bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary Arterial Hypertension and Drug-Induced Hypertension in Philadelphia-Negative Classical Myeloproliferative Neoplasms: A Systematic Review
Authors: Găman Mihnea-Alexandru , Kipkorir Vincent , Srichawla Bahadar S. , Dhali Arkadeep , Găman Amelia Maria , Diaconu Camelia Cristina
Published: January 2023

The impact of primary arterial hypertension (HTN) in myeloproliferative neoplasms (MPNs) remains unclear, with scant literature available, mostly focusing on cardiovascular risk factors as a singular entity or on organ-specific HTN. Furthermore, available studies reporting findings on drug-induced HTN in MPNs report varying and contradictory findings. In consideration of the above, this study set out to systematically review the available literature and shed light on the occurrence of HTN in MPNs, its association with thrombosis, as well as the drugs used in MPN management that could increase blood pressure. The literature search yielded 598 potentially relevant records of which 315 remained after the duplicates (n = 283) were removed. After we screened the titles and the abstracts of these publications, we removed irrelevant papers (n = 228) and evaluated the full texts of 87 papers. Furthermore, 13 records did not meet the inclusion criteria and were excluded from the systematic review. Finally, a total of 74 manuscripts were entered into the qualitative synthesis and included in the present systematic review. Our systematic review highlights that HTN is the most common comorbidity encountered in MPNs, with an impact on both the occurrence of thrombosis and survival. Moreover, drug-induced HTN remains a challenge in the management of MPNs. Further research should investigate the characteristics of patients with MPNs and HTN, as well as clarify the contribution of HTN to the development of thrombotic complications, survival and management in MPNs. In addition, the relationship between clonal hematopoiesis of indeterminate potential, HTN, cardiovascular disease and MPNs requires examination in upcoming assessments.
Biochemical, Histological, and Ultrastructural Studies of the Protective Role of Vitamin E on Cyclophosphamide-Induced Cardiotoxicity in Male Rats
Authors: Attia Azza A. , Sorour Jehan M. , Mohamed Neama A. , Mansour Tagreed T. , Al-Eisa Rasha A. , El-Shenawy Nahla S.
Published: January 2023

Background: Cyclophosphamide (CP) (Cytoxan or Endoxan) is an efficient anti-tumor agent, widely used for the treatment of various neoplastic diseases. The study aimed to investigate the protective role of vitamin E (vit E) in improving cardiotoxicity in rats induced by CP. Materials and methods: Forty male Wistar rats were divided randomly into four experimental groups (each consisting of ten rats); the control group was treated with saline. The other three groups were treated with vit E, CP, and the combination of vit E and CP. Serum lipid profiles, enzyme cardiac biomarkers, and cardiac tissue antioxidants were evaluated, as well as histological and ultrastructure investigations. Results: CP-treated rats showed a significant increase in serum levels of cardiac markers (troponin, CK, LDH, AST, and ALT), lipid profiles, a reduction in the antioxidant enzyme activities (CAT, SOD, and GPx), and an elevation in the level of lipid peroxidation (LPO). The increase in the levels of troponin, LDH, AST, ALP, and triglycerides is a predominant indicator of cardiac damage due to the toxic effect of CP. The biochemical changes parallel cardiac injuries such as myocardial infarction, myocarditis, and heart failure. Vitamin E played a pivotal role, as it attenuated most of these changes because of its ability to scavenge free radicals and reduce LPO. In addition, vit E was found to improve the histopathological alterations caused by CP where no evidence of damage was observed in the cardiac architecture, and the cardiac fibers had regained their normal structure with minimal hemorrhage. Conclusions: As a result of its antioxidant activity and its stabilizing impact on the cardiomyocyte membranes, vit E is recommended as a potential candidate in decreasing the damaging effects of CP.
Suppression of Age-Related Macular Degeneration-like Pathology by c-Jun N-Terminal Kinase Inhibitor IQ-1S
Authors: Zhdankina Anna A. , Tikhonov Dmitry I. , Logvinov Sergey V. , Plotnikov Mark B. , Khlebnikov Andrei I. , Kolosova Nataliya G.
Published: January 2023

Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. The development of AMD is associated with inflammation, oxidative stress, and progressive proteostasis imbalance, in the regulation of which c-Jun N-terminal kinases (JNK) play a crucial role. JNK inhibition is discussed as an alternative way for prevention and treatment of AMD and other neurodegenerative diseases. Here we assess the retinoprotective potential of the recently synthesized JNK inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S) using senescence-accelerated OXYS rats as a model of AMD. The treatment with IQ-1S (50 mg/kg body weight intragastric) during the period of active disease development (from 4.5 to 6 months of age) improved some (but not all) histological abnormalities associated with retinopathy. IQ-1S improved blood circulation, increased the functional activity of the retinal pigment epithelium, reduced the VEGF expression in the endothelial cells, and increased the expression of PEDF in the neuroretina. The result was a decrease in the degeneration of photoreceptors and neurons of the inner layers. IQ-1S significantly improved the retinal ultrastructure and increased the number of mitochondria, which were significantly reduced in the neuroretina of OXYS rats compared to Wistar rats. It seems probable that using IQ-1S can be a good prophylactic strategy to treat AMD.
Neuro-Urology: Call for Universal, Resource-Independent Guidance
Authors: Werneburg Glenn T. , Welk Blayne , Averbeck Marcio A. , Blok Bertil F. M. , Hamid Rizwan , Kennelly Michael J. , Liao Limin , Musco Stefania , Vasudeva Pawan , Kessler Thomas M.
Published: January 2023

Neurogenic lower urinary tract dysfunction (NLUTD), the abnormal function of the lower urinary tract in the context of neurological pathology, has been the subject of multiple efforts worldwide for the development of clinical practice guidelines. These guidelines are based on the same body of evidence, and are therefore subject to the same gaps. For example, sexual and bowel dysfunction in the context of NLUTD, optimal renal function assessment in those who are non-ambulatory or with low muscle mass, optimal upper tract surveillance timing, and modification of diagnostic and treatment modalities for low-resource nations and communities are inadequately addressed. In addition, many aspects of the conclusions and final recommendations of the guidelines are similar. This duplicative work represents a large expenditure of time and effort, which we believe could be focused instead on evidence gaps. Here, we call for a global unified approach to create a single, resource-independent, comprehensive guidance on NLUTD, neurogenic sexual, and neurogenic bowel dysfunction. Targeted research addressing the evidence gaps should be called for and pursued. This will allow for focus to shift to filling the gaps in the evidence for future guidelines.
Assessment of Brainstem Functional Organization in Healthy Adults and Overactive Bladder Patients Using Ultra-High Field fMRI
Authors: Fernández Chadily Susana , de Rijk Mathijs M. , Janssen Janine M. W. , van den Hurk Job , van Koeveringe Gommert A.
Published: January 2023

The pathophysiological mechanisms of overactive bladder syndrome (OAB) remain largely unknown, with major involvement of the central nervous system (CNS). The periaqueductal gray (PAG) is a brainstem area which is indicated to play an essential role in bidirectional communication between the bladder and the CNS. We aimed to assess consistency of PAG functional organization across different bladder sensory states in OAB patients. We propose, that PAG functional organization patterns across sensory states will differ between controls and OAB patients. We analyzed fMRI scans at 7 Tesla from six controls and two OAB patients. The Louvain module detection algorithm was applied to parcellate the PAG in empty and full bladder states. We assessed within-subject consistency and investigated differences in this consistency between both groups. High within-subject agreement of PAG parcellations between empty and full bladder states was demonstrated in both groups. Additionally, we showed that the correlations between PAG clusters in both bladder states were significantly different in patients compared to controls (p = 0.039). The methods introduced here offer a promising tool to assess functional organization of the PAG and understand the underlying pathology and the role of this region in OAB syndrome.
Subject Separation Network for Reducing Calibration Time of MI-Based BCI
Authors: Hu Haochen , Yue Kang , Guo Mei , Lu Kai , Liu Yue
Published: January 2023

Motor imagery brain–computer interface (MI-based BCIs) have demonstrated great potential in various applications. However, to well generalize classifiers to new subjects, a time-consuming calibration process is necessary due to high inter-subject variabilities of EEG signals. This process is costly and tedious, hindering the further expansion of MI-based BCIs outside of the laboratory. To reduce the calibration time of MI-based BCIs, we propose a novel domain adaptation framework that adapts multiple source subjects’ labeled data to the unseen trials of target subjects. Firstly, we train one Subject Separation Network(SSN) for each of the source subjects in the dataset. Based on adversarial domain adaptation, a shared encoder is constructed to learn similar representations for both domains. Secondly, to model the factors that cause subject variabilities and eliminate the correlated noise existing in common feature space, private feature spaces orthogonal to the shared counterpart are learned for each subject. We use a shared decoder to validate that the model is actually learning from task-relevant neurophysiological information. At last, an ensemble classifier is built by the integration of the SSNs using the information extracted from each subject’s task-relevant characteristics. To quantify the efficacy of the framework, we analyze the accuracy–calibration cost trade-off in MI-based BCIs, and theoretically guarantee a generalization bound on the target error. Visualizations of the transformed features illustrate the effectiveness of domain adaptation. The experimental results on the BCI Competition IV-IIa dataset prove the effectiveness of the proposed framework compared with multiple classification methods. We infer from our results that users could learn to control MI-based BCIs without a heavy calibration process. Our study further shows how to design and train Neural Networks to decode task-related information from different subjects and highlights the potential of deep learning methods for inter-subject EEG decoding.
Fatigue Behavior of M20 Torque Shear High-Strength Bolts under Constant-Amplitude Loading
Authors: Zhang Liang , Lei Honggang , Shen Yu , Zhang Shujia , Zhou Zichun
Published: January 2023

Torque-shear high strength bolts were developed and widely used recently, and such high-tensile bolts may fracture in practical engineering due to the frequent complex loads, resulting in economic losses and even casualties. However, the fatigue performance of M20 torque shear high-strength bolts under constant-amplitude loading has not been investigated yet, and there are no specific design provisions for determining the constant-amplitude fatigue performance of such bolts. Hence, a total of 10 constant-amplitude fatigue tests were conducted using an MTS fatigue testing machine. For comparison, five different stress amplitudes were investigated. The fatigue performance, stress concentration and fracture analysis were analyzed. The scanning electron microscope images of fatigue failure were obtained to analyze the fatigue fracture characteristics of high-tensile bolts. A finite element model was established to analyze the stress distribution and the hot-spot stress of the bolts. The results suggested that the allowable nominal stress amplitude of M20 torque-shear type high-strength bolts was 96.371 MPa, while the allowable hot-spot stress amplitude was 283.296 MPa. Finally, the test results were compared against the existing design provisions. Upon comparison, the existing design formulas in GB 50017(2017), ANSI/AISC 360-16 (2010) and Eurocode 3 (2003) were found to be generally conservative. The S-N curve of torque-shear high strength bolts under constant-amplitude loading was proposed using the hot-spot stress amplitudes.
Carbon Capture Materials in Post-Combustion: Adsorption and Absorption-Based Processes
Authors: Allangawi Abdulrahman , Alzaimoor Eman F. H. , Shanaah Haneen H. , Mohammed Hawraa A. , Saqer Husain , El-Fattah Ahmed Abd , Kamel Ayman H.
Published: January 2023

Global warming and climate changes are among the biggest modern-day environmental problems, the main factor causing these problems is the greenhouse gas effect. The increased concentration of carbon dioxide in the atmosphere resulted in capturing increased amounts of reflected sunlight, causing serious acute and chronic environmental problems. The concentration of carbon dioxide in the atmosphere reached 421 ppm in 2022 as compared to 280 in the 1800s, this increase is attributed to the increased carbon dioxide emissions from the industrial revolution. The release of carbon dioxide into the atmosphere can be minimized by practicing carbon capture utilization and storage methods. Carbon capture utilization and storage (CCUS) has four major methods, namely, pre-combustion, post-combustion, oxyfuel combustion, and direct air capture. It has been reported that applying CCUS can capture up to 95% of the produced carbon dioxide in running power plants. However, a reported cost penalty and efficiency decrease hinder the wide applicability of CCUS. Advancements in the CCSU were made in increasing the efficiency and decreasing the cost of the sorbents. In this review, we highlight the recent developments in utilizing both physical and chemical sorbents to capture carbon. This includes amine-based sorbents, blended absorbents, ionic liquids, metal-organic framework (MOF) adsorbents, zeolites, mesoporous silica materials, alkali-metal adsorbents, carbonaceous materials, and metal oxide/metal oxide-based materials. In addition, a comparison between recently proposed kinetic and thermodynamic models was also introduced. It was concluded from the published studies that amine-based sorbents are considered assuperior carbon-capturing materials, which is attributed to their high stability, multifunctionality, rapid capture, and ability to achieve large sorption capacities. However, more work must be done to reduce their cost as it can be regarded as their main drawback.
Bismuth-Based Multi-Component Heterostructured Nanocatalysts for Hydrogen Generation
Authors: Shaheen Saman , Sadiq Iqra , Ali Syed Asim , Ahmad Tokeer
Published: January 2023

Developing a unique catalytic system with enhanced activity is the topmost priority in the science of H2 energy to reduce costs in large-scale applications, such as automobiles and domestic sectors. Researchers are striving to design an effective catalytic system capable of significantly accelerating H2 production efficiency through green pathways, such as photochemical, electrochemical, and photoelectrochemical routes. Bi-based nanocatalysts are relatively cost-effective and environmentally benign materials which possess advanced optoelectronic properties. However, these nanocatalysts suffer back recombination reactions during photochemical and photoelectrochemical operations which impede their catalytic efficiency. However, heterojunction formation allows the separation of electron–hole pairs to avoid recombination via interfacial charge transfer. Thus, synergetic effects between the Bi-based heterostructured nanocatalysts largely improves the course of H2 generation. Here, we propose the systematic review of Bi-based heterostructured nanocatalysts, highlighting an in-depth discussion of various exceptional heterostructures, such as TiO2/BiWO6, BiWO6/Bi2S3, Bi2WO6/BiVO4, Bi2O3/Bi2WO6, ZnIn2S4/BiVO4, Bi2O3/Bi2MoO6, etc. The reviewed heterostructures exhibit excellent H2 evolution efficiency, ascribed to their higher stability, more exposed active sites, controlled morphology, and remarkable band-gap tunability. We adopted a slightly different approach for reviewing Bi-based heterostructures, compiling them according to their applicability in H2 energy and discussing challenges, prospects, and guidance to develop better and more efficient nanocatalytic systems.
Validation of the Concise Assessment Scale for Children’s Handwriting (BHK) in an Italian Population
Authors: Loizzo Annalivia , Zaccaria Valerio , Caravale Barbara , Di Brina Carlo
Published: January 2023

Handwriting difficulties represent a common complaint among children and may cause a significant delay in motor skills achievement. The Concise Assessment Scale for Children’s Handwriting (BHK) assesses handwriting skill in clinical and experimental settings, providing a quick evaluation of handwriting quality and speed through a copying text. The aim of the present study was to validate the Italian adaptation of the BHK in a representative primary school population. Overall, 562 children aged 7–11 from 16 public primary schools of Rome were included and asked to copy a text in 5 min using cursive handwriting. Handwriting quality and copying speed were measured. The included population followed a normal distribution for the BHK quality scores. Sex influenced the total quality scores, whereas school level influenced the copying speed. The BHK quality score was higher in girls (p < 0.05) and resulted as a stable parameter along the school years, without significant variations with regard to the years spent in handwriting exercise (p = 0.76). The handwriting speed was influenced by school level, and significant differences were found for each of the grades from the second to the fifth (p < 0.05), but not for gender (p = 0.47). Both BHK measures represent a helpful tool for the characterization and assessment of children with handwriting difficulties. The present study confirms that sex influences total BHK quality score, while school level influences handwriting speed.
Morphologic Mandibular Bone Changes on Panoramic Radiographs of Children and Adolescents with Congenital Heart Disease
Authors: Saraç Fatma , Şengül Fatih , Çelikel Periş , Saraç İbrahim , Baş Aybike , Derelioğlu Sera Şimşek
Published: January 2023

Congenital heart disease (CHD) has effects on growth and development. However, information on how the structure of the mandibular bone is affected is limited. In the present study, we aim to compare mandibular bone structures of children affected with CHD and healthy ones through the fractal analysis method and radiomorphometric indices based on panoramic radiographs. The study consisted of 80 children (20 with cyanotic CHD, 20 with acyanotic CHD, 40 control) who were diagnosed with CHD and were treated through interventional therapy or followed up through medical therapy. Fractal dimension (FD) was performed in three different areas (angulus, corpus, and interdental bone) on 80 panoramic radiographs. Additionally, we assessed various radiomorphometric indices: mandibular cortical width (MCW), panoramic mandibular index (PMI), mandibular cortical index (MCI), and simple visual estimation (SVE). p < 0.05 was accepted as statistically significant in the analysis. Values of mean MCW, PMI, MCI, SVE, and FD measurements in children affected with CHD were found to be similar to the control group, regardless of whether they were cyanotic or acyanotic (p > 0.05). In this study, fractal analysis and radiomorphometric indices revealed no trabecular structure and mineral density changes in mandibular bone of children and adolescents with CHD compared to healthy subjects.
Mediterranean Milk Ladder: Integrating a Healthy Eating Plan While Reintroducing Cow’s Milk
Authors: Vassilopoulou Emilia , McMilin Colleen , Venter Carina
Published: January 2023

The process of gradually reintroducing food allergens into an individual’s diet is referred to as a food allergen “ladder”, and the most recent edition of the original Milk Allergy in Primary (MAP) Care Guidelines, as well as the International Milk Allergy in Primary Care (IMAP), includes a shortened, improved, and international version with specific recipes, indicating the exact milk protein content, as well as the duration of heating and the temperature for each step of the ladder. Food allergen ladders are being used increasingly in clinical practice. The aim of this study was to develop a Mediterranean milk ladder based on the principles of the Mediterranean eating pattern. The protein content delivered in a portion of the final food product in each step of the ladder in the Mediterranean version corresponds to that provided in the IMAP ladder. Different recipes for the various steps were provided to increase acceptability and variety. Quantification of the total milk protein, casein content, and beta-lactoglobulin by Enzyme-linked immunosorbent assay (ELISA) could detect the gradual increase in concentrations, but the accuracy of the method was affected by the presence of the other ingredients in the mixtures. When developing the Mediterranean milk ladder, a key consideration was to reduce the amount of sugar by using limited amounts of brown sugar and substituting sugar with fresh fruit juice or honey for children aged older than one year. The proposed Mediterranean milk ladder includes principles of (a) healthy eating based on the Mediterranean diet and (b) the acceptability of foods across different age groups.
Sudden Appearance of a Palpable Chest Wall Mass Secondary to Macrocystic Lymphatic Malformation: A Case Report
Authors: Alkwai Hend , Alkwai Hala , Al Namshan Mohammed
Published: January 2023

Chest wall lymphatic malformations are rare and can pose a diagnostic dilemma, particularly if they present abruptly. This case report describes a 15-month-old male toddler presenting with a left lateral chest mass. Histopathology of the surgically excised mass confirmed the diagnosis of a macrocystic lymphatic malformation. Furthermore, there was no recurrence of the lesion in the two-year follow-up period.
Effects of Rapid Palatal Expansion on the Upper Airway Space in Children with Obstructive Sleep Apnea (OSA): A Case-Control Study
Authors: Galeotti Angela , Gatto Roberto , Caruso Silvia , Piga Simone , Maldonato Wanda , Sitzia Emanuela , Viarani Valeria , Bompiani Gaia , Aristei Francesco , Marzo Giuseppe , Festa Paola
Published: January 2023

Obstructive Sleep Apnea (OSA) in children needs a multidisciplinary approach. Even if the first-line treatment of pediatric OSA is adenotonsillectomy, nowadays rapid palatal expansion (RPE) is considered a valid additional treatment. The aim of this study is to evaluate cephalometric changes in upper airways dimensions after rapid palatal expansion (RPE) in children suffering from Obstructive Sleep Apnea (OSA). A total of 37 children (range age 4–10 years) with diagnosis of OSA referred to Dentistry Unit of Bambino Gesù Children’s Research Hospital IRCCS (Rome, Italy) were included in this pre-post study and underwent lateral radiographs at the start (T0) and at the end (T1) of a RPE treatment. Inclusion criteria were: diagnosis of OSA confirmed by cardiorespiratory polygraphy (AHI > 1) or pulse oximetry (McGill = >2), skeletal maxillary contraction evaluated by presence of posterior crossbite. A control group of 39 untreated patients (range age 4–11 years), in good general health, was set up. A paired T-test was used to investigate the statistical differences between T0 and T1 values in both groups. The results showed a statistically significant increase of nasopharyngeal width in the treated group after RPE treatment. Moreover, the angle that identifies mandibular divergence compared to palatal plane (PP-MP°) was significantly reduced. In the control group, no statistically significant differences were observed. The present study showed that RPE treatment determines a significant sagittal space increase in the upper airways space and a counterclockwise mandibular growth in children with OSA compared to a control group. These results suggest that a widening of the nasal cavities induced by RPE may support a return to physiological nasal breathing and promote a counterclockwise mandibular growth in children. This evidence confirms the crucial role of the orthodontist in the management of OSA in pediatric patients.
Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
Authors: Geronikolou Styliani A. , Vasdekis Vasilis , Mantzou Aimilia , Davos Constantinos , Cokkinos Dennis V. , Chrousos George P.
Published: January 2023

This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11–14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1–4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli.
Surveying Parents of Preschool Children about Digital and Analogue Play and Parent–Child Interaction
Authors: Istenič Andreja , Rosanda Violeta , Gačnik Mateja
Published: January 2023

The addition of digital toys to the child’s toy box has resulted in the development of the new ‘digital play’, which differs from analogue play. Research shows that digital toys are available from infancy onwards and are significantly changing the way children engage in play and communicate with parents during play. How this influences the child’s development must be established. The choice of toys and the manner in which they are used depend greatly on the parents. In the present study, parents’ opinions and experiences of their child’s digital and analogue play were explored in order to gain insight into the parents’ perceptions of the impact of different types of play on their child’s development. We were particularly interested in the differences in a child’s engagement with a toy and the child–parent interaction and communication. In this descriptive study, we administered a questionnaire in order to collect data from 306 parents of children of an average age of 3.6 years. The results show that parents perceived traditional toys as the most stimulating toys for a toddler’s sensory, motor, cognitive, and socio-emotional development. During analogue play, significantly more parent–child interaction, as well as more language input from parents and toddlers, occurred. Parents also used different intervention and mediation strategies with different types of toys.
Nutritional Status and Circulating Levels of Fat-Soluble Vitamins in Cystic Fibrosis Patients: A Cohort Study and Evaluation of the Effect of CFTR Modulators
Authors: Francalanci Michela , Terlizzi Vito , Fevola Cristina , Di Rosa Giulia , Pierattini Valentina , Roselli Elena , Bonomi Paolo , Cavicchi Maria Chiara , Galici Valeria , Neri Anna Silvia , Bianchimani Chiara , Campana Silvia , Dolce Daniela , Ravenni Novella , Camera Erica , Orioli Tommaso , Taccetti Giovanni
Published: January 2023

Background: Improved therapy in CF has led to an overall improvement in nutritional status. The objectives of our study are: to cross-sectionally assess nutritional status and serum levels of fat-soluble vitamins; to retrospectively evaluate the efficacy of modulators on nutritional status and fat-soluble vitamin levels. Methods: In patients younger than 2 years of age, we evaluated growth, in patients aged 2–18 years, we assessed BMI z-scores, and in adults, we assessed absolute BMI values. Levels of 25(OH)D, vitamins A, and E were measured. Results: A cross-sectional analysis was conducted on 318 patients, 109 (34.3%) with pancreatic sufficiency. Only three patients were under 2 years old. In 135 patients aged 2–18 years, the median BMI z-score was 0.11, and 5 (3.7%) patients had malnutrition (z-score ≤ 2SD). In 180 adults, the median BMI was 21.8 kg/m2. Overall, 15 (13.7%) males (M) and 18 (25.3%) females (F) were underweight (18 < BMI > 20); 3 (2.7%) M and 5 (7.0%) F had a BMI < 18. Suboptimal 25(OH)D levels were found in patients with pancreatic insufficiency. The prevalence of deficiency of vitamins A and E is low. After one year of treatment with modulators, the increase in BMI was more consistent (M: 1.58 ± 1.25 kg/m2 F: 1.77 ± 1.21 kg/m2) in elexacaftor/tezacaftor/ivacaftor (ETI)-treated patients compared with other modulators, with a significant increase in levels of all fat-soluble vitamins. Conclusions: Malnutrition is present in a limited number of subjects. The prevalence of subjects with suboptimal 25(OH)D levels is high. ETI showed a beneficial effect on nutritional status and circulating levels of fat-soluble vitamins.
Cognitive Impairment and Dementia Data Model: Quality Evaluation and Improvements
Authors: Petrova-Antonova Dessislava , Lazarova Sophia
Published: January 2023

Recently, datasets with various factors and indicators of cognitive diseases have been available for clinical research. Although the transformation of information to a particular data model is straightforward, many challenges arise if data from different repositories have to be integrated. Since each data source keeps entities with different names and relationships at different levels of granularity and format, the information can be partially lost or not properly presented. It is therefore important to have a common data model that provides a unified description of different factors and indicators related to cognitive diseases. Thus, in our previous work, we proposed a hierarchical cognitive impairment and dementia data model that keeps the semantics of the data in a human-readable format and accelerates the interoperability of clinical datasets. It defines data entities, their attributes and relationships related to diagnosis and treatment. This paper extends our previous work by evaluating and improving the data model by adapting the methodology proposed by D. Moody and G. Shanks. The completeness, simplicity, correctness and integrity of the data model are assessed and based on the results a new, improved version of the model is generated. The understandability of the improved model is evaluated using an online questionnaire. Simplicity and integrity are also considered as well as the factors that may influence the flexibility of the data model.
Q-Balls in the Pseudogap Phase of Superconducting HgBa2CuO4+y
Authors: Campi Gaetano , Barba Luisa , Zhigadlo Nikolai D. , Ivanov Andrey A. , Menushenkov Alexey P. , Bianconi Antonio
Published: January 2023

Fast and local probes, such as X-ray spectroscopy, X-ray diffraction (XRD), and X-ray microscopy, have provided direct evidence for nanoscale phase separation in high temperature perovskite superconductors composed of (i) free particles coexisting with (ii) Jahn Teller polarons (i.e., charges associated with local lattice distortions) not detected by slow experimental methods probing only delocalized states. Moreover, these experimental probes have shown the formation of a superstripes phase in the pseudogap regime below T* in cuprates. Here, we focus on the anomalous temperature dependence of short range X-ray diffraction CDW reflection satellites with high momentum transfer, probing both charge and lattice fluctuations in superconducting HgBa2CuO4+y (Hg1201) in the pseudogap regime below T* and above Tc. We report compelling evidence of the anomalous anticorrelation of the coherence volume with the peak maximum amplitude of the CDW XRD satellite by cooling below T*. This anomalous temperature trend of the short-range striped Jahn Teller polaronic CDW puddles is in agreement with predictions of the Q-ball theory of the quark gluon plasma extended to cuprates, providing compelling evidence for non topological soliton puddles of striped condensate of pairs in the pseudogap phase.
The Structural Characteristics and Chemical Composition of Serpentine Jade Weathering Rinds: Implications for the Formation Process
Authors: Xue Shanna , He Mingyue , Yang Mei , Wu Shaokun
Published: January 2023

Weathering rind retains the greatest extent of the mineralogical and chemical composition information of the original mineral. Recently, we found some brownish-yellow or khaki serpentine jade weathering rinds with a thickness of 0.2–0.6 cm in Ji’an. The purpose of this paper is to explore differences in structural characteristics and chemical composition between weathering rinds and unweathered cores and summarize the formation of weathering rinds. In terms of structural characteristics, weathering rinds have smaller a0, b0, β values than unweathered cores; the specific surface area is 13.3987 m2/g; the pore volume is 0.0314 cm3/g; and the pore size distribution is characterized as more mesoporous (2–10 nm). The weathering rind shows partial dissolution of serpentine grains, increased porosity, and loosening structure. In terms of chemical composition, the weathering rind is characterized by the decrease of some serpentine major elements (Si, Mg, and Fe) and the increase of some impurity elements (Al, Ca, K, Na, and Cl). The weathering rind is the result of further alteration of serpentine jade, accompanied by the reduction of the Fe3+/Fe2+ ratio and the generation of the clay mineral (chlorite). In addition, it was also found that Ji’an serpentine jade belongs to Mg-bearing carbonate rock genesis, which are derived from marine deposits.
Design and Implementation of Reinforcement Learning for Automated Driving Compared to Classical MPC Control
Authors: Reda Ahmad , Vásárhelyi József
Published: January 2023

Many classic control approaches have already proved their merits in the automotive industry. Model predictive control (MPC) is one of the most commonly used methods. However, its efficiency drops off with increase in complexity of the driving environment. Recently, machine learning methods have been considered an efficient alternative to classical control approaches. Even with successful implementation of reinforcement learning in real-world applications, it is still not commonly used compared to supervised and unsupervised learning. In this paper, a reinforcement learning (RL)-based framework is suggested for application in autonomous driving systems to maintain a safe distance. Additionally, an MPC-based control model is designed for the same task. The behavior of the two controllers is compared and discussed. The trained RL model was deployed on a low-end FPGA-in-the-loop (field-programmable gate array in-the-loop). The results showed that the two controllers responded efficiently to changes in the environment. Specifically, the response of the RL controller was faster, at approximately 1.75 s, than that of the MPC controller, while the MPC provided better overshooting performance (approximately 1.3 m/s less) in terms of following the reference speeds. The reinforcement-learning model showed efficient behavior after being deployed on the FPGA with (4.9×10−6) m2/s as a maximum deviation compared to MATLAB Simulink.
A Comprehensive Review of Scab Disease Detection on Rosaceae Family Fruits via UAV Imagery
Authors: Ali Zain Anwar , Yang Chenguang , Israr Amber , Zhu Quanmin
Published: January 2023

Disease detection in plants is essential for food security and economic stability. Unmanned aerial vehicle (UAV) imagery and artificial intelligence (AI) are valuable tools for it. The purpose of this review is to gather several methods used by our peers recently, hoping to provide some knowledge and assistance for researchers and farmers so that they can employ these technologies more advantageously. The studies reviewed in this paper focused on Scab detection in Rosaceae family fruits. Feature extraction, segmentation, and classification methods for processing the UAV-obtained images and detecting the diseases are discussed briefly. The advantages and limitations of diverse kinds of UAVs and imaging sensors are also explained. The widely applied methods for image analysis are machine learning (ML)-based models, and the extensively used UAV platforms are rotary-wing UAVs. Recent technologies that cope with challenges related to disease detection using UAV imagery are also detailed in this paper. Some challenging issues such as higher costs, limited batteries and flying time, huge and complex data, low resolution, and noisy images, etc., still require future consideration. The prime significance of this paper is to promote automation and user-friendly technologies in Scab detection.
Emergent Criticality in Coupled Boolean Networks
Authors: Kang Chris , McElroy Madelynn , Voulgarakis Nikolaos K.
Published: January 2023

Early embryonic development involves forming all specialized cells from a fluid-like mass of identical stem cells. The differentiation process consists of a series of symmetry-breaking events, starting from a high-symmetry state (stem cells) to a low-symmetry state (specialized cells). This scenario closely resembles phase transitions in statistical mechanics. To theoretically study this hypothesis, we model embryonic stem cell (ESC) populations through a coupled Boolean network (BN) model. The interaction is applied using a multilayer Ising model that considers paracrine and autocrine signaling, along with external interventions. It is demonstrated that cell-to-cell variability can be interpreted as a mixture of steady-state probability distributions. Simulations have revealed that such models can undergo a series of first- and second-order phase transitions as a function of the system parameters that describe gene expression noise and interaction strengths. These phase transitions result in spontaneous symmetry-breaking events that generate new types of cells characterized by various steady-state distributions. Coupled BNs have also been shown to self-organize in states that allow spontaneous cell differentiation.
Advances in Electric Traction System—Special Issue
Authors: Szeląg Adam , Nikšić Mladen
Published: January 2023

Transportation does not produce goods by itself but is a service of moving people or goods that allows societies to thrive and develop [...]
Assessment of Recovered Struvite as a Safe and Sustainable Phosphorous Fertilizer
Authors: Mancho Carolina , Diez-Pascual Sergio , Alonso Juan , Gil-Díaz Mar , Lobo M. Carmen
Published: January 2023

Phosphorus (P) is an essential nutrient for crops. Modern agriculture is dependent on P derived from phosphate rock, which is a non-renewable resource that is becoming increasingly scarce and expensive. Therefore, it is necessary to identify alternative sources of P and develop novel technologies for its recovery. Such technologies are increasingly focused on the recovery of struvite (MgNH4PO4·6H2O) (STR) from urban wastewater. A reduction of P in effluents decreases the risk of eutrophication while allowing this mineral to be recovered and reused. Here we applied STR recovered from urban wastewater to three different soils and examined its slow-release properties. We performed a soil column leaching study and compared the results of soil treated with STR with those of soil amended with conventional phosphorous fertilizers, namely NPK, ammonium phosphate (MAP), and superphosphate (SSP). Phosphate leaching capacity followed the order MAP ~ NPK > SSP > STR in the three soils and was consistent with its rate of water solubility. Analysis of the soils after the leaching process showed differences in available P, the highest content being found in soils treated with STR. The results were consistent with those obtained in the leaching assay. STR behaves as a slow-release fertilizer and reduces the risk of eutrophication compared to the conventional P fertilizers tested.
Influence of Local Factors on Coastal Erosion: The Case of Vagueira Beach in Portugal
Authors: Magalhães Filho Luiz , Roebeling Peter , Coelho Carlos
Published: January 2023

Vagueira Beach, on the central Portuguese coast, is known as one of the places in Europe most affected by coastal erosion. The area has suffered more than 156 m of coastline retreat from the period 1958 to 2001. With the aim of evaluating the influence of local factors on coastal erosion, this paper assesses the anthropogenic and natural factors that are related to the retreat of the coastline by adopting statistical correlation and regression analyses. Through Pearson’s correlation coefficient (r), it was observed that local factors, such as annual dredging at the Aveiro Port entrance (r = 0.93), the total length of groins in the Espinho–Vagueira section (r = 0.89), and storm events (r = 0.52), are directly related to coastline retreat in the area. A multiple linear regression model was developed in which coastline retreat is explained by these same factors over the period 1980–2006. With a coefficient determination of R2 = 0.91, it was observed that the length of groins (significant at the 1% level), the dredging of the port entrance (significant at the 5% level), and precipitation (as a proxy for storm events; significant at the 10% level) are significantly correlated with coastline retreat. Hence, it is shown that anthropogenic factors are the main drivers of coastline retreat in Vagueira Beach. This study provides an innovative approach for the assessment of coastal erosion, resulting in important information that could be used for decision-making related to coastal zone management as it allows us to understand in greater detail the main drivers of coastal erosion.
Exploration of Ferrate(VI) Potential in Treating Lake Constance Water
Authors: Jiang Jia-Qian , Zhang Shaoqing , Petri Michael , Mosbach Christian
Published: January 2023

Occurrence of micropollutants in water and their potential impact on the environment and human health are arising concerns. The micropollutants are not removed efficiently by current wastewater treatment and a small amount of them get released into receiving waters accompanying the discharging of the treated wastewater effluents. Therefore, it is useful to investigate an advanced or alternative technology to remove traces of micropollutants in Lake Constance water during drinking water treatment. Among various oxidation processes, ferrate(VI) has received extensive attentions due to its superior dual properties of oxidation and coagulation. The work in this communication is the first trial using ferrate(VI) in comparison with FeCl3/ozonation to treat lake water and to remove micropollutants in the region. The results of pilot-scale trials showed that 10% of metformin, benzotriazole and acesulfam can be removed by ferrate(VI) at a dose of 0.1 mg L−1 from raw water, but FeCl3 with or without pre-ozonation cannot achieve the same performance. The degradability of three additional micropollutants by ferrate(VI) oxidation followed the sequences of bisphenol-S (BS) > azithromycin (AZM) > imidacloprid (IMP) was evaluated, and 100% concentration reduction of BS was achieved. The work suggests that ferrate(VI) is a potential alternative to the existing treatment processes for drinking water treatment.
Apoptotic Induction in Human Cancer Cell Lines by Antimicrobial Compounds from Antarctic Streptomyces fildesensis (INACH3013)
Authors: Astudillo-Barraza David , Oses Romulo , Henríquez-Castillo Carlos , Vui Ling Wong Clemente Michael , Pérez-Donoso José M. , Purcarea Cristina , Fukumasu Heidge , Fierro-Vásquez Natalia , Pérez Pablo A. , Lavin Paris
Published: January 2023

The Antarctic Streptomyces fildesensis has been recognized for its production of antimicrobial compounds with interesting biological activities against foodborne bacteria and multi-resistant strains, but not for its potential antiproliferative activity and mechanisms involved. Two bioactive ethyl acetate extract (EAE) fractions were purified via thin-layer chromatography and High-Performance Liquid Chromatography (HPLC), showing that orange-colored compounds displayed antimicrobial activity against pathogenic bacteria even after shock thermal treatment. The UV–VIS features of the active compounds, the TLC assay with actinomycin-D pure standard, Fourier transform infrared (FTIR) spectra and the ANTISMASH analysis support the presence of actinomycin-like compounds. We demonstrated that S. fildesensis displays antiproliferative activity against human tumor cell lines, including human breast cancer (MCF-7), prostate cancer (PC-3), colon cancer (HT-29) and non-tumoral colon epithelial cells (CoN). The half-maximal effective concentrations (EC50) ranged from 3.98 µg/mL to 0.1 µg/mL. Our results reveal that actinomycin-like compounds of S. fildesensis induced apoptosis mediated by caspase activation, decreasing the mitochondrial membrane potential and altering the cell morphology in all tumoral and non-tumoral cell lines analyzed. These findings confirm the potential of the psychrotolerant Antarctic S. fildesensis species as a promising source for obtaining potential novel anticancer compounds.
Anaerobic Co-Digestion of Agricultural Residues Produced in Southern and Northern Greece
Authors: Aravani Vasiliki P. , Tsigkou Konstantina , Papadakis Vagelis G. , Wang Wen , Kornaros Michael
Published: January 2023

In Greece biomass is often being disposed of uncontrollably, resulting in significant environmental impacts. The aim of this study is the single-stage anaerobic co-digestion assessment, valorizing Northern and Southern Greece mixtures, resulting from previous literature reviews, experimental designs, and biochemical methane potential (BMP) assays. Regarding the methane yield maximization, in Northern Greece, the most suitable mixture was 10% corn silage, 80% cattle manure, and 10% malt; while in Southern Greece it was 10% corn silage, 57% cattle manure, 23% orange peels, and 10% olive pomace for fall/winter season. The hydraulic retention time (HRT) was set at 20 d and an initial organic loading rate (OLR) of 2 g COD/(L·d) was applied, with a view to gradually increase it. However, volatile fatty acids accumulation was observed, which led to OLR reduction to 1.5 g COD/(L·d) for both experiments. The Northern Greece reactor operated successfully for OLR 1.5–5 g COD/(L·d), while further increase led to system failure. On the other hand, the reactor of the Southern Greece mixture operated successfully at OLR 1.5–2 g COD/(L·d), but further operation indicated inadequacy, probably due to inhibitor (such as limonene) accumulation. Mixtures consisting of corn silage, cattle manure, and malt can be successfully valorized at high OLR. However, further investigation for mixtures with orange peels is suggested due to the presence of inhibitors.