bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Insight to Identify Potential Inhibitors of BUB1B from Mushroom Bioactive Compounds to Prevent Breast Cancer Metastasis
Authors: Mishra Divya , Mishra Ashish , Rai Sachchida nand , Singh Santosh kumar , Vamanu Emanuel , Singh Mohan P.
Published: July 2023

Background: Breast cancer is one of the most common types of cancer among women worldwide, and its metastasis is a significant cause of mortality. Therefore, identifying potential inhibitors of proteins involved in breast cancer metastasis is crucial for developing effective therapies. BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is a key regulator of mitotic checkpoint control, which ensures the proper segregation of chromosomes during cell division. Dysregulation of BUB1B has been linked to a variety of human diseases, including breast cancer. Overexpression of BUB1B has been observed in various cancer types, and its inhibition has been shown to induce cancer cell death. Additionally, BUB1B inhibition has been suggested as a potential strategy for overcoming resistance to chemotherapy and radiation therapy. Given the importance of BUB1B in regulating cell division and its potential as a therapeutic target, the development of BUB1B inhibitors has been the focus of intense research efforts. Despite these efforts, few small molecule inhibitors of BUB1B have been identified, highlighting the need for further research in this area. In this study, the authors aimed to identify potential inhibitors of BUB1B from mushroom bioactive compounds using computational methods, which could ultimately lead to the development of new treatments for breast cancer metastasis. Methods: This study has incorporated 70 bioactive compounds (handpicked through literature mining) of distinct mushrooms that were considered and explored to identify a suitable drug candidate. Their absorption, distribution, metabolism and excretion (ADME) properties were obtained to predict the drug-likeness of these 70 mushroom compounds based on Lipinski’s rule of 5 (RO5). Screening these bioactive compounds and subsequent molecular docking against BUB1B provided compounds with the best conformation-based binding affinity. The best two complexes, i.e., BUB1B-lepitaprocerin D and BUB1B-peptidoglycan, were subjected to molecular dynamic simulations. Both complexes were assessed for their affinity, stability, and flexibility in protein-ligand complex systems. Results: The molecular dynamic (MD) simulation studies revealed that lepitaprocerin D has an energetically favorable binding affinity with BUB1B. Results showed that the formation of a hydrogen bond between residues ASN123 and SER157, and lepitaprocerin D had strengthened the affinity of lepitaprocerin D with BUB1B. Conclusions: This study identified lepitaprocerin D as a potential and novel inhibitor for BUB1B that could be a plausible drug candidate for identifying and controlling the spread of breast cancer metastasis.
Omega-3 Polyunsaturated Fatty Acids and Their Anti-Oxidant, Anti-Inflammatory and Neuroprotective Effects in Diabetic Retinopathy: A Narrative Review
Authors: Fathima Sarah , Prokopiou Ekatherine , Georgiou Tassos
Published: July 2023

Diabetic retinopathy (DR) is a common microvascular complication of type 2 Diabetes Mellitus (T2DM) that can have vision-threatening consequences, particularly if it advances to the proliferative stage and is left untreated. Owing to the central role of hyperglycemia-induced oxidative stress, multiple anti-oxidants have been investigated for their therapeutic value. However, there is a lack of substantial data to support the use of any of the compounds tested so far. Omega-3 polyunsaturated fatty acids (PUFAs), namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have received much acclaim for their positive impact on cardiovascular health outcomes. The anti-oxidative, anti-inflammatory and neuroprotective properties of PUFAs also make them promising therapeutic and preventive agents for DR. The current evidence is derived mainly from in vitro and animal studies and provides some insight into the underlying mechanisms involved. These fatty acids are capable of direct anti-oxidative and anti-inflammatory effects. They also concomitantly promote intrinsic defense mechanisms and recovery, particularly of photoreceptor neurons. Hence, dietary supplementation with PUFAs, mainly from marine sources, can halt and reverse the retinal damage seen in DR. Furthermore, clinical trials have reported improved vision and quality of life in DR patients after supplementation. However, a major limitation of these trials is the use of nutraceutical formulations in which omega-3 PUFAs are combined with other anti-oxidant compounds, thereby preventing the evaluation of omega-3 as standalone treatment. Although the results of experimental studies to date have been promising, more clinical trials are required to determine the full extent of benefits in patients with DR.
Cannabidiol (CBD) with 4',7-Isoflavandiol (Equol) Efficacy is Greater than CBD or Equol Treatment Alone via Human Skin Gene Expression Analysis
Authors: Lephart Edwin D.
Published: July 2023

Background: While cannabidiol (CBD) and 4’,7-isoflavandiol (Equol) have been examined individually in various skin studies, the present investigation tested whether topically applied CBD with Equol may yield enhanced effects on human skin biomarkers. Methods: After 24 hours exposure human skin gene expression was measured by quantitative polymerase chain reaction-messenger ribonucleic acid (qPCR-mRNA) analysis across 9 functional skin categories covering 97 biomarkers. Results: In general, among the biomarkers analyzed the CBD with Equol treatment displayed greater efficacy compared to CBD only or the Equol treatment alone (e.g., 4 out 5 for anti-acne, 15 out of 17 for anti-aging [e.g., collagen, elastin, calcium binding protein A7, tissue inhibitor of matrix metalloproteinase 1 (TIMP 1), etc.], 19 out of 21 for anti-inflammatory (pain), 10 out of 11 for antioxidants to protect against oxidative stress, 6 out of 6 for circadian rhythm regulation for cell repair/restoration, 10 out of 15 for anti-pigmentation properties, 4 out of 5 for skin hydration, 6 out of 6 for tissue integrity, and 11 out of 12 for wound healing properties). Conclusions: CBD with Equol displayed synergistic effects that may be an effective topical treatment for dermatology and cosmetic applications to improve human skin health and reduce photo-aging.
The Relationship between Nursing Students' Fear of COVID-19 and General Self-Efficacy and Clinical Stress Levels
Authors: Zengin Aydın Leyla , Doğan Aysel
Published: July 2023

Aim: This study was conducted to determine the relationship between the fear of COVID-19 and self-efficacy of nursing students and their clinical stress levels.
Material and Methods: The study was conducted in a descriptive and cross-sectional type between July and August 2021 in first-year nursing students of a health sciences faculty of a university. The study was completed with 89 nursing students who agreed to participate without sample selection (91% of the population was reached). The research data was collected using the Student Introductory Information Form, the Fear of COVID-19 Scale, the General Self-Efficacy Scale, and the Clinical Stress Questionnaire.
Results: It was determined that the mean age of the students was 20.24±1.15 years, 59.6% were women, 43.8% had COVID-19, 60.7% had families with COVID-19, and 14.6% had lost due to COVID-19. The mean score of the students on the Fear of COVID-19 Scale was 24.83±5.87, and the total score of the General Self-Efficacy Scale was 63.91±11.18. The Clinical Stress Questionnaire total score was 31.19±7.8. While there was a positive and significant relationship between the total score of the Fear of COVID-19 Scale and the total score of the General Self-Efficacy Scale (p<0.05), no significant.
Conclusion: In this study, it was determined that first-year nursing students experienced high levels of fear of COVID-19, had high levels of general self-efficacy, and experienced low levels of stress in their first clinical practice experience.
New data on Philanthus Fabricius species (Hymenoptera: Spheciformes) from Kuwait with some biological observations
Authors: Marafi Mohammad A.J. , Ben Khedher Hassib , Mansoury Eiman
Published: July 2023

Based on literature and newly-collected material, we list a total of five species of the genus Philanthus Fabricius, 1790 (Apoidea) from Kuwait. The subspecies Philanthus coarctatus coarctatus Spinola, 1839, is recorded locally for the first time, while the species Philanthus
triangulum (Fabricius, 1767) has new governmental records. The two taxa are illustrated in detail by digital photos. We also provided field observations for P.coarctatus coarctatus and both global and local geographical distributions of all species.
The barkfly Trimerocaecilius becheti Meinander (Psocoptera: Pseudocaeciliidae) new to Britain
Authors: Dodd Scotty G. , Alexander K.N.A. , Lienhard Charles
Published: July 2023

The barkfly Trimerocaecilius becheti Meinander, 1978 (Psocoptera: Pseudocaeciliidae) is added to the British list and its origins discussed.
An illustrated key to Anthophoroides Cockerell & Cockerell, with the description of three new species (Hymenoptera: Apidae)
Authors: Engel Michael S.
Published: July 2023

Three new species of the cosmopolitan bee genus Anthophora Latreille are described and figured from North America, all of the subgenus Anthophoroides Cockerell & Cockerell and all based on a series of females and males. Anthophora (Anthophoroides)
buchmanni sp. n. from Arizona, USA and Sonora, Mexico; A. (A.) cinerula sp. n. from California, Nevada, Utah, and Arizona, USA; whileA. (A.) kellieae sp. n. is recorded from southern California and Arizona, USA and Baja California, Mexico. An illustrated
key is presented to the species of Anthophoroides.
Mô hình MTAM: Lý thuyết tiềm năng về hành vi của người dùng công nghệ
Authors: Duong Thi Minh Phuong
Published: July 2023

Qua sự phát triển của MTAM, có thể thấy Mindsponge không phải là một lý thuyết cạnh tranh, xung đột với các lý thuyết khác mà thay vào đó, nó là một lý thuyết hỗ trợ, bổ sung và cải tiến cho các lý thuyết đã tồn tại.
VCAM1 is differentially expressed in central nervous system metastasis.
Authors: Mamoor Shahan
Published: July 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer and lung cancer (1-3). We mined published RNA-sequencing and multiplexed gene expression data (4, 5), comparing primary and brain metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the CNS. We found that vascular cell adhesion molecule 1, encoded by VCAM1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Multiplexed gene expression data (5) revealed conserved differential expression of VCAM1 in CNS metastasis in patients with lung cancer. VCAM1 mRNA was present at decreased quantities in metastasis to the brain in humans with breast cancer. Expression of VCAM1 in primary tumors of the breast, however, was not correlated with patient survival outcomes. Modulation of VCAM1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with cancer of the lung and breast.
Passion-Oranges Syrup Production Gung Pinto Village Tanah Karo
Authors: Suprianto Suprianto
Published: July 2023

Syrup is a beverage product resulting from the production of a mixture of water and sugar at a content of not less than 65%, whether or not ingredients are in the form of food with or without food additives, which have received permission to use according to the regulations of the Food and Drug Supervisory Agency of the Republic of Indonesia. Fruit syrup is made from fresh fruit juice with sugar and the taste and aroma of the fruit. Fruits used in syrup production must have an attractive color, aroma and distinctive taste. Example the taste and aroma of passion fruit (Passiflora edulis S) and sweet orange (Citrus sinensis L). Sweet orange and passion fruit are used as a source of fruit syrup juice. Sweet oranges are widely grown in Indonesia, including North Sumatra, especially in Gung Pinto Village, Tanah Karo. During the main harvest, there is usually a decrease in the price of oranges so that farmers are reluctant to pick the fruit which has been the foundation of their lives. This problem triggers farmers to look for solutions so that their crops do not rot on the trees. Community Service is here to provide a solution by increasing the skills of the community to make Passion Fruit Syrup for the people in the village of Gung Pinto Tanah Karo. The service is carried out by training how to make Passion-Orange syrup by doing direct practice and evaluating the resulting product with a hedonic test. The results showed that the Passion-Orange syrup product showed very good color, taste, aroma and texture, and the public was very happy with the results of the Passion-Orange syrup product. The conclusion of the service shows that the syrup product produced is very good and the community is very happy with the results of the syrup product.
A scoping review on climate change education
Authors: Muccione Veruska , Ewen Tracy , Vaghefi Saeid Ashraf
Published: July 2023

Escalating climate impacts predicted in the past decades are now a reality almost everywhere on the planet, and the time-critical dimension of the climate crisis means that the coming years will be instrumental in securing a climate resilient future for generations to come. Education is central to promoting climate action, yet the role that climate change education plays in advancing climate awareness, action and advocacy, and helping to enhance resiliency for young generations and the public at large is poorly understood. Here, we provide a first-of-its kind mapping of the literature on climate change education to better understand topic relationships and spatial distribution, and highlight potential new avenues for research on climate education. Machine learning methods including semantic analysis, geoparsing and topic modeling are used to support our study. Topic modeling shows that climate change education is a very interdisciplinary field of research well embedded in key climate change research topics including climate change adaptation, disaster risks and education, mitigation and sustainability, with the bulk of the literature situated in social science research, followed by topics on agricultural and adaptation, and education topics including methodologies, paradigm shifts, and research methods. Central to climate change education is the methodological dimension of teaching and educating either through formal or informal methods. Topic clustering reveals that topics including energy, renewable energy, fossil fuel and emissions are visibly far from topics school, teacher and science. As expected, social research lies in the middle and overlaps at the periphery with most other topic clusters, except with topics of energy mitigation, disaster risk, and medical health. Through geoparsing, country mentions and case studies are largely skewed towards the English speaking countries and in particular the United States– though this is not always the case when we look at more specific topics. This study should stimulate more targeted research into the specific topics that have emerged. Our findings also call for a strong incentive for governments to react on funding for further research into climate change education, also stimulating a global exchange of ideas through support and incentives for open science. More broadly, climate change education should be compulsory at all levels of formal education, ensuring a comprehensive curriculum of all relevant topics.
The ‘White Male Effect’ in Perceptions of Risk of Dying from COVID-19
Authors: Luo Ekim , Schnall Simone
Published: July 2023

During the COVID-19 pandemic people had to gauge their personal health risks in order to decide which protective behaviors to adopt. We explored whether mortality risk perceptions varied by demographic background. Using data from a nationally representative U.S. survey, we analyzed bi-weekly mortality estimates of 8,339 individuals from April 1, 2020 to July 21, 2021. Consistent with a White Male Effect, White men estimated the risk of death to be lower than White women, non-White men, and non-White women. Furthermore, when linking those estimates to the actual risk of dying from COVID-19, as reflected in official fatality rates recorded by the U.S. Center for Disease Control and Prevention (CDC), White men were indeed less likely to die from the coronavirus than would be expected based on their proportion of the populations. In contrast, deaths in non-White men and non-White women were higher than would be expected. Thus, subjective risk perceptions tracked objective mortality risks. Because White men tend to disproportionally hold positions with high decision-making power, although biased risk estimates may be less likely to have negative consequences for themselves, they may be especially detrimental to those for whom such decisions are made.
Re-evaluating the role of partnership-related perceptions in women’s preferences for men with masculine face shapes
Authors: Dong Junzhi , Leger Kathlyne , Lee Anthony J , Rafiee Yasaman , Jones Benedict C , Shiramizu Victor Kenji Medeiros
Published: July 2023

Many researchers have proposed that women perceive men with masculine face shapes to be less suitable as parents and long-term partners than men with feminine face shapes, causing women to find masculine men more attractive for short-term than long-term relationships. However, recent work showing that results obtained using the type of experimentally manipulated stimuli that were employed in studies presenting evidence for these claims are not necessarily observed when natural (i.e., unmanipulated) face stimuli were used suggest that the evidence for these claims may need to be revaluated. Consequently, we tested for possible relationships between ratings of natural male faces for parenting- and relationship-related traits and shape masculinity (Study 1) and also tested whether women’s preferences for shape masculinity were stronger when natural male faces were rated for short-term relationships than when natural male faces were rated for long-term relationships (Studies 2 and 3). We saw no evidence for either of these predictions, instead finding that men with more attractive faces were perceived to be better parents and better long-term partners. Thus, our findings do not support the widely held view that masculine men are more attractive for short-term relationships because they are perceived to be unlikely to invest time and effort in their romantic partners and offspring. This research was supported by ESRC grant ES/X000249/1 awarded to BCJ and a University of Strathclyde Global Research Award to JD. For the purpose of Open Access, the authors have applied a Creative Commons Attribution (CC BY) to any Author Accepted Manuscript (AAM) version arising from this submission.
Complements and Competitors: The Co-functionality and Co-diffusion of Languages on a Collaborative Coding Platform
Authors: Sirianni Antonio , Morgan Jonathan , Zoller Nikolas , Rogers Kimberly B. , Schröder Tobias
Published: July 2023

The vast majority of research on the diffusion of innovations focuses on how one particular idea or technology spreads across a network of connected individuals, or a population more generally. Diffusive processes are typically considered either in isolation. We consider innovations themselves as nodes in a larger network, and look at how individual innovations can spread with or against one another in a larger community of potential adopters. Using a large publicly-available data set, custom-designed measurements, and network analysis methods, we present a temporal analysis of a set of technological innovations. Specifically, we examine how coding languages spread across users on GitHub, an online platform for collaborative coding. By looking at which languages co-appear in individual projects, we develop network based measurements of how frequently languages appear together in the same coding projects (functional cohesion), and how similar two languages are in terms of how often they co-appear with other languages in coding projects (functional equivalence). We also assess two types of diffusion, one form where users of one language become users of an additional language (complementary or 'piggybacking' diffusion), and another where users of one language abandon one language for another (competitive or 'cannibalistic' diffusion). Using MR-QAP Regression Techniques, we find strong evidence that functional cohesion positively predicts complementary diffusion. We also find some evidence that functional equivalence predicts competitive diffusion. More broadly, we find support for the idea that the networks of functional relationships between innovations is important for understanding diffusive processes.
Towards a theory of revolution
Authors: Paccione Peter
Published: July 2023

This is an essay on comparative constitutional history and comparative revolution. In it, I will consider the development of the rule of law as a phase of state building, paying particular attention to representative institutions. I will compare the constitutional histories of England, France, Russia, Germany and the United States from their origins to the point in each nation’s history which I consider the end of that country’s revolution. It is my thesis that all revolutions are about law and constitutional arrangements. Revolutions answer the question: Who makes law? Where in the state does the legislative authority reside? I hope to show that the outcome of a revolution, the constitutional arrangements that result from it, is largely determined by the system of government that existed before the revolution. That is, however much revolutionaries might want to make a clean break with the past and create a totally new political system, the ultimate revolutionary outcome will have some continuity with the prerevolutionary system.
Capturing the intangible: how can measurement frameworks reveal impact from collective efforts in global health?
Authors: Nugent Rachel , Krishnamurthy Sumithra Reddy , Ngongo Carrie , Peterson Kyle
Published: July 2023

This paper explores methods used for measuring the impact of Access Accelerated. Using the example of Access Accelerated, we hope to identify potential impacts that may commonly result from collective action initiatives but that are overlooked by established measurement frameworks. Specifically, we develop the idea of “connective tissue,” an aspect of collective action that involves trust, social capital, and strong communication and can build a path to sustainability for partnerships involving the private sector.
Metabolic politics: Industrial relations as if nature mattered
Authors: Schaupp Simon
Published: July 2023

Work is at the center of the social metabolism with nature. This means that industrial relations (IR) are always also environmental politics. This article reviews core contributions to IR literature, showing that they do not systematically address this role of nature and separate the politics of work from their ecological basis. Against this backdrop, the article develops an interdisciplinary approach, combining IR studies with geographical as well as historical perspectives. Drawing on these fields, it presents the concept of metabolic politics in which nature is an autonomous party of IR. This approach allows analysis to take into account systematically the effects of IR on nonhuman nature as well as nature's own shaping of IR. Such an interdisciplinary approach is necessary to understand the entanglement of IR with climate change and the broader ecological crisis.
Weibull-H-NHE distribution with properties and applications on COVID-19 dataset
Authors: Sah Telee Lal Babu
Published: July 2023

A new three parameters univariate continuous distribution called Weibull-H-NHE distribution on COVID-19 data with Properties and Applications on COVID-19 data using Weibull-Hclass of distribution is introduced here. Some major properties of model with application on covid-19 data are presented in study. Different curves like probability density, hazard rate, and empirical distribution etc. are included in the study. Parameters are estimated by using method of least square. Model validation is tested by calculating different information criteria values as well as using Q-Q and P-P plots. The applicability of the model is tested on three sets of real data sets. Model application is checked by considering their real data set. All the calculations are done using the R language programming.
Fisiopatologia da COVID-19: Características da Resposta Imune de Crianças e Adultos.
Authors: Placco Bezerra Giovanna , Nunes Feitosa Thais , Correia Ternes Simone , Gibotti Adriana , Rossi de Almeida Flávio , Rossi de Almeida Vitor
Published: July 2023

Objetivo: apresentar a fisiopatologia da COVID-19 e os principais fatores que diferenciam o espectro da doença e resposta imune entre a faixa etária pediátrica e adulta. Revisão de literatura: Estudo exploratório bibliográfico narrativo realizado nas plataformas digitais PubMed, LILACS e Scielo, abrangendo publicações dentro do período de 2016 a 2021, tendo sido selecionado uma amostra de 18 artigos que abordam aspectos como estrutura e interação do vírus com humanos bem como sua replicação, principais diferenças nas características clínicas da COVID-19 na criança e no adulto e resposta imune. Conclusão: Foi possível elucidar os fatores que interferem na suscetibilidade da doença por COVID-19 e na resposta imune diferente entre crianças e adultos.
HARDWARE IMPLEMENTATION OF THE AUTOMATED INFORMATION COLLECTION SYSTEM FROM THE ELECTRICAL SUBSTATION 35/10 KV
Authors:   Donetsk National Technical University, Stupak M. , Potsepaiev V. ,   Donetsk National Technical University, Hryhorenko D. ,   Donetsk National Technical University
Published: July 2023

Purpose. Increasing connectivity and, as a result, reducing the time of receiving telemetry information on the distribution network section by means of the development of a hardware complex for monitoring and information transmission. Methodology. The research was carried out on the basis of system and elemental-structural approaches with elements of simulation modeling, programming and analytical calculations. Results. The results of the work are applied. Within the framework of the conducted research of the subject area, it has been suggested to use information and communication technologies to increase the level of operational response to emergency situations during the operation of electric transformer step-down substations. The parameters of the short-circuit current protection system have been calculated for the substation, based on the values of which a protection device with communication interface buses has been selected, which allow applying the approach of the Internet of Things, the Industrial Internet of Things, and the Internet of Energy for the subsequent construction of an automated information system. Hardware synthesis, selected means of automation and the given schemes allow further implementation of a full-fledged system of monitoring and control of the transformer substation. Scientific novelty. The concept of a universal system of information collection and transmission for distribution power systems has been proposed at the level of technical implementation. Practical significance. The paper offers a hardware data collection and transmission system that can be used in power systems for connection and telemetry of relay protection devices.
DEVELOPMENT THE ELECTRONIC UNIT FOR METAL INCLUSIONS IDENTIFICATION SUBSYSTEM IN RAW MATERIALS ON CONVEYOR BELT WITH AUTOMATIC DETERMINATION OF THEIR COORDINATES
Authors:   National Technical University of Oil and Gas, Zamikhovskyi L. , Striletskyi Yu. ,   National Technical University of Oil and Gas, Nykolaichuk M. ,   National Technical University of Oil and Gas, Levytskyi I. ,   National Technical University of Oil and Gas
Published: July 2023

Purpose. Ensuring reliability and efficiency manufacturing ceramic products technological process by integrating into it the subsystem for identifying metal inclusions in raw materials with automatic determination of their coordinates and dimensions for their further extraction. Methodology. Methods of circuit engineering, basics of system theory and automatic control, methods of electromagnetic circuits and digital signal processing are used, a comprehensive approach to the construction of a control system, mathematical methods of operations research are used as well. Results. The article provides a critical analysis of existing modern solutions for metal inclusions identification in loose raw materials for ceramic products manufacture during their movement on a conveyor belt. It was established that the presence of metal inclusions in raw materials inevitably leads to failures with subsequent breakdowns of technological equipment. The electronic unit for measuring and processing the signals from the receiving coils has been developed. The electronic unit for generating the excitation signal in the radiating coils has been carried out. Based on the proposed concept, the subsystem for detecting metal inclusions has been created, which is easily scaled to the width of the conveyor belt by selecting the number of measuring channels. The algorithm of signal processing for the receiving coils unit has been worked out, which allows implementing the synchronous signals forming, measurement, processing, and presentation of results. Scientific novelty. The identification subsystem structure of metal inclusions has been proposed, which is implemented on the parallax method of determining the position of the metal inclusion between the coils. Practical significance. The development and integration of the identification subsystem of metal inclusions into the structure of the automated control system of the raw material preparation process has been carried out, which includes the development of hardware and algorithmic support. As result of testing the identification subsystem of metal inclusions on a laboratory installation of conveyor line, it is possible to detect 89.8% ones of metal inclusions.
DFT Study of Intermolecular Proton Exchange with Some Derivatives of Benzoic Acids
Authors:   Karaganda University of the name of academician E.A. Buketov, Karaganda, Kazakhstan, Kurmanova Alfiya F. , Abilkanova Farida Zh. ,   Karaganda Industrial University, Temirtau, Kazakhstan, Pustolaikina Irina A. ,   Karaganda University of the name of academician E.A. Buketov, Karaganda, Kazakhstan, Nikolskiy Sergey N. ,   Karaganda University of the name of academician E.A. Buketov, Karaganda, Kazakhstan,   Altay State University, Barnaul, Russia
Published: July 2023

A theoretical study of proton transfer dynamics in complexes of some substituted benzoic acids with 3,6-di-tert-butyl-2-hydroxyphenoxyl (DTBPO) radical is presented. To elucidate the transfer mechanism, reaction pathways for various complexes of benzoic acid derivatives with DTBPO were modeled. The calculations were performed by the DFT method at the UB3LYP/6-31G+(d, p) level of theory using QST3, IRC procedures, in vacuum and toluene medium (PCM solvation model). Geometric and kinetic parameters of complexes with o-, p-, and m-isomers of nitrobenzoic and chlorobenzoic acids were calculated. Theoretically estimated activation barrier of 29-30 kJ/mol turned out to be approximately 30 % higher than the previously obtained experimental data. It was noted that in the case of o-isomers of aromatic acids the coplanarity of the transition state structure is violated, in contrast to the initial state. This leads to a change in the proton transfer mechanism. The dynamics of charge distribution, dipole moment and electrostatic potential in the studied complexes were analyzed. Based on the calculated data, it was shown that the studied intermolecular proton exchange process occurs throughout Hydrogen Atom Transfer (HAT), and not throughout Proton-Coupled Electron Transfer (PCET) mechanism
Professor Boris Filippovich Minaev: More than Half a Century of Scientific Activity and the 80th Anniversary of His Birth
Authors:   L.N. Gumilyov Eurasian National University, Astana, Kazakhstan, Irgibaeva Irina S. , Minaeva Valentina A. ,   Bohdan Khmelnytsky National University, Cherkasy, Ukraine
Published: July 2023

The article highlights the main periods of life, scientific and pedagogical activity of Boris Filippovich Minaev: Doctor of Chemical Sciences, Professor, Academician of the Academy of Sciences of the Higher School of Ukraine, Honored Worker of Science and Technology of Ukraine. The article reflects Minaev's great contribution to scientific research and informs about his achievements in the field of physical organic chemistry and molecular electronics. At the end of this article an overview of his most important scientific papers is presented.
Assessment of gene pool of black currant Federal Horticultural Center for Breeding, Agrotechnology and Nursery by resistance to currant gall mite in the Bryansk Region
Authors: Sazonov F. F. , Evdokimenko S. N. , Nebroi K. Yu. , Podgaetskiy M. A.
Published: July 2023

Since controlling currant gall mite (Cecidophyopsis ribis Westw.) is a challenging and ineffective task, developing genetic resistance to the pest is one of the main priorities in breeding programs for Ribes nigrum both in Russia and abroad. The task was assigned at the FSBSO “Federal Horticultural Center for Breeding, Agrotechnology and Nursery” to combine efficiently the positive economic and biological traits of previously developed varieties with resistance to phytophagous pests in hybrid progeny. The study evaluates the genetic collection and hybrid material of black currant for resistance to currant gall mite, as well as identifies the most promising parent pairs for mite-resistant progeny. The research objects included 107 varieties of various genetic origins, 30 of which were of foreign breeding. An assessment of the genetic collection carried out for ten years (since 2012) during the seasons of mass manifestation of the currant gall mite and reversion, is presented. Approximately 1,200 seedlings, planted in 2017, were studied. The methodologies for studying fruit, berry, and nut crops were used to assess the degree of incidence of the currant gall mite. The statistical processing of experimental results was performed using the Microsoft Excel program. As a result, the genetic sources and donors of resistance to the currant gall mite were identified (Barmaley, Dar Smolyaninovoi, Kipiana, Svityazyanka, Chernooka, Wonderful Moment, Ben Hope, Big Ben, etc.). The promising combinations of crosses were identified based on the yield of seedlings resistant to Cecidophyopsis ribis: Ben Hope×Kipiana, Ben Hope×Dar Smolyaninovoi, Kipiana×Dar Smolyaninovoi, Barmalei×Dar Smolyaninovoi, Ben Tirran×Kipiana, 9-28-1/02×Bryansk Agate, Dar Smolyaninovoi×33-27-1, 33-27-1×Kipiana. In the progeny of these parental forms, the selected forms were identified (3-63-01, 3-63-02, 9-197-3, 3-16-1, 7-28-01, 8-123-1), which combine resistance to the currant gall mite with large fruits and tolerance to fungal diseases.
УЧАСТЬ ІЛЛІ ШРАГА В УКРАЇНСЬКОМУ ГРОМАДСЬКО- ПРОСВІТНИЦЬКОМУ І ПОЛІТИКО-ПРАВОВОМУ РУСІ НА ПОЧАТКУХХ СТ.
Authors: Француз А.Й.  , Степаненко Н.В.
Published: July 2023

У статті здійснюється аналіз участі Іллі Шрага в українському і громадсько- просвітницькому і політико-правовому русі на початку ХХ ст. Зазначається, що державно-правові орієнтири Іллі Шрага базувалися навколо питань захисту прав рідної мови, особливостей правового статусу українського населення, земельного питання та інших важливих питань життєдіяльності суспільства. Особливо виразно державно-правові погляди Іллі Шрага простежуються у ході його активної участі в суспільно-політичних процесах, які відбувалися на території українських земель. Його участь в українському національному русі

сприяла об’єднанню свідомих діячів того часу на ниві розв’язання українського питання. Він намагався налагодити тісні контакти із західноукраїнськими діячами, спільна діяльність з якими дала можливість актуалізувати у суспільстві соборницькі ідеї, підняти на новий рівень питання української національної автономії. Водночас більш продуктивною стала співпраця в політичній, культурній, суспільний та просвітницькій діяльності. Наголошується, що І. Шраг плідно працював на ниві просвітництва, заснування фахових та культурно-освітніх громадських організацій, чим надавав суттєвого імпульсу суспільно-політичним перетворенням у різні часові проміжки розвитку українського суспільства. У процесі своєї діяльності він неодноразово був рупором українського населення щодо відстоювання ідей власної автономії та національної самоідентичності. Зауважується, що одним із важливих чинників розвитку українського суспільства І. Шраг вважав просвітницький і політико-правовий рух. Провідним завданням у цьому контексті він вбачав безпосередню участь відомих діячів того часу у культурно-просвітницькій діяльності, яка поряд із суспільно- політичними ініціативами мала сприяти формуванню української національної свідомості і ідентичності. Маючи належну фахову освіту він чітко усвідомлював, що єдність української нації та її розвиток визначається комплексом якісних здобутків у культурній, науковій, соціальній та інших сферах суспільно-політичного життя, що сприяє належному розвитку української державності.
ІНСТИТУТ АНГЛІЙСЬКОЇ МОВИ В УКРАЇНІ: ІСТОРИКО - ПРАВОВИЙ ВИМІР
Authors: Француз-Яковець Т.А.  , Павлусенко О.В.
Published: July 2023

Ні для кого не секрет, що сучасний світ змінюється з шаленою швидкістю. Зникають видимі та невидимі кордони, як наслідок новітніх систем комунікацій та процесу глобалізації. Сьогодні вже нікого не здивуєш міжконтинентальним спілкуванням. Завдяки сучасним технологіям світ стає доступнішим. Але, такий технологічний прогрес, вимагає від кожного з нас зустрічних трансформацій та систематичного самовдосконалення. Це створює необхідність долучення до світової культури. Більшість такі перспективи лякають, але декого спонукає до розвитку.  
У час, коли Інтернет є  майже у кожній точці світу, ми можемо спілкуватися з ким хочемо, якщо обидва співрозмовники  володіють  однією мовою. Має сенс вивчати іноземні мови. Стимулює нас до цього процесу можливість вільного спілкування та підтримка відносин з людьми інших країн. Доречно зазначити, що ніколи не знаєш, які знання можуть знадобитися завтра. Знання іноземної мови, а ще краще декількох, завжди стануть у пригоді, особливо в бізнесі, кар’єрі, особистому житті тощо. Носієм культури та її передавачем є саме мова. Варто звернути увагу на той факт, що наразі декілька мов у світі змагаються за статус мови майбутнього. Більш ніж півтора мільярди людей говорять китайською, сотні мільйонів французькою, іспанською, португальською та іншими мовами. Але саме англійська займає пальму першості  як мова міжнародного спілкування, є своєрідною візою в світ без кордонів. Дана стаття актуалізує питання правового статусу інституту англійської мови в Україні. У статті досліджено процес формування та розвиток  даного інституту в Україні від початку зародження до сьогодення. Такі знання мають стати міцною основою для формування в суспільстві усвідомлення значення англійської мови як важливого чинника на шляху збереження, стабілізації та майбутньої вiдбудови держави. Здiйснено порiвняльний аналiз з аналогiчними нормами основних законiв інших країн світу.
СТАНОВЛЕННЯ ТА РОЗВИТОК ІНСТИТУТУ ВІДПОВІДАЛЬНОСТІ ЗА ПОРУШЕННЯ ЗАКОНОДАВСТВА ПРО ЗАХИСТ ЕКОНОМІЧНОЇ КОНКУРЕНЦІЇ
Authors: Сидор В.Д.  , Василенко Є.В.
Published: July 2023

В статті досліджується зародження та подальший розвиток національного законодавствапро відповідальність в сфері економічної конкуренції в умовах пострадянських та світових тенденцій. Аналогічні процеси в тій чи іншій мірі відбувались в усіх екс-республіках колишнього Радянського Союзу, однак характерноюрисою для України в цьому питанні є орієнтація на інтеграцію до Європейського Союзу. Обраний нашою країною курс впливає на всі економічні сфери та визначає напрямок законотворчої діяльності, спрямованої та імплементацію сучасних західноєвропейських стандартів регулювання економічної конкуренції в площину сучасної України. Шлях до європейської спільноти є багатоетапним, комплексним і вимагає покрокових законодавчих змін. Кожен наступний етап законотворення має поступово враховувати низку факторів, які безпосередньо впливають на сутність нормотворчих удосконалень. Зокрема, українське законодавство потребує вдосконалення в сфері зловживання монопольним (домінуючим) становищем, регулювання конкуренції, відповідальності за порушення конкуренційних норм за стандартами Європейського Союзу. Втім, кожен подальший крок на шляху законодавчих змін має враховувати поточний стан економічних процесів в Україні задля гармонійного впровадження таких змін в реальні ринкові відносини. Дана стаття висвітлює основні тенденції, які вплинули на становлення і наступний розвиток конкурентного законодавства в Україні. З метою розкриття проблематики дослідницька увага сфокусована на умовах функціонування ринкової економіки, актуальних для окремих історичних етапів розвитку, а також на інтеграційних викликах сучасності, які постали перед державою. Вдосконалення вітчизняного законодавства є ключовим інструментом розвитку інституту відповідальності за порушення в сфері конкурентних правовідносин. Стаття присвячена дослідженню сучасних тенденцій адаптації національного конкурентного законодавства з урахуванням національних інтересів країни. Проведений аналіз дозволяє сформулювати відповідні висновки щодо подальших тенденцій на шляху вдосконалення законодавчого регулювання в Україні відповідальності за різні види порушень в сфері захисту економічної конкуренції.
ІНСТИТУТ МЕДІАЦІЇ: ЗАРУБІЖНИЙ ДОСВІД ТА ВІТЧИЗНЯНІ РЕАЛІЇ
Authors: Француз- Яковець Т.А.  , Бабат О.І.
Published: July 2023

У статті розглядається інститут медіації, а також особливості його застосування в Україні та зарубіжних країнах (США та Великобританії). Досліджено правову природу та сутність медіації як інституту альтернативного вирішення спорів. Визначено особливості правового регулювання процесуальних та методологічних аспектів медіації чинними міжнародно-правовими документами. Проаналізовано світовий досвід європейських країн у застосуванні медіації та положення законодавства, що регулюють її застосування, з урахуванням особливостей існуючих правових систем. Висвітлено реалії та перспективи законодавчого запровадження медіації в Україні. Розглядаючи інститут медіації та особливості його застосування в Україні, автор аналізує досвід застосування інституту медіації та особливості його застосування у США та Великій Британії у використанні медіації як альтернативної процедури вирішення спорів та з'ясовує, чи впливає створення законодавства про медіацію в цих країнах на її поширення та практичну ефективність. Міжнародна практика вже давно закріпила на законодавчому рівні різні альтернативні форми вирішення господарських, цивільних та адміністративних справ, а саме переговори, арбітраж, фасилітацію та медіацію, оскільки ці процедури зазвичай є успішними і конфліктуючим сторонам не доводиться шукати подальшого судового захисту. В Україні законодавці, усвідомлюючи переваги медіації, розробили відповідний закон, який був прийнятий Верховною Радою. Однією з суттєвих переваг медіації є її швидкість у порівнянні з судовим розглядом, адже за статистичними даними за 2020 рік на розгляді суддів перебуває близько 1 407 795 процесуальних звернень та цивільних справ, з яких 291 009 не розглянуто, що свідчить про перевантаження судової системи, яке безпосередньо тягне за собою затягування розгляду справ та порушення однієї з основних засад цивільного судочинства - права на справедливий судовий розгляд. Ефективність медіації в цілому полягає в тому, що основний позитивний ефект полягає в тому, що після її завершення сторони чітко розуміють, що результат, якого вони досягли, був напрацьований ними безпосередньо, і у них не виникає відчуття, що одна з них отримала щось менше, ніж інша. Крім того, варто відзначити гнучкість процедури, оскільки угода, укладена сторонами в результаті медіації, розподіляє їхні права, обов'язки та вигоди зовсім по-іншому, ніж це було б передбачено судовим рішенням, що ґрунтується на нормах права. Крім того, автор також аналізує Закон України «Про медіацію» та застосування медіації в умовах воєнного стану в Україні.
La conceptualización de la identidad transgénero en estados unidos: Un estudio léxico, diacrónico y de corpus
Authors:   Universidad Complutense de Madrid, de la Villa Vecilla Inés
Published: July 2023

Este estudio examina la conceptualización de la identidad transgénero desde una perspectiva diacrónica. El objetivo principal es analizar el desarrollo de los términos más comunes para referirse al colectivo trans en el contexto estadounidense entre el siglo XX y la actualidad: transvestite («travesti»), transsexual («transexual») y transgender («transgénero»). Para ello, se hace uso de los corpus COHA y COCA y se combinan métodos cuantitativos y cualitativos, se analiza la conceptualización de la identidad trans a través de la frecuencia de uso de las palabras y su prosodia semántica. Los resultados muestran una similitud relativa entre transvestite y transsexual tanto en cuestión de distribución como de uso. Ambos términos surgen en el ámbito médico entre los 70 y 80, y se aprecia un cambio de significado hacia uno más coloquial y negativo en el que, en ocasiones, se conceptualiza a mujeres transgénero en términos despectivos y violentos. Los resultados de transgender son significativamente diferentes en cuanto a que surge hacia 2010 y prevalece en contextos mediáticos, políticos, legales y educativos llevando a una conceptualización plural del colectivo y mostrando connotaciones positivas relacionadas con el movimiento en defensa de los derechos trans.
Analysis of Iron and Lead Levels in Groundwater in Sub-Urban Areas of Palembang
Authors: Mariadi Pra Dian , Kurniawan Ian
Published: July 2023

Access to clean water in Indonesia is one of the biggest problems. The main problem faced by the community is due to limited water resources and the problem of limited water quantity. Hence, they are unable to meet the increasing needs of the community. The decline in water quality is due to domestic and industrial waste entering water bodies. The influence of human activities so that pollutants entering the environment's surface, water, and groundwater increases yearly. Toxic and dangerous substances cause many problems to the environment and health. One of the harmful poisonous substances is heavy metals. This observational research is descriptive-analytic by testing the levels of metal iron (Fe), Lead (Pb), and pH of residents' well water. The research sample was collected using a sample grabber for the well water residents of Talang Betutu, Palembang. Samples were examined in the laboratory on the same day. The sample in this study amounted to 7 samples of residents' well water, which is still used for daily activities such as bathing and washing. Examination of heavy metals using a Uv Vis Spectrophotometer. The results showed that all residents' samples contained Fe and Pb at levels that did not exceed the quality standards. The chronic impact of consuming water containing heavy metals must be a concern because it lasts for a specific time.