bluuebunny/crossref_metadata_2025 huggingface dataset:
Discussion Issues Regarding the Establishment of the Service of Disciplinary Inspectors
Authors: Bakaianova Nana , Pushkar Sergii
Published: July 2023

The article is devoted to changes in the procedure for bringing judges to disciplinary responsibility, which were conditioned by the adoption of the Law of Ukraine "On Amendments to Certain Legislative Acts of Ukraine Regarding the Procedure for the Election (Appointment) of Members of the High Council of Justice and the Activities of Disciplinary Inspectors of the High Council of Justice" dated July 14, 2021 No. 1635-IX and the creation of a new independent structural unit in the secretariat of the High Council of Justice - the service of disciplinary inspectors, which is entrusted with the implementation of the powers of the High Council of Justice to conduct disciplinary proceedings against judges. The purpose of the article is to analyze the legal and organizational aspects of creating a service of disciplinary inspectors. The methodological base of the research consists of a complex of general philosophical, general scientific and general logical methods, as well as general scientific methods of cognition, such as analysis and synthesis, induction and deduction, etc., the totality of which made it possible to achieve a certain level of objectivity, complexity and validity of the conducted research, the reliability of the results obtained. Attention was drawn to some organizational and legal problems of creating this service. The provisions of the draft Law on Amendments to Certain Laws of Ukraine on Resuming Consideration of Cases Concerning the Disciplinary Responsibility of Judges and Ensuring the Work of the Service of Disciplinary Inspectors of the High Council of Justice No. 9261 dated May 2, 2023, aimed at resuming the consideration of cases concerning the disciplinary responsibility of judges and ensuring the work of the service of disciplinary inspectors of the High Council of Justice are analyzed. A point of view was expressed regarding the inadmissibility of further delay in consideration of disciplinary complaints against judges. Proposals for the formation of the service of disciplinary inspectors, determination of the powers of disciplinary inspectors and the head of the service have been provided.
The Drawbacks of Prophecy in Guiding Mankind, A Critique of Islamic Doctrine of Prophethood
Authors: Atrak Hossein
Published: July 2023

The belief in the prophethood and sending prophets by God to guide mankind is one of the common beliefs of divine religions. According to Islamic theologians, divine knowledge and wisdom necessitate the sending of prophets to guide mankind. This study aims to determine the logical challenges associated with this idea, and whether such a thing is expected from God taking into account His attributes. The drawbacks and challenges of prophecy in the guidance of mankind include the logical problem of miracles' indication of prophecy, the inconsistency of miracles with the claims of prophecy, the temporal and linguistic mismatch between prophets and humans, human fallibility, the prophet's interregnum in the world, the problem of exegesis of the scriptures, and the problem of multiplicity of religions and sects. On the contrary, it appears that All-wise God could have used better, simpler, and more effective ways to guide mankind, such as spiritual and instinctive guidance, direct guidance, the sending of a single eternal prophet, and angelic guidance. As a result of the numerous logical and practical flaws in the use of prophecy to guide mankind, the author believes that it seems unlikely and unacceptable that All-wise and All-knowing God has sent prophets for human guidance, and that another justification must be sought for prophecy.
The Suluk of The Salik in the Concept of Seven Stages (Martabat Tujuh) of Abdel Samad al-Palimbani
Authors: Harlis Syukri Alfauzi , Arrasyid Arrasyid
Published: July 2023

This article aims to reveal how the idea of Abdel Samad al-Palimbani on Seven Stages (Martabat Tujuh) is considered controversial by some Muslims. The reason is that this idea is part of the concept of embodiment in the frame of philosophical Sufism. The seven stages essentially are to prove humans as the most perfect creation compared to others. This paper uses the library research method based on primary and secondary sources. This paper attempts to reveal al-Palimbani's ideas related to the seven stages concept. These seven stages discussed Salik's position as caliph on the earth. A Salik is always eager to find the best way to arrive at the paran. The idea of The Seven Stages is to know how close a man is to his Creator. For Salik's is to know their position as being who manifests God’s Tajalli. Unfortunately, such an idea is not fully implemented, even among Islamic thinkers themselves it has been considered heretical and forbidden. This paper showed that the seven stages are the unique condition that must be understood by all Muslims who are concerned with Islamic esoteric studies to know the autentic reality.
Contemporary Qur’anic Lithography in Indonesia: Aesthetic of Reception of the Marble Al-Qur’an Manuscript
Authors: Nurani Shinta , Maulana Luthfi
Published: July 2023

This study discusses the marble manuscripts of the Al-Qur’an and the meaning of its aesthetic reception manuscripts. The type of research is field research with the research locus at Masjid Al-Muhtaram, Kajen, Pekalongan Regency as a place to store the marble stone manuscripts. This study used Wolfgang Iser’s reception theory. Therefore, the results of this study are (1) the marble stone Manuscript of the Qur’an made by Nur Hidayat Siba that started in 2011 until 2021. It has reached 13 juz of Qur’an derived from marble measuring 60 x 90 cm with a marble thickness of 2 cm. It is also written with beautiful khat and gold colour wrapping on every khat. (2) Those manuscript provides three meanings of aesthetic reception. First, the objective meaning of the Qur’an as a holy book must be preserved through beautiful media as a form of appreciation for the greatness of the Qur’an. Second, the expressive meaning is used as a medium of Islamic da’wah, and spirituality increases faith and religious aspects for those who see and read it. Third, the meaning of documentary as a form of habitus to always interact with the Qur’an in everyday life.
Immune status in developing restenosis in patients with occlusive-stenotic lesion of the femoral-popliteal arterial segment after femoral-popliteal bypass surgery
Authors: Lazarenko Victor A. , Bobrovskaya Elena A. , Ivanov Ilia S. , Lipatov Vyacheslav A. , Mishustin Vladimir N. , Godunova Elizaveta I.
Published: July 2023

Objective: to assess the immune status of systemic and local blood flow after femoral-popliteal bypass surgery in patients with and without restenosis. Materials and methods. The analysis of the treatment of 82 patients who underwent femoral-popliteal bypass surgery was carried out. Depending on the condition of the reconstruction zone after 12 months, the patients were divided into two groups: group I - 21 patients without restenosis, group II - 61 patients with the development of restenosis. The analysis of IgA, IgM, IgG, circulating immune complexes (CIC), interleukin (IL)-6, IL-1 in the systemic and local blood flow before and after surgery was performed. Results. In patients with the development of restenosis of the reconstruction zone, the level of IgA in the systemic and IgA, IgM in the local bloodstream was initially lower, the level of CIC, IL-1, IL-6 in the systemic and IgG, IL-1, IL-6 in the local bloodstream was higher, after surgery, the level of IgA in the local bloodstream was lower, higher - IgM in systemic and IL-6 in local blood flow in comparison with patients without restenosis. The correlation between the immune status and the development of restenosis was established: before surgery in the systemic circulation - IgA (r=-0.31, p<0.01), CIC (r=0.39, p<0.001), IL-6 (r=0.25, p<0.05), IL-1 (r=0.26, p<0.05), in the local bloodstream - IgA (r=-0.26, p<0.05), IgM (r=-0.30, p<0.01), IgG (r=0.26, p<0.05), IL-6 (r=0.30, p<0.01), IL-1 (r=0.29, p<0.01); after surgery in the systemic circulation - IgM (r=0.33, p<0.01), in the local - IgA (r=-0.24, p<0.05), IL-6 (r=0.40, p<0.001). The relationship between the degree of chronic arterial insufficiency (r=0.22, p<0.05), the ankle- brachial index after surgery (r=-0.27, p<0.05) with the development of restenosis was revealed. Conclusion. The interrelation of the immune status of the systemic and local blood flow before and after surgery and restenosis in the anastomosis zone after femur-popliteal bypass surgery has been shown. The study of the immune status will make it possible to develop an algorithm for restenosis prevention.
Evaluation of the immunotropic activity of neuropeptide compound Lys-Lys-Arg-Arg-Pro-Gly-Pro in conditions of "social" stress
Authors: Yasenyavskaya Anna L. , Tsibizova Alexandra A. , Andreeva Lyudmila A. , Myasoedov Nikolay F. , Samotrueva Marina A.
Published: July 2023

Objective: to investigate immunotropic activity of the argenine-containing neuropeptide compound Lys-Lys-Arg-Arg-Pro-Gly-Pro in conditions of "social" stress. Material and methods. The study was conducted on mongrel male rats of 6 months of age using a model of "social" stress based on the provision of permanent residence of animals in conditions of sensory contact, as a result of which submissive and aggressive types of behavior were formed. All animals were divided into groups: control I - rats who were in a cage one at a time and received water for injection in an equivalent volume; control II - groups of stressed animals with aggressive and submissive types of behavior; three groups of stressed rats were intraperitoneally injected with Lys-Lys-Arg-Arg-Pro-Gly-Pro at a dose of 100 mcg/kg/day and the comparison drug Imunofan (Arginyl-alpha-aspartyl-lysyl-valyl-thyrosyl-argininum) at an average therapeutic dose of 0.7 mcg/kg/day. The following indicators were evaluated: delayed hypersensitivity reaction index, antibody titer of direct hemagglutination reaction, phagocytic activity of peripheral blood neutrophils, leukocyte formula indicators. Results. The results obtained in the course of this study indicate that the arginine-containing neuropeptide compound Lys-Lys-Arg-Arg-Pro-Gly-Pro contributes to the correction of immune changes that occur against the background of exposure to chronic "social" stress, namely, an increase in the delayed hypersensitivity reaction index, the level of anti-erythrocyte antibodies, the total number of leukocytes and a decrease in phagocytic activity of peripheral blood neutrophils (phagocytic number and phagocytic index), as well as restoration of the percentage ratio of elements of the leukocyte formula. Conclusion. Thus, the study of the immunotropic activity of the argenine-containing neuropeptide compound Lys-Lys-Arg-Arg-Pro-Gly-Pro showed the presence of an immunocorrecting effect on the cellular and humoral links of immunity, which actualizes the need for a detailed study of the immune mechanisms of this compound.
New experimental model of diabetes mellitus for the study of gestational pathology
Authors: Kaplin Anton N.
Published: July 2023

Diabetes mellitus, as one of the most common socially significant diseases, has not lost its relevance for decades. Experimental models for studying this endocrinopathy are of scientific value not only in historical terms, but also greatly enrich modern ideas about various pathophysiological aspects of its course. Objective - to develop and test a new method for inducing diabetes mellitus (DM) with relative insulin deficiency for modeling gestational pathology. Materials and methods. The study was carried out on mature white female rats (30 individuals) of the Wistar line weighing 200-250 g. Using the method of pacreato-slenectomy described in the work, DM with relative insulin deficiency was induced in animals, after which ten female rats with hyperglycemia were transplanted to intact males. Results. Diabetes mellitus in laboratory animals was induced by removing the gastrosplenic part of the pancreas, which made it possible to reproduce the state of rather long-term hyperglycemia (up to 61 days of the experiment) with a high degree of both early and late survival. Female rats selected for the second stage of the experiment were able to become pregnant from intact males and carry offspring, while maintaining stable elevated blood glucose levels throughout the entire gestation period. Conclusion. The experimental model proposed by the authors can provide an opportunity for a long-term study of DM with relative insulin deficiency, as well as testing of new antidiabetic drugs, including against the background of pregnancy.
Serum levels of 25-hydroxyvitamin D and interleukin-1β in Helicobacter pylori-infected women with postmenopausal osteoporosis
Authors: Maylyan Eduard A. , Zhadan Elena S. , Bagriy Andrey E. , Trunova Olga A. , Prokhorov Evgeny V.
Published: July 2023

Dysfunction of the gastrointestinal system in Helicobacter pylori lesions significantly reduces the absorption of not only calcium (Ca), but also vitamin D and other nutrients, the intake of which is critical for bone formation. H. pylory can contribute to the formation of osteoporosis and due to the development of the inflammatory process. The inflammatory process is an important component of the pathogenesis of the above bone disease. Objective: to study of the levels of 25(OH)D and interleukin-1β in blood serum in postmenopausal OP in women with a positive test for antibodies to the Helicobacter pylori CagA antigen. Materials and methods. The study included 250 postmenopausal women, whose indicators (Me [Q1; Q3]) were 62 [56; 68] years, and the duration of the postmenopausal period is 13 [7; 20] years. In all patients, the content of 25(OH)D and interleukin-1β (IL-1β) concentrations were determined in blood serum samples. And total antibodies (IgA, IgM, IgG) to the CagA antigen of the pathogen Helicobacter pylori. Results. In the female group with postmenopausal osteoporosis, the presence of helicobacteriosis is associated with a decrease in the level of 25-hydroxyvitamin D in the blood serum by 14.8% (p=0.045). Serum IL-1β values in postmenopausal women do not depend on H. pylori infection (p>0.05). A negative correlation was found between the values of 25(OH)D and IL-1β in women with osteoporosis and a positive test for total antibodies to H. pylori (rs=-0.25; p<0.05). Conclusion. The results of the study demonstrate that the decrease in vitamin D depends on the infection with Helicobacter pylori in women with postmenopausal osteoporosis (p=0.045). The results of the studies obtained can be used in the diagnostic and treatment-and-prophylactic measures for women in the postmenopausal period.
Development of a method for determining related impurities in a new biologically active compound of cardioprotective action by capillary electrophoresis
Authors: Kompantseva Evgeniya V. , Lutsenko Darya N. , Garcia Ekaterina R. , Ozerov Alexander A. , Dementieva Tatiana M.
Published: July 2023

The original biologically active compound (BAS) N-[2-[4-oxo-3(4H)-quinazolinyl]propionyl]-guanidine (VMA-13-15), which has cardioprotective and neuroprotective activity, was synthesized on the basis of the FSUE at VolgSMU of the Ministry of Health of the Russian Federation. In accordance with the XIV State Pharmacopoeia of the Russian Federation, one of the criteria for quality control of pharmaceutical substances is the indicator "Related Impurities". Based on the synthesis scheme and the structure of the analyzed BAS as a technological impurity, we can assume the presence of the initial compound - - unsubstituted quinazoline-4(3H)-one, due to the possible incomplete flow of the reaction. Objective: the development and validation evaluation of the methodology for determining the technological impurity (quinazoline-4(3H)-one) to include it in the draft regulatory document for the proposed BAS VMA-13-15 as a pharmaceutical substance. Materials and methods. The capillary electrophoretic conditions proposed earlier by us for the determination of the BAS under study were chosen for the analysis, under which the compounds in question are well separated as clear peaks with a migration time of 6.59 min for N-[2-[4-oxo-3(4H)-quinazolinyl]propionyl]-guanidine and 4.37 min for quinazoline-4(3H)-one. Results. As a result of this research, the methodology for determining the indicator "Related Impurities" in BAS VMA-13-15 using capillary electrophoresis system was developed. The developed technique was validated in accordance with the requirements of SF RF of the XIV edition and proved to be acceptable for determination of the identified technological impurity quinazoline-4(3H)-one. Conclusion. The developed technique makes it possible to detect an impurity in the content of 0.1% or more.
Determination of Mexidol in tablets by the method of derivative spectrophotometry
Authors: Kvachakhiya Lekso L. , Shormanov Vladimir K. , Maksina Elena V.
Published: July 2023

Mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) is a drug that exhibits neuroprotective, antihypoxic, anti-ischemic, nootropic, anti-stress and geroprotective effects and can suppress or slow down oxidation reactions. Оbjective: to develop a selective and simple method for assessing the content of mexidol in tablets. Materials and methods. The objects of the study were mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) and Mexidol tablets 0.125 g. Derivative spectrophotometry was used as an analysis method. Results. The ability of mexidol to intensively absorb electromagnetic radiation in the quartz ultraviolet region was revealed. This phenomenon is due to the fact that the analyte molecule contains a number of chromophore groups: a system of conjugated aromatic bonds of the pyridine ring, unpaired electrons at the nitrogen atom, and an enol hydroxyl conjugated with the aromatic system In the region of 292 nm, there is a linear dependence of the derivatives of the 2nd order of the specific absorption coefficient of mexidol on the amount of analyte in the photometric solution (range 2.5-50.0 μg/ml). A calibration graph has been constructed, and its equation has been calculated by the least-squares method. The correlation coefficient exceeds 0.999. The limits of detection and quantification are 1.25 and 2.5 µg/ml, respectively. The technique is characterized by the necessary reproducibility and correctness. The values of the standard deviation and relative standard deviation in the determination of the analyte using the proposed method (n=6; P=0.95) in the tablet mass are 1.16 and 0.012, respectively, in tablets of 0.125 g, 1.32 and 0.013, respectively. Conclusion. A simple and selective method has been developed for estimating the quantitative content of mexidol in 0.125 g tablets based on the calculation of second-order derivatives of spectra.
Assessment of vegetation variation and its response to ENSO and IOD in the semi-arid ecosystem of Western India
Authors: Londhe Digambar S. , Katpatal Yashwant B. , Singh Chandan Kumar , Bokde Neeraj Dhanraj
Published: July 2023

The variation in the vegetation pattern reflects the change in the regional environment. Normalized Difference Vegetation Index (NDVI) data from 2000 to 2022 for the Upper Bhima sub-basin in Western India has been used to identify the response of vegetation to the El Niño-Southern Oscillations (ENSO) and Indian Ocean Dipole (IOD) events. As a novelty, the present study identifies the ENSO-sensitive and IOD-sensitive vegetation areas within the watershed using vegetation mean to difference anomalies. Monthly NDVI anomalies are used to determine sensitive pixels of vegetation using mean monthly NDVI. Local spatial autocorrelation (LISA) is performed to analyze the pattern of the NDVI anomalies and cluster maps are generated. The results of spatial variation show that NDVI is adversely affected in El Niño years. During La Niña years, the percentage area covered by dense vegetation is more than 80%, which is significantly higher than that of El Niño years in the monsoon and post-monsoon periods. Positive IOD years show significantly more sparse vegetation cover than negative IOD years. The results of LISA analysis show that the rainfall shadow zone in the study area has a cluster of negative sensitive pixels even in the monsoon and post-monsoon period except in negative IOD year.
Evaluation and selection of CMIP6 GCMs for long-term hydrological projections based on spatial performance assessment metrics across South Korea
Authors: Huong Nguyen Thi , Kim Yong-Tak , Kwon Hyun-Han
Published: July 2023

The selection of an appropriate subset of Global Climate Models (GCMs) from the Coupled Model Intercomparison Project 6 (CMIP6) for long-term hydrological simulation at the basin scale is a necessity. This study selected high-performing GCMs among 32 available CMIP6 GCMs on the basis of reproducing the observed precipitation over the main watershed in South Korea during the historical period. An integrated selection approach based on four spatial performance assessment metrics was proposed to better estimate changes in precipitation using the simulated GCMs precipitation. Results revealed that the spatial performance over different GCMs could provide an effective means of selecting GCMs for hydrological study over the major river watersheds in South Korea. The four top-ranked GCMs are FIO-ESM-2-0, CESM2-WACCM, CESM2, and CMCC-ESM2, and they overestimated precipitation in South Korea during the historical period, with a bias of 10–25%. However, this study confirmed that a formal bias correction for these GCMs is not recommended prior to model selection, and the ranking of GCMs under the bias correction could be problematic. The proposed approach in this study can be applied to numerous GCMs, climate variables, and other regions to select representative GCMs to reduce the uncertainties in terms of the spatial patterns observed.
Studying the effect of boiler water releasing in rivers on some water properties (Al-Euphrates River at Al-Mussaib thermal power station as case study)'
Authors: Nasir Mohsin J. , Naser Ahmed Sami , Abidalla Wisam Abdulabbas , Ismael Ghosoon Natiq
Published: July 2023

Studying the effect of boiler water released in rivers on some water properties such as density, viscosity was done in this research. Equations of momentum, conversation, turbulence and energy were used with the relation between the temperature and water properties to describe those properties along the study reach. Simplifying of partial equation was done to obtain system of linear equation. Verification of numerical model by conducting comparison of observed data from Euphrates River at Mussaib Thermal Power Station with those computed by the model. The comparison results of density and viscosity show an agreement with using statistical tests such as Chi square and RMSE. The results of the study showed that increasing the bed roughness from 0.04 m to 0.12 m causes a longitudinal retardation of the values of density and viscosity values about (26 and 22%) respectively and vertical advance of these values about (14 and 12% ) respectively. Increasing the water surface slope from (6 cm/km to 12 cm/km) causes a longitudinal advance of density and viscosity values about (19 and 12%) respectively and vertical retardation of these values about (16 and 13%) respectively.
“My funny ABC”
Authors: Sereda Irina Nikolaevna
Published: July 2023

The manual is intended for elementary school students and teachers. It will help them in a playful way to learn phonetic, lexical and grammatical material when learning English.
IN SEARCH OF THE KEYS OF NEW HUMANISM
Authors: Souza Fábio Marques , Miotello Valdemir , Camargo Junior Ivo di
Published: July 2023

In Matrix reloaded a very emblematic figure appears to give meaning to the plot: the Keymaker. In this essay we bring Mikhail Bakhtin as this Keymaker, a man whose philosophy leads us to new ways of thinking and to the constitution of a new human being, full of alterity and surplus of seeing the others.
Thiadiazole and Thiazole Derivatives as Potential Antimicrobial Agents
Authors: Khamitova Аkzhonas , Berillo Dmitriy , Lozynskyi Andrii , Konechnyi Yulian , Mural Dmytro , Georgiyants Victoriya , Lesyk Roman
Published: July 2023

Background:

This review summarizes data on heterocyclic systems with thiadiazole and
thiazole fragments in molecules as promising antimicrobial agents.

Introduction:

Thiadiazole and thiazole backbones are the most favored and well-known heterocycles,
a common and essential feature of various drugs. These scaffolds occupy a central position and
are the main structural components of numerous drugs with a wide spectrum of action. These include
antimicrobial, antituberculous, anti-inflammatory, analgesic, antiepileptic, antiviral, and anticancer
agents.

Method:

The research is based on bibliosemantic and analytical methods using bibliographic and
abstract databases, as well as databases of chemical compounds.

Result:

This review reports on thiadiazole and thiazole derivatives, which have important pharmacological
properties. We are reviewing the structural modifications of various thiadiazole and thiazole
derivatives, more specifically, the antimicrobial activity reported over the last years, as we have
taken this as our main research area. 80 compounds were illustrated, and various derivatives containing
hydrazone bridged thiazole and pyrrole rings, 2-pyridine and 4-pyridine substituted thiazole
derivatives, compounds containing di-, tri- and tetrathiazole moieties, spiro-substituted 4-
thiazolidinone-imidazoline-pyridines were analyzed. Derivatives of 5-heteroarylidene-2,4-
thiazolidinediones, fluoroquinolone-thiadiazole hybrids, and others.

Conclusion:

1,3,4-thiadiazoles and thiazoles are valuable resource for researchers engaged in rational
drug design and development in this area.
WITHDRAWN: The Application of Nanodrug Delivery System with Sequential Drug Release Strategies in Cancer Therapy
Authors: Li Juan , Cao Yongjing , Zhang Xiaojie , An Min , Liu Yanhua
Published: July 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn of the journal "Current Drug Delivery".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

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must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Graph-DTI: A New Model for Drug-target Interaction Prediction Based
on Heterogenous Network Graph Embedding
Authors: Qu Xiaohan , Du Guoxia , Hu Jing , Cai Yongming
Published: July 2023

Background:

In this study, we aimed to develop a new end-to-end learning model
called Graph-Drug-Target Interaction (DTI), which integrates various types of information in the
heterogeneous network data, and to explore automatic learning of the topology-maintaining representations
of drugs and targets, thereby effectively contributing to the prediction of DTI. Precise
predictions of DTI can guide drug discovery and development. Most machine learning algorithms
integrate multiple data sources and combine them with common embedding methods. However,
the relationship between the drugs and target proteins is not well reported. Although some existing
studies have used heterogeneous network graphs for DTI prediction, there are many limitations
in the neighborhood information between the nodes in the heterogeneous network graphs.
We studied the drug-drug interaction (DDI) and DTI from DrugBank Version 3.0, protein–protein
interaction (PPI) from the human protein reference database Release 9, drug structure similarity
from Morgan fingerprints of radius 2 and calculated by RDKit, and protein sequence similarity
from Smith-Waterman score.

Method:

Our study consists of three major components. First, various drugs and target proteins
were integrated, and a heterogeneous network was established based on a series of data
sets. Second, the graph neural networks-inspired graph auto-encoding method was used to extract
high-order structural information from the heterogeneous networks, thereby revealing the
description of nodes (drugs and proteins) and their topological neighbors. Finally, potential
DTI prediction was made, and the obtained samples were sent to the classifier for secondary
classification.

Results:

The performance of Graph-DTI and all baseline methods was evaluated using the sums
of the area under the precision-recall curve (AUPR) and the area under the receiver operating
characteristic curve (AUC). The results indicated that Graph-DTI outperformed the baseline
methods in both performance results.

Conclusion:

Compared with other baseline DTI prediction methods, the results showed that
Graph-DTI had better prediction performance. Additionally, in this study, we effectively classified
drugs corresponding to different targets and vice versa. The above findings showed that
Graph-DTI provided a powerful tool for drug research, development, and repositioning. Graph-
DTI can serve as a drug development and repositioning tool more effectively than previous studies
that did not use heterogeneous network graph embedding.
Novel Gene Signatures for Prostate Cancer Detection: Network Centralitybased
Screening with Experimental Validation
Authors: Zhao Anguo , Zhang Xuefeng , Hu Guang , Wei Xuedong , Huang Yuhua , Hou Jianquan , Lin Yuxin
Published: July 2023

Background:

Prostate cancer (PCa) is a kind of malignant tumor with high incidence among males worldwide. The identification of novel biomarker signatures is, therefore of clinical significance for PCa precision medicine. It has been acknowledged that the breaking of stability and vulnerability in biological network provides important clues for cancer biomarker discovery.

Methods:

In this study, a bioinformatics model by characterizing the centrality of nodes in PCa-specific protein-protein interaction (PPI) network was proposed and applied to identify novel gene signatures for PCa detection. Compared with traditional methods, this model integrated degree, closeness and betweenness centrality as the criterion for Hub gene prioritization. The identified biomarkers were validated based on receiver-operating characteristic evaluation, qRT-PCR experimental analysis and literature-guided functional survey.

Results:

Four genes, i.e., MYOF, RBFOX3, OCLN, and CDKN1C, were screened with average AUC ranging from 0.79 to 0.87 in the predicted and validated datasets for PCa diagnosis. Among them, MYOF, RBFOX3, and CDKN1C were observed to be down-regulated whereas OCLN was over-expressed in PCa groups. The in vitro qRT-PCR experiment using cell line samples convinced the potential of identified genes as novel biomarkers for PCa detection. Biological process and pathway enrichment analysis suggested the underlying role of identified biomarkers in mediating PCa-related genes and pathways including TGF-β, Hippo, MAPK signaling during PCa occurrence and progression.

Conclusion:

Novel gene signatures were screened as candidate biomarkers for PCa detection based on topological characterization of PCa-specific PPI network. More clinical validation using human samples will be performed in future work.
STAT3 Signaling Axis and Tamoxifen in Breast Cancer: A Promising Target for
Treatment Resistance
Authors: Zamanian Mohammad Yasin , Golmohammadi Maryam , Alalak Ali , Kamiab Zahra , Obaid Rasha , Ramírez-Coronel Andrés Alexis , Hjazi Ahmed , Abosaooda Munther , Mustafa Yasser , Heidari Mahsa , Verma Amita , Nazari Yashar , Bazmandegan Gholamreza
Published: July 2023

Signal transducers and activators of transcription 3 (STAT 3) have been proposed to be responsible for
breast cancer development. Moreover, evidence depicted that upregulation of STAT3 is responsible for angiogenesis,
metastasis, and chemo-resistance of breast cancer. Tamoxifen (TAM) resistance is a major concern in breast cancer
management which is mediated by numerous signaling pathways such as STAT3. Therefore, STAT3 targeting inhibitors
would be beneficial in breast cancer treatment. The information on the topic in this review was gathered from
scientific databases such as PubMed, Scopus, Google Scholar, and ScienceDirect. The present review highlights
STAT3 signaling axis discoveries and TAM targeting STAT3 in breast cancer. Based on the results of this study, we
found that following prolonged TAM treatment, STAT3 showed overexpression and resulted in drug resistance. Moreover,
it was concluded that STAT3 plays an important role in breast cancer stem cells, which correlated with TAM
resistance.
Two-Dimensional MXene-Based Functional Composites for Photocatalysts:
Current Status and Perspectives
Authors: Chen Yingchun , Liang Mengjie , Zhang Chi
Published: July 2023

MXenes, as novel two-dimensional (2D) transition metal carbides, nitrides or carbonitrides, have excellent metal conductivity, high carrier mobility, and surface-terminated groups regulated band structure. It can be thus used as a cocatalyst in photocatalytic systems to improve the photocatalytic properties. This review represented recent research progress on the controllable construction of MXene-based functional composites with zero-dimensional (0D), one-dimensional (1D), 2D, and three-dimensional (3D) semiconductor photocatalysts and their applications for photocatalysts. Extensive information related to 2D MXene-Based composites for photocatalysts and their associated patents were collected. The construction methods and photocatalytic enhancement mechanisms of 2D MXene-based composite photocatalysts were given. Due to their excellent physical and chemical properties, 2D MXene composites have been widely used in pollutant removal, hydrogen production, CO2 reduction, and nitrogen fixation. Through the construction of 2D MXene-based functional composite photocatalysts with novel structures and excellent performance, it provides a new perspective for the design and construction of high-efficiency photocatalysts. The future research directions of MXene-based composite photocatalysts was proposed.
Pathophysiology, Current Therapeutic Options, Vaccine Candidates, and Drug
Targets for Human Brucellosis
Authors: Pritam Manisha , Kumar Rajnish
Published: July 2023

Brucellosis is an infectious disease caused by different species of Brucella bacteria. It is also known as Malta fever, one of the neglected diseases
that can cause infection in both animals and humans. Although human-to-human infection is rare, it can spread through the inhalation of airborne
agents, and if left untreated, it can lead to serious health complications. In this review, we aim to highlight the pathophysiology, prevention,
epidemiology, mitigation, cure, targets for drug development, and vaccine development against human brucellosis. Human brucellosis is mainly
caused by consuming unpasteurized milk or dairy products, uncooked meat, and contact with infected animals. Human brucellosis outbreaks are
mainly associated with developing and low- to middle-income countries. Brucella is present all over the world, and only some of the regions are at
high risk, including Asia, Africa, Eastern Europe, Mexico, South and Central America, the Caribbean, the Mediterranean Basin, and the Middle
East. Because of intracellular survival, inhibition of apoptosis, and immune evasion, Brucella can survive and multiply inside the host cell, which
can cause chronic disease. By using proteomics approaches, several new drug targets were reported for human brucellosis that can be used for the
development of novel drugs. We can also develop an efficient vaccine against human brucellosis by exploring previously reported vaccine
candidates against animal brucellosis. The information provided through this review will facilitate research to control and cure human brucellosis
and its complicated symptoms.
Propolis, Plant Sources and Antimicrobial Activity: An Overview
Authors: Soltani Amina , Benhanifia Mokhtar
Published: July 2023

Antibiotic resistance was described soon after the discovery of penicillin by Fleming. In recent years, there has been an increasing interest in developing alternatives to solve this problem.
Propolis «Bee glue» has been used by humans in folk medicine since ancient times, it is a natural resinous mixture produced by honeybees (Apis mellifera) from collected parts of plants. Many studies reported that the phytochemical composition of Bee glue is complex and highly variable and depends on plant species, thus, determining their biological and pharmacological properties. Propolis is considered a potential an-ti-microbial agent that overcomes the phenomenon of antibiotic resistance. Therefore, its combination with standard antibiotics could be a very useful strategy in the medical field, to treat infectious diseases.
Влияние условий оптического возбуждения на спектральные и временные характеристики излучения двумерных фотонных кристаллов с Ge(Si)-наноостровками
Authors: Яблонский А.Н. , Юрасов Д.В. , Захаров В.Е. , Перетокин А.В. , Степихова М.В. , Шалеев М.В. , Шенгуров Д.В. , Родякина Е.Е. , Смагина Ж.В. , Дьяков С.А. , Новиков А.В.
Published: July 2023

The effect of optical excitation conditions on the spectral and temporal characteristics of the radiation from two-dimensional photonic crystals based on the structures with self-assembled Ge(Si) nanoislands has been studied. It was shown that one of the main factors effecting the spectral position and shape of
photoluminescence lines, as well as the photoluminescence kinetics of photonic crystals with Ge(Si) nanoislands, along with the mode structure of the photonic crystal, are the local heating of the samples and the concentration of nonequilibrium charge carriers created by the absorption of the pumping radiation.
Влияние давления мышьяка при заращивании квантовых точек InAs тонким низкотемпературным слоем GaAs на их оптические свойства
Authors: Балакирев С.В. , Кириченко Д.В. , Комаров С.Д. , Драгунова А.С. , Черненко Н.Е. , Шандыба Н.А. , Крыжановская Н.В. , Жуков А.Е. , Солодовник М.С.
Published: July 2023

This paper presents the results of the experimental studies of InAs quantum dot overgrowth by a low-temperature GaAs layer at different arsenic vapor pressures. It is revealed that a threefold decrease in the arsenic pressure at a fixed deposition rate of the capping layer leads to a change in the shape of the photoluminescence spectrum of quantum dots with one maximum at the level of 1.19 eV to the shape of the spectrum with two low-energy contributions at the levels of 1.08 and 1.15 eV. Based on the analysis of the power dependences of the photoluminescence spectra, it is found that the low-energy contributions of the photoluminescence of quantum dots overgrown at a low arsenic pressure correspond to the ground-state emission two groups of quantum dots with different average sizes formed during mass transfer in the “quantum dot – wetting layer – matrix” system.
Энергетическая структура мультиэкситонов в квантовых проволоках с продольным ограничивающим потенциалом
Authors: Кумар Рави , Теленков М.П. , Митягин Ю.А.
Published: July 2023

The energy spectra of many-particle excitons in quantum wires with a longitudinal confining potential providing a size-quantization energy comparable with the characteristic energy of the Coulomb interaction of charge carriers are calculated. It has been found that, upon excitation of one of the charge carriers, the binding energy of a multiexciton decreases by a value several times greater than the quantum confinement energy.
Adverse events of replacement therapy in children with growth hormone deficiency
Authors: Aryayev M. , Senkivska L.
Published: July 2023

Background. The purpose was to analyze and summarize the accumulated short-term and long-term safety data in children with growth hormone deficiency (GHD) treated using recombіnant human growth hormone (rhGH) based on the results of a physical examination, assessment of vital signs, laboratory parameters, and follow-up. Materials and methods. The study was conducted at the Odesa Regional Children’s Clinical Hospital from 2012 to 2022, with 92 children treated for GHD using rhGH at an average dose of 0.033 mg/kg/day. The evaluation of the safety of this therapy was based on assessing the incidence of adverse events (AEs) as a negative consequence of medical care. We analyzed both short-term and long-term outcomes. Results. When studying the short-term safety of rhGH therapy according to physical examination data, AEs were found in 18 (19.57 %) children, including intracranial hypertension (1), arthralgia (1), prepubertal gynecomastia (1), anemia (3), manifestation of latent adrenal insufficiency (3), latent thyroid insufficiency (2), impaired glucose tolerance (7). 20.6 (7.0 ÷ 34.2) % of patients with unacceptable adherence to rhGH therapy reported painful injections compared to 4.3 (–1.6 ÷ 10.2) % of children with acceptable compliance (χ2 = 5.15; р = 0.02). None of the children experienced serious adverse events such as scoliosis progression, slipped capital femoral epiphysis, edema, and impaired vital functions. AEs in terms of hematological and biochemical parameters were usually transient, often in combination with intercurrent diseases, and were not associated with rhGH. In long-term safety, there was no association between rhGH therapy and the risk of cancer, cardiac, and cerebrovascular diseases. Still, three children (3.26 %) had type 2 diabetes, with overweight in one case and obesity in two. Conclusions. In general, in the short-term context, rhGH therapy for children with GHD is safe. The pain at the injection site is a clinically significant AE as a cognitive emotional barrier to the adherence to rhGH therapy. From the point of view of the long-term safety of rhGH therapy, the fact that type 2 diabetes was detected in 3 (3.26 %) children with increased body weight and obesity is essential.
The Attention Economy in the New Media Era: Challenges and Recommendations
Authors: Jingtong Zheng
Published: July 2023

In the era of big data and algorithm-driven platforms, information has become a valuable commodity, and success in Internet communication and publicity hinges on capturing attention effectively. The attention economy, a central concept in the realm of new media, emphasizes the competition among platforms to attract and engage audiences. This article presents a situational analysis of the development of the new media market and the societal implications of the attention economy. Drawing from this analysis, the paper provides recommendations for both enterprises and individuals to navigate the attention economy successfully. While the attention economy offers numerous benefits to society, it also raises certain challenges that necessitate collective efforts for resolution.
LIFESTYLE-RELATED PREDICTORS OF TESTOSTERONE DEFICIENCY AMONG MALE PATIENTS WITH CHRONIC SPINAL CORD INJURY
Authors: Sharma Anil Kumar , Prakash Om , Urmila Mahala , Ritika Parihar
Published: July 2023

Objectives: In the current study, the author evaluated the prevalence of low testosterone and its independent predictors among male patients with chronic spinal cord injury (SCI).
Design: This descriptive type of observational study was conducted in the department of PMR at SMS Medical College.
Methods: In this cross-sectional study, 120 patients with chronic SCI were recruited, serum testosterone levels were assessed, and testosterone levels below 300 ng/dL were considered low. The following eight suspected independent predictors for low testosterone levels were assessed: age, body mass index (BMI), nicotine users, total lipid profile, level of injury, American Spinal Injury Association (ASIA) impairment scale, leisure-time physical activity (LTPA) score (h/week) via LTPA questionnaire, and aging male’s symptom (AMS) score via AMS questionnaire.
Results: The mean age of the patients was 33.2±7.8 years. Patients with low testosterone exhibited a significant association with dorsal SCI (70.9%), motor complete (ASIA A and B) SCI (76.4%), nicotine use (65.5%), a higher triglyceride (TG) level (168.5 mg/dL), a higher total lipid level (712.9 mg/dL), and a higher AMS score (35.7). Patients with low testosterone were found to be engaged in lower (9.4 h/week) LTPA. A significant negative correlation of total testosterone levels was observed with TG (r=−0.184, p=0.044), total lipid (r=−0.570, p<0.001), BMI (r=−0.504, p<0.001), and AMS scores (r=−0.549, p<0.001). Whereas there was a significant positive correlation observed between total testosterone and LTPA (r=0.380, p<0.001).
Conclusion: The prevalence of low testosterone is found at 45.8%, and BMI, LPTA, AMS, and total lipids are identified as independent predictors of low testosterone.
DESCRIPTIVE STUDY ON SUICIDE ATTEMPTERS ATTENDING CONSULTATION-LIAISON PSYCHIATRY SERVICES AT A TERTIARY CARE HOSPITAL
Authors: K Pugazhendhi , BHARATHI K  , BALAMURUGAN K  , J Ravishankar
Published: July 2023

Aims and Objectives: Suicidal attempts are more common than suicides. Knowing the sociodemographic profile of patients, psychological causes, and mode of attempts helps gain insight into suicide attempts. This study aims to describe the profile of suicide attempters attending consultation-liaison psychiatry services.
Methods: This was a prospective observational study conducted at the psychiatry clinic, Government Villupuram Medical College and Hospital, Tamil Nadu on suicide attempters between June 2019 and November 2019. Beck’s suicide intent scale was used to assess the level of intent.
Results: Of the total of 610 study individuals, the mean age was 28.73±11.73 years, majority were females (57.70%), suicide attempt was more in young adults (59.18%), more in married (64.91%), more in those with secondary school education (54.91%), and more in skilled workers and homemakers. Poison consumption was the most common mode of suicide attempt (92.62%), predominantly insecticides. Alcohol intoxication (39.14%) was the most common psychiatric derangement. Interpersonal conflict (63.44%) was the most common precipitating factor. About 74.92% had less suicidal intent.
Conclusion: Marital conflicts, interpersonal conflicts, and alcohol-related illnesses were the major precipitating factors. Restriction of the availability of alcohol and toxic insecticides can help reduce the incidence of suicide attempts and deaths. The promotion of healthy coping mechanisms and community-based mental care activities can help in suicide prevention.