bluuebunny/crossref_metadata_2025 huggingface dataset:
Fibroblast Diversity and Epigenetic Regulation in Cardiac Fibrosis
Authors: Aguado-Alvaro Laura Pilar , Garitano Nerea , Pelacho Beatriz
Published: May 2024

Cardiac fibrosis, a process characterized by excessive extracellular matrix (ECM) deposition, is a common pathological consequence of many cardiovascular diseases (CVDs) normally resulting in organ failure and death. Cardiac fibroblasts (CFs) play an essential role in deleterious cardiac remodeling and dysfunction. In response to injury, quiescent CFs become activated and adopt a collagen-secreting phenotype highly contributing to cardiac fibrosis. In recent years, studies have been focused on the exploration of molecular and cellular mechanisms implicated in the activation process of CFs, which allow the development of novel therapeutic approaches for the treatment of cardiac fibrosis. Transcriptomic analyses using single-cell RNA sequencing (RNA-seq) have helped to elucidate the high cellular diversity and complex intercellular communication networks that CFs establish in the mammalian heart. Furthermore, a significant body of work supports the critical role of epigenetic regulation on the expression of genes involved in the pathogenesis of cardiac fibrosis. The study of epigenetic mechanisms, including DNA methylation, histone modification, and chromatin remodeling, has provided more insights into CF activation and fibrotic processes. Targeting epigenetic regulators, especially DNA methyltransferases (DNMT), histone acetylases (HAT), or histone deacetylases (HDAC), has emerged as a promising approach for the development of novel anti-fibrotic therapies. This review focuses on recent transcriptomic advances regarding CF diversity and molecular and epigenetic mechanisms that modulate the activation process of CFs and their possible clinical applications for the treatment of cardiac fibrosis.
Current Insights into Sublethal Effects of Pesticides on Insects
Authors: Bartling Merle-Theresa , Brandt Annely , Hollert Henner , Vilcinskas Andreas
Published: May 2024

The effect of pesticides on insects is often discussed in terms of acute and chronic toxicity, but an important and often overlooked aspect is the impact of sublethal doses on insect physiology and behavior. Pesticides can influence various physiological parameters of insects, including the innate immune system, development, and reproduction, through a combination of direct effects on specific exposed tissues and the modification of behaviors that contribute to health and reproductive success. Such behaviors include mobility, feeding, oviposition, navigation, and the ability to detect pheromones. Pesticides also have a profound effect on insect learning and memory. The precise effects depend on many different factors, including the insect species, age, sex, caste, physiological condition, as well as the type and concentration of the active ingredients and the exposure route. More studies are needed to assess the effects of different active ingredients (and combinations thereof) on a wider range of species to understand how sublethal doses of pesticides can contribute to insect decline. This review reflects our current knowledge about sublethal effects of pesticides on insects and advancements in the development of innovative methods to detect them.
A Multimethod Approach for Healthcare Information Sharing Systems: Text Analysis and Empirical Data
Authors: Malhan Amit , Pavur Robert , Pelton Lou E. , Hajian Ava
Published: May 2024

This paper provides empirical evidence using two studies to explain the primary factors facilitating electronic health record (EHR) systems adoption through the lens of the resource advantage theory. We aim to address the following research questions: What are the main organizational antecedents of EHR implementation? What is the role of monitoring in EHR system implementation? What are the current themes and people’s attitudes toward EHR systems? This paper includes two empirical studies. Study 1 presents a research model based on data collected from four different archival datasets. Drawing upon the resource advantage theory, this paper uses archival data from 200 Texas hospitals, thus mitigating potential response bias and enhancing the validity of the findings. Study 2 includes a text analysis of 5154 textual data, sentiment analysis, and topic modeling. Study 1’s findings reveal that joint ventures and ownership are the two main enablers of adopting EHR systems in 200 Texas hospitals. Moreover, the results offer a moderating role of monitoring in strengthening the relationship between joint-venture capability and the implementation of EHR systems. Study 2’s results indicate a positive attitude toward EHR systems. The U.S. was unique in the sample due to its slower adoption of EHR systems than other developed countries. Physician burnout also emerged as a significant concern in the context of EHR adoption. Topic modeling identified three themes: training, healthcare interoperability, and organizational barriers. In a multimethod design, this paper contributes to prior work by offering two new EHR antecedents: hospital ownership and joint-venture capability. Moreover, this paper suggests that the monitoring mechanism moderates the adoption of EHR systems in Texas hospitals. Moreover, this paper contributes to prior EHR works by performing text analysis of textual data to carry out sentiment analysis and topic modeling.
Perceptual Effects of Walnut Volatiles on the Codling Moth
Authors: Li Peixuan , Wei Yang , Chen Guoxiang , Sattar Adil
Published: May 2024

The volatile organic compounds (VOCs) of plant hosts allow insect localization through olfactory recognition. In this study, the oviposition behavior of the codling moth was investigated and the VOCs from different walnut organs were extracted and analyzed to systematically study their composition and content differences. The electrophysiological and behavioral responses of the codling moth to walnut VOCs were measured using gas chromatography–electroantennographic detection (GC-EAD) and a four-arm olfactometer to screen the key active contents. The field investigation results indicated that 90.3% of the eggs spawned by the first generation of adult codling moths were adjacent to the walnut fruits. Walnut VOCs are mainly composed of terpenes, aromatics, and alkanes. Twelve VOCs can produce electroantennogenic (EAG) responses in the codling moths. Both adult males and females exhibit concentration dependence, with notable disparities in their EAG response levels. In the olfactory behavioral bioassay, linalool, eucalyptol, and high doses of geranyl acetate showed repellent effects on the codling moths, while myrcene, β-ocimene, nonanal, methyl salicylate, α-farnesene, and heptaldehyde showed the opposite. The relative levels of heptaldehyde, geranyl acetate, nonanal, and methyl salicylate were high in the fruits, which is intimately related to the localization of the walnut fruit by females. These VOCs can influence the oviposition behavior of codling moths but their application in the control of this pest needs to be confirmed and improved through further field experiments.
Effects of Hypoxia and Inflammation on Hepcidin Concentration in Non-Anaemic COVID-19 Patients
Authors: Gugo Katarina , Tandara Leida , Juricic Gordana , Pavicic Ivelja Mirela , Rumora Lada
Published: May 2024

Background/Objectives: This study aimed to explore the influence of hypoxia, inflammation, and erythropoiesis on hepcidin and other iron status parameters in non-anaemic COVID-19 patients admitted to the emergency unit before the introduction of therapeutic interventions. Methods: Ninety-six COVID-19 patients and 47 healthy subjects were recruited. Patients were subdivided into hypoxic or normoxic groups and, after follow-up, into mild and moderate, severe or critical disease severity groups. Iron, unsaturated iron-binding capacity (UIBC), ferritin, C-reactive protein (CRP), and interleukin 6 (IL-6) were measured on automatic analysers. ELISA kits were used for hepcidin and erythropoietin (EPO) determination. We calculated total iron-binding capacity (TIBC) and ratios of hepcidin with parameters of iron metabolism (ferritin/hepcidin, hepcidin/iron), inflammation (hepcidin/CRP, hepcidin/IL-6), and erythropoietic activity (hepcidin/EPO). Results: Hepcidin, ferritin, EPO, CRP, IL-6, ferritin/hepcidin, and hepcidin/iron were increased, while UIBC, TIBC, hepcidin/CRP, and hepcidin/IL-6 were decreased in hypoxic compared to normoxic patients as well as in patients with severe or critical disease compared to those with mild and moderate COVID-19. Regarding predictive parameters of critical COVID-19 occurrence, in multivariable logistic regression analysis, a combination of EPO and ferritin/hepcidin showed very good diagnostic performances and correctly classified 88% of cases, with an AUC of 0.838 (0.749–0.906). Conclusions: The hypoxic signal in our group of patients was not strong enough to overcome the stimulating effect of inflammation on hepcidin expression. EPO and ferritin/hepcidin might help to identify on-admission COVID-19 patients at risk of developing a critical form of the disease.
CAR-T-Cell-Based Cancer Immunotherapies: Potentials, Limitations, and Future Prospects
Authors: Choudhery Mahmood S. , Arif Taqdees , Mahmood Ruhma , Harris David T.
Published: May 2024

Cancer encompasses various elements occurring at the cellular and genetic levels, necessitating an immunotherapy capable of efficiently addressing both aspects. T cells can combat cancer cells by specifically recognizing antigens on them. This innate capability of T cells has been used to develop cellular immunotherapies, but most of them can only target antigens through major histocompatibility complexes (MHCs). New gene-editing techniques such as clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (CRISPR-cas9) can precisely edit the DNA sequences. CRISPR-cas9 has made it possible to generate genetically engineered chimeric antigen receptors (CARs) that can overcome the problems associated with old immunotherapies. In chimeric antigen receptor T (CAR-T) cell therapy, the patient’s T cells are isolated and genetically modified to exhibit synthetic CAR(s). CAR-T cell treatment has shown remarkably positive clinical outcomes in cancers of various types. Nevertheless, there are various challenges that reduce CAR-T effectiveness in solid tumors. It is required to address these challenges in order to make CAR-T cell therapy a better and safer option. Combining CAR-T treatment with other immunotherapies that target multiple antigens has shown positive outcomes. Moreover, recently generated Boolean logic-gated advanced CARs along with artificial intelligence has expanded its potential to treat solid tumors in addition to blood cancers. This review aims to describe the structure, types, and various methods used to develop CAR-T cells. The clinical applications of CAR-T cells in hematological malignancies and solid tumours have been described in detail. In addition, this discussion has addressed the limitations associated with CAR-T cells, explored potential strategies to mitigate CAR-T-related toxicities, and delved into future perspectives.
A New Approach to the Assessment of Erectile Dysfunction Based on Vasomotion Monitored by the Flow-Mediated Skin Fluorescence (FMSF) Technique—A Preliminary Study
Authors: Slowikowska-Hilczer Jolanta , Walczak-Jedrzejowska Renata , Adamczewska Daria , Byczkiewicz Piotr , Marchlewska Katarzyna , Katarzynska Joanna , Gebicki Jerzy
Published: May 2024

Background: Erectile dysfunction (ED) most often has vascular etiology and usually is the earliest symptom of vascular dysfunction. The aim of this study was to evaluate vascular dysfunction with the use of the Flow-Mediated Skin Fluorescence (FMSF) technique in men with and without ED. Methods: Included were 39 men (median age 53) with ED and 40 men (median age 41.5) without ED. Medical interview, physical examination, and anthropometrical measurements were performed for all participants. The serum total testosterone, LH, and SHBG determinations were performed in patients with ED, and the Free Testosterone Index (FTI) was calculated. The FMSF technique was used to measure the microcirculatory oscillations at the baseline and to determine the flowmotion (FM) and vasomotion (VM) parameters. The Normoxia Oscillatory Index (NOI) was calculated, which represents the contribution of the endothelial (ENDO) and neurogenic (NEURO) oscillations relative to all oscillations detected at low-frequency intervals (<0.15 Hz): NOI = (ENDO + NEURO)/(ENDO + NEURO + VM). Results: In men with ED were found significantly lower FM and VM parameters, but the NOI was significantly higher in comparison to men without ED. VM and FM correlated significantly positively with erectile function, orgasmic function, and general sexual satisfaction in the whole group and the FTI in the ED group. The thresholds of 53.5 FM (AUC = 0.7) and 8.4 VM (AUC = 0.7) were predictive values for discriminating men with ED. Conclusions: It was shown that the FMSF diagnostic technique may be helpful in the early diagnosis of microcirculation dysfunction due to impaired vasomotion caused by decreased testosterone activity.
Factors Associated with Defecation Satisfaction among Japanese Adults with Chronic Constipation
Authors: Yamamoto Sayuri , Ohashi Wataru , Yamaguchi Yoshiharu , Igari Hiroki , Koshino Akira , Sugiyama Tomoya , Nagao Kazuhiro , Tamura Yasuhiro , Izawa Shinya , Mano Mamiko , Ebi Masahide , Usami Jun , Hamano Koichi , Izumi Junko , Wakita Yoshinori , Funaki Yasushi , Ogasawara Naotaka , Sasanabe Ryujiro , Sasaki Makoto , Maekawa Masato , Kasugai Kunio
Published: May 2024

Background: Constipation causes substantial morbidity worldwide. Methods: This survey assessed constipation-related factors in Japan using the Japanese version of the Irritable Bowel Syndrome Quality of Life (IBS-QOL-J) instrument. We also examined the relationship among laxative type, Bristol Stool Form Scale (BSFS) scores, and treatment cost. Finally, we examined differences in satisfaction scores according to laxative type, treatment type, treatment cost, and BSFS score. Results: IBS-QOL-J was higher among those taking salt and/or irritation laxatives. Those paying >JPY 5000 (USD 50.00) had the lowest IBS-QOL-J. IBS-QOL-J was significantly lower among those with a BSFS score of 1 or 2 (severe constipation). Conclusions: This study’s findings suggest that a variety of factors, including treatment type and cost, are associated with defecation satisfaction. Those who had hard stools, used multiple laxatives, or spent more on treatment were less satisfied. Future strategies should target therapies that do not require multiple laxatives with lower treatment costs. Adequate defecation with a small number of appropriate laxatives at minimal cost appears to improve defecation satisfaction. It is desirable to identify appropriate laxatives and improve dietary habits and exercise routines. It is also necessary to stop blindly increasing laxative usage and properly diagnose constipation disorders such as anatomical abnormalities other than functional constipation.
Diagnostics of Allergy to Furry Animals—Possibilities in 2024
Authors: Rosada Tomasz , Lis Kinga , Bartuzi Zbigniew , Grześk-Kaczyńska Magdalena , Ukleja-Sokołowska Natalia
Published: May 2024

Diagnosing allergies is not always easy. Sometimes the symptoms reported by the patient do not match the results of diagnostic tests. Diagnostics of IgE-dependent allergy, including allergy to furry animals, can be based on two basic strategies, “BOTTOM-UP” and “TOP-DOWN”, and almost all available allergy tests can be used ranging from skin tests, through specific IgE, to molecular panels and challenge tests. Currently, most information regarding the diagnosis and incidence of allergies to furry animals focuses almost exclusively on the two most common pets—dogs and cats. This is certainly due to the fact that allergy to cats and/or dogs is a common phenomenon, has a huge impact on quality of life, and is a challenge for doctors of many specialties. However, the growing number of owners of other pet species means that diagnostic methods must keep up with the changing needs of patients. Further research in these groups will certainly provide new facts and facilitate clinical decision-making when working with allergic patients.
Perioperative Management of Valvular Heart Disease in Patients Undergoing Non-Cardiac Surgery
Authors: Jalali Yashar , Jalali Monika , Števlík Ján
Published: May 2024

Postoperative cardiovascular complications (either in a hospital or within 30 days after the operation) are among the most common problems with non-cardiac surgeries (NCSs). Pre-existing cardiac comorbidities add significant risk to the development of such complications. Valvular heart disease (VHD), a rather frequent cardiac comorbidity (especially in the elderly population), can pose serious life-threatening peri-/postoperative complications. Being familiar with the recommended perioperative management of patients with VHD or an implanted prosthetic heart valve who are scheduled for NCS is of great importance in daily clinical practice. Although recently published guidelines by the European Society of Cardiology (ESC) and the American College of Cardiology and American Heart Association (ACC/AHA) for the management of VHD and perioperative management of patients undergoing NCS addresses the mentioned problem, a comprehensive review of the guidelines that provides an easy-to-use summary of the recommendations and their similarities and differences is missing in the published literature. In this review article, we summarize all of the relevant important information based on the latest data published in both guidelines needed for practical decision-making in the perioperative management of patients with VHD or after valvular repair (with prosthetic heart valve) who are scheduled for NCS.
Preparation and Tribological Behaviors of Sulfur- and Phosphorus-Free Organic Friction Modifier of Amide–Ester Type
Authors: Xu Xiaomei , Yang Fan , Yang Hongmei , Zhao Yanan , Sun Xiuli , Tang Yong
Published: May 2024

With the increasingly demanding engine conditions and the implementation of “double carbon” policies, the demand for high-quality lubricants that are cost-effective and environmentally friendly is increasing. Additives, especially high-performance friction modifiers, play an important role in boosting lubricant efficiency and fuel economy, so their developments are at the forefront of lubrication technologies. In this study, 1,3-dioleoamide-2-propyloleate (DOAPO), which incorporates polar amide, ester, and nonpolar alkyl chains, was synthesized from 1,3-diamino-2-propanol to give an eco-friendly organic friction modifier. Nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), Fourier-transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) were used to characterize the structure and thermal stability of DOAPO. Meanwhile, the storage stability and tribological behaviors of DOAPO in synthetic base oil were studied and compared with a commercial oleamide. The results show that DOAPO has better thermal stability and better storage stability in synthetic base oil. Additionally, 0.5 wt.% of DOAPO could shorten the running-in period and reduce the average friction coefficient (ave. COF) and wear scar diameter (ave. WSD) by 8.2% and 16.2%, respectively. The worn surface analysis and theoretical calculation results show that the ester bond in DOAPO breaks preferentially during friction, which can reduce the interfacial shear force and easily react with metal surfaces to form iron oxide films, thus demonstrating a better friction-reducing and anti-wear performance.
Effect of Carbon Fiber and Potassium Titanate Whisker on the Mechanical and Impact Tribological Properties of Fe-Based Impregnated Diamond Bit Matrix
Authors: Wang Zhiming , Guan Chengkai , Sun Wucheng , Tan Songcheng , Duan Longchen , Fang Xiaohong
Published: May 2024

Various contents of carbon fibers (CFs) and potassium titanate whiskers (PTWs) were added to an Fe-based impregnated diamond bit (IDB) matrix to enhance its adaptability to percussive–rotary drilling. A series of mechanical tests were conducted successively to find the effects of the reinforcing materials on the properties of the Fe-based IDB samples. Then, the fracture surfaces of the samples were analyzed via scanning electron microscopy (SEM) and energy-dispersive spectroscopy, and the worn surfaces and abrasive debris of the samples were analyzed using a laser scanning confocal microscope and SEM. The results show that both the CF and PTW can effectively improve the hardness and bending strength of an Fe-based IDB matrix, and those parameters reached their maximum values at the additive amount of 1 wt%. However, the CF had a better enhancement effect than the PTW. Furthermore, the CF improved the impact wear resistance of the IDB matrix, with a minimum wear rate of 2.38 g/min at the additive amount of 2 wt%. However, the PTW continuously weakened the impact wear resistance of the IDB matrix with increases in its content. Moreover, the morphologies of the worn surfaces indicated that the minimum roughness of the CF-reinforced IDB matrix decreased significantly to as low as 4.91 μm, which was 46.16% lower than that without CF, whereas the minimum roughness of the PTW-reinforced samples decreased by 11.31%. Meanwhile, the abrasive debris of the CF-reinforced samples was more uniform and continuous compared to that of the PTW-reinforced samples. Overall, the appropriate addition of CF or PTWs can enhance the mechanical properties of Fe-based IDB matrices, which can be used on different formations based on their impact wear resistance.
Analysis of Underwater Melting Process and Leakage Plugging Performance of Phase-Change Materials
Authors: Zhang Shenghang , Tang Lei , Li Fei , Li Po , Sima Yao , Zhao Song
Published: May 2024

Leakage is a high-incidence disease of embankment dams, and efficiently addressing this disease guarantees the safe operation of dams. Underwater leakage self-priming plugging technology is a new technology that utilizes the melting and solidifying characteristics of phase-change materials and the negative pressure in the leakage entry area to accurately plug the leakage. However, little is yet known about the underwater melting process of phase-change materials and how their characteristics influence the plugging effect. In this study, three kinds of phase-change materials, namely, paraffin, rosin, and stearic acid, were used to conduct underwater leakage self-priming plugging tests, observe and analyze the underwater melting process, and compare the plugging effects. The results showed that the underwater melting process of phase-change materials exhibited different plugging window periods depending on their melting points, specific heat capacities, and mobilities, which were the main factors affecting their plugging effects. In the final plugging stage, paraffin had the best plugging effect, but the material strength was low; rosin had good plugging compactness, but the fluidity performance was poor, and the material effective utilization was low; stearic acid had a low melting point but dispersed easily. Therefore, a blocking material with a suitable blocking window period can be produced by adjusting the material properties accordingly for an improved blocking effect.
Imaging Hyperspectral Feature Fusion for Estimation of Rapeseed Pod’s Water Content and Recognition of Pod’s Maturity Level
Authors: Zhao Zanzhong , Liao Guiping
Published: May 2024

Imaging hyperspectral technology is becoming popular in agriculture to provide detailed information on crop growth. In this work, we propose an estimation of rapeseed pod’s water content model and identification of maturity levels (green, yellow, and full) model by using this technology. Four types of hyperspectral features are extracted—color, texture, spectral three-edge parameters, and spectral indices. By integrating these features, satisfactory results are achieved: the optimal feature combination is from spectral indices and three-edge parameters, with low RRMSE and RE for yellow maturity. Incorporating spectral indices significantly improved the pod’s water content estimation, reducing RRMSE by up to 43.30% and 30.11% in the green and full maturity stages. Random forest and support vector machine with kernel method (SVM-KM) algorithms outperformed other statistical models, with SVM-KM achieving up to 96.90% accuracy in identifying maturity levels. These findings provide valuable insights for managing rapeseed production during the pod stage.
Lattice-Based Revocable Certificateless Public Key Encryption for Team Score Orienteering
Authors: Zhao You , Yan Mingyan , Yan Kaien , Li Juyan
Published: May 2024

Team score orienteering, a challenging and interesting sport, is gradually becoming known by the majority of sports enthusiasts. Integrating team score orienteering with the Internet can enhance the interactive experience for athletes. However, this integration increases the risk of the leakage of the athletes’ information. In order to protect the privacy of athletes, it is necessary to employ encryption. Therefore, this paper proposes an efficient lattice-based revocable certificateless public key encryption (RCL-PKE) scheme with decryption key exposure resistance (DKER). The adoption of certificateless encryption not only avoids the complex certificate management required for traditional public key encryption, but also addresses the key escrow problem of identity-based encryption, thereby significantly ensuring data security and privacy. Furthermore, the revocable mechanism enables the organizing committee to flexibly manage the athletes’ qualification for competitions, and DKER can effectively prevent the leakage of decryption keys, which further enhances data security. The constructed RCL-PKE scheme was proven to be IND-CPA secure under the learning with errors (LWE) assumption. Experiments indicated that the proposed RCL-PKE scheme had lower computation and communication costs, making it particularly suitable for team score orienteering.
Assessing the Performance of CO2-Mineralized Underground Backfilling Materials through the Variation Characteristics of Infrared Radiation Temperature Index
Authors: Cao Guanghui , Ma Liqiang , Osemudiamhen Arienkhe Endurance , Ngo Ichhuy , Gao Qiangqiang , Yu Kunpeng , Guo Zezhou
Published: May 2024

The utilization of CO2 mineralization fly ash (F) and coal gangue (G) technology is proposed in this research work to prepare underground backfilling materials. The test process can be divided into pre-treatment and post-treatment stages. In the pre-treatment stage, a sealed stirring vessel is used to conduct CO2 wet mineralization. The ratios of F and G were selected as follows: 20%:60% (F2G6), 30%:50% (F3G5), 40%:40% (F4G4), 50%:30% (F5G3), and 60%:20% (F6G2). The ratios were prepared into Φ50 mm × 100 mm cylindrical samples, with curing durations of 3 d, 7 d, 14 d, and 28 d. In the post-processing stage, the SANS microcomputer-controlled electronic universal testing machine and FLIR A615 infrared thermal imager were used to carry out uniaxial loading and temperature detection, respectively. The unconfined compressive strength (UCS), X-ray diffraction (XRD), average infrared radiation temperature (AIRT), variance of original infrared image temperature (VOIIT), and variance of successive minus infrared image temperature (VSMIT) of the samples were compared and analyzed. The results indicated that when curing reaches 14 d, the strength approaches its peak, with minimal changes in strength over a delayed period; furthermore, as the ratio of F to G continues to increase, the mineralization effect gradually strengthens, reaching its optimum level at a ratio of 5:3. However, when the ratio exceeds 5:3, signs of deteriorating mineralization effect start to appear. During the loading process, the AIRT of the mineralized samples showed a continuous increase, but the VOIIT and VSMIT of the mineralized sample both exhibited significant fluctuations or rapid increases during damage rupture. Moreover, the rise in the AIRT value was found to be linked to the increase in the ratio of F to G. This indicates that F has a higher thermal–mechanical conversion efficiency compared to G, so the temperature change will be greater during the loading process. The drastic changes in the VOIIT and VSMIT indicate that they can be used as sensitive response indicators for sample rupture, and can predict and warn of damage rupture in mineralized samples. Research work can provide practical guidance and reference for underground backfilling of CO2 mineralization industrial waste.
Zircon U-Pb Geochronology, Geochemistry, and Sr-Nd-Hf Isotopic Composition of Ben Giang-Que Son Complex in the Southern Truong Son Belt: Implications for Permian–Triassic Tectonic Evolution
Authors: Nguyen Thuy Thi Bich , Hieu Pham Trung , Xin Qian , Anh Bui The , Xuan Nguyen Thi , Minh Pham , Thu Ho Thi
Published: May 2024

The magmatic rocks of the Ben Giang-Que Son complex exposed in the southern part of the Truong Son belt have petrographic compositions including gabbro, gabbrodiorite, granodiorite, and granite. Geochemically, the magmatic rocks are of subalkaline affinity and belong to the high-K calc-alkaline series. All analyzed samples contain hornblende and biotite as mafic minerals and are defined as metaluminous with a aluminum saturation index of <1.1. Chondrite-normalized rare earth element diagrams are characterized by fractionation between light and heavy rare earth elements and show small to moderate negative Eu anomalies (Eu/Eu* = 0.81–0.44). Primitive mantle-normalized trace element patterns exhibit enrichment in LILEs such as Rb, K, U, and especially Pb and depletion of HFSEs (Nb, Ta, and Ti), indicating arc-magma. The BG-QS gabbro and gabbrodiorite have low Cr, Co, and Ni and display enrichment in 87Sr/86Sr (0.7084 to 0.7147), ꜪNd(t) (−0.5 to −1.9), and positive ꜪHf(t) (+2.4 to 4.5), suggesting generation from the enriched mantle source. The BG-QS diorite and granodiorite contain small mafic enclaves, have a wide range of SiO2 contents and enrichment in Sr-Nd isotopes (87Sr/86Sr = 0.7109–0.7178; ꜪNd(t) = −3.3 to −3.7), and display high Mg# (43–51). All these features indicate that they were formed by the mixing of magmas, which originated from an enriched mantle source and the pre-existing juvenile mafic lower crust. The whole-rock Nd and zircon Hf model ages are of 1160–760 Ma. The Ben Giang-Que Son complex yields LA-ICP-MS zircon U-Pb ages of 285 ± 3.1 and 278 ± 3.5 Ma that corresponds to the Cisuralian epoch (early Permian), which is linked to the subduction and amalgamation of the Indochina and South China blocks due to the closing a branch of the Paleotethys along the Song Ma suture.
Microstructure Evolution Law of Ionic Rare Earth at Different Depths in In Situ Leaching Mine Site
Authors: Guo Zhongqun , Wang Haoxuan , Liu Qiqi , Luo Feiyue , Liu Yanshuo
Published: May 2024

Due to the inhomogeneity and anisotropy of mine rock bodies, ionic rare earth ore bodies exhibit varying pore structures at different depths. This research focuses on an ionic rare earth mine in Fujian Province, where in situ ore samples rather than remodeled soil samples were studied. Samples from the fully weathered layer at depths of 1 m, 12 m, and 21 m, both before and after leaching, were collected for onsite analysis. Microscopic pore characteristics were evaluated using scanning electron microscopy, and digital image processing was utilized to study the evolution of the pore scale, distribution, and shape in rare earth ore samples at various depths pre- and post-leaching. The results indicate an increase in the ore body’s porosity with the depth of the ore samples both before and after leaching. The variation in pore scale is predominantly dictated by the ratio of macropore and large pores. Pre-leaching, the middle ore sample showcased the highest uniformity, with the upper part being the most irregular. Post-leaching, the highest uniformity was observed in the lower ore samples, with the upper part remaining irregular. Pre-leaching, as depth increased, the pore distribution in ore samples became more dispersed, with decreasing orderliness. Post-leaching, the orderliness was most improved in upper ore samples, while middle ore samples became the least orderly. Additionally, before leaching, pore-shape roughness increased with depth; after leaching, the pore shape became more rounded as depth increased, simplifying the pore-shape structure of the ore samples both before and after leaching.
Peculiar Features of Lime-Treated Pyroclastic Soils through a Multi-Scale Experimental Investigation
Authors: Cecconi Manuela , Russo Giacomo
Published: May 2024

Soil-improvement techniques with binders are used in several geotechnical engineering applications as a sustainable solution for the reuse of waste soils. Due to their inherent complexity and their mechanical behaviour, pyroclastic soils are generally considered waste geomaterials in their natural state. Lime treatment of pyroclastic soils can be considered a viable solution for their reuse in geotechnical applications. In this paper, some peculiar features of the chemo-physical evolution and mechanical behaviour of lime-treated pyroclastic soils are evidenced through a multi-scale experimental investigation. While, for clayey soils, the fine fraction is mainly responsible for ion exchange and pozzolanic reactions induced by lime, for pyroclastic soils, pozzolanic reactions are dominant processes due to the low quantity of clay minerals along with the abundance of aluminates and silicates as the main constituents of their amorphous phase. The link between the phenomena detected at the microscale level, the mineralogical composition, and the macroscopic behaviour of two lime treated pyroclastic soils of different origin is explored through a multiscale approach.
An Optical Reusable 2D Radiochromic Gel-Based System for Ionising Radiation Measurements in Radiotherapy
Authors: Kozicki Marek , Maras Piotr
Published: May 2024

This work describes the development of a reusable 2D detector based on radiochromic reaction for radiotherapy dosimetric measurements. It consists of a radiochromic gel dosimeter in a cuboidal plastic container, scanning with a flatbed scanner, and data processing using a dedicated software package. This tool is assessed using the example of the application of the coincidence test of radiation and mechanical isocenters for a medical accelerator. The following were examined: scanning repeatability and image homogeneity, the impact of image processing on data processing in coincidence tests, and irradiation conditions—monitor units per radiation beam and irradiation field are selected. Optimal conditions for carrying out the test are chosen: (i) the multi-leaf collimator gap should preferably be 5 mm for 2D star shot irradiation, (ii) it is recommended to apply ≥2500–≤5000 MU per beam to obtain a strong signal enabling easy data processing, (iii) Mean filter can be applied to the images to improve calculations. An approach to dosimeter reuse with the goal of reducing costs is presented; the number of reuses is related to the MUs per beam, which, in this study, is about 5–57 for 30,000–2500 MU per beam (four fields). The proposed reusable system was successfully applied to the coincidence tests, confirming its suitability as a new potential quality assurance tool in radiotherapy.
Radical Cyclization-Initiated Difunctionalization Reactions of Alkenes and Alkynes
Authors: Zhi Sanjun , Ma Xiaoming , Zhang Wei
Published: May 2024

Radical reactions are powerful in the synthesis of diverse molecular scaffolds bearing functional groups. In previous review articles, we have presented 1,2-difunctionalizations, remote 1,3-, 1,4-, 1,5-, 1,6- and 1,7-difunctionalizations, and addition followed by cyclization reactions. Presented in this paper is radical cyclization followed by the second functionalization reaction. The second functionalization could be realized by atom transfer reactions, radical or transition metal-assisted coupling reactions, and reactions with neutral molecules, cationic and anionic species.
Solid State and Solution Structures of Lanthanide Nitrate Complexes of Tris-(1-napthylphosphine oxide)
Authors: Coles Simon J. , McCormick McPherson Laura J. , Platt Andrew W. G. , Singh Kuldip
Published: May 2024

Coordination complexes of lanthanide metals with tris-1-naphthylphosphine oxide (Nap3PO, L) have not been previously reported in the literature. We describe here the formation of lanthanide(III) nitrate complexes Ln(NO3)3L4 (Ln = Eu to Lu) and the structures of [Ln(NO3)3L2]·2L (Ln = Eu, Dy, Ho, Er) and L. The core structure of the complexes is an eight-coordinate [Ln(NO3)3L2] with the third and fourth ligands H-bonded via their oxygen atoms to one of the naphthyl rings. The structures are compared with those of the analogous complexes of triphenylphosphine oxide and show that the Ln-O(P) bond in the Nap3PO complexes is slightly longer than expected on the basis of differences in coordination numbers. The reaction solutions, investigated by 31P and 13C NMR spectroscopy in CD3CN, show that coordination of L occurs across the lanthanide series, even though complexes can only be isolated from Eu onwards. Analysis of the 31P NMR paramagnetic shifts shows that there is a break in the solution structures with a difference between the lighter lanthanides (La–Eu) and heavier metals (Tb–Lu) which implies a minor difference in structures. The isolated complexes are very poorly soluble, but in CDCl3, NMR measurements show dissociation into [Ln(NO3)3L2] and 2L occurs.
Spirulina (Arthrospira platensis) Improved Nonalcoholic Fatty Liver Disease Characteristics and Microbiota and Did Not Affect Organ Fibrosis Induced by a Fructose-Enriched Diet in Wistar Male Rats
Authors: Fakhoury-Sayegh Nicole , Hamdan Aya , Lebbos Sarah , Itani Tarek , Trak-Smayra Viviane , Khazzaka Aline , Dagher-Hamalian Carole , Sayegh Lea Nicole , Mallah May , Obeid Omar , Sayegh Raymond
Published: May 2024

Spirulina (Arthrospira platensis) is reported to play a role in improving nonalcoholic fatty liver disease (NAFLD) and intestinal microbiota (IM). To study spirulina’s effects in the improvement of NAFLD characteristics, IM, and pancreatic–renal lesions induced by a fructose-enriched diet, 40 Wistar healthy male rats, weighing 200–250 g, were randomly divided into four groups of 10, and each rat per group was assigned a diet of equal quantities (20 g/day) for 18 weeks. The first control group (CT) was fed a standardized diet, the second group received a 40% fructose-enriched diet (HFr), and the third (HFr-S5) and fourth groups (HFr-S10) were assigned the same diet composition as the second group but enriched with 5% and 10% spirulina, respectively. At week 18, the HFr-S10 group maintained its level of serum triglycerides and had the lowest liver fat between the groups. At the phylae and family level, and for the same period, the HFr-S10 group had the lowest increase in the Firmicutes/Bacteroidetes ratio and the Ruminococcaceae and the highest fecal alpha diversity compared to all other groups (p < 0.05). These findings suggest that at a 10% concentration, spirulina could be used in nutritional intervention to improve IM, fatty liver, metabolic, and inflammatory parameters associated with NAFLD.
Dietary Fiber-Derived Butyrate Alleviates Piglet Weaning Stress by Modulating the TLR4/MyD88/NF-κB Pathway
Authors: Huangfu Weikang , Ma Jixiang , Zhang Yan , Liu Mengqi , Liu Boshuai , Zhao Jiangchao , Wang Zhichang , Shi Yinghua
Published: May 2024

During weaning, piglets are susceptible to intestinal inflammation and impairment in barrier function. Dietary fiber (DF) plays an active role in alleviating weaning stress in piglets. However, the effects of different sources of dietary fiber on the performance of weaned piglets are inconsistent, and the mechanisms through which they affect intestinal health need to be explored. Therefore, in this study, sixty weaned piglets were randomly divided into three treatment groups: basal diet (control, CON), beet pulp (BP), and alfalfa meal (AM) according to the feed formulation for a 28-day trial. The results showed that both AM and BP groups significantly reduced diarrhea rate and serum inflammatory factors (IL-1β and TNF-α) and increased antioxidant markers (T-AOC and SOD), in addition to decreasing serum MDA and ROS concentrations in the AM group. At the same time, piglets in the AM group showed a significant reduction in serum intestinal permeability indices (LPS and DAO) and a substantial increase in serum immunoglobulin levels (IgA, IgG, and IgM) and expression of intestinal barrier-associated genes (Claudin1, Occludin, ZO-1, and MUC1), which resulted in an improved growth performance. Interestingly, the effect of DF on intestinal inflammation and barrier function can be attributed to its modulation of gut microbes. Fiber-degrading bacteria enriched in the AM group (Christensenellaceae_R-7_group, Pediococcus and Weissella) inhibited the production of TLR4- through the promotion of SCFAs (especially butyrate). MyD88-NF-κB signaling pathway activation reduces intestinal inflammation and repairs intestinal barrier function. In conclusion, it may provide some theoretical support and rationale for AM to alleviate weaning stress and improve early intestinal dysfunction, which may have implications for human infants.
The Role of Senescent CD8+T Cells in the Pathogenesis of Disseminated Leishmaniasis
Authors: Abreu Cayo A. , Nascimento Maurício Teixeira , Bacellar Olívia , Carvalho Lucas Pedreira , Carvalho Edgar Marcelino , Cardoso Thiago Marconi
Published: May 2024

Disseminated leishmaniasis (DL) caused by L. braziliensis is characterized by the presence of 10 to more than 1000 lesions spread on the body. While protection against Leishmania is mediated by macrophages upon activation by IFN-γ produced by CD4+T cells, the pathology of disseminated leishmaniasis (DL) could be mediated by macrophages, NK, and CD8+T cells. Herein, we evaluate the participation of senescent CD8+T cells in the pathogenesis of DL. Methods: Peripheral blood mononuclear cells (PBMCs), biopsies, co-cultures of CD8+T cells with uninfected and infected macrophages (MØ), and PBMC cultures stimulated with soluble L. braziliensis antigen (SLA) for 72 h from patients with cutaneous leishmaniasis (CL) and DL were used to characterize senescent CD8+T cells. Statistical analysis was performed using the Mann–Whitney and Kruskal–Wallis tests, followed by Dunn’s. Results: Patients with DL have an increase in the frequency of circulating CD8+T cells that present a memory/senescent phenotype, while lesions from DL patients have an increase in the frequency of infiltrating CD8+T cells with a senescent/degranulation phenotype. In addition, after specific stimuli, DL patients’ circulating CD8+T with memory/senescent profile, showing degranulation characteristics, increased upon SLA stimuli, and those specific CD8+T cells from DL patients had an increased degranulation phenotype, causing more apoptosis of infected target cells. Conclusions: DL patients show a higher frequency of cytotoxic senescent CD8+T cells compared to CL patients, and that could promote the lysis of infected cells, although without parasite killing, releasing Leishmania to the extracellular compartment, contributing to the spread of parasites.
RETRACTED: Ali et al. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants 2021, 10, 25
Authors: Ali Aaliya , Garg Prakrati , Goyal Rohit , Kaur Gurjot , Li Xiangkai , Negi Poonam , Valis Martin , Kuca Kamil , Kulshrestha Saurabh
Published: May 2024

The journal retracts the article, “A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing” [...]
Comparative Antioxidant Activity and Untargeted Metabolomic Analyses of Sour Cherry Cultivars Based on Ultra-Performance–Time of Flight–Mass Spectrometry
Authors: Kaur Prabhjot , Darwish Ahmed G. , El-Sharkawy Islam , Singh Ashutosh , Subramanian Jayasankar
Published: May 2024

This study was conducted for the comparative analysis of antioxidant activity and untargeted metabolomics of dark- and light-colored sour cherry cultivars grown in Canada. Based on our previous study, we selected four cultivars—‘Heimann R’, ‘Gorsemska’, V70142, and ‘Montmorency’—to determine the untargeted metabolites and their role in antioxidant activities. A total of 473 metabolites were identified from four sour cherry genotypes using UPLC–ToF–MS. Untargeted metabolomics revealed the dominant chemical groups present in sour cherries. PCA showed that the diversity in sour cherry metabolites was due to the genotype differences indicating iditol, malic acid, chlorobenzene, 2-mercaptobenzothiazole, and pyroglutamic acid as the predominant contributors. The variable importance in the projection (VIP > 1.0) in partial least-squares–discriminant analysis described 20 biomarker metabolites representing the cherry metabolome profiles. A heatmap of Pearson’s correlation analysis between the 20 biomarker metabolites and antioxidant activities identified seven antioxidant determinants that displayed the highest correlations with different types of antioxidant activities. TPC and TAC were evaluated using the Folin–Ciocalteu method. The total antioxidant activity was performed using three different assays (ABTS, FRAP, and DPPH). This study of correlating metabolomics and antioxidant activities elucidated that the higher nutritional value and biological functions of sour cherry genotypes can be useful for the development of nutraceutical and functional foods.
Biodegradable Conducting Polymer-Based Composites for Biomedical Applications—A Review
Authors: Khan Tabrej , Vadivel Gayathri , Ramasamy Balan , Murugesan Gowtham , Sebaey Tamer A.
Published: May 2024

In recent years, researchers have increasingly directed their focus toward the biomedical field, driven by the goal of engineering polymer systems that possess a unique combination of both electrical conductivity and biodegradability. This convergence of properties holds significant promise, as it addresses a fundamental requirement for biomedical applications: compatibility with biological environments. These polymer systems are viewed as auspicious biomaterials, precisely because they meet this critical criterion. Beyond their biodegradability, these materials offer a range of advantageous characteristics. Their exceptional processability enables facile fabrication into various forms, and their chemical stability ensures reliability in diverse physiological conditions. Moreover, their low production costs make them economically viable options for large-scale applications. Notably, their intrinsic electrical conductivity further distinguishes them, opening up possibilities for applications that demand such functionality. As the focus of this review, a survey into the use of biodegradable conducting polymers in tissue engineering, biomedical implants, and antibacterial applications is conducted.