagonism of mental values of Ukraine and Russia
Authors: Sahaidak Mikhailo , Smyrnov Yevhen , Smyrnova Olha
Published: July 2022

The article, based on retrospective analysis and historical comparison, studies the genesis of antagonism between Ukraine and Russia in terms of the phenomenon of national identity, authenticity and distancing. Identifying the significant difference between the objective mental values, socio-cultural features of the Ukrainian and Russian peoples allowed to identify the main stages of historical, social and political and economic development that contributed to the separation of elements of Ukrainian statehood and independence. Elaboration and analysis of the existing interstate relations between Ukraine and Russia, through the prism of healthy skepticism, allowed to rethink and draw conclusions on forecasting the future development of relations against sanctions against interstate and global levels, as well as to determine Ukraine’s place on the geopolitical map of the modern world.
Protocolo de limpieza y desinfección de simuladores médicos
Authors: Arboleda Amórtegui Gleydiz
Published: July 2022

Las nuevas tecnologías en la simulación medica nos llevan a tener procesos de calidad en el cuidado de los equipos y simuladores médicos. Por lo tanto, es necesario centrar la atención en la verificación de los mismos para cumplir con los requerimientos de cada uno teniendo en cuenta las especificaciones planteadas en cada ficha técnica. El propósito de este texto es redactar un protocolo de limpieza y desinfección para los simuladores de la Facultad Ciencias de la Salud de la Fundación Universitaria del Área Andina. Se realizó una revisión exploratoria para conocer los procesos de limpieza y desinfección de los simuladores mediante literatura existente, utilizando estudios realizados sobre simulación médica, sus generalidades y cuidados, y que hayan sido publicados como artículos científicos originales en revistas durante el periodo 2014-2019. Se identificaron 8 estudios que usaron como indicador principal el cuidado preventivo de simuladores médicos.
Performance Limits of 433 MHz Quarter-wave Monopole Antennas due to Grounding Dimension and Conductivity
Authors: Li Jinfeng
Published: July 2022

Among antennas for Industrial, Scientific and Medical (ISM band) applications at 433 MHz, quarter-wave monopole is a reasonably good trade-off between size, gain, and cost. The electrical performance of the monopole is largely dependent on the quality of the ground plane (size and conductivity), which exhibits a practical limit on the achievable gain as most industrial user environments can provide only a finite ground plane of finite electrical conductivity. Establishing traceability in understanding the performance degradation due to such limits due to the grounding dimension and conductivity is becoming mandatory. To this end, this work leverages universal MATLAB in place of off-the-shelf software (HFSS or CST) for the quarter-wave monopole antenna simulation at 433 MHz parametrised with the ground plane’s dimension with respect to the wavelength (λ). Results indicate that by enlarging the ground plane’s size from 0.14 λ to 14 λ, the gain (directivity for PEC) from the 3D radiation pattern rises from 1.79 dBi, then starts levelling off at 6.7 dBi (5.78 λ), until saturating at 7.49 dBi (13 λ). The radiation efficiency and gain of various grounding conductivity scenarios (e.g., gold, aluminium, steel) are also quantified to inform antenna designers and engineers for commercial, industrial, defence and space applications.
Hands in the machine
Authors: Walton Saige
Published: July 2022

In this article, I examine how Maya Deren and Marie Menken’s mid-1940s filmmaking enacts a gestural aesthetic. Drawing on Vilém Flusser’s thinking on gesture (his discussion of “moving tools” and the thoughtfulness of hands), I draw attention to the importance of hands in Deren and Menken’s work. In Visual Variations on Noguchi (1945), Menken employs a handheld Bolex camera to explore the different material properties of art objects. Through her sweeping camerawork, film editing and sound, she transforms Noguchi’s art into new, cinematically stuttering, borderline abstract compositions. In At Land (1944), Deren’s unnamed protagonist (played by Deren herself) is filmed reaching, touching, clasping and grasping her way through a highly mutable world. In Deren’s re-working of the mythic quest narrative, hands function as a gestural, thoughtful means of adaptation. Hands also provide Deren with a manual means of manipulating “film form”, of manually piecing together different surfaces, shots and scenes. In Visual Variations on Noguchi and in At Land, both artist-filmmakers use their “moving tools” to transform human gesture. Through their foregrounding of the hands (onscreen and offscreen), Deren and Menken enact a desubjectified, gestural cinema.