bluuebunny/crossref_metadata_2025 huggingface dataset:
Spectroscopic Analysis of Tempeh Protein Content during the Production Process
Authors: Arham Zul , Kurniawan Kurniawan , Anhusadar Laode , Ismaun Ismaun
Published: January 2023

Tempeh is a local Indonesian food that is liked by the community, both locally and internationally. The high protein content is the reason for choosing tempeh as a complementary food. In its production, tempeh is made by two important processes, including treatment and fermentation. During this process, the protein can be damaged, resulting in a decrease in the protein content of tempeh. Based on these problems, this study aims to analyze the reduction of tempeh protein content during the production process. The analysis used two spectroscopic methods, including FTIR and UV-Visible. FTIR spectroscopy was used to observe the reduction in total protein content, while UV-Vis spectroscopy was used to observe the reduction in dissolved protein content. The results of the study for FTIR analysis showed that at the pretreatment and fermentation stages, both caused a decrease in the total protein content of tempeh. This was observed with a decrease in the intensity of IR absorption at a wavenumber of 1745 cm-1 which is identical to the C=O group and 1543 cm-1 which is identical to the N-H group. Based on the results of the UV-Visible study, it shows that the fermentation time affects the amount of dissolved protein. This situation is supported by the increasing pH of tempeh and decreasing water content during fermentation.
Memahami Konstruksi Nalar Epistemologi Etnik: Sebuah Kajian Filosofis
Authors: Manurung Elvy Maria , Purwadi Yohanes Slamet , Sugiharto Ignatius Bambang
Published: January 2023

In the 21st century, due to its incessant auto-criticism, the orientation of science is split into two. On the one hand, the monolythic tendency of positivism -with its physicalistic paradigm- is still prevalent. On the other, the tendency of openess toward the complexity of reality is also thriving. The latter would include the openess toward non physical variables or even toward esoteric experience. At this junction, the concept of
ethnoepistemology is worth considering. With regard to this, this article seeks to see the fundamental differences between the universal-scientific epistemology and ethnoepistemology. Ethnoepistemology is examined in terms of its local ontological-worldview, which mostly is spiritual in character.  It was found out that the local worldview generates a particular knowledge, with specific logic, method and vocabulary of its own. Complemented with some case-studies, the article comes up with the idea that the mistery of the world can be accessed from many points of view, resulting in different kinds of knowledge. That said, while scientific epistemology is not the only possible one, ethnopistemology can upgrade itself by learning from the work-ethos of scientific epistemology.  

Key words: episteme, worldview, logic, interdependency, holistic, experiential
II. Meşrutiyet ’ten Cumhuriyet’in İlanına Kadar İstanbul’da Kamusal Alanda Kadınlar
Authors: KAYMAZ MERT Melek , KAYMAZ GENÇAL Emine
Published: January 2023

1908 yılında II. Meşrutiyet’in ilanı ile Osmanlı İmparatorluğu’nda birçok değişim ve dönüşüm gerçekleşmiştir. Bu dönüşüm, kadınları da içine alacak şekilde yayılmış, daha önce görülmemiş birçok gelişmenin önünü açmıştır. İttihat ve Terakki Fırkasının, kadınları modernleşmenin ve Batılılaşmanın bir aracı olarak gören bakış açısı, kadınların toplumsal yaşamdaki varlığını geçmişe nazaran kolaylaştırmıştır. Bu bağlamda İstanbul’un kadınların kamusal alanda varlığı konusundaki önemi büyük olmuştur. II. Meşrutiyet döneminden Cumhuriyet’in ilanına İstanbul’da kadınlar dernekler kurmuş ve dergiler çıkarmıştır. İstanbul’da yeni açılan okullarda kız çocuklarının okuyabilmeleri, meslek sahibi olabilmeleri için yeni fırsatlar doğmuştur. Ayrıca İstanbul sınırları içerisinde kadınlar iş gücüne katılmışlar, memuriyet hayatına geçmişlerdir İmparatorluğun başkenti olan İstanbul adeta kadınların kamusal alandaki görünürlüğünün de başkenti haline gelmiştir. Bu çalışmanın amacı Osmanlı İmparatorluğu’nun son dönemlerinden Cumhuriyet’in ilk yıllarına kadar İstanbul’un kadın tarihindeki yerini ve önemini anlatmaktır. Bu bağlamda 1908-1923 yılları arasında İstanbul’da kadınların kurdukları dernekler, çıkardıkları dergiler, kadınlar adına yürütülen eğitim faaliyetleri ve iş gücüne katılımları; arşiv belgeleri ışığında incelenecektir.
Optimization of stage of gibberellin spray in Cape gooseberry (Physalis peruviana L.) for the improvement of yield and fruit quality under subtropical condition
Authors: Singh Madhvendra Bahadur , Kumar Pawan , Kundu Manoj , Samanta Dinabandhu , Sengupta Samik
Published: January 2023

The current experiment was conducted to optimize the actual time of gibberellin (GA3) spray in cape-gooseberry (Physalis peruviana L.) to improve growth, yield, and fruit quality traits. Experimental observations revealed that physiological growth (leaf relative water content, specific leaf weight) was improved significantly by three repeated applications of GA3 @ 100 ppm each at vegetative, anthesis, and again at the fruit setting stage. GA3 spray @ 25 ppm each at all three growth stages had the longest flowering period; although the harvest span was calculated maximum in three repeated GA3 sprays @ 100 ppm each. Three applications of GA3 @ 25 ppm each also increased the fruit yield at its maximum level (31.79 t ha-1 ). Three foliar spray of GA3 at any concentration increased the TSS significantly over the respective control; however, the acidity was reduced at the maximum level when GA3 was applied @ 50-100 ppm each at all three growth stages. But reducing and non-reducing sugar content was maximum under GA3 spray @ 100 ppm each during all three growth stages (8.33 and 2.70%, respectively) with statistically at par results in three applications of GA3 @ 25-75 ppm each. Hence, it can be concluded that GA3 application @ 25 ppm each at vegetative, anthesis, and again at fruit setting stage is optimum to improve the yield of better quality cape gooseberry fruit significantly.
Afghan-China Mutual Security Interests
Authors: Bazwan Jalal
Published: January 2023

The history of the Sino-Afghan relationship can be traced back to the 7th Century when Chinese monks traveled to Afghanistan through the Silk Road, to visit the Buddha statues in Bamyian, a province in Afghanistan. The continued China-Afghanistan relationship was disrupted following 9/11 and the subsequent US-NATO military presence in Afghanistan. The former played a leading role in the reconstruction of a new Afghan government and training of the Afghan forces. There was no Chinese involvement in Afghanistan during the US-NATO years. Instead, a mutual relationship was formed after the US-NATO withdrawal from Afghanistan. In a post- 2014 combat forces withdrawal of the US-NATO forces, China started playing an active role in resolving the Afghan conflict. China has security interests in Afghanistan, and as long as the security threats in Afghanistan remain unsolved, China may hesitate to strengthen its economic and investment relationship with Afghanistan. When talking about the Chinese security interests in Afghanistan, East Turkistan Islamic Movement (ETIM) is one of the grave concerns for China. In order to secure the China-Afghan relationship, the Chinese would require that the Afghan government contain ETIM and prevent their operation from Afghanistan. This is necessary so that ETIM is unable to function from Afghanistan and use the country as a safe haven for cross-bordered operations. Further, any subsequent strengthening of Afghan-China relations would require mutual interlards investment, and the success of investments is pegged on eliminating security threats. This paper discusses the Afghan-China mutual security interests and how an insecure Afghanistan is not only a threat to Chinese national security, but it will also have a grave impact on Chinese investment and the connectivity program of the region.
Assistência De Enfermagem No Pré-Natal À Primigesta Em Idade Avançada
Authors: Alves Daiane Regina Santos Apolinário
Published: January 2023

Objetiva-se abordar principais cuidados de enfermagem na atenção ao pré-natal associados aos extremos de idade materna avançada. Os dados foram coletados por meio de um estudo bibliográfico embasado em diversos autores que falam sobre o assunto. A gravidez em idade materna avançada esteve associada há vários fatores pessoais, sociais e econômicos e deve ser acompanhada para o não acarretamento de complicações. Após pesquisa, concluímos que houve uma aumento significante na vivência da gestação em idade avançada por enfermeiros.
Business management of Homeomed Sdn. Bhd. – A case study of a local SME
Authors: Syed Syed Ezanee Zulfakhri , Nadarajah Gunalan
Published: January 2023

Homeopathy is categorized under Traditional and Complimentary Medicine (TCM) and is an underrated business both by the government and the public. There is less support by the government from the perspective of acknowledgement, nationwide publication, and validation on homeopathy as an important complimentary medicine.   To escalate the issue further, homeopathy practitioners have been practicing homeopathy in a traditional manner and disconnected with the principles and concepts of business management and administration. Homeomed Sdn. Bhd. (Homeomed) is one of the homeopathy companies; operating in Bukit Beruang, Melaka; they had almost ceased the business few times due to high operational cost and the effects of Covid-19 pandemic. They were experiencing the classical business challenges for SME of having a “bulk business issues” in all aspects of business management due to incompetency or ignorance or both. The main tasks here is to identify the gaps from a business point of view and to propose a few improvement recommendations focusing on operation, marketing, sales, human resource, finance, supply chain and customer service. During the implementations of new business techniques and approaches, main performance indicators such as revenue, number of patients, inquiries and customer satisfaction were measured to reflect Homeomed’s competitiveness. The data collected are analysed and studied for further improvement initiatives. The data collected are analysed and studied for further improvement initiatives. A total of five main problem areas were identified and solutions were implemented in 5 stages with all of it deriving positive outcomes.
First-principle study of mechanical, optical and thermophysical properties of NiTiSn
Authors: Gour Atul , Yadav Suman , Rathore Rahul , Singh Sadhna
Published: January 2023

In present work we have studied half-Heusler compound NiTiSn in perspective of optical, mechanical and thermophysical properties at high temperature and high pressure using density functional theory. We have calculated various dielectric properties viz absorption coefficients, optical conductivity, optical reflectivity and electron energy loss. We have also found high refractive index n(0) ≈ 5 of NiTiSn indicating highly denser medium for low energy waves. The calculated absorption coefficient and optical conductivity are in agreement with the experimental ones for optical device. The optical investigation of the compound shows high reflectivity in the UV region of the photon energy. The elastic properties are investigated in most stable structure of NiTiSn in order to ensure its mechanical applications. Our estimated values of Poisson ratio (n = 0.2735) and pughratio (B/G = 1.87) confirm the metallic nature of NiTiSn. Various thermophysical properties viz. Debye temperature, isothermal coefficients, heat capacity, entropy and volume have been studied at high temperature and high pressures which will upgrade its thermoelectric properties study. The thermophysical properties ensures the Debye T3 law and Dulong Petit limit of NiTiSn at high temperatures and high pressures.
ANALISIS SIKAP IBU TENTANG STIMULASI TUMBUH KEMBANG BALITA STUNTING USIA 2-3 TAHUN DI SURAKARTA
Authors: Maulida Luluk Fajria , Maulina Rufidah , Sari Atriany Nilam , Novika Revi Gama Hatta , Wahidah Nurul Jannatul , Nurhidayati Siti
Published: January 2023

Tahapan perkembangan anak memang sangat menakjubkan, karena pada setiap tahapan perkembangan anak tidak hanya tumbuh secara fisik, tetapi juga secara mental hingga kecerdasannya. Salah satu syarat menuju perkembangan yang optimal adalah sikap orang tua atau pengasuh yang positif. Tujuan penelitian ini adalah mengetahui sikap ibu tentang stimulasi tumbuh kembang balita stunting usia 2-3 tahun di Surakarta. Metode penelitian menggunakan deskriptif analitik dengan pendekatan cross sectional. Penelitian ini dilaksanakan bulan April 2022 di Kelurahan Pasar Kliwon dengan teknik total sampling. Jumlah responden sebanyak 30 orang. Analisis data menggunakan analisis univariat. Hasil penelitian ini diperoleh ibu yang bersikap positif sebanyak 46,7% dan bersikap negatif sebanyak 53,5%. Kesimpulan penelitian ini adalah sebagian besar ibu bersikap negatif terhadap stimulasi tumbuh kembang balita stunting usia 2-3 tahun. Diperlukan pelatihan maupun pendampingan pada keluarga untuk mengoptimalkan stimulasi tumbuh kembang balita.
Literature Review: Efektifitas Metode Moist Wound Healing pada Ulkus Diabetik
Authors: Lestari Desi , Puspitasari Indah , Sunirah Sunirah
Published: January 2023

One of the complications of diabetes mellitus is the presence of ulcer wounds which cause 50% to 75% of amputation. This literature review aims to determine the effectiveness of the Moist Wound Healing method in diabetic wounds. The design of this scientific paper is a literature review search using an electronic database, namely google scholar, semantic scholar, and pubmed. The keywords used in the search were: diabetes mellitus AND moist AND diabetic ulcer. Based on a literature review of 4 articles, significant results were obtained in wound healing, namely 2-3 times faster healing. it can be concluded that the moist wound healing method can affect the healing process of diabetic ulcers and has effectiveness for wound healing.
Substitusi Mie Sumber Zat Gizi Mikro Bahan Pangan Lokal Lahan Gambut terhadap Daya Terima Balita Underweight Umur 24-59 Bulan
Authors: Dahliansyah Dahliansyah , Hariyadi Didik , Desi Desi
Published: January 2023

Nutritional problems are still a serious impact on the quality of human resources in Indonesia, especially the problem of double nutrition in children under five. Underweight is one of the serious nutritional problems that need to be addressed in addition to stunting. The handling of undernourished children under five is done by providing additional food (PMT). One of the local ingredients that can be made is dry noodles, which are high in micronutrients. Making noodles can be modified from local ingredients, including yellow sweet potato where sweet potato (Ipomoea batatas L) is a type of tuber that has many advantages. Noodles can be enriched with nutrients by adding micronutrients sourced from local peatlands, namely snakehead fish and red ferns. Snakehead fish has a protein content of 25.2%, and contains albumin 62.24 g/kg (6.22%). While the red fern contains the minerals Calcium and Iron 291.32 mg per 100 mg of material, allowing it to prevent anemia. This study aims to determine the Substitution of Noodles Source of Micronutrients Local Food Ingredients on Peat Land on Nutritional Quality and Acceptability of Underweight Toddlers Age 24-59 Months in the District of Rasau Jaya. The design of this research is pure experimental (true experiment. The number of panelists is 30 people. Statistical test using Friedman statistical test to analyze the differences in substitution of yellow sweet potato, snakehead fish and red fern on organoleptic quality (color, taste, aroma, and texture). Test results acceptability based on the average amount according to color, aroma, taste, and texture on dry noodles as a whole obtained the highest results in treatment 1, namely F1 with a total of 451. The best value was obtained in treatment P1, where the best treatment was the treatment with the highest NP value, namely P1 of 0.78 with the following characteristics: color 3.83 (somewhat like), aroma 3.97 (somewhat like), taste 3.53 (somewhat like), texture 3.53 (somewhat like), Like) Friedman test results showed that there was no effect of the addition of yellow sweet potato, snakehead fish extraction and red fern extraction on d I accept the color, taste, aroma and texture of dry noodles.
Hubungan Pengetahuan Manajemen Laktasi dengan Pemberian ASI Eksklusif pada Ibu Menyusui
Authors: Frisilia Melisa , Handriani Egha
Published: January 2023

Lactation management is all efforts to help mothers succeed in breastfeeding their babies. Exclusive breastfeeding is giving only breast milk to the baby and not giving the baby any other food or drink. The implementation of midwifery activities as the spearhead of the implementation of the MCH program shows that, in general, the quality of the implementation of midwifery activities, including Antenatal Care services, is still low. This study aims to know the relationship between lactation management with exclusive breastfeeding in nursing mothers. The design method in this study is correlational research. The method used in this study uses secondary data derived from several research journals, namely, Hilarius Holan Woja et al. (2018), Yovan Hendrik, Elise Putri (2016), Herry, Evi Nurafiah (2020). Results of the analysis of the 3 (three) study obtained a significant value = 0.006 (p-value ≤ 0.05. There is a relationship between knowledge of lactation management and exclusive breastfeeding for breastfeeding mothers.
Karakterisasi Nanokapsul Ekstrak Daun Serunai (Chromolaena odorata L.) dengan Variasi Kitosan-Alginat Menggunakan Metode Emulsi-Difusi
Authors: Hatmayana Roosma , Noval Noval , Mahdiyah Dede , Ramadhani Rizki Adhie , Auliyani Nurul
Published: January 2023

Serunai (Chromolaena odorata L.) is a plant that has been widely used in medicine, one of which is as an antidiabetic. But treatment using plant extracts has drawbacks to the solubility of the active substance and its bioavailability in the body. Nanocapsules are one of the systems in particle technology that can solve this problem by utilizing a polymer that will encapsulate the active substance and release it slowly at the intended target. To achieve this, the manufacture of nanocapsules must meet several characteristic requirements such as particle size, potential zeta, absorption efficiency, and emulsion stability. This study was conducted to identify the nanocapsules characteristics of Serunai leaf extract (Chromolaena odorata L.) with chitosan-alginate variations and identify the influence of chitosan-alginate variations on the characteristics of nanocapsules. This study is a laboratory experimental study with a one-group posttest-only design. The manufacture of Serunai leaf extract nanocapsules using the emulsion-diffusion method, which is then characterized including particle size determination, potential zeta determination, absorption efficiency test (%EE), and emulsion stability test. The results obtained from the determination of the particle size of Formula I 196.4 nm, Formula II 264.2 nm, and Formula III 207.4 nm, potential zeta Formula I -36.1 mV, Formula II -40.1 mV, and Formula III -36.5 mV, the formula I %EE values 99.7%, Formula II 99.8%, and Formula III 99.7%, as well as all formulas indicating the emulsion type m/a. Three formulas have met the requirements of nanocapsules characteristics. The formula is best obtained in Formula II with a chitosan concentration of 0.3% and alginate of 0.6%, so chitosan-alginate variations influence the characteristic results.
Formulasi Sediaan Gel Hand Sanitizer dengan Kombinasi Ekstrak Lidah Buaya (Aloe vera L.) dan Ekstrak Daun Mengkudu (Morinda citrifolia L.)
Authors: Handayani Rezqi , Qamariah Nurul , Bestary Yelly
Published: January 2023

Gel Hand Sanitizer is a hand sanitizer useful for cleaning or eliminating germs on hands. Aloe Vera (Aloe vera L.) contains active substances such as saponins that function as antiseptics. Substances contained in noni leaves (Morinda citrifolia L.) that act as antibacterials are anthraquinones. This study aims to determine whether the combination of Aloe vera extract (Aloe vera L.) and Noni leaf extract (Morinda citrifolia L.) can be formulated as a hand sanitizer gel. This study used experimental research methods; in this study, modifications were made to the formulas, namely F0, F1, F2, and F3, with modifications in the amount of carbopol and different glycerin. The tests on the four formulas, including organoleptic and pH tests, meet the requirements for testing preparations. At the same time, the homogeneity test showed that only the gel base was homogeneous, while formulas 1, 2, and 3 were not homogeneous. This research concludes that Aloe Vera (Aloe vera L.) extract and Noni leaf extract (Morinda citrifolia L.) cannot be formulated into hand sanitizer gel preparations because the texture of the preparations is not homogeneous and still leaves a color when applied on the hands.
Selection of common bean parents and segregating populations targeting fusarium wilt resistance and grain yield
Authors: Silva Adriel Carlos , Salvador Felipe Vicentino , Souza Michael Henriques , Marçal Tiago Souza , Dias Fabiola Santos , Mello Vinicius Lopes , Carneiro Pedro Crescêncio Souza , Carneiro José Eustáquio Souza
Published: January 2023

The present work aimed to select populations for the breeding of common bean targeting fusarium wilt resistance and grain yield. Twelve carioca bean lines, which mainly differ in fusarium wilt resistance and grain yield, were crossed in a 6x6 partial diallel scheme. The parents and their 36 F1’s hybrids were evaluated for fusarium wilt severity caused by FOP isolate UFV 01 (FWS), and grain yield (YIELD). 34 F4’s populations, 12 parents and three other lines were also evaluated for grain yield per plant. The data of F1's parents and hybrids were submitted to diallel analysis. Using the grain yield data per plant, the potential of the 34 F4’s populations was predicted by the Jinks and Pooni method (1976). In the diallel analysis, BRSMG Talismã, CVIII 8511, BRS Pérola, VC 25 and VC 13 stood out in terms of the frequency of favorable alleles for FWS. Except for BRSMG Uai and IAC Formoso, these lines presented the most dominant genes associated in Fusarium wilt resistance. For YIELD, there was a predominance of dominant genes determining higher yield. The 20 F4’s populations with the highest potential included the best 12 of the 20 populations, based on diallel analysis for YIELD. Thus, the 12 populations received the addition of four that were highlighted only by the methodology of Jinks and Pooni (1976), and four based on diallel analysis, which totaled 20 populations. The use of information from more advanced inbreeding generations in complementarity with those of diallel is a promising strategy.
Specjalne miejsce w sercu
Authors: Pilecka Hanna , Robačevskis Elijus
Published: January 2023

Wybitnie utalentowany jedenastolatek opowiada o tym, jak inspirują go rodzice, Natalija Robačevskiene i Emilis Robačevskis, oraz o pewnej niezwykłej podróży.
Czas dzieci
Authors: Pilecka Maria
Published: January 2023

Karaimka z Gdańska, która do Trok przywiozła swoje wnuki zamieszkałe w Oksfordzie, opowiada o sierpniowym spotkaniu licznej grupy „buńdziuków”.
Reuse of water and sludge in agriculture: new technologies for the treatment
Authors: Fernandes Samuel Cassiano , Amaral Ana Maria Santana do , Zanetti Willian Aparecido Leoti , Putti Fernando Ferrari , Góes Bruno César
Published: January 2023

The treatment and reuse of water in Brazil is one of the most discussed issues in the agricultural field. In recent years, the scarcity of water changes in the rainfall regime has impacted production. The management of water resources aims to make better use of one of the means that most uses water, agriculture. Reuse and treatment are essential through innovative technologies that corroborate better water efficiency to extract the maximum water capacity and avoid waste. In an increasingly sustainable scenario, which seeks cleaner environments, with little or no emission of pollutants and losses of water resources, the reuse and treatment or possible disposal in a correct way is always an object of study to achieve the effect in use. of water, seeking better production in crops and reducing environmental impacts. This work aims to analyze the historical evolution of technologies used to treat wastewater and sewage sludge. We can see that the theme has grown in recent years, and several technologies are emerging to improve water treatment more efficiently and effectively. Thus, we conclude that the reuse of wastewater and sewage sludge has a large field of study and application in agriculture.
Características sociodemográficas, sintomas persistentes e qualidade de vida de pacientes após hospitalização pela COVID-19
Authors: Nicolau Natiéli Rauber , Lotici Gisele , Perondi Alessandro Rodrigues , Bortoloti Durcelina Schiavoni , Zonta Franciele do Nascimento Santos
Published: January 2023

A COVID-19 é uma doença causada pelo vírus SARS-CoV-2 com manifestações leves a graves, como também levar à morte. Estudos têm demonstrado que pacientes que foram hospitalizados pela doença apresentam sintomas persistentes mesmo após longo período da alta, com impacto na qualidade de vida. Objetivo: Avaliar as características sociodemográficas, sintomas persistentes e a qualidade de vida de pacientes após hospitalização pela COVID-19 de um município do sudoeste do Paraná. Metodologia: Trata-se de um estudo descritivo-exploratório, de campo, transversal, com abordagem quantitativa, realizado com pacientes que foram hospitalizados devido a COVID-19, após a alta hospitalar em um município do sudoeste do Paraná. Realizou-se um cálculo amostral, assim a pesquisa constituiu-se por cinquenta (50) pacientes. Foram utilizados um questionário semiestruturado para avaliar as variáveis demográficas e dados clínicos do internamento além do instrumento WHOQOL-BREF; a escala de dispneia do Medical Research Council e a Escala Visual Analógica de dor. Resultados: Observou-se que 66% dos pacientes avaliados são do sexo masculino, sendo a maioria jovens, com ensino fundamental completo, casados, portadores de doenças crônicas, destacando-se a hipertensão arterial e a obesidade. Verificou-se que grande parte apresenta sintomas persistentes, predominando memória prejudicada e artralgia, mesmo após longo tempo de alta hospitalar, gerando impacto negativo na qualidade de vida. Conclusão: Pacientes que foram hospitalizados por COVID-19, especialmente homens, jovens, com comorbidades apresentam sintomas persistentes, após longo período de alta hospitalar, com impacto negativo na qualidade de vida, realçando assim a necessidade de acompanhamento a longo prazo a tais pacientes.
Divulgando junto às mídias sociais uma tecnologia educacional aplicável à mucosite oral em crianças e adolescentes: um relato de experiência
Authors: Mincov Bruna Menezes , Novakovski Thammy , Paula Káryta Jordana Santos de , Castro Gisele Cordeiro , Freire Márcia Helena de Souza
Published: January 2023

Objetivou-se relatar o registro e divulgação de uma Tecnologia Educacional em órgãos e instâncias competentes, bem como, em plataformas sociais, por meio do registro na ANCINE e no REA/PEA UFPR, divulgação em redes sociais como Instagram, Facebook, Youtube, WhatsApp, e TikTok, e construção de um cartaz. O vídeo foi registrado na plataforma do REA/PEA UFPR, e na ANCINE, como obra não publicitária. Também foi divulgado no Youtube, Instagram, Facebook do grupo NEPES UFPR e em outras redes sociais como WhatsApp, e TikTok (@mucosite_saude). O cartaz, com o título do vídeo, seu objetivo e o QRcode, foi colocado nos corredores da faculdade UFPR e no Hospital das Clínicas, mais especificamente nos quartos STMO. As mídias sociais representam uma maneira fácil, dinâmica e atraente de difusão do conhecimento, principalmente entre crianças e adolescentes, que estão em contato recorrente com as plataformas sociais. A aplicação da presente produção possibilitará o desenvolvimento de outros estudos e de novas propostas de tecnologias aplicáveis em oncologia pediátrica e TCTH; assim como, estimulará a divulgação das tecnologias produzidas no âmbito da enfermagem e saúde.
Tumor Glômico Gástrico: Um caso raro de neoplasia benigna
Authors: Freitas Marielle , Souza Júnior Joilson Francisco de , Lamboglia Gustavo Rivelli , Caldas Gustavo Costa , Medeiros Luiz Eduardo Dantas Cerqueira , Alves Júnior Antonio
Published: January 2023

O tumor glômico gástrico é uma lesão neoplásica originada no canal neuromioarterial. A habitual localização do corpo glômico permite que a incidência deste tipo de tumor se dê, na maioria dos casos, em tecidos moles periféricos e extremidades. No entanto, o tumor glômico pode se desenvolver, de forma extremamente rara, em regiões viscerais, como o trato gastrointestinal. Neste sentido, são raros também os relatos na literatura científica sobre este tipo de neoplasia, o que dificulta ainda mais a identificação antes de interferências cirúrgicas. Algumas estratégias têm sido utilizadas nas últimas décadas para tornar o diagnóstico mais eficiente, dentre estas, a tomografia computadorizada (TC) tem se destacado. Neste estudo, foi realizada uma revisão sistemática da literatura científica no sentido de embasar teoricamente um estudo de caso. Para o desenvolvimento deste estudo, relata-se um caso de um paciente do sexo masculino, 54 anos de idade, com histórico de hematoquezia há aproximadamente 2 meses. O paciente foi submetido a uma série de avaliações para a detecção do tipo de tumor gástrico. Dentre estes exames que foram utilizados na composição do diagnóstico, a TC foi a responsável pela indubitável detecção do tumor glômico gástrico, uma vez que o tumor apareceu bem definido em contraste. Isto permitiu o encaminhamento do paciente ao procedimento cirúrgico. O presente estudo tem como principal objetivo auxiliar no diagnóstico diferencial em casos de hematoquezia, bem como na diferenciação de tumores glômicos gástricos de outros tumores estromais gastrointestinais.
THE BENEFITS AND LOSSES OF ONLINE LEARNING IN THIRD-AGE UNIVERSITIES DURING THE COVID PANDEMIC
Authors: KAMANOVÁ LENKA , PEVNÁ KATEŘINA
Published: January 2023

Due to the pandemic situation, the online form of education has become widespread in all its spheres. The education of seniors, which is provided, among others, at universities of the third age, has been no exception. Prior to the global pandemic, universities of the third age mainly provided full-time education. However, the new situation has brought new challenges. Third Age Universities have either decided to provide online education or have temporarily ceased their activities. In this paper, we focus on online education during the pandemic at a particular third age university. Based on the results of a questionnaire survey, we present the experiences of seniors with online learning, specifically, identifying the advantages of online education for seniors and the disadvantages of this form of education for this target group. To achieve these objectives, a quantitative research survey was conducted among seniors who participated in online learning at the University of the Third Age in question.
Evaluasi Metode Perbaikan Tanah Lunak dengan Preloading Kombinasi PVD-PHD pada Proyek Pembangunan Jalan Tol Semarang-Demak Paket II
Authors: Aini Irvita Asri , Maulana Eggy Ihza , Santoso Hinawan Teguh
Published: January 2023

Soil condition in the construction of the Semarang-Demak II Toll Road Project on the northern coast of Java Island is dominated by soft soil. Soft soil has the potential to cause problems such as relatively low permeability, poor bearing capacity, and large long-term settlements that will cause damage to the construction above it in the future. Therefore, it is necessary to improve the soft soil capacity, one of which is the Preloading and PVD-PHD combination method. This study aims to evaluate the value of settlement and consolidation time of embankment on soft soil between design and construction. The research method is carried out by field investigation/survey methods to obtain data on the settlement magnitude and consolidation time of embankment, and find possible causes of differences. The study found that there were differences in the value of the settlement and the consolidation time between the design and actual conditions in the field. The final settlement when the degree of consolidation reached 90% was observed to be almost the same between the design and actual condition, where the difference was 0.0063 meters or 2.81%. However, a significant difference was found between the time of consolidation for design and construction, which was 28 days (14.70%) faster than the estimation time. Factors that influence the difference in consolidation time, include: the volume weight of the preloading embankment in the field is 1.65 kN/m3 (9.70%) higher than the plan, the embankment elevation in the field is 0.237 meters (3.36%) higher than the design, and the use of drainage well to dissipate water trapped in the “trap-zone” in the middle of the embankment.
Stroke and Systemic Lupus Erythematosus: A Review
Authors: Cavallaro Marco , Barbaro Ugo , Caragliano Antonio , Longo Marcello , Giuseppe Cicero Giuseppe Cicero , Granata Francesca , Racchiusa Sergio
Published: January 2023

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that involves collagen tissue throughout the body. Several previous studies have shown that the risk of ischaemic and haemorrhagic stroke is significantly higher in SLE when compared to the general population, particularly in young individuals, representing one of the principal causes of death in these patients. Though the precise pathophysiology behind this increased risk is still poorly understood, several mechanisms are suggested to play a role. The high burden of cerebral small vessel disease features noted on brain neuroimaging studies, as well as the accelerated process of atherosclerosis identified in these patients, are likely to be responsible for at least some of the ischaemic strokes occurring in the SLE population. Repeated episodes of arterial and venous thrombosis secondary to antiphospholipid syndrome are likewise important. Less is known regarding the exact pathophysiological relationship between SLE and the high incidence of haemorrhagic stroke, though thrombocytopenia and a greater susceptibility to form typical and atypical brain aneurysms, which may then rupture, are thought to be the main mechanisms responsible for the occurrence of intracerebral and subarachnoid haemorrhage, respectively. Both inflammatory and noninflammatory events, all involving the immune system, are responsible for several pathological changes affecting cerebral vessels of every calibre in SLE, as confirmed by histopathology. In this context, endothelial activation and dysfunction play a critical role. This review will briefly analyse the most important factors responsible for the higher ischaemic and haemorrhagic stroke risk in the SLE population, with a particular focus on brain vascular changes.
Anti-TNF in Rheumatic Diseases: Inventory and Outlook
Authors: Bella Laura , Ali Rugina
Published: January 2023

With an increasing number of biosimilars receiving regulatory approval, the treatment landscape for rheumatic diseases is evolving. Healthcare professionals (HCP) are being presented with an expanding armamentarium of treatment options that can increase patient access to effective biologic therapies and offer an opportunity for healthcare systems to benefit from significant cost savings. In recent years, accumulation of clinical and real-world data with biosimilars has helped physicians gain confidence in the use of biosimilars in daily clinical practice. However, further information regarding best practices of how to effectively introduce biosimilar therapies into a busy clinic is still required. This symposium aimed to uncover various aspects of preparing for a switch, providing suggestions for clinical parameters and imaging tools to aid identification of patients who will respond optimally to biologic treatment. Additionally, HCP–patient communication was analysed from a psychosocial perspective, covering shared decision-making and how to appropriately address common concerns raised by patients. Finally, during this interactive session, country-specific perspectives on best practices for successful switching and the use of remote monitoring tools for patient follow-up were also discussed.
A Review of Adalimumab Biosimilars for the Treatment of Immune-Mediated Rheumatic Conditions
Authors: Valido Ana , Araújo Filipe C. , Eurico Fonseca João , Gonçalves João
Published: January 2023

Adalimumab is a recombinant fully human monoclonal antibody targeting soluble and transmembrane TNF alpha. It is approved for the treatment of immune-mediated rheumatic, gastroenterological, dermatological, and ophthalmological conditions and this therapeutic versatility has made it the top-selling drug worldwide since 2012. Not surprisingly, following the patent expiration of the originator drug, biopharmaceutical companies invested in the development of biosimilar versions of adalimumab and six have already received marketing authorisation: ABP 501, GP2017, and BI 695501 in Europe and in the USA (though the manufacturer of the latter requested authorisation withdrawal in Europe), and SB5, FKB327, and MSB11022 in Europe. This manuscript reviews published data on approved adalimumab biosimilars, including analytical and biofunctional results from preclinical assessments; pharmacokinetics after administration in healthy subjects (Phase I trials); and efficacy, safety, and immunogenicity from pivotal (Phase III) clinical trials. Data on switching from reference adalimumab to biosimilars, and predicted cost-savings from available budget impact models, will also be addressed.
Ageing and Childhood: Dementia in Chinese-Language Picturebooks
Authors: Chen Shih-Wen Sue
Published: January 2023

Although the number of people with dementia has been increasing rapidly in the Chinese-speaking world, there are relatively few Chinese children’s books published on the topic. This article analyses two Chinese-language picturebooks that approach the representation of dementia in contrasting ways. Azihaimo xiansheng [ Mr Alzheimer] (2017) by Chen Yihui and Xue Huiying downplays the threat of the disease by anthropomorphising it as a friendly man while Zhanxin de yitian [ A New Day] (2017) by Guo Yu and Lianggen creates a surrealist nightmarish vision of what a person with dementia feels like daily. The article argues that, although the former book romanticises dementia while the latter presents it as a terrifying condition, both texts infantilise the person with dementia, thus reinforcing ageist tropes.
Russian Translations of Parodies of Didactic Verses in Alice's Adventures in Wonderland: What Got Lost in the Rabbit Hole?
Authors: Vid Natalia Kaloh , Žagar-Šoštarić Petra
Published: January 2023

This study focuses on Carroll's parodies of didactic Victorian poems in twelve Russian translations of Alice's Adventures in Wonderland released over the twentieth century (1924–2000). All parodied verses were well known to Carroll's contemporary readers and this element of recognition was further reinforced by the fact that such poems were learnt by heart and recited. Much of the humour in these parodies is based on a mockery of social protocol and deconstructing of moral and didactic principles of the Victorian era, a distant and barely known epoch for the target audience of Russian children or adults. The primary goal of the analysis is to examine solutions offered by Russian translators to achieve the recognisability and clash of meanings commonly found in parodies. The domesticating method used by the translators is clearly one that enables easier recognisability of a parody, while foreignising helps the translator to faithfully convey the message of the original parody and to keep ironic and nonsensical elements.
Community and Individuality in Chinese and American Picturebooks: A Contrastive Study of Constructs of Childhood
Authors: Jiang Jianli , Xu Derong
Published: January 2023

This article explores how influential picturebooks in China and the United States reveal differences in the constructs of childhood and education between Asia and the West through an analysis of the cultural basis of their production and their common underlying script (story or narrative patterns expressing how a sequence of events or actions is expected to unfold). It finds that although these works bear many similarities in their scripts, they are underpinned by very different representations of community and individuality. The Chinese picturebooks in question are about testing the comparative worth of (usually three) young people by setting them a task, and they thus reinforce the schema that individual achievements are a natural result of community. In contrast, the American picturebooks under investigation are based on a script that involves having faith in and putting one’s talent to use, and thus enhance a schema that community is a natural result of personal achievements. Although societies continue to change, such scripts and schemas have remained functional and had their transformative potential until today.
Bronchoalveolar lavage in pediatric oncohematology
Authors: Krylovetskaya M. A. , Gusarova O. A. , Savosin R. S. , Valiev T. T. , Kuvshinov Y. P. , Grigorievskaya Z. V. , Malikhova O. A. , Tumanyan A. O.
Published: January 2023

Relevance. Pulmonary lesions of infectious etiology in oncohematological children are common and, in some cases, may be accompanied by a lethal outcome. When pulmonary tissue lesions on the background of hematopoiesis aplasia in the post-chemotherapy period is shown bronchoscopy to determine the genesis of the identified changes.

Aim. To determine the diagnostic value of bronchoscopy with BAL in children with oncohematological diseases.

Materials and methods. 25 bronchoscopies with BAL were performed on the basis of the endoscopic department of the Research Institute of Pediatric Oncology and Hematology.

Results. According to the results of the study in 72% of cases a microbiologic agent was detected. The most frequent pathogens obtained by the results of cultures were Haemophilus parainfluenzae, Streptococcus oralis, Neisseria macacae, Streptococcus peroris and Pseudomonas aeruginosa.

Conclusions. Bronchoscopy with BAL in children with blood system tumors is a highly informative method of pathogen detection and determination of the etiological cause of infiltrative-inflammatory changes in the lungs.
Organic Carbon Burial in Constructed Ponds in Southern Sweden
Authors: Ljung Karl , Lin Simon
Published: January 2023

Small ponds constructed for nutrient retention, biodiversity conservation or recreation also store large amounts of carbon. The potential role of small ponds for carbon storage and greenhouse gas emissions have been highlighted both in the scientific literature and in management plans. The role of small ponds in the global carbon budget is likely significant, but the potential has not been fully explored. Here we present measurements of yearly sedimentary carbon accumulation and carbon stocks in six small, constructed and restored ponds in southern Sweden. The ponds were constructed or restored during the last 20 years primarily for nutrient retention. The sediment cores span the time from the construction of the ponds until today. The ponds had high carbon accumulation, with mean total carbon stocks in the top 6 cm of sediment of 836 g C m
−2
and a yearly mean C accumulation rate of 152 g C m
−2
 yr
−1
. The total amount of restored wetlands within the restoration program studied here has a total area of 480 ha, and upscaling the carbon stocks to the whole area of restored ponds and wetlands gave a total carbon stock of 4.013 × 10
6
 kg C in the top 6 cm of the sediments. If considering the potential increase of CO
2
and CH
4
from the ponds it is likely that the constructed ponds studied here are net carbon sources. We compared our results with published measurements of CO
2
and CH
4
emissions from small ponds in Sweden. This shows that the CO
2
equivalent emissions could be between 1.8 and 37.5 times higher than the sedimentary carbon accumulation. Our data indicate that small constructed ponds are potential net carbon sources. Therefore, we suggest that using small, constructed, or restored ponds as carbon mitigation strategy must be done with caution, and the potential for increased methane emissions must be considered.
Mesenchymal stem cells express epidermal markers in an in vitro reconstructed human skin model
Authors: Dos Santos Jeniffer Farias , Freitas-Marchi Bruna Letícia , Reigado Gustavo Roncoli , de Assis Silvia Romano , Maria Engler Silvya Stuchi , Chambergo Alcalde Felipe Santiago , Nunes Viviane Abreu
Published: January 2023

Introduction: In skin traumas, such as burns, epidermal homeostasis is affected, often requiring clinical approaches. Different therapeutic strategies can be used including transplantation, besides the use of synthetic or natural materials with allogeneic cells. In this context, tissue engineering is an essential tool for skin regeneration, and using mesenchymal stem cells (MSC) from the umbilical cord appears to be a promising strategy in regenerative medicine due to its renewal and differentiation potential and hypo immunogenicity. We evaluated the transdifferentiation of MSC from umbilical cord into keratinocytes in three-dimensional (3D) in vitro skin models, using dermal equivalents composed by type I collagen with dermal fibroblasts and a commercial porcine skin decellularized matrix, both cultured at air-liquid interface (ALI).

Methods: The expression of epidermal proteins cytokeratins (CK) 5, 14 and 10, involucrin and filaggrin was investigated by real-time PCR and immunofluorescence, in addition to the activity of epidermal kallikreins (KLK) on the hydrolysis of fluorogenic substrates.

Results and discussion: The cultivation of MSCs with differentiation medium on these dermal supports resulted in organotypic cultures characterized by the expression of the epidermal markers CK5, CK14, CK10 and involucrin, mainly on the 7th day of culture, and filaggrin at 10th day in ALI. Also, there was a 3-fold increase in the KLK activity in the epidermal equivalents composed by MSC induced to differentiate into keratinocytes compared to the control (MSC cultivated in the proliferation medium). Specifically, the use of collagen and fibroblasts resulted in a more organized MSC-based organotypic culture in comparison to the decellularized matrix. Despite the non-typical epithelium structure formed by MSC onto dermal equivalents, the expression of important epidermal markers in addition to the paracrine effects of these cells in skin may indicate its potential use to produce skin-based substitutes.