bluuebunny/crossref_metadata_2025 huggingface dataset:
KAJIAN PENGGUNAAN CIPROFLOXACIN TERHADAP HISTOLOGI INSANG DAN HATI IKAN BOTIA (Botia macracanthus, Bleeker) YANG DIINFEKSI BAKTERI Aeromonas hydrophila
Authors: S Sukarni , Sukmono Tedjo
Published: April 2019

Aeromonas hydrophila mampu menyebabkan terjadinya infeksi dan kematian ikan botia dalam waktu yang relatif singkat pada konsentrasi yang tinngi, terbukti dengan konsentrasi 108 sel/ml sudah mampu menyebabkan 50% ikan uji mati.  Hasil pengamatan histopatologi pada ikan terinfeksi memiliki ginjal yang mengalami degenerasi hyaline, vakuola yang disebabkan glomerulus yang mengalami lisis dan kemudian hancur, nekrosis pada glomerulus, terdapat banyak koloni bakteri A.hydrophila didalam ginjal, terjadi infiltrasi limfosit. Pada bagian hati terlihat sel hati tidak terlihat jelas karena tertutup akibat infiltrasi limfosit dan koloni bakteri A.hydrophila yang sangat banyak, nekrosis yang menyebabkan vakuola, terdapat infeksi sekunder bakteri yang belum teridentifikasi, serta terjadi cloudy swelling. Pada bagian insang nekrosis pada lamella primer yang menyenbabkan vakuola, kongesti pada lamella primer dan edema pada lamella sekunder, infiltrasi limfosit, poliferasi sel/ fusi lamella serta hyperplasia pada lamella primer.  pada ikan botia yang terinfeksi A.hydrophila tetapi kemudian diobati, pada ginjal mengalami perbaikan glomerulus dan kapsula bowman sehingga terlihat jelas, tubuli berbentuk seperti donat dengan corak titik dan garis, tidak ada lagi nekrosis dan vakuola, tidak diketemukan lagi koloni bakteri, terjadi perbaikan hyaline yang mengalami degenerasi, jaringan hematopoietic (pembentuk sel-seldarah merah) terlihat jelas dengan inti yang bulat. Pada bagian hati tidak ditemukan lagi koloni bakteri A.hidrophila dan bakteri sekunder lainnya sehingga hepatosit terlihat jelas dengan bentuk polyhedral dengan inti 1-2, jumlah eritrosit terlihat normal, karena tidak ada lagi infiltrasi limfosit,  akan tetapi masih terdapat penyumbatan pada vena centralis yang ditandai dengan vena centralis dipenuhi oleh eritrosit. Pada Insang tidak ada lagi nekrosis dan vakuola pada lamella primer sehingga jaringan terlihat solid, ditemukan infeksi sekunder parasit Monogenea sp, tidak ada lagi infiltrasi limfosit, lapisan epithelium terlihat 1-2 lapis, tidak ada lagi edema dan fusi lamella sehingga lamella tampak jelas dengan ukuran panjang yang bervariasi.
Kamuflase dan Strategi Antipredasi Pada Kepiting Hantu Ocypode (Weber, 1795) di Pantai Congot, Kulonprogo, Yogyakarta
Authors: Pratiwi Eka Mulia , Susilohadi Susilohadi
Published: April 2019

Antipredation adalah salah satu jenis adaptasi yang dilakukan oleh hewan mangsa dalam menghadapi predator, baik yang menghindar maupun bertarung. Strategi antipredasi yang paling sering dilakukan oleh beberapa hewan adalah dengan menipu para predator, salah satunya dengan kamuflase. Dalam kepiting hantu yang disamarkan dilakukan dengan menggunakan teknik pencocokan latar belakang, yang mengubah warna tubuh mereka dan mencocokkannya dengan warna lingkungan mereka dengan menyesuaikan konsentrasi dan dispersi pigmen di chromatophore (Davies, 2013). Selain kamuflase, kepiting hantu juga menjadikan lubang sebagai tempat persembunyian pemangsa. Dengan mengacu pada strategi kamuflase dan antipredasi pada Kepiting Hantu (Ocypode), perlu dilakukan penelitian yang meneliti perilaku strategi antipredasi yang mencakup kamuflase dan arsitektur liang kepiting hantu di Pantai Congot, Kulonprogo, Yogyakarta. Metode yang digunakan dalam penelitian ini termasuk mengambil data potret cahaya tampak menggunakan Ocypode dan lingkungannya untuk menganalisis nilai RGB, kemudian membandingkan komposisi RGB dengan spesimen dan lingkungannya dengan indeks Euclidean Distance. Selain itu, pengumpulan data arsitektur liang menggunakan bubuk gypsum disterilkan dengan air dan kemudian dibiarkan kering dan kemudian hasil cetakan diukur dan dianalisis. Hasil yang diperoleh antara lain nilai Euclidian Distance sebesar 0,12 yang menunjukkan bahwa warna pada karapas sesuai dengan warna lingkungan. Selain itu, ada 29 cor arsitektur liang yang terdiri dari 20 bentuk-I, 2 bentuk-J, 2 bentuk-L, 1 bentuk spiral 3-Y, dan 1 bentuk kompleks.
Proposals for classification and evaluation of land degradation in Latvia
Authors: Jankava Anda , Parsova Velta , Laizane Eva , Berzina Maija , Palabinska Aina
Published: April 2019

Land degradation is one of the most pressing problems ensuring sustainable use of land. In order to provide a clear understanding of land degradation and its risks, as well as to implement unified measures for prevention of land degradation in Latvia, the Land Management Law came into force in 2015. It individually defines the concepts of land and soil degradation, thus separating them from each other, as well as clarifying the term “degraded territory”. However, despite these solutions in the regulatory framework of the land degradation, till now criteria for identifying land degradation have not been developed and approved, therefore their determination is very subjective and not comparable between municipalities and at the state level. The aim of the article is to develop and approbation degradation criteria for assessing land degradation in particular territory. In the article, based on the author's previous studies on the classification of land degradation, characterised one type of land degradation - the abandoned agricultural and forestry activity territory, as well as proposed subdivision of criteria classification into three levels – low, medium and high. As result of the study, it was concluded that the classification of degraded territories into three degradation levels is justified for the purpose of more objective identification and evaluation of land degradation.
Possibilities Use to Selected Methods of Spatial Data Mining in Demographic Data Analytics
Authors: Kurowska Krystyna , Kietlinska Ewa , Kryszk Hubert
Published: April 2019

The main purpose of data mining in private and public sector institutions is to process and analyse data with the aim of generating reliable information for decision-making. Decision-making performance is determined by the availability of the relevant data and the user’s ability to adapt that data for analytical purposes. The popularity of spatial statistical tools is on the rise owing to the complexity of the analysed factors, their variation over time and their correlations with the spatial structure. Popular models should be applied in demographic analyses for the needs of the spatial planning process. The availability of high-resolution data and accurate analytical tools enhances the value of spatial analyses, and the described models can be universally applied to support the decision-making process. The aim of this study was to present the applicability of selected spatial statistical models for analysing demographic data in the planning process and to identify the main advantages of these models.
Use of Geospatial Analysis Methods in Land Management and Cadastre
Authors: Myslyva Tamara , Sheluto Bronislava , Kutsaeva Olesya , Naskova Svetlana
Published: April 2019

The possibilities of using the geospatial analysis methods for visualizing land monitoring data and modelling the spatial distribution of the main agrochemical soil indicators are discussed in the article. The research was conducted within the limits of land use of RUP “Uchkhoz BGSHA” (Republic of Belarus, Mogilev region, Goretsky district). The total area of the surveyed territory was 3187.0 hectares. The geospatial analysis of the spatial distribution of humus, mobile phosphorus, mobile potassium and pHKCl was carried out using the Geostatistical Analyst module of the ArcGIS software. Semivariograms were used as the main tool for studying the structure of the spatial distribution of agrochemical indicators. The exponential function was identified as the best variogram model, the type of the circle was standard, the type and the number of sectors was 4 with a displacement of 450, and the lag was 200 meters. The interpolation accuracy was determined from the mean error (ME), mean square error (RMSE) and standard error (RMSS). The universal kriging method was used to perform the forecast and visualize the spatial distribution of agrochemical indicators. The multivariate analysis was performed using the functionality of the Raster Calculator tool, Principal Component analysis and Maximum Likelihood Classification. The search and determination of areas of sites with the most optimal agrochemical indicators were carried out by the multifactor analysis in the GIS environment. Calculation of the area of each circuit within the limits of working parcels was carried out using the utility "Zone Statistics".
Research of Compatibility and Systemity of Land Management Terminology
Authors: Trevoho Ihor , Riabchii Valery , Riabchii Vladyslav
Published: April 2019

The analysis results of common terms in land management and their interpretations in normative-legal acts of Ukraine are presented. It have been established collisions and significant differences in the wording of even such common terms as a land parcel, a boundary of land parcel, a size of land parcel, etc. The purpose of the study is to identify collisions and contradictions of some key terms used in land surveying and geodetic works, as well as development of concrete proposals for improving and perfection the relevant terms. For this purpose, the following tasks were set and solved: analysis of regulatory legal acts of Ukraine concerning the conceptual apparatus of land management, systematization and generalization of substantiation results of the relevant terms correction need, development of proposals taking into account works content on land management and geodetic works for information provision of the State Land Cadastre. In the course of the study, the comparative method of analysis and the systematization of inconsistencies in the current normative legal acts of Ukraine regarding the terms and their interpretation are used. During the proposals development, known approaches "from general to partial" and vice versa were used. The established disadvantages do not allow unambiguously interpreting and performing such important work as geodetic setting or restoration of the land parcels boundaries, resolution of land disputes between adjacent users of land parcels. Completed summaries of content and wording of the relevant terms justify a need for correction of the terms and additions to their definitions. It was set the features of each term. As a result of integrated approach to solution of the existing problem and systematization of established differences, the general wording and detailed specification of the analyzed terms interpretations are proposed. Knowledge of technological stages for geodetic and land management works provided an opportunity to improve the geodetic information support of the State Land Cadastre. The proposals for correction of the studied terms eliminate existing contradictions, provide an unambiguous interpretation of land management terminology, which leads to the exact execution of geodetic and land management works, and, accordingly, obtaining reliable information for the State Land Cadastre.
Directed myogenic reprogramming of differentiated cells
Authors: Indeikin F. A , Mavlikeev M. O , Deev R. V
Published: April 2019

A morphological manifestation of myopathies is progressive lesion of muscular tissue with it substitution by connective tissue which makes it necessary to compensate cell loss. To date, methods which can replenish a cell pool in an affected muscle are absent. A method which potentially can correct manifestations of such diseases is a direct cell reprogramming. The undoubted advantage of this approach is an absence of necessity of returning cell in a pluripotent stage which allows to use it in vivo. The great experience in myogenic conversion was accumulated since discovering this method in 1987 by R.L. Davis and H.M. Weintraub. This review is aimed to describe the fundamental bases of direct cell reprogramming, it's positioning in the system of cell fate routes, analysis of achievements in direct cell reprogramming field and discussion about unsolved issues.
The role of skeletal muscle tissue extracellular matrix components in myogenesis
Authors: Stupnikova T. V , Eremin I. I , Zorin V. L , Kopnin P. B , Gilmutdinova I. R , Saburina I. N , Pulin A. A
Published: April 2019

This review summarizes data on the structure and composition of the extracellular matrix of skeletal muscle tissue. The functions of its main components and their influence on the differentiation of cells in the myogenic direction are considered.
Evaluation of the effect of tissue-engineered constructs based on octacalcium phosphate and gingival stromal cells on dental implants osteointegration
Authors: Bozo I. Y , Deev R. V , Volkov A. V , Eremin I. I , Korsakov I. N , Yasinovsky M. I , Ustinov K. D , Trofimov V. O , Ruzin IA. , Presnyakov E. V , Komlev V. S , Pulin A. A
Published: April 2019

Current treatment of patients with partial and complete teeth loss is based on the use of dental implants. As a result of continuous improvement of the medical devices and methods of implantological treatment and according to modern protocols dental implants could be placed immediately after teeth removal, which in most cases required single-stage bone grafting. The aim of this study was to evaluate the features of dental implants osseointegration under simultaneous bone grafting with tissue-engineered construction based on octacalcium phosphate (OCP) and autogenous gingival multipotent mesenchymal stromal cells (MMSC) in rabbits. In the tibial tuberosity of each limb, we performed a complex defect consisting of two adjacent cylindrical defects with diameters of 2.8 and 4 mm, correspondingly, and a depth of 8 mm, the circumferences of which intersected at the level of 5-7 hours of the conditional dial of the upper defect. Dental implants of 3x8 mm were placed in the upper defect, the lower defect was filled with "OCP+MMSC” in direct contact with the exposed surface of the dental implant. We used OCP without cells, autogenous bone tissue, blood clot as controls. Results were assessed 1, 2, 3 months after surgery using CT and histological analysis. Osteointegration was observed in both groups with OCP, while in the case of "OCP+ MMSC” a larger volume of newly formed bone tissue was formed. Autogenous bone fragments showed results similar to a defect filled with a blood clot. Thus, the preclinical evidence makes possible to use tissue-engineering constructs "OCP+MMSC” for single-stage with dental implants placement bone grafting.
Survival and functional activity examination of cardiomyocytes differentiated from human iPSCs, when transplanting in SCID mice
Authors: Pavlova S. V , Chepeleva E. V , Dementyeva E. V , Grigor'eva E. V , Sorokoumov E. D , Slotvitsky M. M , Ponomarenko A. V , Dokuchaeva A. A , Malakhova A. A , Sergeevichev D. S , Pokushalov E. A , Zakian S. M
Published: April 2019

Conduction and heart rhythm disorders can be caused by both functional pathology and severe organic lesions of the heart. The possibility of using cell-based replacement cell therapy derived from induced pluripotent stem cells to compensate for lost myocardial tissue or the conduction system is currently being studied. The aim of the work is to study the survival and functional activity of cardiomyocytes differentiated from induced human pluripotent stem cells in intramyocardial and subcutaneous abdominal transplantation in a clots of proteins of the basement membrane matrix Matrigel to the SCID mice. After 2 and 5 weeks after intramyocardial and 2, 7, 14, 21 and 28 days after subcutaneous transplantation, the survival and activity of cardiomyocytes were studied by cytological methods. Human cardiomyocytes were detected in mice for at least 35 days. after transplantation and did not cause ectopic electrical activity of the myocardium. When assessing the functional activity of cardiomyocytes in subcutaneous matrigel plugs using the method of optical mapping of calcium ion currents for 2-28 days. after injection, it was shown that only a small fraction of cardiomyocytes after transplantation was able to spontaneously oscillate the calcium ions. We assume that contractile cardiomyocytes obtained from induced pluripotent human cells lose their ability to spontaneous excitation during in vivo transplantation, and we observe only the activity of pacemaker cardiomyocytes in optical mapping.
Unilateral condylar hyperactivity: histogenetic and patomorphological aspects
Authors: Sviridov E. G , Redko N. A , Izotov O. I , Anisimova S. A , Deev R. V , Drobyshev A. Yu
Published: April 2019

Maxillofacial deformations and malocclusions are common pathology that leads to severe functional and aesthetic disturbance. Etiological factors are trauma, genetic disorders, and hormonal imbalance. One of the rare and underexplored forms of congenital growth disorders are hemimandibular growth abnormalities as unilateral condylar hyperactivity, hemifacial elongation, condylar hypoplasia. Unilateral condylar hyperactivity (UCH) is a self-limiting pathology of mandibular condylar bone tissue overgrowth, leading to functional and aesthetic maxillofacial disturbance. The aim of the study was to identify the pathological features of hemimandibular growth abnormalities. We performed diagnostics and treatment of 35 patients (7 male, 28 female) aged from 16 to 37 years with condylar hyper- and hypoplasia. In case of unilateral condylar hyperplasia symptoms we performed high partial condyleectomy as the first step of treatment. In all the patients temporo-mandibular joint function was restored and facial aesthetic was improved as a result of treatment. According to histological features we found the materials from all patients to be divided into two groups: without pronounced continued growth and with signs of enchondral osteohistogenesis. Histological features of the pathological process were detailed in each group.
Personalized cell-based therapy in ophthalmology. III. Clinical efficacy in the treatment of corneal endothelial diseases
Authors: Avetisov S. E , Kasparova E. A , Kasparov A. A , Subbot A. M , Antohin A. I , Pavliuk A. S , Fadeeva L. L , Feofanov S. A
Published: April 2019

Severe lesions of corneal endothelium usually lead to progressing corneal oedema, sharp decrease in visual acuity and as a result to the need for transplanting donor cornea that can provoke relevant sequelae, thus an active search for alternative impacts to the affected cell layer is underway allowing for keeping out of operative intervention. The purpose of this research is to evaluate the clinical efficacy of a method of personalized cell therapy (aqueous chamber administration of suspension consists of activated autologous leukocytes in serum) aimed to treatment of early postoperative bullous keratopathy and severe form of herpetic keratoiridocyclitis. The results of clinical application of personalized cell therapy in 210 patients with postoperative bullous keratopathy (60) and herpetic keratoiridocyclitis (150) - divided into 2 subgroups: 75 patients received personalized cell therapy (experimental subgroup), the other 75 patients were injected intracamerally with a solution of poludan preparation (control subgroup), are presented in the article. The pronounced therapeutic effect in the treatment of early postoperative bullous keratopathy was achieved in 44 % of cases, with an increase in visual acuity of 0,49±0,27. Straightening of the descemet membrane's folds, significant dehydration of corneal stroma and complete restoration of corneal transparency, a reduction in the thickness of the cornea from 801±112 pm to 582±55 pm have been achieved. In the group of herpetic keratoiridocyclitis treatment, recovery was achieved in 85 % - complete resorption of corneal infiltration and edema and restoration of corneal transparency. The increase in visual acuity in this group was 0,6±0,3. The normalization of the corneal structure after personalized cell-based therapy is also evidenced by in vivo confocal microscopy data. The correlation of the clinical effect with the concentration in the cellular preparation of TNF-α, IL-6 and IL-1 was established. Personalized cell therapy is effective method of curative action on damaged corneal endothelium that does not require keratoplasty.
Tracking financial cycles in ten transitional economies 2005?2018 using singular spectrum analysis (SSA) techniques
Authors: Skare Marinko , Porada-Rochoń Małgorzata
Published: April 2019

Research background: Financial cycles are behind many deep financial crises and it closely connects them with the business cycles, showing long memory properties and effects. Being closely connected with the business cycles, we must first explore the true nature of the financial cycles to understand the nature of the business cycles. Financial cycles are real, they have long memory properties and long-lasting effects on the economy.
Purpose of the article: This study investigates the use of (SSA) in tracking and monitoring financial cycles focusing on ten (10) transitional economies 2005?2018.
Methods: Singular spectrum analysis isolate significant oscillatory patterns (cycles) on housing markets with an average 4-years length. We isolate credit cycles just for Bulgaria, implying long memory properties of the cycles since this study investigated medium term (2?5 years) oscillations.
Findings & Value added: The results prove the importance and advantages of using (SSA) in the study of financial cycles attempting to reveal the true nature of financial cycles as the principal component behind business cycles. Financial cycles show longer oscillations in the credit and property price series, which can explain 37.7%?49.9% of the variance of the total financial cycle fluctuations. Study results are of practical importance, particularly to policy-makers and practitioners in former transitional economies being vulnerable to adverse shocks on the financial markets. The results should assist policy-makers and financial practitioners in building and maintaining a sound financial policy needed to avoid future financial ?bubbles?.
Financial stability: problems of inter-level and cross-sectoral equilibrium
Authors: Gospodarchuk Galina , Suchkova Ekaterina
Published: April 2019

Research background: As part of the creation of an effective mechanism for managing financial stability, the tasks of providing an inter-level and cross-sectoral financial equilibrium remain unresolved. So far, clear and unambiguous criteria for financial stability have not been formulated, with which monetary and prudential policies could be related, as well as measures to minimize systemic and individual risks. The problem of creating a system of indicators comes to the fore, allowing the creation of new effective instruments for regulation of financial flows that contribute to the prevention of financial crises.
Purpose of the article: The paper proposes a system of indicators of financial stability, which allows for solving the tasks of inter-level and cross-sectoral equilibrium in the selection of regulatory tools for monetary and prudential policy.
Methods: We have used real interest rates as a measure of financial stability at the macro level. The real rates have been calculated from time series with nominal interest rate and inflation in the credit market (divided into loans to financial and non-financial organizations and individuals), and in the bond market (divided into corporate, municipal, and federal bonds). The analysis of the market and institutional financial stability of the USA, Russia, Japan, Switzerland, Australia over the period 1984?2014 was done. Then, comprehensive investigation on the financial stability in the Russian Federation in 2014?2017 was conducted.
The results have been compared against financial stability of individual banks, which was measured using profit to risk ratio. The latter has been calculated from bank?s financial reports using our method, which had been developed earlier.
Findings & Value added: We have developed criteria for qualitative assessment of financial stability and the risk map, which helps to identify the level of accumulated imbalances in the market and institutional environment, as well as in the levels and sectors of the economy. The criteria for selecting monetary and prudential regulatory instruments have been formulated depending on the amount of accumulated risks. The criteria for forming a portfolio of regulatory instruments with regard to their rigidity are proposed.
Differences in income distributions for men and women in the European Union countries
Authors: Landmesser Joanna
Published: April 2019

Research background: Recently there has been an increase in interest in the studies of income inequalities. The findings of numerous empirical studies show that males earn higher wages than females. A variety of techniques of income inequalities decomposition are becoming popular. New procedures go far beyond the Oaxaca-Blinder decomposition. They allow to study differences of income distributions for various groups of people and to decompose them at various quantile points.
Purpose of the article: The aim of the paper is to compare personal income distributions in selected countries of the European Union, taking into account gender differences.
Methods: First, we examined the income inequalities between men and women in each country using the Oaxaca-Blinder decomposition procedure. The unexplained part of the gender pay gap gave us information about the wage discrimination. Second, we extended the decomposition procedure to different quantile points along the whole income distribution. To describe differences between the incomes of men and women, we constructed the so-called counterfactual distribution, which is a mixture of a conditional distribution of the dependent variable (income) and a distribution of the explanatory variables (individual people?s characteristics). Then, we utilized the residual imputation approach (JMP-approach).
Findings & Value added: In the article data from EU-SILC (Statistics on Income and Living Conditions) were used. We found that there exists an important diversity in the size of the gender pay gap across members of the European Union. The results obtained for these countries allowed us to group them into clusters. In general, there are two types of countries in Europe: the countries, where the bulk of the observed income differences cannot be explained by observed characteristics, and the countries, where the explained and the unexplained effects are both positive, with even a bigger explained effect for the lower income ranges.
Mutual relationships between the unemployment rate and the unemployment duration in the Visegrad Group countries in years 2001?2017
Authors: Dmytrów Krzysztof , Bieszk-Stolorz Beata
Published: April 2019

Research background: The most important indicators that describe the situation on the labour market are the unemployment rate and the unemployment duration. If both these indicators are high, then the human capital deteriorates. Therefore, it seems justified to analyse the mutual relationships between them.
Purpose of the article: The article aims at finding the relationships between the unemployment rate and the unemployment duration, and checking if the mutual courses of these two indicators in the Visegrad Group countries are connected with each other.
Methods: The business cycle clock methodology will be used to analyse the relationship between the unemployment rate and the median unemployment duration. Next, the similarity of the course of these two indicators will be analysed by means of the Pearson product-moment correlation coefficient and the Dynamic Time Warping (DTW) technique.
Findings & Value added: Amongst the analysed countries, Czechia, Poland and Slovakia were, to a certain degree, similar with respect to the mutual course of the unemployment rate and the unemployment duration. Until the peak of the financial crisis in 2009, the unemployment rate and the unemployment duration decreased. During the next years, the unemployment rate was increasing and after 2-3 years it was followed by the increase of the unemployment duration. The situation improved after the year 2013 ? both indicators were decreasing. In Hungary, on the contrary, the unemployment rate was increasing or steady until 2012, and during the following years it started to decrease. However, the course of the unemployment duration was completely different than in remaining countries. The value added of the article is application of the business clock cycle and the Dynamic Time Warping technique in finding the relationships and similarity of courses between the unemployment rate and the unemployment duration.
The usage pattern of development method to assess the functioning of special economic zones: the case of Poland
Authors: Piersiala Luiza
Published: April 2019

Research background: In this article the characteristics of the terms of an entrepreneurship of a region and a local development were presented. Likewise, it demonstrates the results of research about using the development model method to classify special economic zones (SEZ) in terms of the most important indicators referring to the economic activity of zones in Poland, as well as showing the potential of zones ? by noting their advantage or distance in relation to another zone in terms of criteria for functioning of privileged areas forming together a group.
Purpose of the article: The aim of the article is to show the possibility to use a multidimensional comparative analysis method to recognize the level of a region?s development in a time-space system on the example of SEZ operating in Poland.
Methods: The essential data source about the article?s description were reports published by the Ministry of Economy and then the Ministry of Enterprise and Technology: Information on the implementation of the Act on Special Economic Zones. The empirical analysis used the method of multidimensional comparative analysis used to recognize the diversification of the functioning of fourteen SEZ operating in Poland in a time-space system. The examination procedure covered the years 2009?2017. A constant development pattern was adopted for all the years of the study.
Findings & Value added: The results of conducted analysis show that in SEZ there were real development processes. However, these processes were accompanied by persistent disproportions in the level of development of individual zones.
Accesso Libre
Authors: Crooks Roderic
Published: April 2019

This paper uses the concept of neoliberal responsibilization, the reductive framing of systemic power dynamics as questions of individual choice and agency, to critically interrogate equity of access to information, a central value of the broader field of library and information science (LIS). Based on a case study of Accesso Libre, a public/private partnership based in a South Los Angeles public library, I argue that equity of access to information is an insufficient concept to evaluate the power dynamics of this (and similar) partnerships, wherein powerful corporations encourage the use of commercial informational resources in minoritized communities. As an alternative, responsibilization directs analysis to different questions about equity, a set of concerns that offer LIS theorists and practitioners a way of reflecting on the ethical commitments at the core of the field. 

Pre-print first published online 03/09/2019
Zalecenia Polskiej Grupy Szpiczakowej dotyczące rozpoznawania i leczenia szpiczaka plazmocytowego oraz innych dyskrazji plazmocytowych na rok 2018/2019
Authors: Giannopoulos Krzysztof , Jamroziak Krzysztof , Usnarska-Zubkiewicz Lidia , Dytfeld Dominik , Jurczyszyn Artur , Walewski Jan , Lech-Marańda Ewa , Walter-Croneck Adam , Pieńkowska-Grela Barbara , Wróbel Tomasz , Charliński Grzegorz , Jędrzejczak Wiesław Wiktor , Małkowski Bogdan , Druzd-Sitek Agnieszka , Robak Tadeusz , Mańko Joanna , Giebel Sebastian , Czepko Ryszard , Meder Janusz , Dmoszyńska Anna
Published: April 2019

Streszczenie

Liczba chorych na szpiczaka plazmocytowego zwiększa się, co jest skutkiem zarówno skuteczniejszej diagnostyki, jak również istotnego przedłużania przeżycia chorych. Zawdzięczamy to dostępności nowych leków w pierwszej i kolejnych liniach leczenia, zmianie koncepcji leczenia i przedłużaniu czasu trwania leczenia, stosując leczenie konsolidujące oraz podtrzymujące do progresji choroby. Poza zmianą koncepcji leczenia, zmienia się obecnie również kryterium czasu rozpoczęcia terapii uwzględniające biomarkery aktywności choroby oraz dużą uwagę przywiązuje się optymalizacji leczenia w oparciu o dowody pochodzące z badań klinicznych. W artykule tym przedstawiono także zalecenia dotyczące rozpoznania i leczenia makroglobulinemii Waldenströma i innych dyskrazji plazmocytowych.
Prognostic value of soluble angiotensin II receptor 1 and soluble angiotensin converting enzyme (CD 143) in patients with acute leukemia
Authors: Ebied Samia Abd El-Moneim , Sadek Nadia Aly , Zaki Nadia El-Sayed , Kaream Samir Ali Abd El- , Kashif Heba Khafagui Ahmed El
Published: April 2019

Background

The renin-angiotensin system (RAS) is a bioenzymic cascade that plays an integral role in cardiovascular homoeostasis by influencing vascular tone, fluid and electrolyte balance and the sympathetic nervous system. RAS was viewed as a circulating endocrine system, whereby renin released from the juxtaglomerular cells of the kidney cleaves the liver-derived macroglobulin precursor angio-tensinogen, to produce the inactive decapeptide angiotensin I, which is then converted to the active octapeptide Ang II by angiotensin converting enzyme (ACE) within the pulmonary. There is increasing evidence that Ang II, a major regulator of blood pressure and cardiovascular homeostasis, is involved in the regulation of cell proliferation, angiogenesis, inflammation and tissue remodeling, which suggests that this peptide might also play a role in cancer. Ang II is the main effector of the RAS and it alternatively binds to either Ang II T1R or Ang II T2R. The Ang II T1R and Ang II T2R can act as antagonists, and mediate effects on cell migration and proliferation of metastatic cancer cells and hemopoietic stem-progenitor cells. Components of the RAS are frequently differentially expressed in various cancers in comparison with their corresponding non- malignant tissue. Yet, the RAS has not been fully elucidated in patients with acute leukemia. Objective: The aim of the present work was to study serum level of Angiotensin II receptor type 1 and the soluble angiotensin converting enzyme (CD143) in patients with acute leukemia in order to extrapolate their possible prognostic value.

Subjects and Methods

The present study included 20 healthy volunteers clinically free from hypertension or sarcoidosis, 20 patients of newly diagnosed AML and 20 patients of newly diagnosed ALL. Blood samples were collected from all subjects and the level of serum ACE and serum Ang IIT1R were measured by enzyme linked immunossorbent assay.

Results

The activity of ACE (U/L) and the concentration of Ang IIT1R (U/L) in patients groups with either AML or ALL before therapy were significantly higher than in control group. After therapy, the activity of the enzyme and its receptor concentration in both groups of patients were significantly decreased but still significantly higher than in normal control subjects.

Conclusions

Estimating the serum level of ACE and soluble Ang IIT1R is of informative diagnostic and prognostic value. Estimation serum level of ACE and Ang IIT1R levels in patients with either AML or ALL is of value in deciding the treatment protocol.
The effects of amiodarone prophylaxis on cardiac dysrhythmia in acute aluminium phosphide poisoning
Authors: Beyranvand Mohammad-Reza , Farrokhi Soleyman , Peyvandi Hassan , Soltaninejad Kambiz , Shadnia Shahin
Published: April 2019

Cardiovascular toxicity is the most common cause of fatality in the first 24 hours of poisoning with aluminium phosphide (AlP). Most often manifesting itself in cardiac dysrhythmias. The aim of this study was to evaluate the benefits of amiodarone prophylaxis against cardiac dysrhythmia in 46 patients with acute AlP poisoning. They were divided in two groups of 23: one receiving amiodarone and the other not (control). The treatment group received amiodarone prophylaxis in the initial intravenous bolus dose of 150 mg, followed by a drip of 1 mg/min for six hours and then of 0.5 mg/min for eighteen hours. Both groups were Holter-monitored for 24 hours since admission. Save for amiodarone, both groups received the same standard treatment. Amiodarone had a significant beneficial effect in reducing the frequency of ST-segment elevation and ventricular fibrillation plus atrial fibrillation (P=0.02 and P=0.01, respectively), but the groups did not differ significantly in mortality (9 vs 11 patients, respectively). The mean time between ICU admission and death (survival time) was significantly longer in the treatment group (22 vs 10 h, respectively; P=0.03). Regardless its obvious limitations, our study suggests that even though amiodarone alone did not reduce mortality, it may provide enough time for antioxidant therapy to tip the balance in favour of survival and we therefore advocate its prophylactic use within the first 24 h of AlP poisoning.
Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats
Authors: Vukšić Antonija , Lovrić Jasna , Konjevoda Paško , Blažević Nina , Bilušić Marinko , Bradamante Vlasta
Published: April 2019

The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50 mg/kg of simvastatin a day or 30 mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Simvastatin and fenofibrate caused an increase in brain BuChE activity in both normo- and hyperlipidemic rats regardless of the substrate. The increase with BTCh as substrate was significant and practically the same in normolipidemic and hyperlipidemic rats after simvastatin treatment (14–17% vs controls). Simvastatin and fenofibrate also increased liver and plasma BuChE activity in both normolipidemic and hyperlipidemic rats regardless of the substrate. In most cases the increase was significant. Considering the important role of BuChE in cholinergic transmission as well as its pharmacological function, it is necessary to continue investigations of the effects of lipid-lowering drugs on BuChE activity.
Happy 70, Archives! – our mission and vision for the years to come
Authors: Čakalo Dado , Kopjar Nevenka
Published: April 2019

This year we turn 70! Lucky for journals, they don’t get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you – our readers and authors – where we see Archives in the years to come.
Heat Treatment Effect on Lath Martensite
Authors: Fábián Enikő Réka , Kótai Áron
Published: April 2019

During our investigation lath martensite was produced in low carbon steels by austenitization at 1200 °C/20 min, and the cooling of samples in ice water. The samples were tempered at a range of temperatures. The tempering effects on microstructure and on mechanical proprieties were investigated. Some samples with lath martensite microstructure were cold rolled and heat treated at different temperatures. Recrystallization was observed after heat treatment at 600-700 °C.
Method for Emissivity Estimation of Metals
Authors: Filep Emőd , Kutasi Dénes Nimród , Kenéz Lajos
Published: April 2019

Knowledge of the surface emissivity of metals is becoming more and more important both from the material science, process modelling and control point of view. Previous research results have shown that the emissivity of most metals depends on the temperature of the surface. It has also been reported that the most important temperature region is between 300 – 1000 K degrees, where the change of the emissivity is the most intense, which is also the most significant from a process control point of view [1]. We also report temperature dependent emissivity observed during plasma nitriding of low alloy steels [2]. Related to one of our present research topics the study of the low alloy aluminum (AlMg1, AlMg3) emissivity has prooven relevant. In this article the developed emissivity estimation model is presented. In the first part a literature overview and the theoretical approach of the new method is discussed, followed by the experimental results for low alloy aluminium emissivity determination and a comparison with the results available in the literature.
Effect of Expansion Pressure on the Drug Eluting Coating and the Corrosion Characteristics of Coronary Stents
Authors: Horicsányi Krisztina , Asztalos Lilla , Károly Dóra , Fazakas Éva
Published: April 2019

During implantation, stents are delivered in crimped state to the narrowed lesion, where they are expanded to the desired size by the balloon. Due to insufficient size selection or high resistance to plaque, the stent is often widened by the expansion pressure to a level greater than the nominal pressure specified by the manufacturer. Depending on the degree of overpressure, the nominal diameter of the stent may change by several tenths of a millimetre. Numerous studies have dealt with the physiological effects of overexposure and stenogenic stress, but so far no studies have been carried out to investigate the stent coating and corrosion properties of the stent. In our research a widely used drug-eluting, platinum-chromium alloyed steel stent was observed with an inflation pressure of 12 and 18 bar. Scanning electron microscopy revealed lesions of the coating and potentiodynamic tests were performed to determine the corrosion rate.
Corrosion Testing of Additively Manufactured Metals and Biomedical Devices
Authors: Kemény Dávid Miklós , Károly Dóra
Published: April 2019

Additive manufacturing (AM) is becoming increasingly important, making it possible to produce a product in a short time, to specific individual requirements, and even in the presence of the customer. This research is related to direct metal laser sintering of additive manufacturing. This new technology is increasingly being used in more sectors, for example in biomedical industry, where a damaged product can potentially endanger human life. Corrosion tests were carried out during our research. Cyclic voltammetry curves and corrosion rates were determined with a potentiostat. Two typical biocompatible implant materials were compared, a cobalt chromium alloy (powder metallurgy) and a titanium alloy (3D printed). The results will help in specifying the corrosion properties of additively manufactured materials.
Investigation of Laser Welding Technology of Diamond Drilling Segments
Authors: Kenéz Attila Zsolt , Bagyinszki Gyula
Published: April 2019

Segments containing diamond particles are fixed to replaceable inserts or to steel tool bodies for cost-effectiveness. The joining technology used should meet both environmental and technical requirements. The joining zone is subjected to high mechanical and significant thermal loads during use. In the event of an improper joint, the segments may detach from the base and fly away causing injury. Nowadays, many methods of welding or brazing are used to fix diamond segments. Among the possible segment fixing technologies, laser beam welding has been investigated. The microstructure of the joints has been examined by optical and scanning electron microscopy and chemical element maps have been recorded. Joints have been subjected to fracture and hardness testing. The mechanical properties and composition changes of the joints with different joining technologies have been evaluated and compared.
Addictive and Substractive Combined Production of Cobalt-Crome-Based Frames in Dentistry
Authors: János Kónya , Klaudia Kulcsár
Published: April 2019

The following study analyses the use of modern 3D printing technology in dentistry with its necessary manufacturing and machining processes. Fitting of the manufactured metal structures is examined depending on their use, in terms of conventional adhesion-based denture designs and screw-fixed dentures on implants. Influencing factors and effects of the required post-processing steps are examined. Aspects such as sand-blasting, heat treatment, equipment and tools required for cutting are analyzed. The aim of this study is to create a manufacturing process that enables the required precision fitting of the created frame structure types.
Application of High Energy Absorbing Materials for Blast Protection
Authors: Kovács Tünde , Nyikes Zoltán , Figuli Lucia
Published: April 2019

In the current century, building protection is very important in the face of terrorist attacks. The old buildings in Europe are not sufficiently resilient to the loads produced by blasts. We still do not fully understand the effects of different explosives on buildings and human bodies. [1–3] Computing blast loads are different from that of traditional loads and the material selection rules for this type of impact load are diverse. Historical and old buildings cannot be protected simply by new walls and fences. New ways need to be found to improve a building’s resistance to the effects of a blast. It requires sufficiently thin yet strong retrofitted materials in order to reinforce a building’s walls [4–6].
Mechanical Studies of Injection Molded Composites with Polypropilene Matrix
Authors: Istvánné Ráthy , Péter Pinke , Csenge Huszák
Published: April 2019

The wide use of composite materials is mainly due to their excellent strength / mass ratio, corrosion resistance and relatively low price. Approximately 35-40% of the fibre-reinforced composites are made of thermoplastic polymers in which fibreglass, carbon or natural fibres are most often used as reinforcement, while the remaining 60 – 65% is made up of high-tech carbon or glass fibre-reinforced thermosetting composites. Most of them are used in the transport and electronics industries. New processing technologies not only improve the properties of the products but also contribute to reducing costs.

In this paper, we compare the results of mechanical tests with molded standard specimens with polypropylene matrix and test results from cut-outs from injection molded products.
The Effect of Administration of Copper Nanoparticles in Drinking Water on Redox Reactions in the Liver and Breast Muscle of Broiler Chickens
Authors: Ognik Katarzyna , Cholewińska Ewelina , Stępniowska Anna , Drażbo Aleksandra , Kozłowski Krzysztof , Jankowski Jan
Published: April 2019

The aim of the study was to determine what dosage of copper nanoparticles added in the form of a hydrocolloid to standard dietary supplementation with copper sulphate will increase the antioxidant potential in the liver and breast muscle of chickens. In total, 126 one-day-old Ross 308 chickens were assigned to 7 experimental groups of 18 birds each (3 replications of 6 individuals each). The basal-diet treatment did not receive nano-Cu. Experimental groups received nano-Cu (0.5, 1.0 or 1.5 mg/kg body weight per day) via a tube into the crop over three 3-day periods (days 8–10, 22–24 and 36–38) or three 7-day periods (days 8–14, 22–28 and 36–42). Dietary supplementation of chickens with nano-Cu to exceed the Cu level recommended by the NRC increased the content of Cu (P=0.042) while reducing that of Zn in the liver (P=0.031) and breast muscle (P=0.036). Supplementing the diet of chickens with nano-Cu to a level exceeding the level of copper recommended by the NRC by 7% to 25% increased the antioxidant potential of the liver and the breast meat. The study has shown that the antioxidant status of the liver and breast meat of chickens can be improved by supplementing the standard dietary copper sulphate supplement with the addition of nano-Cu, but to a level not exceeding 25% of the copper content recommended by NRC (1994) for broiler chickens, but the most safe is the nano-Cu level not exceeding 7% of the copper content recommended by NRC (1994).