bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of metastatic breast carcinoma cells in a bone marrow sample by flow cytometry: case report
Authors: Vieira Daniella Serafin Couto , Reis Manoela Lira , Wopereis Sandro , Silva Maria Claudia Santos Da
Published: January 2021

Introduction: Breast cancer is a global public health issue due to its high mortality. Despite the multidisciplinary approaches and strategies to reduce mortality, many women are diagnosed in advanced stages with metastases, compromising the chances of cure. Objective: To report the case of a 28-year-old woman, G3, with a history of postpartum depression, on treatment for post-breastfeeding mastitis, with lumbar pain radiating to the chest and lower limbs for 5 months, progressing to epistaxis, hair loss, lymphadenopathy, dyspnea, lower limb petechiae, weight loss of 20 kg, and bicytopenia in the prior 2 months. She was admitted to the emergency department with fever and night sweats and was diagnosed with metastatic breast cancer based on bone marrow (BM) analysis by flow cytometry (FC). Method: BM biopsy (BMB) was performed and evaluated by FC immunophenotyping using the antibodies anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD56, anti-CD34, anti-CD45, and anti-HER2. The streptavidin-biotin-peroxidase method was adopted for the phenotypic evaluation by immunohistochemistry (IHC). Results: Clinical findings and her history favored the hypothesis of lymphoproliferative neoplasm. BM samples were collected for immunophenotyping and BMB for histological study and IHC. The initial aspirate analysis by FC identified 0.90% of non-hematological cells, with a positive expression for the antibody anti-HER2, suggesting epithelial neoplasm, which directed the investigation toward solid tumor with unknown primary site. The presence of this cellular component guided the IHC panel of BMB. Cells positive for CKPOOL, CK7, E-cadherin, estrogen receptor, progesterone receptor, HER2, GCDFP15, and mammaglobin were identified, indicating immunophenotype of metastatic breast disease in the BM. Later, a nodule was clinically detected in the right breast, showing a pattern consistent with that found in the BM sample, confirming the metastatic breast carcinoma. Conclusions: FC has proven to be a methodology of great clinical importance. Its routine laboratory application in the diagnosis of solid tumors could become a useful tool, providing agility and increasing diagnostic coverage.
Metastasis of neuroendocrine tumor mimicking primary breast cancer: case report
Authors: Vieira Yuki Tany Hirakawa , Perina Andre Luiz de Freitas , Vendramini Daniela Ferreira Vieira , Gallo Thatyanne Cunha Esposito , Andrade Felipe Eduardo Martins
Published: January 2021

Introduction: Neuroendocrine tumor has an annual incidence of 2–5 cases/100,000 inhabitants, most of them asymptomatic, and may clinically present as carcinoid syndrome: facial flushing, diarrhea, and bronchospasm. It has a great tendency to metastasize to regional lymph nodes and liver, being unusual in the breast. Clinical case: A black 47-year-old woman without comorbidities presented a nodule with progressive growth for 2 years in the right upper inner quadrant (RUIQ), biopsied and diagnosed as breast cancer, without a specific subtype or immunohistochemistry (IHC). Physical examination revealed a 3 cm nodule, hard and fixed axillary lymph node, and enlarged yet fibroelastic and mobile anterior cervical lymph node. Ultrasound (US) identified two irregular nodules in the RUIQ and the junction of the right outer quadrants (JROQ) measuring 2.5 cm and 0.7 cm, respectively, and level I axillary lymph node with cortical thickening. The JROQ nodule and the axillary lymph node were biopsied. The cervical lymph node did not show loss of hilum or suspicious abnormalities on US and was not biopsied. Anatomopathological results of the nodule were compatible with invasive carcinoma without a specific subtype, with estrogen receptor weakly positive (10%), Ki-67 7%, and negative for other markers. The axillary lymph node was negative for metastasis. During staging, an abdominal computed tomography identified a 1.9 cm lesion of likely neuroendocrine origin in the ileocecal valve with metastasis to the liver, regional lymph nodes, and breast. Complementary IHC of the biopsy slide was later performed with chromogranin, synaptophysin, and CDX-2, and the diagnosis reached was breast metastasis of neuroendocrine tumor. An external review of biopsy slides of the RUIQ nodule was requested, and the patient was referred to the oncology department to continue treatment. Conclusion: Metastasis of gastrointestinal tumors to the breast corresponds to less than 0.5% of cancers, with 15 reports in the literature, of which only 7 were asymptomatic, and their clinical presentation started with breast lesion, as in the case described herein. Given its rarity, as well as the clinical and radiological difficulties in differentiating these lesions, special attention must be paid to differential diagnoses, especially in cases of discrepancies between the tumor histology and IHC or lack of correlation between image and clinical condition.
Analysis of two groups of young patients with breast cancer
Authors: Solino Matheus de Paula , Cardoso Mariana Soares , Antonini Marcelo
Published: January 2021

Introduction: Breast cancer is the main type of cancer and the main cause of death by cancer among women worldwide. For Brazil, the National Cancer Institute José Alencar Gomes da Silva (Instituto Nacional de Câncer José Alencar Gomes da Silva – INCA) estimated that breast cancer would be responsible for 29.5% of new cancer cases and 16.2% of cancer deaths in 2019. The incidence of breast cancer in young women has grown worldwide: in developing countries, 25% of breast cancer cases occur in women under 40 years of age. In young women, breast cancer has more aggressive characteristics and is diagnosed later. Mammography is the best screening method, however, it is only started at 40. Objective: To analyze the clinical, pathological, and treatment characteristics among patients with breast cancer diagnosed up to 40 years old and between 41 and 45 years old. Methods: Observational and cross-sectional study, which evaluated patients diagnosed with breast cancer until the age of 45 and who underwent surgical treatment at the Hospital do Servidor Público Estadual between October, 2013 and October, 2017. Data were collected from medical records and patients were divided into two groups: Group 01, up to 40 years old and Group 02, from 41 to 45 years old. Variables were collected regarding age at diagnosis, menarche, number of deliveries, body mass index (BMI), comorbidities, family history of breast cancer, initial clinical staging, type of biopsy, type of histological biopsy result, type of treatment, and surgical results. The variables were analyzed statistically. Results: Fifty patients aged between 29 and 45 years old were evaluated. There was no statistically significant difference in clinical characteristics. Group 02 presented more tumors with hormonal receptors, more cases of axillary emptying after compromised sentinel lymph node, and lower rates of radiotherapy. Conclusion: Young patients aged 41-45 years old present more tumors with hormonal receptors, greater involvement of microscopically locoregional lymph nodes, and less treatment with radiotherapy than young patients under 40 years of age.
Epidemiological profile of aged women with breast cancer in a private clinic in Criciúma/sc
Authors: Peters Maristela Harder , Klering Giorgia Emilia , Bonfante Thamyra Manenti
Published: January 2021

Objectives: Breast cancer is the most common cancer among women, gradually increasing its incidence in the aged population. This study aims to analyze the epidemiological characteristics of patients over 60 years of age with breast cancer in a private clinic in the city of Criciúma, Santa Catarina. Methods: This is a retrospective observational study, with collection of primary and secondary data and a quantitative approach. The sample was obtained through the analysis of 76 medical records and questionnaires, between 2014 and 2018. Results: The mean age of the patients was 70.39 years. The mean age of menarche and menopause was 13.23 and 49.48 years, respectively. Regarding the body mass index, 38.4% had some degree of obesity. Most elderly women (81.8%) were non-smokers. Evenly, 92.3% were non-alcoholics. Most cancers were detected by mammography (39.3%). Conservative surgery was predominant (74.2%). The association between radiotherapy and hormone therapy was the predominant adjuvant therapy (48.7%). Neoadjuvance was performed in 15 patients, 9 of whom underwent neoadjuvant chemotherapy (60.0%). The most used hormone therapy was anastrozole (88.9%). The most common side effects related to hormone therapy were isolated muscle pain (35.7%) and associated hot flushes (21.4%). There was a predominance of invasive ductal carcinoma (59.2%) and Luminal A subtype (43.6%). Conclusion: Aged patients usually present with smaller and less aggressive tumors, mostly submitted to less aggressive treatments.
Benign breast tumors: epidemiological profile and therapeutic conduct at the escola paulista de medicina
Authors: Peixoto João Bueno Vitor , Araújo Joaquim Teodoro , Elias Simone , Nazário Afonso Celso Pinto , Facina Gil
Published: January 2021

Introduction: Breasts represent an important site for the development of diseases. It is known that 80% of the palpable masses of the breast are of benign origin. Benign breast diseases range from inflammatory to neoplastic processes. Objectives: to evaluate the clinical and epidemiological characteristics of patients diagnosed with benign breast tumor at the Mastology outpatient clinic of the Universidade Federal de São Paulo (UNIFESP). Methods: 1,532 medical records, available on the electronic platform PEP-HUHSP through the ICD D24 (benign breast cancer) and N63 (unspecified breast nodule), of patients referred to the service between July 2008 and July 2017 were reviewed. After applying exclusion criteria, 403 medical records were submitted to data collection and tabulation in Excel, followed by statistical analysis using the IBM SPSS Statistics 23 software. The study in question was approved by the Research Ethics Committee of UNIFESP (CEP UNIFESP), in the Teaching and Research Coordination of Hospital São Paulo – Hospital Universitário/UNIFESP (CoEP of HSP-HU/UNIFESP) and exempted from the application of the Informed Consent by the same organs. Results: In the 9-year period, the following results were obtained: mean age was 39.3 years. Comorbidities: smoking (16.4%), SAH (16.8%) and dyslipidemia (6.3%). Family history of breast and/or ovarian cancer accounted for 16.6%. Mean age of menarche and menopause, respectively, were 12.7 and 42.5 years. Causes of referral: "alteration in image examination" (38.3%), "lump in the breast" (33.3%), "follow-up due to previous nodules" (16.5%). Anatomopathological report: fibroadenoma (41%), breast cysts (16%), phylloid tumors (3%), and papilloma (1%). Mean number of consultations per patient until discharge or abandonment of follow-up: three. Choice behavior: expectant (85.2%). Conclusion: The epidemiological profile of patients referred to the UNIFESP tertiary mastology service was mainly composed of women of childbearing age and nulliparous women, whose main comorbidities were smoking and SAH, in the great majority with no family history of breast cancer. Regarding the consultation, the main reason for referral is the findings on imaging exams, and, specially, patients would bring their breast USG along, which surpassed mammography by 34.1%. The choice for biopsy was restricted, present in approximately 1/3 of the cases, but pointed out that the most prevalent nodule is fibroadenoma, followed by phylloid and papilloma tumors. Nevertheless, there was a predilection for expectant conduct. On average, there were regular follow-ups for 1.5 years, followed by a significant dropout rate.
Analysis of variators in the brca1 and brca2 genes by ngs in patients from central brazil with suspected hboc syndrome: a new pathogenic variant identified
Authors: Goveia Rebeca Mota , Silva Paula Francinete Faustino da , Teixeira Thais Bomfim , Freitas Ruffo de , Lacerda Elisângela de Paula Silveira
Published: January 2021

About 10‒15% of breast cancer cases are due to deleterious germ changes, more than half of which are located in the BRCA1 or BRCA2 genes. The screening of variants in these genes for patients at risk brings benefits for better clinical management of the patient as well as for the prevention of disease recurrences both in the proband and in their relatives. The profile of genetic variants is little known to the Brazilian population and, to date, there are no published data for the population of the central region of the country. This study aimed to analyze the profile of pathogenic variants (VP) and of uncertain significance (VUS) in the BRCA1 and BRCA2 genes in this population. We selected 102 patients seen at Hospital das Clínicas, Universidade Federal de Goiás, with clinical diagnosis of invasive ductal carcinoma that met the criteria of the National Comprehensive Cancer Networking 2016/2 for hereditary breast and ovarian cancer syndrome. A collection of 4mL of peripheral blood was carried out and submitted to subsequent extraction of genomic DNA, carried out using the PureLink kit (Invitrogen). The genes in question had all their exon-intron regions sequenced using the MiSeq device (Illumina) and the raw data were evaluated using the Sophia DDM software. The risk of in silico pathogenicity of the VUS was analyzed by the software POLYPHEN2, MutationTaster, SIFT, ESP5400, G1000, GnomAD. Of the total of 102 patients evaluated in this study, 22 (21.56%) had PV or VUS in the BRCA1 or BRCA2 genes. Of these, 16 patients (72.81%) had pathogenic variants, eight with PV in BRCA1 (c.5266dupC (2), c.3331_3334delCAAC, c.211A>G, c.3228_3229delAG, c.3700_3704delGTAAA, c.4484G>T and c.5305_5306ins20) and eight with PV in BRCA2 (c.156_157insAlu, c.4829_4830delTG, c.8488-1G>A, c.6405_6409delCTTAA (3), c.517-1G>A, c.2808_2811delACAA). A total of 7 patients (31.8%) presented VUS in these genes, one in the BRCA1 gene (c.179A>G) and five in the BRCA2 gene (c.280C>T, c.811G>A, 1096T>G, 1441A>G and c.5270A>G) of which only the variant c.1441A>G had low pathogenic potential in silico. A new PV still not described in the literature was also identified, variant c.5305_5306ins20 in the BRCA1 gene. These data suggest that all patients at risk in this population should be evaluated for PV or VUS in the BRCA1 and BRCA2 genes since the presence of these variants can help in the patient's prognosis and disease prevention.
Weekly evaluation of estrogen α and progesterone receptors in the mammary epithelium of women after the use of combined oral hormonal contraceptives for one month
Authors: Araújo Joaquim Teodoro de , Taniguchi Celso Kazuto , Junior Anastasio Berrentini , Fenile Rogério , Nazário Afonso Celso Pinto
Published: January 2021

The increased risk of breast cancer (BC) is the most controversial adverse effect of combined oral hormonal contraceptives (COHC). An evaluation of hormone receptors (HR) revealed that their expressions are inversely proportional to the rate of cell proliferation, with a hierarchy where proliferative cells would be controlled by paracrine factors released by positive HR cells. Thus, the greater the proliferation, the greater the risk of the actions of environmental carcinogens. Compare the expressions by immunohistochemistry (IHC) of estrogen α (ERα) and progesterone receptors (PR) weekly in the mammary epithelium (ME) of patients using COHC for one month with those in the natural cycle. Retrospective cohort study of 118 women, 42 of whom were excluded and with a final sample of 76 women. Study group (A) consisted of 31 users of COHC with 30 µg of ethinyl estradiol (EE) and 150 µg of levonorgestrel (L), and control group (B), 45 non-users of COHC. In parity comparison, the Fisher's exact test was used, and for the mean ages, the Student’s t-test for independent samples. The Generalized Estimation Equation (EEG) model was used to evaluate ERα and PR counts over the four weeks and compare them. The Analysis of Variance (ANOVA) with two fixed factors and the Kolmogorov-Smirnov test were used to compare the total ERα and PR counts. Statistical analyses were performed using the SPSS 20.0 and STATA 12 programs, with a significance level of 5% (p≤0.05). As for age, group B had a mean age of 23.7±5.9 years compared to group A, with a mean age of 20.5±5.1 years, statistically significant p=0.016. With regard to parity, group A presented 83.9% of nulligravida versus 73.3% in group B, with p=0.164 without statistical significance. According to GEE, group A had higher mean percentages of ERα (p<0.001) and PR (p<0.001) when compared to women in the control group. The expressions of the IHC of the ERα and PR in percentages, weekly in the ME of the patients in the users of COHC presented higher mean percentages of ERα and PR, both statistically significant, when compared with non-users.
Análise de carcinomas mamários bilaterais: Um perfil das pacientes de um serviço de referência
Authors: Pasetto Camila Vitola , Budel Lucas Roskamp , Batista Bruno Ribeiro , Andreoli Mariana de Nadai , Budel Vinicius Milani
Published: January 2021

Introduction: Bilateral breast cancer (BBC) is a rare clinical entity. This pattern of neoplasia can be considered synchronous (simultaneous) or metachronous (1 month to 1 year later). Objective: To select cases of BBC patients seen at HC-UFPR and to recognize in these patients clinical and family characteristics, histological and immunohistochemical patterns, and incidences of synchronous/metachronous occurrences. Method: An observational and analytical study of BBC cases of patients treated at HC-UFPR, from January 2003 to October 2019, based on the analysis of medical records, was developed. Result: 42 patients with BBC were selected and 4 patients were excluded from the study due to incomplete information in the medical record. The incidence of BBC in the surveyed period was 3.64%. All patients are women with a mean age of 51.82 years. White ethnicity is the most prevalent one (82%). With regard to menopausal status, 42% of the subjects are pre-menopausal and 58%, post-menopausal. Regarding parity, only 16% were nulliparous. Half of the patients have a positive family history for neoplasms, with breast cancer present in 46%, ovarian cancer in 16%, and other topography in 68%. In this sample, the synchronous tumor was present in 55% of the patients and the metachronous tumor in 45%. Regarding the patients’ initial clinical staging, 61% presented with locally advanced tumor at the first consultation. In the group of synchronous tumors, the ductal type was the most frequent one (93%), followed by the lobular type (7%). Regarding immunohistochemical subtypes, patients had Luminal B tumors (43%), followed by HER (29%), Triple negative (24%), and Luminal A (5%). Comparing the immunohistochemical profile in both tumors, 62% were in agreement and 48%, in disagreement. In the group of metachronous tumors, the mean time between the diagnosis of the first tumor and that of the second tumor was 5.68 years. The most common histological type was ductal carcinoma (73%), followed by lobular carcinoma (11%), medullary carcinoma (9%), and metaplastics (7%). Regarding the immunohistochemical profile, the most present was Luminal B in 32%, Luminal A in 29%, Triple negative in 24%, and HER 2 in 15%. The immunohistochemical profile was consistent in only 29% of the patients. Conclusion: In this sample, BBC is associated with relevant family history, with a pattern of presentation, synchronous; frequently, ductal is histological and Luminal B is immunohistochemistry.
Comparison between the american joint committee on cancer (ajcc) anatomic and prognostic stages for breast cancer
Authors: Cardoso Mariana Soares , Solino Marcelo Antonini Matheus de Paula
Published: January 2021

Introduction: The knowledge regarding the biology of breast cancer has grown substantially and resulted in the identification of different breast cancer subtypes based on their molecular profile, which led to an important change in treatment, from a standardized therapy to a personalized one. A panel of experts and AJCC representatives were responsible for preparing the most recent Cancer Staging Manual. The panel recognized the clinical usefulness of biological factors such as histological grade, expression of hormone receptors (HR; estrogen and progesterone) and overexpression and/or amplification of the human epidermal growth factor receptor 2 (HER2) in predicting patient survival7 and incorporated data regarding these biomarkers in the new staging system. In addition, for eligible cases, the ‘Recurrence score’ was also incorporated, generated by the analysis of OncotypeDx (genomic test). The new manual, therefore, started to use 3 stagings. Anatomical staging – based on the classic TNM; clinical prognostic staging and pathological prognosis – association of TNM with prognostic biomarkers (using clinical data in the first and data after surgical treatment in the second). Objective: To verify the agreement between anatomical staging from the 7th edition of the AJCC manual and the prognosis from its 8th edition in a cohort of breast cancer patients at the Hospital do Servidor Público Estadual de São Paulo. Methodology: Observational and cross-sectional study, which evaluated patients undergoing surgical treatment at Hospital do Servidor Público Estadual from March, 2014 to March, 2019. Information was collected regarding age, menopausal status, tumor characteristics, anatomical and clinical staging, neoadjuvant chemotherapy, adjuvant chemotherapy and radiotherapy, and type of surgery performed. Patients were staged using the digital platform “TNM8 Breast Cancer Calculator”. Results: 805 patients were included in the analysis. All patients were females aged between 29 and 97 years, mostly in the post-menopausal period (78.88%). 74.04% of cases were positive for ER, 66.21% PR-positive, and 88.07% HER2-negative. Prognostic staging downgraded a total of 285 out of 805 patients (35.4%). Almost all of the cases that decreased in staging were ER and/or PR+ (283 of 285). Most of those who went up were Triple Negatives (100 out of 111). Conclusion: Prognostic Staging changes the staging in almost half of the cases and there was a greater number of decreased staging in total and an association of increased staging with tumors considered to have a worse prognosis, which is in agreement with several studies already carried out since the new manual came out.
Topographic distribution of lymphocyte infiltrate in triple negative tumors and its impact on the survival of the patient with breast cancer
Authors: Peixoto Jose , Guimarães Marcos Duarte , Seabra Maria Aparecida , Campos Olávio , Pascoal Ana Carolina Ferraz
Published: January 2021

Introduction: Tumor infiltrating lymphocytes (TIL) are generally measured using subjective methods unable to differentiate subpopulations and to locate immune cells in the tumor microenvironment. The identification and location of these cells is of great importance as they present different responses to immune stimuli. Objective: to analyze the presence of TIL in early-stage breast cancer of the triple negative molecular subtype, and to evaluate the association of TIL with the overall survival time (OS). Methods: a cross-sectional study was carried out at the Hospital de Câncer de Pernambuco (HCP), where patients diagnosed with triple negative breast cancer were selected between 2009 and 2013. TIL evaluation was performed by two methods: on slides stained with hematoxylin and eosin (H&E), by two pathologists blindly and independently, and on slides submitted to immunohistochemistry, with CD3 and CD8 lymphocyte marking. In this case, the sample was then subjected to computerized histophotometry and morphometric analysis. Results: 87 patients were included, of which 22 patients had an event in the follow-up period. The evaluation of TIL, by two pathologists, showed regular agreement between the evaluators, with an intraclass correlation coefficient of 0.574 and p=0.001. CD3+ and CD8+ lymphocytes were in greater quantity in the intra tumor area compared to those outside the tumor margin (extra tumor). When the association between the presence of lymphocytes and the patient’s OS was analyzed, a directly proportional relationship with this survival was observed, that is, the greater the amount of lymphocytes, the lower the risk of death. Conclusion: results suggest that there is a correlation between the tumor lymphocyte infiltrate of triple negative breast cancer and OS. As this tumor subtype has a poor prognosis and does not have specific target therapy, TIL analysis can be explored as a prognostic marker for the treatment of breast cancer.
Role of fat grafting in late breast reconstruction after failure of immediate breast reconstruction with implants – experience of hospital de clínicas in porto alegre
Authors: Damin Andréa Pires Souto , Tomazzoni Gabriela Dinnebier , Zucatto Angela Erguy , Zancan Maira , Biazús Jorge Villanova
Published: January 2021

Introduction: The breast reconstruction techniques with tissue expanders and silicone implants were the most used ones in the past decade. Immediate post-mastectomy reconstruction can evolve to loss of implants, causing significant morbidity to the patients. The knowledge of techniques that use fat grafting has allowed the use of more late reconstruction techniques. Objectives: To assess the application of fat grafting in late breast reconstruction in patients submitted to mastectomy with immediate reconstruction, who presented loss of implant (expanders and prostheses). Method: Cross-sectional study carried out through data collection in electronic medical records. We selected patients from the Mastology Service in HCPA, submitted to immediate breast reconstruction with expanders/prostheses in the period from May/2000 to May/2019. Results: We analyzed 241 cases of mastectomy with immediate breast reconstruction based on implants – 127 (52.7%) expanders and 114 (42.3%) direct prosthesis. In 24 cases (10.0%), there was loss of implants. Among these 24 patients, 20 (83.3%) had not undergone radiotherapy before mastectomy, and 4 (16.7%) had been submitted to previous radiotherapy. Of these, in 18 cases (75.0%), late reconstruction was performed: 3 cases (20.8%) of reconstruction with rectus abdominis flap (TRAM), 4 cases (23.4%) of reconstruction with latissimus dorsi muscle flap (LD), 1 case (5.5%) of fat grafting with flap planning, 6 cases (33.6%) of exclusive flap grafting, and 4 cases (23.4%) of expander/prosthesis after the plastron fat grafting. Conclusions: Breast reconstruction after the loss of expanders/prosthesis can be carried out through several surgical techniques. The knowledge of the mastologist about the different techniques aims at providing the best choice to be used, according to the individual risk profile of each patient. Plastron fat grafting after loss of implant is an important ally in late reconstruction, improving the local conditions and allowing, in our sample, the prevention of the indication of flaps 57% of the time.
Impact of Public Debt, Lending Interest Rate, Public Spending and Money Supply on Private Consumption in South Asian Countries: An Econometric Analysis
Authors: HAMEED MUHAMMAD REEHAN , SARWAR GHULAM , ABDULLAH MUHAMMAD
Published: January 2021

The public debt of South Asian countries has witnessed a continuous increase from the last three decades which has badly affected the household private consumption expenditures. High public debt can lead to steep losses for banks, both domestic and international, undermines the stability of financial systems in both the crisis-hit country and others. This can hit economic growth as well as private consumption. The purpose of this study is to examine the impact of public debt on private consumption in South Asian countries i.e. Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka. Besides public debt, the impact of some other important macroeconomic, fiscal, and monetary variables like lending interest rate, public spending and money supply have also been examined. For this purpose, 31 years of panel data from 1990 to 2020 of South Asian countries have been taken. The study has used a variety of econometric techniques like Robust Least Square Regression, Panel Cointegration, Error Correction Model (ECM), Wald test, and Panel Fully Modified Least Squares (FMOLS) approach to examine the short-run and long-run relationship among the variables. The results of Robust Least Square Regression indicate that public debt discourages private consumption. The lending interest rate also badly affected private consumption. The other variables like public spending and money supply have a favorable impact on private consumption. The results of the Kao Residual Panel Cointegration Test and the Johansen Fisher Panel Cointegration Test indicate that there exists a long run relationship among the variables. The results of the ECM and Wald Test reveal that a long run and short-run causality is running from independent variables to the dependent variable respectively. The study recommends that by using monetary and fiscal policies effectively the private consumption and economic growth can be stimulated in the economy. Keywords: South Asia, Public Debt, Private Consumption, Lending Interest Rate Public Spending, Money Supply, Robust Least Square Regression, ECM, FMOLS, Wald Test.
Competing in the Era of Industrial Revolution 4.0 and Society 5.0
Authors: Ellitan Lena
Published: January 2021

The industrial revolution 4.0 presents challenges that must be faced by the business world, namely the lack of adequate HR (Human Resource) skills, the problem of security of communication technology, the reliability of the stability of production machines, the inability to change by stakeholders, and the number of job losses due to automation. Society 5.0 offers a human-centered society that makes a balance between economic progress and the resolution of social problems through a system that is highly connected through cyberspace and the real world. If society 4.0 allows anyone to access also share information on the internet. Society 5.0 is an era where all technology is part of humanity itself. To take advantage of opportunities and answer the challenges of the industrial revolution 4.0, Indonesian people in particular are required to have data, technology and human literacy capabilities. Data literacy is needed by HR to improve skills in processing and analyzing big data for the benefit of improving public and business services. Technology literacy shows the ability to utilize digital technology to process data and information, while human literacy must be mastered because it shows the element of soft skills or the development of individual character to be able to collaborate, be adaptive, and innovative. Indonesia is demanded to be able to follow industry 4.0 workflows juxtaposed with society 5.0. The need for human resources in several business fields is still very massive if all of them are carried out by robotics. Indonesia is a developing country with a fairly dense population that is certainly able to align between the needs of industry 4.0 and society 5.0. Leadership in organizations must stay alive so that every innovative competitive strategy is able to run with the existing vision. To go to the era of society 5.0 the government is obliged to continuously control it.
Horta escolar: uma proposta pedagógica e interdisciplinar vivenciada em uma escola indígena municipal, Dourados – MS
Authors: Rodrigues Maria Adriana , Martins Luís Antonio , Soares Stela
Published: January 2021

O estudo teve como objetivo apresentar atividades interdisciplinares, estas tiveram a participação dos professores das turmas dos sextos anos do ensino fundamental. A metodologia foi elaborada com cada professor especifico de cada componente curricular ofertado para os sextos anos. A horta foi utilizada como um recurso didático e interdisciplinar. Os temas estudados foram: sustentabilidade; criatividade; inovação; impacto na comunidade e benefício gerado pela tecnologia para o aprendizado do aluno. Analisando as práticas desenvolvidas concluímos que há diversas possibilidades de se fazer trabalhos interdisciplinares em uma horta, associando a teoria à prática escolar. A interdisciplinaridade pode ser considerada um produto inacabado ou polissêmico como é citado por alguns autores e deve ser renovado, repensado a cada ano, a cada etapa realizada de um projeto e a cada atividade desenvolvida em uma sala de aula, levando-se em consideração o contexto social local e regional em que estamos inseridos no momento.
A institucionalização da EaD nas universidades públicas: um relato de experiência da UDESC
Authors: Ripa Roselaine
Published: January 2021

Este trabalho tem o objetivo de apresentar o processo de institucionalização da modalidade a distância na Universidade do Estado de Santa Catarina – UDESC, a partir da história do Centro de Educação a Distância – CEAD criado em 2002. Iniciamos com uma breve reflexão sobre a educação a distância nas universidades públicas brasileiras nas últimas décadas e, na sequência, apresentamos os marcos legais que têm apoiado o processo de institucionalização da EAD na UDESC, com destaque à política de EAD da UDESC aprovada em 2014 e sua relação com o Plano de Desenvolvimento Institucional da UDESC do período de 2017 a 2021 e com as novas diretrizes do ensino de graduação elaboradas em 2019. Para finalizar o relato, apontamos as conquistas e alguns desafios que ainda envolvem a modalidade a distância na instituição.
Contribuições das observações de campo do estágio curricular supervisionado para a formação docente: um relato de experiência
Authors: Ferraz Gabriel
Published: January 2021

A docência se caracteriza como uma profissão suscetível a modificações ao longo do tempo, sobretudo no que diz respeito às teorias e práticas pedagógicas. Nesse sentido, é de suma importância que os professores sempre busquem se atualizar a fim de aperfeiçoarem suas metodologias de ensino e assim tornar a aprendizagem de seus alunos mais significativa. Diante disso, o presente trabalho consiste em um relato de experiência escrito sob a ótica de um estagiário do Curso de Licenciatura em Ciências Biológicas da Universidade Federal do Piauí (UFPI) no qual objetiva-se em ressaltar a contribuição das observações de campo realizadas em duas escolas públicas durante a disciplina de Estágio Curricular Supervisionado e a importância dessa disciplina para a formação e construção de um perfil de atuação dos futuros docentes.
Relato de experiência durante estágio supervisionado de observação no ensino fundamental e médio
Authors: Pereira Arielly Alves
Published: January 2021

O relato apresentado faz menção às atividades desenvolvidas autora– estagiária na disciplina de estagio supervisionada II em Licenciatura em ciências biológicas da Universidade Federal do Piauí (UFPI), considerando as observações de campo feitas tanto no ensino fundamental maior e ensino médio. Através deste trabalho expandiu o aprendizado acadêmico que adquirimos ao longo do curso. O estágio proporciona diversos tipos de conhecimentos práticos, e fora da universidade o licenciando se vê na necessidade de aplicar todo seu conhecimento teórico e que este conhecimento o auxilie em suas futuras práticas pedagógicas, pois sem este momento de observação de campo não poderíamos ter esse tipo de vivenciamento de momentos reais do nosso futuro campo de atuação.
Vivir y morir sin sentido. Testimonios juveniles en contextos de marginalidad urbana
Authors: Arevalos Dario Hernán
Published: January 2021

Este artigo propõe analisar, sob uma perspectiva socioeducativa, os sentidos que os jovens atribuem às mulheres devido à falta de estima e reconhecimento que experimentam no cotidiano. Testemunhos para estudantes de escolas secundárias urbanas periféricas em Ciudad de La Plata, Buenos Aires, Argentina; Ele nos permite examinar como o conhecimento prático da violência autodestrutiva se refere a um profundo mal-estar que tem um lugar no tecido social. Conclui-se que a instituição escolar em contextos de marginalidade urbana ocupa um lugar central na construção de uma narrativa do presente e do futuro.
Formação inicial e continuada: o papel do Laboratório Interdisciplinar de Formação de Educadores - LIFE/UFGD
Authors: Biscaro Adriana De Fátima Vilela , Souza Sandra Regina Oliveira de , Rodrigues Maria Adriana Torqueti , Cunha Aldrin Cleyde , Cruz Adailton José Alves da
Published: January 2021

Atualmente a Universidade Federal da Grande Dourados (UFGD) conta com um espaço “comum” de formação docente, denominado Laboratório Interdisciplinar de Formação de Educadores (LIFE/UFGD), que vem atuando deste 2015 na formação inicial e desempenha também um papel importante na formação continuada para os professores da Rede Básica de Ensino. O presente artigo tem como objetivo divulgar este espaço de formação e apresentar algumas das atividades que vêm sendo realizadas a partir das formações com bolsistas e professores parceiros do projeto. O desenvolvimento das atividades formativas, dá-se por discussões de metodologias de ensino interdisciplinar, fundamentadas nas pesquisas de Ivani Fazenda, Edgar Morin, Gaudêncio Frigotto e outros estudiosos que contribuem para as discussões do ensino interdisciplinar. As ações interdisciplinares realizadas nas escolas são planejadas de acordo com os Planos Pedagógicos das escolas parceiras do LIFE/UFGD, possibilitando sua inserção no contexto escolar da rede pública. Espera-se que o LIFE/UFGD possa continuar contribuindo para uma formação diferenciada e com qualidade, ampliando suas ações à medida que novas demandas das escolas e possivelmente da própria UFGD sejam solicitadas a este espaço de formação.
O trabalho docente e o licenciado em computação
Authors: Peviani Claudia Regina Tinós , Paniago Maria Cristina Lima
Published: January 2021

O trabalho docente é um tema recorrente nas pesquisas em Educação. Termos como identidade profissional, profissionalização, profissionalidade e valorização profissional são amplamente utilizados nas discussões e reflexões sobre o desenvolvimento do trabalho docente. O objetivo deste artigo é refletir sobre trabalho docente do Licenciado em Computação nos ambientes escolares. Por meio da reflexão teórica, a metodologia utilizada foi a revisão bibliográfica baseado nas leituras de artigos, capítulos de livros e alguns documentos referentes ao curso de Licenciatura em Computação. O Licenciado em Computação é um profissional com formação docente que lhe permite exercer suas habilidades e competências em ambientes escolares e não escolares, todavia os espaços escolares por eles ocupados ainda são muito escassos ou ocupados por outros docentes de outras áreas de conhecimento.
Concepção de currículo como construção histórico-social: breves considerações
Authors: Viegas Elis Regina dos Santos , Santana Cristina Fátima Pires Ávila , Noda Claudia Marinho Carneiro
Published: January 2021

O presente trabalho tem por objetivo analisar as diferenças conceituais do entendimento de currículo, apontando a influência das determinações sociais, históricas, culturais, econômicas, políticas e ideológicas na construção desse conceito. Para tanto, a opção metodológica adotada situa-se como de natureza teórico-bibliográfica dentro de uma abordagem qualitativa de análise. Buscamos oportunizar uma aproximação a esse conceito, compreendendo os fundamentos, os determinantes, os modelos e as implicações do Currículo para as práticas pedagógicas. As leituras encaminhadas indicam que a compreensão do que seja currículo integra-se a distintas concepções que, por sua vez derivam dos diversos modos de como a educação é concebida historicamente, bem como das influências teóricas que a afeta e se fazem hegemônicas em um dado momento/período. Entretanto, inferimos a partir do referencial teórico analisado que há, de fato, elementos comuns no entendimento do que é denominado de currículo, como a ideia de organização (prévia ou não), de experiências e/ou situações educativas promovidas por docentes e/ou redes de ensino de forma a materializar o processo de ensino-aprendizagem.
Projetos de leitura na biblioteca escolar: o que dizem as crianças sobre o vivido
Authors: Queiroz Jaqueline Areco de , Yamin Giana Amaral , Vieira Juliane Ferreira
Published: January 2021

Este artigo apresenta o resultado de uma pesquisa que envolveu crianças do Quinto Ano do Ensino Fundamental de uma escola pública de Dourados, estado de Mato Grosso do Sul (MS). O estudo desocultou a avaliação dos alunos a respeito das vivências das quais participaram no âmbito da biblioteca da sua escola e que foram protagonizadas por profesoras em formação do Curso de Pedagogia, da Universidade Estadual de Mato Grosso do Sul (UEMS). Para atingir aos objetivos, primeiramente, realizou-se uma revisão bibliográfica acerca da contribuição da biblioteca escolar para a formação do sujeito leitor e, também, de estudos ligados à Sociologia da Infância. Posteriormente, os alunos foram convidados a avaliar os projetos, ocorridos no ano de 2016 no espaço da biblioteca – voltados a atividades de literatura em diálogo com múltiplas linguagens. Como instrumento de pesquisa, aplicou-se um questionário. Os dados coletados revelaram que as crianças aprovaram as atividades da biblioteca. Elas acreditam que aprenderam a ler melhor, que se interessaram por histórias, que conheceram novas obras e, ainda, apontaram como o melhor projeto desenvolvido pelas estudantes da UEMS o “Histórias de Assustar”. A pesquisa comprovou que as ações desenvolvidas pelo curso de Pedagogia UEMS atingiram aos seus objetivos.
A história da educação física escolar no Brasil: leis e decretos norteadores
Authors: Mommad Maicon Luiz
Published: January 2021

A Educação Física Escolar no Brasil é fruto de uma construção de políticas públicas educacionais, as quais veem sendo materializadas por Leis, Decretos e instrumentos legislativos que definem seus objetivos, metas, funções e responsabilidades de todos os entes envolvidos. O presente artigo se desenvolveu por pesquisas bibliográficas e documentais, focadas em documentos oficiais, como, leis, decretos, portarias e outros documentos publicados pelo Governo Federal Brasileiro, com recorte histórico de 1937 a 2003, os quais se justificam os períodos da 1º Constituição Federal de 1937 a Lei de Diretrizes e Bases da Educação de 1996 e suas portarias complementares. O objetivo da pesquisa é demonstrar o desenvolvimento histórico das políticas púbicas educacionais no campo de educação física escolar, focando principalmente no período em que a disciplina adquire status de componente curricular obrigatório na educação básica.
O ensino de artes visuais para pessoas com deficiência visual ou cegueira
Authors: Sinãni Marília Cláudia Favreto , Calves Kimberly Weiss , Paes Paulo Cesar Duarte
Published: January 2021

Este artigo visa contribuir com a abordagem no Ensino de Artes Visuais exercido na área de educação especial específica para alunos com deficiência visual e cegueira. No qual o ISMAC – Instituto Sul Mato Grossense para Cegos Florivaldo Vargas localizado em Campo Grande/MS, colaborou como sede para a pesquisa de campo. Como se dá o Ensino de Artes Visuais para alunos que possuem alguma deficiência no campo da visão? Sendo assim, a partir de análises de conteúdos, propomos outras perspectivas para o planejamento das aulas práticas direcionadas a estes alunos, sem que percamos a essência da arte e a importância das referências visuais produzidas ao longo da história. Dentre as problemáticas encontradas em campo, levantamos a evidente presença da prática artística associada a objetos utilitários, por isso adotamos a perspectiva histórico-crítica de Lev Vigotski dentro do ensino da arte, para elucidarmos possíveis alternativas para a valorização do processo de criação dos alunos com deficiência visual na qual a aula de artes visuais torna possível a fruição criadora.
A relação entre educação e pobreza nas publicações da Revista Brasileira de Educação (2004-2019)
Authors: Martins Bárbara Amaral , Rückert Fabiano Quadros
Published: January 2021

O presente trabalho aborda a relação entre educação e pobreza (REP) a partir de artigos publicados na Revista Brasileira de Educação no período entre 2004 e 2019. O objetivo consiste em analisar as interpretações construídas pelas pesquisas acadêmicas a respeito das vinculações entre pobreza e educação. Para atingir este objetivo, consultamos os sumários de todas as edições que se enquadram no marco cronológico fixado, identificamos um conjunto de artigos que tratam da REP nas suas diferentes manifestações, e, posteriormente, realizamos uma análise de conteúdo do respectivo conjunto. Os resultados indicam que a REP é analisada por diferentes enfoques e interpretada a partir de múltiplas perspectivas (histórica, política e cientométrica) e ressaltam a complexidade da relação entre educação e pobreza.
English summaries
Authors: Kivistö Mari Susanna
Published: January 2021

Article summaries in English
Kuulemistilaisuus institutionaalisena vuorovaikutuksena lapsen huostaanoton valmisteluprosessissa
Authors: Välikoski Tuula-Riitta , Pösö Tarja , Huhtanen Raija
Published: January 2021

Artikkelissa tarkastellaan lapsen huostaanottoon liittyviä kuulemistilaisuuksia institutionaalisena vuorovaikutuksena. Kuulemisen tarkoitus on selvittää asianosaisten mielipide huostaanottoon ja siihen liittyvään sijaishuoltoon sijoittamiseen. Koska mielipide – suostumus tai vastustus – vaikuttaa huostaanoton päätöksentekoprosessiin, kuuleminen on vuorovaikutustilanteena tärkeä. Teoreettisen taustan luovat organisaatioviestinnän institutionaalinen teoria ja sosiokulttuurinen näkökulma. Aineistona ovat litteroidut kuulemistilaisuudet (n=16), joissa ilmenevää vuorovaikutusta sekä osapuolien välisiä viestintäsuhteita analysoidaan temaattisesti. Vuorovaikutuksen tutkimuksen ohella tarkastelussa hyödynnetään oikeus- ja sosiaalityön tutkimuksen näkökulmia. Vaikka kuulemistilaisuus on virallinen, sen osapuolten väliset viestintäsuhteet asymmetriset ja asiakirjoilla siinä tärkeä rooli, sisältää tilaisuuden vuorovaikutus myös läheisyyttä ja välittämistä osoittavia viestintätekoja. Sosiaalityöntekijät eivät ohjaile asianosaisten mielipiteitä mihinkään suuntaan. Kriittiset kohdat liittyvät informaation tarjoamisen, mielipiteen ilmaisemisen ja dokumentoinnin ajoituksiin.
Utopianism in the Age of Capitalocene
Authors: Lakkala Keijo
Published: January 2021

This article explores the social and political imagination of ‘the Anthropocene’ and the utopian counter images that can be derived from it. From the utopian studies perspective, I argue that the Anthropocene cannot provide sufficient societal alternatives for the current ecological predicament. This is due to the fact that the concept of Anthropocene relies too heavily on the image of abstract humanity to be able to offer real societal alternatives. It cannot name the social system we live in and, therefore, it cannot fundamentally challenge existing social arrangements. Based on utopian social theory, I conceptualize utopia as a counter image of the present motivated by a desire for better being. The contents and the politically transformative potentials of utopian counter-images depend on the conceptualization of the present itself. I contrast the utopian potentials of ‘the Anthropocene’ with that of ‘the Capitalocene’ which is more apt in outlining the social conditions of the present. Thus, the Capitalocene as a concept opens up more radical possibilities for imagining societal alternatives by conceptualizing the present socially.