bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Behavioral Characteristics After Hearing in Children with Cochlear Implants
Authors: Sari Elif , Aliyeva Aynur , Bozkurt Ergül Başaran , Aydın Çiğdem Yılmaz , Sari Ferhat , Olgun Levent
Published: September 2023

Objective: Cochlear implantation (CI) is an electronic device that converts mechanical sound energy into electrical signals and transmits it directly to the cochlea, allowing sound perception. These implants were applied to patients with severe sensorineural hearing loss who did not or had little benefit from the conventional hearing devices. This study aimed to investigate behavioral problems, find related factors, and determine the relationship between behavioral problems and parents' attitudes in children with CI.
Materials and Methods: The investigation involved the participation of fifty individuals, comprising 26 males and 24 females, between 4 and 18 years, with a mean age average of 4±1.56 without any neurological and developmental problems. Inclusion criteria required a minimum of one year post-CI follow-up and a corresponding minimum duration of one year utilizing CI. Achenbach's Child Behavior Checklist (CBCL) assessed behavioral aspects. Categories of Auditory Performance II (CAP) and The Speech Intelligibility Rating Scale (SIR) scales were employed to evaluate auditory performance and speech intelligibility. Parental attitudes were gauged using the Parent Attitude Research Instrument (PARI). The selection of fifty patients was accomplished through a simple random sampling technique, with no considerations for gender or social status differences during case selection.
Results: The patients who applied the CI bilaterally were more successful than the one-sided. The success rate of patients who had comorbidities was statistically significant. Aggressive behavior was less in patients operated on before age 4. There are no differences between the relations of friend circle, art, and sports-interested patients. For CAP II and SIR, there is a moderate statistical significance between the duration of use and CAP. CAP scores were analyzed high in patients who used the device for over six years. There is a moderate statistical significance between CAP and SIR correlation. Our research found a statistically significant decrease in all behavioral scales when comparing preoperative and postoperative scores. Although there was only a non-significant decrease in the delinquent behaviors score, a decrease was still observed. There were significant changes in males but no significant difference based on gender in our study.
Conclusion: The findings imply that implementing cochlear implants in younger children might yield even greater advantages. Our research adds to the expanding collection of evidence endorsing CI as a viable therapeutic choice for youngsters with hearing impairments, underscoring the necessity for continued investigations within this domain.
Investigation of the Relationship between Adenoma Volume and Perioperative Hormone Levels in Patients with Acromegaly
Authors: Erkutlu İbrahim , Demir Atilla , Üçler Necati , Uğur Berna Kaya , Geyik Murat , Nehir Ali
Published: September 2023

Objective: Current pituitary adenomas classifications and surgical treatment results are made only with two-dimensional radiological sections and hormonal measurements. This study investigated the relationship between hormone levels and volumetric tumor burden by measuring tumor volumes before and after surgery in patients with acromegaly.
Methods: In a retrospective clinical study, clinical and radiologically measured volumetric, hormonal and surgical results of 52 patients who were operated on with the diagnosis of acromegaly due to pituitary adenoma were examined. Radiological measurements were obtained using the ImageJ software package version 1.47 and the measure-stack plug-in. In statistical analysis, the relationship between tumor volumes, growth horomone (GH) and insulin-like growth factor (IGF-I) levels was analyzed during and after surgery.
Results: Of the 52 cases, 22 (42.3%) were male, 30 (57.7%) were female, and the mean age of the patients was 43.40±11.40 years. 45 cases (86.53%) were macroadenoma, 7 cases (13.47%) were microadenoma. All patients were operated by the transnasal-transseptal-transsphenoidal route. When the early preoperative and postoperative hormone results of the patients were compared, significant decreases were observed in GH (82.1%), volume (67%), and IGF-1 (50%) levels in the postoperative period. While there was a significant positive correlation between preoperative GH levels and tumor volumes (r: 0.516, p<0.05), there was also a significant positive correlation between postoperative GH levels and tumor volumes (r: 0.755, p<0.05). No correlation was observed between IGF-I levels and volume in the preoperative and postoperative period (r:-0.051, p>0.05) (r:0.259, p>0.05). A significant positive correlation was found between postoperative GH levels and IGF-1 levels (r: 0.303, p<0.05).
Conclusion: Both GH and IGF-I levels increase significantly as tumor volume increases in patients with pituitary adenoma before and after surgical treatment. Volumetric measurements may be necessary for classifying patients with acromegaly before and after surgery and in the more objective and quantitative determination of postoperative residual and/or recurrence. For this reason, we believe that it is more accurate to evaluate tumor tissues occupying a 3-dimensional volume with volumetric measurements.
Scabies Surrepticus Presenting As Chronic Urticaria – A Case Report And Literally Review Of Diagnosis Method And Treatment
Authors:   Department Of Infecrion Diseases, Parasitology And Dermatovenerology, Faculty Of Medicine, Medical University, Varna, Velevska Yoanna , Georgieva Filka ,   Department Of Infecrion Diseases, Parasitology And Dermatovenerology, Faculty Of Medicine, Medical University, Varna, Stoyanova Zhenya ,   Department Of Infecrion Diseases, Parasitology And Dermatovenerology, Faculty Of Medicine, Medical University, Varna
Published: September 2023

Scabies surrepticius represents the non-classic atypical presentation of scabies and diagnosing scabies in these individuals could be difficult. We present a clinical case of a 71-year-old woman with intense body pruritus for about 2 years, unresponsive to oral and topical antibiotics, corticosteroid creams, topical calcineurin inhibitors, as well as antiallergic agents, due to a suspected allergic reaction.
A atualidade da leitura freudiana sobre fenômenos grupais
Authors: Lima Prof. Dr. Marco Aurélio de
Published: September 2023

Este artigo se propõe a fazer uma discussão da perspectiva psicanalítica a respeito dos chamados fenômenos de massa. O objetivo é produzir algumas reflexões sobre a adesão incondicional a um líder e a construção de uma realidade particular pelos indivíduos do grupo. Partimos de situações do cenário brasileiro descritas por alguns meios de comunicação para, então, debruçarmo-nos na obra “Psicologia das Massas e Análise do Eu”, de Sigmund Freud. Uma das conclusões que o psicanalista apresenta é a de que o indivíduo na massa é capaz de substituir suas instâncias internas de controle, como a consciência moral, pela figura do líder, que passa a exercer grande influência sobre a “alma coletiva” da massa.
Analysis and simulations of the HANDY model with social mobility, renewables and nonrenewables
Authors: Shillor Meir , Kadhim Thanaa Ali
Published: September 2023

We expand the HANDY (Human And Nature DYnamics) model for the socioeconomic dynamics of a large stratified society. The basic model was introduced in Motesharrei (Dissertation 2014) and Motesharrei et al. (2016). It is a nonlinear system of ODEs for a `simple society' of Elites, Workers, Wealth, and Natural Resources. Following Ali Kadhim (Dissertation 2021), we add social mobility between the classes and split natural resources into renewables and nonrenewables. We establish the existence, boundedness and positivity of the solutions, and investigates the stability of the steady states. The model admits stable steady states, and there is numerical evidence of stable periodic solutions and limit cycles. Simulations depict the different qualitative types of model behavior: convergence to steady states, periodic oscillations, collapse.

For more information see https://ejde.math.txstate.edu/Volumes/2023/59/abstr.html
Species boundaries in Lippia asperrima and Lippia turnerifolia complex (Verbenaceae)
Authors: Deble Leonardo Paz , Moreira Bárbara , Keller Hector , Souza Velci
Published: September 2023

Species boundaries in Lippia asperrima and Lippia turnerifolia complex (Verbenaceae)

The specific boundaries of Lippia asperrima and L. turnerifolia are discussed. Lippia contermina is accepted as segregated of L. asperrima, while L. modesta and L. Morongii are rehabilitated of the synonym of L. turnerifolia. Lantana ovata and Lippia contermina var. hirsuta are recognized as new synonymies of Lippia contermina, whereas Lippia trachyphylla is treated as cospecific of L. modesta, and L. asperima f. angustifolia is reduced under L. Morongii. All treated species are described and illustrated, and information on taxonomic relationships and morphological limits are discussed. A Dichotomous key for distinguishing the species of Lippia sect. Dioicolippia is proposed. Lippia sect Dioicolippia comprises 21 species distributed mainly in southern and centralwestern Brazil, northeast and northern Argentina, Paraguay and Uruguay.
A STUDY TO ESTABLISH THE RELATIONSHIP BETWEEN DEPRESSION AND OSTEOARTHRITIS ACCORDING TO THE SEVERITY OF PAIN AND LOSS OF FUNCTION
Authors: Javed Fatima , Ibrahim Fatima , Naeem Shanzae , Ahmad Omar , Sehar Sadaf , Muzamil Talha
Published: September 2023

Objective:  To establish a relationship between depression and osteoarthritis according to the severity of pain and loss of function.  

Study Design: Cross-sectional study.

Place and Duration of study: Orthopedic and Rheumatology department of Combined Military Hospital, Lahore from October 2022 to March 2023

Patients and Methods: All the patients reporting to the outpatient department of either gender aged more than 45 years with a diagnosis of OA based on X-ray findings and a consultant review were included in our study. Severity of OA was studied using the WOMAC (Western Ontario and McMaster Universities) Osteoarthritis Index. Depression was measured using the Personal Health Questionnaire (PHQ-9) scale in these patients simultaneously. (12) It was translated in Urdu for the ease of our participants.

Results:  Out of the 196 participants of our study, 71 (36.2%) were males while 125 (63.8%) were females. Mean age of the participants of our study was 55.49 Years + 8.98. Mean WOMAC index score was 61.02 + 19.11. 3 (1.5%) patients of OA had mild disease in our study and no depression was found in them. In the moderate disease group, 34 (17.3%) had no symptoms of depression, 62 (31.6%) had minimal depression, none had mild, moderate or severe depression while only 1 (0.5%) had moderately severe depression. Out of 96 (48.9%) of the OA patients with severe disease as per the WOMAC index, 3 (1.5%) had minimal depression, 47 (23.9%) had mild depression, 15 (7.6%) had moderate depression, 27 (13.8%) had moderately severe depression and 4 (2.0%) had severe depression.

Conclusion:  OA is a debilitating disease. Quality of life of patients is severely affected as the duration increases due to pain, stiffness and loss of function of joints. Long term disease leads to depression of variable degrees. . Thus early diagnosis and timely intervention in such patients with an individualized management plan can improve the outcome and quality of life of patients.

 

Keywords:  Osteoarthritis, Depression, Morbidity
Comparing the Frequency of Left Main Stem Disease Among Patients with ST Elevation in AVR Lead
Authors: Mariam Tahir Siddiqi  , Ahmad Kamran Dawood , Bhatti Muhammad Ijaz , Hameed Shahid , Rajia Liaqat  , Usama Khawaja Muhammad
Published: September 2023

Background: Coronary artery disease (CAD) is one of the leading causes of mortality worldwide with similar prevalence in Pakistan. The main objective of the study is to compare the frequency of left main stem disease among patients with STelevation in aVR. Methods:This cross-sectionalstudywas conducted inDepartment of cardiology,Punjab institute of cardiology,Lahore. Sample size of 151 cases is calculated with 95% confidence level,7%margin of error and taking expected percentage of LMS is 74.2%. The data was collected through non probability consecutive sampling technique. Results: Mean age of the study population was 55.54±10.1 years. Majority of the cases were male 117(77.5%)and 34(22.5%) were female which were less in quantity. Mean body mass index was 28.61±2.58. Conclusion: Majority of the cases developed left mainstem disease who have been diagnosed with STelevation in aVR. A significant difference of the diabetic versus non diabetic was observed who have been noted for LMS disease.
MICROALBUMINURIA IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS AND ITS CORRELATION WITH LEFT VENTRICULAR HYPERTROPHY”
Authors: Khalid Mehmood Khan  , Muzammal Aslam kataria  , Mohammad Saddam Rahman  , Kanwal Rehana , Farooq Hassan , Arif Rana Muhammad
Published: September 2023

Background: One of the most important factors in the development of cardiovascular diseases worldwide is Hypertension. A reliable indicator and a diagnostic modality in early stage of renal diseases and predictor of atrial hypertension (AH) progression is microalbminurea (MAU) which is also an independent risk factor of cardiovascular mortality and death.

Objective: To determine the prevalence of microalbuminuria and left vertricular hypertrophy and assess correlation between micro albuminuria and LVH among newly diagnosed hypertensive patients.

Methods: A cross sectional study conducted in Medical Unit IV, Jinnah Hospial Lahore from January to June, 2022. About 146 adults newly diagnosed hypertensive patients were included for study. Blood pressure was measured using sphygmomanometer with standard cuff in sitting position, with two measurements were made at least 5 min apart. Microalbuminuria was defined as albumin excretion 30 to 300 mg/dl in a spot urine sample report. Left ventricular hypertrophy (LVH) is defined as presence of concentric hypertrophy or diastolic dysfunction determined on Trans Thoracic ECHO by a cardiologist. Data was entered in SPSS Ver: 25.0 for data analysis and graphical presentation. For quantitative variables like age, ACR; mean and standard deviation was calculated. Prevalence and correlation of MAU and LVH in newly diagnosed hypertensive patients was using Spearmen’s Rank Correlation Analysis. Chi-square test was performed to compare MAU and LVH. P-value of < 0.05 was considered statistically significant. 

Results: 146 subjects those fulfilling the inclusion criteria were admitted. Mean age was 48.281 + 24.865. 72.6% were male in our study. 30.8% of patients had LVH and microbuminurea was present in 47.5% of subject. About 28.6% of patient with LVH had MAU. (p=.030). There was a positive correlation between LVH and MAU. (r=0.135, P =.002).

Conclusions: Our study concludes a high prevalence of micro albuminuria and LVH in newly diagnosed hypertensive. There is positive correlation between micro albuminuria and LVH and can be predictor of cardiovascular morbidity and mortality.
GOOD GOVERNANCE AND THE USE OF SOCIAL NETWORKS FOR AGRIBUSINESS IN NIGERIA
Authors: Oluwalowi Ismail Akinbami , Daoud Balogun Adekunle , Hassan Isyaku
Published: September 2023

The world population increases rapidly, and hence food supply, proportional to the need of the teeming population, remains a critical challenge confronting stakeholders. Thus, there is a need to develop strategies to boost agriculture, and this course must be planned, arranged, tested, evaluated, and implemented. In this context, good governance and the use of social networks are proven to make a tremendous contribution in boosting agricultural outputs. Nigeria was an agro-based nation until oil products were discovered in the middle of the 1950s. This discovery led to the country’s over-dependence on oil products, which negatively altered its level of food production. However, the current administration is determined to “diversify the country’s oil-denominated economy by investing more in agriculture and encouraging farming. Thus, this paper discusses how good governance and the use of social networks can help promote agribusiness in the Nigerian context. Discussion of this kind is crucial as good governance determines the success or failure of a given nation, and society depends, to a certain extent, on the media for information about various aspects of life, including agriculture. The outcomes of this study are expected to advance our knowledge and suggest further evidence-based research on good governance and the use of social media for agribusiness promotion.
Ginecologia e Obstetrícia - Edição VI
Authors: Barroso Langoni de Freitas Guilherme
Published: September 2023

Desde a puberdade, menarca, desenvolvimento das mamas, gravidez até a menopausa, doenças significativas afetam as mulheres. uma equipe multidisciplinar poderá assistir da melhor forma esta mulher e ser apoio fundamental no trabalho do médico ginecologista. A partir da maturidade, quando os órgãos reprodutivos amadurecem, as mulheres são aconselhadas a fazer um exame de saúde anual ou pelo menos a cada 3 anos com um ginecologista, porém muitas delas não terão esse acesso com facilidade pelos serviços públicos de saúde ou ainda se depararão com profissionais sem a formação adequada. A consciência das funções corporais básicas e a manutenção de um bom bemestar físico e mental são aspectos vitais da gestão da saúde da mulher e no bom atendimento ginecológico e obstétrico. A detecção precoce de doenças e outros problemas de saúde pode ser importante para ajudar qualquer paciente a ter uma vida mais saudável, feliz e, em alguns casos, mais longa. Na verdade, a detecção precoce e bom manejo da paciente pode aumentar significativamente as chances de sobrevivência de certas doenças, incluindo muitas formas de câncer. É por isso que os especialistas recomendam a adesão a um cronograma regular de exames médicos e exames apropriados com base em seus dados demográficos e fatores de risco. O livro Ginecologia e Obstetrícia aborda capítulos sobre sexualidade, atendimento clínico, cuidados do aparelho genital feminino e intervenções cirúrgicas e medicamentosas para as principais complicações. O leitor encontrará capítulos pré-definidos, construídos por autores convidados e atualizados sobre os principais temas. A Editora Pasteur fica feliz em apresentar esse material de alta qualidade e importância.
Discovering and learning everything there is to know about R packages using r-universe
Authors: Ooms Jeroen
Published: September 2023

Finding the right tool for the job The hardest part about effectively using R is finding the best packages for the problem you are trying to solve. I think this is even more important than being fluent in the language itself, which you will pick up along the way as you start using R more frequently. However, building your code on reliable foundations is essential for good results, and difficult to fix later on in a project.
Open Call for rOpenSci Champions Program Applications!
Authors: Saibene Yanina Bellini
Published: September 2023

We are pleased to open the call for the second cohort of

Champions and Mentors

for the rOpenSci Champions Program 🎉 ! This program will continue to support our goal of identifying, recognizing, and rewarding passionate community members who help the community grow and improve.
postdoc 1.0: minimal and uncluttered HTML package manuals
Authors: Ooms Jeroen
Published: September 2023

Two new packages! We released two new packages that we are using in r-universe to render package documentation: postdoc and prismjs. The goal of postdoc is very simple: generate beautiful single-page package manuals in HTML format. Postdoc uses our prismjs and katex packages for server-side highlighting and math.
Maintain or Co-Maintain an rOpenSci Package!
Authors: Salmon Maëlle , LaZerte Steffi
Published: September 2023

The rOpenSci suite of packages is mainly composed of packages contributed by the community through peer-review, but also includes some packages maintained by staff.Over time, the commitments and availability of the original developers of a package can change. This leads to some maintainers stepping down from their maintainer role, or other maintainers looking to lower their workload through more teamwork and therefore looking for co-maintainers.
curl 5.0.0: massive concurrent downloads and HTTP/2
Authors: Ooms Jeroen
Published: September 2023

curl 5.0.0 is on CRAN A new major version of the curl package has been released to CRAN. This release both brings internal improvements as well as new user-facing functionality, in particular with respect to concurrent downloads. From the NEWS file:curl 5.0.0 - New function multi_download() which supports concurrent downloads and resuming download for large files, while giving detailed progress information.
New preferred repo name for r-universe registries
Authors: Ooms Jeroen
Published: September 2023

Running your own package registry Tiny update for r-universe users whos run their own package registry: we have changed the preferred git repo name where you host your packages.json registry file. Previously the git repository was simply called universe, i.e. the registry for tiledb-inc.r-universe.dev was in the GitHub repository tiledb-inc/universe.
Why You Should (or Shouldn't) Build an API Client
Authors: Salmon Maëlle , Grenié Matthias , Gruson Hugo
Published: September 2023

These days web Application Programming Interfaces (APIs) are everywhere (scientific data sources, your system for Customer relationship management, cat facts API…). Do you need to write some R code wrapping a web resource such as an API? Packaging it up might be useful to you or your team for the same reason as any code.
rOpenSci 2022 Code of Conduct Transparency Report
Authors: Saibene Yanina Bellini , Padgham Mark , Woo Kara
Published: September 2023

The rOpenSci community is supported by our Code of Conduct with a clear description of unacceptable behaviors,instructions on how to make a report, and information on how reports are handled. We, the Code of Conduct Committee,are responsible for receiving, investigating, deciding, enforcing and reporting on all reports of potentialviolations of our Code.
Meeting the Stars of the R-universe: ThinkR's Approach to Contributing to a Growing and Friendly R Community
Authors: Saibene Yanina Bellini , Rochette Sébastien , Bellini Alejandra , Casalla Lucio , LaZerte Steffi
Published: September 2023

This is the second post of our interview series “Meeting the stars of the R-universe”. We aim to introduce the working groups and people behind the development of software and packages many of us use and which are available through the R-universe. We want to highlight and explore different teams and projects around the world, the work they do, their processes and users.
All About Coworking Sessions with rOpenSci
Authors: LaZerte Steffi
Published: September 2023

We first introduced our Coworking andOffice Hour sessions in August 2021 after a successful pilot of several’label-athon’s in the April and May prior. We’ve had a successful couple of years since then and the coworking sessionshave evolved into themed events with different community hosts and me asa facilitator. It’s been a lovely change and we thought it was time to share these updates with the rOpenSci community! 🎉What are these sessions?
rOpenSci News Digest, September 2022
Authors:   The rOpenSci Team
Published: September 2023

Dear rOpenSci friends, it’s time for our monthly news roundup! You can read this post on our blog.Now let’s dive into the activity at and around rOpenSci!rOpenSci HQ We are thrilled to launch our Champions program!
rOpenSci News Digest, August 2022
Authors:   The rOpenSci Team
Published: September 2023

Dear rOpenSci friends, it’s time for our monthly news roundup! You can read this post on our blog.Now let’s dive into the activity at and around rOpenSci!rOpenSci HQ Coworking sessions resume! Join us for social coworking & office hours monthly on first Tuesdays!Hosted by Steffi LaZerte and various community hosts.Everyone welcome.No RSVP needed.Consult our Events page to find your local time and how to join.
What Does It Mean to Maintain a Package?
Authors: Salmon Maëlle
Published: September 2023

Part of what we aim to do at rOpenSci is nurture a community of package maintainers who help each other.In addition to support during package maintenance, we also want to support maintainers who wish to move on. Situations can change, and there may come a time when a maintainer is looking to pass maintenance on to another.
How to Participate with rOpenSci
Authors: Saibene Yanina Bellini
Published: September 2023

This blog post is intended to help you get started in rOpenSci community by highlighting some key links and activities. If you have questions, please get in touch with our Community Manager, Yanina Bellini Saibene by email or schedule a meeting. We are here for you as you begin your journey with our community. Welcome!Where do I get started? Glad you asked!
Communication & Collaboration with Contributors in an Open-Source Organization
Authors: Salmon Maëlle , Kamvar Zhian N.
Published: September 2023

Zhiam Kamvar is Lesson Infrastructure Technology Developer at The Carpentries (Software Carpentry, Data Carpentry & Library Carpentry), an open global community teaching the skills &
The influence of a highly-valued market on M&A activity
Authors: Fifo Klaudio
Published: September 2023

Merger and Acquisition decisions are about timing, opportunity, and decision. In the business world,

these three words are partially influenced by the strength of the stock market. The timing is when the

stock market is highly valued which results in high stock valuation, after that is the opportunity which

means to find a target or if an existing target has lower stock valuation and finally comes the decision to

make whether to use cash or equity for the transaction. Since companies can use its stock as leverage to

acquire companies, a highly valued market gives the companies the resource with which to make purchases.

Therefore, the question arises whether the stock market influences the decision for companies

to engage in M&A transactions. This question is addressed in this study using a relatively large panel

data of M&A activity for the period 2008-2017. The econometric tool used in this study is regression

analysis. The measurement that this study used to value the stock market is by measuring the stock

market capitalization to GDP ratio of a country. The results displayed that the stock market to GDP ratio

is statistically significant at 5% risk on the M&A activity and with a 1% increase in the stock market

we expect a 0.1729% increase in the M&A activity. Additionally, the paper suggests the development of

a regression model that can measure the FDI inflows in Albania, and this is achieved by adjusting the

regression model variables in order to become more suitable for its economy.
Aalen’s additive Hazard model: an application in analyzing job tenure factors in private and public companies in Albania
Authors: Basha Lule , Puka Llukan
Published: September 2023

There are several statistical methods for time to event analysis, among which is the Cox proportional hazards model, that is most commonly used. In this model, the effect of the covariates is assumed to act multiplicatively on the baseline hazard rate and the ratio of the hazards is constant over survival time. However, when the proportionality assumption for the Cox proportional hazards model is not satisfied, an additive hazard regression model may be more appropriate. In this study, we give an overview of this approach and then apply Aalen’s additive hazard regression model to a data set which contain the job tenure for Albanian employees and variables that are thought of as important factors in the job tenure. The Aalen model allows for time-varying covariate effects and is used to assess the impact that age of the employee, the age at which he started the job, salary, gender, position and years of work in front of the current position may have in job termination.
Editorial
Authors: Tizard John
Published: September 2023

.
Uso medicinal y conocimientos ancestrales de Monnina crassifolia (Bonpl.) Kunth; Polygalaceae
Authors: López María Fernanda , Mera Moraima C. , Cañamar Luz M. , Haro Luis
Published: September 2023

Las enfermedades de alopecia o del cabello ocupan el segundo lugar dentro de las 15 más conocidas en afecciones capilares en Ecuador, que es uno de los países con mayor diversidad biológica y cultural. Los usos medicinales de las plantas juegan un papel importante en el bienestar de la población urbana y rural, por tal razón, las prácticas de los conocimientos ancestrales son las opciones terapéuticas más utilizadas en los sectores rurales de la Sierra Norte. El objetivo de esta investigación fue la identificación de las plantas de uso ancestral utilizadas para el tratamiento de enfermedades del cabello. El estudio se lo realizó en la comunidad de Angochagua, ubicada en la Provincia de Imbabura, Ecuador. Dentro de los participantes se tuvo a personas adultas, 22 hombres y 37 mujeres, que tienen conocimientos sobre plantas medicinales. El rango de edad de los informantes hombres fue de 15 a 85 años, mientras que las mujeres estuvieron en un rango de edad de 21 a 78 años. La información se obtuvo con previo consentimiento informado, además, se realizó entrevistas y encuestas, en las cuales se desarrolló el cuestionario U-PlanMed. Entre los resultados se identificaron tres especies de plantas y sus aplicaciones terapéuticas en enfermedades del cabello. Como conclusión de la investigación se tiene que el 80% de la población utilizó plantas medicinales para el tratamiento de afecciones del cabello, siendo las más usadas la Monnina crassifolia (Ivilán), Aloe vera (sábila), Salvia rosmarinus (romero).
El consentimiento tácito del donante cadavérico en salvaguarda del Derecho a la Salud Pública: Una mirada desde el estado del arte
Authors: Vásquez Flores Betty , Ludeña González Gerardo Francisco , Cueva Quezada Nilton Isaías
Published: September 2023

El objetivo fue analizar la regulación jurídica del consentimiento tácito de donante cadavérico y asegure el derecho a la salud mediante el estado del arte. Es de tipo básico y de enfoque cualitativo, se realizó un análisis documental, mediante una revisión bibliográfica, la búsqueda de información se obtuvo de publicaciones indexadas en Latinoamérica y Europa en las bases de datos de Ebsco, Scopus, Scielo, Redalyc y Dialnet, durante el período 2016 al 2023. Poca implementación de políticas públicas que ayuden a privilegiar el consentimiento presunto de donante cadavérico en salvaguarda de la salud pública. Conclusión, el consentimiento presunto de donante cadavérico contrarresta la alta demanda de órganos y la responsabilidad del Estado en el derecho de la salud pública, además, aún existe oposición por parte de sus familias, a pesar del consentimiento tácito del donante a fin de brindar una calidad de vida al receptor de la donación.
Nota Editorial
Authors: De Vincenzi Marcelo , Pons Claudia
Published: September 2023

Esta edición de la revista RAIA contiene, en primer lugar, una reseña del Congreso Internacional en Innovación Tecnológica Informática - XIX CIITI 2021, organizado por la Facultad de Tecnología Informática y su Centro de Investigación, CAETI, de la Universidad Abierta Interamericana, UAI. El mismo se desarrolló de forma virtual en la plataforma del congreso el jueves 30 de septiembre de 2021.
Certamen de Trabajos Estudiantiles XII CIITI-TE 2021
Authors: Pons Claudia
Published: September 2023

El Certamen de Trabajos Estudiantiles (XII CIITI-TE) es un espacio de encuentro destinado a fomentar la interacción de los estudiantes de grado y posgrado de las universidades argentinas. El certamen permitió el intercambio de ideas y experiencias y brindó un medio adecuado para la difusión de la producción intelectual que los estudiantes realizan en el marco de sus carreras universitarias. En este certamen participaron 22 trabajos provenientes de alumnos de distintas universidades del país. Los mejores trabajos de cada categoría fueron expuestos durante el congre- so en formato de poster y luego de su evaluación por parte de un Comité de expertos, los mejores trabajos fueron seleccionados y recibieron premios. Los trabajos premiados fueron los siguientes:
PBF-EB For Manufacturing Of 3D Metal-Metal Multi Material Assemblies
Authors: Botero Carlos , Sjöström William , Jimenez-Piqué Emilio , Şelte Aydın , Rännar Lars-Erik
Published: September 2023

Most Powder Bed Fusion (PBF) methods for the Additive Manufacturing (AM) of metals are based on the melting of powder of one specific metallic material; either of pure-elemental or pre-alloyed composition. Although the potential to build components from different materials in AM has recently gained a lot of attention, it is still not feasible in the current metal PBF systems. In the specific case of Electron beam- based PBF (PBF-EB), it is possible to precisely control the beam parameters in each site of the build area, which opens great possibilities for adaptive processes that allows melting powders of different nature in the same build. In this investigation, different steel-based and Ti6Al4V alloy powders are used to create metal-metal assemblies. By steering the fetching of two powders loaded in different hoppers it was possible to build different metal-metal assemblies. The microstructure and mechanical properties of the final materials were evaluated.
Influence Of Powder Packing Density On Binder Saturation And Wetting Behavior In Metal Binder Jetting
Authors: Reineke Lea , Schlegel Regina , Hein Sebastian
Published: September 2023

Metal Binder Jetting (MBJ) has an increasing attention in additive manufacturing because of its serial production potential. Finding the most suitable parameterization in MBJ and develop pre-printing tests, can reduce the iteration stages in material-specific process development, which saves costs, effort as well as material resources and printing capacity. The powder binder interaction of five powders at different packing densities were determined and the wetting behaviors were compared. The equilibrium saturation, the wetting rate and the initial wetting time were analyzed. In order to understand the nature of the resulting porosity at low packing density, various samples were sintered and compared by micrographs. The results show that an increasing packing density decreases the initial wetting time, increases the equilibrium saturation and lowers the saturation rate. The relationship between wetting behavior and printing parameters, as well as the effect of drying must be investigated further in subsequent studies.
Influence Of Different Heat Treatments On Mechanical Properties, Corrosion Resistance And Polishability For LPBF Manufactured Stellar® X15TN Stainless Tool Steel
Authors: Vikner Peter , Egea Philippe , Michel Loic , Joffre Thomas , Garabedian Stephane , Langer Lukas , Legay Florence
Published: September 2023

Stellar®X15TN (1.4123 / ASTM F899) is a nitrogen alloyed, cobalt free 0,4% C martensitic stainless steel which is easy to print by LPBF despite its relatively high carbon content. The steel combines a capability to be heat treated to over 58 HRC with an excellent corrosion resistance and a good polishability. Being magnetic and relatively soft in its as built and stress relieved state it is easy to machine, which is necessary for example for drilling and threading of fixation holes. The fact that it is cobalt free is another important feature due to health concerns. Therefore, Stellar® X15TN is suitable for additive manufacturing of plastic injection molds with conformal cooling, surgical tools, cutting tools for food and pharma processing but also for other components where a combination of high hardness and corrosion resistance is requested such as bearing and valve components. Nitrogen enhances the hardness and the wear resistance of the material through formation of carbonitrides. It is also an austenite stabilizing element that reduces the martensite start (Ms) and finish (Mf) temperatures which improves the printability. Finally, nitrogen has a positive impact on corrosion resistance. The challenge is to add nitrogen and to not lose it during the additive manufacturing. Previous studies have exposed the printing parameters. This work presents different heat treatments and their impact on the main usage properties such as hardness and impact strength.
Synthesis And Microstructural Changes During Heat Treatment Of SLM Aisi10mg Alloy
Authors: Nagode Aleš , Velikajne Nejc , Veber Anemarie , Paulin Irena , Zorc Matija , Kosec Borut , Zorc Borut , Bizjak Milan
Published: September 2023

AlSIMg10 is a heat-treatable hypoeutectic alloy with good castability and weldability, which makes it interesting for additive manufacturing (AM). In the present work, selective laser melting (SLM) technology was used to fabricate samples of AlSi10Mg alloy. One of the main challenges, however, is to produce an alloy with good microstructural homogeneity and as little porosity, residual stresses and cracks as possible. The main objective of this experimental research was to find the optimal process parameters for the fabrication of AlSiMg10 samples by SLM, which have a suitable microstructure and mechanical properties. Since defects in microstructure are usually due to inadequate process parameters, the effect of laser power and scanning speed were studied. Microstructural analysis was performed using LM and SEM/EDS. The changes in microstructure during post-processing heat treatment were followed in-situ by thermoelectrometric measurements based on electrical resistivity.
Dense Complex Copper Parts Obtained By Binder Jetting And Spark Plasma Sintering
Authors: Lagos M. A. , Azurmendi N. , Lores A. , Leizaola I. , Agote I.
Published: September 2023

Binder Jetting is capable of cost-effectively producing complex metal and ceramic components without the need for support structures. However, printed parts typically contain porosity due to the use of coarse powders and a loosely packed powder bed. For some materials, it is difficult to achieve full density without infiltration of a secondary lower melting point material. This work presents the post-densification of binder jetting parts by a pressure assisted sintering process, Spark Plasma Sintering. Sacrificial powder was used in other to maintain the complex geometry. Copper pieces were successfully densified using different starting conditions. However, densification of the pieces was not isotropic, and thus some design considerations are explained in order to obtain the right geometry. Additionally, considerations about the possible scalability and industrial application of this approach are also presented.
Association between XmnI Polymorphism and HbF Level in Sickle Cell Disease Patients from Chhattisgarh
Authors:   Department of Biochemistry, Pt. J. N. M. Medical college, Raipur, Chhattisgarh, India, Bhagat Sanjana , Thakur Amar Singh ,   Department of Biochemistry, Govt. Medical college, Jagdalpur, Chhattisgarh, India, Patra Pradeep Kumar ,   Department of Biochemistry, Pt. J. N. M. Medical college, Raipur, Chhattisgarh, India
Published: September 2023

The γG-158 (C-T) polymorphism plays important function in the disease severity of sickle cell anemia.The XmnI restriction site at -158 position of the γG-gene is associated with increased expression of the γG-globin gene and higher production of HbF. This study aims to determine the frequency of the different genotypes of the γG Xmn I polymorphism in sickle cell anemia and sickle cell trait patients in Chhattisgarh and its association with high HbFlevel. The Xmn1 polymorphic site was determined by PCR-RFLP procedure. XmnI polymorphism were studied in 100 sickle cell patients (SS), 50 sickle cell trait(AS) and 50 controls individuals (AA). The presence of XmnI (+/+) site in SS and AS patients associated with the increase of HbF (P<0.0001) synthesis. we also find that presence of one XmnI (+/-) site in SS patients compared with XmnI-/- site had not shows difference in HbF level.Polymorphic association is foundbetween presence and absence of XmnI site with HbF level, in AS and AA individuals.
Multiple Sites of Type II Site Ligand (Luteolin and BMHPC) Regulation of Gene Expression in PC-3 Cells
Authors:   Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA, Markaverich Barry M. , Vijjeswarapu Mary
Published: September 2023

Type II [3H]estradiol binding site ligands including luteolin (a naturally occurring bioflavonoid) and synthetic compounds such as 2,6-bis((3-methoxy-4-hydroxyphenyl)methylene)cyclohexanone (BMHPC) inhibit normal and malignant prostate cell (PC-3, LNCaP, DU-145) proliferation in vitro and in vivo. Type II sites represent a binding domain on histone H4 possibly involved in an epigenetic mechanism for controlling gene transcription. Treatment of PC-3 human prostate cancer cells with luteolin or BMHPC modulated the expression of a number of genes in the epidermal growth factor receptor signaling pathway (EGFRSP) and cell cycle pathway (CCP). Pronounced stimulation (400-2000% of control) of c-FOS and p21 RNA expression was observed, suggesting that these were primary sites of action. Both compounds also caused irreversible G2/M arrest (p<0.001). siRNA's for c-FOS or p21 reduced the RNA expression of their respective targets by 85-95%, with minimal effects on cell proliferation. Furthermore, neither siRNA alone (single knockdown), or in combination (double knockdown), blocked luteolin or BMHPC inhibition of PC-3 cell proliferation. Thus, although c-FOS and p21 are known to modulate the expression of genes in the ESGRSP (EGFR, SOS, GRB2, JNK1, MKK4, RasGAP) and CCP (CCNA2, CCNE2, CDC25A, CDKN1A, CDKN1B, p27, PLK1) involved in the regulation of cell proliferation by luteolin and BMHPC, the c-FOS and p21 siRNA knockdown studies reported here suggest that c-FOS and p21 may be secondary bystanders in the overall response to these ligands in the regulation of PC-3 cell proliferation.
Comparative Pharmacology and Toxicology of Tramadol & Tapentadol
Authors: Siddiqui Sarwar Naseer
Published: September 2023

Pain is a common symptom in various health conditions and can significantly impact a person's quality of life if not managed properly. Although non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are widely used for mild to moderate pain, they may not suffice for moderate to severe pain requiring combination therapy. In such cases, synthetic drugs like Tramadol and Tapentadol offer effective pain relief with improved safety profiles. This article aims to compare the pharmacokinetics, pharmacodynamics, and safety profiles of Tapentadol and Tramadol.

Tapentadol, a direct-acting synthetic opioid, demonstrates a reliable mode of action as it starts working upon reaching the bloodstream. In contrast, Tramadol requires metabolic conversion into active metabolites, resulting in a delayed onset of action. Furthermore, Tramadol's effectiveness is dependent on the presence of the CYP2D6 enzyme, with approximately 6% of Caucasians being deficient in this enzyme. Dosage adjustments may be required for individuals with impaired liver or kidney function.

Both Tapentadol and Tramadol primarily affect mu-opioid receptors (MOR), providing potent pain relief. However, Tramadol also inhibits the reuptake of noradrenaline and serotonin, while Tapentadol lacks an effect on serotonin. Tapentadol exhibits a higher affinity for MOR receptors, making it a more potent central acting painkiller compared to Tramadol. Nevertheless, Tapentadol's increased opioid activity increases the likelihood of mild and transient opioid-like side effects, such as drowsiness, constipation, and respiratory depression.

In terms of toxicology, both Tapentadol and Tramadol offer a safer alternative to morphine with reduced side effects. Tapentadol's greater opioid activity translates into a higher potential for opioid-related side effects, whereas Tramadol's serotonergic activity is associated with a higher incidence of vomiting and nausea. The absence of significant effects on CYP450 enzymes distinguishes Tapentadol from Tramadol, reducing the likelihood of drug interactions.

Overall, Tapentadol demonstrates several advantages over Tramadol, including faster onset of action, greater pain relief, and fewer side effects related to serotonergic activity. However, it is essential to consider that Tapentadol, although more effective, carries a higher probability of side effects associated with its increased opioid activity. Clinicians should carefully evaluate individual patient characteristics and requirements when selecting between these two medications for pain management.
Irritable Bowel Syndrome: The Functional Medicine Approach
Authors: Lacy Sandra , Prasad Kumar
Published: September 2023

Irritable bowel syndrome (IBS) is a complex functional gastrointestinal disorder with limited success in pharmacological therapy. The functional medicine approach aims to identify the root causes and personalize diagnosis and treatment. IBS is a chronic disorder characterized by abdominal pain, altered bowel movements, and other gastrointestinal symptoms. Diagnosing the condition remains challenging due to the lack of specific biomarkers or tests, resulting in frequent misdiagnosis.

The pathogenesis of IBS involves factors such as altered gastrointestinal motility, visceral hypersensitivity, intestinal barrier disorder, stress, dietary factors, small intestinal bacterial overgrowth (SIBO), changes in intestinal flora, low-grade mucosal inflammation, and genetic predisposition. The biopsychosocial model highlights the interaction between physiological and psychological factors.

The management of IBS involves a multidimensional approach tailored to each patient. Pharmacological therapy aims to alleviate symptoms but does not cure the condition. Non-pharmacological therapies, including dietary interventions, probiotic therapy, mind therapies, exercise, and complementary therapies, play a crucial role in IBS management.
Impact of Physical Activity on Prostate Cancer Incidence
Authors: Leitzmann Mark , Gronberg Michael
Published: September 2023

Prostate cancer is a leading cancer in men, with its incidence varying among different countries and ethnic groups. The introduction of serum prostate-specific antigen (PSA) testing has led to increased early detection rates, particularly in high Human Development Index (HDI) countries. Several extrinsic or modifiable factors have been implicated in the development of prostate cancer. Diet, including high meat and dairy consumption, alcohol intake, and dietary supplements, has shown inconsistent associations. Obesity has emerged as a significant risk factor for prostate cancer and can worsen prognosis and treatment outcomes. Conversely, consumption of fish and fish oil has been associated with a lower incidence and mortality rate of prostate cancer.

The relationship between physical activity and prostate cancer risk has been extensively studied, yielding mixed results. While physical activity has consistently shown protective effects against other cancers, its association with prostate cancer risk is less clear. Some studies suggest a potential benefit, particularly with vigorous physical activity, while others find no significant association. However, physical activity has demonstrated positive effects on survival rates and disease progression among men already diagnosed with prostate cancer.