bluuebunny/crossref_metadata_2025 huggingface dataset:
Empresas cárnicas en el noroeste de México: Análisis exploratorio en la medición de los sistemas de calidad y desempeño empresarial
Authors: Huerta-Dueñas Michaelene , Sandoval-Godoy Sergio A. , Preciado-Rodríguez Juan Martín
Published: April 2023

Esta investigación tiene por objetivo efectuar un análisis exploratorio acerca de la medición entre la utilización de los sistemas de calidad implementados por distintas empresas cárnicas y su relación con el desempeño empresarial. Se toman como referentes cuatro empresas de un municipio del norte de México, cuyo análisis se apoya en una metodología mixta basada en encuestas estructuradas y cuestionarios-guías de entrevistas a directivos y gerentes. Los resultados ponen de manifiesto, no solo la relevancia del diseño metodológico de medición para ser replicado en otros estudios de caso, sino además, teje coincidencias con otros estudios que concluyen que las empresas con mayor cantidad de sistemas de calidad tienen mejor desempeño en los montos de producción y ventas.
Análisis de riesgo y performance de los fondos de pensión de Intendencias Municipales del Noroeste - RS – Brasil
Authors: Batista Guilherme , Knebel Baggio Daniel , Luís Kelm Martinho , Dalongaro Roberto Carlos
Published: April 2023

Este estudio buscó realizar una revisión de los orígenes de los Fondos de Pensión dentro de un contexto histórico en Brasil. Además, procuró comprender específicamente la composición de los Fondos de Pensión Municipal de cuatro Intendencias de la Región Noroeste del Estado de Rio Grande do Sul, con el objetivo de describir y analizar el proceso de gestión de los activos de los Fondos de Pensión de las Intendencias estudiadas. Para esto, se utilizó como metodología de análisis, el Índice de Sharpe, CAPM así como el cálculo del BETA. En resumen, se observó que el gestor de los Fondos de Pensión analizados ha desempeñado un buen trabajo, ya que los resultados de sus actuaciones fueron generalmente por encima de las aplicaciones relativas a los CDBs, utilizados como indicador libre de riesgo.
La gestión del cambio como implicación subjetiva de los líderes y los colaboradores
Authors: Cornejo Hernán
Published: April 2023

El presente trabajo integra una investigación que se efectúa en el ámbito de la Universidad Abierta Interamericana, denominada “Gestión del cambio empresarial en el contexto manufacturero pyme de la ciudad de Rosario”.El objetivo de este trabajo es colaborar en el desarrollo de competencias ejecutivas y gerenciales en dicho sector de la economía, que posibiliten el dinámico proceso de comprensión, interpretación y acción en la gestión, de la realidad de los contextos de inserción y de los sujetos implicados en la misma.La metodología utilizada es cualitativa a partir de entrevistas en profundidad con titulares y gerentes de empresas.En las conclusiones se asume la especificidad de la práctica compleja de la gestión del cambio en dichas organizaciones.
Un modelo econométrico para determinar el valor de venta de proyectos inmobiliarios en la ciudad de Santiago
Authors: Rowland López Fernando
Published: April 2023

La ciudad de Santiago se encuentra ubicada en la Región Metropolitana de Santiago, es la capital de la República de Chile y habitan en ella 6.257.516 habitantes. No existe un estudio acabado que muestre cuales son las principales variables que inciden en el valor de venta final de los proyectos inmobiliarios de la ciudad de Santiago. Por ello, utilizando un modelo de regresión lineal con una base de datos de 552 proyectos inmobiliarios en un rango de 14 años, determinamos qué variables son las que más influyen en el valor final de un proyecto inmobiliario en Santiago. Encontramos que las variables más influyentes en el precio final son el precio del terreno, costo de construcción y otros gastos inmobiliarios.
Inclusión financiera en estudiantes universitarios de pregrado
Authors: Cárdenas Riffo Álvaro , Montaña Ampuero Virginia , Ferrada Bórquez Luz María
Published: April 2023

La investigación tiene por objetivo analizar la inclusión financiera en estudiantes de pregrado en una universidad pública y regional. La información proviene desde la demanda, a través de un cuestionario diseñado para este propósito. Se estiman indicadores de acceso, uso y barreras a los productos financieros, así como un indicador agregado de inclusión. Mediante Mínimos Cuadrados Ordinarios (MCO), se genera un modelo que identifican factores explicativos del indicador agregado. Se concluye que los estudiantes poseen una tasa alta de inclusión financiera, sin embargo, se sitúan en un nivel preferentemente básicos. Asimismo, ser mujer, tener mayor ingreso personal, estar en cursos más avanzados, y estar formándose en área de la ciencias administrativas y económicas, influye positiva y significativamente en la inclusión.
Estrategias genéricas de desarrollo regional en la cadena de suministros de la industria del plástico
Authors: Vega M. Alejandro , Benítez G. Juan , Yévenes S. Ariel
Published: April 2023

El presente artículo, comprende un análisis estratégico de la industria del plástico nacional y regional, indagando en las estrategias que podrían implementarse para el potenciamiento en el caso de la región del Bío-Bío.El artículo se estructura en tres ámbitos. Un primer ámbito, hace un completo diagnóstico de la industria del plástico nacional y regional donde, para el marco regional, muestra un análisis estratégico que permite esbozar lineamientos para el desarrollo de esta industria.En un segundo ámbito, se hace una breve descripción de la estructura de la cadena de suministros del plástico en la VIII región y una descripción de la industria petroquímica, indagando en las formas de agregar valor a la industria y un análisis de mercado para identificar cuales son las inversiones más urgentes, en base a las mayores debilidades de la producción regional de la industria del plástico.El tercer ámbito, muestra un análisis comparativo, el que permite definir cuales podrían ser emplazamientos con potencialidades para la instalación de un parque tecnológico e industrial del plástico, y además un estudio empírico de la competitividad de la industria del plástico en la región del Bío-Bío.En su conjunto, lo analizado permite levantar estrategias orientadas a maximizar inversiones, crecer como industria y dominar los nichos de mercado que presenta nuestro país y Sudamérica.
Distribución de ingresos y determinación de tarifas
Authors: Viera Castillo Daniel
Published: April 2023

El presente trabajo pretende demostrar que es posible obtener tarifas que incorporen la distribución del ingreso y que simultáneamente sean eficientes.Es un trabajo que se sustenta en los fundamentos teóricos de la microeconomía y de la economía del bienestar y de las restricciones que presenta fijar precios basados en costos marginales.El modelo que se aplica sugiere que el precio que debe establecer una empresa de Servicios Públicos, ya sea Privada o Pública, es un precio que atienda hasta cierto punto sus efectos sobre la distribución del ingreso, como también los efectos en la asignación de recursos, introduciendo ciertos juicios de valor explícitos.
Cuantificación del impacto de los procesos de negocio y de tecnologías de información, sobre las metas de utilidad
Authors: Bravo Silva Sergio
Published: April 2023

Se propone un modelo y método para cuantificar el impacto de los procesos operacionales críticos de un negocio y de los procesos de tecnologías de información y comunicación, sobre la meta de utilidad de la empresa. Se considera tanto el impacto positivo a la utilidad, como el negativo, derivado de riesgos de fallas en procesos. Para este propósito, definimos un dominio de procesos operacionales críticos de negocios y otro dominio de procesos de tecnologías de información y comunicación.Los dominios se representan por árboles invertidos, cada uno de varios niveles. El nivel inferior contiene procesos elementales, y los superiores, agrupaciones de ellos. A cada proceso o grupo hemos asociado las siguientes variables: Importancia relativa, contribución esperada, riesgos e impactos negativos.La matriz de cruce de los procesos de más bajo nivel, de ambos dominios, configura un espacio de interacción, en el cual se hace presente la variable dependencia, cuyo valor expresa el grado en que un proceso de negocio depende del proceso TIC que le cruza. La dependencia provoca transferencias de valores entre variables de procesos de negocio y procesos TIC. El cálculo de los nuevos valores y su consolidación hacia niveles superiores, determina la contribución e impacto negativo de cada proceso y grupo de ellos sobre las metas de utilidad de la empresa.El modelo y método son de utilidad al momento de planificar, permitiendo simular contribuciones e impactos de procesos, para diferentes valores planificados de las variables(nuevos metas,pesos,riesgos y dependencias). La comparación de los impactos del plan con los de períodos anteriores, ayuda a evaluar el plan.Por otra parte, en momento de control, se facilita la comparación de cifras del plan inicial con las logradas y decidir ajustes para un nuevo período.
Validación de un instrumento de medición de la calidad del servicio bancario en internet. Un análisis aplicado a la ciudad de Arica
Authors: Viera Castillo Daniel , Hicil M. Raúl , Orozco V. Álvaro
Published: April 2023

La calidad del servicio se ha convertido en uno de los conceptos empresariales más importantes de los últimos tiempos. A pesar de haber varios factores a la hora de nombrar elementos claves en la estrategia empresarial, tales como la imagen o el producto, la calidad del servicio se ha posicionado por sobre ellos por ser un elemento diferenciador de mucha importancia entre las empresas. Para la banca, la diferenciación se ha vuelto una necesidad, y la calidad del servicio puede ser la mayor herramienta para este objetivo. Es por ello que su medición se vuelve crucial para los directivos bancarios. Basándose en diversos estudios sobre la calidad del servicio, esta investigación trata de desarrollar un instrumento que permita a los directivos poder medir de manera confiable la calidad del servicio de la banca por Internet y lograr tomar decisiones que permitan una diferenciación de sus servicios en línea. La investigación también discute los problemas en el desarrollo del instrumento y termina con las conclusiones del mismo, no sin antes haber señalado ciertos alcances pertinentes al estudio.
La distancia cultural y el riesgo país ¿cómo influyen en la inversión directa en el extranjero?
Authors: Almodóvar Martínez Paloma , Navas López José Emilio , Huerta Riveros Patricia
Published: April 2023

Este trabajo pretende estudiar la influencia que tiene la distancia cultural y el riesgo país en la decisión sobre la modalidad de entrada de la empresa, para ello se realiza una revisión de los trabajos empíricos desarrollados hasta el momento. Se procede a la revisión de los diferentes conceptos que aluden a la distancia cultural hasta llegar a una definición integradora. De igual manera, se delimita el compendio de variables que integran la distancia cultural para identificar las variables que deberá controlar la empresa en su proceso de internacionalización. Finalmente presentamos los estudios realizados que defienden diferentes correlaciones entre la distancia cultural y la modalidad de entrada para presentar un enfoque integrador que utiliza la variable riesgo país como moderadora de la decisión final adoptada por la empresa.
Calidad del servicio en la modernización del Estado
Authors: Acuña Hormazábal Álvaro José , Salazar Botello Carlos Mauricio
Published: April 2023

García y Dolan (1997) señalan que para modificar las conductas de las personas de las organizaciones, más que modificar actitudes, lo que hay que hacer es modificar las creencias. El presente trabajo realiza un estudio comparativo de las creencias organizacionales en torno a la calidad del servicio entre las unidades de emergencia de los centros de salud familiar de la ciudad de Chillán y la unidad de emergencia de un hospital tipo uno de la misma comuna, con el propósito de identificar si existe la evolución esperada en la calidad con la que se entrega el servicio, acorde a los lineamientos establecidos por las diferentes iniciativas de la reforma y modernización del Estado de Chile.Para obtener los datos se creó y aplicó un cuestionario con una escala tipo likert de cinco puntos, el cuestionario de creencias organizacionales de calidad del servicio se dividió en cuatro dimensiones. Se realizó la tabulación y el análisis de 293 cuestionarios y sus resultados muestran una evolución positiva en las creencias en torno a la calidad del servicio de los centros de salud familiar, principalmente en la dimensión empatía.
Estudio empírico de calidad de vida laboral, cuatro indicadores: Satisfacción laboral, condiciones y medioambiente del trabajo, organización e indicador global, sectores privado y público. Desarrollo, aplicación y validación del instrumento
Authors: Chiang Vega Dra. María Margarita , Krausse Martínez Karina Ayres
Published: April 2023

La investigación tiene por objeto elaborar un instrumento para conocer la calidad de vida laboral de la empresa. La muestra de este estudio corresponde a 128 trabajadores de los sectores privado y público.El instrumento de medición aplicado para la calidad de vida laboral consta de 118 ítems divididos en 4 indicadores: satisfacción laboral, condiciones y medioambiente del trabajo, organización e indicadores globales.Se puede concluir que las escalas, están validadas para esta muestra y pueden ser utilizadas para medir la calidad de vida laboral de empresas privadas y de instituciones estatales y con ello ayudar a mejorar y corregir las estrategias con que operan las empresas u organizaciones tanto a sus grupos de interés internos como externos (stakeholders). AbstractThis research intends to elaborate an instrument to know the quality of labor life of the company. The sample of this study corresponds to 128 workers from private and public sectors.The measuring instrument applied for the quality of labor life consists of 118 items divided in 4 indicators: labor satisfaction, conditions and global environment of the work, organization and indicators.It is possible to be concluded that the scales, are validated for this sample and can be used to measure the quality of labor life of private companies and state institutions and with it to help to improve and to correct the strategies whereupon they as much operate the companies or organizations to its internal groups of interest and external (stakeholders) as well.
Diálogos entre as intervenções assistidas por animais (IAA’s) e a psicopatologia fenomenológica: possibilidades clínicas de intervenção em psicologia
Authors: Verônica Collares da Silva Lidiane
Published: April 2023

A presente obra tem por objetivo principal apresentar contribuições das Intervenções Assistidas por Animais para a compreensão dos fenômenos psicopatológicos. Influenciado pela Fenomenologia de Edmund Husserl, o psiquiatra e filósofo alemão Karl Jaspers desenvolveu uma psicopatologia que tem como principal característica a compreensão da história de vida do paciente e a sua forma de estabelecer relações com o outro e com o mundo, ao invés de somente explicar a realidade objetiva. Na segunda metade do século XX, a psiquiatra brasileira Nise da Silveira e o psiquiatra norte-americano Boris Levinson consolidaram as Intervenções Assistidas por Animais como terapêutica eficaz para o acompanhamento de pacientes com transtornos psicológicos. Nessa perspectiva, este trabalho pretende primeiramente descrever o histórico do convívio do homem com animais de estimação, em seguida apresentar os possíveis benefícios descritos nas produções científicas sobre as Intervenções Assistidas por Animais para a saúde existencial e evidenciar as contribuições da Psicopatologia Compreensiva de Karl Jaspers e da Fenomenologia de Edmund Husserl para a Psicologia Clínica.
DE TAYLOR A GUERREIRO RAMOS: UMA JORNADA PELO PROCESSO EVOLUTIVO DAS PRINCIPAIS TEORIAS DA ADMINISTRAÇÃO
Authors: Moura Alexandro Avila de , Costa Danilo De Melo
Published: April 2023

Este trabalho revisita as principais teorias de administração, do Taylorismo até a Teoria Crítica da Administração, a partir de obras clássicas sobre o tema. O objetivo desta jornada, além de apresentar as principais características de cada teoria, é procurar por relações entre teorias predecessoras e sucessoras e evidenciar o processo de evolução delas. Esta jornada está estruturada em cinco tópicos: teorias de Administração Científica, Clássica e Burocrática; teorias das Relações Humanas e Comportamental; teorias Estruturalista e Geral dos Sistemas; teoria Contingencial e teoria Crítica da Administração. Para discutir as teorias de Administração Científica, Clássica e Burocrática são analisados os trabalhos de Weber, Taylor e Fayol. Nas teorias das Relações Humanas e Comportamental os autores abordados foram Homans e Cruz Junior. Para as teorias Estruturalista e Geral dos Sistemas trabalhou-se com Motta e Pizza Junior. Já na Teoria Contingencial os autores analisados foram Chandler, Lodi e Donaldson. Para finalizar na Teoria Crítica da Administração trabalhou-se com Tragtenberg e Guerreiro Ramos. Além de relacionar uma série de evidências do processo de evolução das teorias de administração, este trabalho propõe relações entre a Paradigma Paraeconômico de Guerreiro Ramos, Teoria Contingencial e outras teorias que a antecederam.
Health Care Provider Prescribing Habits and Barriers to Use of New Type 2 Diabetes Medications: A Single-System Survey Study
Authors: Yaseen Aseel , Lahiri Sharon W.
Published: April 2023

This survey study evaluated type 2 diabetes medication prescribing patterns of health care providers in different specialties and of different professional designations or levels of training at an academic health care system and sought to identify factors influencing medication choices and uncover barriers to prescribing glucagon-like peptide 1 receptor agonists and sodium–glucose cotransporter 2 inhibitors. High cost and the need for prior authorizations were reported as the main barriers to prescribing drugs in these two classes, along with a lack of experience among some specialists. Greater system support to decrease the administrative burden of prescribing newer medications and greater dialogue among the specialties caring for patients with cardiorenal comorbidities can improve prescribing of these drugs in accordance with clinical practice recommendations.
Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway
Authors: Dong Lijie , Cheng Rui , Ma Xiang , Liang Wentao , Hong Yaru , Li Hui , Zhou Kelu , Du Yanhong , Takahashi Yusuke , Zhang Xiaomin , Li Xiao-rong , Ma Jian-xing
Published: April 2023

Monocyte activation plays an important role in diabetic complications such as diabetic retinopathy (DR). However, the regulation of monocyte activation in diabetes remains elusive. Fenofibrate, an agonist of peroxisome proliferator-activated receptor-α (PPARα), has shown robust therapeutic effects on DR in patients with type 2 diabetes. Here we found that PPARα levels were significantly downregulated in monocytes from patients with diabetes and animal models, correlating with monocyte activation. Fenofibrate attenuated monocyte activation in diabetes, while PPARα knockout alone induced monocyte activation. Furthermore, monocyte-specific PPARα overexpression ameliorated, while monocyte-specific PPARα knockout aggravated monocyte activation in diabetes. PPARα knockout impaired mitochondrial function while also increasing glycolysis in monocytes. PPARα knockout increased cytosolic mitochondrial DNA release and activation of the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway in monocytes under diabetic conditions. STING knockout or STING inhibitor attenuated monocyte activation induced by diabetes or by PPARα knockout. These observations suggest that PPARα negatively regulates monocyte activation through metabolic reprogramming and interaction with the cGAS-STING pathway.
Comparison of Novel Wide-Field In Vivo Corneal Confocal Microscopy With Skin Biopsy for Assessing Peripheral Neuropathy in Type 2 Diabetes
Authors: Badian Reza A. , Ekman Linnéa , Pripp Are Hugo , Utheim Tor Paaske , Englund Elisabet , Dahlin Lars B. , Rolandsson Olov , Lagali Neil
Published: April 2023

Diabetic peripheral neuropathy (DPN) is a serious complication of diabetes, where skin biopsy assessing intraepidermal nerve fiber density (IENFD) plays an important diagnostic role. In vivo confocal microscopy (IVCM) of the corneal subbasal nerve plexus has been proposed as a noninvasive diagnostic modality for DPN. Direct comparisons of skin biopsy and IVCM in controlled cohorts are lacking, as IVCM relies on subjective selection of images depicting only 0.2% of the nerve plexus. We compared these diagnostic modalities in a fixed-age cohort of 41 participants with type 2 diabetes and 36 healthy participants using machine algorithms to create wide-field image mosaics and quantify nerves in an area 37 times the size of prior studies to avoid human bias. In the same participants, and at the same time point, no correlation between IENFD and corneal nerve density was found. Corneal nerve density did not correlate with clinical measures of DPN, including neuropathy symptom and disability scores, nerve conduction studies, or quantitative sensory tests. Our findings indicate that corneal and intraepidermal nerves likely mirror different aspects of nerve degeneration, where only intraepidermal nerves appear to reflect the clinical status of DPN, suggesting that scrutiny is warranted concerning methodologies of studies using corneal nerves to assess DPN.

Article Highlights

Comparison of intraepidermal nerve fiber density with automated wide-field corneal nerve fiber density in participants with type 2 diabetes revealed no correlation between these parameters. Intraepidermal and corneal nerve fibers both detected neurodegeneration in type 2 diabetes, but only intraepidermal nerve fibers were associated with clinical measures of diabetic peripheral neuropathy. A lack of association of corneal nerves with peripheral neuropathy measures suggests that corneal nerve fibers may be a poor biomarker for diabetic peripheral neuropathy.
Higher Sensory Cortical Energy Metabolism in Painful Diabetic Neuropathy: Evidence From a Cerebral Magnetic Resonance Spectroscopy Study
Authors: Sloan Gordon , Anton Adriana , Caunt Sharon , Wilkinson Iain , Selvarajah Dinesh , Tesfaye Solomon
Published: April 2023

Alterations in the resting-state functional connectivity and hyperperfusion of pain processing areas of the brain have been demonstrated in painful diabetic peripheral neuropathy (DPN). However, the mechanisms underlying these abnormalities are poorly understood; thus there is good rationale to explore whether there is higher energy consumption in the pain processing areas of the brain. We performed a 31P magnetic resonance spectroscopy study to explore cellular energy usage (bioenergetics) in the primary somatosensory (S1) cortex in a well-characterized cohort of participants with painful and painless DPN. S1 phosphocreatine (PCr):ATP, a measure of energy consumption, was significantly reduced in painful compared with painless DPN. This is indicative of greater S1 cortical energy consumption in painful DPN. Furthermore, S1 PCr:ATP correlated with pain intensity during the MRI. S1 PCr:ATP was also significantly lower in painful-DPN individuals with moderate/severe pain compared with those with low pain. To our knowledge, this is the first study to demonstrate higher S1 cortical energy metabolism in painful compared with painless DPN. Moreover, the relationship between PCr:ATP and neuropathic pain measures shows that S1 bioenergetics is related to the severity of neuropathic pain. S1 cortical energetics may represent a biomarker of painful DPN and could have the potential to serve as a target for therapeutic interventions.

Article Highlights

Energy consumption within the primary somatosensory cortex appears to be greater in painful compared with painless diabetic peripheral neuropathy. The measure of energy metabolism, PCr:ATP, within the somatosensory cortex correlated with pain intensity and was lower in those with moderate/severe compared with low pain. To our knowledge. this is the first study to indicate higher cortical energy metabolism in painful compared with painless diabetic peripheral neuropathy, and thus has the potential to act as a biomarker for clinical pain trials.
Risk of Type 1 Diabetes in Children Is Not Increased After SARS-CoV-2 Infection: A Nationwide Prospective Study in Denmark
Authors: Noorzae Rohina , Junker Thor Grønborg , Hviid Anders Peter , Wohlfahrt Jan , Olsen Sjurdur Frodi
Published: April 2023

OBJECTIVE

It has been hypothesized that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children can increase risk of developing type 1 diabetes.

RESEARCH DESIGN AND METHODS

We undertook a prospective, register-based analysis of children in Denmark by investigating the association between SARS-CoV-2 infection and subsequent risk of type 1 diabetes. During the pandemic, Denmark had one of the highest test rates per capita in the world, and 90% of all Danish children were tested.

RESULTS

Compared with children with a history of only negative SARS-CoV-2 tests, we did not observe a higher risk of first-time diagnosis of type 1 diabetes in children 30 days or more after a positive SARS-CoV-2 test (hazard ratio 0.85; 95% CI 0.70–1.04).

CONCLUSIONS

Our data do not support that SARS-CoV-2 infection is associated with type 1 diabetes or that type 1 diabetes should be a special focus after a SARS-CoV-2 infection in children.
What Does a New Health Technology Landscape Mean for Hispanic/Latino People With Diabetes?
Authors: Rodriguez Jorge A. , Seiglie Jacqueline Anne , Caballero Augusto Enrique
Published: April 2023

  

Despite advances in type 2 diabetes management, disparities persist among Latinos living in the United States. Latinos, the fastest-growing ethnic minority population in the United States, are twice as likely to have diabetes-related complications and 1.3 times more likely to die from diabetes than non-Latino Whites (1). These inequities are driven by a complex interplay of biological, social, structural, and health system factors, including difficulty navigating the health care system (2,3). For example, Latinos have higher no-show rates to clinic visits and have lower rates of medication adherence than non-Latino Whites (4,5). These persistent disparities demand innovation. 
Higher sensory cortical energy metabolism in Painful-Diabetic Neuropathy: evidence from a cerebral Magnetic Resonance Spectroscopy study
Authors: Sloan Gordon , Anton Adriana , Caunt Sharon , Wilkinson Iain , Selvarajah Dinesh , Tesfaye Solomon
Published: April 2023

  

Alterations in the resting state functional connectivity and hyperperfusion of pain processing areas of the brain have been demonstrated in painful-Diabetic Peripheral Neuropathy (DPN). However, the mechanisms underlying these abnormalities are poorly understood. There is thus a good rationale to explore if there is higher energy consumption in the pain processing areas of the brain.

We performed a 31Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) study to explore cellular energy usage (bioenergetics) in the primary somatosensory (S1) cortex in a well-characterised cohort of participants with painful- and painless-DPN. 

S1 PCr:ATP, a measure of energy consumption, was significantly reduced in painful- compared with painless-DPN. This is indicative of greater S1 cortical energy consumption in painful-DPN. Furthermore, S1 PCr:ATP correlated with pain intensity during the MRI. S1 PCr:ATP was also significantly lower in painful-DPN individuals with moderate/severe pain compared to those with low pain.

This is the first study to demonstrate higher S1 cortical energy metabolism in painful- compared with painless-DPN. Moreover, the relationship between PCr:ATP and neuropathic pain measures shows that S1 bioenergetics is related to the severity of neuropathic pain. S1 cortical energetics may represent a biomarker of painful-DPN and could have the potential to serve as a target for therapeutic interventions.
Dysregulation of CXCL1 expression and neutrophil recruitment in insulin resistance and diabetes-related periodontitis in male mice
Authors: Shinjo Takanori , Onizuka Satoru , Zaitsu Yumi , Ishikado Atsushi , Park Kyoungmin , Li Qian , Yokomizo Hisashi , Zeze Tatsuro , Sato Kohei , St-Louis Ronald , Fu Jialin , I-Hsien Wu , Mizutani Koji , Hasturk Hatice , E Van Dyke Thomas , Nishimura Fusanori , L King George
Published: April 2023

  

Insulin resistance and hyperglycemia are risk factors for periodontitis and poor wound healing in diabetes, which have been associated with selective loss of insulin- activation of the PI3K/Akt pathway in the gingiva. This study showed that insulin resistance in the mouse gingiva due to selective deletion of smooth muscle and fibroblast insulin receptor (SMIRKO mice) or systemic metabolic changes induced by high fat diet (HFD) in HFD-fed mice exacerbated periodontitis-induced alveolar bone loss, preceded by delayed neutrophil and monocyte recruitment and impaired bacterial clearance compared to their respective controls. The immunocytokines, CXCL1, CXCL2, MCP-1, TNFα, IL-1β and IL-17A exhibited delayed maximal expression in the gingiva of male SMIRKO and HFD-fed mice compared to controls. Targeted overexpression of CXCL1 in the gingiva by adenovirus normalized neutrophil and monocyte recruitment and prevented bone loss in both mouse models of insulin resistance. Mechanistically, insulin enhanced bacterial lipopolysaccharide-induced CXCL1 production in mouse and human gingival fibroblasts (GFs), via Akt pathway and NF-κB activation, which were reduced in GFs from SMIRKO and HFD-fed mice. These results provided the first report that insulin signaling can enhance endotoxin induced CXCL1 expression to modulate neutrophil recruitment, suggesting CXCL1 as a new therapeutic direction for periodontitis or wound healing in diabetes. 
UM OLHAR PARA AS PRODUÇÕES QUE ABORDAM OS PRINCÍPIOS DA ANDRAGOGIA NA EDUCAÇÃO DE JOVENS E ADULTOS
Authors: Rosa Ribeiro Renata Deli da , Muenchen Cristiane
Published: April 2023

A presente pesquisa apresenta um estudo bibliográfico realizado nos portais de teses e dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e da Biblioteca Digital de Teses e Dissertações (BDTD), realizado no período de 2007 a 2021, sobre as produções acadêmicas que abordam os pressupostos teóricos Freireanos, Ciência-Tecnologia-Sociedade (CTS) e Andragogia. O estudo emergiu da necessidade de compreender o que estava sendo produzido na academia relacionado à Andragogia articulado aos princípios teóricos de Freire, CTS e Abordagem Temática na Educação de Jovens e Adultos (EJA). Para a análise do corpus da pesquisa, utilizou-se a metodologia da Análise Textual Discursiva (MORAES; GALIAZZI, 2016) a partir da discussão de categorias à priori. Nos resultados encontrados, observou-se a utilização da teoria andragogia no cenário acadêmico em processos de ensino e aprendizagem de alguns cursos de graduações, tendo uma maior representatividade em cursos do âmbito educacional.
Komitmen Organisasional Karyawan Indomaret Di Bojonegoro ditinjau dari Keadilan Organisasional, Kepuasan Kerja dan Trust
Authors: Umayatin Sri , Agustina Tri Siwi
Published: April 2023

Komitmen organisasional menjadi isu yang penting ditingkatkan bagi sebuah perusahaan. Tingkat komitmen organisasional dapat mempengaruhi seberapa besar niat karyawan untuk tetap bertahan di organisasi tersebut. Penelitian ini bertujuan untuk menguji pengaruh keadilan yang dirasakan karyawan serta kepuasan bekerja di organisasi yang akan berdampak pada keinginan bertahan pada organisasi tersebut. Penelitian ini juga menguji trust sebagai variabel moderasi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei, menggunakan data primer dari 79 karyawan dimana data didapatkan dengan menggunakan kuesioner yang dibagikan kepada karyawan PT. Indomarco Prismatama (Indomaret) di Bojonegoro. Prosedur pengambilan sampel dilakukan dengan metode purposive sampling, pada karyawan Indomaret wilayah Bojonegoro dan posisi bukan sebagai kepala toko. Penelitian menggunakan perangkat lunak Smart PLS 3.0 untuk mempermudah teknik analisa data. Hasil penelitian ini menunjukkan bahwa keadilan organisasional berpengaruh secara positif dan signifikan terhadap komitmen organisasional, kepuasan kerja berpengaruh secara positif signifikan terhadap komitmen organisasional. Trust sebagai moderasi tidak memoderasi pengaruh keadilan organisasional terhadap komitmen organisasional, begitu pula Trust juga tidak memoderasi pengaruh kepuasan kerja terhadap komitmen organisasional
The Crucial History of Sharia Banking Law Development in Indonesia
Authors: Dahlan Ahmad , Mawardi Mawardi , Mahfudz Shaifurrokhman
Published: April 2023

This article aims to explain Sharia banking law development in Indonesia from various sources based on facts or documents found in literatures and interviews made with several informants involved in the process of formulating Sharia banking law development as well as all law and legislation aspects in Indonesia. Two well-known figures, Karnaen A. Perwaatmadja and M. Syafi'i Antonio, were involved in the process of formulating Sharia banking law development in 1990s, as well as Zuhrizal Zubir, Sharia Bank Supervisor from Bank Indonesia Jakarta, and Bank Indonesia Purwokerto, Central Java in 2002. The research results showed that Sharia banking law development in Indonesia historically had several stages. First, the formulation of Sharia banking law was full of political contents. Second, Sharia banking law was based on a dual banking system dominantly in market accommodation. Third, the independence of legalization of Sharia banking law did not increase Sharia banking market share.
Determination of liability in criminal proceedings: current state
Authors: Muzychenko O. , Karandas M.
Published: April 2023

The article is devoted to the investigation of the prosecutor's change of responsibility in criminal proceedings and the problems that arise when the prosecutor uses the specified institute. Attention was drawn to the increase in the number of law enforcement agencies with investigative functions, which increased the relevance of the highlighted issue. The judicial decision on the change of jurisdiction in criminal proceedings has been analyzed. The main positions of the Criminal Court of Cassation as part of the Supreme Court regarding the determination of the jurisdiction of the State Bureau of Investigation, the National Anti-Corruption Bureau of Ukraine, the Security Service of Ukraine and the National Police of Ukraine are highlighted. Attention is focused on the decision of the Joint Chamber of the Criminal Court of Cassation as part of the Supreme Court, which defines clear criteria for recognizing the pre-trial investigation as effective. In addition, the approaches proposed by scientists regarding the application of the norms of the criminal procedural law, which regulate the institution of criminal proceedings, are summarized, and the expediency of including in the list of decisions of the investigating judge, which can be challenged during the pre-trial investigation, the decision of the investigating judge on the refusal to satisfy the complaint against the prosecutor's decision on determination of liability. The range of problems that occur when the jurisdiction of a criminal proceeding is changed and the consequences of a change of jurisdiction by the prosecutor on the body of a pre-trial investigation, which, according to Article 216 of the Criminal Procedure Code of Ukraine, is not authorized to conduct a pre-trial investigation, for example, abuse by the prosecutor of his right to change jurisdiction with from one body of pre-trial investigation to another. The importance of proper substantiation by the prosecutor of the resolution on changing jurisdiction, as well as the introduction of judicial control over the legality of the prosecutor's determination of jurisdiction for a specific body of pre-trial investigation, is highlighted.
Legal regulation of electronic evidence and the practice of their use in the judiciary of Ukraine
Authors: Akhtyrska N.
Published: April 2023

The article, based on the analysis of judicial practice (criminal, civil, administrative and economic proceedings), analyzes the assessment and use of evidence received in electronic form by courts, and draws a conclusion regarding the lack of unanimity in these issues; in particular, regarding the very concept of "electronic evidence" (in the Criminal Procedural Code of Ukraine, unlike other procedural codes, this term is not defined) and its duplicate or copy, the method of recording and certification (by whom: by the provider or another entity), the use screenshot seizure, etc. Ukraine's signing on November 30, 2022 of the Second Additional Protocol to the Convention on Cybercrime, which is aimed at improving the process of electronic data collection, marks the beginning of a new law-making process to improve Ukraine's national legislation in accordance with international standards. The basis for this is the created legal basis for international direct cooperation with service providers, accelerated forms of cooperation for disclosure of information about the subscriber and traffic data, accelerated cooperation and disclosure of information in emergency situations, additional tools for mutual assistance, data protection and other guarantees of the rule of law are also provided , the definition of "emergency situation" is given for the first time, which should be understood as a situation that creates a significant and unavoidable risk to the life or safety of any natural person, and "personal data" is considered to be information related to the identification of a person. On the basis of updated international standards, current legislation and practice, it is proposed to start an in-depth study of the "Theory of electronic evidence", which will contribute to the development of verified bills and the adoption by the parliament of a law that would specify the unambiguous terms "electronic evidence", a copy/duplicate of electronic evidence, the order of withdrawal, records or certificates, the provider's authority to assist in legal proceedings.
General theoretical analysis of legal security of business activity
Authors: Kovalenko І.
Published: April 2023

Effective legal means of regulating relations between business entities and preventing violations of the latter's rights and interests protected by law include compliance by the participants of business relations, including business entities, state authorities, etc., with the requirements of current legislation. That is, such a legal regime is desirable, within which the best way to protect the rights of business entities is to prevent violations of the rights of these entities and, as a result, the absence of the very need to renew rights.

It is clear that such a preventive influence on the behavior of business entities is the result not only of the conscientious behavior of the participants in economic relations, but, most likely, the consequence of the regulatory influence on the behavior of these entities of the norms of current legislation, which contains binding, prohibitive and other legal prescriptions (requirements), the existence of which is aimed at preventing violations of the rights and legally protected interests of business entities and restoring these rights and interests in cases of their violation, non-recognition or dispute.

The need to protect subjective rights and interests arises primarily in connection with illegal behavior. However, protection can also take place in the event of a threat of violation of the right in the future, which may not always be considered illegal behavior.

The threat may arise due to the actions of the right holder himself, for example, in connection with the loss of the corresponding document. Defense is also allowed in case of violation of interest by non-illegal behavior. A person can apply to the court for protection in the event of a conflict between his interests and the interests of other participants in the legal relationship, and even when the behavior of each of them is lawful.

The subject of research in the article is specific norms of constitutional, civil, economic and administrative law, which establish legal guarantees of ensuring and protecting entrepreneurial activity by the norms of national law.
Specific practice of application of the criminal law provisions establishing liability for bribery of an employee of an enterprise institution or organization
Authors: Turlova Yu
Published: April 2023

The article, resting upon the data of official statistics, examines the practice of application of the criminal law provisions which establish liability for bribing an employee of an enterprise, institution, or organization.Quantitative indicators of this crime category are calculated, particularly, their rate (336 crimes) and the av- erage annual number (34 crimes). The main trends and periods of reproduction of the crimes under study are determined: the first period (2013–2019) is characterized by a stable upward trend from the minimum initial number of 16 crimes (2013) to the maximum number of 67 crimes (2019); the second period (2020–2022) is notable for a sharply decreased number of recorded crimes and a relative stabilization of the relevant indica- tors at the level of average numbers for the whole period under study.The practical application of Part 5 of Art. 354 of the Criminal Code of Ukraine, which describes one of the special releases of a person from criminal liability provided for in the Criminal Code, is an isolated instance and has no noticeable anti-corruption influence on the area of legal relations under study.The article determines the main quantitative indicators which reflect the imposition of criminal liability and punishment on the persons who offer an illegal benefit, as well as on those who receive it. Their ratio is 30% to 70%, respectively. The author arrives at the conclusion about defectiveness of the construction of the sanctions established under Parts 1–4 of Art. 354 of the Criminal Code of Ukraine and suggests that their optionality be limited to three main types of punishments, and this is reasoned, in particular, by the specifics of the actual criminalization of the crime under study. The author established that a fine was the predominant type of punishment (90% of those convicted). It is noted that release from punishment was very rarely (3.4%) applied to those convicted under Art. 354 of the Criminal Code of Ukraine, and this makes this category of cases significantly different from others which have the corresponding share reaching a half of the total number of convicts.Given the social and role characteristics of the convicts most of whom are engaged in the fields of med- icine and education, the author suggests that deprivation of the right to hold certain positions or practice certain professions be included in the sanctions under the relevant provisions as an additional punishment.
Online mediation: international experience and prospects for implementation in Ukraine
Authors: Bondarchuk N. , Radchenko O.
Published: April 2023

The article discusses the problems of online mediation in Ukraine. The article analyzes the legislative regulation of mediation. As well as the use of online methods for the lawsuits resolution, which can significantly reduce the burden on the judicial system and ensure access to justice for all citizens under martial law and pandemic conditions (COVID-19). In the context of the pandemic, the introduction of online mediation becomes especially relevant, as it aims not only to simplify the process of lawsuits resolution, but also to ensure the preservation of citizens’ health. «The guidelines for preparing and conducting online mediation" adopted by the CA "NAMU" were analyzed. Created by the professional community of mediators as a response to the challenges that arise in the daily legal professional activities of mediators, such as: new circumstances, lack of legislation, etc. And distributed in order to provide support for safe professional practice. Determined the main factors of the prospects for the rapid development of alternative lawsuits resolution methods under digitalization and martial law in Ukraine.

An analysis of the international legal regulation of online mediation has been carried out. It has been researched that the European legal system is aimed at encouraging the parties in lawsuits to use proper legal procedures to resolve the legal dispute, but not only in court. An analysis of the challenges of online mediation, which the mediator and participants face when conducting mediation in this format, has been carried out, as well as the advantages and disadvantages of online mediation in Ukraine have been determined. The ethical principles for online lawsuits resolution are set to find a wider audience as stakeholders in ODR systems become more expansive and inclusive. Different ways to improve the legislative regulation of online mediation by making additions to the Law of Ukraine "Mediation" are proposed.
Constitutional law in the system of international law
Authors: Pyroha І. , Byelov D. , Derbak V.
Published: April 2023

The article analyzes the processes of constitutionalization of international law. The purpose of the study is to substantiate the functions and principles of international law that determine the actions of subjects of international legal relations, to assess the potential of constitutional international law to ensure the constitutional legal order. The methodological strategy is built on the synthesis of general scientific and special private law methods. The main emphasis is placed on three main aspects of the constitutionalization of international law: the general values of the international community, the law-making process at the global level of subjects of international law, considered through the prism of the theory of sovereignty. The problem of finding the methodology of constitutional international law is raised. The general values of the international community as a basic prerequisite for the formation of international constitutional law are analyzed, the actions of subjects of international law are evaluated through the prism of the theory of sovereignty, the peculiarities of the norm-making process at the international level in the context of the formation of international constitutional law and the issue of the distribution of competence between different levels of the multi-level system of modern constitutionalism are investigated . The main principles of international constitutionalism are highlighted: limitation of state power in order to ensure human rights, non-use of force or threat of force, territorial integrity of states and inviolability of borders, democratization of social relations, transparency of legislative norms. Observance of these principles acquires constitutional significance in international law. The conclusions indicate the possibility and necessity of distinguishing international constitutional law as an independent field within the framework of international law due to the uniformity of its legal regulation. Considering the consequences of globalization, there is a need to replace the fragmented order based on regional, political, economic, national or cultural characteristics with a global legal order, which is ensured by the constitutionalization of international law.