bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing community health system resilience: lessons learnt during the COVID-19 pandemic in Uganda through the qualitative inquiry of the COVID Task Force
Authors: Saito Kiyoko , Komasawa Makiko , Ssekitoleko Robert , Aung Myo Nyein
Published: November 2023

Objective

This study aimed to explore the elements of a resilient community health system during the COVID-19 pandemic and discuss whether the frameworks described in previous studies can be applied to real-world situations with those who implemented the Community Engagement Strategy, a strategy to make health systems work in their communities during health crises in Uganda.

Methods

Focus group discussions (22 participants in total) were conducted with COVID Task Force members in four districts in Uganda in March 2022. These districts implemented a Community Engagement Strategy to ensure that health systems in their communities continued to function during health scares, and have been evaluated to ensure that the strategies have been implemented.

Results

A thematic analysis was applied. From the results some factors which can enhance the resiliency of community health systems were identified: including health “knowledge,” “communication,” “governance,” and “resources” health. The most important elements changed depending on the phase of the outbreak. VHTs are the key players in the transition from knowledge-and resource-oriented initiatives to communication and governance by community residents.

Conclusion

COVID-19, a new infectious disease, provides lessons for a resilient community health system. First, the health system should be flexible enough to be able to change the elements on which it is focused, and second, VHTs play an important role in the flexibility of the health system. This suggests that it is time to assess whether VHTs are still able to continue their activities after the pandemic is over, and whether the environment, including financial and non-financial support, has improved.
The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis
Authors: Rehman Anees ur , Khattak Mahnoor , Mushtaq Usman , Latif Muhammad , Ahmad Imran , Rasool Muhammad Fawad , Shakeel Sadia , Hayat Khezar , Hussain Rabia , Alhazmi Ghaidaa Ali , Alshomrani Afnan Owedah , Alalawi Mohammed Ibrahim , Alghamdi Saleh , Imam Mohammad Tarique , Almarzoky Abuhussain Safa S. , Khayyat Sarah M. , Haseeb Abdul
Published: November 2023

Background

The existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such as treatment failure and thus, causes disease progression.

Aim

To investigate the impact of DM on the Emergence of MDR-TB and Treatment Failure in TB-DM comorbid patients.

Methodology

The PubMed database was systematically searched until April 03, 2022 (date last searched). Thirty studies met the inclusion criteria and were included in this study after a proper selection process.

Results

Tuberculosis-Diabetes Mellitus patients were at higher risk to develop MDR-TB as compared to TB-non-DM patients (HR 0.81, 95% CI: 0.60–0.96, p < 0.001). Heterogeneity observed among included studies was moderate (I2 = 38%). No significant change was observed in the results after sub-group analysis by study design (HR 0.81, 95% CI: 0.61–0.96, p < 0.000). In the case of treatment failure, TB-DM patients were at higher risk to experience treatment failure rates as compared to TB-non-DM patients (HR 0.46, 95% CI: 0.27–0.67, p < 0.001).

Conclusion

The results showed that DM had a significant impact on the emergence of MDR-TB in TB-diabetes comorbid patients as compared to TB-non-DM patients. DM enhanced the risk of TB treatment failure rates in TB-diabetes patients as compared to TB-non-DM patients. Our study highlights the need for earlier screening of MDR-TB, thorough MDR-TB monitoring, and designing proper and effective treatment strategies to prevent disease progression.
A system science perspective on burn-out: development of an expert-based causal loop diagram
Authors: Barsties Lisa S. , van den Berg Saskia W. , Leone Stephanie S. , Nicolaou Mary , van Oostrom Sandra H.
Published: November 2023

Introduction

Burn-out leads to reduced worker well-being, long-term absenteeism, and high costs for employers and society. Determinants at different levels may affect burn-out in an interrelated and dynamic manner. The aim of the present study was to apply a broader systems perspective by exploring and visualizing the complex system of determinants at different levels (living conditions, working conditions, and societal developments) underlying the prevalence of burn-out in the Netherlands.

Methods

During three group model building (GMB) sessions with in total eight experts on workers’ mental health, a causal loop diagram (CLD) was developed and relevant feedback loops were identified. For the selection of determinants to be included in the CLD a recently published overview of determinants on burn-out at different levels was used. Experts could also add factors that were not listed in the overview.

Results

The final CLD consists of 20 factors and depicts a central position of working conditions. Societal developments (e.g., access to mental health care, size of the working population, rougher social climate, etc.) were mostly located at the outside of the CLD and barely integrated in feedback loops. Several reinforcing feedback loops resulting in an increase of the prevalence of burn-out were identified in which the factors (very) high workload, imbalance between work and private life, and insufficient recovery time play an important role. Also, several balancing loops were found that visualize the crucial role of functional support from supervisors to prevent burn-out among workers.

Discussion

Applying a broader systems perspective, including determinants at different levels, offers new insights into dynamic feedback loops that contribute to the prevalence of burn-out. Supervisors, amongst others, have a considerable impact on the system underlying the high prevalence of burn-out and may therefore contribute to its prevention. Even though societal developments were less integrated in feedback loops, they might be considered drivers of existing feedback loops. The results from this study confirm that determinants at various levels underly the prevalence of burn-out. To be able to address the diversity of determinants underlying a high prevalence of burn-out, a complex system approach can be helpful.
Promoting public skin health through a national continuing medical education project on cosmetic and dermatologic sciences: a 15-year experience
Authors: Li Yiming , Shu Xiaohong , Huo Wei , Wang Xi
Published: November 2023

Background

The developments in cosmetic sciences and technologies have generated a gap between the cosmetics and their users. Users including regular customers, clinicians, industry personnel, researchers, testing agencies, beauty salon workers, and mass media hardly possess the ability to distinguish truth from falsehood. The gap remained as one major reason for inappropriate cosmetics usage, insufficient efficacy, and even cosmetics adverse reactions (CARs).

Methods

Aiming at enhancing the relevant practitioners’ cosmetic and dermatologic sciences, we launched a cosmetic and dermatologic sciences continuing medical education (CME) since 2008. The objective of the current study was to evaluate the effectiveness of the CME. We summarized and analyzed the project for the last 15 years. Meanwhile, an online survey consisted of three parts was performed to evaluate the CME and to collect the trainees’ comments.

Results

A total of 3,923 trainees have participated in the CME project from 2008 to 2022. The trainees included clinicians, industry staffs, biomedical researchers, third-party cosmetics testing staffs, beauty salon staffs, students, and media staffs. The trainees had theory courses on cosmetic and dermatologic sciences, cosmetics DIY practice & video watching, and an optional guided tour during the 4.5-day CME. Eight hundred and twenty-three trainees and 586 control subjects responded to the online survey. The comprehensive test in the second part of the survey demonstrated that compared with the control group, the CME project significantly enhanced the trainees’ perception and knowledge regarding the cosmetics formula sciences, basic dermatologic sciences, cosmetics usage, noninvasive measurements, new advances, CARs, and laws (p = 0.000). Trainees of all occupations ranked “basic dermatologic sciences and skin diseases” as the most significant sections. Trainees of all occupations believed the CME has contributed most in “understand the function & efficacy of cosmetics.” We noticed the occupational variances. Over 97% of trainees were willing to recommend the CME to the others.

Conclusion

The CME project significantly enhanced the trainees’ cosmetic and dermatologic sciences, which bridged the gap between cosmetics and public skin health. This multidisciplinary CME also contributed to establishing an interdisciplinary interaction and cooperation platform for the multiple occupations involved in the public skin health maintenance and promotion.
Prevalence and determinants of health literacy among the adult population of Qatar
Authors: Ahmed Salma , Kehyayan Vahe , Abdou Mariam , Bougmiza Iheb
Published: November 2023

Introduction

Health literacy (HL) is both a direct determinant and a mediator of health outcomes. Research on the prevalence and determinants of HL in terms of its functional, communicative, and critical domains is scarce in the state of Qatar and its surrounding regions. Thus, this study aims to fill the knowledge gap in this area, estimate the levels of functional, communicative, and critical health literacy among the general adult population, and identify its determinants in the state of Qatar.

Methods

An analytical cross-sectional study with a disproportionate stratified random sampling technique was conducted in 2022. A representative sample of phone numbers was obtained from the Cerner database at Hamad Medical Corporation and approached via well-trained data collectors. A socio-demographic and health-relevant factor questionnaire and the validated All Aspects of Health Literacy scale (AAHLS) were used to collect the data on functional, communicative, and critical HL and their determinants. Descriptive analysis, independent sample t-test, ANOVA, and linear regression were used and yielded the outcomes on HL levels as low, adequate, and high in percentages and the HL determinants.

Results

A total of 770 participants were included. The study found that 41.5%, 29.3%, and 29.2% of them have adequate, high, and low overall HL levels consecutively. People who participated in the study are older adult, are of Arabic ethnicity, are of Qatari ethnicity, have a lower level of education, have close relatives with a lower level of education, have a lower income, are non-migrants, are not living within a family, sought medical care within the last week, and who do not know if they have a chronic disease or do not have lower overall HL levels compared to the other groups. After linear regression analysis, only the participant's level of education and “last time sought medical care within last week” variable predict the overall HL score.

Conclusion

Almost half of Qatar's adult population has an adequate HL level, comparable to the HL levels in other regions, despite the limitation in comparison due to variation in context and the HL measurement tools used. The possible determinants are amenable factors to focus on while designing HL interventions and providing healthcare.
The effect of exercise intensity types on the self-rated health status of young-old comorbidities patients: a cross-sectional study in Guangdong, China
Authors: Li Linjin , Dai Fengfeiyue , Zhang Dan
Published: November 2023

Objective

Explore the effect of different types of exercise intensity on the self-rated health status of young-old comorbid patients with cardiovascular disease and metabolic disease, as well as the differences in effect among different genders. Provide more references and suggestions for chronic disease management in older comorbidities patients based on the results of the study.

Methods

A multi-stage stratified cluster random sampling method was used to select older (≥60 years old) comorbidities patients from communities in Guangdong Province as the survey subjects. Using the “Survey Questionnaire on the Current Status and Influencing Factors of older Comorbidities Patients,” face-to-face interviews were conducted with 1,300 old patients. Data from 965 young-old patients (aged 60–74) who simultaneously suffered from cardiovascular and metabolic diseases were selected. Unordered multifactor Logistic regression analysis was used to explore the association between the type of exercise intensity and self-rated health. Stratified analysis was performed based on gender.

Results

The results of unordered multivariate logistic regression analysis showed that compared with young-old comorbidities patients with poor self-rated of health status, young-old comorbidities patients who underwent vigorous-intensity exercise were more likely to have better self-rated of health status (OR = 4.368, 95% CI: 2.491–7.661, p < 0.05). Stratified analysis based on gender showed that for young-old comorbidities male patients, those who engaged in vigorous-intensity exercise were more likely to have better self-rated of health status (OR = 2.924, 95% CI = 1.266–6.751, p < 0.05); for young-old comorbidities female patients, those who were encouraged by their family to exercise (OR = 2.460, 95% CI: 1.143–5.291, p < 0.05), participate in social activities (OR = 6.173, 95% CI: 2.285–16.678, p < 0.05), and engage in vigorous-intensity (OR = 4.232, 95% CI: 1.869–9.583, p < 0.05) or moderate-intensity exercise (OR = 4.555, 95% CI: 1.825–11.368, p < 0.05) were more likely to have better self-rated of health status.

Conclusion

If the physical condition allows, vigorous-intensity exercise has a significant positive effect on the self-rated of health status of young-old comorbidities patients with cardiovascular disease and metabolic disease. Specifically, for young-old comorbidities male patients, those who engage in vigorous-intensity exercise are more likely to self-evaluate their health as good; for young-old comorbidities female patients, both vigorous-intensity and moderate-intensity exercise can improve their self-rated of health status.
Rural industrial convergence, urbanization development, and farmers’ income growth – evidence from the Chinese experience
Authors: Yang Juan , Chen Lingming , Zhang Yadong
Published: November 2023

Farmers’ income growth is a significant social problem, which has a bearing on the building of a moderately prosperous society in an all-round way. The convergence of rural industries based on agricultural development has become a meaningful way to solve the problem. The convergence of rural industries cannot be separated from the construction of urbanisation because the aggregation of population resources and the optimisation of industrial structures need the support of urbanisation. Based on the panel data of 29 provinces in China from 2004 to 2020, this paper makes an empirical study on the interaction between rural industrial agglomeration, urbanisation level, and farmers’ income using the theories of “intermediate role” and “threshold effect.” The results show that rural industrial agglomeration significantly affects farmers’ economic development, among which the eastern, western, and central regions have the most substantial positive effect. The level of urbanisation development is the mediating variable of the impact of rural industrial convergence on farmers’ income growth, which indirectly promotes farmers’ income growth, and the mediating effect is significant. Lastly, the level of urbanisation development is the threshold variable for the impact of rural industrial convergence on farmers’ income growth, and the coefficient of rural industrial convergence on farmers’ income growth is highest when the level of urbanisation is between 0.7960 and 0.8500. Therefore, in order to achieve sustainable growth in farmers’ operating income, wage income and financial transfer income, the country should give full play to the advantages of rural industrial integration, build a modernised industrial system for agriculture, expand the functions of agriculture in the secondary and tertiary sectors, and make good use of the policies that benefit the people in rural industrial development. At the same time, with the opportunity of county urbanisation, a rural industrial development system with the county as the centre of development has been established, guiding the rational flow and effective integration of urban and rural industrial resource elements and realising the integrated development of urbanisation and rural industry. Given the differences in industrial development in the eastern, central and western regions, the State should also promote rural industrial integration policies by stage, region and strategy to raise the level of farmers’ income.
Diversity of antimicrobial resistance, stress resistance, and virulence factors of Salmonella, Shiga toxin-producing Escherichia coli, and Listeria monocytogenes from produce, spices, and tree nuts by whole genome sequencing
Authors: Hu Lijun , Brown Eric W. , Zhang Guodong
Published: November 2023

Introduction

The objective of this study was to analyze antimicrobial resistance (AMR), stress resistance, and virulence factors through whole genome sequencing (WGS) of 192 isolates comprising 164 Salmonella isolates, 8 non-O157 Shiga toxin-producing Escherichia coli (STEC) isolates, and 20 Listeria monocytogenes isolates.

Methods

These isolates were sourced from a national survey conducted between 2010 and 2017, involving 31,322 samples of produce (31 isolates), nuts (43 isolates), and spices (118 isolates).

Results

The findings yielded several key insights: (1) Within all Salmonella isolates studied, the most prevalent Salmonella serotypes included Give, Kentucky, Senftenberg, Mbandaka, Anatum, Newport, and Weltevreden. (2) All eight non-O157 STEC isolates were found to carry the genes blaEC, acrF, and mdtM, while all 20 L. monocytogenes isolates possessed fosX and lin genes. The Salmonella isolates displayed diverse AMR gene profiles, with 3.65% exhibiting multi-drug resistance. (3) Both Salmonella and non-O157 STEC isolates were discovered to carry stress genes associated with acid resistance, but none of the L. monocytogenes isolates carried an acid resistance gene. Salmonella isolates were found to carry multiple metal-resistance genes. The non-O157 STEC isolates universally exhibited acid resistance genes, and 4 out of the 20 L. monocytogenes isolates were equipped with resistance genes against biocides. (4) All of the STEC isolates (100%) carried stx1 and stx2 genes, while none of them carried eae and wyz genes. Most L. monocytogenes isolates were found to contain 29 virulence genes and 1 pathogenicity island. All Salmonella isolates carried SPI-9, but lacked SPI-7, SPI-10, SPI-11, SPI-12, mig-5, prefA, tviA, and viaB genes.

Conclusion

These findings on AMR, stress resistance, and virulence factors among the investigated isolates highlight the potential risks they pose to public health and provide the scientific foundation for the development of preventative and control strategies and guidance pertaining to these major foodborne pathogens.
Comparison of transoral endoscopic thyroidectomy vestibular approach and open conventional thyroidectomy regardıng inflammatory responses, pain, and patient satisfaction: a prospective study
Authors: Ünlü Mehmet Taner , Aygun Nurcihan , Serin Erdinc , Uludag Mehmet
Published: November 2023

Introduction

The application of transoral endoscopic thyroidectomy vestibular approach (TOETVA) is becoming widespread throughout the world. We primarily aimed to evaluate the severity of surgical trauma in TOETVA and conventional open thyroidectomy (COT) regarding the inflammatory response including the comparison of surgical stress markers [interleukin-6 (IL-6), C-reactive protein (CRP), white blood cell (WBC)].

Material and method

This non-randomized prospective study enrolled two groups with 20 patients each: COT group and TOETVA group. Patients aged 18–65 years with benign thyroid disease; with fine needle aspiration biopsy results of Bethesda III, IV or Bethesda V, VI (<1 cm nodule); thyroid volume <50 cm3; nodule diameter <4 cm; female gender without a previous neck, chin, and/or oral surgery; without vocal cord paralysis preoperatively; and patients in euthyroid state were enrolled to the study. Preoperative, postoperative second hour, first day, and second day CRP, WBC, and IL-6 levels were evaluated. Pain intensity was evaluated with the visual analog scale (VAS) score on the 2nd and 12th hour, 1st and 2nd days postoperatively.

Results

All the patients were female and mean age was significantly higher in the COT group. The operative time was significantly longer in the TOETVA group. No significant difference was found between the two groups regarding IL-6 levels. In the TOETVA group, postoperative second hour WBC value (p = 0.044) and first (p = 0.002) and second day (p = 0.005) CRP values were significantly higher. In the TOETVA group, the lower lip and lower chin VAS scores were significantly higher at 2nd and 12th hour, on the first and second days. The anterior neck VAS score was significantly higher in the TOETVA group at the second hour (p = 0.025). General and cosmetic satisfactions were similar at the 15th and 30th days in both groups.

Conclusion

The longer operative time and higher postoperative CRP level and VAS score in the chin and lower lip in the TOETVA group suggested that the method is not a minimally invasive technique compared to COT. However, the presence of similar total complication rates and early postoperative general and esthetic satisfaction that improves over time in both groups suggests that the clinical effect of increased magnitude of systemic inflammatory response in TOETVA might be temporary and acceptable.
Normal variation of clinical mobility of the mandibular symphysis in dogs
Authors: Minei Sergio , Auriemma Edoardo , Bonacini Serena , Kent Michael S. , Gracis Margherita
Published: November 2023

Introduction

The primary objective of this retrospective study was to document the normal variation of clinical mobility of the mandibular symphysis in dogs, and evaluate possible associations with breed, bodyweight, age, sex, and skull morphology. Secondarily, the radiographic appearance of the mandibular symphysis and possible associations with the analyzed data were also evaluated.

Methods

Medical records of dogs that underwent anesthetic procedures for maxillofacial, oral and dental evaluation from April 2015 to December 2021 were included.

Results

567 dogs of 95 different breeds were included, with a total of 695 evaluations. Body weight ranged from 0.8 kg to 79 kg (median 14.4 kg) and age from 3 months to 16 years and 4 months (median 6 years and 9 months). Clinical mobility was evaluated under general anesthesia using a 0 to 3 scale, in lateromedial (LM) and dorsoventral (DV) directions. The symphysis was radiographically classified as being fused or open. The open symphyses were further radiographically divided in having parallel or divergent margins. At the time of the first evaluation DV mobility was 0 in 551 cases (97.2%) and 1 in 16 cases (2.8%). LM mobility was 0 in 401 cases (70.7%), 1 in 148 cases (26.1%) and 2 in 18 cases (3.2%). There was not a significant change in mobility over time for cases examined more than once (P= 0.76). All cases had an intraoral radiographic examination. 83.8% of the radiographs were included in the statistical analysis. Two symphyses (0.4%) were classified as fused and 473 (99.6%) as open, 355 (74.7%) having divergent margins and 118 (24.8%) parallel margins. Logistic regression models exploring factors that affected DV and LM mobility were statistically significant (P < 0.0001; P < 0.0001), with an increase in LM mobility predicting an increase in DV mobility, and vice versa. An increase in age and in bodyweight was associated with a decrease in mobility. There was no statistical difference in clinical mobility across specific breeds or sexes. Increased probability of a divergent symphysis and increased DV mobility was found to be associated with a brachycephalic conformation. The increase in LM mobility was comparatively higher in small brachycephalic breeds compared with larger brachycephalic breed.

Discussion

The majority of the cases showed little to no mobility of the mandibular symphysis and radiographically bony fusion can be rarely seen.
The plantar proximal cortex of the third metatarsal bone shows raised longitudinal ridges at the suspensory ligament enthesis in normal equine isolated limbs – a radiographic, computed tomography, and MRI study
Authors: Dancot Michaël , Joostens Zoë , Audigié Fabrice , Busoni Valeria
Published: November 2023

Introduction

Knowledge of normal radiographic appearance is essential to avoid misinterpretation of radiographs. This study aimed to assess the computed tomographic (CT) appearance of the plantar surface of the proximal metatarsus and evaluate the influence of the radiographic angle on the trabecular/cortical interface of the proximal plantar metatarsal cortex on lateromedial and slightly oblique radiographs.

Methods

Eight hindlimbs were collected from six horses with no known history of lameness and euthanized for reasons unrelated to the study. Limbs underwent computed tomographic (CT) and radiographic examination (dorsoplantar, lateromedial, and slightly oblique radiographic views obtained by angling the beam dorsally and plantarly from the plane used for the lateromedial projection). Standing magnetic resonance (MR) imaging and computed tomography (CT) were used to confirm normalcy. Images were compared side-by-side by two experienced readers.

Results

Limbs were normal at MR imaging. Longitudinal linear ridges were present on the proximal plantar metatarsal surface in all limbs (1–2 sagittal ridges and 1 ridge located at the medial or lateral margin of the suspensory ligament). Longitudinal ridges were positioned facing an adipose-muscular bundle of the suspensory ligament on CT images and were visible as linearly increased opacities on dorsoplantar radiographs. The delineation of the trabecular/cortical interface of the proximal metatarsus changed with radiographic projection and was the sharpest on the plantaro 85° lateral to the dorsomedial oblique view.

Conclusion

The proximal third metatarsal bone shows individual morphological variations, with longitudinal linear ridges that alter the bone homogeneity on dorsoplantar radiographs. An oblique plantaro 85° lateral to the dorsomedial view is suggested to better assess the presence of subcortical sclerosis when proximal suspensory enthesopathy is suspected.
Improvement Effect of Mitotherapy on the Cognitive Ability of Alzheimer’s Disease through NAD+/SIRT1-Mediated Autophagy
Authors: Yang Xiaoxi , Zhou Peiyu , Zhao Zizhen , Li Jingli , Fan Zhigang , Li Xiaorong , Cui Zhihong , Fu Ailing
Published: November 2023

To date, Alzheimer’s disease (AD) has grown to be a predominant health challenge that disturbs the elderly population. Studies have shown that mitochondrial dysfunction is one of the most significant features of AD. Transplantation therapy of healthy mitochondria (mitotherapy), as a novel therapeutic strategy to restore mitochondrial function, is proposed to treat the mitochondria−associated disease. Also, the molecular mechanism of mitotherapy remains unclear. Here, we applied the mitotherapy in AD model mice induced by amyloid−β (Aβ) plaque deposition and suggested that autophagy would be an important mechanism of the mitotherapy. After the healthy mitochondria entered the defective neuronal cells damaged by the misfolded Aβ protein, autophagy was activated through the NAD+−dependent deacetylase sirtuin 1 (SIRT1) signal. The damaged mitochondria and Aβ protein were eliminated by autophagy, which could also decrease the content of radical oxygen species (ROS). Moreover, the levels of brain−derived neurotrophic factor (BDNF) and extracellular−regulated protein kinases (ERK) phosphorylation increased after mitotherapy, which would be beneficial to repair neuronal function. As a result, the cognitive ability of AD animals was ameliorated in a water maze test after the healthy mitochondria were administrated to the mice. The study indicated that mitotherapy would be an effective approach to AD treatment through the mechanism of autophagy activation.
Conclusive Model-Fit Current–Voltage Characteristic Curves with Kink Effects
Authors: Yang Hsin-Chia , Chi Sung-Ching
Published: November 2023

Current–voltage characteristic curves of NFinFET are presented and fitted with modified current–voltage (I-V) formulas, where the modified term in the triode region is demonstrated to be indispensable. In the as-known I-V formula, important parameters need to be determined to make both the measured data and the fitting data as close as possible. These parameters include kN (associated with the sizes of the transistor and mobility), λ (associated with early voltage), and Vth (the threshold voltage). The differences between the measured data and the fitting data vary with the applied source–drain bias, proving that the mobility of the carriers is not consistently constant. On the other hand, a modified formula, called the kink effect factor, is negatively or positively added, simulating solitary heat waves or lattice vibration, which disturb the propagation of carriers and thus influence the source–drain current (IDS). The new statistical standard deviations (δ) are then found to be effectively suppressed as the kink effect is taken into account.
Awareness of Spontaneous Urban Vegetation: Significance of Social Media-Based Public Psychogeography in Promoting Community Climate-Resilient Construction: A Technical Note
Authors: Kong Jie , He Wei , Zheng Yongli , Li Xiaowei
Published: November 2023

Traditional urban green spaces offer numerous benefits to the environment and residents, but their high social resource expenditure on exploitation and maintenance makes them insufficient to face the threats of global climate change and the rapid pace of urbanization, further raising numerous other socio-environmental issues. Spontaneous urban plants have a superior ability to mitigate urban environmental crises due to their ability to maintain urban biodiversity and provide ecological benefits with minor cost and effort of maintenance. However, these values are often overshadowed by their stigmatized image and aesthetic characteristics that are not widely appreciated by the general public. To promote the future utilization of spontaneous plants at the community level, this study explores how, from the perspective of individual psychology, aesthetic appreciation of spontaneous plants can serve as a pivotal element in motivating environmental participation, thereby fostering urban resilience. Public psychogeography, with its focus on the emotional and behavioral interactions between individuals and their urban environments, can be instrumental in promoting community climate resilience by enhancing place attachment and inspiring collective action towards sustainable urban living. Through study, the project conducted by Future Green Studio, based in New York City, raised public interest and awareness based on psychogeography theory and presented a way of using social media posts, not only as a reflection of the public’s aesthetic appreciation of spontaneous urban plants but also as a data collection instrument of their geo-location and ecological properties. The result of the social media engagement activities enabled the establishment of a growing interactive digital open database, covering all of New York City. This database succeeded due to its efficient data collection methods, which resulted in more robust stakeholder engagement as compared to conventional community engagement efforts. The research argues that when residents are empowered to document and learn about their environment, they can become active agents in the creation of sustainable, resilient, and aesthetically enriched urban ecosystems. The success of this initiative offers a replicable model for other cities and demonstrates the potential for collaborative efforts in environmental restoration and education.
Artificial Intelligence Algorithms for Benign vs. Malignant Dermoscopic Skin Lesion Image Classification
Authors: Brutti Francesca , La Rosa Federica La , Lazzeri Linda , Benvenuti Chiara , Bagnoni Giovanni , Massi Daniela , Laurino Marco
Published: November 2023

In recent decades, the incidence of melanoma has grown rapidly. Hence, early diagnosis is crucial to improving clinical outcomes. Here, we propose and compare a classical image analysis-based machine learning method with a deep learning one to automatically classify benign vs. malignant dermoscopic skin lesion images. The same dataset of 25,122 publicly available dermoscopic images was used to train both models, while a disjointed test set of 200 images was used for the evaluation phase. The training dataset was randomly divided into 10 datasets of 19,932 images to obtain an equal distribution between the two classes. By testing both models on the disjoint set, the deep learning-based method returned accuracy of 85.4 ± 3.2% and specificity of 75.5 ± 7.6%, while the machine learning one showed accuracy and specificity of 73.8 ± 1.1% and 44.5 ± 4.7%, respectively. Although both approaches performed well in the validation phase, the convolutional neural network outperformed the ensemble boosted tree classifier on the disjoint test set, showing better generalization ability. The integration of new melanoma detection algorithms with digital dermoscopic devices could enable a faster screening of the population, improve patient management, and achieve better survival rates.
Pharmacogenetic Association between Allelic Variants of the Autophagy-Related Genes and Anti-Vascular Endothelial Growth Factor Treatment Response in Neovascular Age-Related Macular Degeneration
Authors: Kozhevnikova Oyuna S. , Fursova Anzhella Zh. , Derbeneva Anna S. , Nikulich Ida F. , Devyatkin Vasiliy A. , Kolosova Nataliya G.
Published: November 2023

Background: Age-related macular degeneration (AMD) is the leading cause of late-onset blindness in elderly. The occurrence and development of AMD is a multifactorial complex process where autophagy plays an important role. The first-line drugs for neovascular AMD (nAMD) are inhibitors of VEGF, with up to 30% of patients having an incomplete response to treatment. Genetic factors may influence the response to anti-VEGF therapy and explain treatment outcome variability. We aimed to estimate the role of polymorphic markers of the MTOR (rs1064261, rs1057079, rs11121704, rs2295080), SQSTM1 (rs10277), ULK1 (rs11246867, rs3088051), MAP1LC3A (rs73105013) and ATG5 (rs573775) genes in the development of nAMD and the efficacy of anti-VEGF therapy response. Methods: Genotyping by allele-specific PCR was performed in 317 controls and 315 nAMD patients in the Russian population. Of them, 196 treatment-naive nAMD patients underwent three monthly intravitreal injections (IVIs) of aflibercept. Genotypic frequencies were compared with OCT markers of therapy effectiveness and best-corrected visual acuity (BCVA) measures. The main outcomes were the BCVA gain and decrease in central retinal thickness (CRT). Results: MTOR-rs1057079-C, MTOR-rs11121704-C and MTOR-rs2295080-G alleles were associated with an increased risk of nAMD. The BCVA was increased in 117 (59.7%) patients by 10 [5–20] letters, did not changed in 59 (30.1%), and was decreased in 20 (10.2%) patients. ULK1-rs3088051 was associated with BCVA change. Among patients with the TT and CT genotypes for ULK1-rs3088051, an improvement in visual acuity was noted in 67.6% and 53.8% of cases, while in patients with the CC genotype, an increase in BCVA was recorded in 37.5% of cases (p = 0.01). The decrease in CRT was associated with SQSTM1-rs10277 (p = 0.001): it was significantly higher in TT (93 [58–122] mkm) and CT (66 [30–105] mkm) carriers compared to the CC genotype (47 [24–68] mkm). Other SNPs did not show significant associations with the outcome of anti-VEGF treatment. Conclusions: MTOR gene polymorphisms are moderately associated with the risk of nAMD. SQSTM1-rs10277 and ULK1-rs3088051 may influence short-term response to intravitreal anti-VEGF treatment. The results suggest that autophagy could be a target for future drugs to overcome resistance to anti-VEGF therapy.
The Influence of Positive and Negative Aspects of Perfectionism on Psychological Distress in Emerging Adulthood: Exploring the Mediating Role of Self-Compassion
Authors: Koutra Katerina , Mouatsou Chrysi , Psoma Sofia
Published: November 2023

Perfectionism constitutes a multidimensional personality trait. According to the diathesis–stress model, perfectionism may predispose individuals to experience increased psychological distress during stressful periods. Since self-compassion is considered as a protective factor within the context of mental health difficulties, the primary objective of this study was to explore the mediating function of self-compassion in the relationship between positive (i.e., high standards and order) and negative (i.e., discrepancy) aspects of perfectionism and psychological distress among Greek emerging adults. The sample consisted of 410 university students (47.6% males and 52.4% females), with a mean age of 20.61 ± 1.88 years. The Almost Perfect Scale-Revised (APS-R), the Self-Compassion Scale (SCS), and the General Health Questionnaire-28 (GHQ-28) were used to assess perfectionism, self-compassion, and psychological distress, respectively. The results indicated that self-compassion mediated the association between positive and negative aspects of perfectionism and different dimensions of psychological distress (i.e., somatic symptoms, anxiety/insomnia, social dysfunction, and severe depression). Specifically, discrepancy and increased levels of high standards were related to lower levels of self-compassion, thus leading to greater endorsement of psychological distress. In contrast, order was associated with higher levels of self-compassion, thus leading to lower levels of psychological distress. The findings of the present study highlight that self-compassion is an overall important area to examine in nonclinical populations. These findings have implications for the effectiveness of cognitive behavioral therapy (CBT) in enhancing individuals’ self-acceptance and awareness of their perfectionistic tendencies, as well as compassion-focused therapy (CFT) in elevating self-compassion, mindfulness, and overall psychological well-being while reducing psychological distress.
Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms
Authors: Yui Kunio , Imataka George , Shiohama Tadashi
Published: November 2023

The association between the lipid peroxidation product malondialdehyde (MDA)-modified low-density lipoprotein (MDA-LDL) and the pathophysiology of autism spectrum disorder (ASD) is unclear. This association was studied in 17 children with ASD and seven age-matched controls regarding autistic behaviors. Behavioral symptoms were assessed using the Aberrant Behavior Checklist (ABC). To compensate for the small sample size, adaptive Lasso was used to increase the likelihood of accurate prediction, and a coefficient of variation was calculated for suitable variable selection. Plasma MDA-LDL levels were significantly increased, and plasma SOD levels were significantly decreased in addition to significantly increased plasma docosahexaenoic acid (DHA) levels and significantly decreased plasma arachidonic acid (ARA) levels in the 17 subjects with ASD as compared with those of the seven healthy controls. The total ABC scores were significantly higher in the ASD group than in the control group. The results of multiple linear regression and adaptive Lasso analyses revealed an association between increased plasma DHA levels and decreased plasma ARA levels, which were significantly associated with total ABC score and increased plasma MDA-LDL levels. Therefore, an imbalance between plasma DHA and ARA levels induces ferroptosis via lipid peroxidation. Decreased levels of α-linolenic acid and γ-linolenic acid may be connected to the total ABC scores with regard to lipid peroxidation.
An Experimental Study and Adaptability Evaluation of Chain Extender Component in Water Reducer on the Sulfate Corrosion Resistance of Ordinary Concrete
Authors: Wu Bin , Li Xianjun , Meng Xianjie , Zhang Yuanyaun , Zhao Lijun , Zhang Qiang
Published: November 2023

In Shanxi Province, China, concrete foundations of substations are widely exposed to environments with sulfate erosion, which results in severe damage. There are various avenues to enhance sulfate resistance, and one promising approach involves optimizing high-performance water reducers. Chain extender, which is an integral component of a water reducer, serves as a pore-blocking agent to effectively counter sulfate erosion. This study delves into the impact of a chain extender in the water reducer on the sulfate resistance and adaptability of ordinary concrete. The assessment begins with gauging the sensitivity of concrete to sulfate erosion, utilizing a 0–1 scoring method. Comparable conditions are maintained, allowing for a direct comparison between concrete with and without chain extender based on predefined criteria. A score of 1 denotes superior performance, while a score of 0 indicates a poorer performance. Following the evaluation of each criterion, scores are aggregated by the water reducer type, with higher scores signaling superior adaptability. The findings highlight that chain extender enhances the internal porosity of concrete, resulting in a more compact microstructure, heightened impermeability, and improved resistance to sulfate erosion. Its influence on mixture performance, however, is marginal. From an erosion product standpoint, using the semi-immersion method, chemical erosion predominates in the immersion zone, while both chemical and physical erosion are observed in the alternate wet–dry zone. Employing a 0–1 scoring method, Water Reducer 3# (with chain extender) scores 20 points, whereas Water Reducer 3#–1 (without chain extender) scores 4 points. Taking into consideration all factors, the chain extender demonstrates excellent adaptability to ordinary concrete. To validate the effectiveness of the 0–1 scoring method, it is applied to assess fly ash and slag double-blended concrete. Water Reducer 3# (with chain extender) scores 13 points, while Water Reducer 3#–1 (without chain extender) scores 10 points. Taking all aspects into consideration, the chain extender component exhibits commendable adaptability to fly ash and slag double-blended concrete.
Improvement in Sizing Constrained Analog IC via Ts-CPD Algorithm
Authors: Lagos-Eulogio Pedro , Miranda-Romagnoli Pedro , Seck-Tuoh-Mora Juan Carlos , Hernández-Romero Norberto
Published: November 2023

In this work, we propose a variation of the cellular particle swarm optimization algorithm with differential evolution hybridization (CPSO-DE) to include constrained optimization, named Ts-CPD. It is implemented as a kernel of electronic design automation (EDA) tool capable of sizing circuit components considering a single-objective design with restrictions and constraints. The aim is to improve the optimization solutions in the sizing of analog circuits. To evaluate our proposal’s performance, we present the design of three analog circuits: a differential amplifier, a two-stage operational amplifier (op-amp), and a folded cascode operational transconductance amplifier. Numerical simulation results indicate that Ts-CPD can find better solutions, in terms of the design objective and the accomplishment of constraints, than those reported in previous works. The Ts-CPD implementation was performed in Matlab using Ngspice and can be found on GitHub (see Data Availability Statement).
Accuracy of Thoracic Ultrasonography for the Diagnosis of Pediatric Pneumonia: A Systematic Review and Meta-Analysis
Authors: Dong Zhenghao , Shen Cheng , Tang Jinhai , Wang Beinuo , Liao Hu
Published: November 2023

As an emerging imaging technique, thoracic ultrasonography (TUS) is increasingly utilized in the diagnosis of lung diseases in children and newborns, especially in emergency and critical settings. This systematic review aimed to estimate the diagnostic accuracy of TUS in childhood pneumonia. We searched Embase, PubMed, and Web of Science for studies until July 2023 using both TUS and chest radiography (CR) for the diagnosis of pediatric pneumonia. Two researchers independently screened the literature based on the inclusion and exclusion criteria, collected the results, and assessed the risk of bias using the Diagnostic Accuracy Study Quality Assessment (QUADAS) tool. A total of 26 articles met our inclusion criteria and were included in the final analysis, including 22 prospective studies and four retrospective studies. The StataMP 14.0 software was used for the analysis of the study. The overall pooled sensitivity was 0.95 [95% confidence intervals (CI), 0.92–0.97] and the specificity was 0.94 [95% CI, 0.88–0.97], depicting a good diagnostic accuracy. Our results indicated that TUS was an effective imaging modality for detecting pediatric pneumonia. It is a potential alternative to CXR and a follow-up for pediatric pneumonia due to its simplicity, versatility, low cost, and lack of radiation hazards.
Emerging Applications of Nanotechnology in Dentistry
Authors: Malik Shiza , Waheed Yasir
Published: November 2023

Dentistry is a branch of healthcare where nanobiotechnology is reverberating in multiple ways to produce beneficial outcomes. The purpose of this review is to bring into the awareness of the readers the various practical dimensions of the nano-dental complex (nanodentistry) in healthcare and how novelties linked with the field are revolutionizing dentistry. A methodological approach was adopted to collect the latest data on nanotechnology and dentistry from sources, including PubMed, Google Scholar, Scopus, and official websites like the WHO. Nanodentistry is an emerging field in dentistry that involves the use of nanomaterials, nanorobots, and nanotechnology to diagnose, treat, and prevent dental diseases. The results summarize the descriptive analyses of the uses of nanodentistry within orthodontics, preventive dentistry, prosthodontics, restorative dentistry, periodontics, dental surgeries, dental restoration technologies, and other areas of dentistry. The future directions of nano-industries and nano-healthcare have been included to link them with the oral healthcare sector, treatment plans, and improved medical services which could be explored in the future for advanced healthcare regulation. The major limitations to the use of dental nanoproducts are their cost-effectiveness and accessibility, especially in financially constrained countries. These data will help the readers to experience a detailed analysis and comprehensive covering of the diverse achievements of nanodentistry with past analyses, present scenarios, and future implications.