bluuebunny/crossref_metadata_2025 huggingface dataset:
Korean Medicine Treatment for Anterior Inferior Cerebellar Artery Infarction: A Case Report
Authors: Shin Joo-eun , Kang Jie-yoon , Yang Ji-hae , Won Seo-young , Yoo Ho-ryong , Kim Yoon-sik , Seol In-chan
Published: June 2022

Objective: The aim of this study is to report the effectiveness of Korean medicine for a patient with dizziness following anterior inferior cerebellar artery infarction.Methods: The patient was treated with traditional Korean methods including acupuncture, herbal therapy, moxibustion, and vestibular rehabilitation exercise during an admission period of seven days. The patient’s dizziness was assessed using a numeric rating scale (NRS) and the Korean Dizziness Handicap Inventory (K-DHI), Korean Activities-specific Balance Confidence (K-ABC), Korean Vestibular Disorders Activities of Daily Living (K-VADL), the modified Rankin scale (mRS), and the Korean version of the Modified Barthel Index (K-MBI).Results: After seven days of combined treatment with traditional methods and vestibular rehabilitation, the patient’s dizziness was reduced from NRS 6-7 to NRS 2. In addition, K-DHI decreased from 84 to 22; K-ABC improved from 52% to 78.125%; K-VADL reduced from 175 to 37; the mRS score changed from 4 to 1; and the K-MBI score increased from 86 to 98. No adverse events were observed during treatment.Conclusion: This study suggests that combined therapy of Korean medicine and vestibular rehabilitation can be effective treatment for anterior inferior cerebellar artery infarction patients.
A Case Report of Nonalcoholic Fatty Liver Disease with Obesity and Dyslipidemia
Authors: Kim Eujin , Hwang Cho-Hyun , Lee Juyoung , Jang Eungyeong , Kim Youngchul , Lee Jang-Hoon
Published: June 2022

Objectives: This study aims to report the clinical efficacy of Korean medical treatment of a patient with nonalcoholic fatty liver disease accompanied by obesity and dyslipidemia.Methods: A 52-year-old man with nonalcoholic fatty liver disease, obesity, and dyslipidemia was treated with Saenggangunbi-tang extract from November 3, 2021 to January 8, 2022. During the treatment period, the patient also undertook exercise and maintained a hypocaloric diet to reduce body weight. Changes were observed in the patient’s symptoms, laboratory findings, such as liver enzymes and lipid profiles, and bioelectrical impedance analyzer results.Results: After taking Saenggangunbi-tang extract for approximately two months, with concomitant adjustments to exercise and diet, the serum levels of liver enzymes and triglyceride were decreased and the patient’s body weight, body mass index, hepatic steatosis index, and visceral fat area were also reduced. In addition, symptoms including fatigue and dyspepsia improved.Conclusion: This study suggests that Saenggangunbi-tang extract with exercise and a regulated diet could be a helpful treatment strategy for managing nonalcoholic fatty liver disease with metabolic disorders.
ÜNİVERSİTE ÖĞRENCİLERİNİN EGZERSİZ BAĞIMLILIK DÜZEYLERİNİN İNCELENMESİ
Authors: ÇİNGÖZ Yunus Emre , MAVİBAŞ Muhammed
Published: June 2022

Araştırmanın amacı üniversitelerin farklı birimlerinde öğrenim gören üniversite öğrencilerinin egzersiz bağımlılık düzeylerinin incelemektedir.
Araştırmaya 10 farklı fakültede ve yüksekokulda öğrenim gören toplamda 208’i erkek 296’sı kadın olmak üzere 504 kişi katılmıştır. Araştırmada tarama yöntemi kullanılmıştır. Araştırmada veri toplama aracı olarak “Kişisel Bilgi Formu” ve “Egzersiz Bağımlılığı Ölçeği” kullanılmıştır. Elde edilen verilerin analiz işlemlerinde, katılımcıların demografik özelliklerini belirlemek için frekans analizi, uygulanmıştır. Verilerin dağılımının normalliğini test etmek için Skewness ve Kurtosis Testi yapılarak dağılımın -1,5 ile 1,5 arasında olduğu tespit edilmiştir. Verilerin normal dağılım aralığında olmasından dolayı parametrik testler uygulanmıştır.
Sonuç olarak katılımcıların öğrenim gördükleri fakülte/yüksekokula göre egzersiz bağımlılıklarının karşılaştırılması sonucunda, gruplar arasında anlamlı farklılıklara rastlanmıştır (p<0,05). Katılımcıların egzersiz yapma durumlarına göre egzersiz bağımlılıklarının karşılaştırılmasında gruplar arasında anlamlı farklılıklara rastlanmıştır (p<0,05). Katılımcıların günlük egzersiz sürelerine göre egzersiz bağımlıklarının karşılaştırılması sonucunda, gruplar arasında anlamlı farklılıklara rastlanmıştır (p<0,05).
Privātautonomijas principa atvasināšana no tiesiskas un demokrātiskas valsts pamatnormas un principā ietilpstošās personas tiesības īstenot materiāltiesiskos prasījumus arī tikai daļā kā tiesiskas un demokrātiskas valsts izpausme
Authors: Odiņš Reinis
Published: June 2022

The author reviews the origins of the principle of the private autonomy in the framework of the basic norm (Grundnorm) concept. It is the view of the author that the private autonomy is derived from the fundamental norm of a democratic state and of the rule of law (Rechtsstaat). The principle of private autonomy is recognised to not only have a material aspect, but also a procedural aspect, and therefore it contains the rights of a person to enforce substantive claim also in part only. These rights are a manifestation of a state acting under the fundamental norm of the rule of law and of democracy.
Savstarpējo saskaņošanas procedūru institūta ekskluzivitāte nodokļu strīdu risināšanā
Authors: Ansons Krists
Published: June 2022

The essence of mutual agreement procedure institute in practical application has been ambiguous. The topic has become increasingly relevant, as more taxpayers elect to use this procedure. Ever since the previous paper, there have been many actions taken by the state in order to increase the impact of legal certainty principle. Here, the author will address defining mutual agreement procedure institute with a focus on clearing any confusion between the institute and other tools for eliminating double taxation.
Mans Ķīnas stāsts
Authors: Pildegovičs Pēteris
Published: June 2022

Grāmatas autors Pēteris Pildegovičs šai vēstījumā, kas uzrakstīts dienasgrāmatas formā, dalās ar lasītāju savos vērojumos, kas radušies, veicot pirmā latviešu diplomāta pienākumus Ķīnā, kā arī stāsta par saviem iespaidiem, kas gūti, strādājot “Sjiņhua” aģentūrā, kur līdz šim bijis vienīgais darbinieks no mūsu valsts. Autors iepazīstina lasītāju arī ar pieredzēto lielajos ceļojumos Ķīnā, bieži atsaucoties uz neskaitāmām sarunām ar visu paaudžu un jebkura sociālā slāņa ķīniešiem.
For the Good of Russia
Authors: Gridnev V. P.
Published: June 2022

The relevance of the topic is due to the fact that in modern conditions the relevance of the topic is due to the fact that in modern conditions the role and importance of patriotic education of the younger generation is increasing. Youth is the future of the country and is the barometer of society. The processes that are taking place in the country and around the world are confirmation that young people want to actively participate in the political life of the country, increasing its rating in the international arena. And in this case, history presents an example of the service of faith and truth to the Russian state by Empress Catherine the Great, who set the main goal to revive the power of the Russian Empire and improve the life of the country’s population. Ekaterina, upon taking office, was engaged in reforming the system of public administration, carrying out customs and monetary reforms, increasing the territory of the Russian state, increasing the population of the country, actively counteracting bribery, educating the younger generation, preparing “a new breed or new fathers and mothers, morally perfect”.
Oil Production and Carbon Emissions: Spline Analysis of Relationships
Authors: Ilyasov R. H. , Plotnikov V. A.
Published: June 2022

Obviously, the dynamics of carbon dioxide emissions depends on the volume and structure of consumption of primary energy resources in the economy. The world’s energy consumption shows a growth trend temporarily interrupted during times of economic crisis. The most noticeable decrease in energy consumption in modern history occurred in 2020, which was due to a decline in business activity in the world due to the COVID-19 pandemic. This caused a decrease in carbon emissions (by more than 6% compared to 2019). In the structure of primary energy sources, the largest reduction was in oil consumption. The paper examines the impact of economic crises on the evolution of the mutual link between the dynamics of oil production and carbon dioxide emissions in the world. To detect correlations in local time regions, it is proposed to interpolate process dynamics with cubic splines. Using this toolkit avoids the limitations of classical econometrics on the length of time series. The differentiability of the built spline models allowed us to move on to identifying and analyzing latent correlations in fluctuations in the instantaneous growth rate of oil production volumes and carbon emissions.
O PROGRAMA DE AQUISIÇÃO DE ALIMENTOS E SUAS CONTRIBUIÇÕES PARA SEGURANÇA ALIMENTAR E NUTRICIONAL NA COMUNIDADE DE PLANALTO RURAL NO NORTE DE MINAS GERAIS
Authors: Oliveira Rony Enderson , Paes Silvia Regina , Azevedo Célia Lopes
Published: June 2022

Este artigo tem como objetivo refletir como o Programa de Aquisição Alimentos/PAA, tem contribuído para criação e acesso a novos mercados e sua influência na segurança alimentar e nutricional dos agricultores familiares da comunidade de Planalto Rural em Minas Gerais. Para além da produção e venda o PAA também garantiu melhora na alimentação e segurança alimentar e nutricional aos moradores da comunidade, visto que a variedade que foi implementada nas hortas reflete diretamente na mesa do agricultor. A metodologia do trabalho se baseou em um estudo de caso na comunidade de Planalto Rural, foi utilizada a pesquisa qualitativa. A partir da análise dos dados, identificamos que o PAA foi responsável pela diversificação das hortas nas propriedades e refletiu diretametne na segurança alimentar e nutricional dos moradores.
O ESPECULAR E O ESCÓPICO - UMA RESENHA DE CENÁRIOS DO ESPAÇO URBANO
Authors: F. Rodrigues Luiz Augusto
Published: June 2022

Resenha do livro Cenários do espaço urbano, de Maria Alice Nunes Costa.
FAKE NEWS E SUAS ABORDAGENS NO BRASIL:
Authors: Schlegel Rogério , Freitas Amanda
Published: June 2022

Levantamentos bibliográficos em artigos internacionais apontam que a maioria das pesquisas sobre fake news tem sido desenvolvida pelas áreas de medicina e comunicação, por meio principalmente de métodos quantitativos, com insuficiência em pesquisas das ciências sociais e humanas, refletindo sobre dimensões políticas, impactos eleitorais e sobre a democracia. Este estudo desenvolve revisão sistemática, adotando procedimentos explícitos e replicáveis, na busca de artigos depois analisados substantivamente para descrever temporalidade, área do conhecimento, objetivo da pesquisa, métodos utilizados e outras características de interesse. Foram mapeados artigos publicados em português ou por brasileiros, até agosto de 2020, em periódicos presentes na base internacional DOAJ (Directory of Open Access Journals), em que a expressão "fake news" constasse no título, no resumo e/ou nas palavras-chave. A busca resultou em 68 artigos, com concentração nas áreas de ciências sociais, comunicação, saúde e educação. Predominaram trabalhos com descrição de características de notícias falsas, formas de combatê-las e discussões conceituais sobre a desinformação e seus efeitos. Abordagens qualitativas foram mais frequentes que quantitativas. A pandemia de Covid-19 declarada em 2020 impulsionou os estudos sobre o tema mais do que as eleições presidenciais de 2018. O contraste com a produção internacional sugere espaço para mais estudos futuros que sejam comparativos, quantitativos, com maior rigor metodológico nas análises qualitativas e com foco na prevalência das fake news.
A AUTONOMIA DO DIREITO PRÓPRIO DOS POVOS INDÍGENAS
Authors: Cavalcante Filho Raimundo Paulino , Da Silva Fragale Filho Roberto
Published: June 2022

Este artigo cuida da temática relativa à autonomia da ordem jurídica indígena sob a perspectiva latino-americana, especialmente em colisão com a ordem jurídica estatal, inclusive com os direitos fundamentais definidos pela ordem jurídica interna e/ou pelas normas internacionais de direitos humanos. Formula-se no plano do direito constitucional latino-americano, sobretudo do transfronteiriço território amazônico, a proposição da autonomia da ordem jurídica indígena enquanto decorrência da ideia de estado plurinacional, mormente diante da confrontação com o modelo de estado-nação. Procura-se demonstrar a possibilidade da autonomia jurídica extraestatal de coletividade nativa com fundamento na concepção doutrinária do transconstitucionalismo unilateral de tolerância, com realce da concepção da autodeterminação, do multiculturalismo e da jusdiversidade.
GOVERNANDO ATRAVÉS DO CRIME:
Authors: Pessoa Sara Araujo , Leal Jackson da Silva , Rosa Alex , Costamilam Amanda
Published: June 2022

O presente artigo trata-se de uma análise sobre os elementos que, durante o séc. XX, nos Estados Unidos da América (EUA), ensejaram e compuseram uma nova lógica governamental centrada em pautas punitivas vinculadas à política criminal. Essa mudança, constituinte do que Simon (2009) chama por “governo através do crime”, contou com os esforços da mídia em moldar e reforçar o deslocamento da questão criminal para o senso comum. Esse “giro punitivo” (SOZZO, 2012) passa também a reorganizar a relação entre povo, pautas e representações políticas, desembocando em políticas criminais de tolerância zero, de criminalização das drogas, encarceramento da população negra, e na formação do que se denominou como complexo industrial prisional (DAVIS,2018). Orientando-se pelo método indutivo e investigando via revisão bibliográfica, a pesquisa esclareceu as conjunturas que compuseram a lógica governamental centrada pela questão criminal e que não se restringe à realidade norte americana.
MEDIAÇÕES NA AUSTRÁLIA E BRASIL
Authors: De Rezende Alvim Joaquim Leonel , Vianna Veras Cristiana
Published: June 2022

Nosso artigo propõe uma leitura da mediação relacionada ao acesso à justiça e à ética jurídica para, a partir da relação com essas duas variáveis, apresentar como essa forma de abordagem estaria sendo percebida pelos estudantes de direito em dois contextos diferenciados (Austrália e Brasil) no universo das suas representações. Num primeiro momento desenvolvemos as motivações dessa escolha em termos interacionais, teóricos e conceituais. Num segundo momento fazemos uma apresentação e interpretação de dados ilustrativos dos sentidos e significados da mediação para os alunos dos universos pesquisados que indicam, dentre diferentes pistas de análise, para uma mediação que aparece, por um lado, nas representações dos alunos no Brasil, como estranha ao funcionamento do judiciário brasileiro e que, por outro lado, nas representações dos alunos na Austrália, aparece incorporada e familiar (em oposição ao estranhamento) ao funcionamento do judiciário australiano.
Sustainable Development Goals (Sdgs): Kehidupan Sehat Dan Sejahtera Dalam Penanggulangan Covid-19 Di Daerah Semarang
Authors: Bintang Bintang , Oktaviani Amelia Putri Vera , Annura Malsa Syifa
Published: June 2022

Pandemi COVID -19 telah memberikan dampak pada bidang kesehatan dan perekonomian di berbagai negara termasuk Indonesia. Memasuki era Sustainable Development Goals (SDG’s) yang merupakan konsep lanjutan dari MDG’s kehidupan sehat dan sejahtera masih menjadi suatu permasalahan yang belum diselesaikan. Kasus yang terjadi diantaranya yaitu: upaya penurunan angka kematian ibu (AKI) dan angka kematian bayi (AKB), pengendalian penyakit HIV/AIDS, TB, Malaria serta peningkatan akses kesehatan reproduksi (termasuk KB), dan beberapa hal baru yang menjadi perhatian, yaitu: Kematian akibat penyakit tidak menular (PTM), Penyalahgunaan narkotika dan alkohol, Kematian dan cedera akibat kecelakaan lalu lintas, Universal Health Coverage (program yang memastikan masyarakat memiliki akses untuk mendapatkan pelayanan kesehatan tanpa harus mengahadapi kesulitan finansial. Hal ini ditunjang dengan pelayanan fasilitas kesehatan yang berkualitas), Kontaminasi dan polusi air, udara dan tanah, serta penanganan krisis dan kegawatdaruratan. Berbagai upaya yang telah dilakukan oleh pemerintah melalui program-program tertentu dalam menanggulangi masalah kesehatan terutama pada kasus pandemi COVID-19 yang terjadi pada saat ini.
Pendampingan Keluarga Sadar Gizi Seimbang di Desa Dwi Karya Bhakti, Kecamatan Pelepat, Kabupaten Bungo
Authors: Perdana Silvia Mawarti , Asparian Asparian , Lia Nurdini
Published: June 2022

Indonesia is still facing the Covid-19 pandemic, as well as Jambi Province. Dwi Karya Bhakti Village is one of the villages located in Pelepat District, Bungo Regency, Jambi Province and become community health target area of UPT Puskesmas (community health centre) Rantau Keloyang. Prevention of Covid-19 can be done by implementing balanced nutrition behavior in the community which consists of four pillars of balanced nutrition, namely: eating variety of foods, clean and healthy lifestyle, physical activity, and monitoring normal body weight (BB). This community service aimed to increase PKK (Family Welfare Empowerment) cadres’s knowledge and skill as part of implementing family balanced nutrition behavior. These projects include: focus group discussions related to community nutrition problems, causes, and solutions by involving puskesmas, PKK cadres, and village governments; and also education and practice of balanced nutrition to 15 PKK cadres. The results of this community service showed that there is difference in the knowledge of PKK cadres in the application of balanced nutrition behavior compared to before participating in mentoring (test score from 84.7 to 93,3). The implementation of balanced nutrition behavior in the family need to be continued as one of the efforts to prevent Covid-19.
The impact of internal financial determinants on the financial performance of listed mineral firms on the Vietnam Stock Exchange
Authors: Nguyen Hoan , Do Duc Tai , Nguyen Thi Hoai Thu , Nguyen Thi Thu Thuy , Tran Manh Dung , Nguyen Thu Thuy , Pham Van Hieu , Nguyen Thi Thao
Published: June 2022

This study aims to investigate the impact of internal financial factors on the financial performance of mineral firms listed on the Vietnam Stock Exchange. The research uses quantitative and qualitative methods to process the data collected. The results reveal that determinants of internal financial factors, including solvency, have a negative correlation with return on sales (ROS); firm growth rate (RG) has a positive correlation with ROS; capital structure influences the return on equity (ROE) positively, and capital structure negatively affects ROE; capital structure and DR have a negative impact on return on assets (ROA); current assets structure have a positive correlation with the ROA; CR has a negative impact on ROA; while firm RG and age have a positive correlation with ROA; the remaining determinants do not influence financial performance. Nhung, Daphné, and Huyen (2021) concluded that two variables consisting of total assets turnover ratio (ATR) and growth in sales significantly influence financial performance (FP) when it is measured by return on equity (ROE) or return on sales (ROS). However, this impact level of internal financial determinants is different. Finally, some suggestions are shown to enhance the financial performance of listed mineral firms in Vietnam
TINJAUAN PRINSIP GOOD GOVERNANCE DAN PERSPEKTIF ISLAM DALAM OPERASIONAL LEMBAGA ZIS
Authors: Iswari Putu Widhi , Rosyid Maskur
Published: June 2022

The Zakat and Alms (ZIS) Institution, as a non-profit organization are required to work professionally and proportionally. The complex of challenges in managing operational from other institution and also satisfaction as a target for all the stakeholders. Neglecting and ignoring of these challenges can stimulate the stagnation and less of trust from all the component in this institution. Therefore, alternative solutions are needed in order to minimize the negative possibilities. Through of this review of study, that using the perspective of principles Good Governance and Islamic perspectives, this paper intends to discuss both of the approaches as an input for the ZIS institution in Higher Education Institution within their operating system all the business process run efficient and effective. Nine principles of Good Governance within the Islamic principles are necessary to apply and to implement a good way.Lembaga Zakat, Infak dan Sedekah (ZIS), sebagai lembaga non-profit, dituntut untuk bekerja secara profesional dan proporsional. Tuntutan semacam itu muncul dibarengi dengan tantangan zaman yang semakin kompleks. Menafikan tantangan berakibat pada kemandegan dan kehilangan kepercayaan dari stakeholders. Oleh karenanya, dibutuhkan solusi alternative dalam rangka menyiasati akibat negative tersebut. Melalui kajian pustaka, menggunakan perspektif prinsip-prinsip good governance dan prinsip Islam, tulisan ini hendak membincang kedua pendekatan tersebut sebagai alat baca pada tata kelola Lembaga ZIS pada perguruan tinggi. Sembilan prinsip good governance yang sejalan dengan prinsip Islam, menjadi mutlak untuk diterapkan pada tata kelola Lembaga ZIS di perguruan tinggi.
MANAJAMEN ISTIBDAL ATAS ASET WAKAF SEBAGAI PEMBANGUNAN EKONOMI
Authors: Arifin Nur Rachmat , Muhtadi Ridan , Aziz Abd
Published: June 2022

AbstractThis paper is to formulate a model through which Istibdal management can increase waqf assets more productively and as economic development. This model is built on the basis of understanding the concept of waqf, learning from past and present waqf institutions and addressing the issue of waqf in Indonesia. This research uses descriptive qualitative research with the library research method. This study uses secondary data from the Indonesian Waqf Board (BWI), books, journals, bulletins, government reports and websites. The whole process can be managed by a waqf institution as a waqf nazdir which collaborates to be supervised by BWI (Indonesian Waqf Agency) in using waqf assets in accordance with syaraih principles and as economic development. This research shows how Istibdal management can assist the Government of Indonesia in economic development with mixed public goods and public goods. This implies an alternative source of funding for Development. The application of the concept of waqf can learn and adapt from the model developed in this paper. This paper attempts to revive the function of waqf as a provider of diverse public goods and public goods from Islamic history. Incidentally, this paper also introduces waqf as economic development in Indonesia.Keywords: Istibdal Waqf, Management, Utilization.
Wooden remains found at Daskyleion and their anatomical examination
Authors: KASAR Özgün , AKKEMİK Ünal , İREN Kaan
Published: June 2022

The wooden remains found in T6 and T7 tumuli and “Three-Room Building” complex of Acrodaskyleion are the subject of the study. These samples were found in the sockets of copper alloy arrowheads in T6 Tumulus. Also, another sample was found in a bullet covered tenon on a marble block in the T7 Tumulus. Anatomical examination on wooden samples, the arrows was made of poplar/willow. The wooden specimen found in the tenon belongs to the Black pine, the genera/species identified are the common trees in the region. Black pine is the main forest tree, which have a wide natural distribution area, and poplar/willow grow through the rivers in the region. As conclusion, the types of wood processed were selected according to its function. The tenon was made by black pine which is more resistant to external deteriorations. The wooden part of the arrows is made of low density and flexible poplar/willow wood.
AN EVALUATION ON THE ISLAMIC PERIOD GLAZED CERAMICS IN THE VAN MUSEUM
Authors: BAŞ Gülsen , YILMAZ Güler
Published: June 2022

Abstract

In this study, bowl, plate, bowls, tray, inkwells, medicine containers (albarello), jar and jugs produced with monochromatic glazed, sgraffito and underglaze decoration techniques belonging to the Islamic period in the Van Museum are discussed. Very few examples among the works examined were unearthed during the excavations of Van Castle and the Old City of Van. A large part of the ceramics was brought to the museum through purchases and grants. The works belonging to the Seljuk, Principalities, Ottoman, Safavid and Qajar periods were examined in terms of material, technique, form and decoration, and the similarities and differences between the periods were emphasized. The ceramics grouped according to their techniques were evaluated according to their dough, form and ornamental characteristics and a dating proposal was made. It is observed that the examined containers exhibit features close to the stylistic lines of the periods they belong to, with their qualities. It is thought that inkwells and medicine containers from monochrome glazed containers have a stylistic appearance from the 12th-13th century, while bowls, jars, trays and jugs have a continuous stylistic appearance from the 17th to the 20th centuries. It has been observed that the ceramics in the Sgraffito technique have some characteristics that can be dated to the 13th-14th century, and the underglaze decoration samples to the 15-20th century.
Elongation arrest blocking primers enhance parasite detection in 18S rRNA metabarcoding study of Mesonauta festivus gut eukaryotic communities.
Authors: Leroux Nicolas , Bouslama Sidki , Sylvain François-Étienne , Val Adalberto , Derome Nicolas
Published: June 2022

The study of the eukaryotic fraction of the microbiota using a
metabarcoding approach is usually hindered by the high host to
eukaryotic microbiota DNA ratio in samples. Indeed, the 18S rRNA gene is
very similar for both the host and its eukaryotic communities, leading
to a preferential amplification of the predominant host DNA when using
universal primers. Multiple approaches have been developed to reduce
host DNA amplification. One method is based on elongation arrest
blocking primers, oligonucleotides modified with a C3 Spacer that stops
the advancement of the DNA polymerase at non-conserved regions of a
target gene. In this paper, we successfully developed and tested
species-specific elongation arrest blocking primers to block the Flag
cichlid, Mesonauta festivus, 18S rRNA SSU. Our elongation arrest
blocking primers significantly reduced the amount of host DNA in samples
by 66 %. In addition to reducing the amount of sequencing wasted, the
blocking primers increased the detectability of potentially dangerous
parasitic taxa in fish gut, highlighting the potential of the method for
parasitic screening. For instance, we discovered a case of infection by
the parasitic ciliate Nyctotherus sp. Also, we detected the presence of
a parasitic Trematode and an Amoebae, collected compelling data on the
species feeding habits and obtained data on the commensal eukaryotic
diversity present in M. festivus gut. While our data support the
possibility of achieving a complete inhibition of host DNA amplification
using elongation arrest blocking primers, more research is still
required. Still, there is a need for the development and additional
testing of protocols to study the eukaryotic diversity present in fish
gut, a slow-growing field of study in comparison to its prokaryotic
counterpart.
Metastatic and multiply relapsed SDH deficient GIST and paraganglioma displays clinical response to combined Poly ADP-Ribose Polymerase inhibition and Temozolomide
Authors: Vasquez Juan , Singh Charu , Bindra Ranjit , Glazer Peter M. , Pashankar Farzana
Published: June 2022

Pediatric GIST (gastrointestinal stromal tumors) are mostly KIT/
PDGFRA-WT and harbor mutations in SDH (succinate dehydrogenase), making
them TKI (tyrosine kinase inhibitor) resistant due to the absence of
gain-of-function tyrosine kinase mutations. Due to rarity of GIST in
children, there have been few clinical trials available for patients
with advanced disease, resulting in limited treatment options and a lack
of pediatric-specific consensus guidelines. Here, we report the case of
a patient with progressive, metastatic SDHB-mutant GIST that displayed a
significant clinical response with a combination of Olaparib and TMZ
(temozolomide).
Not out of the Mediterranean: Atlantic populations of the gorgonian Paramuricea clavata are a separate sister species under further lineage diversification
Authors: Coelho Márcio , Pearson Gareth , Boavida Joana , Paulo Diogo , Aurelle Didier , Arnaud-Haond Sophie , Gómez-Gras Daniel , Bensoussan Nathaniel , López-Sendino Paula , Cerrano Carlo , Kipson Silvija , Bakran-Petricioli Tatjana , Ferretti Eliana , Linares Cristina , Garrabou Joaquim , Serrão Ester , Ledoux Jean-Baptiste
Published: June 2022

The accurate delimitation of species boundaries in non-bilaterian marine
taxa is notoriously difficult, with consequences for many studies in
ecology and evolution. Anthozoans are a diverse group of key structural
organisms worldwide, but the lack of reliable morphological characters
and informative genetic markers hampers our ability to understand
species diversification. We investigated population differentiation and
species limits in Atlantic (Iberian Peninsula) and Mediterranean
lineages of the octocoral genus Paramuricea previously identified as P.
clavata. We used a diverse set of molecular markers (microsatellites,
RNA-seq derived single-copy orthologues [SCO] and mt-mutS
[mitochondria]) at 49 locations. Clear segregation of Atlantic and
Mediterranean lineages was found with all markers. Species-tree
estimations based on SCO strongly supported these two clades as
distinct, recently diverged sister species with incomplete lineage
sorting, P. cf. grayi and P. clavata, respectively. Furthermore, a
second putative (or ongoing) speciation event was detected in the
Atlantic between two P. cf. grayi colour morphotypes (yellow and purple)
using SCO and supported by microsatellites. While segregating P. cf.
grayi lineages showed considerable geographic structure, dominating
circalittoral communities in southern (yellow) and western (purple)
Portugal, their occurrence in sympatry at some localities suggests a
degree of reproductive isolation. Overall, our results show that
previous molecular and morphological studies have underestimated species
diversity in Paramuricea occurring in the Iberian Peninsula, which has
important implications for conservation planning. Finally, our findings
validate the usefulness of phylotranscriptomics for resolving
evolutionary relationships in octocorals.
A rare case of acrocallosal syndrome in a neonate with a history of maternal exposure to cosmetics-related chemicals
Authors: Sarmadian Roham , Gilani Abolfazl , Biglari Habibe Nejad , Vasigh Mahtab
Published: June 2022

The usual features of the acrocallosal syndrome (ACLS) are agenesis of
the corpus callosum, mental retardation, prominent craniofacial
deformities, and specific digital abnormalities. We discuss the case of
a neonate with ACLS-consistent characteristics. The occurrence of this
syndrome may have been caused by maternal exposure to cosmetics-related
substances during pregnancy.
Survival of four different radical hysterectomy approaches for early-stage cervical cancer: a retrospective study
Authors: Zhang Nina , Jin Xiangshu , Yang Wen , Gu Chenglei , Li Li'an , Fan Wensheng , Meng Yuanguang
Published: June 2022

Objective This study compares survival of four different surgical
approaches including ARH, LRH, RRH and VRH for early-stage cervical
cancer in order to define the best effects and survivals for patients.
Design Retrospective study. Setting The First Medical Center of the PLA
General Hospital. Population 238 women diagnosed early-stage cervical
cancer between January 2013 and December 2017 and followed up until
September 2020. Methods All patients with early-stage cervical cancer
were retrospective collected in the first medical center of the PLA
general hospital. Disease free survival (DFS) and overall survival (OS)
were calculated using Kaplan-Meier’s method, and survival curves were
compared using log-rank test. Main outcome measures Outcomes were the
comparison of patients’ DFS and OS between the four different radical
hysterectomy approaches. Results The intraoperative blood loss and
postoperative exhaust time of LRH, RRH and VRH groups are better than
that in ARH group. The total 5-year OS was significant difference among
the four groups. However, the difference of 5-year DFS was not
statistically significant among the four groups. Furthermore, patients
with early-stage cervical cancer had a significantly better DFS and OS
in ARH and RRH groups than that in LRH and VRH groups. Conclusions This
retrospective study demonstrated that both ARH and RRH obtained higher
rate of 5-year DFS and 5-year OS compared with LRH and VRH for
early-stage cervical cancer, and the survival outcomes between ARH and
RRH were similar. Keywords Cervical cancer, ARH, LRH, RRH, VRH,
survival.
Adsorptin of bendomustine anti-cancer drug on Al/B-N/P nanocages: A comparative DFT study
Authors: Madadi Mahani , Behjatmanesh-Ardekani Reza , Yosefelahi Roya
Published: June 2022

Anti-cancer drug delivery based on nanocages is important step in drug development process due to reducing side effects and drug-releasing near the tumor cell. We have studied the interaction of the bendamustine anti-cancer drug with the Al/B-N/P nanocages with utilization density functional theory (DFT) approach both in gas and water phases at the B3LYP/6-31G (d,p) level of theory. Results show that the nanocages quantum parameters were somewhat varied by the adsorption of the bendamustine drug. The bendamustine drug operates as an electrons donor and can adsorb in the site of the electron?s acceptor of nanocages. The changes in Gibbs energy correspond to a chemisorption in both phases. The results indicated that the bond between studied nanocages and bendamustine is covalent. However, all studied nanocages may be favorable candidates for detecting the bendamustine drug. Yet, pristine B12P12 and B12N12 nanocages appeared to be more suitable for drug delivery than Al12P12 and Al12N12 based on their recovery times.
NRF2 Genetic Polymorphism Modifies the Association of Plasma Selenium Levels With Incident Coronary Heart Disease Among Individuals With Type 2 Diabetes
Authors: Jia Chengyong , Wang Ruixin , Long Tengfei , Xu Yali , Zhang Ying , Peng Rong , Zhang Xiaomin , Guo Huan , Yang Handong , Wu Tangchun , He Meian
Published: June 2022

Plasma selenium and NRF2 promoter variants (e.g., rs6721961) are associated with cardiovascular disease risk in the general population. However, epidemiological evidence on the interaction between plasma selenium and NRF2 genetic susceptibility in relation to incident coronary heart disease (CHD) risk remains scarce, especially among individuals with type 2 diabetes (T2D). Thus, we examined whether rs6721961 in the NRF2 gene might modify the association between plasma selenium levels and incident CHD risk among people with T2D. During a mean (SD) follow-up period of 6.90 (2.96) years, 798 incident CHD cases were identified among 2,251 T2D cases. Risk-allele carriers of rs6721961 had a higher risk of incident CHD among people with T2D (adjusted hazard ratio [HR] 1.17; 95% CI 1.02–1.35) versus nonrisk-allele carriers. Each 22.8-μg/L increase in plasma selenium levels was associated with a reduced risk of incident CHD among risk-allele carriers with T2D (HR 0.80; 95% CI 0.71–0.89), whereas no association was found in those without risk alleles (P for interaction = 0.004), indicating that the NRF2 promoter polymorphism might modify the association between plasma selenium levels and incident CHD risk among people with T2D. Our study findings suggest redox-related genetic variants should be considered to identify populations that might benefit most from selenium supplementation. More mechanistic studies are warranted.
Low-Cost Mine Detector Design Using Magnetic Anomaly Method
Authors: IŞIK Mehmet Fatih , SUİÇMEZ Çağrı , YILMAZ Cemal
Published: June 2022

Buried mines pose great dangers to humans and animals around the world, which means thousands of people die each year from buried mines. Detecting and destroying these mines without harming people is an important issue. Today, these landmines are detected using different methods such as Ground Effect Radar, Electromagnetic induction, Infrared and Nuclear Quadrupole Resonance and active sensors are generally used in most of these methods. Although active sensor-based landmine detectors are often used for performance reasons, they can cause unintentional landmine explosions because they operate with transmitted and reflected signals. On the other hand, there is no such obstacle that can perform better in passive sensor-based landmine detectors depending on the design criteria. Therefore, in this study, a prototype design including passive sensor with magnetic anomaly method has been developed and shown. For the performance analysis of this detector, real landmines are used and the designed system is tested with different distance values in different soil types. The results show that the prototype produced successfully detects different types of landmines, is assertive in its lightness and only 1750 grams with its battery, providing sensitivity as well as advantages such as ease of use and low cost. It also shows the feature of being the first handheld landmine detector based on magnetic anomaly.
PLANOS DE ASSISTÊNCIA AOS DESVALIDOS DAS SECAS NA REGIÃO NORDESTE DO BRASIL (1878-1915)
Authors: Sousa Jose Freitas
Published: June 2022

A implantação de planos de assistência aos desvalidos das secas foi consequência da execução do projeto Pompeu Sinimbú no Ceará, cuja estratégia era equacionar o problema do desequilíbrio econômico entre as regiões Nordeste e Centro-Sul do Brasil entre 1878 e 1959. O projeto se baseava na ideia de realizar o progresso da região Nordeste do Brasil por meio de obras, que empregassem a mão de obra dos retirantes aptos para o trabalho, sob a coordenação dos governos locais ou por meio de órgãos públicos. Por isso, era preciso planejar a organização desses trabalhadores deslocados de seus domicílios e a distribuição de alimentos.
ANALISIS PENDAPATAN DAN FAKTOR – FAKTOR YANG MEMPENGARUHI KEUNTUNGAN USAHATANI BAWANG MERAH DI KECAMATAN GUNUNG ALIP KABUPATEN TANGGAMUS
Authors: Sarwinda Nurul , Arifin Bustanul , Riantini Maya
Published: June 2022

This study aims to analysis income and factors affecting profitability of red onion farming. This research was conducted in Gunung Alip Subdistrict, Tanggamus District.  This study used a survey method, while data were collected by census of 30 red onion farmers in the study area. Data collection was carried out from March to April 2019. The first objective was to find out the income of red onion farming using R-C ratio analysis, while the second objective was to find out the factors affecting the profit of red onion farming using the Cobb-Douglas UOP profit function analysis (Unit Output Price). The results showed that income over cash costs is IDR 63,723,312.16 per planting season/ha and income over total costs is IDR 54,013,048.10 per planting season/ ha.  R/C value of cash costs is 2.51 and R/C of total costs is 2.04, so that red onion farming is profitable.  Factors affecting the profitability of red onion farming are the price of red onion seeds (X1), labor costs (X8), and land size (Z1). Key words: farming, income, red onion, profit.
PENGEMBANGAN INSTRUMEN PENILAIAN “HOTS” DARI BUKU TEMATIK DENGAN MENGGUNAKAN QUIZIZZ DI SEKOLAH DASAR
Authors: Setiani Agus Esti
Published: June 2022

Abstract:. This research is motivated by the importance of developing HOTS-oriented assessments, especially on the dimensions of analyze (C4) and evaluate (C5) thinking processes in 21st century learning. The purpose of this study is to(1)explains the process of developing the "HOTS"-oriented assessment instrument from the thematic book using the Quizizz application in the fourth grade of elementary school,(2)verification the quality of the “HOTS”-oriented assessment instrument from thematic books using the Quizizz application in grade IV Elementary School,(3)verification responses from teacher and student's on the "HOTS"-oriented assessment instrument from the thematic book using the Quizizz application in the fourth grade of elementary school. This research design uses the ADDIE model. Data analysis in this research are descriptive qualitative and descriptive quantitative. The results showed that the quality of the developed product obtained a content validity assessment with a high category from material experts, the reliability of the questions was low, the level of difficulty included 2 difficult questions, 8 medium questions, and 10 easy questions, and had different questions. Based on the results of field trials, a "very positive" response was obtained from teacher and students in using the Quizizz Application for assessment.Keyword: Assessment Instrument, Higher Order Thinking Skill, Thematic, Quizizz Abstrak: Penelitian ini dilatarbelakangi oleh pentingnya pengembangan penilaian berorientasi HOTS khususnya pada dimensi proses berpikir menganalisis (C4) dan mengevaluasi (C5) dalam pembelajaran abad ke-21. Tujuan dari penelitian ini adalah untuk(1)mendeskripsikan proses pengembangan instrumen penilaian  berorientasi “HOTS” dari buku tematik dengan menggunakan aplikasi Quizizz di kelas IV  Sekolah Dasar,(2)memverifikasi kualitas instrumen penilaian  berorientasi “HOTS” dari buku tematik dengan menggunakan aplikasi Quizizz di kelas IV Sekolah Dasar,(3) memverifikasi respon guru dan peserta didik terhadap instrumen penilaian  berorientasi “HOTS” dari buku tematik dengan menggunakan aplikasi Quizizz di kelas IV  Sekolah Dasar. Desain penelitian ini menggunakan model ADDIE. Analisis data dalam penelitian ini yaitu analisis data deskriptif kualitatif dan deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa kualitas produk hasil pengembangan memperoleh penilaian validitas isi dengan kategori tinggi dari ahli materi, reliabilitas soal rendah,tingkat kesukaran meliputi 2 soal sukar, 8 soal sedang, dan 10 soal mudah, serta memiliki daya beda soal . Berdasarkan hasil uji coba lapangan didapatkan respon “sangat positif” dari guru dan peserta didik dalam penggunaan Aplikasi Quizizz untuk  penilaian. Kata Kunci: Instrumen Penilaian, Higher Order Thinking Skill, Tematik, Quizizz
Penerapan Model Pembelajaran Pair Checks untuk Meningkatkan Kemampuan Kerja Sama Siswa pada Tema Daerah Tempat Tinggalku Kelas IV Sekolah Dasar Negeri 014 Sungai Keranji
Authors: Dila Isvadila , - Herlina , - Syarifuddin
Published: June 2022

This study aims to determine the improvement of students' cooperative abilities on the theme of the area where I live through the application of thelearning model pair checks Grade IV State Elementary School 014 Sungai Keranji. This research is motivated by the lack of student collaboration skills because there are still many students who do not help each other in group learning. This research is a classroom action research. The subjects of this study were 1 teacher and 20 students in grade IV of the State Elementary School 014 Sungai Keranji. While the object is the application of thelearning model pair checks and students' collaboration skills. This research was conducted in two cycles and each cycle consisted of two meetings. Data collection techniques using observation and documentation techniques. While the data analysis technique used is descriptive qualitative analysis with percentages. Based on the results of research and data analysis shows that thelearning model pair checks can improve students' cooperative abilities. This can be seen from before the action only reached 43.42% with the Less category. After doing the class action in the first cycle, the students' cooperation ability increased to 70.28% in the Good category. While in the second cycle there was an increase to 90% in the Very Good category. Thus, it can be concluded that the application of thelearning model pair checks can improve students' collaboration skills on the theme of the area where I live in class IV of the 014 Sungai Keranji State Elementary School.
PENGEMBANGAN SOAL MATEMATIKA BERBASIS MACROMEDIA FLASH 8 DI KELAS V SD
Authors: R Selvi Febliani
Published: June 2022

Penelitian ini bertujuan untuk mengembangkan soal matematika berbasis macromedia flash 8 di kelas V SD pada materi operasi hitung pecahan yang valid dan praktis, Metode penelitian ini menggunakan model plomp dengan tiga tahapan yaitu fase pnelitian awal, fase pengembangan atau pembuatan prototipe, dan fase penilaian dengan pengumpulan data melalui observasi, teknik wawancara, dan angket. Analisis data berupa analisis data kualitatif deskriptif dan kuantitatif deskriptif, Produk yang dihasilkan terdiri dari 13 slide pengerjaan soal matematika. Soal matematika berbasis macromedia flash 8 di kelas V SD yang dikembangkan di validasi oleh satu ahli matematika dan satu ahli produk media, untuk menguji kepraktisan peneliti membagikan pertanyaan kepada guru dan peserta didik. Pengembangan soal matematika berbasis macromedia flash 8 sangat valid dengan skor rata-rata 87,05% dengan kategori sangat valid, hasil praktikalitas dari guru 87,49% kategori sangat praktis, dan  90,54% perolehan hasil skor praktikalitas dari peserta didik. Sehingga disimpulkan bahwa pengembangan soal matematika berbasis macromedia flash 8 di kelas V SD dapat digunakan sebagai alat evaluasi pembelajarn matematika.
Upaya Peningkatan Hasil Belajar Siswa Dengan Penerapan Metode Pembelajaran Kooperatif Tipa Make A Macth Pada Materi Fiqh Kelas IV di MI Taufiqiyah Kota Dumai
Authors: Safrianis Safrianis
Published: June 2022

Abstract. Tujuan penelitian ini adalah untuk mendeskripsikan pelaksanaan pembelajaran dan hasil belajar siswa dengan menerapkan metode pembelajaran kooperatif tipe make a match. Penelitian ini merupakan penelitian tindakan kelas (PTK). Subjek penelitian adalah siswa kelas IV B MI Taufiqiyah Kota Dumai dengan matapelajaran Fiqh yang berjumlah 30 orang siswa. Teknik pengumpulan data yang digunakan terdiri dari observasi dan tes. Pada siklus I pelaksanaan pembelajaran diperoleh persentase sebesar 66,7 %, dan pada siklus II 88,9 %. Hasil belajar yang diperoleh siswa pada siklus I diperoleh sebesar 63,3 %, dan pada siklus II 86,7 %. Berdasarkan hasil yang diperoleh, dapat disimpulkan bahwa penerapan metode pembelajaran kooperatif tipe make a match dapat meningkatkan hasil belajar siswa pada materi fiqh.Kata Kunci: Metode Pembelajaran Kooperatif Tipe Make A Match, Hasil Belajar
Rapid Identification of Western Flower Thrips, Frankliniella occidentalis (Thysanoptera: Thripidae) in Shade Houses in Western Cape of South Africa
Authors: Dlamini Thandwa , Assefa Yoseph
Published: June 2022

The western flower thrips (WFT), Frankliniella occidentalis (Pergande) (Thripidae: Thysanoptera), is one of the most economically important pests in shade houses. However, their identification is usually difficult, with them being easily confused with other thrips species. Accurate, rapid and reliable identification of insect pests is a crucial first step in implementing an efficacious management program. In this study the identity of F. occidentalis was verified, using molecular methods using the mtCOI gene sequences. Molecular analysis of thrips specimens collected from chrysanthemums and blueberries in the Western Cape Province, South Africa revealed the presence of Frankliniella. occidentalis and four other thrips species. Two of the five the specimens were F. occidentalis and one of the specimens was identified as Gynaikothrips ficorum. The remaining specimens were identified only to a generic level as Pseudophilothrips sp and to an ordinal level as Thrips sp. Failure to identify the two specimens to specific levels might have resulted from lack of sequences of identified thrips species in the molecular data bases. Considering the speed, specificity as well as sensitivity of the method, mtCOI sequences can be used as a swift and efficient method for western flower thrips identification and detection of new thrips pest invasion.