bluuebunny/crossref_metadata_2025 huggingface dataset:
Влияние социокультурных факторов на развитие профессиональной направленности будущего педагога
Authors: Киртава Г.Т.
Published: October 2023

В статье исследуется феномен профессиональной направленности будущего педагога как личностного качества, отличающегося динамизмом, развитием, изменением. В работе определены основные уровни профессиональной направленности, формирующие профессиональное самосознание будущего педагога: образ Я-личности, образ профессии педагога, профессиональный образ Я. Даны подробные характеристики влияния социокультурных факторов на каждый из уровней профессиональной направленности.
Механизмы управления формированием воспитывающей среды ДОУ в соответствии с требованиями Федеральной образовательной программой дошкольного образования
Authors: Семеняк О.А.
Published: October 2023

Автором рассматривается проблема управления формированием воспитывающей среды ДОО в соответствии с требованиями Федеральной образовательной программой дошкольного образования. Дан обзор актуальных нормативных документов, регламентирующих процесс управления в ДОО. Представлены и описаны механизмы управления формированием воспитывающей среды ДОУ.
Применение информационных технологий для решения стереометрических задач
Authors: Смирнова А.С. , Савченко Н.А.
Published: October 2023

В статье представлен сравнительный анализ программных продуктов, используемых для построения динамической геометрии: Математический конструктор, Живая математика, программа GeoGebra.
Pseudorutile-leucoxene-quartz ores of Timan ‒ a new genetic type of titanium raw materials: prospects for industrial development
Authors: Makeyev Alexander B. , Skublov Sergey G. , Galankina Olga L. , Vasiliev Evgeny A. , Krasotkina Anna O.
Published: October 2023

The two largest deposits of Russia – Yaregskoye and Pizhemskoye belong to the same genetic type; hydrothermal-metamorphic indigenous deposits. They are located in the same Timan structure at a distance of no more than 230 km from each other. According to the total approved reserves and forecast resources of titanium dioxide, they are approaching 60% of the all-Russian and will form the basis of industrial titanium raw materials used in Russia in the near future. In the interests of technological mineralogy, morphological features, internal structure, chemical composition of grains of the two main titanium mineral phases ‒ leucoxene and pseudorutile, TiO2 polymorphs, as well as the composition of mineral microinclusions in these phases have been studied in detail. The compositions of all mineral phases in polished preparations of leucoxene and pseudorutile were analyzed by SEM-EDS method at the Institute of Geology and Geochronology of the Precambrian of the RAS, 147 chemical analyses were obtained at the point (3 µk) and many images of polished grains of anatase, leucoxene and pseudorutile were scanned over the area (20×20 µk). In the leucoxene grains themselves, 12 mineral phases were diagnosed and characterized in the form of inclusions: pseudorutile, rutile, anatase, quartz, hydromuscovite-illite, kaolinite, siderite, zircon, xenotime, pyrite, florencite, monazite and kularite. TiO2 polymorphs are verified by Raman spectroscopy and X-ray diffraction analysis. New evidence has been obtained that the transformation of ilmenite into leucoxene occurs hydrothermally through intermediate phases ‒ Fe-rutile and pseudorutile; the enlargement of rutile crystals in the leucoxene grain itself is shown; the presence of secondary crystals of siderite, florencite and others inside the studied grains.
Efficiency of enhanced oil recovery’s and oil production stimulation’s methods at the oil fields of Khanty-Mansi Autonomous Okrug – Yugra
Authors: Kuzmenkov Stanislav G. , Korolev Maksim I. , Novikov Maksim V. , Palyanitsina Alexandra N. , Nanishvili Olga A. , Isaev Valery I.
Published: October 2023

Stabilization of oil production at the level of 215–220 million tons/year, as well as its subsequent growth, is a priority task for the enterprises of the fuel and energy complex of Khanty-Mansi Autonomous Okrug – Yugra (KhMAO – Yugra). It is impossible to achieve this without the active implementation of the most effective modern technologies for enhanced oil recovery. This article aims to analyze the methods of enhanced oil recovery and oil production stimulation methods (EOR and PS) used at the KhMAO – Yugra fields on an industrial scale, their features and their contribution to additional oil production from 2001 to 2021.

The article describes such technologies as sidetracking (STB), physical and chemical methods (FCM), hydraulic fracturing (HF), bottom-hole treatment (BHT), hydrodynamic methods (HDM), horizontal well drilling (SHD), as well as other geological and technical measures (GTM) aimed at optimizing well operation (other methods (OM)). The study showed that FCM, BHT and other well interventions became the most used. The share of additional oil produced through the use of EOR and PS has doubled since 2013: 8% in 2013, 16.2% in 2021. Hydraulic fracturing, deep drilling and sidetracking showed the highest efficiency. All this led to the stabilization of the annual oil production in KhMAO – Yugra and even to its growth in 2021.
The use of enhanced oil recovery methods on a non-alternative basis in developed fields is especially important, because the share of hard-to-recover reserves is high and reaches 80% for some companies in the Khanty-Mansi Autonomous Okrug – Yugra. For such fields, it is necessary to strengthen scientific research in the field of substantiation of optimal conditions for well construction, as well as the operation of development systems.
Physics of gravitational processes as a key to understanding the properties of Achimov deposits
Authors: Osipova Marina V.
Published: October 2023

The article is devoted to the development of a methodology for predicting the properties of Achimov reservoirs based on cause-and-effect relationships such as the source of shelf sedimentary material, the geometry of clinoforms and the distance of alluvial fans to the slope. The technique was developed on the basis of physical laws, namely the conditions of disturbance of the gravitational equilibrium of sediments on the shelf edge – the moment of the beginning of the removal of sedimentary material and the process of cone formation caused by the deposition (braking) of sediments on the bottom of the basin. The methodology includes two stages for step-by-step theoretical justification and ease of understanding. At the first stage, the problem of disturbing the gravitational equilibrium of shelf sediments depending on the geometry of the clinoforms is solved. At the second stage, the problem of dependence of the distance of the blades on the slope and the properties of promising objects is considered. Based on theoretical concepts, the main conclusions about the dependence of the characteristics of alluvial fans (properties and volume of sandstone) on the geometric parameters of clinoforms and on the distance to the slope are outlined, and a complex parameter characterizing the properties of promising objects is derived. The methodology developed by the author makes it possible to predict, compare and rank Achimov objects according to their prospects both within one formation and as a whole in one or several fields.
Sequence stratigraphic model as a modern tool for seismic data interpretation
Authors: Potapova Elena A.
Published: October 2023

The sequence stratigraphic models for the clinoform part of the section in the territory studied by production drilling within the Nadym-Pur oil and gas region of Western Siberia are constructed. The purpose of study was to identify patterns in the distribution of reservoir properties of the Achimov objects and substantiate a systematic approach to the correlation of reflecting horizons. The main task is to identify the characteristic features of systemic tracts based on core data from a well-studied field. To solve the problem, a classification of sediments studied by core in wells was carried out within the framework of a sequence model. To confirm theoretical concepts about the formation of improved reservoir zones in system tracts, an analysis of filtration and capacitance parameters (porosity, permeability) was performed. There is the relationship between the reservoir properties and the type of system tract in which the deposits were formed. The seismic section requires the interpretation according to the principles of sequence stratigraphy, and criteria for tracing reflecting horizons. An algorithm for constructing a model is proposed that provides a forecast of zones with improved reservoir properties. A number of advantages for the unsystematic approach to correlating reflecting horizons are given.
Features of the geological structure of the Achimov complex of the Yarudeisky megaswell (Western Siberia)
Authors: Osipova Marina V. , Shakirov Ravil R. , Koshcheev Andrey G. , Pisarchuk Sergey V. , Naymushin Anton G. , Nesterov Oleg P.
Published: October 2023

This work is devoted to the peculiarities of sedimentation and geological structure of clinoform deposits of the Yarudeisky megaswell (Western Siberia). The main feature of the clinoforms under consideration is that the sediments are confined to the marginal regional clinocyclite of the western dip of the area of oncoming clinoforms, formed in relatively shallow sea conditions and differing from deep-sea clinoforms by pinching out not onto the Bazhenov formation or the early underlying clinoforms of the western dip, but by stopping their spread along the path of movement of the oncoming clinoforms eastern dip. The study of the counter clinoforms of the Yarudeisky megaswell is based on a regional analysis of the structure of cross-layered deposits in conditions of extremely poor knowledge of the study area. Within the framework of western dipping clinoforms, possible oil and gas potential prospects for the Achimov complex within the boundaries of the Yarudeisky megaswell are identified.

As a result of the analysis of geological and geophysical data, the boundaries of the distribution of opposing clinoform complexes in the study area were determined. The existing paleo-geomorphological conditions that contribute to the accumulation of sandstone with improved properties in the designated seismic complexes are presented. The fields of the Nadym oil and gas bearing region with the proven productivity of the Neocomian clinoform complex are indicated, which confirms the oil and gas potential of the region and suggests favorable conditions for the accumulation of hydrocarbons in the study area.
Hydrocarbon prospectivity of pinch-out zone of Jurassic deposits in Southwestern part of South Taimyr Monocline
Authors: Igonin Ivan S. , Zyza Evgeniy A. , Kuleshova Irina Yu. , Zherzhova Polina E. , Kiryanina Anna V. , Bondarev Andrey N.
Published: October 2023

A comprehensive analysis has been conducted on the geological structure of the entire Jurassic interval within the southwestern part of the South Taymyr Monocline, which has allowed a more precise understanding of the structure of the Khabei gas field and the identification of prospective objects of similar geological pattern. The study utilized CDP 2D seismic data, covering a total length of 7835 kilometers, as well as results from exploratory and appraisal drilling. Based on visual analysis of temporal cross-sections, an assumption has been made regarding the correlation between reservoir development zones and paleo-channel systems of the Lower-Middle Jurassic deposits. In order to identify and locate such systems, an analysis of temporal cross-sections, maps of total Jurassic deposit thickness, and maps of dynamic attributes were conducted. As a result, areas of development of large paleo-channel systems (paleo-valleys) within the South Taymyr Monocline have been delineated through integration. These identified zones are characterized by relatively shallow burial depths of up to 2.5 km, the absence of abnormally high reservoir pressures (AHBP), and comparably high filtration-capacity properties for Jurassic reservoirs (porosity – 22%, permeability – 25–50 mD).
However, considering the complexity of these objects’ structures and the uncertainties caused by the low degree of geological-geophysical exploration in the study area, it is recommended to conduct additional seismic surveys (CDP 3D) to maturate the objects for exploration drilling.
An insight into the structure and functions of flabelliferins and borassosides; nutraceuticals in Asian palm (Borassus flabellifer)
Authors: Alexis Thayaparan Christine Thevamirtha , Kuldeep Sweety Angela , Dewanjee Supriya , Kazi Esha , Tharmalingam Sarjana , Dhanaraj Premnath , Paulraj Mosae Selvakumar
Published: October 2023

Palmyraculture is a sustainable livelihood, in which people structure their lifestyle utilizing the values of Palmyra palm. The Asian Palmyra palm, Borassus flabellifer, gives a lot of nutritional and nutraceutical products, as it is rich in vital biomolecules, especially flabelliferins and borassosides. Flabelliferins are found in the fruit, tuber, and inflorescence of Palmyra palm, and the borassosides are found in the inflorescence. There are 14 types of flabelliferins (only nine of their structures are known) and six types of borassosides have been extracted so far. Flabelliferin F-II reduces intestinal glucose uptake and is anti-diabetic, and antiobesitic. Flabelliferin FB is antimicrobial, an inhibitor for SARS-CoV main proteinase, SARS-CoV main protease, and human cellular transmembrane serine proteinase, and Borassoside E is antifungal. Further studies have to be conducted to determine the structures and functions of the other flabelliferins and borassosides.
《食品营养化学》创刊词
Authors: 刘礼兵
Published: October 2023

食物是人类赖以生存和健康发展的基础。人需要每天进食，通过消化、吸收和代谢等生物化学过程从食物中摄取所需的营养物质，促进机体生长和发育。随着对健康和营养关注度的不断提高，人们逐渐意识到食物中所含的营养物质对我们的身体功能和整体健康至关重要。而深入了解食物的营养成分、功能以及化学相互作用对于我们制定合理的饮食计划、预防疾病、维持健康至关重要。食品营养化学是一门综合性交叉科学，关注食物中所含的营养物质及其对人体健康的影响，在生命健康领域中扮演着重要角色。
山药化学成分及其生物活性研究进展
Authors: 葛梦焕  , 阮元  , 刘淼  , 王丽  , 文春南  , 麻兵继
Published: October 2023

山药为著名的药食同源植物，含有多糖、茋类、二苯庚烷、甾体、木脂素和萜类等化学成分，具有显著的抗氧化、增强免疫和降血糖等多种生物活性。本文综述了近年来山药的化学成分及其生物活性研究进展，为进一步促进山药的开发利用提供参考依据。
利用太赫兹光谱和氧化石墨烯传感器实现对芒果皮上农药残留的高灵敏度检测
Authors: 王希祖  , 杨爵远  , 张楠  , 邢珍相  , 朱强  , 柯琳
Published: October 2023

在农业农田中定期监测农药是防止有毒农药化学品滥用的关键。由于通常需要分解农作物样本以提取农药残留物以进行色谱分析，因此寻找非破坏性的农药监测技术对于防止不必要的农作物破坏至关重要。然而，这需要具备能够检测微量农药的分析技术。在本篇文章中，我们展示了太赫兹（THz）光谱在衰减全反射模式下与低成本的氧化石墨烯（GO）等离子传感器相结合，可用于对芒果皮上的农药进行敏感、快速且非破坏性的检测。在将农药溶液涂抹在芒果皮上后，通过将其与芒果皮表面接触并施加压力，将干燥的农药残留物转移到了氧化石墨烯传感器上。由于农药分子吸附到富含氧的氧化石墨烯表面上，因此获得了在太赫兹范围内对应于农药化学指纹的信号。借助这种技术，可以检测到芒果皮上约1 µg/cm2的农药表面浓度。
Design tools and models
Authors: Daborer-Prado Nayrana , Neyer Daniel , Aye Lu , Jakob Uli
Published: October 2023

This is the final report on activity C1, “Design tools and models” of the IEA SHC Task 65 “Solar Cooling for the Sunbelt regions”. The work involved reviewing and adapting tools and models for technical and financial assessment and design for solar cooling and the project phases from pre-feasibility to simulation to monitoring. The main focus is the documentation of the tools and their specific application to provide measured data for validating the tools and the adaptation of selected ones for Sunbelt countries.
Quantification of Urinary Exosome Sex Hormone Binding Globulin Levels during Estrus and Diestrus Stages of Buffaloes
Authors: Varra Manasa , Kumar V. Girish , Chandranaik B.M. , Kumar M.T. Sanjeeva , Sundaresan N.R. , Sejian Veerasamy , Sudha G.
Published: October 2023

Background: The efficiency of reproduction in buffaloes can be increased by being able to spot buffaloes in estrus, as silent heat is a severe problem in this species. Proteins of urinary exosomes are identified to be better physiological biomarkers when compared to cell free proteins as these extracellular vesicles (EVs) are tiny in size, have additional protection from degradation by endogenous protease activity and are involved in intercellular communication. Hence, the present study was aimed to quantify the urinary exosome sex hormone binding globulin (SHBG) levels during estrus and diestrus stages of buffaloes to determine its suitability as a marker for identifying buffaloes in estrus. Methods: The grouping of animals as mid-diestrus (Group-I/G-I/Control group), regular estrus (Group-II/G-II) and silent estrus (Group-III/G-III) buffaloes was done using a combinatorial approach. The levels of SHBG in urinary exosomes of three groups of animals was quantified using the bovine SHBG ELISA kit. Result: The present study’s findings showed significantly higher urinary exosome SHBG concentration (p less than 0.05) in G-I in comparison to G-II and G-III. The present study revealing for decreased concentration of urinary exosome SHBG in G-II and G-III animals when compared to G-I animals probably construes the physiological role of SHBG in the female reproductive tract at the estrus stage by mediating the action of estradiol 17 â (Eα) at the target site. However, for urinary exosome SHBG to be considered as a biomarker, there is need for additional research on a bigger population.
Studies on Leaf Characteristics of Chickpea (Cicer arietinum L.) and Their Contribution to Seed Yield under Different Temperature Stress in North West India
Authors: Kumar Ajeev , Kumar Neeraj , Devi Sarita , Dhaka Anil Kumar , . Preeti
Published: October 2023

Background: Temperature stress (heat or cold) is becoming a major area of concern due to climate change affecting crop production worldwide. Chickpea leaves are most sensitive to variation in temperature so any variation in temperature (High or Low) causes substantial losses in yield due to disruption in physiological processes of the plant cell. Therefore to achieve maximum production under current scenario of climate change a better understanding of stress induced responses in leaves of chickpea and interrelationship between seed yield and leaf traits can prove to be useful. Methods: The field trials was conducted with ten genotypes of chickpea for two consecutive years (2017-2019) at Pulses Section, Chaudhary Charan Singh Haryana Agricultural University, Hisar to study various traits of leaf at 50% flowering stage (80-90 DAS). Temperature stress (cold or heat) was given by manipulating the sowing dates that is 15th October (early sown condition in Haryana), 15th November (Normal sown condition in Haryana) and 15th December (late sown condition in Haryana). Data were recorded when temperature was ( less than 5°C for 7 days) in early sown and ( greater than 35°C for 7 days) in late sown crops. Result: Results indicated that early sown crops experienced low temperature stress in the month of December-January while late sown crops showed high temperature stress in the month of March- April. The maximum values of leaf parameters were found in crops sown on 15th Novemberand minimum in15th December sown crops and no significant differences in seed yield was recorded between 15th October and 15th November sowing, however, further delay in sowing to 15th December showed significant reduction in seed yield. Among genotypes maximum leaf parameters and seed yield were observed in H12-64 and H13-01 while minimum were found in H14-04. Seed yield exhibited significant positive correlation with all traits in 15th October and 15th November sowing while non-significant was on 15th December sowing.
Advances in connectivity and distributed intelligence in agricultural robotics
Authors:   Natural Resources Institute Finland (Luke), Finland, Pesonen Liisa , Calvo Alonso Daniel ,   Atos, Spain, Backman Juha ,   Natural Resources Institute Finland (Luke), Finland, Kaivosoja Jere ,   Natural Resources Institute Finland (Luke), Finland, Recio Martinez Jarmi ,   Atos, Spain, Soininen Juha-Pekka ,   VTT Technical Research Centre of Finland, Finland
Published: October 2023

Robotics needs to evolve in capabilities for collaborative operations within farm worksites like fields and barns. Especially, from the viewpoint of smallholders, it is necessary to be able to use robots as a service. This, however, sets a demand for robots and their management systems to be able to adapt to customer farms’ diverse farm technology assets. The concept of Internet of Robotic Things defines robots as Internet of Things systems which exploit cloud services to increase calculation, data storage and analytics capacities, i.e. BigData analytics. The main advances in connectivity and distributed intelligence of robotic systems in agriculture are multi-robot systems that are capable to collaborate with other farm machinery, sensing and Farm Management Information Systems. They are enabled by low-latency communication networks, edge computing deploying Machine Learning and IoT data sources, and Data Space for creating needed data connections to versatile supporting services and data sources.
Lead Reduction on Polluted Water and Sediment through The Use of Anadara granosa shells and Monostroma nitidum Biological Filters
Authors: Alamsjah Mochammad Amin
Published: October 2023

Industrial waste water treatment holds a very vital role in filtering toxic materials and improving the quality of industrial waste water before being released into public waterways, so that the water ecosystem balance can be maintained. This study aims to identify Pb concentration on polluted water and sediment from an offshore oil drilling area near Camplong Beach, Madura, and also make efforts to find out the potential Anadara granosa shells and Monostroma nitidum seaweed biofilters that exist in that place so as to suppress the adverse effects of toxic materials that arise. The method used was experimental research design that aims to systematically obtain information to describe a lead concentration on polluted water and sediment, and also evaluate the presence of A. granosa shells and M. nitidum as a potential biological filter. The results of the analysis of lead in A. granosa shells, M. nitidum biofilter, water, and sediment indicated that there was a significant correlation, where the shells of A. granosa and M. nitidum can absorb lead until 36.59% and 8.79%, respectively, from which the initial concentrations of lead in sediment and water were 5.57±1.58 and 0.004±0.001 mg/kg respectively. The existence of algicidal substances of HDTA, ALA, and ODTA from M. nitidum can suppress the growth of dinoflagellatas of Chattonella marina. The quantification analysis of fatty acid composition showed that M. nitidum is dominated by PUFA as much as 66% of total fatty acid, and has algicidal substances of HDTA, ALA, and ODTA of 61.53 mg/100 g.
EtCO2 Levels in Medical Students Wearing N95 Masks
Authors: Madubun Safira Eka Putri , Angkejaya Ony Wibriyono , Que Bertha Jean , Lima Felmi de , Titaley Christiana Rialine
Published: October 2023

Introduction: N95 masks are very popular for daily use and can actively filter microparticles such as viruses. However, there are concerns that prolonged wearing of the mask may result in exhaled CO2 accumulation between the face and the mask, which may cause increased end-tidal carbon dioxide (EtCO2) levels and physiological changes. This study aimed to determine EtCO2 levels in students wearing the N95 mask.
Methods: This was an experimental study with a case-control design. The subjects were divided into a treatment and a control group and were subjected to five measurements in 120 minutes. The data were analyzed using the independent samples T-test (normally distributed data) and the Mann-Whitney U test (not normally distributed data).
Results: Mann-Whitney test at minute 0 showed that p = 0.010, independent sample T-test at minute 30 showed that the control group p = 0.016, while in the treatment group p = 0.019. Independent sample T-test at minute 60 for the control group p = 0.034, while the treatment group p = 0.037. Independent sample T-test at minute 90 for the control group and treatment p = 0.001, and independent sample T-test showed that at minute 120 in the control and treatment groups p = 0.000.
Conclusion: The EtCO2 measurements at each of the five time points showed a statistical difference (p < 0.05). However, medical students who wore an N95 mask did not suffer adverse effects because the EtCO2 values in the control group were higher than in the treatment group.
Effects of E-Cigarette Vapor Smoke on Pulmonary Alveoli in Rattus norvegicus Lungs
Authors: Wiriansya Edward Pandu , Rahman Dewi , Zuhair Muhammad Naufal , Rijal Syamsu , Ikram Dzul , Pangnguriseng Utomo Andi
Published: October 2023

Introduction: Vapor is considered a safer alternative to tobacco cigarettes because the high nicotine content is less. However, vapor still contains substances that are classified as toxic to humans. Short-term exposure to vapors from liquids can induce an inflammatory response in the lungs and cause oxidative stress. This study aimed to determine the effects of e-cigarette vapor smoke on pulmonary alveoli in Rattus norvegicus lungs.
Methods: This was an experimental study on 32 adult male Rattus norvegicus rats. They were divided into two groups exposed to nicotine-containing vapor smoke two times a day for one and three months, respectively, and one group as control. After vapor exposure, the lung tissues of the rats were taken and then subjected to histopathological examination under a microscope.
Results: After exposure for one month, epithelial and endothelial cells degenerated, characterized by a decrease in collagen and elastin fibers in the extracellular matrix. For three months, there were changes, the alveolar membrane had no nucleus, the surrounding endothelial cells were not visible due to damage to the extracellular matrix, the alveolar lumen had widened, causing edema in the lumen of the alveoli, and the alveoli wall was destroyed. Therefore, the connection between the alveoli was stretched.
Conclusion: This study found that short-term exposure to nicotine vapor causes damage to the alveoli membrane.
Holistic Management of Pediatric Patients with Asthma through the Family Medicine Approach: A Case Series
Authors: Putera Azwin Mengindra , Octaviana Dinda Sella , Gunawan Fanny , Kunigara Manika Putri , Rahmatsani Junjungan Nimasratu , Kurniawati Lavenia , Bramasta Ferrel , Istianah Istianah , Pranjasdhina Jihan Nabila , Davis Gerald Sebastian , Assabella Ashfa Diniyya , Ramadhan Akbar Rizky , Krismaningrum Veronika Intan , Harmadha Wigaviola Socha Purnamaasri
Published: October 2023

Introduction: Asthma is a global problem, with around 100-150 million people estimated to suffer from this disease. Based on data from the Centers for Disease Control and Prevention (CDC), around 8.4% of people in the United States suffer from asthma. Asthma requires holistic treatment, one of which is family medicine. However, there is a lack of data or research discussing this matter. Hence, this case report aims to provide an overview of family medicine in asthma, especially in children.
Case: This study is a case series report involving four pediatric patients with asthma. Data collection was performed by conducting home visits and hetero-anamnesis. Many things affect asthma treatment apart from pharmacology, including family medicine. In this case series, the role of the family proved significant in the patient's healing and daily functioning.
Conclusion: Family medicine is a type of holistic management critical in various diseases, especially asthma. Support from the patient’s family and environment has an essential role in the success of asthma therapy in children.
Lung Cancer: A Literature Review
Authors: Sembiring Yan Efrata , Effendi Wiwin Is , Dillon Jeffrey Jeswant , Soebroto Heroe , Winarno Dhihintia Jiwangga Suta , Puruhito Puruhito , Putra I Gusti Agung Made Adnyanya , Sebayang Abed Nego Okthara , Negoro Sri Pramesthi Wisnu Bowo
Published: October 2023

Lung cancer is a cancer whose onset starts in the lungs where there is an abnormal cell growth that is very fast and uncontrolled. The abnormal cell growth is triggered by deoxyribonucleic acid (DNA) damage, including deletions in the DNA section, inactivation of tumor suppressor genes, activation of proto-oncogenes to oncogenes, the absence of apoptosis, and the activity of the telomerase enzyme. Lung cancer is initiated by oncogeneous activity and inactivation of tumor suppressor genes. Oncogenes are genes that help cells grow and divide and are believed to cause a person to develop lung cancer. In general, lung cancer is divided into two types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). World Health Organization (WHO) classifies lung cancer based on histopathology into 4 major cell types, namely SCLC, NSCLC which includes adenocarcinoma, squamous cell carcinoma (SCC), and large cell carcinoma (LCC). The difference between the two is that SCLC has a higher aggressiveness than NSCLC. Cancer treatment is based on the type, size, location and stage of the cancer, as well as the patient's overall condition.
Seagrass ecosystem biodiversity mapping in part of Rote Island using multi-generation PlanetScope imagery
Authors: Wicaksono Pramaditya , Harahap Setiawan Djody , Hafizt Muhammad , Maishella Amanda , Yuwono Doddy Mendro
Published: October 2023

Remote sensing offers an effective and efficient solution to provide information on the biodiversity of seagrass ecosystems, which is currently lacking in most parts of the world. Therefore, this study aimed to map the biodiversity of seagrass ecosystems in parts of Rote Island, which is one of the seagrass biodiversity hotspots, using multi-generation PlanetScope magery to see how they compare. The most frequently used biodiversity indicators were identified, including the major benthic habitat (coral, seagrass, macroalgae, bare substrate) and the composition of seagrass species based on life forms. We also aim to understand the actual biodiversity indicators of seagrass ecosystems captured by PlanetScope imagery. To achieve this, field data was integrated with the resulting ISODATA classification results to assess what ISODATA class clusters represent in the field, and new classification schemes are developed accordingly. The random forest algorithm was used to carry out the classification, with seagrass field data serving as training data. Independent field data was subsequently used to assess the accuracy. The results showed that the accuracy of benthic habitat and seagrass mapping ranged from 60%-70%. However, through the use of a classification scheme built on ISODATA clustering, the spatial distribution of classes and accuracy of all PlanetScope images was significantly improved to > 90%. This highlighted the importance of understanding which indicators of seagrass biodiversity were effectively captured by PlanetScope images to achieve higher mapping accuracy. Overall, this approach optimized the ability of PlanetScope images to map seagrass biodiversity while obtaining a higher number of biodiversity indicator classes and mapping accuracy than the commonly used biodiversity indicator classification scheme.
Aneurysmal Subarachnoid Hemorrhage in Young Adult Patients: Single Center Reports
Authors: Ji Seung-Hoon , Hwang Sung-Kyun
Published: October 2023

Objective: The mechanisms underlying the formation and rupture of intracranial aneurysms in young adults remain a matter of debate. This study aimed to evaluate the clinical characteristics of young adult patients with aneurysmal subarachnoid hemorrhage (SAH) treated with endovascular or clipping techniques at a single center.Methods: Seventeen young adult patients (age, 18–40 years; 7 men and 10 women; mean age, 35.7 years) with aneurysmal SAH were treated at our hospital using an endovascular or clip ligation approach between February 2018 and March 2023. The clinical outcomes, complications, and patient characteristics were evaluated. The mean follow-up duration was 13 months (range, 0–44 months).Results: The male-to-female ratio was 0.7 (7 vs. 10 patients), and the most common location of aneurysm was the internal carotid artery (7 patients, 41.2%). Two patients (11.8%) presented with a history of hypertension, and six (35.3%) with smoking. The overall favorable outcome rate was 64.7% (Glasgow Outcome Scale [GOS] 4 and 5), while unfavorable outcomes occurred in 35.3% of patients (GOS 1, 2, and 3). None of the patients rebounded after clipping or endovascular treatment. Two (14.3%) patients treated with coil embolization (14 patients) showed an interval change in the residual neck (recanalization).Conclusion: Our results suggest that young adults with ruptured intracranial aneurysms exhibit different characteristics. However, well-controlled investigations using larger prospective studies are warranted to further clarify the clinical characteristics of these patients, including the mechanisms of aneurysm formation and rupture.
Prognostic and Immunological Significance of Immune Infiltration-Related Gene Signature in Stomach Adenocarcinoma
Authors: Qian Peng , Zhang Qian , Zuo Feijie , Zhang Jingyi , Wang Xinhui , Xu Xianjing , Liu Kaikun , Huang Gairong , Cao Xuanchao
Published: October 2023

Two datasets were employed in the study: a training dataset comprising 375 samples from The Cancer Genome Atlas (TCGA) and a validation dataset consisting of 300 samples sourced from the Gene Expression Omnibus (GEO) database. The study employed single sample gene set enrichment analysis (ssGSEA) to categorize patients into high and low immune cell infiltration groups based on immune scores derived from the ESTIMATE algorithm. The study identified overlapping genes that exhibited differential expression between tumor and normal samples, as well as between a high immune cell infiltration group (Immunity-H) and a low immune cell infiltration group (Immunity-L). These genes, referred to as differentially expressed immune infiltrated genes (DEIIGs), were selected and utilized to create a prognostic signature for DEIIGs. The developed signature was subsequently validated using the provided validation dataset. The research identified a prognostic signature consisting of nine differentially expressed immune infiltrated genes (DEIIGs): LINC00843, ADH4, ANGPT2, APOA1, ASLC2, GFRA1, KIAA1549L, MTTP, and PROC. The study found that the presence of B cells, T cells CD4+, neutrophils, macrophages, and myeloid dendritic cells positively correlated with the prognosis of STAD (stomach adenocarcinoma). Conversely, CD8+ exhibited a negative correlation with the prognosis of STAD. By performing immunohistochemistry (IHC) staining, we observed that ADH4 expression was lower and ANGPT2 expression was higher in STAD tissues compared to normal tissues. In conclusion, this study provides a potential prognostic tool for predicting the survival of STAD patients based on the expression of immune-related genes.
Modeling of a linear Fresnel direct steam generation solar thermal power plant with sensible-latent hybrid thermal energy storage: A case study for Northeastern Brazil
Authors: Ferreira Willian Mendes , Martins João Humberto Serafim , Júnior Jorge Alberto Lewis Esswein , Filho Victor César Pigozzo , Passos Júlio César
Published: October 2023

This study aims to model a linear Fresnel reflector concentrated solar power plant to assess its potential for electricity generation in Northeastern Brazil, where the annual direct normal irradiation exceeds 2,000 kWh m-². Time-series simulations were performed using EBSILON Professional. The modeled plant consists of three subsystems: (a) a solar field, where superheated vapor is generated at 550°C and 107 bar, (b) a sensible-latent hybrid thermal energy storage with a capacity of six hours, and (c) a 30 MWe power block. From annual plant simulation, the profiles for electricity dispatch, capacity factor, and solar-to-electric efficiency for one year are obtained. The results showed an even distribution of the monthly power output, although the generation is higher during the dry season (April to September) than the wet season (October to March). The opposite occurs to thermal energy storage: the stored energy is more relevant during the dry period. Thus, the satisfactory performance of the proposed storage system and the solar-to-electric efficiencies obtained suggest direct steam generation and sensible-latent storage integration could play an important role in enabling concentrated solar power plants using linear Fresnel reflectors to be competitive in the Brazilian energy market.
Direct Medical Costs in the Care of Pediatric Patients with Non-Syndromatic Epilepsy: Using Levetiracetam and Valproic Acid
Authors: Pérez-Lozano Diana Leticia , Carmona-Aparicio Liliana , Torres-Vázquez Marcos , Puente Silvestre García-de la , Palma-Barona Miriam , Martìnez Perla Michelle , Juárez-Zepeda Tarsila Elizabeth , Coballase-Urrutia Elvia , Rivera-Espinosa Liliana , Montesinos-Correa Hortencia , Ruíz-Garcìa Matilde
Published: October 2023

Background
The costs of treatments and medical technologies are variables health professionals and institutions can use in guiding decision-making and the improvement of health systems. Currently, few studies that address the economic impact of the clinical-therapeutic management of pediatric patients with epilepsy. This study aimed to determine the direct medical costs of the main monotherapies used in the pediatric population with nonsyndromatic epilepsy.
Methods
Observational, retrospective, longitudinal study, by capturing data and entering the database corresponding to the study variables from the records of patients who met the inclusion criteria, in a period of 10 years, and with an annual time horizon. Costs were determined by the microcosting method.
Results
400 complied with monotherapy therapy, in whom valproic acid (VPA, 46%) and levetiracetam (LEV, 25%) were the most prescribed antiepileptic drugs. Both drugs were considered broad spectrum in the treatment of epilepsy. 167 patients met the criteria for micro costing analysis. Absolute seizure control was observed in 77.9% of patients treated with LEV and 75.9% of those treated with VPA. The average annual cost per pediatric patient who was nonsyndromatic with monotherapy was $1,749.00 USD. Patients treated with VPA had a direct medical cost of $142,497.00 USD ($58,660.00 USD for clinical studies, $36,405.00 USD for consultation, $26,728.00 USD for hospitalization and $20,704.00 USD for medication), while the use of LEV represented a total direct medical cost of $149,511.00 USD ($63,759.00 USD for clinical studies, $15,499.00 USD in consultations, $31,196.00 USD in hospitalization costs and, $39,057.00 USD for the drug).
Conclusions
Regarding the costs of therapeutic schemes used in the pediatric population with nonsyndromic epilepsy, VPA was the less expensive medication per patient in monotherapy (of difference $18,353.00 USD).
NRBC Concentrations Over Time in Neonates with Moderate to Severe NE with and without Sentinel Events
Authors: weiss Michael , Bliznyuk Nikolay , Rajderkar Dhanashree , Graham Georgia , Sura Livia , Harris Jamie , Wynn James , gaulee pratima
Published: October 2023

Objective: To study the serum concentrations of NRBC over time in neonates with moderate to severe NE.
Study Design: A retrospective cohort study with subjects subdivided into three groups based on definite sentinel events (n=52), probable sentinel events (n=20) and no history of sentinel events (n=63). Peak absolute NRBC concentration and NRBC/100 WBC were compared between groups and compared with MRI Injury score, cord and admission pH/base deficit.
Results: Absolute NRBC concentration peaked at 24.05 hours after birth (CI: 15.30- 32.79), 17.56 hours after birth (CI: 7.35-27.77), and 39.81 hours after birth (CI: 28.73-50.89) in each respective group. The peak in absolute NRBC correlated with the severity of injury in the grey matter in group 2 and white matter in groups 1 and 2. Higher peak absolute NRBC value correlated to a lower admission ABG pH (p<0.05).
Conclusion: NRBC peak at 24 hours after birth in neonates with sentinel events.
Olaparib increases chemosensitivity by upregulating miR-125a-3p in ovarian cancer cells
Authors: Wang Zehua , Pu Tao , Gao Yi , Gao Jianwen , Xu Congjian
Published: October 2023

Objective
Ovarian cancer has the highest mortality rate among malignant gynecological tumors. PolyADP-ribose polymerase (PARP) inhibitor maintenance therapy is the standard treatment. Olaparib is a widely used oral PARP inhibitor for tumors with BRCA mutations, but its effect and molecular mechanism in non-BRCA-mutated tumors remain unclear.
Methods
The antitumor effect of cisplatin alone or in combination with olaparib was analyzed in an ovarian cancer subcutaneous transplantation tumor model in nude mice. miRNA expression was analyzed through an miRNA array and real-time PCR. The effect of miR-125a-3p on proliferation in non-BRCA-mutated A2780 and OVCAR-3 ovarian cancer cells was detected with cell counting kit-8. Changes in cell invasion and migration ability were detected via cell scratch assays and Transwell assays. β-Galactosidase (SA-β-Gal) was used to detect expression changes related to cellular senescence. Cell cycle changes were detected by flow cytometry, and the expression of DNA damage repair proteins was detected by western blotting.
Results
In vivo, cisplatin plus olaparib significantly reduced tumor volume in mice subjected to subcutaneous tumor transplantation (A2780 and OVCAR-3 cells) (p < 0.01) and inhibited tumor growth. Additionally, olaparib induced senescence in A2780 and OVCAR-3 cells by upregulating miRNA-125a-3p. miRNA-125a-3p overexpression significantly inhibited invasion and migration in A2780 and OVCAR-3 cells. The cell cycle was blocked in G0/G1 phase, and the expression of the DNA damage protein gamma-H2AX (γ-H2AX) increased. Transfection of miRNA-125a-3p inhibitors reversed these phenotypes.
Conclusions
Olaparib induces DNA damage and senescence in ovarian cancer cells by upregulating miR-125a-3p expression, improving therapeutic sensitivity.
Efficacy of fentanyl combined with bupivacaine and morphine for cesarean section -- A double-blinded randomized controlled trial
Authors: Li Gehui , Zeng Fanfang , Qi Xiaofei , Tan Xuhong , Wang Hao , Huang Xiaolei , Li Yuantao , Xia Yun
Published: October 2023

Adequate anesthesia is necessary during the cesarean delivery. We studied the anesthesia efficacy and safety of different doses of fentanyl combined with 10 mg bupivacaine and 0.1 mg morphine for elective cesarean section. We performed a double-blinded, randomized, and controlled trial in pregnant women undergoing elective cesarean delivery between April 2019 and June 2021. Eligible women were randomized into groups C, F1, F2, F3, F4, or F5 based on different doses of fentanyl (0, 5, 10, 15, 20, or 25 µg, respectively) during the spinal anesthesia. Each woman also received 0.1 mg morphine and 10 mg bupivacaine. Sensory and motor blocks, muscle relaxation, pain intensity, intraoperative hemodynamics (every 5 min from the intrathecal injection), and adverse events were recorded and compared. Our study included a total of 180 women, with 30 women in each group. Compared with group C, group F2–5 had a faster onset of sensory block (P < 0.001) and group F1–5 had a faster onset of motor block (P = 0.015). During the surgery, diastolic blood pressures in groups F4 and F5 were lower than those in group C between 5 and 20 min after the anesthesia initiation (P < 0.05). Heart rate in group F5 was significantly higher than those in group C at 5 and 15 min after the anesthesia initiation (P = 0.016 and 0.008), respectively. Group F4 and F5 required a higher dose of phenylephrine to prevent hypotension than group C (P = 0.027). There was no significant difference in muscle relaxation, postoperative analgesia, and adverse events among these groups. Intrathecal fentanyl administration at the doses of 10–15µg combined with 10 mg bupivacaine and 0.1 mg morphine could provide rapid and satisfactory analgesia without additional adverse events during elective cesarean delivery.
Geochemical evaluation and the mechanism controlling groundwater chemistry using chemometric approach and groundwater pollution index (GPI) in the Kishangarh city of Rajasthan
Authors: Kumar Manish , Garg Vipin , Kumar Ramesh , Kumar Rajesh
Published: October 2023

Globally, groundwater is a precious natural asset, serving as a dependable source for irrigation and drinking water requirements. This study is primarily focused on delving into the geochemistry of groundwater in the Kishangarh area, located in the Ajmer district of Rajasthan. In pursuit of this goal, the research is divided into three parts within the Kishangarh region: Badgaon Rural (KSGR), Kishangarh Urban (KSGU), and the Kishangarh RIICO marble industrial area (KSGI). Various analytical methods have been executed to assess the suitability of groundwater for various purposes based on pH, electric conductivity, total dissolved solids, hardness, salinity, major anions, and cations. The ionic trend of anions and cations was found as HCO3− >Cl−>SO42−>NO3−>Br−> NO2−>F− and Na+>Ca2+>Mg2+>K+, respectively. Applying statistical techniques such as Principal Component Analysis (PCA) and Pearson Correlation Matrix Analysis (PCMA) makes it evident that the physicochemical attributes of water sourced from the aquifers in the study area result from a blend of diverse origins. In addition, Gibbs, Piper, Durov, and scatter plots assessed groundwater's geochemical evolution. The scatter plots have evaluated the impression of mine acid leachate, evaporitic dissolution, and silicate weathering to upsurge salt formation in the groundwater. The pollution risk evaluation within the study area was conducted using the Groundwater Pollution Index (GPI). This index revealed a notable concern for pollution, particularly in the northern segment of the study region. As a result, it can be inferred that the fine aeolian sand and silt formations in the northern part are relatively more vulnerable to contamination.
A retrospective longitudinal assessment of artificial intelligence- assisted radiographic prediction of lower third molar eruption
Authors: Chopra Shivi , Vranckx Myrthel , Ockerman Anna , Östgren Peter , Krüger-Weiner Carina , Benchimol Daniel , Shujaat Sohaib , Jacobs Reinhilde
Published: October 2023

Prediction of lower third molar eruption is crucial for its timely extraction. Therefore, the primary aim of this study was to investigate the prediction of lower third molar eruption and its uprighting with the assistance of an artificial intelligence (AI) tool. The secondary aim was identifying the incidence of fully erupted lower third molars with hygienic cleansability. In total, 771 patients having two panoramic radiographs were recruited, where the first radiograph was acquired at 8–15 years of age (T1) and the second acquisition was between 16–23 years (T2). The predictive model for third molar eruption could not be obtained as few teeth reached full eruption. However, uprighting model at T2 showed that in cases with sufficient retromolar space, an initial angulation of < 32° predicted uprighting. Full eruption was observed for 13.9% of the teeth, and only 1.7% showed hygienic cleansability. The predictions model of third molar uprighting could act as a valuable aid for guiding a clinician with the decision-making process of extracting third molars which fail to erupt in an upright fashion. In addition, a low incidence of fully erupted molars with hygienic cleansability suggest that a clinician might opt for prophylactic extraction.