bluuebunny/crossref_metadata_2025 huggingface dataset:
Eliminating Cancer Stem-Like Cells in Oral Cancer by Targeting Elementary Signaling Pathways
Authors: Joshi Jigna , Patel Hitarth , Bhavnagari Hunayna , Tarapara Bhoomi , Pandit Apexa , Shah Franky
Published: January 2023

Oral cancer is a heterogeneous, aggressive, and complex entity. Current major treatment options for the disease are surgery, chemo, and/or radiotherapy either alone or in combination with each other. Each treatment method has its own limitations such as a significant journey with deformities and a protracted rehabilitation process leading to loss of self-esteem, loss of tolerance, and therapeutic side effects. Conventional therapies are frequently experienced with regimen resistance and recurrence attributed to the cancer stem cells (CSCs). Given that CSCs exert their tumorigenesis by affecting several cellular and molecular targets and pathways an improved understanding of CSCs' actions is required. Hence, more research is recommended to fully understand the fundamental mechanisms driving CSC-mediated treatment resistance. Despite the difficulties and disagreements surrounding the removal of CSCs from solid tumors, a great amount of knowledge has been derived from the characterization of CSCs. Various efforts have been made to identify the CSCs using several cell surface markers. In the current review, we will discuss numerous cell surface markers such as CD44, ALDH1, EPCAM, CD24, CD133, CD271, CD90, and Cripto-1 for identifying and isolating CSCs from primary oral squamous cell carcinoma (OSCC). Further, a spectrum of embryonic signaling pathways has been thought to be the main culprit of CSCs' active state in cancers, resulting in conventional therapeutic resistance. Hence, we discuss the functional and molecular bases of several signaling pathways such as the Wnt/beta;-catenin, Notch, Hedgehog, and Hippo pathways and their associations with disease aggressiveness. Moreover, numerous inhibitors targeting the above mentioned signaling pathways have already been identified and some of them are already undergoing clinical trials. Hence, the present review encapsulates the characterization and effectiveness of the prospective potential targeted therapies for eradicating CSCs in oral cancers.
Towards developing partnership models for leveraging design for manufacture and assembly for school buildings
Authors: Weththasinghe Kumudu Kaushalya , Wong Peter S P
Published: January 2023

The substantial efforts made in implementing design for manufacture and assembly (DfMA) in construction developments thus far have been scattered. Past research has focused on the operational practice of volumetric and non-volumetric assembly, component manufacture and sub-assembly and modular building. This paper seeks to cover a comprehensive review with case studies to explore how DfMA can be leveraged in the design and delivery of school buildings. Three case studies were conducted to demonstrate how DfMA methods were applied in actual projects, identifying the challenges and issues confronted. The adopted techniques and involved challenges in school building projects were identified along with the capability and risk profiles that come with the opportunities to lead DfMA projects. Re-engineering as an aspect to engage in DfMA-led construction developments and how this may impact the current services of a construction firm were evaluated. The results reveal effective partnership models for establishing a sustainable business model for DfMA school buildings followed by a project feedback collection model. The partnership models developed provide guidance on establishing relationships to achieve the maximum potential of DfMA in school projects. The project feedback collection model promotes better circulation of lessons learned for advancement in future projects.
Inovação no associativismo territorial no Brasil: os Arranjos de Desenvolvimento da Educação
Authors: Grin Eduardo José , Abrucio Fernando Luiz
Published: January 2023

O artigo analisa os Arranjos de Desenvolvimento da Educação como forma de associativismo territorial que, no Brasil, desde os anos 2000, tem sido mais uma alternativa de consorciamento intermunicipal. O objeto de análise são dois casos: o Corredor da Vale (Maranhão) e a Chapada Diamantina (Bahia). A pesquisa foi realizada com base em dados secundários e uma investigação de campo que entrevistou gestores municipais de educação e representantes dos governos estaduais. A seleção dos casos baseou-se na metodologia do diverse cases que analisa, controladas as variáveis, diferentes efeitos da variável independente sobre a variável dependente. O argumento central testado é que os Arranjos de Educação são a variável independente que produz efeito na governança territorial da educação como variável dependente. Concluiu-se que o maior êxito do caso baiano deveu-se aos fatores de liderança regional, controle social e ao contexto e trajetória de sua formação, o que não ocorreu no caso maranhense.
Análise do desenvolvimento de organizações públicas a partir da governança de uma rede de cooperação para a produção de biodiesel em Sergipe
Authors: Olave Maria Elena Leon , Vaz Vitor Hugo da Silva , Vital Brazil Osiris Ashton
Published: January 2023

Uma das principais funções de uma governança é a de gerar contribuições para organizações que compõe uma rede. Nessa perspectiva, foi realizada uma pesquisa exploratória com um estudo de caso único em uma rede de instituições que tinha como objetivo central estruturar uma cadeia de produção e uso do biodiesel no Estado de Sergipe, intitulada: “Rede Biodiesel Sergipe”. O objetivo da análise foi verificar como a governança da Rede pode apresentar diferentes contribuições à gestão em organizações públicas federais. Os resultados mostraram que a governança se mostrou eficiente na geração de negócios para uma instituição bancária que ganhou na captação de clientes e elaboração de novas linhas de financiamento. Para uma universidade, a governança colaborou para a geração de grupos de pesquisa, captação de novos pesquisadores e geração de estudos e pesquisas. Já para uma instituição de pesquisa rural, as contribuições também foram associadas ao desenvolvimento de pesquisas. Por fim, para uma empresa produtora de energia, as contribuições foram associadas à geração de novos negócios e atuação em um novo ambiente.
Uji Daya Hasil Beberapa Galur Mutan Harapan Sorgum Manis (Sweet Sorghum) di Gunung Kidul, Yogyakarta
Authors: SP Sihono, , Indriatama W M , Maryono M Y , Human S
Published: January 2023

Sorgum manis memiliki potensi besar untuk dibudidayakan dan dikembangkan di Indonesia karena secara umum bijinya dapat digunakan sebagai sumber pangan alternatif dan cairan (jus) batang dapat dikonversi sebagai bahan baku bioethanol. Pemuliaan tanaman sorgum manis dilakukan dengan teknik mutasi induksi menggunakan radiasi sinar gamma di Pusat Riset dan Teknologi Aplikasi Isotop dan Radiasi (PRTAIR), Organesasi Riset Teknologi Nuklir (ORTN). Tujuan penelitian adalah untuk mendapatkan mutan yang memiliki karakteristik pertumbuhan dan hasil yang lebih baik dari tanaman induknya. Sebanyak 9 galur mutan harapan sorgum manis telah dihasilkan memiliki sifat produksi biji dan biomasa tinggi serta batang lebih manis. Galur-galur mutan harapan tersebut pada musim kemarau 2020 diuji daya hasilnya di Gunung Kidul, Yogyakarta. Galur mutan GH9 menghasilkan biji tertinggi (8.37 t/ha), GH5 memiliki produksi biomassa tertinggi (75.47 t/ha) dan GH1 memiliki kadar nira tertinggi (14.22 % brix).
STERILISASI MIKROBA BUBUK TALC MENGGUNAKAN SINAR GAMMA (Co-60)
Authors: Misriyani Misriyani , Poerwadi Bambang
Published: January 2023

Kerusakan produk bedak talek umumnya disebabkan oleh pertumbuhan mikroba. Beberapa industri mengatasi masalah ini dengan menggunakan teknik pengawetan iradiasi sinar gamma (Cobalt-60). Penelitian ini mengidentifikasi jumlah mikroba yang tersisa dalam bedak talek dan struktur sel bakteri yang diiradiasi. Pada studi pendahuluan, proses iradiasi dilakukan dengan memberikan dosis iradiasi bedak talek yang terdiri dari 4 taraf yaitu 0kGy, 5kGy, 7kGy, dan 9kGy yang dilakukan di PT. Rel-ion Bekasi menggunakan sinar gamma irradiator (Co-60), dan dilanjutkan dengan uji mikrobiologi terhadap sisa mikroba dalam bedak talk yang diradiasi yang dilakukan di Laboratorium Biokimia Fakultas Sains Universitas Brawijaya. Pengujian terdiri dari penghitungan jumlah bakteri dengan metode plate count dan identifikasi struktur sel bakteri dominan menggunakan metode pewarnaan gram dan pengamatan mikroskopis. Hasil penelitian menunjukkan bahwa jumlah bakteri pada bedak talek menurun seiring dengan meningkatnya dosis iradiasi. Identifikasi struktur sel bakteri yang dominan pada bedak talk yang diiradiasi menunjukkan ciri-ciri bakteri Pseudomonas aeruginosa dengan koloni bulat, licin, putih, memberikan pigmen kehijauan pada medium, dan menunjukkan sel bakteri gram negatif, dengan struktur batang, kadang-kadang bergandengan dan bercabang tidak beraturan dan berwarna merah.
Competencia matemática y digital del futuro docente mediante el uso de GeoGebra
Authors: García-Lázaro Desiré , Martín-Nieto Rebeca
Published: January 2023

El alumnado universitario utiliza la tecnología a diario, por lo que, en ocasiones, ciertas competenciasdigitales se dan por supuestas. Sin embargo, es necesario que el futuro profesorado utilice su competenciadigital en contextos de aprendizaje, por lo que deben ampliarla en su formación académica y aplicarla confines didácticos. El objetivo de este trabajo es conseguir que el futuro profesorado, domine las técnicasrelacionadas con las transformaciones geométricas a la vez que mejora la competencia digital, matemáticay la didáctica de esta (Modelo TPACK). Para ello, se ha aplicado el Software libre de GeoGebra Classic, conla finalidad de que el alumnado en formación adquiera competencias para la enseñanza de conceptosgeométricos como los de simetría axial, central, inversión, rotación, traslación y homotecia. Se ha utilizadouna metodología mixta con diseño preexperimental con una muestra de 68 participantes pertenecientesa la asignatura de Matemáticas y su didáctica III del Grado en Educación Primaria de la Universidad ReyJuan Carlos matriculados durante el curso 2021/2022. La evaluación, los talleres y los datos del cuestionarioespecialmente diseñado permiten realizar un análisis cuantitativo y cualitativo. Los resultados sonmuy satisfactorios ya que la aplicación de GeoGebra Classic permite desarrollar estrategias que combinancompetencias de forma simultánea y se concluye que facilita y mejora la adquisición de competencia matemática y digital y simplifica algunas dificultades que surgen en el aprendizaje.
Teriparatide in a patient	with severe osteoporosis, hypoparathyroidism and thalassemia major
Authors: Graziani A , Cannito M , Putti MC , Camozzi V
Published: January 2023

β-Thalassemia Major (TM) is a form of beta-thalassemias. TM complications include, among others, osteoporosis, whose frequency, among TM patients, varies from 13.6% to 50%. The overall etiological mechanisms of TM-related osteoporosis remain unclarified. The primary approach to osteoporosis in patients with TM is the management of TM and its complications and the use of antiresorptive agents, such as Bisphosphonates (BPs), as the first line-drug of treatment. In this article, we present the case of 45 years old-woman with TM and severe osteoporosis, with multiple fractures, albeit the assumption of BPs for many years. The anti-fracture efficacy and safety of BPs are not well-established in TM patients. Data suggest that etidronate and zoledronic acid should be considered as first-line agents in the management of TM- associated osteoporosis. Regarding Teriparatide (TP), there are only a few case reports published about its use in TM patients. It is also noticed that, at the dismission of TP therapy, its benefits are rapidly lost. Finally, regarding romosozumab, our patient presents a significant cardiovascular risk due to the presence of insulin-treated Diabetes Mellitus (DM) and TM-related cardiomyopathy, suggesting we avoid this drug. This case report shows that the therapy of osteoporosis in patients with TM remains an open problem. TM patients often present multiple comorbidities which create limitations to osteoporosis’s treatment. Moreover, these comoboridites are often unavoidable risk factors for osteoporosis.
Adaptive menu: A review of adaptive user interface
Authors: Sushil Shrestha , Prashant Poudel , Siza Adhikari , Isha Adhikari
Published: January 2023

Intelligent User Interface (IUI) is an emerging interdisciplinary research area that focuses on improving the usability of existing user interfaces. Adaptive menus are the part of the IUI that is trying to improve existing menus’ usability by reducing the selection time. This paper surveys the most relevant studies that are carried out in this field. First, it introduces an Adaptive User Interface (AUI) and adaptive menus then describe various adaptation styles and adaptation policies that are being used in adaptive menus along with their benefits and drawbacks. It then lists the applications of adaptive systems and how they can be used, as well as the limitations and future direction of the work.
Effect of Diet Restriction on Renal Glutathione Metabolism in Mice
Authors:   The Pharmaceutical Society Of Korea, Lee Somin , Bae Ji Eun , Kwon Doyoung , Jung Young-Suk
Published: January 2023

Various benefits for the maintenance of metabolic homeostasis can be obtained through dietary restriction. Short-term fasting of mice may induce systemic metabolic remodeling, which may have a significant effect on the level of endogenous metabolites. This study was conducted to examine metabolic changes of sulfur-containing substances in the kidneys of fasted mice over 48 h. No change in the concentration of renal methionine was observed over 48 h; however, significant decreases in the concentrations of S-adenosylmethionine and S-adenosylhomocysteine were observed at both 24 and 48 h after fasting. A significant decrease in the concentration of renal cysteine was observed from 24 h, and this was maintained at 48 h. A significant decrease in the concentration of glutathione (GSH) was observed in the kidney at 48 h, whereas increased concentrations of taurine were observed 48 h after fasting. Although significantly increased expression levels of BHMT were observed, markedly decreased expression levels of CβS were observed at 48 h after fasting, indicating activated generation of methionine, but downregulation of cysteine synthesis. The expression level of γ-GCL was not altered by fasting for 48 h; however, a significant increase of cysteine sulfinate decarboxylase mediating the taurine synthesis was observed. Significantly decreased protein expression levels of solute carrier family 7 member 11, which imports extracellular cystine, were observed at 48 h. These results suggest that the renal methionine concentration was maintained during short-term fasting through an increase in the re-methylation of homocysteine. Moreover, a reduction in the concentration of cysteine was the result of an increase in the synthesis of taurine and a decrease in the uptake of extracellular cystine, which may result in a decreased concentration of renal GSH.
Discovery of 2-Anilinopyrimidine-based Selective Inhibitors against Non-small Cell Lung Cancer Cell Line H1975
Authors:   The Pharmaceutical Society Of Korea, Lee Jinyoung , Kim Sou Hyun , Kim Seung Tae , Kim Heegyu , Nguyen Huu Long , Jung Young-Suk , Yun Hwayoung
Published: January 2023

Small molecular EGFR-tyrosine kinase inhibitors (EGFR-TKIs) have been proved as a successful and powerful strategy for the treatment of non-small-cell lung cancer (NSCLC). Recent studies have reported that the T790M mutation in EGFR is the most prevalent factor in acquired resistance for NSCLC patients. In an effort to identify small molecules for the inhibition of T790M mutant EGFR, a screening of our in-house chemical library was conducted by an MTT assay. A set of 2-anilinopyrimidine derivatives was rationally selected and then evaluated for their antiproliferative activities against three different type of NSCLC cell lines H358 (EGFR wild-type), HCC827 (EGFR exon 19 deletion) and H1975 (EGFR L858R/T790M double-mutant). Compounds 9, possessing a piperidine in the part A and a 4-methylpiperidine in the part B, selectively showed inhibitory activity in the T790M mutant cell line. In addition, in silico studies of 9 utilizing a SwissADME tool exhibited good drug-like properties.
Recombinant expression and purification of HIV-1 RT v1
Authors: A Avilés Javiera
Published: January 2023

This protocol has been optimized for the recombinant expression of HIV-1 RT. The sequence of the plasmid encoding HIV-1 RT can be found on reclone.org. The goal of this protocol was to eliminate the use of large volumes for dialysis and its fast buffer exchange into storage conditions.
P8 COMPROMISO DOCUMENTAL v1
Authors: not provided cgarcia
Published: January 2023

La Universidad Católica establecerá las funciones de supervisión de los doctorandos mediante un compromiso documental firmado por: la universidad, el doctorando, su tutor y su director. Este compromiso será rubricado a la mayor brevedad posible después de la matriculación, y habrá de incluir un procedimiento de resolución de conflictos y contemplar los aspectos relativos a los derechos de propiedad intelectual o industrial que puedan generarse en el ámbito de los programas de doctorado.
PROCEDIMIENTO DE GENERACIÓN INFORME ANUAL REVISIÓN GARANTÍA DE CALIDAD v1
Authors: not provided cgarcia
Published: January 2023

Desde la EIDUCAM, es necesario establecer mecanismos de control que permitan a las Comisiones Académicas revisar diferentes aspectos relacionados con el desarrollo de nuestros Programas de Doctorado. El informe a desarrollar por las comisiones académicas contemplará los siguientes apartados:
0.1% BSA media prep and flow v1
Authors: Oppenheim Olya
Published: January 2023

Fetal Bovine Serum contains traces of ligands of the BMP pathway which affect the flow experiments with the ibidi perfusion system. replacing EGM2 with 2% with EGM2 with 0.1% BSA 4h prior to onset of flow (with same media) allows cells to respond better and collectively to flow.
The Effect of Community Managers on Online Idea Crowdsourcing Activities
Authors: Hornuf Lars ,   University of Bremen, Jeworrek Sabrina ,   Halle Institute for Economic Research / Otto von Guericke University Magdeburg
Published: January 2023

In this study, we investigate whether and to what extent community managers in online collaborative communities can stimulate community activities through their engagement. Using a novel data set of 22 large online idea crowdsourcing campaigns, we find that moderate but steady manager activities are adequate to enhance community participation. Moreover, we show that appreciation, motivation, and intellectual stimulation by community managers are positively associated with community participation but that the effectiveness of these communication strategies depends on the form of participation managers wish to encourage. Finally, the data reveal that community manager activities requiring more effort, such as media file uploads vs. simple written comments, have a stronger effect on community participation.
An Adversarial Dance: Toward an Understanding of Insiders’ Responses to Organizational Information Security Measures
Authors: Balozian Puzant ,   James Madison University, Burns A. J. ,   Louisiana State University, Leidner Dorothy E. ,   University of Virginia
Published: January 2023

Despite the increased focus on organizational security policies and programs, some employees continue to engage in maladaptive responses to security measures (i.e., behaviors other than those recommended, intended, or prescribed). To help shed light on insiders’ adaptive and maladaptive responses to IS security measures, we conducted a case study of an organization at the forefront of security policy initiatives. Drawing on the beliefs-actions-outcomes (BAO) model to analyze our case data, we uncover a potentially nonvirtuous cycle consisting of security-related beliefs, actions, and outcomes, which we refer to as an “adversarial dance.” Explaining our results, we describe a novel belief framework that identifies four security belief profiles and uncovers an underexplored outcome of IS security: insiders’ lived security experiences. We find that individuals’ unfavorable lived security experiences produce counterproductive security-related beliefs that, in turn, lead to maladaptive behaviors. Maladaptive behaviors create new potential for security risk, leading to increased organizational security measures to counter them. Thus, the adversarial dance continues, as the new security measures have the potential to reinforce counterproductive security-related beliefs about the importance and risk of IS security and lead to new maladaptive behaviors. To help situate our findings within the current security literature, we integrate the results with prior research based on extant theories. While this paper is not the first to suggest that security measures can elicit maladaptive behaviors, the emergent belief framework and expanded BAO model of IS security constitute an important contribution to the behavioral IS security literature.
THE VIEW OF PROSPECTIVE SOCIAL STUDIES TEACHERS ON BLENDED LEARNING
Authors: BURSA Sercan
Published: January 2023

With the effect of technology and the pandemic, different approaches have begun to come to the fore in the understanding of education. Blended learning, which is one of these approaches, is known as the combination of distance education and face-to-face education with the support of educational technologies. It is becoming more widespread. Therefore teachers and prospective teachers are expected to be competent in blended learning. The aim of this study is to determine the views of social studies prospective teachers on blended learning. The data of this study, which was carried out in the basic qualitative research design, were obtained through semi-structured interviews. The data were analyzed inductively using the NVivo12 program. As a result of the research, it is seen that blended learning saves time and enables multidimensional learning. On the other hand, technological inadequacies and reduced socialization are seen as limitations of this approach. They state that there are many tools that can be used in this approach where the responsibilities of teachers and students increase. All of the participants say that they do not have sufficient knowledge about the application process and models of blended learning and they consider their undergraduate education insufficient in this regard. In line with the results of the study, it is recommended to include blended teaching practices in teacher education.
HOW ATTITUDES TOWARDS E-LEARNING AFFECTED THE ACADEMIC ACHIEVEMENT DURING THE COVID-19 PANDEMIC: AN EXAMPLE OF A NURSING SKILLS TEACHING
Authors: GURLEK KISACIK Oznur , SONMEZ Munevver , OZDAS Azize
Published: January 2023

It is known that the students' attitudes toward e-learning are an important factor in achieving the targeted learning achievement. The aim of the study was to determine the relationship between attitudes toward e-learning and the academic achievements of first-year nursing students during the COVID-19 pandemic. This cross-sectional and correlational study was conducted with a total of 135 first-year nursing students at a Department of Nursing in the Faculty of Health Sciences in Turkey. The total mean score of the first-year NSs' general attitude scale toward e-learning was found to be 52.58±15.93. A statistically negative correlation was found between the "avoidance of e‐learning" factor and the NSs' vital signs skills general achievement scores (r=-0.185; p= .035). Gender (β1= 5.399, p= 0.001), receiving adequate counseling and help on using the e-learning platform (β1=4.895, p= 0.022) and avoidance of e‐learning (β1= -0.222 p=0.046) explained 20.9% of the variance in vital signs overall achievement score. Negative attitudes and negative satisfaction with e-learning may lead to a decrease in e-learning academic achievement.
Reformatting Russian University in Hybrid War: Practice-Oriented Model
Authors:   Financial University under the Government of the Russian Federation, Balatsky Evgeny V. ,   RAS Central Economics and Mathematics Institute
Published: January 2023

The process of fragmentation of the global economy, which began in 2022, has put on the agenda a radical restructuring of the university system of the Russian Federation in the direction of increasing its practice-oriented orientation. The aim of the article is to substantiate the starting scenario of the reform on reconfiguration of personnel, organizational and managerial subsystems of Russian universities. In particular, it presents the general architecture of the practice-oriented model of Russian universities, taking into account the existing progressive experience. The required changes in personnel policy of the new three-level model of student education (x+y+z) and how they should be coupled with organizational changes within universities are disclosed. The principles of recruitment for modern universities, involving the implementation of the formula of combining three competencies "3-K", the model of teaching "3-U" and the principle of combining different places of work are considered. The mechanism for involving students in the production process is structured by: planning the structure of training and targeted training; senior year internships and a system of letters of recommendation; introduction of a system of working off budget education by distribution; organization of employment centers in universities; practice-oriented reorganization of graduate and doctoral studies. Issues of revising and updating curricula and disciplines in the social sciences are raised, as well as measures to debureaucratize the university system.
Openness of Authorities and Trust in The Region: Assessment Tools Based on Social Mining
Authors:   Southern Federal University, Kosolapova Nataliya A. , Nikitaeva Anastasia Y. ,   Southern Federal University, Golovacheva Maria M. ,   Southern Federal University
Published: January 2023

The study attempts to use scientometric analysis methods, social mining tools, and econometric modeling to show the relationship between the level of trust in regional economic systems and the openness of authorities. At the same time, trust is considered a risk factor in the development of economic systems due to the significant influence of this informal institution on the activities of economic entities with decision-making. The scientometric analysis of publications on the topic of the work made it possible to establish an exponential increase in the number of scientific articles on trust, openness, social networks, and the corresponding analytical tools. The constructed network maps of keywords made it possible to identify the largest thematic clusters reflecting the concentration of scientific works in research areas, firstly, related to data, algorithms, and technologies for their analysis, network users, and secondly, reflecting various aspects of organizational and individual behavior and what this behavior determines. The quantitative substantiation of the relationship between the openness of public authorities and the trust and involvement of the population was carried out by conducting factor analysis and constructing a regression model. Due to this, the study proved that the level of trust is more influenced by user engagement, which allows us to show the importance of a qualitative representation of the activities of authorities in social networks to increase the level of trust.
Digitalization in The Organizing of Apartment Building Major Renovation in Russia
Authors:   Southern Federal University, Ermishina Anna V.
Published: January 2023

The article substantiates the necessity and possibility of using information and communication technologies to reduce the severity and intensity of the principal-agent problem that arises in the modern system of organizing the major renovations of apartment buildings in Russia. Based on the “Arshtein ladder of civic participation” the article proposes a hierarchical model for a meaningful assessment of the existing resources of information and communication support for the major renovation system in Russia. This model includes seven levels of participation of homeowners in solving the problem of a building renovation. The analysis of the content and services of information support resources for the major renovation system of apartment buildings in Russia showed that they do not contribute to the practice of active real participation of homeowners in resolving issues of renovations, they are at the level of “symbolic” participation, providing information about the regulatory the legal framework for renovations, the structure of regulatory authorities in this area, the current activities of regional operators. The information support of the major renovation system of apartment buildings in Russia is an information flow from authorities to citizens, with a weak or absent feedback flow with the ability to control incoming initiatives and complaints, which does not allow us to state progress in mitigating the consequences of the principal-agent problem in this area.
Hemşirelik Öğrencilerinin Hastaların Kişisel Sağlık Verilerinin Kayıt ve Korunmasına Yönelik Tutumlarının Belirlenmesi
Authors: OLĞUN Sevil , ADIBELLİ Derya
Published: January 2023

Amaç: Bu çalışma, hemşirelik öğrencilerinin hastaların kişisel sağlık verilerinin kayıt ve korunmasına yönelik tutumlarını belirlemek amacıyla yapılmıştır. Yöntem: Tanımlayıcı tipteki araştırma bir devlet üniversitesinin hemşirelik fakültesi öğrencilerinde yapılmıştır (n=330). Araştırmanın verileri “Öğrenci Tanıtım Formu” ve “Kişisel Sağlık Verilerinin Kayıt ve Korunması Tutum Ölçeği (KVKKTÖ)” ile on-line toplanmıştır. Verilerin analizinde sayı, yüzde, ortalama, Mann Whitney-U testi, Kruskal-Wallis H t testi ve Spearsman’s Korelasyon analizi kullanılmıştır. Bulgular: Araştırmaya katılan öğrencilerin %74,3’ü kız, %48,3’ü 2. sınıftır. Öğrencilerin %87,1’inin “kişisel veri” kavramını, %70’inin “kişisel sağlık verisi” kavramını daha önce duyduğu ve %95,9’unun hasta bilgilerinin gizli tutulması gerektiğini düşündükleri saptanmıştır. Öğrencilerin KSVKKTÖ toplam puan ortancası 4,01±0,86 olup, 4. sınıf öğrencilerinin ölçeğin tüm alt boyutları ile ölçek toplam puanı yüksek ve anlamlıdır (p=0,000). Daha önce kişisel sağlık verisi kavramını duyan öğrencilerin yasal bilgiler ve yasal veri paylaşımı puanları duymayanlara göre yüksek ve istatiksel olarak anlamlıdır (p=0 .004). Sonuç: Öğrencilerin hastaların kişisel sağlık verilerinin kayıt ve korunmasına yönelik tutumlarının olumlu olduğu, 4. sınıf öğrencileri ile düz liseden mezun olanların hastaların sağlık verilerinin korunmasında daha fazla hassasiyet gösterdikleri sonucuna ulaşılmıştır.
Complications of neck dissection and their management: Retrospective study
Authors: Kumari Sheetal
Published: January 2023

Neck dissection (ND) is a surgical procedure performed in treating head and neck cancer patients with or without cervical nodal neck metastasis. The aim of neck dissection is to achieve loco-regional control thus optimizing the cancer cure rate. Various complications may potentially occur following this surgery. Previous studies done have documented the complication rate following neck dissection surgery to range between 5% to 15%. Most of the complications are inevitable and various efforts have been made to try and reduce complications by modifying the aggressive surgical procedure. The objective of this study is to report the various complications, its rate in various neck dissection procedures, their management and to seek improved patient care and outcome.

: A systematic review of 73 patients who underwent neck dissection for various head and neck cancers from August 2017 to July 2020. These patients were studied for post-operative complications and their management.

Out of 73 patients, Vascular injury observed in the current study was internal jugular vein (IJV) and was seen in 22.7%) cases and was repaired intraoperatively. Throracic duct injury was identified in 3(4.1%) and it was identified and ligated intraoperatively. Immediate post-operative complication being hemorrhage was seen among 2 cases, both the cases were re-opened. Marginal mandibular nerve and spinal accessory nerve injury was observed in 3 cases and they both came under the delayed type of complications.

: A careful preoperative assessment, meticulous surgical technique, high quality postoperative care and appropriate rehabilitation are the cornerstone of preventing and managing complications.
The bloated ear drum- A unique case of bullous myringitis
Authors: Vasudevan Chenchulakshmi , Hajare Priti S
Published: January 2023

Otological conditions range from a wide spectrum of congenital anomalies to inflammations, infections and complicated tumours that often not much is said about simple conditions such as myringitis. Bullous myringitis is not just a very unique condition but it also associated with a much-dreaded condition in the form of sudden SNHL and needs immediate diagnosis and timely treatment. Here we present to you one such case report and the management.
Absent stapedius muscle, tendon and pyramid – An anomaly revisited
Authors: Sood Rachit , Bhardwaj Abhishek , Malhotra Manu , Priya Madhu , Ravichandran Nivedhan , Yadav Akhilesh Chandra , Prasath Ramesh , Dave Jay
Published: January 2023

Congenital absence of stapedius is an exquisite entity, with an incidence of 0.5% and very few cases reported in live patients. We herein report a case of a middle-aged female presented with bilateral ear discharge and decreased hearing for more than a year, which, on examination, showed a large central perforation bilaterally, and an audiogram preoperatively revealed an average hearing loss of 45 dB and air-bone gap of 35dB bilaterally. Right endoscopic type I tympanoplasty was done, which unveiled absent stapedius muscle, tendon, and pyramid on the right side. The absent stapedius should circumspect the operating surgeon to look for other associated anomalies such as tympanosclerosis, fixed footplate and aberrant course of the facial nerve.
El reúso de agua residual tratada en América Latina y el Caribe: 10 estudios de caso
Authors: De la Peña Maria Eugenia , Larrea Christian J. , Sasaki Keisuke , Smith David
Published: January 2023

El crecimiento acelerado de la población así como los efectos del cambio climático contribuyen a la profundización de las desigualdades en el acceso a agua y saneamiento en la región de América Latina y el Caribe. Bajo este contexto, es necesario generar políticas y herramientas que permitan alcanzar el saneamiento seguro y reducir el impacto ambiental. Por ello, el tratamiento y posterior reúso de las aguas residuales tratadas, presentan una oportunidad a efecto de reducir la escasez, alcanzar la seguridad hídrica y el saneamiento ambiental.
Diagnóstico institucional del servicio civil en América Latina: Perú 2022
Authors: Strazza Luciano
Published: January 2023

Este informe de diagnóstico presenta los resultados de la evaluación del servicio civil de Perú, realizada en 2022 . Se basa en el marco metodológico elaborado en 2002 y en las buenas prácticas descritas en la Carta Iberoamericana de la Función Pública (CLAD y Naciones Unidas, 2003), que suscribieron todos los países de América Latina como el estándar hacia el cual debería apuntar la gestión del servicio civil. Este fue aplicado a la evaluación de 22 países de América Latina y el Caribe entre 2002 y 2005, incluido Perú . El informe de situación del servicio civil de este país, que se completó y se publicó en 2015, constituye la línea de base con la cual se comparan, en el presente diagnóstico, los avances y los desafíos todavía pendientes en términos de la profesionalización del servicio civil.
Mobilidade urbana e agenda ASG: um caminho para o desenvolvimento econmico e sustentável
Authors: Brakarz Barbara , Ribeiro Karisa , Arcia Diego , Santos Holanda Sandra Maria , Souza dos Santos Marcos Daniel , Araldi Fernando , Baima Carolina , Frota Gabriela Cyríaco da Silva , Barroso Carneiro Carla , Gomes Cardoso Leandro , Campos Pinheiro Romão Marina , Pareja Coelho Eduardo , Gonçalves Pinheiro Carolina , Marins Seixas Ian , Rodrigues de Melo Bruno Henrique , Pimentel Gustavo , Assali Tatiana , Ferrari Beatriz , Santana Carina , Fraga Isadora
Published: January 2023

A mobilidade urbana desempenha um importante papel social e no desenvolvimento das cidades. Em meio à crise climática, o setor é essencial para a recuperação verde, ou seja, para promover uma economia mais sustentável e resiliente, trazendo benefícios econômicos e sociais no médio e longo prazo. Melhorar a mobilidade urbana pode contribuir para reduzir as emissões de gases de efeito estufa, desenvolver novos projetos sustentáveis e implementar padres e acordos internacionais para uma transição econômica justa de baixo carbono. Esta nota técnica, elaborada entre o Ministério do Desenvolvimento Regional e o Banco Interamericano de Desenvolvimento, apresenta os seguintes temas: contextualização do setor de mobilidade urbana no Brasil sob a ótica ambiental, social e de governança (ESG); a integração das práticas ESG no setor de mobilidade urbana no Brasil, o financiamento da mobilidade urbana no Brasil e sua situação atual; e soluções para atração de capital privado, incluindo instrumentos elegíveis para o financiamento da mobilidade urbana no Brasil e apresentação dos instrumentos financeiros temáticos do setor.
One problem less: the true identity of Nemoura sahlbergi problematica Zwick, 1973 (Plecoptera: Nemouridae)
Authors: Murányi Dávid , Hwang Jeong Mi
Published: January 2023

By finding the epiproct slide preparation of the holotype of Nemoura sahlbergi problematica Zwick, 1973, which was considered to be lost, the identity of the taxon is resolved. It is raised to species rank, Nemoura problematica Zwick, 1973 stat. nov., and Nemoura jilinensis Zhu & Yang, 2003 is considered as its junior synonym. The species is widespread in the Korean Peninsula, known also from NE China (Jilin Province) and the Russian Far East (Khabarovsk and Primorsky Krai). New Korean records are listed, its distribution is detailed and depicted on map. Nemoura sahlbergi Morton, 1896 is known from the Russian Far East but not from China and Korea.
First wild capture of the Black Soldier Fly, Hermetia illucens (Linnaeus, 1758) (Diptera: Stratiomyidae) in Hungary
Authors: Murányi Dávid
Published: January 2023

The first wild caught Hungarian specimen of the Black Soldier Fly, Hermetia illucens (Linnaeus, 1758) is reported from Zala county, close to the Croatian border. Another specimen is reported from the northwestern lowland region of Albania, constituting the second record from the country. The Hungarian specimen may either came as an escape from maggot farming insect factory, or as a natural immigrant due to climate change. A phoretic mite was found on the antenna of the Hungarian specimen.
“EU NÃO DEIXO MAIS QUE TU SEJAS DE OUTRO HOMEM”
Authors: Vieira Mauro Cezar Borges
Published: January 2023

O presente artigo tem como objetivo analisar a violência contra a mulher como violação dos direitos humanos no romance Cais da Sagração, do escritor maranhense Josué Montello. Ao promover a interdisciplinaridade entre o direito e a literatura pretende-se evidenciar não só como que a os direitos humanos são violados em caso de violência contra a mulher como também demonstrar de que forma a literatura pode ser útil como plataforma para a reflexão acerca dos conceitos e temas jurídicos. Para a concretização do objetivo, utilizaremos como referencial teóricos os trabalhos de Hunt (2009), Azambuja e Nogueira (2008), Monteiro e Zaluar (2012), além do exemplo analítico da violência contra a mulher na literatura de Santos Filho e Matos (2020) e Almeida e Teixeira (2020), no que se refere propriamente ao romance de Josué Montello. Dessa maneira, devemos nos deparar com um cenário em que Vanju, mulher do protagonista Severino, tem seus direitos privados desde o início de seu relacionamento numa escalada de acontecimentos que terminará no seu trágico assassinado pelas mãos do marido.
HENRIQUE V E A MEMÓRIA NAS PEÇAS HISTÓRICAS DE SHAKESPEARE
Authors: Alves Vítor Nogueira
Published: January 2023

As peças históricas de Shakespeare levam ao palco eventos políticos do passado medieval inglês. Este artigo investiga como as peças históricas em geral, e Henrique V, em particular, lidam com questões da memória, da história e da invenção de uma identidade nacional. Tem-se proposto, ao menos desde Ernest Renan, que a existência de uma nação depende menos de uma identidade linguística, étnica ou religiosa e muito mais da existência de uma memória coletiva – e a memória sempre implica uma determinada interpretação do passado. Ao mesmo tempo em que se relacionam com concepções elisabetanas da história, as peças históricas de Shakespeare ajudam a imaginar um passado coletivo por meio da recordação e do esquecimento de eventos históricos.
NASCIMENTO MORAES
Authors: Cardoso Patricia
Published: January 2023

José do Nascimento Moraes exerceu as mais diferentes atividades no mundo das letras maranhenses, tornando-se um intelectual importante e referenciado na história da literatura nacional. Sua origem humilde e negra, que chegaram ao ponto de matizar a sua vida, também são grandes balizadoras de sua carreira no que concerne à temática racial e ao seu posicionamento diante do cenário político-social que contextualizava a sua produção. Com o intuito de divulgar cada vez mais a obra desse grande intelectual negro maranhense, o presente artigo tem o objetivo de analisar a trajetória intelectual e as obras desse escritor pensadas pelo viés da negritude e de seu envolvimento com a questão racial, percebendo-o como produtor de uma obra – literária e jornalística – que tem o Maranhão e a luta contra o preconceito racial como temas. Esse direcionamento constrói no campo intelectual uma literatura que é pujantemente negra, afro-brasileira e, sobretudo, afro-maranhense.
REPRESENTAÇÕES DA NOITE
Authors: Neres José
Published: January 2023

O objetivo deste artigo é fazer uma leitura crítica de “Poema das noites”, de autoria de Laura Rosa, e que foi publicado no jornal Folha do Povo, em novembro de 1925. Trata-se de um texto composto de quatro sonetos que têm como tema central a noite e alguns de seus aspectos simbólicos. Além da análise do poema, é feito um breve levantamento da vida e da produção literária da autora. O trabalho é oriundo de uma investigação de caráter bibliográfico, com pesquisa na hemeroteca virtual da Biblioteca Nacional, e culminou em uma leitura crítica dos textos que compõem o referido poema. Os principais autores utilizados na pesquisa foram Goulart e Silva (1997), Moisés (2004), Ferreira (2010) e Motta (2016).
Fostering Creativity through Narrative in the Age of AI
Authors:   The Korean Society For Teaching English Literature, Kang Sukjin , Lee Dong-hwan , Yang Young-yu , Kang Gyu Han , Lee Jong-Woo
Published: January 2023

In the age of AI, creativity is a key concept in education. English education requires to improve a student’s communicative capabilities through AI tools, without ignoring ambiguous, complex communicative situations that are difficult to handle with AI information systems. It is necessary to explore and express a student’s experience that cannot be easily handled through explicit rules and regulations of information systems including systematic coding. Narrative in English education encourages a creative imagination that frees students from communicative stereotypes, and promotes creative destruction for possible innovations. This paper suggests to nurture a student’s creativity by fully utilizing the narrative in English education classes. Students actively engage in narrative inquiries, recreating and recontextualizing languages instead of simply reproducing them. Foreign language learners should not be obsessed with survival need and confined the transactional language function of transmitting information. Narrative inspires them to develop their social and cultural selves through creative language use in new contexts. Narrative is an effective means to promote English communication skills and to forster creativity.
The Potential, utilization, and development of Geothermal Energy in Türkiye
Authors: ŞENER Mehmet Furkan , UZELLİ Taygun , AKKUŞ İbrahim , MERTOĞLU Orhan , BABA Alper
Published: January 2023

Geothermal energy is a natural resource that can be utilized directly or by converting to other types of energy. Considering the diversity of the geological structure of Türkiye, the geothermal systems have developed depending on young tectonic and volcanic active rock. Western and Central Anatolia are especially rich in geothermal resources. The geothermal well with the hottest well-bottom temperature was drilled in Central Anatolia, and the well-bottom temperature was measured as 341°C at a depth of 3845 meters. In 2022, Türkiye's electricity generation capacity and the total installed direct heat use reached 1663 MWe and 5113 MWt, respectively. Considering Anatolia's Curie depth and heat flux, the probable thickness of the batholith can be regarded as 10 km. For example, the total granitoid area of Western Anatolia is 4221 km2, and at least 2% of this granitoid can provide approximately 8x107 MWh of electricity by Enhanced Deep Geothermal Systems (EDGS). When all granites in Türkiye are considered, it is expected that the future capacity of Türkiye will be much higher with drilling research and development studies and the discovery of new fields. This capacity will exceed 100,000 MWt levels in the medium term, especially with the addition of EDGSs.
Análise da Propagação de Viroses Emergentes Influenciada por Fatores de Comportamento Humano e Ações Antrópicas
Authors: Moreira Marcos Antonio Cruz , Moreira Jacqueline Gatti , Huziwara Juliana Costa de Azevedo , Pereira Reis Kely Cristine Dalia , Lãczynski Lucilene Ollivier de Oliveira
Published: January 2023

A questão das doenças emergentes infecciosas e sua propagação é um tema mais urgente na atualidade do que em qualquer outra ocasião, tendo em vista a pandemia da COVID-19. Este trabalho propõe comparar a propagação de diferentes viroses emergentes, pandêmicas e epidêmicas. Avaliar a influência das ações antrópicas e do comportamento humano nestes processos, além de caracterizar os principais vetores nas viroses emergentes. Isto foi feito por meio de ampla revisão bibliográfica sobre o tema, abarcando publicações do final dos anos 1980 até 2020. Conclui-se que as modificações antrópicas associadas à agricultura intensiva fazem com que vetores se tornem sinantrópicos. A expansão em áreas novas provoca a entrada em nichos onde novos agentes podem ser encontrados. A criação extensiva porco–pato tradicionalmente praticada na China, coloca duas espécies em contato, favorecendo um laboratório natural para novas cepas recombinantes para gripe. No fator comportamento humano a facilidade de deslocamento, principalmente o transporte aéreo internacional, globalização, contribuem muito para rápida disseminação das doenças. Os resultados dessa pesquisa reforçam que a emergência das viroses está diretamente relacionada a fatores comportamentais humano e as ações antrópicas.