bluuebunny/crossref_metadata_2025 huggingface dataset:
Halal value chain: a structured literature review and meta-analysis
Authors: Harsanto Budi , Pradana Mahir , Yunani Akhmad , Firmansyah Egi Arvian , Apriliadi Ardi , Farras Joval Ifghaniyafi , Nabila Farizka Shafa
Published: December 2024

Purpose

This study aims to provide a comprehensive review of published research on the halal value chain (HVC) that is accessible through the Scopus database.

Design/methodology/approach

A corpus of 120 research papers that were indexed by Scopus underwent an extensive investigation. The authors used the bibliometrix program and the VOSviewer software to analyze and visualize the exported data.

Findings

The results suggest a rise in scholarly investigations carried out in this specific domain, with “food supply,” “decision-making” and “supply chain management” as the most frequent emerging terms. This study contributes to the existing study by clarifying the connections between the supply chain and the HVC and setting future research directions.

Originality/value

This study makes a substantial contribution by defining a new area of academic study and establishing a previously unidentified link between the literature of halal logistics, halal supply chain and the HVC.
The impact of knowledge attributes and life cycle on the evolution of emerging technology innovation network: a TERGM analysis
Authors: Liu Yaqin , Yu Qian , Li Jing
Published: December 2024

Purpose

This study aims to explore the factors influencing the evolution of emerging technology innovation network (ETIN) in combination with the key attributes and life cycle of emerging technologies, particularly the impact of multiple knowledge attributes and technology life cycle on the ETIN evolution.

Design/methodology/approach

This study collects 5G patent data and their citation information from the Derwent Innovations Index to construct a 5G technology innovation network (5GIN) as a sample network and conducts an empirical analysis of the 5GIN using the temporal exponential random graph model (TERGM).

Findings

The results indicate that during the 5GIN evolution, the network scale continues to expand and exhibits increasingly significant core-periphery structure, scale-free characteristic, small-world characteristic and community structure. Furthermore, the findings suggest that the multiple knowledge attributes based on the key attributes of emerging technologies, including knowledge novelty, coherence, growth and impact, have a significant positive influence on the ETIN evolution. Meanwhile, the temporal evolution of ETIN is also found to be correlated with the life cycle of emerging technologies.

Originality/value

This study extends the exploration of emerging technology research from a complex network perspective, providing a more realistic explanatory framework for the factors influencing ETIN evolution. It further highlights the important role that multiple knowledge attributes and the technology life cycle play within this framework.
Limited enzymatically hydrolyzed pea protein–inulin interactions in gel systems
Authors: Sawant Sanjana , Alvarez Valente B. , Heldman Dennis R.
Published: December 2024

Gelation of protein‐polysaccharide mixtures can help create a variety of distinctive gel systems as compared to single polysaccharide or protein gels. The properties of these functional gels are heavily reliant upon the nature of protein‐polysaccharides interactions, their gelling compatibility, and mechanism. Pea protein isolate dispersions (7.5%) were subjected to limited enzymatic hydrolysis using the enzyme Alcalase® at three hydrolysis times (0, 3, and 6 min). Inulin was added according to three ratios (0, 1:4, and 2:4) with pea protein. Viscoelastic properties of the gels formed were measured using amplitude sweep and frequency sweep. Storage modulus (G′) measurements from the amplitude sweep indicated that samples hydrolyzed for 3 min with 1:4 ratio of inulin to pea protein had maximum gel strength, exhibiting G′ values of ∼307 Pa. G′ values for samples hydrolyzed for 0 and 6 min with different inulin ratios averaged ∼13 and ∼144 Pa, respectively. Confocal laser scanning microscopy showed that gels developed by samples hydrolyzed for 3 min showed a dense network as compared to an open network in gels formed by samples hydrolyzed for 6 min, whereas large random aggregates were observed in gels formed by samples hydrolyzed for 0 min. The study confirmed that inulin promotes noncovalent bond formation in samples hydrolyzed for 3 min with a 1:4 inulin ratio, shown by an ∼18% increased protein solubility in urea. Additionally, collaboration between noncovalent bonds and disulfide linkages stabilized the gel structure, as indicated by further increase in solubility in combination of urea and Dithiothreitol.

Practical Application

Plant proteins are gaining attention as alternatives to animal proteins. However, they have inferior functionality, which affects their applicability in food products. This investigation aimed to evaluate enzymatic hydrolysis to enhance the structural and functional properties of pea proteins, thus increasing their applicability in the food industry. Inulin is an oligosaccharide and soluble fiber, which promotes gut health. Thus, gels combining hydrolyzed pea protein and inulin can serve as a model mixed food system of interest to both the industry and consumers.
Human Papillomavirus Infection and Autoimmune Diseases: A Two‐Sample Bidirectional Mendelian Randomization Study
Authors: He Tian , Fang Xi , Hu Xiao , Chen Cong , Zhang Peng , Ge Man , Xu Yi‐Qing , Gao Zhao‐Xing , Wang Peng , Wang De‐Guang , Pan Hai‐Feng
Published: December 2024

Background

Although earlier observational studies have revealed a connection between human papillomavirus (HPV) infection and several autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), the exact causative mechanism underlying this association is still unknown.

Methods

This two‐sample bidirectional MR study was conducted based on publicly released data from genome‐wide association studies (GWAS). Our results were mainly derived from the inverse variance weighted (IVW) model, with the remaining three models also being calculated. The MR Steiger test was used to examine the correctness of our causal direction. Sensitivity analysis was performed using Mendelian randomized pleiotropy residual sum and outlier (MR‐PRESSO), MR‐Egger regression.

Results

The IVW results showed that there was a positive causal association between HPV16 E7 protein and SLE (odds ratio (OR) = 1.075, 95% confidence interval (CI), 1.003–1.151, FDR‐p = 0.04), however, there was a negative causal association between HPV18 E7 protein and SLE (OR = 0.884, 95% CI, 0.804–0.972, FDR‐p = 0.02). No causal associations of HPV16 E7 protein and HPV18 E7 protein with RA, IBD was observed including its subtypes Ulcerative colitis (UC) and Crohn's disease (CD). Sensitivity analysis showed that there was no significant heterogeneity (p > 0.05) or genetic pleiotropy (p > 0.05).

Conclusion

Our two‐sample bidirectional Mendelian randomization study identifies a causal association between HPV infection and SLE, but no causal association between HPV infection and RA and IBD.
Influence of inoculum‐to‐substrate ratio on biomethane production via anaerobic digestion of biomass
Authors: Valentin Marvin T. , Ciolkosz Daniel , Białowiec Andrzej
Published: December 2024

The influence of the inoculum‐to‐substrate ratio (ISR) on anaerobic digestion (AD) of biomass in terms of methane yield and microbial community, was explored in this paper. The level of ISR can affect the AD performance in several ways. At extremely low ISR, volatile fatty acids (VFAs) accumuate, while inhibition occur at higher level of ISR. An ISR ranging from 1.0–2.0 was found optimal resulting in higher methane yield, organic matter removal and VFA degradation. Furthermore, a high ISR (2.0–4.0) is favourable to methanogenesis, while a lower ISR (<1.0) is prone to irreversible acidification. The range of ISR can shift the methanogenic pathway of AD to favour an acetoclastic or hydrogenotrophic response, indicated by the enriched group of microorganisms. The genus Methanosaeta (acetoclastic) and Methanobacterium (hydrogenotrophic) are the most enriched methanogens across all ISRs, while Firmicutes, Bacteroidetes, Proteobacteria and Spirochaetae are dominant in the bacterial community. Additionally, the interplay of substrate biodegradability and ISR potentially affects AD performance. Finally, novel equations are developed and proposed for characterizing the quantity of inoculum and substrate.
Adjuvant Radiotherapy After Surgical Resection Improves Local Control in Adrenocortical Carcinoma
Authors: Zhu Jiawei , Yan Ruiyi , Shen Jing , Miao Zheng , Shen Jie , Hu Ke , Zhang Fuquan
Published: December 2024

Aims

Adrenocortical carcinoma is a rare cancer known for its high recurrence rate. This study aimed to evaluate the effects of postoperative adjuvant radiotherapy on the outcomes of patients with adrenocortical carcinoma.

Methods

We examined patients with adrenocortical carcinoma who had undergone curative tumor resection. Tumor stages were classified using the European Network for the Study of Adrenal Tumors staging system. Out of 131 patients, 15 underwent adjuvant radiotherapy. Patients who underwent surgery and adjuvant radiotherapy were compared with those who underwent surgery only.

Results

Baseline characteristics were similar between the adjuvant radiotherapy (n = 15) and control groups (n = 30). Local recurrence occurred in three patients (20%) who received adjuvant radiotherapy and 18 patients (60%) in the control group (p < 0.05). The estimated 3‐year locoregional‐free survival was significantly higher in the adjuvant radiotherapy group (77%) compared to the control group (38.1%, p < 0.05). However, there were no significant differences in recurrence‐free or overall survival between the two groups.

Conclusions

Postoperative adjuvant radiotherapy significantly enhances local control of adrenocortical carcinoma. It should be considered a crucial component of treatment, particularly for patients at high risk of recurrence.
Clinical Trial: Treatment of Functional Dyspepsia According to Subtype Compared With Empirical Proton Pump Inhibitor
Authors: Chuah Kee Huat , Loo Qing Yuan , Hian Wen Xuan , Khoo Xin Hui , Panirsheeluam Sarala , Jubri Nurhidayah Binti Mohammad , Natarajan Vicraman , Khoo Stanley , Mahadeva Sanjiv
Published: December 2024

Background

International guidelines recommend contrasting initial treatment strategies for functional dyspepsia (FD).

Aims

To evaluate the efficacy and safety of treatment according to subtypes, compared with empirical proton pump inhibitor (PPI), in the initial treatment of FD.

Methods

We performed a single‐blinded, randomised controlled trial of adults with FD. In the intervention group (treatment according to subtype), patients were categorised into epigastric pain syndrome (treatment esomeprazole); postprandial distress syndrome (PDS; treatment itopride) and overlap (treatment itopride, maintain, add/or switch to esomeprazole at week 4). The control group received esomeprazole only. The primary efficacy outcome was the assessment of global symptom improvement (primary end point: best two points from the 7‐point Likert scale) over 8 weeks. Secondary outcomes included assessment of the change in nine individual upper gastrointestinal symptoms, quality of life (Short‐Form Nepean Dyspepsia Index) and adverse events.

Results

We randomised 180 patients (median age: 50; 68.7% female 56.7% PDS) 1:1 into intervention and control arms. The percentage of patients achieving the primary efficacy outcome were 74.4% and 72.2%, respectively (p = 0.74). The improvement of individual symptoms in both groups were similar. The SF‐NDI improved after treatment in both groups (p < 0.001) but there was no significant difference in the degree of change between groups. Rates of adverse events between groups were similar at week 8.

Conclusion

Initial treatment of FD according to subtype was not more effective than empirical PPI alone for up to 8 weeks. Further multicentre studies, with a larger sample size, are recommended to validate these findings.

Trial Registration: ClinicalTrials.gov identifier: NCT04918017
Birds of a Feather Flock Together: The Impact of Top Management Team Faultlines on Environmental, Social, and Governance Performance
Authors: Huang Hai , Hao Shengbin
Published: December 2024

While theory and research indicate that top management team (TMT) attributes play a crucial role in shaping responsible practices, how and when TMT faultlines affect environmental, social, and governance (ESG) performance remains an open question. This study aims to fill this research gap by integrating social categorization theory with the faultline literature. Using a sample of Chinese listed firms over a 12‐year period, our findings indicate that TMT faultlines can significantly inhibit ESG performance, and managerial myopia is the primary channel through which the negative effect operates. In addition, our study reveals that negative attainment discrepancy significantly amplifies the inhibitory effect of TMT faultlines on ESG performance. Intriguingly, this inhibitory effect is mitigated in firms with strong Confucian culture. Our study also reveals variations in the impact of TMT faultlines on ESG performance concerning the type of faultlines and the level of industry competition. These findings not only contribute to the literature on TMT faultlines and upper echelons but also provide valuable guidance for managers in adeptly navigating the dynamics of TMT composition.
Is climate change to blame? Increased rainfall reduces emergence of Taiwanosemia hoppoensis (Hemiptera: Cicadidae) in coastal windbreak forests
Authors: Chang Yuan‐Mou , Kao Chung‐Jui , Hsu Chia‐Hsuan , Huang Shu‐Ping , Hatch Kent A. , Hsieh Chih‐Hao , Chen Jian‐Hong , Chen Kai‐Wei , Mei Hui‐Lin , Hwang Wenbe
Published: December 2024

We found that increased rainfall reduced exuvial numbers and impacted populations of Taiwanosemia hoppoensis from coastal regions, likely due to prolonged soil flooding harming the subterranean nymphs. As climate change advances, long‐term monitoring is essential to track cicada populations across taxa and regions, given their important ecological roles.

Abstract in Chinese is available with online material.
Prolonged venous transit is associated with lower odds of excellent recovery after reperfusion in anterior large‐vessel occlusion stroke
Authors: Salim Hamza Adel , Lakhani Dhairya A. , Mei Janet , Luna Licia , Shahriari Mona , Hyson Nathan Z. , Deng Francis , Dmytriw Adam A. , Guenego Adrien , Urrutia Victor C. , Marsh Elisabeth B. , Lu Hanzhang , Xu Risheng , Leigh Rich , Wolman Dylan , Shah Gaurang , Pulli Benjamin , Albers Gregory W. , Hillis Argye E. , Llinas Rafael , Nael Kambiz , Wintermark Max , Heit Jeremy J. , Faizy Tobias D. , Yedavalli Vivek
Published: December 2024

Background and purpose

Acute ischemic stroke due to anterior circulation large‐vessel occlusion (AIS‐LVO) remains a leading cause of disability despite successful reperfusion therapies. Prolonged venous transit (PVT) has emerged as a potential prognostic imaging biomarker in AIS‐LVO. We aimed to investigate whether PVT is associated with a decreased likelihood of excellent functional outcome (modified Rankin Scale [mRS] score of 0–1 at 90 days) after successful reperfusion.

Methods

In our prospectively collected, retrospectively reviewed database, we analyzed data from 104 patients with AIS‐LVO who achieved successful reperfusion (modified Thrombolysis in Cerebral Infarction score of 2b/2c/3) between September 2017 and September 2022. PVT was defined as a time to maximum (Tmax) of ≥10 s in the superior sagittal sinus and/or torcula on computed tomography perfusion (CTP) imaging. Patients were categorized into PVT‐positive (PVT+) and PVT‐negative (PVT–) groups. The primary outcome was excellent functional recovery at 90 days.

Results

Of the 104 patients, 30 (29%) were PVT+. Excellent functional outcome was achieved in 38 patients (37%). PVT+ patients had a significantly lower rate of excellent recovery compared to PVT– patients (11% vs. 39%; p < 0.001). After adjusting for possible confounders, PVT positivity was independently associated with lower odds of excellent recovery (adjusted odds ratio 0.11, 95% confidence interval 0.02 to 0.48; p = 0.006).

Conclusions

Among patients with AIS‐LVO who achieved successful reperfusion, PVT positivity was independently associated with a decreased likelihood of excellent functional outcome at 90 days. Assessment of PVT on CTP may provide valuable prognostic information and aid in clinical decision making for patients with AIS‐LVO.
Genome‐Wide Diversity in Lowland and Highland Maize Landraces From Southern South America: Population Genetics Insights to Assist Conservation
Authors: Dominguez Pia Guadalupe , Gutierrez Angela Veronica , Fass Monica Irina , Filippi Carla Valeria , Vera Pablo , Puebla Andrea , Defacio Raquel Alicia , Paniego Norma Beatriz , Lia Veronica Viviana
Published: December 2024

Maize (Zea mays ssp. mays L.) landraces are traditional American crops with high genetic variability that conform a source of original alleles for conventional maize breeding. Northern Argentina, one the southernmost regions of traditional maize cultivation in the Americas, harbours around 57 races traditionally grown in two regions with contrasting environmental conditions, namely, the Andean mountains in the Northwest and the tropical grasslands and Atlantic Forest in the Northeast. These races encounter diverse threats to their genetic diversity and persistence in their regions of origin, with climate change standing out as one of the major challenges. In this work, we use genome‐wide SNPs derived from ddRADseq to study the genetic diversity of individuals representing the five groups previously described for this area. This allowed us to distinguish two clearly differentiated gene pools, the highland northwestern maize (HNWA) and the floury northeastern maize (FNEA). Subsequently, we employed essential biodiversity variables at the genetic level, as proposed by the Group on Earth Observations Biodiversity Observation Network (GEO BON), to evaluate the conservation status of these two groups. This assessment encompassed genetic diversity (Pi), inbreeding coefficient (F) and effective population size (Ne). FNEA showed low Ne values and high F values, while HNWA showed low Ne values and low Pi values, indicating that further genetic erosion is imminent for these landraces. Outlier detection methods allowed identification of putative adaptive genomic regions, consistent with previously reported flowering‐time loci and chromosomal regions displaying introgression from the teosinte Zea mays ssp. mexicana. Finally, species distribution models were obtained for two future climate scenarios, showing a notable reduction in the potential planting area of HNWA and a shift in the cultivation areas of FNEA. These results suggest that maize landraces from Northern Argentina may be unable to cope with climate change. Therefore, active conservation policies are advisable.
Exploring the Mediating Role of EFL Teachers’ Emotion Regulation in the Relationship Between Emotional Intelligence and Resilience
Authors: Liu Honggang , Liu Baochen , Zhou Xueheng
Published: December 2024

Research on English as a foreign language (EFL) teachers’ psychology has been increasingly focusing on emotional intelligence (EI), emotion regulation (ER) and resilience due to the significant challenges these teachers face. However, the complex relationships among these three variables in the EFL teaching field have received scant attention. To address this gap, this study was conducted to test hypotheses regarding the relationships between EI, ER and resilience and the mediating role of ER. A survey was administered to 1017 junior high school EFL teachers from mainland China using three distinct scales to assess their levels of EI, ER and resilience. The data were analysed using SPSS 26.0 and Amos 24.0. The findings revealed that the EFL teachers demonstrated high levels of EI, ER and resilience. Furthermore, structural equation modelling showed that EI significantly predicted resilience, and cognitive reappraisal in ER significantly mediated this relationship. These results emphasize the importance of cultivating EI in enhancing EFL teachers’ psychological well‐being. Evidently, EI is a key factor in improving teacher resilience, and ER plays a crucial mediating role in this process, thereby enabling them to address professional challenges.
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity
Authors: Parthun Michael , Long Matthew E. , Hemann Emily A.
Published: December 2024

The sensing of nucleic acids by DEAD/H‐box helicases, specifically retinoic acid‐inducible gene I (RIG‐I) and melanoma differentiation‐associated protein 5 (MDA5), plays a critical role in inducing antiviral immunity following infection. However, this DEAD/H‐box helicase family includes many additional proteins whose immune functions have not been investigated. While numerous DEAD/H‐box helicases contribute to antiviral immunity, they employ diverse mechanisms beyond the direct sensing of nucleic acids. Some members have also been identified to play proviral (promoting virus replication/propagation) roles during infections, regulate other non‐viral infections, and contribute to the regulation of autoimmunity and cancer. This review synthesizes the known and emerging functions of the broader DEAD/H‐box helicase family in immune regulation and highlights ongoing efforts to target these proteins therapeutically.
Erasing History as a Form of Defensive Forgetting
Authors: Berninger Anja
Published: December 2024

It has sometimes been suggested that removing statues of problematic historical figures such as Cecil Rhodes from the public realm amounts to ‘erasing history’ and should therefore be avoided. In philosophy, this approach has generally been rejected. In this article, I try to develop a more plausible version of the erasing history argument. I suggest that sometimes societies aim to forget for defensive reasons (i.e. to cover up past wrongdoing). I also suggest that such past wrongdoing can also consist in the widespread acceptance of a problematic monument (and therewith complicity in the insult it represents). I conclude that in such cases, to avoid defensive forgetting, we should aim to recontextualize rather than remove the monument. I also discuss which forms such recontextualization may take.
No associations between neuroborreliosis in children and psychiatric neurodevelopmental disorders: a nationwide, population‐based, matched cohort study
Authors: Tetens Malte M. , Graham Emma E. , Andersen Nanna S. , Bangsborg Jette , Bodilsen Jacob , Dessau Ram B. , Ellermann‐Eriksen Svend , Jørgensen Charlotte Sværke , Møller Jens Kjølseth , Nielsen Alex Christian Yde , Pedersen Michael , Søgaard Kirstine K. , Obel Dorrit , Nygaard Ulrikka , Obel Niels , Lebech Anne‐Mette , Omland Lars Haukali
Published: December 2024

Background

It has been suggested that neuroborreliosis in children can manifest as psychiatric neurodevelopmental disorders or cause long‐term neurodevelopmental sequelae. However, previous studies were limited by size and design.

Methods

We performed a nationwide, population‐based, matched cohort study in Denmark between 1995 and 2021. We included all Danish residents <16 years old with a positive Borrelia burgdorferi sensu lato intrathecal antibody index test (children with neuroborreliosis). To form a comparison cohort, we randomly extracted individuals from the general population matched on date of birth and sex 10:1 to children with neuroborreliosis. We calculated hazard ratios (HRs) with 95% CIs of contact to departments of psychiatry, diagnosis of attention deficit disorder, diagnosis of learning or intellectual developmental disorders, or receipt of psychostimulants for attention deficit disorder among children with neuroborreliosis compared with comparison cohort members. We did a sensitivity analysis in the form of a case‐control study, where we examined whether these outcomes were more frequent among children with neuroborreliosis than in the comparison cohort before study inclusion to account for differential delay in diagnosis.

Results

We included 1,132 children with neuroborreliosis and 11,320 comparison cohort members with an observation time of 168,858 person‐years. We found no associations between neuroborreliosis and contact with departments of psychiatry (HR: 1.0, 95% CI 0.9–1.2), diagnosis of attention deficit disorder (HR: 0.9, 95% CI 0.6–1.3), diagnosis of learning or intellectual developmental disorders (HR 0.8, 95% CI 0.5–1.4), or receipt of psychostimulants for attention deficit disorder (HR: 0.8, 95% CI 0.6–1.1). Also, in the sensitivity analyses, these outcomes were not more present among children with neuroborreliosis than in the comparison cohort before study inclusion.

Conclusions

Our results do not support that neuroborreliosis in children manifests as psychiatric neurodevelopmental disorders or causes long‐term neurodevelopmental sequelae.
2024 European guidelines for the management of genital herpes
Authors: Patel Rajul , Moran Benjamin , Clarke Emily , Geretti Anna Maria , Lautenschlager Stephan , Green John , Donders Gilbert , Gomberg Mikhail , Samraj Shyam , Tiplica George Sorin , Foley Elizabeth
Published: December 2024

Genital herpes is one of the most common sexually transmitted infections worldwide. Using the best available evidence, this guideline recommends strategies for diagnosis, management and follow‐up of the condition as well as for minimizing transmission. Early recognition and initiation of therapy is key and may reduce the duration of illness or avoid hospitalization with complications, including urinary retention, meningism or severe systemic illness. The guideline covers a range of common clinical scenarios, such as recurrent genital herpes, infection during pregnancy and coinfection with human immunodeficiency virus.
“Çété méné endan Lalwizyann”: The role of Haiti in representations of Louisiana Creole language and identity
Authors: Wendte Nathan A.
Published: December 2024

Misconceptions about the ethnolinguistic relationship between Haiti and Louisiana persist to the present. Central to this debate is whether Louisiana Creole (LC) is a variety of French, an independent language, or a variant of the better‐known and more widely spoken Haitian Creole (HC). In this paper, I present data from residents of Louisiana and the greater Gulf South who invoke Haiti in reference to who and what are Creoles. Haiti surfaces in two primary ways: as a site of origin and authentication or as a site of difference and denaturalization. Haiti's indexical value and authenticating potential vary according to a speaker's ethnolinguistic identity. These complexities are particularly important for understanding the history and trajectory of the current reclamation movement for the Louisiana Creole language (aka “Kouri‐Vini”).
An Integrative Review of Exclusive Breast Milk Expression
Authors: Rosenbaum Kimberly , McAlister Barbara
Published: December 2024

Introduction

A growing number of families are using exclusive breastmilk expression to feed their newborns. They need accurate information and support from their providers.

Methods

The purpose of this integrative review was to explore the prevalence, characteristics, practices, and outcomes of families who fed exclusively expressed breastmilk to their infants. The electronic databases of CINAHL, Scopus, PubMed, Web of Science, and article reference lists for articles on expressing human milk for infants were searched. Results were filtered to glean published studies between 2012 and 2022, academic journals, human studies, and English language journals while excluding secondary reviews and expert opinions. Both authors screened records within Covidence systematic review management software. Selected studies were evaluated for quality of evidence using the Johns Hopkins Research Evidence Appraisal Tool.

Results

Twenty‐seven studies were included in this review. Most families who exclusively expressed originally planned to directly breastfeed their newborns and only began pumping after encountering problems. The most frequently recurring theme was that advice from health care personnel was inconsistent. Women described a knowledge deficit and received more help with exclusive expression from informal social media groups than their providers. Prevalence of exclusive breastmilk expression is highest in Asian countries and in the neonatal intensive care unit environment. These women had a shorter duration of human milk feeding and higher likelihood of cessation compared with women who both fed expressed milk and directly breastfed.

Discussion

Only recently have breastfeeding researchers begun distinguishing the type of milk (human milk or artificial formula) from the feeding method in their publications. This approach allows clinicians to provide better guidance on the outcomes of each feeding method. As clinicians, we can help families by encouraging them and providing consistently accurate information. Solely feeding expressed human milk is a valid option when the lactating person is unable or unwilling to directly breastfeed.
Does cross‐fertilization occur in recent macroeconomics? A quantitative exploration of the interactions between DSGE and MAB models
Authors: Baccini Alberto , Cioni Martina , Dal Pont Legrand Muriel , Petrovich Eugenio
Published: December 2024

The dominant approach to macroeconomics has always claimed its capacity to incorporate new ideas, continuously adapting its models in order to address contemporaneous challenges. This narrative leads to present academic macroeconomics research as driven by a continuous linear progress. 2008 and its trail of crises seems to have revealed more openly that such interactions, to consider that they may have existed, may no longer operate. Focusing on recent period, we propose to challenge this narrative, investigating whether such interactions still exist today and questioning their nature. We established a set of 2299 articles composed by Dynamic Stochastic General Equilibrium (DSGE) models and Macro Agent‐Based Models (MABM). We investigate the structure of the social communities authoring these articles and their intellectual interactions in view of establishing their relative fragmentation or strong scientific unity. Bibliographic coupling reveals that DSGE and MABM literatures refer to two different sets of bibliographic references. We also pay attention to two communities known to be interstitial: HANKs and hybrid models. While the overall results exhibit a relative fragmentation of these communities, they do not provide evidence of collaboration between MABM and DSGE authors. Rather, results suggest a completely dissymmetric influence from DSGE on the MABM literature
Exact likelihood for inverse gamma stochastic volatility models
Authors: Leon‐Gonzalez Roberto , Majoni Blessings
Published: December 2024

We obtain a novel analytic expression of the likelihood for a stationary inverse gamma stochastic volatility (SV) model. This allows us to obtain the maximum likelihood estimator for this nonlinear non‐Gaussian state space model. Further, we obtain both the filtering and smoothing distributions for the inverse volatilities as mixtures of gammas, and therefore, we can provide the smoothed estimates of the volatility. We show that by integrating out the volatilities the model that we obtain has the resemblance of a GARCH in the sense that the formulas are similar, which simplifies computations significantly. The model allows for fat tails in the observed data. We provide empirical applications using exchange rates data for seven currencies and quarterly inflation data for four countries. We find that the empirical fit of our proposed model is overall better than alternative models for four countries currency data and for two countries inflation data.
Amyloid‐beta pathology in a case with dementia with Lewy bodies with a rapidly progressive clinical course similar to Creutzfeldt–Jacob disease
Authors: Fujii Shintaro , Takahashi‐Iwata Ikuko , Oshima Yuki , Horiuchi Kazuhiro , Tanei Zenichi , Satoh Katsuya , Kitamoto Tetsuyuki , Tanaka Shinya , Yabe Ichiro
Published: December 2024

Most cases of dementia with Lewy bodies (DLB) follow a chronic course. However, some cases of rapidly progressive dementia (RPD) are difficult to distinguish from other diseases. Herein, we report how to differentiate DLB presenting with RPD from other diseases and its pathological features, with examples from our own experience. A 70‐year‐old man with RPD and psychiatric symptoms, including hallucinations and delusions, was transferred to our hospital. We suspected Creutzfeldt–Jakob disease (CJD), but disease‐specific tests were all negative. The patient was treated with corticosteroids on the suspicion of an autoimmune condition; however, his symptoms did not improve. Based on the results of nuclear medicine and other tests, we suspected DLB and administered anti‐Parkinsonian drugs; however, they were ineffective, and the patient died. Brain autopsy revealed extensive deposits of Lewy bodies, which were pathologically diagnosed as DLB. Additionally, extensive deposition of senile plaques was observed; however, neurofibrillary tangles (NFTs) were not prominent. DLB generally presents as a chronic disease. However, some patients with DLB present with RPD; therefore, the differential diagnosis of other diseases, such as CJD, is very important. In addition, although this case was not diagnosed with Alzheimer's disease (AD) due to the lack of NFTs, extensive amyloid deposition was observed in the brain tissue. Previous reports have described cases of RPD with amyloid deposition alone, and in this case too, it is suggested that amyloid deposition might have had a strong influence on the clinical course of RPD.
Navigating Treatment‐Induced Head and Neck Malignancies in Cancer Survivors
Authors: Girardi Fábio Muradás , Pesenatto Gustavo Guthmann , Fuchs Larissa Dill , Maahs Thomas Peter , Treister Nathaniel S. , Maahs Gerson Schulz
Published: December 2024

Cancer presents a significant global health burden. Traditional treatment modalities, especially radiotherapy and chemotherapy, have improved survival, but they have long‐term consequences. Treatment‐induced malignancies, a growing concern, pose risks to survivors. Often with limited treatment options, these tumors tend to have a worse survival rate. A thorough understanding of the main risk groups is critical for lifelong follow‐up and personalized care strategies. This review provides an update on the knowledge of treatment‐induced malignancies of the head and neck in cancer survivors; specifically, it discusses the risks, histological considerations, diagnosis and treatment strategies, follow‐up recommendations, and future perspectives.
Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer
Authors: Kopecka Katerina , Herman Michal , Michalek Jaroslav , Zapletalova Jana , Hermanova Marketa , Liptakova Priska , Hendrych Michal , Mozola Michal , Pink Richard
Published: December 2024

Objectives

Tumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.

Materials and Methods

The study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan–Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.

Results

Significant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease‐free survival. High tumor budding was identified as an independent prognostic factor for disease‐specific and overall survival.

Conclusions

The ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.
Intrinsic Capacity and Instrumental Activity of Daily Living Among Community Dwelling Elderly in China: The Mediating Effect of Two‐Way Social Support and Sense of Coherence
Authors: Hu Qingqing , Xu Jiajia , Ren Yifei , Ding Jie , Chu Ting
Published: December 2024

Objectives

To explore the influence of intrinsic capacity (IC) on instrumental activities of daily living (IADL) among community‐dwelling elderly and to analyze the chain‐mediated effects of two‐way social support, and sense of coherence (SOC).

Design

This study was a cross‐sectional research design. Participants were recruited from September 2023 to December 2023 from Hangzhou City, Zhejiang Province, China, using a multistage sampling method.

Sample

Participants in this study were at least 60 years old and had been currently living in the community for at least 1 year (n = 458).

Measurements

The Integrated Care for Older People screening tool, the Brief Two‐Way Social Support Scale, the Sense of Coherence Scale‐13, and the Functional Activities Questionnaire were used to collect relevant data, which were statistically tested using structural equation modeling and multiple mediation effects.

Results

There were correlations between IC, two‐way social support, SOC and IADL in community‐dwelling elderly (all p < 0.01). IC predicted two‐way social support (β = 0.570, p < 0.001), SOC (β = 0.544, p < 0.001) and IADL (β = −0.492, p < 0.001); two‐way social support had a positive predictive effect on SOC (β = 0.363, p < 0.001) but a negative predictive effect on IADL (β = −0.193, p < 0.001); SOC negatively predicted IADL (β = −0.150, p < 0.05).

Conclusions

To mitigate the impact of declining IC on IADL among community‐dwelling elderly, to sustain independent living, and to reduce the risk of progression to illness and disability, this study proposes two‐way social support and SOC as potential effective intervention targets. This conclusion holds implications for the assessment and intervention of elderly health, as well as the formulation of public health policies.
Glycomolecules: from “sweet immunity” to “sweet biostimulation”?
Authors: Boulogne I. , Mirande‐Ney C. , Bernard S. , Bardor M. , Mollet J.‐C. , Lerouge P. , Driouich A.
Published: December 2024

Climate changes and environmental contaminants are daunting challenges that require an urgent change from current agricultural practices to sustainable agriculture. Biostimulants are natural solutions that adhere to the principles of organic farming and are believed to have low impacts on the environment and human health. Further, they may contribute to reducing the use of chemical inputs while maintaining productivity in adverse environments. Biostimulants are generally defined as formulated substances and microorganisms showing benefits for plant growth, yield, rhizosphere function, nutrient‐use efficiency, quality of harvested products, or abiotic stress tolerance. These biosolutions are categorized in different subclasses. Several of them are enriched in glycomolecules and their oligomers. However, very few studies have considered them as active molecules in biostimulation and as a subclass on their own. Herein, we describe the structure and the functions of complex polysaccharides, glycoproteins, and glycolipids in relation to plant defense or biostimulation. We also discuss the parallels between sugar‐enhanced plant defense and biostimulation with glycomolecules and introduce the concept of sweet biostimulation or glycostimulation.
Exploring the mechanisms underlying recovery from freeze–thaw injury in Colobanthus quitensis: mechanistic insights via transcriptome profiling
Authors: Min Kyungwon , Sulaiman Syahril , Jeong Jihye , Lee Hyodong , Lee Jungeun , Lee Jun Hyuck , Lee Hyoungseok
Published: December 2024

Antarctic plants face significant challenges due to exposure to freeze–thaw stress throughout their life cycle. The ability to recover from freeze–thaw injuries during post‐thaw recovery (PTR) periods is a crucial skill for their survival and growth. However, no research, to the best our knowledge, has explored their recovery mechanisms at the cellular and molecular levels. To investigate the potential cellular mechanism during PTR periods, we focused on Colobanthus quitensis, one of solely two vascular plant species in the Antarctic Peninsula. Having determined the lethal temperature causing 50% cellular injury (LT50) under freezing to be −8.0°C, we subjected plants to sub‐injurious (−7.0°C) and injurious (−9.0°C) freezing treatments. We then compared recovery abilities at these stress levels using physiological indicators such as ion‐leakage, PSII quantum efficiency (Fv/Fm), and antioxidant enzyme activities. Comparative analysis indicated that plants exposed to −7.0°C progressively recovered during PTR periods, showing reduced ion‐leakage and increased Fv/Fm, while those stressed at −9.0°C exhibited irrecoverable damage with lower antioxidant enzymes activities. To investigate the molecular basis of recovery, we examined transcriptome changes in tissues exposed to −7.0°C during PTR periods through GO and KEGG pathway enrichment analyses. These analyses identified six potential cellular events involved in the recovery process, including ionic & pH homeostasis, cell wall remodeling, protein repair, defense against potential microbial attacks, free radical scavenging, and DNA repair. Understanding the cellular and molecular mechanisms of recovery from freeze–thaw injuries enhances our knowledge on how Antarctic plants adapt to extreme environments, offering valuable insights into their survival strategies.
Facilitating Individual Innovation from the Perspective of Social Network Ties: A Fuzzy‐Set QCA Approach
Authors: Liu Tao , Lu Shaokai , Mao Yanhui
Published: December 2024

Pursuing successful innovation poses a significant challenge for employees, as generating creative ideas does not guarantee final innovation outcomes (i.e., products). To enrich our understanding of the critical factors that contribute to the success of transforming creative ideas into innovation outcomes, drawing on the social network perspective and configuration theory, we utilize the fuzzy‐set qualitative comparative analysis (fsQCA) approach to identify how different social network tie configurations facilitate various stages of individual innovation, including idea generation and idea implementation. Through a survey of 216 R&D employees in China, we have identified four pathways with distinct configurations that promote high levels of idea generation and three pathways that facilitate high levels of idea implementation. This work contributes to developing a configurational strategy for facilitating individual innovation from the perspective of social network ties, thus shedding light on how employees might successfully traverse different stages of the innovation journey.
Patè olive cake and its solid extract as amendments for ryegrass (Lolium perenne L.): Effects on soil chemical, microbiological and enzymatic characteristics and on plant yield and N content
Authors: Neri Ulderico , Fontana Claudia , Corti Giuseppe , Socciarelli Silvia , Migliore Melania , Aromolo Rita , Benedetti Anna , Salvati Ascenzo , Bellincampi Daniela , Sciubba Fabio , Pontiggia Daniela , Beni Claudio
Published: December 2024

A peculiar solid olive mill waste called Patè Olive Cake (POC), produced by decanters of latest generation, and its derivative solid extract from centrifugation called ‘pellet’ were evaluated as soil amendments on a pot cultivation of ryegrass in sub‐acid and sub‐alkaline soils. Characterization of POC and pellet was performed to determine their main chemical characteristics and phytochemical profile by conventional methods, NMR and HPLC to evaluate their suitability for agronomic applications. In both soils, POC and pellet were applied and contrasted to (i) half dose of POC and pellet added of mineral nitrogen (N) and phosphorous (P) to correct the C:N ratio and to balance the phyto‐nutritive formula, (ii) commercial mineral and organo‐mineral fertilizers and (iii) untreated soil (Control). During the ryegrass annual cycle, the vegetative responses and the N concentration were monitored in the epigeal biomass. At the end of the experiment, soil samples were taken from the pots to determine the main physicochemical characteristics and to carry out genomic and enzymatic investigations. Both soils treated with POC and pellet supplemented with N and P showed a significant increase in biomass productions compared to Control (+36.32%) and to commercial fertilizers (+14.34% and + 16.41%, respectively, to mineral and organo‐mineral fertilizers). In all treatments, higher cumulative biomass productions were observed in the sub‐acid soil (+7.02%). In both soils, abundance and structure of fungi and bacteria communities showed no difference compared with the Control. Furthermore, enzymatic analysis indicated that microbial activity was not adversely affected by POC and pellet treatments. Our results indicate that POC and pellet can be used as soil amendments, contributing to reduce the use of chemical fertilizers and implementing circular economy and sustainability.
CsCBF1/CsZHD9‐CsMADS27, a critical gene module controlling dormancy and bud break in tea plants
Authors: Hao Xinyuan , Tang Junwei , Chen Yao , Huang Chao , Zhang Weifu , Liu Ying , Yue Chuan , Wang Lu , Ding Changqing , Dai Wenhao , Yang Yajun , Horvath David P. , Wang Xinchao
Published: December 2024

Tea plants are perennial evergreen woody crops that originated in low latitudes but have spread to high latitudes. Bud dormancy is an important adaptation mechanism to low temperatures, and its timing is economically significant for tea production. However, the core molecular networks regulating dormancy and bud break in tea plants remain unclear. In the present study, a MADS‐box transcription factor CsMADS27 was identified in tea plants. Gene and phenotype characterizations following ectopic overexpression and endogenous silencing experiments are consistent with a role for CsMADS27 in dormancy and sprouting in different tea cultivars. Furthermore, CsDJC23 was found to be a downstream target of CsMADS27 and implicated in bud sprouting. Based on yeast one‐hybrid screening and comprehensive verification, CsCBF1 and CsZHD9 were identified as upstream transcriptional inhibitors and activators of CsMADS27, respectively, with the two proteins showing direct interactions and competitive binding effects. Histone acetylation (H3K27Ac) in the first exon and intron regions of CsMADS27 was associated with a positive role in CsMADS27 expression. These results revealed that CsMADS27 is a key transcription factor involved in the regulation of dormancy and bud break. Furthermore, the CsCBF1/CsZHD9‐CsMADS27 module plays a critical role in sensing environmental factors and accurately regulating the growth and development of overwintering buds in tea plants.