bluuebunny/crossref_metadata_2025 huggingface dataset:
Resolução de problemas: um diagnóstico do ensino de Matemática nas Séries Finais do Fundamental
Authors: Ribeiro Gilson Alves , Queiroga Marcos Penha , Nascimento Dandara Lorrayne do
Published: November 2022

Ao longo da história da humanidade o ensino da matemática foi cercado por inúmeros medos e misticismos. Os estudantes, por vezes, apresentam receio frente aos aprendizados desta matéria. Para que este panorama começasse a se modificar, pesquisas começaram a ser realizadas para o ensino da Matemática, entre elas, destaca-se a Metodologia de Resolução de Problemas. Esta ferramenta busca possibilitar que o aluno consiga mobilizar conhecimentos e posteriormente desenvolver habilidades de gerenciar e processar conhecimentos para que as informações sejam melhor absorvidas. O presente trabalho teve como objetivo compreender a definição da Resolução de Problemas no ensino da matemática nos anos finais do ensino fundamental. Foi realizada uma revisão de literatura, para compreender de que forma os conceitos correlatos ao presente artigo são percebidos. Concluiu-se com o estudo que a Metodologia de Resolução de Problemas apresenta-se como importante ferramenta no processo de aprendizagem no ensino de matemática.
Perfil vacinal para a COVID-19 no município de Jaraguá do Sul, Santa Catarina
Authors: Daga Danielle , Santana Paula de Oliveira , Castro Adalberto Alves de , Nunes Lucas Rodrigo Hermes Leal da Costa , Grillo Luciane Peter
Published: November 2022

Objetivo: Traçar o perfil epidemiológico dos indivíduos vacinados no ano de 2021 no município de Jaraguá do Sul, SC. Métodos: Trata-se de um estudo transversal com abordagem quantitativa. A população foi composta pelos indivíduos vacinados contra o coronavírus, cadastrados no sistema de informação da Secretaria de Saúde do município de Jaraguá do Sul/SC, entre o período de 01/01/2021 a 31/12/2021. As variáveis avaliadas foram sexo, faixa etária, tipos e doses de vacinas, período de administração e bairros de residência. Resultados/Discussão: A prevalência maior de vacinação foi em indivíduos do sexo feminino (52,2%) e a faixa etária predominante foi de adultos. O bairro com maior cobertura vacinal foi o Ilha da Figueira, totalizando 17.328 pessoas vacinadas, seguido da Barra do Rio Cerro com 15.734 e Centro com 15.366. Foram vacinados 116.451 indivíduos com a primeira dose até dezembro de 2021, 109.568 com a segunda dose, 20.738 receberam dose de reforço e 6.168 receberam dose única. Até dezembro de 2021 obteve-se 80,3% de indivíduos vacinados com a primeira dose, caracterizando-se a imunidade de rebanho no município. Conclusões: A importância desta análise a nível municipal é fundamental na Atenção Básica, pois permite aplicar medidas de prevenção, promoção e educação em saúde.
Uso de medicamentos ansiolíticos e antidepressivos por estudantes universitários na área de saúde: uma revisão de literatura
Authors: Araújo Marielly Izabel de Alemida , Barboza Ana Clara de Sales , Guedes João Paulo de Melo
Published: November 2022

A ansiedade e a depressão são transtornos mentais cada vez mais comuns. O transtorno de ansiedade, na maioria das vezes é associado a sintomas físicos e psicológicos, como modificações de comportamento e humor, e pensamentos desagradáveis. Os altos índices de universitários da área da saúde com sintomas depressivos também estão correlacionados a uma maior suscetibilidade psicológica. O estudo foi realizado através de revisão bibliográfica do tipo integrativa. Sendo utilizando a base de dados Scientific Eletronic Library Online (SCIELO), Google Acadêmico e Biblioteca Virtual em Saúde (BVS-BIREME). Os cursos da área da saúde apresentam maior prevalência a desenvolver ansiedade e depressão. É decerto que a maioria dos universitários recorre ao uso de medicamentos psicotrópicos, principalmente ansiolíticos e antidepressivos, para aplacar os sintomas sofridos pela ansiedade e depressão. O objetivo geral desta pesquisa, revisar a literatura disponível em bancos de dados gratuitos, sobre os fatores, a prevalência e preferência de uso de quais medicamentos, e os riscos envolvidos perante seu uso inadequado.
Tratamento restaurador atraumático em dentes permanentes: uma revisão integrativa da literatura
Authors: Novais Isabela Miranda , Pinchemel Edite Novais Borges , Mania Taiomara Vieira
Published: November 2022

Introdução: A Odontologia de Mínima Intervenção (MI) é uma filosofia de tratamento que considera o manuseio de lesões cariosas com técnicas conservadoras. Entre elas o Tratamento Restaurador Atraumático (ART). Esta pesquisa buscou revisar a literatura acerca da longevidade do ART com cimento de ionômero de vidro de alta viscosidade. Metodologia: Trata-se de um estudo de revisão integrativa da literatura em que os dados foram coletados a partir de estudos primários, por meio de análise sistemática qualitativa, seguindo os parâmetros do PRISMA. A partir da pergunta norteadora: “Qual é a longevidade das restaurações atraumáticas em dentes permanentes?” por meio dos critérios PICO, utilizando a base de dados PubMed. Resultados: Coleta de artigos, extração de dados. Foram selecionados 12 artigos entre os anos de 2005 e 2020 que se enquadraram ao tema. Países como Brasil e China foram os mais participativos. Foram encontrados resultados favoráveis quanto a utilização da técnica ART, em que o CIVAV apresentou resultados comparáveis à RC e superiores aos CIVs convencionais num período de acompanhamento de 1-5 anos. As marcas mais utilizadas nos estudos foram Maxion, Fuji II, Vitremer e Filtek.  Uma das principais causas de falha foram perda do material/desgaste. Conclusão: foi possível concluir que apesar da heterogeneidade (quanto à melhor técnica e melhor material a ser utilizado), a ART possui bons resultados comparados a técnica convencional, não apresentando grandes diferenças significativas, e o CIVAV se equipara em sobrevida e sucesso à RC. Entretanto, a substituição pelos CIVs convencionais não assegura os mesmos resultados.
Impacto dos psicobióticos no transtorno da ansiedade
Authors: Pereira Dayana Cristina Santos , Moura Joara Neusa Sousa , Landim Liejy Agnes dos Santos Raposo
Published: November 2022

Objetivo: O objetivo desse estudo foi realizar uma busca de evidências científicas para analisar o impacto dos psicobióticos no tratamento da sintomatologia do transtorno da ansiedade. Metodologia: Trata-se de uma revisão da literatura narrativa realizada por meio de busca bibliografica de artigos português e inglês, disponiveis nas bases de dados Scielo e PubMed/MEDLINE. Foram incluidos artigos disponíveis na íntegra e do período entre 2013 a 2022. Os descritores utilizados foram: “Probioticos”, “Ansiedade”, “Probiotics” e “Anxiety”. Resultados: O cérebro e o intestino formam um eixo de comunicação de mão dupla, e as informações podem ser geradas tanto no nível do intestino quanto do cérebro, popularmente conhecido como eixo microbiota-intestino-cérebro, que pode estar direta ou indiretamente relacionado a certos distúrbios psicológicos, como ansiedade. Indicadores apontam que terapias capazes de modular a microbiota podem aliviar os sintomas de ansiedade, sendo uma dieta inadequada e pobre em nutrientes um fator de risco para esta patologia. Dessa forma, estudos têm demonstrado que a suplementação com probióticos (psicobióticos), principalmente as espécies Lactobacillus e Bifidobacterium, aliada a uma alimentação balanceada, tem apresentado resultados positivos. Considerações finais: Conclui-se que os psicobióticos das classes Lactobacillus e Bifidobacterium impactam positivamente no tratamento da sintomatologia da ansiedade. Desse modo, a suplementação de psicobióticos são apresentados como um complemento para o tratamento da ansiedade e fica evidente a importância de uma alimentação balanceada em conjunto com a suplementação probiótica para a saúde física e psicológica.
Implementação de oficina de geração de renda na atenção primária com mulheres: relato de experiência
Authors: Borges Anna Vitória Ferreira , Rezende Dalilla Matilde Ferreira de , Ferrari Andressa de França Alves
Published: November 2022

Objetivo: Relatar e refletir sobre a experiência da terapia ocupacional no processo de implementação de uma oficina de geração de renda com mulheres na atenção primária. Metodologia: Trata-se de um estudo qualitativo e descritivo do tipo relato de experiência, que foi desenvolvido através das vivências da profissional terapeuta ocupacional residente pelo Programa de Residência Multiprofissional em Saúde mental do Adulto da Escola Superior de Ciências da Saúde. Foram considerados para o relato 14 encontros acompanhados pela residente. Resultados: Através dos encontros foram selecionados 3 temas nos quais é feita ampla discussão, são eles: “A economia solidária através de oficinas de geração de renda”, “A prática da terapia ocupacional em oficinas de geração de renda” e “Grupo de mulheres e geração de renda.” Conclusão: Reflete-se que a implementação junto com o desenvolvimento das ações executadas na oficina de geração de renda, tornaram-se importantes possibilidades de ensino e aprendizagem para a residente terapeuta ocupacional em especialização em saúde mental. É compreendido que a proposta da Atenção Básica envolve mudança do modelo biomédico focado na doença e busca a consolidação de um cuidado integral e da clínica ampliada que enxerga o indivíduo em uma lógica biopsicossocial, se tornando a principal característica dos grupos de geração de renda com mulheres.
O papel da imunonutrição no combate à Covid-19: uma revisão integrativa
Authors: Vasconcelos Dayvid Murilo de Souza , Silva Ana Júlia da , Landim Liejy Agnes dos Santos Raposo
Published: November 2022

O objetivo desta presente revisão foi realizar uma busca acerca de evidências do papel da imunonutrição no enfrentamento de pacientes com covid-19. Trata-se de uma de revisão integrativa da literatura, as fontes de busca foram às bases de dados: Scientific Eletronic Library Online (Scielo), National Library of Medicine (PubMed), e Google Acadêmico. Para a seleção da amostra foi estabelecido critérios de artigos originais indexados entres os anos de 2019 a 2022, a escolha deste período atendeu ao critério de temporalidade, em que foi considerado o recorte de três anos, por se tratar de uma doença viral recente, na língua inglesa e portuguesa. Nos estudos foram analisados a possível função dos nutrientes, glutamina, arginina, Ômega-3 e vitamina C e D na modulação do sistema imunológico. É válido ressaltar que estes nutrientes tem ligação direta com a resposta imune que nosso organismo libera contra infecções, portanto, a imunonutrição é um importante instrumento a ser utilizado contra a infecção viral do covid-19. Com base nos resultados dos artigos examinados, foi observado que estes nutrientes obtiveram efeito positivo na recuperação, redução das sintomatologias e da mortalidade de pacientes com a doença, isto devido ao fato dos imunonutrientes exercerem função na diminuição da inflamação causada por uma resposta exarcebada do corpo para combater o vírus, concomitante a isto, estes imunonutrientes fortaleceram o sistema imunológico modulando de forma equilibrada as respostas imunes liberadas pelo corpo. Dessa forma, a modulação do sistema imunológico através da nutrição tem ação proveitosa para a recuperação de pacientes com Covid-19.
FAKTOR YANG HUBUNGAN DENGAN PELAKSANAAN IMUNISASI MR (MEASLES RUBELLA) DI DESA BACANG KECAMATAN BLANGKEJEREN KABUPATEN GAYO LUES
Authors: Ramadhani Syafitri Nasution Nurul Mouliza,
Published: November 2022

Latar Belakang: Menurut WHO Penyakit Measles dan Rubella (MR) merupakan penyakit yang kembali muncul dan menjadi perhatian dunia, World Health Organization (WHO) pada tahun 2016 mencatat angka kejadian kasus campak 30.000 kasus pertahun yang dilaporkan. Tujuan: Penelitian ini adalah untuk mengetahui apakah faktor pengetahuan, sikap, dukungan keluarga, presepsi kehalalan berhubungan dengan pelaksanaan imunisasi MR. Metode: Desain penelitian adalah survei analitik dengan rancangan penelitian cross sectional.  Populasi penelitian ini adalah  ibu yang mempunyai anak usia 9 bulan sampai 5 tahun. sampel penelitian yaitu sebanyak 40 orang ibu yang memiliki anak usia 9 bulan sampai 5 tahun. Penelitian ini dilakukan di Desa Bacang Kecamatan Blangkejeren Kabupaten Gayo Lues. Hasil: Penelitian yang dilakukan menggunakan uji chi-square di peroleh hasil p-value 0,002<0,05, yang artinya ada hubungan antara pengetahuan ibu dengan pelaksanaan imunisasi MR, p-value 0,006<0,05, yang artinya ada hubungan antara sikap ibu dengan pelaksanaan imunisasi MR. p-value 0,000<0,05, yang artinya ada hubungan antara dukungan keluarga dengan pelaksanaan imunisasi MR. p-value 0,009<0,05, yang artinya ada hubungan antara persepsi kehalalan dengan pelaksanaan imunisasi MR. Kesimpulan dan Saran: Penelitian ini adalah terdapat hubungan antara pengetahuan,sikap,dukungan keluarga dan persepsi kehalalan dengan pelaksanaan imunisasi MRdi Desa Bacang Kecamatan Blangkejeren Kabupaten Gayo Lues.
EFEKTIVITAS MEDIA AUDIOVISUAL DAN LEAFLET TERHADAP PENGETAHUAN PUS TENTANG METODE KONTRASEPSI IUD DI KAMPUNG KB PUMPUNG KECAMATAN CEMPAKA
Authors: Megawati Rabbiyati, Dewi Nur Azizah, Yuniarti,
Published: November 2022

Program Keluarga Berencana (KB) sebagai salah satu dari 4 pilar program intervensi penurunan kematian ibu (maternal) pada save motherhood. Program yang dilakukan oleh pemerintah untuk mengurangi laju pertumbuhan penduduk dapat dilakukan dengan gerakan Keluarga Berencana dan pemakaian alat kontrasepsi secara sukarela kepada PUS. Pumpung sebagai salah satu Kampung KB yang ada di Kota Banjarbaru. Presentase peserta KB aktif di Kota Banjarbaru menurut metode kontrasepsi MKJP sebanyak (16,16) sedangkan metode kontrasepsi Non MKJP sebanyak (86,88). Tujuan penelitian ini adalah untuk mengetahui Efektivitas Media Audiovisual Terhadap Pengetahuan dan Minat PUS tentang Metode Kontrasepsi Jangka Panjang di Kampung KB Banjarbaru

Rancangan penelitian yang digunakan pada penelitian ini adalah penelitian Quasy Experimental. pretest-posttest control group design menggunakan  media audiovisual  sedangkan  control diberikan leaflet. Sampel minimal untuk intervensi yaitu 40 subjek. 20  subjek diberikan  intervensi dengan audiovisual dan 20  subjek diberi leaflet. Teknik pengambilan sampel menggunakan Purposive Sampling.  Instrument yang digunakan kuesioner. Menggunakan data primer. Teknik analisis yang digunakan adalah t-Test.

Pengetahuan PUS tentang alat kontrasepsi IUD sebelum dan sesudah diberikan pendidikan kesehatan dengan media audiovisual didapatkan selisih rerata sebesar  0,550 dan  Pengetahuan PUS tentang alat kontrasepsi IUD sebelum dan sesudah diberikan pendidikan kesehatan dengan media leaflet didapatkan selisih rerata  1,500. Berdasarkan analisis  dapat diketahui bahwa nilai Asymp. Sig. (2-tailed) bernilai 0,077, artinya tidak ada perbedaan pengetahuan tentang kontrasepsi IUD antara sebelum dan sesudah diberikan pendidikan kesehatan dengan media audiovisual. hasil uji t-test bernilai 0,000. artinya ada perbedaan pengetahuan tentang kontrasepsi IUD antara sebelum dan sesudah diberikan pendidikan kesehatan dengan media leaflet. Dapat disimpulkan media leaflet  lebih efektif dari media audiovisual . Dalam memberikan pendidikan kesehatan dapat dilakukan dengan menggunakan media audiovisual maupun leaflet.

 

Kata kunci: Pengetahuan,  audiovisual, leaflet, KB
Molecular and microscopic identification of Eomarteilia granula infection in Manila clam Ruditapes philippinarum off the south coast of Korea
Authors: Kang HS , Lee HM , Itoh N , Cho YG , Choi KS
Published: November 2022

A report on the new species Eomarteilia (=Marteilia) granula infecting Manila clam Ruditapes philippinarum from Japan in 2014 suggests the possibility of E. granula infecting other Manila clam populations in the Northwest Pacific region, including Korea. In this study, we report the first infections by E. granula in Manila clams off the south coast of Korea. Histology revealed Marteilia-like plasmodia in the digestive tubule epithelia. Tissue imprints demonstrated that each parasite sporangium enclosed 4 spores and transmission electron microscopy (TEM) revealed ultrastructure of primary cells enclosing secondary cells, which contained spores. Mature spores consisted of 3 sporoplasms: outermost, intermediate, and innermost. The outermost sporoplasm showed a peripheral electron-dense monolayer characteristic of E. granula. The 18S rDNA amplified from the Marteilia-like parasite yielded 1784-bp PCR amplicon sequences which were 99.8% similar to that of E. granula previously reported (as M. granula) from Japan. In the molecular phylogenetic analysis, the novel Marteilia-like organism formed a well-supported clade with E. granula. Accordingly, we concluded that the novel Marteilia-like parasite that we found infecting some Korean Manila clams is Eomarteilia granula. Field surveys revealed that the infection was limited to clams of the south coast of Korea, with the prevalence ranging from 3.3 to 5.0%.
A mechanical approach for the punching shear provisions in the second generation of Eurocode 2
Authors: Muttoni Aurelio , Simoes Joao T. , Faria Duarte M.V. , Fernández Ruiz Miguel
Published: November 2022

The revision of a code is a long-term project that shall fulfil several aims, comprising the enhancement of the ease-of-use and incorporating updated state-of-the-art. With respect to the revision of Eurocode 2 concerning the punching shear provisions, this task allowed also for the opportunity to enhance the understanding of the code and physical phenomenon by designers. The original EN1992-1-1:2004 punching provisions were adapted from an empirical equation for design based on the regression analyses performed by Zsutty in the 1960s for shear in beams and later reworked in Model Code 1990 for punching shear. These expressions did not show any link to the physical response of a structure, making difficult to designers to clearly understand how to engineer their designs. Instead of continuing with this approach, CEN/TC250/WG1 took the decision in 2016 to ground the punching provisions on a mechanical model that could be explained to engineers, allowing for a transparent understanding of the design equations and phenomena. To that aim, the Critical Shear Crack Theory, already implemented in Model code 2010 at that time, was selected as representative of the state-of-the-art. Following that decision, a large effort has been performed to implement this theory into the Eurocode, keeping its simplicity of use and generality. This paper is aimed at presenting the theoretical ground of the theory as well as the manner in which it is drafted for the future generation of Eurocode 2.
Novel Immunotherapy Agents for Acute Lymphoblastic Leukaemia
Authors: Pesántez David , Rodriguez Adela , Oliver-Caldés Aina , Mozas Pablo , Esteve Jordi
Published: November 2022

Acute lymphoblastic leukaemia (ALL) in adults has a survival rate of 40–50% at 5 years, with a high relapse rate after first-line chemotherapy. After relapse, results with salvage therapy are currently unsatisfactory. Therefore, both the optimisation of front-line therapy to reduce relapse incidence and the search for effective salvage therapies for relapsed/refractory (r/r) ALL have been of great interest to the medical community in recent years. The well-characterised expression of well-defined cell-surface antigens in B cell ALL (B)-ALL and T cell (T)-ALL, such as CD19, CD20, CD22, and CD52, has led to the development of several immunotherapy strategies, comprising ‘nude’ monoclonal antibodies (moAbs), conjugated moAbs, bispeciphic, or highly sophisticated chimeric antigen receptor (CAR)-T cell therapy. Recently, both the bispecific moAb blinatumomab (anti-CD19 coupled with a CD3 recognition subunit) and the conjugated anti-CD22 moAb inotuzumab-ozogamicin have resulted in higher remission rates (44% versus 25%, and 80.7% versus 29.4%, respectively) and survival advantages (median overall survival [OS]: 7.7 months versus 4 months, and 7.7 months versus 6.7 months, respectively) in patients with r/r B-ALL when compared to standard salvage chemotherapy-based regimens. On the other hand, preliminary reports show feasibility and unprecedented response rates of ≤90% in highly refractory children and adults treated with CAR-modified T cells targeting the B cell specific CD19 antigen, which seem to be durable in a significant proportion of patients. Furthermore, the addition of anti-CD20 moAb rituximab to front-line standard chemotherapy in patients with CD20+ B-ALL has resulted in a clinical benefit, with prolongation of response duration and survival (3-year leukaemia-free survival and OS: 70% versus 38%; p<0.001, and 75% versus 47%; p=0.003). In conclusion, immunotherapy is currently providing additional options for high-risk ALL patients both in front-line or advanced phase. Nonetheless, the optimal positioning of these novel agents, specially in relation to allogeneic haematopoietic stem-cell transplantion, needs to be clarified. This article aims to review several of these new therapeutic immunotherapy options available for patients with adult ALL, as well as their specific toxicity profile.
Shifting Treatment Paradigms in Non-Hodgkin Lymphomas
Authors: Rossides Nicole
Published: November 2022

Despite significant therapeutic advances in the treatment of patients with non-Hodgkin lymphoma (NHL), a significant proportion experience relapse or progression following standard immunochemotherapy (ICT). The introduction of novel targeted immunotherapy agents has potentially ushered in a new era in the management of NHL. Emerging approaches to treatment, including chemo-free regimens, targeted therapies, and immunotherapy for follicular lymphoma (FL), mantle cell lymphoma (MCL), and diffuse large B-cell lymphomas (DLBCL), have become increasingly important. Furthermore, genomic tools and biomarkers support subtyping of lymphomas and contribute greatly to identifying patients likely to respond to therapy and predict treatment outcome, thus offering a subset-specific precision medicine approach to managing NHL to both prevent and treat relapse. The latest development in the management of NHL is the use of checkpoint inhibitors to prevent cell–cell communication and tumour growth. Despite limited evidence to date, checkpoint inhibitors in combination with existing ICT may fundamentally shift the NHL treatment algorithm towards personalised immunotherapy.
Analisi del discorso di classe sul riconoscimento di altezze di un triangolo
Authors: Lisarelli Giulia , Miragliotta Elisa
Published: November 2022

L’articolo presenta l’analisi del discorso matematico degli studenti di una classe II di scuola secondaria di primo grado, intrapreso durante una lezione sul riconoscimento di altezze di un triangolo. La lezione si è svolta dopo un percorso didattico durante il quale il discorso sull’oggetto matematico altezza si è costruito a partire da diverse realizzazioni possibili. Obiettivo principale di questo studio è documentare quali tra queste realizzazioni del significante altezza compaiono nel discorso di classe, descriverne le caratteristiche e osservare quali continuità o discontinuità presentano rispetto alle realizzazioni più comuni descritte dalla letteratura in didattica della matematica. L’analisi del discorso, accompagnata dalla costruzione e confronto tra l’albero di realizzazione atteso e l’albero della classe, consentiranno di mettere in luce sia la ricchezza del discorso di classe sia le interazioni tra realizzazioni diverse. Infine, si discuteranno le implicazioni teoriche e didattiche dello studio.
I cerchi nel grano
Authors: Lognoli David
Published: November 2022

La matematica alimenta lo spirito critico e democratico alla base di una cittadinanza consapevole. A tal fine la contestualizzazione è una risorsa per costruire un atteggiamento positivo degli allievi. L’intreccio della matematica con altre abilità è una necessità didattica per conseguire gli obiettivi del curriculum e uno strumento per mobilitare le diverse competenze per una valutazione personalizzata.Nella pratica d’aula questo approccio permette di superare la riproposizione di esercizi stereotipati e di mobilitare più competenze, consente inoltre di coinvolgere l’intera classe nel dialogo educativo e di valorizzare ogni contributo.L’idea sperimentata in aula, all’interno dell’unità didattica dedicata al cerchio e alla circonferenza, ha preso spunto da una famosa burla dei cerchi nel grano risalente agli anni ‘70. L’attività si è conclusa con una sfida creativa: il progetto di un cerchio nel grano. Oltre a richiedere la misura delle parti del cerchio ha sollecitato la progettazione di vere e proprie istruzioni operative per realizzare un cerchio nel grano.
COMPARISON OF ILLEGAL-UNREPORTED-UNREGULATED FISHING PRACTICES BASED ON PORT TYPE IN JAKARTA BAY
Authors: Ardisastra Ayi , Istiadi Yossa , Mansyur Umar
Published: November 2022

An assessment on Comparison of Illegal-Unreported-Unregulated (IUU) Fishing practices based on type of port in Jakarta Bay conducted on 8-12 February 2021 in 2 (two) classes of fishing port namely PPS (Pelabuhan Perikanan Samudra)   Nizam Zachman and PPN (Pelabuhan Perikanan Nusantara) Muara Angke. IUU Fishing violation practices is a fishing activity that is inconsistent and not in accordance with the conservation values and fisheries management, and violates international, regional, and national policies. Indonesia’s losses due to the practice of IUU fishing reach IDR 300 trillion annually or about 25% of Indonesia's total fishery potential. Aims of the assessment are to identify a violation rate of IUU Fishing, determine the value of IUU Fishing index and strategy for prevention and eradication of IUU Fishing practices in Jakarta Bay fishing port. Add the methods/analyse here … As a result of the studies showed that the highest of IUU Fishing violation rate occured at PPN Muara Angke which were about 184 of vessels compare with PPS Nizam Zachman which were only 63 vessels that contravene with rules. In addition, according to the index values of IUU Fishing at both fishing ports were moderate namely about 2,03 for PPS Nizam Zachman and 1,77 for PPN Muara Angke. Furthermore, based on the result of SWOT analysis that there are 3 (three) strategies to prevent and eradicate IUU Fishing practices consisted of: i) the strategy of optimization of integrated services which has a weight value of about 33,5%; ii) the strategy of establishment of law enforcement institution forum which has a weight value of about 31,3%; iii) the strategy of administration sanction for offender of unreported fishing which has a weight value of about 20,3%; and iv) the strategy of strengthening of vessels owner or patron (collectors) which has a weight value of about 15,0%
Prenatal exposure to alcohol: mechanisms of cerebral vascular damage and lifelong consequences
Authors: Saha Partha S. , Mayhan William G.
Published: November 2022

Alcohol is a well-known teratogen, and prenatal alcohol exposure (PAE) leads to a greater incidence of many cardiovascular-related pathologies. Alcohol negatively impacts vasculogenesis and angiogenesis in the developing fetal brain, resulting in fetal alcohol spectrum disorders (FASD). Ample preclinical evidence indicates that the normal reactivity of cerebral resistance arterioles, which regulate blood flow distribution in response to metabolic demand (neurovascular coupling), is impaired by PAE. This impairment of dilation of cerebral arteries may carry implications for the susceptibility of the brain to cerebral ischemic damage well into adulthood. The focus of this review is to consolidate findings from studies examining the influence of PAE on vascular development, give insights into relevant pathological mechanisms at the vascular level, evaluate the risks of ethanol-driven alterations of cerebrovascular reactivity, and revisit different preventive interventions that may have promise in reversing vascular changes in preclinical FASD models.
Mitochondrial dysfunction of induced pluripotent stem cells-based neurodegenerative disease modeling and therapeutic strategy
Authors: Luo Hong-Mei , Xu Jia , Huang Dan-Xia , Chen Yun-Qiang , Liu Yi-Zhou , Li Ya-Jie , Chen Hong
Published: November 2022

Neurodegenerative diseases (NDDs) are disorders in which neurons are lost owing to various factors, resulting in a series of dysfunctions. Their rising prevalence and irreversibility have brought physical pain to patients and economic pressure to both individuals and society. However, the pathogenesis of NDDs has not yet been fully elucidated, hampering the use of precise medication. Induced pluripotent stem cell (IPSC) modeling provides a new method for drug discovery, and exploring the early pathological mechanisms including mitochondrial dysfunction, which is not only an early but a prominent pathological feature of NDDs. In this review, we summarize the iPSC modeling approach of Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis, as well as outline typical mitochondrial dysfunction and recapitulate corresponding therapeutic strategies.
Hematophagy and tick-borne Rickettsial pathogen shape the microbial community structure and predicted functions within the tick vector, Amblyomma maculatum
Authors: Adegoke Abdulsalam , Kumar Deepak , Budachetri Khemraj , Karim Shahid
Published: November 2022

Background

Ticks are the primary vectors of emerging and resurging pathogens of public health significance worldwide. Analyzing tick bacterial composition, diversity, and functionality across developmental stages and tissues is crucial for designing new strategies to control ticks and prevent tick-borne diseases.

Materials and methods

Here, we explored the microbial communities across the developmental timeline and in different tissues of the Gulf-Coast ticks (Amblyomma maculatum). Using a high-throughput sequencing approach, the influence of blood meal and Rickettsia parkeri, a spotted fever group rickettsiae infection in driving changes in microbiome composition, diversity, and functionality was determined.

Results

This study shows that the core microbiome of Am. maculatum comprises ten core bacterial genera. The genus Rickettsia, Francisella, and Candidatus_Midichloria are the key players, with positive interactions within each developmental stage and adult tick organ tested. Blood meal and Rickettsia parkeri led to an increase in the bacterial abundance in the tissues. According to functional analysis, the increase in bacterial numbers is positively correlated to highly abundant energy metabolism orthologs with blood meal. Correlation analysis identified an increase in OTUs identified as Candidatus Midichloria and a subsequent decrease in Francisella OTUs in Rickettsia parkeri infected tick stages and tissues. Results demonstrate the abundance of Rickettsia and Francisella predominate in the core microbiome of Am. maculatum, whereas Candidatus_Midichloria and Cutibacterium prevalence increase with R. parkeri-infection. Network analysis and functional annotation suggest that R. parkeri interacts positively with Candidatus_Midichloria and negatively with Francisella.

Conclusion

We conclude that tick-transmitted pathogens, such as R. parkeri establishes infection by interacting with the core microbiome of the tick vector.
Antibiotic ampicillin induces immune tolerance in renal transplantation by regulating the proportion of intestinal flora in mice
Authors: Wu Xiaoqiang , Cao Guanghui , Wang Zhiwei , Wu Xuan , Tian Xiangyong , Gu Yue , Shao Fengmin , Yan Tianzhong
Published: November 2022

Objectives

There are significant differences in the composition of intestinal flora in renal transplant recipients before and after an operation, which has a great impact on the prognosis of renal transplantation. The purpose of this project is to study the effect of intestinal flora imbalance on renal transplantation.

Methods

The animal model of renal transplantation was established after intestinal flora imbalance (mice pretreated with compound antibiotics), or the animal model of renal transplantation was established after being pretreated with single antibiotics. HE, PAS, and Masson staining was used to detecting the histopathological changes of transplanted renal. The expression of inflammatory factors and infiltration of inflammatory cells of renal tissue were respectively been detected by ELISA kit and flow cytometry.

Results

Antibiotic pretreatment restored weight loss, and decreased serum creatinine level in mice after renal transplantation. The tissue staining, ELISA assay, and flow cytometry data showed that antibiotic pretreatment alleviated injury of the renal allograft, inhibited the inflammatory factors levels, and reduced inflammatory cell infiltration in mice after renal transplantation. Furthermore, single antibiotic, especially ampicillin pretreatment can also play the same role as compound antibiotics, such as restoring weight loss, decreasing serum creatinine level, alleviating renal allograft injury, inhibiting inflammatory factors levels, and reducing inflammatory cell infiltration in mice after renal transplantation.

Conclusions

Antibiotic ampicillin may inhibit inflammatory cell infiltration after renal transplantation by regulating the proportion of intestinal flora in mice, to reduce renal injury and play a role in renal protection.
Machine learning and synthetic outcome estimation for individualised antimicrobial cessation
Authors: Bolton William J. , Rawson Timothy M. , Hernandez Bernard , Wilson Richard , Antcliffe David , Georgiou Pantelis , Holmes Alison H.
Published: November 2022

The decision on when it is appropriate to stop antimicrobial treatment in an individual patient is complex and under-researched. Ceasing too early can drive treatment failure, while excessive treatment risks adverse events. Under- and over-treatment can promote the development of antimicrobial resistance (AMR). We extracted routinely collected electronic health record data from the MIMIC-IV database for 18,988 patients (22,845 unique stays) who received intravenous antibiotic treatment during an intensive care unit (ICU) admission. A model was developed that utilises a recurrent neural network autoencoder and a synthetic control-based approach to estimate patients’ ICU length of stay (LOS) and mortality outcomes for any given day, under the alternative scenarios of if they were to stop vs. continue antibiotic treatment. Control days where our model should reproduce labels demonstrated minimal difference for both stopping and continuing scenarios indicating estimations are reliable (LOS results of 0.24 and 0.42 days mean delta, 1.93 and 3.76 root mean squared error, respectively). Meanwhile, impact days where we assess the potential effect of the unobserved scenario showed that stopping antibiotic therapy earlier had a statistically significant shorter LOS (mean reduction 2.71 days, p-value <0.01). No impact on mortality was observed. In summary, we have developed a model to reliably estimate patient outcomes under the contrasting scenarios of stopping or continuing antibiotic treatment. Retrospective results are in line with previous clinical studies that demonstrate shorter antibiotic treatment durations are often non-inferior. With additional development into a clinical decision support system, this could be used to support individualised antimicrobial cessation decision-making, reduce the excessive use of antibiotics, and address the problem of AMR.
Glacial history and depositional environments in little Storfjorden and Hambergbukta of Arctic Svalbard since the younger dryas
Authors: Joe Young Jin , Jang Kwangchul , Forwick Matthias , Laberg Jan Sverre , Kong Gee Soo , Kang Moo-Hee , Yoon Seok-Hoon , Nam Seung-Il
Published: November 2022

Geophysical and lithological data provide crucial information for the understanding of glacial history in Arctic Svalbard. In this study, we reconstructed the glacier-induced depositional environments of Little Storfjorden and its tributary, Hambergbukta, over the last 13 ka to better understand the glacial history of southeastern Svalbard. The combined uses of swath-bathymetry, high-resolution seismic stratigraphy, and multiple-proxy measurements of sediment cores allowed us to define five steps of glacier-induced depositional environments: 1) deposition of massive, semi-consolidated gravelly sandy mud (Facies 1) during re-advance or still-stand of the marine-based glaciers/ice streams in Little Storfjorden during Younger Dryas (13–12 ka); 2) deposition of massive mud to gravelly sandy mud (Facies 2A and B) during glacial retreat until the earliest Holocene (12–10.1 ka); 3) sediment winnowing by enhanced bottom currents during the early to middle Holocene (10.1–3.7 ka); 4) deposition of bioturbated sandy mud (Facies 3) with high productivity under seasonal sea ice conditions during the late Holocene (3.7–0.7 ka); and 5) deposition of (slightly) bioturbated sandy to gravelly mud (Facies 4) affected by glacier surges since Little Ice Age (LIA) (Facies 4). In addition to seismic stratigraphy, depositional patterns of IRD in Little Storfjorden indicate that the glacier surges in Hambergbukta occurred only after ∼0.7 ka. This suggests that the terminal moraine complex (TMC) represents the maximum extent of the LIA surges, which argues against the recent inference for the TMC formation during pre-LIA. This study shows the importance of multiple parameters to better understand the current behavior of tidewater glaciers in the Svalbard fjords in response to rapid climate change.
Gastroesophageal reflux related changes after sleeve gastrectomy and sleeve gastrectomy with fundoplication: A retrospective single center study
Authors: Aili Aikebaier , Maimaitiming Maimaitiaili , Maimaitiyusufu Pierdiwasi , Tusuntuoheti Yusujiang , Li Xin , Cui Jianyu , Abudureyimu Kelimu
Published: November 2022

Background

The worsening of gastroesophageal reflux disease (GERD) and “de novo” GERD after laparoscopic sleeve gastrectomy (LSG) is a major concern as it affects the patient’s quality of life; the incidence of GERD after LSG is up to 35%. Laparoscopic sleeve gastrectomy with fundoplication (LSGFD) is a new procedure which is considered to be better for patients with morbid obesity and GERD, but there is a lack of objective evidence to support this statement. This study aimed to assess the effectiveness, safety, and results of LSG and LSGFD on patients who were morbidly obese with or without GERD over an average of 34 months follow-up.

Methods

Fifty-six patients who were classified as obese underwent surgery from January 2018 to January 2020. Patients who were obese and did not have GERD underwent LSG and patients who were obese and did have GERD underwent LSFGD. The minimum follow-up time was 22 months and there were 11 cases lost during the follow-up period. We analyzed the short-term complications and medium-term results in terms of weight loss, incidence of de novo GERD/resolution of GERD, and remission of co-morbidities with follow-up.

Results

A total of 45 patients completed the follow-up and a questionnaire-based evaluation (GERD-Q), of whom 23 patients underwent LSG and 22 patients underwent LSGFD. We had 1 case of leak after LSGFD.No medium or long- term complications. The patient’s weight decreased from an average of 111.6 ± 11.8 Kg to 79.8 ± 12.2 Kg (P = 0.000) after LSG and from 104.3 ± 17.0 Kg to 73.7 ± 13.1 Kg (P = 0.000) after LSGFD. The GERD-Q scores increased from 6.70 ± 0.5 to 7.26 ± 1.7 (P = 0.016) after LSG and decreased from 8.86 ± 1.3 to 6.45 ± 0.8 (P = 0.0004) after LSGFD. The incidence of de novo GERD after LSG was 12 (52.2%) at the 12 month follow-up and 7 (30.4%) at the mean 34 (22–48) month follow-up. The remission of reflux symptoms, for patients who underwent LSGFD, was seen in 19 (86.4%) of 22 patients at 12 months and 20 (90.9%) of 22 patients at the mean 34 (22-48) month follow-up. The two groups did not have any significant difference in the effect of weight reduction and comorbidity resolution.

Conclusion

The incidence of de novo GERD after LSG is high,LSG resulted in the same weight loss and comorbidity resolution as LSGFD, in patients who are morbidly obese and experience GERD, and LFDSG prevent the occurrence and development of GERD, combination of LSG with fundoplication (LSGFD) is a feasible and safe procedure with good postoperative results,which worthy of further clinical application.
Dysglycemia in young women attenuates the protective effect against fatty liver disease
Authors: Pérez-Montes de Oca Alejandra , Julián María Teresa , Pera Guillem , Caballería Llorenç , Morillas Rosa , Torán Pere , Expósito Carmen , Franch-Nadal Josep , Mauricio Didac , Alonso Nuria
Published: November 2022

Introduction

Sexual dimorphism has been reported in non-alcoholic fatty liver disease (NAFLD), similar to the sex differences evident with cardiovascular disease. Type 2 diabetes mellitus (T2D) significantly increases the risk and severity of NAFLD, but there is scarce information on whether T2D or altered glucose metabolism can modify the prevalence of NAFLD in men and women of reproductive age.

Purpose

To investigate the relationship between age, sex and NAFLD in subjects with and without dysglycemia.

Materials and methods

We analyzed 2,790 patients. NAFLD was characterized using established diagnostic criteria: one or more positive results on the fatty liver index and hepatic ultrasound. Liver fibrosis (liver stiffness measurement [LSM] ≥8.0 kPa) was assessed by Fibroscan®. For analysis purposes, we included both T2D and prediabetes under the predefined condition of dysglycemia.

Results

The global prevalence of NAFLD was higher in men than in women (50% and 34%; P<0.001), and the prevalence increased with age in both sexes. Older women (≥ 50 years) had a higher prevalence than younger women (<50 years), both in the overall cohort and in non-dysglycemic subjects. In dysglycemic subjects, the prevalence of NAFLD was slightly higher in men (68% vs 61%, p=0.021); in younger subjects, there were no differences in the prevalence of NAFLD between men and women (68% vs 64%, respectively; p=0.635). We found an interaction between dysglycemia and female sex (odds ratio [OR] 1.6 95% confidence interval [CI] 1.0-2.4, p=0.030), and between and age ≥50 years (OR 0.6, 95% CI 0.3-1.0, p=0.046). The global prevalence of LSM ≥8.0 kPa was higher in men compared with women (8% vs 4%; p< 0.001). This prevalence increased with age, mainly in men. We did not find any association between liver fibrosis and age and gender.

Conclusions

While the global prevalence of NAFLD is higher in men than in women across all ages, younger women with dysglycemia have a similar risk of developing NAFLD as men of a similar age. Therefore, the presence of dysglycemia may erase the protective effect of female sex against fatty liver disease.
Biochemical and molecular responses of the freshwater snail Pila sp. to environmental pollutants, abiotic, and biotic stressors
Authors: Panda Falguni , Pati Samar Gourav , Das Kajari , Samanta Luna , Sahoo Dipak Kumar , Paital Biswaranjan
Published: November 2022

The semi-sessile, ectothermic, amphibious mollusc Pila globosa receives less attention for studying its environmental aspects. Its ecological role, ecotoxic and physiological responses to environmental factors including pollution and during dormant periods such as hibernation and estivation to understand key information about many cellular metabolic events need to be revealed. We reviewed the ecotoxic and physiological responses of P. globosa to various abiotic and biotic stressors such as heavy metals, organophosphorous, carbamate and butachlor in relation its adaptation to energy expenditure, fat metabolism in the dormant period, desiccation, etc. The responses analysed in terms of oxidative stress, respiratory and antioxidant enzymes, carbohydrate metabolism and activities of neurotransmitter enzymes such as acetylcholinesterase to better understand the connection between environmental factors and metabolic events in P. globosa. Articles published in the English language from 1952 to July of 2022 in PubMed, Google search engine and AGRICOLA that describes any of the above-mentioned search terms in P. globosa were included in the review article. Articles not containing any of the above terms were excluded. The 41 results were found in PubMed and 10 results from AGRICOLA and about 80 filtered articles from Google, totaling about 80 articles published until July 2022 were included in this review. The varied enzymatic activities observed in this organism under the exposure to various chemicals imply their possible use as biomarkers of eco-toxicological studies in freshwater and grassland ecosystems, for example, alleviated body carbohydrate and protein contents are up to 32% and 37% during aestivation and hibernation, respectively. Similarly, activities of enzymes such as adenosine monophosphate deaminase, adenosine deaminase, succinic dehydrogenase, cytochrome-c-oxidase, and glutamate dehydrogenase are downregulated by 75.5%, 62.6%, 54%, 59%, and 62%, respectively, during above inactive periods. Acetylcholinesterase enzyme is found to be the most susceptible enzyme to be downregulated by 225%, 130%, 64%, 198%, 96.08% in this snail under exposure to environmental pollutants such as phorate (30 mg/L), formothion (37.5 mg/L), trichlorfon (2.5 mg/L), aldicarb (120 mg/L) and butachlor (100 µ moles), respectively. In conclusion, P. globosa can serve as a reliable ectothermic model for comparative ecotoxicological studies in grassland and freshwater environmental monitoring.
Mapping the big data analytics in sharing economy: A bibliometric literature review
Authors: Yang Yuxue , Su Xiang , Yao Shuangliang , Tao Chen
Published: November 2022

This paper offers a holistic review of the role of big data analytics in sharing economy (SE). Academic literature in this field is analyzed to show the theoretical foundation, important papers, and key themes underlying the field by using various bibliometric analysis tools. We conduct a citation and co-citation analysis on literature concerning big data analytics in sharing economy, which published in the 12-year period from 2010–2021. A total of 205 papers were screened from Web of Science (WoS) database for our analysis. In the citation analysis, we depend on the degree centrality and betweenness centrality to identify 48 important papers. In the co-citation analysis, four major research themes are identified: sustainable business model, efficient match-making, trust building and innovation and value cocreation. The research also highlights future research directions and critical areas for the application of big data analytics in the SE context, which may help to produce in-depth studies.
Can industrial diversification help strengthen regional economic resilience?
Authors: He Dan , Miao Pengjia , Qureshi Naveed Akhtar
Published: November 2022

Strengthening economic resilience is the key to stable economic growth in various regions. Previous studies have paid more attention to the level and evolution trend of economic resilience, and seldom Dissected the reasons for differences in regional economic resilience. This paper takes 243 cities in China as the research object and explains the reasons for the differences in regional economic resilience from the perspective of industrial diversification. The results show that industrial diversification helps to improve the level of regional economic resilience. Compared with related diversification, unrelevant diversification has a more significant effect on economic resilience. The region’s own endowment conditions will also affect the effect of industrial diversification on economic resilience. Diversified industries can better promote regional economic resilience in more economically developed cities. The development of industrial diversification also depends on the support of external factors such as finance, technological innovation, and human capital. Therefore, increasing the investment in these factors will also help to positively adjust the role of industrial diversification in promoting economic resilience. Our research helps to understand the reasons for the formation of regional economic resilience, and the research results provide a scientific basis for optimizing sustainable development policies.