bluuebunny/crossref_metadata_2025 huggingface dataset:
``Because it is the Right Thing to Do'': Taking Stock of the Peer Reviewers’ Openness Initiative
Authors: Dahrendorf Maike , Hoffmann Tabea , Mittenbühler Maximilian , Wiechert Sera-Maren , Sarafoglou Alexandra , Matzke Dora , Wagenmakers Eric-Jan
Published: July 2019

In recent years, multiple initiatives have sought to improve the transparency and reproducibility of psychological research. One example is the Peer Reviewers’ Openness Initiative (PRO), which aims to promote the sharing of data and code. PRO signatories pledge to provide a full review only for manuscripts that publicly share data and code, or include a justification why sharing is not possible. The punitive element of this approach attracted criticism: PRO may be perceived as coercive and could lead to negative repercussions for its signatories. Therefore we conducted a survey to assess signatories’ experiences with PRO. Contrary to the criticism, the reported experiences were predominantly positive, and 92% (117/127) of the signatories who completed the survey indicated that they would sign the initiative again today. Only 19 out of 127 respondents (15%) experienced negative reactions related to their commitment to PRO. Almost 50 respondents suggested ways in which PRO could be improved. We conclude that, from the signatories’ perspective, the benefits of the PRO initiative outweigh its drawbacks.
The individual dynamics of affective expression on social media
Authors: Pellert Max , Garcia David , Schweighofer Simon
Published: July 2019

Understanding the temporal dynamics of affect is crucial for our understanding human emotions in general. In this study, we empirically test a computational model of affective dynamics by analyzing a large-scale dataset of Facebook status updates using text analysis techniques. Our analyses support the central assumptions of our model: After stimulation, affective states, quantified as valence and arousal, exponentially return to an individual-specific baseline. On average, this baseline is at a slightly positive valence value and at a moderate arousal point below the midpoint. Furthermore, affective expression, in this case posting a status update on Facebook, immediately pushes arousal and valence towards the baseline by a proportional value. These results are robust to the choice of the text analysis technique and illustrate the fast timescale of affective dynamics through social media text. These outcomes are of high relevance for affective computing, the detection and modeling of collective emotions, the refinement of psychological research methodology, and the detection of abnormal, and potentially pathological, individual affect dynamics.
Intergroup contact fosters more inclusive social identities
Authors: Reimer Nils Karl , Kamble Shanmukh Vasant , Schmid Katharina , Hewstone Miles
Published: July 2019

We examined how people construct their social identities from multiple group memberships—and whether intergroup contact can reduce prejudice by fostering more inclusive social identities. South Indian participants (N = 351) from diverse caste backgrounds viewed 24 identity cards, each representing a person with whom participants shared none, one, two, or all of three group memberships (caste, religion, nationality). Participants judged each person as “us” or “not us”, showing whom they included in their ingroup, and whom they excluded. Participants tended to exclude caste and religious minorities, replicating persistent social divides. Bridging these divides, cross-group friendship was associated with more inclusive identities which, in turn, were associated with more positive relations between an advantaged, an intermediate, and a disadvantaged caste group. Negative contact was associated with less inclusive identities. Contact and identity processes, however, did not affect entrenched opposition to (or undermine support for) affirmative action in advantaged and disadvantaged groups.
Monitoring and Management of Tomato Leaf Miner, (Tuta absoluta, Meyrick) in Kavrepalanchowk, Nepal
Authors: Adhikari Debraj , Subedi R , Gautam S , Pandit D P , Sharma D R
Published: July 2019

Available with full text.
Biology and Population Growth Parameters of Tomato Leaf Miner, (Tuta absoluta, Meyrick) (Gelechiidae: Lepidoptera), on Tomato in the Laboratory
Authors: Simkhada R. , Thapa R. B.
Published: July 2019

Available with full text.
Economic Analysis of Off-Season Tomato Production under Poly-House in Okhldhunga, Nepal
Authors: Kunwar B. , Maharjan B.
Published: July 2019

Available with full text.
Farmer's Willingness to Pay for Insurance in Chitwan District, Nepal
Authors: Pant P. K. , Dutta J. P. , Kattel R. R. , Dhungana S. M.
Published: July 2019

Available with full text.
Soil Nutrient Analysis of Amargadhi, Bagarkot and Alital VDCs of Dadeldhura, Nepal
Authors: Devkota S. , Sunar B. , Pandey A.
Published: July 2019

Available with full text.
Rice Seedling Age Influences Yield Attributes in Rainfed Condition
Authors: Shrestha G. , Chaudhary R. D. , Shrestha S.
Published: July 2019

Available with full text.
Evaluation of Lemon Grass (Cymbopogon citratus) Oil as a Growth Promoter on Broiler Chicken
Authors: Tiwari M. R. , Shah B. , Jha A. K.
Published: July 2019

Available with full text.
Employment Insurance: Interregional Redistribution versus Protection against Changing Labour Market Conditions
Authors: Pollak Andreas
Published: July 2019

In this article, I quantitatively investigate the business cycle properties of the Canadian unemployment insurance system, Employment Insurance (EI). EI is designed in such a way that the generosity of benefits depends on regional labour market conditions and thus varies over time with the state of the macro economy as well as geographically depending on local unemployment rates. Simulations of a life-cycle model with heterogeneous agents and search frictions show that the welfare impact of the temporal changes in EI generosity is extremely small. It is dominated by the distributional effects of regional differentiation—that is, regions with persistently high unemployment rates benefit from more generous EI benefits because they are subsidized by regions with low unemployment.
Two Types of (Slight) Flexibility in Bank of Canada Projections, 2003–2019
Authors: Smith Gregor W.
Published: July 2019

Central bankers and other economists sometimes describe the inflation targeting practiced in Canada as flexible. This flexibility refers to deferring the planned return of the Consumer Price Index (CPI) inflation rate to the 2 percent target. In this article, I outline two ways to measure flexibility: by seeing whether the forecast for future inflation varies with either (1) current values of inflation or output growth or (2) the forecast for future output growth. The latter correlation would suggest that the Bank of Canada aims to stabilize output growth in addition to stabilizing the inflation rate. I describe how to detect evidence of these two types of flexibility in the Bank of Canada’s own forecasts (also known as projections) from its quarterly Monetary Policy Report. However, there is little sign of economically significant flexibility between 2003 and 2019.
Tariffs and the Composition of Employment: Evidence from the Canada–US Free Trade Agreement
Authors: Chan Jeff
Published: July 2019

I analyze the effect of the Canada–US Free Trade Agreement (CUSFTA) on the composition of employment at the local labour market level in Canada. I construct local labour-market-level changes in tariffs for both exports and imports, exploiting regional differences in pre-CUSFTA industrial composition to obtain variation in the degree to which CUSFTA affected localities across Canada. I find that Census Divisions (CDs) that experienced larger Canadian tariff cuts against US imports experienced higher rates of self-employment. CDs with larger American tariff cuts against Canadian goods correspondingly experienced lower rates of self-employment. These self-employment effects are dampened in CDs with higher initial shares of educated people, immigrants, and female workers. I do not find any evidence that part-time employment is affected by CUSFTA tariff cuts. The findings in this article provide evidence that increasing trade openness between two developed countries can affect the prevalence of self-employment.
The Influence of Secondary Schoolteachers on Educational Sustainability in Mubi Nigeria.
Authors: Bashir Faizah Mohammed , Bornoma Aisha Haladu , Idris Hannatu Abdullahi
Published: July 2019

The implementation of effective public awareness programs for environmental sustainability depends on certain symbolic steps that require the contribution and participation of each stakeholder. This aspect is generally believed to be to a larger extent based on the understanding of the cultural, economic, political and environmental realities of the domain under consideration. This article assesses the level of environmental sustainability awareness of some schools in Mubi, a locality in the extreme North-Eastern part of Nigeria with its unique cultures and attitudes towards the subject. The teacher and his students were targeted in the survey since this is one important institution upon which the future of societies is based. The survey conducted reveals the level of practice of environmental sustainability among this strong media of information dissemination (primary and secondary schools). Areas of concern in the result of the assessment were highlighted. Recommendations in areas of further improvements were suggested.
Analisis Penerapan PSAK 109 Tentang Akuntansi Zakat, Infaq, dan Sedekah pada Badan Amil Zakat Nasional Kabupaten Majene.
Authors: Hadijah Sitti
Published: July 2019

Penelitian ini bertujuan untuk mengetahui : Penerapan akuntansi zakat,Infaq, dan Sedekah berdasarkan PSAK 109 kepada Badan amil Zakat NasionalKabupaten Majene tahun 2014-2016. Data yang digunakan adalah data primer dandata sekunder. Teknik pengambilan data dilakukan dengan wawancara dan studidokumentasi. Metode analisis yang digunakan adalah analisis deskriptif kualitatif.Hasil penelitian ini menunjukkan pengelolaan Badan Amil zakat NasionalKab. Majene tahun 2014-2016 Untuk pengelolaan keuangan yang didalamnyaterdapat Pengakuan, pengukuran, penyajian dan Pengungkapn belum sepenuhnyamengarah pada implementasi yang sesuai dengan aturan yaitu PSAK 109 yangmengatur tentang Akuntansi zakat dan Infaq/ sedekah.
Evaluasi Sistem Pengendalian Internal Atas Siklus Pengeluaran Kas Pada Badan Usaha Milik Daerah (Studi Pada PDAM Tirta Manakarra Kabupaten Mamuju)
Authors: Hayadin Ridwan
Published: July 2019

PDAM Tirta Manakarra merupakan badan usaha milik daerah yang berlokasikan jalan Kurunggan Bassi Nomor 7 Kabupaten Mamuju, Sulawesi Barat. PDAM Tirta Manakarra berfokus pada bidang usaha yang menyediakan jasa layanan air minum dan air bersih kepada masyarakat umum. Penelitian ini, dilatar belakangi dengan hasil temuan audit di Tahun 2015 pada PDAM Tirta Manakarra tentang pengeluaran kas yang tidak sesuai peraturan. Penelitian ini bertujuan untuk mengevaluasi sistem pengendalian internal atas siklus pengeluaran kas berdasarkan lima komponen COSO, yakni: lingkungan pengendalian, penilaian risiko, aktivitas pengendalian, informasi dan komunikasi, serta monitoring. Penelitian ini dilakukan dengan cara membandingkan penerapan pengendalian internal atas siklus pengeluaran kas dengan pengendalian internal berdasarkan COSO, Penilaian pengendalian internal atas siklus pengeluaran kas PDAM Tirta Manakarra dibutuhkan data-data berupa: observasi, wawancara, dokumentasi, inspeksi dan konfirmasi. Hasil penelitian ini menunjukkan bahwa sistem pengendalian internal atas siklus pengeluaran kas pada lima komponen tidak efektif, sehingga perusahaan belum menunjang tujuan sistem pengendalian internal dalam aktivitas pengeluaran kas.
Practicas alimentarias y factores asociados al estado nutricional de lactantes ingresados al Programa Alimentario Nutricional Integral en un servicio de salud
Authors: Irala Pamela , González Vanessa , Sánchez Bernal Susana , Acosta José
Published: July 2019

Introducción: Niño/as con desnutrición son usuarios del Programa Alimentario Nutricional Integral (PANI), poco se sabe de sus prácticas alimentarias o condiciones sociodemográficas. Objetivo: Evaluar la asociación de las prácticas alimentarias y variables sociodemográficas con el estado nutricional de lactantes de 6 a 23 meses usuarios al Programa Alimentario Nutricional Integral (PANI). Materiales y Métodos: Estudio de casos y controles, con niños de 6-23 meses del Hospital Materno Infantil de San Lorenzo asignados a 2 grupos: a)Gupo Estudio-GE: 25 niños del PANI (desnutridos(DNT) o riesgo de desnutrir(RD) b)Grupo Control-GC: 25 niños eutróficos E), pareados por edad y sexo. Se averiguó sobre alimentación y variables sociodemográficas. Fueron utilizados c2, Mann Whitney, T Student y regresión logística, p<0,05 fue significativo. Resultados: Previa aprobación de Comité de Ética, fueron evaluados 50 niños, la mediana de edad fue 13,9 meses, el 72% (18/25 por grupo) eran varones en ambos grupos, 46/50 (92%) pertenecían a zona urbana. En GE tenían RD 20/25(80%) niños, DNT 5/20(20%); en GC todos eutroficos. No hubo diferencias significativas entre grupos, acceso a agua y saneamiento, duración de lactancia materna (LM) exclusiva o inicio de alimentación complementaria. El GE presentó menor promedio de peso de nacimiento que el GC (2724,6 vs 3430,6 gramos; Mann-Whitney, p=0,001), menor duración de LM total (7,5 vs 10,7 meses, T Student p=0,04), menor escolaridad materna (8,68 vs 10,4años; T Student p=0,03). en el ingreso económico.) Conclusión: Menor peso de nacimiento, escolaridad materna y de tiempo de lactancia materna se asocian a peor estado nutricional del niño, pero ninguna es predictora.

Correspondencia: Susana Sánchez Bernal Correo: susana.sanchez.ber@gmail.com

Conflicto de interés: Los autores declaran no poseer conflicto de interés

Recibido: 16/07/2019    Aceptado:21/07/2019
SUB-CHRONIC MPTP-INDUCED PARKINSONISM: SELECTIVE SENSITIVITY OF THE BALB/c MICE AND THE PROPHYLACTIC ROLES OF NIGELLA SATIVA OIL
Authors: Folarin Royhaan , Olonade Akinola , Ogunkunle Praise , Shallie Philemon , Adenowo Thomas , Adeyanju Muinat , Folarin Paul , Amangele Tarilayefa
Published: July 2019

Parkinsonism is a degenerative neurological syndrome characterised by dopamine deficiency in the basal ganglia. Despite ages of research, there is still lack of holistic and side-effect-free therapy for the disease. Nigella sativa is a multi-potent plant known for its historical and scientifically proven therapeutic potentials in the brain and other body organs. Despite the validity debates on the use of BALB/c mice strains in the modelling of Parkinsonism using MPTP, this study re-appraised the sensitivity versus resistance of the BALB/c mice strain to MPTP and further investigated the possible neuro-thrapeutic role of Nigella sativa oil (NSO) in the Parkinsonic endophenotypes elicited by MPTP in the BALB/c strain. Body weights, relative brain weights, striatal dopamine, striatal neuron density and recognition memory were studied in thirty-two (32) male albino mice, weighing between 18g -25g. They were divided equally into Control (administered with normal feed for 5 days), MPTP (administered with 18mg/kg MPTP i.p for 5 days), NS (administered with 1ml/kgbw NSO p.o. for 5 days), and NS+MPTP (administered with 1ml/kgbw NSO p.o. followed by 18mg/kg MPTP i.p for 5 days). Recognition memory was assayed through Novel Object Recognition test (NORT), and the animals were weighed and euthanised 24 hours after last administration. The brains were excised and the striatum assayed neurochemically for dopamine and illustrated histologically for neuronal density using the H&E stain. Parkinsonic traits such as mild tremor, significant down-regulation of dopamine and striatal neurons (p<0.05) were recorded in the BALB/c mice administered with MPTP only, confirming MPTP-sensitivity for these features. However, significant increase (p<0.05) in appetite, body weight, brain-body weight ratio, and recognition memory was also recorded in the MPTP-administered mice, though Nigella sativa was significantly prophylactic against the negative Parkinsonic features, and ‘moderative’ of the up-regulations induced by MPTP. While this suggests selective MPTP sensitivity and resistance in BALB/c strains, this study recommends the investigation of possible beneficial potentials of MPTP as observed. The research was conducted in conformance with the Animal Research Ethics Committee (AREC) guidelines of the Olabisi Onabanjo University.
Evaluasi Kesesuaian Lahan untuk Tanaman Jagung di Kabupaten Dompu Berbasis SIG
Authors: Puji Lestari Sri Apriani , Widayanti Baiq Harly
Published: July 2019

Evaluasi tingkat kesesuain lahan untuk tanaman jagung diperlukan untuk meningkatkan produksi pertanian dan mengoptimalkan penggunaan lahan secara bekesinambungan. Tujuan penelitian ini adalah menyajikan data dan informasi terkait wilayah mana yang cocok untuk pengembanagan tanaman jagung berbasis sistem informasi geografis sehingga bisa dijadikan sebagai bahan pertimbangan dalam perencanaan dan pengembangan wilayah di Kabupaten Dompu. Variabel pengukuran yang digunakan terdiri dari:temperature, ketersediaan air,(curah hujan), ketersediaan oksigen (kondisi drainase tanah), media perakaran(tekstur tanah), bahaya erosi (kelerengan), bahaya banjir (genangan), dan penggunaan lahan. Dari tujuh variabel tersebut menghasilkan tujuh peta yang kemudian di-overlay. Berdasarkan hasil analisa kesesuain lahan tanaman jagung di kabupaten dompu sebesar 30,40% lahan sangat sesuai, 34,51% cukup sesuai, 2,15% sesuai marginal dan 31,94% tidak sesuai untuk ditanami jagung. Pengembangan budidaya jagung di wilayah Dompu yang paling baik adalah pada wilayah dengan kelas sangat sesuai
Analisis Pengaruh Produks Komoditas Jagung Terhadap Pengembangan Wilayah di Kecamatan Manggelewa Kabupaten Dompu
Authors: Hidayah Nur , Widayanti Baiq Harly
Published: July 2019

Tujuan dari penelitian ini antara lain adalah untuk mengidentifiksi pengaruh komoditas jagung di Kecamata Manggelewa Kabupaten Dompu terhadap pengembangan wilayah Kecamatan Manggelewa serta memberikan arahan untuk pengembangan wilayah. Metode yang digunakan dalam penelitian ini yaitu Deskriptif – Kuantitatif, dengan menggunakan analisis regresi dan analisis SWOT (Efas-Ifas) sebagai acuan dalam menetapkan strategi pengembangan wilayah berbasis komoditas jagung di Kecamatan Manggelewa. Berdasarkan hasil analisis menunjukan bahwa benefit yang diperoleh petani jagung berdampak positif terhadap pengembangan wilayah di Kecamatan Manggelewa serta Kabupaten Dompu. Upaya pengembangan yang dapat dilakukan yaitu memperbaiki  jaringan jalan, meningkatkan hasil produksi jagung dalam jangka 5 tahun berikutnya meningkat di atas 5,113%, meingkatkan sarana transportasi, meningkatkan sarana penunjang kegiatan perekonomian rakyat, meningkatkan hubungan kerja sama antara masyarakat, pemerintah dan swasta, meningkatkan kesiapan kemampuan tenaga kerja, meningkatkan pengelolaan lahan pertanian dengan baik
Revitalisasi Bangunan Tua Kota Tua Ampenan Sebagai Kawasan Heritage di Kelurahan Ampenan Tengah Kota Mataram
Authors: Kusyadin Kusyadin , Yuniarman Ardi
Published: July 2019

Tujuan dari penelitian ini adalah merumuskan konsep revitalisasi bangunan tua ampenan sebagai kawasan heritage di Kelurahan Ampenan Tengah Kecamatan Ampenan. Pendekatan yang digunakan pada penelitian ini adalah pendekatan emperik rasional,artinya data dikumpulkan sesuai dengan tujuan dan secara rasional dan disusun kesimpulan-kesimpulan yang dapat ditarik dari data-data yang terkumpul. Berdasarkan hasil analisis data yang telah dilakukan, maka dirumuskanlah konsep penataan tata bangunan dan lingkungan dengan memperhatikan Struktur Peruntukan Lahan yang tetap mempertahankan keregaman tata guna yang seimbang dan terintegrasi, mengendalikan jenis peruntukan lahan, mengatur kepadatan pengembangan kawasan dengan mempertimbangkan daya dukung dan karakter kawasan serta menata ruang yang manusiawi dan beriontasi pada penjalan kaki dan aktivitas yang diwadahi. Selain itu tetap mengatur Koefisien Dasar Bangunan(KDB),  Koefisien Lantai Bangunan (KLB), Koefisien Daerah Hijau (KDH), Sistem Sirkulasi, dan Tata kualitas lingkungan. Penataan yang dilakukan diharapkan mendapatkan nilai tambah yang optimal terhadap priduktivitas ekonomi, sosial dan budaya kawasan perkotaan
Kajian Preferensi Stakeholder Terhadap Kebijakan Jalan Berbayar dan Parkir Progresif Studi Kasus di Wilayah Urban dan Sub Urban, Kota Balikpapan
Authors: Syafitri Elin Diyah
Published: July 2019

Tujuan penelitian mengidentifikasi instrumen kebijakan yang paling dapat diterima oleh stakeholder dan merekomendasikan pendekatan manajemen stakeholder untuk meminimalkan potensi konflik. Penelitian dilakukan di Kota Balikpapan. Dua pilihan kebijakan, road pricing dan parkir progresif dievaluasi melalui pengukuran preferensi dan analisis pemangku kepentingan. Stakeholder dibagi menjadi 3 kelompok yaitu beneficiaries, decision maker, dan influence group. Respon stakeholder dihitung menggunakan borda count method dan analisis preference.  Studi ini menemukan kebijakan parkir progresif lebih diterima oleh stakeholder daripada kebijakan jalan berbayar, baik di wilayah urban dan sub urban. Disimpulkan bahwa kebijakan parkir progresif lebih diterima ketika harus diterapkan di Kota yang sedang berkembang daripada kebijakan jalan berbayar.
Identifikasi Area Pengembangan RTH sebagai Fungsi Ekologis Penyerap Air Hujan di Kecamatan Rungkut Kota Surabaya
Authors: Angelia Tisa , Santoso Eko Budi
Published: July 2019

Changes in land use have resulted in decreasing green open space as part of green infrastructure. Identification of areas that have potential to develop green open space as rain water absorbers aims to reduce flooding/puddle in Rungkut Distric. The type of research used is quantitative, with overlay analysis techniques. Based on the results of the overlay analysis, there are some areas had the highest weight for developing rainwater absorbent green open space, namely Tulus Harapan Housing (11,7%) and Rungkut Harapan Housing (11,7%). The results of this research were the Kalirungkut Subdistrict as the smallest administrative area that would facilitate goverment policy making related to the development of rainwater absorbing green open space.
Essential amino acid tryptophan inhibits induction of inducible nitric oxide synthase gene expression in interleukin-1β stimulated hepatocytes
Authors: Tsuda Takumi , Miki Hirokazu , Nakatake Richi , Sakaguchi Tatsuma , Hatta Masahiko , Okumura Tadayoshi , Nishizawa Mikio , Kaibori Masaki
Published: July 2019

Background/objective: Tryptophan exerts protective effects against a variety of organ inflammation and injury, including liver. However, there are few scientific reports about the mechanisms involved in the action. Pro-inflammatory cytokine interleukin (IL)-1β stimulates the induction of inducible nitric oxide synthase (iNOS) expression and NO production in cultured hepatocytes (“in vitro liver injury model”), and the prevention of iNOS expression and NO production is considered to be an indicator of liver protection. This study aimed to examine whether tryptophan influences the induction of iNOS gene expression and the mechanisms.Methods: Tryptophan was added into primary cultures of rat hepatocytes stimulated by IL-1β. The iNOS induction, NO production and its signaling pathway were analyzed.Results: IL-1β induced iNOS gene expression, which was followed by iNOS expression and NO production. Tryptophan inhibited the expression of iNOS mRNA and protein, and decreased the production of NO. Transfection experiments with iNOS promoter-luciferase constructs revealed that tryptophan reduced the activities of iNOS mRNA synthesis and its stability. Tryptophan blocked two essential signaling pathways, the activation of nuclear factor (NF)-κB and upregulation of type I IL-1receptor (IL-1RI).Conclusions: Results indicate that tryptophan can prevent the NO production by the inhibition of iNOS gene expression, in part through NF-κB activation and IL-1RI upregulation, in inflamed hepatocytes. Tryptophan may be a potential therapeutic treatment in injured organs, including liver.Key words: tryptophan, inducible nitric oxide synthase, nitric oxide, cultured hepatocytes, nuclear factor-κB, type I interleukin-1 receptor
Causative Mutations and Genetic Risk Factors in Sporadic Early Onset Alzheimer’s Disease Before 51 Years
Authors: Lacour Morgane , Quenez Olivier , Rovelet-Lecrux Anne , Salomon Bruno , Rousseau Stephane , Richard Anne-Claire , Quillard-Muraine Muriel , Pasquier Florence , Rollin-Sillaire Adeline , Martinaud Olivier , Zarea Aline , de la Sayette Vincent , Boutoleau-Bretonniere Claire , Etcharry-Bouyx Frédérique , Chauviré Valérie , Sarazin Marie , le Ber Isabelle , Epelbaum Stéphane , Jonveaux Thérèse , Rouaud Olivier , Ceccaldi Mathieu , Godefroy Olivier , Formaglio Maite , Croisile Bernard , Auriacombe Sophie , Magnin Eloi , Sauvée Mathilde , Marelli Cecilia , Gabelle Audrey , Pariente Jeremie , Paquet Claire , Boland Anne , Deleuze Jean-François , Campion Dominique , Hannequin Didier , Nicolas Gael , Wallon David ,   The collaborators of the CNR-MAJ
Published: July 2019

Background:

Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, or APP, APOE4 alleles, and rare variants within TREM2, SORL1, and ABCA7 contribute to early-onset Alzheimer’s disease (EOAD). However, sporadic EOAD patients have been insufficiently studied to define the probability of being a carrier of one of these variants.

Objective:

To describe the proportion of each genetic variation among patients with very young-onset sporadic AD.

Methods:

We first screened PSEN1, PSEN2, and APP in 154 EOAD patients with an onset before 51 years and a negative family history. Among 99 patients with no mutation (NMC), whole exome sequencing (WES) was performed. We analyzed the APOE genotype and rare protein-truncating or missense predicted damaging variants of TREM2, SORL1, and ABCA7. Neurological examination and cerebrospinal fluid (CSF) biomarkers were systematically retrieved.

Results:

Nineteen (12.3%) mutation carriers (MC) harbored an APP or PSEN1 pathogenic or likely pathogenic variant. Among the NMC, 54/99 carried at least one genetic risk factor, including 9 APOE4/E4 homozygous, 37 APOE4 heterozygous, and 14 with a rare variant in another risk factor gene: 3 SORL1, 4 TREM2, and 9 ABCA7. MC presented an earlier disease onset ( p < 0.0001) and associated neurologic symptoms more frequently ( p < 0.002). All but one patient had at least 2 CSF biomarkers in abnormal ranges.

Conclusion:

The genetic component of very early sporadic EOAD gathers a substantial proportion of pathogenic variants in autosomal dominant genes and an even higher proportion of patients carrying genetic risk factors, suggesting an oligogenic determinism, even at this range of ages.
Positron emission tomography image reconstruction using feature extraction
Authors: Gao Juan , Zhang Qiyang , Liu Qiegen , Zhang Xuezhu , Zhang Mengxi , Yang Yongfeng , Liang Dong , Liu Xin , Zheng Hairong , Hu Zhanli
Published: July 2019

PURPOSE:

To reduce the cost of positron emission tomography (PET) scanning systems, image reconstruction algorithms for low-sampled data have been extensively studied. However, the current method based on total variation (TV) minimization regularization nested in the maximum likelihood-expectation maximization (MLEM) algorithm cannot distinguish true structures from noise resulting losing some fine features in the images. Thus, this work aims to recover fine features lost in the MLEM-TV algorithm from low-sampled data.

METHOD:

A feature refinement (FR) approach previously developed for statistical interior computed tomography (CT) reconstruction is applied to PET imaging to recover fine features in this study. The proposed method starts with a constant initial image and the FR step is performed after each MLEM-TV iteration to extract the desired structural information lost during TV minimization. A feature descriptor is specifically designed to distinguish structure from noise and artifacts. A modified steepest descent method is adopted to minimize the objective function. After evaluating the impacts of different patch sizes on the outcome of the presented method, an optimal patch size of 7×7 is selected in this study to balance structure-detection ability and computational efficiency.

RESULTS:

Applying MLEM-TV-FR algorithm to the simulated brain PET imaging using an emission activity phantom, a standard Shepp-Logan phantom, and mouse results in the increased peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) as comparing to using the conventional MLEM-TV algorithm, as well as the substantial reduction of the used sampling numbers, which improves the computational efficiency.

CONCLUSIONS:

The presented algorithm can achieve image quality superior to that of the MLEM and MLEM-TV approaches in terms of the preservation of fine structure and the suppression of undesired artifacts and noise, indicating its useful potential for low-sampled data in PET imaging.
ТЕОРЕТИЧНІ АСПЕКТИ КОНКУРЕНТОСПРОМОЖНОСТІ БУДІВЕЛЬНОГО КОМПЛЕКСУ РЕГІОНУ
Authors: Колечков Д. В.
Published: July 2019

The article analyzes the main theoretical approaches to the competitiveness of the construction complex of the region. The concepts of competition, competitiveness, competitiveness of the region, competitiveness of the construction complex are given. The purpose of the research is the study of theoretical approaches and the definition of meaningful characteristics that accurately reveal the essence of the competitiveness of the construction industry. The object of the research is the priorities ensuring the competitiveness of the construction complex of the region. The hypothesis of the research - the specificity of the assessment of construction enterprises is determined by the characteristics of construction products as a commodity in the real estate market. Methods that were used in the study. The study used the methods of monographic, factor, correlation, interregional analysis, comparison, induction. The statement of basic materials. The basis of the competitiveness of the building complex is a system of motives, which are a powerful force inducing it to self-development and improvement. The system of motives stimulates the organization to change the mission and principles of management, the reengineering of business processes, the introduction of innovations, the quality management system, and the production of higher quality products. The originality and practical significance of the research. The given system of indicators for studying the potential of competitiveness with regard to statistics provides rich material for their analysis. In the conditions of constantly changing market conditions, the number of indicators characterizing competitiveness is decreasing, they are unified, some of them receive new economic content, some of them die out of uselessness, the development of a generalizing indicator for measuring competitiveness is becoming increasingly important. Conclusions of the research. Development of competitiveness potential development models based on statistical methodologies and techniques is one of the indispensable conditions for understanding market conditions, supply and demand trends and forecasting them, making optimal decisions at all levels of management leading to the growth of competitiveness of the regional economy.
ФОРМУВАННЯ ОБЛІКОВО-АНАЛІТИЧНОГО ЗАБЕЗПЕЧЕННЯ УПРАВЛІННЯ ПРИБУТКОВІСТЮ ПІДПРИЄМСТВ
Authors: Юрченко О. С.
Published: July 2019

The orientation to sustainable development of enterprises necessitates the formation of effective accounting and analytical system of profitability management. In this regard, the article is focused on the disclosure of priority areas for developing of theoretical and methodological foundations for formation accounting and analytical support for profitability management. The purpose of the research is the disclosure of current problems and priority areas of the formation of accounting and analytical support for the management of profitability of enterprises. The subject of the research is the theoretical and methodological foundations regarding the formation of the accounting and analytical system in the management of the profits of the enterprises. The object of research - the process of selection of priorities of accounting and analytical system in managing the profitability of enterprises. The methods, used in the research are scientific knowledge, induction, system analysis and conceptual synthesis. The hypothesis was assumption, in the conditions of increasing financial position of business entities, it is necessary the reorientation of the accounting and analytical system in order to identify the influence of factors on profits, reserves and ways of their mobilization for increasing the profitability of enterprises. The statement of basic materials. Based on the results of the research, the preconditions and problems of the development of the conceptual positions of the accounting and analytical support are determined and the ways of their solution are outlined. It is substantiated that the profit depends on the choice of methods of enterprise accounting policy and assessment procedures. It is proved that strategic management accounting is a component of the accounting and analytical system in managing profitability of enterprises. The sequence of formation of the concept of accounting and analytical support for profitability management of enterprises is disclosed. The originality and practical significance of the research is the disclosure of areas for developing of theoretical and methodical foundations of formation of the accounting and analytical system in the management of profitability of enterprises. Conclusions of the research. Introduction in practice of a strategically oriented accounting and analytical system provides the opportunity to assess the internal capacity of the formation of profitability of enterprises, on the one hand, and, on the other hand, the opportunity of generating the value of the enterprise for the future reserves.
НАПРЯМКИ ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ЛІСОВОГО КОМПЛЕКСУ СІЛЬСЬКИХ ТЕРИТОРІЙ РЕСПУБЛІКИ КОМИ
Authors: Носков В. А. , Шишелов М. А. , Дмитриева Т. Е.
Published: July 2019

The forestry complex plays an important role in the rural economy of the municipalities of the Komi Republic. However, due to the nature of the distribution of forest resources and types of forestry activities, its effectiveness and impact on the socio-economic development of territories is different. This provision actualizes the development of a methodology for evaluating the effectiveness of the forest complex in rural areas of the Komi Republic and proposals for directions and mechanisms for its improvement. The purpose of the research is to develop ways to improve the efficiency of the forest complex of rural areas of the Komi Republic. The object of the research is the methodology for assessing the efficiency of the forest complex in rural areas of the Komi Republic, as well as the directions for its improvement. The hypothesis of the research is to measure the effectiveness of the functioning of the forest complex of the region based on the structural-territorial differentiation of territories. The methods used of the research. The methodological features of the study are: structuring the efficiency of the forest complex on the production, socio-economic, spatial and bioeconomic; use of a set of indicators characterizing these aspects of efficiency; aggregation of indicators into group and final efficiency ratings by districts; analysis of the factors that determined the spatial differentiation of the efficiency of the forest complex. The statement of basic materials. As a result of a study on a structured set of indicators, a picture of the structural and territorial differentiation of the efficiency of timber industry activity was obtained, formed by the distribution of relevant indicators characterizing the influence of various factors using a rating score. The modern limitations of the development of the forest complex of municipalities of the republic with a rural economy are highlighted. The оriginality and practical significance of the research lies in the possibility of conducting a typology of rural areas according to the level of efficiency of the forest complex, as well as proposing directions and mechanisms for its improvement, applicable to each group of districts. Conclusions of the research. An integrated assessment of the efficiency of the forest complex of rural areas has allowed to identify areas with high, medium and low levels of efficiency, as well as a separate group of areas with “non-forest” specialization or with a weak forest industry. Prospects for the further use of the results obtained can be adjusted by the strategy of socio-economic development of territories, as well as new approaches to the location of productive forces in the North.
PENGELOLAAN MEDIA CERTA ANAK DALAM PEMBENTUKAN BUDI PEKERTI PESERTA DIDIK DI SEKOLAH DASAR
Authors: Sutarman Adang
Published: July 2019

Children's short stories are generally made by adults, contains a number of mandates that can be used as a tool of cultivation of character in students in primary schools. The intrinsic and extrinsic elements in the children's short story selected as teaching materials can be utilized as a medium of character teaching to the students in the elementary school. The best children's short story for children is a short story that gives children a place to look at their lives so as to broaden their insights and knowledge about the lives they live. Such short stories of children are included in the category of short stories that contain pedagogical values. Through the appearance of the characters, the children are enabled to identify the character and make the guidelines for behavior. Therefore, so that children are not wrong in identifying the characters in a story, it takes guidance and guidance from parents when at home and teachers when they are at school. However, sometimes teachers often find it difficult to choose a good child story. In choosing and presenting reading or stories for children, teachers must be selective. Teachers should be able to distinguish reading or a good story and worth reading or not by children.

Keywords. Short Stories of Children, Teaching Materials, Manners.
IMPLEMENTASI PROGRAM PENGEMBANGAN MUTU SARANA PRASARANA PERPUSTAKAAN MELALUI PENATAAN RUANG PERPUSTAKAAN SMAN 1 CIOMAS
Authors: Hasanah Suhriyatul
Published: July 2019

In an effort to support the implementation of excellent service or satisfactory then the library as an institution engaged in services need to pay attention to the necessary spatial arrangement in order to realize the prime or satisfactory conditions. Spatial design exist in the library needs to be designed specifically because it is different from the arrangement of space in general. In other words, a library should organize the library space as much as possible, so that the library visitors feel at home to linger in the library. With the arrangement of this library room in the library expected SMAN 1 Ciomas is more developed, as the foundation of educational institutions. This study aims to: 1) help develop the library space management SMAN 1 Ciomas 2) Knowing what constraints contained in the library 3) To increase knowledge, experience, recognition and observation. This research was conducted at a formal educational institution that is SMAN 1 Ciomas. The research method used is qualitative case study, respondents in this research is the head of library and librarian. The results of this study that the development of SMAN 1 Ciomas library has been there developments in the quality of infrastructure facilities through the arrangement of the library space.

Keywords. Quality Development, Infrastructure Facilities, and Library Spatial Planning.
MANAJEMEN BERBASIS SEKOLAH: STRATEGI ALTERNATIF DALAM PERSAINGAN MUTU
Authors: Ibrohim Busthomi
Published: July 2019

Politically, School Based Management (SBM) becomes the mouthpiece of all issues in the field of education that will be portrayed in schools, because the school is the last network of educational bureaucracy. SBM is also a form of operationalization of the decentralization or education autonomy policy in relation to regional autonomy. Theoretically, SBM is also a concept that offers autonomy to schools in order to improve quality, efficiency and equity of education in order to accommodate the interests of local communities as well as establishing close cooperation between schools, communities and governments. Operationally SBM is an idea that places the authority of school management in a system entity. Based on the above view, this article outlines the basic framework of SBM as a strategy for improving the quality of education. With SBM, principals, teachers and learners get the opportunity to innovate and improvise in schools related to curriculum, learning, managerial and others. So the principal serves as an educator, manager, administrator, supervisor, leader, innovator, motivator, figure, and mediator. SBM also calls for the creation of new institutional arrangements and institutions, including: the establishment of school boards, development of school strategy planning, develop of annual school planning, internal monitoring and self-assessment, annual reporting, school opinion surveys of school stakeholders.

Keywords. School Based Management, Decentralization of Education, Quality Assurance, Autonomy of Education, School Committee
HUBUNGAN KEPEMIMPINAN PENGAJARAN KEPALA SEKOLAH DAN DISIPLIN KERJA GURU TERHADAP PRESTASI AKADEMIK SISWA
Authors: Supriadi Eddi , Awang Marinah Binti
Published: July 2019

This study aims to know and analyze the relationship of leadership principal teaching and work discipline to student academic achievement in school. This research uses quantitative method, the data is analyzed by using descriptive statistic and inference. Data collection using instruments, instruments compiled from various sources tailored to the research method used. The study was conducted on teachers in elementary schools in Jakarta. The study shows that there is a positive and significant correlation between the principal's teaching leadership and the students 'academic achievement with the correlation correlation value of 0.454, there is a significant correlation between the teacher's work discipline with the students' academic achievement with the correlation value of 0.576. From the results of the study can be concluded that the improvement and improving the quality of student achievement can be done with the improvement and improvement of the leadership quality of teaching the principal and the discipline of teacher work. Student achievement can develop well with the help and touch of a principal through good school management, as well as the discipline of a teacher in carrying out his work as an educator so that will provide a good quality of learning process also with the expected achievement of student learning achievement high in school.

Keywords. Leadership Teaching, Principals, Teachers Dicipline, Academic Achievements.
KEPEMIMPINAN PROFETIK DALAM PERSPEKTIF MANAJEMEN PENDIDIKAN ISLAM
Authors: Wasehudin Wasehudin
Published: July 2019

Leadership is the main pillar in organizing an organization. The success of Islam as a divine religion will no be separated from the personality of a figure who has high integrity and capability. Muhammad as a figure, the Prophet and the Apostle is a rule model in managing (designer) teliabel all forms of life from family, community to head of state. In Jalaluddin Rachmat’s pint of view there are two forms in dealing with Islam: both textual and the second contextual. The conceptual Islam is Islam contained in the Qur’an as a revelation whose truth will be left when the interpreters are able to understand it in the present context. While the actual Islam is a smart and brilliant idea how to display the figure of Islam is cool, harmonious, and full of peace. Showing such Islam is an unattached portion of a reliable managerial figure in which the pattern of enforcement of juistice as the basis of the all-embracing idealism has been termed by Kunto Wijoyo in which the managerial arrangement of social, political, managerial directed to a transformative order in which Islam and management constitute a united whole in order to organize social life.

Keywords. Leadership, Islam, Education, Prophetic.
KONTRIBUSI EFEKTIVITAS MANAJEMEN EKSTRAKURIKULER TERHADAP PRESTASI SEKOLAH NON AKADEMIK
Authors: Astafiyah Astafiyah
Published: July 2019

The objectives of this study are (1) to describe the level of extractive management effectiveness in Serang Junior High School 18; (2) to describe how much non-academic school achievement; (3) describes how much extracurricular non-academic school achievements. The research method used in this study is a quantitative method, with a correlational approach. The population in this study were students who took extracurricular activities as many as 120 students, thus the study sample was 30 respondents. The data collection techniques used a questionnaire. The conclutions of the research results are (1) the level of extracurricular management effectiveness at Serang Junior High School 18 is classified as good with 59.19%; (2) the level achievement of non-academic schools in Serang Junior High School is classified as good with 63.41%; and (3) the contributions of the effectiveness of extracurricular management variables on the achievement of non-academic school at 38.44%.

Keywords. Effectiveness, extracurricular management, non-academic achievements.
KEPEMIMPINAN KEPALA MADRASAH DALAM MENINGKATKAN ETOS KERJA GURU PADA MTs PONDOK BESAR ROUDLOTUL MUBTADIIN BALEKAMBANG NALUMSARI JEPARA TAHUN PELAJARAN 2017/2018
Authors: Rouf Abdur
Published: July 2019

Abstrak. Penelitian ini bertujuan: 1) untuk menganalisis kepemimpinan kepala madrasah di MTs Pondok Besar Roudlotul Mubtadiin Balekambang, 2) untuk menganalisis etos kerja guru di MTs Pondok Besar Roudlotul Mubtadiin Balekambang, dan 3) untuk menganalisis faktor penunjang dan penghambat etos kerja guru di MTs Pondok Besar Roudlotul Mubtadiin Balekambang. Penelitian ini adalah penelitian kualitatif (studi kasus). Instrument penelitian dengan menggunakan panduan observasi dan pedoman wawancara. Teknik pengolahan dan analisis data dilakukan dengan melalui tiga tahapan, yaitu reduksi data, penyajian data, serta penarikan kesimpulan dan verifikasi data. Hasil penelitian menunjukkan 1) Kepemimpinan Kepala MTs Pondok Besar Roudlotul Mubtadiin Balekambang cukup baik karena menjunjung tinggi tanggung jawab dengan penuh amanah, 2) Etos kerja guru MTs Pondok Besar Roudlotul Mubtadiin Balekambang dikategorikan baik, karena mereka telah memperlihatkan kinerja dan berbagai macam usaha yang dilakukan demi tercapainya tujuan pembelajaran, 3) Faktor penunjang  etos kerja (kedisiplinan, kepribadian guru melaksanakan tugas, keteladanan dan ketegasan kepala sekolah. Faktor Penghambat, terlihat masih banyak guru yang mengajar secara biasa, yakni dengan metode ceramah saja, sehingga minat siswa untuk belajar secara serius berkurang.

Kata Kunci.  Kepemimpinan, Kepala Madrasah, Etos kerja, Guru