bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Morphological Variations of Canal and Root of First Mandibular Molar in Tomographic Images Computer with Cone Beam in Patients of Arak City
Authors: Kianifar Mahsa
Published: March 2023

Introduction: Being the first teeth to erupt, first molars have the most complex root system and canal morphology and are among the most susceptible teeth to decay and destruction. The aim of this study is to determine the frequency of morphological variations of the canal and root of the mandibular first molar in cbct images so that appropriate treatment can be performed with a better understanding of the anatomy of the root and canal of the molar tooth.Materials & Methods: In this descriptive cross-sectional study, the morphological variation of the mandibular first molar canal and root was investigated in 170 cbct radiology image samples. In this study, the age and gender of the individual, the number of roots and canals of the mandibular first molar, the morphology of the canal in each root, the presence of the midmesial canal and the presence of the distolingual root were also investigated. In the end, frequency and percentage indicators were used to analyze data and chi-square test was used to compare frequencies.Results: The average age of the subjects studied was 39.2 years. The subjects included 86 women and 84 men. The most seen sample was a molar tooth with two roots and three canals. In terms of canal morphology in the mesial root, the most common canal morphology was type 4 and then type 2. In terms of canal morphology in the distal root, the most common canal morphology was type 1. In the studied samples, midmesial canal was not found in 99.4% of cases and distolingual root was not found in 94.7% of cases.Conclusion: Two-rooted and three-channel molar without midmesial canal and without distolingual root was the most common case found in this study. The most common canal morphology in the mesial root was type 4 and the most common canal morphology in the distal root was type 1.
Cytotoxicity Effects of Polyhydroxybutyrate/Chitosan/Bioglass Nanocomposite Scaffolds on Human Osteoblast-like Cells (SAOS-2 Cells)
Authors: Hashemi-Beni Batool , Khoroushi Maryam , Karbasi Saeed , Heidari Fariba , Foroughi Mohamad Reza
Published: March 2023

Introduction: In tissue engineering, a porous material is applied as the extracellular matrix or scaffold for cell growth. Then growth factors are added to this scaffold whose cytotoxicity must be assessed. In this study, the cytotoxicity effects of polyhydroxybutyrate/chitosan/bioglass nanocomposite scaffolds on human osteoblast like cells (SAOS-2 cells) are explored.Materials & Methods: This study was experimental and was done in Isfahan Dental School. The polyhydroxybutyrate/chitosan/bioglass nanocomposite scaffold was fabricated using the electrospinning method. Scanning Electron Microscopy (SEM) analysis was used to evaluate the morphological characteristics of the nanofibers and their diameter distribution. Additionally, bioglass nanoparticles in the fibers were identified via SEM. The MTT assay was performed to assess cell viability after 3, 5, and 7 days. The collected data were analyzed using SPSS 20.0 through statistical tests including Kruskal-Wallis test (p value ≤ 0.05).Results: According to SEM images, the scaffold fibers were fully porous and no beads were observed. Furthermore, the polyhydroxybutyrate/chitosan/bioglass scaffold showed greater cell viability and proliferation compared to the groups lacking bioglass.Conclusion: The polyhydroxybutyrate/chitosan/bioglass scaffold has no cytotoxic effect on osteoblast– like cells.
Tourism as an opportunity to effectively counteract marginalisation. The case of the Italian national strategy for inner areas
Authors: Cotella Giancarlo , Vitale Brovarone Elisabetta
Published: March 2023

Remote rural areas are often rich in natural and landscape assets, which are in turn used as the main focus of tourism development strategies aiming at reverting their decline. However, mono-functional strategies hardly manage to achieve this goal, as in order to restore those structural conditions that are essential to liveability and local development it is necessary to engage in a more comprehensive approach. Acknowledging this challenge, the paper reflects on the possibility to include tourism within multi-level development strategies aimed at tackling marginalisation, drawing on the case of the Italian National Strategy for Inner Areas. More in detail, the authors analyse how the latter enables the integration of tourism-related actions into more comprehensive, place-based development strategies that act upon the peculiarities of the territories they focus on through a mix of top-down and bottom-up logics.
Unveiling forms of participation in the governance of UNESCO world heritage sites
Authors: Taormina Francesca , Bonini Baraldi Sara
Published: March 2023

This paper focuses on the issues of governance and participation of World Heritage sites. It inquiries how decision-making structures to locally managed World Heritage sites may encompass public participation. Through an in-depth qualitative approach, the paper analyses the World Heritage Arab-Norman Palermo and the Cathedral Churches of Cefalù and Monreale serial site (Italy). By examining the participatory dynamics that occurred during the creation and development of the selected World Heritage serial site, this paper reveals three coexisting forms of participation in WHsite decisions: inter-institutional agreement, social aggregation, and multi-actor collaboration. The main findings suggest that although formal decision-making arenas may be participative weakly, the unpacking of participatory practices in urban spaces uncovers a vibrant scene, as it emerges from the Cassaro Alto and Danisinni districts in the city of Palermo.
Planning sustainable tourism in UNESCO wine regions: the case of the Langhe-Roero and Monferrato area
Authors: Assumma Vanessa , Bottero Marta , Cassatella Claudia , Cotella Giancarlo
Published: March 2023

Tourism may be an important leverage for local development. At the same time, it may trigger unwanted effects, ranging from the congestion of services and infrastructures to the progressive deterioration of the assets that they plan to valorise. The article sheds light on this tension, discussing the multiple implications that increasing tourism fluxes generate in the vineyard landscape of Langhe-Roero and Monferrato, included in the UNESCO World Heritage List since 2014. The case study highlights the need to coordinate and enhance coherence among the existing planning and management instruments, towards the consolidation of a multi-level integrated territorial governance framework aimed at the sustainable spatial planning of tourism in the area.
Barriers and challenges to sustainable physical planning for mountain destinations and second-home developments in the mountain region of south-eastern Norway: the reign of governments or developers?
Authors: Tjørve Even , Tjørve Kathleen M. C. , Owusu Kelvin
Published: March 2023

The number of hotels in the mountains of south-eastern Norway has decreased over the last three decades, with a concurrent increase in the number of modern, privately-owned second homes. The growth of second-home villages and associated commercial activity has produced sustainability issues. The shift in the planning and development process from the local government to private developers has resulted in a piece-by-piece process with the loss of sight of long-term consequences. This short review discusses the causes of uncontrolled or poor planning of mountain regions; in particular, the neoliberal trend in physical planning and the problem of small local communities.
Understanding the impact of tourism on spatial growth for sustainable development of tourist destinations through the measure of land use efficiency
Authors: Nunna Tagore Sai Priya , Banerjee Ankhi
Published: March 2023

Increased visitor arrivals and improved work opportunities in the discussed destinations resulted in infrastructural development and settlement movements, culminating in the urbanisation of the locations. As a result of increased tourist flows and growing economic dependency on the tourism sector, the accommodation and other tourist infrastructure have contributed to a change in built-up areas considerably in tourist areas. Most green spaces in environmentally vulnerable locations are being filled with concrete due to a lack of appropriate spatial development guidelines, while urban areas are losing their authentic aspects. The paper attempts to understand spatial sustainability through the measures of land consumption rate and land-use efficiency in various types of tourist places. As a result, the study concludes that there is a strong link between growing urbanisation and changing visitor arrivals, as well as population change, and tourism has a substantial influence on spatial sustainability.
Effect of Feeding Green Microalgae and Bacillus subtilis on Growth Performance, Blood Metabolites and Nutrient Digestibility of Beef Bulls in Arid Subtropics
Authors: Suwaiegh Shaker B. AL
Published: March 2023

Background: Green microalgae and Bacillus subtilis have been known to promote productive and reproductive performances in ruminant species. The present study aimed to improve productive performance, nutrient digestibility and serum metabolites upon supplementation Bacillus subtilis and green microalgae under heat stress conditions. Methods: Eighty crossbreed beef bulls were allocated into four groups of 20 bulls each. The first group served as control, the second group was supplemented with 13 g/head/day of Bacillus subtilis, the third group was supplemented with 30 g/head/day of Dunaliella salina and the fourth group was supplemented with both B. subtilis and D. salina. Daily weight gain and total weight gain were estimated. Blood samples were collected at every four weeks of experimental period and metabolic profiles were measured. Result: Digestibility coefficients were improved in all treated groups compared to control. Body weight gains and feed efficiencies recorded higher value in Bacillus subtilis and microalgae group. The serum total protein were higher in green microalgae compared to other groups during weeks 8 and 12. Moreover, blood urea nitrogen was higher in all treatment groups compared to control at week 12. Microalgae and combination of both microalgae and Bacillus subtilis increased hemoglobin, red and white blood cells.
Knowledge of Information Security Awareness and Practices for Home Users: Case Study in Libya
Authors: Asker Hamida , Tamtam Abdalmonem
Published: March 2023

The abundance of information available through the Internet, mobile applications, and cloud computing has made it convenient for users to access a wide range of information. However, this convenience comes with a cost as this information is constantly at risk of being compromised by cybercriminals and hackers. While the recognition of the potential dangers of information security is increasing in developed countries, in regions like Libya in North Africa, the level of protection for this information is insufficient. The purpose of this study is to examine the various factors that may influence or affect the users’ practice and awareness at home. The investigated factors are policy, behavior, training, knowledge of IT and education. In order to accomplish the goals of this study, a quantitative methodology was implemented. Specifically, a survey was created to assess the correlation between key factors and security awareness and practices in the home environment. The survey attracted 220 respondents and analyzed using Bivariate/Pearson Correlation to determine the relationship between the independent variable and the dependent variable. The result of the study showed that there was a moderate positive correlation between policy, knowledge of IT and education with security awareness and practice, but behavior factor has a low correlation. These results indicated that security awareness and practice level of employees at home are mostly at the middle level. It is hoped that the present study provides an initial step to focus on security training sessions among higher education employees to reflect new knowledge on the importance of security training to increase the knowledge of information security. It is hoped that the findings of this study will serve as a starting point for further research and focus on providing security information for public, which will help to reflect new knowledge on the importance of security training and increase awareness of information security.
Cambios en la renta del suelo urbano por el uso de instrumentos normativos de ordenamiento territorial, localidad de chapinero, Bogotá, Colombia
Authors: Rojas Cesar Augusto , Bautista Yepes Agapito
Published: March 2023

La renta urbana del suelo es uno de los principales atributos del mercado de la vivienda que posibilitan la gestión del espacio público. Este artículo evalúa el efecto sobre la renta del suelo urbano en la localidad de Chapinero, Bogotá, Colombia, empleando el Decreto 120 de 2018, instrumento que posibilita el desarrollo de equipamientos colectivos en cualquier zona de la ciudad, incluso en las zonas donde las normas vigentes no lo permitían; lo que implica un cambio de uso y en algunas zonas, el aumento en la edificabilidad máxima, generándose así un mayor valor de suelo e incidiendo en la formación de renta. La determinación de la renta diferencial consistió en el análisis predial, normativo y la aplicación de los métodos residual y de comparación de mercado para la determinación de valores comerciales de bienes inmuebles, empleados para determinar los cambios en los valores del suelo antes y después del instrumento normativo. Consiguientemente, la gestión del suelo a partir del desarrollo de equipamientos colectivos en diferentes zonas de la ciudad es una oportunidad para que propietarios o promotores, tanto públicos como privados, implementen este tipo de uso, mejorando las condiciones de derecho a la ciudad de los habitantes en general, mediante la satisfacción de necesidades básicas complementarias al habitacional y el goce de espacios colectivos de uso público.
Versos cantados: imaginarios bordados en la obra de Chonon Bensho
Authors: Parga-León Angela Laura
Published: March 2023

La colección de imágenes producidas en los últimos cinco años por la artista visual Chonon Bensho exhibe una serie de paisajes bordados de acuerdo con las pautas de diseño tradicional shipibo konibo, bajo la elaborada técnica del kené. Nuestra proposición es que las escenas que se muestran permiten comprender la interacción entre palabra e imagen en la forma peculiar de representación visual que la imaginación productiva de la artista expone. Esta interacción verboicónica se expresaría esencialmente en la incidencia de los actos de habla y, en específico, del canto o poesía cantada en la construcción del bordado. Para el análisis de obra, entablamos el diálogo entre los componentes de esta última y las voces de la filosofía y teoría de la imagen europeas. Se busca una aproximación a los modos en que cada diseño shipibo rebasa la literalidad de la representación paisajística, consolidando su presencia icónica y a su vez, una intraimagen. Todo lo anterior, gracias a la correspondencia entre las metáforas del canto y la órbita simbólica de los bordados.
Mundo, milagro y ley en La bicicleta de Sumji de Amós Oz
Authors: Menassé Adriana
Published: March 2023

A partir de una lectura de La bicicleta de Sumji de Amós Oz, el presente ensayo reflexiona sobre la relación entre dos oposiciones paralelas: por un lado, el mundo entendido como engranaje sujeto a la necesidad, frente a su opuesto, el azar o “milagro”. Por el otro, el milagro mismo, en cuanto se refiere a un azar venturoso, contrapuesto a la ley del padre, orden de la ética que se convierte en espacio de responsabilidad en la creación de un mundo justo. Estas oposiciones no son excluyentes sino a veces, incluso, complementarias; funcionan, más bien, como polos de una ecuación donde ninguno de los términos anula a su contario. Sugerimos que si el milagro se muestra como interrupción propicia frente al rigor del mundo, es la ética la que permite fincar una confianza básica y una afirmación del mundo más alegre y duradera.
Axial compression behaviour of concrete-filled auxetic tubular short columns
Authors: Solak Kemal , Orhan Süleyman Nazif
Published: March 2023

Concrete-filled steel columns (CFSCs) are of great interest in the literature as they are capable of carrying higher loads by combining the exceptional qualities of steel and concrete. With auxetic materials being introduced to civil engineering applications, the influence of these materials on CFSCs remains a matter of curiosity. The current study implements a nonlinear finite element analysis to evaluate the performance of circular CFSCs with six auxetic tubes under axial compression and the proposed numerical model was validated using published experimental data. The effect of the auxetic steel tube’s porosity and Poisson’s ratio on CFSCs was examined parametrically in terms of ultimate strength using the confined concrete model. Moreover, the stress distributions of the concrete and the auxetic steel tubes were also thoroughly examined. Based on the findings of the analysis, the ultimate load of CFSCs, utilising auxetic tubes with the same density and porosity but different Poisson’s ratio, increased proportionally with the increase of auxetic behaviour. When it comes to auxetic tubes with different densities and porosities, the influence of the Poisson’s ratio of the tubes diminished and the stiffness of tubes became more dominant over the mechanical characteristics of columns as the density of the auxetic steel tubes increased or decreased. The stiffness of the auxetic tubes reduced as porosity increased, as did the ultimate load of the columns. Additionally, the ultimate loads of the auxetic steel tube columns are found to be lower than those of bare steel tube columns filled with concrete due to perforations.
Natural frequencies of porous orthotropic two-layered plates within the shear deformation theory
Authors: Turan Ferruh
Published: March 2023

This paper analyzes the natural frequencies of porous orthotropic laminated composite plates with two different porosity models based on the higher-order shear deformation theory. The fundamental relations of natural frequency analysis are derived by using the virtual work principle and hyperbolical shear deformation theory. The obtained partial differential equations system is reduced to an ordinary differential equations system via approximation functions suitable for simply supported boundary conditions and the Galerkin method. After some mathematical operations, the natural frequency equation of porous orthotropic laminated composite plates is obtained in the framework of hyperbolical shear deformation theory. The natural frequency equation based on the classical laminated plate theory can be determined by ignoring the shear strains in the theoretical formulations. After two validation studies by using appropriate results in the literature, parametric analyses are performed to show the sensitivity of natural frequencies to shear deformation, porosity model, orthotropy, layer sequence, and geometric properties.
Analisis Yuridis Mengenai Tanggung Jawab Notaris Dan Dalam Perkara Mafia Tanah
Authors: Miranda Este
Published: March 2023

The population growth and development is increasing rapidly while the land area is not increasing and economic growth is not moderate in Indonesia, which requires the community to make efforts and justify any means so as not to fall into this situation, one of which is land mafia practices involving notaries as the competent authority in legal implementation. The formulation of the problem is, first, what are the parameters or benchmarks for legal responsibility for notaries involved in land mafia cases? Second, what are the legal consequences for a notary involved in a land mafia case? This type of research is normative research with statutory and conceptual approaches. The results of this study conclude that first, a notary can be held responsible for their actions in terms of conspiring to commit land mafia practices. Second, from their actions, the notary can receive legal consequences through three mechanisms, namely civil, administrative and criminal
Keabsahan Akad Perbankan Syariah Dengan Pengikatan Jaminan Hak Tanggungan
Authors: Soimah Siti
Published: March 2023

This research examines the problems of guaranteeing Mortgage Rights in Islamic Financing. This type of research is normative legal research, examined using a statutory approach, conceptually analyzed qualitatively. The results of the analysis carried out conclude that the validity of the Islamic Banking Contract with the Binding of Mortgage Guarantees based on Surah Al-Baqarah verse 283 shows that material guarantees are permitted. Whereas legally stated in the Fatwa of the Indonesian National Sharia Council number 25/DSN/MUI/III/2002 on al-Rahn which provides an explanation regarding the ijma' of the scholars that al-rahn contracts or debt guarantees are broadly permissible. The use of guarantees in Islamic banking contracts prioritizes the application of the ijtihad method but does not intend to override the original law but is based more on the principle of using the istihsan method. The virtue of the istihsan method is to realize the benefit and avoid the dangers. Mortgage has executive power, this power is equated with a court decision or known as the principle of parate execution, this is what makes the istihsan method more often used. When viewed further, the imposition of mortgage rights on Islamic banking contracts basically should not be equated with the imposition of mortgage rights on conventional banking, both should have different principles. If the installation of the Mortgage is to guarantee mudharib trust, then the Mortgage is declared valid. with the consequence that in the event of a default it is not immediately auctioned off, in other words the principle of parate execution is not necessarily carried out. Then the Mortgage if used as a guarantor for the return of capital of the shahibul maal becomes invalid and null and void by law. These two aspets can determine the validity of the sharia banking contract with the binding of the Mortgage guarantee.
Penggunaan Surat Kuasa Menjual Pada Objek Jaminan Yang Dibebani Hak Tanggungan Dalam Perjanjian Kredit Perbankan
Authors: Prayoga Harry Dwicha
Published: March 2023

This research aims to analyze how the legal consequences of using a Power of Attorney to Sell which is used as the basis of an alternative execution of guarantees that have been bound with Mortgage for creditors (banks). Therefore, the author divides the main issue into 2 (two) parts, first, whether the use of a Power of Attorney to Sell against collateral objects that have been bound with Mortgage can be used as an alternative execution in guaranteeing certainty of the fulfillment of creditors' receivables related to debt agreements in banking credit. Second, what are the legal consequences of using a Power of Attorney to Sell against collateral objects that have been burdened with Mortgage Rights in the loan agreement for Creditors (banks)? This is a normative-qualitative research which is supported by primary legal materials and secondary legal materials. The approaches used by the author is in the form of a statutory and a conceptual approaches. The results of this study conclude that first, that the power of attorney to sell cannot be used as an alternative for execution on mortgage guarantees, since collateral that has been bound with mortgage rights will be subject to Law Number 4 of 1996 on Mortgage Rights. Second, the legal consequences arising from the use of the Power of Attorney to Sell are not binding, meaning that according to the provisions of Article 1320 of the Civil Code paragraph 4 on "lawful causes", the subjective requirements of using the power of attorney to sell are not fulfilled and the legal consequences are null and void.
Implikasi Yuridis Agunan Yang Diambil Alih Oleh Perbankan Syariah Dalam Akad Murabahah
Authors: Permana Iva Latifah
Published: March 2023

To minimize the risk of problematic financing by the debtor, Islamic banks require collateral/guarantee in murabahah financing. Land rights are usually used as collateral objects which will then be burdened with Mortgage Rights. When the debtor defaults or defaults, Islamic banks can execute collateral against the collateral. One alternative for solving problem financing is through the Foreclosed Collateral (AYDA) process. This is a normative juridical research with the type of library research. The results of this study conclude that the settlement of troubled financing through Foreclosed Collateral (AYDA) if carried out under Article 12 A of the Banking Law, this has violated the provisions of Article 12 of the Mortgage Law where the object of collateral/guarantee is not to be owned by the creditor, in in terms of the agreement made at the beginning between the sharia bank and the customer, in the implementation of the AYDA there has been a transfer of rights, the implications for the agreement in the murabahah contract are deleted or cancelled.
On the Thermodynamics of Matter
Authors: Kumar Naman
Published: March 2023

The holographic principle states that the information about the volume of space is stored on its boundary. Assuming this holds, we can explain the aspects of gravity. It strongly seems that ”information” is a more fundamental entity than the structure of spacetime as used as basis in almost every gravity theory. In this paper, we present this connection between gravity and information. This naturally explains the four classical tests of gravity namely the gravitational redshift, the perihelion precession, the bending of light and the gravitational time delay. The spacetime need to be extended to 5D to explain gravity in this context. We also show that the second derivative of the radius of a null boundary(with respect to an affine parameter λ along the generator) that encloses matter obeying the null energy condition(NEC) cannot decrease. This can be applied to the event horizon of a black hole.
Comprehensive Study of The Cloud Computing Service Providers
Authors: Alhosani Khalifa , Hosameldeen Osama
Published: March 2023

Whether it’s cellphones, personal computers, or gaming consoles, technology is a part of everyone’s everyday lives, and storage is frequently a problem. One of the solutions we have for this difficulty is the on-demand accessibility of computer framework assets, which enables cloud storage and makes it accessible in any format and from any device. It is a major benefit of cloud computing. Amazon Web Administrations (or basically AWS) may be a secure cloud services stage advertising about everything businesses ought to construct advanced applications with adaptability, versatility, and unwavering quality. Another advantage is that it is significantly less expensive than purchasing items with comparable functionality, such as an SSD storage device. For many enterprises, it is also preferable to host their servers in the cloud using services like Google Cloud and Oracle Cloud. Our main topic of the paper is to compare three different major cloud computing services—AWS, Google, and Azure. Since there are different types of cloud computing services available, we would compare them to determine which is best for usage by individuals or organizations. We can also look at the services’ shared features and unique aspects that they provide to consumers.
Predictors of Tetanus Vaccine Uptake among Pregnant Women in Sudan: A Hospital-Based Cross-Sectional Study
Authors: Ibrahim Zienab A , Sabahelzain Majdi , Elhadi Yasir Ahmed Mohammed , Oliver Ombeva , Babiker Suad
Published: March 2023

Tetanus toxoid (TT) vaccination during pregnancy has been proven as an effective preven-tive measure to reduce the incidence of maternal and neonatal morbidity and mortality worldwide. This study aimed to assess the determinants of TT vaccine uptake among pregnant women in two public maternity specialized hospitals in Sudan. A hospi-tal-based cross-sectional study was conducted in two public hospitals, Omdurman Ma-ternity and AL-Saudi hospitals in Omdurman, Khartoum State in Sudan, from February to April 2020. Logistic regression analysis was carried out to identify factors associated with receiving three or more doses of TT vaccine among pregnant women (protected against tetanus), presented as Odds ratios, with p-values <0.05 considered significant (at 95% confidence interval). The study recruited 350 pregnant women, with 313 participants in-cluded in the analysis. This study found that only 40% of the pregnant women received 3 doses or more (protected) of TT vaccine during their current pregnancy. Pregnant women who attended Al Saudi hospital were less likely to be protected against Tetanus (received ≥ 3 doses) compared to those who attended Omdurman hospital [OR= 0.49 (95%C.I 0.29-0.82), p-value <0.05]. Furthermore, the number of children at home was a significant predictor of mothers’ immunization status as those with five children or more were ten times more to be protected against tetanus [OR= 10.54 (95% C.I 4.30-25.86), p-value <0.05]. We conclude that this low rate of TT vaccine uptake found in this study among pregnant women increases the number of newborn babies susceptible to contracting neonatal tetanus. This study provides useful information that can inform the will increase in the probabilities of morbidities and mortalities that result from maternal and neonatal tetanus. The findings of this study should be considered in development of communication strategies targeting and prioritizing at-risk groups to increase TT vaccine uptake among pregnant women in Sudan.
CENPA Was a Cell Cycle Biomarker in Cancers With Diagnostic Prognostic, and Therapeutic Value
Authors: Liu Hengrui , Tang Tao
Published: March 2023

Background Cancer is one of the most concerning public health issues in the world. One of cancer hallmarks wildly accepted is sustaining proliferative signaling, which involved most of the cell cycle biological activities. Centromeric histone, Centromere Protein A (CENPA), a variant of canonical histone H3, plays an essential role in selective chromosome segregation in the cell cycle. However, so far, a systematic pan-cancer bioinformatic analysis has not been done yet. Methods We accessed genome, transcriptome, and clinical information from open databases. The genetic alteration, mRNA expression, functional enrichment, stemness, mutation association, expression in cell populations and cellular locations, cell cycle association, survival association of CENPA, and immune association were analyzed. A prognostic model for glioma patients was constructed as an example application of CENPA as a biomarker. Drugs targeting CENPA in cancer cells were also screened and predicted by the CENPA correlation of drug sensitivity and protein-ligand docking. Results CENPA had low gene mutation in cancers. CENPA was overexpressed in almost all cancer types in TCGA compared to their normal control. CENPA was highly expressed in the nucleus of malignant cells. CENPA was associated with the cell cycle of cancer cells. CENPA is a biomarker for the cell cycle G2 phase in cancer cells. CENPA was a diagnostic and prognostic biomarker across multiple cancer types. The prognosis of glioma with CENPA was reliable and can be applied with other prognostic factors. CENPA was associated with the immune microenvironment. Drugs CD-437, 3-Cl-AHPC, Trametinib, BI-2536, and GSK461364 were predicted to target CENPA in cancer cells. Conclusion CENPA was a cell cycle biomarker in cancers with diagnostic and prognostic value.
Dark Energy Can be Delivered to the Universe by Stochastic Nonlinear Gravitational Waves Coming from “Nowhere“
Authors: Marochnik Leonid
Published: March 2023

It is shown that de Sitter accelerated expansion of the Universe (dark energy effect) is an exact solution to the set of self-consistent stochastic nonlinear gravitational waves in the FLRW metric coming to the Universe from “nowhere”.
Enhancing Oil Recovery by Polymeric Flooding with Purple Yam and Cassava Nanoparticles
Authors: Al-Jaber Hasanain A. , Arsad Agus , Tahir Muhammad , Nuhma Mustafa Jawad , Bandyopadhyay Sulalit , Abdulmunem Abdulmunem R. , Abdul Rahman Anis Farhana , Harun Zakiah binti , Augustine Agi
Published: March 2023

Significant amount of oil remains in the reservoir after primary and secondary operations and to recover the remaining oil, enhanced oil recovery (EOR) can be applied as one of the feasible options remaining nowadays. In this study new nano polymeric materials have been prepared from purple yam and cassava starches. The yield of purple yam nanoparticles (PYNPs) was 85% and that of cassava nanoparticles (CSNPs) is 90.53%. Synthesized materials were characterized through particle size distribution (PSA), zeta potential distribution, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and transmission electron microscopy (TEM). The performance of PYNPs in recovering oil was better than CSNPs as found from recovery experiments. Zeta potential distribution results confirmed the stability of PYNPs over CSNPs (-36.3 mV for PYNPs and -10.7 mV for CSNPs). The optimum concentration for these nanoparticles has been found from interfacial tension measurements and rheological properties and it was 0.60 wt.% for PYNPs and 0.80 wt.% for CSNPs. More incremental recovery (33.46%) has achieved for the polymer that contained PYNPs in comparison to the other nano-polymer (31.3%). This opens the inception for a new technology for polymer flooding that may replace the conventional method that depends on partially hydrolyzed polyacrylamide (HPAM).
Adapted Business Model Canvas Template and Primary Market Research for Project-Based Learning on Management of Slurry
Authors: Moure Abelenda Alejandro , Aiouache Farid , Moreno-Mediavilla Daniel
Published: March 2023

Education is one of the most important tools available to policymakers and non-governmental bodies to promote a change in the behavior of society and to address the climate crisis, in line with the 4th and 13th Sustainable Development Goals of the United Nations 2030 Agenda. Project-based learning (PBL) addresses real and global challenges and allows the academic and professional formation of students. As part of the reflection stage of the educational action research method using the Business Canvas Model (BMC), pedagogic deficiencies were identified in the PBL and a didactic proposal was elaborated to emulate the interaction of students with the ecosystems of society. A prototype for improving the management of organic manures as soil amendments was initially developed, to provide the students with a quick start on the first steps of the proposed project. In the 10 sessions designed for the PBL (Make it happen!), the students elaborate a more sophisticated artifact in response to the demands of potential clients, as per the outcomes of the primary market research (5th session). Active teaching methods and tools, such as a modified template of the BMC with the Rumsfeld’s matrix, aid the metacognition of students and their competences development. In a double session of the PBL, the primary market research is organized with key stakeholders of the agroindustry to enquire about the feasibility of the implementation of the technological solution and the logistics at farm level. Finally, the evaluation relies on the suitability of the upgraded prototype to respond customers’ demands.
Pueraria thomsonii Radix Water Extract Alleviates Type 2 Diabetes Mellitus in db/db Mice through the Integrated Regulation of Metabolism and Gut Microbiota
Authors: Li Jiarong , Liu Yuhui , Ouyang Hui , Sun Yong , Zhong Youbao , Wang Lifang , Huang Jiaxing , Chen Junchang , Tan Xiangyan , Li Mingyao , Hu Yue , Zhang Hua , Liu Ronghua
Published: March 2023

Type 2 diabetes mellitus(T2DM) is an increasingly prevalent and serious health problem. Its onset is typically associated with metabolic disorders and disturbances in the gut microbiota. Previous studies have reported the anti-T2DM effects of Pueraria thomsonii Radix as a functional food. However, the mechanism of action is still unknown. In this study, the effects of Pueraria thomsonii Radix water extract(PTR) on db/db mice were evaluated by pharmacology, metabolomics, and 16S rRNA gene sequencing. The results showed that PTR could improve the body weight of mice, reduce fasting blood glucose(FBG), urinary glucose(UGLU), homeostasis model assessment insulin resistance(HOMA-IR), urinary albumin/creatinine ratio(UACR), and reduce pancreatic tissue damage. Metabolomics showed that the Model group produced 109 differential metabolites, of which 74 could be regulated by PTR. 16S rRNA sequencing was done in fecal samples and results showed that PTR could reduce the Firmicutes/Bacteroidetes ratio(F/B) associated with obesity and regulate 3 beneficial bacteria and 1 harmful bacteria. In conclusion, the results showed that PTR could ameliorate T2DM symptoms, metabolic disorder, and gut microbiota imbalance of db/db mice, and it was superior to metformin in some aspects. We suggested for the first time that γ-aminobutyric(GABA) may be involved in the regulation of the microbiota-gut-brain axis(MGB) and thus affect the metabolic disorders associated with T2DM. This study will provide a scientific basis for the development of functional food with PTR.
Extracellular Vesicle microRNA Biomarkers of Late Post-sepsis Survivors
Authors: Souza-Siqueira Talita , Gritte Raquel Bragante , Weimann Eleine , Vieira Juliana de Camargo , Masi Laureane Nunes , Borges Fernanda Teixeira , Borges Rodrigo Cerqueira , Murata Gilson Masahiro , Oliveira Laiane Cristina dos Santos de , Bordin Silvana , Silva Eliane Borges da , Gorjão Renata , Levada-Pires Adriana Cristina , Nogueira Antônio Carlos , Pithon-Curi Tânia Cristina , Azevedo Ricardo Bentes , Curi Rui , Machado Marcel Cerqueira Cesar , Soriano Francisco Garcia
Published: March 2023

Sepsis is a life-threatening condition with high hospital mortality. Elevated mortality has also been observed in patients after hospital discharge due to post-sepsis syndrome (PSS). The etiology of PSS is still not entirely known, but it involves inflammation. Plasma extracellular vesicles (EVs) are recognized as a unique mechanism of intercellular communication in inflammatory processes. It has been reported that EV microRNA (miRNA) production during the acute sepsis phase may persist until after disease resolution and is associated with PSS.
We employed mass spectrometry and qPCR analysis to determine the protein and miRNA composition of plasma-derived EVs of 36 patients during sepsis-related hospitalization, immediately after ICU discharge (post-sepsis), and three, six, twelve, and up to 36 months post-sepsis.
We determined that patients’ immune system cells were the primary EV source. Fifteen differentially expressed EV miRNAs (DEmiRs) were identified in samples from septic patients compared to the control group. Predictive analyses revealed that these DEmiRs could influence inflammation by modulating pathways mediated by NF-κB, STAT3, and TLR4 signaling activation. Thirteen miRNAs (-15b-5p,-16-5p,-20a-5p,-25-3p,-27a-3p,-29a-3p,-30d-5p,-93-5p,-146a-5p,-148a-3p,-191-5p,-195-5p,-223-3p) were downregulated in the death group compared to the survivor group, making them candidate prognostic markers of ICU survival. One year after ICU discharge, the expression of miR-21-5p and miR-195-5p were decreased in the survivor group.
The miRNAs identified in the present study represent potential biomarkers for the survival prognosis of post-sepsis patients.
Depression Associated With Intrafamily Violence in Pregnant Women Treated at a Peruvian Health Center, 2022
Authors: Cardenas-Barrios Ximena , Zagaceta-Guevara Zaida , Moquillaza-Alcantara Victor
Published: March 2023

Violence can promote various mental complications such as depression, however, the type of violence that promotes it has not been estimated in detail. The purpose of this study was to assess whether depression is associated with domestic violence in pregnant women treated at a Peruvian health center, 2022. A quantitative, observational, cross-sectional analytical study. A total of 180 pregnant adults who attend the health facility in person were selected. Intrafamily violence was assessed using a questionnaire from the Ministry of Women and Vulnerable Populations of Peru and depression using the Beck Depression Inventory. The study has the approval of the ethics committee of the university and the permission of the head of the health establishment. 36.11% [95%CI: 29.39-43.43] of the pregnant women presented depression and 1.11% severe de-pression; likewise, 41.67% [95%CI: 36.64-49.05] reported having experienced domestic violence. It was identified that presenting domestic violence increases the probability of presenting depression during pregnancy (aPR: 9.89; p<0.001). The associated types of violence were psychological (aPR: 10.44; p<0.001) and physical (aPR: 1.78; p=0.007). There is an association between domestic violence and depression during pregnancy, the types of violence associated being psychological and physical.
A Concise Study on Essential Parameters for the Sustainability of Lagoon Waters in Terms of Scientific Literature
Authors: Kader Shuraik , Raimi Morufu Olalekan , Spalevic Velibor , Austin-Asomeji Iyingiala , Raheem Waliyyat Bukola
Published: March 2023

Lagoons are becoming sporadically utilised albeit they are equipped with high potential for the outsourcing of environmental and industrial benefits. It leads to the endangered pollution of lagoon water aquatic system. The prime reason is the lack of knowledge among stakeholders and researchers regarding the influential parameters in establishing the lagoon water quality. The optimal quality for lagoon water is critical for the longevity of aquatic ecosystem. This study focuses on using bibliographic references to find the most influential factors determining the water quality in lagoons for deriving a comprehensive long-term water quality monitoring plan to ensure the sustainability of the lagoon water ecosystem. The lagoon water quality was classified in this study into biological, physical, and chemical parameters and studied for their importance upon enhancing the water quality. Experiments were conducted on selected parameters using the water samples from the selected Sri Lankan lagoons with available facilities to observe the water quality. The overall findings on physiochemical and biological characteristics using the experiments temperature, turbidity, pH, salinity, DO, BOD, COD, phosphates, nitrates, ammonia content and faecal coliforms in water specimens suggest that the selected Sri Lankan lagoons are heavily polluted due to their distinctive variations from the allowable threshold limits specified in the literature sources. To increase such increased risks associated with lagoon water systems, a long-term monitoring strategy is recommended to be incorporated at lagoon waters in order to assure their sustainability.
The Expected Competitive Ratio on a Kind of Stochastic-Online Followtime Scheduling with Machine Subject to an Uncertain Breakdown
Authors: Li Zhenpeng , Cheng Congdian
Published: March 2023

We consider the problem of scheduling tasks on a single machine subject to an uncertain breakdown to minimize the flowtime. Assume the machine is unavailable during the breakdown; the starting time of the breakdown is a random variable s with distribution function D(s) and the terminating time of the breakdown has no any other information; jobs are non-resumable. Under the assumptions, starting from the perspective of statistical optimization, we first define the expected competitive ratio of an algorithm to find the optimized solution with the considered problem. Further, we propose and prove a certain result on the expected competitive ratio of the SPT rule. In particular, we show that under a quite loose condition the expected competitive ratio of the SPT rule is no more than 5/4. Meanwhile, we also make some discussions about our studies. What we have done will rich and improve the studying results on the area of scheduling to minimize flowtime and advance the development of online optimization and statistical optimization.
Integrated Polarisation Control in Microlens Arrays: Performance at Visible-Ir Spectral Ranges
Authors: Mu Haoran , Smith Daniel , Katkus Tomas , Gailevicius Darius , Malinauskas Mangirdas , Nishijima Yoshiaki , Stoddart Paul R , Ruan Dong , Ryu Meguya , Morikawa Junko , Vasiliev Taras A , Lozovski Valeri , Moraru Daniel , Ng Soon Hock , Juodkazis Saulius
Published: March 2023

Microlens arrays (MLAs) which are increasingly popular micro-optical elements in compact integrated optical systems were fabricated by femtosecond direct laser write (fs-DLW) technique in the low-shrinkage SZ2080TM photoresist. High fidelity definition of 3D surfaces on IR transparent CaF2 substrates allowed to achieve ∼ 50% transmittance at chemical fingerprinting spectral region 2-5 μm wavelengths since MLAs were only ∼ 10 μm high corresponding to the numerical aperture of 0.3 (the lens height is comparable with the IR wavelength). To combine diffractive and refractive capabilities in miniaturised optical setup, a graphene oxide (GO) grating acting as a linear polariser was also fabricated by fs-DLW by ablation of a 1 μm-thick GO thin film. Such an ultra-thin GO polariser can be integrated with the fabricated MLA to add dispersion control at the focal plane. Pairs of MLAs and GO polarisers were characterised throughout visible-IR spectral window and numerical modeling was used to simulate their performance. Good match between experimental results of MLA focusing and simulations was achieved.
From Dearth to Excess: The Rise of Obesity in an Ultra-Processed Food System
Authors: Hall Kevin
Published: March 2023

More people around the world now have obesity than suffer from starvation thanks to our modern food system. Agriculture was transformed over the 20th century by a variety of technological advancements that relied heavily on fossil fuels. In addition, government policies and economic incentives led to surplus production of cheap inputs to processed food industries that produced a wide variety of heavily marketed, convenient, rewarding, timesaving, and relatively inexpensive ultra-processed foods. The energy available in the food supply increased much more than population needs, albeit with large inequities in food distribution and nutrition security. While most of the rise in per capita food availability during the late 20th and early 21st centuries resulted in increased food waste, a variety of mechanisms have been proposed by which changes in the increasingly ultra-processed food environment resulted in excess energy intake disproportionately in people genetically susceptible to obesity. As populations continue to grow, substantial investments in coordinated nutrition and agricultural research are needed to transform our current food system to one that relies less on fossil fuels, preserves biodiversity, ensures environmental health, and provides equitable access to affordable, safe, and nutritious food that reduces the prevalence of chronic diseases like obesity.
The Current Role and Future Applications of Machine Perfusion in Liver Transplantation
Authors: Staubli Sebastian Manuel , Ceresa Carlo D. L. , Pollok Jörg-Matthias
Published: March 2023

The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs. Currently, machine perfusion techniques have led to the improvement of the quality of marginal livers and to prolonged cold ischemia time and allowed for the prediction of graft function through analysis of the organ during perfusion, improving the rate of organ use. In the future, the implementation of organ modulation might expand the scope of machine perfusion beyond its current usage. The aim of this review was to provide an overview of the current clinical use of machine perfusion devices in liver transplantation and provide a perspective for future clinical use, including therapeutic interventions in perfused donor liver grafts.