bluuebunny/crossref_metadata_2025 huggingface dataset:
CT radiomics for evaluation of intervertebral disc change in the scoliosis
Authors: Fang Yuqi , He Yun
Published: February 2025

Background

Advanced methods are still lacking for the computed tomography (CT) evaluation of early degenerative changes of intervertebral disc in scoliosis.

Purpose

To investigate the feasibility of CT radiomics in evaluating early disc degeneration changes in scoliosis.

Material and Methods

A total of 60 patients with severe scoliosis were assessed with the method of CT radiomics. CT radiomics features of the intervertebral disc were obtained by using the software of 3D Slicer and were then compared between vertex disc (VD) and normal disc (ND). The analysis of maximum correlation minimum redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) regression method was used to establish a model. The receiver operating characteristic (ROC) curve was used to determine the performance of the model.

Results

ND and VD differed in 23 radiomics features ( P < 0.05). By using mRMR and LASSO methods, five features were finally selected to establish a model. The AUC of the model in the identification of VD were 0.93 and 0.90 for the training cohort and validation cohort, respectively. The sensitivity and specificity of the model were 90% and 85%, respectively.

Conclusion

CT radiomics of the intervertebral disc is feasible in identifying early degenerative changes caused by scoliosis.
True Blu
Authors: Barr Vilma
Published: February 2025

The Radisson Blu Minneapolis leverages Scandinavia's influence on the city
Notes on architectural lighting—II
Authors: Dinneen Ralph E.
Published: February 2025

Gargoyles, downspouts, the torus and scotia, cornice and entablature—all are ornamental devices of architecture. They define the appearance of a building, as well as its surfaces: the daylight enhances their interplay
Toward an Intersectional Theory of Practice: Integrating Pierre Bourdieu’s and Patricia H. Collins’s Thought
Authors: Romero-Moreno Aran
Published: February 2025

The article pursues three main objectives. First, I review and clarify the core philosophical foundations of Pierre Bourdieu’s theory of practice and Patricia H. Collins’s intersectional theory. Second, I examine the proximity of these two epistemological frameworks by comparing them with concrete references and practical examples. Finally, I investigate the synergistic possibilities of integrating the two political theories, highlighting conceptual and methodological gaps that further integration could address. This comparative analysis provides the groundwork for effectively developing an intersectional theory of practice.
Use of Hidden Markov Models to Identify Behavioral Patterns in Accelerometry Data of Subterranean Rodents in Field Enclosures
Authors: Jannetti Milene G. , Valentinuzzi Veronica S. , Oda Gisele A.
Published: February 2025

Activity rhythms of laboratory rodents are usually measured by running wheels, and although wheel running activity-or-rest data enable straightforward rhythmic analyses, it provides limited behavioral information. In subterranean rodents (tuco-tucos), we used bio-loggers (accelerometers) to measure activity rhythms in both lab and field conditions, detecting diverse movements that compose activity. However, understanding these different accelerometer-detected activity components requires more complex analytical tools. Here we used supervised hidden Markov models (HMMs) as a machine learning analysis, to identify behavioral patterns in accelerometer data of tuco-tucos from field enclosures and characterize their behavioral rhythms in this condition. Activity of tuco-tucos was previously video-recorded in the laboratory with simultaneous accelerometer measurements. Video-obtained behavioral data were used in HMM models to refine (train) the classification of accelerometer recordings into different behavioral states. The classification obtained by HMM matched in 93% the one obtained by the video-observed method. Trained models were then used to automatically extract behavior information from accelerometers attached to 20 unobserved tuco-tucos first maintained in field enclosures and then transferred to the laboratory. Activity bouts associated with digging and locomotion were responsible for the diurnal rhythm in field enclosures and the nocturnal rhythm in the laboratory. Bouts of activity spread throughout day and night (cathemeral) were present in both conditions and were associated with feeding, coprophagy, and grooming. Finally, while rest occurs throughout day and night in the laboratory setting, tuco-tucos restrict rest episodes to nighttime under field enclosures, possibly as a behavioral adjustment to challenging environments. HMM models provide more behavioral information from accelerometry data, expanding the scope of activity pattern studies in small mammals under natural conditions.
Systematic Search and Evaluation of mobile Apps for Wound Care Available in French-Language in Canada
Authors: Gagnon Julie , Chartrand Julie , Probst Sebastian , Maillet Éric , Reynolds Emily , Chaplain Valérie , St-Jean Heidi , East Raphaelle , Lalonde Michelle
Published: February 2025

Background

Wounds are a significant national health concern, impacting individuals, healthcare systems, and the environment. Despite efforts by organizations to promote evidence-based practices, gaps persist between theory and nurse practice in wound care. Mobile apps show promises in enhancing wound care delivery, but their rapid evolution, including adaptations into different languages such as French, raises concerns about reliability and regulation. Evaluating these apps is crucial for ensuring patient safety and effective wound management.

Purpose

To review and assess mobile wound care apps available in French for healthcare providers in Canada.

Methods

A systematic search was conducted across the literature and the two main Canadian online app stores (App Store and Google Play). The included mobile apps underwent quality evaluation using the user version of the Mobile Application Rating Scale (uMARS).

Results

The initial search retrieved 1,550 apps, of which 260 were screened and 5 included. Included apps were from France and were available on both stores. These apps varied in features, including wound dressing directory ( n = 3), best practices reminders ( n = 2), photography management and digital wound tracking ( n = 1), and total body surface area calculator ( n = 1). Evaluation using uMARS indicated total averages range from 3.52/5 to 4.10/5. The results offer scant insight into the design and evaluation of the apps included.

Conclusions

The study highlights the need for development and validation of a French wound care app tailored to Canadian healthcare contexts and best practice recommendations, emphasizing collaboration among nurses and stakeholders in technology enhancement for the benefit of Canadians’ health.
Thalamic Volume Reduction in Cerebral Visual Impairment: Relationship to Visual Dysfunction
Authors: Drottar Marie , Kim Chan-Mi , Nadvar Negin , Cabral Howard J , Bauer Corinna M
Published: February 2025

The thalamus is critical for the relay and modulation of visual information. As such, injury to the developing thalamus may result in cerebral visual impairment (CVI). This study investigated quantitative volume reductions of the thalamus in cerebral visual impairment compared to controls and probed the association between thalamic volume and the severity of cerebral visual impairment–related visual dysfunctions. Thalamic volumes were quantified using T1-weighted magnetic resonance imaging (MRI) data from 23 participants with cerebral visual impairment and 42 controls. Nineteen participants with cerebral visual impairment also completed the CVI Questionnaire. Cerebral visual impairment was associated with significant volume reductions of the global thalami, anterior, lateral, and ventral thalamic regions, as well as several nuclei, particularly in those with cerebral visual impairment due to periventricular leukomalacia. Within the cerebral visual impairment group, smaller volumes of the right thalamus and lateral pulvinar were significantly associated with more reported difficulties moving through space. Together, these results provide empirical evidence supporting aberrant thalamic development as a potential mechanism underlying cerebral visual impairment.
Detention or Dissent: Judicial Utilization of Public Safety Assessments During Pretrial Detention Hearings in a New Jersey Courtroom
Authors: Torres Luis C. , Vaughn Paige E. , Williams Joshua H.
Published: February 2025

This study examines how the Public Safety Assessment (PSA), a type of risk assessment tool employed to assist with pretrial decision-making, is utilized during virtual detention hearings in New Jersey. Drawing on observational data from a single courtroom ( N = 330), we (a) describe judicial departures from PSA recommendations, (b) employ logistic regression models to assess the factors predicting departures, and (c) explore the reasons provided by judges for departures. The findings show that departures from PSAs are common and that most defendants are either detained or released under the most restrictive monitoring conditions, even in cases involving defendants considered to be lower risk. Moreover, and consistent with focal concerns, factors signaling a defendant’s dangerousness (e.g., current monitoring status and number of alleged offenses) predict departures. Overall, our findings suggest that judicial discretionary power continues to play a role in the courtroom.
Feminist ethic of care in academic knowledge production: Reflections from disability researchers
Authors: López Radrigán Constanza , Aparicio Andrés , Tenorio Marcela
Published: February 2025

Drawing from the experiences of researchers associated with feminist disability studies, this article reflects on care as an ethical foundation in the processes of academic knowledge production. In a qualitative study using a constructivist grounded theory approach, we analysed interviews and identified key points of reflection that reveal interactions aimed at building communities and alliances within and beyond academia. A model of thinking about care as an ethic oriented towards reshaping the relationships with participants in academic studies is advanced. In this context, certain feminist research practices are highlighted, aimed at redistributing power in these processes.
Violence facing nurses and the threats they pose to autonomy and justice
Authors: Chackal Tony , Mitchell Cassandra
Published: February 2025

Nurses experience various types of violence in healthcare. This violence can be perpetrated by doctors, other nurses, patients, and their families, as well as other members of the healthcare team. While traditionally thought of as physical, violence may also be non-physical, that is, verbal, emotional, and psychological in nature. In this paper, we outline three categories of violence experienced by nurses: vertical, lateral, and angular. When violence occurs by someone in a position of authority like physicians, it is vertical, when occurring by someone in an equal position like other nurses, it is lateral, and when violence occurs by someone in an adjacent position like patients, it is angular. Violence may carry violations of autonomy and justice for nurses. Autonomy and justice are two principles of healthcare ethics, which have traditionally been applied primarily to patients. We expand the application of these principles to healthcare workers and highlight how violence obstructs autonomy and justice for nurses. Some instances of violence obstruct autonomy by undermining nurses’ everyday decision-making while aggregate violence obstructs autonomy by causing some to leave the field altogether. Some instances of violence violate justice by undermining nurses’ epistemic capacities while others concern unfairness produced by unjust distributions of resources.
‘It is a grey area in sport, not just in school’: A figurational analysis of banter in secondary physical education in England
Authors: Green Matthew J , Mierzwinski Mark F
Published: February 2025

This article provides a figurational sociological analysis of how secondary school pupils and teachers perceived, manifested and determined (in)appropriate banter in Physical Education (PE). Generated through lesson observations, pupil focus groups and teacher interviews, ethnographic data is thematically analysed and interpreted through Elias's concepts of figuration and individual civilising process. Banter was increasingly normalised and legitimised amongst most older pupils, who often enjoyed banter's motivating and competitive functions. Such productive functions were deemed appropriate, whilst judgements on inappropriate banter were fluid, relationally dependent and emotion-laden. Within a PE figuration centred on sociality, competitiveness and performance-related commentary, to successfully understand, engage in and navigate (in)appropriate banter, older pupils embodied cognitive foresight, social awareness and emotional intelligence. Given these qualities, social constructions of appropriateness and policy-based concerns regarding inappropriateness, we recommend educators/pupils and coaches/players develop a localised shared understanding of appropriate banter and an agreed mechanism to report inappropriate banter.
A Commentary on Asmuß and Thomsen’s (2024) “Relational Perspective of Inclusion”
Authors: Ayinaddis Samuel Godadaw
Published: February 2025

The purpose of this commentary piece is to advance the scholarly discourse on Asmuß and Thomsen’s original research on how relational practices in social partnerships could create a workplace inclusion opportunity for people with intellectual disabilities. The main contribution of this study is the shift in focus from an institutional, hierarchical view of inclusion towards a relational approach that focuses on building communicative interactions at the micro level among different stakeholders. This commentary is, therefore, generally enthusiastic; it reflects on the focal article, discuss their broader implications for the field, and suggests complimentary theoretical lens to further strengthening the discourse on fostering inclusive practices in diverse environments.
Trust in Government or in Technology? What Really Drives Internet Voting
Authors: Abdala M. Belén , Plescia Carolina , Boyer Ming M. , Brunetti Anna Lia
Published: February 2025

Internet voting is considered a crucial potential technological innovation, and scholars agree that trust plays a key role for its adoption and use by citizens. But which type of trust is essential, trust in government or trust in technology? We leverage on a cross-sectional analysis and a preregistered online experiment in Estonia to test a multidimensional trust framework. Examining the impact of trust dimensions on i-voting likelihood, we unveil a robust correlation between trust in government and in i-voting technology. While both elicit the intention to i-vote, trust in technology emerges as a stronger driver for the decision between online or in-person voting. These findings significantly contribute to comprehending i-voting and offer insights into the practical implementation of technology in democratic processes.
Broadband sound-absorption of absorbing panel based on Helmholtz and coiled chamber
Authors: Han Lei , Ji Hongli , Wang Xiaodong , Jiang Yi
Published: February 2025

A subwavelength sound-absorbing panel composed of an extended-neck Helmholtz resonator and a coiled coplanar chamber is presented. The coiled coplanar chamber acts as the backplane of the Helmholtz resonator to produce additional absorption peaks. A theoretical model is developed and a numerical simulation is performed to predict the sound absorption coefficient of the proposed absorbing panel and reveal its physical absorption mechanism. An investigation is also conducted on how the structural parameters of the absorbing panel affect its absorption characteristics. The results demonstrate that appropriately adjusting the structural parameters can yield efficient sound absorption for low-frequency sounds throughout a broad range by employing several units connected in parallel mode. The numerical simulation shows that the energy of incoming sound waves is primarily dissipated through the extended neck and coiled chamber. To confirm the validity of the theoretical model and numerical simulation, an experimental study is conducted to evaluate the acoustic characteristics of the designed samples.
Unraveling the Retweet Dynamics of COVID-19 Vaccines on Twitter: An Investigation Through the Lens of the Health Belief Model
Authors: Wu Yanfang
Published: February 2025

This study uses the Health Belief Model (HBM) to analyze the narrative constructions and sentiments of the most retweeted tweets about COVID-19 vaccines. Large-scale data and qualitative textual analysis revealed that tweet dissemination is influenced by perceived risks and benefits, while the tweet format (narrative vs. non-narrative) had no significant effect. Personal stories gained more shares than cultural stories, and high-benefit narratives received more retweets than low-risk ones. Tweets with highly perceived benefits elicited positive sentiments, highlighting implications for effective health communication on social media. Theoretical implications for the HBM model and crafting effective intervention health messages were discussed.
Daratumumab desensitization: Novel approaches in POEMS syndrome experience
Authors: Villarreal-González Rosalaura , Flores-García Nataly , Cadenas-García Diana , Gómez-De León Andrés , Piñeiro- Retif Rafael , Vidal-Gutiérrez Oscar
Published: February 2025

Daratumumab is a human IgG1κ monoclonal antibody targeting CD38, with infusion-related reactions occurring in 45–48% of patients. Among these, 5–10% are severe, requiring treatment discontinuation in 1% of cases. The incidence of hypersensitivity reactions (HSRs) to daratumumab is unknown. We describe a 37-year-old male diagnosed with POEMS syndrome and treated with autologous hematopoietic stem cell transplantation and chemotherapy. Presenting a relapse of the disease, intravenous daratumumab was initiated. Ten minutes after starting the first infusion, he presented with generalized rash, abdominal pain, vomiting, pharyngeal pruritus, throat tightness, dyspnea, decreased oxygen saturation, tachycardia and diaphoresis (Brown III). Due to the refractory disease and lack of alternatives, a desensitization protocol for daratumumab 1000 mg was implemented using a (3 bag-12 step) over 5.67 h. Eight successful desensitizations were performed without hypersensitivity reactions, enabling safe drug reintroduction. Currently, only one successful daratumumab desensitization protocol has been published, involving a 4-bag, 14-step procedure over 5.2 h, as reported by Carrón-Herrero et al. Prior to desensitization, the patient experienced flushing, pharyngeal pruritus, bronchospasm, dyspnea, desaturation, bradycardia, and hypotension. Both case reports were associated with severe anaphylaxis, ultimately enabling the safe reintroduction of the drug.
Initial real-world experience with ribociclib in advanced breast cancer
Authors: Nawaz Azhar , Zekri Jamal , Rasool Haleem , Ibrahim Refaei
Published: February 2025

Purpose

CDK4/6 inhibitors, such as ribociclib, are recommended in combination with hormonal therapy to treat advanced/metastatic hormone receptor-positive, HER2-negative breast cancer. The objectives of this study are to evaluate the therapeutic outcome and tolerance of ribociclib in patients treated at our institution.

Methods

The initial cohort of patients who received >1 cycle of ribociclib between December 2018 and March 2022 were included. Rates of adverse events (AEs) related dose reduction and discontinuation of ribociclib were used as a surrogate marker for intolerance.

Results

Sixty-eight female patients were included. Ribociclib was administered with letrozole or fulvestrant in the first-, second-, third-, and fourth-line palliative hormonal therapy settings in 29 (42.6%), 26 (38.2%), 12 (17.6%) and 1 (1.5%) patients respectively. Adverse events (AEs) related dose reduction was reported in 30 (44%) patients. Ribociclib was permanently discontinued in 42/68 (61.8%) patients [Disease progression 33/68 (48.5%) and AEs 9 (13.2%)]. Objective response was documented in 10/61 (16.4%) evaluable patients. The median progression free survival (PFS) was 18 months (95% CI: 11.7–24.3). The median overall survival (OS) was not reached and 84% of patients were alive at 3 years.

Conclusions

Although objective response rates were modest in this mixed cohort of heavily pretreated patients, ribociclib combined with letrozole or fulvestrant has shown robust PFS and OS in real-world practice. AEs related treatment discontinuation rate is higher than that reported in clinical trials with stringent inclusion criteria.
Content Analysis of the Portrayal of Prescription Stimulants on TikTok
Authors: Johnson Benjamin , Sun Tianze , Wu Leo , Seal Stella , Stjepanovic Daniel , Chan Gary , Leung Janni
Published: February 2025

Background:

TikTok has become a significant influence on public health perceptions, especially regarding ADHD. With its expansive reach among younger demographics, TikTok content has the potential to shape public understanding and behaviors related to ADHD treatment. This study analyzed how prescription stimulants are depicted on TikTok to assess the potential influence of these portrayals on ADHD stimulant medication demand.

Methods:

We employed a snowball sampling strategy to collect 1,000 TikTok videos related to prescription stimulants. A systematic content analysis was conducted on a refined dataset of 548 videos, identifying primary categories related to prescription stimulant portrayals.

Results:

The videos, which predominantly featured young adults, mainly white and female, amassed an average of over 300,000 views per video. Our analysis uncovered four primary categories: Positive Effects, Negative Effects, Context of Use, and Systemic Challenges. Videos frequently depicted substantial improvements in daily functionality and emotional well-being attributed to prescription stimulants, with side effects presented as manageable. The context of use highlighted the broad applications of these medications in daily life, while systemic challenges focused on issues such as healthcare barriers, medication shortages, and stigma.

Conclusion:

TikTok users’ portrayal of prescription stimulants were predominantly positive, emphasizing improved lifestyles, which may influence medication demand similar to direct-to-consumer advertising, particularly among young women. The depiction of systemic barriers underscores the complexity of accessing treatment, which may disproportionately affect individuals with ADHD and impact treatment adherence, warranting further research into audience reception of this content.
Quantitative ultrasound analysis for non-invasive assessment of hepatic steatosis in metabolic dysfunction-associated steatotic liver disease
Authors: Fan Yunling , Chen Kailing , Zhao Qiannan , Yin Haohao , Zhu Yuli , Xu Huixiong
Published: February 2025

Objective

To evaluate the diagnostic performance of novel tissue attenuation imaging (TAI) and tissue scatter distribution imaging (TSI) tools in detecting and grading hepatic steatosis using controlled attenuation parameter (CAP) as reference standard.

Methods

A total of 185 participants with suspected metabolic dysfunction-associated steatotic liver disease (MASLD) were prospectively enrolled, and all underwent CAP and quantitative ultrasound (QUS) testing. Correlations between CAP, biological data, TAI and TSI were assessed. The influence factors of TAI and TSI as well as the diagnostic performance of TAI and TSI in detecting hepatic steatosis were evaluated.

Results

The QUS parameters (TAI and TSI) showed good intra-observer reliability with ICC of 0.972 and 0.777, respectively. The correlation of CAP with TAI was higher than that of TSI (0.724 vs 0.360, P < 0.05). Multivariate Regression analysis showed that CAP was an important influence factor of TAI and TSI ( P < 0.001). The area under the ROC curve (CAP > 250 dB/m) of TAI and TSI tools for detecting hepatic steatosis was 0.876 (95% CI: 0.813–0.923; P < 0.0001) and 0.797(95% CI: 0.724–0.857; P < 0.001), respectively; the sensitivity was 67.18% and 83.21%, the specificity was 95.65% and 69.57%, and the cut-off values were 0.93 dB/cm/MHz and 91.28, respectively. When TAI and TSI were combined, the area under the ROC curve was 0.881, with a sensitivity of 80.92% and a specificity of 82.61%. The Delong test showed that the combined diagnosis of TAI and TSI was equivalent to the use of TAI alone ( P > 0.05).

Conclusion

TAI and TSI provided good intra-observer reliability, correlated well with CAP, and helped to detect and stage hepatic steatosis.
Teaching and learning indigenous languages: An Atayal book project
Authors: Hsin Ching-Ting , Hsieh Ming-Fang , Tsao Ya-Lun , Chang Wan-Chen , Compton-Lilly Catherine
Published: February 2025

This study drew on two case studies to explore the implementation of the Atayal Indigenous book program in Taiwan. Eight teachers from two focal classrooms were invited to use dual language books featuring recurring grammatical structures to help young children learn the Atayal language. This study’s purpose was to explore the instructional strategies teachers used and the contribution of the book project to children’s Atayal language learning. The teachers were interviewed and asked to videotape the Atayal lessons conducted using the books. Pre- and post-tests were conducted to assess children’s Atayal language learning, particularly for the language presented in the books. Qualitative and quantitative analyses (i.e., Wilcoxon signed-rank and Chi-square tests) were performed. The findings suggest that the teachers in both focal classrooms used multiple strategies to successfully promote children’s learning of Atayal vocabulary, sentences, and cultural practices. The findings indicated an interplay between instructional strategies and children’s Atayal language learning, with practices extending beyond teaching vocabulary being particularly beneficial. Thus, teacher expertise can affect language learning and the instructional strategies that teachers use to support young children’s Atayal language acquisition.
Fractal characteristics of micropore structure of Taiyuan Formation bauxite reservoir in Longdong area of Ordos Basin
Authors: Dong Yue , Yang Xiaochen , Hu Chenguanng , Zhou Jiang , Li Yongjin , Qin Qin , Yin Zhaoyang , Li Haoyuan , Zhu Yushuang
Published: February 2025

As an unconventional gas reservoir, bauxite gas reservoirs have often been studied as weathered crust cover layers rather than reservoirs in the past. The Taiyuan Formation bauxite in the Longdong area of the Ordos Basin has achieved breakthroughs, and some wells have obtained industrial airflow. Therefore, it is necessary to conduct basic geological research on the bauxite reservoir. The application of casting thin sections, scanning electron microscopy (SEM), X-ray diffraction (XRD), high-pressure mercury injection (HPMI), and low-temperature nitrogen adsorption (L-TNA) techniques provides a comprehensive framework for studying reservoir characteristics as well as the micropore fractal structure. The results indicate that (1) the bauxite reservoir has logging characteristics of high natural gamma (500API) and low acoustic wave time difference (60–90 us/m), with natural gamma being the most critical parameter in identifying the bauxite reservoir in the logging curve. (2) The bauxite rocks in the Longdong region belong to sedimentary formation, and three types of micro ancient landforms (buried pits, terraces, and grooves) have different lithological combinations. Among them, the combination of the bauxite rocks in the buried pits and carbonaceous mudstones has been subjected to freshwater leaching for a long time, and the thickness of the bauxite rocks is the largest. (3) The pores of bauxite reservoir are mainly dissolution pores within particles, intergranular dissolution pores, intergranular pores, and microcracks. The average porosity of the reservoir is 8.49%, and the average permeability is 0.261 × 10−3 μm2, with a low permeability standard greater than 0.4 accounting for 17.19%. (4) The fractal dimension D2 of micropore D1 and nanopore D2 were calculated by high-pressure mercury injection and nitrogen adsorption experiments, respectively. Through correlation analysis, we found that the fractal dimension D2 (calculated from nitrogen adsorption data) more effectively characterizes the comprehensive quality of nanopores within the bauxite reservoir compared to the fractal dimension D1 obtained from high-pressure mercury injection (HPMI). We have established classification evaluation standards: Type I D1 is 2.2∼2.6, Type II D1 is 2.6∼2.8, and Type III D1 is 2.8∼3. Among them, Class I bauxite reservoir is a high-quality reservoir and can be the preferred target for exploration in the study area.
Play during the pandemic
Authors: Burroughs Sophia , Minneman Cameron , Neeper Sarah , O’Shaughnessy Gabrielle , Schnabel Madeline , Schmelzer Laura , Metz Alexia E.
Published: February 2025

Play is an integral part of childhood which is done for the sake of enjoyment but also confers many benefits. For young children who attend childcare, preschool, and elementary school, play is frequently done outside the home and with peers. The public health measures of the COVID-19 pandemic confined many families to their homes while parents had to continue to meet demands of work and home responsibilities. We surveyed ( n = 175) and interviewed ( n = 62) a convenience sample of parents of young children (aged 1–8) in the USA about how their children’s play was affected. Parents shared concerns that their children missed opportunities for social play. Parents reported novel efforts to facilitate their children’s play, including rearranging furniture, repurposing spaces, and providing new toys. While at home, children’s play increased in every room of the house; they played more with family members; and their preference for technology toys increased from an already high rank. Play times shifted toward earlier in the day. Parents reported that play activities included physical activity, seated play, screen time, and creative activities. In interview, parents observed that the content of play reflected themes of the pandemic (such as mask-wearing) and a desire for normalcy (such as playing school).
Transcriptional Regulation of NUPR1 by MYH11 Activates PI3 K/AKT and Promotes Bladder Cancer Progression Through Ferroptosis and M2 Polarization of Macrophages
Authors: Zhang Lifeng , Zhang Li , Shi Zebin , Mi Yuanyuan , Zhang Lei , Shi Xiaokai , Gao Shenglin , Zuo Li
Published: February 2025

Background

NUPR1 is a small molecule protein that plays an important role in tumor progression and drug resistance. Our previous study found that NUPR1 promotes the progression of bladder cancer, but the specific mechanism is still unclear. MYH11 encodes the smooth muscle myosin heavy chain and belongs to the conventional myosin family. MYH11 has been found to be associated with a variety of malignant tumors.

Methods

We identified MYH11 as an upstream regulator of NUPR1 using a bioinformatics approach and tested this hypothesis by knocking down MYH11 and ChIP-qPCR. Subsequently, we verified the association of MYH11 and NUPR1 with the PI3 K/AKT pathway by WB. In addition, gene enrichment results showed that the effect of NUPR1 on bladder cancer was related to ferroptosis and M2 macrophage polarization. We examined ferroptosis metabolites in bladder cancer cells overexpressing NUPR1 and expression of the M2 macrophage marker CD206 in NUPR1 overexpression or MYH11 knockdown bladder cancer cells.

Results

Bioinformatics results showed that MYH11 was positively correlated with NUPR1, and there may be a mutual binding site at the promoter of NUPR1. Knockdown of MYH11 decreased NUPR1 expression, and ChIP-qPCR showed that MYH11 bound to the promoter of NUPR1. Subsequently, WB results showed that MYH11 knockdown inhibited the PI3 K/AKT pathway, whereas NUPR1 overexpression activated this pathway. After adding ferroptosis activator, the viability of bladder cancer cells decreased, and the content of Fe2+ and MDA increased. However, ferroptosis was significantly inhibited after overexpression of NUPR1. Knockdown of MYH11 inhibited M2 macrophage polarization, while overexpression of NUPR1 promoted this process.

Conclusion

This study suggests that MYH11 activates the PI3 K/AKT pathway by up-regulating the expression of NUPR1, and promotes bladder cancer progression by inhibiting ferroptosis and promoting M2 polarization of macrophages.
The Hidden Toll of Grief After Youth Gun Violence
Authors: Gross Nora
Published: February 2025

Ethnographic research at an all-Black, all-boys high school uncovers the emotional and academic toll of young men’s untended grief in the wake of gun deaths. After the balloons are released and the candles are snuffed out, public vigils become private burdens for the youth who survive their peers.
The Power of Partiality
Authors: Pugh Allison J.
Published: February 2025

Allison J. Pugh on the lamentable triumph of objective knowledge.
Dasatinib-induced renal (or chronic) thrombotic microangiopathy in a patient with chronic myeloid leukemia: A case report
Authors: Sabour Ryan , Kharabaf Sohrab , Frazier Eric , Nguyen Matthew , Le Dao , Zuckerman Jonathan , Hanna Ramy
Published: February 2025

Thrombotic microangiopathy encompasses microvascular thrombosis, hemolytic anemia, thrombocytopenia, and end-organ damage. Secondary thrombotic microangiopathy can result from malignancies, autoimmune diseases, or treatments such as tyrosine kinase inhibitors. Dasatinib, a tyrosine kinase inhibitor used in managing chronic myeloid leukemia, has been linked to thrombotic microangiopathy. This report describes a 66-year-old female with chronic myeloid leukemia treated with dasatinib who developed renal-limited thrombotic microangiopathy. Progressive renal dysfunction found in the context of chronic kidney disease prompted extensive lab evaluation and evaluation, with a renal biopsy confirming thrombotic microangiopathy attributed to dasatinib-induced nephrotoxicity. Discontinuation of dasatinib led to a slight improvement in renal function; however, progressive decline necessitated dialysis. This case underscores the diagnostic and therapeutic challenges of dasatinib-induced thrombotic microangiopathy, emphasizing renal biopsy in diagnosis and monitoring. Individualized treatment strategies and further research should be conducted to optimize future outcomes.
An exploration of science popularization ethics in China facing the future: Completing an important part of the ethical governance of science and technology
Authors: Ren Peng , Ren Dingcheng
Published: February 2025

Science popularization (SP) ethics is an indispensable part of the ethical governance of science and technology (S&T). This paper discusses the necessity of developing science popularization ethics in China in the new era and their important role in the construction of the future S&T ethics governance system. We analyse the main problems and challenges facing SP ethics in China and the practice and enlightenment of SP ethics from Western countries. Based on this analysis, we put forward construction strategies and implementation paths for SP ethics in China, aiming to provide support for the improvement of the S&T ethics governance system and complete an important part of that system. By strengthening the construction of SP ethics, we can more effectively promote the social responsibility of S&T achievements, improve the public's understanding and acceptance of science and realize the harmonious integration of S&T and society, thus providing moral guidance and ethical guarantees for China's S&T progress and social development.
Current Methods Used to Evaluate Glenoid Bone Loss: A Survey of Orthopaedic Surgeons
Authors: Huddleston Hailey , Credille Kevin , Wang Zachary , Cregar William , Lansdown Drew Anderson , Chahla Jorge , Garrigues Grant E. , Verma Nikhil N. , Yanke Adam B.
Published: February 2025

Background:

Evaluation of glenoid bone loss is critical in preoperative planning, as bone loss >13.5% has been associated with worse clinical outcomes. While 3‐dimensional computed tomography (3D CT) and the Pico method have been the gold standard in bone loss evaluation, it is unclear how most orthopaedic surgeons evaluate for bone loss in practice.

Purpose:

To investigate the techniques used by orthopaedic surgeons to measure glenoid bone loss.

Study Design:

Cross-sectional study.

Methods:

A 12‐question survey was sent to members of the AOSSM and Arthroscopy Association of North America. This survey included questions regarding the participants’ demographic information, typical surgical practice and volume, and glenoid bone loss identification method. Friedman testing with multiple comparisons using Bonferroni correction was used to evaluate the ordinal variable, use frequency, while Kruskal-Wallis testing and Spearman correlations were used to evaluate the role of surgeon demographic factors on method usage.

Results:

Overall, 171 orthopaedic surgeons responded to the survey. Participating surgeons were from a variety of locations, practice settings, and years in practice; 91.1% of respondents said that they routinely measure glenoid bone loss. The imaging modality most commonly used for bone loss evaluation was 3D CT, followed by 2‐dimensional (2D) magnetic resonance imaging, then 2D CT and radiographs. Percentage diameter loss was the most commonly used method of bone loss evaluation. The intraoperative probe length method was used occasionally, the Pico method was used rarely, and the chord length method was never used. There was no significant effect of time in practice or practice location on bone loss methods used. Surgeons in private practice ( P = .022) or other settings ( P = .015) had a higher frequency of using the intraoperative probe length method compared with those in the military.

Conclusion:

Overall, this study highlights the inconsistency in surgeon evaluation of glenoid bone loss in shoulder instability, despite good evidence of its clinical importance, especially in preventing recurrent instability. This lack of consistency may be mitigated with the establishment of best practice guidelines or accepted algorithms for evaluation and assessment of glenoid bone loss in shoulder instability.
Indonesian Nursing Students’ Perceptions of Caring in Clinical Setting: A Descriptive Qualitative Study
Authors: Mariyanti Herdina , Yeo Kee Jiar , Klankhajhon Sirikanok , Arifin Hidayat
Published: February 2025

Background

Clinical education is crucial in nursing programs for preparing students to deliver compassionate, high-quality care. However, research on nursing students’ perceptions and expressions of caring behaviors in clinical settings is limited, particularly in Indonesia. This study aims to explore Indonesian nursing students’ views on caring behaviors in clinical settings, addressing a significant gap in nursing education research within the Indonesian context.

Methods

A descriptive phenomenology research design was employed in this study. Nursing students’ views and perceptions of caring were obtained through telephone interviews with semistructured questions. The research participants comprised 20 undergraduate nursing students undergoing clinical education at nursing education institutions in Surabaya, Indonesia, obtained through purposive sampling. The recorded interviews were transcribed and analyzed using a phenomenological method. To ensure reliability and validity in the data analysis process, grounded in Husserlian phenomenology and Giorgi's phenomenological method were employed.

Results

Seven key themes related to the perceptions of caring behavior emerged from the phenomenological analysis: (1) Caring as trying one's best to meet patients’ needs; (2) Caring as a central value of nursing practice; (3) Caring as compassion; (4) Caring as helping each other; (5) Caring as awareness of patients’ individual needs; (6) Caring as professionalism; and (7) Caring as support.

Conclusion

The findings of this study are expected to significantly improve nursing student application of caring behavior in the clinical setting. Increasing understanding and application of caring behavior in nursing students can have a positive impact on clinical practice. This study is useful as a guide for educators to help nursing students improve their caring practice in the clinical setting.
Taming Ostial LAD Ambiguous Cap CTO
Authors: Annam Sharath Reddy , Krishna Anil , Lokanath  , Sridhar P. , Balaji R. , Premchand
Published: February 2025

Chronic total occlusion (CTO) percutaneous coronary interventions have more complications due to intrinsic complexity of procedure which is further compounded by ambiguity of proximal cap. If the ambiguous proximal cap CTO is at ostial left anterior descending artery (LAD), impact of complications is huge as the area of myocardium at risk is significant. Hence, while treating ambiguous proximal cap CTO at ostial LAD or left circumflex artery (LCX), special attention must be given to prevent or minimize inflow injuries like dissection or intramural hematoma (IMH) of left main coronary artery (LMCA) and its branches. In order to prevent such complications, all the available CTO techniques need to be understood in this context and executed to keep procedural outcomes as predictable as possible. Intravascular ultrasound (IVUS) imaging is the passkey in wiring and detecting inflow injury to prevent intraprocedural catastrophes. This article explores the refinement and modification of existing techniques of CTO PCI and the use of imaging in the context of ostial LAD CTO PCI.
Vancomycin Resistance Streptococcus pneumoniae, a Case Report
Authors: Najmadden Zana Baqi , Salih Khalid Hama , Hama Jihad Ibrahim , Kakamad Fahmi Hussein , Khurshid Bakhtyar Qadr Hama
Published: February 2025

Streptococcus pneumoniae is a pathogenic bacterium that causes invasive pneumococcal disease in humans, especially pediatric patients. Antibiotics are primary therapeutic agents. Resistance to antibiotics is a growing health problem, and healthcare authorities have warned that 10 million people will die each year by 2050 and become the first killer. To date, resistance to vancomycin has not been recorded in Iraq. This study reports a 9-month-old infant presented with fever, irritability, crying, and decreased oral intake for 3 days. Cerebrospinal fluid (CSF) parameters included turbid appearance, pleocytosis, and high protein and low sugar levels. Culture and sensitivity tests revealed the growth of Streptococcus pneumoniae, which is resistant to vancomycin. Reporting vancomycin resistance in Streptococcus pneumonia adds to the growing body of research on the pandemic of drug resistance. It indicates when all antibiotics are ineffective, as in the pre-antibiotic era, and this needs a more comprehensive plan.
Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis
Authors: Carpentier Marie-Christine , Receveur Anne-Elodie , Cadoudal Adrien , Merret Rémy
Published: February 2025

Background

mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process. This pathway has emerged as an evolutionarily conversed mechanism essential for specific physiological processes in eukaryotes, especially in plants. In Arabidopsis, this pathway is targeted mainly by the exoribonuclease XRN4. However, the details of the molecular regulation of this pathway are still unclear.

Results

In this study, we first tested the role of the 3ʹ-phosphoadenosine 5ʹ-phosphate (PAP), an inhibitor of exoribonucleases in the regulation of CTRD. Using 5’Pseq approach, we discovered that FRY1 inactivation impaired XRN4-CTRD activity. Based on this finding, we demonstrated that exogenous PAP treatment stabilizes CTRD mRNA targets. Furthermore, we also tested the implication of the exoribonuclease DXO1 in CTRD regulation. We found that DXO1, another exoribonuclease sensitive to PAP, is also involved in the CTRD pathway, probably by targeting NAD+-capped mRNAs. DXO1 specifically targets mRNAs linked to stress response.

Conclusions

Our study provides further insights into the regulation of CTRD in Arabidopsis and demonstrates that other exoribonucleases can be implicated in this pathway.
Perceived social support and self-stigma as factors of COVID-19 booster vaccination behavior and intention via cognitive coping and emotion regulation among people infected with COVID-19 in Hong Kong
Authors: Zhang Xiaoying , Luan Yiming , Tang Yihan , Lau Mason M. C. , Yu Yanqiu , Gu Jing , Lau Joseph T. F.
Published: February 2025

Background

It is imperative to promote behavior/intention of taking up booster COVID-19 vaccination (BI-BV) among people who have ever contracted COVID-19 (PECC). The aims were to investigate the prevalence of BI-BV and its associations with perceived social support. Guided by the stress coping theory, we tested mediators between perceived social support and BI-BV via self-stigma, active coping, and maladaptive emotion regulation (rumination and catastrophizing).

Methods

A random population-based telephone survey was conducted among adult PECC having completed the primary series of COVID-19 vaccination prior to the diagnosis; 230 participants were interviewed from June to August 2022 during the fifth (last) major outbreak in Hong Kong. The associations between the independent variables and BI-BV were tested by logistic regression analysis. A structural equation model (SEM) tested the indirect effects of the latent variables of self-stigma, active coping, and maladaptive emotion regulation between the latent variable of perceived social support and BI-BV.

Results

The prevalence of BI-BV was 62.2%. It was associated with age, marital status, full-time employment, and chronic disease status. The logistic regression analysis found that BI-BV was positively associated with perceived social support (ORc = 1.31, 95% CI: 1.12– 1.54), active coping (ORc = 1.40, 95% CI: 1.10– 1.79), rumination (ORc = 1.75, 95% CI: 1.13– 2.70), and catastrophizing (ORc = 3.12, 95% CI: 1.49– 6.51) and negatively associated with self-stigma (ORc = 0.80, 95% CI: 0.72– 0.88). In the SEM analysis, the positive association between perceived social support and BI-BV was fully mediated: 1) via self-stigma (β = 0.07, 95% CI: 0.03– 0.14), 2) via active coping (β = 0.06, 95% CI: 0.02– 0.12), and 3) via self-stigma and then active coping (β = 0.01, 95% CI: 0.002– 0.04). Two of these indirect paths involved active coping. The indirect paths involving maladaptive emotion regulation were all non-significant.

Conclusions

Perceived social support was associated with BI-BV, and was mediated via self-stigma, active coping, and serially self-stigma then active coping but not emotion maladaptation. The data supported the stress cognitive coping model in explaining the association between perceived social support and BI-BV. Interventions promoting BI-BV may consider modifying the observed significant factors. Future longitudinal studies are warranted to confirm the findings.