bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN KAWASAN KONSERVASI TANAMAN OBAT BERBASIS KEARIFAN LOKAL MASYARAKAT ADAT MAPUR
Authors: Prayoga Gigih Ibnu , Faradis Syuraya , Sari Prada , Anggia Suci Dwi , Saputra Adi Indra , Saputri Nova , Delianti Noveni , Patilawati Pariza , Ramadhon Ramadhon , Naswanto Sekar Kinanti Ramadhini , Gunzhales William Fauzhi , Yuristian Yuristian
Published: April 2023

Dusun Air Abik memiliki Sumber Daya Alam yang melimpah khususnya tanaman obat. Populasi tanaman obat akan semakin berkurang jika tidak adanya upaya untuk tetap mempertahankan tanaman obat tersebut. Belum tersedianya wadah pembelajaran mengenai upaya pelestarian atau konservasi tanaman obat merupakan salah satu faktor yang menjadi penghambat dalam meningkatkan kesadaran masyarakat akan pentingnya konservasi tanaman obat untuk dilakukan. Pengabdian ini bertujuan melestarikan tanaman obat khas adat Mapur melalui kegiatan konservasi yang berkelanjutan serta mengembangkan produk tanaman obat yang menghasilkan sehingga dapat membantu mewujudkan Dusun Air Abik yang lebih maju. Hasil pengabdian menunjukkan bahwa latar belakang kemunculan program konservasi tanaman obat adalah dengan melihat potensi tanaman obat yang harus terus dijaga agar tidak hilang dan dapat dimanfaatkan sebagai usaha untuk meningkatkan perekonomian masyarakat. Hasil program meliputi terbentuknya kawasan konservasi secara in-situ dan ex-situ, peta persebaran tanaman obat, pengemasan produk yang lebih inovatif, dan terbentuknya kafe jamu merupakan tahapan dasar untuk program pengabdian sehingga masih diperlukan keberlanjutan program untuk mengembangkan kawasan konservasi dan mematenkan hasil produk tanaman obat di Dusun Air Abik.
USAHA BUDIDAYA IKAN LELE DAN IKAN NILA BERBASIS TEKNOLOGI PROBIO_FM DI CV DAM DESA PETALING BANGKA
Authors: Safira Riza , Kurniawan Kurniawan , Marlinda Feni , Wiralaga Lanang Satria , Adibrata Sudirman , Mardyani Yeyen
Published: April 2023

Mahasiswa Universitas Bangka Belitung melakukan kegiatan Merdeka Belajar Kampus Merdeka (MBKM) dalam Program Kedaireka Matching Fund Tahun 2022 dengan judul kegiatan yaitu Usaha Budidaya Ikan Lele dan Ikan Nila Berbasis Teknologi Probio_FM di CV DAM Desa Petaling Kabupaten Bangka. Tujuan kegiatan kewirausahan ini untuk mempercepat hasil produksi budidaya ikan lele dan ikan nila dengan menggunakan Probio_FM, mempopulerkan pemberian pakan dengan penambahan Probio_FM serta membentuk kelompok usaha perikanan budidaya berbasis teknologi Probio_FM. Probio_FM merupakan probiotik cair yang mengandung bakteri asam laktat yang berfungsi untuk memperbaiki kualitas air, mengurangi bau ammonia dan populasi lalat, mengurangi bau amis pada daging ikan, dapat menurunkan angka kematian pada ikan serta meningkatkan efisiensi penggunaan pakan. Metode yang digunakan dalam kegiatan ini meliputi survey lokasi kegiatan, persiapan lahan untuk KJA/KJT, penebaran benih ikan lele dan nila, pemberian pakan ikan dengan penambahan probio_FM, penyortiran, pemanenan, pemasaran serta membentuk kelompok usaha. Hasil dalam kegiatan ini telah dilakukan panen ikan nila dan ikan lele dengan lama waktu budidaya yaitu 2 bulan 2 minggu untuk ikan lele dengan bobot rata-rata 140gram. Total panen ikan lele sebanyak 330 kg dan ikan nila sebanyak 270 kg. Telah dibentuk kelompok usaha dengan nama Gerai FF Kedaireka. Probio_FM sangat berpengaruh terhadap pembesaran ikan lele dan ikan nila. Diharapkan semakin banyaknya pembudidaya yang menggunakan teknologi Probio_FM.
The Literasi Membaca di SMP MUHAMMADIYAH 23 Lubuk Palas Melalui Program Kampus Mengajar 3
Authors: Munthe Sinthya Maranatha hr , Tampubolon Sahlan , Silalahi Jojor , Munthe Herlin , Irawan Dedy
Published: April 2023

Kampus Mengajar 2021 merupakan program lanjutan dari Program Kampus Mengajar Perintis yang telah dilaksanakan pada tahun 2020 sebagai bukti dedikasi kampus melalui mahasiswa untuk bergerak menyukseskan pendidikan nasional dalam kondisi pandemi. Kampus Mengajar adalah bagian dari program Kampus Merdeka yang melibatkan mahasiswa di setiap kampus dari berbagai latar belakang pendidikan untuk membantu proses belajar mengajar di sekolah, khususnya pada jenjang SD dan memberikan kesempatan kepada mereka belajar dan mengembangkan diri melalui aktivitas di luar kelas perkuliahan. Indonesia sedang membutuhkan bantuan berbagai pihak untuk bergerak secara sinergis menyukseskan pendidikan nasional. Kampus Mengajar bertujuan untuk memberikan kesempatan kepada mahasiswa untuk belajar dan mengembangkan diri melalui aktivitas di luar kelas perkuliahan, membantu sekolah untuk memberikan pelayanan pendidikan yang optimal terhadap semua peserta didik pada jenjang SD dalam kondisi terbatas dan kritis selama pandemi dan memberikan kesempatan belajar optimal kepada semua peserta didik pada jenjang SD dalam kondisi terbatas dan kritis selama pandemi. Hasil dari program ini memberikan respon positif dari pihak di SMPS Muhammadiyah 23 Lubuk Palas dan berdampak baik dalam hal pembelajaran,adaptasi teknologidan administrasi sekolah,Kata kunci: Mahasiswa, kampus mengajar, di SMPS Muhammadiyah 23 Lubuk Palas
Survival outcomes used to generate version 9 American Joint Committee on Cancer staging system for anal cancer
Authors: Janczewski Lauren M. , Faski Joseph , Nelson Heidi , Gollub Marc J. , Eng Cathy , Brierley James D. , Palefsky Joel M. , Goldberg Richard M. , Washington M. Kay , Asare Elliot A. , Goodman Karyn A. ,   the American Joint Committee on Cancer Expert Panel on Cancers of the Lower Gastrointestinal, Anus Disease Site
Published: April 2023

The American Joint Committee on Cancer (AJCC) staging system for all cancer sites, including anal cancer, is the standard for cancer staging in the United States. The AJCC staging criteria are dynamic, and periodic updates are conducted to optimize AJCC staging definitions through a panel of experts charged with evaluating new evidence to implement changes. With greater availability of large data sets, the AJCC has since restructured and updated its processes, incorporating prospectively collected data to validate stage group revisions in the version 9 AJCC staging system, including anal cancer. Survival analysis using AJCC eighth edition staging guidelines revealed a lack of hierarchical order in which stage IIIA anal cancer was associated with a better prognosis than stage IIB disease, suggesting that, for anal cancer, tumor (T) category has a greater effect on survival than lymph node (N) category. Accordingly, version 9 stage groups have been appropriately adjusted to reflect contemporary long‐term outcomes. This article highlights the changes to the now published AJCC staging system for anal cancer, which: (1) redefined stage IIB as T1–T2N1M0 disease, (2) redefined stage IIIA as T3N0–N1M0 disease, and (3) eliminated stage 0 disease from its guidelines altogether.
Selection of the means of auxiliary transportation facilities and adaptation of their parameters to specific operation conditions
Authors: Herasymenko A. O , Rastsvietaiev V. O , Shyrin A. L
Published: April 2023

Purpose. To improve selection methods of operation schedules as well as means of auxiliary transportation facilities involving adaptation of their parameters to the specific application environment while preparing new extraction pillars for coal mining. Methodology. The current methods for substantiating the operational parameters of the means of internal mine transport do not take into account the impact of mining-geological and technological factors, which change inadequately in space and time, on their productivity. The recommended method for selecting transport and technological schemes and increasing their adaptability in the real conditions of the mine environment is based on the comprehensive use of methods of expert evaluation of the operational indicators of the new generation of auxiliary transport means and modeling of the conditions of their interaction with arch support and side rocks at the stages of mining and their operation when preparing new mining pillars for cleaning mining. Findings. The expert evaluation concerning technological features of mining field preparation as well as assembling and dismantling operations has determined that for the specific conditions of Western Donbas mines, the suspended diesel monorail locomotive and self-propelled machines are the most promising options. Gear clutch rail diesel locomotives are recommended as the auxiliary transport for the accelerated preparation of extraction pillar and introduction of a longwall into operation. Originality. New approaches have been substantiated to improve selection of the efficient means of auxiliary transportation facilities and identify their operational parameters for the well-timed preparation of extraction pillars for their removal under the intensified underground mining conditions. A transportation schedule has been proposed to supply heavy tonnage loads by means of the suspended diesel rail locomotives as well as methods to calculate the expected loads on suspension members of the monorail road taking into consideration physico-mechanical characteristics of roof rocks within a development mine working. Practical value. It has been proved that under the conditions of the intensified mining operations, the recommended engineering solutions meet the requirements of the well-timed preparation of new extraction pillars. In addition, they are considered as a new tendency to improve current schemes of auxiliary transportation facilities for regional mines and provide operational reliability of the available underground transport equipment.
Patterns of air mixture movement in the operating area for the annular ejector of pneumatic transportation system
Authors: Ponomarenko S. M , Potapchuk I. Yu , Kabakova L. B , Radchenko Yu. M
Published: April 2023

Purpose. To establish the regularities of two-phase flow of “gas-solid particles” in the operating area of an annular ejector where the following processes take place: air mixture ejecting, compressed air outflow from the ejector nozzle, air mixture flows mixing in the transport pipeline. In the work, the velocity distribution is also examined for dispersed phase and air phase of air mixture during its loading and accelerating in the transport pipeline of the pneumatic transport system. Methodology. The research is based on the fundamental approaches of mass point dynamics, aerodynamics, the theory of jet flows and iteration methods of numerical solution of equations. Findings. The mechanics of the air mixture flow under the ejection and aerodynamic force in the operating area of an annular ejector and at the beginning of transport pipeline is analyzed using the method of iterations. The impact of air mixture flow in the operating area of an annular ejector on energy performance of the pneumatic transport system is evaluated. Originality. The originality is that, for the first time, the regularities describing two-phase “gas–solid particles” flow at the loading area of the pneumatic transport system with an annular ejector have been obtained. This made it possible to characterize the velocity distribution of the dispersed and air phases of the air mixture during their loading and aerodynamic acceleration in the transport pipeline. Also, an innovative approach to the effectiveness of the use of pipeline pneumatic transport is the assessment of the energy indicators of the use of ejector-type pneumatic transport equipment depending on the rate of compressed air outflow from the ejector. Practical value. The implementation of the results in the modernization of existing and in the creation of new pneumatic transport systems with an annular ejector makes it possible to increase the efficiency of their use in the technological processes of moving dispersed materials at mining and metallurgical enterprises and in other areas of technology.
Inner shear resistance increasing effect of Concrete Canvas in ballasted railway tracks
Authors: Eller B , Szalai S , Sysyn M , Harrach D , Liu J , Fischer S
Published: April 2023

Purpose. To prove that the GCCM (geosynthetic cementitious composite mat) – type Concrete Canvas (CC) – is an adequate supplementary layer on the top of the subgrade. As its drainage function is known, this article tries to prove the reinforcement possibility. This layer is relatively thin; nevertheless, it can behave like the geogrids. It is the main path to finding out the opportunity of the interlocking effect and its impact on the railway ballast’s inner shear resistance. Methodology. The laboratory measurements were performed in a multi-level shear box, which allows simulating the multi-level shift of the ballast layer. The tests were planned with and without the CC layer. After shearing, the samples were also tested for load-bearing capacity (E2; according to the Hungarian Standard) and particle breakage. On the other hand, the contact surface between the lowest part of the ballast and CC was also measured by a sophisticated 3D laser scanner (GOM ATOS) and graphically by AutoCAD software. Findings. After the results of the laboratory experiments are analyzed, the following parameters are calculated and determined: 1) the reinforcement ratio as the tangent of the inner shear resistance curves in the 5–15 mm horizontal shearing interval as well as the area under graphs by integration in the 0–40 mm interval; 2) the change in load-bearing capacity of the layer-structure with and without CC; 3) the amount of the cement particles; 4) the amount of the broken particles; 5) contact surface between the lowest layer of ballast and CC; 6) flatness of CC sheets after shearing. Based on the results, the Concrete Canvas provides significant reinforcement to the railway ballast. Originality. Any other type of measurement with Concrete Canvas in a multi-level shear box is unknown. The topic is unique. Practical value. In the future, these results may provide baseline data to verify the suitability of the Concrete Canvas in the railway sub- or superstructure for various types of transport.
Social responsibility for the safety and health of employees at work
Authors: Tymoshuk S. V , Pysarevska S. V , Petryshyn R. S , Yaremko Z. M
Published: April 2023

Purpose. To elucidate the role of social responsibility and evaluate the contribution of subjects of labor protection management on business entity in solving problems of maintaining health and ensuring safety of employees in modern occupational conditions. Methodology. Sociological research was carried out by interviewing respondents with various work experience. The obtained results were processed using probability statistical methods with further generalization and formalization. Findings. On the basis of conducted study, it has been established that within the last twenty years the role of subjects of occupational safety management on business entity has been changing gradually, particularly the awareness of employers and employees of their responsibility in labor protection activities has increased; however, the awareness of state authorities for their responsibility in such activities has decreased. According to the obtained results, the formation of high-level occupational safety culture at business entities that include communication based on mutual trust, common perception of the importance of safety and confidence in the effectiveness of preventive measures, is quite actual at the present stage of economic development. The results of the study showed that 82 % of respondents indicated the main problem as a low level of competence of managers and employees in safety issues. Also, the respondents noted problems related to the organization of work (62 % of interviewed persons), including disagreement or misunderstanding of the main goals of the organization. Approximately one third of respondents (32 %) indicated excessive workload. A little more than half of the respondents (61 %) were willing to discuss occupational safety and took an active role in organizing a safe work environment. Originality. Two main reasons were shown why respondents did not wish to discuss occupational safety issues, and as a result to, care about their own safety. The reasons reported were the motives of underestimating occupational hazards and motives related to the professional responsibilities. The identified dominant motives for omission of occupational hazards at work are related to the occupational safety culture. Practical value. The obtained results will contribute to the formation of occupational safety culture, improve labour organization and eliminate the dominant factors of injuries and occupational morbidity. Specific meaning of occupational safety culture and common understanding of it by all members of the workforce plays a fundamental role in accident prevention. The reported results can interest employers and employees, as the main subjects of entrepreneurial activity, that they are fully responsible for their own and collective safety, as well as scientists studying issues related to occupational safety culture.
Mối quan hệ giữa giá vàng, chỉ số thị trường chứng khoán và tỷ giá tại Việt Nam: nghiên
cứu trong bối cảnh đại dịch COVID -19 và xung đột chính trị Nga - Ukraina
Authors: Trần Thị Kim Oanh , Lê Quốc Dĩnh
Published: April 2023

Bài viết nghiên cứu mối tương quan giữa thị trường chứng khoán, giá vàng và tỷ giá USD trong bối cảnh đại dịch COVID-19 và xung đột chính trị Nga-Ukraina. Dữ liệu từ 03/02/2000 đến 10/05/2022, được chia thành 3 giai đoạn: 03/02/2020 đến 22/07/2020 (dịch COVID-19 mới bắt đầu), từ 23/07/2020 đến 23/02/2022 (bắt đầu có ca tử vong vì COVID-19 đầu tiên tại Việt Nam), từ 24/02/2022 đến 10/05/2022 (xung đột chính trị Nga-Ukraina). Bằng mô hình tự hồi quy (VAR), kết quả hàm phản ứng đẩy cho thấy có sự điều chỉnh cấu trúc giữa các thị trường ở các giai đoạn, tồn tại mối quan hệ nghịch chiều giữa thị trường chứng khoán và vàng trong giai đoạn 1 và 3, nhưng mối quan hệ này lại cùng chiều ở giai đoạn 2. Cả ba giai đoạn cho thấy mối quan hệ nghịch chiều giữa giá chứng khoán và tỷ giá, nghịch chiều giữa giá vàng tỷ giá ở giai đoạn 1 và cùng chiều ở giai đoạn 2 và 3. Từ đây bài viết đề xuất các hàm ý chính sách giúp ổn định nền kinh tế Việt Nam.
BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ
Authors: GÜNBATAN Tuğba , MİSER SALİHOĞLU Ece , GÜRBÜZ İlhan , AKAYDIN Sevgi , AKAYDIN Galip
Published: April 2023

Amaç: Bu araştırmada Düzce'de halk ilacı olarak kullanılan yedi bitkinin [Dioscorea communis (L.) Caddick & Wilkin, Mentha longifolia (L.) L. subsp. typhoides (Briq.) Harley, Origanum vulgare L., Rubus ulmifolius Schott, Salvia tomentosa Mill., Thymus longicaulis C.Presl subsp. longicaulis, Trachystemon orientalis (L.) D. Don] üreaz, kimotripsin inhibe edici ve antioksidan aktivitelerinin tespiti amaçlanmıştır.
Gereç ve Yöntem: Bu amaçla bitkilerden metanol ve su ekstreleri hazırlanmıştır. Daha sonra in vitro üreaz ve kimotripsin inhibitör aktiviteleri belirlenmiştir. Ayrıca farklı yöntemlerle antioksidan aktiviteleri (ABTS, CUPRAC, DPPH), toplam fenol ve flavonoit içerikleri de tespit edilmiştir.
Sonuç ve Tartışma: D. communis, O. vulgare, S. tomentosa ve T. longicaulis'in metanol ekstreleri orta düzeyde üreaz inhibitör aktivite (%34.26 ile %44.94 aralığında inhibisyon) gösterirken, diğerlerinde aktivite daha düşük bulunmuştur. En güçlü kimotripsin inhibe edici aktivite R. ulmifolius metanol ekstresi ve T. orientalis su ekstresinde gözlenmiştir (IC50 değerleri sırasıyla 65.32 ve 78.65µg/ml). Genel olarak, çalışılan bitkiler yüksek fenol ve flavonoit içeriklerine uygun olarak yüksek antioksidan aktivite göstermiştir. Sonuç olarak R. ulmifolius ve T. orientalis kuvvetli kimotripsin inhibe edici aktiviteleri ile dikkat çekmiştir. Bu bitkilerin kimotripsin aktivitesi üzerinde daha kapsamlı çalışmaların yapılması gerekmektedir.
Pengaruh Kecepatan Aliran Terhadap Tirai Sayap Beton Pada Pilar Jembatan Dengan Menggunakan RIC:Nays2HD 3.0.
Authors: Karim Nenny , Sukmasari Antaria  , Fenti Daud S  , Hamzah Al Imran
Published: April 2023

Penelitian ini merupakan penelitian uji eksperimental tentang kecepatan aliran disekitar tirai sayap beton sebagai pereduksi gerusan pada pilar jembatan. Tujuan dari penelitian ini adalah menganalisis kecepatan aliran disekitar pilar jembatan sebelum dan sesudah ada tirai sayap beton dengan menggunakan iRIC:Nays2HD 3.0. Penelitian ini menggunakan model saluran tanah dengan penampang bentuk trapezium, model pilar silinder dan model tirai sayap beton. Pengamatan yang dilakukan adalah debit aliran (Q), kecepatan aliran (v), kedalaman aliran (h) dan elevasi kedalaman gerusan (ds) untuk setiap selang waktu tertentu. Hasil simulasi dari penelitian ini menunjukkan kecepatan aliran yang terendah yaitu 0,000 m/s dan tertinggi yaitu 0,998 m/s. Kecepatan aliran yang terjadi di sekitar pilar jembatan dan tirai sayap beton  relatif  kecil disebabkan karena arah aliran yang berubah setelah adanya tirai sayap beton. Gerusan yang terjadi disekitar pilar jembatan relatif kecil disebabkan karena adanya tirai sayap beton di depan pilar. Berdasarkan hasil validasi antara analisa model iRIC:Nays2DH 3.0 dengan model fisik  pada output velocity (ms-1) mempunyai perbedaan yang relatif kecil yaitu sebesar 4.61%.
Factores asociados al bajo peso al nacer a término, Colombia, 2019
Authors: Vásquez Alejo Yenny Zulima
Published: April 2023

Introducción: El bajo Peso al Nacer (BPN) corresponde a peso inferior de 2500 gr en nacidos vivos (NV). La OMS lo considera un problema de salud pública por ser predictor de morbimortalidad prenatal y aumentar riesgo de enfermedades no transmisibles. La meta es reducir a nivel mundial BPN en un 30% al 2025, y en Colombia no superar el 10% Objetivo: identificar los grupos poblacionales con mayor riesgo de presentar bajo peso al nacer a término (BPNT) para el 2019. Materiales y métodos: análisis descriptivo transversal, caracterizando casos notificados de BPNT al Sivigila de 2019, depurando y contrastando con la base de RUAF. Se realizó análisis univariado y bivariado. La proporción de los casos notificados se calculó con relación a la información de NV del DANE 2018. Se estimaron los indicadores definidos por el INS en el protocolo de BPNT. El almacenamiento y análisis se realizó con Excel y con OpenEpi versión 3,01 para estimar los odds ratio (OR) Resultados: Se notificaron 19 436 casos de BPNT con 2,99 casos /100 NV (IC95%: 2,7 - 3,0). La tendencia de este evento entre 2016 - 2019 presentó un aumento porcentual de 9,6 %. El 98 % de los NV recibieron atención institucional, 52 % con 37 semanas de gestación, 93 % por parto simple, una mediana de peso de 2 350 gr. y talla 47 cm. La mayor proporción corresponde al sexo mujer con 3,6 / 100 NV (IC 95%: 2,6 - 3,8) y madres con 50 a 54 años con un 4,8 /100 NV (IC 95%: 3,2 – 4,9), residentes en el área urbana con 3,2/100 NV (IC 95%: 3,1 – 3,2) y no aseguradas al Sistema General de Seguridad Social en Salud con 4,7 /100 NV (IC 95%: 2,1 – 4,8). Se encontraron diferencias significativas en los OR, con mayor riesgo en madres de 45 a 49 años con un OR 1,5 (IC 95%: 1,2 – 2,0. Hubo mayor proporción de casos notificados al Sivigila de BPNT en los departamentos de Cundinamarca, Atlántico y distrito de Bogotá y menor proporción en Caquetá, Barranquilla y Buenaventura. Conclusión: la proporción de BPNT se ha mantenido con relación al 2018, con tendencia al aumento desde el 2016. Los NV corresponden a sexo mujer y de madres “no aseguradas” al SGSSS, los estratos 1 y 2, un nivel educativo de secundaria, así mismo, los grupos de edad extremos mayores de 50 años y menores de 19 años. Se requiere robustecer las políticas públicas debido a las implicaciones a que conlleva a corto y mediano plazo en la mortalidad y el desarrollo psicomotriz de estos menores.
ASSESSING SEISMIC SOIL LIQUEFACTION POTENTIAL USING MACHINE LEARNING APPROACH
Authors: Ramazan Borujerdi Ali
Published: April 2023

The liquefaction vulnerability of soil is generally related to a few soil parameters which are ordinarily measured by laboratory tests on distributed and undistributed tests under distinctive test conditions. This study uses methods based on a standard penetration test to assess liquefaction criteria to appraise the liquefaction vulnerability for soil deposits of Chalus City placed in a high seismic area. To overcome the deficiencies of these experimental strategies an ANN-based model has been created utilizing the Artificial Intelligence technique to anticipate liquefaction. The proposed model is a function of the plasticity index, liquid limit, water content, and some other geotechnical parameters. Reliability index (β) and probability of liquefaction (PL) have also been determined for both the proposed methods for a superior understanding of their accuracies and strength. First-order second moment (FOSM) reliability analysis has been embraced in the present paper. The observation drawn from the study illustrates a reliable and conventional expectation rate of the regression as compared to the experimental strategy. A strong regression shown for assessing the liquefaction vulnerability, which is based on field test information for preparatory prediction, would be of extraordinary help within the field of geotechnical designing.
Meningkatkan Kreativitas Remaja Melalui Motivasi dan Pelatihan pada Remaja Komplek Pesona Pamulang Pondok Petir Depok
Authors: Widya Ambar , Azwina Diana , Khair Oki Iqbal
Published: April 2023

Creativity plays a major role in improving the welfare and quality of human life. Creativity for teenagers is needed because creativity bridges us towards a more advanced future. With creativity, young people can develop their ability to be entrepreneurs in order to open new jobs for the unemployed and young people who have no experience in business or other fields. In this case, we, a team of PKM lecturers from the Management Study Program, Pamulang University, have held a PKM activity with the theme "Increasing Youth Creativity Through Motivation and Training". Solutions to problems that will be carried out in this PKM include preparation, organization, education and training, self-empowerment and integration, implementation and termination. The output targets in this PKM are PKM journals and online news which are expected to contribute to improving the quality of human resources, especially teenagers at the Pesona Pamulang Pondok Petir Complex, Depok RW 15, Pondok Petir Village, Bojongsari District, Depok, West Java.
Teknikundervisning förmedlar flera olika bilder av teknik
Authors: Högström Per , Sparf Maria
Published: April 2023

En studie visar att elever i förskoleklass i sin teknikundervisning fick lära sig en mängd saker om teknikens förhållande till människor, samhälle och natur utöver lektionsinnehållet. Budskap om att teknik ibland även kan påverka människor och miljö negativt var ovanliga.
Smile with diabetes: reflections on illness perception and diabetes management behaviors of adolescents in private health care in South Africa
Authors: Deacon Elmari
Published: April 2023

Background

The association between illness perception and diabetes management has been well established in adults but is not clearly understood for adolescents. This article reflects on qualitative findings on illness perception from the perspective of adolescents, and suggests future research to operationalize findings.

Methods

Qualitative document analysis was conducted on four research projects forming part of the Smile with Diabetes project, which aims to investigate psychosocial variables in diabetes management, including illness perception, within the adolescent and youth populations. Thematic analysis was used to derive four themes from the qualitative and review studies examined in the document analysis.

Results

The voices of the adolescents were evident as four prominent themes: 1) living with diabetes leads to a sense of being different; 2) integration of diabetes into identity is critical, but difficult to achieve; 3) fear of potential negative consequences motivates adherence to treatment; 4) diabetes management is difficult, but possible.

Conclusion

The findings not only confirmed the importance of illness perception in the management of diabetes by adolescents, but also indicate that illness perceptions should be investigated from a developmental perspective, specifically taking identity development into consideration in this group. Adolescents should be made aware of how their thinking about diabetes and its management affects their experience of living with diabetes and its future management. This study further contributes to the literature by focusing on the patient’s voice in understanding living with a chronic condition, and reassures that positive outcomes are possible when living with a chronic condition such as diabetes.
Adjunctive role of Q10 with Ligilactobacillus salivarius, and Lactiplantibacillus plantarum probiotic Bacteria on the HEp-2 cells viability and adhesion of Streptococcus mutans
Authors: Khodaii Zohreh , Mardi Shayan , Mardi Parham , Natanzi Mahboobeh  Mehrabani
Published: April 2023

Objective

Various studies have indicated the application of Coenzyme Q10 and probiotic bacteria such as Ligilactobacillus salivarius (L. salivarius) and Lactiplantibacillus plantarum (L. plantarum) in combating periodontal disease. Considering the positive effect of these two on oral health, and the destructive effect of S. mutans, in this study, we investigate the outcomes of the administration of probiotics and Q10 on infected HEp-2 cell viability and S. mutans adhesion in different settings.

Methods

A 3-week-old human epidermoid laryngeal (HEp-2) cell line was cultured and exposed to two different probiotics and 3 different doses of Q10 doses. Samples were contaminated by S. mutans immediately (therapeutic setting) and after 3 hours (preventive setting). Eventually, the viability of HEp-2 cells was investigated by MTT. Also, the number of adhered S. mutans was explored by direct and indirect adhesion assays.

Results

L. plantarum and L. salivarius protect epithelial cells against S. mutans in both therapeutic and preventive settings, albeit not fully. In contrast, Q10 completely preserves the viability of infected Her HEp-2 cells at all concentrations. The effects of the coexistence of Q10 and probiotics were not quite equal, among which L. salivarius and 5 μg of Q10 form the best results. The microscopic adherence assay of S. mutans revealed that samples containing Q10 had significantly lower adhesion of probiotics and S. mutans to HEp-2 cells. Similarly, plates containing L. salivarius with 5μg or L. plantarum with 1μg Q10 or sole presence of L. salivarius had the lowest S. mutans adherence among others. Also, L. salivarius with 5μg Q10 had one of the highest probiotic adherences.

Conclusion

In conclusion, co-administration of Q10 and probiotics especially in presence of L. salivarius with 5μg Q10 could have remarkable effects on HEp-2 cell viability, S. mutans, and probiotic adherence. Nevertheless, our study, for the first time, showed that Q10 might have an anti-bacterial activity by suppressing the adhesion of tested bacteria to HEp-2 cells. This hypothesis, if correct, suggests that due to their different mechanisms, co-prescription of Q10 and probiotics may lead to better clinical responses, especially in the mentiond dose.
Studies on the contribution of PPAR Gamma to tuberculosis physiopathology
Authors: Díaz Ariana , D’Attilio Luciano , Penas Federico , Bongiovanni Bettina , Massa Estefanía , Cevey Agata , Santucci Natalia , Bottasso Oscar , Goren Nora , Bay María Luisa
Published: April 2023

Introduction

Tuberculosis (TB) is a major health problem characterized by an immuno-endocrine imbalance: elevated plasma levels of cortisol and pro- and anti-inflammatory mediators, as well as reduced levels of dehydroepiandrosterone. The etiological agent, Mycobacterium tuberculosis (Mtb), is captured by pulmonary macrophages (Mf), whose activation is necessary to cope with the control of Mtb, however, excessive activation of the inflammatory response also leads to tissue damage. Glucocorticoids (GC) are critical elements to counteract the immunoinflammatory reaction, and peroxisome proliferator-activated receptors (PPARs) are also involved in this regard. The primary forms of these receptors are PPARϒ, PPARα, and PPARβ/δ, the former being the most involved in anti-inflammatory responses. In this work, we seek to gain some insight into the contribution of PPARϒ in immuno-endocrine-metabolic interactions by focusing on clinical studies in pulmonary TB patients and in vitro experiments on a Mf cell line.

Methods and results

We found that TB patients, at the time of diagnosis, showed increased expression of the PPARϒ transcript in their peripheral blood mononuclear cells, positively associated with circulating cortisol and related to disease severity. Given this background, we investigated the expression of PPARϒ (RT-qPCR) in radiation-killed Mtb-stimulated human Mf. The Mtb stimulation of Mf derived from the human line THP1 significantly increased the expression of PPARϒ, while the activation of this receptor by a specific agonist decreased the expression of pro- and anti-inflammatory cytokines (IL-1β and IL-10). As expected, the addition of GC to stimulated cultures reduced IL-1β production, while cortisol treatment together with the PPARϒ agonist lowered the levels of this proinflammatory cytokine in stimulated cultures. The addition of RU486, a glucocorticoid receptor antagonist, only reversed the inhibition produced by the addition of GC.

Conclusion

The current results provide a stimulating background for further analysis of the interconnection between PPARs and steroid hormones in the context of Mtb infection.
Detection of inguinal lymph nodes is promising for the diagnosis of periprosthetic joint infection
Authors: Qin Leilei , Zhao Chen , Wang Hai , Yang Jianye , Chen Li , Su Xudong , Wei Li , Zhang Tao , Li Jia , Jian Changchun , Hu Ning , Huang Wei
Published: April 2023

Background

Localized inguinal lymphadenopathy often represents lower extremity pathogen infection, while normalized lymphadenopathy is associated with infection regression. We hypothesized that inguinal lymph nodes (LNs) were enlarged in Periprosthetic Joint Infection (PJI) patients and that normalized inguinal LNs would be a promising way to determine the timing of reimplantation.

Methods

We prospectively enrolled 176 patients undergoing primary and revision hip or knee arthroplasty. All patients underwent ultrasound examination of inguinal LNs preoperatively. The diagnostic value of inguinal LNs in PJI was evaluated by the receiver operating characteristic (ROC) curve.

Results

The median level of inguinal LNs was 26mm in the revision for PJI group compared with 12 mm in the aseptic revision group (p< 0.0001). The size of the inguinal LNs well distinguishes PJI from aseptic failure (AUC= 0.978) compare with ESR (AUC= 0.707) and CRP (AUC= 0.760). A size of 19mm was determined as the optimal threshold value of the inguinal LNs for the diagnosis of PJI, with a sensitivity of 92% and specificity of 96%.

Conclusion

Ultrasonic analysis of inguinal LNs is a valuable piece of evidence for the diagnosis of PJI and evaluation of persistent infection.
Serum metabolomic profiles in BALB/c mice induced by Babesia microti infection
Authors: Shen Liang , Wang Chunhua , Wang Ruilin , Hu Xue , Liao Shiying , Liu Wentong , Du Aoling , Ji Shengwei , Galon Eloiza May , Li Hang , Xuan Xuenan , Xiao Juan , Liu Mingming
Published: April 2023

Introduction

The protozoan parasite Babesia microti is the primary cause of human babesiosis. This parasite invades and multiplies inside red blood cells (RBCs), and infections differ significantly based on the age and immune competency of the host. The aim of this study was to investigate the use of serum metabolic profiling to identify systemic metabolic variations between B. microti-infected mice and noninfected controls.

Methods

A serum metabolomics analysis of BALB/c mice that had been intraperitoneally injected with 107B. microti-infected RBCs was performed. Serum samples from the early infected group (2 days postinfection), the acutely infected group (9 days postinfection), and the noninfected group were collected and evaluated using a liquid chromatography−mass spectrometry (LC−MS) platform. Principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA) identified metabolomic profiles that differentiated the B. microti-infected and noninfected groups.

Results

Our results confirm that the serum metabolome is significantly influenced by acute B. microti infection and show that infection results in dysregulation of metabolic pathways and perturbation of metabolites. Acutely infected mice displayed perturbations in metabolites associated with taurine and hypotaurine metabolism, histidine metabolism, and arachidonic acid metabolism. Taurocholic acid, anserine, and arachidonic acid may be potential candidates as serological biomarkers for diagnosing B. microti infection at the acute stage. These metabolites could be further examined for their role in disease complexity.

Discussion

Our findings demonstrate that the acute stage of B. microti infection induces abnormalities in the metabolites present in mouse serum and provide new insight into the mechanisms involved in systemic metabolic changes that occur during B. microti infection.
Towards realistic privacy-preserving deep learning over encrypted medical data
Authors: Cabrero-Holgueras José , Pastrana Sergio
Published: April 2023

Cardiovascular disease supposes a substantial fraction of healthcare systems. The invisible nature of these pathologies demands solutions that enable remote monitoring and tracking. Deep Learning (DL) has arisen as a solution in many fields, and in healthcare, multiple successful applications exist for image enhancement and health outside hospitals. However, the computational requirements and the need for large-scale datasets limit DL. Thus, we often offload computation onto server infrastructure, and various Machine-Learning-as-a-Service (MLaaS) platforms emerged from this need. These enable the conduction of heavy computations in a cloud infrastructure, usually equipped with high-performance computing servers. Unfortunately, the technical barriers persist in healthcare ecosystems since sending sensitive data (e.g., medical records or personally identifiable information) to third-party servers involves privacy and security concerns with legal and ethical implications. In the scope of Deep Learning for Healthcare to improve cardiovascular health, Homomorphic Encryption (HE) is a promising tool to enable secure, private, and legal health outside hospitals. Homomorphic Encryption allows for privacy-preserving computations over encrypted data, thus preserving the privacy of the processed information. Efficient HE requires structural optimizations to perform the complex computation of the internal layers. One such optimization is Packed Homomorphic Encryption (PHE), which encodes multiple elements on a single ciphertext, allowing for efficient Single Instruction over Multiple Data (SIMD) operations. However, using PHE in DL circuits is not straightforward, and it demands new algorithms and data encoding, which existing literature has not adequately addressed. To fill this gap, in this work, we elaborate on novel algorithms to adapt the linear algebra operations of DL layers to PHE. Concretely, we focus on Convolutional Neural Networks. We provide detailed descriptions and insights into the different algorithms and efficient inter-layer data format conversion mechanisms. We formally analyze the complexity of the algorithms in terms of performance metrics and provide guidelines and recommendations for adapting architectures that deal with private data. Furthermore, we confirm the theoretical analysis with practical experimentation. Among other conclusions, we prove that our new algorithms speed up the processing of convolutional layers compared to the existing proposals.
Plant phylogenetic relatedness and herbivore specialization interact to determine pest biocontrol efficiency in mixed plantations
Authors: Yang Qingqing , Chen Xiaohua
Published: April 2023

Pest herbivory regulation is one of the key functions provided by diverse ecosystems, especially when compared to species depauperate agro-ecosystems and in the context of increased pest outbreaks due to global change. The dilution effect of host diversity on insect herbivory suggests that mixed plantations are feasible for regulating pest herbivory in agroecosystems. Dilution effect of increased plant diversity on insect herbivory has been widely observed, yet little is known about how it may change with plant phylogenetic relatedness and herbivore specialization, especially at the community level. Here, we compared herbivore richness, abundance, and degree of herbivory (i.e., the ratio of trees damaged by pest and total trees in a given area) among the two monocultures and the four mixed plantations in Wenchang city, Hainan Province, China. We also respectively assessed the effects of phylogenetically close or distant species on generalist and specialist herbivores in monocultures and mixture. We found that increasing the number of phylogenetically closely-related tree species could dilute generalist herbivore richness, abundance, and degree of herbivory but amplify specialist herbivore richness, abundance, and degree of herbivory. In contrast, increasing the number of phylogenetically distant tree species increased generalist herbivore richness, abundance, and degree of herbivory, while reducing specialist herbivore richness, abundance, and degree of herbivory. Our results suggest that plant phylogenetic relatedness and herbivore specialization can indeed interact to influence pest control efficiency when using mixed plantations to manage pest herbivory in agroecosystems. Thus, both herbivore specialization and plant phylogenetic relatedness should be taken into account in the management of agro-ecosystems and biodiversity conservation with respect to herbivory.
Altitudinal gradient drives significant changes in soil physico-chemical and eco-physiological properties of Rhododendron anthopogon: a case study from Himalaya
Authors: Mangral Zahid Ahmed , Islam Shahid Ul , Tariq Lubna , Kaur Sharanjeet , Ahmad Rameez , Malik Akhtar H. , Goel Shailendra , Baishya Ratul , Barik Saroj Kanta , Dar Tanvir Ul Hassan
Published: April 2023

The best natural laboratories for studying the ecological responses of plants are high-altitude areas like the Himalaya, where many gradients coexist on a relatively small spatial scale. Here, we investigate the effect of soil physico-chemical and eco-physiological properties on the broadleaf evergreen woody shrub Rhododendron anthopogon D.Don along an altitudinal gradient in the Kashmir Himalaya. We collected leaf and soil samples for eco-physiological and soil physico-chemical analysis, respectively, at five different sites along an altitudinal gradient (3,220–3,908 m). Our results demonstrate a significant difference between soil physico-chemical and eco-physiological parameters along the altitudinal gradient. A significant correlation was observed between different studied parameters and altitude. Principal component analysis of studied soil physico-chemical and eco-physiological parameters revealed that all the sites were grouped into four clusters according to altitude, suggesting a more pronounced effect of altitude. Our findings showed that soil infiltration capacity increased with altitude, which would be helpful for the growth and development of R. anthopogon. We also observed significant variations in eco-physiological parameters, demonstrating their critical involvement in adapting R. anthopogon to the harsh environment of the alpine regions of Kashmir Himalaya. Therefore, the present study adds to our understanding that R. anthopogon has sufficient soil physico-chemical and eco-physiological plasticity, which should be favorable for its survival in future climates, offering an adaptive advantage and expanding its range shortly.
The effects of displaying availability sections of an automated driving function
Authors: Danner Simon , Feierle Alexander , Gary Sebastian , Bengler Klaus
Published: April 2023

So far, there has been little research into displaying the availability of a higher-level automated driving system. The benefits of presenting availability times while driving automatically have already been discussed, but there are no findings on giving information on all availability sections (operational design domains) independent of the current state of the automated driving system. This work aims to close this gap by conducting a driving simulator study with N = 54 participants to verify whether an overview display of all the road sections on which automated driving is possible has a positive effect on the participants’ acceptance, usability, workload, and task performances. Results showed that the presentation of this additional information had a significantly positive influence on both acceptance and task performance. The outcomes of this work indicate that the required transparency-creating information of the automated driving system should not be limited to safety-related information or the phases of automated driving itself.
Characterization of post-vaccination SARS-CoV-2 T cell subtypes in patients with different hematologic malignancies and treatments
Authors: Pfannes Roald , Pierzchalski Arkadiusz , Maddalon Ambra , Simion Alexandra , Zouboulis Christos C. , Behre Gerhard , Zenclussen Ana Claudia , Westphal Sabine , Fest Stefan , Herberth Gunda
Published: April 2023

Background

To evaluate the benefits of SARS-CoV-2 vaccination in cancer patients it is relevant to understand the adaptive immune response elicited after vaccination. Patients affected by hematologic malignancies are frequently immune-compromised and show a decreased seroconversion rate compared to other cancer patients or controls. Therefore, vaccine-induced cellular immune responses in these patients might have an important protective role and need a detailed evaluation.

Methods

Certain T cell subtypes (CD4, CD8, Tfh, γδT), including cell functionality as indicated by cytokine secretion (IFN, TNF) and expression of activation markers (CD69, CD154) were assessed via multi-parameter flow cytometry in hematologic malignancy patients (N=12) and healthy controls (N=12) after a second SARS-CoV-2 vaccine dose. The PBMC of post-vaccination samples were stimulated with a spike-peptide pool (S-Peptides) of SARS-CoV-2, with CD3/CD28, with a pool of peptides from the cytomegalovirus, Epstein-Barr virus and influenza A virus (CEF-Peptides) or left unstimulated. Furthermore, the concentration of spike-specific antibodies has been analyzed in patients.

Results

Our results indicate that hematologic malignancy patients developed a robust cellular immune response to SARS-CoV-2 vaccination comparable to that of healthy controls, and for certain T cell subtypes even higher. The most reactive T cells to SARS-CoV-2 spike peptides belonged to the CD4 and Tfh cell compartment, being median (IQR), 3.39 (1.41-5.92) and 2.12 (0.55-4.14) as a percentage of IFN- and TNF-producing Tfh cells in patients. In this regard, the immunomodulatory treatment of patients before the vaccination period seems important as it was strongly associated with a higher percentage of activated CD4 and Tfh cells. SARS-CoV-2- and CEF-specific T cell responses significantly correlated with each other. Compared to lymphoma patients, myeloma patients had an increased percentage of SARS-CoV-2-specific Tfh cells. T-SNE analysis revealed higher frequencies of γδT cells in patients compared to controls, especially in myeloma patients. In general, after vaccination, SARS-CoV-2-specific T cells were also detectable in patients without seroconversion.

Conclusion

Hematologic malignancy patients are capable of developing a SARS-CoV-2-specific CD4 and Tfh cellular immune response after vaccination, and certain immunomodulatory therapies in the period before vaccination might increase the antigen-specific immune response. A proper response to recall antigens (e.g., CEF-Peptides) reflects immune cellular functionality and might be predictive for generating a newly induced antigen-specific immune response as is expected after SARS-CoV-2 vaccination.