bluuebunny/crossref_metadata_2025 huggingface dataset:
ON NUMEROV METHOD FOR SOLVING FOURTH ORDER ORDINARY DIFFERENTIAL EQUATIONS
Authors: Ndanusa Abdulrahman , Adeboye K. R. , Mustapha A. U. , Abdullahi R.
Published: June 2021

In this work, a fourth order ODE of the form  is transformed into a system of differential equations that is suitable for solution by means of Numerov method. The obtained solutions are compared with the exact solutions, and are shown to be very effective in solving both initial and boundary value problems in ordinary differential equations.
Main stages of establishment of farms in independent Ukraine
Authors: Dolynska M.
Published: June 2021

Purpose. The aim of the article is to outline the evolution of the formation of farms from peasant (farmer) farms to family farms during 1991-2021 in independent Ukraine; to distinguish separate stages of development of various agricultural formations, which were called "farms" in independent Ukraine. Methodology. The methodology covers a comprehensive analysis and generalization of available scientific and theoretical material and the formation of relevant conclusions and recommendations. The following methods of scientific cognition were used during the research: comparative-legal, logical-semantic, functional, system-structural, and logical-normative. Results. In the course of the research, the historical and legal analysis of the legal status of the most common types of agribusiness entities such as peasant farms, family farms of independent Ukraine is carried out. Scientific novelty. Having analyzed the development of farming in Ukraine during 1991-2021, five main stages of the development of farming in independent Ukraine are determined. The author states that the main types of farms in Ukraine since 2017 are: a farm-legal entity and a farm without the status of a legal entity, which is registered as a natural person-entrepreneur. Members of one family who have established a farm in the form of a family farm based on registration of a natural person-entrepreneur are co-entrepreneurs of the above-mentioned family farm.Practical significance. The results of the research can be used in lawmaking and law enforcement during the preparation of normative and legislative acts on the legal regulation of farming.
Legal status of WUNR state authorities
Authors: Lutskyi Myroslav
Published: June 2021

Purpose. The purpose of the study is a comprehensive study of public authorities of the Western Ukraine, their legal status and legal basis. Methods. The methodological basis of the study was a set of general scientific, special scientific and historical methods, as well as the principles of historicism and objectivity. The key was the method of historical retrospective, which allowed to determine the features and legal basis for the formation of public authorities of the Western Ukrainian People's Republic. Results. It is established that the government of the Western Ukrainian People's Republic has carried out a large amount of work to create its own system of state bodies. The convening of the Constituent Assembly and the Ukrainian National Council began with the organizational design. The legal basis for the activities of public authorities in the early stages of Western Ukraine was the legal framework of the Austro-Hungarian monarchy, which was later amended and supplemented by a number of regulations, decrees, orders of the Ukrainian National Council, the State Secretariat. Own legislative and executive bodies were created, as well as the judiciary was reformed. Given the lack of time and circumstances of the Polish-Ukrainian war, it was decided to accept Austrian law, as well as to leave the positions of civil servants and judges who agreed to work for the Western Ukraine. This gives grounds to say that at the legislative level the government of the Western Ukrainian People's Republic has coped with the task of creating its own system of public authorities, although in practical terms, it has been implemented only partially. Scientific novelty. The analysis of legal bases of the organization and competence of public authorities of the Western Ukrainian People's Republic is given. Practical significance. The results of the study can be used in further historical and legal research, preparation of special courses.
Prospects of legal regulation of simplified proceedings in administrative cases
Authors: Khomyshyn Iryna
Published: June 2021

Purpose. The purpose of the study is to analyze the prospects for the legal regulation of simplified proceedings in administrative cases by the Code of Administrative Procedure of Ukraine. Method. The research is based on the complex analysis and generalization of the available practical, scientific and theoretical material and the formation of the corresponding conclusions and offers. The following methods of scientific cognition were used in the research: the dialectical, system-structural, terminological, system-functional, historical, normative-dogmatic, way of generalization. Results. The study examines the historical aspect of the development of legislation on simplified proceedings, including administrative cases. It is established that a particular category of cases can be considered in the framework of simplified proceedings without an oral hearing by examining the evidence provided in writing. Simplified proceedings are differentiated proceedings containing several exceptions to the administrative, procedural form. Simplified proceedings in administrative cases are distinguished not depending on the special categories of administrative matters but particular circumstances and applying a simpler trial procedure in the cases specified by law. The current legislation on applying the rules on the simplified system of justice requires improvement to ensure the effective implementation of procedural guarantees of participants, compliance with the principles of legality and fairness in the consideration and resolution of administrative cases. Scientific novelty. It is established that the formation of simplified proceedings aims to ensure the effective implementation of procedural guarantees of the participants, compliance with the principles of legality and fairness in the consideration and resolution of administrative cases. The practical significance lies in the possibility of using materials in legislative activity, in judicial practice, in the educational process in the study of administrative proceedings.
Соціальне функціонування особистості в умовах сучасного соціуму
Authors: Спицька Ліана , Турбан Вікторія , Завацька Наталія
Published: June 2021

В статті визначено особливості соціального функціонування особистості в умовах сучасного соціуму. Розкрито основні складові ефективності реалізації соціально-психологічної системи корекції афективних розладів особистості зрілого віку в кризові періоди життя. Показано, що застосування принципів системно-синергетичної методології та фрактальні модульні компоненти моделі афективних розладів особистості зрілого віку в кризові періоди життя надають підстави стверджувати, що траєкторія розвитку у точках біфуркації може змінитися за рахунок оптимізації адаптаційного потенціалу, активізації компенсаторних і захисних механізмів, розширення соціально-психологічної компетентності шляхом рефлексивного опанування досвіду, знань, оволодіння навичками стресостійкості і самоконтролю щодо власної поведінки. Це узагальнення дозволило окреслити можливості підвищення ефективності соціально-психологічної допомоги при афективних розладах у осіб зрілого віку в кризові періоди життя завдяки визначенню особливостей субʼєктивних дискурсів, як внутрішніх складових, що зумовлюють розлади афективного спектру, та є мішенями терапії; організації психопрофілактичної й психокорекційної роботи, зокрема на фазах латентного та ініціального фракталів з урахуванням соціально-психологічних чинників афективних розладів особистості зрілого віку на макро-, мезо- та мікрорівнях; використання всіх наявних у розпорядженні психологів, медичної служби, соціальних працівників, духовного наставництва засобів допомоги та превенції при розладах афективного спектру та забезпечення діяльності багатопрофільних бригад фахівців; створення й впровадження диференційованих соціально-психологічних програм корекції розладів афективного спектру відповідно до їх різновидів у осіб зрілого віку в кризові періоди життя.
Ключові слова: особистість, соціальне функціонування, сучасний соціум.
Психологічні особливості кризи духовного розвитку в юнацькому віці
Authors: Мельничук Ірина , Близнюкова Олена
Published: June 2021

У статті проаналізовано наукові підходи до проблеми духовної кризи особистості, основні ознаки та причини її виникнення, особливості прояву в юнацькому віці. Духовна криза розглядається як стан переживання втрати буттєвої основи існування, який виникає у відповідь на емоційну реакцію щодо індивідуально-значущої події або явища і супроводжується процесом пошуку сакрального. Генеза духовної сфери та виникнення криз духовного розвитку в юнацькому віці пов'язані з формуванням світогляду, внутрішньої позиції, моральної свідомості та самосвідомості.
В емпіричному дослідженні використано методику «Діагностика духовної кризи» Л. Шутової та А. Ляшук, за допомогою якої студенти Центральноукраїнського педагогічного університету імені Володимира Винниченка визначили свій стан за категоріями: страждання, переживання відсутності свободи, страх смерті, самотність, безглуздість, відчуття гріховності, відповідальність, незадоволеність у минулому, теперішньому та майбутньому часі.
Аналіз результатів засвідчив про домінування середнього рівня ймовірності виникнення духовної кризи та показників «напруженості екзистенційного вакууму». У часовому вимірі найбільш поширеним виявився регресивний та прогресивний тип духовної кризи. Піковий та низинний тип духовної кризи було діагностовано в 7,7% студентів, які потребували невідкладної психологічної допомоги.
Розуміння проблематики психологічної допомоги охоплює весь спектр емоційного-смислового життя особистості. Узагальнено наукові підходи і визначено напрямки психологічної допомоги в руслі духовноорієнтованого підходув юнацькому віці.
Ключові слова: духовність, духовна криза, екзистенційна криза, сенс життя, духовний розвиток, психологічне консультування у контексті духовноорієнтованого підходу.
SUBJECT DIDACTICS: RELEVANT ISSUES
Authors: Kubiatko Milan
Published: June 2021

I would like to thank the editor of the journal for the space to write some words about actual problems of subject didactic. I would like to ask all readers to remember, this is not a classic scientific text, it is only short reflection for the actual situation in subject didactic as it is perceived by the author of this text.
Current subject or disciplinary didactic is a dynamic discipline, which is still changing and is reporting to actual trends in the relative disciplines like pedagogy, psychology, sociology, philosophy, and others, and also the newest findings from the scientific disciplines, which are connected with subject didactic. The didactic is perceived in different ways by different countries. For example, in the Middle Europe and former post-communist countries it is possible to observe subject didactic, where every subject, has got its own didactic (e.g., didactic of biology, didactic of history, …). For Anglo-Saxon countries it is typical disciplinary didactic (e.g., science didactic). It can cause a little bit problematic view, but the nature of concept is similar. In this text it is used the term “subject didactic”.
EMERGING EDUCATIONAL DESIGN IN ONLINE TRAINING IN HIGHER EDUCATION
Authors: Fernández-Sánchez María Rosa , Silva-Quiroz Juan
Published: June 2021

Universities are living in a time of major transitions regarding the challenge of rethinking and transforming the current pedagogical models so they can respond to the needs of the global knowmad society. In this study, the Design-Based Research (DBR) approach is used to address the improvements of two emerging pedagogical designs in e-learning in the university context: the model of the Center for Research in Education and ICT (CIIET) of the University of Santiago de Chile (Chile) and the model developed by the Education Node research group of University of Extremadura (Spain). The main focus of these models is the student, who by developing activities based on the resolution of a contextualized problem and using new strategies, accompanied by open resources for resolution, resulting in a learning outcome that can be achieved and measured through assessment. This work aims to advance in identifying of some pedagogical keys for the design of online training scenarios that promote environments of production, research, and open dissemination of best practices, to experience new creative forms and collaborative learning, which have emerged within the hyper connected society and the net-culture. Keywords: instructional design, higher education, open educational resources, research-based design
CORRELATES OF SCIENCE CLASSROOM TEACHING WITH SOUTHEAST ASIAN AND EAST ASIAN EIGHTH GRADERS’ SCIENCE ACHIEVEMENT IN TIMSS 2015
Authors: Lay Yoon Fah , Ng Khar Thoe
Published: June 2021

Trends in International Mathematics and Science Study (TIMSS) is an international comparative study that has been implemented by the International Association for the Evaluation of Educational Achievement (IEA) since 1995. This proposed study is aimed to identify the correlations of science classroom teachings with eighth graders' science achievement in TIMSS among Southeast Asian and East Asian countries. The freely downloadable secondary data were analyzed using IEA's International Database (IDB) Analyzer (version 4.0) for TIMSS, a plug-in for SPSS. TIMSS uses an imputation methodology, involving plausible values, to report student performance. This study found that countries with higher average science achievement allocated higher percentage of educational hours for science teaching, students were taught the TIMSS science topics, students attended schools with science laboratories and have assistance available when conducting experiments, computer availability during science lessons, with science teachings were not limited by student needs, and less frequency of student absences. Based on the research findings, policy recommendations were made to the Malaysian Ministry of Education to boost Malaysian eighth graders' science performance in the forthcoming TIMSS assessments.
Keywords: TIMSS, comparative study, classroom teachings, science achievement
FACTORS CONTRIBUTING TO POOR LEARNER PERFORMANCE IN MATHEMATICS: A CASE OF SELECTED SCHOOLS IN MPUMALANGA PROVINCE, SOUTH AFRICA
Authors: Mabena Nomsa , Mokgosi Patricia Namayammu , Ramapela Selina Serole
Published: June 2021

Learners’ mathematics performance globally and locally has been a major concern. Learners are generally not performing well in mathematics. This is also true of learners in Kwagga West Circuit, Nkangala district in Mpumalanga province of South Africa. Performing badly in the subject negatively affects them, preventing them from progressing to the next grades. This research employed a qualitative case study design with observation and semi-structured interviews with a sample of three school management team (SMT) members, six teachers, nine learners, and three parent component members of the school governing body (SGB) to determine factors affecting learner performance in mathematics in the senior phase. The results showed that numerous factors influenced learners’ confidence and performance. The factors found to have an impact on mathematics performance were learner related, such as ill-discipline, language barriers and learner attitudes. Teachers’ factors included lack of pedagogical content knowledge and skill, and lack of appropriate professional training. Finally, the study offers suggestions for further research and recommendations regarding learners, teachers, schools, school management teams, the parents, as well as for the national education ministry.
Keywords: poor performance, senior phase, qualitative research, case study design
EVALUATING DISTANCE EDUCATION IN SERBIA DURING THE COVID-19 PANDEMIC
Authors: Marković Krstić Suzana V. , Milošević Radulović Lela R.
Published: June 2021

Education is a significant factor which contributes to overcoming social, economic, health, ecological and other challenges. During a pandemic, formal education adapts to ongoing circumstances, and the learning-teaching process transitions to distance education. A study of the advantages and disadvantages of the realization of certain modalities of distance education is significant as it contributes to the improvement of its quality. The aim was to determine how the citizens of Serbia evaluated the quality of distance education during the COVID-19 pandemic. The research questions focused on how they evaluated: distance education based on modality (via Radio Television of Serbia, Google Classroom, Google Meet, Zoom, Viber groups, WhatsApp), the level of involvement of the learners/students during distance learning classes, the quality and extent of their acquired knowledge, and the level of skills that teachers need to effectively teach in distance education. The study presents the results of a survey carried out in 2020 on a sample of 602 adult Serbian citizens. The results confirm the initial hypothesis that certain modalities of distance education received a highly positive evaluation (Google Classroom, Google Meet, Zoom), and that teachers, learners/students, and other citizens provided statistically significant different evaluations of their quality (classes for primary and secondary school students broadcast on the Radio Television of Serbia; classes via Viber groups, on WhatsApp). Citizens feel that distance education enables efficient learning-teaching during the pandemic, confirming the importance of modern technologies for the learning-teaching process in Serbia, and the need for their continued intense development and application in education.
Keywords: learners/students, distance education, Serbia, teachers’ skills, the COVID-19 pandemic
ACHIEVING ACTIVE LEARNING AND DEEP LEARNING WITH MEDIA USING THE EXAMPLE OF TEACHING FINANCE
Authors: Zureck Alexander
Published: June 2021

The range of study programs in finance and the ways how to study due to place, time, and focus has increased in recent years. Students can choose what and how they want to learn. If someone finds an appropriate program he must decide to study face-to-face, online, or in a hybrid format. Finance is often a duty in business administration or related study programs. For many students in those classes the financial topics are bleak. This leads to a passive consumption of contents and ends often in dropping out. The aim of this research was to discuss methods to activate and keep learners motivated by using well selected media in teaching. To identify which media is used in teaching, a literature review was done. Teaching annual reports and other official reports available in English and/or German from several international educational institutions are read, compared, and analyzed. Additionally, secondary academic literature is checked for further examples. In a first step, therefore, different techniques to active students, such as collaboration or interaction, are discussed critically on a literature base. In a second step, based on the techniques, a selection matrix was obtained that supports educators to select the right medium to deal with a certain technique. Many examples were found that might assist educators in the practical use of the selection matrix. Keywords: active learning in finance, motivation in higher education, media selection
Methodological bases of priority directions of scientific researches in the agrarian sector of Ukraine
Authors: Danylenko A. , Varchenko O.M. , Krusanov D.
Published: June 2021

The article systematizes the methodological principles and highlights the priority areas of research in the agricultural sector of the economy, taking into account the factors of external and internal environment of its development. The key challenges facing the world and national agricultural sphere are analyzed and systematized, among which the starvation of a large part of the world's population and its poverty, which are also inherent in Ukraine, are considered in detail. It is emphasized that the common challenges of food security in the world and in individual countries imply differences in approaches to their solution. It is proved that solving problems and overcoming challenges is mediated through transformations and changes that have taken place and will continue to take place in the agricultural sector of Ukraine. The main ones are: global climate change, the COVID-2019 pandemic, elections to local governments, regional councils and councils of enlarged districts and local councils of united territorial communities, the opening of the land market, etc. The priority directions of scientific researches in the agrarian sector of economy are substantiated, which are first of all connected with the following tasks: food security, increase of stability in the conditions of development turbulence, maintenance of innovative and sustainable development, increase of competitiveness of agro-food chains, sustainable development of united territorial communities. agricultural production, improving the quality of the rural population life and others. It is established that modern science has formed a powerful methodological and methodological potential, which allows to successfully solve the problem of creating models to support decision-making on the strategic development of any economic system, including agricultural sector of the economy. It is argued that rational scenarios for the long-term development of the agricultural sector can be obtained only on the basis of a reasonable combination of different methodological approaches, models and methods of research in the agricultural sector. The main models of support and decision-making for the strategic development of the agricultural sector as a socio-economic system are identified: data analysis methods (Data Mining), scenario method, simulation models, Monte Carlo method, data mining methods, methods of intellectual and cognitive modeling.
Keywords: agricultural sector, methodology, priority scientific researches, territorial communities, agriculture, food industry.
TRANSFER LEARNING ON DEEP NEURAL NETWORK: A CASE STUDY ON FOOD-101 FOOD CLASSIFIER
Authors: Tripathi Prakhar
Published: June 2021

—In the era of the ‘Big-Data’ we hear a lot
about machine learning for working on this big data.
Machine learning helps us to predict and analyze data
with better accuracy and least human intervention.
Machine learning is autonomous but susceptible to
errors. This is due to biased prediction when previously
trained on small data. This leads to chain of errors that
can`t be determined easily for long period of time. And
when recognized takes lot time to recognize source.
There comes the idea of deep learning which achieves
the flexibility by using use nested hierarchy of concept to
define the world. But deep learning has setback of taking
very long time to train data which could be reduced by
using transfer learning.
DESIGN, PERFORMANCE ANALYSIS OF WING, AND MANUFACTURING OF FIXED WING HAND LAUNCH UNMANNED AERIAL VEHICLE
Authors: Das Patel Krishn , Kumar Karuparthi Bala Syam
Published: June 2021

This paper concentrates on the design, analysis,
and development of fixed-wing hand launch unmanned
aerial vehicle (UAV). This flight can able to carry the
payloads of 0.8. The design process involves the
conceptual, preliminary, and detailed design. This paper
involves the investigation of the aerodynamic
characteristics over the wing to enhance the aerodynamic
design of the UAV. This analysis includes estimating the
best gliding ratio to increase the flight mission and attain
the maximum altitude. This simulation will be performed
for subsonic flow with Mach number 0.04202(14.3m/s).
The manufacturing of the UAV is done using composite
materials like glass fiber of both (1mm and 2 mm)
thickness, carbon fiber of 2mm, and carbon rod is used for
connecting the empennage to the fuselage. The detailed
design has been done in CATIA V5 and the analysis of the
wing has been done using XFLR, ANSYS (fluent).
COMPREHENSIVE STUDY OF SILVER NANOPARTICLES OBTAINED FROM PINUS ROXBURGHII OBTAINED BY GREEN SYNTHESIS CHARACTERIZATION AND ANTIMICROBIAL APPLICATIONS.
Authors: Gajanan Pawar Minakshi , M. Mulani Ramjan
Published: June 2021

The increasing resistance of microorganisms
against antibiotics threatens the microbiologist.
Quantum dots are found to be an excellent antibacterial
agent against P. aeruginosa. In the present study pinus
roxburghii collected from the Mahabaleshwar region of
Maharashtra, India.
The plants have been washed and dried in the
shade for 10- 15 days. The 5 gm dried plant powder was
boiled in 100ml of double distilled water, whose extract
is used for, The titration of 1mmol silver nitrate solution.
The change in color from pale yellow to red wine and,
optical absorption peak in UV studies at 420 nm
confirms existence of quantum dots. The morphology of
the nanoparticles studied by FE-SEM analysis reveals,
the particle size of 100 ± 40 nm. A good antimicrobial
activity of obtained quantum dots, againstp. aeruginosa
is evidenced with 17 mm in diameter a zone of inhibition.
As p aeruginosa causes infection in wounds burns this
study has recommended the use of quantum dots in
ointments, lotions, and skin creams for early and safe recovery.
ASSESSMENT OF THE AWARENESS AND SAFETY PRACTICES IN MITIGATING HAZARDS OF SILICA DUST EXPOSURE AMONG CONSTRUCTION WORKERS
Authors: E. Saong Engr. Jeferd , L. Babaran Abigail , Dale A. Balaho Glenn
Published: June 2021

Construction sites generate high
levels of dust typically from concrete, silica,
asbestos, cement, wood, stone, and sand.
Workers who are exposed to the said
environment are faced with the risk of inhaling
particulate materials that might lead to
adverse respiratory problems. The lack of
publication on the awareness of construction
workers on the risk associated with silica dust
exposure was the basis of the study. This study
assessed the level of awareness of construction
workers on the risk associated with silica dust
exposure and the safety practices to minimize
it. Purposive sampling was used in the selection
of 65 respondents from different construction
sites located in Baguio City, Philippines. A
survey questionnaire containing four point
Likert scales were used to determine the level
of awareness on the health effects, mode of
transmission, and sources of silica dust. The
study further assessed the level of safety
practices in mitigating the effects of silica dust
exposure. The respondents were moderately
aware (M=2.52) of the health effects,
moderately aware (M=2.69) of the mode of
transmission, and moderately aware (M=3.08)
of the sources of silica dust. The results further
showed that the respondents moderately
practiced (M=2.84) activities to mitigate the
health effects of silica dust exposure and
moderately practiced (M=3.17) the use of
personal protective equipment in the
construction site. The results suggest that
construction workers must be made more
aware of the health effects of silica dust
exposure and, mitigation activities and
utilization of personal protective equipment
must be strictly imposed in the construction
site.
MATHEMATICAL ANALYSIS OF THE ENDEMIC EQUILIBRIUM OF MALARIAHYGIENE MODEL
Authors: Temidayo J. Oluwafemi , E. Azuaba , N. O. Lasisi
Published: June 2021

In this study, we analyzed the endemic
equilibrium point of a malaria-hygiene mathematical
model. We prove that the mathematical model is
biological and meaningfully well-posed. We also
compute the basic reproduction number using the next
generation method. Stability analysis of the endemic
equilibrium point show that the point is locally stable
if reproduction number is greater that unity and
globally stable by the Lasalle’s invariant principle.
Numerical simulation to show the dynamics of the
compartment at various hygiene rate was carried out.
LABORATORY STUDY ON SELF HEALING CONCRETE PAVEMENT – REVIEW PAPER
Authors: K Prerana , G Rajrajeswari , B R Ranjitha , Vidyashree S K , J Ranjitha
Published: June 2021

Concrete could be a variable material having
several blessings. thus it's the foremost wide used material
within the housing industry. several researchers created
makes an attempt to use waste materials with the target of
eliminating the disposal issues and at constant time up the
properties of concrete.
Self-healing concrete is that the want of the hour within
the current state of affairs. Deterioration is inevitable
though innovations square measure streaming within the
field of concrete technology. Admixtures return handy in
economy purpose of read for achieving self healing in
concrete structures thus on scale back the cracks within
the earlier stage itself.
Self-healing technology could be a new field at intervals
material technology. It represents a revolution in
materials engineering and is dynamical the means that
materials behave. Incorporating self healing technology
into the road style method has the potential to rework
building and maintenance processes by increasing the
period of time of roads and eliminating the necessity for
road maintenance.
PARAMETRIC STUDY OF CABLE STAYED BRIDGE USING DIFFERENT PYLON CONFIGUARTION
Authors: Shah Neel , Kanzariya Prashant , Shah Dr. Bimal
Published: June 2021

Cable stayed bridge are the most
flexible bridge and getting popularity because of
its economy for longer spans. Cable stayed
bridges have good stability, optimum use of
structural materials, aesthetic, low design and
maintenance costs, and efficient structural
characteristics. Therefore, this type of bridges
are given preference for long span crossings
compared to suspension bridges. A study is
carried out to find the dynamic effect on
different configuration of pylons of a cable
stayed bridge. A pylon is inclined at 5o , 10o
, 15o
,
20o
, 25o
and 30o with vertical and horizontal axis
both and compared with vertical pylon to study
the dynamic response of bridge. The 3D bridge
models are prepared on CSI BRIDGE software
and bridge is analyzed seismically by Imperial
Valley 1947, Earthquake. The bridge response
in terms of Pylon, Girder and Cable axial force,
moment and torsion is obtained. The study
reveals that the different angle of the pylon has
great influence in the seismic response of cable
stayed bridge. We are getting minimum axial
force at 10o
in cable at main span, girder at
main span and pylon.
The Role of Active Teaching Methods in the Formation of Students’ Cognition and Creativity
Authors: Babaev D. , Bylykova M.
Published: June 2021

Higher education as a subject of study of this article in the summer provides for the process of teaching pedagogical disciplines. When conducting seminars in a higher educational institution, the cognitive activity and creativity of students of individual methods of developing physical activity for the purpose of research. Recognition of students and creative activity of children. conversation “brainstorming”, “game activities” “round table” competition of practical works and methods of their discussion is used. It recognizes students on the basis of methods, determining the conditions for the development of culture and creativity. Specific recommendations are given. Student creativity the fact that active learning has a great influence on improvement, also identified. Results in higher educational institution to improve the process of teaching pedagogical disciplines contributes to. This article is recommended for university professors for use in seminars.
New Book Format of the XXI Century - Electronic Textbooks
Authors: Babayeva Z.
Published: June 2021

The rapid informatization process of the education system has created both the opportunities and the need for the use of e-books in education. E-books allow students to actively participate in the learning process, to personalize their learning, to gain new knowledge and to evaluate their own abilities. The e-textbook also enriches traditional forms of learning, encompassing a large amount of teaching and learning materials and stimulating the development of new teaching methods. In our opinion, it is time to switch to electronic and interactive formats in the development of electronic aids and textbooks in universities. One of the leading directions in the use of information and communication technologies today is the effective use of computers in educational activities. The main issue in implementing this activity is the selection of e-learning resources that will improve the quality of education.
Value Added Intellectual Capital Memoderasi Pengaruh, Leverage, Risiko Sitematis, Growth Opportunities, dan Firm SizeTerhadap Earning Response Coefficient (ERC)
Authors: Gunawan Ari , Anwar Choirul , Djaddang Syahril
Published: June 2021

Objective of this research is to test value added intellectual capital to moderate influence, leverage, systematic risk, growth opportunities and firm size against earnings response coefficient (ERC). This research was conducted on listed automotive companies on the BEI in the period 2013-2017 with purposive sampling technique. The number of samples we obtained is 58 companies. Data analysis technique that we used in this research is Structure Equation Modeling technique WarpPLS 6.0. Results of hypothesis testing by using Structure Equation Modeling technique SEM-PLS, is that: Leverage does not affect the ERC, the results of this study is in line with managerial perspective (Trade Off Theory). Systematic risk have negative affect with the ERC, the results of this study is in line with the risk motive. Growth Opportunities positively affect the ERC, The results of this study is in line with positive accounting theory. Firm Size does not affect the ERC, it means the company is not able to take advantage of owned assets to create company profitability. VAIC does not moderate the relationship between Leverage, Systematic Risk, Growth Opportunities, Firm Size against ERC. Value Added Intelectual capital has a high subjectivity because VAIC measurements can not be done properly against corporate IC, because there is no appropriate measuring tool to calculate the company IC.

Abstrak

Studi ini bertujuan untuk melakukan pengujian value added intellectual capital memoderasi pengaruh,leverage, risiko sistematis, growthopportunities dan firm size terhadap earning responsecoefficient (ERC). Penelitian ini dilakukan pada perusahaaan otomotif yang terdaftar di BEI pada periode 2013-2017 dengan teknik purposive sampling diperoleh jumlah sampel sebanyak 58 perusahaan. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik Struktur Equation Modeling WarpPLS 6.0. . Dari hasil pengujian hipotesis dengan mengunakan teknik Struktur Equation Modeling SEM-PLS, dapat disimpulkan bahwa : Leverage  tidak berpengaruh terhadap ERC, hasil penelitian ini searah dengan prespektif manajerial (Teori Trade Off). Resiko sistematis berpengaruh negatif terhadap ERC, hasil penelitian ini ini searah dengan motif risiko.Growth Opportunities berpengaruh positif terhadap ERC, Hasil penelitian ini searah dengan teori akuntnasi positif.Firm Sizetidak berpengarug terhadap ERCartinya perusahaan tidak mampu memanfaatkan aset yang dimiliki untuk menciptakan profitabilitas perusahaan.VAIC tidak memoderasi hubungan antara Leverage,Resiko sistematis, Growth Opportunities,Firm Size terhadap ERC. Value Added Intelectual capital  memiliki subyektifitas yang tinggi karena pengukuran VAIC belum dapat dilakukan dengan tepat terhadap IC perusahaan, karena belum ada alat ukur yang tepat untuk menghitung IC perusahaan.      

KataKunci:Earning Response Coefficient, Leverage,Resiko sistematis, Growth Opportunities

Firm Size, VAIC
Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments
Authors: Zakzuk Josefina , Lozano Ana , Caraballo Luis
Published: June 2021

Glutathione-S transferases (GSTs) are part of a ubiquitous family of dimeric proteins that participate in detoxification reactions. It has been demonstrated that various GSTs induce allergic reactions in humans: those originating from house dust mites (HDM), cockroaches, and helminths being the best characterized. Evaluation of their allergenic activity suggests that they have a clinical impact. GST allergens belong to different classes: mu (Blo t 8, Der p 8, Der f 8, and Tyr p 8), sigma (Bla g 5 and Asc s 13), or delta (Per a 5). Also, IgE-binding molecules belonging to the pi-class have been discovered in helminths, but they are not officially recognized as allergens. In this review, we describe some aspects of the biology of GST, analyze their allergenic activity, and explore the structural aspects and clinical impact of their cross-reactivity.
Molecular Mechanisms of Nanomaterial-Bacterial Interactions Revealed by Omics—The Role of Nanomaterial Effect Level
Authors: Mortimer Monika , Wang Ying , Holden Patricia A.
Published: June 2021

Nanotechnology is employed across a wide range of antibacterial applications in clinical settings, food, pharmaceutical and textile industries, water treatment and consumer goods. Depending on type and concentration, engineered nanomaterials (ENMs) can also benefit bacteria in myriad contexts including within the human body, in biotechnology, environmental bioremediation, wastewater treatment, and agriculture. However, to realize the full potential of nanotechnology across broad applications, it is necessary to understand conditions and mechanisms of detrimental or beneficial effects of ENMs to bacteria. To study ENM effects, bacterial population growth or viability are commonly assessed. However, such endpoints alone may be insufficiently sensitive to fully probe ENM effects on bacterial physiology. To reveal more thoroughly how bacteria respond to ENMs, molecular-level omics methods such as transcriptomics, proteomics, and metabolomics are required. Because omics methods are increasingly utilized, a body of literature exists from which to synthesize state-of-the-art knowledge. Here we review relevant literature regarding ENM impacts on bacterial cellular pathways obtained by transcriptomic, proteomic, and metabolomic analyses across three growth and viability effect levels: inhibitory, sub-inhibitory or stimulatory. As indicated by our analysis, a wider range of pathways are affected in bacteria at sub-inhibitory vs. inhibitory ENM effect levels, underscoring the importance of ENM exposure concentration in elucidating ENM mechanisms of action and interpreting omics results. In addition, challenges and future research directions of applying omics approaches in studying bacterial-ENM interactions are discussed.
Effects of the Haemodynamic Stimulus on the Location of Carotid Plaques Based on a Patient-Specific Mechanobiological Plaque Atheroma Formation Model
Authors: Hernández-López Patricia , Cilla Myriam , Martínez Miguel , Peña Estefanía
Published: June 2021

In this work, we propose a mechanobiological atheroma growth model modulated by a new haemodynamic stimulus. To test this model, we analyse the development of atheroma plaques in patient-specific bifurcations of carotid arteries for a total time of 30 years. In particular, eight geometries (left or right carotid arteries) were segmented from clinical images and compared with the solutions obtained computationally to validate the model. The influence of some haemodynamical stimuli on the location and size of plaques is also studied. Plaques predicted by the mechanobiological models using the time average wall shear stress (TAWSS), the oscillatory shear index (OSI) and a new index proposed in this work are compared. The new index predicts the shape index of the endothelial cells as a combination of TAWSS and OSI values and was fitted using data from the literature. The mechanobiological model represents an evolution of the one previously proposed by the authors. This model uses Navier-Stokes equations to simulate blood flow along the lumen in the transient mode. It also employs Darcy's law and Kedem-Katchalsky equations for plasma and substance flow across the endothelium using the three-pore model. The mass balances of all the substances that have been considered in the model are implemented by convection-diffusion-reaction equations, and finally the growth of the plaques has been computed. The results show that by using the new mechanical stimulus proposed in this study, prediction of plaques is, in most cases, better than only using TAWSS or OSI with a minimal and maximal errors on stenosis ratio of 2.77 and 32.89 %, respectively. However, there are a few geometries in which haemodynamics cannot predict the location of plaques, and other biological or genetic factors would be more relevant than haemodynamics. In particular, the model predicts correctly eleven of the fourteen plaques presented in all the geometries considered. Additionally, a healthy geometry has been computed to check that plaque is not developed with the model in this case.
De novo Design of G Protein-Coupled Receptor 40 Peptide Agonists for Type 2 Diabetes Mellitus Based on Artificial Intelligence and Site-Directed Mutagenesis
Authors: Chen Xu , Chen Zhidong , Xu Daiyun , Lyu Yonghui , Li Yongxiao , Li Shengbin , Wang Junqing , Wang Zhe
Published: June 2021

G protein-coupled receptor 40 (GPR40), one of the G protein-coupled receptors that are available to sense glucose metabolism, is an attractive target for the treatment of type 2 diabetes mellitus (T2DM). Despite many efforts having been made to discover small-molecule agonists, there is limited research focus on developing peptides acting as GPR40 agonists to treat T2DM. Here, we propose a novel strategy for peptide design to generate and determine potential peptide agonists against GPR40 efficiently. A molecular fingerprint similarity (MFS) model combined with a deep neural network (DNN) and convolutional neural network was applied to predict the activity of peptides constructed by unnatural amino acids (UAAs). Site-directed mutagenesis (SDM) further optimized the peptides to form specific favorable interactions, and subsequent flexible docking showed the details of the binding mechanism between peptides and GPR40. Molecular dynamics (MD) simulations further verified the stability of the peptide–protein complex. The R-square of the machine learning model on the training set and the test set reached 0.87 and 0.75, respectively; and the three candidate peptides showed excellent performance. The strategy based on machine learning and SDM successfully searched for an optimal design with desirable activity comparable with the model agonist in phase III clinical trials.
Advanced Modeling and Simulation of Rockfall Attenuator Barriers Via Partitioned DEM-FEM Coupling
Authors: Sautter Klaus Bernd , Hofmann Helene , Wendeler Corinna , Wilson Peter , Bucher Philipp , Bletzinger Kai-Uwe , Wüchner Roland
Published: June 2021

Attenuator barriers, in contrast to conventional safety nets, tend to smoothly guide impacting rocks instead of absorbing large amounts of strain energy arresting them. It has been shown that the rock’s rotation plays an important role in the bearing capacity of these systems. Although experimental tests have to be conducted to gain a detailed insight into the behavior of both the structures and the rock itself, these tests are usually costly, time-consuming, and offer limited generalizability to other structure/environment combinations. Thus, in order to support the engineer’s design decision, reinforce test results and confidently predict barrier performance beyond experimental configurations this work describes an appropriate numerical modeling and simulation method of this coupled problem. For this purpose, the Discrete Element Method (DEM) and the Finite Element Method (FEM) are coupled in an open-source multi-physics code. In order to flexibly model rocks of any shape, sphere clusters are used which employ simple and efficient contact algorithms despite arbitrarily complicated shapes. A general summary of the FEM formulation is presented as well as detailed derivations of finite elements particularly pertinent to rockfall simulations. The presented modeling and coupling method is validated against experimental testing conducted by the company Geobrugg. Good agreement is achieved between the simulated and experimental results, demonstrating the successful practical application of the proposed method.
Construction of Two Alternative Polyadenylation Signatures to Predict the Prognosis of Sarcoma Patients
Authors: Hu Chuan , Liu Chuan , Li Jianyi , Yu Tengbo , Dong Jun , Chen Bo , Du Yukun , Tang Xiaojie , Xi Yongming
Published: June 2021

Background

Increasing evidence indicates that alternative polyadenylation (APA) is associated with the prognosis of cancers.

Methods

We obtained gene expression and APA profiles of 259 sarcoma patients from the TCGA dataportal and TC3A database, respectively. The prognostic signatures, clinical nomograms, and regulatory networks were studied by integrated bioinformatics analyses. Then, the immune cell infiltration profile was obtained from the ImmuCellAI. The association between APA-based signature and immune cells was studied.

Results

A total of 61 and 38 APA events were identified as overall survival (OS)- and progress free-survival (PFS)-related biomarkers, respectively. Two signatures were generated. The area under the curves (AUC) values of OS signature were 0.900, 0.928, and 0.963 over 2-, 4-, and 6-years, respectively. And the AUC values of PFS signature at 2-, 4-, and 6-years were 0.826, 0.840, and 0.847, respectively. Overall and subgroup analyses indicated that high-risk patients had a worse prognosis than low-risk patients (all p-values < 0.05). In addition, immunomics analyses indicated that there are different patterns of immune cell infiltration between low- and high-risk patients. Furthermore, two clinical-APA nomograms were established and the C-indexes were 0.813 and 0.809 for OS nomogram and PFS nomogram, respectively. Finally, two APA regulatory networks were constructed. FIP1L1-VPS26B was identified as a key regulating relationship and validated in the pan-cancer analyses.

Conclusion

In this study, we identified prognostic predictors based on APA events with high accuracy for risk stratification in sarcoma patients and uncovered interesting regulatory networks in sarcoma that could be underlying mechanisms. This study not only provides novel potential prognostic biomarkers but promote precision medicine and provide potential novel research interests for immunotherapy.