bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Selectivity and Timing Skills of Fund Managers
Authors: Agarwal Ashima , Bansal Sanjeev , Dhillon Lakhwinder K. ,   Amity Business School, Amity University, NOIDA, Uttar Pradesh, India.,   Amity Business School, Amity University, NOIDA, Uttar Pradesh, India.,   Amity Business School, Amity University, NOIDA, Uttar Pradesh, India.
Published: May 2020

There have been massive research works done on the concept of market timing and selectivity skills that are applied by the fund managers to optimize the returns to the fundholders/investors/clientele. The fact that still remains unidentified/studied is the factor(s) that are influential enough for the maximization of returns. There is a general perception that investors will only look upon the returns but the very factor that may influence that return is yet to be analyzed. This study focuses on gaining an insight into whether there is any correlation that exists between the fund manager’s selection or/and market timing abilities that, in turn, can be useful to the investors also in finding out which fund and fund manager to be trusted for investment.
An Assessment of the Influence of Working Environment on Service Delivery in the Public Health Sector in Nyeri County, Kenya
Authors: Theuri Mary W , Macharia Stephen , Kamau Alice ,   Department of Human Resource Development, Karatina University, P.O. Box 1957-010101, Karatina, Kenya.,   Department of Human Resource Development, Karatina University, P.O. Box 1957-010101, Karatina, Kenya.,   Department of Human Resource Development, Karatina University, P.O. Box 1957-010101, Karatina, Kenya.
Published: May 2020

Globally, the health sector is an area that any government must focus on since health is a right of every human being. Kenya particularly initiated the idea of devolution and the Big Four Agenda to ensure service delivery to citizens was achieved. Nevertheless, the situation in the public health sector has been encountering challenges due to dissatisfaction of personnel culminating in strikes. The objective of this study was to explore the effect of the working environment on service delivery in the health sector in Nyeri County, Kenya. The study was guided by the person–environment fit theory. The descriptive cross-sectional research design was used. The target population was derived from public hospitals in Nyeri County. Proportionate stratified random sampling was utilized, where 141 respondents were targeted, comprising doctors, clinical officers, and nurses. Data was collected using a closedended questionnaire. A pilot study was conducted at Mukurwe-ini Hospital to enhance the validity and reliability of the data-collection instrument. A Cronbach alpha coefficient of 0.7 was used to ascertain the reliability of the instrument. Data was analyzed using descriptive and inferential statistics from the 78.7% respondents. The findings established that the working environment had positive and significant effects on service delivery (β1 = 0.476, p-value = 0.000) at the 5% level of significance, hence rejecting the null hypothesis. The study further established that the public health sector in Kenya should address the drug shortage, medical staff working hours, and machine maintenance as they would adversely affect quality of service delivery. The study recommends that the public health sector should provide health workers a conducive working environment and all necessary tools and equipment to enable them to discharge their duties effectively with a view to enhance service delivery to patients. Future research should focus on the importance of on–the-job training for effective service delivery in the public health sector.
How to Evaluate Collaboration within Research and Innovation
Authors: Svensson Ann
Published: May 2020

To improve and strengthen regional development is often subject of political decisions. This is the situation within the European Union, to increase innovation in SMEs. SMEs need access to knowledge, competence and collaboration, in order to increase their opportunities to develop competitiveness in products higher up in the value chain. The increasing rate of change in society also creates needs of decreasing the time from knowledge development to ready products to the market. Ongoing evaluation is prevalent in many research and development projects today in order to follow up the intended results. The ongoing evaluation could contribute to increase the efficiency and effectiveness of a specific innovation project by highlight areas of improvement and needs of development.
The sequence of Remicourt (Hesbaye, Belgium): new insights on the pedo- and chronostratigraphy of the Rocourt soil
Authors: HAESAERTS Paul , MESTDAGH Hans , BOSQUET Dominique
Published: May 2020

For more than 40 years the Rocourt Soil has stood out as an important pedo-stratigraphic marker in Belgium and north-western Europe. Since the seventies the complexity of this Soil was well illustrated, though its pedological and stratigraphic evolution remained doubtful. Macro-, meso- and micromorphological data gathered along long variable sections in Remicourt finally provided the 'missing link' between the Hesbaye sections and the Haine Basin. Soil characteristics allowed to match the Rocourt Soil with three major soil forming processes belonging to the Eemian and the first half of Saint Germain I (18O-stages 5e and 5c). The overlying humiferous sediments and soils, which also incorporate the Rocourt Tephra, are linked with the second half of Saint-Germain I (18O-stage 5c). The loess, stratified sediments and soil covering the humiferous layer are the equivalent of E.B.I, E.B.2 and Malplaquet Soil in Harmignies and belong to Melisey II and Saint Germain II (18O-stage 5b and 5a).
Téphrostratigraphie du Quaternaire en Belgique [Quaternary tephrostratigraphy in Belgium]
Authors: JUVIGNE Etienne
Published: May 2020

The main characteristics of Quaternary volcanic ash-falls found in various terrains of Belgium are put together. An exhaustive list of papers dealing with Quaternary tephrostratigraphy in Belgium is presented in an appendix.
Avaliando o Ambiente de Inovação da Região do Triângulo da Pesquisa
Authors: Goncalves do Amaral Marcelo , Faria Adriana Ferreira de , Schocair Marília Medeiros
Published: May 2020

O artigo estuda a Região do Triângulo da Pesquisa (RTR), uma área de desenvolvimento econômico no estado da Carolina do Norte, EUA. O RTR compreende dois parques tecnológicos principais: o Research Triangle Park e o Centennial Campus da Universidade Estadual da Carolina do Norte. Foi aplicado o Modelo Amaral para Gestão de Ambientes de Inovação (AMIEM) aos parques da RTR e foram discutidos aspectos do desenvolvimento regional sob o prisma da gestão da inovação, além da adequação do modelo como uma ferramenta para avaliar ambientes complexos. O método de pesquisa é descritivo e exploratório. A pesquisa de campo, realizada durante os anos de 2016 e 2017, envolveu revisão de literatura, coleta de documentos e entrevistas semiestruturadas. O AMIEM é um modelo quali-quanti com onze fatores para medir o nível de maturidade das relações do tipo Triple Helix entre atores da academia (produtores de conhecimento), do setor produtivo de bens e serviços (produtores e usuários de conhecimento) e do governo (regulador social e econômico). Os parques da RTR possuem um alto nível de maturidade. Várias iniciativas bem-sucedidas e sobrepostas foram encontradas nos últimos sessenta anos, explicando o desenvolvimento regional.
O modelo da Quíntupla Hélice e o futuro da mobilidade: O papel dos veículos autônomos em um país em desenvolvimento
Authors: Gandia Rodrigo Marçal , Veroneze Ricardo Braga , Antonialli Fabio , Cavazza Bruna Habib , Sugano Joel Yutaka , Nicolaï Isabelle
Published: May 2020

This descriptive paper of qualitative approach aimed at understanding whether the Quintuple Helix Model (QHM) can positively foster advancements on urban mobility from AVs’ insertion in the society, as well as discuss the dynamic of the QHM in the Brazilian context. Synergy among agents proposed by the model is essential for minimizing the impacts on innovation development. It is necessary to understand AVs’ development not only as a technological innovation that will bring comfort to society, but rather to realize that this radical innovation can transform the future of urban mobility worldwide. In a Brazilian context, we observed that the country needs to improve in many aspects in order to carry on the future of urban mobility. Brazilians tend to be early technology adopters and the country has good mobile networks, but it will need to improve on regulations, local innovation and road quality to take advantage of AVs (KPMG, 2018). Finally, QHM can corroborate to such needed improvement and, our proposed theoretical framework could explain how this dynamic works.
Particularities in financing tools: A case study of an Agency for Science, Technology and Innovation of Rio de Janeiro State, Brazil
Authors: Almeida Daniel Pereira de , Renault Thiago Borges , Angelkorte Gerd Brantes , Fonseca Marcus Vinicius de Araujo , Yates Sérgio
Published: May 2020

Abstract: This work aims to analyze the objectives and interactions of innovation financing tools from a point of view of a technology, research and innovation foundation. It brings as subject the case of the Technology, Research and Innovation Foundation of the State of Rio de Janeiro (FAPERJ), and its incorporation of a Technology Board. Working side by side with a Scientific Board, it faces the challenge of interact, finance, and boost innovation, whereas the Foundation carries more than 40 years of basic research funding (1980 until 2019) the financing of innovation activities was incorporated in 2002. With the R&D activities in Brazil centered on public University, Research Institutes and only a small presence in companies (only 5% of the innovative companies perform R&D), FAPERJ’s faces the challenge of create financing tools that improves the interaction between these actors. The sample analyzed in this study relates the eligibility criteria used in the FAPERJ’s Technological Development Support (ADT) with similar and inspiring program, the United States of America Small Business Innovation Research (SBIR). As result, we have found the lack of incentives for interaction between universities and business sector, showing that only a small part of the projects financed by FAPERJ can reach the commercialization.
Assembling reads improves taxonomic classification of species
Authors: Tran Quang , Phan Vinhthuy
Published: May 2020

Background: Most current metagenomic classifiers and profilers employ short reads to classify, bin and profile microbial genomes that are present in metagenomic samples. Many of these methods adopt techniques that aim to identify unique genomic regions of genomes so as to differentiate them. Because of this, short-read lengths might be suboptimal. Longer read lengths might improve the performance of classification and profiling. However, longer reads produced by current technology tend to have a higher rate of sequencing errors, compared to short reads. It is not clear if the trade-off between longer length versus higher sequencing errors will increase or decrease classification and profiling performance.Results: We compared performance of popular metagenomic classifiers on short reads and longer reads, which are assembled from the same short reads. When using a number of popular assemblers to assemble long reads from the short reads, we discovered that most classifiers made fewer predictions with longer reads and that they achieved higher classification performance on synthetic metagenomic data. Specifically, across most classifiers, we observed a significant increase in precision, while recall remained the same, resulting in higher overall classification performance. On real metagenomic data, we observed a similar trend that classifiers made fewer predictions. This suggested that they might have the same performance characteristics of having higher precision while maintaining the same recall with longer reads.Conclusions: This finding has two main implications. First, it suggests that classifying species in metagenomic environments can be achieved with higher overall performance simply by assembling short reads. This suggested that they might have the same performance characteristics of having higher precision while maintaining the same recall as shorter reads. Second, this finding suggests that it might be a good idea to consider utilizing long-read technologies in species classification for metagenomic applications. Current long-read technologies tend to have higher sequencing errors and are more expensive compared to short-read technologies. The trade-offs between the pros and cons should be investigated.
Parvimonas Micra Promotes Intestinal Tumorigenesis in Conventional Apcmin/+ Mice and in Germ-Free Mice
Authors: Zhao Liuyang , Zhou Yunfei , Zhao Risheng , Coker Olabisi Oluwabukola Oluwabukola , ZHANG Xiang , Chu Eagle SH , Wei Hong , Wu William KK , Wong Sunny Hei , Sung Joseph JY , To Ka Fai , Yu Jun
Published: May 2020

Background:Large-scale meta-analysis of fecal shotgun metagenomic sequences revealed high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role of P. micra in colon tumorigenesis.Results: P. micra was significantly enriched in 128 stool samplesfrom CRC patients compared with 181 samples from healthy controls(p<0.0001) and in 52 pairedtissue biopsies from CRC patientsthan 61 samples from healthy individuals (p<0.05). P. micra strain 512 was isolated from the feces of a CRC patient.Colon cell lines exposed to P. micra- conditioned medium significantly increased cell proliferation.Apcmin/+ mice gavaged with P. micra exhibited significantly higher tumor burden and load (both p<0.01). Consistently, cell proliferation was significantly higher in the colon tissues of germ-free mice gavaged with P. micraevidenced by increased Ki-67-positive cells and PCNA protein expression. Th2 and Th17 cells were markedly increased, while Th1 cells were reduced in the lamina propria of the colon tissues of mice gavaged with P. micra (all p<0.01). Moreover, P. micra colonization in germ-free mice was associated with increased expression of pro-inflammatory cytokines including Tnf-α, Il17a, Il6 and Cxcr1.Conclusions: P. micra promoted intestinal carcinogenesis in Apcmin/+ mice and increased cell proliferation in germ-free mice. The tumor-promoting effect of P. micra was associated with altered immune responses and enhanced inflammation in the gut.
Estimation of fuel potential of faecal sludge in a water scarce city, a case study of Jaipur Urban, India
Authors: Sharma Niharika , Gupta Sagar , Vyas Anil Dutt
Published: May 2020

Non-sewer sanitation systems are widely implemented for treatment and management of faecal sludge (FS) and septage in developing nations. India became an open defecation free (ODF) country in 2019, with more than 90 million toilets at rural and urban level constructed to achieve this ODF status. Government of India also initiated a faecal sludge and septage management (FSSM) policy in 2017. This paper highlights the policy vision for the state of Rajasthan and predicts options for a safely managed sanitation system through exploring the fuel potential of faecal sludge generated in the city. The intended study is an attempt to valorize faecal sludge into a marketable product through determining the heat capacity of dried faecal sludge from different sources such as pit toilets, septic tanks etc. In the present work in urban Jaipur, which is already a water scarce city, various onsite sanitation systems were targeted to collect FS samples from different locations. It was observed that the FS generated has a high heating value of 13.96 MJ/kg, with total solids ranges from 7 to 9%. For a pragmatic resource recovery option, the experimental data observed is validated with a literature review.
Biochemical Markers in the Prediction of Contrast-induced Acute Kidney Injury
Authors: Zdziechowska Magdalena , Gluba-Brzózka Anna , Franczyk Beata , Rysz Jacek
Published: May 2020

For many years clinicians have been searching for “kidney troponin”- a simple diagnostic
tool to assess the risk of acute kidney injury (AKI). Recently, the rise in the variety of contrast-related
procedures (contrast computed tomography (CT), percutaneous coronary intervention (PCI) and angiography)
has resulted in the increased number of contrast-induced acute kidney injuries (CI-AKI). CIAKI
remains an important cause of overall mortality, prolonged hospitalisation and it increases the total
costs of therapy. The consequences of kidney dysfunction affect the quality of life and they may
lead to disability as well. Despite extensive worldwide research, there are no sensitive and reliable
methods of CI-AKI prediction. Kidney Injury Molecule 1 (KIM-1) and Neutrophil Gelatinase
Lipocalin (NGAL) have been considered as kidney-specific molecules. High concentrations of these
substances before the implementation of contrast-related procedures have been suggested to enable the
estimation of kidney vulnerability to CI-AKI and they seem to have the predictive potential for cardiovascular
events and overall mortality. According to other authors, routine determination of known inflammation
factors (e.g., CRP, WBC, and neutrophil count) may be helpful in the prediction of CIAKI.
However, the results of clinical trials provide contrasting results. The pathomechanism of contrast-
induced nephropathy remains unclear. Due to its prevalence, the evaluation of the risk of acute
kidney injury remains a serious problem to be solved. This paper reviews pathophysiology and suggested
optimal markers facilitating the prediction of contrast-induced acute kidney injury.
Plant-microbe Interactions for Sustainable Agriculture in the Postgenomic Era
Authors: Agrahari Raj Kishan , Singh Prashantee , Koyama Hiroyuki , Panda Sanjib Kumar
Published: May 2020

Plant-microbe interactions are both symbiotic and antagonistic, and the knowledge of both these interactions is equally important for the progress of agricultural practice and produce. This review gives an insight into the recent advances that have been made in the plant-microbe interaction study in the post-genomic era and the application of those for enhancing agricultural production. Adoption of next-generation sequencing (NGS) and marker assisted selection of resistant genes in plants, equipped with cloning and recombination techniques, has progressed the techniques for the development of resistant plant varieties by leaps and bounds. Genome-wide association studies (GWAS) of both plants and microbes have made the selection of desirable traits in plants and manipulation of the genomes of both plants and microbes effortless and less time-consuming. Stress tolerance in plants has been shown to be accentuated by association of certain microorganisms with the plant, the study and application of the same have helped develop stress-resistant varieties of crops. Beneficial microbes associated with plants are being extensively used for the development of microbial consortia that can be applied directly to the plants or the soil. Next-generation sequencing approaches have made it possible to identify the function of microbes associated in the plant microbiome that are both culturable and non-culturable, thus opening up new doors and possibilities for the use of these huge resources of microbes that can have a potential impact on agriculture.
Effect of Nectaroscordum koelzi Methanolic Extract on Acute and Chronic Inflammation in Male Mice
Authors: Khaksarian Mojtaba , Mahmoudvand Hormoz , Alipour Maryam , Naizi Massumeh , Hasanvand Karam Hossein , Nadri Sedighe
Published: May 2020

Introduction:

The present study deals with the effect of Nectaroscordum koelzi fruit
extract on acute and chronic inflammation.

Methods:

A total of 84 NMRI mice were used in this study. The effect of the extract on acute inflammation
was analyzed by increasing vascular permeability via acetic acid and xylene induced
ear edema among mice. The extract was evaluated in terms of effects on chronic inflammation by
means of the cotton pellet test among mice. For the assessment of inflammation degree, the mice
paw edema volume was measured by the plethysmometric test.

Results:

The findings showed that the extract was effective on acute inflammation induced by
acetic acid in mice. In the xylene ear edema, N. koelzi extract indicated a significant activity in
mice. In the cotton pellet method, the methanol extract produced a significant reduction in comparison
with the control and dexamethasone. Mice paw edema volume decreased with the extract.

Conclusion:

In general, the data from the experiments indicated that the methanol extract of N.
koelzi has an anti-inflammatory effect on acute and chronic inflammation. However, the exact
contributing mechanisms have not been investigated for the pharmacological effects.
The Intersection of Maternal Morbidity and Mortality and Intimate Partner Violence in the United States
Authors: Noursi Samia , Clayton Janine Austin , Campbell Jacquelyn , Sharps Phyllis
Published: May 2020

Background:

In the United States, rates of maternal morbidity and mortality (MMM) are
high compared with other high-income countries and are characterized by significant racial/ethnic
disparities. Typically, research on MMM focuses on obstetrical problems. Less research examines
the role of intimate partner violence (IPV). Maternal health, IPV, and their intersection are linked
with the impacts of social determinants of health.

Objective:

We sought to understand the intersection of MMM and IPV in the United States, particularly
data issues that hinder research in this area and the resulting knowledge gaps.

Methods:

We identified major articles of interest regarding maternal morbidity and mortality and
IPV in the United States and drafted a mini review based on relevant information.

Results:

Despite the prevalence of IPV during pregnancy, the intersection of maternal health and
IPV has not been widely reviewed or discussed.

Conclusion:

There are a number of limitations in surveillance activities and data collection that
underestimate the impact of IPV on MMM. Importantly, women who die by homicide or suicide—
which in many cases is linked with IPV—are not counted as pregnancy-related deaths in the United
States under the current definition. Establishing separate panels of local experts in maternal health
or maternal mortality review committees (MMRCs) that are dedicated to examining violent deaths
and use of the Maternal Mortality Review Information Application system would likely improve
data accuracy of pregnancy-associated deaths. Based on the literature reviewed and limitations of
current data, there are significant knowledge gaps on the effects of IPV and maternal health.
The Apoptosis Mechanism of Epirubicin Combined with BCG on Human Bladder Cancer Cells
Authors: Luo Yang , Fu Xiaoyi , Han Bin , Zhang Fafu , Yuan Lihong , Men Hongsheng , Zhang Shulin , Tian Sujuan , Dong Bin , Meng Minjie
Published: May 2020

Aims:

The purpose of our study was to explore the combination effect of epirubicin and Bacillus
Calmette Guerin (BCG) and its mechanism.

Background:

Bladder cancer is a threat to human health worldwide. Commonly used chemotherapy drugs and
biotherapy have significant therapeutic effects on bladder cancer, but the mechanism and combined effects are
still unclear.

Objective:

To evaluate the anti-cancer effect of epirubicin combined with BCG on human bladder cancer cells,
our studies were carried out.

Methods:

The viability of human bladder cancer cells with epirubicin and/or BCG treatments was
examined by Cell Counting Kit-8 (CCK-8) assay. Apoptosis and cell cycle phase were
determined by flow cytometry analysis. Pre-apoptosis factors of caspase-3, p53, B-cell
lymphoma 2 associated X protein (Bax) and anti-apoptosis factor of B-cell lymphoma 2 (Bcl2) were detected by western blot.

Results:

The viability of human bladder cancer with epirubicin or BCG treatment was decreased and the viability
with epirubicin combined with BCG treatment was decreased more, which were determined by CCK-8
assay. Both epirubicin and BCG increased the apoptosis rate of human bladder cancer and arrested more cells
into G0/G1 phase, which were tested by flow cytometry. The expression of caspase-3, p53 and Bax was increased
and the expression of Bcl-2 was decreased with epirubicin treatment on human bladder cells, which
were analyzed by western blot. The expression of caspase-3 and p53 was increased with BCG treatment, which
was examined by western blot.

Conclusion:

Epirubicin induced apoptosis in human bladder cancer cells by up-regulating the expression of proapoptotic
factors (caspase-3, p53 and Bax) and down-regulating the expression of anti-apoptotic factor (Bcl-2).
BCG promoted apoptosis of human bladder cancer cells by up-regulating the expression of caspase-3 and p53.
BCG plays a potential role at the time of the combination of epirubicin and BCG on bladder cancer cells in early
stage. Both epirubicin and BCG affected cell cycle distribution via arresting more bladder cancer cells at G0/G1
phase, which ultimately led bladder cancer proliferation in vitro and promoted apoptosis.
MicroRNA-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells
Authors: Ragheb Mohamed A. , Soliman Marwa H. , Elzayat Emad M. , Mohamed Mervat S. , El-Ekiaby Nada , Abdelaziz Ahmed I. , Abdel-Wahab Abdel-Hady A.
Published: May 2020

Background:

Doxorubicin (DOX) is the most common drugs used in cancer therapy, including
Hepatocellular Carcinoma (HCC). Drug resistance, is one of chemotherapy’s significant
problems. Emerging studies have shown that microRNAs (miRNAs) could participate in
regulating this mechanism. Nevertheless, the impact of miRNAs on HCC chemoresistance is still
enigmatic.

Objective:

Investigating the role of miR-520c-3p in enhancement of anti-tumor effect of DOX
against HepG2 cells.

Methods:

Expression profile for liver related miRNAs (384 miRNAs) has been analyzed on
HepG2 cells treated with DOX using qRT-PCR. miR-520c-3p, the most deregulated miRNA,
was selected for combination treatment with DOX. Expression level for LEF1, CDK2, CDH1,
VIM, Mcl-1 and TP53 was evaluated in miR-520c-3p transfected cells. Cell viability, colony
formation, wound healing as well as apoptosis assays have been demonstrated. Furthermore,
Mcl-1 protein level was measured using western blot technique.

Results:

The present data indicated that miR-520c-3p overexpression could render HepG2 cells
chemo-sensitive to DOX through enhancing its suppressive effects on proliferation, migration,
and induction of apoptosis. The suppressive effect of miR-520c-3p involved altering the
expression levels of some key regulators of cell cycle, proliferation, migration and apoptosis
including LEF1, CDK2, CDH1, VIM, Mcl-1 and TP53. Interestingly, Mcl-1 was found to be one
of the potential targets of miR-520c-3p, and its protein expression level was down-regulated
upon miR-520c-3p overexpression.

Conclusion:

Our data referred to the tumor suppressor function of miR-520c-3p that could
modulate chemosensitivity of HepG2 cells toward DOX treatment, providing a promising
therapeutic strategy in HCC.
The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information
Authors: Dereli Fatma T.G. , Ilhan Mert , Akkol Esra K.
Published: May 2020

Background:

The fruits with the seeds of Dracunculus vulgaris Schott. (Araceae) are used against
inflammatory diseases in Turkey.

Objective:

Present study was designed to justify this folkloric usage type of the plant. Therefore, the aim of this study
is to investigate the anti-inflammatory activity of D. vulgaris.

Methods:

Petroleum ether, ethyl acetate and methanol extracts were prepared from the fruits, successively.
Carrageenan-, serotonin-, and prostaglandin E2-induced hind paw edema; acetic acid–induced capillary permeability
and 12-O-tetradecanoyl-phorbol-13-acetate–induced mouse ear edema models were used to assess the antiinflammatory activity of the extracts. The analgesic activity was experienced by using p-benzoquinone-induced
abdominal constriction test.

Results:

The petroleum ether extract displayed the highest activities in all of the used test models compared with the
control group. Therefore, the constituents of this extract were determined by using gas chromatography–mass
spectroscopy (GC–MS). Linoleic acid was found to be major constituent of the petroleum ether extract of D.
vulgaris.

Conclusion:

This study has provided some justification for the folkloric use of the plant.
Design of Quantum Cost and Delay Optimized Code Converter Using New Reversible Quantum Circuit Block (QCB)
Authors: Maity Heranmoy , Banerjee Sudipta , Mistry Raton , Kundu Parna , Ojha Kriti , Manwani Priya , Sen Barnali , Verma Ishika , Biswas Arindam , Pal Anita , Bhattacharjee Anup Kumar
Published: May 2020

Background:

In this article, we have proposed a new reversible quantum circuit block along
with the quantum cost (QC), constant input (CI), garbage output (GO) and delay optimized
code converterusing quantum circuit block.

Method:

Initially, new quantum circuit block has been designed and later reversible code
converter circuits have been implemented using it. The proposed new quantum blockused
to design 2’s complement code converter (2SCCC), cost efficient BCD to Excess-3 code
converter (BECC) and can also be used to implement different logic functions. The QC of
proposed quantum circuit block is 8. The QC and delay of the proposed 2SCCC is 8 and 1
respectively. Similarly, the QC and delay of the proposed BECC is 11 and 2 respectively.
The proposed cost efficient BECC is designed using two NOT gate, one Feynman gate and
one new quantum circuit block with QC is 11.

Results:

The improvement of QC for 2SCCC and BECC are 27.27 % and 21.43%
respectively. The improvement of delay for 2SCCC and BECC are 66.67% and 50%
respectively compared with respect to the latest reported results.

Conclusion:

So the improvement of QC and delay are very high using QCB.
O Projeto gastronômico da Amazônia
Authors: Vieira FLÁVIA do Amaral , Brito Ciro de Souza
Published: May 2020

A gestão do patrimônio histórico-cultural e os direitos humanos são a temática central deste artigo, que analisa o projeto de criação do Polo Gastronômico da Amazônia na cidade de Belém, apresentado pelo Governo do Estado do Pará em 2016. Ante o projeto, é destacada a ampla mobilização da sociedade em reação a irregularidades relacionadas à falta de transparência e acesso a informação, desmobilização de um museu que existia no local e a ausência de consulta prévia, livre e informada aos detentores de conhecimento tradicional atingidos direta e indiretamente pelo empreendimento. São apresentadas reflexões sobre a tutela jurídica do conhecimento tradicional, o direito à consulta prévia e sobre as lutas de resistência na Amazônia. Conclui-se que este projeto nasceu desconectado da compreensão de desenvolvimento da comunidade local, em um cenário em que se evidenciaram mobilizações coletivas de resistência que podem ser capazes de modificar a situação, em prol de compreensões outras de desenvolvimento para a cidade.
A problemática da violência Conjugal em Moçambique
Authors: Leao Cezerilo Fernanda Amelia dos Santos
Published: May 2020

Com o  presente artigo pretende-se fazer um estudo sociológico sobre a violência conjugal entre casais heteronormativo, fenômeno presente em muitos relacionamentos afectivos. Para a operaconalização deste trabalho recorreu se a pesquisa biblográfica, análise documental e entrevistas informais com alguns atores sociais que dia a dia lidam e intervêm nestes casos, para melhor perceber como é que se dá esta violência conjugal, com o fito de sugerir medidas para a sua prevenção, devido as suas nefastas consequências, em especial para a saúde dos envolvidos. A violência representa ou constitui uma grande inquietação para a sociedade O estudo visa igualmente proporcionar uma reflexão a partir de dados teóricos sobre o gênero e desigualdades resultantes do sistema patriarcal, que pode estar relacionado com a prática da violência em relacionamentos conjugais e ao mesmo tempo visa servir de um alerta para a sociedade em geral sobre esta problematica social. Os resultados apontam que a violência do gênero em Moçambique independe do nível de escolaridade da vítima.

Palavras-chave: Gênero.Violência. Resiliência. Relação conjugal.
Educação jurídica e teoria dos sistemas
Authors: Magalhães Frederico
Published: May 2020

A existência de poucas pesquisas a respeito da educação jurídica à luz da teoria dos sistemas constitui campo teórico que pede por maiores investigações, considerando as contribuições sociais que uma pesquisa a partir desse referencial teórico pode trazer, seja na avaliação qualitativa dos cursos de direito, seja na formulação de políticas públicas na área da educação do direito. Diante desse cenário, cumpre perguntar como a educação jurídica pode ser observada à luz da teoria dos sistemas sociais de Niklas Luhmann. Para responder tal pergunta o presente trabalho valeu-se do marco teórico da teoria dos sistemas e do método luhmanniano da comparação funcional, bem como da abordagem qualitativa e da técnica de revisão de literatura para realizar uma pesquisa teórica a respeito da educação jurídica. Como hipótese levantada a partir da discussão, observou-se que a educação jurídica é um programa do sistema educativo que comporta quatro subprogramas (praxista, acadêmico, popular e o concursando), todos eles oriundos dos estímulos que os sistemas parciais da sociedade (direito, ciência, movimentos sociais, política, economia...) trazem para o sistema da educação.
A desigual distribuição do status de criminoso:
Authors: Kobielski Marina Balestrin , Azevedo Rodrigo Ghiringhelli
Published: May 2020

A percepção das dinâmicas de criminalização e estigmatização, pensadas desde a teoria do Labeling Approach, passando pelo estudo dos crimes de colarinho branco, até conceitos propostos na contemporaneidade são o fio condutor deste trabalho. A partir disso, abordar a criminalidade patrimonial, tomando como objeto de estudo os tipos penais de furto e peculato, com o fim de verificar a existência de diferenciação no tratamento dos sujeitos que praticam tais delitos pelo sistema de justiça criminal é o objetivo principal deste artigo.
Violência contra a mulher negra no Brasil
Authors: Garcia Danler
Published: May 2020

Este estudo possui como escopo abordar como a violência contrária às mulheres negras brasileiras possui hostilidades singulares e complexas. As mulheres negras possuem identidades interconectadas por marcadores sociais da diferença para além do gênero, mas, outrossim, pela raça e classe. Nesse sentido, sexismo, misoginia, racismo e classismo, enquanto estruturas congregadas, consubstanciam em desiguais vivências e experiências concernentes à violência, mais árduas e hostis. Por intermédio do campo de estudos da interseccionalidade, precipuamente sua dimensão criminológica, vale dizer, a criminologia interseccional, este estudo, ao investigar os documentos de vitimização brasileiros e estudos teórico-empíricos, alude que as mulheres negras brasileiras padecem de violências múltiplas, a datar de uma violência simbólica que as hipersexualiza e objetifica, e que, ao fim, alveja seu ápice na desmedida violência letal que as aniquila. Assim, a cor da pele das mulheres negras no Brasil aparenta ser mais do que tão somente uma idiossincrasia fenotípica, mas um símbolo de vulnerabilidade e violência.
Pesquisa e escrita acadêmica em direito
Authors: Fonseca Gabriel Ferreira da
Published: May 2020

Este texto guia-se pela seguinte pergunta central: quais as principais recomendações práticas que os pesquisadores do campo do Direito devem seguir para alcançar bons resultados em suas monografias, dissertações e teses? Para chegar a uma resposta para tal questão de caráter prescritivo, recorro às minhas próprias experiências no campo da pesquisa em Direito, notadamente nas áreas da Teoria do Direito e da Sociologia Jurídica, e, principalmente, à literatura produzida em tais áreas e no campo da Metodologia da Pesquisa. Sob a influência do construtivismo sistêmico de autores como Niklas Luhmann, o trabalho analisa diferentes etapas da produção científica (desde a preparação inicial da pesquisa até a revisão final do texto), aliando descrições de inspiração sociológica com recomendações de caráter metodológico.
Movimentos sociais e direito
Authors: Bonfigli Fiammetta , Schwartz Germano
Published: May 2020

O presente artigo visa a recompor e a interpretar os acontecimentos que fizeram do Brasil um teatro de protestos em massa contra o aumento da tarifa dos ônibus urbanos no ano de 2013 Movimento Passe Livre. O ensaio  tem como foco especifico a cidade de Porto Alegre e a ocupação de sua Câmara de Vereadores em julho 2013. O objetivo é o de entender a relação entre a organização política do Bloco de Luta pelo Transporte Publico e seu GT Jurídico durante os oito dias de ocupação. Por meio de nove entrevistas semiestruturadas realizadas exclusivamente com os componentes do GT mencionado, procura-se entender como o Direito é uma ferramenta utilizada pelos movimentos sociais, quais suas dinâmicas relacionais e quais são seus pontos convergentes e divergentes. Nesse sentido, especial atenção é dada ao deferimento da reintegração de posse e a elaboração de dois projetos de lei sobre o transporte público como principais momentos de relação entre a organização coletiva da ocupação e o GT jurídico.
Impact of the Price of Gifts From Patients on Physicians’ Service Quality in Online Consultations: Empirical Study Based on Social Exchange Theory (Preprint)
Authors: Wang Yanan , Wu Hong , Xia Chenxi , Lu Naiji
Published: May 2020

BACKGROUND

Gift giving from patients to physicians, which is prohibited in traditional clinical settings in China, has been found to occur in online health communities. However, there is debate on the validity of online gifts since physicians gain an economic benefit. Moreover, the potential impact of these gifts, particularly with respect to the financial value of the gift, on the online consultation service quality remains unexplored.

OBJECTIVE

The aim of this study was to explore the impact of gift price on the quality of physicians’ online consultation service. Insight into this impact is expected to help resolve existing debate on the appropriateness of the gift-giving practice in online consultations.

METHODS

A dataset of 141 physicians and 4249 physician-patient interactions was collected from the Good Physician Online website, which is the largest online consultation platform in China. Based on social exchange theory, we investigated how gift price affects the quality of physicians’ online consultation service and how this impact changes according to the physician’s service price and number of all gifts received. Manual annotation was used to identify the information support paragraphs and emotional support paragraphs in the answers of physicians. The quality of the information support paragraphs, rather than the complete answer, was used to test the robustness of our model.

RESULTS

Gift price had a positive impact on the quality of physicians’ online consultation service (β=4.941, P<.01). This impact was negatively mediated by both the physician’s service price (β=–9.245, P<.001) and the total number of gifts they received (β=–5.080, P<.001).

CONCLUSIONS

Gift price has a positive impact on physicians’ online behavior, although the impact varies among physicians.
Experiences of a National Web-Based Heart Age Calculator for Cardiovascular Disease Prevention: User Characteristics, Heart Age Results, and Behavior Change Survey (Preprint)
Authors: Bonner Carissa , Raffoul Natalie , Battaglia Tanya , Mitchell Julie Anne , Batcup Carys , Stavreski Bill
Published: May 2020

BACKGROUND

Heart age calculators are used worldwide to engage the public in cardiovascular disease (CVD) prevention. Experimental studies with small samples have found mixed effects of these tools, and previous reports of population samples that used web-based heart age tools have not evaluated psychological and behavioral outcomes.

OBJECTIVE

This study aims to report on national users of the Australian heart age calculator and the follow-up of a sample of users.

METHODS

The heart age calculator was launched in 2019 by the National Heart Foundation of Australia. Heart age results were calculated for all users and recorded for those who signed up for a heart age report and an email follow-up over 10 weeks, after which a survey was conducted. CVD risk factors, heart age results, and psychological and behavioral questions were analyzed using descriptive statistics and chi-square tests. Open responses were thematically coded.

RESULTS

There were 361,044 anonymous users over 5 months, of which 30,279 signed up to receive a heart age report and 1303 completed the survey. There were more women (19,840/30,279, 65.52%), with an average age of 55.67 (SD 11.43) years, and most users knew blood pressure levels (20,279/30,279, 66.97%) but not cholesterol levels (12,267/30,279, 40.51%). The average heart age result was 4.61 (SD 4.71) years older than the current age, including (23,840/30,279, 78.73%) with an older heart age. For the survey, most users recalled their heart age category (892/1303, 68.46%), and many reported lifestyle improvements (diet 821/1303, 63.01% and physical activity 809/1303, 62.09%). People with an older heart age result were more likely to report a doctor visit (538/1055, 51.00%). Participants indicated strong emotional responses to heart age, both positive and negative.

CONCLUSIONS

Most Australian users received an older heart age as per international and UK heart age tools. Heart age reports with follow-up over 10 weeks prompted strong emotional responses, high recall rates, and self-reported lifestyle changes and clinical checks for more than half of the survey respondents. These findings are based on a more engaged user sample than previous research, who were more likely to know blood pressure and cholesterol values. Further research is needed to determine which aspects are most effective in initiating and maintaining lifestyle changes. The results confirm high public interest in heart age tools, but additional support is needed to help users understand the results and take appropriate action.
Deep Learning Methodology for Differentiating Glioma Recurrence From Radiation Necrosis Using Multimodal Magnetic Resonance Imaging: Algorithm Development and Validation (Preprint)
Authors: Gao Yang , Xiao Xiong , Han Bangcheng , Li Guilin , Ning Xiaolin , Wang Defeng , Cai Weidong , Kikinis Ron , Berkovsky Shlomo , Di Ieva Antonio , Zhang Liwei , Ji Nan , Liu Sidong
Published: May 2020

BACKGROUND

The radiological differential diagnosis between tumor recurrence and radiation-induced necrosis (ie, pseudoprogression) is of paramount importance in the management of glioma patients.

OBJECTIVE

This research aims to develop a deep learning methodology for automated differentiation of tumor recurrence from radiation necrosis based on routine magnetic resonance imaging (MRI) scans.

METHODS

In this retrospective study, 146 patients who underwent radiation therapy after glioma resection and presented with suspected recurrent lesions at the follow-up MRI examination were selected for analysis. Routine MRI scans were acquired from each patient, including T1, T2, and gadolinium-contrast-enhanced T1 sequences. Of those cases, 96 (65.8%) were confirmed as glioma recurrence on postsurgical pathological examination, while 50 (34.2%) were diagnosed as necrosis. A light-weighted deep neural network (DNN) (ie, efficient radionecrosis neural network [ERN-Net]) was proposed to learn radiological features of gliomas and necrosis from MRI scans. Sensitivity, specificity, accuracy, and area under the curve (AUC) were used to evaluate performance of the model in both image-wise and subject-wise classifications. Preoperative diagnostic performance of the model was also compared to that of the state-of-the-art DNN models and five experienced neurosurgeons.

RESULTS

DNN models based on multimodal MRI outperformed single-modal models. ERN-Net achieved the highest AUC in both image-wise (0.915) and subject-wise (0.958) classification tasks. The evaluated DNN models achieved an average sensitivity of 0.947 (SD 0.033), specificity of 0.817 (SD 0.075), and accuracy of 0.903 (SD 0.026), which were significantly better than the tested neurosurgeons (P=.02 in sensitivity and P<.001 in specificity and accuracy).

CONCLUSIONS

Deep learning offers a useful computational tool for the differential diagnosis between recurrent gliomas and necrosis. The proposed ERN-Net model, a simple and effective DNN model, achieved excellent performance on routine MRI scans and showed a high clinical applicability.
Cостояние тиреоидной функции у пациентов с сахарным диабетом 1-го типа и хронической болезнью почек, получающих почечно-заместительную терапию
Authors: Sazonоva A.G. , Mokhort T.V. , Karlovich N.V. , Snapkov V.S. , Valovik O.E. , Ilinchik O.V.
Published: May 2020

Актуальность. Нарушения функции щитовидной железы (ЩЖ) являются распространенной эндокринной патологией среди пациентов с хронической болезнью почек (ХБП), в том числе получающих почечно-заместительную терапию (ПЗТ). Результаты the Third National Health and Nutrition Examination Survey продемонстрировали, что доля пациентов с гипотиреозом возрастает до 23 % при прогрессирующем нарушении функции почек. Цель исследования: изучить влияние ПЗТ на тиреоидную функцию пациентов с сахарным диабетом (СД) 1-го типа и ХБП. Материалы и методы. С целью оценки тиреоидного статуса у пациентов с терминальной ХБП в одномоментное исследование были включены 155 пациентов с СД 1-го типа. В оценке функционального статуса ЩЖ использовались расчетные показатели: индекс периферической конверсии и интегральный тиреоидный индекс (ИТИ). ИПК рассчитывался как отношение свободного Т4 к свободному Т3. Результаты. Не было обнаружено достоверных различий между группами пациентов, получающих ПЗТ, и больных СД 1-го типа с коморбидной ХБП и без нее по уровням общих Т4 и Т3, тиреоглобулина, антител к тиреоглобулину и тиреоидной пероксидазе. Отмечены достоверно более низкие показатели свободного Т4 и свободного Т3 с максимальным снижением при получении ПЗТ. Достоверное снижение уровней антител к рецепторам ТТГ в группе пациентов на ПЗТ в целом, а также после проведения процедуры гемодиализа подтверждает отсутствие влияния аутоиммунного компонента на генез тиреоидных нарушений у пациентов с ХБП и ПЗТ. Определено отсутствие связи между показателями тиреоидного статуса и уровнем компенсации СД 1-го типа у пациентов на ПЗТ, а также между длительностью ХБП и сроками проведения ПЗТ и показателями тиреоидного профиля у пациентов с СД 1-го типа. Выводы. Выявленные изменения предопределяют необходимость оценки уровней сывороточных свободных фракций периферических гормонов ЩЖ, а также проведение гормонального исследования непосредственно после процедуры гемодиализа.
Синдром тиреотоксикоза: новые клинические возможности коррекции тиреоидной дисфункции
Authors: Pankiv V.I.
Published: May 2020

Статья посвящена анализу литературы по изучению спектра терапевтических свойств препарата лапчатки белой, дополненного селеном и цинком, назначающегося в дополнение к стандартному ведению пациентов с гиперфункцией щитовидной железы. В виде монотерапии — при субклиническом тиреотоксикозе первой степени, а также при достижении стойкой компенсации диффузного токсического зоба. В составе комплексной терапии — при субклиническом тиреотоксикозе второй степени, диффузном токсическом зобе при нормализации содержания Т4 и Т3 в крови.