bluuebunny/crossref_metadata_2025 huggingface dataset:
Anesthesia for non-obstetric surgery during late term pregnancy in mares
Authors: Brito Pedro Henrique Salles , Ferreira Marília Alves , Rusch Elidiane , Arantes Julia de Assis , Carregaro Adriano Bonfim , Valadão Carlos Augusto Araújo , Ghantous Giovana Fumes , Dória Renata Gebara Sampaio
Published: November 2024

Submitting late-term pregnant mares to anesthesia for non-obstetric surgery raises concerns about the survival of the mother and fetus. This study aimed to evaluate and describe transient maternal and fetal hemodynamic changes during general inhalation anesthesia in mares during the last month of gestation. Nine adult mares in the last month of gestation were subjected to general inhalation anesthesia and dorsal recumbency for 90 minutes. Trans-anesthetic vital parameters, arterial hemogasometry, cardiac output, pulmonary arterial pressure, central venous pressure, and fetal heart rates were assessed at defined intervals. During various timespans of the anesthetic procedure, the mares demonstrated an increase in heart rate, mean arterial pressure, and diastolic pressure as well as a decrease in temperature. Additionally, arterial hemogasometry indicated respiratory acidosis. No changes in cardiac output were observed; however, there was a reduction in pulmonary arterial and central venous pressures and stroke volume. Fetal heart rate was significantly decreased. General inhalation anesthesia in late term pregnancy in mares in a recumbent position implies in significant hemodynamic and metabolic changes. Up to 90 minutes those changes does not seem to affect negatively the maternal-fetus prognosis.
Influence of the cautionary legend on non-nutritive sweetener (NNS) on preference and healthfulness perception
Authors: Calderon Claudia , Aburto Tania C. , Batis Carolina , Contreras-Manzano Alejandra , Barquera Simón
Published: November 2024

In 2020, Mexico’s Congress mandated front-of-package warning labels (FOPWL) and two cautionary legends; one of which for non-nutritive sweeteners (NNS) with a statement “Contains NNS. Avoid in children”. The aim of the study was to assess the influence of the “excess in sugar” warning label (WL) and NNS cautionary legend on preference and healthfulness perception of fruit-based beverages among parents of 5–10 year-olds. Also, to test if parents’ preferences and perceptions differed by nutrition knowledge and previous knowledge on NNS. Data from the EPHA niñ@s (Study of the Perception and Dietary Habits in Children, for its acronym in Spanish) cohort were analyzed (n = 844). Parents were asked to choose between 100% juice and nectar with added sugars above the cut-off point, and between the latter and nectar with NNS marketed as “light”, and to rate how healthy they considered each product at two different timepoints. At time 1, products were shown without the FOPWL; at time 2, nectar with excess sugar had the “excess sugar” WL and nectar with NNS had the cautionary legend on NNS. General Linearized Models (GLM) were used to assess changes in preference and perceived healthiness. Interaction terms assessed the impact of nutrition knowledge and NNS awareness. The study found that FOPWL significantly shifted parental preferences towards 100% juice over nectar with “excess sugar” (15.4% increase, p<0.001), and the latter over nectar with NNS (21.8% increase, p<0.001). Similarly, the FOPWL decreased the perceived healthiness of both nectar with “excess sugars” and nectar with NNS. The effect of labels on healthfulness perception was strongest among parents with low to medium nutrition knowledge and no prior knowledge of NNS. The inclusion of FOPWL seems to aid parents in making better-informed decisions regarding the nutritional quality of beverages for their children.
Fatigue and cognitive dysfunction in previously hospitalized patients with COVID-19: A 1-year follow-up
Authors: Andreasson Ingrid , Persson Hanna C. , Björkdahl Ann
Published: November 2024

Purpose

The aim was to longitudinally explore changes in fatigue- and cognition-related symptoms during the first year after hospital treatment for COVID-19.

Method

Patients hospitalized for COVID-19 in Gothenburg, Sweden, were consecutively included from 01-07-2020 to 28-02-2021. Patients were assessed at the hospital (acute) and at 3 and 12 months after hospital discharge. Cognition was assessed with the Montreal Cognitive Assessment (MoCA), the Trail Making Test B (TMTB), and the Cognitive Failure Questionnaire (CFQ). Fatigue was assessed using the Multidimensional Fatigue Inventory-20 (MFI-20) and the Mental Fatigue Scale (MFS). Data was analyzed with demographics and changes over time calculated with univariable mixed-effects models.

Result

In total, 122 participants were included. Analyzes of Z-scores for MoCA indicated improvement over the year, however the results were 1 SD below norm at all assessments. Alertness (TMTB scores) improved significantly from the acute assessment to the 12- month follow-up (p = <0.001, 95% CI 34.67–69.67). CFQ scores indicated cognitive impairment, and the sum scores for MFI reflected a relatively high degree of fatigue at follow-up.

Conclusion

In the first year after hospitalization for COVID-19, most patients experienced fatigue and cognitive impairment. Alertness improved, but improvements in other domains were limited.
Non-pharmaceutical interventions for people living with HIV with cognitive impairment: A scoping review
Authors: Stuart Lucinda , Alford Kate , Vera Jamie H.
Published: November 2024

Background

Cognitive impairment (CI) in HIV is often of multifactorial causation, and remains a prominent issue in the age of effective combination antiretroviral therapy (cART), affecting approximately 14% of people living with HIV. Despite the 2018 BHIVA directive stating the importance of commencing rehabilitation strategies in people living with HIV with CI, no types of cognitive rehabilitations or other non-pharmaceutical interventions are specifically recommended. This scoping review aimed to describe the types of and evidence relating to the non-pharmaceutical interventions which have been examined in people living with HIV with CI.

Methods

Studies were identified from five electronic databases. Criteria for study inclusion were studies describing a non-pharmaceutical intervention published after 1st January 2000 in English, in a population of adults living with HIV with CI detected at baseline, without significant psychiatric or substance-misuse co-morbidity.

Results

Fourteen studies met the criteria for inclusion, with the Frascati criteria most commonly used to define CI within participant populations. The median intervention length was 12 weeks (IQR = 6.5). Nine studies investigated interventions with some component of computerised cognitive training (CCT); other interventions included diet, exercise and goal management training. Studies most commonly examined neurocognitive outcomes, but also considered other outcomes including quality of life, depressive symptomatology, intervention acceptability and cART adherence. Eight studies observed improvement in cognition with CCT, with effects often maintained for several weeks post-intervention, however, results were not always statistically significant. Self-reported cognitive improvement and intervention acceptability was high amongst participants completing CCT.

Conclusions

There was heterogeneity across studies not only in intervention type, but in diagnostic tools used, the chosen outcome measures and cognitive batteries, making comparison difficult. Findings, however, indicate that CCT interventions may produce benefits in cognition and are acceptable to patients. Further research is required in larger samples, alongside identifying specific intervention components that improve outcomes.
Antimicrobial and antioxidant activities of peptide derived from turmeric plant (Curcuma longa L)
Authors: Roytrakul Sittiruk , Charoenlappanit Sawanya , Kittisenachai Suthathip , Siangpro Noppadon , Sichaem Jirapast , Chuakrut Songkran , Sarin Siripun , Jutakanoke Rumpa
Published: November 2024

The overuse and inappropriate use of antibiotics have led to the emergence of several antibiotic resistant bacteria. As a result, there is growing interest in exploring alternative agents as antimicrobial peptides (AMPs), which operate through unique mechanisms to effectively counteract bacterial resistance. In this study, peptides smaller than 3 kDa were isolated by cation exchange chromatography, anion exchange chromatography and reverse-phase chromatography. Subsequently, 12 candidate peptides were selected and chemically synthesized for a comparative study of growth inhibition in pathogenic bacteria. They demonstrated potent antibacterial activity toward A. baumannii, S. epidermidis, S. aureus, and S. enterica. Exposure to the Cur-1 peptide induced changes in bacterial proteins associated with metabolite interconversion and translation. In addition, all peptides derived from turmeric peptic hydrolysate exhibited antioxidant activity as assessed by ABTS, DPPH and FRAP assays. Cur-1 peptide displayed both high antibacterial and antioxidant potential, positioning it as a promising natural option for antibacterial management and applications within food industry.
Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells
Authors: Klimaj Stefan D. , LaPointe Autumn , Martinez Kimberly , Acosta Eduardo Hernandez , Kell Alison M.
Published: November 2024

Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever or cardio-pulmonary disease. With no approved therapeutics or vaccines, research has, until recently, focused on understanding the drivers of immune-mediated pathogenesis. An emerging body of work is now investigating the mechanisms that allow for asymptomatic, persistent infections of mammalian reservoir hosts with highly pathogenic RNA viruses. Despite limited experimental data, several hypotheses have arisen to explain limited or absent disease pathology in reservoir hosts. In this study, we directly tested two leading hypotheses: 1) that reservoir host cells induce a generally muted response to viral insults, and 2) that these viruses employ host-specific mechanisms of innate antiviral antagonism to limit immune activation in reservoir cells. We demonstrate that, in contrast to human endothelial cells which mount a robust antiviral and inflammatory response to pathogenic hantaviruses, primary Norway rat endothelial cells do not induce antiviral gene expression in response to infection with their endemic hantavirus, Seoul orthohantavirus (SEOV). Reservoir rat cells do, however, induce strong innate immune responses to exogenous stimulatory RNAs, type I interferon, and infection with Hantaan virus, a closely related hantavirus for which the rat is not a natural reservoir. We also find that SEOV-infected rat endothelial cells remain competent for immune activation induced by exogenous stimuli or subsequent viral infection. Importantly, these findings support an alternative model for asymptomatic persistence within hantavirus reservoir hosts: that efficient viral replication within reservoir host cells may prevent the exposure of critical motifs for cellular antiviral recognition and thus limits immune activation that would otherwise result in viral clearance and/or immune-mediated disease. Defining the mechanisms that allow for infection tolerance and persistence within reservoir hosts will reveal novel strategies for viral countermeasures against these highly pathogenic zoonotic threats.
THE IMPACT OF NEUROMUSCULAR WARM-UP ON MUSCLE CONTRACTILITY AND INJURY PREVENTION IN FEMALE SOCCER PLAYERS: ANALYSIS USING TENSIOMYOGRAPHY
Authors: Pajonková Frederika , Lenková Rút , Sučka Jaroslav , Kozel Matúš
Published: November 2024

As female soccer's popularity and participation rise, injury rates are expected to increase due to the sport's complexity, highlighting the importance of regular health and neuromuscular function screenings for injury prevention. The aim of the study was to determine how neuromuscular warm-up affects the contractility of the lower limb muscles and its significance in the prevention of injuries in female soccer players. The research sample consisted of 36 female soccer players, who were divided into an experimental (EG) and a control (CG) group with an average age 17.45 ± 2.63 years (EG) and 16.24 ± 1.09 years (CG). The contractility of the lower limb muscles was monitored using Tensiomyography (TMG). We evaluated bilaterally five muscles of the lower limbs for each soccer player: m. biceps femoris, m. gastrocnemius medialis, m. gluteus maximus, m. vastus lateralis, and m. vastus medialis. The experimental factor in the research, implemented during the warm-up phase of the training session, was neuromuscular warm-up over 12 weeks of EG. To assess the effect of the intervention program on changes in the muscle contractility of the soccer players, we employed the non-parametric Wilcoxon signed-rank test for dependent samples and the Mann-Whitney U test for independent samples. Results indicates that the speed of muscle contraction (Tc) and muscle stiffness (Dm) vary among different muscles and even between dominant and non-dominant limbs of soccer players. The impact of neuromuscular warm-up on contraction time and maximal displacement was negligible, except for a moderate effect in m. gluteus maximus of the non-dominant limb. Although the impact of neuromuscular warm-up on lower limb muscle contractility was not significant, more regular monitoring and inclusion of neuromuscular warm-up at a higher weekly frequency may have beneficial effects.
ARTERIAL BLOOD PRESSURE WAVEFORM ARTIFACTS DETECTION USING SHORT-TIME FOURIER TRANSFORM
Authors: Trukhan Valeriia , Skola Josef , Horakova Lenka , Rozanek Martin
Published: November 2024

High-frequency waveform recordings of biological signals enable more detailed data analysis and deeper physiological exploration. However, the waveform data—like invasive arterial blood pressure (ABP)—are particularly susceptible to frequent contamination with artifacts that can devalue the subsequent calculations like pressure reactivity index (PRx). This study aimed to verify the ability of the short-time Fourier transform (STFT) based algorithm to detect artifacts in the ABP waveform. Four types of modeled artifacts (rectangular, fast impulse, sawtooth and baseline drift) with different durations and amplitudes were inserted into undisturbed ABP waveforms. Short-time Fourier transform with a 5-second time window is computed on artifact-polluted ABP signals to detect changes in the frequency domain caused by these artifacts. An algorithm with three decision-making rules based on the dominant frequency component, standardized power spectrum, and the value of the second harmonic of the dominant frequency was used. Only segments that passed all three rules were labeled as artifact-free. Results indicated high sensitivity (93.35% and 94.83%) in detecting rectangular and sawtooth artifacts, with specificity exceeding 99% for both. Baseline drift artifact was detected with a low sensitivity of 5.02%, and fast impulse was not detected. This study proposes the application of a short-time Fourier transform-based algorithm to enhance the detection of clinically significant artifacts in arterial blood pressure signals, particularly relevant for PRx and other secondary calculations.
Dissonance: Cartooning in Iran, Humor, and the Study of Things That Don’t Match
Authors: Göpfert Mirco
Published: November 2024

This essay, drawing on research with cartoonists in Iran, explores cartooning as a distinctive mode of engaged knowing through drawing and humor. By unraveling the cartoonists’ capacity to perceive, compose, and amplify dissonance, the study reveals a practice that intertwines perceptive sensitivity, analytical skill, and moral commitment. Embracing dissonance through cartooning and humor not only provides new perspectives on the political present in Iran and beyond but also offers a peculiar mode of knowing the uncomfortable—studying things that don’t match. Unlike cartooning, anthropology seldom embraces humor, yet both share a capacity for navigating dissonance. Humor as an aesthetic and ethical practice can open unconventional paths for research and commitment, providing a means and audacity to understand the unknowable—all with a spirit of humility and critique.

چکیده

این مقاله با تکیه بر پژوهش با کاریکاتوریست‌های ایران، کاریکاتور را به‌عنوان شیوه‌ای متمایز از دانستن درگیرانه از طریق طراحی و طنز بررسی می‌کند. این مطالعه با آشکار کردن ظرفیت کاریکاتوریست‌ها برای درک، نوشتن و تقویت ناهماهنگی، عملکردی را نشان می‌دهد که حساسیت ادراکی، مهارت تحلیلی و تعهد اخلاقی را در هم می‌آمیزد. پذیرش ناهماهنگی از طریق کاریکاتور و طنز، نه تنها دیدگاه‌های جدیدی را در مورد وضعیت کنونی سیاسی در ایران و فراتر از آن ارائه می‌کند، بلکه شیوه‌ای عجیب از دانستن چیزهای ناراحت‌کننده-مطالعه چیزهایی که مطابقت ندارند- را نیز ارائه می‌دهد. بر خلاف کاریکاتور، انسان شناسی به ندرت از طنز استقبال می کند، با این حال هر دو ظرفیتی برای هدایت ناهماهنگی دارند. شوخ طبعی به عنوان یک عمل زیبایی شناختی و اخلاقی می تواند راه های غیر متعارفی را برای تحقیق و تعهد بگشاید و ابزار و جسارتی برای درک ناشناخته ها فراهم کند - همه با روحیه فروتنی و نقد.
One-side Liouville theorems under an exponential growth condition for Kolmogorov operators
Authors: Priola Enrico
Published: November 2024

It is known that for a possibly degenerate hypoelliptic Ornstein-Uhlenbeck (OU) operator

L
=

1

2

tr

(

Q

D

2

)

+

⟨

A
x
,
D

⟩

=

1

2

div

(

Q
D

)

+

⟨

A
x
,
D

⟩

,

x
∈

R

N

,

L=\frac{1}{2}\hspace{0.1em}\text{tr}\hspace{0.1em}\left(Q{D}^{2})+\langle Ax,D\rangle =\frac{1}{2}\hspace{0.1em}\text{div}\hspace{0.1em}\left(QD)+\langle Ax,D\rangle ,\hspace{0.33em}\hspace{0.33em}x\in {{\mathbb{R}}}^{N},

all (globally) bounded solutions of

L
u
=
0

Lu=0

on

R

N

{{\mathbb{R}}}^{N}

are constant if and only if all the eigenvalues of

A

A

have non-positive real parts (i.e.,

s

(

A

)

≤
0

s\left(A)\le 0

). We show that if

Q

Q

is positive definite and

s

(

A

)

≤
0

s\left(A)\le 0

, then any non-negative solution

v

v

of

L
v
=
0

Lv=0

on

R

N

{{\mathbb{R}}}^{N}

, which has at most an exponential growth, is indeed constant. Thus, under a non-degeneracy condition, we relax the boundedness assumption on the harmonic functions and maintain the sharp condition on the eigenvalues of

A

A

. We also prove a related one-side Liouville theorem in the case of hypoelliptic OU operators.
Guidelines for the correct use of the nomenclature of biochemical indices of bone status: a position statement of the Joint IOF Working Group and IFCC Committee on Bone Metabolism
Authors: Lombardi Giovanni , Jørgensen Niklas Rye , Harvey Nicholas C. , McCloskey Eugene V. , Åkesson Kristina E. , Eastell Richard , Garnero Patrick , Kanis John A. , Khashayar Patricia , Lane Nancy E. , McClung Michael R. , Silverman Stuart , Makris Konstantinos , Bhattoa Harjit Pal , Vasikaran Samuel D. , Pikner Richard , Cavalier Etienne
Published: November 2024

The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline proposes the nomenclature Bone Status Indices (BSI) as the comprehensive classification rather than bone turnover markers, bone markers, metabolic markers of bone turnover or metabolic markers of bone turnover, that are currently in use for the implicated molecules. On behalf of the IFCC Committee on Bone Metabolism and the Joint IOF Working Group and IFCC Committee on Bone Metabolism, the authors propose standardized nomenclature, abbreviations and measurement units for the bone status indices.
Paediatric reference intervals for haematology parameters analysed on Sysmex XN-9000: a comparison of methods in the framework of indirect sampling
Authors: Laugesen Kristina , Winther-Larsen Anne
Published: November 2024

Objectives

To provide age- and sex-specific paediatric reference intervals (RIs) for 13 haematological parameters analysed on Sysmex XN-9000 and compare different methods for estimating RIs after indirect sampling.

Methods

Via the Danish Laboratory Information System, we conducted a population-based study. We identified samples from children aged 0–18 years analysed at Aarhus University Hospital from 2019 to 2023, including samples from general practitioners only. Information about all parameters were available for all samples via linkage to the local laboratory middleware. Then, we applied two different methods. First, we excluded potential pathological samples by predefined criteria: if the child had other abnormal blood measurements at date of request, or had a blood sample of any type analysed in the period two months before to two months after. We estimated RIs stratified by age- and sex using the non-parametric percentile method. Second, we used refineR (an open source automated algorithm) to exclude pathological samples and for RI estimation. Finally, we compared our data to results from a study using the direct method.

Results

We identified 22,786 samples. After exclusion by predefined criteria, the population comprised 10,199 samples from 8,736 children (57 % of samples were from females and median age was 13 years). We estimated RIs for red blood cell, white blood cell and platelet indices. The two different methods showed agreement. Furthermore, our data provided results comparable to direct sampling.

Conclusions

Our study provided age- and sex-specific paediatric RIs for 13 haematology parameters useful for laboratories worldwide. RIs were robust using different methods in the framework of indirect sampling. Finally, our data showed agreement with the direct method, indicating that indirect sampling could be useful for establishing RIs on haematology parameters in the future.
The Semiotics of Latency: Deciphering the Invisible Patterns of the New Digital World
Authors: Leone Massimo
Published: November 2024

This paper explores the “semiotics of latency,” examining how the discipline of signs can provide insights into the increasingly invisible dimensions of contemporary communication, especially with the rise of digital technologies and artificial intelligence. The study proposes that semiotics has become more relevant today as it can reveal the latent aspects of communication, which have expanded significantly with technological advancements. The discussion spans various themes including invisibility, subtlety, infrastructure, transcendence, magic, sentience, immateriality, and minority, offering a nuanced understanding of how latent spaces – particularly in AI – shape meaning in modern contexts. By tracing historical perspectives from figures like Girolamo Cardano and Robert Hooke to contemporary phenomena like AI-generated content and its societal impacts, the paper argues for a “subtle reading” approach in semiotics. This approach bridges close reading and distant reading methods to decode the complex, often invisible infrastructures that underlie digital communication. The exploration of these hidden spaces suggests new horizons for understanding both the potential and the ethical implications of AI and digital technologies, positioning semiotics as a critical tool for navigating the unseen forces that increasingly influence our lives.
Enhancing interprofessional collaboration in digital health: Evaluation of a joint teaching program for computer science and health sciences students
Authors: Wöhlke Sabine , Schaper Manuel , Richter Moira , Lins Christian
Published: November 2024

In the digital age of health, health professionals face the major challenge of adapting to rapidly evolving digital technologies. Interprofessional collaboration (IPC) and communication are essential skills to use the potential of a digital health system and project work in Creative Labs, especially regarding high-risk projects that bring together professionals from different backgrounds for the common goal of developing innovative concepts and products. So far, too little interprofessional competence acquisition is offered at universities. In this article, we present a joint teaching program in which students of computer science and health sciences design and develop digital health projects in joint project work. The teaching program consists of different phases, including thematic basics, accompanying identification of ideas for the project work, working sessions, and final presentation of the digital health projects. We also present the teaching concept, as well as the piloting of the program and the results of its evaluation. The results point to the high potential that can unfold in IPC teaching and how important it is for future healthcare professionals to be adaptable to new technologies and IPC. Practical recommendations include considerations for joint teaching, module structure, and a brief discussion of challenges on an organizational level.
Ion channel classification through machine learning and protein language model embeddings
Authors: Ghazikhani Hamed , Butler Gregory
Published: November 2024

Ion channels are critical membrane proteins that regulate ion flux across cellular membranes, influencing numerous biological functions. The resource-intensive nature of traditional wet lab experiments for ion channel identification has led to an increasing emphasis on computational techniques. This study extends our previous work on protein language models for ion channel prediction, significantly advancing the methodology and performance. We employ a comprehensive array of machine learning algorithms, including k-Nearest Neighbors, Random Forest, Support Vector Machines, and Feed-Forward Neural Networks, alongside a novel Convolutional Neural Network (CNN) approach. These methods leverage fine-tuned embeddings from ProtBERT, ProtBERT-BFD, and MembraneBERT to differentiate ion channels from non-ion channels. Our empirical findings demonstrate that TooT-BERT-CNN-C, which combines features from ProtBERT-BFD and a CNN, substantially surpasses existing benchmarks. On our original dataset, it achieves a Matthews Correlation Coefficient (MCC) of 0.8584 and an accuracy of 98.35 %. More impressively, on a newly curated, larger dataset (DS-Cv2), it attains an MCC of 0.9492 and an ROC AUC of 0.9968 on the independent test set. These results not only highlight the power of integrating protein language models with deep learning for ion channel classification but also underscore the importance of using up-to-date, comprehensive datasets in bioinformatics tasks. Our approach represents a significant advancement in computational methods for ion channel identification, with potential implications for accelerating research in ion channel biology and aiding drug discovery efforts.
Crystal structure of diaqua-tetra((E)-(RS)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol-κ
1
N)zinc(II) dinitrate dihydrate, C60H76Cl8N14O14Zn
Authors: Li Jie , Qiu Mengying , Han Haiwei , Yan Biao , Li Hongya
Published: November 2024

C60H76Cl8N14O14Zn, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 7.758(1) Å, b = 15.376(2) Å, c = 16.518(2) Å, α = 100.946(2)°, β = 97.977(2)°, γ = 99.581(2)°, V = 1877.8(4) Å3, Z = 1, R
gt(F) = 0.0456, wR
ref(F
2) = 0.1368, T = 296(2) K.
“How come I don’t look like that”: the negative impact of wishful identification with influencers on follower Well-being
Authors: Zhang Ruonan , Mercado Trinidee , Chen Yu , Bi Nicky Chang
Published: November 2024

Purpose

Building on Social Comparison Theory and Parasocial Relationship Theory, this study is designed to investigate how followers’ wishful identification with YouTube influencers is associated with their psychological well-being and how parasocial relationships with influencers moderate this association.

Design/methodology/approach

Influencer-fan data (N = 504) is collected through a Qualtrics survey in collaboration with a real-life influencer on YouTube. Hayes Process Modeling was used to conduct mediation and moderation analyses.

Findings

Results indicate that enjoyment of influencers’ videos positively leads to followers’ wishful identification, which negatively impacts their well-being. The parasocial relationship with the influencer was found to be a significant moderator on the negative relationship between wishful identification and follower well-being in the models with vlog-oriented videos and skincare videos as independent variables.

Practical implications

This study provides guidance for influencers regarding the behaviors to lower the negative psychological impact of their videos on viewers. While influencer content creation is a thriving business, the association between influencer-following and viewer’ mental health issues should not be overlooked.

Social implications

From the viewers’ perspectives, awareness of social media comparison with influencers and the filtered effects of social media communication are also discussed.

Originality/value

As influencers continue to gain prominence on social media, their influence on followers extends beyond providing information, entertainment, companionship, and product endorsements. This study examines the negative effects of influencer content on viewers’ psychological well-being, particularly through mechanisms of social comparison and parasocial relationships.
Evaluation of the relationship between serum and humor aqueous raftlin (Rftn1) levels and diabetic retinopathy
Authors: Mesen Selma , Comez Aysegul , Mesen Ali , Beyoglu Abdullah , Seyithanoglu Muhammed
Published: November 2024

Objectives

Comparing serum and humor aqueous (HA) raftlin levels in diabetic patients and control group.

Methods

In this prospective study, patients were divided into two groups diabetes mellitus (DM) and a control group. The DM group was divided into three subgroups. A total of 160 patients, including 35 without diabetic retinopathy (non-DR) (Group 1), 31 non-proliferative diabetic retinopathy (NPDR) (Group 2), 32 proliferative diabetic retinopathy (PDR) (Group 3), and 62 controls (Group 4), were included in the study. Venous blood and HA samples were taken from the patients and their raftlin levels were measured.

Results

Serum raftlin levels were decreased in the DM main group (p=0.046) but there was no significant difference in HA raftlin levels (p=0.838). There was no significant difference between the subgroups (Groups 1, 2, 3, and 4) in terms of serum and HA raftlin levels. Diabetic macular edema (DME), anti-vascular endothelial growth factor (anti-VEGF), and panretinal photocoagulation (PRP) application were not found to be associated with raftlin levels in Group 3. A moderate positive correlation was found between serum and HA raftlin levels (r=0.491). There was a negative correlation between serum raftlin levels and serum glucose levels (p=0.05). No correlation was found between serum and HA raftlin levels and serum leukocyte and lipid levels (p>0.05).

Conclusions

In our study, raftlin levels were examined for the first time in DM patients and it was observed that serum raftlin levels were negatively correlated with glucose levels. Raftlin molecule may be involved in the etiology of DM through VEGF.
Experiências extensionistas no projeto cultural “mente, corpo e arte: o impacto da saúde no desenvolvimento criativo”
Authors: Cruvinel Agnes , Cruvinel Agnes , Tabalipa Renata , Dos Santos Betânia Francisca , Ridão Curty Gustavo Henrique , Wruck Jonatha
Published: November 2024

As habilidades comunicativas são fundamentais para a formação em saúde pautada na humanização do cuidado. Nesse sentido, a inclusão das artes no ensino da prática em saúde visa contribuir, junto à medicina narrativa, para a formação humanista e ética, apresentando como principal contribuição a oportunidade do exercício da empatia e da escuta ativa. Além disso, estudos têm demonstrado diversos benefícios da arte para o ensino em saúde, como o desenvolvimento do senso crítico e habilidades comunicativas, inerentes à boa prática profissional. Tendo em vista as mudanças promovidas pela pandemia de Covid-19, tecnologias da informação e comunicação estão sendo utilizadas para dar continuidade às atividades de extensão. Este relato expõe o processo de desenvolvimento de um projeto cultural cujo público-alvo foi composto por estudantes de diversos cursos das áreas de saúde e humanas, e cujo principal objetivo consistiu em proporcionar a esses estudantes, a partir da utilização das tecnologias de informação e comunicação remota, a reflexão a respeito das relações entre cultura, arte,  saúde e comunicação, bem como promover a inclusão às plataformas virtuais de ensino-aprendizagem, bastante difundidas no contexto de pandemia vivenciado globalmente.
Alimentação equilibrada, prática de exercício físico e higiene no Ensino Básico: a importância da abordagem lúdica
Authors: Petinari Drª Roberta Barbizan , Silva Danielle Souza , Campos Iasmin Silva , Avelar Mariana Sevirino , Barbosa Fernanda Aziz , Pinheiro MS. Náthale Rodrigues
Published: November 2024

Nas últimas décadas observou-se aumento de desordens metabólicas devido ao sedentarismo associado à ingesta de alimentos hipercalóricos e de baixo valor nutricional. Quanto mais precocemente esses hábitos prejudiciais são iniciados, mais preocupantes são as possíveis consequências. Tendo como objetivo a prevenção dessas doenças, foi trabalhada educação em saúde com crianças de 8 a 10 anos de idade, na qual foram desenvolvidas atividades lúdicas educativas abordando temas sobre a importância da atividade física; higiene pessoal; seleção de alimentos nas refeições e receitas saudáveis e economicamente acessíveis. Para mensuração de resultados, os pais ou responsáveis foram questionados sobre possíveis alterações nos hábitos das crianças. Conforme a realização das atividades propostas, pode-se observar que as crianças se tornaram mais críticas em relação ao consumo de alimentos e à higiene pessoal e ainda mais dispostas à prática de atividades físicas, além de multiplicarem esse conhecimento, levando-o a seu núcleo familiar.
Parasitoses intestinais em escolares – promoção da saúde: um relato de experiência
Authors: Fernandes Brilhante Andréia , Oliveira Braga Lucas , Alves Rocha Bruna , De Souza Ribeiro Diogo José , Gomes Pereira Júnior Noélio , Dos Santos Inácio Thiago
Published: November 2024

A taxa de prevalência das parasitoses intestinais em crianças em idade escolar é elevada, sendo mais comum em populações com baixo nível socioeconômico e higiene precária, sendo expostas constantemente a estes patógenos, o que dificulta a aplicação de medidas de controle e prevenção. As consequências das doenças parasitárias em crianças incluem o comprometimento do desenvolvimento físico e cognitivo das crianças. Nesse contexto, o projeto “Parasitoses intestinais em escolares: educar e promover saúde” foi realizado por acadêmicos de medicina da Universidade Federal do Acre, em uma escola pública de ensino fundamental localizada na cidade de Rio Branco, Acre. O projeto buscou informar a respeito da prevenção e transmissão das seguintes parasitoses: ancilostomose, larva migrans cutânea, esquistossomose, ascaridíase, enterobíase (oxiúrus), tricuríase, teníase e cisticercose. A explicação sobre os parasitas e elucidação de dúvidas ocorreu através de apresentação de banners, peças teatrais e outras atividades lúdicas. É notório a relevância da educação em saúde nas escolas, explorando a temática das parasitoses intestinais no cotidiano desde a infância, uma vez que as informações sobre a transmissão auxiliam na prevenção das doenças. Dessa forma, o projeto pretendeu difundir o conhecimento e informações acerca das parasitoses intestinais, com o objetivo de promover as medidas de prevenção e consequentemente diminuir a ocorrência dessas doenças.
A MARCA DO CAMINHAR DOS AVÓS NA RETOMADA MBYA GUARANI YJÊRE: DISPUTANDO TERRITÓRIO, HISTÓRIA E PATRIMÔNIO NA PONTA DO ARADO, PORTO ALEGRE, RS
Authors: Wittmann Marcus A. S.
Published: November 2024

Ao olhar etnograficamente para as pesquisas arqueológicas efetuadas no âmbito do licenciamento ambiental, nota-se como a definição de patrimônio cultural material está em um campo de disputa entre estado, ciências e populações tradicionais. Esse artigo pretende expor os termos dessa disputa através da análise de documentos legais e burocráticos, de relatórios técnicos de arqueologia para o licenciamento ambiental e de um estudo de caso: a retomada Mbya Guarani na Ponta do Arado (Porto Alegre, Rio Grande do Sul, Brasil). Esse panorama mostra como a ciência arqueológica pode ser constrangida por documentos burocráticos e legais, e como demandas políticas e territoriais de grupos indígenas atuam contra definições e práticas instituídas pelo estado, demonstrando suas incongruências e violências.Abstract: When looking ethnographically at the archaeological research carried out within the scope of environmental licensing, it can be seen how the definition of material cultural heritage is in a field of dispute between the state, sciences and traditional populations. This article aims to expose the terms of this dispute through the analysis of legal and bureaucratic documents, technical reports of archeology for environmental licensing and a case study: the reclaim of a Mbya Guarani territory in Ponta do Arado (Porto Alegre, Rio Grande do Sul, Brazil). This panorama shows how archaeological science can be constrained by bureaucratic and legal documents, and how political and territorial demands by indigenous groups act against definitions and practices instituted by the state, demonstrating their inconsistencies and violence.
UMA ANÁLISE SOBRE A FILOSOFIA MORAL DE ALASDAIR MACINTYRE
Authors: Osorio Victor Hugo Maia
Published: November 2024

O presente trabalho pretende analisar a importância da compreensão dos conceitos morais a partir da obra After Virtue (2007), de Alasdair MacIntyre. Será apresentada como a filosofia moral moderna encontra-se em estado grave de desordem, tendo em vista a enorme dificuldade de consenso nos debates públicos e privados cuja solução passa por arbitrariedade do defensor de cada ideia. Será exposto que alguns conceitos morais tradicionais foram deixados de lado pela modernidade, pois ela adotou um modelo focado no indivíduo despido da sua relação com o cosmo ou com a sua comunidade, bem como se perdeu a noção teleológica da natureza e do homem. Também será apresentado como MacIntyre pretende superar essa desordem pela reconstrução de uma narrativa histórica verdadeira, a partir de uma noção de ética das virtudes vinculada ao senso histórico de cada comunidade.
Two-Stage EDAS Decision Approach with Probabilistic Hesitant Fuzzy Information
Authors: Krishankumar Raghunathan , Mishra Arunodaya R. , Rani Pratibha , Ecer Fatih , Zavadskas Edmundas Kazimieras , Ravichandran Kattur Soundarapandian , Gandomi Amir H.
Published: November 2024

This paper develops a two-stage decision approach with probabilistic hesitant fuzzy data. Research challenges in earlier models are: (i) the calculation of occurrence probability; (ii) imputation of missing elements; (iii) consideration of attitude and hesitation of experts during weight calculation; (iv) capturing of interdependencies among experts during aggregation; and (v) ranking of alternatives with resemblance to human cognition. Driven by these challenges, a new group decision-making model is proposed with integrate methods for data curation and decision-making. The usefulness and superiority of the model is realized via an illustrative example of a logistic service provider selection.
Helicobacter pylori and its Role in the Pathogenesis of Diseases of the Digestive System
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Kolosovych I.V.
Published: November 2024

Helicobacter pylori is a gram-negative bacterium that is quite common among the world’s population. To date, the pathogenetic mechanisms of the bacterium’s influence on gastroduodenal ulcers and gastric cancer have been most deeply studied. However, there is a growing number of sources devoted to the association of Helicobacter pylori with the occurrence of many extra-gastric diseases. These data are quite contradictory and controversial. Given the close anatomical and functional relationship of the digestive system (digestive tract and digestive glands), it is quite natural that the bacterium Helicobacter pylori, which persists in the antrum of the stomach, has a pathological effect on this system, causing the development of a number of diseases and their complications. The purpose of this study is to analyze the current state of the problem of the role of Helicobacter pylori in the pathogenesis of diseases of the digestive system. This review presents the latest data on the pathogenetic mechanisms of gastroduodenal ulcer and gastric cancer. The persistence of the bacterium in the pancreatic-biliary system causes cholecystitis, and gallstone disease, including cholelithiasis, acute and chronic pancreatic inflammation, non-alcoholic fatty liver disease, and liver cirrhosis. Various mechanisms of carcinogenesis of tumors of the liver, gallbladder and bile ducts, and pancreas, in which Helicobacter pylori is directly involved, are highlighted. Further study of the role of the bacterium as a predictor of the development of diseases of the digestive system and their complications is promising and relevant
Method for Identification and Bacterial Count Quantification in a Case of Ureaplasma Meningitis
Authors: Uejima Yoji , Kitajima Isao , Kurita Saori , Shimizu Masaki , Niimi Hideki
Published: November 2024

Intrauterine Ureaplasma infection is associated with chorioamnionitis and preterm birth. The difficulty of detecting Ureaplasma species by conventional culture methods makes definitive diagnosis of clinical infection challenging. Thus far, quantitative tests for Ureaplasma have been performed using adult cervical samples, amniotic fluid, and pediatric bronchial secretions, but quantification of bacterial count in central nervous system infections caused by Ureaplasma species has not been unreported. We report a case of culture-negative Ureaplasma meningitis in a preterm infant in whom novel techniques to identify this pathogen and quantify bacterial count were effective. We suspected meningitis based on a sustained reduction in cerebrospinal fluid (CSF) glucose levels. Multiple CSF cultures were sterile. We confirmed infection by Ureaplasma species using the melting temperature mapping method. Treatment with erythromycin and ciprofloxacin resulted in a gradual decrease in the bacterial count in the CSF to 0. Our study highlights the potential utility of the melting temperature mapping method as a new diagnostic tool for culture-negative Ureaplasma meningitis and establishes the utility of serial quantification of bacterial count to monitor response to therapy.
Disparities in Survival Without Major Morbidity Among Very Low Birth Weight Infants in California
Authors: Liu Jessica , Profit Jochen , Hintz Susan R. , Gould Jeffrey B. , Main Elliott K. , Lee Henry C.
Published: November 2024

BACKGROUND AND OBJECTIVES

Very low birth weight infants in the NICU are more susceptible to adverse outcomes. We recently described improving survival without major morbidity among very low birth weight infants in California. This study aims to examine whether this improvement was equitable across racial and ethnic groups.

METHODS

We included 66 786 infants from the California Perinatal Quality Care Collaborative who weighed <1500 grams or were <29 weeks’ gestational age at birth and were cared for between January 1, 2008 and December 31, 2021. We examined rates of survival without major morbidity over time, stratified by safety net NICUs (snNICUs), as well as racial and ethnic groups.

RESULTS

Between 2008 and 2021, survival without major morbidity increased from 62.2% to 66.1% (P < .001), although improvement plateaued after 2017. All racial and ethnic groups saw improvement, with Native Hawaiian/Pacific Islander and Black infants improving the most (12.4% and 9.8%, respectively). However, during the last 3 years, Hispanic infants had the lowest rates of survival without major morbidity (64.3%), compared with non-Hispanic white (67.6%), Black (67.8%), Asian (68.9%), Native Hawaiian/Pacific Islander (68.5%), and American Indian/Alaskan Native (69.9%) infants. Black and Hispanic infants were disproportionately cared for in snNICUs, which experienced significantly lower survival without major morbidity than non-snNICUs at all time points.

CONCLUSIONS

We observed improvement in survival without major morbidity over 14 years, with progress stalling in recent years. Opportunities to address health inequities in NICU outcomes remain, particularly in snNICUs, while identifying strategies for continued improvement overall.
Autism, Electrical Status Epilepticus in Sleep, and a Likely Pathogenic SEMA6B Variant
Authors: Ibrahim Ahmed , Jackson David
Published: November 2024

This case report describes a boy aged 8 years with autism spectrum disorder who was diagnosed with electrical status epilepticus in sleep (ESES) and found to have a likely pathogenic variant in the SEMA6B gene. The patient presented with developmental regression and cognitive decline. An electroencephalogram demonstrated continuous spike-and-wave discharges during sleep, a hallmark of ESES. Genetic testing identified a De Novo likely pathogenic variant in SEMA6B, a gene implicated in neurodevelopmental disorders and epilepsy.

Although the association between SEMA6B mutations and ESES is not well established, this case suggests that the genetic variant may have contributed to the patient’s clinical presentation. This is the first reported instance of ESES being linked to a SEMA6B gene variant, highlighting the importance of genetic testing in similar cases. The findings could have significant implications for the understanding and management of ESES in autistic patients with behavioral difficulties. They also underscore the need for further research into the role of SEMA6B in epilepsy and neurodevelopmental disorders.
Emerging insights: Unveiling market efficiency in Mongolia's transforming economy
Authors: Jargalsaikhan Erdenechuluun , Ganbold Dagvasuren , Park Chansoo , Kim Young-Rae , Kim Junguk
Published: November 2024

The Efficient Market Hypothesis (EMH) posits that stock prices reflect all available information, preventing consistent outperformance in strong-form efficient markets. However, in inefficient markets, investors can achieve higher returns by exploiting informational advantages. This study evaluates whether the Mongolian capital market is weak-form efficient. Although the Mongolian Stock Exchange (MSE) has grown since its 1991 inception, it remains under-researched. Our analysis focuses on the MSE Top 20 Index's most frequent constituents between 2012 and 2023, assessing if their returns are independent and align with the random walk model—a characteristic of developed markets like the U.S. Using daily stock returns, we conducted statistical tests, including non-parametric (Kolmogorov-Smirnov for normality, Run test) and parametric analyses (autocorrelation under the random walk model). Results compellingly reject the random walk hypothesis, indicating weak-form inefficiency. This inefficiency implies a potential for investors to realize abnormal returns, especially through momentum-based strategies, challenging the EMH. Findings were consistent across three market cycles, enhancing robustness. Future research could apply advanced econometric models and compare results with other markets, offering deeper insights into the MSE's characteristics. This study opens new directions for strategic trading and market analysis within the Mongolian capital market.