bluuebunny/crossref_metadata_2025 huggingface dataset:
The model of the TFL property of filter banks for nonlinear Optical OFDM/OQAM Systems Based on Volterra Series
Authors: Fang Xi , Mao Junying , Zhao Cheng , Jiang Guiqiu , Zhang Lei
Published: February 2021

In this paper, we propose the model of the filter banks’ TFL property for nonlinear optical OFDM/OQAM systems based on Volterra series. We analyze the energy concentration characteristics of different typical filters in nonlinear systems.
Date Augmentation for Constellation and Eye Diagrams Using Conditional Generative Adversarial Nets
Authors: Yu Wenjing , Wang Danshi , Xu Yilan , Zhang Min
Published: February 2021

For the constellation diagrams and eye diagrams in the field of optical research, a data augmentation method using the CGAN algorithm is proposed, to solve the problem of insufficient training data.
A 1766 nm Micro-Ring Laser with InGaAs/InGaAsP Quantum Wells for Potential Gas Sensing
Authors: Meng Fangyuan , Wang Mengqi , Yu Hongyan , Zhou Xuliang , Yang Wenyu , Chen Weixi , Zhang Yejin , Pan Jiaoqing
Published: February 2021

A multi-quantum-wells micro-ring laser based on whispering-gallery modes (WGMs) was fabricated and a single-mode lasing was obtained for the first time at 1766 nm under condition of 288 K, which showed potential for HCl and NO gas sensing.
High-performance meta-absorber for the surface wave under the spoof surface plasmon polariton mode
Authors: Deng Taowu , Liang Jiangang , Lou Jing , Zhang Chiben , Du Zhiqiang , Wang Canyu , Cai Tong
Published: February 2021

Perfect absorbers are highly desired in many engineering and military applications, including radar cross section (RCS) reduction, cloaking devices, and sensor detectors. However, most types of present absorbers can only absorb space propagation waves, yet absorption for the surface wave (SW) has not been researched intensively. In reality, when the space wave illuminates on the metal under large oblique angles, surface waves can be excited on the interface between metal and dielectric and thus would increase the RCS and influence the stealth performance. Here, based on the wave vector and impedance matching theories, we propose a broadband absorber for the surface wave under spoof surface plasmon polariton (SSPP) mode. The former theory ensures that surface waves can enter the absorber efficiently, and the latter guarantees perfect absorption. The experimental results indicate that our absorber can achieve a broadband (9.4-18 GHz) performance with an absorption ratio better than 90%, which is in great agreement with the simulations. Therefore, our device can be applied in RCS reduction for the metal devices, antenna array decoupling and many other applications. Also, this work provides a unique methodology to design new types of broadband surface wave absorbers.
Third optical harmonic generation reveals circular anisotropy in tilted silicon nanowire array
Authors: Ustinov Alexey S. , Osminkina Liubov A. , Presnov Denis E. , Golovan Leonid A.
Published: February 2021

In this Letter, we report on the circular anisotropy of third-harmonic (TH) generation in an array of silicon nanowires (SiNWs) of approximately 100 nm in diameter tilted to the crystalline silicon substrate at an angle of 45°. Numerical simulations of the scattering at the fundamental and TH frequencies of circularly polarized light by a single SiNW and an ansatz structure composed of 13 SiNWs used as a geometrical approximation of the real SiNW array indicate asymmetric scattering diagrams, which is a manifestation of the photonic spin Hall effect mediated by the synthetic gauge field arising due to the special guided-like mode structure in each SiNW. Despite strong light scattering in the SiNW array, the experimentally measured TH signal demonstrated significant dependence on the polarization state of incident radiation and the SiNW array spacial orientation in regard to the wave vector direction.
Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells
Authors: Giannios Panagiotis , Casanova Jordi
Published: February 2021

During the development of a holometabolous insect such asDrosophila, specific group of cells in the larva survive during metamorphosis, unlike the other larval cells, and finally give rise to the differentiated adult structures. These cells, also known as Adult Progenitor Cells (APCs), maintain their multipotent capacity, differentially respond to hormonal and nutritional signals, survive the intrinsic and environmental stress and respond to the final differentiation cues. However, not much is known about the specific molecular mechanisms that account for their unique characteristics. Here we show that a specificDrosophilaAPC gene,headcase(hdc), has a dual role in the normal development of these cells. It acts at a systemic level by controlling the hormone ecdysone in the prothoracic gland and at the same time it acts locally as a tissue growth suppressor in the APC clusters, where it modulates the activity of the TOR pathway and promotes their survival by contributing in the regulation of the Unfolded Protein Response. We also show thathdcprovides protection against stress in the APCs and that its ectopic expression in cells that do not usually expresshdccan confer these cells with an additional stress protection. Hdc is the founding member of a group of homolog proteins identified fromC.elegansto humans, where has been found associated with cancer progression. The finding that theDrosophila hdcis specifically expressed in progenitor cells and that it provides protection against stress opens up a new hypothesis to be explored regarding the role of the human Heca and its contribution to carcinogenesis.
Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors
Authors: Chen Rui , Hou Yanjun , Connell Marisa , Zhu Sijun
Published: February 2021

In order to boost the number and diversity of neurons generated from neural stem cells, intermediate neural progenitors (INPs) need to maintain their homeostasis by avoiding both dedifferentiation and premature differentiation. Elucidating how INPs maintain homeostasis is critical for understanding the generation of brain complexity and various neurological diseases resulting from defects in INP development. Here we report that Six4 expressed inDrosophilatype II neuroblast (NB) lineages prevents the generation of supernumerary type II NBs and premature differentiation of INPs. We show that loss of Six4 leads to supernumerary type II NBs likely due to dedifferentiation of immature INPs (imINPs). We provide data to further demonstrate that Six4 inhibits the expression and activity of PntP1 in imINPs in part by forming a trimeric complex with Earmuff and PntP1. Furthermore, knockdown of Six4 exacerbates the loss of INPs resulting from the loss of PntP1 by enhancing ectopic Prospero expression in imINPs, suggesting that Six4 is also required for preventing premature differentiation of INPs. Taken together, our work identified a novel transcription factor that likely plays important roles in maintaining INP homeostasis.
Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death
Authors: Balouch Bailey , Nagorsky Halle , Pham Truc , LaGraff James Thai , Chu-LaGraff Quynh
Published: February 2021

Infantile Neuronal Ceroid Lipofuscinosis (INCL) is a pediatric neurodegenerative disorder characterized by progressive retinal and central nervous system deterioration during infancy. This lysosomal storage disorder results from a deficiency in the Palmitoyl Protein Thioesterase 1 (PPT1) enzyme—a lysosomal hydrolase which cleaves fatty acid chains such as palmitate from lipid-modified proteins. In the absence of PPT1 activity, these proteins fail to be degraded, leading to the accumulation of autofluorescence storage material in the lysosome. The underlying molecular mechanisms leading to INCL pathology remain poorly understood. A role for oxidative stress has been postulated, yet little evidence has been reported to support this possibility. Here we present a comprehensive cellular characterization of human PPT1-deficient fibroblast cells harboring Met1Ile and Tyr247His compound heterozygous mutations. We detected autofluorescence storage material and observed distinct organellar abnormalities of the lysosomal and mitochondrial structures, which supported previous postulations about the role of ER, mitochondria and oxidative stress in INCL. An increase in the number of lysosomal structures was found in INCL patient fibroblasts, which suggested an upregulation of lysosomal biogenesis, and an association with endoplasmic reticulum stress response. The mitochondrial network also displayed abnormal spherical punctate morphology instead of normal elongated tubules with extensive branching, supporting the involvement of mitochondrial and oxidative stress in INCL cell death. Autofluorescence accumulation and lysosomal pathologies can be mitigated in the presence of conditioned wild type media suggesting that a partial restoration via passive introduction of the enzyme into the cellular environment may be possible. We also demonstrated, for the first time, that human INCL fibroblasts have a heightened susceptibility to exogenous reactive oxygen species (ROS)-induced cell death, which suggested an elevated basal level of endogenous ROS in the mutant cell. Collectively, these findings support the role of intracellular organellar networks in INCL pathology, possibly due to oxidative stress.
Improving the prioritization of children at the emergency department: Updating the Manchester Triage System using vital signs
Authors: Zachariasse Joany M. , Maconochie Ian K. , Nijman Ruud G. , Greber-Platzer Susanne , Smit Frank J. , Nieboer Daan , van der Lei Johan , Alves Claudio F. , Moll Henriëtte A.
Published: February 2021

Background

Vital signs are used in emergency care settings in the first assessment of children to identify those that need immediate attention. We aimed to develop and validate vital sign based Manchester Triage System (MTS) discriminators to improve triage of children at the emergency department.

Methods and findings

The TrIAGE project is a prospective observational study based on electronic health record data from five European EDs (Netherlands (n = 2), United Kingdom, Austria, and Portugal). In the current study, we included 117,438 consecutive children <16 years presenting to the ED during the study period (2012–2015). We derived new discriminators based on heart rate, respiratory rate, and/or capillary refill time for specific subgroups of MTS flowcharts. Moreover, we determined the optimal cut-off value for each vital sign. The main outcome measure was a previously developed 3-category reference standard (high, intermediate, low urgency) for the required urgency of care, based on mortality at the ED, immediate lifesaving interventions, disposition and resource use. We determined six new discriminators for children <1 year and ≥1 year: “Very abnormal respiratory rate”, “Abnormal heart rate”, and “Abnormal respiratory rate”, with optimal cut-offs, and specific subgroups of flowcharts. Application of the modified MTS reclassified 744 patients (2.5%). Sensitivity increased from 0.66 (95%CI 0.60–0.72) to 0.71 (0.66–0.75) for high urgency patients and from 0.67 (0.54–0.76) to 0.70 (0.58–0.80) for high and intermediate urgency patients. Specificity decreased from 0.90 (0.86–0.93) to 0.89 (0.85–0.92) for high and 0.66 (0.52–0.78) to 0.63 (0.50–0.75) for high and intermediate urgency patients. These differences were statistically significant. Overall performance improved (R2 0.199 versus 0.204).

Conclusions

Six new discriminators based on vital signs lead to a small but relevant increase in performance and should be implemented in the MTS.
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis
Authors: Zhang Hongxia , Zeng Lingbing , Liu Qiong , Jin Guilin , Zhang Jieyu , Li Zengbin , Xu Yilian , Tian Huizhen , Deng Shanshan , Shi Qiaofa , Huang Xiaotian
Published: February 2021

Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT1 accumulation and localization, thus interfering with its interaction with CDK7. Furthermore, CVB3 VP1 could suppress CAK complex enzymic phosphorylation activity towards RNA Pol II and CDK4/6, direct substrates of CAK. VP1 also suppresses phosphorylation of retinoblastoma protein (pRb), an indirect CAK substrate, especially at phospho-pRb Ser780 and phospho-pRb Ser807/811 residues, which are associated with cell proliferation. Finally, we present evidence using deletion mutants that the C-terminal domain (VP1-D8, 768-859aa) is the minimal VP1 region required for its interaction with MAT1, and furthermore, VP1-D8 alone was sufficient to arrest cells in G1/S phase as observed during CVB3 infection. Taken together, we demonstrate that CVB3 VP1 can inhibit CAK complex assembly and activity through direct interaction with MAT1, to block MAT1-mediated CAK-CDK4/6-Rb signaling, and ultimately suppress cell proliferation in pancreatic cells. These findings substantially extend our basic understanding of CVB3-mediated pancreatitis, providing strong candidates for strategic therapeutic targeting.
Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins
Authors: Bouwman Kim M. , Tomris Ilhan , Turner Hannah L. , van der Woude Roosmarijn , Shamorkina Tatiana M. , Bosman Gerlof P. , Rockx Barry , Herfst Sander , Snijder Joost , Haagmans Bart L. , Ward Andrew B. , Boons Geert-Jan , de Vries Robert P.
Published: February 2021

Receptor binding studies on sarbecoviruses would benefit from an available toolkit of recombinant spike proteins, or domains thereof, that recapitulate receptor binding properties of native viruses. We hypothesized that trimeric Receptor Binding Domain (RBD) proteins would be suitable candidates to study receptor binding properties of SARS-CoV-1 and -2. Here we created monomeric and trimeric fluorescent RBD proteins, derived from adherent HEK293T, as well as in GnTI-/- mutant cells, to analyze the effect of complex vs high mannose glycosylation on receptor binding. The results demonstrate that trimeric, complex glycosylated proteins are superior in receptor binding compared to monomeric and immaturely glycosylated variants. Although differences in binding to commonly used cell lines were minimal between the different RBD preparations, substantial differences were observed when respiratory tissues of experimental animals were stained. The RBD trimers demonstrated distinct ACE2 expression profiles in bronchiolar ducts and confirmed the higher binding affinity of SARS-CoV-2 over SARS-CoV-1. Our results show that complex glycosylated trimeric RBD proteins are attractive to analyze sarbecovirus receptor binding and explore ACE2 expression profiles in tissues.
Canton Express: Urbanization and contemporary Chinese art
Authors: Tam Isabella
Published: February 2021

Canton Express was a project situated within the larger exhibition Zone of Urgency in the Venice Biennale in 2003. It was the first comprehensive exhibition focusing on the relationship of urbanization and cultural landscape in the Pearl River Delta and presented on an international platform. Since the open-door policy in 1979, the Pearl River Delta played a pioneering role in China’s economic reform and urbanization throughout the 1980s and 1990s. This was resulted with unprecedent transformation of the cityscape and inhabitants’ lifestyle. More importantly, it defined the artistic context and character of the southern region uniquely from other parts of China, providing an opportunity for an alternative narrative in the discourse of contemporary Chinese art. Taking Canton Express as a case to reflect the uncanny observations and immediate responses among the fourteen participating artists and collectives on the new reality brought by urbanization and economic development which may, however, conflicted with the socialist-communist political ideology. And such tension nevertheless triggered a collective consciousness in the artistic community and their traits of flexibility, openness and self-autonomy to seek for an artistic identity independent from the existing narrative of contemporary Chinese art legitimized by the officials for biennales held inside and outside China. On this note, the essay will point out Canton Express proposed an interdisciplinary curatorial methodology for positioning ‘urbanism’ in the discourse. It will also provide examples of how it was instituted into the official system, expanding the multiplicity of contemporary Chinese art other than the market and political symbols, and shifted attention to art productions from a local perspective with global resonance. Through Canton Express and curatorial projects held afterwards, this essay attempts to prompt future research and discussion on qualities and conditions for artistic production and circulation of Chinese art in a world emerging from the COVID-19.
Keepers of the Waters: Experiments in xianchang art practice in 1990s China
Authors: Lin Nancy P.
Published: February 2021

The environmental art project, Keepers of the Waters, organized by the American artist Betsy Damon, invited artists from the United States and China to create artworks in and around a polluted urban river in Chengdu in 1995 and again in Lhasa, Tibet the following summer. The site-specific event occurred outdoors – outside institutional spaces of art – and showcased experimental performance and installation, formats that had previously been excluded from state-run museums in China due to state censorship. Although recent scholarship has examined socially engaged projects of the early 2000s that drew from global trends of social activism, relational aesthetics, and site-specificity, little work has been done on this nascent moment in the 1990s when Chinese artists began to draw connections between going outdoors, working in a site-specific manner, and advancing broader social commitments through their art. This study examines Keepers as a test site for a newly developing xianchang (on-site) aesthetic based on outdoor, site-specific engagements with social spaces. By situating Keepers within the specific historic concerns of the mid-1990s, I suspend the overly robust interpretive frameworks around art activism to uncover the nuanced ways in which xianchang art operated. As I demonstrate, the tensions and contradictions surrounding xianchang art challenge imported models on art’s social efficacy and continue to inform contemporary art practices in China into the twenty-first century.
Forest re-seen: From the metropolis to the wilderness
Authors: Preston Yan Wang
Published: February 2021

Rooted in practice-based research, the article uses the author’s artistic work as a springboard to discuss wider issues of ecology restoration, rewilding and environmental aesthetics. The first section of the article critically reviews and contextualizes the author’s eight-year photographic project, Forest, which investigates the politics of nature restoration projects in two new Chinese cities. Hinged upon contemporary environmental awareness and canonical photography aesthetics such as the topographic, the documentary and the storytelling, the Forest project pictorially and dialectically discusses the complexities of urban nature while beginning to accept urbanized China as a possible homeland. Extending the notion of constructed nature to an international context, within the global conversation efforts of re-naturalization and rewilding, the second section of the article analyses the inherent contradictions of rewilding in the post-wild world. The rewilded landscapes, the neo-wilderness, are brought into attention as a physical space to be investigated. The third section of the paper returns to its roots as practice-based research and tries to understand the neo-wilderness from the perspectives of landscape aesthetic traditions of both the West and China. The article finds commonality between three generations of representative western and male environmental photographers in their aesthetic choices and their philosophical grounding towards the sublime, pristine nature, as well as the binary between nature and culture. Finally, after a cautious discussion around the potential mis-use of Chinese traditional landscape aesthetics within contemporary landscape photography, the article points out the need to find alternative landscape aesthetics in order to critically investigate the meaning of nature now, with the constructed, rewilded landscapes as a crux for artists to produce an informed pictorial understanding.
Az interim menedzser szerepe a tudásmenedzsment-folyamatban
Authors: Bencsik Andrea , Gódány Zsuzsanna , Máthé Márta
Published: February 2021

A tudásmenedzsment kifejezetten kritikus lépése a tudásszerzés és megosztás, mely a hiányzó tudás pótlását hivatott szolgálni, a magasabb szintű szervezeti teljesítmény elérése érdekében. A szervezeti gyakorlat egyre több esetben fordul olyan megoldásokhoz, melyek külső forrásra támaszkodva szerzik be a szükséges tudást. Ezek közül egy lehetséges megoldás az interim menedzserek igénybevétele. E kvalitatív kutatás célja egy saját modell logikáját felhasználva azonosítani azokat a fázisokat, melyekben a tudásmenedzsment-folyamat és az interim menedzser tevékenysége összekapcsolódik. A szerzők strukturált mélyinterjú segítségével gyűjtöttek információt, melyet NVivo 12 program segítségével értékeltek ki. Az eredmény azt mutatja, hogy a tudásátadás és fejlesztés csak együttműködés esetén valósul meg, tudásgenerálás akkor, ha van közös gondolkodás, míg tudásfejlesztés azáltal, hogy összetett problémákat az egyéneknek egyedül kell megoldaniuk. A sikeres tudásátadás (és annak beépülése a szervezeti memóriába) feltétele minden esetben a megbízó és az interim menedzser között kialakuló bizalom. Az interim menedzser szükség esetén képes ellátni a tudásmenedzsment-folyamat valamennyi lépésének feladatait.
INVESTIGATION OF STRESS IN PRIMATES MAINTAINED IN ZOO AND ITS MAIN IMPLICATIONS ON BEHAVIOR AND WELL-BEING
Authors: Conceição Maria Gabriella , Sandra Conceição
Published: February 2021

O Brasil é considerado o país com maior número de espécies de primatas conhecidos. Ambientes de cativeiros que não possuem um programa de enriquecimento ambiental, é comum que fiquem desestimulados facilmente com a vida em cativeiro, principalmente em zoológicos, podendo desenvolver uma condição de estresse crônico. Objetivo: Levantar por meio de revisão integrativa, as causas do estresse em primatas mantidos em zoológicos, enfocando as reações decorrentes dessas alterações, bem como suas implicâncias no comportamento e bem-estar. Metodologia: Revisão integrativa da literatura utilizando os descritores “Fisiopatologia”, “Estresse”, “Primatas”, “Zoológicos” e “Bem-Estar” nas principais bases de pesquisa cientifica. Resultados: De 38 artigos encontrados, 30 foram incluídos. Conclusão: Conclui-se que variações individuais no perfil comportamental expõem os primatas de maneira diferente às condições estressoras. No zoológico, a visitação, a ausência de estrutura, a diminuição do recinto, o manejo nutricional incorreto e o ambiente sem estímulos, podem ser  potenciais fontes de estresse para alguns primatas alojados.  

Palavras chave: Fisiopatologia; Estresse; Primatas; Zoológicos; Bem-Estar.
Development of Subcarangiform Bionic Robotic Fish Propelled by Shape Memory Alloy Actuators
Authors: Muralidharan M. , Palani I.A.
Published: February 2021

In this paper, a shape memory alloy (SMA) actuated subcarangiform robotic fish has been demonstrated using a spring based propulsion mechanism. The bionic robotic fish developed using SMA spring actuators and light weight 3D printed components can be employed for under water applications. The proposed SMA spring-based design without conventional motor and other rotary actuators was able to achieve two-way shape memory effect and has reproduced the subcarangiform locomotion pattern. The positional kinematic model has been developed and the dynamics of the proposed mechanism were analysed and simulated using Automated Dynamic Analysis of Mechanical Systems (ADAMS). An open loop Arduino-relay based switching control has been adopted to control the periodic actuation of the SMA spring mechanism. The undulation of caudal fin in air and water medium has been analysed. The caudal fin and posterior body of the developed fish prototype have taken part in undulation resembling subcarangiform locomotion pattern and steady swimming was achieved in water with a forward velocity of 24.5 mm/s. The proposed design is scalable, light weight and cost effective which may be suitable for underwater surveillance application.
Statistical Evaluation of Burning Rate Data of Composite Propellants Obtained from Acoustic Emission Technique
Authors: Hoque Ehtasimul , Pant Chandra Shekhar , Das Sushanta
Published: February 2021

The acoustic emission technique has been considered to be one of the most reliable and robust methods for the measurement of the steady burning rate of composite propellants. In this work, attempts were made to quantify the measurement variability of the burning rate of composite solid propellants by acoustic emission method using statistical tools. A total of 1100 individual measurements were subjected to statistical treatment. The combination of confidence interval and repeatability limit delineated the extent of natural dispersion in the burning rate measurement data. The very high coefficient of variation values for the propellant compositions, having a burning rate of more than 25 mm s–1 raised concerns about the suitability of the acoustic emission method for high burning rate compositions. The Reliability interval approach was employed to determine the statistically significant sample size for different composite propellants having a burning rate range of 5–31 mm s–1. The entire set of data was screened for identification of outlying observation using the Dixon Q test, and the extent of contamination was quantified. Moreover, the application of statistical techniques could have far-reaching implications for quality control perspectives of burning rate measurement by acoustic emission and could be implemented as reference tolerance limits and preventive measures for ensuring the good health of the instrument as well as propellant processing.
A Wide Beam Printed Quadrifilar Helix based Circularly Polarised Radiating Element for Electronically Steered Antenna
Authors: Kumar Raj , Verma Pramendra Kumar , Kartikeyan M.V.
Published: February 2021

Wide beam and low axial ratio performance of printed quadrifilar antennas result in very attractive circularly polarised radiating element for wide scanned Electronically Steered Antenna. A compact printed quadrifilar Helix antenna (PQHA) has been designed and realised at S-Band frequency. Simulation and optimisation of designed antenna has been performed using ANSYS’s high frequency structure simulation (HFSS) software for its impedance, axial ratio (AR) performance and radiation characteristics. The developed circularly polarised antenna has 3-dB beam width of 130° and peak gain of 3.4dBic at 2.6 GHz. The developed antenna shows excellent AR performance over the frequency band as well as over the radiated beam. Half power axial ratio bandwidth of developed antenna is 27.4% (2.2 GHz - 2.9 GHz) while the impedance bandwidth is 32% (2.1 GHz - 2.9 GHz). Design has been validated through measured results. Designed wide band PQHA can be used as radiating element for electronically steered antenna for large beam steering application.
Iron level reduction effectivity at Water treatment instalation in Purworejo
Authors: Budianto Heru , Joko Tri , Dewanti Nikie Astorina Yunita
Published: February 2021

The iron (Fe) content in drinking water is higher than the standard which can cause technical, physical and health problems. Initial inspection at the outlet of the Drinking Water Treatment Plant in Purworejo showed iron levels of 0.575 mg / lt, so it is necessary to investigate its effectiveness.This study aims to determine the effectiveness of iron reduction level (Fe) in the Drinking Water Treatment Plant (IPAM) in Purworejo. This study uses a descriptive observational method, where data is collected, compiled, interpreted and analyzed so that it provides a complete description of the existing problems and then compares them based on theory, literature review, literature, scientific articles and with applicable regulations..The results of measurements of iron (Fe) levels on an average of 0.976 mg / lt inlet, 0.470 mg / lt outlet and 51.76% effectiveness. Standard iron (Fe) content in Permenkes Number 492 / Menkes / Per / IV / 2010 is a maximum of 0.3 mg / lt. The standard of effectiveness according to the Ministry of Home Affairs Research and Development with a result of 40% - 59.99% is in the ineffective category. The effectiveness of Iron (Fe) reduction in the Drinking Water Treatment Plant in Purworejo is in the ineffective category..
Przejawy pomocy sąsiedzkiej organizowanej on-line w czasie izolacji społecznej. Przykład inicjatywy Widzialnej Ręki w Poznaniu
Authors: Paluszkiewicz Maria , Olejniczak Artur
Published: February 2021

W dobie kryzysu epidemicznego, jaki nastąpił w 2020 r., pomoc sąsiedzka zyskała na wartości jak nigdy dotąd. Jedną spośród wielu akcji pomocowych była grupa facebookowa Widzialna Ręka zrzeszająca mieszkańców Poznania oraz okolicznych gmin. Celem społeczności Widzialnej Ręki jest pomoc osobom, które nie potrafią lub nie mogą odnaleźć się w trudnej sytuacji społecznej izolacji. W artykule przedstawiono wyniki badania obszaru działalności Widzialnej Ręki. Na podstawie tego studium przypadku określone zostały: forma, rodzaj, lokalizacja oraz grupy odbiorców pomocy sąsiedzkiej.
La moûsa canta la guerra: fragmentos de la cultura bélica por el mundo antiguo / Moûsa sings the war: fragments of the culture of war by the ancient world
Authors: Segundo Guzmán Miguel Ángel
Published: February 2021

Resumen. La guerra en el mundo antiguo fue densamente simbolizada en varios registros, penetró múltiples estratos de lo social. El presente escrito mostrará los diversos caminos que recorrió la tradición guerrera entre algunas de las más representativas fuentes literarias de la cultura griega antigua. La violencia militar fue una parte central en la construcción de los imaginarios y las prácticas de los sujetos. En el marco de una civilización agonística, permitió traducir la existencia social, tejiendo, por medio de sus símbolos, las distintas facetas del hombre. La guerra en la poesía adquirió una dimensión épica: las gloriosas narraciones hicieron posible apropiarse de la violencia, embelleciéndola para el oído masculino en el marco de una civilización signada por los ideales bélicos. Palabras clave: Guerra, épica, honor, Antigüedad, representaciones.Abstract. In the ancient world, war was heavily symbolized in various records, penetrating multiple layers of the social stratums. The present paper shows the various paths the warrior tradition crossed among some of the most representative literary sources of Greek culture. A central part of the imaginary construct and subjects practices was the war violence. As part of an agonistic civilization, it allowed translate social existence, weaving, by its symbols, the different facets of man. Through poetry, war acquired an epic dimension: glorious stories make possible appropriating violence, embellishing it for the male ear in context with a civilization signed by military ideals. Keywords: War, epic, honor, Antiquity, representations.
Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis
Authors: Liu Lei , Li Yanjun , Wang Jianing , Zhang Di , Wu Hao , Li Wenhui , Wei Huifang , Ta Na , Fan Yuyuan , Liu Yujiao , Wang Xiaohui , Wang Jun , Pan Xin , Liao Xudong , Zhu Yushan , Chen Quan
Published: February 2021

Mitophagy is an essential cellular autophagic process that selectively removes superfluous and damaged mitochondria, and it is coordinated with mitochondrial biogenesis to fine tune the quantity and quality of mitochondria. Coordination between these two opposing processes to maintain the functional mitochondrial network is of paramount importance for normal cellular and organismal metabolism. However, the underlying mechanism is not completely understood. Here we report that PGC‐1α and nuclear respiratory factor 1 (NRF1), master regulators of mitochondrial biogenesis and metabolic adaptation, also transcriptionally upregulate the gene encoding FUNDC1, a previously characterized mitophagy receptor, in response to cold stress in brown fat tissue. NRF1 binds to the classic consensus site in the promoter of Fundc1 to upregulate its expression and to enhance mitophagy through its interaction with LC3. Specific knockout of Fundc1 in BAT results in reduced mitochondrial turnover and accumulation of functionally compromised mitochondria, leading to impaired adaptive thermogenesis. Our results demonstrate that FUNDC1‐dependent mitophagy is directly coupled with mitochondrial biogenesis through the PGC‐1α/NRF1 pathway, which dictates mitochondrial quantity, quality, and turnover and contributes to adaptive thermogenesis.
Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture
Authors: Spits Menno , Heesterbeek Iris T , Voortman Lennard M , Akkermans Jimmy J , Wijdeven Ruud H , Cabukusta Birol , Neefjes Jacques
Published: February 2021

The endoplasmic reticulum (ER) is the largest organelle contacting virtually every other organelle for information exchange and control of processes such as transport, fusion, and fission. Here, we studied the role of the other organelles on ER network architecture in the cell periphery. We show that the co‐migration of the ER with other organelles, called ER hitchhiking facilitated by late endosomes and lysosomes is a major mechanism controlling ER network architecture. When hitchhiking occurs, emerging ER structures may fuse with the existing ER tubules to alter the local ER architecture. This couples late endosomal/lysosomal positioning and mobility to ER network architecture. Conditions restricting late endosomal movement—including cell starvation—or the depletion of tether proteins that link the ER to late endosomes reduce ER dynamics and limit the complexity of the peripheral ER network architecture. This indicates that among many factors, the ER is controlled by late endosomal movement resulting in an alteration of the ER network architecture.
Odimienne nazwy męskie w XVIl-wiecznych księgach parafialnych z Mokobód
Authors: Kuć Joanna
Published: February 2021

The author shows and characterizes one of the characteristic ways of identifying men by using forms coming from first names and using them as surnames on etymological and lexical level on the basis of anthroponomical material from the oldest historic office records coming from the border area of Mazowiecki–Podlaski dialect, that is XVII century parish records from the Mokobody parish. Over 200 such anthroponomies, functioning mainly among people from lower social classes, are the subject of the analysis.
Культурно-просветительская деятельность Иоанна, Евгения и Владимира Хлебцевичей на территории православного прихода Вознесения Господня в Клейниках в начале ХХ века
Authors: Kuprianowicz Adrian
Published: February 2021

Начало ХХ века, в клейницком приходе Вознесения Господня, связано прежде всего с оживленной деятельностью, в различных сферах семьи Хлебцевичей. Их пребывание и деятельность на территории клейницкого прихода, оставили значительный след в формировании менталитета и сознания жителей деревень и окрестностей того периода. Несомненно, что Иоанн, Евгений и Владимир Хлебцевичи были предтечами в своих замыслах и действиях, опережая при этом на многие годы эпоху, в которой им было дано жить. Многолетнее пребывание Яна Хлебцевича в Клейниках отличалось интенсивной пастырской работой, общественной деятельностью и большими усилиями, вложенными в развитие прежде всего церковно-приходского образования, а также открытием нескольких церковно-приходских школ вместе с библиотекой – читальным залом. В поле интересов Евгения Хлебцевича оказались литература, фольклор и история. К числу наиболее важных работ Владимира Хлебцевича, несомненно, следует отнести этнографический очерк, описывающий село Клейники, предшествовавшее периоду Первой мировой войны.
Initial Teacher Education in Hungary: Issues, Policies, Practices
Authors:   University of Debrecen, Faculty of Humanities, Chrappán Magdolna , Kopp Erika ,   Eötvös Loránd University, Faculty of Education and Psychology, Pesti Csilla ,   Karoli Gaspar University of the Reformed Church in Hungary, Faculty of Humanities and Social Sciences
Published: February 2021

Initial teacher education has gone through some radical changes in the past two decades: the two-cycled, Bologna-type system was introduced in 2006, but a few years later, in 2013 it was restored to the so-called undivided system. In resonance with international trends and national processes and developments, these reforms resulted in the appearance of some new elements in teacher education such as the mentoring system or the use of portfolios, while some other existing components with longer traditions (e.g. the pillar of practice schools) have gained even more importance. This paper aims to summarize and reﬂect on these changes and elements of initial teacher education through a critical pair of lenses, focusing on teacher preparation for lower and upper secondary education (ISCED levels 2 and 3) by contextualizing teacher education and revealing the challenges and progressive elements.
Measuring Instructor Self-Efﬁcacy when Migrating Face-to-Face Courses Online
Authors:   NYU Shanghai, Yuan Yanyue , Hargis Jace ,   NYU Shanghai, Center for Teaching & Learning
Published: February 2021

This study measures instructors’ online teaching self-efﬁcacy with an aim to capture their immediate and initial perception of migrating their teaching online and identify potential instructional needs and support. The authors sent a survey to all instructors in our institution four days prior to the ﬁrst day of classes in spring 2020 and received 73 responses (60% response rate). The number of years of experience with online tools was low (88%). Instructors reported high conﬁdence in their ability to teach online (82%); realization of the effort to create quality online experiences (90%); belief that teaching online would be different (90%); recognition of having to modify their assessment (77%); ability of adjusting teaching efﬁciently with unexpected events (82%); knowledge of where to seek teaching and technology guidance (86% & 89%); and conﬁdence in developing a similar rapport with students (71%). Respondents were split in their beliefs about offering similar active learning opportunities. This study supplements research on instructors’ perception of online teaching as a well-planned and intentional event, offering implications over the immediate and long-term support to be offered to instructors regarding migrating courses online both in times of crisis and when such opportunities arise.
Development Of Crossword Puzzles In The Learning Of Explanatory Text Summarization
Authors: Lestari Yunita , Sb. Nugraheti Sismulyasih
Published: February 2021

This research is based on Indonesian language learning that has not been effective yet, so the result of learned is not optimal yet, to overcome this problem, the researcher developed crossword puzzle game. This development research aims to produce crossword puzzle products as well as know the feasibility and effectiveness of the product. This research used Research and Developement method developed by Borg and Gall. The subjects of this study are the students of class V which amounted to 34 students. Data analysis techniques used descriptive percentage and n-gain test. The results showed that the media of crossword puzzles is very feasible to use with the percentage of assessment 89.58%, material expert judgments of 88, 63%. The result of N-gain analysis showed that the value obtained is 0.5226 in the medium category and the response is very good. Based on the result of the research, the crossword puzzle game to summarize the developed explanation text is declared eligible and effective in improving the writing skill of the students' explanatory text.
Development of Tie Dye Technique and Its Impact On Students Learning Outcome and Fine Motor Development
Authors: Putri Riska Yuliastanti , Ary Deasylina Da
Published: February 2021

This study aims to develop a color barrier technique in the class III charge of Cultural Arts and Skills at SDN Purwoyoso 06 Ngaliyan, Semarang. This research is a Research and Development (RnD) research with steps namely: potential and problems, data collection, product design, design validation, design revision, product testing, product revision, usage testing, product revision, and final product. The population of this study was 42 third grade students of SDN Purwoyoso 06 Ngaliyan Semarang. Data analysis techniques use product data analysis, learning outcomes, and student activities. The results of the study showed: (1) the development of color barrier techniques, namely the media and tools used and the motives produced. Based on expert validation shows the color barrier technique in the test of learning techniques experts and material get a percentage of 96.4% and 97.5% with very feasible criteria; (2) the use of color barrier techniques influences the effectiveness of SBK learning as evidenced by student learning outcomes with an average student score of 78.33%; (3) student activities obtain an average percentage of 94.83% with very high criteria. The conclusions of the study showed that the results of the development of the color barrier technique based on the validation of the learning techniques experts and the material fulfilled the criteria were feasible, could improve the effectiveness of student learning and activity.
55 The Effectiveness of Model Think Pair Share to Social Science Learning Outcomes of Grade III Students of Primary Schools in Unit Of Ahmad Yani District of Boja Kendal Regency
Authors: Yuliastuti Khanifah , Abbas Nuraeni
Published: February 2021

The problem found in Elementary School Ahmad Yani cluster Kendal was the low learning achievement of IPS subject. This was caused by several aspects such as the less varied learning model, the inability of students to use their own knowledge, and lack of critical thinking in problem solving. Therefore, there is a need to provide innovative model to create more effective teaching and learning process. To answer such problem, this study used Quasi-Experimental research method with Nonequivalent Control Group Design. Through this design, the researchers involved all the third grade of Elementary School in Ahmad Yani Cluster Kendal as the population of this study. They were sampled by using cluster sampling. After the samples were obtained, the researchers decided experimental and control groups. They were as many as 28 students of SD 2 Campurejo involved as the experimental group, while 22 students of SD 2 Tampingan as the control group. In addition, the dependent variable of this study was Think Pair Share model, while the independent variable was IPS subject learning achievement with the topic of the history of currency. Their data were collected using observation, documentation and tests. Meanwhile, the hypotheses and effectiveness were examined by using t-test and gain test. The results of the study showed that Think Pair Share model was effective toward IPS subject learning achievement of the third grade students with the topic of the history of currency. Further, the posttest average score of experimental class was higher than control class. Also, the posttest mean of experimental group was 78.6 and the posttest mean of control group was 67.7. Moreover, the calculation of gain index showed that experimental class was on fair category with the score of 0.6180, while the control class achieved the criteria as many as 0.4055. At last, this study suggests that TPS model is better to use in any subjects in order to create innovative teaching and learning.
MEDIA DEVELOPMENT OF MATERIAL BOOKLETS PRAYING PERSONAL POETRY FOR GRADE IV SD STUDENTS
Authors: Wulandari Tika , Sb. Nugraheti Sismulyasih , Sari Elok Fariha
Published: February 2021

Based on pre-research in class IV SDN Tambangan 01 found a lack of innovation. So it was been an impact on the low learning outcomes. Submission of material by the teacher still seems dominant. So a researcher wants to develop a media booklet. This study aims to develop a media booklet, studies the feasibility and effectiveness of the media booklet on the material express personal poetry in class IV SDN Tambangan 01 Semarang City. The method wich had been used in this research was a Sugiyono Research and Development (R&D) which consists of (1) potential and problem stages, (2) data collection, (3) product design, (4) design validation, (5) design revision, (6) product trials, (7) product revisions, (8) trials usage. The subjects of this stdy were several students in class IV SDN Tambangan 01 Semarang. Data collecting techniques were using observation, interviews, documentation, questionnaires, and tests. Data analyzing techniques were using product feasibility, initial and final data analysis (t test and N-Gain test). The result of the booklet feasibility test that from media experts obtained the percentage of 93.45% and the assessment of material experts obtained the percentage 91.6%. The booklet media effectiveness used in accordance with the result of the t test showed t arithmetic> t table (11,367> 1,697), then Ho was rejected and the pretest and posttest gain a result which was 0,552 with a criteria that support the effectiveness booklet media . The result of the questionnaire responses of teachers and students showed a very positive answer that make booklet media was more effective in its users.