bluuebunny/crossref_metadata_2025 huggingface dataset:
So you have heard a heart murmur – what next?
Authors: Hallowell Gayle
Published: March 2023

Heart murmurs are common in horses, This article seeks to help clinicians discern which murmurs are likely to be performance- or safety-limiting and those which are more likely to be physiological. The article will go through some common scenarios and questions raised when a heart murmur is heard - including how it should be Investigated, and whether the horse can be safely sedated or anaesthetised.
Ethics in practice: Schwartz rounds and veterinary clinical ethics committees
Authors: Morrin Hamish
Published: March 2023

Structured approaches to emotional and moral distress, such as Schwartz rounds and clinical ethical committees, are common in human medicine, but less so in veterinary medicine. Although different in their goals, they are both ways to provide organisational structures that support moral resilience. It is possible that, by creating a sense of moral agency and community, these interventions could also help to mitigate moral distress in staff members. Veterinary nurses have an important role to play in developing forums for ethical discussion within practice and the profession. This article discusses the structure and function of both approaches, and looks at what roles veterinary nurses can play in their development and management.
Türk din musikisi formlarından cenâze nevbesi icrasının incelenmesi: Halep örneği
Authors: Erdaş Safiye Şeyda
Published: March 2023

Nevbe, Türk Din Musikisinde son yüzyıla kadar en aktif icra edilen formlardan biriydi. Fakat Cumhuriyet sonrası dönemde Türkiye sınırları içerisinde icrası zamanla unutulmuştur. Buna karşılık Türkiye sınırları dışında aynı medeniyete mensup coğrafyalarda icrasına devam edildiği görülmektedir. Bu çalışmada icra olarak geçmişte kalmış bir form olan nevbeye dair bir örneğin sunulması ve incelenmesi amaçlanmaktadır. Daha çok belirli bir mekânda icra edildiği bilinmekte olan nevbe bu kez hareket halinde ve dış ortamda bir örnek üzerinden ele alınacaktır. Cenaze nevbesinin nasıl icra edildiği sorusu bu araştırmanın ana problemi olarak belirlenmiştir. Bu araştırmada 2011 yılında Halep’te gerçekleşen İbrahim el-Keyyâli’nin cenaze nevbesine ait video kaydı incelenmiştir. Öncelikle nevbenin kaç fasılda icra edildiği ve hangi eserlerin okunduğu tespit edilmiştir. Nevbeye ve özellikle cenaze nevbesine dair yapılan literatür taramasının ardından eldeki bilgiler ışığında canlı performans kaydı değerlendirilmiştir. Okunan şuğuller kayıt elverdiği ölçüde tespit edilmiş, notaya alınmış ve çalışma içerisinde sunulmuştur. Böylece cenaze nevbesine dair icra edilmiş örnek bir repertuvarın sunulması amaçlanmıştır. Yapılan inceleme sonucu bu nevbenin yedi fasıldan müteşekkil olduğu görülmektedir. Bu bölümlendirme Tashîf metnine ve Kerte’ye binaen yapılmıştır. Bu nevbe icrasının diğer nevbe icralarından farklı olduğu gözlemlenmiştir. Cenaze nevbesinin İstanbul’da geçmiş dönemlerde icra edilmiş olduğu bilgisi, Halep’te bu geleneğin günümüze kadar ulaşması ve buna ilave olarak ortak bestelerin varlığını öğrenmek bu iki merkez arasındaki ilişkiye dair örnek ve delilleri çoğaltmaktadır. Sonuç olarak cenaze nevbesine dair bir örneğin ele alınması ve incelenmesi ile bu formun nasıl icra edildiği sorusu cevaplanmış, Osmanlı müzik kültürü ve mirasına yönelik bir inceleme yapılarak alandaki çalışmalara önemli bir katkı sunulmuştur. Bundan sonraki çalışmalar için farklı coğrafyalarda nevbenin icra ediliş şekli incelenerek, nevbe icrası üzerine yapılmış çalışmalarla karşılaştırmalar yapılabilir. Böylece nevbe formu tanım ve içerik olarak artan örnekleri ile zenginlik kazanmış olacaktır. Ayrıca farklı repertuvarlarda Osmanlı müzik kültürüne dair yeni eserler ortaya çıkmış olacaktır.
Building a mechanistic understanding of climate-driven elevational shifts in birds
Authors: Neate-Clegg Montague H. C. , Tingley Morgan W.
Published: March 2023

Mountains hold much of the world’s taxonomic diversity, but global climate change threatens this diversity by altering the distributions of montane species. While numerous studies have documented upslope shifts in elevational ranges, these patterns are highly variable across geographic regions and taxa. This variation in how species’ range shifts are manifesting along elevational gradients likely reflects the diversity of mechanisms that determines elevational ranges and modulates movements, and stands in contrast to latitudinal gradients, where range shifts show less variability and appear more predictable. Here, we review observed elevational range shifts in a single taxonomic group–birds–a group that has received substantial research attention and thus provides a useful context for exploring variability in range shifts while controlling for the mechanisms that drive range shifts across broader taxonomic groups. We then explore the abiotic and biotic factors that are known to define elevational ranges, as well as the constraints that may prevent birds from shifting. Across the literature, temperature is generally invoked as the prime driver of range shifts while the role of precipitation is more neglected. However, temperature is less likely to act directly on elevational ranges, instead mediating biotic factors such as habitat and food availability, predator activity, and parasite prevalence, which could in turn modulate range shifts. Dispersal ability places an intrinsic constraint on elevational range shifts, exacerbated by habitat fragmentation. While current research provides strong evidence for the importance of various drivers of elevational ranges and shifts, testing the relative importance of these factors and achieving a more holistic view of elevational gradients will require integration of expanding datasets, novel technologies, and innovative techniques.
Factors affecting trust in clinical trials conduct: Views of stakeholders from a qualitative study in Ghana
Authors: Chatio Samuel Tamti , Ganle John Kuumuori , Adongo Philip Baba , Beisel Ulrike
Published: March 2023

Evidence exists that scientists’ dehumanization and exploitation of people in the name of science led to suspicion and mistrust in clinical trials conduct. In Ghana, there are equally signs of public distrust in the conduct of biomedical research. Typical examples are the unsuccessful conduct of the Ebola vaccine trial and the initial refusal of parents to allow their children to receive the recently piloted malaria vaccine in Ghana. Therefore, this study explored participants’ views on factors affecting trust in clinical trials conduct in Ghana. This was a cross-sectional exploratory study using qualitative research approach. Forty-eight in-depth interviews and Key informant interviews were conducted with stakeholders. Purposive sampling technique was used to select participants. All the interviews were recorded, transcribed and coded into themes using QSR Nvivo 12 software to aid thematic analysis. Overall, participants saw the need for the conduct of clinical trials in Ghana because clinical trial studies enable scientists to come out with effective medicines for the management of diseases. Pre-implementation factors such as inadequate stakeholder engagement, rumours and negative influence affected trust. Implementation factors such as perceived risks about clinical trials medicines, apprehensions on drawing and use of blood samples, poor informed consent administration and perceived no illness all negatively affected trust in clinical trials conduct. Trust is a fundamental factor affecting a successful conduct of clinical trials. Thus, there is need for collective efforts by all stakeholders including research institutions and clinical trial regulatory bodies to take the issue of trust in clinical trials conduct seriously.
Predicting biomass of resident kōkopu (Galaxias) populations using local habitat characteristics
Authors: Crichton Ben R. J. , Hickford Michael J. H. , McIntosh Angus R. , Schiel David R.
Published: March 2023

With the global decline of freshwater fishes, quantifying the body size-specific habitat use of vulnerable species is crucial for accurately evaluating population health, identifying the effects of anthropogenic stressors, and directing effective habitat restoration. Populations of New Zealand’s endemic kōkopu species (Galaxias fasciatus, G. argenteus, and G. postvectis) have declined substantially over the last century in response to anthropogenic stressors, including habitat loss, migratory barriers, and invasive species. Despite well-understood habitat associations, key within-habitat features underpinning the reach-scale biomass of small and large kōkopu remain unclear. Here, we investigated whether the total biomass of large (> 90 mm) size classes of each kōkopu species and the composite biomass of all small (≤ 90 mm) kōkopu were associated with components of the physical environment that provided refuge and prey resources across fifty-seven 50-m stream reaches. Because kōkopu are nocturnal, populations were sampled by removal at night using headlamps and hand-nets until reaches were visually depleted. Based on Akaike’s information criterion, greater large banded kōkopu biomass was most parsimoniously explained by greater pool volume and forest cover, greater large giant kōkopu biomass by greater bank cover and pool volume, and greater large shortjaw kōkopu biomass by greater substrate size and pool volume. In contrast, greater composite small kōkopu biomass was best explained by smaller substrate size, reduced bank cover, and greater pool volume. Local habitat associations therefore varied among kōkopu species and size classes. Our study demonstrates the importance of considering the ontogenetic shift in species’ habitat use and provides an effective modelling approach for quantifying size-specific local habitat use of stream-dwelling fish.
Individual reflectance of solar radiation confers a thermoregulatory benefit to dimorphic males bees (Centris pallida) using distinct microclimates
Authors: Barrett Meghan , O’Donnell Sean
Published: March 2023

Incoming solar radiation (wavelengths 290–2500 nm) significantly affects an organism’s thermal balance via radiative heat gain. Species adapted to different environments can differ in solar reflectance profiles. We hypothesized that conspecific individuals using thermally distinct microhabitats to engage in fitness-relevant behaviors would show intraspecific differences in reflectance: we predicted individuals that use hot microclimates (where radiative heat gain represents a greater thermoregulatory challenge) would be more reflective across the entire solar spectrum than those using cooler microclimates. Differences in near-infrared (NIR) reflectance (700–2500 nm) are strongly indicative of thermoregulatory adaptation as, unlike differences in visible reflectance (400–700 nm), they are not perceived by ecological or social partners. We tested these predictions in male Centris pallida (Hymenoptera: Apidae) bees from the Sonoran Desert. Male C. pallida use alternative reproductive tactics that are associated with distinct microclimates: Large-morph males, with paler visible coloration, behave in an extremely hot microclimate close to the ground, while small-morph males, with a dark brown dorsal coloration, frequently use cooler microclimates above the ground near vegetation. We found that large-morph males had higher reflectance of solar radiation (UV through NIR) resulting in lower solar absorption coefficients. This thermoregulatory adaptation was specific to the dorsal surface, and produced by differences in hair, not cuticle, characteristics. Our results showed that intraspecific variation in behavior, particular in relation to microclimate use, can generate unique thermal adaptations that changes the reflectance of shortwave radiation among individuals within the same population.
Clonal isolates of Treponema pallidum subsp. pallidum Nichols provide evidence for the occurrence of microevolution during experimental rabbit infection and in vitro culture
Authors: Edmondson Diane G. , De Lay Bridget D. , Hanson Blake M. , Kowis Lindsay E. , Norris Steven J.
Published: March 2023

The recent development of a system for long-term in vitro culture of the syphilis spirochete, Treponema pallidum subsp. pallidum, has introduced the possibility of detailed genetic analysis of this bacterium. In this study, the in vitro culture system was used to isolate and characterize clonal populations of T. pallidum subsp. pallidum Nichols, the most widely studied strain. In limiting dilutions experiments, it was possible to establish cultures with inocula as low as 0.5 T. pallidum per well despite the long generation time (~35 to 40 hours) of this organism. Six Nichols strain clones isolated by limiting dilution were characterized in detail. All clones exhibited indistinguishable morphology and motility, highly similar in vitro multiplication rates, and comparable infectivity in the rabbit model (ID50 ≤ 100 bacteria). Genomic sequencing revealed sequence heterogeneity in the form of insertions or deletions at 5 sites, single nucleotide variations at 20 sites, and polynucleotide (polyG/C) tract length differences at 22 locations. Genomic sequences of the uncloned Nichols strain preparations propagated in rabbits or in vitro cultures exhibited substantial heterogeneity at these locations, indicating coexistence of many varied ‘clonotypes’ within these populations. Nearly all genetic variations were specific for the Nichols strain and were not detected in the >280 T. pallidum genomic sequences that are currently available. We hypothesize that these Nichols strain-specific sequence variations arose independently either during human infection or within the 110 years since the strain’s initial isolation, and thus represent examples of microevolution and divergence.
Determinants of bank’s efficiency in an emerging economy: A data envelopment analysis approach
Authors: Ullah Saif , Majeed Abdul , Popp József
Published: March 2023

This study aims to assess the influence of internal and external factors on the Efficiency of banks in Pakistan using the Data Envelopment Analysis Approach (DEA). Bank’s Efficiency is measured through DEA Model using input and output variables. The input variable includes the number of employees, number of branches, administration expenses, non-interest expenses, and loan loss provisions. In contrast, the output variable consists of net interest income, net commissions, and total other income. This study considers the internal determinants of the bank’s Efficiency as corporate governance, enterprise risk management, ownership structure (state, foreign, and domestic ultimate owned banks), return on equity, financial leverage, and the size of the bank. The external determinants of the bank’s Efficiency include banking structure and macroeconomic conditions. The study has used data from seventeen commercial banks over the period of 2011 to 2020. The study used the Data Envelopment Analysis Approach (DEA) and Logit and Probit Regression Model to evaluate research hypotheses. The Logit model results show that corporate governance, ultimate global ownership, and return on equity have a statistically significant and positive impact on the bank’s Efficiency. Enterprise risk management and financial leverage adversely affect the bank’s Efficiency. Better corporate governance can help banks to control the risk and cost of capital and enhancement the effectiveness of capital. Similarly, better risk management of banks can lead to better operational and strategic decisions in the competitive banking environment.
How food support improves mental health among people living with HIV: A qualitative study
Authors: Chayama Koharu Loulou , Hufstedler Emiliano Lemus , Whittle Henry J. , Nápoles Tessa M. , Seligman Hilary , Madsen Kimberly , Frongillo Edward A. , Weiser Sheri D. , Palar Kartika
Published: March 2023

Background

Food insecurity is associated with poor mental health among people living with HIV (PLHIV). This qualitative study explored the mental health experiences of PLHIV participating in a medically appropriate food support program.

Methods

Semi-structured interviews were conducted post-intervention (n = 34). Interview topics included changes, or lack thereof, in mental health and reasons for changes. Interviews were audio-recorded, transcribed, and double-coded. Salient themes were identified using an inductive-deductive method.

Results

Positive changes in mental health self-reported by PLHIV included improved mood and reduced stress, worry, and anxiety. Participants attributed these changes to: 1) increased access to sufficient and nutritious foods, 2) increased social support, 3) reduced financial hardship, 4) increased sense of control and self-esteem, and 5) reduced functional barriers to eating.

Conclusions

Medically appropriate food support may improve mental health for some PLHIV. Further work is needed to understand and prevent possible adverse consequences on mental health after programs end.
Államilag elismert nyelvvizsgák tudományos feldolgozottsága magyarországi alkalmazott nyelvészeti és pedagógiai szakfolyóiratokban
Authors: Kiszely Zoltán
Published: March 2023

Az államilag elismert nyelvvizsgáztatás Magyarországon több mint 20 éves múltra tekint vissza. Az eltelt idő alatt rengeteg tapasztalat gyűlt össze a vizsgaközpontok és a vizsgarendszerek működésével kapcsolatban. A központokban folyó szakmai munka és az akkreditációs előírások folyamatos fejlesztése együttesen járult hozzá az idegennyelvi mérés és értékelés korábban nem látott mértékű fejlődéséhez. Ez a fejlődés többnyire a tudományos feldolgozottság tekintetében is tükröződik: a vizsgáztatásról számos tanulmány jelent meg helyi, elsősorban egyetemi kiadványokban és konferenciakötetekben, doktori disszertációk is születtek ebben a témában, valamint külföldi konferenciákon is hangzottak el előadások. Jelen cikk azonban kizárólag azokat a tanulmányokat vizsgálja, amelyek a legnagyobb presztízsű magyarországi alkalmazott nyelvészeti és pedagógiai folyóiratokban jelentek meg 2000 és 2020 között. Jelen tanulmány első célja tehát ezeknek a tanulmányoknak az összegyűjtése, rendszerezése és elemzése. A második cél, hogy ezen tanulmányok tükrében áttekintést nyújtson a magyarországi akkreditált nyelvvizsgáztatás fejlődéséről, aktuális állapotáról, a szakembereket foglalkoztató kérdésekről és mindezek változásairól a vizsgált 20 év során. Végül pedig a meglévő tanulmányok elemzése alapján felhívja a figyelmet néhány további potenciális kutatási területre.
Tanárszakos hallgatók adathasználattal kapcsolatos hatékonyság- és szorongásérzete
Authors: Sebestyén Edmond , Tóth Edit
Published: March 2023

A pedagógiai információk szisztematikus gyűjtése, elemzése, értelmezése és alkalmazása a tanítási-tanulási folyamat fejlesztése érdekében egyre növekvő figyelmet kap a neveléstudományi kutatásokban. A pedagógusok ezen komplex adathasználatának megalapozása a tanárképzésben kezdődik. Kutatásunkban a tanárképzésben részt vevő hallgatók (N = 221) adathasználattal – hozzáférés, elemzés, értelmezés és alkalmazás – kapcsolatos hatékonyság- és szorongásérzetét vizsgáljuk a Data-Driven Decision-Making Efficacy and Anxiety (Dunn és mtsai, 2013) kérdőívvel. Vizsgáljuk továbbá az adathasználatban megszerzett tudás és a hatékonyság-, szorongásérzet közötti kapcsolatot. Eredményeink szerint a hallgatók leginkább az adatfeldolgozás terén érzik legkevésbé hatékonynak magukat, de az értelmezés kérdéseiben is bizonytalanabbak, mint az eredmények alkalmazása terén. Szorongásérzetük az adathasználattal kapcsolatban alacsony. Nem mutatható ki különbség az adathasználattal kapcsolatos hatékonyság- és szorongásérzetben a képzésben eltöltött idő alapján. Ugyanakkor az adathasználathoz való viszonyulást befolyásolja az, hogy a hallgató milyen, az adathasználatban való jártasságot támogató kurzus(ok)on vett részt. Tehát a képzés során szerzett ismeretek vélhetően növelik a hallgatók hatékonyságérzetét és csökkentik szorongását az adatok használatával összefüggésben.
A gazdaság megváltozott, a gazdaság megváltoztatott
Authors: Lits Levente , Lits Benedek
Published: March 2023

A Világpolitika és Közgazdaságtan folyóirat indulásakor egy háromrészes kirakó elemeit bátorkodtunk sorra venni az Orosz-Ukrán konfliktus nyomán. Elsőként az értékek párbeszédének folyamataiban kerestük a megbékélés vonulatát a karbonpolitika színterén, mely a megváltozó világrend, a változó világ politikája. Másodszor azt kibontva, annak tudására, a politikai tudás működésére kérdeztünk rá egyértelművé téve a fennmaradás és a jelenlét közös ügyét, ami egyet jelent napjainkban a társadalmi igazságosság kiküzdésével. Cikksorozatunk harmadik és egyben utolsó részeként pedig a politikai unió és a gazdaság határainak, kialakulásának és kapcsolódásainak vizsgálatára helyezzük a hangsúlyt Theodorosz Angelopoulosz Odüsszeusz tekintete című filmjében szereplő három, messzemenőkig szövevényes és integrált fogalmának segítségével.
„A szereplők nem gondolkodhatnak úgy, mint a volt gyarmatosítók.” – beszélgetés Afrika gazdasági fejlődéséről
Authors: Tarrósy István
Published: March 2023

A Világpolitika interjút kért dr. Tarrósy Istvántól, a PTE egyetemi tanárától, a PTE-n működő Afrika kutatóközpont igazgatójától. Tarrósy István Az MTA Afrika Albizottságának titkára, a Pécs African Studies kétévenként megrendezésre kerülő nemzetközi szakkonferencia elindítója, szervezője. Számos hazai és külföldi szakfolyóirat szerkesztője. A beszélgetést Horváth Anna és Trautmann László készítette.
Reziliencia, klímakockázat üzleti vonatkozásai : Interjú Cserényi Dórával, Czakó Karolinával, Reizinger Zsófiával és Veisz Ákossal, a BDO Magyarország szakértőivel
Authors: Cserényi Dóra , Czakó Karolina , Reizinger Zsófia , Veisz Ákos
Published: March 2023

A klímaváltozás gazdasági, üzleti kérdés is, számos kockázati tényezőt rejt magában. A Köz-gazdaság 2022/4-es számában megjelent Cserényi Dóra, Czakó Karolina, Reizinger Zsófia és Veisz Ákos, mindannyian a BDO Magyarország szakértőinek ezzel foglalkozó tanulmánya, ami alapján interjút kértünk a szerzőktől. A tanulmányt itt olvashatják: http://retp.eu/index.php/retp/article/view/1474/1386
A „Global Gateway” kezdeményezés és az Európai Unió digitális ambíciói
Authors: Füredi Anita
Published: March 2023

Forrás: Marta Granados Hernandez: Global Gateway and the EU’s Digital Ambitions, eredetileg megjelent: Center for Strategic & International Studies 2022 A globális digitális transzformáció folyamatában az Európai Unió az utóbbi évek óta egyre nagyobb szerepet szeretne vállalni. A transzformáció középpontja az afrikai kontinens. A 2022 februárjában megtartott Európai Unió – Afrikai Unió 6. csúcstalálkozója (6th European Union–African Union Summit) alapján az EU jelentős pénzügyi támogatási csomagot ígért az afrikai kontinens számára az energetika, a közlekedés, az egészségügy, az oktatás és a digitalizáció fejlesztése érdekében. A támogatást a „Global Gateway” kezdeményezés részeként értelmezhetjük, és elsősorban infrastrukturális projektek kivitelezésére fordítják majd. A zöld és digitális területeket érintő beruházások célja a transzatlanti konvergencia előmozdítása a B3W (Build Back Better World) G7 kezdeményezéssel karöltve, ezáltal alternatív választ adni Kína globális változásokat kialakító kezdeményezésire (pl. Egy Övezet Egy Út Kezdeményezés).
Morphology of the brain base arteries of the giant anteater (Myrmecophaga tridactyla)
Authors: Oliveira Kleber Mirallia de , Mirallia Yohana Heloise , Silva Daniel Barbosa da , Moreira Paulo César , Qualhato Gabriel , Figueiredo Augusto Cesar Ribeiro , Guimarães Nilza Nascimento , Cardoso Júlio Roquete
Published: March 2023

This study aimed to describe the brain base arteries of the Myrmecophaga tridactyla using ten cadavers of adults from this species, including five male and five female specimens. The arterial vascular bed was perfused via the thoracic aorta with a dyed natural latex solution, and the animals were fixed and preserved with a 10% formaldehyde buffered solution. The encephala were removed, and their vessels dissected. Basilar artery formation occurred by anastomosis of the thick ventral spinal artery with vertebral arteries. The basilar artery formed two arterial islands and gave bulbar and pontine branches, and cranial, middle, and caudal cerebellar arteries and ended by forking into its terminal branches, the caudal communicating arteries. The blood supply of the encephalon derived solely from the vertebrobasilar system, and the arterial circle of the brain was closed caudally and rostrally. The absence of participation of internal carotid arteries in encephalon irrigation, the island formations by the basilar artery, and the fusiform shape of the arterial circle of the brain are peculiar characteristics of the vascular anatomy of the brain base of M. tridactyla.
Sugarcane and Coffee in the Extreme Southern Region of Bahia, Brazil: A Spatio-Temporal Analysis and Socioeconomic Factors
Authors: Almeida Regiane Oliveira , Cruz Thyane Viana , Crepaldi Maria Otávia , Silva Leonardo Thompson , Sousa Ana Cristina , Cerqueira Everton Mateus Santos , Sena Anderson
Published: March 2023

The região extremo sul da Bahia(RESB-Extreme Southern Region of Bahia) hasagricultural aptitude for several crops and has already been subjected to the expansion of sugarcane and coffee. Thus, this work analyzes the spatial and temporal dynamics of sugarcane and coffee monocultures in the RESB and their relationship with socioeconomic indices. The methodology consists of collection and analysis of data from the Instituto Brasileiro de Geografia e Estatística (IBGE), which is the main provider of geographic information and statistics in Brazil,the Companhia Nacional de Abastecimento(CONAB), which is responsible for providing technical information to support decision-making regarding the elaboration of policies aimed at agricultureand the Atlas Brasil platform. Data were collected regarding the planted area and the amount of sugarcane and coffee produced in the region between 1988 and 2019. To understand the relationship between expansion and socioeconomic factors, data related to gross domestic product (GDP) and municipal human development index (MHDI) were collected. This study identified the main sugarcane-producing municipalities (Caravelas, Mucuri, Medeiros Neto, Nova Viçosa, Lajedão, Ibirapuã and Santa Cruz Cabrália) and coffee (Prado, Itamaraju, Porto Seguro, Eunapolis, Teixeira de Freitas and Itabela). The expansion of these crops presents economic importance for the region, but presents a little contribution to the improvement of the various factors that make up the MHDI of the municipalities. This study concluded that the expansion of these crops changed the agricultural matrix of the region due to its specialization in the production of these crops to the detriment of others such as cocoa, for example.
Cómo abordar el cáncer infantil en el entorno escolar
Authors: Redolosi Sánchez Ester
Published: March 2023

Algunos docentes se encuentran con alumnos diagnosticados de cáncer en sus aulas. Aprender a gestionar la situación y tener los recursos emocionales es fundamental puesto que ayudarán a que el alumno y su familia puedan afrontar la situación de forma adaptada y que el proceso de enseñanza-aprendizaje se vea lo menos afectado posible. En este artículo se proponen algunas pautas y estrategias que facilitan la labor del entorno educativo ante esta enfermedad.
El agente topo
Authors: Gutiérrez Moar M.ª Carmen , Pereira Domínguez Carmen
Published: March 2023

Rómulo, un detective privado, recibe el encargo de una clienta interesada en averiguar si su madre —que vive en una residencia de personas mayores— está bien cuidada y con una atención médica satisfactoria, o si es víctima de maltrato, golpes o robo.

Para llevar a cabo la misión selecciona, contrata y entrena a Sergio como investigador, un hombre, enviudado recientemente, de 83 años que debe infiltrarse en el centro durante 90 días como un “agente topo”. Mientras, Sergio pone empeño en cumplir su función, para ello se entrena en el manejo del teléfono móvil y de las cámaras ocultas en las gafas y bolígrafos. Además, perfecciona su comportamiento para evitar sospechas y no descubrir su tapadera.

A medida que Sergio ejerce su rol de espía, inevitablemente, se va convirtiendo en un aliado del entrañable grupo de residentes hasta el punto de involucrarse en la vida de todas esas personas, esto es, cuarenta mujeres y cuatro hombres, dejando en todos ellos una huella imborrable.
Education Policy Actions by the Ministry of National Education after the Earthquake Disaster on February 6, 2023 in Türkiye
Authors: ÖZER Mahmut
Published: March 2023

One of the largest earthquake disasters in Turkish history occurred on February 6, 2023. The earthquakes impacted ten provinces greatly, which increased its destructive effect. Immediately following the earthquakes, the Ministry of National Education (MoNE) began providing education services and humanitarian assistance. By utilizing its human resources and production capacity, the MoNE was able to mitigate the effects of the earthquakes. The purpose of this study is to assess the support provided by the MoNE to the continuation of education services after the earthquakes as well as assistance to the citizens affected by the disaster, taking into account the global frameworks. It was observed that MoNE institutions played a major role in providing humanitarian assistance in the earthquake area. MoNE has taken on the majority of the production and distribution of food, shelter, and heating. To ensure that education services are provided as quickly as possible, the MoNE has developed education areas and appointed teachers and psychological counselors. As education services were rapidly launched through tents, containers, and prefabricated schools; preparations were made for the transition to face-to-face education. Students were able to continue their education during the course of their treatment in hospital classes. The transfer for students who wish to study in other cities was facilitated and free boarding facilities were provided. Based on the guidelines for education in emergencies frameworks by INEE and UNESCO-IIEP, it may be concluded that the MoNE effectively implemented the suggested policies for the continuation of education, and utilized its experience in the Covid-19 outbreak in providing social assistance.
Improving Administrative Proceedings
Authors: Janowicz Zbigniew
Published: March 2023

The paper is an English translation of “Uwagi o doskonaleniu postępowania administracyjnego” by Zbigniew Janowicz published originally in Państwo i Prawo in 1978. The text is published as a part of a section of the Adam Mickiewicz University devoted to the achievements of the Professors of the Faculty of Law and Administration of the Adam Mickiewicz University, Poznań.
European Standard for the Protection of Patients’ Lives
Authors: Kwiatkowski Paweł
Published: March 2023

The aim of the study it to reconstruct the European standard for the protection of patients’ lives in its substantive and procedural aspects. In the case-law of the bodies of the system of the Convention for the Protection of Human Rights and Fundamental Freedoms, the scope of the state authorities’ substantive and procedural obligation to protect the right to life in the health care system was defined for the first time by the European Commission of Human Rights in the decision of 22 May 1995 in Mehmet Işıltan v. Turkey, and then repeated in the case-law of the reformed Court in the decision on the admissibility in Powell v. United Kingdom. The study of the European standard for the protection of patients’ lives traces its history, from Mehmet Işıltan v. Turkey and Powell v. United Kingdom; through developments of the meaning of its substantive limb, as illustrated by Mehmet and Bekir Senturk v. Turkey, Asiye Genc v. Turkey, Aydogdu v. Turkey, and Elena Cojocaru v. Romania; to developments of the meaning of its procedural limb, as exemplified by Calvelli and Ciglio v. Italy, Wojciech Byrzykowski v. Poland, Šilih v. Slovenia, and Gray v. Germany; and finally covers the Court’s attempt to sum up its previous approach to the European standard for the protection of patients’ lives, as expressed in the case of Lopes de Sousa Fernandes v. Portugal.
Evidence From Artificial Intelligence in General Administrative Procedure
Authors: Dubiński Łukasz
Published: March 2023

Artificial intelligence is becoming an element of everyday life, and also a part of administrative proceedings. The legislator systematically adds regulations that allow public administration bodies to use artificial intelligence. At the same time, the Code of Administrative Procedure has not been amended in this respect. The article tries to establish what artificial intelligence evidence is. In addition, the issue of whether the rules on administrative evidence should be changed to cover the use of AI evidence is examined.
Synthesis, characterization, anticancer, anti-inflammatory activities, and docking studies of 3,5-disubstituted thiadiazine-2-thiones
Authors: Ali Haleema , Khan Rasool , Pan Xiandao , Shaheen Farzana , Jabeen Almas , Rauf Abdur , Shah Muhammad , Rashid Umer , Al-Awthan Yahya S. , Bahattab Omar S. , Al-Duais Mohammed A. , Mubarak Mohammad S.
Published: March 2023

In the search for potent bioactive compounds, a series of tetrahydro-2H-1,3,5-thiadiazine-2-thiones (1–13) were synthesized in good yield and characterized by means of 1H NMR, 13C NMR, and mass spectral data. The anticancer activity of the compounds was evaluated against HeLa cell line and anti-inflammatory potential via nitric oxide (NO) inhibition. Among the screened compounds, 2-(5-(3-methoxypropyl)-6-thioxo-1,3,5-thiadiazinan-3-yl) propionic acid (3), 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl) propionic acid (5), 2-(5-cyclopropyl)-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid (6), and 2-(5-butyl-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid (9) were the most potent against HeLa cell line with IC50 values <4 µM, whereas the rest of the series exhibited moderate-to-good activities. All the compounds were potent NO inhibitors with IC50 values ranging from <0.4 to 14.9 µM. Docking studies, binding orientations, and interaction plots showed strong interaction of the studied compounds with the inducible NO synthase enzyme via strong hydrogen bonds and hydrophobic interactions, which authenticate the in vitro results. These newly synthesized compounds could lead to the discovery of anticancer drugs.
Scaling effect on cesium diffusion in compacted MX-80 bentonite for buffer materials in HLW repository
Authors: Liu Yi-Ling , Lin Tzu-Ting , Lee Chuan-Pin
Published: March 2023

In this study, radionuclide behavior in high-level radioactive waste (HLW) disposal repositories is complicated because of the spatial heterogeneity of porous media, coupled flow-transport mechanisms, and multiple chemical reaction processes. Discrepancies in the diffusion behavior of a non-sorbing tracer (HTO) and a reactive tracer (137Cs) in porous media have long been recognized but are not yet fully understood, which hinders effective assessment of the capabilities of buffer materials. This paper was dedicated to exploring and explaining the discrepancies in the transport behavior of non-sorbing and reactive tracers through laboratory experiments and an investigation of contributing mechanisms. Our results showed that for a bentonite sample of the same thickness, 137Cs has smaller apparent and less effective diffusion coefficients than those for HTO. These discrepancies can be attributed to the negative surface electric effects, atomic properties, and chemical reactions. In the case of bentonite samples with different thicknesses (0.5, 0.75, 2.0, 2.5 cm), the apparent and effective diffusion coefficients show an increasing trend with bentonite thickness. According to the experimental data and fitting results, the apparent and effective diffusion coefficients are highly related to bentonite thickness. Thus, scaling effects on transport parameters were proposed to explain the results, which were attributed to the nonuniform distribution of the pore space in the bentonite sample. The scale effect behavior of radionuclide was quantified through a regression analysis. The results can be used to improve buffer designs for radionuclides diffusion.
Some results on the value distribution of differential polynomials
Authors: Fan Jinyu , Xiao Jianbin , Fang Mingliang
Published: March 2023

In this article, we study some results on the value distribution of differential polynomials and mainly prove the following theorem: suppose that

P

P

is a polynomial with

deg

P
≥
3

{\rm{\deg }}\hspace{0.33em}P\ge 3

and

f

f

is a transcendental meromorphic function. Let

α

\alpha

be a small function of

f

f

. If

α

\alpha

is a constant, we also require that there exists a constant

A
≠
α

A\ne \alpha

such that

P

(

z

)

−
A

P\left(z)-A

has a zero of multiplicity at least 3. Then, for any

0
<
ε
<
1

0\lt \varepsilon \lt 1

, we have

T

(

r
,
f

)

≤
k

N

¯

r
,

1

P

(

f

)

−
α

+
S

(

r
,
f

)

,

T\left(r,f)\le k\overline{N}\left(r,\frac{1}{P(f)-\alpha }\right)+S\left(r,f),

where if

P
′

(

z

)

P^{\prime} \left(z)

has only one zero, then

k
=

1

deg

P
−
2

k=\frac{1}{{\rm{\deg }}\hspace{0.33em}P-2}

; if

P
′

(

z

)

P^{\prime} \left(z)

has two distinct zeros

a

a

and

b

b

with

P

(

a

)

≠
P

(

b

)

P\left(a)\ne P\left(b)

and

α

\alpha

is nonconstant, then

k
=

1

1
−
ε

k=\frac{1}{1-\varepsilon }

; otherwise

k
=
1

k=1

.
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA
Authors: Ngo Jennifer , Choi Dong Wook , Stanley Illana A , Stiles Linsey , Molina Anthony J A , Chen Pei‐Hsuan , Lako Ana , Sung Isabelle Chiao Han , Goswami Rishov , Kim Min‐young , Miller Nathanael , Baghdasarian Siyouneh , Kim‐Vasquez Doyeon , Jones Anthony E , Roach Brett , Gutierrez Vincent , Erion Karel , Divakaruni Ajit S , Liesa Marc , Danial Nika N , Shirihai Orian S
Published: March 2023

Changes in mitochondrial morphology are associated with nutrient utilization, but the precise causalities and the underlying mechanisms remain unknown. Here, using cellular models representing a wide variety of mitochondrial shapes, we show a strong linear correlation between mitochondrial fragmentation and increased fatty acid oxidation (FAO) rates. Forced mitochondrial elongation following MFN2 over‐expression or DRP1 depletion diminishes FAO, while forced fragmentation upon knockdown or knockout of MFN2 augments FAO as evident from respirometry and metabolic tracing. Remarkably, the genetic induction of fragmentation phenocopies distinct cell type‐specific biological functions of enhanced FAO. These include stimulation of gluconeogenesis in hepatocytes, induction of insulin secretion in islet β‐cells exposed to fatty acids, and survival of FAO‐dependent lymphoma subtypes. We find that fragmentation increases long‐chain but not short‐chain FAO, identifying carnitine O‐palmitoyltransferase 1 (CPT1) as the downstream effector of mitochondrial morphology in regulation of FAO. Mechanistically, we determined that fragmentation reduces malonyl‐CoA inhibition of CPT1, while elongation increases CPT1 sensitivity to malonyl‐CoA inhibition. Overall, these findings underscore a physiologic role for fragmentation as a mechanism whereby cellular fuel preference and FAO capacity are determined.
Mutation spectrum and frequency of copy number variations of the ANOS1 gene in patients with Kallmann syndrome or normosmic isolated hypogonadotropic hypogonadism
Authors: Hye Kim Ja , Choi Yunha , Hwang Soojin , Yoon Ji-Hee , Lee Jieun , Jae Kang Min , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho
Published: March 2023

Objective

This study was performed to investigate the molecular characteristics and frequency of copy number variations (CNVs) of ANOS1 in patients with Kallmann syndrome (KS) or normosmic isolated hypogonadotropic hypogonadism (nIHH) using multiplex ligation-dependent probe amplification (MLPA) analysis and sequencing.

Methods

Among 45 patients from 43 independent families, Sanger sequencing, next-generation sequencing (NGS), or microarray was performed in 24 patients from 23 families, and MLPA was performed in 19 patients who did not show rare sequence variants (n = 18) or ANOS1 amplification by PCR (n = 1).

Results

Seven patients (four patients with KS, one patient with nIHH, one prepubertal boy with anosmia, and one newborn patient) from six families (6/43, 14%) harbored molecular defects in ANOS1 including a nonsense mutation (c.1140G>A (p.W380*)), a frameshift mutation (c.1260del (p.Q421Kfs*61)), a splice site mutation (c.1449+1G>A), an exon 7 deletion, a complete deletion, and 7.9 Mb-sized inversion encompassing ANOS1. The complete deletion of ANOS1 was identified in a neonate with a micropenis and cryptorchidism. Unilateral renal agenesis was found in three patients, whereas only one patient displayed both synkinesia and sensorineural hearing loss. There was no reversal of hypogonadotropic hypogonadism in any patient during 9.1 ± 2.9 years of treatment with testosterone enanthate.

Conclusions

Molecular defects in the ANOS1 gene could be identified in 14% of probands including various types of CNVs (3/43, 7.0%). Comprehensive analysis using sequencing and analysis for CNVs is required to detect molecular defects in ANOS1.
VALUE-FORMING CONCEPT OF EDUCATION OF PERSONALITY OF A SCHOOL STUDENT IN INDEPENDENT UKRAINE
Authors: Lemko Halyna , Didukh Iryna , Voroshchuk Oksana
Published: March 2023

The current period of social development is characterized by important processes that take place in the student environment. Under the influence of various social and political factors, new forms of thinking appear, specific values and value orientations are formed. The formation of value orientations among schoolchildren becomes particularly acute in modern society, which today is characterized by social instability, a crisis of spirituality, morality, and neglect of legal norms. Such a situation brings to the fore the problems of forming a new person, their consciousness and self-awareness, life values, spiritual forces, opportunities and abilities. In pedagogical science, the concept is interpreted as a system of views, which is significantly different from its theory or methodology due to the fact that the concept cannot be a finally verified constructor. It needs constant refinement, its theses can be debatable and require verification by facts, require the formulation of trends and regularities. The article analyzes the leading regulatory and legal documents containing relevant provisions on the foundations of the value-forming concept of personality education: State national program "Education" ("Ukraine of the 21st century"), The Law of Ukraine "On Education", the National Strategy for the Development of Education of Ukraine for the period until 2021, Concept of national education of student youth, Program of Ukrainian patriotic education of children and student youth, The concept of the New Ukrainian School, the regional targeted social program of national-patriotic education of children and youth for 2021-2025, approved by the Ivano-Frankivsk Regional Council. We also highlighted the relevance of building and implementing the concept of raising children and youth, highlighted the purpose of the concept of raising children and youth, and characterized the main principles of building the concept.

Keywords: concept, values, education, schoolchildren, value-forming concept.
ORGANIZATIONAL AND PEDAGOGICAL CONDITIONS OF MANAGEMENT OF THE EDUCATION OF FUTURE TEACHERS IN THE CONDITIONS OF DIGITALIZATION OF EDUCATION
Authors: Prokopenko Alona
Published: March 2023

A scientific study of the educational process of future teachers (FT) in the conditions of digitalization of education directs the author to the need to study the issue of implementing the management of the educational process. To solve this issue, it is necessary to investigate the problem of ensuring organizational and pedagogical conditions and highlight the author's vision of solving this problem. It is carried out the study and analysis of scientific research by domestic and foreign scientists regarding the understanding of the problem of pedagogical and organizational-pedagogical conditions for ensuring the educational process of FT, and the organization of these conditions during the digitalization of the educational space of higher education. The author states that the process of organizing and managing the education of future teachers should include several features. Among them, the following are highlighted: the motivational and age component, which is aimed at the activity and purposefulness of FT during education; interaction with stakeholders who put forth actual requirements for the competitiveness of graduates, as well as adjust educational programs accordingly, contribute to the deepening of the expected results of the education of FT; taking into account the peculiarities of the conditions of digitization of education, which are related to the formation of the readiness of FT to use informational and communicative means of education in their future professional activities. The article examines two organizational and pedagogical conditions for managing the education of FT in the modern conditions of digitization of higher education, namely, the modernization of the management cluster and ensuring the effectiveness of the student-centered environment. It is determined that these conditions are based on the formation of practical experience of each future specialist who is ready for the educational and scientific challenges of the present time, and is also capable of self-education in the conditions of digitalization. Thus, these organizational and pedagogical conditions contribute to the provision of productive management of the education of FT in the conditions of digitalization of education.

Keywords: conditions, digitalization, digitalization of education, future teacher (FT), education, management, management education.
STUDENT-CENTERED APPROACH IN THE SYSTEM OF QUALITY ASSURANCE OF PROFESSIONAL TRAINING OF FUTURE PROFESSIONALS
Authors: Iliichuk Liubomyra
Published: March 2023

In the current conditions of development of higher education in Ukraine the question of realization of the idea of student-centeredness as a necessary component of the system of quality assurance of professional training of future specialists is actualized. The article considers the peculiarities of the student-centered approach as a system-forming principle of the organization of the educational environment of a higher education institution in the conditions of modern educational realities. The main ideas of student-centeredness as an approach to the organization of the educational process in accordance with its components, defined by the Law of Ukraine «On Higher Education» are analyzed and systematized. Procedures for implementing a student-centered approach in accordance with the requirements of Standards and Recommendations for Quality Assurance in the European Higher Education Area are considered. A contextual analysis of student-centeredness as a characteristic feature of higher education is carried out, on the basis of which the social (civilizational), philosophical, social, psychological, pedagogical, managerial and personal aspects of this phenomenon are distinguished. The need to create an educational environment focused on meeting the needs and interests of higher education students has been identified. The role of the idea of student-centeredness in designing the educational environment of a higher education institution is revealed. It was found that the student-centered educational environment is a set of interrelated diverse conditions for the realization of educational needs and interests of students, which includes a system of intellectual and communicative, organizational, educational, informational, technological, material and technical resources. It is emphasized that the implementation of student-centered approach outlines ways to design the educational environment of a modern university, focused on continuous development and self-improvement of future professionals, which is a necessary condition for ensuring the quality of higher education in Ukraine.

Keywords: student-centeredness, student-centered approach, educational process, educational environment, professional training, quality of higher education.