bluuebunny/crossref_metadata_2025 huggingface dataset:
Senility and its inconveniences according to Speculum naturale by Vincent of Beauvais (Ab. 1194-1264)
Authors: Wojciechowska Beata
Published: August 2021

The stages of human life and the corresponding physiological changes have been described in many ways since ancient times. Although old age was characterized by physical and mental weakening (senility), it was portrayed as an age of wisdom which contrasted youth dominated by passions. Vincent of Beauvais devoted a few extensive chapters of Speculum Naturale to the last stage of life and cited works of Cicero, Aristotle, Horace, Virgil, St. Jerome, St. Ambrose, Avicenna, Isidore of Seville, which gave him a place in the intellectual tradition of his era. According to him, the advantages of old age were moderation in pleasures, lower libido, wisdom, maturity of advice, common sense and reconciliation to death. The negative aspects of senility were diseases, discouragement and drowsiness. The physical weakness of the body affected the stability of mind. Vincent recognized old age as a natural period in human life and characterized it from the philosophical and medical points of view. He chose those pieces of writings which he considered important and representing different aspects of old age. He advised on nutrition, strengthening of the body and mental energy. Vincent emphasized that old age should be considered as fate. Therefore, there is no reason to fall in despair and wallow in hopelessness, but prepare for death through a wise life.
Good neighborhood confirmed by an indigenate – three cases of moldavian hospodars in the 17th century
Authors: Milewski Dariusz
Published: August 2021

Moldavia in modern age – especially in 16th and 17th centuries – being a tributary to the Ottoman Empire – still caught Polish attention. Both Poles and Turks considered Moldavia as a buffer which needed their attention. Such a situation allowed more ambitious hospodars to balance and keep as large an autonomy as it possibly could. Although Moldavian hospodars had to obey to the Porte, they often kept close diplomatic and even military relationships with Poland. Giving Polish indigenous to hospodars was a good way to keep them in obedience to Poland. This honour was given – among the others – to Miron Barnovski, Vasile Lupu and Gheorghe Ştefan. All these hospodars – although they fought against each other – saw in Poland a guarantor of their power. This article discusses the policy of these hospodars toward Poland and focuses on the circumstances of giving Polish indigenous to these rulers. The article also signals some historical principles ruling the actions of Poles, Moldavian and Turks in this difficult period.
International order in the ideology of the Knights’ Order of Cross and Sword during the Second World War
Authors: Miszewski Dariusz
Published: August 2021

During the Second World War The Military Order of the Cross and the Sword combined Catholic moral principles with patriotism in the active struggle for independence. The role of enlarged strategically Poland was peaceful integration of Central Europe. They planned to follow rules of peaceful Catholic international cooperation. Anti- Christian systems of Germany and the USSR and materialistic western countries were not acceptable.
John of Capistrano in Jan Długosz’s Annales...
Authors: Kowalska Barbara
Published: August 2021

Jan Długosz in his cards made a presentation of Annales…fifteenth century priest and reformer – Jan Kapistran. My purpose was to show the characteristic this person, something valued by chronicle writers. Długosz used different methods, to convince the reader about the concepts of hero sainthood, for example descriptions such as: famous, reverend, smart - which came from the catalog, which were used by the author many times, symbolical, numbers – three, forty, a hundred, which enforce a belief, that next to Jan amazing things are happening. Miracle making, prediction, healing, gift of tiers most appeared in this source biography. Comparing the preacher to St. Augustine strengthened the belief in the sanctity of the hero.
Jan Ludwik Popławski’s fascination with the Polish ‘Common People’
Authors: Kowalczyk Michał
Published: August 2021

Jan Ludwik Popławski (1854-1908) was one of the fathers of the Polish National Democratic ideology in the late 19th and early 20th century. He was particularly fascinated with matters pertaining to the common people, and especially Polish peasantry. He considered them to be the genuine Poles, free of foreign influences. It is worth pointing out that that he also served as an inspiration to Roman Dmowski, the founder of the National Democracy movement and one of the leaders whose efforts secured Polish independence. According to Popławski, the Polish gentry were servile to the powers occupying Poland. He therefore hoped that the common people would play a greater role in the political life of the nation.
Efforts of crossing the German blockade of Polish coast by sea 1 Sept. – 2 Oct. 1939
Authors: Sykut Piotr
Published: August 2021

The article presents the attempts of Polish coast defenders' to get through to neutral countries by sea during military operations in September and October 1939. These efforts were made in spite of the German blockade of Polish coast by Kriegsmarine ships and Luftwaffe planes. This subject hasn't been widely featured yet using the reports of coast defenders kept in Polish and foreign archives. The goal of this article is the systematisation of knowledge about these facts, presentation of characters of sailors, soldiers and civilians, who didn't want to go into captivity. Some of them were going to continue their struggle in Polish Armed Forces in the West.
The Napoleonic epopee of polish soldiers in the art of Juliusz Kossak
Authors: Szeremietiew Oleg W.
Published: August 2021

The article addresses the oeuvre devoted to the Napoleonic Wars by eminent Polish battle painter and illustrator of the 2nd half of the 19th century, Juliusz Kossak (the founder of a dynasty of artists). Many of the artist’s pictures and watercolours show Polish soldiers, participants of the Epopee. They reflected not only the work and research of the master and his vision of the past, but also the patriotic idea of the revival of Poland and its nation.
Karol Wojtyła`s military career in the light of archival records
Authors: Kindziuk Milena
Published: August 2021

Little is known and studied of the military personal records of Karol Wojtyła from the Kriegsarchiv in Vienna, which would allow an accurate account of his curriculum vitae and map out the main steps in the course of his military service. Analysis of the above records leads to the conclusion that Karol Wojtyła Sr., John Paul II's father, was for 18 years a professional soldier in the service in the Austro-Hungarian Army, in the 56th Infantry Regiment called the Wadowice Regiment. Later he became an officer in the Polish Army in the reborn Republic of Poland. Throughout his military service he enjoyed a very good reputation and his superiors described him as diligent and honest, valued for his ability to communicate in German.
Tecnologia Liberdade ou prisão Uma visão neurocientífica
Authors: Dutra Vianna Deister Machado Rejane , Laport Tamires
Published: August 2021

O uso da tecnologia digital estimula o desenvolvimento da capacidade visual, da noção espacial e da coordenação motora, mas também pode trazer prejuízos. Estudos recentes demonstraram que esta atividade ativa áreas corticais importantes, como as funções executivas, que estão centradas no córtex pré-frontal, o qual é extremamente complexo por possuir conexões com outras regiões. O presente artigo tem como objetivo discutir um conjunto de evidências sobre a influência do excesso desta rede tecnológica nas dimensões de comportamento, cognição, afeto e excitação, tão bem quanto as principais regiões cerebrais alteradas. Para uma incursão a estes campos de investigação, a metodologia desse estudo foi uma revisão narrativa da literatura. A maioria das recompensas aumentam o nível de dopamina no cérebro, que é produzida especialmente pela substância negra e pela área tegmental ventral. Sendo assim, o uso excessivo da inteligência virtual causa uma liberação do neurotransmissor dopaminérgico, a dopamina. Este excesso confunde o cérebro e prejudica o córtex pré-frontal. Prejudicada, esta área para de funcionar, o indivíduo perde a noção de tempo e esquece de realizar atividades que são prioridades para sua saúde, por exemplo se alimentar, tomar banho, socializar, entre outros. Sendo assim, vários transtornos contemporâneos estão sendo desencadeados e, por este motivo, diversos estudos estão sendo realizados para verificar e auxiliar a compreensão, a prevenção e o funcionamento dessas possíveis psicopatologias.
Intervenções direcionadas para crianças em vulnerabilidade social
Authors: Duarte Antão Sandra , De Azevedo Peixoto Ana Cláudia
Published: August 2021

Crianças em vulnerabilidade social estão expostas a inúmeros estressores que ocorrem de maneira crônica, contribuindo para alterações importantes nas habilidades de autorregulação e socioemocionais. O trabalho direcionado para essa fase do desenvolvimento tem sido apontado como um fator de proteção importante na prevenção de psicopatolgoias ao longo da vida. O objetivo deste artigo foi mapear quais intervenções, a partir dos pressupostos teóricos da abordagem Cognitivo Comportamental, têm sido aplicadas no Brasil na última década para crianças e famílias em situação de vulnerabilidade social. Para tal, foi utilizado o método da Revisão Integrativa da Literatura. A escolha desta abordagem psicológica justificou-se por ter vasta comprovação empírica e resultados científicos eficazes e eficientes. Após o estudo não foram encontrados protocolos baseados nesta abordagem teórica para esta finalidade, o estudo apontou ainda que para atuação em contextos de vulnerabilidade social é necessário o trabalho em rede e que o pesquisador participe ativamente do contexto ecológico da comunidade. Tornam-se relevantes pesquisas que contribuam para que a Terapia Cognitivo Comportamental tenha resultados que abarquem populações que vivenciam situações de vulnerabilidade social, favorecendo o acesso de crianças e suas famílias a técnicas que poderão emergir como um importante componente de prevenção, podendo indicar diálogos que visem diferentes formas de redução da desigualdade social no país.
Molecular Effects of Pteryxin and Scopoletin in the 5xFAD
Alzheimer’s Disease Mouse Model
Authors: Kiris Irem , Skalicka-Wozniak Krystyna , Basar Merve Karayel , Sahin Betul , Gurel Busra , Baykal Ahmet Tarik
Published: August 2021

Background:

Alzheimer’s disease (AD) is one of the most prevalent diseases
with rapidly increasing numbers, but there is still no medication to treat or stop the disease.
Previous data on coumarins suggests that scopoletin may have potential benefits in
AD.

Objective:

Evaluate the therapeutic potential of the coumarins with natural origin - scopoletin
and pteryxin- in a 5xFAD mouse model of AD

Methods:

Both compounds were administered at two doses to 12-month-old mice, which
represent severe AD pathology. The effects of coumarins were assessed on cognition in
mouse experiments. Changes in the overall brain proteome were evaluated using LCMS/
MS analyses.

Results:

The Morris water maze test implicated that a higher dose of pteryxin (16 mg/kg)
significantly improved learning, and the proteome analysis showed pronounced changes
of specific proteins upon pteryxin administration. The amyloid-β precursor protein, glial
fibrillary acid protein, and apolipoprotein E protein which are highly associated with AD,
were among the differentially expressed proteins at the higher dose of the pteryxin.

Conclusion:

Overall, pteryxin may be evaluated further as a disease-modifying agent in
AD pathology in the late stages of AD.
Explore the Active Ingredients and Mechanisms in Musa basjoo
Pseudostem Juice against Diabetes Based on Animal Experiment, Gas
Chromatography-mass Spectrometer and Network Pharmacology
Authors: Xu Feng , Wu Hongmei , Wang Xiangpei , Wei Xiujuan , Chen Teng
Published: August 2021

Background:

Musa basjoo pseudostem juice (MBSJ) is a well-known Chinese
medicine, and Miao people use MBSJ to treat diabetes. In this work, the active ingredients and
molecular mechanism of MBSJ against diabetes were explored.

Methods:

Anti-diabetic activity of MBSJ was evaluated using diabetic rats, and then the
ingredients in the small-polar parts of MBSJ were analyzed by gas chromatography-mass
spectrometer (GC-MS). Targets were obtained from several databases to develop the "ingredienttarget-
disease" network by Cytoscape. A collaborative analysis was carried out using the tools in
Cytoscape and R packages, and molecular docking was also performed.

Results:

MBSJ improved the oral glucose tolerance and insulin tolerance, and reduced fasting
blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, and low-density lipoprotein
levels in the serum of diabetic rats. 13 potential compounds were identified by GC-MS for
subsequent analysis, including Dibutyl phthalate, Oleamide, Stigmasterol, Stigmast-4-en-3-one,
etc. The anti-diabetic effect of MBSJ was related to multiple signaling pathways, including
Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Endocrine resistance,
Rap1 signaling pathway, EGFR tyrosine kinase inhibitor resistance, etc. Molecular docking at least
partially verified the screening results of network pharmacology.

Conclusion:

MBSJ had good anti-diabetic activity. The small-polar parts of MBSJ were rich in
anti-diabetic active ingredients. Furthermore, the analysis results showed that the anti-diabetic
effect of the small-polar parts of MBSJ may be the result of multiple components, multiple targets,
and multiple pathways. The current research results can provide important support for studying the
active ingredients and exploring the underlying mechanism of MBSJ against diabetes.
Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat
Model: A First Report
Authors: Borah Sudarshana , Sarkar Priyanka , Sharma Hemanta Kumar
Published: August 2021

Background:

Dementia correlates with Alzheimer’s disease, Parkinson’s disease, frontotemporal
and cerebrovascular diseases. There are supporting shreds of evidence on the pharmacological
activity of curcuma caesia (Zingiberaceae family) for its antioxidant, antidepressant, analgesic,
anticonvulsant, and anti-acetylcholinesterase effect.

Objective:

This study aims to analyze the fecal microbial profile in Zederone treated demented rat
model.

Method:

In our study, isolation and characterization of Zederone were carried out from curcuma
caesia rhizomes, followed by estimation of its memory-enhancing effect on Aluminium-induced demented
rat, which was evaluated by behavioural study on radial 8 arm maze. Moreover the detection
of amyloid plaque formation was carried out using fluorescent microscopy of the congo red-stained
rat brain tissues of the cerebral neocortex region. This study included eighteen female Wistar
Albino rats that were divided into three groups that consisted of six rats in each group. The
study of fecal microbial profile by metagenomic DNA extraction followed by next-generation sequencing
was carried out to establish the correlation between gut microbes and amyloid plaques in
dementia.

Results:

Zederone could be characterized as pale yellow colored, needle-shaped crystals with
96.57% purity. This compound at 10 mg/kg body weight showed cognition improving capacity (p
≤ 0.0001) with a reduction of accumulated amyloid plaques that were detected in the demented
group in fluorescence microscope and fecal microbiome study divulged an increased shift towards
Lactobacillus genera in the treated group from Bacteroides in the demented group.

Conclusion:

This sesquiterpenoid compound would assist in the modulation of gut bacterial dysbiosis
and act as a better therapeutic drug for dementia and other neurological disorders.
EFFECTS OF AGMATINE ON ACOUSTIC STARTLE REFLEX AND AUDITORY SYSTEM IN RATS
Authors: Saatci Özlem , Çevreli Burcu , Uzbay Tayfun
Published: August 2021

Background: A polyamine, agmatine, has been proposed as a new neurotransmitter in the brain. Objective: The aim of this study was to evaluate the effects of acute and chronic agmatine treatment on the rat auditory system. Methods: Male Wistar albino rats weighing between 280-330 grams were used. Animals were divided into four groups (n= 8 for each group). Acute and chronic agmatine (160 mg/kg) was administered to rats. Prepulse inhibition (PPI) of the acoustic startle reflex (ASR), distortion product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABR) were evaluated in all groups. Results: Both acute and chronic agmatine treatments also significantly disrupted PPI. Chronic but not acute treatment with agmatine produced some DPOAE and ABR changes in rats. Conclusion: Our results suggested that chronic agmatine treatment for seven days resulted in some significant negative changes in cochlear function. Because the PPI of the ASR is also used as an indicator for psychoses, such as schizophrenia, in human and experimental animal studies, our findings also imply that the DPOAE and ABR tests may also be considered in the diagnosis and follow-up of patients with psychoses.
CASE REPORT OF IDIOPATHIC BILATERAL ORBITAL MYOSITIS
Authors: Şimşek Fatma
Published: August 2021

Orbital myositis is an inflammatory disease affecting extraocular muscles. Mostly unilateral and rarely bilateral orbital involvement is seen. Bilateral involvement is a secondary table to systemic diseases and recurrence can be seen. Diagnosis is made by clinical, examination and imaging. Increased density of extraocular muscles and increased muscle mass should be seen in computed tomography or magnetic resonance imaging. The basis of the diagnosis is exclusion and the differential diagnosis needs to be done well. Steroids and other immunosuppressive agents may be used in the treatment. Patients respond dramatically to steroid treatment. While short-term steroid treatment may be sufficient in idiopathic patients, orbital myositis secondary to systemic disease requires longer-term and non-steroid immunosuppressive treatments. Here, a case of idiopathic orbital myositis with bilateral involvement is presented as it is a rare condition.
ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
Authors: Prayitnaningsih Seskoati , Dwi Oktariana Asrory Virna , Nusanti Synthia , Listyaningsih Erlin , Budi Siswanto Bambang , Santoso Anwar
Published: August 2021

Background: Normal-Tension_Glaucoma (NTG) is an eye disease and characterize with low intraocular pressure (IOP) levels. In population-based settings, the diagnose of glaucoma is based on the IOP levels of 21 mmHg, and its usually delayed. A recent study HbA1c levels could lead to IOP changes. Obstructive Sleep Apnea (OSA) result oxidative stress that results an altered function of neutrophil in patients with NTG. Objective: To_evaluate the association of HbA1c, Netrophil-to-Lymphocyte Ratio_(NLR) toward NTG as its novel early detection. Methods: This study divided into two groups consisted of Metabolic Syndrome ( MS) + OSA without eye disorder as control (15 subjects) and MS + OSA + NTG patients (14 subjects). IDF criteria was used to established MS, and risk of OSA determined by STOP-BANG Questionnaire. The diagnosis of NTG was confirmed by normal IOP measured by Tonopen. Mean Defect (MD) of visual field evaluated by Automated Humphrey Perimetry, Retinal Nerve Fiber Layer (RNFL) established by OCT. HbA1c measured by ELISA and NLR by flowcytometry. Statistical analysis consisted of comparison and correlation test Results: The ratio of CD was significantly higher in NTG patients (0.54 ± 0.13) compared to control (0.26 ± 0.07; p<0.001). MD was also higher in subjects with NTG (6.80 ± 3.90) compared to control (4.97 ± 2.28; p=0.134). Mean RNFL was lower in subjects with NTG (87.95 ± 28.29) compared to control (95.07 ± 26.66; p=0.035). Positive correlation between HbA1C-MD (r = 0.456, p = 0.013) and NLR-RNFL thinning (r = 0.525, p = 0.003) was existed in Metabolic Syndrome (MS) patients. Conclusion: Patients with MS and OSA risk have an increased risk of NTG. A novel association between Hba1C levels, NLR and NTG was also identiﬁed.
SERUM MYELOPEROXIDASE, MALONDIALDEHYDE, ALPHA-SYNUCLEIN LEVELS IN PATIENTS WITH EPILEPSY
Authors: Şimşek Fatma , Ceylan Mustafa , Aşkın Seda , Kızıltunç Ahmet
Published: August 2021

Background: Processes such as neurodegeneration, hypoxia, blood brain barrier dysfunction and oxidative changes are effective for epileptogenesis.There is no non-invasive biomarker that can be used in the follow-up of patients with epilepsy, which is a neurodegenerative disease. Objective: In our study, it was aimed to investigate the relationship between inflammatory, oxidative, neurodegenerative processes, and antiepileptic use in patients with epilepsy. Methods: The groups were formed from the patients who were followed up in the epilepsy outpatient clinic between April 2019-June 2019, and the age-gender-matched control group.The study included 30 patients and 30 healthy volunteers. Venous serum samples were collected from groups to study myeloperoxidase, malondialdehyde and alpha-synuclein. Results: The levels of myeloperoxidase and malondialdehyde were higher in the control group and this difference was statistically significant (p=0.003, p<0.001). The level of α-syn was higher in the epilepsy group and there was no statistically significant difference between the two groups (p=0.52). There was a positive correlation between the α-syn level and disease duration and as the disease duration increased, the level of α-syn increased (r=0.379, p=0.03). Conclusion: Although the α-syn level increases with the duration of the disease in epilepsy patients, it is not a suitable parameter for use as a biomarker in the follow-up.
COGNITIVE IMPAIRMENT IN HYPERTENSIVES
Authors: Tipnis Natasha , Rajadhyaksha Girish , Shah Meghav
Published: August 2021

Background: Hypertension and dementia increase parallel to age. Objective: The purpose of this study was to study the effect of hypertension on cognition before age-related cognitive impairment begins to set in. Methods: In this prospective, cross-sectional study conducted at a tertiary-care centre between May 2014 and December 2015, 300 (150 hypertensives and 150 normotensives) participants were compared. Patients were divided into groups according to age, gender, education, and duration of hypertension. The Hindi Mini-Mental State Examination (HMMSE) was used to detect cognitive impairment. Results: Overall, occurrence of cognitive impairment was 53 (35.3%) in hypertensives and 37 (24.7%) in normotensives. Below 60 years male and female hypertensives and normotensives had comparable mean HMMSE scores, although not statistically significant. Sixty years and above male and female normotensives achieved slightly higher HMMSE scores than male and female hypertensives, however this finding was statistically significant (p=0.002) for males ≥60 years. Among the cognitive domains, orientation to time (p=0.009), registration (p=0.018), recall (p=0.031), and 3 step command (p=0.014) were statistically different between hypertensives and normotensives. Periventricular white matter ischemia was discovered in 8 (5.3%) and 2 (1.3%) hypertensives and normotensives, respectively. Conclusion: Although hypertension was not statistically associated with cognitive decline in hypertensives <60 years, hypertensives >60 years showed statistical significance with cognitive decline. Furthermore, specific cognitive domains such as orientation to time, registration, recall, and 3 step command displayed statistical significance for cognitive decline. Future prospective, large-scale studies are warranted to investigate these and other possible associations.
Relationship Between Perceived Risks of Using mHealth Applications and the Intention to Use Them Among Older Adults in the Netherlands: Cross-sectional Study
Authors: Klaver Nicky Sabine , van de Klundert Joris , van den Broek Roy Johannes Gerardus Maria , Askari Marjan
Published: August 2021

Background

Considering the increasing demand for health services by older people and the ongoing COVID-19 pandemic, digital health is commonly viewed to offer a pathway to provide safe and affordable health services for older adults, thus enabling self-management of their health while health care systems are struggling. However, several factors cause older people to be particularly reluctant to adopt digital health technologies such as mobile health (mHealth) tools. In addition to previously studied technology acceptance factors, those related to perceived risks of mHealth use (eg, leakage of sensitive information or receiving incorrect health recommendations) may further diminish mHealth adoption by older adults.

Objective

The aim of this study was to explore the relationship between perceived risks of using mHealth applications and the intention to use these applications among older adults.

Methods

We designed a cross-sectional study wherein a questionnaire was used to collect data from participants aged 65 years and older in the Netherlands. Perceived risk was divided into four constructs: privacy risk, performance risk, legal concern, and trust. Linear regression analyses were performed to determine the associations between these perceived risk constructs and the intention to use mHealth applications.

Results

Linear regression per perceived risk factor showed that each of the four constructs is significantly associated with the intention to use mobile medical applications among older adults (adjusted for age, sex, education, and health status). Performance risk (β=–.266; P=<.001), legal concern (β=–.125; P=.007), and privacy risk (β=–.100; P=.03) were found to be negatively correlated to intention to use mHealth applications, whereas trust (β=.352; P=<.001) was found to be positively correlated to the intention to use mHealth applications.

Conclusions

Performance risk, legal concern, and privacy risk as perceived by older adults may substantially and significantly decrease their intention to use mHealth applications. Trust may significantly and positively affect this intention. Health care professionals, designers of mHealth applications, and policy makers can use these findings to diminish performance risks, and tailor campaigns and applications to address legal and privacy concerns and promote mHealth uptake and health care access for older adults, especially during the COVID-19 pandemic.
Genetic variants and susceptibility to severe COVID-19: a scoping review protocol (Preprint)
Authors: Candelo Estephania , Gutiérrez-Medina Juan David , Gempeler Andrés , Diaz-Ordoñez Lorena , Pachajoa Harry
Published: August 2021

BACKGROUND

Coronavirus disease 19 (COVID-19), the disease caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is already responsible for more than four and a half million deaths worldwide. With a unique pathophysiology related to respiratory failure due to interstitial pneumonia and acute respiratory distress syndrome, severe COVID-19 is qualitatively different from moderate disease. Since genetics play a crucial role in susceptibility to viral infection and propensity to develop harmful inflammatory conditions, genetic heterogeneity promotes the question of whether gene variants might influence COVID-19 outcomes. The identification of genetic variants associated with severe courses of COVID-19 is a promising option for the improvement of prognostic tools, contemplation of new therapeutic targets and the development of patient’s clinical risk stratification.

OBJECTIVE

We aim to perform a scoping review to assess the extent of the literature regarding the gene variants that could be associated with COVID-19 severity.

METHODS

The proposed scoping review will be conducted in accordance with the methodology from the Joanna Briggs Institute’s Scoping Review Network.12 The search strategy will focus on published studies without discriminating in date or language. A multiple-database search (MEDLINE, LILACS, The Cochrane Library, Science Direct, Google Scholar and OpenGrey) will be done performing the following strategy: ((("COVID-19"[Mesh] OR "SARS-CoV-2"[Mesh]) AND ("Polymorphism, Genetic"[Mesh] OR "Mutation"[Mesh] OR "Antibody Diversity"[Mesh] OR "Antigenic Variation"[Mesh]) AND ("Severity of Illness Index"[Mesh] OR "Death"[Mesh] OR "Critical Care"[Mesh] OR "Critical Illness"[Mesh] OR (severity))). This scoping review will consider observational studies and genome-wide association studies (GWAS) without discriminating in date or language. Additionally, systematic reviews that meet the inclusion criteria will also be considered. Data will be extracted from papers included in the scoping review by two independent reviewers using an already existent data extraction tool.

RESULTS

The conducted search was performed on February 16th in MEDLINE, LILACS, The Cochrane Library, Science Direct, Google Scholar and OpenGrey retrieved a total of 2190 results. Completion of the review is expected in late 2021.

CONCLUSIONS

This scoping review will be the first to map the extent of information regarding the genetic variants associated to the severity of COVID-19. The data gathered by this investigation could lead to biomarkers of severity in COVID-19 and the stratification of patients according to their genetic risk of disease severity.
An Experimental Study of Tribological Behavior of Journal Bearing Material under Powder and Granular Lubrication
Authors: Haral Ashwini
Published: August 2021

Abstract: Proper lubrication of mechanical components is very important for the reliable efficiency and useful life. The working temperature of the components can affect the lubricating oil and can degrade the lubricating characteristics of oil. This paper presents the experimental investigation on tribological behaviour of journal bearing material. Two types of additives are used in lubricating oili.e., powder and granular types of additives. The investigation is carried out on pin-on-disc apparatus to determine the wear and coefficient of friction. The statistical analysis is performed using design of experiments and Taguchi robust design to determine the optimum parameters of lubricating additives. It is found that for constant speed of 400 rpm with 5% concentration with varying size the granular lubrication have lower values than powder lubrication for all load conditions Keywords: Lubrication, pin-on-disc, Taguchi, additives.
A Study on Implementation of Low Impact Development as an Urban Stormwater Management Technique in Srinagar City: Current Trends, Issues and Challenges
Authors: Bilal Basrah
Published: August 2021

Abstract: The Severity as well as the frequency of short-duration, but damaging, urban area floods have increased in recent years across the world. Alteration to the urban micro-climate due to global climate change impacts may also exacerbate the situation in the near future. The events of floods have increased in Srinagar city as well over the past decades. Sustainable urban stormwater management using low impact development (LID) techniques, along with conventional urban stormwater management systems, can be implemented to mitigate climate-change-induced flood impacts in Srinagar. In this study, the supposed effectiveness of LIDs in the mitigation of urban flood in Srinagar city is analysed keeping in view their limitations at the same time. A critical research on the success of these techniques in urban flood mitigation planning in Srinagar city is also recommended. On summarising different LID approaches in the world, the results revealed that LIDs can be an efficient method for mitigating urban flood impacts. Most of the LID devices developed so far, however, are found to be effective only for small flood peaks. The major challenges include identification of the best LID practices for the region of interest, efficiency improvements in technical areas, and site-specific optimization of LID parameters. Research and improvements in these areas will allow better mitigation of climate-change-induced urban floods in a cost-effective manner and will also assist in the achievement of sustainable development goals for Srinagar city and will help us to tackle the increasing problems of water logging and floods in the summer capital of Jammu and Kashmir. Keywords: Climate change, Urban floods, stormwater management, Low Impact Development, Srinagar city, Drainage in Srinagar, Pluvial flooding.
Avaliação biofarmacêutica de dipirona comprimido pós-comercialização: medicamentos de referência, genéricos e similares
Authors:   Núcleo de Pesquisa e Análise de Medicamentos (NuPAM), Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil, Silva dos Santos Eliane , dos Santos Teles Cardoso Amanda ,   Núcleo de Pesquisa e Análise de Medicamentos (NuPAM), Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil / Programa de Pós-graduação em Farmácia, Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil, Cristina Laignier Cazedey Edith ,   Núcleo de Pesquisa e Análise de Medicamentos (NuPAM), Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil / Programa de Pós-graduação em Farmácia, Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil
Published: August 2021

Introdução: A dipirona é um potente analgésico e antipirético inscrito na Relação Nacional de Medicamentos Essenciais. Ademais é estrategicamente indicada em casos especiais, como no tratamento paliativo de: dengue, chikungunya, zika e COVID-19. Problemas pós-comercialização, como não conformidades na qualidade, vêm sendo apontados para medicamentos contendo dipirona, resultando em recolhimentos frequentes pela Agência Nacional de Vigilância Sanitária. Objetivo: Averiguar a qualidade e a equivalência farmacêutica dos comprimidos de dipirona, referência, genéricos e similares, disponíveis comercialmente para a população da cidade de Salvador/BA. Método: Estudo experimental utilizando metodologias descritas na monografia da dipirona sódica comprimidos da Farmacopeia Brasileira 6ª edição. Foram analisadas três diferentes marcas de genérico, dois similares e o referência, coletadas no comércio da cidade de Salvador-Bahia. Adicionalmente, foi desenvolvido um método analítico alternativo por espectrofotometria na região ultravioleta para a análise da dipirona sódica comprimidos, validado com base na RDC n° 166, de 24 de julho de 2017. Resultados: Os comprimidos de dipirona sódica referência, genéricos e similares atenderam aos requisitos quanto aos testes de identificação e características. Uma amostra de medicamento similar não atendeu ao teste de dissolução e somente duas amostras, dos medicamentos genéricos, foram satisfatórias para a intercambialidade. O método farmacopeico para doseamento da dipirona sódica comprimidos demonstrou problemas relacionados à subjetividade do analista e a incerteza do método. O método alternativo proposto mostrou-se seletivo, linear, preciso, exato e robusto, indicado para a quantificação da dipirona em comprimidos. Conclusões: O monitoramento pós-comercialização de medicamentos com elevado padrão de consumo pela população, como a dipirona, pode sinalizar questões a serem investigadas pela vigilância sanitária, com o objetivo de apoiar sua missão de proteção à saúde da população.
[ID 53971] IMPACTO DAS CONDIÇÕES SOCIOECONÔMICAS NO DESENVOLVIMENTO NEUROMOTOR DE CRIANÇAS DE 3 A 12 MESES
Authors: Miranda do Nascimento Julia , Fonseca de Queiroz Marcelino Juliana , Chagas Almeida Bruna , Mendonça de Miranda Rita de Cássia , Costa Albuquerque Raquel
Published: August 2021

Objetivo: Identificar a relação entre as condições socioeconômicas e o desenvolvimento neuromotor de crianças de 3 a 12 meses. Metodologia: Realizou-se um estudo observacional descritivo com crianças de 3 a 12 meses em uma Unidade de Saúde da Família, Recife-PE. Foram avaliadas 17 crianças e suas famílias, por meio do instrumento Harris Infant Neuromotor Test com o público infantil e um questionário socioeconômico, aplicado com os cuidadores. O resultado do instrumento de avaliação foi obtido em escore, classificados em anormal, suspeito, dentro dos limites normais e avançado. A análise dos dados ocorreu por meio de dois testes estatísticos. O primeiro, Kruskall Wallis, verificou o grau de significância das variáveis do questionário e, posteriormente, o resultado foi gerado no teste ANOVA two way, a fim de correlacionar os itens significativos com todos os escores do instrumento de avaliação. Resultados: Os resultados apontaram que as variáveis: escolaridade, renda familiar e quantidade de pessoas na casa influenciavam os escores obtidos pelas crianças, na avaliação do desenvolvimento, seja de maneira positiva ou negativa. Conclusões: O estudo mostrou a relevância de avaliar o desenvolvimento infantil, bem como os fatores socioeconômicos que o influenciam. Isso permite que os profissionais da área, como o terapeuta ocupacional, identifiquem questões sociais que podem interferir no ganho das habilidades infantis pertinentes de cada faixa etária.
[ID 55356] ANÁLISE DE MICRONÚCLEO COMO INDICADOR DE GENOTOXICIDADE EM PACIENTES COM DOENÇA PULMONAR OBSTRUTIVA CRÔNICA SUBMETIDOS À REABILITAÇÃO PULMONAR
Authors: Da Silva Andrade Cleidiane , Rafael Almeida Moraes William , Figueiredo Monteiro Luiz Humberto , Haru Sawaki de Melo e Silva Simone , Castro da Silva Pedro Iuri , De Oliveira Chaves Leonardo , Marques Ferreira Normando Valéria
Published: August 2021

Objetivo: Analisar a frequência de micronúcleos em células da mucosa oral de pacientes com doença pulmonar obstrutiva crônica (DPOC), submetidos a um programa de reabilitação pulmonar (PRP). Metodologia: Estudo quase experimental, quantitativo, prospectivo, não controlado, no qual sete participantes com diagnóstico clínico e espirométrico de DPOC, foram submetidos a 20 sessões de um PRP, realizado em 7 semanas contínuas. Para classificar o estágio da doença, realizou-se o exame de espirometria antes de iniciar o protocolo. Para a quantificação de micronúcleos, antes e após o PRP foi realizado o teste de micronúcleo na mucosa oral. Para analisar os dados coletados, aplicou-se o teste de Shapiro Wilk para verificar a normalidade das variáveis e o teste Wilcoxon para comparação antes e depois, adotando-se um nível de significância p≤0,05. Resultados: Observou-se redução significativa (p=0,043) na frequência de micronúcleos em células epiteliais da mucosa oral após a aplicação do PRP. Conclusão: A diminuição da frequência de micronúcleos no pós-tratamento permite sugerir que os participantes obtiveram diminuição dos danos no DNA quando submetidos ao PRP, no entanto, ensaios controlados e randomizados devem ser realizados para elucidar os efeitos do treinamento físico sobre o caráter genético de pacientes com DPOC.
“Com amor às terras que habitam”
Authors: Morais Ana Lunara da Silva
Published: August 2021

Este artigo tem por objetivo analisar a imposição de uma mentalidade proprietária familiar aos indígenas, operada por meio das obrigações do Diretório dos Índios (1758). Esse determinou que as terras comunais indígenas, as quais foram frequentemente usurpadas por colonizadores, fossem divididas em lotes, isto é, como residências familiares individuais. Ao longo desta pesquisa verificou-se que os índios da missão de Guajiru, capitania do Rio Grande do Norte, tiveram, desde a década de vinte do Setecentos, parte de suas terras apropriadas por membros da família Carneiro da Cunha, não lhes sendo restituídas mesmo após o conhecimento de sua usurpação mediante as averiguações realizadas para a implementação do Diretório dos Índios. Constatou-se que os índios de Guajiru apenas receberam terras de qualidade inferior, vizinhas ao antigo aldeamento, para, segundo as autoridades responsáveis, fomentar o projeto colonial do Diretório. Dessa forma, a pesquisa evidencia que os índios de Guajiru, além de terem parte de suas terras tomadas, sofreram, através da divisão de sua terra em pequenas propriedades, uma intensa mudança na cultura indígena no que diz respeito à sua relação com a terra. Para tanto, nesta pesquisa, inserida no campo da história social da propriedade, realizou-se o cruzamento e análise de diversas fontes, como cartas e requerimentos, de variados arquivos, especialmente do Arquivo Histórico Ultramarino, do Instituto Histórico e Geográfico Brasileiro, dos Anais da Biblioteca Nacional do Rio de Janeiro e do Arquivo Público do Estado de Pernambuco. Esta pesquisa apresenta resultados parciais de uma investigação realizada para uma dissertação de mestrado.
democracia dos desempregados
Authors: Rocha Junior Geovanni
Published: August 2021

Durante a década de 1990, o Brasil passou por profundas transformações nas relações de trabalho, que podem ser observadas por meio da crescente taxa de desemprego e do númerode trabalhadores alocados na informalidade. Neste artigo, pretende-se analisar as narrativas que circularam no jornal Diário Catarinenseacerca de aspectos que dizem respeito à elaboração de novas formas de abordar a temática do trabalho no espaço público,bem como a defesa de um conjunto de valores associados à livre iniciativa, que ganhou notoriedade com os governos de Fernando Collor e Fernando Henrique Cardoso. A linha editorial do jornal defendeu a integração do país ao chamado “Primeiro Mundo”, alegando que havia a necessidade de alçar o país aos ditames de uma modernidade própria do final do século XX. As notícias difundidas nas páginas do periódico, sobretudo na seção dedicada aos assuntos do cotidiano, deixam latente a formação de representações sociais sobre o futuro do trabalho, que ficaria restrito ao aperfeiçoamento profissional devido ao avanço tecnológico e a um arcabouço jurídico menos rígido como forma de combate ao desemprego. Este artigo está inserido na lógica da História do Tempo Presenteà medida que tenta colocar em prática os referenciais teóricos e metodológicos desse domínio do campo da produção histórica.
The impact of corporate social responsibility on consumer’s relationship intention: Evidence from MENA countries
Authors: AlHares Aws , Abu-Asi Tarek , Dominic Gerard , Al Abed Ruba
Published: August 2021

Corporate social responsibility (CSR) raised the attention of the MENA market, given its capacity to influence consumers’ purchase intention and, particularly, consumers’ repurchase intention. Therefore, CSR helps to build a long-term relationship between the companies with its consumers. Following this new trend, our work contributes to the understanding of how CSR contributes to a long-term relationship with consumers. To achieve that, we considered the four dimensions of CSR (philanthropic, legal, organisation, and ethics) and used those constructs to evaluate the consumers’ relationship intention with companies. Our research was performed in MENA countries by interviewing 1632 consumers. Our findings showed that the philanthropic, legal, and ethical dimensions played a relevant role in determining a long-term relationship between the companies and consumers. This research results differ from the results gained by other researchers in previous studies. Therefore, to establish a long-term relationship with consumers, MENA countries’ companies should focus on philanthropy, legal, and ethics. This study extends, as well as contributes to the extant corporate social responsibility literature by offering new evidence on the impact of corporate social responsibility on consumer relationship intention. The findings will help regulators and policy-makers in evaluating the adequacy of the current corporate social responsibility reforms to prevent management misconduct and scandals.
Factores relacionados con osteoartritis en trabajadores informales del centro de Medellín, Colombia
Authors: Garzón Duque María Osley , Marín Franco Mariana , Orrego Vélez María Antonia , Villegas Wills Martina , Rodríguez Ospina Fabio León , Cardona Arango María Dorys , Segura Cardona Ángela María , Villa Parra Verónica
Published: August 2021

Introducción: Se hace una correlación entre la osteoatrosis y  las condiciones laborales, hábitos y estilos de vida de los trabajadores informales del centro de Medellín, Colombia.
Objetivo: Identificar la relación de la osteoartritis y la prevalencia de enfermedades crónicas y degenerativas con las condiciones sociodemográficas, laborales, hábitos y estilos de vida en un grupo de trabajadores informales de Medellín, Colombia.
Materiales y métodos: Estudio transversal, con fuente primaria de información  de 686 trabajadores informales.  Se realizó una encuesta asistida, previa toma de consentimiento. Se seleccionaron  289 trabajadores con diagnóstico de enfermedad crónica o degenerativa, ≥18 años, con ≥5 años en su oficio. Se realizaron análisis exploratorios y de asociación con prueba Chi2, y cálculo de RP con IC del 95%.
Resultados: el 79,9% de la población padecía alguna enfermedad crónica. El 3,46% presentaba diagnóstico de osteoartritis, siendo significativamente mayor (p<0,05) en quienes tenían entre 21 y 30 años en su oficio (RP=5,62. IC:1,20;26,34). También fue mayor la prevalencia de osteoartritis en; >45 años (RP=2,26), mujeres (RP:4,44), trabajadores sedentarios (RP=1,71), obesos (RP=3,40), así como en quienes habían sido obreros (RP=1,30), en aquellos que tenían puestos de venta semiestacionaria (RP=2,21), vendían productos de cosecha y perecederos (RP=1,78), en quienes trabajaban >8 horas diarias (RP:2,77),  ≤5días a la semana (RP=3,10), no tenían espacio suficiente para moverse (RP=2,08), y en quienes tenían posturas o movimientos forzados (RP=2,72). Conclusión: En la población de vendedores informales del centro de Medellín, los factores sociodemográficos, laborales, hábitos y estilos de vida modificables se relacionan con una  mayor prevalencia de osteoartritis.
Resilience of tourism employees to changes caused by COVID-19 pandemic
Authors: Bozovic Tamara , Blesic Ivana , Nedeljkovic-Knezevic Milena , Djeri Lukrecija , Pivac Tatjana
Published: August 2021

Although tourism is an industry that has become resistant to various problems
over time, the consequences left by COVID?19 pandemic have taken on global
proportions. Serbia, like many other countries, has suffered a great damage
in tourism industry since the beginning of the pandemic. However, research
on the connection between COVID?19 and tourism in Serbia is in its infancy.
As no research has been conducted in Serbia on the resilience of employees
in different sectors of tourism, the main goal of this study is to determine
the extent to which employees in tourism sectors in Serbia are resilient to
changes caused by COVID?19 pandemic. Also, the study aimed to determine the
intentions in the behavior of employees after the pandemic. Respondents who
participated in the research are employed in various sectors of tourism
(travel agencies, travel organizations, tourist guides, employees in the
hospitality industry, and academic sector). To achieve goals, the survey was
conducted among 264 participants in November and December 2020. A scale of
50 statements was applied, and by applying the Exploratory Factor Analysis
(EFA), three resilience factors (competence, communication, and
self?efficiency) were singled out. The results of the research show that
employees in tourism are largely resilient to the changes, and the strongest
factor that stands out among the respondents is competence. In addition,
study proved that all the factors of the resilience are expected to have a
positive effect on the behavior of employees in the post?crisis period.