bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines
Authors: Razmienė Beatričė , Řezníčková Eva , Dambrauskienė Vaida , Ostruszka Radek , Kubala Martin , Žukauskaitė Asta , Kryštof Vladimír , Šačkus Algirdas , Arbačiauskienė Eglė
Published: November 2021

A library of 2,4,6,7-tetrasubstituted-2H-pyrazolo[4,3-c]pyridines was prepared from easily accessible 1-phenyl-3-(2-phenylethynyl)-1H-pyrazole-4-carbaldehyde via an iodine-mediated electrophilic cyclization of intermediate 4-(azidomethyl)-1-phenyl-3-(phenylethynyl)-1H-pyrazoles to 7-iodo-2,6-diphenyl-2H-pyrazolo[4,3-c]pyridines followed by Suzuki cross-couplings with various boronic acids and alkylation reactions. The compounds were evaluated for their antiproliferative activity against K562, MV4-11, and MCF-7 cancer cell lines. The most potent compounds displayed low micromolar GI50 values. 4-(2,6-Diphenyl-2H-pyrazolo[4,3-c]pyridin-7-yl)phenol proved to be the most active, induced poly(ADP-ribose) polymerase 1 (PARP-1) cleavage, activated the initiator enzyme of apoptotic cascade caspase 9, induced a fragmentation of microtubule-associated protein 1-light chain 3 (LC3), and reduced the expression levels of proliferating cell nuclear antigen (PCNA). The obtained results suggest a complex action of 4-(2,6-diphenyl-2H-pyrazolo[4,3-c]pyridin-7-yl)phenol that combines antiproliferative effects with the induction of cell death. Moreover, investigations of the fluorescence properties of the final compounds revealed 7-(4-methoxyphenyl)-2,6-diphenyl-2H-pyrazolo[4,3-c]pyridine as the most potent pH indicator that enables both fluorescence intensity-based and ratiometric pH sensing.
A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics
Authors: Ye Xiaoqing , Gaucher Jean-François , Vidal Michel , Broussy Sylvain
Published: November 2021

The vascular endothelial growth factor (VEGF) family of cytokines plays a key role in vasculogenesis, angiogenesis, and lymphangiogenesis. VEGF-A is the main member of this family, alongside placental growth factor (PlGF), VEGF-B/C/D in mammals, and VEGF-E/F in other organisms. To study the activities of these growth factors under physiological and pathological conditions, resulting in therapeutic applications in cancer and age-related macular degeneration, blocking ligands have been developed. These have mostly been large biomolecules like antibodies. Ligands with high affinities, at least in the nanomolar range, and accurate structural data from X-ray crystallography and NMR spectroscopy have been described. They constitute the main focus of this overview, which evidences similarities and differences in their binding modes. For VEGF-A ligands, and to a limited extent also for PlGF, a transition is now observed towards developing smaller ligands like nanobodies and peptides. These include unnatural amino acids and chemical modifications for designed and improved properties, such as serum stability and greater affinity. However, this review also highlights the scarcity of such small molecular entities and the striking lack of small organic molecule ligands. It also shows the gap between the rather large array of ligands targeting VEGF-A and the general absence of ligands binding other VEGF members, besides some antibodies. Future developments in these directions are expected in the upcoming years, and the study of these growth factors and their promising therapeutic applications will be welcomed.
Assessment of the In Vivo and In Vitro Release of Chemical Compounds from Vespa velutina
Authors: Rodríguez-Flores M. Shantal , Falcão Soraia I. , Escuredo Olga , Queijo Luis , Seijo M. Carmen , Vilas-Boas Miguel
Published: November 2021

Vespa velutina has been rapidly expanding throughout Galicia since 2012. It is causing human health risks and well-known losses in the beekeeping sector. Control methods are scarce, unspecific, and ineffective. Semiochemicals are insect-derived chemicals that play a role in communication and they could be used an integrated pest management tool alternative to conventional pesticides. A previous determination of the organic chemical profile should be the first step in the study of these semiochemicals. HS-SPME in living individuals and the sting apparatus extraction followed by GC-MS spectrometry were combined to extract a possible profile of these compounds in 43 hornets from Galicia. The identified compounds were hydrocarbons, ketones, terpenes, and fatty acid, and fatty acid esters. Nonanal aldehyde appeared in important concentrations in living individuals. While pentadecane, 8-hexyl- and ethyl oleate were mainly extracted from the venom apparatus. Ketones 2-nonanone, 2-undecanone and 7-nonen-2-one, 4,8-dimethyl- were identified by both procedures, as was 1,7-Nonadiene, 4,8-dimethyl-. Some compounds were detected for the first time in V. velutina such as naphthalene, 1,6-dimethyl-4-(1-methylethyl). The chemical profile by caste was also characterized.
Multiple Binary Classification Model of Trip Chain Based on the Fusion of Internet Location Data and Transport Data
Authors: Wang Wenjing , Chen Yanyan , Sun Haodong , Chen Yusen
Published: November 2021

Observing and analyzing travel behavior is important, requiring understanding detailed individual trip chains. Existing studies on identifying travel modes have mainly used some travel features based on GPS and survey data from a small number of users. However, few studies have focused on evaluating the effectiveness of these models on large-scale location data. This paper proposes to use travel location data from an Internet company and travel data from transport department to identify travel modes. A multiple binary classification model based on data fusion is used to find out the relationship between travel mode and different features. Firstly, we enlisted volunteers to collect travel data and record their travel trip process using a custom-developed WeChat program. Secondly, we have developed three binary classification models to explain how different attributes can be used to model travel mode. Compared with one multi-classification model, the accuracy of our model improved significantly, with prediction accuracies of 0.839, 0.899, 0.742, 0.799, and 0.799 for walk, metro, bike, bus, and car, respectively. This suggests that the model could be applied not only in engineering practice to identify the trip chain from Internet location data but also in decision support for transportation planners.
Approaches to training pharmacists in the Russian Federation
Authors: Golikova Nataliya Sergeevna
Published: November 2021

The paper is devoted to the main trends in the development of higher pharmaceutical education in Russia at the beginning of the 21st century, study of the formation of a new understanding of the profession of pharmacist under the influence of the intensive development of the domestic pharmaceutical industry, relationship of changes in the industry, and the state educational standards in the "Pharmacy" field of study.
Advanced dispenserization: important, convenient, free
Authors: Chumenko Nikolay Leonidovich
Published: November 2021

The relevance of the issue of undergoing an advanced medical examination for persons who have suffered from COVID-19 is due to the vital need to prevent the long-term consequences of the coronavirus: thrombosis, tachycardia, and other pathologies. The article focuses on the fact that citizens can check their health and undergo an advanced medical examination free of charge within the compulsory medical insurance system, as well as on how to sign up for a medical examination and what procedures are available.
Metode Pembelajaran dan Bentuk Penyajian Musik Ansambel Campuran pada Musik Keroncong
Authors: Wamirza Edo , Sihombing Lamhot Basani , Wiflihani Wiflihani
Published: November 2021

Penelitian ini bertujuan untuk membahas tentang proses pembelajaran musik ansambel campuran pada musik keroncong, bentuk penyajian musik ansambel campuran pada musik keroncong, di SMP Muhammadiyah 7 Medan. Teori yang digunakan dalam penelitian ini adalah teori pembelajaran, bentuk penyajian, ansamble, dan keroncong. Metode dalam penelitian ini adalah deskriptif kualitatif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dokumentasi. Hasil penelitian ini menjelaskan bahwa proses pembelajaran musok ansambel campuran pada musik keroncong  di SMP Muhammadiyah 7 Medan dilaksanakan dalam dua kali pertemuan, masing-masing pertemuan terdapat tiga tahap yaitu pendahuluan, inti, dan penutup dengan alokasi waktu 3 x 40 menit.
Основні напрями пошуку ефективних методів державного регулювання господарських зв'язків підприємницьких структур
Authors: Stativka N.V.  , Bubliy M.P.  , Nadtochii A.O.
Published: November 2021

У статті досліджено Основні напрями пошуку ефективних методів державного регулювання господарських зв'язків підприємницьких структур. Доведено об'єктивний характер зростаючої уваги держави до рівня, якості та ефективності господарських зв'язків, що виникають між різними господарюючими суб'єктами. Це пояснюється безліччю різних факторів і явищ, що передбачає пошук адекватного регулюючого механізму, що діє на основі забезпечення компромісу між ринковими (відповідними ідеям підприємництва) і адміністративними інструментами, методами і моделями. При цьому зроблено висновок про те, що наявність ефективної системи державного регулювання господарських зв'язків являє собою один з найважливіших компонентів і умов розвитку підприємницького середовища і всієї національної економіки.
Analisis Usaha Penangkapan Kepiting Bakau (Scylla sp.) Di Kelurahan Kandang, Kota Bengkulu
Authors: Zamdial Zamdial , Muqsit Ali , Herliany Nurlaila Ervina , Aziza Icencye Ayu Nickty
Published: November 2021

Tujuan penelitian ini adalah mendeskripsikan dan menganalisis kelayakan usaha penangkapan kepiting bakau (Scylla sp.) dengan menggunakan alat tangkap bubu lipat di perairan Kelurahan Kandang, Kecamatan Kampung Melayu, Kota Bengkulu. Penelitian dilaksanakan selama 1 bulan pada bulan September 2020. Penelitian ini dilakukan dengan menggunakan metode survei. Responden penelitian terdiri dari 13 orang nelayan usaha penangkapan kepiting bakau yang menggunakan bubu lipat di perairan Kelurahan Kandang. Metode analisis data pada penelitian ini adalah metode deskriptif. Bubu lipat yang digunakan oleh nelayan berukuran panjang 45 cm, lebar 20 cm, dan tinggi 15 cm. Perahu motor tempel yang digunakan nelayan berukuran panjang 4,3 m, lebar 1,1 m, tinggi 0,6 m. Hasil perhitungan gross tonnage perahu motor tempel yaitu 0,63 GT. Mesin yang digunakan berkekuatan 5,5 PK – 6,5 PK dengan merek mesin diantaranya Honda, Nixon, Bion, Proquip dan Pujiama. Daerah penangkapan kepiting bakau di perairan Kelurahan Kandang berada di sekitar perairan hutan mangrove dengan dasar perairan berupa lumpur berpasir, dengan jarak dari base fishing yaitu 2-3 km. Hasil tangkapan utama bubu lipat adalah kepiting bakau (Scylla sp.). Analisis kelayakan usaha penangkapan kepiting bakau dengan menggunakan alat tangkap bubu lipat di perairan Kelurahan Kandang, Kecamatan Kampung Melayu, Kota Bengkulu dinyatakan layak dengan hasil NPV = Rp 2.097.872, Net B/C Ratio = 1,02, IRR = 27% menggunakan tingkat suku bunga deposito Bank BRI 12% dan PP = 2,61 tahun atau 2 tahun 6 bulan 1 hari.
Diversifikasi Pengolahan Produk Cookies Eeg Roll Dengan Penambahan Tepung Ikan Teri
Authors: Junianingsih Ika , Jasila Ismi , Sandra Lovi
Published: November 2021

Ikan teri adalah bahan makanan asal hewani yang merupakan sumber protein dan kaya akan kalsium. Tepung ikan untuk bahan dasar pangan masih sangat jarang pemanfaatannya dibandingkan tepung ikan untuk bahan pakan (ternak) sehingga perlu dilakukan upaya untuk memanfaatkan tepung ikan yang kaya akan kalsium ini untuk berbagai jenis produk pangan. Penambahan tepung ikan teri pada pembuatan produk cookies telur atau egg roll untuk menciptakan makanan ringan atau snack food yang sehat, memiliki nutrisi baik yang dibutuhkan oleh tubuh serta enak dikonsumsi di antara waktu makan utama dalam sehari-hari. Penelitian ini dilakukan bertujuan untuk; 1) Mengetahui proses pengolahan egg roll dengan penambahan tepung ikan teri, dan 2) Mengetahui formulasi penggunaan tepung ikan teri pada pengolahan egg roll. Tahapan penelitian dilakukan melalui 4 tahapan pengolahan; 1) Tahap persiapan alat dan pemilihan bahan baku yang baik, agar menghasilkan egg roll yang berkualitas 2) Tahap pembuatan tepung ikan teri dengan metode pengovenan listrik. 3) Tahap pengolahan adonan egg roll dengan mencampur semua bahan baku step by step 4) Tahap akhir, pemanggangan adonan menggunakan cetakan egg roll. Hasil penelitian menunjukkan penambahan tepung ikan teri dengan formula 30:70 pada adonan dasar egg roll menghasilkan tekstur adonan tidak mudah rapuh dan hancur saat pembetukan/penggulungan adonan. Menghasilkan citarasa renyah dan gurih dengan penampakan coklat kekuningan tanpa bau amis yang mengganggu. Komposisi gizi egg roll dengan penambahan tepung ikan teri menunjukkan rataan nilai protein 60gr, kalsium 2.381 mg, fosfor 1.225 mg, vitamin A 297 SI, dan energy 277 kkal.
Analisis Pemenuhan Persyaratan Ekolabel Global Aquaculture Alliance - Best Aquaculture Practices (GAA-BAP) di Industri Pengolahan Udang PT. XYZ Sidoarjo
Authors: Ariadi Puji Sugeng , Wahyu Yus Isnainita
Published: November 2021

Salah satu sertifikasi ekolabel untuk industri pengolahan udang adalah Best Aquaculture Practices dari Global Aquaculture Alliance (GAA-BAP). Indonesia sebagai salah satu produsen udang terbesar dunia, maka berkepentingan dalam penerapan ekolabel GAA-BAP melalui dukungan regulasi dan mendorong perbaikan penerapan ekolabel yang lebih baik di industri pengolahan udang. Penelitian ini bertujuan untuk mengkaji regulasi yang mendukung penerapan ekolabel GAA-BAP dan menganalisis kondisi aktual dalam memenuhi persyaratan ekolabel GAA-BAP. Metode penelitian yang digunakan yaitu metode deskriptif dengan studi kasus pada industri pengolahan udang beku yaitu PT. XYZ Sidoarjo. Metode analisis dalam mengkaji regulasi ekolabel GAA-BAP adalah metode yuridis empiris. Sedangkan metode analisis kondisi aktual dengan cara penilaian kesesuaian di lokasi studi kasus dibandingkan sub-sub klausul standar persyaratan ekolabel GAA-BAP serta penyusunan rekomendasi perbaikan. Hasil yang didapat dari penelitian adalah industri pengolahan udang sudah mematuhi dan menjalankan regulasi  yang berlaku di Indonesia dan regulasi internasional khususnya negara-negara tujuan ekspor. Hasil penilaian kesesuaian menunjukkan bahwa PT. XYZ sudah memenuhi 100% sub klausul kepemilikan hak, 100% sub klausul sistem manajemen mutu, 75% sub klausul manajemen karyawan, 100% sub klausul manajemen limbah dan lingkungan, 93% sub klausul manajemen keamanan pangan, 90% sub klausul manajemen verifikasi, 100% sub klausul sistem ketertelusuran, dan 96% sudah memenuhi persyaratan tambahan. Rekomendasi perbaikan yang harus dilakukan adalah peningkatan pengawasan fasilitas keselamatan kerja karyawan, melaksanakan program pelatihan penanganan bahan kimia berbahaya, mengimplementasikan prosedur ketahanan pangan, melaksanakan pengujian internal sesuai persyaratan GAA-BAP secara rutin, melakukan audit internal yang mencakup audit sosial dan lingkungan, serta menjamin instalasi limbah dalam kondisi baik untuk operasional.
KERUKUNAN ANTARUMAT BERAGAMA DALAM PERSPEKTIF HUKUM PIDANA
Authors: Esther July
Published: November 2021

Abstract Religious diversity is often a challenge in harmony, there is still statically addressed (exclusive), has not led to a motion proactive in building unity among religious. Harmony among religious believers in the perspective of criminal law refers to one of the articles in the Code of Penal about setting Crimes Against Public Order, namely Article 156a, which is the rider with the Presidential Decree of the Republic of Indonesia Number 1 / the 1965 on the Prevention of Abuse and / or blasphemy. Treatment of the perpetrators either individual or organization or belief is preceded procedural measures and stages of criminal sanctions for perpetrators of violations of Article 1 of the Republic of Indonesia Presidential Decree No. 1 / the 1965 as the final sanction which wants peace.Keywords: harmony, religious communities, the criminal law.
MEMPERLUAS MAKNA ZINA DALAM GUGATAN PERCERAIAN (Studi kasus putusan Pengadilan Agama Tigaraksa No. 1538/Pdt.G/2013/PA.Tgrs)
Authors: Sanjaya Umar Haris
Published: November 2021

Abstract This study focused on discussing the meaning of zina laws that existed at the Compilation of Islamic Law and Government Regulation No. 9 Year 1975 on the implementation of Law No. 1 Year 1974 on Marriage, which the courts in applying the word adultery should also look at the changing patterns of behavior and adultery today. Adultery should no longer be defined as sexual intercourse with the entry of male into the female sex, but the behavior of adultery was bermcam-wide one is oral sex. Behavior oral sex is a matter of a lawsuit against a husband and wife on the grounds of adultery lawsuit, but the court rejected it. This study contains the problem is how judges interpret the word adultery in making judgments in divorce? whether oral sex can be classified into the word adultery? The study found that oral sex by law can not be regarded as adultery, but the act of adultery into. Proof of adultery can only be recognized when the entity relationship entry into the male female sex. In conclusion, the judges interpret the meaning of the word adultery adultery per se, but the behavior of adultery are now widely different patterns and actions. Justice should not only look at the regulations simply make judgments, but look at the pattern of behavior or adultery committed in defining the word adultery.Keywords: adultery, oral sex, meaning law
KAJIAN PERUBAHAN HUKUM DAN PEREKONOMIAN PADA ERA PERDAGANGAN BEBAS DI SEKTOR PERTANIAN
Authors: Ariani Ariani
Published: November 2021

Abstract National economic development has shown the transformation of the economic structure from agriculture to industry, as well as with the development of the law. Economic indicators showed decline in the share of the agricultural sector as well as an increasing share of the industrial sector in the Gross Domestic Product (GDP) can be bukti.Pertanian in Indonesia is at crossroads jalan.Sebagai supporting the livelihood of millions of Indonesian society, the agricultural sector requires a strong economic growth and rapid .Sektor also need to be one of the main components in the program and the government's strategy to alleviate structural kemiskinan.Transformasi between sectors, it appears that with increasing per capita income, the agricultural sector has decreased the share of the GDP, while the industrial sector on the contrary experienced peningkatan.Kebanyakan developing countries today this has been agreed that the development of industry and agriculture as much as possible to walk semultan. Agriculture provides a market for manufactured goods, feed the urban population, be a source of labor and capital to the industrial sector, as well as generate foreign exchange for the import of machinery and raw materials required by the intermediate industri.Prioritas sector policies to increase food production can be done through the use teknologi.Tipe and direction of technological change is influenced by market forces and pemerintah.Selain research funded research in the country, the source of technological progress is a transfer from outside negeri.Program-local research programs in countries developing in some ways is not replaceable by technology the foreign research results.Keywords: Structural Transformation, GDP, Agricultural Sector, Industrial Secto
PENERAPAN PERTANGGUNGJAWABAN PIDANA BADAN USAHA (KORPORASI) DALAM KETENTUAN YANG BERKAITAN DENGAN HUKUM LINGKUNGAN
Authors: Manullang Herlina
Published: November 2021

AbstractMany things in human life has been affected by a legal entity (corporation), if the positive effect is certainly no need to worry, but just a lot of influence has been harmful to individuals and society at large. Criminal Code as the legal basis in criminal legislation only mentions that a criminal act can only be done by an individual (naturlijk person) is not a business entity (corporation). This has led to the growth of various laws outside the Criminal Code that recognizes the position of a business entity (corporation) as subjects of criminal law, especially in the provision of environmental law. Recognition notch business entities (corporations) as the subject of criminal law in environmental law provisions certainly result in the criminal responsibility.Keyword: Legal Entity, environmental Law, Criminal
PEMBATALAN PUTUSAN BADAN PENYELESAIAN SENGKETA KONSUMEN MELALUI PENGADILAN NEGERI
Authors: Manurung Darwis
Published: November 2021

Abstract Litigation dispute resolution is the settlement of a dispute through a court which results in a win and lose decision. The decision gives the one party wins and the other party loses. Non-litigation dispute resolution is the settlement of a dispute outside the court where it produces a win-win solution.Based on the Decree of the Minister of Industry and Trade of the Republic of Indonesia Number: 350 / MPP / Kep / 12/2001 concerning Implementation of Duties and Authorities of the Consumer Dispute Settlement Agency Article 3 Letter a states that the dispute resolution process in BPSK can be pursued in three ways, namely by means of Conciliation, Mediation or Arbitration. Through these three ways of resolving it is expected to produce a decision that provides a win-win solution for the parties. However, it is inevitable that in reality not all decisions made by BPSK with this arbitration will give satisfaction to the parties.The purpose of writing this paper is to find out the authority of the District Court to cancel the BPSK Decision and also know how to file an objection to the BPSK Decision.The authority of the District Court to cancel the BPSK Arbitration verdict is based on Article 58 UUPK and Article 41 paragraph (3) Decree of the Minister of Industry and Trade of the Republic of Indonesia Number 350 / MPP / Kep / 12/2001.
KEDUDUKAN HUKUM PERKAWINAN ADAT DAYAK LUNDAYEH DALAM HUKUM PERKAWINAN NASIONAL
Authors: Bilung Pasri
Published: November 2021

AbstractThe procedure of marriage which is carried out in a customary manner and has existed before the State of Indonesia was established, as carried out by the Lundayeh Dayak community and until now is still maintained as a local culture of ancestral heritage is a tradition that is still highly upheld. Unification in the field of marital law through the establishment of Law No. 1 of 1974 has legal consequences for marital arrangements in Indonesia. So that it raises problems with the implementation of the marriage which is only carried out by customary Dayak Lundayeh.The type of this research is normative juridical research, namely legal research to find the rule of law, legal principles and legal doctrine to answer the issue of juridical review of customary marriage and its legal consequences.The results of the study indicate that the customary marriage law is a legal rule that regulates the forms of marriage, how to apply, marriage ceremonies and the termination of marriage. Based on the provisions of the regulations stipulated in Law No. 1 of 1974, marriages which are only carried out by Lundayeh customary without religious marriage are not valid, so the marriage cannot be performed either at the Office of Religious Affairs (KUA) for those who are Muslim and the Civil Registry Office (KCS) for those who are not Muslim.The legal consequences of illegitimate marriages that are only carried out traditionally by the Lundayeh Dayak have an impact on the absence of recognition from the State for the marriage carried out, so that in the event of a dispute and dispute arising from the marriage, the State in this case the court cannot resolve the dispute resolution. settlement of marital disputes that are only carried out by custom, by the Lundayeh Dayak community carried out in local wisdom, namely through the customary court session Keywords: Marriage, Adat, Dayak Lundayeh
EFEKTIFITAS LEMBAGA SENTRA PENEGAKAN HUKUM TERPADU (GAKUMDU) DALAM MENEGAKKAN KEADILAN PEMILU
Authors: Agang Muhammad Ilham
Published: November 2021

Abstract Elections are a tangible form of the concept of democracy which is believed to be one form of carrying out government through a "Party" Democracy which should be a party of people who rejoice and have high expectations of the simultaneous election implementation in 2019. Gakumdu as an integrated law enforcement center has an important role in handling election criminal acts. In Article 486 point (1) of Law No. 7 of 2017 explicitly explained the establishment of Gakkumdu intends to equalize the understanding and pattern of handling election criminal acts by the Bawaslu, the Indonesian National Police, and the Attorney General's Office of the Republic of Indonesia. The Gakkumdu members themselves come from the Indonesian National Police and prosecutors from the Indonesian Attorney General's Office.In this paper the central issue is the effectiveness of the integrated Law Enforcement Center (Gakkumdu) in handling every election crime that occurs in each stage of the 2019 General Elections, including seeing what are the problems faced by the Gakkumdu center and what efforts are being made to strengthen the Gakkumdu center.The holding of elections conducted in Indonesia, evidently the procedures and mechanism of elections also influence changes in behavior of both participants, implementers, organizing elections as well as several government and judicial institutions. As for the objects of the formulation of election criminal offenses as formulated in Law Number 7 of 2017 Concerning General Elections, which are classified in line with several qualifications of actions, such as: Criminal acts aimed at everyone, Criminal acts that can be carried out by KPU officers, KPU Province, Regency / City KPU, PPK, PPS and PPLN, made in crimes aimed at implementing the campaign, Criminal acts aimed at election participants proven to receive donations and / or assistance, Criminal acts aimed at state officials / government officials and judicial institutions , Criminal acts aimed at ballot printing companies.
TANGGUNGJAWAB HUKUM USAHA KLINIK KESEHATAN DI KOTA TARAKAN TERHADAP SEGALA RESIKO USAHA
Authors: Febriani Patrisia
Published: November 2021

Abstract This study investigated the legal liability of health clinics in the city of Tarakan for all business risks in terms of the Health Act, the Consumer Protection Act and the Minister of Health’s Regulation on Clinics. As one of many health facilities in Indonesia, clinic is easily accessible by the community. Clinical patients are not only protected by the Health Act but also by the Consumer Protection Act. Clinics as providers of health services are responsible for the actions of health workers to their patients because of the relationship between patients and clinics, which is that the clinic guarantees that every health worker who does his work in the clinic will do his best to heal patients. By basing that the importance of the Informed Concent in medical action, the rights of patients are more respected and protected. The results of the study suggest that clarity of rules and consistency of policies must be increased because they have a huge impact on public trust in the government so that responses to health services will be well coordinated. Doctors / health workers must be more responsible for medical actions that will / have been carried out in the context of fulfilling health services to patients in order to foster an honest and responsible attitude for all health workers who perform health services in the clinic.
EKSISTENSI PERJANJIAN ELEKTRONIK SEBAGAI ALAT BUKTI DALAM HUKUM ACARA PERDATA
Authors: Parulian Leonard
Published: November 2021

ABSTRACTOne form of the Industrial Revolution 4.0 that we can recognize in everyday life is electronic commerce, namely the use of communication networks and computers to carry out business processes that are agreed upon and carried out by the parties and set forth in electronic agreements/contracts. The electronic agreement/contract is carried out on the basis of trust obtained by providing legal recognition of electronic written form in the form of an electronic signature. If there is a broken promise/default by one of the parties entering into an electronic agreement/contract with electronic document evidence signed with electronic signature as evidence, then it must be known carefully the strength of the evidence of electronic agreement on the electronic document and the method of settling the civil dispute.This study aimed to examine and analyze the strength of the evidence of electronic agreements on authentic deeds and patterns of settlement of civil case disputes submitted by the parties with evidence in the form of electronic agreements. The study used a normative juridical method with legal and conceptual approaches and primary and secondary sources of legal material.From the results of the study it can be concluded that the strength of proof of electronic documents signed with electronic signatures is contrary to the strength of proof of authentic deeds made by or in front of public officials in charge where the deed was made or by the authorized public official. In addition, related to the recognition of electronic documents in the judicial system, there is a void in procedural law because it does not regulate electronic documents as evidence but rather electronic documents in the form of decisions or indictments as appeals for cassation requests and reconsideration.Keywords: Electronic Agreement, Electronic Signature, Authentic Deed, Evidence
Entre a seda e a nota
Authors: Gonçalves Rafael Quirino Oliveira , Penaforte Camila Aparecida , Costa Gisele Silva
Published: November 2021

O presente trabalho visa compreender qual o papel das mulheres no tráfico de drogas a partir da base de dados produzida na PIEP[1] pelo CRISP-UFMG[2] através de survey e de entrevistas, em pesquisa intitulada “Amor bandido é chave de cadeia?”. A metodologia usada é a quantitativa, a partir dos dados do survey uma análise das frequências, de modo a identificar quais são os modos de atuação das mulheres presas nas redes de tráfico. Foi tomado como referência teórica os estudos de Lúcia Lamounier Sena (2015) para pensar as dinâmicas das redes de tráfico e os estudos de Manuela Valência e Helena Castro (2018), para pensar as formas de analisar as informações sobre um presídio específico e compreender a atuação feminina na dinâmica do tráfico. Após as análises dos dados chegamos à conclusão que as mulheres se ligam ao tráfico por meio de sua rede social, por convite de amigos, familiares, companheiros e vizinhos. Além disso, o flagrante policial é determinante na construção do crime, ao mesmo tempo em que essas mulheres são detidas com drogas, dinheiro, mas na maioria dos casos sem fazer o uso de armas de fogo, o que demonstra a atuação desligada da violência, e voltada para atendimento de demandas sócio-econômicas que praticamente obrigam essas mulheres a se ligar a uma rede de tráfico de drogas.
[1] Complexo Penitenciário Estevão Pinto.
[2] Centro de Estudos de Criminalidade e Segurança Pública
АНАЛІЗ СТАЛОГО СПОЖИВАННЯ І ВИРОБНИЦТВА В УКРАЇНІ
Authors: Івашура Андрій , Борисенко Оксана , Савченко Микола , Дитиненко Станіслав
Published: November 2021

Цілі сталого розвитку (ЦСР) ООН активізували широко спрямовану екологічну діяльність у всьому світі. У статті основна увага приділяється ЦСР 12 ‒ цілі, яка спрямована на забезпечення сталого споживання і виробництва. Змінення застарілих моделей споживання і виробництва розглядається як основа забезпечення сталості, оскільки вони є основними факторами істотних екологічних, економічних, виробничих і соціальних наслідків. Досягнення ЦСР 12 вимагає серйозних перетворень в Україні, включаючи економічні, виробничі та соціальні процеси. Такі перетворення є величезною проблемою. З іншого боку вони розкривають чудову можливість для сприяння сталому розвитку як для політиків, так і для всіх зацікавлених сторін.
НАБУТІ ПСЕВДОАРТРОЗИ ДОВГИХ ТРУБЧАСТИХ КІСТОК: ПРИЧИНИ УТВОРЕННЯ, ОСОБЛИВОСТІ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ
Authors: Тарасенко Олег , Заборовський В’ячеслав , Горішний Ігор , Заритов Богдан
Published: November 2021

У статті проаналізовано дослідження щодо особливостей причин утворення, лікування та профілактики несправжніх суглобів довгих трубчастих кісток. Визначено найбільш ефективні практики й методики лікування.
ПОШУКИ ЕФЕКТИВНОЇ ОРГАНІЗАЦІЇ СІЛЬСЬКОГОСПОДАРСЬКОГО ВИРОБНИЦТВА НА ПОДІЛЛІ В УМОВАХ КАПІТАЛІЗАЦІЇ НА РУБЕЖІ ХІХ-ХХ СТОЛІТЬ
Authors: Каденюк О.
Published: November 2021

У статті проаналізовано діяльність державних та громадських установ, а також окремих господарств по впровадженню і застосуванню новітніх технологій в систему аграрного виробництва на Поділлі в період реформування аграрних відносин. Акцентовано увагу, що прогрес індивідуального господарства неменшою мірою залежить і від того, як його власник володіє технікою агрикультурних прийомів, наскільки він у змозі з цих й інших елементів останнього створити раціональну комбінацію. Агрикультурний прогрес по суті відбувається шляхом капіталізації дрібного господарства, проте, із збереженням самостійного індивідуального підприємства лише з тією різницею, що вона виливається в форми різноманітних організацій, що задовольняють потреби громадського характеру. Під впливом ринкових умов відбувалися зміни в самій організації селянських господарств. Реорганізація аграрних відносин після впровадження реформи 1906 р. в деякій мірі загострила протистояння двох агрономічних організацій – громадської, з одного боку, й урядової та землевпорядкувальної, що орієнтувалися виключно на одноосібного власника, з іншого, – мала в своїй основі протистояння двох принципів: громадсько-господарського (земського) і приватногосподарського (урядового). Характерною рисою Подільського регіону буле те, що тут домінував аграрний напрям економіки і тому діяльність земських органів щодо питань аграрного розвитку була важливою що в подальшому надавало можливості пошуку нових більш прогресивніших форм організаційно-господарської діяльності на селі.
STATUS OF OXIDANT (MDA) ANTIOXIDANT (SOD) IN FIRST AND THIRD TRIMESTER OF NORMAL PREGNANCY IN TERTIARY CENTER OF CENTRAL INDIA
Authors: Seema Tamrakar , Payasvi Sachdeva , Rashmi Tripathi
Published: November 2021

INTRODUCTION: Pregnancy is associated with high metabolic demand and increased demand for
tissue oxygen. Consequently increased production of reactive oxygen species. This leads in increased
oxidative stress and decreases antioxidant status during gestational age of normal pregnant women.
Aim: Aim of this study was to evaluate the level of oxidant and antioxidant in 1st and 3rd trimester of normal pregnant women.
MATERIAL AND METHODS: The present study included total 150 cases attended ANC Clinic at the department of Gynae
LNMC & J K Hospital was screened for the study. Level of MDA was estimated by Jean et al and SOD was Marklund and
Marklund.
RESULTS: Findings were, that there was signicantly increase in Malondialdehyde levels (p<0.001) and signicantly decrease
in superoxide dismutase activities (P<0.001) in 1st and 3rd trimester of normal pregnant women.
Conclusion: present study concludes that there was difference in oxidative status due to dynamic changes. During pregnancy
oxidative stress is increased and antioxidant decreased that can be fatal to the health of the mother and the fetus. Therefore
antioxidant supplements should be prescribed in early pregnancy to prevent the overwhelming of oxidative stress in pregnant
females.
LEARNERS PREFERENCE TOWARDS ONLINE COURSES- A STUDY
Authors: Anuradha G. , Hema G. A.
Published: November 2021

Online courses are revolutionizing formal education and have opened a new genre of outreach on
cultural and scientic topics. These courses deliver a series of lessons to a web browser or mobile device,
to be conveniently accessed anytime, any place. Nowadays People are interested in enriching their knowledge with the help of
growing technologies, like e-books, mobile library etc. Among them online courses play a vital role. It helps people with
authorized certications, employment etc. without age barrier. For the purpose of study 200 respondents were taken from
Coimbatore city. The tools used for the research are simple percentage analysis, and weighted average score. From the study it
is found that majority of the respondents have indicated their priority for course cost as highly satised feature of the online
course when compared to others. The study suggests that an online education is preferred by individuals who may not be able
to make it for classes in a traditional brick and mortar kind of college due to various reasons, one can gain more professional
knowledge in these online courses if they use it effectively. The educational institutions can also motivate the learners by waving
atleast the part of the fees so that more number of students can be enrolled. The study concluded that, the quality of education
has improved by online courses and even it has become easy for students to refer the content as per their leisure. In the era of
digitalization the scope of online education increases even more and will be benecial for students, professionals and also
institutions.
ITANS: Incremental Task and Network Scheduling for Time-Sensitive Networks
Authors: Arestova Anna , Baron Wojciech
Published: November 2021

Recent trends such as automated driving in the automotive ﬁeld and digitization in factory automation confront designers of real-time systems with new challenges. These challenges have arisen due to the increasing amount of data and an intensiﬁed interconnection of functions. For distributed safety-critical systems, this progression has the impact that the complexity of scheduling tasks with precedence constraints organized in so-called cause-effect chains increases the more data has to be exchanged between tasks and the more functions are involved. Especially when data has to be transmitted over an Ethernet-based communication network, the coordination between the tasks running on different end-devices and the network ﬂows has to be ensured to meet strict end-to-end deadlines. In this work, we present an incremental heuristic approach that computes schedules for distributed and data-dependent cause-effect chains consisting of multi-rate tasks and network ﬂows in time-sensitive networks. On the one hand, we provide a common task model for tasks and network ﬂows. On the other hand, we introduce the concept of earliest and latest start times to speed up the solution discovery process and to discard infeasible solutions at an early stage. Our algorithm is able to solve large problems for synthetic network topologies with randomized data dependencies in a few seconds on average under strict end-to-end deadlines. We have achieved a high success rate for multi-rate cause-effect chains and an even better result for homogeneous or harmonic chains. Our approach also showed low jitter for homogeonous cause-effect chains.
Framwork for fieldwork and documentation in primary Research
Authors: L.A. Isiofia , A.F. Iloeje , H.C. Ajaelu
Published: November 2021

This paper presents an iterative framework for carrying out fieldworks on biodeterioration studies in the built environment with specific reference to the fieldwork on Microbial Colonisation of Building Finishes and Facings in Enugu. The paper discusses the step-by-step preparations prior to and during fieldwork and their importance in fruitful data collection, respondent’s responses and accompanied field interview. It highlights the pros and cons of fieldwork showing reasons why fieldwork is vital in biodeterioration research in the built environment. In doing so, the various stages of the fieldwork are discussed with their implications. At the end of the fieldwork, useful lessons learnt include the essence of digital compass in geolocation, the effect of good first impression during interview, and sourcing of data from government and organizations amongst others.
Sistem Monitoring Kinerja Sub Bagian Operator Scada Menggunakan Agile Development Methods Studi Kasus PT. Cladtek Bi Metal Manufacturing
Authors: Dewi Indah Kusuma , Saputra Randa Amalta
Published: November 2021

PT. Cladtek BI Metal Manufacturing merupakan perusahaan yang bergerak dibidang jasa industri untuk berbagai pekerjaan mengenai material logam, khususnya proses Cladding, Weld Overlay dan Lining pada pipa baja karbon untuk keperluan industri. Pada departement Production memiliki karyawan berjumlah 19 orang terdiri dari 1 orang supervisor, 3 orang foreman dan 15 orang pada sub bagian operator scada. Satu orang foreman membawahi 5 orang karyawan untuk memonitoring kinerja dan pemberian nilai. Namun sangat disayangkan, bahwa performa tim hanya dicatat secara manual pada sebuah buku catatan (log book) oleh setiap foreman (atasan) yang membuat sistem penilaian setiap karyawan menjadi lebih sulit karena tidak adanya visualisasi data yang mempermudahan manajemen mengambil keputusan. Dalam penelitian ini digunaka metode Agile Development untuk mempermudah proses pengambilan spesifikasi sistem dan alur bisnis dan keputusan. Metode agile software development adalah pengembangan perangkat lunak berdasarkan pengembangan iterative dan incremental dimana syarat dan solusi berubah melalui kolaborasi antara selft organizing dan cross functional tim. Sistem ini dibangun dengan Bahasa pemograman Bahasa php, database mysql yang berbasis web dengan tujuan menghasilkan suatu sistem informasi monitoring yang terstruktur dan dapat menampilkan data analisis dalam sebuah dashboard untuk mengendalikan kinerja sub bagian scada di PT. Cladtek BI Metal Manufacturing menggunakan model scrum dan mempermudah penilaian dan kontrol terhadap daftar kerja dan proyek yang masih manual
MAJAS PERSONIFIKASI DAN SIMILE DALAM ANTOLOGI PUISI PEREMPUAN LAUT KARYA SEPULUH PEREMPUAN PENYAIR MADURA
Authors: Anwar M. Shoim , Budi Astuti Sri
Published: November 2021

Sastra adalah seni bahasa. Bahasa diperlukan secara mutlak oleh penyair untukmenuangkan ide, dirangkai secara estetis sehingga menimbulkan efek keindahan.Dalam konteks inilah majas atau gaya bahasa dihadirkan dalam puisi, sepertiyang dilakukan oleh sepuluh perempuan penyair Madura melalui antologi puisiPerempuan Laut (2017). Puisi-puisi yang ada di dalam antologi tersebut adalahkarya Weni Suryandari, Maftuhah Jakfar, Nok Ir, Juwairiyah Mawardy, LindaAutaharu, Tika Suhartatik, Benazir Nafilah, Nurul Ilmi Elbana, Nay Juireng DyahJatiningrat, serta Salama Ilmie. Antologi puisi Perempuan Laut di atas ditelitidengan tujuan untuk menginterpretasi, menganalisis, dan mendeskripsikanpenggunaan majas pesonifikasi dan simile/asosiasi di dalamnya. Penelitian inimenggunakan pendekatan kualitatif. Sumber datanya adalah puisi-puisi yangterdapat dalam antologi tersebut, dikumpulkan melalui kepustakaan, sertadianalisis dengan teknis dialogis antara teks dan konteks. Hasil penelitianmenunjukkan bahwa majas personifikasi dan simile/asosiasi terdapat dalamantologi puisi Perempuan Laut. Semua penyair pada antologi itu menggunakanmajas personifikasi dan simile dengan kadar penggunaan yang berbeda. Tidaksemua puisi menggunakan majas tersebut, namun dipergunakan pada sebagian saja.
HIPOGRAM DAN TRANSFORMASI PADA NOVEL AYAT-AYAT CINTA DAN NOVEL SURGA YANG TAK DIRINDUKAN: KAJIAN INTERTEKSTUAL
Authors: Husnul Kusnaini Sabilla , Pujiastuti Rahayu
Published: November 2021

Penelitian ini bertujuan untuk mendeskripsikan (a) unsur intrinsik Ayat-AyatCinta karya Habiburrahman El Shirazy (b) unsur intrinsik novel Surga yang TakDirindukan karya Asma Nadia; (3) bentuk hipogram dalam hubungan intertekstualantara kedua novel. Penelitian ini menggunakan pendekatan kualitatif. Datapenelitian ini berupa kata, frasa, kalimat dan wacana yang terdapat dalam novelAyat-Ayat Cinta karya Habiburrahman El Shirazy dan Surga yang TakDirindukan karya Asma Nadia yang didalamnya terdapat hal-hal yang berkaitandengan hubungan intertekstual ditinjau dari unsur intrinsiknya. Teknikpengumpulan data yang digunakan adalah teknik dokumentasi. Teknik analisisdata deskriptif kualitatif. Prosedur dalam menganalisis data dilakukan dengan caramemeriksa data yang telah dikumpulkan, mengklasifikasikan dan mengkodekan,menafsirkan, dan menyimpulkan. Keabsahan data menggunakan pengujian teoridan metode. Dari hasil penelitian dan pembahasan yang telah dilakukan diperolehtiga kesimpulan. Pertama, unsur intrinsik Ayat-Ayat Cinta memiliki (a) tokohutama yaitu Fahri, Aisya, dan Maria. Karakter bertindak sebagai protagonis; (b)pengaturan di mana novel ini sebagian besar diatur di negara Mesir; (c) sudutpandang yang digunakan penulis adalah sudut pandang orang pertama sebagaiaktor utama; (d) aliran maju; (e) gaya bahasa yang ditemukan adalahperumpamaan; (f) amanat yang terkandung, selalu ikhlas dalam melakukansesuatu; (g) tema keikhlasan seorang istri. Kedua, unsur intrinsik novel Surgayang Tak Dirindukan memiliki (a) tokoh utama yaitu Pras, Arini, dan Mei Rose;(b) latar tempat novel tersebut berada di kota Bogor; (c) sudut pandang yangdigunakan pengarang, yaitu sudut pandang orang pertama sebagai pemeran utamadan orang ketiga yang mengetahui segalanya; (d) aliran campuran; (e) gayabahasa yang ditemukan adalah ironi; (f) amanat yang terkandung, yaitu kejujuranadalah hal yang paling utama dalam pernikahan; (g) tema dalam novel ini, yaituketulusan seorang istri. Ketiga, bentuk-bentuk hipogram dalam hubunganintertekstual Ayat-Ayat Cinta karya Habiburrahman El Shirazy dengan novelSurga yang tidak ketinggalan karya Asma Nadia, antara lain (a) konversikarakterisasi; (b) modifikasi penokohan, setting dan alur; (c) perluasan sudutpandang; (d) mengetuk tema.
MOTIVASI BELAJAR SISWA PADA PEMBELAJARAN DARING SISWA KELAS VIII-I SMPN 1 TAMAN SIDOARJO
Authors: Rigma Wardani Dhea Oktavia , Muis Tamsil
Published: November 2021

ABSTRAK

 

Berbagai permasalahan yang sering terjadi di sekolah seperti Pembelajaran Daring Di era pandemi seperti penelitian ini bertujuan untuk mendeskripsikan peran guru bimbingan dan konseling dalam pembelajaran siswa secara Daring dan pengawasan terhadap orangtua saat anak nya melakukan pembelajaran secara daring dari rumah. Penelitian ini merupakan penelitian deskriptif kuantitatif. Populasi dalam penelitian ini terdiri dari 61 subjek. Sedangkan sampel penelitian terdiri dari 1 guru bimbingan dan konseling dan 3 siswa yang mengalami motivasi belajar rendah dan 3 Orangtua Siswa yang motivasi.Metode penilitan ini menggunakan deskriptif kuantitatif. Metode penelitian menggunakan angket dan wawancara. Analisis data dalam penelitian ini menggunakan analisis korelasi sederhana untuk mengetahui adanya hubungan antara kedua variabel berdasarkan nilai r (koefisien korelasi). Hasil penelitian yang diperoleh adalah peran guru bimbingan dan konseling terbukti telah mampu mengurangi Motivasi belajar siswa kelas VIII-i di SMPN 1 Taman Sidoarjo, dengan perolehan uji korelasi sederhana 0,980. Adapun peran guru bimbingan dan konseling dalam Motivasi Belajar Siswa SMPN 1 Taman Sidoarjo yaitu guru bimbingan dan konseling selaku wali kelas VIII-i dan Orangtua untuk mengetahui apa penyebab gendala-gendala siswa saat melakukan pembelajaran secara Daring tersebut, kemudian guru bimbingan dan konseling memberikan arahan atau pengetahuan dan wawasan kepada siswa tentang manfaat pembelajaran secara daring.