bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis of Breast Cancer with Strongly Supervised Deep Learning Neural Network
Authors: Gui Haitian , Su Tao , Pang Zhiyong , Jiao Han , Xiong Lang , Jiang Xinhua , Li Li , Wang Zixin
Published: September 2022

The strongly supervised deep convolutional neural network (DCNN) has better performance in assessing breast cancer (BC) because of the more accurate features from the slice-level precise labeling compared with the image-level labeling weakly supervised DCNN. However, manual slice-level precise labeling is time consuming and expensive. In addition, the slice-level diagnosis adopted in the DCNN system is incomplete and defective because of the lack of other slices’ information. In this paper, we studied the impact of the region of interest (ROI) and lesion-level multi-slice diagnosis in the DCNN auxiliary diagnosis system. Firstly, we proposed an improved region-growing algorithm to generate slice-level precise ROI. Secondly, we adopted the average weighting method as the lesion-level diagnosis criteria after exploring four different weighting methods. Finally, we proposed our complete system, which combined the densely connected convolutional network (DenseNet) with the slice-level ROI and the average weighting lesion-level diagnosis after evaluating the performance of five DCNNs. The proposed system achieved an AUC of 0.958, an accuracy of 92.5%, a sensitivity of 95.0%, and a specificity of 90.0%. The experimental results showed that our proposed system had a better performance in BC diagnosis because of the more precise ROI and more complete information of multi-slices.
Non-Invasive Detection of Lithium-Metal Battery Degradation
Authors: Iurilli Pietro , Luppi Luigi , Brivio Claudio
Published: September 2022

The application of Lithium Metal Batteries (LMBs) as secondary cells is still limited due to dendrite degradation mechanisms arising with cycling and responsible for safety risk and early cell failure. Studies to prevent and suppress dendritic growth using state-of-the-art materials are in continuous development. Specific detection techniques can be applied to verify the internal condition of new LMB chemistries through cycling tests. In this work, six non-invasive and BMS-triggerable detection techniques are investigated to anticipate LMB failures and to lay the basis for innovative self-healing mechanisms. The novel methodology is based on: (i) defining detection parameters to track the evolution of cell aging, (ii) defining a detection algorithm and applying it to cycling data, and (iii) validating the algorithm in its capability to detect failure. The proposed methodology is applied to Li||NMC pouch cells. The main outcomes of the work include the characterization results of the tested LMBs under different cycling conditions, the detection techniques performance evaluation, and a sensitivity analysis to identify the most performing parameter and its activation threshold.
Drainage Potential Curves of Single Tapping Point for Bulk Oil–Water Separation in Pipe
Authors: Asaadian Hamidreza , Harstad Sigurd , Stanko Milan
Published: September 2022

In this study, experimental quantification of drainage potential curves for unspiked and spiked Exxsol D60 was performed and compared against simplified numerical model results. This potential relates to the flow rate of tapped water from the bottom of the pipe to the water cut of the tapped stream. To mimic the separation characteristics of a real crude-water mixture, Exxsol D60 was spiked with small amounts of crude oil. A pipe separator with two parallel branches and one tapping point was used to measure drainage potential experimentally. There was a slight decrease in separation performance for the spiked Exxsol D60 in general when compared with the unspiked oil’s drainage potential curves. However, for low inlet water cuts, the performance of the former was significantly worse than the latter. There was, in general, a fair agreement between experimental and numerical drainage potential curves. The flow patterns of the oil–water mixture approaching the tapping point are the major determining factors of drainage potential curves. Results of this work could be employed to predict the performance and design of bulk oil–water pipe separators that have one or multiple tapping points.
A Two-Phase Hybrid Trading of Green Certificate under Renewables Portfolio Standards in Community of Active Energy Agents
Authors: Tan Yaxin , Xu Zhiyu , Xu Weisheng
Published: September 2022

The future distribution network is a community involving numerous active energy agents (AEAs) and a local operator. Each AEA is obligated to meet the renewables portfolio standards (RPS) with enough green certificates (GCs), which can be obtained from renewable energy consumption or from GC trading. This paper concentrates on the GC trading in AEA community and proposes a two-phase hybrid mechanism, which combines the peer-to-peer (P2P) phase and the centralized phase. In Phase 1, GCs are traded among AEAs in P2P manner. All AEAs are classified into two types: naïve and sophisticated, each of which has the specific preference in GC trading. Additionally, each AEA finds trading partners by adopting multi-option-based matching. In Phase 2, the remaining GCs are traded between AEAs and the local operator. Numeric studies are performed on a 30-AEA community in three different market scenarios: globally balanced, undersupplied, and oversupplied. Simulation results indicate the optimality of bi-option, verify the effectiveness of the hybrid trading, and reveal the economic advantages over the sole centralized counterpart. The impact of AEA type is also discussed on both updating quotation and concluding deals.
Fusion of Vermicompost and Sewage Sludge as Dark Fermentative Biocatalyst for Biohydrogen Production: A Kinetic Study
Authors: Karthikeyan Balakumar , Gokuladoss Velvizhi
Published: September 2022

The present study explores the synergy between vermicompost and the anaerobic sewage sludge as inoculum for biohydrogen production using food waste as a substrate. Experiments were designed and performed in two phases of operation. In the first phase, the vermicompost (VC) was used as inoculum and food waste as substrate at three different organic loading rates of 10 gVS/L (VC1), 20 gVS/L (VC2), and 30 gVS/L (VC3). In the second phase of operation, the inoculums were combined with a proportion of 50% (VC+AS). The study showed an effective biohydrogen production of 20 gVS/L when the mixing ratio of vermicompost and anaerobic sludge was 50:50. The results inferred that effective synergy was observed between the combined consortia of the inoculum, which induces a more effective metabolic pathway for enhanced hydrogen production. H2 production was 33 mL/gVS (VC1), 48 mL/gVS (VC2), 35 mL/gVS (VC3), 46 mL/gVS (AS), and 50 mL/gVS (VC+AS). Heat pretreatment (100–120 °C) of the inoculum suppresses the methane-producing microorganisms and increases the hydrogen-producing microbes. In addition to hydrogen production, different metabolites are formed in the liquid phase, such as acetic acid, butyric acid, and propionic acid of 2.957 g/L, 4.286 g/L, and 2.123 g/L, respectively, with an energy content of 257 J/day with VC+AS. In addition, a kinetic model was studied for the cumulative hydrogen production curves using the modified Gompertz model, and the fit infers that the experimental data fitted well, with high coefficients of determination for VC+AS (R2 (G) > 0.99).
Gas Sources, Migration, and Accumulation Systems: The Shallow Subsurface and Near-Seafloor Gas Hydrate Deposits
Authors: Liu Liping , Chu Fengyou , Wu Nengyou , Zhang Lei , Li Xiaohu , Li Huaiming , Li Zhenggang , Zhang Weiyan , Wang Xiao
Published: September 2022

Compared with the deeply buried marine gas hydrate deposits, gas hydrates in the shallow subsurface, close to and at the seafloor, have attracted more attention owing to their concentrated distribution, high saturation, and easy access. They accumulate at relatively shallow depths <100–120 m and occur as gas hydrate-bearing mounds (also known as hydrate outcrops, pingoes) at the seafloor derived from the growth of hydrates in the shallow subsurface or as pure hydrate chunks formed by gas leakage. This paper reviews and summarizes such gas hydrate systems globally from the perspective of gas sources, migration pathways, and accumulation processes. Here, we divided them into four categories: fault-chimney-controlled, diapir-fault-controlled, fault-controlled, and submarine mud volcano-controlled deposits. Gas chimneys originate immediately above the restricted regions, mostly affected by faults where high gas concentrations trigger elevated pore fluid pressures. Diapirism derives a dendritic network of growth faults facilitating focused gas discharge and hydrate formation near the seafloor. Furthermore, pre-existing faults or fractures created by overpressured gas from greater depths in accretionary tectonics at convergent margins act as preferential pathways channeling free gas upwards to the seafloor. Gas flux rates decrease from the submarine mud volcano center to its margins, creating a concentric pattern of distributing temperature, gas concentrations, and hydrate contents in shallow sediments around the mud volcano. Hydrate-bound hydrocarbons are commonly of thermogenic origin and correspond to high-background geothermal conditions, whereas microbial gas is dominant in a few cases. The presence of heavier hydrocarbons mitigates the inhibition of hydrate formation by salt or heat. Fluid migration and pathways could be compared to the “blood” and “bones” in an organic system, respectively. The root of a pathway serves as the “heart” that gathers and provides considerable free gas concentrations in a restricted area, thereby triggering pore fluid pressures as one important drive force for focused fluid flow in impermeable sediments (the organic system). Besides the suitable temperature and pressure conditions, a prerequisite for the formation and stability of hydrate deposits in the shallow subsurface and at the seafloor is the sufficient supply of gas-rich fluids through the hydrate stability zone. Thus, the proportion of gas migrating from deep sources is significantly larger than that trapped in hydrates. As such, such marine hydrate deposits seem more like temporary carbon storage rather than the main culprit for climate warming at least in a short period.
Modelling and Performance Analysis of an Autonomous Marine Vehicle Powered by a Fuel Cell Hybrid Powertrain
Authors: De Lorenzo Giuseppe , Piraino Francesco , Longo Francesco , Tinè Giovanni , Boscaino Valeria , Panzavecchia Nicola , Caccia Massimo , Fragiacomo Petronilla
Published: September 2022

This paper describes the implementation of a hydrogen-based system for an autonomous surface vehicle in an effort to reduce environmental impact and increase driving range. In a suitable computational environment, the dynamic electrical model of the entire hybrid powertrain, consisting of a proton exchange membrane fuel cell, a hydrogen metal hydride storage system, a lithium battery, two brushless DC motors, and two control subsystems, is implemented. The developed calculation tool is used to perform the dynamic analysis of the hybrid propulsion system during four different operating journeys, investigating the performance achieved to examine the obtained performance, determine the feasibility of the work runs and highlight the critical points. During the trips, the engine shows fluctuating performance trends while the energy consumption reaches 1087 Wh for the fuel cell (corresponding to 71 g of hydrogen) and 370 Wh for the battery, consuming almost all the energy stored on board.
Implications of Increasing Fuel Costs for Supply Chain Strategy
Authors: Milewska Beata , Milewski Dariusz
Published: September 2022

The supply chain strategy has a significant impact on energy consumption. This strategy determines the location of individual links in the chain (suppliers, producers, distributors), which affects the costs of logistics processes, including, in particular, transport processes. Currently, due to the rapid increase in fuel prices, the issue of energy consumption in the supply chains is becoming increasingly important. The aim of the article is to present the impact of the increase in fuel and energy costs on the costs of logistics processes and, as a result, on the profitability of different supply chain strategies. The profitability of changing from global to local sources of supply as a result of rising energy prices was especially taken into account. The article presents the results of interviews from enterprises carried out by the authors and the results of simulations carried out using a model developed by the authors. The need to conduct such research resulted from the existing research gap and the need to take into account contemporary changes and conditions. The research was conducted in a period of rapid increase in fuel and energy costs. Both the research conducted by the method of interviews, as well as the calculations and simulations indicated that despite a very large increase in rates for transport services, especially in maritime transport, it is still not profitable to relocate production from the Far East to Europe.
Agroforestry-Enhancing Typification of Agricultural Territories as a Basic Condition for Increasing the Efficiency of Protective Afforestation
Authors: Tubalov Alexey A.
Published: September 2022

Upgrading the scale of agricultural production and the effectiveness of protective afforestation is based on the strategy of identifying similar crop production conditions. The given research identifies the territories that require different approaches to forest reclamation. The research is based on the use of remote data as well as geoinformation research methods. The area for investigation is the territory of the right bank of the Khoper River in the Volgograd region. This territory is characterized by the distribution of the most fertile soils in the world, southern chernozems and typical chernozems. The study area is a long-standing historical center of agricultural production, and the task of protecting and increasing the fertility of cultivated soils is very urgent for this territory. The investigation of the catchment areas for identifying spatial patterns is an important methodological aspect of the present research. The studies were carried out within the network of catchments in ravines and gullies. The parameters of the areas of each catchment were used to calculate the specific indicators characterizing the territory. Mapping the territory of the research area made it possible to identify the range of parameters which characterize the erosion process as well as the parameters that cause its development. The studies of the interdependence of land structure and relief parameters made it possible to identify the processes for evaluating the agroecological state of the territories and their typification. These parameters include: erosive dissection, km/km2; the density of ravine tops, units/km2; the area of arable land in the catchment located on slopes with a steepness of more than 3°, %; and the nonforested area of slopes with a steepness of more than 8°. The values of indicators estimated on the basis of statistical scoring procedures became the basis for the allocation of four groups of conditional agroecological states of territories: normal, risk, crisis, and disaster. These groups differ in the set of reclamation measures used and their focus and scope.
Can Forest Restoration Enhance the Water Supply to Respond to Climate Change?—The Case of North Korea
Authors: Yeo Hyun-Chul , Lim Chul-Hee
Published: September 2022

North Korea is a representative country that should restore its forest ecosystem, which is vital for responding to climate change. In this study, we assessed the extent to which afforestation can reduce the climate change impact on water resources by adding an afforestation scenario to the variables used to estimate the forest water yield. We applied the InVEST seasonal water yield model and constructed a data ensemble of the SSP5–8.5 scenario for this simulation. In the projection of future forest water supply according to the SSP5–8.5 scenario, baseflow and local recharge decreased by approximately 25%, and quickflow increased by approximately 47%, compared to the baseline period. Under the three reforestation scenarios, the future water supply from the forests showed significant positive changes. The baseflow increased by approximately 4%, 15%, and 28% in the reforestation scenario of Level 1, Level 2, and Level 3, respectively. In a Level 3 scenario, most of the baseflow and local recharge, which had decreased owing to the impact of climate change, was recovered. The baseflow in Level 3 was 26,882 million m3 y−1, which was approximately 98% of that in the baseline period. The Taedong River and Chongchon River, which are the major granary areas in North Korea, were directly affected by the climate change. However, it was confirmed that the water supply in these areas can be increased through forest restoration. These results indicate the deterministic role of forest restoration in increasing the water supply.
Transcriptome Analysis of Immune Response against Streptococcus agalactiae Infection in the Nile Tilapia GIFT Strain
Authors: Zhou Tao , Fang Zhihua , Duarte Daniel F. C. , Fernandes Stefan A. , Lu Ying , Guo Jing , Gui Lang , Chen Liangbiao
Published: September 2022

Streptococcus agalactiae (group B streptococcus, GBS), a broad-spectrum pathogen, causes great economic losses in fish aquaculture, especially the industry of tilapia. Until now, the knowledge of the immune response mechanism against S. agalactiae infection in tilapia has been limited. In the present study, the gill transcriptome of the tilapia from the GBS and the phosphate buffered saline (PBS) groups were sequenced. The transcriptomic analysis results presented the differentially expressed genes (DEGs) at different time points (DEGs number, 6 h: 2122, 9 h: 1851, 15 h: 1791, and 18 h: 2395) after GBS injection, and significantly enriched immune-related gene ontology (GO) terms such as the innate immune response. The significantly enriched immune pathways included the Toll-like receptor signaling pathway, the nucleotide oligomerization domain (NOD)-like receptor signaling pathway, the cytosolic-DNA sensing pathway, and the intestinal immune network for Immunoglobulin A (IgA) production. Most of the DEGs in Toll-like receptor signaling, NOD-like receptor signaling, and cytosolic-DNA sensing pathways presented upregulations at 18 h, which indicated that the innate immune pathways were activated. Two immune-related pathways (phagosome and cell adhesion molecules) were significantly enriched at all time points, suggesting that these two pathways might also play important roles in the immune response against the GBS infection. The results of HE staining showed that the gills of tilapia were damaged seriously at 9 h post-infection, which might be due to the possibility of pyroptosis resulting from the changes of DEGs in the NOD-like receptor signaling pathway. This study provided new insight into the mechanisms of gill damage in fish infected with S. agalactiae.
Antibiofilm, AntiAdhesive and Anti-Invasive Activities of Bacterial Lysates Extracted from Pediococcus acidilactici against Listeria monocytogenes
Authors: Lee Han Bin , Kim Ki Hwan , Kang Gweon Ah , Lee Kwang-Geun , Kang Seok-Seong
Published: September 2022

This study aimed to investigate whether bacterial lysates (BLs) extracted from Pediococcus acidilactici reduce Listeria monocytogenes biofilm formation, as well as adhesion to and invasion of human intestinal epithelial cells. Pretreatment with P. acidilactici BLs (20, 40, and 80 μg/mL) significantly inhibited L. monocytogenes biofilm formation on the surface of polystyrene (p < 0.05). Fluorescence and scanning-electron-microscopic analyses indicated that L. monocytogenes biofilm comprised a much less dense layer of more-dispersed cells in the presence of P. acidilactici BLs. Moreover, biofilm-associated genes, such as flaA, fliG, flgE, motB, degU, agrA, and prfA, were significantly downregulated in the presence of P. acidilactici BLs (p < 0.05), suggesting that P. acidilactici BLs prevent L. monocytogenes biofilm development by suppressing biofilm-associated genes. Although P. acidilactici BLs did not dose-dependently inhibit L. monocytogenes adhesion to and invasion of intestinal epithelial cells, the BLs effectively inhibited adhesion and invasion at 40 and 80 μg/mL (p < 0.05). Supporting these findings, P. acidilactici BLs significantly downregulated L. monocytogenes transcription of genes related to adhesion and invasion, specifically fbpA, ctaP, actA, lapB, ami, and inlA. Collectively, these results suggest that P. acidilactici BLs have the potential to reduce health risks from L. monocytogenes.
The Quality Characteristics Formation and Control of Salted Eggs: A Review
Authors: Li Xiaoya , Chen Shuping , Yao Yao , Wu Na , Xu Mingsheng , Zhao Yan , Tu Yonggang
Published: September 2022

Salted egg, a traditional characteristic processed egg product in China, is popular among consumers at home and abroad. Salted egg quality characteristics formation primarily includes the hydration of egg white, the solidification of egg yolk, the unique color and flavor of salted egg yolk, and the formation of white, fine, and tender egg whites and loose, sandy, and oily egg yolks after pickling and heating. The unique quality characteristics of salted eggs are mostly caused by the infiltration dehydration of salt, the intermolecular interaction of proteins, and the oxidation of lipids. In recent years, to solve the problems of salted eggs having high salinity, long production cycle, and short storage period, the pickling technology for salted egg has been improved and researched, which has played a significant role in promoting the scientific production of salted eggs. This paper summarizes the mechanisms of salted egg quality characteristics formation and factors influencing quality, with a perspective of providing a theoretical basis for the production of high-quality salted eggs.
Semi-Local Convergence of a Seventh Order Method with One Parameter for Solving Non-Linear Equations
Authors: Argyros Christopher I. , Argyros Ioannis K. , Regmi Samundra , John Jinny Ann , Jayaraman Jayakumar
Published: September 2022

The semi-local convergence is presented for a one parameter seventh order method to obtain solutions of Banach space valued nonlinear models. Existing works utilized hypotheses up to the eighth derivative to prove the local convergence. But these high order derivatives are not on the method and they may not exist. Hence, the earlier results can only apply to solve equations containing operators that are at least eight times differentiable although this method may converge. That is why, we only apply the first derivative in our convergence result. Therefore, the results on calculable error estimates, convergence radius and uniqueness region for the solution are derived in contrast to the earlier proposals dealing with the less challenging local convergence case. Hence, we enlarge the applicability of these methods. The methodology used does not depend on the method and it is very general. Therefore, it can be used to extend other methods in an analogous way. Finally, some numerical tests are performed at the end of the text, where the convergence conditions are fulfilled.
Characterization of CRH-Binding Protein (CRHBP) in Chickens: Molecular Cloning, Tissue Distribution and Investigation of Its Role as a Negative Feedback Regulator within the Hypothalamus–Pituitary–Adrenal Axis
Authors: Wan Yiping , Zhang Zheng , Lin Dongliang , Wang Xinglong , Huang Tianjiao , Su Jiancheng , Zhang Jiannan , Li Juan , Wang Yajun
Published: September 2022

Corticotropin (ACTH) is a pituitary hormone playing important roles in stress response within the hypothalamus–pituitary–adrenal (HPA) axis. The biosynthesis and secretion of ACTH are controlled by multiple factors, including corticotropin-releasing hormone (CRH). As a key hypothalamus-derived regulator, CRH binds to corticotropin-releasing hormone receptor 1 (CRHR1) in the anterior pituitary gland to regulate ACTH synthesis and release. Thus, CRH-binding protein (CRHBP), which binds CRH with high affinity to inhibit CRH-induced ACTH secretion from pituitary cells, draws wide attention. In contrast to the extensive investigation of CRHBP in mammals and other lower vertebrates, the gene structure, tissue expression and physiological functions of CRHBP in birds remain largely unknown. In the present study, using chicken (c-) as our animal model, we examined the gene structure, tissue expression and functionality of CRHBP. Our results showed that: (1) cCRHBP cDNA encodes a 345 amino acid precursor, which shares high sequence identity with that of mammals, reptiles, frogs and fish; (2) cCRHBP is abundantly expressed in the brain (cerebrum and hypothalamus), pituitary and ovary; (3) cCRHBP inhibits the signaling of cCRHRs induced by cCRH, thus reducing the cCRH-induced ACTH secretion from cultured chick pituitary cells; (4) stress mediators (e.g., glucocorticoids) and stress significantly upregulate CRHBP mRNA expression in chickens, supporting its role as a negative feedback regulator in the HPA axis. The present study enriches our understanding of the conserved roles of CRHBP across vertebrates. In addition, chicken is an important poultry animal with multiple economic traits which are tightly controlled by the HPA axis. The characterization of the chicken CRHBP gene helps to reveal the molecular basis of the chicken HPA axis and is thus beneficial to the poultry industry.
CRISPR/Cas9-Mediated Gene Editing of BnFAD2 and BnFAE1 Modifies Fatty Acid Profiles in Brassica napus
Authors: Shi Jianghua , Ni Xiyuan , Huang Jixiang , Fu Ying , Wang Tanliu , Yu Huasheng , Zhang Yaofeng
Published: September 2022

Fatty acid (FA) composition determines the quality of oil from oilseed crops, and thus is a major target for genetic improvement. FAD2 (Fatty acid dehydrogenase 2) and FAE1 (fatty acid elongase 1) are critical FA synthetic genes, and have been the focus of genetic manipulation to alter fatty acid composition in oilseed plants. In this study, to improve the nutritional quality of rapeseed cultivar CY2 (about 50% oil content; of which 40% erucic acid), we generated novel knockout plants by CRISPR/Cas9 mediated genome editing of BnFAD2 and BnFAE1 genes. Two guide RNAs were designed to target one copy of the BnFAD2 gene and two copies of the BnFAE1 gene, respectively. A number of lines with mutations at three target sites of BnFAD2 and BnFAE1 genes were identified by sequence analysis. Three of these lines showed mutations in all three target sites of the BnFAD2 and BnFAE1 genes. Fatty acid composition analysis of seeds revealed that mutations at all three sites resulted in significantly increased oleic acid (70–80%) content compared with that of CY2 (20%), greatly reduced erucic acid levels and slightly decreased polyunsaturated fatty acids content. Our results confirmed that the CRISPR/Cas9 system is an effective tool for improving this important trait.
Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract
Authors: Al-Hamed Mohamed H. , Sayer John A. , Alsahan Nada , Edwards Noel , Ali Wafaa , Tulbah Maha , Imtiaz Faiqa
Published: September 2022

The use of next-generation sequencing (NGS) has helped in identifying many genes that cause congenital anomalies of the kidney and urinary tract (CAKUT). Bilateral renal agenesis (BRA) is the most severe presentation of CAKUT, and its association with autosomal recessively inherited genes is expanding. Highly consanguineous populations can impact the detection of recessively inherited genes. Here, we report two families harboring homozygous missense variants in recently described genes, NPNT and GFRA1. Two consanguineous families with neonatal death due to CAKUT were investigated. Fetal ultrasound of probands identified BRA in the first family and severe renal cystic dysplasia in the second family. Exome sequencing coupled with homozygosity mapping was performed, and Sanger sequencing was used to confirm segregation of alleles in both families. In the first family with BRA, we identified a homozygous missense variant in GFRA1: c.362A>G; p.(Tyr121Cys), which is predicted to damage the protein structure. In the second family with renal cystic dysplasia, we identified a homozygous missense variant in NPNT: c.56C>G; p.(Ala19Gly), which is predicted to disrupt the signal peptide site. We report two Saudi Arabian consanguineous families with CAKUT phenotypes that included renal agenesis caused by missense variants in GFRA1 and NPNT, confirming the role of these two genes in human kidney development.
An Interactive WebGIS Integrating Environmental Susceptibility Mapping in a Self-Burning Waste Pile Using a Multi-Criteria Decision Analysis Approach
Authors: Duarte Lia , Teodoro Ana Cláudia , Santos Patrícia , Rodrigues de Almeida Cátia , Cardoso-Fernandes Joana , Flores Deolinda
Published: September 2022

Mining activities promote resulting wastes, so coal mines are prone to release contaminants to the environment, namely to the soil and water. Therefore, the analysis of this type of risk is crucial in waste pile management. The São Pedro da Cova (Porto, Portugal) coal waste pile has been studied in recent years, with several data acquired from 2019–2021 under a research project using distinct methodologies. These results are now combined in a multi-approach method to estimate the environmental impacts of the waste pile and identify the contamination. With the integration of all the data in a Geographical Information System (GIS) environment, and to fulfill a scientific gap, this study aims: (i) to create a susceptibility map of contamination in the areas surrounding the self-burning coal waste pile in São Pedro da Cova, using Analytical Hierarchy Process (AHP) and Fuzzy AHP approaches; and (ii) to develop a webGIS application incorporating all the information acquired that can be useful for the residents of São Pedro da Cova and also to the decision-making public entities and researchers. The results obtained show that the contamination susceptibility is higher surrounding the abandoned mine, particularly along the waste piles and the corresponding runoff areas, which can be especially sensitive.
Customized Deep Learning Classifier for Detection of Acute Lymphoblastic Leukemia Using Blood Smear Images
Authors: Sampathila Niranjana , Chadaga Krishnaraj , Goswami Neelankit , Chadaga Rajagopala P. , Pandya Mayur , Prabhu Srikanth , Bairy Muralidhar G. , Katta Swathi S. , Bhat Devadas , Upadya Sudhakara P.
Published: September 2022

Acute lymphoblastic leukemia (ALL) is a rare type of blood cancer caused due to the overproduction of lymphocytes by the bone marrow in the human body. It is one of the common types of cancer in children, which has a fair chance of being cured. However, this may even occur in adults, and the chances of a cure are slim if diagnosed at a later stage. To aid in the early detection of this deadly disease, an intelligent method to screen the white blood cells is proposed in this study. The proposed intelligent deep learning algorithm uses the microscopic images of blood smears as the input data. This algorithm is implemented with a convolutional neural network (CNN) to predict the leukemic cells from the healthy blood cells. The custom ALLNET model was trained and tested using the microscopic images available as open-source data. The model training was carried out on Google Collaboratory using the Nvidia Tesla P-100 GPU method. Maximum accuracy of 95.54%, specificity of 95.81%, sensitivity of 95.91%, F1-score of 95.43%, and precision of 96% were obtained by this accurate classifier. The proposed technique may be used during the pre-screening to detect the leukemia cells during complete blood count (CBC) and peripheral blood tests.
The Effect of Auriculotherapy on Situational Anxiety Trigged by Examinations: A Randomized Pilot Trial
Authors: Vieira Andreia , Sousa Paula , Moura Alexandra , Lopes Lara , Silva Cristiane , Robinson Nicola , Machado Jorge , Moreira António
Published: September 2022

Background: Auriculotherapy may activate the parasympathetic nerve system and reduce anxiety levels. Short-term auriculotherapy’s effects and safety on university students’ anxiety levels was assessed prior to exams. Methods: A randomized, controlled pilot trial was conducted. The day before the exam, university students were randomly allocated to the auriculotherapy group (AA, n = 13) or the waiting-list group (WG, n = 13). Baseline measures were taken 4 weeks before the exam at Time point (TP 0); at 7.30 a.m. on the day before the exam (TP I); at 11 a.m. before auriculotherapy (TP II); 30 min after AA (TP III); and at 7.30 a.m. before the exam (TP IV). The outcomes were the State-Trait-Anxiety Inventory (STAI); quality of night-sleep, Visual Analogue scale (VAS) for anxiety, and salivary cortisol. Adverse events were also recorded. Results: A total of 26 students participated in this study and became more anxious as assessed by STAI in TPII (p = 0.002) and TPIV (p = 0.000) than TP0. AA reduced the STAI in TPIII (p = 0.045) and PIV (p = 0.001) and the VAS (p = 0.012) in TPIV. Cortisol was reduced in TPIII (p = 0.004), and the AA slept better (p = 0.014) at TPIV. Discomfort at the auricular site was reported in only one AA participant. Conclusions: Auriculotherapy appeared safe and effective in reducing anxiety levels before university exams.
Practices and Strategies of Health Professionals during the COVID-19 Pandemic—Between Limitations and Opportunities
Authors: Glasdam Stinne , Jacobsen Frode F. , Stjernswärd Sigrid
Published: September 2022

The COVID-19 pandemic was declared as such in March 2020 [...]
Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species
Authors: Noites Alexandra , Araújo Bruno , Machado Jorge , Pinto Eugénia
Published: September 2022

(1) Background: Candidiasis is a fungal infectious disease caused by opportunistic Candida species. The incidence of candidiasis has improved, due to prolonged antibiotic therapy and an increased number of immunocompromised patients. The purpose of this study was to evaluate if decoctions and essential oil (EO) of neem (Azadirachta indica, Meliaceae family), coptidis (Coptis chinensis, Ranunculaceae family), magnolia (Magnolia officinalis, Magnoliaceae family), scutellaria (Scutellaria barbata, Lamiaceae family), and the EO of manuka (Leptospermum scoparium, Myrtaceae family), have antifungal activity in vitro against some clinically prevalent species of Candida. (2) Methods: The antifungal activity was studied by the determination of the minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) against five Candida strains. The effect in dimorphic transition of Candida albicans was also evaluated for the two plants with higher antimicrobial behavior. (3) Results: C. chinensis decoction and EO and L. scoparium EO exhibited antifungal activity in Candida spp. In addition to the fact that both C. chinensis decoction and EO proved strong antifungal activity, L. scoparium EO also displayed a relevant inhibitory effect on the dimorphic transition. (4) Conclusions: The results provided support for the potential use of C. chinensis and L. scoparium in the treatment of infections by Candida spp.
Multidimensional Assessment of Individuals with Parkinson’s Disease: Development and Structure Validation of a Self-Assessment Questionnaire
Authors: Mendes Luanne Cardoso , Marques Isabela Alves , Alves Camille Marques , Vieira Marcus Fraga , Júnior Edgard Afonso Lamounier , Pereira Adriano Alves , Naves Eduardo Lázaro Martins , Oliveira Fábio Henrique Monteiro , Bourhis Guy , Pino Pierre , Morère Yann , Andrade Adriano de Oliveira
Published: September 2022

(1) Background: Several instruments are used to assess individuals with Parkinson’s disease (PD). However, most instruments necessitate the physical presence of a clinician for evaluation, were not designed for PD, nor validated for remote application. (2) Objectives: To develop and validate a self-assessment questionnaire that can be used remotely, and to assess the respondents’ health condition. (3) Methods: A questionnaire, so-called Multidimensional Assessment Questionnaire for Individuals with PD (MAQPD), was developed, administered remotely, and completed by 302 people with PD. MAQPD was validated using factor analysis (FA). The participants’ level of impairment was estimated using factor loadings. The scale’s accuracy was assessed estimating floor and ceiling effects and Cronbach’s alpha. (4) Results: FA suggested classifying the questions into daily activities, cognition, and pain. The respondents did not have extremely severe impairment (most scores ranged from 100 to 180 points), and the factors with the lowest scores were cognition and pain. The instrument had no significant floor or ceiling effects (rates less than 15%), and the Cronbach’s alpha value was larger than 0.90. (5) Conclusion: MAQPD is the only remote self-administered tool found in the literature capable of providing a detailed assessment of the general health status of individuals with PD.
A Study on the COVID-19 Preventive Behaviors of Automobile Manufacturing Workers in South Korea
Authors: Kim Ji-Hye , Song Hye-Young , Park Jin-Hee , Kang Purum , Lee Hyun-Ju
Published: September 2022

The present study used a cross-sectional, descriptive survey design to investigate the influencing factors of COVID-19-related infection prevention behaviors of workers in the automobile manufacturing sector. An online survey was conducted on 157 workers in the automobile manufacturing sector of a company in Korea. We analyzed the collected data using SPSS to test whether there were significant differences in COVID-19 risk perception, crisis communication, health literacy, and infection prevention behaviors according to the general characteristics of the participants. An independent sample t-test and a one-way analysis of variance (ANOVA) were performed. A Pearson’s correlation analysis was performed to identify the correlations among COVID-19 risk perception, crisis communication, health literacy, and infection prevention behaviors. Multiple regression analysis was performed to identify the influencing factors of COVID-19 infection prevention behaviors. The regression model was found to be significant, and the employment period at current job, COVID-19 prevention education, source of information, COVID-19 risk perception, crisis communication, and health literacy were also found to be significant. Among the demographic variables, employment period at current job of 5–10 years showed a higher level of infection prevention behaviors than that of <5 years. Moreover, the level of infection prevention behaviors was also significantly higher when COVID-19-related information was acquired through the KDCA/health center. Higher COVID-19 risk perception, crisis communication, and health literacy were associated with significantly higher levels of infection prevention behaviors. Therefore, based on the results, health managers need to develop programs and educate and improve information comprehension and crisis communication skills in order to promote workers’ infection prevention behaviors of emerging infectious diseases in an era of global change.
Evapotranspiration Based Irrigation Trials Examine Water Requirement, Nitrogen Use, and Yield of Romaine Lettuce in the Salinas Valley
Authors: Cahn Michael D. , Johnson Lee F. , Benzen Sharon D.
Published: September 2022

Cool season vegetables require adequate soil moisture to assure that maximum yield and quality are achieved. On California’s central coast, where the majority of cool season vegetables are produced in the US, long-term overpumping of irrigation water has reduced groundwater levels and led to environmental degradation. Two evapotranspiration (ET) based irrigation field trials were performed near Salinas CA (USA) to determine if ET-based irrigation scheduling could conserve water while producing romaine lettuce (cv. Sun Valley) of commercially viable yield. Sprinklers were used for seed germination and crop establishment. Four drip irrigation treatments were then imposed using a randomized complete block design with six replications. The CropManage decision-support model was used to estimate the full (100%) crop water requirement based mainly on ET replacement. Other treatments included 50% 75% and 150% of the full water requirement. The 100% treatment received 185 mm of water in 2015 and 247 mm in 2016, both of which were well below prior guidance and grower reports. Yields from the 100% and 150% treatments were not significantly different and were similar to industry average, while yields were significantly lower for the 50% and 75% treatments. The 100% treatment had the highest water use efficiency, and the 100% and 150% treatments together had the highest nitrogen recovery efficiency. Irrigation of romaine near the 100% ET replacement level can potentially reduce environmental impacts associated with nitrate leaching and surface runoff.
Towards Meaning in Life: A Path Analysis Exploring the Mediation of Career Adaptability in the Associations of Self-Esteem with Presence of Meaning and Search for Meaning
Authors: Gori Alessio , Topino Eleonora , Svicher Andrea , Di Fabio Annamaria
Published: September 2022

In the contemporary world of work, workers are engaged more frequently in career choices to cope with changing work and working conditions. In this scenario, the well-being of workers is under threat. This study aims to examine the effect of career adaptability as a preventive resource on the relationship between self-esteem and meaning in life. Three-hundred Italian workers (67.3% females, mean age = 41.90; SD = 12.54) completed an online survey enclosing the Career Adapt-Abilities Scale, the Rosenberg self-esteem scale, and the Meaning in Life Questionnaire. Data were analyzed through a path analysis by implementing a mediation model to test the hypothesized relationship. The results show that career adaptability partially mediated the relationship between self-esteem and meaning in life, both considering the presence of meaning and the search for meaning dimensions. The findings expand current knowledge on the relationship between self-esteem, career adaptability and meaning in life in workers with implications for research and intervention.
Investigating the Variation of Benzene and 1,3-Butadiene in the UK during 2000–2020
Authors: Holland Rayne , Khan M. Anwar H. , Matthews James C. , Bonifacio Sophia , Walters Rhian , Koria Priya , Clowes Joanna , Rodgers Karla , Jones Temi , Patel Leeya , Cross Rhianna , Sandberg Freya , Shallcross Dudley E.
Published: September 2022

The concentrations of benzene and 1,3-butadiene in urban, suburban, and rural sites of the U.K. were investigated across 20 years (2000–2020) to assess the impacts of pollution control strategies. Given the known toxicity of these pollutants, it is necessary to investigate national long-term trends across a range of site types. We conclude that whilst legislative intervention has been successful in reducing benzene and 1,3-butadiene pollution from vehicular sources, previously overlooked sources must now be considered as they begin to dominate in contribution to ambient pollution. Benzene concentrations in urban areas were found to be ~5-fold greater than those in rural areas, whilst 1,3-butadiene concentrations were up to ~10-fold greater. The seasonal variation of pollutant concentration exhibited a maximum in the winter and a minimum in the summer with summer: winter ratios of 1:2.5 and 1:1.6 for benzene and 1,3-butadiene, respectively. Across the period investigated (2000–2020), the concentrations of benzene decreased by 85% and 1,3-butadiene concentrations by 91%. A notable difference could be seen between the two decades studied (2000–2010, 2010–2020) with a significantly greater drop evident in the first decade than in the second, proving, whilst previously successful, legislative interventions are no longer sufficiently limiting ambient concentrations of these pollutants. The health impacts of these pollutants are discussed, and cancer impact indices were utilized allowing estimation of cancer impacts across the past 20 years for different site types. Those particularly vulnerable to the adverse health effects of benzene and 1,3-butadiene pollution are discussed.
Measurement of Intermediate Frequency Magnetic Fields Generated by Household Induction Cookers for Epidemiological Studies and Development of an Exposure Estimation Model
Authors: Kitajima Takumi , Schüz Joachim , Morita Akemi , Ikeda Wakaha , Tanaka Hirokazu , Togawa Kayo , Gabazza Esteban C. , Taki Masao , Toriyabe Kuniaki , Ikeda Tomoaki , Sokejima Shigeru
Published: September 2022

Introduction: Exposure assessment of intermediate frequency (IF) electromagnetic fields (EMFs) is difficult and epidemiological studies are limited. In the present study, we aimed to estimate the exposure of pregnant women to IF-EMFs generated by induction cookers in the household using a questionnaire and discussed its applicability to epidemiological studies. Method: Two main home-visit surveys were conducted: a Phase 1 survey to develop an estimation model and a Phase 2 survey to validate the model. The estimation model included the following variables: wattage, cookware diameter, and distance from the hob center (center of the stove). Four models were constructed to determine the importance of each variable and the general applicability for epidemiological studies. In addition, estimated exposure values were calculated based on the Phase 2 survey questionnaire responses and compared with the actual measured values using the Spearman rank correlation coefficient. Result: The average value of the magnetic field measured in the Phase 1 survey was 0.23 μT (variance: 0.13) at a horizontal distance of 30 cm at the height of the cooking table. The highest validity model was inputted distance from the hob center to the body surface that is variable (correlation coefficient = 0.54, 95% confidence interval: 0.22–0.75). No clear differences were identified in the correlation coefficients for each model (z-value: 0.09–0.18, p-value: 0.86–0.93). Discussion and Conclusions: No differences were found in the validity of the four models. This could be due to the biased wattage of the validation population, and for versatility it would be preferable to use three variables (distance, wattage, and estimation using the diameter of the cookware) whenever possible. To our knowledge, this is the first systematic measurement of magnetic fields generated by more than 70 induction cookers in a real household environment. This study will contribute to finding dose–response relationships in epidemiological studies of intermediate-frequency exposure without the use of instrumentation. One of the limitations of this study is it estimates instantaneous exposure in place during cooking only.
Access and Participation of Students with Disabilities: The Challenge for Higher Education
Authors: Fernández-Batanero José María , Montenegro-Rueda Marta , Fernández-Cerero José
Published: September 2022

Access to university is a right for all people; however, access to higher education for people with disabilities is still a challenge. The present study, based on a systematic review of the literature, aims to report on the challenges faced by students with disabilities in accessing and participating in higher education. The systematic review of four databases resulted in 20 studies published between 2011 and 2021. The results indicate that students with disabilities face numerous challenges in accessing university education. Based on the results, strategies are proposed in order to provide equal opportunities and success in higher education for students with disabilities.