bluuebunny/crossref_metadata_2025 huggingface dataset:
Soft skill development in service-learning: towards creative resilience in design practice
Authors: Malinin Laura Healey
Published: October 2017

Service-learning often links academic learning with real-world experiences to encourage experiential knowledge, personal growth and engaged citizenry. It is also considered a high impact practice (HIP) to improve engagement and retention of university students, particularly benefitting underrepresented populations. Less often examined is non-academic skill development necessary for creativity in professional design practice. This paper examines a multi-year service-learning partnership between undergraduate students and youth to design interventions in their middle school building and grounds. The experience incorporated participatory-design and design-build as significant components of an upper division undergraduate elective course in environmental design (architecture, landscape, planning and design studies). Pre- and post-course papers, blog posts and weekly reflections were analysed for themes related to non-academic skill development. Findings suggest positive impacts of service-learning experience on empathy, relationship building, flexibility, systems thinking and professional goals. These are discussed with respect to employability skills towards fostering creative resilience in managing complexities of design practice.
Direction of Achievement Motivation (Adaptation and Transcendence) in Mental Disorders
Authors: Zhiyenbayeva N. , Aknazarov S. , Tapalova O.
Published: October 2017

This article presents an analysis of adaptive and transcendental components of the motivation of achievement in patients with mental disorders. The presented author's model of the motivation of achievement reveals that, in the norm, a person has both components of that model with a temporary predominance or with equal representation of one of them in the human motivational-semantic sphere. With mental pathology, either the extreme manifestation of one of the trends is possible, or an extremely weak representation of both trends. During the course of empirical research which was aimed to identify and analyse the adoptive and transcendental components of the motivation of achievement in psychopathology three additional categories were added to existing key categories of subjects stories analysis on the basis of pictures used in Hekhauzen test. These categories are: “realistic-unrealistic goal setting”; “productive-unproductive instrumental activity aimed at achieving the goal”; “target in the past”.
Desplazamiento forzado y restitución de tierras en Colombia: Una búsqueda de garantías de no repetición
Authors: Cifuentes Chaparro Sneither Efraín
Published: October 2017

El presente artículo afirma que, en el contexto de justicia transicional colombiano, el éxito de la política de restitución de tierras depende, en buena medida, de la capacidad institucional para contrarrestar las causas y consecuencias del desplazamiento forzado interno.

De esta forma, explica que la mayoría de las víctimas desplazadas forzadamente pertenecen a grupos poblacionales históricamente marginados y excluidos en el ejercicio de sus derechos; identifica cuáles han sido los principales factores de despojo y abandono forzado de tierras vinculados al desplazamiento forzado que permiten explicarlo como una práctica de guerra para la acumulación; aborda la política pública de atención a la población desplazada forzadamente como una suma de esfuerzos insuficientes para superar el estados de cosas inconstitucional declarado en 2004; y, a partir de ello, reflexiona sobre las limitaciones de la política de restitución de tierras, luego de cumplirse cinco años de su implementación, para el retorno y/o reubicación de las víctimas, bajo garantías de no repetición de los hechos que dieron lugar a las violaciones masivas y sistemáticas a sus Derechos Humanos.
Transformación de la naturaleza jurídica de la acción de tutela: Análisis en el ámbito del derecho a la salud en Colombia
Authors: Angarita Pinto Alisson , Bejarano Montoya Viviana , Lugo Forero José David
Published: October 2017

La acción de tutela es un mecanismo consagrado en el ordenamiento jurídico colombiano, cuyo objetivo es la protección inmediata de los Derechos Fundamentales, siempre que estos resulten transgredidos o amenazados por la acción o la omisión de cualquier autoridad pública, de un particular encargado de la prestación de un servicio público, o respecto de quienes el solicitante se encuentre en estado de subordinación e indefensión. Este instrumento ha sido concebido con una naturaleza residual y subsidiaria, debido a que solo es procedente cuando no se dispone de otro medio de defensa judicial; salvo que se utilice como un medio transitorio para evitar un perjuicio irremediable. No obstante, este carácter se ha ido transformando con el uso masivo que de esta acción se da, sobre todo en lo que concierne a la defensa del derecho a la salud, ya que, a pesar de la existencia de otros mecanismos destinados para el mismo propósito, se acude a esta de manera preferente y alternativa.
La extensión de jurisprudencia como aporte al procedimiento administrativo colombiano
Authors: Castro López Angie Marcela , Peña Rodríguez Diana Marcela
Published: October 2017

En el presente artículo desarrollamos el mecanismo creado en el nuevo Código de Procedimiento Administrativo y de lo Contencioso Administrativo, denominado extensión de jurisprudencia, donde como objetivo principal estableceremos su naturaleza jurídica la cual nos permitirá identificar aspectos positivos y negativos encontrados desde su creación, procedimiento y aplicación, dentro del sistema judicial colombiano.

Nuestro artículo busca dar respuesta al siguiente interrogante: ¿Cuáles son las fortalezas y deficiencias de la extensión de jurisprudencia?

Para desarrollar el problema de investigación, y dar respuesta a él, hemos acudido al método cualitativo, apoyándonos en jurisprudencia de las altas cortes, memorias de congresos, foros, debates con ocasión a la presentación de la Ley 1437 de 2011, artículos e información en las páginas oficiales de entidades estatales de todo esto realizamos un análisis y comprensión de la nueva figura, llevándonos a encontrar la ardua labor que deberán desempeñar las entidades Administrativas.
Condiciones de las teorías de la pena que permiten la prevención de conductas punibles en marco del posconflicto armado en Colombia
Authors: Zape Ayala Karen , Arboleda Salazar Mario
Published: October 2017

El presente artículo, resultado de una investigación socio jurídica, pretende definir de forma clara las teorías de la pena, como finalidades propias del derecho penal, frente a un tema que convoca toda la atención por parte de la sociedad colombiana, como es el caso del posconflicto armado interno, el cual pone fin a más de 50 años de conflicto entre el Estado Colombiano y la guerrilla de las FARC. Es por esto que la investigación adapta diferentes temas y cuestiona acerca de las finalidades de las funciones de la pena, como medidas preventivas para que no exista la repetición de las conductas punibles, propias de la guerra. Así se desarrolla el escrito, que compone una fase propositiva, una de discusión y las respectivas conclusiones sobre el tema.
The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins
Authors: Mikurova A.V. , Novikova S.E. , Skvortsov V.S. , Alekseychuk N.N. , Rybina A.V. , Miroshnichenko Yu.V.
Published: October 2017

The aim of this study was to evaluate sequence coverage of five model proteins (CYB5A, SMAD4, RAB27B, FECH, and CXXC1) by means of shotgun proteomic data analysis employing different methods of data treatment including database-dependent search engines (MASCOT and X!Tandem) and de novo sequencing software ((PEAKS, Novor, and PepNovo+). In order to achieve maximal results, multiprotease hydrolysis including enzymes trypsin, LYS-C, ASPN and GluC was performed in solution and using the FASP method. High resolution mass spectrometry was carried out with a Q EXACTIVE HF hybrid mass spectrometer in the positive ionization mode; parent ions with the highest intensity and a charge range from +2 to +6 were fragmented in the HCD mode. 27 experiments were carried out (hydrolysis with each of 5 enzymes in solution, 4 for the FASP protocol, three technical repeats). Using parameters limiting false identification of peptides, the search engines and de novo sequencing software gave similar results. The degree of sequence coverage was not at least 40%, and in the best cases it reached 80-90%. The use of de novo sequencing software resulted in identification of the Y12H amino acid substitution in one model protein (CYB5A).
A cryobank as an attribute of omics technologies
Authors: Sazanov A.A. , Erganokov Kh.Kh. , Pfeifer E.
Published: October 2017

Biobanks are systematic and annotated collections of biological samples based on the system of standard operating procedures (SOP) and corresponding to the recommendations of the International Society for Biological and Environmental Repositories (ISBER). Standardization of conditions of obtaining, processing, storage of samples and providing to an end user are crucial in the activities of the biobank. The attributes of biobanks include common principles of labeling and annotation of biological samples using specialized software, an automated monitoring system of storage conditions, and registration of biosamples. Cryobanks are the biobanks maintained at the storage conditions from -196°C to -150°C that provide better cell viability and the highest preservation of biological molecules. Cryobanking is the most essential part of the infrastructure of population and personalized medicine, pharmaceuticals and biopharmacology, conservation of rare and endangered species, as well as biotechnology in general. Next Generation Biobanking, a concept especially designed for omics technologies, involves annotating biological samples on many biomarkers based on Next Generation Sequencing techniques, as well as collecting biological material from the same patient at different time points (for example, at different stages of the disease, before and after the operation, at different periods of therapy) with a detailed annotation of physiological, biochemical and clinical data. Epigenetic studies (DNA methylation, microRNA, etc.), as well as bioinformatic data analysis are of great importance in the activity of Next Generation Biobanking. Such biobanks should function based on the new ethical principles of the post-genomic era.
Pharmacogenetic approaches to predicting the efficiency and safety of amlodipine in patients with arterial hypertension
Authors: Sychev D.A. , Shih N.V. , Kalle E.G. , Ryzhikova K.A. , Morozova T.E.
Published: October 2017

An open, non-comparative, prospective clinical study was conducted to evaluate the antihypertensive efficacy and tolerability of amlodipine, a calcium antagonist, in patients with arterial hypertension (AH) I-II stages, depending on the genotype for the polymorphic marker C3435T of the ABCB1 gene. The study included 100 patients with AH I-II stages, aged from 45 to 58 years. The initial dose of amlodipine was 5 mg, duration of treatment was 12 weeks. General clinical examination methods, office measurement and daily blood pressure monitoring, tolerance evaluation, and genotyping using the ABCB1 polymorphic marker C3435T by the PCR-RFLP method (polymerase chain reaction and restriction fragment length polymorphism) were used. The statistical analysis of results was carried out using the Mann-Whitney U test for quantitative variables, Kruskal-Wallis one-way analysis of variance (ANOVA) for three independent groups of quantitative data. Excellent antihypertensive efficacy with the CC genotype was found in 11.8% patients, with CT – 33.9%, with TT – 43.3%; good – 35.3%, 32.1%, and 33.3% respectively, satisfactory – 52.9%, 34,0% and 23.4% respectively. Six patients with the CT genotype and nine patients with the CC genotype required the increase in the dose to 10 mg. The number of patients with Adverse drug reactions (ADR) were found in 35.3% of patients with the CC genotype, 6.7% with the TT genotype and 11.3% with the CT genotype. The Kruskal-Wallis test revealed significant differences between CC and TT genotypes in the degree of decrease in SBP (p=0.02), antihypertensive efficacy parameter (p=0.02), an increase in dose requirements (p = 0.04) and the incidence of ADR(p=0.05). In AH patients (I-II stage) with the TT genotype of the C3435T gene polymorphism one can expect higher rates of antihypertensive efficacy of amlodipine in combination with a good safety profile and the lowest ADR percentage, while patients with the CC genotype more likely to develop ADR and lower antihypertensive responsiveness.
Changes in laboratory parameters of peripheral blood reflect cell and protein content of the immune system in bone resorption
Authors: Berdugina O.V. , Berdugin K.A.
Published: October 2017

The aim of this study was to investigate dynamic changes in the laboratory parameters of peripheral blood, reflecting cellular and protein composition of the immune system in bone resorption. The study involved 108 patients with degenerative-dystrophic and posttraumatic disorders of the hip joint before and after joint replacement surgery. Half of the cases resulted in bone resorption. Dynamic monitoring was performed up to 7.5 years. It included flow cytometry (Coulter Epics XL, USA) and enzyme immunoassay to determine the amount of immunocompetent cells, immunoglobulin class M, A, G, E, cytokines, acute phase proteins (C-reactive protein, fibrinogen, albumin, ceruloplasmin, haptoglobin), parameters of neutrophil functional activity (lactoferrin cationic protein, myeloperoxidase, superoxide anion production). The results of the study revealed the leading role of haptoglobin, albumin, and IL-1b in bone resorption. The use of multiple regression analysis made it possible to propose criteria for prediction of bone resorption. In particular, the Ig G concentration one month after operation at a value of 13 or less g/l with a probability of 86.8% suggests a high risk of bone tissue destruction in the operated area of the joint (diagnostic sensitivity and diagnostic specificity of 85.7% and 86.9%, respectively). Determination of the IL-1b level also has a good predictive power: its concentration exceeding 191.2 pg/ml six month after surgery with the probability of 87.4% suggests destruction of bone tissue in the operated area of the joint (diagnostic sensitivity and diagnostic specificity of 87.2% and 88.1%, respectively).
The role of polypeptide compounds in mechanism of CNS plasticity in patients with hereditary pathology of peripheral motor neuron
Authors: Sokolova M.G. , Lobzin S.V. , Penniyaynen V.A. , Kipenko A.V. , Lopatina E.V. , Rezvantsev M.V. , Gavrichenko A.V.
Published: October 2017

Synaptic pruning is a physiological mechanism of neuroplasticity, which is regulated through synthesis of growth polypeptides, neurotrophins. The role of neurotrophins in the mechanism of synaptic pruning in patients with hereditary pathology of peripheral motor neuron was studied in a clinical experimental trial. It was found that patients had elevated levels of regulatory growth polypeptides, which led to the axon growth inhibition effect in organotypic tissue cultures. Thus, neurotrophin overexpression can be considered as a factor preventing synaptic pruning and contributing to further process of neurological degeneration in nerve tissue in patients with hereditary pathology of peripheral motor neuron.
Lactose-based glycoconjugates with variable spacers for design of liver-targeted liposomes
Authors: Nosova A.S. , Koloskova O.O. , Shilovskiy I.P. , Sebyakin Yu.L. , Khaitov M.R.
Published: October 2017

Asialoglycoprotein receptors are highly abundant on the hepatocyte surface and have specific binding sites for blood serum glycoproteins. Such discovery resulted in development of liver-targeted drug delivery systems because modification of the liposomal surface by carbohydrate derivatives results in an increase of endocytosis, which facilitates selective uptake of such systems by hepatocytes. In this study we have synthesized novel lactose derivatives containing a palmitic hydrophobic domain. They were used for modification of the liposome surface. Transfection activity of modified liposomes was analyzed on the HepG2 cell line (hepatocytes) and showed an increase in the transfection efficiency as compared to the non-modified liposomes. At the same time transfection activities of modified and non-modified liposomes were similar in the case of a non-hepatocyte cell line (293T). The novel lactose-based glycoconjugates may be a promising tool for developing efficient vectors for delivery of nucleic acids to hepatocytes.
Utilization of insecticide treated nets against malaria among pregnant women in Southern Nigeria
Authors: J. O. Odoko , E. U. Nwose , E. O. Igumbor
Published: October 2017

Malaria remains one of the most important causes of maternal and child morbidity and mortality in sub-Saharan African, despite the availability of effective intervention. Pregnant women are susceptible to symptomatic malaria due to the invasion of the placenta by Plasmodium. There are public health endeavours in promoting use of insecticide treated nets (ITNS), but there is dearth of data on effectiveness of such endeavour. This narrative review looks briefly at the historical background of use of ITNS against malaria, Government policy and program evaluation process on free ITNS for vulnerable groups, relevance of knowledge in use of insecticide treated nets among pregnant mothers, and the role of attitude and practice on effective use of ITNS in prevention of malaria. There is evidence that relatively few people in high-risk regions access and use ITNS. The low utilization of ITNs attributable to perceived cost, inability to adjust to size of the beds, and side-effects heat and ventilation when slept under it.
Assessment of sigma metrics results of serum glucose and lipid profile tested by automated chemistry analyzer in medical city hospitals in Iraq
Authors: Kaftan Ahmed Naseer , Khazal Yaseen Anne , Hasan Zina
Published: October 2017

Background: A major target of quality assurance is the minimization of error rates in order to enhance patient safety, six sigma or sigma metrics were used to assess the analytical quality of automated clinical chemistry, six sigma metrics is used in combination with total allowable error, method imprecision and bias. The goal is to attain the highest possible sigma scale within the acceptable limits of total allowable error. For assessment of sigma metrics results of serum glucose and lipid profile and verification of reference values for these analytes tested by automated chemistry analyzer in Medical City hospitals.Methods: In the present study, internal quality control (EQA) and external quality assessment (EQA) data were analyzed for the period from May to July 2017 using chemistry autoanalyzer (Siemens Dimension RxL Max) at the Teaching Laboratories of the Medical City. Mean, standard deviation, coefficient of variation, bias, total error and sigma metrics were calculated for glucose, cholesterol, triglycerides and HDL.Results: Excellent sigma values (≥6) were elicited for triglycerides (10.9), Satisfactory sigma values (≥3) were elicited for cholesterol (3.4) and HDL (3.4), while glucose performed poorly (2.3) on the sigma scale.Conclusions: Sigma metrics helps to assess analytical methodologies and augment laboratory performance. It acts as a guide for planning quality control strategy. It can be a self-assessment tool regarding the functioning of clinical laboratory. Triglycerides was the best performer when it was gauzed on the sigma scale, with a sigma metrics value of 10.9 and glucose had the least sigma metrics value of 2.5 so there is need for improvement and the method should be controlled with greater attention to ensure quality.
The effect of health education to parent’s behaviours on managing fever in children
Authors: Herman Hermalinda , Nurshal Deswita
Published: October 2017

Background: Fever is one of the common signs that indicate the changes in the body. Generally, parents will do some aggressive actions in dealing with febrile children at home, especially in the use of antipyretic drugs that are not required by the body. The aim of this study is to describe the effect of health education on knowledge, attitude, and action of parents in managing fever of children in Pariaman’s General Hospital. The results of this research can be considered as one of the interventions in the treatment of children in hospital.Methods: The study design is a quasi-experimental with nonequivalent control group approach. Samples are parents who have children with fever sign that were treated in Pariaman’s General Hospital, West Sumatera, Indonesia. Samples were taken by a purposive sampling technique that is in accordance with the criteria set by the researchers. The samples were divided into two groups: the intervention and control groups. Health education about fever was given into intervention groups. In the control groups they received standard care from hospital. The data was collected by questionnaire, that consist of questions about knowledge, attitude an action of parent toward fever in their children. The data statistical was analyzed with independent t test.Results: There are significant differences on knowledge score (p value: 0.009), attitude (p value: 0:03) and action (p value: 0002) of parents between the intervention group and the control group.Conclusions: Therefore, it is expected that health workers and nurses can provide education / health education to parents about fever management in children.
The effects of acute aerobic exercise on choice reaction time in young adults
Authors: Patil Supriya Komalsingh , Patkar Umesh Suresh , Patkar Kshitija Umesh
Published: October 2017

Background:Exercise, especially aerobic exercise thought to have a positive impact on cognitive and brain function which mainly involved in acquisition, processing, storage and executive functions. Executive control processes are important in sport and occupational settings where a person is being asked to make decisions while performing physical work. We have done this study, to determine the effects of acute moderate intensity exercise on cognitive domains and to apply this knowledge in various fields where cognition and executive functions are important. Study and control population each consists of 60 apparently healthy subjects in the age group of 18-30 years.Methods:The material used for study Cosco Upright Exercise Bike and Reaction Time apparatus. Visual Choice Reaction Time, the examiner presented visual stimuli at random to the subject. The subject saw the light displayed on his side and pressed the appropriate corresponding button as quickly as possible and the reading was noted. The same procedure was repeated for auditory choice reaction time for auditory stimuli. After that each subject from study population underwent acute moderate intensity aerobic exercise on for 10 minutes. Starting within 5 minutes after the exercise, subjects were assessed for the same cognitive test as above, for the second time. Control population rested for 10 minutes and then was assessed again for the same cognitive test.Results:There was no significant difference between the pre- values of study population and pre- values of control population. There was no significant difference between the pre- values of control population and post values of control population. Thus, there was no improvement in cognitive functions on account of repetition of tests. There was a significant difference between the post values of study population and post values of control population. There was a significant difference between the pre- values of study population and post values of study population.Conclusions:There was a decrease in reaction time following exercise in the study population, suggests that there was an improvement in the cognitive functions post exercise.
Intra-operative uterine scar condition and fetomaternal outcome in patients of previous lower segment caesarean section (LSCS) with scar tenderness
Authors: Gupta Nidhi , Sinha Renuka
Published: October 2017

Background: During past few years, there is increasing trend in trial of labor in cases of previous lower segment caesarian section (LSCS). It needs vigilant approach in identifying signs and symptoms of giving way of previous scar. This study is to see the intra-operative uterine scar condition and feto-maternal outcome in patients of previous LSCS with scar tenderness.Methods: This is a prospective study done in Safdarjung hospital, New Delhi. It includes 120 patients of previous lower segment caesarian section with scar tenderness operated as emergency cases over a period of one year. It excludes elective repeat LSCS.Results: During this period repeat emergency LSCS was done in 862 cases and scar tenderness was seen in 120 cases (13.92 %). Out of 120 cases enrolled for the study intra-operative scar was intact in 69 cases (57.5%). Scar was thinned out in 27 cases (22.5%). Scar dehiscence was found in 21 cases (17.5%). Rupture occurred in 3 cases (2.5%) out of which 2 were Fresh still births. NICU admission was done in 11 cases (9.17%). 1 neonatal death occurred. No maternal death was recorded. Average hospital stay was 6 days. Blood transfusion was needed in 23 cases (19.2%).Conclusions: Scar tenderness is a very important tool for predicting scar integrity. All cases of previous LSCS should have institutional delivery.
A retrospective analysis of bone tumors and tumor like lesions: a hospital based study of 76 cases
Authors: Deka Manoj Kumar , Talukdar Anuradha
Published: October 2017

Background: Globally Bone tumors constitute 0.5% of the total World Cancer Incidence. In addition to benign and malignant bone tumors there are a number of nonneoplastic lesions that present in a manner similar to neoplastic conditions. Relevant demographic features such as age, sex and skeletal site are important to come to a conclusive diagnosis. The present study aims to show the prevalence and demography of bone tumors and tumor like lesions.Methods: A total of 76 cases of Bone Tumors and Tumor like Lesions were studied. They were reviewed and analyzed for age, gender, site of tumor and histologic types. Classification was done according to WHO histologic Classification of Bone Tumors.Results: There were 49 cases of primary bone tumors and tumor Like lesions with a median age of 22 years and 27 cases of metastatic bone tumors with a median age of 56 years. Males are more commonly affected. Osteosarcomas and Chondrosarcomas are the most common primary malignant Bone Tumors.Conclusions: Metastatic bone tumors constitute the highest number of bone tumors occurring at an older age group. Maximum numbers of bone tumors are found in the age range 11-20 years and all are primary bone tumor and tumor like lesions.
Comparison of intraperitoneal instillation of ropivacaine with normal saline in laparoscopic cholecystectomy
Authors: Bindra Tripat Kaur , Chawla Davinder , Kumar Parmod , Parul .
Published: October 2017

Background: Local anesthetics are now widely used, as they have a good safety profile and are available in long acting preparation. They provide the benefit of analgesia without systemic side effects that may result from use of enterally and parenterally administered drugs.Methods: This prospective randomized double-blind study was conducted on 100 patients with symptomatic gall stones disease undergoing laparoscopic cholecystectomy. Patients were randomized to receive either 0.5% of 3mg/kg of Ropivacaine diluted in 100 ml NS, instillation at intraperitoneal space before creation of pneumoperitoneum (group I) or 100 ml NS instillation at intra peritoneal space before creation of pneumoperitoneum (group II). VAS score for pain abdomen as well as shoulder were recorded postoperatively at various time intervals and compared in both the groups. Total analgesic consumption in 24hrs was also noted and compared.Results: The mean postoperative VAS score for abdomen and shoulder pain was significantly (p values<0.05) lower in group I than in group II till 24 hrs postoperatively. The latency time from end of operation to first analgesic requirement was significantly longer in group I than in group II.Conclusions: Intraperitoneal instillation of Ropivacaine before the creation of pneumoperitoneum significantly decreased the total abdominal pain, shoulder tip pain with lower analgesic consumption. As it is safe and without apparent side effects, we believe that intraperitoneal instillation of local anaesthetic in patients undergoing elective laparoscopic cholecystectomy is an effective modality for postoperative pain management.
Prevalence of metabolic syndrome in patients with premature coronary artery disease proven by coronary angiogram
Authors: Sundaramoorthy Varun , Mambatta Anith Kumar , Chidambaram Yoganathan , Gopalan Rajendiran , Menon Sujaya
Published: October 2017

Background: Metabolic syndrome (MS) is associated with premature coronary artery disease (CAD). The aim of this study was to evaluate the prevalence of MS and its association with severity of CAD proven by coronary angiogram (CAG) in young patients.Methods: We included patients, aged 45 years or less, admitted with acute coronary syndrome (ACS), who had CAD confirmed by coronary angiography. They were divided into two groups according to the presence or absence of MS based on International Diabetes Federation (IDF) criteria. CAD was classified into single, double and triple vessel disease (TVD). The prevalence of MS and its individual parameters was calculated.Results: Among 90 young patients who presented with ACS, MS was present in 67 patients (74.44%). Among those with MS, the prevalence of each individual criterion was statistically significant in MS group (P <0.05). Prevalence of pre-existing hypertension and diabetes was significantly higher in MS group (p <0.01). Smoking, alcohol consumption and family history of CAD were not statistically significant in patients with and without MS. Fifteen out of 90 patients (14 in MS group) who presented with ACS had TVD in CAG, but this was not statistically significant (p 0.06).Conclusions: This study confirms a very high prevalence of MS in young Indian patients with premature CAD. MS was more prevalent than the conventional risk factor smoking in young CAD patients. We could not find significant difference in severity of CAD based on CAG between MS and non-MS group.
Evaluation of student assessment practices in a medical college
Authors: Elfaki Omer A. , Alamri Abdulaziz A.
Published: October 2017

Background: The importance of students’ assessment and its role in driving students learning are well recognized. Guidelines for good assessment practice have been developed. The GMC issued important recommendations related to assessment of students’ performance to be followed by medical schools in UK. The Liaison Committee on Medical Education (LCME) developed standards emphasizing the importance of documenting students’ performance. The utility concept of an assessment tool had been proposed by Van der Vleuten stating a number of weighted criteria. Assessment of clinical competence was proposed to be well covered by the model of Miller. No single method of assessment can be recommended to be appropriate for all assessment purposes and all domains of competence. Therefore, multiple methods of assessment are required.Methods: There are 35 courses included in the MBBS program in the college of medicine, KKU. these are taught over five years in addition to a preparatory year and the internship year. the curriculum can still be described as discipline based. a survey was planned to study the current assessment situation. this is a cross-sectional descriptive study. the data collection methods used were survey and study of the documents of the courses. an online questionnaire was developed. the responses were analyzed using descriptive statistics to determine frequencies, averages and percentages. the study was conducted during the period January-May 2014.Results: Twenty course coordinators responded to the survey (57%). Eleven of the courses covered were basic and nine were clinical. Multiple tests as well as multiple methods of continuous assessment were used in the courses studied. Some of the methods used for summative assessment are no longer recommended in current assessment practices in medical education. Real OSCE was used only in one clinical course. Standard setting methods were not used and a fixed pass mark was used instead.Conclusions: Important shortcomings in student assessment system in many of the courses studied were identified. Less educationally desirable assessment methods and practices are still used in some courses such as unattended single long case examination. More attention should be given to technical aspects of assessment.
Surgical approach of bentall procedure in a patient of pectus excavatum
Authors: Pramanik Subrata , Padhy Ajit , Raja Nayem , Satyarthy Subodh
Published: October 2017

A middle-aged man diagnosed case of Marfan syndrome associated with pectus excavatum presented with chest pain and dyspnea. Chest X-ray, transthoracic echocardiography and Computed tomography (CT) of heart and aorta revealed severe Aortic regurgitation with dilated aortic root, sinotubular junction and ascending aorta with normal size arch and descending aorta. Patient was taken for surgery. Pectus excavatum creates difficulties for heart exposure and cannulation for cardiopulmonary bypass. We planned for femoro-femoral bypass to carry out ahesiolysis and Bentall procedure without much difficulties. Postoperative stay of the patient was uneventful and followed up in regular interval.
Late adolescent primary nocturnal enuresis: a case report
Authors: Selvaraj Periyar Rani , Thirumalai Ranganathan
Published: October 2017

Primary nocturnal enuresis is a rare condition. Literature review revealed that 1% of boys still bed wet at 17 years of age. There is a paucity of literature on the incidence and prevalence of bed wetting in patients above 17 years of age. We therefore present a case of 18-year-old boy having bed wetting since childhood.
Brown Jaw Tumors: challenges and outcomes
Authors: Abdelrahman Tarek Elsayed Ftohy
Published: October 2017

Background: Brown tumors are very rare giant cell lesions that arise as a result of hyperparathyroidism, brown tumors rarely affect the mandible and maxilla and its diagnosis and treatment is very challenging and needs a high index of suspicion.Methods: Retrospective chart review of nine cases diagnosed as brown jaw tumors treated in maxillofacial, head and neck surgery unit, department of surgery, Sohag University hospital.Results: They were 9 patients, 3 males and 6 females with a mean age of 43.3 years. Lesions were located in the mandible (4 cases), maxilla (3 cases), both mandible and maxilla (2 cases). The main presentation was a mass lesion. Clinical examination and serum parathormone, serum calcium, serum phosphorus, neck ultrasonography, parathyroid scan was used for diagnosis. Cases did excision with parathyroidectomy. There was no recurrence during a mean follow up period of 9.3 months. All patients had satisfactory results.Conclusions: All cases with osteolytic lesions in mandible or maxilla the possibility of brown tumors should be kept in mind especially if there is any manifestation of hyperparathyroidism. This report will aid in the recognition and treatment of the jaw brown tumors.
Pilonidal sinus- limberg versus karidakis flap our experience at SIMS, Shivamogga
Authors: A. Madhusudhan , Swamy Madhan D. P. , Arif Mohhamad
Published: October 2017

Background: The etiology and pathogenesis of sacro-coccygeal pilonidal sinus are not clear. The pathogenesis of the disease is hypothesized to be related to the accumulation of weak and lifeless hair in the intergluteal region, which over time gives rise to foreign body reaction, causing abscess and sinus formation. A deep natal cleft with one of favourable factors enhance sacro-coccygeal pilonidal sinus, e.g., sweating, maceration, bacterial contamination and penetration of hairs. Obesity, trauma, local irritation and a sedentary lifestyle are usually associated with PS. Although pilonidal sinus can be treated using various conservative and surgical methods, recurrence rate remains high. Complete surgical removal of the pilonidal sinus or sinuses and appropriate reconstruction can lead to successful recovery. However, collection of the lifeless hair depends on the anatomy of the intergluteal area, and accompanying risk factors can lead to subsequent recurrence.Methods: The objective of this study is to compare the immediate post-operative and long-term results of Limberg flap and Karydakis flap, which are being widely used now to treat pilonidal sinus disease. It was a retrospective observational study where the patients (total number of patients-30) who underwent both the procedures were compared, Limberg flap (LF; n = 13) and Karydakis flap (KF; n = 17).Results: Present study found out that short and long-term results of the LF and KF procedures are similar. In present study we also noted that all patients with pilonidal sinus disease were men, and most of them had jobs which involved sitting for long durations. Poor hygiene and hirsutism however was not noted in most of the patients, and was not objectively assessed.Conclusions: Both the techniques can be used safely and effectively in sacro coccygeal pilonidal sinus disease.
A comparative evaluation of Transurethral Electro-Vaporisation of Prostate (TUEVP) versus Transurethral Resection of Prostate (TURP) for Benign Prostatic Hyperplasia (BPH)
Authors: Saini Rijul , Saxena Kartik , Makkar Gourav S. , Shivam Shekhar , Desai Sandip , Singh Shivam , Gupta Nishi
Published: October 2017

Background: Transurethral Resection of Prostate (TURP) has been gold standard of surgical treatment of BPH but nonetheless it is associated with many complications. Transurethral Electro-Vaporisation of Prostate (TUEVP) is a new promising modality which has similar results and better side effect profile.Methods: A prospective, randomised, comparative study was conducted on seventy patients with symptomatic BPH in the Surgery department of Sanjay Gandhi Memorial Hospital, Delhi over two years starting from December 2014. These patients were randomly assigned to two groups- A and B using online random number generator. Patients of group A underwent TUEVP and those of group B underwent TURP. Overall patient satisfaction, patient safety, procedural efficacy and operative ease of the surgeon were compared.Results: Mean operative time (42.1 min in TUEVP and 38.4 min in TURP) and complication rates (14.3% in TUEVP and 11.4% in TURP) were comparable in both groups. Intra-operative bleeding was significantly less (2.9% in TUEVP; 22.9% in TURP) and visual clarity of operative field was significantly better in TUEVP (persistently clear in 97.1% in TUEVP; 77.1% in TURP). The mean catheterisation time (1.14 days in TUEVP and 2.51 days in TURP) and hospitalisation time (2.14 days in TUEVP and 3.1 days in TURP) were significantly shorter in TUEVP.Conclusions: TUEVP is comparable to TURP in terms of patient satisfaction, safety, operative time and procedural efficacy. TUEVP has shorter duration of catheterisation and hospitalisation and is better than TURP in terms of intra-operative bleeding and operative ease of the surgeon.
Association between serum linezolid concentration and haematological toxic effects: a longitudinal study
Authors: Hombal Prashant R. , Gudadappanavar Anupama M. , Javali S. B.
Published: October 2017

Background: Linezolid is a commonly used antibiotic and reported various drug related adverse effects mainly haematological toxicity like thrombocytopenia, leukopenia and anaemia. But a significant association between linezolid plasma concentration and drug related adverse effects are not documented yet. This longitudinal observational study aims to study the incidence of drug related haematological toxicities and its association with serum Linezolid concentration and also evaluate the clinical outcome.Methods: After obtaining informed consent, each patient (18-50years) was given linezolid (600mg/12hourly), and evaluated for haematological (haemoglobin, platelets, WBCs), renal (as serum creatinine), and hepatic (as serum transaminases status), together with an assessment of drug C min values. These evaluations were repeated once a week or in concomitance with the development of an adverse event up to the end of linezolid therapy. The parametric dependent ‘t’ test was applied (p<0.05) and normality of data were performed by Kolmogorov Smirnov test, follows normal distribution.Results: There was significant reduction in platelet count and haemoglobin value seen from baseline till end of treatment (p<0.001) and there was 13% reduction in WBC count in all patients on day 14 when compared to baseline (p<0.001) indicating haematological toxicity according to WHO toxicity grading scale. All the patients (n=8; 26.6%) who developed drug related haematological toxicity also showed comparable increase in plasma linezolid concentration (C min) >10mg/L at the end of 14days.Conclusions: The capability to monitor plasma linezolid concentration (C min; trough value) once a week may lead to a significant improvement in clinical use of the drug both in terms of efficacy and tolerability as the study observed that there is association between linezolid concentration and risk of developing drug related haematological toxicity.
Leydig cell tumor of testis- a rare case report
Authors: Arora Sheetal , Pujani Mukta , Rana Deepshikha , Chaudhaury Narendra
Published: October 2017

Leydig cell tumors(LCTs) of testis are rare testicular tumors of male gonadal interstitium. Although rare, they are most common sex cord stromal tumors and comprise 1-3 % of all testicular neoplasms. They usually occur in fourth to sixth decade. In young patients, they are mostly benign and in adults it can be malignant in about 10 % cases. The incidence of Leydig cell tumors is gradually increasing every year which might be attributed to increased use of radiological techniques and subsequent early detection of tumors that have not been found in historical series. Here we report a case of benign Leydig cell tumor testis in a 45-year-old male who presented with left sided testicular mass. The patient subsequently underwent high inguinal orchidectomy. Histopathological examination showed benign pure Leydig cell tumor. Serological investigations revealed normal testosterone levels, DHEA and androstenedione levels. Immunohistochemical staining for inhibin showed fine granular cytoplasmic positivity and diffuse positive staining for Melan-A which further confirmed the diagnosis. The endocrine profile and imaging investigations of such patients might be normal and patients can be totally asymptomatic. However periodic follow up of endocrine profile and imaging must be done as many cases have been reported which had deranged endocrine levels and appearance of atypical symptoms even after years of unilateral orchidectomy. Our case also presents with normal hormonal levels, henceforth for a better prognosis we must identify benign LCTs and do long term follow up.
A influência da apresentação do preço (em formato de áudio) sobre as percepções dos clientes
Authors: Rodrigues Hugo Leonardo , Mainardes Emerson Wagner
Published: October 2017

Este estudo buscou por meio de experimentos verificar os impactos decorrentes da utilização do dígito “9” no formato de preços (na modalidade de áudio) sobre a percepção das pessoas. A pesquisa foi desenvolvida em 3 experimentos. Em cada um dos experimentos, os respondentes foram divididos em dois grupos, cada um com uma oferta em áudio e com formato de preço diferente (com e sem o dígito nove na oferta). As amostras eram semelhantes entre si. Como instrumento de análise foi utilizado o teste-t student. De um modo geral, os resultados do teste t evidenciaram que a utilização do dígito “9” no formato do preço pode impactar a percepção dos clientes quanto à avaliação do preço, à avaliação da oferta, à intenção de compra, à avaliação da propaganda, à indicação da loja, à avaliação das relações de custo versus benefício e à avaliação do formato da propaganda.
Currículo mundial e ensino de contabilidade: estudo comparativo da matriz curricular de ciências contábeis em instituições de ensino superior brasileiras e francesas
Authors: Kouloukoui Daniel , Ribeiro da Silva Antonio Carlos , Bezerra Gabriel José Ronaldo , Gonzaga Andrade Jacilene Oliveira
Published: October 2017

Este trabalho teve como objetivo analisar e comparar as matrizes curriculares dos cursos de Ciências Contábeis das instituições de ensino superior (IES) da França e do Brasil em relação ao Currículo Mundial (CM), proposto pelo ISAR, grupo de trabalho da Conferência das Nações Unidas sobre Comércio e Desenvolvimento (UNCTAD). Para alcançá-lo, realizou-se uma pesquisa exploratória baseada na análise documental de informações dos cursos de graduação em Ciências Contábeis de 10 universidades francesas e 10 brasileiras. Após a organização e classificação dos dados, realizou-se um estudo descritivo para verificar as similaridades entre os currículos dos cursos e o CM. Dentre outros achados, os resultados revelaram que 72% das IES francesas e 61% das brasileiras possuem matrizes curriculares correlatas ao CM. Concluiu-se que, de forma geral, as matrizes curriculares das universidades dos dois países estão próximas do CM.
Os parques tecnológicos como agentes imobiliários na América Latina
Authors: Torres Stephanie , Alves Silvana , Vidal Francisco
Published: October 2017

Parques tecnológicos são espaços físicos que articulam as atividades entre o governo, a academia e empresas para promoverem a disseminação de conhecimento e a competitividade regional e nacional, por meio da oferta de novos processos, produtos e serviços. Embora muito se tenha discutido sobre eles, ainda são poucos os estudos que se ocupam de sua análise no contexto da América Latina. Perante esse cenário, realizou-se um estudo de casos múltiplos para avaliar e comparar qualitativamente oito parques naquela região geográfica. Com base no conceito de habitat de inovação, foram identificados pontos-chave condicionantes que estão incorporados à gestão imobiliária de tais empreendimentos. Evidenciou-se, ainda, os macro- e microambientes que influenciam a sustentabilidade dos parques, o que permitiu traçar recomendações para viabilizar a cooperação e a integração dos pontos-chave na efetiva geração e transferência de tecnologias dos parques latino-americanos.
Análise da criação de valor em uma operação de leveraged buyout (LBO) No Brasil
Authors: Mitre Filho Marcelo , Albuquerque Andrei Aparecido de , Paixão Michel Augusto Santana da
Published: October 2017

Fazendo uso de um modelo de negócio baseado na aquisição de empresas com potencial de crescimento, os private equities desenvolveram as leveraged buyouts (LBOs). Para a aquisição da empresa-alvo, utiliza-se a dívida como pagamento de parte significativa do valor da aquisição. Um dos principais objetivos das LBOs é possibilitar que entidades financeiras realizem um volume considerável de aquisições sem comprometer substancialmente o patrimônio e o capital próprio, mitigando o risco do investimento e maximizando o retorno. Este artigo visa analisar a criação de valor em uma operação de LBO no mercado brasileiro, através do uso do Economic Value Added (EVA®). O método de pesquisa empregado foi o ex post facto, baseado em uma pesquisa qualitativa. O resultado encontrado indica evidências inconclusivas quanto a destruição do valor em uma operação de LBO nacional, considerando outros possíveis elementos responsáveis pelo indicador EVA® negativo.