bluuebunny/crossref_metadata_2025 huggingface dataset:
Du Bois and James at Harvard: The Challenges of Fraternal Pairings and Racial Theory
Authors: Ambar Saladin
Published: July 2019

This article seeks to illuminate the relationship between two of the most important figures in American political thought: the pragmatist philosopher William James, and the pioneering civil rights leader and intellectual, W.E.B. Du Bois. As Harvard's first African American PhD, Du Bois was a critical figure in theorizing about race and identity. His innovative take on double consciousness has often been attributed to his contact with James who was one of Du Bois's most critical graduate professors at Harvard. But beyond the view of the two thinkers as intellectual collaborators, is the fraught history of liberal racial fraternal pairing and its role in shaping national identity. This article examines Du Bois and James's relationship in the context of that history, one marked by troubled associations between friendship and race.
-NUMBERS IN FIELDS OF FORMAL POWER SERIES OVER FINITE FIELDS
Authors: KEKEÇ GÜLCAN
Published: July 2019

In the field$\mathbb{K}$of formal power series over a finite field$K$, we consider some lacunary power series with algebraic coefficients in a finite extension of$K(x)$. We show that the values of these series at nonzero algebraic arguments in$\mathbb{K}$are$U$-numbers.
Geochronology, geochemistry and tectonic implications of late Carboniferous Daheyan intrusions from the Bogda Mountains, eastern Tianshan
Authors: Zhang Xuebing , Chai Fengmei , Chen Chuan , Quan Hongyan , Gong Xiaoping
Published: July 2019

The Daheyan region, situated in the SW of the Bogda Mountains in eastern Tianshan, is important for understanding the accretionary history of the Central Asian Orogenic Belt. We investigated Carboniferous intrusions from the Daheyan area, SW Bogda Mountains, obtaining new zircon U–Pb ages, whole-rock geochemical data and Hf isotope data for these intrusions. Zircon U–Pb dating indicates that syenogranite, diorite, granodiorite and monzonite of the Daheyan intrusions were all formed during late Carboniferous (311–303 Ma) magmatism. The syenogranite has geochemical characteristics of A-type granites that were mainly sourced from melting of juvenile crust. In comparison, the low-Mg-number diorite intrusion, with tholeiite and metaluminous features, was derived from young crust and mixed some mantle materials. The granodiorite and monzonite are both I-type granites, and are both sourced from the melting of juvenile crust. Based on a comprehensive analysis of previous geochronological, geochemical and isotopic data of magmatic and sedimentary rocks in the Bogda–Harlik belt, we consider that late Carboniferous intrusive rocks of the Bogda Mountains formed in an intra-arc extension related to a continent-based arc setting.
THE PRIME IDEALS AND SIMPLE MODULES OF THE UNIVERSAL ENVELOPING ALGEBRA U(𝔟⋉V2)
Authors: BAVULA VOLODYMYR V. , LU TAO
Published: July 2019

Let 𝔟 be the Borel subalgebra of the Lie algebra 𝔰𝔩2 and V2 be the simple two-dimensional 𝔰𝔩2-module. For the universal enveloping algebra $\[{\cal A}: = U(\gb \ltimes {V_2})\]$ of the semi-direct product 𝔟⋉V2 of Lie algebras, the prime, primitive and maximal spectra are classified. Please approve edit to the sentence “The sets of completely prime…”.The sets of completely prime ideals of $\[{\cal A}\]$ are described. The simple unfaithful $\[{\cal A}\]$-modules are classified and an explicit description of all prime factor algebras of $\[{\cal A}\]$ is given. The following classes of simple U(𝔟⋉V2)-modules are classified: the Whittaker modules, the 𝕂[X]-torsion modules and the 𝕂[E]-torsion modules.
The phonetic properties of the non-modal phonation in Shanghainese
Authors: Tian Jia , Kuang Jianjing
Published: July 2019

This study investigates the acoustic and articulatory properties of phonation contrast in Shanghainese, the most thoroughly studied Chinese Wu dialect. Although previous studies generally suggest that the non-modal phonation associated with the lower register in Shanghainese is relatively breathier, it is unclear whether it is ‘breathy voice’, ‘slack voice’ or ‘whispery voice’. This study aims to provide a better understanding of the phonetic realization of the non-modal phonation in Shanghainese. Simultaneous audio and electroglottographic recordings were made from 52 speakers born before 1980. Both acoustic and articulatory data confirmed that the non-modal phonation in Shanghainese is produced with relatively less glottal constriction and more aperiodic noise than the modal phonation. The novel finding of this study is that aperiodic noise plays a much more important role than spectral measures (i.e. indicators of glottal constriction) in the phonetic realization of the non-modal phonation. This property is distinct from the breathier voices in Gujarati, White Hmong and Southern Yi. These results suggest that the non-modal phonation in Shanghainese should be characterized as ‘whispery voice’, which is phonetically distinct from both ‘breathy voice’ and ‘slack voice’.
Do the cures match the problem? Reforming the Arctic Council
Authors: Smieszek Malgorzata
Published: July 2019

Despite its numerous valuable contributions to Arctic governance, throughout its history the Arctic Council (AC) has been subject to criticism and reform proposals from academic, non-governmental and practitioner communities alike. In order to inform this ongoing debate, the paper evaluates the proposals that have been presented for the AC thus far. The proposals are grouped into three clusters: legal reforms, organisational reforms and functional reforms. Each of them is examined in terms of its applicability and usefulness to the case of the AC, and specifically its suitability given the prevailing conditions in the Arctic. What the conducted analysis reveals is that the ideas regarding means to enhance the AC’s effectiveness can be largely attributed to the assumptions their proponents make—oftentimes implicitly—about the nature of state actors and international relations more broadly, without attending to the particular conditions of the case study at hand. This is an important inference, given the unrelenting change happening in both Arctic and global socio-environmental settings that calls into question the usefulness of past modes of thinking and forms of international cooperation. Far from offering solutions, their continuous application in particular circumstances might even impede progress in addressing present and future challenges.
‘The view from above’: a theory of comparative philosophy
Authors: FRAZIER JESSICA
Published: July 2019

What if doing philosophy across cultures is always implicitly a matter of metaphilosophy – of articulating more clearly the nature of philosophy itself? What if it forces us to ‘stand back’ hermeneutically and map out a ‘view from above’ of the underlying fabric of ideas – in their constitutive concepts, their relations to other ways of thinking, and their potential to be configured in alternative fascinating and fruitful ways?

This article incorporates existing approaches to comparative philosophy within a single scheme of complementary philosophical activities, and a single overarching metaphilosophical project. These approaches are (1) ‘archival’ (exploring parallel but separate philosophical traditions), (2) ‘equivalentist’ (comparing traditions in terms of analogies and contrasts), and (3) ‘problem-solving’ (using multiple traditions to provide philosophical solutions). I situate these within (4) the overarching hermeneutic project of ‘mapping’ concepts and their possibilities. This entails the theory that philosophies drawing on multiple perspectives are always implicitly engaged in mapping out the underlying eidetic structure upon which philosophy does its work, and charting the conceptual possibilities surrounding any idea.
Emergent sociolinguistic variation in severe language endangerment
Authors: Kasstan Jonathan R.
Published: July 2019

Contrary to Labov'sprinciple of style shifting, studies in language obsolescence portray speakers of dying languages as ‘monostylistic’, a characterization questioned here. Variationist methodology is adopted in a context of gradual language death. By combining quantitative and interactional analyses of data from older, younger, and new speakers of Francoprovençal in France and Switzerland, the article considers (a) to what extent variability in language obsolescence differs from that found in ‘healthy’ languages, and (b) how innovations might spread through communities speaking threatened languages characterized as ‘monostylistic’ and lacking overt normative infrastructure. It is argued that style variation (not monostylism) emerges from linguistic decay: among more fluent speakers, a categorical rule of /l/-palatalization before obstruents becomes underspecified, rendering palatalization available for strategic use. Among new speakers, novel palatal variants form part of an emergent sociolinguistic norm. The study offers fresh insights on the origins of sociolinguistic variation with implications for variationist theory. (Language obsolescence, language death, language variation and change, style variation, new speakers)*
Teacher written corrective feedback: Less is more
Authors: Lee Icy
Published: July 2019

In different parts of the world second language (L2) teachers devote a massive amount of time to giving feedback on grammatical errors in student writing. Such written corrective feedback, which is unfocused and comprehensive, is fraught with problems for both teachers and students. Nonetheless, it remains a prevalent practice in many L2 contexts. In this position paper, I argue that more written corrective feedback is not better, but instead less is more. After presenting the problems emanating from comprehensive written corrective feedback, I argue for a focused approach to written corrective feedback and examine its benefits for teachers and students. Through discussing five impediments to the implementation of focused written corrective feedback, I scrutinize and refute the counter-claims, and bolster my overall argument in support of focused written corrective feedback. I conclude the position paper with recommendations for action for teachers, teacher educators and researchers.
Influences of victimization and comorbid conditions on substance use disorder outcomes in justice-involved youth: A discrete time survival mixture analysis
Authors: Davis Jordan P. , Janssen Tim , Dworkin Emily R. , Dumas Tara M. , Goldbach Jeremy , Monterosso John
Published: July 2019

To understand how exposure to victimization during adolescence and the presence of comorbid psychological conditions influence substance use treatment entry and substance use disorder diagnosis from 14 to 25 years old among serious juvenile offenders, this study included 1,354 serious juvenile offenders who were prospectively followed over 7 years. Growth mixture modeling was used to assess profiles of early victimization during adolescence (14–17 years). Discrete time survival mixture analysis was used to assess time to treatment entry and substance use disorder diagnosis. Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) were used as predictors of survival time. Mixture models revealed three profiles of victimization: sustained poly-victimization, moderate/decreasing victimization, and low victimization. Youth in the sustained poly-victimization class were more likely to enter treatment earlier and have a substance use diagnosis earlier than other classes. PTSD was a significant predictor of treatment entry for youth in the sustained poly-victimization class, and MDD was a significant predictor of substance use disorder diagnosis for youth in the moderate/decreasing victimization class. Therefore, substance use prevention programming targeted at youth experiencing poly-victimization in early adolescence—especially those who have PTSD or MDD—is needed.
The variable palatal lateral in Occitan and Catalan: linguistic transfer or regular sound change?
Authors: Mooney Damien , Hawkey James
Published: July 2019

Occitan and Catalan are in an increasing state of language obsolescence in France. Their phonologies both contain a voiced palatal lateral approximant /ʎ/, not present in modern French, that is being replaced in all positions by the palatal approximant [j]. It is not clear whether this is an effect of language contact with French because [j] commonly emerges as a variant of /ʎ/ in non-contact varieties of Romance. This article examines the distribution of /ʎ/ in Occitan and Catalan, using auditory and acoustic data from a wordlist-translation task conducted with 40 native speakers. The analysis aims to determine the nature of this sound change either as the result of transfer from French or as a regular sound change that is motivated by the phonetic similarity of [ʎ] and [j]. The mechanisms governing transfer from French are modelled statistically to account for the distribution of historically appropriate and contact-induced variants of /ʎ/, and acoustic analyses test the hypothesis that the change is internally motivated and occurring gradually. Results show that the factors conditioning the change may be different in each of these related languages in that it is contact-induced in Occitan, but potentially due to internal and external factors in Catalan.
Beyond obsolescence: a twenty-first century research agenda for thelangues régionales
Authors: Hall Damien , Kasstan Jonathan R. , Hornsby David
Published: July 2019

This Special Issue of theJournal of French Language Studiescelebrates a recent surge in enthusiasm for sociolinguistic studies involving the regional languages of France. Taking our cue from the contributions to the volume, which we introduce here, we argue that a changing twenty-first century landscape offers an exciting new agenda for these regional languages (and minority languages more widely), and set out what we see as six key directions for contemporary research.
Sentential Negation in North-eastern Gallo-Romance dialects: insights from the Atlas Linguistique de la France
Authors: Burnett Heather
Published: July 2019

This article argues that data from the Atlas Linguistique de la France (ALF, Edmont and Gilliéron, 1902–1910) can shed light on the fine-grained syntax of sentential negation in the Oïl dialects spoken in North Eastern France, Belgium and Switzerland. The Gallo-Romance dialects spoken in this area possess a larger variety of negative structures than those found in (Standard) French: in addition tone…pas,necan be followed by negationsmie,pontor even appear alone. Although the dialects under study are highly endangered, I show how we can use syntactic data ‘hidden’ in the ALF to study their syntactic patterns. I present a quantitative study of variation in sentential negation in authentic transcriptions and French translations of the 22 negative data points in the ALF at 150 points in France, Belgium and Switzerland (N = 2989). I show that thepontform is significantly more frequent in negative constructions with ‘weak NPs’ (dephrases) and that there is a significant correlation between dropping of secondary negation and the ability of the secondary negationmieto be realized as an enclitic-m. This study supports Dagnac (2018)’s conclusion that the ALF is an invaluable tool for the study of syntactic microvariation in France.
Peak Freedgood
Authors: Schmitt Cannon
Published: July 2019

The allusion in my title, of course, is to Marion King Hubbert's theory of “peak oil,” that moment in history when petroleum production reaches maximum output and then begins to decline. But Peak Freedgood is not Time's fool. It is an ever-fixèd mark: a quality or an intensity rather than a quantity; a stretch of Elaine Freedgood's work in which she is most like herself—when Elaineness production reaches maximum output. Such passages can be encountered in every book and article she's ever published, but the one I'll start with appears in a 2010New Literary Historyessay called “Fictional Settlements” focused on Catharine Parr Traill'sCanadian Crusoes(1852).
On Metalepsis
Authors: Xin Wendy Veronica
Published: July 2019

Even before I heard about this celebration of Elaine Freedgood's work and mentorship, I was already thinking about how I'd come to know her and about the numerous ways she has shaped my writing and my writing life. This reflection was prompted, inadvertently, by Elaine herself. A little while back, Elaine wrote me an email with the always-thoughtful subject line, “How are you, my friend?” Except, Elaine had forgotten the comma after “you,” so it read instead, “How are you my friend?” This message made me laugh, as did her subsequent response about leaving out that crucial comma. Elaine came to be an unusually generous mentor through the most usual of circumstances. I was first put in touch with her when she came to Berkeley to give a talk called “The Secret Life of Diegesis,” five years ago. I have a vivid memory of the emails we'd exchanged about booking flights and reserving hotel rooms and all that—usually these would be somewhat tedious issues to sort through, but Elaine's typically dry humor enlivened even the driest of topics. When asked if she wanted to “be a trooper” and take a red-eye over to the West Coast, she responded, “Thanks so much. I would be a trooper if necessary but of course would rather be a pathetic middle-aged person (i.e., myself).”
How do Public Policy-makers Perceive National Quality Infrastructure? The Case of Serbia as an EU Pre-accession Country
Authors: Ruso Jelena , Filipovic Jovan
Published: July 2019

In this article, we develop a framework for a comparative analysis of policy-making in the EU pre- and post-accession CEE countries (CEECs) in order to create generalized knowledge in some particular areas, such as quality infrastructure (QI). In order to find how public policy-makers perceive QI, we employ a triangulation methodology. The results show that policy-makers are not fully familiar with national QI concepts and seldom rely on experts’ opinion. Moreover, QI legislation is uncritically transferred from the EU.
GENERALIZED JORDAN DERIVATIONS ON SEMIPRIME RINGS
Authors: FERREIRA BRUNO L. M. , FERREIRA RUTH N. , GUZZO HENRIQUE
Published: July 2019

The purpose of this note is to prove the following. Suppose $\mathfrak{R}$ is a semiprime unity ring having an idempotent element $e$ ($e\neq 0,~e\neq 1$) which satisfies mild conditions. It is shown that every additive generalized Jordan derivation on $\mathfrak{R}$ is a generalized derivation.
Indigenous Women's Activism, Ecofeminism, and Extractivism: Partial Connections in the Ecuadorian Amazon
Authors: Sempértegui Andrea
Published: July 2019

Over the last two decades, Latin America has witnessed a massive expansion of resource extraction. One of the most significant countermovements to emerge out of this context in Ecuador features a strong base and leadership of indigenous women from the Amazon. In their collective effort to resist extractivism, Amazonian women have drawn from elements of ecofeminist discourse and, in the process, situated their own claims within the broader indigenous territorial struggle. Ecofeminism has been transformed through this allyship as well, becoming more inclusive of indigenous women's perspectives. To shed light on these complex relationships, this article applies the framework of “partial connection” from feminist anthropology. It shows how postcolonial encounters between the state, missionaries, environmental activists, and indigenous communities in the Amazon carved out unique spaces for indigenous self-organization and politics. The historical analysis of such spaces, I argue, is crucial for grasping the allyship between Amazonian women and ecofeminists today. Rooted in a combination of positions that are partially, asymmetrically, and ambiguously connected, the allyship between Amazonian women and ecofeminists is best understood as a form of partially connected relationship.
The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update
Authors: Gatz Margaret , Plassman Brenda L. , Tanner Caroline M. , Goldman Samuel M. , Swan Gary E. , Chanti-Ketterl Marianne , Walters Ellen E. , Butler David A.
Published: July 2019

The National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917–1927 (N = 31.848), both of whom served in the armed forces, chiefly during World War II. This article updates activities in this registry since the most recent report in Twin Research and Human Genetics (Page, 2006). Records-based data include information from enlistment charts and Veterans Administration data linkages. There have been three major epidemiologic questionnaires and an education and earnings survey. Separate data collection efforts with the NAS-NRC registry include the National Heart, Lung, and Blood Institute (NHLBI) subsample, the Duke Twins Study of Memory in Aging and a clinically based study of Parkinson’s disease. Progress has been made on consolidating the various data holdings of the NAS-NRC Twin Registry. Data that had been available through the National Academy of Sciences are now freely available through National Archive of Computerized Data on Aging (NACDA).
Carolina redroot (Lachnanthes caroliniana) vegetative growth and rhizome production as affected by environmental factors and planting depth
Authors: Besançon Thierry. E.
Published: July 2019

Carolina redroot [Lachnanthes caroliniana (Lam.) Dandy] is a frequent weed of New Jersey cranberry (Vaccinium macrocarpon Aiton) bogs that competes with the crop for nutritional resources. Studies were conducted in 2018 to determine the effects of planting depth, soil moisture, lighting conditions, rhizome water content, and duration of rhizome submersion under water on L. caroliniana shoot emergence, vegetative growth, and rhizome development. Only planting depth greater than 12 cm significantly reduced shoot emergence (54%), biomass shoot and root production (27% and 65%, respectively), and rhizome formation (65%) compared with a 2-cm depth. Complete inhibition of new rhizome production was observed when the rhizome water content dropped to 30%. Soil moisture ≤30% decreased shoot biomass by ≥53% compared to 60% soil moisture, but marginally affected root biomass and had no impact on rhizome formation. Rhizome submersion for at least 120 d had minor effect on shoot emergence but reduced plant biomass by ≥28% and completely inhibited the formation of rhizomes. Finally, shading did not influence emergence but had a more dramatic effect on root and shoot biomass, which were reduced by 53% and 75%, respectively, and prevented the development of new rhizomes. This study demonstrates the plasticity of L. caroliniana to drought stress or long-lasting flooding conditions, therefore preventing consideration of cranberry bed temporary flooding or limitation of irrigation volume and frequency as viable management options. Sanding would not provide a layer of material sufficiently thick for reducing L. caroliniana shoot emergence. Reducing the quantity of light reaching the soil with black tarps or promoting rapid crop canopy closure are options that can complement the use of mesotrione for controlling L. caroliniana. Future research should address the practicality of these options, especially in bogs with low L. caroliniana pressure when early-summer weed regrowth occurs following dissipation of PRE herbicide activity.
Space Radiation and Plasma Effects on Satellites and Aviation: Quantities and Metrics for Tracking Performance of Space Weather Environment Models
Authors: Zheng Yihua , Ganushkina Natalia Yu , Jiggens Pier , Jun Insoo , Meier Matthias , Minow Joseph I. , O'Brien T. Paul , Pitchford Dave , Shprits Yuri , Tobiska W. Kent , Xapsos Michael A. , Guild Timothy B. , Mazur Joseph E. , Kuznetsova Maria M.
Published: July 2019

The Community Coordinated Modeling Center has been leading community‐wide space science and space weather model validation projects for many years. These efforts have been broadened and extended via the newly launched International Forum for Space Weather Modeling Capabilities Assessment (https://ccmc.gsfc.nasa.gov/assessment/). Its objective is to track space weather models' progress and performance over time, a capability that is critically needed in space weather operations and different user communities in general. The Space Radiation and Plasma Effects Working Team of the aforementioned International Forum works on one of the many focused evaluation topics and deals with five different subtopics (https://ccmc.gsfc.nasa.gov/assessment/topics/radiation‐all.php) and varieties of particle populations: Surface Charging from tens of eV to 50‐keV electrons and internal charging due to energetic electrons from hundreds keV to several MeVs. Single‐event effects from solar energetic particles and galactic cosmic rays (several MeV to TeV), total dose due to accumulation of doses from electrons (>100 keV) and protons (>1 MeV) in a broad energy range, and radiation effects from solar energetic particles and galactic cosmic rays at aviation altitudes. A unique aspect of the Space Radiation and Plasma Effects focus area is that it bridges the space environments, engineering, and user communities. The intent of the paper is to provide an overview of the current status and to suggest a guide for how to best validate space environment models for operational/engineering use, which includes selection of essential space environment and effect quantities and appropriate metrics.
Observed El Niño‐La Niña Asymmetry in a Linear Model
Authors: Martinez‐Villalobos Cristian , Newman Matthew , Vimont Daniel J. , Penland Cécile , David Neelin J.
Published: July 2019

Previous studies indicate an asymmetry in the amplitude and persistence of El Niño (EN) and La Niña (LN) events. We show that this observed EN‐LN asymmetry can be captured with a linear model driven by correlated additive and multiplicative (CAM) noise, without resorting to a deterministic nonlinear model. The model is derived from 1‐month lag statistics taken from monthly sea surface temperature (SST) data sets spanning the twentieth century, in an extension of an empirical‐dynamical technique called Linear Inverse Modeling. Our results suggest that noise amplitudes tend to be stronger for EN compared to LN events, which is sufficient to generate asymmetry in amplitude and also produces more persistent LN events on average. These results establish a null hypothesis for EN‐LN asymmetry and suggest that strong EN events may not be more predictable that what can be accounted for by a multivariate linear system driven by CAM noise.
Pn Tomography of the Juan de Fuca and Gorda Plates: Implications for Mantle Deformation and Hydration in the Oceanic Lithosphere
Authors: VanderBeek Brandon P. , Toomey Douglas R.
Published: July 2019

Tomographic analysis of Pn arrivals—the guided P wave propagating within the lithospheric mantle—is ideal for studying uppermost mantle structure. While plate‐scale seismic images of Pn velocities are common beneath the continents, similar scale studies have not been possible within ocean basins due to the sparse distribution of seismic stations. The Cascadia Initiative (CI) data set provides the first opportunity to image spatial variations in lithospheric structure from accretion to subduction across an entire oceanic plate. We invert Pn travel times from local earthquakes for 3‐D variations in isotropic and anisotropic P wave velocity and event hypocentral parameters. Despite surficial evidence of extensive faulting, we find that the velocity structure of the Gorda uppermost mantle is remarkably consistent with predictions from a conductive cooling model. Limited brittle deformation at mantle depths is supported by seismic anisotropy measurements, which show the fast direction of P wave propagation rotates in concert with the magnetic anomaly lineations. This rotation may be explained by local plate kinematics without internal deformation and hydration of the shallow mantle. In contrast to Gorda, the seismic velocity structure of the Juan de Fuca (JdF) plate does not exhibit a clear age dependence. Anomalously slow mantle velocities are found along the southern edge of the JdF plate and are spatially associated with the termini of pseudofaults. We attribute these velocity reductions to mantle alteration by seawater. Our results highlight the heterogeneous nature of the oceanic mantle lithosphere and show that patterns of mantle alteration are not readily discerned from surficial indicators of seafloor deformation.
Correlation Between the First Return Stroke of Negative CG Lightning and Its Preceding Discharge Processes
Authors: Shi Dongdong , Wang Daohong , Wu Ting , Takagi Nobuyuki
Published: July 2019

Using the negative cloud‐to‐ground lightning cases well located by the Fast Antenna Lightning Mapping Array, we have examined the general characteristics of the preliminary breakdown (PB) and stepped leader (SL) processes, and further studied the correlation between the first return stroke (RS1st) intensity and its preceding discharge processes. The RS1st intensity is measured from the range‐normalized radiation field. The parameters used to characterize PB/SL include PB altitude, PB/SL vertical speed, PB/SL pulse rate, and SL duration. The arithmetic mean PB altitude is about 5.6 km and exhibits a weak inverse correlation with the RS1st intensity. As the PB develops into the SL, the arithmetic mean vertical speed decreases from 4.7 × 105 to 1.7 × 105 m/s and the arithmetic mean pulse rate reduces from 5.1 to 2.4 ms−1. In the PB/SL processes, the average vertical speed and pulse rate have positive correlations with the RS1st intensity while the corresponding Spearman's correlation coefficient for SL is considerably larger than that for PB. The average SL duration is 34 ms and has a negative relation to the RS1st intensity, with the coefficient of −0.71. These results demonstrate that on average, lower initiation altitude, faster PB/SL vertical speed, higher PB/SL pulse rate, and shorter SL duration tend to be followed by stronger RS1st. According to the above correlations, we speculate that the combination of a middle negative charge region with a uniform and wide horizontal distribution and a small lower positive charge region is a favorable condition for an intense RS1st.
River Bed Elevation Variability Reflects Sediment Supply, Rather Than Peak Flows, in the Uplands of Washington State
Authors: Pfeiffer Allison M. , Collins Brian D. , Anderson Scott W. , Montgomery David R. , Istanbulluoglu Erkan
Published: July 2019

River channel beds aggrade and incise through time in response to temporal variation in the upstream supply of water and sediment. However, we lack a thorough understanding of which of these is the dominant driver of channel bed elevation change. This lack hampers flood hazard prediction, as changes to the bed elevation can either augment or reduce flood heights. Here, we explore the drivers of channel change using multidecadal time series of river bed elevation at 49 United States Geological Survey (USGS) gage sites in the uplands of Washington State, USA. We find that channel bed elevations at many of the gages change remarkably little over >80 years, while others are highly unstable. Despite regionally synchronous decadal fluctuations in flood intensity, there is a lack of regional synchrony of channel response at the decadal scale. At the monthly scale, the magnitude of antecedent high flow events between gage measurements does not predict either the direction or magnitude of shift in channel bed elevation. That variations in flood magnitude are insufficient to explain changes in bed elevation suggests that fluctuations in sediment supply, rather than variation in peak flows, are the primary driver of change to river bed elevation. In this region, channels downstream from glaciers have statistically significantly greater variability in bed elevation compared to those lacking upstream glaciers. Together, these findings suggest that aggradation and incision signals in this region predominately reflect fluctuations in sediment supply, commonly associated with glaciogenic sources, rather than response to high flow events.
SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis
Authors: Kim Hwan , Oh Hyejin , Oh Young Soo , Bae Jeomil , Hong Nan Hyung , Park Su Jung , Ahn Suyeon , Lee Miriam , Rhee Sangmyung , Lee Sung Haeng , Jun Youngsoo , Kim Sung Hyun , Huh Yun Hyun , Song Woo Keun
Published: July 2019

During ligand-mediated receptor endocytosis, the small GTPase Rab5 functions in vesicle fusion and trafficking. Rab5 activation is known to require interactions with its guanine nucleotide-exchange factors (GEFs); however, the mechanism regulating Rab5 interactions with GEFs remains unclear. Here, we show that the SH3-adapter protein SPIN90 participates in the activation of Rab5 through the recruitment of both Rab5 and its GEF, Gapex5, to endosomal membranes during epidermal growth factor (EGF)-mediated endocytosis. SPIN90 strongly interacts with the inactive Rab5/GDI2 complex through its C-terminus. In response to EGF signaling, extracellular signal-regulated kinase (ERK)-mediated phosphorylation of SPIN90 at Thr-242 enables SPIN90 to bind Gapex5 through its N-terminal SH3 domain. Gapex5 is a determinant of Rab5 membrane targeting, while SPIN90 mediates the interaction between Gapex5 and Rab5 in a phosphorylation-dependent manner. Collectively, our findings suggest that SPIN90, as an adaptor protein, simultaneously binds inactive Rab5 and Gapex5, thereby altering their spatial proximity and facilitating Rab5 activation.
Do we need race-specific resting metabolic rate prediction equations?
Authors: Reneau James , Obi Brittaney , Moosreiner Andrea , Kidambi Srividya
Published: July 2019

Background

Resting metabolic rate (RMR) is a key determinant of daily caloric needs. Respirometry, a form of indirect calorimetry (IC), is considered one of the most accurate methods to measure RMR in clinical and research settings. It is impractical to measure RMR by IC in routine clinical practice; therefore, several formulas are used to predict RMR. In this study, we sought to determine the accuracy of these formulas in determining RMR and assess additional factors that may determine RMR.

Methods

We measured RMR in 114 subjects (67% female, 30% African American [AA]) using IC. Along with standard anthropometrics, dual-energy X-ray absorptiometry was used to obtain fat-free mass(FFM) and total fat mass. Measured RMR (mRMR) by respirometry was compared with predicted RMR (pRMR) generated by Mifflin–St.Joer, Cunningham, and Harris–Benedict (HB) equations. Linear regression models were used to determine factors affecting mRMR.

Results

Mean age, BMI, and mRMR of subjects were 46 ± 16 years (mean ± SD), 35 ± 10 kg/m2, and 1658 ± 391 kcal/day, respectively. After adjusting for age, gender, and anthropometrics, the two largest predictors of mRMR were race (p < 0.0001) and FFM (p < 0.0001). For every kg increase in FFM, RMR increased by 28 kcal/day (p < 0.0001). AA race was associated with 144 kcal/day (p < 0.0001) decrease in mRMR. The impact of race on mRMR was mitigated by adding in truncal FFM to the model. When using only clinically measured variables to predict mRMR, we found race, hip circumference, age, gender, and weight to be significant predictors of mRMR (p < 0.005). Mifflin–St.Joer and HB equations that use just age, gender, height, and weight overestimated kcal expenditure in AA by 138 ± 148 and 242 ± 164 (p < 0.0001), respectively.

Conclusion

We found that formulas utilizing height, weight, gender, and age systematically overestimate mRMR and hence predict higher calorie needs among AA. The lower mRMR in AA could be related to truncal fat-free mass representing the activity of metabolically active intraabdominal organs.
Local biotic interactions drive species-specific divergence in soil bacterial communities
Authors: Zhao Xin-Feng , Hao Yi-Qi , Zhang Da-Yong , Zhang Quan-Guo
Published: July 2019

It is well accepted that environmental heterogeneity and dispersal are key factors determining soil bacterial community composition, yet little is known about the role of local biotic interactions. Here we address this issue with an abundance-manipulation experiment that was conducted in a semiarid grassland. We manually increased the abundance of six randomly chosen resident bacterial species in separate, closed, communities and allowed the communities to recover in situ for 1 year. The single episode of increase in the abundance of different species drove species-specific community divergence accompanied by a decline in local diversity. Four of the six added species caused a decrease in the abundance of their closely related species, suggesting an important role of interspecific competition in driving the observed community divergence. Our results also suggested a lack of effective population regulations to force the relative abundance of manipulated species to revert to original level, which would allow persistence of the divergence among soil bacterial communities. We concluded that biotic interactions were important in determining soil bacterial community composition, which could result in substantial variation in soil bacterial community composition in abiotically homogenous environment.
Benefits of additional cycles of bortezomib/thalidomide/dexamethasone (VTD) induction therapy compared to four cycles of VTD for newly diagnosed multiple myeloma
Authors: Lee Yoo Jin , Moon Joon Ho , Sohn Sang Kyun , Kim Seok Jin , Jung Sung-Hoon , Lee Je-Jung , Jo Jae-Cheol , Shin Ho-Jin , Lee Won Sik , Lee Ji Hyun , Bae Sung Hwa , Kim Min Kyoung , Lee Ho Sup , Kim Kihyun , Min Chang-Ki ,   The Korean Multiple Myeloma Working Party
Published: July 2019

Bortezomib/thalidomide/dexamethasone (VTD) induction therapy followed by autologous stem cell transplantation (ASCT) is one of the standard therapies for newly diagnosed multiple myeloma (NDMM). However, the appropriate depth of response to induction therapy and timing of upfront ASCT are still debated. We investigated if two additional cycles of VTD (VTD6) improved the responses and progression-free survival (PFS) compared with four cycles of VTD (VTD4). We retrospectively reviewed outcomes of 190 NDMM patients treated with at least four cycles of VTD followed by ASCT between September 2014 and August 2017 [VTD4, n = 129 (67.9%); VTD6, n = 61 (32.1%)]. The VTD6 group had a higher pre-ASCT complete response (CR) rate than the VTD4 group (31.1% versus 10.1%, P < 0.001), but, the pre- and post-ASCT ≥ very good partial response (VGPR), and 2-year PFS were similar. Multivariate analysis revealed age, β2-microglobulin, and pre-ASCT CR as important factors for PFS. Two additional cycles of VTD prolonged PFS in patients with PR only after VTD4 [Hazard ratio (HR) = 0.29, P = 0.016] or those with Revised International Staging System stage I/II (HR = 0.36, P = 0.039). In conclusion, two additional VTD cycles may be helpful for patients with PR only after VTD4 but high risk MM needs the other treatment options.
Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling
Authors: Seyfried Felix , Demir Salih , Hörl Rebecca Louise , Stirnweiß Felix Uli , Ryan Jeremy , Scheffold Annika , Villalobos-Ortiz Mariana , Boldrin Elena , Zinngrebe Julia , Enzenmüller Stefanie , Jenni Silvia , Tsai Yi-Chien , Bornhauser Beat , Fürstberger Axel , Kraus Johann Michael , Kestler Hans Armin , Bourquin Jean-Pierre , Stilgenbauer Stephan , Letai Anthony , Debatin Klaus-Michael , Meyer Lüder Hinrich
Published: July 2019

Deregulated cell death pathways contribute to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Intrinsic apoptosis signaling is regulated by different proapoptotic and antiapoptotic molecules: proapoptotic BCL-2 homology domain 3 (BH3) proteins activate prodeath molecules leading to cellular death, while antiapoptotic molecules including B-cell lymphoma 2 (BCL-2) prevent activation of prodeath proteins and counter-regulate apoptosis induction. Inhibition of these antiapoptotic regulators has become a promising strategy for anticancer treatment, but variable anticancer activities in different malignancies indicate the need for upfront identification of responsive patients. Here, we investigated the activity of the BCL-2 inhibitor venetoclax (VEN, ABT-199) in B-cell precursor acute lymphoblastic leukemia and found heterogeneous sensitivities in BCP-ALL cell lines and in a series of patient-derived primografts. To identify parameters of sensitivity and resistance, we evaluated genetic aberrations, gene-expression profiles, expression levels of apoptosis regulators, and functional apoptosis parameters analyzed by mitochondrial profiling using recombinant BH3-like peptides. Importantly, ex vivo VEN sensitivity was most accurately associated with functional BCL-2 dependence detected by BH3 profiling. Modeling clinical application of VEN in a preclinical trial in a set of individual ALL primografts, we identified that leukemia-free survival of VEN treated mice was precisely determined by functional BCL-2 dependence. Moreover, the predictive value of ex vivo measured functional BCL-2 dependence for preclinical in vivo VEN response was confirmed in an independent set of primograft ALL including T- and high risk-ALL. Thus, integrative analysis of the apoptosis signaling indicating mitochondrial addiction to BCL-2 accurately predicts antileukemia activity of VEN, robustly identifies VEN-responsive patients, and provides information for stratification and clinical guidance in future clinical applications of VEN in patients with ALL.
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Authors: Tian Yuan , Yang Bin , Qiu Weinan , Hao Yajing , Zhang Zhenxing , Yang Bo , Li Nan , Cheng Shuqun , Lin Zhangjun , Rui Yao-cheng , Cheung Otto K. W. , Yang Weiqin , Wu William K. K. , Cheung Yue-Sun , Lai Paul B. S. , Luo Jianjun , Sung Joseph J. Y. , Chen Runsheng , Wang Hong-Yang , Cheng Alfred S. L. , Yang Pengyuan
Published: July 2019

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells, the deregulated metabolic modulation of HCC cells in the NAFLD progression remains obscure. Here, we discovers an endoplasmic reticulum-residential protein, Nogo-B, as a highly expressed metabolic modulator in both murine and human NAFLD-associated HCCs, which accelerates high-fat, high-carbohydrate diet-induced metabolic dysfunction and tumorigenicity. Mechanistically, CD36-mediated oxLDL uptake triggers CEBPβ expression to directly upregulate Nogo-B, which interacts with ATG5 to promote lipophagy leading to lysophosphatidic acid-enhanced YAP oncogenic activity. This CD36-Nogo-B-YAP pathway consequently reprograms oxLDL metabolism and induces carcinogenetic signaling for NAFLD-associated HCCs. Targeting the Nogo-B pathway may represent a therapeutic strategy for HCC arising from the metabolic syndrome.
A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
Authors: Wang Junlin , Zhang Yanan , Liu Huanhuan , Shang Yong , Zhou Linjun , Wei Penglin , Yin Wen-Bing , Deng Zixin , Qu Xudong , Zhou Qianghui
Published: July 2019

Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-OH-cortexolone in 80% efficiency at the multi-gram scale. The obtained C19-OH-cortexolone can be readily transformed to various synthetically useful intermediates including the industrially valuable 19-OH-androstenedione, which can serve as a basis for synthesis of C19-functionalized steroids as well as 19-nor steroidal drugs. Using this biocatalytic C19-hydroxylation method, the unified synthesis of six C19-hydroxylated pregnanes is achieved in just 4 to 9 steps. In addition, the structure of sclerosteroid B is revised on the basis of our synthesis.
Lack of long-term acclimation in Antarctic encrusting species suggests vulnerability to warming
Authors: Clark Melody S. , Villota Nieva Leyre , Hoffman Joseph I. , Davies Andrew J. , Trivedi Urmi H. , Turner Frances , Ashton Gail V. , Peck Lloyd S.
Published: July 2019

Marine encrusting communities play vital roles in benthic ecosystems and have major economic implications with regards to biofouling. However, their ability to persist under projected warming scenarios remains poorly understood and is difficult to study under realistic conditions. Here, using heated settlement panel technologies, we show that after 18 months Antarctic encrusting communities do not acclimate to either +1 °C or +2 °C above ambient temperatures. There is significant up-regulation of the cellular stress response in warmed animals, their upper lethal temperatures decline with increasing ambient temperature and population genetic analyses show little evidence of differential survival of genotypes with treatment. By contrast, biofilm bacterial communities show no significant differences in community structure with temperature. Thus, metazoan and bacterial responses differ dramatically, suggesting that ecosystem responses to future climate change are likely to be far more complex than previously anticipated.
Ultrasound experiments on acoustical activity in chiral mechanical metamaterials
Authors: Frenzel Tobias , Köpfler Julian , Jung Erik , Kadic Muamer , Wegener Martin
Published: July 2019

Optical activity requires chirality and is a paradigm for chirality. Here, we present experiments on its mechanical counterpart, acoustical activity. The notion “activity” refers the rotation of the linear polarization axis of a transversely polarized (optical or mechanical) wave. The rotation angle is proportional to the propagation distance and does not depend on the orientation of the incident linear polarization. This kind of reciprocal polarization rotation is distinct from nonreciprocal Faraday rotation, which requires broken time-inversion symmetry. In our experiments, we spatiotemporally resolve the motion of three-dimensional chiral microstructured polymer metamaterials, with nanometer precision and under time-harmonic excitation at ultrasound frequencies in the range from 20 to 180 kHz. We demonstrate polarization rotations as large as 22° per unit cell. These experiments pave the road for molding the polarization and direction of elastic waves in three dimensions by micropolar mechanical metamaterials.
Quantum tomography of electrical currents
Authors: Bisognin R. , Marguerite A. , Roussel B. , Kumar M. , Cabart C. , Chapdelaine C. , Mohammad-Djafari A. , Berroir J.-M. , Bocquillon E. , Plaçais B. , Cavanna A. , Gennser U. , Jin Y. , Degiovanni P. , Fève G.
Published: July 2019

In quantum nanoelectronics, time-dependent electrical currents are built from few elementary excitations emitted with well-defined wavefunctions. However, despite the realization of sources generating quantized numbers of excitations, and despite the development of the theoretical framework of time-dependent quantum electronics, extracting electron and hole wavefunctions from electrical currents has so far remained out of reach, both at the theoretical and experimental levels. In this work, we demonstrate a quantum tomography protocol which extracts the generated electron and hole wavefunctions and their emission probabilities from any electrical current. It combines two-particle interferometry with signal processing. Using our technique, we extract the wavefunctions generated by trains of Lorentzian pulses carrying one or two electrons. By demonstrating the synthesis and complete characterization of electronic wavefunctions in conductors, this work offers perspectives for quantum information processing with electrical currents and for investigating basic quantum physics in many-body systems.