bluuebunny/crossref_metadata_2025 huggingface dataset:
The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain
Authors: Tran Norman , Redzic Jasmina S. , Eisenmesser Elan Z. , Holyoak Todd
Published: February 2025

Immunoglobulin A (IgA) proteases are a group of bacterial-derived enzymes that selectivity hydrolyze human IgA in the hinge region that is unique to this immunoglobulin. Several IgA protease (IgAP) families have evolved this ability using both metalloprotease and serine protease chemical mechanisms. One family of metal-dependent IgAPs is the M26 family. This family can be grouped into two subfamilies based upon the presence or absence of a trypsin-like domain found N-terminal to the IgAP domain. The role of this domain in IgAP structure and function is poorly understood. Here, we present the first structural characterization of an M26 IgAP trypsin-like domain from Gemella haemolysans (GhTrp). These structural data demonstrate that the GhTrp domain possesses a trypsin-like fold but contains significant deviations in the surface-loop structure that is known to be coupled to protease selectivity. The lack of observable catalytic function coupled with the structural data suggest that this domain may exist in a pro-enzyme-like state that can potentially be activated when the domain is N-terminally proteolytically excised from the larger M26 IgAP structure.
A riot of blooms begins to dazzle the eye: cognitive behavior with multimodal discourse during usefulness judgments of health information
Authors: Chen Jing , Zhang Lu
Published: February 2025

Purpose

As the two sides of the same coin, usefulness and usability have emerged as pivotal research themes in user experience field. This study compares cognitive effort and cognitive resource allocation strategy across documents varying perceived usefulness and then across documents with different objective usability (unimodal vs multimodal discourses).

Design/methodology/approach

A controlled user study of four identifying tasks related to public health epidemics was conducted to collect data, including document usefulness as perceived by participants, presentation modes of the document and gaze behaviors on each document.

Findings

Usefulness and modality discourse impact cognitive effort and resource allocation strategy in health information search. In useless health documents, spatial encoding resource spending increased significantly with multimodal discourse, and a spatial browsing strategy with an evident exploratory feature was applied; while in useful documents, including low-useful and high-useful, both spatial and information encoding resource spending increased significantly with multimodal discourse, and an information processing strategy with an evident comprehensive feature was applied. Notably, multimodal discourse failed to enhance decision-making effectiveness. Furthermore, in useful documents, the interaction effect of the presentation mode of useful information and multimodal discourse on cognitive effort followed an inverted U-shape pattern.

Originality/value

This paper sheds new light on the interaction effect of usefulness and usability on cognitive effort and resource allocation strategy, highlighting its significance in cognitive effort detecting for multimodal discourse and improving effectiveness and efficacy of health information identification by optimizing information presentation mode design.
Organisational career growth and work engagement: a moderated mediated model
Authors: Okon Samuel Essien , Dakare Olamitunji , Akaighe Godbless Onoriode , Adebiyi Sulaimon Olanrewaju
Published: February 2025

Purpose

Drawing from the conservation of resources theory and organisational justice theory, this study examined the direct and indirect (via career resilience) effects of organisational career growth on work engagement. We further examined the boundary condition of procedure justice in the relationship between organisational career growth, career resilience and work engagement.

Design/methodology/approach

We employed time-lagged data collected in three waves from 431 employees working in the public health sector. Hierarchical regression analysis and Hayes Process Macro were used to test the study hypotheses.

Findings

The findings revealed that organisational career growth has a significant positive direct and indirect influence on work engagement in the presence of career resilience. Also, the boundary condition of procedural justice was significant for employees who perceived procedural justice to be high as opposed to low.

Practical implications

Organisational career growth has a positive influence on employee work engagement. Therefore, public health organisations need to prioritise employee career growth by creating an enabling environment that will help employees' career prospects and mitigate employees’ perception of low procedural justice.

Originality/value

The originality of this study is in empirically establishing career resilience as an underlying mechanism in the relationship between organisational career growth and work engagement while considering the interactive effect of procedural justice. Additionally, the originality of this paper is demonstrated by empirically establishing that a perceived high level of procedural justice helps healthcare employees improve their work engagement, thus deepening our understanding of work engagement amongst health professionals.
Analyzing public discourse on DeFi and CBDC using advanced NLP techniques: insights for financial policy and innovation
Authors: Alamsyah Andry , Astuti Raras Fitriyani
Published: February 2025

Purpose

This study aims to analyze public discourse on decentralized finance (DeFi) and central bank digital currencies (CBDC) using advanced natural language processing (NLP) techniques to uncover key insights that can guide financial policy and innovation. This research seeks to fill the gap in the existing literature by applying state-of-the-art NLP models like BERT and RoBERTa to understand the evolving online discourse around DeFi and CBDC.

Design/methodology/approach

This study uses a multilabel classification using BERT and RoBERTa models alongside BERTopic for topic modeling. Data is collected from social media platforms, including Twitter and LinkedIn, as well as relevant documents, to analyze public sentiment and discourse. Model performance is evaluated based on accuracy, precision, recall and F1-scores.

Findings

RoBERTa outperforms BERT in classification accuracy and precision across all metrics, making it more effective in categorizing public discourse on DeFi and CBDC. BERTopic identifies five key topics frequently discussed, such as financial inclusion, competition and growth in DeFi, with important implications for policymakers.

Practical implications

The insights derived from this study provide valuable information for financial regulators and policymakers to develop more informed, data-driven strategies for implementing and regulating DeFi and CBDC. Public discourse analysis enables policymakers to understand emerging concerns and trends critical for crafting effective financial policies.

Originality/value

This study is among the first to use advanced NLP models, including RoBERTa and BERTopic, to analyze public discourse on DeFi and CBDC. It offers novel insights into the potential challenges and opportunities these innovations present. It contributes to the growing body of research on the intersection of digital financial technologies and public sentiment.
Energy efficiency assessment in CPTPP countries through the three-stage SBM-DEA model
Authors: Tran Mai Ngoc
Published: February 2025

Purpose

The purpose of this study is to evaluate and address the energy efficiency prevalent within the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) countries, a diverse group that constitutes a significant portion of the global gross domestic product. By assessing energy efficiency, the study aims to inform strategies that foster sustainable economic growth and environmental sustainability within these nations.

Design/methodology/approach

This research uses a three-stage slacks-based measure data envelopment analysis (SBM-DEA) model, enhanced by stochastic frontier analysis (SFA), to assess the energy efficiency of CPTPP countries over the period from 2000 to 2015. The three-stage SBM-DEA model allows for a comprehensive analysis by first measuring energy efficiency, then adjusting for external environmental factors and statistical noise through SFA, and finally, reevaluating efficiency with adjusted inputs.

Findings

The analysis reveals significant disparities in energy efficiency among CPTPP nations, identifying both high-performing countries and those needing considerable improvements. Developed countries within the CPTPP generally exhibit higher energy efficiency levels, which can be attributed to their adoption of advanced technologies and strong policy frameworks. In contrast, developing nations demonstrate greater vulnerability to external environmental factors affecting their energy efficiency.

Originality/value

The research fills a gap in the literature by providing a nuanced and comprehensive evaluation of energy efficiency across a significant and economically diverse group of nations, offering valuable insights for sustainable development within the CPTPP framework.
An empirical investigation of the impact of lean manufacturing practices on corporate social performance: a sociotechnical perspective
Authors: Zaidi Ali , Lakhal Lassaad
Published: February 2025

Purpose

The purpose of this paper is to investigate the unique and interactive effects of hard lean practices (HLPs) and soft lean practices (SLPs) on corporate social performance (CSP), as well as the moderating effect of lean maturity on the relationships between each type of practices and CSP.

Design/methodology/approach

Adopting a purely quantitative approach, a survey-based questionnaire methodology was used as a tool to collect data from 127 manufacturing companies located in Tunisia, and a Partial Least Squares Structural Equation Modeling (PLS-SEM) approach was employed to analyze the collected data and validate the research hypotheses.

Findings

The study findings indicate that, firstly, HLPs negatively affect CSP; secondly, SLPs positively influence CSP; and thirdly, the interaction effect of HLPs and SLPs is negative regarding CSP. Additionally, the moderating effect of lean maturity on the relationship between HLPs, SLPs and CSP was found to be insignificant.

Research limitations/implications

This study is limited to manufacturing companies in Tunisia, and its results cannot reflect other geographical contexts.

Practical implications

The current research provides valuable insights for practitioners by showing the importance of SLPs, in particular, in enhancing CSP.

Originality/value

This research provides new insights into the various findings and conclusions reached by previous studies in the literature regarding the impact of lean manufacturing practices on CSP by highlighting the unique and interactive effect of HLPs and SLPs on CSP.
A framework of motivations that drive communicative resistance and cooperation in interviews: perspectives from the field
Authors: Brimbal Laure , Meissner Christian A. , Kleinman Steven M. , Martinez Kevin D. , Doyle Madison K. , Quinby Elizabeth A. , Perry Alexander D. , Mindthoff Amelia
Published: February 2025

Purpose

This study aims to investigate suspects underlying motivations to resist cooperation during investigative interviews. The authors propose a tripartite framework (i.e. concerns for identity, relational and instrumental reasons) for understanding motivations to resist, tested through three qualitative studies.

Design/methodology/approach

The authors coded semi-structured debriefs about investigators’ experiences with communicative resistance throughout their careers (n = 40; Study 1), with particularly resistant suspects (n = 18; Study 2) and with both investigators and their suspects (n = 11; Study 3). Coders identified examples illustrative of subcategories within the framework.

Findings

The authors found that both investigators and suspects cite various motivations to resist. The participants also highlighted the importance of considering these motivations when devising how to mitigate resistance within an investigative interview.

Originality/value

This research examines the understudied topic of communicative resistance and begins to examine motivations that might underlie the phenomenon. Eliciting and understanding suspects’ resistance motivations should be an important component of mitigating resistance using a rapport-based model.
Domestic violence and the spatial-moral order of home in calls to police
Authors: Tennent Emma , Richardson Emma
Published: February 2025

Purpose

Domestic violence is a global problem that reached new visibility during the COVID-19 pandemic. Lockdowns were predicated on the idea of home as a site of safety. Yet for many people, home is a site of violence and abuse. This study aims to document how lockdowns provided a new form of spatial-moral order where previously ordinary activities of coming or going from home took on new moral meanings.

Design/methodology/approach

This paper uses discursive psychology and conversation analysis to examine calls to police about violence made during lockdown. The data are 200 calls to emergency and non-emergency police lines in New Zealand and the United Kingdom. We analyse how callers describe movements to and from home as policeable matters and how call-takers respond to those descriptions.

Findings

Callers described others’ behaviours as transgressions of the spatial-moral order of lockdown. Call-takers responded in different ways that configured lockdown breaches as either relevant policeable problems or as matters of personal responsibility. Descriptions which cast the problem as “live” occasioned a police response, while those that did not convey the same urgency were met with advice to resolve the matter locally.

Originality/value

Examining interactions between callers and call-takers provides unique insights into how movement to and from home was understood as possibly policeable during lockdown. Our interactional approach highlights how understandings of “criminal behaviour” are accomplished and negotiated in real-life encounters. We also uniquely illustrate callers’ fears from their own perspective and how these are met with different institutional responses.
Game-based learning for cybersecurity: enterprise implications from testing competing theories involving immersion, cognitive load and autonomy
Authors: Rajendran Dixon Prem Daniel , Rangaraja Sundarraj P
Published: February 2025

Purpose

In this paper, we propose and test a conceptual model of how the psychological constructs of immersion, cognitive load (CL) and perceived autonomy (PA) relate to the performance of users at cybersecurity games.

Design/methodology/approach

We test the proposed model through an experimental study of 208 participants who play a cybersecurity game and answer a survey. We use structural equation modeling to test our hypotheses and further compute Shapley values to assess the contribution of each construct to game outcomes.

Findings

Results reveal that immersion is an important explanator of CL, PA and outcome. Additionally, our statistical tests show how the inclusion of CL in the conceptual model brings out the relation between autonomy and game-outcome.

Originality/value

This study combines constructs stemming from different theories to propose a conceptual model that better explains game performance. The findings will help enhance learner engagement and motivation. In turn, this can potentially add value to designing cost-effective training methods that can address the growing range of cybersecurity issues in enterprises.
The impact of lean inventory management on ESG performance
Authors: Wang Jingbin , Zhang Yongkang , Yao Xinyan , Zhu Xuechang
Published: February 2025

Purpose

This study investigates the nonlinear relationship between inventory leanness and ESG (environmental, social and governance) performance, exploring how market concentration and digital transformation moderate this connection in manufacturing enterprises.

Design/methodology/approach

Using a large panel data collected from Chinese listed manufacturing enterprises over the period from 2012 to 2021, this research employs the instrumental variable method combined with two-stage least squares estimators to explore the U-shaped relationship between inventory leanness and ESG performance. Furthermore, the moderating roles of market concentration and digital transformation are demonstrated.

Findings

The results reveal an inverted U-shaped relationship between inventory leanness and ESG performance, indicating that moderate lean inventory management enhances ESG outcomes, but excessive reduction hinders them. Additionally, market concentration and digital transformation positively moderate this relationship, suggesting that competitive market conditions and technological advancement mitigate the adverse effects of overly lean inventories.

Practical implications

Managers are advised to balance inventory management with market dynamics and embrace digital transformation to optimize ESG performance. Policymakers can leverage these insights to guide firms in sustainable inventory practices.

Originality/value

This study contributes to the literature by unveiling the nonlinear dynamics between inventory leanness and ESG performance and highlighting the moderating roles of market concentration and digital transformation.
Workplace learning in mentoring (WPLM): a scale development and validation study
Authors: Ghosh Rajashi , Manongsong Ague Mae
Published: February 2025

Purpose

There is a lack of application of the adult learning theories as a framework to explore how mentors can encourage mentees to practice different workplace learning approaches. The purpose of this study is to construct and present evidence for the validity and reliability of a scale termed workplace learning in mentoring (WPLM).

Design/methodology/approach

Study 1 generated items for the WPLM through multiple phases, including input from graduate students (n = 132) and subject matter experts (n = 15). Study 2 focused on validating the scale using exploratory and confirmatory factor analyses to establish a final factor structure. A series of validation analyses (predictive, convergent and discriminatory) were conducted using regression, correlations and structural equation modeling (Sample 1 = 379; Sample 2 = 212).

Findings

In Study 1, the authors generated items and examined content validity, resulting in a four-factor, 20-item scale. Study 2 refined the final WPLM scale to three factors with 15 items. Validation analyses indicated that the WPLM had strong predictive, convergent and discriminatory validity. Specifically, it significantly predicted mentoring satisfaction and quality, converged with traditional, relational and negative mentorship constructs, and was distinct from relationship and personal learning in mentoring.

Research limitations/implications

While this study advances the understanding of WPLM, future research should explore more diverse samples, as the participants were predominantly Caucasian from the global north. Further research should also examine the role of specific work contexts and how mentors create conditions for different learning approaches.

Originality/value

This study highlights the importance of mentors’ role in encouraging learning as an organizational outcome that enriches employees by enhancing their knowledge, skills and abilities.
The transition of leadership via accounting practices: the case of a Chinese entrepreneurial firm
Authors: Li Jiafan , Smith Julia A.
Published: February 2025

Purpose

Accounting changes that take place in the context of different leadership styles, especially in SMEs, require further investigation. This paper aims to explore how accounting enhances monitoring and control for legalistic leaders and how accounting changes facilitate leadership transition to resolve accounting issues and emotional conflicts within entrepreneurial firms.

Design/methodology/approach

This paper adopts a case study in a Chinese entrepreneurial firm to explore the relationship between accounting changes and leadership behaviours rooted in the traditional Chinese philosophies.

Findings

Legalistic leaders enhance monitoring and control, through the flow and interpretation of accounting information, to retain power. However, rule-based accounting order, with rewards and punishment, may create emotional conflicts. The difficulties of implementing accounting changes facilitate legalistic leaders to embrace transformational leadership to resolve trust, emotional conflicts and accounting issues.

Originality/value

This paper provides insights into the transition of leadership styles in the process of implementing accounting changes in the Chinese context, which contributes to future comparative leadership and accounting practices with Western philosophies.
Strategies to achieve work–family balance in a home office using border theory: case study of Mexican university employees
Authors: Llanos Luis Felipe , Tallabs Rebeca , Sánchez Armida , Jure Selen
Published: February 2025

Purpose

This study aims to determine if Boundary Theory remains relevant for achieving work–family balance in a mandatory home office environment and to create a comprehensive inventory of strategies aligned with this theory that workers could use to restore boundaries between work and family life.

Design/methodology/approach

A voluntary and non-random sample of 443 subjects from a private university in Mexico was included. Data were collected using a single, open-ended question to capture the strategies followed to separate work from family (and vice versa). A qualitative technique of coding and content analysis was employed to interpret the data received.

Findings

The study describes and interprets the ten main strategies identified to reinforce the boundaries between family and work life. In particular, two main strategies are used by workers at home: creating effective agendas and maintaining the discipline to adhere to them.

Practical implications

Workers at home could adopt two effective strategies to repair these work-family boundaries: creating agendas to manage their tasks and obligations and maintaining the discipline to adhere to them.

Originality/value

This research demonstrates that boundary theory remains highly applicable for achieving work–family balance in a mandatory home office environment, where work and family coexist in the same space and time.
Sustainable consumption in fashion – the role of public self-consciousness and a comparison of existing-consumers versus new-consumers
Authors: Jawed Fahad , Iqbal Sana , Bilal Ahmad , Amir Fahad
Published: February 2025

Purpose

The study examines the factors contributing to young consumers’ preloved clothing purchase intention and behavior.

Design/methodology/approach

Data was collected from 301 respondents using quantitative methodology. PLS Structural Equation Modelling (SEM) was performed to test hypotheses. The study extends the Theory of Reasoned Action by incorporating the Value-Belief-Norm theory to explore environmental consciousness in sustainable behaviors. It integrates public self-consciousness in the relationship of purchase intention with purchase behavior and employs Multi-Group Analysis to compare existing-consumers' purchase intentions with those of new-consumers.

Findings

Consumers prioritizing environmental consciousness, frugality and subjective norms have higher preloved purchase intentions. Purchase intention mediates the relationship between environmental consciousness, subjective norms and purchase behavior. Consumers with high public self-consciousness tend to follow through with their purchase intentions. Moreover, price-conscious existing-consumers of preloved clothing have higher re-purchase intentions.

Research limitations/implications

Marketers and policymakers aiming to promote sustainable fashion could leverage environmental consciousness, price consciousness and societal pressures in awareness campaigns. Moreover, the study underscores the significance of public self-consciousness and prior preloved purchases in determining future consumption.

Originality/value

The study advances the understanding of the unexplored behaviors of young preloved clothing consumers in Pakistan, the second largest importer of preloved clothes and an under-researched market for such consumption. By integrating public self-consciousness and prior preloved purchases in the TRA framework, the study contributes to limited research exploring the role of individual traits and preferences in influencing sustainable fashion consumption.
Spatiotemporal analysis and GIS-based dashboard development for urban household waste
Authors: Xu Shixiong , Shirowzhan Sara , Sepasgozar Samad
Published: February 2025

Purpose

This paper aims to develop a methodology for the spatiotemporal analysis of urban household waste data and a geographic information system (GIS)-based dashboard for interactive outcomes that identifies emerging trends and spatial distribution.

Design/methodology/approach

The study visualized the emerging hotspot analysis of household waste data covering the waste in selected areas from 2014 to 2019 in New South Wales, Australia. Through analyses in ArcGIS Pro, multiple maps and diagrams can be created to display these results in ArcGIS Insights. To enable the spatial waste analysis outcomes accessible, a GIS-based dashboard including maps and charts, spatiotemporal visualization of household waste tonnage, and emerging hotspots was created.

Findings

Based on the development of the dashboard in the ArcGIS Suites, there is an accessible data pipeline from ArcGIS Pro to Insights. The cloud-mapping system in ArcGIS online serves as a foundation for temporary data storage. The results also show the emerging hotspots of recyclable, residual and organic (RRO) waste in the Greater Sydney Region, Wollongong, Newcastle and Tweed. This study found an emerging cold spot in Wagga Wagga.

Practical implications

A dashboard for monitoring waste streams can be developed to enable GIS specialists to use historical spatiotemporal datasets in ArcGIS suites easily. Policymakers, strategy developers, urban waste managers and organizations dealing with urban waste can utilize this analytical dashboard to identify the issues, patterns and trends concerning urban waste for better decision-making in allocating required resources to overcome the identified issues to make informed decisions and develop strategies to alleviate the trends and patterns of ongoing problems. Indeed, the GIS-based dashboard developed in this research provides deep analysis and insights from the spatial waste data, allowing them to understand the included insights at a glance quickly.

Originality/value

Deriving location information for urban household waste data is crucial for waste management since it offers a better understanding of urban household waste data patterns, issues and historical trends. Small-scale studies have examined spatial waste patterns, but the investigation of urban household waste focusing on RRO waste is limited. Moreover, there is a lack of GIS-based dashboard development to enable spatiotemporal waste analysis outcomes to be publicly accessible.
Uncovering key success factors for enhanced office-site communication through digital twins
Authors: Chalipour Azita , Noorzai Esmatullah , Golabchi Mahmood , Hosseini Nourzad Seyed Hossein
Published: February 2025

Purpose

This study aims to explore the transformative potential of digital twins (DTs) in the construction industry by addressing challenges and bridging the technology adoption gap. Focusing on construction offices, on-site environments and their interface, the research identifies key success factors for DT implementation. Emphasizing practical applications, the study foresees a substantial impact on project management, highlighting the pivotal role of DTs in reshaping the construction sector.

Design/methodology/approach

We reviewed 30 variables within the DT literature, classifying investigations into three main domains: on-site environments, office environments and site-office interface in construction projects. We employed a questionnaire to examine variables, with collected data analyzed using SmartPLS version 4 software. Confirmatory analysis and structural equation modeling rigorously assessed the model’s reliability, validity and predictive utility.

Findings

The study identifies 11 critical factors crucial for successfully implementing DTs in construction projects, emphasizing contributions from office-related (ORF), site-related (SRF) and office-site-related factors (OSRF). Notably, impactful contributions from ORF affirm its pivotal role. The research sheds light on specific aspects within construction offices, on-site environments and their interface, providing valuable insights for industry stakeholders, policymakers and researchers.

Originality/value

Despite discussions on DT’s potential, a research gap exists in addressing essential factors for its effective application in monitoring and optimizing construction projects throughout their lifecycle. This study fills this gap by identifying and categorizing these factors, enhancing the knowledge base for successful DT assimilation and emphasizing the need for practitioners to understand key factors crucial for its integration into construction processes.
Time in range—A new gold standard in type 2 diabetes research?
Authors: Goshrani Ashni , Lin Rose , O'Neal David , Ekinci Elif I.
Published: February 2025

Glycated haemoglobin (HbA1c) is currently the gold standard outcome measure for type 2 diabetes trials. Time in range is a continuous glucose monitoring (CGM) metric defined as the proportion of time in euglycemia (3.9–10.0 mmol/L) and may be valuable not only in type 1 diabetes clinical trials but also as an endpoint in type 2 diabetes trials. This narrative review aimed to assess the relative merits of time in range versus HbA1c as outcome measures for type 2 diabetes studies. It reviews the strengths and limitations of time in range as an outcome measure and evaluates studies in type 2 diabetes that have used time in range as a primary or secondary outcome measure. A literature search was conducted on PubMed and MEDLINE databases using key terms “time in range” AND “diabetes” OR “type 2 diabetes mellitus”. Further evidence was obtained from relevant references of retrieved articles. Literature search identified 247 papers, of which 110 were included in this review. These included a broad range of articles, including 45 randomized trials using time in range as an outcome measure in patients with type 2 diabetes, as well as papers validating time in range. Time in range provides valuable and clinically relevant information and should be used as an important endpoint in type 2 diabetes in clinical trial settings, in conjunction with HbA1c.
Dimensiones de evaluación de impacto de políticas públicas agrícolas: una revisión sistemática de literatura
Authors: Álvarez-Gómez Hernest-Adel , Escobar-Sierra Manuela , Polanco Jorge-Andrés
Published: February 2025

La práctica de la evaluación de impacto de políticas experimenta un aumento debido a que los organismos internacionales y la comunidad académica son cada vez más conscientes de la necesidad de mejorar las evidencias con las que se formulan y ajustan las políticas. Asimismo, es necesario que las políticas agrícolas promuevan la sostenibilidad agrícola que es socialmente justa, ecológica y económicamente viable. No obstante, la sostenibilidad incluye incertidumbres, complejidad y es multidimensional. Por lo tanto, esta investigación busca conocer el estado actual de la discusión sobre las dimensiones que inciden en la evaluación de impacto de las políticas públicas agrícolas. Se realiza una revisión sistemática de literatura mediante un enfoque mixto secuencial, primero, cuantitativo mediante un análisis bibliométrico, segundo, cualitativo con un análisis de contenido utilizando las técnicas de PRISMA y Snowball para definir la muestra de 80 documentos. Los resultados indican que las dimensiones que inciden en la evaluación de impacto de las políticas agrícolas son la social, ambiental, económica, cultural e institucional, además, se vincula el desempeño de la gobernanza en la forma como se producen los efectos. La propuesta permite la estimación profunda de los impactos de una política agrícola. Las implicaciones teóricas giran en torno a que la sostenibilidad se debe comprender más allá de las tres dimensiones clásicas y abarca las dimensiones cultural e institucional, asimismo, propone que la evaluación de una política integre los tres momentos de la evaluación. Se recomienda realizar la verificación empírica del modelo conceptual propuesto.
Discussion: “Viscous Dissipation and Joule Heating Effects on 3D Magnetohydrodynamics Flow of Williamson Nanofluid in a Porous Medium Over a Stretching Surface With Melting Condition” (Tarakaramu, N., Sivakumar, N., Satya Narayana, P. V., and Sivajothi, R., 2022, ASME Open J. Eng., 1, p. 011033)
Authors: Pantokratoras Asterios
Published: February 2025

In the present discussion, many errors have been found in the aforementioned paper and have been corrected.
Environmental ticks in rural and peri urban areas of Ariquemes region, Rondonia, Western Amazon, Brazil
Authors: Nunes da Costa-Silva Ivaneide , De Abreu Rangel Aguirre Andre , Angélica Alves Pedrão Ferreira Silva Bárbara , Da Cunha Santana Irizon , Paiva dos Santos Vanessa , Valério Garcia Marcos , Andreotti Renato , Fernandes Medeiros Jansen
Published: February 2025

Rondonia state reports more spotted fever (SF) cases than any other state in the Brazilian Amazon. Ariquemes is the only municipality that has reported SF cases in this state, but no information has been obtained about the tick and Rickettsia spp. responsible. This study aimed to describe the free-living tick fauna and search for rickettsial DNA in ticks collected from a region where one specific infection was most likely acquired. Ticks were collected at four sites in Ariquemes municipality, and at one site in both Alto Paraíso and Rio Crespo municipalities. A total of 1082 ticks and eight larvae clusters were collected, comprising 12 species from the genus Amblyomma. The most abundant tick species found in this study were Amblyomma oblongoguttatum, A. scalpturatum and A. naponense. All ticks were tested for the presence of citrate synthase (gltA) and the outer membrane protein A (ompA) gene fragments to detect any Rickettsia. No rickettsiae amplification was observed; however, we did record the presence of A. ovale in the region, including at the probable site infection for a human spotted fever case. This tick is a known vector of Rickettsia parkeri Atlantic rainforest strain in Brazil. These results reinforce the need for further studies of ticks and tick-borne agents in order to improve our knowledge of tick-borne diseases in the Amazon at large.
Contribution to knowledge of the oribatid mite genus Dimidiogalumna (Acari, Oribatida, Galumnidae)
Authors: Ermilov Sergey G. , Kontschán Jenő
Published: February 2025

Dimidiogalumna (Oribatida, Galumnidae) currently comprises seven species collectively distributed in the Paleotropical and southern Palaearctic regions. We describe a new species—D. dhatywalalensis sp. nov.—based on adults collected from litter in a bamboo forest in Western Ethiopia. The new species differs from all known species of the genus by the presence of a specific tuberculate sculpturing in the anterolateral part of the pteromorph. An identification key and summary of distribution and habitats of the known species of Dimidiogalumna are provided.
Structural, electrical, and thermal characterization of homoepitaxial close-injection showerhead metalorganic chemical vapor deposition β-Ga2O3 enhancement-mode recessed-gate MOSFETs
Authors: Masten Hannah N. , Alvarez Gustavo Armando , Halverson Corey , Christiansen-Salameh Joyce , Kwon Eugene Y. , Liao Michael , Lundh James Spencer , Gutierrez Audrey Rose , Alema Fikadu , Osinsky Andrei , Jacobs Alan G. , Goorsky Mark S. , Weber Marc H. , Tian Zhiting , Hobart Karl D. , Tadjer Marko J.
Published: February 2025

A systematic investigation was performed on the impact of the β-gallium oxide (Ga2O3) epitaxial buffer layer thickness grown by close-injection showerhead metalorganic chemical vapor deposition (CIS-MOCVD) on the film’s structural, electrical, and thermal characteristics. Varying thicknesses of unintentionally doped β-Ga2O3 epitaxial layers were grown by CIS-MOCVD on Fe-doped (010) β-Ga2O3 substrates, followed by a 10 nm β-Ga2O3 Si-doped layer with a Si concentration of 1019 cm−3. Gate-recessed lateral metal–oxide–semiconductor field-effect transistors were fabricated with these epilayer films. The device characteristics and secondary ion mass spectroscopy results highlighted the need for precise Si doping within the channel, as well as minimizing the Si accumulation at the epilayer-substrate interface for proper device operation. The results from positron annihilation spectroscopy did not indicate a strong correlation between the epilayer thickness and Ga-related vacancies, and the thermal conductivities of the epilayers were consistent with increasing thickness as shown in the device-level frequency-domain thermoreflectance analysis.
13
C hyperpolarization with nitrogen-vacancy centers in micro- and nanodiamonds for sensitive magnetic resonance applications
Authors: Blinder Rémi , Mindarava Yuliya , Korzeczek Martin , Marshall Alastair , Glöckler Felix , Nothelfer Steffen , Kienle Alwin , Laube Christian , Knolle Wolfgang , Jentgens Christian , Plenio Martin B. , Jelezko Fedor
Published: February 2025

Nuclear hyperpolarization is a known method to enhance the signal in nuclear magnetic resonance (NMR) by orders of magnitude. The present work addresses the
13
C hyperpolarization in diamond micro- and nanoparticles, using the optically pumped nitrogen-vacancy center (NV) to polarize
13
C spins at room temperature. Consequences of the small particle size are mitigated by using a combination of surface treatment improving the
13
C relaxation (
T
1
) time, as well as that of NV, and applying a technique for NV illumination based on a microphotonic structure. Adjustments to the dynamical nuclear polarization sequence (PulsePol) are performed, as well as slow sample rotation, to improve the NV-
13
C polarization transfer rate. The hyperpolarized
13
C NMR signal is observed in particles of 2-micrometer and 100-nanometer median sizes, with enhancements over the thermal signal (at 0.29-tesla magnetic field) of 1500 and 940, respectively. The present demonstration of room-temperature hyperpolarization anticipates the development of agents based on nanoparticles for sensitive magnetic resonance applications.
Approaching infinite selectivity in membrane-based aqueous lithium extraction via solid-state ion transport
Authors: Patel Sohum K. , Iddya Arpita , Pan Weiyi , Qian Jianhao , Elimelech Menachem
Published: February 2025

As the gap between lithium supply and demand continues to widen, the need to develop ion-selective technologies, which can efficiently extract lithium from unconventional water sources, grows increasingly crucial. In this study, we investigated the fundamentals of applying a solid-state electrolyte (SSE), typically used in battery technologies, as a membrane material for aqueous lithium extraction. We find that the anhydrous hopping of lithium ions through the ordered and confined SSE lattice is highly distinct from ion migration through the hydrated free volumes of conventional nanoporous membranes, thus culminating in unique membrane transport properties. Notably, we reveal that the SSE provides unparalleled performance with respect to ion-ion selectivity, consistently demonstrating lithium ion selectivity values that are immeasurable by even the part-per-billion detection limit of mass spectrometry. Such exceptional selectivity is shown to be the result of the characteristic size and charge exclusion mechanisms of solid-state ion transport, which may be leveraged in the design of next-generation membranes for resource recovery.
A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity
Authors: Pollock Liam , Georgiou Ioanna Ch. , Rusilowicz-Jones Emma V. , Clague Michael J. , Urbé Sylvie
Published: February 2025

The Parkinson’s disease–linked kinase, PINK1, is a short-lived protein that undergoes cleavage upon mitochondrial import leading to its proteasomal degradation. Under depolarizing conditions, it accumulates on mitochondria where it becomes activated, phosphorylating both ubiquitin and the ubiquitin E3 ligase Parkin, at Ser
65
. Our experiments reveal that in retinal pigment epithelial cells, only a fraction of PINK1 becomes stabilized after depolarization by electron transport chain inhibitors. Furthermore, the observed accrual of PINK1 cannot be completely accounted for without an accompanying increase in biosynthesis. We have used a ubiquitylation inhibitor TAK-243 to accumulate cleaved PINK1. Under these conditions, generation of unconjugated “free” phospho-ubiquitin serves as a proxy readout for PINK1 activity. This has enabled us to find a preconditioning phenomenon, whereby an initial depolarizing treatment leaves a residual pool of active PINK1 that remains competent to seed the activation of nascent cleaved PINK1 following a 16-hour recovery period.
A plant virus manipulates both its host plant and the insect that facilitates its transmission
Authors: Liang Peng , Zeng Yang , Ning Jie , Wu Xiaojie , Wang Wenlu , Ren Jun , Wu Qingjun , Yang Xin , Wang Shaoli , Guo Zhaojiang , Su Qi , Zhou Xuguo , Turlings Ted C. J. , Xie Wen , Zhang Youjun
Published: February 2025

Tomato yellow leaf curl virus (TYLCV), a devastating pathogen of tomato crops, is vectored by the whitefly
Bemisia tabaci
, yet the mechanisms underlying TYLVC epidemics are poorly understood. We found that TYLCV triggers the up-regulation of two β-myrcene biosynthesis genes in tomato, leading to the attraction of nonviruliferous
B. tabaci
. We also identified BtMEDOR6 as a key whitefly olfactory receptor of β-myrcene involved in the distinct preference of
B. tabaci
MED for TYLCV-infected plants. TYLCV inhibits the expression of BtMEDOR6, canceling this preference and thereby facilitating TYLCV transmission to uninfected plants. Greenhouse experiments corroborated the role of β-myrcene in whitefly attraction. These findings reveal a sophisticated viral strategy whereby TYLCV modulates both host plant attractiveness and vector olfactory perception to enhance its spread.
TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network
Authors: Jones Taylor , Feng Junjie , Luyties Olivia , Cozzolino Kira , Sanford Lynn , Rimel Jenna K. , Ebmeier Christopher C. , Shelby Grace S. , Watts Lotte P. , Rodino Jessica , Rajagopal Nisha , Hu Shanhu , Brennan Finn , Maas Zachary L. , Alnemy Sydney , Richter William F. , Koh Adrian F. , Cronin Nora B. , Madduri Ameya , Das Jhuma , Cooper Elliot , Hamman Kristin B. , Carulli John P. , Allen Mary A. , Spencer Sabrina , Kotecha Abhay , Marineau Jason J. , Greber Basil J. , Dowell Robin D. , Taatjes Dylan J.
Published: February 2025

How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution cryo–electron microscopy revealed how two clinically relevant inhibitors block CDK7 function. In cells, CDK7 inhibition rapidly suppressed transcription, but constitutively active genes were disproportionately affected versus stimulus-responsive. Distinct transcription factors (TFs) regulate constitutive versus stimulus-responsive genes. Accordingly, stimulus-responsive TFs were refractory to CDK7 inhibition whereas constitutively active “core” TFs were repressed. Core TFs (n = 78) are predominantly promoter associated and control cell cycle and proliferative gene expression programs across cell types. Mechanistically, rapid suppression of core TF function can occur through CDK7-dependent phosphorylation changes in core TFs and RB1. Moreover, CDK7 inhibition depleted core TF protein levels within hours, consistent with durable target gene suppression. Thus, a major but unappreciated biological function for CDK7 is regulation of a TF cohort that drives proliferation, revealing an apparent universal mechanism by which CDK7 coordinates RNAPII transcription with cell cycle CDK regulation.
On-surface synthesis of Heisenberg spin-1/2 antiferromagnetic molecular chains
Authors: Sun Kewei , Cao Nan , Silveira Orlando J. , Fumega Adolfo O. , Hanindita Fiona , Ito Shingo , Lado Jose L. , Liljeroth Peter , Foster Adam S. , Kawai Shigeki
Published: February 2025

Magnetic exchange interactions between localized spins in π-electron magnetism of carbon-based nanostructures have attracted tremendous interest due to their great potential for nano spintronics. Unique many-body quantum characteristics, such as gaped excitations, strong spin entanglement, and fractionalized excitations, have been demonstrated, but the spin-1/2 Heisenberg model with a single antiferromagnetic coupling
J
value remained unexplored. Here, we realized the entangled antiferromagnetic quantum spin-1/2 Heisenberg model with diazahexabenzocoronene oligomers (up to 7 units) on Au(111). Extensive low-temperature scanning tunneling microscopy/spectroscopy measurements and density functional theory and many-body calculations show that even-numbered spin chains host a collective state with gapped excitations, while odd-numbered chains feature a Kondo excitation. We found that a given antiferromagnetic coupling
J
value between first neighbors in the entangled quantum states is responsible for the quantum phenomena, strongly relating to their parities of the chain. The tunable molecular building blocks act as an ideal platform for the experimental realization of topological spin lattices.
Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy
Authors: Klenchin Vadim A. , Clark Natasha M. , Keles Nida K. , Capuano Saverio , Mason Rosemarie , Gao Guangping , Broman Aimee , Kose Emek , Immonen Taina T. , Fennessey Christine M. , Keele Brandon F. , Lifson Jeffrey D. , Roederer Mario , Gardner Matthew R. , Evans David T.
Published: February 2025

An alternative to lifelong antiretroviral therapy (ART) is needed to achieve durable control of HIV-1. Here, we show that adeno-associated virus (AAV) delivery of two rhesus macaque antibodies to the simian immunodeficiency virus (SIV) envelope glycoprotein (Env) with potent neutralization and antibody-dependent cellular cytotoxicity can prevent viral rebound in macaques infected with barcoded SIV
mac
239M after discontinuing suppressive ART. After AAV administration, sustained antibody expression with minimal antidrug antibody responses was achieved in all but one animal. After ART withdrawal, SIV replication rebounded within 2 weeks in all control animals but remained <15 copies per milliliter in plasma for more than a year in four of the eight animals that received AAV vectors encoding Env-specific antibodies. Viral sequences from animals that rebounded with delayed kinetics exhibited restricted clonal diversity and antibody escape mutations in Env. Thus, sustained expression of antibodies with potent antiviral activity can afford durable, ART-free containment of pathogenic SIV infection.