bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic Method for Developing Reference Driving Cycles Appropriate to Electric L-Category Vehicles
Authors: Watling David , Baptista Patrícia , Duarte Gonçalo , Gao Jianbing , Chen Haibo
Published: May 2022

Increasingly, demanding environmental standards reflect the need for improved energy efficiency and reduced externalities in the transportation sector. Reference driving cycles provide standard speed profiles against which future developments and innovations may be tested. In the paper, we develop such profiles for a class of electric L-category vehicles, which are anticipated to play an increasing future role in urban areas. While such driving cycles exist for regular L-category vehicles, these may not be suitable in the case of electric vehicles, due to their power output limitations. We present a methodology for deriving these new driving cycles, developed from empirically deduced power relationships, before demonstrating their application under different assumptions on the terrain and vehicle characteristics. The applications demonstrate the feasibility of the method in developing appropriate driving patterns for alternative real-world contexts. On flat terrain, the adjustments made to cope with the power limitations of L-EV do not introduce significant differences in energy consumption, suggesting that the certification does not require extensive modification. However, when considering road slope, differences of up to 5% in energy use and up to 10% in regenerated energy were observed, showing the importance of the developed method for assessing vehicle performance in real-world driving.
A Flying Restart Strategy for Position Sensorless PMSM Driven by Quasi-Z-Source Inverter
Authors: Cao Yanfei , Xiao Shuxin , Lin Zhichen
Published: May 2022

The accurate estimation of rotor position and speed before flying restart is of great significance to improve the operation reliability of permanent magnet synchronous motor systems. The traditional multizero vector short-circuit method can improve the estimation accuracy of speed and rotor position, but the increased number of short-circuits reduces the electromagnetic torque response speed after the power supply recovers. In order to accurately estimate the initial speed and rotor position before the flying restart and effectively improve the electromagnetic torque response speed, a shoot-through zero vector short-circuit method based on quasi-Z-source inverter (qZSI) is proposed. This method breaks the limitation of regulating DC link voltage under the normal operation of the motor in the conventional methods, and puts forward a new idea of advancing the regulation of the DC link voltage to the stage of abnormal operation before the motor restarts. By designing the insertion mode of the mixed vectors and analyzing the action time of each vector before the flying restart, the accurate estimation of position and speed is realized and, meanwhile, the boost of the qZSI’s DC link voltage is achieved, thus giving the sensorless flying restart method a faster torque response speed for the PMSM system driven by qZSIs.
Substrate Characteristics Fluctuations in Full-Scale Anaerobic Digesters Treating Food Waste at Marginal Organic Loading Rates: A Case Study
Authors: Shin Seung Gu , Park Sang Hyeok , Hwang Seokhwan
Published: May 2022

The design of a full-scale bioprocess is typically based on parameters derived from smaller-scale experiments from a previous study. However, disagreements often occur at up-scaling of waste-to-energy processes due to the fluctuations of the substrate characteristics, etc. Therefore, once a commercial-scale waste digester has been built and operated, it is essential to test if the performance of the process agrees with its design value; during this process, fluctuations might occur in digesters operated at marginal organic loading rates. In this study, triplicate full-scale anaerobic digesters treating food waste were monitored for five months. The digesters, operated at the design feeding ratio, showed increasing volatile fatty acid (VFA) trends (per total alkalinity) due to a 30% higher chemical oxygen demand of the influent, than the design. The organic loading rate was adjusted on a daily basis until a stable performance was observed. Significant shifts of methanogen populations from Methanobacteriales to Methanomicrobiales and Methanosarcinales were observed during the stable operation period.
Metal–Organic Frameworks (MOFs) Containing Adsorbents for Carbon Capture
Authors: Ansone-Bertina Linda , Ozols Viesturs , Arbidans Lauris , Dobkevica Linda , Sarsuns Kristaps , Vanags Edgars , Klavins Maris
Published: May 2022

In this study, new composite materials of montmorillonite, biochar, or aerosil, containing metal–organic frameworks (MOF) were synthesized in situ. Overall, three different MOFs—CuBTC, UTSA-16, and UiO-66-BTEC—were used. Obtained adsorbents were characterized using powder X-ray diffraction, thermogravimetric analysis, nitrogen adsorption porosimetry, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectrophotometry. Additionally, the content of metallic and nonmetallic elements was determined to investigate the crystalline structure, surface morphology, thermal stability of the obtained MOF-composites, etc. Cyclic CO2 adsorption analysis was performed using the thermogravimetric approach, modeling adsorption from flue gasses. In our study, the addition of aerosil to CuBTC (CuBTC-A-15) enhanced the sorbed CO2 amount by 90.2% and the addition of biochar (CuBTC-BC-5) increased adsorbed the CO2 amount by 75.5% in comparison to pristine CuBTC obtained in this study. Moreover, the addition of montmorillonite (CuBTC-Mt-15) increased the adsorbed amount of CO2 by 27%. CuBTC-A-15 and CuBTC-BC-5 are considered to be the most perspective adsorbents, capturing 3.7 mmol/g CO2 and showing good stability after 20 adsorption-desorption cycles.
Advances in Automated Driving Systems
Authors: Eichberger Arno , Szalay Zsolt , Fellendorf Martin , Liu Henry
Published: May 2022

Electrification, automation of vehicle control, digitalization and new mobility are the mega trends in automotive engineering and they are strongly connected to each other [...]
The Thermochemical Conversion of Forestry Residues from Silver Fir (Abies alba Mill.) by Torrefaction and Pyrolysis
Authors: Butnaru Elena , Brebu Mihai
Published: May 2022

Forestry residue is a renewable energy biomass whose valorization has increased due to the interest in replacing exhaustible and environmentally unfriendly fossil resources. Needles, cones and bark from silver fir were thermally processed by separated and combined torrefaction (250 °C) and pyrolysis (550 °C). The torrefaction removed the humidity and extractives and degraded the hemicelluloses, significantly decreasing the oxygen content to ~11 wt% and increasing the carbon content to ~80 wt%, while enhancing the calorific value of the solids (~32 MJ/kg). The pyrolysis produced solid materials with high amounts of fixed carbon (~60–70 wt%) and high heating values, of ~29 MJ/kg. The combined torrefaction + pyrolysis increased the energy yield of the process and decreased the O/C and H/C atomic ratios to about 0.1 and 0.5, respectively, which is close to those of coals. It also led to condensable products with more homogeneously distributed compounds, regardless of the initial biomass type. More than 110 chemical compounds were confirmed in the condensable products, in amounts that depended on the type of starting material and on the thermal treatment. These included the following: terpenes, from extractives; furans, acids and linear ketones, from hemicelluloses; cyclic ketones and saccharides, from cellulose; and aromatic hydrocarbons and phenol derivatives, from lignin. Clear distinctions between the thermal procedures and the sample origins were evidenced by an exploratory data analysis (PCA), which suggested the presence of different types of lignin in the three starting materials.
Evaluation of the Performance Degradation of a Metal Hydride Tank in a Real Fuel Cell Electric Vehicle
Authors: Suárez Santiago Hernán , Chabane Djafar , N’Diaye Abdoul , Ait-Amirat Youcef , Elkedim Omar , Djerdir Abdesslem
Published: May 2022

In a fuel cell electric vehicle (FCEV) powered by a metal hydride tank, the performance of the tank is an indicator of the overall health status, which is used to predict its behaviour and make appropriate energy management decisions. The aim of this paper is to investigate how to evaluate the effects of charge/discharge cycles on the performance of a commercial automotive metal hydride hydrogen storage system applied to a real FCEV. For this purpose, a mathematical model is proposed based on uncertain physical parameters that are identified using the stochastic particle swarm optimisation (PSO) algorithm combined with experimental measurements. The variation of these parameters allows an assessment of the degradation level of the tank’s performance on both the quantitative and qualitative aspects. Simulated results derived from the proposed model and experimental measurements were in good agreement, with a maximum relative error of less than 2%. The validated model was used to establish the correlations between the observed degradations in a hydride tank recovered from a real FCEV. The results obtained show that it is possible to predict tank degradations by developing laws of variation of these parameters as a function of the real conditions of the use of the FCEV (number of charging/discharging cycles, pressures, mass flow rates, temperatures).
Evaluation of the CO2 Storage Capacity in Sandstone Formations from the Southeast Mesohellenic trough (Greece)
Authors: Christopoulou Marina A. , Koutsovitis Petros , Kostoglou Nikolaos , Paraskevopoulou Chrysothemis , Sideridis Alkiviadis , Petrounias Petros , Rogkala Aikaterini , Stock Sebastian , Koukouzas Nikolaos
Published: May 2022

This study investigates the capability of the Southeast Mesohellenic Trough (SE MHT) sandstone formations to serve as a potential reservoir for CO2 storage in response to the emerging climate change issues by promoting environmentally friendly mineral sequestration applications. Sandstone samples, for the first time, were evaluated for their petrographic characteristics, mineral chemistry, geochemical properties, as well as their petrophysical and gas adsorption properties through tests. The sandstones were tested and classified into distinct groups. The most promising site to be considered for pilot CO2 storage testing is the Pentalofos Formation locality since its sandstones display specific mineral phases with the proper modal composition to conceivably react with injected CO2, leading to the development of newly formed and stable secondary mineral phases. The gas adsorption results are also more encouraging for sandstones from this sedimentary formation. All the measured UCS (uniaxial compressive strength), Ei (bending stiffness), and ν (Poisson’s ratio) results are above those dictated by international standards to perform CO2 storage practices safely. Furthermore, the specified targeted locality from the Pentalofos Formation holds the geological advantage of being overlaid by an impermeable cap-rock formation, making it suitable for deploying CO2 mineralization practices. The demarcated area could permanently store a calculated amount of ~50 × 105 tons of CO2 within the geological reservoir by reacting with the specified mineral phases, as specified through the proposed petrographic PrP index (potential reactive phases).
A Multi-Criteria Evaluation of Applications Supporting Public Transport Users
Authors: Solecka Katarzyna , Kiciński Marcin
Published: May 2022

Reducing the energy consumption of transport in urban areas is possible if appropriate measures are taken to make public transport more attractive. These include all kinds of journey planners that are part of the passenger information system. Various applications available on the market allow passengers to evaluate their usability. This paper presents and compares nine of the most popular journey planners available to iOS and Android users travelling in Krakow. The comparison took into account all the information obtained from the surveys. In addition, using a multi-criteria approach, the final ranking of the set of journey planners was developed. The assessment was made on the basis of a set of nine criteria indicated by travellers as the most important ones. The obtained results showed disproportions in the functionality of particular solutions. They also indicated the apps that are most frequently and willingly used by local (urban city/agglomeration) travellers.
Hydrochemical Characterization of Groundwaters’ Fluid Flow through the Upper Mesozoic Carbonate Geothermal Reservoirs in the Geneva Basin: An Evolution more than 15,000 Years Long
Authors: Guglielmetti Luca , Heidinger Michael , Eichinger Florian , Moscariello Andrea
Published: May 2022

Groundwaters circulating in Upper Mesozoic carbonates are of great interest for geothermal heat production and storage applications in the Geneva area. This study aims at providing new insights and proposing new interpretations about the mineral-water reactions and the fluid-flow paths mechanisms across the Geneva Basin (GB). Data from previous studies are combined and improved by new ones collected from cold and hot springs and geothermal exploration wells in 2018 and 2020 in the framework of the GEothermies program and HEATSTORE project. Major ions, trace elements, and the isotopes of Oxygen, Hydrogen, Sulfur, Strontium, and Carbo have been analysed and the results show that the sampled waters have a meteoric origin, the carbonate aquifers act as preferential host rocks for geothermal waters, and partial contribution from the Cenozoic sediments can be observed in some samples. The Jura Mountains and the Saleve Ridge are the main catchment areas and an evolution from a pure Ca-HCO3 footprint for the cold springs, to a Na > Ca-HCO3 and a Na-Cl composutions, is observed at the two geothermal wells. The residence time is in the order of a few years for the cold springs and reaches up to 15–20,000 years for the deep wells.
Khosrow II (590–628 CE)
Authors: Motamedmanesh Mahdi , Royan Samira
Published: May 2022

Khosrow II (r. 590–628 CE) was the last great Sasanian king who took the throne with the help of the Romans and broke with dynastic religious preferences as he became married to a Christian empress. It was under his rule that the Sasanian Empire reached its greatest expansion. From the standpoint of iconographic studies, Khosrow II is among the most influential Persian kings. Although he was literally occupied by rebels and wars within the borders of the Sasanian territories and beyond, Khosrow managed to create a powerful image of himself that emphasized the legitimacy of his monarchy. Indeed, Khosrow Parviz (the Victorious) drew upon royal iconography as a propaganda tool on a wide range of materials such as rock and stucco reliefs, coins, seals, and metal plates. His image (created both visually and verbally) not only revived the traditional iconography of the Persian kings but also evolved it in a way that transcended his time and was passed on to the early Islamic Caliphates after him. Khosrow II imitated and manipulated the traditional royal iconography of his predecessors in order to display his legitimacy, piety, and valor.
Three Adhesive Recipes Based on Magnesium Lignosulfonate, Used to Manufacture Particleboards with Low Formaldehyde Emissions and Good Mechanical Properties
Authors: Balea (Paul) Gabriela , Lunguleasa Aurel , Zeleniuc Octavia , Coşereanu Camelia
Published: May 2022

Adhesives represent an important part in the wood-based composite production, and taking into account their impact on the environment and human health, it is a challenge to find suitable natural adhesives. Starting from the current concerns of finding bio-adhesives, this paper aims to use magnesium lignosulfonate in three adhesive recipes for particleboard manufacturing. First, the adhesive recipes were established, using oxygenated water to oxidize magnesium lignosulfonate (Recipe 1) and adding 3% polymeric diphenylmethane diisocyanate (pMDI) crosslinker (Recipe 2) and a mixture of 2% polymeric diphenylmethane diisocyanate with 15% glucose (Recipe 3). The particleboard manufacturing technology included operations for sorting particles and adhesive recipes, pressing the mats, and testing the mechanical strengths and formaldehyde emissions. The standardized testing methodology for formaldehyde emissions used in the research was the method of gas analysis. Tests to determine the resistance to static bending and internal cohesion for all types of boards and recipes were also conducted. The average values of static bending strengths of 0.1 N/mm2, 0.38 N/mm2, and 0.41 N/mm2 were obtained for the particleboard manufacturing with the three adhesive recipes and were compared with the minimal value of 0.35 N/mm2 required by the European standard in the field. Measuring the formaldehyde emissions, it was found that the three manufacturing recipes fell into emission classes E1 and E0. Recipes 2 and 3 were associated with good mechanical performances of particleboards, situated in the required limits of the European standards. As a main conclusion of the paper, it can be stated that the particleboards made with magnesium-lignosulphonate-based adhesive, with or without crosslinkers, can provide low formaldehyde emissions and also good mechanical strengths when crosslinkers such as pMDI and glucose are added. In this way magnesium lignosulfonate is really proving to be a good bio-adhesive.
A Review on the Production of C4 Platform Chemicals from Biochemical Conversion of Sugar Crop Processing Products and By-Products
Authors: Bruni Gillian O. , Terrell Evan
Published: May 2022

The development and commercialization of sustainable chemicals from agricultural products and by-products is necessary for a circular economy built on renewable natural resources. Among the largest contributors to the final cost of a biomass conversion product is the cost of the initial biomass feedstock, representing a significant challenge in effective biomass utilization. Another major challenge is in identifying the correct products for development, which must be able to satisfy the need for both low-cost, drop-in fossil fuel replacements and novel, high-value fine chemicals (and/or commodity chemicals). Both challenges can be met by utilizing wastes or by-products from biomass processing, which have very limited starting cost, to yield platform chemicals. Specifically, sugar crop processing (e.g., sugarcane, sugar beet) is a mature industry that produces high volumes of by-products with significant potential for valorization. This review focuses specifically on the production of acetoin (3-hydroxybutanone), 2,3-butanediol, and C4 dicarboxylic (succinic, malic, and fumaric) acids with emphasis on biochemical conversion and targeted upgrading of sugar crop products/by-products. These C4 compounds are easily derived from fermentations and can be converted into many different final products, including food, fragrance, and cosmetic additives, as well as sustainable biofuels and other chemicals. State-of-the-art literature pertaining to optimization strategies for microbial conversion of sugar crop byproducts to C4 chemicals (e.g., bagasse, molasses) is reviewed, along with potential routes for upgrading and valorization. Directions and opportunities for future research and industrial biotechnology development are discussed.
Aerodynamic Optimization of a Reduced Scale Model of a Ground Vehicle with a Shape Morphing Technique
Authors: Erdem Ceyhan , Eulalie Yoann , Gilotte Philippe , Harries Stefan , Nayeri Christian N.
Published: May 2022

Aerodynamic performances of ground vehicle continuously improve and a lot of both wind tunnel measurements and Computational Fluid Dynamics (CFD) investigations contribute in the identification of local zones where shape deformation can lead to drag force reduction. Gradient-based optimization with optimal system involving CFD models is one of the powerful methods for shape optimization, but a genetic algorithm applied on the surrogate model can also explore a large design space in a reasonable period of computation time. In this paper, we present an aerodynamic optimization technique using a Kriging model in order to perform CFD simulations of different front air dam geometries situated below the front bumper of a reduced scale road vehicle. A first design-of-experiment (DoE) is undertaken with Large Eddy Simulations (LES), involving height geometric parameters for radial-basis-function of the front air dam, utilizing a Sobol algorithm. Then, a multi-objective-genetic-algorithm (MOGA) is applied on the constituted surrogate model, depending on the geometric parameters of the front air dam, in order to reach a minimum drag coefficient value by considering pressure constraints. Results show that a front air dam can increase the pressure at the rear of the tailgate, especially by slowing the airflow below the underfloor, but an optimum balance is necessary in order to not increase the stagnation pressure on the air dam, leading to the loss of this benefit. The Sobol technique driven by the Kriging model enables the retrieval of optimum airdam shapes found with wind tunnel tests, even with relatively coarse numerical meshes used for CFD simulations.
(Not) Communicating the Environmental Friendliness of Food Packaging to Consumers—An Attribute- and Cue-Based Concept and Its Application
Authors: Dörnyei Krisztina Rita , Bauer Anna-Sophia , Krauter Victoria , Herbes Carsten
Published: May 2022

While consumer understanding of and preferences for environmentally friendly packaging options have been well investigated, little is known about the environmentally friendly packaging attributes communicated to consumers by suppliers via packaging cues. We thus propose a literature-based attribute-cue matrix as a tool for analyzing packaging solutions. Using a 2021 snapshot of the wafer market in nine European countries, we demonstrate the tool’s utility by analyzing the cues found that signal environmentally friendly packaging attributes. While the literature suggests that environmentally friendly packaging is increasingly used by manufacturers, our analysis of 164 wafer packages shows that communication is very limited except for information related to recyclability and disposal. This is frequently communicated via labels (e.g., recycling codes, Green Dot) and structural cues that implicitly signal reduced material use (e.g., less headspace and few packaging levels). Our attribute–cue matrix enables researchers, companies, and policymakers to analyze and improve packaging solutions across countries and product categories. Our finding that environmentally friendly packaging attributes are not being communicated to consumers underscores a pressing need for better communication strategies. Both direct on-pack and implicit communication should help consumers choose more environmentally friendly packaging. Governments are encouraged to apply our tool to identify communication gaps and adopt labeling regulations where needed.
Effects of Different Ionic Polysaccharides in Cooked Lean Pork Batters on Intestinal Health in Mice
Authors: Yu Xia , Zou Li-Fang , Xiong Jia-Hao , Pan Jing-Zhi , Li Pei-Jun , Chen Cong-Gui
Published: May 2022

The effects of cooked lean pork batters with three ionic types of polysaccharides (anionic xanthan-gum/sodium-alginate, neutral curdlan-gum/konjac-gum and cationic chitosan) on the intestinal health of mice were investigated in this study. The results showed that the zeta potential in the sodium-alginate group (−31.35 mV) was higher (p < 0.05) than that in the chitosan group (−26.00 mV), thus promoting the protein hydrolysis in the anionic group because of electrostatic repulsion. The content of total free amino acids in the small intestine in the xanthan-gum and sodium-alginate groups (2754.68 μg and 2733.72 μg, respectively) were higher (p < 0.05) than that in the chitosan group (1949.78 μg), which could decrease the amount of undigested protein entering the colon. The two anionic groups could also increase the abundance of Lactobacillus and the balance of Faecalibaculum and Alistipes in the colon. The content of proinflammatory factor IL−6 of colon tissues in the sodium-alginate group (1.02 ng/mL) was lower (p < 0.05) than that in chitosan, curdlan-gum and konjac-gum groups (1.29, 1.31 and 1.31 ng/mL, respectively). The result of haematoxylin-eosin staining of the colon also revealed that sodium alginate was beneficial for colonic health. The two neutral groups increased the content of faecal short-chain fatty acids in mice. These results demonstrated that anionic polysaccharides have potential for developing functional low-fat meat products.
Amorphophallus konjac: Sensory Profile of This Novel Alternative Flour on Gluten-Free Bread
Authors: Laignier Fernanda , Akutsu Rita de Cássia de Almeida , Lima Bernardo Romão de , Zandonadi Renata Puppin , Raposo António , Saraiva Ariana , Botelho Raquel Braz Assunção
Published: May 2022

This study aimed to evaluate the sensory profile of gluten-free bread with Amorphophallus konjac (AK) flour in different concentrations. This experimental study is divided into three steps: preparation of the gluten-free bread formulations, sensory analysis, and statistical analysis. The addition of Konjac flour in a gluten-free bread formulation was tested in different proportions, 12.5%, 25%, 37.5%, and 50% of the flour content. The checking all-that-apply (CATA) was conducted with 110 panelists; among these, 43 were consumers of gluten-free bread. Sensory analysis was conducted using a 9-point hedonic scale for color, aroma, texture, flavor, appearance, and overall acceptability. The AK flour influenced the sensory characteristics of gluten-free bread. Bread with characteristics closer to those found in bread with gluten was the one with 12.5% of konjac flour for both the acceptability analysis as the attributes raised through a detailed CATA map. The control sample is located next to features like dry appearance, dry texture and grainy, dark color, and salty. Therefore, 12.5% AK gluten-free bread is closer to the characteristics of the control sample, such as light crust color, light crumb color, soft and moist texture, cohesion, and brightness. The bread with the highest percentage of overall consumer acceptance was 12.5% konjac with 93% and 96% acceptance among consumers and non-consumers of gluten-free bread, respectively.
Image Dehazing Based on Local and Non-Local Features
Authors: Jiao Qingliang , Liu Ming , Ning Bu , Zhao Fengfeng , Dong Liquan , Kong Lingqin , Hui Mei , Zhao Yuejin
Published: May 2022

Image dehazing is a traditional task, yet it still presents arduous problems, especially in the removal of haze from the texture and edge information of an image. The state-of-the-art dehazing methods may result in the loss of some visual informative details and a decrease in visual quality. To improve dehazing quality, a novel dehazing model is proposed, based on a fractional derivative and data-driven regularization terms. In this model, the contrast constrained adaptive histogram equalization method is used as the data fidelity item; the fractional derivative is applied to avoid over-enhancement and noise amplification; and the proposed data-driven regularization terms are adopted to extract the local and non-local features of an image. Then, to solve the proposed model, half-quadratic splitting is used. Moreover, a dual-stream network based on Convolutional Neural Network (CNN) and Transformer is introduced to structure the data-driven regularization. Further, to estimate the atmospheric light, an atmospheric light model based on the fractional derivative and the atmospheric veil is proposed. Extensive experiments display the effectiveness of the proposed method, which surpasses the state-of-the-art methods for most synthetic and real-world images, quantitatively and qualitatively.
Hsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis
Authors: Liao Jinrong , Chen Zeng , Luo Xingguan , Su Ying , Huang Tao , Xu Haipeng , Lin Keyu , Zheng Qianlan , Zhang Lurong , Lin Gen , Lin Xiandong
Published: May 2022

Circular RNA (CircRNA) is related to tumor development. Nevertheless, the regulation and function of hsa_circ_0006692 and its interactions with miR-205-5p and CDK19 in the development of non-small-cell lung cancer (NSCLC) were un-explored. The correlations of expression levels of hsa_circ_0006692 in NSCLC specimens and cells with pathological characteristics were studied. The interactions of hsa_circ_0006692 with miR-205-5p and CDK19 were assessed with real-time PCR, RNA-binding protein immunoprecipitation (RIP), luciferase reporter, RNA pull-down, and fluorescence in situ hybridization (FISH). The roles of hsa_circ_0006692 on cell growth, invasion, and migration in vitro and metastasis in vivo were evaluated. Hsa_circ_0006692 was over-expressed in 60 cases of NSCLC specimens and cells, which was positively correlated with TNM stage, tumor size, and invasion of the lung basal layer. The results of the in vitro and in vivo studies revealed that the over-expression of hsa_circ_0006692 facilitated NSCLC cell growth, migration, and invasion, cell cycle arrest at the S phase, and the activation of BCL-2, CCND1, and PCNA. The results of the dual-luciferase reporter assay, RNA immunoprecipitation, and pull-down assays indicated that hsa_circ_0006692 sponged miR-205-5p, which targeted CDK19 and facilitated the malignant behaviors of lung cancer cells. Hsa_circ_0006692 modulated EMT of lung cancer cells via the stimulation of CDH1, CDH2, VIMENTIN, and MMP7. This study revealed that hsa_circ_0006692 promoted NSCLC progression via enhancing cell growth, invasion, and metastasis through sponging mir-205-5p, up-regulating the downstream oncogene CDK19 and modulating EMT of lung cancer cells. The circ-0006692/mir-205-5p/CDK19 axis might serve as a prognosis biomarker and target for drugs aimed against NSCLC.
Direct Effect of Local Cryotherapy on Muscle Stimulation, Pain and Strength in Male Office Workers with Lateral Epicondylitis, Non-Randomized Clinical Trial Study
Authors: Radecka Aleksandra , Lubkowska Anna
Published: May 2022

Background: Local cryotherapy (LC) is one of the physiotherapeutic methods used in the conservative treatment of lateral epicondylitis (LE). The aim of the study was to verify the direct effect of a single LC procedure on the clinical symptoms of lateral epicondylitis enthesopathy (pain, pain free grip, PFG) and its effect on the bioelectrical properties of the wrist extensor muscles at rest, on maximal contraction and isometric contraction during fatigue. Methods: The study group was 28 men (35.4 ± 6.13 years) with confirmed unilateral epicondylitis. The performed procedures included the assessment of pain (visual analogue scale, VAS), PFG and ARMS (root-mean-square amplitude) and mean frequencies (MNF) of the sEMG signal before (T0) and after (T1) LC on the side with enthesopathy (ECRE) and without enthesopathy (ECRN/E). Results: There was an increase in the ARMS values of the signals recorded during rest and MVC from the ECR muscles both with and without enthesopathy (p = 0.0001, p = 0.006), an increased PFG after LC only on the side with LE (p < 0.0001) and decreased pain (p < 0.0001). During isometric fatigue contraction, a higher ARMS on both the ECRE side (p < 0.0001) and the ECRN/E side (p < 0.0001) was observed after LC treatment, and a lower MNF was observed on both the ECRN/E side (p < 0.0001) and the ECRE side (p < 0.0001) after LC. Conclusions: LC reduces the pain and increases PFG and muscle excitation expressed by ARMS and seems to delay muscle fatigue.
Socioeconomic Status and Interest in Genetic Testing in a US-Based Sample
Authors: Dusic EJ , Bowen Deborah J. , Bennett Robin , Cain Kevin C. , Theoryn Tesla , Velasquez Mariebeth , Swisher Elizabeth , Brant Jeannine M. , Shirts Brian , Wang Catharine
Published: May 2022

Cancer is a significant burden, particularly to individuals of low socioeconomic status (SES). Genetic testing can provide information about an individual’s risk of developing cancer and guide future screening and preventative services. However, there are significant financial barriers, particularly for individuals of low SES. This study used the Early Detection of Genetic Risk (EDGE) Study’s patient baseline survey (n = 2329) to evaluate the relationship between socioeconomic status and interest in pursuing hereditary cancer genetic testing. Analysis was completed for two interest outcomes—overall interest in genetic testing and interest in genetic testing if the test were free or low cost. Many demographic and SES variables were predictors for interest in genetic testing, including education, income, and MacArthur Subjective Social Scale (SSS). After controlling for the healthcare system, age, and gender, having a higher education level and a higher household income were associated with greater general interest. Lower SSS was associated with greater interest in genetic testing if the test was free or low cost. If genetic testing is the future of preventative medicine, more work needs to be performed to make this option accessible to low-SES groups and to ensure that those services are used by the most underserved populations.
Fruit Quality Response to Different Abaxial Leafy Supplemental Lighting of Greenhouse-Produced Cherry Tomato (Solanum lycopersicum var. Cerasiforme)
Authors: Jiang Chengyao , Rao Jiahui , Rong Sen , Ding Guotian , Liu Jiaming , Li Yushan , Song Yu
Published: May 2022

Insufficient light supply for canopies is a constant issue during greenhouse production in most areas of Northern China. Applying supplemental lighting to plant canopies is an efficient method of solving this problem. Several studies were conducted to identify the optimal, economically efficient abaxial leafy supplemental lighting mode to produce high-quality greenhouse tomatoes. In this experiment, no supplemental treatment was used as a blank control (CK), while three supplemental lighting modes were used as treatments: T1, continuous supplemental lighting from 8:00–9:00 (at GMT+8, which is 6:00–7:00 local time, before the thermal insulation covers, abbreviated as TIC below, opening), and 20:00–22:00 (after TIC closing) with photosynthetic photon fluxion density (PPFD) of 200 μmol·m−2·s−1; T2, dynamic altered supplemental lighting with PPFD rising from 100 μmol·m−2·s−1 to 200 μmol·m−2·s−1 before TIC opening and falling from 200 μmol·m−2·s−1 to 100 μmol·m−2·s−1 after TIC closing; and T3, intermittent supplemental lighting which was automatically conducted with PPFD of 100 μmol·m−2·s−1 when indoor PPFD below 150 μmol·m−2·s−1 from 8:00–22:00. The results demonstrated that abaxial leafy supplemental lighting treatment could improve both fruit yield and quality. The total yield in the T1 and T2 treatments was higher than in other treatments, though there was no significant difference. Differences in leaf carbon exportation showed the possibility of determining fruit yield from the 3rd leaf under the fruit. The overall appearance, flavor quality, nutrient indicators, and aroma of cherry tomato fruits under T1 and T2 treatments were generally higher than in other treatments. Correlation analysis of fruit yield and quality parameters suggested that they produce relatively high yield and fruit quality. Combined with a cost-performance analysis, dynamic altered supplemental lighting (T2) is more suitable for high-valued greenhouse cherry tomato production.
Siblings and Early Childhood Development: Evidence from a Population-Based Cohort in Preschoolers from Shanghai
Authors: Wu Saishuang , Zhang Donglan , Li Xinyue , Zhao Jin , Sun Xiaoning , Shi Lu , Mao Yuping , Zhang Yunting , Jiang Fan
Published: May 2022

(1) Background: The current study aims to investigate the association between the presence of a sibling and early childhood development (ECD). (2) Methods: Data were obtained from a large-scale population-based cohort in Shanghai. Children were followed from three to six years old. Based on birth order, the sample was divided into four groups: single child, younger child, elder child, and single-elder transfer (transfer from single-child to elder-child). Psychosocial well-being and school readiness were assessed with the total difficulties score from the Strengths and Difficulties Questionnaire (SDQ) and the overall development score from the early Human Capability Index (eHCI), respectively. A multilevel model was conducted to evaluate the main effect of each sibling group and the group × age interaction effect on psychosocial well-being and school readiness. (3) Results: Across all measures, children in the younger child group presented with lower psychosocial problems (β = −0.96, 95% CI: −1.44, −0.48, p < 0.001) and higher school readiness scores (β = 1.56, 95% CI: 0.61, 2.51, p = 0.001). No significant difference, or marginally significant difference, was found between the elder group and the single-child group. Compared to the single-child group, the single-elder transfer group presented with slower development on both psychosocial well-being (Age × Group: β = 0.37, 95% CI: 0.18, 0.56, p < 0.001) and school readiness (Age × Group: β = −0.75, 95% CI: −1.10, −0.40, p < 0.001). The sibling-ECD effects did not differ between children from families of low versus high socioeconomic status. (4) Conclusion: The current study suggested the presence of a sibling was not associated with worse development outcomes in general. Rather, children with an elder sibling are more likely to present with better ECD.
Modeling di (2-ethylhexyl) Phthalate (DEHP) and Its Metabolism in a Body’s Organs and Tissues through Different Intake Pathways into Human Body
Authors: Li Ao , Kang Lingyi , Li Runjie , Wu Sijing , Liu Ke , Wang Xinke
Published: May 2022

Phthalate esters (PAEs) are ubiquitous in indoor environments as plasticizers in indoor products. Residences are often exposed to indoor PAEs in the form of gas, particles, settled dust, and surface phases. To reveal the mechanism behind the accumulation of PAEs in different tissues or organs such as the liver and the lungs when a person exposed to indoor PAEs with different phases, a whole-body physiologically based pharmacokinetic model for PAEs is employed to characterize the dynamic process of phthalates by different intake pathways, including oral digestion, dermal adsorption, and inhalation. Among three different intake pathways, dermal penetration distributed the greatest accumulation of DEHP in most of the organs, while the accumulative concentration through oral ingestion was an order of magnitude lower than the other two doses. Based on the estimated parameters, the variation of di-ethylhexyl phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) concentration in the venous blood, urine, the liver, the thymus, the pancreas, the spleen, the lungs, the brain, the heart, and the kidney for different intake scenarios was simulated. The simulated results showed a different accumulation profile of DEHP and MEHP in different organs and tissues and demonstrated that the different intake pathways will result in different accumulation distributions of DEHP and MEHP in organs and tissues and may lead to different detrimental health outcomes.
Accuracy of Fetal Biacromial Diameter and Derived Ultrasonographic Parameters to Predict Shoulder Dystocia: A Prospective Observational Study
Authors: La Verde Marco , De Franciscis Pasquale , Torre Clelia , Celardo Angela , Grassini Giulia , Papa Rossella , Cianci Stefano , Capristo Carlo , Morlando Maddalena , Riemma Gaetano
Published: May 2022

Background and Objectives: Shoulder dystocia (ShD) is one of most dangerous obstetric complication. The objective of this study was to determine if the ultrasonographic fetal biacromial diameter (BA) and derived parameters could predict ShD in uncomplicated term pregnancies. Materials and Methods: We conducted a prospective observational study in a tertiary care university hospital from March 2021 to February 2022. We included all full-term pregnancies accepted for delivery that received an accurate ultrasonography (USG) scan before delivery. USG biometry and estimated fetal weight (EFW) were collected. Therefore, we evaluated the diameter of the mid-arm, the transverse thoracic diameter (TTD) and the biacromial diameter (BA). BA was estimated using Youssef’s formula: TTD + 2 mid-arm diameters. The primary outcome was the evaluation of BA and its related parameters (BA/biparietal diameter (BPD), BA/head circumference (HC) and BA–BPD in fetuses with ShD versus fetuses without ShD. Diagnostic accuracy for ShD of BA, BA/BPD, BA/HC and BA–BPD was evaluated using receiver operator curve (ROC) analysis. Results: 90 women were included in the analysis, four of these had ShD and required extra maneuvers after head delivery. BA was increased in fetuses with ShD (150.4 cm; 95% CI 133.2 cm to 167.6 cm) compared to no-ShD (133.5 cm; 95% CI 130.1 cm to 137.0 cm; p = 0.04). Significant differences were also found between ShD and no-ShD groups for BA/BPD (1.66 (95% CI 1.46 to 1.86) vs. 1.44 (95% CI 1.41 to 1.48); p = 0.04), BA/HC (0.45 (95% CI 0.40 to 0.49) vs. 0.39 (95% CI 0.38 to 0.40); p = 0.01), BA–BPD (60.0 mm (95% CI 42.4 to 77.6 cm) vs. 41.4 (95% CI 38.2 to 44.6); p = 0.03), respectively. ROC analysis showed an overall good accuracy for ShD, with an AUC of 0.821 (p = 0.001) for BA alone and 0.881 (p = 0.001), 0.857 (p = 0.016) and 0.867 (p = 0.013) for BA/BPD, BA–BPD and BA/HC, respectively. Conclusions: BA alone, as well as BA/BPD, BA/HC and BA–BPD might be useful predictors of ShD in uncomplicated term pregnancies. However, such evidence needs extensive confirmation by means of additional studies with large sample sizes, especially in case of pregnancies at high risk for ShD (i.e., gestational diabetes).
Clinical Use of Aligners Associated with Nuvola® OP System for Transverse Maxillary Deficiency: A Retrospective Study on 100 Patients
Authors: Perrotti Giovanna , Carrafiello Alessandro , Rossi Ornella , Karanxha Lorena , Baccaglione Giulia , Del Fabbro Massimo
Published: May 2022

Introduction: Aligners represent a common treatment for orthodontic patients thanks to their countless advantages including aesthetics, comfort, and oral hygiene maintenance; at the same time, they are associated with a reduced number of visits and a low incidence of complications. Although aligners have undergone considerable improvements over time, to date they have limitations in resolving the most serious malocclusions related to transverse maxillary deficiency. The aim of the present study was to retrospectively evaluate an orthodontic protocol (the Nuvola® OP System) which associates a morpho-functional corrector (to be used for 30 min/day) with the aligner, allowing for the treatment of cases that would be difficult or unpredictable with aligners alone. Methods: Linear measurements were taken on STL files of 100 patients. In 77 patients between 18 and 55 years (mean 28.6 ± 16.2 (standard deviation) years), 3D superimpositions of the maxilla obtained from intraoral scans before and after treatment were performed in order to evaluate the degree of maxillary expansion. The normality of the data distribution was tested. The pre- and post-treatment data were compared using a paired t-test with a 5% significance level. After treatment, a questionnaire was proposed to assess patients’ degree of satisfaction and compliance. Results: A statistically significant difference (p < 0.05) for each distance evaluated was found. The maximum expansion was obtained at the first molar level (2.35 ± 1.64 mm). Of the subjects who completed the questionnaire, 96% were satisfied and 90% were able to perform the protocol without difficulty for the required duration. Conclusions: A significant expansion of the maxillary arch as well as a high degree of patient satisfaction and compliance were observed with the Nuvola® OP System. Further studies are needed in order to clinically evaluate the relative contribution of the aligners and morpho-functional device to the obtained expansion.
Lagged Effects of Exposure to Air Pollutants on the Risk of Pulmonary Tuberculosis in a Highly Polluted Region
Authors: Feng Yuqing , Wei Jing , Hu Maogui , Xu Chengdong , Li Tao , Wang Jinfeng , Chen Wei
Published: May 2022

Background: Although significant correlations have been observed between air pollutants and the development of pulmonary tuberculosis (PTB) in many developed countries, data are scarce for developing and highly polluted regions. Method: A combined Poisson generalized linear regression–distributed lag nonlinear model was used to determine the associations between long-term exposure (2005–2017) to air pollutants and the risk of PTB in the Beijing–Tianjin–Hebei region. Results: The monthly PTB cases exhibited a fluctuating downward trend. For each 10 μg/m3 increase in concentration, the maximum lag-specific risk and cumulative relative risk (RR) were 1.011 (95% confidence interval (CI): 1.0091.012, lag: 3 months) and 1.042 (1.036–1.048, 5 months) for PM2.5, and 1.023 (1.015–1.031, 0 months) and 1.041 (1.026–1.055, 2 months) for NO2. The risk of PTB was negatively correlated with O3 exposure, and the minimum lag-specific risk and cumulative RR were 0.991 (95% CI: 0.987–0.994, lag: 0 months) and 0.974 (0.968–0.981, 4 months), respectively. No age-dependent effects were observed. Conclusions: Our results revealed potential associations between outdoor exposure to PM2.5, NO2, and O3 and the risk of PTB. Further research should explore the corresponding interactions and potential mechanisms.
An Empirical Research on the Behavioral Perceptions of University Students on Their ERASMUS Mobilities Abroad
Authors: Marinescu Nicolae , Madar Anca , Neacsu Nicoleta Andreea , Schiopu Camelia
Published: May 2022

The European Union (EU) labor market needs a better-skilled workforce that can work in any of the Member States. In order to develop the skills and competencies of future competitors in this market, several student mobility programs have been set up in the EU, where they can travel to universities in partner countries to further their studies and enrich their academic performance, culture and knowledge. The best known of these programs is ERASMUS (European Region Action Scheme for the Mobility of University Students). Because Romania also participates in this program in the exchange of university students, the authors wanted, through this study, to highlight the benefits and challenges of participation in the program, to analyze how international mobilities are emotionally perceived by students and what are the behavioral reasons that determine Romanian students to choose a certain university as a study destination abroad. For this purpose, the authors conducted quantitative marketing research among students from the Transilvania University of Brasov who have been abroad with ERASMUS scholarships. The research results show that an important component in choosing a certain university is not the financial expense during the mobility as might have been expected, but rather the initial desire to study abroad. Students also consider the improvement of their academic performance as an equally important reason for embarking on mobility to the social aspect of getting to know other cultures.