bluuebunny/crossref_metadata_2025 huggingface dataset:
Fc-engineered antibodies with immune effector functions completely abolished
Authors: Wilkinson Ian , Anderson Stephen , Fry Jeremy , Julien Louis Alex , Neville David , Qureshi Omar , Watts Gary , Hale Geoff
Published: December 2021

Elimination of the binding of immunoglobulin Fc to Fc gamma receptors (FcγR) is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been described in the literature but none of them completely eliminates binding to all of the Fcγ receptors. Here we describe a set of novel variants having specific amino acid substitutions in the Fc region at L234 and L235 combined with the substitution G236R. They show no detectable binding to Fcγ receptors or to C1q, are inactive in functional cell-based assays and do not elicit inflammatory cytokine responses. Meanwhile, binding to FcRn, manufacturability, stability and potential for immunogenicity are unaffected. These variants have the potential to improve the safety and efficacy of therapeutic antibodies and Fc fusion proteins.
Prevalence of unrecognized depression and associated factors among medical outpatient department attendees; a cross sectional study
Authors: Lemma Alemu , Mulat Haregewoyin , Nigussie Kabtamu , Getinet Wondale
Published: December 2021

Objectives

To determine the prevalence and associated factors of unrecognized depression among patients who visit non-psychiatric outpatient departments in the University of Gondar specialized teaching hospital. North West Ethiopia.

Methods

An institution-based cross-sectional study was conducted among Medical outpatient departments in the University of Gondar specialized referral hospital from March to April 2019. We collected data through face-to-face interviews. We recruited 314 participants for face-to-face interviews using the systematic random sampling technique. The patient health questionnaire (PHQ-9) was used to measure depression. Coded variables were entered into Epi Info version 7 and exported to SPSS version 20 for analysis. Descriptive statistics and multivariable logistic regression analysis were used. Adjusted odds ratios (AOR) with a 95% confidence interval were used to calculate significance.

Results

A total of 314 participants were interviewed with a response rate of 100%. The prevalence of depression was 15.9% with (95% CI (12.1–20.1)). In the multivariate logistic regression revealed that, able to read and write (AOR = 0.24, 95% CI (0.67–0.84)), secondary education (AOR = 0.34, 95% CI (0.12–0.91)), education in college and university level (AOR = 0.32, 95% CI (0.13–0.78)), poor social support (AOR = 7.78, 95% CI (2.74–22.09)), current cigarette smokers(AOR = 12.65, 95% CI (1.79–89.14)) were associated with depression.

Conclusion

The prevalence of depression among outpatient attendees was high. We recommend an early depression screening be carried out by health professionals.
Study protocol: Strengthening understanding of effective adherence strategies for first-line and second-line antiretroviral therapy (ART) in selected rural and urban communities in South Africa
Authors: Gumede Siphamandla Bonga , de Wit John Benjamin Frank , Venter Willem Daniel Francois , Lalla-Edward Samanta Tresha
Published: December 2021

Multiple factors make adherence to antiretroviral therapy (ART) a complex process. This study aims to describe the barriers and facilitators to adherence for patients receiving first-line and second-line ART, identify different adherence strategies utilized and make recommendations for an improved adherence strategy. This mixed method parallel convergent study will be conducted in seven high volume public health facilities in Gauteng and one in Limpopo province in South Africa. The study consists of four phases; a retrospective secondary data analysis of a large cohort of patients on ART (using TIER.Net, an ART patient and data management system for recording and monitoring patients on ART and tuberculosis (TB)) from seven Johannesburg inner-city public health facilities (Gauteng province); a secondary data analysis of the Intensified Treatment Monitoring Accumulation (ITREMA) trial (a randomized control trial which ran from June 2015 to January 2019) conducted at the Ndlovu Medical Center (Limpopo province); in-depth interviews with people living with Human Immunodeficiency Virus (PLHIV) who are taking ART (in both urban and rural settings); and a systematic review of the impact of treatment adherence interventions for chronic conditions in sub-Saharan Africa. Data will be collected on demographics, socio-economic status, treatment support, retention in care status, disclosure, stigma, clinical markers (CD4 count and viral load (VL)), self-reported adherence information, intrapersonal, and interpersonal factors, community networks, and policy level factors. The systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting and Population, Interventions, Comparisons and Outcomes (PICO) criteria. Analyses will involve tests of association (Chi-square and t-test), thematic analysis (deductive and inductive approaches) and network meta-analysis. Using an integrated multilevel socio-ecological framework this study will describe the factors associated with adherence for PLHIV who are taking first-line or second-line ART. Implementing evidence-based adherence approaches, when taken up, will improve patient’s overall health outcomes. Our study results will provide guidance regarding context-specific intervention strategies to improve ART adherence.
What stands behind the gender gap in entrepreneurship? Untangling the intergenerational parental role
Authors: Zelekha Yaron
Published: December 2021

This research examines the entrepreneurship gender gap by offering an additional novel explanation for the higher share of men in entrepreneurial activity focusing on intergenerational parental role. Participants (N = 1288) aged 18–81, including 259 actual entrepreneurs, completed questionnaires about entrepreneurship tendency, personality traits and socioeconomic background. The gender gap in actual entrepreneurship continues a significant difference in entrepreneurial tendency, which is developed in the first and the second stages of the entrepreneurial trajectory. When women reach the third stage of entrepreneurial development, the execution stage, they have already acquired a self-perception of an incapable and incommensurate entrepreneurial personality. The results indicate that role modeling behavioral channel significantly accounts for the gender gap in entrepreneurial personality. The results suggest that both parents contribute to women’s’ inferior perception of entrepreneurial personality and that their contribution affects all four aspects of the entrepreneurial tendency. It appears that the impact of fathers’ role modeling is larger than that of mothers, and furthermore fathers transfer other entrepreneurial role models from their side in the family.
Cardiovascular safety of celecoxib in rheumatoid arthritis and osteoarthritis patients: A systematic review and meta-analysis
Authors: Cheng Bai-Ru , Chen Jia-Qi , Zhang Xiao-Wen , Gao Qin-Yang , Li Wei-Hong , Yan Li-Jiao , Zhang Yu-Qiao , Wu Chang-Jiang , Xing Jing-Li , Liu Jian-Ping
Published: December 2021

Objective

To assess the cardiovascular safety of celecoxib compared to non-selective non-steroid anti-inflammatory drugs or placebo.

Methods

We included randomized controlled trials of oral celecoxib compared with a non-selective NSAID or placebo in rheumatoid arthritis and osteoarthritis patients. We conducted searches in EMBASE, Cochrane CENTRAL, MEDLINE, China National Knowledge Infrastructure, VIP, Wanfang, and Chinese Biomedical Literature Database. Study selection and data extraction were done by two authors independently. The risk of bias was assessed using Cochrane’s risk-of-bias Tool for Randomized Trials. The effect size was presented as a risk ratio with their 95% confidence interval.

Results

Until July 22nd, 2021, our search identified 6279 records from which, after exclusions, 21 trials were included in the meta-analysis. The overall pooled risk ratio for Antiplatelet Trialists Collaboration cardiovascular events for celecoxib compared with any non-selective non-steroid anti-inflammatory drugs was 0.89 (95% confidence interval: 0.80–1.00). The pooled risk ratio for all-cause mortality for celecoxib compared with non-selective non-steroid anti-inflammatory drugs was 0.81 (95% confidence interval: 0.66–0.98). The cardiovascular mortality rate of celecoxib was lower than non-selective non-steroid anti-inflammatory drugs (risk ratio: 0.75, 95% confidence interval: 0.57–0.99). There was no significant difference between celecoxib and non-selective non-steroid anti-inflammatory drugs or placebo in the risk of other cardiovascular events.

Conclusion

Celecoxib is relatively safe in rheumatoid arthritis and osteoarthritis patients, independent of dose or duration. But it remains uncertain whether this would remain the same in patients treated with aspirin and patients with established cardiovascular diseases.
A rare CTSC mutation in Papillon-Lefèvre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function
Authors: Sanchez Klose Felix P. , Björnsdottir Halla , Dahlstrand Rudin Agnes , Persson Tishana , Khamzeh Arsham , Sundqvist Martina , Thorbert-Mros Sara , Dieckmann Régis , Christenson Karin , Bylund Johan
Published: December 2021

Papillon-Lefèvre Syndrome (PLS) is an autosomal recessive monogenic disease caused by loss-of-function mutations in theCTSCgene, thus preventing the synthesis of the protease Cathepsin C (CTSC) in a proteolytically active form. CTSC is responsible for the activation of the pro-forms of the neutrophil serine proteases (NSPs; Elastase, Proteinase 3 and Cathepsin G), suggesting its involvement in a variety of neutrophil functions. In PLS neutrophils, the lack of CTSC protease activity leads to inactivity of the NSPs. Clinically, PLS is characterized by an early, typically pre-pubertal, onset of severe periodontal pathology and palmoplantar hyperkeratosis. However, PLS is not considered an immune deficiency as patients do not typically suffer from recurrent and severe (bacterial and fungal) infections. In this study we investigated an unusualCTSCmutation in two siblings with PLS, a 503A>G substitution in exon 4 of theCTSCgene, expected to result in an amino acid replacement from tyrosine to cysteine at position 168 of the CTSC protein. Both patients bearing this mutation presented with pronounced periodontal pathology. The characteristics and functions of neutrophils from patients homozygous for the 503A>GCTSCmutation were compared to another previously described PLS mutation (755A>T), and a small cohort of healthy volunteers. Neutrophil lysates from patients with the 503A>G substitution lacked CTSC protein and did not display any CTSC or NSP activity, yet neutrophil counts, morphology, priming, chemotaxis, radical production, and regulation of apoptosis were without any overt signs of alteration. However, NET formation upon PMA-stimulation was found to be severely depressed, but not abolished, in PLS neutrophils.
Bizi-hautuak ertzetatik. Esperientzia agroekologikoen dimentsio subjektiboa trantsizio ekosozialari begira.
Authors: Bergara Eguren Jokin
Published: December 2021

Garapen iraunkorraren gaiak oihartzun mediatiko eta politiko geroz eta zabalagoa hartu duen garaiotan, trantsizio ekosozial demokratiko baterako premia aldarrikatzen da sektore akademiko, sozial eta politiko jakinetatik. Aurrekaririk gabeko erronka zibilizatorioaren aurrean, berrigituraketa materiala bezain garrantzitsu da trantsizio psikokulturalean arreta jartzea. Artikulu honetan elikadura burujabetzaren bidea hautatu duten gazteen azterketa egiten da, hiriko bizimodutik irten eta automugapenaren eta burujabetzaren ideiari jarraiki eratu dituzten esperientzietan arakatuz. Trantsizio ekosizalaren adar subjektiborako ikasgai baliagarriak ateratzea dugu helburu, bizi-esperientzia automugatuek indibiduoaren mailan dituen inpaktuak eta tentsio-puntu ezberdinak ezagutzeko batetik, eta euren jardunari eransten dioten zentzu sozialetan arakatzeko, bestetik. Interes berezia pizten du ekonomia eta subjektibotasun eredu hegemonikoaren aurrean artikulatzen ari diren bizi-praktika kontra-hegemonikoak ikertzeak, erronka sozio-ekologikorako argi puntu batzuekin topo egin dezakegula sinetsita.
Despoblación En Navarra, Nuevas Oportunidades Desde la Economía Social y Solidaria y Feminista
Authors: Barba Areso Izaskun
Published: December 2021

Más de la mitad de toda la población de la Comunidad Foral Navarra tiene como epicentro la capital, Pamplona, y su cuenca. Cada vez menos gente elige vivir en las áreas rurales y éstas se están despoblando. Este fenómeno migratorio tiene sesgo de género. La desigual carga de cuidados y las dificultades que presenta vivir en ciertas zonas de Navarra de cara a la obtención de empleo y de servicios básicos hace que cada vez sea menor la proporción de mujeres jóvenes que viven en pueblos navarros. La economía social y solidaria se presenta como una herramienta de cambio y una oportunidad para la re- ruralización. También como garantía de una vida buena en zonas rurales.
Perceptions of wooden interior product quality – insights on sustainability views among Finnish consumers
Authors: Harju Charlotta , Lähtinen Katja
Published: December 2021

Evaluation of product attributes and the overall quality significantly affect consumer purchasing decisions. Previous studies on wooden products have mostly addressed wood product quality from technical viewpoints, while largely disregarding environmental, social, and economic aspects in the assessments. Therefore, knowledge on how sustainability aspects are evaluated as a feature of wood product quality is narrow. This study investigated consumer perceptions of different quality indicators (i.e., quality cues and attributes) of wooden interior products with a special focus on sustainability and value chain phases. In addition, the connections between consumersâ sociodemographic background and their perceptions of the quality features of wooden interior products were evaluated. The material of the study was based on data gathered in 2018 with a postal survey sent to 1000 people living in Finland with a response rate of 25.6%. As methods of analysis, exploratory factor analysis, the Mann-Whitney U test, and the Kruskall-Wallis test were utilized. The results show that the quality indicators of wooden interior products can be grouped into four factors relating to productsâ environmental friendliness, fit with lifestyle and home design, visual and tactile attractiveness, and technical solidity, which are in multiple ways connected with sustainability. The sociodemographic background of the respondents was found to be linked with consumer scores for those factors. Engaging consumers in sustainable consumption choices requires providing them with information on wooden product value chains that meets their individual needs in relation to their existing knowledge of those issues and individual values.
Early Metallurgy of Eastern Xinjiang
Authors:   Nanjing University, Z. Liangren , Ch. Jianli ,   Peking University, L. Yong ,   Northwest University, Ch. Xien ,   Xinjiang Institute of Cultural Relics and Archaeology, L. Guorui ,   Department of Culture and Tourism Xinjiang Uighur Autonomous Region, K. Rahman ,   Hami Museum, M. Esmayil ,   Hami Museum, Ya. Feng ,   Hami Museum, M. Yingxia ,   Hami Museum
Published: December 2021

This paper examines the form and chemical composition of metal artifacts of three successive cultures of the Hami region. The metal artifacts of the Tianshanbeilu culture are rather diverse in both type and material; body ornaments are dominant, whereas tools and weapons are quantitatively modest. The typological composition and the predominance of body ornaments made of tin bronze, pure copper, and arsenic copper are reminiscent of the Karasuk culture in the Minusinsk Basin and the Siba culture in the Hexi Corridor. Apart from the bulk metal types, there are gold, lead, and antimonial copper. The metal artifacts of the succeeding culture of Yanbulake are morphologically derived from Tianshanbeilu. In the subsequent Heigouliang culture, apart from old types of metal artifacts inherited from the Yanbulake culture, there are a number of new types of artifacts that are morphologically derived from nomadic cultures in the Eurasian steppe. In the cultures of Yanbulake and Heigouliang, the use of tin bronze, arsenic copper, and pure copper prevailed. The source of minerals, especially tin, which is used throughout the three successive cultures, awaits further investigation. Keywords: Xinjiang, Bronze Age, Early Iron Age, metallurgy, Eurasia
Derivatív-ügyletek az Iszlám Bankrendszerben : Derivatives in Islamic Bank System
Authors: Kovács-Szamosi Rita , Kondor Gábor , Varga József
Published: December 2021

Az iszlám terjedésével egyre nagyobb hangsúlyt kapnak az iszlám bankrendszer sajátosságai az európai pénzügyi szektor számára is. Népszerű tévhit az iszlám bankrendszerrel kapcsolatban, hogy a konvencionális bankrendszerben használt derivatív ügyletek nem jutnak szerephez benne. Ennek a cáfolására mutatjuk be, miként jelennek meg a derivatív ügyletek az iszlám bankrendszerben. Tanulmányunkban elsősorban az opciókra és a swap ügyletekre koncentrálunk. A tanulmány során arra is kitérünk, hogy az iszlám bankrendszerben ezek a megoldások milyen gyakorlati formában jelennek meg a pénzügyi közvetítő rendszerben. The importance of Islamic banking structure in the European financial sector is growing year by year with the spread of Islam. About the Islamic banking system there are several popular biases, the most significant is that this system forbid all kind of derivative structures and this block gave the higher stability of the system. The aim of this paper to show how the derivatives appear in this banking system. The main derivative structures what we will describe are the options and swaps. The paper will show how these instruments appear in practice in the financial intermediary system as well.
A remote MQTT-based data monitoring system for energy efficiency in industrial environments
Authors: Balduino Lopes Guilherme , Ferreira Fernandes Junior. Renato
Published: December 2021

The concept of the new industry seeks not only to improve production processes, but also to bring solutions to environmental problems, in addition to reducing resource consumption, while maintaining high yields. This constant search for process optimization has been the main agent in the development of new technologies aimed at improving the performance of industrial production lines. Thus, this article proposes to raise some important concepts of Industry 4.0, and present the development of a remote IoT-based system that, through MQTT and Modbus protocols, will be responsible for monitoring the entire electrical network of an industrial plant, sending its data to the cloud, where it can be monitored and analyzed by the industry management sector or even by an artificial intelligence system, in a simple and effective way, in real time and from anywhere, in order to assist in decision-making focused on energy efficiency.
Parameter N Analysis on the Rational-Talbot Algorithm for Numerical Inversion of Laplace Transform
Authors: Freitas Elisandra , Libardi Calixto George Ricardo , Alves Ferreira Juciara , Denicol do Amaral Rodriguez Bárbara , Prolo Filho João Francisco
Published: December 2021

This article investigates the numerical inversion of the Laplace Transform by the Rational-Talbot method and analyzes the influence on the variation of the free parameter N established by the technique when applied to certain functions. The set of elementary functions, for which the method is tested, has exponential and oscillatory characteristics. Based on the results obtained, it was concluded that the Rational-Talbot method is e cient for the inversion of decreasing exponential functions. At the same time, to perform the inversion process effectively for trigonometric forms, the algorithm requires a greater amount of terms in the sum. For higher values of N, the technique works well. In fact, this is observed in inverting the functions transform, that combine trigonometric and polynomial factors. The method numerical results have a good precision for the treatment of decreasing exponential functions when multiplied by trigonometric functions.
Numerical Simulation of Two-Phase Water-Oil Flow in a Horizontal Pipe Using the Smoothed Particle Hydrodynamics Method
Authors: Carvalho Naim , De Souza Boy Grazione , Pedro Amaral Souto Helio
Published: December 2021

In this work, the numerical code DualPhysics, based on the Lagrangian particle and mesh free method Smoothed Particle Hydrodynamics, has been employed to solve the slightly compressible isothermal two-phase water-oil flow. The continuity and momentum equations are solved, and we used the modified Tait equation of state to determine the pressure. To validate the numerical code, we solved the modified Couette flow of two fluids. As a practical case, we solved the isothermal and two-dimensional two-phase water-oil flow. The mixing of the fluids occurs after passing through a 45 degree Y junction placed at the entrance of the horizontal pipeline. Results showed the potential for using the numerical code, although some modifications and alterations are still necessary to solve practical problems.
Um novo olhar para o tratamento do transtorno depressivo maior: uma revisão dos estudos clínicos realizados com cetamina e escetamina
Authors: Kowalski Layza , Delanogare Eslen , Oliveira Tiago Bittencourt de
Published: December 2021

O tratamento do transtorno depressivo maior consiste, principalmente, na psicoterapia, terapia somática e farmacoterapia. Esta, inclui majoritariamente fármacos que atuam no sistema monoaminérgico. Apesar da sua eficácia terapêutica, esta classe de antidepressivos requer várias semanas para ter seus efeitos terapêuticos, representando um grande desafio para o manejo de paciente com depressão severa e em risco de suicídio. O objetivo do estudo foi revisar os estudos clínicos abordando a molécula de cetamina, e seu enantiômero escetamina, no tratamento do transtorno de depressão maior, a fim de verificar sua eficácia terapêutica, segurança e tolerabilidade. Trata-se de uma revisão integrativa, de estudos que apresentem a cetamina ou escetamina como agente antidepressivo, nas bases de dados U.S. National Library of Medicine e ClinicalTrials.gov. Estudos envolvendo a cetamina intravenosa demonstraram uma eficácia antidepressiva rápida, com pacientes atingindo os critérios de resposta em até um dia após a administração do ativo. Ainda, observou-se também, a rápida diminuição nos níveis de ideação suicida. Entretanto, a fim de facilitar a administração, estudos sugeriram o uso da via intranasal, que se mostrou bem tolerada. Ademais, com evidências propondo uma maior afinidade da escetamina com receptores N-metil-D-aspartato, o isolamento desta permitiu uma maior eficácia terapêutica antidepressiva, além de um prolongamento na manutenção do efeito. Porém, a escetamina provocou efeitos adversos de severidades variadas, incluindo dissociação, sonolência, parestesia, tontura, vertigem, ansiedade, delírio e tendência suicida. Cetamina e escetamina mantém-se como medicamentos de alto risco, devido aos seus efeitos adversos de severidades variadas, incluindo dissociação, sonolência, parestesia, tontura, vertigem, ansiedade, delírio e tendência suicida. Ainda, se faz necessário atentar-se à melhor via de administração para cada caso em particular, com a via intravenosa para pacientes com ideação suicida (pelos rápidos efeitos antidepressivos) e intranasal em casos de depressão moderada.
Caracterização clínica e epidemiológica de pacientes internados em um Centro de Referência em Assistência a Queimados no sul do Brasil
Authors: Araújo Gabriela de Moraes Soares , Romeu Pamella Cristina Folador , Lima Simone Heckler de , Primo Fabian Teixeira , Primo Luciene Smiths , Rodrigues Jamile Lima , Yurgel Virginia Campello , Dora Cristiana Lima
Published: December 2021

Queimaduras são lesões traumáticas com perda da proteção da pele, causadas por agentes externos, tornando indivíduos suscetíveis a infecções, que podem progredir para sepse e óbito. O objetivo deste estudo foi caracterizar o perfil clínico e epidemiológico de pacientes com queimaduras internados em um Centro de Referência no sul do Brasil. Este é um estudo transversal retrospectivo e de natureza quantitativa com dados coletados do sistema do Centro de Referência em Assistência a Queimados da Associação de Caridade Santa Casa do Rio Grande, Rio Grande do Sul, entre janeiro de 2016 e dezembro de 2017. A amostra foi composta por 225 pacientes, sendo a maioria adulta (52,7%), seguida de crianças (30,5%), em maior parte do sexo masculino (64,4%) e procedentes da cidade de Rio Grande (46,5%).  A residência foi o local de ocorrência mais frequente (74,1%). O agente causal mais comum foi de procedência térmica (85,3%), sendo 41,3% dos casos por escaldamento. Observou-se 74,7% dos pacientes com superfície corporal queimada média de 12,3%. As lesões de 2º grau ocorreram em 79,6% dos pacientes. O tratamento tópico mais utilizado foi o composto sulfadiazina de prata (92,8%). Realizou-se desbridamento em 93,3% dos pacientes e enxertia em 5,8%. Complicações secundárias foram registradas em 22,2% dos casos. O tempo médio de internação foi de 14 dias, variando entre 1 e 97, e o principal desfecho foi alta hospitalar (98,7%). Os dados apontam para urgente adoção de medidas de controle e prevenção, especialmente no ambiente doméstico.
Comportamento dos poluentes do ar durante e após lockdown em uma cidade de médio porte
Authors: Tavella Ronan Adler , Salimene Lucas  da Silva , Ulguim Sabrina Morales , Gabriel Romulo Reginato , Da Silva Júnior Flavio Manoel Rodrigues
Published: December 2021

A Pandemia da COVID-19 é, sem dúvida, o maior problema de saúde pública do século, até o momento. Entre as ações sancionadas pelos governos para conter a propagação do vírus estão as medidas de bloqueio e confinamento, conhecidas como lockdown. Vários locais do mundo mostraram melhoria da qualidade do ar decorrente da redução da mobilidade urbana durante os períodos de confinamento. No entanto, os resultados no Brasil ainda foram escassos. O objetivo do estudo foi avaliar o comportamento dos poluentes do ar em um lockdown de curta duração (64 horas) no município de Pelotas, RS. As concentrações de O3, CO, PM2,5 NO2 e SO2 foram medidas durante e após (até 35h) o lockdown por meio de dados de satélite e foram comparadas a média dos sete dias anteriores. Com exceção do NO2, todos os poluentes foram reduzidos durante o período do lockdown e os níveis mantidos mesmo após 30 horas do fim do bloqueio. A redução dos níveis de ozônio durante o lockdown é bastante questionada, em nível mundial, e parece estar relacionada a cidades menos populosas e com baixas concentrações de NO2. O estudo mostrou que um curto período de confinamento é suficiente para reduzir os níveis de poluentes no ar.
Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis
Authors: Hiremath Girish , Sun Lili , Correa Hernan , Acra Sari , Collins Margaret H. , Bonis Peter , Arva Nicoleta C. , Capocelli Kelley E. , Falk Gary W. , King Eileen , Gonsalves Nirmala , Gupta Sandeep K. , Hirano Ikuo , Mukkada Vincent A. , Martin Lisa J. , Putnam Philip E. , Spergel Jonathan M. , Wechsler Joshua B. , Yang Guang-Yu , Aceves Seema S. , Furuta Glenn T. , Rothenberg Marc. E. , Koyama Tatsuki , Dellon Evan S.
Published: December 2021

INTRODUCTION:

Approximately half of esophageal biopsies from patients with eosinophilic esophagitis (EoE) contain inadequate lamina propria, making it impossible to determine the lamina propria fibrosis (LPF). This study aimed to develop and validate a web-based tool to predict LPF in esophageal biopsies with inadequate lamina propria.

METHODS:

Prospectively collected demographic and clinical data and scores for 7 relevant EoE histology scoring system epithelial features from patients with EoE participating in the Consortium of Eosinophilic Gastrointestinal Disease Researchers observational study were used to build the models. Using the least absolute shrinkage and selection operator method, variables strongly associated with LPF were identified. Logistic regression was used to develop models to predict grade and stage of LPF. The grade model was validated using an independent data set.

RESULTS:

Of 284 patients in the discovery data set, median age (quartiles) was 16 (8–31) years, 68.7% were male patients, and 93.4% were White. Age of the patient, basal zone hyperplasia, dyskeratotic epithelial cells, and surface epithelial alteration were associated with presence of LPF. The area under the receiver operating characteristic curve for the grade model was 0.84 (95% confidence interval: 0.80–0.89) and for stage model was 0.79 (95% confidence interval: 0.74–0.84). Our grade model had 82% accuracy in predicting the presence of LPF in an external validation data set.

DISCUSSION:

We developed parsimonious models (grade and stage) to predict presence of LPF in esophageal biopsies with inadequate lamina propria and validated our grade model. Our predictive models can be easily used in the clinical setting to include LPF in clinical decisions and determine its effect on treatment outcomes.
Clinical application of insect-based diet in canine allergic dermatitis
Authors: Lee Kang-Il , Chae Yeon , Yun Taesik , Koo Yoonhoi , Lee Dohee , Kim Hakhyun , So Kyoung-Min , Cho Woo Jae , Kim Ha-Jung , Yang Mhan-Pyo , Kang Byeong-Teck
Published: December 2021

The objective of this study was to evaluate the beneficial effects of the short-term application of insect-based diet in canine allergic dermatitis. Total 19 atopic dogs with concurrent cutaneous adverse food reactions were enrolled and classified into 3 groups. The treatment group (n = 7) was fed insect-based diet, the positive control group (n = 6) was fed salmon-based diet, and the negative control group (n = 6) was fed commercial or homemade diet for 12 weeks. The degree of skin lesions was evaluated based on canine atopic dermatitis extent and severity index (CADESI-4). Additionally, transepidermal water loss (TEWL) and pruritus visual analog scale were evaluated. All indices were evaluated every 4 weeks after the initial administration of hypoallergenic diets. In the treatment group, significant decrease in the CADESI-4 score was observed at 8 weeks compared to the baseline score (p = 0.031). There were significant differences in the CADESI-4 score between the groups at 8 weeks (p = 0.008), 12 weeks (p = 0.012), and TEWL at 12 weeks (p = 0.022). This preliminary result demonstrates the potential hypoallergenicity of an insect-based diet through features that diminish cutaneous lesions and skin barrier dysfunction.
Meningitis y septicemia por Listeria monocytogenes
Authors: Taborda R. P. , Mendosa M. A. , Ramos C. , Manias V. , Lorenz R. , Cristobal S. , Macagno D. , Nardin M. E.
Published: December 2021

Listeria monocytogenes (Lm) es una bacteria gram positiva considerada oportunista. Afecta particularmente a embarazadas, neonatos, ancianos e inmunocomprometidos y puede ocasionar un amplio espectro de manifestaciones clínicas que van desde un síndrome febril a una enfermedad invasiva grave que incluye bacteriemias, sepsis, meningitis y meningoencefalitis.  Se presenta el caso de un paciente adulto masculino con antecedentes de hipertensión, psoriasis, cirrosis y diabetes tipo II insulinodependiente, que ingresó a terapia intensiva del Hospital J. M. Cullen con cuadro febril, astenia, excitación psicomotriz y desorientación temporo espacial asociada a rigidez de nuca.   Se tomaron muestras de sangre, orina y LCR para cultivo,  y se le indicó tratamiento empírico con ceftriaxona y vancomicina. En la coloración de Gram del LCR y de las muestras de hemocultivo se observó la presencia de bacilos positivos. En los cultivos se desarrollaron colonias pequeñas y grisáceas que se identificaron mediante método automatizado Phoenix 100 (BD) y pruebas fenotípicas convencionales como Lmq. Frente a este resultado se rotó la medicación a ampicilina y gentamicina. El paciente evolucionó  favorablemente y una vez finalizado el tratamiento fue dado de alta sin secuelas. Se destaca la importancia de realizar una anamnesis exhaustiva y sospechar bacterias poco frecuentes como Listeria monocytogenes, que pueden originar fallas de tratamiento con la terapia empírica inicial.
Reseña de Queirolo, Graciela. Mujeres que trabajan. Labores femeninas, Estado y sindicatos (Buenos Aires, 1910-1960)
Authors: Saso Débora Natalia
Published: December 2021

El presente texto reseña el libro de Graciela Queirolo Mujeres que trabajan. Labores femeninas, Estado y sindicatos (Buenos Aires, 1910-1960), un trabajo que, abrevando en la historia de las mujeres y la perspectiva de género propone el estudio de experiencias de mujeres trabajadoras desde principios del siglo XX. En tal sentido, se inscribe en una amplia producción historiográfica que indaga sobre la especificidad de la explotación y la opresión femenina en el capitalismo patriarcal.
Salud mental y teletrabajo en tiempos de pandemia
Authors: Rico Prieto José Luis
Published: December 2021

En tiempos de pandemia por COVID-19, el distanciamiento social ha sido y es una respuesta a la amenaza sanitaria recomendada por la Organización Mundial de la Salud. Como consecuencia, se ha incrementado de forma inesperada el teletrabajo siendo, para muchas personas, una experiencia nueva. Si bien puede tener numerosos beneficios, también muestra una serie de desventajas que pueden comprometer la salud física y mental de las personas teletrabajadoras. En la presente comunicación, se revisan diferentes estudios internacionales en torno a las implicaciones que el teletrabajo ha tenido en las personas, así como una serie de recomendaciones generales para promocionar la salud mental durante estas circunstancias.
Penanganan berbagai Tingkat Kelengketan pada Alat gelas di Laboratorium dari Pengaruh Basa kuat Larutan NaOH beserta Ujinya
Authors: Harjanto Sri , Gunawan Indra
Published: December 2021

As PLP (Educational Laboratory Institution) or other laboratory personnel for their daily work, they are very closely related to the tools and materials in the laboratory scope, and cannot be separated from laboratory equipment in the form of instruments or glassware. The problem here is that there are times when we encounter glassware in the scope of a laboratory whose faucet is closed or the faucet cannot be opened because it is sticky, and on average it is used after using NaOH base solution. That is why we are here to try to do a test to find out how much the stickiness of a device made from glass raw materials. By using variable various levels of concentration of NaOH solution with different time periods. As a decay the detergent solution is also used in various levels of concentration and heating. . From the data of the stickiness level test results using variable concentrations of NaOH solution and detergent solution will get the results that with the increasing concentration of NaOH solution, the stickiness will also be stronger. Likewise with the passage of time the longer the NaOH solution comes into contact with materials made of glass, the harder it will become and the stickiness will also be stronger so that it will be more difficult to be released. while on a strong adhesiveness will be more effective when using the immersion method at a temperature of 60-70 ° C.
Evaluasi Penerapan Protokol Kesehatan Pencegahan Penyebaran COVID-19 dalam Pembelajaran Praktik di Laboratorium Program Studi Kebidanan Poso
Authors: Lailatul K Marlina Fitriya , Khuzaifah K
Published: December 2021

Laboratory is one of the important facilities and infrastructure in the learning process, especially Vocational Higher Education which has a larger practical curriculum than theory. The COVID-19 pandemic that is happening in the world makes learning in higher education implemented online. However, vocational colleges in the health sector find it difficult to carry out practical learning without meeting face to face. This study aims to determine the application of health protocols to prevent the spread of COVID-19 in practical learning at the Poso Midwifery Laboratory. This study uses a descriptive method with a qualitative design. The sampling technique was purposive sampling. Data were collected by filling out questionnaires and in-depth interviews with several samples. The results of this study indicate that the application of health protocols to prevent the spread of COVID-19 is quite good with details of the student aspects of 98.6%, laboratory staff aspects of 99.2%, lecturers' aspects of 100%, management aspects of 98.9%, and facility aspect of 96.4.%.
Perbandingan Teknik Penyimpanan Menggunakan Medium Yang Berbeda Terhadap Viabilitas Kapang Colletotrichum capsici dan Prycularia oryzae
Authors: Rasyidah R , Fariani Rini
Published: December 2021

Laboratory of Microbiology which is part of Basic Laboratory System in Faculty of Mathematics and Natural Sciences University of Lambung Mangkurat have commonly used as a place of various activities both science academic practice and research. This laboratory also provides analysis for samples and production. Microbial culture plays important rule in practical science of microorganism. Thus, continuous culture and preservation are highly required. Preservation and re-culture of microbes in the laboratory recently  using short-term preservation and periodic re-culture to a new medium, so it is necessary to conduct research on microbial preservation, especially molds with certain preservation techniques using different media. Colletotrichum capsici and Prycularia oryzae isolates were used in this study. The two molds were stored using different mediums: tapioca, 50% PDB + glycerol, and 50% PDB + liquid paraffin with a preservation period up to 1-3 months. The preserved mold was then cultured onto PDA medium to see its viability. The results of preservation of Colletotrichum capsici for 1-3 months using 3 different types of medium showed that 50% of liquid PDB-paraffin medium had the best viability compared to tapioca medium and 50% PDB-glycerol. Prycularia oryzae preserved for 1-3 months using tapioca medium, 50% PDB-glycerol, and 50% liquid PDB-paraffin cannot grow back.
Trening kompetencji międzykulturowej na podstawie analizy podręcznika do nauki języka szwedzkiego dla uczniów na poziomie średniozaawansowanym Rivstart B1+ B2
Authors: Iwaniak Kamil
Published: December 2021

The aim of the article is to reflect upon the conveying of cultural content in the foreign language classroom that contributes to the development of intercultural competence. It has been attempted to systematize the multitude of aspects which characterizes the use of cultural studies in language classes. It has been done by drawing attention to reasons for taking into consideration this sort of knowledge while preparing the lessons and teaching methods that are in favour of an insightful contact with a cultural content. Attention has been primarily drawn to the coursebook Rivstart B1 +B2 that is intended for intermediate students of Swedish language. The coursebook has been subjected to a comprehensive analysis with regard to the cultural learning.
Blockchain-enabled capabilities in transport operations: an overview of the literature
Authors: Callefi Mario Henrique Bueno Moreira , Tavares Thais Moreira , Ganga Gilberto Miller Devós , Godinho Filho Moacir
Published: December 2021

The blockchain was initially developed for use in the banking sector. However, over time, different areas of knowledge have adopted these technologies, including transportation operations. This use of blockchain in the transport sector is mainly due to the ability of this technology to enable the data generated by these activities to be reliable. In addition to aspects related to data immutability, blockchain enables greater data privacy, as well as making it possible for the data control process to be decentralized. In this sense, it was carried out a systematic literature review (RSL) to identify the general publications panorama on the topic, and to identify the capabilities enabled by the blockchain in the context of transportation operations. RSL has great potential to make it possible to deepen the literature on a given topic. The analysis of the RSL results included the realization of two stages. The first step consisted of a quantitative analysis of data from a sample of 50 articles, to identify this research field about the distribution by journal, year, and author. This first step enabled a general analysis of the field of study on the use of blockchain in transportation. The second stage consisted of a qualitative analysis of the ten most relevant articles in this field of study. In this way, it was possible to understand more about the use of blockchain in transport operations, as well as to identify seven capabilities enabled by the blockchain. These capabilities represent abilities that blockchain technology allows the transport sector today, demonstrating the importance of its use, as well as of study.
Logistics as a competitive advantage in retail organizations
Authors: Besser Freitag Alberto Eduardo , Cunha da Silva Fabiano
Published: December 2021

Retail plays an important role in the trade sector of the Brazilian economy, with net operating revenues of nearly BRL 1.7 trillion and more than 7 million workers in 2018, according to the latest Annual Trade Survey from the Brazilian Institute of Geography and Statistics. The entry of large multinational companies into the Brazilian retail market, where it is worth highlighting Amazon, has negatively impacted the market of Brazilian retail companies, which still use archaic methods and disqualified labor in their operations and processes. Amazon provides better logistics services that directly add value to the quality of products offered through a leaner and more profitable supply chain. Additionally, the behavioral changes brought about by Covid-19 have made consumers more satisfied with online shopping experiences than with visits to physical stores. The increase in internet shopping and the reduction of visits to sales outlets has caused a migration of consumption to digital media, which may generate long-term transformations in the strategies of companies. Thus, the objective of this research is to provide a conceptual proposal of the use of logistics as a competitive advantage in retail organizations, considering the best management practices for the logistics sector. As a research methodology, a systematic literature review was adopted, based on the PRISMA protocol, allowing the identification of 94 records, 12 of which were included in the literature review, due to their adherence to the researched theme. The main contribution of this paper is the development of a conceptual proposal for the use of logistics as a competitive advantage in retail organizations, comprising five aspects: Information Systems, Application of KPIs aligned with the Strategic Objectives of the Organization, Creating Value for Products, Modern Management Concept and, Need for Organizations to recognize the Benefits and Advantages of Logistics.
Cannabis sativa L. chemical compositions as potential plasmodium falciparum dihydrofolate reductase-thymidinesynthase enzyme inhibitors: An in silico study for drug development
Authors: Quan Pham Minh , Huong Le Thi Thuy , Toan Tran Quoc , Hung Nguyen Phi , Nam Pham Hai , Kiet Ngo Tuan , Ha Nguyen Xuan , Le Dang Thi Thanh , An Ton Nu Thuy , Show Pau Loke , Thi Hai Ha Pham
Published: December 2021

This study contributes to anti-malarial research effort by conducting in silico assessment of 125 compounds originated from Cannabis sativa L. against plasmodium falciparum dihydrofolate reductase-thymidinesynthase (pfDHFR-TS) enzyme for potential inhibition activity. Drug-like and pharmacokinetic criteria were used to assess the drug-like properties of the studied compounds. AutoDock4.2.6 and AutoDock Vina software were used to calculate the possible binding pose of the studied compounds to pfDHFR-TS enzyme. The docking procedure was validated using two known inhibitors cycloguanil and WR99210. 65 out of 125 compounds violated no more than 2 of Lipinski’s rule of five and were sorted out as favorable for drug development. Amongst these 65 compounds, pharmacokinetic properties and toxicity evaluation identified 60 compounds that meet the criteria of drug-like properties and were subjected to further docking studies. Docking outcomes identified 10 compounds including compounds 4, 9, 19, 22, 23, 25, 30, 42, 43, and 59 as potential candidates for inhibiting the function of pfDHFR-TS at the active site through hydrogen bonds with Ile14, Asp54, and Ile 164 residues. Compound 9 is considered as the top “hit” with docking energy far more exceeding those of the standard compounds. High correlation coefficient between the docking energy of AutoDock4.2.6 and AutoDock Vina was recorded with the value of R
2 = 0.74.
Evaluating efficacy of different UV-stabilizers/absorbers in reducing UV-degradation of lignin
Authors: Nikafshar Saeid , Nejad Mojgan
Published: December 2021

Susceptibility of wood to UV degradation decreases the service life of wood products outdoors. Organic UV absorbers (UVAs) and hindered amine light stabilizers (HALSs), as well as inorganic UVAs, are added to coatings to improve the UV stability of coated-wood products. Although about 85% of UV radiation is absorbed by lignin in the wood, it is unclear which UV stabilizers can minimize lignin degradation. In this study, the photodegradation of softwood organosolv lignin was monitored over 35 days of UV exposure. Changes in lignin properties were assessed using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and phosphorus-31 nuclear magnetic resonance spectroscopy (31P NMR). It was found that the aromatic rings of lignin underwent significant degradation, resulting in increased glass transition temperature and molecular weight of lignin. Subsequently, 18 different additives were mixed with lignin and exposed to UV irradiation. The analysis of samples before and after UV exposure with FTIR revealed that inorganic UVAs (cerium oxide and zinc oxide) and a mixture of organic UVAs and HALSs (T-479/T-292, T-5248, and T-5333) were the most effective additives in reducing lignin degradation. This study can help coating scientists to formulate more durable transparent exterior wood coatings.
Perspectives on Public History in Colombia
Authors: Pérez Benavides Amada Carolina , Vargas Álvarez Sebastián
Published: December 2021

This article discusses the main characteristics of public history in Colombia, taking into account the challenges of the current political context. From a Latin American perspective of public practices of history, characterized by collaborative research and dialogue between diverse disciplines and knowledge, we analyze some of the experiences developed in Colombia in recent decades. We particularly study the ways in which public history has fostered an open discussion around the armed conflict, the recent peace process, and the social mobilizations of the last years.
Oscillation of nonlinear third-order differential equations with several sublinear neutral terms
Authors: El-Sheikh Mohamed M. A. , Sallam Ragaa , Salem Shaimaa
Published: December 2021

A class of third order differential equations with several sublinear neutral terms of the type

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$$\begin{array}{}
\displaystyle
\bigg( a(t)\Big( b(t)\Big(x(t)+\sum\limits_{j=1}^{n}p_{j}(t)x^{\alpha _{j}}(\tau
_{j}(t))\Big)'\Big)'\bigg)'
+\sum\limits_{i=1}^{m}f_{i}(t,x(\sigma _{i}(t)))=0,\qquad t\geq
t_{0} \gt 0
\end{array}$$

is considered. Some oscillation criteria are presented to improve and complement those in the literature. Two examples are established to illustrate the main results.