bluuebunny/crossref_metadata_2025 huggingface dataset:
Expanding drug therapy options for menopausal syndrome in patients with breast cancer
Authors:   Novorossiysk Clinical Center, Novorossiysk, Russian Federation, Pokul L.V. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Yasko B.A. ,   Kuban State Medical University, Kuban, Russian Federation,   Kuban State University, Kuban, Russian Federation, Lebedeva M.G. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Orazov M.R. ,   Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Sakultsan O.S. ,   Novorossiysk Clinical Oncology Dispensary No 3, Novorossiysk, Russian Federation
Published: April 2022

Objective. To study the effect of allogeneic placental therapy with Melsmon® on the quality of life of breast cancer (BC) patients with assessing possible risks of disease recurrence. Patients and methods. This study included 71 patients of reproductive age (38.3 ± 5.5 years) with invasive BC without signs of cancer grade 2–3 after complex treatment. All patients had a moderate-to-severe form of menopausal syndrome (MS). All women were divided into two groups: group I (study group, n = 33), in which human placenta hydrolysate (Melsmon®/Melsmon) was used to relieve menopausal symptoms; in group II (comparison group, n = 38), therapy with sedatives, vitamins, and phytotherapy were used. Allogeneic placental therapy with Melsmon® was used for 4 weeks (2 mL subcutaneously every other day (3 times a week)), then all patients received maintenance dosage: 2 mL subcutaneously twice a week for 8 weeks (total course of treatment was 12 weeks). Results. The study group (Melsmon®-therapy) showed a 3-fold decrease in vegetative disorders after 12 weeks, while this change was not observed in group II. There was a marked improvement in sleep quality in women in group I. The analysis of the stressors included in the approval list of the used psychodiagnostic method showed that stress reactions of respondents in group I in the form of anxiety, irritability, worries about uncontrollable life events, loss of confidence in the ability and possibility to solve personal problems were significantly lower than those in the women included in group II. During Melsmon®-therapy, positive dynamics of lipid profile in patients in group I was observed. Overall, a 1.8-fold decrease in triglyceride levels and 1.8-fold decrease in low-density lipoprotein levels were found in group I, with a 1.3-fold increase in high-density lipoproteins secretion. Conclusion. The results demonstrated the efficacy of MS treatment with human placenta hydrolysate, which contributed to a pronounced reduction in vegetative, metabolic, and psychological manifestations of MS. No recurrence of breast cancer was detected during the therapy period to date. The use of Melsmon®-therapy can expand the possibilities of drug therapy to improve the quality of life in menopausal breast cancer patients. Key words: breast cancer, menopausal syndrome, lipid profile, human placenta hydrolysate
Ultrasound diagnosis of interstitial ectopic pregnancy. Current approaches
Authors:   “Clinic Zdraviya” LLC, Moscow, Russian Federation, Shishkina T.Yu. , Aksenova V.B. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: April 2022

The analysis of ultrasound elastography and three-dimensional (3D) ultrasound imaging of suspected pregnancy in the interstitial part of the fallopian tube in three patients is presented. The following diagnoses were confirmed: interstitial pregnancy; first identified myomatous node with impaired trophism in the interstitial part of the fallopian tube in combination with menstrual disorders; incomplete miscarriage combined with a presence of myomatous node in the interstitial part of the fallopian tube simulating ectopic nidation. According to elastography, both the fertilized egg and myomatous nodes in the interstitial part of the fallopian tube appeared as stiff relative to the myometrium with clearly visualized contours. Three-dimensional ultrasound imaging with modalities including multiplanar reconstruction, tomography, omni-view, and “niche” contributed to verifying the diagnosis. Laparoscopy was performed in all patients. Interstitial pregnancy and incomplete miscarriage were histologically confirmed. Key words: compression elastography, ectopic pregnancy, pregnancy in the interstitial part of the fallopian tube, elastographic patterns, three-dimensional ultrasound imaging, ultrasound elastography
Prevalence of overweight and obesity among adolescents in Bulgaria
Authors:   Department of Internal Diseases and General Medicine, Trakia University, Stara Zagora, Bulgaria, Todorova Sevdalina Alekova
Published: April 2022

Overweight and obesity among adolescents is one of the most serious public health problems of the 21st century. They play a potential role in the development of a number of socially significant non-communicable conditions and diseases. Objective. The aim of the study was to determine the prevelance of overweight and obesity among Bulgarian teenagers of both sexes and age range from 13 to 18 years based on anthropometric parameters – height, weight, and body mass index. Methods. It was conducted a survey of anthropometric indicators on a representative sample of region Stara Zagora, Bulgaria in September-October 2016. The study population included 481 school students aged 13-18 years. The classification of overweight and obesity status was determined by body mass index (BMI) for age and sex according to the WHO Growth Reference for children aged 5–19 years. Results. The results of the transversal study showed increased levels of overweight and obesity among adolescents – 14.96% and 3.74%, respectively. The percentage of overweight in the individual age groups ranged from 10.52% to 19.54%. The leaders in the sample on this indicator were 18-year-old male students – 11.49%. The prevalence of obesity among different age groups varied from 1.13% to 6.25%. The highest values of obesity were found in 13- and 14-year-old school students – 6.00% and 6.25%, respectively. Conclusion. The research found increased prevalence of overweight and obesity among Bulgarian adolescents aged 13–18 years. It requires effective health programs, active civic self-awareness, and personal participation to limit this extremely harmful process that has already reached a pandemic spread. Key words: adolescents, obesity, overweight, general practice, BMI
Vaccination status and causes of non-adherence to vaccination schedule in young children
Authors:   Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Bairova S.V. , Sakhno L.V. ,   Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Koltuntceva I.V. ,   Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Gaiduk I.M. ,   Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation
Published: April 2022

Objective. To evaluate the vaccination coverage in children aged 10 months to 3 years, identify the causes of non-adherence to vaccination schedule, and suggest strategies to ensure timely vaccination of children residing in two districts of Saint Petersburg. Materials and methods. We analyzed vaccination coverage (according to the National calendar) in 90 children aged 10 months to 3 years using the data from medical registration forms: child development cards (f.112/y) and vaccination cards (f.063/y). Parents of these children were asked to fill in online questionnaires to analyze their reasons for non-adhering to vaccination schedule. Fifty-two parents agreed to answer. Data analysis was performed using the Microsoft Excel 2010/DataAnalysis software. Results. The vaccination coverage varied between 71% (rubella) to 99% (tuberculosis). Many parents delayed vaccination. Completed vaccination with other vaccines was detected in 57% (pneumococcal vaccine) and up to 80% (hepatitis B) of patients. Revaccination was also delayed in many children. For example, 30% to 41% of children were revaccinated against diphtheria, pertussis, tetanus, polio, and pneumococcus later than it was planned in the schedule. We identified the mean age of children with completed age-appropriate vaccination. The time of delay was usually 1–3 months for different vaccines. Conclusion. The most common causes of non-adhering to vaccination schedule were as follows: untimely visit to a polyclinic (n = 61; 67.8%), temporary medical contraindications (n = 25; 27.8%), and parents' refusal to vaccinate their children 4.4% (n = 4; 4.4%). None of the participants had absolute medical contraindications to vaccination. The analysis of parents' questionnaires demonstrated the following results: 2 out of 52 parents refused to vaccinate their children (3.9%); 37 parents (71.2%) answered that they did not visit polyclinic in time because the child had mild respiratory infection; 3 parents (5.7%) reported that they had come in time; and 10 parents (19.2%) said that they had delayed vaccination for family reasons. We suggested special sanitary, educational, and organizational measures to increase the vaccination coverage among young children. Key words: vaccination, children, vaccine-preventable diseases, vaccination status
The effect of photodynamic therapy on gram-positive and gram-negative bacteria of the oral mucosa in children with disabilities
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kashtanova M.S. , Morozova N.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kozlitina Yu.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Tatulyan A.R. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Soroсina E.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Makarov V.I. ,   A.M.Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russian Federation,   National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russian Federation
Published: April 2022

This literature review on the antibacterial photodynamic therapy (aPDT) use in dentistry, its latest achievements, prospects and effectiveness in children with disabilities. The treatment methods using in modern clinical practice often turn out to be insufficiently effective, and the steady development of periodontal pathologies is determined in all social groups of the population, and especially in such children. They cannot independently carry out the rational oral care, and the oral cavity hygienic condition deteriorates, which means that the problem of the prevention and treatment of dental diseases in such children is an urgent task of the modern dentistry. The bacterial microflora composition of the oral cavity plays the special role in the periodontal disease development, and the structure of bacterial cell walls affects the effectiveness of aPDT. The article provides the information about the microbiological composition prevailing in the oral cavity in periodontal diseases, reflects the structural features of gram-positive and gram-negative bacteria, which have a significant impact on the photosensitizer penetration and the further procedure effectiveness. Various photosensitizer groups and sources for their excitation are also investigated. Various methods of the application and the latest approaches in the treatment of periodontal diseases with PDT in children with disabilities are described. APDT with various photosensitizers is considered as the most promising alternative approach to the periodontal disease elimination. Key words: photodynamic therapy, photosensitizer, periodontal disease, periodontal pathogenic microflora, gingivitis, cerebral palsy
Changes in the body mass index of children, adolescents, and youth: trends observed in the end of the 20th century and beginning of the 21st century
Authors:   Institute of Developmental Physiology Russian Academy of Education, Moscow, Russian Federation, Lyakh V.I. , Levushkin S.P. ,   Institute of Developmental Physiology Russian Academy of Education, Moscow, Russian Federation,   Russian State University of Physical Education, Sport, Youth, and Tourism, Moscow, Russian Federation, Skoblina N.A. ,   Institute of Developmental Physiology Russian Academy of Education, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: April 2022

The investigation of changes in the parameters reflecting physical development of children, adolescents, and youth under the influence of genetic, environmental, social, and other factors has both scientific and practical value. Objective. To analyze changes in the body mass index (BMI) of children, adolescents, and youth in the late 20th century and early 21st century in different countries. We used the information form the Scopus database and Russian citation databases. We observed global secular trends demonstrating increasing BMI index and the number of overweight and obese children, adolescents, and youth. The last 40 years were characterized by particularly worrying trends with the proportion of overweight and obese children and adolescents reaching 25.0%. From pathophysiological point of view, this leads to a number of metabolic diseases. In countries with a well-developed industrial sector, the secular trends in height of children, adolescents, and youth weakened in the last decade of the 20th century and in the beginning of the 21st century. By contrast, their body weight continued to increase during this period. Conclusion. Overweight and obesity have become so widespread globally that many researchers are currently talking about an obesity epidemic. Key words: children, body mass index, physical development
Review of the expert council materials «Diarrhea differential diagnosis depending on its pathogenesis in pediatric practice, the role of probiotic medications in its treatment»
Authors:   Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Gorelov A.V. , Zakharova I.N. ,   Russian Medical Academy of Continuous Professional Education, Makarova S.G. ,   National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation, Shikh E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Novik G.A. ,   Saint Petersburg State Pediatric Medical University, Usenko D.V. ,   Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Berezhnaya I.V. ,   Russian Medical Academy of Continuous Professional Education
Published: April 2022

On November 10, 2021, an online meeting of the expert council was held on the conference platform of the First Medical Channel. The subject was “Diarrhea differential diagnosis depending on its pathogenesis in pediatric practice, the role of probiotic medications in its treatment”. Leading Russian experts in the field of clinical pharmacology, gastroenterology, pediatrics, infectious diseases, and allergology-immunology took part in this meeting. As a result of the meeting, the main principles of diagnosis, treatment, and prevention of diarrhea in children were formulated, and an algorithm for using probiotics to treat diarrhea in children was developed. Conclusion. It is preferable to prescribe medicinal probiotics (with registration status) than a dietary supplement containing probiotic bacteria. Medicinal products containing a combination of strains of Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12, vitamins B1 and B6, which are approved for use in pediatric practice, are recommended for administration in diarrhea and in suspected antibiotic-associated diarrhea in children, regardless of etiology and pathogenesis, both during the acute period and the next 4 weeks as well as during the entire recovery period (the period of repair and convalescence). Key words: antibiotics, children, diarrhea, treatment, prophylaxis, strain-specific probiotics, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12
Diagnosis and treatment of diffuse lymphangiomatosis in an 8-year-old child
Authors:   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Agafonov G.M. , Agafonova M.K. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Kondratyev G.V. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Kanina L.Ya. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Sakhno L.V. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Malekov D.A. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Grebenuk M.M. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Makhin Yu.Yu. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Krasnogorskaya O.L. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation, Gabrusskaya T.V. ,   Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russian Federation
Published: April 2022

Lymphangiomatosis – heterogenic disease with generalized or multifocal lymphatic vessels proliferation in bones and extraosseous tissues. We report a case of 2-year monitoring of 8-year-old boy with diffuse lymphangiomatosis. We have described clinical manifestation, surgery, differential diagnosis, Sirolimus treatment, and changes in MRI-images. Prolonged unsuccessful chylothorax, that mimics pneumonia with exudative pleuritis at the onset, treatment was a distinctive feature of this rare disease. The absence of guidelines and certified for children use drugs prompted our multidisciplinary team to make a decision to prescribe off-label Sirolimus as a pathogenetic therapy for this patient. Annual admissions for examination and modulating of drug`s dose allow to correct the treatment according to serum concentration of Sirolimus and MRI changings in the dynamics. Personalized target therapy has resulted in positive outcomes in the treatment of such difficult patient Key words: children, chylotorax, lymphangiomatosis, Sirolimus
Cost effectiveness of biologicals in the treatment of juvenile idiopathic arthritis
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Sevostyanov V.K. ,   The Research Institute for Health Organization and Medical Management, Moscow, Russian Federation, Babich N.V. ,   Rostov State Medical University, Rostov-on-Don, Russian Federation, Kakorina E.P. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   M.F.Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russian Federation, Zholobova E.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   Morozov Children's City Clinical Hospital, Moscow Healthcare Department, Moscow, Russian Federation
Published: April 2022

Objective. To evaluate cost effectiveness of biologicals in the treatment of juvenile idiopathic arthritis (JIA) to plan financial resources and purchases of high-cost medicines. Materials and methods. We performed clinical and economic analysis of biologicals used in patients with polyarticular JIA (pJIA) and systemic JIA (sJIA) using the methods of cost minimization and cost effectiveness. Results. The lowest annual treatment costs for pJIA were observed in children aged <5 years and 6–11 years receiving tocilizumab and etanercept. Among patients aged 12–17 years, the lowest treatment costs were registered in those receiving adalimumab and etanercept. Etanercept and tocilizumab were the least expensive drugs used in children with sJIA aged <5 years and 6–11 years, whereas in sJIA patients aged 12–17 years, therapy with adalimumab and etanercept was associated with the lowest costs. Similar results were obtained in the analysis of cost effectiveness. Conclusion. Our findings should be used for cost optimization of therapy with biologicals for JIA patients from different age groups. This will increase the availability of expensive therapy, reduce the risk of disability, and preserve their ability to work in the future. However, the main criteria for choosing a drug should certainly be the disease phenotype and its manifestations. Key words: juvenile arthritis, biologicals, cost-effectiveness analysis
Reference intervals for blood parameters in young athletes
Authors:   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Grishina Zh.V. , Klyuchnikov S.O. ,   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Yashin T.A. ,   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Makarova G.A. ,   Kuban State University of Physical Culture, Sports and Tourism, Krasnodar, Russian Federation, Lomazova E.V. ,   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Bushueva I.E. ,   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Feshchenko V.S. ,   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Zholinsky A.V. ,   Federal Research and Clinical Center of Sports Medicine and Rehabilitation of Federal Medical Biological Agency, Moscow, Russian Federation, Pushkina T.A. ,   Federal Medical Biological Agency, Moscow, Russian Federation
Published: April 2022

Comprehensive medical examination (CMO) of athletes allows timely detection of different diseases and formation of risk groups. To increase the accuracy of CMO in young athletes, it is necessary to calculate reference intervals (RIs) for blood parameters considering sex, age, and sports specialization. Objective. To calculate RIs for blood parameters of young athletes under 18 years of age using the results of CMO collected for many years. Materials and methods. We analyzed 4,568 results of blood tests of athletes aged 14 to 18 years (2,385 boys and 2,183 girls) obtained within CMO of members of Russian national sports teams in 2015–2019. This study was conducted in the Federal Research and Clinical Center for Sports Medicine and Rehabilitation. Twenty-two blood parameters were evaluated. Athletes not admitted to training, with an unsatisfactory state of health, or with a history of diseases affecting the metabolic profile of the body were excluded from the analysis. At the first stage, we calculated RIs for blood parameters in athletes with the consideration of sex and age (age groups: 14–15 years and 16–17 years). At the second stage, we compared calculated RIs for blood parameters with RIs used in CMO of athletes in healthcare institutions of Federal Biomedical Agency of Russia. Conclusion. The analysis of calculated RIs for blood parameters in athletes demonstrated their significant and multidirectional differences from the reference ranges used in the practice of sports medicine. Key words: biochemical markers, metabolism, reference intervals, professional sport, comprehensive medical examination, juniors
Features of linear growth of pupils with different levels of physical development
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Gritsinskaya V.L. , Novikova V.P. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Khavkin A.I. ,   Research Clinical Institute of Childhood of the Moscow Region, Moscow, Russian Federation
Published: April 2022

Objective. Determine the options for pubertal spurt in children with different levels of physical development in pre-pubertal age. Patients and methods. The analysis of the annual increase in body length and weight indicators in 645 schoolchildren (331 boys and 314 girls) aged 8 to 16 years was carried out. Depending on the compliance of the child's body length indicator with the WHO Growth Reference 2007 standards at the age of 8, schoolchildren are divided into groups: with average physical development; with physical development above average; with physical development below average. Results. The dynamics of the increase in body length and weight during the pubertal growth spurt has differences in children with different levels of physical development. Acceleration of linear growth in boys with average physical development is of a prolonged and low-amplitude type. The pubertal growth spurt in children with physical development above average is more pronounced in amplitude and limited in time; with physical development below average – has a more pronounced amplitude and lasts a shorter time than peers with average physical development. In girls with all types of physical development, the pubertal leap in linear growth is insignificantly expressed and prolonged in time, especially in schoolgirls with average and above average physical development. Conclusion. The data can be useful as a guide in predicting the course of pubertal spurt in children in the practice of clinical examination of the child population, in determining adequate physical activity in physical education lessons at school and in sports clubs. Key words: puberty growth spurt, children, physical development
Los Efectos de la comunicación en la salud mental de la ciudadanía.
Authors: Álvarez Laura Beatriz
Published: April 2022

En el presente artículo realiza una revisión de más de 50 artículos en donde se logró sintetizar los resultados de diversos estudios centrados en la comunicación y el bienestar de la salud mental aplicado de manera directa al ser humano. Llegándose a observar que las aplicaciones de las comunicaciones en la sociedad actual juegan un papel muy importante porque en todas las acciones que ejecuta de manera directa o indirecta el ser humano llega a comunicar transmitiendo un mensaje persuasivo para nuestros receptores. No obstante, el poder lograr el bienestar de la salud mental esta íntegramente relacionado con las comunicaciones, el cerebro que es un receptor continuo de información es quien genera estos estados emocionales dependiendo de que la comunicación sea oportuna y veraz. Mediante la presente investigación podremos demostrar que las comunicaciones son un ámbito muy importante para mejorar la salud mental de los ciudadanos, por ello, las entidades públicas y privadas comunican con el objetivo de poder no sólo informar sino generar bienestar en su público objetivo, mejorando de esta forma la calidad de vida de los ciudadanos.

De tal manera, cabe indicar que la investigación esta orientada a mejorar el desarrollo social e integral de los pobladores logrando alcanzar en ellos desarrollos emocionales mediante el uso adecuado de las comunicaciones.
Redes sociales y resiliencia en educación infantil:
Authors: Fusté Forné Maria
Published: April 2022

La crisis del coronavirus provocó el cierre de las escuelas y estas debieron adaptarse rápidamente. Centros educativos y docentes tuvieron que ser resilientes para poder transmitir resiliencia tanto a familias como a infantes. Una de las herramientas para ello fueron las redes sociales. De este modo, el estudio de las redes sociales puede ser de utilidad para analizar la comunicación entre escuela y familia durante el confinamiento. La presente investigación analiza el contenido (cuantitativa y cualitativamente) de una red social (Instagram) de una escuela infantil con filosofía Reggio Emilia durante el período de confinamiento en España, para trazar su vinculación con la resiliencia. Los resultados muestran que en la mayoría de las publicaciones la escuela comparte con las familias contenidos para aumentar su resiliencia y bienestar, mostrando además un feedback positivo de estas. Entre los contenidos más destacados, se observa la importancia de los cuentos y la música, y un papel fundamental de las maestras. La resiliencia en tiempos de crisis es un factor muy importante para poder afrontar las adversidades con una actitud adaptativa. Por ello, la puesta en valor de cada acción en pro de la resiliencia es positiva para poder mejorar y ahondar en su importancia.
Adopting VR in the Classroom: Perceptions of bilingual and ESL education pre-service teachers
Authors: Figueroa Flores Jorge F , Huffman Lisa , Lozada Victor , Rosa Dávila Emarely
Published: April 2022

VIRTUAL REALITY IS AN IMMERSIVE TECHNOLOGY THAT IS GAINING MOMENTUM IN EDUCATION AND HAS LED TO NEW TEACHING APPROACHES. MOREOVER, IT HAS SPARK INTEREST IN EDUCATOR PREPARATION PROGRAMS AND ESPECIALLY IN THE TRAINING OF BILINGUAL AND ESL PRE-SERVICE TEACHERS. THIS ARTICLE SHOWCASES A QUALITATIVE STUDY CONDUCTED WITH N=27 UNDERGRADUATE BILINGUAL AND ESL PRE-SERVICE TEACHERS. THE STUDY SOUGHT TO DETERMINE THE PERCEPTION OF BILINGUAL AND ESL PRE-SERVICE TEACHERS WITH VR AND PROVIDE AN UNDERSTANDING OF VR MOBILE APPLICATIONS' EXPERIENCES. ALL RESULTS WERE OBTAINED FROM GUIDED REFLECTIONS MADE BY PRE-SERVICE TEACHERS ENROLLED IN THE COURSE THEORIES OF SECOND LANGUAGE ACQUISITION FOR ESL AND BILINGUAL TEACHER AT A UNIVERSITY LOCATED IN NORTH TEXAS. A CONTENT ANALYSIS WAS PERFORMED TO ANALYZE THE REFLECTIONS, AND THREE CATEGORIES WERE DETERMINED: STRENGTHS OF VR, LIMITATIONS OF VR, AND VR MOBILE APPLICATIONS. THE FINDINGS REVEALED A POSITIVE PERCEPTION TOWARDS THE STRENGTHS OF VR WITH 60%, INCLUDING PROMOTES STUDENT ENGAGEMENT (41%) AND MOTIVATES STUDENTS (29%). ON THE OTHER HAND, PRE-SERVICE TEACHERS PERCEIVED LIMITATIONS OF VR, INCLUDING ASSOCIATED COSTS (44%) AND THE ABILITY TO ACCESS THE INTERNET (31%). FINALLY, VR MOBILE APPLICATIONS WHICH OFFERED VR TOURS WERE PERCEIVED TO ENHANCE LEARNING EXPERIENCES, INCLUDING GOOGLE EXPEDITIONS (51%) AND VR TUBE (23%).
FSAID: Fog-based secure mutual authentication scheme for intelligent driving
Authors: salami yashar , khajehvand vahid
Published: April 2022

Intelligent driving has reduced traffic and accidents, which has increased road safety. One of the advantages of Smart vehicles is communication with the environment, communication with the environment makes the driver aware of the traffic situation and accidents, and other things. However, the vehicle needs to be able to authenticate the other party before exchanging data. In this paper, we propose a secure mutual authentication scheme for intelligent driving. We compare the proposed scheme with the security analysis Automated Validation of Internet Security Protocols and Applications (AVISPA) tool and then compare the proposed scheme with other existing schemes in terms of communication, computation cost, and the number of bits. We simulated the proposed design with tools NS3, and it has been examined in terms of Packet Delivery, Throughput, and End-to-End Delay in different scenarios. The results show that the proposed scheme is resistant to known attacks and has a low communication cost and medium computation cost compared to other schemes.
Analysis of lacrimal duct morphology from cone-beam computed tomography dacryocystography in a Japanese population
Authors: Nakamura Jutaro , Kamao Tomoyuki , Mitani Arisa , Mizuki Nobuhisa , Shiraishi Atsushi
Published: April 2022

Purpose: The dacryoendoscope is a practical instrument for the examination and the treatment of lacrimal duct obstruction. Nevertheless, being a rigid fiberscope, manipulation of the endoscope is somewhat affected by the patient's lacrimal duct alignment and the skeletal structure of the face. The morphology and inclination of the lacrimal duct vary among individuals and ethnic groups. We aimed to evaluate the alignment of the lacrimal duct from the perspective of endoscopic maneuverability in a Japanese population.Methods: This is the retrospective study analyzed the cone-beam computed tomography dacryocystography (CBCT-DCG) images of 102 patients diagnosed with unilateral primary acquired nasolacrimal duct obstruction (PANDO) at Ehime University Hospital from December 2015 to May 2021. The following parameters of the lacrimal duct on the contralateral side of unilateral PANDO were investigated: (1) angle formed by the superior orbital rim–internal common punctum–nasolacrimal duct opening, (2) angle formed by the lacrimal sac and the nasolacrimal duct, (3) length of the lacrimal sac, and (4) length of the nasolacrimal duct.Results: Measurements of the above parameters were (1) 10.2° ± 7.8° (range, −11° to +27°), (2) −6.3° ± 14.1° (range, −43° to +40°), (3) 8.9 ± 2.3 mm (range, 4.3–17.1), and (4) 13.2 ± 2.7 mm (range, 5.7–20.7), respectively. The values of all parameters except (3) followed a normal distribution. No significant difference was found between the female and male groups.Conclusions: This study reported anthropometric analysis data of the morphology of the lacrimal ducts using CBCT-DCG in a Japanese population. In our cohort, the line from the superior orbital rim through the internal common punctum to the nasolacrimal duct opening inclined anteriorly in 92% of the patients, which indicated that compared with using straight probes, utilizing a bent tip or a curved probe was considered more appropriate in reducing superior orbital rim interference.
Interesting Case of Multiple Sebaceous Horn on the Penis
Authors: Ahamad Mohammad Nafees , Sultana Guljabin
Published: April 2022

Sebaceous horn commonly occurs on sun-exposed areas. A 50-year-old male presenting with multiple sebaceous horn involving the glance and prepuce of the penis is reported here. The horns were excised with a rim of normal tissue in the base. Histopathological examination reported no malignancy.
Development of a highly efficient virus-free regeneration system of Salvia miltiorrhiza from Sichuan using apical meristem as explants
Authors: Yao Si cheng , Jiang Yuan Yuan , Ni Su , Wang Long , Feng Jun , Yang Rui Wu , Yang Li Xia , Len Qiu Yan , Zhang Li
Published: April 2022

Bcakground:
The dry root and rhizome of Salvia miltiorrhiza are used to treat cardiovascular diseases, chronic pain, and thoracic obstruction over 2000 years in Asian countries. For high quality, Sichuan Zhongjiang is regarded as the genuine producing area of S. miltiorrhiza. Given its abnormal pollen development, S. miltiorrhiza from Sichuan (S.m.-SC) relies on root reproduction and zymad accumulation; part of diseased plants present typical viral disease symptoms and seed quality degeneration. This study aim to detected unknown viruses from mosaic-diseased plants and establish a highly efficient virus-free regeneration system to recover germplasm properties.
Results
Tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) were detected from mosaic-diseased plants. Primary apical meristem with two phyllo podium in 0.15–0.5 mm peeled from diseased plants were achieved 73.33% virus-free rate. The results showed that the medium containing MS, 0.5 mg/L 6-BA, 0.1 mg/L NAA, 0.1 mg/L GA3, 30 g/L sucrose and 7.5 g/L agar can achieve embryonic-tissue (apical meristem, petiole and leaf callus) high efficient organogenesis. For callus induction, the optimal condition was detected on the medium containing MS, 2 mg/L TDZ, 0.1 mg/L NAA by using secondary petiole of virus-free plants under 24 h dark/d condition for 21 d. The optimal system for root induction was the nutrient solution with 1/2 MS supplemented with 1 mg/L NAA. After transplant, the detection of agronomic metric and salvianolic acid B content confirmed the great germplasm properties of S.m.-SC virus-free plants.
Conclusions
A highly efficient virus-free regeneration system of S.m.-SC was established based on the detected viruses to recover superior seed quality. The proposed system laid support to control disease spread, recover good germplasm properties in S.m.-SC.
Late non-fasting plasma glucose predicts cardiovascular mortality independent of hemoglobin A1c
Authors: Wang Yutang , Fang Yan
Published: April 2022

It is unknown whether non-fasting plasma glucose (PG) is associated with cardiovascular disease (CVD) mortality. This study aimed to investigate this association in US adults. This study included adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. Mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PG for CVD mortality. Among 34,907 participants, 1,956, 5,564, and 27,387 had PG from participants in early non-fasting, late non-fasting, and fasting states, respectively (defined as a period since last calorie intake of 0-2.9, 3.0-7.9, or ≥ 8.0 h, respectively). This cohort was followed up for 455,177 person-years (mean follow-up, 13.0 years), with 2,387 CVD deaths being recorded. After adjustment for all confounders including hemoglobin A1c (HbA1c), only late non-fasting PG (continuous, natural log-transformed) was positively associated with CVD mortality risks (hazard ratio, 1.73; 95% confidence interval, 1.12–2.67). Higher late non-fasting PG (dichotomous, at a cut-off of 105, 110, or 115 mg/dL) was associated with higher CVD mortality risks. In addition, at the cut-off of 115 mg/dL, higher late non-fasting PG was associated with higher CVD mortality risks in those with either a normal (< 5.7%) or prediabetic HbA1c level (from 5.7–6.4%). In conclusion, late non-fasting PG predicts CVD mortality independent of HbA1c. Late non-fasting PG with a cut-off of 115 mg/dL may be used to identify those at high CVD risk.
Rapid protocols to support Covid-19 clinical diagnosis based on hematological parameters
Authors: Gomes Juliana Carneiro , Barbosa Valter Augusto de Freitas , de Santana Maíra Araújo , de Lima Clarisse Lins , Calado Raquel Bezerra , Junior Claudio Roberto Bertoldo , Albuquerque Jeniffer Emidio de Almeida , de Souza Rodrigo Gomes , de Araújo Ricardo Juarez Escorel , Moreno Giselle Machado Magalhães , Soares Luiz Alberto Lira , Júnior Luiz Alberto Reis Mattos , de Souza Ricardo Emmanuel , Santos Wellington Pinheiro dos
Published: April 2022

Purpose In December 2019, the Covid-19 pandemic began in the world. To reduce mortality, in addiction to mass vaccination, it is necessary to massify and accelerate clinical diagnosis, as well as creating new ways of monitoring patients that can help in the construction of specific treatments for the disease. Objective In this work, we propose rapid protocols for clinical diagnosis of Covid-19 through the automatic analysis of hematological parameters using Evolutionary Computing and Machine Learning. These hematological parameters are obtained from blood tests common in clinical practice. Method We investigated the best classifier architectures. Then, we applied the particle swarm optimization algorithm (PSO) to select the most relevant attributes: serum glucose, troponin, partial thromboplastin time, ferritin, D-dimer, lactic dehydrogenase, and indirect bilirubin. Finally, we used decision trees to build four rapid protocols for Covid-19 clinical diagnosis. Results We developed a web system for Covid-19 diagnosis support. Using a 100-tree Random Forest, we obtained results for accuracy, sensitivity and specificity superior to 99%. After feature selection, results were similar. The four empirical clinical protocols returned accuracies, sensitivities and specificities superior to 98%. Conclusion By using a reduced set of hematological parameters common in clinical practice, it was possible to achieve results of accuracy, sensitivity and specificity comparable to those obtained with RT-PCR. It was also possible to automatically generate clinical decision protocols, allowing relatively accurate clinical diagnosis even without the aid of the web decision support system.
Selection and validation of suitable reference genes for gene expression studies in Callerya speciosa (Champ. ex Benth.) Schot under different experimental conditions
Authors: Yu Linchan , Ming Ruhong , Huang Ding , Qin Chunmei , Li Liangbo , Tan Yong , Huang Rongshao , Yao Shaochang
Published: April 2022

The accuracy of reverse transcription quantitative real-time PCR (RT-qPCR) is strongly depended on the stability of reference gene. Callerya speciosa, as a traditionally Chinese medicine, has a long cultivation history in south China. It is essential to select the suitable reference gene to obtain reliable RT-qPCR results when gene expression changes were evaluated. However, suitable reference genes in C. speciosa have not yet been investigated for accurate gene expression quantification under different experimental conditions. In this study, eight candidate reference genes (GAPDH, 60S, ACTIN, TUA2, TUB1, TIF5, UBQ, EF2) were selected from the transcriptome databases, and their expression stability under six experimental conditions (developmental stages, tissues, MeJA treatment, GA3 treatment, CPPU and PP333 treatment) was evaluated using ΔCT, geNorm, NormFinder, BestKeeper, RefFinder programs. The results showed that GAPDH was the optimal reference gene for all different experimental conditions, whereas ACTIN showed the most stability under the hormone treatments in C. speciosa. GAPDH and EF2 were proved to be the most stable genes for developmental stages, while different genes (GAPDH and TUB1) were stable reference genes for tissues. For treatments, ACTIN was identified as the most stable gene under most of hormone treatments. TUBI and ACTIN were at the beginning of the ranking order in PP333 treatment, while GAPDH and ACTIN were adequate for normalization in MeJA and GA3 treatments. TUBI and GAPDH were the most stable genes for CPPU treatment, while ACTIN was proved to be the most stable gene for three different treatments (MeJA, GA3 and PP333). Validation of reference genes was carried out by the target gene CsMYB36, which further confirmed their reliability. These results provided a theoretical basis for subsequent research on the regulation of functional gene expression in C. speciosa.
Ecological barriers mediate spatiotemporal shifts of bird communities
Authors: Marjakangas Emma-Liina , Bosco Laura , Versluijs Martijn , Xu Yanjie , Santangeli Andrea , Holopainen Sari , Mäkeläinen Sanna , Herrando Sergi , Keller Verena , Voříšek Petr , Brotons Lluís , Johnston Alison , Princé Karine , Willis Stephen , Aghababyan Karen , Ajder Vitalie , Balmer Dawn , Bino Taulant , Boyla Kerem Ali , Chodkiewicz Tomasz , Moral Juan Carlos del , Mazal Vlatka Dumbović , Ferrarini Alessandro , Godinho Carlos , Gustin Marco ,   Mikhail Kalyakin7, Knaus Peter , Kuzmenko Tatiana , Lindström Åke , Maxhuni Qenan , Molina Blas , Nagy Károly , Radišić Dimitrije  , Rajkov Saša , Rajković Draženko Z. , Raudonikis Liutauras , Sjeničić Jovica , Stoychev Stoycho , Szep Tibor , Teufelbauer Norbert , Ursul Silvia , Turnhout Chris van , Velevski Metodija , Vikstrøm Thomas , Wilk Tomasz , Voltzit Olga , Øien Ingar Jostein , Lehikoinen Aleksi
Published: April 2022

Species’ range shifts and local extinctions caused by global change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, elevation, and temperature gradients, can influence a community's ability to shift. Yet, ecological barriers are rarely considered in global change studies, potentially hindering predictions of biodiversity shifts. We used data from two consecutive European breeding bird atlases to calculate the geographic distance and direction between communities in the 1980's and their nearest compositional equivalent in the 2010’s and modelled their response to barriers. The ecological barriers affected both the distance and direction of bird community composition shifts, with coasts and elevation having the strongest influence. Combining ecological barriers and community shift projections can identify ecological corridors that facilitate shifts of species and communities under global change.
Differential effects of two NSAIDS on crayfish behavior and physiology: the need for multiple assays to quantify toxicological effects
Authors: Moore Paul A. , Neal Alexandra E.
Published: April 2022

The evaluation of pharmaceutical compounds using both sublethal and environmentally relevant concentrations is an understudied area within ecotoxicology. Additionally, studies assessing toxicity of these compounds often use a single measure to determine impact. There exists potential for a wide variety of complex and unpredictable effects in non-target organisms due to both the design of pharmaceutical compounds and the conservation of target receptors across different phyla. This study assessed the behavioral and physiological impacts of two common non-steroidal anti-inflammatory (NSAID) medications on crayfish using environmentally relevant concentrations (0.30, 1.5, 3, 30 µg/L). Male and female crayfish were exposed by submerging them in an aqueous solution of either ibuprofen or naproxen for a 24-hr period. Following exposure to either ibuprofen or naproxen sodium, there were no significant changes to crayfish consumptive behavior, however, physiology was significantly different. Oxygen consumption by exposed female crayfish was greater and occurred faster than non-exposed control female crayfish. Impacts of sublethal exposure from pharmaceuticals may lead to reduced fitness and alter community interactions or functions. The results of this study lead us to propose that further ecotoxicological studies utilize multiple measurements to investigate the effects of chemical exposure.
Counting the Social, Psychological and Economic Costs of COVID-19 for Cancer Patients
Authors: Kirby Ann , Drummond Frances , Lawlor Amy , Murphy Aileen
Published: April 2022

PurposeCancer patients were particularly vulnerable to the adverse impacts of the COVID-19 pandemic given their reliance on the health care system, and their weakened immune systems. This systematic review examines the social, psychological and economic impacts of COVID-19 on cancer patients.MethodsThe systematic search, conducted in March 2021, captures the experience of COVID-19 Wave I, when the most severe restrictions were in place globally, from a patient perspective.ResultsThe search yielded 56 studies reporting on the economic, social, and psychological impacts of COVID-19. The economic burden associated with cancer for patients, during the pandemic included direct and indirect costs with both objective (i.e. financial burden) and subjective elements (financial distress). The pandemic exasperated existing psychological strain and associated adverse outcomes. Including: worry and fear (of COVID-19 and cancer prognosis); distress, anxiety, and depression; social isolation and loneliness. National and institutional public health guidelines to reduce COVID-19 transmission resulted in suspended cancer screening programmes, delayed diagnoses, postponed or deferred treatments and altered treatment. These altered patients' decision making and health seeking behaviours.ConclusionCOVID-19 compounded the economic, social, and psychological impacts of cancer on patients owing to health system adjustments and reduction in economic activity. Identification of the impact of COVID-19 on cancer patients from a psychological, social, and economic perspective following the pandemic can inform the design of timely and appropriate interventions and supports, to deal with the backlog in cancer care and enhance recovery.