bluuebunny/crossref_metadata_2025 huggingface dataset:
Social media analytics of the Internet of Things
Authors: Scheibmeir Jim A. , Malaiya Yashwant K.
Published: July 2021

The Internet of Things technology offers convenience and innovation in areas such as smart homes and smart cities. Internet of Things solutions require careful management of devices and the risk mitigation of potential vulnerabilities within cyber-physical systems. The Internet of Things concept, its implementations, and applications are frequently discussed on social media platforms. This research illuminates the public view of the Internet of Things through a content-based and network analysis of contemporary conversations occurring on the Twitter platform. Tweets can be analyzed with machine learning methods to converge the volume and variety of conversations into predictive and descriptive models. We have reviewed 684,503 tweets collected in a 2-week period. Using supervised and unsupervised machine learning methods, we have identified trends within the realm of IoT and their interconnecting relationships between the most mentioned industries. We have identified characteristics of language sentiment which can help to predict the popularity of IoT conversation topics. We found the healthcare industry as the leading use case industry for IoT implementations. This is not surprising as the current COVID-19 pandemic is driving significant social media discussions. There was an alarming dearth of conversations towards cybersecurity. Recent breaches and ransomware events denote that organizations should spend more time communicating about risks and mitigations. Only 12% of the tweets relating to the Internet of Things contained any mention of topics such as encryption, vulnerabilities, or risk, among other cybersecurity-related terms. We propose an IoT Cybersecurity Communication Scorecard to help organizations benchmark the density and sentiment of their corporate communications regarding security against their specific industry.
Principles of Scattering and Transport of Light
Authors: Carminati Rémi , Schotland John C.
Published: July 2021

Light scattering is one of the most well-studied phenomena in nature. It occupies a central place in optical physics, and plays a key role in multiple fields of science and engineering. This volume presents a comprehensive introduction to the subject. For the first time, the authors bring together in a self-contained and systematic manner, the physical concepts and mathematical tools that are used in the modern theory of light scattering and transport, presenting them in a clear, accessible style. The power of these tools is demonstrated by a framework that links various aspects of the subject: scattering theory to radiative transport, radiative transport to diffusion, and field correlations to the statistics of speckle patterns. For graduate students and researchers in optical physics and optical engineering, this book is an invaluable resource on the interaction of light with complex media and the theory of light scattering in disordered and complex systems.
The Epistemological Power of Taste
Authors: RICHARDSON LOUISE
Published: July 2021

It is generally accepted that sight—the capacity to see or to have visual experiences—has the power to give us knowledge about things in the environment and some of their properties in a distinctive way. Seeing the goose on the lake puts me in a position to know that it is there and that it has certain properties. And it does this by, when all goes well, presenting us with these features of the goose. One might even think that it is part of what it is to be a perceptual capacity that it has this kind of epistemological power, such that a capacity that lacked this power could not be perceptual. My focus in this essay is the sense of taste—the capacity to taste things or to have taste experiences. It has sometimes been suggested that taste lacks sight-like epistemological power. I argue that taste has epistemological power of the same kind as does sight, but that as a matter of contingent fact, that power often goes unexercised in our contemporary environment. We can know about things by tasting them in the same kind of way as we can know about things by seeing them, but we often do not. I then consider the significance of this conclusion. I suggest that in one way, it matters little, because our primary interest in taste (in marked contrast to our other senses) is not epistemic but aesthetic. But, I end by suggesting, it can matter ethically.
Comorbidities and Medical Complications in Hospitalized Subarachnoid Hemorrhage Patients
Authors: Schur Solon , Panagiotoglou Dimitra , Di Maio Salvatore , Buckeridge David
Published: July 2021

Background:

Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating condition with a case fatality of 36% at 30 days. Risk factors for mortality in SAH patients include patient demographics and the severity of the neurological injury. Pre-existing conditions and non-neurological medical complications occurring during the index hospitalization are also risk factors for mortality in SAH. The magnitude of the effect on mortality of pre-existing conditions and medical complications, however, is less well understood. In this study, we aim to determine the effect of pre-existing conditions and medical complications on SAH mortality.

Methods:

For a 25% random sample of the Greater Montreal Region, we used discharge abstracts, physician billings, and death certificate records, to identify adult patients with a new diagnosis of non-traumatic SAH who underwent cerebral angiography or surgical clipping of an aneurysm between 1997 and 2014.

Results:

The one-year mortality rate was 14.76% (94/637). Having ≥3 pre-existing conditions was associated with increased one-year mortality OR 3.74, 95% CI [1.25, 9.57]. Having 2, or ≥3 medical complications was associated with increased one-year mortality OR, 2.42 [95% CI 1.25–4.69] and OR, 2.69 [95% CI 1.43–5.07], respectively. Sepsis, respiratory failure, and cardiac arrhythmias were associated with increased one-year mortality. Having 1, 2, or ≥3 pre-existing conditions was associated with increased odds of having medical complications in hospital.

Conclusions:

Pre-existing conditions and in-hospital non-neurological medical complications are associated with increased one-year mortality in SAH. Pre-existing conditions are associated with increased medical complications.
Validation of the Bangla WHO-5 Well-being Index
Authors: Faruk Md. Omar , Alam Farzana , Chowdhury Kamal Uddin Ahmed , Soron Tanjir Rashid
Published: July 2021

Background

Subjective wellbeing in terms of objective outcome can be useful to determine the level of progress in clinical practice as well as research studies in Bangladesh. Besides, cultural understanding of well-being for Bangladeshi population is also equally important to report. A valid Bangla version of the five-item WHO Well-being Index can be a suitable measure to achieve the purposes. Therefore, the present study aimed at validating the WHO-5 Well-being Index for general population in Bangladesh.

Methods

After following the standard procedures for translation, back-translation, and committee translation, the initial Bangla version of the scale was developed and pretested. Based on the feedback during pretesting, a slight modification was made and the final version was developed. This final version was administered to 269 participants of different socioeconomic backgrounds to find out the reliability and validity of the scale from March 2019 to May 2019. The data analysis was conducted using SPSS 24.

Results

The scale demonstrated acceptable internal consistency (α = 0.754) and test-retest reliability (r = 0.713), divergent validity (r = −0.443, p < 0.01 with the Bangla version of Perceived Stress Scale-10) and convergent validity (r = 0.542, p < 0.01 with the Bangla version of Warwick-Edinburgh Mental Well-Being Scale). The data also yielded one-factor structure for the scale in exploratory factor analysis explaining 38.68% of total variance. The factor-structure was further supported in the confirmatory factor analysis (χ2 = 295.852, χ2/df = 2.017, RMSEA = 0.062, CFI = 0.986, TLI = 0.964, and SRMR = 0.0255).

Conclusion

The findings suggested the Bangla version of the WHO-5 Well-being Index is a psychometrically valid and reliable tool for general adult population in Bangladeshi when it comes to measuring subjective well-being both in clinical practice and research studies.
Using depiction for efficient communication in LIS (Italian Sign Language)
Authors: SLONIMSKA ANITA , ÖZYÜREK ASLI , CAPIRCI OLGA
Published: July 2021

abstract

Meanings communicated with depictions constitute an integral part of how speakers and signers actually use language (Clark, 2016). Recent studies have argued that, in sign languages, depicting strategy like constructed action (CA), in which a signer enacts the referent, is used for referential purposes in narratives. Here, we tested the referential function of CA in a more controlled experimental setting and outside narrative context. Given the iconic properties of CA we hypothesized that this strategy could be used for efficient information transmission. Thus, we asked if use of CA increased with the increase in the information required to be communicated. Twenty-three deaf signers of LIS described unconnected images, which varied in the amount of information represented, to another player in a director–matcher game. Results revealed that participants used CA to communicate core information about the images and also increased the use of CA as images became informatively denser. The findings show that iconic features of CA can be used for referential function in addition to its depictive function outside narrative context and to achieve communicative efficiency.
Distribution of the cestodeUrocystis proliferVillot, 1880 (Cyclophyllidea: Hymenolepididae) in the Palaearctic and new data on its postembryonic development
Authors: Kornienko S.A. , Ishigenova L.A.
Published: July 2021

Urocystis proliferVillot, 1880 is an intestinal parasite ofSorexspp. In the Palaearctic. There are significant differences in the descriptions of both adults and stages of ontogenesis ofU.proliferas described by various authors. The experimental infection of intermediate hosts with cestodes has been conducted. An overview of the geographical distribution, infestation of the definitive hosts and the development of the metacestode stages ofU.proliferare presented. The cestode is characterized by an extensive geographic area in the Palaearctic, wide host specificity and very high rates of infection of its definitive host.Urocystis proliferhas been recorded mostly in the taiga and forest zones of Palaearctic. Fourteen species ofSorexwere registered as the definitive host. Redescription ofU.proliferand an amended generic diagnosis are provided. A complete description of the ontogeny from oncosphere to fully developed metacestode is given. Features of development of the metacestode are an asexual larval reproduction, the absence of the anterior and posterior obturator valve in the cyst of the fully developed urocyst, as well as excretory bodies.
The vowel system of Santiago Mexquititlán Otomi (Hñäñho)
Authors: Mulík Stanislav , Amengual Mark , Avecilla-Ramírez Gloria , Carrasco-Ortíz Haydée
Published: July 2021

The present study provides an acoustic description of the vowel system of Santiago Mexquititlán Otomi (Hñäñho), an endangered and understudied Oto-Manguean language variety spoken in central Mexico. The goal of this production study was to determine whether the phonemic contrasts between Hñäñho vowels, as previously described impressionistically, are maintained in the acoustic realizations of a group of relatively balanced bilingual native speakers of Hñäñho or if Hñäñho phonemic categories are merging due to the extensive influence of Spanish. To this end, each Hñäñho speaker recorded a carefully designed list of 90 Hñäñho words and the resulting dataset of a total of 1507 tokens was subjected to analysis. Linear mixed-effects models were constructed to predict Bark scale correlates of vowel height (B1 – b0) and vowel frontness/backness (B2 – B1) and the Pillai scores were calculated in order to determine the degree of overlap for adjacent Hñäñho vowel pairs. The speakers’ Hñäñho vowels were also compared to their Spanish vowels. A list of five Spanish words was used and a total of 90 tokens of the Spanish vowels were recorded. The results confirm that the vowel system of Hñäñho, produced by older Hñäñho speakers, consists of 10 distinct phonemes. Hñäñho-specific phonetic details are discussed, including the fronted realization of the vowel /u/ as [u̟] and the lowering of the vowel /ɔ/ to [ɒ], which might lead to a future /a – ɔ/ merger. These findings underline the importance of early and sustained exposure to indigenous bilinguals’ native language for the maintenance of phonetic features of Hñäñho despite extensive contact with Spanish.
All Things Newin Singapore: On creativity, complexity, and usage associations in Englishes
Authors: Schneider Edgar W.
Published: July 2021

In January 2021, Singapore's national performing arts center ‘Esplanade – Theatres on the Bay’, known especially for the high-quality acoustics of its concert hall, ran a special program called ‘All Things New’, featuring concerts and other art performances. It was advertised on location (see Figure 1), by a leaflet (Figure 2), and in a one-minute video (https://www.esplanade.com/festivals-and-series/all-things-new/2021) also shared on YouTube (https://www.youtube.com/watch?v=7U-7Yw9sTPs), and introduced young artists and bands who performed on the institution's ‘Concourse’ and its open stage called ‘Outdoor Theatre’ (for an example, see Figure 3).
Covid Conversations 3: Elizabeth LeCompte and Kate Valk
Authors: LeCompte Elizabeth , Valk Kate , Shevtsova Maria
Published: July 2021

Elizabeth LeCompte co-founded The Wooster Group with like-minded pioneers in New York in 1975, leading and directing its collaborators as deaths, departures, and new arrivals have changed its composition and emphases over the decades, segueing into a world-wide uncertain present. Kate Valk joined in 1978, the last representative of The Wooster Group’s foundational period, apart from LeCompte herself, who is still a key member of the company. References in this conversation are primarily to works after 2016. LeCompte briefly remarks on the importance of Since I Can Remember – one of the Group’s ongoing works in progress in 2021 – as an archival project that draws on Valk’s memory of how Nayatt School was made during her formative years. Having become, since then, a quintessential Wooster Group performer, Valk extended her artistic skills to stage direction, undertaking, most recently, The B-Side (2017). Both the initiative and idea for the piece came from performer Eric Berryman, who had brought Valk the collection of blues, songs, spirituals, and preachings on the 1965 LP made from the research of scholar folklorist Bruce Chapman. Berryman had been inspired to approach Valk because of her exclusive use of unadulterated historical recordings in Early Shaker Spirituals (2014), her directorial debut. The main work in rehearsal during 2020 and which was still locked down by the Covid-19 pandemic at the time of this conversation is The Mother, a Wooster Group variant of Brecht’s dramatized version of Gorky’s novel, directed by LeCompte. LeCompte discusses the current situation, emphasizing the increased vulnerability of independent artists and small-scale theatre, while giving a glimpse of the disadvantages for such groupings built into the North American system of project funding. The Wooster Group is a salient example of small-scale theatre that, despite continually precarious conditions, which the pandemic has highlighted and exacerbated, has achieved its creative goals and has defined its place in the exploratory avant-garde flourishing vigorously in the 1960s and 1970s. This particular avant-garde, LeCompte believes, has seen various important developments over the years but might well now be counting its last days. The conversation here presented was recorded on 31 October 2020, transcribed by Kunsang Kelden, and edited by Maria Shevtsova, Editor of New Theatre Quarterly.
Dramatizing Chinese Intellectuals of the Republican Era in Face for Mr. Chiang Kai-shek: Encoding Nostalgia in a Comedy of Ideas
Authors: Li Yuan , Beaumont Tim
Published: July 2021

Face for Mr. Chiang Kai-shek, one of the most influential Chinese plays to have garnered attention in recent years, serves as a reminder of the importance of campus theatre in the formation and development of modern Chinese spoken drama from the early twentieth century onwards. As an old-fashioned high comedy that features witty dialogues and conveys philosophical and political ideas, it stands in opposition to such other forms of theatre in China today as the extravagant, propagandistic ‘main melody’ plays, as well as the experimental theatre of images. This article argues that the play’s focus on Chinese intellectuals of the Republican era and their ideas encodes nostalgia both in its dramatic content and theatrical form: the former encodes nostalgia for the Republican era through a nuanced representation of Chinese intellectuals of that period, while the latter encodes nostalgia for orthodox spoken drama (huaju) in the form of a comedy of ideas. Yuan Li (first author) is Professor of English in the Faculty of English Language and Culture, Guangdong University of Foreign Studies. She has published extensively on contemporary Chinese and Anglo-Irish drama, theatre, and cinema. Tim Beaumont (corresponding author) is Assistant Professor at the School of Foreign Languages at Shenzhen University. His research is primarily philosophical, and it is currently focused on the relationship between nineteenth-century liberal nationalism and contemporary multiculturalism.
Compact groups with a set of positive Haar measure satisfying a nilpotent law
Authors: ABDOLLAHI ALIREZA , SOLEIMANI MALEKAN MEISAM
Published: July 2021

The following question is proposed by Martino, Tointon, Valiunas and Ventura in [4, question 1·20]:

Let G be a compact group, and suppose that
\[\mathcal{N}_k(G) = \{(x_1,\dots,x_{k+1}) \in G^{k+1} \;|\; [x_1,\dots, x_{k+1}] = 1\}\]
has positive Haar measure in
$G^{k+1}$
. Does G have an open k-step nilpotent subgroup?

We give a positive answer for
$k = 2$
.
Estimating the case fatality ratio for COVID-19 using a time-shifted distribution analysis
Authors: Thomas B. S. , Marks N. A.
Published: July 2021

Estimating the case fatality ratio (CFR) for COVID-19 is an important aspect of public health. However, calculating CFR accurately is problematic early in a novel disease outbreak, due to uncertainties regarding the time course of disease and difficulties in diagnosis and reporting of cases. In this work, we present a simple method for calculating the CFR using only public case and death data over time by exploiting the correspondence between the time distributions of cases and deaths. The time-shifted distribution (TSD) analysis generates two parameters of interest: the delay time between reporting of cases and deaths and the CFR. These parameters converge reliably over time once the exponential growth phase has finished. Analysis is performed for early COVID-19 outbreaks in many countries, and we discuss corrections to CFR values using excess-death and seroprevalence data to estimate the infection fatality ratio (IFR). While CFR values range from 0.2% to 20% in different countries, estimates for IFR are mostly around 0.5–0.8% for countries that experienced moderate outbreaks and 1–3% for severe outbreaks. The simplicity and transparency of TSD analysis enhance its usefulness in characterizing a new disease as well as the state of the health and reporting systems.
Food recalls associated with foodborne disease outbreaks, United States, 2006–2016
Authors: Qiu Qihua , Dewey-Mattia Daniel , Subramhanya Sanjana , Cui Zhaohui , Griffin Patricia M. , Lance Susan , Lanier William , Wise Matthew E. , Crowe Samuel J.
Published: July 2021

About 800 foodborne disease outbreaks are reported in the United States annually. Few are associated with food recalls. We compared 226 outbreaks associated with food recalls with those not associated with recalls during 2006–2016. Recall-associated outbreaks had, on average, more illnesses per outbreak and higher proportions of hospitalisations and deaths than non-recall-associated outbreaks. The top confirmed aetiology for recall-associated outbreaks was Salmonella. Pasteurised and unpasteurised dairy products, beef and molluscs were the most frequently implicated foods. The most common pathogen−food pairs for outbreaks with recalls were Escherichia coli-beef and norovirus-molluscs; the top pairs for non-recall-associated outbreaks were scombrotoxin-fish and ciguatoxin-fish. For outbreaks with recalls, 48% of the recalls occurred after the outbreak, 27% during the outbreak, 3% before the outbreak, and 22% were inconclusive or had unknown recall timing. Fifty per cent of recall-associated outbreaks were multistate, compared with 2% of non-recall-associated outbreaks. The differences between recall-associated outbreaks and non-recall-associated outbreaks help define the types of outbreaks and food vehicles that are likely to have a recall. Improved outbreak vehicle identification and traceability of rarely recalled foods could lead to more recalls of these products, resulting in fewer illnesses and deaths.
Organising National Socialism: Nazi Organisation in Sweden and the Netherlands, 1931–1939
Authors: Kunkeler Celestine S.
Published: July 2021

This article compares the party apparatuses of the National Socialist Movement of the Netherlands and the National Socialist Workers’ Party of Sweden. These two parties, founded in the 1930s, both to some extent mimicked the organisational model of Hitler's party in Germany. While this has been frequently noted, the deployment of this model in practice has not been analysed in any detail. The article explores the specific characters of the Swedish and Dutch fascist party organisations diachronically vis-à-vis propaganda, member activism and internal cohesion, highlighting their changes, successes and failures. The comparison reveals that the party apparatus was highly dependent on the specifics of national infrastructure, demographic distribution and urbanisation and the physical landscape, with notable consequences for internal party cohesion and morale. In the final analysis the relative appeal and popularity of the parties is shown party be the result of how the Nazi organisational model was deployed in practice within each national context.
Blastomere movement correlates with ploidy and mosaicism in early-stage human embryos after in vitro fertilization
Authors: Zhang Xiaodong , Yang Jingwei , Han Wei , Li Chong , Huang Guoning
Published: July 2021

Embryos undergo chaotic division and decrease in quality on day 3 with a reduction in the rates of subsequent blastocyst formation. Disordered cleavage causes a deterioration in embryonic quality, here we assessed the relationship between an cleavage model in first mitosis and the chromosomal status of human embryos, and discuss the potential biological and clinical implications for the cleavage model as a single parameter that can be used to assess embryonic quality. Thirty-two infertile couples, with normal karyotypes and who underwent their first IVF cycle were recruited to donate one normal two-cell-stage embryo each for this study between 2019 and 2020. Twenty-eight two-cell embryos underwent preimplantation genetic testing of each blastomere, and four chaotic-division embryos were stained with Hoechst and cultured in a confocal laser-scanning microscopy incubator system. This system showed high specificity and PPV but low sensitivity and NPV using the CM in the prediction of euploidy, indicating that CM could be considered a screening method for embryo selection; additional observational studies using the CM to select transferable embryos are needed before it can be used in clinical practice.
Reflecting on meaning in an existential-reorientation group psychotherapy approach for cancer patients: A qualitative thematic analysis
Authors: Grassi Luigi , Sabato Silvana , Caruso Rosangela , Tiberto Elisa , Padova Silvia De , Ruffilli Federica , Folesani Federica , Nanni Maria Giulia , Martino Belvederi Murri , Zerbinati Luigi , Testoni Ines
Published: July 2021

Objective

The objectives of this study were to evaluate, in the Italian cultural context, breast cancer patients’ main meaning themes related to the experience of the disease, on the one side, and to be part of an existentially oriented group intervention, on the other.

Method

A short reorientation-existential (RET) group intervention, structured by using some tools and background from cognitive analytic therapy (CAT) and based on the meaning-centered psychotherapy (MCP) existential framework, was delivered to 29 breast cancer patients. The sessions were audio-recorded and transcribed verbatim, with the narratives from reflective exercises (meaning of the journey cancer, meaning of the journey of intervention) uploaded to computer software NVivo 11. Analysis of the transcripts emerged from reflective exercises on the personal meaning of cancer and the letters of meaning (goodbye letter) written by the patients to express the meaning of their experience in the group was conducted through the interpretative phenomenological analysis (IPA) framework.

Results

Four superordinate themes were identified in the exercise meaning of the experience of cancer, namely “sense of stigma and loneliness (the foreigner),” “guilt (unjust guilt and anticipatory guilt),” “reconsidering one's own life and nostalgia,” and “rebirth (a new life, life after life).” Three superordinate themes were found in the meaning of the group experience in the letters, namely “togetherness and gratitude,” “legacy,” and “acceptance.”

Significance of results

The study confirmed that a short group intervention, based on the existentially oriented framework and delivered in a public clinical healthcare setting, was enriched by focusing on the personal meaning of cancer. Some themes, such as loneliness, nostalgia, and rebirth, emerged during reflection giving, in written letters to participants, the sense of the group therapeutic experience.
Constraints on Element Mobility During Deformation Within the Seismogenic Zone, Shimanto Belt, Japan
Authors: Ramirez Gabrielle , Smye Andrew , Fisher Donald M. , Hashimoto Yoshitaka , Yamaguchi Asuka
Published: July 2021

Subduction interfaces exhibit a variety of slip behaviors, including megathrust and slow earthquakes. Field observations are consistent with crack‐seal deformation, in which tensile cracks are sealed by fluid‐transported solute. However, there are few constraints on the mass fluxes and length and time scales of such deformation and attendant increases in cohesion within the seismogenic zone. Here, we present a systematic geochemical investigation of mass transport associated with development of crack‐seal veins in the Shimanto Belt—an accretionary complex that preserves a record of plate boundary slip behavior at temperatures relevant to the seismogenic zone: 150–350°C. These mélanges show evidence for shear across decameter‐scale zones of deformation dominated by anastomosing scaly fabrics and pervasive veins. We use meso‐ and microstructural observations with geochemical observations of scaly fabrics and crack‐seal veins to evaluate the role of silica redistribution in healing fracture porosity along the plate interface and modulating slip behavior. Crack‐seal veins contain primarily quartz with albite and calcite, and vein textures provide evidence for partial sealing. Bulk rock analyses determined that the amount of phyllosilicates, specifically illite and chlorite, increases with temperature. A simple mass‐balance model based on the immobile chemical component TiO2 shows a systematic trend in mobility for all three mélanges and increased element mobility as a function of temperature. Scaly fabrics and veins show compositional evidence for locally sourced mineral redistribution. This study supports a model where development of scaly slip surfaces and fracture healing through temperature‐dependent mineral redistribution can impact slip behavior and fluid flow along the subduction plate interface.
How Forward‐Scattering Snow and Terrain Change the Alpine Radiation Balance With Application to Solar Panels
Authors: von Rütte F. , Kahl A. , Rohrer J. , Lehning M.
Published: July 2021

Rough terrain in mid‐ and high latitudes is often covered with highly reflective snow, giving rise to a very complex transfer of incident sunlight. In order to simplify the radiative transfer in weather and climate models, snow is generally treated as an isotropically reflecting material. We develop a new model of radiative transfer over mountainous terrain, which considers for the first time the forward scattering properties of snow. Combining ground‐measured meteorological data and high resolution digital elevation models, we show that the forward scattering peak of snow leads to a strong local redistribution of incident terrain reflected radiation. In particular, the effect of multiple terrain reflections is enhanced. While local effects are large, area‐wide albedo is only marginally decreased. In addition, we show that solar panels on snowy ground can clearly benefit from forward scattering, helping to maximize winter electricity production.
Significant Reductions in Crop Yields From Air Pollution and Heat Stress in the United States
Authors: Liu Xiang , Desai Ankur R.
Published: July 2021

The joint exposure of plants to surface ozone, atmospheric aerosols, and heat stress can lead to considerable decreases in crop yields. Surface ozone negatively impacts plant photosynthesis while aerosols can have positive or negative effects from its dual impact on light and temperature. Here, using a statistical model, we show that in the United States, as a result of improvements in air quality, the damages caused by ozone and aerosols have decreased since 1980. Historically, relative yield losses due to ozone were 8.7% and 4.8%, and due to aerosols were 11.3% and 23.2% for maize and soybean, respectively. Maize yields are more sensitive to ozone pollution while soybean yields are more sensitive to aerosol pollution. In future RCP 8.5 scenario, absent significant reductions in emissions or improvements in air quality, maize, and soybean would have on average, 58.5% and 36.9% additional yield reductions, respectively, mainly caused by warming. Future climate warming and fossil fuel combustion driven changes to air pollution may have differing impacts on crop yield and should be jointly considered in any assessment of U.S. food security.
Seismicity and Crustal Structure of the Southern Main Ethiopian Rift: New Evidence From Lake Abaya
Authors: Ogden C. S. , Keir D. , Bastow I. D. , Ayele A. , Marcou S. , Ugo F. , Woodward A. , Kibret B. A. , Gudbrandsson S.
Published: July 2021

The Main Ethiopian Rift (MER) has developed during the 18 Ma‐Recent separation of the Nubian and Somalian plates. Extension in its central and northern sectors is associated with seismic activity and active magma intrusion, primarily within the rift, where shallow (5 km) seismicity along magmatic centers is commonly caused by fluid flow through open fractures in hydrothermal systems. However, the extent to which similar magmatic rifting persists into the southern MER is unknown. Using data from a temporary network of five seismograph stations, we analyze patterns of seismicity and crustal structure in the Abaya region of the southern MER. Magnitudes range from 0.9 to 4.0; earthquake depths are 0–30 km.ratios of1.69, estimated from Wadati diagram analysis, corroborate bulk‐crustalratios determined via teleseismic P‐to‐S receiver functionH‐stacking and reveal a relative lack of mafic intrusion compared to the MER rift sectors to the north. There is a clear association of seismicity with the western border fault system of the MER everywhere in our study area, but earthquake depths are shallow near Duguna volcano, implying a shallowed geothermal gradient associated with rift valley silicic magmatism. This part of the MER is thus interpreted best as a young magmatic system that locally impacts the geothermal gradient but that has not yet significantly modified continental crustal composition via rift‐axial magmatic rifting.
Processing and Validation of FORMOSAT‐7/COSMIC‐2 GPS Total Electron Content Observations
Authors: Pedatella N. M. , Zakharenkova I. , Braun J. J. , Cherniak I. , Hunt D. , Schreiner W. S. , Straus P. R. , Valant‐Weiss B. L. , Vanhove T. , Weiss J. , Wu Q.
Published: July 2021

Slant absolute total electron content (TEC) is observed by the Formosa Satellite‐7/Constellation Observing System for Meteorology, Ionosphere, and Climate‐2 (FORMOSAT‐7/COSMIC‐2, F7/C2) Tri‐GNSS Radio Occultation System (TGRS) instrument. We present details of the data processing algorithms, validation, and error assessment for the F7/C2 global positioning system (GPS) absolute TEC observations. The data processing includes estimation and application of solar panel dependent pseudorange multipath maps, phase to pseudorange leveling, and estimation of separate L1C‐L2C and L1C‐L2P receiver differential code biases. We additionally perform a validation of the F7/C2 GPS absolute TEC observations through comparison with colocated, independent, TEC observations from the Swarm‐B satellite. Based on this comparison, we conclude that the accuracy of the F7/C2 GPS absolute TEC observations is less than 3.0 TEC units. Results are also presented that illustrate the suitability of the F7/C2 GPS absolute TEC observations for studying the climatology and variability of the topside ionosphere and plasmasphere (i.e., altitudes above the F7/C2 orbit of 550 km). These results demonstrate that F7/C2 provides high quality GPS absolute TEC observations that can be used for ionosphere‐thermosphere data assimilation as well as scientific studies of the topside ionosphere and plasmasphere.
Multirate Mass Transfer Approach for Double‐Porosity Poroelasticity in Fractured Media
Authors: Andrés Sandro , Dentz Marco , Cueto‐Felgueroso Luis
Published: July 2021

Natural and anthropogenic fractured aquifers and reservoirs are dual porosity matrix‐fracture systems, where the fracture network provides highly–conductive flow pathways and the low–permeability matrix stores most of the fluid. The coupling between flow and mechanical deformation in fractured media is often modeled using the classical theory of dual‐porosity poroelasticity (DPP), based on Barenblatt's hypothesis of pressure equilibrium inside the rock matrix blocks. Equilibrium can be expected if the matrix blocks are small and the matrix diffusion time is comparable to the flow time scales along the fractures. In practice, matrix blocks may be large enough so that diffusion time scales are long, and the equilibrium hypothesis breaks down. Here, we study nonequilibrium effects in coupled flow and deformation in fractured media. We compare analytical predictions and modeling results of coupled flow and deformation in heterogeneous fractured porous media. The theoretical analysis is a nonequilibrium, dual‐porosity model. We use this theory to (a) Reveal the limitations of classical DPP formulations. (b) Obtain the scalings for drainage and displacement to be expected for coupled flow and deformation in highly heterogeneous, fractured media. (c) Identify what behavior to expect in fractured aquifers and reservoirs regarding flow and deformation. We observe strong tailing in fluid fluxes and land subsidence that cannot be captured by the classical DPP approach or a single porosity effective medium approach. We show that theoretical predictions from the multirate DPP model and high‐fidelity models agree, even for highly heterogeneous matrix‐fracture systems, and reproduce the observed nonequilibrium effects.
Light People: Professor Lin Li
Authors: Wang Hui , Gu Heng
Published: July 2021

Editorial

How to deal with climate change, how to mitigate or even reverse it, maybe the hottest scientific topic of the 21st century. Do you know that a Chinese scientist and his team contributed to climate change control by reducing PM2.5 in diesel car exhaust by 35–40%? That scientist is Prof. Lin Li, a Fellow of the Royal Academy of Engineering and founder of the Laser Processing Research Centre at The University of Manchester, United Kingdom. Of course, this is only one example of Professor Li’s scientific achievements. As a pioneer of microsphere super-resolution lens, his team, in collaboration with Singapore colleagues, broke the optical diffraction limit in optical microscopic imaging, making real-time observation of biological viruses without interference possible. He also used lasers to synthesize new nanomaterials which kill drug-resistant bacteria while remaining harmless to healthy human cells, which led to the development and breakthrough of related research fields. We are much honored to have Professor Lin Li for an exclusive interview in which he recalls his years of scientific research experience and talks about the future development trend of laser material processing.
Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank
Authors: Zhu Xingxing , Ward Joey , Cullen Breda , Lyall Donald M. , Strawbridge Rona J. , Lyall Laura M. , Smith Daniel J.
Published: July 2021

Anhedonia is a core symptom of multiple psychiatric disorders and has been associated with alterations in brain structure. Genome-wide association studies suggest that anhedonia is heritable, with a polygenic architecture, but few studies have explored the association between genetic loading for anhedonia—indexed by polygenic risk scores for anhedonia (PRS-anhedonia)—and structural brain imaging phenotypes. Here, we investigated how anhedonia and PRS-anhedonia were associated with brain structure within the UK Biobank cohort. Brain measures (including total grey/white matter volumes, subcortical volumes, cortical thickness (CT) and white matter integrity) were analysed using linear mixed models in relation to anhedonia and PRS-anhedonia in 19,592 participants (9225 males; mean age = 62.6 years, SD = 7.44). We found that state anhedonia was significantly associated with reduced total grey matter volume (GMV); increased total white matter volume (WMV); smaller volumes in thalamus and nucleus accumbens; reduced CT within the paracentral cortex, the opercular part of inferior frontal gyrus, precentral cortex, insula and rostral anterior cingulate cortex; and poorer integrity of many white matter tracts. PRS-anhedonia was associated with reduced total GMV; increased total WMV; reduced white matter integrity; and reduced CT within the parahippocampal cortex, superior temporal gyrus and insula. Overall, both state anhedonia and PRS-anhedonia were associated with individual differences in multiple brain structures, including within reward-related circuits. These associations may represent vulnerability markers for psychopathology relevant to a range of psychiatric disorders.
Global Perspective of the Vitamin D Status of African-Caribbean Populations: A Systematic Review and Meta-analysis
Authors: Vearing Rebecca M. , Hart Kathryn H. , Darling Andrea L. , Probst Yasmine , Olayinka Aminat S. , Mendis Jeewaka , Ribeiro Helena , Thakur Siddhartha , Mendes Marcela , Charlton Karen , Lanham-New Susan A.
Published: July 2021

Background/Objectives

Vitamin D deficiency remains a global public health issue, particularly in minority ethnic groups. This review investigates the vitamin D status (as measured by 25(OH)D and dietary intake) of the African-Caribbean population globally.

Subjects/Methods

A systematic review was conducted by searching key databases (PUBMED, Web of Science, Scopus) from inception until October 2019. Search terms included ‘Vitamin D status’ and ‘African-Caribbean’. A random effects and fixed effects meta-analysis was performed by combining means and standard error of the mean.

Result

The search yielded 19 papers that included n = 5670 African-Caribbean participants from six countries. A meta-analysis found this population to have sufficient (>50 nmol/L) 25(OH)D levels at 67.8 nmol/L, 95% CI (57.9, 7.6) but poor dietary intake of vitamin D at only 3.0 µg/day, 95% CI (1.67,4.31). For those living at low latitudes ‘insufficient’ (as defined by study authors) 25(OH)D levels were found only in participants with type 2 diabetes and in those undergoing haemodialysis. Suboptimal dietary vitamin D intake (according to the UK recommended nutrient intake of 10 µg/day) was reported in all studies at high latitudes. Studies at lower latitudes, with lower recommended dietary intakes (Caribbean recommended dietary intake: 2.5 µg/day) found ‘sufficient’ intake in two out of three studies.

Conclusions

25(OH)D sufficiency was found in African-Caribbean populations at lower latitudes. However, at higher latitudes, 25(OH)D deficiency and low dietary vitamin D intake was prevalent.
Multilocus disease-causing genomic variations for Mendelian disorders: role of systematic phenotyping and implications on genetic counselling
Authors: Narayanan Dhanya Lakshmi , Udyawar Divya , Kaur Parneet , Sharma Suvasini , Suresh Narayanaswamy , Nampoothiri Sheela , do Rosario Michelle C. , Somashekar Puneeth H. , Rao Lakshmi Priya , Kausthubham Neethukrishna , Majethia Purvi , Pande Shruti , Ramesh Bhat Y. , Shrikiran Aroor , Bielas Stephanie , Girisha Katta Mohan , Shukla Anju
Published: July 2021

Multilocus disease-causing genomic variations (MGVs) and multiple genetic diagnoses (MGDs) are increasingly being recognised in individuals and families with Mendelian disorders. This can be mainly attributed to the widespread use of genomic tests for the evaluation of these disorders. We conducted a retrospective study of families evaluated over the last 6 years at our centre to identify families with MGVs and MGDs. MGVs were observed in fourteen families. We observed five different consequences: (i) individuals with MGVs presenting as blended phenotypes (ii) individuals with MGVs presenting with distinct phenotypes (iii) individuals with MGVs with age-dependent penetrance (iv) individuals with MGVs with one phenotype obscured by another more predominant phenotype (v) two distinct phenotypes in different individuals in families with MGVs. Consanguinity was present in eight (8/14, 57.1%) of them. Thirteen families had two Mendelian disorders and one had three Mendelian disorders. The risk of recurrence of one or more conditions in these families ranged from 25% to 75%. Our findings underline the importance of the role of a clinical geneticist in systematic phenotyping, challenges in genetic counselling and risk estimation in families with MGVs and MGDs, especially in highly inbred populations.
Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo
Authors: Janosz Ewa , Hetzel Miriam , Spielmann Hanna , Tumpara Srinu , Rossdam Charlotte , Schwabbauer Marc , Kloos Doreen , von Kaisenberg Constantin , Schambach Axel , Buettner Falk F. R. , Janciauskiene Sabina , Lachmann Nico , Moritz Thomas
Published: July 2021

Inherited deficiency of the antiprotease alpha-1 antitrypsin (AAT) is associated with liver failure and early-onset emphysema. In mice, in vivo lentiviral transduction of alveolar macrophages (AMs) has been described to yield protective pulmonary AAT levels and ameliorate emphysema development. We here investigated the pulmonary transplantation of macrophages (PMT) transgenic for AAT as a potential therapy for AAT deficiency-associated lung pathology. Employing third-generation SIN-lentiviral vectors expressing the human AAT cDNA from the CAG or Cbx-EF1α promoter, we obtained high-level AAT secretion in a murine AM cell line as well as murine bone marrow-derived macrophages differentiated in vitro (AAT MΦ). Secreted AAT demonstrated a physiologic glycosylation pattern as well as elastase-inhibitory and anti-apoptotic properties. AAT MΦ preserved normal morphology, surface phenotype, and functionality. Furthermore, in vitro generated murine AAT MΦ successfully engrafted in AM-deficient Csf2rb–/–mice and converted into a CD11c+/Siglec-F+AM phenotype as detected in bronchoalveolar lavage fluid and homogenized lung tissue 2 months after PMT. Moreover, human AAT was detected in the lung epithelial lining fluid of transplanted animals. Efficient AAT expression and secretion were also demonstrated for human AAT MΦ, confirming the applicability of our vectors in human cells.
A deep learning model for predicting next-generation sequencing depth from DNA sequence
Authors: Zhang Jinny X. , Yordanov Boyan , Gaunt Alexander , Wang Michael X. , Dai Peng , Chen Yuan-Jyue , Zhang Kerou , Fang John Z. , Dalchau Neil , Li Jiaming , Phillips Andrew , Zhang David Yu
Published: July 2021

Targeted high-throughput DNA sequencing is a primary approach for genomics and molecular diagnostics, and more recently as a readout for DNA information storage. Oligonucleotide probes used to enrich gene loci of interest have different hybridization kinetics, resulting in non-uniform coverage that increases sequencing costs and decreases sequencing sensitivities. Here, we present a deep learning model (DLM) for predicting Next-Generation Sequencing (NGS) depth from DNA probe sequences. Our DLM includes a bidirectional recurrent neural network that takes as input both DNA nucleotide identities as well as the calculated probability of the nucleotide being unpaired. We apply our DLM to three different NGS panels: a 39,145-plex panel for human single nucleotide polymorphisms (SNP), a 2000-plex panel for human long non-coding RNA (lncRNA), and a 7373-plex panel targeting non-human sequences for DNA information storage. In cross-validation, our DLM predicts sequencing depth to within a factor of 3 with 93% accuracy for the SNP panel, and 99% accuracy for the non-human panel. In independent testing, the DLM predicts the lncRNA panel with 89% accuracy when trained on the SNP panel. The same model is also effective at predicting the measured single-plex kinetic rate constants of DNA hybridization and strand displacement.
Dimensional reduction by geometrical frustration in a cubic antiferromagnet composed of tetrahedral clusters
Authors: Okuma Ryutaro , Kofu Maiko , Asai Shinichiro , Avdeev Maxim , Koda Akihiro , Okabe Hirotaka , Hiraishi Masatoshi , Takeshita Soshi , Kojima Kenji M. , Kadono Ryosuke , Masuda Takatsugu , Nakajima Kenji , Hiroi Zenji
Published: July 2021

Dimensionality is a critical factor in determining the properties of solids and is an apparent built-in character of the crystal structure. However, it can be an emergent and tunable property in geometrically frustrated spin systems. Here, we study the spin dynamics of the tetrahedral cluster antiferromagnet, pharmacosiderite, via muon spin resonance and neutron scattering. We find that the spin correlation exhibits a two-dimensional characteristic despite the isotropic connectivity of tetrahedral clusters made of spin 5/2 Fe3+ ions in the three-dimensional cubic crystal, which we ascribe to two-dimensionalisation by geometrical frustration based on spin wave calculations. Moreover, we suggest that even one-dimensionalisation occurs in the decoupled layers, generating low-energy and one-dimensional excitation modes, causing large spin fluctuation in the classical spin system. Pharmacosiderite facilitates studying the emergence of low-dimensionality and manipulating anisotropic responses arising from the dimensionality using an external magnetic field.