bluuebunny/crossref_metadata_2025 huggingface dataset:
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
Authors: Sun Yan , Jin Xin , Meng Junpeng , Guo Feng , Chen Taoyu , Zhao Xiaoyan , Wu Heshui , Ren Dianyun
Published: October 2023

The Hippo signaling axis is a tumor suppressor pathway that is activated by various extra‐pathway factors to regulate cell differentiation and organ development. Recent studies have reported that autophosphorylation of the core kinase cassette stimulates activation of the Hippo signaling cascade. Here, we demonstrate that protein arginine methyltransferase 5 (PRMT5) contributes to inactivation of the Hippo signaling pathway in pancreatic cancer. We show that the Hippo pathway initiator serine/threonine kinase 3 (STK3, also known as MST2) of Hippo signaling pathway can be symmetrically di‐methylated by PRMT5 at arginine‐461 (R461) and arginine‐467 (R467) in its SARAH domain. Methylation suppresses MST2 autophosphorylation and kinase activity by blocking its homodimerization, thereby inactivating Hippo signaling pathway in pancreatic cancer. Moreover, we also show that the specific PRMT5 inhibitor GSK3326595 re‐activates the dysregulated Hippo signaling pathway and inhibits the growth of human pancreatic cancer xenografts in immunodeficient mice, thus suggesting potential clinical application of PRMT5 inhibitors in pancreatic cancer.
Challenges and Recommendations in Building the Teaching Force for Rural Compulsory Education in China
Authors: Li Rongkai
Published: October 2023

High-quality teaching staff is one of the key factors in the advancement of Chinese compulsory education. The purpose of this article is to pinpoint issues with teacher recruitment, retention, and training in rural areas, such as unbalanced employment mobility, unreasonable composition of staff, and impeded teacher professional development. Recommendations on improving rural school staffing are also made in the dimensions of government policies, in-service training, and social support.
Yacimientos simulados y arqueología experimental como herramienta de aprendizaje en Arqueología y Paleontología
Authors: Dur´an Isabel , Baena Javier , Cambra-Moo Óscar , González-Martín Armando , Castañeda Nuria , Torres Concepción
Published: October 2023

La arqueología Experimental ha tenido una amplia difusión tanto en el ámbito investigador como en el divulgativo en las últimas décadas. No obstante, su empleo en la generación de modelos arqueológicos simulados ofrece un recurso de enorme potencialidad para poder profundizar en el campo de la interpretación del registro arqueológico. En este trabajo, presentamos un primer acercamiento a las simulaciones arqueológicas sobre base experimental con especial atención a los modelos creados en el LAEX-UAM. Igualmente exploramos su potencial dentro del campo de la interpretación del registro arqueológico.
Arqueología experimental con huellas humanas en yeso
Authors: González López Rodrigo
Published: October 2023

En este proyecto se analizan estudios experimentales previos sobre huellas humanas y se realizan una serie de experimentaciones usando yeso. Se realizan unas huellas caminando, otras cargando peso y otras corriendo para analizar las diferencias que estas tienen entre sí y compararlas con las huellas de homínido más antiguas encontradas, las de Laetoli.
Effects of nanoparticle applications on seedling survival and morphological characteristics in Scots pine afforestation
Authors: Ayan Sezgin , Yer Çelik Esra Nurten , Gülseven Orhan , Yer Batın Mehmet , Eskiömer Muhammed
Published: October 2023

This study was conducted in the afforestation area, using bare-root 2+0-year-old Scots pine seedlings from Kastamonu. The study aimed to determine the impact of nanoparticle (NP) applications on seedling morphological characteristics and seedling survival success. Three different concentrations (low, medium, high) and four different nanoparticle types [Fe₃O₄, CuO, ZnO, TiO2] were applied to the plant root-dipping method in the study. The effects of NP treatments on seedling height (SH), root collar diameter (RCD), stem fresh weight (SFW), root new weight (RFW), seedling fresh weight (SEFW), root dry weight (RDW), stem dry weight (SDW), seedling dry weight (SEDW), sturdiness quotient (SI), root: shoot ratio (R/S), and seedling survival in the field were evaluated. The study results revealed that NP types significantly affected all seedling variables except RFW, SDW, RDW, and SEDW, and NP doses significantly affected all seedling variables except RFW. The binary interaction effects of NP types and doses had a significant effect on all seedling variables, and higher values were obtained compared to the control treatment. Medium and high NP doses were more effective in seedling growth than low doses; the percentage of seedling survival was 61.4% in the control treatment and 95% in the TiO2-Medium NP treatment combination.
Psichinės pajamos ir jų šaltiniai socialiniame darbe
Authors: Idaitė Monika , Daunytė Agnė , Dunčytė Ugnė , Gudienė Goda , Jogielaitė Evelina , Meištaitė Greta , Vaitkevičiūtė Lina , Venckutė Gabrielė
Published: October 2023

Work is a mental and physical activity performed in order to receive a reward, which is usually understood as money. However, people work in a variety of jobs, and their job choices are not driven only by financial income. When working, we also receive psychic income – respect, gratitude, emotions, various experiences, and feelings. Psychic income is largely analyzed by economists and psychologists. In social work, as in medicine or pedagogy, psychic income is a significant part of the total income. The goal of the study is to identify sources of psychic income in social work. In order to determine the sources, a model of possible sources was constructed. The model is based on the ideas of Coleman, Bandura and Zukerman. The data for the test of the model was collected by surveying social workers. After the analysis, it can be stated that there are differences in psychic income between social workers depending on the sector they work in; statistically significant results were found in the case of social workers working in NGOs. The main sources of mental income are self-efficacy and the challenges and emotional experiences at work. Research also revealed that there are contradictions regarding the realization of power in social work as a source of psychic income, which requires additional research.
Šeimos politika ir vienų motinų šeimų stigmatizacija
Authors: Skubiejute Greta
Published: October 2023

This article investigates the stigmatisation of single-mother families in Lithuania’s family policy through qualitative legal document content analysis and semi-structured interviews with single mothers. It reveals historical policy biases favouring nuclear families, resulting in marginalised single-mother households despite recognising their economic challenges. Analysis of single mothers’ experiences shows how stigmatization negatively impacts these families’ well-being and political representation, hindering rights advocacy.
Analyzing Hot Bugs in the Linux Kernel by Clustering Fixing Commit Messages
Authors: Starovoytov Nikita Alexandrovich , Golovnev Nikolay Andreevich , Staroletov Sergey Mikhailovich
Published: October 2023

In system software environments, a vast amount of information circulates, making it crucial to utilize this information in order to enhance the operation of such systems. One such system is the Linux kernel, which not only boasts a completely open-source nature, but also provides a comprehensive history through its git repository. Here, every logical code change is accompanied by a message written by the developer in natural language. Within this expansive repository, our focus lies on error correction messages from fixing commits, as analyzing their text can help identify the most common types of errors. Building upon our previous works, this paper proposes the utilization of data analysis methods for this purpose. To achieve our objective, we explore various techniques for processing repository messages and employing automated methods to pinpoint the prevalent bugs within them. By calculating distances between vectorizations of bug fixing messages and grouping them into clusters, we can effectively categorize and isolate the most frequently occurring errors. Our approach is applied to multiple prominent parts within the Linux kernel, allowing for comprehensive results and insights into what is going on with bugs in different subsystems. As a result, we show a summary of bug fixes in such parts of the Linux kernel as kernel, sched, mm, net, irq, x86 and arm64.
Antoni MATABOSCH I SOLER, El peregrinaje ecuménico. Del Vaticano II a nuestros días, Barcelona: Centre de Pastoral Litúrgica («Emaús», 173), 2023, 244 pp., 12 x 19, ISBN 9788491655435.
Authors: Blanco Pablo
Published: October 2023

Book Review
Clinical Impact on Dental Implant Survival in Patients Taking Antiresorptive Medications: A Systematic Review and Meta-Analysis
Authors: Ting Miriam , Huynh Benzon H. , Woldu Henok G. , Gamal Ibrahim , Suzuki Jon B.
Published: October 2023

Dental implants are a predictable option to replace missing teeth. Patients on antiresorptive medications used to treat disorders associated with bone resorption may need dental implants to replace missing teeth. The data on implant failure in patients on antiresorptive medication requiring dental implants, is conflicting and limited. This systematic review aims to investigate if antiresorptive medications have any clinical impact on dental implant survival. Electronic databases were searched until May 2020. The focus question (PICOS): Participants: humans, Interventions: implant placement surgery in patients on antiresorptive medication, Comparisons: patients on antiresorptive medication vs control (patients not on antiresorptive medication), Outcomes: implant survival, and Study design: clinical studies. The protocol of this systematic review was registered in PROSPERO (CRD42020209083). Fourteen nonrandomized studies were selected for data extraction and risk of bias assessment using the ROBINS-1 tool. Only studies with a control were included for the meta-analysis, 8 articles were included in the meta-analysis using implant-level data, and 5 articles were included in the meta-analysis using patient-level data. There was no statistical significance between the 2 groups at the patient level based on 265 patients. However, there was a statistically significant difference at the implant level based on 2697 implants. Therefore, antiresorptive medications, mainly bisphosphonates (BPs), may significantly contribute to implant failure. Antiresorptive medications, especially BPs may reduce implant survival and impair the osseointegration of dental implants. Failed implants in patients on BPs may not lead to osteonecrosis and may be replaced with success.
DEVELOPMENT OF FLOUR COMBINED SYSTEMS WITH IMPROVED AMINO ACID COMPOSITION
Authors: Matveeva T. , Papchenko V. , Petik P. , Khareba V. , Khareba O.
Published: October 2023

Questions of mathematical calculation of combined flour systems with improved amino acid composition have been studied. To create such systems, it is proposed to use secondary products of oilseeds processing – meal, namely soybean, linseed and sunflower. The expediency of using the indicated meals is substantiated. It is emphasized that in order to create scientific foundations and practical directions for the use of new raw materials in the production of flour products, comprehensive studies are needed to study its composition, physical and chemical properties, as well as the impact on the quality of finished products. The amino acid composition of the proteins of these meals and wheat flour was experimentally determined. Calculated amino acid score. Particular attention is paid to the mathematical calculation of the composition of oilseed meal, which, in terms of amino acid composition, is as close as possible to the reference protein. The mass fractions of soybean, flaxseed and sunflower meal proteins in the composition were determined, namely: 0.51, 0.2 and 0.29, respectively. The amino acid composition and the biological value of the protein of the obtained meal composition were established. It was shown that for such amino acids as lysine, the amount of sulphurous (methionine + cystine) and threonine amino acid score of combined flour systems increased by 0.7–2 times compared to that of wheat flour. The ratio of soybean, linseed and sunflower meal in the composition of the improved amino acid composition in percentage terms was obtained: 44:25:31. Mathematically calculated the content and rate of essential amino acids in systems, which in their composition contain 90–80% wheat flour and 10–20% composition of oilseed meal. The results of studies of such systems showed that the moisture index is almost the same, and the acidity index is slightly higher than the index (4.68 versus 3.03 degrees) for premium wheat flour. Trial baking of bread was carried out, it’s organoleptic, and physico-chemical parameters were determined in comparison with bread based on premium wheat flour. In a bread sample based on combined flour systems, the moisture content is 39.34%; porosity – 77.15%; acidity – 1.83 degrees. The characteristics of the developed systems make it easy to introduce it into the technological process of existing enterprises for the production of bakery products.
AUTHENTIC CHEESES: MICROBIOLOGY, STARTERS, AND TECHNOLOGICAL ASPECTS OF PRODUCTION
Authors: Danylenko S. , Bondarchuk V. , Khablenko A. , Lukianets A. , Kozlovska G. , Kopylova K.
Published: October 2023

The work is dedicated to the varieties, microbiological peculiarities and technological aspects of production of certain types of authentic cheeses. The purpose of work is to determine the microbiological peculiarities of authentic cheeses, to analyze their varieties and microbiota, to define the biotechnological peculiarities of production of certain types of authentic cheeses. Monographic, constructive, causal analysis and logical generalization methods were used.  Cheese is the most popular food product in the world; there are 5,000 varieties of cheese. Although standard cheeses produced on large-scale productions are the most popular and widespread, authentic cheeses are also popular due to their unique organoleptic properties. Many factors influence the unique characteristics of authentic cheeses, the main of which are the quality of milk, its microbiological and chemical composition, and the technological methods used in cheese-making. All authentic cheeses are characterized by the presence of lactic acid bacteria, but the use of untreated milk sometimes leads to the presence of foodborne pathogens in the final product. Certain authentic cheeses have a complex microbiota, which complicates their production and the creation of starter cultures. However, for many cheeses, especially those like feta, there are now technological approaches to production, and most research is aimed at achieving an authentic taste and improving the organoleptic properties of the final product. Analysis of the quantitative and qualitative composition of the fermenting microbiota and the technological features of different types of traditional cheeses makes it possible to determine the composition of new fermenting compositions that are inherent to a particular product and to choose ways to increase the efficiency of cheese production.
EXPERTISE OF PYRAMID TEA BAGS BY OPTICAL MICROSCOPY AND FTIR-SPECTROSCOPY METHODS. MICROPLASTICS FORMATION IN BREWED TEA
Authors: Malynka O. , Malynka Y. , Petrik K.
Published: October 2023

Eight brands of pyramid tea bags on the Ukrainian market were studied: Sun Gardens (1), Lovare (2), Curtis for Mc Donalds (3), Curtis (4), Lipton (5), Premiya (6), Sonnet (7) and Loyd (8). Using FTIR spectroscopy, it was found that the pyramids of the bags are made of thermoplastic polymers polyethylene terephthalate (samples 1-7) and polylactic acid (sample 8). The threads attached to the pyramids are made of thermoplastic polymers polypropylene (samples 1,2,4-7), polyethylene terephthalate (sample 4) and polylactic acid (sample 8). The specific optical rotation of polylactic acid [α]D25 is about -150° (c=1, CHCl3), which refers to poly(L-lactic acid). Using optical microscopy, it was established that the structure of the pyramids are divided into those made of plain woven fabrics (samples 1-3) and heat-bonded nonwoven fabrics (samples 4-8). The tea bags (samples 1-3) exhibit a well patterned net structure (mesh) with the pores perceived to be uniform and regular. The tea bags made of nonwoven materials have an irregular network consisting of compact and random arrangement of fibers. The fibers are pleated randomly, generating irregular pores. Nonwoven fabrics are made from fibers with a diameter of 12-18 µm, woven fabrics are made from fibers with a diameter of 48-54 µm. The area density of nonwoven fabrics is 18.5-20.3 g/m2, the area density of woven fabrics is 22.0-22.7 g/m2. The threads are made by twisting several single-twisted yarns. The structure of threads are a cabled yarn from three 2-ply yarns (samples 1,8), 4-ply yarn (samples 2-4,6,7) and 4-ply multyfilament yarn (samples 5). The final twist of the plied yarn/cord is S-twist. The primary structural element of threads in the case of samples 1-4, 6-8 are staple fibers, of sample 5 are multyfilament fibers. Each empty pyramids and thread was steeped at 95oC for 5 min in 10 mL of water. It has been established that the shape of microplastic particles formed in beverages during tea brewing is determined by the primary structure of tea bags. Both pyramids and threads release irregularly shaped microplastic particles.
The effects of some essential oils on the life table parameters of green peach aphid Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae)
Authors: KAYAHAN Ali
Published: October 2023

In this study, essential oils (EOs) of Citrus limon (L.), Citrus sinensis (L.) (Sapindales: Rutaceae), Allium sativum (L.) (Asparagales: Amaryllidaceae) and Brassica nigra (L.) (Brassicales: Brassicaceae) were evaluated for their insecticidal effects on the green peach aphid Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae). The lethal and sublethal effects of these EOs on M. persicae were studied under laboratory conditions. This study was conducted at Yozgat Bozok University, Faculty of Agriculture, Department of Plant Protection in 2023. The experiments were evaluated at different concentrations for 24 hours after treatment. The lethal concentrations (LC50, LC90) of the EOs were calculated based on the data obtained. The life table parameters of newly born aphids were studied at sublethal concentrations (LC40, LC30) of EOs, and these parameters were calculated using the Euler-Lotka equation. The results show that the mortality rate increases with growing concentration of essential oils. The lethal concentration (LC50) of essential oils were calculated to be 3.47, 4.37, 4.51, and 5.16 µL/L, respectively. The sublethal concentrations (LC40, LC30) of essential oils caused an increase in adult longevity, a decrease in fecundity of surviving aphids and intrinsic rate of increase. From the data obtained, the EOs of C. limon and C. sinensis were more effective than other EOs in the study. It was found that other essential oils (A. sativum and B. nigra) may also be effective against M. persicae, even if their effect is low.
Spinal anesthesia in elective lumbar spinal surgery
Authors: Hernandez Nicholas S. , Begashaw Benayas , Riesenburger Ron I. , Kryzanski James T. , Liu Penny
Published: October 2023

Spinal anesthesia (SA) is gaining recognition as a safe and efficacious regional alternative to general anesthesia for elective lumbar surgery. However, unfamiliarity with management issues related to its use has limited the adoption of awake spine surgery, despite its benefits. Few centers in the United States routinely offer SA for elective lumbar surgery, and a comprehensive workflow to standardize SA for lumbar surgery is lacking. In this article, we examine recent literature on the use of SA in lumbar surgery, review the experience of our institution with SA in lumbar surgery, and provide a cohesive outline to streamline the implementation of SA from the perspective of the anesthesiologist. We review the critical features of SA in contemporary lumbar surgery, including selection of patients, methods of SA, intraoperative sedation, and management of several important technical considerations. We aimed to flatten the learning curve to improve the availability and accessibility of the technique for eligible patients.
Severe pulmonary edema occurred during endobronchial ultrasound under monitored anesthesia care - A case report -
Authors: Choi Hwan Yong , Kang Hyung Koo , Heo Min Hee , Lee Sang Il , Kim Ji Yeon , Kim Kyung-Tae , Park Jang Su , Choe Won Joo , Kim Kyung Woo , Kim Jun Hyun
Published: October 2023

Background: Endobronchial ultrasound (EBUS) is widely used to diagnose lung cancer. Monitored anesthesia care (MAC) can enhance patient comfort and procedural conditions during EBUS. EBUS under MAC is usually safe but can lead to various complications.Case: A 34-year-old man who had increased sputum for two months showed an enlarged paratracheal lymph node and planned for lymph node biopsy by EBUS. During EBUS under MAC, an unexpected oxygen saturation decline required intervention. After intubation, copious frothy fluid was suctioned from the bronchi, and oxygenation was recovered. A narrowed trachea and the EBUS bronchoscope might have resulted in upper airway obstruction, and suction performed under these conditions might have caused pulmonary edema. The patient received non-invasive ventilation and high-flow nasal cannula and recovered without complications. Conclusions: When there is an expected risk of upper airway obstruction during EBUS, careful preoperative evaluation and preparation are essential to prevent negative pressure pulmonary edema.
Новые институциальные формы социального обслуживания: векторы развития
Authors: Старшинова Алевтина
Published: October 2023

Негосударственные социально-­сервисные организации относятся к новым институциальным формам социального обслуживания. Их становление поддерживается и регулируется государством как институтом, ответственным за сферу общественного благосостояния. В статье рассмотрены государственные стратегии развития новых организаций – нормативно-­правовое закрепление статуса новых исполнителей социальных услуг, вторичная институциализация, социальное инвестирование и госу­дарственно-­частное партнерство (ГЧП), а также стратегии негосударственных организаций, складывающихся за счет гибридных форм, интеграции с другими НКО и социальными государственными учреждениями, инкорпорации в жилищные комплексы городской среды, при­менения инновационных / цифровых технологий социального обслуживания граждан. При этом каждая стратегия имеет свои преимущества и риски. Наше исследование показывает, что большинство региональных НКО ориентированы на финансовую и иную помощь государства. Немно­гочисленные, но более крупные и ресурсно-­обеспеченные организации во многом представляют собой результат гибридного развития и, как правило, первоначально создавались как коммерческие предприятия. Приобретая статус НКО при вхождении в сферу социальных услуг и получая доступ к бюджетному финансированию, такие организации продолжают заниматься предпринимательством для сохранения финансовой устойчивости, наращивая конкурентные преимущества. Направленность некоммерческих организаций на выполнение социальной миссии и одновременно ориентация некоторых из них на конкурентные отношения, выступающих в качестве игроков рынка социальных услуг, образуют два основных вектора развития новых участников производства общественных благ. Рассмотренный в статье кейс социально сервисной организации, инкорпорированной в жилой комплекс, характеризуется клиент-­ориен­тированностью, сочетающей черты гибридности и интегрированности, представляет перспективное направление развития негосударственных организаций социального обслуживания, реализация которого возможна в рамках государственно-­частного партнерства. Исследование проведено с помощью качественных методов в форме интервью, состоявшихся в 2022 г., с представителями НКО, ресурсных центров, государственного учреждения. Концепции совместного производства общественных благ, социального партнерства и межсекторного взаимодействия составили теоретическую основу проведенного исследования.
Актуальные проблемы формирования практик долговременного ухода за пожилыми людьми с деменцией
Authors: Мишеничев Константин , Бородкина Ольга
Published: October 2023

Социально-­демографические процессы, связанные с ростом численности пожилых и людей с деменцией, требуют формирования новых подходов и внедрение иных практик социального обслуживания. Одной из наиболее востребованных практик ухода за пожилыми является система долговременного ухода (СДУ). За последние годы сделаны значительные шаги по улучшению инфраструктуры ухода за пожилыми людьми, в том числе создание правовой базы, развитие некоммерческого сектора и социального предпринимательства. В статье представлены результаты исследования развития системы долговременного ухода за пожилыми с деменцией. Основу эмпирического базы составили данные экспертных интервью (N=33), глубинных интервью с родственниками (N=20) и трех фокус-­групп с сотрудниками социальных служб. В ходе интервью и фокус-­групп обсуждались различные аспекты ухода за людьми с деменцией, в том числе как пожилые люди с деменцией становятся клиентами служб ухода; какие услуги они получают, какие формы ухода являются наиболее распространенными. Результаты исследования выявили трудности с оценкой нуждаемости пожилых с деменцией в уходе, связанные в том числе с организацией процесса оценки и поведенческими особенностями пожилых с деменцией. Одной из наиболее распространенных форм ухода за пожилыми с деменцией остается родственный уход, при этом в СДУ предусматриваются возможности по снижению нагрузки на родственников пожилых с деменцией. В настоящее время активно развивается уход в полустационарных учреждениях, однако им присущи проблемы недостаточного количества персонала для обеспечения безопасности пожилых с деменцией. В заключении подчеркивается, что в настоящее время наблюдается смещение фокуса социальной политики на нуждаемость различных групп пожилых, что сопровождается переходом к политике социального инвестирования. В сфере помощи людям с деменцией, помимо расширения сети специализированных стационарных и нестационарных учреждений, наблюдается развитие программ психологической помощи для людей с деменцией и лиц, осуществляющих уход, а также программ профессионального обучения в области гериатрической психиатрии.
УГОЛОВНО-ПРАВОВОЕ ОБЕСПЕЧЕНИЕ ИНФОРМАЦИОННОЙ БЕЗОПАСНОСТИ УМНОГО ГОРОДА КАК ОБЪЕКТА КИИ
Authors: ЖАРОВА Анна Константиновна
Published: October 2023

Нарушение функционирования экосистемы умного города может привести к значительным негативным последствиям, например к остановке жизни города или всех промышленных предприятий. Информационные системы умного города являются весьма привлекательной целью для злоумышленников и все чаще подвергаются различным компьютерным атакам. Преступления против устойчивости функционирования умного города как объекта критической информационной инфраструктуры (КИИ) наносят существенный вред интересам государства, горожан и умного города как КИИ. В настоящее время этой проблеме не уделяется должного внимания, несмотря на формирование «института ответственности за преступления против информационной безопасности КИИ и информации, обрабатываемой в КИИ». В статье проведен криминологический анализ преступности в сфере компьютерной информации за период с 2017-го по 2022 г. Представлена статистика компьютерных атак на умный город за 2021 г. и первую половину 2022-го и статистика привлеченных к ответственности лиц за совершение компьютерных атак. Проанализированы негативные социальные явления, связанные с преступлениями против безопасности и устойчивости функционирования умного города как объекта КИИ. Анализ статистики привлечения к ответственности лиц за совершенные преступления, предусмотренные ст. 274.1 УК РФ, позволяет заключить, что наибольшее число преступлений связанных с причинением вреда КИИ РФ, совершаются группой лиц по предварительному сговору, или организованной группой, или лицом с использованием своего служебного положения (ч. 4 ст. 274.1 УК РФ). Привлечение к ответственности по ч. 5 ст. 274.1 УК РФ не осуществлялось в 2021 г. и в первой половине 2022 г., из чего можно сделать вывод, что, несмотря на сложную ситуацию в мире, атаки на КИИ РФ не приводили к тяжким последствиям.
Strategies for Structuring Health Systems Science Curriculum in the Korean Medical Education: A Study Based on an Analysis of the Domestic Status of Health Systems Science Education and Case Studies of US Medical Schools
Authors: Chae Yoo Mi , Lee Young Mee , Shim Sun Hee
Published: October 2023

Health systems science (HSS) is recognized as the third pillar of medical education. alongside basic and clinical sciences. Today’s physicians must also be systems thinkers who are able to discern how social, economic, environmental, and technological forces influence clinical decision-making. This study aimed to propose strategies for structuring an HSS curriculum that is tailored to the Korean healthcare and medical education context. First, the authors of this study conducted a survey to identify the present curricular contents of HSS related education at Korean medical schools. Second, a needs assessment was performed to determine the necessity of HSS competencies, as well as the prerequisites for the seamless integration of HSS into the existing curriculum. Third, literature reviews on HSS education at 14 US medical schools and expert consultations was conducted. We would like to propose a set of strategic approaches, classified into two levels: comprehensive and partial restructuring of the current medical curriculum to incorporate HSS. The partial restructuring approach entails a gradual, incremental incorporation of HSS content, while maintaining the current curricular structure. In contrast, a complete overhaul of the curriculum may be ideal to build HSS as the third pillar of medical education, but its feasibility remains relatively limited. The partial reorganization approach, however, has the advantage of being highly feasible. Collaborative efforts between professors and students are imperative to collectively devise effective methods for the seamless integration of HSS into the existing curriculum.
Development and Implementation of Health Systems Science Education in the Clinical Learning Environment
Authors: Na Sang-Hoon
Published: October 2023

Health systems science is a new medical educational field added to the traditional medical education curricula of basic and clinical sciences. Health systems science emphasizes a more comprehensive approach utilizing systems thinking to care for patients, including interactions between multiple healthcare systems. In this review, I explore how health systems science education can be applied when medical instructors teach students in clinical clerkships through representative case studies. This study first looks at examples of health systems science education in clinical clerkship in the United States and suggests how to develop the curriculum of health systems science for clinical learning environments in Korea by combining Kotter’s 8-step change management model and Kern’s 6-step curriculum development model. Finally, based on practical examples from actual clinical practice education situations, suggestions are made regarding how to develop the entire educational program of a medical school from the stage of applying health systems science at the individual level to clinical practice education.
Fulfilling Right to Education for Rohingya Refugee Children in Indonesia
Authors: Rumiartha I Nyoman Prabu Buana , Jayantiari I Gusti Agung Mas Rwa
Published: October 2023

The results of data collection conducted by the United Nations for Refugee Affairs (UNHCR) revealed that out of a total of 1,001 Rohingya ethnic refugees from Myanmar scattered in several refugee camps in Aceh, Indonesia, there were 374 child refugees, of whom were children without pa the principle of universality of human rights states that all humans have the same rights without discrimination, including the granting of the right to education to children of asylum seekers in transit countries. Furthermore, for Rohingya refugees who are already in Indonesia, they are given humanitarian protection, including fulfilling the right to education for Rohingya refugee children, even though Indonesia is not yet a state party to the 1951 convention on refugee status and the 1967 protocol, and does not yet have a system for determining refugee status. The research results show, the Fulfilling Right to Education for Rohingya Refugee Children in Indonesia, based on Law no. 39 of 1999 concerning Human Rights which has standards from the Universal Declaration of Human Rights, while for the protection of refugee children it is confirmed by Law No. 35 of 2014 concerning Child Protection which is the signing and ratification of Covention on the Right of the Child and Presidential Regulation No. 125 of 2016 concerning the Handling of Refugees from Abroad which specifically regulates refugees, ratifying the Convention on the Rights of the Child into Decisions President Number 26 of 1990, then Indonesia has directly agreed to the entire contents of the convention in all actions against children in Indonesia such as the state's obligation to protect children who are within its jurisdiction. The provisions of Government Regulation no. 78 of 2021 concerning Special Protection for Children, in Article 6. Indonesia Ministry of Education and Culture Circular Letter No. 752553/A.A4/HK/2019 concerning Fulfillment of the Right to Education for Children of Foreign Refugees, has opened the way for school-age children of foreign refugees to pursue formal education in educational institutions. The policy of the Indonesian government to fulfill the right to education for the children of overseas refugees should be appreciated. This is because Indonesia has not ratified the 1951 Convention on the Status of Refugees.
Improved precast reinforced concrete crossbar of reduced height. Results of full-scale loading tests
Authors: Shepelev. Alexandr P. , Ibatullin Rustam R. , Pischulev Alexandr A.
Published: October 2023

The object of the study is an improved design of a reinforced concrete floor crossbar as part of a prefabricated frame of a residential building. The crossbar has a reduced height with undercuts in the support zones, which in combination with modified prefabricated multi-hollow plates allows you to perform the lower surface of the overlap without protruding ribs. This solution allows you to use precast reinforced concrete with all its advantages and compete with monolithic reinforced concrete girderless frames. To ensure the strength of inclined sections to the action of transverse force and bending moment, cage using rigid inserts made of sheet steel are used as transverse reinforcement. The results of the tests showed that the developed crossbar meets the stated requirements for both the first and the second group of limit states (strength, stiffness, crack resistance). Transverse reinforcement in the form of cages with rigid inserts made of sheet steel provides the required bearing capacity of inclined sections. The test confirmed the reliable joint work of concrete and rigid inserts from the beginning of loading to the ultimate state of strength.
Outstanding soviet architect Ivan Nikolaevich Dubov: unknown pages of life and work (1904–1975)
Authors: Saprykina Natalya S.
Published: October 2023

The article is devoted to the outstanding architect of the Soviet era in Ivanovo and Yaroslavl, many of whose buildings in these cities are now monuments of architecture, but there is still no information about the life and list of works of I.N. Dubov. For the first time in a comprehensive chronological sequence of examines and evaluates the life and work of the architect, reveals the specificity of his work, analyzes the creative handwriting, reveals the origins of professional success. The work cites all the known and identified to date works of the architect-artist, introducing new scientific information on Soviet architecture.
Issues of architectural and urban organization of university campuses of the Ural federal district
Authors: Popov Alexey V. , Tutyshkin Evgeniy Yu.
Published: October 2023

Campus of a higher educational institution is a multifunctional complex of buildings designed to accommodate university departments connected by a system of special public spaces that form a unified environment for higher education, scientific research, as well as a wide range of related functions in the "worklife-rest" system of all levels for participants in these processes. The purpose of the research work is to develop the existing campuses of higher educational institutions. The object of the study is university campuses. The subject of the study is the features of the architectural and urban planning organization of university campuses. According to the type of architectural and urban planning placement of university campuses in the settlement structure, three types are defined: compact (local), multipart (dissected) and dispersed (dispersed). Typology features are formulated on examples of universities of the Ural Federal District. It is determined that in the conditions of the region under consideration, the most rational organization of campuses is a compact (local) and multipart (dissected) type. It is revealed that the existing architectural environment does not fully meet the requirements for modern universities. In this regard, proposals for the development of existing university campuses are presented, taking into account aspects of the transformation of spaces, interaction with the settlement and integration of the functions of science, education and production.
Retrospective analysis of the development of municipal complex territories in Orenburg
Authors: Bezborodova Olesja N. , Lekareva Nina Af. , Mubarakshina Madena M.
Published: October 2023

The article sets the task of considering the development of the environment of the communal complex in the city of Orenburg. The concepts of "communal complex" and "communal services" are revealed, moving on to the definition of "the active environment of the communal complex". The results of a retrospective analysis are presented in a summary table, which allows you to visually track the development of the environment of the communal complex in the structure of the territories of the city of Orenburg. As a result of the study, a balance was revealed between the areas of the city (in percentage terms), the industrial complex and the communal complex. A brief installation for the modernization of the communal complex is given.
The effect of obesity on oxidative stress parameters in pregnant women
Authors: KOCAMAZ Derya , ATLI Gülizar , MENZİLETOĞLU YILDIZ Şule , ARLIER Sefa , GÜVENÇ Birol
Published: October 2023

Objective: In recent years, there has been a growing public concern about obesity, since it is known to reduce fertility in women and increase the duration of conception. Maternal obesity is also related to adverse pregnancy outcomes affected by placental malfunction. Therefore, in this study, we aimed to compare levels of oxidative stress between obese women and women of normal weight in the second trimester.

Method: We assessed lipid peroxidation by measuring the thiobarbituric acid reactive species (TBARS), as well as the antioxidant defense system by measuring the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) enzymes in 50 obese women (body mass index, BMI:36.60±4.95) and 51 women of normal weight (BMI:24.51±3.47).

Results: Increased lipid peroxidation and SOD enzyme activity were determined in obese pregnant women when compared to women of normal weight. Also, we found a significantly positive correlation (r:0.286, p:0.0435) between BMI and TBARS level as well as a significantly negative correlation (r: -0.421, p:0.002) between TBARS level and SOD enzyme activity. No significant difference was observed between the two groups in CAT and GPx enzymes activities.

Conclusion: Although increased SOD enzyme activity indicates that the antioxidant defense system is activated to deal with increased production of reactive oxygen species, maternal obesity is induced by oxidative stress via increased lipid peroxidation. Hence, maternal-obesity-induced oxidative stress in the second trimester should be followed up by clinicians since it may cause oxidative damage in the placenta during pregnancy.
Environmental, social, governance e desempenho corporativo: uma análise na perspectiva da folga financeira
Authors: Piccinin Yvelise Giacomello , Degenhart Larissa , Lunardi Micheli  Aparecida , Ávila Lucas Veiga , Dos Santos Grodt Jonas Adriel
Published: October 2023

Este trabalho objetivou analisar o efeito moderador da folga financeira na relação entre divulgação ambiental, social e de governança (ESG) e desempenho contábil e de mercado, em empresas brasileiras. A amostra desbalanceada constituiu-se de empresas listadas na Brasil, Bolsa, Balcão (B3), no período de 2016 a 2021. A pesquisa descritiva, documental e quantitativa, operacionalizou-se pela regressão linear por Mínimos Quadrados Ordinários (OLS). Os resultados indicam que as atividades ESG impactam positivamente o desempenho contábil e de mercado em empresas brasileiras. Ademais, organizações com recursos excedentes, impulsionam ações ESG e o desempenho corporativo. Os achados contribuem cientificamente ao indicar que investidores e demais partes interessadas devem analisar com maior cautela, contextos de escassez de recursos e menores índices ESG.
The more intra-firm equity, the higher employee retention: Evidence from the universo of urban firms in Colombia
Authors: Lora Eduardo
Published: October 2023

Fairness and equity considerations may influence workers’ decision to stay or quit their jobs. This paper tests several hypotheses derived from theory on the relation between intra-firm equity and employee retention. It uses administrative data covering the universe of urban firms in Colombia between 2008 and 2016. The average wage of the firm, the intra-firm dispersion of real wage adjustments, and the share of women in the firm are significantly associated with retention rates in the directions predicted by theory. The intra-firm wage gap is directly associated with retention, at odds with theory. The results suggest that equity considerations are important in employees’ decision to stay or quit.
Computer vision syndrome among Al-Rayan Medical Colleges students, Madinah, Saudi Arabia
Authors: Elhassani Abdallah , Aljohani Rahaf , Eisawi Khawlah , Alsaedi Ghadi , Alhilali Maysa , Watad Bushra , Jeha Bana , Alharbi Arwa , Mohammed Nesreen , Alkurdi Abdullah A.
Published: October 2023

Background: Digital devices now become a part of university student’s life, and with prolonged use, they may experience some ocular problems like dryness, headache, eye strain, and pain. These symptoms and others constitute computer vision syndrome (CVS). Our study aimed to assess CVS among Al-Rayan medical college students and to evaluate students’ behaviors related to preventing CVS.
Methods: A cross-sectional, questionnaire-based study was performed among the students of Alrayan Medical College from the period from November to December 2022, with a sample size of 270 cases. Data were collected using (CVS-Q) questionnaire.
Results: Near half of the participants (53.7%) were suffering from CVS. The most reported symptoms included headache (43.3%), tearing (42.9%), burning (39.3%), and blurred vision (35.1%). The most significant measures applied to minimize the impact of electronic devices were putting the digital device at enough distance (p value=0.001) and adjusting the screen brightness of the digital device (p value=0.004).
Conclusions: This study disclosed that CVS is a common problem among medical students. The manifestation of CVS was affected by the frequency and duration of electronic device use.
Convenience and short comings among paediatric cochlear implant candidates
Authors: Hossain Mohammod Delwar , Mahboob Hasan M. , Uddin Mohammad Taslim , Islam Mohammed Sirazul , Ahamed Shamem
Published: October 2023

Background: Cochlear implants have revolutionized the treatment of severe-to-profound sensorineural hearing loss in children. However, the convenience and shortcomings experienced by pediatric cochlear implant candidates in various settings remain understudied. This study aimed to assess the convenience and shortcomings among pediatric cochlear implant candidates in home, school, and other social settings.
Methods: This was a prospective clinical study that was conducted in the Cochlear Implant (CI) Center, Combined Military Hospital (CMH), Dhaka and Chattogram, Bangladesh from July 2015 to December 2022. A total of 200 parents of pediatric cochlear-implanted children were enrolled in this study as the study subjects. A simple random sampling technique was used in sample selection. All data were processed, analyzed, and disseminated by using MS Excel and SPSS version 22.0 program as per necessity.
Results: The study analyzed information collected during the study period, focusing on the convenience and shortcomings reported by the parents of cochlear implant recipients. The findings revealed that the highest level of convenience was reported in some other social settings (82.84%), followed by home (75.67%) and school (64.4%). In contrast, shortcomings were reported primarily in the home environment (63.6%), followed by school (34.6%) and other social settings (31.45%).
Conclusions: In the majority of cochlear implant children, convenience is observed in some other social settings than home or school. In the majority of cochlear implant children, shortcomings are observed in their homes.
Patterns of coagulation profiles observed in different trimesters of pregnancy
Authors: Olufemi-Aworinde Joyce K. , Aworanti Oladapo W. , Ojedokun Samson A. , Akinbola Ibukun O. , Agunbiade-Olu Mobolaji , Akinbola Abraham I.
Published: October 2023

Background: The risk of venous thromboembolic events (VTE) is high during pregnancy due to both physiologic changes in pregnancy and the impact of inherited and acquired thrombophilia. Protein S (PS), Protein C (PC) and Antithrombin III (ATIII) deficiencies have been found in some pregnant women with recurrent miscarriages and sudden maternal death. This study aimed to determine the changes in the level of plasma protein C, protein S and antithrombin III levels, its correlation with normal pregnancy.
Methods: The study was a comparative cross-sectional study conducted among seventy-five normal pregnant women who were selected using a simple random sampling technique with seventy-five age-matched healthy nonpregnant women. Blood samples were collected for analysis of protein C, protein S and antithrombin III using the enzyme-linked immunosorbent assay method. A semi-structured questionnaire was used as the survey instrument and Statistical analysis of data was done using SPSS version 24.
Results: The mean ages of the respondents were 32.6±4.6 and 34.5±6.9 years for the subjects and controls respectively. Natural coagulation inhibitors (NCI) show a gradual decrease across the trimesters of pregnancy. There was a statistical significance in the level of antithrombin III and protein S in the first trimester, p<0.05. When compared with the control of protein S of 4.78±0.65 ng/ml and antithrombin III of 554.16±54.65 ng/mL respectively.
Conclusions: It was demonstrated that there was an accompanying reduction of NCI across the trimester compared with the controls. Antithrombin III and protein S have a significant relationship with the gestation periods. Antithrombin III decreased as pregnancy advanced while protein S decreased significantly from the first trimester to the second trimester and was maintained at that level throughout the pregnancy.