bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Patient Primigravida 36-37 Weeks with Chronic Myeloid Leukemia, Anemia, and Thrombocytopenia: A Case Report
Authors: Yusuf Muhammad Farlyzhar , Hartono Ruddi
Published: November 2021

Chronic myelogenous leukemia (CML) is a type of cancer caused by a disturbance in the hematopoietic stem cells. CML itself rarely occur on women who are in labor and an advanced procedure in this event has become a special challenge for medics, especially an anesthesiologist. This limits the development of standard anesthesia guidelines, so in this case we describe the incidence of CML in pregnancies performed by Cesarean section with general anesthesia.

The first pregnant patient was 36 weeks pregnant; the patient was first diagnosed with Chronic myelogenous leukemia (CML) at the age of 26-28 weeks, at that time the patient complained of frequent dizziness, abdominal pain and weakness, then the patient complained of bleeding gums, and currently the patient complained of nosebleeds. The Bone Marrow shows Conclusion an accelerated phase chronic myeloid leukemia (CML) (suspected atypical CML) with nutritional deficiency. We perform General Anesthesia technique Rapid Sequence Intubation with Regimen Fentanyl 100 mcg, Propofol 80 mg and Rocuronium 50 mg.

The patient was admitted to the ICU for 2 days before transferring to intensive care and the patient received intravenous paracetamol 1 gram four times, cefazolin 1 gram twice a day, lansoprazole 30 mg once a day, tranexamic acid 1gr three times a day, and 15 mcg per hour fentanyl contionously. Hemodynamic patients in the ICU are in a stable condition. On the second postoperative day of care, the patient was transferred to the High care ward, then at the third postoperative day the patient's hemodynamics was stable and the patient was transferred to a normal room.
Kepuasan kerja sebagai mediasi efek locus of control terhadap kedisiplinan karyawan
Authors: Kurniawati Eka , Sarwoko Endi , Andayani Endah
Published: November 2021

The aim of the study was to investigate the effect of locus of control on employee discipline and the role of job satisfaction in mediating the relationship of locus of control on employee discipline. This study uses a quantitative approach, the research was conducted at YPI Miftahul Huda Papar, Kediri Regency, data was collected using a questionnaire filled out by all employees. Locus of control is measured by the ability, interest, effort, fate, and influence of others. Job satisfaction is measured by using 2 factors motivation, the last work discipline includes goals, justice, inherent supervision, sanctions and punishments. Data were analyzed for hypothesis testing using Path Analysis. The results of the analysis reveal that locus of control and job satisfaction have an effect on employee discipline. Another finding is that job satisfaction plays a role in mediating the influence of locus of control on work discipline. Suggestions for further research is to develop this research in a different place and examine the consequences of work discipline.
Making the Computation of Approximations of Invariant Measures and Its Attractors for IFS and GIFS, Through the Deterministic Algorithm, Tractable
Authors: Cunha Rudnei Dias da , Oliveira Elismar R.
Published: November 2021

We present algorithms to compute approximations of invariant measures and its attractors for IFS and GIFS, using the deterministic algorithm in a tractable way, with code optimization strategies and use of data structures and search algorithms. The results show that these algorithms allow the use of these (G)IFS in a reasonable running time.
Explore Upper Limits of Bone Mineral Content And Density In Humans: A Study On Japanese Collegiate Sumo Wrestlers
Authors: Midorikawa Taishi , Torii Suguru , Ohta Megumi , Sakamoto Shizuo
Published: November 2021

The purpose of this study was to explore the upper limit of total bone mineral content (BMC, kg) and bone mineral density (BMD, g/cm2) in humans by estimating body composition of Sumo wrestlers. A total of 54 male college Sumo wrestlers were recruited for the study and assigned to 2 groups according to body weight (middleweight, 85-115 kg, n = 23 and heavyweight, >115 kg, n = 31). BMC, BMD, fat mass and lean soft tissue mass (LSTM) were measured using dual-energy X-ray absorptiometry (DXA) for the total and appendicular regions. Heavyweight Sumo wrestlers had significantly greater body weight, fat mass, and LSTM compared to middleweight Sumo wrestlers. Mean total BMC was significantly larger in heavyweight than middleweight Sumo wrestlers, respectively (The highest value was 4.16 kg.). Total BMD was significantly higher in heavyweight compared to middleweight Sumo wrestlers (The highest value was 1.59 g/cm2.), and was significantly correlated with body weight, but not with fat mass and LSTM. Based on the present and previous studies, the upper limit of total BMC and BMD in humans with 150 kg bodyweight might be around 5.0 kg and 1.60 g/cm2.
LaCl3 Treatment Improves the Agrobacterium-mediated Immature Embryo Genetic Transformation Efficiency in Maize
Authors: Liu Shengnan , Shi Yunlu , Guo Yan , Lu minhui
Published: November 2021

Agrobacterium

mediated genetic transformation of immature embryo plays an important auxiliary role in the study of gene function and molecular breeding in maize. However, the relatively low genetic transformation efficiency is still the bottleneck of the application of this method, especially in commercial scale production application. In this study, we found that pretreatment of immature embryos with LaCl 3 , a Ca 2+ channel blocker, could improve the infection efficiency of Agrobacterium tumefaciens , increase the proportion of resistant calluses, obtain more positive regenerated plantlets, and finally improve the transformation efficiency in maize. This optimization provides a new direction for improving the efficiency of plant genetic transformation mediated by Agrobacterium tumefaciens .
Hyoscyamus labiatus sp. nov. (Solanaceae: Hyoscyameae) from Henan, China: implications for the delimitation of Hyoscyamus
Authors: Liu Yan-Yan , Wang Qi-Rui , Mi Zeng-Lu , Li Jia-Mei
Published: November 2021

Background

Hyoscyamus, the largest genus in the tribe Hyoscyameae, harbors more than 20 species. Although the monophyly of Hyoscyamus is supported by both morphological and molecular phylogenetic studies, the delimitation of Hyoscyamus has been hotly debated in different classifications. Here, we report a new species of Hyoscyamus (Solanaceae) from Henan Province, China, and discuss the delimitation of Hyoscyamus.
Results

This species is morphologically similar to the known species of Hyoscyamus and its close related genus Archihyoscyamus, but can be distinguished by corolla 2-lipped, adaxial lip 3-lobed and much longer than abaxial lips, tube slender at base, and stamens 5, inserted on inner side of disk, free, obviously unequal, and exceeding corolla. Phylogenetic analysis based on four chloroplast markers including rbcL, ndhF, trnC-psbM and trnL-trnF, strongly suggested that the new species was sister to a monophyletic group containing all species of Hyoscyamus and Archihyoscyamus previously described.
Conclusions

Both the morphological observations and molecular phylogenetic analyses support the recognition of Hyoscyamus labiatus as a new species. Our study also showed that Archihyoscyamus should be a synonym of Hyoscyamus. The delimitation of Hyoscyamus is thus revised in our study.
Research on the Dynamic Response of Frame Structure under the Explosion Load of Acetylene-Air Mixture
Authors: Gao Jun , Zhang Xin , Liu Jiheng
Published: November 2021

Explosion is the act of generating huge energy in an instant and spreading rapidly around it. Due to the suddenness, fast propagation speed and high peak load of explosions, compared with other natural disasters, the damage it brings to humans is more significant and difficult to prevent. Among them, the explosion of acetylene-air mixture is the most typical explosion problem. This paper uses SAP2000 finite element software to perform a fine simulation of actual explosion events, studies the effect of the explosion of acetylene-air mixture on the frame structure column, and discusses the displacement and acceleration changes of various components. Research shows that the use of the principle of linear assumption of explosive load can effectively simulate the actual explosion situation. The structural damage and deformation caused by the explosive load have locality and weak transmission. When the peak of the explosion load is larger, the structure deformation is greater, and the impact of the explosion load on the structure is isotropic.
Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblast Derived from Umbilical Cord Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial
Authors: Won Heejae , Kim Shin-Yoon , Lee Sunray , Park Hyun Sook , Baek Seung-Hoon
Published: November 2021

BackgroundVarious techniques for joint preservation have been attempted in early stage of osteonecrosis of femoral head (ONFH), but the effects are still controversial. Recently, a combination therapy of core decompression (CD) and MSCs collected from bone marrow, adipocytes or human umbilical cord has been introduced, and satisfactory results have been reported. However, there is no study in which human umbilical cord-derived osteoblasts (hUC-O) were administered directly to the lesion in early ONFH. We have classified the location and size of lesions in early-stage ONFH, and will evaluate the hypothesis that the application of hUC-O is a safe and effective treatment.MethodsThis is a prospective, single-center, phase I and open-labeled clinical trial. Nine patients with Association Research Circulation Osseous (ARCO) stage 1 or 2 ONFH will be assigned to a low-dose (n = 3, 1 ´ 107 hUC-O cells), medium-dose (n = 3, 2 ´ 107 cells), and high-dose group (n = 3, 4 ´ 107 cells) in the order of their arrival at the facility, and up to 18 patients will be enrolled depending on whether dose limiting toxicity occurs. We will perform CD on the participants, administer hUC-O according to the assigned group, and followed up for 12 weeks, including a total of 5 visits. This study will have 3 aims; first, to evaluate the safety of hUC-O through adverse events assessment, laboratory tests, vital sign assessment, physical examination, and electrocardiogram (ECG) test.; and second, to assess the clinical outcomes after hUC-O application by comparing pain visual analog scale (VAS), Harris Hip scores (HHS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) before and after surgery; and third, to evaluate the radiographic results after hUC-O application by comparing extent of necrotic lesions according to the ARCO and Japanese Investigation Committee (JIC) classification on magnetic resonance imaging.DiscussionThis clinical trial is a pilot phase 1 study evaluating the safety and efficacy of hUC-O local application combined with CD in early-stage ONFH patients. This study will provide the useful information on the treatment with hUC-O for those suffering from ONFH.Trial registration: Clinical Research Information Center (CRIS) established at the Korea Centers for Disease Control and Prevention (KDCA), KCT0006627. Registered 30 September 2021, https://cris.nih.go.kr/cris/search/detailSearch.do/20332
Emergence of Autoimmune Type 1 Diabetes and Acute Adrenal Crisis Following COVID-19
Authors: Oğuz Seda Hanife , Gürlek Alper
Published: November 2021

Objective: Several case reports have indicated a possible link between Coronavirus Disease 2019 (COVID-19) and new-onset autoimmune disorders while co-precipitation of autoimmune type 1 diabetes and Addison’s disease has never been reported to date. Case Description: A 60-year-old male presented with extreme fatigue and weight loss three weeks after testing positive for COVID-19. The course of COVID-19 was mild, without pulmonary involvement. The patient showed symptoms and laboratory signs of new-onset diabetes without ketoacidosis and acute primary adrenal insufficiency, latter of which was confirmed with an ACTH stimulation test. GAD-65 antibody and antibodies to the adrenal cortex were positive in high titers, and the patient also had primary hypothyroidism associated with autoimmune thyroiditis. Previous medical records of the patient revealed no hyperglycemia or electrolyte abnormalities prior to current admission, but an earlier test result compatible with primary hypothyroidism. The patient was diagnosed with autoimmune polyglandular syndrome type II (APS II). Clinical and laboratory findings improved after starting appropriate hormone replacement therapies along with insulin. Conclusions: Evidence mostly obtained from case reports suggests that COVID-19 may induce a variety of autoimmune disorders in susceptible subjects. In our case, COVID-19 might have simply precipitated T1D and adrenal crisis in whom autoimmune thyroiditis may have been the first manifestation of an undiagnosed APS II. Or, COVID-19 may have triggered autoimmunity in the patient who was possibly predisposed to autoimmune disorders, and led to the development of APS II. Anyhow, more research is required to evaluate the possible link between COVID-19 and autoimmune disorders.
Different Stand types Alter Soil Properties and Microbial Community in Warm Temperate Forest
Authors: SHI Ce , WEI Yi-fan , ZHU Lin , ZHANG Run-zhe , YANG Hao , NIE Hao-liang , WANG Jiang , BO Hui-juan , NIE Li-shui
Published: November 2021

Soil microorganism play an important role in maintaining the structure and function in warm temperate forest ecosystem. In order to explore the characteristics of soil microbial community under different stand types in in warm temperate zone, Illunima Miseq High-throughput Sequencing was used to assess the soil bacteria (16S rRNA) and fungi (ITS rRNA) communities of five forest stands (Pinus tabulaeformis [PT], Juglans mandshurica [JM], Betula platyphylla [BP], Betula dahurica [BD] and Quercus mongolica [QM]) in Songshan Nature Reserve. The results showed that the bacterial diversity under Juglans mandshurica forest was higher than other types, the fungal diversity under Pinus tabulaeformis forest was higher than other types. The dominant phyla and gene of soil bacteria were similar in different stand types, but there were significant differences in abundance and dominant gene of fungal community. VPA analysis showed that soil explained 49.1% of the variance in bacterial community composition and 70.6% of the variance in fungal community composition. RDA analysis showed that the dominant phyla were significantly correlated with soil pH, SOM, TN and AN. Based on our results, there are significant differences in soil microbial community structure among different stand types. Consequently, our results have important implications for understanding the driving mechanisms that control the soil microbial community during warm temperate forest.
Individual Differences in Concurrent Developmental Trajectories of Pain and Insomnia in Adolescents Are Predicted by Chronotype and Arousal-causing Pre-sleep Behaviors.
Authors: Arnison Tor , Schrooten Martien G. S. , Bauducco Serena , Jansson-Fröjmark Markus , Persson Jonas
Published: November 2021

The onset of both chronic pain and insomnia is high during adolescence. Although a bidirectional relationship between pain and insomnia has support, how pain and sleep co-develop throughout adolescence remains unknown. Both sleep-wake patterns and pre-sleep behaviors that cause arousal may influence the co-development of pain and insomnia. Four waves of longitudinal self-report data were used (Nbaseline = 2767, Agebaseline M = 13.65 years, SD = 0.65). Multidimensional growth mixture modeling was used to identify four subgroups of adolescents with different concurrent trajectories of pain and insomnia. The trajectories followed each other across time in all classes: one class of consistently low pain and insomnia (68.7 %), one class with persistent high symptoms (4.9 %), as well as one class of increasing (13.9 %), and one of decreasing (12.5 %), trajectories. Later sleep-wake patterns and more pre-sleep behaviors causing cognitive-emotional arousal predicted both increasing and decreasing trajectories of concurrent pain and insomnia. The current study showed that developmental trajectories of pain and insomnia follow each other within adolescents and across adolescence. Both sleep-phase focused interventions as well as psychological interventions that focus on pre-sleep behaviors causing cognitive-emotional arousal may prove beneficial for adolescents with comorbid pain and insomnia.
Association of RAS mutations with early progression after first-line systemic therapy in patients with initially unresectable colorectal cancer liver metastasis
Authors: Cao Di , Li Cong , Zhou Chi , Zhang Weili , Lu Zhenhai , Pan Zhizhong , Chen Gong , Peng Jianhong
Published: November 2021

Purpose

Patients with initially unresectable colorectal cancer with liver metastases (IU-CRLM) need to undergo first-line systemic therapy with the aid of chemotherapy. However, the driver gene attributed to early progression in IU-CRLM patients after first-line systemic therapy remains unclear. Our study explored the RAS mutation status related to early progression in IU-CRLM patients.
Methods

A total of 193 IU-CRLM patients with RAS status detection were retrospectively enrolled from December 2012 to January 2020. We defined early progression as tumour progression within 6 months after first-line systemic therapy. Univariate and multivariate logistic regression for early progression were implemented to identify the risk factors.
Results

RAS mutations were found in 51 (26.0%) IU-CRLM patients. A total of 107 (55.4%) patients were confirmed to have early progression after first-line systemic therapy. RAS mutation was significantly related to early disease progression (66.7% vs. 49.3%, P=0.033). Logistic analysis results showed that RAS mutation (OR=2.962, 95% CI 1.354-6.478, P=0.007) was an independent risk factor for early disease progression.
Conclusions

Mutated RAS was an important risk factor for early progression in IU-CRLM patients after first-line systemic therapy.
A semi-randomized study determining the psychological and physical effects of three types of eye masks on adult women
Authors: Murota Masako , Isoda Kazuko , Takahira Yuka , Kurahashi Tomiko , Tanaka Kanako , Sugimori Atuko , Yamamoto Yoko , Iwawaki Yoko
Published: November 2021

Background: Warm compresses are one of the nursing techniques clinically used to improve patients’ comfort and promote the treatment efficacy. Here the effects of eye masks (EM), heated eye masks (HEM), and aroma-scented heated eye masks (AHEM) and their potential as a nursing technique to provide comfort were studied.Methods: Participants in this study were 42 healthcare professionals (female, 20–60 years of age), who voluntarily consented to participate. They participated in all three interventions with EM, HEM, and AHEM at an interval of at least 1 week between interventions. Indicators used were low frequency to high frequency ratio (LF/HF), blood flow, axillary temperature, pulse rate, blood pressure, the salivary α-amylase activity (SAA), and the Profile of Mood States Second Edition (POMS).Results: Of 42 participants in total, 32 were included in the analysis. Their mean age was 46.8 years. The blood flow and axillary temperature values significantly increased and the LF/HF values and the pulse rates significantly decreased after the use of EM, HEM, or AHEM. The POMS Total Mood Disturbance (TMD) score and scores for six POMS subscales significantly decreased after the use of EM, HEM, or AHEM.Comparisons among the three groups showed differences in LF/HF. Scores for subscales of POMS also differed among the three groups.Conclusions: These results suggest that the use of EM, HEM, or AHEM intervention is safe with no major body burden. Parasympathetic nerves may be dominant after the EM, HEM, or AHEM interventions The TMD score improved after the EM, HEM, or AHEM intervention. The data suggest that the AHEM use is particularly effective in alleviating depression, dejection, and confusion after the intervention. These findings indicates that the EM, HEM, or AHEM use holds potential as a nursing technique to provide comfort.Trial registration: UMIN Clinical Trials Registry (UMIN000018409Trial registration number: UMIN-CTR R000021207Date of registration: 07/24/2015
As Antimicrobial Agents: Synthesis, Structural Characterization and Molecular Docking study of Barbituric Acid Derivatives from Phenobarbital
Authors: Fahad Mahmood M. , Shafiq Nusrat , Arshad Uzma , Radh Ali Jabbar
Published: November 2021

In spite of phenobarbital has been used in various medical fields as hypnotics, anxiolytics, and anticonvulsants, it also contains active functional groups that can be reacted to form other products as dyes, polymers, antimicrobial and anti-antioxidants agents. A series of barbituric acid derivatives containing 1,2,3,4-Tetrazoline moiety were synthesized from phenobarbital. Phenobarbital 1 as raw starting material was reacted with acrylonitrile compound to give diacetonitrile derivative 2, this compound was treated in two ways, urea and thiourea to form barbituric acid derivatives containing oxadiazole and thiadiazole ring 3, 4 respectively. The Schiff bases derivatives 5, 6 (a-c) were synthesized from reacting the latter compounds with three aromatic aldehydes. In the final step, the barbituric acid derivatives containing 1,2,3,4Tetrazoline moiety 7, 8 (a-c) were prepared by cycloaddition reaction between different Schiff bases derivatives and sodium azide. The compounds were characterized by Melting point, 13 C-NMR, 1 H-NMR and FTIR techniques. Also, the result compounds were tested against two kinds of bacteria and two kinds of fungi. Most of the prepared derivatives were showed a high and clear effect against different types of bacteria and fungi. Molecular docking of final barbituric acid derivatives 7, 8 (a, b) were investigated with Molegro Virtual Docker (MVD).
Ghrelin, Growth Hormone, and Insulin-like Growth Factor-I Levels in People With Protein C Deficiency
Authors: Dons-Jensen Anna , Horup Sascha Siig , Hvas Anne-Mette , Vestergaard Esben Thyssen , Johansen Rakel Fuglsang
Published: November 2021

The authors have requested that this preprint be removed from Research Square.
Adiponectin Is Negatively Associated With Disease Activity and Sharp Score in Rheumatoid Arthritis: a Cross-sectional Study on Treatment-naïve Han Chinese Patients
Authors: Chen Xixi , Wang Kaiwen , Lu Tao , Wang Jiajia , Zhou Ting , Tian Juan , Zhou Bin , Long Li , Zhou Qiao
Published: November 2021

Background: The association and potential role of the protein hormone adiponectin in autoimmune diseases causing musculoskeletal disorders, including rheumatoid arthritis (RA), are controversial. Conflicting results may arise from the influences of confounding factors linked to genetic backgrounds, disease stage, disease-modifying anti-rheumatic drugs and patients’ metabolic characteristics. Here, we examined serum level of adiponectin and its relationship with disease activity score 28 with erythrocytes sedimentation rate (DAS28[ESR]) and Sharp score in a treatment-naïve Han Chinese RA population.Methods: This cross-sectional study enrolled 125 RA patients. Serum level of total adiponectin was assessed by enzyme-linked immunosorbent assay (ELISA). Other important clinical and laboratory parameters were collected from the hospital database. DAS28(ESR) was calculated according to the equation previously published. Sharp score was evaluated based on hands radiographs by an independent radiologist. The correlation between serum adiponectin level and DAS28(ESR) or the Sharp score was investigated by univariable and multivariable regression analyses. Multiple imputation by chained equations was used to account for missing data.Results: Univariable analyses showed significant positive correlation between DAS28(ESR) and age or C-Reactive Protein (CRP) (both p = 0.003), while serum adiponectin level was negatively correlated with DAS28(ESR) (p = 0.015). The negative correlation between adiponectin level and DAS28(ESR) remained true in multivariable analyses adjusted for confounders. In addition, the univariable analyses revealed positively correlations of Sharp score to disease duration (p < 0.001), CRP (p = 0.023) and ESR (p < 0.001). In the multivariable model adjusted for confounders, adiponectin was negatively correlated with Sharp score (p = 0.044).Conclusion: In this single-institution cross-sectional study, serum adiponectin level in treatment-naive RA patients is negatively correlated with DAS28(ESR) and the Sharp score after adjustment for prominent identified confounders. Serum adiponectin may be potentially useful for assessing disease activity and radiographic progression of RA.
Renewable Energy Demand, Financial Reforms and Environmental Quality in West Africa
Authors: Obuobi Bright , Zhang Yifeng , Nketiah Emmanuel , Adu-Gyamfi Gibbson , Cudjoe Dan
Published: November 2021

Sustainable Development Goal (SDG-7) stipulates the need for clean energy, reduced carbon emissions, prevention of environmental degradation, promotion of biodiversity, and ecosystem preservation. Towards achieving these goals, this study provides new evidence on the causal link between renewable energy demand, financial reforms, economic growth, foreign direct investment, and environmental quality among emerging West African economies. The study adopted the Fully Modified Ordinary Least Squares, Dynamic Ordinary Least Squares, Pooled Mean group estimation and Granger causality test for its analysis. It was found that renewable energy demand has been favorable to the environmental health of West African economies. Also, financial reforms made within the region contributed to increasing the ecological footprints of the region. Direct investments from foreign companies showed encouraging results as it improves the environment quality. We also found a unidirectional causality from ecological footprints to renewable energy demand and financial reforms but a bidirectional relationship with economic growth and foreign direct investment. Moreover, it was evident that ecological footprints granger causes financial reforms and economic growth but not vice versa. Policy recommendations outlined encourages governments and policy-makers to embark on intensive clean energy technologies and effective green financial reforms to help achieve Sustainable Development Goals.
Polypyrrole Induced By Carbon Nanotube To Form Mutiple-Strand Helix
Authors: Gong Wendi , Zhang Danhui , Liang Ruquan , Zhang Dengbo , Liang Shiming , Liu Anmin
Published: November 2021

In this manuscript, a molecular dynamics simulation is used to study the formation of multiple-strand helix through polypyrrole induced by carbon nanotube. The results exhibit that the multiple polypyrrole chains arranged in parallel can self-assemble to helix. The formation machenisum is also illustrated in detail. The formation process may experience two stages which are insertion and torsion. Both the van der Waals potential well and the π–π stacking interaction among the multiple polypyrrole and carbon nanotube play a major role in the self-assemble process. Furthermore, a lot of factors such as the chain number of polypyrrole, the length of polymer and the simulation temperature influence the final configuration of composite. This theory research can provide valuable theoretical support for design and manufacture hybrid structures in the fields of advanced composite materials and functional devices.
Clinical Efficacy of Radiotherapy Combined with Surgery for Locally Advanced Gastric Signet-Ring-Cell Carcinoma: A SEER Database Analysis
Authors: Lin Xiaohan , Chen Biyu , Zheng Wei , Yang Shugang , Zhu Guangwei , Wang Jinzhou , Huang Yongjian , Ye Jianxin
Published: November 2021

Background: The objective of this study was to assess the clinical efficacy of radiotherapy combined with surgery for locally advanced gastric signet-ring-cell carcinoma (GSRCC). Methods: Clinical data of patients with locally advanced GSRCC diagnosed by postoperative pathology from 2000-2016 were collected from the US Surveillance, Epidemiology and End Results (SEER) database. All the enrolled patients were divided into three groups according to treatment type: surgery alone (S; N=727), surgery with preoperative radiotherapy (RT+S; N=138), surgery with postoperative radiotherapy (S+RT; N=548). Results: The median overall survival (OS) time in S, RT+S and S+RT group was 19, 26 and 33 months, respectively; the overall survival (OS) rate was 19.5%, 26.9% and 34.0%, respectively; the median cancer-specific survival (CSS) time was 29, 31 and 43 months, respectively; and the CSS rate was 32,4%, 35.3% and 43.6%, respectively. After performing propensity score matching (PSM), it was found that the OS rate was significantly lower in S group than in RT+S or S+RT group (all P<0.05) and the CSS rate was lower in the SA group than in the S+RT group (P<0.0001) while there was no significant difference between S and RT+S groups. The OS and CSS were not significantly different between RT+S and S+RT groups. Cox multivariate analysis showed that radiotherapy was an independent prognostic factor for OS and CSS of locally advanced GSRCC.Conclusions: Compared to surgery alone, surgery combined with preoperative or postoperative radiotherapy is beneficial to the long-term survival of patients with locally advanced GSRCC.
High-Flow Nasal Cannula and Prone Positioning in Awake Patients with COVID-19 Related Respiratory Failure: An Observational Study.
Authors: Abroug Fekri , Hammouda Zeineb , Lahmar Manel , Nouira Wiem , Maatouk Syrine , Youssef Sourour Belhaj , Dachraoui Fahmi , Ouanes-Besbes Lamia
Published: November 2021

Background: We report an observational study on the use of High-flow nasal cannula (HFNC) and awake prone position in patients with Covid-19 related severe ARF.Methods: chart analysis of consecutive patients with confirmed Covid-19 and severe ARF (PaO2/FiO2 ratio <150) who received HFNC. Patients were systematically encouraged to lie in the prone position if tolerated. We calculated initial ROX index (the ratio of SpO2/FIO2 to respiratory rate) while in supine position and at the end of the first HFNC session whether in prone or supine position, and their difference (delta ROX). The success/failure of HFNC (need for intubation) was recorded. Predictors of HFNC failure were identified using ROC curve and logistic regression.Results: HFNC was administered to 213 out of 360 patients with COVID-19 related severe ARF (71% male, median age:59 years (IQR:50-68), median PaO2/FIO2: 104(73-143). At the start of HFNC, median ROX index was 4(3.4-5). Among included patients, 178 (83.5%) could tolerate prone position and had a median of 4.4(2-6) prone sessions during a median of 10(4-16) hours/day each, for a median of 4(2-7) days. Overall, HFNC failure occurred in 61 patients (28.1%) with similar proportions in patients who had HFNC in prone position and in patients who did not tolerate prone position (29% and 26%, respectively; relative risk:1.14. 95%CI:0.62-2.1). In the prediction of HFNC outcome, AUC was highest for delta ROX (AUC=0.83); AUC for baseline ROX (0.71), PaO2/FiO2 (0.73), and SpO2 (0.67), were significantly lower. The delta ROX cut-off ≤1.8 had the best Youden index indicating the best combination of sensitivity (0.89) and specificity (0.61) with a PLR (2.33) and a NLR (0.17) to predict HFNC failure. Logistic regression disclosed the following predictors of HFNC failure: delta ROX: RR=0.44, 95%CI=0.32-0.62; p-0.0001); baseline ROX index: RR=0.58, 95% CI:0.39-0.85, p=0.005); SOFA score (RR=1.6 for each point; 95%CI: 1.1-2.2, p=0.007); and PaO2/FiO2 at admission: RR=0.96, 95%CI=0.94-0.99). Prone position was not related to HFNC success.CONCLUSION: Awake HFNC in prone position is feasible in most patients with severe hypoxemic COVID-19. Indicators of ARF severity and the early response to HFNC, rather than prone position are independently associated with HFNC outcome.
Analyzing and prediction of rainfall trends over Baghdad city
Authors: Khtan Asraa , Al-ATABI Iqbal Khalaf
Published: November 2021

Rainfall is a key part of the hydrological cycle and alteration of its pattern directly affects the water resources. The changing pattern of rainfall in consequence of climate change is now concerning issues to water resource managers and hydrologists. The present study aims to analyze the trend and forecast annual rainfall in Baghdad. rainfall data for the period of 1979-2019 was analyzed in this study, Statistical trend analysis techniques namely linear and Exponential trend were used to examine and analyze the problem. The result shows that rainfall will decrease in both methods but the liner method gives a higher value. from plotting time series of annual rainfall see that very variation so 5- moving average made to reduce the variance of rain but still variations so second 5- moving average made give less variance for rain then teak liner trend the result show also trend will decrease but reach 125 mm less than liner trend of actual series.
Focused Ultrasound Neuromodulation On A Multiwell MEA
Authors: Saccher Marta , Kawasaki Shinnosuke , Onori Martina Proietti , Woerden Geeske van , Giagka Vasiliki , Dekker Ronald
Published: November 2021

Background: Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation methods will greatly enhance the application range of MEAs to study their effects on neurons. A neuromodulation method that is recently gaining more attention is focused ultrasound neuromodulation (FUS), which has the potential to treat neurological disorders reversibly and precisely. Methods: In this work, we present the integration of a focused ultrasound delivery system with a multi-well MEA plate. Results: The ultrasound delivery system was characterised by ultrasound pressure measurements, and the integration with the MEA plate was modelled with finite-element simulations of acoustic field parameters. The results of the simulations were validated with experimental visualisation of the ultrasound field with Schlieren imaging. In addition, the system was tested on a murine primary hippocampal neuron culture, showing that ultrasound can influence the activity of the neurons. Conclusions: Our system was demonstrated to be suitable for studying the effect of focused ultrasound on neuronal cultures. The system allows reproducible experiments across the wells due to its robustness and simplicity of operation.
Human Adipose Mesenchymal Stem Cells Modulate Inflammation and Angiogenesis Through Exosomes
Authors: Heo June Seok , Kim Sinyoung
Published: November 2021

Stem cell-derived exosomes are efficient and safe therapeutic tools for transferring endogenous biological cargo or functional biomolecules for regenerative medicine. The regulation of inflammation and angiogenesis plays a pivotal role in wound healing and tissue regeneration. The purpose of this study was to investigate the anti-inflammatory and pro-angiogenic roles of human adipose mesenchymal stem cell-derived exosomes, focusing on the underlying mechanisms. Exosomes inhibited LPS-induced inflammation by activating ROCK1 and PTEN expression. Moreover, microRNAs (miR-132 and miR-146a) released from exosomes upregulated the expression of pro-angiogenic genes and promoted proliferation activity and tube formation in human umbilical vein endothelial cells. Exosomal effects were verified using ROCK1/PTEN inhibitors for anti-inflammation and miR-132/miR-146a inhibitors for pro-angiogenesis. Our findings suggest that exosomes exert anti-inflammatory effects by targeting the ROCK1/PTEN pathway and exhibit pro-angiogenic effects via delivery of miR-132 and miR-146a. Taken together, these results suggest that exosomes may be promising therapeutic candidates for curing diseases involved in inflammation and angiogenesis.
RainCast: A Rapid Update Rainfall Forecasting System for New Zealand
Authors: Zhang Sijin , Barrow Gerard , Soltanzadeh Iman , Rye Graham , Zhan Yizhe , Webster Chris , Noble Chris
Published: November 2021

RainCast is a rapid update forecasting system that has been developed to improve short-range rainfall forecasting in New Zealand. This system blends extrapolated nowcast information with multiple forecasts from numerical weather prediction (NWP) models to generate updated rain forecasts every hour. It is demonstrated that RainCast is able to outperform the rainfall forecasts produced from NWP systems out to 24 hours, with the greatest improvement in the first 3-4 hours. The limitations of RainCast are also discussed, along with recommendations on how to further improve the system.
The Influence of Acetabular Morphologic Variations on the Cup Position in Total Hip Arthroplasty for Crowe type III Dysplastic Hip
Authors: Shen Junmin , Zhang Ti , Dong Yu , Zhang Yanchao , Zhou Yonggang , Guo Lingfei
Published: November 2021

Background: We aimed to (1) evaluate the acetabular morphologic variations of Crowe III hips; (2) study the influence of different morphologies on the cup position in total hip arthroplasty.Methods: From November 2008 to February 2019, we retrospectively evaluated 101 patients (110 hips) with Crowe III developmental dysplasia of the hip. We classified Crowe III hips into two subtypes, the IIIA when the acetabular roof was extensively deficient and the junction between the false and the true acetabulum was indistinct, and the IIIB when there is a significant crest between the false and the true acetabulum. Based on the radiographs, we measured the morphological characteristic of the acetabulum and the postoperative cup position.Results: The false acetabulum of IIIB hips had larger Tonnis angle and smaller center-edge angle than the IIIA hips. The width of true acetabular roof in the IIIB hips was thicker than the IIIA group. Fifty-one (100%) IIIA hips and 48 (81.4%) IIIB hips were reconstructed using high hip center while 11 (18.6%) IIIB hips were reconstructed anatomically. The mean vertical distance of center of rotation in the IIIA group was 33.5±4.5 mm while it was 31.2±6.3 mm in the IIIB group (p=0.040). The vertical distance of the hip center was positively correlated with the height of dislocation in the IIIA group (r=0.493, p<0.001). According to the four-zone system, in the IIIA group, 5 hips were located in the inferomedial zone, 23 hips in the superomedial zone, 22 hips in the superolateral zone and 1 hip in the inferolateral zone. In the IIIB group, the corresponding numbers were respectively 15, 17, 1 and 5. Compared with the IIIA group, there were more IIIB hips located in the inferomedial zone (p=0.008) and less in the superolateral zone (p=0.033).Conclusions: There are distinct morphologic subtypes based on the relationship between the false and the true acetabulum. More bone stock located in the superior wall of the true acetabulum can bring more possibilities for anatomical reconstruction, and lower the height of center of rotation when using high hip center.
Improved Artificial Neural Network Grid Synchronization Technique for Three-Phase Grid Systems based on Synthesis Segmental Multilevel Converter
Authors: Rajendran Nirmala , Sundharajan Venkatesan
Published: November 2021

The solar Photovoltaic (PV) systems have gained a significant attention due to its easy implementation and availability. In which, the proper energy management should be mainly concentrated for a successful PV power utilization. In the traditional works, various controlling techniques have been developed for reactive power compensation. But, it lacks with the issues related to reduced system performance, increased loss, and high harmonics. To solve these issues, this paper aims to develop a new controlling methodology, named as Synthesis Segmental Multilevel Converter (SSMC) for reactive power compensation in a three phase grid systems. Initially, it extracts the maximum power from the solar PV systems by using an Enhanced Perturb and Observe (EPO) method. The panel separation is done and the three phase power input is given to the SSMC converter, where the synchronization and switching pulse generation processes are performed. During synchronization, integrated techniques such as Proportional Integral (PI), Fuzzy Logic Controller (FLC), and Improved Artificial Neural Network (IANN) techniques are utilized to maintain the voltage, magnitude and phase angle in a same level. Consequently, the Inductance Capacitance (LC) filtering technique is applied to reduce the harmonics distortion in the signal. After that, the Park transformation is used to perform the dq0 to abc transformation, which is implemented for reducing the high volume of error. Finally, the error free signal is fed to the three phase grid system with reduced harmonics also both the simulation and analytical results have been taken for analyzing the performance of the proposed technique.
Task Optimization Leads to Human-like Top-down and Bottom-up Attention during Reading Comprehension
Authors: Zou Jiajie , Ding Nai
Published: November 2021

Attention is a complex system involving multiple interactive components that jointly regulate information processing in the brain. It has been hypothesized that the computational goal of attention is to optimally integrate information under task demands, and evidence has been provided in relatively simple learning and decision making tasks. It remains unclear, however, whether this hypothesis can explain attention distribution in more complex real-world tasks that engage multiple attention systems. Here, taking advantage of the development of attention mechanisms in deep neural network (DNN) models, we investigate whether human attention during real-world reading comprehension tasks can be explained as a consequence of task optimization. In a goal-directed reading task, participants read a passage to answer a question. Eye tracking results show that the attention on each word, quantified by the fixation time, is modulated by both the top-down reading goal and lower-level visual layout and textual features. When trained to perform the same goal-directed reading task, DNN models yield human-level performance and naturally evolve human-like attention distribution, with deep layers tuned to the reading goal and shallow layers tuned to textual features. Further experiments suggest that different training tasks separately contribute to goal-directed and text-based attention. In summary, the results strongly suggest that human attention can be interpreted as a consequence of task optimization during real-world reading tasks.
The New Phi Function and some of it's Applications
Authors: Das Prithwis
Published: November 2021

In Mathematics, we see a large number of functions, each having its own properties. Some of these are very interesting and contribute greatly to the intensive research in the field of Mathematics. This paper deals with one such function (which we have termed as the phi function) which emerges from a chain of inequalities, established from the basic concepts of differential calculus. This paper establishes several inequalities which relate to functions and their integrals. Another important expression (from the point of view of notations) links a class of divergent infinite series to the phi function. Finally, we will dive into a brief overview of the phi-form of plane trigonometric functions and derive the trigonometric identity sin2(θ) + cos2(θ) = 1, thus marking their importance. Throughout the paper, we will be analyzing functions in R+ such that the functions are always greater than 0. We will also consider that the functions are continuous and differentiable in the intervals under consideration.
A Comprehensive Study of Large Negative Dispersion and Highly Nonlinear Perforated Core PCF: Theoretical Insight
Authors: Upadhyay Anurag , Singh Shivam , Sharma Divya , Taya Sofyan A
Published: November 2021

A novel photonic crystal fiber (PCF) containing circularly organized square-shaped air holes in the cladding region is investigated. The fiber core is perforated with four circular air-filled holes to instate high nonlinearity and large negative dispersion. The numerical analysis is done with a finite element method based COMSOL Multiphysics tool to investigate different optical properties of the propounded PCF. Simulation outcome verifies a high nonlinear coefficient value of 300 W-1 Km-1 which is the highest ever achieved value without using any nonlinear materials or liquids to the best of our knowledge. In parallel, a maximum negative chromatic dispersion of -1689 ps/nm/km is achieved. Moreover, birefringence, numerical aperture, and propagation loss are also measured as 2.40×10-3, 0.59, and 4.12×10-11 dB/m respectively along with an extremely high core power fraction of 99.98%. Hence, the propounded PCF is suitable for residual dispersion compensation, supercontinuum generation, and high bitrate transmission.
The Correlation between IgM and IgG Antibodies with Blood Profile in Patients Infected with COVID 19
Authors: Alibolandi Zahra , Ostadian Amirreza , Sayyah Saeed , Kashani Hamed Haddad , Ehteram Hassan , Banafshe Hamid Reza , Hajijafari Mohammad , Sepehrnejad Mahdi , Kashani Narjes Riahi , Azadchehr Mohammd-Javad , Nikzad Hossein , Hosseini Elahe Seyed
Published: November 2021

Objectives: This study aimed to determine the levels of IgM and IgG antibody response to the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with different disease severity.Methods: IgM and IgG antibody levels were evaluated via enzyme-linked immunosorbent assay (ELISA). In total, 100 patients with confirmed SARS-CoV-2 infection were enrolled in this study and viral RNA was detected by using Real-time PCR technique. Clinical and laboratory data were collected and analyzed after hospital admission for COVID-19 and two months post-admission. Results: The level of anti-SARS-CoV-2 antibody IgG was significantly higher in the severe patients than those in moderate and mild groups, 2 months after admission. Also, level of IgG was positively associated with increased WBC, NUT and LYM counts in sever than mild or moderate groups after admission to hospital.Conclusion: Our findings suggested that patients with severe illness might experience longer virus exposure times and have a stronger antibody response against viral infection. Thus, they have longer time immunity compared with other groups.
BcMF27 , a Pectin Methylesterase Gene, Regulates Pollen Development And Pollen Tube Growth in Brassica Campestris
Authors: Yue Xiaoyan , Cao Jiashu
Published: November 2021

Functional pollen grains are an essential ingredient of successful reproduction in flowering plants and are protected by outer walls. Pectin methylesterases (PMEs) modify pectin, a structural component of pollen intine. However, there are few studies on PMEs. Artificial microRNA (amiRNA) and overexpression technology was performed to investigate the function of pollen-specific PME gene, BcMF27, in pollen development. Knockdown of BcMF27 led to pollen wall collapse, 20% of which unknown material adhered to. Wall-collapsed pollen had abnormally thick intine outside of the germinal furrows. A portion of the cytoplasm was degraded in the remaining pollen with unknown material on the wall, in addition to a thick intine. Overexpression of BcMF27 resulted in 66.67% pollen wall disruption, causing an abnormally thick intine. In addition, functional interruption of BcMF27 gave rise to pollen tubes twisted in vitro. Taken together, BcMF27 contributes to the intine morphogenesis during pollen development and stabilizes pollen tube elongation. This research can promote knowledge of PMEs function and the molecular mechanism in pollen wall construction.