Analysis of the migraine characteristics in the perimenopause
Authors: Klimentova D. A. , Tabeeva G. R. 
Published: February 2025

Characteristics of migraine in perimenopause have not been sufficiently analyzed.

Objective. To compare the course of migraine in patients of reproductive age (RA) and in perimenopause.

Material and methods. The observational cross-sectional study involved 120 women suffering from migraine: 60 in the RA group (mean age – 32.28 years), 60 in the perimenopause group (mean age – 48.13 years). Patients were interviewed and questionnaires were filled in, HIT-6, MIBS-4, HURT, Migraine ACT, MIDAS, SF-36, HADS and ISQ scales were used.

Results. The indicators of pain intensity, the duration of attacks and the number of days with headache per month are significantly higher in perimenopause than in RA (p<0.05). The risk of severe impact of headache on quality of life (HIT-6) and migraine burden outside of attacks (MIBS-4) are also significantly higher in perimenopause than in RA (OR=1.9 and OR=1.7, respectively; p><0.05), and most quality of life indicators (SF-36) are lower (p><0.05). The risk of arterial hypertension and musculoskeletal diseases is higher in perimenopause than in RA (OR=2.8 and OR=4.25, respectively; p><0.05). The risk of clinically pronounced anxiety and insomnia is higher in perimenopause than in RA (OR=2.4 and OR=5.15; p><0.05). Conclusion. The course of migraine in women in perimenopause is less favorable than in RA. Further studies are needed to determine the causes of the observed phenomena and to develop clinical guidelines for the treatment of perimenopausal migraine patients.><0.05) The risk of severe impact of headache on quality of life (HIT-6) and migraine burden outside of attacks (MIBS-4) are also significantly higher in perimenopause than in RA (OR=1.9 and OR=1.7, respectively; p<0.05), and most quality of life indicators (SF-36) are lower (p><0.05). The risk of arterial hypertension and musculoskeletal diseases is higher in perimenopause than in RA (OR=2.8 and OR=4.25, respectively; p><0.05). The risk of clinically pronounced anxiety and insomnia is higher in perimenopause than in RA (OR=2.4 and OR=5.15; p><0.05). Conclusion. The course of migraine in women in perimenopause is less favorable than in RA. Further studies are needed to determine the causes of the observed phenomena and to develop clinical guidelines for the treatment of perimenopausal migraine patients.><0.05) ), and most quality of life indicators (SF-36) are lower (p<0.05). The risk of arterial hypertension and musculoskeletal diseases is higher in perimenopause than in RA (OR=2.8 and OR=4.25, respectively; p><0.05). The risk of clinically pronounced anxiety and insomnia is higher in perimenopause than in RA (OR=2.4 and OR=5.15; p><0.05). Conclusion. The course of migraine in women in perimenopause is less favorable than in RA. Further studies are needed to determine the causes of the observed phenomena and to develop clinical guidelines for the treatment of perimenopausal migraine patients.><0.05). The risk of arterial hypertension and musculoskeletal diseases is higher in perimenopause than in RA (OR=2.8 and OR=4.25, respectively; p<0.05). The risk of clinically pronounced anxiety and insomnia is higher in perimenopause than in RA (OR=2.4 and OR=5.15; p<0.05)

Conclusion. The course of migraine in women in perimenopause is less favorable than in RA. Further studies are needed to determine the causes of the observed phenomena and to develop clinical guidelines for the treatment of perimenopausal migraine patients.