bluuebunny/crossref_metadata_2025 huggingface dataset:
Impedance Cardiography and Heart Rate Variability for Long-Term Cardiovascular Outcome Prediction After Myocardial Infarction
Authors: Ablonskytė-Dūdonienė Rūta , Bakšytė Giedrė , Čeponienė Indrė , Kriščiukaitis Algimantas , Drėgūnas Kęstutis , Ereminienė Eglė
Published: April 2018

Background and Objective. The objective of our study was to evaluate the predictive power of a combined assessment of heart rate variability (HRV) and impedance cardiography (ICG) measures in order to better identify the patients at risk of serious adverse events after ST-segment elevation myocardial infarction (STEMI): all-cause or cardiac mortality (primary outcomes) and in-hospital recurrent ischemia, recurrent nonfatal MI, and need for revascularization (secondary outcomes). Material and Methods. A total of 213 study patients underwent 24-hour electrocardiogram (used for HRV analysis) and thoracic bioimpedance monitoring (used for calculation of hemodynamic measures) immediately after admission. The patients were examined on discharge and contacted after 1 and 5 years. Cox regression analysis was used to determine the predictors of selected outcomes. Results. The standard deviation of all normal-to-normal intervals (SDNN) and cardiac power output (CPO) were found to be the significant determinants of 5-year all-cause mortality (SDNN ≤100.42 ms and CPO ≤1.43 W vs. others: hazard ratio [HR], 11.1; 95% CI, 4.48–27.51; P<0.001). The standard deviation of the averages of NN intervals (SDANN) and CPO were the significant predictors of 5-year cardiac mortality (SDANN ≤85.41 ms and CPO ≤1.43 W vs. others: HR, 11.05; 95% CI, 3.75–32.56; P<0.001). None of the ICG measures was significant in predicting any secondary outcome. Conclusions. The patients with both impaired autonomic heart regulation and systolic function demonstrated by decreased heart rate variability and impedance hemodynamic measures were found to be at greater risk of all-cause and cardiac death within a 5-year period after STEMI. An integrated analysis of electrocardiogram and impedance cardiogram helps estimate patient’s risk of adverse outcomes after STEMI.
Tear Nitric Oxide Levels in Behçet’s Disease
Authors: İşcan Yalçın , Yiğit Ulviye , Tuğcu Çakmak Betül , Erdoğan Mehmet , Erdoğan Derya , Öner Veysi , Taş Mehmet , Özyazgan Yılmaz
Published: April 2018

The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet’s disease and to compare it with that in healthy subjects. Material and Methods. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm. Results. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups. Conclusion. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet’s disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases.
Potential Candidate Genes for Alveolar Hypoxia Identified by Transcriptome Network Analysis
Authors: Zhang Bi-li , Xu Rong-liang , Qin Yong-wen , Zheng Xing , Wu Hong , You Xiao-hua , Cao Jiang , Hu Jian-qiang , Zhao Xian-xian
Published: April 2018

Background. Alveolar hypoxia is an important condition related to many disorders such as chronic pulmonary hypertension, pulmonary vasoconstriction, and pulmonary vascular remodeling. The aim of present study was to disclose the biological response and the potential transcriptome networks regulating the hypoxia response in the lungs. Materials and Methods. In this study, the microarray dataset GSE11341 was used to construct a regulatory network and identify the potential genes related to alveolar hypoxia. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) term enrichment analyses were also performed. Results. Hypoxia inducible factor 1 alpha (HIF-1α), peroxisome proliferator-activated receptor gamma (PPARγ), and nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-кB) were to be the hub nodes in the transcriptome network. HIF-1α may regulate potassium voltagegated channel, shaker-related subfamily, member (5KCNA5), solute carrier family 2 (facilitated glucose transporter), member (1SLC2A1), and heme oxygenase (decycling) 1 (HMOX1) expression through the regulation of membrane potential, glucose metabolism, and anti-inflammation pathways. HMOX-1 mediates signaling pathways that relate to NF-кB. CCND1 (cyclin D1) expression could be regulated by PPARγ and HIF-1α via the cell cycle pathway. In addition, new transcriptional factors and target genes, such as phosphofructokinase (PFKL, liver), aldolase A (ALDOA, fructose-bisphosphate), and trefoil factor 3 (intestinal) (TFF3), were also identified. Conclusions. Transcriptome network analysis is a helpful method for the identification of the candidate genes in alveolar hypoxia. The KEGG pathway and GO term analysis are beneficial in the prediction of the underlying molecular mechanism of these identified genes in alveolar hypoxia.
Comparison of Different Anesthetic Regimens in Patients Undergoing Laparoscopic Adjustable Gastric Banding Operations: A Prospective Randomized Trial
Authors: Kontrimavičiūtė Eglė , Šipylaitė Jūratė , Aksionova Diana , Cincilevičiūtė Giedrė , Brimas Gintautas
Published: April 2018

Background and Objective. Obesity is a multisystem disorder, particularly involving the respiratory and cardiovascular systems; therefore, a multidisciplinary approach is required. In spite of widespread performance of weight reduction (bariatric) surgeries, information regarding the anesthetic care of morbidly obese patients is scarce. The aim of this study was to compare the impact of fentanyl and remifentanil on the time of recovery, breathing parameters, and postoperative pain in morbidly obese patients undergoing laparoscopic adjustable gastric banding operations. Material and Methods. In this prospective randomized study, 66 morbidly obese patients (BMI>35 kg/m2), aged between 24 and 70 years, scheduled for a laparoscopic adjustable gastric banding operation were divided into 2 groups based on the opioid used for anesthesia: group 1 whose who received remifentanil; and group 2, fentanyl). The following parameters were recorded: peripheral blood oxygenation (SpO2) while breathing room air at baseline and 5 minutes after preoxygenation (100%); end-tidal carbon dioxide pressure at designated time points during the procedure; time to extubation; SpO2 in the postanesthesia care unit; and pain intensity (using the visual analogue scale); and the presence of nausea and vomiting. Results. The time to extubation was shorter in the remifentanil group, but there was no significant difference in the time to discharge from the postanesthesia care unit. The recovery of respiratory parameters to the baseline values was better and faster in the remifentanil group. The intensity of postoperative pain was similar in both groups (VAS, <3) Conclusions. Remifentanil showed good analgesic properties during laparoscopic gastric banding surgery. Postanesthesia recovery and return of respiratory parameters to the baseline values was faster when remifentanil was used. Postoperative pain and the rate of opioid-induced side effects after analgesia with remifentanil were similar as after anesthesia with a longer acting opioid, fentanyl. Despite the problem widely discussed in literature about remifentanil-induced hyperalgesia, no cases of analgesic overconsumption were registered in our study.
The Effect of Nebulized Dorzolamide/Timolol Fixed Combination Mist versus Drops on Retrobulbar Blood Flow and Intraocular Pressure in Glaucoma Patients
Authors: Janulevičienė Ingrida , Šiaudvytytė Lina , Baršauskaitė Rūta , Dilienė Vaida , Kuzmienė Loreta , Siesky Brent , Harris Alon
Published: April 2018

Objective. The aim of this study was to evaluate intraocular pressure (IOP), retrobulbar blood flow (RBF), and ocular side effects after the application of topical dorzolamide/timolol fixed combination (DTFC) drops vs topical nebulized DTFC mist in patients with primary openangle glaucoma. Material and Methods. A total of 15 POAG patients were enrolled in a prospective study. Retrobulbar blood flow was measured in the ophthalmic (OA) and central retinal (CRA) arteries using color Doppler imaging. DTFC mist or drops were applied to the experimental eye, and it was examined after 15 and 60 minutes. DTFC mist was applied 6 times for 30 seconds using a misting device. Results. DTFC mist significantly increased peak-systolic (PSV) and end-diastolic (EDV) velocities after 15 and 60 minutes in both the arteries (OA: increase of 12.5% and 9.6% in PSV, P=0.01; increase of 25.8% and 23.1% in EDV, P=0.03; CRA: increase of 11.5% and 8.7% in PSV, increase of 32% and 21.6% in EDV, respectively, P<0.05). DTFC drops had a similar effect on PSV and EDV in the CRA after 15 and 60 minutes (increase of 8.1% and 9.6% in PSV; increase of 17.1% and 23% in EDV, respectively, P=0.03), but a significant effect on PSV and EDV in the OA was documented only after 15 minutes (increase of 9% and 21.4%, respectively, P=0.02). DTFC mist reduced the resistance index in the CRA after 15 and 60 minutes (decrease of 8.5% and 10.2%, respectively, P=0.04). Both methodologies showed a significant decrease in IOP after 15 and 60 minutes (P<0.05). All patients complained of ocular irritation after drop application, and 1 patient complained of general weakness after mist treatment. Conclusions. Nebulized DTFC mist significantly reduced IOP and increased blood flow in the OA and the CRA, causing no ocular irritation as compared with traditional DTFC drop methodology.
The Chemical Composition and Metabolic Effects of Attalea phalerata Nut Oil in Hyperlipidemic Rats Induced by a High-Fructose Diet
Authors: Baldivia Débora da Silva , Sanjinez-Argandonã Eliana Janet , Antunes Kátia Ávila , Moraes Izabel Cristina Freitas , Dos Santos Edson Lucas , De Picoli Souza Kely
Published: April 2018

The fatty acids found in nuts are important regulators of the metabolism. These acids are frequently associated with a reduction of serum cholesterol and body fat and a lower risk of developing cardiovascular disease. In this context, the aim of this study was to identify and quantify the nut oil fatty acids from Attalea phalerata and investigate their metabolic effects in rats with hyperlipidemia induced by a diet rich in fructose. Oleic and lauric acids were the major compounds found in the A. phalerata nut oil (APNO). Hyperlipidemic rats treated with APNO showed a reduction in the total serum cholesterol similar to those treated with simvastatin, an increased body temperature by 1 °C, and a reduction in the body weight gain and mesenteric depot of white adipose tissue compared to the hyperlipidemic controls rats. There was an increase in the relative liver weight of rats treated with APNO, without, however, any change in the serum markers of hepatic toxicity. In addition, there was an increase in the moisture and lipid content of the feces of the rats treated with APNO compared to the controls. Together, these results suggest that APNO has potential use in health foods and nutritional supplements to control hypercholesterolemia and obesity.
Modified Fusarium Mycotoxins in Cereals and Their Products—Metabolism, Occurrence, and Toxicity: An Updated Review
Authors: Bryła Marcin , Waśkiewicz Agnieszka , Ksieniewicz-Woźniak Edyta , Szymczyk Krystyna , Jędrzejczak Renata
Published: April 2018

Mycotoxins are secondary fungal metabolites, toxic to humans, animals and plants. Under the influence of various factors, mycotoxins may undergo modifications of their chemical structure. One of the methods of mycotoxin modification is a transformation occurring in plant cells or under the influence of fungal enzymes. This paper reviews the current knowledge on the natural occurrence of the most important trichothecenes and zearalenone in cereals/cereal products, their metabolism, and the potential toxicity of the metabolites. Only very limited data are available for the majority of the identified mycotoxins. Most studies concern biologically modified trichothecenes, mainly deoxynivalenol-3-glucoside, which is less toxic than its parent compound (deoxynivalenol). It is resistant to the digestion processes within the gastrointestinal tract and is not absorbed by the intestinal epithelium; however, it may be hydrolysed to free deoxynivalenol or deepoxy-deoxynivalenol by the intestinal microflora. Only one zearalenone derivative, zearalenone-14-glucoside, has been extensively studied. It appears to be more reactive than deoxynivalenol-3-glucoside. It may be readily hydrolysed to free zearalenone, and the carbonyl group in its molecule may be easily reduced to α/β-zearalenol and/or other unspecified metabolites. Other derivatives of deoxynivalenol and zearalenone are poorly characterised. Moreover, other derivatives such as glycosides of T-2 and HT-2 toxins have only recently been investigated; thus, the data related to their toxicological profile and occurrence are sporadic. The topics described in this study are crucial to ensure food and feed safety, which will be assisted by the provision of widespread access to such studies and obtained results.
Magnetic Properties of Metal–Organic Coordination Networks Based on 3d Transition Metal Atoms
Authors: Blanco-Rey María , Sarasola Ane , Nistor Corneliu , Persichetti Luca , Stamm Christian , Piamonteze Cinthia , Gambardella Pietro , Stepanow Sebastian , Otrokov Mikhail M. , Golovach Vitaly N. , Arnau Andres
Published: April 2018

The magnetic anisotropy and exchange coupling between spins localized at the positions of 3d transition metal atoms forming two-dimensional metal–organic coordination networks (MOCNs) grown on a Au(111) metal surface are studied. In particular, we consider MOCNs made of Ni or Mn metal centers linked by 7,7,8,8-tetracyanoquinodimethane (TCNQ) organic ligands, which form rectangular networks with 1:1 stoichiometry. Based on the analysis of X-ray magnetic circular dichroism (XMCD) data taken at T = 2.5 K, we find that Ni atoms in the Ni–TCNQ MOCNs are coupled ferromagnetically and do not show any significant magnetic anisotropy, while Mn atoms in the Mn–TCNQ MOCNs are coupled antiferromagnetically and do show a weak magnetic anisotropy with in-plane magnetization. We explain these observations using both a model Hamiltonian based on mean-field Weiss theory and density functional theory calculations that include spin–orbit coupling. Our main conclusion is that the antiferromagnetic coupling between Mn spins and the in-plane magnetization of the Mn spins can be explained by neglecting effects due to the presence of the Au(111) surface, while for Ni–TCNQ the metal surface plays a role in determining the absence of magnetic anisotropy in the system.
The Role of Catechins in Cellular Responses to Oxidative Stress
Authors: Bernatoniene Jurga , Kopustinskiene Dalia Marija
Published: April 2018

Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative disease, cancer, cardiovascular diseases, and diabetes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress. This article reviews the biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases.
Dentromers, a Family of Super Dendrimers with Specific Properties and Applications
Authors: Astruc Didier , Deraedt Christophe , Djeda Rodrigue , Ornelas Catia , Liu Xiang , Rapakousiou Amalia , Ruiz Jaime , Wang Yanlan , Wang Qi
Published: April 2018

Dentromers (from dentro, δεντρο: tree in Greek), and meros (μεροσ, in greek: part) are introduced as a family of dendrimers constructed according to successive divergent 1 → 3 branching. The smaller dentromers have 27 terminal branches. With alcohol termini they were originally named arborols by Newkome, who pioneered 1 → 3 constructions of dendrimers and dendrons. Giant dentromers have been constructed and decorated in particular with ferrocene and other redox active groups. The synthesis, specific properties, and applications are examined in this mini review article dedicated to Don Tomalia, with an emphasis on dense peripheral packing favoring the functions of encapsulation, redox sensing, and micellar template for catalysis in water and aqueous solvents.
Patient Education on Oral Anticoagulation
Authors: Hawes Emily M
Published: April 2018

Given the potential harm associated with anticoagulant use, patient education is often provided as a standard of care and emphasized across healthcare settings. Effective anticoagulation education involves face-to-face interaction with a trained professional who ensures that the patient understands the risks involved, the precautions that should be taken, and the need for regular monitoring. The teaching should be tailored to each patient, accompanied with written resources and utilize the teach-back method. It can be incorporated in a variety of pharmacy practice settings, including in ambulatory care clinics, hospitals, and community pharmacies.
Soil Moisture and Vegetation Water Content Retrieval Using QuikSCAT Data
Authors: Oveisgharan Shadi , Haddad Ziad , Turk Joe , Rodriguez Ernesto , Li Li
Published: April 2018

Climate change and hydrological cycles can critically impact future water resources. Uncertainties in current climate models result in disagreement on the amount of water resources. Soil moisture and vegetation water content are key environmental variables on evaporation and transpiration at the land–atmosphere boundary. Radar remote sensing helps to improve our estimate of water resources spatially and temporally. This work proposes a backscattered power formulation for the Ku-band. Li et al. (2010) retrieved soil moisture and vegetation water content values using Windsat data and simultaneous collocated QuikSCAT backscattered power are used to estimate different parameters of backscatter formulation. These parameters are used to estimate soil moisture and vegetation water content using QuikSCAT power everywhere and every day during the summer season. The 2-folded cross validation method is used to evaluate the performance of soil moisture and vegetation water content retrieval. A relatively large correlation is observed between vegetation water content using WindSat and QuikSCAT data in land classes of Evergreen Needleleaf, Evergreen Broadleaf, Deciduous Broadleaf, and Mixed Forests. Similarly, the retrieved soil moisture using QuikSCAT in areas with bare surface fraction of greater than 60% shows relatively high correlation with WindSat values. QuikSCAT satellite collects data over land globally almost every day. Therefore, QuikSCAT data can be used to generate a global map of soil moisture and vegetation water content daily from 2000 to 2009.
Detection of Anomalous Noise Events on Low-Capacity Acoustic Nodes for Dynamic Road Traffic Noise Mapping within an Hybrid WASN
Authors: Alsina-Pagès Rosa Ma , Alías Francesc , Socoró Joan Claudi , Orga Ferran
Published: April 2018

One of the main aspects affecting the quality of life of people living in urban and suburban areas is the continuous exposure to high road traffic noise (RTN) levels. Nowadays, thanks to Wireless Acoustic Sensor Networks (WASN) noise in Smart Cities has started to be automatically mapped. To obtain a reliable picture of the RTN, those anomalous noise events (ANE) unrelated to road traffic (sirens, horns, people, etc.) should be removed from the noise map computation by means of an Anomalous Noise Event Detector (ANED). In Hybrid WASNs, with master-slave architecture, ANED should be implemented in both high-capacity (Hi-Cap) and low-capacity (Lo-Cap) sensors, following the same principle to obtain consistent results. This work presents an ANED version to run in real-time on μ Controller-based Lo-Cap sensors of a hybrid WASN, discriminating RTN from ANE through their Mel-based spectral energy differences. The experiments, considering 9 h and 8 min of real-life acoustic data from both urban and suburban environments, show the feasibility of the proposal both in terms of computational load and in classification accuracy. Specifically, the ANED Lo-Cap requires around 1 6 of the computational load of the ANED Hi-Cap, while classification accuracies are slightly lower (around 10%). However, preliminary analyses show that these results could be improved in around 4% in the future by means of considering optimal frequency selection.
Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier
Authors: Sharif Makhmal Zadeh Behzad , Niro Hassan , Rahim Fakher , Esfahani Golbarg
Published: April 2018

One drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies and mucoadhesive vehicles will help to continuously deliver drugs to the eyes. For this study, we prepared and evaluated the effects of a nanostructure lipid carrier (NLC) on propranolol hydrochloride as a hydrophilic drug model for rabbit corneal permeation. Propranolol hydrochloride NLC was prepared using cold homogenization. The lipid was melted, then the drug and surfactant were dispersed and stirred into the melted lipid. This fused lipid phase was scattered in aqueous solution containing the cosurfactant at 4 °C and then homogenized. We evaluated particle size, drug loading, drug release, and NLC permeability through rabbit cornea as well as the formula’s effect on the cornea. Our results show that drug loading efficiency depended on the surfactant/lipid ratio (S/L) and the percentages of liquid lipid and Transcutol (Gattefosse, Saint-Priest, France) (as solubilizer). Drug release data were evaluated with the Higuchi model and a significant correlation was shown between the S/L ratio and the amount of drug released after 4 and 48 h. NLC formulations improved propranolol hydrochloride permeation. We conclude that the effect of the NLC formulations was due to mucoadhesive and film forming properties.
Heterogeneous Age-Friendly Environments among Age-Cohort Groups
Authors: Park Sojung , Lee Sangchul
Published: April 2018

This study aimed to identify the underlying structures of age-friendly environmental characteristics and examine how they may vary across age-cohort groups based on life satisfaction. We used regionally representative data in South Korea. Exploratory and confirmatory factor analysis were conducted for age-friendly environmental indicators in three age-cohort groups. Regression models examined the association between the environmental factors and life satisfaction in the three age-cohort groups. Across all age groups, three factors converged: neighborhood problems, access to public services and programs, and community engagement. Regression analyses showed the three convergent environmental factors were all significantly associated with life satisfaction across all age-groups, but the association varies across the age-groups. The age-cohort based factor structures and differential patterns of association with well-being provide important background information on designing age-friendly communities.
An Integrated Approach to Evaluate Urban Adaptive Capacity to Climate Change
Authors: Hu Qiangsheng , He Xiaorong
Published: April 2018

Climate change and accelerated urbanization have posed severe challenges to urban development, resulting in a growing series of climate and environmental problems that have a significant impact on industrial production and urban life. In a developing country such as China, more than 57% of the population lives in urban areas. It is vital for these cities to adapt to climate-induced risks. A better understanding of how to improve adaptive capacity could enhance the ability to achieve a desirable state when the city experiences stress. This paper used an integrated approach for evaluating the urban adaptive capacity to climate change. It developed the evaluation index system of urban adaptive capacity (UAC) based on the driver–pressure–state–impact–response model (DPSIR), and adopted grey relational analysis (GRA) and the entropy method to analyze the level of UAC in Changsha, the capital city of Hunan Province, from 2006 to 2015. The results revealed that the UAC of Changsha showed a significant increase from 2006 to 2015. Among the five first-grade indicators, the response dimension had the greatest influence on the improvement of UAC. The study may provide suggestions for adaptive capacity building and sustainable development in other urban areas.
Solid Phase Adsorption Toxin Tracking (SPATT) Technology for the Monitoring of Aquatic Toxins: A Review
Authors: Roué Mélanie , Darius Hélène Taiana , Chinain Mireille
Published: April 2018

The Solid Phase Adsorption Toxin Tracking (SPATT) technology, first introduced in 2004, uses porous synthetic resins capable of passively adsorbing toxins produced by harmful microalgae or cyanobacteria and dissolved in the water. This method allows for the detection of toxic compounds directly in the water column and offers numerous advantages over current monitoring techniques (e.g., shellfish or fish testing and microalgae/cyanobacteria cell detection), despite some limitations. Numerous laboratory and field studies, testing different adsorbent substrates of which Diaion® HP20 resin appears to be the most versatile substrate, have been carried out worldwide to assess the applicability of these passive monitoring devices to the detection of toxins produced by a variety of marine and freshwater microorganisms. SPATT technology has been shown to provide reliable, sensitive and time-integrated sampling of various aquatic toxins, and also has the potential to provide an early warning system for both the occurrence of toxic microalgae or cyanobacteria and bioaccumulation of toxins in foodstuffs. This review describes the wide range of lipophilic and hydrophilic toxins associated with toxin-producing harmful algal blooms (HABs) that are successfully detected by SPATT devices. Implications in terms of monitoring of emerging toxic risks and reinforcement of current risk assessment programs are also discussed.
Assessing Vulnerability to Heat: A Geospatial Analysis for the City of Philadelphia
Authors: Barron Laura , Ruggieri Dominique , Branas Charles
Published: April 2018

Urban heat island (UHI) effect is an increasingly prominent health and environmental hazard that is linked to urbanization and climate change. Greening reduces the negative impacts of UHI; trees specifically are the most effective in ambient temperature reduction. This paper investigates vulnerability to heat in the Philadelphia, Pennsylvania and identifies where street trees can be planted as a public intervention. We used geospatial information systems (GIS) software to map a validated Heat Vulnerability Index to identify vulnerability at the block level. Using a high-low geospatial cluster analysis, we assessed where the City of Philadelphia can most effectively plant street trees to address UHI. This information was then aggregated to the neighborhood level for more effective citizen communication and policymaking. We identified that 26 of 48 (54%) neighborhoods that were vulnerable to heat also lacked street trees. Of 158 Philadelphia neighborhoods, 63 (40%) contained block groups of high vulnerability to either heat or street tree infrastructure. Neighborhoods that were ranked highest in both classifications were identified in two adjacent West Philadelphia neighborhoods. Planting street trees is a public service a city can potentially reduce the negative health impacts of UHI. GIS can be used to identify and recommend street tree plantings to reduce urban heat.
Factors associated with consultation rates in general practice in England, 2013–2014: a cross-sectional study
Authors: Mukhtar Toqir K , Bankhead Clare , Stevens Sarah , Perera Rafael , Holt Tim A , Salisbury Chris , Hobbs FD Richard
Published: April 2018

Background

Workload in general practice has risen during the last decade, but the factors associated with this increase are unclear.

Aim

To examine factors associated with consultation rates in general practice.

Design and setting

A cross-sectional study examining a sample of 304 937 patients registered at 316 English practices between 2013 and 2014, drawn from the Clinical Practice Research Datalink.

Method

Age, sex, ethnicity, smoking status, and deprivation measures were linked with practice-level data on staffing, rurality, training practice status, and Quality and Outcomes Framework performance. Multilevel analyses of patient consultation rates were conducted.

Results

Consultations were grouped into three types: all (GP or nurse), GP, and nurse. Non-smokers consulted less than current smokers (all: rate ratio [RR] = 0.88, 95% CI = 0.87 to 0.89; GP: RR = 0.88, 95% CI = 0.87 to 0.89; nurse: RR = 0.91, 95% CI = 0.90 to 0.92). Consultation rates were higher for those in the most deprived quintile compared with the least deprived quintile (all: RR = 1.18, 95% CI = 1.16 to 1.19; GP: RR = 1.17, 95% CI = 1.15 to 1.19; nurse: RR = 1.13, 95% CI = 1.11 to 1.15). For all three consultation types, consultation rates increased with age and female sex, and varied by ethnicity. Rates in practices with >8 and ≤19 full-time equivalent (FTE) GPs were higher compared with those with ≤2 FTE GPs (all: RR = 1.26, 95% CI = 1.06 to 1.49; GP: RR = 1.36, 95% CI = 1.19 to 1.56).

Conclusion

The analyses show consistent trends in factors related to consultation rates in general practice across three types of consultation. These data can be used to inform the development of more sophisticated staffing models, and resource allocation formulae.
Improving long-term adherence to statin therapy: a qualitative study of GPs’ experiences in primary care
Authors: Krüger Karen , Leppkes Niklas , Gehrke-Beck Sabine , Herrmann Wolfram , Algharably Engi A , Kreutz Reinhold , Heintze Christoph , Filler Iris
Published: April 2018

Background

Statins substantially reduce the risk of cardiovascular disease when taken regularly. Though statins are generally well tolerated, current studies show that one-third of patients discontinue use of statins within 2 years. A qualitative approach may improve the understanding of attitudes and behaviours towards statins, the mechanisms related to discontinuation, and how they are managed in primary care.

Aim

To identify factors related to statin discontinuation and approaches for long-term statin adherence.

Design and setting

A qualitative study of German GPs’ experiences with statin therapy in rural and urban settings in primary care.

Method

Semi-structured interviews (n = 16) with purposefully recruited GPs were recorded, transcribed, and analysed using qualitative content analysis.

Results

Sociodemographic patient factors, the nocebo effect, patient attitudes towards primary prevention, and negative media coverage had significant impacts on statin therapy according to GPs. To overcome these barriers, GPs described useful strategies combining patient motivation and education with person-centred care. GPs used computer programs for individual risk–benefit analyses in the context of shared decision making. They encouraged patients with strong concerns or perceived side effects to continue therapy with a modified medication regimen combined with individual therapy goals.

Conclusion

GPs should be aware of barriers to statin therapy and useful approaches to overcome them. They could be supported by guideline recommendations that are more closely aligned to primary care as well as comprehensible patient information about lipid-lowering therapy. Future studies, exploring patients’ specific needs and involving them in improving adherence behaviour, are recommended.
Performance of a Highly Sensitive, 19-element, Dual-polarization, Cryogenic L-band Phased-array Feed on the Green Bank Telescope
Authors: Roshi D. Anish , Shillue W. , Simon B. , Warnick K. F. , Jeffs B. , Pisano D. J. , Prestage R. , White S. , Fisher J. R. , Morgan M. , Black R. , Burnett M. , Diao J. , Ruzindana M. , Tonder V. van , Hawkins L. , Marganian P. , Chamberlin T. , Ray J. , Pingel N. M. , Rajwade K. , Lorimer D. R. , Rane A. , Castro J. , Groves W. , Jensen L. , Nelson J. D. , Boyd T. , Beasley A. J.
Published: April 2018

A new 1.4 GHz, 19-element, dual-polarization, cryogenic phased-array feed (PAF) radio astronomy receiver has been developed for the Robert C. Byrd Green Bank Telescope (GBT) as part of the Focal L-band Array for the GBT (FLAG) project. Commissioning observations of calibrator radio sources show that this receiver has the lowest reported beam-formed system temperature (T
sys) normalized by aperture efficiency (η) of any phased-array receiver to date. The measured T
sys/η is 25.4 ± 2.5 K near 1350 MHz for the boresight beam, which is comparable to the performance of the current 1.4 GHz cryogenic single-feed receiver on the GBT. The degradation in T
sys/η at ∼4′ (required for Nyquist sampling) and ∼8′ offsets from the boresight is, respectively, ∼1% and ∼20% of the boresight value. The survey speed of the PAF with seven formed beams is larger by a factor between 2.1 and 7 compared to a single-beam system, depending on the observing application. The measured performance, both in frequency and offset from the boresight, qualitatively agrees with predictions from a rigorous electromagnetic model of the PAF. The astronomical utility of the receiver is demonstrated by observations of the pulsar B0329+54 and an extended H ii region, the Rosette Nebula. The enhanced survey speed with the new PAF receiver will enable the GBT to carry out exciting new science, such as more efficient observations of diffuse, extended neutral hydrogen emission from galactic inflows and searches for fast radio bursts.
Improving the Accuracy of Planet Occurrence Rates from Kepler Using Approximate Bayesian Computation
Authors: Hsu Danley C. , Ford Eric B. , Ragozzine Darin , Morehead Robert C.
Published: April 2018

We present a new framework to characterize the occurrence rates of planet candidates identified by Kepler based on hierarchical Bayesian modeling, approximate Bayesian computing (ABC), and sequential importance sampling. For this study, we adopt a simple 2D grid in planet radius and orbital period as our model and apply our algorithm to estimate occurrence rates for Q1–Q16 planet candidates orbiting solar-type stars. We arrive at significantly increased planet occurrence rates for small planet candidates (R

p
 < 1.25 R
⊕) at larger orbital periods (P > 80 day) compared to the rates estimated by the more common inverse detection efficiency method (IDEM). Our improved methodology estimates that the occurrence rate density of small planet candidates in the habitable zone of solar-type stars is

per factor of 2 in planet radius and orbital period. Additionally, we observe a local minimum in the occurrence rate for strong planet candidates marginalized over orbital period between 1.5 and 2 R
⊕ that is consistent with previous studies. For future improvements, the forward modeling approach of ABC is ideally suited to incorporating multiple populations, such as planets, astrophysical false positives, and pipeline false alarms, to provide accurate planet occurrence rates and uncertainties. Furthermore, ABC provides a practical statistical framework for answering complex questions (e.g., frequency of different planetary architectures) and providing sound uncertainties, even in the face of complex selection effects, observational biases, and follow-up strategies. In summary, ABC offers a powerful tool for accurately characterizing a wide variety of astrophysical populations.
Revised Distances to 21 Supernova Remnants
Authors: Ranasinghe S. , Leahy D. A.
Published: April 2018

We carry out a comprehensive study of H i 21 cm line observations and 13CO line observations of 21 supernova remnants (SNRs). The aim of the study is to search for H i absorption features to obtain kinematic distances in a consistent manner. The 21 SNRs are in the region of sky covered by the Very Large Array Galactic Plane Survey (H i 21 cm observations) and Galactic Ring Survey (13CO line observations). We obtain revised distances for 10 SNRs based on new evidence in the H i and 13CO observations. We revise distances for the other 11 SNRs based on an updated rotation curve and new error analysis. The mean change in distance for the 21 SNRs is ≃25%, i.e., a change of 1.5 kpc compared to a mean distance for the sample of 6.4 kpc. This has a significant impact on interpretation of the physical state of these SNRs. For example, using a Sedov model, age and explosion energy scale as the square of distance, and inferred ISM density scales as distance.
On Quasi-biennial Oscillations in Chromospheric Macrospicules and Their Potential Relation to the Global Solar Magnetic Field
Authors: Kiss T. S. , Erdélyi R.
Published: April 2018

This study aims to provide further evidence for the potential influence of the global solar magnetic field on localized chromospheric jets, the macrospicules (MS). To find a connection between the long-term variation of properties of MS and other solar activity proxies, including, e.g., the temporal variation of the frequency shift of solar global oscillations, sunspot area, etc., a database overarching seven years of observations was compiled. This database contains 362 MS, based on observations at the 30.4 nm of the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory. Three of the five investigated physical properties of MS show a clear long-term temporal variation after smoothing the raw data. Wavelet analysis of the temporal variation of maximum length, maximum area, and average velocity is carried out. The results reveal a strong pattern of periodicities at around 2 years (also referred to as quasi-biennial oscillations—QBOs). A comparison with solar activity proxies that also possess the properties of QBOs provides some interesting features: the minima and maxima of QBOs of MS properties occur at around the same epoch as the minima and maxima of these activity proxies. For most of the time span investigated, the oscillations are out of phase. This out-of-phase behavior was also corroborated by a cross-correlation analysis. These results suggest that the physical processes that generate and drive the long-term evolution of the global solar activity proxies may be coupled to the short-term local physical processes driving the macrospicules, and, therefore modulate the properties of local dynamics.
The Austrian school of economics in Russia: From criticism and rejection to absorption and adoption
Authors: Avtonomov Vladimir , Makasheva Natalia
Published: April 2018

Dissemination and adoption of Western economic ideas in Russia have never been a simple process, always bearing marks of the socio-political and ideological circumstances of the country and inner processes in economics, as well as marks of the national intellectual tradition in general. It is not surprising that the history of Austrian economics in Russia was akin to a long road with many windings and turns. We can distinguish three different periods, or waves, each of them rather complex: from the 1890s until the late 1920s (introduction and, to a certain degree, adoption and criticism), from the beginning of the 1930s until the mid-1980s (hostile attitude and ignorance), and from the mid-1980s onwards (rediscovery, dissemination, and adoption).
New identification of the moray eel Gymnothorax minor (Temminck & Schlegel, 1846) in China (Anguilliformes, Muraenidae)
Authors: Li Yuan , Zhang Liyan , Zhao Linlin , Feng Ji , Loh Karhoe , Zheng Xinqing , Lin Longshan
Published: April 2018

A new identification of Gymnothoraxminor (Temminck & Schlegel, 1846) is documented based on morphological characteristics and DNA barcoding. Sixty-one individuals of G.minor were collected from the East China Sea and the South China Sea. This species was previously reported as Gymnothoraxreticularis Bloch, 1795 in China because of the similarity in external shape and color. Gymnothoraxminor can be easily distinguished from G.reticularis by its color pattern of 18–20 irregular dark brown vertical bars and the body having scattered small brown spots. Additionally, the teeth are uniserial on both jaws, and the vertebrae number 137–139. By combining congener sequences of the cytochrome oxidase I (COI) gene from GenBank, two groups were detected among all the COI sequences of the currently named G.minor, which further indicated that two valid species were present based on genetic distance. A divergence also occurred on the number of vertebrae between the northern and southern populations. The phylogenetic and morphological analysis strongly supports that the northern and southern populations of G.minor are two different species. Furthermore, the distribution area of the northern G.minor has expanded southward to 5°15'N in the South China Sea. More specimens of G.minor and G.reticularis are crucial in order to define their geographical distribution boundaries and provide the correct DNA barcoding.
A new species of the land planarian Issoca sheds light on the polyphyletic status of the genus (Platyhelminthes, Tricladida, Geoplaninae)
Authors: Araujo Ana Paula Goulart , Carbayo Fernando
Published: April 2018

A new species of the genus Issoca (Platyhelminthes, Tricladida, Geoplaninae) is described. Issocaassanga sp. n. presents the diagnostic features of the genus, with the exception of the relative position of the subneural parenchymal muscle layer with the cephalic retractor muscle, which are overlapped in the type species of the genus but are intersected in the new species. Rather than a polymorphic character, the relative position of these muscle layers might reflect the polyphyletic status of the genus.
Occurrence of phoresy between Ancistrus multispinis (Actinopterygii: Siluriformes) and Ichthyocladius sp. (Diptera: Chironomidae) in Atlantic forest streams, Southeastern Brazil
Authors: Mattos Tailan Moretti , Carvalho Dandhara Rossi , de Brito Mateus Santos , Araújo Francisco Gerson
Published: April 2018

. Phoretic relationships often bring large advantages to epibionts. By attaching themselves to mobile hosts, epibionts are able to: expand their ranges without spending energy, reduce their risk of being predated, and increase their probability of finding food. We assessed the phoretic relationship between the siluriform fishAncistrusmultispinis(Regan, 1912) and the chironomid larvaIchthyocladiussp. in three streams of the Atlantic forest in southeastern Brazil. We evaluated changes in epibiont distribution throughout the body regions of the host and among three different aquatic systems. We had predicted that certain body regions are more prone to support epibiont attachment, and that epibiont prevalence increases with increased host size and quality of the aquatic system. Three streams (Santana, São Pedro and D’Ouro), tributaries of the Guandu River, were sampled during 2010 and 2011. A total of 102 specimens ofA.multispiniswere collected and analyzed. Epibionts were found in fourteen of fifteen body regions of the host. Observation from scanning electron microscopy revealed that Chironomidae larvae fix themselves to the spicules through the anal prolegs, not at the skin, as previously reported. The amount of epibionts (degree of infestation) was significantly correlated with fish size in the Santana Stream (r = 0.6, p < 0.01), and São Pedro Stream (r = 0.56, p < 0.01), but not in the D’Ouro Stream, the most altered of the three. The presence of epibionts on the body of the fish is directly correlated with the availability of spicules on the fish’s body, the largest numbers of infestations being found in structures associated with swimming (caudal and pectoral fins), since the swimming movement can create favorable conditions (e.g., suspension of organic particles, increasing oxygenation) for the epibiont.
Ferdinand II.: From Inner-Austrian Archduke to Holy Roman Emperor
Authors: Kočevar Vanja
Published: April 2018

This paper provides a biographical and political overview of Archduke Ferdinand’s reign as a provincial prince of Inner Austria up to his election as Emperor of the Holy Roman Empire in 1619. On the basis of subject literature as well as archival materials, light is shed on the political and military situation at the time the Parnassus was printed.
From Milan to Graz: Milanese and Lombard Composers in the Parnassus Musicus Ferdinandaeus
Authors: Toffetti Marina
Published: April 2018

The Parnassus Musicus Ferdinandaeus includes 55 motets attributed to 32 composers and 2 anonymous motets. More than half of the motets are attributed to 18 composers of Lombard origin, including 12 composers active in Milan. Four composers (Arnone, Borgo, Comanedo and Pellegrini) were active at Milan Cathedral, together with the editor of the collection, Giovanni Battista Bonometti, who subsequently moved to the Graz court chapel. The remaining motets in the collection, comprising around half, are attributed to certain musicians in the Graz court chapel, who were likewise Italian by origin. The article examines cultural relations between the Duchy of Milan and the Graz court, the biography of Bonometti and the characteristics of Milanese motets.
Pietro Antonio Bianco’s Missa Percussit Saul mille: A Precursor of the Habsburg Imperial musica politica of the Seventeenth Century
Authors: Grabnar Klemen
Published: April 2018

The article establishes the most appropriate context for understanding Pietro Antonio Bianco’s Missa Percussit Saul mille. In 1601 the Inner-Austrian Archduke Ferdinand II appears to have commissioned a Mass based on Giovanni Croce’s militaristic motet Percussit Saul mille for a solemn Mass celebrated before his departure for the battle of Kanisza. Its composition was entrusted to Ferdinand’s kapellmeister, Bianco. The latter’s Mass seems to be a musical statement of political ideas and demonstrates the function, convention and ideology of ceremonial sacred music at the Graz court around the turn of the sixteenth century. It reflects a political-musical culture that flourished even more greatly after Ferdinand became Emperor.
Giovanni Sansoni: Cornettist, Maestro dei concerti and Composer in Venice, Graz and Vienna
Authors: Seifert Herbert
Published: April 2018

Sansoni was a player of the cornetto, trombone and bassoon at San Marco in Venice, at the court in Graz and finally at the Imperial chapel in Vienna, where he died as the senior instrumentalist. He composed a few motets. Two of them were printed in 1615 and are the objects of an analysis.
Glasbeno mecenstvo habsburške dinastije v jezuitski Šleziji
Authors: Jeż Tomasz
Published: April 2018

Eden od pomembnih dejavnikov v rekatolizaciji Šlezije v 17. stoletju je bila glasbena umetnost po vzorih sodobnega italijanskega sloga, ki so jo širili predvsem krogi, povezani z jezuiti. Finančno jih je podpirala tedanja politična elita obravnavanega prostora, pretežno povezana s Habsburžani.