bluuebunny/crossref_metadata_2025 huggingface dataset:
The inducible secreting TLR5 agonist, CBLB502, enhances the anti-tumor activity of CAR133-NK92 cells in colorectal cancer
Authors: Wang Xiaohui , Qiu Wei , Liu Haoyu , He Min , He Wei , Li Zhan , Wu Zhiqiang , Xu Xiang , Chen Ping
Published: September 2023

Objective: CAR-T/NK cells have had limited success in the treatment of solid tumors, such as colorectal cancer (CRC), in part because of the heterogeneous nature of tumor-associated antigens that lead to antigen-negative relapse after the initial response. This barrier might be overcome by enhancing the recruitment and durability of endogenous immune cells. Methods: Immunohistochemistry and flow cytometry were used to assess the expression of CD133 antigen in tissue microarrays and cell lines, respectively. Retroviral vector transduction was used to generate CBLB502-secreting CAR133-NK92 cells (CAR133-i502-NK92). The tumor killing capacity of CAR133-NK92 cells in vitro and in vivo were quantified via LDH release, the RTCA assay, and the degranulation test, as well as measuring tumor bioluminescence signal intensity in mice xenografts. Results: We engineered CAR133-i502-NK92 cells and demonstrated that those cells displayed enhanced proliferation (9.0 × 104 cells vs. 7.0 × 104 cells) and specific anti-tumor activities in vitro and in a xenogeneic mouse model, and were well-tolerated. Notably, CBLB502 secreted by CAR133-i502-NK92 cells effectively activated endogenous immune cells. Furthermore, in hCD133+/hCD133− mixed cancer xenograft models, CAR133-i502-NK92 cells suppressed cancer growth better than the counterparts (n = 5, P = 0.0297). Greater T-cell infiltration was associated with greater anti-tumor potency (P < 0.0001). Conclusions: Armed with a CBLB502 TLR5 agonist, CAR133-NK92 cells were shown to be capable of specifically eliminating CD133-positive colon cancer cells in a CAR133-dependent manner and indirectly eradicating CD133-negative colon cancer cells in a CBLB502-specific endogenous immune response manner. This study describes a novel technique for optimizing CAR-T/NK cells for the treatment of antigenically-diverse solid tumors.
Exact Solution of Decaying Turbulence
Authors: Migdal Alexander
Published: September 2023

We have found an infinite dimensional manifold of exact solutions of the Navier-Stokes loop equation for the Wilson loop in decaying Turbulence in arbitrary dimension $d >2$. This solution family is equivalent to a fractal curve in complex space $\mathbb C^d$ with random steps parametrized by $N$ Ising variables $\sigma_i=\pm 1$, in addition to a rational number $\frac{p}{q}$ and an integer winding number $r$, related by $\sum \sigma_i = q r$. This equivalence provides a \textbf{dual} theory describing a strong turbulent phase of the Navier-Stokes flow in $\mathbb R_d$ space as a random geometry in a different space, like ADS/CFT correspondence in gauge theory. From a mathematical point of view, this theory implements a stochastic solution of the unforced Navier-Stokes equations. For a theoretical physicist, this is a \textbf{quantum} statistical system with integer-valued parameters, satisfying some number theory constraints. Its long-range interaction leads to critical phenomena when its size $N \rightarrow \infty$ or its chemical potential $\mu \rightarrow 0$. The system with fixed $N$ has different asymptotics at odd and even $N\rightarrow \infty$, but the limit $\mu \rightarrow 0$ is well defined. The energy dissipation rate is analytically calculated as a function of $\mu$ using methods of number theory. It grows as $\nu/\mu^2$ in the continuum limit $\mu \rightarrow 0$, leading to anomalous dissipation at $\mu \propto \sqrt{\nu} \to 0$. The same method is used to compute all the local vorticity distribution, which has no continuum limit but is renormalizable in the sense that infinities can be absorbed into the redefinition of the parameters. The small perturbation of the fixed manifold satisfies the linear equation we solved in a general form. This perturbation decays as $t^{-\lambda}$, where the anomalous dimensions $\lambda$ satisfy the spectral equation \eqref{spectralEq}. The spectrum becomes a continuum in the statistical limit $N \to \infty$, presumably leading to multifractal phenomena.
Fabrication and Performance of Diaphragm Headphones Based on Graphene and Graphene Nanocomposites
Authors: Hwang Shun-Fa , Liu Hsien-Kuang , Liao Wei-Chong , Cheng Yi Kai
Published: September 2023

The goal of this paper is to fabricate innovative diaphragm headphones using graphene oxide paper (GOP) and GOP/epoxy nanocomposites (GOPC). Initially, graphene oxide suspension is fabricated, and the vacuum filtration method is adopted to make GOP. Then vacuum bag molding is used to fabricate GOPC from GOP. Hot pressing and associated molds are adopted to fabricate line-indented (GOPC-L) or curve-indented patterns (GOPC-C) on the GOPC. The performance of one kind of GOP and three kinds of GOPC diaphragm headphones is analyzed based on their sound pressure level (SPL) curves achieved by the Soundcheck measurement system. There are four important processing parameters that will influence the performance of the diaphragm, including material type GOP versus GOPC, indented pattern type, sonication time on suspension, and graphene weight fraction in suspension. Compliances of various diaphragms are measured by the Klippel LPM laser measurement system. The results indicate that effects of sonication time and graphene weight fraction on SPL of GOP and GOPC headphones are in reverse, and this is associated with their difference on compliance (modulus), mass, damping ratio, and microstructure uniformity. Either GOPC-L or GOPC-C seems to improve the microstructure of the GOPC, and leads to better SPL performance. The correlation between the previous four factors and SPLs of four kinds of diaphragm headphones is proposed by using scanning electron microscope (SEM) to examine the microstructure of these diaphragms.
Research on Safety Risk Transfer in Subway Construction Based on Text Mining and Complex Networks
Authors: Wu Kunpeng , Zhang Jianshe , Huang Yanlong , Wang Hui , Li Hujun , Chen Huihua
Published: September 2023

Subway construction is often in a complex natural and human-machine operating environment, and that complicated setting leads to subway construction more prone to safety accidents, which can cause substantial casualties and monetary losses. Thus, it is necessary to investigate the safety risks of subway construction. The existing literature on the identification and assessment of subway construction safety risks(SCSR) is susceptible to the influence of subjective factors. Moreover, although existing studies have explored the interrelationships between different risks, these studies usually analyze the interrelationships of single risks, lack the study of risk chain transfer relationships, and fail to find out the key path of risk transfer. Therefore, this paper innovatively combines text mining, association rules and complex networks to deep mine subway construction safety incident reports and explore risk transfer process. Firstly, it uses text mining technology to identify subway construction safety risk; Then, association rules are introduced to explore the causal relationships among safety risk; Finally, the key safety risk and important transfer paths of subway construction safety accidents (SCSA) are obtained based on the complex network model. Research results show that (a) improper safety management, unimplemented safety subject responsibilities, violation of operation rules, non-perfect safety responsibilities system and insufficient safety education and training are the key safety risk in SCSA; (b) two shorter key risk transfer paths in the subway construction safety network can be obtained: insufficient safety education and training→lower safety awareness→violation of operation rules→safety accidents; insufficient safety checks or hidden trouble investigations→violation of operation rules→safety accidents; (c) in the process of risk transfer, the risk can be controlled by controlling the key nodes or cutting off the transfer path. The results of the study provide new ideas and methods for SCSR identification and influence element mining, which help safety managers propose accurate subway construction safety risk control measures.
MEMS Switched Triangular and U-Shaped Band-Stop Resonators for K-Band Operation
Authors: Marcelli Romolo , Sardi Giovanni Maria , Proietti Emanuela , Capoccia Giovanni , Iannacci Jacopo , Tagliapietra Girolamo , Giacomozzi Flavio
Published: September 2023

Triangular resonators re-shaped with the Sierpinski geometry and U-shaped resonators have been designed, linking them with single-pole-double-through (SPDT) RF MEMS switches to provide frequency tuning for potential applications in the K-Band. Prototypes of band-stop narrowband filters working around 20 GHz and 26 GHz, interesting for RADAR and satellite communications, have been studied in coplanar waveguide (CPW) configuration, and the tuning was obtained by switching between two paths of the devices loaded with different resonators. As a result, dual-band operation or fine-tuning can be obtained depending on the choice of the resonator, acting as a building block. The studied filters belong to the more general group of devices inspired by the metamaterial design.
Physics of Ice Nucleation and Antinucleation: Action of Antifreeze Proteins and Ice Nucleators
Authors: Melnik Bogdan S. , Glukhova Ksenia A. , Sokolova Evgeniya A. , Balalaeva Irina V. , Garbuzynskiy Sergiy O. , Finkelstein Alexei V.
Published: September 2023

Ice-binding proteins are crucial for adaptation of various organisms to low temperatures. Some of these, called antifreeze proteins, are usually thought to inhibit growth and/or recrystallization of ice crystals. However, prior to these events, ice must somehow appear in the organism, either coming from outside or forming inside through the nucleation process. Unlike most other works, our paper is focused on ice nucleation rather than the behavior of the already existing ice. The nucleation kinetics is studied both theoretically, with special attention paid to ice nucleation on ice-binding surfaces, and experimentally. For experimental studies, we use the ice-binding protein mIBP83, a previously constructed mutant of a spruce budworm Choristoneura fumiferana antifreeze protein. We show that mIBP83 does not affect the ice nucleation temperature in the buffer in test tubes, but hinders the impact of potent ice nucleators of various chemical natures, namely CuO powder and ice-nucleating bacteria Pseudomonas syringae. Additional experiments on human cells show that mIBP83 is concentrated in some regions, but only in cooled cells. Thus, the antifreeze protein not only binds to ice, but also blocks various sites that act or can act as ice nucleators. Such ice-preventing binding may be the crucial biological task of antifreeze proteins.
Estimation of Threshold Age for Cerebral Decline Using Sigmoidal Growth Model in Cross-Sectional Imaging Study
Authors: Kim Namhee , Heo Moonseong , Fleysher Roman , Sears Malka Z. , Lipton Michael L.
Published: September 2023

Backgrounds
Linear association has widely been assumed for prediction of aging-related fractional anisotropy (FA) decline in white matter of the brain. While useful for testing significance of the aging effect, it fails to identify a threshold age before and after which the age-FA association changes. Identification of such a threshold is often of clinical interest for timely intervention.
Methods
We employed a sigmoidal growth function to test a threshold effect in age triggering onset of cerebral decline in 21 white matter tracts, and compared its fitting performance to those of linear, and power regression. The study sample was a normal healthy cohort of 106 participants with ages in mid-life ranging from 18 to 60 years.
Results
Of the 21 white matter tracts analyzed, the posterior thalamic radiation showed better fit with sigmoidal curve model, compared to a linear or power regression. The estimated threshold age in years (95% confidence interval) were 47.2 (44.1-48.4).
Conclusion
While available evidence regarding the presence of a specific age threshold for cerebral decline in mid-life based on FA was limited, the posterior thalamic radiation exhibited a threshold age of 47.2. Beyond this age point, we observed a significant change in the FA risk pattern.
Wind Energy Investment in Greece: Case study of an Aegean Island
Authors: Ntanos Stamatios , Arabatzis Garyfallos , Drosos Dimitrios , Sparangis Polyzois , Lekaj Evangelia
Published: September 2023

Considering that traditional energy sources such as fossil fuel are about to deplete during the following decades, governments try to turn to renewable energy. It is commonly known that Greece has a natural advantage of abundant solar energy and wind power due to its geographical location and characteristics.The main focus of this study is to examine how wind energy potential across the Aegean Sea and continental Greece can provide a promising field for investments in Greece, considering the economic crisis, current trends and future perspectives.We firstly focus on current legislation framework considering that laws associated with such types of investment in Greece are very complex and rapidly changing. Furthermore, a case study for a hypothetical investment plan concerning a wind park located in an Aegean island will be presented. RetScreen which is a software made by the Canadian government, will be used as a decision support tool for analyzing the potential investment scenario and a financial report will follow with estimation of the overall cost, depreciation, upcoming benefits, and payback period of the investment.Data analysis concludes that wind parks still prove to be an economically viable investment, although incentives considering the guaranteed price per kwh and faster investment times must be provided by the government.
Temperature Dependency Model in Pressure Measurement for the Motion-Capturing Pressure-Sensitive Paint Method
Authors: Kurihara Daiki , Sakaue Hirotaka
Published: September 2023

Pressure-sensitive paint (PSP) has received significant attention for capturing surface pressure in recent years. One major source of uncertainty in PSP measurements, temperature dependency, stems from the fundamental photophysical process that allows PSP to extract pressure information. The motion-capturing PSP method, which involves two luminophores, is introduced as a method to reduce the measurement uncertainty due to temperature dependency. A theoretical model for the pressure uncertainty due to temperature dependency is proposed and demonstrated using a static pressure measurement with an applied temperature gradient. The experimental validation of the proposed model shows that the motion-capturing PSP method reduces the temperature dependency by 37.7% compared to the conventional PSP method. The proposed model also proves that a PSP with zero temperature dependency is theoretically possible.
Identification of Multiple Novel Viruses in Fecal Samples of Black-necked Cranes using Viral Metagenomics Methods
Authors: Zhao Qifan , Zhao Ran , Sun Yijie , Ji Li , Xi Yuan , Wang Xiaochun , Shen Quan , Ji Likai , Wang Yan , You Zhenqiang , Yang Shixing , Zhang Wen
Published: September 2023

The black-necked crane is the only species that lives in the plateau. At present, there is little re-search on viral diseases of the black-necked crane. In this study, a virus metagenomics approach was employed to investigate the viral composition of black-necked cranes in Saga County, Shi-gatse City, Tibet, China. The identified virus families carried by black-necked cranes mainly in-clude Genomoviridae, Parvoviridae, and Picornaviridae. Among them, one picornavirus genome is characterized as a novel species in the genus Grusopivirus of the family Picornaviridae, four new parvoviruses genome were obtained and classified into four different novel species within the genus Chaphamaparvovirus of the subfamily Hamaparvovirinae, and four novel genomoviruses ge-nome were also acquired and identified as members of three different species including Ge-mykroznavirus haeme1, Gemycircularvirus ptero6, and Gemycircularvirus ptero10. All of these viruses were firstly detected in fecal samples of black-necked cranes. This study provides valuable in-formation for understanding the viral community composition in the digestive tract of black-necked cranes in Tibet and for monitoring, preventing, and treating black-necked cranes viral diseases.
Gene Expression Analysis Reveals the Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus Positive Cervical Cancer Cell Lines
Authors: Cakir Muharrem Okan , Bilge Ugur , Ghanbari Arshia , Ashrafi G Hossein
Published: September 2023

Cervical cancer presents a significant global health concern with high-risk human papilloma-viruses (HPVs) being identified as the cause of this cancer. Although current treatment methods for cervical cancer can eliminate lesions, preventing metastatic spread and minimizing tissue damage remains a major challenge. Therefore, the development of a safer and innovative thera-peutic approach is of utmost importance. Natural products like Fig latex, derived from the Ficus Carica tree, have demonstrated promising anti-cancer properties when tested on cervical cancer cell lines. However, the specific mechanisms by which Fig latex exerts its effects are still un-known. In this study, we conducted RNA-seq analysis to explore how Fig latex may counteract carcinogenesis in HPV-positive cervical cancer cell lines, namely CaSki (HPV type 16-positive) and HeLa (HPV type 18-positive). Our data from this investigation indicates that Fig latex influ-ences the expression of genes associated with the development and progression of cervical can-cer, including pathways related to " Nonsense-Mediated Decay (NMD) "cell cycle regulation" and Transcriptional Regulation by TP53. This selective impact of Fig latex on cancer-related pathways suggests a potential novel therapeutic approach for HPV-related cervical cancer.
Meckel’s Diverticulum Causing Ileal Volvulus and Peritonitis after a Recent Appendectomy: Case Report and Review of Literature – Should We Resect an Incidental One?
Authors: Zanchetta Matteo , Inversini Davide , Pappalardo Vincenzo , Grappolini Niccolo , Morabito Marika , Gianazza Simone , Carcano Giulio , Ietto Giuseppe
Published: September 2023

Meckel’s diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract with a 1-3% prevalence in general population. The surgical management of symptomatic MD is well described in the literature, but there is still no consensus on the indication for prophylactic resection of incidental asymptomatic MD. To address this issue, we extensively reviewed the current literature and report our experience with laparoscopic management of an unusual case of MD causing ileal volvulus and acute peritonitis two weeks after a laparoscopic appendectomy for acute gangrenous appendicitis performed in another hospital. A 50-year-old man presented to the emergency department with acute and severe abdominal pain, vomiting and constipation. He had undergone a laparoscopic appendectomy for acute appendicitis two weeks before in another hospital. The patient was apyretic, distressed, and sought an antalgic position. The abdomen was mildly distended, tender, and the Blumberg sign was mildly positive in the central quadrants. The clinical picture deteriorated with fever, peritonismus, and leukocytosis. A CT scan showed an ileo-ileal adhesion near the ileocolic junction and dilatation of the upstream loops with air-fluid levels. Through an urgent laparoscopy, a necrotic mass, the MD, was wedge-resected and the surrounding ileal volvulus derotated. The postoperative course was uneventful. There is no definitive consensus on the appropriate management of incidental asymptomatic MD, although several studies have attempted to identify guiding criteria. Features of the MD, patient’s risk factors, clinical presentation, and surgical approach need to be considered to establish definitive guidelines for the management of incidental asymptomatic MD. In the absence of definitive guidelines, personal expertise and judgement are the main resources for the surgeon approaching an incidental asymptomatic MD.
Regulatory ILC2 – Role of IL-10 Producing ILC2 in Asthma
Authors: Emami Fard Nahal , Xiao Maria , Sehmi Roma
Published: September 2023

Over the past two decades, a growing body of evidence observations have shown group two innate lymphoid cells (ILC2) to be critical drivers of Type 2 (T2) inflammatory responses associated with allergic inflammatory conditions such as asthma. ILC2 release copious amounts of pro-inflammatory T2 cytokines – interleukin (IL)-4, IL-5, IL-9, and IL-13. This review provides a comprehensive overview of the newly discovered regulatory subtype of ILC2 described in murine and human mucosal tissue and blood. These KLRG1+ILC2 have the capacity to produce the anti-inflammatory cytokine, IL-10. Papers compiled in this review were based on query of PubMed and Google Scholar for articles published from 2000-2023 using keywords “IL-10” and “ILC2”. Studies with topical relevance to IL-10 production by ILC2 were included. ILC2 respond to microenvironmental cues including retinoic acid (RA), IL-2, IL-4, IL-10, IL-33, as well as neuropeptide mediators such as neuromedin-U (NMU), prompting a shift towards IL-10 and away from T2 cytokine production. In contrast, TGF-β attenuates IL-10 production by ILC2. Immune regulation provided by IL-10+ILC2s holds potential significance for management of T2 inflammatory conditions. The observation of context-specific cues which alter phenotype of ILC warrants examining characteristics of ILC subsets to determine the extent of plasticity or whether the current classification of ILCs requires refinement.
The Impact of Individual Heterogeneity on Household Asset Choice: An Empirical Study Based on China Family Panel Studies
Authors: Shen Luyi , Li Zeyang
Published: September 2023

In China’s evolving market economy, household asset diversification and refinement have raised concerns about asset selection and rationalization for financial market development. Our research investigates the impact of individual heterogeneity factors, such as the “Big Three” personality traits and cognitive abilities, on household asset allocation behaviors, expanding upon the traditional focus on risky financial assets and the “Big Five” personality traits. We utilize data from the 2018 China Family Panel Studies and employ logistic and hurdle models to examine the breadth of household asset holdings. We utilize two-part models to explore the depth of household asset holdings. Our findings reveal the impact of different personality traits and cognitive abilities on the depth and breadth of different household assets. This study offers a more comprehensive understanding of household asset selection by considering various asset types and individual heterogeneity factors.
Blockchain and Cryptocurrency: A Bibliometric Analysis
Authors: Jain Shaily , Sharma Chetan , Das Prasenjit , Shambhu Shankar , Chen Hsin-Yuan
Published: September 2023

Blockchain is a technology that collects data in a blockchain and allows transactions securely and transparently. It is used in many fields. Bibliometric publications examining detailed research trends in blockchain and cryptocurrency are still rare, but one bibliometric report did include research on the topic. The present work is filling in the void that eludes the study of research in the blockchain area. In the current work, we have included a wide range of blockchain and cryptocurrency research efforts to date. This study used the Scopus database to extract 2,045 articles from 2014 to 2021. The goal was to examine blockchain and cryptocurrency growth in volume, trend, global distribution, significant journals, pioneering authors, leading nations, and dominant sectors. This study highlights many aspects of worldwide blockchain and cryptocurrency research by researchers from all over the world. This research also studies how consensus decision-making and its processes are used. This study highlights many aspects of global blockchain and cryptocurrency research. This study also examines their use and consensus methods.
Can Sleep Apnea Be Detected from Human Pulse Waveform with Laplace Noise?
Authors: Kaneko Itaru , Phong Le Trieu , Emura Keita , Yuda Emi
Published: September 2023

Differential privacy is a powerful technique that protects the privacy of individuals in a dataset by adding controlled randomness. With the increasing developments in smart sensors, the use of various biometric database is expanding. If privacy protections coexist with advanced use of the biometric database, wider utilization is expected. One of the promising approaches is to apply differential privacy to biometric information, which is attracting attention in use cases such as Google. By adding Laplace noise to biometric information, differential privacy can be added. Our aim is to focus on peak to peak interval of electrocardiogram. It is useful bio-information because it is possible to know not only heart disease but also various physical conditions such as exercise amount, activity amount, fatigue, sleep based on it. In this study, we demonstrated that differential privacy can be applied to obtain the sleep apnea index from PPIs with Laplace noise. The observed correlations were 0.96 to 0.99 for the corresponding PPIs with Laplace noise.
Multi-Modal Emotion Classification in Virtual Reality Using Reinforced Self-Training
Authors: Liu Yi , Li Jianzhang , Cui Dewen , Sato-Shimokawara Eri
Published: September 2023

Affective computing focuses on recognizing emotions using a combination of psychology, computer science, and biomedical engineering. With virtual reality (VR) becoming more widely accessible, affective computing has become increasingly important for supporting social interactions on online virtual platforms. However, accurately estimating a person’s emotional state in VR is challenging because it differs from real-world conditions, such as the unavailability of facial expressions. This research proposes a self-training method that uses unlabeled data and a reinforcement learning approach to select and label data more accurately. Experiments on a dataset of dialogues of VR players show that the proposed method achieved an accuracy of over 80% on dominance and arousal labels and outperformed previous techniques in the few-shot classification of emotions based on physiological signals.
Osmanlı Devleti’nin Son Dönemlerinde Ayn Salîb Çeşmesi ve Vakfı [1848-1911]
Authors: AYHAN Recep
Published: September 2023

İnsanlığın en temel ihtiyaçlarından biri olan su, pek çok toplum için önemli bir yere sahiptir. İslâm dininin temizliğe ehemmiyet vermesi ve birçok ibadetin yerine getirilmesinin suya bağlı olması suyu Müslümanlar için de vazgeçilmez kılmıştır. Ayrıca İslâm dünyasında insanların su ihtiyacını karşılamak da önemli bir hayır hizmeti olarak kabul görmüştür. Bundan dolayı İslâm dünyasının birçok noktasında kuyu, sebil, çeşme gibi su tesisleri inşa edilmiştir. Vakıflarca desteklenen su tesislerinin önemli bir kısmı çeşmelerden oluşmaktaydı. Çeşme yapımı ve vakfı İslâm dünyasında önemli bir hayır olarak görülmüştür. Osmanlı Devleti’nde de devlet büyükleri, zengin eşraf ve maddi durumu iyi olanlar ülkenin birçok noktasında vakıflar kurup çeşmeler inşa ettirmiştir. Bu vakıf geleneği sayesinde Osmanlı Devleti’nin pek çok yerinde çeşmeler inşa edilmiş ve insanların su ihtiyacı bunlar aracılığıyla karşılanmıştır.

Osmanlı Dönemi’nde Siirt’te de insanların su ihtiyacını karşılayan çeşmeler bulunmaktaydı. Bunlardan biri de Ayn Salîb Çeşmesi’ydi. Yapım tarihi kesin olarak bilinmeyen bu çeşme, Osmanlı Dönemi’nde vakıf sistemi içerisinde yer almış ve varlığını günümüze kadar sürdürmüştür. Çalışmada Ayn Salîb Çeşmesi ile çeşmeye ait vakfın mülkleri, görevlileri ve harcamaları üzerinde durulmuştur. Bu çalışmanın amacı Ayn Salîb Çeşmesi ve vakfının 1848-1911 yılları arasındaki bilgilerini evkaf defteri, şer’iyye sicili, salnâme, hatırat, araştırma eser gibi çeşitli kaynaklar ışığında ortaya koymaktır.
Scientific substantiation of the routing of patients with atherosclerosis of the brachiocephalic arteries in the framework of the “Healthy Moscow” project.
Authors:   The Moscow Department of Health, Starshinin A. V. , Bezymyanny A. S. ,   Directorate for the coordination of the activities of medical organizations of the Moscow Department of Health, Grinin V. M. ,   I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Mingazova E. N. ,   N. A. Semashko National Research Institute of Public Health,   Kazan State Medical University
Published: September 2023

Modern stroke screening and treatment requires a systematic organization of medical care at all levels of the health care system in order to obtain results. In many countries there is a multilevel system of prevention, screening and treatment of stroke. Given the limited availability of large centers capable of providing complex multidisciplinary care to patients with stroke, it is necessary to develop and implement routing protocols for patients at risk of stroke, including patients with BCA pathology. Due to early detection and optimal routing, a high percentage of identified patients with BCA occlusion survive. An analysis of the experience of implementing screening for BCA pathologies as part of stroke prevention in the “Healthy Moscow” project showed that timely detected deviations with proper prevention can not only avoid the serious consequences of a stroke, but often prevent the development of the disease. In view of the determined global disparity in the accessibility of obtaining the necessary endovascular care by the population, the population screening program for BCA pathology within the framework of the “Healthy Moscow program is a significant contribution to the introduction of clinical management of cardiovascular care. The routing of patients with BCA pathology, implemented in, the “Healthy Moscow” project, is of undoubted practical value for the healthcare of Moscow and our country.
Application of the lean manufacturing model as an effective way to improve the activities of a dental clinic.
Authors:   St. Petersburg State Pediatric Medical University, Zatulkin V. A.
Published: September 2023

There is an increase in the need of the population, regardless of age, for dental care. At the same time, today there is a personnel shortage, insufficient staffing of the material and technical base of medical organizations providing dental care in outpatient settings. In this regard, it is necessary to search for new organizational technologies in the activities of these organizations to improve the availability and quality of medical care and meet the growing needs of patients. The purpose of the study: to evaluate the effectiveness of the developed model for the use of lean manufacturing technologies in dental practice. Materials and methods. In basic dental polyclinics, data on the timing of time spent by patients at the registry, while waiting for an appointment with a dentist–therapist, the time spent by a dentist–therapist in the treatment of medium caries of permanent teeth, taking into account the filling out of medical documentation before and after the use of lean manufacturing technologies, were analyzed. The assessment of the existing navigation in polyclinics, routing schemes for patients, methods of making an appointment was carried out by visualization method. In addition, the data of the survey of patients and employees of the dental clinic in the previously conducted study were analyzed. Results. After the application of lean manufacturing technologies, the time spent by the patient in the registry was reduced by 12–16 minutes. The total number of actions of the registrar decreased by 31.0%, and the distance traveled by 38.0–40.0%. The time of adding value at the reception of patients by a doctor increased by 20.0% (SP No. 1) and 24.3% (SP No. 2). The time of appointment of a dentisttherapist decreased by 33.8% in joint venture No. 1 and by 32.3% in joint venture No. 2. 72.7% of medical workers noted a positive effect in the activities of their polyclinics. The proportion of patients satisfied with the organization of medical care in dental clinics increased by 33.0%. On average, 88.5% of them noted positive changes in the registry, 73.0% – in the appointment of a dentist-therapist, 74.5% – in the new navigation, 75.0% – in the appointment. Findings. The use of lean manufacturing methods helped to reduce the time spent by patients at the reception desk, at the dentisttherapist’s appointment, increased the availability of an appointment, increased the satisfaction of both medical workers and patients. Thus, the use of the lean manufacturing technology implementation model has shown its effectiveness.
Methodological and methodical approaches to assessing the impact of global challenges on population health indicators and healthcare system.
Authors:   N. A. Semashko National Research Institute of Public Health, Orlov S. A. ,   National Medical Research Centre for Therapy and Preventive Medicine of the Ministry of Health of Russia, Aleksandrova O.Yu. ,   N. A. Semashko National Research Institute of Public Health, Gorenkov R. V. ,   N. A. Semashko National Research Institute of Public Health, Vasilieva T. P. ,   N. A. Semashko National Research Institute of Public Health, Zudin A. B. ,   N. A. Semashko National Research Institute of Public Health
Published: September 2023

The relevance is explained by the need to determine the list of indicators of public health and the functioning of the health system, which are influenced by biological, geopolitical and man-made challenges, considered as the transition of one of the determinants that determine the state of public health to an extreme state, and the rationale for their changes for timely organizational and managerial decisions. O b j e c t i v e : conduction an expert assessment and substantiate the impact of global biological, geopolitical and technogenic challenges on population health indicators and healthcare system. M a t e r i a l s a n d m e t h o d s . Based on the content analysis of domestic (n=14) and foreign publications (n=30), using expert assessment, a list of parameters was compiled that determine the impact of biological, geopolitical and technogenic challenges on population health indicators and healthcare system. R e s u l t s . The directions of changes in such health indicators of the population as primary and general morbidity according to the data of the appeal, mortality of the population in different age groups, life expectancy, physical development, disability and health groups, and such indicators of the structure of consumption of resources of the health system as access to medical care, the burden on medical workers, changes in financial costs are determined, as well as the risks of its sustainable functioning. D i s c u s s i o n . The theoretical substantiation of the vector of the impact of a particular type of global challenge to society on the state of indicators of key determinants of public health, allows for timely development of a set of preventive measures taking into account the models of response of determinants, improving approaches to their planning and organization both for the industry as a whole and at the level of a medical organization and the region.
Algorithm for the formation of social activity of a person during organ transplantation.
Authors:   Federal State Budgetary Educational Institution of Higher Education “Irkutsk State Medical University” of the Ministry of Health of the Russian Federation, Novozhilov A. V. , Kitsul I. S. ,   Irkutsk State Medical Academy of Postgraduate Education is a branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Published: September 2023

The article presents a description of the algorithm developed by the authors for the formation of social activity of a person during organ transplantation using the example of a kidney. The peculiarity of the functioning of the patient in the medical and social environment is shown, taking into account all the factors that arise in the terminal stages of diseases, leading to the need for organ transplantation. The mechanisms of the emergence of personal motivation of patients for transplantation are described.
Pemberdayaan Wakaf Produktif: Analisis Pengetahuan, Sikap, dan Praktik Takmir Masjid di Indonesia
Authors: Ibrahim Muhammad Hanif , Khoirunnisa Annes Nisrina , Mulyani Silvi Sri
Published: September 2023

Apart from being a place of worship, a mosque can become a center for thepeople's economy. One of the Islamic instruments that can be used is productivewaqf. Nadzir waqf who doubles as mosque takmir must have good knowledge ofmanaging waqf assets so that they can become a driving force for the economy insociety. Therefore, this study aims to empirically examine knowledge, attitudes, andpractices in empowering people by takmir mosques in Indonesia. The method usedin this study is quantitative by using the concept of Knowledge, Attitude, andPractice (KAP) theory using the Structural Equation Modeling (SEM) analysistechnique. Data collection in the field was carried out by distributingquestionnaires to 514 private mosque takmirs spread across 25 provinces in Indonesia. This research is expected to contribute to the development of waqf inIndonesia as an effort to increase the welfare of the people.
Performance of Indonesia's Sharia Capital Market for the 2022 Period
Authors: Maulida Atika Zahra , Risdiana Risda , Purnomo Agus
Published: September 2023

Islamic capital markets instruments such as stocks, mutual funds, and sukuk are tools to drive economic growth through the capital market sector. The financial sector's performance in the first semester remained stable in 2022. The indicator that is getting stronger in the JCI index is 5.02% or a year-to-date level of 69 11.58 as of June 2022. This article aims to find out the performance of the Indonesian Islamic capital market for the 2022 period. This research uses a qualitative method with a literature review approach regarding the development and growth of sharia capital market performance after Covid-19 pandemic. The result of the discussion for the population has an Islamic majority population, so the capital market industry is expected. To accommodate and collect contributions from Muslim citizens to be active in the stock market, especially the Islamic stock market, and a local investor in the Indonesian Sharia capital market. Realize naturally that investment products are developed following Islamic principles and teachings. The financial sector's performance in the first semester remained stable in 2022. The indicator getting more assertive in the JCI index is 5.02% or a year-to-date level of 69 11.58 at the end of June 2022.
Posicionamiento y calidad en Webs vinculadas a la psicología de la obesidad.
Authors: Arroyo-Fernández Andrea ,   Facultad de ciencias de la salud de Universidad Isabel I, Blanco-Fernández María Ascensión , Morata Verdugo María Piedad , Díaz María del Carmen , Lladó Jordan Gina ,   Departamento de Psicología de la Facultadde Ciencias Biomédicas de la Universidad Europea de Madrid,   Unidad de Obesidad, Hospital Virgen del Mar ( Sanitas).,   Instituto de investigación Sanitaria Valdecilla (IDIVAL),   Instituto de investigación Sanitaria Valdecilla (IDIVAL
Published: September 2023

Marco Teórico: La obesidad presenta una prevalencia en constante crecimiento enfatizando nece-sidad de actuar con responsabilidad y consciencia social. Internet ha transformado el papel del usuario dotándole de un papel activo en la gestión de su salud y destacando la importancia de acceder a un contenido de calidad. Objetivos: El objetivo principal fue estudiar la calidad y posicionamiento de las páginas Web vinculadas a la psicología de la obesidad y a subtemas asociados, tales como: hambre emocional, percepción corporal positiva e intervención psicológica. Método: Se realizaron búsquedas de recursos Web en Google Chrome® mediante palabras clave. Después de aplicar los criterios de in-clusión y exclusión, se incluyeron 99 recursos. Se analizó el posicionamiento de PageRank y la calidad de la información mediante DISCERN test. Resultados: El posicionamiento de los recursos fue medio, y la calidad moderada. La mayoría de recursos no contemplaban la psicología como abordaje terapéutico. Conclusiones: Los recursos analizados, indican que el usuario dispone de páginas moderadamente bien posicionadas con contenido de aceptable calidad pero insuficiente en cuanto al abordaje de la patología. Es urgente aumentar la visibilidad de la psicología en esta condición.
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke
Authors: He Xiao , Chen Jiadong , Zhong Yan , Cen Peili , Shen Li , Huang Fei , Wang Jing , Jin Chentao , Zhou Rui , Zhang Xiaohui , Wu Shuang , Tu Mengjiao , Qin Xiyi , Luo Xiaoyun , Zhou Yu , Peng Jieqiao , Zhou Youyou , Civelek A. , Tian Mei , Zhang Hong
Published: September 2023

Human neural progenitor cell transplantation shows great potential in stroke treatment by replacing lost cortical neurons and repairing damaged brain circuits. However, the commonly utilized human neural progenitors fail to yield a substantial proportion of diverse cortical neurons and require an extended period to achieve synaptic integration, thereby diminishing the optimal benefits of cell transplantation for stroke. Here, we generated forkhead box G1 (FOXG1)-positive forebrain progenitors from human inducible pluripotent stem cells, which can differentiate into various cortical neurons including upper- and deep-layer excitatory and inhibitory neurons, achieving early functional maturation simultaneously in vitro. Furthermore, these FOXG1 forebrain progenitor cells achieved robust cortical neuronal differentiation, rapid functional maturation and efficient synaptic integration after transplantation into the sensory cortex of stroke-injured adult rats. Notably, we have successfully utilized the non-invasive 18F-SynVesT-1 PET imaging technique to assess alterations in synapse count before and after transplantation therapy of FOXG1 progenitors in vivo for the first time. Moreover, the transplanted FOXG1 progenitors improved fine motor behavior and prevented the onset of chronic post-stroke seizures. These findings provide systematic and compelling evidence for the suitability of these FOXG1 progenitors for neuronal replacement in ischemic cortical stroke.
Single-Cell and Transcriptomic Analyses Reveal the Influence of Diabetes on Ovarian Cancer
Authors: Zhao Zhihao , Wang Qilin , Zhao Fang , Ma Junnan , Sui Xue , Choe Hyok Chol , Chen Peng , Li Siqi , Zhang Lin
Published: September 2023

Background:There has been a significant surge in the global prevalence of diabetes mellitus (DM), which increases the susceptibility of individuals to ovarian cancer (OC). However, the relationship between DM and OC remains largely unexplored. The objective of this study is to provide preliminary insights into the shared molecular regulatory mechanisms and potential biomarkers between DM and OC.
Methods:Multiple datasets from the GEO database were utilized for bioinformatics analysis. Single cell datasets GSE184880 and GSE165816 from the GEO database were analysed. Subsequently, immune cell infiltration analysis was performed on mRNA expression data from GSE40595 and GSE29142. The intersection of these datasets yielded a set of common genes associated with both OC and DM. Using these overlapping genes and Cytoscape, a protein‒protein interaction (PPI) network was constructed, and 10 core targets were selected. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were then conducted on these core targets. Additionally, advanced bioinformatics analyses, including transcription factor (TF)–genes interaction network analysis and microRNA (miRNA)–genes coregulation network analysis, were performed based on the core targets.
Results:Immune cell infiltration analysis of mRNA expression data revealed significant differences in mononuclear cell levels. By intersecting the single-cell datasets, a total of 119 targets related to mononuclear cells in both OC and DM were identified. PPI network analysis further identified 10 hub genesincludingHSP90AA1, HSPA8, SNRPD2, UBA52, SOD1, RPL13A, RPSA, ITGAM, PPP1CC, and PSMA5, as potential targets of OC and DM. Enrichment analysis indicated that these genes are primarily associated with neutrophil degranulation, GDP-dissociation inhibitor activity, and the IL-17 signaling pathway, suggesting their involvement in the regulation of the tumor microenvironment. Furthermore, the TF-gene and miRNA-gene regulatory networks were validated using NetworkAnalyst. The identified TFs included SREBF2, GATA2, and SRF, while the miRNAs included miR-320a, miR-378a-3p, and miR-26a-5p.
Conclusion: This study revealed the shared gene interaction network between OC and DM and predicted the TFs and miRNAs associated with core genes in monocytes. Our research findings contribute to identifying potential biological mechanisms underlying the relationship between OC and DM.
Comparison of intravenous nabuphine and dexmedetomidine in combination with lidocaine aerosol inhalation in awake direct laryngoscopy: a randomized, double-blind, placebo-controlled trial
Authors: Li Xingxing , Xie Cuiyu , Zhong Weiwei , Lu Yao , Li Yuanhai
Published: September 2023

Background: The airway should be thoroughly and accurately evaluated before anesthesia induction and endotracheal intubation. The awake direct laryngoscopy(ADL) is an important tool for assessing airway especially difficult airway, sometimes eliminates the need for fiberoptic intubation in some suspicious difficult airway cases. However, an optimal regimen has not been determined.
Aims: This study aimed to assess and compare the tolerance, satisfaction and safety of nalbuphine and dexmedetomidine combined with lidocaine for ADL.
Methods: In this double-blind, controlled study, prior to ADL, 60 patients scheduled for general anesthesia were randomly allocatedto receive 0.75μg/kg of Dex (Dex group, n = 20), 0.15 mg/kg of nalbuphine (Nal group, n = 20), or a placebo (control group, n = 20) intravenously for 10 minutes. At the same time, all study subjects received atomized lidocaine for 15 minutes.The primary outcome was patient tolerance as assessed by a 5-point ADL comfort score, while secondary outcomes included satisfaction, coughing, pain, nausea and vital signs.
Results: Patients undergoing ADL in the Nal group had higher tolerance scores than those in the control and Dex groups (P<0.01 andP<0.001, respectively) andhigher satisfaction (P<0.01 andP<0.001, respectively). Additionally, the Nal group had significantly fewer adverse events, such as nausea, coughing, and pain, than the control and Dex groups. The sedation score and peripheral oxygen and saturation was significantly higher in the Nal group than in the Dex group, with no difference between the Nal and control groups (P< 0.001, P =0.159, respectively).
Conclusions: Intravenous nabuphine in combination with lidocaine aerosol inhalation significantly improved patient tolerance and satisfaction while reducing nausea, coughing, pain, sedation and hypoxemia during ADL.
Trial registration: ChiCTR2200062116, 23/07/2022.