bluuebunny/crossref_metadata_2025 huggingface dataset:
Suitability of Polymyxin B as a Mucosal Adjuvant for Intranasal Influenza and COVID-19 Vaccines
Authors: Yoshino Naoto , Yokoyama Takuya , Sakai Hironori , Sugiyama Ikumi , Odagiri Takashi , Kimura Masahiro , Hojo Wataru , Saino Tomoyuki , Muraki Yasushi
Published: November 2023

Polymyxin B (PMB) is an antibiotic that exhibits mucosal adjuvanticity for ovalbumin (OVA), which enhances the immune response in the mucosal compartments of mice. Frequent breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants indicate that the IgA antibody levels elicited by the mRNA vaccines in the mucosal tissues were insufficient for the prophylaxis of this infection. It remains unknown whether PMB exhibits mucosal adjuvanticity for antigens other than OVA. This study investigated the adjuvanticity of PMB for the virus proteins, hemagglutinin (HA) of influenza A virus, and the S1 subunit and S protein of SARS-CoV-2. BALB/c mice immunized either intranasally or subcutaneously with these antigens alone or in combination with PMB were examined, and the antigen-specific antibodies were quantified. PMB substantially increased the production of antigen-specific IgA antibodies in mucosal secretions and IgG antibodies in plasma, indicating its adjuvanticity for both HA and S proteins. This study also revealed that the PMB-virus antigen complex diameter is crucial for the induction of mucosal immunity. No detrimental effects were observed on the nasal mucosa or olfactory bulb. These findings highlight the potential of PMB as a safe candidate for intranasal vaccination to induce mucosal IgA antibodies for prophylaxis against mucosally transmitted infections.
Interventions to Improve Knowledge, Attitudes, and Uptake of Recommended Vaccines during Pregnancy and Postpartum: A Scoping Review
Authors: Ayouni Imen , Amponsah-Dacosta Edina , Noll Susanne , Kagina Benjamin M. , Muloiwa Rudzani
Published: November 2023

Tetanus, pertussis, influenza, and COVID-19 vaccines are recommended for the prevention of related morbidity and mortality during pregnancy and postpartum. Despite the established benefits of vaccination for prenatal and postnatal women, maternal vaccination is not universally included in routine antenatal programs, especially in low- and middle-income countries. Furthermore, the uptake of recommended vaccines among pregnant and postpartum women remains below optimum globally. This review aimed to map the evidence on interventions to improve knowledge, attitudes, and uptake of recommended vaccines among pregnant and postpartum women. We conducted a comprehensive and systematic search for relevant literature in PubMed, Scopus, Web of Science, EBSCOhost, and Google Scholar. Overall, 29 studies published between 2010 and 2023 were included in this review. The majority (n = 27) of these studies were from high-income countries. A total of 14 studies focused on the influenza vaccine, 6 on the Tdap vaccine, 8 on both influenza and Tdap vaccines, and only one study on the COVID-19 vaccine. Patient-centered interventions predominated the evidence base (66%), followed by provider-focused (7%), health system-focused (10%), and multilevel interventions (17%). Overall, the effect of these interventions on knowledge, attitudes, and uptake of maternal vaccines was variable.
Comparison of Solubilization Treatment Technologies for Phosphorus Release from Anaerobic Digestate of Livestock Manure
Authors: Lee Jae Hwa , Min Kyung Jin , An Hyo Jin , Park Ki Young
Published: November 2023

This study addresses the imminent threat of phosphorus (P) depletion, investigating anaerobically digested livestock manure as a high-concentration P alternative. To achieve this objective, Visual MINTEQ software, a general-purpose software used for chemical equilibrium modeling, was employed to simulate the alteration in P species fractions at different pH levels. The investigation further examined the variation in P release rates and electrical energy consumption across various pretreatment processes as influenced by pH levels. The results indicate a significant pH influence on P release, with enhanced efficacy under both acidic and alkaline conditions. At pH 2, total P concentration peaked at 684 mg·L−1, with 83.0% reactive P, in contrast with pH 10 conditions, which exhibited 504 mg·L−1 and 48.4%, respectively. P release increased with reaction time across all pretreatment processes. Sonication notably increased P release by 126.9%, with the highest reactive P release efficiency at 2.09 mg·L−1·Wh−1, emerging as an optimal process. Simulation results using Visual MINTEQ software indicate that the inclination for P release in alkaline conditions can be ascribed to the heightened presence of hydroxyapatite, brushite, and Ca-Fe (III)-phosphate bonds with rising pH levels. These simulation results, which are consistent with the experimental results, affirm the crucial influence of cations in determining P release on pH values.
Abatement of Nitrophenol in Aqueous Solution by HOCl and UV/HOCl Processes: Kinetics, Mechanisms, and Formation of Chlorinated Nitrogenous Byproducts
Authors: Li Xiaoci , Cai Yan , Lu Junhe , Chovelon Jean-Marc , Chen Jing , Jiang Canlan , Ji Yuefei
Published: November 2023

HOCl and UV activated HOCl (UV/HOCl) have been applied for water disinfection and abatement of organic contaminants. However, the production of toxic byproducts in the HOCl and UV/HOCl treatment should be scrutinized. This contribution comparatively investigated the elimination of 4-nitrophenol and the generation of chlorinated byproducts in HOCl and UV/HOCl treatment processes. 61.4% of 4-nitrophenol was removed by UV/HOCl in 5 min with HOCl dose of 60 μM, significantly higher than that by UV (3.3%) or HOCl alone (32.0%). Radical quenching test showed that HO• and Cl• played important roles in UV/HOCl process. 2-Chloro-4-nitrophenol and 2,6-dichloro-4-nitrophenol were generated consecutively in HOCl process; but their formation was less in the UV/HOCl process. Trichloronitromethane (TCNM) was only found in the UV/HOCl process, and its production increased with increasing HOCl dosage. Besides chlorinated products hydroxylated and dinitrated products were also identified in the UV/HOCl process. Transformation pathways involving electrophilic substitution, hydroxylation, and nitration were proposed for 4-nitrophenol transformation in the UV/HOCl process. Wastewater matrix could significantly promote the transformation of 4-nitrophenol to 2-chloro-4-nitrophenol in UV/HOCl process. Results of this study are helpful to advance the understanding of the transformation of nitrophenolic compounds and assess the formation potential of chlorinated byproducts in HOCl and UV/HOCl disinfection processes.
Comparing Effects of Tolvaptan and Instruction to Increase Water Consumption in ADPKD: Post Hoc Analysis of TEMPO 3:4
Authors: Gobburu Joga , Ivaturi Vijay , Wang Xiaofeng , Shoaf Susan E. , Jadhav Pravin , Perrone Ronald D.
Published: November 2023

Key Points

In a post hoc analysis, short-term reduction in spot urine osmolality (Uosm) was associated with decreased kidney volume growth in autosomal dominant polycystic kidney disease for both tolvaptan and instruction to increase hydration alone.

For the same spot Uosm reduction, however, the kidney volume benefit was greater with tolvaptan, possibly because of greater cumulative 24-hour Uosm suppression by tolvaptan.

Background

In addition to decreasing water excretion and increasing urinary concentration, the antidiuretic hormone vasopressin plays a role in the pathophysiology of autosomal dominant polycystic kidney disease. It has been hypothesized that by suppressing vasopressin release, drinking large amounts of water might exert therapeutic effects in autosomal dominant polycystic kidney disease similar to those of tolvaptan, an antagonist of the vasopressin type 2 receptor, but evidence is lacking. We analyzed data from tolvaptan clinical trials to evaluate relationships among water intake, urine osmolality (Uosm), and change in total kidney volume (TKV).

Methods

Analysis of the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes 3:4 clinical trial in which participants were randomized to tolvaptan or placebo and instructed to drink large amounts of water. The relationship between change in spot Uosm from baseline to week 3 and change in TKV to month 12 was assessed using linear regression modeling. Two short-term tolvaptan trials were analyzed to explore relationships between intermittent Uosm sampling and 24-hour Uosm suppression.

Results

With both tolvaptan and placebo (i.e., mandated high water intake alone), Uosm reduction at week 3 was associated with reduction in TKV growth at month 12. However, for the same decrease in spot Uosm, the corresponding reduction in TKV growth was greater for tolvaptan (e.g., a −250 mOsm/kg reduction in Uosm at week 3 was associated with a −1% change in TKV at month 12 for tolvaptan versus +4.5% for placebo). In short-term trials, similar reductions in spot or trough Uosm values were achievable with tolvaptan and high water intake, but cumulative 24-hour suppression was greater with tolvaptan.

Conclusions

This analysis supports a relationship between effects on Uosm and inhibition of disease progression by tolvaptan and high water intake alone. The findings further suggest that 24-hour Uosm measurement is superior to spot Uosm for assessing suppression of vasopressin activity by tolvaptan.
External Validation of a Novel Multimarker GFR Estimating Equation
Authors: Tio Maria Clarissa , Zhu Xiaoqian , Lirette Seth , Rule Andrew D. , Butler Kenneth , Hall Michael E. , Dossabhoy Neville R. , Mosley Thomas , Shafi Tariq
Published: November 2023

Key Points

Using multiple markers may improve GFR estimation especially in settings where creatinine and cystatin C are known to be limited.

Panel eGFR is a novel multimarker eGFR equation consisting of age, sex, cystatin C, and nuclear magnetic resonance–measured creatinine, valine, and myo-inositol.

eGFR-Cr and eGFR-Cr-CysC may underestimate measured GFR, while panel eGFR was unbiased among younger Black male individuals.

Background

Using multiple markers may improve accuracy in GFR estimation. We sought to externally validate and compare the performance of a novel multimarker eGFR (panel eGFR) equation among Black and White persons using the Genetic Epidemiology Network of Arteriopathy cohort.

Methods

We included 224 sex, race/ethnicity, and measured GFR (mGFR) category–matched persons, with GFR measured using urinary clearance of iothalamate. We calculated panel eGFR using serum creatinine, valine, myo-inositol, cystatin C, age, and sex. We compared its reliability with current eGFR equations (2021 CKD Epidemiology Collaboration creatinine [eGFR-Cr] and creatinine with cystatin C [eGFR-Cr-CysC]) using median bias, precision, and accuracy metrics. We evaluated each equation's performance in age, sex, and race subgroups.

Results

In the overall cohort, 49% were Black individuals, and mean mGFR was 79 ml/min per 1.73 m2. Panel eGFR overestimated mGFR (bias: −2.4 ml/min per 1.73 m2; 95% confidence interval [CI], −4.4 to −0.7), eGFR-Cr-CysC underestimated mGFR (bias: 4.8 ml/min per 1.73 m2; 95% CI, 2.1 to 6.7), while eGFR-Cr was unbiased (bias: 2.0 ml/min per 1.73 m2; 95% CI, −1.1 to 4.6). All equations had comparable accuracy. Among Black male individuals younger than 65 years, both eGFR-Cr (bias: 17.0 ml/min per 1.73 m2; 95% CI, 8.6 to 23.5) and eGFR-Cr-CysC (bias: 14.5 ml/min per 1.73 m2; 95% CI, 6.0 to 19.7) underestimated mGFR, whereas panel eGFR was unbiased (bias: 1.7 ml/min per 1.73 m2; 95% CI, −3.4 to 10.0). Metrics of accuracy for all eGFRs were acceptable in all subgroups except for panel eGFR in Black female individuals younger than 65 years (P30: 73.3%).

Conclusions

Panel eGFR can be used to estimate mGFR and may have utility among Black male individuals younger than 65 years where current CKD Epidemiology Collaboration equations are biased.
COVID-19 vaccine-associated adverse effects; benefits outweigh the risks?
Authors: KİBAR Büşra , ÖZDEMİR Öner
Published: November 2023

COVID-19 vaccine-associated adverse effects; benefits outweigh the risks?

COVID-19 vaccine-associated adverse effects

COVID-19 vaccines are vaccines produced with the latest technology in a very short time to get rid of this disease. These vaccines have been produced and used in millions around the world. Although some simple local side effects have been reported during and immediately after the administration of the vaccine, long-term side effects affecting various organs have recently been begun to be reported, especially with the use of mRNA vaccines. This minireview discusses the issues related to these simple and less common side effects.
Terahertz Photons Improve Cognitive Functions in Posttraumatic Stress Disorder
Authors: Yu Yun , Wu Kaijie , Yang Xiao , Long Jiangang , Chang Chao
Published: November 2023

Posttraumatic stress disorder (PTSD) is a serious psychosis leading to cognitive impairment. To restore cognitive functions for patients, the main treatments are based on medication or rehabilitation training but with limited effectiveness and strong side effects. Here, we demonstrate a new treatment approach for PTSD by using terahertz (THz) photons stimulating the hippocampal CA3 subregion. We verified that this method can nonthermally restore cognitive function in PTSD rats in vivo. After THz photon irradiation, the PTSD rats’ recognitive index improved by about 10% in a novel object recognition test, the PTSD rats’ accuracy improved by about 100% in a shuttler box test, the PTSD rats’ numbers to identify target box was about 5 times lower in a Barnes maze test, and the rate of staying in new arm increased by approximately 40% in a Y-maze test. Further experimental studies found that THz photon (34.5 THz) irradiation could improve the expression of NR2B (increased by nearly 40%) and phosphorylated NR2B (increased by about 50%). In addition, molecular dynamics simulations showed that THz photons at a frequency of 34.5 THz are mainly absorbed by the pocket of glutamate receptors rather than by glutamate molecules. Moreover, the binding between glutamate receptors and glutamate molecules was increased by THz photons. This study offers a nondrug, nonthermal approach to regulate the binding between the excitatory neurotransmitter (glutamate) and NR2B. By increasing synaptic plasticity, it effectively improves the cognitive function of animals with PTSD, providing a promising treatment strategy for NR2B-related cognitive disorders.
Ladder-like Organostannoxane: Synthesis and Crystal Structure of the Second Polymorph {[(C6H5)2Sn]2[(C6H5)2ClSn]2(μ3-O)2(μ2-OH)2}∙[DMF]2
Authors: Sarr Modou , Diop Mouhamadou Birame , Boye Mouhamadou Sembene , Diassé-Sarr Aminata , Diop Libasse , Oliver Allen G.
Published: November 2023

A ladder-like organostannoxane identified as a polymorph of bis-[chloro-(m2-hydroxo)-(m3-oxo)-tetraphenyl-di-tin] dimethylformamide solvate, {[(C6H5)2Sn]2[(C6H5)2ClSn]2(μ3-O)2(μ2-OH)2}[DMF]2 (1), has been synthesized and structurally characterized by means of single-crystal X-ray diffraction analysis. Compound 1 crystallizes in the monoclinic space group P21/c with a = 23.4137(12) Å, b = 11.2525(6) Å, c = 20.2719(11) Å, β = 100.461(2)°, V = 5252.1(5) Å3, Z = 4 and Z’ = 1. The XRD discloses that the polymorph reported in this work is the full molecule which does not crystallize about any inversion center. Complex 1 exhibits a tetranuclear organotin(IV) ladder-like structure containing two external chlorides. The tetranuclear structure is comprised of a three-rung-staircase Sn4O4 cluster which consists of a ladder of four Sn2O2 units. The central Sn2O2 core forms dihedral angles of 4.00(7)° and 1.62(8)° with its two fused four-membered rings, describing a slightly bent ladder. This folding is further noticed with the dihedral angle between the two external Sn2O2 cores of 4.65(8)°. In the structure, two types of distorted trigonal bipyramid geometry at tin centers like-arrangement are disclosed. The most Sn–O bridges bond lengths describe a static trans effect affording dissymmetrical bonds. The dimethylformamide solvate molecules form a dihedral angle of 74.5(2)° and are interlinked to the tetranuclear organotin(IV) ladder via O–H···O hydrogen bond patterns. Additional inner C–H···Cl and C–H···O hydrogen bonds as well the C–H···O interactions are present. Moreover, the intermolecular C–H···O hydrogen bonds do not contribute to direct the crystal structure framework; they do not play an important function in forming a supramolecular architecture.
RECONSTRUCTION OF PERFORMANCES BASED ON PLAYS BY A.N. OSTROVSKY IN A.A. GRIGORIEV’S THEATER CRITICISM
Authors: Azeeva Irina V.
Published: November 2023

The article describes the formation of the technique of reconstruction of an on-stage performance in the theater criticism by A.A. Grigoriev. The author analyzes a well-known text on theater criticism, which has “Poverty is No Vice” by A.N. Ostrovsky, a play staged in the Alexandrinsky Theater in the early 1860s, as the subject of Grigoriev’s attention. The analysis reveals the emergence of the “theater centered” approach in the 19th century Russian theater criticism: A.A. Grigoriev is one of the first to masterfully analyze the stage texts (performances), based on A.N. Ostrovsky’s plays. The critic pays tribute to A.N. Ostrovskiy’s skill of a playwright, and places the actor’s art, which occupied an important place in the national theater of the mid-19th century, in the center of his attention. The author of the article considers a number of reconstructions of the actor’s work in the play “Poverty is No Vice” made by A.A. Grigoriev. The description of the actors’ work in the roles they perform allows the critic to be evident in his sharp judgments about their professional skill. The comparison of the reconstructions of the actors’ works by P.M. Sadovsky Sr. (Maly Theater, 1854) and P.V. Vasilyev (Alexandrinsky Theater, 1863) as Lubim Tortsov enables seeing the skill advance of a theater critic describing an actor’s art. The article also focuses on the role of reconstructing an on-going play in the process of training a theater critic in a modern theater school.
ABOUT NON-RANDOM CHANCE IN THE COMEDY OF A.N. OSTROVSKY ‟TRUTH IS GOOD, BUT HAPPINESS IS BETTER”
Authors: Kapustin Nikolay V.
Published: November 2023

With external simplicity Ostrovsky’s dramaturgy conceals the possibility of different interpretations. In this case we mean not free readings (which is especially characteristic of many modern directors), but those that are able to discover potential meanings that characterize the author’s vision of the world and man. One of these works is the comedy ‟Truth is good, but happiness is better” (1876). In the center of the article is a happy denouement of this comedy, which is an expression of the foundations of Ostrovsky’s worldview, his trust in life. The basis of the denouement is the case. It is closely correlated with the motif of apples that runs throughout the comedy and the most important comparison in the structure of the play is the one of a marriageable girl, who Polyxena is, with a juicy, ripe apple. The origins of the semantics of the apple image are usually associated with fairy tales, but the parallel with the proverb ‟The apple tree does not bloom all year round” is more precise. Its essence is to confirm natural life principles, as in Ostrovsky. At the same time, the natural principle is inseparably connected with the providential principle. All this allows us to say that the accidental denouement of the comedy is not accidental. It is the result of human aspirations, guided by natural and providential principles.
ONLY FOUR LETTERS: ABOUT THE CORRESPONDENCE OF L.N. TOLSTOY AND A.N. OSTROVSKY IN THE HISTORY OF THE RELATIONSHIP BETWEEN TWO WRITERS
Authors: Andreeva Valeria G.
Published: November 2023

The article provides an analytical understanding of Tolstoy’s letters to Ostrovsky, consideration of their content in the projection of reviews and literary disputes of the late 1850s–1860s. A scientific commentary is given on individual facts, events and opinions in Tolstoy’s letters to Ostrovsky, the problem of the ambiguous attitude of writers to each other’s work, their interaction while working in the Sovremennik magazine is touched upon. The role of Nekrasov in establishing creative ties between the writer and the playwright is noted, the individual features and characteristics that they valued and critically perceived in each other are emphasized. The author of the article cites the opinions of contemporaries who noted similarities in the work of famous contemporaries. The paper notes the possible influence of Ostrovsky on the late Tolstoy, the latter’s recognition of the nationwide significance of Ostrovsky’s talent.
‟WHAT KIND OF PEOPLE! WHAT A LANGUAGE!..” RUSSIAN CRITICISM OF THE SECOND HALF OF THE 19TH CENTURY ON THE BOUNDARIES OF ‟ETHICAL” AND ‟DECENT” IN THE DRAMATURGY OF A.N. OSTROVSKY
Authors: Belyakova Elena N.
Published: November 2023

The article highlights the problem of moral and aesthetic evaluation of the works of A.N. Ostrovsky in literary criticism of Russia in the second half of the 19th century. On the material of newspaper and magazine reviews published in the 1850s–70s, contradictions are revealed between the ethical and aesthetic expectations of the reading audience and the artistic innovations of A.N. Ostrovsky in depicting scenes of everyday reality. The article attempts to generalize critical judgments of moral and aesthetic nature, outline the range of issues and claims against the author, and track their influence on the playwright’s work.
Agronegocio y crisis hídrica en la cuenca del río Paraná
Authors: Álvarez Álvaro
Published: November 2023

En las últimas tres décadas se dio un proceso de expansión persistente del agronegocio y los monocultivos sobre la cuenca del río Paraná. Dicha expansión obedeció a un aumento de la demanda internacional de commodities lo que impulsó la denominada pampeanización del noreste argentino. Este fenómeno trajo aparejados dos procesos entrelazados: la construcción de una hidrovía sobre el río Paraná que permite la circulación y exportación de la producción agraria desde los principales puertos, y la expansión de los monocultivos sobre bosques nativos y humedales. La triada: agronegocios, deforestación e hidrovía, constituyen las dimensiones más importantes de análisis en esta investigación, que desde una mirada sistémica y compleja busca poner en contexto la crisis hídrica que atraviesa la región en general, y la bajante extrema del río Paraná en particular, para desentramar sus principales causas.
FAKTOR PENENTU PENGGUNAAN LAYANAN E-FILING PAJAK
Authors: Puspitaningrum Talia Endah , Mindarti Ceacilia Sri
Published: November 2023

Penelitian ini bertujuan untuk menguji faktor-faktor yang mempengaruhi penggunaan e-filing pajak. Populasi yang menjadi objek penelitian adalah wajib pajak orang pribadi di kota Pati. Responden yang diambil untuk penelitian sebanyak 318 wajib pajak orang pribadi. Teknik pengumpulan data dalam penelitian ini menggunakan kuesioner. Statistical Package for the Social Science (SPSS) versi 26 digunakan untuk membantu proses analisis data dalam penelitian ini. Kesimpulan penelitian ini adalah keamanan dan privasi tidak berpengaruh terhadap penggunaan e-filing, persepsi kepuasan berpengaruh positif dan signifikan terhadap penggunaan e-filing, pengalaman berpengaruh positif dan signifikan terhadap penggunaan e-filing. pengarsipan, dan pengetahuan berpengaruh positif dan signifikan terhadap penggunaan e-filing.
Structural characteristic of the model of early detection and primary pre-vention of cerebral stroke among the adult population
Authors: Mishchenko M.M.
Published: November 2023

In the article, based on the analysis of world literary sources, official statistical data, and the work of international medical organizations, a systematic analysis and generalization of modern world experience regarding the possibilities of improving the system of early detection and primary prevention of brain strokes among the adult population was carried out. Based on this, an optimized model of early detection and primary prevention of brain strokes among the adult population was developed and scientifically substantiated. The optimized model takes into account the existing medical and social problems of people with brain strokes, the existing shortcomings in the measures of early detection and primary prevention of brain strokes among the adult population, and global achievements and developments. The proposed optimized model of early detection and primary prevention of brain strokes was developed on the basis of own research, careful and thorough study and analysis of modern models of work of domestic health care institutions and best practices of other countries. The optimized model consists of six main interconnected and interdependent main activity apparatuses (structural components of the model): conceptual and categorical apparatus (purpose, tasks, principles, priorities, approaches, properties); strategic and operational apparatus (management levels: strategic, tactical, operational); rule-making apparatus (existing legal framework, formation of new rule-making acts); information and communication apparatus (collection and processing of information, formation of a data bank); functional and organizational apparatus (individual, family, group and population level); practical-implementation apparatus (resource-action and subject-object guidelines, achievement of expected results, verification of effective and corrective measures (if necessary)).

Keywords: measures of early detection and primary prevention, stroke pathology, optimized model, functional devices.
El huerto ecológico en permacultura: una alternativa sostenible
Authors: García Vera Julia , Rivero García Ana , Guerrero Fernández Alicia , García Díaz José Eduardo , Rodríguez Marín Fátima , García López Álvaro
Published: November 2023

La problemática ambiental en la que nos encontramos actualmente está causada por diversos problemas como el cambio climático, el agotamiento de los recursos naturales y la acumulación de desechos, destacándose la alimentación actual como uno de los elementos con mayor impacto en el medio ambiente. De ahí que la “alimentación sostenible” sea una temática de especial interés.

Para enseñar sobre alimentación sostenible, un recurso especialmente relevante son los huertos escolares, y dentro de ellos, los huertos ecológicos que se desarrollan en permacultura. Este audiovisual pretende dar visibilidad a este tipo de huertos como alternativa sostenible a la crisis socioambiental existente, ya que visibiliza el metabolismo social circular.

La alimentación es una de las actividades humanas que más impacto socioambiental tiene y debemos ser conscientes de ello.
Por esta razón, es idóneo explicar en términos sencillos los aspectos clave de un tipo de cultivo ecológico que minimiza el impacto, denominado permacultura, de manera que los centros educativos interesados puedan conocer cómo poner en marcha un huerto escolar de estas características. La permacultura es una corriente que promueve no solo una alternativa para la agricultura ecológica, sino que también se trata de una manera de planificar la tierra y una forma de vida más sostenible, considerando todas las posibilidades de cómo vivir en paz como humanos, guardando respeto a la tierra y a sus recursos limitados.
Las prácticas propias de un huerto ecológico en permacultura integran aspectos como:
o Un diseño integral del espacio, que permita hacer la circulación de materiales y flujo energético, minimizando la producción de residuos.
o La relevancia del ecosistema-suelo y de las técnicas para su mantenimiento.
o La forma de crear un bancal agrícola “permanente”, con un “acolchado” que crea un microclima adecuado para los cultivos, reduciendo el consumo de agua y evitando la aparición de “malas hierbas”.
o Las técnicas de distribución de las plantas y de rotación de cultivos, basadas en las asociaciones y compatibilidades entre ellas, para aumentar la producción disminuyendo los recursos necesarios.
o La superposición de árboles alrededor del bancal, para evitar la desecación producida por el viento.
o La creación de “composteros”, donde se introduzca toda la materia orgánica producida por el huerto y se devuelva a la tierra en compost, promoviendo el reciclaje de la materia, un metabolismo circular en el huerto.
o La aparición de balsas de decantación para recoger la tierra que es arrastrada por la lluvia y volverla a utilizar.
ANALISIS KEPATUHAN PERPAJAKAN BENDAHARAWAN PEMERINTAH DI DINAS PARIWISATA DAERAH PROVINSI SULAWESI UTARA
Authors: Pangkey Maria , Warongan Jessy D. L. , Wangkar Anneke
Published: November 2023

Pajak mempunyai peranan yang sangat penting dalam kehidupan bernegara, khususnya di dalam pelaksanaan pembangunan. Salah satu upaya dalam meningkatkan kepatuhan Wajib Pajak adalah memberikan pelayanan yang baik kepada Wajib Pajak. Peningkatan kualitas dan kuantitas pelayanan diharapkan dapat meningkatkan kepuasan kepada Wajib Pajak sebagai pelanggan sehingga meningkatkan kepatuhan dalam bidang perpajakan. Penelitian ini bertujuan untuk mengetahui bagaimana kepatuhan perpajakan Bendaharawan Pemerintah di Dinas Pariwisata Daerah Provinsi Sulawesi Utara. Penelitian ini menggunakan pendekatan kualitatif dengan metode analisis deskriptif. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu wawancara dan dokumentasi. Analisis data yang dilakukan dalam penelitian ini yaitu dengan mengumpulkan data, mereduksi data, menyajikan data kemudian menarik kesimpulan. Hasil penelitian ini menunjukkan bahwa Bendaharawan Pemerintah pada Dinas Pariwisata telah patuh dalam menjalankan kewajibannya sebagai wajib pajak pihak ketiga dalam menyetorkan pajak terutang, melaporkan pajak, menghitung pajak terutang dan memotong maupun memungut pajak.
 
Kata Kunci: kepatuhan perpajakan
THE EFFECT OF JOB SATISFACTION, ORGANIZATIONAL COMMITMENT, AND WORK ENVIRONMENT ON TURNOVER INTENTION AT PT. HASJRAT ABADI SUDIRMAN
Authors: Bagau Ephifania Sartje Louisa , Kindangen Paulus , Tumewu Ferdinand J.
Published: November 2023

The purpose of this study was to know the effect of job satisfaction, organizational commitment, and work environment on turnover intention at PT. Hasjrat Abadi Sudirman. This study uses a population as a sample, where the total number of respondents is 86 employees. This research was carried out using quantitative methods and data collection techniques by distributing questionnaires. The research results show that job satisfaction has a significant negative effect on turnover intention, organizational commitment has a significant negative effect on turnover intention, while the work environment has no effect on turnover intention. Simultaneously job satisfaction, organizational commitment, and work environment have an influence on employee turnover intention at PT. Hasjrat Abadi Sudirman.
 
Keyword: turnover intention, job satisfaction, organizational commitment, work environment
ANALISIS PENGENDALIAN PERSEDIAAN BAHAN BAKU TEPUNG PADA TOKO ROTI ACONG MENGGUNAKAN ECONOMIC ORDER QUANTITY
Authors: Masengi Titania , Palandeng Indrie Debbie
Published: November 2023

Penelitian ini bertujuan untuk lebih mengetahui bagaimana pengendalian persediaan bahan baku tepung yang optimal pada Toko Roti Acong. Dengan melakukan perbandingan antara metode konvensional yang perusahaan gunakan dan metode Economic Order Quantity (EOQ). Penelitian ini merupakan jenis penelitian kualitatif dengan metode pengumpulan data yang diambil berupa, data primer yaitu pengumpulan data dengan melakukan wawancara dengan owner toko atau karyawan toko dan melakukan observasi dan melihat aktifitas yang ada di toko. Dan juga data sekunder yaitu dengan melihat data persediaaan bahan baku pada Toko Roti dan hasil produksi yang ada. Dari hasil penelitian dapat dikatakan bahwa dalam Toko Roti Acong belum optimal dalam pengendalian persediaan bahan baku tepungnya. Dalam melakukan pemesanan, perusahaan hanya berdasarkan perkiraan mereka saja dan belum menggunakan metode apapun dalam kebijakan pengendalian persediaan bahan baku. Sehingga hasil penelitian menunjukan bahwa Toko Roti Acong dalam pengendalian persediaan bahan baku tepung masih menggunakan metode konvensional atau berdasarkan perkiraan saja, sehingga membuat pengendalian persediaan bahan baku tepung belum optimal dan mengakibatkan naik lumayan tinggi total biaya persedian. Kuantitas pemesanan bahan baku tepung menurut metode Economic Order Quantity (EOQ) jauh lebih besar dari pada kebijakan yang diterapkan oleh Toko Roti Acong, walaupun biaya yang dikeluarkan dapat di minimalkan. Oleh karena itu dapat disimpulkan bahwa Metode EOQ sangat efektif bagi perusahaan dalam mengendalikan persediaan bahan baku terutama untuk menghemat biaya.
Kata Kunci: Pengendalian, Persediaan, Pengendalian Persedian, Pengendalian Persediaan Bahan Baku, Economic Order Quantity.
EVALUASI PENCATATAN DAN PELAPORAN ANGGARAN BELANJA BERDASARKAN PERMENDAGRI NO 84 TAHUN 2022 PADA DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL JAILOLO
Authors: Umasangaji Weni Astia K , Morasa Jenny , Sardjono Olivia Y.M
Published: November 2023

Penelitian ini dilakukan pada Dinas Kependudukan dan Pencatatan Sipil Jailolo dengan memiliki tujuan mengevaluasi apakah pencatatan dan pelaporan anggaran belanja pada Dinas Kependudukan dan Pencatatan Sipil Jailolo telah sesuai dengan Permendagri No 84 Tahun 2022. Terkait dengan menganalisis jenis data penelitian ini menggunakan metode kualitatif deskriptif. Hasil penelitian menunjukkan pencatatan dan pelaporan atas anggaran belanja pada Dinas Kependudukan dan Pencatatan Sipil Jailolo telah sesuai dengan Permendagri No 84 Tahun 2022 tentang Pedoman Penyusunan Anggaran Belanja Daerah, dengan ditunjukkan prosedur pencatatan anggaran belanja yang dicatat oleh bendahara pengeluaran dan bendahara pengeluaran pembantu menggunakan buku kas umum, buku pembantu bank,buku pembantu kas tunai melalui SIPD dan SIMDA-NG (FMIS) dan pelaporan mengenai dokumen pelaporan anggaran belanja yang dilakukan secara rutin oleh bendahara pengeluaran dan bendahara pengeluaran pembantu serta bukti pelaporan belanja dengan masing-masing klasifikasi kode rekening akun belanja yang telah sesuai mengikuti pedoman Permendagri No 84 Tahun 2022.
 
Kata Kunci: Pencatatan, Pelaporan, Anggaran Belanja.
Electromagnetically induced transparency based on spoof localized surface plasmons
Authors: Tong Jinye , Wang Yi , Xu Zhixia
Published: November 2023

A pair of resonators are used to realize multiple electromagnetically induced transparency-like (EIT-like) transmission peaks operating in the microwave band, with the bright and dark modes being symmetric double-ellipsoids and spoof localized surface plasmons. The simulation and test results reveal that the EIT-like metamaterial may generate three transparent EIT-like transmission peaks in the 9~12 GHz frequency range. Following that, we propose a plasmonically induced transparency refractive index sensor that operates in the IR range. The group delay in this sensor has broad applicability in diverse surface sensing based on EIT-like metamaterials.
Faktor yang Mempengaruhi Minat Beli Produk Makanan dan Minuman Usaha Kecil Menengah di Pekanbaru
Authors: Syafitri Intan , Syaefulloh Syaefulloh
Published: November 2023

Penelitian ini bertujuan untuk melihat bagaimana bentuk pengaruh dari kualitas produk, layanan yang dirasakan oleh konsumen, serta harga terhadap minat beli produk-produk UKM di Pekanbaru. Jenis penelitian ini adalah Kuantitatif. Objek penelitian atau yang di teliti yaitu Usaha Kecil dan Menengah (UKM) di Pekanbaru. Subjek penelitian ini adalah konsumen-konsumen produk UKM. Metode pengumpulan data pada penelitian ini melalui Personally Administered Questionnaires atau kusioner yang di kelola pribadi yang di isi oleh 100 responden. Metode analisis nya menggunakan regresi berganda. Secara simultan, kualitas produk, layanan yang dirasakan dan harga berpengaruh terhadap minat beli. Secara keseluruhan, kualitas produk dan harga sangat berpengaruh pada minat beli.
Biological properties of nanomaterials (literature review)
Authors: Paliy A. P. , Kovalenko L. V. , Romanko M. Ye. , Stegniy M. Yu. , Kolchyk O. V. , Zavgorodniy A. I. , Kornieikov O. M.
Published: November 2023

In the article reviewed and discussed literature data on biological properties of nanomaterials. The biosafety of nanomaterials is a complex and multifaceted issue that demands a comprehensive, science-based approach. Modern environmental and economic factors should be considered in this regard. The EU’s nanotechnology policy is based on ‘an integrated, safe and responsible approach’ (Communication from the Commission to the European Parliament, the Council and the European Economic and Social Committee. Regulatory aspects of nanomaterials. SEC(2008) 2036 / COM(2008) 366 final). Based on the findings of toxicity and antimicrobial activity studies, metal nanoparticles appear to be a favorable choice as antibacterial agents in developing new disinfectants. However, further measures must be taken to ensure the safe and environmentally friendly use of metal nanoparticles (MeNPs). To achieve this, it is crucial to establish toxicity parameters for MeNPs of various compositions, sizes, and concentrations. These parameters must be compared and evaluated alongside the potential effects of MeNPs on laboratory and target animals (in vivo), as well as their antibacterial performance against microorganisms of different strains (in vitro). Thus, the investigation of possible hazards associated with the use of metal nanoparticles can be effectively achieved by analyzing the fundamental systemic characteristics of biological systems under both in vivo and in vitro conditions, taking into account various aspects such as physiological, biochemical, immunological, genetic and cytological responses that may be affected by toxic effects. The literary sources analysis and article publication were conducted under the National Research Foundation of Ukraine project No. 2021.01/0076 'Development of a novel, nanoparticle-based disinfectant for deactivation of pathogens causing emergent infectious diseases'
Risk of Swine influenza for veterinary medicine and human health in Ukraine
Authors: Stegniy B. T. , Rula O. M. , Muzyka N. M. , Dunaiev Yu. K. , Busol V. O. , Kolchyk O. V. , Muzyka D. V.
Published: November 2023

The article provides a brief review of the literature on influenza viruses, including their prevalence, classification, pathogenicity, ability to mutate and reassort, and some peculiarities of their biological properties. Special attention is given to swine influenza, since interspecies transmission of influenza viruses between pigs and humans can have serious consequences for both human and veterinary medicine. The results of pilot studies conducted at the NSC ‘IECVM’ prove the circulation of influenza A viruses among pigs in Ukraine — 324 samples of blood sera from pigs of different age groups from different regions of Ukraine were tested using an ELISA test system, 48 (14.8%) positive samples were found. Seroprevalence reached 100% in some farms and antibodies were detected in animals aged 24–73 days. The prospect of further work is to conduct surveillance studies (serological, molecular biological, virological) of pigs in both large breeding complexes and private households to detect antibodies to influenza A and, based on the results obtained, to draw conclusions about the circulation of influenza A viruses in Ukraine
Some Anthropometric and Sociodemographic Parameters of School Age Respondents (10-20) Years in Garun Mallam, Kano State, Nigeria
Authors:   Department of Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria., Murdakai Tanko , I.U. Usman ,   Department of Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria., AA Sadeeq ,   Department of Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria., AA Ominiyi ,   Department of Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria., AI Mukthar ,   Department of Anatomy, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria.
Published: November 2023

ABSTRACT Background: Anthropometric characteristics vary from one ethnic group to another. The study was carried out to assess the anthropometric and sociodemographic characteristics of School-aged children and adolescents (10-20 years of age) in Garun Mallam Local Government Area, Kano State. Methodology: Four hundred subjects made up of 299 males and 101 females were recruited for this research. The anthropometric variables measured were height, weight, body mass index, head and neck circumferences, hand length, hand breadth, foot length, and foot breadth as well as some sociodemographic characteristics. All measurements were taken according to standard protocols. One-way Analysis of variance was used for the comparison of the parametric data among the four groups of independent categories and the Kruskal Wallis test was used for non-parametric data among two groups of independent categories. Pearson correlation was used to test for the correlation of all the measured anthropometry parameters. Data were analyzed using SPSS Version 17 and P<0.05. Results: Sexual dimorphism in the anthropometric variables such as height, weight, hand anthropometry, and foot anthropometry. There was no significant difference observed between the Igbos and Yoruba in both sexes (p>0.05). Hausas were relatively shorter in both sexes and all the measured anthropometry parameters had a strong positive correlation with each other. Conclusion: The study has documented some of the anthropometric parameters of School children and sociodemographic characteristics of the parents of children and adolescents of Garun Mallam Local Government of Kano State which can serve as baseline data.
Kawasaki Disease Associated with Streptococcal Infection and Facial Nerve Palsy: A Case Report
Authors:   Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika – Zaria, Musa Abdullahi , A. Olorukooba Abiola ,   Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika – Zaria, M. Abdullahi Sakinatu ,   Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika – Zaria, Musa Sani ,   Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika – Zaria, U. Makarfi Hauwa ,   Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Shika – Zaria
Published: November 2023

ABSTRACT Background: Kawasaki disease (mucocutaneous lymph node syndrome), an acute febrile vasculitis of childhood that affects medium and small-sized arteries, is uncommonly reported in the West African sub-region. Its diagnosis relies on the presence of a constellation of clinical signs which could mimic or coexist with infectious viral or bacterial agents, thereby requiring a high index of suspicion. Case presentation: We report a two-year, ten months-old boy who presented with prolonged high-grade fever for over 3 three weeks; non-purulent conjunctivitis, unilateral cervical lymphadenopathy, cracked lips, reddish tongue, diffuse oedema, erythema of his palms and soles; skin desquamation over the tips of his digits and left-sided facial nerve palsy. He had leukocytosis, thrombocytopenia, and elevated inflammatory markers. Throat swab yielded Streptococcus pyogenes species; however, serial echocardiography was unrevealing. He was managed with aspirin, steroids, bed rest, and antibiotics (based on culture sensitivity), but intravenous immunoglobulin (IVIG) was not readily available and therefore was not administered. His inpatient clinical course showed fever persisting into the second week of inpatient management that gradually became undulating by the third week before lysing. Conclusion: The rare complication of facial nerve palsy is highlighted, while the evidence for acute bacterial infection posed further diagnostic challenges in this child with clinical features of Kawasaki disease. The unavailability of IVIG also portends a prolonged course for the acute stages, which are largely unresponsive to antipyretics and antibiotics. The importance of long-term follow-up for potential coronary artery aneurysms in the face of risk factors is further emphasized.
A importância da ética aristotélica na educação ambiental para a promoção do desenvolvimento sustentável e o alcance da felicidade
Authors: BRAGA MAURO AUGUSTO PONCE DE LEÃO , VEIGA SASHA CAMILO SUANO D’ALBUQUERQUE , MATTA VANESSA MAIA DE QUEIROZ
Published: November 2023

O presente artigo busca dar ênfase à importância da ética na educação ambiental para a promoção do desenvolvimento sustentável e o alcance da felicidade. Nesse aspecto, segundo a ética aristotélica, a virtude é a excelência do caráter e o bem supremo da vida é a felicidade. Apesar disso, com a ideia de que o ser humano e a natureza são organismos dissociados, o antropocentrismo intensificou a exploração dos recursos naturais, levando a humanidade a uma crise ambiental e social, marcada pela falta de ética, de equilíbrio e de solidariedade. Diante desse contexto, a temática voltou a ser objeto de políticas e normas estrangeiras e pátrias para implementar uma educação voltada a preservar o meio ambiente e estabelecer uma relação de mútua cooperação entre homem e natureza. Nesse esteio, a ética contribui para o alcance da sustentabilidade, da solidariedade e do desenvolvimento sustentável, permitindo o desenvolvimento econômico, sem prejuízo da proteção social e ambiental. Assim, a educação ambiental apresenta-se como instrumento para ensino da ética e, desta feita, como mecanismo para alcance do desenvolvimento sustentável, o qual, por seu turno, serve de ferramenta para alcance da felicidade.
Development of Decision Support System (DSS) for Greenhouse Ventilation and Cooling Control
Authors: Jamaludin Diyana , Mohd Shukri Aini Amini , M Kassim M Saufi , Hamzah Muhammad Hazwan
Published: November 2023

The confined heat created by the sunlight and ambient temperature is one of the obstacles to greenhouses in the tropics. A conservatory in tropical regions thus requires a proper ventilation and cooling system to provide an ideal greenhouse temperature to support crop production. The main objective of this study is to develop a Decision Support System (DSS) for optimum greenhouse ventilation and cooling control. An equation model to predict the temperature inside was developed by considering heat generation and heat loss inside the greenhouse. The accuracy of the equation model was validated with secondary data from the on-field greenhouse by statistical evaluation metrics. The statistical evaluation proved that the equation model is good with 2.11°C of Root Mean Square Error (RMSE), 6.22% of Percent BIAS (PBIAS) and 0.94 of Nash-Sutcliffe efficiency (NSE) value. A DSS using Microsoft Excel with Visual Basic for Applications (VBA) is developed based on the equation model to provide the ventilation and cooling system information. Input required for the DSS is a climatic condition, dimension and covering greenhouse material. The output of the DSS is the temperature inside the greenhouse, natural ventilation design, forced ventilation, active cooling system design using an evaporative pad and fan, and fogging system. The DSS can be used as an approach for ventilation and cooling design recommendation for the optimum temperature inside the greenhouse.