bluuebunny/crossref_metadata_2025 huggingface dataset:
Nghiên cứu cường độ và độ va đập của bê tông phân loại chức năng sử dụng sợi polypropylene và tro bay
Authors: Luân Võ Minh , Trinh Bùi Phương
Published: September 2022

Bài nghiên cứu này khảo sát cường độ chịu nén, cường độ chịu kéo khi uốn và độ va đập của bê tông phân loại chức năng (FGC) có hai lớp bê tông (bao gồm lớp trên và lớp dưới với chiều cao mỗi lớp bằng nhau). Các loại bê tông được nghiên cứu bao gồm bê tông thường, bê tông tro bay với hàm lượng tro bay thay thế xi măng là 20 % theo khối lượng và bê tông cốt sợi với 0,3 % hàm lượng sợi polypropylene (PP) theo thể tích bê tông. Kết quả chỉ ra rằng việc sử dụng tro bay kết hợp với sợi PP đã giúp cải thiện đáng kể cường độ chịu nén, cường độ chịu kéo khi uốn và độ va đập của FGC tại 28 ngày tuổi. Kết luận rằng FGC có thành phần là sự kết hợp giữa bê tông tro bay (lớp trên) với bê tông tro bay chứa sợi PP (lớp dưới) là FGC tối ưu nhất về mặt kết cấu chịu lực và về mặt kinh tế trong bài nghiên cứu này.
Morphological of Zinc Ferrite Nanostructure Using the Hydrothermal Synthesis
Authors: Lestari Kiki Rezki
Published: September 2022

Over the last two decades, many methods for synthesizing various ZnFe2O4 nanostructures of uniform size and shape, such as nanospheres, nanoflowers, nanorods, and nanotubes, have been developed. It seems challenging to investigate a practical and cost-effective method to synthesize cubic ZnFe2O4 magnetite with cubic morphological properties in an aqueous solution. The morphology of zinc ferrite nanostructures is mostly random and non-uniform. The objective of this study is to create reasonably uniform single-crystal zinc ferrite nanocubes. The hydrothermal method was used to successfully sample zinc ferrite by varying the amount of (En) ethylenediamine (0 - 2.4 mL) in the solution. The outcomes demonstrated that the nanocubes, with a particle size of nearly 48 nm, had a more uniform morphology than other samples. The morphology and dimensions of the samples were examined using scanning electron microscopy in conjunction with energy dispersion X-ray spectroscopy.
Rendimiento de futuros maestros en problemas verbales de "parte de"
Authors: Sanz Maria T , López-Iñesta Emilia
Published: September 2022

Este trabajo presenta los resultados preliminares de un experimento piloto en el que futuros docentes de Educación Primaria han de resolver problemas aritméticos de libros de texto de primaria relacionados con el uso de fracciones a través de un entorno tecnológico. El objetivo principal del experimento, además de evaluar los conocimientos del futuro profesorado, es medir el desempeño de los estudiantes en función del tipo de retroalimentación recibida tras responder preguntas de opciones múltiples. Los datos recopilados nos permiten verificar el impacto positivo de usar mensajes con ayudas en comparación al uso de solo mensajes de correcto o de error. Por otro lado, se consolida una metodología para utilizar la medición del tiempo de lectura del alumnado proporcionada por el entorno tecnológico como proxy para determinar la complejidad de los problemas verbales.
Matemática, Arte y Tecnología a luz de la Teoría de las Situaciones Didácticas
Authors: Pinheiro Figueroa Teodora , Luna Valenzuela Maritza
Published: September 2022

En este trabajo se investigó la posibilidad de articulación entre Matemática, Arte y Tecnología en la enseñanza y aprendizajede gráficos de la función trigonométrica seno. La metodología de enseñanza propuesta es fundamentada en la Teoría de las Situaciones Didácticas. Se realizó esta investigación durante un curso de extensión, cuyo público objetivo eran alumnos del primer añodel curso de licenciatura en matemática de la UTFPR. Las Situaciones Didácticas (SD) fueron desarrolladas de la siguiente forma: discusión sobre el concepto de arte; actividad de creación de diseños, obra de arte, apenas con la forma de la función seno; actividades sobre f(x)=C+A sen(Bx), variaciones de los valores de A, B y C, y realización de gráficos con GeoGebra; relectura de las obras de arte sobre el punto de vista de la función seno. Concluimos que es posible articular Matemática, Arte y Tecnología a partir de SD en un cierto milieu, contribuyendo en el proceso de enseñanza y aprendizaje de los alumnos.
Propuesta didáctica basada en modelización matemática para el aula multigrado. El caso de la topografía
Authors: Rodríguez Mejía Miguel Ángel , Romo Vázquez Avenilde
Published: September 2022

Se presenta una investigación enfocada en el diseño e implementación de un dispositivo didácticoconocido como Recorrido de Estudio e Investigación (REI), fundamentado en el paradigma del cuestionamiento del mundo y en la Teoría Antropológica de lo Didáctico, para un aula multigrado rural de una secundaria colombiana. El objetivo del REI es indagar una cuestión principal, ¿cómo levantar un terreno para la siembra? Lo que posibilita generar relaciones entre las matemáticas escolares y la topografía. En particular, se considera el levantamiento topográfico de terrenos para el cultivo, actividad que es de interés para la comunidad en la que se sitúa la escuela. La metodología de investigación se inspira en la Ingeniería Didáctica (Artigue, 2020), adecuando el análisis preliminar al estudio del levantamiento topográfico y elucidando un modelo praxeológico de referencia, fundamental en la determinación de la cuestión generatriz y en el diseño del REI. El análisis preliminar de la topografía permite generar un diseño didáctico en el que se relacionan justificaciones matemáticas y topográficas para llevar al aula con una actividad no escolar como lo es el levantamiento topográfico con cinta.
La creación de problemas, una buena oportunidad para desarrollar la competencia matemática
Authors: Merino Percy , Torres Carlos , Isidro Lilian , Díaz Wilson , Benavides Humberto
Published: September 2022

De los resultados obtenidos en la Evaluación Censal de Estudiantes (ECE), se ha logrado obtener una aproximación de los logros y dificultades que tienen los estudiantes para formular o crear problemas matemáticos. Desde este escenario, el taller busca evidenciar cómo la creación de problemas permite desarrollar la intuición y creatividad de los estudiantes, sus habilidades para establecer relaciones, interpretar condiciones, argumentar sus posturas y, además, usar de manera flexible sus conocimientos matemáticos. El taller está dirigido a docentes de primaria y secundaria, tendrá un carácter activo, participativo y práctico. En grupos, los participantes identificarán la estructura que debe tener todo problema, las diversas situaciones que pueden ser utilizadas en el aula para formular un problema, atendiendo a los procesos cognitivos que se ponen en juego al crear y resolver problemas, a partir de las evidencias que se tienen en las evaluaciones estandarizadas.
Analisis Pengaruh Leverage, Likuiditas, Dan Ukuran Perusahaan Terhadap Perusahaan Papan Utama Subsektor Tobacco Periode 2013-2020
Authors: Arham Giantry Silatur Rizki  , Muhammad Hafizh Ridha
Published: September 2022

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana kinerja keuangan dari perusahaan papan utama dalam subsektor tobacco di Bursa Efek Indonesia periode 2013-2020 ditinjau dari leverage, likuiditas, ukuran perusahaan, dan profitabilitas. Serta mencari tahu bagaimana pengaruh leverage, likuiditas, dan ukuran perusahaan terhadap profitabilitas perusahaan amatan. Terdapat 32 sampel yang diambil dari laporan keuangan empat perusahaan selama 8 periode dari 2013-2020. Untuk mencari pengaruh variabel independen terhadap variabel dependen digunakan analisis regresi linear berganda menggunakan bantuan software SPSS v.25. Hasil dari analisis menunjukkan bahwa leverage dan likuiditas secara parsial tidak berpengaruh signifikan terhadap profitabilitas, sementara ukuran perusahaan berpengaruh signifikan terhadap profitabilitas.
Penerapan PSAK 46 Pada PT Indofood CBP Sukses Makmur Tbk (ICBP) Sebelum Dan Semasa Pandemi Covid-19
Authors: Hutapea Abraham Sergius Manahan Polorensius , Khosafiah Ristanti Khusnul , Jusikusuma Teta Dirgantara , Wijaya Suparna
Published: September 2022

Tinjauan ini berfokus pada penerapan PSAK 46 pada PT Indofood CBP Sukses Makmur Tbk (ICBP) sebelum dan semasa pandemi Covid-19. Tinjauan ini bertujuan untuk mengetahui sistem penerapan PSAK 46 pada PT Indofood CBP Sukses Makmur, faktor-faktor yang mempengaruhi penerapan PSAK 46 dalam laporan keuangan perusahaan, dan kaitannya dengan peraturan perpajakan. Metode pengumpulan data yang digunakan adalah metode kualitatif dengan melakukan penelitian kepustkaan. Penelitian kepustakaan dilakukan untuk mengumpulkan informasi dari buku, jurnal ilmiah, literature, manuskrip, penelitian sebelumnya, dan sumber lainnya. Berdasarkan sumbernya, data yang digunakan merupakan data sekunder dari laporan keuangan perusahaan tahun 2019 dan 2021. Hasil tinjauan menunjukkan bahwa dalam penerapannya PT Indofod CBP Sukses Makmur Tbk (ICBP) telah mengungkapkan laporan keuangan sesuai dengan PSAK 46. Dampak masa depan pajak telah diungkapkan dalam aset pajak tangguhan dan liabilitas pajak tangguhan perusahaan. Pada masa pandemi Covid-19 perusahaan mengalami peningkatan beban pajak kini yang dapat berkaitan dengan peningkatan penjualan perusahaan. Faktor-faktor yang mempengaruhi penerapan PSAK 46 perusahaan adalah beda tetap perusahaan (meliputi beban kesejahteraan karyawan, representasi, dan sumbangan) dan beda temporer perusahaan (meliputi beban penyusutan dan penyisihan liabilitas imbalan kerja karyawan). Dalam kaitannya dengan perpajakan, salah satu aspek yang mempengaruhi beda tetap dan beda waktu adalah pembebanan biaya perusahaan. Secara fiskal, pembebanan biaya perusahaan diatur dalam Pasal 6 dan 9 Undang-Undang Pajak Penghasilan.
Kinerja Keuangan PT Kalbe Farma Tbk Di Masa Pandemi Covid-19 Tahun 2021
Authors: Royan Ahmad , Utami Gabriela , Dwitama Amarsa , Wijaya Suparna
Published: September 2022

Pandemi Covid-19 ini memberikan dampak negatif yang masif dan telak terutama di sektor kesehatan, namun selain sektor kesehatan terdapat sektor lain yang mendapat pukulan yang cukup berat yaitu sektor perekonomian. Namun walaupun merasakan dampak yang cukup signifikan perusahaan yang bergerak di bidang kesehatan seharusnya memiliki peluang untuk meningkatkan pendapatan di masa seperti saat ini. Untuk mengetahui apakah perusahaan-perusahaan di bidang kesehatan memanfaatkan peluang ini dengan baik kita dapat menganalisisnya dengan melakukan analisis laporan keuangan dengan menggunakan berbagai rasio. Dari hasil analisis laporan keuangan tersebut kinerja keuangan PT Kalbe Farma Tbk di tahun 2021 mengalami peningkatan namun tidak signifikan.
Analisis Perubahan Laba Komersial Perusahaan Sektor Consumer Goods Sebelum Dan Saat Pandemi Covid-19
Authors: Haqie Muh. Fahreza , Wahyudi Nico , Manullang Rafika Surya , Irawan Ferry
Published: September 2022

The Covid-19 pandemic has caused significant impact on the global economy, including Indonesia. Consumer goods companies are also affected by the decline in people's purchasing power due to the lockdown policy. This study aims to analyze changes in the commercial profits of consumer goods companies before and during the Covid-19 pandemic. Observations were made on the financial statements of three consumer goods companies, PT Indofood CBP Sukses Makmur Tbk (ICBP), PT Garudafood Putra Putri Jaya Tbk (GOOD), and PT Siantar Top Tbk (STTP) in the period of 2019 s.d. 2021. This study found that ICBP and GOOD experienced a decrease in ROA, ROE, NPM during the Covid-19 pandemic. An interesting thing was found in STTP where ROA, ROE, and NPM actually increased. The implications of this research can be used for investors in making decisions related to stock investment.
Pandemi Covid-19 telah menimbulkan dampak yang signifikan pada perekonomian global, termasuk Indonesia. Perusahaan consumer goods pun tak luput dari imbas penurunan daya beli masyarakat akibat terbatasnya aktivitas sehari-hari masyarakat. Penelitian ini bertujuan untuk menganalisis perubahan laba komersial perusahaan consumer goods sebelum dan saat pandemi Covid-19. Observasi dilakukan terhadap laporan keuangan tiga perusahaan consumer goods, yaitu PT Indofood CBP Sukses Makmur Tbk (ICBP), PT Garudafood Putra Putri Jaya Tbk (GOOD), dan PT Siantar Top Tbk (STTP) dalam periode 2019 s.d. 2021. Studi ini menemukan bahwa ICBP dan GOOD mengalami penurunan ROA, ROE, NPM pada masa pandemi Covid-19. Hal yang menarik ditemukan pada STTP di mana ROA, ROE, dan NPM justru mengalami peningkatan. Implikasi dari penelitian ini dapat digunakan bagi para investor dalam pengambilan keputusan terkait penanaman saham.
CONTRASTIVE ANALYSIS BETWEEN INDONESIAN AND ENGLISH IN ADJECTIVE FOR OPINIONS
Authors: Situngkir Artha Yuni Trimedia , Situmeang Khaterina Vonbora , Hutauruk Rut Maria
Published: September 2022

This study concerns the differences between the two languages, with Indonesian as the source language and English as the target language. And the problem limitation is focused on analyzing the differences in adjectives for feelings between English and Indonesian in Beauty and the Beast's video, https://youtu.be/IMrMILXMUaQ especially those that concentrate on the lexis (the total number of words in the language). This research used descriptive qualitative research. The technique of analyzing data used in this study is based on contrastive analysis from lexis in an adjective for feeling. Researchers searched and found data from YouTube. After that, the researcher analyzes each word from the story of Beauty and the Beast, which is included in the adjective for opinion. And then, the researcher looks for words that have the same meaning or are included in the adjective for opinion by using an English dictionary, then compares with the same word in Indonesian using the Indonesian dictionary. The results of the analysis show that there are 4 types of adjectives found in the video based on the rules, namely: adjective for opinion, adjective for general size, adjective for age, and adjective for material. To compare the number of words in Indonesian and English, the researcher focused on comparing the types of adjectives for opinion in the video. There are 21 words found in the text to compare, and each one has a different number of lexis.
ANALYSIS SUFFIXES ON REPORT TEXT “WASHINGTON D.C”
Authors: Rajagukguk Fretty Riana , Purba Irene Stefani Mutiara , Sitepu Rachel Yolanda , Sitanggang Anita
Published: September 2022

Suffix is one component that can be used to form new words in English. The suffix used in this case is a beginning suffix. The purpose of this study to finding the form, function and meaning of the beginning suffix found in "WASHINGTON DC" in the Report Text. The form, function and meaning of the beginning affixes found are classified According to the theory by Plag (2002) in his book "Word-Formation in English." The results of this study indicate that there are four types of suffix, namely "nominal suffixes," "verb suffixes," "adjectival suffixes" and "adverbial suffixes." In this study the author uses qualitative research, to analyze the suffix in the report text "Washington DC". Qualitative research as the study of the real of phenomena mainly suitable for answer the questions of why the thing is not inspect, and focusing on intervention improvement. It can be said that there are four forms of suffixes found in the data source, namely nominal suffix, verbal suffix, adjectival suffix and adverbial suffix. In Indonesia there are seven types of suffixes, namely: -an, -I, -kan, -kah, -ku, -mu, -nya, -pun. Research findings showed that beginning suffixes was found in the washingthon D.C., they are suffix -al, -s, -ist, -ion, -ing, -ed, -ly, - ous, -ence, in Indonesia we found suffixs -kan, -an, -nya.
PERKEMBANGAN PSIKOLOGI ANAK KARENA DAMPAK BULLYING
Authors: Fadillah Ahmad Arif , Meidanty Cindy Arlinda , Haniifah Fiilzah , Utami Nabela Kanti , Amalia Novia , Endjid Prissis , Hasanah Rihlah , Rahman Rif’an Maulana , Kausar Rizky Ahmad , Setiawan Thoni Putra
Published: September 2022

This research is motivated by the large number of mass media reporting on acts of bullying committed by children and adolescents today. This research was conducted by the education management course. The bullying experienced by the victim is in the form of verbal and physical bullying. The purpose of this study is to find out how the psychosocial impact of bullying victims in everyday life, as well as to provide education to parents of victims to be more sensitive to the developments and problems faced by children, especially to continue to monitor children's interactions. The results of this study can be concluded, namely that bullying cases have a negative impact on victims of bullying, namely first, children who are victims of bullying are anti-social towards the playing environment, victims withdraw from the social environment and to interact socially. Being indifferent to what is happening in the surrounding environment. Second, the impact on the victim's psychology is that there is a deep depression that begins with a sense of trauma experienced and then turns into depression.
THE CULTIVATION OF MEMORY IN THE GÜLEN COMMUNITY
Authors: Hermansen Marcia
Published: September 2022

This paper explores the cultivation of ‘memory’ as reflected in the teachings of Fethullah Gülen and the practices of the community inspired by him. For example, it discusses how particular places, themes, and images are remembered within the movement, evoked and re- enacted so as to create community and inspire a sense of participation and allegiance. Although the history of the Gülen movement is relatively brief-some forty years or less, prac- tices of sharing memories inspires a collective sense of community and even sacrality. In this paper memory within the Gülen movement will be presented in terms of its reso- nance with broader themes in Turkish collective memory such as Anatolian/Turkish Islam, the Ottoman cultural ideal, etc. In addition, the relationship of particular remembered sym- bols and experiences in the history of the Gülen movement to its current practices will be elaborated, for example ‘the Light Houses’ and ‘camps’. All of this will be set against the background of the topography of a movement that has ex- panded its imagination and its practice from local to national and ultimately global contexts.
Fashion Education and Sustainability in The Same
Authors: Kumar Madhurendra
Published: September 2022

History reveals a series of nasty occurrences which affected mankind severely resulting in a reformed shape of the complete eco-system where humans have to start again from scratch to showcase their resilience towards the disorder, the same is true in the case of recent pandemic Covid-19 also. This Chaos affected all the facets of human life whether it is society, industry, ecology, belief system, or the way we live on the planet earth. So, seeing this Fashion Academia has planned to make curriculum accordingly to fight this issue. They are trying to create a battery of designers who can understand what sustainability is all about. To delve deeper into this tale, a series of research papers, journal articles, research projects, media reports, and forecasts by a reputed agency is reviewed and data analysed which will be beneficial in unlocking the true potential and adaptive measures for the future.
Mathematical Creativity, Mathematics Self-Efficacy, and Mathematics Problem-Solving Performance of High School Students in Different Curricular Programs
Authors: Bales Michelle P. , Estomo Rene T.
Published: September 2022

This descriptive-correlational study generally aimed to determine if mathematics self-efficacy and mathematical creativity can predict mathematics problem-solving performance of high school students. Further, it also aimed to determine the level of mathematics self-efficacy, level of mathematical creativity, and level of problem-solving performance of high school students as a whole and when classified according to curricular program. The respondents of this study were the two hundred twenty-four (224) high school students enrolled in a national high school in Iloilo. Cluster sampling was used to determine the participants in the study. Three researcher-made instruments were used in this study: the Mathematics Self-Efficacy Rating Scale (MSERS), the Mathematical Creativity Test (MCT), and the Mathematics Problem-Solving Test (MPST). These instruments were content-and face-validated by a panel of three experts and were pilot tested to determine their administrability. Mean and standard deviation were employed for the descriptive analysis of the study. The inferential statistical tools employed were the Oneway Analysis of Variance (ANOVA), Pearson’s Product-moment Correlation Coefficient (Pearson’s r) and the Stepwise Multiple Linear Regression Analysis, all set at .05 alpha level of significance. This study found that the participants’ level of mathematics self-efficacy and mathematics problem-solving performance when taken as an entire group was average, while their level of mathematical creativity, as a whole and in terms of fluency, flexibility, and originality, was moderately low. It was also found out that there existed a significant difference in self-efficacy; creativity in terms of fluency, flexibility, and originality; and mathematics problem- solving performance when the participants were classified according to curricular program. In addition, it was found that a moderate positive correlation existed between the participants’ mathematics self-efficacy and their mathematical creativity. Finally, the result of this study revealed that mathematics self-efficacy and mathematical creativity are predictors of mathematics problem-solving performance when participants were taken as a whole group. When classified according to curricular program, mathematics self-efficacy and mathematical creativity are predictors in the Regular Class participants but not in the Special Science Class, School for the Arts, and School of the Future participants. Furthermore, mathematical creativity was found to be the best predictor of mathematics problem solving performance when participants were taken as a whole group and when classified as to curricular program
Forecasting Hydropower Generation in Ghana Using ARIMA Models
Authors: Sarpong Smart Asomaning , Agyei Akwasi
Published: September 2022

In this study, an Autoregressive Integrated Moving Average (ARIMA) model was used to forecast Ghana’s Akosombo dam level and hydropower generation by the end of year 2022. Data used for this study span from January 2010 to December 2019. Base on the final ARIMA model, power generation is forecasted to decrease from 398 Megawatts/hr in December 2019 to approximately 374 Megawatts/hr by December 2022. On the other hand, water level of the Akosombo dam is predicted to decrease marginally from 264.8 ft in December 2019 to approximately 255.19 ft by December 2022. The Volta River Authority (VRA) and managers of the electricity production in Ghana are encouraged to be proactive in expanding energy production by turning more to renewable energy sources. In the coming years, as they seek to provide sustainable electricity for their cherished customers, investment decisions should be directed towards protecting the volta river from drying up due to human and climatic activities as well as expanding energy mix.
On the Interest Rate Sensitivity of Aggregate Investment in the Euro Zone
Authors: Reichel Richard
Published: September 2022

The purpose of this paper is to estimate the response of aggregate investment to interest rate changes in the Euro zone. Keynesian macroeconomic theory assumes that there is an inverse relationship between investment and interest rates, but empirical evidence is inconclusive. Interestingly, there are no studies relating macroeconomic investment to central bank rates in the Euro zone, despite the importance of this question for European monetary policy. To check whether the inverse interest rate – investment nexus holds for the Euro zone we conducted a comprehensive econometric study. In particular, we estimated a modified accelerator model that related aggregate investment in levels and the investment-to GDP (gross domestic product) ratio to income, interest rates and a set of control variables. The model was estimated by OLS (ordinary least squares) and simultaneous-equations methods such as TSLS (two-stage least squares) and GMM (generalized method of moments). The study was unable to uncover a significant interest rate effect on investment in the Euro zone. Thus, there is little support for the expansionary monetary policy of the European Central Bank.
Önellátásukban korlátozott betegek szájápolásának jelentősége
Authors: Ványi Zsuzsa
Published: September 2022

Fogászati prevenció alatt – különösen a jelen cikk keretein belül – nem csak és kizárólag a szájüregi prevenciót kell érteni. A cikk elsődleges célja, hogy az egészségügyi szakdolgozók számára nyújtson egy közérthető és átfogó képet a megfelelő szájhigiénia és a fekvőbetegek napi szájápolásának jelentőségéről. Ma már látjuk, hogy a fogászat sokkal több, mint a szájüregi elváltozások szakszerű kezelését, illetve az ilyen elváltozások megelőzését művelő tudományág. Tudományosan igazolt tény, hogy a szájhigiénia, illetve annak minősége, állapota az általános egészségre is alapvető kihatással van, nagymértékben befolyásolja egyéb, sokszor igen súlyos betegségek kialakulását, lefolyását, kezelését és a gyógyulás menetét. Jelen pillanatban is a szakma részéről több kutatás folyik a szájüreg állapota és egyéb szisztémás betegségek kialakulásának összefüggéseire, kimutatására vonatkozóan.
De la historia de la medicina a la medicina de precisión
Authors: Anaya Cabrera Juan Manuel
Published: September 2022

Fragmento.

El ser humano busca irremediablemente un sentido a su vida. Esa búsqueda se acentúa con la edad o durante la enfermedad. Todo ser humano, en la lógica de la vida, enfermará. Unos antes que otros. Cada cual, entonces, hará lo mejor de sí hasta cuando descubra que lo pudo haber hecho mejor. O lo contrario. Este número de MEDICINA ofrece un espacio para estas reflexiones.

Los artículos sobre la historia de la medicina tratan aspectos que merecen ser recordados como testimonio del inicio de las capacidades científicas del país. No en vano la modernidad es el resultado de la crítica constructiva del pasado. La medicina de precisión, un ejemplo evidente de esta modernidad, ha dejado de ser un concepto de investigación y se ha convertido en la mejor opción de atención médica, que aprovecha toda la información de un individuo para predecir el tránsito de la salud a la enfermedad (prevención primaria) o para conocer el riesgo de desenlaces en un paciente (prevención secundaria y terciaria), incluyendo la respuesta a los tratamientos.
Características asociadas a requerimiento de hospitalización y manejo en unidad cuidado intensivo en pacientes con enfermedades reumáticas e infección por SARS-CoV-2
Authors: Fernández-Ávila Daniel G. , Muñoz-Velandia Óscar , Ursida-Serrano Valentina
Published: September 2022

Objetivo: Describir los desenlaces de los pacientes con enfermedades reumáticas e infección por SARS-CoV-2, que ingresaron por el servicio de urgencias de un hospital universitario, y determinar qué características se asociaron a requerir hospitalización por más de un día, o manejo en Unidad de Cuidados Intensivos (UCI). Materiales y métodos: Cohorte retrospectiva de pacientes con enfermedades reumáticas e infección por SARS-CoV-2, atendidos en el Hospital Universitario San Ignacio en Bogotá, Colombia, entre marzo y diciembre de 2021. Se comparan los grupos de pacientes hospitalizados en sala general y en UCI vs aquellos que no requirieron hospitalización. Resultados: De los 49 pacientes (69,5 % mujeres, edad 55.7 ± 17,3 años), 39 (79,6 %) fueron hospitalizados, y 13 (26,5 %) manejados en la UCI. Las enfermedades reumáticas más comunes fueron lupus eritematoso sistémico (36,7 %) y artritis reumatoide (26,6 %). La mortalidad global fue 20,4 %. Entre quienes requirieron manejo en UCI 61,9 % fueron hombres, 61,5 % obesos, 69,2 % requirieron ventilación mecánica y 53,8 % fallecieron. La mediana de estancia en UCI fue 9 días (RIQ 5-14). El uso de glucocorticoides y la presencia de comorbilidades fue similar entre los diferentes grupos. Conclusión: La mayoría de pacientes con enfermedades reumáticas e infección por SARS-CoV-2 requirieron hospitalización y un cuarto de ellos manejo en UCI. La mortalidad en el grupo de pacientes que requirió hospitalización fue mayor a la reportada en la literatura para pacientes sin enfermedades inmunomediadas, lo cual sugiere que las enfermedades reumáticas están relacionadas con un mayor riesgo de mortalidad.
Perspectiva oncológica de la medicina de precisión y su implementación en pacientes pediátricos y adultos con genes de fusión NTRK: una visión para Colombia
Authors: Vargas Carlos , Sotelo Carolina , Chamorro Diego F. , Pino Luis Eduardo , Archila Pilar , Sua Luz Fernanda , Sarmiento Isabel , Rodríguez July , Ruíz Patiño Alejandro , Rojas Leonardo , Carranza Hernán , Otero Jorge , Ricaurte Luisa , García-Robledo Juan Esteban , Ordóñez-Reyes Camila , Corrales Luis , Martín Claudio , Raez Luis , Rolfo Christian , Arrieta Oscar , Zatarain-Barrón Lucía , Mosquera-Paternina Andrés Felipe , Forero Martínez Yency Johana , Cardona Andrés F.
Published: September 2022

La oncología de precisión, definida como la perfilación molecular de los tumores para identificar alteraciones modulables, se ha desarrollado rápidamente para integrarse en la práctica clínica. Las pruebas genómicas involucran diversas partes interesadas que trabajan coordinada y articuladamente para controlar la logística de las muestras de tejido tumoral y desarrollar las pruebas en laboratorios con altos parámetros de calidad, donde el análisis apropiado conduce a resultados reproducibles. Los médicos deben estar familiarizados con las variantes genómicas informadas y con la tecnología utilizada para determinarlas, incluidas las limitaciones de los informes y las metodologías actuales. La interpretación de los hallazgos genómicos se realiza de manera óptima gracias al aporte multidisciplinario, necesario para reducir la incertidumbre de las recomendaciones relacionadas con las variantes documentadas. Los genes 1/2/3 del receptor neurotrópico de la quinasa para la tropomiosina (NTRK) codifican las quinasas del receptor de tropomiosina (TRK) A/B/C, respectivamente. Los reordenamientos cromosómicos que causan fusiones del gen NTRK pueden dar como resultado la activación constitutiva de las proteínas TRK, que actúan como impulsores oncogénicos a través de la activación de diversas vías de crecimiento celular. Las fusiones del gen NTRK ocurren en ~0,3 % de los tumores sólidos, aunque su incidencia varía según el tipo de cáncer. Su prevalencia es >90 % en algunas neoplasias raras como el carcinoma secretor de mama y el carcinoma secretor análogo de la glándula salivar (MASC). Los inhibidores de TRK (larotrectinib, entrectinib y repotrectinib) son activos en los tumores positivos para la fusión de NTRK, y han permitido cambiar el curso natural de múltiples enfermedades. El artítuculo desarrolla una revisión integral sobre la perspectiva de la medicina de precisión y su implementación en pacientes pediátricos y adultos con genes de fusión NTRK en Colombia.
Dermatitis por contacto con pelos de cyclosternum familiare
Authors: Traviezo Valles Luis Eduardo , Rothe Julia
Published: September 2022

Introducción: Cyclosternum familiare (Simon, 1889) es una araña endémica en la población El Manzano (Venezuela), que como defensa libera pelos que producen dermatitis por contacto. Materiales y Métodos: Estudio descriptivo del caso, con análisis retrospectivo e identificación taxonómica del artrópodo incriminado. Presentación del caso: Paciente masculino de 54 años que en dos oportunidades tuvo roce (contacto) con una pantaloneta contaminada con pelos de C. familiare, desarrollando una dermatitis de 33 días de evolución. Discusión: La morbilidad y mortalidad por arañas en Venezuela no superan el 1% del total de reportes por emponzoñamientos por vertebrados o invertebrados y la identificación de las especies involucradas es muy rara. Es la primera vez que se describe el contacto con esta especie como el origen de dermatitis en un paciente de Venezuela. Conclusión: Las setas liberadas por este taxón tienen la capacidad de anclarse a las fibras de algodón de la ropa, resistiendo el lavado con agua y jabón y manteniendo su capacidad irritante por más de un mes.
La criptología de enfermedad
Authors: Barrera Luis Alejandro
Published: September 2022

Intervención del Académico Jaime Bernal Villegas, MD, PhD. en la sesión académica del 18 de noviembre de 2021

He leído con extraordinario interés el libro La Criptología de la enfermedad. Cómo aprendimos a descifrar y corregir enfermedades heredadas, cuyo autor es el doctor y académico Luis Alejandro Barrera, y que es la razón para estar congregados aquí, en la Academia Nacional de Medicina esta noche. Los errores congénitos del metabolismo son un grupo enorme, tal vez mas de 500 entidades, producto de disrupciones en alguna de las vías metabólicas de los seres humanos y de otra cantidad de animales que comparten con nosotros patrones metabólicos comunes. Por la misma razón de ser tantas y tan diversas, no son, en su mayoría, comunes. Voy a citar unas pocas cifras de mi propia experiencia en la Red Colombiana de Medicina Genética -PREGEN- la entidad que creé hace más de 30 años y que se ha encargado de ofrecer el tamizaje neonatal en Colombia y educar a los padres y al cuerpo médico sobre su importancia.
Académico correspondiente Carlos Francisco Corredor Pereira
Authors: González John Mario
Published: September 2022

Fragmento.

Lo que siempre caracterizó a Carlos Corredor Pereira fue su tenacidad, su empeño en promover la excelencia académica, su entusiasmo desbordante, jovialidad y buen humor. Y por supuesto, fiel a su estilo, luchó hasta el final. Si hablamos de un profesor y académico que haya impulsado la investigación y procesos educativos universitarios en biología y biomédica por más de medio siglo, llegamos rápidamente al perfil del doctor Corredor. Nació en Bogotá donde realizó su educación primaria y secundaria, para luego viajar a Estados Unidos donde cursó el pregrado en bioquímica en el Tennessee Wesleyan College, graduándose en 1958. Continuó su formación con una maestría en bioquímica en la Universidad de Missouri en 1961 y el doctorado en la Universidad de Duke en 1968. Su interés científico y tema de trabajo desde sus inicios fueron las enzimas, el metabolismo y la bioquímica nutricional, enfoque con el cual continuó en Colombia como docente de la Universidad del Valle en Cali, entre 1962 y 1992. Allí se desempeñó en diferentes cargos desde la dirección del departamento de Bioquímica hasta la Vicerrectoría de Investigación. En 1993 el Doctor Corredor se trasladó a Bogotá, incorporándose a la Facultad de Ciencias de la Pontificia Universidad Javeriana, allí laboró hasta 2009, ocupando los cargos de director de posgrados y decano académico. En estas universidades colombianas impulsó la creación de programas de maestría, y posteriormente programas de doctorado en diferentes áreas de las ciencias biológicas.
O IMPACTO DA GRADUAÇÃO NA QUALIDADE DE VIDA DO ESTUDANTE DE MEDICINA
Authors: Campos Luyze de Sá , Da Silva Isabella Correa , De Araújo Tatiana D’Ávila Manhães Ferreira , Molin Gabriela Ferreira Dal , Mansur Odila Maria Ferreira de Carvalho
Published: September 2022

Introdução: O conceito de qualidade de vida é amplo e requer uma contextualização no tempo e no espaço, estando relacionado com parâmetros objetivos e subjetivos. Objetivos: Este estudo visa avaliar as modificações na qualidade de vida do estudante de Medicina ao ingressar e ao concluir o curso. Metodologia: A pesquisa é transversal de natureza quantitativa e descritiva. Seu objetivo foi avaliar a qualidade de vida do estudante ao adentrar e ao concluir a graduação. Resultados: Foram avaliados 53 estudantes do 1º e 29 do 12° período. Foi possível observar redução da prática de atividades extracurriculares e um aumento do consumo de drogas e medicamentos entre os alunos do primeiro e último ano. Conclusão: Para que a formação acadêmica seja prazerosa é imprescindível a manutenção dos valores empáticos e da estabilidade emocional, por meio do estímulo de atividades extracurriculares e alerta quanto ao consumo de substâncias prejudiciais à saúde.
Alleviation of cold stress induced oxidative stress in White Leghorn Chicken by Chromium and Vitamin C supplementation
Authors: Mayengbam Prava , Ali M Ayub , Lallianchhunga M C , Tolenkhomba Thingujam Chaa , Goswami Ranjan , KHUKHODZIINAI J S , RANJANA
Published: September 2022

White Leghorn layer chicken experienced cold stress during December, 2019 to January, 2020 with lowestminimum AT and lowest average temperature during later part of January, 2020. Cold stress caused increasein HSP70 and SOD of White Leghorn layer chicken. Supplementation of chromium picolinate (@ 400 μg/kgfeed) and vitamin C (@ 250 mg/kg of feed) alleviated cold stress and cold induced oxidative stress in White Leghornchicken. Alleviation of stress by supplementation of chromium picolinate and vitamin C could be estimated bythe measure of drop in HSP70 and SOD. Supplementation of chromium picolinate and vitamin C also had beneficialimpacts on egg length during cold stress. Combination of chromium picolinate and vitamin C was best to alleviatecold stress while vitamin C was best to lower oxidative stress in layer.
IMPLEMENTING CONTINUAL LEARNING SCENARIOS: REVIEW OF A ML TECHNQIUE
Authors: ARSLAN AYSE
Published: September 2022

One of the biggest traps "AI" (artificial intelligence) projects fall into is demanding an entire solution fit into the ML (machine learning) paradigm. One of the continual learning techniques in ML to overcome this challenge is the so called 'Learning to Prompt for Continual Learning (L2P)' that can be applied to practical continual learning scenarios without known task identity or boundaries. L2P uses a single frozen backbone model and learns a prompt pool to conditionally instruct the model. After discussing main categories of recent continual learning algorithms, this paper provides an overview of LSP by discussing its layers.
EFFECTIVENESS TEST OF THE MULTIPLICATION TECHNIQUE OF PINEAPPLE DISCHARGES (ANANAS COMOSUS) ON THREE GROWING SUBSTRATES
Authors: Larounga TCHANILEY , Ivètte OUAGBENI Amina , Essognim TAGBA
Published: September 2022

The trial focused on the multiplication of pineapple suckers obtained from their cut stems and grown in trays under 3 treatments with 4 repetitions. The objective of the trial is to test the efficiency of the multiplication of pineapple shoots on the three culture substrates. The experimental device is completely randomized. The T1 treatment consists of cow dung, decomposed plant debris, landfill sand, coarse coconut fibers and those partially powdered. The T2 treatment consists of coarse coconut fibers and those partially powdered. The T3 treatment consists only of white sawdust. The results obtained showed that, 30 days before weaning, the high number of rejections (7.62Â±2.25) was obtained from the T1 treatment. The pineapple stems of treatments T2 and T3 gave respectively 5.56Â±2.06 and 6.69Â±3.38 rejections. At the 4th weaning, the rods of the T1 treatment gave more rejections (10.50 Â± 1.29) than those of the T2 and T3 treatments which gave only 8.25 Â± 0.96 and 9.50 Â± 1 respectively 29 rejections. The suckers of the T1 treatment produced more leaves (22.75Â±0.96) on the 60th day after the 4th weaning than those of the T2 and T3 treatments which produced only 20.25Â±0.5 and 22Â± respectively. 0.82 sheets. They also weighed more (69.57Â±0.99g) than those of the T2 and T3 treatments which each gave 49.57Â±1.87g. Thus the approach of the T1 substrate improved the number of suckers, that of the leaves as well as the mass of the suckers.
Implementation of Drug Logistics Management in Pharmaceutical Installations in Sigi Regency Health Office
Authors: Wandira Bertin Ayu , Chikita Marsanda
Published: September 2022

Drug logistics management at the health office is one of the important aspects of the Public Health Center. The purpose of the study was to determine the planning, budgeting of procurement, storage, distribution, and elimination in drug logistics management at the Pharmacy Installation of the Sigi Regency Health Office. This type of research was qualitative with a case study approach. The informants in this study consisted of key informants (the Head of the Pharmacy Installation of the Sigi Regency Health Office), the usual informants (the Pharmacy Installation Staff of the Sigi Regency Health Office), and ordinary informants (the person in charge of managing the pharmacy installation at the Public Health Center). Data collection through triangulation techniques, including in-depth interviews, observation, and documentation using interview guidelines. The results showed that the implementation of drug logistics management at the Pharmacy Installation of the Sigi Regency Health Office in terms of planning, budgeting, procurement, storage, distribution, and elimination, was appropriate as it should be but still had some obstacles. So it is still necessary to improve the implementation of logistics management that is more effective and efficient. It is recommended that the coordination of the Sigi Regency Health Office and the Public Health Center is more optimal in the implementation of drug management.
Potential of Curcumin in Turmeric as a Preventive Modality from Covid-19 in Pregnant Women
Authors: Issalillah Fayola
Published: September 2022

Coronavirus disease 2019 (Covid-19) is a state of health emergency and global concern. Unfortunately, there is no effective therapeutic strategy available in dealing with Covid-19 infection. This can endanger risk groups, especially pregnant women. Various studies are competing to develop the therapeutic potential of Covid-19 from herbal compounds, one of which is curcumin. This study aims to determine the potential of curcumin in turmeric as a preventive modality from Covid-19 in pregnant women. This paper uses literature study. Based on the results obtained, the anti-viral, anti-inflammatory, anti-oxidant and anti-coagulant effects in curcumin play an important role in preventing the development of the SARS-CoV-2 virus in humans based on various mechanisms. Low doses of curcumin have also been proven safe for consumption by pregnant women. Therefore, routine and low-dose curcumin supplementation can prevent Covid-19 infection in pregnant women.
Human Resources based on Total Quality Management
Authors: Arifin Samsul , Darmawan Didit , Hartanto Cahya Fajar Budi , Rahman Abdul
Published: September 2022

Human resources owned by a company is the strength it has in order to be able to compete with other companies. company management will always create strategies to be able to create quality human resources. The strategy carried out will continue to move dynamically along with technological advances. One way to improve the quality of human resources is by implementing Total Quality Management or TQM. The application of TQM will provide many benefits for the company and the employees themselves. With TQM all aspects of the company such as leadership and employee training will be well planned and supervised. This study aims to determine the role of TQM in empowering human resources in companies. All expert opinions say that the implementation of TQM will have a positive impact on empowering the human resources they have. The disadvantage of implementing TQM is that the costs incurred are quite high. Management needs to think of more strategies in order to get a lot of benefits but not interfere with the company's financial situation.
Cotton Improvement Conference 1948-2018 and Cotton Genetics Research Award 1961-2018
Authors: McCarty Jr. Jack C.
Published: September 2022

The 70th anniversary of the Cotton Improvement Conference (CIC) was celebrated at the 2018 annual meeting. The CIC was organized in 1948 at a meeting held in conjunction with the Southern Agricultural Workers in New Orleans, LA. The structure of the CIC was informal with the purpose of allowing state, federal, and other cotton workers to report on research, exchange ideas and facilitate research program planning. The first meeting was held in Baton Rouge, LA in 1949. Few records remain of the early years of the conference even though mimeograph proceedings were produced. In 1956, the CIC joined the Beltwide Cotton Production Conference and has continued to meet annually with this group. In 1956, the Beltwide Conferences consisted of the Cotton Disease Council, founded in 1936, Cotton Defoliation – Physiology, established in 1942, Cotton Insect Control (1947), and CIC. Through the years members of the CIC have played key roles in the Joint Cotton Breeding Policy Committee, National Cotton Variety Test Program, and the Cotton Winter Nursery. The reporting of research, exchanging of ideas, and cooperation among public and private cotton workers has persisted throughout the 70 years of the CIC and these activities have benefitted the cotton industry. The Cotton Genetics Research Award was established in 1961 by the commercial cotton breeders to recognize scientific achievement in basic research in cotton genetics, cytogenetics and breeding.
Custos da atividade de carcinicultura dos microprodutores do nordeste brasileiro
Authors: Nunes De Paiva Krissia Luana , Backes Steppan Adriana Isabel , Rodrigues Boente Diego , Medeiros Alves de Oliveira Ridalvo , da Rocha Carvalho Daniele
Published: September 2022

O objetivo do estudo é identificar os custos de produção dos microprodutores de camarão da região de Tibau do Sul, no estado do Rio Grande do Norte, bem como, avaliar a viabilidade econômica/operacional da ativi-dade. Os dados coletados foram separados em três grupos, de acordo com o volume de produção anual e os custos foram classificados em diretos e indiretos, fixos e variáveis. Foram calculadas as médias dos custos totais de produção dos carcinicultores por grupo, as médias do custo de camarão por quilo, faturamento, re-sultado operacional e a média da margem de contribuição. Os resultados evidenciam que os maiores custos na produção são com materiais diretos. Os custos variáveis são os mais representativos, com destaque para a mão de obra, ração e povoamento (pós-larvas). No que se refere aos custos fixos, o custo com manutenção se apresentou como mais relevante. Com relação ao custo do camarão, foi possível identificar que ele é influen-ciado pela área dos viveiros e pelo volume de produção, sendo o custo do quilo maior para os produtores com baixa capacidade produtiva. Verificou-se que a atividade é lucrativa e viável, inclusive em períodos em que o preço de venda é baixo.
La mesoeconomía de la ‟dona”, un nuevo enfoque para el desarrollo de los aglomerados productivos
Authors: Dufour Gabriela
Published: September 2022

En 2008, en plena crisis global, proponía un “Tablero de Comando Complejo para un aglomerado productivo en la meso economía”. El tiempo y los acontecimientos marcan la necesidad de nuevos análisis, intercambios y acciones para mejorar la gestión de las organizaciones, y consecuentemente el “Tablero”.
En las unidades productivas, la apropiación de la innovación de las sucesivas revoluciones tecnológicas, así como la sostenibilidad ambiental, (más aún a partir del Covid-19) son elementos de gran impacto en su transformación y supervivencia.
Entre el Tablero Complejo originalmente propuesto y el modelo formulado por Kate Raworth representado con la DONA a escala de ciudades, detectamos puntos de coincidencia, que facilitaron la reformulación de la herramienta original como guía de imprescindible adaptabilidad.
Inicialmente, el foco se limitaba a una escala socio productiva y ecológica local al que le incorporamos una mirada global y nuevas dimensiones (lentes), que si bien complejiza el análisis, también colaboran en atender los desafíos que impone el siglo XXI a quien realiza actividades productivas y quiere alcanzar los máximos niveles de competitividad desde una perspectiva social y ambientalmente sostenible.