bluuebunny/crossref_metadata_2025 huggingface dataset:
Penulisan Karya Ilmiah Guru yang Berpotensi Hak Cipta dalam Upaya Menunjang Kompetensi Guru-Guru SMPN 32 Bekasi
Authors: Purwaningsih Endang , Ariyanti Evie Rachmawati Nur , Santosa Irwan
Published: January 2023

Tujuan pengabdian ini adalah untuk meningkatkan pemahaman dan kompetensi guru-guru SMP N 32 Bekasi dalam penulisan karya ilmiah guru yang berpotensi hak cipta. Metode yang digunakan adalah ceramah, diskusi dan pelatihan tentang (1) edukasi dan pelatihan penulisan karya ilmiah yang berpotensi hak cipta; dan (2) penyuluhan hukum tentang HKI khususnya Hak Cipta agar menambah pengetahuan dan motivasi para guru SMPN 32. Jumlah khalayak sasaran sebanyak 41 orang (89%) dari jumlah total guru sebanyak 46 orang. Berdasarkan hasil analisis data pre-test dan post-test diperoleh hasil: terjadi peningkatan: a) pemahaman cara membuat karya ilmiah sebesar 9,7%, b) pemahaman objek hak cipta dan sistem perlindungannya sebesar 21,9%, c) pemahaman responden akan pentingnya publikasi karya ilmiah sebesar 7,3%, d) pemahaman responden akan cara mencatatkan hasil ciptaan sebagai hak cipta sebesar 31,7%, e) pemahaman responden akan istilah ciptaan, pencipta, pemegang hak cipta dan peralihan hak cipta sebesar 21,9%, dan f) keinginan responden dalam hal pemilihan hak cipta sebesar 4,8%). Tingkat kenaikan tertinggi yaitu pada aspek Pemahaman responden akan cara mencatatkan hasil ciptaan sebagai hak cipta sebesar 31,7%, disusul aspek Pemahaman objek hak cipta dan sistem perlindungannya dan Pemahaman responden akan istilah ciptaan, pencipta, pemegang hak cipta dan peralihan hak cipta masing-masing sebesar 21,9%. Kenaikan terendah yaitu pada aspek Keinginan responden dalam hal pemilihan hak cipta yang hanya sebesar 4,8%. Dengan demikian, rata-rata kenaikan sebesar 15,01%.
Kolaborasi Penanganan Masalah Siswa Melalui Kemitraan antara Pusat Pelayanan Keluarga Sejahtera Universitas YARSI dan Guru Bimbingan Konseling di Jakarta Pusat
Authors: Ranakusuma Octaviani Indrasari , Trisiswati Maya , Utami Sri Puji
Published: January 2023

Selama masa pandemik, siswa melakukan pembelajaran secara daring (online). Kesempatan untuk tatap muka bergaul bersama teman-teman sebaya, bertemu dan mengenal para guru menjadi sangat terbatas padahal masa remaja merupakan masa transisi menuju masa dewasa dengan tuntutan yang semakin bertambah. Dengan kemampuan kognitif yang semakin berkembang, remaja memiliki kesempatan untuk mengeksplorasi kemampuan dirinya sebagai upaya mengembangkan identitas diri termasuk dalam merancang masa depan. Kondisi pandemik menyulitkan Guru BK untuk memantau kondisi siswa termasuk kondisi kesehatan jiwanya, kecuali bila menimbulkan masalah akademik (misal: tidak masuk sekolah, nilai yang buruk). Program komunikasi, informasi dan edukasi (KIE) yang dilakukan PPKS meningkatkan pengetahuan Guru BK dalam mendeteksi masalah kesehatan jiwa remaja sejak dini dan untuk mengenali bakat dan minat remaja. Aplikasi sistem perencanaan karir (SICAKAR) dan aplikasi kesehatan jiwa GALAW yang dikembangkan oleh Universitas YARSI juga disosialisasikan untuk membantu memantau kondisi siswa secara daring.
Pemberdayaan Masyarakat Desa Bantarsari dalam Meningkatkan Kualitas Monitoring Perkembangan Gizi Bayi
Authors: Yugaswara Heri , Suhaeri Suhaeri , Wuryanti Sri , Nurmaya Nurmaya
Published: January 2023

Pelaksanaan kegiatan pengabdian pada masyarakat di Desa Bantarsari Kabupaten Bogor bertujuan untuk memberdayakan warga Desa Bantarsari khususnya kader posyandu dalam meningkatkan kualitas pemantauan gizi balita. Adapun kegiatan yang diberikan adalah pelatihan penggunaan aplikasi Smart Posyandu. Aplikasi dibuat berdasarkan kebutuhan dari mitra yaitu Posyandu Bantarsari. Evaluasi kegiatan dilakukan dengan memberikan kuesioner terdiri dari 13 pertanyaan yang tersebar ke lima variabel. Hasil evaluasi menunjukkan bahwa aplikasi Smart Posyandu dapat membantu pekerjaan para peserta dalam meningkatkan kualitas pemantauan gizi balita serta mudah digunakan. Para peserta juga termotivasi untuk menggunakan aplikasi Smart Posyandu. Secara keseluruhan para peserta merasa puas atas kegiatan pelatihan yang diberikan.
Pelatihan Pembuatan Vlog dan Video Editing untuk Pelajar di Ciracas
Authors: Utami Sri Puji , Rachmawati Ummi Azizah
Published: January 2023

Tujuan dari kegiatan P2M ini adalah memberikan pelatihan Vlog dan video editing pada pelajar di daerah Ciracas dan sekitarnya. Pandemik Covid-19 telah menjadikan pelaksanaan P2M ini dilaksanakan secara daring dan diikuti oleh peserta yang di luar dari rencana semula. Kegiatan yang dilakukan adalah berupa pemberian materi tentang vlog, tentang tahapan tahapan yang perlu diperhatikan dalam membangun vlog, serta batasan batasan yang perlu diperhatikan. Setelah itu dilakukan pelatihan video editing untuk dapatmembuat vlog yang bagus. Sasaran kegiatan ini adalah pelajar, mahasiswa dan umum. Manfaat kegiatan ini adalah peserta mendapatkan pengetahuan tentang vlog serta mendapatkan kemampuan untuk mengedit video menggunakan DaVinci Resolve.
Pengetahuan Guru-Guru SMPN 32 Bekasi Terhadap Pentingnya Akta Autentik dalam Transaksi Tanah
Authors: Purwaningsih Endang , Santosa Irwan , Ariyanti Evie Rachmawati Nur
Published: January 2023

Tujuan pengabdian kepada masyarakat yang dilakukan terhadap guru-guru SMP N 32 Bekasi adalah untuk meningkatkan pemahaman dan literasi pentingnya akta autentik dalam transaksi jual beli tanah, sehingga terbangun kesadaran hukum dalam transaksi pertanahan, yang kemudian dapat ditularkan pengetahuannya kepada peserta didik dan masyarakat sekitar, sekaligus memahami faktor kendala dan pendukung kesadaran hukumnya agar dapat dicarikan solusinya. Kegiatan ini dilaksanakan dengan menggunakan metode ceramah dan diskusi. Tahap awal dilakukan pre-test untuk mengungkap pengetahuan para guru secara brainstorming, kemudian dilakukan intervensi berupa pembekalan materi dengan cara sosialisasi dan edukasi, dengan metode ceramah dan diskusi. Selanjutnya dilakukan post-test, untuk mengetahui apakah materi benar-benar terserap dan dipahami oleh para guru. Hasil pengabdian kepada masyarakat yang telah dilakukan dalam bentuk penyuluhan hukum dapat meningkatkan pengetahuan dan kesadaran hukum para guru akan pentingnya akta autentik dalam transaksi jual beli tanah. Pada aspek pentingnya akta autentik dalam transaksi jual beli tanah guna lebih menjamin kepastian hukum dalam pembuktian kepemilikan terjadi peningkatan 12,5%. Peningkatan aspek perbedaan antara akta autentik dan akta di bawah tangan sebesar 20%. Peningkatan aspek pemahaman PPJB dan AJB sebesar 27,5%. Peningkatan aspek syarat sahnya perjanjian dalam transaksi tanah dan alur prosesnya hingga peralihan hak milik sebesar 27,5%. Peningkatan aspek perbedaan tugas Notaris dan PPAT yaitu sebesar 25%. Faktor pendukung dan penghambat tumbuhnya kesadaran hukum guru terhadap pentingnya pembuatan akta autentik terkait transaksi tanah adalah motivasi yang baik, namun kurang akses informasi dan sosialisasi serta edukasi dari para pembuat kebijakan maupun pihak yang peduli seperti kampus.
Edukasi Pencegahan Penyakit Covid-19 Melalui Penyuluhan Etika Batuk dan Bersin, Serta Pemakaian Masker yang Benar di RPTRA Kelurahan Sumur Batu, Jakarta Pusat
Authors: Ferlianti Rika , Zulhamidah Yenni , Bahri Syukrini
Published: January 2023

Pada mekanisme pertahanan tubuh yang alami, batuk dan bersin merupakan refleks normal tubuh yang berfungsi untuk membersihkan lendir ataupun benda asing yang masuk ke saluran pernapasan. Berbagai jenis penyakit saluran pernapasan dapat menular lewat batuk maupun bersin, karena kuman dapat menyebar melalui droplet maupun rute airborne antara lain influenza, cacar air, campak, tuberkulosis, SARS, pertusis, Ebola, dan yang terbaru dan menjadi pandemi sampai saat ini adalah Covid-19. Covid-19 (Coronavirus Disease 2019) adalah penyakit yang dapat menyebabkan gangguan pernapasan dan radang paru. Penyakit ini disebabkan oleh infeksi Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Dan salah satu pencegahan yang dilakukan adalah menggunakan masker yang benar, selain mencuci tangan dan menjaga jarak. Kegiatan ini bertujuan menjelaskan etika batuk dan bersin, menggunakan dan melepas masker yang benar dan pengetahuan tentang penyakit Covid-19 kepada masyarakat di Kelurahan Sumur Batu. Metode yang dilakukan pada kegiatan ini adalah penyuluhan dan pemutaran video edukasi yang dilakukan secara daring melalui media Zoom dan TV Yarsi. Jumlah responden yang ikut adalah sebanyak 24 orang. Hasil kegiatan menunjukkan terjadi peningkatan 82% pada responden mengenai pengetahuan tentang etika batuk dan bersin, pemakaian dan pelepasan masker yang benar serta pengetahuan mengenai penyakit Covid 19 pada masyarakat di sekitar RPTRA Kelurahan Sumur Batu.
Edukasi Deteksi Awal Penyakit Jantung Koroner dengan WHO/ISH Prediction Charts Pada Kader Kecamatan Cempaka Baru, Jakarta Pusat
Authors: Mukhtar Diniwati , Fitriani Hasna Luthfiah , Qomariyah Qomariyah , Ridwan Karina Ajeng
Published: January 2023

Menurut Riskesdas tahun 2018 prevalensi tertinggi penyakit jantung koroner di Pulau Jawa adalah di DKI Jakarta (1,9%). Penyakit jantung koroner merupakan penyebab utama morbiditas dan mortalitas serta bertanggung jawab atas sepertiga kejadian dari seluruh kematian di Indonesia, yakni sebesar 26,4%. Berdasarkan penelitian tim YARSI sebelumnya di Kecamatan Cempaka Baru Jakarta Pusat, didapatkan bahwa daerah tersebut merupakan kluster penyakit jantung koroner yang cukup tinggi dan belum pernah mengadakan pelatihan terhadap kader untuk melakukan deteksi awal risiko penyakit jantung koroner dengan menggunakan WHO/ISH Cardiovascular Risk Prediction Charts. Memberikan edukasi tentang deteksi awal penyakit jantung koroner dengan WHO/ISH prediction charts pada kader kecamatan Cempaka Baru, Jakarta Pusat. Metode yang dilakukan berupa pemberian edukasi menggunakan slide Powerpoint dengan instrumen kuesioner pre-test dan post-test. Setelah penyuluhan dilakukan pemeriksaan tekanan darah, gula darah sewaktu dan kolesterol total. Pemberian edukasi dilaksanakan selama satu hari pada hari Selasa, 07 Desember 2021, pukul 09.00 – 12.00 WIB dalam bentuk seminar penyuluhan. Evaluasi yang dilakukan dengan membandingkan hasil pre-test dan post-test menunjukkan bahwa tingkat pengetahuan meningkat signifikan dari uji Wilcoxon dengan nilai p = 0,000 (p<0,05). Pemberian edukasi telah meningkatkan pengetahuan secara signifikan dan penyuluhan ini diharapkan dapat menurunkan risiko mortalitas dan morbiditas penyakit jantung koroner di kemudian hari serta peran masyarakat dalam mencegahan faktor risiko penyakit jantung koroner.
Towards learning healthcare systems
Authors:   , Vermond Debbie
Published: January 2023

The complex balance between scientific evidence, clinical expertise and the patient’s experience makes healthcare systems prone to inefficiency and fragmentation. This sparks the interest into a care system that aligns the input from researchers providing scientific evidence, healthcare professionals building their clinical expertise on that, and patients experiencing outcomes: a Learning Healthcare System (LHS). Yet, to build such a system requires insight into the role of, and interplay between, researchers, healthcare professionals and patients.

In the first part of this thesis, we zoom in on the role of researchers. Using a Social Network Analysis (SNA) perspective, we explore with whom they collaborate, how, and why. The second part of this thesis focuses on the role of healthcare professionals and patients. We assess how the process of collaboration between them unfolds from a Cultural Historical Activity Theory (CHAT) perspective.

We conclude that combining different units of analysis (researchers, healthcare professionals and patients) and theoretical frameworks (e.g. SNA and CHAT) is necessary to understand and develop a complex system as the LHS. We should increasingly think in, design and invest in healthcare networks and research communities – and, essentially, include herein the patient perspective as one on which developments and changes are based.
Improving blood-induced joint damage in haemophilia:
from early detection to early treatment
Authors:   , van Bergen Eline Dorothea Petronella
Published: January 2023

The inherited coagulation disorder haemophilia is characterized by spontaneous and trauma-related bleeding. Recurrent joint bleeds leading to synovial inflammation and osteochondral damage cause major morbidity amongst patients with haemophilia. The current treatment strategy focuses on preventing joint bleeds and subsequent haemophilic arthropathy. Although prophylactic clotting factor replacement therapy has led to a significant decrease in joint bleeds, (subclinical) bleeding can not be prevented completely. The early detection and early initiation and adaptation of treatment is of utmost importance to prevent (irreversible) progression of arthropathy. This thesis aimed to provide a broader insight in the abilities of early detection and early treatment of haemophilic arthropathy.
The early detection part focused on the occurrence and detection of subclinical joint changes by imaging and biochemical markers. The occurrence of subclinical blood-related and inflammatory joint changes in the six major synovial joints (ankles, knees, elbows) was evaluated by ultrasound in a cross-sectional study including patients without recent joint bleeds or complaints. Two systematic reviews were conducted to identify biochemical markers sensitive to joint changes in haemophilia and promising biochemical markers were selected and evaluated in the cross-sectional study. Besides, a subset of patients with lifelong access to prophylaxis and a joint without a history of bleeding, was also evaluated for signs of previous subclinical bleeding on magnetic resonance imaging (MRI). The early treatment part focused on treatment modalities that can prevent further joint damage and subsequent major orthopaedic interventions. As a first step, the safety regarding adverse bleeding and cardiovascular events in patients with haemophilia using (non-) selective non-steroidal anti-inflammatory drugs (NSAIDs) was systematically summarized. Next, a prospective pilot study was conducted investigating the clinical and structural changes after ankle joint distraction (AJD).
PENERAPAN MODEL PEMBELAJARAN ROLE PLAYING UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA TEMA VIII KELAS SD NEGERI 060934 MEDAN
Authors: Sinaga Yuni  Sinaga Rayanti , Sinaga Reflina , Marianus Sumarlin Mangandar , Tanjung Darinda Sofia
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa dengan menerapkan model pembelajaran Role Playing  pada Tema Daerah Tempat Tinggalku di kelas IV SD Negeri 060934 Kec. Medan Johor Tahun Pembelajaran 2021/2022. Subjek penelitian seluruh siswa kelas IV yang terdiri dari 11 siswa perempuan dan 11 siswa lai-laki. Teknik pengumpulan data yang digunakan yaitu observasi dan tes. Hasil penelitian menunjukkan adanya peningkatan hasil belajar siswa pada Tema Daerah Tempat Tinggalku. Hal ini terbukti dari hasil pretest terdapat 4 siswa yang tuntas (18,18%) sedangkan 18 siswa (81,82%) tidak tuntas dengan rata-rata sebesar 53. Pada postes siklus I terjadi peningkatan dengan 8 siswa (36,36%) yang tuntas dan 14 siswa yang tidak tuntas (63,64% ) yang tidak tuntas dengan rata-rata sebesar 66,3. Pada postes siklus II hasil belajar siswa meningkat terdapat 18 siswa (81,82%) yang tuntas dan 4 siswa yang tidak tuntas (18,18% ) tidak tuntas, dengan rata-rata 84,4. Selanjutnya hasil observasi aktivitas guru dalam pembelajaran siklus I diperoleh nilai rata-rata 48% dan observasi siswa 62%. PSiklus II hasil observasi guru meningkat menjadi 82% dan hasil observasi kegiatan siswa juga meningkat menjadi 88. Dangan demikian penggunaan model pembelajaran model role playing dapat meningkatan hasil belajar siswa pada tema daerah tempat tinggalku di kelas IV SD Negeri 060934 Kec. Medan Johor.
The World Turned Upside Down, Again: Hauntings of the English Revolution and Archaeologies of Futures Past in Contemporary British Films
Authors: Schmitt Mark
Published: January 2023

In the 1960s and 1970s, the period of the Civil War and the English Revolution featured prominently in a variety of films ranging from the mainstream historical drama Cromwell to the independent Winstanley and the folk horror film Witchfinder General. Film-makers’ interest in the period at that time coincided with the cultural, social and political turmoil of 1968 as well as with the increasingly popularised revision of the period in Marxist historiography, such as Christopher Hill’s seminal book The World Turned Upside Down. Recently, there has been a renewed interest of British film-makers in Hill’s focus on the subcultures of the English Revolution, such as the Diggers, as well as in the aesthetics of earlier films about the period. This article analyses two contemporary films about the period, Ben Wheatley’s A Field in England and Thomas Clay’s Fanny Lye Deliver’d, and through historicisation and contextualisation within film, genre and media history seeks to understand the significance of their return to the historical material of the seventeenth century as well as to the style of their filmic models from the 1960s and 1970s. The article argues that the two films perform an ‘archaeology of the future’ (Jameson) that excavates utopian ‘futures past’ (Koselleck) in British cultural history as well as in British film and media history. By analysing Wheatley and Clay’s films as hauntological and archaeological texts, the article explores the potential of the cinematic image for engaging with national and film history as well as with visions of the past and the future.
Kur’ân’da İlâhî Otoriteyi İfade Eden İsimler (Esmâ-i Hüsnâ Rivâyeti Özelinde)
Authors: Özaktan Fatih
Published: January 2023

Kur’ân’da ve hadislerde Allah Teâlâ’yı tanıtan isim, sıfat ve terkipler yer almaktadır. Kur’ân’da Allah’ı tanıtan isimlere dört âyette esmâ-i hüsnâ terkibi ile dikkat çekilmiştir. Bu isimler, farklı sûre ve âyetlerde bulunmakla birlikte İbn Mâce ve Tirmizî’nin naklettiği esmâ-i hüsnâ rivâyetinde bir arada zikredilmiştir. Bu çalışmada Kur’ân’da geçen, diğer taraftan İbn Mâce ve Tirmizî’nin listesinde yer alan ve doğrudan ilâhî otoriteyi ifade eden isimler ele alınmış, Allah’ın otoritesi ile doğrudan irtibatı olmayan isimlere yer verilmemiştir. Kur’ân’da pek çok yerde tevhîd, nübüvvet ve âhiret konuları işlenirken yönetmenin sadece Allah’a ait olduğu vurgulanmaktadır. Bu nedenle özellikle tevhîd inancı açısından ilâhî otoriteye dikkat çeken isimlerin tespit ve tahlili önemlidir. Bu amaçla yapılan bu çalışmada, esmâ-i hüsnâ rivâyetinde ilâhî otoriteyi ifade eden isimleri kategorize etmek, isimlerin içinde geçtiği âyetle olan irtibatını, uyumunu ve cümleye kattığı anlamı tespit etmek hedeflenmiştir. Bu gaye doğrultusunda ilâhî otorite ile ilgili isimlerin semantik tahlilleri yapılmış, Kur’ân’da kaç defa geçtiği ve kime hitaben kullanıldığı ve hangi dönemde nâzil olduğu tespit edilmiş ve de kaynak eserlere müracaat edilerek önceki âyetlerle ilişkisi münâsebâtü’l-Kur’ân ilmi açısından incelenmiştir. Esmâ-i hüsnâ içerisinde azîz, kavî, cebbâr, muktedir, kâdir, melik, kayyûm isimleri, bazen âyet sonlarında, bazen âyet ortasında gelerek Allah’ın otoritesini ifade etmektedir. Ayrıca bu yedi ismin, öncesindeki âyetlerle sıkı bir anlam bağı olup, bu isimler, kimi zaman öncesindeki manaları te’kit etmekte, kimi zamanda bunların gerekçesini bildirmektedir. Otoriteyi ifade eden bu isimler, özellikle şirke karşı tevhidin ikame edildiği bağlamda, mutlak otoritenin Allah’a ait olduğunu ifade sadedinde gelmiştir. Allah Teâlâ, özellikle tarihî kıssaların ve haberlerin sonunda gelen esmâ-i hüsnâ aracılığıyla muhataba kendi otoritesini hissettirmek adına sebeplilik ilkesine bağlı kalmak zorunda olmadığını ifade eden bir anlatım ve üslûp kullanmıştır.
Emevîler Dönemi’nde Siyasi Yaşam ve Edebiyata Etkisi Siyasi Şiir
Authors: Tuna Sedat
Published: January 2023

Emevî Devleti siyasî yaşam şartlarının ve yaşam şekillerinin değişikliğe uğradığı, Arap’ın Arap olanla mücadelesi sonucu kurulan Sahâbe ve Tâbiîn’in daha hayatta olduğu kısa ömürlü hanedan devleti dönemidir. İslâm tarihinin en önemli aşamasını oluşturan bu dönemin en belirgin ve ayırıcı özelliği yaşanan siyasî, fikrî ve askerî olaylarıdır. Câhiliye Dönemi’nde olduğu gibi bu dönemde de kabilelerle ve soyla övünme “asabiyet” zirveye ulaşmıştır. Kabilelerle övünmenin öncü kuvveti kabilesinin lideri konumunda olan kabile şairidir. Bu dönemde şiir hizip mücadelelerine hizmet ederek şairler arasındaki şiir atışmaları “nekâiz” grup taassubunun zirvesine ulaşmıştır. Bu dönem şairleri ya kendi kabilesinin ya desteklediği siyasî grubunun ya da mensubu olduğu mezhebinin resmi sözcüsü, yandaş medyası konumundadır. Ümeyyeoğulları şiirden hoşlanırlar, şiirin önemini ve şairin toplum nezdindeki konumunun farkında idiler. Bundan dolayı şairlere önemli miktarda hediyeler vererek hanedanlıklarını destekleyen taraftarlar toplamışlardır. Çünkü ortaya çıkan her yeni muhalif grubu destekleyen kendi şairleri, sözcüleri vardır. Yönetimi destekleyen şairler adeta yandaş medya muhalif grupları destekleyen şairler de muhalif medya gibiydiler. Siyasî şiir tarih boyunca Arap edebiyatında birçok farklı aşamalardan geçmiş ve her dönemde geçmiş dönemlerden farklı ve ayırıcı özellikleri olmuştur. Şiir, Emevî Dönemi’nde ise daha net bir siyasî yapı kazanıp zirveye yerleşmiştir. Bu çalışmada “Emevî Dönemi siyasî yaşamı, hanedan taraftarı ve Alevî şairlerin şiirlerinin edebiyata siyasî etkisi ile sadece halifelere yaptıkları övgüleri” ele alınacaktır. Emevî hanedanının profesyonel meddahları olan Cerîr, el-Ahtal ve muhalif grupların şairlerinin inşâd ettiği şiirlerden örneklere yer verilmeyecektir.
Improving Life Skills through In School and Out of School Comprehensive Sexuality Education: A Mixed-Methods Evaluation in Four Provinces of Zambia
Authors: Menda Dhally M. , Zulu Joseph , Nawa Mukumbuta , Zimba Rosemary K. , Mulikita Catherine M. , Mwandia Jim , Banda Peter , Sichinga Karen
Published: January 2023

Background: Many countries face several sexual and reproductive health (SRH) challenges, with HIV/ AIDS being one of them, and young people have been greatly affected by HIV [1,2]. It has been suggested that participation in “life skills” education can help reduce HIV related risk behaviours [3]. There have been increased calls for including life skills as a key component of HIV and AIDS education for children and young people [2]. There is a need to ensure that young people develop the life skills relevant to reducing their vulnerability to HIV infection [4,5]. Literature tends to present life skills as a possible solution to several social, gender and general behavioural problems; for example, it is stated that life skills can help trigger political, social and economic participation and help reduce gender inequalities [2]. In addition, life skills are also believed to positively impact deviant social behaviour, crime, and reduction of substance use [6,7].Specifically for HIV, the literature suggests that life skills may positively contribute towards reducing contracting of HIV by, for example, enhancing negotiation and communication skills which may help the young people negotiate for safer sex by making them openly talk about risky sexual behaviours and how they can be prevented [8,9]. Life skills in HIV programming include reproductive and sexual health such as HIV and AIDS, condoms, communication skills, and information on addressing gender-based violence [4,2]. Positive outcomes from these studies included increased communication skills, improved risk perception, reduced stigmatisation of people living with HIV, decreased gender-based violence and improved positive living attitude [2].
A remarkable new snake of the genus Tropidophis (Squamata: Tropidophiidae) from southern Hispaniola
Authors: Landestoy T. Miguel A
Published: January 2023

A new species of Tropidophis is described from the dry forest of the Barahona Peninsula, southwestern Dominican Republic, on the Caribbean island of Hispaniola. There, the new species is parapatric with T. haetianus, the only previously known Tropidophis on Hispaniola, but exhibits striking differences in scalation (much higher number of ventral scales), in other structural morphological traits (head and body proportions), and in dorsal and ventral coloration and pattern (e.g., fewer spot rows, and a patternless head and venter, etc.). The locality of this new species lies within an area where other vertebrate species have been recently discovered, underscoring the growing appreciation of the Barahona Peninsula as a diversity hotspot. Yet, this region also remains poorly studied and it is also highly imperiled due to ongoing anthropogenic change, justifying more conservation efforts.
ANALYSIS OF LAND SUITABILITY FOR EDUCATIONAL AREA IN MAJALENGKA REGENCY
Authors: Harun Din Haq  , Khairunnisa Susilo
Published: January 2023

Educational area has a characteristic educational function that supports the improvement of knowledge, physical, and morals so that students can achieve their highest goals and ideals. The Educational Area of Majalengka Regency is the border point of 3 villages and 1 kelurahan, namely Panyingkiran Village, Jatipamor Village, Jatisawit Village, and Majalengka Village, and the border of 3 sub-districts namely Panyingkiran District, Kasokandel District, and Majalengka District. The Majalengka Regency Education Area, which is planned to use the healthy learning landscape concept, needs to be analyzed for the suitability of the land and whether the supporting activities can support the main educational activities. The purpose of this study is to analyze the suitability of the land around the construction site of the Politeknik Manufaktur Campus so that the area supporting educational activities there is in accordance with the carrying capacity and capacity of the land. The land suitability analysis used is an overlay analysis using the weighting point method. The result is that there are 4 suitability classes, which are not in accordance with the results of score 2 covering an area of 30.4 ha (39.01% of the total area), then quite in accordance with the results of score 3 covering an area of 25.38 ha (32.57% of the total area). , then in accordance with the results of score 4 covering an area of 20.03 ha (25.70% of the total area) and very much in accordance with the results of score 5 covering an area of 2.12 ha (2.72% of the total area).
Gecekonduyu Kente Katmak: Kadın Anlatılarında Hareketlilik
Authors: Bektaş Ata Leyla
Published: January 2023

Bu araştırmada İzmir’in bir gecekondu mahallesinde yaşayan kadınların kent hakkını sorunsallaştırıyorum. İki saha çalışmasına dayanan araştırmanın ilkini 2017 yılında doktora tezim için gerçekleştirdim ve bu mahalede yaşayan kadınların yaşam öykülerini dinledim. Kente yerleşmelerinin üzerinden 30 yılı aşkın süre geçmiş olsa da birinci kuşak kadınların çoğunun kent deneyiminin çok sınırlı olduğunu ve kentin önemli birçok noktasını henüz görmediklerini fark ettim. 2019 yılında yürüttüğüm ikinci saha çalışmasında on kadınla kent deneyimleri üzerine derinlemesine görüşmeler yaptım, gündelik hayatlarındaki hareketliliklerini gözlemledim. Bu aşamada, henüz ziyaret etmedikleri kent mekânlarını belirledim ve ardından bu mekânları kadınlarla ziyaret ettim. Bir süre sonra yaptığım ikinci görüşmede kadınlardan mekân deneyimlerini anlatmalarını istedim. Ekonomik kısıtların, iş hayatına katılımın, çocuklu olmanın, kent tecrübesine sahipliğin, mahallede aşinalığı kaybetmenin, evin sınırlarında yaşamın ve enformel iş yapmanın kentte hareketliliğe etkisini analiz ettiğim bu makalede, her bir temayı bir kadının yaşam öyküsü ve hareketlilik anlatısı üzerinden sürdürüyorum.
Reduction of uncertainty using adaptive modeling under stochastic criteria of information content
Authors: Garanin Dmitry Anatolyevich , Lukashevich Nikita Sergeevich , Efimenko Sergey Vladimirovich , Chernorutsky Igor Georgievich , Barykin Sergey Evgenievich , Kazaryan Ruben , Buniak Vasilii , Parfenov Alexander
Published: January 2023

Entropy is the concepts from the science of information must be used in the situation where undefined behaviors of the parameters are unknown. The behavior of the casual parameters representing the processes under investigation is a problem that the essay explores from many angles. The provided uniformity criterion, which was developed utilizing the maximum entropy of the metric, has high efficiency and straightforward implementation in manual computation, computer software and hardware, and a variety of similarity, recognition, and classification indicators. The tools required to automate the decision-making process in real-world applications, such as the automatic classification of acoustic events or the fault-detection via vibroacoustic methods, are provided by statistical decision theory to the noise and vibration engineer. Other statistical analysis issues can also be resolved using the provided uniformity criterion.
Application of thermosensitive-hydrogel combined with dental pulp stem cells on the injured fallopian tube mucosa in an animal model
Authors: Luo Lihua , Zhu Qunyan , Li Yejian , Hu Fengting , Yu Jiangtao , Liao Xiangyan , Xing Zhenjie , He Yan , Ye Qingsong
Published: January 2023

Objectives: Fallopian tube (FT) injury is an important factor that can lead to tubal infertility. Stem-cell-based therapy shows great potential for the treatment of injured fallopian tube. However, little research has shown that mesenchymal stem cells (MSCs) can be used to treat fallopian tube damage by in situ injection. In this study, we in situ transplanted PF127 hydrogel encapsulating dental pulp stem cells (DPSCs) into the injured sites to promote the repair and regeneration of fallopian tube injury.

Materials and methods: The properties of dental pulp stem cells were evaluated by flow cytometry, immunofluorescence analysis, and multi-differentiation detection. The immunomodulatory and angiogenic characteristics of dental pulp stem cells were analyzed on the basis of the detection of inflammatory factor expression and the formation of capillary-like structures, respectively. The biocompatibility of PF127 hydrogel was evaluated by using Live/Dead and CCK-8 assays. The effects of PF127 hydrogel containing dental pulp stem cells on the repair and regeneration of fallopian tube injury were evaluated by histological analysis [e.g., hematoxylin and eosin (H&E) and Masson’s trichrome staining, TUNEL staining, immunofluorescence staining, and immunohistochemistry], Enzyme-linked immunosorbent assay (ELISA), and RT-PCR detections.

Results: Dental pulp stem cells had MSC-like characteristics and great immunomodulatory and angiogenic properties. PF127 hydrogel had a thermosensitive feature and great cytocompatibility with dental pulp stem cells. In addition, our results indicated that PF127 hydrogel containing dental pulp stem cells could promote the repair and regeneration of fallopian tube damage by inhibiting cell apoptosis, stimulating the secretion of angiogenic factors, promoting cell proliferation, modulating the secretion of inflammatory factors, and restoring the secretion of epithelial cells.

Conclusion: In this study, our results reported that in situ injection of PF127 hydrogel encapsulating dental pulp stem cells into the injured sites could provide an attractive strategy for the future treatment of fallopian tube injury in clinical settings.
Advances in 3D bioprinting technology for functional corneal reconstruction and regeneration
Authors: Jia Shuo , Bu Yashan , Lau Dzi-Shing Aaron , Lin Zhizhen , Sun Tianhao , Lu Weijia William , Lu Sheng , Ruan Changshun , Chan Cheuk-Hung Jonathan
Published: January 2023

Corneal transplantation constitutes one of the major treatments in severe cases of corneal diseases. The lack of cornea donors as well as other limitations of corneal transplantation necessitate the development of artificial corneal substitutes. Biosynthetic cornea model using 3D printing technique is promising to generate artificial corneal structure that can resemble the structure of the native human cornea and is applicable for regenerative medicine. Research on bioprinting artificial cornea has raised interest into the wide range of materials and cells that can be utilized as bioinks for optimal clarity, biocompatibility, and tectonic strength. With continued advances in biomaterials science and printing technology, it is believed that bioprinted cornea will eventually achieve a level of clinical functionality and practicality as to replace donated corneal tissues, with their associated limitations such as limited or unsteady supply, and possible infectious disease transmission. Here, we review the literature on bioprinting strategies, 3D corneal modelling, material options, and cellularization strategies in relation to keratoprosthesis design. The progress, limitations and expectations of recent cases of 3D bioprinting of artifial cornea are discussed. An outlook on the rise of 3D bioprinting in corneal reconstruction and regeneration is provided.
Synthesis, optimization, and cell response investigations of natural-based, thermoresponsive, injectable hydrogel: An attitude for 3D hepatocyte encapsulation and cell therapy
Authors: Gholami Mahnaz , Tajabadi Maryam , Khavandi Alireza , Azarpira Negar
Published: January 2023

For the purpose of developing a 3D vehicle for the delivery of hepatocytes in cell therapy, the improved system of crosslinker and new gelling agent combinations consisting of glycerophosphate and sodium hydrogen carbonate have been employed to produce injectable, thermoresponsive hydrogels based on chitosan and silk fibroin. Adjusting the polymer-to-gelling agent ratio and utilizing a chemical crosslinker developed hydrogel scaffolds with optimal gelling time and pH. Applying sodium hydrogen carbonate neutralizes chitosan while keeping its thermoresponsive characteristics and decreases glycerophosphate from 60% to 30%. Genipin boosts the mechanical properties of hydrogel without affecting the gel time. Due to their stable microstructure and lower amine availability, genipin-containing materials have a low swelling ratio, around six compared to eight for those without genipin. Hydrogels that are crosslinked degrade about half as fast as those that are not. The slowerr degradation of Silk fibroin compared to chitosan makes it an efficient degradation inhibitor in silk-containing formulations. All of the optimized samples showed less than 5% hemolytic activity, indicating that they lacked hemolytic characteristics. The acceptable cell viability in crosslinked hydrogels ranges from 72% to 91% due to the decreasing total salt concentration, which protects cells from hyperosmolality. The pH of hydrogels and their interstitial pores kept most encapsulated cells alive and functioning for 24 h. Urea levels are higher in the encapsulation condition compared to HepG2 cultivated alone, and this may be due to cell-matrix interactions that boost liver-specific activity. Urea synthesis in genipin crosslinked hydrogels increased dramatically from day 1 (about 4 mg dl−1) to day 3 (approximately 6 mg dl−1), suggesting the enormous potential of these hydrogels for cell milieu preparation. All mentioned findings represent that the optimized system may be a promising candidate for liver regeneration.
The journey of demand responsive transportation: Towards sustainable services
Authors: Deka Utpal , Varshini Vetha , Dilip Deepthi Mary
Published: January 2023

The concept of Demand Responsive Transport (DRT) describes a technology-enabled shared mobility service that has a flexible operating schedule and/or provides virtual stops and/or flexible routes. While these on-demand services are not new, the developments in communication and tracking technology (vehicle positioning systems) have revived these services in the past decade. The benefits of adopting demand responsive transport services for intra-community and FLM travel needs are widely accepted, but there is still a cautious approach towards their implementation due to the failure of many promising demand responsive transport schemes in the past. This article 1) creates an overview of the various on-demand services introduced across the world, to understand the factors that may have contributed to the failure of these services in the past 2) identifies the progress made towards sustainable demand responsive transport ventures through analysis of global case studies 3) provides an overview of the flexibility of vehicle and deployment technologies in the demand responsive transport sphere. A bibliometric analysis, where the top keywords were further categorised using VOSviewer’s default clustering algorithm, highlighted the importance of sustainability in demand responsive transport ventures. By the progress made towards sustainable demand responsive transport ventures, it can be concluded that environmentally sustainable demand responsive transport ventures can be achieved through the adoption of electric and autonomous vehicles for demand responsive transport services, by reducing mileage of the vehicle and/or adjusting the length of route. The study concludes by reviewing existing research gaps regarding performance expectation, and recommending policy and practice implications, based on the case study of the Bus-on-Demand in Dubai, UAE.
ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts
Authors: Pecori Riccardo , Chillón Isabel , Lo Giudice Claudio , Arnold Annette , Wüst Sandra , Binder Marco , Marcia Marco , Picardi Ernesto , Papavasiliou Fotini Nina
Published: January 2023

Despite hundreds of RNA modifications described to date, only RNA editing results in a change in the nucleotide sequence of RNA molecules compared to the genome. In mammals, two kinds of RNA editing have been described so far, adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. Recent improvements in RNA sequencing technologies have led to the discovery of a continuously growing number of editing sites. These methods are powerful but not error-free, making routine validation of newly-described editing sites necessary. During one of these validations on DDX58 mRNA, along with A-to-I RNA editing sites, we encountered putative U-to-C editing. These U-to-C edits were present in several cell lines and appeared regulated in response to specific environmental stimuli. The same findings were also observed for the human long intergenic non-coding RNA p21 (hLincRNA-p21). A more in-depth analysis revealed that putative U-to-C edits result from A-to-I editing on overlapping antisense RNAs that are transcribed from the same loci. Such editing events, occurring on overlapping genes transcribed in opposite directions, have recently been demonstrated to be immunogenic and have been linked with autoimmune and immune-related diseases. Our findings, also confirmed by deep transcriptome data, demonstrate that such loci can be recognized simply through the presence of A-to-I and U-to-C mismatches within the same locus, reflective A-to-I editing both in the sense-oriented transcript and in the cis-natural antisense transcript (cis-NAT), implying that such clusters could be a mark of functionally relevant ADAR1 editing events.
Insights from targeting transferrin receptors to develop vaccines for pathogens of humans and food production animals
Authors: Ewasechko Nikolas F. , Chaudhuri Somshukla , Schryvers Anthony B.
Published: January 2023

While developing vaccines targeting surface transferrin receptor proteins in Gram-negative pathogens of humans and food production animals, the common features derived from their evolutionary origins has provided us with insights on how improvements could be implemented in the various stages of research and vaccine development. These pathogens are adapted to live exclusively on the mucosal surfaces of the upper respiratory or genitourinary tract of their host and rely on their receptors to acquire iron from transferrin for survival, indicating that there likely are common mechanisms for delivering transferrin to the mucosal surfaces that should be explored. The modern-day receptors are derived from those present in bacteria that lived over 320 million years ago. The pathogens represent the most host adapted members of their bacterial lineages and may possess factors that enable them to have strong association with the mucosal epithelial cells, thus likely reside in a different niche than the commensal members of the bacterial lineage. The bacterial pathogens normally lead a commensal lifestyle which presents challenges for development of relevant infection models as most infection models either exclude the early stages of colonization or subsequent disease development, and the immune mechanisms at the mucosal surface that would prevent disease are not evident. Development of infection models emulating natural horizontal disease transmission are also lacking. Our aim is to share our insights from the study of pathogens of humans and food production animals with individuals involved in vaccine development, maintaining health or regulation of products in the human and animal health sectors.
Transcription factors in the pathogenesis of pulmonary arterial hypertension—Current knowledge and therapeutic potential
Authors: Körbelin Jakob , Klein Julius , Matuszcak Christiane , Runge Johannes , Harbaum Lars , Klose Hans , Hennigs Jan K.
Published: January 2023

Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pulmonary vascular resistance and pulmonary artery pressure. Mortality remains high in severe cases despite significant advances in management and pharmacotherapy. Since currently approved PAH therapies are unable to significantly reverse pathological vessel remodeling, novel disease-modifying, targeted therapeutics are needed. Pathogenetically, PAH is characterized by vessel wall cell dysfunction with consecutive remodeling of the pulmonary vasculature and the right heart. Transcription factors (TFs) regulate the process of transcribing DNA into RNA and, in the pulmonary circulation, control the response of pulmonary vascular cells to macro- and microenvironmental stimuli. Often, TFs form complex protein interaction networks with other TFs or co-factors to allow for fine-tuning of gene expression. Therefore, identification of the underlying molecular mechanisms of TF (dys-)function is essential to develop tailored modulation strategies in PAH. This current review provides a compendium-style overview of TFs and TF complexes associated with PAH pathogenesis and highlights their potential as targets for vasculoregenerative or reverse remodeling therapies.
Role of follistatin-like 1 levels and functions in calcific aortic stenosis
Authors: Zhang Qianru , Ye Jiawen , Yang Gan , Yang Ling , Chen Zhongli , Yang Ke , Sun Jia Teng , Liu Yan
Published: January 2023

Background

Calcific aortic valve disease (CAVD) is a progressive disease resulting in severe calcific aortic stenosis (AS), and there is increasing interest in the discovery of novel biomarkers to identify patients with potential future calcific AS at an early stage. This study aimed to determine whether follistatin-like 1 (FSTL1) is associated with calcific AS events and its exact role in aortic valve calcification.

Methods

A prospective observational cohort study involving 656 patients was performed to investigate the relationship between serum FSTL1 and calcific AS incidence during a follow-up of 5 years. Furthermore, we detected FSTL1 levels in valvular interstitial cells (VICs) from calcified valves and explored the effects of FSTL1 on VIC osteogenic differentiation in vitro as well as the signaling pathways involved.

Results

During a median follow-up of 5 years, lower FSTL1 levels were associated with a significantly higher risk of calcific AS events (log rank test, P = 0.007). In addition, Cox multivariable regression analyses verified the predictive value of FSTL1 after adjusting for both demographic features and laboratory confounders. Consistent with our results for serum, a lower concentration of FSTL1 was observed in calcified human valves (n = 11) and mainly colocalized with VICs. Recombinant human FSTL1 (rhFSTL1) stimulation inhibited calcium deposition, alkaline phosphatase (ALP) activity, and osteogenic gene expression partly through the downregulation of the ERK1/2 pathway.

Conclusion

Taken together, this study provides a strong rationale to consider FSTL1 as a potential therapeutic target for calcific AS.
A bibliometric analysis on the progress of myocardial bridge from 1980 to 2022
Authors: Chen Liang , Yu Wen-Yuan , Liu Rui , Gao Ming-Xin , Wang Bo-Lin , Ding Xiao-Hang , Yu Yang
Published: January 2023

Introduction

Although the vast majority of patients with a myocardial bridge (MB) are asymptomatic, the anomaly was found to be associated with stable or unstable angina, vasospastic angina, acute coronary syndrome, and even malignant arrhythmias and sudden cardiac death in some cases.

Methods

By retrieving the relevant literature on MB from 1 January 1980 to 31 July 2022 from the Web of Science Core Collection (WoSCC) database, we used the bibliometric tools, including CiteSpace, VOS viewer, and alluvial generator, to visualize the scientific achievements on MB.

Results

A total of 630 articles were included. The number of published articles was in a fluctuating growth trend. These publications came from 37 contries, led by the USA and China. The leading country on MB was the United States, the leading position among institutions was Stanford University, and the most productive researcher on MB was Jennifer A. Tremmel. After analysis, the most common keywords were myocardial bridge, mortality, coronary angiography, descending coronary artery, and sudden death.

Conclusion

Our findings can aid researchers in understanding the current state of MB research and in choosing fresh lines of inquiry for forthcoming investigations. Prevalence and prognosis, mechanism atherosclerosis, hemodynamic significance, and molecular autops will likely become the focus of future research. In addition, more studies and cooperations are still needed worldwide.
Microvascular significance of TGF-β axis activation in COVID-19
Authors: Arguinchona Lauren M. , Zagona-Prizio Caterina , Joyce Megan E. , Chan Edward D. , Maloney James P.
Published: January 2023

As 2023 approaches, the COVID-19 pandemic has killed millions. While vaccines have been a crucial intervention, only a few effective medications exist for prevention and treatment of COVID-19 in breakthrough cases or in unvaccinated or immunocompromised patients. SARS-CoV-2 displays early and unusual features of micro-thrombosis and immune dysregulation that target endothelial beds of the lungs, skin, and other organs. Notably, anticoagulation improves outcomes in some COVID-19 patients. The protein transforming growth factor-beta (TGF-β1) has constitutive roles in maintaining a healthy microvasculature through its roles in regulating inflammation, clotting, and wound healing. However, after infection (including viral infection) TGF-β1 activation may augment coagulation, cause immune dysregulation, and direct a path toward tissue fibrosis. Dysregulation of TGF-β signaling in immune cells and its localization in areas of microvascular injury are now well-described in COVID-19, and such events may contribute to the acute respiratory distress syndrome and skin micro-thrombosis outcomes frequently seen in severe COVID-19. The high concentration of TGF-β in platelets and in other cells within microvascular thrombi, its ability to activate the clotting cascade and dysregulate immune pathways, and its pro-fibrotic properties all contribute to a unique milieu in the COVID-19 microvasculature. This unique environment allows for propagation of microvascular clotting and immune dysregulation. In this review we summarize the physiological functions of TGF-β and detail the evidence for its effects on the microvasculature in COVID-19. In addition, we explore the potential role of existing TGF-β inhibitors for the prevention and treatment of COVID-19 associated microvascular thrombosis and immune dysregulation.