bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-Comparison between MODIS and VIIRS Snow Cover Products for the 2016 Hydrological Year
Authors: Thapa Shubhechchha , Chhetri Parveen K. , Klein Andrew G.
Published: April 2019

The VIIRS (Visible Infrared Imaging Radiometer Suite) instrument on board the Suomi-NPP (National Polar-Orbiting Partnership) satellite aims to provide long-term continuity of several environmental data series including snow cover initiated with MODIS (Moderate Resolution Imaging Spectroradiometer). Although it is speculated that MODIS and VIIRS snow cover products may differ because of their differing spatial resolutions and spectral coverage, quantitative comparisons between their snow products are currently limited. Therefore, this study intercompares MODIS and VIIRS snow products for the 2016 Hydrological Year over the Midwestern United States and southern Canada. Two hundred and forty-four swath snow products from MODIS/Aqua (MYD10L2) and the VIIRS EDR (Environmental Data Records) (VSCMO/binary) were intercompared using confusion matrices, comparison maps and false color imagery. Thresholding the MODIS NDSI (Normalized Difference Snow Index) Snow Cover product at a snow cover fraction of 30% generated binary snow maps are most comparable to the NOAA VIIRS binary snow product. Overall agreement between MODIS and VIIRS was found to be approximately 98%. This exceeds the VIIRS accuracy requirements of 90% probability of correct typing. The agreement was highest during the winter but lower during late fall and spring. MODIS and VIIRS often mapped snow/no-snow transition zones as a cloud. The assessment of total snow and cloud pixels and comparison snow maps of MODIS and VIIRS indicate that VIIRS is mapping more snow cover and less cloud cover compared to MODIS. This is evidenced by the average area of snow in MYD10L2 and VSCMO being 5.72% and 11.43%, no-snow 26.65% and 28.67% and cloud 65.02% and 59.91%, respectively. While VIIRS and MODIS have a similar capacity to map snow cover, VIIRS has the potential to map snow cover area more accurately, for the successful development of climate data records.
Analysis of High-Efficiency Mo-Based Solar Selective Absorber by Admittance Locus Method
Authors: Chen Hung-Pin , Lee Chao-Te , Liao Wei-Bo , Chang Ya-Chen , Chen Yu-Sheng , Li Meng-Chi , Lee Cheng-Chung , Kuo Chien-Cheng
Published: April 2019

High absorptivity and low emissivity are characteristics needed in an ideal solar selective absorber. In high-temperature applications, such as a solar concentration power system in which the solar surface works under a long-term high temperature (about 400 to 800 °C), the absorber material has to maintain high absorption in the visible region, high reflectance in the infrared region, and excellent thermal stability at high temperature. In this research, the design of a molybdenum-based (Mo-based) solar selective absorber was analyzed by the admittance locus method, and the films were deposited by magnetron sputtering. The ratio of the extinction coefficient to the refractive index of the Mo layer was close to 1, so that the Mo-based solar selective absorber had a broad absorption band, high absorption, and good solar selectivity. Its average reflectance in the visible region was less than 0.4%. The experimental absorption was 97.1% (simulated absorption was 98%) and the emissivity was from 13% to 20% (simulated emissivity was 8% to 26%) as the temperature increased from 400 to 800 °C.
Entropy Balance in the Expanding Universe: A Novel Perspective
Authors: Tozzi Arturo , Peters James F.
Published: April 2019

We describe cosmic expansion as correlated with the standpoints of local observers’ co-moving horizons. In keeping with relational quantum mechanics, which claims that quantum systems are only meaningful in the context of measurements, we suggest that information gets ergodically “diluted” in our isotropic and homogeneous expanding Universe, so that an observer detects just a limited amount of the total cosmic bits. The reduced bit perception is due the decreased density of information inside the expanding cosmic volume in which the observer resides. Further, we show that the second law of thermodynamics can be correlated with cosmic expansion through a relational mechanism, because the decrease in information detected by a local observer in an expanding Universe is concomitant with an increase in perceived cosmic thermodynamic entropy, via the Bekenstein bound and the Laudauer principle. Reversing the classical scheme from thermodynamic entropy to information, we suggest that the cosmological constant of the quantum vacuum, which is believed to provoke the current cosmic expansion, could be one of the sources of the perceived increases in thermodynamic entropy. We conclude that entropies, including the entangled entropy of the recently developed framework of quantum computational spacetime, might not describe independent properties, but rather relations among systems and observers.
Exponential Strong Converse for Successive Refinement with Causal Decoder Side Information
Authors: Zhou Lin , Hero Alfred
Published: April 2019

We consider the k-user successive refinement problem with causal decoder side information and derive an exponential strong converse theorem. The rate-distortion region for the problem can be derived as a straightforward extension of the two-user case by Maor and Merhav (2008). We show that for any rate-distortion tuple outside the rate-distortion region of the k-user successive refinement problem with causal decoder side information, the joint excess-distortion probability approaches one exponentially fast. Our proof follows by judiciously adapting the recently proposed strong converse technique by Oohama using the information spectrum method, the variational form of the rate-distortion region and Hölder’s inequality. The lossy source coding problem with causal decoder side information considered by El Gamal and Weissman is a special case ( k = 1 ) of the current problem. Therefore, the exponential strong converse theorem for the El Gamal and Weissman problem follows as a corollary of our result.
Influence of Freeze/Thaw Cycles on Mechanical and Thermal Properties of Masonry Wall and Masonry Wall Materials
Authors: Netinger Grubeša Ivanka , Teni Mihaela , Krstić Hrvoje , Vračević Martina
Published: April 2019

In this study, the influence of freeze/thaw cycles on the mechanical and thermal properties of bricks and mortar as building parts of masonry walls, as well as the influence on the masonry wall itself is investigated. At the material level, the influence of freeze and thaw cycles on the mechanical and thermal properties of masonry components (bricks and mortar) was investigated; at the construction level, the influence of freeze and thaw cycles on the mechanical and thermal properties of a masonry wall was studied. To study the influence of freezing on the energy demand characteristics of masonry buildings, in terms of energy conservation and greenhouse gas emission, a case study was investigated on a typical structure of a historical building located in Croatia, that had undergone a process of energy certification. The applied freeze/thaw regime negatively influenced the compressive strength and the thermal properties of bricks and mortar, as well as the mechanical and thermal properties of the wall. Considering the thermal properties of the material before and after its exposure to freeze/thaw cycles, we concluded that the annual energy consumption, the heating costs, and the CO2 emission of a family house could increase up to 3.7% after frost action in the studied case.
Investigation on the Resonant Oscillations in an 11 kV Distribution Transformer under Standard and Chopped Lightning Impulse Overvoltages with Different Shield Placement Configurations
Authors: Srikanta Murthy Avinash , Azis Norhafiz , Mohd Yousof Mohd Fairouz , Jasni Jasronita , Othman Mohammad Lutfi , Talib Mohd Aizam , Das Bhaba Priyo
Published: April 2019

This paper presents an investigation on the resonant oscillations of an 11 kV layer-type winding transformer under standard and chopped lightning impulse overvoltage conditions based on calculated parameters. The resistances, inductances and capacitances were calculated in order to develop the transformer winding equivalent circuit. The impulse overvoltages were applied to the high voltage (HV) winding and the resonant oscillations were simulated for each of the layers based on different electrostatic shield placement configurations. It is found that the placement of grounded shields between layer 13 and layer 14 results in the highest resonant oscillation and non-linear initial voltage distribution. The oscillation and linear stress distributions are at the lowest for shield placement between the HV and low voltage (LV) windings.
Effects of Lime Application and Understory Removal on Soil Microbial Communities in Subtropical Eucalyptus L’Hér. Plantations
Authors: Wan Songze , Liu Zhanfeng , Chen Yuanqi , Zhao Jie , Ying Qin , Liu Juan
Published: April 2019

Soil microorganisms play key roles in ecosystems and respond quickly to environmental changes. Liming and/or understory removal are important forest management practices and have been widely applied to planted forests in humid subtropical and tropical regions of the world. However, few studies have explored the impacts of lime application, understory removal, and their interactive effects on soil microbial communities. We conducted a lime application experiment combined with understory removal in a subtropical Eucalyptus L’Hér. plantation. Responses of soil microbial communities (indicated by phospholipid fatty acids, PLFAs), soil physico-chemical properties, and litter decomposition rate to lime and/or understory removal were measured. Lime application significantly decreased both fungal and bacterial PLFAs, causing declines in total PLFAs. Understory removal reduced the fungal PLFAs but had no effect on the bacterial PLFAs, leading to decreases in the total PLFAs and in the ratio of fungal to bacterial PLFAs. No interaction between lime application and understory removal on soil microbial community compositions was observed. Changes in soil microbial communities caused by lime application were mainly attributed to increases in soil pH and NO3–-N contents, while changes caused by understory removal were mainly due to the indirect effects on soil microclimate and the decreased soil dissolved carbon contents. Furthermore, both lime application and understory removal significantly reduced the litter decomposition rates, which indicates the lime application and understory removal may impact the microbe-mediated soil ecological process. Our results suggest that lime application may not be suitable for the management of subtropical Eucalyptus plantations. Likewise, understory vegetation helps to maintain soil microbial communities and litter decomposition rate; it should not be removed from Eucalyptus plantations.
Carbon Storage Dynamics of Secondary Forest Succession in the Central Loess Plateau of China
Authors: Yang Bin , Zhang Wenhui , Lu Yanlei , Zhang Weiwei , Wang Yanan
Published: April 2019

Research Highlights: This study comprehensively revealed the carbon sequestration characteristics of secondary forests in the central Loess Plateau during vegetation succession. Background and Objectives: The secondary succession of Loess Plateau forests is of great significance in global climate change, but their carbon storage dynamics are poorly understood. The study objectives were to clarify the pattern of changes and contribution level of carbon stocks in various components of ecosystem during succession. Materials and Methods: We selected 18 plots for Pinus tabuliformis Carr. forest at the early stage of succession, 19 for pine-broadleaved mixed forest at the middle stage, and 12 for Quercus-broadleaved mixed forest at the climax stage to determine the tree, shrub, herb, fine root, litter, coarse wood debris (CWD), and soil carbon stocks. Results: Ecosystem carbon stocks increased from 160.73 to 231.14 Mg·ha−1 with the succession stages. Vegetation (including tree, shrub and herb) and soil were the two largest carbon pools, and carbon was mainly sequestrated in tree biomass and shallow soil (0–50 cm). In the early stage, soil contributed more carbon stocks to the ecosystem than vegetation, but with succession, the soil contribution decreased while vegetation contribution increased, finally reaching a balance (46.78% each) at the climax stage. Fine root, litter, and CWD contributed little (average 6.59%) to ecosystem carbon stocks and were mainly involved in the turnover of vegetation biomass to soil carbon. Conclusions: Our results provide direct evidence for carbon sequestration of secondary forests on the Loess Plateau. The dynamic results of carbon storage provide an important basis for forest restoration management under climate change.
Physicochemical Properties and Pollen Profile of Oak Honeydew and Evergreen Oak Honeydew Honeys from Spain: A Comparative Study
Authors: Seijo María Carmen , Escuredo Olga , Rodríguez-Flores María Shantal
Published: April 2019

This work investigates the similarities and differences of oak honeydew (Quercus pyrenaica Willd.) and evergreen honeydew (Quercus ilex L.) honey produced in Spain. For this purpose, the physicochemical characteristics of 17 samples from oak honeydew and 11 samples from evergreen honeydew collected in different geographical regions were analyzed. All the samples accomplished European Union requirements for honey consumption. Both honey types had amber dark color; however, the evergreen oak honey was clearer than oak honey, having higher mean values in a* and b* coordinates of CIELab scale. In general, both honey types exhibited high electrical conductivity, a moderate value of pH, medium to low water content, and high diastase activity. The reducing sugar content was significantly lower and maltose content was significantly higher in evergreen honeydew. In addition, total phenols and total flavonoid contents, the antioxidant activity and the melissopalynological analysis was performed. The oak honeydew honey had a higher abundance of Castanea, Rubus and Erica pollen grains, while the evergreen oak honeydew honey had a higher abundance of Lavandula, Olea europaea or Anthyllis cytisoides. A multivariate analysis using the most representative pollen types and physicochemical components facilitated the differentiation of the honey samples, thus this information can be useful for the honey characterization.
Existence Theorems for Mixed Riemann–Liouville and Caputo Fractional Differential Equations and Inclusions with Nonlocal Fractional Integro-Differential Boundary Conditions
Authors: Ntouyas Sotiris K. , Alsaedi Ahmed , Ahmad Bashir
Published: April 2019

In this paper, we discuss the existence and uniqueness of solutions for a new class of single and multi-valued boundary value problems involving both Riemann–Liouville and Caputo fractional derivatives, and nonlocal fractional integro-differential boundary conditions. Our results rely on modern tools of functional analysis. We also demonstrate the application of the obtained results with the aid of examples.
Geological and Structural Control on Localized Ground Effects within the Heunghae Basin during the Pohang Earthquake (MW 5.4, 15th November 2017), South Korea
Authors: Naik Sambit , Kim Young-Seog , Kim Taehyung , Su-Ho Jeong
Published: April 2019

On 15th November 2017, the Pohang earthquake (Mw 5.4) had strong ground shaking that caused severe liquefaction and lateral spreading across the Heunghae Basin, around Pohang city, South Korea. Such liquefaction is a rare phenomenon during small or moderate earthquakes (MW < 5.5). There are only a few examples around the globe, but more so in the Korean Peninsula. In this paper, we present the results of a systematic survey of the secondary ground effects—i.e., soil liquefaction and ground cracks—developed during the earthquake. Most of the liquefaction sites are clustered near the epicenter and close to the Heunghae fault. Based on the geology, tectonic setting, distribution, and clustering of the sand boils along the southern part of the Heunghae Basin, we propose a geological model, suggesting that the Heunghae fault may have acted as a barrier to the propagation of seismic waves. Other factors like the mountain basin effect and/or amplification of seismic waves by a blind thrust fault could play an important role. Liquefaction phenomenon associated with the 2017 Pohang earthquake emphasizes that there is an urgent need of liquefaction potential mapping for the Pohang city and other areas with a similar geological setting. In areas underlain by extensive unconsolidated basin fill sediments—where the records of past earthquakes are exiguous or indistinct and there is poor implementation of building codes—future earthquakes of similar or larger magnitude as the Pohang earthquake are likely to occur again. Therefore, this represents a hazard that may cause significant societal and economic threats in the future.
The Future Modernism of No-Oil Norway: Øyvind Rimbereid’s “Solaris Corrected”
Authors: Andersen Per Thomas
Published: April 2019

The article is a literary analysis of the poem “Solaris Corrected” by the Norwegian poet Øyvind Rimbereid. The work is a poetical science fiction where the oil industry in the North Sea is seen from a retrospective point of view, conveyed in a future language. As a part of the modernist tradition in Scandinavian literature, Rimbereid’s work can be read as a significant renewal of the poetic heritage from among others Rolf Jacobsen and Harry Martinson.
Aeroponic Cloning of Capsicum spp.
Authors: Del Valle-Echevarria Angel R. , Kantar Michael B. , Branca Julianne , Moore Sarah , Frederiksen Matthew K. , Hagen Landon , Hussain Tanveer , Baumler David J.
Published: April 2019

Aeroponic cloning is a great strategy to maintain desired genotypes by generating a whole new plant from cuttings. While this propagation technique has been demonstrated for tomatoes (Solanum lycopersicum) and potatoes (Solanum tuberosum), no protocol has been developed for peppers (Capsicum spp.). The ability to clonally propagate different Capsicum holds promise for domestic and industrial growing operations since elite cultivars with desirable traits (e.g., high capsaicin levels, nutrient content, and striped fruit) can be perpetuated without the need of planning a nursery. We tested six Capsicum species for their feasibility of aeroponic cloning by stem cuttings. All domestic species were successfully regenerated under aeroponic conditions but not for Capsicum eximium, a wild species. Of the species analyzed, Capsicum annuum peppers had the fastest node formation (11.6 +/− 0.89 days, P ≤ 0.01) and obtained a larger volume of roots (P ≤ 0.01) after node formation as compared to C. baccatum, C. frutescens, and C. pubescens. This study presents a cost-effective strategy to clonally propagate peppers for personal, industrial, and conservation purposes.
Serianthes nelsonii Seed Germination and Seedling Behavior are Minimally Influenced by Chemical and Light Treatment
Authors: Marler Thomas
Published: April 2019

The role of seed imbibition and light during germination are not known for the critically endangered Serianthes nelsonii Merr. Scarified seeds were pre-soaked in gibberellic acid (GA3) up to 300 mg/L and nitrate solutions of 3000 mg/L to determine if germination was influenced by these treatments. Scarified and imbibed seeds were incubated in high red:far red and low red:far red light to determine the influence of light quality on germination traits. The GA3 and nitrate treatments did not influence germination percentage or timing, but did increase the height of newly emerged seedlings. Moreover, GA3 extended the longevity of cotyledons and shortened the window of time that seedlings required to resume height growth. These growth responses were not sustained, and all seedlings reached heights of 30 cm at a similar number of weeks. The light treatments did not influence any of the germination response traits. The results indicate that imbibing seeds with chemical solutions and providing light in a range of light quality treatments exerted a minimal influence on S. nelsonii seed germination behaviors. Imbibing seeds with water and germinating in darkness is sufficient for achieving the germination of this endangered tree species.
Adoption and Impacts of Integrated Pest Management in Bangladesh: Evidence from Smallholder Bitter Gourd Growers
Authors: Rahman Md. Sadique , Norton George W.
Published: April 2019

Determinants of integrated pest management (IPM) adoption, productivity and efficiency of bitter gourd (Momordica charantia L.) growers in Bangladesh were jointly measured using propensity score matching (PSM), sample selection stochastic frontier production function (SFPF) and inverse probability weighted regression adjustment (IPWRA) techniques. The significant value (P < 0.05) of the selectivity variable (ρ(w,v)) coefficient justifies the use of the sample selection SFPF. The decision to adopt IPM was positively influenced by the training and other farmers’ decisions to adopt. Mean technical efficiency (MTE) was found to be significantly higher for adopters (0.59) compared to non-adopters (0.40). The MTE analysis suggests that arranging more training sessions and making farmers more familiar with the IPM practices would improve the technical efficiency of the growers. Adoption of IPM practices significantly reduced the number pesticide applications, which imply environmental benefits from their adoption.
Children’s Transport Built Environments: A Mixed Methods Study of Associations between Perceived and Objective Measures and Relationships with Parent Licence for Independent Mobility in Auckland, New Zealand
Authors: Smith Melody , Amann Rebecca , Cavadino Alana , Raphael Deborah , Kearns Robin , Mackett Roger , Mackay Lisa , Carroll Penelope , Forsyth Euan , Mavoa Suzanne , Zhao Jinfeng , Ikeda Erika , Witten Karen
Published: April 2019

Children’s independent mobility is declining internationally. Parents are the gatekeepers of children’s independent mobility. This mixed methods study investigates whether parent perceptions of the neighbourhood environment align with objective measures of the neighbourhood built environment, and how perceived and objective measures relate to parental licence for children’s independent mobility. Parents participating in the Neighbourhood for Active Kids study (n = 940) answered an open-ended question about what would make their neighbourhoods better for their child’s independent mobility, and reported household and child demographics. Objective measures of the neighbourhood built environment were generated using geographic information systems. Content analysis was used to classify and group parent-reported changes required to improve their neigbourhood. Parent-reported needs were then compared with objective neighbourhood built environment measures. Linear mixed modelling examined associations between parental licence for independent mobility and (1) parent neighbourhood perceptions; and (2) objectively assessed neighbourhood built environment features. Parents identified the need for safer traffic environments. No significant differences in parent reported needs were found by objectively assessed characteristics. Differences in odds of reporting needs were observed for a range of socio-demographic characteristics. Parental licence for independent mobility was only associated with a need for safer places to cycle (positive) and objectively assessed cycling infrastructure (negative) in adjusted models. Overall, the study findings indicate the importance of safer traffic environments for children’s independent mobility.
Investigation into Micropollutant Removal from Wastewaters by a Membrane Bioreactor
Authors: Kamaz Mohanad , Wickramasinghe S. Ranil , Eswaranandam Satchithanandam , Zhang Wen , Jones Steven M. , Watts Michael J. , Qian Xianghong
Published: April 2019

Direct potable reuse of wastewater is attractive as the demand for potable water increases. However, the presence of organic micropollutants in industrial and domestic wastewater is a major health and environmental concern. Conventional wastewater treatment processes are not designed to remove these compounds. Further many of these emerging pollutants are not regulated. Membrane bioreactor based biological wastewater treatment has recently become a preferred method for treating municipal and other industrial wastewaters. Here the removal of five selected micropollutants representing different classes of emerging micropollutants has been investigated using a membrane bioreactor. Acetaminophen, amoxicillin, atrazine, estrone, and triclosan were spiked into wastewaters obtained from a local wastewater treatment facility prior to introduction to the membrane bioreactor containing both anoxic and aerobic tanks. Removal of these compounds by adsorption and biological degradation was determined for both the anoxic and aerobic processes. The removal as a function of operating time was investigated. The results obtained here suggest that removal may be related to the chemical structure of the micropollutants.
Prevalence of Noise-Induced Hearing Loss Among Tanzanian Iron and Steel Workers: A Cross-Sectional Study
Authors: Nyarubeli Israel P. , Tungu Alexander M. , Moen Bente E. , Bråtveit Magne
Published: April 2019

Iron and steel factory workers in Tanzania are likely to develop noise-induced hearing loss (NIHL) due to exposure to high sound levels. Studies on hearing status in this population are lacking. The aims of this study were to determine prevalence of NIHL among iron and steel workers and compare hearing thresholds at different frequencies with a control group. We conducted a cross-sectional study among 221 iron and steel workers exposed to average noise level of 92 dB(A), compared with 107 primary school teachers recruited as controls and exposed to average noise level of 79.7 dB(A). We used a questionnaire-based interview to collect information on socio demographic characteristics and other confounding variables. Hearing loss was defined as hearing threshold levels ≥25 dB hearing loss in either ear at 3000, 4000 or 6000 Hz. The prevalence of hearing loss was significantly higher among the exposed group than among the controls, i.e. 48% and 31%, respectively. There were significant differences in hearing thresholds between the exposed and control groups at 3000, 4000, 6000, and 8000 Hz. Hearing loss was more frequent among workers exposed to higher noise levels than among the controls suggesting that iron and steel workers run a higher risk of developing hearing loss.
Investigating the Aftershock of a Disaster: A Study of Health Service Utilization and Mental Health Symptoms in Post-Earthquake Nepal
Authors: Powell Tara , Li Shang-Ju , Hsiao Yuan , Ettari Chloe , Bhandari Anish , Peterson Anne , Shakya Niva
Published: April 2019

Background: In 2015, a 7.8 magnitude earthquake struck Nepal, causing unprecedented damage and loss in the mountain and hill regions of central Nepal. The aim of this study was to investigate the association between healthcare access and utilization, and post-disaster mental health symptoms. Methods: A cross-sectional study conducted with 750 disaster-affected individuals in six districts in central Nepal 15 months post-earthquake. Anxiety and depression were measured through the Depression, Anxiety and Stress Scale (DASS-21). Healthcare utilization questions examined types of healthcare in the communities, utilization, and approachability of care providers. Univariate analyses, ANOVAs and Tobit regression were used. Results: Depression and anxiety symptoms were significantly higher for females and individuals between 40–50 years old. Those who utilized a district hospital had the lowest anxiety and depression scores. Participants who indicated medical shops were the most important source of health-related information had more anxiety and depression than those who used other services. Higher quality of healthcare was significantly associated with fewer anxiety and depressive symptoms. Conclusions: Mental health symptoms can last long after a disaster occurs. Access to quality mental health care in the primary health care settings is critical to help individuals and communities recover immediately and during the long-term recovery.
Evaluation of Secondhand Smoke Using PM2.5 and Observations in a Random Stratified Sample in Hospitality Venues from 12 Cities
Authors: Kaplan Bekir , Carkoglu Asli , Ergor Gul , Hayran Mutlu , Sureda Xisca , Cohen Joanna E , Navas-Acien Ana
Published: April 2019

Background: Turkey passed a law banning smoking in all indoor public places in 2008. In response to the indoor smoking restriction, many smokers may have relocated to outdoor areas of venues. The aim of this study was to evaluate air pollution related to SHS exposure in indoor and outdoor areas of hospitality venues in 12 cities in Turkey. Method: In this cross-sectional study, we evaluated hospitality venues in 12 cities in Turkey. In each visited venue, we evaluated a pre-specified number of study locations such as the outdoor area of the main entrance, indoor areas, and patios or other outdoor dining areas, completely or partially covered with window walls. We measured particulate matter 2.5 (PM2.5) in those areas. Results: The fieldworkers visited 72 randomly selected hospitality venues and measured PM2.5 concentrations in 165 different locations (indoor, outdoor, and patios) of those venues. Overall, 2573 people were observed, 909 of them smoking. The median (IQR) PM2.5 concentrations were 95 (39–229) μg/m3 indoors, 25 (13–48) μg/m3 outdoors, and 31 μg/m3 (16–62) in the patios (p < 0.001). After adjustment, each additional smoker was associated with a 2% increase in PM2.5 concentrations in patio air (GMR (95% CI): 1.02 (1.00, 1.05), and a 4% increase in indoor air (GMR (95% CI): 1.04 (1.02, 1.05). Conclusions: There were unhealthy levels of smoking-caused PM2.5 concentrations, not only indoors, but also in the patios of hospitality venues. Legislative efforts to expand the smoke-free legislation to outdoor areas adjacent to indoor public places and an action plan to increase compliance with the smoke-free policy are urgently needed in Turkey.
Who Should Play a Key Role in Preventing Common Mental Disorders that Affect Employees in the Workplace? Results of a Survey with Occupational Health Physicians, Primary Care Physicians, Psychotherapists, and Human Resource Managers
Authors: Michaelis Martina , Balint Elisabeth Maria , Junne Florian , Zipfel Stephan , Gündel Harald , Lange Rahna , Rieger Monika A. , Rothermund Eva
Published: April 2019

The rising burden of common mental disorders (CMDs) in employees requires strategies for prevention. No systematic data exist about how those involved perceive their roles, responsibilities, and interactions with other professional groups. Therefore, we performed a multi-professional standardized survey with health professionals in Germany. A self-administered questionnaire was completed by 133 occupational health physicians (OHPs), 136 primary care physicians (PCPs), 186 psychotherapists (PTs), and 172 human resource managers (HRMs). Inter alia, they were asked which health professionals working in the company health service and in the outpatient care or in the sector of statutory insurance agents should play a key role in the primary, secondary, and tertiary prevention of CMDs in employees. The McNemar test was used in order to compare the attributed roles among the professionals involved. With regard to CMDs, all the professional groups involved in this study declared OHPs as the most relevant pillar in the field of prevention. In primary prevention, HRMs regarded themselves, OHPs, and health insurance agents as equally relevant in terms of prevention. PTs indicated an important role for employee representatives in this field. In secondary prevention, PCPs were regarded as important as OHPs. HRMs indicated themselves as equally important as OHPs and PCPs. In tertiary prevention, only OHPs identified themselves as main protagonists. The other groups marked a variety of several professions. There is a common acceptance from the parties involved that might help the first steps be taken toward overcoming barriers, e.g., by developing a common framework for quality-assured intersectional cooperation in the field of CMD prevention in employees.
LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer
Authors: Bonanno Laura , Zulato Elisabetta , Pavan Alberto , Attili Ilaria , Pasello Giulia , Conte PierFranco , Indraccolo Stefano
Published: April 2019

Liver kinase B1 (LKB1) is a tumor suppressor gene whose inactivation is frequent in different tumor types, especially in lung adenocarcinoma (about 30% of cases). LKB1 has an essential role in the control of cellular redox homeostasis by regulating ROS production and detoxification. Loss of LKB1 makes the tumor cell more sensitive to oxidative stress and consequently to stress-inducing treatments, such as chemotherapy and radiotherapy. LKB1 loss triggers complex changes in tumor microenvironment, supporting a role in the regulation of angiogenesis and suggesting a potential role in the response to anti-angiogenic treatment. On the other hand, LKB1 deficiency can promote an immunosuppressive microenvironment and may be involved in primary resistance to anti-PD-1/anti-PD-L1, as it has been reported in lung cancer. The aim of this review is to discuss interactions of LKB1 with the tumor microenvironment and the potential applications of this knowledge in predicting response to treatment in lung cancer.
Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder
Authors: Barone Rita , Rizzo Renata , Tabbì Giovanni , Malaguarnera Michele , Frye Richard E. , Bastin Jean
Published: April 2019

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by defective social communication and interaction and restricted, repetitive behavior with a complex, multifactorial etiology. Despite an increasing worldwide prevalence of ASD, there is currently no pharmacological cure to treat core symptoms of ASD. Clinical evidence and molecular data support the role of impaired mitochondrial fatty acid oxidation (FAO) in ASD. The recognition of defects in energy metabolism in ASD may be important for better understanding ASD and developing therapeutic intervention. The nuclear peroxisome proliferator-activated receptors (PPAR) α, δ, and γ are ligand-activated receptors with distinct physiological functions in regulating lipid and glucose metabolism, as well as inflammatory response. PPAR activation allows a coordinated up-regulation of numerous FAO enzymes, resulting in significant PPAR-driven increases in mitochondrial FAO flux. Resveratrol (RSV) is a polyphenolic compound which exhibits metabolic, antioxidant, and anti-inflammatory properties, pointing to possible applications in ASD therapeutics. In this study, we review the evidence for the existing links between ASD and impaired mitochondrial FAO and review the potential implications for regulation of mitochondrial FAO in ASD by PPAR activators, including RSV.
Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells
Authors: Adámková Ljubina , Kvíčalová Zuzana , Rozbeský Daniel , Kukačka Zdeněk , Adámek David , Cebecauer Marek , Novák Petr
Published: April 2019

Mouse activating Nkrp1 proteins are commonly described as type II transmembrane receptors with disulfide-linked homodimeric structure. Their function and the manner in which Nkrp1 proteins of mouse strain (C57BL/6) oligomerize are still poorly understood. To assess the oligomerization state of Nkrp1 proteins, mouse activating EGFP-Nkrp1s were expressed in mammalian lymphoid cells and their oligomerization evaluated by Förster resonance energy transfer (FRET). Alternatively, Nkrp1s oligomers were detected by Western blotting to specify the ratio between monomeric and dimeric forms. We also performed structural characterization of recombinant ectodomains of activating Nkrp1 receptors. Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface. Cysteine-to-serine mutants revealed the importance of all stalk cysteines for protein dimerization in living cells with a major influence of cysteine at position 74 in two Nkrp1 protein isoforms. Our results represent a new insight into the oligomerization of Nkrp1 receptors on lymphoid cells, which will help to determine their function.
Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism
Authors: Zhang Li , Yao Weilei , Xia Jun , Wang Tongxin , Huang Feiruo
Published: April 2019

The liver is the central organ of glycolipid metabolism, which regulates the metabolism of lipids and glucose to maintain energy homeostasis upon alterations of physiological conditions. Researchers formerly focused on the phosphorylation of glucagon in controlling liver metabolism. Noteworthily, emerging evidence has shown glucagon could additionally induce acetylation to control hepatic metabolism in response to different physiological states. Through inducing acetylation of complex metabolic networks, glucagon interacts extensively with various energy-sensing factors in shifting from glucose metabolism to lipid metabolism during prolonged fasting. In addition, glucagon-induced acetylation of different energy-sensing factors is involved in the advancement of nonalcoholic fatty liver disease (NAFLD) to liver cancer. Here, we summarize the latest findings on glucagon to control hepatic metabolism by inducing acetylation of energy-sensing factors. Finally, we summarize and discuss the potential impact of glucagon on the treatment of liver diseases.
Comparison of Proton and Photon Beam Irradiation in Radiation-Induced Intestinal Injury Using a Mouse Model
Authors: Choi Changhoon , Lee Chansu , Shin Sung-Won , Kim Shin-Yeong , Hong Sung Noh , Park Hee Chul
Published: April 2019

When radiotherapy is applied to the abdomen or pelvis, normal tissue toxicity in the gastrointestinal (GI) tract is considered a major dose-limiting factor. Proton beam therapy has a specific advantage in terms of reduced doses to normal tissues. This study investigated the fundamental differences between proton- and X-ray-induced intestinal injuries in mouse models. C57BL/6J mice were irradiated with 6-MV X-rays or 230-MeV protons and were sacrificed after 84 h. The number of surviving crypts per circumference of the jejunum was identified using Hematoxylin and Eosin staining. Diverse intestinal stem cell (ISC) populations and apoptotic cells were analyzed using immunohistochemistry (IHC) and a terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) assay, respectively. The crypt microcolony assay revealed a radiation-dose-dependent decrease in the number of regenerative crypts in the mouse jejunum; proton irradiation was more effective than X-ray irradiation with a relative biological effectiveness of 1.14. The jejunum is the most sensitive to radiations, followed by the ileum and the colon. Both types of radiation therapy decreased the number of radiosensitive, active cycling ISC populations. However, a higher number of radioresistant, reserve ISC populations and Paneth cells were eradicated by proton irradiation than X-ray irradiation, as shown in the IHC analyses. The TUNEL assay revealed that proton irradiation was more effective in enhancing apoptotic cell death than X-ray irradiation. This study conducted a detailed analysis on the effects of proton irradiation versus X-ray irradiation on intestinal crypt regeneration in mouse models. Our findings revealed that proton irradiation has a direct effect on ISC populations, which may result in an increase in the risk of GI toxicity during proton beam therapy.
Comparative Transcriptomic Studies on a Cadmium Hyperaccumulator Viola baoshanensis and Its Non-Tolerant Counterpart V. inconspicua
Authors: Shu Haoyue , Zhang Jun , Liu Fuye , Bian Chao , Liang Jieliang , Liang Jiaqi , Liang Weihe , Lin Zhiliang , Shu Wensheng , Li Jintian , Shi Qiong , Liao Bin
Published: April 2019

Many Viola plants growing in mining areas exhibit high levels of cadmium (Cd) tolerance and accumulation, and thus are ideal organisms for comparative studies on molecular mechanisms of Cd hyperaccumulation. However, transcriptomic studies of hyperaccumulative plants in Violaceae are rare. Viola baoshanensis is an amazing Cd hyperaccumulator in metalliferous areas of China, whereas its relative V. inconspicua is a non-tolerant accumulator that resides at non-metalliferous sites. Here, comparative studies by transcriptome sequencing were performed to investigate the key pathways that are potentially responsible for the differential levels of Cd tolerance between these two Viola species. A cascade of genes involved in the ubiquitin proteosome system (UPS) pathway were observed to have constitutively higher transcription levels and more activation in response to Cd exposure in V. baoshanensis, implying that the enhanced degradation of misfolded proteins may lead to high resistance against Cd in this hyperaccumulator. Many genes related to sucrose metabolism, especially those involved in callose and trehalose biosynthesis, are among the most differentially expressed genes between the two Viola species, suggesting a crucial role of sucrose metabolism not only in cell wall modification through carbon supply but also in the antioxidant system as signaling molecules or antioxidants. A comparison among transcriptional patterns of some known transporters revealed that several tonoplast transporters are up-regulated in V. baoshanensis under Cd stress, suggesting more efficient compartmentalization of Cd in the vacuoles. Taken together, our findings provide valuable insight into Cd hypertolerance in V. baoshanensis, and the corresponding molecular mechanisms will be useful for future genetic engineering in phytoremediation.
Bacterial Isolate Inhabiting Spitsbergen Soil Modifies the Physiological Response of Phaseolus coccineus in Control Conditions and under Exogenous Application of Methyl Jasmonate and Copper Excess
Authors: Hanaka Agnieszka , Nowak Artur , Plak Andrzej , Dresler Sławomir , Ozimek Ewa , Jaroszuk-Ściseł Jolanta , Wójciak-Kosior Magdalena , Sowa Ireneusz
Published: April 2019

The aim of the study was to demonstrate the potential of the promotion and regulation of plant physiology and growth under control and copper stress conditions, and the impact of the exogenous application of methyl jasmonate on this potential. Runner bean plants were treated with methyl jasmonate (1 or 10 µM) (J; J1 or J10) and Cu (50 µM), and inoculated with a bacterial isolate (S17) originating from Spitsbergen soil, and identified as Pseudomonas luteola using the analytical profile index (API) test. Above- and under-ground plant parts were analyzed. The growth parameters; the concentration of the photosynthetic pigments, elements, flavonoids (FLAVO), phenolics (TPC), allantoin (ALLA), and low molecular weight organic acids (LMWOAs); the activity of antioxidant enzymes and enzymes of resistance induction pathways (e.g., superoxide dismutase (SOD), catalase (CAT), ascorbate (APX) and guaiacol (GPX) peroxidase, glucanase (GLU), and phenylalanine (PAL) and tyrosine ammonia-lyase (TAL)), and the antioxidant capacity (AC) were studied. The leaves exhibited substantially higher ALLA and LMWOA concentrations as well as PAL and TAL activities, whereas the roots mostly had higher activities for a majority of the enzymes tested (i.e., SOD, CAT, APX, GPX, and GLU). The inoculation with S17 mitigated the effect of the Cu stress. Under the Cu stress and in the presence of J10, isolate S17 caused an elevation of the shoot fresh weight, K concentration, and TAL activity in the leaves, and APX and GPX (also at J1) activities in the roots. In the absence of Cu, isolate S17 increased the root length and the shoot-to-root ratio, but without statistical significance. In these conditions, S17 contributed to a 236% and 34% enhancement of P and Mn, respectively, in the roots, and a 19% rise of N in the leaves. Under the Cu stress, S17 caused a significant increase in FLAVO and TPC in the leaves. Similarly, the levels of FLAVO, TPC, and AC were enhanced after inoculation with Cu and J1. Regardless of the presence of J, inoculation at Cu excess caused a reduction of SOD and CAT activities, and an elevation of GPX. The effects of inoculation were associated with the application of Cu and J, which modified plant response mainly in a concentration-dependent manner (e.g., PAL, TAL, and LMWOA levels). The conducted studies demonstrated the potential for isolate S17 in the promotion of plant growth.
User Education in Automated Driving: Owner’s Manual and Interactive Tutorial Support Mental Model Formation and Human-Automation Interaction
Authors: Forster Yannick , Hergeth Sebastian , Naujoks Frederik , Krems Josef , Keinath Andreas
Published: April 2019

Automated driving systems (ADS) and a combination of these with advanced driver assistance systems (ADAS) will soon be available to a large consumer population. Apart from testing automated driving features and human–machine interfaces (HMI), the development and evaluation of training for interacting with driving automation has been largely neglected. The present work outlines the conceptual development of two possible approaches of user education which are the owner’s manual and an interactive tutorial. These approaches are investigated by comparing them to a baseline consisting of generic information about the system function. Using a between-subjects design, N = 24 participants complete one training prior to interacting with the ADS HMI in a driving simulator. Results show that both the owner’s manual and an interactive tutorial led to an increased understanding of driving automation systems as well as an increased interaction performance. This work contributes to method development for the evaluation of ADS by proposing two alternative approaches of user education and their implications for both application in realistic settings and HMI testing.
Hymenoptera Complex Associated with Myzus persicae and Hyalopterus spp. in Peach Orchards in Northeastern Spain and Prospects for Biological Control of Aphids
Authors: Aparicio Yahana , Gabarra Rosa , Riudavets Jordi , Starý Petr , Tomanović Željko , Kocić Korana , Pujade Villar Juli , Ferrer Suay Mar , Cuesta Porta Victor , Arnó Judit
Published: April 2019

Aphids are a serious pest for peach crops. They have traditionally been managed with insecticides, but there is increasing concern about the risk that insecticides pose to both humans and the environment. As a first step to use biological control in aphid management, we conducted a 3-year field survey in northeastern Spain to determine which parasitoids and hyperparasitoids were most prevalent on two aphids, Myzus persicae (Sulzer) and Hyalopterus spp. Koch, the most harmful to peach trees. We collected 11 parasitoid species from M. persicae, with Aphidius matricariae (Haliday) being the most abundant. Two parasitoid species were also collected from Hyalopterus spp., Aphidius transcaspicus Telenga and Praon volucre (Haliday). Hyperparasitoid species overlapped between these aphids but their relative abundances differed. We also discuss the possible impacts of hyperparasitoids on parasitoid populations. Our results suggest that it would be feasible to implement biocontrol methods for aphids in integrated pest management programmes in peach orchards. There are a number of primary parasitoid species associated with these aphids, and the nearby crops and wild vegetation in the vicinity and within the orchards may provide a suitable habitat for them. Additionally, some of them are commercially available and might be usable in augmentative releases.