bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Optimizing the Design and Geometry of T Cell–Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer
Authors: Elsayed Abdullah , Plüss Louis , Nideroest Larissa , Rotta Giulia , Thoma Marina , Zangger Nathan , Peissert Frederik , Pfister Stefanie K. , Pellegrino Christian , Dakhel Plaza Sheila , De Luca Roberto , Manz Markus G. , Oxenius Annette , Puca Emanuele , Halin Cornelia , Neri Dario
Published: July 2024

Abstract
Metastatic colorectal cancer remains a leading cause of cancer-related deaths, with a 5-year survival rate of only 15%. T cell–engaging bispecific antibodies (TCBs) represent a class of biopharmaceuticals that redirect cytotoxic T cells toward tumor cells, thereby turning immunologically “cold” tumors into “hot” ones. The carcinoembryonic antigen (CEA) is an attractive tumor-associated antigen that is overexpressed in more than 98% of patients with colorectal cancer. In this study, we report the comparison of four different TCB formats employing the antibodies F4 (targeting human CEA) and 2C11 (targeting mouse CD3ε). These formats include both antibody fragment–based and IgG-based constructs, with either one or two binding specificities of the respective antibodies. The 2 + 1 arrangement, using an anti-CEA single-chain diabody fused to an anti-CD3 single-chain variable fragment, emerged as the most potent design, showing tumor killing at subnanomolar concentrations across three different CEA+ cell lines. The in vitro activity was three times greater in C57BL/6 mouse colon adenocarcinoma cells (MC38) expressing high levels of CEA compared with those expressing low levels, highlighting the impact of CEA density in this assay. The optimal TCB candidate was tested in two different immunocompetent mouse models of colorectal cancer and showed tumor growth retardation. Ex vivo analysis of tumor infiltrates showed an increase in CD4+ and CD8+ T cells upon TCB treatment. This study suggests that bivalent tumor targeting, monovalent T-cell targeting, and a short spatial separation are promising characteristics for CEA-targeting TCBs.
Data from Ultrasensitive Response Explains the Benefit of Combination Chemotherapy Despite Drug Antagonism
Authors: Patterson Sarah C. , Pomeroy Amy E. , Palmer Adam C.
Published: July 2024

Abstract
Most aggressive lymphomas are treated with combination chemotherapy, commonly as multiple cycles of concurrent drug administration. Concurrent administration is in theory optimal when combination therapies have synergistic (more than additive) drug interactions. We investigated pharmacodynamic interactions in the standard 4-drug “CHOP” regimen in peripheral T-cell lymphoma (PTCL) cell lines and found that CHOP consistently exhibits antagonism and not synergy. We tested whether staggered treatment schedules could improve tumor cell kill by avoiding antagonism, using in vitro models of concurrent or staggered treatments. Surprisingly, we observed that tumor cell kill is maximized by concurrent drug administration despite antagonistic drug–drug interactions. We propose that an ultrasensitive dose response, as described in radiology by the linear–quadratic (LQ) model, can reconcile these seemingly contradictory experimental observations. The LQ model describes the relationship between cell survival and dose, and in radiology has identified scenarios favoring hypofractionated radiotherapy—the administration of fewer large doses rather than multiple smaller doses. Specifically, hypofractionated treatment can be favored when cells require an accumulation of DNA damage, rather than a “single hit,” to die. By adapting the LQ model to combination chemotherapy and accounting for tumor heterogeneity, we find that tumor cell kill is maximized by concurrent administration of multiple drugs, even when chemotherapies have antagonistic interactions. Thus, our study identifies a new mechanism by which combination chemotherapy can be clinically beneficial that is not contingent on positive drug–drug interactions.
Supplementary Table S6 from Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I.
Published: July 2024

Human Oligonucleotides
Supplementary Table S8 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

Supplemental Table 8: Analysis of ETS1 ectopic expression
Supplementary Table S2 from Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I.
Published: July 2024

Upregulated canonical pathways in LG-, PRI- and REC-GVC
Supplementary Figure S7 from Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I.
Published: July 2024

Supplementary Figure S7. ASPN inhibits wIDH GBM growth via modulation of TGFΒ1-GPM6A signaling
Supplementary Figure S1 from Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth
Authors: Muthukrishnan Sree Deepthi , Qi Haocheng , Wang David , Elahi Lubayna , Pham Amy , Alvarado Alvaro G. , Li Tie , Gao Fuying , Kawaguchi Riki , Lai Albert , Kornblum Harley I.
Published: July 2024

Supplementary Figure S1. Characterization of cultured GVC
Supplementary Data: Video 4 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

ES-5838-CRISPR-ETS1a
Supplementary Data: Video 3 from ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Authors: Ebegboni Vernon Justice , Jones Tamara L. , Brownmiller Tayvia , Zhao Patrick X. , Pehrsson Erica C. , Sundara Rajan Soumya , Caplen Natasha J.
Published: July 2024

ES-5838-dCas9-VP64
Supplementary Table S1 from Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway
Authors: Zhong Ying , Kang Hui , Ma Ziqing , Li Jiayu , Qin Zixi , Zhang Zixuan , Li Peiwen , Zhong Ying , Wang Lihui
Published: July 2024

Primer sets for qRT-PCR
Supplementary Table 3 from Nfe2l2/NRF2 Deletion Attenuates Tumorigenesis and Increases Bacterial Diversity in a Mouse Model of Lynch Syndrome
Authors: Haller Felix , Jimenez Kristine , Baumgartner Maximilian , Lang Michaela , Klotz Anton , Jambrich Manuela , Busslinger Georg , Müllauer Leonhard , Khare Vineeta , Gasche Christoph
Published: July 2024

Supplementary Table 3: Number of fecal stool samples at 1 month, 5 and 10 months of each genotype.
Supplementary Figure 1 from Nfe2l2/NRF2 Deletion Attenuates Tumorigenesis and Increases Bacterial Diversity in a Mouse Model of Lynch Syndrome
Authors: Haller Felix , Jimenez Kristine , Baumgartner Maximilian , Lang Michaela , Klotz Anton , Jambrich Manuela , Busslinger Georg , Müllauer Leonhard , Khare Vineeta , Gasche Christoph
Published: July 2024

Supplementary Figure 1: Characterization of MSH2ΔIECNrf2null, MSH2ΔIEC, and Nrf2null mice and tumor incidence between gender.
Supplementary Figure 5 from Melanoma Clonal Heterogeneity Leads to Secondary Resistance after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes
Authors: König David , Sandholzer Michael T. , Uzun Sarp , Zingg Andreas , Ritschard Reto , Thut Helen , Glatz Katharina , Kappos Elisabeth A. , Schaefer Dirk J. , Kettelhack Christoph , Passweg Jakob R. , Holbro Andreas , Baur Katharina , Medinger Michael , Buser Andreas , Lardinois Didier , Jeker Lukas T. , Khanna Nina , Stenner Frank , Kasenda Benjamin , Homicsko Krisztian , Matter Matthias , Rodrigues Mantuano Natalia , Zippelius Alfred , Läubli Heinz
Published: July 2024

Supplementary Figure 5. Reactivity assay of TIL product to the primary tumor. CD3+ T cells from the TIL product were tested for intracellular cytokine upregulation against a tumor cell line (TCL) derived from the resected lesion. Anti-CD3/CD28 stimulation was used as positive control. As a negative control, we used HLA blockade.
Supplementary Figure 4 from Melanoma Clonal Heterogeneity Leads to Secondary Resistance after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes
Authors: König David , Sandholzer Michael T. , Uzun Sarp , Zingg Andreas , Ritschard Reto , Thut Helen , Glatz Katharina , Kappos Elisabeth A. , Schaefer Dirk J. , Kettelhack Christoph , Passweg Jakob R. , Holbro Andreas , Baur Katharina , Medinger Michael , Buser Andreas , Lardinois Didier , Jeker Lukas T. , Khanna Nina , Stenner Frank , Kasenda Benjamin , Homicsko Krisztian , Matter Matthias , Rodrigues Mantuano Natalia , Zippelius Alfred , Läubli Heinz
Published: July 2024

Supplementary Figure 4. Progressing lung metastasis (Wedge resection 61 weeks after TIL transfer). The resected lung metastasis is Melan-A positive without any desmoplastic component.
Supplementary Fig. S7 from Small Extracellular Vesicle piR-hsa-30937 Derived from Pancreatic Neuroendocrine Neoplasms Upregulates CD276 in Macrophages to Promote Immune Evasion
Authors: Zhong Yuan , Tian Ye , Wang Yan , Bai Jian’an , Long Qin , Yan Lijun , Gong Zhihui , Gao Wei , Tang Qiyun
Published: July 2024

Supplementary Fig. S7 The RIP assay was conducted in THP-1 macrophages incubated with 10 µg/ml PNEN cell-derived sEVs for 48 h. Results showed no significant relative enrichment of piR-hsa-30937 by anti-PTEN.
Supplementary Table S9 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Table S9
Supplementary Table S8 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Table S8
Supplementary Figure S6 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S6. Characterization of MOLM-13 clones.
Supplementary Figure S4 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S4. MP0533 induces similar low cytokine release with pan T or PBMC as effector cells.
Supplementary Figure S2 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S2. MP0533 affinity traces and simultaneous binding to its targets.
Supplementary Figure S13 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S13. MP0533 safety profile in hPBMC mouse model xenografted intravenously with MOLM-13 cells.
Supplementary Figure 9 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig. S9. SIRT3 deficiency leads to more efficient TFH cell differentiation in infection and tumor via cell-intrinsic mechanisms.
Supplementary Figure S1 from The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
Authors: Bianchi Matteo , Reichen Christian , Croset Amelie , Fischer Stefanie , Eggenschwiler Aline , Grübler Yvonne , Marpakwar Rajlakshmi , Looser Thamar , Spitzli Patricia , Herzog Christel , Villemagne Denis , Schiegg Dieter , Abduli Liridon , Iss Chloé , Neculcea Alexandra , Franchini Marco , Lekishvili Tamara , Ragusa Simone , Zitt Christof , Kaufmann Yvonne , Auge Alienor , Hänggi Martin , Ali Waleed , Frasconi Teresa M. , Wullschleger Stephan , Schlegel Iris , Matzner Mirela , Lüthi Ursina , Schlereth Bernd , Dawson Keith M. , Kirkin Vladimir , Ochsenbein Adrian F. , Grimm Sebastian , Reschke Nina , Riether Carsten , Steiner Daniel , Leupin Nicolas , Goubier Anne
Published: July 2024

Supplementary Fig. S1. MP0533 format comparison.
Supplementary Figure 4 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig.S4.TFH cell differentiation and GC reactions induced by SIRT3 deficiency in mice.
Supplementary Table 3 from Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers
Authors: Praharaj Monali , Shen Fan , Lee Alex J. , Zhao Liang , Nirschl Thomas R. , Theodros Debebe , Singh Alok K. , Wang Xiaoxu , Adusei Kenneth M. , Lombardo Kara A. , Williams Raekwon A. , Sena Laura A. , Thompson Elizabeth A. , Tam Ada , Yegnasubramanian Srinivasan , Pearce Edward J. , Leone Robert D. , Alt Jesse , Rais Rana , Slusher Barbara S. , Pardoll Drew M. , Powell Jonathan D. , Zarif Jelani C.
Published: July 2024

Supplementary Table 3
Supplementary Legends from Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers
Authors: Praharaj Monali , Shen Fan , Lee Alex J. , Zhao Liang , Nirschl Thomas R. , Theodros Debebe , Singh Alok K. , Wang Xiaoxu , Adusei Kenneth M. , Lombardo Kara A. , Williams Raekwon A. , Sena Laura A. , Thompson Elizabeth A. , Tam Ada , Yegnasubramanian Srinivasan , Pearce Edward J. , Leone Robert D. , Alt Jesse , Rais Rana , Slusher Barbara S. , Pardoll Drew M. , Powell Jonathan D. , Zarif Jelani C.
Published: July 2024

Supplementary file containing the figure legends for each of the supplemental figures.
Supplementary Figure 6 from Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers
Authors: Praharaj Monali , Shen Fan , Lee Alex J. , Zhao Liang , Nirschl Thomas R. , Theodros Debebe , Singh Alok K. , Wang Xiaoxu , Adusei Kenneth M. , Lombardo Kara A. , Williams Raekwon A. , Sena Laura A. , Thompson Elizabeth A. , Tam Ada , Yegnasubramanian Srinivasan , Pearce Edward J. , Leone Robert D. , Alt Jesse , Rais Rana , Slusher Barbara S. , Pardoll Drew M. , Powell Jonathan D. , Zarif Jelani C.
Published: July 2024

Supplementary Figure 6
Supplementary Figure 14 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig.S14. Oxidative phosphorylation is required for TFH differentiation induced by Sirt3∆CD4.
Supplementary Figure 12 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig.S12. SIRT3 deficiency enhances TFH cell differentiation in vitro.
Supplementary Figure 10 from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Fig.S10. SIRT3 is required for promoting TFH differentiation and GC responses in vivo.
Figure 5 from Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers
Authors: Praharaj Monali , Shen Fan , Lee Alex J. , Zhao Liang , Nirschl Thomas R. , Theodros Debebe , Singh Alok K. , Wang Xiaoxu , Adusei Kenneth M. , Lombardo Kara A. , Williams Raekwon A. , Sena Laura A. , Thompson Elizabeth A. , Tam Ada , Yegnasubramanian Srinivasan , Pearce Edward J. , Leone Robert D. , Alt Jesse , Rais Rana , Slusher Barbara S. , Pardoll Drew M. , Powell Jonathan D. , Zarif Jelani C.
Published: July 2024

JHU083-induced glutamine antagonism affects tumor cell metabolism and induces cell death in urologic tumors. A, Log-fold changes of glutamine utilizing enzymes after JHU083 treatment vs. control tumors in CD45− sorted cells from B6CaP tumors, followed by scRNA-seq. B, Western blot showing qualitative changes in the levels of glutamine synthesizing/utilizing enzymes and transporters in the CD45− fraction of MB49 tumors. C, Percentage of GLUT1+ CD45− live cells determined by flow cytometry in B6CaP tumors (n = 7/group). D, Targeted metabolomic analysis of B6CaP tumors by LC-MS/MS (n = 3/group). E, Volcano plot showing key metabolite levels of JHU083-treated vs. nontreated control tumors based on the metabolomic analysis shown in D. F, Absolute quantification of metabolites by LC/MS-MS (n = 3 or 5/group). G and H, Western blot images showing qualitative changes in c-MYC, phospho-c-MYC, and HIF-1ɑ in MB49 tumors following JHU083 treatment, and (H and I) MTT assay in DON-treated MB49 cells and immunoblot of cleaved caspase 3 quantification in CD45− fraction MB49 tumors (J). Statistical analyses were performed using the unpaired t test. (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).
Figure 4 from Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers
Authors: Praharaj Monali , Shen Fan , Lee Alex J. , Zhao Liang , Nirschl Thomas R. , Theodros Debebe , Singh Alok K. , Wang Xiaoxu , Adusei Kenneth M. , Lombardo Kara A. , Williams Raekwon A. , Sena Laura A. , Thompson Elizabeth A. , Tam Ada , Yegnasubramanian Srinivasan , Pearce Edward J. , Leone Robert D. , Alt Jesse , Rais Rana , Slusher Barbara S. , Pardoll Drew M. , Powell Jonathan D. , Zarif Jelani C.
Published: July 2024

JHU083-induced glutamine antagonism caused a divergent metabolic response affecting glycolysis, purine metabolism, and succinate in TAMs. A and B, Surface and intracellular expression of GLUT1 and HKII (percentage positive population and mean fluorescence intensity) on B6CaP-derived TAMs. C, GSEA showing the enrichment of the Hallmark glycolysis gene set among DEGs in bulk RNA-sequenced FACS-sorted B6CaP-derived TAMs following JHU083 treatment relative to control. D, Heat map showing the differential metabolites in TAMs sorted from JHU083-treated and control B6CaP tumors (n = 3/group). E, Volcano plot showing log2 fold change vs. –log10 (FDR-corrected P value), representing fold changes in metabolite abundance in one-carbon metabolism, purine nucleotide metabolism, and hexosamine pathway in JHU083-treated vs. control TAMs. F, Normalized relative labeled metabolites from U-13C glucose in the TCA cycle in TAMs derived from B6CaP tumors (n = 9/group in two independent experiments). G, Normalized relative metabolite abundances in the TCA cycle in TAMs derived from B6CaP tumors (n = 9/group from two independent experiments) and (H) log fold-change of TCA cycle enzymes and inflammatory cytokine transcripts in TAMs (from scRNA-seq at an early time point (day 7 posttreatment). DEGs for GSEA in C were calculated with DESeq2, and statistics on genes of interest in H were calculated with the Wilcoxon rank-sum test. All other statistical analyses were performed using the unpaired t test (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).
Supplementary Tables from IL3-Driven T Cell–Basophil Crosstalk Enhances Antitumor Immunity
Authors: Wei Jian , Mayberry Colleen L. , Lv Xiaoting , Hu Fangyan , Khan Taushif , Logan Natalie A. , Wilson John J. , Sears John D. , Chaussabel Damien , Chang Chih-Hao
Published: July 2024

Supplementary Tables
Figure S7 from IL3-Driven T Cell–Basophil Crosstalk Enhances Antitumor Immunity
Authors: Wei Jian , Mayberry Colleen L. , Lv Xiaoting , Hu Fangyan , Khan Taushif , Logan Natalie A. , Wilson John J. , Sears John D. , Chaussabel Damien , Chang Chih-Hao
Published: July 2024

Association of Il-3, tumor-resident basophils, and Il-4 with cancer patient outcomes
Figure S5 from IL3-Driven T Cell–Basophil Crosstalk Enhances Antitumor Immunity
Authors: Wei Jian , Mayberry Colleen L. , Lv Xiaoting , Hu Fangyan , Khan Taushif , Logan Natalie A. , Wilson John J. , Sears John D. , Chaussabel Damien , Chang Chih-Hao
Published: July 2024

Identification of the cellular targets of IL3
Supplementary Tables from PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors
Authors: Alteber Zoya , Cojocaru Gady , Granit Roy Z. , Barbiro Inbal , Wool Assaf , Frenkel Masha , Novik Amit , Shuchami Adi , Liang Yu , Carmi Vered D. , Sabath Niv , Foreman Rob , Petrenko Natalia , He Jiang , Kliger Yossef , Levy-Barda Adva , Eitan Ram , Raban Oded , Sadot Eran , Sulimani Omri , Nathan Abraham Avi , Adewoye Henry , Ferre Pierre , Levine Zurit , Ophir Eran
Published: July 2024

Supplementary Tables 1-8
Supplementary Methods File 1 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Methods File 1. Modified eTAT delivery system based on SpyLigase and corresponding formulations for vaccination.
Supplementary Fig. S9 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S9. Evaluation of uptake of different GP33-related Ags and CpG in DC2.4 cells.
Supplementary Fig. S6 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S6. Flow cytometry gating strategy for CD8 T cell responses and evaluation of cytokine production against OVA.
Supplementary Fig. S24 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S24. Expression levels of PD-L1 on MC38 tumor cells.
Supplementary Fig. S19 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S19. Evaluation of H-2Db and PD-L1 expression of tumor cells in tumor microenvironment.
Supplementary Fig. S16 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S16. Body weight of B16-GP33 tumor-bearing mice treated with various formulations.
Supplementary Fig. S10 from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Supplementary Fig. S10. Evaluation of maturation of BMDCs following treatment with different GP33 formulations.
Data from SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer
Authors: Hou Yueru , Cao Yejin , He Ying , Dong Lin , Zhao Longhao , Dong Yingjie , Niu Ruiying , Bi Yujing , Liu Guangwei
Published: July 2024

Abstract
Follicular helper T (TFH) cells are essential for inducing germinal center (GC) reactions to mediate humoral adaptive immunity in tumors; however, the mechanisms underlying TFH-cell differentiation remain unclear. In this study, we found that the metabolism sensor sirtuin 3 (SIRT3) is critical for TFH-cell differentiation and GC formation during tumor development and viral infection. SIRT3 deficiency in CD4+ T cells intrinsically enhanced TFH-cell differentiation and GC reactions during tumor development and viral infection. Mechanistically, damaged oxidative phosphorylation (OXPHOS) compensatively triggered the NAD+–glycolysis pathway to provide a cellular energy supply, which was necessary for SIRT3 deficiency–induced TFH-cell differentiation. Blocking NAD+ synthesis–glycolysis signaling or recovering OXPHOS activities reversed the TFH-cell differentiation induced by SIRT3 deficiency. Moreover, the mTOR and hypoxia-inducible factor 1α (HIF1α) signaling axis was found to be responsible for TFH-cell differentiation induced by SIRT3 deficiency. HIF1α directly interacted with and regulated the activity of the transcription factor Bcl6. Thus, our findings identify a cellular energy compensatory mechanism, regulated by the mitochondrial sensor SIRT3, that triggers NAD+-dependent glycolysis during mitochondrial OXPHOS injuries and an mTOR–HIF1α–Bcl6 pathway to reprogram TFH-cell differentiation. These data have implications for future cancer immunotherapy research targeting SIRT3 in T cells.
Data from PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell–Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors
Authors: Alteber Zoya , Cojocaru Gady , Granit Roy Z. , Barbiro Inbal , Wool Assaf , Frenkel Masha , Novik Amit , Shuchami Adi , Liang Yu , Carmi Vered D. , Sabath Niv , Foreman Rob , Petrenko Natalia , He Jiang , Kliger Yossef , Levy-Barda Adva , Eitan Ram , Raban Oded , Sadot Eran , Sulimani Omri , Nathan Abraham Avi , Adewoye Henry , Ferre Pierre , Levine Zurit , Ophir Eran
Published: July 2024

Abstract
Cancers that are poorly immune infiltrated pose a substantial challenge, with current immunotherapies yielding limited clinical success. Stem-like memory T cells (TSCM) have been identified as a subgroup of T cells that possess strong proliferative capacity and that can expand and differentiate following interactions with dendritic cells (DCs). In this study, we explored the pattern of expression of a recently discovered inhibitory receptor poliovirus receptor-related immunoglobulin domain protein (PVRIG) and its ligand, poliovirus receptor-related ligand 2 (PVRL2), in the human tumor microenvironment. Using spatial and single-cell RNA transcriptomics data across diverse cancer indications, we found that among the T-cell checkpoints, PVRIG is uniquely expressed on TSCM and PVRL2 is expressed on DCs in immune aggregate niches in tumors. PVRIG blockade could therefore enhance TSCM–DC interactions and efficiently drive T-cell infiltration to tumors. Consistent with these data, following PVRIG blockade in patients with poorly infiltrated tumors, we observed immune modulation including increased tumor T-cell infiltration, T-cell receptor (TCR) clonality, and intratumoral T-cell expansion, all of which were associated with clinical benefit. These data suggest PVRIG blockade as a promising strategy to induce potent antitumor T-cell responses, providing a novel approach to overcome resistance to immunotherapy in immune-excluded tumors.
Data from Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting Cells by Using an Engineered Chimeric Peptide Enhances Antitumor T-Cell Immunity
Authors: Pan Haifeng , Yu Siyuan , Zhuang Haoyun , Yang Han , Jiang Jinlu , Yang Haihui , Ren Shuling , Luo Guoxing , Yu Xuan , Chen Shuping , Lin Yanhua , Sheng Roufang , Zhang Shiyin , Yuan Quan , Huang Chenghao , Zhang Tianying , Li Tingdong , Ge Shengxiang , Zhang Jun , Xia Ningshao
Published: July 2024

Abstract
The intrinsic pharmacokinetic limitations of traditional peptide-based cancer vaccines hamper effective cross-presentation and codelivery of antigens (Ag) and adjuvants, which are crucial for inducing robust antitumor CD8+ T-cell responses. In this study, we report the development of a versatile strategy that simultaneously addresses the different pharmacokinetic challenges of soluble subunit vaccines composed of Ags and cytosine-guanosine oligodeoxynucleotide (CpG) to modulate vaccine efficacy via translating an engineered chimeric peptide, eTAT, as an intramolecular adjuvant. Linking Ags to eTAT enhanced cytosolic delivery of the Ags. This, in turn, led to improved activation and lymph node–trafficking of Ag-presenting cells and Ag cross-presentation, thus promoting Ag-specific T-cell immune responses. Simple mixing of eTAT-linked Ags and CpG significantly enhanced codelivery of Ags and CpG to the Ag-presenting cells, and this substantially augmented the adjuvant effect of CpG, maximized vaccine immunogenicity, and elicited robust and durable CD8+ T-cell responses. Vaccination with this formulation altered the tumor microenvironment and exhibited potent antitumor effects, with generally further enhanced therapeutic efficacy when used in combination with anti-PD1. Altogether, the engineered chimeric peptide–based orchestrated codelivery of Ag and adjuvant may serve as a promising but simple strategy to improve the efficacy of peptide-based cancer vaccines.
Supplementary Table 1 from Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei
Authors: Villagomez Fabian R. , Lang Julie , Rosario Fredrick J. , Nunez-Avellaneda Daniel , Webb Patricia , Neville Margaret , Woodruff Elizabeth R. , Bitler Benjamin G.
Published: July 2024

BioID Data - Claudin-4 proximal proteins
Supplementary Figure 1 from Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei
Authors: Villagomez Fabian R. , Lang Julie , Rosario Fredrick J. , Nunez-Avellaneda Daniel , Webb Patricia , Neville Margaret , Woodruff Elizabeth R. , Bitler Benjamin G.
Published: July 2024

Confirmation of claudin-4 expression and modulation of the autophagy pathway
Movie 1 from Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei
Authors: Villagomez Fabian R. , Lang Julie , Rosario Fredrick J. , Nunez-Avellaneda Daniel , Webb Patricia , Neville Margaret , Woodruff Elizabeth R. , Bitler Benjamin G.
Published: July 2024

Movie 1 - Hoechst
Creative traces of Los otros hombres en Eva
Authors: Paoletta Anabel Edith , Rosso Martin Miguel
Published: July 2024

This article shares the methodological guidelines carried out by the actors/researchers of the IPROCAE research group (Investigation of Creative Processes in performing Arts) belonging to the Facultad de Arte of the UNCPBA, and its main objetive is to study their  own performing practice simultaneously with their realization in the work Los otros hombres en Eva.
The análisis of the creative process is developed base don the study of the genesis, on the figure of Eva Duarte de Peron and the different artistic approaches related to her mummification; examining the relationship between Theater and politics, in the form of militant theater of the 70s in Argentina; and reflexionating about  the role of chance, or the existing random processes in the production of the contemporary Theater field, where it is used as a creative procedure and scenic construction tool.
Love in uppercase, brazil in lowercase: the love letters written by Ana Cristina Cesar during the dictatorship in Brazil (1964–1985)
Authors: Voltan Raynara Isis Barbosa
Published: July 2024

Amor mais que maiúsculo (2022) reúne as cartas da jovem Ana Cristina Cesar, escritas de 1969 a 1971, ao namorado Luiz Augusto Ramalho. Através dessas cartas é possível inferir certas perspectivas da biografia de Ana C. Cesar, ao mesmo tempo que se pode observar os elementos artificiosos presentes em sua correspondência, tornando indissociáveis vida e obra. Assim, são temas das cartas, além do amor entre os jovens que move toda a escrita epistolar da autora, assuntos como, por exemplo: a arte, a música, seu processo artístico e de pesquisa literária/acadêmica, as suas amizades e processos de leituras, tanto sobre literatura como de história e política. O interesse deste trabalho pauta-se em abordar a relação amorosa entre Ana e Augusto, lançando um olhar para como essa relação é fundida com os problemas políticos do Brasil naquele momento. Propõe-se, portanto, por meio das múltiplas formas de escrita epistolar de Ana Cristina Cesar, analisar como esses dois temas são contrapostos e, ao mesmo tempo, homólogos.
One new species and a new record of saprobic fungi from Ananas comosus in northern Thailand
Authors: SHAH SUJIT , FARIAS ANTONIO ROBERTO GOMES DE
Published: July 2024

Pineapple is one of the major crops in northern Thailand. Like all the other plants, it has associated with it, a wide range of fungi, which may be saprobic, pathogenic, or endophytic. This study investigated fungi associated with pineapple in Chiang Rai Province, northern Thailand. Based on morphology and multilocus phylogeny of the ITS and LSU sequence data, Anthracocystis ananatum is described as a new species with its detailed asexual morph. Compared to other Anthracocystis species, A. ananatum has a distinctive morphotype that includes septate hyphae, conidigenous cells, and conidiophores. In addition, Spegazzinia tessarthra is reported for the first time as a new host and geographic record. The complete descriptions, photo-micrographs, and phylogenies of the new species Anthracocystis ananatum and a new host and geographic record S. tessarthra are provided and discussed.
Ocean Complexity Shapes Sea Surface Temperature Variability in a CESM2 Coupled Model Hierarchy
Authors: Larson Sarah M. , McMonigal Kay , Okumura Yuko , Amaya Dillon , Capotondi Antonietta , Bellomo Katinka , Simpson Isla R. , Clement Amy C.
Published: July 2024

To improve understanding of ocean processes impacting monthly sea surface temperature (SST) variability, we analyze a Community Earth System Model, version 2, hierarchy in which models vary only in their degree of ocean complexity. The most realistic ocean is a dynamical ocean model, as part of a fully coupled model (FCM). The next most realistic ocean, from a mechanically decoupled model (MDM), is like the FCM but excludes anomalous wind stress–driven ocean variability. The simplest ocean is a slab ocean model (SOM). Inclusion of a buoyancy coupled dynamic ocean as in the MDM, which includes temperature advection and vertical mixing absent in the SOM, leads to dampening of SST variance everywhere and reduced persistence of SST anomalies in the high latitudes and equatorial Pacific compared to the SOM. Inclusion of anomalous wind stress–driven ocean dynamics as in the FCM leads to higher SST variance and longer persistence time scales in most regions compared to the MDM. The net role of the dynamic ocean, as an overall dampener or amplifier of anomalous SST variance and persistence, is regionally dependent. Notably, we find that efforts to reduce the complexity of the ocean models in the SOM and MDM configurations result in changes in the magnitude of the thermodynamic forcing of SST variability compared to the FCM. These changes, in part, stem from differences in the seasonally varying mixed layer depth and should be considered when attempting to quantify the relative contribution of certain ocean mechanisms to differences in SST variability between the models.
No Evidence of Winter Warming in Eurasia Following Large, Low-Latitude Volcanic Eruptions during the Last Millennium
Authors: Tejedor Ernesto , Polvani Lorenzo M. , Steiger Nathan J. , Vuille Mathias , Smerdon Jason E.
Published: July 2024

We critically reexamine the question of whether volcanic eruptions cause surface warming over Eurasia in winter, in the light of recent modeling studies that have suggested internal variability may overwhelm any forced volcanic response, even for the very largest eruptions during the Common Era. Focusing on the last millennium, we combine model output, instrumental observations, tree-ring records, and ice cores to build a new temperature reconstruction that specifically targets the boreal winter season. We focus on 20 eruptions over the last millennium with volcanic stratospheric sulfur injections (VSSIs) larger than the 1991 Pinatubo eruption. We find that only 7 of these 20 large events are followed by warm surface temperature anomalies over Eurasia in the first posteruption winter. Examining the 13 events that show cold posteruption anomalies, we find no correlation between the amplitude of winter cooling and VSSI mass. We also find no evidence that the North Atlantic Oscillation is correlated with VSSI in winter, a key element of the proposed mechanism through which large, low-latitude eruptions might cause winter warming over Eurasia. Furthermore, by inspecting individual eruptions rather than combining events into a superposed epoch analysis, we are able to reconcile our findings with those of previous studies. Analysis of two additional paleoclimatic datasets corroborates the lack of posteruption Eurasian winter warming. Our findings, covering the entire last millennium, confirm the findings of most recent modeling studies and offer important new evidence that large, low-latitude eruptions are not, in general, followed by significant surface wintertime warming over Eurasia.
Mapping Lightning Risk in Mexico: Integrating Natural Hazard and Social Vulnerability
Authors: Jaramillo Alejandro , Dominguez Christian
Published: July 2024

Lightning around the world poses a significant threat to life, infrastructure, and economic sectors. This study evaluates lightning risk at the municipal level in Mexico, recognizing the interplay of hazard and vulnerability in risk estimation. Despite declining lightning-related fatalities, possibly attributed to demographic shifts and improved urban infrastructure, persistent social vulnerability exists, particularly among rural populations engaged in labor-intensive agriculture with lower education levels. We estimate a risk map for lightning-related fatality risk in Mexico, where we identify high-risk regions along the Sierra Madre Occidental, the Pacific coast, and central and southeastern Mexico, marked by elevated lightning days and social vulnerability. The risk map integrates hazard and social vulnerability, capturing the distribution of fatality incidents, and it reveals that 82.1% of incidents occurred in municipalities categorized as “high” or “very high” risk. This result emphasizes the need to consider both physical hazard and social vulnerability for a comprehensive assessment of lightning risk. This study contributes to understanding lightning risk in Mexico, providing crucial insights at the municipality level for informing policymaking and targeting risk mitigation strategies. By highlighting the interrelation of hazard and social vulnerability, this research aligns with broader goals of enhancing local resilience and safety in the face of natural hazards, highlighting the ongoing need for disaster risk reduction efforts.

Significance Statement

This study provides a comprehensive evaluation of the risk of death by lightning at the municipality level in Mexico, considering the intricate interplay between hazard and social vulnerability. By analyzing both the physical hazard of lightning and the social vulnerability of exposed populations, the study provides a map estimating the risk level for each municipality. The risk map, capturing the interrelation of hazard and vulnerability, provides a powerful tool for policymakers and emergency responders. With 82.1% of lightning fatalities concentrated in municipalities with “high” and “very high” risk, this work underscores the need for comprehensive risk assessment strategies. This research contributes knowledge for informed decision-making, targeted interventions, and the ongoing pursuit of enhancing community resilience to lightning-related hazards.
Nanosheet integration of induced tunnel field-effect transistor with lower cost and lower power
Authors: Lin Jyi-Tsong , Kuo Chia-Yo
Published: July 2024

Nanosheet transistors are poised to become the preferred choice for the next generation of smaller-sized devices in the future. To address the future demand for high-performance and low-power computing applications, this study proposes a nanosheet structure with a vertically stacked design, featuring a high ION/IOFF ratio. This Nanosheet design is combined with an induced tunnel field-effect transistor. By utilizing SiGe with a carrier mobility three times that of Si and employing a line tunneling mechanism, the research successfully achieves superior Band to Band characteristics, resulting in improved switching behavior and a lower Subthreshold Swing (SS). Comparative studies were conducted on three TFET types: Nanosheet PIN TFET, Nanosheet Schottky iTFET, and Fin iTFET. Results show that the Nanosheet PIN TFET has a higher ION/IOFF ratio but poorer SSavg values at 47.63 mV/dec compared to the others. However, with a SiGe Body thickness of 3 nm, both Nanosheet iTFET and Fin iTFET exhibit higher ION/IOFF ratios and superior SSavg values at 17.64 mV/dec. These findings suggest the potential of Nanosheet iTFET and Fin iTFET for low-power, lower thermal budgets, and fast-switching applications.