bluuebunny/crossref_metadata_2025 huggingface dataset:
Rotenone, Rhodamine 123 and Janus Green Induce Damage to Nuclear DNA in Ascites Tumor Cells from Mice, Rotenone and Rhodamine in X-Irradiated Cells Contribute to the Maintenance of Genome Integrity
Authors: Kuznetsova E. A , Sirota N. P
Published: September 2024

Rotenone, Rhodamine 123, and Janus green B, inhibitors of mitochondria function, are currently investigated to create pharmacological agents that induce mitochondrial dysfunction and apoptosis. Since impaired mitochondrial function is associated with overproduction of reactive oxygen species, it seems relevant to compare DNA damage induced by the said inhibitors in Ehrlich ascites carcinoma cells and murine lymphocytic leukemia P388 and DNA damage induced by the direct effect of ionizing radiation (X-rays) that induces an increase of reactive oxygen species. The alkaline comet assay was used for measuring the level of DNA damage. The level of Rotenone-induced DNA damage was comparable to that one induced by very low-dose radiation (4 Gy) for both cell types. Post-irradiation incubation of cells led to a reduction in the level of DNA damage, indicating that damage to DNA is repaired. Treatment of Ehrlich ascites carcinoma cells with Rhodamine 123 and subsequent washing them for removal of excess dye did not cause an increase in the level of DNA damage, however, exposure to very low dose radiation (4 Gy) in the presence of Rhodamine 123 induced an increase in the level of DNA damage, which was significantly reduced after 1-hour incubation. It can be assumed that pre-treatment of cells with Rotenone or Rhodamine 123 that disrupt mitochondrial function contributed to the maintenance of the integrity of nuclear DNA in irradiated cells. Exposure to Janus green B caused an increase in the level of DNA damage and cell death. The alkaline comet assay revealed that damage induced by these compounds can be considered single- and double-strand breaks and alkali-labile (apurinic/apyrimidinic) sites in DNA.
Increased Drug Resistance in Acute Lymphoblastic Leukemia Cells in Three-Dimensional High-Density Cell Cultures
Authors: Shtatnova D. Yu , Kobyakova M. I , Lomovskaya Y. V , Fetisova E. I , Krasnov K. S , Fadeev R. S
Published: September 2024

In this study, the development process of drug resistance in acute lymphoblastic leukemia cells (Jurkat, MOLT 3, and MOLT 4 cell lines) was examined in high-density cell cultures. It has been shown that in highdensity cultures of acute lymphoblastic leukemia cells resistance to the action of chemotherapeutic drugs increases comparing to the cells cultured under low-density conditions. The results obtained after investigation of the mechanism underlying increased drug resistance in acute lymphoblastic leukemia cells in high-density cell cultures showed that an increase in drug resistance in high-density cultures of cells can be mediated by a change in their proliferative activity. These findings can be applied in developing a strategy to overcome drug resistance in acute lymphoblastic leukemia cells, which depends on the density of the cell culture.
Adrenergic Regulation of the Functioning of the Cardiovascular System under Hypothermic Conditions
Authors: Galimova M. H , Averin A. S
Published: September 2024

Regulation of the function of the cardiovascular system under and after hypothermia is one of important and relevant tasks in biomedical research. It is because of both – serious complications of hypothermia and the potential outcome benefits with hypothermia used for medicinal purposes. Adrenergic regulation is central for the normal function of the cardiovascular system. There are three types of adrenergic receptors known as α1, α2 and β, the expression levels of which are different in the myocardium and blood vessels. Activation of each of the adrenergic receptor subtypes can cause differently directed effects, which are significantly modified under the conditions of low temperature. The effectiveness of β-adrenergic stimulation decreases and β-adrenergic stimulation can even act like hypothermia, leading to impairment of myocardial function. The severity of the effects of α1 adrenergic agonists both on myocardial tissue and in blood vessels is also diminished, however, sensitivity to stimulation of α1a receptors in blood vessels may increase. The activation of α1 adrenergic receptors mediates protective effect in the heart. The activation of α2 adrenergic receptors has a fairly wide range of protective effects on the heart. However, there is now increasing evidence of direct inotropic and vascular effects mediated by this type of receptor. There is also some evidence that these effects become more pronounced under hypothermia. This review examines the current state of research on the effects of stimulation of certain types of adrenergic receptors under normal and hypothermic conditions, analyzes the mechanisms of physiological action and prospects for their further research.
Features of the Effects of Exposure to 90–170 MeV Proton Radiation on the Blood-Forming Organs in Mice under Total Irradiation with Proton Pencil Scanning Beam Depending on the Linear Energy Transfer of Particles
Authors: Rozanova O. M , Belyakova T. A , Smirnova E. N , Sorokina S. S , Dyukina A. R , Shemyakov A. E , Strelnikova N. S
Published: September 2024

The effects on induction of cytogenetic damage to mouse bone marrow, generation of reactive oxygen species by whole blood cells, and on the thymus and spleen from exposure of mice to total-body proton radiation before and at the Bragg peak with a dose deposition of 0.1–1.5 Gy were investigated depending on the linear rate of energy loss. It was found that the level of polychromatophilic erythrocytes with micronuclei at all doses of proton radiation at the Bragg peak with the linear energy transfer 2.5 keV/μm was close to that of polychromatophilic erythrocytes with micronuclei for the corresponding doses of X-ray radiation with the linear rate of energy loss 2.0 keV/μm, and the level of cytogenetic damage induced by exposure to proton radiation up to the Bragg peak with the linear energy transfer 0.7 keV/μm was significantly lower. The coefficient of the relative biological effectiveness of proton irradiation calculated from the linear energy transfer by estimating micronuclei frequency at and before the Bragg peak was 1.15 and 0.63, respectively. Organ-specific differences in the patterns of pathophysiological effects on the thymus, spleen of mice and the state of the antioxidant system of blood cells depending on the linear energy transfer of protons were revealed by varying radiation doses.
Penetration of Polyphenols through Acetic Acid-Damaged Skin
Authors: Shubina V. S , Shatalin Yu. V
Published: September 2024

Our previous research has shown that derivatives of taxifolin, pentaglutarate of taxifolin and a conjugate of taxifolin with glyoxalic acid improve the mechanical properties of the collagen-based materials. During the degradation process of these materials, the biologically active polyphenols are released into the surrounding medium. To evaluate the penetration of polyphenols through burn-injured skin, two approaches were used. In case of pentaglutarate of taxifolin and taxifolin (they were used for comparison), polyphenols were labeled by fluorescent probe. In case of a conjugate, the fluorescent analogue was obtained. It was shown that the application of polyphenols on the damaged area of skin leads to the formation of fluorescent layer on its surface. It was found that hair follicles accumulate fluorescent derivatives of taxifolin and pentaglutarate of taxifolin. In regard to taxifolin, the fluorescence was observed in the deeper skin layers than that recorded for pentaglutarate of taxifolin, suggesting that taxifolin penetrate the skin more effectively. The fluorescent analogue accumulation in skin appendages showed lower values than that of other compounds. Thus, the data obtained demonstrate that polyphenols accumulate in hair follicles, from which they can be gradually released into the surrounding tissue. On the whole, our findings suggest that biologically active polyphenols are able to exert prolonged effects when they are used for topical application. This may be important while treating burns, especially second-degree burns, in which many skin appendages remain intact.
Trough bird fauna of the North Caucasus and features of its formation, the Botlikh trough-like depression of Inner Dagestan taken as an example
Authors: Belik V. P. , Nasrulaev N. I.
Published: September 2024

An analysis of the avifauna of the arid Botlikh depression in the mountains of Dagestan, where 112 breeding bird species have been recorded, shows noticeable transformations in its composition noted during the 19th to 21st centuries. Within the arid depression, an increase in the number and expansion of nemoral, forest-steppe and sub-Mediterranean dendrophiles is observed, as well as the appearance of Siberian mountain-taiga species at nesting sites. At the same time, there is a decrease in the number and the disappearance of xerophilic sclerophylls, which are part of the desert-mountain faunal complex of the Nomadian type of fauna. This may be due to both climate change, which affects birds indirectly through vegetation and a reduction in the specific food supply, and the consequences of anthropogenic impacts on the natural environment (forest restoration, degradation of agriculture and livestock breeding), possibly also through competitive relationships between some animal species. Similar changes are noted not only in the avifauna of Dagestan, but also in the Western Caucasus, as well as in the steppe zone in southern Russia, this indicating large-scale zoogeographic processes occurring there. The identified transformations of regional faunas require further, intensified faunal monitoring, which will make it possible to clarify the speed of ongoing processes and provide zoogeographic forecasts for the near future.
POTRET BUDAYA TORAJA DALAM CERPEN “DI TUBUH TARRA, DALAM RAHIM POHON” KARYA FAISAL ODDANG
Authors: Abdullah Risen Dhawuh
Published: September 2024

Dalam penciptaan karya sastra, tradisi budaya memang menjadi daya tarik tersendiri. Penelitian ini bertujuan untuk mendeskripsikan nilai-nilai budaya yang terkandung dalam cerpen “Di Tubuh Tarra, dalam Rahim Pohon” karya Faisal Oddang. Metode penelitian yang digunakan adalah deskriptif-kualitatif. Teknik pengumpulan data menggunakan metode simak-catat. Pendekatan yang digunakan adalah nilai-nilai budaya berdasarkan tujuh unsur nilai budaya yang dikemukakan oleh Koentjaraningrat meliputi (1) bahasa, (2) sistem pengetahuan, (3) organisasi sosial, (4) sistem peralatan hidup dan teknologi, (5) sistem mata pencaharian hidup, (6) sistem religi, dan (7) kesenian. Temuan dalam penelitian ini, tujuh unsur nilai budaya terdapat dalam cerpen “Di Tubuh Tarra, dalam Rahim Pohon” karya Faisal Oddang. Ketujuh unsur nilai budaya masyarakat Toraja tersebar dalam berbagai hal, antara lain penguburan bayi di pohon tarra, larangan berzina, sistem kasta, kepercayaan terhadap hal mistik, gotong royong, kebersamaan, pengetahuan tentang hal mistik, istilah bahasa Toraja, mata pencaharian. masalah, hingga penggunaan alat-alat produktif.
Centralne Archiwum Wojskowe Wojskowego Biura Historycznego – historia, organizacja, zasób
Authors: Kaczmarska Patrycja
Published: September 2024

The article discusses issues related to the functioning of the Central Military Archives of the Military Historical Bureau. Its history, organizational changes and archival resources are presented. The principles of sharing archival materials and the process of their digitization are also mentioned.
Kilka słów o najnowszej, dwutomowej monografii cmentarzy wokół Lwowa, autorstwa Barbary Patlewicz i Ryszarda Tomczyka
Authors: Olechowski Piotr
Published: September 2024

A review article on the two-volumemonography of cemeteries around Lviv.
Intracranial Drain-Related Intracerebral Hemorrhage in Two Sporadic Cerebral Amyloid Angiopathy Patients
Authors: Renard Dimitri , Sangare Birama , Youssouf Ansma , Thouvenot Eric
Published: September 2024

Alzheimer’s disease and cerebral amyloid angiopathy (CAA) are often associated. Amyloid accumulation within leptomeningeal and small/median-sized cerebral blood vessels in CAA results in vessel fragility, leading to spontaneous leptomeningeal bleeding, lobar intracerebral hemorrhage (ICH) and cerebral microbleeds. CAA is also associated with non-traumatic subdural hematoma. The role of CAA-related vessel fragility in hemorrhagic complications after trauma, brain surgery, and intracranial drain insertion in CAA is unknown. We present two sporadic CAA patients with intracranial drain-related ICH, probably due to different underlying mechanisms, related to indirect and direct CAA-associated vessel fragility.
Biofluid Markers and Tissue Biopsies Analyses for the Prodromal and Earliest Phase of Parkinson’s Disease
Authors: Pilotto Andrea , Zanusso Gianluigi , Antelmi Elena , Okuzumi Ayami , Zatti Cinzia , Lupini Alessandro , Bongianni Matilde , Padovani Alessandro , Hattori Nobutaka
Published: September 2024

The recent development of new methods to detect misfolded α-synuclein (αSyn) aggregates in biofluids and tissue biopsies in the earliest Parkinson’s disease (PD) phases is dramatically challenging the biological definition of PD. The αSyn seed amplification methods in cerebrospinal fluid (CSF) showed high sensitivity and specificity for early diagnosis of PD and Lewy bodies disorders. Several studies in isolated REM sleep behavior disorders and other at-risk populations also demonstrated a high prevalence of CSF αSyn positivity and its potential value in predicting the phenoconversion to clinically manifested diseases. Growing evidence exists for αSyn aggregates in olfactory mucosa, skin, and other tissues in subjects with PD or at-risk subjects. DOPA decarboxylase and numerous other candidates have been additionally proposed for either diagnostic or prognostic purposes in earliest PD phases. The newly described αSyn detection in blood, through its quantification in neuronally-derived exosome vesicles, represents a technical challenge that could open a new scenario for the biological diagnosis of PD. Despite this growing evidence in the field, most of method of αSyn detection and markers still need to be validated in ongoing longitudinal studies through an accurate assessment of different prodromal disease subtypes and scenarios before being definitively implemented in clinical settings.
Capitalism and Passions of People
Authors: Bílková Veronika
Published: September 2024

Albert O. Hirschman: Lidské vášně a osobní zájmy. Politická obhajoba kapitalismu v čase před jeho triumfem. 1. vydání. Brno: Centrum pro studium demokracie a kultury, 2000, 142 stran, ISBN 80-85959-63-1.
German Multilateralism and Relations among the Visegrad group countries
Authors: Handl Vladimír
Published: September 2024

German policy has experienced dynamic development and significant elements of change since the country's unification, mainly in the area of security and integration policy. However, German policy has been still defined to a great extent by its internal "institutional pluralism" (Bulmer, Paterson, Jeffery). The "pragmatization" of German integration policy (Schmalz) does not mean rejection of principal orientation on multilateralism. German policy towards the Visegrad group countries (the Czech Republic, Hungary, Poland and Slovakia) has focused mainly on normalisation of mutual relations and their gradual multilateralisation.
German concept thus reaches beyond the traditional buffer-zone concept of Central Europe. At the same time, Germany has become the most important but not the exclusive partner of the ECE countries. It has not become a hegemon either, as it can not effectively pre-define policy outcomes in the region. It has been moving towards the role of a "soft hegemon" developing a strategy of "milieu shaping" (Wolfers). It has, therefore, co-shaped the region by the way of co-operation, compromises, export of institutions, norms and political preferences. This process has taken place not instead of NATO - and EU-enlargement but in advance of it. The aim has been primarily to facilitate the enlargement process.
The outcome will further "empower" Germany (Bulmer) but the process can not be viewed as the building of a national hegemony. Moreover, the relations between Germany and the Visegrad group states will loosen after successful NATO and EU-enlargement: in a number of areas, different political preferences will surface. Also, unlike the Visegrad states, Germany has global interests and their centre of gravity still rests in the West, not in East Central Europe. Multilateral institutions set limits to oscillation from "normality" in the quality of relations between Germany and its Eastern neighbours.
Multilateralism is crucial also as a tool of how to solve the traditional German dilemma: how to, on the one hand, encounter the apprehensions of German partners (towards the West as well as towards the East) regarding both German power as well as weakness. On the other hand, how to meet their expectations that Germany should play a more active role in international affairs. The multilateral policy has been in principle placed higher than the approach to the "historical" agenda in Germany's relations with her Eastern neighbours.
Globalization, Identity and European Integration
Authors: Karlas Jan
Published: September 2024

In this study, I treat globalization as one of the sources of the ongoing debate on the future of the European Union (EU). The existing analyses usually regard EU's Eastern enlargement and the so-called democratic deficit of the EU decision-making as the two most important sources of this debate. However, the content of the documents and speeches that constitute the future of Europe debate reveals that EU political elite does also perceive globalization as an important incentive to define the finality of the European integration process and to reform EU institutions.
My aim in this study is to provide a theoretically based explanation of why the debate is taking place, but I seek to provide only a limited explanation as I only deal with one of the sources of the debate: globalization. In the theoretical part, I discuss a constructivist approach to the relationship between globalization and European integration developed by Ben Rosamond, which I use as the theoretical framework of my analysis. This approach claims that globalization works as an important factor of the social construction of Europe and its external context. In this way, globalization leads to the emergence of a particular collective identity among EU political elite and reinforces the regional level as a valid space for policy-making. On the basis of this claim, I hypothesize that one of the sources of the ongoing effort to define the finality of European integration is a particular identity of EU political elite coming into existence in connection with globalization.
In the empirical part, I test the hypothesis by making a discourse analysis based on the main documents of the European Commission and European Council and the speeches of the top British, French, and German state representatives on the future of the EU. The analysis confirms the hypothesis since it demonstrates that globalization is, indeed, interpreted by EU political elite as the process that takes place outside of Europe, defines Europe, and requires further deepening of European integration. Another finding of this study is, however, that it is relevant not only to test whether globalization leads to the emergence of a particular European identity, but also to examine what the content of that identity is. In his study, Rosamond describes that identity as the identity of Europe as a valid economic space.
Nevertheless, the analysis of the globalization discourse within the future of Europe debate shows that there is yet another European identity based on globalization: the identity of Europe as a global actor. This case study focused on the future of Europe debate and it suggests, therefore, that not only does globalization enable the construction of Europe as a space for policy-making at the regional level, but it also leads to the construction of Europe as an actor at the global level of policy-making.
Claus Giering - Josef Janning - Wolfgang Merkel - Michael Stabenow: Demokratie und Interessenausgleich in der Europäischen Union
Authors: Kratochvíl Petr
Published: September 2024

Claus Giering - Josef Janning - Wolfgang Merkel - Michael Stabenow: Demokratie und Interessenausgleich in der Europäischen Union. 1. Aufl. Gütersloh: Verlag Bertelsmann Stiftung, 1999, 87 stran, ISBN 3-89204-844-4.
Christopher Flavin - Brigitte Young - Christoph Scherrer - Klaus Zwickel u. a.: Global Governance: Gewerkschaften und NGOs - Akteure für Gerechtigkeit und Solidarität
Authors: Hřích Jan
Published: September 2024

Christopher Flavin - Brigitte Young - Christoph Scherrer - Klaus Zwickel u. a.: Global Governance: Gewerkschaften und NGOs - Akteure für Gerechtigkeit und Solidarität. Herausgegeben von der Otto-Brenner-Stiftung. 1. Aufl. Hamburg: VSA-Verlag, 2002, 159 stran, ISBN 3-87975-846-8.
PENEGAKAN HUKUM TERHADAP PELAKU TINDAK PIDANA PELECEHAN SEKSUAL KEPADA ANAK DI KABUPATEN PULAU TALIABU
Authors: Masuku Efiyanti , Ogotan Arianti A. , Daeng Maroa Mustating , Rays Moh. Ikhwan , Fality Firmansyah
Published: September 2024

Penelitian ini bertujuan untuk mengetahui penegakan hukum terhadap pelaku tindak pidana pelecehan seksual kepada anak di Wilayah Kepolisian Resor Pulau Taliabu dan faktor yang mempengaruhi penegakan hukumnya. Penelitian ini menggunakan metode penelitian yuridis empiris. Penegakan hukum terhadap pelaku tindak pidana pelecehan seksual kepada anak di Wilayah Kepolisian Resor Pulau Taliabu dilaksanakan oleh Satuan Reserse dan Kriminal melalui Unit Unit Pelayanan Perempuan dan Anak (PPA). Adapun langkah-langkah umum yang dilakukan dalam penegakan hukum melalui proses penyidikan tindak pidana pelecehan seksual terhadap anak adalah adanya laporan atau pengaduan, identifikasi dan perlindungan terhadap korban, pemeriksaan awal, penangkapan, dan penyidikan. Dalam proses penyidikan dilakukan penahanan, penggeledahan dan penyitaan. Sedangkan faktor yang mempengaruhi penegakan hukum terhadap pelaku tindak pidana pelecehan seksual kepada anak terdiri atas faktor pendukung yaitu faktor hukum, faktor aparat penegak hukum dan faktor budaya masyarakat. Adapun faktor yang menghambat meliputi faktor ketidakhadiran saksi dan Faktor belum adanya Balai Pemasyarakatan (Bapas).
Gyanús eltűnések és halálesetek – titkos információgyűjtés és egyéb hatósági intézkedések
Authors: Sidló Mariann
Published: September 2024

Az emberi élet a legnagyobb érték, ezért a rendőrség legfontosabb feladatai közé tartozik az eltűnések és a gyanús elhalálozások vizsgálata.A tanulmány célja feltárni az erre vonatkozó elfeledett szakmai anyagokat, ezen belül dr. Unger Jenő írásait, akinek a '30-asévekben megjelent szakmai publikációi szolgálnak cikkemhez forrásanyagként. Unger Jenő tapasztalt rendőrként és oktatóként a tudós alaposságával járja körül az ilyen eseteket. Alesetekre lebontott részletes útmutatást ad a nyomozó hatóságok számára, hogyan járjanak el az ilyen kényes ügyekben. Tanulmányait a megtörtént esetek leírása teszi színessé és tanulságossá.Mind az Eltűntek nyomozása, mind Az ölési szándék leplezése című munkájában lényeges elem a titkos információgyűjtés, amelyet a nyomozás során puhatolódzásként és megfigyelésként hajtanak végre. Az eltűnések esetében az okok felderítése választ adhat arra a kérdésre, hogy hová távozhatott az, aki eltűnt, ami a szükséges intézkedésekre is kihatással van. Haláleseteknél pedig azt lényeges megvizsgálni, hogy állhatott-e valaki érdekében az elhalálozás. A halál oka lehet természetesnek látszó és természetellenes, de balesetnek tűnő egyaránt.A legsúlyosabb bűneset az emberölés, ezért aki ilyet követ el, azt gyakran leplezni igyekszik. De egy jó rendőrnek mindig gyanakodnia kell, ezért szükséges megvizsgálnia minden erre okot adó körülményt. Mivel olyan eseteket is vizsgálni kell, amelyekről később mégis kiderül, hogy nem történt bűncselekmény, vagy az eltűntek is előkerülhetnek, esetleg maguk is lehetnek tettesek, ezért a nyomozás során körültekintően, részben a titkos információgyűjtés módszereivel kell eljárni.
The Case of Estonia: Educational Internationalization Strategy and Student Mobility
Authors: Fedotov Dmitriy
Published: September 2024

The current article provides an overview of the Estonian higher education system, including its academic and professional branches. It focuses on explaining what has been done in Estonia from 1991 to the present in terms of reshaping the higher education landscape towards a more competitive model that is responsive to the range of needs from quality to equity. To improve the match between education and the needs of labour market and society, Estonia conducts a consistent policy of internationalization in terms of diversity and inclusion. The country tries to get maximum out of its national strengths by focusing on any kind of fields from economy to culture and technology. It clearly defines its internationalization goals and produces highly skilled graduates. Remarkably, the number of international students is on ascending trend in Estonia. The present article evaluates the inflow of degree-mobile international students who choose Estonia as a study destination. It also answers the question of what national educational policies, strategies and economic conditions are and how they help to drive more foreign students into the country.
The Effect of Asynchronous Virtual Exchange on Intercultural Competence among Undergraduate Students
Authors: Chu Curtis , Hooper Todd , Takahashi Mariko , Herke Michael
Published: September 2024

This paper examines whether participating in a five-week asynchronous video exchange program would affect the intercultural competence of undergraduate students at a university in Japan. Participants collaborated with Taiwanese university students on the topic of sustainable tourism and exchanged self-introduction videos, presentations on local tourism, and feedback. A mixed-methods approach was employed in this study. The Intercultural Competence Scale for University EFL Learners was used to gather quantitative data, and participants’ scores were significantly higher in the post-test in four out of five dimensions. As for qualitative data, a survey with open-ended questions was administered to explore how participants perceived the virtual exchange experience. Several themes emerged including communication, culture, and interpersonal interaction, and participants demonstrated traits related to intercultural competence. Findings in this study have provided evidence to support the positive effects of asynchronous video virtual exchange on cultivating intercultural competence among undergraduate students.
The Development of Open Online Courses in China
Authors: OuYang Jiayu , Feng Fei , Wang Qiong , Hu Mengyuan
Published: September 2024

In 2023, China leads the world in  the number of Open Online Courses (OOC, over 64500) and learners (over 1.88 billion). In this article, we provide a brief review of the development of OOCs in China and outline the current situation of Chinese OOC focusing  on learning platforms, course size and structure, and micro-credential courses. We also summarize the development and application of OOC in China  focusing on national policy guidance, the organizational structure of OOCs, different modes of OOC development, and the establishment of a standardized quality assurance system. We also discuss the OOC credit recognition, blended learning, and multi-school collaborative teaching. Finally, we consider the future development trend of OOCs in China from the perspective of improving  digital teaching literacy of instructors and expanding international exchange and cooperation.
Progress and challenges in digital teaching and learning in the Canadian HE system
Authors: Bates Tony Bates
Published: September 2024

Canada has a long history of digital and online learning. The article gives a brief overview of the development of digitalization of teaching and learning in Canadian HE, and the current status in terms of online and blended enrolments across the country, including the impact of Covid-19. The main reasons for this shift in teaching and learning are discussed, as well as the main challenges and opportunities Canadian HE institutions face as a result of the digitalization of teaching and learning. The article ends with conclusions about the extent and type of digitalization, its objectives, and the attitudes and policies of the main stakeholders towards digitalization of teaching and learning in Canadian HE institutions.
RUANG DAN PENDUKUNG KEGIATAN GENI RUMAH BER-TUNGKU API DI DESA GELANG, BANJARNEGARA
Authors: Hermawan Hermawan
Published: September 2024

Kegiatan Geni merupakan satu tradisi yang telah dilakukan oleh masyarakat di Dataran tinggi. Geni atau api menjadi faktor penting dalam kehidupan bermasyarakat. Nilai-nilai api menjadi nilai yang mempunyai banyak fungsi mulai dari fungsi ekonomi, sosial bahkan spiritual. Tradisi geni yang berkembang di masyarakat dataran tinggi tidak hanya dilakukan pada rumah tinggal vernakular tapi rumah modern juga. Tata ruang dan kelengkapan ruang menjadi faktor penentu keberhasilan tradisi Geni. Tujuan penelitian adalah menginvestigasi ruang dan pendukungnya dalam memenuhi keberhasilan tradisi kegiatan geni. Penelitian menggunakan metode kualitatif dengan pengumpulan data dari observasi, wawancara dan dokumentasi. Analisa data menggunakan metode deskriptif. Hasil penelitian menunjukkan bahwa rumah modern tidak terlalu kuat dalam melakukan tradisi geni akibat dari penggunaan kompor gas yang lebih banyak dibandingkan tungku api.
KUALITAS PENCAHAYAAN BUATAN RUANG IBADAH BERBASIS PERANGKAT LUNAK RELUX
Authors: Septyadiani Nurvita , Bramiana Chely Novia
Published: September 2024

Ruang ibadah sebagai ruang utama diharapkan mendapatkan kualitas pencahayaan yang sesuai SNI 03-6197-2000 agar tercipta suasana lebih nyaman untuk beribadah dan agar kenyamanan visual jamaah dapat terpenuhi dengan adanya intensitas pencahayaan yang cukup. Tujuan dari penelitian ini yaitu mendapatkan perancangan pencahayaan memadai pada ruang ibadah Masjid Pangeran Diponegoro menggunakan simulasi perangkat lunak Relux. Metode yang digunakan adalah metode pengukuran dan metode simulasi. Hasil pengukuran langsung dengan lux meter dan simulasi perangkat lunak Relux dengan kondisi aktual sesuai dengan ruang ibadah pria dan wanita pada Masjid Pangeran Diponegoro didapatkan rata – rata masih dibawah 200 lux belum sesuai standar SNI 03-6197-2000,  dengan hasil simulasi Relux ruang ibadah pria dan ruang ibadah wanita sesuai kondisi eksisting adalah 144 lux dan 117 lux, untuk mendapatkan pencahayaan yang sesuai standar SNI 03-6197-2000 yaitu sebesar 200 lux dilakukan simulasi oleh perangkat lunak Relux dengan meningkatkan daya lampu,  merubah warna dinding, serta warna langit-langit menjadi lebih cerah.
ANALISIS ESTETIKA ARSITEKTUR PADA FASAD BAGUNAN PENDIDIKAN (STUDI KASUS: LABORATORIUM TEKNIK 2 ITERA)
Authors: Mantondang Adelia Enjelina , Fajarwati Galuh , Arya Fadhil , Habieb Muhamad
Published: September 2024

Fasad merupakan sebuah bagian terdepan utama eksterior dari sebuah bangunan yang menjadi identitas dari bangunan itu sendiri. Laboratorium Teknik 2 ITERA merupakan sebuah bangunan pendidikan yang menggunakan kaidah arsitektur vitruvius pada bagian fasadnya, sehingga tercipta elemen pembentuk fasad yang menghadirkan estetika dalam bentuknya. Fasad bangunan memiliki bentuk dengan karakteristiknya sendiri sebagai sebuah bangunan dengan elemen-elemen dan ornamen yang ada. Bentuk dan penggunaan ornamen memiliki fungsional yang merespon dengan lokalitas lingkungan bangunan ini berdiri. Bangunan pendidikan LABTEK 2 ITERA mengusung konsep industrial dimana struktur dibiarkan terlihat, seperti balok, baja, kolom dan dinding beton. Konsep ini membuat fungsi dan estetika menjadi berkolaborasi. Pada penelitian ini LABTEK 2 menggunakan elemen-elemen pembentuk pada fasadnya dan memperhatikan nilai-nilai estetika untuk menonjolkan keunikan pada fasadnya.
Senzorska procjena čajnog peciva obogaćenog šipkom (Rosa canina L.)
Authors: Friganović Emilija , Nanjara Ljiljana , Grabovac Anđela , Zvijerac Maria , Dorbić Boris
Published: September 2024

Obogaćeni proizvodi su skupina funkcionalnih prehrambenih proizvoda visoko cijenjenih među potrošačima zbog mogućeg pozitivnog utjecaja na zdravlje. Rosa canina L. raste kao grm na poljima zapadne Azije, Sjeverne Amerike i Europe, a šipak je lažni plod ili pseudokarp vrste Rosa koja pripada obitelji Rosaceae koja dobiva sve više pozornosti zbog svoje visoke nutritivne i ljekovite vrijednosti. Čajno pecivo je popularan i često uživan prehrambeni proizvod te stoga pogodan za obogaćivanje dodavanjem različitih sastojaka. Cilj ovog rada bio je pripremiti uzorke čajnog peciva obogaćenog šipkom (Rosa canina L.) te utvrditi prihvatljivost uzoraka od strane potrošača. U tu svrhu pripremljena su i ocijenjena četiri uzorka čajnog peciva s različitim udjelom osušenog i pulveriziranog šipka u recepturi proizvoda. Podatci dobiveni senzorskom procjenom obrađeni su i analizirani u programima Microsoft Excel i IBM SPSS Statistics 25. Rezultati su prikazani kao aritmetička sredina ± standardna devijacija. U analizi podataka korištena je jednosmjerna analiza varijance (ANOVA) uz Tukeyjev post-hoc test. Čajno pecivo obogaćeno osušenim i pulveriziranim plodom šipka visoko je ocijenjeno od strane potrošača. Iz dobivenih rezultata senzorskog ocjenjivanja može se zaključiti da je najprihvatljiviji uzorak s udjelom od 15 % osušenog i pulveriziranog šipka u odnosu na ukupne suhe sastojke. Podatci pokazuju da za neka senzorska svojstva postoje statistički značajne razlike između uzoraka, posebice za uzorak s najvećim udjelom osušenog i pulveriziranog šipka.
Hrast crnika (Quercus ilex L.) u makiji sjevernodalmatinskih otoka – utjecaj klimatskih i antropogenih čimbenika
Authors: Viličić Damir
Published: September 2024

Primarne šume crnike (Quercus ilex L.) u Sredozemlju su nestale. Sječa šume za poljoprivredu i ispašu, drvo za ogrjev i brodogradnju te požari, degradirali su šume hrasta crnike u šikare - makiju. Na sjevernodalmatinskim otocima ljetna suša je jače izražena nego drugdje u Hrvatskoj što usporava prirast makije s crnikom. Antropogeni utjecaji omogućavaju širenje alepskog bora (Pinus halepensis Miller). Pošumljavanje i sadnja crnike može ublažiti visoku temperaturu i suhoću tla i zraka ljeti, povećati biološku raznolikost, oplemeniti vizualni doživljaj krajobraza, unaprijediti kvalitetu života i zdravlje ljudi i spriječiti eroziju plodnog tla. Do organiziranja nacionalne inicijative, sadnja crnike, koja je karakteristična i stabilizirajuća vrsta klimatogene vazdazelene makije može se provoditi privatnom inicijativom uz suhozidove privatnih posjeda. Otok je dobar eksperimentalni laboratorij za provedbu menadžmenta biološke raznolikosti i zaštite od klimatskih promjena. Dobro bi došla komparativna istraživanja rasta crnike uz istočnu obalu Jadrana.
CORRUPTION AND FINANCIAL SECURITY: ANALYSIS OF SCIENTIFIC BACKGROUND AND SYSTEMIC INTERRELATIONSHIPS
Authors:   Educational and Research Institute of Business, Economics and Management, Sumy State University, Reshetniak Yaroslav , Tarchynets Oleksii ,   Chernihiv Polytechnic National University
Published: September 2024

The article analyzes the trends in search queries and scientific literature for the keywords "corruption" and "financial security" and clusters scientific works in this area to identify future research areas. The analysis of search queries showed that the interest in the term "corruption" is much higher than in the concept of "financial security". In 2011, the greatest interest was related to the opening of criminal cases in many countries (USA, Switzerland, Austria, Brazil) against officials of the International Federation of Football Associations (FIFA), in which they were accused of corruption (in relation to the World Cup in Russia and Qatar), racketeering, fraud and money laundering. A keyword search in the Scopus database revealed 282 publications. The subject matter is quite new, as evidenced by the date of the first publication on the analyzed topic, namely 1992. The top 5 subject areas of publications that published articles on corruption and financial security are: "Social Sciences", "Computer Science", "Economics, Econometrics and Finance", «Engineering, Business, Management and Accounting". The top 5 countries of affiliation of scientists who have studied corruption and financial security include Ukraine (5th place), as well as the United States, China, Russia, and the United Kingdom. The analysis using VOSviewer allowed us to identify 4 clusters of keywords in publications on the topic of corruption and financial security. The first, the largest, united publications analyzing the impact of corruption on the financial security of fragile states and the possibilities of using technologies, including blockchain, to combat this problem. The second largest cluster (green) also includes 9 terms. The third cluster links corruption to financial growth and state security. The fourth cluster is formed by 6 keywords: democracy, elections, organized crime, security, security threats and terrorism.
THE MECHANISM OF MANAGING CHANGES IN CONSUMER MARKET OF UKRAINE CAUSED BY THE WAR (ON EXAMPLE ACTIVITIES OF SE "ADIDAS-UKRAINE")
Authors: Бублик Ліля , Габа Мирослава
Published: September 2024

The war introduced global changes in the functioning of the private sector of the economy, including the primary crisis of the management of private enterprises of Ukraine was the unwillingness to accept global challenges related to the decrease in consumer demand, the need for charitable activities, the destruction of the fixed assets of enterprises and organizations, the fear of losing income, property and own life and health. Businesses faced a choice: continue to work, despite the risks, but wanting to help the state and subordinates by paying wages and tax burden, freeze their own economic activity, close the business. SE "ADIDAS-UKRAINE" chose the second model of behavior, and accordingly, immediately after the start of a full-scale invasion of Ukraine, all wholesale and retail trade establishments were closed, and accordingly, at the end of the year (2022), the company suffered a loss. Therefore, the creation of an effective organizational and economic mechanism for managing the changes caused by the war is very important. Tasks of an organizational and economic nature are social and economic, the first group includes: creation of decent working conditions - will guarantee the involvement of a large number of Ukrainian citizens to work in a company with world recognition; restoration of affected areas of cities and regions - opening of new, reconstruction of old, destroyed shops will contribute to the return of life to previously occupied or mutilated territories; promotion of a healthy lifestyle - thanks to the mass promotion of sports in the war and post-war period, it is possible to avoid depressive states and moods in society; ukrainization - tailoring clothes with national symbols will remind of the identity and uniqueness of the Ukrainian people in Ukraine and abroad; charitable activities - auctions, exhibitions, sales, concern funds, the proceeds of which will be directed to the needs of the army, will contribute to a quick victory over evil. The same economic and economic tasks include: increasing tax revenues - increasing the production and economic capacities of large enterprises directly proportionally affects the amount of revenues to the state treasury; saturation of the consumer market with high-quality goods and services - through the effective functioning of a trading enterprise; increase of jobs and paying citizens - due to the expansion of production to open new points of sale of sports clothes and shoes; increasing demand - by creating loyalty systems, flexible pricing policy.
МЕТОДИЧНІ АСПЕКТИ ФОРМУВАННЯ УПРАВЛІНСЬКОЇ ЗВІТНОСТІ В СУЧАСНИХ УМОВАХ
Authors: Заворітній Микола
Published: September 2024

У статті розглядаються методичні аспекти управлінської звітності в сучасних умовах, зокрема в умовах війни. Нестабільна економічна ситуація, пошкодження інфраструктури та інші виклики вимагають своєчасної і достовірної інформації для ефективних рішень. Автоматизація облікових процесів через цифрові технології зменшує час на підготовку звітів, але потребує значних фінансових вкладень та високої кваліфікації персоналу. Автором виділено кілька підходів до управлінської звітності: інформаційний, функціональний, процесний, системний і стратегічний. Інтегративний підхід дозволяє комплексно оцінювати стан підприємства. Визначено цілі управлінської звітності та складові, що можуть стати достатньою інформаційною основою для управління бізнесом в умовах невизначеності. Розглянуто перспективи використання новітніх технологій, таких як штучний інтелект, хмарні технології, Інтернет речей і блокчейн, для підвищення точності, безпеки та ефективності управлінських процесів. Висновки підкреслюють важливість аналітичних інструментів та необхідність посилення кібербезпеки в умовах цифровізації бізнесу.
ПІДВИЩЕННЯ ЗНОСОСТІЙКОСТІ НАПЛАВЛЕНОГО ПРЕСОВОГО ІНСТРУМЕНТУ ШЛЯХОМ УДОСКОНАЛЕННЯ ПОРОШКОВОГО ДРОТУ
Authors: Бойко Ігор Олександрович , Пашинський Володимир Вікторович , Пашинська Олена Генріхівна
Published: September 2024

Стаття присвячена підвищенню зносостійкості наплавленого пресового інструменту зі сталей 3Х3М3Ф та 38ХН3МФА для екструдування кольорових сплавів шляхом удосконалення порошкового дроту для наплавлення. Розглянуті переваги та недоліки різних класів наплавочних матеріалів і запропоновано використати вдосконалений порошковий дріт марки ПП-45Х5В2ГСМФА. У разі наплавлення самозахисним порошковим дротом легуюча частина цієї сталі забезпечує підвищену твердість за високих робочих температур пресування завдяки комплексному зміцненню мартенситної матриці карбідами вольфраму, хрому й інших елементів, а також додатковому зміцненню нітридом ванадію. Це дозволяє суттєво збільшити ресурс інструменту. Окрім того, легування хромом на рівні 4,5–5% підвищило схоплювання з оброблюваним металом. Розгаростійкість, або термовтомна міцність, наплавленого шару підвищена шляхом підбору й оптимізації газошлакоутворювальних компонентів. Оболонку порошкового дроту трубчатої конструкції виготовлено зі сталі 65Г, що дозволило виключити графіт як вуглець-утворювальний компонент. Це суттєво покращило стабільність плавлення порошкового дроту та зменшило забрудненість наплавленого металу неметалевими включеннями екзогенного характеру. Промислові випробування порошкового дроту ПП-45Х5В2ГСМФА проводились для відновлення та зміцнення матриць для гарячого пресування зі сталі 3Х3М3Ф, прес-шайб з ЕШП-сталі цієї ж марки. Відновлені наплавленням матриці порівняно з новими не наплавленими матрицями показали стійкість у 2,4–2,5 раза вище, а просадка робочого діаметра після 5 циклів пресування зменшилася втричі. Повна вартість відновлення матриці наплавленням в 1,5–2 рази нижче вартості нової матриці зі сталі 3Х3М3Ф. Наплавлення розробленим порошковим дротом прес-шайб дозволило підняти зносостійкість не менше ніж удвічі.
УДОСКОНАЛЕННЯ СИСТЕМИ АСПІРАЦІЇ ТА ГАЗООЧИСНОЇ УСТАНОВКИ НА ДІЛЬНИЦІ КОКСОСОРТУВАННЯ КОКСОВОГО ЦЕХУ
Authors: Галай Володимир Анатолійович , Максимова Наталія Миколаївна
Published: September 2024

На дільницях коксосортування коксових цехів основною проблемою є наявність великої кількості джерел неорганізованих викидів суспендованих твердих частинок, зокрема в місцях пересипу коксу, його сортування, транспортування конвеєрною стрічкою. Результати інструментальних досліджень у місцях інтенсивного пилоутворення на дільниці коксосортування підтвердили фактичну ефективність роботи наявної системи аспірації та газоочисної установки. Виявлена висока запиленість повітря перед входом до групового циклона, а також незначна різниця між вмістом коксового пилу в повітрі робочих зон під час роботи та в разі вимкнення установки очистки газу. Як основний недолік системи аспірації повітря із зон пилоутворення виявлена необхідність транспортування потоку із зазначеною швидкістю, не меншою за мінімально необхідну для роботи групового циклона. Більша частина енергії, необхідної для функціонування димососа, який забезпечує роботу установки очистки газу, витрачається на подолання місцевих гідравлічних опорів, які виникають у газоходах, компенсацію прососів у газоходах, забезпечення швидкості газового потоку, необхідної для нормального штатного режиму експлуатації циклонів. Запропоновано як удосконалення наявної системи аспірації та газоочисної установки на дільниці коксосортування впровадження місцевого пилозахисного укриття з пиловсмоктуючим обладнанням, яке дозволяє повертати уловлений пил у технологічний процес під час регенерації фільтрів. Реконструкція/заміна системи аспірації та газоочисної установки завдяки впровадженню місцевого пиловсмоктувального обладнання на дільниці коксосортування коксового цеху дозволить не лише забезпечити якість повітря, але й підвищити енергоефективість виробництва, що нині набуває все більшої актуальності.
ВИЗНАЧЕННЯ ОПТИМАЛЬНИХ РЕЖИМІВ КОМБІНОВАНОЇ ПЛАСТИЧНОЇ ДЕФОРМАЦІЇ ДЛЯ ОТРИМАННЯ ПОКРАЩЕНИХ МЕХАНІЧНИХ ТА ТЕХНОЛОГІЧНИХ ВЛАСТИВОСТЕЙ МАЛОВУГЛЕЦЕВИХ СТАЛЕЙ
Authors: Пашинська Олена Генріхівна , Пашинський Володимир Володимирович , Бойко Ігор Олександрович
Published: September 2024

У роботі представлено результати впливу комбінованої пластичної деформації на властивості маловуглецевої сталі. Оброблення складається з гарячої прокатки та холодного волочіння, що виконується із застосуванням волок зі зсувом. Експеримент проводили для визначення оптимальних режимів обробки для отримання покращених механічних і технологічних властивостей досліджуваних сталей. Вивчення впливу волочіння зі зсувом на структуру та властивості маловуглецевої сталі здійснювалось за різного поєднання леформування у круглих волоках і волоках зі зсувом. Показано, що застосування волок зі зсувом за різних обтискань і схем волочіння впливає на механічні властивості та густину низьковуглецевого дроту. Визначено оптимальні режими волочіння, установлено, що оптимальним є використання в разі деформації волок зі зсувом за 23% часткового обтиснення. Такий ступінь обтиснення дає мінімальний рівень падіння відносного звуження, що є одним з основних чинників отримання належної технічної деформуємості волочінням, тому з’являється можливість застосовувати таку схему волочіння дроту без використання проміжного відпалу.