bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Occupational Therapy After Hip Fracture Surgery Effective in Improving Function?
Authors: Lee Sang Yoon , Jung Se Hee , Lee Shi-Uk , Ha Yong-Chan , Lim Jae-Young
Published: October 2018

Objective

The aim of the study was to evaluate whether occupational therapy (OT) improves activities of daily living and overall physical functioning of patients after hip fracture surgery.

Data Sources

The data sources are PubMed-Medline, Embase, and Cochrane Library databases.

Review Methods

We searched for randomized controlled trials comparing occupational therapy with comprehensive postoperative care (without occupational therapy) after hip fracture surgery. A pairwise meta-analysis using fixed- and random-effects models was performed. The primary outcome of interest was performance of activities of daily living assessed in any manner. The secondary outcomes were other functional parameters: (1) physical function; (2) health perception and emotion; and (3) fall occurrence. Effect sizes were computed as standardized mean differences with 95% confidence intervals.

Results

Five randomized controlled trials including a total of 524 participants were retrieved. There was a trend toward improvement in activities of daily living, physical function, and fall occurrence, and these changes were not significant. However, health perception and patient emotions improved significantly in the occupational therapy group (standardized mean difference = 0.391, 95% confidence interval = 0.104 to 0.678, P = 0.008).

Conclusions

Occupational therapy after hip fracture surgery seems to improve overall function. Indeed, the positive effects of occupational therapy on health perception and emotions were evident. Therefore, occupational therapy can be suggested in comprehensive rehabilitation programs after hip fracture surgery.
FDG PET/CT in a Case of Dural Amyloidoma
Authors: Ran Pengcheng , Liu Yupin , Liang Xiang , Zhang Yu , Dong Aisheng
Published: October 2018

Dural amyloidoma is an unusual presentation of central nervous system amyloidosis. A 49-year-old woman presented with 1-month history of repeated episodes of vertigo. Precontrast MRI showed dural thickening over right frontal convexity with signal intensity similar to white matter. Postcontrast T1-weighted images showed remarkable enhancement of the lesion. Dural amyloidoma was confirmed by partial resection of the lesion. The patient underwent no further treatment. A follow-up FDG PET/CT showed increased FDG uptake of the residual dural amyloidoma. This case indicates dural amyloidoma should be included in the differential diagnosis of abnormal FDG uptake in dural lesions.
Diagnosing Polyps on Transvaginal Sonography
Authors: Fadl Shaimaa A. , Sabry Ahmed Saied , Hippe Daniel Scott , Al-Obaidli Amal , Yousef Reda Ramadan , Dubinsky Theodore J.
Published: October 2018

Background

Endometrial polyps are localized overgrowth of glands, stroma, and blood vessels and reported in 13% to 50% of women with dysfunctional uterine bleeding. Transvaginal ultrasound (TVUS) is the initial noninvasive modality of choice for the evaluation of endometrial polyps. The addition of intrauterine contrast by adding saline during saline infusion sonohysterography (SIS) has been reported to improve diagnostic accuracy in detecting of endometrial polyps. Given all the technical advances in ultrasound instrumentation and technology over the last 10 years, we wanted to revisit the diagnostic accuracy and associated confidence level of TVUS and SIS for detecting endometrial polyps.

Objective

The aims of this study was to determine the diagnostic accuracy of TVUS in detecting endometrial polyps in patients with abnormal uterine bleeding or infertility and to determine if SIS is necessary when the level of confidence that a polyp is present is high.

Materials and Methods

A total of 144 patients who underwent both TVUS and SIS for the evaluation of abnormal uterine bleeding and infertility were retrospectively identified and independently reviewed by 2 blinded readers. Examinations were graded as polyps absent, equivocal for polyps, and polyps definitely present. Interreader agreement for TVUS grade was assessed using Cohen kappa. Hysteroscopy and histopathology were used as the reference standard for the final diagnosis. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value were calculated, and confidence intervals (CIs) were computed.

Results

From the combined assessments of both readers (288 reads), 24.7% were definitively positive for polyps, 47.2% were negative, and 28.1% were equivocal by TVUS. Interreader agreement was good with a kappa of 0.66 (95% CI, 0.56–0.76). Among the 108 reads where hysteroscopy/histopathology results were available, even when diagnostic confidence for the presence of polyps was high, TVUS had a PPV of 65.2% (95% CI, 42.1%–88.9%). This PPV was significantly lower than the corresponding PPV of SIS of 88.5% (95% CI, 77.4–100.0%; P = 0.021 for the difference).

Conclusion

Saline infusion sonohysterography has better diagnostic accuracy for the detection and exclusion of endometrial polyps than TVUS, even in cases where the diagnostic confidence for the presence of polyps is high. Saline infusion sonohysterography may still be needed to confirm a TVUS diagnosis for polyps to limit the number of negative hysteroscopies.
Comparison of Real-Time and Static Ultrasonography Diagnoses for Detecting Incidental Diffuse Thyroid Disease
Authors: Baek Hye Jin , Kim Dong Wook , Lee Yoo Jin , Ahn Hye Shin , Ryu Ji Hwa
Published: October 2018

This study aimed to compare diagnostic accuracy of real-time and static ultrasonography (US) for differentiating diffuse thyroid disease (DTD) from normal thyroid parenchyma (NTP). At 4 participating institutions, 203 patients underwent real-time thyroid US before thyroid surgery. For static US, the same radiologists retrospectively evaluated US findings on a picture archive and communication system after 4 weeks. In real-time and static US diagnoses, US category included no DTD, indeterminate, suspicious for DTD, and DTD. We investigated the diagnostic accuracy of real-time and static US with a receiver operating characteristic curve analysis using histopathologic results as the reference standard. Histopathologic results exhibited NTP (n = 139), Hashimoto thyroiditis (n = 24), non-Hashimoto lymphocytic thyroiditis (n = 33), and diffuse hyperplasia (n = 7). Of 203 patients, there were significant differences in echogenicity, echotexture, glandular margin, and vascularity of the thyroid gland and US category between NTP and DTD groups in both real-time and static US diagnoses (P < 0.001). The diagnostic indices of real-time and static US were highest when the cutoff criterion was chosen as 1 or more abnormal US features. In addition, US category was the only feature with a significant difference between DTD and NTP groups regardless of the practical experience. The receiver operating characteristic curve analysis showed that real-time US was superior to static US in the diagnostic accuracy; however, there was no significant difference (P = 0.09). In conclusion, real-time and static US can be helpful for detecting incidental DTD by using US classification based on abnormal US features.
Simultaneous Bilateral Microtia Reconstruction Using Single-Expanded Postauricular Flap Without Skin Grafting
Authors: Xing Wenshan , Wang Yue , Qian Jin , Wang Bingqing , Zhou Xu , Liu Tun , Zhang YongBiao , Zhang Qingguo
Published: October 2018

Background

Auricular reconstruction in patients with congenital microtia permits craniofacial balance and harmony, especially in patients with bilateral microtia. However, published techniques usually require skin grafting, which can lead to color mismatch and visible scarring. Some surgeons prefer to reconstruct the auricle of each side separately, which prolongs the complete cycle of surgery and increases suffering of the patient. In this study, we introduce a modified technique using single expanded flaps without skin grafting to achieve simultaneous bilateral auricular reconstruction.

Methods

Between January 2012 and January 2017, a total of 54 patients with bilateral microtia underwent auricular reconstruction with expanded single flaps. Simultaneous bilateral auricular reconstruction was accomplished through 3 surgical stages. In the first stage, bilateral postauricular skin was expanded using 2 kidney-shaped tissue expanders. In the second stage, bilateral rib cartilage was harvested using minimal incisions, allowing 2 modified 3-layer frameworks to be fabricated. Each framework was then inserted into the pocket through the same incision with subsequent closure using 2-layer suture. In the third stage, the reconstructed ears were further trimmed, if necessary, and the lobules and tragus reconstructed. All the patients were followed up for 6 to 24 months.

Results

During follow-up, patients were satisfied with surgical outcome in terms of size, shape, location, detailing, and symmetry of the bilateral ears in more than 50 cases. Only 4 demonstrated postoperative complications. No skin necrosis, exposure of cartilage, or infection was observed or postoperative chest deformities.

Conclusions

Simultaneous bilateral auricular reconstruction using single expanded flaps combined with a modified 3-layer cartilage framework is an effective technique for patients with bilateral microtia.
Readability, Suitability, and Complexity of Online Resources for Lower Extremity Reconstruction
Authors: Hughes Christopher D. , Tran Bao Ngoc N. , Rinkinen Jacob , Lee Bernard T. , Iorio Matthew L.
Published: October 2018

Background

Surgical options for lower extremity reconstruction frequently include a decision between autologous free flap reconstruction and amputation. Patients rely on health education materials for information before making treatment decisions. This study evaluates the quality of online health information for lower extremity reconstruction.

Methods

We identified the top 10 Web sites for “leg amputation” and “leg free flap reconstruction.” Three validated tools were used to evaluate literacy demand of materials, including (1) the Simple Measure of Gobbledygook for readability; (2) the Peter Mosenthal and Irwin Kirsch readability formula for complexity of nonprose materials such as list, graphs, charts; and (3) the Centers for Disease Control and Prevention's Clear Communication Index (Index). Differences in mean between the 2 groups were compared using Student t test.

Results

Average Simple Measure of Gobbledygook reading grades approximated 12th-grade level and were similar between the 2 groups. This is above the recommended level of sixth-grade health literature. Complexity scores for nonprose materials of these groups were within recommended range and corresponded to very low complexity at a fourth- to seventh-grade level. The Centers for Disease Control and Prevention index was higher for amputation literature compared with free flap reconstruction (70% vs 54%), but the difference was not statistically significant.

Conclusions

Overall, online health resources for lower extremity amputation and free flap reconstruction do not meet the standard for quality and accessible health information. Free flap reconstruction resources are scarce and complex. Patients facing decisions about extremity reconstruction may not have appropriate online health resources available to them to make informed decisions.
Temporal Trends Associated With the Rise in Alcoholic Liver Disease-related Liver Transplantation in the United States
Authors: Cholankeril George , Gadiparthi Chiranjeevi , Yoo Eric R. , Dennis Brittany B. , Li Andrew A. , Hu Menghan , Wong Katherine , Kim Donghee , Ahmed Aijaz
Published: October 2018

Background

In the United States, alcoholic liver disease (ALD) has recently become the leading indication for liver transplantation.

Methods

Using the United Network for Organ Sharing registry, we examined temporal trends in adult liver transplant waitlist (WL) registrants and recipients with chronic liver disease (CLD) due to ALD from 2007 to 2016.

Results

From 2007 to 2016, ALD accounted for 20.4% (18 399) of all CLD WL additions. The age-standardized ALD WL addition rate was 0.459 per 100 000 US population in 2007; nearly doubled to 0.872 per 100 000 US population in 2016 and increased with an average annual percent change of 47.56% (95% confidence interval, 30.33% to 64.72%).The ALD WL addition rate increased over twofold among young (18-39 years) and middle-aged (40-59 years) adults during the study period. Young adult ALD WL additions presented with a higher severity of liver disease including Model for End-Stage Liver Disease score compared to middle aged and older adults (≥60 years). The number of annual ALD WL deaths readily rose from 2014 to 2016, despite an overall annual decline in all CLD WL deaths. Severe hepatic encephalopathy, low body mass index (<18.5) and diabetes mellitus were significant predictors for 1-year WL mortality.

Conclusions

Alcoholic liver disease–related WL registrations and liver transplantation have increased over the past decade with a disproportionate increase in young and middle-aged adults. These subpopulations within the ALD cohort need to be evaluated in future studies to improve our understanding of factors associated with these alarming trends.
The Transplant Index: A Novel Method to Predict Adult Liver Transplant Waitlist Outcomes
Authors: Kueht Michael , Bakhtiyar Syed Shahyan , Wu Jessie , Liu Hao , Chan Warren H. , Petrowsky Henrik , Riaz Irbaz B. , Cotton Ronald , Galvan Nhu Thao , O’Mahony Christine , Goss John , Rana Abbas
Published: October 2018

Background.

The field of transplantation is shifting outcome priorities from 1-year survival to more comprehensive metrics including transplant rate and waitlist mortality. Identifying disenfranchised candidates (high waitlist death risk, low transplantation chance) can be a focus to improve outcomes.

Methods.

Given the waitlist outcomes (continued waiting, death, and transplantation), we aimed to identify factors predicting the likelihood candidates would undergo transplant or death by performing multivariate competing risk analyses of 121 198 candidates in the United Network for Organ Sharing database. We incorporated these probabilities (likelihood of transplantation and waitlist death) into the Transplant Index (TI) to identify disenfranchised candidates (high likelihood of death, low likelihood of transplantation).

Results.

Half of the patients had low incidences of death and transplantation within 90 days (TI-inactive). The remaining were stratified into 10 groups within a predictive index, the TI. Low TI groups (TI 10, 20, 30) had 90-day transplant rates of 50.8%, 41.6%, and 39.8% respectively, and their respective 90-day death rates were 22.8%, 15.1%, and 10.9%. High TI groups (TI 80, 90, >90) had 90-day transplantation rates of 53.7%, 64.3%, and 73.9%, respectively, and 90-day death rates of 5.9%, 6.5%, and 6.7% respectively. As TI increased, the likelihood of transplantation increased and that of death decreased. Low-TI groups represent the disenfranchised candidates.

Conclusions.

The TI identifies disenfranchised candidates on the adult liver transplant waitlist. This is the subgroup that would benefit the most from efforts to increase access to transplantation.
The Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Inherited Diseases Is Influenced by HLA Match, Year of Transplantation, and Immunized Female Donor
Authors: Ringden Olle , Remberger Mats , Gustafsson Britt , Moretti Gianluca , Mattsson Jonas , Winiarski Jacek , Sadeghi Behnam
Published: October 2018

Background.

For many inborn errors of metabolism (IEM), allogeneic hematopoietic stem cell transplantation (HSCT) is the only cure.

Methods.

We report the outcome in 160 patients with inherited diseases, who were treated with HSCT in 3 decades. Median age was 3 years (range 0.1–63). Grafts were from matched related donors (MRDs, 56), matched unrelated donors (MUDs, 66), or HLA-mismatched donors (38).

Results.

Graft failure (GF) occurred in 26 patients (16%), severe acute graft-versus-host disease (GVHD) in 9 (6%), and chronic GVHD in 23 (12%). Ten-year survival was 64% before the year 2000 and 86% after that (P = 0.01). Ten-year survival for MRD grafts was 90%, as opposed to 79% for MUD grafts and 56% for HLA-mismatched grafts (P = 0.03). In multivariate analysis, GF was associated with having an HLA-mismatched donor (P < 0.05) or MUD (P = 0.015) and with reduced-intensity conditioning (P < 0.01). Death was associated with year of transplant (P = 0.015), having an HLA-mismatched donor (P < 0.001), and being a male recipient from an immune female donor (P = 0.05).

Conclusions.

The outcome after HSCT for IEM depends on HLA match, year and immune female donor.
Recommendations for Management and Treatment of Nonalcoholic Steatohepatitis
Authors: Ratziu Vlad , Ghabril Marwan , Romero-Gomez Manuel , Svegliati-Baroni Gianluca
Published: October 2018

The prevalence of nonalcoholic liver disease (NAFLD) is increasing worldwide in conjunction with the epidemic increase in obesity and metabolic risk factors. Consequently, NAFLD has become a leading indication for liver transplantation. Although genetic factors play an important role in the pathogenesis of NAFLD, detrimental lifestyle trends favoring a calorically unrestricted diet rich in carbohydrates and unsaturated fat, prolonged sedentary periods or limited physical activity have major metabolic implications. In aggregate these physiological dysregulations constitute the main risk factors for the metabolic syndrome and NAFLD. The cornerstone of the treatment of NAFLD, is lifestyle changes, including modifications to diet and physical activity, to reduce body weight and liver fat, however adherence is notoriously poor and the epidemic of NAFLD continues to grow unimpeded. In the face of this unmet clinical need, the pharmacologic therapy of NAFLD has been expanding as the varied mechanistic pathways of NAFLD are elucidated. Beyond these approaches to treating NAFLD, the prevention of other liver diseases is additionally important. Chief among these is alcoholic liver disease, and heavy use is detrimental irrespective of underlying NAFLD. However, the impact of mild to moderate alcohol use in patients with mild or nonadvanced forms NAFLD is undefined. This article summarizes the results of the International Liver Transplantation Society consensus meeting on NAFLD in liver transplantation. It describes the available evidence and provides consensus guidance on the lifestyle and pharmacologic therapies of NAFLD, and the consensus position on alcohol use in patients with NAFLD.
Risk Factors for Fellow Eye Involvement in Nonarteritic Anterior Ischemic Optic Neuropathy
Authors: Chang Melinda Y. , Keltner John L.
Published: October 2018

Background:

Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in individuals older than 50 years. Demographic, ocular, and systemic risk factors for NAION have been identified, and we sought to determine which, if any, of these factors also increase risk of NAION in the fellow eye.

Methods:

We performed a retrospective chart review of patients with “ischemic optic neuropathy” (based on International Classification of Disease [ICD] codes) seen at a single eye center between 2007 and 2017. Patients who met diagnostic criteria for unilateral NAION without fellow eye optic neuropathy at diagnosis were included. Demographic information, ocular comorbidities, and systemic diagnoses were recorded, in addition to whether the fellow eye developed NAION during the follow-up period. Univariate and multivariate Cox proportional hazard regression were used to calculate hazard ratios (HRs) for fellow eye involvement.

Results:

Three hundred eighteen patients were identified by ICD codes, and 119 were included in the study. Twenty-nine (24%) patients developed NAION in the fellow eye over the mean follow-up period of 3.6 years (range: 1 month–11 years). Significant risk factors for fellow eye NAION included the presence of bilateral optic disc drusen (ODD, HR 2.78, 95% confidence interval [CI] 1.12–6.90, P = 0.02) and noncompliance with continuous positive airway pressure (CPAP) in patients with moderate-to-severe obstructive sleep apnea (HR 4.50, 95% CI 1.79–11.3, P = 0.0015).

Conclusions:

Bilateral ODD and noncompliance with CPAP when indicated are associated with increased risk of NAION in the fellow eye. Patients with these risk factors should be counseled on the potentially devastating visual consequences of bilateral NAION, and compliance with CPAP should be stressed when appropriate.
Developmental tuning of mineralization drives morphological diversity of gill cover bones in sculpins and their relatives
Authors: Cytrynbaum Eli G. , Small Clayton M. , Kwon Ronald Y. , Hung Boaz , Kent Danny , Yan Yi-lin , Knope Matthew L. , Bremiller Ruth A. , Desvignes Thomas , Kimmel Charles B.
Published: October 2018

The role of osteoblast placement in skeletal morphological variation is relatively wellunderstood, but alternative developmental mechanisms affecting bone shape remain largely unknown. Specifically, very little attention has been paid to variation in later mineralization stages of intramembranous ossification as a driver of morphological diversity. We discover the occurrence of specific, sometimes large regions of nonmineralized osteoid within bones that also contain mineralized tissue. We show through a variety of histological, molecular, and tomographic tests that this “extended” osteoid material is most likely nonmineralized bone matrix. This tissue type is a significant determinant of gill cover bone shape in the teleostean suborder Cottoidei. We demonstrate repeated evolution of extended osteoid in Cottoidei through ancestral state reconstruction and test for an association between its presence and habitat differences among species. Through measurement of extended osteoid at various stages of gill cover development in species across the phylogeny, we gain insight into possible evolutionary developmental origins of the trait. We conclude that this finetuned developmental regulation of bone matrix mineralization reflects heterochrony at multiple biological levels and is a novel mechanism for the evolution of diversity in skeletal morphology. This research lays the groundwork for a new model in which to study bone mineralization and evolutionary developmental processes, particularly as they may relate to adaptation during a prominent evolutionary radiation of fishes.
A bacteria-derived tail anchor localizes to peroxisomes in yeast and mammalian cells
Authors: Lutfullahoğlu-Bal Güleycan , Bengisu Seferoğlu Ayşe , Keskinb Abdurrahman , Akdoğan Emel , Dunna Cory D.
Published: October 2018

Prokaryotes can provide new genetic information to eukaryotes by horizontal gene transfer (HGT), and such transfers are likely to have been particularly consequential at the dawn of eukaryogenesis. Since eukaryotes are highly compartmentalized, it is worthwhile to consider the mechanisms by which newly transferred proteins might reach diverse organellar destinations. Toward this goal, we have focused our attention upon the behavior of bacteria-derived tail anchors (TAs) expressed in the eukaryoteSaccharomyces cerevisiae. In this study, we report that a predicted membrane-associated domain of theEscherichia coliYgiM protein is specifically trafficked to peroxisomes in budding yeast, can be found at a pre-peroxisomal compartment (PPC) upon disruption of peroxisomal biogenesis, and can functionally replace an endogenous peroxisome-directed TA. Furthermore, the YgiM(TA) can also localize to peroxisomes in mammalian cells. Since the YgiM(TA) plays no endogenous role in peroxisomal function or assembly, this domain is likely to serve as an excellent tool toward illumination of the mechanisms by which TAs can travel to peroxisomes. Moreover, our findings emphasize the ease with which bacteria-derived sequences might target to organelles in eukaryotic cells following HGT, and we discuss the importance of flexible recognition of organelle targeting information during and after eukaryogenesis.
Comparative activity of Ceftriaxone, Ciprofloxacin and Gentamicin as a function of bacterial growth rate probed by Escherichia coli chromosome replication in the mouse peritonitis model
Authors: Schei Haugan Maria , Løbner-Olesen Anders , Frimodt-Møller Niels
Published: October 2018

Commonly used antibiotics exert their effect predominantly on rapidly growing bacterial cells, yet growth dynamics taking place during infection in a complex host environment remain largely unknown. Hence, means to measure in situ bacterial growth rate is essential to predict the outcome of antibacterial treatment. We have recently validated chromosome replication as readout for in situ bacterial growth rate during Escherichia coli infection in the mouse peritonitis model. By the use of two complementary methods (qPCR and fluorescence microscopy) for differential genome origin and terminus copy number quantification, we demonstrated the ability to track bacterial growth rate, both on a population average and on a single-cell level; from one single biological specimen. Here, we asked whether the in situ growth rate could predict antibiotic treatment effect during infection in the same model. Parallel in vitro growth experiments were conducted as proof-of-concept. Our data demonstrate that the activity of commonly used antibiotics Ceftriaxone and Gentamicin correlated with pre-treatment bacterial growth rate; both drugs performing better during rapid growth than during slow growth. Conversely, Ciprofloxacin was less sensitive to bacterial growth rate, both in a homogenous in vitro bacterial population and in a more heterogeneous in vivo bacterial population. The method serves as a platform to test any antibiotic’s dependency upon active in situ bacterial growth. Improved insight into this relationship in vivo could ultimately prove helpful in evaluating future antibacterial strategies.

Importance

Most antibiotics in clinical use exert their effect predominantly on rapidly growing bacterial cells, yet there is a lack of insight into bacterial growth dynamics taking place during infection in vivo. We have applied inexpensive and easily accessible methods for extraction of in situ bacterial growth rate from bacterial chromosome replication during experimental murine infection. This approach not only allows for a better understanding of bacterial growth dynamics taking place during the course of infection, but also serves as a platform to test the activity of different antibiotics as a function of pre-treatment in situ growth rate. The method has the advantage that bacterial growth rate can be probed from a single biological sample, with the potential for extension into clinical use in pre-treatment infected biological specimens. A better understanding of commonly used antibiotics’ level of dependency upon bacterial growth, combined with measurements of in situ bacterial growth rate in infected clinical specimens, could prove helpful in evaluating future antibacterial treatment regimens.
Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation in a lung transplant recipient
Authors: Arena Fabio , Marchetti Luca , De Angelis Lucia Henrici , Maglioni Enivarco , Contorni Martina , Iris Cassetta Maria , Novelli Andrea , Rossolini Gian Maria
Published: October 2018

Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation (ECMO) has not been previously studied. In this work we report on the ceftolozane and tazobactam plasmatic levels in a lung transplant recipient during ECMO, treated with ceftolozane-tazobactam (2g/1g, intravenously every 8 h, 1 h infusion) for a Pseudomonas aeruginosa pulmonary infection. Ceftolozane Cmax and Cmin, monitored during 96 hrs, remained above 60 and 20 μg/mL, respectively, with optimal drug exposure (100% %TMIC). Tazobactam levels were above 1.9 μg/mL.
Histologically derived fiber response functions for diffusion MRI vary across white matter fibers - an ex vivo validation study in the squirrel monkey brain
Authors: Schilling Kurt G , Gao Yurui , Stepniewska Iwona , Janve Vaibhav , Landman Bennett A , Anderson Adam W
Published: October 2018

Understanding the relationship between the diffusion-weighted MRI signal and the arrangement of white matter fibers is fundamental for accurate voxel-wise reconstruction of the fiber orientation distribution (FOD) and subsequent fiber tractography. Spherical deconvolution reconstruction techniques model the diffusion signal as the convolution of the FOD with a response function which represents the signal profile of a single fiber orientation. Thus, given the signal and a fiber response function, the FOD can be estimated in every imaging voxel by deconvolution. However, the selection of the appropriate response function remains relatively un-studied, and requires further validation. In this work, using 3D histologically-defined FODs and the corresponding diffusion signal from three ex vivo squirrel monkey brains, we derive the ground truth response functions. We find that the histologically-derived response functions differ from those conventionally used. Next, we find that response functions statistically vary across brain regions, which suggests that the practice of using the same kernel throughout the brain is not optimal. Additionally, response functions vary significantly across subjects. We show that different kernels lead to different FOD reconstructions, which in turn can lead to different tractography results depending on algorithmic parameters, with large variations in the accuracy of resulting reconstructions. Together, this suggests that there is room for improvement in estimating and understanding the relationship between the diffusion signal and the underlying FOD.
Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens
Authors: Manvich Daniel F. , Petko Alyssa K. , Branco Rachel C. , Foster Stephanie L. , Porter-Stransky Kirsten A. , Stout Kristen A. , Newman Amy H. , Miller Gary W. , Paladini Carlos A. , Weinshenker David
Published: October 2018

Background

The D3 receptor (D3R) has emerged as a promising pharmacotherapeutic target for the treatment of several diseases including schizophrenia, Parkinson’s disease, and substance use disorders. However, studies investigating the modulatory impact of D3R antagonism on dopamine neurotransmission or the effects drugs of abuse have produced mixed results, in part because D3R-targeted compounds often also interact with D2 receptors (D2R). The purpose of this study was to compare the consequences of selective D2R or D3R antagonism on the behavioral effects of cocaine in mice, and to identify the neurobiological mechanisms underlying their modulatory effects.

Methods

We characterized the effects of selective D2R or D3R antagonism in mice on 1) basal and cocaine-induced locomotor activity, 2) presynaptic dopamine release and clearance in the nucleus accumbens using ex vivo fast scan cyclic voltammetry, and 3) dopamine-mediated signaling in D1-expressing and D2-expressing medium spiny neurons using ex vivo electrophysiology.

Results

Pretreatment with the selective D2R antagonist L-741,626 attenuated, while pretreatment with the selective D3R antagonist PG01037 enhanced, the locomotor-activating effects of acute and repeated cocaine administration. While both antagonists potentiated cocaine-induced increases in presynaptic DA release, D3R blockade uniquely facilitated DA-mediated excitation of D1-expressing medium spiny neurons in the nucleus accumbens.

Conclusions

Selective D3R antagonism potentiates the behavioral-stimulant effects of cocaine in mice, an effect that is in direct opposition to that produced by selective D2R antagonism or nonselective D2-like receptor antagonists, likely by facilitating D1-mediated excitation in the nucleus accumbens. These findings provide important insights into the neuropharmacological actions of D3R antagonists on mesolimbic dopamine neurotransmission.
Aerodynamic characteristics of helicopter engine side air intakes
Authors: Knoth Florian , Breitsamter Christian
Published: October 2018

Purpose

Aerodynamic characteristics of engine side air intakes for a lightweight helicopter are investigated aiming to achieve an efficient engine airframe integration.

Design/methodology/approach

On a novel full-scale model of a helicopter fuselage section, a comprehensive experimental data set is obtained by wind tunnel testing. Different plenum chamber types along with static side intake and semi-dynamic side intake configurations are considered. Engine mass flow rates corresponding to the power requirements of realistic helicopter operating conditions are reproduced. For a variety of freestream velocities and mass flow rates, five-hole pressure probe data in the aerodynamic interface plane and local surface pressure distributions are compared for the geometries.

Findings

In low-speed conditions, unshielded, sideways facing air intakes yield lowest distortion levels and total pressure losses. In fast forward flight condition, a forward-facing intake shape is most beneficial. Additionally, the influence of an intake grid and plenum chamber splitter is evaluated.

Originality/value

The intake testing approach and the trends found can be applied to other novel helicopter intakes in early development stages to improve engine airframe integration and decrease development times.
Comparison of flutter calculation methods based on ground vibration test result
Authors: Chajec Wojciech
Published: October 2018

Purpose

A low-cost but credible method of low-subsonic flutter analysis based on ground vibration test (GVT) results is presented. The purpose of this paper is a comparison of two methods of immediate flutter problem solution: JG2 – low cost software based on the strip theory in aerodynamics (STA) and V-g method of the flutter problem solution and ZAERO I commercial software with doublet lattice method (DLM) aerodynamic model and G method of the flutter problem solution. In both cases, the same sets of measured normal modes are used.

Design/methodology/approach

Before flutter computation, resonant modes are supplied by some non-measurable but existing modes and processed using the author’s own procedure. For flutter computation, the modes are normalized using the aircraft mass model. The measured mode orthogonalization is possible. The flutter calculation made by means of both methods are performed for the MP-02 Czajka UL aircraft and the Virus SW 121 aircraft of LSA category.

Findings

In most cases, both compared flutter computation results are similar, especially in the case of high aspect wing flutter. The Czajka T-tail flutter analysis using JG2 software is more conservative than the one made by ZAERO, especially in the case of rudder flutter. The differences can be reduced if the proposed rudder effectiveness coefficients are introduced.

Practical implications

The low-cost methods are attractive for flutter analysis of UL and light aircraft. The paper presents the scope of the low-cost JG2 method and its limitations.

Originality/value

In comparison with other works, the measured generalized masses are not used. Additionally, the rudder effectiveness reduction was implemented into the STA. However, Niedbal (1997) introduced corrections of control surface hinge moments, but the present work contains results in comparison with the outcome obtained by means of the more credible software.
Museums and digital era: preserving art through databases
Authors: Rivero Moreno Luis D.
Published: October 2018

Purpose

Digital language has meant a revolution in the methods of production, distribution and conservation of contemporary art. The purpose of this paper is to reflect on the new status of museums within the digital age. Works using new media must be understood as spaces of non-hierarchical communication where an artist’s role is diluted and the public becomes a user that completes an open process. Therefore, the function of the museum is challenged, being no longer a moral authority or a place of storing physical works. Because of its instability and obsolescence, the only valid method for the conservation of digital art is permanence through change.

Design/methodology/approach

This research contrasts the theoretical material emerged in the past years related to the characteristic of new media to the practical work of conservation of digital pieces made by the new generation of museums and cultural centres. In addition, the fresh material offered by the Web itself allows analyzing the virtual activity of the museums themselves and the new platforms (online labs, databases, websites and blogs) arisen in the past decades. The latter are perfect examples of the new paths opened by the digital contemporary technology offering collective sites of communication in real time.

Findings

The preservation of digital and intangible heritage is understood as a form of development of a collective memory that can help in the understanding of our age in the future. In this way, the goals and the responsibilities are common; citizens are required to keep an active culture that is no more a culture of the accumulation and concentration by a minority. In present context, there is a new possibility, maybe for the first time in history, of achieving a new narrative really democratized and decentralized through the new ways of interacting and sharing information offers by digital media.

Social implications

The urgency of getting an open and free access to information and technology is part of the idiosyncratic of digital art. There is a real aim of generating alternative spaces of knowledge serving public interest, being apart from the economic and political interests of large corporations. In this respect, the role of the museum will be controversial. First of all, as an institution originally created to impose power and moral authority by the governments.

Originality/value

Museums remains as the main artistic institution nowadays. However, they are in a difficult position as a traditional space for preserving and exhibiting art. That is why, they are adapting themselves to the new digital context helped by offering practical databases and updated information on their collections via websites and social networks.
Behaviour of single-phase self-excited induction generator during short-circuit at terminals
Authors: Makowski Krzysztof , Leicht Aleksander
Published: October 2018

Purpose

The purpose of this paper is to present analysis of short-circuit transients in a single-phase self-excited induction generator (SP-SEIG) for different capacitor topologies.

Design/methodology/approach

The paper presents field analysis of the short-circuit problem in the SP-SEIG on the base of two-dimensional field-circuit model of the generator.

Findings

The carried-out field computations of the tested SP-SEIG show that the self-excited induction generator is intrinsically protected from the results of sudden short-circuit, as output voltage and current drop rapidly to zero. Short-circuit is a problem when a series capacitor is used to improve output voltage regulation. Experimental results show that re-excitation of the generator is possible after the short-circuit is removed.

Originality/value

The originality of the paper is the presented analysis of short-circuit transients at terminals of SP-SEIG. A finite elements method-based field circuit model was used. The simulation results were validated by the measurements conducted on a laboratory test setup.
Investigating health information systems-induced errors
Authors: Yusof Maryati , Sahroni Mohamad Norzamani
Published: October 2018

Purpose

The purpose of this paper is to present a review of health information system (HIS)-induced errors and its management. This paper concludes that the occurrence of errors is inevitable but it can be minimised with preventive measures. The review of classifications can be used to evaluate medical errors related to HISs using a socio-technical approach. The evaluation could provide an understanding of errors as a learning process in managing medical errors.

Design/methodology/approach

A literature review was performed on issues, sources, management and approaches to HISs-induced errors. A critical review of selected models was performed in order to identify medical error dimensions and elements based on human, process, technology and organisation factors.

Findings

Various error classifications have resulted in the difficulty to understand the overall error incidents. Most classifications are based on clinical processes and settings. Medical errors are attributed to human, process, technology and organisation factors that influenced and need to be aligned with each other. Although most medical errors are caused by humans, they also originate from other latent factors such as poor system design and training. Existing evaluation models emphasise different aspects of medical errors and could be combined into a comprehensive evaluation model.

Research limitations/implications

Overview of the issues and discourses in HIS-induced errors could divulge its complexity and enable its causal analysis.

Practical implications

This paper helps in understanding various types of HIS-induced errors and promising prevention and management approaches that call for further studies and improvement leading to good practices that help prevent medical errors.

Originality/value

Classification of HIS-induced errors and its management, which incorporates a socio-technical and multi-disciplinary approach, could guide researchers and practitioners to conduct a holistic and systematic evaluation.
A strategic and good governance perspective on handling patient complaints
Authors: Ryynänen Sanna Pauliina , Harisalo Risto
Published: October 2018

Purpose

The patient complaint is one of the main procedures of exercising patient’s rights in the Finnish health care system. Such complaints typically concern the quality of care and/or patient safety. The purpose of this paper is to examine the types of patient complaints received by a specialized medical care organization and the kinds of responses given by the organization’s personnel. The organization’s strategy and good governance principles provide the framework for understanding the organization’s action.

Design/methodology/approach

This study’s data comprise patient complaints and the responses from personnel of a specialized medical care organization from the start of 2012 to the end of January 2014. The data were analyzed through qualitative data analysis.

Findings

The results show many unwanted grievances, but also reveal the procedures employed to improve health care processes. The results are related to patients’ care experiences, provision of information, personnel’s professional skills and the approach to patient complaints handling. The integrative result of the analysis was to find consensus between the patients’ expectations and personnel’s evaluation of patients’ needs.

Originality/value

Few prior studies have examined patient complaints related to both strategy and good governance. Patient complaints were found to have several confluences with an organization’s strategic goals, objectives and good governance principles. The study recommends further research on personnel procedures for patient complaints handling, with a view to influencing strategic planning and implementation of strategies of organizations.
A conceptual framework for the adoption of Islamic banking in a pluralistic-secular nation
Authors: Ezeh Precious Chikezie , Nkamnebe Anayo D.
Published: October 2018

Purpose

Islamic banking is an emerging product in Nigeria; it has evolved as a new reality in the Nigerian financial scene since 2011. Thus, the purpose of this paper is to propose a conceptual framework for the study of Islamic banking adoption behavior among bank customers in Nigeria.

Design/methodology/approach

This study is a literature and theoretical review of past studies to develop a comprehensive framework for the study of Islamic banking adoption behavior in Nigeria.

Findings

In this conceptual study, the researcher identified 12 independent variables, namely, relative advantage, compatibility, complexity, observability, trialability, uncertainty, promotional efforts, awareness, customer involvement, perceived information quality, profit/loss sharing and religiosity, as suitable variables for the study of Islamic bank adoption in Nigeria.

Practical implications

As Islamic banking is an innovative and unique product, which differs from conventional banking, it is hopeful that upon validating the framework, it will provide useful insight on the adoption behavior of Islamic bank customers in Nigeria.

Social implications

This study will be useful to Islamic banks in gaining and maintaining their existing customer, and policymakers, regulators and other relevant stakeholders will be able to strategize in accordance with their respective assignments toward the development and growth of the Nigerian financial industry.

Originality/Value

Most previous studies concentrated on product attributes of innovation adoption. But, this current study inculcated the consumers’ attitude and perception toward adoption of Islamic banking. Thus, the authors then propose several factors that can influence adoption of Islamic banking in Nigeria.
Optimizing carbon storage and biodiversity co‐benefits in reforested riparian zones
Authors: Dybala Kristen E. , Steger Kristin , Walsh Robert G. , Smart David R. , Gardali Thomas , Seavy Nathaniel E.
Published: October 2018

Climate change and biodiversity loss are two global challenges that can be addressed simultaneously through reforestation of previously cleared land. However, carbon markets can encourage reforestations that focus on maximizing carbon storage, potentially at the expense of biodiversity conservation.

To identify opportunities to optimize reforestation design and management to meet both goals, we examined the forest stand features associated with carbon stocks in biomass and soil, as well as bird abundance and diversity, in remnant and restored riparian forest stands in central California, U.S.A.

Within three decades of reforestation, both planted and naturally regenerating riparian forest stands provided significantly greater carbon storage and avian biodiversity benefits compared to baseline conditions. They were also similar to a remnant riparian forest stand.

We identified a synergy between carbon storage and biodiversity benefits in their positive associations with understorey cover, but we also identified a trade‐off in their relationships to forest stand density. Biomass carbon stocks were strongly positively related to stand density, while bird density and diversity suffered at the highest stand densities.

The variability in understorey cover across forest stands indicates an opportunity for further enhancement of carbon and biodiversity benefits in areas where understorey cover is low, while the variability in stand density suggests an opportunity to re‐examine reforestation goals and consider thinning to achieve those goals.

Synthesis and applications. We identified synergies and trade‐offs between carbon storage and biodiversity in their relationships to forest stand features, indicating opportunities to optimize reforestation design and management to achieve multiple goals. Our approach can be adapted to other reforestation efforts intended to simultaneously address the global challenges of climate change and biodiversity loss.