bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penerimaan Pajak dan Inflasi Terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Zahara Indah , Amri Khairul
Published: January 2025

The aim of this research is to analyze the relationship between tax revenues and inflation on economic growth. Using annual time series data from the 2000-2019 period. The research method used is multiple linear regression and autoregressive distribution lag (ARDL). The research results show that there is a cointegration relationship between economic growth and tax revenues and inflation. Using a multiple linear regression analysis model states that tax revenues and inflation have a positive and insignificant effect on economic growth. Furthermore, using autoregressive distribution lag (ARDL) analysis states that tax revenues have an insignificant negative effect in the long term, while in the short term tax revenues have a positive and significant effect on economic growth. Inflation has an insignificant negative effect on economic growth in the long term, but in the short term inflation has a significant negative effect on economic growth. This finding has the implication that efforts to increase economic growth can be made by keeping taxes and inflation levels at a stable level.
Pengaruh Label Halal dan Religiusitas terhadap Keputusan Pembelian Produk Kosmetik di Kota Banda Aceh
Authors: Lubis Indina Tazkiya , Yasir Muhammad , Hasnita Nevi
Published: January 2025

This study aims to analyze the influence of halal labeling and religiosity on purchasing decisions for beauty products, as well as to examine the moderating role of gender in the functional relationship between these two variables. The research sample consists of 100 cosmetic product users in Banda Aceh, selected through purposive sampling. Data collection was carried out using an online questionnaire, and the data were subsequently analyzed using multiple linear regression and moderated regression analysis. The study found that both halal labeling and religiosity have a positive and significant effect on purchasing decisions for cosmetic products. The greater the importance consumers place on halal labeling and the higher their level of religiosity, the more likely they are to purchase cosmetic products
Implementasi PSAK No. 109 Pada Organisasi Pengelolaan Zakat dan Perannya dalam Meningkatkan Akuntanbilitas dan Transparansi Pada Baitul Mal Provinsi Aceh
Authors: Safrirullah  , Furqani Hafas , Sari Nilam
Published: January 2025

This research aims to find out and analyze the implementation of PSAK No. 109 Concerning Zakat, Infaq and Sadaqah on Zakat Management Organizations (OPZ) in Increasing Accountability and Transparency in Baitul Mal Aceh Province. In this research, the methodology used is: descriptive research with a qualitative approach. The results of this research show that: (1) Baitul Mal Aceh (BMA) Aceh Province has implemented PSAK No. 109 in terms of Financial Reporting including the Aspects of Recognition, Measurement, Presentation and Disclosure of Zakat funds, Infaq/Alms and other Religious Assets (HKL) which is in accordance with the Standardization and provisions in the Statement of Financial Accounting Standards No. 109 concerning Zakat, Infaq and Alms. In terms of accountability, Baitul Mal Aceh has fulfilled the aspects of accountability and transparency as a public service in carrying out the process of auditing its financial reports every period and conveying information openly through information media (print, digital and website) regarding financial reports as a form of responsibility/accountability and transparency to the Community (Mustahik and Muzakki) and obtaining the WTP (Fair Without Exception) Predicate from the Aceh Government. (2) In the process of implementing Statement of Financial Accounting Standards No. 109 concerning Zakat, Infaq and Alms Accounting, Baitul Mal Aceh (BMA) has several obstacles or obstacles in implementing PSAK No. 109 Standardization, in the form of a lack of competent Human Resources (HR). in the field of financial accounting and the absence of a system or application/program in preparing financial reports for Zakat, Infaq and Alms.
Akuntabilitas Perencanaan dan Tata Kelola Anggaran (Studi Kasus Pada Pembangunan Mesjid Agung Al Falah Sigli
Authors: Hanif Muhammad , Nurdin Ridwan , Syahputra Hendra
Published: January 2025

This thesis examines the accountability of budgeting and budget management in the construction of the Al-Falah Grand Mosque in Sigli. The objective of this thesis is to understand the budgeting and allocation system for the mosque's construction and to assess the committee's supervision and evaluation of the construction process. This research employs a qualitative approach with a field study methodology. The primary data sources are obtained through interviews, observations, and documentation, supplemented by secondary data to strengthen and support the primary data. The results of this study indicate that the budgeting and allocation system for the construction of the Al-Falah Mosque in Sigli is funded by the Special Autonomy Fund for Aceh, proposed by the Pidie Regency Government to the Aceh Government and the Aceh Provincial House of Representatives. The allocation of funds for the mosque's construction varies each year, with 14.21% from the Special Autonomy Fund for Aceh (DOKA) in 2015, 19.64% in 2016, and so on until 8.22% in 2022. Regarding supervision and evaluation, the Pidie Regency Government issued a Regent's Regulation to monitor and evaluate all forms of processes and stages of the mosque's construction.
Tinjauan Literatur: Analisis Harga Pokok Produksi pada Penetapan Harga Jual Produk
Authors: Simamora Grace Stela Zane , Hutabalian Johs Charlos , Hutagalung Mawar Indah Juita , Matondang Khairani Alawiyah
Published: January 2025

This study examines the significance of analyzing the Cost of Goods Sold (COGS) in determining product selling prices, particularly for Micro, Small, and Medium Enterprises (MSMEs). It evaluates the differences among full costing, variable costing, and traditional calculation methods in determining COGS and their respective impacts on selling prices. The objective is to offer recommendations to MSMEs for enhancing the accuracy of COGS calculations and improving competitiveness. The findings indicate that the full costing method yields more precise results and accounts for all production cost components, despite being more complex than other approaches. Consequently, training and simple technological solutions are essential to support MSMEs in adopting this method.
The Impact of COVID-19 on Type 2 Diabetic Patients: An Analysis of Cardiovascular Complications Using Biological Explorations
Authors: Pouki Freddy Saturnin , Boumba Luc Magloire Anicet , Batchy Aladin Atandi , Elenga-Bongo Charley , Ngouma Ange Cerna Malonga , Boyina Gainze , Dussaud Rebecca Frédérique , Takale Parode Ragive , Ahmed Cheick
Published: January 2025

Introduction: The co-occurrence of diabetes and COVID-19 infection poses a significant medical challenge due to the increased risk of serious complications. Infection with SARS-CoV-2, the virus responsible for COVID-19, exacerbates these risks because of the systemic inflammation it causes and the direct and indirect effects of the virus on the cardiovascular system. Objective: The aim of this study was to explore cardiovascular risks in diabetic patients testing positive for COVID-19 in Pointe-Noire, Republic of Congo. Methods: We recruited a total of 206 participants for this study. Biomarkers were quantified from blood samples and sars cov-2 virus was identified using the PCR technique on nasopharyngeal swabs. Results: Analysis of our data shows that the following biological parameters are evidence of cardiovascular complications ESR: OR 1.91(1.84-1.97) p<0.001 DDI: OR 1.01(1.01-1.01) p<0.001, APTT: OR 1.67(1.33-2.09) p<0.001, TG/hdl: OR 1.78(1.48-2.13) p<0.001, CK-MB: OR 1.37(1.17-1.59) p<0.001. There was also a strong correlation between AIP and TG (r =0.86, p<0.001) and inversely with HDL (r= -0.56, p<0.0001). A strong association between AC with LDL (r=0.79, p<0.001) and TC (r=0.68, p<0.001). A strong inverse linear correlation of CRR with HDL (r= -0.79, p<0.001) and positive with TC (r=0.53, p<0.001). A strong correlation coefficient of between CPI with HDL (r=0.69, p<0.001) and negative with CT (r= -0.46, p<0.001) and, an inverse relationship with HbA1c(r= -0.22). Conclusion: The results of our study show that COVID-19 in T2DM can cause cardiovascular complications or deterioration of coexisting cardiovascular disease by direct or indirect mechanisms.
Causes and Consequences of Premarital Sex among Secondary School Students in Southern Ijaw LGA of Bayelsa State
Authors: Ockiya Ebiseighe , Bunu Ebibotei Desire , Maliki Agnes Ebi , Amabebe Alexander Ebimobode
Published: January 2025

This study was carried out to examine the causes and consequences of premarital sex among secondary school students in the Southern Ijaw local government area of Bayelsa State. Specifically, the study examined the factors responsible for secondary school student’s involvement in pre-marital sex and also evaluated the effects of premarital sex. Lastly, the study recommends solutions. The study employed the descriptive survey design, from the responses obtained and analyzed, the findings revealed that pressure, economic reasons, and parental influence are some of the causes of pre-marital sex among secondary school students. Also, some of the effects of pre-marital sex among secondary school students are unplanned pregnancy, school dropout, and Poor academic performance. Lastly, some of the ways to curb pre-marital sex among secondary school students are that parents should provide the necessary materials for their children to discourage premarital sex, health educators should work in collaboration with the curriculum designers in the secondary school education and Sensitization on the effect of pre-marital sex. The study thereby recommends that parents should ensure that useful pieces of information on sexuality are provided for adolescents at home to guide them against being influenced by destructive information from friends and media.
Integrated Use of Coffee Husk Compost and Inorganic Fertilizer Enhances Soil Properties, Coffee Growth and Yield in West Wollega, Ethiopia
Authors: Bikila Takala Bikila x , Chali Gemechu
Published: January 2025

Integrated application of inorganic and organic fertilizers is an important practice to sustainably manage and replenish plant nutrients in agricultural soils. However, determination of the optimum combination of these resources based on soil type and requirement of the crop species and variety is necessary. In this context, a field experiment was conducted at Haru research center to assess the effect of coffee husk compost and NPS fertilizer on soil physicochemical properties, and growth and yield of a released coffee variety (Manasibu) for the area. The treatments consisted of nine combinations of different rates of coffee husk compost and NP fertilizers, and laid out in randomized complete block design with three replications. Soil samples were taken and analyzed for selected physicochemical properties following the standard laboratory procedures. All relevant soil and agronomic data were collected and subjected to Analysis of Variance using SAS package and treatment means were compared at 0.05 probability level using least significant difference test. Results of the study showed that application of coffee husk compost increased soil pH. Moreover, application of coffee husk compost along with inorganic fertilizers increased the contents of organic matter, soil moisture content, total nitrogen, available phosphorus, and CEC. Combined application of higher doses of coffee husk compost and NP fertilizer significantly improved growth of coffee plants. Similarly, combined application of 7.5 t ha-1 of coffee husk compost and 50% of the recommended NP (86 and 38 Kg ha-1 NP respectively) significantly increased clean coffee yield up to 1.78t ha-1. Therefore, it was concluded that the use of 7.5 t ha-1 coffee husk compost and 50% of the recommended NP (86 and 38 Kg ha-1 NP respectively), can be the best integrated soil fertility management option or optimum coffee production in the study area. Nevertheless, in order to come up with a conclusive recommendation, further studies are needed for different soil types and coffee varieties.
Gender-Related Factors and Entrepreneurial Intentions of Undergraduates in Selected Federal Universities in Southwestern Nigeria
Authors: Omotajo Dr. , Arit Julia
Published: January 2025

This study investigates the gender-related factors influencing the entrepreneurial intentions of undergraduates in selected federal universities in Southwestern Nigeria. It explores barriers encountered by both male and female undergraduates, the role of entrepreneurship education in shaping entrepreneurial intentions, and the impact of gender stereotypes. Data were collected via structured questionnaires administered to 500 students across six universities. The results revealed significant gender disparities, with male students exhibiting higher entrepreneurial intentions than their female counterparts, who face additional barriers such as societal expectations, limited access to capital, and pervasive gender stereotypes. Entrepreneurship education positively influences the entrepreneurial intentions of both genders; however, female students require more tailored support to overcome their unique challenges. This study provides insights that can inform the development of gender-sensitive policies and educational programs to foster inclusive entrepreneurship in Nigeria.
Application of H5p in Teaching the Basic Programming Course in the Information Technology Department at Hung Vuong University
Authors: Trung Nguyễn Kiên , Hưng Đỗ Tất , Sơn Lê Hồng , Hảo Nguyễn Thị
Published: January 2025

In the current context, digital transformation is developing rapidly, especially in higher education. This transformation involves changes in teaching methods and improvements in supportive infrastructure to meet the needs of administration, teaching, and learning for students, instructors, and the campus environment. The Digital Education model enables students to access a wealth of diverse learning resources through electronic devices such as computers, tablets, and smartphones. Additionally, the application of information technology and digital transformation in education and training enhances interactivity and practical experience for students and learners. This digital shift in teaching allows instructors to prepare lessons quickly using available templates while leveraging various resources like videos, images, and digital materials. Consequently, it attracts learners and improves teaching effectiveness. In this paper, we discuss the application of information technology, specifically the use of H5P, to create electronic learning materials for the Basic Programming course at Hung Vuong University.
THE INFLUENCE OF DEBT POLICY AND SUSTAINABILITY REPORT ON COMPANY VALUE IN MANUFACTURING COMPANIES LISTED IN THE INDONESIAN STOCK EXCHANGE
Authors: Bilqis Reiva Sativa , Sulfitri Virna
Published: January 2025

Penelitian ini bertujuan untuk menganalisis pengaruh kebijakan utang dan laporan keberlanjutan terhadap nilai perusahaan pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) periode 2021-2023. Kebijakan utang dan laporan keberlanjutan menjadi variabel independen yang diuji untuk melihat dampaknya terhadap nilai perusahaan sebagai variabel dependen. Metode yang diterapkan yaitu regresi logistik menggunakan perangkat lunak SPSS versi 25. Penelitian ini menggunakan pendekatan kuantitatif dengan teknik purposive sampling untuk memilih sampel dari perusahaan manufaktur sektor non-siklikal yang terdaftar di BEI. Hasil penelitian menunjukkan bahwa kebijakan utang memiliki pengaruh positif dan signifikan terhadap nilai perusahaan. Selain itu, laporan keberlanjutan juga ditemukan memiliki pengaruh positif yang signifikan terhadap nilai perusahaan. Kesimpulan penelitian ini adalah bahwa baik kebijakan utang maupun laporan keberlanjutan memiliki peran penting dalam meningkatkan nilai perusahaan
ANALISIS DAMPAK KENAIKAN TARIF PPN 11% TERHADAP PENJUALAN PT. SOKENKO MAJU JAYA
Authors: Tjendana Efvlint , Sulfitri Virna
Published: January 2025

Indonesia yang sedang berada dalam keadaan perekonomian tidak stabil yang disebabkan oleh adanya Pandemi Covid-19, membuat adanya pendapatan negara menjadi menurun drastis, bahkan diramalkan akan masuk kejurang resesi. Agar hal itu tidak terjadi, maka pemerintah mengambil keputusan untuk menormalkan keadaan perekonomian di Indonesia, melalui menaikan tarif PPN 11%. Namun kenaikan tarif PPN ini, terjadinya kenaikan harga jual, sehingga menyebabkan penurunan penjualan yang terjadi pada perusahaan. Penelitian ini menggunakan metode penelitian deksriptif kualitatif, untuk mengetahu bagaimana dampak dari kenaikan tarif PPN 11% terhadap penjualan. Hasil penelitian ini, menunjukan bahwa semakin tinggi tarif PPN, maka harga jual akan secara otomatis naik dan bisa menjadi salah satu faktor penurunan penjualan yang di peroleh dari perusahaan.
Kata Kunci: Pajak, PPN, 11%, Kenaikan, Perbandingan.
PENGARUH GOOD CORPORATE GOVERNANCE, CORCORATE SOCIAL RESPONSIBILITY, DAN KINRJA KEUANGAN TERHADAP NILAI PERUSAHAAN (Studi Pada Perusahaan Manufaktur Sektor Makanan dan Minuman Yang Terdaftar Di Bursa Efek Indonesia (BEI) Tahun 2018-2022)
Authors: Duha Rinumawati , Satiman Satiman
Published: January 2025

This research aims to find out and obtain empirical evidence regarding the influence of Good Corporate Governance, Corporate Social Responsibility and Financial Performance on Company Value in Food and Beverage Manufacturing Companies listed on the BEI in 2018 - 2022. The dependent variable in this research is Company Value, while the variable independent in this research are Good Corporate Governance, Corporate Social Responsibility, and Financial Performance. This research is quantitative in nature and uses associative methods and data comes from company annual reports for the period 2018 - 2022 with panel data regression analysis techniques. The research results in the form of the Good Corporate Governance variable with the Independent Commissioner proxy obtained a prob value of 0.3687 with a coefficient of 0.903491 which shows that Independent Commissioners do not have a significant effect on Company Value. The Good Corporate Governance variable, which is proxied by Institutional Ownership, obtained a prob value of 0.2144 with a coefficient of -3.481297, indicating that Institutional Ownership has no significant effect on Company Value. The Corporate Social Responsibility variable obtained a prob value of 0.2831 with a coefficient of -0.411141 indicating that Corporate Social Responsibility has no significant effect on Company Value. The Financial Performance variable obtained a prob value of 0.0000 with a coefficient of 4.315947 with a positive sign, indicating that financial performance has a significant positive effect on company value.
PENGARUH INFLUENCER VIRTUAL, KETERLIBATAN PELANGGAN, INTERAKSI PARASOSIAL, DAN KREDIBILITAS INFLUENCER PADA KEPUTUSAN PEMBELIAN GENERASI Z
Authors: Tamarima Vena , Slamet Slamet , Putri Puspita Lianti
Published: January 2025

Influencer virtual semakin popular dalam pemasaran digital, terutama di kalangan Generasi Z yang aktif di media sosial. Avatar digital ini memberikan fleksibilitas dalam menyampaikan identitas merek dan meningkatkan efektifitas kampanye. Penelitian ini menganalisis dampak influencer virtual, keterlibatan pelanggan, interaksi parasosial, dan kredibilitas influencer pada keputusan pembelian Generasi Z. Dengan pendekatan kuantitatif eksplanatori, data dikumpulkan melalui survei cross-sectional. Hasilnya menunjukkan bahwa influencer virtual berdampak negative pada keputusan pembelian, sementara keterlibatan pelanggan, interaksi parasosial, dan kredibilitas influencer memiliki pengaruh positif signifikan. Temuan ini menekankan pentingnya optimasi faktor-faktor tersebut dalam strategi pemasaran untuk menarik Generasi Z. Penelitian lebih lanjut diperlukan untuk menguji generasi lain dan faktor seperti kepercayaan merek serta ulasan pelanggan.
ОЧИСТКА ДЕТАЛЕЙ ГРУЗОВИКА ОТ ОСАЖДЕННОЙ ПЕСЧАНО-ГЛИНИСТОЙ СУСПЕНЗИИ
Authors: Храпова Т.Е. , Фадеев И.В. , Глинкин Б.Н. , Лимаренко Н.В. , Мурог И.А.
Published: January 2025

Проблема и цель. Изучить и проанализировать параметры мойки деталей грузовика с использованием искусственного загрязнения из песчано-глинистой суспензии, выявить эффективность удаления загрязнения на различных режимах мойки. Методология. Главным фактором, определяющим долговечность деталей сельскохозяйственной техники является их очистка от загрязнения в процессе использования. Методика исследования основана на осаждении грязевых отложений с заданным составом песчано-глинистой суспензии на наружных поверхностях деталей, количества погружений, температуры воды, частоты вращения вала редуктора лабораторной установки. Результат. Эффективность мойки деталей определяется параметрами процесса очищения с учетом температуры используемой воды и частоты вращения вала редуктора двигателя, приводящего в движение воду при промывке деталей, и состава загрязнения. Заключение. Проведённые исследования удаления осажденной на детали песчано-глинистой суспензии показали, что процесс описывается нелинейной зависимостью, причём, с увеличением температуры и частоты вращения вала редуктора эффективность смыва грязевых отложений с детали возрастает.

Problem and purpose. Problem and purpose: to study and analyze the parameters of washing truck parts using artifcial pollution from sand-clay suspension, to identify the efectiveness of removing pollution in various washing modes. Methodology. Тhe main factor determining the durability of agricultural machinery parts is their cleaning from contamination during use. The research methodology is based on the deposition of mud deposits with a given composition of sand-clay suspension on the outer surfaces of parts, the number of dives, water temperature, and the rotational speed of the gearbox shaft of the laboratory installation. Result. Тhe efciency of washing parts is determined by the parameters of the purifcation process, taking into account the temperature of the water used and the speed of rotation of the gear shaft of the engine that drives the water when washing parts, and the composition of contamination. Conclusion. The conducted studies of the removal of the sand-clay suspension deposited on the part showed that the process is described by a nonlinear dependence, moreover, with an increase in temperature and speed of rotation of the gearbox shaft, the efciency of fushing mud deposits from the part increases.
АВТОМАТИЗАЦИЯ РАБОТЫ ДВУХРЕАКТОРНОЙ УСТАНОВКИ ДЛЯ ПОЛУЧЕНИЯ БИОГАЗА ИЗ ОТХОДОВ АГРОПРОМЫШЛЕННОГО КОМПЛЕКСА
Authors: Оковитая К.О. , Макаренко В.Г. , Суржко О.А.
Published: January 2025

Проблема и цель. В статье изучена проблема автоматизации непрерывной работы двухреакторной биогазовой установки в соответствии с требованиями наилучших доступных технологий. Методология. Разработан алгоритм автоматизации работы двухреакторной биогазовой установки непрерывного действия и модернизация системы управления. Результаты. Проведены исследования автоматизации технологического процесса анаэробного сбраживания биомассы с получением биогаза. Разработана функциональная схема автоматического технического комплекса управления работой двухреакторной биогазовой установки. Заключение. Применение разработанной схемы автоматизации позволит оперативно, без участия оператора, регулировать параметры процессов гидролиза и метаногенеза, проходящих при разных температурах, таких как уровень субстрата ±0,3 м, рН ±0,1, температура ± 1° C .Автоматизация перекачивания субстрата через теплообменник и работы мешалок позволит более полно реализовать метановый потенциал субстратов за 25 суток.

The article examines the problem of automating the continuous operation of a two-reactor biogas plant in accordance with the requirements of the best available technologies. Problem and purpose. An algorithm for automating the operation of a two-reactor biogas plant of continuous operation and upgrading the control system has been developed. Methodology. Studies have been conducted on the automation of the technological process of anaerobic digestion of biomass to produce biogas. A functional diagram of an automatic technical control complex for the operation of a two-reactor biogas plant has been developed. Results. Studies have been conducted on the automation of the technological process of anaerobic digestion of biomass to produce biogas. A functional diagram of an automatic technical control complex for the operation of a two-reactor biogas plant has been developed. Conclusion. The developed system for automatic control of the operation parameters of a two-reactor biogas plant for the production of biogas from organic waste. The automatic control system makes it possible to maximize the biogas potential of organic waste.
Features of interaction between selective lipid metabolites and immune system signaling molecules in patients with asthma
Authors: Vitkina T. I. , Kovalenko I. S. , Bocharova N. V. , Novgorodtseva T. P. , Ermolenko E. V.
Published: January 2025

Introduction. Lipid metabolism is a key component in many pathophysiological processes, and its disruption can play a significant role in the development of chronic inflammation in asthma. Aim. To determine the nature of the interaction between fatty acids (FAs) and their derivatives with cytokine parameters of the immune system and their contribution to systemic inflammation in patients with asthma. Materials and methods. The spectrum of FAs in the plasma of patients with asthma was analyzed using gas chromatography-mass spectrometry. Levels of endogenous fatty acid ethanolamides (NAEs) were measured using high-performance liquid chromatography with mass spectrometry. Cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA). The degree of interaction between the parameters was assessed using systemic analysis based on the integral coupling index (D). Results. It was established that the immune system response was most strongly associated with the relative content of n-6 polyunsaturated fatty acids. Modification of the FA composition was most significantly linked with interleukins (IL) 17A, 10, 4, and 6. Endogenous NAEs—arachidonoylethanolamide (AEA, 20:4n6) and docosahexaenoylethanolamide (DHEA, 22:6n3)—showed significant involvement in cytokine regulation in mild asthma. NAE 20:4n6 had the strongest association with IL-17A, interferon-γ, tumor necrosis factor (TNF)-α, and IL-2; NAE 22:6n3 was associated with IL-17A, IL-6, and TNF-α. Conclusion. The study established the contribution of disturbances in trigger parameters of lipid metabolism to systemic inflammation. Modification of FA composition and disruption of the synthesis of their mediators lead to dysregulation of the cytokine network of the immune system, which may contribute to the development and chronicity of systemic inflammatory reactions in patients with asthma.
Lipid rafts and their role in altering monocyte properties in the blood of women who had COVID-19 during the third trimester of pregnancy
Authors: Andrievskaya I. A. , Ustinov E. M. , Lyazgyan K. S.
Published: January 2025

Introduction. Current literature widely addresses issues related to the pathogenesis of COVID-19 during pregnancy. However, the problem of dysfunction in the monocyte/macrophage system in pregnant women, particularly concerning the influence of changes in the lipid membrane microenvironment caused by SARS-CoV-2, remains unresolved. Aim. To conduct a comparative study and explore the association of lipid rafts with the expression of CD receptors on monocytes involved in forming the immune response in women who had COVID-19 during pregnancy. Materials and methods. The study included women with mild (n = 25) and moderate (n = 27) severity of COVID-19 in the third trimester of pregnancy, and 25 women not infected with SARS-CoV-2 during pregnancy. Using flow cytometry, lipid rafts on blood monocytes were identified by the intensity of the cholera toxin B-subunit (CTB)/ganglioside GM1 complex formation, as well as the expression of Fcγ receptor II (CD32), mannose receptor (CD206), tumor necrosis factor receptors type 1 (TNFR1) and type 2 (TNFR2), interleukin 17 receptor (IL17R), and TNF-related apoptosis-inducing ligand (TRAIL). Lipid raft microscopy was performed using a fluorescent microscope. Results. An increase in the distribution density and number of rafts in the monocyte membrane was established, which were 1.6 times higher (p < 0.001) in moderate disease severity compared to mild cases. The expression levels of CD206 increased by 1.8 times (p < 0.001), CD32 by 1.05 times (p < 0.05), TNFR1 by 1.2 times (p < 0.001), IL17R by 1.7 times (p < 0.001), and TRAIL by 1.4 times (p < 0.001) compared to mild disease. No differences in TNFR2 expression were found between subgroups (p = 0.781). A direct correlation was identified between lipid raft expression levels and CD206 (ρ = 0.70, p < 0.01), CD32 (ρ = 0.77, p < 0.01), TNFR1 (ρ = 0.63, p < 0.01), IL17R (ρ = 0.60, p < 0.01), and TRAIL (ρ = 0.70, p < 0.01). An inverse correlation was also established between the gestational age at delivery and the expression of rafts (ρ = -0.53, p < 0.01), CD206 (ρ = -0.36, p = 0.008), and CD32 (ρ = -0.32, p = 0.02). However, the gestational age at the time of illness was not associated with changes in the expression of lipid rafts and CD receptors. Conclusion. In women who had COVID-19 during the third trimester of pregnancy, monocytes predominantly exhibit a pro-inflammatory phenotype expressing increased amounts of pre-activation markers CD206 and CD32, as well as cytokine receptors TNFR1, IL17R, and TRAIL. It can be hypothesized that the increased expression of CD206, CD32, and IL17R—which directly correlated with the number of lipid rafts—may be directly related to monocyte activation and, thus, to the severity of the infection and the development of complications during pregnancy.
The role of 8-isoprostane and 15-hydroxyeicosatetraenoic acid in the pathogenesis of early pregnancy loss in COVID-19
Authors: Ishutina N. A. , Andrievskaya I. A. , Dovzhikova I. V. , Kutepova O. L.
Published: January 2025

In recent years, the role of oxidative stress and oxylipins in the pathogenesis of various diseases, including those affecting the female reproductive system and pregnancy complications, has been actively discussed. However, the role of 8-isoprostane and 15-hydroxyeicosatetraenoic acid (15-HETE) in the pathogenesis of pregnancy loss during COVID-19 has not been definitively established. Aim. To analyze the levels of 8-isoprostane and 15-HETE in peripheral blood and assess their prognostic significance in early pregnancy loss during COVID-19. Materials and methods. The study involved the main group of 48 women with a confirmed diagnosis of moderate COVID-19 (community-acquired pneumonia) in the first trimester (6–9 weeks). The control group consisted of 45 pregnant women who had not had COVID-19 previously and at the time of examination. The levels of 8-isoprostane in peripheral venous blood were measured using Cayman Chemical (USA) reagent kits, and 15-HETE was measured using Enzo 15(S)-HETE ELISA kits (USA) through an enzyme-linked immunoassay (ELISA). Results. Patients with moderate COVID-19 exhibited a significant increase in 8-isoprostane levels to 379.27±9.04 pg/mL (p<0.001) and 15-HETE to 3.66±0.12 ng/mL (p<0.001), compared to the control group values of 178.3±1.40 pg/mL and 1.57±0.06 ng/mL, respectively. To analyze the selected evaluation criteria, a discriminant function with a probability of differences of at least 95% was determined by deriving a discriminant equation, which for this study was as follows: PI = -59.765 + 0.261 × 8-isoprostane + 4.798 × 15-HETE, where PI is the prognostic index with a threshold value of 3.027. A PI equal to or greater than 3.027 indicated a risk of pregnancy loss in women with moderate COVID-19, while a PI lower than this threshold predicted a normal course of the first trimester of gestation. Conclusion. These findings suggest that elevated levels of 8-isoprostane and 15-HETE in women with moderate COVID-19 are pathologically significant in the development of early pregnancy loss.
Infectious complications during programmed therapy for multiple myeloma
Authors: Solovkova N. R. , Voitsekhovsky V. V.
Published: January 2025

Introduction. Monitoring infectious complications during the programmed therapy of hematological malignancies remains a critical issue in modern hematology. Aim. To examine the frequency and nature of infectious complications in patients with multiple myeloma (MM) treated at the Irkutsk Regional Clinical Hospital from 2016 to 2023. Materials and methods. A total of 450 medical records of MM patients who underwent programmed chemotherapy (CT) from 2016 to 2023 were analyzed. Among these, 213 patients (47%) were diagnosed with various infectious complications. These patients were divided into two groups: Group 1 consisted of 100 patients who received CT from 2016 to 2019, while Group 2 included 113 patients treated from 2020 to 2023. Results. The most common infectious complications associated with MM were bacterial pneumonia (41% in 2016-2019 and 18% in 2020-2023), fever of unknown origin (20% in 2016-2019 and 22% in 2020-2023), urinary tract infections (20% in 2016-2019 and 8.8% in 2020-2023), cytomegalovirus (CMV) infection (9% in 2016-2019 and 18.5% in 2020-2023), and in 2020-2023, the emergence of novel coronavirus infection (observed in 17% of MM patients). The majority of infectious complications occurred during the remission induction phase. A significant decrease in bacterial pneumonia (p<0.001) and urinary tract infections (p=0.020) was observed in 2020-2023 compared to 2016-2019, while an increase in CMV infection was noted (p=0.045). Other infectious complications, including gastrointestinal infections, mucositis, herpes infections, and skin and ENT infections, were infrequently reported during the study period. Conclusion. The study revealed new data that can be used to predict the development of infectious complications at various stages of programmed therapy for MM and to formulate effective preventive measures in clinical practice.
Possible role of M-CSF and GM-CSF in the pathogenesis of chronic obstructive pulmonary disease
Authors: Sugaylo I. Yu. , Naumov D. E. , Gassan D. A. , Kotova O. O. , Sheludko E. G. , Sinyuk A. A.
Published: January 2025

Introduction. Granulocyte-macrophage (GM-CSF) and macrophage (M-CSF) colony-stimulating factors are produced by various cells and regulate the proliferation and differentiation of monocytes and macrophages. Concentrations of these substances may vary significantly in many diseases including chronic obstructive pulmonary disease (COPD). Aim. To analyze the concentrations of GM-CSF and M-CSF in the blood plasma of COPD patients and individuals without bronchial obstruction and to determine the patterns of change in these factors in COPD. Materials and methods. The study included 53 smokers with COPD and 24 subjects without bronchial obstruction of which 46% were smokers. Parameters of lung function were measured by spirometry. The concentrations of GM-CSF and M-CSF were determined in the blood plasma using enzyme-linked immunosorbent assay. Cytokines (interleukin (IL)-4, IL-2, IL-1β, tumor necrosis factor (TNF)-α, chemokine C-C motif ligand (CCL) 2, C-X-C chemokine (CXCL)-10, IL-17A, IL-6, IL-10, interferon (IFN)-γ, IL-12p70, IL-8) were determined by multiplex immunofluorescence analysis. Results. The level of M-CSF was significantly reduced in patients with COPD compared to the control group (0.99 (0.39-2.10) pg/ml vs. 2.18 (0.55-3.43) pg/ml, p= 0.04). The median value of GM-CSF, on the contrary, was higher in COPD, although the differences with the control group were not significant (0.57 (0.0-2.49) pg/ml vs. 0.28 (0.0-1.81) pg/ml, p=0.73). The GM-CSF/M-CSF ratio was 0.17 (0.0-2.30) in patients with COPD and 0.15 (0.0-0.80) in those without bronchial obstruction (p=0.85). Concentrations of M-CSF and GM-CSF did not correlate with each other, and were also not associated with age, smoking index, and lung function parameters. Direct correlations were revealed between GM-CSF and percentage of circulating classical monocytes in COPD (ρ=0.38, p=0.008). Conclusion. Considering the important role of M-CSF in the differentiation of anti-inflammatory M2 macrophages, a decrease in the level of this factor may be associated with pro-inflammatory cell polarization in COPD.
Indicators of oxidative homeostasis and genotoxicity in patients with asthma under exposure to solid suspended atmospheric particulate matter
Authors: Kondratyeva E. V. , Vitkina T. I.
Published: January 2025

Introduction. Parameters that characterize the intensity of peroxidation processes and genotoxicity in individuals with asthma, including under the influence of unfavourable environmental factors, can serve as indicators of the disease course. Therefore, there is a need to detail these parameters in asthma patients of different severity and control levels. Aim. To establish the characteristics of disruptions in oxidative homeostasis and genomic apparatus damage in individuals with mild-to-moderate asthma under the in vitro exposure to solid suspended atmospheric particulate matter (SPM). Materials and methods. An in vitro study included 244 asthma patients and 60 conditionally healthy individuals. Model suspensions (MS) simulating multicomponent atmospheric air pollution were used as the exposure load. We investigated total antioxidant activity (AOA), levels of malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), thioredoxin-1 (Trx-1), total glutathione (GSH), and oxidized glutathione (GSSG). Ratios of MDA/AOA and GSH/GSSG were calculated. The effects of SPM are presented as indices reflecting the parameters under the influence of MS and without it. Results. In moderate asthma, more pronounced changes in oxidative homeostasis indicators were registered under SPM exposure compared to mild asthma. In controlled asthma, the maximum differences in indices between groups with mild and moderate severity were observed in the levels of GSSG (1.6-fold increase) and Trx-1 (1.3-fold increase). In partially controlled asthma, the greatest changes were found in the MDA/AOA ratio (2.7-fold increase) and 8-OHdG levels (1.6- fold increase). Conclusion. As asthma severity worsens, there is an increase in oxidative damage to bioorganic molecules and the initiation of genomic damage, which activates the thioredoxin link of the antioxidant system responsible for repairing damaged DNA. Under SPM exposure, more pronounced disruptions of oxidative homeostasis and increased genotoxicity occur with asthma severity, despite the stimulation of reparative processes. Significant elevations in 8-OHdG and Trx-1 levels with increasing asthma severity and SPM exposure may indicate the potential use of these markers to assess disease progression in technogenic environmental conditions.
MENANAMKAN NILAI-NILAI KEWIRAUSAHAAN SISWA MELALUI BAZAR NUSANTARA DENGAN PENGOLAHAN MAKANAN TRADISIONAL
Authors: Ayu Pramoda Wardhani Dyah , Rahmadani Hana Vidya Ajeng , Ningrahayu Agita Dila Septi Restya
Published: January 2025

Kegiatan bazar di sekolah dasar menjadi salah satu upaya efektif dalam mengenalkan keberagaman kuliner Nusantara kepada siswa sejak dini. Bazar Nusantara dengan bahan dasar ubi, ketan, dan singkong dirancang untuk mengedukasi siswa mengenai kekayaan bahan pangan lokal dan mendorong mereka untuk mengapresiasi pangan tradisional. Artikel ini membahas pelaksanaan bazar yang melibatkan siswa dalam persiapan, pembuatan, dan penjualan berbagai olahan makanan berbahan dasar ubi, ketan, dan singkong, seperti getuk, klepon, dan lemet. Selain itu, kegiatan ini juga memperkenalkan siswa pada konsep kewirausahaan sederhana, nilai kebersamaan, dan pelestarian budaya melalui kuliner lokal. Hasil evaluasi menunjukkan bahwa siswa tidak hanya antusias dan kreatif dalam kegiatan ini, tetapi juga memperoleh pemahaman mengenai pentingnya bahan pangan lokal yang sehat dan ramah lingkungan. Dengan demikian, kegiatan ini diharapkan dapat menjadi contoh praktik pendidikan yang mendukung pengenalan budaya dan penguatan karakter siswa
PENINGKATAN KEMAMPUAN MENULIS ARTIKEL ILMIAH SISWA SMA MELALUI PELATIHAN BERBASIS KOMPETENSI
Authors: Candra Vinalistyosari Risca
Published: January 2025

Kemampuan dalam menulis artikel ilmiah merupakan keterampilan yang sangat penting bagi siswa SMA terutama dalam menghadapi tantangan global yang mengutamakan kemampuan literasi yang tinggi. Artikel ini membahas sebuah program pengabdian kepada masyarakat yang berupa pelatihan penulisan artikel ilmiah yang diselenggarakan untuk siswa SMA di Kecamatan Banyuputih, Kabupaten Situbondo. Program pelatihan ini diterapkan dengan pendekatan berbasis kompetensi yang mencakup tahapan perencanaan, pelaksanaan, serta evaluasi. Berdasarkan hasil survei dan studi kasus, terlihat adanya peningkatan signifikan dalam pemahaman siswa mengenai struktur artikel, penggunaan tata bahasa akademik, serta penerapan teknik penulisan yang sesuai dengan standar internasional.
UPAYA PENINGKATAN PENGETAHUAN ANAK USIA SEKOLAH TENTANG MENCUCI TANGAN DI SDN I IDI RAYEUK
Authors: Juliana Nanin , Lindawati Lindawati
Published: January 2025

Salah satu tindakan sanitasi dengan membersihkan tangan dan jari jemari dengan menggunakan air ataupun cairan lainnya oleh manusia dengan tujuan untuk menjadi bersih, sebagai bagian dari ritual keagamaan, ataupun tujuan-tujuan lainnya. Permasalahan yang juga banyak timbul adalah minimnya pengetahuan anak sekolah dasar tentang mencuci tangan karena akses yang terbatas. Tujuan kegiatan ini adalah melakukan pendidikan kesehatan sebagai upaya peningkatan pengetahuan anak usia sekolah tentang kesehatan reproduksi. Tujuan kegiatan ini adalah melakukan pendidikan kesehatan sebagai upaya peningkatan pengetahuan anak usia sekolah tentang mencuci tangan. Kegiatan ini dilakukan oleh tim dosen dan mahasiswa universitas nagoya indonesia  sebagai bentuk kegiatan pengabdian masyarakat untuk meningkatkan pengetahuan anak usia sekolah tentang mencuci tangan. Mitra kegiatan pengabdian kepada masyarakat ini adalah Sekolah Dasar Negeri Idi Rayeuk. Hasil kegiatan ini mendapatkan respons positif dari peserta sasaran. Hasil yang didapat yaitu sebelum diberikan pendidikan kesehatan, pengetahuan peserta berada pada kategori cukup sebanyak 71% dan setelah diberikan pendidikan kesehatan berada pada kategori baik sebanyak 49%.
PENGUATAN KETERAMPILAN KOMUNIKASI SISWA SMA DI SURABAYA MELALUI PELATIHAN KOMUNIKASI ASERTIF
Authors: Tanoto Sherly Rosalina
Published: January 2025

Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan keterampilan komunikasi siswa SMA di Surabaya yang menghadapi tantangan dalam membangun komunikasi interpersonal akibat tingginya penetrasi teknologi digital. Melalui pendekatan berbasis aktivitas, pelatihan ini dirancang untuk mengajarkan keterampilan komunikasi asertif, seperti “I Statements” dan “Hamburger Feedback”, guna membantu siswa mengelola konflik, menyampaikan perasaan secara konstruktif, dan membangun hubungan interpersonal yang sehat. Metode pelaksanaan melibatkan aktivitas interaktif, seperti simulasi, diskusi kelompok, dan latihan komunikasi verbal, dengan fokus pada penerapan teknik komunikasi yang relevan dalam kehidupan sehari-hari. Hasil kegiatan menunjukkan adanya peningkatan signifikan dalam kepercayaan diri siswa saat berkomunikasi di depan umum, kemampuan memberikan umpan balik yang sopan dan efektif, serta pemahaman mereka tentang pentingnya mendengarkan aktif dalam percakapan. Program ini diharapkan dapat menjadi solusi yang relevan dan berkelanjutan dalam membantu siswa mengatasi tantangan komunikasi di era digital serta mempersiapkan mereka untuk berpartisipasi secara aktif dalam lingkungan akademik dan sosial.
MENUMBUHKAN KESADARAN ORANG TUA (WALI MURID) DI PAUD SEKAR JAMBI PADEMAWU DALAM MENANAMKAN NILAI MORAL ANAK USIA DINI MELALUI PARENTING EDUCATION
Authors: Anjarani Devie Reztia , Zuhri Muhammad Darrin , Hasbullah Hasbullah , Aristin Rini , Erfany Muhammad Iqbal
Published: January 2025

Pengabdian ini bertujuan untuk menumbuhkan kesadaran orang tua (wali murid) di PAUD SEKAR JAMBI Pademawu dalam menanamkan nilai-nilai moral pada anak usia dini melalui program parenting education. Pendidikan moral pada anak usia dini memegang peranan penting sebagai landasan pembentukan karakter di masa depan. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan pendekatan partisipatif. Data diperoleh melalui observasi, wawancara, dan dokumentasi yang melibatkan guru, orang tua, dan anak didik. Hasil penelitian menunjukkan bahwa program parenting education mampu meningkatkan pemahaman orang tua tentang pentingnya nilai moral seperti kejujuran, tanggung jawab, dan sikap saling menghormati. Selain itu, keterlibatan aktif orang tua dalam kegiatan parenting, seperti seminar, diskusi kelompok, dan simulasi praktik mendidik, terbukti efektif dalam membangun kesadaran dan komitmen mereka untuk menanamkan nilai moral pada anak di lingkungan keluarga. Dengan dukungan berkelanjutan dari lembaga pendidikan dan kolaborasi erat antara guru dan orang tua, program ini diharapkan dapat menciptakan generasi anak yang bermoral dan berkarakter kuat.
UPAYA PENCEGAHAN STUNTING MELALUI EDUKASI OLAHAN PUDING DAUN KELOR
Authors: Rizqi Angguliyah , Imalluroseh Imalluroseh
Published: January 2025

Stunting merupakan masalah signifikan yang disebabkan oleh nutrisi yang tidak mencukupi. Kondisi ini bermanifestasi ketika seorang anak mengalami gangguan pertumbuhan, menghasilkan tinggi badan yang lebih rendah dari standar yang ditetapkan untuk usia mereka. Terjadinya kondisi ini terutama disebabkan oleh kekurangan nutrisi yang diperlukan yang berkepanjangan. Dalam konteks Indonesia, isu stunting lazim; Program Kerja ini menekankan inisiatif pendidikan yang ditujukan untuk pencegahan stunting dan penerapan praktik manajemen produk pangan berbasis moringa, khususnya dengan fokus pada puding, yang dilakukan dengan Ibu -Ibu PKK Desa Babaan. Kegiatan dilaksanakan dalam tiga tahap yang berbeda yaitu metode ceramah atau sosialisasi tentang pencegahan dan penanggulangan stunting serta penanggulangan gizi seimbang pada anak balita dan pembuatan puding kelor dengan cara pengolahannya dan diakhiri dengan pembagian puding dari bahan utama daun kelor. Hasil dari kegiatan pengabdian masyarakat ini menunjukkan peningkatan yang signifikan dalam pengetahuan dan pemahaman akan khasiat olahan daun kelor bagi Ibu PKK yang ditujukan untuk pencegahan stunting.
Perbandingan Prediksi Saham BTPN Dengan BBRI Menggunakan LSTM(Long Short Term-Memory)
Authors: Handika Bayu Dwi , Sugianto Sugianto
Published: January 2025

Salah satu opsi yang banyak diminati investor adalah saham perbankan. Rephrase.Pergerakan harga saham berubah dengan cepat. Oleh karena itu, perlu dilakukan prediksi harga saham untuk meminimalkan risiko kerugian. Tujuan dari penelitian ini adalah untuk menguji kinerja model memori jangka pendek panjang (LSTMs) dalam memprediksi harga saham di sektor perbankan. Data yang digunakan adalah data harga penutupan harian perbankan pada tanggal 16 April 2001 sampai dengan tanggal 30 September 2022. Tahap eksplorasi meliputi (1) entri data untuk memperoleh data harga penutupan dan (2) praproses data untuk mencari nilai data yang hilang. (3) Pemisahan data yaitu pemisahan data menjadi data latih dan data uji dengan perbandingan 80:×20.(4) Normalisasi data.Artinya, mengubah data ke skala yang sama. (5) Rekonstruksi data untuk mengubah data ke dalam format array. (6) Gunakan data pelatihan untuk melatih model yang terdiri dari dua lapisan LSTM dan satu lapisan. (7) Uji model pada data uji menggunakan MAE dan evaluasi hasil prediksinya. Berdasarkan hasil penelitian, nilai uji MAE BTPN sebesar 0,014443 dan nilai uji MAE BBRI sebesar 0,014066.