bluuebunny/crossref_metadata_2025 huggingface dataset:
Le Goût du vin. Créativité institutionnelle, appellations et culture du vin en Suisse et en Nouvelle-Zélande
Authors: Laesslé Melaine-Noé
Published: March 2021

Après m’avoir accordé un long entretien, un vigneron-encaveur valaisan me raccompagne puis prend congé sur ces mots : « Il y en a qui sont là pour faire du vin, d’autres pour faire de l’argent ». Bien que lapidaire, cette formule résume bien les conflits de valeurs propres au monde du vin, des rivalités qui se traduisent inévitablement par des jeux de pouvoir. Au-delà des terroirs et des cépages, le goût du vin doit beaucoup aux choix politiques locaux, bien plus que ce que notre seul palais pourrait nous laisser penser. Les appellations de vin sont des ressources communes susceptibles de générer de nombreuses formes de valeurs, économiques bien sûr, mais également culturelles, symboliques et sensorielles. Dans cet ouvrage, l’auteur remonte le fil des jeux d’acteurs, des rapports de force et des mécanismes institutionnels à l’oeuvre dans les deux principaux cantons viticoles de Suisse (Vaud et Valais) ainsi que dans deux régions de Nouvelle-Zélande. Il propose des outils conceptuels novateurs qui ont la particularité d’accorder autant de place au goût et aux aspects symboliques du vin qu’à ses enjeux économiques. L’étude des cas de Féchy, du Lavaux, de Fully et de Chamoson en Suisse ainsi que celles des cas néo-zélandais (Marlborough et Central Otago) mettent en évidence les stratégies qu’adoptent les acteurs locaux pour différencier leur appellation et pour en obtenir les formes de valeurs qu’ils convoitent. L’analyse comparée permet en conclusion d’identifier les éléments généraux favorables au succès de l’action collective qui façonne les appellations de vin, ce qui amène l’auteur à proposer des pistes de recommandations à l’intention des acteurs suisses.
Estilo de pensamiento y liderazgo para una gestión empresarial eficaz
Authors: Linares-Cazola José , Espinoza Antonio , Gutierrez-Chilca Randall
Published: March 2021

INTRODUCCIÓN. Esta investigación analiza la relación entre estilos de pensamiento y estilos de liderazgo que ejercen las pymes y como esta relación, afecta la eficacia de la gestión. Las pymes se han analizado de distintas formas, jamás desde la manera de pensar de los emprendedores y como esta dimensión se relaciona con su modo de liderar y a su vez como afecta la gestión en las organizaciones. OBJETIVO. Determinar la relación de los estilos de pensamientos con los estilos de liderazgo y como esta a su vez determina el nivel de gestión de las micro, pequeñas y medianas empresas. MÉTODO. La investigación se ha desarrollado bajo un enfoque cuantitativo. Se han analizado 382 organizaciones cuya gestión es relativamente positiva. RESULTADOS. Se ha comprobado la relación directa de los estilos de pensamiento con los estilos de liderazgo, además que esta relación genera un nivel de gestión poco efectivo. Se ha detectado cuatro estilos de pensamiento predominantes. DISCUSIÓN Y CONCLUSIONES. Es importante analizar el problema de las Pymes desde otro enfoque, no en el sentido estructural sino bajo el análisis crítico de la conducta y comportamiento de los emprendedores para explicar sus resultados.
COMPARISON OF SCHOOL BASED-COOPERATIVE PROBLEM BASED LEARNING (SB-CPBL) AND CONVENTIONAL TEACHING ON STUDENTS’ ATTITUDES TOWARDS SCIENCE
Authors: Musalamani Wael , Yasin Ruhizan Mohammad , Osman Kamisah
Published: March 2021

This study examined the effect of the SB-CPBL on Jordanian 8th-grade students’ attitude towards science. A quantitative quasi-experimental design with a non-equivalent control group was employed in this study. 120 8th-graders, divided into two groups, were involved in this study. Two groups (60 students, 30 males, and 30 females) were designated as the experimental group; they used the SB-CPBL module for six weeks, while two groups (60 students, 30 males, and 30 females) were designated as the control group and taught conventionally. The validity and reliability of the measurements used, comprising four sub-scales with 40-items, were already robust. The statistical comparison between the groups showed a significant improvement in the SB-CPBL students’ attitudes towards learning science compared with their conventionally-taught counterparts. The findings also confirmed the insignificant effects of gender vis-à-vis attitudes towards science. The results concluded the effectiveness of SB-CPBL approach in improving students’ attitudes towards science in school settings. Keywords: cooperative learning, cooperative problem-based learning, problem-based learning, students’ attitudes towards science
A NEW ASSESSMENT OF HOCS-ORIENTED LEARNING FOR STUDENTS’ HIGHER-ORDER THINKING ABILITIES BY MARZANO’S TAXONOMY
Authors: Su King-Dow
Published: March 2021

This research focuses on students’ higher-order cognitive skill (HOCS)-oriented learning to construct effective hierarchical thinking abilities in their chemical particulate nature of matter. For in-depth knowledge and profound understanding, this research deals with students’ positive developments towards HOCS with a special guidance to Marzanos’ taxonomy. The methodology starts from the retrieval and comprehension of HOCS-centered assessment instrument to students’ analysis and knowledge utilization of transitional performances. 326 participants were assigned to take natural science curriculum in 2019 academic year. With the help of 7 scholars’ implements, the importance of content validity and inter-rate reliability were constructed through instrument developments of students’ HOCS performances. All research results indicated that more distributions of HOCS thinking abilities reached up to the target response of 38.0% analysis task and 27.30% knowledge utilization in Marzanos’ spectrum. This research is beneficial and advantageous that students will be capable of additional learning efficiency in their multiple interactive engagements with academic resources and suggestions from instructors, researchers, and science educators. Key words: HOCS-oriented learning, knowledge utilization, Marzanos’ taxonomy, particulate nature of matter
PREFERRED CHEMISTRY CURRICULUM PERSPECTIVE: TEACHERS’ PERCEPTION OF LOWER-SECONDARY SCHOOL TEXTBOOKS
Authors: Vojíř Karel , Rusek Martin
Published: March 2021

The (written) state curriculum is one of the cornerstones influencing education. Its specifically mediated by textbooks. In an open textbook market, the influence of the state curriculum is limited, and the main responsibility passes to individual schools or teachers. In order to understand education from the potential attainment of curriculum goals’ point of view, it is necessary to pay attention to the teachers’ textbook preferences. This research was focused on the field of lower-secondary chemistry education in Czechia, with special attention paid to the textbooks in use, their choice, and teachers’ perception of them. The data were gathered using a questionnaire distributed to a representative sample of 387 lower-secondary school chemistry teachers. The results showed that teachers favor traditional chemistry teaching conceptions. Most teachers stated that textbooks play a vital role for them when preparing lessons and new textbooks are mostly chosen by the most experienced teachers. Most teachers also expressed their preference for textbooks which contain subject-matter ordered according to the structure of chemistry, i.e. not adjusted for learners, as well as textbooks dominantly orientated towards the transmissive approach to education. Regarding the teachers’ perception of textbooks, potential limits were identified in implementing innovations in (chemical) education. Keywords: chemistry textbooks, lower-secondary school science education, teachers' teaching conception
Pre-diabetes and Type 2 Diabetes Status in Overweight and Obese Children in a Tertiary Care Hospital of Bangladesh
Authors: Hossain Monira , Begum Suraiya , Rahman Shahana A
Published: March 2021

Introduction: Obesity in childhood is associated with many co-morbid conditions; one of them is alteration of glucose metabolism.

Materials and Methods:This cross-sectional study was conducted among 100 overweight and obese children aged 5-16 years to determine the status of pre-diabetes (IFG and IGT) and type 2 diabetes mellitus (T2DM), attending the OPD, BSMMU, Dhaka. All overweight/obese children were included according to BMI for age and sex using CDC growth chart. Children taking steroid for any cause or having any endocrine disorder or syndrome was excluded from the study. Anthropometry and blood pressure measurement were done and skin manifestations of insulin resistance were looked for. Fasting lipid profile and oral glucose tolerance test (OGTT) was done for each child.

Result: Among the studied children 62% were male and 38% female, 77% were obese and 23% were over weight. Evidence of insulin resistance were found among most of the children and most common evidence was dyslipidemia (80%) followed by acanthosis nigricans(76%). Skin manifestation of polycystic ovary syndrome (PCOS) was found in 3% of children. Impaired fasting glucose (IFG) was found in 4% and Impaired Glucose Tolerance (IGT) was found in 7% of children among them 4% had both IGT and IFT. No child was found diabetic in this study.

Conclusion:Altered glucose metabolism was present in overweight and obese children of our children, so screening is recommended.

Bangladesh J Child Health 2020; VOL 44 (3) :143-147
Bronchiolitis: State-of-the-art
Authors: Kabir ARM Luthful
Published: March 2021

The commonest cause of respiratory distress in young children is bronchiolitis. Bronchiolitis is an acute viral lower respiratory tract infection which predominantly affects children up to two years of age. It is a seasonal disease, dominating winter months, with a peak over 6 to 8 weeks around the winter solstice. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children who present with the typical clinical features of viral upper respiratory infection progressing to the lower respiratory tract. Management is largely supportive, focusing on maintaining oxygenation and hydration. Evidence suggest no benefit from bronchodilator or corticosteroid use in infants with first episode of bronchiolitis. Evidence for other treatment such as hypertonic saline is evolving. In case of severe bronchiolitis, there is some role for high-flow nasal cannula and continuous positive airway pressure use.

Bangladesh J Child Health 2020; VOL 44 (3) :161-169
Abstract from Current Literatures vol.44(3)
Authors: Editor -
Published: March 2021

Abstract not available

Bangladesh J Child Health 2020; VOL 44 (3) :188-189
Lesão renal aguda na COVID-19 e abordagem multiprofissional
Authors: Matos Ana Caroline Gusmão de , Andrade Thiago Vaz de , Noronha Nathalia Costa Macedo , Lima Thayná Bezerra , Nascimento Carmem Isaura Salles do , Santos Alícia Calinne Melo , Santana Valéria Soares de Jesus , Maynard Luana Godinho , Jesus Carla Viviane Freitas de
Published: March 2021

Objetivo: Identificar a relação da COVID-19 com a lesão renal aguda, bem como o papel da abordagem multiprofissional nesse cenário. Metodologia: Trata-se de uma revisão narrativa realizada a partir das bases de dados PubMed, SciELO e LILACS, utilizando os descritores “COVID-19” e “Acute Kidney Injury”. Foram incluídos estudos originais publicados disponíveis na íntegra para leitura, publicados nos últimos 5 anos, nos idiomas português, inglês e/ou espanhol. Foram excluídos artigos veterinários, os que avaliaram pacientes com doenças renais crônicas prévias à infecção pela COVID-19 ou transplantados, além de resumos isolados e editoriais. Resultados: O SARS-CoV-2 invade células humanas a partir da enzima conversora de angiotensina 2 e serino-proteases transmembrana tipo 2, ocasionando resposta inflamatória sistêmica por tempestade de citocinas, efeito citotrópico direto induzido por vírus e necrose tubular aguda, devido a falha de múltiplos órgãos e choque. A rabdomiólise contribui para esse quadro. Clinicamente, os pacientes com lesão renal aguda e COVID-19 podem ser apresentar com sintomas geniturinários, diarreia, proteinúria, hematúria e alterações de ureia e creatinina. A abordagem ao paciente nefrológico no contexto pandêmico envolve reforço de medidas preventivas ao novo vírus, gestão de saúde eficaz e colaboração entre médicos e enfermeiros de diversas especialidades, em especial intensivistas e nefrologistas. Conclusão: A infecção pelo SARS-CoV-2 pode ocasionar lesão renal aguda por toxicidade viral direta ou desregulação de mecanismos imunológicos. O quadro clínico nesses casos é marcado por sintomas de falência renal e infecção. A atuação sinérgica de equipe de saúde multiprofissional e gestores de saúde é fundamental nesse cenário.
Monumento ao Cristo Redentor, em Itaporanga – PB: uma análise acerca da necessidade de preservação do patrimônio histórico e cultural nacional
Authors: Caiana Clarice Ribeiro Alves , Araújo Ânderson Firmino de , Brasileiro Samuel Hilário , Silva Matheus Matos Ferreira , Sousa Júnior Joselúcio Barbosa de
Published: March 2021

O trabalho em questão tem por objetivo realizar uma abordagem acerca do patrimônio histórico e cultural, de forma genérica, passando, posteriormente, à análise do Monumento ao Cristo Redentor, situado na cidade de Itaporanga, na Paraíba. Nessa perspectiva, este estudo, por meio da pesquisa exploratória, de natureza qualitativa, método dedutivo, coleta de dados bibliográfico e documental, procedeu-se de modo a realizar uma análise acerca da importância dos patrimônios históricos e culturais nacionais, associando-a à necessidade de preservação dos mesmos, através da atuação da administração pública em âmbito nacional, estadual e municipal. Nesse sentido, buscou-se ressaltar as origens e histórias que norteiam o referido patrimônio local, as quais justificam a necessidade de preservação, sendo esta uma atribuição da União, do Estado e do Município, com a colaboração da sociedade. Finalmente, diante da problemática exposta, buscou-se, embasado nos ditames que regem a Carta Constitucional, elucidar a necessidade da Administração Pública, pautada na defesa da cultura e história nacional, buscar atuar diante desse seu dever de proteção do patrimônio histórico-cultural nacional.
Initial development of Dipteryx alata Vog consortium with cover plants
Authors: Barbosa Kennedy de Araújo , Silva Fabiano Guimarães , Perin Adriano , Dornelles Paulo , Melo Aniela Pilar Campos de , Rubio Neto Aurélio , Dornelles Diego Pinheiro , Dário Bruno Matheus Mendes
Published: March 2021

Cover plants, due to their high biomass production capacity, and plants provide the soil with several benefits such as nutrient cycling, greater water retention and storage capacity, reduced temperature, increased aggregation and microbiota, physical protection against compaction. The objective of this work was to verify the growth of the fruit species of the cerrado, Dipteryx alata Vogel, as a consortium strategy with green fertilizers, Arachis pintoi Krapov. & W.C.Greg./Callopogonium mucunoides Desv., Crotalaria juncea L, Dolichos lablab L., [Urochloa decumbens (Stapf) R.D.Webster] with nitrogen and [Urochloa decumbens (Stapf) R.D.Webster] without nitrogen (control). The experiment covered the period from 2013 to 2017, in Rio Verde, Goiás, installed in a randomized block design, with five treatments (cover plants) and four replications. The evaluations included the macro and micronutrient contents in D. alata, biomass production by cover plants, soil moisture and biometric determinations of D. alata. The use of U. decumbens with nitrogen, D. lablab and C. juncea showed better performances in maintaining soil moisture, growth and early fruiting of D. alata, making it advantageous to use these types of consortium in its establishment under conditions of the Cerrado.
Estado do conhecimento da Teoria dos Registros de Representação Semiótica em anais da Jornada Nacional de Educação Matemática - JEM
Authors: Ribeiro Junior Osvaldo Antonio , Vieira Bárbara Medeiros , Costa Renata Gaspar da
Published: March 2021

Os eventos científicos são essenciais para a divulgação do conhecimento gerado pela ciência, é por meio deles que ocorre a comunicação entre cientistas e é possível observar o desenvolvimento de cada campo de pesquisa.  Portanto, este trabalho tem como objetivo apresentar uma visão geral das pesquisas que abordam a teoria dos registros de representação semiótica de Raymond Duval e o objeto matemático função. As pesquisas mapeadas são da Jornada Nacional de Educação Matemática - JEM, evento realizado na Universidade de Passo Fundo, no Rio Grande do Sul. Trata-se de um evento bienal, cuja primeira edição foi realizada em 2006 e atualmente está na sua oitava edição, realizada em 2020 e que ocorreu remotamente devido à pandemia de COVID – 19. Esta pesquisa possui abordagem qualitativa e o mapeamento é do tipo Estado de Conhecimento. Ressalta-se que o conteúdo de função foi considerado devido ser um dos conceitos mais importante na Matemática, sua ideia está presente no dia a dia, além de que possui grande aplicabilidade em outras áreas de conhecimento. Foi possível encontrar 19 trabalhos referentes à teoria de Duval, mas somente 7 faziam referência à função e se distribuem na II JEM, III JEM, V JEM e VII JEM. Percebeu-se que a segunda edição é a que mais apresenta resultados, com um total de 3. As pesquisas catalogadas pertencem a unidade federativa do Rio Grande do Sul, espera-se que nas próximas edições haja mais participações de outros estados e regiões.
Uso do sildenafil em paciente com hipertensão pulmonar: Um relato de caso
Authors: Beltrão Ilvanete Tavares , Silva Augusto César Beltrão da , Beltrão Renata Paula Lima , Mouta Alba Angélica Nunes , Portela Davi de Aguiar , Beltrão Camila Maila Fontinele , Carneiro Eduardo de Carvalho , Beltrão Bruna Caroline Ribeiro , Ferreira Neto José Krentel
Published: March 2021

O objetivo deste estudo é relatar um caso de paciente portador de doença pulmonar obstrutiva crônica (DPOC) e fibrose cística que evoluiu com hipertensão pulmonar, relatando os achados clínicos e o tratamento instituído. Os pacientes que possuem alguma doença pulmonar crônica têm maior propensão a desenvolver hipertensão pulmonar, condição que leva a elevação dos níveis na vascularização pulmonar, condição que leva a redução da sobrevida do portador. O diagnóstico dessa condição pode demorar até 2 anos, visto que a maior parte dos sintomas são inespecíficos, além da exigência de métodos invasivos para a confirmação do diagnóstico. A paciente do caso clínico apresentou sinais sugestivos de hipertensão pulmonar, além de radiografia de tórax condizente com os achados dessa patologia, por isso, foi iniciado tratamento com vasodilatador. O vasodilatador de escolha foi o sildenafil por ser um agente que causa benefícios aparentes para o paciente, sem grandes repercussões nos demais sistemas corporais.
O Índice de Desafios da Gestão Municipal – IDGM nas capitais da região Nordeste do Brasil no ano de 2018
Authors: Leite Michael Douglas Sousa , Candeia Roberlúcia Araújo , Olivera Marcos Macri , Belchior Verônica Cristian Soares de , Sarmento Thaise de Abreu Brasileiro , Lacerda Wendell de Almeida , Moura Wanessa Arnaud , Carneiro Tiago Douglas Cavalcante , Belchior Sandra Maijane Soares de , França Vinícius Campos de , Silva Oziel Oliveira da , Lima Moema da Nóbrega Euclides , Medeiros Júlia Marcia Lourenço de Almeida Martins , Silva Cleuton de Sousa , Nogueira Alysson Emanuel de Sousa , Sousa Gisely Gabriela Bezerra de , Pinto Nijair Araújo
Published: March 2021

O percurso da história brasileira retrata a vivencia de problemas de cunho socioeconômico, capazes de comprometer a gestão e desempenho dos municípios, Estados e da União. Neste aspecto, os indicadores existem com a finalidade de avaliar o grau do comprometimento dos gestores, contribuindo efetivamente para demonstrar os resultados das ações desses junto as comunidades. O presente artigo tem como objetivo analisar o Índice de Desafios da Gestão Municipal e a alocação de recursos em algumas funções estratégicas governamentais nas capitais da região do Nordeste no ano de 2018. Para tanto a presente pesquisa corresponde a um estudo quantitativo, documental e exploratório, com uso da estatística descritiva, onde os dados foram obtidos através da base de dados da Finanças do Brasil (FINBRA) divulgados pela Secretaria do Tesouro Nacional (STN) e do site MACROPLAN. Os resultados mostram que dentre as cidades pesquisadas Fortaleza, João Pessoa, Teresina e Recife apresentam os melhores indicadores. Os piores indicadores foram de Maceió e Aracajú. Como sugestões de pesquisas futuras espera-se que possa continuar a investigação ao longo dos anos, bem como verificar as diferenças regionais, variáveis demográficas, representação política e econômica.
Perfil do acadêmico de Enfermagem e o seu conhecimento sobre infecção do trato urinário: estudo descritivo
Authors: Oliveira Raphael Monteiro de , Miñan Luiza Francymara de Paula , Silva Rafael Pires , Pires Bruna Maiara Ferreira Barreto
Published: March 2021

Objetivo: Descrever o perfil do acadêmico de enfermagem de uma instituição privada e destacar qual o conhecimento do mesmo sobre Cateter Vesical de Demora. Metodologia: estudo descritivo, de abordagem quantitativa, realizado no período do segundo semestre de 2017 que visou à coleta de dados, de acadêmicos de enfermagem de todos os períodos do turno noturno através de um questionário estruturado e fechado. A pesquisa foi realizada em instituição de ensino superior de nível privada em Niterói, Rio de Janeiro, Brasil. Resultados: O perfil do acadêmico de enfermagem que ingressa em uma universidade privada, trata-se de um público de adultos jovens que já estão inseridos no mercado de trabalho e buscam a universidade, motivados pela ascensão da carreira, bem como melhoria de salários. O conhecimento dos acadêmicos torna-se homogêneo quando comparado no geral, mas quando separado dos profissionais de saúde, estes possuem um número de acertos maior, sugerindo que a atividade profissional pode ser um facilitador para assimilação do conteúdo. Conclusão: Conclui-se que o perfil sociodemográfico dos alunos de enfermagem não interfere no processo de aprendizagem e assimilação do conteúdo. Diante desses resultados, sugere outras pesquisas relacionadas aos dificultadores do processo de aprendizagem e o conhecimento do aluno sobre Infecção do Trato Urinário, bem como uma comparação do perfil acadêmico e o conhecimento do mesmo a cerca do tema em universidades públicas como comparativo e objetivo de melhoria na qualidade de educação e formação dos profissionais de enfermagem.
Análise socioeconômica e do conhecimento sobre saúde bucal das gestantes de alto risco
Authors: Mélo Cláudia Batista , Gomes Lucas de Medeiros , Souza Marcos do Nascimento , Alencar Michelle Lima , Santana Fernanda Mendes , Bonan Paulo Rogério Ferreti , Piagge Carmem Silvia Laureano Dalle
Published: March 2021

Este trabalho analisou o perfil socioeconômico e o conhecimento sobre saúde bucal das gestantes de alto risco atendidas no Hospital Universitário Lauro Wanderley (HULW) da Universidade Federal da Paraíba (UFPB). Trata-se de um estudo observacional, descritivo, transversal e de natureza quantitativa, o qual utilizou o programa Epi Info versão 7.2.4 para realizar a análise estatística dos dados. O estudo foi composto por 51 gestantes de alto risco, atendidas no HULW da UFPB, a partir da aplicação de um questionário estruturado, dividido em duas etapas; a primeira com 5 questões que abordavam o perfil socioeconômico das pacientes e a segunda com 7 questões referentes ao conhecimento e cuidados acerca da saúde bucal durante a gestação. Como parte dos resultados encontrados, em relação à faixa etária, 28 gestantes (54,90%) possuíam entre 24 a 33 anos; 45 (88,24%) possuíam até 2 salários-mínimos como renda familiar; 51 (100%) gestantes sabem o que é uma cárie, mas 33 (64,7%) acreditam que a cárie não é transmitida pela saliva. Quanto ao uso de anestésicos e radiografias durante a gravidez, 31 (60,78%) e 32 (62,74%), respectivamente, das pacientes acreditam não ser possível realizar tais procedimentos durante a gravidez. Conclui-se que o conhecimento das gestantes de alto risco acerca dos cuidados em saúde bucal durante a gestação é limitado, gerando divergências e lacunas nas respostas, predominando baixa escolaridade e nível de renda.
Acesso de pacientes com necessidades especiais em CEOs de Sergipe
Authors: Andrade Rosana Apolonio Reis , Meireles Amanda Caroline Nascimento , Almeida Alisson Augusto Gois de , Amaral Regiane Cristina do
Published: March 2021

A Política Nacional de Saúde Bucal foi instituída como ferramenta para possibilitar a integralidade das ações em saúde da população. Os Centros de Especialidades Odontológicas (CEO) se constituem como estabelecimentos essenciais, dentro da atenção secundária, para a continuidade da prestação de oferta dos serviços odontológicos especializados e efetivação do cuidado em saúde bucal. Assim, o presente estudo teve por objetivo avaliar a correlação entre as características socioeconômicas e demográficas dos pacientes com necessidades especiais (PNE) em Sergipe e acesso aos serviços dos CEOs Estaduais de Sergipe. Foram utilizados dados da FUNESA (Fundação Estadual de Saúde), e-Gestor e CECAD (Consulta, Seleção e Extração de Informações do CadÚnico). Foram avaliados 7 CEOs Estaduais (2018) e verificou-se correlação estatisticamente significativa para: cobertura de saúde bucal e pacientes especiais que recebem bolsa família (p=0,0007; r=-0.397); cobertura de saúde bucal e distância do município até a sede do CEO (p=0.0322; r=-0.2563); cobertura de saúde bucal e população do município que tem renda mensal per capta até R$178,00 (p=< 0.0001; r=-0.5418). A maior parte do atendimento dos pacientes ocorre dentro do próprio município sede. Há dificuldade de acesso do paciente com necessidades especiais em termos de referenciamento e assistência em percentual de cobertura de saúde bucal. O baixo percentual de cobertura de saúde bucal e de referenciamento dificultam o acesso dos PNE à assistência odontológica. As condições socioeconômicas e demográficas interferem no acesso dos PNE aos CEOs em Sergipe.
Atuação do profissional de Educação Física na equipe multidisciplinar do Consultório na Rua em Aracaju/SE: Relato de experiência
Authors: Silva Jadisson Gois da , Prado Rosa Luciana , Almeida Flávia Menezes , Avelino Maria de Lourdes Barros , Trindade Jayane Pinheiro , Silva Tharciano Luiz Teixeira Braga da , Mezzaroba Cristiano
Published: March 2021

O presente estudo tem como objetivo apresentar as experiências vividas por um Profissional de Educação Física (PEF) no exercício de suas funções numa equipe de Consultório na Rua (CR). Trata-se de um relato de experiência, acerca das vivências de um PEF residente Multiprofissional em Saúde Mental ao atuar no CR em Aracaju/SE, entre agosto de 2019 a fevereiro de 2020. Para a coleta dos dados utilizou-se a observação participante com os dados sendo elaborados em um diário de campo. Identificamos situações de preconceito e discriminação por parte da sociedade acerca da população em situação de rua; dificuldades de acesso à Rede de Atenção à Saúde (RAS); extrema vulnerabilidade social e notórias lacunas entre as políticas públicas de saúde e a sua aplicabilidade. Verificou-se a importância do trabalho da equipe do CR – um trabalho de cuidado e assistência desenvolvendo ações integradas com os serviços da RAS. Além disso, destaca-se a relevância da inserção do PEF no CR como agente que atua na perspectiva da integralidade do cuidado, desenvolvendo estratégias de promoção à saúde para além do seu núcleo de especificidade. Ademais, este atua frente às diferentes problemáticas e necessidades de saúde da referida população, inclusive na busca ativa aos usuários que fazem uso de drogas, contribuindo, também, para a realização do apoio matricial, acolhimento, educação em saúde, articulação intersetorial, e estratégias de redução de danos. Portanto, a Residência, torna-se uma potente estratégia para proporcionar processos de ensino e aprendizagens com vistas a uma formação continuada.
Anatomoclinical correlation and main radiological findings in a patient affected by Arnold Chiari's malformation: a review
Authors: Araújo Daniel Lopes , Nascimento Maxsuel Pereira do , Souza Maria Clara Teles de , Fernandes Andresa Salinny Carvalho , Diniz Maria das Graças de Azevedo , Oliveira Neto Francimar Alves de , Bandeira Letícia Araújo , Mendes Annarelly Morais , Machado Bruno Abilio da Silva , Cavalcante Lucas Leite , Sousa Bianca Barroso de
Published: March 2021

Chiari's malformation is within the spectrum of congenital abnormalities of the central nervous system (CNS). It is characterized by a complex deformity of the posterior fossa associated almost always with a malformation of the spine. Chiari malformation is still a subject of little evidence in literature, where new studies on this parameter may trigger influences for researchers in the field. The objectives of this study were to describe the main alterations found in the nervous system in individuals with Chiari malformation. It is a literature review study. The following descriptors were used for the search: Chiari malformation, Posterior Pit and Craniovertebral Junction (together and separately). In the selection criteria, full articles were chosen for the period: 2016 - 2019, in the languages: Portuguese and English. The searches were made in the databases: Scielo, Pubmed and Google academic. The articles were selected first by title, then by abstract, and finally by full reading. Based on the established criteria, 3 articles were selected that contemplate the theme. The literature shows that the most suggestive brain alterations of this pathology are cerebellar abnormalities such as caudal displacement of the bridge, IV ventricle and bulb; medullary torsion; IV ventricle in abnormal shape and hypoplasia of the cerebellum tent and mesencephalic ceiling. It is noticeable that Chiari's malformation can cause alterations that can vary from lighter to more severe. New studies are needed on this subject, as well as solutions to improve the quality of life of patients affected by this syndrome.
ZÁSADA OFICIALITY V ČESKÉM TRESTNÍM A CIVILNÍM PROCESU
Authors: Mulák Jiří , Vnenk Vladislav
Published: March 2021

Předmětem předloženého příspěvku je vysvětlení funkce právních zásad v českém civilním a trestním procesu, přičemž důraz je kladen na vysvětlení zásady oficiality v českém trestním i civilním procesu. S ohledem na systematiku a funkci zásad v procesních odvětvích práva nelze samozřejmě tuto zásadu popisovat izolovaně, ale naopak je nutné ji vysvětlit v kontextu a ve vzájemných souvislostech s ostatními zásadami.
Exosomal miR-3682-3p Suppresses Angiogenesis by Targeting ANGPT1 via the RAS-MEK1/2-ERK1/2 Pathway in Hepatocellular Carcinoma
Authors: Dong Shuang-Shuang , Dong Dan-Dan , Yang Zhang-Fu , Zhu Gui-Qi , Gao Dong-Mei , Chen Jie , Zhao Yan , Liu Bin-Bin
Published: March 2021

Background

Angiogenesis is a crucial process in tumorigenesis and development. The role of exosomes derived from hepatocellular carcinoma (HCC) cells in angiogenesis has not been clearly elucidated.

Methods and Results

Exosomes were isolated from HCC cell lines (HCCLM3, MHCC97L, and PLC/RFP/5) by ultracentrifugation and identified by nano transmission electron microscopy (TEM), NanoSight analysis and western blotting, respectively. In vitro and in vivo analyses showed that exosomes isolated from highly metastatic HCC cells enhanced the migration, invasion and tube formation of human umbilical vein endothelial cells (HUVECs) compared to exosomes derived from poorly metastatic HCC cells. In addition, microarray analysis of HCC-Exos was conducted to identify potential functional molecules, and miR-3682-3p expression was found to be significantly downregulated in exosomes isolated from highly metastatic HCC cells. By in vitro gain-of-function experiments, we found that HCC cells secreted exosomal miR-3682-3p, which negatively regulates angiopoietin-1 (ANGPT1), and this led to inhibition of RAS-MEK1/2-ERK1/2 signaling in endothelial cells and eventually impaired angiogenesis.

Conclusion

Our study elucidates that exosomal miR-3682-3p attenuates angiogenesis by targeting ANGPT1 through RAS-MEK1/2-ERK1/2 signaling and provides novel potential targets for liver cancer therapy.
Complex Crystal Structure Determination and in vitro Anti–non–small Cell Lung Cancer Activity of Hsp90N Inhibitor SNX-2112
Authors: Zhao Dong , Xu Yi-Ming , Cao Lu-Qi , Yu Feng , Zhou Huan , Qin Wei , Li Hui-Jin , He Chun-Xia , Xing Lu , Zhou Xin , Li Peng-Quan , Jin Xin , He Yuan , He Jian-Hua , Cao Hui-Ling
Published: March 2021

SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90N-SNX-2112 hindered further structural optimization and understanding on molecular interaction mechanism. Herein, a high-resolution complex crystal structure of Hsp90N-SNX-2112 was successfully determined by X-ray diffraction, resolution limit, 2.14 Å, PDB ID 6LTK, and their molecular interaction was analyzed in detail, which suggested that SNX-2112 was well accommodated in the ATP-binding pocket to disable molecular chaperone activity of Hsp90, therefore exhibiting favorable inhibiting activity on three non–small cell lung cancer (NSCLC) cell lines (IC50, 0.50 ± 0.01 μM for A549, 1.14 ± 1.11 μM for H1299, 2.36 ± 0.82 μM for H1975) by inhibited proliferation, induced cell cycle arrest, and aggravated cell apoptosis. SNX-2112 exhibited high affinity and beneficial thermodynamic changes during the binding process with its target Hsp90N confirmed by thermal shift assay (TSA, ΔTm, and −9.51 ± 1.00°C) and isothermal titration calorimetry (Kd, 14.10 ± 1.60 nM). Based on the complex crystal structure and molecular interaction analysis, 32 novel SNX-2112 derivatives were designed, and 25 new ones displayed increased binding force with the target Hsp90N verified by molecular docking evaluation. The results would provide new references and guides for anti-NSCLC new drug development based on the lead compound SNX-2112.
Identification of the Prognostic Significance of Somatic Mutation-Derived LncRNA Signatures of Genomic Instability in Lung Adenocarcinoma
Authors: Geng Wei , Lv Zhilei , Fan Jinshuo , Xu Juanjuan , Mao Kaimin , Yin Zhengrong , Qing Wanlu , Jin Yang
Published: March 2021

Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous tumor with substantial somatic mutations and genome instability, which are emerging hallmarks of cancer. Long non-coding RNAs (lncRNAs) are promising cancer biomarkers that are reportedly involved in genomic instability. However, the identification of genome instability-related lncRNAs (GInLncRNAs) and their clinical significance has not been investigated in LUAD.

Methods: We determined GInLncRNAs by combining somatic mutation and transcriptome data of 457 patients with LUAD and probed their potential function using co-expression network and Gene Ontology (GO) enrichment analyses. We then filtered GInLncRNAs by Cox regression and LASSO regression to construct a genome instability-related lncRNA signature (GInLncSig). We subsequently evaluated GInLncSig using correlation analyses with mutations, external validation, model comparisons, independent prognostic significance analyses, and clinical stratification analyses. Finally, we established a nomogram for prognosis prediction in patients with LUAD and validated it in the testing set and the entire TCGA dataset.

Results: We identified 161 GInLncRNAs, of which seven were screened to develop a prognostic GInLncSig model (LINC01133, LINC01116, LINC01671, FAM83A-AS1, PLAC4, MIR223HG, and AL590226.1). GInLncSig independently predicted the overall survival of patients with LUAD and displayed an improved performance compared to other similar signatures. Furthermore, GInLncSig was related to somatic mutation patterns, suggesting its ability to reflect genome instability in LUAD. Finally, a nomogram comprising the GInLncSig and tumor stage exhibited improved robustness and clinical practicability for predicting patient prognosis.

Conclusion: Our study identified a signature for prognostic prediction in LUAD comprising seven lncRNAs associated with genome instability, which may provide a useful indicator for clinical stratification management and treatment decisions for patients with LUAD.
COVID-19 and Computer Audition: An Overview on What Speech & Sound Analysis Could Contribute in the SARS-CoV-2 Corona Crisis
Authors: Schuller Björn W. , Schuller Dagmar M. , Qian Kun , Liu Juan , Zheng Huaiyuan , Li Xiao
Published: March 2021

At the time of writing this article, the world population is suffering from more than 2 million registered COVID-19 disease epidemic-induced deaths since the outbreak of the corona virus, which is now officially known as SARS-CoV-2. However, tremendous efforts have been made worldwide to counter-steer and control the epidemic by now labelled as pandemic. In this contribution, we provide an overview on the potential for computer audition (CA), i.e., the usage of speech and sound analysis by artificial intelligence to help in this scenario. We first survey which types of related or contextually significant phenomena can be automatically assessed from speech or sound. These include the automatic recognition and monitoring of COVID-19 directly or its symptoms such as breathing, dry, and wet coughing or sneezing sounds, speech under cold, eating behaviour, sleepiness, or pain to name but a few. Then, we consider potential use-cases for exploitation. These include risk assessment and diagnosis based on symptom histograms and their development over time, as well as monitoring of spread, social distancing and its effects, treatment and recovery, and patient well-being. We quickly guide further through challenges that need to be faced for real-life usage and limitations also in comparison with non-audio solutions. We come to the conclusion that CA appears ready for implementation of (pre-)diagnosis and monitoring tools, and more generally provides rich and significant, yet so far untapped potential in the fight against COVID-19 spread.
Daily Runoff Forecasting Using Ensemble Empirical Mode Decomposition and Long Short-Term Memory
Authors: Yuan Ruifang , Cai Siyu , Liao Weihong , Lei Xiaohui , Zhang Yunhui , Yin Zhaokai , Ding Gongbo , Wang Jia , Xu Yi
Published: March 2021

Hydrological series data are non-stationary and nonlinear. However, certain data-driven forecasting methods assume that streamflow series are stable, which contradicts reality and causes the simulated value to deviate from the observed one. Ensemble empirical mode decomposition (EEMD) was employed in this study to decompose runoff series into several stationary components and a trend. The long short-term memory (LSTM) model was used to build the prediction model for each sub-series. The model input set contained the historical flow series of the simulation station, its upstream hydrological station, and the historical meteorological element series. The final input of the LSTM model was selected by the MI method. To verify the effect of EEMD, this study used the Radial Basis Function (RBF) model to predict the sub-series, which was decomposed by EEMD. In addition, to study the simulation characteristics of the EEMD-LSTM model for different months of runoff, the GM(group by month)-EEMD-LSTM was set up for comparison. The key difference between the GM-EEMD-LSTM model and the EEMD-LSTM model is that the GM model must divide the runoff sequence on a monthly basis, followed by decomposition with EEMD and prediction with the LSTM model. The prediction results of the sub-series obtained by the LSTM and RBF exhibited better statistical performance than those of the original series, especially for the EEMD-LSTM. The overall GM-EEMD-LSTM model performance in low-water months was superior to that of the EEMD-LSTM model, but the simulation effect in the flood season was slightly lower than that of the EEMD-LSTM model. The simulation results of both models are significantly improved compared to those of the LSTM model.
Induced Seismicity Completeness Analysis for Improved Data Mining
Authors: Mignan Arnaud
Published: March 2021

The study of induced seismicity at sites of fluid injection is paramount to assess the seismic response of the earth’s crust and to mitigate the potential seismic risk. However statistical analysis is limited to events above the completeness magnitudemc, which estimation may significantly vary depending on the employed method. To avoid potential biases and optimize the data exploitable for analysis, a better understanding of completeness, detection capacity and censored data characteristics is needed. We apply various methods previously developed for natural seismicity on 16 underground stimulation experiments. We verify that different techniques yield differentmcvalues and we suggest using the 90% quantile of themcdistribution obtained from high-resolution mapping, withmcdefined from the mode of local magnitude frequency distributions (MFD). We show that this distribution can be described by an asymmetrical Laplace distribution and the bulk MFD by an asymmetric Laplace mixture model. We obtain an averaged Gutenberg-Richter parameterb=1.03±0.48and a detection parameterk=3.18±1.97 from mapping, with values subject to high uncertainties across stimulations. We transfer Bayesianmcmapping developed for natural seismicity to the context of induced seismicity, here adapted to local three-dimensional seismicity clouds. We obtain the new prior parameterizationmc,pred=1.64log10(d3)−1.83, withd3the distance to the 3rd nearest seismic station. The potential use of censored data and ofmcprediction is finally discussed in terms of data mining to improve the monitoring, modeling and managing of induced seismicity.
Cushing’s Syndrome With Nocardiosis: A Case Report and a Systematic Review of the Literature
Authors: Zhang Da , Jiang Yan , Lu Lin , Lu Zhaolin , Xia Weibo , Xing Xiaoping , Fan Hongwei
Published: March 2021

Objective

To analyze and summarize the clinical characteristics, treatments, and prognosis of Cushing’s syndrome (CS) with nocardiosis.

Methods

A patient in our hospital and additional 17 patients of CS with nocardiosis in the English literature were included in this study. Clinical characteristics, laboratory data, imaging studies, treatments, and prognosis were evaluated.

Results

A 41-year-old man with CS was diagnosed and treated in our hospital. He had co-infections of nocardiosis and aspergillosis. Together with 17 patients of CS with nocardiosis in the English literature, 2 patients (11.1%) were diagnosed as Cushing’s disease (CD) while 16 (88.9%) were diagnosed or suspected as ectopic ACTH syndrome (EAS). The average 24hrUFC was 7,587.1 ± 2,772.0 μg/d. The average serum total cortisol and ACTH (8 AM) was 80.2 ± 18.7 μg/dl and 441.8 ± 131.8 pg/ml, respectively. The most common pulmonary radiologic findings in CT scan were cavitary lesions (10/18) and nodules (8/18). Co-infections were found in 33.3% (6/18) patients. The CS patients with co-infections had higher levels of ACTH (671.5 ± 398.2 vs 245.5 ± 217.1 pg/ml, P = 0.047), and 38.9% (7/18) patients survived through the antibiotic therapy and the treatment of CS. Patients with lower level of ACTH (survival vs mortality: 213.1 ± 159.0 vs 554.7 ± 401.0 pg/ml, P = 0.04), no co-infection, underwent CS surgery, and received antibiotic therapy for more than 6 months, had more possibilities to survive.

Conclusions

Nocardia infection should be cautioned when a patient of CS presented with abnormal chest radiographs. The mortality risk factors for CS with nocardiosis are high level of ACTH and co-infections. We should endeavor to make early etiological diagnosis, apply long-term sensitive antibiotics and aggressive treatments of CS.
Sustainable Ammonia Production Processes
Authors: Ghavam Seyedehhoma , Vahdati Maria , Wilson I. A. Grant , Styring Peter
Published: March 2021

Due to the important role of ammonia as a fertilizer in the agricultural industry and its promising prospects as an energy carrier, many studies have recently attempted to find the most environmentally benign, energy efficient, and economically viable production process for ammonia synthesis. The most commonly utilized ammonia production method is the Haber-Bosch process. The downside to this technology is the high greenhouse gas emissions, surpassing 2.16 kgCO2-eq/kg NH3 and high amounts of energy usage of over 30 GJ/tonne NH3 mainly due to the strict operational conditions at high temperature and pressure. The most widely adopted technology for sustainable hydrogen production used for ammonia synthesis is water electrolysis coupled with renewable technologies such as wind and solar. In general, a water electrolyzer requires a continuous supply of pretreated water with high purity levels for its operation. Moreover, for production of 1 tonne of hydrogen, 9 tonnes of water is required. Based on this data, for the production of the same amount of ammonia through water electrolysis, 233.6 million tonnes/yr of water is required. In this paper, a critical review of different sustainable hydrogen production processes and emerging technologies for sustainable ammonia synthesis along with a comparative life cycle assessment of various ammonia production methods has been carried out. We find that through the review of each of the studied technologies, either large amounts of GHG emissions are produced or high volumes of pretreated water is required or a combination of both these factors occur.
Spatial Variation in Cadmium and Mercury and Factors Influencing Their Potential Ecological Risks in Farmland Soil in Poyang Lake Plain, China
Authors: Huang Xinyi , Yu Huimin , Zhao Xiaomin , Guo Xi , Ye Yingcong , Xu Zhe
Published: March 2021

Due to the irreversibility of heavy metal pollution, the presence of heavy metals in farmland soil is associated with severe ecological risks that endanger both the environment and human health. Cadmium (Cd) and mercury (Hg) are two toxic heavy metals found widely in polluted soil. Cd is not readily fixed in the soil and is therefore easily accumulated by plants, while Hg has a wide range of pollution sources. The aims of this study were to explore the spatial variation in Cd and Hg concentrations in farmland soil in Poyang Lake Plain, China, and to assess their potential ecological risks as influenced by natural and human factors. A total of 283 soil samples were obtained from Fengcheng city, central Jiangxi Province. Data were then analyzed using geostatistics, the potential ecological risk index, Pearson’s correlation analysis, and Geodetector. The results showed moderate variation in soil Cd and Hg concentrations, with a remarkable difference in their spatial distribution. Cd concentrations in the northwest and northeast of Fengcheng were below the regional background level in Jiangxi; in most remaining areas, Cd concentrations were between the regional background level and national risk screening value. Areas with Hg concentrations lower than the regional background level were largely concentrated in the south, east and north of Fengcheng, and gradually increased towards the central, where they exceeded the regional background level but were below the national risk screening value. Overall, the potential ecological risk level of Cd was predominantly low, while that of Hg was moderate. The comprehensive potential ecological risk was low in most areas for both Cd and Hg, with some scattered areas of moderate risk. Moreover, the comprehensive potential ecological risk index of both Cd and Hg was significantly correlated with soil pH, total phosphorous, elevation, distance from a river (p < 0.01), and distance from a road (p < 0.05). The most significant factor influencing the comprehensive potential ecological risk index of these two heavy metals was soil pH of 5.2–5.6, followed by total p ≤ 0.52 mg kg−1. In conclusion, moderate pollution of Cd and Hg occurred in farmland soil in Poyang Lake Plain where their comprehensive potential ecological risk level was generally low and mainly influenced by soil pH and total phosphorous.