bluuebunny/crossref_metadata_2025 huggingface dataset:
Does FDG PET-Based Radiomics Have an Added Value for Prediction of Overall Survival in Non-Small Cell Lung Cancer?
Authors: Ciarmiello Andrea , Giovannini Elisabetta , Tutino Francesca , Yosifov Nikola , Milano Amalia , Florimonte Luigia , Bonatto Elena , Bareggi Claudia , Dellavedova Luca , Castello Angelo , Aschele Carlo , Castellani Massimo , Giovacchini Giampiero
Published: April 2024

Objectives: Radiomics and machine learning are innovative approaches to improve the clinical management of NSCLC. However, there is less information about the additive value of FDG PET-based radiomics compared with clinical and imaging variables. Methods: This retrospective study included 320 NSCLC patients who underwent PET/CT with FDG at initial staging. VOIs were placed on primary tumors only. We included a total of 94 variables, including 87 textural features extracted from PET studies, SUVmax, MTV, TLG, TNM stage, histology, age, and gender. We used the least absolute shrinkage and selection operator (LASSO) regression to select variables with the highest predictive value. Although several radiomics variables are available, the added value of these predictors compared with clinical and imaging variables is still under evaluation. Three hundred and twenty NSCLC patients were included in this retrospective study and underwent 18F-FDG PET/CT at initial staging. In this study, we evaluated 94 variables, including 87 textural features, SUVmax, MTV, TLG, TNM stage, histology, age, and gender. Image-based predictors were extracted from a volume of interest (VOI) positioned on the primary tumor. The least absolute shrinkage and selection operator (LASSO) Cox regression was used to reduce the number of variables and select only those with the highest predictive value. The predictive model implemented with the variables selected using the LASSO analysis was compared with a reference model using only a tumor stage and SUVmax. Results: NGTDM coarseness, SUVmax, and TNM stage survived the LASSO analysis and were used for the radiomic model. The AUCs obtained from the reference and radiomic models were 80.82 (95%CI, 69.01–92.63) and 81.02 (95%CI, 69.07–92.97), respectively (p = 0.98). The median OS in the reference model was 17.0 months in high-risk patients (95%CI, 11–21) and 113 months in low-risk patients (HR 7.47, p < 0.001). In the radiomic model, the median OS was 16.5 months (95%CI, 11–20) and 113 months in high- and low-risk groups, respectively (HR 9.64, p < 0.001). Conclusions: Our results indicate that a radiomic model composed using the tumor stage, SUVmax, and a selected radiomic feature (NGTDM_Coarseness) predicts survival in NSCLC patients similarly to a reference model composed only by the tumor stage and SUVmax. Replication of these preliminary results is necessary.
Reinforcement of a Subcutaneous Pocket for Implantable Cardioverter Defibrillator Insertion Using Acellular Dermal Matrix: A Case Report
Authors: Choi Jun Ho , Lee Ho Jun , Kim Kwang Seog , Park Hyung Wook , Choi Insu , Hwang Jae Ha , Lee Sam Yong
Published: April 2024

Pediatric patients who undergo implant insertion into the chest wall face a high risk of implant exposure to the external environment. Five months after an 8-year-old boy underwent implantable cardioverter–defibrillator (ICD) implantation in a subcutaneous pocket in the left anterolateral chest wall to manage long QT syndrome, ICD replacement became necessary owing to exposure risk from distal and lateral thinning of the ICD pocket. Pocket rupture and exposure would increase the risk of infection; therefore, we performed ICD removal and primary pocket closure. Two weeks later, a new suprafascial pocket was created, an acellular dermal matrix (ADM) was attached to the inner wall to prevent ICD protrusion, and a new ICD was inserted. One year postoperatively, the ADM was engrafted, and no complications were observed. A thin subcutaneous layer increases the risk of ICD implantation complications. Inner wall strengthening with an ADM can help prevent pocket rupture.
Should We Rule out Celiac Disease in Recurrent Headache Disorders? A Review of the Literature
Authors: Perilli Lorenzo , Carbone Samanta , Novelletto Luca Franco , Santangelo Andrea , Curcio Maria Rosaria , Lotti Federica , Grosso Salvatore
Published: April 2024

Recurrent headaches, encompassing migraine and tension-type headaches, represent prevalent conditions affecting individuals across different age groups, exerting a substantial influence on daily functioning and quality of life. Headaches serve as common manifestations of underlying health issues. Among these, celiac disease, an autoimmune disorder activated by gluten consumption, has emerged as a noteworthy concern. Recent research indicates a correlation between celiac disease and heightened susceptibility to headaches, particularly migraines. Celiac disease (CD) is an immune-mediated systemic, widespread disorder presenting a heterogeneous constellation of symptoms with a relatively easy diagnosis and therapy. Among signs and symptoms exhibited in celiac disease patients, headache is one of the most common neurological issues addressed among both adults and children. Headache disorders and CD are highly prevalent in the general population; for this reason, any causal association between these conditions and the role of a gluten-free diet (GFD) has been debated. The aim of this manuscript is to review the current scientific literature regarding the potential association between CD and headaches and the beneficial effects of a GFD. Among the various authors, in our opinion, the current state of the evidence suggests a significant role for the early screening of CD during the initial diagnosis of recurrent headaches, either in adults or children.
The Prevalence of Cancer in Dutch Female Patients with Idiopathic Scoliosis Compared with the General Population
Authors: Heijboer Reinout R. O. , Heemskerk Johan L. , Vorrink Sigrid N. W. , Kempen Diederik H. R.
Published: April 2024

Background and Objectives: Epidemiological studies have demonstrated the potential oncogenic effects of cumulative radiation exposure, particularly during childhood. One group experiencing repeated exposure to radiation at an early age for multiple years is patients treated for idiopathic scoliosis (IS). This study aimed to determine the relationship between childhood radiological exposure and adult cancer prevalence in children treated for IS. Materials and Methods: Data from 337 predominantly female patients treated at our hospital between January 1981 and January 1995 were gathered and compared to the Dutch national cancer rates. The standardized prevalence ratios for cancer in IS patients were compared with the cancer prevalence rates from the general Dutch population. Results: The overall cancer prevalence in women was 5.0%, with no significant difference compared to the general population (p = 0.425). The results of this study do not suggest that female patients treated for idiopathic scoliosis during childhood have an increased risk of cancer later in life. Conclusion: Despite being the largest recent study in its field, the modest participant number limits its ability to draw conclusions. However, the detailed data collected over a long observation period, alongside data from a period with comparable radiation rates, contributes to refining clinical practice and laying the groundwork for future systematic reviews.
Undescended Testes Growth Potential in Relation to Testis Position from Diagnosis until Puberty
Authors: Nowak Maciej , Niedzielski Jerzy , Slowikowska-Hilczer Jolanta , Walczak-Jedrzejowska Renata , Marchlewska Katarzyna
Published: April 2024

Background: Testicular volume (TV) and testicular atrophy index (TAI) were used to determine criteria for normal, hypotrophic and atrophic undescended testes (UDT). Objectives: This study aimed to determine changes in TV and TAI in patients with different types of UDT. Materials and Methods: 182 boys (aged 0.3–14.0 years) with 212 UDTs were assessed twice 24 months apart. Testes were unilateral (UCT) or bilateral canalicular (BCT) and intra-abdominal (IAT). Results: At the beginning of the observation, the highest TAI was observed in IAT and the lowest in the BCT group (38.1 vs. 12.5%, p < 0.05). After 2 years, the highest TAI was observed in the BCT and IAT groups (20.5 and 19.1%), while the lowest was in the UCT group (12.0%, p < 0.05). At the beginning and after 2 years, the highest TAI was observed in boys aged < 6 years (25.0%, 18.2%) and the lowest in pubertal boys aged 12–14 years (5.9%, 7.3%, p < 0.05). A total of 78.3% of patients at the beginning and 86.8% at the end of the observation had TAI < 30%. Furthermore, 7% of boys at the beginning and 3% at the end of the observation had TAI > 50%. IATs have the highest testicular growth potential (TGP), while BCTs have the lowest (120.0 vs. 28.6%, p < 0.05). The highest TGP was in boys aged < 3 years (100%, p < 0.05) and boys aged 12–14 years (98.1%, p < 0.05), while the lowest was in boys aged 9–10.9 years (19.5%, p < 0.05). Conclusions: We revealed the continuous growth of UDTs until puberty independently of their position. IATs revealed high growth potential.
Ultrasonic-Assisted Electrodeposition of Mn-Doped NiCo2O4 for Enhanced Photodegradation of Methyl Red, Hydrogen Production, and Supercapacitor Applications
Authors: Lee Kuan-Ching , Tiong Timm Joyce , Pan Guan-Ting , Yang Thomas Chung-Kuang , Uma Kasimayan , Tseng Zong-Liang , Nikoloski Aleksandar N. , Huang Chao-Ming
Published: April 2024

This paper presents a novel ultrasonic-assisted electrodeposition process of Mn-doped NiCo2O4 onto a commercial nickel foam in a neutral electroplating bath (pH = 7.0) under an ultrasonic power of 1.2 V and 100 W. Different sample properties were studied based on their crystallinity through X-ray diffraction (XRD), morphology was studied through scanning electron microscopy (SEM), and photodegradation was studied through ultraviolet–visible (UV–Vis) spectrophotometry. Based on the XRD results, the dominant crystallite phase obtained was shown to be a pure single NiCo2O4 phase. The optical properties of the photocatalytic film showed a range of energy band gaps between 1.72 and 1.73 eV from the absorption spectrum. The surface hydroxyl groups on the catalytic surface of the Mn-doped NiCo2O4 thin films showed significant improvements in removing methyl red via photodegradation, achieving 88% degradation in 60 min, which was approximately 1.6 times higher than that of pure NiCo2O4 thin films. The maximum hydrogen rate of the composite films under 100 mW/cm2 illumination was 38 μmol/cm2 with a +3.5 V external potential. The electrochemical performance test also showed a high capacity retention rate (96% after 5000 charge–discharge cycles), high capacity (260 Fg−1), and low intrinsic resistance (0.8 Ω). This work concludes that the Mn-doped NiCo2O4 hybrid with oxygen-poor conditions (oxygen vacancies) is a promising composite electrode candidate for methyl red removal, hydrogen evolution, and high-performance hybrid supercapacitor applications.
Editorial for the Special Issue on Multidisciplinary Composites
Authors: Singh Swadesh Kumar , Tummala Suresh Kumar , Kosaraju Satyanarayana , Haider Julfikar
Published: April 2024

The remarkable blend of features that advanced composites can provide, such as high stiffness, good strength-to-weight ratio, good corrosion resistance, design freedom, and product variety, has expanded their applicability [...]
Tailoring Microemulsification Techniques for the Encapsulation of Diverse Cargo: A Systematic Analysis of Poly (Urea-Formaldehyde) Microcapsules
Authors: Rajasekaran Sivashankari P. , Huynh Bao , Fugolin Ana Paula P.
Published: April 2024

Cargo encapsulation through emulsion-based methods has been pondered over the years. Although several microemulsification techniques have been employed for the microcapsule’s synthesis, there are still no clear guidelines regarding the suitability of one technique over the others or the impacts on the morphological and physicochemical stability of the final particles. Therefore, in this systematic study, we investigated the influence of synthesis parameters on the fabrication of emulsion-based microcapsules concerning morphological and physicochemical properties. Using poly(urea-formaldehyde) (PUF) microcapsules as a model system, and after determining the optimal core/shell ratio, we tested three different microemulsification techniques (magnetic stirring, ultrasonication, and mechanical stirring) and two different cargo types (100% TEGDMA (Triethylene glycol dimethacrylate) and 80% TEGDMA + 20% DMAM (N,N-Dimethylacrylamide)). The resulting microcapsules were characterized via optical and scanning electron microscopies, followed by size distribution analysis. The encapsulation efficiency was obtained through the extraction method, and the percentage reaction yield was calculated. Physicochemical properties were assessed by incubating the microcapsules under different osmotic pressures for 1 day and 1, 2, or 4 weeks. The data were analyzed statistically with one-way ANOVA and Tukey’s tests (α = 0.05). Overall, the mechanical stirring resulted in the most homogeneous and stable microcapsules, with an increased reaction yield from 100% to 50% in comparison with ultrasonication and magnetic methods, respectively. The average microcapsule diameter ranged from 5 to 450 µm, with the smallest ones in the ultrasonication and the largest ones in the magnetic stirring groups. The water affinities of the encapsulated cargo influenced the microcapsule formation and stability, with the incorporation of DMAM leading to more homogeneous and stable microcapsules. Environmental osmotic pressure led to cargo loss or the selective swelling of the shells. In summary, this systematic investigation provides insights and highlights commonly overlooked factors that can influence microcapsule fabrication and guide the choice based on a diligent analysis of therapeutic niche requirements.
Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study
Authors: Raszewski Zbigniew , Chojnacka Katarzyna , Mikulewicz Marcin
Published: April 2024

Objective: Dental hypersensitivity remains widespread, underscoring the need for materials that can effectively seal dental tubules. This study evaluated the potential of bioactive-glass-infused hydroxyethyl cellulose gels in this context. Methods: Five gels were synthesized, each containing 20% bioactive glass (specifically, 45S5, S53P4, Biomin F, and Biomin C), with an additional blank gel serving as a control. Subjected to two months of accelerated aging at 37 ± 2 °C, these gels were assessed for key properties: viscosity, water disintegration time, pH level, consistency, adhesion to glass, and element release capability. Results: Across the board, the gels facilitated the release of calcium, phosphate, and silicon ions, raising the pH from 9.00 ± 0.10 to 9.7 ± 0.0—a range conducive to remineralization. Dissolution in water occurred within 30–50 min post-application. Viscosity readings showed variability, with 45S5 reaching 6337 ± 24 mPa/s and Biomin F at 3269 ± 18 mPa/s after two months. Initial adhesion for the blank gel was measured at 0.27 ± 0.04 Pa, increasing to 0.73 ± 0.06 Pa for the others over time. Gels can release elements upon contact with water (Ca− Biomin C 104.8 ± 15.7 mg/L; Na− Biomin F 76.30 ± 11.44 mg/L; P− Biomin C 2.623 ± 0.393 mg/L; Si− 45S5-45.15 ± 6.77mg/L, F− Biomin F− 3.256 ± 0.651mg/L; Cl− Biomin C 135.5 ± 20.3 mg/L after 45 min). Conclusions: These findings highlight the gels’ capacity to kickstart the remineralization process by delivering critical ions needed for enamel layer reconstruction. Further exploration in more dynamic, real-world conditions is recommended to fully ascertain their practical utility.
Multibeam Wideband Transmit Beamforming Using 2D Sparse FIR Trapezoidal Filters
Authors: Dissanayake Nadeeshan , Edussooriya Chamira U. S. , Wijenayake Chamith , Madanayake Arjuna
Published: April 2024

A low-complexity multibeam wideband transmit beamformer using a 2D sparse FIR filter design capable of multiple beams is proposed as a digital building block for fully digital beamformers. The 2D sparse FIR filter has multiple trapezoid-shaped passbands pertaining to wideband beams aimed at particular directions. The proposed multibeam digital beamformer drives a uniform linear array of wideband antenna elements to achieve the wideband multibeam transmit-mode signals desired by the communication system. The 2D sparse FIR filter is designed to be optimal in the minimax sense using convex optimization techniques. Full-wave electromagnetic simulations using real antenna models confirm that the proposed wideband transmit beamformer can achieve multibeam transmission in the 1.3–2.8 GHz frequency range, with more than 70% fractional bandwidth. Furthermore, the adoption of the wideband transmit multibeam beamformer leads to a significant reduction in digital arithmetic (computational) complexity compared with previously reported wideband transmit beamformers of similar transfer function type, without deteriorating beam directionality and causing increases in the side-lobe level. The proposed sparse 2D FIR multibeam beamformer architecture is well-suited for both sub-6 GHz (legacy) band transmit beamforming, frequency range three (FR3) beamforming up to 28 GHz, and mmWave operation for emerging 5G/6G applications.
Analysis and Interpretation of Automated Blood Count in the Treatment of Chronic Paracoccidioidomycosis
Authors: Brito Eliana da Costa Alvarenga de , França Adriana de Oliveira , Siqueira Igor Valadares , Félix Vinícius Lopes Teodoro , Rezende Amanda Alves , Amorim Bárbara Casella , Silva Suzane Eberhart Ribeiro da , Mendes Rinaldo Poncio , Weber Simone Schneider , Paniago Anamaria Mello Miranda
Published: April 2024

Blood count is crucial for assessing bone marrow’s cell production and differentiation during infections, gaging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic forms of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological cells in different stages of the PCM chronic form, we evaluated the blood count, including immature blood cells in automated equipment, before and during the treatment follow-up of 62 chronic PCM patients. Predominantly male (96.8%) with an average age of 54.3 (standard deviation SD 6.9) years, participants exhibited pre-treatment conditions such as anemia (45.2%), monocytosis (38.7%), and leukocytosis (17.7%), which became less frequent after clinical cure. Anemia was more prevalent in severe cases. Notably, hemoglobin and reticulocyte hemoglobin content increased, while leukocytes, monocytes, neutrophils, immature granulocytes, and platelets decreased. Chronic PCM induced manageable hematological abnormalities, mainly in the red blood series. Monocytosis, indicating monocytes’ role in PCM’s immune response, was frequent. Post-treatment, especially after achieving clinical cure, significant improvements were observed in various hematological indices, including immature granulocytes and reticulocyte hemoglobin content, underscoring the impact of infection on these parameters.
An Enzymatic and Proteomic Analysis of Panus lecomtei during Biodegradation of Gossypol in Cottonseed
Authors: Neto Clemente Batista Soares , Gomes Taísa Godoy , Filho Edivaldo Ximenes Ferreira , Fontes Wagner , Ricart Carlos André Ornelas , de Almeida João Ricardo Moreira , de Siqueira Félix Gonçalves , Miller Robert Neil Gerard
Published: April 2024

Cotton is an important plant-based protein. Cottonseed cake, a byproduct of the biodiesel industry, offers potential in animal supplementation, although the presence of the antinutritional sesquiterpenoid gossypol limits utilization. The macrofungus Panus lecomtei offers potential in detoxification of antinutritional factors. Through an enzymatic and proteomic analysis of P. lecomtei strain BRM044603, grown on crushed whole cottonseed contrasting in the presence of free gossypol (FG), this study investigated FG biodegradation over a 15-day cultivation period. Fungal growth reduced FG to levels at 100 μg/g, with a complex adaptive response observed, involving primary metabolism and activation of oxidative enzymes for metabolism of xenobiotics. Increasing activity of secreted laccases correlated with a reduction in FG, with enzyme fractions degrading synthetic gossypol to trace levels. A total of 143 and 49 differentially abundant proteins were observed across the two contrasting growth conditions after 6 and 12 days of cultivation, respectively, revealing a dynamic protein profile during FG degradation, initially related to constitutive metabolism, then later associated with responses to oxidative stress. The findings advance our understanding of the mechanisms involved in gossypol degradation and highlight the potential of P. lecomtei BRM044603 in cotton waste biotreatment, relevant for animal supplementation, sustainable resource utilization, and bioremediation.
Synthesis of Extracellular L-lysine-α-oxidase along with Degrading Enzymes by Trichoderma cf. aureoviride Rifai VKM F-4268D: Role in Biocontrol and Systemic Plant Resistance
Authors: Arinbasarova Anna Yu. , Botin Alexander S. , Medentsev Alexander G. , Makrushin Kirill V. , Vetcher Alexandre A. , Stanishevskiy Yaroslav M.
Published: April 2024

When cultivating on wheat bran or deactivated fungal mycelium as a model of “natural growth”, the ability of Trichoderma to synthesize extracellular L-lysine-α-oxidase (LysO) simultaneously with cell-wall-degrading enzymes (proteases, xylanase, glucanases, chitinases, etc.), responsible for mycoparasitism, was shown. LysO, in turn, causes the formation of H2O2 and pipecolic acid. These compounds are known to be signaling molecules and play an important role in the induction and development of systemic acquired resistance in plants. Antagonistic effects of LysO have been demonstrated against phytopathogenic fungi and Gram-positive or Gram-negative bacteria with dose-dependent cell death. The antimicrobial effect of LysO decreased in the presence of catalase. The generating intracellular ROS in the presence of LysO was also shown in both bacteria and fungi, which led to a decrease in viable cells. These results suggest that the antimicrobial activity of LysO is due to two factors: the formation of exogenous hydrogen peroxide as a product of the enzymatic oxidative deamination of L-lysine and the direct interaction of LysO with the cell wall of the micro-organisms. Thus, LysO on its own enhances the potential of the producer in the environment; namely, the enzyme complements the strategy of the fungus in biocontrol and indirectly participates in inducing SAR and regulating the relationship between pathogens and plants.
Amortizing Loans under Arbitrary Discount Functions
Authors: Mari Carlo
Published: April 2024

A general methodology for loan amortization under arbitrary discount functions is discussed. It is shown that it is always possible to uniquely define a scheme for constructing the loan amortization schedule with an arbitrary assigned discount function. It is also shown that, even if the loan amortization is carried out from the sequence of principal payments and the sequence of accrued interest, the underlying discount function can be uniquely determined at the maturities corresponding to the installment payment dates. As a special case of the proposed approach, we derive the amortization method according to the law of simple interest.
The Environmental and Economic Importance of Mixed and Boundary Friction
Authors: Taylor Robert Ian , Sherrington Ian
Published: April 2024

One route to reducing global CO2 emissions is to improve the energy efficiency of machines. Even small improvements in efficiency can be valuable, especially in cases where an efficiency improvement can be realized over many millions of newly produced machines. For example, conventional passenger car combustion engines are being downsized (and also downspeeded). Increasingly, they are running on lower-viscosity engine lubricants (such as SAE 0W-20 or lower viscosity grades) and often also have stop–start systems fitted (to prevent engine idling when the vehicle is stopped). Some of these changes result in higher levels of mixed and boundary friction, and so accurate estimation of mixed/boundary friction losses is becoming of increased importance, for both estimating friction losses and wear volumes. Traditional approaches to estimating mixed/boundary friction, which employ real area of contact modelling, and assumptions such as the elastic deformation of asperities, are widely used, but recent experimental data suggest that some of these approaches underestimate mixed/boundary friction losses. In this paper, a discussion of the issues involved in reliably estimating mixed/boundary friction losses in machine elements is undertaken, highlighting where the key uncertainties lie. Mixed/boundary lubrication losses in passenger car and heavy-duty internal combustion engines are then estimated and compared with published data, and a detailed description of how friction is related to fuel consumption in these vehicles, on standard fuel economy driving cycles, is given. Knowing the amount of fuel needed to overcome mixed/boundary friction in these vehicles enables reliable estimates to be made of both the financial costs of mixed/boundary lubrication for today’s vehicles and their associated CO2 emissions, and annual estimates are reported to be approximately USD 290 billion with CO2 emissions of 480 million tonnes.
Synergistic Effects of Layered Double Hydroxide and MoS2 on the Performance of Lubricants
Authors: Zhou Weidong , Li Yong , Cheng Shutian , He Yongdi , Song Jinou , Zhang Qiang
Published: April 2024

In this study, layered double hydroxide (LDH) and molybdenum disulfide (MoS2) were used as additives to prepare lubricants. The morphology and particle distribution of the LDH and MoS2 were characterized using a scanning electron microscope and a laser particle size analyzer, respectively. Thermogravimetric analysis was used to compare the performance of the lubricants at high temperature. The extreme pressure and wear resistance performance of the lubricants were tested using a four-ball machine and a fretting-wear machine. Then, the lubricants were applied in a bolt fastener. The loosening torque and surface wear condition at high temperature were compared. By adding LDH and MoS2 to the lubricants, the extreme pressure and wear resistance performance and anti-seize performance at high temperature were improved significantly. The LDH showed better anti-seize performance than the MoS2 because of its strong and stable structure at high temperature. The MoS2 showed better anti-wear performance under a high load because of its soft layered structure. The MoS2 with a larger particle size showed better extreme pressure performance under a high load. The LDH and MoS2 played a synergistic effect under the conditions of high temperature and high load.
Green Measures for a Class of Non-Markov Processes
Authors: Suryawan Herry P. , da Silva José L.
Published: April 2024

In this paper, we investigate the Green measure for a class of non-Gaussian processes in Rd. These measures are associated with the family of generalized grey Brownian motions Bβ,α, 0<β≤1, 0<α≤2. This family includes both fractional Brownian motion, Brownian motion, and other non-Gaussian processes. We show that the perpetual integral exists with probability 1 for dα>2 and 1<α≤2. The Green measure then generalizes those measures of all these classes.
Ensemble Approach Using k-Partitioned Isolation Forests for the Detection of Stock Market Manipulation
Authors: Núñez Delafuente Hugo , Astudillo César A. , Díaz David
Published: April 2024

Stock market manipulation, defined as any attempt to artificially influence stock prices, poses significant challenges by causing financial losses and eroding investor trust. The prevalent reliance on supervised learning models for detecting such manipulations, while showing promise, faces notable hurdles due to the dearth of labeled data and the inability to recognize novel manipulation tactics beyond those explicitly labeled. This study ventures into addressing these gaps by proposing a novel detection framework aimed at identifying suspicious hourly manipulation blocks through an unsupervised learning approach, thereby circumventing the limitations of data labeling and enhancing the adaptability to emerging manipulation strategies. Our methodology involves the innovative creation of features reflecting the behavior of stocks across various time windows followed by the segmentation of the dataset into k subsets. This setup facilitates the identification of potential manipulation instances via a voting ensemble composed of k isolation forest models, which have been chosen for their efficiency in pinpointing anomalies and their linear computational complexity—attributes that are critical for analyzing vast datasets. Evaluated against eight real stocks known to have undergone manipulation, our approach demonstrated a remarkable capability to identify up to 89% of manipulated blocks, thus significantly outperforming previous methods that do not utilize a voting ensemble. This finding not only surpasses the detection rates reported in prior studies but also underscores the enhanced robustness and adaptability of our unsupervised model in uncovering varied manipulation schemes. Through this research, we contribute to the field by offering a scalable and efficient unsupervised learning strategy for stock manipulation detection, thereby marking a substantial advancement over traditional supervised methods and paving the way for more resilient financial markets.
The Approximation Characteristics of Weighted Band-Limited Function Space
Authors: Li Yue , Chen Guanggui , Xu Yanyan , Pan Xiangyu
Published: April 2024

This article primarily investigates the width problem within weighted band-limited function space in a uniform setting. Through an analysis of the properties of s-numbers, we establish a connection between the widths of weighted band-limited function spaces and the s-numbers of infinite-dimensional diagonal operators. Furthermore, employing the discretization method, we estimate the exact asymptotic orders of Kolmogorov n-width and linear n-width in the weighted band-limited function space, which is characterized by the weight ω=ωk=|k|rk∈Z0.
Sideslip Angle Estimation for Distributed Drive Electric Vehicles Based on Robust Unscented Particle Filter
Authors: Hu Jie , Rong Feiyue , Zhang Pei , Yan Fuwu
Published: April 2024

An accurate and reliable sideslip angle is crucial for active safety control systems and advanced driver-assistance systems (ADAS). The direct measurement method of the sideslip angle suffers from challenges of high costs and environmental sensitivity, so sideslip angle estimation has always been a significant research issue. To improve the precision and robustness of sideslip angle estimation for distributed drive electric vehicles (DDEV) in extreme maneuvering scenarios, this paper presents a novel robust unscented particle filter (RUPF) algorithm based on low-cost onboard sensors. Firstly, a nonlinear dynamics model of DDEV is constructed, providing a theoretical foundation for the design of the RUPF algorithm. Then, the RUPF algorithm, which incorporates the unscented Kalman filter (UKF) to update importance density and utilizes systematic random resampling to mitigate particle degradation, is designed for estimation. Eventually, the availability of the proposed RUPF algorithm is validated on the co-simulation platform with non-Gaussian noises. Simulation results demonstrate that RUPF algorithm attains a higher precision and stronger robustness compared with the traditional PF and UKF algorithms.
Optimizing Cryptocurrency Returns: A Quantitative Study on Factor-Based Investing
Authors: Seabe Phumudzo Lloyd , Moutsinga Claude Rodrigue Bambe , Pindza Edson
Published: April 2024

This study explores cryptocurrency investment strategies by adapting the robust framework of factor investing, traditionally applied in equity markets, to the distinctive landscape of cryptocurrency assets. It conducts an in-depth examination of 31 prominent cryptocurrencies from December 2017 to December 2023, employing the Fama–MacBeth regression method and portfolio regressions to assess the predictive capabilities of market, size, value, and momentum factors, adjusted for the unique characteristics of the cryptocurrency market. These characteristics include high volatility and continuous trading, which differ markedly from those of traditional financial markets. To address the challenges posed by the perpetual operation of cryptocurrency trading, this study introduces an innovative rebalancing strategy that involves weekly adjustments to accommodate the market’s constant fluctuations. Additionally, to mitigate issues like autocorrelation and heteroskedasticity in financial time series data, this research applies the Newey–West standard error approach, enhancing the robustness of regression analyses. The empirical results highlight the significant predictive power of momentum and value factors in forecasting cryptocurrency returns, underscoring the importance of tailoring conventional investment frameworks to the cryptocurrency context. This study not only investigates the applicability of factor investing in the rapidly evolving cryptocurrency market, but also enriches the financial literature by demonstrating the effectiveness of combining Fama–MacBeth cross-sectional analysis with portfolio regressions, supported by Newey–West standard errors, in mastering the complexities of digital asset investments.
Practical Security of Continuous Variable Quantum Key Distribution Ascribable to Imperfect Modulator for Fiber Channel
Authors: Xu Shengzhe , Zhou Zicheng , Guo Ying
Published: April 2024

An amplitude modulator plays an essential role in the implementation of continuous-variable quantum key distribution (CVQKD), whereas it may bring about a potential security loophole in the practical system. The high-frequency modulation of the actual transmitter usually results in the high rate of the system. However, an imperfect amplitude modulator (AM) can give birth to a potential information leakage from the modulation of the transmitter. To reveal a potential security loophole from the high-frequency AM embedded in the transmitter, we demonstrate an influence on the practical security of the system in terms of the secret key rate and maximal transmission distance. The results indicate the risk of this security loophole in the imperfect AM-embedded transmitter. Fortunately, the legal participants can trace back the potential information leakage that has been produced from the imperfect transmitter at high frequencies, which can be used for defeating the leakage attack in CVQKD. We find the limitations of the imperfect AM-embedded transmitter of the high-frequency quantum system, and hence, we have to trade off the practical security and the modulation frequency of the AM-embedded transmitter while considering its implementation in a practical environment.
Correction: Dobrovskiy et al. The Transport Properties of Semi-Crystalline Polyetherimide BPDA-P3 in Amorphous and Ordered States: Computer Simulations. Membranes 2022, 12, 856
Authors: Dobrovskiy Alexey Y. , Nazarychev Victor M. , Volgin Igor V. , Lyulin Sergey V.
Published: April 2024

The authors wish to make a change to the published paper [...]
Transmembrane Chemical Absorption Process for Recovering Ammonia as an Organic Fertilizer Using Citric Acid as the Trapping Solution
Authors: Reyes Alva Ricardo , Mohr Marius , Zibek Susanne
Published: April 2024

Membrane contactors are among the available technologies that allow a reduction in the amount of ammoniacal nitrogen released into the environment through a process called transmembrane chemical absorption (TMCA). This process can be operated with different substances acting as trapping solutions; however, strong inorganic acids have been studied the most. The purpose of this study was to demonstrate, at laboratory scale, the performance of citric acid as a capturing solution in TMCA processes for recovering ammonia as an organic fertilizer from anaerobic digestor reject water using membrane contactors in a liquid–liquid configuration and to compare it with the most studied solution, sulfuric acid. The experiments were carried out at 22 °C and 40 °C and with a feed water pH of 10 and 10.5. When the system was operated at pH 10, the rates of recovered ammonia from the feed solution obtained with citric acid were 10.7–16.5 percentage points (pp) lower compared to sulfuric acid, and at pH 10.5, the difference decreased to 5–10 pp. Under all tested conditions, the water vapor transport in the system was lower when using citric acid as the trapping solution, and at pH 10 and 40 °C, it was 5.7 times lower. When estimating the operational costs for scaling up the system, citric acid appears to be a better option than sulfuric acid as a trapping solution, but in both cases, the process was not profitable under the studied conditions.
Harnessing Metabolites as Serum Biomarkers for Liver Graft Pathology Prediction Using Machine Learning
Authors: Baciu Cristina , Ghosh Soumita , Naimimohasses Sara , Rahmani Arya , Pasini Elisa , Naghibzadeh Maryam , Azhie Amirhossein , Bhat Mamatha
Published: April 2024

Graft injury affects over 50% of liver transplant (LT) recipients, but non-invasive biomarkers to diagnose and guide treatment are currently limited. We aimed to develop a biomarker of graft injury by integrating serum metabolomic profiles with clinical variables. Serum from 55 LT recipients with biopsy confirmed metabolic dysfunction-associated steatohepatitis (MASH), T-cell mediated rejection (TCMR) and biliary complications was collected and processed using a combination of LC-MS/MS assay. The metabolomic profiles were integrated with clinical information using a multi-class Machine Learning (ML) classifier. The model’s efficacy was assessed through the Out-of-Bag (OOB) error estimate evaluation. Our ML model yielded an overall accuracy of 79.66% with an OOB estimate of the error rate at 19.75%. The model exhibited a maximum ability to distinguish MASH, with an OOB error estimate of 7.4% compared to 22.2% for biliary and 29.6% for TCMR. The metabolites serine and serotonin emerged as the topmost predictors. When predicting binary outcomes using three models: Biliary (biliary vs. rest), MASH (MASH vs. rest) and TCMR (TCMR vs. rest); the AUCs were 0.882, 0.972 and 0.896, respectively. Our ML tool integrating serum metabolites with clinical variables shows promise as a non-invasive, multi-class serum biomarker of graft pathology.
Total Content and Composition of Phenolic Compounds from Filipendula Genus Plants and Their Potential Health-Promoting Properties
Authors: Sokolova Ekaterina , Krol Tatiana , Adamov Grigorii , Minyazeva Yulia , Baleev Dmitry , Sidelnikov Nikolay
Published: April 2024

This current article was dedicated to the determination of the composition of phenolic compounds in extracts of four species of the genus Filipendula in order to establish a connection between the composition of polyphenols and biological effects. A chemical analysis revealed that the composition of the extracts studied depended both on the plant species and its part (leaf or flower) and on the extractant used. All four species of Filipendula were rich sources of phenolic compounds and contained hydrolyzable tannins, condensed tannins, phenolic acids and their derivatives, and flavonoids. The activities included data on those that are most important for creating functional foods with Filipendula plant components: the influence on blood coagulation measured by prothrombin and activated partial thromboplastin time, and on the activity of the digestive enzymes (pancreatic amylase and lipase). It was established that plant species, their parts, and extraction methods contribute meaningfully to biological activity. The most prominent result is as follows: the plant organ determines the selective inhibition of either amylase or lipase; thus, the anticoagulant activities of F. camtschatica and F. stepposa hold promise for health-promoting food formulations associated with general metabolic disorders.
Azulene and Its Derivatives as Potential Compounds in the Therapy of Dermatological and Anticancer Diseases: New Perspectives against the Backdrop of Current Research
Authors: Slon Emilia , Slon Bartosz , Kowalczuk Dorota
Published: April 2024

The scientific article focuses on the role of azulene and its derivatives in the therapy of dermatological diseases, presenting the latest laboratory and clinical research as well as prospects for further studies. In a synthetic literature review, various databases such as PubMed, Scopus, Web of Science, and the Database of Polish Scientific Journals were queried to select relevant articles concerning azulene. The conclusions drawn from the thematic analysis of the studies emphasize the multifaceted pharmacological actions of azulene and its derivatives including their anti-inflammatory properties, potential anticancer effects, photoprotective abilities, alleviation of itching, management of atopic dermatitis, and treatment of erectile dysfunction. However, there are certain limitations associated with the application of unmodified azulene on the skin, particularly related to photodecomposition and the generation of reactive oxygen species under UV radiation. These effects, in turn, necessitate further research on the safety of azulene and azulene-derived substances, especially regarding their long-term use and potential application in phototherapy. The authors of this work emphasize the necessity of conducting further preclinical and clinical studies to fully understand the mechanisms of action. Incorporating azulene and its derivatives into the therapy of dermatological disorders may represent an innovative approach, thereby opening new treatment avenues for patients.
Mn2Ga2S5 and Mn2Al2Se5 van der Waals Chalcogenides: A Source of Atomically Thin Nanomaterials
Authors: Chernoukhov Ivan V. , Bogach Alexey V. , Cherednichenko Kirill A. , Gashigullin Ruslan A. , Shevelkov Andrei V. , Verchenko Valeriy Yu.
Published: April 2024

Layered chalcogenides containing 3d transition metals are promising for the development of two-dimensional nanomaterials with interesting magnetic properties. Both mechanical and solution-based exfoliation of atomically thin layers is possible due to the low-energy van der Waals bonds. In this paper, we present the synthesis and crystal structures of the Mn2Ga2S5 and Mn2Al2Se5 layered chalcogenides. For Mn2Ga2S5, we report magnetic properties, as well as the exfoliation of nanofilms and nanoscrolls. The synthesis of both polycrystalline phases and single crystals is described, and their chemical stability in air is studied. Crystal structures are probed via powder X-ray diffraction and high-resolution transmission electron microscopy. The new compound Mn2Al2Se5 is isomorphous with Mn2Ga2S5 crystallizing in the Mg2Al2Se5 structure type. The crystal structure is built by the ABCBCA sequence of hexagonal close-packing layers of chalcogen atoms, where Mn2+ and Al3+/Ga3+ species preferentially occupy octahedral and tetrahedral voids, respectively. Mn2Ga2S5 exhibits an antiferromagnetic-like transition at 13 K accompanied by the ferromagnetic hysteresis of magnetization. Significant frustration of the magnetic system may yield spin-glass behavior at low temperatures. The exfoliation of Mn2Ga2S5 layers was performed in a non-polar solvent. Nanolayers and nanoscrolls were observed using high-resolution transmission electron microscopy. Fragments of micron-sized crystallites with a thickness of 70–100 nanometers were deposited on a glass surface, as evidenced by atomic force microscopy.
Synthesis and Application of Salicylhydrazone Probes with High Selectivity for Rapid Detection of Cu2+
Authors: Shi Tianzhu , Xie Zhengfeng , Mo Xinliang , Feng Yulong , Peng Tao , Wu Fuyong , Yu Mei , Zhao Jingjing , Zhang Li , Guo Ju
Published: April 2024

Using the aldehyde amine condensation procedure and the triphenylamine group as the skeleton structure, the new triphenylamine-aromatic aldehyde-succinylhydrazone probe molecule DHBYMH was created. A newly created acylhydrazone probe was structurally characterized by mass spectrometry (MS), NMR, and infrared spectroscopy (FTIR). Fluorescence and UV spectroscopy were used to examine DHBYMH’s sensing capabilities for metal ions. Notably, DHBYMH achieved a detection limit of 1.62 × 10−7 M by demonstrating exceptional selectivity and sensitivity towards Cu2+ ions in an optimum sample solvent system (DMSO/H2O, (v/v = 7/3); pH = 7.0; cysteine (Cys) concentration: 1 × 10−4 M). NMR titration, high-resolution mass spectrometry analysis, and DFT computation were used to clarify the response mechanism. Ultimately, predicated on DHBYMH’s reversible identification of Cu2+ ions in the presence of EDTA, a molecular logic gate was successfully designed.
The Preparation and Dust Suppression Performance Evaluation of Iron Ore Tailing-Based Cementitious Composites
Authors: Nie Miaomiao , Li Shefeng , Li Xuli , Bao Shenxu , Chen Pei , Zhang Yong , Ding Siyu , Li Jiale
Published: April 2024

In order to comprehensively utilize iron ore tailings (IOTs), the possibility of using IOTs as raw materials for the preparation of cementitious composites (IOTCCs) was investigated, and IOTCC was further applied to mine interface pollution control. The mechanical properties, hydration products, wind erosion resistance, and freeze–thaw (F–T) cycle resistance of IOTCCs were evaluated rigorously. The activity index of iron tailings increased from 42% to 78% after grinding for 20 s. The IOTCC was prepared by blending 86% IOT, 10% ground granulated blast-furnace slag (GGBS), and 4% cement clinker. Meanwhile, the hydration products mainly comprised ettringite, calcium hydroxide, and C-S-H gel, and they were characterized via XRD, IR, and SEM. It was observed that ettringite and C-S-H gel were principally responsible for the strength development of IOTCC mortars with an increase in curing time. The results show that the kaolinite of the tailings was decomposed largely after mechanical activation, which promoted the cementitious property of IOT.