bluuebunny/crossref_metadata_2025 huggingface dataset:
Melanoma Brain Metastases: A Retrospective Analysis of Prognostic Factors and Efficacy of Multimodal Therapies
Authors: Internò Valeria , Sergi Maria Chiara , Metta Maria Elvira , Guida Michele , Trerotoli Paolo , Strippoli Sabino , Circelli Salvatore , Porta Camillo , Tucci Marco
Published: March 2023

Brain metastasis in cutaneous melanoma (CM) has historically been considered to be a dismal prognostic feature, although recent evidence has highlighted the intracranial activity of combined immunotherapy (IT). Herein, we completed a retrospective study to investigate the impact of clinical–pathological features and multimodal therapies on the overall survival (OS) of CM patients with brain metastases. A total of 105 patients were evaluated. Nearly half of the patients developed neurological symptoms leading to a negative prognosis (p = 0.0374). Both symptomatic and asymptomatic patients benefited from encephalic radiotherapy (eRT) (p = 0.0234 and p = 0.011). Lactate dehydrogenase (LDH) levels two times higher than the upper limit normal (ULN) at the time of brain metastasis onset was associated with poor prognosis (p = 0.0452) and identified those patients who did not benefit from eRT. Additionally, the poor prognostic role of LDH levels was confirmed in patients treated with targeted therapy (TT) (p = 0.0015) concerning those who received immunotherapy (IT) (p = 0.16). Based on these results, LDH levels higher than two times the ULN at the time of the encephalic progression identify those patients with a poor prognosis who did not benefit from eRT. The negative prognostic role of LDH levels on eRT observed in our study will require prospective evaluations.
Macrophage Biomarkers sCD163 and sSIRPα in Serum Predict Mortality in Sarcoma Patients
Authors: Aggerholm-Pedersen Ninna , Friis Henriette Nymark , Baad-Hansen Thomas , Møller Holger Jon , Sandfeld-Paulsen Birgitte
Published: March 2023

Most soft tissue sarcoma (STS) patients do not respond to traditional checkpoint inhibitor treatment, which may be due to infiltrating immunosuppressive tumour-associated macrophages. This study investigated the prognostic value of four serum macrophage biomarkers. Methods: Blood samples were taken from 152 patients with STS at the time of diagnosis; clinical data were prospectively collected. The concentrations of four macrophage biomarkers (sCD163, sCD206, sSIRPα, sLILRB1) were measured in serum, dichotomised based on median concentration, and evaluated either individually or when combined with established prognostic markers. Results: All macrophage biomarkers were prognostic of overall survival (OS). However, only sCD163 and sSIRPα were prognostic for recurrent disease (sCD163: hazard ratio (HR): 1.97 (95% CI: 1.10–3.51) and sSIRPα: HR: 2.09 (95% CI: 1.16–3.77)). A prognostic profile was made based on sCD163 and sSIRPα; it also included c-reactive protein and tumour grade. Patients with intermediate- or high-risk prognostic profiles (adjusted for age and tumour size) had a higher risk of recurrent disease compared to low-risk patients (HR: 2.64 (95% CI: 0.97–7.19)) and (HR 4.3 (95% CI: 1.62–11.47)), respectively. Conclusion: This study demonstrated that serum biomarkers of immunosuppressive macrophages were prognostic for OS; when combined with well-established markers of recurrence they allowed for a clinically relevant categorising of patients.
The Reptile Relocation Industry in Australia: Perspectives from Operators
Authors: Derez Chantelle M. , Fuller Richard A.
Published: March 2023

Thousands of reptiles are relocated annually in Australia, yet there has been relatively little research aimed at understanding how the reptile relocation industry operates. An online questionnaire was distributed to anyone who had relocated a reptile between April 2019 and April 2020, including wildlife relocators, wildlife rehabilitators and the general public. The questionnaire explored demographics, decision-making and concerns about how the industry functions, through 24 questions and two opportunities to provide open-ended comments. We received 125 responses and 123 comments from operators in all Australian states and territories. Beliefs about appropriate times and places for reptile releases were not reflected in practice for the majority of operators. Confidence about reptiles remaining at recipient sites was low regardless of how many years’ experience an operator had. Escaped captive native reptiles were encountered by most operators, and a quarter of operators were called out to exotic non-native snakes. Operators across all levels of experience indicated a need for changes within the industry, including increased training and professionalism, and more scientific studies on the outcomes of relocations to address concerns about the impacts that the industry has on the wildlife that it is trying to protect.
Fate Decisions of Chicken Primordial Germ Cells (PGCs): Development, Integrity, Sex Determination, and Self-Renewal Mechanisms
Authors: Ichikawa Kennosuke , Horiuchi Hiroyuki
Published: March 2023

Primordial germ cells (PGCs) are precursor cells of sperm and eggs. The fate decisions of chicken PGCs in terms of their development, integrity, and sex determination have unique features, thereby providing insights into evolutionary developmental biology. Additionally, fate decisions in the context of a self-renewal mechanism have been applied to establish culture protocols for chicken PGCs, enabling the production of genome-edited chickens and the conservation of genetic resources. Thus, studies on the fate decisions of chicken PGCs have significantly contributed to both academic and industrial development. Furthermore, studies on fate decisions have rapidly advanced owing to the recent development of essential research technologies, such as genome editing and RNA sequencing. Here, we reviewed the status of fate decisions of chicken PGCs and provided insight into other important research issues that require attention.
Review of Recurrently Mutated Genes in Craniosynostosis Supports Expansion of Diagnostic Gene Panels
Authors: Tooze Rebecca S. , Calpena Eduardo , Weber Astrid , Wilson Louise C. , Twigg Stephen R. F. , Wilkie Andrew O. M.
Published: March 2023

Craniosynostosis, the premature fusion of the cranial sutures, affects ~1 in 2000 children. Although many patients with a genetically determined cause harbor a variant in one of just seven genes or have a chromosomal abnormality, over 60 genes are known to be recurrently mutated, thus comprising a long tail of rarer diagnoses. Genome sequencing for the diagnosis of rare diseases is increasingly used in clinical settings, but analysis of the data is labor intensive and involves a trade-off between achieving high sensitivity or high precision. PanelApp, a crowd-sourced disease-focused set of gene panels, was designed to enable prioritization of variants in known disease genes for a given pathology, allowing enhanced identification of true-positives. For heterogeneous disorders like craniosynostosis, these panels must be regularly updated to ensure that diagnoses are not being missed. We provide a systematic review of genetic literature on craniosynostosis over the last 5 years, including additional results from resequencing a 42-gene panel in 617 affected individuals. We identify 16 genes (representing a 25% uplift) that should be added to the list of bona fide craniosynostosis disease genes and discuss the insights that these new genes provide into pathophysiological mechanisms of craniosynostosis.
TERRA and Telomere Maintenance in the Yeast Saccharomyces cerevisiae
Authors: Zeinoun Bechara , Teixeira Maria Teresa , Barascu Aurélia
Published: March 2023

Telomeres are structures made of DNA, proteins and RNA found at the ends of eukaryotic linear chromosomes. These dynamic nucleoprotein structures protect chromosomal tips from end-to-end fusions, degradation, activation of damage checkpoints and erroneous DNA repair events. Telomeres were thought to be transcriptionally silent regions because of their constitutive heterochromatin signature until telomeric long non-coding RNAs (LncRNAs) were discovered. One of them, TERRA (TElomeric Repeat-containing RNA), starts in the subtelomeric regions towards the chromosome ends from different telomeres and has been extensively studied in many evolutionarily distant eukaryotes. Changes in TERRA’s expression can lead to telomeric dysfunction, interfere with the replicative machinery and impact telomere length. TERRA also co-localizes in vivo with telomerase, and can form RNA:DNA hybrid structures called R-loops, which have been implicated in the onset of senescence and the alternative lengthening of telomere (ALT) pathway. Yet, the molecular mechanisms involving TERRA, as well as its function, remain elusive. Here, we review the current knowledge of TERRA transcription, structure, expression, regulation and its multiple telomeric and extra-telomeric functions in the budding yeast Saccharomyces cerevisiae.
Retrospective Study of Tick Bites Associated with Neurological Disease in a Level Three University Hospital in Switzerland
Authors: Thalmann Patrick , Ehrhard Simone , Summerfield Artur , Ricklin Meret Elisabeth
Published: March 2023

Background: Ticks represent very important vectors of human and zoonotic pathogens, and tick-borne diseases (TBDs) are diagnosed with increasing frequency. Therefore, the aim of this retrospective study was to describe patients presenting with a complaint of tick bite in the emergency department (ED) of a large university hospital in Switzerland. Methods: Data were collected by searching for keywords in the routine clinic database to identify cases from 1 July 2012 to 30 June 2020. The patients’ data were screened for preexisting diseases and demographic and clinical characteristics. Results: We included 415 patients collected over a period of 8 years, with highest admission frequencies from May to July. Of these, 82% were outpatients, 15.9% admitted to a hospital ward, and five to intensive care. The patients were allocated to three groups. The first group represented patients with erythema chronica migrans (ECM), which is pathognomonic for Lyme borreliosis (n = 45). Accordingly, 89% of cases in this group of patients were treated with antibiotics. The second group represented patients with other tick bite-associated erythema (n = 139). In this group, no particular clinical symptoms or laboratory findings were found. Finally, the largest group represented patients in which the tick bite was no longer visible (n = 201). This group of patients had significantly more evidence of neurological disorders (52%) and were treated at a higher rate with non-steroidal anti-inflammatory (29%) or antiviral (13%) drugs. Although the vaccination status for tick-borne encephalitis virus (TBEV) was not systematically evaluated, at least 10% of the latter group was vaccinated, indicating another source for neurological disease. Furthermore, only 14% of the tested patients were positive for IgM or IgG against TBEV. Conclusion: This retrospective study indicates the presence of many undiagnosed neurological diseases following tick bites that could be caused by TBEV or an unknown infectious agent. Taken together, although tick bites were not very frequently seen in the present tertiary ED, the frequent presence of neurological symptoms demands a more systematic assessment of vaccination status and TBEV serology as well as further diagnostic evaluations in patients that report tick bites and neurological symptoms.
Four Futures for Occupational Safety and Health
Authors: Felknor Sarah , Streit Jessica , Edwards Nicole , Howard John
Published: March 2023

Rapid changes to the nature of work have challenged the capacity of existing occupational safety and health (OSH) systems to ensure safe and productive workplaces. An effective response will require an expanded focus that includes new tools for anticipating and preparing for an uncertain future. Researchers at the U.S. National Institute for Occupational Safety and Health (NIOSH) have adopted the practice of strategic foresight to structure inquiry into how the future will impact OSH. Rooted in futures studies and strategic management, foresight creates well-researched and informed future scenarios that help organizations better prepare for potential challenges and take advantage of new opportunities. This paper summarizes the inaugural NIOSH strategic foresight project, which sought to promote institutional capacity in applied foresight while exploring the future of OSH research and practice activities. With multidisciplinary teams of subject matter experts at NIOSH, we undertook extensive exploration and information synthesis to inform the development of four alternative future scenarios for OSH. We describe the methods we developed to craft these futures and discuss their implications for OSH, including strategic responses that can serve as the basis for an action-oriented roadmap toward a preferred future.
Integrating Structured and Unstructured EHR Data for Predicting Mortality by Machine Learning and Latent Dirichlet Allocation Method
Authors: Chiu Chih-Chou , Wu Chung-Min , Chien Te-Nien , Kao Ling-Jing , Li Chengcheng , Chu Chuan-Mei
Published: March 2023

An ICU is a critical care unit that provides advanced medical support and continuous monitoring for patients with severe illnesses or injuries. Predicting the mortality rate of ICU patients can not only improve patient outcomes, but also optimize resource allocation. Many studies have attempted to create scoring systems and models that predict the mortality of ICU patients using large amounts of structured clinical data. However, unstructured clinical data recorded during patient admission, such as notes made by physicians, is often overlooked. This study used the MIMIC-III database to predict mortality in ICU patients. In the first part of the study, only eight structured variables were used, including the six basic vital signs, the GCS, and the patient’s age at admission. In the second part, unstructured predictor variables were extracted from the initial diagnosis made by physicians when the patients were admitted to the hospital and analyzed using Latent Dirichlet Allocation techniques. The structured and unstructured data were combined using machine learning methods to create a mortality risk prediction model for ICU patients. The results showed that combining structured and unstructured data improved the accuracy of the prediction of clinical outcomes in ICU patients over time. The model achieved an AUROC of 0.88, indicating accurate prediction of patient vital status. Additionally, the model was able to predict patient clinical outcomes over time, successfully identifying important variables. This study demonstrated that a small number of easily collectible structured variables, combined with unstructured data and analyzed using LDA topic modeling, can significantly improve the predictive performance of a mortality risk prediction model for ICU patients. These results suggest that initial clinical observations and diagnoses of ICU patients contain valuable information that can aid ICU medical and nursing staff in making important clinical decisions.
Texting While Driving: A Literature Review on Driving Simulator Studies
Authors: Voinea Gheorghe-Daniel , Boboc Răzvan Gabriel , Buzdugan Ioana-Diana , Antonya Csaba , Yannis George
Published: March 2023

Road safety is increasingly threatened by distracted driving. Studies have shown that there is a significantly increased risk for a driver of being involved in a car crash due to visual distractions (not watching the road), manual distractions (hands are off the wheel for other non-driving activities), and cognitive and acoustic distractions (the driver is not focused on the driving task). Driving simulators (DSs) are powerful tools for identifying drivers’ responses to different distracting factors in a safe manner. This paper aims to systematically review simulator-based studies to investigate what types of distractions are introduced when using the phone for texting while driving (TWD), what hardware and measures are used to analyze distraction, and what the impact of using mobile devices to read and write messages while driving is on driving performance. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) guidelines. A total of 7151 studies were identified in the database search, of which 67 were included in the review, and they were analyzed in order to respond to four research questions. The main findings revealed that TWD distraction has negative effects on driving performance, affecting drivers’ divided attention and concentration, which can lead to potentially life-threatening traffic events. We also provide several recommendations for driving simulators that can ensure high reliability and validity for experiments. This review can serve as a basis for regulators and interested parties to propose restrictions related to using mobile phones in a vehicle and improve road safety.
Narratives of Women and Gender Relations in Chinese COVID-19 Frontline Reports in 2020
Authors: Fang Shuoyu , Zou Li
Published: March 2023

This article analyzes the representation of women in Chinese news reports about COVID-19 in order to examine the consequences of the pandemic on gender relations in China. It draws on the linguistic framework of appraisal theory for identifying evaluative language and takes Chinese news reports on the COVID-19 frontline in 2020 as the major data sources. The study finds that while the narrative about women’s capacity in combating the virus, resolution in the face of adversity, and sense of responsibility help build a shared feeling of community to reconstruct the disturbed social order, the descriptions about the evaluation and feelings of female characters lead to undesirable outcomes in gender relations in China. Specifically, the newspapers’ reports on COVID-19 mainly focus on group interests and accomplishments and overlook women’s contributions in containing the pandemic. Meanwhile, the news reports devoted to constructing model female characters that highlight transcendent qualities place considerable pressure on everyday women. Furthermore, journalists tend to infuse their reports with gender bias when depicting women, including aesthetic appreciation of appearance and a focus on emotional reactions and domestic roles, which hinders the professional identity of women. This article sheds light on gender relations in China amid the pandemic, as well as the study of gender equality in media discourse.
A Realist Evaluation of Case Management Models for People with Complex Health Conditions Using Novel Methods and Tools—What Works, for Whom, and under What Circumstances?
Authors: Lukersmith Sue , Salvador-Carulla Luis , Chung Younjin , Du Wei , Sarkissian Anoush , Millington Michael
Published: March 2023

Case management developed from a generalist model to a person-centred model aligned with the evidence-informed evolution of best practice people-centred integrated care. Case management is a multidimensional and collaborative integrated care strategy where the case manager performs a set of interventions/actions to support the person with a complex health condition to progress in their recovery pathway and participate in life roles. It is currently unknown what case management model works in real life for whom and under what circumstances. The purpose of this study was to answer these questions. The study methods used realistic evaluation framework, examined the patterns and associations between case manager actions (mechanisms), the person’s characteristics and environment (context), and recovery (outcomes) over 10 years post severe injury. There was mixed methods secondary analysis of data extracted via in-depth retrospective file reviews (n = 107). We used international frameworks and a novel approach with multi-layered analysis including machine learning and expert guidance for pattern identification. The study results confirm that when provided, a person-centred case management model contributes to and enhances the person’s recovery and progress towards participation in life roles and maintaining well-being after severe injury.Furthermore, the intensity of case management for people with traumatic brain injury, and the person-centred actions of advising, emotional and motivational support, and proactive coordination contribute to the person achieving their goals. The results provide learnings for case management services on the case management models, for quality appraisal, service planning, and informs further research on case management.
Risk-Based Assessment of 132 kV Electric Distribution Substations and Proximal Residential Areas in the Mangaung Metropolitan Region
Authors: Rathebe Phoka Caiphus , Mbazima Setlamorago Jackson
Published: March 2023

Annually, an estimate of 2.3 million workers die prematurely due to occupational injuries and illnesses. In this study, a risk assessment was conducted to evaluate the compliance of 132 kV electric distribution substations and proximal residential areas with the South African occupational health and safety Act 85 of 1993. Data were collected from 30 electric distribution substations and 30 proximal residential areas using a checklist. Distribution substations of 132 kV were assigned an overall compliance value of ≥80%, while a composite risk value of < 0.5 was assigned to individual residential areas. The Shapiro–Wilk test was used to check for data normality before multiple comparisons and the Bonferroni adjustment was applied. Non-compliances in electric distribution substations were as a result of poor housekeeping and inappropriate fencing conditions. Ninety-three percent of the electric distribution substations (28/30) scored < 75% compliance on housekeeping and 30% (7/30) were non-compliant (<100%) on fencing. Conversely, there was compliance in the proximal residential areas concerning the substations. Statistically significant differences were found when substation positioning and surrounding infrastructure (p < 0.00), electromagnetic field sources (p < 0.00) and maintenance/general tidiness (p < 0.00) were compared. A peak risk value of 0.6 was observed when comparing the substation positioning with proximal electromagnetic field sources in the residential area. Housekeeping and fencing in the distribution substations must be improved to prevent occupational incidents such as injuries, fire outbreaks, theft and vandalism.
Familial Mediterranean Fever in Spain: Time Trend and Spatial Distribution of the Hospitalizations
Authors: Gallego Elisa , Arias-Merino Greta , Sánchez-Díaz Germán , Villaverde-Hueso Ana , Posada de la Paz Manuel , Alonso-Ferreira Verónica
Published: March 2023

Familial Mediterranean Fever (FMF) is a rare, hereditary, auto-inflammatory disease. The aims of this study were to explore the time trend and geographical distribution of hospitalizations in Spain from 2008 to 2015. We identified hospitalizations of FMF from the Spanish Minimum Basic Data Set at hospital discharge, using ICD-9-CM code 277.31. Age-specific and age-adjusted hospitalization rates were calculated. The time trend and the average percentage change were analyzed using Joinpoint regression. Standardized morbidity ratios were calculated and mapped by province. A total of 960 FMF-related hospitalizations (52% men) were identified across the period 2008–2015, with an increase in hospitalizations of 4.9% per year being detected (p < 0.05). The risk of hospitalization was higher than expected for the national total (SMR > 1) in 13 provinces (5 in the Mediterranean area), and lower (SMR < 1) in 14 provinces (3 in the Mediterranean area). There was an increase in hospitalizations of patients with FMF in Spain throughout the study period, with a risk of hospitalization that was higher, though not exclusively so, in provinces along the Mediterranean coast. These findings contribute to the visibility of FMF and provide useful information for health planning. Further research should take into account new population-based information, in order to continue monitoring this disease.
Research on the Sustainable Renewal of Architectural Heritage Sites from the Perspective of Extenics—Using the Example of Tulou Renovations in LantianVillage, Longyan City
Authors: You Xianli , Zhang Yanqin , Tu Zhigang , Xu Linxin , Li Liyi , Lin Rong , Chen Kaida , Chen Shunhe , Ren Wei
Published: March 2023

Fujian Tulous in China are important international architectural heritage sites that reflect precious human cultural heritage. Currently, only a small number of Tulou buildings have been listed as world cultural heritage sites, resulting in a lack of attention and financial support for most Tulou buildings. Thus, it is difficult to effectively renovate and repair Tulou buildings to adapt to modern life, and therefore they are facing the severe challenge of abandonment and desolation. Due to the special conditions of Tulou buildings, there are significant limitations in renovation and repair work, with a number of problems such as the lack of innovative renovations. Therefore, through a problem model analysis of a design system for Tulou renovations, in this study, we adopt the methods of divergent tree, conjugate pair, correlative net, implied system, and split-merge chain analyses in extenics to carry out extension transformation and solve the problem and we verify its feasibility using the example of the Tulou renovation projects in Lantian Village, Longyan City. We explore an innovative methodology for scientific renovation of Tulou buildings, and we establish a design system for Tulou building renovations that enriches and supplements original renovation methods; thus, we provide a basis for the repair and reuse of Tulou buildings, to extend their service life and to realize the sustainable development of Tulou buildings. The research results show that extenics can be implemented in innovative renovations of Tulou buildings, and it is concluded that the essence of achieving sustainable renewal in Tulou building renovations is to solve contradictory problems, including contradictions in conditions, objectives, and design. This study verifies the possibility of applying extenics in the design of Tulou building renovations, makes corresponding contributions to the application of extension methods in the renovation and renewal of Tulou buildings, and also contributes to the renovation, renewal, and protection of other types of architectural heritage sites.
Intrinsic Capacities, Functional Ability, Physiological Systems, and Caregiver Support: A Targeted Synthesis of Effective Interventions and International Recommendations for Older Adults
Authors: Ashikali Eleni-Marina , Ludwig Catherine , Mastromauro Laura , Périvier Samuel , Tholomier Aude , Ionita Irina , Graf Christophe , Busnel Catherine
Published: March 2023

The ageing population calls for interventions that can assist older people to age healthily. This study aimed to provide a targeted synthesis of high-level research and current evidence-based recommendations on effective interventions for maintaining or preventing the decline in intrinsic capacity, functional ability, and physiological systems, or for caregiver support. Nestled within the healthy ageing framework by the World Health Organization, available evidence was selected in a targeted manner, with the purpose of providing a synthesis that would allow the application of this knowledge in real life. As such, the outcome variables were examined through an Evidence and Gap Map of interventions for functional ability and through guidelines from leading institutions. Systematic reviews, meta-analyses, and guidelines on community-dwelling older adults with or without minor health limitations were considered. Thirty-eight documents were included and over fifty interventions identified. Physical activity interventions were consistently effective across several domains. Recommendations point to screening, whilst highlighting the importance of behavioural factors in the endeavour to age healthily. There is a wide range of activities which are likely to foster healthy ageing. To encourage their uptake, it is important for communities to offer suitable promotion and support, and to make these accessible to the public.
Preventing Agricultural Non-Point Source Pollution in China: The Effect of Environmental Regulation with Digitization
Authors: Zhang Weikun , Gao Peng , Chen Zhe , Qiu Hailan
Published: March 2023

Environmental regulation (ER) is essential to preventing agricultural non-point source pollution (ANSP). Prior research has focused on the effect of ER on agricultural pollution (AP), but little is known about the impact of ER following digitization on preventing AP, particularly ANSP. Based on the spatial heterogeneity, the effect of ER was examined using a geographic detector tool with provincial panel data from 2010 to 2020 in rural China. The results show that ER is a driver in preventing ANSP, primarily because of the constraint on farmers’ behavior. Digitization positively affects the prevention of ANSP, as the new impetus for the infrastructure, technology, and capital is supported. The interaction between ER and digitalization forms a driving effect on the prevention of ANSP, indicating that digitalization constitutes the path dependence of farmers’ rule acquisition and perception and addresses the “free riding” dilemma of farmers’ participation, thereby enabling the incentive of ER to make agricultural production green and efficient. These findings indicate that the endogenous factor of digitization allowing ER is essential to preventing ANSP.
Efficiency Enhancement Strategies for Stable Bismuth-Based Perovskite and Its Bioimaging Applications
Authors: Xiao Liangyan , Huang Linwei , Su Weihaojia , Wang Tianjun , Liu Haiying , Wei Zhongchao , Fan Haihua
Published: March 2023

Lead-free perovskite is one of the ideal solutions for the toxicity and instability of lead halide perovskite quantum dots. As the most ideal lead-free perovskite at present, bismuth-based perovskite quantum dots still have the problem of a low photoluminescence quantum yield, and its biocompatibility also needs to be explored. In this paper, Ce3+ ions were successfully introduced into the Cs3Bi2Cl9 lattice using a modified antisolvent method. The photoluminescence quantum yield of Cs3Bi2Cl9:Ce is up to 22.12%, which is 71% higher than that of undoped Cs3Bi2Cl9. The two quantum dots show high water-soluble stability and good biocompatibility. Under the excitation of a 750 nm femtosecond laser, high-intensity up-conversion fluorescence images of human liver hepatocellular carcinoma cells cultured with the quantum dots were obtained, and the fluorescence of the two quantum dots was observed in the image of the nucleus. The fluorescence intensity of cells cultured with Cs3Bi2Cl9:Ce was 3.20 times of that of the control group and 4.54 times of the control group for the fluorescence intensity of the nucleus, respectively. This paper provides a new strategy to develop the biocompatibility and water stability of perovskite and expands the application of perovskite in the field.
Research on Optimization of Public Opinion Supervision Model of Social Network Platform Based on Evolutionary Game
Authors: Jin Chunhua , Zhai Xiaoxiao , Ma Yanhong
Published: March 2023

Network environments have recently emerged as a considerable research area. In addition to government supervision, platform supervision is also critical to improve network environments. So, we should improve the social network platform’s single regulatory model. Against this background, we described public opinion supervision as a game between marketing accounts, netizens, and the platform. Unlike previous studies, we considered the influence of marketing accounts on online public opinion. Because of the players’ bounded rationality, we built an evolutionary game model, and by solving it, we obtained the evolutionarily stable strategy (ESS). Then, we analyzed the influence of relevant parameters on the evolutionary stable state. Our research results show that if the authenticity of the information is not high, to not publish is the best choice for the marketing account, and to not participate is the best choice for the netizen. The platform penalty for the marketing account is also directly related to the marketing account’s decision making. The platform penalty for the government, as well as the increase in the penalty risk coefficient, considerably affected the choice of platform. Finally, we put forward the “pre-event–in-the-event–post-event” three-stage supervision model, which provides countermeasures and suggestions for all parties to jointly maintain the network environment.
The Split-Screen Approach for Project Appraisal (Part I: The Theory)
Authors: Magni Carlo Alberto
Published: March 2023

This paper illustrates an innovative approach to financial modeling of engineering decision-making and industrial projects. The approach is a minimal one, grounded as it is on three notions, two laws, and one matrix that combines them, called Split-Screen Matrix (SSM). This split-screen approach consists in linking the accounting and financial input data and systematizes them into the SSM, whose columns report the pro forma book values of capital (balance sheets), the corresponding income components (income statements), and the associated cash flows (cash-flow statements) while the rows show the project’s dynamical evolution. The SSMs are then linked via a continuous split-screen strip. To appraise the project, we use a pair of SSMs, namely, the project matrix and the benchmark Matrix (with the related strips), the latter containing the alternative amount invested and the associated foregone profit of a financial portfolio replicating the project’s cash flows. Using differences between the corresponding elements of the two strips, the economic profitability of the project can be easily measured, in both absolute terms (e.g., net present value, market value added, residual income) and relative terms (e.g., average return on assets, cash-flow return on capital). The accounting-and-finance engineering system (AFES) obtained with the split-screen approach is particularly helpful when using spreadsheet modeling because it does not require (knowledge and) use of financial spreadsheet functions. The application of this approach on spreadsheet modeling is essentially based on the continuous split-screen strip, here described, and is illustrated in a following paper (Baschieri and Magni 2023, “The Split-Screen Approach for Project Apraisal (Part II: Spreadsheet Modeling)”).
Modification of Iron-Rich Phase in Al-7Si-3Fe Alloy by Mechanical Vibration during Solidification
Authors: Sun Cuicui , Zhang Suqing , Zhou Jixue , Wu Jianhua , Zhang Xinfang , Wang Xitao
Published: March 2023

The plate-like iron-rich intermetallic phases in recycled aluminum alloys significantly deteriorate the mechanical properties. In this paper, the effects of mechanical vibration on the microstructure and properties of the Al-7Si-3Fe alloy were systematically investigated. Simultaneously, the modification mechanism of the iron-rich phase was also discussed. The results indicated that the mechanical vibration was effective in refining the α-Al phase and modifying the iron-rich phase during solidification. The forcing convection and a high heat transfer inside the melt to the mold interface caused by mechanical vibration inhibited the quasi-peritectic reaction: L + α-Al8Fe2Si → (Al) + β-Al5FeSi and eutectic reaction: L → (Al) + β-Al5FeSi + Si. Thus, the plate-like β-Al5FeSi phases in traditional gravity-casting were replaced by the polygonal bulk-like α-Al8Fe2Si. As a result, the ultimate tensile strength and elongation were increased to 220 MPa and 2.6%, respectively.
Selective Blocking of Graphene Defects Using Polyvinyl Alcohol through Hydrophilicity Difference
Authors: Kim Yoon-jeong , Kim Yang Hui , Ahn Seokhoon
Published: March 2023

Defects on graphene over a micrometer in size were selectively blocked using polyvinyl alcohol through the formation of hydrogen bonding with defects. Because this hydrophilic PVA does not prefer to be located on the hydrophobic graphene surface, PVA selectively filled hydrophilic defects on graphene after the process of deposition through the solution. The mechanism of the selective deposition via hydrophilic–hydrophilic interactions was also supported by scanning tunneling microscopy and atomic force microscopy analysis of selective deposition of hydrophobic alkanes on hydrophobic graphene surface and observation of PVA initial growth at defect edges.
Influence of Microstructure on Fracture Mechanisms of the Heat-Treated AlSi10Mg Alloy Produced by Laser-Based Powder Bed Fusion
Authors: Di Egidio Gianluca , Martini Carla , Börjesson Johan , Ghassemali Ehsan , Ceschini Lorella , Morri Alessandro
Published: March 2023

Few systematic studies on the correlation between alloy microstructure and mechanical failure of the AlSi10Mg alloy produced by laser-based powder bed fusion (L-PBF) are available in the literature. This work investigates the fracture mechanisms of the L-PBF AlSi10Mg alloy in as-built (AB) condition and after three different heat treatments (T5 (4 h at 160 °C), standard T6 (T6B) (1 h at 540 °C followed by 4 h at 160 °C), and rapid T6 (T6R) (10 min at 510 °C followed by 6 h at 160 °C)). In-situ tensile tests were conducted with scanning electron microscopy combined with electron backscattering diffraction. In all samples the crack nucleation was at defects. In AB and T5, the interconnected Si network fostered damage at low strain due to the formation of voids and the fragmentation of the Si phase. T6 heat treatment (T6B and T6R) formed a discrete globular Si morphology with less stress concentration, which delayed the void nucleation and growth in the Al matrix. The analysis empirically confirmed the higher ductility of the T6 microstructure than that of the AB and T5, highlighting the positive effects on the mechanical performance of the more homogeneous distribution of finer Si particles in T6R.
Natrium Diacid Phosphate-Manganese-Lead Vitroceramics Obtained from Spent Electrodes
Authors: Cuibus Denisa , Rada Simona , Macavei Sergiu , Vermesan Horatiu
Published: March 2023

NaH2PO4-MnO2-PbO2-Pb vitroceramics were studied usinginfrared (IR), ultraviolet-visible (UV-Vis) and electron paramagnetic resonance (EPR) spectroscopies to understand the structural modifications as potential candidates for electrode materials. The electrochemical performances of the NaH2PO4-MnO2-PbO2-Pb materials were investigated through measurements of cyclic voltammetry. Analysis of the results indicates that doping with a suitable content of MnO2 and NaH2PO4 removes hydrogen evolution reactions and produces a partial desulphatization of the anodic and cathodic plates of the spent lead acid battery.
Calcium-Based Binders in Concrete or Soil Stabilization: Challenges, Problems, and Calcined Clay as Partial Replacement to Produce Low-Carbon Cement
Authors: Mohammed Angham Ali , Nahazanan Haslinda , Nasir Noor Azline Mohd , Huseien Ghasan Fahim , Saad Ahmed Hassan
Published: March 2023

Calcium-based binders, such as ordinary Portland cement (OPC) and lime (CaO), are the most common artificial cementitious materials used worldwide for concrete and soil improvement. However, using cement and lime has become one of the main concerns for engineers because they negatively affect the environment and economy, prompting research into alternative materials. The energy consumption involved in producing cementitious materials is high, and the subsequent CO2 emissions account for 8% of the total CO2 emissions. In recent years, an investigation into cement concrete’s sustainable and low-carbon characteristics has become the industry’s focus, achieved by using supplementary cementitious materials. This paper aims to review the problems and challenges encountered when using cement and lime. Calcined clay (natural pozzolana) has been used as a possible supplement or partial substitute to produce low-carbon cement or lime from 2012–2022. These materials can improve the concrete mixture’s performance, durability, and sustainability. Calcined clay has been utilized widely in concrete mixtures because it produces a low-carbon cement-based material. Owing to the large amount of calcined clay used, the clinker content of cement can be lowered by as much as 50% compared with traditional OPC. It helps conserve the limestone resources used in cement manufacture and helps reduce the carbon footprint associated with the cement industry. Its application is gradually growing in places such as Latin America and South Asia.
The Microzone Structure Regulation of Diamond/Cu-B Composites for High Thermal Conductivity: Combining Experiments and First-Principles Calculations
Authors: Xie Zhongnan , Xiao Wei , Guo Hong , Xue Boyu , Yang Hui , Zhang Ximin , Huang Shuhui , Sun Mingmei , Xie Haofeng
Published: March 2023

The interface microzone characteristics determine the thermophysical properties of diamond/Cu composites, while the mechanisms of interface formation and heat transport still need to be revealed. Here, diamond/Cu-B composites with different boron content were prepared by vacuum pressure infiltration. Diamond/Cu-B composites up to 694 W/(mK) were obtained. The interfacial carbides formation process and the enhancement mechanisms of interfacial heat conduction in diamond/Cu-B composites were studied by HRTEM and first-principles calculations. It is demonstrated that boron can diffuse toward the interface region with an energy barrier of 0.87 eV, and these elements are energetically favorable to form the B4C phase. The calculation of the phonon spectrum proves that the B4C phonon spectrum is distributed in the range of the copper and diamond phonon spectrum. The overlapping of phonon spectra and the dentate structure together enhance the interface phononic transport efficiency, thereby improving the interface thermal conductance.
Thiol-Ene Photo-Click Hydrogels with Tunable Mechanical Properties Resulting from the Exposure of Different -Ene Moieties through a Green Chemistry
Authors: Laurano Rossella , Boffito Monica , Cassino Claudio , Midei Ludovica , Pappalardo Roberta , Chiono Valeria , Ciardelli Gianluca
Published: March 2023

Temperature and light responsiveness are widely exploited stimuli to tune the physico-chemical properties of double network hydrogels. In this work, new amphiphilic poly(ether urethane)s bearing photo-sensitive moieties (i.e., thiol, acrylate and norbornene functionalities) were engineered by exploiting the versatility of poly(urethane) chemistry and carbodiimide-mediated green functionalization procedures. Polymers were synthesized according to optimized protocols maximizing photo-sensitive group grafting while preserving their functionality (approx. 1.0 × 1019, 2.6 × 1019 and 8.1 × 1017 thiol, acrylate and norbornene groups/gpolymer), and exploited to prepare thermo- and Vis-light-responsive thiol-ene photo-click hydrogels (18% w/v, 1:1 thiol:ene molar ratio). Green light-induced photo-curing allowed the achievement of a much more developed gel state with improved resistance to deformation (ca. 60% increase in critical deformation, γL). Triethanolamine addition as co-initiator to thiol-acrylate hydrogels improved the photo-click reaction (i.e., achievement of a better-developed gel state). Differently, L-tyrosine addition to thiol-norbornene solutions slightly hindered cross-linking, resulting in less developed gels with worse mechanical performances (~62% γL decrease). In their optimized composition, thiol-norbornene formulations resulted in prevalent elastic behavior at lower frequency compared to thiol-acrylate gels due to the formation of purely bio-orthogonal instead of heterogeneous gel networks. Our findings highlight that exploiting the same thiol-ene photo-click chemistry, a fine tuning of the gel properties is possible by reacting specific functional groups.
Comparative Analysis of Elastic Polyester Sportswear Fabrics with Printed Graphene Patterns
Authors: Vasile Simona , Georgievska Magdalena , Copot Cosmin , De Raeve Alexandra
Published: March 2023

In this study two elastic polyester fabrics differentiated by a graphene-printed pattern, called honeycomb (HC) and spider web (SW), were analyzed with a focus on their thermal, mechanical, moisture management and sensorial properties, aiming to identify the fabric with the most elevated heat dissipation and comfort for sportswear. The shape of the graphene-printed circuit did not lead to significant difference between the mechanical properties of the fabrics SW and HC assessed by the Fabric Touch Tester (FTT). Fabric SW outperformed fabric HC with respect of drying time, air permeability, moisture, and liquid management properties. On the other hand, both the Infrared (IR) thermography and FTT-predicted warmness clearly showed that fabric HC dissipates heat faster on its surface along the graphene circuit. This fabric was also predicted by the FTT as smoother and softer than fabric SW and had a better overall fabric hand. The results revealed that both graphene patterns resulted in comfortable fabrics with great potential applications in sportswear fields, in specific use scenario’s.
A Novel Non-Isolated High-Gain Non-Inverting Interleaved DC–DC Converter
Authors: Mumtaz Farhan , Yahaya Nor Zaihar , Meraj Sheikh Tanzim , Singh Narinderjit Singh Sawaran , Abro Ghulam E Mustafa
Published: March 2023

High-gain DC–DC converters are being drastically utilized in renewable energy generation systems, such as photovoltaic (PV) and fuel cells (FC). Renewable energy sources (RES) persist with low-level output voltage; therefore, high-gain DC–DC converters are essentially integrated with RES for satisfactory performance. This paper proposes a non-isolated high-gain non-inverting interleaved DC–DC boost converter. The proposed DC–DC converter topology is comprised of two inductors and these are charging and discharging in series and parallel circuit configurations. The voltage multiplier technique is being utilized to produce high gain. The proposed topology is designed to operate in three modes of operation. Three switches are operated utilizing two distinct duty ratios to avoid the extreme duty ratio while having high voltage gain. Owing to its intelligent design, the voltage stress on the switches is also significantly reduced where the maximum stress is only 50% of the output voltage. The proposed converter’s steady-state analysis with two distinct duty ratios is thoroughly explored. Furthermore, a 160 W 20/400 V prototype is developed for performance analysis and validation. The converter topology can generate output voltage with a very high voltage gain of 20, which is verified by the prototype. Moreover, a high efficiency of 93.2% is attained by the proposed converter’s hardware prototype.