bluuebunny/crossref_metadata_2025 huggingface dataset:
Wounding and methyl jasmonate increase cyanogenic glucoside concentrations in Sorghum bicolor via upregulation of biosynthesis
Authors: Sohail M. N. , O'Donnell N. H. , Kaiser B. N. , Blomstedt C. K. , Gleadow R. M.
Published: March 2023

The cyanogenic glucoside, dhurrin, present in Sorghum bicolor is thought to have multiple functions, including in defence against herbivory. The hormone methyl jasmonate (MeJA) is also induced by herbivory and is key to instigating defence processes in plants.

To investigate whether dhurrin is induced in response to herbivore attack and also to the associated presence of MeJA, sorghum plants were either wounded or exogenous MeJA was applied.

We show that specific wounding (pin board and perforation) and the application of MeJA increases dhurrin concentration in leaves and sheath tissue 12 h after treatment.

Quantitative PCR shows that the expression of two genes, SbCYP79A1 and SbUGT85B1, involved in the synthesis of dhurrin are significantly induced by exogenous MeJA and by wounding. Analysis of 2 kb of sequence upstream of the start codon of SbCYP79A1 identifies several cis‐acting elements that have been linked to MeJA induction. A promoter deletion series, coupled to GFP, and transiently expressed in Nicotiana benthamiana suggests that there are potentially three sequence motifs (~−925 to −976) involved in the binding of transcription factors that result in increased expression of SbCYP79A1 and the synthesis of dhurrin in response to MeJA.
SharpRazor: Automatic removal of hair and ruler marks from dermoscopy images
Authors: Kasmi Reda , Hagerty Jason , Young Reagan , Lama Norsang , Nepal Januka , Miinch Jessica , Stoecker William , Stanley R Joe
Published: March 2023

Background

The removal of hair and ruler marks is critical in handcrafted image analysis of dermoscopic skin lesions. No other dermoscopic artifacts cause more problems in segmentation and structure detection.

Purpose

The aim of the work is to detect both white and black hair, artifacts and finally inpaint correctly the image.

Method

We introduce a new algorithm: SharpRazor, to detect hair and ruler marks and remove them from the image. Our multiple‐filter approach detects hairs of varying widths within varying backgrounds, while avoiding detection of vessels and bubbles. The proposed algorithm utilizes grayscale plane modification, hair enhancement, segmentation using tri‐directional gradients, and multiple filters for hair of varying widths. We develop an alternate entropy‐based processing adaptive thresholding method. White or light‐colored hair, and ruler marks are detected separately and added to the final hair mask. A classifier removes noise objects. Finally, a new technique of inpainting is presented, and this is utilized to remove the detected object from the lesion image.

Results

The proposed algorithm is tested on two datasets, and compares with seven existing methods measuring accuracy, precision, recall, dice, and Jaccard scores. SharpRazor is shown to outperform existing methods.

Conclusion

The Shaprazor techniques show the promise to reach the purpose of removing and inpaint both dark and white hair in a wide variety of lesions.
SWIP mediates retromer‐independent membrane recruitment of the WASH complex
Authors: Dostál Vojtěch , Humhalová Tereza , Beránková Pavla , Pácalt Ondřej , Libusová Lenka
Published: March 2023

The pentameric WASH complex facilitates endosomal protein sorting by activating Arp2/3, which in turn leads to the formation of F‐actin patches specifically on the endosomal surface. It is generally accepted that WASH complex attaches to the endosomal membrane via the interaction of its subunit FAM21 with the retromer subunit VPS35. However, we observe the WASH complex and F‐actin present on endosomes even in the absence of VPS35. We show that the WASH complex binds to the endosomal surface in both a retromer‐dependent and a retromer‐independent manner. The retromer‐independent membrane anchor is directly mediated by the subunit SWIP. Furthermore, SWIP can interact with a number of phosphoinositide species. Of those, our data suggest that the interaction with phosphatidylinositol‐3,5‐bisphosphate (PI(3,5)P2) is crucial to the endosomal binding of SWIP. Overall, this study reveals a new role of the WASH complex subunit SWIP and highlights the WASH complex as an independent, self‐sufficient trafficking regulator.
Architecture-Driven Physics-Informed Deep Learning for Temperature Prediction in Laser Powder Bed Fusion Additive Manufacturing With Limited Data
Authors: Ghungrad Suyog , Faegh Meysam , Gould Benjamin , Wolff Sarah J. , Haghighi Azadeh
Published: March 2023

Physics-informed deep learning (PIDL) is one of the emerging topics in additive manufacturing (AM). However, the success of previous PIDL approaches is generally significantly dependent on the existence of massive datasets. As the data collection in AM is usually challenging, a novel Architecture-driven PIDL structure named APIDL based on the deep unfolding approach for limited data scenarios has been proposed in the current study for predicting thermal history in the laser powder bed fusion process. The connections in this machine learning architecture are inspired by iterative thermal model equations. In other words, each iteration of the thermal model is mapped to a layer of the neural network. The hyper-parameters of the APIDL model are tuned, and its performance is analyzed. The APIDL for 1000 points with 80:20 split ratio achieves testing mean absolute percentage error (MAPE) of 2.8% and R2 value of 0.936. The APIDL is compared with the artificial neural network, extra trees regressor (ETR), support vector regressor, and long short-term memory algorithms. It was shown that the proposed APIDL model outperforms the others. The MAPE and R2 of APIDL are 55.7% lower and 15.6% higher than the ETR, which had the best performance among other pure machine learning models.
Bridging the Built and Social Environments: A Systematic Review of Studies Investigating Influences on Physical Activity
Authors: Prochnow Tyler , Curran Laurel S. , Amo Christina , Patterson Meg S.
Published: March 2023

Background: The purpose of this review was to examine articles assessing aspects of the built and social environment simultaneously, and how these environments influence physical activity (PA). A thorough review of studies is needed to identify patterns across studies and gaps for future research and practice. Methods: To be included, articles needed to contain: (1) self-report or objective measure of PA; (2) a measure of the built environment; (3) a measure of the social environment; and (4) an analysis between built environment, social environment, and PA. A systematic literature search of 4358 articles resulted in 87 articles. Results: Several populations were present within the sample including various age groups and different countries. As previously established, the built environment and social environment were consistently associated with PA; however, mediating factors between these 2 layers were less clear. Further, there was a lack of longitudinal and experimental study designs. Conclusions: Results suggest a need for longitudinal and experimental designs with validated and granular measures. As communities recover from the COVID-19 pandemic, a thorough understanding of how built environment factors enhance or detract from social connectedness and how this reciprocal relationship impacts PA behavior is needed for future policy, environment, and systematic change.
A Deep-Sea Bacterium Is Capable of Degrading Polyurethane
Authors: Gui Zhi , Liu Guangchao , Liu Xin , Cai Ruining , Liu Rui , Sun Chaomin
Published: March 2023

The widespread and indiscriminate disposal of plastics inevitably leads to environmental pollution. The secondary pollution by current landfill and incineration methods causes serious damage to the atmosphere, land, and rivers.
Unification: Viscosity, permittivity, and hydration forces near an interface
Authors: Zhdanov Vladimir P.
Published: March 2023

In water-based solutions near interfaces, the hydration forces, dielectric permittivity, and viscosity depend on the short-range order in the arrangement of water molecules. The former two quantities were earlier rationalized by employing the Ginzburg–Landau expression for the solution free energy. Driven by the spirit of unification, we show that the dependence of the viscosity coefficient on the coordinate perpendicular to the interface can be rationalized in this framework as well by using in addition a linear Evans–Polanyi correlation between the activation energy determining viscosity and the solution free energy. In the conventional hydrodynamics, this effect is often formally described by introducing the partial-slip boundary conditions or a stagnant layer near interfaces. We show how the corresponding slip or stagnant-layer length can be explained and quantified.
LOCAL TIME FRACTIONAL REDUCED DIFFERENTIAL TRANSFORM METHOD FOR SOLVING LOCAL TIME FRACTIONAL TELEGRAPH EQUATIONS
Authors: CHU YU-MING , JNEID MAHER , CHAOUK ABIR , INC MUSTAFA , REZAZADEH HADI , HOUWE ALPHONSE
Published: March 2023

In this paper, we seek to find solutions of the local time fractional Telegraph equation (LTFTE) by employing the local time fractional reduced differential transform method (LTFRDTM). This method produces a numerical approximate solution having the form of an infinite series that converges to a closed form solution in many cases. We apply LTFRDTM on four different LTFTEs to examine the efficiency of the proposed method. The yielded results established the effectiveness of LTFRDTM as a reliable and solid approach for obtaining solutions of LTFTEs. The solutions coincided with the exact solution in the ordinary case when [Formula: see text]. It also required minimal amount of computational work and saved a lot of time.
CALCULUS OPERATORS AND SPECIAL FUNCTIONS ASSOCIATED WITH KOHLRAUSCH–WILLIAMS–WATTS AND MITTAG-LEFFLER FUNCTIONS
Authors: YANG XIAO-JUN , GENG LU-LU , PAN YU-MEI , YU XIAO-JIN
Published: March 2023

In this paper, many important formulas of the subtrigonometric, subhyperbolic, pretrigonometric, prehyperbolic, supertrigonometric, and superhyperbolic functions sin Wiman class are developed for the first time. The subsine, subcosine, subhyperbolic sine, and subhyperbolic cosine associated with Kohlrausch–Williams–Watts (KWW) function and their scaling-law ODEs are proposed. The supersine, supercosine, superhyperbolic sine, and superhyperbolic cosine functions associated with Mittag-Leffler (ML) function and their fractional ODEs are obtained. The conjectures for the supercosine functions containing ML function are presented in detail.
A bijection theorem for Gorenstein projective τ-tilting modules
Authors: Xie Zongzhen , Zhang Xiaojin
Published: March 2023

We introduce the notions of Gorenstein projective [Formula: see text]-rigid modules, Gorenstein projective support [Formula: see text]-tilting modules and Gorenstein torsion pairs and give a Gorenstein analog to Adachi–Iyama–Reiten’s bijection theorem on support [Formula: see text]-tilting modules. More precisely, for an algebra [Formula: see text], we prove that there is a bijection between the set of Gorenstein projective support [Formula: see text]-tilting modules and the set of functorially finite Gorenstein projective torsion classes. As an application, we introduce the notion of CM-[Formula: see text]-tilting finite algebras and show that [Formula: see text] is CM-[Formula: see text]-tilting finite if and only if [Formula: see text] is CM-[Formula: see text]-tilting finite. Moreover, we show that the Bongartz completion of a Gorenstein projective [Formula: see text]-rigid module need not be a Gorenstein projective [Formula: see text]-tilting module.
A Think-Aloud Study of Novice Debugging
Authors: Whalley Jacqueline , Settle Amber , Luxton-Reilly Andrew
Published: March 2023

Debugging is a core skill required by programmers, yet we know little about how to effectively teach the process of debugging. The challenges of learning debugging are compounded for novices who lack experience and are still learning the tools they need to program effectively. In this work, we report a case study in which we used a think-aloud protocol to gain insight into the behaviour of three students engaged in debugging tasks. Our qualitative analysis reveals a variety of helpful practices and barriers that limit the effectiveness of debugging. We observe that comprehension, evidence-based activities, and workflow practices all contribute to novice debugging success. Lack of sustained effort, precision, and methodical processes negatively impact debugging effectiveness. We anticipate that understanding how students engage in debugging tasks will aid future work to address ineffective behaviours and promote effective debugging activities.
Letter writing assignment for exercise physiology students
Authors: Nuzzo James L.
Published: March 2023

Letters to the editor are a form of postpublication review and thus help to refine knowledge through discussion and debate, yet exercise physiology students are rarely introduced to letters in their formal education. Here, the author proposes a lecture and an assignment that the university educator can use to help students understand the importance of letters. In the assignment, the student, among other tasks, critiques an existing letter exchange and writes a letter for potential publication.
Classification of the Traffic Status Subcategory with ETC Gantry Data: An Improved Support Tensor Machine Approach
Authors: Zhao Yan , Lu Wenqi , Rui Yikang , Ran Bin
Published: March 2023

Accurate and reliable traffic state identification is the prerequisite for developing intelligent traffic programs. With the improvement of intelligent traffic control measures, the traffic state of some highways has gradually stabilized. The current research on traffic state identification needs to fully meet the highly informative intelligent traffic system and traffic state subcategory analysis. To fill the gap above, we propose an improved support tensor machine (STM) method based on self-training and multiclassification for traffic state subcategory identification (ISTM) with ETC gantry data. This paper takes the excellent application of the support vector machine (SVM) in traffic state identification as the starting point of method design and extends to the STM. The ETC gantry data are represented as a third-order tensor model. This paper utilizes the similarity among tensor samples to construct the kernel function and recognize the traffic states. We simplify STM calculation with a one-against-one model and a self-training idea. An optimal fit of the characteristics is supplied by maximizing inter-subcategory tensor block distances and minimizing intra-subcategory tensor block distances throughout a joint utilization of the STM and multiscale training theories. The experiment in this paper uses ETC gantry data from the Jingtai highway in Shandong Province, and the findings reveal that the ISTM has optimum values of 0.2578 and 0.3254 for the SumD and 0.1718 and 0.1901 for the DBI as compared to K-mean clustering and the SVM. The ISTM trains the traffic state subcategory classifiers with high accuracy and strong generalization ability.
An Ultrashort-Term Wind Power Prediction Method Based on a Switching Output Mechanism
Authors: Feng Rongqiang , Wang Biheng , Wu Xueqiong , Huang Chenxi , Zhao Lei , Tang Wei , Zhang Kun , Huang Xiaoming , Ding Wei
Published: March 2023

The ultrashort-term wind power prediction (USTWPP) technology assists the grid to arrange spare capacity, which is important to optimize power investment reasonably. To improve the accuracy of USTWPP and optimize power investment requirements, a USTWPP method with dynamic switching of multiple models is proposed. For high wind speed fluctuation samples, the wind speed-power curve (WSPC) is fitted in a large sample of historical data, and the corrected wind speed is the input of WSPC. The spatiotemporal attentive network model (STAN) is built for the prediction of low wind speed fluctuation samples. According to the real-time fluctuation characteristics of the correction wind speed, a switching mechanism between multiple models is established to reconstruct the prediction results along the time axis direction, and the predicted power is set to zero for the samples whose correction wind speed is lower than the cut-in wind speed. We conducted simulation experiments with data provided by a wind farm with an installed capacity of 130.5 MW in China. The normalized root mean square error (NRMSE) for the 4 h ahead predicted power reaches 0.0907, which verified the validity and applicability of the proposed model.
Influence Analysis of Rock Mass Mechanical Properties on Tunnel Rock Stability Based on Sensor Data Integration
Authors: Li Song , Chen Yanxiang , Guo Enping , Huang Linhua
Published: March 2023

This study takes the multisensor monitoring data of tunnel support structure and surrounding rock mechanical properties during TBM construction as the research object, integrates the monitoring data of multisensor through an intelligent optimization algorithm, and explores the self‐consistent fusion characteristics between the multisensor structural mechanical properties and the field monitoring data. At the same time, the support structure parameters and construction progress in the tunnel construction process are dynamically adjusted and scientifically integrated through the information feedback of monitoring data. The research results are as follows: (1) The tunnel excavation rate is different under different rock strengths and surrounding rock levels. The overall performance is that the harder the surrounding rock, the lower the surrounding rock level, and the faster the tunnel excavation rate. The relationship between the FPI parameters of surrounding rock and the deformation of tunnel surrounding rock is closer, and the correlation coefficient reaches 98%. The mechanical properties of the surrounding rock have the greatest influence on its deformation. (2) The rotation speed, thrust, and torque of TBM machinery as well as the surrounding rock workability index and the tunnel surrounding rock deformation maintain a good fitting relationship, with a fitting rate of more than 85%. After the improved PSO‐BP algorithm is used to calculate and fit the four parameters of torque, rotational speed, thrust, and surrounding rock drivable coefficient during TBM mechanical construction, the fitting accuracy is higher than 94%. (3) At the same time, according to the analysis of the fitting results, the fitting effect of TBM mechanical thrust is the best among the four‐parameter algorithm analysis fitting degrees, which is 99.3%. (4) The measured points are evenly distributed near the surrounding rock deformation surface calculated by the improved PSO‐BP algorithm, and the fitting variance is 0.972. With the tunnel excavation, the settlement deformation of surrounding rock first increases rapidly, and then, the settlement deformation enters a slow growth stage and finally reaches a relatively stable state. (5) After the jam occurs, the tunnel is expanded from the telescopic shield or tail shield to the outer side of the shield to reduce the contact area between the shield and the surrounding rock to reduce the extrusion of the surrounding rock pressure on the shield.
Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung Adenocarcinoma
Authors: Fan Zhengyang , Wu Song , Sang Hongyang , Li Qianping , Cheng Shaofei , Zhu Hongling
Published: March 2023

Lung adenocarcinoma (LUAD) is one of the most prevalent pathological kinds of lung cancer, which is a common form of cancer that has a high death rate. Over the past several years, growing studies have indicated that GPD1L was involved in the advancement of a number of different cancers. However, its clinical significance in LUAD has not been investigated. In this study, following an examination of the TGCA datasets, we found that GPD1L displayed a dysregulated state in a wide variety of cancers; this led us to believe that GPD1L is an essential regulator in the progression of malignancies. In addition, we found that the expression of GPD1L was much lower in LUAD tissues when compared with nontumor specimens. According to the findings of ROC tests, GPD1L was able to effectively identify LUAD specimens from nontumor samples with an AUC value of 0.828 (95% confidence interval: 0.793 to 0.863). On the basis of the clinical study, a low expression of GPD1L was clearly related with both the N stage and the clinical stage. Moreover, based on the findings of a Kaplan-Meier survival study, elevated GPD1L expression was a strong indicator of considerably improved overall survival (OS) and disease-specific survival (DSS). GPD1L expression and clinical stages were found to be independent prognostic indicators for overall survival and disease-free survival in LUAD patients, according to multivariate analyses. Based on multivariate analysis, the C-indexes and calibration plots of the nomogram demonstrated an effective prediction performance for LUAD patients. Besides, the expression of GPD1L was positively related to mast cells, eosinophils, Tcm, TFH, iDC, DC, and macrophages, while negatively associated with Th2 cells, NK CD56dim cells, Tgd, Treg, and neutrophils. Finally, qRT-PCR was able to demonstrate that GPD1L had a significant amount of expression in LUAD. Additionally, according to the results of functional tests, overexpression of GPD1L had a significant inhibiting effect on the proliferation of LUAD cells. In general, the results of our study suggested that GPD1L had the potential to serve as a diagnostic and prognostic marker for LUAD.
supplementary figure legend from The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1)
Authors: Vena Francesca , Li Causi Eleonora , Rodriguez-Justo Manuel , Goodstal Samantha , Hagemann Thorsten , Hartley John A. , Hochhauser Daniel
Published: April 2023

supplementary figure legend
Figure S3 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Authors: Coghill Anna E. , Pfeiffer Ruth M. , Proietti Carla , Hsu Wan-Lun , Chien Yin-Chu , Lekieffre Lea , Krause Lutz , Teng Andy , Pablo Jocelyn , Yu Kelly J. , Lou Pei-Jen , Wang Cheng-Ping , Liu Zhiwei , Chen Chien-Jen , Middeldorp Jaap , Mulvenna Jason , Bethony Jeff , Hildesheim Allan , Doolan Denise L.
Published: April 2023

Supplemental Figure 3
Figure S3.A from The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1)
Authors: Vena Francesca , Li Causi Eleonora , Rodriguez-Justo Manuel , Goodstal Samantha , Hagemann Thorsten , Hartley John A. , Hochhauser Daniel
Published: April 2023

Figure S3.A. MG132 impairs RRM1 downregulation induced by pimartib in PANC-1 cells.
Figure S2.B from The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1)
Authors: Vena Francesca , Li Causi Eleonora , Rodriguez-Justo Manuel , Goodstal Samantha , Hagemann Thorsten , Hartley John A. , Hochhauser Daniel
Published: April 2023

Figure S2.B. RRM1 expression is not modulated by EGFR signalling.
Supplementary Methods, Figure 1, Table 1 from A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors
Authors: Chiorean Elena Gabriela , LoRusso Patricia , Strother Robert Matthew , Diamond Jennifer R. , Younger Anne , Messersmith Wells A. , Adriaens Lieve , Liu Liming , Kao Richard J. , DiCioccio Albert Thomas , Kostic Ana , Leek Russell , Harris Adrian , Jimeno Antonio
Published: April 2023

Supplementary Methods, Figure 1, Table 1. Supplementary Figure 1: Vascular expression of Dll4 versus CD31 in archive tumor tissue biopsies -Supplementary Table 1: Correlations between VEGFR-2 VQ and Notch1, Notch3, Dll4 Expression in Archive Samples
Figure S1.A from The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1)
Authors: Vena Francesca , Li Causi Eleonora , Rodriguez-Justo Manuel , Goodstal Samantha , Hagemann Thorsten , Hartley John A. , Hochhauser Daniel
Published: April 2023

Figure S1.A. Effect of pimasertib followed by short treatment with gemcitabine in vitro.
Complete supplemental Figures from Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein–Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression
Authors: Jones Richard J. , Iempridee Tawin , Wang Xiaobin , Lee Hans C. , Mertz Janet E. , Kenney Shannon C. , Lin Heather C. , Baladandayuthapani Veerabhadran , Dawson Christopher W. , Shah Jatin J. , Weber Donna M. , Orlowski Robert Z.
Published: April 2023

1.Contains schematic of a LEN, THAL DEX dosing schedule. 2. EBV viral load in patients who received LEN, THAL, DEX with VTX or no VTX.
Combination Indices (CI) of LEN, THAL or POM in combination with GCV at 7 days. from Lenalidomide, Thalidomide, and Pomalidomide Reactivate the Epstein–Barr Virus Lytic Cycle through Phosphoinositide 3-Kinase Signaling and Ikaros Expression
Authors: Jones Richard J. , Iempridee Tawin , Wang Xiaobin , Lee Hans C. , Mertz Janet E. , Kenney Shannon C. , Lin Heather C. , Baladandayuthapani Veerabhadran , Dawson Christopher W. , Shah Jatin J. , Weber Donna M. , Orlowski Robert Z.
Published: April 2023

Combination indices of LEN, THAL or POM in combination with GCV.
Supplementary Figure S3 from Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer
Authors: Cristóbal Ion , Rincón Raúl , Manso Rebeca , Caramés Cristina , Zazo Sandra , Madoz-Gúrpide Juan , Rojo Federico , García-Foncillas Jesús
Published: April 2023

Supplementary Figure S3. Effect of SET silencing in the sensitivity of CRC cells to 5-FU alone or combined with oxaliplatin.
Supplementary Figure S2 from Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer
Authors: Cristóbal Ion , Rincón Raúl , Manso Rebeca , Caramés Cristina , Zazo Sandra , Madoz-Gúrpide Juan , Rojo Federico , García-Foncillas Jesús
Published: April 2023

Supplementary Figure S2. SET modulation in CRC cells ectopically expressing PP2A.
Supplementary tables S1-S10 from Loss-of-Function Mutations in Calcitonin Receptor (CALCR) Identify Highly Aggressive Glioblastoma with Poor Outcome
Authors: Pal Jagriti , Patil Vikas , Kumar Anupam , Kaur Kavneet , Sarkar Chitra , Somasundaram Kumaravel
Published: April 2023

Supplementary tables S1-S10
Supplemental Figure 3 from SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
Authors: Zhang Xiaotun , Coleman Ilsa M. , Brown Lisha G. , True Lawrence D. , Kollath Lori , Lucas Jared M. , Lam Hung-Ming , Dumpit Ruth , Corey Eva , Chéry Lisly , Lakely Bryce , Higano Celestia S. , Montgomery Bruce , Roudier Martine , Lange Paul H. , Nelson Peter S. , Vessella Robert L. , Morrissey Colm
Published: April 2023

(A) Hypothetical interactions between NE-associated transcription factors upregulated in CHGA+/SYP+/AR- tumors that promote the AR- NE phenotype. (B) A Venn diagram comparing genes with a SAM score >2.5 between CHGA- and CHGA+/SYP- metastases and CHGA+/SYP+/AR- metastases (598 genes) or CHGA+/SYP+/AR+ metastases (61 genes). Thirty-seven genes with a SAM score >2.5 were common to CHGA+/SYP+/AR- and CHGA+/SYP+/AR+ metastases.
Supplementary Table S1 from A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer
Authors: Pandit-Taskar Neeta , O'Donoghue Joseph A. , Durack Jeremy C. , Lyashchenko Serge K. , Cheal Sarah M. , Beylergil Volkan , Lefkowitz Robert A. , Carrasquillo Jorge A. , Martinez Danny F. , Fung Alex Mak , Solomon Stephen B. , Gönen Mithat , Heller Glenn , Loda Massimo , Nanus David M. , Tagawa Scott T. , Feldman Jarett L. , Osborne Joseph R. , Lewis Jason S. , Reuter Victor E. , Weber Wolfgang A. , Bander Neil H. , Scher Howard I. , Larson Steven M. , Morris Michael J.
Published: April 2023

Supplementary Table S1. Patient demographics
Supplementary Table S1 from Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer
Authors: Gyanchandani Rekha , Lin Yan , Lin Hui-Min , Cooper Kristine , Normolle Daniel P. , Brufsky Adam , Fastuca Michael , Crosson Whitney , Oesterreich Steffi , Davidson Nancy E. , Bhargava Rohit , Dabbs David J. , Lee Adrian V.
Published: April 2023

Clinical characteristics, treatment, and outcome data for all patients
Supplementary Information from PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia
Authors: Zhou Jingfeng , Nie Danian , Li Juan , Du Xin , Lu Yuhong , Li Yangqiu , Liu Chang , Dai Wei , Wang Yun , Jin Yanli , Pan Jingxuan
Published: April 2023

Supplementary Materialsï¼ŒMethods and Figure Legends
Supplemental Table 1 from Phase I Study of Fenretinide Delivered Intravenously in Patients with Relapsed or Refractory Hematologic Malignancies: A California Cancer Consortium Trial
Authors: Mohrbacher Ann M. , Yang Allen S. , Groshen Susan , Kummar Shivaani , Gutierrez Martin E. , Kang Min H. , Tsao-Wei Denice , Reynolds C. Patrick , Newman Edward M. , Maurer Barry J.
Published: April 2023

Dose Escalation Schedule
Supplementary Methods from Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab
Authors: Weide Benjamin , Martens Alexander , Hassel Jessica C. , Berking Carola , Postow Michael A. , Bisschop Kees , Simeone Ester , Mangana Johanna , Schilling Bastian , Di Giacomo Anna Maria , Brenner Nicole , Kähler Katharina , Heinzerling Lucie , Gutzmer Ralf , Bender Armin , Gebhardt Christoffer , Romano Emanuela , Meier Friedegund , Martus Peter , Maio Michele , Blank Christian , Schadendorf Dirk , Dummer Reinhard , Ascierto Paolo A. , Hospers Geke , Garbe Claus , Wolchok Jedd D.
Published: April 2023

Algorithm for cut-off point definition
Supplementary Table S1: Tissue types, samples, and signatures from Mutational Signatures in Breast Cancer: The Problem at the DNA Level
Authors: Nik-Zainal Serena , Morganella Sandro
Published: April 2023

Supplementary Table S1: Tissue types, samples, and signatures
Supplementary Figure S4: ICGC 30 consensus from Mutational Signatures in Breast Cancer: The Problem at the DNA Level
Authors: Nik-Zainal Serena , Morganella Sandro
Published: April 2023

Supplementary Figure S4: ICGC 30 consensus
Supplementary Figure S3. FASN and EGFR mRNA levels. from Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer
Authors: Giró-Perafita Ariadna , Palomeras Sònia , Lum David H. , Blancafort Adriana , Viñas Gemma , Oliveras Glòria , Pérez-Bueno Ferran , Sarrats Ariadna , Welm Alana L. , Puig Teresa
Published: April 2023

(A) 231 and 231DXR and (B) HCC and HCCDXR. mRNA levels were obtained by Real-Time PCR and normalized against the β-actin gene. Results shown are mean {plus minus} SEM from 3 independent experiments.
Supplement from PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer
Authors: Yearley Jennifer H. , Gibson Christopher , Yu Ni , Moon Christina , Murphy Erin , Juco Jonathan , Lunceford Jared , Cheng Jonathan , Chow Laura Q.M. , Seiwert Tanguy Y. , Handa Masahisa , Tomassini Joanne E. , McClanahan Terrill
Published: April 2023

Supplementary Figures S1-S5
Table S4 from Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34+ Cells in Healthy Volunteers
Authors: Abraham Michal , Pereg Yaron , Bulvik Baruch , Klein Shiri , Mishalian Inbal , Wald Hana , Eizenberg Orly , Beider Katia , Nagler Arnon , Golan Rottem , Vainstein Abi , Aharon Arnon , Galun Eithan , Caraco Yoseph , Or Reuven , Peled Amnon
Published: April 2023

Supplemented Table 4A: Absolut number of different subsets of hematopoietic stem cells Supplemented Table 4B: Percentages of different subpopulations of BL-8040 mobilized cells as compared to G-CSF mobilized cells
Table S2 from Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34+ Cells in Healthy Volunteers
Authors: Abraham Michal , Pereg Yaron , Bulvik Baruch , Klein Shiri , Mishalian Inbal , Wald Hana , Eizenberg Orly , Beider Katia , Nagler Arnon , Golan Rottem , Vainstein Abi , Aharon Arnon , Galun Eithan , Caraco Yoseph , Or Reuven , Peled Amnon
Published: April 2023

Table S2A: Summary Statistics of Pharmacokinetic Parameters of BL-8040 after Day 1 (First Dose) in Healthy Volunteers. Table S2B: Summary Statistics of Pharmacokinetic Parameters of BL-8040 after Day 2 (Second Dose) in Healthy Volunteers
Supplementary Figure 4 from Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho
Authors: Behera Reeti , Kaur Amanpreet , Webster Marie R. , Kim Suyeon , Ndoye Abibatou , Kugel Curtis H. , Alicea Gretchen M. , Wang Joshua , Ghosh Kanad , Cheng Phil , Lisanti Sofia , Marchbank Katie , Dang Vanessa , Levesque Mitchell , Dummer Reinhard , Xu Xiaowei , Herlyn Meenhard , Aplin Andrew E. , Roesch Alexander , Caino Cecilia , Altieri Dario C. , Weeraratna Ashani T.
Published: April 2023

Supplementary Figure 4
Supplementary Table S2 from Intravesical Bacillus Calmette Guerin Combined with a Cancer Vaccine Increases Local T-Cell Responses in Non-muscle–Invasive Bladder Cancer Patients
Authors: Derré Laurent , Cesson Valérie , Lucca Ilaria , Cerantola Yannick , Valerio Massimo , Fritschi Urs , Vlamopoulos Yannis , Burruni Rodolfo , Legris Anne-Sophie , Dartiguenave Florence , Gharbi Dalila , Martin Virginie , Vaucher Laurent , Speiser Daniel E. , Romero Pedro , Jichlinski Patrice , Nardelli-Haefliger Denise
Published: April 2023

Cancer-vaccine and BCG administration schedules
Supplementary Table S1 from Intravesical Bacillus Calmette Guerin Combined with a Cancer Vaccine Increases Local T-Cell Responses in Non-muscle–Invasive Bladder Cancer Patients
Authors: Derré Laurent , Cesson Valérie , Lucca Ilaria , Cerantola Yannick , Valerio Massimo , Fritschi Urs , Vlamopoulos Yannis , Burruni Rodolfo , Legris Anne-Sophie , Dartiguenave Florence , Gharbi Dalila , Martin Virginie , Vaucher Laurent , Speiser Daniel E. , Romero Pedro , Jichlinski Patrice , Nardelli-Haefliger Denise
Published: April 2023

Patients characteristics
Supplementary Table 1 from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study
Authors: Connolly Roisin M. , Li Huili , Jankowitz Rachel C. , Zhang Zhe , Rudek Michelle A. , Jeter Stacie C. , Slater Shannon A. , Powers Penny , Wolff Antonio C. , Fetting John H. , Brufsky Adam , Piekarz Richard , Ahuja Nita , Laird Peter W. , Shen Hui , Weisenberger Daniel J. , Cope Leslie , Herman James G. , Somlo George , Garcia Agustin A. , Jones Peter A. , Baylin Stephen B. , Davidson Nancy E. , Zahnow Cynthia A. , Stearns Vered
Published: April 2023

Patient characteristics (optional continuation phase)
Supplementary Figure 2 from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study
Authors: Connolly Roisin M. , Li Huili , Jankowitz Rachel C. , Zhang Zhe , Rudek Michelle A. , Jeter Stacie C. , Slater Shannon A. , Powers Penny , Wolff Antonio C. , Fetting John H. , Brufsky Adam , Piekarz Richard , Ahuja Nita , Laird Peter W. , Shen Hui , Weisenberger Daniel J. , Cope Leslie , Herman James G. , Somlo George , Garcia Agustin A. , Jones Peter A. , Baylin Stephen B. , Davidson Nancy E. , Zahnow Cynthia A. , Stearns Vered
Published: April 2023

Cellular tumor purity for biopsies is greater than 70%. Tumor purity from biopsies was analyzed with the Estimate Package from Bioconductor using R language. The majority (85%) of biopsies have an estimated cellular purity of over 70%, with small differences observed between pre and post-tx biopsies. Patient 17 had both 8-week and 6-months post-tx biopsies. Tx: therapy.
Supplementary Information from A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Authors: Liu Caifeng , Zhang Yunjian , Lim Sharon , Hosaka Kayoko , Yang Yunlong , Pavlova Tatiana , Alkasalias Twana , Hartman Johan , Jensen Lasse , Xing Xiaoming , Wang Xinsheng , Lu Yongtian , Nie Guohui , Cao Yihai
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 1 from Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study
Authors: Connolly Roisin M. , Li Huili , Jankowitz Rachel C. , Zhang Zhe , Rudek Michelle A. , Jeter Stacie C. , Slater Shannon A. , Powers Penny , Wolff Antonio C. , Fetting John H. , Brufsky Adam , Piekarz Richard , Ahuja Nita , Laird Peter W. , Shen Hui , Weisenberger Daniel J. , Cope Leslie , Herman James G. , Somlo George , Garcia Agustin A. , Jones Peter A. , Baylin Stephen B. , Davidson Nancy E. , Zahnow Cynthia A. , Stearns Vered
Published: April 2023

Kaplan-Meier curves for survival after disease progression among women with advanced hormone-resistant breast cancer by optional continuation (blue curve) or event monitoring (red curve). The 95% confidence limits are shaded; Tick marks indicate censored data.
Figure S5 from A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Authors: Liu Caifeng , Zhang Yunjian , Lim Sharon , Hosaka Kayoko , Yang Yunlong , Pavlova Tatiana , Alkasalias Twana , Hartman Johan , Jensen Lasse , Xing Xiaoming , Wang Xinsheng , Lu Yongtian , Nie Guohui , Cao Yihai
Published: April 2023

Gene expression in PDGF-BB stimulated fibroblasts
Figure S4 from A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Authors: Liu Caifeng , Zhang Yunjian , Lim Sharon , Hosaka Kayoko , Yang Yunlong , Pavlova Tatiana , Alkasalias Twana , Hartman Johan , Jensen Lasse , Xing Xiaoming , Wang Xinsheng , Lu Yongtian , Nie Guohui , Cao Yihai
Published: April 2023

Growth factor-stimulated fibroblasts promote NSCLC metastasis
Figure S3 from A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Authors: Liu Caifeng , Zhang Yunjian , Lim Sharon , Hosaka Kayoko , Yang Yunlong , Pavlova Tatiana , Alkasalias Twana , Hartman Johan , Jensen Lasse , Xing Xiaoming , Wang Xinsheng , Lu Yongtian , Nie Guohui , Cao Yihai
Published: April 2023

Mouse CAFs promote CRC metastasis
Supplementary Table S3 from Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts
Authors: Stelloo Ellen , Nout Remi A. , Osse Elisabeth M. , Jürgenliemk-Schulz Ina J. , Jobsen Jan J. , Lutgens Ludy C. , van der Steen-Banasik Elzbieta M. , Nijman Hans W. , Putter Hein , Bosse Tjalling , Creutzberg Carien L. , Smit Vincent T.H.B.M.
Published: April 2023

Clinicopathological characteristics, additional mutations and protein expression alterations in tumours with multiple classifying alterations.
Supplementary Table S2 from Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts
Authors: Stelloo Ellen , Nout Remi A. , Osse Elisabeth M. , Jürgenliemk-Schulz Ina J. , Jobsen Jan J. , Lutgens Ludy C. , van der Steen-Banasik Elzbieta M. , Nijman Hans W. , Putter Hein , Bosse Tjalling , Creutzberg Carien L. , Smit Vincent T.H.B.M.
Published: April 2023

Hotspot mutation frequency according to the four molecular subgroups in early-stage endometrial cancer (n=834).
Supplementary table 1, Supplementary table 2 from Time-Degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among Hepatitis C Virus Patients: A Model for Prioritization of Treatment
Authors: Yu Ming-Lung , Huang Chung-Feng , Yeh Ming-Lun , Tsai Pei-Chien , Huang Ching-I. , Hsieh Meng-Hsuan , Hsieh Ming-Yen , Lin Zu-Yau , Chen Shinn-Cherng , Huang Jee-Fu , Dai Chia-Yen , Chuang Wan-Long
Published: April 2023

Supplementary table 1. Risk of HCC in patients with different age groups and treatment responses Supplementary table 2. Risk of HCC in patients with different fibrotic stages and treatment responses
Supplementary figure 1 from Time-Degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among Hepatitis C Virus Patients: A Model for Prioritization of Treatment
Authors: Yu Ming-Lung , Huang Chung-Feng , Yeh Ming-Lun , Tsai Pei-Chien , Huang Ching-I. , Hsieh Meng-Hsuan , Hsieh Ming-Yen , Lin Zu-Yau , Chen Shinn-Cherng , Huang Jee-Fu , Dai Chia-Yen , Chuang Wan-Long
Published: April 2023

Risk of HCC in patients with or without SVR stratified by different age groups
Supplementary Data from PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Authors: Sunshine Joel C. , Nguyen Peter L. , Kaunitz Genevieve J. , Cottrell Tricia R. , Berry Sneha , Esandrio Jessica , Xu Haiying , Ogurtsova Aleksandra , Bleich Karen B. , Cornish Toby C. , Lipson Evan J. , Anders Robert A. , Taube Janis M.
Published: April 2023

Supplemental Figures S1 Figure S2, Figure S3 and Table S1 and Table S2
Supplemental Figure 1B from Circulating Tumor Cells Expressing Markers of Tumor-Initiating Cells Predict Poor Survival and Cancer Recurrence in Patients with Pancreatic Ductal Adenocarcinoma
Authors: Poruk Katherine E. , Blackford Amanda L. , Weiss Matthew J. , Cameron John L. , He Jin , Goggins Michael , Rasheed Zeshaan A. , Wolfgang Christopher L. , Wood Laura D.
Published: April 2023

Staining of primary tumors by immunohistochemistry demonstrating (B) weak staining in ALDH
Supplementary Table 1 from A Multi-Institution Phase I Trial of Ruxolitinib in Patients with Chronic Myelomonocytic Leukemia (CMML)
Authors: Padron Eric , Dezern Amy , Andrade-Campos Marcio , Vaddi Kris , Scherle Peggy , Zhang Qing , Ma Yan , Balasis Maria E. , Tinsley Sara , Ramadan Hanadi , Zimmerman Cassandra , Steensma David P. , Roboz Gail J. , Lancet Jeffrey E. , List Alan F. , Sekeres Mikkael A. , Komrokji Rami S.
Published: April 2023

Table summarizing cohort escalation rules for this clinical trial.
Supplementary Information from Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma
Authors: Hart Lori S. , Rader JulieAnn , Raman Pichai , Batra Vandana , Russell Mike R. , Tsang Matthew , Gagliardi Maria , Chen Lucy , Martinez Daniel , Li Yimei , Wood Andrew , Kim Sunkyu , Parasuraman Sudha , Delach Scott , Cole Kristina A. , Krupa Shiva , Boehm Markus , Peters Malte , Caponigro Giordano , Maris John M.
Published: April 2023

This document contains Supplementary information, including materials and methods as well as Figure Legends for the Supplementary Figures.
Supplementary Figures from Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma
Authors: Hart Lori S. , Rader JulieAnn , Raman Pichai , Batra Vandana , Russell Mike R. , Tsang Matthew , Gagliardi Maria , Chen Lucy , Martinez Daniel , Li Yimei , Wood Andrew , Kim Sunkyu , Parasuraman Sudha , Delach Scott , Cole Kristina A. , Krupa Shiva , Boehm Markus , Peters Malte , Caponigro Giordano , Maris John M.
Published: April 2023

Supplementary Figure S1. Neuroblastoma cell lines are sensitive to binimetinib. Supplementary Figure S2. Gene expression profiling of human neuroblastoma cell lines with regards to relative sensitivity to MEK1/2 and CDK4/6 inhibition Supplementary Figure S3. Combined MEK and CDK4/6 inhibition does not induce significant levels of apoptosis or senescence. Supplementary Figure S4. G1 arrest induced by MEK1/2 and CDK4/6 inhibition is reversible. Supplementary Figure S5. Gene expression profiling of human neuroblastoma cell lines with regards to the synergy observed from combined binimetinib-ribociclib treatment. Figure S6. Neuroblastoma xenografts are sensitive to combined binimetinib-ribociclib treatment.
Online Supplementary Tables from Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma
Authors: Hart Lori S. , Rader JulieAnn , Raman Pichai , Batra Vandana , Russell Mike R. , Tsang Matthew , Gagliardi Maria , Chen Lucy , Martinez Daniel , Li Yimei , Wood Andrew , Kim Sunkyu , Parasuraman Sudha , Delach Scott , Cole Kristina A. , Krupa Shiva , Boehm Markus , Peters Malte , Caponigro Giordano , Maris John M.
Published: April 2023

Table S1. Specific mutations of genes listed in Table 1. Table S2. Foundation Medicine sequencing calls of cancer-specific gene panel. Table S3. Gene lists corresponding to microarray analysis described in Figures 1A and 1B: (A) binimetinib and (B) ribociclib. Significant genes (in bold type) are defined as having an adjusted p-value of 0.25 or less.
SFigure 6 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival
Authors: Müller-Greven Gaëlle , Carlin Cathleen R. , Burgett Monica E. , Ahluwalia Manmeet S. , Lauko Adam , Nowacki Amy S. , Herting Cameron J. , Qadan Maha A. , Bredel Markus , Toms Steven A. , Lathia Justin D. , Hambardzumyan Dolores , Sarkaria Jann N. , Hamerlik Petra , Gladson Candece L.
Published: April 2023

Figure S6 shows bevacizumab treatment causes a reduction in phospho-VEGFR2 and downregulation of VEGF-A induces autophagy in CD133+ GBM cells.
Figure S7 from Enhanced Cancer Immunotherapy by Chimeric Antigen Receptor–Modified T Cells Engineered to Secrete Checkpoint Inhibitors
Authors: Li Si , Siriwon Natnaree , Zhang Xiaoyang , Yang Shuai , Jin Tao , He Feng , Kim Yu Jeong , Mac John , Lu Zhengfei , Wang Sijie , Han Xiaolu , Wang Pin
Published: April 2023

(A) The ratio of CD8+ versus CD4+ T cells before they were adoptively transferred into the mice. (B) The ratio of CD8+ versus CD4+ T cells from the mice treated with CAR19.Î±PD1 T cells (n=3, mean {plus minus} SEM; **P < 0.01). (C) The expression of IFN-Î³ in the sera was measured by ELISA.
Figure S5 from Enhanced Cancer Immunotherapy by Chimeric Antigen Receptor–Modified T Cells Engineered to Secrete Checkpoint Inhibitors
Authors: Li Si , Siriwon Natnaree , Zhang Xiaoyang , Yang Shuai , Jin Tao , He Feng , Kim Yu Jeong , Mac John , Lu Zhengfei , Wang Sijie , Han Xiaolu , Wang Pin
Published: April 2023

The representative gating schemes and plots for CD8+PD-L1+ T cells (A) and CD8+LAG-3+ and CD8+TIM-3+ T cells (B) after antigen-specific stimulation for 24 hours.
Supplementary Table 1 from PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer
Authors: Xu Jian-Ming , Wang Yan , Wang You-Liang , Liu Tao , Ni Ming , Li Man-Sheng , Lin Li , Ge Fei-Jiao , Gong Chun , Gu Jun-Yan , Jia Ru , Wang He-Fei , Chen Yu-Ling , Liu Rong-Rui , Zhao Chuan-Hua , Tan Zhao-Li , Jin Yang , Zhu Yun-Ping , Ogino Shuji , Qian Zhi-Rong
Published: April 2023

Clinical information of validation cohort