bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemberlakuan Masa Iddah Isteri Bagi Suami Studi Di Kantor Urusan Agama Tawang Kota Tasikmalaya
Authors: Abduh Muhammad
Published: September 2024

Setelah Surat Edaran bahwa jika mantan suami  ingin menikah dengan istri lain setelah cerai harus menunggu  masa iddah berakhir dari mantan isterinya. Tujuan dalam penelitian ini ingin mengetahui bagaimana pelaksanaan Surat Edaran tersebut di Kantor Urusan Agama Tawang Kota Tasikmalaya dan bagaimana bila ada mantan suami yang belum selesai masa iddahnya apakah tetap bisa dilaksanakan pernikahannya. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan data observasi dan wawancara. Hasil  penelitian inii, Pertama, pihak Kantor Urusan Agama Tawang Kota Tasikmalaya menyambut baik adanya Surat Edaran tersebut, namun apabila ada mantan suami yang belum menyelesaikan masa iddah mantan isterinya pihak KUA menyarankan untuk mengikuti anjuran aturan Surat Edaran, tapi apabila ada mantan suami memaksa untuk dapat dilaksanakan pernikahannya sebelum selesai masa iddah maka pihak kantor memberikan dispensasi keringanan untuk membuat surat pernyataan. Kedua, tidak ada sanksi khusus bagi mantan suami dalam Surat Edaran apabila sebelum masa iddah isteri selesai dan perkawinannya tetap dapat dilaksanakan, namun apabila  ada hal-hal yang dilanggar dalam surat pernyatan yang telah dibuat maka konsekwensinya ditanggung sama yang bersangkutan.
Kontribusi Orang Tua Tentang Cara Anak Memahami Keberagaman Dalam Interaksi Sosial Anak Usia Dini
Authors: Anggraeni Ira
Published: September 2024

The aim of this study is to analyze the contribution of parents in helping children understand diversity in social interactions. This study uses a survey research method with a questionnaire data collection technique. From the results of the study, two major themes were found that are related to the contribution of parents in helping children understand diversity in social interactions of young children. The first theme is the awareness of parents about multiculturalism, which includes an understanding of cultural and value diversity in society, as well as a willingness to recognize and appreciate these differences. The second theme is the contribution of parents in the way children understand diversity in social interactions, which includes parental support in introducing children to social and cultural diversity, as well as facilitating positive experiences in social interactions involving cultural and value differences. Therefore, parents should play an active role in educating their children and ensure that they introduce their children to social and cultural diversity from an early age.
PENINGKATAN KEMAMPUAN KOGNITIF BERPIKIR SIMBOLIK ANAK USIA 5-6 TAHUN MELALUI KEGIATAN PERMAINAN EDUKATIF SMART CUBE
Authors: Lukmanul Hakim Oki
Published: September 2024

Perkembangan kognitif pada anak usia dini merupakan perubahan psikis yang berpengaruh terhadap kemampuan berpikir, Alat permainan edukatif merupakan media pembelajaran yang dibuat secara sengaja dirancang untuk pendidikan yang ditujukan membantu perkembangan anak APE Smart Cube salah satu alat permainan edukatif yang merupakan kegiatan pembelajaran tentang pengenalan angka, penjumlahan sederhana yang mudah dimainkan. Pembelajaran model eksisting jarang mengunakan APE sehingga anak tidak tertarik pada materi pembelajaran dan tidak termotivasi untuk mengikuti pembelajaran hal ini mengakibatkan hasil belajar anak rendah, hal tersebut dapat dilihat dari hasil observasi awal terhadap anak-anak mencapai persentase 26,2%. Oleh karena itu guru perlu menimbulkan aktivitas anak dengan kreatifitas yang menarik dan menyenangkan. Pendekatan penelitian yang diambil menggunakan model penelitian tindakan kelas. Pendekatan penelitian menggunakan model yang digunakan oleh Kurt Lewin yang dimulai dengan rencana, tindakan, pengamatan, refleksi. Subjek dalam penelitian ini adalah anak usia 5-6 tahun di TKA Nurul Huda yang berjumlah 12 orang. Adapun pengumpulan data dilakukan dengan teknik observasi, wawancara, dan dokumentasi. Berdasarkan dalam penelitian pada siklus I mendapatkan nilai sebesar 29,52%, pada siklus II dengan persentase 56,6% pada siklus III dengan persentase 83,3%. Sehingga dapat disimpulkan bahwa penggunaan pembelajaran menggunakan media pembelajaran dapat mempengaruhi anak usia 5-6 tahun dalam kemampuan kognitif berpikir simbolik anak
PENERAPAN MEDIA TEKA-TEKI BERGAMBAR UNTUK MENINGKATKAN KEMAMPUAN KEAKSARAAN ANAK KELOMPOK B USIA 5 – 6 TAHUN DI SPS TAAM ANNUUR
Authors: Adawiah Rida
Published: September 2024

Rendahnya kemampuan dalam aspek keaksaraan disebabkan oleh kurangnya kreativitas pendidik dalam pembelajaran mengenalkan huruf dan membaca kepada anak. Selain itu, kurang optimalnya pendidik SPS TAAM Annuur dalam pembelajaran mengenalkan huruf kepada anak yang selalu terpusat kepada pendidik, sehingga proses pembelajaran yang monoton dan membosankan bagi anak. Berdasarkan hasil observasi pada pra tindakan rata-rata nilai mencapai 32%. Penelitian ini bertujuan untuk mengidentitfikasi media teka teki bergambar dalam meningkatkan kemampuan keaksaraan anak kelompok B usia 5-6 tahun di SPS TAAM Annuur. Oleh sebab itu peneliti menggunakan media teka-teki bergambar untuk meningkatkan konsentrasi dalam memecahkan masalah, mengembangkan kemandirian pada anak serta menstimulasi minat belajar anak dalam mengenal keaksaraan pada anak kelompok B di SPS TAAM Annuur. Penelitian ini merupakan jenis Penelitian Tindakan Kelas (PTK) dengan model PTK Kurt Lewin. Subjek dalam penilitian ini adalah 10 anak kelompok B di SPS TAAM Annuur. Penelitian ini terdiri dari tiga siklus dengan tahapan perencanaan, pelaksanaan, pengamatan dan refleksi. Berdasarkan hasil penelitian pada siklus I, penilaian RPPH nilai persentase 63%. Dan penilaian pelaksanaan pembelajaran nilai persentase 70%. Pada siklus II dengan nilai persentase 80% dan penilaian pelaksanaan pembelajaran nilai persentase 72%. Pada siklus III, penilaian RPPH nilai persentase 89% dan penilaian pelaksanaan pembelajaran nilai persentase 88%. Peningkatan kemampuan keaksaraan anak dapat dilihat dari peningkatan rata-rata persentase yaitu dinyatakan berhasil jika mencapai nilai 80% dari jumlah anak yang memenuhi kriteria berkembang sangat baik. Kemudian melalui penerapan media teka teki bergambar pada siklus 1 terjadi peningkatan nilai rata-rata menjadi 53%. Pada silkus II terjadi peningkatan yang lebih signifikan dengan nilai rata-rata sebesar 67%. Pada siklus III kemampuan keaksaraan anak meningkat secara drastis dan mencapai indikator keberhasilan rata-rata nilai sebesar 83%. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa melalui penerapan media teka teki bergambar efektif dalam meningkatkan kemampuan keaksaraan anak di kelompok B SPS TAAM Annuur.
INTERNALISASI NILAI KEMANDIRIAN MELALUI PENDIDIKAN KEWIRAUSAHAAN
Authors: Ajang Ramdani
Published: September 2024

Penelitian ini bertujuan untuk menyelidiki bagaimana pendidikan kewirausahaan dapat memfasilitasi internalisasi nilai kemandirian di kalangan mahasiswa. Pendekatan pembelajaran yang aktif dan berbasis pengalaman, seperti simulasi bisnis dan proyek kewirausahaan, serta peran dosen dan mentor berpengalaman dalam mendukung proses ini, menjadi fokus utama. Melalui praktik bisnis simulasi, dan proyek kewirausahaan, mahasiswa dapat mengembangkan keterampilan mandiri yang diperlukan dalam merencanakan, mengelola, dan menjalankan bisnis. Kurikulum yang relevan dan terkini juga menjadi aspek penting dalam mempersiapkan mahasiswa untuk menghadapi dinamika bisnis yang kompleks. Penelitian ini menggunakan metode metode Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Temuan penelitian ini diharapkan dapat memberikan wawasan yang berharga bagi pengembangan pendidikan kewirausahaan yang lebih efektif dalam memfasilitasi internalisasi nilai kemandirian di kalangan mahasiswa.
Burnout in the Digital Age: Rethinking Workplace Culture for Well-Being and Retention
Authors: Westover Jonathan
Published: September 2024

This article explores how digital workplace cultures can enable or diminish employee burnout and retention. The article argues that the rise of constant digital connectivity has blurred boundaries between work and personal life, enabling overwork as the norm. Two key stressors exacerbated by digital workstyles - the inability to disconnect from work and information overload - are shown to directly contribute to burnout risks like emotional exhaustion. The impacts of burnout on individual well-being as well as organizational costs relating to disengagement, turnover and lost intellectual property are examined. The article then discusses how systemic culture change interventions focusing on boundary setting, workload management, supportive leadership and collective well-being can help companies address burnout by shifting priorities towards sustainable employee engagement.
Effectiveness of Using Online Single Submission Applications
Authors: Sutar Risti , Nasrullah Muh , Isgunandar
Published: September 2024

Effectiveness refers to how an organization successfully achieves its goals by measuring and assessing performance in carrying out tasks or activities. This study aims to evaluate how effective the use of the Online Single Submission Application is at the Office of the Investment and One-Stop Integrated Service of South Sulawesi Province. This study is important to identify factors that support or hinder the effectiveness of the use of the OSS application. The research method used is descriptive with a qualitative approach, which describes how the use of the OSS application takes place in the office. Data were collected through observation, interviews, and documentation. The study shows that the implementation of the Online Single Submission Application at the Office of the Investment and One-Stop Integrated Service of South Sulawesi Province was considered successful. Informants were satisfied with the clarity of the strategy for achieving goals, the quality of policy analysis, careful planning, the preparation of appropriate programs, and adequate work facilities. Good implementation, an effective monitoring system, and strict control also play a role in maintaining information security and preventing unauthorized access.
Ceftriaxone Utilization Pattern in Inpatient Department of Internal Medicine of a Tertiary Care Hospital
Authors: Yasmin S
Published: September 2024

Background: Antibiotic resistance becomes a global threat due to the rampant misuse and over use of antibiotics. Among themCeftriaxone is the most popular drug due its broad spectrum and low rates of toxicity and there is a prominent relationshipbetween the use of antimicrobial in hospital and its resistance. Therefore, close monitoring of ceftriaxone prescribing pattern isvery important to combat this resistance.

Objective: This study was conducted to identify the extent of Ceftriaxone use in internal medicine department of a tertiary carehospital.

Methods: A descriptive cross-sectional study was carried out through record review among 372 purposively selected patientsin internal medicine department of Dhaka Medical College from July 2018 to June 2019. All data were evaluated by WHOantibiotic guideline and BDNF and analyzed by SPSS.

Result: The proportion of Ceftriaxone use was 47.15%, RTI 10.22% was the most common indication for Ceftriaxone, 53.23%Ceftriaxone prescribed empirically, Metronidazole 22.67% was the most common co-administered drug, 22.58% prescriptionwas rational.

Conclusion: On the basis of the study findings it can be concluded that Ceftriaxone therapy is mostly empirical based.Respiratory tract infection is the common medical condition for ceftriaxone use. Metronidazole is the most commonlyprescribed co-administered antibiotic. Irrational use of ceftriaxone therapy is high.
TINJAUAN HUKUM TERHADAP PELANGGARAN HAK CIPTA KARYA DIGITAL CONTENT CREATOR DI INDONESIA
Authors: Lombok Lesza Leonardo , Tuwaidan Arthur , Takasana Veronika
Published: September 2024

Maraknya kasus-kasus pelanggaran hak cipta di era dunia digital ini yang dapat menimbulkan kerugian bagi pencipta Penelitian ini bertujuan untuk mengetahui bagaimana perlindungan hukum terhadap pelanggaran hak cipta karya digital content creator di Indonesia. Jenis penelitian yang digunakan dalam penelitian ini adalah Penelitian Hukum dengan menggunkan metode yang sesuai dengan karakteristik keilmuan dari ilmu hukum yaitu penelitian hukum normative. penelitian ini akan menggunakan pendekatan perundang-undangan (statute approach) dengan melakukan telaah secara mendalam berbagai peraturan perundang-undangan yang berkaitan dengan rumusan masalah dalam peraturan perundang-undangan. Hasil dari penelitian ini menunjukkan bahwa setiap pelanggaran atas hak cipta dari suatu karya digital yang diciptakan oleh Content Creator dapat dikenai sanksi pidana maupun perdata.
ANALISIS NILAI PENDIDIKAN KARAKTER DALAM SERAT WULANGREH KARYA SRI SUSUHUNAN PAKUBUWONO IV
Authors: Iskandar Maulana , Mukminin Amir
Published: September 2024

Sri Susuhunan Pakubuwono IV menuliskan petuah-petuah yang penuh dengan sarat makna nilai karakter di dalam serat Wulangreh. Penelitian konten yang didukung dengan analisis deskriptif ditempuh oleh peneliti untuk menganalisis bait-bait tembang yang menyiratkan beberapa nilai karakter dari 18 nilai karakter yang dicetuskan oleh Kementerian Pendidikan Nasional. Hasil penelitian menujukkan beberapa nilai yang terkandung di dalam serat Wulangreh yaitu, religius, cinta damai, kerja keras, cinta tanah air dan gemar membaca.
HARMONISASI NASIONALISME DALAM BINGKAI UKHUWAH ISLAMIYAH
Authors: Dwi Wahyuni Ruslina , Ahila Firdaus Royan , Rosyid Ridho Muhammad , Azizah Nuriana Mutia
Published: September 2024

Penulisan ini ingin mengkaji tentang nasinalisme dalam keberagaman etnis dan munculnya separatism di Indonesia dalam bingkai ukhuwah islamiyah. Nasionalisme merupakan hal yang mutlak wajib dimiliki oleh setiap warga negara. Nasionalisme dapat menumbuhkan rasa cinta tanah air kepada bangsa dan negara oleh setiap warga negara. Keberagaman yang ad di Indonesia mulai dari suku, bahasa, ras, agama dan kepercayaan menjadikan bangsa Indonesia sebagai salah satu negara paling majemuk didunia, dari hal ini dapat menjadi dua mata pisau apakah berdampak pada hal yang positif atau malah berdampak pada hal yang negatif. Metode yang digunakan dalam penulisan ini yaitu jenis riset kepustakaan (library research). Hasil penelitian ini adalah bagaimana bagaimana menyikapi keberagaman yang ada di Indonesia ini dengan berbagai perpektif salah satunya dalam bingkai ukhuwah islamiyah, dalam perpektif yang positif ketika keberagaman ini bisa dikembangkan dan diatur oleh regulasi yang jelas, akan berdampak pada tingkat atau taraf kehidupan masyarakat yang lebih meningkat, tetapi jika sebaliknya maka akan muncul paham-paham separatisme yang menentang setiap aturan yang telah dibuat oleh pemerintah yang tujuannya ingin menghancurkan integrasi bangsa yang telah kuat. Maka, implementasi sikap nasionalisme ini harus betul-betul dipraktekkan dalam kehidupan sehari-hari sehingga integrasi masyarakat akan tercapai sesuai dengan cita-cita bangsa Indonesia.
La notion d’établissement « déployé » élaborée par le Tribunal administratif du travail : conséquences juridiques et perspectives pour le travail précaire et atypique
Authors: Dehaibi Laura
Published: September 2024

Le lieu de travail est un point de départ fondamental pour l’application du droit québécois en matière de relations du travail, mais sa définition juridique demeure floue. Dans le présent article, l’auteure explore le concept d’établissement qui figure dans le Code du travail québécois et défend l’idée que l’absence d’une définition de l’établissement tenant compte des espaces concrets du travail crée des « zones grises » d’emploi qui tendent à exclure les travailleurs dits « précaires » et « atypiques ». Plus particulièrement, l’auteure étudie une décision récente du Tribunal administratif du travail ayant étendu la portée de l’établissement aux personnes en télétravail durant un conflit de travail dans un contexte postpandémique pour illustrer que la prise en considération de la réalité industrielle changeante, bien qu’elle soit nécessaire, continue de rencontrer de la résistance de la part des acteurs juridiques. Ce faisant, l’auteure soulève des questions relativement au principe de retenue judiciaire en droit administratif et à son incidence sur la protection de travailleurs en situation de précarité.
Análisis de las promociones de ventas en Internet: el caso de las agencias de viaje
Authors: Palazón Vidal Mariola , Sicilia Piñero María
Published: September 2024

Internet has transformed business activity for many products and services. The mere Internet presence is no longer sufficient. The development of a specific online positioning and a structured plan of activities have become necessary. The travel industry is one of the sectors that best represent how Internet has changed the former distribution and communication systems. The established business model has changed dramatically since the online travel agencies entered the market. These agencies coexist with traditional travel agencies that have started to operate online. Travel agencies are therefore facing a very high level of competitiveness as Internet has provided them tremendous potential for creating business opportunities. Travel agencies are using different communication tools in order to differentiate from competitors. Strong emphasis is being put on sale promotions since they have proven very efficient in persuading consumers online.However, despite of its impact on consumer decisions and loyalty, it is highly unknown how travel agencies are using this communication tool. Through a content analysis this study analyzes sales promotions of those agencies that operate exclusively online and of those who operate in traditional channels as well as online. Results reveal that traditional travel agencies are still adapting to the Internet, while online agencies show a slightly greater dynamism and develop shorter promotional campaigns than traditional travel agencies. In addition, most developed sales promotions focus on monetary incentives (mainly price cuts) rather than offering any other kind of non-monetary incentives. This study shows that Spanish travel agencies are not making use of the advantages the Internet could offer to this business in terms of promotional activity.
Age-related changes in “cortical” 1/f dynamics are linked to cardiac activity
Authors: Schmidt Fabian , Danböck Sarah K , Trinka Eugen , Klein Dominic P , Demarchi Gianpaolo , Weisz Nathan
Published: September 2024

The power of electrophysiologically measured cortical activity decays

1/f
X

. The slope of this decay (i.e. the spectral exponent) is modulated by various factors such as age, cognitive states or psychiatric/neurological disorders. Interestingly, a mostly parallel line of research has also uncovered similar effects for the spectral slope in the electrocardiogram (ECG). This raises the question whether these bodywide changes in spectral slopes are (in-)dependent. Focusing on well-established age-related changes in spectral slopes we analyzed a total of 1282 recordings of magnetoencephalography (MEG) resting state measurements with concurrent ECG in an age-diverse sample. We show that the aperiodic signal recorded using surface electrodes/sensors originates from multiple physiological sources. In particular, significant parts of age-related changes in aperiodic activity normally interpreted to be of neural origin can be explained by cardiac activity. Moreover, our results suggest that changes (flattening/steepening) of the spectral slope with age are dependent on the recording site and investigated frequency range. Our results highlight the complexity of aperiodic activity while raising concerns when interpreting aperiodic activity as “cortical“ without considering physiological influences.
Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation
Authors: Yamaguchi Nobutoshi , Yicong Wang , Abe Masato , Kadoya Yuka , Saiki Takeru , Imai Kanae , Wang Xuejing , To Taiko , Inagaki Soichi , Suzuki Takamasa , Kakutani Tetsuji , Ito Toshiro
Published: September 2024

Polycomb Repressive Complex 2 (PRC2) recognizes Polycomb response elements (PREs) and catalyzes trimethylation of histone H3 on lysine 27 (H3K27me3) for gene silencing. This silencing is counteracted by H3K36 methylation for epigenetic activation of gene expression. Here, we show that the
Arabidopsis thaliana
H3K36 methyltransferases SET DOMAIN-CONTAINING PROTEIN 7 (SDG7) and SDG8 antagonize PRC2-mediated silencing and establish H3K36 methylation patterns with the general transcription machinery. The
sdg7 sdg8
double mutant shows developmental defects and lower H3K36me2 and H3K36me3 levels. SDG7 preferentially binds near PREs, but SDG8 is recruited to H3K36 methylation peaks. The
sdg7 sdg8
phenotypes are partially rescued by loss of Polycomb function. SDG7 overlaps with PRC2 and its recruiters on chromatin and evicts them from shared target genes when conditionally induced. SDG8 and RNA Polymerase II associate at SDG- and RNA POLYMERASE II ASSOCIATED FACTOR 1 complex-regulated targets for H3K36 methylation and transcription. These results suggest that SDG proteins evict PRC2 from PREs to prevent H3K27me3 deposition and activate target genes via transcription-coupled H3K36 methylation.
Applied research won’t flourish without basic science
Authors: Lorsch Jon R , Tabak Lawrence A , Bertagnolli Monica M
Published: September 2024

Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.
A three filament mechanistic model of musculotendon force and impedance
Authors: Millard Matthew , Franklin David W , Herzog Walter
Published: September 2024

The force developed by actively lengthened muscle depends on different structures across different scales of lengthening. For small perturbations, the active response of muscle is well captured by a linear-time-invariant (LTI) system: a stiff spring in parallel with a light damper. The force response of muscle to longer stretches is better represented by a compliant spring that can fix its end when activated. Experimental work has shown that the stiffness and damping (impedance) of muscle in response to small perturbations is of fundamental importance to motor learning and mechanical stability, while the huge forces developed during long active stretches are critical for simulating and predicting injury. Outside of motor learning and injury, muscle is actively lengthened as a part of nearly all terrestrial locomotion. Despite the functional importance of impedance and active lengthening, no single muscle model has all these mechanical properties. In this work, we present the viscoelastic-crossbridge active-titin (VEXAT) model that can replicate the response of muscle to length changes great and small. To evaluate the VEXAT model, we compare its response to biological muscle by simulating experiments that measure the impedance of muscle, and the forces developed during long active stretches. In addition, we have also compared the responses of the VEXAT model to a popular Hill-type muscle model. The VEXAT model more accurately captures the impedance of biological muscle and its responses to long active stretches than a Hill-type model and can still reproduce the force-velocity and force-length relations of muscle. While the comparison between the VEXAT model and biological muscle is favorable, there are some phenomena that can be improved: the low frequency phase response of the model, and a mechanism to support passive force enhancement.
Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila
Authors: Ma Zhixin , Wang Wenshu , Yang Xiaojing , Rui Menglong , Wang Su
Published: September 2024

Stem cell niche is critical for regulating the behavior of stem cells. Drosophila neural stem cells (Neuroblasts, NBs) are encased by glial niche cells closely, but it still remains unclear whether glial niche cells can regulate the self-renewal and differentiation of NBs. Here, we show that ferritin produced by glia, cooperates with Zip13 to transport iron into NBs for the energy production, which is essential to the self-renewal and proliferation of NBs. The knockdown of glial ferritin encoding genes causes energy shortage in NBs via downregulating aconitase activity and NAD+ level, which leads to the low proliferation and premature differentiation of NBs mediated by Prospero entering nuclei. More importantly, ferritin is a potential target for tumor suppression. In addition, the level of glial ferritin production is affected by the status of NBs, establishing a bicellular iron homeostasis. In this study, we demonstrate that glial cells are indispensable to maintain the self-renewal of NBs, unveiling a novel role of the NB glial niche during brain development.
Robust estimation of cancer and immune cell-type proportions from bulk tumor ATAC-Seq data
Authors: Gabriel Aurélie AG , Racle Julien , Falquet Maryline , Jandus Camilla , Gfeller David
Published: September 2024

Assay for Transposase-Accessible Chromatin sequencing (ATAC-Seq) is a widely used technique to explore gene regulatory mechanisms. For most ATAC-Seq data from healthy and diseased tissues such as tumors, chromatin accessibility measurement represents a mixed signal from multiple cell types. In this work, we derive reliable chromatin accessibility marker peaks and reference profiles for most non-malignant cell types frequently observed in the micro-environment of human tumors. We then integrate these data into the EPIC deconvolution framework (Racle
et al
., 2017) to quantify cell-type heterogeneity in bulk ATAC-Seq data. Our EPIC-ATAC tool accurately predicts non-malignant and malignant cell fractions in tumor samples. When applied to a human breast cancer cohort, EPIC-ATAC accurately infers the immune contexture of the main breast cancer subtypes.
Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females
Authors: Yun Minsik , Kim Do-Hyoung , Ha Tal Soo , Lee Kang-Min , Park Eungyu , Knaden Markus , Hansson Bill S , Kim Young-Joon
Published: September 2024

In birds and insects, the female uptakes sperm for a specific duration post-copulation known as the ejaculate holding period (EHP) before expelling unused sperm and the mating plug through sperm ejection. In this study, we found that Drosophila melanogaster females shortens the EHP when incubated with males or mated females shortly after the first mating. This phenomenon, which we termed male-induced EHP shortening (MIES), requires Or47b+ olfactory and ppk23+ gustatory neurons, activated by 2-methyltetracosane and 7-tricosene, respectively. These odorants raise cAMP levels in pC1 neurons, responsible for processing male courtship cues and regulating female mating receptivity. Elevated cAMP levels in pC1 neurons reduce EHP and reinstate their responsiveness to male courtship cues, promoting re-mating with faster sperm ejection. This study established MIES as a genetically tractable model of sexual plasticity with a conserved neural mechanism.
PVN-mPFC OT projections modulates pup-directed pup care or attacking in virgin mandarin voles
Authors: Li Lu , Li Yin , Huang Caihong , Hou Wenjuan , Lv Zijian , Zhang Lizi , Qu Yishan , Sun Yahan , Huang Kaizhe , Han Xiao , He Zhixiong , Tai Fadao
Published: September 2024

In many species, adult animals may exhibit caregiving or aggression towards conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous virgin mandarin voles (
Microtus mandarinus
) that may exhibit pup care or infanticide, we found that more oxytocin (OT) neurons in the paraventricular nucleus (PVN) were activated during pup caring than infanticide. Optogenetic activation of OT neurons in the PVN facilitated pup-caring in male and female mandarin voles. In infanticide voles, optogenetic activation of PVN OT cells prolonged latency to approach and attack pups, whereas inhibition of these OT neurons facilitated approach and infanticide. In addition, OT release in the medial prefrontal cortex (mPFC) in pup-care voles increased upon approaching and retrieving pups, and decreased in infanticide voles upon attacking pups. Optogenetic activation of PVN OT neuron projections to the mPFC shortened the latency to approach and retrieve pups and facilitated the initiation of pup care, whereas inhibition of these projections had little effect. For pup-care females, neither activation nor inhibition of the fibers affected their behavior towards pups. In infanticide male and female voles, optogenetic activation of PVN-mPFC OT projection fibers prolonged the latency to approach and attack pups and suppressed the initiation of infanticide, whereas inhibition of these projections promoted approach and infanticide. Finally, we found that intraperitoneal injection of OT promoted pup care and inhibited infanticide behavior. It is suggested that the OT system, especially PVN OT neurons projecting to mPFC, modulates pup-directed behaviors and OT can be used to treat abnormal behavioral responses associated with some psychological diseases such as depression and psychosis.
Atrio Metropolitano: Plaza urbana vertical
Authors:   , Castro Esbir Damian
Published: September 2024

En el contexto del habitar metropolitano, desde principios del siglo XX se ha percibido un deterioro de los centros urbanos. Por un lado, causado por abruptos aumentos en la densidad poblacional, mientras que por otro, estos están amarrados a modelos económicos frenéticos y usualmente desregulados… Esto tiende a deteriorar los espacios públicos, volviéndolos lugares peligrosos y segregados. Este estado de crisis del centro retoma un problema que se ha discutido en arquitectura a lo largo del siglo XX y que ha generado muchas posturas y respuestas. Dado el vigente estado de crisis del centro de Santiago, donde la interacción en el espacio público con otros se reduce a un mínimo crítico, se vuelve fundamental la búsqueda de nuevos momentos de fricción que impulsen este sentido de pertenencia y de cohesión social en la comunidad, revalorizando el espacio público metropolitano y su condición urbana.Ante este problema y enmarcado dentro de los objetivos del taller, se formula la pregunta:¿De qué manera el atrio, como pieza arquitectónica, puede aportar a la condición urbana del suelo metropolitano, favoreciendo la densidad vertical?¿Puede el atrio, en su caracterización y forma, ser entendido como un espacio público continuo con una condición urbana propia?Se busca por medio de la investigación entregar una pieza que sirva como respuesta capaz de aportar al espacio público su condición urbana, entendiendo la importancia de una densidad metropolitana. Es por esto que se investiga el edificio híbrido y la reinvención del atrio como tipología capaz de verticalizar las relaciones públicas propias del espacio metropolitano, el contexto en el que aparece y cómo este cambia en los últimos 100 años. Buscando comprender los modos de relación del peatón con el edificio híbrido. De esta revisión, se plantea una exploración formal sobre el vaciado del cubo abstracto de 100x100x100 como representación del edificio híbrido con atrio como tipología capaz de verticalizar las relaciones propias del espacio público metropolitano. La exploración busca probar distintas operaciones de vaciado y deformaciones del sólido que nos permitan generar propuestas formales comparables donde se despliegue el suelo urbano que entendemos como plaza dentro de la verticalidad del atrio. Buscando generar un espacio público continuo que aproveche el vacío central para desplegar un suelo público en su vertical.
Bordes en degradación: el caso de la Estación de Biología Marina de Montemar
Authors:   , Prado Nielsen Domingo José
Published: September 2024

La costa del litoral chileno, al norte de Reñaca, ha sido objetivo de juicio por la relación que existe entre la arquitectura y su contexto, basado en conceptos culturales, sociales o económicos. A partir de la apariencia degradada que existe en un edificio de alto valor arquitectónico, como lo es la Estación de Biología Marina de Montemar, nace la inquietud por estudiar la relación que se produce entre la arquitectura y su contexto ecológico y por especular las posibilidades proyectuales que existen ante fenómenos naturales costeros. Tanto el programa como la forma se vuelven fundamentales en la agencia educativa que tiene la Estación para el lugar de Montemar y Cochoa, histórica y actualmente. El habitante y el océano Pacífico, específicamente en el contexto chileno, han estado relacionados tradicionalmente por la pesca y por el comercio marítimo. Independiente de esta función productiva, el conocimiento cultural que existe con respecto a la costa es precario para la inmensidad y complejidad que suponen los vastos kilómetros de océano que bordean el territorio. Los factores antrópicos que han supuesto un sacrificio para la ecología de Montemar marcan las prioridades en el proyecto arquitectónico para especular la relación de este con la naturaleza. La composición y materialidad de la Estación sirve como un vestigio del agotamiento de un proyecto que ha dialogado con su entorno como también opuesto resistencia. Desde el análisis histórico y formal del edificio se plantea estudiar cómo la arquitectura y naturaleza se han afectado mutuamente.
Dolor crónico en personas que tuvieron COVID-19 grave
Authors:   , Sepúlveda Caro Sofía Valeria
Published: September 2024

El contexto COVID ofrece un escenario en donde están presentes diferentes factores de riesgo para el desarrollo del dolor crónico: síndrome post-UCI, COVID-19 como morbilidad y factores psicológicos que se han visto intensificados producto de la pandemia. Así, el objetivo del estudio fue determinar la relación entre diferentes variables asociadas a la hospitalización en UCI y sintomatología psicológica en el desarrollo de dolor crónico en personas que tuvieron COVID-19 grave. 114 personas que fueron hospitalizadas en UCI por COVID-19 grave fueron evaluadas al momento del alta de UCI y tres meses después de esto; se realizaron análisis descriptivos y de regresión logística múltiple comparando a quienes presentaban dolor crónico vs. quienes no lo hacían. Los resultados indicaron una prevalencia del 58% de dolor crónico, junto con destacar la relación entre ansiedad, depresión y estrés postraumático en el desarrollo y mantención del dolor crónico. Lo anterior sugiere que es necesario comprender la trayectoria de recuperación después del alta en estos pacientes desde un enfoque biopsicosocial, de manera tal de contribuir a su calidad de vida y mermar los efectos de la hospitalización en ella, junto con replantearse el rol de la rehabilitación y cuidados posteriores de los pacientes.
Habilidades y competencias digitales e informacionales: ¿coadyuvantes de la docencia universitaria?
Authors: Ambriz Gerardo Sánchez , Hernández Adriana Yáñez , Ambriz M. Leticia Sánchez , Tinajero Pedro Guzmán , Thirión Rocío Fanny Cruz , Sánchez Claudia Cruz
Published: September 2024

La evolución de las diversas sociedades existentes en el mundo está sustentada en la evolución del conocimiento, la inteligencia y el saber de la Instituciones de Educación Superior, donde el personal docente aporta en sus procesos enseñanza-aprendizaje-investigación, significativos procesos cognitivos a los educandos, posibilitando una formación integral y competitiva; por tanto, el artículo tiene como propósito: Describir e identificar el nivel de desarrollo de las habilidades y, competencias digitales,  informacionales e investigativas en docentes universitarios; como una estrategia de evaluación sobre sus necesidades de apoyo metodológico y tecnológico, para el mejoramiento de los procesos enseñanza-aprendizaje (Acceso a la Información y Escritura Científica) en la docencia universitaria. La investigación es de tipo mixta (Métodos Deductivo-Analítico), con un alcance descriptivo, su diseño es no experimental (No se manipulan variables). Enfoque cuantitativo. El estudio denota la significativa aportación de los docentes, en la transferencia de conocimientos, para solucionar la problemática de los estudiantes en la adquisición de las habilidades y competencias digitales e informacionales para la búsqueda, localización, organización de la información como apoyo a sus procesos de enseñanza, aprendizaje e investigación con rigor científico, en su formación universitaria.
Evaluation of Behaviour of Child and Acceptance of Multicoloured and Conventional Composite Materials: A Split-mouth Randomised Clinical Study
Authors: Honaje Nilam Vitthalrao , Ninawe Nupur Suresh , Dolas Arti Rameshwar , Bahetwar Surendrakumar Kaluram , Anija CK , Joshi Suyash Sanjay
Published: September 2024

Introduction: The most crucial abilities for a Paediatric Dentist involve evaluating and managing children based on their behaviour. Children are often motivated to choose coloured restorative materials. They tend to hold their new fillings in high regard and are usually fascinated by the new materials in their oral cavity. Consequently, they are more likely to maintain the restoration, which greatly enhances their overall oral hygiene and fosters a favourable attitude towards therapy. Aim: To evaluate the behaviour of children and their acceptance of multicoloured and conventional composite materials: A randomised controlled trial. Materials and Methods: A split-mouth, single-blinded, randomised clinical study was conducted on 25 patients with Class I occlusal caries at the Department of Paediatric and Preventive Dentistry, Government Dental College and Hospital (GDCH), Nagpur, Maharashtra, India, from July 2023 to January 2024. Healthy children aged between 5 and 10 years, who were visiting the dentist for the first time, were selected from the Department of Paediatric and Preventive Dentistry. The chidren were divided in two groups-group 1, 13 (52%) children with blue coloured composite restorations and group 2, 12 (48%) chidren who received conventional composite restorations. Behaviour was assessed using the modified behaviour rating scale before and after treatment. Data analysis was performed using Statistical Package for Social Sciences (SPSS) software version 16.0 with the Wilcoxon’s Signed-rank Test. Results: Among total of 25 children, 14 (56%) were males and 11 (44%) were females with a mean age of 8.47±1.59 years. There was a significant improvement in the behaviour of children after treatment with blue coloured compomer (p-value<0.001), whereas the change in behaviour in the conventional composite group was non significant (p-value=0.157). Conclusion: Coloured restorative materials, such as blue compomer, show promising results in paediatric dentistry by promoting positive behaviour and satisfaction among children, potentially enhancing oral hygiene practices.
Adult Onset of Subacute Sclerosing Section Panencephalitis- A Case Report
Authors: Takalkar Kedar S , Raikar Pooja , Aradhey Parag R , Kinkar Jiwan
Published: September 2024

Subacute Sclerosing Panencephalitis (SSPE) is a rare, slowly progressive disorder that affects the entire nervous system. It primarily involves the cerebral cortex, subcortex and optic nerves. Caused by a mutated strain of the measles virus, the disease is mostly irreversible and devastating. It presents with gradually progressive cognitive impairment, extrapyramidal symptoms and sometimes seizures. Although commonly seen in unvaccinated children, SSPE of adult onset is uncommon. The disease is fatal and currently has no treatment. There have been many different presentations of this disorder, ranging from optic nerve involvement to gradual cognitive decline, but none have a good prognosis; ultimately, patients may become akinetic and mute. Here, the authors present an uncommon case of SSPE occurring at an older age (26-year-old male), with a rapid and atypical presentation resembling severe post-viral syndrome, which was later diagnosed as SSPE.
Living Hedges and Household Food and Nutrition Security in Cote D'ivoire
Authors: Gniza Innocent Daniel , Ouattara Kifory
Published: September 2024

Soil degradation is a major problem, particularly for Ivorian rice farmers who grow rainfed rice on slopes or flood plains. To remedy this situation, some households are adopting agroforestry practices, in particular living hedgerows. This study analyzes the economic impact of the adoption of living hedgerows on the food and nutritional security of rice-growing households in Côte d'Ivoire. Data were collected from 456 households in the regions of Tonkpi in the west, Poro and Tchologo in the north, using stratified random sampling, with each village considered as a stratum. Then, the two steps of the propensity score matching (PSM) method were used to identify the factors involved in the adoption of living hedges and to measure the effect of this adoption on household food and nutritional security. The results obtained from the propensity score matching (PSM) analysis indicate that the adoption of living hedges improves the food and nutritional security of adopters by an average of 67% and 266.67% respectively. The study therefore recommends improving human capital through training in rice plot selection, raising awareness of the benefits of agroforestry practices, and capacity-building for producers in the use of living hedgerows.
Antilipidemic Effect of Ethanolic Extract of Aloe barbadensis Gel, Cymbopogon citratus Leaves and Its Combination on Alloxan Induced Diabetic Rats
Authors: V. O. Offor, , A. N. Ufele, , B. U. Ononye, , E. I. Azaka, , C. O. Ishar, , P. K. Okafor, , P. I. Afoemezie,
Published: September 2024

This research sought to investigate the antilipidemic effect of ethanolic extract of Aloe barbadensis, Cymbopogon citratus leaves and its equal combination on induced-alloxan diabetic rat. Plants like Aloe barbadensis and Cymbopogon citratus are commonly used as home remedies for some diseases such as diabetes thereby making them alternative medicines. Ethanolic extract of both plants was extracted using 70% ethanol. The effect of glibenclamide, ethanolic extract of A. barbadensis gel, C. citratus leaves and its combination after 21 days experimental study showed a significantly increased (P<0.05) high density lipoprotein (HDL) in the induced rats when in comparison with the normal control and diabetic untreated rats. The low density lipoprotein (LDL) significantly showed a (P<0.05) decrease in the rats treated with A. barbadensis gel, C. citratus leaves and its combined extract compared with those treated with standard drug. The serum total cholesterol (TCHOL), triglyceride (TG) and very low density lipoprotein (VLDL) significantly showed a (P<0.05) decrease in the rats treated with A. barbadensis gel, C. citratus leaves and its combined extract compared with diabetic untreated rats. This research revealed that ethanolic extract of A. barbadensis, C. citratus and its combination has antilipidemic effects and holds potential as an alternative therapy for its management.
Phytochemical Analysis, Antioxidant Properties, Anti-nutrient Contents and Antimicrobial Study of Aqueous Extract of Morinda lucinda, Solanum erianthun, and Dryopteris expansa
Authors: A. S. Gbadamosi , M.O. Oseni , O.A. Oseni
Published: September 2024

The emergence of antibiotic-resistant microorganisms poses a significant challenge in clinical practice by complicating treatment options for infections. Exploring natural products as alternative drugs presents a promising approach to addressing these issues. Medicinal plants, acknowledged by the World Health Organization (WHO) as a preferred and safest source of various medicines, have gained considerable attention. Therefore, this study was conducted to investigate the phytochemical constituents, antioxidant properties, anti-nutrient content, and antimicrobial activities of Morinda lucinda, Solanum erianthun, and Dryopteris expansa The phytochemical analysis indicates that while flavonoids, saponins, and reducing sugars are common across the studied plants, Morinda lucida and Dryopteris expansa exhibit higher levels of saponins and the present of alkaloids, suggesting potential unique medicinal properties. The antimicrobial study revealed that the aqueous leaf extract of Morinda lucida made Streptococcus pyogenes and Staphylococcus aureus susceptible to its effects, while Dryopteris expansa made only Streptococcus pyogenes susceptible and the aqueous leaf extract of Solanum erianthum made the fungal species Penicillium chrysogenum susceptible to its action. All the studied plants demonstrated very strong antioxidant activity. The anti-nutrient analysis showed that Morinda lucida had the lowest cyanide content at 5.50 mg/100 g, while Solanum erianthum had the highest cyanide content at 6.89 mg/100 g. Dryopteris expansa exhibited the lowest levels of oxalates and phytates, with values of 0.28 mg and 0.20%, respectively. The results of this study demonstrate that each of these plants possesses significant potential as antimicrobial agents and antioxidants, with low toxicity levels. Consequently, they hold promise for medicinal applications and drug development.
A Case Study on Investigation of Physico-chemical Properties of Dal Lake, Kashmir, India
Authors: Parvaiz Azifa , Abubakr Adnan , Malik Monisa , Bhat Farooz A. , Bhat Bilal Ahmad , Shah Tasaduq H. , Yousuf Zarka
Published: September 2024

Water quality is a key factor in determining the current condition of the freshwater ecosystem. The current analysis was conducted to assess the water quality status of Dal Lake. The lake was researched for 12 months, from March 2021 to February 2022, and a total of 17 physicochemical parameters were analysed at seven distinct sites at monthly intervals using established methodologies. The measured characteristics included air temperature (6.1°C-37.5°C) and water temperature (1.41°C-28.3°C), depth (1.1-3.1m), Secchi Disc transparency (0.3m-1.9m), specific conductivity (201 μScm-1-364 μScm-1), pH (7-7.9), Dissolved oxygen (4.4-9.2 mg/l), chloride (10-35 mg/l), free carbon dioxide (1.5-18.9 mg/l), total hardness (112-180 mg/l), calcium hardness (27.4-54.9 mg/l), magnesium hardness (17.4-31.8 mg/l), ammonia nitrogen (125-497 μg/l), nitrate-nitrogen (324-782 μg/l), nitrite-nitrogen (10-72 μg/l), orthophosphate (58-194 μg/l), and total phosphorus ranged from 193-568 μg/l. The investigation revealed that almost all of the above parameters indicate that the pollution load is increasing due to anthropogenic pressure, untreated sewage and solid garbage from residential areas, and fertilisers containing nitrates and phosphates, all of which have contributed to the lake's eutrophic condition. As a result, prompt protective measures should be implemented to prevent further depletion.