bluuebunny/crossref_metadata_2025 huggingface dataset:
A Chinese telemedicine-dialogue dataset annotated for named entities
Authors: Wang Shanshan , Yan Yajing , Yan Rong , Li Ting , Ma Kaijie , YAN Yani
Published: April 2023

Background: A large collection of dialogues between patients and doctors are needed to be annotated for medical named entities to build intelligence for telemedicine. However, since most patients involved in telemedicine deliver related named entities in an informal and sentence-level multi-word expression way, it is challenging to tag them on the data of telemedicine dialogues. Under such circumstance, this study aims to address this issue.
Methods: On the data of telemedicine dialogues from Haodf, we have developed guidelines and followed two-round procedure to tag six types of named entities, including disease, symptom, time, pharmaceutical, operation, and examination. Moreover, we have experimented four deep-learning models on the dataset to establish a benchmark for named entity recognition.
Results: The distilled dataset contains 2,383 consultations between doctors and patients, 13,411 sentences from doctors, 17,929 from patients. The average characters per consultation is 1,100. There is 63,560 named entities on the whole, and average characters per named entity is 4.33.Moreover, the experiment results suggest that LatticeLSTM performs best on our dataset regarding all scores like accuracy, precision, F1, etc.
Conclusion: Compared with other exiting datasets, the novelties of this dataset are reflected in three facets: First, the intricated tagging of long multi-word expressions for medical named entity has been tackled in this study. Second, it is one of first attempts to mark temporal entities. Third, this dataset is balanced across the six types of labels. We believe that this dataset will play a considerable role in expanding telemedicine AI.
Reducing Tool-Tip Wear in Micro ECDM Scanning Process with Feedback Control of Flexible Contact Force
Authors: Nawaz Shan Ali , Cao Peiyao , Tong Hao , Li Yong
Published: April 2023

While machining the quartz glass in micro ECDM (electrochemical discharge machining) scanning process, the wear of tool electrode is adverse to machining accuracy. In this research, the developed spindle with servo feedback control of flexible force is used to avoid the instantaneous change of contact force that leads to the bending of tool electrode when the machining surface is uneven. The basic experiments are carried out through optimizing the processing parameters of open-circuit voltage, scanning speed, and scanning time, and then the mechanism and key influential factors of tool wear are analyzed. It is found that the tool wear is caused by the chemical reaction, the heat from discharges, and the friction between tool-electrode tip and workpiece surface. Therefore, three methods for reducing the tool wear are proposed and experimented. Method I: the low temperature electrolyte is applied in increasing the heat dissipation ratio of the tool-tip. Method II: the side wall of tool electrode is insulated by an oil film to constrain spark discharges only at the tool-tip bottom. Method III: more bubbles are pumped to promote the formation of gas film and the electrolyte renewal. Experimental results show the tool wear can be obviously reduced, so the machining accuracy of micro structures on quartz glass is improved in micro ECDM scanning process.
Huge Benign Ovarian Fibrothecoma, with endometrial polyp and meigs syndrome in a Postmenopausal Woman; Case Report and Review of Literature, 2023
Authors: Frezgi Okbu , Tesfai Berhe , Tesfamichael Tiblets , Hussein Khalid , Gebremariam Hailemichael , Wahaballa Yasir D
Published: April 2023

Introduction: - Ovarian sex cord-stromal tumours are rare, comprising only 8% percent of all primary ovarian tumours. Ovarian fibroma is the most common benign pure stromal tumour. It has no specific clinical manifestation, most of which are pelvic or adnexal masses.
Case report: - This is 59 years old woman came to Orotta National Referral Maternity Hospital On 02-2-2023 with complaint of abdominal distension and pain of one-year duration. The distention progressed slowly and she lost weight profoundly which she can’t quantified despite having good appetite. Her menses stopped 15 years back, then-after she denies any history of vaginal bleeding or discharge. She had no any alteration in bowel habit but she experiences occasional shortness of breath especially when she sleeps without pillow. she was chronically sick looking, in mild distress with respiratory rate 20 breaths/minute with chest was clear to auscultation with decreased air entry on right lower lung field. Abdomen was grossly distended, shiny without visible collateral vein. On palpation, she had huge abdominopelvic mass of about 36 cm by 20 cm, hard, mobile, with rough surface and irregular border. Her haemoglobin was 12.82g/dl and platelet of 504.7x103/µL. Trans-abdominal ultrasonography showed huge solid pelvic mass with ascites and hydrothorax. The serum level of cancer antigen 125 (CA125) was 91.28 U/mL, the carcinoembryonic antigen (CEA) was 34.87 ng/mL and alpha-fetoprotein (AFP) and CA19-9 were within normal range. At laparotomy, there was ascites and a huge globular mass measuring 30 cm was observed on the left ovary. The right ovary, uterus, omentum, and pelvic lymph node were unremarkable macroscopically. Postoperative recovery was uneventful and histopathologic result revealed left Ovarian Fibrothecoma with benign endometrial polyp.
Conclusion:- Ovarian fibrothecoma should be considered in women with pelvic pain and a large pelvic mass. In women with ascites and mildly elevated CA 125, the ovaries should be thoroughly investigated as they can be normal initially in imaging studies and gynaecological assessment. Radical surgical excision is the preferred treatment for postmenopausal women and is associated with a good prognosis.
Nanocellulose/natural latex composite film with high barrier and preservation properties
Authors: Meng Liucheng , Xi Jianfeng , Deng Yuqing , Ye Wenjie , Bian Huiyang , Xiao Huining , Wu Weibing
Published: April 2023

Nanocellulose films have been extensively studied for their excellent oxygen barrier properties. However, in the presence of moisture and higher humidity, the oxygen barrier performance decreases rapidly. In this work, natural rubber latex (NRL) was used as a compounding material to improve the hydrophobic properties of 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) oxidized nanocellulose fibers (TOCNF) due to the ability of its naturally occurring phospholipid-protein surface to avoid the interfacial compatibility problems that exist in most hydrophobic polymers when mixed in aqueous solutions. The exposure of the internal hydrophobic isoprene molecular chains of NRL during the drying process allows the composite film to have greatly improved water resistance and excellent water vapor and oxygen barrier properties. The water vapor permeability (WVP) and oxygen permeability (OP) of the films were as low as 6.07×10− 10g·mm/m2·s·pa and 3.11×10− 15 cm3·cm/cm2·s·Pa, respectively. And the good water resistance of the composite film makes the wet tensile strength of the film up to 15.87 MPa, which reaches 71.69% of the dry tensile strength. In addition, the high ductility of NRL makes the laminate film good toughness, and its elongation at break can reach about three times that of most nanocellulose-based films. Experiments on strawberry preservation with composite films have shown that it can effectively slow down the deterioration of strawberries and extend their shelf life from two days to seven days. This study highlights the exceptional promise of these innovative films for use in food packaging applications.
A Novel MRI Feature, the Cut Green Pepper Sign, Can Differentiate a Suprasellar Pilocytic Astrocytoma From an Adamantinomatous Craniopharyngioma
Authors: xu shumin , Yang Wan-Qun , Luo Yi , Wang Xiaoyu , Li Yaowen , Meng Xianlei , Zhang Yuze , Zeng Hongwu , Huang Biao
Published: April 2023

Objective
There are no specific magnetic resonance imaging (MRI) features that distinguish pilocytic astrocytoma (PA) from adamantinomatous craniopharyngioma (ACP). In this study we compared the frequency of a novel enhancement characteristic on MRI (called the cut green pepper sign) in PA and ACP.
Methods
Consecutive patients with PA (n = 24) and ACP (n = 36) in the suprasellar region were included in the analysis. The cut green pepper sign was evaluated on post-contrast T1WI images independently by 2 neuroradiologists who were unaware of the pathologic diagnosis. The frequency of cut green pepper sign in PA and ACP was compared with Fisher’s exact test.
Results
The cut green pepper sign was identified in 50% (12/24) of patients with PA, and 5.6% (2/36) with ACP. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the cut green pepper sign for diagnosing PA were 50%, 94.4%, 85.7% and 73.9%, respectively. There was a statistically significant difference in the age of patients with PA with and without the cut green pepper sign (12.3 ± 9.2 years vs. 5.5 ± 4.4 years, p = 0.035).
Conclusion
The novel cut green pepper sign can help distinguish suprasellar PA from ACP on MRI.
Determinants of Entrepreneurial Intention among Graduating Students in Ethiopian Universities: The Case of Madawalabu University
Authors: Asmare Hailemichael Mulie
Published: April 2023

The major objective of the study was to investigate the determinants of entrepreneurial intention among graduating students at Madawalabu University. For this end, data collected from 333 graduating students selected with stratified sampling technique. The Binary Logistic Regression Model was used to analyze the determinants of the entrepreneurial intention of graduating students. The result of the study revealed that only 41.5 percent of the graduating students reported their intention to start their own business and the majority of them preferred to join public and private organizations as career choices. From the cohort of fields of study, Business and Economics graduating students retorted a better entrepreneurial intention followed by Engineering and Technology graduate students. The model result revealed sex, prior experience, residence, parental role model perceived social norms, risk-taking readiness and propensity, and entrepreneurship education were the major significant determinants of the entrepreneurial intention of graduating students, and most of the variables included in the model were found to be determinants of entrepreneurial intentions that conform both theoretical and empirical literature. Therefore, policymakers need to design entrepreneurship courses in different curricula to nurture students towards self-employment and Universities should establish business incubation programs to nourish entrepreneurial talent at the university level.
Impact of Squatting on Selected Cardiovascular Parameters Among College Students
Authors: CHUKWUEMEKA UCHECHUKWU M. , BENJAMIN CHIMDINDU P. , UCHENWOKE CHIGOZIE I. , OKONKWO UCHENNA P. , ANAKOR ANTHONY C. , EDE STEPHEN S. , FABUNMI AYODEJI A. , AMAECHI IFEOMA A. , AKOBUNDU UZOAMAKA N.
Published: April 2023

Squatting is an active posture test used in assessing baroreflex sensitivity and the array of patients a physiotherapist handles, may benefit from this test to avoid the adverse effects of exercise. Therefore, this study aimed to evaluate the change in cardiovascular parameters that would occur during squatting among undergraduate students. 35 males (mean age = 22.94 ± 1.846) and 40 females (mean age = 22.28 ± 2.075) participated in this experimental study. Demographic data and baseline cardiovascular parameters (blood pressure and heart rate) were taken before exercise. The exercise protocol which was the squatting stress test was done for 2 minutes, after which post exercise blood pressure and heart rate were taken at an interval of one minute each. Paired and independent t-test was used to analyze the difference at 0.05 alpha level. It was found that there was a significant difference between pre and post-exercise blood pressure and heart rate in 1 and 2 minutes (p < 0.001) and also a significant difference in pre-exercise heart rate between lying and standing (p < 0.001). Also, there was no significant difference between 1 minute and 2 minutes post squatting exercise systolic blood pressure (p = 0.588), diastolic blood pressure (p = 0.381) and heart rate (p = 0.745). In conclusion,squatting trials among undergraduates revealed some statistically significant changes, especially between the cardiopulmonary parameters obtained in a standing position compared to lying, and those measured after one minute. Therefore, caution should be observed when administering exercises that require changes in posture.
Prediction of Groundwater Contamination in an Open Landfill Area Using a Novel Hybrid Clustering Based AI Model
Authors: Singh Prachi , Mahor Vikas
Published: April 2023

Groundwater is a vital resource that provides drinking water to over half of the world's population. However, groundwater contamination has become a serious issue due to human activities such as industrialization, agriculture, and improper waste disposal. The impacts of groundwater contamination can be severe, including health risks, environmental damage, and economic losses. In this research work a list of unknown groundwater contamination sources were developed for the Wang-Tien landfill using Groundwater Modeling System (GMS). Further, AI based models have been developed which accurately predicts the contamination from the sources at this site. A serious complication with most previous studies using Artificial Neural Network (ANN) for contamination source identification has been the large size of the neural networks. To simplify this, we have designed the ANN models which use three different ways of presenting inputs that are categorized by hierarchical k-means clustering. Such an implementation reduces the overall complexity of the model along with high accuracy. The predictive capability of developed models was assessed using performance indices and compared with the ANN models. The results show that the Hybrid model of hierarchical K-means Clustering and ANN model (HCA-ANN) is highly accurate model for identifying pollution sources in contaminated water.
COVID-19 Exacerbates Barriers to Health, Education, and Work for Adult Education Students
Authors: Griffith Frances J , Simmons Sydney C. , Shrader Shannon , Miller-Roenigk Brittany , Crouch Maria C. , Gordon Derrick M.
Published: April 2023

Systemic barriers contribute to attrition from K-12 education contexts and later involvement in adult education centers, especially among students from minoritized backgrounds. To assess the impact of stress-related risk factors, including trauma exposure and COVID-19-related stress, on ABE students and their barriers to academic and vocational success. Survey methods were used for data collection, and analysis of variance and structural equation modeling were used to test hypotheses. Results showed that past traumatic experiences were more common among ABE students who reported greater social or economic marginalization, especially those identifying as lesbian, gay, or bisexual or with a history of being unhoused. We observed that more traumatic experiences predicted higher COVID-19-related stress and alcohol misuse. Higher COVID-19-related stress, in turn, predicted lower job confidence. ABE students experiencing marginalization face compounded barriers to educational and vocational goals with trauma exposure and COVID-19-related stress. Based on findings, practice recommendations for ABE centers include targeted psychoeducational resources to offset systemic stressors and bolster academic and vocational attainment, such as on-site service delivery and using ABE centers as service system access points.
The role of miR1 and miR133a in new-onset atrial fibrillation after acute myocardial infarction
Authors: Zeng Qing Yi , Li Wei , Luo Zhenghua , Zhou Haiyan , Duan Zhong Gang , Xiong Xin Lin
Published: April 2023

Background: The development of new-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI) is a clinical complication that requires a better understanding of the causative risk factors. In this study, we aimed to explore risk factors and the expression and function of miR1 and miR133a in new atrial fibrillation after AMI.
Methods: We collected clinical data from 172 patients with AMI treated with emergency percutaneous coronary intervention (PCI) from October 2021 to October 2022. Independent predictors of NOAF were determined using binary logistic univariate and multivariate regression analyses. The NOAF predictive value was evaluated using the area under the receiver operating characteristic (ROC) curve for related risk factors. In total, 172 venous blood samples were collected preoperatively and on the first day postoperatively; the expression levels of miR1 and miR133a were determined by polymerase chain reaction. The clinical significance of miR1 and miR133a expression levels was determined by Spearman correlation analysis.
Results: The Glasgow prognosis score, left atrial diameter, and infarct area were significant, independent risk factors for NOAF after AMI. We observed that the expression levels of miR1 and miR133a were significantly higher in the NOAF group than in the non-NOAF group. On postoperative day 1, strong associations were found between miR133a expression levels and the neutrophil ratio and between miR1 expression levels and an increased left atrial diameter.
Conclusions: Our findings indicate that the mechanism of NOAF after AMI may include an inflammatory response that is associated with an increased miR1-related mechanism. Conversely, miR133a could play a protective role in this clinical condition.
Predictors of Pulmonary Embolism in Hospitalized Patients with COVID-19
Authors: Bahk Jeeyune , Rehman Abdul , Baloch Hafiza Noor Ul Ain , Zhang Jiafang , Yip Rowena , Lookstein Robert , Steiger David J
Published: April 2023

BACKGROUND:
High venous thromboembolism (VTE) rates have been described in critically ill patients with COVID-19. We hypothesized that specific clinical characteristics may help differentiate hypoxic COVID-19 patients with and without a diagnosed pulmonary embolism (PE).
METHODS:
We performed a retrospective observational case-control study of 158 consecutive patients hospitalized in one of four Mount Sinai Hospitals with COVID-19 between March 1 and May 8, 2020, who received a Chest CT Pulmonary Angiogram (CTA) to diagnose a PE. We analyzed demographic, clinical, laboratory, radiological, treatment characteristics, and outcomes in COVID-19 patients with and without PE.
RESULTS:
92 patients were negative (CTA-), and 66 patients were positive of PE (CTA+). CTA+ had a longer time from symptom onset to admission (7 days vs 4 days, p=0.05), higher admission biomarkers, notably D-dimer (6.87 vs 1.59, p<0.0001), troponin (0.015 vs 0.01, p=0.01), and peak D-dimer (9.26 vs 3.8, p=0.0008). Predictors of PE included time from symptom onset to admission (OR=1.11, 95% CI 1.03-1.20, p=0.008), and PESI score at the time of CTA (OR= 1.02, 95% CI 1.01-1.04, p= 0.008). Predictors of mortality included age (HR 1.13, 95% CI 1.04-1.22, p=0.006), chronic anticoagulation (13.81, 95% CI 1.24-154, p=0.03), and admission ferritin (1.001, 95% CI 1-1.001, p=0.01).
CONCLUSIONS:
In 158 hospitalized COVID-19 patients with respiratory failure evaluated for suspected PE, 40.8% patients had a positive CTA. We identified clinical predictors of PE and mortality from PE, which may help with early identification and reduction of PE-related mortality in patients with COVID-19.
Groundwater Quality Analyses of Selected wells in Ogbomoso North Local Government Area , Oyo State, Nigeria.
Authors: Adegbola A.A , Onawumi F.V
Published: April 2023

There has been an increasing groundwater usage through the abstraction of water from shallow wells without any form of treatment. The effect of using water from a shallow and untreated well is prone to water-borne diseases. This study investigated the groundwater quality of some selected wells in Ogbomoso North Local Government Area (LGA) of Oyo State, Nigeria. One hundred samples were collected for analyses in dry and rainy seasons using Global Positioning System (GPS 72) tools. The sampling points were located based on the existing delineation of ten (10) wards in the LGA, and their nearness to sources of possible pollution such as sewage, waste dump sites, mechanics workshop, cassava processing units, and drainages. These samples were subjected to physical (pH, turbidity), chemical (hardness, chloride, sulphate, zinc, chromium), and bacteriological (coliform and E-coli) examinations by using American Public Health Association (APHA) Standard procedures. The results of the analyses were compared to Nigerian Industrial Standards (NIS) and World Health Organization (WHO) Standards. Statistical analysis was carried out using descriptive (tables and percentages) analyses and inferential Analysis of variance (ANOVA) while a water quality map was developed by interpolating data obtained on a Geographical Information System (GIS) Arc map version 10.0 packages. The results of pH, turbidity, hardness, chloride, sulphate, zinc and chromium values of the samples ranged from 5.8-7.3 mg/l, 5.4-7.3 mg/l; 0-8 NTU, 0-1 NTU; 5.2-25.4 mg/l, 4.05-27.23 mg/l; 2.2-13.2 mg, 0.49-6.41mg/l; 103 15-604.29 mg/l, 44 9-191.42 mg/l; 0.00- 0.23 mg/l, 0.0 4- 0.19 mg/l; 0.00-0.27 mg/l, 0.01-0.19 mg/l for dry and rainy season, respectively. E-coli and T-coli values of the samples ranged from 16-64 mg/l; 20-52 mg/l and 20-64 mg/l; 12-68 mg/l for dry and rainy seasons, respectively. The mean effect of the tested parameters in the ten (10) wards is significantly (p<0.05) different for rainy and dry season. The developed water quality map indicated the strength of contaminants present in water in Ogbomoso North LGA. Hence treatment will be required for the wells investigated before domestic use.
Multifractal Detrended Fluctuation Analysis of Phonocardiogram signal and classification using Support Vector Machine
Authors: Houda Hakkoum Khaoula Nour El
Published: April 2023

The aim of this study is to discover and develop a reliable method to assist doctors in the early detection and diagnosis of heart disease, by analyzing the normal and abnormal Phonocardiogram signal (PCG)by using Multifractal Detrended Fluctuation Analysis (MFDFA) in order to comprehend and explore the underlying dynamics between pathological and normal case, as this method allowed extracting the most important characteristics of the PCG signal and also proved its effectiveness by 98.5075 % when classifying its results in support vector machine (SVM),the proposed method applied at MATLAB R2022b with record signals from PhysioNet and Michigan web site. The MFDFA technique appears to be promising in heart disease study
Development of finely tuned liposome nanoplatform for macrophage depletion
Authors: Choi Tae Hyeon , Yoo Ran Ji , Park Ji Yong , Kim Ji Yoon , Ann Young Chan , Park Jeongbin , Kim Jin Sil , Kim Kyuwan , Shin Yu Jin , Lee Yong Jin , Lee Kyo Chul , Chung Hyewon , Seok Seung Hyeok , Im Hyung-Jun , Lee Yun-Sang
Published: April 2023

Background Immunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome® and m-Clodrosome®) are limited by their inconsistent size and therapeutic efficacy. Thus, we aimed to achieve consistent therapeutic effects by effectively depleting macrophages with uniform-sized liposomes.Results We developed four types of click chemistry-based liposome nanoplatforms that were uniformly sized and encapsulated with clodronate, for effective macrophage depletion, followed by conjugation with Man-N3 and radiolabeling. Functionalization with Man-N3 improves the specific targeting of M2 macrophages, and radioisotope labeling enables in vivo imaging of the liposome nanoplatforms. The functionalized liposome nanoplatforms are stable under physiological conditions. The difference in the biodistribution of the four liposome nanoplatforms in vivo were recorded using positron emission tomography imaging. Among the four platforms, the clodronate-encapsulated mannosylated liposome effectively depleted M2 macrophages in the normal liver and tumor microenvironment ex vivo compared to that by Clodrosome® and m-Clodrosome®.Conclusion The newly-developed liposome nanoplatform, with finely tuned size control, high in vivo stability, and excellent ex vivo M2 macrophage targeting and depletion effects, is a promising macrophage-depleting agent.
Sub-sampled adaptive trust region method on Riemannian manifolds
Authors: Zhao Shimin , Yan Tao , Zhu Yuanguo
Published: April 2023

We consider the problem of large-scale finite-sum minimization on Riemannian manifold. We develop a sub-sampled adaptive trust region method on Riemannian manifolds. Base on the inexact information, the method adopts adaptive techniques to flexibly adjust the trust region radius. We present the iteration complexity is O(max ε-2g ε-1H, ε-3H) when the algorithm attains an (εg,εH)-second-order stationary point whichmatches the result on trust region methods. Numerical results for the PCA on Grassmann manifold and the Low-rank matrix completion are reported to demonstrate the effectiveness of the proposed Riemannian method.
Effects of remimazolam on cerebral oxygen saturation and postoperative cognitive function in elderly undergoing nasal endoscopic surgery: a retrospective exploratory study
Authors: Huang yingjie , Hu qian , Chen qiuhong , Chen qinqin , Liu bowen , Yang wenming , Zhang xuekang
Published: April 2023

Background Remimazolam is a new type of benzodiazepine, which has been widely used for general anesthesia and sedation. However, the association between remimazolam and intraoperative cerebral oxygen saturation and postoperative cognitive function in older patients undergoing nasal endoscopic surgery remains unclear. This study aimed to evaluate the effects of general anesthesia with remimazolam during nasal endoscopic surgery on intraoperative cerebral oxygen saturation and postoperative cognitive function in the elderly.Methods This single-center retrospective study reviewed data from patients older than 65 years who underwent nasal endoscopic surgery under general anesthesia at our institution between December 2020 and December 2021. Patient intraoperative regional cerebral oxygen saturation (rcSO2) and Montreal Cognitive Assessment (MoCA) scores were obtained from patient records. According to the sedatives used in anesthesia, the patients were divided into the remimazolam (R) and propofol groups (P) for analysis.Results Sixty patients were included in the final analysis (R group, n = 30; P group, n = 30). The relative maximum reduction of intraoperative rcSO2 was significantly lower in the R group than in the P group (P < 0.05), and the rcSO2 in the R group was significantly higher than in the P group (P < 0.05) after intraoperative controlled hypotension. However, there was no significant difference in MoCA scores between the two groups.Conclusion Remimazolam may benefit elderly patients during nasal endoscopic surgery in terms of rcSO2, but has no significant association with postoperative cognitive function.
Digital Inpainting of Mural Images Based on DC-CycleGAN
Authors: Xu Zhigang , Zhang Chenmin , Wu Yanpeng
Published: April 2023

Located in Dunhuang, northwest China, the Mogao Grottoes are a cultural treasure of China and the world. However, after more than 2,000 years of weathering and destruction, many murals faded and were damaged. This treasure of human art is in danger. Mural inpainting through deep learning can permanently preserve mural information. In order to reduce manpower and material resources, the efficiency of mural image restoration is significantly improved. Therefore, a digital restoration method combining Deformable Convolution (DCN), ECANet, ResNet and Cycle Generative Adversarial Network (CycleGAN) is proposed. We name it DC-CycleGAN. Compared with other image digital inpainting methods, the proposed DC-CycleGAN based mural image color inpainting method has better inpainting effects and higher model performance, which can better capture the high-frequency characteristics of the image and avoid network degradation and gradient disappearance. The digital restoration of mural images provides a new theoretical and scientific basis for the protection and restoration process of murals, and shows the latest attempts of mural restoration.
Overexpression of TPL2 may be a Predictor of Good Prognosis in Patients with Breast Invasive Ductal Carcinoma
Authors: Yu Qin , Wan Dan , Fu Rong , Li Feng , Zhang Yutao
Published: April 2023

Objective To investigate the roles and clinical significance of tumor progression locus 2 (TPL2) and peptidyl-prolyl cis–trans isomerase 1 (Pin1) in the occurrence and development of breast invasive ductal carcinoma (IDC).Methods Immunohistochemistry was performed to detect the expression status of TPL2 and Pin1 in paraffin-embedded human breast tissues, which included normal breast tissues (Normal), fibrocystic changes (FCC), ductal carcinoma in situ (DCIS) and IDC. The roles of TPL2 and Pin1 in the development of IDC, as well as the correlation between their expression status and clinicopathological parameters, were analyzed.Results Compared with Normal and FCC groups, the overexpression rates of TPL2 and Pin1 were significantly increased in DCIS and IDC groups. The expression of TPL2 and Pin1 was positively correlated in DCIS and IDC groups. In the IDC group, Ki67 expression in the TPL2 overexpression group was significantly lower than that in the TPL2 low expression group. The TPL2 overexpression rate was significantly higher in IDC with histological grades 1–2 than that in IDC with histological grade 3. The TPL2 overexpression rate in IDC with TNM stage I was significantly higher than that in IDC with TNM stages II–III. The overexpression of Pin1 was positively correlated with the positive expression of estrogen receptor (ER) in the IDC group.Conclusions TPL2 and Pin1 may synergistically promote the occurrence and development of IDC, but TPL2 overexpression may be an early molecular event in IDC development. The prognosis of IDC patients with TPL2 overexpression may be better, suggesting that TPL2 overexpression may be a predictor of good prognosis in IDC. The detection of TPL2 expression in IDC tissues may be a key approach to evaluate the prognosis of IDC patients in the future.
Divorce Prediction Using Machine Learning Algorithms in Ha'il Region, KSA
Authors: Alshawarbeh Etaf Saleh , Shafqat Ayesha , Alraqad Tariq , Moumen Abdelkader , Saber Hicham , Shafqat Ramsha
Published: April 2023

This paper presents a study in which the divorce predictor scale (DPS), based on Gottman couples therapy, was used to predict divorce. The 54 items in the DPS were used as features or attributes in a machine learning model. In addition to the DPS, a personal information form was utilized to gather participants' personal data in order to conduct this study in a more structured and traditional manner. Out of 148 participants 116 participants were married whereas 32 were divorced. With the use of algorithms Artificial Neural Network (ANN), Naïve Byes (NB) and Random Forest (RF), the effectiveness of DPS was examined in this study. The correlation based feature selection method was used to identify the top 6 features from the same dataset and the highest accuracy rate was 96.61\% with ANN. The results show that DPS can predict divorce. This scale can help family counselors and therapists in case formulation and intervention plan development process. Additionally, it may be argued that the Hail region, KSA sampling confirmed the Gottman couples treatment predictors.
Polymeric organogel as an effective approach for eradication of heavy metal ions As, Pb, Cd, and Cr from the surface of groundwater through adsorption stratagem
Authors: Baruah Kankana , Dutta Riku , Doley Simanta , Sarma Bipul , Dolui Swapan Kr.
Published: April 2023

Excess metal pollutant has affected and caused serious havoc in the lives of terrestrial as well as aquatic beings. The core of this work revolves around eradicating highly toxic heavy metal ions from underground water systems using a cost-effective, high removal efficiency polymeric adsorbent capable of adsorbing and removing ionic metals whose backbone is composed of a bio-degradable polymer, Polyvinyl alcohol. The obtained adsorbent was characterized using FT-IR, HNMR, and P-XRD. Morphological studies were carried out using SEM. Detection and adsorption of metal ions were performed using SEM-EDX and AAS; wherein the adsorbent was found to remove nearly 80% of Arsenic ions, 70.5% and 70.7% for Lead and Chromium ions while 60.7% for Cadmium ions respectively. Further, the kinetics of adsorption along with intraparticle diffusion studies were also performed to determine the mechanism alongside observing the isothermal influence of the sorbent. The adsorption capacity was seen to be highest in Arsenic at around 570.42mg/g thus acting as a potential and effective adsorbent for the removal of heavy metal ions from groundwater.
Evaluation of c-Fos protein expression and NADPH-d reactivity in Neurobion pretreated rat model of inflammatory pain
Authors: Zarei Shahab A. , Shahriari-Khalaji Mina , Andolina Ian Max , Behzadi Gila
Published: April 2023

B-vitamins have been evaluated as a useful adjuvant therapy to treat pain. In spite of clinical and experimental evidence indicating the analgesic effect of B-vitamins, few studies have investigated their effect on aspects of the inflammatory pain response. In the present study, we investigated the analgesic effect of chronic application of B-complex vitamins (Neurobion) using an inflammatory experimental pain model in rats. Nociceptive behavioral responses were evaluated in male Wistar rats after plantar injection of formalin, comparing groups with (TG) and without (CG) Neurobion pretreatment. In addition, neuronal activity in the central pain pathway was evaluated using c-Fos immunohistochemical reactivity and NADPH-d histochemistry. A highly significant reduction of painful behaviors such as licking and flinching were observed in TG, especially during the secondary phase of the formalin test compared to CG. Results suggest that long-term pre-treatment using Neurobion can have a beneficial effect in reducing the chronic phase of pain. In addition, we observed a downregulation of c-Fos and NADPH-d in dorsal spinal neurons, suggesting that the antinociceptive effect induced by Neurobion could be due to a suppression of nociceptive transmission at the spinal level, particularly in the afferent regions of the dorsal spinal horn, which these neurons utilizing nitric oxide at least as one of their pain neurotransmitters.
Study of Reconnection Dynamics and Plasma Relaxation in MHD simulation of a Solar Flare
Authors: Agarwal Satyam , Bhattacharyya Ramit , Yang Shangbin
Published: April 2023

Self-organization in continuous systems is associated with dissipative processes. In particular, for magnetized plasmas, it is known as magnetic relaxation, where the magnetic energy is converted into heat and kinetic energy of flow through the magnetic reconnection process. An example of such a system is the solar corona, where reconnection manifests as solar transients like flares and jets. Consequently, toward investigation of plasma relaxation in solar transients, we utilize the novel approach of data-constrained MHD simulation for an observed solar flare. The selected active region NOAA 12253 hosts a GOES M1.3 class flare. The investigation of extrapolated coronal magnetic field in conjunction with the spatiotemporal evolution of flare reveals a hyperbolic flux tube (HFT), overlying the observed brightenings. MHD simulation is carried out with the EULAG-MHD numerical model to explore reconnection dynamics. Three distinct sub-volumes are chosen and are subjected to analysis of magnetic field line dynamics along with time evolution of various physically relevant quantities like magnetic energy, current density, and twist. The overall simplification of field line complexity in each sub-volume, decay of magnetic energy and current density because of reconnection are found to be the prime signatures of relaxation. The size and position of chosen sub-volumes with respect to the boundaries of computational box are seen to play an important role in governing the overall dynamics. The terminal state of simulation for all the sub-volumes is checked for the well known Taylor(1974) predicted state of a linear force-free field configuration and we found the results to be not consistent with a linear force-free field. We think that the resolution, efficiency of reconnection in the simulation, and assumptions regarding selection of sub-volumes may have a bearing on the results, which we aim to explore in future works.
Radiological spectrum of rhino-occulo-cerebral mucormycosis
Authors: . Dinesh , Prasad Umakant , Suman Sanjay Kumar , Kumari Manisha , Waghmare Vaibhav
Published: April 2023

Aim and objectives
Aim
To study the spectrum of imaging findings in patients Rhino-occulo-cerebral mucormycosis (ROCM).
Objectives
l To study the demographic profile of patients with ROCM
l To detect the associated extrasinus complications of ROCM
l To aid in clinical diagnosis of ROCM
Materials & methods
This retrospective descriptive study was performed in histopathologically confirmed cases of ROCM. The case records of patients with radiological, culture and histological evidence of acute invasive rhinocerebral mucormycosis were retrospectively evaluated for relevant radiological and clinical data between May 2021 to June 2022.
Results
The radiological evaluation included CT and MRI scans were done in 52 patients. The patient's average age was 48 years. The ethmoid sinus was involved in 46 cases (88%) and the maxillary sinus in 27 cases (52%). Biltaral (45, 86%) and pansinus (27, 52%) involvement were the most common. The orbit was involved in 39 cases (75%), the face in 25 cases (47%), and retroantral fat stranding in 24 cases (46%). Mucosal thickening (91%) was the most common pattern of involvement, followed by complete opacification (37%). Osseous involvement was seen in 17 of 44 patients who had CT scans, and the majority of patients had extrasinus extension with intact bone. MRI revealed variable T2SI, with T2 hyperintensity being the most common pattern. Heterogeneous enhancement in post contrast imaging was the most common.
Conclusion
Rhinocerebral mucormycosis is characterised by a variety of imaging abnormalities on CT and MRI. In determining the degree of involvement and consequences, imaging is crucial.
Modified Duhamel pull-through vs. Trans-anal endorectal pull-through in children with Hirschsprung's disease: Outcome comparison from a single center over 14 years
Authors: Shankar Gowri , Umashankar Vidya Bangalore , Jadhav Vinay , Munianjanappa Narendrababu
Published: April 2023

Purpose To analyze and compare short-term results and long-term bowel function in patients with Hirschsprung disease (HD) following two commonly performed definitive surgeries at our institute: Modified Duhamel pull-through (MDPT) and transanal endorectal pull-through (TERP).Methods 103 cases of HSD who underwent pull-through procedures (MDPT, n = 71; TERP, n = 32) between 2007 and 2021 were included. Seventy-nine were assessed for bowel function by Rintala scoring (MDPT, n = 53; TERP, n = 26).Results The MDPT group had more early complications (40.84% MDPT vs. 25% TERP), including anastomotic leak (4.2%, n = 71) and adhesive intestinal obstruction (5.6%, n = 71). Rectal mucosal prolapse (3.1%, n = 32) and anal stricture (3.1%, n = 32) were noted exclusively following the TERP. Both groups had a similar incidence of HAEC (21% in MDPT vs. 20% in TERP). TERP group had more daily bowel movements post-pull-through (71.8% vs. 22.5% in MDPT). Bowel function was considered impaired, with Rintala score of < 17 in 61.5% of cases of TERP (vs. 16.9% of cases of MDPT, n = 53; P = 0.001).Conclusion In our institute, we found better bowel function outcomes following MDPT compared to TERP, with higher incidence of soiling and accidents following TERP. However, long-term outcomes following technical changes in performing the TERP procedure remains to be assessed.
Targeting GABARAPL1/HIF-2a in nasopharyngeal carcinoma
Authors: Huang Xiaopeng , Zhou Liya , Chen Jiawei , Zhang Shuai
Published: April 2023

The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling pathways. These pathways have inhibitory effects on autophagy, and autophagy has become an important area of NPC research. However, the potential molecular targets related to autophagy in NPC remain to be elucidated. The current study examined levels of autophagy-related genes, including autophagy related 4B cysteine peptidase (ATG4B) and gamma aminobutyric acid (GABA) type A receptor associated protein like 1 (GABARAPL1), in nasopharyngeal carcinoma tissues and explored their potential role as novel targets for the treatment of NPC. Overexpression of GABARAPL1 was shown to decrease the level of hypoxia-inducible factor (HIF)-2α and induce apoptosis in NPC cells. Importantly, when nude mice were subcutaneously inoculated with NPC cells, overexpression of GABARAPL1 slowed tumor growth. Furthermore, the underlying mechanism by which GABARAPL1 regulated nasopharyngeal tumor growth was investigated. HIF-2α, as a substrate for autophagic degradation, may play an interesting role during NPC progression. This study highlighted novel targets that may be used to treat NPC patients in the future.
Characterization of Primary Human Leptomeningeal Cells in 2D culture
Authors: Abubaker Mannthalah , Greaney Aisling , Newport David , Mulvihill John
Published: April 2023

Maintaining the integrity of brain barriers is critical for a healthy central nervous system. While extensive research has focused on the blood-brain barrier (BBB) of the brain vasculature and blood-cerebrospinal fluid barrier (BCSFB) of the choroid plexus, the barriers formed by the meninges have not received as much attention. These membranes create a barrier between the brain and cerebrospinal fluid (CSF), as well as between CSF and blood. Recent studies, particularly on the arachnoid barrier, have revealed its critical role in facilitating the exchange of substances between the brain and CSF. Moreover, this barrier has been implicated in the development of neurological and immunological disorders. In order to gain a deeper comprehension of the functioning and significance of the meningeal barriers, sophisticated models of these barriers, comparable to those of the BBB and BCSFB, need to be created. The aim of this paper is to investigate the characteristics of leptomeningeal cells (LMCs) that form the meningeal barriers, in a cultured environment, including their morphology, proteomics, and barrier properties, and to determine whether passaging of these cells affects their behavior in comparison to their in vivo state. The study employed techniques such as immunofluorescence, immunoblotting, and TEER to analyze the cells. The results indicate that higher passage numbers significantly alter the morphology and protein localization and expression of the LMCs. Additionally, cultured LMCs showed an increase in Vimentin and Cytokeratin expression and a lack of junctional proteins localization on the cell membrane, which could suggest loss of epithelial properties due to culture, preventing barrier formation. This study shows that the optimal LMC passage range is between passages two and five for experimentation, as past this range showed cell properties consistent with EMT at the higher passages.
Jet energy calibration with deep learning as a Kubeflow pipeline
Authors: Holmberg Daniel , Golubovic Dejan , Kirschenmann Henning
Published: April 2023

Precise measurements of the energy of jets emerging from particle collisions at the LHC are essential for a vast majority of physics searches at the CMS experiment. In this study, we leverage well-established deep learning models for point clouds and CMS open data to improve the energy calibration of particle jets. To enable production-ready machine learning based jet energy calibration an end-to-end pipeline is built on the Kubeflow cloud platform. The pipeline allowed us to scale up our hyperparameter tuning experiments on cloud resources, and serve optimal models as REST endpoints. We present the results of the parameter tuning process and analyze the performance of the served models in terms of inference throughput, providing insights for future work in this direction. The study also demonstrates improvements in both flavor dependence and resolution of the energy response when compared to the standard jet energy corrections baseline.
Atrial Fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation
Authors: Lamy Jérôme , Taoutel Roy , Chamoun Romy , Akar Joseph , Niederer Steven , Mojibian Hamid , Huber Steffen , Baldassarre Lauren A. , Meadows Judith , Peters Dana C.
Published: April 2023

Aims: A relationship between left atrial strain and pressure has been demonstrated in many studies, but not in an atrial fibrillation (AF) cohort. In this work, we hypothesized that elevated left atrial (LA) tissue fibrosis might mediate and confound the LA strain vs. pressure relationship, resulting instead in a relationship between LA fibrosis and stiffness index (mean pressure/ LA reservoir strain).
Methods and Results: Sixty-seven patients with AF underwent a standard cardiac MR exam including long-axis cine views (2 and 4-ch) and a free-breathing high resolution three-dimensional late gadolinium enhancement (LGE) of the atrium (N=41), within 30 days prior to AF ablation, at which procedure invasive mean left atrial pressure (LAP) was measured. LV and LA Volumes, EF, and comprehensive analysis of LA strains (strain and strain rates and strain timings during the atrial reservoir, conduit and active phases) were measured and LA fibrosis content (LGE (ml)) was assessed from 3D LGE volumes. LA LGE was well correlated to atrial stiffness index (LA mean pressure/ LA reservoir strain) overall (R=0.59, p<0.001), and among patient subgroups. Pressure was only correlated to maximal LA volume (R=0.32) and the time to peak reservoir strain rate (R=0.32), among all functional measurements. LA reservoir strain was strongly correlated with LAEF (R=0.95, p<0.001) and LA minimum volume (r=0.82, p<0.001).
Conclusion: In our AF cohort, pressure is correlated to maximum LA volume and time to peak reservoir strain. LA LGE is a strong marker of stiffness.
Assessment of metric accuracy on data acquisition using point cloud: an application to the José de Alencar Theater
Authors: FIDELES Bruna Tayna Macedo , MESQUITA Esequiel Fernandes Teixeira , MOREIRA Eugênio , VIEIRA Mylene Melo
Published: April 2023

The data acquisition process is an important step in capturing information, especially when it comes to historical heritage documentation, these buildings often have complex structures and little collection, which makes the geometric survey process by the traditional way even more difficult. Currently studies have been conducted using 3D terrestrial laser scanner (TLS) as a capture of geometric information in order to generate point clouds and serve as a basis for analysis, including using BIM and facilitate this documentation process. The paper was developed from a theoretical basis on the subject and application, performing a metric evaluation comparing existing point cloud and 2D surveys, in order to generate a database and propose a method to improve dimensional inspections through point clouds in historic buildings, where it was possible to note some differences in shape and measurement between the two surveys. The study was validated on the metal façade of the José de Alencar Theater.