bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA Methylation of Mouse Testes, Cardiac and Lung Tissue During Long-Term Microgravity Simulation
Authors: Loktev Sergey S. , Ogneva Irina V.
Published: May 2019

Under microgravity, the gene expression levels vary in different types of cells; however, the reasons for this have not been sufficiently studied. The aim of this work was to evaluate the methylation of CpG islands in the promoter regions of the genes encoding some cytoskeletal proteins, the total methylation and 5 hmC levels, and the levels of enzymes that regulate these processes in the testes, heart, and lungs in mice after a 30-day microgravity modeling by antiorthostatic suspension and after a subsequent 12-hour recovery as well as in the corresponding control group and identical groups treated with essential phospholipids. The obtained results indicate that under modeling microgravity in the examined tissues a decrease of cytoskeletal gene expression (mainly in the heart and lungs tissues) correlated with an increase in the CpG islands methylation and an increase of the expression (mainly in the testes tissue) – with a decrease of the CpG-methylation, despite of the fact that in the examined tissues took place a decrease of the content methylases and demethylases. But the deacetylase HDAC1 content increased in the heart and lungs tissues and decreased in the testes, letting us suggest its participation in the regulation of the methylation level under microgravity conditions.
Alteration of erythrocyte membrane polyunsaturated fatty acids in preterm newborns with retinopathy of prematurity
Authors: Pallot Charlotte , Mazzocco Julie , Meillon Cyril , Semama Denis S. , Chantegret Corinne , Ternoy Ninon , Martin Delphine , Donier Aurélie , Gregoire Stéphane , Creuzot-Garcher Catherine P. , Bron Alain M. , Bretillon Lionel , Acar Niyazi
Published: May 2019

Extremely preterm infants are at high risk for retinopathy of prematurity (ROP), a potentially blinding disease characterized by abnormalities in retinal vascularization. Whereas animal studies revealed that n-3 polyunsaturated fatty acids (PUFAs) may be of benefit in preventing ROP, human studies conducted on preterm infants during the 1st weeks of life showed no association between blood n-3 PUFA bioavailability and ROP incidence and/or severity, probably because of the influence of nutrition on the lipid status of infants. In the OmegaROP prospective cohort study, we characterized the erythrocyte concentrations of PUFAs in preterm infants aged less than 29 weeks gestational age (GA) without any nutritional influence. We show that GA is positively associated with the erythrocyte n-6 to n-3 PUFA ratio, and particularly with the ratio of arachidonic acid (AA) to docosahexaenoic acid (DHA), in infants with ROP. A time-dependent accumulation of AA at the expense of DHA seems to occur in utero in erythrocytes of preterm infants who will develop ROP, thus reinforcing previous data on the beneficial properties of DHA on this disease. In addition, preliminary data on maternal erythrocyte membrane lipid concentrations suggest modifications in placental transfer of fatty acids. Documenting the erythrocyte AA to DHA ratio at birth in larger cohorts might be useful to set up new prognostic factors for ROP.
Enhanced osteogenic proliferation and differentiation of human adipose-derived stem cells on a porous n-HA/PGS-M composite scaffold
Authors: Wang Yaozong , Sun Naikun , Zhang Yinlong , Zhao Bin , Zhang Zheyi , Zhou Xu , Zhou Yuanyuan , Liu Hongyi , Zhang Ying , Liu Jianguo
Published: May 2019

This study explored the applicability, cellular efficacy, and osteogenic activities of porous nano-hydroxyapatite/Poly (glycerol sebacate)-grafted maleic anhydride (n-HA/PGS-g-M) composite scaffolds. Nuclear magnetic resonance (NMR) analyses indicated that approximately 43% of the hydroxide radicals in PGS were displaced by maleic anhydride. Resonance bands at 1036 cm−1 occurred in scaffolds containing nHA powders, and peak areas increased when n-HA weight increased in PGS-M-n-HA-0.4, PGS-M-n-HA-0.5, and PGS-M-n-HA-0.6 scaffolds. The n-HA/PGS-g-M composite scaffolds exhibited porous microstructure with average pore size of 150–300 µm in scanning electron microscopy (SEM) analysis. Differential scanning calorimetry (DSC) identified the glass transition temperature (Tg) as −25–30 °C, indicative of quality resilience. The modulus of compressibility increased when n-HA content increased. Interestingly, viability of human adipose-derived stem cells (hADSCs) in vitro and expression of the osteogenic related genes RUNX2, OCN, and COL1A1 was enhanced in the n-HA/PGS-g-M composite scaffolds compared to those factors observed in PGS-g-M scaffolds. Finally, simulated body fluid (SBF) tests indicated more apatite deposits on the surface of n-HA/PGS-g-M scaffolds compared to PGS-g-M scaffolds. Overall, porous n-HA/PGS-g-M composite scaffolds possessed acceptable biocompatibility and mechanical properties, and they stimulated hADSC cell proliferation and differentiation. Given these qualities, the composite scaffolds have potential applications in bone tissue engineering.
Role of deleterious single nucleotide variants in the coding regions of TNFAIP3 for Japanese autoimmune hepatitis with cirrhosis
Authors: Higuchi Takashi , Oka Shomi , Furukawa Hiroshi , Nakamura Minoru , Komori Atsumasa , Abiru Seigo , Hashimoto Satoru , Shimada Masaaki , Yoshizawa Kaname , Kouno Hiroshi , Naganuma Atsushi , Ario Keisuke , Kaneyoshi Toshihiko , Yamashita Haruhiro , Takahashi Hironao , Makita Fujio , Yatsuhashi Hiroshi , Ohira Hiromasa , Migita Kiyoshi
Published: May 2019

Autoimmune hepatitis (AIH) is an autoimmune liver disease and cirrhosis is sometimes complicated with AIH at diagnosis, influencing its prognosis.TNFAIP3gene encodes A20, an inhibitor of nuclear factor-κB pathway, and is a susceptibility gene for autoimmune diseases. We investigated deleterious variants in the coding regions ofTNFAIP3gene of Japanese AIH patients or those with cirrhosis. The deleterious variants in the coding regions ofTNFAIP3gene were analyzed by the cycle sequencing method and the frequencies of deleteriousTNFAIP3alleles of AIH or AIH with cirrhosis were compared with those of Japanese controls. The deleterious alleles inTNFAIP3were not associated with AIH. A significant association was shown for the deleterious alleles inTNFAIP3(P = 0.0180, odds ratio (OR) 4.28, 95% confidence interval (CI) 1.53–11.95) with AIH with cirrhosis at presentation. The serum IgM levels in AIH patients with deleterious alleles inTNFAIP3were tended to be lower than those without (P = 0.0152,Q = 0.1216). The frequency of deleterious alleles inTNFAIP3was higher in the AIH subset without theDRB1risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55–16.74). The deleterious alleles inTNFAIP3were associated with AIH with cirrhosis.
Polyamine-induced, chiral expression from liquid crystalline peptide nanofilaments to long-range ordered nanohelices
Authors: Wang Yuefei , Feng Yaoayo , Yang Xin , Wang Jiahui , Qi Wei , Yang Xuejiao , Liu Xiao , Xing Qiguo , Su Rongxin , He Zhimin
Published: May 2019

Polyamines and electrostatic interactions could induce the condensation of liquid-crystalline peptide nanofilaments into long-range ordered chiral nanostructures.
The human body burden of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in residents’ human milk from Guangdong Province, China
Authors: Huang Rui , Wang Ping , Zhang Jianqing , Chen Shaowei , Zhu Pan , Huo Weilun , Jiang Yousheng , Chen Zihui , Peng Jiewen
Published: May 2019

Concentrations of PCDD/Fs and DL-PCBs were determined to evaluate the human body burden of dioxin-like compounds.
Integrating comprehensive two-dimensional gas chromatography mass spectrometry and parallel two-dimensional liquid chromatography mass spectrometry for untargeted metabolomics
Authors: Prodhan Md Aminul Islam , Shi Biyun , Song Ming , He Liqing , Yuan Fang , Yin Xinmin , Bohman Patrick , McClain Craig J. , Zhang Xiang
Published: May 2019

The diverse characteristics and large number of entities make metabolite separation challenging in metabolomics.
Synthesis of catalytically active bimetallic nanoparticles within solution-processable metal–organic-framework scaffolds
Authors: Zhang Wendi , Wang Shuping , Yang Fei , Yang Zhijie , Wei Huiying , Yang Yanzhao , Wei Jingjing
Published: May 2019

Bimetallic alloy nanoparticles are synthesized by in situ reduction of mixed metal ions inside CD-MOFs.
From BTO2− to HBTO− insensitive energetic salt: a route to boost energy
Authors: Xu Yuangang , Li Dongxue , Lin Qiuhan , Wang Pengcheng , Lu Ming
Published: May 2019

A promising strategy was utilized to boost the detonation performance of insensitive energetic salts.
Depletion of atmospheric organic trace gases due to their uptake by an ensemble of aqueous aerosols evolving via concurrent condensation and chemical aging
Authors: Djikaev Yuri S. , Ruckenstein Eli
Published: May 2019

In the framework of classical nucleation theory (CNT), we demonstrate that an ensemble of aqueous hydrophilic–hydrophobic organic droplets, containing both soluble and insoluble surfactants and evolving via concurrent condensation and chemical aging, may deplete the surrounding air of low-volatility organic trace gases and thus noticeably decrease their saturation ratios.
A theoretical analysis of the structure and properties of B26H30 isomers. Consequences to the laser and semiconductor doping capabilities of large borane clusters
Authors: Macháček Jan , Francés-Monerris Antonio , Karmodak Naiwrit , Roca-Sanjuán Daniel , Fanfrlík Jindřich , Londesborough Michael G. S. , Hnyk Drahommír , Jemmis Eluvathingal D.
Published: May 2019

The most stable isomer B26H30 with its predicted applications.
The surface chemistry of metal–organic frameworks and their applications
Authors: Forgan Ross S.
Published: May 2019

Recent highlights in the surface modification of metal–organic frameworks, from new functionalization protocols to visualisation and application, are discussed.
Structural and chemical properties of half-sandwich rhodium complexes supported by the bis(2-pyridyl)methane ligand
Authors: Lionetti Davide , Day Victor W. , Blakemore James D.
Published: May 2019

The bis(2-pyridyl)methane ligand can support [Cp*Rh] complexes (Cp* = pentamethylcyclopentadienyl) in the Rh(iii) and Rh(ii) oxidation states. Structural and reactivity studies demonstrate significant differences between these complexes and notable analogues bearing the related dimethylbis(2-pyridyl)methane ligand.
The concept of essential use for determining when uses of PFASs can be phased out
Authors: Cousins Ian T. , Goldenman Gretta , Herzke Dorte , Lohmann Rainer , Miller Mark , Ng Carla A. , Patton Sharyle , Scheringer Martin , Trier Xenia , Vierke Lena , Wang Zhanyun , DeWitt Jamie C.
Published: May 2019

The concept of essential use is developed and applied to various uses of PFASs to determine the feasibility of elimination or substitution in each use category.
Effect of citrus peel extracts on the cellular quiescence of prostate cancer cells
Authors: Shammugasamy Balakrishnan , Valtchev Peter , Dong Qihan , Dehghani Fariba
Published: May 2019

Citrus peel extracts as a functional food for cancer recurrence prevention.
Lipase-catalysed synthesis of palm oil-omega-3 structured lipids
Authors: Xia Qiuyu , Akanbi Taiwo O. , Li Rui , Wang Bo , Yang Wenrong , Barrow Colin J.
Published: May 2019

Candida antarctica lipase A was applied to selectively remove saturated fatty acids from palm oil. Rhizomucor miehei lipase was then used to add EPA or ALA into the partially hydrolyzed palm oil to produce new palm oil structured lipids containing approximately 30% omega-3 fatty acids.
A novel purification method for high precision measurement of Ni isotopes by double spike MC-ICP-MS
Authors: Wu Guangliang , Zhu Jian-Ming , Wang Xiangli , Han Guilin , Tan Decan , Wang Shui-Jiong
Published: May 2019

An inexpensive, simple and low-blank Ni purification method is presented for the high-precision measurement of Ni isotopes by double-spike MC-ICP-MS.
Continuous micellar electrokinetic focusing of neutral species driven by ion concentration polarization
Authors: Berzina Beatrise , Anand Robbyn K.
Published: May 2019

Here, we demonstrate continuous electrokinetic focusing and separation of uncharged compounds by their partition into an ionic micellar phase.
Synthesis of aromatic imide tetramers relevant to organic electronics by direct (hetero)arylation
Authors: Welsh T. A. , Payne A.-J. , Welch G. C.
Published: May 2019

We report six tetrameric compounds synthesized via direct (hetero)arylation methods based on phthalimide, naphthalimide, and perylene diimide end groups with fused thiophene cores.
Probing the structures and electronic properties of anionic and neutral BiAun−1,0 (n = 2–20) clusters: a pyramid-like BiAu13 cluster
Authors: Zhang Shuai , Zhang Yu , Yang Xing Qiang , Li Gen Quan , Lu Zhi Wen
Published: May 2019

The geometric structures and electronic properties of bismuth-doped gold clusters, BiAun−1,0 (n = 2–20), are studied via a combination of the Crystal structure AnaLYsis by Particle Swarm Optimization structure prediction software and the density functional theory approach.
Detection of resistance protein A (MxA) in paper-based immunoassays with surface enhanced Raman spectroscopy with AuAg nanoshells
Authors: Russo Lorenzo , Sánchez-Purrà Maria , Rodriguez-Quijada Cristina , Leonardo Brianna M. , Puntes Victor , Hamad-Schifferli Kimberly
Published: May 2019

Hollow AuAg nanoshells enable Surface Enhanced Raman Spectroscopy readout of a paper immunoassay for myxovirus protein A (MxA), a biomarker that can distinguish viral vs. bacterial infections.
Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore
Authors: Sun Yunxiang , Kakinen Aleksandr , Zhang Chi , Yang Ye , Faridi Ava , Davis Thomas P. , Cao Weiguo , Ke Pu Chun , Ding Feng
Published: May 2019

Featuring small sizes, caged structures, low cytotoxicity and the capability to cross biological barriers, fullerene hydroxy derivatives named fullerenols have been explored as nanomedicinal candidates for amyloid inhibition.
A universal discoidal nanoplatform for the intracellular delivery of PNAs
Authors: Tahmasbi Rad Armin , Malik Shipra , Yang Lin , Oberoi-Khanuja Tripat Kaur , Nieh Mu-Ping , Bahal Raman
Published: May 2019

Peptide nucleic acids (PNAs) have gained considerable attention due to their remarkable potential in gene editing and targeting-based strategies.
The selectivity of poly(2-vinylpyridine-block-methyl methacrylate) copolymer films: an AFM study
Authors: Rahim Sana , Bhayo Adnan Murad , Siddiqui Ghayas Uddin , Maalik Aneela , Memon Najma , Shah Muhammad Raza , Malik Muhammad Imran
Published: May 2019

In this study, the surface morphologies of poly(2-vinyl pyridine-block-methyl methacrylate), P(2VP-MMA), copolymer films were analyzed by atomic force microscopy.
Ethylene glycol coated nanoceria protects against oxidative stress in human lens epithelium
Authors: Hanafy Belal I. , Cave Gareth W. V. , Barnett Yvonne , Pierscionek Barbara
Published: May 2019

Nanoceria (<5 nm), stabilised with ethylene glycol, protects human lens epithelium from oxidative stress and exhibits multicoloured photoluminescence.
A glucose biosensor based on the immobilization of glucose oxidase and Au nanocomposites with polynorepinephrine
Authors: Liu Yang , Nan Xu , Shi Wei , Liu Xin , He Zi , Sun Yanan , Ge Dongtao
Published: May 2019

The PNE/GOD/AuNPs@PNE/Au electrode exhibited a low Michaelis–Menten constant, a fast response to glucose, outstanding anti-interference ability and high sensitivity.
Effect of vanadium pentoxide concentration in ZnO/V2O5 nanostructured composite thin films for toluene detection
Authors: Nagaraju P. , Vijayakumar Y. , Reddy M. V. Ramana , Deshpande U. P.
Published: May 2019

ZnO/V2O5 nanocomposite thin films were synthesised by the spray pyrolysis technique with optimised deposition parameters by varying the concentration of vanadium pentoxide.
Interrogating solar photoelectrocatalysis on an exfoliated graphite–BiVO4/ZnO composite electrode towards water treatment
Authors: Orimolade Benjamin O. , Koiki Babatunde A. , Zwane Busisiwe N. , Peleyeju Gbenga M. , Mabuba Nonhlangabezo , Arotiba Omotayo A.
Published: May 2019

Band alignment between ZnO and BiVO4 on exfoliated graphite (EG) support.
High-aspect-ratio mushroom-like silica nanopillars immersed in air: epsilon-near-zero metamaterials mediated by a phonon-polaritonic anisotropy
Authors: Ito Kota , Yamada Yuri , Miura Atsushi , Iizuka Hideo
Published: May 2019

High-aspect-ratio mushroom-like silica nanopillars fabricated from self-assembly of block-copolymers exhibit a uniaxial epsilon-near-zero response in the mid-infrared range.
Influence of the substituent D/A at the 1,2,3-triazole ring on novel terpyridine derivatives: synthesis and properties
Authors: Zych Dawid , Slodek Aneta , Zimny Dżastin , Golba Sylwia , Malarz Katarzyna , Mrozek-Wilczkiewicz Anna
Published: May 2019

The change in the substituents (D/A) at the 1,2,3-triazole ring of terpyridine derivatives shows a strong influence on the photophysical and biological properties of these derivatives.
Drug-eluting contact lens containing cyclosporine-loaded cholesterol-hyaluronate micelles for dry eye syndrome
Authors: Mun Jonghwan , Mok Jee won , Jeong Sanghoon , Cho Seonghwi , Joo Choun-Ki , Hahn Sei Kwang
Published: May 2019

A cholesterol-hyaluronate (C-HA) micelle embedded contact lens was developed for efficient hydrophobic drug loading and long-term controlled drug delivery.
Exploring the dual functionality of an ytterbium complex for luminescence thermometry and slow magnetic relaxation
Authors: Brunet Gabriel , Marin Riccardo , Monk Melissa-Jane , Resch-Genger Ute , Gálico Diogo A. , Sigoli Fernando A. , Suturina Elizaveta A. , Hemmer Eva , Murugesu Muralee
Published: May 2019

A combined experimental and theoretical approach reveals the intricacies related to an YbIIIcomplex, which functions dually as a SMM and a luminescent thermometer.
Selective C–F bond carboxylation of gem-difluoroalkenes with CO2 by photoredox/palladium dual catalysis
Authors: Zhu Chuan , Zhang Yu-Feng , Liu Ze-Yao , Zhou Lu , Liu Haidong , Feng Chao
Published: May 2019

A catalytic C(sp2)–F bond carboxylation with CO2 is reported; the reaction is enabled by dual photoredox/palladium catalysis and involves a crucial fluoroalkenyl radical intermediate.
Viscoelastic response ofEscherichia colibiofilms to genetically altered expression of extracellular matrix components
Authors: Horvat Maruša , Pannuri Archana , Romeo Tony , Dogsa Iztok , Stopar David
Published: May 2019

How the viscoelastic properties of the extracellular matrix affect the various biological functions conferred by biofilms is an important question in microbiology.
Carbon nanotube-linked hollow carbon nanospheres doped with iron and nitrogen as single-atom catalysts for the oxygen reduction reaction in acidic solutions
Authors: Li Jin-Cheng , Cheng Min , Li Tao , Ma Lu , Ruan Xiaofan , Liu Dong , Cheng Hui-Ming , Liu Chang , Du Dan , Wei Zidong , Lin Yuehe , Shao Minhua
Published: May 2019

A three-dimensional structure consisting of atomically dispersed Fe, N-doped hollow carbon nanospheres linked by carbon nanotubes was engineered as an electrocatalyst showing a high activity for oxygen reduction reaction.
Highly stretchable electromagnetic interference (EMI) shielding segregated polyurethane/carbon nanotube composites fabricated by microwave selective sintering
Authors: Feng Dong , Xu Dawei , Wang Qingqing , Liu Pengju
Published: May 2019

Microwave selective sintering is a green and efficient strategy to construct a segregated conductive network.
Elevated microRNA-145 inhibits the development of oral squamous cell carcinoma through inactivating ERK/MAPK signaling pathway by down-regulating HOXA1
Authors: Ding Junhai , Sun Dubin , Xie Pengfeng
Published: May 2019

Background: Oral cancer is one of the most frequent solid cancers worldwide, and oral squamous cell carcinoma (OSCC) constitutes approximately 90% of oral cancers. The discovery of reliable prognostic indicators would be a potential strategy for OSCC treatment. In the present study, we aim to explore the underlying mechanism by which microRNA-145 (miR-145) affected OSCC. Methods: Forty-eight patients diagnosed with OSCC were enrolled to obtain the OSCC tissues and adjacent normal tissues. The targeting relationship between miR-145 and Homeobox A1 (HOXA1) was verified. In order to assess the effects of miR-145 in OSCC and the detailed regulatory mechanism, the SCC-9 cell line was adopted, in which expression of miR-145 and HOXA1 were altered by transfection. Then, a series of in vitro and in vivo experiments were performed to evaluate the cell viability, migration, invasion, and tumor growth. Results: miR-145 was poorly expressed and HOXA1 was highly expressed in OSCC. HOXA1 was verified as a target of miR-145 to mediate the activation of the extracellular signal-regulated kinase/mitogen activated protein kinase (ERK/MAPK) signaling pathway. In the circumstance of miR-145 elevation or HOXA1 depletion, the SCC-9 cell line manifested with inhibited cell viability, invasion, and migration in vitro, coupled with reduced tumor growth in vivo, with a decreased expression of ERK/MAPK signaling pathway-related genes/proteins. Conclusion: These findings suggested that miR-145 can inhibit HOXA1 to inactivate the ERK/MAPK signaling pathway, thereby suppressing OSCC cell proliferation, migration, and invasion to further inhibit the development of OSCC, highlighting a novel therapeutic target for the OSCC treatment.
Yi-qi-yang-yin-tian-sui-fang enhances cisplatin-induced tumor eradication and inhibits interleukin-7 reduction in non-small cell lung cancer
Authors: Ke Bin , Wu Xinlin , Yang Qiong , Huang Yuanyuan , Wang Fang , Gong Yuxin , Liu Junfang , Shi Lin
Published: May 2019

Traditional Chinese Medicine (TCM) has been recognized to be conducive to enhancing the efficiency and reducing the side effects in the whole course of cancer treatment. The mechanisms of TCM/chemotherapy combination involved with interleukin-7 (IL-7) potentially enhance immune responses against tumor. In the present study, we emphasized on a herbal formulation Yi-qi-yang-yin-tian-sui-fang or TCM for short, and investigated its roles in chemotherapy in non-small cell lung cancer (NSCLC). The mice bared with tumor were treated with cisplatin (DDP) and simultaneously administrated with/without low, medium and high doses of TCMs (effective content: 0.5, 2.0 and 8.0 g/per mice) via oral gavage. The results indicated that combination of TCM further elevated the therapy efficiency of DDP in a dose-dependent manner. The growth of tumor cells was estimated by Ki-67 stain and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) assay. The addition of TCM to the DDP treatment could significantly decrease the expression of Ki-67 and promote the apoptosis of tumor cells. In addition, the serum IL-7 level was down-regulated by DDP but restored by the treatment of TCM. The expression of IL-7 and its receptor IL-7R in tumor tissues was also recovered by TCM. Furthermore, the side effect from bone marrow suppression (myelosuppression) induced by DDP were assessed. TCM could abrogate DDP-induced apoptosis of bone marrow and also remarkably induced the expressions of IL-7 and hematopoietic growth factors including G-CSF, GM-CSF, SCF, and SDF-1 in bone marrow. These data indicated that this TCM combined with DDP showed superior anti-tumor effects with reduced myelosuppression via up-regulating IL-7.
Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery
Authors: Wu Chunxian , Gao Bin , Gui Yu
Published: May 2019

Background: Postoperative cognitive dysfunction (POCD) is a great problem for anesthetized subjects and is associated with poor short- and long-term outcomes. We explored promising predictors for POCD in elderly patients after hip fracture surgery.

Methods: Elderly subjects (aged ≥65 years) undergoing surgery for hip fracture were consecutively recruited. Neuropsychological assessments were performed 1 day preoperatively (baseline) and 7 days postoperatively, and POCD was defined using the ‘Z scores’ method. Clinical data and laboratory tests were compared between patients with and without POCD development. Binary univariate and multivariate logistic regression analyses were conducted for risk factor assessment. Receiver operating characteristic (ROC) curve analysis was performed to investigate the predictive value of malondialdehyde (MDA) on postoperative day 1 (POD1) for POCD.

Results: A total of 198 patients were finally enrolled in the analysis and 51 patients exhibited POCD within 7 postoperative days, with an incidence rate of 25.8%. MDA expression on POD1 (OR: 1.12, 95%CI: 1.03–1.23, P=0.017) was the only independent risk factor for POCD according to the final multivariate logistic regression analysis. ROC curve analysis indicated that MDA on POD1 was a predictor for POCD, with an area under the curve (AUC) of 0.683 and 95%CI of 0.590–0.775 (P<0.001).

Conclusions: In conclusion, we demonstrated that MDA on POD1 was an independent risk factor for POCD in elderly subjects undergoing hip fracture surgery.
Aqueous humour concentrations of PEDF and Erythropoietin are not influenced by subthreshold micropulse laser treatment of diabetic macular edema
Authors: Midena Edoardo , Bini Silvia , Frizziero Luisa , Pilotto Elisabetta , Esposito Graziana , Micera Alessandra
Published: May 2019

Purpose: To determine if aqueous humour (AH) concentrations of Retinal Pigment Epithelium (RPE)’s biomarkers are modified after subthreshold micropulse laser (SMPL) treatment of diabetic macular edema (DME).

Methods: Naïve DME and healthy subjects were enrolled. All DME patients received SMPL treatments (577-nm yellow light, 5% duty cycle of 0.2 s, power 250 mW), according to study protocol. AH of DME eyes was sampled at baseline and periodically after first SMPL treatment. Control eyes were sampled before cataract surgery. Pigment Epithelium Derived Factor (PEDF) and Erythropoietin (EPO) were quantified with glass-chip protein array.

Results: Eighteen DME patients (central retinal thickness ≤ 400 μm on Spectral Domain Optical Coherence Tomography (SD-OCT)) and ten controls were enrolled. The main exclusion criteria were high refractive error, proliferative diabetic retinopathy, glaucoma and neurodegenerative disorders. PEDF concentration was decreased in DME patients at baseline versus controls (P=0.012), while EPO was increased (P=0.029). Both molecules’ concentrations remained stable during follow-up after treatments, compared with DME-baseline.

Conclusions: The AH concentrations of RPE biomarkers were significantly different in DME treatment-naïve eyes versus controls. The expression of PEDF and EPO remained unchanged after treatments with SMPL in DME eyes. These data are relevant for future research and applications of SMPL.
Catechol cross-linked antimicrobial peptide hydrogels prevent multidrug-resistant Acinetobacter baumannii infection in burn wounds
Authors: Khan Abidullah , Xu Miao , Wang Tengjiao , You Chuangang , Wang Xingang , Ren Haitao , Zhou Hongwei , Khan Amin , Han Chunmao , Li Peng
Published: May 2019

Hospital-acquired infections are common in burn patients and are the major contributors of morbidity and mortality. Bacterial infections such as Staphylococcus aureus (S. aureus) and Acinetobacter baumannii (A. baumannii) are difficult to treat due to their biofilm formation and rapidly acquiring resistance to antibiotics. This work presents a newly developed hydrogel that has the potential for treating bacterial wound infections. The hydrogel formulation is based on an antimicrobial peptide (AMP), epsilon-poly-l-lysine (EPL) and catechol, which was cross-linked via mussel-inspired chemistry between the amine and phenol groups. In vitro studies showed that EPL-catechol hydrogels possess impressive antimicrobial and antibiofilm properties toward multidrug-resistant A. baumannii (MRAB). In addition, cytotoxicity study with the clonal mouse myoblast cell line (C2C12) revealed the good biocompatibility of this hydrogel. Furthermore, we created a second-degree burn wound on the mice dorsal skin surface followed by contamination with MRAB. Our results showed that the hydrogel significantly reduced the bacterial burden by more than four orders of magnitude in infected burn wounds. Additionally, there was no significant histological alteration with hydrogel application on mice skin. Based on these results, we concluded that EPL-catechol hydrogel is a promising future biomaterial to fight against multidrug-resistant bacterial infections.
Wave modes excited by photosphericp-modes and mode conversion in a multi-loop system
Authors: Riedl J. M. , Van Doorsselaere T. , Santamaria I. C.
Published: May 2019

Context. Waves are ubiquitous in the solar corona and there are indications that they are excited by photosphericp-modes. However, it is unclear howp-modes in coronal loops are converted to sausage modes and transverse (kink) modes, which are observed in the corona.

Aims. We aim to investigate how those wave modes are excited in the lower corona by photospheric acoustic waves.

Methods. We built 3D magnetohydrostatic loop systems with multiple inclinations spanning from the photosphere to the lower corona. We then simulated these atmospheres with the MANCHA code, in which we perturb the equilibrium with ap-mode driver at the bottom of the domain. By splitting the velocity perturbation into components longitudinal, normal, and azimuthal to the magnetic flux surfaces we can study wave behavior.

Results. In vertical flux tubes, we find that deformed fast sausage surface waves and slow sausage body waves are excited. In inclined flux tubes fast kink surface waves, slow sausage body waves, and either a fast sausage surface wave or a plane wave are excited. In addition, we calculate a wave conversion factor (0 ≤ C ≤ 1) from acoustic to magnetic wave behavior by taking the ratio of the mean magnetic energy flux to the sum of the mean magnetic and acoustic energy flux and compare it to a commonly used theoretical conversion factor. We find that between magnetic field inclinations of 10° to 30° those two methods lie within 40%. For smaller inclinations the absolute deviation is smaller than 0.1.
The B-Star Exoplanet Abundance Study: a co-moving 16–25 MJup companion to the young binary system HIP 79098
Authors: Janson Markus , Asensio-Torres Ruben , André Damien , Bonnefoy Mickaël , Delorme Philippe , Reffert Sabine , Desidera Silvano , Langlois Maud , Chauvin Gaël , Gratton Raffaele , Bohn Alexander J. , Eriksson Simon C. , Marleau Gabriel-Dominique , Mamajek Eric E. , Vigan Arthur , Carson Joseph C.
Published: May 2019

Wide low-mass substellar companions are known to be very rare among low-mass stars, but appear to become increasingly common with increasing stellar mass. However, B-type stars, which are the most massive stars within ~150 pc of the Sun, have not yet been examined to the same extent as AFGKM-type stars in that regard. In order to address this issue, we launched the ongoing B-star Exoplanet Abundance Study (BEAST) to examine the frequency and properties of planets, brown dwarfs, and disks around B-type stars in the Scorpius-Centaurus (Sco-Cen) association; we also analyzed archival data of B-type stars in Sco-Cen. During this process, we identified a candidate substellar companion to the B9-type spectroscopic binary HIP 79098 AB, which we refer to as HIP 79098 (AB)b. The candidate had been previously reported in the literature, but was classified as a background contaminant on the basis of its peculiar colors. Here we demonstrate that the colors of HIP 79098 (AB)b are consistent with several recently discovered young and low-mass brown dwarfs, including other companions to stars in Sco-Cen. Furthermore, we show unambiguous common proper motion over a 15-yr baseline, robustly identifying HIP 79098 (AB)b as a bona fide substellar circumbinary companion at a 345 ± 6 AU projected separation to the B9-type stellar pair. With a model-dependent mass of 16–25 MJup yielding a mass ratio of <1%, HIP 79098 (AB)b joins a growing number of substellar companions with planet-like mass ratios around massive stars. Our observations underline the importance of common proper motion analysis in the identification of physical companionship, and imply that additional companions could potentially remain hidden in the archives of purely photometric surveys.
The role of stakeholders in managing polythene and plastic waste in coastal cities of Sri Lanka: a case study of the Dehiwala-Mt. lavinia municipal council region
Authors: Kariyawasam Suresh , Madhuwanthi Ayesha , Wilson Clevo
Published: May 2019

High-density urban development with mixed land uses in Sri Lankan coastal cities generate large amounts of plastic and polythene waste (PPW). The limited capacity of city councils, the deficiencies of current waste management practices and poor awareness, a significant proportion of PPW is being released into the environment, which in turn has accumulated in the marine ecosystem through canal networks. This paper analyses the current practices of PPW disposal in one such coastal region based on a sample of 579 households, 182 commercial properties, and 103 institutions. Results indicate that out of 29 tons of PPW generated in the region, around 8% was disposed into the environment in the form of landfill, burning, and discharging into water bodies. Non-parametric correlations indicate a significant correlation between reduction of PPW (waste generators), private waste collection and awareness by local media. Qualitative analysis highlights the existing limitations of current practices of PPW disposal such as non-availability of practical and cost effective alternatives (government and industries), poor awareness of PPW impacts (waste generators, media, the local council, and researchers), negative attitudes of society, law enforcement (national government and local councils) and irregular waste collection of local councils.
Rapid oil spill simulation within Ghana’s coastal waters
Authors: Adjei Sowa Derrick Martin
Published: May 2019

Given the adverse externalities of hydrocarbon operations, particularly the impacts of oil spills – environmental, political, cultural and socio-economic – the hypothetical simulations of oil spills enhances the study and appreciation of the trajectory and fate of spilled oil in the marine environment; so as to plan timely and cost effective clean-up responses and management strategies. This paper therefore presents the results of a rapid hypothetical simulation of oil spills in Ghana’s coastal waters, and the clean-up technique(s) most applicable in the area. Using MIKE 21, tidal elevations were used as forcing to run the hydrodynamic model, after which a series of hypothetical simulations were conducted with the worst case scenario divulging both the trajectories of the oil slicks and the potential areas to be impacted. The simulation results closely matched the results highlighted in the Phase-1-Development EIA report of the Jubilee Field. Following the simulation, an assessment of the most viable clean-up technique was conducted. Given the geophysical state of the coastal system and the met-ocean conditions, the mechanical recovery method, complemented by bioremediation, is most applicable due to its marginal environmental impacts.
Developing sustainable school guidelines: the case of Egypt
Authors: Harb S , ElHaggar S M , Sewilam H
Published: May 2019

Educational reform has been a concerning matter to the Egyptian government since the 20th century. In order to address the educational problems, several initiatives have instigated a quantitative expansion approach, rather than a qualitative one. Existing building assessment methods convey sustainability principles to building design. However, they do not consider the school design as an active pedagogical tool for sustainable education and development. In addition they do not integrate other imperative parameters necessary for the effective learning and development of students. The developed guideline is divided into two school rating systems; new and existing. The guideline is further divided into three main sustainability categories: energy, water, and habitat. The directing parameters of the guideline are based on sustainable building assessment parameters, Egypt’s pressing social, economic and environmental concerns, pedagogy of educational environments, students’ social, psychological, and developmental needs, in order to develop a holistic framework.
A new approach to capture heterogeneity in groundwater problem: An illustration with an Earth equation
Authors: Atangana Abdon , Alqahtani Rubayyi T.
Published: May 2019

One of the major problem faced in modeling groundwater flow problems is perhaps how to capture heterogeneity of the geological formation within which the flow takes place. In this paper, we suggested applied a newly established approach to model real world problems that combines the concept of stochastic modeling in which parameters inputs are converted into distributions and the time differential operator is replaced by non-local differential operators. We illustrated this method with the Earth equation of groundwater recharge. For each case, we provided numerical and exact solution using the newly established numerical scheme and Laplace transform. We presented some numerical simulations. The numerical graphical representations let no doubt to think that this approach is the future way of modeling complex problems.
Ambulante Versorgungsqualität für den permanenten postoperativen Hypoparathyreoidismus
Authors: Allemeyer Erik Hermann , Kossow Marielle Sophie , Riemann Burkhard , Hoffmann Matthias Wilhelm
Published: May 2019

Einleitung Der postoperative Hypoparathyreoidismus kann erhebliche akute Symptome, relevante Folgeerkrankungen und weitreichende Auswirkungen auf die Lebensqualität verursachen. Die sozioökonomische Bedeutung ist hoch. Eine individualisierte Nachsorge mit besonderer Berücksichtigung gefährdeter Patienten könnte die Versorgungsqualität verbessern. Am eigenen Patientengut unseres Schilddrüsenzentrums (Kompetenzzentrum DGAV) analysierten wir Versorgungsstrukturen und -qualität und zeigen Verbesserungspotenziale auf.

Material und Methoden Konsekutive Serie von 420 Patienten mit totaler Thyreoidektomie im Zeitraum 08/2012 bis 08/2014, Follow-Up 8–32 Monate. Gruppe I (Untersuchungskollektiv): 197 Patienten mit Calcium (Ca) im Serum (i. S.) am 1. postop. Tag < 2,1 mmol/l und/oder Parathormon (PTH) < 15 pg/ml. Gruppe II (Kontrollkollektiv): 223 Patienten mit Ca i. S. am 1. postop. Tag ≥ 2,1 mmol/l und PTH ≥ 15 pg/ml. Zielparameter bei Follow-Up: Ca- und PTH-Wert, Symptome, Lebensqualität und ambulante Versorgungsqualität durch Hausarzt (Fragebogen).

Ergebnisse Teilnahmequote bei der Follow-Up-Untersuchung 30,6 % (117/382). Häufigkeiten für Hypoparathyreoidismus: 47 % passager, 6 % permanent. Symptomzahl und empfundene Belastung bei Patienten mit Hypoparathyreoidismus nahezu identisch zum Vergleichskollektiv. Nachsorge erfolgte bei 96 % durch den Hausarzt. Kein Patient mit einem Serumcalcium ≤ 2,1 mmol/l in der Follow-Up-Untersuchung wurde nicht substituiert. Bei 33 % der substituierten Pat. mit permanentem Hypoparathyreoidismus war die Substitutionstherapie nicht ausreichend. 24 % aller 110 Patienten mit normwertigem PTH in der Follow-Up-Untersuchung erhielten eine Substitutionsmedikation trotz überwiegend (76 %) regelmäßiger Ca-Kontrollen beim Hausarzt.

Schlussfolgerung In der ambulanten hausärztlichen Versorgung von Patienten mit Hypoparathyreoidismus stellten wir sowohl Merkmale einer Über- als auch einer Unterversorgung fest. Hieraus lassen sich zur Verbesserung Zielparameter ableiten: 1. Engmaschige Nachsorge, 2. Ausreichende Substitutionstherapie für alle Patienten mit einem permanenten Hypoparathyreoidismus, 3. Zeitgerechte Beendigung der Substitutionstherapie für alle Patienten mit normwertigem Parathormon.
Acute Pulmonary Embolism: Imaging Techniques, Findings, Endovascular Treatment and Differential Diagnoses
Authors: Palm Viktoria , Rengier Fabian , Rajiah Prabhakar , Heussel Claus Peter , Partovi Sasan
Published: May 2019

Background Acute thrombotic pulmonary embolism (PE) is a common and potentially fatal event with imaging playing a pivotal role in the diagnosis and management of these patients.

Method This review discusses imaging techniques, diagnostic algorithms, imaging findings and endovascular treatment of acute thrombotic PE, and illustrates important differential diagnoses relating to the spectrum of acute non-thrombotic PE and non-embolic pulmonary artery disease. The review emphasizes information relevant for everyday radiological practice and highlights recent advances that can be readily applied in the clinical routine.

Results/Conclusion Computed tomography pulmonary angiography (CTPA) is the current reference standard for the diagnosis of acute PE. Ventilation and perfusion (VQ) scanning or – in centers with adequate expertise – magnetic resonance imaging (MRI) is indicated in pregnant or young patients and patients with contraindications to iodinated contrast. Invasive angiography is reserved for patients with intended endovascular treatment. Artifacts, acute non-thrombotic PE, chronic PE and non-embolic pulmonary artery diseases should always be considered as differential diagnoses.

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Citation Format
Experimental 177Lu-PSMA-617 radioligand therapy in a patient with extended metastasized leiomyosarcoma
Authors: Jüptner Michael , Marx Marlies , Zuhayra Maaz , Lützen Ulf
Published: May 2019

Introduction

Systemic radionuclide therapy with 177Lu-PSMA-617 is a novel treatment option in patients with metastasized and castration-resistant prostate cancer 4. The molecular target of the 177Lu-PSMA-617 radioligand therapy is the prostate-specific membrane antigen (PSMA) highly expressed on prostate cancer cells. Beyond the enhanced a﻿ccumulation of PSMA on prostate cancer cells, PSMA expression is also found on the molecular surface or in the tumor-associated neovasculature of various tumor tissues including sarcomas of the soft tissue 2. Thus, PSMA has theoretically been discussed as a possible future target for systemic radioligand therapy with 177Lu-PSMA-617 even in non-prostate malignancies 1.

Here we report on a female patient with extended metastasized leiomyosarcoma experimentally treated with one application of 177Lu-PSMA-617 radioligand therapy.
Lacrimal Diversion Devices (Sinopsys Lacrimal Stent): Sharing our Experience with Patients with Chronic Rhinosinusitis without Polyposis
Authors: Baptista Peter , Garaycochea Octavio , Prieto-Matos Carlos , Alperi Marta Alvarez de Linera , Alcalde Juan
Published: May 2019

Introduction Chronic rhinosinusitis (CRS) is a highly prevalent pathology in our society. Due to the prevalence of this condition and to the persisting symptoms despite an appropriate medical treatment, surgical techniques are often required. Lately, minimal invasive techniques have been described, such as lacrimal diversion devices (LDDs). This technique offers a fast and convenient choice for delivery of sinus irrigation and topical medication.

Objective We aimed to describe our experience with LDDs and evaluate the safety and effectiveness of the procedure in patients with moderate to severe CRS without nasal polyposis (CRSsNP) and persistent symptomatology despite medical therapy.

Methods A total of 7 patients underwent bilateral lacrimal stents placement in the operating room. A retrospective observational study was conducted. The Sino-Nasal Outcome Test-20 (SNOT-20) survey was performed and the score obtained was compared before and 1 month after the procedure.

Results The LDDs were used for an average of 80 days. During the follow-up, only three patients had a mild complication with the device (granuloma in the punctum, obstruction, and early extrusion). The mean baseline SNOT-20 score dropped significantly (p = 0.015) from 25.85 to 11.57 (mean: - 14.29) 1 month after the procedure.

Conclusion According to our experience and results, the use of LDD is a novel, feasible, and less invasive technique to treat refractory CRS. It reduces the risk of mucosal stripping, provides short-term outcomes, and the surgical procedure does not require advanced training in endoscopic sinus surgery. Moreover, it can be performed in-office under local anesthesia or sedation.
Consistent Technique Limits Suspension Laryngoscopy Complications
Authors: Larner Sean P. , Fornelli Rick A. , Griffith Shane D.
Published: May 2019

Introduction Suspension laryngoscopy (SL) is a commonly performed procedure among otolaryngologists. Several studies have shown that adverse effects occur regularly with SL.

Objective To evaluate the postoperative complications of SL, and to determine if protecting the dentition and the oral mucosa and limiting suspension times decrease the overall incidence of oral cavity and pharyngeal complications of SL.

Methods All of the cases of SL performed by 1 surgeon from November 2008 through September 2014 were retrospectively reviewed. A consistent technique for dental and mucosal protection was utilized, and suspension times were strictly limited to 30 consecutive minutes. The incidence of postoperative complications was calculated and analyzed with respect to gender, smoking status, dentition, laryngoscope type, and suspension system.

Results A total of 213 consecutive SL cases were reviewed, including 174 patients (94 male, 80 female). The overall postoperative complication rate was of 3.8%. Four patients experienced tongue-related complications, two experienced oral mucosal alterations, one had a dental injury, and one experienced a minor facial burn. The complication incidence was greater with the Zeitels system (12.5%) compared with the Lewy suspension system (3.3%), although it was not significant (p = 0.4). Likewise, the association of complications with other patient factors was not statistically significant.

Conclusion Only 8 out of 213 cases in the present series experienced complications, which is significantly less than the complication rates observed in other reports. Consistent and conscientious protection of the dentition and of the oral mucosa and limiting suspension times to 30 minutes are factors unique to our series that appear to reduce complications in endolaryngeal surgery.