bluuebunny/crossref_metadata_2025 huggingface dataset:
The Nurse and Ambulatory Care
Authors:   Independent Researcher, Europe, S Franjic
Published: March 2023

When considering the concepts of nursing and the scope of work covered by the nursing profession, many mainly think of the hospital center and the health care of patients in the hospital bed. However, nurses, as the only and responsible providers of health care, can also perform their work in health centers, community health services, emergency medical services or in private practice. Nursing is an integral part of the entire healthcare business. Therefore, the organization of work in nursing must be flexible, dynamic and stimulating for the development of modern trends in health care. The common purpose of the health team is to improve, preserve and restore the health of the individual.
Tax loss carryforwards: valuation of deferred tax assets
Authors: Aksent’ev A. A.
Published: March 2023

In the article, a comparative analysis of modern approaches to the assessment of deferred tax assets recognized for tax losses is carried out. The ambiguity of tax losses as an object of accounting observation is substantiated. Positive and negative effects of tax losses that do not allow to objectively qualify tax benefits as assets in accordance with conceptual criteria for their recognition are characterised. Prospective and retrospective factors for assessing the future recovery of deferred tax assets are presented. An example of accounting entries regarding recognition and recovery of tax losses using a valuation account is provided. The timing of prospective analysis is justified. Conservative and affirmative approaches to the assessment of tax losses in the financial accounting system are described. Based on the findings of the study, conclusions are given, and lines of future research are suggested.
Influence of industrial production of Russian regions on foreign trade indicators
Authors: Krasnykh S. S.
Published: March 2023

The study is devoted to the assessment of the impact that industrial production of Russian regions has on the country’s foreign trade performance. The chosen topic is relevant due to the fact that today’s sanctions policy of various Western countries is restricting exports and imports of many types of products, which can serve as a threat to the economic security of the Russian Federation. The author of the article determines the impact of mining, manufacturing, and the provision of electricity, gas and steam on foreign trade performance by using regression analysis of panel data and the Granger causality test. It is found that an increase in mining production contributes to regional export growth but has a negative effect on imports of goods and services. The Granger causality test has not revealed the impact of manufacturing and the provision of electricity, gas and steam on foreign trade indicators.
On the concept of university competitiveness management
Authors: Pirogova E. V.
Published: March 2023

Operating under market economy conditions, higher education institutions should develop a set of strategic measures to ensure their competitiveness. The system of views on solving the problems of achieving and keeping competitive advantage is mainly represented by the concept of managing the competitiveness of higher education institutions. The article is devoted to identifying the features and clarifying the content of this concept. It is determined that its content is a set of goals, principles, functions, methods, and tools that ensure the competitiveness of a university in the educational services market. The aforementioned content components are analysed in detail. Methods of managing university competitiveness are substantiated and classified based on the type of controlling influence. Tools for managing competitiveness are described, including in terms of their impact on end users of scientific and educational products (services).
Features of modern organization management when implementing a digital transformation strategy
Authors: Zheregelya A. V.
Published: March 2023

The article examines the factors that determine the features of organization management in the process of implementing the digital transformation strategy in modern conditions, and gives their assessment. The results of a survey of employees on the issue of readiness to work in a digital environment when business processes change are presented. The conditions for the development of digital transformation of a modern organization and the work of personnel, as well as positive and negative factors determining the proliferation of this process are analyzed. The aspect of the institutional field of the new management paradigm, which determines the resilience of new formats of professional activity in the emerging digital reality, is touched upon. It is concluded that the process of digital transformation as a new management paradigm, which, unlike traditional approaches, involves a fundamental restructuring of the existing structure, business processes, organizational and managerial mechanism of interaction with all stakeholders and provides transformation of the organization by revising the culture, strategy, models, operations, products, marketing, goals, including employee management. In turn, this will require, on the one hand, the transformation of the technologization process of management, intensifying interaction with personnel and creating effective communication channels, on the other hand, the cascadability of management processes that form other methods of this interaction, having a positive impact on both the effectiveness of managerial, economic and organizational processes, and on a quality solution of specific tasks.
Educational services export: competition in new geopolitical conditions
Authors: Bykovskaya E. N. , Rybina M. N.
Published: March 2023

Geopolitical tensions are on the rise. The competitive struggle in the field of educational services export does not stand aside either. In a fierce confrontation, a rich arsenal of modern technologies is used. Using the information onslaught, the ideology, the mentality of the younger generation, its worldview positions become the goal of this struggle. Russia has always been a competitive country in the export of educational services. However, in today’s conditions of fierce competition, it is necessary to defend one’s positions, find advantages in the Russian educational system, relying both on accumulated experience and using innovative approaches. In order to be competitive in the modern world community, during the transition to a new technological order, it is necessary to offer innovative products in the field of education, expand the range of the subjects of the educational environment on various regional platforms.
Mapping the chemical space of active-site targeted covalent ligands for protein tyrosine phosphatases
Authors: Hong Suk ho , Xi Sarah Y , Johns Andrew C , Tang Lauren C , Li Allyson , Hum Madeleine N , Chartier Cassandra A , Jovanovic Marko , Shah Neel H
Published: March 2023

Protein tyrosine phosphatases (PTPs) are an important class of enzymes that modulate essential cellular processes through protein dephosphorylation and are dysregulated in various disease states. There is demand for new compounds that target the active sites of these enzymes, for use as chemical tools to dissect their biological roles or as leads for the development of new therapeutics. In this study, we explore an array of electrophiles and fragment scaffolds to investigate the required chemical parameters for covalent inhibition of tyrosine phosphatases. Our analysis juxtaposes the intrinsic electrophilicity of these compounds with their potency against several classical PTPs, revealing chemotypes that inhibit tyrosine phosphatases while minimizing excessive, potentially non-specific reactivity. We also assess sequence divergence at key residues in PTPs to explain their differential susceptibility to covalent inhibition. We anticipate that our study will inspire new strategies to develop covalent probes and inhibitors for tyrosine phosphatases.
Broadening the scope of binding free energy calculations using a Separated Topologies approach
Authors: Baumann Hannah , Dybeck Eric , McClendon Christopher Lee , Pickard Frank , Gapsys Vytautas , Pérez-Benito Laura , Hahn David , Tresadern Gary , Mathiowetz Alan , Mobley David
Published: March 2023

Binding free energy calculations predict the potency of compounds to protein binding sites in a physically rigorous manner and see broad application in prioritizing the synthesis of novel drug candidates. Relative binding free energy calculations (RBFE) have emerged as an industry standard approach to achieve highly accurate rank-order predictions of the potency of related compounds; however, this approach requires that the ligands share a common scaffold and a common binding mode, restricting the methods' domain of applicability. This is a critical limitation, since complex modifications to the ligands, especially core hopping, are very common in drug design. Absolute Binding Free Energy calculations (ABFE) are an alternate method, which can be used for ligands that are not congeneric. However, ABFE suffer from a known problem of long convergence times, due to the need to sample additional degrees of freedom within each system, such as sampling rearrangements necessary to open and close the binding site. Here, we report on an alternative method for RBFE, called Separated Topologies (SepTop), which overcomes the issues in both of the aforementioned methods, by enabling large scaffold changes between ligands with a convergence time comparable to traditional RBFE. Instead of only mutating atoms that vary between two ligands, this approach performs two absolute free energy calculations at the same time in opposite directions, one for each ligand. Defining the two ligands independently allows the comparison of binding of diverse ligands without the artificial constraints of identical poses or a suitable atom-atom mapping. This approach also avoids the need to sample the unbound state of the protein, making it more efficient than absolute binding free energy calculations. Here, we introduce an implementation of SepTop. We developed a general and efficient protocol for running SepTop, and we demonstrated the method on four diverse, pharmaceutically relevant systems. Here we report the performance of the method, as well as our practical insights into strengths, weaknesses, and challenges of applying this method in an industrial drug design setting. We find that the accuracy of the approach is sufficiently high to rank order ligands with an accuracy comparable to traditional RBFE calculations, while maintaining the additional flexibility of SepTop.
Synthetic glucuronoxylomannans enable molecular insights into antibody structure-function and fungal capsule architecture
Authors: Crawford Conor J. , Guazzelli Lorenzo , McConnell Scott A. , McCabe Orla , d'Errico Clotilde , Greengo Seth , Wear Maggie P. , Jedlicka Anne J. , Casadevall Arturo , Oscarson Stefan
Published: March 2023

Antibodies play critical roles in protection against infectious diseases and can be passively administered to protect patients. In the case of antibodies against glucuronoxylomannan (GXM), the major constituent of the Cryptococcus neoformans capsule, this results in protective, non-protective and disease enhancing outcomes. We sought to improve our basic understanding of these functionally different antibodies. Here we report a library of twenty-six synthetic GXM oligosaccharides, consisting of M2 (serotype A), M4 (serotype C), and M1 motifs (serotype D). These GXM glycans range in size from 1-mers to an 18-mer and were used to construct a microarray containing both O-acetylated and non-acetylated glycans. This allowed mapping of the binding preferences of sixteen functionally different monoclonal antibodies to the Cryptococcus capsule. This data is complemented by sequence comparison analysis of fragment antigen-binding (Fab) region which revealed how small changes (<13) in Fab sequence can affect antibody antigen specificity and function. While, changes in the constant region (isotype switching) altered glycan specificity. Furthermore, by combining immunofluorescence imaging of fungal cells and knowledge of antibody binding specificities, we gained direct evidence for the molecular complexity of cryptococcal capsules. Our results highlight the complex relationship between antibody epitope, affinity and isotype class, all of which act synergistically to contribute to a protective or non-protective immune response, meaning that binding specificity alone is not sufficient to predict an antibodys function. These results are relevant to the design of vaccines against Cryptococcosis.
Digital pipette: Open hardware for liquid transfer in self-driving laboratories
Authors: Yoshikawa Naruki , Darvish Kourosh , Garg Animesh , Aspuru-Guzik Alan
Published: March 2023

Self-driving laboratories promise to democratize automated chemical laboratories. Accurate liquid handling is an essential operation in the context of chemical labs, and consequently a self-driving laboratory will require a robotic liquid handling and transfer. Although many pipettes are available for human scientists, robots cannot manipulate these pipettes due to the limitations of current robot gripper morphology. We propose an intuitive yet elegant design for a 3D-printed digital pipette designed for robots to carry out chemical experiments. Performance-evaluation experiments were carried out liquid transfer tasks. Our results show that robots with digital pipette could transfer liquids within 0.5% error. This error is comparable to the baseline set by commercially available human-handled pipettes.
Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
Authors: Saikumar Lakshmi Priya , Oduor Cliff I , Forconi Catherine S , M’Bana Viriato , Bly Courtney , Gerstein Rachel M , Otieno Juliana A , Ong’echa John M , Münz Christian , Luftig Micah A , Brehm Michael A , Bailey Jeffrey A , Moormann Ann M
Published: March 2023

Endemic Burkitt lymphoma (BL) is a childhood cancer in sub-Saharan Africa characterized by Epstein–Barr virus and malaria-associated aberrant B-cell activation andMYCchromosomal translocation. Survival rates hover at 50% after conventional chemotherapies; therefore, clinically relevant models are necessary to test additional therapies. Hence, we established five patient-derived BL tumor cell lines and corresponding NSG-BL avatar mouse models. Transcriptomics confirmed that our BL lines maintained fidelity from patient tumors to NSG-BL tumors. However, we found significant variation in tumor growth and survival among NSG-BL avatars and in Epstein–Barr virus protein expression patterns. We tested rituximab responsiveness and found one NSG-BL model exhibiting direct sensitivity, characterized by apoptotic gene expression counterbalanced by unfolded protein response and mTOR pro-survival pathways. In rituximab-unresponsive tumors, we observed an IFN-α signature confirmed by the expression of IRF7 and ISG15. Our results demonstrate significant inter-patient tumor variation and heterogeneity, and that contemporary patient-derived BL cell lines and NSG-BL avatars are feasible tools to guide new therapeutic strategies and improve outcomes for these children.
Evolution of Growth Model and Cultivation of Competitive Advantages Under the Ambidextrous Innovation Strategy: In the Case of China’s High-Tech Enterprises
Authors: Zhang Xinyuan , Quah Chee Heong , Bin Mohd Nor Mohammad Nazri
Published: March 2023

This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy. After a brief introduction of the connotation of ambidextrous innovation strategy, the evolution of growth model of high-tech enterprises under the conventional strategy and the ambidextrous innovation strategy is analyzed. Furthermore, a discussion is made on how to cultivate enterprises’ competitive advantages under the ambidextrous innovation strategy, thereby enabling enterprises to stand out from competitors under this new strategic model and truly achieve the goal of sustainable development.
Analysis on enhanced turbulent heat transfer and flow characteristic in a twisted and dimpled oval tube
Authors: DAĞDEVİR Toygun
Published: March 2023

This work reveals the heat transfer and flow characteristic in a twisted and oval tube under turbulent flow and constant heat flux conditions. Numerical analyses were carried out on several twisted and oval tube configurations. In order to clearly reveal the effect of dimples in the swirl flow, the twisted oval tubes with and without dimples are considered. In order to enhance the convective heat transfer, the dimples were placed in the narrowing region of the twisted tube where the heat transfer was inefficient. The results indicate that the dimples on the twisted tube significantly increase the heat transfer, although they cause to slightly increase pressure drop penalty. While the decrease in the pitch length induced to enhance the heat transfer, it significantly and negatively affected the hydraulic performance of the tube. Furthermore, while the dimples on the twisted oval tube induce the average Nusselt number to increase by 14.8%, they cause to the friction factor increase by 18.0%. The best configuration that is the case of dimpled twisted oval tube having pitch length of 200 mm at Reynolds number of 10,000, yields thermo-hydraulic performance criteria of 1.428.
Ethical soundness of health technology assessment reports in Islamic Republic of Iran
Authors: Yazdi-Feyzabadi Vahid , Bashzar Salman
Published: March 2023

Background: Health technology assessment (HTA) is a conventional method for evaluating reasonable use of health technologies in many countries. Aims: To investigate the ethical soundness of HTA studies in Islamic Republic of Iran. Methods: All HTA reports published by the HTA office until 2020 were reviewed using the HTA Core Model and the Q-SEA questionnaires. Results: We evaluated 91 reports for ethical soundness. The research question, literature search and inclusion/exclusion criteria were included in 91.2%, 83.5% and 82.4% of the HTA reports, respectively. Only 13.2% of the reports explicitly stated the objective of the analysis and 6.6% stated the ethics framework. Only 2.2%, 4.4%, 9.9%, 9.9%, 14.3%, and 2.2%, respectively, of the reports, complied with the completeness, bias, policy implications, other implications, conceptual clarification, and conflicting values. Conclusions: HTA reports in the Islamic Republic of Iran require coordinated and integrated framework acceptable to all stakeholders to ensure their compliance with sound ethical requirements.
Justice as the Ultimate Goal of Criminal Law: General Theoretical and Methodological Contexts
Authors:   Kazan Federal University, Kazan, 420008 Russia, Ashrafzyanov I.R.
Published: March 2023

This article aims to identify the key theoretical and methodological challenges associated with justice in criminal law and to find possible ways of overcoming them. Using the main principles of social philosophy and theory of law, the relationship between justice and law and the content of justice in criminal law were considered. It was demonstrated that justice must be pursued as an ultimate social goal of positive law, including criminal law: justice is a qualitative state of social relations when every person can fulfill their potential and is paid according to the public benefit from their work, and senior positions are held depending on the level of expertise, experiences, and meritorious service. Criminal law defines what activities are criminal, as well as specifies possible penalties to correct the convicted person’s behavior and prevent future crimes. These challenges should be the subject of in-depth analysis taking into account the achievements of Soviet criminal law and corrective labor legislation. The results obtained are of practical importance because they can be useful in building a system of criminal law measures to administer justice.
Trends in the Development of Ideas about Just Laws in Russian Legal Doctrines of the 18th Century
Authors:   Kazan Federal University, Kazan, 420008 Russia, Gilmullin A.R.
Published: March 2023

This article reveals the conditions under which the philosophy of law developed in Russia, with the focus on its unique features and the role played by foreign thinkers in this process. The doctrinal views expressed by several prominent Russian scholars of the 18th century (V.N. Tatishchev, M.M. Shcherbatov, Ya.P. Kozelsky, and A.N. Radishchev) on the key ideas, principles, and attributes of law in general and just law in particular were considered in order to show how they are connected, as well as to better understand the background of modern legal science. The following major ideas were discussed: V.N. Tatishchev’s understanding of natural law as a basis of all positive laws; M.M. Scherbatov’s differentiation between divine and civil laws; Ya.P. Kozelsky’s doctrine of “righteous” and “unrighteous” law; and A.N. Radishchev’s opinion that positive laws should not contradict natural laws. Based on the results obtained, it was concluded that the doctrinal views of the 18th century on just laws that followed the tradition of natural law and proclaimed that any just law must comply with the needs of a human, resist and limit the arbitrary actions of authorities, be a driving force for achieving the common good, etc. were a result of the well-thought choice of the most essential freedoms and responsibilities. Therefore, they may well be regarded as a great achievement of Russian legal science in creating the legal foundations for the sustainable development of humans.
Exploring Managers' Skills Affecting Dynamic-Innovative Capabilities and Performance in New Normal Era
Authors: Rakangthong Neeranat K. , Hareebin Yuttachai , Dowpiset Kitikorn , Jutidharabongse Jaturon , Aujirapongpan Somnuk
Published: March 2023

The human resources department, as a dynamic mechanism in the hotel business, is a supporter and a manager who manages the corporation to grow by planning, supervising, and assuring the expected performance leads to desirable outcomes. The situation of spread of the COVID-19 virus has resulted in businesses and labor departments having to adapt to survive by upgrading existing knowledge and adding new skills. Therefore, this research aims to describe components and models of necessary skills development for performance affecting dynamic capabilities and performance in a new normal era for human resources managers of five-star hotels in Phuket Province, which are crucial components in an increased corporation’s sustainability and performance in terms of personnel efficiency, assets, funds, and information. This research is quantitative, and research data was collected from a total of 384 human resource managers of five-star hotels. There was a mutual discussion of factor analysis and structural equation results with three human resources managers who have been successful for not less than seven years in their work. The components consisted of systematic consideration through the following causes: necessary skills; professional skills, work skills, and emotional skills, mediator variables; dynamic capabilities, and organizational performance. This research also discussed five guidelines for developing the necessary skills for performance. As various factors have affected the performance in the new normal era, the human resources executives of five-star hotels in Phuket province should apply them and consider them together with their business plans for setting the strategic plan of organizational management, management, administrative, and human resources development. Doi: 10.28991/HIJ-2023-04-01-03 Full Text: PDF
Análisis de cobertura de medicina prepagada en Pichincha (2019-2020)
Authors: Ortiz – Culcay Oyuki , Fernández - García Carlos , Pérez - Rico Cristina Pérez - Rico
Published: March 2023

La presente investigación tiene como objetivo determinar las empresas sanitarias que se encuentran establecidas y certificadas en la provincia de Pichincha, y analizar la salud prepagada de la zona mencionada. Para ello se examinan los organismos reguladores de la medicina de pago anticipado, clasificándoles en función de su volumen de ingresos y beneficios. A través de este estudio cualitativo se sintetiza el perfil de cobertura sanitaria y su consecuente sostenibilidad económica en relación con su coste-beneficio. El sistema privado tiene un mercado particular con enfoque farmaeconómico que implica una cierta inversión para el cliente con un resultado incierto. En el año 2019 en Ecuador se gastó en salud prepagada 581 millones de dólares que representó aproximadamente un 12% del gasto total en salud. El 80% corresponde a la facturación de la medicina prepagada y el 20% a las primas de las aseguradoras. Estos recursos afectan a la eficiencia del sistema de salud y a la calidad de vida de una parte de la población que busca una mayor utilidad con el mínimo coste posible. Invertir en sanidad es apostar por el desarrollo, en un país con un crecimiento económico casi nulo estos dos últimos años
Revisión Sistemática sobre los desafíos de la educación superior en línea durante la pandemia del COVID-19
Authors: Souza Couto Gontijo da Matta Vanessa , Da Matta Felisberto João Luiz
Published: March 2023

El presente trabajo busca analizar las publicaciones realizadas en 2021, indexadas en la base de datos Science-direct, sobre educación superior en línea, durante la pandemia COVID-19, verificando los desafíos emergentes. Se utiliza una revisión sistemática combinada con el método PRISMA. En un primer momento se identificaron 2909 artículos científicos. Con base en los criterios de elegibilidad, se seleccionaron 5 artículos de revisión. Estos fueron tratados en el programa NVivo y, de la escala de calidad SQUIRE 2.0, se eligieron 4 para la revisión sistemática. Es posible inferir que en 2021, los estudios de revisión sobre educación superior en línea, en el área de ciencias sociales, indican que los desafíos están más concentrados en la órbita de la facultad, sin embargo, los factores que giran en torno al alumnado también deben tenerse en cuenta las relativas a la tecnología de la información.
Gestión estratégica en las pequeñas y medianas empresas en Mozambique
Authors: Cabico Muibo Afonso Vagarecha , Neme Calacich Salvador , Sandoval Caraveo María del Carmen
Published: March 2023

El presente artículo tiene el objetivo de analizar la gestión estratégica adoptada por las pymes, además, efectuar el análisis de su formulación estratégica en el caso concreto de Mozambique y también estudiar en profundidad cómo estás empresas se han gestionado estratégicamente en su entorno. Cabe señalar, que las pymes en general no están estructuradas para una gestión estratégica que pueda ser sostenible, adaptándose al mercado de forma reactiva, en su mayoría estas empresas no son capaces de desarrollar estrategias que les otorguen una ventaja competitiva sostenible en el mercado que operan. Se analizará las pymes en el contexto estratégico, así como los modelos de gestión estratégica que mejor se ajustan a este tipo de empresas, teniendo como bases de soporte revistas y acervo bibliográfico relacionados con el tema.

Palabras clave: gestión; gestión estratégica; pequeñas y medianas empresas
PLAN DE SEGURIDAD PARA PLATAFORMAS WEB EMPLEANDO NORMAS ISO-27001 Y CONSIDERANDO EL OWASP TOP 10-2017
Authors: Pinango Bayas Álvaro Humberto , Méndez Naranjo Pablo Martí , Caiza Méndez Diego Gustavo , Barreno Naranjo Danilo Geovanny
Published: March 2023

La presente investigación se realizó sobre la plataforma web de los servicios del Cuerpo de Bomberos del GAD Municipal de Santo Domingo con el objetivo de detectar vulnerabilidades e implementar un plan de seguridad empleando normas ISO 27001 considerando el listado de riesgos de seguridad de OWASP Top 10-2017, para reducirlas, mitigarlas o eliminarlas. El proceso para las pruebas de penetración y explotación de vulnerabilidades web se lo realizó en 4 fases: recopilación de información, análisis de vulnerabilidades, explotación y generación de informes. Para las pruebas se utilizó las herramientas: Nessus, Vega, BurpSuite, BeEF, Metasploit, Synflood, Hydra y Zenmap. Como resultado se determinó que la plataforma web era vulnerable a: inyección (A1:2017), pérdida de autenticación (A2:2017), exposición de datos sensibles (A3:2017), pérdida de control de acceso (A5:2017), configuración de seguridad incorrecta (A6:2017), uso de componentes con vulnerabilidades conocidas (A9:2017) y registro y monitoreo insuficientes (A10:2017). En base a esta evaluación se creó e implementó un plan de seguridad para la plataforma web. Se ejecutaron pruebas de vulnerabilidades sobre 2 prototipos (Prototipo I: sin plan de seguridad, Prototipo II: considerando el plan de seguridad) de lo que se obtuvo una mejora de la seguridad de la plataforma web en un 75%.
EVALUACIÓN MICROBIOLÓGICA Y SENSORIAL DE UN EMBUTIDO SIN NITRITOS CON FIBRA Y CONSERVANTES NATURALES
Authors: Hidalgo Lisette , Flores María , Yanza Jimmy
Published: March 2023

El achiote (Bixia orellana L.) y el ácido ascórbico se han utilizado para remplazar el nitrito de sodio, como antioxidante y agente antimicrobiano. El objetivo de este estudio fue evaluar las características organolépticas y estabilidad microbiológica de un embutido con fibra realizado bajo el procedimiento de mortadela tipo extra con adición de achiote y ácido ascórbico eliminando el nitrito de sodio de la formulación, para lo cual se trabajó con 4 tratamientos T1(0,1%;0,45g/Kg), T2(0,1%;0,75 g/Kg), T3(0,5%;0,45 g/Kg) y T4(0,5%;0,75 g/Kg) respectivamente. Para el estudio sensorial se realizó una encuesta con escala hedónica de 5 puntos dirigida a 80 consumidores, los datos se evaluaron realizando análisis de varianza y gráfico de medias. Para la estabilidad microbiológica se analizaron coliformes fecales, Escherichia coli, Aerobios mesófilos y mohos y levaduras cada 8 días. Se encontró que T2 tuvo mayor aceptación sensorial seguido de T4, contenidos de mayor ácido ascórbico. Se ajustó la formulación de estos tratamientos, realizando una segunda catación con 7 jueces dando mayor aceptación a T2. Los resultados microbiológicos indicaron que el ácido ascórbico benefició el control microbiano del producto, siendo T2 el que presentó mejor estabilidad manteniéndose dentro de la norma INEN 1338 durante un periodo de 12 días.
ANÁLISIS JURISPRUDENCIAL DE LA FALSEDAD EN EL CHEQUE Y LA APLICACIÓN EN EL CÓDIGO ORGÁNICO INTEGRAL PENAL
Authors: Galarza Christian , Campaña Rodrigo
Published: March 2023

En el caso del cheque, en el ejercicio de la profesión se ha visto muchas argucias en quienes han girado este instrumento, como en el caso de que al firmar el documento suscriben firmas que no concuerdan con la suscrita en la cédula de identidad, esto con el fin de que el cheque se proteste por inconformidad de firma y no se pueda cobrar, esto configura el cargo de que la información contenida en el instrumento no sea verdadera. O se ha dado el caso que se postadata el cheque para que no pueda ser cobrado, lo que configura el cargo de que varíe su sentido de medio de pago a instrumento de crédito, todo esto se presume que se subsumiría en una falsedad ideológica de documento privado, lo cual se podrá verificar con el desarrollo jurisprudencial que se pretende analizar en el presente artículo. El objetivo del trabajo se configura en: Determinar bajo parámetros objetivos jurisprudenciales respecto de la falsedad en el cheque y la aplicación en el Código Orgánico Integral Penal. La metodología se enmarca en la investigación teórico – descriptiva de carácter documental, porque la dimensión práctica de la investigación se llevó a cabo un proceso de escudriñamiento, elección, organización, procesamiento de la información para analizar la falsedad en el cheque y la aplicación en el Código Orgánico Integral Penal. Los resultados se orientan aclarar el panorama en lo siguiente temas: La diferencia entre falsedad y falsificación, los tipos de falsedad, la alteración a la verdad y la prejudicialidad.
Entre lo urbano y lo rural: Un análisis territorial de la realidad de la población rural de la parroquia Juan Montalvo
Authors: Tapia Manuel
Published: March 2023

Este artículo científico de investigación analiza los factores y causas de las políticas públicas de gobernanza relacionada con la implementación de infraestructura necesaria para atender los servicios básicos que el Gobierno Autónomo Descentralizado Municipal del cantón Latacunga le corresponde brindar a la zona rural de la parroquia Juan Montalvo, analizar las acciones y estrategias para resolver la problemática persistente de las necesidades insatisfechas de los servicios públicos básicos como agua potable, alcantarillado y recolección de desechos sólidos, y que actualmente no se ha logrado articular una política integral de atención, sumado el desconocimiento de los ciudadanos del sector rural a los derechos que tienen y al Gobierno seccional le corresponde brindar una atención oportuna que les ofrezca una calidad de vida digna.
Implementation of Naïve bayes Method for Predictor Prevalence Level for Malnutrition Toddlers in Magelang City
Authors: Arumi Endah Ratna , Sumarno Adi Subrata  , Anisa Rahmawati
Published: March 2023

Nutritional status is an important factor in assessing the growth and development rate of babies and toddlers. Cases of malnutrition are increasing, especially in magelang city. Because nutritional problems (Malnutrition) can affect the health of toddlers. Therefore, this study aims to predict the level of prevalence of malnutrition with the Naïve Bayes method. This research uses an observational design, a single center study at the Magelang City Office, using the Naïve bayes method which is used as an application of time series data, and is most widely used for prediction, especially in data sets that have many categorical or nominal type attributes. The Naïve bayes method is used to predict such cases of malnutrition. The results of this study show that the Naïve Bayes method succeeded in predicting the magnitude of cases of malnourished toddlers in Magelang City with an accuracy percentage of 75% due to the very minimal amount of training data, and the areas that have the most malnutrition are in three areas, namely Magersari, North Tidar and Panjang.
TAARA Method for Processing on the Network Forensics in the Event of an ARP Spoofing Attack
Authors: Wijayanto Agus , Riadi Imam , Prayudi Yudi
Published: March 2023

According to reports in 2021 by Kaspersky, requests for investigations into suspicious network activity, such as ARP Spoofing, which can result in sophisticated attacks, reached up to 22%. Several difficulties with examining network systems have been overcome thanks to network forensic investigations. This study aims to perform a network forensic analysis of ARP spoofing attacks using Wireshark forensic tools and Network Miner with a sniffer design process to capture traffic on the router side. In order to gather reliable evidence, this study employs the TAARA method as a network forensic investigation process. Based on the research conducted, it can be demonstrated that an attack took place from eight PCAP files. The information that was gathered, such as the IP address and MAC address of the attacker, the IP address and MAC address of the target, and the date and time of the attack are examples of evidence information that was gathered. This study also shows that network forensic operations can use the Wireshark forensic tool to obtain more detailed data.
TINJAUAN HUKUM ISLAM TERHADAP PERCERAIAN MELALUI GADGET DI LOMBOK UTARA
Authors: Hariati Sri
Published: March 2023

Perceraian merupakan salah satu ujian dalam kehidupan berumah tangga. Hal ini dapat dialami oleh siapa saja tanpa terkecuali. Syara‟ menginginkan pernikahan terjalin kekal antara suami isteri kecuali karena adanya suatu sebab yang tidak dapat dihindari. Salah satunya yakni karena sebab meninggalnya salah satu pihak dan atau yang lainnya. Karena itu pula syara‟ tidak mengikat mati pernikahan dan tidak pula mempermudah perceraian. Syara‟ sendiri telah membenarkan dan mengizinkan perceraian kalau itu lebih dapat memperbaiki kehidupan dari pada tetap mempertahankan ikatan pernikahan. Jenis Penelitian ini adalah penelitian dengan metode empiris. Hasil pembahasan adalah Berdasarkan ketentuan mayoritas ulama dalam hukum islam menyatakan, perceraian melalui SMS sah. Apabila sang suami mempunyai bukti dan alasan kuat untuk menceraikan istrinya namun, hal itu baru sah secara hukum Islam, karena yang terbaik perceraian harus melalui pengadilan agama. Mayoritas ulama merekomendasikan untuk menghindari cerai via SMS. Bahwa bentuk penyampaian talak melalui SMS rawan penyalahgunaan dan memiliki tingkat keakurasian yang lemah Diperbolehkannya perceraian di dalam Islam karena dinamika kehidupan rumah tangga kadang-kadang menjurus kepada sesuatu yang bertentangan dengan tujuan pembentukan rumah tangga itu sebagai landasan filosofis perkawinan sesuai dengan ajaran Islam tanpa mengurangi landasan filosofis perkawinan berdasarkan pancasila yakni merupakan bagian dari aqidah, ubudiah dan muamalah yang berkaitan langsung antara huququllah dan huququlibad.
EDUCAÇÃO AMBIENTAL: UMA PRÁTICA NECESSÁRIA
Authors: SILVA MARCOS ANTONIO BORGES DA
Published: March 2023

A educação ambiental é a ação educativa permanente pela qual a comunidade educativa tem a tomada de consciência de sua realidade global, do tipo de relações que os homens estabelecem entre si e com a natureza, dos problemas derivados de ditas relações e suas causas profundas. O artigo traz uma abordagem sobre a importância da Educação Ambiental na promoção das mudanças de comportamentos tidos como nocivos tanto para o ambiente, como para a sociedade. No ambiente escolar a Educação Ambiental possui grande importância visto que desde cedo as crianças aprendem a lidar com o desenvolvimento sustentável. A escolha por esta proposta se deu em compreender que a Educação Ambiental não deve ser tratada como algo distante do cotidiano dos alunos, mas como parte de suas vidas. É de suma importância a conscientização da preservação do Meio Ambiente para a nossa vida e todos os seres vivos, afinal vivemos nele e precisamos que todos os seus recursos naturais sejam sempre puros. O objetivo central que orienta esse estudo é: Desenvolver nos alunos a consciência dos problemas ambientais e estimulá-los a tentar buscar soluções para estes problemas. A problemática que norteou o a pesquisa, foi: Como a educação ambiental tem sido desenvolvida e inserida no contexto escolar? As ações desenvolvidas são suficientes para a conscientização e mudança de hábitos dos alunos? O presente estudo foi realizado por meio de uma pesquisa bibliográfica, desenvolvida por meio de definição de objetivos a serem alcançados.
Learnscapes for renewable energy education: An exploration of elementary student understanding of solar energy systems
Authors: Cole Laura Brianna , Fallahhosseini Sepideh , Zangori Laura , Oertli R. Tanner
Published: March 2023

Integrating the built environment of the school is one avenue to deliver place-based energy education connecting abstract ideas with the physical environment. This study examined how and if an outdoor classroom (learnscape) with solar panels together with a six-week renewable energy unit supported students in developing conceptual knowledge of energy systems. Fourth grade classrooms from two schools, one with a learnscape and one without, within the same district enacted the unit. Student learning gains (n=97) were measured through model-based reasoning at four time points before, during, and after the unit. Students (n=12) were interviewed about their models. Students in both schools identified the main system components and sequences. However, learnscape students exhibited a more nuanced understanding of solar energy systems and explicitly cited the learnscape as a “teaching tool” for energy education. Findings suggest that the presence of sustainability features on the school campus can enhance student learning outcomes.
Genotype Distribution of Angiotensin I- Converting Enzyme in Iraqi Arab Population
Authors: Al-Awadi Salwa J.
Published: March 2023

The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic which produce three allelic variants: II, ID & DD that associated with population relativity and relation with many genetic disease. The polymorphisms of ACE gene were investigated using polymerase chain reaction. The results showed a high frequency of the DD allele among the Iraqi Arab populations (50%), which is similar to those obtained from previous studies for Arab populations. More ever the distribution of ACE genotype among male and female (n= 100, 53male & 47 female) showed DD: 47.17%, II: 22.6% & ID: 30.19% in the male group and DD: 40.43%, II: 17.02% & ID42.55:% in the female group. Significant association of hypertension & diabetic with D allele of the ACE gene has been in Iraqi Arab population
Comparison between Spinacia Oleracea and FeSO4 as a Source of Iron to Treated Anemia in Mice
Authors: Jabir Abdulwahid Shamkhy
Published: March 2023

I n this study thirty healthy male mice (Swiss albino aged of eight week) were used and divided in five groups. Three groups were feed with bread made of flour containing spinach (three different percentage 10%, 20%, and 30% respectively) as source of iron, compare with group number four which was feed with bread made of flour fortified with premix (consist of FeSO4, Folic acid and Maize starch). It is add according to the information given by the supplier (200g/ 1000 kg flour). Group number five was the control (feed with bread made of unfortified flour). Same food was used during the time of the experiment (fourteen days). The study was designed to make anemia in all groups by injection with phenylhydrazine . Samples of blood were taken by bleeding through heart puncture to measure the hemoglobin (Hb) and the packed cell volume (PCV). At the end of the experiment, mice in all the groups were then sacrificed and slides from the tissues of heart, kidney, liver and spleen had been made to measure the histological effects of these sources of iron. Results showed that there were significant differences in weights, (Hb) and (PCV) between mice feed with bread containing (10%, 20% and 30%) spinach and that containing premix and the control. In the same time slides of harts, kidneys, livers and spleens did not showed any detectable effect.
Advances in the pathogenesis of Alzheimer’s disease: A re-evaluation of the Amyloid cascade hypothesis
Authors: Leo Clinton Chukwu  , John Azubuike Ekenjoku  , Sylvester Chika Ohadoma  , Chinedu Lawrence Olisa  , PC Okam  , Chidinma Cornelia Okany  , Mansur Aliyu Ramalam  , Okoye Chukwuemeka Innocent
Published: March 2023

Alzheimer's disease (AD), the most common cause of dementia in the elderly is a common neurodegenerative disease characterized clinically by progressive memory deterioration. The disease becomes clinically obvious as an insidious higher intellectual function impairment with altered mood and behavior, dramatic personality changes, disorientation, declining physical coordination and inability to care for themselves. Histopathological changes including extracellular deposits of amyloid-beta (A-beta) peptides forming senile plaques (SP) and intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau in the brain. During final stages, victims are bedridden, urinary and bowel function controls may be lost with epileptic attacks. Death is usually due to pneumonia, bedsores or secondary urinary tract infections. These manifestations may indicate severe cortical dis-function. In 5-10 year time, affected individual becomes profoundly disabled, mute and immobile. Death may ensue within an average of 8 years of diagnosis, the last 3 of which are typically spent in institutions. AD is the number one cause of institutionalization in United States of America. An appraisal of the advances in pathogenesis of Alzheimer’s disease will be helpful in updating our knowledge on possible etiologies and desired advancements in therapies, clinical care and entire management. Secondly, with the rising cases of AD in tropical regions of the world and coupled with the significant scarcity of literature on Alzheimer’s Disease, the need for this compendium becomes obviously necessary, hence we chose to write. This very review derives from focused overview of pathophysiologies and management of AD. Literature searches were sourced from PubMed, Science Direct, Scopus and Google Scholar.
Authors: Noviyanti Widya , Umam Nanang Khoirul , Sari Arissona Dia Indah
Published: March 2023

Membaca merupakan salah satu aspek dari keterampilan berbahasa. Keterampilan membaca pemahaman merupakan kemampuan peserta didik pada saat setelah membaca akan memperoleh informasi dan memahami makna yang terkandung dalam teks bacaan. Akan tetapi beberapa peserta didik mampu membaca namun tidak memahami isi dari apa yang telah dibaca. Penerapan strategi KWL (Know-Want to Know-Learned) dapat menjadikan peserta didik aktif saat proses sebelum, saat, dan sesudah membaca, sehingga cocok diterapkan pada pelajaran membaca pemahaman. Penelitian ini merupakan penelitian deskriptif kualitatif yang bertujuan untuk mendeskripsikan proses, hasil dan kesulitan yang dialami peserta didik dalam penerapan strategi KWL (Know-Want to Know-Learned) saat proses pembelajaran. Pada penelitian ini menggunakan teknik pengumpulan data berupa tes, wawancara, observasi dan dokumentasi. Sedangkan analisis data pada penelitian ini berupa reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukan aktivitas peserta didik pada pertemuan kedua sudah mampu mengikuti langkah-langkah KWL daripada saat pertemuan pertama. Kemudian terdapat 6 dari 8 peserta didik yang memiliki keterampilan membaca pemahaman yang cukup baik dan terdapat 2 dari 8 peserta didik yang keterampilan membaca pemahamannya masih kurang. Kesulitan yang dihadapi peserta didik adalah saat membuat kesimpulan dari isi teks bacaan dan ada beberapa peserta didik yang juga mengalami kesulitan saat mengisi kolom pada lembar kerja KWL
Authors: Komariyah Nurul , Subayani Nataria Wahyuning
Published: March 2023

Pendidikan karakter merupakan pendidikan yang menanamkan dan mengembangkan karakter kepada peserta didik, menerapkan dan mempraktikkannya dalam kehidupan baik di lingkungan sekolah, keluarga dan masyarakat. Penanaman karakter ini dilakukan melalui kegiatan ekstrakurikuler pramuka. Tujuan dari penelitian ini adalah untuk mengetahui karakter moral dan perilaku peserta didik melalui kegiatan ekstrakurikuler pramuka di kelas IV UPT SD Negeri 112 Gresik yang berjumlah 10 peserta didik yaitu lima laki-laki dan lima perempuan. Jenis penelitian ini adalah penelitian deskriptif kualitatif. metode pengumpulan data dengan observasi, wawancara dan angket. Hasil penelitan ini menunjukkan bahwa pendidikan karakter yang dilaksanakan melalui kegiatan ekstrakurikuler pramuka diharapkan mampu menciptakan karakter moral yang mencakup nilai religius, jujur, disiplin, mandiri, tanggung jawab, dan peduli sosial. Dengan adanya pendidikan nilai-nilai moral peserta didik melalui ekstrakurikuler pramuka diharapkan peserta didik mampu memahami nilai-nilai kepramukaan misalnya, tolong menolong, mandiri, disiplin, dan tanggung jawab dan dapat menjadikan sebagai pribadi yang lebih baik serta dapat diterapkan dalam kehidupan sehari-hari.