bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulmonary arteriovenous fistula diagnosed by contrast echocardiography: a case report of a daughter and a mother
Authors: Pan Gaoyun , Dong Xinxin , Xu Jianguo
Published: March 2020

Background Pulmonary arteriovenous fistula is a rare disease with a direct connection between the pulmonary artery and the vein, and in most cases is congenital. In a proportion of patients, it can cause hypoxemia, cyanosis and dyspnea. The golden standard for the diagnosis of PAVF is pulmonary angiography. We experienced two cases of a daughter and a mother with PAVF diagnosed by contrast echocardiography, which is simple and sensitive for the detection of pulmonary arteriovenous fistula. Case presentation Case 1:A 22-year-old female was admitted to hospital because of "unconsciousness for 3 hours after sudden seizures".CT showed left frontal cerebral arteriovenous malformation with hemorrhage, a nodule of upper lobe of left lung, arteriovenous malformation possible.Intracranial hematoma removal, arteriovenous malformation resection were performed urgently. Postoperatively, the patient presented severe hypoxemia. Contrast echocardiography showed continuous dense bubbles were visualized in the left heart from the third heart cycle following imaging in the right heart, , suggesting pulmonary arteriovenous fistula. Case 2 : The mother of the first patient, 44-year-old female, with no history of dyspnea, cyanosis,and stroke, was medically screened for suspected pulmonary arteriovenous fistula due to her daughter’s disease. Contrast echocardiography also indicated pulmonary arteriovenous fistula. Conclusions Contrast echocardiography is an excellent tool for the detection of pulmonary arteriovenous fistula. Patients with suspected pulmonary arteriovenous fistula should be examined by chest radiography combined with contrast echocardiography as first line screening tests, especially in patients with severe condition.
Clinical presentation and management strategies for yolk sac tumor. A case series and review of the literature
Authors: Nie Caiyun , Lv Huifang , Xing Yishu , Song Tao , Feng Wen , Chen Beibei , chen Xiaobing
Published: March 2020

Background: Yolk sac tumor (YST), also known as endodermal sinus tumor, is a highly malignant germ cell-derived tumor. As a rare disease, the diagnosis, prognostic factors, and optimal management of yolk sac tumor are difficult. The present study aims to investigate the clinicopathological features and optimal management strategies of yolk sac tumor. Results: We retrospectively investigated seventeen patients with yolk sac tumor in our institute between January 2010 to December 2019. The median age of the study population was 24 years (range 6–50 years). Most cases were female (11/17, 64.7%). Among the seventeen cases of YSTs, 8 cases were ovarian YSTs, 3 cases were mediastinum YSTs, 2 cases were testis YSTs. 94.1% patients had a markedly raised AFP. Surgery and chemotherapy were the main treatment methods for YST and improved the prognosis of patients. Conclusions: YST is a highly malignant and rare germ cell tumor, ovarian YST is the most common type. Early diagnosis and reasonable treatment can improve the prognosis of YST. These cases highlight the tumor’s characteristics. As more experience is gathered with this rare malignant tumor, the more likely we are to cure this disease.
Crowd Counting Method Based on Cross-Source Multi-View and Multi-Granularity Video Fusion
Authors: Bai Liu , Wu Cheng , Lin Yufeng , Zhang Jin , Sheng Jie , Xie Feng , Wang Yiming
Published: March 2020

With the rapid growth of the world's population and the rapid development of urbanization, the issue of crowd gathering safety has aroused widespread concern in society. Extensive video surveillance systems provide rich data support for dense crowd management. Video-based crowd counting and density estimation methods are the core technologies to ensure the safety of crowd gathering. Different from single-view video analysis, cross-source multi-view multi-granularity video contains more cross-information. The complementary sharing of information is of great help to solve the problems such as occlusion in the current crowd counting. Therefore, this article proposes a crowd counting method based on cross-source multi-view and multi-granularity video distributed information fusion. By establishing a distributed structure from different cameras that matches low-altitude and high-altitude views, it uses fine-grained from low-altitude images. The high-resolution local information corrects and supplements the global information from high-altitude images, so as to calculate a more accurate and global number and density of people. This method is actually applied to the landmark building of Suzhou Life City Square. The changes in the number of people and the movement situation during the evacuation are analyzed and evaluated, and good results are obtained.
Effectiveness of message framing to improve oral health behaviors and dental plaque among pregnant women
Authors: Araban Marzieh , Divdar Masoumeh , Cheraghian Bahman , Heidarabadi Akbar Babaei
Published: March 2020

Background: Health messages can play an important role in motivating people to improve their health-related behaviors. The purpose of the present study was to investigate the effectiveness of message-framing on oral health-related behaviors and dental plaque among pregnant women. Methods: This quasi-experimental study was conducted on 104 pregnant women in Izeh, Iran in 2017. Participants were randomly divided into three groups; gain-framed, loss-framed and control groups. The research instrument included a demographic form along with the constructs of knowledge, attitude, behavioral intention, self-efficacy, performance, and dental plaque index derived from previous studies. Moreover, gain- and loss-framed messages were sent to the intervention groups via cell phones but the control group did not receive any messages in this regard. The participants’ dental plaque was also examined within two steps( at baseline and 8-weeks follow-up) by a dentist. The significance level of the tests was considered by p<0.05. Results: The mean scores of knowledge, attitude, behavioral intention, and self-efficacy had significantly increased in the gain- and loss-framed intervention groups; (gain-framed knowledge(6.05±1.90;CI:5.40-6.71); attitude(5.00±3.61;CI:3.75-6.24); behavioral intention (2.91±1.59;CI:2.36-3.46), and self-efficacy (4.42±2.69;CI:3.50-5.35), loss-farmed knowledge (5.71±1.52;CI:5.19-6.23), attitude (4.54±2.67;CI:3.62-5.46), behavioral intention (2.25±1.94;CI:1.58-2.92), and self-efficacy (3.97±2.60;CI:3.07-4.86) (p<0.001) as compared to the control group; but no significant difference was observed in the control group (knowledge (0.38±1.45;CI:0.12-0.89, p=0.135); attitude (0.88±3.63;CI:0.38-2.14, p= 0.166); behavioral intention (-0.38±1.74;CI:-0.98-0.22 , p=0.2); self-efficacy (.0.50±3.23;CI:-1.62-0.62, p=0.37) ). The rising trend in the mean score of the behaviors in the intervention groups was significantly higher than that in the control group (p<0.001). The percentage of dental plaque in the gain- and loss-framed intervention groups also showed a significant decrease compared with that in the control group (gain-framed dental plaque (16.46±11.66;CI:12.46-20.47, p<0.001); loss-framed dental plaque (15.06±8.52;CI:12.13-17.99, p<0.001). Conclusion: The results showed that message-framing could enhance knowledge, attitude, behavioral intention, self-efficacy, and performance regarding oral health, also it could reduced dental plaque in the intervention groups as compared to the control group. Meanwhile, no significant difference was observed in terms of the effectiveness of the loss- or gain-framed messages in these construct. The results might help health practioners to develop tailored oral health promoting messages for pregnant women.
Understanding Digital Media
Authors: Verständig Dan , Holze Jens
Published: March 2020

Ausgehend davon, dass digitale Medien konstitutiv für soziale und kulturelle Räume sind, thematisiert der Beitrag thesenartig zwei zentrale Aspekte der erziehungswissenschaftlichen Online-Forschung. Zum einen wird die Bedeutung von onlineethnografischer Forschung im Horizont digitaler Medialität diskutiert, die als eine Methodologie den Blick auf die Formstrukturen von digitalen Medien und deren kulturellen und sozialen Rahmungen ermöglicht. Zum anderen erfordert der Umgang mit digitalen Daten eine methodische und methodologische Reflexivität hinsichtlich ihrer strukturellen Einbettung und Beschaffenheit. Hierbei wird gezielt auf die Frage abgezielt, wie man mit den technologischen Infrastrukturen überhaupt umgeht und welche Rolle nicht nur Daten, sondern auch digitale Methoden für die Erziehungswissenschaft spielen. Beide Thesen stehen in einer Wechselbeziehung. Es geht im Beitrag darum, die Verschränkungen deutlich zu machen und für einen reflexiven Umgang mit digitalen Daten, Methoden und Methodologien zu plädieren.
Petrographic and spectral study of hydrothermal mineralization in drill core from Hawaii: A potential analog to alteration in the martian subsurface
Authors: Calvin Wendy M. , Lautze Nicole , Moore Joe , Thomas Donald , Haskins Eric , Rasmussen Brandon P.
Published: March 2020

Continuous rock core was collected for 1764 m (5786’) on the Pohakuloa Army Training base near the center of the big island of Hawaii. The core traverses basaltic lava flows from the volcano's shield-building phase, and perched aquifers and higher temperature groundwaters were encountered. The collected samples record water-rock interactions of basaltic materials in a setting that may be a model for groundwater interactions on Mars. We collected visible and infrared point spectra of materials in the lowest portion of the core, where alteration was noted to become more prominent. We identified three types of phyllosilicate spectral signatures and three types of zeolites. The phyllosilicates show similarity to those identified on Mars using data from the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM). Based on the field survey, 25 depths were selected for sampling and petrographic analysis of thin sections. The spectral data and thin section work have a strong agreement in the types of materials identified by the two different techniques. Both the spectral and petrographic data indicate low to moderate temperature geothermal alteration occurred in the lower half of the core. The field spectra are a useful reconnaissance tool for selecting mineralogic diversity for subsequent higher resolution and more time-consuming laboratory analysis.
Research Progress on the Catalytic Enantioselective Synthesis of Axially Chiral Allenes by Chiral Organocatalysts
Authors: Li Qing Han , Jiang Xin , Wu Kun , Luo Rui Qiang , Liang Meng , Zhang Zhi Hao , Huang Zhe Yao
Published: March 2020

Chiral allenes are important structural scaffolds found in many natural products
and drugs, and in addition, they also serve as building blocks for many organic transformations.
The conventional methods for preparing chiral allenes rely on the resolution of
racemic allenes and the chirality transfer between non-racemic propargylic derivatives and
nucleophilic reagents. In recent years, the synthesis of chiral allenes by asymmetric catalysis
has been achieved fruitful results. Among them, enantioselective synthesis of chiral
allenes with chiral organic catalysts is particularly prominent. In this paper, the research
progress of enantioselective synthesis of chiral allenes catalyzed by chiral organic catalysts
in recent years is reviewed, including various reaction systems and synthesis applications.
Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis
Authors: Liessi Nara , Pesce Emanuela , Salis Annalisa , Damonte Gianluca , Tasso Bruno , Cichero Elena , Pedemonte Nicoletta , Millo Enrico
Published: March 2020

Background:

Cystic fibrosis (CF) is the autosomal recessive disorder most common in
Caucasian populations. It is caused by mutations in the cystic fibrosis transmembrane regulator
protein (CFTR). CFTR is predominantly expressed at the apical plasma membranes of the epithelial
cells lining several organs, and functions as a cAMP-regulated chloride/bicarbonate channel.
To address the underlying causes of cystic fibrosis, two biomolecular activities are required,
namely correctors to increase CFTR levels at the cell surface, and potentiators to allow the effective
opening of the CFTR channel.

Objective:

In our previous data, we demonstrated that some aminoarylthiazoles (AATs) have peculiar
activity acting as correctors and as potentiator-like molecules.

:

Curiously, a compound called 1 has been shown to be markedly active as a potentiator. Now, we
have further modified its scaffold at different portions, for the identification of molecules with improved
potency and effectiveness on mutant CFTR.

Methods:

Starting from this active compound, we synthesized a small library trying to improve the
activity as potentiators. To extrapolate the contribution of a particular structural portion to bioactivity,
we selectively modified one portion at a time.

Results:

Our study has provided a structure-activity relationship (SAR) on AATs and led to the
identification of some compounds, with a particular ability to act as CFTR potentiators.

Conclusion:

Two compounds 2 and 13 appear to be promising molecules and could be used for
the future development of potentiators of the chloride transport defect in cystic fibrosis.
Leyes y políticas sobre el aborto: retos y oportunidades
Authors: Cook Rebecca J.
Published: March 2020

Leyes y políticas sobre el aborto: retos y oportunidades
La que con discutidoras sobre abortos se junta...
Authors: Ortega Adriana
Published: March 2020

La que con discutidoras sobre abortos se junta...
Pero no te extraño (Opus 112)
Authors: Felipe Liliana
Published: March 2020

Pero no te extraño (Opus 112)
El cuerpo femenino
Authors: Atwood Margaret , Mansour Mónica
Published: March 2020

El cuerpo femenino
La vejez
Authors: De Beauvoir Simone , Mansour Mónica
Published: March 2020

La vejez
Llanto
Authors: Boullosa Carmen
Published: March 2020

Llanto
El cine de las mujeres: una mirada a la identidad femenil
Authors: Melchiori Paola , Mendiola Salvador
Published: March 2020

El cine de las mujeres: una mirada a la identidad femenil
Thelma y Louise: el prestigio de las mujeres
Authors: Schnaith Nelly
Published: March 2020

Thelma y Louise: el prestigio de las mujeres
La invención de la soledad
Authors: Campbell Federico
Published: March 2020

La invención de la soledad
Russell, Berkeley y la materia objetiva
Authors: Sosa Ernesto
Published: March 2020

Resumen
Conceptos de sustancias y conceptos de propiedades en animales no humanos
Authors: Danón Laura
Published: March 2020

El presente trabajo tiene dos objetivos centrales. Primero caracterizaré una variante de pragmatismo conceptual según la cual algunos conceptos deben entenderse como habilidades para identificar sustancias e identificar propiedades del entorno, y mostraré que quien cuenta con esas dos habilidades satisface, en grados diversos en cada caso, distintos requisitos centrales para la posesión de conceptos. Posteriormente defenderé la viabilidad de extender este enfoque a los animales no humanos, apelando a evidencia empírica que indica que distintas especies son capaces de identificar sustancias de su entorno y que sugiere la presencia de habilidades para identificar propiedades en algunos primates y pájaros.
REKOGNISI DALAM MEREPRESENTASIKAN SIMBOL TURUNAN PARSIAL SEBAGAI METONYMY DAN METAPHOR
Authors: Zukhrufurrohmah Zukhrufurrohmah , Putri Octavina Rizky Utami
Published: March 2020

Representasi simbol melibatkan metonymy dan metaphor. Metonymy sebagai rantai penanda, dalam hal ini simbol, sedangkan metaphor sebagai pemaknaan dari penanda (simbol). Metonymy dan metaphor saling terkait dan terlibat dalam sistem penyimbolan saat seseorang menemukan simbol baru dalam proses pembelajaran matematika. Mahasiswa Teknik Sipil banyak menemukan simbol baru dalam perkuliahan Kalkulus II, seperti simbol fungsi dua variabel atau lebih beserta turunannya. Simbol-simbol tersebut tentunya berbeda dengan simbol fungsi satu variabel dan turunannya yang telah dipelajari pada Kalkulus I semester sebelumnya. Penelitian ini bertujuan untuk mendeskripsikan kemampuan mahasiswa Teknik Sipil dalam merepresentasikan simbol sebagai metonymy dan metaphor melalui penyelesaian masalah Turunan Parsial. Penelitian ini merupakan penelitian studi kasus, sebagai salah satu upaya untuk mendeteksi kesulitan mahasiswa dalam belajar Turunan Parsial. Mahasiswa diberi worksheet berisi masalah Turunan Parsial yang difokuskan pada representasi simbol sebagai metonymy dan metaphor. Hasil penyelesaian masalah pada worksheet dianalisis berdasarkan representasi simbol turunan parsial baik dari notasinya maupun makna dari notasi. Hasil yang diperoleh adalah bahwa mahasiswa Teknik Sipil kurang mampu dalam merepresentasikan simbol turunan parsial fungsi f terhadap x maupun y. Mahasiswa mampu menentukan selesaian akhir turunan parsial dengan benar, namun kurang baik dalam penandaan simbol turunan parsial.
Gökkuşağı Alabalığı (Oncorhynchus mykiss)’ndan Elde Edilen Balık Köftelerinde Biberiye ve Defne Uçucu Yağlarının Mikrobiyolojik ve Duyusal Kaliteye Etkisi
Authors: Keser Ergül , İzci Levent
Published: March 2020

Bu çalışmada, gökkuşağı alabalığı (Oncorhynchus mykiss)’ndan elde edilen balık köftelerinin mikrobiyolojik ve duyusal özellikleri üzerine biberiye ve defne uçucu yağlarının etkileri araştırılmıştır. Gökkuşağı alabalığı filetoları kıyma haline getirilmiş ve farklı katkı maddeleri ilave edilerek kontrol grubu (Kk), biberiye uçucu yağı ilave edilmiş grup (Bk) ve defne uçucu yağı ilave edilmiş grup (Dk) olmak üzere üç balık köftesi grubu oluşturulmuştur. Tüm köfte örnekleri 4±1oC’de muhafaza altına alınarak periyodik olarak mikrobiyolojik ve duyusal olarak değerlendirilmiştir. Araştırma sonuçlarına göre, çiğ balık etinde toplam mezofilik aerobik bakteri (TMAB) sayısı 5,24±0,04 log kob/g, toplam psikrofilik aerobik bakteri (TPAB) sayısı 4,22±0,02 log kob/g olarak belirlenmiştir. Çiğ balık etindeki TMAB ve TPAB sayısı köfte yapımıyla birlikte tüm köfte örneklerinde (Kk, Bk ve Dk) azalmış, Dk grubu köfte örneklerinde TPAB için, Bk grubu köfte örneklerinde TMAB ve TPAB için bu azalma örneklerde istatistiksel olarak önemli bulunmuştur (P<0,05). Panelistlerin 1. gün değerlendirmesi sonucunda Bk ve Dk köfte örneklerinin genel beğenisinin Kk köfte örneklerine göre daha iyi olduğu belirlenmiştir. Tüm köfte grupları içerisinde Dk köfte örneklerinin genel olarak panelistlerce daha fazla beğenildiği saptanmıştır.
Farklı Konsantrasyonlarda Kullanılan Nisinin Soğukta (4±2oC) Depolanan Levrek (Dicentrarchus labrax) Filetolarının Yağ Asitleri Üzerine Etkileri
Authors: Uçar Yılmaz , Özoğul Fatih
Published: March 2020

Bu çalışmada, farklı konsantrasyonlarda (% 0.2, % 0.4 ve % 0.8) kullanılan nisinin soğukta depolanan levrek (Dicentrarchus labrax) filetolarının yağ asitleri üzerine etkileri araştırılmıştır. Yapılan yağ asidi analizleri sonucunda yüksek oranlarda tespit edilen doymuş yağ asitleri (SFA) miristik asit (C14:0), palmitik asit (C16:0), stearik asit (C18:0) olarak belirlenmişken, yüksek oranlarda belirlenen tekli doymamış yağ asitleri (MUFA) palmitoleik asit (C16:1), oleik asit (C18:1n9), vaksenik asit (C18:1n7), eikosenoik asit (C20:1n9) olarak belirlenmiştir. Yüksek oranlarda tespit edilen çoklu doymamış yağ asitleri (PUFA) ise linoleik asit (C18:2n6), linolenik asit (C18:3n3), eikosapentaenoik asit (EPA, C20:5n3) ve dokosahekzaenoik asit (DHA, C22:6n3) olmuştur. İncelenen levrek balığının doymamış yağ asidi içerikleri açısından zengin besinsel değerlere sahip olduğu tespit edilmiştir. Nisin muamele gruplarının depolama sonundaki PUFA, MUFA ve SFA içeriği kontrol grubundan daha yüksek olduğu belirlenmiş ve bu durumun nisinin antioksidan özelliğinden kaynaklandığı sonucuna varılmıştır. Yağ asitleri kompozisyon analizi sonuçlarına göre, nisin varlığının balıkta lipit kalitesini koruduğu gözlenmiştir.
Tatlarin Baraj Gölündeki Su Kirliliğinin Carassius gibelio ve Carassius auratus Türlerine Genotoksik Etkisinin Mikronükleus Testi ile Belirlenmesi
Authors: Kutoğlu Selen , Çiçek Erdoğan
Published: March 2020

Bu çalışma Tatlarin Baraj Gölünün fiziko-kimyasal özelliklerini ortaya koymak ve kirliliğin balıklar üzerine genotoksik etkisini ortaya koymak amacıyla yapılmıştır. Çalışma Nisan 2013-Mayıs 2014 tarihleri arasında aylık periyotlarla yürütülmüştür. Ölçümü yapılmış olan fizikokimyasal parametrelere ait yıllık ortalama değerlerden; su sıcaklığı 15,5 °C, çözünmüş oksijen 6,44 mg/L, elektriksel iletkenlik 622,9 µmho/cm, toplam çözünmüş madde 0,519 mg/L (TÇM), tuzluluk 0,40 mg/L, pH 10,67, nitrit 0,77 mg/L, nitrat 1,14 mg/L, amonyak 2,67 mg/L, amonyum 1,54 mg/L, potasyum 17,56 mg/L, sülfat 63,7 mg/L, flor 0,57 mg/L, klor 48,23 mg/L, askıda katı madde (AKM) 44,75 mg/L, sertlik 10,82 mg/L, CaCO3 195,67 mg/L, fosfat 2,96 mg/L, kimyasal oksijen ihtiyacı (KOİ) 74,05 mg/L ve biyolojik oksijen ihtiyacı (BOİ) 12,5 mg/L olarak belirlenmiştir. Çalışma sonunda barajın Su Kirliliği Kontrol Yönetmeliği kirlilik sınıflamasına göre “çok kirli sular” kategorisine yakın olduğu sonucuna varılmıştır. Kirli suya sahip baraj gölünde yaşayan Carassius gibelio ve Carassius auratus’a ait mikronükleus frekansları ile kromozom anomalilerinden tomurcuklu nükleus, çentikli nükleus, loblu nükleus ve binükleus frekansları belirlenmiştir. Barajda yaşayan C. gibelio ve C. auratus türlerinin eritrositlerinde mikronükleus frekansı sırasıyla 6,12±3,61 ve 5,57±2,3 olarak belirlenmiştir. Buna göre su kirliliğinin balıklar üzerinde genotoksik etki gösterdiği sonucuna varılmıştır.
‘It’s cowboy country up there’: Ruination and Ruinenlust in the wilds of Broughton
Authors: Joanne Scott
Published: March 2020

This article articulates and reflects on dual practices that arise from concurrently responding to my home locality through creative research and resident action. It considers these parallel practices through the dual notions of wildness and ruins/ruination. The critical writing is punctuated with artefacts of both practices, generating a mode of intermedial writing that, through placing these elements and critical reflection in direct conversation, allows feeling-thoughts to emerge about the process of researching a locality in which you are embedded, as well as the wild and ruined features of contemporary urban landscapes.
Impact of Demographical Factors on Work Life Balance among Academic Staff of University of Kelaniya, Sri Lanka
Authors: Padmasiri M.K.D. , Mahalekamge W.G.S.
Published: March 2020

The focus of this research is to find out the impact of demographical factors on Work Life Balance among academic staff of University of Kelaniya. Objective is examining the impact of selected demographical factors; gender, marital status and investigate best and worst gender level and marital status of Work Life Balance. Research sample consists with 150 lecturers out of 560 lecturers in University of Kelaniya. Based on random sampling method standardized questionnaires are distributed to collect data. Based on the analysis researchers identified that there is significant relationships among gender, and marital status and Work Life Balance excluding age as a demographic factor. Further identified females as a best group in Work Life Balance and under marital status single group is having Work life Balance greater than married group. Based on findings researchers established that there is a significant impact of gender and marital status on Work Life Balance as demographic factors.
Effects of Vitamin D Receptor Knockout and Vitamin D Deficiency on Corneal Epithelial Wound Healing and Nerve Density in Diabetic Mice
Authors: Lu Xiaowen , Vick Sarah , Chen Zhong , Chen Jie , Watsky Mitchell A.
Published: March 2020

Diabetic keratopathy occurs in ∼70% of all people with diabetes. This study was designed to examine the effects of vitamin D receptor knockout (VDR−/−) and vitamin D deficiency (VDD) on corneal epithelial wound healing and nerve density in diabetic mice. Diabetes was induced using the low-dose streptozotocin method. Corneal epithelial wounds were created using an Algerbrush, and wound healing was monitored over time. Corneal nerve density was measured in unwounded mice. VDR−/− and VDD diabetic mice (diabetic for 8 and 20 weeks, respectively) had slower healing ratios than wild-type diabetic mice. VDR−/− and VDD diabetic mice also showed significantly decreased nerve density. Reduced wound healing ratios and nerve densities were not fully rescued by a supplemental diet rich in calcium, lactose, and phosphate. We conclude that VDR−/− and VDD significantly reduce both corneal epithelial wound healing and nerve density in diabetic mice. Because the supplemental diet did not rescue wound healing or nerve density, these effects are likely not specifically related to hypocalcemia. This work supports the hypothesis that low vitamin D levels can exacerbate preexisting ophthalmic conditions, such as diabetes.
Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth
Authors: Sun Jinhong , Xiong Yi , Li Xin , Haataja Leena , Chen Wei , Mir Saiful A. , Lv Li , Madley Rachel , Larkin Dennis , Anjum Arfah , Dhayalan Balamurugan , Rege Nischay , Wickramasinghe Nalinda P. , Weiss Michael A. , Itkin-Ansari Pamela , Kaufman Randal J. , Ostrov David A. , Arvan Peter , Liu Ming
Published: March 2020

Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant INS gene–induced diabetes of youth (MIDY). How these abnormal interactions are initiated remains unknown. Normally, PI-WT dimerizes in the ER. Here, we suggest that the normal PI-PI contact surface, involving the B-chain, contributes to dominant-negative effects of misfolded MIDY mutants. Specifically, we find that PI B-chain tyrosine-16 (Tyr-B16), which is a key residue in normal PI dimerization, helps confer dominant-negative behavior of MIDY mutant PI-C(A7)Y. Substitutions of Tyr-B16 with either Ala, Asp, or Pro in PI-C(A7)Y decrease the abnormal interactions between the MIDY mutant and PI-WT, rescuing PI-WT export, limiting ER stress, and increasing insulin production in β-cells and human islets. This study reveals the first evidence indicating that noncovalent PI-PI contact initiates dominant-negative behavior of misfolded PI, pointing to a novel therapeutic target to enhance PI-WT export and increase insulin production.
Trends in Bone Mineral Density, Osteoporosis, and Osteopenia Among U.S. Adults With Prediabetes, 2005–2014
Authors: Chen Chi , Chen Qi , Nie Bin’en , Zhang Haojie , Zhai Hualing , Zhao Li , Xia Pu , Lu Yingli , Wang Ningjian
Published: March 2020

OBJECTIVE

We aimed to evaluate trends in bone mineral density (BMD) and the prevalence of osteoporosis/osteopenia in U.S. adults with prediabetes and normal glucose regulation (NGR) and further investigate the association among prediabetes, osteopenia/osteoporosis, and fracture.

RESEARCH DESIGN AND METHODS

We collected and analyzed data from the U.S. National Health and Nutrition Examination Surveys during the period from 2005 to 2014. Femoral neck and lumbar spine BMD data were available for 5,310 adults with prediabetes and 5,162 adults with NGR >40 years old.

RESULTS

A shift was observed toward a lower BMD and a higher prevalence of osteopenia/osteoporosis at the femoral neck and lumbar spine in U.S. adults >40 years old with prediabetes since 2005, especially in men <60 and women ≥60 years old. A shift toward a higher prevalence of osteopenia/osteoporosis at the femoral neck was also observed in adults >40 years old with NGR. Moreover, prediabetes was associated with a higher prevalence of hip fracture, although participants with prediabetes had higher BMD and a lower prevalence of osteopenia/osteoporosis at the femoral neck.

CONCLUSIONS

There was a declining trend in BMD from 2005 to 2014 in U.S. adults >40 years old with prediabetes and NGR, and this trend was more significant in men <60 years old. Populations with prediabetes may be exposed to relatively higher BMD but a higher prevalence of fracture.
The Prognosis of Patients With Type 2 Diabetes and Nonalbuminuric Diabetic Kidney Disease Is Not Always Poor: Implication of the Effects of Coexisting Macrovascular Complications (JDDM 54)
Authors: Yokoyama Hiroki , Araki Shin-ichi , Kawai Koichi , Yamazaki Katsuya , Shirabe Shin-ichiro , Sugimoto Hidekatsu , Minami Masae , Miyazawa Itsuko , Maegawa Hiroshi
Published: March 2020

OBJECTIVE

Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing phenotype in patients with type 2 diabetes. However, it remains unclear whether its prognosis is poorer than that of other DKD phenotypes.

RESEARCH DESIGN AND METHODS

A total of 2,953 Japanese patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, enrolled in an observational cohort study in 2004, were followed until 2015. On the basis of albuminuria (>30 mg/g creatinine) and reduced eGFR (<60 mL/min/1.73 m2) at baseline, participants were classified into the four DKD phenotypes—no-DKD, albuminuric DKD without reduced eGFR, nonalbuminuric DKD with reduced eGFR, and albuminuric DKD with reduced eGFR—to assess the risks of mortality, cardiovascular disease (CVD), and renal function decline.

RESULTS

During the mean follow-up of 9.7 years, 113 patients died and 263 developed CVD. In nonalbuminuric DKD, the risks of death or CVD were not higher than those in no-DKD (adjusted hazard ratio 1.02 [95% CI 0.66, 1.60]) and the annual decline in eGFR was slower than in other DKD phenotypes. The risks of death or CVD in nonalbuminuric DKD without prior CVD were similar to those in no-DKD without prior CVD, whereas the risks in nonalbuminuric DKD with prior CVD as well as other DKD phenotypes were higher.

CONCLUSIONS

Nonalbuminuric DKD did not have a higher risk of mortality, CVD events, or renal function decline than the other DKD phenotypes. In nonalbuminuric DKD, the presence of macrovascular complications may be a main determinant of prognosis rather than the renal phenotype.
Peningkatan Keterampilan Berpikir Kritis dan Hasil Belajar Siswa SD dengan Menerapkan Strategi Everyone Is A Teacher Here pada Model Pembelajaran Kooperatif
Authors: Yusuf Mochamad
Published: March 2020

The purpose of this research was assess the activity of teachers, students, enhancement of critical thinking skils student,  results cognitive study, and to know student respon for learning that applied “Everyone  is a Teacher Here”strategy for cooperative models. Research used Classroom Action Research (CAR)methods. The subjects and the location of research was fourth grade students of  Hidayatul Mubtadiin Primary School, amounting to 26 students.The instrument used in this research consisted of sheet of observation teachers activities, sheets of observation of students avtivities, critical thinking skills test, cognitive results studies test, sheets of observation of afective results studies test, sheets of observation of psicomotoric results studies test, and sheets of respons students. The result showed that the activity of teacher, students, critical thinking skills, and the student’s results  study was increase significantly during two cycles with their respective percentage of completeness. Learning of applying “Everyone  is a Teacher Here” strategy for Cooperative models got positive respons from students so worthy to be applied by the teacher.
Upaya Meningkatkan Keaktifan Belajar Melalui Penerapan Model Students Divisions Achievement Divisions di XI IPS 1 SMANegeri 1 Bukittinggi
Authors: Mardian Wiky , Sylvia Ike
Published: March 2020

Penelitian ini bertujuan untuk mengetahui keaktifan siswa pada mata pelajaran sosiologi melalui penerapan model kooperatif tipe Students Teams Achievement Divisions di SMA Negeri 1 Bukittinggi. Penelitian ini dilatar belakangi oleh rendah nya tingkat keaktifan siswa kelas XI.IPS.1 dalam proses pemebelajaran sosiologi. Upaya untuk meningkatkan keaktifan siswa dengan menerapkan model Students Teams s Achievement Divisions. Jenis penelitian ini merupakan Penelitian Tindakan Kelas. Penelitian ini dilaksanakan sebanyak 2 siklus dalam 1 siklus terdapat 2 kali pertemuan dan setiap siklus terdapat 4 buah tahapan yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Subyek penelitian ini adalah siswa kelas XI.IPS.1 SMA Negeri 1 Bukittinggi yang berjumlah sebanyak 36 orang. Penelitian ini menggunakan instrumen lembar observasi yang berisi indikator keaktifan dalam belajar. Pada penelitian ini peneliti menetapkan tingkat keberhasilan dalam penelitian pada kategori baik yaitu 75% keatas. Hasil penelitian ini menunjukan adanya peningkatan keaktifan dalam belajar dengan penerapan model Students Teams Achievement Divisions. Dapat dilihat pada siklu I pertemuan pertama rata-rata skor keaktifan per indikator sebesar 62,36% dan pada silklus ke II pertemuan kedua sebesar 84,86%.
ESTIMATION OF THE GROWTH OF ‘VANDA’ MAIDEN SWEET CHERRY TREES ON THREE ROOTSTOCKS AND AFTER APLICATION OF FOLIAR FERTILIZATION IN A NURSERY
Authors: Świerczyński Sławomir , Borowiak Klaudia , Bosiacki Maciej , Urbaniak Magdalena , Malinowska Agnieszka
Published: March 2020

Cultivation of sweet cherry trees is growing in popularity in Poland thus there is an increasing demand for good quality nursery material. The growth of maiden sweet cherry trees of ‘Vanda’ depending on three rootstocks was compared within three years of the nursery experiment. Also the nutritional status as well as photosynthetic activity of maiden trees after the use of four foliar preparations were in the scope of interest. On the basis of the size of the trunk diameter and weight of maiden sweet cherry tree fresh mass as well as on the basis of dry mass of leaves, the strongest vigor of growth was observed on Colt rootstock, contrary to the vigor on GiSeLa 5 rootstock, in which it was the weakest. Maidens produced on Colt rootstock formed more lateral shoots in comparison to other rootstocks. After foliar fertilization, maiden sweet cherry trees growing on Colt rootstock did not show better parameters of growth, except for Maxi Grow Excel preparation that caused better results of growth. The influence of preparations used on the content of macro and microelements was differentiated. A positive effect of all preparations was noted as far as gas exchange parameters were concerned, especially in the case of Maxi Grow Excel.
PENINGKATAN KEMAMPUAN MEMBILANG 1 – 20 MELALUI PERMAINAN PUZZLE PADA ANAK KELOMPOK B DI TK TUNAS RIMBA 1 SAMARINDA TAHUN PEMBELAJARAN 2016/2017
Authors: Sudarwati Umi -
Published: March 2020

The background of this research is the importance of the ability to count for early childhood, to be able to hone the cognitive development of children, especially in the field of mathematics. So the need for learning methods that can meet the needs of children. The formulation of the problem in this research is how to improve the ability of spelled out 1-20 through the puzzle game in the children group B TK Tunas Rimba 1 Samarinda. The purpose of this study is to find out how the puzzle game can improve the ability to count 1-20 children. This type of research is a classroom action research. Research subjects were teachers and children group B TK Tunas Rimba 1 Samarinda. The classroom teacher acts as the executing subject of action and child group B TK Tunas Rimba 1 Samarinda as the subject of the recipient of the action of 15 people. The object of this research is Improved 1-20 through the ability of the game puzzle. Data collection techniques use observation techniques. The research instrument used is observation sheet and documentation in the form of portfolio observation sheet and checklist. Data analysis used in this research is descriptive qualitative with percentage. The result of data analysis is known that the ability of children to be 1-20 through puzzle game in cycle I is got average value 44 with criteria less once, then increase in cycle II by 43%, obtained by average value 63 with enough criteria. and on the third cycle increased by 19%, obtained an average value of 75 with good criteria. So we can get 1-20 children from cycle I to cycle III 70%. The conclusion of this research result that through puzzle game can improve the ability of counted 1-20 early childhood, especially child group B TK Tunas Rimba 1 Samarinda Year Learning 2016/2017.
PENINGKATAN MOTORIK HALUS ANAK MELALUI KEGIATAN MEROBEK KERTAS PADA ANAK USIA 4-5 TAHUN TK NEGERI 2 SAMARINDA
Authors: Adiningsih Vivi Endang , Syafrina Rizqi -
Published: March 2020

Children cannot use their fine motoric skill well in paper-tearing activity. It seems that there are still many children who do not participate in the paper tearing activity, as exemplified by the teacher. This is proven when children do paper tearing activities. The aim of this research is to improve children's fine motor skills through paper tearing on children aged 4-5 years. The method used in this study is classroom action research (CAR) and a descriptive research which carried out in two cycles consisting of 3 meetings in each cycle. Research procedures that were carried out in this study were planning, implementation, observation and reflection. The subjects of this study were 19 children aged 4-5 years, consisted of 7 boys and 12 girls. The results showed that the children's fine motor skills improved compared to the pre-cycle phase. In cycle I, there was an increase from pre-cycle with an average value of 31.3% to 60.9% through the first, second and third meeting and succeeded in the second cycle through the first, second and third meeting with an average value of 87.4% in which this value has reached the target of success indicator that is 85%. Based on the results of the study, it can be concluded that paper tearing activity can improve children aged 4-5 yearsâ€™ fine motoric skills and it is suggested to kindergarten teachers to make paper tearing activities as a media for improving children's fine motoric skills.
Hubungan Depresi dan Sindrom Dispepsia pada Pasien Penderita Keganasan Yang Menjalani Kemoterapi di RSUP DR. M. Djamil Padang
Authors: Rulianti1 Mona Rahmi , Almasdy Dedy , Murni Arina Widya
Published: March 2020

AbstrakGangguan psikologi dan sindrom dispepsia (seperti mual dan muntah) merupakan hal yang sering terjadi pada pasien kanker yang menjalani kemoterapi. Penelitian ini bertujuan untuk melihat hubungan depresi dengan sindrom dispepsia yang terjadi pada pasien keganasan yang menjalani kemoterapi. Metode penelitian ini menggunakan rancangan cross sectional dengan menggunakan kuisioner. Didapatkan pasien sebanyak 56 pasien keganasan yang menjalani kemoterapi di bangsal Penyakit Dalam, Bedah dan Obstetri & Ginekologi RSUP Dr. M. Djamil Padang selama 3 bulan (Desember 2012-Februari 2013). Depresi dinilai dengan wawancara menggunakan kuisioner BDI (Beck Depression Inventory) II. Dispepsia dinilai dengan menggunakan kuisioner pedoman skor dispepsia. Data dianalisis dengan SPSS 17 menggunakan analisis korelasi bivariat Spearman. Koefisien korelasi untuk depresi dan sindrom dispepsia adalah 0,387. Kesimpulan akhir dari penelitian ini adalah ada hubungan yang cukup dan searah (p<0,01) antara depresi dan sindrom dispepsia yang terjadi pada pasien keganasan yang menjalani kemoterapi.Kata kunci: kanker, kemoterapi, depresi, sindrom dispepsiaAbstractPsychological disorders and dyspepsia syndromes (such as nausea and vomiting) is a common thing in cancer patients undergoing chemotherapy. This study aims to examine the relationship of depression with dyspepsia syndrome that occurs in patients with malignancies who are undergoing chemotherapy. Methods this study uses cross-sectional design using questionnaires. Obtained for 56 patients who underwent chemotherapy malignancy patients in wards Internal Medicine, Surgery and Obstetrics & Gynecology in Hospital Dr. M. Djamil Padang for 3 months (December 2012-February 2013). Depression was assessed by interview using a questionnaire BDI (Beck Depression Inventory) II. Dyspepsia assessed using questionnaires guidelines dyspepsia score. Data were analyzed with SPSS 17 using bivariate Spearman correlation analysis. The correlation coefficients for depression and dyspepsia syndrome was 0.387. The final conclusion of this study is that there are sufficient and direct relationship (p <0.01) between depression and dyspepsia syndrome that occurs in patients with malignancies who are undergoing chemotherapy.Keywords: cancer, chemotherapy, depression, dyspepsia syndrome
Capillary Haemangioma of Nasal Septum
Authors: Budiman Bestari J , Octiza Ricki
Published: March 2020

AbstrakCapillary haemangioma is a benign, rapidly growing lesion of the skin and mucous membranes. It may rarely present as a mass of considerable size and thus entirely fill the nasal cavity. Its etiology remains obscure. Capillary haemangioma usually involves the gingiva, lips, tongue, and buccal mucosa. However, the nasal cavity is a rare location for this lesion. The most common symptoms are unilateral epistaxis and nasal obstruction. The treatment of choice is surgery to remove the tumour even for large lesion. A case of capillary haemangioma at anterior nasal septal in 6 years old girl had been treated with extirpation.Kata kunci: Capillary haemangioma, nasal septum, epistaxis, diagnosis, treatmentAbstractHaemangioma kapiler merupakan suatu lesi jinak pada kulit dan mukosa dengan pertumbuhan yang cepat. Meskipun jarang berukuran besar, namun dapat memenuhi seluruh kavum nasi. Etiologinya sampai sekarang masih belum jelas. Haemangioma kapiler sering terdapat pada ginggiva, bibir, lidah dan mukosa bukal. Kavum nasi merupakan lokasi yang jarang terdapatnya haemangioma kapiler. Gejala yang paling sering adalah unilateral epistaksis dan sumbatan hidung. Pembedahan untuk mengangkat tumor ini merupakan terapi pilihan meskipun berukuran besar. Suatu kasus haemangioma kapiler septum anterior pada anak perempuan berumur 6 tahun telah dilakukan ekstirpasi sebagai terapi.Keywords: Haemangioma kapiler, septum nasi, epistaksis, diagnosis, penatalaksanaan
Perbedaan Perlukaan Genitalia Perempuan Berdasarkan Posisi Persetubuhan Diluar Perkawinan di RSUP Dr. M. Djamil Padang Tahun 2010-2012
Authors: Nursasmi Ami Tri , Susanti Rika , Bachtiar Hafni
Published: March 2020

AbstrakPersetubuhan diluar perkawinan menjadi suatu masalah di pengadilan karena banyaknya perbedaan pendapat mengenai perlukaan selaput dara. Penelitian ini dilakukan untuk membuktikan perbedaan perlukaan selaput dara tersebut yang dilakukan di RSUP Dr. M. Djamil Padang, mencakup karakteristik korban, perlukaan selaput dara, perlukaan dibagian tubuh lain, dan hubungan perlukaan berdasarkan posisi persetubuhan. Penelitian ini bersifat analitik. Sampel sebanyak 81 responden yang telah mengalami persetubuhan diluar perkawinan. Data diambil dari Bagian Forensik RSUP Dr. M. Djamil Padang periode bulan Juli 2010 sampai dengan Juli 2012. Data diolah dengan menggunakan program komputer dan dianalisis melalui uji chi square. Dari 81 subjek penelitian ditemukan hasil tertinggi berupa usia korban adalah 12-18 tahun (62%), pekerjaan sebagai pelajar (56%), alamat berada di Kecamatan Koto Tangah (20%), hubungan korban dengan pelaku sebagai pacar (48%), perlukaan selaput dara pada arah jarum jam selain 5 dan 7 (47%), tidak tampaknya tanda-tanda kekerasan dibagian tubuh lain (81%). Dari uji chi square didapatkan nilai p = 0,585 dengan demikian Ha penelitian ditolak (p>0,05). Penelitian ini dapat disimpulkan bahwa tidak terdapatnya hubungan yang signifikan antara perlukaan selaput dara dengan posisi persetubuhan diluar perkawinan.Kata kunci: Persetubuhan, selaput dara, perlukaanAbstractNon marital sexual activity has been being a big issues on the court because there are contradictions argument about wounded hymen. This research is conducted to prove the difference of that wound occurs in public hospital of dr.M.Djamil Padang, including the victim’s character, hymen’s injury, another injury in other parts body, and the connection of each injuries based on intercourse position. This research having an analitical nature. 81 respondents of sample who done non marital sexual activity. The data taken from Forensics division of RSUP dr.M.Djamil Padang for period of July 2010 to July 2012. The data be treated with computer program and analyzed by chi square test. From 81 subjects of research found the highest result are the age of victim in range 12-18 years old (62%), the occupation as a student (56%), the address in Koto Tangah sub district (20%), the relation of victim and executants as a boyfriend (48%), wounded hymen injured in except area 5 and 7 (47%), no other visible injuries due to violation in other parts of the victim’s bodies (81%). From chi square test, the vale of p=0,585 as the result and the conclusion this research of Ha rejected (p>0,05)]. The conclusion of this research, there is no significant relationship between wounded hymen injured with non marital sexual activity.Keywords:sexual intercourse, hymen, injury
Hubungan Tingkat Pengetahuan Ibu dengan Pemberian Imunisasi Dasar Lengkap pada Bayi di Kelurahan Parupuk Tabing Wilayah Kerja Puskesmas Lubuk Buaya Kota Padang Tahun 2013
Authors: Dewi Atika Putri , Darwin Eryati , Edison Edison
Published: March 2020

AbstrakDi kota Padang cakupan imunisasi sebesar 88,1% dengan cakupan terendah di wilayah kerja Puskesmas Lubuk Buaya sebesar 81,8%. Serta Kelurahan Parupuk Tabing merupakan kelurahan yang cakupannya terendah dan angka drop-out tertinggi sebesar 12,9% di tahun 2012. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan ibu dengan pemberian imunisasi dasar lengkap bayi di wilayah kerja Kelurahan Parupuk Tabing Wilayah Kerja Puskesmas Lubuk Buaya Kota Padang Tahun 2013.Metode: Jenis penelitian ini analitik dengan desain cross-sectional. Populasi adalah ibu yang memiliki bayi usia 1-2 tahun di Kelurahan Parupuk Tabing. Jumlah sampel 63 orang diambil secara Random Sampling. Data dikumpulkan melalui wawancara menggunakan kuesioner dan observasi.pengolahan data dilakukan secara komputerisasi dengan analisis uji Chi-Square pada α=0,05. Didapatkan 57,1%, responden memberikan imunisasi dasar lengkap pada bayinya dan 63,5%. responden yang mempunyai pengetahuan yang cukup tentang imunisasi dasar lengkap. Didapatkan adanya hubungan bermakna antara kedua variabel tersebut.Kesimpulan: terdapat hubungan yang bermakna antara pengetahuan ibu terhadap pemberian imunisasi dasar lengkap pada bayi di kelurahan Parupuk Tabing wilayah kerja puskesmas Lubuk Buaya. Sehingga disarankan kepada kader posyandu dan petugas puskesmas agar memberikan penyuluhan tentang imunisasi, fungsi, dan jadwal pemberian imunisasi tersebut.Kata kunci: imunisasi dasar lengkap, pengetahuanAbstractIn the city of Padang immunization coverage was 88.1% with the lowest coverage in the Lubuk Buaya Public Health Centre was 81.8 % .Village of Parupuk Tabing was the lowest coverage and highest drop-out rate of 12.9% in 2012. This study aims to determine relationshipof the level of mother's knowledge with base complete infant immunization in the Village of Parupuk Tabing Lubuk Buaya Public Health Centre working area in the City of Padang in 2013. Type of this study is analytic study in the form of a cross - sectional design. The population of this study is all of mothers with babies aged 1-2 years in the Village of Parupuk Tabing. The number of samples taken 63 Random Sampling. Data were collected by interviews using questionnaires.Computerized data processing and analisis perfomed by Chi - Square test at α = 0.05. Obtained 57.1% of respondents are fully immunized and 63.5 % of the respondents have sufficient knowledge about the complete basic immunization. There was a significant correlation between the two variables (p=0,000). There was a significant relationship between mother's knowledge to complete basic immunization in infants in Village of Parupuk Tabing Lubuk Buaya Public Health Centre working area. So it is advisable to officer cadre of health posts and health centers that provide counseling about immunization, function, and the immunization schedule.Keywords:complete basic immunization, knowledge