bluuebunny/crossref_metadata_2025 huggingface dataset:
МЕТОДИЧНИЙ ПІДХІД ДО ОЦІНЮВАННЯ ТЕНДЕРНИХ ПРОПОЗИЦІЙ
Authors: Поколенко В. О. , Любий Є. В.
Published: December 2019

Для генеральних підрядників, субпідрядних підприємств і служб замовників будівництва актуальним є створення методичного підходу до оцінювання тендерних пропозицій, аналіз різних способів і методів оцінки тендерних пропозицій, що дозволить службам замовникабільш обґрунтовано і багатостороннє оцінювати тендерні пропозиції, а підрядним підприємствам перед тим як приймати участь у тендерах здійснити аналіз власних переваг та недоліків,завчасно убезпечивши себе від багатьох помилок. Здійснено огляд передбачених законодавствомпроцедур закупівель, критерії оцінювання, етапи проведення оцінювання тендерних пропозицій.Здійснено огляд існуючих методів оцінювання тендерних пропозицій і наведено приклад використання методу для вибору тендерної пропозиції.
ІНСТРУМЕНТАРІЙ ДЕРЖАВНОГО РЕГУЛЮВАННЯ БУДІВНИЦТВОМ
Authors: Федун І. Л. , Чуприна Ю. А.
Published: December 2019

Запропоновано напрямки з удосконалення інструментарію державного регулюваннябудівництвом шляхом розробки цільових програм державноприватного партнерства. Розглянуто становлення програмноцільових методів регулювання у історичному аспекті, законодавчута нормативну бази, динаміку розвитку цього процесу. Виявлено деструктивні чинники, щостоять на заваді ефективній реалізації державного регулювання будівництва, серед яких відсутність превентивних заходів для попередження негативного розвитку, неузгодженість поставлених цілей, відсутність вибору пріоритетів, належного контролю, методик оцінки ефективності програм тощо. Виявлено, що складовими механізму державного регулювання будівництва, які потребують удосконалення, є система оцінки дії інструментів державної політики(бюджетних, податкових, тарифних, митних, нормативного регулювання) та планування капітальних і поточних витрат. Пропонується при формуванні механізмів державного регулювання будівництвом ширше застосовувати програмноцільові методи регулювання, які уданий час є стрижневим елементом державного регулювання, здійснити розробку системипріоритетів інвестування, сформувати нову систему оцінки.
ЕКОНОМІЧНІ ПІДХОДИ ДО ІНТЕЛЕКТУАЛІЗАЦІЇ БУДІВЕЛЬ
Authors: Павлій С. В.
Published: December 2019

Узагальнено економічні підходи до інтелектуалізації будівель і споруд. Проаналізовано особливості і перспективи впровадження цих систем у вітчизняному та зарубіжному проектуванні житлового середовища, виявлено градацію будівель за вартістю інтелектуалізації1м2 будівлі в дол. США в залежності від категорій житла та економічна ефективність інтелектуальних будинків
More power to physiotherapy
Authors: Andrew Hague
Published: December 2019

For a hundred years, medicine has been based on biochemistry. That has now reached its limits. Drugs, all drugs, have side effects. Healing problems that these drugs cannot cure is now possible with biophysics using pressure and electricity without poisons or opening the body. The results are safe and spectacular.

This article examines the benefits of biophysics for physiotherapists who are now able to achieve more by using better tools.
Prostate cancer cured in a week by machine without side effects
Authors: Andrew Hague
Published: December 2019

We had two patients with prostate cancer at the Vitamed Clinic in Aleksandrów ?ódzki.

First patient Mr S, age 65, had a problem with urinary incontinence in the night and also problem with urination, he felt burning. This patient didn't take chemo and radiation. We started with the first treatment on 24th of June 2019 on Monday. The second treatment was on Wednesday on 26th of June. He declared that he felt the difference. He said that he didn't feel burning when urinating. Third treatment was on Friday 28th of June. Patient said that his night urinary incontinence stopped. He felt good. After third treatment after two weeks patient decided to do blood test and ultrasonography. Blood tests confirmed that he is cured and on ultrasonography he observed that the tumour is getting smaller. At the end of August, the patient repeated tests, blood and ultrasonography. The tests said clearly that he is cured, and ultrasonography confirmed that the tumour is much smaller.
The concepts and features of the models of venture investment of energy-oriented startups
Authors: Pankiv Oleh
Published: December 2019

The theoretical and methodological principles of promising managerial decisions concerning the efficiency of attracting financial resources, as well as creation of fundamentally new sources of funding for the development of energy-oriented start-ups are considered. The role and place of the sectors of innovative energy saving and alternative sources of power supply in a complex system of energy independence of the country are determined. The way and the main directions of research and development of the ways to solve the aforementioned problem are outlined. As part of the search for optimization solutions, it is suggested to use the principles of the existing statistical and mathematical apparatus, marketing achievements and achievements in network development that take place in gaming business. An analogue comparison of the principal models was carried out, during which the existing types of energy-oriented start-ups were determined and presented. A separate direction in the economic search is proposed, and its profile characteristics are outlined. The type of model is typical for Ukrainian conditions. The author proposed a method of comparing strategies for attracting financial resources into a gaming business in the core of the research. To solve the investigated problem, it is proposed to apply the property of the law of the emergence. The analysis is based on a concrete example of the functioning of the tender procedure, namely the organization of public procurement. The purpose of the article is to consider and analyze the author's proposal to focus on such an important phenomenon as the constant creation of the difference between the expected price and the final contractual price. The model of the solution is based on the systematic combination of this phenomenon and the administrative stimulation of implementation of exclusively energy-innovation projects. The combination of these two points is the basis of an optimization policy for the potential formation and maintenance of a state program to search and stimulate the sources of funding for power plants.
The features of transnational corporations’ advertisement in social networks
Authors: Mushka Daniella , Erfan Yeva
Published: December 2019

This scientific article considers all aspects, modern importance and growing role of the social media marketing and advertisement in the general spectrum of marketing activity for developed and developing brands. Investigational actuality and basic directions of application of all spectrum of instruments of social networks for the sake of advancement of product and the processes of forming perception of trade mark and forming the image of brand are analyzed by the authors of the article. The given scientific article highlights the most popular trends and patterns of goods and trademarks’ promotion in the world in the context of updating the concept of advertising on social networks. The bigger and more engaged your target audience is on social media networks (Instagram, Facebook, Twitter, YouTube etc), the easier it will be for you to achieve every other marketing or business goal. The importance of social media marketing’s assistance in attracting new potential clients and customers to the company is also considered in the given article. Besides that, the authors of the article list and analyse wide spectrum of basic trends considering promotion and advertising in 2019 among the well-known brands. In addition to this all, the list of the most successful publicity advertisement campaigns of this year and brands which were promoted with their assistance are listed and analysed. In the context of the study, it shows up that advertising campaigns play a significant role not only in reaching sales but also in generating overall customer loyalty to the brand. This makes it possible to argue that the most reputable brands should have an important social goal that will be positively accepted by society and target audience in addition to the high quality and usability of the products or services. Social networking is the easiest way to see the social response to your promotion and lead to an instant purchase. Therefore, relying on the experience of the already well-known multinational and transnational corporations, social media marketing should take a significant share of the overall promotion of the company. The connection between the brand and potential customer should be built on the emotions that accompany consumers when viewing ads and using products. This scientific article eventually declares conclusions and prognoses in relation to subsequent development of these instruments and platforms for advancement and branding of small and large enterprises in future. It states that emotional connection between person and brand is much more effective for the company than an expensive ad.
Estimation of economic specialization of Ukrainian regions in the context of global trends
Authors: Ishchuk Svitlana , Sozanskyy Lyubomyr
Published: December 2019

The scale and deep heterogeneity of the national economy of Ukraine in the regional context make the relevance of scientific research in this thematic area. The purpose of the article is to determine the economic specialization of the regions of Ukraine by key economic activities contributing to the formation of gross value added, as well as outlining the potential risks to the national economy, taking into account the situation on world commodity markets. The results of the research showed that one of the consequences of the unstable dynamics of industrial production in Ukraine under the influence of geopolitical and macroeconomic factors is the reduction of industrial specialization of the economy of a number of Ukrainian regions. Thus, in 2017 the manufacturing was the leading economic activity (with the highest share in the gross value added created) in 11 regions, compared to 15 in 2012. So Poltava, Donetsk, Dnipropetrovsk and Zaporizhzhya regions are considered to be “highly industrial”. At the same time, the agrarian specialization of the economy of Ukraine and its regions deepened – in 2017 agriculture became the leading type of economic activity in 11 regions (compared to 7 in 2012). The most “agrarian” in Ukraine (with a share of agriculture in gross value added over 30%) in 2017 became the Kherson, Kirovohrad and Khmelnytsky regions. Increasing the level of “agrarianization” of the national economy in the context of volatility of agricultural commodity prices on the world markets poses significant risks for the socio-economic development of Ukraine and its regions. These risks are exacerbated by the high amplitude of fluctuations in the volume and structure of domestic agricultural products and the low degree of processing of raw materials. To improve the structure of domestic commodity exports (in the direction of increasing its share of products with a higher degree of processing) and to deepen its diversification, a number of measures should be carried out aimed at stimulating export activity of enterprises (industrial and agro-industrial), carrying out technical and technological re-equipment of industrial and export production bases, creation of new high-tech industries on the basis of the implementation of powerful innovation and investment projects.
Tendencies of grain production and processing in the regions of Ukraine
Authors: Lyakhovska Olena
Published: December 2019

The volumes and changes in grain production in the regions of Ukraine are analyzed. The grain production volumes are revealed to have increased by 11.11% in 2013-2018. Poltava, Vinnytsia and Chernihiv regions were the leaders among the regions, where they produced about 24.5% of the total grain in Ukraine. The paper determines that high levels of grain production have led to an oversaturation of the domestic market and increased exports of this product. At the same time, the volumes and growth rates of wheat or wheat-rye flour, which is the basis of deep processing, decreased. The production of this grain processing product is concentrated in Vinnytsia, Kharkiv, Kyiv, Dnipropetrovsk and Khmelnytsky regions. In total, more than 50% of flour from the total production in Ukraine were produced in these regions in 2018. According to trends in grain production and its processing, regions of Ukraine are grouped into: regions with high levels of grain production and processing (Vinnytsia, Kharkiv, Kyiv, Dnipropetrovsk and Khmelnytsky); regions with high levels of grain production and low volumes of its processing (Poltava, Chernihiv, Cherkasy, Sumy, Odesa, Kirovohrad oblasts); regions with a tendency to increase the volumes of grain processing (Zhytomyr, Lviv and Volyn oblasts); regions that increase grain production, but the volume of its processing decreases (Ternopil, Kherson, Zaporizhia, Rivne and Ivano-Frankivsk and Mykolaiv); regions with a tendency to decrease the volume of grain production and processing (Donetsk, Luhansk, Zakarpattya and Chernivtsi regions. The ways of further development of these regions in terms of grain production and processing are suggested. The following measures will contribute to consolidation of positive trends in grain production: updating of technological support of grain production in order to reduce its cost and increase the opportunities for creating an ecological product that will be competitive in the world market; increase of elevator capacity, which will prevent the risk of losses due to poor storage of products.
Relationship between Canadian medical school student career interest in emergency medicine and post-graduate training disposition
Authors: Abu-Laban Riyad , Scott Ian , Gowans Margot
Published: December 2019

Background: Canada has two independent routes of emergency medicine (EM) training and certification. This unique situation may encourage medical students with EM career aspirations to apply to family medicine (FM) residencies to subsequently acquire College of Family Physicians of Canada (CFPC) training and certification in EM. We sought answers to the following: 1) Are medical students who indicate EM as their top career choice on medical school entry, and then complete a FM residency, more likely to undertake subsequent CFPC-EM training than other FM residents who did not indicate EM as their top career choice; and 2) What are the characteristics of medical students in four predefined groups, based upon their early interest in EM as a career and ultimate postgraduate training disposition.Methods: Data were accessed from a survey of medical students in 11 medical school classes from eight Canadian universities and anonymously linked to information from the Canadian Residency Matching Service between 2006 and 2009.Results: Of 1036 participants, 63 (6.1%) named EM as their top career choice on medical school entry. Of these, 10 ultimately matched to a Royal College of Physicians and Surgeons of Canada (RCPSC) EM residency program, and 24 matched to a FM residency program, nine of whom went on to do a one-year CFPC-EM residency program in contrast to 57 of the remaining 356 students matching to FM residency programs who did not indicate EM was their top career choice (37.5% vs 16.0%, p=0.007). Statistically significant attitudinal differences related to the presence or absence of EM career interest on medical school entry were found.Conclusion: Considering those who complete CFPC-EM training, a greater proportion indicate on admission to medical school that EM is their top career choice compared to those who do not. Moreover, students with an early career interest in EM are similar for several attitudinal factors independent of their ultimate postgraduate training disposition. Given the current issues and challenges facing FM and EM, these findings have implications that merit consideration by both the CFPC and the RCPSC.
Evaluating the impact of a resident research program in general surgery
Authors: Allen Laura , Vogt Kelly , Mele Tina , Ott Michael , Leslie Ken , Colquhoun Patrick
Published: December 2019

Background: Programs of resident research have been found to improve research productivity. However, evidence of the success of these programs is lacking in a Canadian context. The objective of this study was to evaluate the impact of the introduction of a formal program of resident research at a single Canadian academic centre.Methods: Resident research activities were tracked over a 10-year period (Resident Research Day (RRD) presentations, abstract presentations, published articles). Activities were divided into pre (2002-2007) and post (2007-2012) resident research program implementation time frames. Differences in research productivity were compared between time frames. Surveys of resident attitudes towards research were administered prior to the program’s implementation in 2007, and following introduction of the resident research program in 2009 and 2015.Results: Overall, research productivity (abstracts, publications, and RRD presentations) increased between pre and post resident research program time periods, with a statistically significant increase in mean number of published abstracts. Resident attitudes towards research changed somewhat over time, with fewer residents supporting mandatory research in recent years.Conclusion: Implementation of a resident program of research resulted in a significant increase in research productivity. The setting of clear, modifiable, and achievable goals, as well as providing tools for research success, have contributed to the success of this program.
Something’s missing from my education: Using a cross sectional survey to examine the needs and interest of Canadian medical students relating to their roles as teachers and educators
Authors: Nagji Alim , Leslie Karen , Wong Eric , Myhre Doug , Young Meredith , Chan Ming-Ka
Published: December 2019

Background: Current theory in medical education emphasizes engaging learners as educators while tailoring teaching to their learning needs. However, little is known about learners’ perceptions of their proposed roles as teachers and educators.Methods: Canadian medical students were invited to complete an English language online questionnaire structured to include: teaching experience, participation and/or awareness of teacher development at their school and awareness and/or interest in further training in medical education. The survey was developed by the Canadian Association for Medical Education (CAME) Membership Subcommittee, and distributed via the Canadian Federation of Medical Students (CFMS) email list and the CAME twitter account in March 2014.Results: Of the 169 undergraduate medical student respondents, 36% (n=61) reported a lack of prior teaching experience and 45% (n=73) were unsure if their school provided teaching instruction. Overall, 91% (n=150) indicated that they planned to incorporate teaching or medical education into their future careers.Conclusion: While the majority of medical student respondents are expecting or planning to teach, most report not having access to adequate training through medical school. Further effort is necessary to support medical students as teachers to prepare them for increased teaching responsibilities as residents and to expose them to potential careers in medical education.
Training the trainers: a survey of simulation fellowship graduates
Authors: Hughes Patrick , Brito Jose Cepeda , Ahmed Rami
Published: December 2019

Background: Coupled with the expansion of simulation has been the development and growth of medical simulation fellowships. These non-accredited fellowships do not have a standardized curriculum and there are currently no studies investigating the simulation fellowship experience. The purpose of this study was to explore the simulation fellowship experience of graduates throughout North America and how it prepared them for their post-fellowship career.Methods: A web-based survey was developed by Emergency Medicine attending physicians both of whom completed one-year fellowships in medical simulation. Prior to distribution, the survey was reviewed and tested by three simulation fellowship graduates and a PhD researcher. Feedback was integrated into the survey prior to distribution. The survey consisted of a maximum of 29 multiple choice questions including two step-logic questions and two open response questions. The survey was distributed to simulation fellowship directors in multiple disciplines and the directors were asked to forward the survey to graduates. Additionally, the Society for Academic Emergency Medicine Simulation Academy list-serve was utilized for distribution of the survey.Results: The survey had 35 responses. The majority of respondents completed fellowship within the last two years (66%, 23/35). Fellowship graduates strongly agreed or agreed that their fellowship adequately prepared them for their post-fellowship simulation career (88%). Graduates report that research design/reporting (53%) and administration (18%) were areas of their fellowship curriculum that needed the most improvement.Conclusion: The majority of simulation fellowship graduates agreed that their fellowship experience adequately prepared them for their post-fellowship simulation career. Graduates also felt that training in research and administration are areas that could be improved.
Perceptions, practice, and “ownership:” experiences in continuity of the patient-doctor relationship in a family medicine residency
Authors: Lee Ann , Kennett Sandra , Khera Sheny , Ross Shelley
Published: December 2019

Background: The objective of this mixed-methods study was to determine interpersonal continuity (the ongoing therapeutic relationship between patient and health care provider) experiences of family medicine residents and preceptors, and explore their perceptions of interpersonal continuity.Methods: Quantitative data on resident and preceptor encounters were extracted from the electronic medical record (EMR). Opportunities for developing interpersonal continuity were determined using the Usual Provider Continuity (UPC) Index. A qualitative descriptive research method was used for the qualitative portion. Semi-structured interviews were conducted and constant comparative analysis was used to determine emerging themes.Results: Residents were found to have low UPC rates; preceptor rates were higher. Qualitative findings showed variable experiences with interpersonal continuity not apparent from UPC rates. Both preceptors and residents expressed perception of “ownership” of patients as a significant barrier to interpersonal continuity. Conclusion: This study suggests that a perceived lack of individual “ownership” of a patient panel was a significant barrier to developing interpersonal continuity. This might conflict with current changes towards team-based health care delivery. Understanding perceptions and changing them through a multi-faceted approach including resident teaching and faculty development might help improve interpersonal continuity which are core to both family medicine curricula and current models of health care delivery.
Factors Related to the Success of Endovascular Therapy with Plain Old Balloon Angioplasty of Central Vein Stenosis in Haemodialysis Patients
Authors: Muradi Akhmadu , Firdhianto Donie , Kekalih Aria
Published: December 2019

Introduction: Central venous stenosis (CVS) or occlusion is a severe complication in hemodialysis patients, which significantly decreases the patency of all vascular dialysis access components, including arteries and branches, AV anastomosis, peripheral veins, and central veins. The main etiology of CVS is mostly secondary to the placement of temporary or permanent dialysis catheters in the subclavian vein, internal jugular vein, and femoral vein. Standard endovascular therapy for central venous stenosis is conventional balloon angioplasty.

Method: This is a retrospective study using medical records from June 2013 to August 2018. Patients who underwent plain old balloon angioplasty (POBA) procedures in the CVS condition due to the installation of hemodialysis catheter access were included in this study. The analysis was performed to assess the characteristics and data distribution of each variable.

Results: Significant factors related to the success of endovascular procedure in patients with central venous stenosis with POBA were the onset of clinical symptoms (<3 months; p <0.001), duration of catheter placement (<2.5 months; p <0.001), history of previous catheter placement (no more than once, p <0.001), initial stenosis (<80; p <0.001), and diameter of POBA (≥ 10 mm; p <0.001).

Conclusion: Some factors influenced the success of the POBA procedure for overcoming CVS. The need to understanding the use of hemodialysis catheter access according to the guideline is important.

Keywords: central venous stenosis, endovascular therapy, plain old balloon angioplasty
The Relationship Between Renal Artery Stenosis and Degree of Angio Score on the Lower Extremity Peripheral Arterial Disease in Cipto Mangunkusumo Hospital
Authors: Utama Alexander Jayadi , Kam Hippocrates , Kekalih Aria
Published: December 2019

Introduction: The most common cause of the peripheral arterial disease (PAD) is atherosclerosis. PAD is associated with other atherosclerotic diseases such as renal artery stenosis (RAS). Life expectancy decreases in patients with RAS, especially those whose stenosis is above 60% but has not reached the stage of chronic kidney failure. This study aims to determine the prevalence of RAS in PAD patients, the relationship between angiographic scoring system (ANGIO Score), history of hypertension, and diabetes mellitus with the degree of RAS.

Method: This research was a cross-sectional study conducted at Cipto Mangunkusumo Hospital from February to May 2019. Patients with a diagnosis of lower extremity PAD and had been assessed with CT angiography examination, were included in this study. The degree of RAS and ANGIO Score were calculated. Sampling was done by the total sampling method.

Results Most patients were women 33 (50.8%), while men were 32 (49.2%). 90.8% of the patients had diabetes, while 61.5% of the sample had hypertension. Grade 1 RAS was the most found. There was no correlation between ANGIO Score on age, sex, and diabetes mellitus, but there was a significant relationship with hypertension. There was a relationship between RAS with age and hypertension, but there was no relationship with diabetes mellitus and gender. ANGIO Score and RAS had a significant relationship (p <0.001).

Conclusion: There was a relationship between the ANGIO Score and the severity of RAS. The cut-off score of 9 for the ANGIO Score had a sensitivity of 85.7% and a specificity of 61.4% for predicting RAS.

Keywords: peripheral arterial disease, angiographic scoring system, renal artery stenosis, CT angiography
Correlation between Serum Level of Vitamin D and Severity Degree of Diabetic Foot Ulcer in Patients with Normal Ankle Brachial Index
Authors: Harris Saleh , Suhartono Raden , Kekalih Aria
Published: December 2019

Introduction: Diabetes mellitus can cause various complications, including diabetic foot ulcers (DFU). Vitamin D levels are known to be correlated with wound healing and insulin resistance.

Method: This cross-sectional study aimed to determine the correlation between the serum level of vitamin D and the severity degree of DFU. Thirty DFU patients with normal ankle- brachial index, grouped into degrees according to the Wagner classification, were included in this study. Their serum level of vitamin D was examined using the chemiluminescent immunoassay method. The correlation between these two variables was analyzed.

Results: Patients were 18 males (60%) and 12 females (40%) with an average age of 57 years. The average serum level of vitamin D was 10.58 ng/mL. A significant correlation was found between the serum level of vitamin D and the severity of DFU (r= -0.901, p <0.001).

Conclusion: The serum level of vitamin D screening in DFU patients was strongly correlated with the degree of DFU.

Keywords: diabetes mellitus, diabetic foot ulcer, vitamin D, Wagner classification
Biodiversitas dan Identifikasi Jamur Basidiomycetes di Taman Nasional Sebangau, Kabupaten Katingan Kalimantan Tengah
Authors: Putir Patricia E , Tanduh Yusintha , Firdara Eritha K
Published: December 2019

Masyarakat yang tinggal di sekitar hutan, pada umumnya sangat bergantung pada hasil hutan, baik itu hasil hutan berupa kayu maupun hasil hutan yang bukan berupa kayu. Kebutuhan masyarakat akan hasil hutan khususnya hasil hutan non kayu seperti damar, kemenyan, jamur, madu hutan serta produk lainnya akan semakin berkurang dengan beralihnya fungsi lahan hutan. Jamur merupakan salah satu produk hasil hutan non kayu yang paling disukai karena dapat dicari dengan mudah. Tujuan penelitian ini adalah untuk mengetahui jenis-jenis jamur Basidiomycetes serta untuk mengetahui jenis jamur pangan dan jamur obat yang ada di kawasan penelitian Punggualas Taman Nasional Sebangau. Metode penelitian yang digunakan adalah dengan metode eksplorasi dan identifikasi dengan membuat plot  ukuran 150 m x 100 m dengan jalur pengamatan jamur sebanyak 5 jalur, jarak antar jalur adalah 5 m dan lebar jalur 20 m. Hasil penelitian ditemukan 15 famili jamur Basidiomycetes,  49 jenis jamur dan jumlah individu jamur sebanyak 789 buah. Berdasarkan jumlah individu maka jamur Aucularia auricula merupakan jamur yang dominan tumbuh di Taman Nasional Sebangau. Indeks keanekaragaman (H´)=2,6260 tergolong sedang. Indeks kekayaan R=7,1956 tergolong tinggi dan indeks kemerataan E1=0,6747 tergolong sedang. Jamur Auricularia auricula (jamur kuping/kulat bitak) dan Pleurotus sp. (jamur tiram/kulat puti) termasuk jamur yang dapat dikonsumsi dan jamur Ganoderma applanatum termasuk jamur yang dapat digunakan sebagai bahan obat. Substrat jamur.
Effects of Different Doses of Curcumin on Apoptosis, Mitochondrial Oxidative Stress and Calcium Ion Influx in DBRG Glioblastoma Cells
Authors: ÖZ Ahmi , ÇELİK Ömer , ÖVEY İshak Suat
Published: December 2019

Transient Receptor
Potential (TRP) channels superfamily has mostly calcium ion (Ca2+)
permeable non-selective cation channels. Transient receptor potential
melastatin subfamily 2 (TRPM2) is widely expressed in central nervous system. Intracellular
Ca2+ concentration ([Ca2+]i) may change depend
on TRPM2 and TRPM8 activations from extracellular liquid to cytosol. Curcumin
as natural antioxidant shows phenolic structure, synthesized by Curcuma longa L. (Indian saffron, turmeric),
has powerful non-enzymatically antioxidant effects. Low dose curcumin treatment
can decrease calcium signaling via
TRPM2 channel inhibition and prevent elevation of [Ca2+]i levels.
Hence, we investigated effects of four different concentrations (5, 10, 25
and 50 µM) of curcumin on apoptosis and cell viability (MTT), reactive oxygen
species (ROS) production, mitochondrial membrane potential levels, caspase 3
and caspase 9 values in DBRG glioblastoma cells.             We
found that curcumin reduces cell viability by concentration dependent manner.
It was also observed that curcumin induces apoptosis via caspase 3 and 9
related pathways. However, it was not found any direct relationship between the
effect of increased concentrations of curcumin and inhibition or activation of TRPM2
mediated Ca2+ signaling in the DBTRG cells. The [Ca2+]i
concentration was lower in 5 µM group as compare to control group. Curcumin acted
important role on decrease of mitochondrial membrane potential and
intracellular ROS production in the cells. Moreover, curcumin treatment
markedly supported GSH concentration levels in the cells. 

In conclusion, it was firstly assessed the effects of different
doses of curcumin on TRPM2 mediated calcium signaling and interaction with
various apoptosis parameters in DBTRG glioblastoma cells.
L’interdisciplinarité en santé dans le champ de la petite enfance : un point de vue anthropologique
Authors: Teixeira Maria
Published: December 2019

L’interdisciplinarité tant recherchée est parfois difficile à mettre en place. Il existe de nombreuses difficultés d’ordre épistémologiques et méthodologiques, des problèmes de poids différent des disciplines, de reconnaissance réciproque. Par ailleurs la césure entre recherche fondamentale et recherche appliquées ne se dépasse pas si facilement. Certains anthropologues répugnent à s’investir dans une recherche appliquée. Les bébés sont une extraordinaire porte d’entrée pour appréhender les différentes sphères matérielles, spirituelles et idéelles d’une société. Comprendre les représentations collectives de la conception et du modelage des bébés en vue de construire leur humanité et leur insertion dans un système de parenté et d’attitudes précis permet d’identifier, lorsqu’il y a dysfonctionnement de l’adaptation, des pistes pour aider les familles en souffrance. Ainsi, ethnopsychiatres et anthropologues peuvent collaborer afin d’aider ces petits en souffrance.
From Juanita Dark to Dolores: the palimpsestic presence of Joan of Arc in Nabokov’s Lolita
Authors: Bouchet Marie
Published: December 2019

Nabokov avait initialement nommé sa célèbre héroïne « Juanita Dark », et pourtant la présence de Jeanne d’Arc dans Lolita semble s’être effacée au fil de l’écriture du roman. Cet article défend toutefois l’importance du motif de Jeanne d’Arc, car il s’inscrit dans un motif multiculturel central de l’œuvre de Nabokov, celui de la jeune martyre, qui parcourt l’œuvre de l’écrivain, de ses poèmes russes à ses romans américains ultérieurs, et s’inscrit dans la lignée de plusieurs figures intertextuelles et culturelles : la roussalka russe, l’Inconnue de la Seine, Ophélie, les esclaves de harem, et Jeanne d’Arc. Après avoir présenté les références à cette dernière dans les œuvres précédant Lolita , cet article montre que le palimpseste de références intertextuelles, filmiques et culturelles à Jeanne d’Arc qui est subtilement entrelacé dans le texte contribue à enrichir le réseau de motifs et d’énigmes littéraires qui mine le récit de Humbert et révèle le martyre de Lolita.
Private Eyes: Detecting Gabriel Levin’s Poetry
Authors: Vernon Peter
Published: December 2019

Cet article analyse le dernier recueil de Levin, Errant , dans le contexte de son œuvre. Il s’agit de présenter et d’étudier un poète d’un talent exceptionnel mais injustement méconnu. Après une brève introduction biographique, cet article considère les thèmes et les techniques poétiques principaux des cinq recueils précédents, avant d’examiner le dernier plus précisément. Levin est un poète d’expression complexe, notamment parce que les centres d’intérêt évoqués dans sa poésie s’étendent du Moyen-Orient à l’Occident, mais aussi parce qu’il s’écarte constamment des normes des formes poétiques établies, ce qui a pour effet de déstabiliser le lecteur. Néanmoins, son humour et sa modestie lui permettent d’éviter tout effet de pompe, et sa poésie récompense le lecteur assidu d’un message profondément humaniste et du plaisir de partir à la découverte, à travers la beauté de ses vers.
Vers un individualisme substantiel : images de l’enfant et sagesse de l’individualisation. Une lecture de Marcel Gauchet
Authors: Roelens Camille
Published: December 2019

Cet article explore le corpus de textes consacrés par Marcel Gauchet à l’éducation et à l’enfance, à l’aune de son œuvre globale. Une première partie présente chronologiquement des textes permettant de percevoir son élaboration progressive d’une image de l’enfant dans la modernité démocratique. Une seconde partie montre que c’est par le prisme des vulnérabilités de l’autonomie, qui précipitent dans le rapport à l’enfant, qu’une sagesse renouvelée de l’enfance peut s’esquisser. L’apport d’une telle démarche à une sagesse de l’individualisme et à un humanisme renouvelé est synthétisé pour conclure.
Des dérives d’un usage métaphorique de l’enfance
Authors: Piterbraut-Merx Tal
Published: December 2019

Il n’existe pas, à proprement parler, de philosophie de l’enfance, et pourtant l’enfance en philosophie se retrouve abondamment sous les plumes des philosophes, en particulier sous un usage métaphorique. Il s’agira dans cet article d’interroger les présupposés qui structurent ces métaphores pour mieux saisir la conception de l’enfance empirique développée en creux, mais aussi la charge politique qui les sous-tend. Nous pourrons à partir de là formuler quelques propositions pour un bon usage de la métaphore en philosophie politique.
Du modèle à l’exemple : littérature et éducation morale
Authors: Finet Béatrice
Published: December 2019

Les dernières instructions officielles pour l’école élémentaire préconisent que la question de la morale soit abordée dans le cadre du cours de français en cycle 3. L’analyse d’un manuel, qui met en œuvre les propositions de ces dernières instructions officielles, montre que le thème « la morale en question » imposé aux enseignants se réduit à une moralisation des élèves et ne permet pas une réelle éducation morale. En m’appuyant sur la pensée de Martha Nussbaum, je montre les enjeux d’une véritable éducation morale, celle de l’émancipation du sujet réflexif, à partir de la littérature, dès le plus jeune âge. Pour ce faire, on distinguera modèle et exemple, éducation à la morale et éducation morale.
L’école primaire et le récit colonial sur la nature (1870-1914)
Authors: Dasi Pierre
Published: December 2019

Il s’agit, dans cet article, de montrer comment la représentation de la nature à l’école primaire entre 1870 et 1914 a été mise au service du projet colonial de la Troisième République. En effet, se déplie dans la littérature scolaire un discours construit autour de la dialectique de la terre bénie d’un côté tandis que de l’autre est martelée l’idée que les territoires à conquérir sont abandonnés à la sauvagerie par des indigènes ignorant tout de la gestion de la nature. Fort de ce discrédit des autochtones, l’école républicaine s’est efforcée de susciter chez les petits Français des vocations, afin de faire de cette nature indomptée une nouvelle terre promise. Au corbillon de la mission civilisatrice de l’homme blanc, les autorités scolaires ont ainsi ajouté le fardeau écologique, autre moyen de disqualifier l’histoire des sociétés précoloniales.
Montaigne, passeur-inventeur du Plutarque-éducateur
Authors: Machado Eduardo
Published: December 2019

Nous défendons ici l’idée que l’usage éducatif que Montaigne fait de la pensée de Plutarque ne se restreint pas, comme on l’a souvent cru, à un simple pastiche ou à de nombreux emprunts. Il ne s’agit pas non plus uniquement d’une simple réminiscence, mais bel et bien d’une appropriation particulière et essentielle d’un héritage éducatif, dont Plutarque est tout à la fois le porteur et le diffuseur. Aussi nous étudierons la réception montanienne de la figure du Plutarque éducateur dans ses différentes dimensions.
Methicillin-Resistant Staphylococcal Infections: An Important Consideration for Orthopedic Surgeons
Authors: Shams Wael E , Rapp Robert P
Published: December 2019

Current US guidelines recommend screening for methicillin resistant Staphylococcus aureus and methicillin resistant coagulase-negative staphylococci prior to orthopedic surgery.
Functional Assessment Using the Step-Up-and-Over Test and Forward Lunge Following ACL Reconstruction
Authors: Mattacola Carl G , Jacobs Carl A , Rund Mark A , Johnson Darren L
Published: December 2019

abstract

This investigation compared lower extremity function of a control group and a group of patients who underwent anterior cruciate ligament (ACL) reconstruction using a repeated measures post-test only control group design. The ACL reconstruction group consisted of 18 patients at least 6 months postoperative (mean 58±19 weeks) and the control group consisted of 18 healthy, recreationally active individuals. Both groups performed a step-up-and-over test and a forward lunge on a long force plate. During the step-up-and-over test, the control group produced significantly more force during the initial step than the ACL reconstruction group. Also, when the ACL reconstruction patients led with the involved extremity, they were significantly slower. During the forward lunge test, the impact index and force impulse measurements were significantly greater for the uninvolved leg than the involved leg in the ACL reconstruction group. The implications are that force generation during functional tests may remain compromised for >1 year following reconstruction. The aforementioned tests are promising for evaluation of function following ACL reconstruction.
Blood Management in Patients with Deep Prosthetic Hip and Knee Infections
Authors: Lee Gwo-Chin , Cushner Fred D
Published: December 2019

abstract

Patients undergoing treatment for infected hip and knee replacements often have significant blood loss and require allogeneic blood transfusions. In the setting of sepsis, traditional methods of blood management such as preoperative blood donations, cell savers, and reinfusion drains are contraindicated. Pharmacologic agents can minimize transfusion requirements by increasing erythropoiesis, or minimize perioperative blood loss. This article reviews the use of these agents in the management of patients with deep prosthetic hip and knee infections.
The Antibiotic Cement Nail for Infection After Tibial Nailing
Authors: Madanagopal Sudhakar G , Seligson David , Roberts Craig S
Published: December 2019

This article introduces the antibiotic-impregnated cement nail for the treatment of tibial shaft fracture infection anda outlines the technique regarding its placement.
Is This Patient Penicillin-Allergic?
Authors: Sheth Anjly , Smith Kelly M
Published: December 2019

Increased claims of hypersensitivity reactions are being reported due to the inability to differentiate between the terms "allergic reaction" and "adverse effect."
The Effectiveness of rhBMP-2 in Replacing Autograft: An Integrated Analysis of Three Human Spine Studies
Authors: Burkus J Kenneth , Hei Stephen E , Gornet Matthew F , Zdeblick Thomas A
Published: December 2019

In anterior lumbar spinal fusion, patients treated with rhBMP-2 on a collagen sponge carrier had statistically superior outcomes compared to patients treated with autogenous bone graft. A collagen sponge carrier should replace autogenous bone graft for this patient population.
On Microclimatic Islands. The Garden as a Place of Intensified Thermal Experience
Authors: Roesler Sascha
Published: December 2019

Gardens have always been appreciated as places of particular microclimatic qualities. Seen within the broader context of Enlightenment, gardens can be conceived as places of intensified thermal experience and as man-made concentrations of climate. In the first part, remarks on the aesthetics of microclimates, based on the perception of gardens, will be presented. In times when microclimates were not yet measured by scientific means, the thermal differences found in gardens have already been described as part of poetry and painting or in the treatises of gardeners and botanists. In the second part, the scientification of microclimates and its entanglement with concepts of urban green spaces shall be discussed. Over the course of the 20th century, gardens and green spaces became mitigating measures, fighting severe microclimatic conditions of cities, in particular the so-called urban heat islands. In the third part, the central role of movement in recognizing thermal differences in cities will be highlighted. Two pioneering projects, aiming at exploring the environmental “archipelagos” of cities, will be highlighted. The (garden) cities of Bath (UK) and San Francisco (USA) have been the urban territories for multi-sensorial walks of architect Peter Smithson and landscape architect Lawrence Halprin, both of which took place in 1966. The movement-oriented and body-centred approaches of Smithson and Halprin are historical forerunners of today’s interest in the exploration and cultivation of the microclimatic dynamics of cities and their social and cultural values. Even more than being geometric and spatial entities, microclimates relate directly to the body with its thermal sensations.
Habiter sur serre à Eden Square. Un espace collectif tempéré à l’épreuve de ses habitants
Authors: Foucher-Dufoix Valérie , Overney Laetitia
Published: December 2019

Cet article porte sur l'étude d'un immeuble bioclimatique de 87 logements organisés autour d’une serre végétalisée, Eden Square, livré en 2012 dans l’agglomération de Rennes, en France, par les architectes Christian Hauvette et Pierre Champenois, qui le décrivent comme « une utopie sociale et écologique ». Habiter sur serre constituerait a priori une expérience peu commune. Mais dans les faits, comment les habitants vivent et perçoivent-ils réellement Eden Square ? Qu’en est-il du plaisir d’habiter sur serre ? A-t-on affaire à un Eden et un espace hyper-conditionné ? L’article s’appuie sur une enquête sociologique réalisée entre 2017 et 2019 auprès des habitants de l’immeuble. Il montre comment le plaisir d’habiter ces espaces tient avant tout à l’expérience sensorielle, à l’agrément du parcours, au confort des logements, aux performances thermiques, sans pour autant générer de vie collective particulière. Eden Square n’est pas vécu par ses habitants comme un immeuble-monde, autocentré sur la serre comme une entité sociale autonome sans qu’ils n’aient de lien avec l’extérieur. Pour autant, la serre reste un espace à contempler sans véritable possibilité d’appropriation.
Keeping Warm in Subtropical Winter. When Everyday Life Disrupts the Concept of Hyper-Conditioned Environments in Chongqing (Southwest China)
Authors: Kobi Madlen
Published: December 2019

The practice of regulation of indoor climates has spread globally with the rise of modern architecture and has cemented the idea of an air-conditioned indoors as opposed to a non-controllable outdoors. The ethnographic data discussed here from the metropolis of Chongqing (southwest China) presents a more nuanced picture and encourages scrutiny of the notion of “hyper-conditioned environments”. Local thermal practices are not clear-cut along the lines of indoors and outdoors; rather, everyday life takes place in a range of adjoined microclimates. Building upon the centrality of the body for perceiving thermal differences, this paper analyses the interaction of climate, landscape and architecture in an era where hyper-conditioned environments are taken for granted. The paper develops an argument for more place-based studies on how conditioning is conceived in specific contexts. In a highly urbanized setting such as Chongqing, it is not only local climatic characteristics (e.g. little wind or high humidity) that affect architecture. Further, the national political economy that promulgates poorly insulated houses or residential customs such as ventilation interfere in the warming or cooling of bodies. This paper aims to sensitize architects to conceptualizing buildings not as detached and controllable entities, but as part of urban climatic landscapes.
Three different diagnoses of similar presentations with fever, confusion and rigidity
Authors: Bandara R. P. , Ellepola A.
Published: December 2019

Patients presenting with acute muscular rigidity, fever and confusion is a management challenge in medical practice. It could be a potentially lethal case with poor prognosis. The authors of this article highlight the importance of appropriate assessment of patients to arrive at a correct diagnosis. Clinicians need to be mindful of subtle differences between differential diagnoses. Diagnostic guidelines and criteria assist in differentiating conditions. Management and outcome depends largely on the aetiology of the manifestations. The three cases reported in this paper presented with the symptom triad of muscular rigidity, fever and confusion. However, the causative conditions were different from one case to the other. Heat stroke, serotonin syndrome and neuroleptic malignant syndrome (NMS) were the diagnoses arrived at. Two patients recovered completely, while the other patient succumbed.