bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Virtual Sensors for Bead Size Measurements in Wire-Arc Directed Energy Deposition
Authors: Fernández-Zabalza Aitor , Veiga Fernando , Suárez Alfredo , López José Ramón Alfaro
Published: February 2024

Having garnered significant attention in the scientific community over the past decade, wire-arc directed energy deposition (arc-DED) technology is at the heart of this investigation into additive manufacturing parameters. Singularly focused on Invar as the selected material, the primary objective revolves around devising a virtual sensor for the indirect size measurement of the bead. This innovative methodology involves the seamless integration of internal signals and sensors, enabling the derivation of crucial measurements sans the requirement for direct physical interaction or conventional measurement methodologies. The internal signals recorded, the comprising voltage, the current, the energy from the welding heat source generator, the wire feed speed from the feeding system, the traverse speed from the machine axes, and the temperature from a pyrometer located in the head were all captured through the control of the machine specially dedicated to the arc-DED process during a phase of optimizing and modeling the bead geometry. Finally, a feedforward neural network (FNN), also known as a multi-layer perceptron (MLP), is designed, with the internal signals serving as the input and the height and width of the bead constituting the output. Remarkably cost-effective, this solution circumvents the need for intricate measurements and significantly contributes to the proper layer-by-layer growth process. Furthermore, a neural network model is implemented with a test loss of 0.144 and a test accuracy of 1.0 in order to predict weld bead geometry based on process parameters, thus offering a promising approach for real-time monitoring and defect detection.
Regional Geochemical Characteristics of Lithium in the Mufushan Area, South China
Authors: Li Peiyu , Gong Qingjie , Chen Shaoyu , Li Peng , Li Jiankang , Wu Xuan , Li Xiaolei , Wang Xuefeng , Liu Ningqiang
Published: February 2024

With the explosive growth in demand for lithium (Li) resources, the Mufushan area has been a hotspot for Li deposit exploration in China in recent years. Geochemical maps and geochemical anomaly maps are basic maps in the geochemical exploration of mineral resources. A fixed-value method to contour a Li geochemical map is presented here, in which Li concentrations are divided into 19 levels on 18 fixed values, ranging from 5 μg/g (corresponding to the detection limit) to 1858 μg/g (corresponding to the cut-off grade of Li deposit in hard-rock type) and illustrated in six color tones corresponding to Li areas of low background, high background, low anomaly, high anomaly, mineralization in clay-type, and mineralization in hard-rock type. The geochemical map of Li in the Mufushan area using the new fixed-value method indicates that the study area belongs to the high background area, and the known Li deposits are located in the high anomaly areas. In addition, the geochemical anomaly map of the Mufushan area is drawn using the method of seven levels of classification, and indicates that the known Li deposits are all in the anomaly areas, with anomaly levels not lower than the second level. Furthermore, four other areas are recognized for Li resource potential based on the geochemical map and geochemical anomaly map in the Mufushan area.
Survey on Quality of Experience Evaluation for Cloud-Based Interactive Applications
Authors: Arellano-Uson Jesus , Magaña Eduardo , Morato Daniel , Izal Mikel
Published: February 2024

A cloud-based interactive application (CIA) is an application running in the cloud with stringent interactivity requirements, such as remote desktop and cloud gaming. These services have experienced a surge in usage, primarily due to the adoption of new remote work practices during the pandemic and the emergence of entertainment schemes similar to cloud gaming platforms. Evaluating the quality of experience (QoE) in these applications requires specific metrics, including interactivity time, responsiveness, and the assessment of video- and audio-quality degradation. Despite existing studies that evaluate QoE and compare features of general cloud applications, systematic research into QoE for CIAs is lacking. Previous surveys often narrow their focus, overlooking a comprehensive assessment. They touch on QoE in broader contexts but fall short in detailed metric analysis. Some emphasise areas like mobile cloud computing, omitting CIA-specific nuances. This paper offers a comprehensive survey of QoE measurement techniques in CIAs, providing a taxonomy of input metrics, strategies, and evaluation architectures. State-of-the-art proposals are assessed, enabling a comparative analysis of their strengths and weaknesses and identifying future research directions.
Feature of Review Papers in Nanotechnology and Applied Nanosciences
Authors: Lambin Philippe
Published: February 2024

Nanoparticles have been in use for centuries [...]
A Robust Distributed Algorithm for Solving the Economic Dispatch Problem with the Penetration of Renewables and Battery Systems
Authors: Kubicek Karel , Cech Martin , Strelec Martin
Published: February 2024

In the field of energy networks, for their effective functioning, it is necessary to distribute the required load between all online generating units in a proper way to cover the demand. The load schedule is obtained by solving the so-called Economic Dispatch Problem (EDP). The EDP can be solved in many ways, resulting in a power distribution plan between online generating units in the network so that the resulting price per unit of energy is minimal. This article focuses on designing a distributed gradient algorithm for solving EDP, supplemented by models of renewable sources, Battery Energy Storage System (BESS), variable fuel prices, and consideration of multiple uncertainties at once. Specifically, these are: time-variable transport delays, noisy gradient calculation, line losses, and drop-off packet representations. The algorithm can thus be denoted as robust, which can work even in unfavorable conditions commonly found in real applications. The capabilities of the presented algorithm will be demonstrated and evaluated on six examples.
OrientedDiffDet: Diffusion Model for Oriented Object Detection in Aerial Images
Authors: Wang Li , Jia Jiale , Dai Hualin
Published: February 2024

Object detection is a fundamental task of remote-sensing image processing. Most existing object detection detectors handle regression and classification tasks through learning from a fixed set of learnable anchors or queries. To simplify object candidates, we propose a denoising diffusion process for remote-sensing image object detection, which directly detects objects from a set of random boxes. During the training phase, the horizontal detection boxes are transformed into oriented detection boxes firstly. Then, the model learns to reverse this transformation process by diffusing from the ground truth-oriented box to a random distribution. During the inference phase, the model incrementally refines a set of randomly generated boxes to produce the final output result. Remarkable results have been achieved using our proposed method. For instance, on commonly used object detection datasets such as DOTA, our approach achieves a mean average precision (mAP) of 76.59%. Similarly, on the HRSC2016 dataset, our method achieves a 72.4% mAP.
Feasibility of Non-Remanufactured Waste Bottle Glass as Supplementary Cementitious Material
Authors: Matos Ana Mafalda , Sousa-Coutinho Joana
Published: February 2024

Theoretically, glass can be recycled entirely, but there are several requirements for remanufacturing. For the first time, this work studied industrial bottle waste glass (WG), which cannot be used to remanufacture new glass as a cement replacement for concrete applications. Wet and dry milling treatments were performed to reduce the particle size of WG and remove fibre and plastic contaminants. The different waste glasses treated were characterised by chemical, physical, and morphological analysis. Afterwards, mortar-level studies followed, using raw WG and wet-milled WG (AGWG) as a 10% Portland cement replacement. Mechanical and several durability indicators were assessed. WG and AGWG incorporation improved mortar performance against water capillary absorption, chloride ingress, and alkali–silica reaction. The unfavourable effect, namely, mechanical strength loss on glass-modified mortars, was mainly due to fibre contaminants observed by SEM on WG and AGWG samples. Even though wet milling reduced the amount and length of the fibre contaminants, it still did not guarantee adequate mechanical strength for the mortar. Thus, additional or alternative treatments, such as thermal treatments, must be explored.
Golden Swords of the Early Nomads of Eurasia: A New Classification and Chronology
Authors: Topal Denis
Published: February 2024

The “ceremonial” forms of swords and daggers—that is, bladed weapons decorated with precious metals—occupy a special place in the culture of the early nomads. For the Scythian period, we know at least 76 ceremonial objects from 61 sites, corresponding to 3.5% of the total sample. More than half of the finds come from the northern Black Sea region (mainly Ukraine). Ceremonial forms are represented in all morphological categories (from daggers to extra-long swords), but their distribution is slightly different. Most akinakai belong to the average and long swords. Most Scythian akinakai in Eurasia belong to the dagger and short sword groups. Although most Scythian swords and daggers fall into the Middle Scythian period, most ceremonial forms belong to the last phase of Classical Scythian culture. This period is a veritable “golden autumn” of Scythia with its huge royal burial mounds and abundance of gold, perfectly illustrating our argument that conspicuous consumption coincides with periods of political and social instability. After the peak of the proliferation of ceremonial akinakai in the third quarter of the 4th century BC, we observe a generation later the complete disappearance of Classical Scythian culture, along with its characteristic weapons, horse harnesses, and animal style.
Ross–Weddell Dipole Critical for Antarctic Sea Ice Predictability in MPI–ESM–HR
Authors: Zanchettin Davide , Modali Kameswarrao , Müller Wolfgang A. , Rubino Angelo
Published: February 2024

We use hindcasts from a state-of-the-art decadal climate prediction system initialized between 1979 and 2017 to explore the predictability of the Antarctic dipole—that is, the seesaw between sea ice cover in the Weddell and Ross Seas, and discuss its implications for Antarctic sea ice predictability. Our results indicate low forecast skills for the Antarctic dipole in the first hindcast year, with a strong relaxation of March values toward the climatology contrasting with an overestimation of anomalies in September, which we interpret as being linked to a predominance of local drift processes over initialized large-scale dynamics. Forecast skills for the Antarctic dipole and total Antarctic sea ice extent are uncorrelated. Limited predictability of the Antarctic dipole is also found under preconditioning around strong warm and strong cold events of the El Niño-Southern Oscillation. Initialization timing and model drift are reported as potential explanations for the poor predictive skills identified.
On Protected Quasi-Metrics
Authors: Romaguera Salvador
Published: February 2024

In this paper, we introduce and examine the notion of a protected quasi-metric. In particular, we give some of its properties and present several examples of distinguished topological spaces that admit a compatible protected quasi-metric, such as the Alexandroff spaces, the Sorgenfrey line, the Michael line, and the Khalimsky line, among others. Our motivation is due, in part, to the fact that a successful improvement of the classical Banach fixed-point theorem obtained by Suzuki does not admit a natural and full quasi-metric extension, as we have noted in a recent article. Thus, and with the help of this new structure, we obtained a fixed-point theorem in the framework of Smyth-complete quasi-metric spaces that generalizes Suzuki’s theorem. Combining right completeness with partial ordering properties, we also obtained a variant of Suzuki’s theorem, which was applied to discuss types of difference equations and recurrence equations.
Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin
Authors: Sidorov Veniamin Y. , Sidorova Tatiana N. , Samson Philip C. , Reiserer Ronald S. , Britt Clayton M. , Neely M. Diana , Ess Kevin C. , Wikswo John P.
Published: February 2024

The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric diseases for which animal models, immortal cell lines, and biopsy samples are unavailable. It also allows for a rapid assessment of phenotype–genotype relationships and tissue response to pharmacological manipulation. Mutations in the TSC1 and TSC2 genes lead to dysfunctional mTOR signaling and cause tuberous sclerosis complex (TSC), a genetic disorder that affects multiple organ systems, principally the brain, heart, skin, and kidneys. Here we differentiated healthy (CC3) and tuberous sclerosis (TSP8-15) human induced pluripotent stem cells (hiPSCs) into cardiomyocytes to create engineered cardiac tissue constructs (ECTCs). We investigated and compared their mechano-elastic properties and gene expression and assessed the effects of rapamycin, a potent inhibitor of the mechanistic target of rapamycin (mTOR). The TSP8-15 ECTCs had increased chronotropy compared to healthy ECTCs. Rapamycin induced positive inotropic and chronotropic effects (i.e., increased contractility and beating frequency, respectively) in the CC3 ECTCs but did not cause significant changes in the TSP8-15 ECTCs. A differential gene expression analysis revealed 926 up- and 439 down-regulated genes in the TSP8-15 ECTCs compared to their healthy counterparts. The application of rapamycin initiated the differential expression of 101 and 31 genes in the CC3 and TSP8-15 ECTCs, respectively. A gene ontology analysis showed that in the CC3 ECTCs, the positive inotropic and chronotropic effects of rapamycin correlated with positively regulated biological processes, which were primarily related to the metabolism of lipids and fatty and amino acids, and with negatively regulated processes, which were predominantly associated with cell proliferation and muscle and tissue development. In conclusion, this study describes for the first time an in vitro TSC cardiac tissue model, illustrates the response of normal and TSC ECTCs to rapamycin, and provides new insights into the mechanisms of TSC.
Advancing Ocular Imaging: A Hybrid Attention Mechanism-Based U-Net Model for Precise Segmentation of Sub-Retinal Layers in OCT Images
Authors: Karn Prakash Kumar , Abdulla Waleed H.
Published: February 2024

This paper presents a novel U-Net model incorporating a hybrid attention mechanism for automating the segmentation of sub-retinal layers in Optical Coherence Tomography (OCT) images. OCT is an ophthalmology tool that provides detailed insights into retinal structures. Manual segmentation of these layers is time-consuming and subjective, calling for automated solutions. Our proposed model combines edge and spatial attention mechanisms with the U-Net architecture to improve segmentation accuracy. By leveraging attention mechanisms, the U-Net focuses selectively on image features. Extensive evaluations using datasets demonstrate that our model outperforms existing approaches, making it a valuable tool for medical professionals. The study also highlights the model’s robustness through performance metrics such as an average Dice score of 94.99%, Adjusted Rand Index (ARI) of 97.00%, and Strength of Agreement (SOA) classifications like “Almost Perfect”, “Excellent”, and “Very Strong”. This advanced predictive model shows promise in expediting processes and enhancing the precision of ocular imaging in real-world applications.
The Impact of Cytomegalovirus Infection on Natural Killer and CD8+ T Cell Phenotype in Multiple Sclerosis
Authors: Perri Valentina , Zingaropoli Maria Antonella , Pasculli Patrizia , Ciccone Federica , Tartaglia Matteo , Baione Viola , Malimpensa Leonardo , Ferrazzano Gina , Mastroianni Claudio Maria , Conte Antonella , Ciardi Maria Rosa
Published: February 2024

Multiple sclerosis (MS) is a debilitating neurological disease that has been classified as an immune-mediated attack on myelin, the protective sheath of nerves. Some aspects of its pathogenesis are still unclear; nevertheless, it is generally established that viral infections influence the course of the disease. Cytomegalovirus (CMV) is a major pathogen involved in alterations of the immune system, including the expansion of highly differentiated cytotoxic CD8+ T cells and the accumulation of adaptive natural killer (NK) cells expressing high levels of the NKG2C receptor. In this study, we evaluated the impact of latent CMV infection on MS patients through the characterization of peripheral NK cells, CD8+ T cells, and NKT-like cells using flow cytometry. We evaluated the associations between immune cell profiles and clinical features such as MS duration and MS progression, evaluated using the Expanded Disability Status Scale (EDSS). We showed that NK cells, CD8+ T cells, and NKT-like cells had an altered phenotype in CMV-infected MS patients and displayed high levels of the NKG2C receptor. Moreover, in MS patients, increased NKG2C expression levels were found to be associated with higher EDSS scores. Overall, these results support the hypothesis that CMV infection imprints the immune system by modifying the phenotype and receptor repertoire of NK and CD8+ T cells, suggesting a detrimental role of CMV on MS progression.
The Association between Delayed Gut Microbiota Maturity in Pre-Term Infants and the Feeding Intolerance—A Pilot Study
Authors: Hsu Ya-Chi , Lin Ming-Chih , Ardanareswari Katharina , Lowisia Webiana , Lin Yi-Hsuan , Chen Yi-Jhen , Hsu Cheng-Kuang , Chung Yun-Chin
Published: February 2024

This study compared gut (fecal) microbiota profiles between pre-term and full-term infants, assuming that pre-term infants without feeding intolerance would have gut microbiota similar to those of full-term infants. A total of 13 pre-term infants (gestational age < 37 weeks, birthweight ≤ 2500 g) and 10 full-term infants were included. The pre-term infants were assigned to the feeding tolerance (FT) group (n = 7) if their daily intake exceeded 100 mL/kg/day at two weeks after birth, or the feeding intolerance (FI) group (n = 6). Microbial DNA from weekly fecal samples was analyzed. The microbiota profiles of the pre-term infants and full-term infants were significantly different (p = 0.0001), as well as the FT and FI groups (p = 0.0009). The full-term group had more diversity, with higher concentrations of facultative anaerobes such as Bifidobacteriaceae and Lactobacteriaceae. The FT group’s gut microbiota matured over four weeks, with higher levels of digestion-related bacteria, while the FI group had more pathogens. In the FI group, a significant difference was observed between the first and second weeks, with no significant differences noted between the first week and the third or fourth weeks. The delay in the development of the pre-term infants’ gut microbiota may be associated with the FI.
Rift Valley Fever Virus: An Overview of the Current Status of Diagnostics
Authors: Lapa Daniele , Pauciullo Silvia , Ricci Ida , Garbuglia Anna Rosa , Maggi Fabrizio , Scicluna Maria Teresa , Tofani Silvia
Published: February 2024

Rift Valley fever is a vector-borne zoonotic disease caused by the Rift Valley fever virus (Phlebovirus genus) listed among the eight pathogens included in the Bluepoint list by the WHO. The transmission is mainly vehicled by Aedes and Culex mosquito species. Symptoms of the disease are varied and non-specific, making clinical diagnosis often challenging, especially in the early stages. Due to the difficulty in distinguishing Rift Valley fever from other viral hemorrhagic fevers, as well as many other diseases that cause fever, an early diagnosis of the infection is important to limit its spread and to provide appropriate care to patients. To date, there is no validated point-of-care diagnostic tool. The virus can only be detected in the blood for a brief period, suggesting that molecular methods alone are not sufficient for case determination. For this, it is preferable to combine both molecular and serological tests. The wide distribution of competent vectors in non-endemic areas, together with global climate change, elicit the spread of RVFV to continents other than Africa, making surveillance activities vital to prevent or to limit the impact of human outbreaks and for a rapid identification of positive cases, making diagnosis a key factor for this achievement.
Functionalized Gold Nanoparticles for Facile Pattern-Controlled Surface Coatings
Authors: Wang Jue , Liang Junfeng
Published: February 2024

Gold nanoparticles (AuNPs) have been widely investigated as surface modifiers; nevertheless, most methods still require the pretreatment of surfaces and several steps to control coating efficiency and patterns for improved functionality. We developed functionalized AuNPs through borate-protected dopamine (B-AuNPs). The simple activation of B-AuNPs with a strong acid to remove the protected borate groups produces adhesive dopamine AuNPs (D-AuNPs). D-AuNP-coated surfaces with varied but controlled features and properties such as coating density and surface pattern were achieved using D-AuNPs with a precisely controlled dopamine density and coating conditions. Such adhesive and easily manipulated AuNPs provide a facile and time-saving technology to achieve sophisticated surface coatings using AuNPs.
Treatments for Cannabis Use Disorder across the Lifespan: A Systematic Review
Authors: Ghafouri Mohammad , Correa da Costa Sabrina , Zare Dehnavi Ali , Gold Mark S. , Rummans Teresa A.
Published: February 2024

Cannabis use disorder (CUD) is a growing public health concern, with rising prevalence and significant impact on individuals across age groups. This systematic review examines 24 studies investigating pharmacological and non-pharmacological interventions for CUD among adolescents (up to 17), young adults (18–24), and older adults (25–65). Database searches were conducted for randomized controlled trials of CUD interventions reporting outcomes such as cannabis use, abstinence, withdrawal symptoms, and treatment retention. For adolescents, interventions such as contingent rewards and family engagement have shown promise, while young adults benefit from technology-based platforms and peer support. In older adults, pharmacological adjuncts combined with counseling have shown promise in enhancing treatment outcomes. However, optimal treatment combinations remain uncertain, highlighting the need for further research. Addressing CUD requires tailored interventions that acknowledge developmental stages and challenges across the lifespan. Although promising interventions exist, further comparative effectiveness research is needed to delineate the most efficacious approaches.
Influence of Sevoflurane on the Neurological Pupil Index in Surgical and Critically Ill Patients: A Pilot Study
Authors: Dallemagne Alice , Anderloni Marco , Havaux Mathias , Duranteau Olivier , Taccone Fabio Silvio
Published: February 2024

Background: The aim of this study was to compare the effects of sevoflurane on the neurologic pupil index (NPi), obtained by means of automated pupillometry, between intensive care unit (ICU) and surgical patients. Methods: This was a prospective single-center study conducted between December 2021 and February 2023. The eligible population comprised all patients undergoing general anesthesia (GA) for visceral surgery (VS) or neurosurgery (NS) and ICU patients receiving inhaled sevoflurane, according to the decision of the treating physician. The NPi measurements were conducted before GA (T0), after induction (T1), after the initiation of sevoflurane (T2), and at the point of discontinuation of sevoflurane (T3). Results: A total of 41 VS, 16 NS, and 22 ICU patients (out of which, 12 had a brain injury) were included. In the VS and NS groups, there was a significant decrease in the NPi over time, which remained within normal ranges. The NPi values decreased over time in the ICU group after sevoflurane administration. At T2, the NPi values were lower in the ICU group compared to the other groups. Lower NPi values were observed in the ICU patients with a brain injury compared to other patients. Conclusions: The administration of inhaled sevoflurane was associated with a significant reduction in the NPi values of the ICU patients with a concomitant brain injury.
Relationships between Sleep Quality, Introspective Accuracy, and Confidence Differ among People with Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder with Psychotic Features
Authors: Springfield Cassi R. , Pinkham Amy E. , Harvey Philip D. , Moore Raeanne C. , Ackerman Robert A. , Depp Colin A. , Bonfils Kelsey A.
Published: February 2024

People with schizophrenia-spectrum and bipolar disorders have difficulty accurately estimating their abilities and skills (impaired introspective accuracy [IA]) and tend to over- or underestimate their performance. This discrepancy between self-reported and objective task performance has been identified as a significant predictor of functional impairment. Yet, the factors driving this discrepancy are currently unclear. To date, the relationships between sleep quality and IA have not been examined. The current study aimed to explore the relationships between sleep quality and IA in participants diagnosed with schizophrenia (SCZ; n = 36), schizoaffective disorder (SCZ-A; n = 55), and bipolar disorder with psychotic features (BP; n = 87). Participants completed tasks of emotion recognition, estimated their performance on the tasks (used to calculate IA), and provided confidence ratings for their accuracy judgments. Participants also self-reported their sleep quality. These results suggest significantly greater discrepancies between self-reported and actual task scores for those with SCZ and SCZ-A compared to participants with BP. For those with SCZ, lower confidence on the tasks and underestimation of abilities were associated with lower sleep quality, while for those with SCZ-A, lower sleep quality was associated with higher confidence and overestimation of performance. Results suggest differential relationships between diagnostic groups. Future research is needed to further explore the factors driving these differing relationships, particularly the contrasting relationships between SCZ and SCZ-A.
Natural Gas Consumption Monitoring Based on k-NN Algorithm and Consumption Prediction Framework Based on Backpropagation Neural Network
Authors: Hou Yaolong , Wang Xueting , Chang Han , Dong Yanan , Zhang Di , Wei Chenlin , Lee Inhee , Yang Yijun , Liu Yuanzhao , Zhang Jipeng
Published: February 2024

With increasing consumption of primary energy and deterioration of the global environment, clean energy sources with large reserves, such as natural gas, have gradually gained a higher proportion of the global energy consumption structure. Monitoring and predicting consumption data play a crucial role in reducing energy waste and improving energy supply efficiency. However, owing to factors such as high monitoring device costs, safety risks associated with device installation, and low efficiency of manual meter reading, monitoring natural gas consumption data at the household level is challenging. Moreover, there is a lack of methods for predicting natural gas consumption at the household level in residential areas, which hinders the provision of accurate services to households and gas companies. Therefore, this study proposes a gas consumption monitoring method based on the K-nearest neighbours (KNN) algorithm. Using households in a residential area in Xi’an as research subjects, the feasibility of this monitoring method was validated, achieving a model recognition accuracy of 100%, indicating the applicability of the KNN algorithm for monitoring natural gas consumption data. In addition, this study proposes a framework for a natural gas consumption prediction system based on a backpropagation (BP) neural network.
A Review of Life Cycle Construction Process and Cutting-Edge Technology in Prefabricated MEP Installation Engineering
Authors: Yan Gangwen , Yang Yinghui , Zhang Huizhong , Li Zhenwei , Chen Song , Zhao Xuefeng , Sun Zhe , Fan Xiongtao , Zhang Meng , Huang Lingli , Liu Liang
Published: February 2024

Prefabricated installation, a pivotal study in the realm of contemporary construction practices, delves into the utilization of prefabrication within mechanical, electrical, and plumbing (MEP) systems. Despite its ascending prominence, the domain grapples with ambiguities in application pathways, uncertain developmental trajectories, and the absence of a holistic technical paradigm. This research endeavors to bridge these gaps by conducting a thorough and multidimensional investigation into the current landscape of prefabricated MEP installation initiatives. This study meticulously dissects the paradigm from five critical vantage points: historical evolution, standards and regulations, life cycle analysis, technological applications, and corporate implementation strategies. At present, there is still a lack of standards and specifications specifically for the field of assembled MEP installation. The analysis reveals a trend towards intelligent and sustainable installation practices in prefabricated MEP projects. The research predominantly focuses on the design, production, and installation stages. Notably, building information modeling (BIM) emerges as the most prominent technology, followed by the Internet of Things (IoT) and 3D laser scanning, with extended reality (XR) technologies gaining traction. Large, state-owned construction firms are spearheading innovative applications in this realm. In summary, this paper provides an overview and outlook for the development direction and the application of cutting-edge technologies in prefabricated MEP installation projects, with the aim of supporting the industry’s advancement.
Full Size Two-Layer Steel Frame–Exterior Wall Panel Shaking-Table Test
Authors: Yang Beibei , Li Zhenbao , Liu Ping , Ma Hua , Yang Jiulong , Kang Zhicheng
Published: February 2024

A cantilever block wall-panel attachment strip (CBW) flexible connection node was designed to connect precast concrete (PC) exterior wall panels to steel frames. To investigate the performance of the CBW flexible connection node and PC exterior wall panels during earthquakes, a partial two-storey steel frame was extracted from an actual engineering structure, and a full-scale steel frame–exterior wall panel shaking-table model was designed. Two sets of shaking-table tests were conducted under seismic intensity 7, 8, and 9 (Chinese Seismic Intensity Scale) earthquakes. The acceleration and displacement responses of the composite wall panel, open window panel, and integral wall panel along the in-plane and out-of-plane motions were analysed. The acceleration amplification factors of the PC exterior wall panels ranged from 0.753 to 1.400 (in-plane) and from 0.998 to 2.199 (out-of-plane). The CBW flexible connection node had a deformation capacity that could coordinate the deformation of the exterior wall panel and prevent severe damage. The surfaces of the PC exterior wall panels remained intact during a very strong seismic intensity 9 earthquake.
Evaluation of Design Parameters for Daylighting Performance in Secondary School Classrooms Based on Field Measurements and Physical Simulations: A Case Study of Secondary School Classrooms in Guangzhou
Authors: Luo Jianhe , Yan Gaoliang , Zhao Lihua , Zhong Xue , Su Xinyu
Published: February 2024

The quality of natural lighting within secondary school classrooms can significantly affect the physical and mental well-being of both teachers and students. While numerous studies have explored various aspects of daylighting performance and its related factors, there is no universal standard for predicting and optimizing daylighting performance from a design perspective. In this study, a method was developed that combines measurements and simulations to enhance the design parameters associated with daylighting performance. This approach facilitates the determination of precise ranges for multiple design parameters and allows for the efficient attainment of optimal daylighting performance. Daylight glare probability (DGP), point-in-time illuminance (PIT), daylight factor (DF), and lighting energy consumption were simulated based on existing control parameters of operational classrooms. The simulation results were then validated using field measurements. Genetic algorithms (GAs) were employed to optimize the control parameters, yielding a set of optimal solutions for improving daylight performance. The differences between daylighting performance indicators corresponding to the optimal solution set and those of the basic model were compared to test the performance of the optimized parameters. The proposed method is a robust process for optimizing daylight design parameters based on GAs, which not only enhances daylighting performance but also offers scientifically grounded guidelines for the design phase. It is a valuable framework for creating healthier and more productive educational environments within secondary school classrooms.
Tumor Predisposing Post-Zygotic Chromosomal Alterations in Bladder Cancer—Insights from Histologically Normal Urothelium
Authors: Stańkowska Wiktoria , Sarkisyan Daniil , Bruhn-Olszewska Bożena , Duzowska Katarzyna , Bieńkowski Michał , Jąkalski Marcin , Wójcik-Zalewska Magdalena , Davies Hanna , Drężek-Chyła Kinga , Pęksa Rafał , Harazin-Lechowska Agnieszka , Ambicka Aleksandra , Przewoźnik Marcin , Adamczyk Agnieszka , Sasim Karol , Makarewicz Wojciech , Matuszewski Marcin , Biernat Wojciech , Järhult Josef D. , Lipcsey Miklós , Hultström Michael , Frithiof Robert , Jaszczyński Janusz , Ryś Janusz , Genovese Giulio , Piotrowski Arkadiusz , Filipowicz Natalia , Dumanski Jan P.
Published: February 2024

Bladder urothelial carcinoma (BLCA) is the 10th most common cancer with a low survival rate and strong male bias. We studied the field cancerization in BLCA using multi-sample- and multi-tissue-per-patient protocol for sensitive detection of autosomal post-zygotic chromosomal alterations and loss of chromosome Y (LOY). We analysed 277 samples of histologically normal urothelium, 145 tumors and 63 blood samples from 52 males and 15 females, using the in-house adapted Mosaic Chromosomal Alterations (MoChA) pipeline. This approach allows identification of the early aberrations in urothelium from BLCA patients. Overall, 45% of patients exhibited at least one alteration in at least one normal urothelium sample. Recurrence analysis resulted in 16 hotspots composed of either gains and copy number neutral loss of heterozygosity (CN-LOH) or deletions and CN-LOH, encompassing well-known and new BLCA cancer driver genes. Conservative assessment of LOY showed 29%, 27% and 18% of LOY-cells in tumors, blood and normal urothelium, respectively. We provide a proof of principle that our approach can characterize the earliest alterations preconditioning normal urothelium to BLCA development. Frequent LOY in blood and urothelium-derived tissues suggest its involvement in BLCA.
Assessing the New 2020 ESGO/ESTRO/ESP Endometrial Cancer Risk Molecular Categorization System for Predicting Survival and Recurrence
Authors: Ouh Yung-Taek , Oh Yoonji , Joo Jinwon , Woo Joo Hyun , Han Hye Jin , Cho Hyun Woong , Lee Jae Kwan , Chun Yikyeong , Lim Myoung-nam , Hong Jin Hwa
Published: February 2024

This study aimed to evaluate the efficacy of the 2020 European Society of Gynecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology (ESGO/ESTRO/ESP) guidelines for endometrial cancer (EC). Additionally, a novel risk category incorporating clinicopathological and molecular factors was introduced. The predictive value of this new category for recurrence and survival in Korean patients with EC was assessed, and comparisons were made with the 2013 and 2016 European Society of Medical Oncology (ESMO) risk classifications. Patients with EC were categorized into the POLE-mutated (POLEmut), mismatch repair-deficient (MMRd), p53-aberrant (P53abn), and nonspecific molecular profile (NSMP) subtypes. Recurrence, survival, and adjuvant therapy were assessed according to each classification. Notably, patients with the POLEmut subtype showed no relapse, while patients with the P53abn subtype exhibited higher recurrence (31.8%) and mortality rates (31.8%). Regarding adjuvant therapy, 33.3% of low-risk patients were overtreated according to the 2020 ESGO/ESTRO/ESP guidelines. Overall and progression-free survival differed significantly across molecular classifications, with the POLEmut subtype showing the best and the P53abn subtype showing the worst outcomes. The 2020 ESGO molecular classification system demonstrated practical utility and significantly influenced survival outcomes. Immunohistochemistry for TP53 and MMR, along with POLE sequencing, facilitated substantial patient reclassification, underscoring the clinical relevance of molecular risk categories in EC management.
Photodynamic Therapy and Adaptive Immunity Induced by Reactive Oxygen Species: Recent Reports
Authors: Aebisher David , Woźnicki Paweł , Bartusik-Aebisher Dorota
Published: February 2024

Cancer is one of the most significant causes of death worldwide. Despite the rapid development of modern forms of therapy, results are still unsatisfactory. The prognosis is further worsened by the ability of cancer cells to metastasize. Thus, more effective forms of therapy, such as photodynamic therapy, are constantly being developed. The photodynamic therapeutic regimen involves administering a photosensitizer that selectively accumulates in tumor cells or is present in tumor vasculature prior to irradiation with light at a wavelength corresponding to the photosensitizer absorbance, leading to the generation of reactive oxygen species. Reactive oxygen species are responsible for the direct and indirect destruction of cancer cells. Photodynamically induced local inflammation has been shown to have the ability to activate an adaptive immune system response resulting in the destruction of tumor lesions and the creation of an immune memory. This paper focuses on presenting the latest scientific reports on the specific immune response activated by photodynamic therapy. We present newly discovered mechanisms for the induction of the adaptive response by analyzing its various stages, and the possible difficulties in generating it. We also present the results of research over the past 10 years that have focused on improving the immunological efficacy of photodynamic therapy for improved cancer therapy.
Anti-PD-1 Therapy in Advanced Pediatric Malignancies in Nationwide Study: Good Outcome in Skin Melanoma and Hodgkin Lymphoma
Authors: Marjańska Agata , Pawińska-Wąsikowska Katarzyna , Wieczorek Aleksandra , Drogosiewicz Monika , Dembowska-Bagińska Bożenna , Bobeff Katarzyna , Młynarski Wojciech , Adamczewska-Wawrzynowicz Katarzyna , Wachowiak Jacek , Krawczyk Małgorzata , Irga-Jaworska Ninela , Węcławek-Tompol Jadwiga , Kałwak Krzysztof , Sawicka-Żukowska Małgorzata , Krawczuk-Rybak Maryna , Raciborska Anna , Mizia-Malarz Agnieszka , Sobocińska-Mirska Agata , Łaguna Paweł , Balwierz Walentyna , Styczyński Jan
Published: February 2024

Background/aim: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment of childhood cancers is still evolving. The aim of this nationwide retrospective study was to assess the safety and effectiveness of ICIs used in a group of 42 patients, with a median age of 13.6 years, with various types of advanced malignancies treated in pediatric oncology centers in Poland between 2015 and 2023. Results: The indications for treatment with anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); and other malignancies (14). At the end of follow-up, complete remission (CR) was observed in 37.7% (15/42) of children and disease stabilization in 9.5% (4/42), with a mean survival 3.6 (95% CI = 2.6–4.6) years. The best survival (OS = 1.0) was observed in the group of patients with Hodgkin lymphoma. For malignant melanoma of the skin, neuroblastoma, and other rare malignancies, the estimated 3-year OS values were, respectively, 0.78, 0.33, and 0.25 (p = 0.002). The best progression-free survival value (0.78) was observed in the group with malignant melanoma. Significantly better effects of immunotherapy were confirmed in patients ≥ 14 years of age and good overall performance ECOG status. Severe adverse events were observed in 30.9% (13/42) patients.
Oscillatory Hypoxia Can Induce Senescence of Adipose-Derived Mesenchymal Stromal Cells Potentiating Invasive Transformation of Breast Epithelial Cells
Authors: Novin Ashkan , Wali Khadija , Pant Aditya , Liu Shaofei , Du Wenqiang , Liu Yamin , Wang Lichao , Xu Ming , Wang Binsheng , Suhail Yasir , Kshitiz
Published: February 2024

Obesity is strongly associated with occurrence, metastasis, and resistance to therapy in breast cancers, which also exhibit high adipose content in the tumor microenvironment. Adipose tissue-derived mesenchymal stromal cells (ASCs) are recruited to breast cancer by many mechanisms, including hypoxia, and contribute to metastatic transition of the cancer. Breast cancers are characterized by regions of hypoxia, which can be temporally unstable owing to a mismatch between oxygen supply and consumption. Using a high-sensitivity nanopatterned stromal invasion assay, we found that ASCs could promote stromal invasion of not only breast cancer cell lines but also MCF10A1, a cell line derived from untransformed breast epithelium. RNA sequencing of MCF10A1 cells conditioned with medium from ASCs revealed upregulation of genes associated with increased cell migration, chemotaxis, and metastasis. Furthermore, we found that fluctuating or oscillating hypoxia could induce senescence in ASCs, which could result in an increased invasive potential in the treated MCF10A1 cells. These findings highlight the complex interplay within the breast cancer microenvironment, hypoxia, and the role of ASCs in transforming even non-cancerous breast epithelium toward an invasive phenotype, providing insights into early metastatic events.
Association between Cholecystectomy and the Incidence of Pancreaticobiliary Cancer after Endoscopic Choledocholithiasis Management
Authors: Wang Chi-Chih , Huang Jing-Yang , Weng Li-Han , Hsu Yao-Chun , Sung Wen-Wei , Huang Chao-Yen , Lin Chun-Che , Wei James Cheng-Chung , Tsai Ming-Chang
Published: February 2024

(1) Background: Previous studies have raised concerns about a potential increase in pancreaticobiliary cancer risk after cholecystectomy, but few studies have focused on patients who undergo cholecystectomy after receiving endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. This study aims to clarify cancer risks in these patients, who usually require cholecystectomy, to reduce recurrent biliary events. (2) Methods: We conducted a nationwide cohort study linked to the National Health Insurance Research Database, the Cancer Registry Database, and the Death Registry Records to evaluate the risk of pancreaticobiliary cancers. All patients who underwent first-time therapeutic ERCP for choledocholithiasis from 2011 to 2017 in Taiwan were included. We collected the data of 13,413 patients who received cholecystectomy after endoscopic retrograde cholangiopancreatography and used propensity score matching to obtain the data of 13,330 patients in both the cholecystectomy and non-cholecystectomy groups with similar age, gender, and known pancreaticobiliary cancer risk factors. Pancreaticobiliary cancer incidences were further compared. (3) Results: In the cholecystectomy group, 60 patients had cholangiocarcinoma, 61 patients had pancreatic cancer, and 15 patients had ampullary cancer. In the non-cholecystectomy group, 168 cases had cholangiocarcinoma, 101 patients had pancreatic cancer, and 49 patients had ampullary cancer. The incidence rates of cholangiocarcinoma, pancreatic cancer, and ampullary cancer were 1.19, 1.21, and 0.3 per 1000 person-years in the cholecystectomy group, all significantly lower than 3.52 (p < 0.0001), 2.11 (p = 0.0007), and 1.02 (p < 0.0001) per 1000 person-years, respectively, in the non-cholecystectomy group. (4) Conclusions: In patients receiving ERCP for choledocholithiasis, cholecystectomy is associated with a significantly lower risk of developing pancreaticobiliary cancer
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets
Authors: Kouba Bruna R. , de Araujo Borba Laura , Borges de Souza Pedro , Gil-Mohapel Joana , Rodrigues Ana Lúcia S.
Published: February 2024

The involvement of central and peripheral inflammation in the pathogenesis and prognosis of major depressive disorder (MDD) has been demonstrated. The increase of pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, and TNF-α) in individuals with depression may elicit neuroinflammatory processes and peripheral inflammation, mechanisms that, in turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation and gut dysbiosis induce alterations in tryptophan metabolism, culminating in decreased serotonin synthesis, impairments in neuroplasticity-related mechanisms, and glutamate-mediated excitotoxicity. This review aims to highlight the inflammatory mechanisms (neuroinflammation, peripheral inflammation, and gut dysbiosis) involved in the pathophysiology of MDD and to explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines of evidence have indicated that in addition to antidepressants, physical exercise, probiotics, and nutraceuticals (agmatine, ascorbic acid, and vitamin D) possess anti-inflammatory effects that may contribute to their antidepressant properties. Further studies are necessary to explore the therapeutic benefits of these alternative therapies for MDD.