bluuebunny/crossref_metadata_2025 huggingface dataset:
Teachers' metaphors about "creative thinking"
Authors: Özgen Vildan , ERDEM Ali Rıza
Published: July 2023

The aim of this study is the 21st century, which has an important place in the cognitive, emotional, academic and social development of students. The aim is to reveal the metaphors produced by teachers, who are in the position of gaining creative thinking, one of the learning and innovation skills, about creative thinking. The research was carried out with 10 teachers working in different types and levels of public schools in the Efeler district of Aydın province in the 2022-2023 academic year. In the study, in which the phenomenological approach, one of the qualitative research designs, was used, the participants were asked a question in the semi-structured "creative thinking metaphor interview form" prepared by the researchers and the data obtained were analyzed by content analysis. The metaphors produced by the teachers in the study group about creative thinking were grouped into four categories: "generating original ideas", "problem solving", "rethinking" and "creating an original product".
Stigmas Of Lgbt+Q Families In Today's Society
Authors: Dra. Yoya Betzabe Flores Pérez  , Ms. Franklin Elder Abanto Chávez  , Ms. Rigoberto Hernán Navarrete Flores  , Ms. Luz HerfiliaCruzado Saucedo  , Ms. Fany Margarita Aguilar Pichón
Published: July 2023

The present research aimed to identify the stigmas of discrimination and social exclusion caused by prejudice and homophobia against LGBT+Q families in the district of Trujillo. A descriptive correlational study was carried out with a sample of 150 people from the district of Trujillo with a medium-high socio-economic level, aged between 18 and 54, who were questioned to find out about the stereotypes that exist in Trujillo society, and the information was processed and analyzed in tables and figures. The stigmas against people who identify with the LGBT+Q community within their own family are directly related to the traditional way of thinking of people and the rigid way of being within Trujillo society, which, added to the experience of those who suffer from stereotypes, indicates that there
Psychological Resilience In The Religious Life: Conceptual Framework And Efforts To Develop It
Authors: Yoseph Pedhu
Published: July 2023

Resilience is an individual's effort to withstand and grow healthily in facing a stressful life. Resilience is very useful, especially in helping individuals develop a better life which consists of components of emotional regulation, impulse control, optimism, empathy, the ability to analyze problems, self-efficacy, and increasing positive aspects. Religious life is a form of a life dedicated to God and freely chosen by individuals that are manifested in the fulfillment of religious vows. This article aims to examine resilience in the religious’ life and constructive ways to develop it. The author examines the meanings, dimensions, supporting factors, and previous studies that contribute to resilience. Based on previous concepts and research, the author outlines several ways that can be applied in helping a religious develop resilience in his/her life.
Sistem Pendukung Keputusan Kemampuan Toefl Wisudawan Sistem Informasi Stmik Indonesia Padang
Authors: Sari Mega , Purwasih Ratih , Putri Yessy Prima
Published: July 2023

Sistem pendukung keputusan merupakan sebuah sistem yang dapat membantu memudahkan pekerjaan pengguna dalam mengambil keputusan secara tepat. Berdasarkan data penilaian dari dosen bahasa Inggris STMIK Indonesia Padang bahwa mekanisme pengambilan keputusan penilaian TOEFL wisudawan sistem informasi STMIK Indonesia Padang membutuhkan waktu yang lama. Karena jumlah peserta yang cukup banyak sehingga membuat pihak dosen dan tim penilai mengalami kesulitan dalam memproses data peserta, maka diperlukannya sebuah sistem pendukung keputusan  penilaian kemampuan berbicara bahasa Inggris pada STMIK tersebut. Sistem pendukung keputusan terdapat berbagai metode salah satunya metode weight product (wp). Metode weight product (wp) merupakan sebuah metode pengevaluasian beberapa alternatif terhadap sekumpulan atribut atau kriteria. Sistem pendukung  keputusan penilaian kemampuan berbicara bahasa Inggris mahasiswa STMIK Indonesia Padang  menggunakan metode weight product (wp) dirancang dengan menggunakan bahasa pemograman PHP dan MySql sebagai basis datanya. Hasil dari penelitian ini diharapkam sistem pendukung keputusan dengan menggunakan metode WP berbasis website yang dapat membantu meringankan pekerjaan dosen dan tim penilai dalam memberikan penilaian secara mudah, tepat dan jelas dengan keaadaan yang tidak ambigu.
Los microplásticos en el entorno acuático: Un vistazo a la cinética, mecanismo de degradación, impacto ambiental y en la salud humana
Authors: Cuadra Víctor , Lezcano Ritzela , Bayard Carmelo , Villarreal José , Robinson-Duggon José , Miranda-Montenegro Mario Luis
Published: July 2023

Desde su origen en la década de los años 50’s, los plásticos se han convertido en un material omnipresente en la vida diaria de nuestras sociedades. A pesar de su amplia gama de usos, la lenta degradación de estos materiales en el ambiente ha ocasionado un problema de contaminación emergente de consecuencias aún desconocidas. El objetivo de esta revisión es el de evaluar el impacto que ha tenido la introducción de los microplásticos en nuestros ecosistemas. Reportes recientes indican que la presencia de microplásticos se ha extendido hasta ambientes prístinos como los polos del planeta. La degradación de los materiales plásticos, en partículas de menor tamaño llamados microplásticos cuando su diámetro es menor a 5 mm y su ingesta por organismos diversos plantea la pregunta de cuál es el efecto a largo plazo en la salud de los ecosistemas. Efectos adversos en el metabolismo de microorganismos, peces y en el ser humano han sido ampliamente documentados. Igualmente, se ha reportado la capacidad de estas partículas de movilizar contaminantes ambientales como metales pesados, hidrocarburos, e incluso virus. Entre estos efectos adversos se incluyen alteraciones metabólicas, formación de especies reactivas de oxígeno y modificación de procesos inflamatorios. Podemos concluir que la presencia de las partículas de microplásticos están presentes en diversos nichos de los ecosistemas terrestres y que su degradación introduce compuestos químicos potencialmente disruptivos en ellos. Por lo que entender el origen, transformación, rol en el transporte y liberación de contaminantes en el ambiente nos permitirá diseñar estrategias para minimizarlos.
RADIOGRAPHY TECHNIQUE OF OS FEMUR DEXTRA IN CASE OF 1/3 DISTAL FRACTURE AT RADIOLOGY INSTALLATION OF EFARINA ETAHAM BERASTAGI HOSPITAL IN 2021
Authors: Sihat Manisia Siboro  , Saufa Taslima  , Juni Sinarinta Purba  , Awan Pelawi  , Bambang Kustoyo  , Dea Rahmayani Barus
Published: July 2023

A fracture is a break in the continuity of the epiphyseal plate or growth cartilage (Foris and Waseem, 2018). A fracture is a loss of bone continuity, either totally or partially, caused by trauma or physical exertion. This research was conducted to determine the characteristics of patients with femoral fractures due to traffic accidents at Efarina Etaham Berastagi Hospital in 2021. This study used a descriptive method. research is the entire population that follows the inclusion and exclusion criteria. The sample selection was carried out by the total sampling method. This research was conducted by looking at secondary data, namely medical records of patients with femoral fractures due to traffic accidents at Efarina Etaham Berastagi Hospital.
RADIOGRAPHY TECHNIQUE OF OSSA MANUS WITH SUSPECTED FRACTURE OF PROXIMAL PHALANG DIGITI 4 AND 5 SINISTRA IN RADIOLOGY INSTALLATION OF EFARINA HOSPITAL Pangkalan KERINCI, 2020
Authors: Bambang Kustoyo  , Veryyon Harahap  , Awan Pelawi  , Sabrina Suci Zasneda  , Sihat Manisia Siboro  , Dea Rahmayani Barus
Published: July 2023

Radiographs of the human bones are the bones consisting of the carpal bones, the metacarpal bones and the phalanges. Fractures are broken bones, usually caused by trauma or physical exertion, the force and angle of the force, the condition of the bone itself, and the soft tissue around the bone will determine whether the fracture is complete or incomplete. A complete fracture occurs when the entire bone is broken, whereas an incomplete fracture does not involve the entire thickness of the bone. The occurrence of fractures caused by traffic accidents. The purpose of this study was to determine the procedures for carrying out radiography of the human oss with suspected fracture at Efarina Pangkalan Kerinci Hospital. The type of research used was descriptive with data collection techniques by means of observation, documentation and interviews. The results of the examination of the human oss in fracture cases at Efarina Pangkala Kerinci Hospital are generally using postero-anterior and oblique projections. The ideal x-ray machine for ossa manus radiography is a portable x-ray unit or a mobile x-ray unit with relatively low capabilities. The x-ray film used is a high speed type combined with a fast screen intensifying (IS) where this type of film and intensifying screen (IS) can produce images with good detail and sharpness. Thus the radiation dose can also be reduced for the patient and the operator himself. The x-ray film washing process used should preferably use automatic processing. It is hoped that it can be used as a reference for radiographic results, especially in fracture cases.
Spillover Effect of Chinese Export on New ASEAN-5 Stock Markets using Markov Regime Switching Model
Authors: Fu Maggie Mei-Zhi , Tan Kokkiang , Rose Ahmad Nadzri , Samadi Banafsheh
Published: July 2023

China as the second largest economy supposes to produce spillover effect on the emerging market economies especially the ASEAN nations. The main objective of this paper is to study the spillover effect of the Chinese export on the new ASEAN-5 stock markets (Indonesia, Malaysia, Philippines, Thailand, and Vietnam). In this paper, multivariate Markov-Switching Intercept Autoregressive Heteroscedasticity (MSIAH) model is employed to analyze the linkage between Chinese export and the new ASEAN-5 stock markets over the sample period of August 2000 to December 2018. The monthly data have been analysed using EViews. Their relationship is also strong and positive. The findings report that the spillover effects of China export on new ASEAN-5 stock markets is significant. There is positive relationship between China export and the stock markets for both regimes. The conclusion can be made is China exports should be one of the important factors in determining the stock prices in new ASEAN-5 stock markets. Investors should alert China export information when investing in new ASEAN-5 stock market. New ASEAN-5 are important emerging economies in Asia Pacific region and China is a rising economic power, but there is very least literature to study the Spillover effect of China export on stock market in new ASEAN-5.
Pelatihan dan Pendampingan Pembuatan QRIS pada Sentra Industri di Alat Dapur di Kota Semarang
Authors: Mege Stacia , Suwandi Suwandi , Kurniawati Nurul Imani
Published: July 2023

Rapid technological developments produce various kinds of innovations that aim to facilitate all human activities, including business activities. Business actors are provided with various kinds of conveniences through these technological advances, such as selling online so they don't build physical stores, expanding the target market by selling overseas, business bookkeeping that is made easier with various applications, to payment methods that are increasingly leading to cashless, and with QRIS, buyers can make payment transactions through mobile banking applications from various banks, electronic money, or electronic wallets which are increasingly prevalent in Indonesia. The obstacle faced was when the technology could not be utilized by most business actors. To overcome this problem, the service team conducted training for the kitchen appliance industry center in Semarang. The method chosen to overcome the problems that exist with partners is first the socialization of providing material to provide a detailed explanation of the topic. The second method is by training. This training method is very suitable for MSMEs so that they can directly practice the material that has been studied before. The results of this activity indicate that there is a need to modernize payment methods at all industry levels including at the small and medium business level, the use of QRIS will make sellers more helpful in terms of transactions.
Nuevas tesis sobre los valores estéticos
Authors: Fabelo Corzo José Ramón
Published: July 2023

Las tesis que aquí se presentan han sido elaboradas a partir del análisis del ensayo de Jan Mukarovsky: “Función, norma y valor estético como hechos sociales”. (Cfr. Jan Mukarovsky. Escritos de estética y semiótica del arte, pp. 44-121). Las mismas han sido enriquecidas como resultado del debate que, generación tras generación, sobre ellas hemos sostenido con los estudiantes —la mayoría de ellos hoy egresados del posgrado en Estética y Arte de la BUAP—. Es un trabajo que lleva su huella y ningún marco mejor para incluirlo que el de este libro de la serie Academia y Egresados de la Colección La Fuente. Sirva su publicación, entonces, como reconocimiento a la participación activa y creativa de todos ellos en esos siempre gratificantes cursos de Estética y Teoría del Arte III.
La communication comme levier du dénouement de la crise pré- électorale de 2016 en République Démocratique du Congo
Authors:   Université de Kinshasa, MPUTU Jenny
Published: July 2023

Alors que les observateurs craignaient que le combat communicationnel entre le régime Kabila et les opposants face à l’impératif de l’alternance démocratique à la tête du pays en 2016 génère un Etat de siège, un coup d’Etat ou une guerre civile, celle-ci a eu pour résultat, une accalmie générale assortie de trois vertus principales à la démocratie, à savoir, la dynamique relationnelle parce qu’en crise, on ne peut plus se satisfaire d’une réponse linéaire ou mécanique, mais plutôt relationnelle. C’est l’ère de la confrontation d’opinions, de points de vue, des attentes et cela en vue de parvenir à un compromis ; la logique négoïste qui fait obligation de congruence, mieux, obligation d’accord aux acteurs politiques et négociateurs dans lequel chaque partie doit gagner quelque chose sur ses revendications et la communication est devenue l’axe principal et privilégié dont les opérateurs politiques doivent toujours en tenir compte, car désormais, c’est l’esprit qui triomphe sur le sabre. Mots-clés : Crise, Elections, Systémique qualitative, Négociation.
Problématique de la sécurité physique et logique des ordinateurs dans un établissement public. Cas de l’assemblée provinciale du Maniema de 2020 à 2021
Authors:   ISIGE/Kindu, RAMAZANI KATCHIMBWA Jean de Dieu , OTCHUDI Faustin Jonas
Published: July 2023

La valeur de notre civilisation se déplace inéluctablement vers la sphère immatérielle. La miniaturisation continue de l’électronique, l’accélération des performances des réseaux de communication et le déploiement inexorable des infrastructures informatiques édifient une urbanisation digitale qui favorise l’accès à l’information et facilite la communication. Sur une population de 119 personnels de l’Assemblée Provinciale de Maniema, nous avons prélevé un échantillon de 33 enquêtés, composés principalement des utilisateurs des dispositifs informatiques dont les opérateurs de la saisie de chaque cabinet politique, de l’administration et des utilisateurs des ordinateurs dans tous les bureaux de cette institution politique de la province du Maniema au cours de l’installation en mars 2019 du bureau définitif de cet organe. Les résultats nous montrent que 91% des utilisateurs des dispositifs informatiques n’ont pas des notions de base sur la sécurité de ces dispositifs informatiques ; tous les utilisateurs de ces dispositifs ne mettent jamais à jour leurs antivirus. 80% de ces utilisateurs ne scannent ou n’analysent pas tout support provenant de l’extérieur, alors que 20% seulement le font. 80% ne font pas la partition du disque dur pour savoir loger et protéger les éléments importants ; 92% n’ont pas un stabilisateur et/ou un ondulaire en marche connectés au courant électrique et enfin, 100% de ces utilisateurs ne couvrent pas les ordinateurs avec une étoffe après usage pour éviter des poussières. Il s’avère nécessaire de former les utilisateurs de dispositifs informatiques à l’Assemblée Provinciale sur les notions de cybersécurité. Mots-clés : Virus, antivirus, ordinateur, informatique, utilisateur
Makna Al-Qurán Secara Umum dan Kedudukannya sebagai Sumber Ilmu Pengetahuan
Authors: Hidayatulloh M. Deni
Published: July 2023

This paper discusses the meaning of the Qur'an, both in terms of language and terminology. Many scholars have different views on its definition. It also discusses the position of the Qur'an as a science. This paper is a library research, by collecting related literature, then presented in a descriptive qualitative manner, namely presenting the data as it is. Based on the words of Allah SWT accompanied by asbabu nuzulnya about the verse. The Qur'an was revealed as a guide to realize the mission of Islam, which is rahmatan lil aalamin. In this case, it is the duty of humans to observe, examine, search and explore the values contained in the Qur'an. There are many verses of the Qur'an that give hints about science and even technology, however, this position is still not widely realized by Muslims themselves. If these signs can be uncovered, then it can be a strengthening of the faith of Muslims and even become an effective means of broadcasting Islam. However, this position is still not widely realized by Muslims themselves. If these signs can be uncovered, they can strengthen the faith of Muslims and even become an effective means of propagating Islam.
FAKTOR YANG BERHUBUNGAN DENGAN TINGGINYA PENGGUNAAN KB HORMONAL SUNTIK PADA PUS USIA DI ATAS 40 TAHUN DI PMB “NMS”
Authors: Ni Made Sumberhati  , Kadek Ayu Suarmini
Published: July 2023

Kontrasepsi merupakan salah satu upaya untuk mencegah terjadinya kehamilan. Upaya itu dapat bersifat sementara, dapat pula bersifat permanen. Pada saat ini telah banyak beredar berbagai macam alat kontrasepsi. Macam-macam metode kontrasepsi tersebut adalah Intra Uterine Device (IUD), implant, kondom, suntik, metode operatif untuk wanita (MOW), metode operatif untuk pria (MOP), dan kontrasepsi pil. Alat kontrasepsi hendaknya memenuhi syarat yaitu aman pemakaiannya dan dapat dipercaya, efek samping yang merugikan tidak ada, lama kerjanya dapat diatur keinginan, tidak mengganggu hubungan seksual, harganya murah dan dapat diterima oleh pasangan suami istri.  Penelitian ini menggunakan pendekatan kualitatif. Jenis penelitian ini adalah penelitian survei analitik. Disebut penelitian survey analitik karena peneliti mencoba mencari hubungan antarvariabel. Pada penelitian ini dilakukan analisis terhadap data yang dikumpulkan, karena itu pada penelitian perlu dibuat hipotesis. Desain atau rancangan penelitian yang digunakan dalam penelitian ini adalah cross sectional. Dari hasil penelitian didapatkan adanya hubungan antara pengetahuan dan jarak kelahiran terhadap tingginyya penggunaan kontrasepsi hormonal suntik. Sedangkan tidak ada pengaruh atau hubungan pada paritas dengan pingginya penggunaan kontrasepsi hormonal suntik.
Identifikasi Drug Related Problems Potensial Kategori Interaksi Obat Pada Pasien Hipertensi Geriatrik di Instalasi Rawat Inap Rumah Sakit XYZ Tangerang
Authors: Saputro Muhamad Fajar , Putra Ari Permana , Aisyah Rizka
Published: July 2023

Hipertensi merupakan penyakit yang berhubungan dengan tekanan darah manusia. Diagnosis dari hipertensi dapat di tegakkan jika rata-rata hasil pemeriksaan darah pada diastolik ≥90 mmHg dan sistolik ≥120 mmHg. Penurunan elastisitas pembuluh darah serta penyempitan pembuluh darah arteri pada lansia merupakan salah satu faktor resiko terjadinya hipertensi.

Tujuan dalam penelitian ini adalah untuk mengidentifikasi DRPs kategoro interaksi obat meliputi interkasi obat potensial, interaksi obat berdasarkan mekanisme, dan interaksi berdasarkan level signifikansinya pada pasien hipertensi geriatrik di instalasi rawat inap Rumah Sakit XYZ Tangerang.

Penelitian ini merupakan penelitian non-eksperimental deskriptif analitik dengan pengumpulan data secara retrospektif menggunakan data berdasarkan catatan medis di Rumah Sakit XYZ Tangerang, pengambilan sampel menggukan metode purposive sampling.

Berdasarakan hasil penelitian yang dilakukan di Rumah Sakit XYZ Tangerang bahwa;  Interaksi obat potensial terjadi pada 20 (48,78%) pasien dengan jumlah kasus interaksi sebanyak 61 kasus; interaksi yang terjadi pada fase farmakokinetika sebanyak 20 kasus (32,79%) dan interaksi yang tidak diketahui mekanismenya sebanyak 19 kasus (31,15%); berdasarkan level signifikansinya terjadi 10 kasus (16,39%) interaksi yang mempunyai level signifikansi I, level signifikansi II berjumlah 10 kasus (16,39%), level signifikansi III sejumlah 4 kasus (6,56%), level signifikansi IV sejumlah 18 kasus (29,51%), level signifikansi V sejumlah 14 kasus (22,95%) dan interaksi yang belum diketahui level signifikansinya sejumlah 5 kasus (8,20%).
A Model Experiment Design Using the Taguchi Method: A Case Study Of Making Concrete Roof
Authors: Nur Permadi Idris , Basiratun Nisa Dini
Published: July 2023

This research was conducted at a company manufacturing paving blocks, ceramics, ventilation, concrete, and roof tiles. This study aims to improve the quality of concrete tile products, which experience the most cracks and breaks. Research to determine the composition of concrete roof tiles can be carried out by design experiments using the Taguchi method. This experiment used raw materials such as cement, sand, milled flour, and water. The concluding results show that the quality of concrete roof tiles is based on the results of the Taguchi method and confirmation experiments which are characterized by an increase in the compressive strength of the concrete tile based on the average value (μ) and its variability (SNR). The average compressive strength (µ) of concrete roof tiles increased from 19,814 ≤ 21,208 ≤ 22,602 in the Taguchi experiment to 26,406 ≤ µconfirmation ≤ 29,894 in the confirmation experiment. While the variability (SNR) increased from 25.532 ≤ 27.521 ≤ 29.510 in the Taguchi experiment to 26.473 ≤ S/N confirmed ≤ 31.469 in the confirmation experiment. The optimal composition of cement, sand, milled flour, and water that produces the best compressive strength based on the response factor and SNR is 0.9 kg: 0.5 kg: 0.4 kg: 0.3 kg, respectively. The most influential factors on the compressive strength of concrete roof tiles are the amount of sand and the number of flour mills.
Design of Smart Locker Door Using Quality Function Deployment Based on ATMega 2560 Microcontroller
Authors: Filhaq Gozy , Aprianto Sudrajat , Alfianto Harly
Published: July 2023

Smart Locker system to provide more security for the house that is a place to live to avoid losses and negative impacts of criminal case actions with incrimination.  This study designed door security with a door bar control system that can be done from outside the house using Android and a keypad so that the bar behind the door automatically closes and opens according to the password code command entered by the user or homeowner. Consumer desires home security systems using the QFD (Quality Function Deployment) method. The QFD method will conclude that a better door security product design is needed, with home security system updates as needed. Consumers need thirteen dimensions with three priorities with the highest value, namely securing the door of the house with a shape that matches the door with a rating of 4.55, Securing the door of the house has an alarm system with a rating of 4.50, Securing the door of the house is easy to use for the owner.  The intelligent locker design is based on ATMega 2560 Microcontroller, which functions to program other components so that they can work according to the data that has been inputted
Attorneys-at-Law in the Courts of Samogitia in the Early Seventeenth Century
Authors: Vilimas Darius
Published: July 2023

Based on surviving court books, the article examines the work of early pre-lawyers, known as attorneys-at-law, in the courts of Samogitia in the first decade of the seventeenth century. A preliminary list of such attorneys was compiled and is included in the article, the nature of the disputes they represented in court is discussed, some of the most active attorneys are identified, and their origins are discussed.
Food Products and Dishes on the Table of Władysław IV Vasa, King of Poland and Grand Duke of Lithuania
Authors: Dambrauskaitė-Martinkėnė Neringa
Published: July 2023

Based on the data of the kitchen accounts of 1632–1633 and other relevant sources, the article aims to shed light on the assortment of the food products and beverages supplied to the kitchen of Władysław IV Vasa, King of Poland and Grand Duke of Lithuania, and the dishes that used to be cooked for the ruler. The analysis shows that beef, mutton, piglets, meat of domestic birds, wild animals (hares, deer), and wild birds (most often black grouse, hazel grouse, partridges, thrushes, pigeons) were delivered to the court kitchen of the ruler. Interestingly, turkeys were supplied to the kitchen of Władysław IV Vasa very often, not only during feasts. During fasts, different types of fish were consumed, but the salmon was purchased only on special occasions. The analysis also reveals the assortment of dairy products, bread, cereals, sweets, local vegetables, local and imported fruit, spices, and beverages. The sources even reveal ingredients of some dishes and pastries cooked for the ruler’s table: meat jelly, pâté, stews of various meats and vegetables (olla pulreda), rice pudding (bianka), Easter cake, and others.The cuisine of Władysław IV Vasa shared some features with Western European Renaissance cuisine: it followed the fashion of eating wild birds and sweets and consuming imported spices. The influence of French cuisine was more pronounced, although the French elite began to abandon the abundant consumption of imported spices during that period.
Egenmäktigt förfarande
Authors: Sager John-Henry , Thomasson E
Published: July 2023

Intet resumé
Forskning, kriminalpolitik och verkligheten
Authors: Kühlhorn Eckart
Published: July 2023

Intet resumé
Er udlændinge kriminelle?
Authors: Schwarz Finn , Juhler Hans
Published: July 2023

Intet resumé
Narkotikakontroll i Finland
Authors: Hakonen Kimmo , Kontula Osmo
Published: July 2023

Intet resumé
Forbryder vs. offer
Authors: Grothe Nielsen Beth
Published: July 2023

Taking its point of departure in Vagn Greve's contention (1972) that everybody is a criminal but only a certain group of people are punished and Greve's proposal that the explanation may be found in the relationship between offender and victim, this article looks into that relationship.
The labelling of offenders as well as victims will take place according to certain stereotypes. But there cannot always be found a clear line of distinction between the two. Offenders and victims are interchangeable
(Fattah, 1994). Danish criminal court cases of violence which illustrate that fact are put into a theoretical context (Katz, 1988; Polk, 1994).
A different type of merging of the two concepts is the victim who becomes an offender - sometimes when he or she is also still a victim.
While criminology has always had difficulties in integrating into its theories the knowledge that offenders experience victimization, victimology - especially recent variants - has a tendency to ignore the fact that victims are not only "white" and offenders not only "black". "The ideal victim" {Christie, 1986) seems to encompass many more types than the little old lady on her way home from her sick sister in the middle of the day. Victims are idealised and a false dichotomization between offender and victim has (re)emerged. "The victims' case" is used politically as an excuse for "getting tough on crime" in Denmark as elsewhere. The answer to the headline question is: Yes, often.
Corpus juris.
Authors: Jareborg Nils
Published: July 2023

Corpus juris is the outcome of a European Community project, organized by Franceso de Angelis, Director of General Directorate XX (Financial Control). The text, which comprises 35 articles on criminal law and criminal procedure concerning protection of the financial interests of the European Union, was in the final version drafted by Professor Mireille Delmas-Marty (Paris). The most striking feature of the proposal is the establishment of a European Public Prosecutor for crimes of the kind indicated. The article contains a translation of the 35 articles into Swedish and a brief introduction explaining the background, underlining the fact that the proposal is a hurried piece of work.
La estrategia de la Unión Europea frente al cambio climático
Authors: Padilla Rosa Emilio
Published: July 2023

Las características del cambio climático hacen que se requiera de una actuación coordinada a nivel global para conseguir una mitigación efectiva del mismo. Se presenta la evolución de la contribución de la Unión Europea al problema, así como sus esfuerzos de reducción de emisiones, en el contexto internacional. La decreciente importancia relativa de la Unión Europea en las emisiones globales hace evidente la necesidad coordinar internacionalmente sus políticas. Se presentan los objetivos y la estrategia de política climática de la Unión Europea, actualizada con el paquete “Fit for 55”, que suponen un salto de ambición en las metas y medidas, así como un avance positivo en varios aspectos de la política climática. Finalmente, se incide en la necesidad de avanzar en las políticas de poner precio al carbono —tanto por sus ventajas como instrumento como por su mayor facilidad para coordinar políticas más ambiciosas a nivel internacional - y se recogen algunas propuestas en este sentido.
Política fiscal para un nuevo régimen de bienestar post pandemia COVID-19 basado en Buen Vivir
Authors: García Álvarez Santiago
Published: July 2023

Los grandes impactos provenientes de la pandemia sanitaria del COVID- 19 mostraron los límites economicistas e instrumentalistas de la política fiscal, que fue desbordada por la crisis disruptiva en todos los países del mundo; además, se presentan grandes retos para enfrentar el cambio climático. En tal contexto, este trabajo tiene como principal objetivo analizar y proponer un conjunto de principios e instrumentos que deberían caracterizar a la política fiscal para alcanzar un nuevo régimen de bienestar denominado Buen Vivir, que a su vez comprende tres elementos fundamentales: i) sostenibilidad biocéntrica, ii) equidad social y, iii) satisfacción personal. La metodología utilizada es básicamente de revisión bibliográfica bajo la técnica de referencias cruzadas, sobre los conceptos de régimen de bienestar y Buen Vivir. Se pasa revista a los principales planteamientos fiscales provenientes tanto del nuevo consenso macroeconómico, así como de la llamada macroeconomía para el desarrollo y la política fiscal contra-cíclica de la CEPAL. Se concluye que la política fiscal para el Buen Vivir cambia la visión fiscal instrumentalista y la relaciona con una visión amplia e integrada en los ámbitos sociales, económicos y ambientales, pero sin dejar de lado los criterios de sostenibilidad de los procesos a través de generación de ingresos y financiamiento adecuados, por tanto, tendría un nivel superior a los planteamientos del mainstream y del neoestructuralismo latinoamericano
Influencia de la incertidumbre de política económica en las cotizaciones de la Bolsa de Valores de Panamá
Authors: Sánchez Gabarre Mary Elena , Castellanos García Pablo , Herrera Ballesteros Víctor Hugo
Published: July 2023

El objetivo principal de este trabajo es estudiar la relación existente entre el índice bursátil de referencia en Panamá y la incertidumbre de política económica desde una perspectiva tanto a nivel global como a nivel nacional. En particular, se pretende profundizar de forma novedosa en el análisis de esta relación para saber hasta qué punto los hechos de política económica afectan a los movimientos bursátiles panameños, adoptando como hipótesis de partida que un incremento en la incertidumbre está asociado a una disminución de los índices bursátiles; es decir, que la relación incertidumbre-cotización sea inversa. Para ello, se tienen en cuenta los datos comprendidos en el periodo de enero de 1997 a diciembre de 2020 con una periodicidad mensual. Este estudio se lleva a cabo a través de la descomposición de las series temporales, así como de la aplicación de la metodología GARCH, pues es el que nos permite suplir la información producida por las variaciones en los precios. Los resultados obtenidos nos llevan a concluir que la influencia de la incertidumbre de política económica, afecta de forma negativa en las cotizaciones bursátiles del índice de referencia de Panamá.
El sector del vino en España. Una aproximación desde la perspectiva de la política económica
Authors: Juste Carrión Juan José , Peñas Moyano Benjamín
Published: July 2023

El presente artículo tiene como principal objetivo ofrecer una aproximación operativa al complejo marco regulatorio del sector vitivinícola español, con el fin de examinar las principales actuaciones de política económica llevadas a cabo en dicho ámbito a lo largo de los últimos años. Con este propósito, el trabajo se ha estructurado en tres apartados. En el primero, de carácter introductorio, se destaca el peso del subsector vinícola dentro de la industria agroalimentaria española y se ofrece una breve caracterización del mismo. El segundo, contiene una visión sintética del extenso marco legal que afecta al sector a nivel nacional, en la que se subrayan los aspectos más significativos de aquellas normas que, dentro de ese intrincado mosaico jurídico, revisten una mayor trascendencia cara a la regulación de las diferentes fases de la cadena de valor vitivinícola. En el tercero, se detallan las principales acciones de política económica que, en los diferentes eslabones de dicha cadena de valor, tienen especial incidencia en la estructura y funcionamiento del sector.
A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer
Authors: Bockorny Bruno , Muthuswamy Lakshmi , Huang Ling , Hadisurya Marco , Lim Christine Maria , Tsai Leo L. , Gill Ritu R. , Wei Jesse L. , Bullock Andrea J. , Grossman Joseph E. , Besaw Robert J. , Narasimhan Supraja , Tao W. Andy , Perea Sofia , Sawhney Mandeep S. , Freedman Steven D. , Hidalgo Manuel , Iliuk Anton , Muthuswamy Senthil K.
Published: July 2023

Pancreatic cancer has the worst prognosis of all common tumors. Earlier cancer diagnosis could increase survival rates and better assessment of metastatic disease could improve patient care. As such, there is an urgent need to develop biomarkers to diagnose this deadly malignancy earlier. Analyzing circulating extracellular vesicles (cEVs) using ‘liquid biopsies’ offers an attractive approach to diagnose and monitor disease status. However, it is important to differentiate EV-associated proteins enriched in patients with pancreatic ductal adenocarcinoma (PDAC) from those with benign pancreatic diseases such as chronic pancreatitis and intraductal papillary mucinous neoplasm (IPMN). To meet this need, we combined the novel EVtrap method for highly efficient isolation of EVs from plasma and conducted proteomics analysis of samples from 124 individuals, including patients with PDAC, benign pancreatic diseases and controls. On average, 912 EV proteins were identified per 100µL of plasma. EVs containing high levels of PDCD6IP, SERPINA12 and RUVBL2 were associated with PDAC compared to the benign diseases in both discovery and validation cohorts. EVs with PSMB4, RUVBL2 and ANKAR were associated with metastasis, and those with CRP, RALB and CD55 correlated with poor clinical prognosis. Finally, we validated a 7-EV protein PDAC signature against a background of benign pancreatic diseases that yielded an 89% prediction accuracy for the diagnosis of PDAC. To our knowledge, our study represents the largest proteomics profiling of circulating EVs ever conducted in pancreatic cancer and provides a valuable open-source atlas to the scientific community with a comprehensive catalogue of novel cEVs that may assist in the development of biomarkers and improve the outcomes of patients with PDAC.
The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion
Authors: Nasir Apsra , Camacho Sharon , McIntosh Alec T. , Graham Garrett T. , Rahhal Raneen , Huysman Molly E. , Alsharief Fahda , Riegel Anna T. , Pearson Gray W.
Published: July 2023

Phenotypic heterogeneity promotes tumor evolution and confounds treatment. Minority subpopulations of trailblazer cells enhance the heterogeneity of invading populations by creating paths in extracellular matrix (ECM) that permit the invasion of phenotypically diverse siblings. The regulatory programs that induce a trailblazer state are poorly understood. Here, we define a new Tgfβ induced trailblazer population that is more aggressive than previously characterized Keratin 14 expressing trailblazer cells. Rather than triggering a binary switch to a single trailblazer state, Tgfβ induced multiple unique states that were distinguished by their expression of regulatory transcription factors, genes involved in ECM reorganization and capacity to initiate collective invasion. The integration of a parallel Egfr signaling program was necessary to induce pro-motility genes and could be targeted with clinically approved drugs to prevent trailblazer invasion. Surprisingly, Egfr pathway activity also had the collateral consequence of antagonizing the expression of a cohort of Tgfβ induced genes, including a subset involved in ECM remodeling. Together, our results reveal a new compromise mode of signal integration that promotes a trailblazer state and can be therapeutically targeted to prevent collective invasion.
Identification of 1600 replication origins in S. cerevisiae
Authors: Foss Eric J. , Lichauco Carmina , Gatbonton-Schwager Tonibelle , Lofts Brandon , Lao Uyen , Bedalov Antonio
Published: July 2023

There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood. In particular, these sites are made competent to initiate replication by loading of the Mcm replicative helicase prior to the start of S phase; thus, “a site to which MCM is bound in G1” might be considered to provide an operational definition of a replication origin. By fusing a subunit of Mcm to micrococcal nuclease, a technique referred to as “Chromatin Endogenous Cleavage”, we previously showed that known origins are typically bound by a single Mcm double hexamer, loaded adjacent to the ARS consensus sequence (ACS). Here we extend this analysis from known origins to the entire genome, identifying candidate Mcm binding sites whose signal intensity varies over at least 3 orders of magnitude. Published data quantifying the production of ssDNA during S phase showed clear evidence of replication initiation among the most abundant 1600 of these sites, with replication activity decreasing in concert with Mcm abundance and disappearing at the limit of detection of ssDNA. Three other hallmarks of replication origins were apparent among the most abundant 5,500 sites. Specifically, these sites (1) appeared in intergenic nucleosome-free regions that were flanked on one or both sides by well-positioned nucleosomes; (2) were flanked by ACSs; and (3) exhibited a pattern of GC skew characteristic of replication initiation. Furthermore, the high resolution of this technique allowed us to demonstrate
in vivo
that, as is the case
in vitro
, the Mcm complex is loaded directionally downstream of the ACS. We conclude that DNA replication origins are at least 3-fold more abundant than previously assumed, and we suggest that replication may occasionally initiate in essentially every intergenic region. These results shed light on recent reports that as many as 15% of replication events initiate outside of known origins, and they reveal S phase in yeast to be surprisingly similar to that in humans.
Imputation of 3D genome structure by genetic-epigenetic interaction modeling in mice
Authors: Kuffler Lauren , Fortin Haley J. , Skelly Daniel A. , Czechanski Anne , Munger Steven C. , Reinholdt Laura G. , Baker Christopher L. , Carter Gregory W.
Published: July 2023

Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. Analyses of these interactions has previously been limited, obscuring their regulatory context, and the extent to which they occur throughout the genome. Here we undertake a genome-scale analysis of these interactions in a genetically diverse population to systematically identify global genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure. We establish the extent and structure of genotype-by-epigenotype interaction using embryonic stem cells derived from Diversity Outbred mice. This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. We found that these interactions occur within the local area of the affected gene, and that this locality corresponds to topologically associated domains (TADs). The likelihood of interaction was most strongly defined by the three-dimensional (3D) domain structure rather than linear DNA sequence. We show that stable 3D genome structure is an effective tool to guide searches for regulatory elements and, conversely, that regulatory elements in genetically diverse populations provide a means to infer 3D genome structure. We confirmed this finding with CTCF ChIP-seq that revealed strain-specific binding in the inbred founder mice. In stem cells, open chromatin participating in the most significant regression models demonstrated an enrichment for developmental genes and the TAD-forming CTCF binding complex, providing an opportunity for statistical inference of shifting TAD boundaries operating during early development. These findings provide evidence that genetic and epigenetic factors operate within the context of three-dimensional chromatin structure.
Octopamine integrates the status of internal energy supply into the formation of food-related memories
Authors: Berger Michael , Auweiler Katrin , Tegtmeier Michèle , Dorn Katharina , El Khadrawe Tanna , Scholz Henrike
Published: July 2023

The brain regulates food intake in response to internal energy demands and the availability of food. However, can internal energy storage influence the kind of memory that is formed? We show that the duration of starvation determines whether Drosophila melanogaster forms appetitive short-term or long-term memory. The internal glycogen storage in the muscles and fat tissue influences how long sucrose is remembered. Insulin-like signaling in octopaminergic reward neurons integrates internal energy storage into memory formation. In turn, octopamine suppresses the formation of long-term memory. Octopamine is not required for short-term memory, since octopamine-deficient mutants form appetitive short-term memory to sucrose and to other nutrients depending on the internal energy status. The reduced positive reinforcing effect of sucrose in the presence of high internal glycogen levels combined with the increased stability of food-related memories due to increased starvation periods might drive increased food intake.
Repeatability of adaptation in sunflowers: genomic regions harbouring inversions also drive adaptation in species lacking an inversion
Authors: Soudi Shagheyegh , Jahani Mojtaba , Todesco Marco , Owens Gregory L. , Bercovich Natalia , Rieseberg Loren H. , Yeaman Sam
Published: July 2023

Local adaptation commonly involves alleles of large effect, which experience fitness advantages when in positive linkage disequilibrium (LD). Because segregating inversions suppress recombination and facilitate the maintenance of LD between locally adapted loci, they are also commonly found to be associated with adaptive divergence. However, it is unclear what fraction of an adaptive response can be attributed to inversions and alleles of large effect, and whether the loci within an inversion could still drive adaptation in the absence of its recombination-suppressing effect. Here, we use genome-wide association studies to explore patterns of local adaptation in three species of sunflower:
Helianthus annuus
,
H. argophyllus
, and
H. petiolaris
, which each harbour a large number of species-specific inversions. We find evidence of significant genome-wide repeatability in signatures of association to phenotypes and environments, which are particularly enriched within regions of the genome harbouring an inversion in one species. This shows that while inversions may facilitate local adaptation, at least some of the loci involved can still make substantial contributions without the benefit of recombination suppression. While a large number of genomic regions show evidence of repeated adaptation, most of the strongest signatures of association still tend to be species-specific, indicating substantial genotypic redundancy for local adaptation in these species.
Analysis of NIH K99/R00 Awards and the Career Progression of Awardees
Authors: Woitowich Nicole C , Hengel Sarah R , Vilgalys Tauras P , Babdor Joël , Tyrrell Daniel J
Published: July 2023

Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to five years. Using NIH data for the period 2006-2022, we report that ∼230 K99 awards were made every year, ∼40% of K99 awardees were women, and that ∼85% of K99 awardees went on to receive an R00 award. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the US.
Fachada variable: Solución para un edificio de muro cortina en Santiago
Authors: De la Barra Luegmayer Pedro Pablo , Vásquez Zaldívar Claudio
Published: July 2023

No presenta resumen.
¿Documentos o acontecimientos? Obras efímeras del Museo de la Solidaridad 1971-1973
Authors: García Isabel
Published: July 2023

No presenta resumen.
Fachada variable: Método para aplicar una fachada dinámica en Santiago
Authors: Vásquez Claudio , D'Alençon Renato , De la Barra Pedro Pablo
Published: July 2023

No presenta resumen.
Centralismo y formas fluidas de planificación territorial en chile: Mecanismos de gobernanza horizontal para la agenda urbana local
Authors: Marshall Catalina
Published: July 2023

No presenta resumen.
Montserrat Palmer y la voluntad de poder: Una voz femenina en el discurso de la arquitectura chilena
Authors: Mondragón López Hugo , Rozas Reinecke Bárbara
Published: July 2023

No presenta resumen.