bluuebunny/crossref_metadata_2025 huggingface dataset:
Penguatan Nilai-Nilai Keagamaan Dalam Rangka Membentuk Perilaku Jujur dan Bertanggung Jawab di Rumah Asuh Yabni Padang
Authors: Usman  , Devi Syukri Azhari  , Ashabul Fadhli
Published: July 2023

The value of honesty is an important value that should be taught by every student in school, both through learning in the classroom and outside the classroom. Instilling the value of honesty is intended so that students understand the importance of this value in every aspect of life. Honesty is an important capital for students to become the next generation of the nation in the future. Honesty is one of the most valuable values ​​in life. Fostering and instilling the values ​​of honesty is then carried out in the family environment and must be done as early as possible so that it affects the growth and development of children. Through fostering and instilling the values ​​of honesty in accordance with human values ​​in each individual in the family, a peaceful and prosperous civilization will be created. Because after all education in the family has a strategic value in the formation of a child's personality. since childhood children have received education from both parents through exemplary, honesty, and good daily living habits in the family. Whether or not the example given by parents is good and how the daily living habits of parents in the family will affect the development of the child's soul.
Peran Guru dalam Membentuk Karakter Peserta Didik pada Siswa Kelas III MI Al-Irsyad Kota Tangerang
Authors: Magdalena Ina , Nurcahyati Aan , Sakina Syera Putri , Azahra Azma , Rohmadona Adelia , Nabila Putri , Anggraeni Rika
Published: July 2023

This  article  aims  to  look  at  the  role  of  teachers  in  shaping  the  character  of  students  in public  elementary  schools.  This  study  uses  a  qualitative  approach  with  data  collection techniques  of  observation,  interviews  and  documentation.  The  data  validity  analysis techniques used were triangulation, observation extension and increased persistence. The results of this study found that the teacher's role is very strategic in shaping the character of  students  because  the  teacher  is  not  only  a  person  who  teaches  character  values to students  theoretically  but  the  teacher  also  provides  an  example,  so  that  it  is  relevant between what is conveyed and what is done by the teacher.. So that it has a very positive impact on the formation of the character of students.
The Role Of Teachers In Embedding Islamic Values And Ethics In Education: A Literature Review
Authors: Ihwani Siti Suhaila , @ Jima'ain Muhammad Talhah Ajmain , Rashed Zetty Nurzuliana
Published: July 2023

The purpose of this paper is to investigate the role of teachers in embedding Islamic values and ethics in education. The rationale of this study is by understanding how Islamic Education teachers should play their roles in embedding Islamic values and ethics, could perhaps contribute to better ways of students’ behavior development. In this regard, the study has focused on exploring how the roles of  Islamic Education teachers, and the challenges that affect the teachers in promoting Islamic values and ethics in education. The study used a library research design. The data were collected from research articles published in either international or national accredited journals. The research findings show although the elements of Islamic values and ethics seem to be discussed in Islamic Education, students show low Islamic values and ethics in their behavior. The study recommends several approaches to improve the teaching of Islamic values and ethics in schools which include training for teachers to improve the methodology of teaching and providing teaching and learning facilities. It is also suggested that an open discussion is conducted between parents, teachers, students, policymakers, and religious leaders to develop a guideline on what should be included in the syllabus and how to cultivate Islamic values and ethics in education effectively.
 
Keywords: Role Of Teacher, Islamic Values, Ethics
Myeloproliferative neoplasms in 2022
Authors: Maze Dawn
Published: July 2023

The Philadelphia chromosome(Ph)-negative myeloproliferative neoplasms (MPN) are comprised of a heterogenous group of disorders of myeloid hematopoietic stem cells that include polycythemia vera (PV), essential thrombocythemia (ET), and idiopathic myelofibrosis (MF). MPN are characterized by constitutional and other disease-related symptoms, an increased risk for thrombotic and hemorrhagic events, and a propensity to transform to acute myeloid leukemia (AML). Progress in our understanding of the molecular pathophysiology of MPN has led to improved prognostic tools, and increasingly personal risk-stratification. In PV, there has been renewed interest in interferon (IFN) for its potential to directly target the malignant clone and exert a disease-modifying effect. In MF, the introduction of Janus Kinase (JAK) inhibitors has significantly altered the therapeutic landscape over the past decade. Ongoing development in the area of JAK inhibitor therapy, as well as several novel pathways, holds promise for improved hematologic responses, lessening of overall burden of illness, increased quality of life, and application to a broader cohort of patients.
Diagnosis and treatment of AL amyloidosis in 2022
Authors: Jimenez-Zepeda Victor H.
Published: July 2023

Light chain (AL) amyloidosis is a rare, progressive and typically fatal disease (when advanced) characterized by organ dysfunction secondary to deposition of misfolded fibrils of immunoglobulin light chains that are produced by clonal plasma cells or B cells. Although less than 10% of AL patients qualify for CRAB criteria of symptomatic myeloma (Calcium elevation, Renal dysfunction, Anemia, and Bone disease), the majority of these patients have significant impairment of vital organs, such as the heart, kidney and liver. This implies that the common risk factors used for the assessment of multiple myeloma (MM) are not applicable to AL. AL amyloidosis affects 8–12 individuals per million person-years, and its clinical presentation is variable depending on the extent and number of vital organs affected. The locations of amyloid deposits can vary among patients, thus contributing to the heterogeneity of the clinical manifestations. The heart and kidney, which are the most affected organs, can lead to renal failure, cardiomyopathy, and pericardial and pleural effusions. Initial symptoms at onset are often non-specific (e.g., weight loss, fatigue). Despite advances in the diagnostic tools and treatment options, early mortality rates remain high; the expected one-year mortality is approximately 30%. Unfortunately, by the time the AL diagnosis is made, and treatment is initiated, the disease has often become advanced.
To transplant or not to transplant in multiple myeloma
Authors: LeBlanc Richard
Published: July 2023

Multiple myeloma (MM) is the second most common hematologic cancer resulting from proliferation and accumulation of abnormal plasma cells (myeloma cells) with a preferential homing in the bone marrow. It causes significant morbidity including lytic bone lesions, renal insufficiency, anemia, and infections, to name just a few. Although MM remains largely incurable, it is a chemo-sensitive disease. The use of high-dose intravenous melphalan (100-140 mg/m2) in the treatment of MM was first studied almost 4 decades ago.Subsequently, the dose of melphalan was increased and was followed by autologous hematopoietic stem cell to decrease the aplasia-associated toxicity. Results from phase 3 studies comparing chemotherapy alone to chemotherapy followed by high-dose melphalan and autologous stem cell transplantation appeared in the mid-90s with the publication of the IFM-90 study demonstrating significant clinical benefits on response rate, event-free survival and even overall survival in a cohort of two hundred previously untreated patients under the age of 65 years. This landmark study was followed by confirmatory studies in the early 2000’s. Within the last 2 decades, although improvement in the treatment of transplant-eligible patients is mostly the result of better induction regimens and due to the addition of maintenance therapies, autologous stem cell transplantation remains a cornerstone treatment for MM patients. Indeed, despite novel and more effective treatments for MM, autologous stem cell transplantation continues to demonstrate clinical benefits (Table 1). Moreover, tandem autologous transplantation has demonstrated progression-free survival and overall survival benefits for some patients with poor risk cytogenetics.

In 2022, with better knowledge of MM, awareness of potential consequences of high-dose melphalan and with novel and more effective treatment modalities, the role of autologous stem cell transplantation is certainly becoming a question for debate. The purpose of this article is to present the pros and cons of autologous stem cell transplantation in our Canadian reality (Figure 1). This article aims to better assess its role as a therapeutic option considering our health system’s limited resources in which many novel drugs will not be available/accessible in Canada for several more years to come.
With great power comes great responsibility: Managing side effects of novel treatments in chronic lymphocytic leukemia (CLL)
Authors: Banerji Versha
Published: July 2023

The treatment paradigm shift in CLL has uprooted many clinicians’ standard practices. Previously, treatment largely depended on age, organ function and “fitness” based on clinical trials which used CIRS (cumulative illness rating scale) scores. Today, as a hematologist who mainly treats patients with CLL, treatment strategies are more complex and multi-factorial. Treatments are based on molecular profiling, which aids in the identification of lower-risk patients for time-limited treatment options versus higher-risk patients (IGVH unmutated, del 17p or TP534 ) who benefit from continuous therapies. The highest-risk patients can be identified using a staging system for CLL known as the CLL-International Prognostic Index (CLL-IPI). However, increased CIRS scores are prognostic for poor outcomes independent of the CLL-IPI. As a result, selecting the right treatment for the right individual has never been more important, especially in the era of novel therapeutics. This treatment selection decision pathway includes understanding both patient factors and medical factors that may influence patient outcomes.
Navigating challenging treatment decisions in relapsed and refractory multiple myeloma (RRMM)
Authors: Louzada Martha , McCurdy Arleigh , Pavic Michel , Venner Christopher
Published: July 2023

Treating relapsed and refractory multiple myeloma has been challenging, due to a lack head-to-head trial comparisons of the various available regimens and poor cross-Canada access to currently approved regimens. New therapeutic combinations in this setting open up more options to consider, and also the possibility of greater efficacy and more judicious use of available drug classes to avoid resistance. Oncologists shared insights on how they choose between these therapeutic regimens for various patient subgroups.
EKONOMSKE SLOBODE I EKONOMSKI RAZVOJ: OSVRT NA INSTITUCIONALNI OKVIR
Authors: Marošević Katarina
Published: July 2023

Suvremeni trendovi određeni su brojnim nejednakostima, i to neovisno o razini razvijenosti nacionalnog gospodarstva. Ekonomski teoretičari, ali i teoretičari brojnih drugih znanosti, među ostalim, navode neoliberalne politike i globalizaciju jednim od uzroka nejednakosti. No, liberalizam se obično veže i uz više ekonomske slobode, a posljedično upućuju na razvijenija gospodarstva. S druge strane, niže razine ekonomskih sloboda upućuju na problem manje ekonomske razvijenosti, a popratno i društva koja „pate“ od brojnih neravnoteža. Pitanje djelovanja ekonomskih sloboda u zemljama srednje i istočne Europe vezan je uglavnom uz problematiku prihvatljivog institucionalnog djelovanja. Dakle, institucionalna (ne)razvijenost u zemljama srednje i istočne Europe nerijetko se pojavljuje kao mogući uzrok, ali i posljedica nerazvijenosti gospodarstava. Stoga je cilj ovoga rada analizirati, rangirati i usporediti nejednakosti u izabranim zemljama EU27 prema grupi vladavine prava kao jedne od četiri grupe pokazatelja ekonomskih sloboda izraženog indeksom ekonomskih sloboda, imajući u vidu kako vladavina prava utječe na djelovanje institucija i institucionalnog okvira. Ujedno se daje uvid u odstupanja zemalja srednje i istočne Europe u pokazateljima kategorije vladavine prava i pokazatelja integriteta vlade u odnosu na razvijene zemlje sjeverne i zapadne Europe.
MOĆ SOCIJALNOG PODUZETNIŠTVA U NAPRETKU DRUŠTVA
Authors: Tolušić Marija , Haršanji Maja , Kujek Dora
Published: July 2023

Cilj je ovoga rada prikazati ulogu i utjecaj socijalnog poduzetništva u razvoju zemalja Afrike te ujedno otkriti može li ono biti jedan od ključnih čimbenika za razvoj siromašnih država, društava i zajednica. U radu su obuhvaćeni teorijski aspekti socijalnog poduzetništva, a dodane su povijesno važne činjenice kako bi se prepoznalo što je dovelo do trendova danas i što će dovesti do potencijalnih trendova u budućnosti. Metodologija rada temelji se na pregledu relevantne i recentne literature, a empirijski dio na prikazu rezultata provedenog dubinskog intervjua s dvoje ispitanika. Ovim se radom otkriva važnost fenomena socijalnog poduzetništva, socijalnih poduzeća i socijalnih poduzetnika u državama Afrike. U empirijskom istraživanju potvrđuje se da je socijalno poduzetništvo jedan od ključnih čimbenika za razvoj i napredak država na afričkom kontinentu te da ključna uloga u pokretanju socijalnih promjena i rješavanju društvenih problema pripada lokalnom stanovništvu iz kojega se onda prelijeva na sve razine društva i države.
ESCALAS DE MENSURAÇÃO E ANTECEDENTES MOTIVACIONAIS DE AMBIENTES VIRTUAIS DE APRENDIZADO FOMENTADOS PELA INTELIGÊNCIA ARTIFICIAL
Authors: Bertoncini Ana Luize Correa , Serafim Mauricio Custódio , Borba Eduardo Henrique de
Published: July 2023

A aplicação da Inteligência Artificial (IA) desenvolveu os Ambientes Virtuais de Aprendizado (AVAs) e agregou valor às formas tecnológicas de ensino. Estes ambientes on-line se revelaram essenciais em situações inesperadas, como a pandemia de Coronavírus (COVID-19). Sendo assim, neste artigo, apresenta-se um levantamento bibliográfico sistemático e uma análise semi-sistemática de escalas que avaliam AVAs fomentados pela inteligência artificial, focando nos antecedentes de adoção e na análise das escalas. Os resultados, provenientes das bases de dados Web of Science, Science Direct, Springer Link, Emerald Insight e EBSCO Host, são expostos mediante análise quantitativa descritiva e avaliação comparativa das escalas. Os resultados evidenciaram escassez de escalas que avaliem os AVAs, e os poucos artigos que as fazem carecem de rigor em etapas iniciais de desenvolvimento. Destacou-se também dimensões referentes a percepção dos estudantes que antecedem a adoção destes ambientes virtuais, evidenciando assim elementos determinantes da motivação dos estudantes on-line.
A GAMIFICAÇÃO NA PESQUISA ALFABECLICANDO
Authors: Vales Luciene de Sousa Teixeira , Porto Maristela da Cunha , Martins Thais da Cruz , Lacerda Maisa Caroline Carvalho dos Anjos , Santos Lorrayne dos , Costa Kamila Melo de Oliveira
Published: July 2023

Este trabalho reflete sobre a organização de oficinas de Reforço Escolar que utilizam a Metodologia Ativa da Gamificação como estratégia pedagógica de atendimento a crianças com defasagem de leitura e de escrita, no período pós-pandemia. Apresentamos o processo de construção da teoria da Gamificação, aplicada a práticas pedagógicas em oficinas de reforço escolar, nas quais são desenvolvidos jogos reais e jogos digitais educativos. Esta análise é parte da Pesquisa em andamento: Alfabeclicando: Reforço Escolar de Alfabetização com Uso de Games Educativos, que está sendo desenvolvida pelo Instituto Superior de Educação do Rio de Janeiro (ISERJ), vinculado à Fundação de Apoio à Escola Técnica do Estado do Rio de Janeiro (FAETEC) e a Secretaria Municipal de Educação do Rio de Janeiro (SME/RJ), representada pela sua unidade Ginásio Experimental Tecnológico (GET) Elza Soares, com apoio e fomento da Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Embora a pesquisa ainda esteja em andamento, podemos constatar que é possível que a escola se utilize dos Games e da Gamificação em contextos de reforço escolar para alfabetização, entendendo que ele é parte da cultura humana e por isso também parte da cultura infantil. E que a Metodologia Ativa da Gamificação possibilita a integração de todas as ações, contextualizando, de forma lúdica, o aprendizado das crianças participantes.
DECOLONIALIDAD PLANETARIA DE LA IDENTIDAD
Authors: Rodriguez Milagros Elena , Lemus Maestre José Gregorio
Published: July 2023

Como objetivo complejo de investigación sustentamos la decolonialidad planetaria de la identidad del colonial con la intencionalidad de la liberación del ser humano. Ubicada en las líneas de investigación: Decolonialidad planetaria-complejidad en re-ligaje y transepistemologías de los conocimientos-saberes y transmetodologías transcomplejas. La deconstrucción rizomática hace escena como el transmétodo de la pesquisa. Des-ligándonos con ellos de las taras que pululan como instrumentos de soslayación en el proyecto decolonial para li-gar a ejercicios liberadores en la identidad del ser humano. En la reconstrucción mostramos que aceptar nuestra constitución compleja: naturaleza-mente-alma-cuerpo-Dios, no está desligada con ser científico, Dios es dador de ciencia y nos re-liga sabiamente a ello; respetando la naturaleza de la creación. Identifica así portador de una identidad decolonial planetaria digna, en la que se sabe que contrariamente al humanismo caducado cruel, en él no está su salvación; que siendo finito su cuerpo, y no habiéndose creado a sí mismo no debe violar la naturaleza de su vida. Pero debe cuidarse anhelantemente, pues se sabe templo del Espíritu Santo, la persona ayudador que envío Dios para guardarlo cuando Jesucristo ascendió a los cielos. La decolonialidad planetaria desde luego se sube en hombros de gigantes de grandes decoloniales de la historia: el primero y único salvador y liberador: Jesucristo de Nazaret; de investigadores como Paulo Freire, Nelson Mandela, entre otros; que no se liguen a posturas marxistas caducadas que han mostrado con el socialismo, castrismo, comunismo, hitlerianismo, capitalismo y otros; un profundo desprecio por la vida, han empoderado el ser humano hacia su perdición. O las politiquerías paternalistas que hacen sentir al ser humano participen de sus riquezas y decisiones para llevarlo a ejercer ideologías únicas, donde la democracia deja mucho que desear.
Comparison of Titanium Dioxide-containing and Titanium Dioxide-free Film Coating Systems
Authors: Lawrence Simon , James William A , Stewart Sarah
Published: July 2023

Titanium dioxide (TiO2) is an important white pigment and opacifier that has been used in the pharmaceutical industry for over 50 years. It has been included ubiquitously in coloured coating systems and therefore many medicines. Its use in oral solid dosage forms, however, is now under scrutiny due to data linking TiO2 particle inhalation with DNA damage. This also caused the European Union to ban its use as a food additive. Consequently, material suppliers have launched several TiO2-free (TF) pharmaceutical coatings. In this study, two TF coatings based on different pigments were compared with a traditional TiO2-containing coating assessing covering and colour quality. The TF coatings both showed a comparable quality in these parameters to the TiO2-containing coating. The differences in colour and the degree of whiteness were also quantitatively measured and compared using CIELAB measurements derived from optical lens readings. The colour analysing tool used limited this data.
Assessment of the Opacity of Titanium Dioxide Free Film Coating Formulations
Authors: Tee Alyson Hui Ling , Ogden-Barker Michaela , Sproston Kieran Ellis
Published: July 2023

Titanium dioxide (TiO2) iswidely used as an excipient in pharmaceutical film coating formulations. InAugust 2022, the European commission (EC)adopted a ban on the use of TiO2 (E171) as a food additive.There is uncertainty around the implications of this decisionon pharmaceutical products, and a potential need to find suitable alternativesto TiO2. Inthis study, we evaluated the opacity of the different TF film coating systemsby assessing the ability of TF film coatings tomask coloured tablet cores at varying weight gains.HPMC-based film coatings containing CaCO3 demonstratedthe best covering potential and were positively correlated to the amount ofCaCO3 present, while PVA-based film coatings containing CaCO3showed poor coverage, even at 9% weight gain. 
Model Informed-Development of Amorphous Systems (MI-DAS) - an in-silico polymer selection tool for ASD development
Authors: Roberts Elen , Rahman Sadiyah , Ahmed Shajee , Dickinson Harri , Gajjar Parmesh , Austin Talbir , Budhdeo Shanoo , de Matas Marcel , Stott Paul
Published: July 2023

Forming amorphous solid dispersions (ASDs) is one method for improving the solubility and subsequent absorption of poorly-water soluble drugs. An ASD is a matrix of a poorly water-soluble compound with a hydrophilic polymer carrier, which stabilises the drug in its amorphous form. The choice of polymer is often made based on previous success and precedence in other ASD products, and not on the suitability for the drug in development. A bespoke in-silico polymer selection tool (PST) has been developed which selects polymers based on their structural complementarity with the drug. Here, we demonstrate how use of the PST in early development of the Tacrolimus ASD would have identified a more optimal polymer with better API miscibility.
Digital Design of Crystallization Process: Why particle size and shape matters!
Authors: Taylor Robert
Published: July 2023

Populationbalance modelling is a widely used tool to understand the mechanism and kineticparameters of crystal growth at the bench, to facilitate scale-up to Production.In this work, we present recommendations for particle size and shape analyticalmethods to improve the predictive capability of 1D and 2D population balancemodels for crystallisation of contemporary active ingredients. For 1D models, wereport that the optical model for laser diffraction, a common technique formeasuring particle size distribution, can significantly impact the growth parametersresolved from the model. For 2D models, particle image analysis of powders andsingle crystals give valuable length and width data to predict how the aspectratio of particles evolves. Future work will be directed towards applying thesetools when scaling a crystallization process.
Dar Gelirliler İçin Toplu Konut Üretiminde Katılımcı Tasarım Modeli: Van Kenti Örneği
Authors: Gülen Mustafa , İncedayı Deniz
Published: July 2023

Konut meselesi 20. yüzyıldan bugüne küresel ve yerel ölçekte tartışılırken, mimarlık alanında yapı üretiminin organizasyon, tasarım ve sunum biçimleri toplumsal değişim ve dönüşümler sonucu farklılaşarak kullanıcı katılımı ön plana çıkmıştır. Türkiye’de özellikle 2000’lerden sonra TOKİ’nin konut üretiminde yeni’ bir aktör olarak yer almasıyla, konutun anlam ve üretim biçiminin değişime uğradığından bahsetmek mümkündür. Bu çalışmada, günümüz dünyasında ve mimarlık alanında güncel tartışma konuları olan toplu konut, kullanıcı’, mimari tasarımda katılım’ vb. kavramlar TOKİ’nin Van kentinde inşa ettiği binlerce konut birimi üzerinden örneklendirilmiştir. Çalışmada ayrıca dar gelirliler için toplu konut üretiminde uygulanabilecek, kullanıcı katılımlı esnek bir model önerisi yapılmıştır. Bu modelin dar gelirliler için toplu konut üretiminde ve bu alanda yapılacak diğer çalışmalara bir altlık oluşturması amaçlanmaktadır. Çalışmanın yöntemi 2011 Van depremi sonrası yerinde yapılan gözlemlere dayalı tespitlerdir. İlgili literatür taranmış, kullanıcılar ile sözlü görüşmeler ve anket çalışması yapılmış, toplu konut alalarına ilişkin çizim ve görsel belgeler incelenmiş, yapılan tespitler fotoğraflar ile görselleştirilmiştir. Bu haliyle toplu konut üretimini betimleyip irdeleyen ve mevcut deneyimler ve birikimler üzerinden sentez bir model öneren çalışma, konut üretiminde giderek yaygınlık kazanan kullanıcı katılımlı tasarım’ literatürüne de bir katkı olarak görülebilir. Çalışma sonucunda dar gelirliler için toplu konut üretiminde yeni’, farklı’ bir üretim modelinin mümkün olabileceğinin anlaşılması beklenmektedir. Kentlerin çok yönlü etkenlere bağlı olarak yaşadıkları değişimde, yapılaşma süreçleri önemli bir yer tutar. Tekil olarak üretilen konutlar, özellikle nüfus artışına bağlı olarak gelişen toplumsal, ekonomik, siyasal dinamiklerle birlikte yerlerini kitlesel üretime bırakmış ve dönüşümün izleri fiziksel çevrede ve toplumsal yaşamda yansımalarını bulmuştur.
Multiple Meanings of Child Participation in Architecture and Planning: Revisiting the Participation Ladder
Authors: Altınbaşak Haklıdır Ece , Orbey Betül , Şahin Pınar
Published: July 2023

In literature, there are numerous studies on child participation and the levels of participation. However, the levels of child participation are categorized with different approaches among these studies. The aim of this article is to make a comparative analysis by examining the literature on the degrees of child participation and to systematize the concepts. Therefore, (i) bibliometric analysis and thematic mapping methods were conducted to identify various themes in academic studies in the field of child participation to understand the conceptual structure of the relevant literature that has changed over time; (ii) initiative reports suggesting different frameworks regarding participation degrees were also examined. These studies were categorized according to their definitions of participation degrees in a table. The table was structured from the lowest level of participation to the highest level, under three main typologies: non-participation, low-level participation, and true participation. It has been observed that all studies are concerned with ethical distinctions at the base level; consider lower levels of participation; and define methods that they consider as true participation. It was found that the levels and definitions in some studies were more inclusive and included several levels of participation simultaneously. However, the active participation of children in the processes and clarifying their actual roles are still vague issues. This study clarifies the boundaries of child participation in literature and serves as a basis for future studies investigating the degree of child participation in projects, which will help to uncover and develop the nature of practices involving child participation.
Reclaiming the “Cultural Mandate”: The Idea of Sustainable Development in the Kantian Perspective
Authors: Chaly Vadim A.
Published: July 2023

In the Club of Rome report Come on! Capitalism, Short-Termism, Population and the Destruction of the Planet (2018) Kant, along with other “old” Enlighteners, is presented as the father of a world-view which led to the destabilisation of the environment in which humanity exists. The authors of the report argue that the “old Enlightenment” with its individualism, faith in the market and a consumerist attitude to nature should be scrapped. I maintain that this assessment of Kant’s philosophy is groundless and that his ideas allow us both to conduct a more profound diagnosis of the crisis and to propose a more solidly founded strategy of overcoming it. First, I sum up the position of the authors concerning the loss of sustainability of development which they attribute to the philosophy of Enlightenment. Next, I outline the history and content of the notion of “sustainable development” and offer an analysis of the sources of progressivist commitment to the conquest of nature which lie outside Modern Times in the idea of the “cultural mandate”. Then I present the Kantian diagnosis of the causes of the crisis which attributes it to humankind’s failure to “mature”. I compare the idea of “the full world” formulated by the authors of the report with the idea of the “the world come of age” and their diagnosis of “capitalism — short-termism — depletion of resources” with the Kantian assessment of the attempts to escape from the predicaments of the present into the past or the future. I draw attention to Kant’s solutions to some of the specific problems indicated in the report. Instead of the strategy of “return of the cultural mandate”, proposed at this time by the authors of the report, the Kant­ian answer to the crisis is a “Copernican turn” and re-direction of the cultivating effort to the inner moral development of the human being.
Some Remarks about the Difference between Überzeugung and Überredung
Authors: Martinez Luciana
Published: July 2023

According to several passages in the available sources, Kant developed some ideas about the difference between being persuaded and being convinced which have antecedents in the German tradition, but with regard to which he developed ideas of his own. It is my intention to examine precisely some of these passages. I will explain how the philosopher understood this difference, what its relevance is and why the figure of the other is necessary to determine it. For this purpose, texts published in the critical period and students’ lecture notes from the same period are considered. Furthermore, I will compare the treatment of the subject in these sources and in the textbooks used by Kant in his courses. In the conclusions, the link between this issue and Kantian arguments in defending freedom of thought and expression is also suggested. In order to do so, I first explain the notion of holding to be true and its difference from the notion of being true. Secondly, I examine what it means to be convinced and what it means to be persuaded. Finally, I analyse the relevance of alterity for the identification of this difference and consider the importance of freedom of expression.
La tecnología de localización aplicada a la investigación científica: el cumplimiento normativo en torno a la protección de datos personales
Authors: Pérez Campillo Lorena
Published: July 2023

Al inicio de la pandemia surgieron múltiples aplicaciones móviles escalables con tecnología de rastreo promovidos por administraciones públicas y gobiernos con el objeto de gestionar y controlar la pandemia, generando datos personales e individuales como agregados. Los operadores de telecomunicaciones las pusieron en manos de las autoridades y organismos epidemiológicos y aunque no se compartía información personal se pudo comprobar que a través de los metadatos y la combinación de los mismos se podía obtener información personal y vulnerar los derechos fundamentales de las personas e incluso su propia seguridad. El noventa y cinco por ciento de las personas se pueden identificar fácilmente desde solo cuatro puntos de ubicación diferentes. Además, con las alianzas entre empresas tecnológicas y organizaciones farmacéuticas nace un cierto riesgo a la «mercantilización» de los datos con fines más espurios que no tendría porque coincidir con el principal interés público de la salud pública, y esto nos sitúa a la comunidad investigadora en el momento oportuno para reflexionar sobre la legitimidad del tratamiento de esos datos, los riesgos y su nivel de «anonimización» (y la más temida y advertida) «reidentificación», la cual no puede ser evitada por completo.Cuando se habla del consentimiento como base legitimadora no siempre tiene que ir «sola» sino acompañada de otras bases legitimadoras. Por ello, sería importante que se estableciera normativamente cuáles podrían componer una «base legítima doble», optando preferiblemente, por el interés público y el interés legítimo. En caso de elegir únicamente la base jurídica de interés público, debería estar formulada junto a la prueba de proporcionalidad rigurosa y garantías contra el uso indebido y acceso ilegal.En definitiva, se deberá percibir a la privacidad como un valor institucional (acorde a las políticas públicas) desde el inicio identificando el nivel de invasión recogiendo la menor cantidad de datos, evitando cualquier tipo «opacidad en la información» e implementando medidas técnicas como la anonimización y pseudonimización sin perjudicar el fin propio de la investigación.
Endoscopic retrograde cholangiopancreatography-related complications: risk stratification, prevention, and management
Authors: Wu Clement Chun Ho , Lim Samuel Jun Ming , Khor Christopher Jen Lock
Published: July 2023

Endoscopic retrograde cholangiopancreatography (ERCP) plays a crucial role in the management of pancreaticobiliary disorders. Although the ERCP technique has been refined over the past five decades, it remains one of the endoscopic procedures with the highest rate of complications. Risk factors for ERCP-related complications are broadly classified into patient-, procedure-, and operator-related risk factors. Although non-modifiable, patient-related risk factors allow for the closer monitoring and instatement of preventive measures. Post-ERCP pancreatitis is the most common complication of ERCP. Risk reduction strategies include intravenous hydration, rectal nonsteroidal anti-inflammatory drugs, and pancreatic stent placement in selected patients. Perforation is associated with significant morbidity and mortality, and prompt recognition and treatment of ERCP-related perforations are key to ensuring good clinical outcomes. Endoscopy plays an expanding role in the treatment of perforations. Specific management strategies depend on the location of the perforation and the patient’s clinical status. The risk of post-ERCP bleeding can be attenuated by preprocedural optimization and adoption of intra-procedural techniques. Endoscopic measures are the mainstay of management for post-ERCP bleeding. Escalation to angioembolization or surgery may be required for refractory bleeding. Post-ERCP cholangitis can be reduced with antibiotic prophylaxis in high risk patients. Bile culture-directed therapy plays an important role in antimicrobial treatment.
Cincuentenario Promoción Fernando Rísquez 1971
Authors:   Médico Psiquiatra, Delgado Machado Pedro
Published: July 2023

Palabras acto Academia de Medicina Gracias a las amigas que me acompañaron al Púlpito Presidente ANM Dr. Enrique López-Loyo Vicepresidenta Dra. Isis Nezer de Landaeta muy estimada docente de esta promoción, demás miembros de la ANM Dra. Cecilia García Arocha Rectora de nuestra Alma Mater UCV Invitados especiales a este acto Familiares y amigos que nos acompañan Queridos graduandos de la Promoción Fernando Rísquez Iribarren 1971 de la Escuela Luis Razetti y compañeros de la Escuela Vargas, Amigas y Amigos todos.
Palabras Pronunciadas con motivo de los 50 años de la Promoción Rodolfo Selle Escuela Vargas
Authors: Ramírez González Angel
Published: July 2023

Hemos escogido el lugar en el cual se manifiesta el testimonio de los hechos esenciales por la profesión, y en que se congregan sus representantes más eminentes, para reafirmar los fundamentos de una actividad esencial, para la sociedad en la cual hemos crecido como criaturas de la Universidad y como ciudadanos de Venezuela. Agradecemos la acogida de la Academia, desde luego, porque mejor espacio no podíamos encontrar para el reconocimiento que queremos y debemos hacer los integrantes de la promoción que escogió como epónimos a los sabios maestros y destacadas figuras de la convivencia ciudadana como fueron Félix Pífano Rodolfo Selle, en nuestra recordada y entrañable Escuela de Medicina José María Vargas de la U.C.V.
Successful Medical Management of Neurological Disease in Three Dogs Treated with Acupuncture and Chinese Herbal Medicine
Authors: Handojo Sheila , Ming Jasmine , Okarina Zita
Published: July 2023

Traditional Chinese veterinary medicine (TCVM) including acupuncture, Chinese herbal medicine, food therapy and Tui-na is focused on providing a unique group of strategies for therapy of neurological disorders. Recent studies have looked at improved treatment of neurological disease by optimizing strategies using traditional Chinese veterinary medicine versus the sole use of conventional treatments. In this case series, successful management of brain and spinal cord disease with acupuncture as the sole treatment or acupuncture and Chinese herbal medicine combined is documented in 3 dogs.
Determinants of Hand Washing with Soap (HWWS) in Rural Communities: Cross Sectional Study in Manggarai Regency East Nusa Tenggara Indonesia
Authors: Ngambut Karolus , Banne Tondok Santalia , Ata Maran Albertus , Bare Telan Albina , Rino Vanchapo Antonius , R.V Purba Ellen , Djunaedi Djunaedi
Published: July 2023

Hand Washing With Soap (HWWS) behavior is a simple thing that can be done to inhibit the transmission of disease from the source of infection. Not much is known with certainty about the determinants of community handwashing behavior as a basis for promoting handwashing behavior. The research aims to identify the various determinants of HWWS behavior in the rural community, the results of which can be considered for designing the promotion of HWWS behavior in rural community and economically vulnerable groups.

A total of 52 villages as survey locations, interviews and observations were carried out on 168 household heads who were determined by purposive random sampling with the inclusion criteria of having toddlers, and the house is on the edge of a river / beach. Univariate data processing to describe the characteristics of respondents and bivariate analysis to describe the relationship between the various HWWS behavior variables.

The results of the study showed that the majority of the community already had HWWS facilities and were around the house where they lived. Critical times for community hand washing behavior are when hands are dirty, after feeding livestock and before eating. There is no difference between the determinants of HWWS behavior with education and with household categories based on the number of repeaters. Health cadres and local health workers dominate the sources of information obtained by the community regarding HWWS behavior.

The implication of the results of this study is that the promotion of HWWS behavior in the community needs to consider non-health messages such as HWWS carried out when hands are dirty, after feeding livestock and before eating. In addition to inhibiting the spread of diseases that are transmitted through hands, the goal of HWWS behavior is also. In addition, health cadres and health workers are very important as a channel for conveying education about HWWS behavior in the community, in addition to the use of social media.
Health and Safety Risk Analysis with JSA Method (Job Safety Analysis)
Authors: Imran Ali , Nursinah Andi , B Muslimin , Kadir Erni , Rino Vanchapo Antonius , Suabey Suningsih , Hermawan Adi
Published: July 2023

Occupational safety and health in hospitals as health services is an important thing to pay attention to. Nurses as one of the medical personnel in the hospital have risks and hazards that are quite vulnerable in every process of their work. Data found from the PPI (Infection Prevention and Control) committee at DR Tadjuddin Chalid General Hospital Makassar as many as 17 cases of needle stick accidents in the last 5 years, there was 1 case of a slip/fall accident when an inpatient co-worker took the patient to the operating room. The purpose of this study is to describe the level of occupational safety and health risks that can occur in nurses at DR Tadjuddin Chalid General Hospital Makassar. The research design used is qualitative in nature with the approach method, namely risk management with interview guide instruments, observation, cameras for documentation and Job Safety Analysis to identify the risks and hazards of nurses' work. Risk assessment uses a semi-quantitative method. The results of this study indicate that the highest risk in the Emergency Room with a score of 300 (Priority 1) is at the anamnase stage and the patient's vital signs, there is a risk of danger of droplet contact contracting the patient's infectious disease and during infusion there is a risk of needle sticks. The results in the ICU show a risk level with a value of 300 (Priority 1) in the administration of injection drugs, infusion with a risk of needle pricks and in personal hygiene activities with a value of 90, there is a risk of contact with the patient's body fluids, and the results in ordinary hospitalization show a high level of risk with a value of 300 (Priority 1) on the examination of the patient's vital signs with a risk of danger of contact with the patient's body fluids, installation of infusion and administration of injection drugs, risk of needle stick hazard. The conclusion from the research results obtained is that there is a need for technical improvements, it is hoped that better supervision in the implementation of SOPs for nursing actions and the active role of K3 Hospitals in identifying deeper stages of nurse work in hospitals.
SISTEM PAKAR UNTUK MENDIAGNOSA PENYAKIT PADA ANAK-ANAK DENGAN METODE FORWARD CHAINING DI PUSKESMAS ARAS KABU
Authors: Susilawati  , Fahmi Hasanul
Published: July 2023

Typhoid is still a disease that is often suffered by people in Indonesia, especially children. But on the other hand the lack of attention from the public to this typhus disease and the lack of knowledge about the early symptoms of typhus causes the general public to be susceptible to the disease. Lack of experts to handle typhus in health centers, especially health centers located far from the city. This of course has an impact on delays in handling patients with typhoid. To overcome this problem, appropriate action is needed to diagnose typhus in these children. An expert system using the Forward Chaining method for diagnosing typhoid in children is the best solution for recognizing the symptoms of typhoid in children as early as possible, knowing the causes of the disease and how to control it. In making this system, it takes experts who are experts in the field of typhus and children to get accurate data regarding information on typhoid in children. This typhoid diagnosis expert system is designed using the web-based PHP programming language. The design of the knowledge base in this system is made dynamically to make it easier to manage data such as adding, changing and deleting data.
IMPLEMENTASI METODE K-MEANS CLUSTERING DALAM MENGKLASTERKAN BUKU PERPUSTAKAAN DI SMK NEGERI 1 PANTAI LABU
Authors: Harianja Turiami , Fahmi Hasanul
Published: July 2023

The development of the era of globalization in the field of technology at this time, or what is often referred to as the development of the technological industrial revolution, makes technology grow rapidly from time to time. One technology that shows development is a computerized system, which does not rule out the possibility that it will always be used in human activities. (Fahmi & Sianturi, 2019). The use of computers has penetrated almost all areas of human life today, such as in the field of education. Computer technology also plays an important role in helping humans to take important decisions such as making decisions in processing large data or what is now called Data Mining.The existence of books is very important, especially for students in schools at SMK Negeri 1 Pantai Labu. This research was conducted at SMK Negeri 1 Pantai Labu. However, to read and search for books in the Library of SMK Negeri 1 Pantai Labu, it is necessary to have a way to do clustering to make it easier to group books according to reading interests.
OPTIMALISASI RUTE PENGANGKUTAN SAMPAH MENGGUNAKAN METODE TRAVELLING SALESMAN PROBLEM (STUDI KASUS DINAS LINGKUNGAN HIDUP KOTA BINJAI)
Authors: Pratiwi Annisa , Syahputra Siswan , Arliana Lina
Published: July 2023

Sampah merupakan suatu permasalahan lingkungan yang tidak ada hentinya dan permasalahan dari sampah perlu dipikirkan dan ditanggulangi bersama. Rute pengangkutan sampah dari Tempat Pembuangan Sementara ke Tempat Pembuangan Akhir (TPA) selama ini masih kurang optimal karena terdapat beberapa rute dengan kendaraan yang mengangkut sampah tidak memaksimalkan kapasitas kendaraan. Penelitian ini bertujuan untuk menentukan rute optimal pengumpulan sampah di kota binjai dalam hal waktu dan biaya. Travelling Salesman Problem (TSP) digunakan untuk memodelkan masalah optimasi. Hasil analisis menunjukkan bahwa terjadi efisiensi pada waktu dan jarak pada rute yangdiusulkan sehingga menghemat 50,2 menit dan 0,9 km untuk setiap operasi layanan.
The Contribution of Regional Tax to Regional Original Income of West Nusa Tenggara Province in 2018-2022
Authors: Hak Muhamad Bai’ul , Marlina Nisa
Published: July 2023

This article analyzes the trend of regional tax contributions to Regional Original Income (PAD). The paper used descriptive quantitative approach by using secondary data. The secondary data used  over period 2018-2022. The results show that the regional Income is a component of budgeting system in one province or district. In the regional income, regional tax plays an essential role as source of regional income. The higher regional tax, the higher regional original income of west Nusa Tenggara Province. The data explained that there is a slightly increase in both target and realization of regional tax. From 2018 to 2019, the realization always over to the target. On the other hand, from 2020 to 2022, the realization always under the target. Furthermore, the proportion of regional tax contributions to regional original income (PAD) is very high. Even though there are fluctuations from 2020 to 2022, the percentage is always above 50 percent of PAD.
Transient Analysis and Low Power Consumption of Oscillator using C-mos Technology at 90 nm
Authors: Akhtar Nikhat , Vaibhav  , Tiwari R.K.
Published: July 2023

The design and analysis of an oscillator in 90 nm technology using the cadence virtuoso tool. This oscillator has less noise and power consumption. There is also evidence of oscillator periodic steady state response. The portable power supplies, such as solar cells or other devices, it is crucial that electronic devices and circuits that can work at low voltages for portable electronic applications.
POST DENTAL AND ORAL – MAXILLOFACIAL IMPLANT NEUROPATHY OF TRIGEMINAL NERVE
Authors:   Dentist and OMF Surgeon at OMF Medical Service Center, Tirana, Albania, MURATI Bashkim , MUCAJ Arben ,   Reald University College
Published: July 2023

The introduction and application of ad hoc- flap designs for accessing even deep intrabony defects has led to a significant improvement in reconstructive outcomes after the use of guided tissue regeneration (GTR, Guided Tissue Regeneration) or enamel matrix derivatives (EMD). Although the additional beneficial effects of GTR and EMD are now known, in association with open curettage alone, the improvements in surgical techniques, in particular the introduction of new papilla preservation procedures, have resulted in a progressive increase in clinical attachment gain achievable with open curettage alone. The Single Flap Approach (SFA) is a simplified surgical procedure specifically designed for the treatment of periodontal bone defects. The key principle of this procedure consists in the elevation of a single mucoperiosteal access flap (buccal or oral), preserving the integrity of the interproximal supracrustal soft tissues. The article, in addition to the the oretical research and studies to date on the advantages of this surgical technique, brings in a detailed analysis the clinical case treated by the authors, analyzing the entire procedure step by step. Scientific research and their application in clinical cases have shown that SFA allows to minimize the trauma of the interproximal soft tissues by bringing reduced recession after surgery.