bluuebunny/crossref_metadata_2025 huggingface dataset:
Emerging Trends in the Delivery of Resveratrol by Nanostructures: Applications of Nanotechnology in Life Sciences
Authors: Chopra Hitesh , Bibi Shabana , Islam Fahadul , Ahmad Syed Umair , Olawale Oluwaseyi Abraham , Alhumaydhi Fahad A. , Marzouki Riadh , Baig Atif Amin , Emran Talha Bin
Published: March 2022

Resveratrol (RES) is a stilbene group of natural polyphenolic compounds in trees, peanuts, and grapes. RES is revealed with anticancer, antioxidant, anti‐inflammatory, and cardioprotective effects. Though it is proven with prominent therapeutic activity, low aqueous solubility, poor bioavailability, and short half‐life had hindered its use to exploit the potential. Also, the first‐pass metabolism and undergoing enterohepatic recirculation are obscure in the minds of researchers for their in vitro studies. Many approaches have been investigated and shown promising results in manipulating their physicochemical properties to break this barrier. Nanocarriers are one of them to reduce the first‐pass metabolism and to overcome other hurdles. This article reviews and highlights such encapsulation technologies. Nanoencapsulated RES improves in vitro antioxidant effect, and this review also highlights the new strategies and the concept behind how resveratrol can be handled and implemented with better therapeutic efficacy.
Early Warning and Clinical Epidemiological Characteristics of Lung Injury in the Treatment of Infectious Staphylococcus aureus Sepsis by Vancomycin Based on Adaptive Niche Genetic Algorithm and Pulmonary Ultrasound Images
Authors: Huang Xue , Wang Nan , Duanmu Ningjie , Fu Li
Published: March 2022

Adaptive niche genetic algorithm (ANGA) and lung ultrasound were combined, the death warning mathematical model was established for patients with sepsis-lung injury, and the epidemiological characteristics were analyzed to explore the efficacy of Vancomycin in the treatment of sepsis-lung injury. First, 88 sepsis patients with lung injury were selected as the research objects. General clinical data and pulmonary ultrasound results were collected. On this basis, epidemiological analysis was carried out, and the death warning model of patients with sepsis-lung injury was established based on ANGA algorithm. Then, the total cure rate, Staphylococcus aureus (SA) clearance rate, methicillin-resistant SA (MRSA) clearance rate, and the incidence of adverse reactions after intravenous infusion of Vancomycin were analyzed. The results showed that the ANGA mathematical model combined with the random forest (RF) classifier proposed had better classification effect and robustness relative to the traditional principal component analysis and NGA. The early warning accuracy of the proposed ANGA + RF mathematical model was higher than 95% in contrast to that of the APACHE-II score and the SOFA score. Compared with patients in the severe group, the MRSA infection rate and the levels of procalcitonin (PCT), C-reactive protein (CRP), and activated partial thromboplastin time (APTT) of SA sepsis-lung injury patients were greatly reduced, while thrombin time (TT) and D-D dimer in the death group were considerably increased (p < 0.05), and the PLT level was greatly reduced (p < 0.05). In addition, the total cure rate, SA clearance rate, and MRSA clearance rate of Vancomycin-treated SA sepsis-lung injury patients were significantly increased (p < 0.05) compared with patients in the conventional treatment control group. However, the probability of adverse reactions was increased notably (p < 0.05). ANGA combined with RF classifier can improve the accuracy of death warning in patients with sepsis-lung injury. Vancomycin can effectively eliminate MRSA infection rate in patients with sepsis-lung injury and improve the treatment effect of patients.
Influence of Water-Resisting Layer Thickness on Fracture Evolution in Karst Tunnel and Control Measures
Authors: Liu Chun , Jiang Congying
Published: March 2022

In this paper, a series of studies are carried out on the hidden karst encountered in the excavation of Baziling tunnel. In this paper, the safe thickness of the water-resisting layer in a hidden karst cave and tunnel is studied by means of engineering geological investigation, numerical simulation, and neural network. The numerical calculation model is established through the geological survey. Innovate to use BP neural network and differentiation algorithm to inverse the rock mechanical parameters. By analyzing the influence of different thicknesses of the water-resisting layer on the deformation and failure of surrounding rock, the final thickness of the water-resisting layer is obtained. At the same time, the influence of water pressure on the thickness of the water-resisting layer is studied, and the treatment scheme under different water pressure is finally determined.
Method for Fuzzy Number Intuitionistic Fuzzy Multiple Attribute Decision Making and Its Application to Blended Classroom Teaching Reform Effect Evaluation
Authors: Sun Xia
Published: March 2022

With the continuous development of mobile Internet and educational technology, the deep integration of education and Internet has a great impact on the education concept and teaching mode. The mixed teaching based on Rain Classroom is the specific application of new educational technology in the teaching of Internet plus education. Most of the students in ethnic universities come from the central and western ethnic regions. In addition, the evaluation of blended classroom teaching reform effect is looked as the classical multiple attribute decision making (MADM). We extend the dual MSM (DMSM) operator with fuzzy number intuitionistic fuzzy numbers (FNIFNs) to build the fuzzy number intuitionistic fuzzy dual MSM (FNIFDMSM) operator and fuzzy number intuitionistic fuzzy weighted DMSM (FNIFWDMSM) equation in this study. A few MADM operators are built with FNIFWDMSM operator. Finally, taking blended classroom teaching reform effect evaluation as an useful example, this paper illustrates the depicted approach.
Research on Audit Opinion Prediction of Listed Companies Based on Sparse Principal Component Analysis and Kernel Fuzzy Clustering Algorithm
Authors: Zeng Sen , Li Yanru , Li Yaqin
Published: March 2022

The prediction of audit opinions of listed companies plays a significant role in the security market risk prevention. By introducing machine learning methods, many innovations can be implemented to improve audit quality, lift audit efficiency, and cultivate the keen insight of auditors. However, in a realistic environment, category imbalance and critical feature selection exist in the prediction model of company audit opinions. This paper firstly combines batched sparse principal component analysis (BSPCA) with kernel fuzzy clustering algorithm (KFCM) and proposes a sparse-kernel fuzzy clustering undersampling method (S-KFCM) to deal with the imbalance of sample categories. This method adopts the kernel fuzzy clustering algorithm to down-sample the normal samples, and their features are extracted from abnormal sample sets based on the group sparse component method. The sparse normal sample set can maintain the original distribution space structure and highlight the classification boundary samples. Secondly, considering the company’s characteristic attributes and data sources, 448 original variables are grouped, and then BSPCA is used for feature screening. Finally, the support vector machine (SVM) is adopted to complete the classification prediction. According to the empirical results, the SKFCM-SVM model has the highest prediction accuracy.
Changes of Class Opinion Leaders under the Mode of Fujian-Taiwan Cooperation in Running Schools Based on the Perspective of IoT Intelligent Analysis
Authors: Ji Feng , Lin Shengliang , Lin Dan
Published: March 2022

Based on the perspective of IoT intelligent analysis of the 2017 grade advertising class of Fujian-Taiwan cooperation School of Communication College of Fujian Normal University before and after going to Taiwan, this paper studies the impact of Fujian-Taiwan cooperation on the class network by comparing the advertising professional classes that do not accept the Fujian-Taiwan cooperation. From the overall network density of the class, the use of WeChat promotes the information flow of the whole network; Fujian-Taiwan cooperation in running schools significantly improves the class cohesion of Fujian-Taiwan classes; the cohesion of professional classes in the school-based department without the cooperation between Fujian and Taiwan has not been improved. From the perspective of centrality analysis and structural holes: the experimental group and the control group before going to Taiwan have the characteristics of partial female and class committee, and the excellent academic performance is not the necessary condition for the opinion leaders of convention number; the characteristics of the opinion leaders of the control group in the two periods before and after going to Taiwan have not changed a lot, with girls and class committee as the main characteristics; after going to Taiwan, the characteristics of opinion leaders in the experimental group changed greatly, with more boys, more excellent students, and less importance of class committee.
The Influence of Mixed Teaching Mode on the Learning Effects of Psychology Students’ Experiment Course in Higher Vocational Colleges
Authors: Quan Haiying , Guo Zimeng , Ni Rongjing , Li Chen , Deng Xin
Published: March 2022

In this paper, we are going to analyze the influence of mixed teaching mode on the teaching effect of psychology students’ experiment courses in higher vocational colleges. To realize and verify these claims, 80 psychology students of grade 2020 in our school were selected for observation. Class 1 of the psychology major in our school was randomly selected as the observation group (n = 40) and Class 2 as the control group (n = 40). The mixed teaching mode and the traditional teaching mode were adopted, respectively. After intervention, the experimental examination results, experimental report score, general evaluation results of the experiment, and experimental pass rate of the observation group were higher than those before intervention

P
<
0.05

. The control group had no significant change before and after intervention

P
>
0.05

. The experimental examination results, experimental report score, general evaluation results of the experiment, and experimental pass rate of the observation group were all higher than those of the control group, with statistical significance

P
<
0.05

. The results show that in the observation group, 92.50% of the students believed that the mixed teaching mode could arouse the enthusiasm for learning and improve the activity of the experimental class. 97.50% of the students thought that the mixed teaching mode could stimulate students’ interest in learning and improve the ability of experimental operation. 100.00% of the students thought the mixed teaching mode could be helpful in understanding the experimental. The evaluation result of the teaching mode was significantly higher than that of the control group, and the comparison result was statistically significant

P

<

0.05

. After receiving the mixed teaching mode, the observation group had a higher satisfaction with the teaching effect, with a satisfaction rate of 95.00%. The control group had low satisfaction with the teaching effect, with a satisfaction rate of 52.50%, and the difference was statistically significant

P
<
0.05

. Through the application of the mixed teaching mode combining online and offline, psychology students in higher vocational colleges can achieve better learning results and improve students’ evaluation and satisfaction of teaching effect of the mixed teaching mode of psychology experiment teaching mode in higher vocational colleges.
Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin‐Induced Diabetic Rats
Authors: Hu Yu , Wang Shu-Xiang , Wu Fu-Yu , Wu Ke-Jia , Shi Rui-Ping , Qin Li-Hong , Lu Chun-Feng , Wang Shu-Qiu , Wang Fang-Fang , Zhou Shaobo
Published: March 2022

Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This study was designed to investigate its effect and mechanism using a diabetic rat model induced by streptozotocin (50 mg/kg, i.p.). The diabetic rats were treated with GLP (300 mg/kg/day) for 10 weeks. The blood glucose, glycated hemoglobin, body weight, and the levels of blood creatinine, urea nitrogen, and urine protein were assessed. And renal pathologies were assessed by the tissue sections stained with hematoxylin‐eosin, Masson’s trichome, and periodic acid‐Schiff. The expression of phosphorylated phosphoinositide 3 kinase (p‐PI3K), phosphorylated protein kinase B (p‐Akt), and phosphorylated mammalian target of rapamycin (p‐mTOR), the autophagy proteins beclin‐1, LC3‐II, LC3‐I, and P62; the apoptosis‐related proteins caspase‐3 and caspase‐9; and the inflammation markers IL‐6, IL‐1β, and TNF‐ɑ were assessed. Results showed that GLP alleviated the impairment of renal function by reducing urinary protein excretion and the blood creatinine level and ameliorated diabetic nephropathy. The expression of p‐PI3K, p‐Akt, and p‐mTOR in the diabetic kidney were significantly reduced in the GLP treatment group compared to the without treatment group. GLP treatment activated the autophagy indicators of beclin‐1 and the ratio of LC3‐II/LC3‐I but reduced p62 and also inhibited the expression of caspase‐3, caspase‐9 and IL‐6, IL‐1β, and TNF‐ɑ. In conclusion, the effect of GLP amelioration diabetic nephropathy may be via the PI3k/Akt/mTOR signaling pathway by inhibition of the apoptosis and inflammation and activation of the autophagy process.
On the Stochastic Modeling of COVID-19 under the Environmental White Noise
Authors: Hussain Shah , Madi Elissa Nadia , Khan Hasib , Gulzar Haseena , Etemad Sina , Rezapour Shahram , Kaabar Mohammed K. A.
Published: March 2022

The COVID-19 pandemic has caused emotional loss to people around the world and provides an unusual test for public welfare, educational framework, food frameworks, and the world of work. The economic and social turmoil caused by this epidemic is increasing, and many people are at risk of falling into oppressive poverty. In this article, we describe the pandemic of infectious illness with the help of stochastic mathematical modeling. Based on the environmental white noise and by building appropriate Lyapunov functions and by applying Ito’s formula, a few subjective properties are gotten. We provide a new mathematical model for the COVID-19 spread. The novel stochastic model is used to analyze the existence and prevalence of the disease, as well as its extinction. A numerical approach is developed for computing approximate solutions of the model. We show numerical simulations of deterministic and stochastic models of COVID-19 by utilizing the MATLAB software. In this direction, three graphs are included in the paper for the numerical interpretation of the stochastic model with the help of existing parametric and initial values for the model.
A Fully Coupled Time-Domain BEM-FEM Method for the Prediction of Symmetric Hydroelastic Responses of Ships with Forward Speed
Authors: Show Tushar Kanti , Hirdaris Spyros , Datta Ranadev
Published: March 2022

This paper presents a direct time-domain method for the prediction of symmetric hydroelastic responses of ships progressing with forward speed in small amplitude waves. A transient time-domain free surface Green function is used for the idealisation of the seakeeping problem using an Earth fixed coordinate system. Free surface ship hydrodynamics are idealised in the time domain by a Green function, and forward speed effects are idealised by a space-state model. Modal actions are accounted for by Timoshenko beam structural dynamics. Flexible fluid structure interaction (FFSI) coupling is enabled by a body boundary condition, and a direct integration Newmark-

β

scheme is used to obtain symmetric dynamic responses. The method is validated against available published numerical and experimental results. A parametric study for different container ship hull forms confirms that (i) forward speed effects should be taken under consideration as far as practically possible and (ii) hull flexibility effects accounting for hull shear deformation and rotary inertia are more notable for slender hull forms.
Efficacy of Super-Mini-PCNL and Ureteroscopy in Kidney Stone Sufferers and Risk Factors of Postoperative Infection
Authors: Yuan Wenbing , Li Yingyi , Dai Yu , Luo Cheng , Zhang Hui , Xiong Haijun
Published: March 2022

To investigate the efficacy of super-mini-PCNL (SMP) and ureteroscopy in kidney stone (KS) sufferers and learn the risk factors of postoperative infection. A retrospective analysis was performed on 180 KS sufferers who were diagnosed and treated in our hospital from May 2019 to May 2021. They were enrolled into an observation group (OG, n = 104) and a control group (CG, n = 76) based on different treatment methods. Therein, the former was treated with SMP, while the latter was treated with ureteroscopy. The operation time, blood loss, hospital stay, recent stone-free rate (one week after operation), changes of serum creatinine (SCr), blood urea nitrogen (BUN), and cystatin C (CysC) levels before and after operation and complications were compared. Those sufferers were assigned to infected and uninfected groups based on their postoperative infection. The risk factors were assessed through logistic regression, and the model formula was established. The predictive value of this model for infection was tested through RO. Compared with CG, the operation time of the OG was longer, the blood loss and hospital stay were lower

P
<
0.05

, and the stone-free rate was higher

P
<
0.05

. Renal function indexes before and after treatment

P
>
0.05

and postoperative complications revealed no significant difference

P

>

0.05

. Logistic regression analysis manifested that preoperative urinary tract infection (OR: 4.690, 95% CI: 1.170–18.802), preoperative blood glucose level (OR: 11.188, 95% CI: 2.106–59.442), positive urine culture (OR: 10.931, 95% CI: 2.453–48.705), and infectious stones (OR: 3.951, 95% CI: 1.020–15.300) were independently related to infection. The risk prediction equation is

logit

p

=
−
8.913
+
1.545
×
X
1
+
2.415
×
X
2
+
2.392
×
X
3
+
1.374
×
X
4

, with a goodness-of-fit value of 0.545. The AUC is 0.930, so SMP is superior to ureteroscopy in KS sufferers. Preoperative urinary tract infection, preoperative blood glucose level, positive urine culture, and infectious stones are independently related to infection.
A Dynamic Econometric Analysis of Urbanization and Ecological Environment in Silk Road Economic Belt
Authors: Li Xing , Luo Fuzhou
Published: March 2022

On the basis of the construction of urbanization and ecology index system, this study takes the core area of Silk Road Economic Belt, Gansu, as the research object and creates the coordination evaluation model between urbanization and ecological environment in Gansu; meanwhile, it uses BP neural network to predict the coordinated development of urbanization and ecology in Gansu Province. Finally, the aforesaid model is validated by means of empirical evidence. The results show that Gansu, in the Silk Road Economic Belt, has accelerated its urbanization level in the 10-year period from 2010 to 2019 in the context of the Belt and Road Initiative, especially in Jiayuguan and Lanzhou, mainly due to its industrialization-led urbanization； meanwhile, in terms of coupling degree, most of them are between 0.45 and 0.55, and most of them are out-of-frequency pro-disorder recession type, indicating that under the background of urbanization, the ecology of each city and prefecture in Gansu is also under great pressure. At the same time, through the forecast, Gansu is considered to be in the red light in 2019, as the endangered disorder recession B environmental lagging type, indicating that Lanzhou is facing great ecological pressure, but in general, the relationship between human and land is gradually developing in harmony.
A Child with a Painful Foot: How to Get a Definitive Diagnosis
Authors: van de Kimmenade R. J. L. L. , Meijer D. T. , Hoornenborg D. , van der Vis H. M.
Published: March 2022

This case report describes an 8-year-old healthy boy with a retained wooden foreign body in his 4th metatarsal bone of his right foot. He was presented several months after the initial trauma, stepping into a toothpick, had occurred. He was operated in our hospital, and the wooden toothpick was removed. The operation and recovery were both uncomplicated. History and physical examination are essential in these types of cases with a history of penetrating trauma but can be inconclusive due to the delay in presentation. Aggressive treatment on the other hand is necessary to prevent bigger problems such as the development of inflammatory problems and persisting complaints. A thorough, systematic, and complete work-up from the history to treatment is therefore necessary and will be described in this case report.
Oxidative Stress-Related Mechanisms in SARS-CoV-2 Infections
Authors: Wieczfinska Joanna , Kleniewska Paulina , Pawliczak Rafal
Published: March 2022

The COVID-19 pandemic caused relatively high mortality in patients, especially in those with concomitant diseases (i.e., diabetes, hypertension, and chronic obstructive pulmonary disease (COPD)). In most of aforementioned comorbidities, the oxidative stress appears to be an important player in their pathogenesis. The direct cause of death in critically ill patients with COVID-19 is still far from being elucidated. Although some preliminary data suggests that the lung vasculature injury and the loss of the functioning part of pulmonary alveolar population are crucial, the precise mechanism is still unclear. On the other hand, at least two classes of medications used with some clinical benefits in COVID-19 treatment seem to have a major influence on ROS (reactive oxygen species) and RNS (reactive nitrogen species) production. However, oxidative stress is one of the important mechanisms in the antiviral immune response and innate immunity. Therefore, it would be of interest to summarize the data regarding the oxidative stress in severe COVID-19. In this review, we discuss the role of oxidative and antioxidant mechanisms in severe COVID-19 based on available studies. We also present the role of ROS and RNS in other viral infections in humans and in animal models. Although reactive oxygen and nitrogen species play an important role in the innate antiviral immune response, in some situations, they might have a deleterious effect, e.g., in some coronaviral infections. The understanding of the redox mechanisms in severe COVID-19 disease may have an impact on its treatment.
Mechanisms of Surround Suppression Effect on the Contrast Sensitivity of V1 Neurons in Cats
Authors: Yu Hao , Xu Fei , Hu Xiangmei , Tu Yanni , Zhang Qiuyu , Ye Zheng , Hua Tianmiao
Published: March 2022

Surround suppression (SS) is a phenomenon that a neuron’s response to visual stimuli within the classical receptive field (cRF) is suppressed by a concurrent stimulation in the surrounding receptive field (sRF) beyond the cRF. Studies show that SS affects neuronal response contrast sensitivity in the primary visual cortex (V1). However, the underlying mechanisms remain unclear. Here, we examined SS effect on the contrast sensitivity of cats’ V1 neurons with different preferred SFs using external noise-masked visual stimuli and perceptual template model (PTM) analysis at the system level. The contrast sensitivity was evaluated by the inverted threshold contrast of neurons in response to circular gratings of different contrasts in the cRF with or without an annular grating in the sRF. Our results showed that SS significantly reduced the contrast sensitivity of cats’ V1 neurons. The SS-induced reduction of contrast sensitivity was not correlated with SS strength but was dependent on neuron’s preferred SF, with a larger reduction for neurons with low preferred SFs than those with high preferred SFs. PTM analysis of threshold versus external noise contrast (TvC) functions indicated that SS decreased contrast sensitivity by increasing both the internal additive noise and impact of external noise for neurons with low preferred SFs, but improving only internal additive noise for neurons with high preferred SFs. Furthermore, the SS effect on the contrast-response function of low- and high-SF neurons also exhibited different mechanisms in contrast gain and response gain. Collectively, these results suggest that the mechanisms of SS effect on neuronal contrast sensitivity may depend on neuronal populations with different SFs.
Clinical Text Data Categorization and Feature Extraction Using Medical-Fissure Algorithm and Neg-Seq Algorithm
Authors: Pagad Naveen S , N Pradeep , Almuzaini Khalid K. , Maheshwari Manish , Gangodkar Durgaprasad , Shukla Piyush , Alhassan Musah
Published: March 2022

A large amount of patient information has been gathered in Electronic Health Records (EHRs) concerning their conditions. An EHR, as an unstructured text document, serves to maintain health by identifying, treating, and curing illnesses. In this research, the technical complexities in extracting the clinical text data are removed by using machine learning and natural language processing techniques, in which an unstructured clinical text data with low data quality is recognized by Halve Progression, which uses Medical-Fissure Algorithm which provides better data quality and makes diagnosis easier by using a cross-validation approach. Moreover, to enhance the accuracy in extracting and mapping clinical text data, Clinical Data Progression uses Neg-Seq Algorithm in which the redundancy in clinical text data is removed. Finally, the extracted clinical text data is stored in the cloud with a secret key to enhance security. The proposed technique improves the data quality and provides an efficient data extraction with high accuracy of 99.6%.
The Adsorption of Copper, Lead Metal Ions, and Methylene Blue Dye from Aqueous Solution by Pure and Treated Fennel Seeds
Authors: Mabungela Ntandokazi , Shooto Ntaote David , Mtunzi Fanyana , Naidoo Eliazer Bobby
Published: March 2022

This research work reports on pure and acid-treated fennel seed biomaterials for the removal of metal ions of copper Cu(II), lead Pb(II), and methylene blue (MB) dye from aqueous solution by batch adsorption. Pure fennel seeds were labelled as PFS; nitric and sulphuric acid-treated seeds were designated as NAFS and SAFS, respectively. The adsorbents were characterised by SEM, EDX, FTIR, XRD, and BET. The SEM images revealed that the surface of the adsorbents was porous. However, physicochemical characterization further revealed that BET surface area, pore size, and pore width increased for NAFS and SAFS compared to PFS. FTIR results revealed that the peaks for cellulose −COC and −OH decreased considerably for NAFS and SAFS; this indicated that cellulose was hydrolyzed during acid treatment. Adsorption data showed that all biomaterials had a higher affinity for MB dye more than Pb(II) and Cu(II) metal ions. The maximum adsorption capacities onto PFS were 6.834, 4.179, and 2.902 mg/g and onto NAFS are 15.28, 14.44, and 4.475 mg/g, while those onto SAFS are 19.81, 18.79 and 6.707 mg/g respective for MB dye, Pb(II), and Cu(II) ions. Postadsorption analysis revealed that adsorption of Pb(II) and Cu(II) was controlled mainly by the electrostatic attraction, while that of MB was synergistic of electrostatic attraction, π- π interaction, and hydrogen bond. It was found that the uptake processes of MB dye onto all adsorbents fitted Freundlich while both cations were described by Langmuir model. The thermodynamic parameters [Formula: see text] o and [Formula: see text] o indicated the endothermic nature and spontaneity of the processes, respectively.
Price Transmission Effect of Establishing FTA with African Countries from the Perspective of Trade Facilitation
Authors: Yuan Qigang , Zhai Liangliang , Xu Tongtong
Published: March 2022

The present article introduces the price transmission effect of establishing free trade areas with African countries from the perspective of trade facilitation. Studies on China-Africa economic cooperation, tariff reduction effects, trade facilitation effects, and price transmission effects in free trade areas were reviewed. The existing literature rarely incorporates tariffs, trade facilitation, and price transmission mechanisms into the research when studying the effects of free trade areas. The present article introduces trade facilitation into the research field of China-Africa cooperation. Taking the China-Mauritius free trade area as an example, the Global Trade Analysis Project model is used to study the price transmission effect after the establishment of the China-African free trade area. Create a model and motivation for other countries to establish free trade areas with African countries. The main conclusions are as follows: China-Mauritian free trade area has improved not only the terms of trade, GDP, and social welfare of the two countries, but also other African countries. This improvement effect mainly comes from the improvement of trade facilitation, and the contribution of zero tariff policy is relatively small. The domestic price changes in many industrial sectors of the two countries showed a significant increase, while the import prices generally showed a downward trend. Therefore, countries should actively participate in the process of global economic integration, and, in the negotiation of trade liberalization, both sides should adopt differentiated negotiation strategies and improve the weak aspects of trade facilitation, respectively, to achieve a win-win situation.
Does Indian Commodity Futures Markets Exhibit Price Discovery? An Empirical Analysis
Authors: Pani Upananda , Gherghina Ştefan Cristian , Mata Mário Nuno , Ferrão Joaquim António , Mata Pedro Neves
Published: March 2022

Price discovery function analyses the dynamics of futures and spot price behavior in an asset’s intertemporal dimensions. The present study examines the price discovery function of the bullion, metal, and energy commodity futures and spot prices through the Granger causality and Johansen–Juselius cointegration tests. The Granger causality test results show bidirectional causality between the spot and futures returns for gold, silver, aluminum, lead, nickel, and zinc. The Johansen cointegration test shows that spot and futures prices are in the long‐run equilibrium path for silver, aluminum, lead, nickel, zinc, crude oil, and natural gas. The vector error correction model results suggest that both the spot and futures markets are equally efficient in price discovery for the nickel. The spot market leads the futures market in price discovery for copper and zinc. However, the futures market leads the spot market in price discovery for silver, aluminum, and lead. The findings of the study suggest the market participants for implementing hedging and arbitrage strategies. It also helps the market regulators to examine the stability of these rapidly growing commodity futures markets in India.
Advanced Transition Preemption Strategy for Signalized Intersections near Highway-Rail Grade Crossings with Dual Tracks
Authors: Chen Yifeng , Rilett Laurence R. , Wu Zifeng
Published: March 2022

The current preemption method for traffic signals at intersections located near highway-rail grade crossings (IHRGC) is known as the standard preemption (SP). The SP strategy is designed to give priority to the phases which clear vehicles off the railroad tracks as quickly as possible before a train arrives at HRGCs and provides the drivers and pedestrians with a minimum warning time (MWT). However, the SP considers neither pedestrian safety nor system efficiency at IHRGCs. As a result, this may lead to safety and delay problems at IHRGCs. To solve the problems, a state-of-the-art transition preemption strategy (TPS) algorithm, named TPS_DT, is developed in this paper. The new TPS algorithm is designed for corridors with multiple HGRCs that have dual tracks. An urban highway corridor with multiple HRGCs in Lincoln, NE, was selected as the study corridor. A calibrated VISSIM model of the study corridor was used to test the safety and efficiency of the proposed algorithm. The algorithm was coded in VAP, which is an add-on module of VISSIM. A roadway-railway corridor with multiple IHRGC and dual rail tracks in Lincoln, NE, was used as the testbed. The Measurements of Effectiveness (MOEs) used for evaluation include the rate of pedestrian phase cutoffs, intersection vehicle delay, and corridor vehicle delay. It was found that TPS_DT can significantly improve pedestrian safety and reduce vehicle delay at IHRGCs. Furthermore, the effects of train arrival prediction errors on safety and efficiency of the IHRGCs are also analyzed in the paper.
Discussion on the Rise of Healthy Chinese Sports Industry and the Training Mode of Compound Sports Talents
Authors: Liu Hongbo , Li Ming
Published: March 2022

With the improvement of people's living standards and quality, sports charm stimulates people's awareness of sports consumption and makes sports industry develop rapidly into one of the important industries for the sustainable development of national economy. In modern society, sports industry has become a new industry with huge business opportunities. Especially, when the social economy develops to a certain level and sports form a certain scale, the interdependence, mutual support, and mutual promotion between sports and economy become more inseparable. This paper studies and discusses the training strategy of “compound” talents in sports industry under the background of healthy China strategy, in order to promote the development and innovation of China's sports industry. In terms of training sports talents, we should not only pay attention to personal technical, professional, practical, and understanding contents but also introduce some humanistic contents and social hot contents to improve the comprehensive quality of talents.
Abiotrophia defectiva Infective Endocarditis: A Rare and Dangerous Cause of Endocarditis
Authors: Lancaster Ian , Patel Deep , Tamboli Cyrus , Chun Patricia , Sethi Vikas , Namey Joseph
Published: March 2022

Infective endocarditis is an uncommon heart infection, typically involving heart valves. Abiotrophia defectiva is a rare cause of endocarditis, typically found within the GI tract, and is usually difficult to isolate and requires specialized media. We report a case of Abiotrophia defectiva endocarditis following a root canal.
The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis
Authors: Xu Ya-Fei , Yao Yuan , Ma Min , Yang Shu-Han , Jiang Peng , Wang Jinjun , Tsuneyama Koichi , Wang Chan , Liu Xiangdong , Li Liang , Lian Zhe-Xiong
Published: March 2022

Primary biliary cholangitis (PBC) is a cholestatic liver disease primarily featured by autoimmune-mediated damage of intrahepatic small- and medium-sized bile ducts. Elevated serum proinflammatory cytokines, serum anti-mitochondrial antibodies (AMAs), liver inflammation, and fibrosis are also hallmarks of PBC disease. However, whether the elevated proinflammatory cytokines play a role in autoimmune cholangitis remains unknown. Herein, we utilized the p40-/-IL-2Rα-/- PBC mouse model to investigate the roles of proinflammatory cytokines IL-18, IL-21, and IFN-γ in the onset and progression of PBC. IL-18-/-, IFN-γ-/-, and IL-21-/- mice were crossed with p40-/-IL-2Ra+/- mice, respectively, to produce corresponding cytokine-deficient PBC models. Autoantibody level, liver inflammation, and bile duct injury were analyzed. We found that livers from p40-/-IL-2Rα-/- mice exhibit similar transcriptomic characters of PBC patients. In p40-/-IL-2Rα-/- mice, deletion of IL-18 has no remarkable effect on disease progression, while deletion of IL-21 indicates that it is necessary for AMA production but independent of liver inflammation and cholangitis. IFN-γ is responsible for both AMA production and liver inflammation in our model. Our results demonstrate that different proinflammatory cytokines can regulate different effector functions in PBC pathogenesis and need to be considered in PBC treatment.
Real-Time Tracking Method for Sports Targets in Smart Cities under the Internet+ Background
Authors: Hu Jianping , Ye Xinjiang
Published: March 2022

Real-time tracking of video sports targets has been widely used in the sports industry. In order to further improve the accuracy of real-time tracking of sports targets, this paper proposes a real-time tracking method for sports targets in smart cities in the context of Internet+. This method collects data and information on the targets in the sports process, fully considers the diversity of the sports process, and performs real-time tracking and detection of the upgraded sports targets. Finally, the experimental research shows that the method in this paper can track the target accurately and quickly in real time during the movement process, and the accuracy and real-time tracking are relatively better than other tracking methods, which can be used as a powerful tool for subsequent moving target tracking.
Osteoblastoma and Osteoid Osteoma of the Mandible: Review of the Literature and Report of Two Cases
Authors: Ellingsen Taylor , Nalley Andrew , Oda Dolphine , Dodson Thomas B. , Lee Peggy P.
Published: March 2022

Osteoblastoma and osteoid osteoma are rare benign neoplasms of the jaws. We reviewed current literature surrounding the ongoing debate over similarities and differences of osteoblastoma and osteoid osteoma and present two cases. Both cases are well-demarcated mixed radiodensity mandibular lesions with histological features of osteoblastoma. They exhibit, however, distinctly unique and contrasting clinical and imaging characteristics suggesting that the first case is osteoblastoma and the second is osteoid osteoma. The first case of a 37-year-old male presents with a large, expansile lesion at posterior mandible, surrounded by a thick sclerotic band. Unusual features include significant buccal/lingual expansion, extensive new bone apposition, and soft tissue edema in the masseter muscle. This is in contrast to the second case of a much smaller lesion in a 17-year-old male with history of recent third molar extraction in the left posterior mandible. In this case, CT imaging revealed a circular, nonexpansile lesion with a sclerotic border surrounded by a radiolucent rim. Both patients underwent surgical excision of the lesion with extraction of the adjacent tooth. We discuss herein the distinct clinical and imaging features.
Cognitive-Behavioral Therapy (CBT) Is Applied in Post-Traumatic Stress Disorder (PTSD) of Chinese Shidu Parents Who Lost Their Only Child
Authors: Yu Guilin , Liu Hongfeng , Lenny Chiang-Hanisko , Chen Daijun , Yu Yin , Sun Chanyuan
Published: March 2022

Objective. The objective is to help Chinese Shidu parents who have lost their only child to relieve post-traumatic stress disorder. Methods. A qualitative phenomenology study using the hermeneutical phenomenological method was employed in a major metropolitan city in China. Participants were 46 parents who had lost their only child and suffered from post-traumatic stress disorder. Three major themes are: (1) to conduct semistructured in-depth interviews with 46 Shidu parents; (2) to develop and implement a psychological intervention program combining with group intervention and individual counseling based on cognitive-behavioral therapy; (3) to assess the effect of psychological intervention through PTSD Checklist for DSM-5 (PCL-5). Results. Those Shidu parents who lost their only child got great relief from PTSD. The Shidu parents got great relief and changed a lot after the intervention. They became active to participate in group counseling and willing to help others because they experienced the value and fun in the process. They rebuilt their attachment and looked forward to their future life. Conclusion. Cognitive-behavioral therapy can alleviate and even cure post-traumatic stress disorder in Shidu parents who have lost their only child.
Nonlinear Dynamic Characteristics of Multidisk Rod Fastening Rotor with Axial Unbalance Mass Distribution
Authors: Zhao Li , Zhang Haosui , Liu Yibing , Zhou Chao
Published: March 2022

During long-term operation, the blades of rod fastening rotor are very prone to fault and may cause uneven axial mass distribution. The dynamic characteristics of a multidisk rod fastening rotor with axial unbalance mass distribution are studied. A four-disk rod fastening rotor model was established by the lumped mass method. The mass unbalance on different disks was used to simulate blade faults in different parts, and nonlinear factors such as oil film force and disk contact effect were considered. The fourth-order Runge-Kutta method was used to solve the model, and the spectrum and axis trajectory curves were obtained. The influence of fault location and rotating speed on rotor dynamic characteristics was analysed when there were blade faults on two disks. The results show that a large, unbalanced mass will bring strong nonlinear characteristics. The rod fastening rotor may be in different motion states at different rotating speeds. When the fault position of two disks changes, the changes of bearing spectrum, axis trajectory, and phase difference have regularity. The results can provide a theoretical basis for condition monitoring and fault diagnosis of rod fastening rotor.
Extended Split-Step Fourier Transform Approach for Accurate Characterization of Soliton Propagation in a Lossy Optical Fiber
Authors: Farag Neveen G. A. , Eltanboly Ahmed H. , El-Azab M. S. , Obayya S. S. A.
Published: March 2022

In this paper, we present a novel extension of the well-known split-step Fourier transform (SSFT) approach for solving the one-dimensional nonlinear Schrödinger equation (NLSE), which incorporates the fiber loss term. While this essential equation governs the pulse propagation in a lossy optical fiber, it is not supported by an exact analytical solution. In this regard, extended versions of the Fourier pseudospectral method (FPSM) and Hopscotch method (HSM) are effectively established as well to cope with the fiber losses effects associated with the pulses’ propagation through the fiber optics, and thus, numerous comparisons are exhaustively conducted among these three compelling numerical approaches to validate their reliability, stability, and accuracy. Based on this, the MATLAB numerical findings bolster that the extended version of the SSFT approach demonstrates superior performance over the other suggested schemes in simulating the solitons propagation in a lossy optical fiber.
Influence of Curcumin Nanocrystals on the Early Osteogenic Differentiation and Proliferation of Dental Pulp Stem Cells
Authors: Samiei Mohammad , Arablouye Moghaddam Farzin , Dalir Abdolahinia Elaheh , Ahmadian Elham , Sharifi Simin , Maleki Dizaj Solmaz
Published: March 2022

Regenerative therapies are the developed method for regrowing, repairing, or exchanging damaged or diseased cells, tissues, or organs. Bone injury regeneration is a complicated procedure. For this reason, stimulation of the osteogenic differentiation impact on mesenchymal stem cells (MSCs) is a critical method. The goal of the current study was to test the biocompatibility and induction of early osteogenic differentiation by curcumin nanocrystals in human dental pulp stem cells (DPSCs) which are MSCs derived from dental pulp. In this study, curcumin nanocrystals were produced through the spray‐drying technique and then were characterized using conventional methods. Then, cytotoxicity and proliferative properties of curcumin nanocrystals were evaluated in different concentrations at 48 hours, 72 hours, and 7 days which were measured by the MTT test, and a special kit was used to determine the activity of alkaline phosphatase (ALP). The results of this study displayed that the prepared nanocurcumin with the mean particle size of 128 nm, spherical morphology, and the negative surface charge did not show a toxic effect on dental pulp cells in most concentrations for 48 and 72 hours and was toxic only at a concentration of 25 μM. Also, comparing the toxicity of different doses at 7 days showed that at concentrations of 2.5, 5, 10, and 25 μM, cell growth was significantly inhibited. ALP activity was increased in two weeks compared to one week and also compared to that of the control group significantly (p < 0.05). Considering the positive possessions of nanocurcumin on the osteogenic differentiation of DPSCs and its low toxicity, this substance can be considered in the planning of regenerative protocols.
Application of Deep Learning in Medical English Teaching Evaluation
Authors: Han Lu , Yao Xiaoyu , Yu Jing
Published: March 2022

Although the fact that the reform of college English teaching has yielded mixed results, medical colleges have yet to achieve a breakthrough. Deep learning (DL) is a type of education that emphasizes higher-order thinking skills. It encompasses the state of learning, the learning process, and the learning outcomes. It emphasizes critical knowledge understanding, focuses on the integration of old and new knowledge, confronts real-world problems, and pays attention to reflection. This paper establishes the EMET (evaluation of medical English teaching) model based on the improved BPNN algorithm and analyzes the performance of this model using the improved BPNN algorithm. The simulation results show that the improved BPNN algorithm proposed in this paper has fast convergence speed, strong optimization ability, and generalization ability, effectively reducing the impact of human factors on index weight determination.
FDA Approval Summary: Ivosidenib for the Treatment of Patients with Advanced Unresectable or Metastatic, Chemotherapy Refractory Cholangiocarcinoma with an IDH1 Mutation
Authors: Casak Sandra J. , Pradhan Shan , Fashoyin-Aje Lola A. , Ren Yi , Shen Yuan-Li , Xu Yuan , Chow Edwin Chiu Yuen , Xiong Ye , Zirklelbach Jeanne Fourie , Liu Jiang , Charlab Rosane , Pierce William F. , Fesenko Nataliya , Beaver Julia A. , Pazdur Richard , Kluetz Paul G. , Lemery Steven J.
Published: March 2022

On August 25, 2021, the FDA approved ivosidenib for the treatment of adult patients with unresectable locally advanced or metastatic hepatocellular isocitrate dehydrogenase 1 (IDH1) mutated cholangiocarcinoma (CCA) as detected by an FDA-approved test with disease progression after 1 to 2 prior lines of systemic therapy for advanced disease. The approval was based on data from Study AG120-C-005 (ClarIDHy), a double-blind placebo-controlled trial that randomly allocated (2:1) patients to receive either ivosidenib or placebo. Independently assessed progression-free survival (PFS) was the primary endpoint. With a median follow-up of 6.9 months, the HR for PFS was 0.37 [95% confidence interval (CI), 0.25–0.54; P < 0.0001). Overall survival (OS) was the key secondary endpoint. At the final analysis of OS, with 70.5% of patients in the placebo arm receiving ivosidenib post disease progression, a non–statistically significant improvement in the ivosidenib arm with an HR = 0.79 (95% CI, 0.56–1.12) and median OS of 10.3 months (95% CI, 7.8–12.4) and 7.5 months (95% CI, 4.8–11.1) in the ivosidenib and placebo arms, respectively, were reported. Adverse reactions occurring in >20% of patients receiving ivosidenib were fatigue/asthenia, nausea, diarrhea, abdominal pain, ascites, vomiting, cough, and decreased appetite. Adverse reactions occurring in >20% of patients receiving placebo were fatigue/asthenia, nausea, abdominal pain, and vomiting. This is the first approval for the subset of patients with CCA harboring an IDH1 mutation.