bluuebunny/crossref_metadata_2025 huggingface dataset:
The regulatory factor SipA is a highly stable β‐II class protein with a SH3 fold
Authors: López-Redondo María Luisa , Contreras Asunción , Marina Alberto , Neira José L.
Published: January 2010

The small regulator SipA, interacts with the ATP‐binding domain of non‐bleaching sensor histidine kinase (NblS), the most conserved histidine kinase in cyanobacteria. NblS regulates photosynthesis and acclimation to a variety of environmental conditions. We show here that SipA is a highly stable protein in a wide pH range, with a thermal denaturation midpoint of 345 K. Circular dichroism and 1D1H NMR spectroscopies, as well as modelling, suggest that SipA is a β‐II class protein, with short strands followed by turns and long random‐coil polypeptide patches, matching the SH3 fold. The experimentally determinedm‐value and the heat capacity change upon thermal unfolding (ΔCp) closely agreed with the corresponding theoretical values predicted from the structural model, further supporting its accuracy.
Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of l‐carnitine supplementation
Authors: Ribas Graziela S. , Manfredini Vanusa , de Mari Jurema F. , Wayhs Carlos Y. , Vanzin Camila S. , Biancini Giovana B. , Sitta Angela , Deon Marion , Wajner Moacir , Vargas Carmen R.
Published: January 2010

Disorders of propionate metabolism are autosomal recessive diseases clinically characterized by acute metabolic crises in the neonatal period and long‐term neurological deficits whose pathophysiology is not completely established. There are increasing evidences demonstrating antioxidant properties for l‐carnitine, which is used in the treatment of propionic and methylmalonic acidemias to increase the excretion of organic acids accumulated in tissues and biological fluids of the affected patients. In this work we aimed to evaluate lipid (malondialdehyde content) and protein (carbonyl formation and sulfhydryl oxidation) oxidative damage in plasma from patients with propionic and methylmalonic acidemias at the moment of diagnosis and during treatment with l‐carnitine. We also correlated the parameters of oxidative damage with plasma total, free and esterified l‐carnitine levels. We found a significant increase of malondialdehyde and carbonyl groups, as well as a reduction of sulfhydryl groups in plasma of these patients at diagnosis compared to controls. Furthermore, patients under treatment presented a marked reduction of the content of protein carbonyl groups, similar to controls, and malondialdehyde content in relation to patients at diagnosis. In addition, plasma total and free l‐carnitine concentrations were negatively correlated with malondialdehyde levels. Taken together, the present data indicate that treatment significantly reduces oxidative damage in patients affected by disorders of propionate metabolism and that l‐carnitine supplementation may be involved in this protection.
Pharmacokinetics of Amantadine in Children With Impaired Consciousness due to Acquired Brain Injury: Preliminary Findings Using a Sparse‐sampling Technique
Authors: Vargus‐Adams Jilda N. , McMahon Mary A. , Michaud Linda J. , Bean Judy , Vinks Alexander A.
Published: January 2010

Objective

To evaluate the pharmacokinetics of amantadine in children with impaired consciousness from acquired brain injury.

Design

Randomized, double‐blind, placebo‐controlled, crossover study with sparse sampling for pharmacokinetics.

Setting

Tertiary care pediatric hospital.

Participants

Children, ages 6‐18 years, with impaired consciousness 5‐10 weeks after acquired brain injury.

Methods

Subjects received amantadine for 3 weeks. Subjects were randomized to placebo or amantadine 4 mg/kg/day for 7 days followed by 6 mg/kg/day for 14 days. Crossover was after a 7‐day washout period.

Main Outcome Measures

The Coma/Near‐Coma Scale and Coma Recovery Scale‐Revised were done 3 times per week to evaluate arousal and consciousness. Plasma concentrations of amantadine were determined for pharmacokinetic parameter estimation and evaluation of the exposure‐response relationship. Adverse events were monitored.

Results

Nine subjects met the final inclusion and exclusion criteria, 7 of whom agreed to participate. Five subjects completed both arms of the study. Amantadine total body clearance was 0.17 L/h/kg with a half‐life of 13.9 hours. Higher exposure of amantadine (average concentration of amantadine during 6 mg/kg/day > 1.5 mg/L) may be associated with better recovery of consciousness.

Conclusions

Amantadine was well‐tolerated in children with acquired brain injury and demonstrates pharmacokinetics similar to those reported for healthy young adults. Based on the preliminary data, higher dosing may be considered in the setting of brain injury.
The Cambridge Introduction to Jean Rhys
Authors: Savory Elaine
Published: January 2010

Since her death in 1979, Jean Rhys's reputation as an important modernist author has grown. Her finely crafted prose fiction lends itself to multiple interpretations from radically different critical perspectives; formalism, feminism, and postcolonial studies among them. This Introduction offers a reliable and stimulating account of her life, work, contexts and critical reception. Her masterpiece, Wide Sargasso Sea, is analyzed together with her other novels, including Quartet and After Leaving Mr Mackenzie, and her short stories. Through close readings of the works, Elaine Savory reveals their common themes and connects these to different critical approaches. The book maps Rhys's fictional use of the actual geography of Paris, London and the Caribbean, showing how key understanding her relationships with the metropolitan and colonial spheres is to reading her texts. In this invaluable introduction for students, Savory explains the significance of Rhys as a writer both in her lifetime and today.
Democratic Innovations
Authors: Smith Graham
Published: January 2010

Can we design institutions that increase and deepen citizen participation in the political decision making process? At a time when there is growing disillusionment with the institutions of advanced industrial democracies, there is also increasing interest in new ways of involving citizens in the political decisions that affect their lives. This book draws together evidence from a variety of democratic innovations from around the world, including participatory budgeting in Brazil, Citizens' Assemblies on Electoral Reform in Canada, direct legislation in California and Switzerland and emerging experiments in e-democracy. The book offers a rare systematic analysis of this diverse range of democratic innovations, drawing lessons for the future development of both democratic theory and practice.
Rights, Race, and Recognition
Authors: Darby Derrick
Published: January 2010

What is the source of rights? Rights have been grounded in divine agency, human nature, and morally justified claims, and have been used to assess the moral status of legal and customary social practices. The orthodoxy is that some of our rights are a species of unrecognized or natural rights. For example, black slaves in antebellum America were said to have such rights, and this was taken to provide a basis for establishing the immorality of slavery. Derrick Darby exposes the main shortcomings of the orthodox conception of the source of rights and proposes a radical alternative. He draws on the legacy of race and racism in the USA to argue that all rights are products of social recognition. This bold, lucid and meticulously argued book will inspire readers to rethink the central role assigned to rights in moral, political, and legal theory as well as in everyday evaluative discourse.
Plastid Biology
Authors: Pyke Kevin
Published: January 2010

Plastids reside in all plant cells, and take on different forms in relation to their cellular function, biochemistry and storage capacity. The modern era of molecular biology and molecular genetics has enabled much to be learnt about how plastids function, and how they relate to their evolutionary past. In this accessible text, Kevin Pyke expertly describes how the plastids are highly complex organelles at the very core of plant cellular function, providing final year undergraduate and graduate students with an overview of plastid biology and recent developments in the field. Topics covered include: a consideration of different plastid types and how they relate to cell function; plastid genomes and how proteins are imported into plastids; photosynthesis and core aspects of plastid biochemistry; plastid signalling and functionality within a cellular context; and plastid genetic manipulation. Supplementary colour images are available online at www.cambridge.org/9780521885010.
The Scramjet Engine
Authors: Segal Corin
Published: January 2010

The renewed interest in high-speed propulsion has led to increased activity in the development of the supersonic combustion ramjet engine for hypersonic flight applications. In the hypersonic regime the scramjet engine's specific thrust exceeds that of other propulsion systems. This book, written by a leading researcher, describes the processes and characteristics of the scramjet engine in a unified manner, reviewing both theoretical and experimental research. The focus is on the phenomena that dictate the thermo-aerodynamic processes encountered in the scramjet engine, including component analyses and flowpath considerations; fundamental theoretical topics related to internal flow with chemical reactions and non-equilibrium effects, high-temperature gas dynamics, and hypersonic effects are included. Cycle and component analyses are further described, followed by flowpath examination. Finally, the book reviews experimental and theoretical capabilities and describes ground testing facilities and computational fluid dynamics facilities developed for the study of time-accurate, high-temperature aerodynamics.
The Autonomy of Mathematical Knowledge
Authors: Franks Curtis
Published: January 2010

Most scholars think of David Hilbert's program as the most demanding and ideologically motivated attempt to provide a foundation for mathematics, and because they see technical obstacles in the way of realizing the program's goals, they regard it as a failure. Against this view, Curtis Franks argues that Hilbert's deepest and most central insight was that mathematical techniques and practices do not need grounding in any philosophical principles. He weaves together an original historical account, philosophical analysis, and his own development of the meta-mathematics of weak systems of arithmetic to show that the true philosophical significance of Hilbert's program is that it makes the autonomy of mathematics evident. The result is a vision of the early history of modern logic that highlights the rich interaction between its conceptual problems and technical development.
Understanding Labor and Employment Law in China
Authors: Brown Ronald C.
Published: January 2010

Continued economic prosperity in China and its international competitive advantage have been due in large part to the labor of workers in China, who for many years toiled in underregulated workplaces. More recently, labor law reforms have been praised for their progressive measures and, at the same time, blamed for placing too many economic burdens on companies, especially those operating on the margins, which in some cases have caused business failures. This, combined with the global downturn and the millions of displaced and unemployed Chinese migrant laborers, has created ongoing debate about the labor laws. Meanwhile, the Chinese Union has organized many of the Global Fortune 500 companies, and a form of collective bargaining is occurring. Workers are pursuing their legal labor rights in increasing numbers. This book provides a clear overview of the labor and employment law environment in China and its legal requirements, as well as practices under these laws used to deal with labor issues.
Visions of World Community
Authors: Bartelson Jens
Published: January 2010

Throughout the history of Western political thought, the creation of a world community has been seen as a way of overcoming discord between political communities without imposing sovereign authority from above. Jens Bartelson argues that a paradox lies at the centre of discussions of world community. The very same division of mankind into distinct peoples living in different places which makes the idea of a world community morally compelling has also been the main obstacle to its successful realization. His book offers a philosophical and historical analysis of the idea of world community by exploring the relationship between theories of world community and changing cosmological beliefs from the late Middle Ages to the present.
Economics and Marijuana
Authors: Clements Kenneth W. , Zhao Xueyan
Published: January 2010

Do marijuana users cut back on consumption when the price rises? To what degree is marijuana consumption related to drinking and tobacco usage? What would happen if marijuana were legalised and taxed in the same way as alcohol and tobacco? Is marijuana priced in a similar way to other goods? Economics and Marijuana deals with these and other questions by drawing on a rich set of data concerning the consumption and pricing of marijuana in Australia, a country where the drug has been decriminalised in some, but not all, states. The book applies the economic approach to drugs to analyse consumption, pricing and the economics of legalising the use of marijuana. The result is a fascinating analysis of this widely used, but little understood illicit drug that provides much needed information and policy advice for a wide range of readers, including economists, policy makers and health professionals.
Broad Bills or Particularistic Policy? Historical Patterns in American State Legislatures
Authors: GAMM GERALD , KOUSSER THAD
Published: January 2010

When do lawmakers craft broad policies, and when do they focus on narrow legislation tailored to a local interest? We investigate this question by exploring historical variation in the types of bills produced by American state legislatures. Drawing on a new database of 165,000 bills—covering sessions over 120 years in thirteen different states—we demonstrate the surprising prominence of particularistic bills affecting a specific legislator's district. We then develop and test a theory linking the goals of legislators to their propensity to introduce district bills rather than broad legislation. We find that, consistent with our predictions, politicians are more likely to craft policies targeted to a particular local interest when a legislature is dominated by one party or when it pays its members relatively high salaries. These findings provide empirical support for Key's (1949) thesis that one-party politics descends into factionalism and undermines the making of broad public policy.
Energy requirements of adult cats
Authors: Bermingham Emma N. , Thomas David G. , Morris Penelope J. , Hawthorne Amanda J.
Published: January 2010

A meta-analysis was carried out in order to establish the energy requirements of adult cats. Publications that identified cat body weight (BW) were used to generate allometric relationships between energy requirements and BW of healthy adult cats, using log-log linear regression. Energy requirements were expressed in kcal/kg BW to be consistent with those reported by the National Research Council. Mean maintenance energy requirements were 55·1 (se1·2) kcal/kg BW (115 treatment groups). Three allometric equations were identified to predict the energy requirements for maintenance of BW in the cat based on BW: light (53·7 kcal/kg BW− 1·061), normal (46·8 kcal/kg BW− 1·115) and heavy (131·8 kcal/kg BW− 0 ·366). When reported on lean mass, the allometric equation revealed maintenance requirements were 58·4 kcal/kg lean mass− 1·140(adjustedR20·694; thirty-six treatment groups). The present review suggests that values for maintenance energy requirements based on BW alone may not be an accurate prediction and more detailed information on the age, sex and neuter status, BW and composition would enhance the ability to interpret the maintenance energy requirements of cats.
Dietary assessment methods for micronutrient intake: a systematic review on vitamins
Authors: Henríquez-Sánchez Patricia , Sánchez-Villegas Almudena , Doreste-Alonso Jorge , Ortiz-Andrellucchi Adriana , Pfrimer Karina , Serra-Majem Lluis
Published: January 2010

The EURRECA Network of Excellence is working towards the development of aligned micronutrient recommendations across Europe. The purpose of the present study was to define how to identify dietary intake validation studies in adults pertaining to vitamins. After establishing a search strategy, we conducted a MEDLINE and EMBASE literature review. A scoring system was developed to rate the quality of each validation study according to sample size, statistical methods, data collection procedure, seasonality and vitamin supplement use. This produced a quality index with possible scores obtained ranging from 0·5 to 7. Five thousand four-hundred and seventy-six papers were identified. The numbers meeting the inclusion criteria were: for vitamin A, 76; vitamin C, 108; vitamin D, 21; vitamin E, 75; folic acid, 47; vitamin B12, 19; vitamin B6, 21; thiamine, 49; riboflavin, 49; and niacin, 32. The most frequently used method to ascertain dietary intake was the Food Frequency Questionnaire (FFQ), whereas dietary records (DR) and 24-h recalls were the most used reference methods. The correlation coefficients (CC) between vitamin intakes estimated by FFQ and the reference method were weighted according to the study's quality index and ranged from 0·41 to 0·53 when the reference method was the DR and from 0·43 to 0·67 when the reference was 24-h recalls. A minority of studies (n33) used biomarkers for validation and in these the CC ranged from 0·26 to 0·38. The FFQ is an acceptable method of assessing vitamin intake. The present review provides new insights regarding the characteristics that assessment methods for dietary intake should fulfil.
Dietary assessment methods on n-3 fatty acid intake: a systematic review
Authors: Øverby Nina C. , Serra-Majem Lluis , Andersen Lene Frost
Published: January 2010

In order to assess nutritional adequacy, valid estimates of nutrient intake are required. Specifically, the EURopean micronutrient RECommendations Aligned (EURRECA) Network of Excellence needs clear guidelines for assessing the validity of reported micronutrient intakes and n-3 fatty acid (FA) intakes. The aim of the present study was to review the validity of methods used to measure the usual n-3 FA intake of a population. A systematic literature search was conducted for studies validating the methodology used for measuring the dietary intake of n-3 FA. The quality of the validation studies and the quality of the different dietary assessment methods were assessed using scoring systems developed by EURRECA. Fourteen papers, describing twenty studies, were identified for inclusion. According to the score system developed by EURRECA, all the studies were ranked as average, except two that were ranked as poor. The correlation coefficients between FA in subcutaneous fat and dietary intake of n-3 FA from four FFQ, one weighed record and one 24-h recall ranged between 0·40 and 0·60. Correlations between intake of n-3 FA from five FFQ, one dietary history and three weighed records and blood lipids were similar to the ones observed for subcutaneous fat. The summarised quality of the n-3 FA estimates derived from the FFQ was judged as good or acceptable according to the EURRECA scoring system. The literature describes subcutaneous fat as the best reference method, and the studies where this was used had moderate correlation coefficients and no dietary intake method was superior to any other.
Dietary assessment methods for micronutrient intake in elderly people: a systematic review
Authors: Ortiz-Andrellucchi Adriana , Sánchez-Villegas Almudena , Doreste-Alonso Jorge , de Vries Jeanne , de Groot Lisette , Serra-Majem Lluís
Published: January 2010

The European micronutrient recommendations aligned (EURRECA) Network of Excellence seeks to establish clear guidelines for assessing the validity of reported micronutrient intakes among vulnerable population groups. A systematic literature review identified studies validating the methodology used in elderly people for measuring usual dietary micronutrient intake. The quality of each validation study selected was assessed using a EURRECA-developed scoring system. The validation studies were categorised according to whether the reference method applied reflected short-term intake ( < 7 d), long-term intake ( ≥ 7 d) or used biomarkers (BM). A correlation coefficient for each micronutrient was calculated from the mean of the correlation coefficients from each study weighted by the quality of the study. Thirty-three papers were selected, which included the validation of twenty-five different FFQ, six diet histories (DH), one 24-h recall (24HR) and a videotaped dietary assessment method. A total of five publications analysed BM, which were used to validate four FFQ, and one 24HR, presenting very good correlations only for vitamin E. The analysis of weighted correlation coefficients classified by FFQ or DH showed that most of the micronutrients had higher correlations when the DH was used as the dietary method. Comparing only FFQ results showed very good correlations for measuring short-term intakes of riboflavin and thiamin and long-term intakes of P and Mg. When frequency methods are used for assessing micronutrient intake, the inclusion of dietary supplements improves their reliability for most micronutrients.
Glycaemic index of Indian flatbreads (rotis) prepared using whole wheat flour and ‘atta mix’-added whole wheat flour
Authors: Radhika Ganesan , Sumathi Chandhrasekar , Ganesan Anbazhagan , Sudha Vasudevan , Jeya Kumar Henry Christiani , Mohan Viswanathan
Published: January 2010

To compare the glycaemic index (GI) of newly developed ‘atta mix’ roti with whole wheat flour roti. Eighteen healthy non-diabetic subjects consumed 50 g available carbohydrate portions of a reference food (glucose) and two test foods (whole wheat flour roti and atta mix roti) in random order after an overnight fast. The reference food was tested on three separate occasions, while the test foods were each tested once. Capillary blood samples were measured from finger-prick samples in fasted subjects ( − 5 and 0 min) and at 15, 30, 45, 60, 90 and 120 min from the start of each food. No significant difference was observed between roti prepared from whole wheat flour and atta mix in terms of appearance, texture, flavour, taste or acceptability. For each test food, the incremental area under the curve and GI values were determined. The GI of atta mix roti (27·3 (sem2·2)) was considerably lower than the whole wheat flour roti (45·1 (sem3·5),P < 0·001). Development of foods with lower dietary glycaemic load such as the atta mix roti could help in the prevention and control of diabetes in South Asian populations, which habitually consume very high glycaemic load diets.
The effects of probiotic and conventional yoghurt on lipid profile in women
Authors: Sadrzadeh-Yeganeh Haleh , Elmadfa Ibrahim , Djazayery Abolghasem , Jalali Mahmoud , Heshmat Ramin , Chamary Maryam
Published: January 2010

Many studies have been done on the hypocholesterolaemic effect of probiotic yoghurt. The results, however, are not conclusive. The aim of the present study was to test the effect of probiotic and conventional yoghurt on the lipid profile in women. In a randomised trial, ninety female volunteers aged 19–49 years were assigned to three groups. Subjects consumed daily 300 g probiotic yoghurt containingLactobacillus acidophilusLa5 andBifidobacterium lactisBb12 or 300 g conventional yoghurt or no yoghurt for 6 weeks. Fasting blood samples, 3 d dietary records and anthropometric measurements were collected at baseline (T1), end of week 3 (T2) and end of week 6 (T3). Lipid profile parameters were determined by enzymic methods. Results showed no significant difference in lipid profile within any group throughout the study. Comparing mean differences (T1 − T3) among the three groups showed: no difference in TAG and LDL-cholesterol, a decrease in cholesterol in both conventional (P < 0·05) and probiotic yoghurt groups (P < 0·005) compared with the control group, a decrease in total:HDL-cholesterol ratio for conventional (P < 0·05) and probiotic yoghurt groups (P < 0·001) compared with the control group, and an increase in HDL-cholesterol in the probiotic yoghurt group (P < 0·05) compared with the control group. Positive changes in lipid profile were observed in both yoghurt groups. Any added effect, therefore, is due to the consumption of fermented milk products.
The New Life Movement in Jiangxi Province, 1934–1938
Authors: FERLANTI FEDERICA
Published: January 2010

This paper discusses the origins and the implementation of the New Life Movement (NLM) in the Jiangxi Province between 1934 and 1938. Based upon primary sources produced during this period, it explores how the Nationalist Party utilised the NLM for the purposes of national reconstruction and social mobilisation. The first section analyses how elements of anti-communism, Christianity and state Confucianism came into play in the NLM; the second section analyses how the Nationalists reinforced the idea of ‘hygienic modernity’ by projecting it into the realms of state building and mass mobilisation; the third section discusses the changes introduced in society by the Nationalists with the creation of semi-governmental organisations; and the fourth section examines the involvement of the NLM with preparation for the war against Japan (1937–1945). The paper argues that the NLM had a lasting impact on Chinese society, and it contributed to shape citizenship and national identity.
Music education – a personal matter? Examining the current discourses of music education in Sweden
Authors: Georgii-Hemming Eva , Westvall Maria
Published: January 2010

The embedding of informal practices in music education in school relates to significant issues concerning students' engagement, participation, inclusion and the role of the teacher. This article addresses these issues by presenting and discussing current music education in compulsory comprehensive schooling in Sweden. It does so by drawing upon music pedagogical research, music education studies conducted during the last 10 years and national evaluations. Examples of practice from upper secondary schools are also used to clarify and illustrate the issues under consideration. It has been said that Swedish music education has gone from ‘School Music’ to ‘Music in School’. This development has been characterised by greater influence of students on curriculum content resulting in increased use of popular music, and, consequently, teaching strategies acquired from informal music playing contexts. The curriculum states that the core of the subject is practical music playing, through which personal development can occur – both musically and socially. Music education in several other countries is developing a more practical approach, and the role of popular music in schools, and what is sometimes called informal learning, is featured in international music pedagogy debates. This article considers the musical, pedagogical and democratic consequences of this pedagogy from a Swedish perspective. As a result of a sharp focus on personal social development and individual students' musical interests, music education in Sweden has become relatively limited in terms of repertoire, content and teaching methods. Recent evaluations and studies also demonstrate that music education lacks direction, and is short of creative engagement with music. The role of the teacher is unclear and sometimes lacks validity in a practical music education situation. Viewed from an international perspective, the kind of music education that has developed in Sweden is unique. Thus, when the possibilities and limitations of music education in Sweden are discussed, it has the potential to be of interest to international music education research.
Response
Authors: Green Lucy
Published: January 2010

I am grateful to Ruth Wright and the editors of the journal for inviting me to make this brief response to the fascinating set of articles collected here. Taking the articles as a whole, I wish to offer a few thoughts which came to mind whilst reading them, concerning our roles as music-education researchers and music educators in relation to informal learning.
Early Numerical Analysis in Kepler's New Astronomy
Authors: Thorvaldsen Steinar
Published: January 2010

Argument

Johannes Kepler published hisAstronomia novain 1609, based upon a huge amount of computations. The aim of this paper is to show that Kepler's new astronomy was grounded on methods from numerical analysis. In his research he applied and improved methods that required iterative calculations, and he developed precompiled mathematical tables to solve the problems, including a transcendental equation. Kepler was aware of the shortcomings of his novel methods, and called for a new Apollonius to offer a formal mathematical deduction. He was also in great need of computational power, and his friend and colleague, Wilhelm Schickard, constructed the first prototype of a true mechanical calculator, although it never came into regular use. The article concludes that Kepler's new astronomy was clearly backed up by numerical methods and embedded concepts and challenges of great importance for the future development of numerical analysis.
A Social History of the “Galois Affair” at the Paris Academy of Sciences (1831)
Authors: Ehrhardt Caroline
Published: January 2010

Argument

This article offers a social history of the “Galois Affair,” which arose in 1831 when the French Academy of Sciences decided to reject a paper presented by an aspiring mathematician, Évariste Galois. In order to historicize the meaning of Galois's work at the time he tried to earn recognition for his research on the algebraic solution of equations, this paper explores two interrelated questions. First, it analyzes scholarly algebraic practices and the way mathematicians were trained in the nineteenth century to reconstruct the scientific meaning of Galois's research. By emphasizing the historically contingent nature of scientific debates, the paper argues that to historicize the work of a mathematician, we must historicize the scientific world as well. The second part of this article goes further to seek a fresh perspective on Galois's short career by analyzing the cultural, social, and institutional dynamics that governed how the mathematical community came to recognize an aspiring mathematician as one of its own.
R9AP stabilizes RGS11-Gβ5 and accelerates the early light response of ON-bipolar cells
Authors: JEFFREY BRETT G. , MORGANS CATHERINE W. , PUTHUSSERY THERESA , WENSEL THEODORE G. , BURKE NEAL S. , BROWN R. LANE , DUVOISIN ROBERT M.
Published: January 2010

The rate-limiting step in the recovery of the photoreceptor light response is the hydrolysis of GTP by transducin, a reaction that is accelerated by the RGS9–Gβ5 complex, and its membrane anchor, R9AP. Similar complexes, including RGS7, RGS11, and Gβ5, are found in retinal ON-bipolar cell dendrites. Here, we present evidence that R9AP is also expressed in the dendritic tips of ON-bipolar cells. Immunofluorescent staining for R9AP revealed a punctate pattern of labeling in the outer plexiform layer, where it colocalized with mGluR6. In photoreceptors, R9AP is required for proteolytic stability of the entire regulator of G protein signaling complex, and we found that genetic deletion of R9AP also results in a marked reduction in the levels of RGS11 and Gβ5 in the bipolar cell dendrites; the level of RGS7 was unaffected, suggesting the presence of another interaction partner to stabilize RGS7. To determine the effect of R9AP deletion on the response kinetics of ON-bipolar cells, we compared the electroretinogram (ERG) between wild-type and R9AP-deficient mice. The ERG b-wave, reflecting ON-bipolar cell activity, was delayed and larger in the R9AP-deficient mice. Our data indicate that R9AP is required for stable expression of RGS11–Gβ5 in ON-bipolar cell dendrites. Furthermore, they suggest that the RGS11–Gβ5–R9AP complex accelerates the initial ON-bipolar cell response to light.
Parent conflict predicts infants' vagal regulation in social interaction
Authors: Moore Ginger A.
Published: January 2010

Parent conflict during infancy may affect rapidly developing physiological regulation. To examine the association between parent conflict and infants' vagal tone functioning, mothers (N = 48) reported levels of parent conflict and their 6-month-old male and female infants' respiratory sinus arrhythmia (RSA) was measured in the still-face paradigm. Higher parent conflict was related to lower RSA at baseline and each episode of the still-face paradigm. Infants in relatively higher conflict families showed attenuated RSA withdrawal in response to mothers' disengagement and attenuated RSA activation when interacting with mothers. Findings suggest atypical RSA regulation and reliance on self-regulation for infants in families with moderate levels of parent conflict. Implications for later development and future research are discussed.
Imitating actions on objects in early-onset and regressive autism: Effects and implications of task characteristics on performance
Authors: Rogers Sally J. , Young Gregory S. , Cook Ian , Giolzetti Angelo , Ozonoff Sally
Published: January 2010

This study was designed to examine the nature of object imitation performance in early autism. We hypothesized that imitation would be relatively preserved when behaviors on objects resulted in salient instrumental effects. We designed tasks in which, in one condition, the motor action resulted in a salient, meaningful effect on an object, whereas in the other condition, the same action resulted in a less salient effect because of differing object characteristics. The motor aspects of the tasks did not vary across conditions. Four participant groups of 2- to 5-year-olds were examined: 17 children with early-onset autism, 24 children with regressive onset autism, 22 children with developmental delays, and 22 children with typical development. Groups were matched on nonverbal skills, and differences in verbal development were examined as a moderator of imitative ability. Results revealed an interaction of group by condition, with the combined autism group failing more tasks than the combined comparison groups, and failing more tasks in the less salient condition than in the more salient condition, as hypothesized. Analyses of autism subgroups revealed these effects were primarily because of the regression onset group. Accuracy of motor performance was examined by analyzing errors. Among children passing imitative acts, there were no group differences and no condition effects in the number, type, or pattern of performance errors. Among children passing the tasks, the group with autism did not demonstrate more emulation errors (imitating the goal but not the means) than other groups. There was no evidence that either motor or attentional aspects of the tasks contributed to the poorer imitative performance of the children with autism.
Predictors and sequelae of trajectories of physical aggression in school-age boys and girls
Authors: Campbell Susan B. , Spieker Susan , Vandergrift Nathan , Belsky Jay , Burchinal Margaret ,   THE NICHD EARLY CHILD CARE RESEARCH NETWORK
Published: January 2010

Teacher-rated trajectories of physical aggression in boys and girls from first through sixth grade were examined using data from the NICHD Study of Early Child Care and Youth Development. In separate analyses, four trajectories were identified in boys and three in girls. Higher levels of aggression in both boys and girls were related to greater sociodemographic risk and higher maternal harshness in the preschool years; lower levels of observed maternal sensitivity during early childhood also predicted higher trajectories of aggression among girls. Trajectory groups also differed on a range of social and academic adjustment outcomes in sixth grade, with the most aggressive children and even moderately aggressive children evidencing some difficulties in adjustment. Patterns and levels of aggression in boys and girls are discussed as are their predictors and consequences.
Transitioning to adolescence: How changes in child personality and overreactive parenting predict adolescent adjustment problems
Authors: van den Akker Alithe L. , Deković Maja , Prinzie Peter
Published: January 2010

The present study examined how changes in child Big Five personality characteristics and overreactive parenting during the transition from childhood to adolescence predict adolescent adjustment problems. The sample included 290 children, aged 8–9 years. At three moments, with 2-year intervals, mothers, fathers, and a teacher reported on the child's personality, and mothers and fathers reported on their parenting behavior. At the third measurement moment, mothers, fathers, and children reported on the child's adjustment problems. Rank-order stability of the personality dimensions and overreactive parenting were high. Univariate latent growth models revealed mean-level decreases for extraversion, conscientiousness, and imagination. Mean levels of benevolence, emotional stability, and overreactive parenting were stable. Multivariate latent growth models revealed that decreases in extraversion and emotional stability predicted internalizing problems, whereas decreases in benevolence, conscientiousness, and emotional stability predicted externalizing problems. Increases in overreactive parenting predicted externalizing, but not internalizing problems. The associations were similar for boys and girls. The results indicate that changes in child personality and overreactive parenting during the transition to adolescence are associated with adolescent adjustment problems. Overall, child personality was more important than overreactive parenting, and children were more likely to “act out” than to “withdraw” in reaction to overreactive parenting.
Attenuation of cortisol across development for victims of sexual abuse
Authors: Trickett Penelope K. , Noll Jennie G. , Susman Elizabeth J. , Shenk Chad E. , Putnam Frank W.
Published: January 2010

Inconsistencies exist in literature examining hypothalamic–pituitary–adrenal (HPA) axis activity in children and adults who have experienced childhood abuse. Hence, the extent and manner to which childhood abuse may disrupt HPA axis development is largely unknown. To address these inconsistencies, the developmental course of nonstress cortisol in a long-term longitudinal study was assessed at six time points from childhood through adolescence and into young adulthood to determine whether childhood abuse results in disrupted cortisol activity. Nonstress, morning cortisol was measured in 84 females with confirmed familial sexual abuse and 89 nonabused, comparison females. Although dynamically controlling for co-occurring depression and anxiety, hierarchical linear modeling (HLM) showed that relative to comparison females, the linear trend for abused females was significantly less steep when cortisol was examined across development from age 6 to age 30,t(1, 180) = −2.55,p< .01, indicating attenuation in cortisol activity starting in adolescence with significantly lower levels of cortisol by early adulthood,F(1, 162) = 4.78,p< .01. As a more direct test of the attenuation hypothesis, supplemental HLM analyses of data arrayed by time since the disclosure of abuse indicated that cortisol activity was initially significantly higher,t(1, 425) = 2.18,p< .05, and slopes were significantly less steept(1, 205) = −2.66,p <.01, for abused females. These findings demonstrate how the experience of childhood abuse might disrupt the neurobiology of stress, providing some support for the attenuation hypothesis that victims of abuse may experience cortisol hyposecretion subsequent to a period of heightened secretion.
Parent–child attachment and internalizing symptoms in childhood and adolescence: A review of empirical findings and future directions
Authors: Brumariu Laura E. , Kerns Kathryn A.
Published: January 2010

The purpose of this paper is to evaluate the theory and evidence for the links of parent–child attachment with internalizing problems in childhood and adolescence. We address three key questions: (a) how consistent is the evidence that attachment security or insecurity is linked to internalizing symptoms, anxiety, and depression? (b) How consistent is the evidence that specific forms of insecurity are more strongly related to internalizing symptoms, anxiety, and depression than are other forms of insecurity? (c) Are associations with internalizing symptoms, anxiety, and depression consistent for mother–child and father–child attachment? The current findings are consistent with the hypothesis that insecure attachment is associated with the development of internalizing problems. The links between specific insecure attachment patterns and internalizing problems are difficult to evaluate. Father–child and mother–child attachments have a comparable impact, although there are relatively few studies of father–child attachment. No moderators consistently affect these relations. We also propose two models of how attachment insecurity may combine with other factors to lead to anxiety or depression.
‘Hello, we're outrageously punctual’: Front door rituals between friends in Australia and France
Authors: BÉAL CHRISTINE , TRAVERSO VÉRONIQUE
Published: January 2010

This paper presents a comparative analysis of Australian and French social visits between friends from an interactional perspective. The study focuses on the first few exchanges that take place as the guests come face to face with their host and are ushered in across the threshold and shows similarities, but also significant differences, in the three main elements that are regularly used in these ‘crossing the threshold’ exchanges: greetings, miscellaneous comments (on setting, arrival time, etc), and laughter.
Un même code éthique: deux univers de travail différents
Authors: TRÉGUER-FELTEN GENEVIÈVE
Published: January 2010

Cet article propose une analyse de discours contrastive des documents professionnels qu'une entreprise multinationale adresse à son personnel en deux versions linguistiques différentes (anglais-américain et français) de statut égal. Produits au terme d'un processus collectif complexe (écriture en anglaislingua francaet ‘bi-textes’) visant à en faire des documents identiques, ces Principes d'Action révèlent pourtant des dissemblances. On en cherche la cohérence en croisant les analyses énonciative, sémantique et linguistique des diverses catégories sur lesquelles reposent les différences, avant de conclure à une représentation d'univers de travail distincts dans lesquels, entre autres, l'autorité s'exerce différemment, notamment en fonction des sujets concernés. On s'interroge, pour finir, sur les liens entre les univers de travail représentés et la culture des sociétés concernées.
Pragmatique culturelle et traduction de la comédie de répertoire (du français à l'italien)
Authors: DUFIET JEAN-PAUL
Published: January 2010

La traduction de la comédie de répertoire distingue la tendance archaïsante, qui conserve la forme et la culture originelles du texte dans la version L2, et la tendance modernisante, qui, pour satisfaire la communication contemporaine, accommode les différents niveaux du texte au destinataire L2. Dans trois traductions italiennes contemporaines deLe malade imaginaire, on a constaté que l'orientation archaïsante domine. Cependant, l'opposition stricte des deux tendances est fréquemment dépassée, car la traduction de la comédie veut surtout conserver ses effets pragmatiques sur le spectateur. Il n'est donc pas rare que le texte traduit mélange les procédés indépendamment de son orientation générale.
Developing waist-to-height ratio cut-offs to define overweight and obesity in children and adolescents
Authors: Nambiar Smita , Hughes Ian , Davies Peter SW
Published: January 2010

Objective

The waist-to-height ratio (WHtR) assesses abdominal adiposity and has been proposed to be of greater value in predicting obesity-related cardiovascular health risks in children than BMI. The present study aims to develop WHtR cut-offs for overweight and obesity based on the 85th and 95th percentiles for the percentage body fat (%BF) in a cohort of children and adolescents.

Design

Waist circumference (WC), height, triceps and subscapular skinfolds were used to calculate WHtR and %BF. Correlations between WHtR and %BF and WHtR/mid-abdominal skinfold were made. Receiver-operating characteristic (ROC) curve analysis was used to select WHtR cut-offs to define overweight and obesity. Subjects were grouped by WHtR cut-offs, and mean values for anthropometry, blood lipids and blood pressure (BP) variables were compared.

Setting

Australian primary and secondary schools.

Subjects

A total of 2773 male (M) and female (F) subjects of the 1985 Australian Health and Fitness Survey, aged 8–16 years.

Results

Correlation coefficients between WHtR and %BF were M:r= 0·73, F:r= 0·60,P< 0·01 and WHtR/mid-abdominal skinfold were M:r= 0·78, F:r= 0·65,P< 0·01. WHtR of 0·46(M) and 0·45(F) best identified subjects with ≥85th percentile for %BF and 0·48(M) and 0·47(F) identified subjects with ≥95th percentile for %BF. When comparing the highest WHtR group to the lowest, both sexes had significantly higher means for weight, WC, %BF, TG (male subjects only), systolic BP (female subjects only) and lower means for HDL cholesterol (P< 0·05).

Conclusions

WHtR is useful in clinical and population health as it identifies children with higher %BF at greater risk of developing weight-related CVD at an earlier age.
Direct Insights on Flax Fiber Structure by Focused Ion Beam Microscopy
Authors: Domenges Bernadette , Charlet Karine
Published: January 2010

In this article, it is shown that focused ion beam (FIB) systems can be used to study the inner structure of flax fibers, the use of which as a reinforcing material in polymer composites still draws much interest from multiple disciplines. This technique requires none of the specific preparations necessary for scanning electron microscopy or transmission electron microscopy studies. Irradiation experiments performed on FIB prepared cross sections with very low Ga+ion beam currents revealed the softer material components of fibers. Thus, it confirmed the presence of pectin-rich layers at the interfaces between the fibers of a bundle, but also allowed the precise localization of such layers within the secondary cell wall. Furthermore, it suggested new insights on the transition modes between the sublayers of the secondary cell wall.
Simulation Study of Aberration-Corrected High-Resolution Transmission Electron Microscopy Imaging of Few-Layer-Graphene Stacking
Authors: Nelson Florence , Diebold Alain C. , Hull Robert
Published: January 2010

Graphene is a single layer of carbon atoms arranged in a hexagonal lattice. The high carrier mobility and mechanical robustness of single layer graphene make it an attractive material for “beyond CMOS” devices. The current work investigates through high-resolution transmission electron microscopy (HRTEM) image simulation the sensitivity of aberration-corrected HRTEM to the different graphene stacking configurations AAA/ABA/ABC as well as bilayers with rotational misorientations between the individual layers. High-angle annular dark field–scanning transmission electron microscopy simulation is also explored. Images calculated using the multislice approximation show discernable differences between the stacking sequences when simulated with realistic operating parameters in the presence of low random noise.