bluuebunny/crossref_metadata_2025 huggingface dataset:
Authors: Fatchurohmah Wiwiek , Muflikhah Khusnul , Mustofa Mustofa , Candrawati Susiana , Madani Arya Indra
Published: September 2023

Cardiorespiratory fitness is an indicator of a person's fitness and a predictor of cardiometabolic diseases such as diabetes mellitus, coronary heart disease, and stroke. One of the organs that play a role in cardiorespiratory fitness is the lungs. Thus, lung function has the potential to be a predictor of cardiorespiratory fitness. This study aims to determine the relationship between lung function and the level of cardiorespiratory fitness in students of the Faculty of Medicine, Jenderal Soedirman University. As many as 29 male subjects aged 18-25 years became research subjects. The consecutive sampling technique was used to recruit the subjects. Lung function was measured by spirometry to determine the value of Forced Vital Capacity (FVC), Force Expiratory Volume in 1 second (FEV1), and the FEV1/FVC ratio. The average predicted percent value of FVC, FEV1 predicted percent value, FEV1/FVC ratio, and the mean cardiorespiratory fitness index in subjects were 80.82 ± 2.72%; 87.17±2.71%; 94.87±0.63%; 65.88±3.575, respectively. The Pearson correlation test showed no relationship between FVC, FEV1, and the FEV1/FVC ratio on cardiorespiratory fitness, with p values ​​of 0.324; 0.284; and 0.231 (p>0.05), respectively. In conclusion, there is no relationship between lung function and the level of cardiorespiratory fitness in students of the Faculty of Medicine, Jenderal Soedirman University
Authors: Sylviningrum Thianti , Putranti Ismiralda Oke , Ardianto Ferdi Wiweko
Published: September 2023

Background: Herpes zoster (HZ) is a vesicular eruptive disease affecting the skin and peripheral nerves due to the reactivation of the Varicella Zoster Virus (VZV). VZV reactivation can cause neuropathy and vesicular skin lesions distributed according to nerve dermatomes. Rarely encountered neuropathy of the enteric nervous system can take the form of intestinal pseudo-obstruction with clinical features of paralytic ileus. We report a case of HZ with a clinical picture resembling paralytic ileus which, if treated late, will increase the morbidity and mortality of the sufferer.
Case Presentation: A 59-year-old man came to the hospital emergency room with complaints of abdominal hardness, wall tension, pain, and inability to fart and defecate followed by plentiful water contents from the abdomen to the right back. Physical examination showed decreased bowel sounds and eruption of vesicular lesions with erythematous skin base distributed dermatomal T8-10 dextra. Blood tests showed elevated monocytes and hyperglycemia, while abdominal radiology showed dilated colon and normal air distribution in the colon. Tzanck's test revealed multinucleated giant cells. The patient was diagnosed with HZ and showed improvement after being given orally acyclovir and gabapentin.
Summary: Neuropathy of the enteric nervous system due to VZV infection needs to be considered in the paralytic ileus clinical manifestation accompanied by vesicular skin lesions pathognomonic for HZ
The distribution of mangrove area, mangrove density, and species diversity on the North Coast of Jakarta
Authors: Usman Uus , Hilmi Endang , Iqbal Achmad
Published: September 2023

The distribution of mangrove area, density, and species diversity on the North Coast of Jakarta indicate the mangrove adaptation to live and grow in permanent water inundation areas. Therefore, this research aimed to analyze the distribution and mapping of the mangrove ecosystem in permanent water inundation area using the index of mangrove density, diversity, and geographical information system. The results showed that soil water salinity ranged from 5.6 to 7.0 ppt, water salinity ranged from 0.1 to 9.8 ppt, soil water pH ranged from 6.25 to 7,0, water pH ranged from 5.83 to 6.5, soil nitrate ranged from 12.2 to 22.8 mg/L, soil phosphate ranged from 1.7 to 14.8 mg/L, soil pyrite ranged from 0.12 to 0.3 mg/L, and soil texture varied from silt loam to silty clay loam. The mangrove ecosystem on the North Jakarta was dominated by a very rare density and low–moderate diversity, with a density between 440–1,250 trees/ha. The distribution of mangrove area also showed a very rare density from 0.18 ha (2000) to 166.95 ha (2020), a rare from 197.03 ha (2000) to 359,72 ha (2020), the moderate from 263.65 ha (2000) to 351.09 ha (2020), the dense from 591.78 (2000) to 273.92 ha (2020), and the very dense from 486.35 ha (2000) to 98.91 ha (2020). The mangrove ecosystem in the North Coast Jakarta was dominated by Avicennia marina, Rhizophora mucronata, Rhizophora apiculata, Rhizophora stylosa, Nypa frutican, Sonneratia alba and Sonneratia caseolaris.   The conclusions of this research showed that the mangrove ecosystem inJakarta is degraded because it is dominated by rare- very rare of mangrove density Keywords: mangrove distribution, mangrove density and diversity, North Coast of Jakarta, permanent water inundation
Effectiveness of Filter Media Compositions on Water Quality, Growth and Survival Rate of Tilapia (Oreochromis niloticus) Cultured in Recirculation System
Authors: Lailiyah Mamluatul , Harwanto Dicky , Desrina Desrina
Published: September 2023

Market demand for tilapia (Oreochromis niloticus) is increasing every year. This has encouraged aquaculture companies to apply intensive cultivation systems. However, these applications run the risk of increasing waste and decreasing water quality. One strategy to overcome those problems of water quality is to use recirculation aquaculture system. This study aims to determine the effectiveness of filter media composition on water quality, survival rate, and tilapia growth. The average body weight of the fish used was 3.84 ± 0.05 g per individual. A completely random experiment design with three treatments and three replications were applied. The treatments were combination of several filter media with different compositions, namely A (Dacron + 75% nets + 25% sand), B (Dacron + 50% nets + 50% sand) and C (Dacron + 25% nets + 75% sand).The water quality variables measured were pH, DO, temperature, ammonia, and VTR (Volumetric TAN Removal). The survival rate (SR), relative growth rate (RGR). and total amount feed fed (TFF) of fish were also measured. The results showed that the composition of the filter had a significant effect (P<0.05) between treatment. The best VTR was showed in Treatment C with value 54.65 gm-3d-1.Keywords: Tilapia, recirculation, dacron, nets, sand
Pelatihan Decoding Texts untuk Mengembangkan Penguasaan Kosakata Bahasa Inggris dan Kemampuan Penerjemahan Siswa
Authors: Ficayuma Lina Aris
Published: September 2023

Program English camp yang berisi pelatihan decoding texts dan memorizing vocabulary ini dilaksanakan secara hybrid learning. Tujuan pengabdian yang dilaksanakan di SMPIT Insan Kamil Sidoarjo ini adalah untuk membekali siswa-dan siswi mampu menerjemahkan teks Bahasa Inggris dengan baik dan benar. Salah satu caranya dengan pelatihan decoding text dan memorizing vocabularies yang dilaksanakan selama satu bulan penuh. Selain itu, kegiatan juga bertujuan membentuk generasi muslim yang berkarakter. Metode yang dilakukan dalam kegiatan English Camp ini yaitu dalam bentuk pengajaran, pelatihan, pendampingan dan evaluasi. Pelatihan ini menargetkan level A yaitu basic user dan grade A1 (break-through) berdasarkan CEFR dengan konversi nilai KKM 75, dan 300 kosakata. Pengabdian ini dilaksanakan selama 1 bulan dengan melibatkan 5 koordinator, 12 walikelas, 7 dosen, 59 siswi dan 60 siswa. Monitoring perkembangan kemampuan menerjemahkan siswa dan siswi dipantau melalui kegiatan harian dan pekanan. Sebagai bentuk evaluasi, akhir pekan dilaksanakan ujian pekanan dan post-test diakhir bulan. Keefektifan kegiatan ini juga dievaluasi oleh siswa dan siswi dengan mengisi angket layanan kepuasan. Hasil menunjukkan bahwa secara keseluruhan siswa dan siswi mendapatkan NA 9.30, dengan rincian kelas putra NA 92.67 dan kelas putri lebih unggul yaitu NA 96. Hasil nilai decoding telah melampaui KKM dan mencapai target A1 dengan tingkatan tertinggi, advanced basic user. Sedangkan rata-rata penguasaan vocabulary selama 1 bulan yaitu 280 kata, dengan batas bawah 225 kata dan batas tertinggi 338 kata, serta rata-rata pada tingkatan tertinggi yaitu advanced starter. Kemudian berdasarkan hasil angket, 96% siswa dan siswi menjawab puas dengan pelatihan ini.
Diagnostic Accuracy of a Portable Electromyography and Electrocardiography Device to Measure Sleep Bruxism in a Sleep Apnea Population: A Comparative Study
Authors: Cid-Verdejo Rosana , Domínguez Gordillo Adelaida A. , Sánchez Romero Eleuterio A. , Ardizone García Ignacio , Martínez Orozco Francisco J.
Published: September 2023

Background: The gold standard for the diagnosis of sleep bruxism (SB) and obstructive sleep apnea (OSA) is Polysmnography (PSG). At the end of the apnea episodes there is frequently a final hy-permotor muscle activity that could act as a confusion factor in the diagnosis of SB with the elec-tromyography portable devices. The aim of this study was to compare the concordance on the number of episodes of SB in a population with OSA, between the diagnosis obtained by PSG, an-alyzed manually by a neurophysiologist and that obtained manually and automatically by a portable electromyography (EMG) and electrocardiography (EKG) device. Methods: Twenty-three subjects underwent one night of polysomnographic study with simulta-neous recording with the EMG-EKG device. The variables referring to the number of episodes and the SB index measured with both tools and analyzed in the manual and automatic modes were compared. Masticatory muscle activity was scored according to published criteria. The sample was segmented by severity of OSA according to AASM criteria. ANOVA, correlations, and the Bland–Altman plot were used to quantify the agreement between both methods. The concordance was calculated through the ICC. Results: The total events of SB per night in the PSG study were on average (8.17), lower than the one obtained with EMG-EKG manual analysis (14.13) and automatic (29.26). Both the SB PSG and Manual EMG-EKG episodes decrease from non-OSA (PSG = 16 ± 13,55, EMG-EKG = 16,83 ±11,58) to severe OSA (PSG = 3,14 ± 4,26, EMG-EKG = 9,86 ± 8,09). However, in the case of automatic EMG-EKG mode: the number of SB episodes in severe OSA doubled (41,23 ± 12,50) with respect to non OSA (24,50 ± 12,19). On average: the EMG-EKG device Automatic analysis measures 21.08 units more than PSG. The results with the manual EMG-EKG analysis improved. Conclusion: There is no concordance between the results obtained in the PSG neurophysiologic analysis and those obtained by means of the EMG-EKG device automatic and manual analysis for the diagnosis of SB in a population mostly with OSA. The OSA could act as a confusion factor in the diagnosis of SB with the electromyography portable devices, but further study is needed.
A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2
Authors: Thimmiraju Syamala Rani , Adhikari Rakesh , Villar Maria J , Lee Jungsoon , Liu Zhuyun , Kundu Rakhi , Chen Yi-Lin , Sharma Suman , Ghei Karm , Keegan Brian , Versteeg Leroy , Gillespie Portia M , Ciciriello Allan , Yesmin Nelufa , Poveda Cristina , Uzcategui Nestor , Chen Wen-Hsiang , Kimata Jason T , Zhan Bin , Strych Ulrich , Bottazzi Maria Elena , Hotez Peter , Pollet Jeroen
Published: September 2023

(1) Background: We previously reported the development of a recombinant protein SARS-CoV-2 vaccine, consisting of the Receptor-Binding Domain (RBD) of the SARS-CoV-2 spike protein, adjuvanted with aluminum hydroxide (alum) and CpG oligonucleotides. In mice and non-human primates, our original RBD vaccine induced high neutralizing antibody titers against the wild-type (WT) isolate of the virus, and, with partners in India and Indonesia it was later developed into two closely resembling human vaccines, Corbevax and Indovac, respectively. Here, we describe the development and characterization of a next-generation vaccine adapted to the recently emerging XBB variants of SARS-CoV-2. (2) Methods: We conducted preclinical studies in mice using a novel yeast-produced SARS-CoV-2 XBB.1.5 RBD subunit vaccine candidate formulated with alum and CpG. We examined the neutralization profile of sera obtained from mice vaccinated twice intramuscularly at a 21-day interval with the XBB.1.5-based RBD vaccine, against WT, Beta, Delta, BA.4, BQ.1.1, BA.2.75.2, XBB.1.16, and XBB.1.5 SARS-CoV-2 pseudoviruses. (3) Results: The XBB.1.5 RBD/CpG/alum vaccine induced a robust production of antibodies in mice that demonstrated strong neutralization of the XBB.1.5 pseudovirus and multiple other Omicron pseudoviruses. However, regardless of high antibody cross-reactivity by ELISA, the anti-XBB.1.5 RBD antigen serum showed low neutralizing titers against the WT and Delta virus variants. (4) Conclusions: Whereas we observed modest cross-neutralization against Omicron subvariants by sera from mice vaccinated with the original RBD/CpG/Alum vaccine or with the BA.4/5-based vaccine, sera raised against the XBB.1.5 RBD showed robust cross-neutralization. These findings underscore the opportunity for an updated vaccine formulation utilizing the XBB.1.5 RBD antigen.
Ultrasonic Non-Contact Air-Coupled Technique For Assessment Of Sandwich Composites Plates Using Antisymmetric Lamb Waves
Authors: Moreno Eduardo , Giacchetta Roberto , Gonzalez Ricardo , Sanchez David , Sanchez Olalla , Torre Andrea , Cosarinsky Guillermo , Coelho Wagner
Published: September 2023

This paper describes the design and implementation of an ultrasonic non-contact air-coupled technique (UNCACT) using antisymmetric Lamb waves (ALW) for NDT assessment in novel composite sandwich plates of the car body shell. This technique is complemented with a C-Scan image implementation using this kind of guided waves. The finite element method using Comsol 6.1 is developed for the interpretation of the several wave modes presented in the experiments, including the ALW mode. The phase velocity method (PVM) is applied for the verification of the ALW mode in the portion of the RF signal necessary in the C-Scan image.
Innate Immune Pathways in Atherosclerosis – from Signaling to Long-Term Epigenetic Reprogramming
Authors: Aronova Arailym , Tosato Federica , Naser Nawraa , Asare Yaw
Published: September 2023

Innate immune pathways play a crucial role in the development of atherosclerosis, from sensing initial danger signals to the long-term reprogramming of immune cells. Despite the success of lipid-lowering therapy, anti-hypertensive medications, and other measures in reducing complications associated with atherosclerosis, cardiovascular disease (CVD) remains the leading cause of death worldwide. Consequently, there is an urgent need to devise innovative preventive and therapeutic strategies to alleviate the global burden of CVD. Extensive experimental research and epidemiological studies have demonstrated the dominant role of innate immune mechanisms in the progression of atherosclerosis. Recently, landmark trials including CANTOS, COLCOT, and LoDoCo2 have provided solid evidence, demonstrating that targeting innate immune pathways can effectively reduce the risk of CVD. These groundbreaking trials mark a significant paradigm shift in the field and open new avenues for atheroprotective treatments. It is therefore crucial to comprehend the intricate interplay between innate immune pathways and atherosclerosis for the development of targeted therapeutic interventions. Additionally, unraveling the mechanisms underlying the long-term reprogramming may offer novel strategies to reverse the pro-inflammatory phenotype of immune cells and restore immune homeostasis in atherosclerosis. In this Review, we present an overview of the innate immune pathways implicated in atherosclerosis, with a specific focus on the signaling pathways driving chronic inflammation in atherosclerosis and the long-term reprogramming of immune cells within the atherosclerotic plaque. Elucidating the molecular mechanisms governing these processes presents exciting opportunities for the development of a new class of immunotherapeutic approaches aimed at reducing inflammation and promoting plaque stability. By addressing these aspects, we can potentially revolutionize the management of atherosclerosis and its associated cardiovascular complications.
Mechanisms of Endothelial Cell Membrane Repair: Progress and Perspectives
Authors: Zha Duoduo , Wang Shizhen , Nichols Paula , Qian Yisong , Sampath Venkatesh , Fu Mingui
Published: September 2023

Endothelial cells are the crucial inner lining of blood vessels, pivotal in vascular homeostasis and integrity. However, these cells are perpetually subjected to a myriad of mechanical, chemical, and biological stresses that can compromise their plasma membranes. A sophisticated repair system involving key molecules, such as calcium, annexins, dysferlin, and MG53, is essential for maintaining endothelial viability. These components orchestrate complex mechanisms, including exocytosis and endocytosis, to repair membrane disruptions. Dysfunctions in this repair machinery, often exacerbated by aging, are linked to endothelial cell death, subsequently contributing to the onset of atherosclerosis and the progression of cardiovascular diseases (CVD) and stroke, major causes of mortality in the United States. Thus, identifying the core machinery for endothelial cell membrane repair is critically important for understanding the pathogenesis of CVD and stroke and developing novel therapeutic strategies for combating CVD and stroke. This review summarizes the recent advances in understanding the mechanisms of endothelial cell membrane repair. The future directions of this research area are also highlighted.
Demographic Analysis of Active Travel Users in Urban Context
Authors: Jaber Ahmed , Hamadneh Jamil
Published: September 2023

Active transportation, such as walking, cycling, and micro-mobility modes, has received a lot of attention in recent years due to its potential benefits to urban residents, such as less traffic, better air quality, more opportunities to get exercise, and an overall higher quality of life. In this study, we used Classification and Regression Trees (CART) to compare and contrast three mobility options: shared micro-mobility, individual micro-mobility, and walking. We surveyed 219 people living in Budapest, Hungary, to learn more about their travel habits and investigate the demographic elements that influence people's mode choice, such as age, gender, ownership of micro-mobility modes, education, job, and income. Results showed that ownership of personal micro-mobility modes, and age as important predictors of active travel mode choice. Males seem to prioritize cost and weather conditions when choosing shared micromobility modes, while females value safety and weather conditions. Our findings can guide policy decisions and urban planning initiatives by identifying the most significant predictors of mode choice and evaluating the possible benefits and drawbacks of each mode.
Uncovering the Hidden Burden of Pharmaceutical Poisoning in High-Income and Low-Middle-Income Countries: A Scoping Review
Authors: Cowans Claire , Love Anya , Tangiisuran Balamurugan , Jacob Sabrina Anne
Published: September 2023

Pharmaceutical poisoning is a significant global public health concern, causing approximately 190,000 deaths yearly. This scoping review aims to comprehensively map the available literature on pharmaceutical poisoning and compare patterns between high-income countries (HICs) and low-middle-income countries (LMICs). A systematic search was performed across the following databases: Embase, PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and CINAHL. Studies included were from 1st January 2011 to 31st December 2020, in English, with full text available. Seventy-nine articles were included in the study; 21 were from LMICs and 58 were from HICs. The toxic exposure was largely intentional (77%) in LMICs and accidental (68%) in HICs. Drugs acting on the nervous system were responsible for 95% of toxicities worldwide with analgesics accounting for the largest subtherapeutic group in both LMICs (40%) and HICs (58%). Notable statistics were that HICs accounted for 99% of opioid overdoses, and LMICs accounted for 19% of anti-epileptic-induced toxicities. Overall, the medical outcomes of poisonings were generally worse in LMICs. The review provides possible interventions to target specific geographic locations, based on the trends identified, to reduce the burden worldwide. Many gaps within the literature were recognised, calling for more robust analytical research.
Three-Dimensional Coordinate Calibration Models for Augmented Reality Applications in Indoor Industrial Environments
Authors: Nunes Jandson , Almeida Fabio , Silva Leonardo , Santos Vinicius , Senna Valter , Winkler Ingrid
Published: September 2023

The calibration of three-dimensional (3D) coordinates in augmented reality (AR) systems is a complex activity. It involves the recognition of environmental characteristics and technology that models the 3D space of the device, determining its position and orientation. In the industrial environment, it is common for AR applications to cover large spaces, making it difficult to maintain attributes such as precision and accuracy. The set of sensors and mapping algorithms available in HoloLens stimulate the development of virtual reality (VR) applications, in particular localization techniques. This study proposes calibration models of the 3D coordinates of the HoloLens for indoor industrial environments. The performance of tests in a relevant environment provides data necessary to evaluate the performance of the proposed models in terms of precision and accuracy in determining point coordinates in the study environment. The results show improvements in determining the axes that define the 3D space, with a direct influence on the position of the points observed in the experiment
Muonography of Caves of the Holy Dormition Pskovo-Pechersky Monastery
Authors: Alexandrov Andrey , Anokhina Anna , Vasina Svetlana , Gippius Alexei , Gorbunov Sergei , Grachev Victor , Konovalova Nina , Krasilnikova Yulia , Larionov Alexey , Managadze Alexander , Melnichenko Ilia , Okateva Natalia , Paramonov Sergey , Petrukhin Anatoly , Polukhina Natalia , Roganova Tatiana , Sadykov Zhakypbek , Starkov Nikolay , Starkova Elena , Tioukov Valeri , Chernyavskii Mikhail , Shevchenko Vladimir , Shchedrina Tatiana
Published: September 2023

The results of muonographic study of two objects in the cave complex of the unique historical and archaeological memorial, the Holy Dormition Pskovo-Pechersky Monastery, are presented. The experimental technology is based on the use of nuclear emulsion detectors.
SSR Based Genetic Diversity Analysis and Population Structure of Proso millet (Panicum miliaceum L.) in Kazakhstan
Authors: Zargar Meisam , Dyussibayeva Elmira , Orazov Aidyn , Zeinullina Aiym , Zhirnova Irina , Yessenbekova Gulzat , Rysbekova Aiman
Published: September 2023

Proso millet is an important allotetraploid cereal crop, however, it is the least studied species of the Poaceae family as it is an under-utilized crop. Genomic resources of proso millet are very limited compared to the major crops. Understanding of genetic relationships among germplasm resources is important for future breeding endeavors. In the present study, the SSR markers were employed to assess the polymorphism and genetic diversity of 100 millet accessions from different countries, which were tested in the dry steppe zone conditions of the Akmola region from 2020 to 2022. The use of 20 SSR markers detected a total of 47 alleles with an average allele number of 2.35 per locus among these proso accessions. Nine of them were polymorphic among genotypes, which suggests that these SSR markers can be used for genetic studies. The results showed a moderate level of polymorphism information content (PIC) averaged at 0.424, ranging from 0.125 to 0.795. The markers SSR 67, SSR-82, SSR-85 and SSR-109 showed high PIC values, 0.536, 0.756, 0.795 and 0.758 respectively. Markers SSR 85 and SSR 86 significantly correlated to agronomic traits, such as productive tillering (PT) and grain yield (GY). The genetic structure, UPGMA cluster and PCoA assay indicated that the accessions originated from Central Asia had higher genetic diversity. Based on Structure (K=3), all the accessions were divided into three groups, whereas the gene pool originated from Central Asia were detected in all the three clusters. Based on principal component analysis (PCA), the accessions of Central Asian origin were genetically closer to the North Asian group.
What Am I Doing for (Their) a Living? Positive Impact and Innovative Behavior at Work: The Mediating Role of Needs Satisfaction
Authors: Papachristopoulos Konstantinos , Gradito Dupord Marc Antoine , Jauvin Florence , Forest Jacques , Coulombe Patrick
Published: September 2023

In recent research, a growing body of empirical evidence, suggests that prosocial impact at work can play a significant role in enhancing creativity and innovativeness. Drawing from Self Determination Theory, we hypothesized that basic psychological needs and benevolence satisfaction could serve as a mediating factor in the relation between employees perceived social impact and innovative work behavior and creativity, thus illuminating the manner in which contentment of psychological needs fosters inventive proclivities within the organizational milieu. Results from a study in Greece and Canada (N=528) showed that both perceived social impact and prosocial motivation are positively associated with innovative work behavior and creativity while autonomy and competence satisfaction mediate the relation between perceived social impact and the work outcomes examined within this study. Moreover, prosocial motivation was found to moderate the relation between benevolence satisfaction and innovativeness. Findings extend prior research on the role of prosociality on creative behavior at work and provide supporting evidence for the organizations that encourage and support employees’ initiatives to make a positive difference in the lives of others.
A Geoethics Syllabus for Higher Education: Evaluation of an Intervention Programme
Authors: Vasconcelos Clara , Cardoso Alexandra , Ribeiro Tiago
Published: September 2023

Geoethics is a field of knowledge currently in full development. Researchers in geoethics are pri-marily concerned with the anthropogenic interaction with the Earth system. Due to its nature, ge-oethics holds particular importance in sustainable development due to its nature as it aims to promote ethical human behaviour that does not negatively impact the Earth system. In the present research, we implemented an intervention program addressing various issues related to the sus-tainability of the Earth system, such as the exploitation of geological resources, the management of geological risks, and the conservation and promotion of geopatrimony. The intervention program was applied to higher education students in the geosciences field. A sample of 90 students from various geosciences courses completed an initial questionnaire, revealing limited knowledge about geoethics. This study resorted to mixed-method research involving interviews with some students who volunteered (n=52). The results showed that after applying the intervention programme most students had developed a deeper understanding of the topics addressed and recognised the con-tributions this scientific area can make to sustainable development. Additional research in geoethics education is essential to foster the integration of geoethics into the curricula of higher education institutions.
Current Data and Future Perspectives on Patients with Atrial Fibrillation and Cancer
Authors: De Luca Leonardo , Camilli Massimiliano , Canale Maria Laura , Mistrulli Raffaella , Andreoli Federico , Giacalone Guido , Turazza Fabio Maria , Gabrielli Domenico , Bisceglia Irma
Published: September 2023

Atrial fibrillation (AF) is an increasingly recognized comorbidity in patients with can-cer. Indeed, cancer patients have a significantly higher incidence of AF than that ob-served in the general population. A reciprocal relationship between these two diseases has been observed, as much as some assume AF as a marker for occult cancer screen-ing, especially in older adults. The pathophysiological mechanisms are many and var-ied, including the underlying pro-inflammatory state, specific treatments (chemo and radiotherapy) and surgery. The therapeutic management of patients with cancer and AF involves the same rhythm and frequency control strategies as the general popula-tion; however, the numerous interactions with chemotherapeutics, which lead to a sig-nificant increase in side effects, as well as the extreme fragility of the patient should be considered. Anticoagulant therapy is also a complex challenge to address, as bleeding and stroke risk scores have not been fully assessed in this subpopulation. Furthermore, in large studies establishing the efficacy of direct oral anticoagulants (DOACs), cancer patients have been underrepresented. In this review, we elaborate on mechanisms linking AF to cancer patients with a particular focus on therapeutic challenges in this population.
Hydrological Response Assessment of Land Cover Change in a Peruvian Amazonian Basin Impacted by Deforestation Using the SWAT Model
Authors: Paiva Karla , Rau Pedro , Montesinos Cristian , Lavado-Casimiro Waldo , Bourrel Luc , Frappart Frederic
Published: September 2023

The watershed hydrologic conditions in the Madre de Dios (MDD) basin in the Peruvian Amazon have been irreversibly impacted by deforestation and changes in land use cover. These changes have also had detrimental effects on the geomorphology, water quality, and aquatic habitat within the basin. However, there is a scarcity of hydrological modeling studies in this area primarily due to the limited availability of hydrometeorological data. The primary objective of this study was to examine how deforestation impacts the hydrological conditions in the MDD basin. By implementing the Soil and Water Assessment Tool (SWAT) model, this study determined that replacing 12% of the evergreen broadleaf forest area with bare land resulted in an significant increase in surface runoff by 38% monthly, a reduction of evapotranspiration by 1% annually, and an average monthly streamflow increase of 12%. Changes in spatial patterns reveal that the primary impacted watershed is the Inambari River subbasin, a significant tributary of the Madre de Dios River. This area experiences an annual average surge of 187% in surface runoff generation while witnessing an annual average reduction of 8% in evapotranspiration.These findings have important implications, as they can contribute to instances of flooding and extreme inundation events, which have already occurred in the MDD region.
Factors Associated with Humoral Immune Response Following the Third Dose of the BNT162b2 Received by Employees at a Health–Care Facility
Authors: Palacka Patrik , Svobodová Alena , Skokanová Lucia , Obertová Jana , Rejleková Katarína , Babeľa Róbert , Mego Michal , Vulganová Martina , Pechan Juraj
Published: September 2023

Background: BNT162b2 represents the authorized mRNA vaccine against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS–CoV–2) causing Covid–19. Methods: We conducted a prospective, single–center observational study with 273 employees of a medical facility to determine the efficacy and safety of the BNT162b2 third dose in relation to sex and BMI, and explore the possible determinants of neutralizing IgG and 25–hydroxy (25–OH) vitamin D levels. Results: At the median follow–up of 4.7 months, 38 of the participants had Covid–19 following vaccination. The incidence of adverse events (AEs) was significantly higher in females vs. males (p < 0.0108) and subjects with a high BMI of ≥ 30 kg/m2 vs. low BMI (p < 0.0117). The values of IgG were significantly enhanced in males vs. females (p < 0.0004), participants with high BMI vs. low BMI (p < 0.0003), a high number of ≥3 AEs vs. low number of AEs (p < 0.0003), and following infection with Covid–19 vs. without Covid–19 (p < 0.0005). Multivariate analysis (MVA) showed sex, BMI, number of AEs, and Covid-19 to be of predictive significance. On the contrary, 25–OH vitamin D concentrations in individuals with high vs. low BMI were significantly reduced (p < 0.0144) but this was not evident in MVA. Conclusions: This study confirmed the high efficacy of BNT162b2 in real–world scenario and revealed that its safety was affected by sex and BMI. Higher IgG levels suggesting better protection against infection were present in males, participants with high BMI, a high frequency of AEs, and those who overcame Covid-19 following vaccination.
Expression of IFITM1 and IFITM3 Proteins Inhibits Infectivity of Progeny HIV-1 by Distinct Mechanisms
Authors: Verma Smita , Chen Yen-Cheng , Marin Mariana , Gillespie Scott E. , Melikyan Gregory B.
Published: September 2023

The human interferon-induced transmembrane (IFITM) proteins inhibit the fusion of a broad spectrum of enveloped viruses, both when expressed in target cells and when present in infected cells. Upon expression in infected cells, IFITMs incorporate into progeny virions and reduce their infectivity by a poorly understood mechanism. Since only a few Env glycoproteins are present on HIV-1 particles, and Env clustering has been proposed to be essential for optimal infectivity, we asked if IFITM protein incorporation modulates HIV-1 Env clustering. The incorporation of two members of the IFITM family, IFITM1 and IFITM3, into HIV-1 pseudoviruses verified by Western blotting correlated with a marked reduction of infectivity. Super-resolution imaging of Env distribution on single HIV-1 pseudoviruses did not reveal significant effects of IFITMs on Env clustering. However, IFITM3 markedly reduced the Env processing and incorporation into virions relative to control and IFITM1-containing viruses. These results suggest that IFITM1 and IFITM3 restrict progeny HIV-1 infectivity via distinct mechanisms. We propose that IFITM1 interferes with viral fusion by altering the properties of the viral membrane or Env functionality by means other than disrupting Env clusters, while IFITM3 also targets Env processing and incorporation into progeny virions.
Linking Migraine to Gut Dysbiosis And Chronic Non-Communicable Diseases
Authors: Di Lauro Manuela , Guerriero Cristina , Cornali Kevin , Albanese Maria , Costacurta Micaela , Mercuri Nicola Biagio , Di Daniele Nicola , Noce Annalisa
Published: September 2023

In the world, migraine is one of the most common cause of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers, in combination with a genetic predisposition. Among factors related to the migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut-brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this contest, in addition to migraine conventional pharmacological treatments, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, like diabetes mellitus, arterial hypertension, obesity, cancer and chronic kidney diseases, whose link is represented by gut dysbiosis.
Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies
Authors: Zarrabi Ali , Perrin David , Kavoosi Mahboubeh , Sommer Micah , Sezen Serap , Mehrbod Parvaneh , Bhushan Bhavya , Machaj Filip , Rosik Jakub , Kawalec Philip , Afifi Saba , Bolandi Seyed Mohammadreza , Koleini Peyman , Taheri Mohsen , Madrakian Tayyebeh , Łos Marek Jan , Lindsey Benjamin , Cakir Nilufer , Zarepour Atefeh , Hushmandi Kiavash , Fallah Ali , Koc Bahattin , Ahmadi Mazaher , Logue Susan E. , Orive Gorka , Pecic Stevan , Gordon Joseph W. , Ghavami Saeid
Published: September 2023

Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models, and in vitro 3-dimensional bioengineering models of Rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration.
A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)
Authors: Ambade Shraddha , Gupta Vivek Kumar , Bhole RItesh P , Khedekar Pramod B , Chikhale Rupesh V
Published: September 2023

Staphylococcus aureus is a common pathogen in human. Methicillin resistant Staphylococcus aureus (MRSA) infection poses a big and perplexing difficulty in terms of therapy. The acquisition of the non-native gene PBP2a, which has a decreased tolerance for β-lactam antibiotics, frequently confers resistance. PBP2a has a less attraction for methicillin and it helps bacteria to continue peptidoglycan biosynthesis, and it is cell wall’s core component in bacteria. So, even in the presence of methicillin or any other antibiotic, bacteria develop resistance. Due to resistance-causing genes, S. aureus becomes MRSA. The main premise of the resistance mechanism is well understood. The current demand for novel antibiotics is legitimate in the face of therapeutic concerns posed by resistant micro-organisms. The emphasis of this review is on PBP2a scaffolds and the different screening approaches used to find PBP2a inhibitors. Penicillin, Cephalosporins, Pyrazole-Benzimidazole based derivatives, Oxadiazole containing derivatives, non-β-lactam allosteric inhibitors, 4-(3H)-Quinazolinones, Pyrrolylated chalcone, Bis-2-Oxoazetidinyl macrocycle (β-lactam antibiotics with 1, 3-Bridges), Macrocycle-embedded β-lactams as novel inhibitors, Pyridine-Coupled Pyrimidinones, novel Naphthalimide corbelled aminothiazoximes, non-covalent inhibitors, Investigational-β-lactam antibiotics Carbapenem, novel Benzoxazole derivatives, Pyrazolylpyridine analogues, and other miscellaneous classes of scaffolds for PBP2a are also represented as well as with their biological activity is discussed. The penicillin-binding protein is also discussed, which is the crucial target for the cell wall of MRSA. Various aspects of PBP2a, the cell wall of bacteria, peptidoglycans, different crystal structures of PBP2a, synthetic routes for PBP2a inhibitors, and future perspectives of MRSA inhibitors are also enumerated.
Control of Contamination in Fresh Vegetables Using Optical Inactivation of Microorganisms: A Mathematically Analyzed Experiment
Authors: Oliveira Bruno Pereira de , Blanco Kate Cristina , Yasuoka Fátima Maria Mitsue , De Castro Neto Jarbas Caiado , Bagnato Vanderlei Salvador
Published: September 2023

Cross-contamination poses a pervasive challenge within the realm of food production. The propagation of infections is recognized to occur in an uncontrolled manner. Given the essential nature of food for human sustenance, the domain necessitates stringent control over contamination and cross-contamination due to the perilous potential for severe intoxication. In the context of managing biological contamination in fresh food items, commencing from production and extending to the final consumable, the utilization of chemicals must be judiciously limited to avert adverse effects. This biochemical approach, however, engenders environmental and health quandaries attributable to the incessant employment and discharge of such materials. The present research is centered upon demonstrating, at a laboratory scale, a process involving the leaching of plants, accompanied by the application of UVC irradiation during this procedure. This obviates the necessity for chemical solutions. The empirical findings showcased that subjecting the solution utilized for vegetable washing to UV irradiation rendered it 99 % microorganism-free in vegetables and 99.999% in the water component. This attests to efficacious decontamination, resource conservation, and mitigation of discharge-associated predicaments. The mathematical model precisely characterizes the behaviors manifested in the empirical data, thereby establishing a close correspondence with the kinetics law equation. Grasping the fundamental mechanisms and articulating them enables the enhancement of optimization and seamless integration of this approach to combat cross-contamination with heightened efficacy. This approach to addressing cross-contamination holds significant promise, underscoring its pivotal role in elevating food safety measures and ameliorating environmental repercussions. Envisioning the implementation of these practices at an industrial scale carries the potential to yield substantial dividends in terms of public health and sustainable practices
An Order-Theoretic Study on Formal Concept Analysis
Authors: Syau Yu-Ru , Lin En-Bing , Liau Churn-Jung
Published: September 2023

In this paper, we study properties of formal concepts from an order-theoretic perspective. We first establish a natural correspondence between formal contexts and preorders as well as their induced posets. Then, based on the poset induced from a formal context, we provide characterization for join-irreducible or meet-irreducible elements of finite concept lattices. In addition, we introduce the notion of rough conceptual approximations based on topological closure and interior operators. In contrast with the conventional definition of equivalence class of an object used in Pawlakian approximation spaces, we instead utilize the extent of an object concept. We show that rough conceptual approximations are equivalent to approximation operators in the generalized approximation space associated with the preorder corresponding to a formal context. We also illustrate these theoretical results with examples and discuss their potential applications.
Novel Hydrogel Sodium Alginate Edible Active Coatings Development Rich in Thymol@halloysite. Application on “Tsalafouti” Traditional Greek Cheese Preservation Process
Authors: Giannakas Aris E. , Zaharioudakis Konstantinos , Kollia Eleni , Kopsacheili Anna , Avdylaj Learda , Georgopoulos Stavros , Leontiou Areti , Karabagias Vassilios K. , Kehayias George , Ragkava Efthymia , Proestos Charalampos , Salmas Constantinos E
Published: September 2023

The necessity to reduce the effect of the greenhouse phenomenon imposed the turn of the food packaging technology to the use of biobased raw materials decreasing the carbon dioxide fingerprint. In this direction alginates derived from brown algae species are of the most promising biobased biopolymers, used for development of edible active coatings, capable to protect food from oxidation/bacterial spoilage. In this study sodium alginate, which was plasticized with glycerol and mixed with a biobased thymol/natural halloysite nanohybrid, was used to develop novel edible active coatings. Active nanocomposite coatings developed by mixing of pure halloysite with sodium alginate/glycerol matrix were produced for comparison purposes. X-Ray and Fourier Transform Infrared Spectroscopy indicated higher compatibility of thymol/halloysite nanohybrid with sodium alginate/glycerol matrix compared to the relevant of pure halloysite. This increased compatibility led to higher tensile properties, water/oxygen barrier properties, and total antioxidant activity. All coating samples were applied as edible active coatings for “tsalafouti” spreadable soft cheese, exhibited a reduction of mesophilic microbial population of more than one log10(cfu/g) unit comparing with uncoated cheese. Moreover, the reduction of mesophilic microbial population was increased by increasing halloysite and thymol content which indicates the sodium alginate/glycerol/thymol/halloysite as promising edible active coatings for “tsalafouti”.
New Advances of Nano-Enabled Weed Management: Using Poly(Epsilon-Caprolactone)-Based Nanoherbicides—A Review
Authors: Zargar Meisam , Bayat Maryam , Saquee Francess Sia , Diakite Simbo , Ramzanovich Nakhaev M , Akhmadovich Khasukhadzhiev A.S
Published: September 2023

New advances of nano-enabled weed management: using poly(epsilon-caprolactone)-based nanoherbicides. A review
Analisis Livelihood Strategy Masyarakat Suku Baduy pada Masa Pandemi Covid-19
Authors: Prabowo Andi , Syakirah Bella , Azura A.A. Diva , Azura A.A. Diva , Putri Nadia
Published: September 2023

Livelihood Strategy merupakan kegiatan atau upaya untuk dapat memenuhi kebutuhanhidup. Tulisan ini dimaksudkan untuk menjelaskan terkait strategi pemenuhan kebutuhanhidup (Livelihood Strategy) masyarakat Kampung Gajeboh. Kampung Gajeboh merupakansalah satu kampung yang berada di Desa Kanekes, Kecamatan Leuwidamar, Kab. Lebak,Banten. Penelitian ini bertujuan untuk mengetahui penerapan Livelihood Strategy diKampung Gajeboh yang terdiri dari kondisi kehidupan masyarakat Kampung Gajebohselama pandemi Covid-19, penerapan Livelihood Strategy masyarakat Kampung Gajeboh,dan mekanisme Livelihood Strategy masyarakat Kampung Gajeboh. Penelitian ini dilakukanpada tanggal 5-7 November 2021 pada kegiatan Field Trip di Kampung Gajeboh, DesaKanekes, Kecamatan Leuwidamar, Kab. Lebak, Banten. Dalam penelitian ini, penelitimenggunakan metode penelitian deskriptif kualitatif. Pengumpulan data menggunakan teknikinteraktif yang terdiri dari wawancara mendalam, observasi berperan, dan dokumentasidengan empat narasumber mengenai penerapan Livelihood Strategy di Kampung Gajeboh,Desa Kanekes, Kecamatan Leuwidamar, Kab. Lebak, Banten. Data dianalisis menggunakantiga alur aktivitas dalam analisis data interaktif yaitu data reduction (redaksi data), datadisplay (penyajian data), conclusion drawing/verification. Pandemi Covid-19 memberikandampak negatif terhadap bidang ekonomi masyarakat Kampung Gajeboh Baduy dalamproses mekanisme pasar dan penurunan kunjungan wisatawan. Namun, pada kehidupansehari-hari terutama dalam hal pemenuhan kebutuhan tidak berdampak secara signifikan.Masyarakat Kampung Gajeboh Baduy menerapkan Livelihood Strategy denganmemanfaatkan lima modal yang terdiri dari modal manusia (Human Capital), modal alam(Natural Capital), modal keuangan (Financial Capital), modal sosial (Social Capital), danmodal fisik (Physical Capital). konstruksi dari penerapan lima modal sosial menjadikontributor berlangsungnya mekanisme livelihood Strategy yaitu intensifikasi, ekstensifikasi,diversifikasi, dan rekayasa spasial. Keempat model tersebut menjadi indikator penerapanstrategi “Farm” yang terdiri dari strategi “On-Farm” dari penggabungan intensifikasi danekstensifikasi, serta strategi “Non-Farm” dari penggabungan diversifikasi dan rekayasaspasial.