bluuebunny/crossref_metadata_2025 huggingface dataset:
The e-Psychonauts’ ‘Spiced’ World; Assessment of the Synthetic Cannabinoids’ Information Available Online
Authors: Zangani Caroline , Schifano Fabrizio , Napoletano Flavia , Arillotta Davide , Gilgar Liam , Guirguis Amira , Corkery John M. , Gambini Orsola , Vento Alessandro
Published: March 2020

Background:

A wide range of novel psychoactive substances (NPS) is regularly
searched and discussed online by web-based drug enthusiasts (i.e. the e-psychonauts). Among NPS,
the range of synthetic cannabinoids (SC; ‘Spice’) currently represents a challenge for governments
and clinicians.

Methods:

Using a web crawler (i.e. the NPS.Finder®), the present study aimed at assessing psychonauts’
fora/platforms to better understand the online mentions of SC.

Results:

The open-web crawling/navigating software identified here some 1,103 synthetic cannabinoids.
Of these, 863 molecules were not listed in either the international or the European NPS databases.

Conclusions:

A web crawling approach helped here in identifying a large range of unknown SC
likely to possess a misuse potential. Most of these novel/emerging molecules are still relatively
unknown. This is a reason for concern; each of these analogues potentially presents different toxicodynamic
profiles and there is a lack of docking, preclinical, and clinical observations. Strengthening
multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better
assessing SC-associated public health risks.
Biological Activities of Saussurea lappa Antioxidants Recovered by Solid–liquid, Ultrasound and Ired-Irrad®
Authors: Rajha Hiba N. , El Khoury Gisèle , El Darra Nada , Raafat Karim , Debs Espérance , Maroun Richard G. , Louka Nicolas
Published: March 2020

Background:

Saussurea lappa is a traditionally well-known plant appreciated for its biological activities and medicinal uses.

Objective:

In the present study, the recovery of antioxidants from Saussurea lappa was optimized using Response Surface Methodology (RSM). The efficiency of a newly-patented Infrared (IR) technology, Ired-Irrad®, was compared to that of the emerging ultrasound method (US) and the conventional solid liquid Water Bath (WB) extraction.

Methods:

The effects of time (t) and Temperature (T), mostly known to affect the extraction process, were tested on maximizing the Total Phenolic compounds Concentration (TPC) and the radical scavenging activity (AA). Response surface methodology was used for the optimization process.

Results:

A multiple response optimization of both time (t) and Temperature (T) was conducted, showing the best extraction conditions to be for WB: t= 43.86 min, T=33.79°C, for US: t= 65.47 min, T= 57.97°C and for IR: t= 42.5 min, T=34.19°C. The quantity of the optimally extracted polyphenols by WB, US and IR; as well as many of their bioactivities were compared. IR extraction gave the highest yield of TPC (15.3 mg GAE/g DM) followed by US (14.8 mg GAE/g DM) and lastly WB (13.9 mg GAE/g DM). The highest antioxidant and antiradical activities were also obtained by the IR treatment. The optimal IR extract inhibited the growth of Staphylococcus aureus and Escherichia coli up to 65 and 35%, respectively. Moreover, all Saussurea lappa extracts (WB, US and IR) inhibited up to 96% the production of Aflatoxin B1 (AFB1) by Aspergillus flavus.

Conclusion:

Our findings on the extraction of antioxidants from Saussurea lappa demonstrated that IR technology is an efficient novel method that can be used to extract the maximum yield of polyphenols, with the highest antioxidant, antiradical and antibacterial activities.
Withdrawal Notice: Cryptotanshinone Suppresses Liver Fibrosis by Attenuating Epithelial-Mesenchymal Transition through Targeting Hedgehog Pathway
Authors: Ren Shurong , Yue Qizhen , Wang Qiubo , Zhang Yanli , Zhang Bei
Published: March 2020

The article has been withdrawn by the Editorial office of the journal Anti-Cancer Agents in Medicinal
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Об особенностях примесного энергетического спектра арсенидов
Authors: Камилов И.К. , Даунов М.И. , Гаджиев Г.М. , Арсланов Р.К.
Published: March 2020

The impurity energy spectrum of non-doped bulk crystals of n-type GaAs, InAs, CdSnAs2, CdGeAs2 and CdTe, ZnO is investigated basing on the findings from the quantitative analysis of baric and temperature dependences of kinetic coefficients. It`s found that in the above-listed semiconductors the deep level donor center corresponds to the intrinsic defect of vacancy in the anion sublattice. The energy level positions relative to conduction band edge and the pressure coefficients of energy gaps between them and corresponded conduction band bottom are determined. The shift of deep donor center energy levels towards the depth of the conduction band is observed with a decrease in the forbidden band width in above-listed semiconductors.
Эффекты легирования сульфида свинца серебром на решеточных и оптических свойствах твердых растворов Pb-=SUB=-1-x-=/SUB=-Ag-=SUB=-x-=/SUB=-S
Authors: Садовников С.И.
Published: March 2020

Single-phase limited cubic solid solutions Pb1-xAgxS based on PbS with a metal sublattice alloyed with silver are obtained. The maximum relative content of silver in solid solutions Pb1-xAgxS reaches x = 0.15. For the first time the thermal expansion of semiconductor solid solutions Pb1-xAgxS was measured by dilatometry method in the temperature range 295-580 K. Substitution of lead atoms by silver atoms in Pb1-xAgxS leads to a decrease in the coefficient of thermal expansion associated with a change in the anharmonicity of atomic vibrations and a weak increase in the elastic properties. For single-crystal particles PbS and solid solutions Pb1-xAgxS, spatial distributions of the elastic modulus E, Poisson's ratio , and linear compressibility  as a function of the direction (hkl) are found. The reflection spectra of the synthesized powders PbS, Ag2S and Pb1-xAgxS are measured and it is shown that the replacement of lead with silver in PbS is accompanied by an increase in the width of the band gap.
Leveraging Providers’ Preferences to Customize Instructional Content in Information and Communications Technology–Based Training Interventions: Retrospective Analysis of a Mobile Phone–Based Intervention in India
Authors: Tyagi Hanu , Sabharwal Manisha , Dixit Nishi , Pal Arnab , Deo Sarang
Published: March 2020

Background

Many public health programs and interventions across the world increasingly rely on using information and communications technology (ICT) tools to train and sensitize health professionals. However, the effects of such programs on provider knowledge, practice, and patient health outcomes have been inconsistent. One of the reasons for the varied effectiveness of these programs is the low and varying levels of provider engagement, which, in turn, could be because of the form and mode of content used. Tailoring instructional content could improve engagement, but it is expensive and logistically demanding to do so with traditional training

Objective

This study aimed to discover preferences among providers on the form (articles or videos), mode (featuring peers or experts), and length (short or long) of the instructional content; to quantify the extent to which differences in these preferences can explain variation in provider engagement with ICT-based training interventions; and to compare the power of content preferences to explain provider engagement against that of demographic variables.

Methods

We used data from a mobile phone–based intervention focused on improving tuberculosis diagnostic practices among 24,949 private providers from 5 specialties and 1734 cities over 1 year. Engagement time was used as the primary outcome to assess provider engagement. K-means clustering was used to segment providers based on the proportion of engagement time spent on content formats, modes, and lengths to discover their content preferences. The identified clusters were used to predict engagement time using a linear regression model. Subsequently, we compared the accuracy of the cluster-based prediction model with one based on demographic variables of providers (eg, specialty and geographic location).

Results

The average engagement time across all providers was 7.5 min (median 0, IQR 0-1.58). A total of 69.75% (17,401/24,949) of providers did not consume any content. The average engagement time for providers with nonzero engagement time was 24.8 min (median 4.9, IQR 2.2-10.1). We identified 4 clusters of providers with distinct preferences for form, mode, and length of content. These clusters explained a substantially higher proportion of the variation in engagement time compared with demographic variables (32.9% vs 1.0%) and yielded a more accurate prediction for the engagement time (root mean square error: 4.29 vs 5.21 and mean absolute error: 3.30 vs 4.26).

Conclusions

Providers participating in a mobile phone–based digital campaign have inherent preferences for instructional content. Targeting providers based on individual content preferences could result in higher provider engagement as compared to targeting providers based on demographic variables.
An Untapped Potential in Primary Care: Semi-Structured Interviews with Clinicians on How Patient Portals Will Work for Caregivers in the Safety Net (Preprint)
Authors: Casillas Alejandra , Cemballi Anupama Gunshekar , Abhat Anshu , Lemberg Miya , Portz Jennifer D , Sadasivaiah Shobha , Ratanawongsa Neda , Semere Wagahta , Brown Arleen , Lyles Courtney Rees
Published: March 2020

BACKGROUND

Patients within safety-net settings are less likely to access health information on patient portals, despite expressed interest. Family and friends are important resources to assist these patients (ie, Medicaid recipients, older patients, patients with limited English proficiency) in navigating health systems, and provider support of the use of patient portals among these groups may also facilitate caregivers’ use of their patients’ portal.

OBJECTIVE

Because safety net providers work closely with caregivers to care for their patients, we used qualitative methods to explore safety net providers’ perspectives on portal use among caregivers for their patients, especially as there is limited literature about caregivers’ use of portals in the safety net.

METHODS

We conducted 45- to 60-min semistructured telephone interviews with providers from three large California safety-net health systems. The interviews focused on providers’ experiences with caregivers, caregiver roles, and how the portal could be leveraged as a tool to support caregivers in their responsibilities. A total of three coders analyzed the interview transcripts using both deductive and inductive approaches and established a consensus regarding major themes.

RESULTS

Of the 16 participants interviewed, 4 specialized in geriatrics, and all held a leadership or administrative role. We described themes highlighting providers’ recognition of potential benefits associated with caregiver portal use and specific challenges to caregiver engagement.

CONCLUSIONS

Providers recognized the potential for portals to improve information delivery and communication by helping caregivers assist socially and medically complex patients in the safety net. Providers in safety net sites also discussed a clear need for better ways to keep in touch with patients and connect with caregivers, yet security and privacy are perhaps of higher importance in these settings and may pose challenges to portal adoption. They noted that caregivers of patients in the safety net likely face similar communication barriers as patients, especially with respect to digital literacy, health literacy, and English proficiency. Further research is needed to assess and support caregivers’ interest and ability to access portals across barriers in health and digital literacy, and English proficiency. Portal platforms and health systems must also address specific strategies to uphold patient preferences while maintaining privacy and security.
Sudden Infant Death Syndrome on Facebook: Qualitative Descriptive Content Analysis to Guide Prevention Efforts (Preprint)
Authors: Pretorius Kelly , Choi Eunju , Kang Sookja , Mackert Michael
Published: March 2020

BACKGROUND

Sudden unexpected infant death (SUID), which includes the diagnosis of sudden infant death syndrome (SIDS), is a leading cause of infant mortality in the United States. Despite prevention efforts, many parents continue to create unsafe infant sleep environments and use potentially dangerous infant sleep and monitoring devices, ultimately leading to sleep-related infant deaths. Analyzing Facebook conversations regarding SIDS may offer a unique maternal perspective to guide future research and prevention efforts.

OBJECTIVE

This study aims to describe and analyze conversations among mothers engaged in discussions about SIDS on a Facebook mother’s group. We were interested in understanding maternal knowledge of SIDS, identifying information sources for SIDS, describing actual infant sleep practices, exploring opinions regarding infant sleep products and monitoring devices, and discovering evidence of provider communication regarding SIDS.

METHODS

We extracted and analyzed 20 posts and 912 comments from 512 mothers who participated in a specific Facebook mother’s group and engaged in conversations about SIDS. There were 2 reviewers who coded the data using qualitative descriptive content analysis. Themes were induced after discussion among researchers and after the study objectives were addressed.

RESULTS

The theme of social support emerged, specifically informational and emotional support. A variety of informational sources for SIDS and safe sleep were identified, as was a continuum of infant sleep practices (ranging from unsafe to safe sleep per the American Academy of Pediatrics standards). There was widespread discussion regarding infant sleep products and monitoring devices. Embedded within conversations were (1) confusion among commonly used medical terminology, (2) the practice of unsafe infant sleep, (3) inconsistency in provider communication about SIDS, and (4) maternal anxiety regarding SIDS.

CONCLUSIONS

We uncovered new findings in this analysis, such as the commonality of infant sleep products and monitoring devices and widespread maternal anxiety regarding SIDS. Additionally, mothers who participated in the Facebook group provided and received informational and emotional support regarding SIDS via this social media format. Such results can guide future prevention efforts by informing health communication regarding SUID and safe sleep. Future provider and public health agency communication on the topic of SUID and safe sleep should be simple and clear, address infant sleep products and monitoring devices, address maternal anxiety regarding SIDS, and address the common practice of unsafe sleep.
Reinforcement Learning for Clinical Decision Support in Critical Care: Comprehensive Review (Preprint)
Authors: Liu Siqi , See Kay Choong , Ngiam Kee Yuan , Celi Leo Anthony , Sun Xingzhi , Feng Mengling
Published: March 2020

BACKGROUND

Decision support systems based on reinforcement learning (RL) have been implemented to facilitate the delivery of personalized care. This paper aimed to provide a comprehensive review of RL applications in the critical care setting.

OBJECTIVE

This review aimed to survey the literature on RL applications for clinical decision support in critical care and to provide insight into the challenges of applying various RL models.

METHODS

We performed an extensive search of the following databases: PubMed, Google Scholar, Institute of Electrical and Electronics Engineers (IEEE), ScienceDirect, Web of Science, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Excerpta Medica Database (EMBASE). Studies published over the past 10 years (2010-2019) that have applied RL for critical care were included.

RESULTS

We included 21 papers and found that RL has been used to optimize the choice of medications, drug dosing, and timing of interventions and to target personalized laboratory values. We further compared and contrasted the design of the RL models and the evaluation metrics for each application.

CONCLUSIONS

RL has great potential for enhancing decision making in critical care. Challenges regarding RL system design, evaluation metrics, and model choice exist. More importantly, further work is required to validate RL in authentic clinical environments.
Virtual Reality Cognitive Training Among Individuals With Alcohol Use Disorder Undergoing Residential Treatment: Pilot Randomized Controlled Trial (Preprint)
Authors: Gamito Pedro , Oliveira Jorge , Matias Marcelo , Cunha Elsa , Brito Rodrigo , Lopes Paulo Ferreira , Deus Alberto
Published: March 2020

BACKGROUND

Alcohol use disorder (AUD) has been associated with diverse physical and mental morbidities. Among the main consequences of chronic and excessive alcohol use are cognitive and executive deficits. Some of these deficits may be reversed in specific cognitive and executive domains with behavioral approaches consisting of cognitive training. The advent of computer-based interventions may leverage these improvements, but randomized controlled trials (RCTs) of digital interactive-based interventions are still scarce.

OBJECTIVE

The aim of this study is to explore whether a cognitive training approach using VR exercises based on activities of daily living is feasible for improving the cognitive function of patients with AUD undergoing residential treatment, as well as to estimate the effect size for this intervention to power future definitive RCTs.

METHODS

This study consisted of a two-arm pilot RCT with a sample of 36 individuals recovering from AUD in a therapeutic community; experimental group participants received a therapist-guided, VR-based cognitive training intervention combined with treatment as usual, and control group participants received treatment as usual without cognitive training. A comprehensive neuropsychological battery of tests was used both at pre- and postassessments, including measurement of global cognition, executive functions, attention, visual memory, and cognitive flexibility.

RESULTS

In order to control for potential effects of global cognition and executive functions at baseline, these domains were controlled for in the statistical analysis for each individual outcome. Results indicate intervention effects on attention in two out of five outcomes and on cognitive flexibility in two out of six outcomes, with effect sizes in significant comparisons being larger for attention than for cognitive flexibility. Patient retention in cognitive training was high, in line with previous studies.

CONCLUSIONS

Overall, the data suggest that VR-based cognitive training results in specific contributions to improving attention ability and cognitive flexibility of patients recovering from AUD.

CLINICALTRIAL

ClinicalTrials.gov NCT04505345; https://clinicaltrials.gov/show/NCT04505345
Theories Informing eHealth Implementation: Systematic Review and Typology Classification (Preprint)
Authors: Heinsch Milena , Wyllie Jessica , Carlson Jamie , Wells Hannah , Tickner Campbell , Kay-Lambkin Frances
Published: March 2020

BACKGROUND

Theory-guided approaches to implementation science have informed translation efforts and the acceptance of eHealth (digital health) interventions in clinical care. However, there is scarce evidence on which theories are best suited to addressing the inherent complexity of eHealth implementation.

OBJECTIVE

The objectives of this systematic review are to identify theories that inform and explain eHealth implementation and to classify these theories using the typology by Sovacool and Hess for theories of sociotechnical change.

METHODS

An electronic search was conducted in the PsycINFO, MEDLINE, Embase, CINAHL, Scopus, Sociological Source Ultimate, Web of Science, ABI/INFORM, EBSCO, and ProQuest databases in June 2019. Studies were included if they were published between 2009 and June 2019; were written in English; reported on empirical research, regardless of study or publication type; reported on one or more theories in the context of eHealth implementation; and were published in a peer-reviewed journal. A total of 2 reviewers independently assessed the titles, abstracts, and full texts. Theories identified were classified using a typology for theories of sociotechnical change, which was considered a useful tool for ordering and analyzing the diverse theoretical approaches as a basis for future theory building.

RESULTS

Of the 13,101 potentially relevant titles, 119 studies were included. The review identified 36 theories used to explain implementation approaches in eHealth. The most commonly used approaches were the Technology Acceptance Model (TAM) (n=33) and the Unified Theory of Acceptance and Use of Technology (UTAUT) (n=32). These theories were primarily concerned with individual and interpersonal elements of eHealth acceptance. Less common were theories that reflect the various disorderly social processes and structural dimensions of implementation, such as the normalization process theory (n=17) and the structuration theory (n=6).

CONCLUSIONS

Theories currently informing the implementation of eHealth interventions predominantly focus on predicting or explaining end-user acceptance. Theoretical perspectives that capture the dense and intricate relationships and structures required to enact sustainable change are less well represented in the eHealth literature. Given the growing acknowledgment of the inherent complexity of eHealth implementation, future research should develop and test models that recognize and reflect the multidimensional, dynamic, and relational nature of this process.

CLINICALTRIAL
Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite
Authors: Hasanuddin Norilyani Izzati , Dzulkifli Nur Nadia , Sarijo Siti Halimah , Ghazali Sheikh Ahmad Izaddin Sheikh Mohd
Published: March 2020

In this present work, herbicide named 2-methyl-4-chlorophenoxy acetic acid (MCPA) was intercalated into the graphite oxide through ion-exchange method to produce a MCPA-GO nanocomposite as an herbicide delivery system. The formation of MCPA-GO nanocomposite was confirmed by using PXRD, Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), UV-Visible Spectroscopy and Accelerated Surface Area Surface (ASAP). As for PXRD pattern, there was increasing in the basal spacing of the nanocomposite from the graphite oxide which by 9.3 Å to 9.7 Å indicated that MCPA has succesfully inserted into the interlayers of the graphite oxide. Meanwhile, FTIR spectrum shown the appearance of a new peak in MCPA-GO nanocomposite at 1308 cm-1 represent the functional group of carboxylate (COO-).  This peak is very necessary for the confirmation of anionic form of MCPA inserted into the interlayers of graphite oxide. The controlled release property was also done for further investigation by using various aqueous medias to determine the percentage release of MCPA from the nanocomposite. The percentage of herbicide release in Na3PO3 solution was higher than in Na2CO3 and NaCl solution, proved that the release properties exhibits the potential application of graphite oxide as effective nanocarrier of herbicides. MCPA-GO nanocomposite suggested to be most promising herbicide since it can lower the toxicity of precursor MCPA, high biocompability, and more efficient in herbicide delivery system.
α-Glucosidase Inhibitory and A Leptospermone Derivative from Rhodomyrtus tomentosa
Authors: Ferlinahayati Ferlinahayati , Alfarado Daniel , Eliza Eliza , Untari Budi
Published: March 2020

One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and n-butanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC50 13.49 and 19.29 μg/mL) compare to acarbose and n-hexane fraction (IC50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data. The α-glucosidase inhibition of rhodomyrtosone D (IC50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor.
ZNO-Ag/PS and ZnO/PS Films for Photocatalytic Degradation of Methylene Blue
Authors: Naji Hassan Khuder , Oda Amjed Mirza , Abdulaljeleel Wesam , Abdilkadhim Hussein , Hefdhi Rawaa
Published: March 2020

Two films of ZnO-Ag/polystyrene (ZnO-Ag/PS) and ZnO/polystyrene (ZnO/PS) have been prepared to evaluate the photodegradation ability of stabilized catalysts. The efficiency of ZnO improved against recombination of electron-hole pair by modification of catalyst surface with Ag photodeposition to be more resistant towards photocorrosion. ZnO-Ag catalyst was characterized by SEM and EDS analysis to show high roughness of this catalyst and Ag deposited on the surface was 2% (molar ratio). ZnO-Ag/PS and ZnO/PS composites were made as films and were then analyzed by FTIR spectra that showed the interaction of ZnO and ZnO-Ag with polystyrene appeared in the range of 400–620 cm–1, XRD pattern indicated the presence of Ag nanoparticles on the surface of ZnO and ZnO/PS film has maximum absorbance at 376 nm in UV-VIS spectra. This value shifted to 380 nm because of the photodeposition. The photocatalytic reaction was depicted using methylene blue (MB) in the UV-irradiation action of stacked films in MB solution. The result showed that both ZnO-Ag/PS and ZnO/PS films gave efficiency to remove MB by 97% and 70%, respectively. The reusability test of the films showed that ZnO-Ag/PS was more resistant than ZnO/PS. The presence of Ag also increased the efficiency in photodegradation and resistance against photocorrosion.
The Translation of English Financial Humor into Spanish: Cognitive, Linguistic and Pragmatic Issues
Authors: Mateo José , Mateo-Guillén Copelia
Published: March 2020

This paper addresses the translation of financial humor from English into Spanish. However, from a linguistic and pragmatic angle, both languages appear to be worlds apart in the way they approach this specialist language and discourse. English often resorts to various linguistic and communicative solutions in order to allow non-specialist readers understand the intricacies of abstract professional discourses as is the case with financial language. At the other end, Spanish tends to maintain an academic and professional tone whoever the interlocutors. Consequently, non-specialist Spanish-speaking users find financial terms and procedures intricate and difficult to understand. Humor is commonly and largely used in financial English to ease its conceptual load and favor its conceptual and linguistic understanding. Spanish, at the other extreme, very rarely uses this linguistic solution in professional financial settings.
VANILLIC ACID INHIBITS LUNG CARCINOGENESIS BY MODULATES GLYCOPROTEIN ABNORMALITIES, MEMBRANE-BOUND ENZYMES, AND INFLAMMATORY MARKERS
Authors: VELLI SATHESH KANNA , THIRUVENGADAM DEVAKI
Published: March 2020

Objective: The current plan was accompanied to explicate the possible protective role of vanillic acid (VA), on modification in lipid peroxidation, inflammatory cytokines, membrane-bound enzymes, and glycoconjugates during B(a)P induced lung cancer in Swiss albino mice.

Methods: Benzo(a)pyrene was administered orally (50 mg/kg b. wt) to induce lung cancer in Swiss albino mice. lipid peroxidation, serum marker enzymes, inflammatory cytokines, membrane-bound ATPases and protein-bound carbohydrate components (Hexose, hexosamine, sialic acid and fucose) and Mast cells and PAS staining were carried out.

Results: Lung cancer possessing animals exhibited increased levels of lipid peroxidation, ADA, AHH, γ-GT, 5’-NT, LDH, cytokines such as TNF-α and IL-1β, protein-bound carbohydrate components (protein-hexose, hexosamine, sialic acid, and fucose) also diminished activity of membrane-bound ATPases (Na+/K+ATPases, Ca2+ATPases, and Mg2+ATPase). Treatment with VA significantly ameliorated all these activities.

Conclusion: Overall, the present study evidence to the VA has effective anti-inflammatory in addition to free radical scavenging activity for the duration of lung carcinogenesis in Swiss albino mice.
Alaíde Foppa
Authors: Poniatowska Elena
Published: March 2020

Alaíde Foppa
La gira mamal de la Coatlicue
Authors: Rodríguez Jesusa
Published: March 2020

La gira mamal de la Coatlicue
ANALYSIS OF THE CHARACTERISTICS AND DEVELOPMENT DISPARITIES AMONG DISTRICTS/CITIES IN EAST NUSA TENGGARA PROVINCE
Authors: Sagajoka Estherlina , Banda Falentina Lucia
Published: March 2020

This study aims to review the regional characteristics and the development disparities among districts/cities in East Nusa Tenggara Province. This quantitative descriptive study used the Klassen typology and Williamson index using PDRB time-series data per capita and economic growth rate during 2013-2018. The analysis of Klassen typology shows that Kupang City, East Flores Regency, Sikka Regency, and Ende Regency include the developing and fast-growing regions. Kupang Regency, Timur Tengah Selatan Regency, East Sumba Regency include in the developing, but depressed regions. Belu Regency, Alor, Lembata, Manggarai, Ngada, West Manggarai, Rote Ndao, East Manggarai, Southwest Sumba, Malacca, Nagekeo, Central Sumba, and Sabu Raijua District including in the potential and fast-growing areas, while West Sumba Regency and Regency North Middle East are categorized in the underdeveloped regions. The calculation of the Williamson Index of districts/cities in East Nusa Tenggara Province is approximately 0.0 - 0.11 in every district. This shows that the revenue of East Nusa Tenggara Province is evenly distributed in every district, except Kota Kupang which of value is nearly 1, which is 0.63%. This reflected that the revenue of Kupang City is not evenly distributed compared to other districts in Nusa Tenggara Timur Province.
Quantum Speedup Based on Classical Decision Trees
Authors: Beigi Salman , Taghavi Leila
Published: March 2020

Lin and Lin \cite{LL16} have recently shown how starting with a classical query algorithm (decision tree) for a function, we may find upper bounds on its quantum query complexity. More precisely, they have shown that given a decision tree for a function f:{0,1}n→[m] whose input can be accessed via queries to its bits, and a guessing algorithm that predicts answers to the queries, there is a quantum query algorithm for f which makes at most O(GT) quantum queries where T is the depth of the decision tree and G is the maximum number of mistakes of the guessing algorithm. In this paper we give a simple proof of and generalize this result for functions f:[ℓ]n→[m] with non-binary input as well as output alphabets. Our main tool for this generalization is non-binary span program which has recently been developed for non-binary functions, and the dual adversary bound. As applications of our main result we present several quantum query upper bounds, some of which are new. In particular, we show that topological sorting of vertices of a directed graph G can be done with O(n3/2) quantum queries in the adjacency matrix model. Also, we show that the quantum query complexity of the maximum bipartite matching is upper bounded by O(n3/4m+n) in the adjacency list model.
EPIDEMIOLOGY AND SURVIVAL ANALYSIS OF MOUTH AND OROPHARYNGEAL CANCER PATIENTS TREATED AT A PUBLIC HOSPITAL IN RIO DE JANEIRO, BRAZIL
Authors: Nogueira de Paula Barros Jackeline
Published: March 2020

AbstractMouth and oropharyngeal cancers (CAs) are considered to be global public health problems, with high psychosocial impacts and high costs. Developing an epidemiological profile and examining the survival rate among patients with CAs of the mouth and oropharynx are important for the development of public policy. Therefore, this retrospective study aimed to evaluate mouth and oropharyngeal CA patients treated at the Municipal Hospital Salgado Filho in Rio de Janeiro, Brazil between 2007 and 2017. Patient data regarding gender, age, ethnicity, diagnosis, anatomical site affected by the tumor, and habits were obtained from patient records and reports, and data regarding the deaths of patients were obtained from records and the Mortality Information System. After tabulation, data were descriptively analyzed using the Kaplan-Meier survival curve, and the log-rank test was used for the comparison of variables. Survival rates at 5 and 8 years were 71.1% and 48.8%, respectively. There were no significant differences among survival rates according to age, sex, ethnicity, or the anatomical location of tumors. The survival rates among mouth and oropharyngeal CA patients in this study were comparable with the results reported in developed countries.Keywords: Oral neoplasms, epidemiology, survival rate;
ONTOLOGICAL MISCONCEPTION IN MATHEMATICS TEACHING IN ELEMENTARY SCHOOLS
Authors: Kusmaryono Imam , Basir Mochamad Abdul , Saputro Bagus Ardi
Published: March 2020

Elementary school teachers in Indonesia are required to master many subjects to be taught to their students. It is undeniable that the teachers’ mastery of knowledge (material) in some subjects inadequate. Therefore, it is worth to argue that there was a misconception in mathematics teaching in elementary schools. This research was designed using a qualitative approach. The participants of this study were 30 elementary school teachers in Semarang city area, Central Java province, Indonesia. The research data were obtained through questionnaires, and interviews. The purpose of the study was to discuss the types and causes of the misconception of mathematics teaching in elementary schools. Alternative solutions were also presented to problem-solving so that misconceptions do not occur anymore in mathematics teaching. The findings show that, teachers evenly experience types of misconceptions: (1) pre-conception, (2) under-generalization, (3) over-generalization, (4) modelling error, (5) prototyping error; and (6) process-object error in teaching mathematics in elementary schools. Some misconceptions have taken root and are difficult to remove, called "ontological misconceptions" because of teachers' years of belief that the knowledge they received was true when in fact it was not quite right.
ADVOCACY APPROACH WITH OPEN-ENDED PROBLEMS TO MATHEMATICAL CREATIVE THINKING ABILITY
Authors: Ibrahim Ibrahim , Widodo Sri Adi
Published: March 2020

The purpose of this study is to find out the increase in students' ability to think creatively in advocacy learning by using open-ended problems. This type of research is an experiment with nonequivalent control group design. The sample in this study were 72 students taken using random sampling techniques. The variables in this study are learning models, mathematical creative thinking abilities, and general mathematics abilities. The instruments used in this study were creative thinking tests and general mathematics tests. Data analysis techniques used in this study are statistical inference using the Mann-Whitney test and one-way ANOVA. The results showed that students who were treated with an advocacy approach by presenting open-ended problems improved their mathematical creative thinking abilities better when compared with conventional learning.
El aprovechamiento de las redes sociales en la educación
Authors: Villamizar-Briceño Solandy
Published: March 2020

El propósito fundamental de esta investigación, fue valorar el ejercicio de la lectoescritura mediado por las aplicaciones informáticas para la edición de texto, vinculadas a las redes sociales, que realizan los estudiantes informantes, como un referente para la conformación de constructos teóricos que permitan la comprensión de mecanismos emergentes; enmarcada en el paradigma cualitativo y con el apoyo de la etnometodología, siguiendo un diseño de campo. El escenario en el que se desarrolló la investigación fueron tres instituciones educativas de Cúcuta, Colombia, a donde pertenecen los estudiantes informantes claves: Colegio Rafael Uribe Urbe (carácter oficial), el Colegio Calasanz (carácter privado) y la Universidad Francisco de Paula Santander (institución pública de educación superior) Las técnicas para la recolección de la información, fueron la observación y la entrevista no estructurada; además como instrumentos se empleó un formato para registro de situaciones observables, teniendo en cuenta, además los símbolos verbales y no verbales de los informantes dentro del contexto de estudio y un guión con una serie de preguntas iniciales. La información que se recolectó, se organizó con el objeto de extraer lo más importante concerniente al fenómeno investigado, de acuerdo al proceso de categorización codificación, se realizó su análisis, a la luz de los conceptos claves de la etnometodología: desarrollando finalmente la teorización sobre los hallazgos emergentes.
Elementos a considerar en la enseñanza del registro semiótico de las figuras en los primeros ciclos de la educación básica
Authors: Marmolejo-Avenia Gustavo Adolfo
Published: March 2020

La figura desempeña en el aprendizaje de la geometría un papel determinante. Pero, muchos estudiantes de forma espontánea no recurren a las posibilidades que brindan estas representaciones al intentar resolver problemas geométricos. En consecuencia, la enseñanza de las posibilidades que brinda este registro de representación es un asunto a considerar en la enseñanza de las matemáticas. En esta conferencia se pretende llamar la atención sobre la complejidad que subyace en la discriminación y designación de subfiguras y sub-configuraciones en una configuración geométrica.
Evaluación de la calidad en la prestación de servicios de Salud por medio de series de tiempo enmarcado en la metodología Seis Sigma
Authors: Pérez Pulido Miguel Oswaldo , Merli Giampaolo Orlandoni , Ramoni Perazzi Josefa , Valbuena Vence Miguel
Published: March 2020

Dada su importancia, la salud en Colombia es un tema fundamental en los programas de gobierno tanto a nivel nacional, como regional y local. Garantizar el acceso a servicios de salud de calidades una de las condiciones necesarias para la reducción de la pobreza y de la desigualdad en el país. Conscientes de esta necesidad, las autoridades del ESE Hospital Lázaro Hernández (HLH),(San Alberto, Departamento del Cesar, Colombia) se proponen elevar la calidad de los servicios que dicho ente proporciona a la comunidad, la cual se caracteriza por tener altos niveles de pobreza, además de una alta incidencia de enfermedades tropicales y elevado porcentaje de población flotante procedente de tres diferentes departamentos (Cesar, Norte de Santander, Santander), debido a su ubicación geográfica fronteriza. Objetivo: Contribuir a mejorar la calidad de los servicios de salud de dicho centro asistencial a través de la aplicación de la metodología Seis Sigma. Métodos: Estudio transversal sobre percepción de la calidad en servicios de salud, donde se presentan los avances preliminares de la investigación, abordando temas de calidad en salud, como el comportamiento de los tiempos de espera y el número de pacientes atendidos en el área de urgencias durante el año 2015; los resultados de la medición de percepción de calidad por los usuarios del Hospital frente a la atención en las áreas de urgencias y consulta externa, recabados mediante la encuesta SERVQUAL, instrumento que mide la percepción de calidad en servicios de salud. La población objetivo está conformada por los pacientes atendidos durante los meses de marzo y abril de 2015 en las áreas de urgencias y consulta externa del HLHL. Los resultados obtenidos se basan en el análisis de las series de tiempos de espera y número de pacientes atendidos, para evaluar la percepción de calidad en atención, usando la herramienta computacional Statgraphics XVI. Resultados: La calificación global de percepción, permite concluir que alrededor del 50% de los pacientes tienen percepciones bajas en las dimensiones evaluadas de calidad de los servicios prestados por el HLHL
Diagnóstico y plan de gestión de manejo ambiental mina didáctica del SENA Facultad - Área de ingeniería
Authors: Monguí-Galvis Ana María , Puentes-Balaguera Edwin Alexander , Ortega Román
Published: March 2020

Con el fin de dar cumplimiento a la Legislación existente en Colombia en materia ambiental, se hace necesario implementar planes, programas, políticas, para generar una cultura ambiental, adecuada a las necesidades reales al área de explotación del Centro Nacional Minero CNM, Mina Didáctica del SENA, donde se efectuó un diagnóstico de las condiciones ambientales actuales, y se tomaron medidas que generan el mejoramiento de las circunstancias del desarrollo de la actividad minero ambiental y educativa, desarrollada por el CNM del SENA.
Propuesta para un currículo transversal e interdisciplinar para matemáticas
Authors: Jaimes  Suáreza Sara
Published: March 2020

Resumen: Por lo anterior esta investigación tiene como objetivo Desarrollar un macroproyecto curricular interdisciplinar y transversal en el área de matemáticas, para post primaria para el Cer La Laguna de Silos. Se aplica el enfoque filosófico de la Investigación cualitativa y se emplea un estudio de caso cualitativo ya que “constituye una descripción y análisis a profundidad de un sistema” (Valenzuela y Flórez 2012. p.90). Se sustenta con base en antecedentes internacionales, nacionales, locales, teorías que hablan de currículo, escuela activa, transversalidad e interdisciplinariedad. Se tomó como muestra la docente de matemáticas, la directora y cuatro estudiantes, uno de cada grado de sexto a noveno. Se aplicaron, como instrumentos de recolección de la información, dos entrevistas semiestructurada, una al inicio del proceso a todos los participantes de la investigación y una al finalizar a los estudiantes; de igual forma se hizo observación a través de una ficha en la que se registraba el trabajo con la guía transversal de matemáticas haciendo uso de los computadores. Se finaliza con la presentación de resultados y las conclusiones que se triangulan con las teorías y los objetivos.Palabras clave Transversalidad, interdisciplinariedad, currículo.Abstract: Therefore, this research aims to develop an interdisciplinary and crosscurricular macroproject in the area of mathematics, for post-primary for Cer La Laguna de Silos. The philosophical approach of qualitative research is applied and a qualitative case study is used since “it constitutes a description and in-depth analysis of a system” (Valenzuela and Flórez 2012. p.90). It is based on international, national and local backgrounds, theories that speak of curriculum, active school, transversality and interdisciplinarity. The math teacher, the principal and four students were taken as a sample, one from each grade from sixth to ninth grade. Two semistructured interviews were applied as instruments of information collection, one at the beginning of the process to all the participants of the research and one at the end of the students; In the same way, an observation was made through a file in which the work was recorded with the transversal guide of mathematics making use of the computers. It ends with the presentation of results and the conclusions that are triangulated with the theories and objectives.Keywords Transversality, interdisciplinarity, curriculum.
La cultura organizacional en la Universidad de Santander Cúcuta
Authors: Ortega-Sierra Sandra , Vergel-Ortega Mawency , Goméz-Colmenares Carlos Alberto
Published: March 2020

La investigación analiza la Cultura Organizacional de la Universidad de Santander, sede Cúcuta. El estudio es de naturaleza descriptiva, exploratoria y correlacional. El análisis descriptivo, comprende la caracterización de aspectos de la cultura de la organización, a partir de los datos obtenidos en la aplicación del instrumento. El análisis exploratorio y correlacional, se realizó basado en los análisis estadísticos factorial, regresión y caminos. Responde a preguntas ¿Cómo percibe la Universidad de Santander? ¿Qué espera de sus profesores? ¿Considera que se ha posicionado en la región?.
Exploración ética como aproximación a la educación integral en jóvenes de la Universidad Francisco de Paula Santander
Authors: Solano-Guerrero Ilva Rosa , Rubio-Ortega Jesus David
Published: March 2020

El presente artículo tiene como objetivo presentar un informe de la investigación realizada con un grupo de jóvenes universitarios inscritos en diversos programas académicos de la universidad Francisco de Paula Santander, entre ellos hombres y mujeres con edades entre los 18 y 25 años, con quienes se orientó un seminario taller denominado “compromiso ético de la juventud”, quienes a través de una encuesta se les interrogó sobre temáticas que corresponden al pensamiento y actuar desde un componente axiológico. El diseño investigativo se presenta en un nivel explicativo, permitiendo identificar la variedad de pensamientos en lo que respecta a situaciones que tienen que ver con el comportamiento humano, la ética y los valores. Además experimentando cómo el joven del siglo XXI da razones propias del hombre de hoy y que lo hacen diferente con toda seguridad de los antiguos, llegando a la conclusión que el hombre actual hace parte de un momento histórico denominado “El postmodernismo”, como un proceso en el que se operan cambios de tendencia, en provecho del principio que conduce al libre desarrollo de la personalidad, un joven que no cesa de conquistar nuevas esferas: la educación, la enseñanza, el tiempo libre, el deporte, la moda, los horarios, el trabajo, la comunicación, la tecnología, entre otras. Conduciendo a la transformación de un pensamiento y actuar que inicia en el individuo, se permea en la familia, se extiende a la sociedad dejando la moralidad en manos de la legalidad: por ende es la educación actual quien tiene el compromiso ético de reestructurar y orientar el quehacer pedagógico, atendiendo a los principios que  imperan en la Ley y que conducen la formación de los jóvenes hacia la integralidad de su sercomo hombres en pro de una mejor sociedad.