bluuebunny/crossref_metadata_2025 huggingface dataset:
СУЧАСНІ ПРИНЦИПИ ФОРМУВАННЯ ПРОФЕСІЙНОЇ ЕТИКИ МАЙБУТНІХ СОЦІАЛЬНИХ ПРАЦІВНИКІВ В УНІВЕРСИТЕТАХ
Authors: Zozulyak-Sluchyk Rоksolyana
Published: December 2019

У статті автор розкрив сутність дефініції «принцип». Визначив та детально обґрунтував роль сучасних принципів у формуванні професійної етики майбутніх соціальних працівників в університетах, які стали підґрунтям розроблення педагогічної системи професійної підготовки фахівців. У дослідженні виокремлено специфічні принципи: професійно-аксіологічної спрямованості; єдності теорії професійної етики та моральної практики (фахової моральності); системності формування професійної етики; міждисциплінарністі у формуванні професійної етики; єдності моральної свідомості й моральної діяльності; комплементарності; інтеграції і взаємовпливу етичного та професійного знання; проектування особистісної траєкторії формування; морально-етичної рефлексивної спрямованості процесу навчання студентів спеціальності «Соціальна робота»; морального вибору; фасилітації; академічної доброчесності.

Розглянуто загальнодидактичні принципи діяльності університетів: об’єктивності, зв’язку теорії з практикою, систематичності, наочності й різноманітності методів, міцності засвоєння знань, умінь і навичок. Також у роботі проаналізовано загальнопедагогічні принципи: гуманізації та демократизації, науковості, наступності і послідовності, безперервності, динамічності, особистої активності.
Evaluation of some blood liver parameters in cows with subclinical and clinical ketosis
Authors: Marutsova V.J. , Marutsov P.D. , Binev R. G.
Published: December 2019

The purpose of the present study was to establish the changes in some blood liver parameters in cows in different physiological conditions with subclinical (SCK) and clinical ketosis (CK). The study was performed on 157 Holstein cows with annual milk yield of 9,000–11,000 L. The animals were divided into 3 groups: I group – pregnant cows (from day 15 to day 0 pre-calving); II group – recently calved (from day 0 to day 15 postpartum) and III group – lactating (from day 30 to 45 postpartum). Blood concentrations of β-hydroxybutyric acid (ВНВА) (mmol/L), glucose (mmol/L), total protein (g/L), albumin (g/L) and total bilirubin (μmol/L) were assayed in all cows. The animals were divided in groups with SCK and CK according to their blood BHBA levels. It was established, that the con-centrations of total bilirubin were statistically significantly elevated vs control groups, while blood glucose, total protein and albumin values decreased, reflecting the impaired liver function in cows with SCK and CK.
Gastrointestinal helminth fauna and helminth communities of bleak (Alburnus alburnus, L. 1758) from lower section of Danube River
Authors: Chunchukova M. , Kirin D. , Kuzmanova D.
Published: December 2019

The present study presents the results from examinations of bleak’s endohelminth species and structure of helminth communities from the Bulgarian part of the Lower Danube River. In 2015 and 2016, on a seasonal manner, 91 specimens of Alburnus alburnus (Linnaeus, 1758) (bleak) were examined with standard techniques for parasites. Five species of parasites: Nicolla skrjabini (Ivanitzky, 1928), Ligula intestinalis (Linnaeus, 1758), Acanthocephalus lucii (Müller, 1776), Pomphorhynchus laevis (Müller, 1776) and Contracoecum microcephalum (Stossich, 1890), larvae were identified. The analysis of the dominant structure of the found parasite species is presented to the component and infracommunities levels. All parasite species were accidental for the parasitic communities of examined fish with the exception of P. laevis and N. skrjabini. P. laevis was a core parasite species and N. skrjabini was a component parasite species for the helminth communities of bleak. The parasite communities of A. alburnus were discussed and compared with previous research data on parasite communities of bleak from River Danube in Bulgaria. New data for helminths and helminth communities of A. alburnus from Danube River (biotope Vetren) and their seasonal occurrence are presented.
New records of Cladomelea from South Africa, including the first records of C. longipes (O. Pickard-Cambridge, 1877) (Araneae, Araneidae) outside its type locality
Authors: Dippenaar-Schoeman Anna Sophia , Foord Stefan Hendrik
Published: December 2019

We present the first records of the bolas spider, Cladomelea longipes (O. Pickard-Cambridge, 1877), beyond its type locality, resulting in a considerable extension of its geographic range in Africa. We compare C. longipes with the two other species of Cladomelea known from South Africa, C. akermani Hewitt, 1923 and C. debeeri Roff & Dippenaar-Schoeman, 2004. Images of live specimens and a distribution map are provided. Cladomelea longipes is very rare locally but has a relatively large geographical distribution in the Afrotropical Region.
A violência do capital objetivada n’O Mecanismo da televisão
Authors: Carlos de Souza André Barcellos
Published: December 2019

Este texto discute como a violência do capital é objetivada na televisão em geral e na série televisiva da Netflix O Mecanismo, de José Padilha. O autor/diretor, ao estabelecer n’O Mecanismo a corrupção como o “câncer” da sociedade capitalista, deliberadamente elege algo da ordem do subjetivo, da moral, como causa das condições desiguais da sociedade do capital, deslocando intencionalmente ou não as determinações sociais objetivas para o plano subjetivo. Problematiza também as relações contraditórias entre as relações sociais de produção e as forças produtivas na arte e na indústria cultural, fundamentando-se nas contribuições teóricas de Marx, Adorno e Horkheimer. Ademais, postula que a televisão brasileira, imbricada com o capitalismo tardio, é um objeto cujo procedimento de razão atua não apenas na esfera da reprodução da cultura, mas, fundamentalmente, na sua produção pela via da formação do público. Nesse sentido, discute os limites e as possibilidades dos processos formativos e educativos da televisão.
Presentation of the Dossier
Authors: Grenzer - Translation of João Batista Ribeiro Santos Matthias
Published: December 2019

The Pentateuch is a cultural heritage of Humanity. The world narrated in it belongs to the second millennium B.C., and the narratives, poems, and sets of laws contained therein were composed during the first six centuries of the first millennium B.C. On the one hand, by bringing together epic, lyrical, and legal poetry, the one hundred and eighty-seven chapters constitute, in the form of five books, a masterpiece in the history of literature. On the other hand, it is literature that proposes to cultivate memory, either in relation to the narrated world, or in view of the period of its composer, sometimes narrating, sometimes legislating, sometimes singing. Moreover, as literature aimed at history, the texts of the Pentateuch promote enormous theological reflection. The main goal seems to be to think God. Thus the first five books of the Jewish Bible and the Christian Bible, with their narrated models of faith and behavior, turned into poems and defined by legal formulations, became the foundational reference for the religion of ancient Israel, of which Judaism was born and, from the latter, Christianity. Also Jesus of Nazareth, in the four New Testament Gospels, is presented in relation to Abraham and Moses, and stands out as a unique teacher with regard to the laws contained in the Pentateuch.
Aproximação narrativa a Ex 3,1-6
Authors: Fernandes Leonardo Agostini
Published: December 2019

ResumoEx 3,1-6 abre, para a história do antigo Israel, o ingresso de Moisés no misterioso desígnio salvífico de Deus, representado no fenômeno da sarça ardente e penetrado de sentido quanto ao lugar da revelação: “o solo é santo” (Ex 3,5). O protagonismo de Moisés não depende da sua capacidade de enfrentar o deserto ou da sua capacidade de querer descobrir o que está por detrás do mistério, mas na sua capacidade de ver, de ouvir e de responder a Deus com reverência, despojamento e assumir a missão. Este artigo avalia elementos da narrativa e se subdivide em quatro tópicos: contexto; texto; estrutura do texto; lógica da narrativa.Palavras-chave: Análise narrativa, Livro do Êxodo, Vocação, Missão.
Transgraniczny przepływ danych osobowych wiernych Kościoła katolickiego z Polski – na przykładzie kazusu
Authors: Chojara-Sobiecka Małgorzata , Karsten Kinga , Kroczek Piotr
Published: December 2019

Artykuł pokazuje na przykładzie kazusu praktyczne zastosowanie regulacji dotyczących ochrony danych osobowych w procesie transgranicznego przekazywania danych przez kościelne publiczne osoby prawne. Po przedstawieniu danych kazusu autor artykułu czyni kilka uwag dotyczących obowiązujących regulacji i ich zastosowania. Na końcu artykułu zostaje sformułowany ogólny wniosek, który nakazuje administratorom podejmować transgraniczne przekazywanie danych z wielką ostrożnością.
Pojęcie zamieszkania w obowiązującym prawie kanonicznym
Authors: Skonieczny Piotr
Published: December 2019

Artykuł przedstawia pojęcie zamieszkania w prawie kanonicznym łacińskim i wschodnim z punktu widzenia doktryny kanonistycznej. Autor twierdzi, że w obowiązującym prawie kanonicznym brak definicji legalnej zamieszkania. Należy ją zatem wyprowadzić z innych przepisów, głównie o jego nabywaniu i utracie, wychodząc przed wszystkim z założeń teoretyczno- i historyczno-prawnych tej instytucji (1.1.). Opisując tradycyjne elementy zamieszkania (corpus i animus), autor zauważa pewną nieelastyczność pojęcia domicylu (2.1.3.). Posługując się zaś kryterium woli, wskazuje trzy teorie koncepcji domicylu w kanonistyce (3.1.). Opowiada się za teorią mieszaną lub dwudzielną zmienioną i wyróżnia zamieszkanie właściwe (a w nim: zamieszkanie swobodne oraz zamieszkanie faktyczne) i niewłaściwe (czyli ustawowe; 3.1.3.).
Are Childhood Sexual Abuse and Intimate Safety in Adult Intimate Relationships Correlated?
Authors: Jerebic Drago , Jerebic Sara
Published: December 2019

Individuals who have experienced childhood sexual abuse report numerous problems in intimate relationships, including their physical and sexual experience. Satisfying sexuality arises from intimate safety, the prerequisite for which is mutual trust, which, however, can be impaired due to betrayal in individuals who were traumatized by sexual abuse in their childhood. In a study with 168 participants, we were interested in differences in intimate safety within intimate relationships (measured by the ISQ – Intimate Safety Questionnaire subscale which refers to sexual safety). Differences were studied within two groups of couples – those who had experienced childhood sexual abuse and those who had never experienced the sexual abuse in childhood. We found that among the participating couples, in 42 (50%) couples at least one of the partners experienced at least one type of sexual abuse. One or more types of sexual abuse in childhood were experienced by 12 (14%) men and 39 (46.4%) women. We also found that in couples who had experienced sexual abuse in childhood and couples who had not, there is a difference in intimate safety in their sexual life. The couples who had not experienced sexual abuse in childhood reported statistically significantly higher sexual safety in their intimate relationships. We can conclude that childhood sexual abuse trauma is expressed in sexual intimacy with mistrust, which through the decreased feeling of safety inhibits individuals’ vulnerability and reduces the opportunity to create intimacy. The survey was limited by a biased sample.
Sabetayist Ermişler
Authors: YILDIRIM Meltem
Published: December 2019

Geçmişten günümüze Yahudi mistisizmi, Sabetay
Sevi ve Sabetaycılık ile ilgili birçok eser yazılmıştır. Bu eserler arasında en
fazla dikkat çeken, Kabala’yı akademik alanda çalışılan ve bilimsel metotlarla
incelenen bir konu haline getiren Gershom Scholem’in çalışmasıdır. Goldish ise Sabetay Sevi ile ilgili geleneksel bakış açısına karşı tarihi perspektiften yaklaşmaktadır.
Distance Professional Training of Undergraduate Economics Students in Russia
Authors: Sirazetdinova Miliausha Faritovna , Lukmanova Rushana Khusainovna , Stoletov Anatoliy Igorevich
Published: December 2019

The research aims to identify the positive and negative experience of application distance learning for Economics students in Russia. Unlike most papers studying the motivation of applicants to choose economic distance education, the paper discusses the factors of its development in Russia, which differs both from those in the US and Europe, and from other specialties in Russia. The explanatory material is the statistics of admissions ratesand the analysis of universities’ location.
Identity Retrieval and Development in the Conflict of Paradigmatic Dichotomy
Authors: Bairašauskienė Lina
Published: December 2019

This article presents basic insights on the concept of identity unfolding the dichotomy of viewpoints on this social construct. The concept can be researched following logical, ontological, or epistemic perspectives. From the historic point of view identity retrieval was associated with the restructuration process of society that continued from the epochs of Renaissance and Enlightenment and has been emphasized in modern and postmodern changes. It should be noted that scientific debates highlight the dichotomy between two approaches to identity. The issue stands in regard to what degree and whether identities have been constructed by the individual who is independent to choose a set of identities (Kant) or the degree to which the identities have been determined culturally and individually (Hegel).The variety of notions has made a proposition that identity is interrelated with social interaction which highly influences individual’s conceptualization of selfness and otherness. Thus, the conclusion that identity is socially constructed can be drawn after thorough literature review. What is more, identity can be negotiated through interactions between individuals that result in identity change, determination, defense or maintenance. The multiplicity of scientific approaches to identity proves the importance and actuality of debates on identity issues involving different viewpoints and argumentation concerning issues in educational sciences.
Olanzapine Versus Haloperidol for Treatment of Delirium in Patients with Advanced Cancer: A Phase III Randomized Clinical Trial
Authors: van der Vorst Maurice J.D.L. , Neefjes Elisabeth C.W. , Boddaert Manon S.A. , Verdegaal Bea A.T.T. , Beeker Aart , Teunissen Saskia C.C. , Beekman Aartjan T.F. , Wilschut Janneke A. , Berkhof Johannes , Zuurmond Wouter W.A. , Verheul Henk M.W.
Published: December 2019

Background

Treatment of delirium often includes haloperidol. Second-generation antipsychotics like olanzapine have emerged as an alternative with possibly fewer side effects. The aim of this multicenter, phase III, randomized clinical trial was to compare the efficacy and tolerability of olanzapine with haloperidol for the treatment of delirium in hospitalized patients with advanced cancer.

Materials and Methods

Eligible adult patients (≥18 years) with advanced cancer and delirium (Delirium Rating Scale-Revised-98 [DRS-R-98] total score ≥17.75) were randomized 1:1 to receive either haloperidol or olanzapine (age-adjusted, titratable doses). Primary endpoint was delirium response rate (DRR), defined as number of patients with DRS-R-98 severity score <15.25 and ≥4.5 points reduction. Secondary endpoints included time to response (TTR), tolerability, and delirium-related distress.

Results

Between January 2011 and June 2016, 98 patients were included in the intention-to-treat analysis. DRR was 45% (95% confidence interval [CI], 31–59) for olanzapine and 57% (95% CI, 43–71) for haloperidol (Δ DRR −12%; odds ratio [OR], 0.61; 95% CI, 0.2–1.4; p = .23). Mean TTR was 4.5 days (95% CI, 3.2–5.9 days) for olanzapine and 2.8 days (95% CI, 1.9–3.7 days; p = .18) for haloperidol. Grade ≥3 treatment-related adverse events occurred in 5 patients (10.2%) and 10 patients (20.4%) in the olanzapine and haloperidol arm, respectively. Distress rates were similar in both groups. The study was terminated early because of futility.

Conclusion

Delirium treatment with olanzapine in hospitalized patients with advanced cancer did not result in improvement of DRR or TTR compared with haloperidol. Clinical trial identification number. NCT01539733. Dutch Trial Register. NTR2559.
Opioid Prescribing Trends in Women Following Mastectomy or Breast-Conserving Surgery Before and After the 2014 Federal Reclassification of Hydrocodone
Authors: Gibson Derrick C. , Chou Lin-Na , Raji Mukaila A. , Baillargeon Jacques G. , Kuo Yong-Fang
Published: December 2019

Background

Given concerns about suboptimal pain management for actively treated cancer patients following the 2014 federal reclassification of hydrocodone, we examined changes in patterns of opioid prescribing among surgical breast cancer patients.

Materials and Methods

Data from a large nationally representative commercial health insurance program from 2009 to 2017 were used to identify women aged 18 years and older who were diagnosed with carcinoma in-situ or malignant breast cancer and received breast-conserving surgery or mastectomy from 2010 to 2016. Generalized linear mixed models were used to estimate the adjusted odds ratio (aOR) for receipt of ≥1-day, >30-day, or ≥ 90-day supply of opioids in the 12 months following surgery adjusting for demographics, cancer treatment–related characteristics, and preoperative opioid use.

Results

A total of 60,080 patients were included in the study. Surgically treated breast cancer patients in 2015 (aOR = 0.90, 0.84–0.97) and 2016 (aOR = 0.80, 0.74–0.86) were less likely to receive ≥1-day supply of opioid prescriptions when compared with patients in 2013. Patients who had surgery in 2015 (aOR = 0.89, 0.81–0.98) and 2016 (aOR = 0.80, 0.73–0.87) were also less likely to receive >30-day supply of prescription opioids in the 12 months following surgery. However, only surgical breast cancer patients in 2016 were less likely to receive ≥90-day supply (aOR = 0.86, 0.76–0.98).

Conclusion

Surgically treated breast cancer patients are less likely to receive short- and long-term opioid prescriptions following the implementation of hydrocodone rescheduling. Further studies on the potential impact of federal policy on cancer patient pain management are needed.
ZSM-5 Zeolitinin Yüzey Özelliklerinin Ters Gaz Kromatografisiyle Belirlenmesi
Authors: BİLGİÇ Ceyda
Published: December 2019

Zeolitler, simektit grubunun mikro gözenekli üyeleridir ve endüstriyel uygulamalarda geniş kullanım alanı bulurlar. Zeolitlerin yüzey, morfolojik, mineralojik ve fizikokimyasal özellikleri farklı aletli analiz teknikleri ile incelenmiştir. Yüzey fonksiyonel grupları Fourier dönüşümlü kızılötesi (FTIR) spektrumları ile belirlenmiştir. Malzemelerin morfolojisi ve yüzey fonksiyonel grupları taramalı elektron mikroskobu (SEM) görüntüleri ve X ışını kırınım desenleri yardımıyla analiz edilmiştir. Zeolitin, Brunauer-Emmett-Teller (BET) yüzey alanı, gözenek hacmi, gözenek büyüklüğü dağılımı ve ortalama gözenek çapı da dâhil gözenek özellikleri, -196 ○C de N2 atmosferinde fiziksel adsorpsiyon ile belirlenmiştir. Zeolit yüzeyini karakterize etmek için ters gaz kromatografisi (TGK) uygulanmıştır. ZSM-5 zeoliti, Yüzey özellikleri, Morfolojik özellikler, Fizikokimyasal özellikler
The Effect of Zr on LM6 Aluminum Alloy
Authors: TUNÇAY Tansel
Published: December 2019

In this study, the effect of
Zr amount on LM6 alloys which were produced by conventional casting method and
contained different amounts of Zr (0.05% and 0.15) on the microstructure and  mechanical properties of the alloys was
investigated. In addition, produced alloys were modified with 200-250 ppm
Strontium (Sr). optic microscope (OM) and scanning electron microscopy (SEM /
EDS analysis) were used for microstructure analysis. The hardness and tensile
tests of the alloys which were modified by Sr and alloyed with different
amounts of zirconium were performed. As a result of the studies that were done,
it was determined in the images of optical microscope (OM) and scanning
electron microscope (SEM) that the morphology of Al-Si-Fe phase changed
depending on the addition of Zr, and that Al-Si-Fe intermetalics having
different amounts of Zr composed. While the highest level of percent elongation
was obtained from the Al12Si alloy, the highest level of hardness and maximum
tensile strength were obtained from the LM6 alloy modified by strontium. The
highest level of yield strength was obtained from LM6 alloy which was alloyed
with 0.05 Zr. It was found that the amount of added Zr did not show a
significant difference at the maximum tensile strength level of Al12Si alloy.
Expression of the anti-Mullerian hormone, kisspeptin 1, and kisspeptin 1 receptor in polycystic ovary syndrome and controlled ovarian stimulation rat models
Authors: Risvanli Ali , Ocal Halis , Timurkaan Necati , Ipek Pınar , Seker Ibrahim , Karabulut Burak
Published: December 2019

Polycystic ovary syndrome represents a significant cause of female infertility. The aim of this study was to investigate the expression of anti-Mullerian hormone (AMH), kisspeptin 1 (KISS-1), and kisspeptin 1 receptor (KISS1r) in rat models of polycystic ovary syndrome (PCOS) and controlled ovarian stimulation (COS). For this purpose, 28 rats were assigned into four groups. Estrus and Diestrus groups consisted of rats in estrus and diestrus phases, respectively, while COS and PCOS groups consisted of rats with induced COS and PCOS, respectively. The serum AMH, KISS-1, and estradiol levels, and ovarian KISS1r levels were analyzed by enzyme-linked immunosorbent assay. Furthermore, histopathological analysis of the ovary tissue was done and ovarian KISS-1 expression was determined by immunohistochemical assay. The results revealed that ovarian KISS1r levels were higher in the Estrus (1271.43±51.98 pg/mL) and COS (1191.43±85.67 pg/mL) groups, compared to Diestrus and PCOS groups. The highest level of AMH was found in the Estrus group (16.91±2.12 ng/mL). The results indicate that AMH had no effect on the development of COS and PCOS, while  KISS-1 was found to affect the development of COS in rats.
MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis
Authors: Zhang Junjun , Li Qian , Xue Bing , He Rui
Published: December 2019

Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved long noncoding RNA, which has been related to various pathological processes, including cancer. The role and mechanism of MALAT1 in colon cancer are not clear. We investigated MALAT1 expression in colon cancer tissues, the effect of MALAT1 on proliferation and apoptosis of SW480 cells, and the signaling pathway involved in the MALAT1 effects. MALAT1 expression was determined in 60 colon cancer and para-carcinoma tissues using reverse transcription polymerase chain reaction (RT-PCR). Knockdown of MALAT1 in SW480 cells was induced by small interfering RNA (siRNA), and the cells were divided into three groups: untreated control, nonsense siRNA-treated control, and MALAT1 siRNA-treated group. SW480 cell apoptosis was assessed using TUNEL assay and flow cytometry. Apoptosis-related and Wnt/β-catenin signaling pathway-related proteins were detected by Western blotting in SW480 cells. SW480 cell proliferation was assessed by CCK-8 assay. MALAT1 expression was significantly higher in colon cancer vs. para-carcinoma tissues. Knockdown of MALAT1 by siRNA increased the number of apoptotic cells and the apoptosis rate at 24 h post-transfection in SW480 cells. Bcl2 associated X protein (Bax) expression was increased, B-cell lymphoma 2 (Bcl-2) expression was decreased, and the ratio of cleaved caspase-3 to truncated caspase-3 was increased in MALAT1 siRNA-transfected SW480 cells. MALAT1 knockdown decreased the proliferation of SW480 cells at 24 h, 48 h, and 72 h post-transfection. Wnt and β-catenin expression was inhibited in MALAT1 siRNA-transfected SW480 cells. Inhibition of MALAT1 expression in colon cancer may promote apoptosis and hinder cell proliferation by suppressing the activation of Wnt/β-catenin signaling pathway.
Inhibition of miR-9 decreases osteosarcoma cell proliferation
Authors: Gang Wu , Tanjun Wei , Yong Huang , Jiajun Qin , Yi Zhang , Hao Hu
Published: December 2019

Osteosarcoma (OS) is the most common primary bone tumor that affects adolescents and young adults. Disruption of microRNA (miRNA) regulation is well established in the pathophysiology of different cancers, including OS. Increased expression of miR-9 in OS positively correlates with the tumor size, clinical stage, and distant metastasis. In the present study, we used two different OS cell lines, MG-63 and Saos-2, as in vitro models. Small interfering RNA against miR-9 and miR-9 mimics were used to study the function of miR-9 in these two cell lines. We determined the effect of miR-9 inhibition on cell proliferation, cell cycle, apoptosis, and the protein expression of different genes. Our results demonstrated that miR-9 knockdown in the human OS cell lines inhibits their metastatic potential, as determined by decreased cell proliferation and cell cycle arrest, decreased invasion, and increased apoptosis. The western blot analysis showed that cadherin-1 (CDH1), matrix metalloproteinase 13 (MMP-13), forkhead box O3 (FOXO3a), Bcl-2-like protein 11 (BCL2L11), and β-catenin (CTNNB1) are involved in miR-9 signaling. Moreover, miR-9 mimics rescued the effects caused by the inhibition of miR-9 in the OS cell lines. Our findings suggest that miR-9 is important for mediating OS cell migration, invasion, metastasis, and apoptosis. Inhibition of miR-9 could be further explored as a therapeutic target to treat OS.
Human brucellosis in pregnancy – an overview
Authors: Bosilkovski Mile , Arapović Jurica , Keramat Fariba
Published: December 2019

Human brucellosis during pregnancy is characterized by significantly less pronounced adverse obstetric outcomes than in animals, but with remarkably more adverse obstetric outcomes when compared to healthy pregnant women. Seroprevalence of brucellosis in pregnancy and cumulative incidence of brucellosis cases per 1000 delivered obstetrical discharges in endemic regions were reported to be 1.5–12.2% and 0.42–3.3, respectively. Depending on the region, frequency of pregnant women in the cohorts of patients with brucellosis was from 1.5% to 16.9%. The most common and the most dramatic unfavorable outcomes during brucellosis in pregnancy are the obstetric ones, manifested as abortions (2.5–54.5%), intrauterine fetal death (0–20.6%) or preterm deliveries (1.2–28.6%), depending on the stage of pregnancy. Other unfavorable outcomes due to brucellosis are addressed to infant (congenital/neonatal brucellosis, low birth weight, development delay or even death), the clinical course of disease in mother and delivery team exposure. When diagnosed in pregnant women, brucellosis should be treated as soon as possible. Early administration of adequate therapy significantly reduces the frequency of adverse outcomes. Rifampicin in combination with trimethoprim-sulfamethoxazole for 6 weeks is the most commonly used and recommended regimen, although monotherapies with each of these two drugs are also widely used while waiting for the results from prospective randomized therapeutic trials. As no effective human vaccine exists, screening of pregnant women and education of all women of childbearing age about brucellosis should be compulsory preventive measures in endemic regions.
A fast and simple fluorometric method to detect cell death in 3D intestinal organoids v1
Authors: J. Bode Konstantin , Mueller Stefanie , Schweinlin Matthias , Metzger Marco , Brunner Thomas
Published: December 2019

This protocol describes a novel fluorometric method for the quantitative measurement of specific organoid cell death. Organoids are stained simultaneously with the cell impermeable nuclear dye propidium iodide and cell permeable Hoechst 33342. While Hoechst allows in-well normalization to cell numbers, propidium iodide detects relative proportion of dead cells independent of hydrogel. Measurement and analysis time, as well as usability are drastically improved in comparison to other established methods. Parallel multiplexing of this method with established assays measuring mitochondrial activity further enhances its applicability in personalized medicine and drug discovery.
gRNA design and cloning with BbsI into Loop plasmid L1_lacZgRNA-Ck2/3 v1
Authors: Frangedakis Eftychis , Tomaselli Marta , Sauret-Gueto Susana
Published: December 2019

This protocol explains how to design and clone the guide RNA target sequence into a L1 plasmid ready to accept the gRNA by cloning with BbsI. L1 plasmids are L1_lacZgRNA-Ck2 and L1_lacZgRNA-Ck3. If one gRNA target sequence is cloned into the Ck2 plasmid and another one into Ck3 one, the two L1_gRNA transcription units can be combined with an antibiotic resistance transcription unit and a MpEF1α:Cas9 transcription unit via L2 SapI Loop assembly. This allows for dual gRNA editing.
Use of medications for the prevention of cardiovascular events in the Colombian population with type 2 diabetes mellitus: Comparison of 2008 and 2018. v1
Authors: Machado Alba Jorge , E. Machado-Duque Manuel , Arturo Garcia Diego , Hiromi Emura Vélez Melissa , Gaviria-Mendoza Andrés
Published: December 2019

Background: To estimate the proportion of patients with type 2 diabetes mellitus (T2DM) undergoing drug therapy for cardiovascular prevention (aspirin and statins) in Colombia and to describe the change in patterns of use between 2008 and 2018. Methods:This was a descriptive study comparing prescriptions for aspirin and statins in 2008 and in 2018 in outpatients diagnosed with T2DM. The records were obtained from a national drug claim database. The proportion of use of cardiovascular prevention drugs and antidiabetic drugs, medications for comorbidities, and sociodemographic variables were analyzed for both periods. Results:A total of 26742 patients were identified in 2008 and 188321 in 2018 with a diagnosis of T2DM treated with antidiabetic drugs, of which 57.5% and 44.2% received aspirin and 44.9% and 60.2% received statins, respectively. The use of high-intensity statins increased from 1.1% in 2008 to 95.2% in 2018. The probabilities of receiving drugs for the prevention of cardiovascular risk in 2008 and in 2018 were higher for men (OR: 1.12, 95% CI: 1.06-1.17 and OR: 1.26, 95% CI: 1.23-1.28, respectively), for those over 75 years of age (OR: 6.5, 95% CI: 5.3-7.9 and OR: 5.8, 95% CI: 5.4-6.2) and for those who also received clopidogrel (OR: 5.8, 95% CI: 4.4-7.6 and OR: 2.2, 95% CI: 2.1-2.4). Conclusion:The use of high-intensity statins in patients with T2DM has increased significantly in the last decade, which should reduce cardiovascular events, morbidity and mortality, especially in adults over 75 years of age.
Embedding and freezing fresh human tissue in OCT using isopentane v3
Authors: Roberts Kenny , Tuck Liz
Published: December 2019

For many cutting-edge spatial transcriptomic analysis methods, it is essential to prepare and store tissue in a manner that preserves RNA integrity, tissue morphology, and spatial orientation. This protocol describes the process of freezing fresh or fixed and cryoprotected tissues in optimal cutting temperature compound (OCT) using an isopentane-dry ice slurry. Rapid controlled freezing preserves RNA and mimises ice damage, while embedding in OCT prepares tissues for future cryosectioning.
Hydrotropic Pulping of Miscanthus to Obtain Pulp
Authors: Pavlov Igor N. , Kukhlenko Alexey A. , Sevastyanova Yulia V.
Published: December 2019

The hydrotropic pulping of crushed straw of Miscanthus sacchariflorus Andersson to produce pulp was studied herein. A concentrated sodium benzoate solution was used as the reagent. Established regularities of the pulping temperature and time effects on delignification quality attributes such as pulp yield and residual lignin content in the pulp. The generalized arithmetic-mean optimization parameter enabled hydrotropic pulping optimum conditions to be identified to obtain hard pulp fit. Experimentally displayed the possibility of using cellulose for the manufacture of special paper grades
Optimization of the Process of Abies Wood Peroxide Delignification in the Medium “Formic Acid-Water” in the Presence of TiO₂ Catalyst
Authors: Garyntseva Natalya V. , Sudakova Irina G. , Chudina Anna I. , Malyar Yuri N. , Kuznetsov Boris N.
Published: December 2019

The experimental and mathematical optimization of abies wood peroxide delignification process in the formic acid – water medium in the presence of TiO₂ catalyst was carried out. It was established that in the temperature range 70-100 °С the rate constants of the delignification process vary between 0.4 and 3.2 · 10-4 min-1. The optimal parameters for the production of cellulose product with a residual lignin content of ≤ 3 wt.% were determined (temperature 100 °С, concentration Н₂О₂ 10 wt.%, НCOOН 38 wt.%, LWR 15, time 4 h). The features of abies wood peroxide delignification processes in the presence of TiO₂ catalyst in “ formic acid – water” and “acetic acid – water” were compared. It was shown the possibility of abies wood fractionation in the medium “ formic acid-water” to high-quality cellulose with the yield of 94 wt.% (the content of residual lignin 2.3 wt.%) and to low molecular weight lignin with the yield of 21 wt.% (average molecular weight 1854 g/mol and polydispersity 1.65). The obtained chemically active lignin can be used for the production such valuable products as enterosorbents, nanoporous carbon materials, aerogels
Chemoselective Hydrogenation of –C=O Bond in Multiple Unsaturated Compounds Over Metals Supported on Mesoporous Materials
Authors: Simakova Irina L. , Demidova Yuliya S. , Simakov Andrey V. , Murzin Dmitry Yu.
Published: December 2019

Liquid-phase hydrogenation of crotonaldehyde in non-polar and polar solvents was studied on monometallic Pd, Pt, Ir, Re catalysts using mesoporous Sibunit and Al2O3 as supports. In the presence of Pd the -C=C- bond of crotonaldehyde was preferably hydrogenated to form butanal, while butanal and crotyl alcohol are formed over Ir catalysts. Crotonaldehyde hydrogenation in 1,4-dioxane did not exhibit further butanal to butanol hydrogenation. Application of Re as a catalyst leads to formation of crotyl alcohol, with activity being, however, twofold lower than of Ir catalysts. Pt/C is almost inactive in the hydrogenation of crotonaldehyde. Formation of crotyl alcohol occurs most efficiently over Ir/Al2O3 in aprotic nonpolar solvents (decane), with selectivity to crotyl alcohol increasing with temperature showing 30% at 25% conversion under 180 °C and hydrogen pressure 0.84 MPa. Crotonaldehyde hydrogenation in a polar protonic solvent (ethanol) results in butanal ac
IMMIGRATION PROBLEMATICS IN THE NARRATIVE DISCOURSE OF JOSEF IGNACY KRASZEWSKI
Authors: Baidatska Svitlana
Published: December 2019

The article devotes to the immigration problematics in the creative work of Józef Ignacy Kraszewski – the leading spiritual and intellectual leader of Polish immigration after the January uprising. The contribution of a writer to the development of the cultural life of the Polish immigration of the 19-th century in the field of fiction, literary criticism, journalism, publishing and public activities were characterized as the theme of the January uprising determined the direction and problematics of the journalistic and public activities of the writer of the Dresden period of life and work. Peculiarities of creative rethinking of consequences of the Polish Insurrection of 1863 in the large-scale artistic heritage of Josef Ignacy Kraszewski, in particular, in the cycle of novels on political issues that were published under the pseudonym Bogdan Boleslavit “The Child of the Old City” (1863), “We and They” (1865), “Moscal” (1865), “The Jew” (1866), “Travelers “(1968-1970),” In a Strange Land “(1871). In the Dresden period the creativity of Josef Ignacy Kraszewski acquired new features – profound analytic and critical judiciousness of judgements. It should be noted the richness of the problematics and genre variety of the creative work of Kraszewski in this period.

The novel “In a Strange Land” contains abundance of social realities, emotional images of conflicts and characters of the work. The narrative strategy of the novel is determined by the emotionality, sensuality and high degree of the presence of the narrator in the work through the indirect representation of his personal feelings, ideas and the declaration of a personal social position

On the material of the novel “In a Strange Land” the motive of expulsion, martyrdom, involuntary journey, travel-escape is analyzed both in the literature of the mentioned period and in the narrative discourse of Josef Ignacy Kraszewski. The writer demonstrates the intersection of Polish and foreign culture from his own position of emigrant. The article analyzes the intricate mechanism of saving national identity in such political situation after January uprising
Intelectualidade e escritas de si
Authors: Fontineles Filho Pedro Pio
Published: December 2019

Resumo: O objetivo principal deste estudo é compreender os traços (auto)biográficos na obra do literato O. G. Rego de Carvalho (1930-2013). Metodologicamente, o estudo fez a leitura analítico-interpretativa do universo documental, que foi composto pelo livro Como e por que me fiz escritor (1994), de livros em forma de antologias e fortuna crítica sobre a obra do literato. Como arcabouço teórico-metodológico, foram utilizadas as proposições de Bourdieu (2010, 2006), Chartier (2002), Certeau (2011) e Lejeune (2008), para pensar o “campo literário”, a biografia e a autobiografia. O estudo considerou, em linhas gerais, que a obra do literato é fulcral para pensar os elementos dinâmicos da escrita (auto)biográfica.
Palavras-chave: literatura; (auto)biografia; escrita; leitura; O. G. Rego de Carvalho.
Assis Horta
Authors: Souza Eneida Maria de
Published: December 2019

Resumo: O fotógrafo profissional Assis Horta, natural de Diamantina, apresenta uma coleção de imagens de dimensão histórico-documental não só por ter registrado paisagens urbanas e humanas, mas por ter contribuído para a democratização do retrato no Brasil, adquirida por meio das leis trabalhistas. Reconhecida oficialmente em 1943 pela Consolidação das Leis do Trabalho no governo Vargas – com a aquisição da carteira de trabalho e Previdência Social –, a classe operária passa a ter seu registro em foto 3x4 (três por quatro) como prova de identidade. Com o fim da condição de invisibilidade social da classe, aos poucos é construída uma nova feição para a caracterização de povo e de cidadania no país. Na condição de um intérprete da sociedade pelo registro fotográfico, Assis Horta valoriza imagens do homem comum, registra cenas de família e contribui para o avanço dos estudos marginais sobre povo, nação e cidadania.
Palavras-chave: Assis Horta; Diamantina; fotografia; homem comum; povo; cidadania.
Naprawienie szkody spowodowanej ograniczeniem korzystania z nieruchomości w związku z ochroną przyrody – wybrane zagadnienia
Authors: Lebowa Dorota
Published: December 2019

Establishing legal forms of nature conservation entails a restriction on the right of ownership and other property rights. For this reason, the legislature introduced in the Act of 27 April 2001 on Environmental Protection Law solutions allowing for the purchase of real estate or payment of damages. The provisions of the Environmental Protection Law set out an administrative-judicial procedure of claiming for remedying a damage caused by the legal operation of the public administration related to the protection of environmental resources. This procedure is based on the fact that a claim, essentially of a civil nature (a claim for remedying a damage caused by restricting the use of property) is pursued in two stages – the first in an administrative proceeding in which the administrative authority issues a decision and in the second, where the case is decided by a general court. The first stage is obligatory, in the sense that in the event of a dispute for compensation, the aggrieved party must apply to the administrative body for compensation. The second is initiated as a result of the action of the party dissatisfied with the compensation awarded by the administrative body.
IRRIGAÇÃO COM ÁGUA TRATADA ELETROMAGNETICAMENTE: SOLUÇÃO PARA PRODUÇÃO DE TOMATE EM SOLOS SALINOS?
Authors: Souza A. V. , Furlaneto K. A , Santos J. A. , Vieira M. R. S. , Putti F. F.
Published: December 2019

Uma das principais plantas cultivadas em ambiente protegido é a cultura do tomate, o qual apresenta expressivo crescimento em sua demanda, por ser um fruto saboroso, rico em nutrientes, e de alto valor agregado, contudo, o mau manejo dos fertilizantes provoca o processo de salinização do solo, provocando diversas consequências, desde redução da produtividade até mesmo a infertilidade do solo. Tais fatos são oriundos do aumento da concentração de sais, o que dificulta o processo de absorção da água pela planta, acarretando no desbalanceamento bioquímico e nutricional na planta. Pesquisas recentes apontam que, quando a água é induzida ao campo eletromagnético, ocorre um processo físico que auxilia na polarização da água, reduzindo o número de clusters e auxiliando na dissolução de sais. Deste modo, o presente trabalho visou investigar os efeitos da água tratada eletromagneticamente e sem tratamento em solos salinizados nos parâmetros físico, físico-químicos e bioquímicos em frutos de tomate. O experimento foi conduzido na Faculdade de Ciências e Engenharia, Campus de Tupã (FCE/UNESP). Adotou-se o delineamento em blocos casualizados, com dois tipos de água tratada, cinco diferentes níveis de salinidade inicial (0; 1,5; 2,5; 4; 5,5; 7 dS m-1), por meio de fertirrigação. Apesar de evidentes os efeitos da salinidade nos parâmetros de qualidade dos frutos, não foram evidenciados efeitos benéficos no aumento ou manutenção da qualidade pós-colheita dos frutos cujas plantas foram tratadas com água eletromagnetizada.
Editorial
Authors: Betancourt De Arco Ramon
Published: December 2019

La Revista Cultural de la Universidad Libre sede Cartagena, como escenario para la manifestación de las diversas tendencias y circunstancias que rodean el derecho, la cultura, las artes, la sociedad, la economía, y observando las diversas anotaciones vinculadas con la presente edición, y referidas de manera particular al poder político y los derechos humanos frente a este, como también lo que nos recuerdan de Enrique Dussel1 en el presente número, nos llevan a elaborar un análisis de como el hemisferio se encuentra en expectativa por el desarrollo de los cambios en la forma de administrar un Estado en particular, lo cual genera repercusiones en la región en cuanto a lo social, económico, cultural y de manera especial en la geopolítica.
Derecho y Liberación Aproximación de los Usos Emancipatorios del Derecho al Interior de la Política de la Liberación de Enrique Dussel
Authors: Londoño Luis Daniel
Published: December 2019

El derecho planteado en términos de intervención es necesario hasta el punto de considerarse, desde el dolor de las víctimas, una opción necesaria y con capacidad para reivindicar los derechos humanos. La reivindicación de derechos humanos es una acción emancipatoria, teniendo en cuenta que la percepción generalizada de un modelo de sociedad se fundamenta en ciertos valores ideológicos que niegan la extensión de los derechos, valores que hemos interiorizado como si fueran verdades (p.e. “lo privado es mejor que lo público”, “el estado funciona peor que las empresas”, “el pez grande tiene derecho a comerse el pez pequeño”, “el ser humano es malo por naturaleza; por lo tanto el egoísmo es productivo”, “es mejor pensar en el bienestar propio y no en el bienestar colectivo”, entre otros).
Razonamiento y Racionalidad un Análisis Conceptual
Authors: Carrillo De La Rosa Yesid
Published: December 2019

El concepto de “razonamiento”, en tanto ob­jeto de análisis, puede concebirse o aludir a una actividad mental - procedimiento - como lo hacen las ciencias sociales - sicología- o puede interesarse sólo por el resultado de esa actividad mental, sin consideración a las con­diciones en que se ha elaborado y sólo fiján­dose en la forma como en él se han estable­cido las premisas o se han usado las reglas de inferencias y llegado a la conclusión, como en el caso de la lógica, la tópica o la retórica (Perelman, 1993). En este trabajo se usará el término razonamiento en este último sentido.
Bailes Eróticos en Menores, ¿Arraigo Cultural o un Problema Social?
Authors: Guerra Rico Jacqueline Cristina
Published: December 2019

El presente artículo sustenta que la erotización temprana es un tipo de violencia sexual que afecta a los menores y que cada vez es más frecuente en la sociedad. Actualmente es causada por diversas razones, y una de éstas es por medio de bailes eróticos. Esta violación a la inocencia genera consecuencias como los embarazos en menores, degradación del concepto de la infancia, el ciclo vicioso de la pobreza, entre otros. Existen artículos constitucionales y legislativos, que afirman que éstos bailes atentan contra derechos fundamentales tales como el desarrollo integral del menor.
Este "negócio" é polissemia ou homonímia?
Authors: Gritti Letícia Lemos , Dos Santos Sandra Mara Fernandes , Teixeira Lovania Roehrig , Deon Robson
Published: December 2019

Este artigo, a partir de um ponto de vista semântico, analisa o item lexical 'negócio' usado em diferentes contextos no Português Brasileiro, desde os mais formais até os mais informais. Analisam-se as características do item, utilizando o conceito de ambiguidade. Tal fenômeno diz respeito à capacidade múltipla de significado que uma mesma palavra pode ter em determinados contextos. Mais especificamente, o estudo procura esclarecer se a ambiguidade lexical da palavra negócio é gerada por polissemia e/ou homonímia, dois tipos particulares de ambiguidade. As principais concepções teóricas são de Ilari e Geraldi (1987), Ilari (2002), Cambrussi e Poll (2015), Ferraz (2014), Pustejovsky, (1995) e Lyons (1977). Após análises, verificou-se que a palavra 'negócio' pode tanto apresentar usos em que apresenta ambiguidade por polissemia quanto ambiguidade por homonímia. Até onde se pode verificar, esse tipo de análise de 'negócio' é inédito na literatura linguística.
Proposta de dicionário de sinônimos para locuções adverbiais e prepositivas na direção português italiano
Authors: Bertonha Fábio Henrique de Carvalho , Zavaglia Claudia
Published: December 2019

Este artigo analisa locuções adverbiais e prepositivas compostas por ‘a’, ‘de’ e ‘em’ que contribuíram para a formulação de nosso dicionário especial na direção português-italiano, da macro à microestrutura. Apoiados em Lyons (1977), Tamba-Mecz (2006) e Regueiro Rodríguez (2013), acreditamos que duas ou mais palavras podem ser consideradas como sinônimas em uma língua se forem intercambiáveis em um dado contexto, sem provocar alteração de sentido, em outro. Visto que assumimos a equivalência entre as línguas como condição sine qua non para a elaboração de dicionários bilíngues, delineamos um verbete-modelo, que inclui contextos de uso a fim de atestar a ocorrência das locuções deste estudo. Legitimamos o uso da(s) locução(ões) equivalente(s) por meio de motores de busca na internet. Desse modo, verificamos a correspondência das ocorrências sinonímicas, ou melhor, se os contextos de uso na língua-fonte e na língua-alvo eram os mesmos. Nossos resultados demonstraram a presença de locuções adverbiais e prepositivas bem como a recorrência de advérbios terminados em ‘-mente’ como equivalentes sinonímicos, tanto em português quanto em italiano (ambos, inter- e intralinguisticamente). Com isso, destacamos a importância da sinonímia como fenômeno linguístico, especialmente, para tradutores, pois pode conduzi-los a equivalentes mais apropriados para um contexto particular.