bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Dieldrin Selection for the Genetic Sexing of Aedes albopictus
Authors: Scussel Sarah , Gaudillat Benjamin , Esnault Jérémy , Lejarre Quentin , Duployer Marianne , Messaoudi Daouia , Mavingui Patrick , Tortosa Pablo , Cattel Julien
Published: June 2023

The mass production of mosquitoes at an industrial scale requires efficient sex separation, which can be achieved through mechanical, genetic or artificial intelligence means. Compared with others methods, the genetic sexing approach offers the advantage of limiting costs and space by removing females at larval stage. We recently developed a GSS in Aedes albopictus based on the sex linkage of the rdl gene to the M locus, conferring dieldrin resistance in males only. It has been previously reported that dieldrin ingested by larvae can be detected in adults and bioaccumulated in predators, raising the question of its use at a large-scale. In this context, we performed several experiments aiming at optimizing dieldrin selection by decreasing both dieldrin concentration and exposure time while maintaining a stable percentage of females averaging 1%. We showed that the previously used dieldrin exposure induced an important toxicity as it killed 60% of resistant males at larval stage. We could easily lower this toxicity by reducing the dose and/or the exposure time to recover nearly all resistant males. We then quantified the residues of dieldrin in resistant male adults and showed that dieldrin toxicity in larvae was positively correlated with dieldrin concentrations detected in adults. Interestingly, we showed that the use of reduced dieldrin exposure led to a dieldrin detection in adult males that was below the sensitivity threshold of the Gas Chromatography Mass Spectrometry detection method. Presented data show that dieldrin exposure can be adjusted to suppress toxicity in males while achieving efficient sexing and lowering the levels of dieldrin residues in adults to barely detectable levels.
Epidemiological Aspects of Tinea Capitis among Children Attending to Koranic Schools in Senegal (Thiés)
Authors: Sylla Khadime , Lelo Souleye , Diop Ibrahima , Fall Cheikh Binetou , Manga Isaac Akhenaton , Ndiaye Magatte , Sow Doudou , Tine Roger Clément , Faye Babacar
Published: June 2023

Introduction: Scalp ringworms or Tinea capitis are ubiquitous superficial fungal infections of the scalp and hair. They represent the most common dermatophytic in the world. They reach almost exclusively pre-pubescent children and mainly school-aged children. The objective of this study was to assess the prevalence of tinea capitis and its associated factors among residents of koranic schools located in the Thiès region of Senegal. Patients and Methods: A cross-sectional study was conducted from February 2019 to March 2020. School children living in Thiès region (Central part of Senegal) were included in this study. Socio-demographic, clinical and biological data were collected standard questionary. Samples collected were examined directly and developed on a medium of Sabouraud-Chloramphenicol and Sabouraud-Chloramphenicol-Actidione. A descriptive analysis was done with the Stata MP. Risk factors were assessed by multivariate survey logistic regression models. Significance level of the different tests was 0.05 two-sided. Results: A total of 110 children were included in this study. The mean age was 9 years and the population was predominantly male (96.4%). The average number of residents in Koranic schools was 112. The prevalence of scalp ringworms was 68.2% [(75/110) (95% CI: 53.6 – 85.5)]. The fungal species found were Trichophyton soudanense (93.4%), Microsporum audouinii (2.7%). Trichophyton mentagrophytes, and Trichophyton violaceum were found with each (1.3%). Parasitism was endothrix-like in 86.7%. Children over 10 years old were more affected (72.9%), OR =2,16, CI (0,48 - 9,69). The rate of positivity was higher in children with small plaques (72.7%). Children with irregular-edged plaques were most affected (76.5%), Prevalence was higher among children who slept at more than 3 per mattress (79.1%), OR=1.82 (95% CI: 1.08 – 3.04). Conclusion: These results showed that Tinea capitis are frequent in children living in community. Trichophyton soudanense is the main fungal specie identified. Better knowledge of the epidemiology of these diseases and improved living conditions for children in Koranic schools could help improve patient management.
Identification of Diagnostic Metabolic Signatures in Thyroid Tumors using Mass Spectrometry Imaging
Authors: Mao Xinxin , Huang Luojiao , Li Tiegang , Zeper Abliz , He Jiuming , Chen Jie
Published: June 2023

“Gray zone” category tumors in thyroid follicular tumors are difficult to diagnose, especially to distinguish between follicular thyroid adenoma (FTA) and follicular thyroid carcinoma (FTC). This study aimed to assess the diagnostic performance of metabolite enzymes using imaging mass spectrometry to distinguish FTA from FTC and determine the association between metabolite enzyme expression with thyroid follicular borderline tumor diagnosis. Air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFAIDESI-MSI) was used to develop a classification model for the characteristics of thyroid follicular tumors among 24 samples. We analyzed the expression of metabolic enzyme markers in an independent validation set of 133 cases and evaluated the potential biological behavior of 19 borderline thyroid lesions. Phospholipids and fatty acids (FAs) were more abundant in FTA than in FTC (P<0.001). The metabolic enzyme panel—including FA synthase and Ca2+-independent PLA2, which are closely associated with altered metabolic pathways—was further identified in follicular thyroid tumors. The marker combination showed optimal performance in the validation group (area under the receiver operating characteristic curve, sensitivity, and specificity: 73.6%, 82.1%, 60.6%, respectively). The diagnostic strategy suggested considering a putative role of AFAIDESI-MSI in routine clinical triage for strict follow-up, with low metabolic enzyme expression combined with diagnostic in patients with a thyroid follicular borderline tumor diagnosis.
Extreme Droughts and Their Relationship with the Interdecadal Pacific Oscillation over the Peruvian Altiplano Region during the Last 100 Years
Authors: Angulo Eleazar Chuchón , Pereira Filho Augusto Jose
Published: June 2023

Empirical Orthogonal Functions (EOF) analysis between the anomalies of Lake Titicaca water levels (WLs) and the Pacific Interdecadal Oscillation (IPO) reveals a correlation coefficient of 0.71 between the WLs and the principal component (PC1). These findings demonstrate the high accuracy of the IPO in representing the positive and negative phases of the water levels. By utilizing wavelet functions, we identified multi-decadal variability with periods ranging between 20 and 30 years. The statistical techniques employed indicate a relationship between IPO and ENSO; however, they operate on different timescales of climate variability. The IPO exhibits longer-term variability, typically spanning 20-30 years, while ENSO events occur on average every 2-7 years. Nevertheless, the IPO has the ability to modulate the strength and frequency of El Niño and La Niña events, and vice versa. During the positive phase of the IPO, there is a tendency for more frequent and intense El Niño events, accompanied by fewer La Niña events. This can be attributed to warmer sea surface temperatures in the central and eastern Pacific, which create favorable conditions for El Niño development. Conversely, during the negative phase of the IPO, there is a tendency for more frequent and intense La Niña events, with fewer occurrences of El Niño events, due to cooler sea surface temperatures in the central and eastern Pacific.
Pharmaceutical Strategies to Make Better Drugs for Nonalcoholic Fatty Liver Disease Therapy
Authors: Amatya Reeju , Lee Donghee , Min Kyoung Ah , Shin Meong Cheol
Published: June 2023

Nonalcoholic fatty liver disease (NAFLD) has become globally prevalent and is the leading cause of chronic liver disease. Although NAFLD is reversible in the early stage without medical intervention, the condition could be sequentially worsened to nonalcoholic steatohepatitis (NASH) and, in the end, cirrhosis and hepatic cancer. The progression of NAFLD is related to various factors such as genetics, pre-disposed metabolic disorders, and immunologic factors. Because of the complexity of the disease, the treatment options are very limited, and, unfortunately, there is yet no clinically available drug. Thankfully, to date, there have been accumulating research efforts and, as a result, different classes of potent drug candidates have been discovered. Besides, there have also been various attempts to explore pharmaceutical strategies to make the drug candidates to be better drugs. In this review, we provided a brief overview of the drug candidates that have undergone clinical trials. In the latter part, the strategies for developing better drugs are discussed.
Transition-Metals Doped TiO2 Nanoparticles Supported on Zeolite Y with Photocatalytic Properties
Authors: Petcu Gabriela , Papa Florica , Atkinson Irina , Băran Adriana , Apostol Nicoleta G. , Petrescu Simona Viorica , Richaudeau Lionel , Blin Jean-Luc , Parvulescu Viorica
Published: June 2023

Zeolite Y with microporous and hierarchical structure containing Ti–Ni and Ti–Co oxides were obtained as active photocatalysts. Different Ti amounts (5, 10% TiO2) were supported, followed by loading of Ni or Co oxides (5 %). The X-ray diffraction evidenced the presence of TiO2 as anatase. N2 adsorption-desorption results showed type IV isotherms, for hierarchical zeolite Y samples, and a combination of type IV and I isotherms, for zeolite Y samples. UV–Vis diffuse reflectance spectra showed shift of absorption band to visible with increasing of Ti loading and especially after Co and Ni addition. A significant effect of the support was evidenced for Ti and interaction with Co/Ni species. The zeolite Y support stabilizes Ti in the 4+ oxidation state while hierarchical zeolite Y support favored the formation of Ti 3+ species and oxidation of Co and especially of Ni to 3+. Photocatalytic activity, under UV and visible light, was evaluated in degradation of amoxicillin, used as a model test. The photocatalytic mechanism was investigated using ethanol, p-benzoquinone and KI as ·OH, ·O2- radicals and hole (h+) scavengers. The best results were obtained for the immobilized Ni-Ti species on hierarchical zeolite Y support.
Mapping Aquifer Water Quality in the Western Fringes of Beni-Suef Governorate for Sustainable Agriculture
Authors: Elsharkawy Mohamed
Published: June 2023

Aquifer water is the key staple to develop successful sustainable agricultural activity in newly reclaimed areas in Egypt. Monitoring irrigation water quality is necessary for a proper planning of this exhaustible resources. This work aims to evaluate the groundwater quality in the western newly reclaimed areas of Beni-Suef governorate. Fifty aquifer water sample were collected from wells scattered in the arid western Beni-Suef fringes during May of 2022. Water chemical analyses were conducted to estimate the parameters of Irrigation Water Quality Index (IWQI) namely the Electrical Conductivity (EC), Sodium (Na+), Chloride (Cl-), Bicarbonate (HCO3-) and the Adjusted percentage of Absorbed Sodium (SARo). The Inverse Distance Weighted (IDW) technique used to map the spatial distribution of aquifer water chemical characteristics and IWQI. The results showed that EC values were high in the south of the study area and decreased at its north and east borders. The results showed that the average of dissolved cations and anions were 236.4, 102, 77.5, 106.2, 309.6, 148.1 and 113 meq/l for Ca2+, Mg2+, Na+, K+, SO42-, HCO3-, and Cl-, respectively. Regarding to IWQI, its' values ranged from 28 to 81. Two-thirds of the study area classified as having moderate limitations for sustainable irrigation purposes. Furthermore, one-thirds of the area classified as having high restrictions.
On the Sub Convexlike Optimization Problems
Authors: Zeng Renying
Published: June 2023

In this paper, we prove that the sub convexlikeness introduced by V. Jeyakumar [1], and the subconvexlikeness defined in V. Jeyakumar [2] are equivalent in loccallly convex topological spaces. And then, we work with set-valued vector optimization problems and obtain some vector saddle-point theorems and vector Lagrangian theorems.
Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H Variant
Authors: Velázquez-Soto Henry , Groman-Lupa Sergio , Cruz-Aguilar Marisa , Salazar Alberto , Zenteno Juan C. , Martinez Maria C. Jimenez
Published: June 2023

Age-related macular degeneration (AMD) is a complex, progressive degenerative retinal disease. Retinal pigment epithelial (RPE) cells play an important role in the immune defense of the eye, and their dysfunction leads to the progressive irreversible degeneration of photoreceptors. Genetic factors, chronic inflammation, and oxidative stress have been implicated in AMD pathogenesis. Oxidative stress causes RPE injury, resulting in a chronic inflammatory response and cell death. The Y402H polymorphism in the complement factor H (CFH) protein is an important risk factor for AMD. However, the functional significance of CFH Y402H polymorphism remains unclear. In the present study, we investigated the role of CFH in the proinflammatory response using an in vitro model of oxidative stress in the RPE with the at-risk CFH Y402H variant. : ARPE-19 cells with the at-risk CFH Y402H variant were highly susceptible to damage caused by oxidative stress, with increased levels of inflammatory mediators and pro-apoptotic factors that lead to cell death. Pretreatment of ARPE-19 cell cultures with exogenous CFH prior to the induction of oxidative stress prevented damage and cell death. This protective affect may be related to the negative regulation of pro-inflammatory cytokines. CFH contributes to cell homeostasis and is required to modulate the pro-inflammatory cytokine response under oxidative stress in the ARPE-19 cells with the at-risk CFH Y402H variant.
APPLICATION OF THE INTEGRATION METHOD TO OBTAIN A COMPLEX INDICATOR OF LABOR SAFETY
Authors: Cherniak Olena , Sorocolat Nataliia , Fatieieva Lina , Bahaiev Ihor , Trishch Yuliia
Published: June 2023

The current state of quantitative assessment of the quality of qualimetry objects of different nature, which have different quality indicators and different measurement scales, is considered. Existing studies and publications with quantitative assessment related to occupational safety are analyzed. Harmful and dangerous factors that affect human health and performance have their own indicators and scales of different assessments. At present, there is no single approach to assessing these indicators, and a large number of qualimetric methods require in-depth scientific research on their optimality and effectiveness. The analysis proves the relevance of the topic and identifies the need to develop a methodology for obtaining a comprehensive assessment of labor safety that will be suitable for assessing working conditions at any production facility. To obtain a comprehensive indicator of occupational safety, it is proposed to determine the assessment for each harmful production factor, and then to determine a single assessment, taking into account all the characteristics. To determine the complex indicator of a harmful production factor, it is proposed to apply the integration method. The trapezoidal method is one of the methods of numerical integration. It allows calculating certain integrals with a predetermined degree of accuracy. A step-by-step algorithm for determining a complex labor safety indicator using the trapezoidal integration method is proposed. An approbation of the methodology for determining a comprehensive indicator of labor safety is proposed. The harmful factors at work are identified, the actual indicators are obtained and their estimates are determined on a dimensionless scale. A time series of changes in the indicators of harmful factors over time is graphically constructed. A comprehensive indicator of labor safety at work has been determined, which makes it possible to make managerial decisions on further actions to improve working conditions and improve the labor safety management system. The proposed methodology can be considered universal, since it can be applied to any premises and enterprise.
DIGITAL TWIN VALUE IN INTELLIGENT BUILDING DEVELOPMENT
Authors: Zakharchenko Anastasiya , Stepanets Oleksandr
Published: June 2023

The aim of the research. This article discusses the use of the Digital Twin in automation and its impact on the resulting solution. The research aims to illuminate the Digital Twin concept explanation and systematise the knowledge base and fulfill information gaps. Research results. The paper overviews the history of the concept and determines the main phases of Digital Twin development. The significant attention was paid to the classification issue to show the huge variation depending on Digital Twin‘s purpose, lifecycle phase, the scale of the physical twins and data amount in order to explain the twin‘s relation and the hierarchy of complex system. The defined capabilities and values of the concept identify the possible use cases and explain the potential benefits of Digital Twin implementation. Also, this paper takes a look at the use of Digital Twin in the area of building automation. This concept potentially may act as the integration platform for building management systems (BMS) and building information modelling (BIM) technologies with IoT solutions. The discussion of Digital Twin implementation for the building automation complex is presented. We conclude that the Digital Twin can integrate human factor to the control system by using the indexes of climate satisfaction, the feedback functionality and human-machine interfaces. As a result, the improvement of system efficiency depends on the coordination and orchestration of equipment operating mode. Conclusion. The Digital Twin has a high potential for energy efficiency improvements, as it considers many factors, integrates a huge amount of data and continuously improves themselves with real-world data.
BIOMETRIC AUTHENTICATION UTILIZING CONVOLUTIONAL NEURAL NETWORKS
Authors: Datsenko Serhii , Kuchuk Heorhii
Published: June 2023

Relevance. Cryptographic algorithms and protocols are important tools in modern cybersecurity. They are used in various applications, from simple software for encrypting computer information to complex information and telecommunications systems that implement various electronic trust services. Developing complete biometric cryptographic systems will allow using personal biometric data as a unique secret parameter instead of needing to remember cryptographic keys or using additional authentication devices. The object of research the process of generating cryptographic keys from biometric images of a person's face with the implementation of fuzzy extractors. The subject of the research is the means and methods of building a neural network using modern technologies. The purpose of this paper to study new methods for generating cryptographic keys from biometric images using convolutional neural networks and histogram of oriented gradients. Research results. The proposed technology allows for the implementation of a new cryptographic mechanism - a technology for generating reliable cryptographic passwords from biometric images for further use as attributes for access to secure systems, as well as a source of keys for existing cryptographic algorithms.
ANTIMICROBIAL POTENTIAL OF ALKALOIDS AND FLAVONOIDS EXTRACTED FROM TAMARIX APHYLLA LEAVES AGAINST COMMON HUMAN PATHOGENIC BACTERIA
Authors: Adnan Muhammad , Tariq Akash , Bibi Roqaia , AbdElsalam Naser M , Rehman Hazir , Murad Waheed , Ahmad Shabir , Israr Muhammad , Sabahat Sajjal , Ullah Riaz , Akber Asma , Din Jamal ud , Aziz Muhammad Abdul
Published: June 2023

Background: Alkaloids and flavonoids are secondary metabolites extracted from different medicinal plants. Tamarix aphylla a traditionally

valuable medicinal plant; was used for the extraction of alkaloids and flavonoids in order to evaluate their antibacterial activity.

Methodology: The leaves of the plant were collected from district Kohat, Pakistan, and their alkaloids and flavonoids were extracted with ethanol

and methanol, respectively. Four bacteria i.e. Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli, Salmonella typhi and

Pseudomonas aeruginosa) were selected for the biological screening of these phyto-constituents.

Results: The concentration of alkaloids was found to be more in the leaves of Tamarix aphylla than flavonoids. The extracted phytochemicals

showed varied inhibition zones against tested bacterial isolates. Alkaloids showed highest inhibitory activity against Staphylococcus aureus

(14±0.6 mm) followed by Pseudomonas aeruginosa (13±0.7 mm). Conversely, flavonoids showed the highest inhibitory affect against

Salmonella typhi (17±0.7 mm) followed by Staphylococcus aureus (14±0.7 mm). However, both extracts showed the lowest inhibitory effects

against Escherichia coli.

Conclusions: It was concluded that the alkaloids and flavonoids from Tamarix aphylla leaves have antimicrobial potential against common

human bacterial pathogens. However, flavonoids were found to be more active phytochemical against tested bacterial strains as compared to

alkaloids.
HYDROXYMETHYL FURFURAL IN CHINESE HERBAL MEDICINES: ITS FORMATION, PRESENCE, METABOLISM, BIOACTIVITIES AND IMPLICATIONS
Authors: Gao Hui-feng , Wen Xue-sen , Xian Cory J.
Published: June 2023

Hydroxymethyl furfural (HMF) is one of important intermediates formed in Maillard reaction and caramelization. It was found that HMF existed in many Chinese herbal medicines (CHMs) and accumulated during CHM processing. In recent years, increasing attention has been paid to its safety and actions in CHMs, which has led to many reports about different aspects of HMF. In this paper, previous and recent studies on HMF formation, its presence in CHMs, its metabolism and bioactivities, together with its implications for CHMs were summarized, with the purpose of contributing to a better understanding of CHMs.
ANTIMICROBIAL, ANTIOXIDANT AND ANTICANCER ACTIVITIES OF STRYCHNOS LUCIDA R. BR.
Authors: Sarmento Nevio da Costa , Worachartcheewan Apilak , Pingaew Ratchanok , Prachayasittikul Supaluk , Ruchirawat Somsak , Prachayasittikul Virapong
Published: June 2023

Backgroud: Strychnos lucida R. Br. (Loganiaceae), a well-known indigenous medicine in Timor Leste, has been used for the treatment of ailments

such as malaria, diarrhoea, fever, hypertension, cancer, diabetes mellitus and skin infections. Its pharmacological activity has never been reported.

The aim of this study was to determine the biological activities of S. lucida, including antimicrobial, antioxidant and anticancer activities.

Materials and methods: The stem, stem bark, twig and leaves of S. lucida were extracted by non-polar (hexane) and polar (ethyl acetate and

methanol) solvents. Antimicrobial activity of the plant extracts against 29 microorganisms was evaluated using the agar dilution method and

antioxidant properties were determined using DPPH and SOD assays. Anticancer activity was investigated against HepG2, HuCCA-1, A549 and

MOLT-3 cell lines using the MTT and XTT assays.

Results: It was found that the hexane and ethyl acetate extracts of S. lucida selectively inhibited the growth of Gram positive bacteria (Bacillus subtilis

ATCC 6633, Bacillus cereus and Streptococcus pyogenes) with MICs range of 32-128 g/mL. Antioxidant activities, radical and superoxide

scavenging properties, were observed for ethyl acetate and methanol extracts of S. lucida. Particularly, the ethyl acetate extracts selectively showed

inhibitory activity against MOLT-3 cells. Notably, the plant extracts showed the relationship between antimicrobial, antioxidant and anticancer

activities.

Conclusion: The findings support the medicinal usage of S. lucida.
ANTIFUNGAL ACTIVITY OF METHANOLIC ROOT EXTRACT OF WITHANIA SOMMNIFERA AGAINST FUSARIUM OXYSPORUM F. SP. CEPAE
Authors: Javaid Arshad , Akhtar Roma
Published: June 2023

Background: Basal rot of onion (Allium cepa L.) caused by Fusarium oxysporum f. sp. cepae is a common soil-borne disease that causes significant yield losses. Generally, synthetic fungicides are used to combat the menace which cause environmental pollution. The present study was carried out to assess the antifungal activity of Withania somnifera (L.) Dunal, a Solanaceous medicinal plant, against the pathogen of this disease.

Materials and Methods: Different concentrations (from 0.5 to 4%) of methanolic extract of root, stem and fruit of the test plant species were prepared and their bioactivity was assessed against the target fungal pathogen. Methanolic extract of root was further fractionated with n-hexane, chloroform, ethyl acetate and n-butanol. Different concentrations of these extracts viz. 200, 100… 3.125 mg mL-1 were prepared and assessed for their antifungal activities.

Results: Methanolic root extract exhibited the best antifungal activity causing up to 93% decrease in biomass of the fungal pathogen. n-hexane, chloroform and ethyl acetate fractions of methanolic root extract exhibited pronounced antifungal activity resulting in 46–79%, 40–73% and 35–76% reduction in fungal biomass, respectively.

Conclusion: The present study concludes that root extract of W. somnifera possesses potent antifungal constituents which can be used for the control of F. oxysporum f. sp. cepae.
EFFECT OF QIANLIE XIAOZHENG TANG, A CHINESE HERBAL DECOCTION, ON CASTRATION RESISTANT PROSTATE CANCER: A PILOT STUDY
Authors: Pang Ran , Gao Xiaosong , Lu Jianxin , Zhang Yaqiang
Published: June 2023

Background: To examine the effect of Qianlie Xiaozheng Tang (QLXZT), a Chinese herbal decoction, on treating castration resistant prostate cancer

(CRPC).

Materials and Methods: A total of 70 men with CRPC were recruited and randomly allocated into treatment groups (treated with QLXZT and

conventional therapy) or control group (treated with conventional therapy) for 12 weeks treatment. Primary endpoint was serum prostate specific

antigen (PSA) concentration. Secondary endpoints included patients' quality of life measured by Functional Assessment of Cancer Therapy-Prostate

questionnaire, and prostate cancer-specific anxiety assessed by Memorial Anxiety Scale for Prostate Cancer.

Results: After a 12-week treatment, the PSA level in control group rose remarkably from 45.3 ± 17.0 to 76.0 ± 56.7 ng/ml (P=0.0015). By contrast,

the PSA level in treatment group did not increase significantly (P>0.05). The scores of Functional Assessment of Cancer Therapy-Prostate in each

domain changed significantly (P
17. Asır İstanbul’unda Bir Tekke Mahfili: Arzî Mehmet Dede’nin Şeyhliği Döneminde Galata Mevlevîhanesi
Authors: İLHAN Bilge
Published: June 2023

Mevlevîhaneler, edebiyat, musiki, hat gibi sanatların öğretildiği, bu dallara ait eserlerin üretildiği yerler olmaları yönüyle, Türk kültürünün şekillenmesinde rol alan mekânlardır. Özellikle 16. yüzyıldan itibaren gittikçe kentlileşen Mevlevîlik, genellikle yüksek kültür çevrelerinde gelişmiş; bu durum tarikatın yönetici sınıfla yoğun bir temas sağlamasına imkân tanımıştır. Mevlevîhanelerin, hem tarikatın Mevlânâ’dan itibaren sanatla iç içe olan mekânlar olması hem de yönetici sınıf tarafından desteklenmeleri bu mekânların, birer mahfil ve zamanla edebî muhitler oluşturarak şairlerin yetişmesinde rol almasını sağlamıştır. Çalışmada, Osmanlı başkentinin ilk Mevlevî âsitânesi olan Galata Mevlevîhanesi’nde, Arzî Mehmet Dede (ö.1074/1664)’nin şeyhliği dönemindeki edebî hayat incelenmiştir. Arzî Dede’nin şeyh olmadan önce, dergâh içerisinde edebiyat eğitimi alması; bu eğitimin, onun postnişin olmasındaki etkisi ve şeyhi Âdem Dede (ö.1063/1652) gibi dervişlerin edebî eğitimine katkısı, çalışmada özellikle bu döneme odaklanılmasını sağlamıştır. Çalışmada, Arzî Dede’nin Galata Mevlevîhanesi şeyhliği dönemi örnekliğinde; tarikat, edebiyat ve siyaset arasındaki ilişkinin, dergâh çevresindeki edebî mahfile nasıl etki ettiğinin ortaya koyulması amaçlanmıştır. 17. asır İstanbul’unda, edebiyat mahfili olan Galata Mevlevîhanesi’nde; Arzî Dede’nin, şeyhi Âdem Dede tarafından edebî yönden de yetiştirilmesinin, onun şeyh olma sürecine katkısı ortaya koyulmuştur. Ayrıca, Arzî Dede’nin himâyesinde dergâhta yetişen, dergâha devam eden şairlerin kimler olduğu, şiirlerin şeyhe sunumu ve dergâhın edebî hayatının şekillenmesindeki dinamikler çalışmada ele alınmıştır.
Intellectual Property Law Aspects of Environmental Protection and Sustainable Development: Where Is the Line Between Public and Private Interests?
Authors: Savcic Sanja
Published: June 2023

Protection of the environment is regulated by numerous laws and bylaws, within legal areas. As regards regulations of an imperative nature, there is no doubt that these provisions represent the public interest and responsibility of the state to preserve and improve the environment. The paper examines the potential of private law rights to contribute to environmental protection and improvement, because the action of entities depends on the choice of whether to act or not in certain circumstances. To illustrate a possible contribution of private law in environmental protection matters, patent and indications of geographical origin have attracted attention. While trying to determine a particular connection between rights and environmental matters, it has become clear that significant improvement of environmental protection can be provided in a circular flow through different areas of law. Protecting and supporting private law rights is not detached from guarding the public interest. An examination of patent law potential should demonstrate that cooperation between scientific research institutions and industry is of primary concern in modern society. In practice, a number of issues obstruct successful cooperation; however, this is an opportunity for the state to encourage collaboration. A similar approach should be suggested in relation to indications of geographical origin. State and local governments should encourage recognition of indicators of geographical origin, attracted to localities of high environmental quality.
Waste management and its possible development in the Slovak Republic
Authors: Maslen Michal
Published: June 2023

This paper analyses the climate impacts of the individual waste management activities expressed in the waste management hierarchy. The author seeks to include the mentioned impacts in the Slovak reality of waste management. Moreover, this paper includes foreign approaches to municipal waste management and the analysis of the extent of merits and demerits of waste-to-energy plants. Herein, the author seeks to assess the current possibilities of heat and electricity production from municipal waste. According to the waste management hierarchy, the waste to-energy approach is better and more suitable than waste landfilling (waste disposal). However, it must not collide with higher methods of waste management hierarchy. The mentioned principle should be respected when performing the waste-to-energy approach; however, some types of materials are not suitable for higher methods of the waste management hierarchy, such as personal protective equipment, including facemasks, protective clothing, helmets, goggles, or other garments, or equipment predominantly designed to protect the wearer9s body from infection by COVID-19. Per my perspective, these waste materials are highly suitable for waste-to-energy production because of their depreciation caused by the possible infection. Therefore, the methods of prevention, re-use, or recycling are not applicable to them. However, these objects have the potential to serve as sources of energy. In my knowledge, Slovak legislation has not responded in a specific legislative way that would state how to manage the aforementioned objects. Thus, in general, this paper elucidates the possible development of waste-to-energy plants in the Slovak Republic and also describes the author9s approach to the opportunities of the landfill backdown in the Slovak legal environment.
Hybrid Vehicles: An Analysis of Efficiency and Environmental Impact
Authors: Mukhamadiev Gayrat
Published: June 2023

This study examines the advantages and disadvantages of hybrid vehicles, focusing on their capacity to mitigate harmful emissions and improve fuel efficiency. It discusses the operating principles of internal combustion engines, electric motors, inverters, and batteries used in hybrid vehicles, illustrating their key roles in improving environmental sustainability. The research analyses three power device interconnection schemes: series, mixed, and parallel, exemplified by Chevrolet Volt and Honda models respectively. The results indicate that despite high upfront costs, hybrid vehicles significantly reduce harmful emissions and fuel consumption, particularly in urban driving conditions. Furthermore, their positive environmental impact and fuel economy potentially position hybrid vehicles as future market dominants. The study highlights the importance of hybrid vehicles in mitigating climate change and calls for continued advancements and global investment in this promising technology.Highlights:

Hybrid vehicles significantly reduce harmful emissions and improve fuel efficiency, particularly beneficial in urban environments.

Three power device interconnection schemes (series, mixed, and parallel) dictate the operational characteristics and efficiency of hybrid vehicles.

Despite the initial high investment, the long-term benefits of hybrid vehicles such as lower fuel consumption and environmental impact could make them a dominant player in the future automotive market.

Keywords: Hybrid Vehicles, Internal Combustion Engine, Electric Motor, Emission Reduction, Fuel Efficiency.
The Strategy of Turn-Taking in Pygmalion by George Bernard Shaw
Authors: Abbar Najlaa Hayyawi
Published: June 2023

This scientific article examines the turn-taking system and adjacency pairs in George Bernard Shaw's play "Pygmalion" to gain insights into the rules and characteristics of conversational interaction. The study aims to investigate the adoption of turn-taking rules and components in the selected texts, analyze the structure of the texts, and explore the tactics employed in written texts related to turn-taking rules, elements, preference systems, and adjacency pairs. Through a meticulous analysis of the selected texts, it is revealed that the data adheres to the criteria of the turn-taking system and includes both adjacency pairs and insertion sequences. The findings contribute to the understanding of the turn-taking theory and its application in analyzing discourse. The implications of this research highlight the importance of understanding the systematic nature of turn-taking in facilitating successful exchanges in conversations and provide valuable insights for conversation analysts, linguists, and professionals in the field of discourse analysis.

Highlights:

Analysis of turn-taking system and adjacency pairs in "Pygmalion" play.

Investigation of turn-taking rules, components, and tactics employed in written texts.

Findings demonstrate adherence to turn-taking criteria and presence of adjacency pairs and insertion sequences.

Keywords: Turn-Taking System, Adjacency Pairs, Conversation Analysis, Discourse Analysis, Pygmalion
Prevalência da esclerose múltipla em pacientes tratados com medicamentos modificadores do curso da doença utilizando dados do Sistema Único de Saúde brasileiro
Authors: Bianco Juares , Damasceno Alfredo , Becker Jefferson , Casarin Fabiana , Carlos Nayara , Martins Tamiê , Yazawa Priscila
Published: June 2023

Objetivo: Compreender o cenário da esclerose múltipla (EM) em relação aos aspectos epidemiológicos, diagnósticos, progressão, tratamento e comorbidades no sistema público brasileiro. Métodos: Trata-se de um estudo retrospectivo e observacional utilizando os sistemas de dados do Departamento de Informática do Sistema Único de Saúde (DataSUS). Os dados utilizados foram obtidos por meio da base de dados do Sistema Ambulatorial/Sistema de Procedimentos de Alta Complexidade (SIA/SUS). Nessa base, o vínculo de registros foi por meio do Cadastro Nacional de Saúde (CNS). Para a quantificação de dados epidemiológicos, foram coletados os dados do Código de Endereçamento Postal (CEP), sexo e data de nascimento, além das bases de geolocalização dos pacientes. Considerou-se como desfecho primário a descrição epidemiológica da população de pacientes em uso ou que usaram MMCD para o tratamento da EM. Como desfecho secundário, consideraram-se as características dos pacientes (gênero, idade, idade ao diagnóstico e comorbidades). Resultados: Foram incluídos na análise 45.011 pacientes. Identificou-se predominância de pacientes do gênero feminino (72,9%) e com idade entre 31 e 60 anos (61,23%) diagnosticados com CID G35 no primeiro registro. A taxa de incidência de pacientes com EM foi maior (2,7 pacientes/100 mil habitantes) na região Sudeste, seguida pela região Sul (2,2 pacientes/100 mil). A prevalência na região Sul teve a maior taxa (18 pacientes/100 mil), seguida pelo Sudeste (16,7 pacientes/100 mil). As betainterferonas e o acetato de glatirâmer foram os medicamentos mais utilizados no primeiro tratamento. O acetato de glatirâmer foi o mais utilizado para o segundo tratamento no período de 2011 até 2017. Em 2018, os MMCD mais utilizados como segundo tratamento foram fingolimode e natalizumabe. A partir de 2019, fingolimode, fumarato de dimetila e natalizumabe foram os medicamentos mais utilizados como segundo tratamento, permanecendo nessa ordem até 2021. Para o terceiro tratamento, o natalizumabe foi o medicamento mais utilizado até 2017. Após esse período, o fingolimode passou a ser mais usado. Desde 2019, com o acesso ao fumarato de dimetila, os medicamentos mais prescritos foram, em ordem decrescente, fingolimode, natalizumabe e fumarato de dimetila. Conclusão: Estabelecer uma análise epidemiológica dos pacientes que usam MMCD para o tratamento da EM no Brasil, além do padrão de tratamento, são dados essenciais para a promoção do tratamento da EM de forma adequada, bem como para a implementação de políticas públicas locais, regionais e nacionais.
Late Paleozoic–Cenozoic Tectonothermal Evolution of Transbaikalia: Thermochronology of the Angara–Vitim Granitoid Batholith
Authors: Travin A.V. , Buslov M.M. , Bishaev Yu.A. , Tsygankov A.A. , Mikheev E.I.
Published: June 2023

—The tectonothermal evolution of Transbaikalia is reconstructed using U/Pb, 40Ar/39Ar, and apatite fission track thermo-chronology of samples from the Late Paleozoic Angara–Vitim granitoid batholith (AVB). Successive closure of the zircon and amphibole isotope systems provides evidence that the AVB rocks cooled down rapidly soon after crystallization and 7–4 km of rocks were denuded subsequently during an extensive late Paleozoic orogeny in southern Siberia. The isotopic system of feldspar closed in the Middle Jurassic–Early Cretaceous (170–140 Ma) after a period of tectonic stability and slow closure of the biotite isotopic system in the early Permian–Middle Jurassic (295–170 Ma). The 170–140 Ma span was the time when the Mongol–Okhotsk orogen began its evolution, and the orogeny caused denudation of ~3 km of rocks. Denudation was slow in the Paleogene–Miocene (60–5 Ma) but accelerated over the past 5 million years (a ~3–2 km thick layer) during rapid cooling of rocks and activity under a far-field effect of the India–Eurasia collision.
Predictors and consequences of subclinical renal impairment in patients with vascular disease
Authors: Somkereki Cristina , Nicoară Tunde Renata , Oprica Mădălina , Demian Liliana , Scridon Alina
Published: June 2023

Aim: Estimated glomerular filtration rate (eGFR) is the most widely used biomarker of kidney function. More sensitive biomarkers may be required to detect additional predictors and consequences of kidney injury. We aimed to identify predictors and consequences of subclinical renal impairment, as reflected by the levels of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C.
Methods: A cross-sectional study was performed in 71 patients with vascular disease. Demographic and anthropometric data, medical history, and ongoing drug therapy were recorded. Blood count, haemoglobin, plasma potassium, glucose, lipids, proteins, serum creatinine, uric acid, NGAL and cystatin C levels, and eGFR were evaluated. Potential predictors and consequences of increased NGAL and cystatin C levels were assessed.
Results: Hypertension, diabetes, and diuretic therapy were the only independent predictors of decreased eGFR (all p<0.05). Meanwhile, increased white blood cell count and diuretic usage were independently associated with higher NGAL and cystatin C levels, respectively, and increased uric acid levels were independently associated with higher levels of both biomarkers of kidney injury (all p<0.05). At their turn, increased NGAL and cystatin C were independently associated with lower albumin and HDL-cholesterol levels, and increased cystatin C levels were also associated with higher serum potassium (all p<0.05).
Conclusion: eGFR was associated with widely known risk factors for impaired renal function. Meanwhile, NGAL and cystatin C identified more subtle subclinical kidney injury-related hematologic and biochemical changes. These data reinforce the role of NGAL and cystatin C as biomarkers of subclinical kidney injury and predictors of subclinical kidney injury-related abnormalities.
An adaptive ml model for covid-19 diagnosis in a smart hospital environment
Authors: Duodu Nana Yaw , Benuwa Ben-Bright , Techie-Menson Henry
Published: June 2023

The Covid-19 pandemic has since 2019 caused worldwide socio-economic unrest, fear, and panic among all individuals, nations, races, and continents thereby forcing governments to introduce This necessitated the integration of predictive models into the healthcare support system for effective diagnostic and prediction of Covid-19. The need for modeling existing models to provide satisfactory models, give a clear understanding of the existing model contribution and further improve these models has become significantly necessary since the lack of confidence in predictive health systems would slow the early diagnostics and detection of Covid-19 in the smart health environment and in the world at large. This study is an adaptive study to experiment with existing models to ascertain and confirm the effectiveness of the model and further attempt to improve the performance of existing models to give healthcare system designers the edge to build and increase the effectiveness of Covid-19 predictive systems in a smart hospital environment. The study model 3 separate Arthurs conducted to produce a real-time intelligent Covid-19 predictive model using dataset from the Kaggle dataset repository, which can be implemented in smart hospitals to help eliminate physical contact treatment by healthcare professionals, prevent long queues which lead to long waiting at the healthcare facility. The experimental result confirms the efficacy of the models proposed by the authors and a further moderation to implement the stacking ensemble classifier techniques outperformed the modeling studies by producing an accuracy result of 96.00% and scoring an error rate of 0.040 representing 4%, having 1% higher than previous studies which used random forest with an accuracy of 95%. The study, therefore, confirms and recommends the models by the previous Arthurs as effective predictive models for diagnosing and predicting COVID-19 in a smart hospital environment.
Increased volume of the left hippocampal dentate gyrus after 4 weeks of bright light exposure in patients with mood disorders: a randomized controlled study
Authors: Hirakawa Hirofumi , Terao Takeshi , Hatano Koji , Shirahama Masanao , Kugimiya Tsuyoshi , Kohno Kentaro , Matsuta Hiroyuki , Shimomura Tsuyoshi , Fujiki Minoru
Published: June 2023

Bright light exposure (BL) induces neurogenesis in the rat hippocampal dentate gyrus (DG). We had previously conducted a randomized controlled trial (RCT) in which a 4-week period of BL in healthy participants resulted in increased volume of the left DG-head. This study aimed to investigate the effects of BL on the DG in patients with mood disorders. A 4-week RCT was conducted in which patients with mood disorders were randomly assigned to either a BL group (10,000 lx) or dim light exposure group (DL group; 50 lx). All patients underwent clinical assessment and magnetic resonance imaging at baseline and after the intervention. The study registration number is UMIN000019220. Our final sample included 24 patients (BL group, n = 12; DL group, n = 12). A significant effect of time and group was detected in the volumes of the left DG-head (F (1, 62.9) = 11.6, partial η2 = 0.35, p = 0.003) and left DG-total (left DG-total = left DG-head + left DG-body; [F (1, 86.8) = 6.5, partial η2 = 0.23, p = 0.02]). Additionally, the BL group demonstrated a significant increase in the volume of the left DG-head (95% CI: -5.4 to -1.6, d = 1.2, p = 0.002) and left DG-total (95% CI: -6.3 to -1.5, d = 1.06, p = 0.005) as well as a positive correlation between the percentage change in the volume of the left DG-total and the percentage change in the scores of the mood visual analogue scale (r = 0.58, p = 0.04). In conclusion, our study results suggest that compared to DL, BL leads to a significantly greater increase in the left DG volume in patients with mood disorders. This increase in the left DG volume may be associated with mood improvement in the patients.
Treatment of Kasabach-Merritt syndrome in infants' maxillofacial regions with local, accurate administration of urea combined with methylprednisolone
Authors: Hu Guangzhen , Dong Changxian , Cheng Mengyin , Huang Jing , Tian Xiaoqi , Liu Tingting
Published: June 2023

Infantile hemangioma is a common vascular tumor of infants. Kasabach-Merritt syndrome (KMS) is a rear but dangerous type of hemangioma. The present study analyzed the therapeutic and side effects of local administration of urea combined with methylprednisolone for the treatment of KMS in the maxillofacial region of infants. A retrospective study was conducted on the KMS patients in the department from July 2012 to September 2020. A total of 14 cases of KMS in infants’ maxillofacial region were treated with local injection of 40% urea solution and methylprednisone after the external carotid artery ligation. After 6–36 months of follow-up, 13 out of 14 cases were cured and 1 case was improved. During treatment, 2 cases relapsed and were treated continuously with local injection of urea for 6–10 more days. High efficacy and satisfactory recovery were observed in all cases after 1–2 months of treatment. No death or serious side effect occurred in the 14 cases. External carotid artery catheterization with urea and methylprednisolone injection is effective for the treatment of maxillofacial Kasabach-Merritt syndrome in infants. Careful postoperative observation and management of tube placement are important for the success of catheterization treatment.