bluuebunny/crossref_metadata_2025 huggingface dataset:
Prácticas cinéfilas en la escuela media argentina: mirar, hablar y transmitir el discurso del cine
Authors: Benasayag Ariel
Published: April 2021

En el artículo se pretende contribuir a la reflexión sobre los vínculos entre escuela y cine. Se parte de la hipótesis de que los modos de incorporación pedagógica del cine de ficción en la escuela media argentina contemporánea están relacionados con las prácticas de los docentes como espectadores. Con este horizonte interpretativo, se revisan definiciones y caracterizaciones sobre los cinéfilos y se introduce el concepto de cinefilia, entendida como un modo de mirar y mostrar películas, de reflexionar y hablar sobre ellas y de transmitir el discurso del cine. El estudio de casos es la estrategia metodológica. Los testimonios se obtuvieron en entrevistas realizadas a dos docentes cinéfilos. En el trabajo se describen saberes y se analizan prácticas pedagógicas en las que parecen desplegarse las relaciones entre cultura cinematográfica y cultura escolar. Finalmente, teniendo en cuenta la discusión sobre el potencial de la experiencia artística en tanto alteridad de la forma escolar, se piensan los casos estudiados como posibles, aunque inciertos, encuentros con el cine —y con la cinefilia—.
Dinámicas de integración curricular escolar: interdisciplinariedad en la producción de conocimiento
Authors: Peñuela Diana
Published: April 2021

Son evidentes los cambios en las dinámicas de integración curricular en la escuela contemporánea, no solo porque se exijan modificaciones en los modos de producción de conocimiento a nivel social (Gibbons et al., 1997), o porque se nos exija adentrarnos en cuestionamientos a la disciplinariedad, sino porque, además, son transformaciones que ya se están movilizando como ejes de la política educativa tanto a escala nacional como distrital, por lo menos desde hace una década. Estas dinámicas definitivamente proponen, por lo menos, un cuestionamiento al tipo de conocimiento que se produce en nuestras escuelas. Es interesante que la política educativa posibilite este tipo de acercamientos, al menos en teoría. En este contexto, el presente artículo pretende: (a) mostrar las discusiones ya existentes en torno a la configuración contemporánea del conocimiento escolar desde los procesos de integración; (b) analizar los debates alrededor de la entrada de la interdisciplinariedad en dichos procesos; (c) sugerir la posibilidad de pensar los modelos de integración curricular como movilizadores de las formas de producción de conocimiento en la escuela: y (d) realizar un análisis reflexivo de los modelos de integración curricular a escala nacional y distrital.
Belief Change without Compactness
Authors: S Ribeiro Jandson
Published: April 2021

Dealing with dynamics is a vital problem in Artificial Intelligence (AI). An intelligent system should be able to perceive and interact with its environment to perform its tasks satisfactorily. To do so, it must sense external actions that might interfere with its tasks, demanding the agent to self-adapt to the environment dynamics. In AI, the field that studies how a rational agent should change its knowledge in order to respond to a new piece of information is known as Belief Change. It assumes that an agent’s knowledge is specified in an underlying logic that satisfies some properties including compactness: if an information is entailed by a set X of formulae, then this information should also be entailed by a finite subset of X. Several logics with applications in AI, however, do not respect this property. This is the case of many temporal logics such as LTL and CTL. Extending Belief Change to these logics would provide ways to devise self-adaptive intelligent systems that could respond to change in real time. This is a big challenge in AI areas such as planning, and reasoning with sensing actions. Extending belief change beyond the classical spectrum has been shown to be a tough challenge, and existing approaches usually put some constraints upon the system, which are either too restrictive or dispense some of the so desired rational behaviour an intelligent system should present. This is a summary of the thesis “Belief Change without Compactness” by Jandson S Ribeiro. The thesis extends Belief Change to accommodate non-compact logics, keeping the rationality criteria and without imposing extra constraints. We provide complete new semantic perspectives for Belief Change by extending to non-compact logics its three main pillars: the AGM paradigm, the KM paradigm and Non-monotonic Reasoning.
Invariance and Same-Equivariance Measures for Convolutional Neural Networks
Authors: Quiroga Facundo Manuel
Published: April 2021

Neural networks are currently the state-of-the-art for many tasks.Invariance and same-equivariance are two fundamental properties to characterize how a model reacts to transformation: equivariance is the generalization of both. Equivariance to transformations of the inputs can be necessary properties of the network for certain tasks. Data augmentation and specially designed layers provide a way for these properties to be learned by networks. However, the mechanisms by which networks encode them is not well understood.We propose several transformational measures to quantify the invariance and same-equivariance of individual activations of a network. Analysis of these results can yield insights into the encoding and distribution of invariance in all layers of a network. The measures are simple to understand and efficient to run, and have been implemented in an open-source library. We perform experiments to validate the measures and understand their properties, showing their stability and effectiveness. Afterwards, we use the measures to characterize common network architectures in terms of these properties, using affine transformations. Our results show, for example, that the distribution of invariance across the layers of a network has well a defined structure that is dependent only on the network design and not on the training process.
Análisis de factores de promoción que incidieron en la evolución de las exportaciones de Pisco hacia Estados Unidos 2015-2019
Authors:   , Cuya Selis Kelly Gissel , Rodríguez Paz Ariana Alexandra
Published: April 2021

El pisco peruano, es hoy en día unos de los principales productos bandera del país, el mismo que presenta factores de promoción que generan incidencia en los volúmenes de exportaciones hacia el principal mercado de destino de este sector que resulta ser los Estados Unidos en los últimos años. En este sentido, podemos señalar que la tesis en mención se focaliza en analizar aquellos factores promocionales referidos a los reconocimientos, eventos y acciones de posicionamiento que explican el comportamiento de las exportaciones del pisco peruano en los años 2015 al 2019 hacia el mercado norteamericano. Para ello, se ha realizado un análisis de las variables involucradas en base a sus antecedentes y bases teóricas. Asimismo, en lo referente a la validación de las hipótesis planteadas en el estudio, ésta se hizo bajo un enfoque mixto, vale decir bajo la combinación de los enfoques cualitativo y cuantitativo, siendo el caso que para el primer enfoque se utilizó una relación de causalidad al interrelacionar las variables dependiente e independiente y para el segundo enfoque se buscó el develamiento de las causas en términos de casuísticas, para ello se elaboraron instrumentos de entrevistas y encuestas que nos permitieron demostrar y alcanzar las hipótesis y los objetivos planteados respectivamente en la presente investigación.
Propuesta de implementación de un procedimiento estandarizado para mejorar la gestión de importaciones en Syrsa SAC.
Authors:   , Lagos Huamán César Deyvis , Mora Valenzuela Juan Manuel
Published: April 2021

La propuesta principal del estudio parte por “sugerir la implementación de un procedimiento estandarizado para mejorar la gestión de importaciones en Syrsa SAC”, estudio que tiene como principal objetivo analizar como un procedimiento estandarizado mejorará la gestión de importaciones en SYRSA SAC. En el aspecto metodológico el alcance es explicativo ya que estuvo dirigido a responder por las causas de los eventos y fenómenos físicos o sociales.
Las prácticas de gestión financiera y la rentabilidad de los fabricantes Mypes de calzado de Comas 2020
Authors:   , Morán Venero Evelyn Jazmín , Poémape Mayhua Milagros del Pilar
Published: April 2021

La presente investigación establece estudiar “Las prácticas de gestión financiera y la rentabilidad de los fabricantes Mypes de calzado de Comas 2020”; los datos estadísticos proporcionados por Sunat (2019) indican que Comas es el distrito que representa la mayor cantidad de empresas dedicadas a esta actividad económica. Según los autores Fernández; Naquiche y Rojas (2018) señalan que la gestión financiera es parte fundamental para una empresa, puesto que incide en la rentabilidad del negocio; sin embargo, la inadecuada gestión de esta genera descontrol sobre los recursos financieros empleados por las empresas, lo que conlleva a presentar dificultades como la falta de liquidez, no poder solventar los gastos, como también problemas para afrontar sus deudas con los acreedores; por tanto, dadas las deficiencias de la gestión financiera, las empresas no son rentables, lo que impide el crecimiento, la continuidad de sus operaciones o en el peor de los casos el cierre del negocio.
Efectos del nitrógeno líquido y estabilizantes en los parámetros del proceso de elaboración de helado artesanal de fresa
Authors:   , Ibañez Figueroa Ricardo Antonio , Maceda Coello Jennifer
Published: April 2021

En esta investigación se examina el efecto que tendrá el nitrógeno líquido y el tipo de estabilizante en los parámetros del proceso de congelado en la elaboración de helado artesanal de fresa, por medio de la observación directa a 18 muestras que se realizaron en el laboratorio de la universidad San Ignacio de Loyola. La cantidad de nitrógeno se determinó experimentalmente, tomando como referencia los valores obtenidos mediante la fórmula de equilibrio térmico, y los tipos de estabilizante a considerar fueron la goma Guar y goma Xantan, dichos factores tuvieron efecto en el porcentaje de overrun, temperatura final y dureza. Teniendo como resultados que en promedio la goma Guar obtuvo una temperatura final de -6.18 °C y la Xantan -4.79 °C, siendo el objetivo medio de -8 °C. El efecto del estabilizante se determinó midiendo el overrun, mediante una fórmula que compara el aumento de volumen final del helado con el volumen inicial de la mezcla, donde se estableció como óptimo 35%. En este aspecto, en promedio se obtuvo que la goma Guar tuvo un porcentaje de overrun de 43% y la goma Xantan 58%. Y la dureza como una medida practica se concluyó que varía principalmente frente al volumen del nitrógeno utilizado.
The usage of electroimpedancemetry in the diagnostics of acute sinusitis
Authors: Davidov A. V.
Published: April 2021

For the first time in the rhinological practice the methods of evaluation of the functional state of tissues of nasal cavity that were based on registration of their electrical features-electrical resistance (impedance) and potencial were worked out. In the comparative aspect there were researched the active and the passive electrical features of the tissues of nasal cavity which healthy people and those whose disease is acute sinusitis, have. For the first time the dynamic of electrical features was studied and the most informative electrical rates for the initial diagnostic of acute sinusitis and for evaluation of the effectiveness of appointed treatment were revealed. As a result of researches a new way of noninvasive diagnostic of inflammatory diseases of paranasal sinus was worked out, approved and inserted in practice. (Patent № 2157094, 10.10.2000 «The way of diagnostic of inflammatory diseases of paranasal sinus»). The suggested way is simple, reliable; it has high credibility value of revealing the pathologies of paranasal sinus and evaluation of its dynamic. This method may be recommended for the wide usage in hospitals and clinics for diagnostic of acute sinusitis and evaluation of effectiveness of treatment.
Oncomarkers as a factor of risk in the regions with bad ecological situation
Authors: Solomatina T. V. , Kapilevich L. V.
Published: April 2021

By immune-enzyme analysis the content of oncomarkers in serum of blood that exist in people living in the territories of the Tomsk region with bad ecological situation was researched. It was established that practically all people living in the polluted territories have deflections from normal conditions of oncomarkers, but in the control-less than 70%. The deflections on 2 or more oncomarkers in control exist in less than 10% researched people, and in the researched regions-more than 40%.
An experience of making the computerized dactyloscopic program of medical-genetic direction
Authors: Fokin V. A. , Ilyinskikh N. N. , Chantsev A. V. , Kozlov Yu. A.
Published: April 2021

The analytical potentialities of computer dactyloscopic program «Cyberinform» (SSMU, Tomsk) were described. It can be used as an addition to the programs, performing the automatic recognition of the principle dermatoglyphics signs of fingers. One of the main advantages of the mentioned program is an ability to analyze excerpts out of thousands of dactylocards and to compare them between one another, this was demonstrated on the example of Russians and Koreans living in Siberia. The program may be useful to various medico-genetic and anthropo-genetic scientific studies, which up to now were performed by routine methods and took a long time.
The surgery of the focal affections of liver
Authors: Alperovich B. I.
Published: April 2021

In the work the author’s private material devoted to the 40 years experience of the surgical treatment of liver focal affections is analyzed. The methods and the technology of the surgery intervention are discussed and the new methodic of liver resection which was suggested by the author of the work is demonstrated. There is the information about the operative interventions that were for the first time suggested and realized by the author in the cases of the focal affections of liver. The outcomes and far results of the surgical treatment are analyzed. Also there is the information about the benefit to use the new technologies doing the interventions in the cases of focal affections of liver.
The factors of risk of the development of endothelium dysfunction that people with hereditary atherosclerosis and coronary atherosclerosis have
Authors: Kovalev I. A. , Martsinkevich G. I. , Suslova T. E. , Philippov G. P. , Kim V. N.
Published: April 2021

The research is devoted to the evaluation of the depressor and constrictive components of the vascular reactiveness in the people with burdened heredity on atherosclerosis and the factors of risk of this disease’s development. The connection of the vascular reactiveness of peripheral arteries with the factors of risk of atherosclerosis development is discovered. The results of researches allow to suppose that atherogenic factions of lipoproteins, inflammatory cytokines produced by mononuclear of nitric oxide participate in the formation of pathological vascular reactions in people with atherosclerosis and with burdened atherosclerosis heredity on preclinical disease level.
Cell immunity at pregnant women with autoimmune thyroiditis and gestosis
Authors: Makhmuthodzhayev A. Sh. , Ogorodova L. M. , Evtushenko I. D. , Holopov A. V. , Timoshina E. L. , Makhmuthodzhayeva E. V.
Published: April 2021

In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity (n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin. Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16+ NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR+ T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development.
Actual issues of studying of opisthorchiasis in Siberia
Authors: Ilyinskikh E. N.
Published: April 2021

In this article it is overviewed some literature connected with the discovery and scientific description of the trematode Opisthorchis felineus more than a hundred years ago. Special attention has been paid to the relationship between opisthorchiasis and cholangiocarcinoma development in humans. Some data from research literature and the author's own publications illustrated various cytogenetic aberrations in peripheral blood lymphocytes of opisthorchiasis patients have been cited in this article. Such chromosome aberrations were detected more frequently among the new arrivals than the local inhabitants. Many of the chromosome breaks are located near to some cellular oncogenes of the human chromosomes. Superactive biotransformation of some xenobiotics into mutagenic and carcinogenic agents was found in the liver of opisthorchiasis patients. The facts about the distribution of Opisthorchis felineus in Russia are also cited.
How to overcome «the surgical treatment» and not to cut
Authors: Tsesarskaya G. D.
Published: April 2021

The questions of industrial property commercialization in the sphere of medicine are discussed. The reasons according to which the patenting of inventions in the sphere of medicine occurs with legal and financial difficulties are pointed out. The author of the article proposes several ways to overcome difficulties appearing when new preparations, equipment and the methods of treatment are inserted.
Mistakes of diagnostics, conducting and treatments of the patients with bronchial asthma
Authors: Karoly N. A. , Rebrov A. P.
Published: April 2021

On the basis of diagnostics of 100 patients, 25 doctors of Saratov and 72 histories of illness of the patients with severe acute asthma in four different hospitals there were presented the results that prove the great amount of defections in diagnostics quality, conducting and treatment of patients at various stages of rendering of medical aid. There were defined the difficulties of diagnostics and the main factor of severe current of asthma and death. The difficulties are both in absence of primary training of the patients, and in absence of constant, regular supervision of these patients by the local doctor. It is connected not only with the absence of time on doctor’s dialogue with the patient, but also with ignorance and frequently unwillingness of the doctor to learn the modern approaches of conducting and treatment of asthma. The received data confirms that the major factors conducting to increase of severe current of asthma and the increase of mortality are bad diagnostics, inadequate conducting and treatment, and the education of the patients is very necessary part of the general common program of asthma treatment.
The drainage of pancreas area at surgical interferences on it
Authors: Alperovich B. I. , Maryina M. E.
Published: April 2021

On the basis of the analysis of cases 713 patients were revealed postoperative complications because of shortcoming of drainage of pancreas area at surgical treatment of different pancreas diseases. Тhe new method drainage of pancreas area in clinic was elaborated for liquidation of shortcoming offered before methods drainage.
Professor Fedotov N.P. — scientist, teacher, activist (to the 100th birthday)
Authors: Oleynichenko V. F. , Mendrina G. I.
Published: April 2021

The biography of the famous scientist of the Siberian medicine, the first man began studying the history of the Siberian medicine, professor N.P. Fedotov is presented.
Liberties of genome and medical pathogenetics
Authors: Puzyryov V. P.
Published: April 2021

New phenomena in structural and functional organization of the human genome, which turned out to be unexpected for the postulates of classical genetics (liberties of genome) are presented. Modern ideas on forms of inherited variability are given. Participation of new genomic phenomena in pathogenetics and in revealing of new form of human pathology (prion diseases, mitochondrial diseases, trinucleotide repeats expansion, genomic imprinting) is noted. The significance of synthropy conception for the investigation of genetics of common diseases is substantiated. The thesis on the unity of three parts of medicine (social, genomic, and individualized) is put forward.
The mechanisms of activization of endothelium at the pregnant patients with bronchial asthma and gestosis
Authors: Makhmutkhodzhaev A. Sh. , Ogorodova L. M. , Radionchenko A. A. , Evtushenko I. D. , Timoshina E. L. , Tarasenko V. I. , Makhmutkhodzhaeva E. V.
Published: April 2021

At pregnant women with gestosis the increasing of concentration in blood serum of soluble molecules of adherence sVCAM-1 and sICAM-1 is discovered. The same changes are revealed at pregnant with bronchial asthma, the period of gestosis being 18 weeks. With it there is a positive correlation between the substance of soluble molecules of adherence and the concentration of cytokines of atopic inflammation in blood serum.
The methodology of development of computer learning programs in higher medical education
Authors: Karas S. I. , Brazovsky K. S. , Konev A. V.
Published: April 2021

The medicine is weakly formalized domain, and preliminary study of knowledge structure is necessary for computerlearning programs development. Semantic network can be offered as an universal knowledge model for higher medical education. The links between nodes reflect their semantic distance. Graph theory is an adequate tool for knowledge structure investigation, and the results of one prove knowledge models for certain domains and optimal navigation through the program. The last depends on personal features of students, too. So, the basic principles for computer learning programs development in higher medical education are knowledge structure modeling and individual learning navigation.
Will the argues between an employee and an employer come to the end?
Authors: Tsesarskaya G. D.
Published: April 2021

In the article the question of regulation of the relations between the employer and employers is discussed. With the aim to define these relations there was established, inner Thesis about the office inventions in Siberian State Medical University.
The peculiarities of clinic, diagnostic and surgical treatment of opisthorchous cysts of liver
Authors: Alperovych B. I. , Habas G. N.
Published: April 2021

The results of inspection and surgical treatment 38 patients with opisthorchiatic cysts of a liver are investigated. Preoperative diagnostics is based on detection opisthorchiasis and specific ultrasonic attributes of these cysts, opisthorchiatic lesion of hepatobiliary system. The complicated current it were marked at 21% of the patients. Carry out 40 operations, including the resections of a liver. Mortality rate was 5,3%. Developed surgical tactics and technique allows to warn specific complications not reducing radicalism of operations.
Cancer of liver, biliary tracts and pancreas at chronic opisthorchosis
Authors: Brazhnikova N. A. , Tolkaeva M. V.
Published: April 2021

The long-term opisthorchiasis invasion leads to serious complications followed by surgery. Between 1170 patients with O.felineus, undergone an operation at the Tomsk hepatologic center, carcinoma of the liver, bile ducts and pancreas was revealed in 13% of cases. Clinical manifestations of carcinoma are masked by signs of opisthorchiasis for a long time, that leads to the process of a disease of stage III—IV. Ultrasonography and endoscopic methods of examination such fibrogastroscopy, pancreatography, laparoscopy seem to be of great importance in diagnosis. All operations are, mainly, of palliative (57,4%) or explorative (13%) character. Radical operations were made in 10,6% of cases only, laparotomy was of no use in 19% of patients. It is recommended to make a prophylactic medical examination of patients with opisthorchiasis including obligatory ultrasound and endoscopic methods once a year at least, an adequate timely dehelminthization.
Study of diseases prevalence among children in areas of spacerocket activity
Authors: Evlashevsky G. Ya.
Published: April 2021

An objective of this investigation is to study disease prevalence in children residing at territories of falling of separable parts from second stages of space crafts rocket-carriers. The areas of falling and the adjacent areas are the territories of increased ecological risk. The reason is that they are used as dumps for wastes from space-rocket activity: metal fragments of worn-out second stages of rocket-carriers and toxic guarantee remnants of liquid rocket fuel components. In the scope of the study a profound medical examination of children (0—14 years) has been conducted. The main and control group included correspondingly 750 and 312 children. Obtained intensive, extensive and standardized rates of pathological affection have been analyzed (table 1—3). Prevalence rates of pathologies in children residing at territories, adjacent to areas of falling of parts of rocketcarriers, increase significantly the control rates. This fact provides steady scientific claims for discussion of direct association between the observed pathology and prolonged space-rocket activity in the region.
Clinical-genealogical study of patients with chronic obstructive pulmonary disease
Authors: Seitova G. N. , Bogushevich S. A. , Dementjeva E. A. , Nesterovich S. V. , Bukreeva E. B.
Published: April 2021

We present data of clinical-genealogical study of patients with chronic obstructive bronchitis (82 people) and control group (108 people). Study of frequency of lung’s disease in parents and relatives of seek patients and patients from control group revealed the prevalence of bronchopulmonary pathology in the first group in comparison with the second. Study of frequency morbidity depending on the gender of descendents determined the significant prevalence in girls than in boys. Study of type of family burdening in seek patients revealed the prevalence of the type «seek mother, healthy father».
Treatment of the intestinal invagination at children older than 1 year
Authors: Belyaev M. K. , Fyodorov K. K.
Published: April 2021

The aim of research is to show the possibility and efficiency of conservative treatment of intestinal intussusception at the children older than 1 year because on the one hand, there is no common opinion about the tactics of treatment of this disease. On the other hand, during the period of last 10 years the number of children with intussusception has been increasing, running up to 50%. In the hospital from 1976 till 2001 there were 183 children older than 1 year with intestinal intussusception. It is 49.7% of all patients with this disease. The conservative treatment was used for 166 children with precisely determined diagnosis (97.6%). Exsanguinate method of treatment turned to be very effective at 159 patients (95.8%). The treatment failed only for 7 patients (4.2%). So, the possibility and efficiency of conservative treatment at children is demonstrated.
Ultrasonography in diagnosis of sexual development delay of girls and teenagers having diabetes mellitus of the 1st type
Authors: Kondratyeva N. M. , Zavadovskaya V. D. , Kravets E. B. , Gorbatenko E. V. , Strelis L. S.
Published: April 2021

Girls-teenagers (n = 85) aged from 8 to 18 years having diabetes mellitus (DM) of the 1st type were investigated using ultrasonography method. Based upon decreasing and disproportion of the body and neck of the uterus, changed Mecho thickness and ovaries structure, different parameter of blood flow, we worked out classification of the four stages of sexual development delay (SDD) (0 stage in 15 girls, I stage in 26 girls, II stage in 20 girls and III stage in 21 girls). Comparative analysis of clinical and ultrasound studies showed the advantage of ultrasound study to assess status of internal genital organs in girls and teenagers having DM. Investigation performed based upon E. Tanner classification revealed SDD 40 girls, bimanual examination in 45 girls, sonography method — in 82 girls. The given ultrasound classification of sexual development delay in girls-teenagers having DM of the 1st type contributes to diagnosis and prescribing timely effective correction therapy.
To blessed memory of Valentina I. Rybka (09.09.1938 — 16.03.2002). To the 65th birthday
Authors: Guseva G. D.
Published: April 2021

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Dependence between rontgenologic peculiarities of skull bones and hormone abnormalities at women of fertile ages
Authors: Korneeva E. V. , Korchin V. I.
Published: April 2021

In the present work the information about roentgens of skull bones at women of fertile period with polycystosis of ovaries and hypoactivity of thyroid gland is presented. It is revealed that more frequently met rontgenologic factors at patients with this pathology are small turkish saddle, narrowing of entrance in turkish saddle, endocraniosos and craniostenosis.
Retractive reactions of unstriped muscles of auriferous ways at bronchial asthma in the experiment
Authors: Kapilevich L. V. , Dyakova E. Yu. , Sazonov A. E. , Gereng E. A. , Nosarev A. V.
Published: April 2021

Mechanographical method helped to investigate retractive reactions of unstriped muscle оf auriferous ways at bronchial asthma in the experiment that guinea-pigs had. Sensitization of guinea-pigs by ovalbumin leads to the development of hypersensibility to inhalation of this protein with external characteristics of abnormality of bronchial patency. This process is followed by decomposition of epithelium of bronchi, development of immune inflammation in bronchial wall and hypertrophy of muscle layer. In sensibilized beings there was observed the development of hype reactivity of unstriped muscles of auriferous ways on histamine. It appears in histamine of liminal concentration and increasing of maximal amplitude of contraction. Reactions on choline ergine and β2-adrenergine effect didn't change.
Clinic immunological comparison when studying erosive affections of gastro duodenal zone in patients with bronchial asthma
Authors: Chernyavskaya G. M. , Beloborodova E. I. , Perevozchikova T. V. , Pozdnyakov R. A. , Fait E. A. , Degtyarev S. D.
Published: April 2021

The aim of the work is to study the condition of the local immunity of stomach when there is bronchial asthma and the role of affection of some its factors in the formation of gastro duodenal pathology in this category of patients. 302 patients, both male and female were examined in the age of 18—60 with exogenous and mixed bronchial asthma. Gastro duodenal zone of all patients and local immunity of stomach in 65 patients were examined. The condition of the local immunity of the stomach was evaluated according to the content of secretory antibody A (sIgA), antibody G (IgG), circling immune complexes, activity of lysozyme in stomachic secretion. 68 patients (22,5%) have erosive affections of gastro duodenal zone. It is revealed that pathology of gastro duodenal zone is developed with the local deficit sIgA and rise of the content IgG in stomachic secretion. Dose-dependent effect of the long term peroral therapy by the systematic glucocorticosteroids at bronchial asthma on the pathology of gastro duodenal zone and local immunity of the stomach is revealed. Lowering the content of IgG and circling immune complexes in stomachic secretion and immune complex reactions in mucous membrane of the stomach, physiological doses lower the frequency of erosive affections of gastro duodenal zone. Treatment by supraphysiological doses of systematic glucocorticosteroids brings on disruption of specific protection section in mucous membrane of the stomach. It leads to the rise of erosive affections of gastro duodenal zone in this category of patients. Revealed affections of the local humoral immunity of the stomach in the patients have general characteristics and one-directed character of changes with the local immunity of respiratory tract when there is bronchial asthma. It gives the opportunity to suppose the participation of immune system of mucous membrane when having bronchial asthma.
Realization of the ideas of professor I.N. Osipov in the work of Child Diseases’ Department of the SSMU
Authors: Balasheva I. I.
Published: April 2021

There are presented in the article the main ideas of professor I.N. Osipov, that are stated in his monographs, dedicated to the issues of diagnosis. It was described the further development of this ideas in the work of Child Diseases’ Department of the SSMU.
Experimental and clinical ground of using of diquertin and ascorbic acid complex at monopolar ovary coagulation
Authors: Bukharina I. Yu. , Tikhonovskaya O. A. , Plotnikov M. B. , Petrova M. S. , Maslov M. Yu. , Koschevets Ye. S. , Logvinov S. V.
Published: April 2021

There has been conducted a study of morphofunctional ovary changes at monopolar coagulation using histological, histochemical and ultra-microscopic techniques, and there have been evaluated hemorheologic factors and state of lipid peroxidation system (LPS) in postsurgical period. It has been proved that electrocoagulation stimulates the follicle growth for a short time but damages the generative and endocrine ovary apparatus and causes evident hemodynamic changes in perifocal zone. At the same time the raise of blood viscosity and erythrocyte aggregation and LPS activation are occurring. Possessing hemorheologic and antioxidant properties ascovertin produces a protective effect on generative ovary apparatus and microcirculation in it. 48 women after laparoscopic operations on ovaries with the use of electrocoagulation have been examined prospectively. The women of the basic group took the diquertin and ascorbic acid complex prior to and after the surgery in addition to the basic therapy. There has been made an evaluation of LPS factors prior to and after the surgery, computed kymopertubation results and hormonic state in a 1 month after the surgery, frequency of pregnancy beginning. Prescription of diquertin and ascorbic acid complex under the developed procedure is pathogenetically reasonable, it allows to increase the quality of treatment after laparoscopic operations on ovaries and encourages the preservation of reproductive function of a female organism.
The role of IL-5 in eosinophils’ apoptotic death mechanisms in patients with bronchial asthma
Authors: Ivanchuk I. I. , Sazonov A. E. , Petrovsky F. I. , Lescheva I. S. , Kopieva A. P. , Petrova I. V.
Published: April 2021

Investigations of the mRNA expression of apoptosis intracellular regulators, bcl-2 and bcl-xL antagonists and bax, bcl-xL agonists of cellular destruction as well as mRNA expression of IL-5 were carried out. As a result of investigation of potential role of IL-5 in the regulation of programmable bcl-2-dependent destruction we found the increase of vitality and mRNA expression stimulation of bcl-2 peripheral blood eosinophils in patients with bronchial asthma (BA). It was found that fresh-isolated peripheral blood eosinophils in all investigated groups expressed bax and bcl-xL mRNA, bcl-xS had the less activity. In peripheric blood eosinophils of healthy donors the bcl-2 expression was not found, however, the increase of mRNA expression by IL-5 was shown in group of patients with bronchial asthma and, possibly connected with this, the appearance of bcl-2 activity. Thus, the decrease of apoptotic activity in peripheral blood eosinophils in patients with bronchial asthma may lead to the increase of eosinophil portion that is subjected to necrotic destruction and this may significantly contribute into bronchial asthma pathogenesis.
Some theoretical reasons to opening of the faculty of clinical psychology and psychotherapy in Siberian State Medical University
Authors: Kornetov N. A.
Published: April 2021

Current trends of social consciousness and of professional development of psychology in integrative human knowledge are analyzed in this article. Clinical psychology is considered as the field of psychological knowledge having important humanitarian and practical significance in joint development with clinical specialties in medical university.
Search of ways of pharmaceutical enterprises taxation optimization
Authors: Drugova Z. K.
Published: April 2021

The goal of the present investigation is the study and assessment of taxation efficiency for pharmaceutical enterprises dealing with medicine retail.
View on mechanical solidity of anastomosis
Authors: Aliev F. Sh. , Chernov I. A. , Molokova O. A. , Ketcherukov A. I. , Gunter V. E. , Baradulin A. A.
Published: April 2021

In modern abdominal surgery purulent septic complications are the main reason of lethality in postoperative period. At the same time the problem of surgical suture reliability of large intestine remains very actual. Different methods of study of anastomosis physical containment (such as pneumo-, hydro-pressure, study of intestinal wall rupture force) are used for evaluation of the quality of formed anastomoses. In literary review there is a comparative description of different methods of anastomosis mechanical solidity determination; the self-descriptiveness of these methods, their advantages and disadvantages are analyzed; questions of study of large intestine anastomosis elasticity are discussed.
About two kinds of antithrombotic monitoring
Authors: Barkagan Z. S.
Published: April 2021

The modern methods of monitoring of therapeutic and prophylactic application of antiaggregants, anticoagulants and thrombolytic agents have been examined. Their application allows to optimize the drug doses and prescription terms.
25 years of biophysics and functional diagnostics Department in Siberian State Medical University
Authors: Baskakov M. B. , Kapilevich L. V.
Published: April 2021

Here is presented the history of biophysics and functional diagnostics Department creation in Siberian State Medical University, names of chair’s founders are given. The main directions of activity and scientific achievements are defined.
Experience and prospects in medical personnel informational training in IATP Center of SSMU scientific medical library in Tomsk
Authors: Zakharova G. V. , Molodtsova N. V.
Published: April 2021

Training of users in SSMU scientific medical library is made on the basis of Internet Public Center that has been opened under the support of non-profit American corporation – “Project Harmony, Ink”. The teaching programs have been developed, subject seminars, courses and trainings are conducted. Graduates of change programs take part in the teaching process. The system of medical users training organization promotes the use of Internet resources as a source of medical and lawful information.
Maksar hepatoprotector is an effective corrector of prednisolone immunosuppressive action at experimental toxic hepatitis
Authors: Vengerovsky A. I. , Ogorodova L. M. , Perevozchikova T. V.
Published: April 2021

Polyphenol containing hepatoprotectors — maksar (complex of isoflavones and stilbenes of Far East plant — Maaсkia amurensis Rupr.et Maxim.) and legalon — during combined introduction with prednisolone to rats with chronic hepatitis, caused by tetrachloromethane, weaken the immunosuppressive action of glucocorticoid – augment the blood lymphocyte quantity, prevent the thymus atrophy, increase the blasts and antibody-forming cells content in spleen and the functional activity of with C3b-receptors in peritoneal exudation.
Epiphysis morphology under light and radiation exposure in experiment
Authors: Logvinov S. V. , Gerasimov A. V. , Kostyuchenko V. P.
Published: April 2021

Epiphysis is an organ of the control of biorhythms and adaptogenesis connected with photoperiodism. To evaluate photoradiomodificating effect and conarium plasticity using the methods of light and electron microscopy, there have been analyzed changes in morphological indices of pineal secretion activity in white rat males after 48-hour bright light exposure, general X-ray exposure and its combination. The received results have been handled by the method of variation statistics. It has been revealed that the decrease of light pinealocyte part, its protein-synthesizing system reduction, reparative activity decrease and the increase of degenerating pinealocyte part after combined exposure were expressed more significantly as compared to the light and X-ray exposures.
Peculiarities of myelodysplasia syndrome course of children
Authors: Balasheva I. I. , Luchinina R. N.
Published: April 2021

In the article there has been presented a brief knowledge of the main forms of myelodysplasia syndrome (MDS) of adults and children and the peculiarities of its course. Approaches to the modern therapy and its outcomes have been discussed. Abstract of case history of the child observed in the clinic has been cited.
Modern health care priorities for workers of nuclear and radiation dangerous industry
Authors: Syomin I. R. , Vasilyev A. A. , Trufanova I. Yu. , Kurbat I. I. , Bulasheva Z. M. , Starodumova T. A.
Published: April 2021

An investigation has been carried out with the aim to reveal the main causes of temporary disability, invalidism and mortality of Siberian Chemical Combinat (SCC) workers. There has been made an analysis of medical statistics data of the Central health department No 81 for the period of 1951-2001 and of results of psychophysiologic examination of workers in SCC nuclear- and radiation-hazardous areas. Investigations have revealed that a radical (up to isolated instances) decrease of professional pathology occurrence caused by radiation and harmful chemical substance influence had taken place within 50 years of SCC functioning. Today psychosomatic disorders are the main cause of temporary disability, invalidism and mortality of nuclear- and radiation-hazardous plant workers. Psychosomatic disorders occurrence and economic loss connected with it allow to specify the psychophysiologic support laboratories work on revelation and correction of inadaptation states at atomic industry workers as priority.
Analysis of neonatal mortality in Tomsk
Authors: Tropova T. Ye. , Krivonogova T. S. , Matveyeva L. A. , Zlobina R. A.
Published: April 2021

Dynamics of neonatal mortality in Tomsk within the period of 1999—2001 has been analyzed in the article. Analysis has been made according to the T. Kern’s method by G.S. Muchiyev’s and O.G. Frolova’s modification. This method permits to evaluate the dynamics of neonatal mortality from the viewpoint of its averting and gives opportunities to reveal the errors at all stages of medical care of women and new-born children. 170 cases of neonatal deaths have been analyzed. There has been marked the decrease of both early and common neonatal mortality due to avertable reasons. Unavertable death reasons tend to increase due to congenital malformations. Ways of the further decrease of neonatal mortality have been defined.
Popov Mikhail Andreyevich (1903—1986). To the 100th birthday
Authors: Ivchenko O. A. , Fominykh S. F. , Mendrina G. I. , Gribovsky M. V.
Published: April 2021

The biography of an honored doctor of RF, a head surgeon of Tomsk region (1953—1967) and a reader of Tomsk Medical Institute (today SibSMU) M.A. Popov has been presented.
Department of obstetrics and gynecology of the Siberian State Medical University. I.N. Grammatikaty (1858—1917). To the 145th birthday
Authors: Yevtushenko I. D. , Radionchenko A. A. , Kharitonova Ye. M.
Published: April 2021

The biography of an outstanding scientist, a founder of the chair of obstetrics and gynecology, an ordinary professor of the Emperor’s Tomsk University (now SibSMU) I.N.Grammatikaty, one of the creators of Russian obstetric and gynecologic literature, has been presented in this article. Here are presented materials reflecting the formation and development of the chair of obstetrics and gynecology and the main scientific achievements of the chair for the last 10 years.
Effect of polyphenol-containing hepatoprotectors on functional liver morphology during experimental Reye’s syndrome
Authors: Shamardina L. A.
Published: April 2021

During experimental Reye’s syndrome caused in rats by 4-pentenoic acid, histoarchitectonics disturbances, circulatory disturbances, microvesicular steatosis, necrosis in central lobule part have been developed, number of 2-nucleus cells has been decreased, activity of mitochondrial, lysosomal and cytoplasmic hepatocyte enzymes has been disturbed. Hepatoprotectors of polyphenol nature — lochein, maksar and legalon — used for experimental Reye’s syndrome therapy, have regenerated a normal liver histologic structure, decreased the microvesicular steatosis and the quantity of necrotizing parenchyma cells, stimulated the regeneration and increased the activity of intracellular hepatocyte enzymes. Lochein and maksar possess the most therapeutic activity.
Laboratory medicine: from student days to clinical practice
Authors: Ryazantseva N. V. , Kulagina I. V. , Radzivil T. T. , Kovalyova N. P.
Published: April 2021

A problem of interaction of laboratory diagnostics specialists and clinicians in diagnostic and treatment processes has been raised. The viewpoint of authors on the expediency of laboratory medicine fundamentals teaching in doctors’ faculties of medical colleges has been presented.
Prediction of remission resistance at endogenous mental disease: outlooks of functional diagnosis use
Authors: Bobrovskaya N. V.
Published: April 2021

Results of research of 83 patients with schizophrenia and affective disorders show, that some components of the functional diagnosis can serve as predictors to stability of remissions. Social characteristics — family and concerning to the nearest environment outside of family are most significant in this respect.
Evidential approaches to the knowledge investigation in the higher medical education
Authors: Karas S. I.
Published: April 2021

In the article the point of view of medical knowledge as an object of investigation with certain properties has been presented. Evidential approaches to such investigation included analysis and synthesis of knowledge and were supported by the developed computer programs. The higher medical education has been viewed as the dynamics of students’ knowledge model.
Peculiarities of depressive disturbances at cerebral stroke with different lesion focus localization (by neuro-imaging method data)
Authors: Katayeva N. G. , Levina A. Yu.
Published: April 2021

The aim of investigation has been a specification of affective disturbances at patients in acute stroke period depending on the lesion focus. Affective disturbances have been revealed by imaging methods — computed and magnetic resonance tomography (CT or MRT). 72 patients with strokes have been examined (41 women and 31 men). Affective disturbances have been evaluated according to criterions and have been specified with depression self-concept scale of Beck. During the investigation the following conclusions have been made: 1) depressive disturbances of all the patients have had the character of light depressive episode (average mark by Beck scale — 22,14 ± 1,59); 2) depressive disturbance frequency have been significantly greater at stem structure damage than of the right (p < 0,001) and left (p < 0,05) hemispheres; 3) depressive disturbances have been revealed more frequently at single persons (p < 0,05).
Resources of cryodestruction in the treatment of hepatocirrhosis
Authors: Alperovich B. I. , Orlov A. V. , Kiselyova Yu. V.
Published: April 2021

The aim of investigation was to evaluate the liver cryodestruction effect on the course of chronic hepatitis and hepatocirrhosis. Experimental part of the investigation has been fulfilled on 220 white mongrel rats with toxic hepatocirrhosis caused by carbon tetrachloride. Evaluation of hepatic parenchyma state has been done by the following criteria: factor of parenchyma normalization and factor of sclerotization. The comparison of these factors in the basic and control groups has revealed an evident positive dynamics in normalization of histological hepatic structure.