bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of a Clinical Pharmacist in an Interdisciplinary Weight Loss Service: A Follow-Up Study
Authors: Francis Beverly R. , Challen Laura
Published: November 2021

Background: At an Internal Medicine outpatient clinic, patients are referred to a weight loss service by their primary care physician to be managed by a clinical pharmacist and dietician.
Objective: A study was conducted to determine the impact of this established, interdisciplinary, pharmacist-driven weight loss service on percent weight loss from baseline in patients who are obese or overweight compared to those receiving standard weight loss care.
Methods: This was a retrospective, single-center, cohort study including adults ≥18 years of age with BMI ≥30 or BMI ≥27 with at least one weight-related comorbidity such as hypertension, dyslipidemia, or type 2 diabetes mellitus, and referred to the clinic’s weight loss service or managed by their primary care physician. The primary outcome was percent weight loss from baseline. Key secondary outcomes included number of patients who had >5% weight loss in 6 months, number of patients who received liraglutide after 6 months, and percent weight loss in patients prescribed liraglutide. Statistical analysis included descriptive statistics, t-test for continuous outcomes, and chi-square test for between-group differences.
Results: A total of 86 patients met inclusion criteria with 43 patients in the weight loss service group (intervention) and 43 patients in the primary care group (standard care). The intervention group had a significantly higher baseline weight and BMI than the standard care group (120.44 kg vs. 95.72 kg, p <0.001 and 45.34 kg/m2 vs. 37.62 kg/m2, p <0.001 respectively). The percent change in weight from baseline in the intervention group was a decrease of 3% compared to a decrease of 0.35% in the standard care group (p=0.03).
Conclusions: Involvement of clinical pharmacist in interdisciplinary weight loss management through pharmacotherapy and other medication related services, shows considerable improvement in weight loss, when compared to the standard care of weight management. However, prospective randomized studies are warranted to further assess the benefits of a pharmacist-driven, interdisciplinary weight loss service.
Hábitos de sueño en el confinamiento por Covid-19 en una muestra de niños colombianos
Authors: Rosero Bolaños Aldayr David , Ortega Enríquez Germán Emilio
Published: November 2021

La nueva enfermedad provocada por el virus SARS-CoV-2 ha generado en el mundo un confinamiento cuyo fin es ralentizar el número de contagios y proteger así la vida de las personas; sin embargo, tal aislamiento y el cambio de hábitos han producido considerables efectos en su salud mental. Por consiguiente, el presente estudio tuvo como objetivo determinar los problemas en los hábitos de sueño y su relación con algunas características generadas por la reclusión en una muestra de 259 niños colombianos de 5 a 12 años de edad, residentes en la ciudad de Pasto (Colombia), a través de la aplicación a sus padres del cuestionario Children’s Sleep Habits Questionnaire y de un cuestionario ad hoc para evaluar los cambios en las rutinas diarias, el uso de la tecnología y la emocionalidad en los niños. A este efecto, se hicieron análisis descriptivos de los instrumentos, una prueba de X2 para determinar la influencia de las variables de sexo y nivel socioeconómico, y pruebas de correlación rho de Spearman entre las escalas y subescalas de dichos instrumentos. Entre los resultados más relevantes se halló que 45.5% de los niños mostraban algunos problemas del sueño, siendo las parasomnias y la somnolencia diurna los de mayor prevalencia. Además, se encontraron correlaciones positivas entre los puntajes de las escalas, identificándose también relaciones entre el uso de la tecnología y los cambios emocionales con dificultades del sueño, por lo que se concluye que han ocurrido alteraciones en los hábitos de sueño debidos al confinamiento.
Satisfacción con la vida, vitalidad y emociones positivas como factores de protección ante el duelo complicado
Authors: Alonso-Llácer Lorena , Lacomba-Trejo Laura , Pérez-Marín Marián
Published: November 2021

Objetivo: Valorar la satisfacción con la vida, la vitalidad, el afecto positivo y la presencia de duelo complicado en dolientes de primer grado. Método: 26 dolientes de 19 a 73 años, hombres y mujeres, fueron evaluados mediante las Escalas de Satisfacción con la Vida, de Vitalidad y de Afecto Positivo y Negativo, y el Inventario de Duelo Complicado. Se efectuaron análisis descriptivos y se aplicaron las pruebas t de Pearson y d de Cohen para obtener correlaciones entre las variables. Resultados: Los participantes alcanzaron puntuaciones moderadas de satisfacción con la vida, vitalidad y afecto positivo, pero un gran porcentaje mostró duelo complicado, mayor en los hombres y cuando la pérdida había sido repentina. La presencia de tal duelo se asoció con una menor vitalidad y afecto positivo. Discusión: Es necesario conocer los factores de protección para desarrollar programas de intervención que incidan en ellos y favorezcan la salud física y mental de los dolientes.
Diversidade de vespas sociais (Hymenoptera, Vespidae) em um plantio de eucalipto no município de Barreiras, Bahia
Authors: Da Silva Eldair Santos , Franco-Assis Greice Ayra
Published: November 2021

As vespas sociais são insetos de importância ecológica, sendo essenciais no controle biológico em diversos sistemas agrícolas. O objetivo do estudo foi amostrar e analisar a diversidade e abundância da vespifauna em dois talhões de eucalipto, bem como a eficácia dos métodos de captura, no município de Barreiras-BA, durante julho de 2017 a agosto de 2018. As coletas ocorreram mensalmente, por meio de duas metodologias: busca ativa e armadilhas atrativas. Para a análise dos dados, aplicou-se os índices de Shannon-Wiener, Berger-Parker, Constância e Eficiência. Foram coletados 26 indivíduos no TA, e 102 no TB, totalizando 128 vespas, pertencentes a sete gêneros (Agelaia, Brachygastra, Clypearia, Metapolybia, Mischocyttarus, Polistes e Polybia). Polybia foi o gênero mais abundante em ambos talhões, seguido por Metapolybia, Agelaia e Brachygastra. O TA apresentou uma baixa abundância e uma grande diversidade de vespas sociais, já o TB foi mais abundante e menos biodiverso do que o TA. A busca ativa foi o método mais eficaz, seguido pelo método atrativo com maracujá, sardinha e goiaba. Assim, os resultados observados sugerem a necessidade do consórcio de duas ou mais metodologias para mensurar a diversidade e abundância de vespas sociais para que espécies crípticas também possam ser contempladas.
Qualidade de vida de mulheres na Engenharia Civil
Authors: Challouts Caroline Urias , Quevedo dos Santos Natália , Da Silva Tânia Maria Gomes
Published: November 2021

No Brasil, o número de mulheres na área da engenharia civil aumentou consideravelmente nas últimas décadas. Contudo, não há igual relação de crescimento nos cargos de chefia feminina. Acredita-se que isso ocorra devido aos estereótipos de gênero enraizados na sociedade brasileira e que colocam as mulheres em posição de subalternidade.  O menor reconhecimento da capacidade profissional das mulheres, somado a outras barreiras sexistas, pode ter consequências negativas em múltiplos aspectos da vida. O estudo analisou a percepção de engenheiras civis associadas ao CREA-SP acerca do preconceito de gênero na vida profissional. Fundamentou-se na aplicação de questionário abreviado WHOQOL-bref. Os dados foram analisados pelo software Excel Microsoft Corporation, apresentados por meio de gráficos e tabelas. Os resultados apontaram não haver uma relação direta entre inequidades de gênero e qualidade de vida. A pesquisa empírica evidenciou que as entrevistadas apresentavam boa qualidade de vida (627%), com o domínio psicológico apresentando menor escore (58,12%). Evidencia-se a necessidade de aprofundamento acerca da relação entre equidade de gênero e a saúde.
Disfunção temporomandibular em adolescentes e sua relação com hábitos parafuncionais
Authors: Moraes Jorge Amancio Pitta , Marins Gabriela Mazutti , Vargas Junior Carlos Sanches , Franco-Micheloni Ana Lucia , Pizzol Karina Dela Coleta
Published: November 2021

Disfunção temporomandibular (DTM) é um termo que engloba uma série de problemas que afetam a articulação temporomandibular (ATM) e/ou os músculos da mastigação e estruturas associadas. A DTM pode manifestar-se na forma de dor na face e/ou região das ATM, comprometendo significativamente a qualidade de vida do seu portador. Fundamentada na teoria multifatorial da DTM, a literatura evidencia como fatores causais: trauma, hábitos parafuncionais, fatores estruturais, psicológicos e posturais. Embora a DTM possa afetar pacientes de todas as faixas etárias e de ambos os gêneros, seu mecanismo de ação e sua evolução são pouco explorados na fase da adolescência. Assim, este trabalho se propõe a realizar uma revisão da literatura sobre a DTM e sua relação com hábitos parafuncionais em pacientes adolescentes, abrangendo os sinais e sintomas mais prevalentes e o gênero mais atingido por essas disfunções. Foram revisados 67 artigos científicos e livros, utilizando as bases de dados PubMed, LILACs, MEDLINE, ScieELO e Google Acadêmico e as palavras-chave Síndrome da Disfunção da Articulação Temporomandibular; Hábitos e Adolescente; e seus respectivos termos em inglês. De acordo com os artigos revisados, pôde-se concluir que a DTM possui elevada prevalência na população jovem, principalmente no gênero feminino, embora sua fisiopatologia nessa faixa etária ainda seja pouco estudada. Além disso, hábitos parafuncionais, fatores estruturais, psicológicos e posturais podem aumentar a probabilidade de desenvolver sinais e sintomas de DTM.
Análise da produção científica de brasileiros acerca da certificação florestal
Authors: Freire Gabriel de Mello , Heimann Jaqueline de Paula , Da Cunha Letícia Helena Ribeiro
Published: November 2021

Esta pesquisa objetivou levantar dados bibliométricos e de conteúdo sobre artigos publicados que estejam voltados para a certificação florestal no Brasil. Buscou-se dar prioridade a autores brasileiros, mesmo que tenham publicações internacionais, realizando a busca na base de dados da Scopus. Frente a isso, foram registrados 67 artigos relacionados ao tema certificação florestal “forest certification”, nas áreas de Ciências Sociais, Ciências Agrícolas e Biológicas, e Ciência Ambiental, nos quais foram analisados por meio do software VOSViewer®. A análise bibliométrica identificou artigos dos últimos vinte e três anos, bem como os principais autores, instituições, periódicos com mais citações, artigos mais citados, processar as redes de coautoria e cocitação. Elaborados os clusters para identificar as temáticas abordadas, os resultados mostraram uma baixa interação entre autores muito distantes em questão de instituições e diferença temporal, porém uma forte contribuição ao se tratar de autores que pertencem a mesma filiação. O estudo revelou que os autores brasileiros se concentram em uma abordagem voltada para o setor industrial e a preocupação com o impacto ambiental, revelando a necessidade de explorar a questão socioambiental.
Sunomono de Pepino Japonês (Cucumis sativus) e do Pseudofruto de Caju (Anacardium occidentale).
Authors: Shinohara Neide Kazue , da Silva Luciano Canadas , Da Silva Rosely Godoi , Matsumoto Masayoshi
Published: November 2021

O sunomono, conhecida técnica culinária na conservação de alimentos no vinagre, é uma prática antiga e bastante empregada na cultura japonesa, agregando características sensoriais apreciáveis e prolongamento da vida útil das hortaliças. O objetivo da pesquisa foi confeccionar sunomono de pepino e do pseudofruto de caju, alimentos muito apreciados no nordeste brasileiro. Foram realizados ensaios químicos para avaliação nutricional e microbiológica para comprovação de alimento seguro, atendendo legislação vigente no Brasil. Não foi detectado a presença de Escherichia coli, Staphylococcus coagulase positiva ou Salmonella spp. A determinação da composição centesimal de ambos os sunomono informam que o consumo deve ser realizado com cautela, porque o valor calórico e o percentual de carboidratos quando comparado com cada hortaliça in natura, apresentaram concentrações superiores, decorrente da incorporação de sacarose na preparação culinária. Entretanto, é importante observar que foram preservados as concentrações de proteínas e cinzas nas preparações finais em relação as in natura. Portanto, o sunomono se mostra como alternativa culinária viável para preservar hortaliças perecíveis e sazonais, importante grupo alimentar na dieta humana.
Lagos' Bus Stop Names and their Pronunciations by Danfo Bus Conductors
Authors: Obiorah Kenneth
Published: November 2021

Danfo Buses are one of the main means of transportation in Lagos. For commuters to move from one location to another, it is highly essential that they know their bus stops and how the Danfo bus conductors pronounce them.  This is because an inability to understand how these bus stops are pronounced will make it difficult for commuters to locate their destination. This paper aims to classify Lagos bus stop names based on their languages and sources of origin and demystify their pronunciation by Danfo bus conductors. Data was gathered through audio recordings of the speeches of the Danfo bus conductors. Data shows that bus stops in Lagos were named using both the local and English languages. Data also reveals that the names of these bus stops were derived from several ancient landmarks, including religious landmarks, commercial activities, agro-related landmarks, ancient edifices, and long-standing handiwork practices around these bus stops either now or in time past. The data further shows that the Danfo bus conductors employ various phonological processes such as vowel deletion, nasal deletion, vowel lengthening, consonant deletion, and word deletion in the pronunciation of bus stop names. The public is urged to take cognisance of these pronunciations in order not to miss their locations.
Small Group Discussion in Actual ELT Speaking Classes
Authors: Yustina Luli Sari , Besral Besral , Sukandi Syayid Sandi
Published: November 2021

Finding out aspects of learning in small group discussions that matched with the Indonesian Higher Order Thinking Skills (HOTS) and aspects of local cultures that contradict small group discussion excellence is the purpose of this research. The method of this research is qualitative. Researchers use document analysis by collecting documents from various sources such as journals and articles, which are following the research that the researcher will do. The results of this research show that the implementation of HOTS instruction in teaching speaking skills investigated from students’ small group discussions will be advantageous and beneficial. In essence, HOTS instructions give a positive effect on students speaking skills significantly.
Teaching Writing in Blended Environment
Authors: Handoko Handoko , Ayumi Ayumi
Published: November 2021

The article aims to describe the implementation blended learning environment in teaching writing skills. The research is based on the blended learning framework that integrates face-to-face methods and online learning methods. The face-to-face method is given to see students' activeness in delivering ideas and brainstorming before writing essays. The online learning method is used to see students' ability to elaborate ideas from drafting to become a complete essay. Thus, students can be effective in learning in class to discuss their draft an essay and not spend much time writing. The implementation of blended learning was distributed to three session: brainstorming, drafting, and final writing. The evaluation was done for each cycle. After the evaluation, students get feedback for their performance in the previous session. The result post-test shows that students in the experimental class have indicated a significant improvement in essay writing performance with significance 0,06>0,05 with an average score of 76,35. The result of the research is very important as a framework to develop learning models for teaching writing at universities.
Causes and Genomic Approaches to Female Reproductive Failure. Doctoral Thesis
Authors:   ,   Rīga Stradiņš University, Voložonoka Ludmila
Published: November 2021

Clinical recognition of the genetic causes of female reproductive failure using increasingly advancing genetic technologies to preserve patient safety and move towards personalized treatment application is a major challenge of reproductive medicine in the 21st century. The aim of this thesis was to demonstrate a reliable application of advanced genomic techniques in different stages of female reproductive failure in real-life clinical or research scenarios. Several genetic approaches were exploited – starting from the multifactor genetic testing of preimplantation embryos to select the ones free of inherited monogenic conditions and chromosomal aberrations, then following with the analysis of fetal material in case of early pregnancy loss using array comparative genomic hybridization and short tandem repeat analysis to exclude maternal cell contamination, and finally using next generation sequencing technology to analyze genetic landscape leading to preterm delivery in women with cervical insufficiency. The practical work described here was published as three scientific articles now forming three chapters of this thesis. Array comparative genomic hybridization combined with loci-specific genetic testing techniques allowed for a versatile and reliable analysis of preimplantation embryos to select the ones free of genetic conditions analyzed, and in combination with microsatellite analysis it also allowed to access the chromosomal causes of early pregnancy loss while reducing the misdiagnosis caused by maternal cell contamination. Next generation sequencing application allowed to identify the disruptive variants potentially contributive to the development of non-syndromic cervical insufficiency. Pathway enrichment analysis of variant genes from our cohort revealed an increased variation burden in genes playing roles in tissue mechanical and biomechanical properties. Literature analysis allowed to conclude that number of genes can be reliably attributed to female reproductive failure and an increasing number of genes form a pool of good candidates. In order to develop diagnostic gene panels and facilitate genetic advancement inclusion in the clinical practice of female reproduction, a standardized clinical gene-disease validity assessment of the identified genes has to be performed and best practice guidelines have to be composed.
Formação pedagógica na enfermagem: reflexão para a prática
Authors: Silva Rosilene da , Jacinto Regina Racquel dos Santos , Pereira Rogério Gomes
Published: November 2021

Objetivo: Apresentar uma reflexão para a importância da formação pedagógica para docentes de ensino superior em enfermagem. Revisão bibliográfica: A formação pedagógica de professores para o nível superior tem representado uma nova roupagem para a formação profissional, novas tecnologias têm sido utilizadas no auxílio do desenvolvimento das competências dos formadores. Estudos têm mostrado que o processo de ensino do cuidar precisa superar o modelo tradicional e tecnicista, buscar a ressignificação da prática pedagógica e romper com abordagens conservadoras, tendo em vista que cada vez mais é preciso ensinar e aprender, conceitos esses que de longe parecem fáceis, sobretudo nos tempos atuais em que os profissionais precisam refletir sobre o seu cotidiano com maior profundidade, haja vista tantas transformações do contexto vivido, um desafio constante. Considerações finais: A literatura mostra que o profissional enfermeiro precisa ser um pesquisador da própria prática e a formação do docente enfermeiro precisa ser redirecionada na reflexão da prática cotidiana. Assim sendo considera-se a reflexão sobre a formação e expansão de cursos necessária, assim como, pertinente saber quem serão os atores que responderão pela formação e, inclusive qual a preocupação que existe para remover barreiras para a aprendizagem.
Rapid Efficacy of Ixekizumab for Pediatric Acute Generalized Pustular Psoriasis
Authors: Serrano Linda , Carlberg Valerie , Holland Kristen
Published: November 2021

Introduction: Generalized pustular psoriasis (GPP) is a rare, severe variant of psoriasis that is uncommon in pediatric patients and can be refractory to many therapies. Ixekizumab, a monoclonal antibody that selectively inhibits interleukin 17-A, has been reported as safe and efficacious in patients with GPP, though minimal data exists on its use in the pediatric population.

Case presentation: A 17-year-old female with history of alopecia areata and pustular psoriasis, on ustekinumab, was admitted for a severe pustular psoriasis flare with systemic symptoms including fever and tachycardia which progressed to erythroderma and required vasopressor support. After minimal improvement with 24 hours on broad-spectrum antibiotics, she received cyclosporine 5mg/kg/day. On day three of admission, and after two days of cyclosporine with minimal improvement, she received a 160 mg loading dose of ixekizumab. She defervesced and transferred out of the ICU within 24 hours. She was successfully weaned off cyclosporine after her second dose of ixekizumab. She experienced no adverse reactions.

Discussion: Generalized pustular psoriasis is less common and often more severe than plaque psoriasis, associated with increased morbidity and mortality in both pediatric and adult patients. Clinical trials and case series have reported rapid and sustained improvement in patients with pustular psoriasis refractory to other therapies, though there is little data on the pediatric population. This case demonstrates the rapid efficacy of ixekizumab for severe erythrodermic pustular psoriasis in a pediatric patient, highlighting its use not only for refractory disease, but also as a rescue therapy in an emergent setting.
Diffuse Large B-cell Lymphoma in Bilateral Lower Extremities
Authors: Kou Leon , Niu Kevyn , Wong Austin , Chen Aaron , Danesh Sid
Published: November 2021

Diffuse large B-cell lymphoma, leg type, is a rare variant of primary cutaneous B-cell lymphomas.  It typically presents as rapidly enlarging solitary or multiple violaceous nodules on the lower extremities.  Even with adequate treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, recurrence and systemic spread is common.  Timely treatment is necessary as this malignancy is associated with a more aggressive course than other variants of primary cutaneous B-cell lymphomas and overall prognosis is poor.
Thousand Words for a Picture of Health
Authors: Blake Amy
Published: November 2021

Abstract not available.
Social Media and Skin Cancer Prevention: A Promising Platform for Education Among Adolescents and Young Adults
Authors: Cavanagh Mary , Chellappan Brinda
Published: November 2021

Abstract not availalbe.
Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Efficacy by Baseline Disease Characteristics and Demographics in Two Pivotal Phase 3 Trials
Authors: Kircik Leon , Stein Gold Linda , Del Rosso James , Desai Seemal , Glick Brad , Sofen Howard , Tallman Anna , Rubenstein David , Brown Philip
Published: November 2021

N/A
Once-Daily Roflumilast Cream 0.3%, a Potent Phosphodiesterase-4 Inhibitor, Provided Safe and Effective Treatment of Psoriasis in the DERMIS-1 and DERMIS-2 Phase 3 Trials
Authors: Lebwohl Mark , Kircik Leon , Moore Angela , Stein Gold Linda , Del Rosso James , Draelos Zoe , Gooderham Melinda , Green Lawrence , Herbert Adelaide , Papp Kim , Bagel Jerry , Bhatia Neal , Ferris Laura , Jones Terry , Kempers Steve , Pariser David , Yamauchi Paul , Zirwas Matthew , Feng Amy , Burnett Patrick , Higham Robert , Berk David
Published: November 2021

N/A
Long-term Safety and Efficacy of Fixed-Combination Halobetasol Propionate and Tazarotene Lotion in Patients With Clinically Meaningful Improvement in Plaque Psoriasis
Authors: Alexis Andrew , Del Rosso James , Bhutani Tina , Papp Kim , Jacobson Abby
Published: November 2021

N/A
Long-term Outcomes of Fixed-Combination Halobetasol Propionate and Tazarotene Lotion Stratified by Baseline Signs and Symptoms of Psoriasis
Authors: Kircik Leon , Green Lawrence , Zeichner Joshua , Alonso-Llamazares Javier , Jacobson Abby
Published: November 2021

N/A
Bimekizumab response maintenance through two years of treatment in patients with moderate to severe plaque psoriasis who responded after 16 weeks: Interim results from the BE BRIGHT open-label extension trial
Authors: Strober Bruce , Asahina Akihiko , Mrowietz Ulrich , Lebwohl Mark , Foley Peter , Langley Richard , Barker Jonathan , Cioffi Christopher , Cross Nancy , Wang Maggie , Paul Carle
Published: November 2021

N/A
Number Needed to Treat Among Therapies for Patients with Moderate to Severe Plaque Psoriasis: Clinical Perspective of Results from a Network Meta-Analysis
Authors: Leonardi C , Fahrbach K , Neupane B , Armstrong A , Gordon K , Kiri S , Taieb V , McClung L
Published: November 2021

N/A
Assessing long-term maintenance of efficacy with tralokinumab monotherapy in patients with moderate-to-severe atopic dermatitis: combined results from two phase 3, randomized, double-blind, placebo-controlled trials (ECZTRA 1 and 2)
Authors: Blauvelt Andrew , Wollenberg Anderas , Pink Andrew , Peris Ketty , Armstrong April , Spelman Lynda , Saeki Hidehisa , Lynde Charles , Herranz Pedro , Barbarot Sebastien , Simpson Eric
Published: November 2021

N/A
Long-Term Improvements Observed in Tralokinumab-Treated Patients with Moderate-to-Severe Atopic Dermatitis: an ECZTEND Interim Analysis
Authors: Blauvelt Andrew , Lacour Jean-Philippe , Toth Darryl , Laquer Vivian , Beissert Stefan , Wollenberg Andreas , Herranz Pedro , Pink Andrew , Peris Ketty , Fangel Stine , Saeki Hidehisa
Published: November 2021

N/A
Rapid and sustained improvements in itch and sleep with tralokinumab treatment in patients with moderate-to-severe Atopic Dermatitis, a post hoc analysis of pooled data from ECZTRA 1 and 2
Authors: Simpson Eric , Wollenberg Anderas , Soong Weily , Mark Thomas , Kuznetsova Alexandra , Abildgaard Steffensen Louise , Silverberg Jonathan
Published: November 2021

N/A
Long-Term Safety and Disease Control With Ruxolitinib Cream in Atopic Dermatitis: Results From Two Phase 3 Studies
Authors: Papp Kim , Szepietowski Jacek , Kircik Leon , Toth Darryl , Eichenfeld Lawrence , Forman Seth , Kuligowski Michael , Venturanza May , Sun Kang , Simpson Eric
Published: November 2021

N/A
Tazarotene 0.045% Lotion for Acne: Formulation, Application Characteristics, and Clinical Efficacy and Safety
Authors: Draelos Zoe , Tanghetti Emil , Stein Gold Linda , Baldwin Hilary , Kircik Leon , Guenin Eric
Published: November 2021

N/A
Investigating Treatment of Primary Axillary Hyperhidrosis With a Topical Retrometabolic Anticholinergic Drug
Authors: Bodor Nicholas , Friedman Adam , Smith Stacy , Del Rosso James , Dubois Janet , Herbert Adelaide , Sullivan Tory , Rice Zakiya , Gorlick Joe , Kircik Leon , Green Lawrence , Kirsch Brandon , Chadha Deepak
Published: November 2021

N/A
The Cataylst Initiative: Innovative CME on Appropriate Use of Immunotherapy in the Systemic Treatment of Locally Advanced and Metastatic BCC and cSCC
Authors: Learning Group Med
Published: November 2021

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Field Treatments for Actinic Keratosis: A Systematic Review and Network Meta-Analysis
Authors: Martin G , Berman B , Feldman S , Armstrong A , Edwards M , Graziadio S , McCool R , Arber M , Carr E , James D , Chapman-Rounds M , Fumero E , Schuchardt M , Grada A
Published: November 2021

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Stabilized Cysteamine 5% Cream for the Treatment of Senile Lentigo
Authors: Saki Nasrin
Published: November 2021

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VARIABILITY OF BLOOD PRESSURE IN COMORBIDITY OF ARTERIAL HYPERTENSION AND ATRIAL FIBRILLATION
Authors:   Zaporizhia Medical Academy of Post-graduate Educatio, Zaporizhia, Ukraine, Boev S. S. , Dotsenko N. Ya. ,   Zaporizhia Medical Academy of Post-graduate Educatio, Zaporizhia, Ukraine, Shekhunova I. A. ,   Zaporizhia Medical Academy of Post-graduate Educatio, Zaporizhia, Ukraine, Gerasimenko L. V. ,   Zaporizhia Medical Academy of Post-graduate Educatio, Zaporizhia, Ukraine, Yatsenko O. V. ,   Zaporozhia State Medical University, Zaporizhia, Ukraine, Lyubitov D. Yu. ,   City Emergency Hospital, Kamianske, Ukraine
Published: November 2021

Background. Arterial hypertension plays a decisive role in the development of atrial fibrillation, being the most important risk factor. Purpose. Analyze the literature on modern concepts of the relationship between blood pressure variability and atrial fibrillation. Material and methods. We analyzed 53 literature sources. Results. Information about the modern mechanisms of atrial fibrillation formation in arterial hypertension has been obtained. Approaches to the choice of antihypertensive therapy in patients with arterial hypertension and atrial fibrillation have been described. Conclusions. Based on the studies presented in the literature, it was found that blood pressure variability has an additional contribution to cardiovascular risk. Reducing blood pressure variability can be added as one of the important strategies in the treatment of arterial hypertension and atrial fibrillation.
ASSESSMENT OF POPULATION IMMUNITY TO THE SARS-COV-2 VIRUS AMONG THE POPULATION OF GRODNO
Authors:   Grodno State Medical University, Grodno, Belarus, Krotkova E. N. , Kuznetsov O. E. ,   Grodno State Medical University, Grodno, Belarus, Gorchakova O. V. ,   Grodno State Medical University, Grodno, Belarus
Published: November 2021

In Grodno, as well as in the Republic of Belarus as a whole, vaccination of the population against COVID-19 infection is being actively carried out. Purpose of the study: To assess population immunity to the SARS-CoV-2 virus among the population of the city of Grodno. The material of the study was the blood sera of 422 patients, residents of Grodno. Results. Among the studied subjects 32.7% (n=138) of cases had the level of class G antibodies to the receptor-binding domain (RBD) of the S protein (hereinafter RBD of the S protein) which was higher than 1.1 units of the positivity coefficient. A high seropositivity index (40.4%) was established among people who had not previously been infected with COVID-19 and were vaccinated with Sputnik V, the lowest – in the group of people who had not been infected with the infection and were not vaccinated – 25%. The assessment of the antibodies concentration adjusted for the age of the subjects did not reveal significant changes in their level. As regards the time interval, it was found that those individuals, who were vaccinated with Sputnik V vaccine regardless of whether they had been ill or not with COVID-19 infection before, had the highest level of antibodies within the second month after the last dose of the vaccine, which decreased by the fourth month after vaccination and remained at this level for up to six months.
EFFECTS OF NEW PIPERIDINE DERIVATIVES WITH SUBSTITUTIONS IN THE 1ST AND 4TH POSITIONS IN NALOXONE SENSITIVE ANALGESY
Authors:   Grodno State Medical University, Grodno, Belarus, Vasilyuk A. A. , Kozlovsky V. I. ,   Grodno State Medical University, Grodno, Belarus, Akhmetova G. S. ,   A. B. Bekturov Institute of Chemical Sciences, Almaty, Kazakhstan, Yu V. K. ,   A. B. Bekturov Institute of Chemical Sciences, Almaty, Kazakhstan
Published: November 2021

Background. Despite the wide arsenal of painkillers, pain relief is an urgent interdisciplinary problem that requires a search for new solutions. Purpose of the study. To establish the role of opioid receptors in the mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23. Material and methods. The studies were carried out on 96 white mice of both sexes weighing 30-40 g. The analgesic effect of the compounds was tested on models of thermal and chemical irritation with preliminary administration of the opioid receptor antagonist naloxone. Results. The pain reactions of mice with models of thermal and chemical stimulation in the AGV-22 / AGV-23 + naloxone and AGV-22 / AGV-23 groups were comparable. Conclusions. The mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23 is not associated with the activation of opioid receptors.
Comparación de técnicas basadas en visión computacional y machine learning para la detección temprana de anemia a partir del análisis de uñas
Authors: Heredia-Menor Keico Anavela , Mamani-Ticona Wilfredo
Published: November 2021

En el Perú la anemia es una enfermedad que está presente en más del 40 % de la población, es común tanto en niños como en adolescentes, y predomina en mujeres gestantes y niños menores de dos años, lo que compromete seriamente su desarrollo. Para diagnosti car la anemia es necesario realizar pruebas de laboratorio mediante el análisis de la sangre, donde se determinan los niveles de hemoglobina. Sin embargo, la mayoría de los hospitales no cuentan con los equipos adecuados para realizar las pruebas, lo que ocasiona retrasos en la entrega de los diagnósticos. El objetivo de esta investigación es comparar técnicas basadas en visión computacional y machine learning para la detección temprana de anemia a partir del análisis de uñas, de manera que los doctores puedan utilizarlo como apoyo en la detección de la anemia para un descarte temprano. Con un diagnóstico oportuno, se evitará a los pacientes padecer las diferentes etapas de esta enfermedad y especialmente a los que se encuentran en la etapa crónica cuando las consecuencias son graves, debido a que la anemia puede indicar la presencia de otra enfermedad subyacente. Se realizaron varios experimentos y los mejores resultados fueron: Accuracy 0,989, precision 0,98, recall 0,98 y F1-score de 0,98, con la arqui tectura VGG19 como extractor de características en combinación con el clasificador support vector machines (SVM). Con la investigación se demostró que es posible detectar la anemia, sin necesidad de un análisis de sangre, con mayor rapidez y con resultados confiables.
Tecnología como impulsora del desarrollo sostenible: una mirada desde la investigación
Authors: Estrada Alfredo
Published: November 2021

Tomando como punto de partida el contexto actual y reflexionando sobre la mane ra en que se debe construir la nueva normalidad de la que se hace mención actualmente, el presente artículo pone a consideración los principales hitos en los que debe basarse esta cons trucción, que debe ser de carácter transformador. En ese sentido, se identifica a la tecnología como una de las contribuciones más importantes para el impulso hacia el desarrollo soste nible, se establece preliminarmente la relación “desarrollo tecnológico-desarrollo sostenible”; esto último es producto de una revisión documentaria basada en la agenda 2030, en estudios académicos y científicos sobre tecnología, inteligencia artificial y su relación con los objetivos de desarrollo sostenible. Como resultado, se resalta el rol de la academia como motor de los avances científicos para el desarrollo tecnológico y la sostenibilidad. Finalmente, se presentan insumos potenciales de investigación en campos como tecnologías responsables, desarrollo sostenible basado en la tecnología, entre otros. Lo que se pone en evidencia es la necesidad de investigar la sostenibilidad como un sistema compuesto de tres dimensiones interdependien tes: una dimensión natural, una dimensión humana y una dimensión tecnológica.
Prognostic factors for the carbohydrate metabolism normalization in patients with type 2 diabetes mellitus and obesity using liraglutide 3.0 mg per day
Authors: Sklyanik Igor A. , Shestakova Marina V.
Published: November 2021

Background. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are innovative drugs that effectively reduce glycemic levels and overweight in patients with type 2 diabetes mellitus (T2DM). However, the criteria for predicting the hypoglycemic effect of this group of drugs have not been practically defined.
Aim. To assess the factors contributing to the achievement the glycemia normalization in patients with diabetes mellitus and obesity by adding to antihyperglycemic therapy (AT) a drug from the GLP-1 RA group liraglutide 3.0 mg per day.
Materials and methods. A single-center, prospective, non-randomized study was provided. The objects of the study were patients with T2DM and obesity (n=22). Liraglutide 3.0 mg per day was added to the current AT of patients. Initially, the parameters of carbohydrate metabolism, hormones of the incretin system on an empty stomach and during the mixed-meal test, insulin resistance using the euglycemic hyperinsulinemic clamp test, and body composition were studied. After 9 months of therapy, all studies were repeated and a search for possible predictors of the carbohydrate metabolism normalization was made.
Results. The body mass index of patients decreased from 42.4 [37.7; 45.0] to 35.9 [33.0; 40.9] kg/m2. Fasting blood glucose and glycated hemoglobin levels decreased from 9.02 [7.40; 11.37] mmol/L and 7.85 [7.43; 8.65]% up to 5.90 [5.12; 6.18] mmol/L and 6.40 [5.90; 6.60]%, respectively. 14 (63.6%) patients reached normoglycemia. Insulin resistance according to the clamp test did not change over the study. Basal concentrations of oxyntomodulin, glycentin and the area under the GLP-1, oxyntomodulin, glycentin curve significantly decreased 9 months after liraglutide administration. The prognostic marker of the achievement of normoglycemia during therapy with liraglutide 3.0 mg/day is the level of endogenous GLP-15.5 pmol/L before the appointment of arGPP-1 therapy.
Conclusion. The concentration of endogenous GLP-1 before the appointment of liraglutide therapy at a dose of 3.0 mg per day can be used for prediction the drug hypoglycemic effect and achieving normoglycemia possibility.
The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation
Authors: Suplotova Lyudmila A. , Avdeeva Valeria A. , Pigarova Ekaterina A. , Rozhinskaya Liudmila Ya. , Karonova Tatiana L. , Troshina Ekaterina A.
Published: November 2021

Aim. To assess the incidence of vitamin D deficiency and insufficiency among the adult population living in the regions of the Russian Federation located at latitudes from 45 to 70.
Materials and methods. Russian multicenter non-interventional registry study using the "cross-sectional" method.
Results. In this study, 72.1% of the examined have the status of vitamin D deficiency and insufficiency, while an adequate level was diagnosed in 27.8% of cases. When assessing the degree of vitamin D deficiency depending on the season, statistically significant differences (p0.00001) were found between the periods: vitamin D deficiency or insufficiency was observed in 84.2% of autumn and in 62.4% of spring. The highest incidence of vitamin D deficiency and insufficiency was recorded in males compared with females (p=0.013, 79 and 70.3% respectively). Vitamin D deficiency is observed in young people in the age subgroup of 1825 years (p0.001, 54% in the study as a whole) much more often than in older people
Conclusion. The widespread high prevalence of vitamin D deficiency in the Russian Federation is not related to geographic region of residence, but to some extent depends on the season. The high-risk group for vitamin D deficiency and insufficiency is young men. The significant role of vitamin D in the human body justifies the need to supplement and clarify a single concept for the prevention, diagnosis and treatment of conditions associated with deficiency, so higher implementation of National Clinical Guidelines is needed.
EFFECTS OF DROUGHT STRESS ON THE PHYSIOLOGY AND YIELD OF THE MAIZE: A REVIEW
Authors: Pokhrel Shobha
Published: November 2021

Maize is a cereal crop mainly cultivated in arid and semi-arid regions, where drought stress due to changing environment is affecting crop growth, development and yield. The aim of this literature review is to offer discourse on different physiological changes, germination and yield performance of maize under stressful environment of drought. The stressful environment due to water deficit causes a great alteration in a wide range of the physiological, biochemical and molecular process in maize which ultimately causes negative effect in yield. Drought stress influence in growth, development, yield and quality of the crop with impairment in the plant height, leaf area and biomass. A great variation in the photosynthetic process due to reduction in the photosynthetic pigments (chlorophyll a, chlorophyll b), stomatal conductance, photosystem activity, enzymes occur under water deficit condition in maize. Drought induce reduction in the soil moisture which results an unbalanced concentration of macro and micro nutrients leading to nutrient deficiency in plant. Maize is susceptible to drought during germination. Drought stress limits the germination process and early seedling growth. The severe and prolonged drought duration hampers more in reproductive stage during anthesis period than vegetative stage affecting final grain yield in maize crop.
STATUS OF CAPITAL ASSETS FOR AGRICULTURAL SUSTAINABILITY IN GANGAJAMUNA RURAL MUNICIPALITY DHADING, NEPAL
Authors: Phago Sunita , Mishra Sharoj Raj , Panta Hari Krishna , Khanal Subodh
Published: November 2021

Capitals for agricultural sustainability include human, physical, natural, financial and social aspects present in agroecosystem. The status about these capitals provide base for sustainability in agriculture. In this regard, a descriptive research was done to record the status of capital assets needed for agricultural sustainability in Gangajamuna Rural Municipality of Dhading district. The study was based on primary data collected through structured questionnaire based on simple random sampling technique from 57 farming-based household samples during April, 2018. The study provided an overview on status of capital assets which must be taken into consideration for paradigm shift in current set of agricultural practices for achieving agricultural sustainability. The status of human, physical and financial capitals were poor in comparison to nature and social capitals. The study concluded that the state of farming practices, technologies and management system must be upgraded for ensuring agricultural sustainability and increasing adaptive capacity and transformability in order to thrive in the present context.
ADOPTION OF SMALL-SCALE IRRIGATION TECHNOLOGIES FOR VEGETABLE PRODUCTION BY FARMERS IN NASARAWA STATE, NIGERIA
Authors: D Bello , AO Agwale , S Moren , YW Laminu
Published: November 2021

The research was conducted to assess the adoption of small-scale irrigation technologies for vegetable production by farmers in Nasarawa State. A multi-stage random sampling techniques was adopted on selecting three (3) local government each from the three agricultural zones in the state namely; Nasarawa North, Nasarawa south and Nasarawa west to give a total number of nine (9) local government that was used for the study, from each of the nine (9) selected local government, fifteen (15) small-scale farmers were randomly selected to give a total number of one hundred and thirty five (135) respondents that was used for the study. Data were collected and analyzed using simple descriptive statistics such a frequency count, mean score, percentage score and standard deviation to satisfied all the objectives. Instrument for data collection was administered through a well structured questionnaire and oral interview. The instrument cover all the objectives of the study. The major findings revealed that majority of the respondents (63%) were full-time farmers while (37%) were engaged in other forms of occupation. The result also indicate that majority (41%) of the respondents fall within the ages of 21 – 30yrs (30%) falls within the ages of 31 – 40yrs (15%) falls within 1 – 20yrs and (7.4%) falls within 51 and above. The findings revealed that (66%) of the respondents are male while (34%) are female. The result also shows that (70%) of the respondents are married while (37%) are single. The findings revealed that majority (46.66%) of the respondents uses stream as the source of water supply (27%) uses dams and (19%) uses rivers (7.40%) uses canals.
Avaliação da qualidade fisiológica de sementes de cultivares de trigo de diferentes partes da espiga
Authors: Felipim Ferrazza Felipe Leandro , Udich Alex , Toledo Borges Gabriel , Tiago Kanieski Jacoboski Douglas , Mantovani Tolfo Maico , Tadeu Paraginski Ricardo
Published: November 2021

O bom estabelecimento de uma lavoura de trigo e o desempenho inicial das plantas são de extrema importância para elevação dos índices de produtividade da cultura. Neste sentido, a qualidade fisiológica das sementes é de extrema importância para a implantação de lavouras com maior crescimento inicial de plantas, desempenho e uniformidade das plantas e produtividade de grãos. Assim, pensando em melhorar a qualidade de sementes disponíveis para utilização no mercado local, o objetivo no trabalho foi avaliar a qualidade de sementes de diferentes cultivar de trigo da parte superior e inferior da espiga. Foram utilizados 12 cultivares de trigo produzidas na safra 2018, onde após a maturação fisiológica foram colhidas e tiveram a espiga dividida em parte superior e inferior, sendo debulhadas e após submetidas aos testes de germinação, peso de mil grãos, comprimento de plântulas e massa de plântulas. Os resultados indicam que a parte inferior das espigas apresenta maior peso de mil sementes e maior massa seca de plântulas, já as sementes da parte superior da espiga tiveram um maior teor de germinação. Portanto, existe diferença na qualidade de sementes de diferentes partes da espiga, porém novos trabalhos precisam ser realizados e também métodos de colheita desenvolvidos com essa finalidade.