bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Serum Pharmacochemistry, Network Pharmacology, and Molecular Docking to Study the Mechanism of Rhubarb against Atherosclerosis
Authors: Cai Zhi-Yan , Li Shu-Jiao , Wang Yu-Qing
Published: June 2024

Background:

Atherosclerosis (AS) is a chronic inflammatory disease characterized by
the accumulation of lipids, the formation of lesion plaques, and the narrowing of arterial lumens.
Rhubarb has significant effects against AS, but there is a lack of analysis and exploration of the
mechanism of action of the transitional components in serum containing rhubarb.

Objective:

This work aims to combine serum pharmacochemistry, network pharmacology, and
molecular docking to explore active ingredients and mechanism of rhubarb against AS.

Method:

Firstly, the components of rhubarb in blood samples were identified using HPLC-QTOF/
MS. The ingredients-targets-disease interaction network of rhubarb was constructed
through network pharmacology. Then, molecular docking between the ingredients and the core
targets was carried out using the Autodock Vina software.

Results:

Eleven active ingredients and five metabolites were preliminarily identified. The network
pharmacology results showed that chrysophanol, resveratrol, and emodin might have potential
pharmacological effects on AS. The PPI network showed that the key proteins were
PTGS2, ESR1, PTGS1, and ELANE. GO analysis revealed that genes were mainly enriched in
the inflammatory response and response to exogenous stimuli. Moreover, these genes were related
to IL-17 signaling pathways, lipid and atherosclerosis, and other pathways. Molecular docking
analyses showed that chrysophanol and emodin have strong binding affinities with the target
proteins PTGS2 and PTGS1.

Conclusion:

A comprehensive strategy combining serum pharmacochemistry with network
pharmacology and molecular docking was employed to investigate the active ingredients and the
mechanism of rhubarb in treating AS, which provided a basis for studying the pharmacological
effects and action mechanisms of rhubarb.
Hypertensive Crisis Associated with Serotonin Syndrome Following Linezolid Administration: Report of Two Cases
Authors: Shahbazi Foroud , Shojaei Lida
Published: June 2024

Introduction:

Serotonin syndrome is a potentially life-threatening condition that can
occur as a result of the therapeutic use of serotonergic medications or drug interaction. In this
study, we describe two cases of serotonin syndrome-associated hypertensive crisis following
linezolid use.

Case Presentation:

The first patient was a 52-year-old female who was admitted due to a diabetic
foot infection and pneumonia associated with a decreased consciousness level. Serotonin syndrome
occurred 24 hours after starting the linezolid use. Resistant hypertension was the main
hemodynamic finding. It could not be controlled with amlodipine, valsartan, prazosin, and nitroglycerin
infusion. Resistant hypertension and other symptoms of serotonin syndrome were resolved
about 48 hours after discontinuation of linezolid use.
The second case was a man with a history of kidney transplant, diabetes, and hypertension. He
was admitted to the ICU due to severe COVID-19 broad-spectrum antibiotics [linezolid,
cefepime], and remdesivir was initiated. Following intubation, continuous infusion of fentanyl
was used for sedation. Within 24 hours after fentanyl and linezolid initiation, severe agitation,
eye clonus, hyperreflexia, hypertension [160-186 /90-110 mmHg], and tachycardia [>100/min]
were noted. With the possible diagnosis of serotonin syndrome, fentanyl was discontinued, and
morphine was initiated. The patient’s symptoms improved 48 hours after discontinuation of fentanyl.

Conclusion:

Both of the patients had a history of controlled hypertension. However, serotonin
syndrome occurred following the use of linezolid and concomitant/recent use of serotonergic
agents. A thorough evaluation of the patient’s medical history and current situation can help clinicians
prevent this syndrome in critically ill patients.
Lysosomal Channels as New Molecular Targets in the Pharmacological Therapy of Neurodegenerative Diseases via Autophagy Regulation
Authors: Tedeschi Valentina , Sapienza Silvia , Ciancio Raffaella , Canzoniero Lorella Maria Teresa , Pannaccione Anna , Secondo Agnese
Published: June 2024

Besides controlling several organellar functions, lysosomal channels also guide the catabolic
“self-eating” process named autophagy, which is mainly involved in protein and organelle quality
control. Neuronal cells are particularly sensitive to the rate of autophagic flux either under physiological
conditions or during the degenerative process. Accordingly, neurodegeneration occurring in Parkinson’s
(PD), Alzheimer’s (AD), and Huntington's Diseases (HD), and Amyotrophic Lateral Sclerosis
(ALS) as well as Lysosomal Storage Diseases (LSD) is partially due to defective autophagy and
accumulation of toxic aggregates. In this regard, dysfunction of lysosomal ionic homeostasis has been
identified as a putative cause of aberrant autophagy. From a therapeutic perspective, Transient Receptor
Potential Channel Mucolipin 1 (TRPML1) and Two-Pore Channel isoform 2 (TPC2), regulating
lysosomal homeostasis, are now considered promising druggable targets in neurodegenerative diseases.
Compelling evidence suggests that pharmacological modulation of TRPML1 and TPC2 may rescue
the pathological phenotype associated with autophagy dysfunction in AD, PD, HD, ALS, and LSD.
Although pharmacological repurposing has identified several already used drugs with the ability to
modulate TPC2, and several tools are already available for the modulation of TRPML1, many efforts
are necessary to design and test new entities with much higher specificity in order to reduce dysfunctional
autophagy during neurodegeneration.
Analysis of Defects in Microscopic Images of Hetero Epitaxial Growth Technique Using Fuzzy K Means Clustering Algorithm
Authors: Kumar S. N. , Nagarajan M. , Shanmugan S. , Kumar H. Ajay
Published: June 2024

The semiconductor material InP plays a key role in optoelectronic devices,
high-speed devices, and fiber optic communications systems. The major problems with
these materials are the high lattice mismatch and variance in thermal expansion
coefficient between InP and Si. This mismatch produces high dislocation density at the
interface and the propagation of the threading dislocations away from the interface into
the device layer is a major concern in optoelectronic applications. Image processing
algorithms play a pivotal role in the medical field, archaeology, and remote sensing.
This work proposes an image processing method to analyze the SEM images of the InP
heteroepitaxy layer to determine the etch pits to confirm whether the substrate is
suitable for optoelectronic applications. In this work, a variant of an anisotropic
diffusion filter for noise reduction on SEM images and Fuzzy C means clustering
method for image segmentation was employed for analysis.
Study of groundwater contamination and its Impact: a Review
Authors: Ganesan Subbulakshmi , Mirle Rekha , Kallumpurat Akhilesh , Vijayan Ashwathi , Christal K. Gloria
Published: June 2024

The groundwater cycle is one of the most vital elements of life. This is the
sole cardinal provenance of potable agricultural and industrial water. Underground
water may be of good quality for cooking and drinking (potable) or it can be medium
quality (domestic and industrial) or have another inappropriate quality for any use due
to various contaminations. Heavy metals, minerals, and other factors can be present in
the water. Septic systems can be contaminated by natural and artificial sources. There
are many artificial polluting sources, such as chemicals, fertilizers, and mining
activities, and there are also natural ones, such as seawater intrusion, geothermal brine
seepage, and rock water leaching. Health hazards are associated with contaminated
water. Groundwater contamination can lead to degrading surface water systems, loss of
water supply, poor quality, or even no, and drinking water. It is well known that water
is an essential part of life, and all animals, including humans, need water in order to
persist. Throughout this paper, we have examined the health effects, environmental
impacts, and prevention of groundwater contamination.
Molecular Biodiversity of Rhizobia Isolated from Root Nodules of Some Economical Important Legumes in Gadarif State – Sudan
Authors: E. Suleiman Abdel Moneim
Published: June 2024

Although Gadarif State is an important agricultural area in Sudan, studies must be conducted on rhizobia’s genetic or molecular diversity associated with economically important legumes. Therefore, this study was undertaken to isolate rhizobia related to groundnut (Arachis hypogea), Bambara groundnut (Vigna subterranean), and Cowpea (Vigna unguiculata) in different localities in Gadarif State and study their phylogenetic relationships to make the genetic information of the indigenous rhizobia available and establish a molecular database for monitoring future climate change impact on their diversity. Nodules were collected from 11 localities of the Gadarif state, rhizobia were isolated, DNA was extracted, 16SrRNA, recA, glnII, nifH, and nodA genes were amplified, and data were analyzed. The results showed that all isolates obtained from six localities were found to be fast-growing. Isolates obtained from groundnut nodules are Rhizobium sp._Haw1 and Rhizobium sp._G6-11, which are found to be related to Rhizobium leguminosarum. These two strains were found to be associated with Rhizobium etli when BLASTN analyzed the sequences. At the same time, Rhizobium sp._UoG27, which was isolated from the same plant, was found to be related to Rhizobium tropici. There is evidence of new species in Rhizobium sp._UoG30, Rhizobium sp._Sab13 (isolated from Bambara groundnut), Rhizobium sp._Umk34 (isolated from Cowpea), and Rhizobium sp._Taw3 (isolated from groundnut). No symbiotic genes (nifH and nod) were found in all isolates except the strain isolated from Alfalfa grown in Gezira state (Central Sudan). The study concluded that fast-growing rhizobia are dominant in Gadarif state soils, characterized by genetic instability, and may play roles other than nitrogen-fixing.
Evaluation of BHMT2 Gene Expression and its Expression Factor Regulating LNC00922 LNCRNA with rs10944 Genotype Determination in Patients with Breast Cancer
Authors: Zavareh Seyed Ali Dibaj
Published: June 2024

It is predicted that dysregulation of BHMT2 expression level could have a remarkable effect on Breast cancer status. The absence of methionine and Hyperhomocysteinemia have been linked to a decline in BHMT2 expression. This mRNA expression and its correlated long non- coding RNA (lncRNA) (LINC00922) have been investigated in our experiment based on the bioinformatics approach. Also, the genotype frequency analysis of BHMT2 in SNP rs10499 has been demonstrated. The mentioned SNP is correlated with the differences in the binding affinity of miR542-3p. We performed a microarray analysis to find the differentially expressed genes (DEGs). GeneMANIA and miRWalk online databases were used for mRNA-mRNA and mRNA-miRNA interaction analyses. Clusterprofiler package was used for functional and pathway enrichment analyses. dbSNP database was applied for finding the relevant Single nucleotide polymorphism (SNP). The Co-lncRNA database was used for finding the correlated lncRNA.A real-time PCR experiment was performed to count the relative expression level of BHMT2 and LINC00922. The high resolution melt (HRM) method was performed to identify the SNP genotype frequency.BHMT2 had a significant down-regulation, and LINC00922 had a significant up-regulation in Breast cancer tissues compared to normal. No significant difference in genotype frequency of rs10944 was observed. The current study revealed that BHMT2 and LINC00922 can be the two novel correlated biomarker of breast cancer. More similar investigations are needed for evaluating more accurate and reliable result, specially about rs10499.
Kajian musikologis “Ya’ahowu” movement pertama dalam “Moroi ba danö niha numalö ba danö jawa” musik program budaya Nias
Authors: Zega Venti Krisdayanti , Untung Rachel Mediana , Ruswanto Yohanes
Published: June 2024

Studi ini dilakukan dalam ranah penciptaan karya komposisi musik yang menceritakan tentang kehidupan penulis berdasarkan budaya sendiri (Nias). Sejalan dengan proses penciptaan itu, penulis menceritakan proses penyusunan karya dan menganalisis karya tersebut. Metode penelitian ini menggunakan studi pustaka, penelitian kualitatif dan melakukan analisis menggunakan pendekatan musikologi. Selain menggunakan studi pustaka, pengumpulan data  yang dilakukan didasarkan dari beberapa artikel jurnal dari hasil wawancara dan observasi.  Hasil penelitian ini menunjukkan bahwa proses cipta dari karya yang disusun menggunakan empat tahapan kreasi dan analisis struktural dari karya yang disusun terbagi menjadi enam bagian. Proses kreatif pada karya yang telah disusun didasarkan atas pengalaman empiris dari penulis kemudian untuk analisis struktural dari karya ini merupakan bagian dari proses penciptaan komposisi yang sudah dibagi menjadi beberapa bagian untuk mempermudah analisis dari karya ini. Tulisan ini menyarankan perlunya berbagai sumber informasi yang lebih luas yang diteliti dalam penambahan sumber data untuk memungkinkan karya yang disusun dapat dipahami oleh masyarakat. Kata kunci: Musik program, budaya Nias, proses kreatif, pengalaman empiris, analisis struktural The musicological study of the “Ya’ahowu” movement in “Moroi ba danö niha numalö ba danö jawa” Nias cultural music program AbstractThis study is conducted in the realm of creating musical compositions that narrate the author’s life based on their own culture (Nias). Along with the creative process, the author describes the process of composing the work and analyzes the composition. This research employs literature review, qualitative research, and analysis using a musicological approach. In addition to the literature review, data collection is based on several journal articles from interviews and observations. The findings of this research show that the creation process of the composition follows four stages of creation, and the structural analysis of the composition is divided into six sections. The creative process of the composition is based on the author’s empirical experiences. The structural analysis of the composition is part of the creation process, divided into several parts to facilitate the analysis of the work. This paper suggests the need for a wider range of information sources to be examined in the addition of data sources to enable the composition to be understood by the public. Keywords: Music program, Nias culture, creative process, empirical experience, structural analysis
Impact of price fairness, service quality, and destination image on tourist loyalty and satisfaction: A case study of Lake Toba, North Sumatra
Authors:   Management Doctoral Program, Universitas Prima Indonesia, North Sumatera Medan, Indonesia, Marpaung Halimatu Saddiah , Syaifuddin Syaifuddin ,   Management Doctoral Program, Universitas Prima Indonesia, North Sumatera Medan, Indonesia, Toni Nagian ,   Management Doctoral Program, Universitas Prima Indonesia, North Sumatera Medan, Indonesia
Published: June 2024

Tourist loyalty is crucial for enhancing the well-being of local communities in a region. This study aims to investigate how price fairness, service quality, destination image, and tourist facilities directly and indirectly affect tourist loyalty via tourist satisfaction at Lake Toba, North Sumatra. A quantitative method was utilized for this research. The study focused on tourists who visited Lake Toba in 2022, totaling 179,609 individuals. A sample of 280 tourists was selected using an accidental sampling method, where tourists were chosen randomly. The data collection was conducted through questionnaires based on specific indicators for each variable studied. The data was analyzed using the Structural Equation Model (SEM) technique, employing the Partial Least Square (PLS) method. The findings reveal that tourist satisfaction plays a significant role in mediating the impact of price fairness, service quality, destination image, and tourist facilities on loyalty to Lake Toba, both directly and indirectly. The results indicate that price fairness is the most critical factor for tourists when considering returning to Lake Toba. This study suggests that there should be an authority responsible for ensuring price fairness in tourism services and products at Lake Toba to maintain and improve tourist loyalty.
A survey of classification cache replacement techniques in the contentcentric networking domain
Authors:   Department of Information Technology, Faculty of Computing and Information Technology, University of Sargodha, Sargodha, Pakistan, Batool Sidra , Kaleem Muhammad ,   Department of Information Technology, Faculty of Computing and Information Technology, University of Sargodha, Sargodha, Pakistan, Rashid Salman ,   Department of Computer Science and Information Technology, University of Lahore, Lahore, Pakistan, Mushtaq Muhammad Azhar ,   Department of Information Technology, Faculty of Computing and Information Technology, University of Sargodha, Sargodha, Pakistan, Khan Iqra ,   Department of Information Technology, Faculty of Computing and Information Technology, University of Sargodha, Sargodha, Pakistan
Published: June 2024

Content-Centric Networking (CCN) is an innovative approach that emphasizes content. A key strategy in CCN for spreading data across the network is in-network caching. Effective caching methods, including content placement and removal tactics, enhance the use of network resources. Cache replacement, also known as content eviction policies, is essential for maximizing CCN's efficiency. When cache storage is full, some content must be removed to make room for new items due to limited storage space. Recently, several advanced replacement strategies have been developed to determine the most suitable content for eviction. This study categorizes the latest cache replacement strategies into various groups such as static, space scarcity, content update, centralized, energy-efficient, weighted, adaptive, and based on dynamic popularity. These categories are based on the approaches suggested in previous research. Additionally, this paper provides a critical analysis of existing methods and suggests future research directions. To the best of our knowledge, this is the most up-to-date and comprehensive review available on this topic.
Blockchain Technology and Corporate Governance: An Analysis of Board Structure, Shareholder Rights and Compensation Policies
Authors: Abida Maher
Published: June 2024

The blockchain technology (BT)_offers a new means to trade and monitor the ownership of financial assets which is similar to the advent of double-entry bookkeeping centuries ago. This represents a significant development in financial record-keeping. Stock exchanges are investigating BT worldwide to enable businesses to list, to trade and to vote on shares. This adoption has the potential to benefit stockholders through reduced trading costs, faster ownership transfers, improved record accuracy and increased process transparency. This study examines the effect of BT on corporate governance. Using feasible generalised least squares analysis, our study analyses data from 297 European businesses included in the STOXX Europe 600 index between 2016 and 2021. The results show that the adoption of BT improves the quality of board decision-making and streamlines board activities. In addition, the study indicates that BT facilitates greater direct shareholder rights and encourages effective worldwide administration of director and board member compensation. The research contributes to the current body of literature by confirming the positive impact of implementing (BT) on enhancing corporate governance measures. This, in turn, assists managers in formulating appropriate strategies.
Investors Perception Towards the Initial Public Offering of Startup Companies
Authors: B Bharathi , K R Gopala
Published: June 2024

The study examines the level of awareness among the investors about startup IPOs and analyses the relationship between independent variables such as size and purpose of IPO, company profile, financial performance, quality management and sector performance and investment decision in startup IPO which is the dependent variable. The research is conducted majorly using primary data collected from 360 two respondents across the state of Karnataka. The data so collected is analysed using the SPSS software. The statistical tools like multiple regression analysis and correlation analysis are used to analyse the data and hypothesis are tested using ANOVA. Five hypotheses were framed and tested to verify the effect of five independent variables on dependent variable. The outcome of the study reveals that, majority of the investors have awareness about the startup IPOs and size and purpose of IPO, company profile, financial performance, quality management and sector performance have positive relationship with dependent variable and these factors have highly considerable impact on investment decision in startup IPO in Indian stock market. This study concludes that 96.1% of the investment decision in startup IPO is influenced by the sector performance, financial performance, size & purpose of IPO, quality management and company profile.
Non-Linear Relationship between Bond Prices and Electricity Prices in India: An Analysis using Threshold Regression Approach
Authors: Thomas Robin
Published: June 2024

This research article scrutinises the connotation among bond prices and electricity prices (EP) across different threshold regions in India using threshold regression analysis. We resolve to investigate whether or not there exists a non-linear association between bond prices and EP and if this relationship differs across different threshold regions. The data covers a period of five years from 2018 to 2022, and the analysis includes three different threshold regions based on different threshold bond prices. The results show that there exists significant non-linear association between bond prices and EP, and this relationship differs across the three threshold regions. We surmise presence of an optimality between bond prices (interest rates) and EP, beyond which the EP increase. We conclude that as interest rates increase, the cost of financing for electricity companies also increases, which may lead to higher EP. However, there may be a certain threshold beyond which the cost of financing becomes too high, leading to a decrease in investment and ultimately a decrease in electricity supply, which in turn could lead to higher EP.
Using real Electronic Health Records in undergraduate education: a promising future or logistical nightmare? (Preprint)
Authors: Nadeem Fatima , Azmy Jessica , Shomali Asieh Yousefnejad , Diette Benjamin , Gregory Lloyd J , Davies Angela C , Wilson Kurt C
Published: June 2024

BACKGROUND

Simulated electronic health records (EHRs) are used in structured teaching for healthcare students. In part, this addresses inconsistent student exposure to, and participation with EHRs whilst on clinical placements. However, simulated records are poor replacements for the complexity and volume of data encountered in real EHRs. Whilst routinely collected healthcare data is often used for research, secondary use does not extend to education. Within our project we are exploring the perceptions, governance and ethics required to support the use of donated real patient records within teaching.

OBJECTIVE

To explore the perspectives of healthcare professionals regarding the use of real patient records to deliver interprofessional EHR education to undergraduate healthcare students.

METHODS

We held 90-minute group discussions with ten healthcare professionals from nursing, pharmacy, medicine, and allied health disciplines.

RESULTS

There was consensus on the need to upskill healthcare students in the use of EHRs. Participants emphasised the value of teaching general EHR competencies and transferable skills to overcome the diversity in EHR systems. They highlighted key limitations in current EHR teaching due to accessibility issues, disparities within clinical teaching and curricular gaps on important topics such as clinical documentation and coding. Highlighted benefits of real EHRs in structured teaching included learning from the complexities and inaccuracies of real patient data, grasping real-world timeframes and better appreciation of multidisciplinary interactions. Concerns included exposing individual clinicians to unfounded scrutiny as well as the potential consequences of incidental findings within EHRs. The ethical implications of overlooking perceived errors within EHRs versus the impracticality of acting on these findings were discussed in detail. To mitigate concerns, it was suggested that data donors would be clearly informed and consented ensuring they understand that they will not be re-contacted should any such errors be found.

CONCLUSIONS

Innovative solutions are needed to re-align healthcare education with clinical practice in rapidly evolving digital environments. Real patient records are the best resource for teaching students to competently handle complex and abundant real-world data. Our reflections highlight the processes and safeguards to consider when using real patient records to deliver EHR education to healthcare students.
Effects of an 8-week app-based mindfulness intervention on mental health in working women: A randomized controlled trial (Preprint)
Authors: Uwagawa Riko , Adachi Koichiro , Shimoda Mariko , Takizawa Ryu
Published: June 2024

BACKGROUND

Although working women experience increased work-related stress, preventive interventions to reduce its negative effects on their mental health are insufficient.

OBJECTIVE

This study evaluated the effectiveness of an 8-week mindfulness-based self-help intervention via a smartphone application across four domains (general psychological, work-related, family-related, and work-to-conflict) among working women.

METHODS

This study recruited women workers via various media sources, such as crowdsourcing sites and social networking services. Participants were randomly assigned to the intervention (n=106) or waitlist control groups (n=107). Participants in the intervention group practiced guided mindfulness meditation every day at their convenience via an app on their cell phones for eight weeks. The app provides an 8-week program with four meditation contents per two weeks. Participants in the waitlist control group lived as usual for eight weeks. We conducted web-based questionnaires to assess participants’ general psychological (life satisfaction, perceived stress, depressive and anxiety symptoms, trait anger, mindfulness), work-related (work performance, job satisfaction, quantitative job overload, job control), family-related (family satisfaction, partner satisfaction), and work-to-family conflict indicators.

RESULTS

An analysis of covariance, controlled for pre-intervention scores, revealed that the intervention significantly increased life satisfaction (b=1.47, β=0.11, P=.005) and decreased perceived stress (b=-2.00, β=-0.17, P=.012), depressive and anxiety symptoms (b=-1.24, β=-0.15, P=.02), and trait anger/reaction (b=-0.59, β=-0.11, P=.04). The intervention group demonstrated significantly increased life satisfaction (t93=-3.36, P=.001) and decreased depressive and anxiety symptoms (t93=2.35, P=.02).

CONCLUSIONS

The app was effective in reducing perceived stress, depressive and anxiety symptoms, and trait anger/reaction, and in improving life satisfaction among working women. However, to improve work- and family-related indicators, higher-intensity interventions may be required, such as modifying the intervention content or extending its duration.

CLINICALTRIAL

University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) UMIN000051796; https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000059110.
Averaged versus Persistent Reduction in Urine Output to Define Oliguria in Critically Ill Patients
Authors: Monard Céline , Bianchi Nathan , Kelevina Tatiana , Altarelli Marco , Chaouch Aziz , Schneider Antoine
Published: June 2024

Key Points

When assessing urine output, consideration of an average or persistent value below a threshold has important diagnostic and prognostic implications

Seventy-three percent (95% confidence interval, 72.3 to 73.7) of patients had oliguria by the average method versus 54.3% (53.5 to 55.1) by the persistent method.

Background

Oliguria is defined as a urine output (UO) of <0.5 ml/kg per hour over 6 hours. There is no consensus as per whether an average or persistent value should be considered.

Methods

We analyzed all adults admitted to a tertiary intensive care unit between 2010 and 2020, except those on chronic dialysis or who declined consent. We extracted hourly UO and, across 6-hour sliding time windows, assessed for the presence of oliguria according to the average (mean UO below threshold) and persistent (all measurements below a threshold) methods. For both methods, we compared oliguria's incidence and association with 90-day mortality and acute kidney disease at hospital discharge.

Results

Among 15,253 patients, the average method identified oliguria more often than the persistent method (73% [95% confidence interval, 72.3 to 73.7] versus 54.3% [53.5 to 55.1]). It displayed a higher sensitivity for the prediction of 90-day mortality (85% [83.6 to 86.4] versus 70.3% [68.5 to 72]) and acute kidney disease at hospital discharge (85.6% [84.2 to 87] versus 71.8% [70 to 73.6]). However, its specificity was lower for both outcomes (29.8% [28.9 to 30.6] versus 49.4% [48.5 to 50.3] and 29.8% [29 to 30.7] versus 49.8% [48.9 to 50.7]). After adjusting for illness severity, comorbidities, age, admission year, weight, sex, and AKI on admission, the absolute difference in mortality attributable to oliguria at the population level was similar with both methods (5%). Similar results were obtained when analyses were restricted to patients without AKI on admission, with documented body weight, with presence of indwelling catheter throughout stay, and who did not receive KRT or diuretics.

Conclusions

The assessment method of oliguria has major diagnostic and prognostic implications. Its definition should be standardized.
Cross-Cultural Art from the Perspective of Aesthetic Education: Cultural Exchange in Chinese Export Paintings (18th - 19th Century)
Authors: Fan Xiaobing
Published: June 2024

During the late Ming to early Qing dynasties, the great demand for Chinese export porcelain laid the foundation for the development of export paintings. From the 18th to the 19th century, a unique form of cultural hybridity emerged in the coastal area of Canton: export paintings. This paper attempts to explore the interaction, conflict, and fusion with foreign cultures within the frameworks of Homi Bhabha's "third space" theory and Mary Louise Pratt's concept of the "contact zone." It examines how this cross-cultural art form manifests hybridity in materials, painting techniques, and themes.From the perspective of aesthetic education, these paintings provide profound insights into the cultivation of aesthetic sensibilities and cross-cultural appreciation. Predominantly produced by Chinese painters and workshops, with a few contributions from visiting European painters, these artworks cover a broad range of subjects, including Chinese social life, flora and fauna, and folk customs. By examining the aesthetic value and educational potential of these works through the lens of aesthetic education, we can better understand their significance in cross-cultural art exchange. This cross-cultural art form not only holds aesthetic importance but also provides a new perspective for studying Sino-Western cultural interactions, enriching the discourse on art education and cultural exchange.
Strategies for Applying Machine Translation in MTI Translation Teaching
Authors: Dan Shuying , Bai Yangming
Published: June 2024

Machine Translation (MT) should be integrated into Master of Translation and Interpreting (MTI) translation teaching more intelligently. This study focuses on the practical application of MT in MTI translation teaching, aiming to overcome challenges such as the rigidity in traditional teaching models, the monolithic methods for translation quality assessment, and the shortage of qualified teachers. Through an analysis of the current status of MTI translation teaching, this paper proposes strategies like utilizing MT for multi-modal teaching, conducting post-translation quality assessment training with MT, and implementing teacher training with MT tools. The results indicate that these strategies not only significantly improve teaching quality and efficiency but also promote innovation in teaching models. This paper offers novel insights into the MTI translation teaching method and provides solid support for the deep integration of MT with educational practice, thereby ushering in an important pathway for cultivating outstanding translation talents in the new era.
Establishing Water Buffaloes as a Promising Source of Red Meat in Pursuit of Sustainable Animal Proteins for a Better World
Authors: Maheswarappa Naveena B. , Mohan Kiran , Banerjee Rituparna
Published: June 2024

Water buffaloes (Bubalus bubalis) are distributed in 46 countries across 5 continents and hold significant importance within the livestock production system in various South Asian countries. Water buffaloes are native to Asia and Mediterranean regions and have a significant impact on the economic profitability of producers due to their valuable contributions through milk, meat, leather, and draught power. The production of buffalo meat plays a significant role in safeguarding global food security by meeting the growing demand for high-quality proteins. Buffaloes provide consumers with an unmatched blend of low-fat, low-cholesterol, conjugated linoleic acid and other bioactive peptide-rich meat with a lower atherogenic index and health advantages. Multiple utility, climate-smart nature, reduced food miles, suitability under a small-holder production system, and contribution to UN Sustainable Development Goals promise water buffaloes as a sustainable source of red meat. This comprehensive depiction emphasizes the pivotal position that buffaloes are expected to assume in the future of meat technology. The current review serves as an essential reference for stakeholders engaged in the dynamic domain of buffalo meat production, processing, import and export agencies, standard-setting bodies, and policymakers.
MÍDIA-EDUCAÇÃO: O MODO COMO NÓS INTERPETAMOS O MUNDO E COMO OS OUTROS INTERPRETAM O MUNDO POR NÓS
Authors: Vieira Fábia Magali Santos , Soares dos Santos Ana Clara , Santos César Maria Fernanda , Maia Veloso Maria Jacy
Published: June 2024

O presente artigo apresenta uma reflexão, a partir da discussão sobre mídia-educação, acerca da relação entre os futuros professores da educação básica e a mídia. Participaram deste estudo 19 acadêmicos matriculados na disciplina Tecnologia Aplicada à Educação, no 7º período do curso de Pedagogia, da Universidade Estadual de Montes Claros – Unimontes, vespertino, 1º semestre de 2021, realizado remotamente, on-line, com atividades síncronas e assíncronas. Partindo da discussão sobre os “conceitos-chave”: linguagem, audiências, instituições de mídia e representação (Siqueira, 2013) para análise da mídia-educação na formação inicial de professores em um diálogo com os fundamentos da democracia, da negociação de sentidos e da multimodalidade. Os resultados evidenciam que a realização de somente uma leitura superficial dos textos midiáticos durante as atividades, sem analisar o contexto no qual foram produzidos não é suficiente para se fazer uma leitura crítica da mídia, sendo assim é importante que os acadêmicos de um curso de licenciatura tenham acesso a uma diversidade de fontes de informação, criando possibilidades de ampliarem a bagagem cultural, a fim de que se tornem usuários críticos e criativos da mídia e não apenas meros consumidores.
MINORIAS ATIVAS E AS REPRESENTAÇÕES SOCIAIS DA INDISCIPLINA ESCOLAR
Authors: Charles Ferreira Adriano , José Rosso Ademir
Published: June 2024

O artigo descreve as representações sociais dos estudantes do 9° ano sobre a indisciplina escolar. Os aportes teóricos utilizados foram as representações sociais (Moscovici, 2012), minorias ativas (Moscovici, 2011) e o desenvolvimento moral (Piaget, 1994). A metodologia quanti-qualitativa, com uso do software Alceste e posterior análise de conteúdo. As informações foram coletadas em duas etapas: a) entrevista (N=45) a estudantes de três colégios estaduais públicos da cidade de Ponta Grossa-PR; b) entrevista (N=07) a estudantes que se destacaram com características de minorias ativas do total de entrevistados, ambas seguindo roteiro com triagens hierárquicas sucessivas mediada por cartões relatando situações de indisciplina. Os resultados apontam que as minorias ativas apresentam estilos de comportamento de resistência, representações sociais que denunciam às normativas escolares e o status quo. As representações sociais das minorias ativas, alicerçadas na contestação e na resistência, pressupõem barreiras ao avanço do poder majoritário, quando questionam e insistem em mudanças no meio escolar, solicitando maior participação dos estudantes na constituição e aprimoramento das regras.
Incidence of Bacterial Uropathogens and their Antibiotic Susceptibility Pattern Isolated from Urinary Tract Infection in Female Patients
Authors: Bashetti Nivedita R , Vernekar Ritesh , Devaraju Shishir , Hiremath M.B.
Published: June 2024

Urinary tract infection (UTI) is considered as one of the highly prevalent infections worldwide. Regarding its prevalence, UTI is more common in women. The outcome of the research is expected to predict the severity of the urinary tract infection. The study of prevalence and antibiotic susceptibility helps to provide data on the occurrence of uropathogens in different age groups and helps to treat the infection with effective antibiotics to prevent further progression of infection. The study has been carried out to identify and investigate the prevalence of uropathogens and to determine their antibiotic susceptibility potential. Overall, 713 urine samples were collected, MacConkey agar, Blood agar, CLED agar and Luria-Bertani agar were used for isolation of uropathogens by calibrated loop streak method and incubated at 37°C. Antibiotic susceptibility was carried out using the Kirby Disc diffusion method. A total of 665 showed positive bacteriuria. E. coli (37.3%) and K. pneumoniae (32.03%) were the most common uropathogens followed by E. fergusonii (17.9%), P. aeruginosa (8.4%), and A. baumannii (4.4%). The study found that above 70% of antibiotic susceptibility was observed in fluoroquinolones followed by imipenem, while all isolates showed high resistance to ampicillin. The organisms E. coli, E. fergusonii, and P. aeruginosa exhibited the least susceptibility (>50%) for third-generation cephalosporins. P. aeruginosa and A. baumannii showed no susceptibility to nitrofurantoin, whereas other isolates were least susceptible. The study concludes that K. pneumoniae and E. coli were highly prevalent within the study group and that fluoroquinolone and imipenem can be effective for treatment.
Pattern of Mutations in Rifampicin Resistance (rpoB) Gene and Analysis of Rifampicin Indeterminate Result in Tuberculosis Detected by Xpert MTB/RIF Assay in Kalaburagi, India
Authors: Kumar M. Ravish , Doddamani Praveen Kumar , Peter Lavanya S. , Parandekar Prashant , Reddy Shrinivas
Published: June 2024

Tuberculosis (TB) is a serious disease that has been observed since ancient times. In the mid-to late-20th century, the main clinical approach to this disease involved focusing on its diagnosis, prevention, and treatment. However, in the 21st century, the focus has shifted toward the diagnosis and treatment of drug-resistant TB. With the use of the Xpert MTB/RIF assay at the frontlines in India, interpreting indeterminate results to treatment with rifampicin, an antitubercular drug, can be challenging. This is further exacerbated by a lack of knowledge regarding mutation frequency in antitubercular drug-resistant genes in this region. Among antitubercular drugs, rifampicin is the most potent and effective drug for the treatment of tuberculosis; hence, understanding the pattern of rifampicin resistance (rpoB) gene mutations will provide insights into the genetic basis of this resistance, which may help in the prevention and treatment of TB. This retrospective observational study presents sociodemographic details, sample types, Mycobacterium tuberculosis load, types of probe mutations detected, and rifampicin indeterminate results from the Xpert MTB/RIF assay. Of the 314 samples analyzed, 258 showed rifampicin resistance as detected by MTB, with 56 samples of MTB-detected rifampicin indeterminate results. Type E probe mutation (58.9%) was the most common type, while the least frequent mutation was Type C probe (1.5%). No missing probe was observed in approximately 8.9% of samples. Among the 56 rifampicin indeterminate results, the maximum Cycle threshold value did not cross 34.5 in six samples.
Cloning and Production of Protease Enzyme from Aeribacillus pallidus P18 Strain
Authors: Saadati Mahdiyeh , Baltaci Mustafa Ozkan , Adiguzel Ahmet , Erdogan Orhan
Published: June 2024

Proteins are essential for the proper functioning of cells. The techniques of cloning and protein production have facilitated the advancement of various fields and the creation of specific proteins for industrial and therapeutic uses. The bacterium Aeribacillus pallidus, which is able to survive in extreme conditions, is being studied with a view to identifying its robust enzymes. The objective of this study was to clone the protease gene from the A. pallidus P18 strain into the SUMO vector and produce recombinant protein in Escherichia coli BL21 for protein production. The protease enzyme gene from the A. pallidus P18 strain was isolated and amplified by using PCR. The PCR product was transferred into the SUMO expression vector and amplified in One Shot® Mach1TM-T1R bacteria, followed by colony PCR. Plasmid isolation was performed after positive colony selection. Gene integration was confirmed by cross-PCR using the gene forward, and vector reverse primers. For expression, the plasmid was transferred to E. coli BL21 cells. Two cultures were induced with different IPTG concentrations (0.5 mM and 1 mM) to optimize protein production. Bacterial cells were lysed, and SDS-PAGE analysis was conducted. Purification involved cell lysate preparation and purification using a ProbondTM column. SDS-PAGE and Coomassie Brilliant Blue G-250 staining confirmed successful purification. The results of this study indicate that the optimal product for protein production is that derived from a culture induced with 1 mM IPTG. Upon completion of the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) procedure, the weight mass of the produced protein was determined to be 37 kDa, as indicated by the result of the gel stained with Coomassie brilliant blue G-250. This research successfully cloned the protease enzyme gene from the A. pallidus P18 strain using the pET-SUMO vector, performed purification and achieved the targeted result of protein production.
Circuit Breaker System Using IOT Based Smart Load Control
Authors: Sagarika T. , Sai S. Aravind , Nawaz Mohammed Khaja , Vennela B.
Published: June 2024

Abstract: The idea of using Internet Access of Things (IoT) to monitor and regulate circuit breakers is presented in this paper. An essential part of the industrial electrical system is the circuit breaker. It is employed for switching as well as protection. Because of this, a circuit breaker's operational reliability is crucial. Circuit breakers deteriorate with time and with usage. This casts questions on the reliability of the circuit breaker. At certain periods, periodic preventive maintenance is performed to ensure the reliability of the circuit breaker. The current technique of utilizing circuit breakers with hardwired control logic increases the size of a control or metering cabinet and hinders the integration of the web of things. Currently, remote terminals and other proprietary technologies are used to monitor circuit breakers.
Assessing the Status of SDG-9 in Indian States
Authors: Ahmed Kausar , Swain Mrs. Swapna Sarita , Sahoo Ms. Shreeparna
Published: June 2024

Abstract: This research paper evaluates the status of Sustainable Development Goal 9 (SDG 9) across Indian states, focusing on resilient infrastructure, sustainable industrialization, and innovation. It assesses progress using a comprehensive SDG 9 Index based on indicators like infrastructure development, industrial growth, and innovation capacity, derived from credible data sources. The Index employs a weighted scoring system to assign scores to each state, enabling comparative evaluation. Findings reveal significant disparities in SDG 9 performance among states, highlighting areas needing improvement. The study provides valuable insights for policymakers to allocate resources effectively and advance sustainable development in India.
Event Horizon-Shaping Campus Culture Through Advanced Event Management
Authors: Agrawal Ranak , Gupta Priyansh , Prajapati Namit , Bohra Murtaza
Published: June 2024

Abstract: In the dynamic and bustling environment of a college campus, effective event management is crucial to ensure the seamless organization of various activities and to provide students with a centralized platform to access event information. Club managers encounter challenges when it comes to identifying available venues, managing bookings, and promoting their events effectively. On the other hand, students face difficulties in staying updated about upcoming events and registering for those of interest. Our project Event Horizon aims to develop an integrated Event Management System (EMS) that caters to the needs of both club managers and students, thereby enhancing the overall campus experience.
What Are the Main Factors That Influence Purchasing Decisions at Bukalapak?
Authors: Aulia Yasmin Rachma , Wijaya Rahmad , Andharini Sri Nastiti
Published: June 2024

The era of globalization and online transactions has changed many aspects of human life, especially in terms of how people interact, work, shop, and make purchasing decisions. Therefore, this study examines the effect of E-service quality and promotion on purchasing decisions. This data was obtained through an online survey using a Google form for 105 respondents using a purposive sampling technique, di Kota Malang. The data analysis used in this study, namely linear regression analysis, shows that E-service quality has a significant positive effect on purchasing decisions, promotion has a positive and significant effect on purchasing decisions, and promotion is more dominant than e-service quality in influencing purchasing decisions. This finding implies that e-commerce, especially Bukalapak, needs to continue to improve the quality of their electronic services to meet customer expectations. However, sales promotion should remain the main focus of a marketing strategy, as it has a greater influence on driving purchasing decisions.
ХӨХ ХОТЫН БУДДЫН ШАШНЫ СҮМ ХИЙДҮҮДИЙН ХӨГЖЛИЙН ӨНӨӨГИЙН БАЙДАЛ БА НИЙГЭМ СОЁЛЫН АМЬДРАЛД ҮЗҮҮЛЭХ НӨЛӨӨ: ИХ ЗУУ ХИЙДИЙН ЖИШЭЭН ДЭЭР
Authors: Л Түмэнцэцэг
Published: June 2024

ӨМӨЗО-ны засаг захиргааны төв Хөх хот нь олон тооны сүм хийдтэйн учир түүхэнд “Сүм хийдүүдийн хот” хэмээн нэрлэгджээ. Хөх хотын тэрхүү олон сүм хийдийн дотроос хамгийн алдартай нь дөрвөн зуу гаруй жилийн өмнө байгуулагдсан Их Зуу хийд юм. Хэдэн зуун жилийн хөгжил хувьсалыг туулсан Их Зуу хийд өдгөө зөвхөн шашин номын ариун газар бус, харин Хөх хотын соёлын билэгдэл, аялал жуулчлал, амралт зугаалгын төв болж тус хотын нийгэм эдийн засаг, соёлын амьдралд чухал нөлөөтэй газар болжээ. Иймд тус өгүүлэлд Их Зуу хийдээр жишээ болгон Хөх хот дахь Төвөдийн буддын шашны сүм хийдүүдийн хөгжлийн өнөөгийн байдал, үйлдэл нөлөөлөл хийгээд тулгамдсан зарим асуудалд задлан шинжлэлт хийжээ.