bluuebunny/crossref_metadata_2025 huggingface dataset:
HIV-related stigma and its association with HIV transmission risk behaviors among boda boda motorcyclists in Mbarara Municipality, southwestern Uganda
Authors: Nabifo Stella C , Tsai Alexander C , Bajunirwe Francis
Published: March 2021

Background: Key populations have a disproportionate burden of HIV compared with the general population. HIV-related stigma has been recognized as a major barrier to HIV prevention and treatment efforts. It remains unclear whether HIV-related stigma is a significant driver of HIV transmission risk behavior among boda boda (motorcycle taxi) riders, a key population in Uganda. Methods: We conducted a cross-sectional study among boda boda motorcyclists in Mbarara Municipality of southwestern Uganda. Using multistage sampling, we recruited participants aged 18–59 years who had been riding for at least 6 months. The primary explanatory variable of interest was HIV-related stigma, measured using the 7-item STRIVE scale and dichotomized at “no stigma” versus “any stigma.” Self-reported HIV transmission risk behaviors included: condomless sexual intercourse, sexual intercourse under the influence of alcohol, having non-primary sexual partners, and sexual intercourse with a commercial sex worker. We used multivariable logistic regression to estimate the association between HIV-related stigma and HIV transmission risk behavior. Results: We enrolled 401 boda boda motorcyclists. All were men. Most [330 (82%)] were classified as having HIV-related stigma, particularly among younger men aged 18–29 years. One hundred and thirty-two (34%) participants reported their last sexual encounter was with a non-primary partner, 153 (39%) did not know the serostatus of their last sexual partner, and 138 (36%) reported sexual intercourse with a sex worker in the past 6 months. In multivariable logistic regression, HIV-related stigma (adjusted odds ratio [aOR] = 1.88, 95% CI: 1.06–3.34) had a statistically significant association with any HIV transmission risk behavior. Men who reported either minimal alcohol use (aOR = 1.81, 95% CI: 1.07–2.95) or harmful alcohol use (aOR = 3.5, 95% CI: 1.92–6.54), compared with men who reported no alcohol use, also reported greater odds of HIV transmission risk behavior. Conclusions: HIV transmission risk behavior is common among boda boda motorcyclists in the municipality and is associated with both HIV-related stigma and alcohol use. Interventions aimed at reducing HIV-related stigma and alcohol use may potentially reduce the high rates of HIV transmission risk behavior in this key population.
Environmental evolution and anthropogenic forcing in the Garigliano coastal plain (Italy) during the Holocene
Authors: Di Lorenzo Halinka , Aucelli Pietro , Corrado Giuseppe , De Iorio Mario , Schiattarella Marcello , Russo Ermolli Elda
Published: March 2021

The Garigliano alluvial-coastal plain, at the Latium-Campania border (Italy), witnessed a long-lasting history of human-environment interactions, as demonstrated by the rich archaeological knowledge. With the aim of reconstructing the evolution of the landscape and its interaction with human activity during the last millennia, new pollen results from the coastal sector of the Garigliano Plain were compared with the available pollen data from other nearby sites. The use of pollen data from both the coastal and marine environment allowed integrating the local vegetation dynamics within a wider regional context spanning the last 8000 years. The new pollen data presented in this study derive from the analysis of a core, drilled in the coastal sector, which intercepted the lagoon-marshy environments that occurred in the plain as a response to the Holocene transgression and subsequent coastal progradation. Three radiocarbon ages indicate that the chronology of the analyzed core interval ranges from c. 7200 to c. 2000 cal yr BP. The whole data indicate that a dense forest cover characterized the landscape all along the Prehistoric period, when a few signs of human activity are recorded in the spectra, such as cereal crops, pasture activity and fires. The main environmental changes, forced by natural processes (coastal progradation) but probably enhanced by reclamation works, started from the Graeco-Roman period and led to the reduction of swampy areas that favoured the colonisation of the outer plain.
Cryopreservation: An Overview of Principles and Cell-Specific Considerations
Authors: Whaley David , Damyar Kimia , Witek Rafal P. , Mendoza Alan , Alexander Michael , Lakey Jonathan RT
Published: March 2021

The origins of low-temperature tissue storage research date back to the late 1800s. Over half a century later, osmotic stress was revealed to be a main contributor to cell death during cryopreservation. Consequently, the addition of cryoprotective agents (CPAs) such as dimethyl sulfoxide (DMSO), glycerol (GLY), ethylene glycol (EG), or propylene glycol (PG), although toxic to cells at high concentrations, was identified as a necessary step to protect against rampant cell death during cryopreservation. In addition to osmotic stress, cooling and thawing rates were also shown to have significant influence on cell survival during low temperature storage. In general, successful low-temperature cell preservation consists of the addition of a CPA (commonly 10% DMSO), alone or in combination with additional permeating or non-permeating agents, cooling rates of approximately 1ºC/min, and storage in either liquid or vapor phase nitrogen. In addition to general considerations, cell-specific recommendations for hepatocytes, pancreatic islets, sperm, oocytes, and stem cells should be observed to maximize yields. For example, rapid cooling is associated with better cryopreservation outcomes for oocytes, pancreatic islets, and embryonic stem cells while slow cooling is recommended for cryopreservation of hepatocytes, hematopoietic stem cells, and mesenchymal stem cells. Yields can be further maximized by implementing additional pre-cryo steps such as: pre-incubation with glucose and anti-oxidants, alginate encapsulation, and selecting cells within an optimal age range and functional ability. Finally, viability and functional assays are critical steps in determining the quality of the cells post-thaw and improving the efficiency of the current cryopreservation methods.
Improving wear resistance of epoxy/SiC composite using a modified apparatus
Authors: Nassar Amal , Salem Mostafa , El-Batanony Ismail , Nassar Eman
Published: March 2021

A centrifugal mixing method was developed to disperse ceramic particles inside a thermosetting polymer. Horizontal centrifugal equipment was used to fabricate cylindrical rods from epoxy reinforced with silicon carbide particles. Silicon carbide particles (SiC) are used for the outer coating of epoxy to increase wear resistance. In the centrifugal mixing process, there are three important variables: rotational speed, ceramic percentage and, ceramic size which affect ceramic particle distribution. This paper aims to find the relationship between these variables and the distribution of ceramic particles then determine the optimum conditions to get maximum wear resistance and hardness. From the experiment and analysis, it can be concluded that when mixing speed was greater than 600 rpm, the possibility of air bubbles formation was increased especially for ultrafine particles. Otherwise, the maximum wear resistance and hardness values were found in ultrafine size SiC samples reinforced with 30 wt% which were mixed at a low speed of 300 rpm.
Crisis Within a Crisis: Migrant Workers’ Predicament During COVID-19 Lockdown and the Role of Non-profit Organizations in India
Authors: Barhate Bhagyashree , Hirudayaraj Malar , Gunasekara Noeline , Ibrahim Ghassan , Alizadeh Amin , Abadi Mehrangiz
Published: March 2021

This article explores the role of non-profit organisations in mitigating crisis for the urban working poor during the pandemic in India. We focus specifically on the humanitarian crisis around the interstate migrant workers that resulted from the Indian government’s efforts to contain the pandemic by imposing a nationwide lockdown. Through in-depth interviews with leaders of non-profit organisations in India, who were actively engaged in relief work during the migrant crisis, we explore the role of poverty and inequality in exacerbating the pandemic’s impact. Our findings indicate that multiple dimensions of inequality combined to aggravate the effects of the lockdown on interstate migrant labourers in India. The government’s initial apathy towards this vulnerable group, delay in addressing the unanticipated consequences of the pandemic response, and its ineffective crisis management efforts resulted in a humanitarian crisis in the country concurrent to the pandemic. In this context, the non-profit sector played a critical supporting role in mitigating the migrant workers’ crisis during the pandemic.
Leadership style and psychological contract
Authors: Oorschot Jane , Moscardo Gianna , Blackman Anna
Published: March 2021

This study explores the relationship between leadership style and psychological contract dimensions. The literature suggests that leaders in general and leadership style in particular can influence the psychological contracts of employees. Currently, there is no research as to how leaders perceive such contracts. This qualitative study presents the interview findings of twenty-three leaders working in public and private sector organisations. Differences were found between neutral and transformational leaders. Neutral leaders had a more transactional psychological contract, whereas the transformational leaders had a more relational psychological contract. This study adds to the literature as there is no current framework that considers the relationship between leadership styles with the psychological contract. Overall, the results indicate differences in psychological contract perceptions for different leadership styles.
Business intelligence tools to optimize the appropriateness of the diagnostic process for clinical and epidemiologic purposes in a multicenter veterinary pathology service
Authors: Pozzato Nicola , D’Este Laura , Gagliazzo Laura , Vascellari Marta , Cocchi Monia , Agnoletti Fabrizio , Bano Luca , Barberio Antonio , Dellamaria Debora , Gobbo Federica , Schiavon Eliana , Tavella Alexander , Trevisiol Karin , Viel Laura , Vio Denis , Catania Salvatore , Vicenzoni Gaddo
Published: March 2021

Laboratory tests provide essential support to the veterinary practitioner, and their use has grown exponentially. This growth is the result of several factors, such as the eradication of historical diseases, the occurrence of multifactorial diseases, and the obligation to control endemic and epidemic diseases. However, the introduction of novel techniques is counterbalanced by economic constraints, and the establishment of evidence- and consensus-based guidelines is essential to support the pathologist. Therefore, we developed standardized protocols, categorized by species, type of production, age, and syndrome at the Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), a multicenter institution for animal health and food safety. We have 72 protocols in use for livestock, poultry, and pets, categorized as, for example, “bovine enteric calf”, “rabbit respiratory”, “broiler articular”. Each protocol consists of a panel of tests, divided into ‘mandatory’ and ‘ancillary’, to be selected by the pathologist in order to reach the final diagnosis. After autopsy, the case is categorized into a specific syndrome, subsequently referred to as a syndrome-specific panel of analyses. The activity of the laboratories is monitored through a web-based dynamic reporting system developed using a business intelligence product (QlikView) connected to the laboratory information management system (IZILAB). On a daily basis, reports become available at general, laboratory, and case levels, and are updated as needed. The reporting system highlights epidemiologic variations in the field and allows verification of compliance with the protocols within the organization. The diagnostic protocols are revised annually to increase system efficiency and to address stakeholder requests.
Engagement With the Plan of Care Among Older Adults With Multiple Cardiac Diagnoses
Authors: Colorafi Karen , Evans Bronwynne , Lamb Gerri
Published: March 2021

Aging adults depend on complex treatment plans to manage chronic conditions, yet little is known about their ability to perform the sophisticated behaviors required of technologically engaged patients. This qualitative descriptive study describes engagement with the plan of care. Forty chronically ill adults participated in this study, which involved an observation of the clinical encounter and an interview. Data were collected and analyzed simultaneously in keeping with principles of qualitative research. Multiple techniques were used to test conclusions and findings were constructed as thematic sentences, including the following: I act in ways that support my health, I manage my health-related information, I make visits with my doctor part of my routine, I participate in treatment planning. Older adults work to achieve self-management to the best of their ability, shunning the use of health information technology (HIT) and demonstrating a preference for provider-created treatment plans.
Modest Association of Long-Term ACE Inhibitor Treatment With Lung Cancer: The Promise and Pitfalls of Epidemiological Drug-Safety Analyses
Authors: Fairman Kathleen A.
Published: March 2021

Results of the carefully executed Evaluation of Treatment with Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer (ERACER) study, reported in this issue, echo those of several previous observational analyses of the association of long-term angiotensin-converting enzyme (ACE) inhibitor use with incident lung cancer. These epidemiological drug-safety analyses merit cautious interpretation. First, the number needed to harm (NNH) of 6667 reported in ERACER for ACE inhibitors compared with angiotensin-2 receptor blockers (ARBs) after approximately 12 years of follow-up should be balanced against therapeutic benefits. Previously reported meta-analyses of randomized controlled trials (RCTs) over a mean 4.3-year follow-up suggested number needed to treat (NNT) of 67 for all-cause mortality, 116 for cardiovascular mortality, and 86 for a composite of myocardial infarction (MI) and stroke for ACE inhibitors, compared with nonsignificant benefits for ARBs on the mortality outcomes and NNT of 157 for ARBs on the MI/stroke composite. Second, confounding by indication is possible because until 2013, ACE inhibitors, not ARBs, were first-line medications for heart failure, which is associated with incident lung cancer. Third, findings may be compromised by detection bias due to investigation of ACE inhibitor-induced cough, or by residual confounding due to influential factors not measurable in the available data, such as socioeconomic status (SES) or smoking history. The important questions raised by ERACER and similar drug-safety analyses should be addressed in long-term RCTs or in enhanced large-database pharmacoepidemiological analyses, measuring both NNH and NNT and controlling for SES, indication, medication, and dosage.
A Taxonomy of Supports and Barriers to Family-Centered Adult Critical Care: A Qualitative Descriptive Study
Authors: Thirsk Lorraine Marie , Vandall-Walker Virginia , Rasiah Jananee , Keyko Kacey
Published: March 2021

Family-centered care (FCC) improves the quality and safety of health care provision, reduces cost, and improves patient, family, and provider satisfaction. Despite several decades of advocacy, research, and evidence, there are still challenges in uptake and adoption of FCC practices in adult critical care. The objective of this study was to understand the supports and barriers to family-centered adult critical care (FcACC). A qualitative descriptive design was used to develop a taxonomy. Interviews and focus groups were conducted with 21 participants in Alberta, Canada, from 2013 to 2014. Analysis revealed two main domains of supports and barriers to FcACC: PEOPLE and STRUCTURES. These domains were further classified into concepts and subconcepts that captured all the reported data. Many factors at individual, group, and organizational levels influenced the enactment of FcACC. These included health care provider beliefs, influence of primary versus secondary tasks, perceptions of family work, nurses’ emotional labor, and organizational culture.
Examining the Relationship Between Black Racial Identity Clusters and Postpartum Depressive Symptoms
Authors: Floyd James Kortney , Aycock Dawn M. , Barkin Jennifer L. , Hires Kimberly A.
Published: March 2021

BACKGROUND: This study examined the relationship between racial identity clusters and postpartum depressive symptoms (PPDS) in Black postpartum mothers living in Georgia. AIMS: A cross-sectional study design using Cross’s nigrescence theory as a framework was used to explore the relationship between Black racial identity and PPDS. METHOD: Black mothers were administered online questionnaires via Qualtrics. A total sample of 116 self-identified Black mothers were enrolled in the study. Participants ranged in age from 18 to 41 years ( M = 29.5 ± 5.3) and their infants were 1 to 12 months old ( M = 5.6 ± 3.5). The majority of mothers were married or cohabitating with their partner (71%), had a college degree (53%), and worked full-time (57%). RESULTS: Hierarchical cluster analysis identified six racial identity clusters within the sample: Assimilated and Miseducated, Self-Hating, Anti-White, Multiculturalist, Low Race Salience, and Conflicted. A Kruskal-Wallis H test determined there was no difference in PPDS scores between racial identity clusters. CONCLUSIONS: This study is the first to explore the relationship between Black racial identity clusters of postpartum mothers and their mental health. Findings emphasize the complexity of Black racial identity and suggest that the current assessment tools may not adequately detect PPDS in Black mothers. The implications for these findings in nursing practice and future research are discussed.
Mega-Events and Rapid Transit: Evaluating the Canada Line 10 Years After Vancouver 2010
Authors: Sroka Robert
Published: March 2021

This article examines the Canada Line rapid rail transit project in Vancouver, British Columbia, a decade after its completion and the 2010 Winter Olympic Games for which it was accelerated. The case resides at the intersection of two project classes with well-documented patterns of underperformance: transit mega-projects and sporting mega-events. Beyond connecting a number of Vancouver 2010 venues, the Canada Line is notable for its use of a public-private partnership procurement (PPP) model, as well as the significant real estate development seen nearby. In particular, the article focuses on outcomes classified under three headings: procurement model, community impact, and land use impact. Prior to providing avenues for future research, this article finds that while the PPP model avoided substantial cost overrun risks, the lucrative operational concession was where the growth coalition pushing the project was able to make it sufficiently attractive for private partners, while externalizing cost on third-parties.
Safety and tolerability of escalating cannabinoid doses in healthy cats
Authors: Kulpa Justyna E , Paulionis Lina J , Eglit Graham ML , Vaughn Dana M
Published: March 2021

Objectives

The aim of this study was to determine the safety and tolerability of escalating doses of orally delivered cannabis oils predominant in cannabidiol (CBD), tetrahydrocannabinol (THC), or both CBD and THC in healthy cats.

Methods

In this placebo-controlled, blinded study, 20 healthy adult cats were randomized to one of five treatment groups (n = 4 per group): two placebo groups (sunflower oil [SF] or medium-chain triglyceride oil [MCT]), or three plant-derived cannabinoid oil groups (CBD in MCT, THC in MCT or CBD/THC [1.5:1] in SF). Up to 11 escalating doses of each formulation were delivered orally via syringe to fasted subjects, with at least 3 days separating doses. Safety and tolerability were determined from clinical observations, complete blood counts (CBCs) and clinical chemistry. Plasma cannabinoids (CBD, THC) and metabolites (7-COOH-CBD, 11-OH-THC) were assessed.

Results

Titration to maximum doses of 30.5 mg/kg CBD (CBD oil), 41.5 mg/kg THC (THC oil) or 13.0:8.4 mg/kg CBD:THC (CBD/THC oil) was safely achieved in all subjects. All observed adverse events (AEs) were mild, transient and resolved without medical intervention. Gastrointestinal AEs were more common with formulations containing MCT. Constitutional (lethargy, hypothermia), neurologic (ataxia) and ocular (protrusion membrana nictitans) AEs were more common with oils containing THC (CBD/THC and THC oils). There were no clinically significant changes in CBC or clinical chemistry across treatment groups. Higher plasma levels of the cannabinoids and their metabolites following administration of the CBD/THC combination product are suggestive of a pharmacokinetic interaction.

Conclusions and relevance

This is the first feline study to explore the safety and tolerability of CBD and THC, alone and in combination, in a controlled research setting. These findings will inform veterinarians of the safety profile of cannabinoids, particularly when considering the potential therapeutic use of CBD in cats or recognizing clinical signs associated with accidental exposure to THC-containing products.
Tarsoconjunctival ‘Hughes’ flap for repair of globe perforation: A modified technique in the management of severe scleral necrosis
Authors: Hughes Laura , Saxby Ed , Wright Mark
Published: March 2021

We report an unusual case of scleral and lid necrosis from suspected self-harm and the management of the resultant scleral perforation with a tarsoconjunctival ‘Hughes’ flap. To our knowledge, no previous literature describes such a technique in the repair of toxic scleral melts. Our case describes an alternative use for a Hughes flap in providing tectonic support and helping to restore the integrity of the globe in a complex case where conventional methods of ‘patching’ had failed.
Indigenous peoples’ experiences and preferences in aged residential care: a systematic review
Authors: Keelan Karen , Pitama Suzanne , Wilkinson Tim , Lacey Cameron
Published: March 2021

Although the demand for aged residential care increases, low use of aged residential care by Indigenous people raises questions about unrecognised barriers to health care. The objectives of this systematic literature review are to (a) examine current scientific literature that reports older Indigenous people’s experiences in aged residential care and (b) describe critical factors that shape Indigenous people’s preferences in aged residential care settings. We conducted a systematic review of studies using an online search of the literature. A total of 6,233 citations were retrieved, and 45 studies examined in full-text. Eight studies met the study inclusion criteria. Indigenous older people were found to be younger, had higher prevalence of complex health conditions, and were less likely to receive dental and mental health services on admission to aged residential care. Their preferences for care were more likely to be evident in aged residential care facilities where the Indigenous composition of staff reflected the Indigenous makeup of its residents.
Investigation of the tribological performance of reciprocating seals in a wide temperature range
Authors: Peng Chao , Ouyang Xiaoping , Schmitz Katharina , Wang Wei , Guo Shengrong , Yang Huayong
Published: March 2021

Reciprocating seals are widely used in general industrial machines and are designed to endure rigorous working conditions. Among the harshest challenges, the wide temperature range they withstand has a significant influence on their sealing performance. However, most studies of reciprocating seals have focused only on their sealing characteristics at normal temperatures. To investigate the impacts of temperature on the seal's tribological performance, this paper examines the VL seal, a kind of combined seals, and discusses its performance in a wide temperature range. Material properties of the VL seal at temperatures from −55 °C to 135 °C are measured based on the seal product. The thermo-viscosity effect and the influence of thermal expansion and contraction are both considered in the reciprocating seal modelling. A coupling method that combines the finite-element analysis model with a mixed-lubrication procedure is implemented. For deformation calculation, a comparison between the influence coefficient method and the semi-infinite space method is conducted, and finds only minuscule disparities for the VL-seal analysis. To avoid the divergent problem due to high viscosity at low temperatures, this paper proposes the successive approaching method. Details of the sealing zone in the outstroke and instroke are systematically discussed in relation to a wide range of temperatures. The corresponding experiments are conducted and compared with the simulation. The results indicate that the temperature has a tremendous influence on the tribological performance. The leakage and the friction at the high temperature are much higher than those at the normal temperature.
Investigation of adhesive wear properties of glass fiber reinforced polyester composites having different chemical compositions
Authors: İlhan Recep , Feyzullahoğlu Erol
Published: March 2021

Glass fiber reinforced polyester composite materials are widely used in various areas due to their high specific strength, low weight, excellent elasticity, high corrosion resistance, and high thermal stability. This study aims to investigate the effects of resin materials and various fillers and wear parameters such as different loads and speeds on the tribological properties of glass fiber reinforced polyester composite materials. In this experimental study, various resins (tensile additive orthophthalic polyester and plain orthophthalic polyester), fillers (alumina and glass beads), and reinforcing materials were used during the sample preparation. The samples were subjected to an adhesive wear test at two different speeds ( n = 100 r/min and n = 200 r/min) and different loads ( F = 10 N and F = 20 N) at 150 m sliding distance. The friction coefficient and friction force were measured by the tribometer. The thickness of the wear trace was later measured and the wear rate was calculated. Wear surfaces of samples were visualized with a three-dimensional laser profilometer in order to obtain surface topographies and surface roughness values. The sample surfaces were examined by scanning electron microscopy in order to understand the wear mechanisms and to characterize the morphology of worn surfaces. Experimental results have shown that alumina or glass beads fillers can reduce the average friction coefficient when used in the correct amounts. The use of glass bead filler in orthophthalic polyester resin with tensile additive is more effective than reducing the wear rate compared to alumina filler. The load on the wear behavior of glass fiber reinforced polyester composite materials is more effective than the speed.
Self-rated health and multimorbidity in patients with type 2 diabetes
Authors: Umeh Kanayo
Published: March 2021

The relationship between multimorbidity and self-rated health is well established. This study examined self-rated health in relation to multimorbidity, glycaemia and body weight specifically in adults with type 2 diabetes. Bootstrapped hierarchical logistic regression and structural equation modelling (SEM) were used to analyse survey data from 280 adults with type 2 diabetes. The odds of ‘fair/bad/very bad’ self-rated health increased 10-fold in patients with three (OR = 10.11 (3.36–30.40)) and four conditions (OR = 10.58 (2.9–38.25)), irrespective of glycaemic control ( p < 0.001). The relationship between multimorbidity and perceived health was more pronounced in male patients. SEM generated a model with good fit, χ2 (CMIN) = 5.10, df = 3, p = 0.164, χ2 (CMIN)/df = 1.70, RMSEA = 0.05, CFI = 0.97, TLI = 0.95 and NFI = 0.94; self-rated health mediated relations between multimorbidity and BMI. Overall, this study highlights the potential of self-rated health to mediate relationships between multimorbidity and BMI, but not glycaemic control, in adults with type 2 diabetes.
Learning new verbs with known cue words: The relative effects of noun and adverb cues
Authors: Kasahara Kiwamu , Yanagisawa Akifumi
Published: March 2021

Research has shown that learning a known-and-unknown word combination leads to greater learning than learning an unknown word alone (Kasahara, 2010, 2011). These studies found that attaching a known adjective to an unknown noun can help learners remember the unknown noun. Kasahara (2015) found that a known verb can serve as an effective cue to remember an unknown noun in a known-and-unknown combination. To examine useful cues to learn unknown verbs, this study compared verb (unknown) + noun (known) combinations to verb (unknown) + adverb (known) combinations. Additionally, we explored how learners’ vocabulary size would affect the known-and-unknown two-word combination learning to deepen our understanding of the characteristics of students who benefit from combination learning. The participants in each group learned 18 two-word combinations consisting of the same unknown target verbs and different known cues (nouns or adverbs). The participants were provided with a five-minute learning phase and two immediate recall tests: a Single Word Test, to write down the L1 meanings of the targets, and a Combination Test, to write down the L1 meanings of the combinations. The same two tests were administered one week later. The results showed that known nouns were better cues for learning unknown verbs than known adverbs. It was also found that participants with a larger vocabulary size benefited more from two-word combination learning.
What makes a place special? Research on the locality of cities in the Yellow River and Rhine River Basins based on Street View Images
Authors: Wang Fang , Yuan Congcong , Li Jianing , Liu Binyi
Published: March 2021

Globalization and urbanization have caused unprecedented impacts in local identification and cultural protection, and rivers that cross administrative boundaries have attracted attention in the protection of local cultural heritage, resource integration and mobilization. This study selected several cities in the Yellow River Basin and the Rhine River Basin as examples, using street view images, combining locality theory with computer vision analysis methods, and proposing a framework for quantitative research on locality expression. Then the generation mechanism of the local characteristics was discussed. The results show that the cities in the two countries show significant differences, whereas some cities in the basin are similar. The images of the ‘Built Environment' and ‘Social Life' are more conducive to identifying the cities. The construction qualities of ‘Remains' and ‘Water' are the key built environmental factors for the coexistence of locality differences and similarities. The protection of historic buildings and less manual intervention in the water environment are of great significance to the local shaping of German cities and have reference value for developing Chinese cities. The research responds to the homogenization of the urban landscape, the symbiotic relationship between cities and water, and sustainable development in river basin cities.
A study of smile aesthetic perception among dental professionals, patients and parents towards impacted maxillary canine treatment options
Authors: Seager Leonie , Shah Jinesh , Burke Trevor , Khambay Balvinder
Published: March 2021

Objective:

To evaluate the smile aesthetics of the different treatment options for impacted maxillary canines as perceived by orthodontists, dentists, patients and parents.

Design:

Cross-sectional survey.

Setting:

Four rater groups were selected to complete the questionnaire consisting of an orthodontist group, a general dental practitioner group, a patient group consisting of patients aged 11–18 years who were considered to be ‘Gillick competent’ and a parent group consisting of parents/guardians who accompanied the patients to their orthodontic appointments.

Method:

Four digitally manipulated images were created to imitate different treatment options available for the treatment of ectopic maxillary canines including: alignment of the impacted maxillary canine; substituted premolars; retained deciduous canines; or gaps present. The images were embedded into piloted questionnaires. Each participant completing the questionnaire was asked to mark the visual analogue scale (VAS) beneath each image according to their perception of attractiveness of each image. Quantitative scoring of the perceived attractiveness of the smile was assessed by one calibrated assessor measuring the distance from the start of the scale to the marked cross placed on the VAS. A two-way ANOVA (mixed between-within subject’s ANOVA) was used to compare perception of differences in smile aesthetics.

Results:

There were significant differences found in the VAS between the groups ( P = 0.002) and between the treatment options ( P < 0.001) There was no statistically significant difference found between the aligned canines and substituted premolars images by the patient ( P = 0.2) or parent group ( P = 0.5). All groups most disliked the treatment option where gaps were present at the end of treatment.

Conclusion:

The patient and parent groups showed similar perception in smile aesthetics for aligned canines and substituted premolars and all groups showed a strong dislike to the presence of gaps. The orthodontist group showed the most critical aesthetic perceptions.
The use of Twitter by people with young-onset dementia: A qualitative analysis of narratives and identity formation in the age of social media
Authors: Talbot Catherine V , O’Dwyer Siobhan T , Clare Linda , Heaton Janet
Published: March 2021

A diagnosis of dementia in midlife can be challenging, causing losses or changes in a person’s identity. Narrative provides a means of reconstructing identity and can be communicated on social media. There has been initial evidence on the value of Twitter for people with dementia, but researchers have not yet directly engaged with users’ perspectives. We employed a narrative model of identity to examine why people with dementia use Twitter and what challenges they face. Interviews were conducted with 11 younger people with dementia and analysed thematically. Participants used Twitter to counter a loss of identity through community membership and by regaining a sense of purpose. They sought to redefine dementia identities by challenging stigma and campaigning for social change. The character limit of tweets facilitated narrative through which participants preserved their identities. These findings suggest that Twitter could be an important source of post-diagnostic support for people with young-onset dementia. However, there are some risks as Twitter was sometimes a hostile environment for individuals who did not present in a ‘typical’ manner, or faced technical difficulties because of their symptoms. In the future, platform developers could work with people with dementia to make Twitter more accessible for this group.
Fénelon and the refinement of self-love
Authors: Turner Brandon
Published: March 2021

Drawing on his past work as an interpreter of Adam Smith, Hanley offers an account of Fénelon’s social and political thought that emphasizes the role (and the dangers) of pride and self-love in human affairs. Fénelon does not join those, like Mandeville and La Rochefoucauld, who seek to understand and possibly to control self-love. Instead, he attempts to wed a far more rigorous and classical approach to the problem of pride—namely, the refinement of self-love through virtuous practices—to a modern view of the state and political economy.
Global–local model for three-dimensional guided wave scattering with application to rail flaw detection
Authors: Spada Antonino , Capriotti Margherita , Lanza di Scalea Francesco
Published: March 2021

This study presents a three-dimensional global–local formulation for the prediction of guided wave scattering from discontinuities (e.g. defects). The approach chosen utilizes the Semi-Analytical Finite Element method for the “global” portion of the waveguide, and a full Finite Element discretization for the “local” portion of the waveguide containing the discontinuity. The application of interest is the study of guided wave scattering from transverse head defects in rails. Theoretical scattering results are impossible to obtain in this case for a wide-frequency range. While three-dimensional Semi-Analytical Finite Element–Finite Element models for guided wave scattering studies have been used in the past, this is the only study where guided waves in rails were modeled in a wide-frequency range (up to 180 kHz). A comparison analysis with a benchmark study of wave reflections from the free end of a cylindrical rod is conducted first. For the case of the rail, selected case studies of incoming guided modes were chosen, and reflection and transmission spectra are calculated for head defects of various sizes. This kind of results can be utilized to guide and/or interpret ultrasonic guided wave tests aimed at defect detection or quantification. Finally, parametric studies are conducted to examine more closely the role of certain operational parameters that are important in this kind of analysis, and specifically the size of the “local” region and the number of guided modes considered. These parametric studies lead to compromises that need to be struck on the basis of conservation of energy among all wave modes involved.
Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method
Authors: Funakoshi Haruki , Momo Kenji , Kashima Ayaka , Ida Hitomi , Miyata Yoshito , Sagara Hironori , Sasaki Tadanori
Published: March 2021

Introduction:

Traditional Chinese medicine (TCM) is a traditional treatment based on herbal medicines and holistic healing. It has resulted in both favorable and unfavorable patient outcomes when used to treat cancer. Cancer patients frequently depend on second opinions and folk remedies. In this case, we report the case of TCM inducing repeated moderate liver injury and delay for chemotherapy.

Case presentation:

A 59-year-old woman was diagnosed with lung cancer and conducted surgery a month ago. She went to a TCM specialty clinic expecting a complete cure for the lung cancer, to improve her physical condition, and to enhance her immunity. She received the TCM formulas hanshirento, zenshikunshito, and ninjin’yoeito. After starting these medicines, she felt severe fatigue but continued them for approximately 2 weeks, After discontinuing the medicine, her fatigue was improved. She was admitted to our hospital for adjuvant chemotherapy. On admission, laboratory tests revealed moderate liver injury (AST: 705 U/L, ALT: 1091 U/L). In view of her medication history, the laboratory tests, and her lifestyle history, we thought that moderate liver injury was caused by TCM, employing the Roussel Uclaf Causality Assessment Method (RUCAM).

Discussion:

TCM are known to be metabolized by the resident bacteria in the small intestine, but the specific metabolic processes are not well understood. Cancer patients sometimes try TCM from their own research to stay healthy. However, as with our case, TCM rarely induces liver injury, which is not well known to TCM users. Medical staffs need to be vigilant with their drug histories, including TCM, if patients have liver injuries.
Behavioral and Neurophysiological Markers of ADHD in Children, Adolescents, and Adults: A Large-Scale Clinical Study
Authors: Münger Marionna , Candrian Gian , Kasper Johannes , Abdel-Rehim Hossam , Eich Dominique , Müller Andreas , Jäncke Lutz
Published: March 2021

This study aimed to re-evaluate the possible differences between attention-deficit/hyperactivity disorder (ADHD) subjects and healthy controls in the context of a standard Go/NoGo task (visual continuous performance test [VCPT]), frequently used to measure executive functions. In contrast to many previous studies, our sample comprises children, adolescents, and adults. We analyzed data from 447 ADHD patients and 227 healthy controls. By applying multivariate linear regression analyses, we controlled the group differences between ADHD patients and controls for age and sex. As dependent variables we used behavioral (number of omission and commission errors, reaction time, and reaction time variability) and neurophysiological measures (event-related potentials [ERPs]). In summary, we successfully replicated the deviations of ADHD subjects from healthy controls. The differences are small to moderate when expressed as effect size measures (number of omission errors: d = 0.60, reaction time variability: d = 0.56, contingent negative variation (CNV) and P3 amplitudes: −0.35 <  d < −0.47, ERP latencies: 0.21 <  d < 0.29). Further analyses revealed no substantial differences between ADHD subtypes (combined, inattentive, and hyperactive/impulsive presentation), subgroups according to high- and low-symptomatic burden or methylphenidate intake for their daily routine. We successfully replicated known differences between ADHD subjects and controls for the behavioral and neurophysiological variables. However, the small-to-moderate effect sizes limit their utility as biomarkers in the diagnostic procedure. The incongruence of self-reported symptomatic burden and clinical diagnosis emphasizes the challenges of the present clinical diagnosis with low reliability, which partially accounts for the low degree of discrimination between ADHD subjects and controls.
Vulnerability, Agency, and the Research Encounter: Family Members' Experiences and Perceptions of Participating in an Observational Clinical Study in Kenya
Authors: Zakayo Scholastica M. , Kimani Mary N. , Sanga Gladys , Njeru Rita , Charo Anderson , Berkley James A. , Walson Judd L. , Kelley Maureen , Marsh Vicki , Molyneux Sassy
Published: March 2021

Pediatric clinical research in low-resourced countries involves individuals defined as “vulnerable” in research ethics guidance. Insights from research participants can strengthen the design and oversight of studies. We share family members' perspectives and experiences of an observational clinical study conducted in one Kenyan hospital as part of an integrated empirical ethics study. Employing qualitative methods, we explored how research encounters featured in family members' care-seeking journeys. Our data reveals that children's vulnerability is intricately interwoven with that of their families, and that research processes and procedures can inadvertently add to hidden burdens for families. In research, the potential for layered and intersecting situational and structural vulnerability should be considered, and participants' agency in constrained research contexts actively recognized and protected.
Are Women Opting Out? A Mixed Methods Study of Women Patrol Officers’ Promotional Aspirations
Authors: Todak Natalie , Leban Lindsay , Hixon Benjamin
Published: March 2021

Using national survey and interview data from women patrol officers in the United States, we assess whether women are underrepresented in the upper ranks of policing because they are self-selecting out of promotions. With only 42% of the survey sample reporting a desire to promote, we indeed find evidence that many policewomen are either delaying or forgoing promotions. Among those who were eligible for promotion, the most common reasons given for waiting to promote were the desire to keep one’s current shift and to gain more experience. Based on our findings, we offer recommendations for reducing gendered barriers to promotion and increasing gender diversity in the upper ranks of law enforcement.
Remembering the bad ones: Does the source memory advantage for cheaters influence our later actions positively?
Authors: Kroneisen Meike , Bott Franziska M , Mayer Maren
Published: March 2021

Previous research has demonstrated that people remember information that is (emotionally) incongruent to their expectations, but it has left open the question if this memory enhancement has also an influence on our later actions. We investigated this question in one pilot study and two experiments. In all studies, participants first interacted with trustworthy and untrustworthy looking partners in an investment game. Facial trustworthiness was manipulated to stimulate social expectations about the behaviour of the partners. In a later second investment game, participants played against old opponents from the first game and new opponents. Overall, willingness to cooperate in the second game was influenced by the formerly behaviour of the opponent. However, facial trustworthiness affected economic decisions, too. Furthermore, we analysed source memory data that indicated no differences in memory between cheaters and cooperators. Instead, source guessing was related to cooperation: The more participants guessed that an untrustworthy looking face belonged to a cheater, the less they cooperated with untrustworthy looking opponents. Interestingly, in Experiment 2, we found a positive correlation between old-new recognition and later cooperation. In sum, the results demonstrate that memory and guessing processes can influence later decisions. However, economic decisions are also heavily affected by other social expectations like facial trustworthiness.
Hand function 5 years after treatment with collagenase Clostridium histolyticum injection for Dupuytren’s disease
Authors: Göransson Ingrid , Brudin Lars , Irbe Andra , Turesson Christina
Published: March 2021

The aim of this study was to report hand function, disability and satisfaction and patients’ perception of functionally troublesome contractures 5 years after injection with collagenase Clostridium histolyticum and hand therapy for Dupuytren's disease. Data from 79 patients were collected before and at 3, 12 and 60 months after treatment. Hand function was significantly improved, and 70% achieved a functional range of motion in the treated hand. QuickDASH scores and range of motion were best at 3 months follow-up. At 60 months, mean total extension deficit was 48°, which was 57% of the deficit before treatment. Thirty-seven patients (47%) had developed recurrent contractures in treated finger(s) meeting the criteria for new treatment. The threshold for functionally troublesome contractures was found to be 30°–60° in the finger joints. Treatment was experienced as painful, but few hand function problems occurred. Most patients would choose this treatment method again.

Level of evidence: IV
Comparative assessment of fingertip replantation in paediatric and adult patients within a single institution
Authors: Özdemir Fethiye Damla Menkü , Uzun Hakan , Özdemir Erdi , Aksu Ali Emre
Published: March 2021

The purpose of this retrospective study was to compare the outcomes of paediatric and adult fingertip replantation within a single institution. Our retrospective study found no significant difference in the survival rate between the paediatric (10/12) and adult (22/26) groups. At 6 months follow-up, there was no significant difference in sensory recovery between both groups, as measured with Semmes–Weinstein testing, but a significant difference in mean static two-point discrimination testing values between the paediatric (4.0 mm) and adult (6.2 mm) groups. Moreover, the mean time for regaining sensation was faster in paediatric patients (1.3 months) as compared with adult patients (4.1 months). Five children and four adults received erythrocyte transfusion. Paediatric fingertip replantation has similar survival rates, faster and better sensory nerve recovery as compared with adults despite a higher erythrocyte transfusion rate. Although technically demanding, paediatric fingertip replantation is recommended, whenever possible, because of the good outcomes achievable.

Level of evidence: IV