bluuebunny/crossref_metadata_2025 huggingface dataset:
A Stochastically Correlated Bivariate Square-Root Model
Authors: da Silva Allan Jonathan , Baczynski Jack , Vicente José Valentim Machado
Published: March 2024

We introduce a novel stochastically correlated two-factor (i.e., bivariate) diffusion process under the square-root format, for which we analytically obtain the corresponding solutions for the conditional moment-generating functions and conditional characteristic functions. Such solutions recover verbatim those of the uncorrelated case which encompasses a range of processes similar to those produced by a bivariate square-root process in which entries are correlated in the standard way, that is, via a constant correlation coefficient. Note that closed-form solutions for the conditional characteristic and moment-generating functions are not available for the latter. We focus on the financial scenario of obtaining closed-form expressions for the exact price of a zero-coupon bond and Asian option prices using a Fourier cosine series method.
Genome-Wide Association Study to Identify Marker–Trait Associations for Seed Color in Colored Wheat (Triticum aestivum L.)
Authors: Hong Min Jeong , Ko Chan Seop , Kim Dae Yeon
Published: March 2024

This study conducted phenotypic evaluations on a wheat F3 population derived from 155 F2 plants. Traits related to seed color, including chlorophyll a, chlorophyll b, carotenoid, anthocyanin, L*, a*, and b*, were assessed, revealing highly significant correlations among various traits. Genotyping using 81,587 SNP markers resulted in 3969 high-quality markers, revealing a genome-wide distribution with varying densities across chromosomes. A genome-wide association study using fixed and random model circulating probability unification (FarmCPU) and Bayesian-information and linkage-disequilibrium iteratively nested keyway (BLINK) identified 11 significant marker–trait associations (MTAs) associated with L*, a*, and b*, and chromosomal distribution patterns revealed predominant locations on chromosomes 2A, 2B, and 4B. A comprehensive annotation uncovered 69 genes within the genomic vicinity of each MTA, providing potential functional insights. Gene expression analysis during seed development identified greater than 2-fold increases or decreases in expression in colored wheat for 16 of 69 genes. Among these, eight genes, including transcription factors and genes related to flavonoid and ubiquitination pathways, exhibited distinct expression patterns during seed development, providing further approaches for exploring seed coloration. This comprehensive exploration expands our understanding of the genetic basis of seed color and paves the way for informed discussions on the molecular intricacies contributing to this phenotypic trait.
Co-Culture of P. gingivalis and F. nucleatum Synergistically Elevates IL-6 Expression via TLR4 Signaling in Oral Keratinocytes
Authors: Yáñez Lucas , Soto Cristopher , Tapia Héctor , Pacheco Martín , Tapia Javiera , Osses Gabriela , Salinas Daniela , Rojas-Celis Victoria , Hoare Anilei , Quest Andrew F. G. , Díaz-Elizondo Jessica , Pérez-Donoso José Manuel , Bravo Denisse
Published: March 2024

Periodontitis, characterized by persistent inflammation in the periodontium, is intricately connected to systemic diseases, including oral cancer. Bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, play a pivotal role in periodontitis development because they contribute to dysbiosis and tissue destruction. Thus, comprehending the interplay between these bacteria and their impacts on inflammation holds significant relevance in clinical understanding and treatment advancement. In the present work, we explored, for the first time, their impacts on the expressions of pro-inflammatory mediators after infecting oral keratinocytes (OKs) with a co-culture of pre-incubated P. gingivalis and F. nucleatum. Our results show that the co-culture increases IL-1β, IL-8, and TNF-α expressions, synergistically augments IL-6, and translocates NF-kB to the cell nucleus. These changes in pro-inflammatory mediators—associated with chronic inflammation and cancer—correlate with an increase in cell migration following infection with the co-cultured bacteria or P. gingivalis alone. This effect depends on TLR4 because TLR4 knockdown notably impacts IL-6 expression and cell migration. Our study unveils, for the first time, crucial insights into the outcomes of their co-culture on virulence, unraveling the role of bacterial interactions in polymicrobial diseases and potential links to oral cancer.
Oxidative Stress Markers and Histopathological Changes in Selected Organs of Mice Infected with Murine Norovirus 1 (MNV-1)
Authors: Janicka Paulina , Stygar Dominika , Chełmecka Elżbieta , Kuropka Piotr , Miążek Arkadiusz , Studzińska Aleksandra , Pogorzelska Aleksandra , Pala Katarzyna , Bażanów Barbara
Published: March 2024

This paper describes the effects of murine norovirus (MNV) infection on oxidative stress and histopathological changes in mice. This study uses histopathological assays, enzymatic and non-enzymatic antioxidant markers, and total oxidative status and capacity (TOS, TAC). The results suggest that MNV infection can lead to significant changes with respect to the above-mentioned parameters in various organs. Specifically, reduced superoxide dismutase (SOD), Mn superoxide dismutase (MnSOD), catalase (CAT), and glutathione reductase (GR) activities were observed in liver tissues, while higher MnSOD activity was observed in kidney tissues of MNV-infected mice when compared to the control. GR activity was lower in all tissues of MNV-infected mice tested, with the exception of lung tissue. This study also showed that norovirus infection led to increased TOS levels in the brain and liver and TAC levels in the brain, while TOS levels were significantly reduced in the kidneys. These changes may be due to the production of reactive oxygen species (ROS) caused by the viral infection. ROS can damage cells and contribute to oxidative stress. These studies help us to understand the pathogenesis of MNV infection and its potential effects on oxidative stress and histopathological changes in mice, and pave the way for further studies of the long-term effects of MNV infection.
Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review
Authors: Nappi Francesco
Published: March 2024

The use of non-coding RNAs (ncRNAs) as drug targets is being researched due to their discovery and their role in disease. Targeting ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is an attractive approach for treating various diseases, such as cardiovascular disease and cancer. This seminar discusses the current status of ncRNAs as therapeutic targets in different pathological conditions. Regarding miRNA-based drugs, this approach has made significant progress in preclinical and clinical testing for cardiovascular diseases, where the limitations of conventional pharmacotherapy are evident. The challenges of miRNA-based drugs, including specificity, delivery, and tolerability, will be discussed. New approaches to improve their success will be explored. Furthermore, it extensively discusses the potential development of targeted therapies for cardiovascular disease. Finally, this document reports on the recent advances in identifying and characterizing microRNAs, manipulating them, and translating them into clinical applications. It also addresses the challenges and perspectives towards clinical application.
Enhanced Therapeutic Potential of Hybrid Exosomes Loaded with Paclitaxel for Cancer Therapy
Authors: Wang Xuan , Li Dongdong , Li Gaotian , Chen Jinda , Yang Yi , Bian Lijun , Zhou Jingying , Wu Yongge , Chen Yan
Published: March 2024

The advancement of exosome studies has positioned engineered exosomes as crucial biomaterials for the development of advanced drug delivery systems. This study focuses on developing a hybrid exosome system by fusing mesenchymal stem cells (MSCs) exosomes with folate-targeted liposomes. The aim was to improve the drug loading capacity and target modification of exosome nanocarriers for delivering the first-line chemotherapy drug paclitaxel (PTX) and its effectiveness was assessed through cellular uptake studies to evaluate its ability to deliver drugs to tumor cells in vitro. Additionally, in vivo experiments were conducted using a CT26 tumor-bearing mouse model to assess the therapeutic efficacy of hybrid exosomes loaded with PTX (ELP). Cellular uptake studies demonstrated that ELP exhibited superior drug delivery capabilities to tumor cells in vitro. Moreover, in vivo experiments revealed that ELP significantly suppressed tumor growth in the CT26 tumor-bearing mouse model. Notably, for the first time, we examined the tumor microenvironment following intratumoral administration of ELP. We observed that ELP treatment activated CD4+ and CD8+ T cells, reduced the expression of M2 type tumor-associated macrophages (TAMs), polarized TAMs towards the M1 type, and decreased regulatory T cells (Tregs). Our research highlights the considerable therapeutic efficacy of ELP and its promising potential for future application in cancer therapy. The development of hybrid exosomes presents an innovative approach to enhance drug delivery and modulate the tumor microenvironment, offering exciting prospects for effective cancer treatment strategies.
Exploring the Impact of Alternative Sources of Dietary Nitrate Supplementation on Exercise Performance
Authors: Jędrejko Maciej , Jędrejko Karol , Gómez-Renaud Víctor M. , Kała Katarzyna , Muszyńska Bożena
Published: March 2024

An increase in the level of nitric oxide (NO) plays a key role in regulating the human cardiovascular system (lowering blood pressure, improving blood flow), glycemic control in type 2 diabetes, and may help enhance exercise capacity in healthy individuals (including athletes). This molecule is formed by endogenous enzymatic synthesis and the intake of inorganic nitrate (NO3−) from dietary sources. Although one of the most well-known natural sources of NO3− in the daily diet is beetroot (Beta vulgaris), this review also explores other plant sources of NO3− with comparable concentrations that could serve as ergogenic aids, supporting exercise performance or recovery in healthy individuals. The results of the analysis demonstrate that red spinach (Amaranthus spp.) and green spinach (Spinacia oleracea) are alternative natural sources rich in dietary NO3−. The outcomes of the collected studies showed that consumption of selected alternative sources of inorganic NO3− could support physical condition. Red spinach and green spinach have been shown to improve exercise performance or accelerate recovery after physical exertion in healthy subjects (including athletes).
SMA20/PMIS2 Is a Rapidly Evolving Sperm Membrane Alloantigen with Possible Species-Divergent Function in Fertilization
Authors: Cormier Nathaly , Worsham Asha E. , Rich Kinsey A. , Hardy Daniel M.
Published: March 2024

Immunodominant alloantigens in pig sperm membranes include 15 known gene products and a previously undiscovered Mr 20,000 sperm membrane-specific protein (SMA20). Here we characterize SMA20 and identify it as the unannotated pig ortholog of PMIS2. A composite SMA20 cDNA encoded a 126 amino acid polypeptide comprising two predicted transmembrane segments and an N-terminal alanine- and proline (AP)-rich region with no apparent signal peptide. The Northern blots showed that the composite SMA20 cDNA was derived from a 1.1 kb testis-specific transcript. A BLASTp search retrieved no SMA20 match from the pig genome, but it did retrieve a 99% match to the Pmis2 gene product in warthog. Sequence identity to predicted PMIS2 orthologs from other placental mammals ranged from no more than 80% overall in Cetartiodactyla to less than 60% in Primates, with the AP-rich region showing the highest divergence, including, in the extreme, its absence in most rodents, including the mouse. SMA20 immunoreactivity localized to the acrosome/apical head of methanol-fixed boar spermatozoa but not live, motile cells. Ultrastructurally, the SMA20 AP-rich domain immunolocalized to the inner leaflet of the plasma membrane, the outer acrosomal membrane, and the acrosomal contents of ejaculated spermatozoa. Gene name search failed to retrieve annotated Pmis2 from most mammalian genomes. Nevertheless, individual pairwise interrogation of loci spanning Atp4a–Haus5 identified Pmis2 in all placental mammals, but not in marsupials or monotremes. We conclude that the gene encoding sperm-specific SMA20/PMIS2 arose de novo in Eutheria after divergence from Metatheria, whereupon rapid molecular evolution likely drove the acquisition of a species-divergent function unique to fertilization in placental mammals.
Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia
Authors: Tregub Pavel P. , Kulikov Vladimir P. , Ibrahimli Irada , Tregub Oksana F. , Volodkin Artem V. , Ignatyuk Michael A. , Kostin Andrey A. , Atiakshin Dmitrii A.
Published: March 2024

The review introduces the stages of formation and experimental confirmation of the hypothesis regarding the mutual potentiation of neuroprotective effects of hypoxia and hypercapnia during their combined influence (hypercapnic hypoxia). The main focus is on the mechanisms and signaling pathways involved in the formation of ischemic tolerance in the brain during intermittent hypercapnic hypoxia. Importantly, the combined effect of hypoxia and hypercapnia exerts a more pronounced neuroprotective effect compared to their separate application. Some signaling systems are associated with the predominance of the hypoxic stimulus (HIF-1α, A1 receptors), while others (NF-κB, antioxidant activity, inhibition of apoptosis, maintenance of selective blood–brain barrier permeability) are mainly modulated by hypercapnia. Most of the molecular and cellular mechanisms involved in the formation of brain tolerance to ischemia are due to the contribution of both excess carbon dioxide and oxygen deficiency (ATP-dependent potassium channels, chaperones, endoplasmic reticulum stress, mitochondrial metabolism reprogramming). Overall, experimental studies indicate the dominance of hypercapnia in the neuroprotective effect of its combined action with hypoxia. Recent clinical studies have demonstrated the effectiveness of hypercapnic–hypoxic training in the treatment of childhood cerebral palsy and diabetic polyneuropathy in children. Combining hypercapnic hypoxia with pharmacological modulators of neuro/cardio/cytoprotection signaling pathways is likely to be promising for translating experimental research into clinical medicine.
Quantum Convolutional Long Short-Term Memory Based on Variational Quantum Algorithms in the Era of NISQ
Authors: Xu Zeyu , Yu Wenbin , Zhang Chengjun , Chen Yadang
Published: March 2024

In the era of noisy intermediate-scale quantum (NISQ) computing, the synergistic collaboration between quantum and classical computing models has emerged as a promising solution for tackling complex computational challenges. Long short-term memory (LSTM), as a popular network for modeling sequential data, has been widely acknowledged for its effectiveness. However, with the increasing demand for data and spatial feature extraction, the training cost of LSTM exhibits exponential growth. In this study, we propose the quantum convolutional long short-term memory (QConvLSTM) model. By ingeniously integrating classical convolutional LSTM (ConvLSTM) networks and quantum variational algorithms, we leverage the variational quantum properties and the accelerating characteristics of quantum states to optimize the model training process. Experimental validation demonstrates that, compared to various LSTM variants, our proposed QConvLSTM model outperforms in terms of performance. Additionally, we adopt a hierarchical tree-like circuit design philosophy to enhance the model’s parallel computing capabilities while reducing dependence on quantum bit counts and circuit depth. Moreover, the inherent noise resilience in variational quantum algorithms makes this model more suitable for spatiotemporal sequence modeling tasks on NISQ devices.
STAR-3D: A Holistic Approach for Human Activity Recognition in the Classroom Environment
Authors: Sharma Vijeta , Gupta Manjari , Kumar Ajai , Mishra Deepti
Published: March 2024

The video camera is essential for reliable activity monitoring, and a robust analysis helps in efficient interpretation. The systematic assessment of classroom activity through videos can help understand engagement levels from the perspective of both students and teachers. This practice can also help in robot-assistive classroom monitoring in the context of human–robot interaction. Therefore, we propose a novel algorithm for student–teacher activity recognition using 3D CNN (STAR-3D). The experiment is carried out using India’s indigenously developed supercomputer PARAM Shivay by the Centre for Development of Advanced Computing (C-DAC), Pune, India, under the National Supercomputing Mission (NSM), with a peak performance of 837 TeraFlops. The EduNet dataset (registered under the trademark of the DRSTATM dataset), a self-developed video dataset for classroom activities with 20 action classes, is used to train the model. Due to the unavailability of similar datasets containing both students’ and teachers’ actions, training, testing, and validation are only carried out on the EduNet dataset with 83.5% accuracy. To the best of our knowledge, this is the first attempt to develop an end-to-end algorithm that recognises both the students’ and teachers’ activities in the classroom environment, and it mainly focuses on school levels (K-12). In addition, a comparison with other approaches in the same domain shows our work’s novelty. This novel algorithm will also influence the researcher in exploring research on the “Convergence of High-Performance Computing and Artificial Intelligence”. We also present future research directions to integrate the STAR-3D algorithm with robots for classroom monitoring.
Assessment of Attractant Combinations for the Management of Red Palm Weevils (Rhynchophorus ferrugineus) in the United Arab Emirates
Authors: Na Su-Mi , Im Gue-Il , Lee Woon-Seok , Kim Dong-Gun
Published: March 2024

This study examined red palm weevil ecology in the United Arab Emirates to develop effective food baits, pheromone, and eco-friendly trapping methods. Three phases of investigation were conducted (from June to December 2023) on date palm farms in Ras Al Khaimah and Abu Dhabi. The first two phases, each 15 days long, were conducted in Ras Al Khaimah, whereas the third phase, 18 days long, was conducted in Abu Dhabi. Chemical attractants, such as existing pheromones and ethyl acetate, a newly synthesized ferruginol pheromone, and food baits, such as original dates, date paste, coconut water, and date palm syrup, were used to attract the weevils. Multi-funnel traps containing various attractant mixes were tested. The main activity of the red palm weevils was observed from 3:00 to 6:00 a.m., with 85.72 ± 3.39% being captured during this period, coinciding with cooler temperatures. When pheromones were added to the food bait, the capture rate increased by 6.95 ± 1.81 times. Combining food bait, ethyl acetate, and pheromones improved the capture rates by 3.14 ± 0.69 times compared to pheromones alone. The newly synthesized pheromone achieved capture rates 2.69 ± 0.07 times higher than those of the commercially available pheromone, confirming its suitability as a red palm weevil attractant.
Impact of Chemical Insecticide Application on Beneficial Insects in Maize
Authors: Camerini Giuseppe , Maini Stefano , Limonta Lidia
Published: March 2024

The European corn borer (ECB) (Ostrinia nubilalis Hübner) and to a lesser extent the western corn rootworm (Diabrotica virgifera virgifera LeConte) are a threat to maize in the Po Valley (Northern Italy), and their control can require insecticide applications. The results of a study to evaluate the effects of insecticide sprays on the beneficial insect Trichogramma brassicae (Hymenoptera: Trichogrammatidae) and aphid predators are reported. A three-year research project was carried out in two Study Areas, in Lombardy. In area 1, crop rotation was a common practice, while in area 2 repeated maize crop was practiced. The natural trend of ECB egg masses attacked by T. brassicae was affected and parasitism rates were reduced as a result of insecticide exposure (chlorpyriphos methyl, cypermethrin, alphacypermethrine). Repeated maize crop and insecticides spraying increased the abundance of the aphid population and negatively affected the aphid predator community, which mainly included ladybirds, hoverflies, true bugs and lacewings. The predator community was dominated by hoverflies in sprayed fields managed according to repeated maize crop protocols, whereas ladybirds and Orius spp. dominated in maize fields managed according to crop rotation protocols. Crop rotation protocols help to prevent ECB outbreaks; when the risk of exceeding the economic threshold limit is high, and this may be the case when maize is cultivated for seeds or for horticultural crops such as sweet corn, inundative release of T. brassicae and/or microbial control (i.e., use of Bacillus thuringiensis preparations) can integrate natural biocontrol, and provide a valuable alternative to chemical insecticides.
The Imaging X-ray Polarimetry Explorer (IXPE) and New Directions for the Future
Authors: Soffitta Paolo
Published: March 2024

An observatory dedicated to X-ray polarimetry has been operational since 9 December 2021. The Imaging X-ray Polarimetry Explorer (IXPE), a collaboration between NASA and ASI, features three X-ray telescopes equipped with detectors sensitive to linear polarization set to 120°. This marks the first instance of a three-telescope SMEX mission. Upon reaching orbit, an extending boom was deployed, extending the optics and detector to a focal length of 4 m. IXPE targets each celestial source through dithering observations. This method is essential for supporting on-ground calibrations by averaging the detector’s response across a section of its sensitive plane. The spacecraft supplies power, enables attitude determination for subsequent on-ground attitude reconstruction, and issues control commands. After two years of observation, IXPE has detected significant linear polarization from nearly all classes of celestial sources emitting X-rays. This paper outlines the IXPE mission’s achievements after two years of operation in orbit. In addition, we report developments for future high-throughput X-ray optics that will have much smaller dead-times by using a new generation of Applied Specific Integrated Circuits (ASIC), and may provide 3D reconstruction of photo-electron tracks.
Coordinated, Centralized, and Simultaneous Control of Fast Charging Stations and Distributed Energy Resources
Authors: Brandao Dener A. de L. , Callegari João M. S. , Brandao Danilo I. , Pires Igor A.
Published: March 2024

The growing penetration of fast charging stations (FCSs) to electric vehicles (EVs) and distributed energy resources (DERs) in the electrical power system brings technical issue changes in the voltage profile throughout grid nodes and feeder current overload. The provision of ancillary services by DERs and FCSs arises as an appealing solution to reduce these adverse effects, enhancing the grid hosting capacity. The control of microgrids is essential for the coordinated implementation of these services. Although microgrid control is widely applied to DERs, few studies address the coordinated control of DERs and FCSs to obtain benefits for the electrical power system. This paper proposes a coordinated and simultaneous control of DERs and FCSs based on the power-based control (PBC) strategy, efficiently exploiting FCSs in a microgrid model previously unaddressed in the literature. The results show that, with the coordinated control of DERs and FCSs, the control of the power flow in a minigrid (MG) is achieved both in moments of high generation and in moments of high load, even with the maximum operation of DERs. This method allows for the maintenance of voltage levels within values considered acceptable by technical standards (above 0.93 pu). The maintenance of voltage levels is derived from reducing the overload on the point of common coupling (PCC) of the minigrid by 28%, performing the peak shaving ancillary service. Furthermore, the method allows for the control of zero power flow in the PCC of the minigrid with the upstream electric grid in periods of high generation, performing the ancillary service of valley filling. The method performs this control without compromising vehicle recharging and power dispatch by DERs.
The Effect of Hospital-Based Liquid Diet and Commercial Formulas on Laboratory Parameters and Postoperative Complications in Patients with Head and Neck Cancer
Authors: Chloupek Aldona , Jurkiewicz Dariusz
Published: March 2024

Background: Patients with head and neck cancer (HNC) are at high risk of malnutrition. The aim of this study was to compare the effect of polymeric formulas available commercially and a high-protein liquid diet prepared in the hospital on laboratory parameters and postoperative complications in patients undergoing surgery for HNC. Methods: This single-center retrospective study included 149 patients who underwent surgery for HNC between 2008 and 2017. The following data were collected: patient and tumor characteristics, postoperative complications, and laboratory parameters measured at baseline and after surgery, including creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and blood glucose levels. Correlations between the duration of enteral nutrition and blood parameters were assessed. Results: After surgery, patients receiving commercial formulas had lower creatinine and blood glucose levels and higher ALT and ASP levels than those on the hospital-based diet. The longer duration of feeding with commercial formulas before surgery was associated with enhanced preoperative levels of ALT and ASP and with lower postoperative blood glucose. Patients on the hospital-based diet had a higher rate of postoperative complications than those receiving commercial formulas (16.1% vs. 3.3%). Conclusions: There were no clinically important differences in blood parameters among patients with HNC depending on the type of preparations used for enteral feeding. However, increased levels of liver enzymes in patients fed with commercial formulas were notable. The early initiation of enteral nutrition before surgery helped achieve normal blood glucose levels after surgery. The use of commercial preparations contributed to reducing the number and incidence of postoperative complications.
Continuous Superior Trunk Block versus Single-Shot Superior Trunk Block with Intravenous Dexmedetomidine for Postoperative Analgesia in Arthroscopic Shoulder Surgery: A Prospective Randomized Controlled Trial
Authors: Lee Bora , Jang Jaewon , Lim Joon-Ryul , Kim Eun Jung , Kim Donghu , Chun Yong-Min , Choi Yong Seon
Published: March 2024

Background/Objectives: Intravenous dexmedetomidine (DEX) can increase the analgesia duration of peripheral nerve block; however, its effect in combination with superior trunk block (STB) remains unclear. We examined whether combining single-shot STB (SSTB) with intravenous DEX would provide noninferior postoperative analgesia comparable to that provided by continuous STB (CSTB). Methods: Ninety-two patients scheduled for elective arthroscopic rotator cuff repair were enrolled in this prospective randomized trial. Patients were randomly assigned to the CSTB or SSTB + DEX group. Postoperatively, each CSTB group patient received 15 mL of 0.5% ropivacaine and a continuous 0.2% ropivacaine infusion. Each SSTB group patient received a 15 mL postoperative bolus injection of 0.5% ropivacaine. DEX was administered at 2 mcg/kg for 30 min post anesthesia, then maintained at 0.5 mcg/kg/h till surgery ended. Pain scores were investigated every 12 h for 48 h post operation, with evaluation of rebound pain incidence and opioid consumption. Results: The SSTB + DEX group had significantly higher median pain scores at 12 h post operation (resting pain, 8.0 vs. 3.0; movement pain, 8.0 vs. 5.0) and a higher incidence of rebound pain (56% vs. 20%) than the CSTB group. However, no significant between-group differences were observed in pain scores postoperatively at 24, 36, or 48 h. The CSTB group required less opioids and fewer rescue analgesics within 12–24 h post operation than the SSTB + DEX group. Conclusions: Compared with CSTB, SSTB + DEX required additional adjuvant or multimodal analgesics to reduce the risk and intensity of postoperative rebound pain in patients who underwent arthroscopic rotator cuff repair.
Predictive Value of Serial Model of End-Stage Liver Disease Score Determination in Patients with Postcardiotomy Extracorporeal Membrane Oxygenation
Authors: Sommerfeld Oliver , Neumann Caroline , Pfeifer Marcel-Dominic , Faerber Gloria , Kirov Hristo , von Loeffelholz Christian , Doenst Torsten , Sponholz Christoph
Published: March 2024

(1) Background: The use of extracorporeal membrane oxygenation (ECMO) in low cardiac output states after cardiac surgery may aid in patient recovery. However, in some patients, the clinical state may worsen, resulting in multiple organ failure and high mortality rates. In these circumstances, calculating a model of end-stage liver disease (MELD) score was shown to determine organ dysfunction and predicting mortality. (2) Methods: We evaluated whether serial MELD score determination increases mortality prediction in patients with postcardiotomy ECMO support. (3) Results: Statistically, a cutoff of a 2.5 MELD score increase within 48 h of ECMO initiation revealed an AUC of 0.722. Further, we found a significant association between hospital mortality and 48 h MELD increase (HR: 2.5, 95% CI: 1.33–4.75, p = 0.005) after adjustment for possible confounders. (4) Conclusions: Therefore, serial MELD score determinations on alternate days may be superior to single measurements in this special patient cohort.
The Use of Tenofovir Disoproxil Fumarate in the Management of eAg-Negative Chronic Hepatitis B Infection
Authors: Jagarlamudi Nishita , Reyes Melissa , Fung Scott , Wong Florence
Published: March 2024

Background/Objectives: Currently, there are insufficient data to recommend the treatment of patients with hepatitis B e antigen (HBeAg)-negative chronic infection who have normal ALT and low HBV DNA, since the prognosis is generally regarded as favorable. The aim of this pilot study was to determine whether the use of tenofovir disoproxil fumarate (TDF) 300 mg/day for 3 years was able to achieve functional cure (HBsAg loss) and HBsAg seroconversion in HBeAb-positive individuals. Methods: Fifty patients not on antiviral therapy (40% men, mean age 48.9 ± 10.9 years, 84% Asians) with minimal fibrosis were enrolled. Results: TDF reduced HBV DNA significantly to undetectable levels after 6 months. Overall, 48.3% of inactive carriers (baseline HBV DNA < 2000 IU/mL) remained HBV DNA negative 6 months after treatment withdrawal, which was significantly higher than the 5.6% in those who were not inactive carriers (baseline HBV DNA ≥ 2000 IU/mL) (p = 0.003). The HBsAg levels did not drop throughout the study period with no difference between inactive carriers versus those who were not. Five inactive carriers achieved functional cure, but none of these were amongst those who were not inactive carriers. No renal dysfunction or ALT flare on treatment withdrawal was observed. Conclusions: TDF could potentially be used to induce functional cure in patients who are inactive carriers with normal ALT, low HBV DNA and without advanced fibrosis.
Long-Term Treatment with the Calcitonin Gene-Related Peptide Receptor Antagonist Erenumab in CADASIL: Two Case Reports
Authors: Albanese Maria , Pescini Francesca , Di Bonaventura Chiara , Iannone Luigi Francesco , Bianchi Silvia , Poggesi Anna , Bengala Mario , Mercuri Nicola Biagio , De Cesaris Francesco
Published: March 2024

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of cerebral small vessel disease, caused by a mutation in the NOTCH3 gene on chromosome 19. The main clinical features include migraine (often with aura), early onset, recurrent subcortical ischemic strokes, mood disturbances, and cognitive impairment, frequently leading to dementia and disability with a reduction in life expectancy. Cerebral chronic global hypoperfusion, due to impaired cerebrovascular reactivity, seems to play a primary role in CADASIL. Migraine is the most common early feature of the disease, and to date, there are no consensus guidelines for treatment. Given the vasomodulatory influence of many antimigraine drugs, there is concern about their use in this disease. In particular, the calcitonin gene-related peptide (CGRP) system serves as a vasodilatory protective mechanism during cerebral and cardiac ischemia. Blocking this system could exacerbate ischemic events. Herein, we describe two CADASIL patients who were treated with the calcitonin gene-related peptide (CGRP) receptor antagonist erenumab for chronic migraine, reporting a significant reduction in the frequency of attacks and intensity of pain, and an improvement in quality of life without adverse effects.
The Effect of Platelet-Rich Fibrin and Platelet-Rich Plasma in Secondary Alveolar Bone Grafting in Cleft Lip and Palate Patients: A Systematic Review
Authors: Thangarajah Showbanaa , Nordin Rifqah , Tan Huann Lan , Soh Hui Yuh , Nabil Syed
Published: March 2024

(1) Background: Cleft lip, alveolus, and palate are the most common congenital abnormalities in the world, occurring in one in seven hundred live births. Secondary alveolar bone grafting (SABG) is usually performed when the permanent canine root shows one-half to two-thirds of root development. To improve the surgical outcome, supplemental grafting materials such as platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) have been used as an adjunct. This review is designed to assess the efficacy of PRF and PRP in improving the outcome of SABG. (2) Methods: A comprehensive literature search was performed until 13 October 2022 on MEDLINE, EMBASE, The Cochrane Library, and Pubmed. The full text of potentially relevant studies was reviewed, and only randomised clinical trials (RCTs) were included based on the inclusion criteria. (3) Results: A total of 656 studies were screened, of which four were included for final review. All of the four included studies that evaluated the quantitative or qualitative surgical outcome in varied ways. (4) Conclusions: Results of this review suggest that both PRF or PRP and control group (without the use of PRF/PRP) achieved similar successful outcomes in bone height, bone density, and bone volume in both qualitative and quantitative assessment.
ScriptBlock Smuggling: Uncovering Stealthy Evasion Techniques in PowerShell and .NET Environments
Authors: Rose Anthony J. , Graham Scott R. , Schubert Kabban Christine M. , Krasnov Jacob J. , Henry Wayne C.
Published: March 2024

The Antimalware Scan Interface (AMSI) plays a crucial role in detecting malware within Windows operating systems. This paper presents ScriptBlock Smuggling, a novel evasion and log spoofing technique exploiting PowerShell and .NET environments to circumvent the AMSI. By focusing on the manipulation of ScriptBlocks within the Abstract Syntax Tree (AST), this method creates dual AST representations, one for compiler execution and another for antivirus and log analysis, enabling the evasion of AMSI detection and challenging traditional memory patching bypass methods. This research provides a detailed analysis of PowerShell’s ScriptBlock creation and its inherent security features and pinpoints critical limitations in the AMSI’s capabilities to scrutinize ScriptBlocks and the implications of log spoofing as part of this evasion method. The findings highlight potential avenues for attackers to exploit these vulnerabilities, suggesting the possibility of a new class of AMSI bypasses and their use for log spoofing. In response, this paper proposes a synchronization strategy for ASTs, intended to unify the compilation and malware scanning processes to reduce the threat surfaces in PowerShell and .NET environments.
Effects of Poly(Vinylidene Fluoride-co-Hexafluoropropylene) Nanocomposite Membrane on Reduction in Microbial Load and Heavy Metals in Surface Water Samples
Authors: Macevele Lutendo Evelyn , Moganedi Kgabo Lydia Maureen , Magadzu Takalani
Published: March 2024

In this work, nanocomposite membranes were prepared using silver nanoparticles (Ag) attached to poly(amidoamine) dendrimer (P)-functionalised multi-walled carbon nanotubes (CNTs) blended with poly(vinylidene fluoride-co-hexafluoropropene) (PVDF-HFP) polymeric membranes (i.e., AgP-CNT/PVDF-HFP) via the phase inversion method. The nanocomposites were characterised and analysed via transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDX), thermal gravimetric analysis (TGA) and Brunauer–Emmett–Teller (BET) analysis. The TEM and EDX analyses confirmed the presence of Ag nanoparticles on the nanocomposites, while the SEM and BET data showed the spongy morphology of the nanocomposite membranes with improved surface areas. The sample analysis of surface water collected from the Sekhukhune district, Limpopo Province, South Africa indicated that the water could not be used for human consumption without being treated. The nanocomposite membranes significantly reduced the physicochemical parameters of the sampled water, such as turbidity, TSS, TDS and carbonate hardness, to 4 NTU, 7 mg/L, 7.69 mg/L and 5.9 mg/L, respectively. Significant improvements in microbial load (0 CFU/mL) and BOD (3.0 mg/L) reduction were noted after membrane treatment. Furthermore, toxic heavy metals such as chromium, cadmium and nickel were remarkably reduced to 0.0138, 0.0012 and 0.015 mg/L, respectively. The results clearly suggest that the AgP-CNT/PVDF-HFP nanocomposite membrane can be used for surface water treatment.
A Comparative Study between a Thermal Spray CoCrFeMnNi0.8V/WC-Co High Entropy Alloy Composite Coating and Plain CoCrFeMnNi0.8V and WC-Co Thermal Spray Coatings
Authors: Kiape Stavros , Glava Maria , Georgatis Emmanuel , Kamnis Spyros , Matikas Theodore E. , Karantzalis Alexandros E.
Published: March 2024

High entropy alloys (HEAs) have emerged as a frontier in surface engineering, challenging the status quo of traditional alloy systems with their exceptional mechanical properties and corrosion resistance. This study investigates the CoCrFeMnNi0.8V HEA, both as a standalone alloy and in a composite with WC-Co, to evaluate their potential as innovative surface coatings. The CoCrFeMnNi0.8V alloy, enriched with vanadium, demonstrates a unique microstructure with enhanced hardness and wear resistance, while the addition of WC-Co particles contributes to improved toughness and durability. By employing High Velocity Oxy-Fuel (HVOF) thermal spray techniques, coatings are deposited onto steel substrates and subjected to rigorous microstructural characterization, wear, and corrosion resistance testing. The results reveal that the CoCrFeMnNi0.8V coating exhibits impressive corrosion resistance in chloride-rich environments. The composite coating leverages the synergy between the HEA’s inherent corrosion resistance and WC-Co’s wear resistance, striking a balance that suits demanding applications. With optimized processing conditions, the composite WC-Co-reinforced high entropy alloy coating could offer a significant advancement in protective coatings technology, especially for maritime and other corrosive settings. This work not only underscores the versatility of HEAs in surface engineering applications but also opens avenues for the development of new material mixtures.
Applications of Cu2+-Loaded Silica Nanoparticles to Photothermal Therapy and Tumor-Specific Fluorescence Imaging
Authors: Park Ji-Ho , Sung Yejin , Jo SeongHoon , Lee Seung Ho , Ryu Ju Hee , Sun In-Cheol , Ahn Cheol-Hee
Published: March 2024

Copper-based nanomaterials have been employed as therapeutic agents for cancer therapy and diagnosis. Nevertheless, persistent challenges, such as cellular toxicity, non-uniform sizes, and low photothermal efficiency, often constrain their applications. In this study, we present Cu2+-loaded silica nanoparticles fabricated through the chelation of Cu2+ ions by silanol groups. The integration of Cu2+ ions into uniformly sized silica nanoparticles imparts a photothermal therapy effect. Additionally, the amine functionalization of the silica coating facilitates the chemical conjugation of tumor-specific fluorescence probes. These probes are strategically designed to remain in an ‘off’ state through the Förster resonance energy transfer mechanism until exposed to cysteine enzymes in cancer cells, inducing the recovery of their fluorescence. Consequently, our Cu2+-loaded silica nanoparticles demonstrate an efficient photothermal therapy effect and selectively enable cancer imaging.
An Improved Bio-Orientation Method Based on Direct Sunlight Compensation for Imaging Polarization Sensor
Authors: Li Guangmin , Zhang Ya , Fan Shiwei , Yu Fei
Published: March 2024

Direct sunlight in complex environmental conditions severely interferes with the light intensity response for imaging Polarization Sensor (PS), leading to a reduction in polarization orientation accuracy. Addressing this issue, this article analyzes the impact mechanism of direct sunlight on polarization sensor detection in a complex environment. The direct sunlight interference factor is introduced into the intensity response model of imaging polarization detection, enhancing the accuracy of the polarization detection model. Furthermore, a polarization state information analytical solution model based on direct sunlight compensation is constructed to improve the accuracy and real-time performance of the polarization state information solution. On this basis, an improved bio-orientation method based on direct sunlight compensation for imaging polarization sensor is proposed. The outdoor dynamic reorientation experiment platform is established to validate the effectiveness of the proposed method. Compared with the traditional methods, the experimental results demonstrate a 23% to 47% improvement in the polarization orientation accuracy under various solar zenith angles.
An Efficient CNN-Based Method for Intracranial Hemorrhage Segmentation from Computerized Tomography Imaging
Authors: Hoang Quoc Tuan , Pham Xuan Hien , Trinh Xuan Thang , Le Anh Vu , Bui Minh V. , Bui Trung Thanh
Published: March 2024

Intracranial hemorrhage (ICH) resulting from traumatic brain injury is a serious issue, often leading to death or long-term disability if not promptly diagnosed. Currently, doctors primarily use Computerized Tomography (CT) scans to detect and precisely locate a hemorrhage, typically interpreted by radiologists. However, this diagnostic process heavily relies on the expertise of medical professionals. To address potential errors, computer-aided diagnosis systems have been developed. In this study, we propose a new method that enhances the localization and segmentation of ICH lesions in CT scans by using multiple images created through different data augmentation techniques. We integrate residual connections into a U-Net-based segmentation network to improve the training efficiency. Our experiments, based on 82 CT scans from traumatic brain injury patients, validate the effectiveness of our approach, achieving an IOU score of 0.807 ± 0.03 for ICH segmentation using 10-fold cross-validation.
Digital Image Correlation Structural Strain Analysis of S235 Fillet-Welded Joints under Low-Cycle Fatigue Loadings
Authors: Corigliano Pasqualino , Dong Pingsha
Published: March 2024

The main objectives of the present study were the application and validation of the newly proposed Digital Image Correlation equivalent structural strain approach for assessing the low-cycle fatigue life of S235 welded joints. Low-cycle fatigue tests were performed at a displacement ratio of minus one. Experimental tests were performed using two different ways of controlling the displacement amplitude: applying traditional low-cycle fatigue tests at a constant amplitude and stepwise succession tests at increasing amplitudes. A comprehensive, independent experimental procedure, proposed by the authors and not yet validated for steel welded joints, was applied to assess the equivalent structural strain range using the Digital Image Correlation technique for the traditional low-cycle fatigue tests and stepwise succession tests at increasing amplitudes. It is noteworthy that the values of the DIC equivalent structural strain (ΔEs from the DIC), calculated on the external sides of the samples, were utilized to predict fatigue life in correlation with the ASME mean curve and fall within the ±3σ scatter bands (external bands). In particular, most of the tests lie within the ±2σ boundary of the design curves except for some tests at low applied displacements. Moreover, it was shown that this method is applicable to stepwise succession tests with increasing displacement amplitudes, leading to significant time savings compared to conventional experimental tests.
Port State Control Inspections under the Paris Memorandum of Understanding and Their Contribution to Maritime Safety: Additional Risk Classifications and Indicators Using Multivariate Techniques
Authors: Almorza David , Prieto Jose Manuel , Amor-Esteban Víctor , Piniella Francisco
Published: March 2024

Port State Control (PSC) inspections conducted under the Paris Memorandum of Understanding (MoU) agreement have become a crucial tool for maritime administrations in European Union countries to ensure compliance with international maritime safety standards by ships entering their ports. This paper analyses all PSC inspections conducted in 10 major European ports belonging to the Paris MoU between 2012 and 2019. For its study, a multivariate HJ-Biplot statistical analysis is carried out, which facilitates the interpretation and understanding of the underlying relationships in a multivariate data set by representing a synthesis of the data on a factorial plane, with an interpretation that is very intuitive and accessible for readers from various fields. Applying this method with ship characteristics as explanatory variables, several classifications were derived. These classifications align with the annual performance lists published by the Paris MoU and the International Association of Classification Societies list, suggesting that this method could serve as a reliable classification approach. It provides maritime authorities with an additional indicator of a ship’s risk profile, aiding in the prioritising of inspections. The method also effectively categorises ports and types of ships used for cargo transport, offering insights into the specific maritime traffic each port experiences. Furthermore, this study identifies characteristics associated with substandard ships, which is a primary objective of PSC inspections. Beyond revealing these traits, this research underscores the existence of several readily applicable techniques to enhance maritime safety and reduce the risk of ocean pollution.