bluuebunny/crossref_metadata_2025 huggingface dataset:
ON-CHART SUCCESS DYNAMICS OF POPULAR SONGS
Authors: SHIN SEUNGKYU , PARK JUYONG
Published: June 2018

In the modern era where highly-commodified cultural products compete heavily for mass consumption, finding the principles behind the complex process of how successful, “hit” products emerge remains a vital scientific goal that requires an interdisciplinary approach. Here, we present a framework for tracing the cycle of prosperity-and-decline of a product to find insights into influential and potent factors that determine its success. As a rapid, high-throughput indicator of the preference of the public, popularity charts have emerged as a useful information source for finding the market performance patterns of products over time, which we call the on-chart life trajectories that show how the products enter the chart, fare inside it, and eventually exit from it. We propose quantitative parameters to characterize a life trajectory, and analyze a large-scale data set of nearly 7,000 songs from Gaon Chart, a major weekly Korean Pop (K-Pop) chart that covers a span of six years. We find that a significant role is played by nonmusical extrinsic factors such as the established fan base of the artist and the might of production companies in the on-chart success of songs, strongly indicative of the commodified nature of modern cultural products. We also review a possible mathematical model of this phenomenon, and discuss several nontrivial yet intriguing trajectories that we call the “Late Bloomers” and the “Re-entrants” that appear to be strongly driven by serendipitous exposure on mass media and the changes of seasons.
The TUIO 2.0 Protocol
Authors: Kaltenbrunner Martin , Echtler Florian
Published: June 2018

Since its introduction in 2005, the TUIO protocol has been widely employed within a multitude of usage contexts in tangible and multi-touch interaction. While its simple and versatile design still covers the core functionality of interactive tabletop systems, the conceptual and technical developments of the past decade also led to a variety of ad-hoc extensions and modifications for specific scenarios. In this paper, we present an analysis of the strengths and shortcomings of TUIO 1.1, leading to the constitution of an extended abstraction model for tangible interactive surfaces and the specification of the second-generation TUIO 2.0 protocol, along with several example encodings of existing tangible interaction concepts.
A Lifetime of Adventures in Glycobiology
Authors: Kornfeld Stuart
Published: June 2018

My initial research experience involved studying how bacteria synthesize nucleotide sugars, the donors for the formation of cell wall polysaccharides. During this time, I became aware that mammalian cells also have a surface coat of sugars and was intrigued as to whether these sugars might be arranged in specific sequences that function as information molecules in biologic processes. Thus began a long journey that has taken me from glycan structural analysis and determination of plant lectin-binding preferences to the biosynthesis of Asn-linked oligosaccharides and the mannose 6-phosphate (Man-6-P) lysosomal enzyme targeting pathway. The Man-6-P system represents an early example of a glycan serving as an information molecule in a fundamental cellular function. The remarkable advances in the field of glycobiology since I entered have uncovered scores of additional examples of oligosaccharide–lectin interactions mediating critical biologic processes. It has been a rewarding experience to participate in the efforts that have established a central role for glycans in biology.
Nuclear Genomic Instability and Aging
Authors: Niedernhofer Laura J. , Gurkar Aditi U. , Wang Yinsheng , Vijg Jan , Hoeijmakers Jan H.J. , Robbins Paul D.
Published: June 2018

The nuclear genome decays as organisms age. Numerous studies demonstrate that the burden of several classes of DNA lesions is greater in older mammals than in young mammals. More challenging is proving this is a cause rather than a consequence of aging. The DNA damage theory of aging, which argues that genomic instability plays a causal role in aging, has recently gained momentum. Support for this theory stems partly from progeroid syndromes in which inherited defects in DNA repair increase the burden of DNA damage leading to accelerated aging of one or more organs. Additionally, growing evidence shows that DNA damage accrual triggers cellular senescence and metabolic changes that promote a decline in tissue function and increased susceptibility to age-related diseases. Here, we examine multiple lines of evidence correlating nuclear DNA damage with aging. We then consider how, mechanistically, nuclear genotoxic stress could promote aging. We conclude that the evidence, in toto, supports a role for DNA damage as a nidus of aging.
Investigation of the Thermal Improvement and the Kinetic Analysis of the Enriched Coal
Authors: Duzyol Selma , Sensogut Cem
Published: June 2018

The present research work is comprised of three main parts. The first part is about the enrichment of lignite coal by the utilization of dense medium separation called float and sink method. The second part deals with the investigation of the thermal behaviour for the coals enriched while the last part is concerned with the kinetic analysis of the coal combustion. The float and sink method is the mostly used technique for low-rank coal beneficiation in coal preparation plants of Turkey. In order to realize this process, the coal samples were, at first, fractioned to five different sizes which were -32+25 mm, -25+16 mm, -16+8 mm, -8+4.75 mm, and -4.75+2 mm. Each fraction was, then, processed in the dense mediums with the specific gravities of 1.20, 1.30, 1.40, 1.50, and 1.60 g/cm3, respectively. The thermal behaviour of the floated materials from the float and sink process was investigated in detail with the thermogravimetric analysis (TG) and the differential thermogravimetric analysis (DTG). The ignition and peak temperatures for the samples were also ascertained and correlated with the float and sink test results. In the final part of the study, the kinetic analysis of the coal samples was carried out by the Coats–Redfern method and the activation energies of the enriched coals were determined. The activation energies of the raw and the enriched coals were assessed and compared. The calculated activation energy values for the combustion reactions of the coal samples ranged were found to be between 15.17 kJ/mol and 97.45 kJ/mol. The strong correlation was obtained between the float and sink test results especially with the ash content of the coal samples and the combustible characteristic of the floated materials such as ignition temperatures, peak temperatures, and activation energies. The combustion characteristics of the coal samples were resultantly ascertained to be very dependent on the coal structure.
Acquired Factor VIII Inhibitor Presenting as Occult GI Bleeding
Authors: Pacheco Cano Carlos I. , Arosemena Marilyn A. , Iordanov Roumen B. , Lingamaneni Ankitha , Aneja Ankur
Published: June 2018

An acquired coagulation factor deficiency is characterized by acquired autoantibodies against specific clotting factors in those without diagnosed hemophilia. It is a relatively rare condition with an incidence of approximately one case per million per year. We present a case report of an elderly male who initially presented with an occult GI bleed that was identified with a positive fecal occult blood test result. This is the first case reported to our knowledge of an acquired factor inhibitor deficiency presenting in this manner. We postulate the importance of acquired factor inhibitors in the setting of unexplained anemia given absence of overt clinical symptoms that could contribute to aggravate an established GI bleed, especially in the elderly population.
Opportunistic NOMA‐Based Massive MIMO Precoding for 5G New Radio
Authors: Xiao Ke , Kadoch Michel , Rutagemwa Humphrey , Li Chen
Published: June 2018

This work investigates multicast services, which play a critical role in 5G new radio (NR). In particular, we propose a hybrid unicast/multicast MIMO precoding based on NOMA. Our scheme first categorizes unicast users into NOMA and non‐NOMA types and then utilizes null space and successive interference cancellation to eliminate the signal leakage. To justify the effectiveness and efficiency of our design, we also present simulation results in typical massive MIMO scenarios.
Characterization of Seminiferous Epithelium Stages in the Wild Javan Muntjac (Muntiacus muntjak muntjak) Using the Tubular Morphology Method
Authors: Wahyuni Sri , Gholib Gholib , Adnyane I Ketut Mudite , Agil Muhammad , Hamny Hamny , Agungpriyono Srihadi , Yusuf Tuty Laswardi
Published: June 2018

Stages of the seminiferous epithelium of the testis of the wild Javan muntjac (Muntiacus muntjak muntjak) in hard antler period were characterized based on the tubular morphology method. The number and the relative frequencies of seminiferous epithelium stages and the morphometry of germinal cell nuclei were identified microscopically. We identified eight stages of seminiferous epithelium in testicular tissue of the Javan muntjac and found that the relative frequencies of stages I to VIII were 14.87, 15.12, 17.75, 6.87, 7.37, 12.37, 13, and 12.62%, respectively. The diameter of the nuclei of germinal cells varied in each stage of seminiferous epithelium. Diplotene-stage primary spermatocytes had prominent and large nuclei ~8.97 ± 1.0μm in stages III and IV. Pachytene primary spermatocytes appeared in most stages, except stage IV, whereas leptotene- and diplotene-stage primary spermatocytes were found in stages I and II, and III and IV, respectively. Round spermatids were observed in stages IV to VIII and in stage I but were absent in stages II and III, while elongated spermatids were observed in all stages except stage I. Our findings show that the stages of seminiferous epithelium in the Javan muntjac are similar to those found in neotropical cervids, small ruminants, and other domestic animals.
Assessment of Disability and Factors Determining Disability among Inhabitants of South-Eastern Poland Aged 71–80 Years
Authors: Ćwirlej-Sozańska Agnieszka , Sozański Bernard , Wiśniowska-Szurlej Agnieszka , Wilmowska-Pietruszyńska Anna , Kujawa Jolanta
Published: June 2018

Introduction. The aim of the study was to assess the level of disability in a sample of older people in south-eastern Poland and to identify any potential relationship between their profile of functioning and a complex set of variables including activities, participation, and contextual factors.Materials and Methods. The study included 800 people aged 71–80 years. The WHODAS 2.0 questionnaire was applied for the assessment of disability.Results. A total of 43.88% of the interviewees showed a moderate level of disability, while 17.75% had severe or extremely high levels of disability. In addition, 7.75% of the interviewees had no functional limitations and 30.62% demonstrated a mild level of disability. The studied individuals reported the greatest difficulties with life activities such as cleaning, cooking, or shopping, followed by Limited Participation and then getting along. Age, number of chronic diseases, a low level of education, a low level of physical activity, poor living conditions, and lack of opportunities for daily help significantly contributed to higher levels of disability.Conclusions. Measures intended to reduce the level of disability in older adults should focus on improving medical care, health education, increasing physical activity, adapting housing to the needs of everyday functioning, and providing daily help.
The Use of Insecticide-Treated Curtains for Control ofAedes aegyptiand Dengue Virus Transmission in “Fraccionamiento” Style Houses in México
Authors: Loroño-Pino Maria A. , Uitz-Mena Ana , Carrillo-Solís Claudia M. , Zapata-Gil Rocío J. , Camas-Tec Dora M. , Talavera-Aguilar Lourdes G. , Cetina-Trejo Rosa C. , Flores-Flores Luis F. , Puc-Tinal María C. , Caamal-Jiménez Clara , Reyes-Solís Guadalupe , García-Rejón Julián E. , Saavedra-Rodriguez Karla , Eisen Lars , Keefe Thomas J. , Black IV William C. , Beaty Barry J.
Published: June 2018

Dengue, chikungunya, yellow fever, and Zika viruses transmitted byAedes aegyptimosquitoes are major public health threats in the tropical and subtropical world. In México, construction of large tracts of “fraccionamientos” high density housing to accommodate population growth and urbanization has provided fertile ground forAe. aegypti-transmitted viruses. We investigated the utility of pyrethroid-treated window curtains to reduce both the abundance ofAe. aegyptiand to prevent dengue virus (DENV) transmission in fraccionamiento housing. Windows and doors of fraccionamiento homes in urban/suburban areas, whereAe. aegyptipyrethroid resistance associated with the Ile1016 knock down resistance (kdr) mutation in the voltage gated sodium channel gene was high, and in rural areas, where kdr resistance was low, were fitted with either insecticide-treated curtains (ITCs) or non-treated curtains (NTCs). The homes were monitored for mosquito abundance and DENV infection. ITCs reduced the indoor abundance ofAe. aegyptiand the number of DENV-infected mosquitoes in homes in rural but not in urban/suburban study sites.The presence of non-treated screens also was associated with reduced numbers of mosquitoes in homes. “Super-infested” homes, yielding more than 50 mosquitoes, including DENV-infected mosquitoes, provide a significant public health risk to occupants, visitors, and people in neighboring homes.
Construction Low Complexity and Low Delay CDS for Big Data Code Dissemination
Authors: Liu Xiao , Dong Mianxiong , Liu Yuxin , Liu Anfeng , Xiong Neal N.
Published: June 2018

The diffusion of codes is an important processing technology for big data networks. In previous scheme, data analysis was conducted for small samples of big data and complex problems that cannot be processed by big data technology. Due to the limited capacity of intelligence device, a better method is to select a set of nodes (intelligence device) to form a connected dominating set (CDS) to save energy, and constructing CDS is proved to be a complete NP problem. However, it is a challenge to reduce the communication delay and complexity for urgent data transmission in big data. In this paper, an appropriate duty cycle control (ADCC) scheme is proposed to reduce communication delay and complexity while improving energy efficient in CDS‐based WSNs. In ADCC scheme, the method for constructing CDS is proposed at lower complexity. Nodes in CDS are selected according to the degree of nodes. Then, duty cycle of dominator nodes in CDS is higher than that of dominated nodes, so the communication delay in the proposed scheme is far less than that of previous scheme. The duty cycle of dominated nodes is small to save energy. This is because the number of dominator nodes in CDS is far less than the number of dominated nodes whose duty cycle is small; thus, the total energy consumption of the network is less than that of the previous scheme. As a result, the performance of energy consumption and communication delay and complex have been improved. Its complexity is reduced a lot for big data. The theoretical analysis shows that compared to the previous scheme, the transmission delay can be reduced 25–92% and the energy efficiency is improved by about 80% while retaining network lifetime.
Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
Authors: Wang Zheng , Li Wenting , Guo Qiongya , Wang Yuming , Ma Lijun , Zhang Xiaoju
Published: June 2018

Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.
Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues
Authors: Li Weiyang , Qi Yanwei , Cui Xiaofang , Huo Qing , Zhu Liangxi , Zhang Aiping , Tan Meihua , Hong Qilan , Yang Yan , Zhang Huali , Liu Chuanxin , Kong Qingsheng , Geng Jiazheng , Tian Yanjun , Kong Fancong , Man Dongmei
Published: June 2018

High-risk HPV is clearly associated with cervical cancer. HPV integration has been confirmed to promote carcinogenesis in the previous studies. In our study, a total of 285 DNA breakpoints and 287 RNA breakpoints were collected. We analyzed the characteristic of HPV integration in the DNA and RNA samples. The results revealed that the patterns of HPV integration in RNA and DNA samples differ significantly. FHIT, KLF5, and LINC00392 were the hotspot genes integrated by HPV in the DNA samples. RAD51B, CASC8, CASC21, ERBB2, TP63, TEX41, RAP2B, and MYC were the hotspot genes integrated by HPV in RNA samples. Breakpoints of DNA samples were significantly prone to the region of INTRON (P < 0.01, Chi-squared test), whereas in the RNA samples, the breakpoints were prone to EXON. Pathway analysis had revealed that the breakpoints of RNA samples were enriched in the pathways of transcriptional misregulation in cancer, cancer pathway, and pathway of adherens junction. Breakpoints of DNA samples were enriched in the pathway of cholinergic synapse. In summary, our data helped to gain insights into the HPV integration sites in DNA and RNA samples of cervical cancer. It had provided theoretical basis for understanding the mechanism of tumorigenesis from the perspective of HPV integration in the HPV-associated cervical cancers.
Chemical Composition of Corrosion Products of Rebar Caused by Carbonation and Chloride
Authors: Geng Jundi , Liu Junzhe , Yan Jiali , Ba Mingfang , He Zhimin , Li Yushun
Published: June 2018

The microstructures of steel bars were studied by X-ray photoelectron spectroscopy (XPS), and the mechanism of corrosion of steel bars under the corrosion factors was elucidated. The results show that the passivation film and corrosive surface of the steel surface in the solution of the chloride-containing salt were coarser and the surface state was denser. The main corrosion products are FeOOH and FeO. The surface of the steel immersed in the simulated carbonized solution had loose pores. The main components are FeOOH, Fe3O4, and Fe2O3. The surface of the steel bar has a large amount of yellowish brown corrosion products in the simulated carbonization and chloride salt. The surface of the corrosion products was stripped and the main components are FeOOH, Fe3O4, and FeCl3, where the content of FeOOH is as high as 60%. The peak value of iron is gradually increased from the simulated chloride salt solution to the carbonized solution to the combined effect of carbonation and chloride salt; the iron oxide content is increased and corrosion of steel is obviously serious.
Presurgical Identification of Uterine Smooth Muscle Malignancies through the Characteristic FDG Uptake Pattern on PET Scans
Authors: Ho Kung-Chu , Dean Fang Yu-Hua , Lin Gigin , Ueng Shir-Hwa , Wu Tzu-I , Lai Chyong-Huey , Chueh Ho-Yen , Chao Angel , Chang Ting-Chang , Yen Tzu-Chen
Published: June 2018

The unidentified presence of uterine smooth muscle malignancies poses a tremendous risk in women planning surgery for presumed benign leiomyomas. We sought to investigate whether preoperative FDG PET may be useful to identify leiomyosarcomas (LMS) and smooth muscle tumors of uncertain malignant potential (STUMP). Methods. We investigated patients with rapidly growing uterine masses which were suspected of being malignant on ultrasound or MRI. Among the 21 patients who underwent FDG PET, we identified 7 LMS, 1 STUMP, and 13 leiomyomas. PET-derived parameters and FDG uptake patterns were analyzed retrospectively. Results. The SUVmax values of LMS/STUMP (range: 3.7–11.8) were significantly higher than those observed in leiomyomas (range: 2.0–9.4; P=0.003) despite a significant overlap. The metabolic tumor/necrosis ratio was significantly higher in LMS/STUMP than in leiomyomas (P<0.001), with no significant intergroup overlaps. All LMS/STUMP revealed a characteristic pattern of FDG uptake, identifying a specific “hollow ball” sign (corresponding to areas of coagulative tumor necrosis). In contrast, this sign was invariably absent in patients with leiomyomas. Conclusion. The characteristic FDG uptake pattern instead of SUV on PET images allows identifying LMS/STUMP in patients with rapidly growing uterine masses, avoiding the deleterious consequences of regular surgery for presumed benign leiomyomas.
Photoinduced Synthesis of Hierarchical Flower-Like Ag/Bi2WO6 Microspheres as an Efficient Visible Light Photocatalyst
Authors: Wu Shuisheng , Tan Nianyuan , Lan Donghui , Yi Bing
Published: June 2018

A series of three-dimensional microflower-like Ag/Bi2WO6 composites were synthesized through a simple and practical photoreduction process with different photoreduction times. The UV-visible diffuse reflectance spectra indicate that the spectrum of Ag/Bi2WO6 is significantly red-shifted compared to pure Bi2WO6 microspheres in the visible light region. The photocatalytic activities of the as-prepared samples were evaluated by the decolorization of rhodamine B under visible light irradiation. The photocatalytic reaction rate constants of the Ag/Bi2WO6 with a photoreduction time of 20 min was 3.60 times bigger than those of pure Bi2WO6. The enhanced photocatalytic activity could be attributed to the synergistic effect of increased light absorption range and the effective separation of photogenerated carriers caused by Ag nanoparticles.
An Improved Nondominated Sorting Genetic Algorithm III Method for Solving Multiobjective Weapon-Target Assignment Part I: The Value of Fighter Combat
Authors: Li You , Kou Yingxin , Li Zhanwu
Published: June 2018

Multiobjective weapon-target assignment is a type of NP-complete problem, and the reasonable assignment of weapons is beneficial to attack and defense. In order to simulate a real battlefield environment, we introduce a new objective—the value of fighter combat on the basis of the original two-objective model. The new three-objective model includes maximizing the expected damage of the enemy, minimizing the cost of missiles, and maximizing the value of fighter combat. To solve the problem with complex constraints, an improved nondominated sorting algorithm III is proposed in this paper. In the proposed algorithm, a series of reference points with good performances in convergence and distribution are continuously generated according to the current population to guide the evolution; otherwise, useless reference points are eliminated. Moreover, an online operator selection mechanism is incorporated into the NSGA-III framework to autonomously select the most suitable operator while solving the problem. Finally, the proposed algorithm is applied to a typical instance and compared with other algorithms to verify its feasibility and effectiveness. Simulation results show that the proposed algorithm is successfully applied to the multiobjective weapon-target assignment problem, which effectively improves the performance of the traditional NSGA-III and can produce better solutions than the two multiobjective optimization algorithms NSGA-II and MPACO.
Preparation and Characterization of Antioxidant Peptides from Carrot Seed Protein
Authors: Ye Nanhui , Hu Pei , Xu Shuli , Chen Minming , Wang Shaoyun , Hong Jing , Chen Taotao , Cai Tiantian
Published: June 2018

Carrot is a very popular vegetable and used for culinary and cosmetic purposes. Carrot seeds can be used for treatment of hangovers and stimulating menstruation. In the present study, the carrot seed protein (CSP) extracted from carrot seed (Daucus carota L.) was hydrolysed by four proteases (papain, trypsin, neutrase, and alcalase). Alcalase hydrolysate exhibited the strongest DPPH radical-scavenging activity (DRSA). The optimum hydrolysis condition for the antioxidant peptide production from CSP was obtained using response surface methodology (RSM). The optimum condition was as follows: hydrolysis time of 3.50 h, substrate concentration of 52.8 g/L, and protease dosage of 419.36 U/g, under which DRSA of 82.46% at 2 mg/mL was obtained. The carrot seed protein hydrolysates (CSPHs) were separated using size exclusion chromatography in order to obtain peptides with stronger antioxidant activity. The hydrolysates were fractionated into four peaks, and fractions F3 and F4 with smaller molecular weight showed stronger antioxidant activity. These findings indicated that the success of RSM in optimizing the hydrolysis conditions and the further work in separation of antioxidant peptides in CSPH is feasible. The CSPH exhibites good antioxidant properties and can be used as useful ingredient in foods.
Multisource Data Framework for Road Traffic State Estimation
Authors: Salanova Grau Josep Maria , Mitsakis Evangelos , Tzenos Panagiotis , Stamos Iraklis , Selmi Luigi , Aifadopoulou Georgia
Published: June 2018

This paper presents a framework for data collection, filtering, and fusion, together with a set of operational tools to validate, analyze, utilize, and highlight the added value of probe data. Data is collected by both conventional (loops, radars, and cameras) and innovative (Floating Car Data, detectors of Bluetooth devices) technologies and refers to travel times and traffic flows on road networks. The city of Thessaloniki, Greece, serves as a case study for the implementation of the proposed framework. The methodology includes the estimation of traffic flow based on measured travel time along predefined routes and short-term forecasting of traffic volumes and their spatial expansion in the road network. The proposed processes and the framework itself have the potential of being implemented in urban road networks.
Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations
Authors: Sowalsky Adam G. , Ye Huihui , Bhasin Manoj , Van Allen Eliezer M. , Loda Massimo , Lis Rosina T. , Montaser-Kouhsari Laleh , Calagua Carla , Ma Fen , Russo Joshua W. , Schaefer Rachel J. , Voznesensky Olga S. , Zhang Zhenwei , Bubley Glenn J. , Montgomery Bruce , Mostaghel Elahe A. , Nelson Peter S. , Taplin Mary-Ellen , Balk Steven P.
Published: June 2018

Primary prostate cancer can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant prostate cancer (mCRPC) remains unclear. In this study, we microdissected residual prostate cancer foci in radical prostatectomies from 18 men treated with neoadjuvant-intensive androgen deprivation therapy (leuprolide, abiraterone acetate, and prednisone) and analyzed them for resistance mechanisms. Transcriptome profiling showed reduced but persistent androgen receptor (AR) activity in residual tumors, with no increase in neuroendocrine differentiation. Proliferation correlated negatively with AR activity but positively with decreased RB1 expression, and whole-exome sequencing (WES) further showed enrichment for RB1 genomic loss. In 15 cases where 2 or 3 tumor foci were microdissected, WES confirmed a common clonal origin but identified multiple oncogenic alterations unique to each focus. These findings show that subclones with oncogenic alterations found in mCRPC are present in primary prostate cancer and are selected for by neoadjuvant-intense androgen deprivation therapy. In particular, this study indicates that subclonal RB1 loss may be more common than previously appreciated in intermediate- to high-risk primary prostate cancer and may be an early event, independent of neuroendocrine differentiation, in the development of mCRPC. Comprehensive molecular analyses of primary prostate cancer may detect aggressive subclones and possibly inform adjuvant strategies to prevent recurrence.

Significance: Neoadjuvant androgen deprivation therapy for prostate cancer selects for tumor foci with subclonal genomic alterations, which may comprise the origin of metastatic castration-resistant prostate cancer. Cancer Res; 78(16); 4716–30. ©2018 AACR.
Chemotherapy Sensitizes Therapy-Resistant Cells to Mild Hyperthermia by Suppressing Heat Shock Protein 27 Expression in Triple-Negative Breast Cancer
Authors: Mu Chaofeng , Wu Xiaoyan , Zhou Xinyu , Wolfram Joy , Shen Jianliang , Zhang Dechen , Mai Junhua , Xia Xiaojun , Holder Ashley M. , Ferrari Mauro , Liu Xuewu , Shen Haifa
Published: June 2018

Purpose: Triple-negative breast cancer (TNBC) is a clinically aggressive disease with poor prognosis. Conventional chemotherapeutics are generally able to shrink the tumor mass, but often fail to completely eradicate cancer stem–like cells (CSCs) that are responsible for high risk of relapse and frequent metastases. In this study, we examined thermal sensibility of CSCs, developed an approach that enabled concurrent elimination of both the bulk of cancer cells and CSCs, and investigated the underlying mechanism.

Experimental Design: We designed a platform consisting of gold nanoparticle-coated porous silicon microparticle (AuPSM) that was also loaded with docetaxel micelles (mDTXs) to enable concurrent killing of the bulk of cancer cells by released mDTX and CSCs by mild hyperthermia upon stimulation of AuPSM with near infrared. In addition, we examined the role of heat shock proteins in sensitizing CSC killing. Finally, we applied mDTX-loaded AuPSM to treat mice with SUM159 and 4T1 orthotopic tumors and evaluated tumor growth and tumor metastasis.

Results: MDA-MB-231 and SUM159 TNBC cells treated with mDTX-loaded AuPSM and mild hyperthermia displayed significantly reduced efficiencies in mammosphere formation than those treated with mDTX alone or mild hyperthermia alone. Combination treatment also completely inhibited SUM159 orthotopic tumor growth and 4T1 tumor metastasis. Mechanistically, DTX treatment suppressed expression of heat shock protein 27 in cancer cells including the CSCs, rendering cells sensitive to mild hyperthermia.

Conclusions: Our results indicate that chemotherapy sensitizes CSC to mild hyperthermia. We have developed an effective therapeutic approach to eliminate therapy-resistant cells in TNBC. Clin Cancer Res; 24(19); 4900–12. ©2018 AACR.
Integrating Radiosensitivity and Immune Gene Signatures for Predicting Benefit of Radiotherapy in Breast Cancer
Authors: Cui Yi , Li Bailiang , Pollom Erqi L. , Horst Kathleen C. , Li Ruijiang
Published: June 2018

Purpose: Breast cancer is a heterogeneous disease and not all patients respond equally to adjuvant radiotherapy. Predictive biomarkers are needed to select patients who will benefit from the treatment and spare others the toxicity and burden of radiation.

Experimental Design: We first trained and tested an intrinsic radiosensitivity gene signature to predict local recurrence after radiotherapy in three cohorts of 948 patients. Next, we developed an antigen processing and presentation-based immune signature by maximizing the treatment interaction effect in 129 patients. To test their predictive value, we matched patients treated with or without radiotherapy in an independent validation cohort for clinicopathologic factors including age, ER status, HER2 status, stage, hormone-therapy, chemotherapy, and surgery. Disease-specific survival (DSS) was the primary endpoint.

Results: Our validation cohort consisted of 1,439 patients. After matching and stratification by the radiosensitivity signature, patients who received radiotherapy had better DSS than patients who did not in the radiation-sensitive group [hazard ratio (HR), 0.68; P = 0.059; n = 322], whereas a reverse trend was observed in the radiation-resistant group (HR, 1.53; P = 0.059; n = 202). Similarly, patients treated with radiotherapy had significantly better DSS in the immune-effective group (HR, 0.46; P = 0.0076; n = 180), with no difference in DSS in the immune-defective group (HR, 1.27; P = 0.16; n = 348). Both signatures were predictive of radiotherapy benefit (Pinteraction = 0.007 and 0.005). Integration of radiosensitivity and immune signatures further stratified patients into three groups with differential outcomes for those treated with or without radiotherapy (Pinteraction = 0.003).

Conclusions: The proposed signatures have the potential to select patients who are most likely to benefit from radiotherapy. Clin Cancer Res; 24(19); 4754–62. ©2018 AACR.
KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer
Authors: Wang Wenyu , Lim Keng Gat , Feng Min , Bao Yi , Lee Puay Leng , Cai Yu , Chen Yufeng , Zhang Hao , Marzese Diego , Hoon Dave S.B. , Yu Qiang
Published: June 2018

Despite showing promise against PIK3CA-mutant breast cancers in preclinical studies, PI3K/AKT pathway inhibitors demonstrate limited clinical efficacy as monotherapy. Here, we found that histone H3K27me3 demethylase KDM6B-targeted IGFBP5 expression provides a protective mechanism for PI3K/AKT inhibitor-induced apoptosis in breast cancer cells. We found that overexpression of KDM6B and IGFBP5 in luminal breast cancer are positively associated with poorer disease outcomes. Mechanistically, KDM6B promotes IGFBP5 expression by antagonizing EZH2-mediated repression, and pharmacologic inhibition of KDM6B augments apoptotic response to PI3K/AKT inhibitor treatment. Moreover, the IGFBP5 expression is upregulated upon acquired resistance to the PI3K inhibitor GDC-0941, which is associated with an epigenetic switch from H3K27me3 to H3K27Ac at the IGFBP5 gene promoter. Intriguingly, GDC-0941–resistant breast cancer cells remained sensitive to KDM6B or IGFBP5 inhibition, indicating the dependency on the KDM6B–IGFBP5 axis to confer the survival advantage in GDC-0941–resistant cells. Our study reveals an epigenetic mechanism associated with resistance to targeted therapy and demonstrates that therapeutic targeting of KDM6B-mediated IGFBP5 expression may provide a useful approach to mitigate both intrinsic and acquired resistance to the PI3K inhibitor in breast cancer. Mol Cancer Ther; 17(9); 1973–83. ©2018 AACR.
Age-Related Dry Eye Lactoferrin and Lactobionic Acid
Authors: Rusciano Dario , Pezzino Salvatore , Olivieri Melania , Cristaldi Martina , Gagliano Caterina , Lupo Gabriella , Anfuso Carmelina Daniela
Published: June 2018

Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex (being more frequent among women) and age (increasing with aging). Therefore, specific treatments taking into account the etiology of the disease would be desired. The role of lactoferrin and its functional mimetic lactobionic acid are reported here as a possible remedy for age-related dry eye.
Association of Thromboembolic Risk Score with Left Atrial Thrombus and Spontaneous Echocardiographic Contrast in Non-Anticoagulated Nonvalvular Atrial Fibrillation Patients
Authors: Huang Jun , Liao Hong-tao , Fei Hong-wen , Xue Yu-mei , Zhang Li , Lin Qiong-wen , Ren Si-qi , Zhan Xian-zhang , Fang Xian-hong , Zheng Mu-rui , Wu Shu-lin , Xu Lin
Published: June 2018

Objectives: The aim of the study was to examine the association of CHADS2/CHA2DS2-VASc scores with left atrial thrombus (LAT) and spontaneous echocardiographic contrast (SEC) in non-anticoagulated nonvalvular atrial fibrillation (NVAF) spontaneous patients, and to develop a new scoring system for LAT/SEC prediction. Methods: Consecutive non-anticoagulated NVAF patients with or without LAT/SEC by transesophageal echocardiography were identified in the Guangdong General Hospital. Results: Among 2,173 patients, the prevalence of LAT/SEC was 4.9%. Both predictive values of CHADS2 and CHA2DS2-VASc scores for the presence of LAT/SEC were low-to-moderate (receiver operating characteristic [ROC] = 0.591 and 0.608, respectively, p = 0.90). By multivariate analysis, non-paroxysmal AF, decreased left ventricular ejection fraction, and left atrial enlargement were positively associated with LAT/SEC, while CHADS2/CHA2DS2VASc scores were not. A new scoring system based on these 3 factors above significantly improved the discrimination for LAT/SEC (ROC = 0.792). Conclusions: CHADS2/CHA2DS2-VASc scores had limited value in predicting LAT/SEC; a new scoring system that combines AF type and echocardiographic parameters may better predict LAT/SEC as a surrogate for cardioembolic risk in NVAF patients.
МІСЦЕ МЕДИЧНОЇ СЕСТРИ У ЗАБЕЗПЕЧЕННІ БЕЗПЕКИ ПАЦІЄНТІВ ТА МЕДИЧНОГО ПЕРСОНАЛУ ПРИ ВПРОВАДЖЕННІ ТА ВИКОРИСТАННІ НОВИХ ТЕХНОЛОГІЙ МЕДИЧНОЇ ГАЛУЗІ
Authors: Volynets K. V. , Havryryuk M. Ye.
Published: June 2018

У статті висвітлено роль медичних сестер у забезпеченні інфекційної безпеки при впровадженні нових методик лікування.
Storytelling Is Intrinsically Mentalistic: A Functional Magnetic Resonance Imaging Study of Narrative Production across Modalities
Authors: Yuan Ye , Major-Girardin Judy , Brown Steven
Published: June 2018

People utilize multiple expressive modalities for communicating narrative ideas about past events. The three major ones are speech, pantomime, and drawing. The current study used functional magnetic resonance imaging to identify common brain areas that mediate narrative communication across these three sensorimotor mechanisms. In the scanner, participants were presented with short narrative prompts akin to newspaper headlines (e.g., “Surgeon finds scissors inside of patient”). The task was to generate a representation of the event, either by describing it verbally through speech, by pantomiming it gesturally, or by drawing it on a tablet. In a control condition designed to remove sensorimotor activations, participants described the spatial properties of individual objects (e.g., “binoculars”). Each of the three modality-specific subtractions produced similar results, with activations in key components of the mentalizing network, including the TPJ, posterior STS, and posterior cingulate cortex. Conjunction analysis revealed that these areas constitute a cross-modal “narrative hub” that transcends the three modalities of communication. The involvement of these areas in narrative production suggests that people adopt an intrinsically mentalistic and character-oriented perspective when engaging in storytelling, whether using speech, pantomime, or drawing.
Overlapping Boundaries in the City: Mahalle and Kahal in the Early Modern Ottoman Urban Context
Authors: Karagedikli Gürer
Published: June 2018

In the present article, I examine the construction and articulation of urban and communal identities in the early modern Ottoman Empire with special reference to the complex and dynamic local Jewish identities in Edirne. I analyse the terminology used for identifying Jewish litigants at the Islamic court in Edirne based on 12 cases selected from the Islamic court registers. In other words, I scrutinize in which cases the court identified Jews by their membership of a particular congregation (Heb.kahal; pl.kehalim), in which cases by their residential affiliations (Ott.mahalle; pl.mahallat, “urban quarter”), and in which by a combination of these aforementioned ascriptions. In so doing, I attempt to enhance our understanding about pre-modern people who were simultaneously members of multiple religious, spatial, ethnic or occupational sub-communities. More specifically, I examine which of the Jews’ multiple identities (i.e.,kahalas religious/ethnic;mahalleas spatial) were emphasized by the judges of the Muslim courts. I suggest that various identification markers were employed by court personnel to define the Edirne Jews. While in some matters the fiscally, administratively, as well as socially defined spatial identity based on the termmahallewas employed, in other cases the ethnic/communal identity based on the Jewishkahal—that was also a taxable unit—was the prevalent concept.
Legitimacy and Civic Culture: Trust in Democracy in the Czech Republic after EU Accession (2004-2014)
Authors: Sedláčková Markéta , Šafr Jiří
Published: June 2018

This paper investigates the role of civic culture and other political factors in support for democracy in the Czech Republic during the decade followingEUaccession. The goal is to assess the validity of civic virtue theory and to compare the impact of these factors on affective legitimacy using theISSPCitizenship modules 2004 and 2014. The authors’ findings show rather weak but stable effects of the horizontal dimension of civic culture – social trust (but not membership in civic organizations), while the influence of the vertical dimension (trust in institutions, political interest, voting) is more variable, influenced by political turbulences. The time comparison also provides evidence of influence of right-wing political ideology and strong and stable effects of evaluations of political and economic performance.
The Emergence of Trust: Social Figuration in Supply Networks
Authors: Akkermans Henk
Published: June 2018

Trust is an essential governance mechanism in present-day supply networks, where many independent parties have to coordinate their activities. It is often assumed that trustful behavior at least partly depends on the inner dispositions of actors. Other theories suggest that this behavior is an emergent property of the supply network, generated by the interactions between the actors in the network. Half a century ago, the social figuration theory of Norbert Elias was the first formulation of such a theory. This research tests this emergent property theory in a series of simulation-based thought experiments. A generic agent-based model of buyer-supplier interactions in a build-to-forecast supply chain is used as a dynamic hypothesis to test this theory. The inner dispositions of the actors towards trust and opportunistic behavior can be changed here. Current trust levels are influenced by these inner dispositions, but are also changed by the perceived behavior of the other party. Trust levels of the actors also determine their behavior. In the simulation this creates vicious or virtuous cycles of mutual trust and performance, so called relationship spirals. Model analysis shows that beyond a certain level of external volatility, the development of trust on both sides no longer bears any direct relation to the inner dispositions of the network parties. This confirms the dynamic hypothesis. It also again establishes the strength of Elias’s original social figuration theory.
Child Participation in the Swedish Child Protection System
Authors: Leviner Pernilla
Published: June 2018

This article deals with children’s right to participation through legal representatives in the Swedish child protection system, with a specific focus on if and how children are given the possibility to influence decisions made about them in this context. An overall question is whether the regulation is clear as to what should be achieved when it comes to participation for children and what weight children’s wishes and views should be given. Based on a critical legal analysis it is shown that the Swedish system, although having a clear ‘child-friendly image’, is problematic in both these aspects. At present, child participation in the Swedish system is emphasised in theory and in goal-oriented statutes, while at the same time, children to a large extent are ‘legally protected’ from involvement, not the least from influencing decisions made. It is suggested that, for the Swedish child protection system to truly meet its “child-friendly” image and honestly look into how to become more child-inclusive, there is a need to re-think how to best achieve participation for children and also clarify what participation is intended to mean in practice.
A new species and a new record of Pelthydrus Orchymont, 1919 from Yunnan, China (Coleoptera: Hydrophilidae: Hydrophilinae)
Authors: ZHU BINGYUE , JI LANZHU , BIAN DONGJU
Published: June 2018

The members of the genus Pelthydrus are small-sized aquatic beetles which belong to the water scavenger beetle family Hydrophilidae. At present the lineage includes 63 valid species mainly occurring in Asia, with 21 known from China (Bian et al. 2008, 2009; Hansen 1999; Schönmann 1995). One new species is described here, which belongs to the Pelthydrus sculpturatus species group, bringing the total number of species within the group to seven (Schönmann 1995). One additional species is reported from China for the first time. Specimens were collected from Yunnan Province and are deposited in IAECAS (Institute of Applied Ecology, Shenyang, Chinese Academy of Sciences).
Taxonomic revision of the Square-tailed Drongo species complex (Passeriformes: Dicruridae) with description of a new species from western Africa
Authors: FUCHS JÉRÔME , DOUNO MORY , BOWIE RAURI C.K. , FJELDSÅ JON
Published: June 2018

We describe a new species of drongo in the Square-tailed Drongo (Dicrurus ludwigii) complex using a combination of biometric and genetic data. The new species differs from previously described taxa in the Square-tailed Drongo complex by possessing a significantly heavier bill and via substantial genetic divergence (6.7%) from its sister-species D. sharpei. The new species is distributed across the gallery forests of coastal Guinea, extending to the Niger and Benue Rivers of Nigeria. We suspect that this taxon was overlooked by previous avian systematists because they either lacked comparative material from western Africa or because the key diagnostic morphological character (bill characteristics) was not measured. We provide an updated taxonomy of the Square-tailed Drongo species complex.
Notes on the genus Conocephalus Thunberg, 1815 (Orthoptera: Tettigoniidae: Conocephalinae) in Southwest China with description of one new species
Authors: LI YANQING , SHI FUMING
Published: June 2018

This paper reports eight species of the genus Conocephalus from Southwest China, including one new species, Conocephalus (Anisoptera) gracilicercus sp. nov., and provides the characteristic and habitus photographs.