bluuebunny/crossref_metadata_2025 huggingface dataset:
Inverted internal limiting membrane-flap technique for large macular hole: a microperimetric study
Authors: Sborgia Giancarlo , Niro Alfredo , Sborgia Alessandra , Albano Valeria , Tritto Tiziana , Sborgia Luigi , Pastore Valentina , Donghia Rossella , Giancipoli Ermete , Recchimurzo Nicola , Boscia Francesco , Alessio Giovanni
Published: October 2019

Background

Inverted Internal Limiting Membrane (ILM)-flap technique would seem to lead to higher closure rate and better visual acuity than traditional procedure with ILM peeling for the treatment of large macular hole (LMH). Visual acuity recovery does not reveal many other functional changes related to surgical approach. Our purpose was to evaluate macular function and morphology over a 1-year follow-up after inverted ILM-flap technique for LMH by using microperimetry in order to predict visual prognosis.

Methods

This study was a prospective unrandomized single-center study. 23 eyes of 22 patients with idiopathic LMH, with a minimum diameter ranging from 400 to 1000 μm, were included. All patients underwent vitrectomy with inverted ILM-flap technique and gas tamponade. We analyzed macular hole closure rate and functional outcomes including best-corrected visual acuity (BCVA), macular sensitivity (MS) at central 12° and central macular sensitivity (CMS) at central 4°, and fixation behavior as bivariate contour ellipse area (BCEA, degrees2) at 68%, 95%, and 99% of fixation points measured by microperimeter, over a follow-up of 12 months.

Results

The macular hole closure rate was 98%. The BCVA improved from 20/230 (Logmar, 1.06 ± 0.34) to 20/59 (logMar, 0.47 ± 0.45) at last follow-up (p < 0.001). Retinal sensitivity and BCEA significantly improved (MS, p = 0.001; CMS, p < 0.0001; BCEA: 68%, p < 0.01; 95%, p < 0.01; 99%, p = 0.001). Multiple stepwise regression analysis showed the final BCVA was significantly associated with macular hole size (β = 0.002, p = 0.03), preoperative MS (β = − 0.06, p = 0.001) and BCEA at 95% and 99% of fixation points (β = − 0.12, p = 0.01; β = 0.06, p = 0.01).

Conclusions

Inverted ILM-flap technique for LMH results in good morphologic and functional outcomes. Macular hole size and microperimetric parameters as preoperative MS and BCEA have a predictive role on post-surgical visual acuity.
Plasma medicine for neuroscience—an introduction
Authors: Yan Xu , Ouyang Jiting , Zhang Chenyang , Shi Zhongfang , Wang Boran , Ostrikov Kostya ( Ken)
Published: October 2019

Plasma is an ionized gas. It is typically formed at high temperature. As a result of both the development of low-temperature plasma sources and a better understanding of complex plasma phenomena over the last decade, “plasma medicine” has become a booming interdisciplinary research topic of growing importance that explores enormous opportunities at the interface of chemistry, plasma physics, and biomedical sciences with engineering. This review presents the latest development in plasma medicine in the area of the central nervous system and aims to introduce cutting-edge plasma medicine to clinical and translational medical researchers and practitioners.
A multisectoral institutional arrangements approach to integrating civil registration, vital statistics, and identity management systems
Authors: Mills Samuel , Lee Jane Kim , Rassekh Bahie Mary
Published: October 2019

This paper reviews the essential components of a recommended institutional arrangements framework of integrated civil registration and vital statistics (CRVS) and civil identification systems. CRVS typically involves several ministries and institutions, including health institutions that notify the occurrence of births and deaths; the judicial system that records the occurrence of marriages, divorces, and adoptions; the national statistics office that produces vital statistics reports; and the civil registry, to name a few. Considering the many stakeholders and close collaborations involved, it is important to establish clear institutional arrangements—“the policies, practices and systems that allow for effective functioning of an organization or group” (United Nations Development Programme, Capacity development: a UNDP primer. New York: United Nations Development Programme, 2009). An example of a component of institutional arrangements is the establishment of a multisectoral national CRVS coordination committee consisting of representatives from key stakeholder groups that can facilitate participatory decision-making and continuous communication. Another important component of institutional arrangements is to create a linkage between CRVS and the national identity management system using unique identification numbers, enabling continuously updated vital events data to be accessible to the civil identification agency. By using birth registration in the civil registry to trigger the generation of a new identification and death registration to close it, this link accounts for the flow of people into and out of the identification management system. Expanding this data link to enable interoperability between different databases belonging to various ministries and agencies can enhance the efficiency of public and private services, save resources, and improve the quality of national statistics which are useful for monitoring the national development goals and the Sustainable Development Goals. Examples from countries that have successfully implemented the recommended components of an integrated CRVS and national identity management system are presented in the paper.
Text Mining in Electronic Medical Records Enables Quick and Efficient Identification of Pregnancy Cases Occurring After Breast Cancer
Authors: Labrosse Julie , Lam Thanh , Sebbag Clara , Benque Milena , Abdennebi Ines , Merckelbagh Hilde , Osdoit Marie , Priour Maël , Guerin Julien , Balezeau Thomas , Grandal Beatriz , Coussy Florence , Bobrie Angélique , Ferrer Loïc , Laas Enora , Feron Jean-Guillaume , Reyal Fabien , Hamy Anne-Sophie
Published: October 2019

PURPOSE

To apply text mining (TM) technology on electronic medical records (EMRs) of patients with breast cancer (BC) to retrieve the occurrence of a pregnancy after BC diagnosis and compare its performance to manual curation.

MATERIALS AND METHODS

The training cohort (Cohort A) comprised 344 patients with BC age ≤ 40 years old treated at Institut Curie between 2005 and 2007. Manual curation consisted in manually reviewing each EMR to retrieve pregnancies. TM consisted of first applying a keyword filter (“accouch*” or “enceinte,” French terms for “deliver*” and “pregnant,” respectively) to select a subset of EMRs, and, second, checking manually EMRs to confirm the pregnancy. Then, we applied our TM algorithm on an independent cohort of patients with BC treated between 2008 and 2012 (Cohort B).

RESULTS

In Cohort A, 36 pregnancies were identified among 344 patients (10.5%; 2,829 person-years of EMR). Thirty were identified by manual review versus 35 by TM. TM resulted in a lower percentage of manual checking (26.7% v 100%, respectively) and substantial time gains (time to identify a pregnancy: 13 minutes for TM v 244 minutes for manual curation, respectively). Presence of any of the two TM filters showed excellent sensitivity (97%) and negative predictive value (100%). In Cohort B, 67 pregnancies were identified among 1,226 patients (5.5%; 7,349 person-years of EMR). Similarly, for Cohort B, TM spared 904 (73.7%) EMRs from manual review and quickly generated a cohort of 67 pregnancies after BC. Incidence rate of pregnancy after BC was 0.01 pregnancy per person-year of EMR in both cohorts.

CONCLUSION

TM is highly efficient to quickly identify rare events and is a promising tool to improve rapidity, efficiency, and costs of medical research.
Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma
Authors: Plotkin Scott R. , Duda Dan G. , Muzikansky Alona , Allen Jeffrey , Blakeley Jaishri , Rosser Tena , Campian Jian L. , Clapp D. Wade , Fisher Michael J. , Tonsgard James , Ullrich Nicole , Thomas Coretta , Cutter Gary , Korf Bruce , Packer Roger , Karajannis Matthias A.
Published: October 2019

PURPOSE

Bevacizumab treatment at 7.5 mg/kg every 3 weeks results in improved hearing in approximately 35%-40% of patients with neurofibromatosis type 2 (NF2) and progressive vestibular schwannomas (VSs). However, the optimal dose is unknown. In this multicenter phase II and biomarker study, we evaluated the efficacy and safety of high-dose bevacizumab in pediatric and adult patients with NF2 with progressive VS.

PATIENTS AND METHODS

Bevacizumab was given for 6 months at 10 mg/kg every 2 weeks, followed by 18 months at 5 mg/kg every 3 weeks. The primary end point was hearing response defined by word recognition score (WRS) at 6 months. Secondary end points included toxicity, radiographic response, quality of life (QOL), and plasma biomarkers.

RESULTS

Twenty-two participants with NF2 (median age, 23 years) with progressive hearing loss in the target ear (median baseline WRS, 53%) were enrolled. Nine (41%) of 22 participants achieved a hearing response at 6 months (1 of 7 children and 8 of 15 adults; P = .08). Radiographic response was seen in 7 (32%) of 22 patients with VS at 6 months (7 of 15 adults and 0 of 7 children; P = .05). Common mild to moderate adverse events included hypertension, fatigue, headache, and irregular menstruation. Improvement in NF2-related QOL and reduction in tinnitus-related distress were reported in 30% and 60% of participants, respectively. Paradoxically, high-dose bevacizumab treatment was not associated with a significant decrease in free vascular endothelial growth factor but was associated with increased carbonic anhydrase IX, hepatocyte growth factor, placental growth factor, stromal cell-derived factor 1α, and basic fibroblast growth factor concentrations in plasma.

CONCLUSION

High-dose bevacizumab seems to be no more effective than standard-dose bevacizumab for treatment of patients with NF2 with hearing loss. In contrast to adults, pediatric participants did not experience tumor shrinkage. However, adult and pediatric participants reported similar improvement in QOL during induction. Novel approaches using bevacizumab should be considered for children with NF2.
Vernacular Story in and as Archives: (Re)MakingXingshi yanStories in Early Modern China and Korea
Authors: Ye Yuan
Published: October 2019

This article examines literary texts both as records transmitted through archives and as cultural sites recording preferred knowledge. It focuses on the late Ming-era (1368–1644) Chinese vernacular short story anthology Xingshi yan 型世言 (Exemplary Words for the World, ca. 1632)—the only extant copy preserved in the Kyujanggak Archives in South Korea—and its Chosŏn (1392–1910) rendition in the Korean alphabet, Hyŏngse ŏn, housed in the Jangseogak Archives. Xingshi yan, taking seriously the Chinese vernacular literature’s claim of being “unofficial history,” provides its own historical narrative of the Ming at the end of the dynasty when it was threatened by the Manchus. Recording the notable Ming figures and affairs, this anthology creates a literary archive furnishing materials for Ming history. In addition, this article points out the significance of the Kyujanggak Xingshi yan in solving the ambiguous textual origins of several Chinese vernacular story anthologies that were previously associated with the famous Second Amazement. Eventually, it traces the trajectory of how Xingshi yan was preserved in the Korean royal archives and appreciated by royal family members, and how its stories were rendered into the Korean alphabet for reasons of cultural and literary preference as well as to address the intended audience of Chosŏn. The making and remaking of Xingshi yan stories in both China and Korea, this article argues, illuminate the varied knowledge preferences and selections in the forming of the two cultures’ respective literary archives.
Morphogenetic control of zebrafish cardiac looping by Bmp signaling
Authors: Lombardo Verónica A. , Heise Melina , Moghtadaei Motahareh , Bornhorst Dorothee , Männer Jörg , Abdelilah-Seyfried Salim
Published: October 2019

Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. High-resolution 4D live imaging of mosaically-labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire conical cell shapes, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces S-shaping of the heart. During cardiac looping, Bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of Bone morphogenetic protein signalling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This inventory of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects.
Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development inC. elegans
Authors: Horowitz Lauren Bayer , Brandt Julia P. , Ringstad Niels
Published: October 2019

Nervous system development is instructed by genetic programs and refined by distinct mechanisms that couple neural activity to gene expression. How these processes are integrated remains poorly understood. Here, we report that the regulated release of insulin-like peptides (ILPs) during development of the C. elegans nervous system accomplishes such an integration. We find that the p38 MAP kinase PMK-3, which is required for the differentiation of chemosensory BAG neurons, limits an ILP signal that represses expression of a BAG neuron fate. ILPs are released from BAGs themselves in an activity-dependent manner during development, indicating that ILPs constitute an autocrine signal that regulates the differentiation of BAG neurons. Expression of a specialized neuronal fate is, therefore, coordinately regulated by a genetic program that sets levels of ILP expression during development and by neural activity, which regulates ILP release. Autocrine signals of this kind might have general and conserved functions as integrators of deterministic genetic programs with activity-dependent mechanisms during neurodevelopment.
Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients
Authors: Higashikuse Yuta , Mittal Nishant , Arimura Takuro , Yoon Sung Han , Oda Mayumi , Enomoto Hirokazu , Kaneda Ruri , Hattori Fumiyuki , Suzuki Takeshi , Kawakami Atsushi , Gasch Alexander , Furukawa Tetsushi , Labeit Siegfried , Fukuda Keiichi , Kimura Akinori , Makino Shinji
Published: October 2019

Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been found in about half of the patients, while the genetic etiology and pathogenesis remain unknown for many cases of HCM. To identify novel mechanisms underlying HCM pathogenesis, we generated a cardiovascular-mutant medaka fish non-spring heart (nsh), which showed diastolic dysfunction and hypertrophic myocardium. The nsh homozygotes had fewer myofibrils, disrupted sarcomeres and expressed pathologically stiffer titin isoforms. In addition, the nsh heterozygotes showed M-line disassembly that is similar to the pathological changes found in HCM. Positional cloning revealed a missense mutation in an immunoglobulin (Ig) domain located in the M-line-A-band transition zone of titin. Screening of mutations in 96 unrelated patients with familial HCM, who had no previously implicated mutations in known sarcomeric gene candidates, identified two mutations in Ig domains close to the M-line region of titin. In vitro studies revealed that the mutations found in both medaka fish and in familial HCM increased binding of titin to muscle-specific ring finger protein 1 (MURF1) and enhanced titin degradation by ubiquitination. These findings implicate an impaired interaction between titin and MURF1 as a novel mechanism underlying the pathogenesis of HCM.
Investigating the cost-effectiveness of structured diabetes education
Authors: Swift Jim , Barker Chris , Palin Richard , Peck Gill
Published: October 2019

Background/Aims

The National Institute for Health and Care Excellence recommend that people with type 2 diabetes should have access to structured diabetes education. The aim of this study was to evaluate the outcomes and the impact of the EMPOWER T2n structured diabetes education programme.

Methods

Audit data were obtained from 443 participants from four Clinical Commissioning Groups in England. Clinical parameters, including glycated haemoglobin levels and cholesterol, were collected before EMPOWER T2n started, as well as at 6 months into the programme and 14-months after its completion.

Results

There was a statistically significant reduction in glycated haemoglobin at 6-months (−8.2mmol/mol), which was maintained at 14 months (−7.8mmol/mol). Modelled 3-year changes in costs in the base case were -£42.30 for coronary heart disease, -£0.75 for stroke and -£7.79 for microvascular events. The mean number of medicines used decreased from 0.5 at baseline to 0.37 at 14 months (-13.1%). This produced an actual saving of £44.28, with a further saving of £98.78, compared to the modelled increase in medicine use over time. All of these changes translated into an overall gross saving of £193.89 per participant over the 3-year model timeframe. These savings exceeded the average cost of delivering EMPOWER T2n (£96.17 per participant).

Conclusion

Participation in the EMPOWER T2n structured diabetes education programme was associated with improvements against a range of clinical parameters and associated with modelled net cost savings over a 3-year timeframe.
From state uniform to fashion: Japanese adoption of western clothing since the late nineteenth century
Authors: Kobayashi Ami
Published: October 2019

Since the late nineteenth century, yōfuku (a vague Japanese concept referring to all clothing originating from western countries) has spread predominantly from the upper to the lower class and from urban to rural space in Japan. In this process, the symbolic meaning attached to it has been transformed. Once a symbol of male elites, yōfuku has become ‘Japanese fashion’ and is now an expression of current Japanese (pop) culture. This article investigates the adoption process of yōfuku – especially the school uniform, which has reflected the contrasts between elite and non-elite, modernity and tradition, masculinity and femininity, and public duty and private life. Drawing on the case study of Japan, this article also sheds light on the complexity and variety that exist in modernization processes.
Mizrahim masculine fashion as the expression of political confrontation in Israel in the 1970s
Authors: Marzel Shoshana-Rose , Dahan-Kalev Henriette
Published: October 2019

This article explores how and why, in the 1970s, Israeli Mizrahi men – Jews from Arab countries – used fashion (among other tools) to both rebel against Ashkenazim hegemony and reconnect with their own roots. This article first shows how, during Israel’s pre-state era, many Jewish Ashkenazim pioneers wore a very simple outfit that was associated with socialist political ideology and became the male Israeli national dress code before and after Israel’s establishment in 1948. Not all Israelis identified with it, though: in the 1970s, second-generation male Mizrahim rebelled against the ethnic and racial discrimination they suffered from Ashkenazim, and used fashion alongside other means to express their opposition. By doing so, Mizrahim paved the way for contemporary male Israeli fashion. This article clarifies how this fashion change occurred, and how it converged with political upheaval. It also discloses the links with Mizrahim Arabic heritage concerning body care.
Book Review
Authors: Alimen Nazlı
Published: October 2019

Modern Fashion Traditions: Negotiating Tradition and Modernity through Fashion, M. Angela Jansen and Jennifer Craik (eds) (2016) 1st ed., London and New York: Bloomsbury, 256 pp., 23 b/w illustrations ISBN 978 1 47422 949 4, Hardback, UK £90.00; Paperback, UK £28.99; eBook, UK £31.30
Technology and the transmission of tradition: An exploration of the virtual pedagogies in the Online Academy of Irish Music
Authors: Ward Francis
Published: October 2019

The Internet is now a central resource in the transmission of Irish traditional music (ITM), with over 80 per cent of Irish traditional musicians citing that they use online resources. The Online Academy of Irish Music (OAIM) is a website that offers online tuition, and employs innovative virtual pedagogies including Virtual Classrooms, Virtual Sessions, Jam Sessions and Virtual Reality Sessions. Through ethnographic means and focusing on the OAIM as a case study, this article highlights the connection between music and social learning in the ITM tradition. Informed by the work of ethnomusicologists Turino, Rice and Merriam, it documents how the virtual world is attempting to mimic social experiences for the learner of ITM. Documenting this process of mimicking reveals the challenges of holistic online learning, which could prove informative for all stakeholders in the pedagogic process as OAIM endeavours to address the shortcomings and inform the broader investigations into online music education.
Coinfection of Cytomegalovirus and Cryptosporidiosis in a Patient With AIDS
Authors: Conner Michael , Joshi Tejas , Veerisetty Sai Sruthi , Hutchings John
Published: October 2019

Patients with poorly controlled human immunodeficiency virus are subject to a wide range of opportunistic infections. Cryptosporidium is a parasitic gastrointestinal infection associated with chronic and life-threatening diarrhea in patients with acquired immunodeficiency syndrome. Cytomegalovirus colitis is a serious complication caused by reactivation of the virus, leading to viremia and end-organ disease by hematogenous spread. Both diseases can be fatal in less than 4 months. We present an example of a comprehensive investigation in a patient with symptoms that could not be explained in a single diagnosis.
Clinical and cytogenetic correlations in mixed gonadal dysgenesis
Authors: Kasatkina E. P. , Kozlova S. I. , Prytkov A. N. , Tarskaya L. A. , Patyutko R. S. , Lelikova G. P.
Published: October 2019

Clinical-karyotypical correlations have been analyzed in 36 patients with mixed gonadal dysgenesis. The minimal diagnostic signs have been determined: rudimentary uterus, uterine tube, split scrotum, perineal hypospadias, left streak gonad, testicular hypoplasia and scrotal localization of the testicle, and the most incident concomitant abnormalities. A comparative analysis of the distribution of signs in groups with different karyotype disorders has been carried out. The authors discuss the clinical variability of this abnormality on the basis of genetic approaches to the study of mixed gonadal dysgenesis.
Experimental and Clinical Aspects of using luteinizing hormone-releasing factor and its analogs
Authors: Nizharadze I. A.
Published: October 2019

This literature review briefly summarizes the methods of application and the conditions necessary from the physiological point of view to activate the secretion of gonadotropins by the pituitary gland by stimulating the luteinizing hormone-releasing hormone (LH-RH) in a pulsating mode, and we compare the effect of the pituitary stimulating LH-RH- agonists. The structure of LT-RG was explained in 1971 by Matsuo, Baba, in 1972 by F. Burgus, J. Butcher and confirmed in 1971 by the synthesis of Geiger, Konigi Wissmann. Studies conducted over 10 years showed that LG-RG , as well as its analogs are important for clinical practice. There are 2 active groups of agonist analogs. The 1st includes LH-RH analogs with an altered amino acid sequence and is abbreviated Trp "LH-RH. These peptides have a structure very similar to the natural LH-RH. The 2nd group combines LH-RH of 1-9-nano-peptidethylamide agonists. These peptides differ from LH-RG in their C-terminal sequence, Pro9-ethylamide, Leu6 is introduced - LH-RH (l-9-ethylamide), which is abbreviated as Leu6-EA- (1-Trp6), LH-RH (1-9 -ethylamide) - abbreviated as Trp-EA-Z-Ser (Bu +) 6, LH-RH 1-9-ethylamide - l-Ser- (Bu +) 6-EA.
A expressão da subjetividade no contexto da educação inclusiva: complexidade e desafios
Authors: Lustosa Ana Valéria Marques Fortes
Published: October 2019

Na atualidade, a inclusão escolar de pessoas do público alvo da educação especial está presente em todos os níveis de ensino. Essa conquista rompe com séculos de esquecimento, silêncio e omissão no que se refere a esses indivíduos. Apoiada em novas formas de organização do trabalho pedagógico no âmbito da Educação para Todos, evidencia a relevância do processo de aprender como ato iminentemente social, no qual as relações estabelecidas exercem papel fundamental. Nesse contexto, a subjetividade individual e social estão no âmago do processo de aprender em múltiplas e variadas formas, com implicações significativas que se expressam no cotidiano e na vida dos aprendizes, contrapondo-se à visão reducionista que limita o desenvolvimento e a atuação desses indivíduos ao evidenciar a dinâmica dos processos subjetivos como geradores de  possibilidades criativas na superação dos obstáculos.
A ação docente na pós-graduação sob a perspectiva cultural histórica: a criatividade em foco
Authors: Scalise Lara Nassar , Anache Alexandra Ayach
Published: October 2019

Este artigo apresenta reflexões sobre os desdobramentos das estratégias pedagógicas promovidas na ação docente com universitários de um curso de pós-graduação. O foco das discussões foi o desenvolvimento de processos criativos e sua relação com a aprendizagem. A ênfase, nessa discussão, foi dada à subjetividade dos estudantes, no sentido de promoverem novas propostas de engajamento acadêmico. São apresentadas experiências de trabalhos criativos realizados em um curso de pós-graduação stricto sensu, os quais são embasados na Epistemologia Qualitativa e na Teoria da Subjetividade na perspectiva cultural-histórica. Destaca-se, assim, a discussão das produções teóricas que depreendem desse processo, reconhecendo a necessidade de se implantarem propostas de formação profissional que permitam a emergência do professor como sujeito ativo.  Consiste, portanto, em trazer, neste espaço, as reflexões que consideram a criatividade essencial para promover ações e relações que visam superar as práticas reprodutivistas, na educação superior, que reduzem a aprendizagem a atos instrumentais.
O Programa de Extensão Integração UFU/Comunidade (Peic) e suas contribuições ao fazer extensionista da Universidade Federal de Uberlândia
Authors: Amaral Fabíola Dutra , Carvalho Luciana Beatriz de Oliveira Bar de , Betanho Cristiane
Published: October 2019

Este texto tem como objetivo analisar o Programa de Extensão Integração UFU/Comunidade (Peic) entre os anos de 2003 e 2015, no sentido de compreender o seu papel no fazer extensionista e na formação dos discentes dos cursos de licenciatura da Universidade Federal de Uberlândia (UFU), que atuam como bolsistas dos projetos ligados à educação. Neste estudo, de caráter documental, destacamos as mudanças ocorridas nos objetivos do Peic e o crescimento progressivo dos recursos destinados ao programa no período recortado para a pesquisa. Analisando os resultados dos projetos apoiados pelo Programa, percebe-se que a maioria apresenta produção de conhecimento na forma de publicações, indicando o compartilhamento de resultados para fora dos limites dos mesmos. Por outro lado, entende-se que é necessário aprofundar a avaliação dos alunos participantes do Peic, de forma a realimentar o fazer extensionista da UFU.
Atuação do farmacêutico na Atenção Primária em Saúde
Authors: Diel Andressa Caroline Loebens , Cavinatto Aline Wielen , Bisognin Elisiane , Oliveira Karla Renata de
Published: October 2019

A Atenção Primária em Saúde (APS) é desenvolvida por meio da Estratégia Saúde da Família (ESF) a partir do trabalho de uma equipe multiprofissional. No município de Santa Rosa, Rio Grande do Sul, junto à ESF é desenvolvido o Programa de Residência Multiprofissional em Saúde da Família. O objetivo deste trabalho é apresentar as contribuições do farmacêutico na APS, a partir da experiência de duas farmacêuticas. A atuação do farmacêutico na APS acontece por meio do Núcleo de Apoio à Saúde da Família e inclui ações de dispensação de medicamentos e orientação farmacêutica, visitas domiciliares, apoio matricial às equipes de saúde, atendimentos individuais e compartilhados, participação em grupos de saúde interdisciplinares, além da participação na Comissão de Farmácia e Terapêutica. O farmacêutico na APS, além de atuar na gestão do medicamento, auxilia na construção do cuidado da saúde dos usuários, acompanhando seus tratamentos, contribuindo com a equipe na promoção da saúde e qualidade de vida desses sujeitos.
Conversation with Vittorio Gallese about empathy and aesthetic experience
Authors: Gianni Falvo Perla
Published: October 2019

Vittorio Gallese is professor of Psychobiology at the University of Parma, Italy, and was professor in Experimental Aesthetics at the University of London, UK (2016-2018). He is an expert in neurophysiology, cognitive neuroscience, social neuroscience, and philosophy of mind. Gallese is one of the discoverers of mirror neurons. Gallese has been doing research at the University of Lausanne, Switzerland, at the Nihon University, Tokyo, Japan, at the University of California at Berkeley and at the Berlin School of Mind and Brain of the Humboldt University of Berlin. He has been George Miller visiting professor at the University of California at Berkeley. His research attempts to elucidate the functional organization of brain mechanisms underlying social cognition, including action understanding, empathy, language, mindreading and aesthetic experience.
Production of phosphorus biofertilizer based on the renewable materials in large laboratory scale
Authors: Wyciszkiewicz Małgorzata , Sojka Marcin , Saeid Agnieszka
Published: October 2019

This paper discusses the effect of the utilization of Bacillus megaterium in the microbial solubilization process where poultry bones or ash were used as a source of renewable phosphorus. The process was performed in a large scale laboratory. The pH of the solution decreased during one-week solubilization, which had a direct influence on the increased concentration of phosphorus determined in the solution. It was proved that the phosphorus concentration in the solution was significantly correlated with the biomass concentration and pH. The trial allowed verification of the suitability of the method to prepare two P fertilizers: one based on poultry bones and one on ashes. The elemental analysis of their composition suggests that the bones are a P-bearing resource with properties better than ash. That enables for more efficient scaling-up the solubilization although the concentration of total phosphorus was comparable in both cases. The total amount (100%) of phosphorus was present in a form available to plants in the formulation based on the poultry bones, while 64% of plant available phosphorus was present in the formulation based on the ash. The concentration of Cd was significantly lower in the case of fertilizer based on bones with respect to ash.
Is Primary Care A Substitute or Complement for Other Medical Care? Evidence from Medicaid
Authors: Chen Jiajia , van den Berghe Eunkyung , Kaestner Robert
Published: October 2019

It is widely believed that Medicaid reimbursement for primary care is too low and that these low fees adversely affect access to healthcare for Medicaid recipients. In this article, we exploit changes in Medicaid physician fees for primary care to study the response of primary care visits and services that are complements/substitutes with primary care, including emergency department, hospitalization, prescription drugs, and imaging. Results from our study indicate that higher Medicaid fees for primary care have modest effects. Among non-blind and non-disabled adults, we find that a 25% (or $10) increase in Medicaid fees for primary care is associated with approximately a 5% of a standard deviation increase in the number of primary care visits. For the same group, we also find that the fee increase is associated with an increase in the probability of having any primary care visits of approximately 3 percentage points. For children, changes in Medicaid fees are not significantly related to the number of primary care visits. In terms of other types of care, we find some evidence that Medicaid fees for primary care are associated with prescription drug use, and no evidence that primary care fees are associated with the use of emergency department, inpatient services, or imaging. Overall, our evidence provides, at best, limited support for the large effects of Medicaid fees on service provision sometimes asserted in policy discussions.
Gas-solid Flow Behaviors in a Pressurized Multi-stage Circulating Fluidized Bed with Geldart Group B Particles
Authors: Nie Wei , Feng Rongtao , Li Junguo , Hao Zhenhua , Zhan Haijuan , Cheng Zhonghu , Fang Yitian
Published: October 2019

A comprehensive study of gas-solids flow behaviors was conducted in a novel multi-stage circulating fluidized bed (MCFB). Experiments were carried out in a cold model apparatus (a jetting fluidized bed, JFB, of 0.3 m diameter and 1.95 m tall, a riser of 0.15 m diameter and 12 m tall) at different elevated pressure, solids circulation rates and gas velocities. Geldart group B polystyrene particles of 400 μm in diameter and 1020 kg/m3 in density were used as bed materials. The characteristic of L-valve, axial and radial distributions of solids holdup were systematically tested at elevated pressures by pressure transducers with the frequency of 100 Hz and model PC6M of the optical fiber probes. Operating the L-valve at elevated pressure needs less cross-section average gas velocity compared to that at atmospheric pressure. Experimental results showed that under elevated pressure and high solids flow rate, the MCFB could more easily couple JFB with a riser, where the solids that entered could form three-level step-by-step supplement entrainment and multi-flow regimes formed. Besides, increasing operating pressure led to a higher the apparent solids holdup and local solids holdup. The local solids profiles behaved less uniform distribution at elevated pressure due to decreasing the gas velocity.
Synthesis and crystal structure of bis{2-bromo-6-(((4-(1-(methoxyimino)ethyl)phenyl)imino)methyl)phenolato-κ2
N,O}cobalt(II)–dichloromethane(1/1), C34H32Br2Cl4CoN4O4
Authors: Fu Tao , Ma Jin-Xia , Wei Ping , Li Qing-Lin , Zhao Ji-Xing , Zhao Li
Published: October 2019

C34H32Br2Cl4CoN4O4, monoclinic, C2/c (no. 15), a = 30.281(3) Å, b = 8.9971(8) Å, c = 13.9050(13) Å, β = 107.053(5)°, Z = 4, V = 3621.7(6) Å3, R
gt(F) = 0.0648, wR
ref(F
2) = 0.1629, T = 173(2) K.
Crystal structure of catena-poly[triaqua-(1,3-di(1H-imidazol-1-yl)benzene-κ2
N:N′)-(3-nitrophthalato-κ1
O)cobalt(II)] — water (2/3), C20H22N5O10.5Co
Authors: Yin Wei-Dong , Liu Qian-Long , Li Gui-Lian
Published: October 2019

C20H22N5O10.5Co, triclinic, P1̄ (no. 2), a = 7.9667(3) Å, b = 11.5847(4) Å, c = 13.5305(5) Å, α = 81.096(3)°, β = 83.110(3)°, γ = 69.997(4)°, V = 1156.26(8) Å3, Z = 2, R
gt(F) = 0.0439, wR
ref(F
2) = 0.1096, T = 292(1) K.
Crystal structure of 4-benzyl-1-oxo-N-phenethyl-1H-[1,4]oxazino [4,3-b]indazole-3-carboxamide, C26H21N3O3
Authors: Wei Xian , Li Ying Fen , Xu You Lin , Lv Meng Lan
Published: October 2019

C26H21N3O3, triclinic, P1̄ (no. 2), a = 9.149(4) Å, b = 9.249(4) Å, c = 13.508(7) Å, α = 91.995(9)°, β = 101.158(8)°, γ = 108.392(8)°, V = 1058.5(9) Å3, Z = 2, R
gt(F) = 0.0628, wR
ref(F
2) = 0.1668, T = 296(2) K.
The crystal structure of bis(imidazole-1-yl)methane monohydrate, C7H10N4O
Authors: Wang Yong , Yuan Jun , Cao Duanlin , Wang Jianlong , Chen Lizhen
Published: October 2019

C7H10N4O, monoclinic, I2 (no. 5), a = 15.7815(13) Å, b = 4.3242(3) Å, c = 12.4658(9) Å, β = 106.301(8)°, V = 816.50(10) Å3, Z = 4, R
gt(F) = 0.0473, wR
ref(F
2) = 0.1067, T = 113.25(10) K.
The crystal structure of bis(4-nitroimidazole-1-1yl)methane, C7H6N6O4
Authors: Yong Wang , Jun Yuan , Duanlin Cao , Jianlong Wang , Lizhen Chen
Published: October 2019

C7H6N6O4, monoclinic, P21/c (no. 14), a = 21.0402(7) Å, b = 7.9959(3) Å, c = 11.8012(4) Å, β = 102.379(1)°, V = 1939.22(12) Å3, Z = 8, R
gt(F) = 0.0481, wR
ref(F
2) = 0.1296, T = 170 K.
Crystal structure of a low-temperature (100 K) polymorph of catena-poly[(μ2-4,4′-bipyridine-κ2
N,N′)-bis(O,O′-diethyldithiophosphato-κ1
S)zinc(II)], C18H28N2O4P2S4Zn
Authors: Tan Yee Seng , Tiekink Edward R.T.
Published: October 2019

C18H28N2O4P2S4Zn, triclinic, P1̄ (no. 2), a = 15.2379(1) Å, b = 17.3322(2) Å, c = 21.8829(1) Å, α = 75.919(1)°, β = 78.050(1)°, γ = 68.170(1)°, V = 5159.97(8) Å3, Z = 8, R
gt(F) = 0.0246, wR
ref(F
2) = 0.0681, T = 100 K.
Crystal structure of dichlorido-(N′-(1-(3-ethylpyrazin-2-yl)ethylidene)-4-methoxybenzohydrazide-κ3
N,N′,O)cadmium(II), C16H18N4O2Cl2Cd
Authors: Duan Wei-Guo , Guo Yi-Peng , Lin Long , Wu Wei-Na
Published: October 2019

C16H18N4O2Cl2Cd, monoclinic, P21/n (no. 14), a = 9.833(2) Å, b = 17.404(4) Å, c = 11.694(3) Å, β = 112.901(3)°, V = 1843.5(8) Å3, Z = 4, R
gt(F) = 0.0280, wR
ref(F
2) = 0.0728, T = 296(2) K.
Entropy generation in an inclined porous channel with suction/injection
Authors: Jha Basant K. , Yusuf Taiwo S.
Published: October 2019

The present work is concerned with an analytical study of entropy generation in viscous, incompressible fluid in an inclined channel with porous walls. The solution of the governing equations were obtained in closed form. The expression for the irreversibility ratio was also obtained and the results were presented graphically and extensively discussed for different values of the dimensionless parameters. The result indicates that wall inclination enhance entropy generation.
Targeting 5α-reductase with 99mTc labeled dutasteride derivatives for prostate imaging
Authors: Gul-e-Raana  , Shah Syed Qaiser
Published: October 2019

To assess the suitability of 99mTc labeled 5α-reductase (5α-Rds) inhibitors for non-invasive targeting of prostate cancer (PCa) using Male Sprague Dawely Rat (MSDR) model. In this work, dutasteride (Cpd-1) a 5α-Rds inhibitor was derivatized to its dithiocarbamate analogue (Cpd-2) for subsequent synthesis of 99mTc(CO)3-dutasteride dithiocarbamate (Cpd-3) using tricarbonyl technique. To determine the structure of Cpd-3, for the first time a reference Re(CO)3-dutasteride dithiocarbamate (Cpd-4) was synthesized and characterized with NMR, ESIMS, HPLC and elemental analysis. HPLC was used to establish the identity of Cpd-3 using Cpd-4 as a reference standard. The suitability of Cpd-3 as a new 5α-Rds targeting agent was investigated, both in vitro and vivo. The Cpd-3 has shown ≥98 % in vitro stability at room temperature and was remained ≥90 % stable up to 6 h. In serum Cpd-3 has revealed an analogous behavior with a small decrease in stability after 16 h. High uptake (26.25 ± 1.10 %, after 4 h of i.v.) of Cpd-3 was observed in the prostate (target tissue) of MSDR model with reasonably good target to non-target ratio. Blocking the target site with excess Cpd-2 considerably decreased the uptake of Cpd-3 to 4.10 ± 0.75 % in PCa. High in vitro stability in saline and serum and in vivo uptake in prostate of MSDR model plausibly attracts the opportunity of using Cpd-3 as a novel radiopharmaceutical for non invasive targeting of prostate.
Validation of an analytical method to quantify serum electrolytes by atomic absorption spectroscopy
Authors: García-Alegría Alejandro Monserrat , Gómez-Álvarez Agustín , García-Rico Leticia , Serna-Félix Mercedes
Published: October 2019

The objective of this research was to develop the procedure to validate an analytical method through the technique of spectroscopy by atomic absorption to quantify serum electrolytes. Quality parameters were used such as: accuracy, precision, repeatability, linearity, limit of detection, and limit of quantification. First some work was done in optimization of the analytical method in ideal conditions. Subsequently, some work was done with the validation of the method using a certified reference material National Institute Standard Technology (NIST) 2670a. Finally, the methodology was assessed in the determination of metals in a sample of human blood serum. The quality criteria evaluated showed consistent and acceptable values depending on the statistical test used for each parameter with a significance level of 5%  (α = 0.05). The results obtained in this research can contribute to the beginning of the establishment of an official standard aimed at analysis of electrolytes (Na, K, Ca, Mg) in human blood serum so that can be used as reference by clinical laboratories, public health institutions, as well as in institutions of higher education and research centers.
Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3
Authors: Calderón Guzmán David , Attilus Jonas , Juárez Olguín Hugo , Hernández García Ernestina , Osnaya Brizuela Norma , Ortiz Herrera Maribel , Barragán Mejía Gerardo
Published: October 2019

Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients exposed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluorescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism.
Risk behavior perception in university students of the health area
Authors: Reynaga-Ornelas Ma. Guadalupe , Fernández-Carrasco María del Pilar , Muñoz-Canul Ileana del Carmen , Vera-Becerra Luz Elvia
Published: October 2019

Risk behaviors associated with life style may deliver in students´ health risk. Therefore, our objective is to describe health risk behaviors perceived by health area university students. For this a 14 item survey about risk behaviors related to physical activity practice, food consumption, drug use, stress level and sleep habits was applied in the health area students. 995 students were interviewed. Most were women (69%) with 20.1 + 1.8 years old. Of these women surveyed, twenty nine percent report no physical activity. Fifty one percent eat 5 fruit and vegetables 4 times/week or more. Only 30% drinks 2 L of water/day. Eighty two percent don’t smoke, 55% don’t drink alcohol and 90% don’t use drugs. Twelve percent reports to be on stress always and 72% sleep more than 7 hours/day only 3 times/week or less. This work concluded that university students of the Health Area don´t have the healthy life style that’s expected.
Variabilidad genética del membrillo cimarrón (Malacomeles denticulata [Kunth] Jones) obtenida mediante marcadores Inter Secuencias Simples Repetidas o Intermicrosatélites (ISSR)
Authors: González-Cerritos Daniela , Núñez-Colín Carlos Alberto , Villordo-Pineda Emiliano , Medina-Ramos Gabriela , González-Chavira Mario Martín
Published: October 2019

Malacomeles denticulata es un fruto nativo de México al que recientemente se le ha encontrado características funcionales para proponerlo como una opción frutal. Esta investigación tuvo como objetivo elucidar la variabilidad de doce poblaciones de M. denticulata mediante marcadores Inter Secuencias Simples Repetidas o Intermicrosatélites (ISSR). Todos los ISSR presentaron altos valores en el Contenido de Información Polimórfica (PIC, por sus siglas en inglés) y el índice de diferenciación poblacional de Nei (GST), así como altos porcentajes de polimorfismo. Se crearon tres grupos de variabilidad, donde siete poblaciones de Guanajuato y la población del Tepozán, Querétaro, conformaron un grupo; mientras que las poblaciones de Agua Zarca (Guanajuato), La Joya (Querétaro) y Santa Catarina del Monte (México) conformaron otro. Finalmente, la población de San Miguel Tlaixpan (México) quedó separada como un grupo atípico. De acuerdo con el Análisis Molecular de Varianza (Amova), la variabilidad intrapoblacional representa el 47% y la interpoblacional el 53% de la variabilidad total, lo que concuerda con la variabilidad en caracteres de semilla, pero difiere a lo reportado para marcadores SSR.
La cohesión social y los límites de los hogares en México (2008-2012)
Authors: Aboites Gilberto , Sánchez Araceli , Minor Campa Enrique
Published: October 2019

Este trabajo analizará la relación entre la cohesión social y los hogares en México. El tema surgió a partir de lo establecido en la Ley General de Desarrollo Social (LGDS), artículo 36, referido a medir la pobreza de manera multidimensional, incluyendo el grado de cohesión social. Esta situación obligó al Consejo Nacional de Evaluación de la Política de Desarrollo Social (Coneval) a trabajar sobre el tema, para lo cual se han utilizado indicadores de percepción de las redes sociales, construidos con base en la Encuesta Nacional de Ingreso Gasto de los Hogar (2008-2012). De acuerdo con la información disponible, se desprende que la familia/hogar está sometida a fuertes presiones sociales, dado lo cual la politica social no debe descanzar primordialmente en el accionar del hogar/familia. Diversos estudios etnográficos documentan el proceso de erosión del tejido social ante las amenazas que la pobreza y la inseguridad del empleo imponen, pues limitan la reciprocidad y las relaciones sociales horizontales, propias de los sistemas de ayuda mutua, y hay cada vez más evidencias de que la pobreza está acompañada de situaciones de aislamiento y mayor segregación social. Fallas en la reciprocidad social ocasionan o se asocian con una disminución de la interacción, situación que se ilustra con una mayor propensión hacia las familias nucleares en lugar de extensas. Sin embargo, esa manera de interpretar supone una lógica social más propia del homo econmicus y menos del homo socialis, dado que predomina un criterio de racionalidad esencialmente condicional y orientado al futuro.