bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Negative Symptoms on the Social Function of People with Schizophrenia in the Community
Authors: Puspitosari Warih Andan , Soewadi Soewadi , Sumarni Sumarni
Published: October 2020

Abstract: The most People with Schizophrenia (PwS) experience a decline in social function caused by various factors. Clinical symptoms of PwS affect the social function of PwS, especially negative symptoms. The purpose of this study is to analyze the effect of negative symptoms on the social function of people with schizophrenia in the community. This is a cross-sectional study. Subjects of the study were people with schizophrenia aged 18-56 years who will follow Community-Based Rehabilitation activities in 10 areas of puskesmas in Yogyakarta Special Region. The study was conducted in February 2017. The social function and negative symptoms of PwS were measured using a validated measuring instrument. Hypothesis test using Anova test. The subjects of the study were obtained by purposive sampling technique of 100 PwS that fulfilled inclusion and exclusion criteria. Subjects with a PSP score of 0-30 (poor: someone who intensively needs care and social support) of 8 people (8%) had negative PANSS score of 28.50 ± 6.78. Subjects with a score of 31-70 (moderate: someone who occasionally needs care and social support) of 57 people (57%) had negative PANSS of 20.65 ± 8.18. Subjects with a score of 71-100 (mild: someone with mild disturbance, but able to perform individual functions) of 35 subjects (35%) had negative PANSS score of 12.49 ± 5.98. PwS which has a negative value of PANSS is greater, has a worse social function. The results showed that the negative symptoms had an effect on the social function of people with schizophrenia which was statistically significant (p <0.05). Negative symptoms affect the social function of PwS. PwS that has a high negative symptom score, has a worse social function. Keywords: social function, schizophrenia, negative symptoms
Differences in Age and Body Mass Index of Women with Polycystic Ovary Syndrome Attending in Vitro Fertilization (IVF) Program
Authors: Panghiyangani Roselina , Khatimah Husnul , Suryandari Dwi Anita , Wiweko Budi , Kurniati Mala
Published: October 2020

Abstract: Nutritional status in this case BMI in women is very important in relation to infertility problems in women of reproductive age. Polycystic ovary syndrome (PCOS), is a reproductive problem with hormonal disorders. Infertility Female with PCOS is associated with anovulation, high LH and hyperandrogenism. The purpose of this study was to analyze differences in age and body mass index (BMI) of PCOS women undergoing in vitro fertilization (IVF). This was an observational analytic study. The subjects of the study were women aged 30-40 years who undergoing IVF-assisted fertilization program at Yasmin Clinic - RSCM Kencana who was diagnosed as PCOS. As a comparison are women 30-40 years who have infertility problems but not PCOS  who underwent IVF-assisted fertilization program. Women diagnosed with PCOS based on the Rotterdam 2003 consensus definition, and reinforced with ultrasound examinations that show polycystic ovary symptoms. Diagnosis is performed by a specialist in Obstetrics and Gynecology. Age data is taken from medical record and IMT data is calculated based on formula body weight/height2. Data analysis was done by unpaired t test. Mean age of study subjects: 32.21 ± 0.99 years female PCOS and 32.80 ± 0.516 years of non-PCOS group of women, unpaired t-test results were not significantly different (p> 0.05). Mass Index PCOS group 24.425 ± 0.585 Kg/m2 and 22.840 ± 0.494 Kg/m2 non-PCOS group, unpaired t-test results were significantly different (p <0.05). Conclusion of this research was in the PCOS women group had significantly higher BMI rates than the group non PCOS woman.
Obstetrical and Non-Obstetrical Factors toward Uterine Prolapse Occurrence in Ulin General Hospital Banjarmasin on Januari – December 2017
Authors: Putra Yohanes Adhitya Prakasa Sukoco , Suhartono Eko , Budinurdjaja Pribakti
Published: October 2020

Abstract: Uterine prolapse is a gynecological disease in women that emerge patients physically and psychologically. Uterine prolapse is defined as an uterus herniation inside or outside vagina as the result of the ligament and fascia failure that retain the uterus in its actual place. This research was to identify obstetrical and non-obstetrical factors in uterine prolapses occurrence in Ulin General Hospital Banjarmasin on period January until December 2017 using case control approach. The total sample was 80 medical record samples, which divided into 40 medical record samples of patient with uterine prolapse and 40 medical record samples of patient without the occurrence of uterine prolapse. The results using chi square analysis obtained non-obstetrical factors: age >60 years old (OR 6.67: 95%CI 2.44-18.21), BMI > 30 (OR 3.10: 95%CI 1.24-7.71), menopause (OR 21.00: 95%CI 6.11-72.18); and non-obstetrical factors: parity >4 / multiparity (OR 13.78: 95%CI 4.71-40.28), macrosomia (OR 7.15: 95%CI 2.65-19.34), vaginal delivery (OR 28.78: 95%CI 7.41-111.79). The results of logistic regression obtained non-obstetrical factors: age > 60th (Exp B 4.21 and sig. 0.004), menopause (Exp B 1.12 and sig. 0.001), and multiparity (Exp B 2.35 and sig. 0.016). The results of this analysis obtained that obstetrical and non-obstetrical factors were related to uterine prolapse occurrence, and the dominant factor was age > 60 years old, so it could be concluded that there was significant factor between obstetrical and non-obstetrical factors on uterine prolapse occurrence in Ulin General Hospital Banjarmasin. Keywords: uterine prolapse, obstetrical factor, non-obstetrical factor
The Effect of CaCl2 Added PRP (Platelet Rich Plasma) to the Healing Time, Tensile Strength and Adhesion Degree of the Ruptured Tendinopathic Achilles Tendon of Rats (Rattus norvegicus)
Authors: Irsan Istan Irmansyah , Jayanegara R. Muhammad David
Published: October 2020

Abstract: Achilles tendinopathy produce morbidity, long-lasting disability in athletes and non-athletes and remain a challenge for clinician. Tendinopathy may lead to reduced tensile strength and a predisposition to rupture.The aim of our study was to evaluate the effects of activated and non-activated PRP on the healing process of ruptured tendinopathic achilles tendon in rat. Tendinopathy achilles condition induced by injecting collagenase bacterial type-1 locally. Right achilles tendon in 48 rats ruptured by transecting it transversely and repaired it by using a Kessler technique. Further, the wound immobilized with PRP and injecting activated PRP (5% CaCl2 added) in  one group, non-activated PRP on the other group and saline on control group. Tendons from each group were collected at the 1st and 2nd week postoperatively also assessed for biomechanical test. Tendons were also evaluated histologically by using hematoxylin-eosin to know adhesion degree based on Tang criteria. The significant differences was found between intervention group and control (p<0.05) at the 1st week but there was not any significant differences at the 2nd week in tensile strength test (p>0.05). Adhesion degree of the intervention group also reduce better rather than the control at the 1st and 2nd week (p<0.05). PRP have a positive effect on healing tendons by improving healing time, mechanical strength and decreasing adhesion degree. Keywords: achilles tendinopathy, PRP, healing time, tensile strength, adhesion
Analysis of Oral Chronic Kidney Disease with Hemodialysis Therapy in South Kalimantan - Indonesia
Authors: Hatta Isnur , Pratami Khairunnisa Amalia , Apriasari Maharani Laillyza
Published: October 2020

Abstract: Chronic kidney disease (CKD) is a world health problem where the incidence continues to increase, has a poor prognosis and high-level financing. Clinical manifestations of the oral cavity can occur in CKD patients with hemodialysis therapy due to a decrease in the immune system. To analyze the descriptively the clinical manifestations of oral cavity in CKD patients with hemodialysis therapy at RSUD Ulin Banjarmasin South Kalimantan, period January-March 2019. This is a descriptive analysis with a cross sectional study design, based on history and clinical examination of the oral cavity. Data was entered and analyzed using chi square test. Sampling by purposive sampling. there is a relationship between uremic odor and duration of hemodialysis (p = 0.017). There was a relationship between xerostomia and gender (p = 0.035) and there was a relationship between xerostomia and the duration of hemodialysis (p = 0.007). There is a relationship between gingival swelling and age (p = 0.010) and there is a relationship between gingival swelling and diabetes mellitus (p = 0,000). Manifestations found in the oral cavity of CKD patients with hemodialysis therapy are uremic odor, mouthache, xerostomia, mucosal lesions, candidiasis, and gingival swelling. There is a relationship between sex with xerostomia, the relationship between age with gingival swelling, the relationship between the duration of hemodialysis with uremic odor and xerostomia, the association between DM with gingival swelling. Keywords: Chronic Kidney Disease, Clinical Manifestations, Hemodialysis, Oral Cavity
The Differences Analysis of Temperature, Salinity, and Dissolved Oxygen of Aedes aegypti Breeding Place Water in Endemic and Non-Endemic Areas
Authors: Hidayah Nurul , Rahmawati Dwi
Published: October 2020

Abstract: The study aims to determine differences in water quality of breeding sites in endemic and non-endemic areas. The method used is quantitative observational analytic with a case control study design. Case group was water parameters in endemic areas and the control group is in non-endemic areas. 43 samples of breeding water were taken from each area then water quality measurements were carried out. Data were analyzed using independent t-test. The results obtained mean temperature in endemic areas 27.51 ± 0.739 oC, salinity 2,544 ± 0.638 gr/l, and DO 7,253 ± 1,097 mg/l. The mean temperature in non-endemic areas is 25.7 ± 1.124 oC, salinity is 2.472 ± 2.365 gr/l, and DO is 6.479 ± 1.059 mg/l. P-value of statistical tests of differences in temperature, salinity, and DO parameters in endemic and non-endemic areas are 0.000, 0.266, and 0.001. It was concluded that temperature and DO parameters in endemic areas proved to be significantly different from those in non-endemic areas. However, for salinity variables there are no significant differences. Keywords: Aedes aegypti, dissolved oxygen, salinity, temperature
Analysis Regarding Quality of Life of Menopausal Women on Clinical Disorders during Menopausal Period, on Sukomanunggal Sub-District Surabaya in 2019
Authors: Siahaan Salmon Charles , Henderi Hendera , C V Ardelia , W Ridzal , KP Azyvati
Published: October 2020

Abstract: Approximately 70% of women in the peri period and post menopause experience vasomotor complaints, depression, psychological and somatic complaints. The severity of the symptoms will be different for each woman. This research was conducted to find out whether the clinical symptoms that appear in menopausal women will cause disruption to quality of life. This study was conducted on menopausal women at Geriatric Poly at Simomulyo Health Center Surabaya in March - April 2019 using cross sectional method. Questionnaire was used to measure clinical symptoms in menopausal women and the QOLWHO-BREF questionnaire to assess the quality of life of menopausal women. Menopausal women in this study were at the age of 60.89 + 6.55 years. Menarche at the age of 12.49 + 1.74 years and Menopause at 49.41 + 4.88 years. For the BMI category mean at 24.33 + 4.02 kg / m2. Based on contraception used, it was found that most of women used combination pills (36.8%). Menopausal complaints consist of physical complaints and psychological complaints, for the major complaints from physical are complaints regarding bone and joint pain (86.5%) and for major complaints from psychological factor is a decrease in sexual desire (72.9%). The category of the amount of variety clinical symptoms that appear in each woman, it was found that at most of menopausal women felt 3 complaints (67.6%; 13.24 + 1.76). For the quality of life (WHOQOL) results, the overall quality of life criteria is in the very bad and bad category with the environmental domain being the lowest (3.04 + 10.93) and the better category compare than the other is the social relations domain (29.82 + 4.74) . The results of data analysis through the Spearman correlation test showed that there was a relationship between the number of complaints with a decrease in quality of life (Z = 3.15433; p = 0.00164) and it was found that menopausal women with complaints of menopause affected the decrease quality of life (Z = -4.30769; p <0.00001). Based on this study it was found that the factors that significantly influence the quality of life of a menopausal woman are clinical symptoms that appear both from physical symptoms and psychological symptoms. appears also has a significant effect on decreasing the quality of life of a menopausal woman Keyword: Menopause, clinical symtoms, quality of life
Correlation between Endobutton Position and Functional Outcome After ACL Reconstruction: Plain Xray Evaluation
Authors: Mahyudin Mahyudin , Wibowo Ricky , Utoyo Ghuna Arioharjo
Published: October 2020

Abstract: The correct positioning of the femoral tunnel and endobutton position determine the success of ACL reconstruction (ACLR). Improper femoral tunnel placement most common errors in failed ACLR. However, plain post-operative imaging in the early state is not routinely performed. EndoButton position evaluation by XRay was made because this technique was cheap and reliable in Indonesia. There is no consensus on the ideal positioning of EndoButton in compare with functional outcome after ACLR.  The study aimed to evaluate anatomic positions of tunnel and fixation devices, and also provide a baseline examination for future controls regarding tunnel placement and fixation devices, and also evaluation functional outcome after ACL procedure and also evaluation of functional outcome after ACLR with IKDC score. Between February 2019 to July 2019, 20 patients aged 17 to 59 years, with post ACL reconstruction were involved in this study. We are evaluating sex, age, affected the side of the knee, complication after an operation, related activity with injury, and evaluation postoperatively with femoral angle measurement Xray AP and lateral view. We also evaluated and correlate post ACRL and functional outcomes with the International Knee Documentation Committee (IKDC) score. The mean age of patients was 28,38 ± 9,3 years, (87,15% men and 12,5% women). There is no complication after the operation in all patients. Nine patients (56,3%) affected on the left side, and seven patients (43,8%) affected right-sided. All patients are performed single-bundle augmentation techniques for ACL reconstruction. Five (31,3%) patient has history fall and eleven (68,8%) patients caused by sports activity. All patient has Femoral angle measurement from knee AP view x-rays more than 17o, with minimum 39o and maximum 54o, with mean 46,63 ± 4,2. From lateral x rays, we interpreted nine patients (45%) interpreted as shallow and high, and 55% others interpreted as deep and low (optimal). The mean of IKDC score pre-op was 58,1±4,6 and means IKDC postoperatively 6 months was 84,68 ± 5,1. There was a significant difference in functional outcome between optimal endobutton and not optimal endobutton position group with p-value < 0,05. Early post-operative imaging (knee x-rays) provides useful information regarding tunnel placement and fixation devices. It also serves as a baseline examination for future reference. In this study, a single bundle ACL reconstruction shows a satisfying outcome. Keywords: Anterior cruciate ligament; knee; postoperative reconstruction; radiograph.
Number of Urogenital Disorders Visits in The Emergency Room of dr. H. Andi Abdurrahman Noor General Hospital
Authors: Saputera Bayu , Prasetya Heru
Published: October 2020

Abstract: In urology, urogenital disorders include all male and female urinary tract and male genital organ abnormalities. These disorders can be an infections, blockages due to foreign bodies, dysfunction due to pathological or degenerative processes, trauma, neoplasms, or congenital disorders. This research was a retrospective descriptive study to determine the number of patient visits with urogenital disorders. The place of this research was ER of DHAAN General Hospital, Tanah Bumbu District, South Kalimantan Province, Indonesia. The research data was taken from data on new patient visits to the ER in 2017. The number of patient visits with urinary tract disorders was 475 cases: male 57.1% and female 42.9%. The most cases based on the type of disorder was UTI (38.9%), second was urolithiasis (25.3%), and third was CKD (23.4%). While the number of patient visits with male genital disorders was 79 cases. Most cases was BPE (86.1%). Knowing the number of patient visits with urogenital disorders will make the clinicians be directed in preparing themselves for urogenital emergencies in their respective health services. Keywords: DHAAN, number of visits, urogenital disorders, urology.
Pediatric Air Gunshot Penetrating Head Injury with Good Outcome: A Case Report
Authors: Ramadhan Yusriandi , Abidin Zainal , Lahdimawan Ardik Lahdimawan
Published: October 2020

Abstract: Ball bearing (BB) and pellet guns are non-power guns but their related injuries have been reported worldwide. They represent a significant cause of injury especially among children and teenagers. Their potentially harmful and lethal effects have been well documented in the medical literature since the early 1980s. Fatality rate is closely related to the damaged part of the brain and the level of the damage. In this Case Report we documented a 6-years-old girl was getting shot at the head by herself, who initially want to play around, using her neighbour’s Air gun rifle. The pellet trajectory passed through the left frontal lobe, left temporal lobe, left posterior putamen, posteriorly left crus posterior of internal capsule, left occipital horn of lateral ventricle, left occipital lobe, and ended at left cerebral falx between both medial surfaces of occipital lobes. Directional slope of the pellet was medially upward, with its tracking left Intracerebral Hemorrhage (ICH) with perifocal edema and Intraventricular Hemorrhage (IVH) dominant in the left lateral ventricle. After 8 days management, the patient was discharged from our hospital with stable condition, GCS 15 without any significant neurological deficits. Intracranial intracerebral pellet due to air gun shot injury, may have fatal and lethal manifestation if the pellet damage the eloquent area and/or deep area of the brain (hypothalamus, thalamus and brain stem). If accessible the foreign body or pellet should be removed immediately for better outcome. Keywords: Head Injury, Air Gun Shot, Intracerebral Haemorrhage
EIT-MESHER – Segmented FEM Mesh Generation and Refinement
Authors: Dowrick Thomas , Avery James , Faulkner Mayo , Holder David , Aristovich Kirill
Published: October 2020

EIT-MESHER (https://github.com/EIT-team/Mesher) is C++ software, based on the CGAL library, which generates high quality Finite Element Model tetrahedral meshes from binary masks of 3D volume segmentations. Originally developed for biomedical applications in Electrical Impedance Tomography (EIT) to address the need for custom, non-linear refinement in certain areas (e.g. around electrodes), EIT-MESHER can also be used in other fields where custom FEM refinement is required, such as Diffuse Optical Tomography (DOT).
Deciphering the Relationships Among Enzymatic Systems and Virulence of Beauveria bassiana: A Review
Authors: Dhawan Manish , Joshi Neelam , Ghuman Samandeep , Sandhu Saroop , Sharma Meenu
Published: October 2020

Intensive crop production and extensive use of harmful synthetic chemical pesticides create numerous socio-economic problems worldwide. Therefore, sustainable solutions are needed for insect pest control, such as biological control agents. The fungal insect pathogen Beauveria bassiana has shown considerable potential as a biological control agent against a broad range of insects. The insights into virulence mechanism of B. bassiana is essential to show the robustness of its use. B. bassiana has several determinants of virulence, including the production of cuticle-degrading enzymes (CDEs), such as proteases, chitinases, and lipases. CDEs are essential in the infection process as they hydrolyze the significant components of the insect's cuticle. Moreover, B. bassiana has evolved effective antioxidant mechanisms that include enzyme families that act as ROS scavengers, e.g., superoxide dismutases, catalases, peroxidases, and thioredoxins. In B. bassiana, the number of CDEs and antioxidant enzymes characterized in recent years. The enzymatic activities are crucial for the biological control potential and significantly advanced our understanding of the infection mechanism of B. bassiana. This review focuses on the progress detailed in the studies of these enzymes and provides an overview of enzymatic activities and their contributions to virulence.
Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation
Authors: Lustig Robert H.
Published: October 2020

Past public health crises (e.g. tobacco, alcohol, opioids, cholera, HIV, lead, pollution, venereal disease, even COVID-19) have been met with interventions targeted both at the individual and all of society. While the healthcare community is very aware that the global pandemic of non-communicable diseases (NCD’s) has its origins in our Western ultraprocessed food diet, society has been slow to initiate any interventions other than public education, which has been ineffective, in part due to food industry interference. This article provides the rationale for such public health interventions, by compiling the evidence that added sugar, and by proxy the ultraprocessed food category, meets the four criteria set by the public health community as necessary and sufficient for regulation — addiction, toxicity, ubiquity, and externalities (how does your consumption affect me?). To its credit, some countries have recently heeded this science and have instituted sugar taxation policies to help ameliorate NCD’s within their borders. This article also supplies scientific counters to food industry talking points, in order to guide both scientists and policy makers in instituting further appropriate public health measures to quell this pandemic.
A Perspective on Cell Tracking with Magnetic Particle Imaging
Authors: Sehl Olivia C. , Gevaert Julia J. , Melo Kierstin P. , Knier Natasha N. , Foster Paula J.
Published: October 2020

Magnetic Particle Imaging (MPI) is a new imaging modality that sensitively and specifically detects superparamagnetic iron oxide nanoparticles (SPIONs). Many labs have been developing cellular magnetic resonance imaging (MRI) tools using both SPIONs and fluorine-19 (19F)-based contrast agents for numerous important applications, including tracking of immune and stem cells used for cellular therapies. SPION-based MRI cell tracking has very high sensitivity, but low specificity. SPIONs produce negative contrast in MRI, or signal voids. SPIO is not directly detected by MRI, but indirectly through its relaxation effects on protons, therefore, it is not possible to reliably quantify the local tissue concentration of SPION particles and cell number cannot be determined. 19F based cell tracking uses perfluorocarbons (PFC) to label cells. The number of 19F atoms can be directly measured from 19F MR images and related to cell number. 19F MRI has high specificity, but low sensitivity. MPI cell tracking displays great potential for overcoming the challenges of MRI-based cell tracking allowing for both high cellular sensitivity and high specificity and quantification of SPIO labeled cell number. In this paper we describe nanoparticle and MPI system factors that influence MPI sensitivity and resolution, quantification methods and give our perspective on testing and applying MPI for cell tracking.
Cross-polarization Optical Coherence Tomography Probes for Intraoperative Application in Neurosurgery
Authors: Yashin Konstantin , Shilyagin Pavel , Kiseleva Elena , Gelikonov Grigory , Romashov Vladimir , Moiseev Alexander , Medyanik Igor , Ksenofontov Sergey , Achkasova Ksenia , Kravetz Leonid , Potapov Alexander , Gladkova Natalia
Published: October 2020

Optical coherence tomography (OCT) is one of the most promising, innovative and rapidly emerging intraoperative imaging modalities for neurosurgical guidance in brain tissue imaging, "optical biopsy", brain cerebral vascular detection, nerve fibers and white matter tracts detection. In this article, we provide a short survey of cross-polarization OCT and different types of OCT probes that can be used in routine neurosurgical practice. Through different types of probes there are multiple applications where OCT can play a highly complementary role in offering the real-time microscopic assessment and imaging of normal and pathological brain tissues. The biopsy-needle based probe for CP OCT was shown to be an effective instrument for brain tissue mapping and express estimation of tissue status as well as for detecting large blood vessels to prevent causing bleeding during biopsy sampling. The folded CP OCT probe for intraoperative use for brain tissue examination was shown as a potentially efficient sensor head for CP OCT. The probe demonstrated high lateral resolution in diffractive limited probing beam quality. The length of dismountable probe tip allows using the probe under operating microscope. Due to the designed family of specialized probes CP OCT fills in the niche of devices for express brain tissue examination in situ.
Introducing Two New Sieves for Factorization Natural Odd Numbers
Authors: Maleki Chorei Ramazanali
Published: October 2020

For each non-prime odd number as F=pq , if we consider m/n as an approximation for q/p and choose k=mn , then by proving some lemmas and theorems, we can compute the values of m and n. Finally, by using Fermat’s factorization method for F and 4kF as difference of two non-consecutive natural numbers, we should be able to find the values of p and q. Then we introduce two new and powerful sieves for separating composite numbers from prime numbers.
Association Mapping for Drought Tolerance and Yield-Related Traits in Cowpea Accessions
Authors: Nkomo Gabriel Vusanimuzi , Sedibe Moosa , Mofokeng Maletsema Alina , Pierneef Rian
Published: October 2020

The objective of this study were to conduct association mapping for drought tolerance at the seedling stage and yield-related traits. 60 cowpea accessions were used in the study. Single-nucleotide polymorphisms (SNPs) discovered through genotyping by sequencing (GBS) were used for genotyping. Association mapping was conducted using single-marker regression (SMR) in Q Gene, and general linear model (GLM) and mixed linear model (MLM) built in TASSEL. The population of the cowpea accessions were analysed using STRUCTURE 2.3.4 and the peak of delta K in the greenhouse showed seven population types, whereas the peak of delta K in the glasshouse indicated the presence of six population types. One SNP marker, 14083649|F|0-9 was associated with NP with a p value <0.001. Fifty SNP markers were associated with PWT at p <0.001. Four SNP markers, 14074781|F|0-16, 100047392|F|0-36, 14083801|F|0-28 and 100051488|F|0-49 were associated with AVSPD at p <0.001. SNP markers, 14074781|F|0-16, 14083801|F|0-28 and 100051488|F|0-49 were associated with PL at P <0.001. Five SNP markers, 100047392|F|0-36, 14083801|F|0-28, 100072738|F|0-34, 14076881|F|0-49 and 14076881|F|0-49 were associated with PWDTH at p <0.001. The 65 SNP markers identified can be used in cowpea molecular breeding to select for AVSPD, NP, PL, PWDTH, PWT, and RR through marker assisted selection (MAS).
Goodness-of-fit Test for the Bivariate Hermite Distribution
Authors: Novoa-Muñoz Francisco , González-Albornoz Pablo
Published: October 2020

This paper studies the goodness of fit test for the bivariate Hermite distribution. Specifically, we propose and study a Cramér-von Mises-type test based on the empirical probability generation function. The bootstrap can be used to consistently estimate the null distribution of the test statistics. A simulation study investigates the goodness of the bootstrap approach for finite sample sizes.
Pioglitazone is Associated with Lower Major Adverse Cardiovascular and Cerebrovascular Events than DPP4-Inhibitors in Diabetic Patients with End-Stage Renal Disease: A Taiwan Nationwide Cohort Study, 2006-2016
Authors: Lin Min-Hao , Yang Huang-Yu , Yen Chieh-Li , Wu Chao-Yi , Jenq Chang-Chyi , Kuo George , Peng Wei-Sheng , Liu Jia-Rou , Tian Ya-Chung , Yang Chih-Wei , Anderson Gerard , See Lai-Chu
Published: October 2020

While pioglitazone reduces insulin resistance and hepatic gluconeogenesis effectively in patients with T2DM, these benefits remained controversial in patients with ESRD. We compared MACCEs and mortality (overall, infection-related, and MACCE-related) of pioglitazone to that of DPP4-inhibitors in patients with T2DM and ESRD. From Taiwan’s national health insurance database, 647 pioglitazone users and 6080 DPP4-inhibitors users between April 1st, 2006 and December 31th, 2016 were followed from the 91th date after the ESRD certification till study outcomes, independently; withdraw from the NHI program, death, or Dec. 31th, 2017. After weighting, risks of MACCEs (10.48% vs 12.62% per person-years, [HR]: 0.85, 95% [CI]: 0.729–0.985) and all-cause mortality (12.86% vs 13.22% per person-years, [HR]: 0.88, 95% [CI]: 0.771–0.995) are significantly lower in pioglitazone group. Subgroup analysis found lower MACCEs risk in the pioglitazone users without insulin therapy (6.44% vs 10.04% [HR]: 0.59, 95% [CI]: 0.42–0.82) and lower MACCEs related death (2.76% vs 3.84% [HR]: 0.61, 95% [CI]: 0.40–0.95) in the pioglitazone group with dyslipidemia, when comparing with DPP4-inhibitors users. Pioglitazone is associated with lower all-cause mortality and MACCEs in diabetic patients with ESRD, compared to DPP4-inhibitors. These benefits were further significant in the non-insulin users and patients with dyslipidemia.
Dosis dan Waktu Aplikasi Boron Terhadap Pertumbuhan dan Hasil Kacang Hijau
Authors: Nurani Krisna Cahya , Budiyanto Susilo , Purbajanti Endang Dwi
Published: October 2020

Green beans are legume plants that are in great demand because of their high nutrition content and include plants that require boron to support growth from the vegetative to generative phase. The study aims to assess the growth and production of green beans due to influence of the dose and time of boron application. The research was carried out using completely randomized design with factorial pattern 3×3 with 3 replications. The first factor was the treatment of boron doses of 1, 1.5, and 2 kg/ha was given once at 7 Day After Planting (DAP), fertilizer application twice at 7 and 28 DAP, and once given at 28 DAP. The results showed that dose of boron at a dose of 1 kg/ha was able to produce the number of affective root nodules and the best pod weight. The treatment of boron once at 7 DAP can increase plant height, flowering age, pod weight, and seed weight per pod. The interaction between dose and time of boron application affects the number of affective root nodules and seed weight per pod.
Pemberian Beberapa Jenis Biochar Terhadap C-Organik dan N-Total Pada Pertumbuhan Bibit Kelapa Sawit
Authors: Yosephine Ingrid Ovie , Sakiah Sakiah , Siahaan Erpands Abdi Lestari
Published: October 2020

Vegetative growth response of palm oil DxP Dumpy variety using biochar rice husks, oil palm shells, corncobs and coconut shells in the Main Nursery, aims to determine the effect of the administration of several types of biochar on increasing C-organic and N-total in ultisol in the main nursery of oil palm plants. This research has been carried out at the Agricultural Agribusiness College of Agriculture Practices (STIPAP) Medan and soil analysis was carried out at the Asian Agri Laboratory, starting in March-August 2019. The method used was Randomized Group Design (RBD) non factorial with 3 replications, while the treatment factors used were B0 (NPK Compound), B1 Biochar Rice Husk (50 g/polybag), B2 Biochar Palm Oil Shell (50 g/polybag), B3 Biochar Corn Cobs (50 g/polybag), B4 Coconut Shell Biochar (50 g/polybag). The parameters observed were plant height (cm), girth (cm), number of leaves (strands), root wet weight (gr), root dry weight (gr) and pH, C-organik, and N-total soil. The results showed that the biochar treatment of rice husks, palm shells, corncobs and coconut shells had no significant effect on the observed parameters such as plant height, girth, number of leaves (strand, wet weight of roots and root dry weight, pH and N-total soil, but have a very significant effect on the increase in C-organic soil.
Crowdfunding Cannabidiol (CBD) for Cancer: Hype and Misinformation on GoFundMe
Authors: Zenone Marco , Snyder Jeremy , Caulfield Timothy
Published: October 2020

Objectives. To use crowdfunding campaigns to better understand how cannabidiol (CBD) is represented (and misrepresented) as cancer-related care.

Methods. We analyzed CBD-related crowdfunding campaigns (n = 155) created between January 2017 and May 2019 in multiple countries on GoFundme.com .

Results. More than 81.9% of campaigns fundraised CBD for curative or life-prolonging reasons, and 25.2% fundraised for pain management.

Conclusions. Most campaigns seeking funds for CBD for cancer-related care on GoFundMe are for curative or life-prolonging purposes and present CBD definitively as an effective treatment option. In general, campaigners supported their funding requests with anecdotal claims of efficacy and referenced sources of information that were either not evidence-based or that misrepresented existing evidence.

Public Health Implications. Misinformation around CBD for cancer is widespread on medical crowdfunding campaigns. Given the potential adverse impact, crowdfunding platforms, like GoFundMe, must take steps to address their role in enabling and spreading this misinformation.
Breast Cancer Prevention and Treatment: Misinformation on Pinterest, 2018
Authors: Wilner Tamar , Holton Avery
Published: October 2020

Objectives. To quantify and describe the incidence of misinformation about breast cancer on the social media platform Pinterest, a leading source of women’s health (e.g., breast cancer) information.

Methods. We performed a hand-coded content analysis on 797 Pinterest posts (“pins”) mentioning the terms “breast cancer” or “breast” and “cancer,” collected in November 2018.

Results. From the original sample of 797, 178 (22.3%) made a factual claim about what social media users could do to prevent or treat breast cancer. Of these, more than half—91 (51.1%)—contained misinformation. Therefore, 11.4% of the sample overall contained misinformation related to breast cancer prevention or treatment.

Conclusions. Pinterest is a significant vector of misinformation about breast cancer, especially given the platform’s overwhelmingly female composition and its visual means of conveying information.

Public Health Implications. Health practitioners should be aware of the myths circulating about breast cancer prevention and treatment and be prepared both to dismantle misinformation and to stress reliable health guidance. Meanwhile, Pinterest may wish to widen the criteria it uses for identifying health misinformation on its platform.
HPV Vaccine Searches on Pinterest: Before and After Pinterest’s Actions to Moderate Content
Authors: Guidry Jeanine P. D. , Vraga Emily K. , Laestadius Linnea I. , Miller Carrie A. , Occa Aurora , Nan Xiaoli , Ming Hannah M. , Qin Yan , Fuemmeler Bernard F. , Carlyle Kellie E.
Published: October 2020

Objectives. To compare how human papillomavirus (HPV) vaccination was portrayed on Pinterest before and after the platform acted to moderate vaccine-related search results to understand (1) what the information environment looked like previously and (2) whether Pinterest’s policy decisions improved this environment in terms of sources and content.

Methods. In this quantitative content analysis, we compared 2 samples of 500 HPV vaccine–focused Pinterest posts (“pins”) collected before and after Pinterest’s actions to provide more reliable vaccine-related information. Pins were based on search results and were analyzed using the Health Belief Model.

Results. The majority of preaction search results leaned toward vaccine skepticism, specifically focused on perceived vaccine barriers. Few pins were published by public health–related Pinterest accounts. Postaction search results showed a significant shift to HPV vaccination benefits, and the number of pins by government or medical accounts increased. However, the proportion of pins in search results containing HPV content of any type was significantly lower.

Conclusions. Pinterest’s efforts to moderate vaccination discussions were largely successful. However, the ban also appeared to limit HPV vaccination search results overall, which may contribute to confusion or an information vacuum.
Facebook Pages, the “Disneyland” Measles Outbreak, and Promotion of Vaccine Refusal as a Civil Right, 2009–2019
Authors: Broniatowski David A. , Jamison Amelia M. , Johnson Neil F. , Velasquez Nicolás , Leahy Rhys , Restrepo Nicholas Johnson , Dredze Mark , Quinn Sandra C.
Published: October 2020

Objectives. To understand changes in how Facebook pages frame vaccine opposition.

Methods. We categorized 204 Facebook pages expressing vaccine opposition, extracting public posts through November 20, 2019. We analyzed posts from October 2009 through October 2019 to examine if pages’ content was coalescing.

Results. Activity in pages promoting vaccine choice as a civil liberty increased in January 2015, April 2016, and January 2019 (t[76] = 11.33 [P < .001]; t[46] = 7.88 [P < .001]; and t[41] = 17.27 [P < .001], respectively). The 2019 increase was strongest in pages mentioning US states (t[41] = 19.06; P < .001). Discussion about vaccine safety decreased (rs[119] = −0.61; P < .001) while discussion about civil liberties increased (rs[119] = 0.33; Py < .001]). Page categories increasingly resembled one another (civil liberties: rs[119] = −0.50 [P < .001]; alternative medicine: rs[84] = −0.77 [P < .001]; conspiracy theories: rs[119] = −0.46 [P < .001]; morality: rs[106] = −0.65 [P < .001]; safety and efficacy: rs[119] = −0.46 [P < .001]).

Conclusions. The “Disneyland” measles outbreak drew vaccine opposition into the political mainstream, followed by promotional campaigns conducted in pages framing vaccine refusal as a civil right. Political mobilization in state-focused pages followed in 2019.

Public Health Implications. Policymakers should expect increasing attempts to alter state legislation associated with vaccine exemptions, potentially accompanied by fiercer lobbying from specific celebrities.
Limited Role of Bots in Spreading Vaccine-Critical Information Among Active Twitter Users in the United States: 2017–2019
Authors: Dunn Adam G. , Surian Didi , Dalmazzo Jason , Rezazadegan Dana , Steffens Maryke , Dyda Amalie , Leask Julie , Coiera Enrico , Dey Aditi , Mandl Kenneth D.
Published: October 2020

Objectives. To examine the role that bots play in spreading vaccine information on Twitter by measuring exposure and engagement among active users from the United States.

Methods. We sampled 53 188 US Twitter users and examined who they follow and retweet across 21 million vaccine-related tweets (January 12, 2017–December 3, 2019). Our analyses compared bots to human-operated accounts and vaccine-critical tweets to other vaccine-related tweets.

Results. The median number of potential exposures to vaccine-related tweets per user was 757 (interquartile range [IQR] = 168–4435), of which 27 (IQR = 6–169) were vaccine critical, and 0 (IQR = 0–12) originated from bots. We found that 36.7% of users retweeted vaccine-related content, 4.5% retweeted vaccine-critical content, and 2.1% retweeted vaccine content from bots. Compared with other users, the 5.8% for whom vaccine-critical tweets made up most exposures more often retweeted vaccine content (62.9%; odds ratio [OR] = 2.9; 95% confidence interval [CI] = 2.7, 3.1), vaccine-critical content (35.0%; OR = 19.0; 95% CI = 17.3, 20.9), and bots (8.8%; OR = 5.4; 95% CI = 4.7, 6.3).

Conclusions. A small proportion of vaccine-critical information that reaches active US Twitter users comes from bots.
Innovative Directions of Tourism Development
Authors: Alimova Mashhura Toirxonovna , Abdusaidova Shirin Yakubovna , Tuychiev Inoyatillo Ismatilloyevich
Published: October 2020

In the article, the introduction of innovations in the field of tourism is considered as an important factor in the competitive world of the tourism market. The essence of innovation in this regard is revealed based on a theoretical analysis of the definitions given by this category of scientists. There are also presented directions of innovative development of the tourism sector through the application of information technologies in the field.
The Improving of the Quality Resources of Gedog Batik Craftsmen in Tuban Regency
Authors: Widiana Muslichah Erma , Retnowati Nova , Slamet Agus , Slamet Agus , Sagirani Tri
Published: October 2020

This study aims to improve business management of partner business UD.  Batik "Lestari Arts".  The Government of Indonesia has prepared a number of policies to protect and prepare micro, small and medium-sized businesses to produce high-quality products that have high competitiveness.  Tuban is one of the towns in East Java that has an MSME named UD Batik "Lestari Arts" that produces superior products in the form of gedog batik.  The Regional Superior Product Development Program, partnering with UD.  Batik "Lestari Arts", resulted in improvements on two main focuses of partner business management, namely on business resources and the use of science and technology in running a business.  This program is ongoing and continuing through the activities of mentoring, monitoring and evaluating results after two years of partnership.
Self-acceptance of Mothers who have Children with Special Needs
Authors: Islami Eriza Dwi Putri , Ansyah Eko Hardi
Published: October 2020

This study aims to describe students who have children with special needs and describe what factors affect mothers who have expectional children. The method used in this study is qualitative with case study desig. Research subjects were mothers of expectional children with the type of mental retardation,  hearing impairment and cerebral palsy. Determination  of research  subjects using purposive sampling. Data collection method used are interview and observation techniques. The results of this study indicated that the description of acceptance of self  from  the  three  mothers  has  expectional  children,  namely  accepting  the  conditions  experienced,  still ditions experienced. Factors  that influense the formation of self acceptanse are education, social support, family and religious parenting.
Metodologías de aprendizaje cooperativo a través de Tecnologías de la Información y la Comunicación (TIC)
Authors: Gutiérrez Rubio David , Calderón Santiago Mónica , Chamorro Barranco Pedro P. , Luque Salas Bárbara , Reina Giménez Amalia , García Peinazo Diego , Ojeda Nogales David , De la Mata Agudo Carmen , Calderón Santiago Mónica , Antolí Cabrera Adoración
Published: October 2020

El desarrollo de las tecnologías de la información y comunicación (TIC) permite en el ámbito docente la posibilidad de realizar actividades que suelen resultar atractivas para el alumnado. Cuando están vinculadas de una manera pertinente hacia las competencias que se pretenden conseguir en el proceso de enseñanza-aprendizaje, tienen un gran valor didáctico. Si este tipo de actividades se combina o enmarca en una metodología de trabajo cooperativo, el efecto puede ser muy positivo en la actividad docente. Las estructuras cooperativas gozan de un consistente apoyo en relación a los resultados de aprendizaje, así como sobre otros factores como la motivación personal, la valoración propia o las relaciones establecidas entre el alumnado. El presente trabajo describe una experiencia conjunta que pone en valor el trabajo cooperativo como estrategia didáctica, y la utilización de las TIC como instrumento metodológico en diferentes asignaturas y grados en la Universidad de Córdoba realizada durante el curso académico 2018-19. Se analizan sus efectos, así como aspectos a tener en cuenta para su implementación. Siendo la valoración general positiva se observa que el alumnado se implica y aumenta el trabajo autónomo con esta metodología junto con la necesidad de sistematización de la tarea por parte del profesorado.
Mejora de la coordinación de las asignaturas a través de la generación automática de actas basadas en la comunicación vía email
Authors: García Díaz Vicente , González García Cristian , Rolando Núñez-Valdez Edward
Published: October 2020

El proyecto consiste en la realización de una plataforma digital que permite la realización automática de actas de coordinación de asignaturas a partir de los hilos de las conversaciones establecidas en los envíos de correos electrónicos por parte de los diferentes equipos docentes participantes en dichas asignaturas. Las actas pueden generarse a partir de las conversaciones de los docentes, así como de la comunicación entre alumnos y docentes.

Este trabajo se motiva en que las reuniones realizadas de forma virtual raramente van acompañadas de un acta donde se deja constancia de los participantes, de sus declaraciones, de las fechas en las que se realizaron las mismas y de las conclusiones a las que se llegaron.

El principal objetivo es de dejar constancia de todos los trabajos de coordinación realizados de una forma sencilla, sin que para ello los intervinientes tengan que realizar ninguna tarea adicional, a partir de los correos enviados entre profesores alumnos de una asignatura. Estos correos se analizan y recopilan de forma automática. Después, se genera el acta en formato PDF, que puede ser leído por prácticamente cualquier dispositivo.

La aplicación fue probada en dos asignaturas y se aportan capturas y la información relativa a su uso. La aplicación consiguió recopilar toda la información de los correos de forma automática y crear las actas.
Aplicación del aprendizaje cooperativo a través de Tumblr para la adquisición de competencias
Authors: Toledo Padrón Manuel , Cuesta Vázquez Antonio José , Siles López José Ángel , Martín Santos María de los Ángeles
Published: October 2020

El potencial de las redes sociales ha supuesto la aparición de herramientas alternativas para la adquisición de competencias a través de dinámicas de trabajo en grupo e interacción social. El objetivo de este proyecto es que el alumnado construya su propio aprendizaje y se enriquezca del intercambio de ideas y la cooperación con sus compañeros/as. El alumnado fue dividido en grupos de 5-7 componentes y se llevó a cabo una sesión introductoria en la creación de un microblog y de planificación de actividades a través de la plataforma Tumblr. Entre los resultados más destacados, se observó una tasa de éxito (91%) y rendimiento (66%) más elevada que en la anualidad previa. Los grupos con publicaciones de calidad y rigor científico mostraron una mayor tasa de éxito que los grupos con un elevado número de publicaciones menos selectivas. El número de aprobados con un rango de 5,0 a 7,5 se vio incrementado, lo que se traduce en una mejora en la adquisición de competencias y conocimientos. Por lo tanto, esta herramienta educativa innovadora permite al alumnado generar interdependencia positiva; promover valores como la responsabilidad, comunicación y trabajo en equipo; mejorar las relaciones interpersonales y habilidades sociales; y construir conocimiento en sociedad.