bluuebunny/crossref_metadata_2025 huggingface dataset:
ARTE RUPESTRE EN LLAPLLAQ’ATA – TAMBOBAMBA: Y SU CONFIGURACIÓN GEOGRÁFICA
Authors: Arroyo Abarca Patricia M.
Published: July 2021

En este artículo presentamos una hipótesis sobre el arte rupestre y la forma en que hay que entenderla, para luego introducirme en el proceso de domesticación y pastoreo de camélidos en nuestra área de estudio, basado los enfoques de la arqueología simbólica y estructuralista así como la del paisaje, de tal forma que podamos asimilar el significado de la cultura material y los conflictos en la identificación de especies de camélidos en el arte rupestre, los colores utilizados y la reutilización de este espacio, en una época determinada y sobre la interrogante del por qué, prefirieron estos espacios para colocar a sus difuntos y contextualizarnos con el espacio inmediato en la que se desarrolló esta sociedad de pastores de camélidos de altura.
DIAGNÓSTICO Y CAMBIOS ESPACIALES EN EL PARQUE ARQUEOLOGICO DE OLLANTAYTAMBO
Authors: Bolívar Yapura Wilber
Published: July 2021

El presente trabajo se realiza desde la perspectiva de la Gestión del Patrimonio Cultural y sobre la base de los trastornos y cambios espaciales, que se identificaron en el ámbito del Parque Arqueológico de Ollantaytambo, (PAO) teniendo como base la información ofrecida en la literatura del sitio, el proceso de elaboración del Plan Maestro del PAO del año 2005 hoy desactualizado y lamentablemente no implementado, además de experiencias propias, ofreciendo un diagnostico situacional de los asentamientos humanos a través de ejes, como un documento de integración y adecuación metodológica.
LA CHAKANA Y LA CRUZ CRISTIANA: RITUALES, RELIGIÓN, FIESTAS, IDEOLOGÍAS Y SIMBOLOGÍAS EN LOS CONJUNTOS DE SIKURIS URBANOS
Authors: Sánchez Huaringa Carlos Daniel
Published: July 2021

La Fiesta de las Cruces tiene una importancia inusitada en el altiplano y este mismo ha sido recreado por los conjuntos urbanos de sikuris en Lima desde la década de los 80 en adelante. Se trata de una de las fiestas religiosas más esperadas por este movimiento urbano que se caracteriza por sus discursos ideológicos de izquierda marxista conjugados con utopía andina. Estos portan como elemento central de la fiesta y de veneración a la cruz cristiana y la cruz andina llamada chakana.
Investigación arqueológica en un asentamiento rural del Valle de Ayacucho, Perú
Authors: Valdez Lidio M. , Valdez Cárdenas Julio Ernesto
Published: July 2021

La manera como el centro urbano de Huari del valle de Ayacucho llegó a establecerse es un tema de mucho interés. Sin embargo, el tema sigue siendo poco discutido. Teniendo en consideración información arqueológica recuperada de un asentamiento rural que existió en lo que vino a constituir la periferia de Huari, aquí discutimos el proceso social que parece haberse dado en el valle de Ayacucho entre el final del Periodo Intermedio Temprano e inicios del Horizonte Medio. La evidencia en consideración sugiere el abandono de muchos poblados rurales a finales del Periodo Intermedio Temprano, cuando sus habitantes parecen haber buscado refugio en centros que ofrecieron mayor protección. Todo esto parece haber ocurrido en medio de la violencia que empezó a incrementarse. De este modo, los asentamientos huarpa, viables por generaciones, se vieron obligados a quedar desocupados cuando sus habitantes llegaron a concentrarse en centros específicos como Huari.
Las chullpas soterradas de Yarcoq y la presencia de pastores de puna wari en la Cordillera Negra, Ancash
Authors: Olvera Juan Paredes
Published: July 2021

En el presente estudio se muestran los resultados de excavación en el sitio arqueológico de Yarcoq, ubicado en el flanco oriental de la Cordillera Negra en el departamento de Ancash. El sitio constituye un cementerio compuesta por 18 estructuras funerarias, de las cuales 14 se vinculan a la época wari y las otras 4 a la época recuay. Se evidencia dos tipos de arquitectura funeraria, las tumbas subterráneas y las chullpas, cada una con sus características particulares y grado de sofisticación, los cuales se encontraban en función a los recursos que cada grupo tuvo acceso para construir estos monumentos. Estos grupos habrían participado en una dinámica constante de intercambio de productos entre la sierra y la costa por lo que políticamente conformarían una unidad.
Los dominicos y los pueblos indígenas de Madre de Dios
Authors: Dávila Francia Jesús Taylor
Published: July 2021

El presente trabajo de gabinete se inicia en a los últimos años del 90 del siglo pasado y que consistió en identificar la llegada de los evangelizadores a los pueblos de los amarakaeris. En un inicio el diario “El Comercio” fue el primer instrumento de búsqueda, después tuvimos contacto con la colección de La Revista Dominicana, la revista de la Sociedad Geográfica de Lima y posteriormente abrir otras posibilidades. El papel jugado por la congregación dominica no está lejana al proceso de evangelización y colonización de las diferentes partes de América y parte del mundo por otras sectas. La extirpación de idolatrías fue el principal instrumento aplicado a pesar que la prensa pasada y actual traten de hacer ver a los padres dominicanos como los salvadores de personas sin almas de los indígenas, y que como salvadores llegaron los supuestos héroes vestidos de sotanas. La otra forma de violencia fue más abierta y miserable: el período del caucho, con Fitzcarrald a la cabeza. Sea una u otra se enfrentaron en desventaja dos cosmovisiones diferentes. Está probado que las fantasías, los mitos y leyendas tienen su origen en un contexto y realidad determinada y que en los pueblos de Madre de Dios no había antes de la llegada de los evangelizadores y colonizadores la idea de santo, vírgenes, ni de arcángel u otros que se parezcan. Estas no formaban parte de la cosmovisión de nuestros pueblos amazónicos, en general. Este proceso llevado a cabo entre los grupos indígenas de la región aludida formó parte de un plan mundial de evangelización y colonización.
Propuesta de un Índice de Bofedal para la Teledetección de Bofedales en Cabeceras de Cuenca Usando Datos Imágenes de los Sensores TM, OLI a bordo de los Satélites Landsat - Caso Estudio: Bofedal Chunal, Cuenca Alta del río Chillón
Authors: García Jorge , Guerrero Jhon , Willems Bram , Espinoza Raul
Published: July 2021

Esta investigación propone un Índice de Bofedal (IB) para identificar los bofedales, ubicados sobre los 3800 ms.n.m. La propuesta del IB es un resumen de la tesis de maestría de Garcia Dulanto, (2018) y se fundamenta en dos métodos: el primero basado en la clasicación Linear Spectral Unmixing queemplea firmas espectrales seleccionadas de elementos característicos del área de estudio. Se seleccionó firmas espectralmente ideales (endmember, EM) para representar a : bofedales (EM bofedal), rocas (EM roca) y suelo desnudo (EM suelo). El segundo método está basado en los índices o parámetrosbiofísicos NDVI, NDWI y NDII. La combinación en imagen RGB: NDII, NDVI, NDWI muestra los bofedales en el área de estudio en tonos amarillos. Se integran los dos métodos usando la correlación de Pearson entre la fracción del endmember-bofedal y de los bofedales. Se obtiene máxima y mínima correlación con los índices NDWI y NDII. Con estos índices se propone un índice IB = (NDWI - NDII)/(NDWI + NDII) para zonicar de manera directa los bofedales. El IB fue validado mediante las imágenes de alta resolución de Google Earth, obteniendo un acierto de 98.36 %.
Uterine Didelphys with Transverse Vaginal Septum – A Complex rare Müllerian anomaly
Authors: Khan Dina Aisha , Sharma Nalini , Saha Anusmita , Das Rituparna , Panda Subrat
Published: July 2021

During the development of the female genital tract, any insult to the normal development process results in a set of intriguing abnormalities known as Müllerian duct abnormalities. The uterine didelphys is the second least common type of anomaly among these, which may commonly be associated with a longitudinal vaginal septum (lateral fusion defect). However uterine didelphys along with a transverse vaginal septum (lateral fusion plus resorption defect) is a very rare finding and to the best of our knowledge, thecase that we hereby report is the second one in literature.A 16-year-old unmarried girl presented with primary amenorrhoea and cyclical pain for 18months.On clinical examination and imaging, a case of uterine didelphys and transverse vaginal septum was found. Her urinary tract was normalon USG and MRI evaluation. Excision of the septum was done by abdomino-vaginal approach. The patient was discharged well.We conclude that a patient presenting with primary amenorrhea especially with cyclical dysmenorrhea with a transverse vaginal septum on examination should be thoroughly investigated for associated upper genital tract abnormalities as the treatment strategy and prognosis is largely dependent on the correct classification of the anomaly.
On the Edge of Meaning: the Thingness of Artwork
Authors: Sverdiolas Arūnas
Published: July 2021

Semiotics and philosophy both claim the status of a meta-language, hence enter into a dialogue with one another and each tries to translate the other into its own language. Contemporary analysis of material culture is informed by the so-called linguistic turn, which was performed by structuralism and affected all humanities. Ferdinand de Saussure’s semiology and the semiotics of Algirdas Julien Greimas and his colleagues work in this area by extrapolating the notion of the text to various fields of inquiry. The problematics of archeology, architecture, and other artifacts demand thinking through the issue of the matter. The paper provides proof that, in its attempts to respond to this demand, semiotics either stays within the frame of the idealistic semiotic existence of an indeterminate status or deploys metaphysical rudiments-and-supplements.
Approaches to optimizing the procedures of regulatory impact analysis: world experience and realities of Ukraine
Authors:   State Institution ", Nikiforuk Olena ,   Institute for Economics and Forecasting, NAS of Ukraine", Liashenko Ol'ha ,   State Institution "Institute for Economics and Forecasting, NAS of Ukraine"
Published: July 2021

The article investigates the experience of optimizing the institution of RIA in developed OECD countries and the European Commission, which allows to distinguish two main approaches to regulatory impact assessment, namely, using the full (classical) or simplified RIA models. The authors give particular attention to the principle of proportionality introduced in developed countries, whose essence is that the depth of analysis and evaluations should be proportional to the degree of the regulatory act's impact on economy, on individual stakeholders, and on public interests. Considered the importance of selecting "economically significant" regulatory acts. The authors carry out an analysis of the introduction of specific filters for the selection of regulatory acts for RIA in developed countries, namely: 1) definition of types of regulatory acts or spheres of regulation, which are subject to RIA; 2) classification and selection of acts according to the degree of significance; 3) and the existence of exceptions in the field of RIA in accordance with current legislation. To establish the second filter, namely to select regulatory acts based on their importance, the authors propose to use, in Ukraine, first, the introduction of the principle of proportionality, which will introduce into the practice of the assessment of regulatory acts the simplified and complete RIA models; secondly, to introduce combined (quantitative and qualitative) criteria for assessing the significance of draft regulatory acts with determining possible economic consequences of their adoption and in compliance with the criteria of priority of public interests (support for economic growth by optimizing costs and corresponding increase in value added, in the state and local budgets and others); and third, a step-by-step algorithm for implementing the world's best RIA practices into the practice of state regulation in Ukraine.
Twelve-Month Outcomes of the First 1000 Days Program on Infant Weight Status
Authors: Taveras Elsie M. , Perkins Meghan E. , Boudreau Alexy Arauz , Blake-Lamb Tiffany , Matathia Sarah , Kotelchuck Milton , Luo Mandy , Price Sarah N. , Roche Brianna , Cheng Erika R.
Published: July 2021

OBJECTIVES

To examine the effects of the First 1000 Days intervention on the prevalence of infant overweight and maternal postpartum weight retention and care.

METHODS

Using a quasi-experimental design, we evaluated the effects of the First 1000 Days program among 995 term, low-income infants and their mothers receiving care in 2 intervention community health centers and 650 dyads in 2 comparison health centers. The program includes staff training, growth tracking, health and behavioral screening, patient navigation, text messaging, educational materials, and health coaching. Comparison centers implemented usual care. Infant outcomes were assessed at 6 and 12 months, including weight-for-length z score and overweight (weight for length ≥97.7th percentile). We also examined maternal weight retention and receipt of care 6 weeks’ post partum.

RESULTS

The mean birth weight was 3.34 kg (SD 0.45); 57% of infants were Hispanic; 66% were publicly insured. At 6 months, infants had lower weight-for-length z scores (β: −.27; 95% confidence interval [CI]: −.39 to −.15) and lower odds of overweight (adjusted odds ratio [OR]: 0.46; 95% CI: 0.28 to 0.76) than infants in comparison sites; differences persisted at 12 months (z score β: −.18; 95% CI: −.30 to −.07; adjusted OR for overweight: 0.60; 95% CI: 0.39 to 0.92). Mothers in the intervention sites had modestly lower, but nonsignificant, weight retention at 6 weeks’ post partum (β: −.51 kg; 95% CI: −1.15 to .13) and had higher odds (adjusted OR: 1.50; 95% CI: 1.16 to 1.94) of completing their postpartum visit compared with mothers in the comparison sites.

CONCLUSIONS

An early-life systems-change intervention combined with coaching was associated with improved infant weight status and maternal postpartum care.
O eco das eleições 2018 no ciberespaço
Authors: Soares Diulia
Published: July 2021

Tem sido notável o crescimento de movimentos sociais como o Feminismo. Retirando-se perspectivas conservadoras sobre ele, é inegável sua necessidade, legitimidade e importância, assim como seus avanços e conquistas. As mudanças pelas quais estamos passando devido à inserção intensiva da internet no nosso cotidiano estão se refletindo também nas maneiras de luta, de debate e de expressão. Nesse sentido, é notável também o crescente número de mulheres engajadas, organizadas por seus direitos e como isso potencializa a força política dessas organizações. Manuel Castells (2012) afirma que a relação intrínseca entre ações sociopolíticas que se iniciam nas redes sociais e impactam multidões coesas e politicamente engajadas estão causando essas enormes mudanças nos rumos político-institucionais. É a partir dessa perspectiva que se pretende compreender a articulação ocorrida nas Eleições 2018 no Brasil. Nesse sentido, olharemos para a movimentação realizada pelas mulheres, conhecida como “Ele Não”, e para as articulações realizadas por apoiadores do, então candidato, Jair Bolsonaro.
OS SERTÕES ONSCREEN IN PAULO GIL SOARES’S O HOMEM DE COURO (1969/70)
Authors: Broadus Victoria
Published: July 2021

This article examines filmmaker Paulo Gil Soares’s early work with a particular focus on the documentary O Homem de Couro (1969/70), in the context of Brazil’s military dictatorship (1964-85), the documentary-film initiative known as the “Farkas Caravan,” and 1960s-era Brazilian documentary more broadly. I argue that Soares’s O Homem de Couro represents an audiovisual renewal and revision of Euclides da Cunha’s portrayal of the northeastern vaqueiro in Os Sertões (1902). In the film, Soares’s depiction of the vaqueiro served as both a tribute to these national folk heroes and a reminder to viewers that da Cunha’s scathing turn-of-the-century portrait of the northeastern social order should not be considered a relic of the past. Timeless northeastern verses drive the narrative, reinforcing that message. In this way, Soares made a film that was both beautiful and denunciatory without resorting to pedagogical voiceovers or orthodox dogma. He meanwhile updated key elements of Os Sertões for the 1960s and ‘70s. Soares offered subjectivity that was lacking in da Cunha’s account, discrediting da Cunha’s nineteenth-century biological and geographical determinism. He also documented inauspicious shifts in this labor market that threatened the vaqueiro’s future. In the early 1970s, Soares would go on to found the influential documentary-journalism program Globo Repórter. By focusing on his work with the Farkas Caravan, this article contributes a new perspective on a key but previously overlooked element in the formation of the Brazilian school of documentary film and journalism, and on the enduring legacies of da Cunha’s work.
A legitimação de Costa e Silva nas páginas da revista Realidade (1966-1967)
Authors: Migotto Filho Jonas
Published: July 2021

Este artigo tem como objetivo analisar o perfil “Feliz Aniversário Seu Artur”, publicado na revista Realidade de maio de 1966. A reportagem sobre Artur da Costa e Silva, ministro da Guerra na época de publicação, prenuncia sua chegada ao cargo de líder do governo ditatorial no Brasil. Realidade era uma revista considerada transgressora quando abordava o plano dos costumes, entretanto, mantinha diálogo com setores conservadores, como nos perfis dos ditadores, constantemente publicados durante os primeiros anos do periódico, sempre escritos por Luiz Fernando Mercadante. Dessa forma, pretende-se compreender, por meio de uma análise crítica da narrativa, as estratégias utilizadas para construir o personagem, que foi retratado, posteriormente, em mais três oportunidades, direta ou indiretamente, evidenciando uma negociação simbólica entre a revista e a Ditadura Civil-Militar. Por isso, busca-se, também, compreender os modos de operação da ideologia na versão final que chegava aos leitores. Além disso, discute-se a possibilidade de utilização das revistas não só como fontes, mas como objetos em si na pesquisa histórica, capazes de desvelar os jogos de poder de uma época. Por fim, percebe-se que o perfil evidencia as relações de poder entre a Realidade e a Ditadura, pelas escolhas presentes no texto e pelo cuidado em reconstruir Costa e Silva em outras ocasiões, legitimando o perfilado ao público leitor.
análise sobre a relação entre as condições de trabalho e a saúde de professores estaduais em Educação Física de Pelotas – RS
Authors: Oliveira Ivan Bremm de , Silveira Leonardo Lemos , Frizzo Giovanni Felipe Ernst
Published: July 2021

O artigo objetiva analisar a relação entre as condições de trabalho e saúde dos professores de Educação Física que atuam no Ensino Médio da Rede Estadual de Ensino de Pelotas no Rio Grande do Sul, na cidade de Pelotas. Como instrumento metodológico, utilizamos um questionário com perguntas abertas e fechadas intitulado Enquete Docente. Participaram 26 professores de 18 escolas urbanas e rurais que atuam no Ensino Médio Politécnico. Os dados foram analisados através da análise estatística descritiva e de conteúdo. Os resultados apontaram a influência negativa da intensificação e precarização do trabalho docente na qualidade de vida e do trabalho em três aspectos centrais: a) condições de infraestrutura: falta de recursos materiais e equipamentos; b) condições de trabalho: jornada exaustiva, multiempregos, desvalorização salarial; e, c) saúde física e mental: desmotivação, desgaste, estresse. Aproximadamente metade deles já utilizou medicamentos em razão decorrente do trabalho. As condições estruturais, o regime de trabalho, a baixa remuneração e a insatisfação com o atual plano de carreira, são aspectos que interferem negativamente nas condições objetivas de suas vidas e ocasiona o adoecimento.
Palavras-chave: Educação física; saúde docente; condições de trabalho.
Insetos como bioindicador de qualidade ambiental em ambientes aquáticos
Authors: De Oliveira Santos João Paulo , Novais Lopes Gleidyane , Santos Gonzaga Kennedy , Gomes Abreu Khyson , Souza Muniz Luiz Eduardo , De Almeida Cartaxo Paulo Henrique
Published: July 2021

Estratégias de monitoramento da qualidade ambiental dos mais diversos ecossistemas vêm sendo desenvolvidos, principalmente para os ambientes aquáticos, espaços severamente atingidos pelas ações antrópicas. Dentre as técnicas desenvolvidas, destaca-se o uso de espécies bioindicadoras, organismos que apresentam sensibilidade a mudanças no meio e respondem a esses estímulos antropogênicos. Nesse sentido, o presente estudo objetivou analisar na literatura científica os avanços no uso desses organismos, com ênfase para a classe Insecta e sua aplicabilidade de utilização para o monitoramento da saúde ecológica de ecossistemas aquáticos. As principais ordens de insetos reportadas para utilização em bioindicação da qualidade ambiental de corpos hídricos são Diptera e Odonata. Chironomidae (Diptera) é frequentemente aplicada em estudos de contaminação de metais pesados, sendo analisado o desenvolvimento de suas larvas para fins de bioindicação, as quais se desenvolvem em contato com o sedimento, importante compartimento de acumulação de contaminantes no corpo aquático. Insetos da ordem Odonata podem ser utilizados na fase larval ou adulta para bioindicação cujas famílias podem responder às mudanças no meio, sendo algumas mais sensíveis que outras a mudanças ambientais. A utilização desses organismos pode representar uma estratégia eficiente no monitoramento desses ambientes, facilitando a interpretação dos efeitos dos impactos antrópicos sobre esses ecossistemas e em suas relações ecológicas.
Palavras-chave: Recursos hídricos; monitoramento ambiental; Odonata; Diptera.
Buddhist Violence and Religious Authority
Authors: Kitts Margo , Juergensmeyer Mark
Published: July 2021

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Dharma and its Discontents
Authors: Thompson John
Published: July 2021

This article critically re-examines the “received wisdom” on Buddhism— its history, traditional lore, monastic institutions, and ritual practices— acknowledging the fact of violence within Buddhism while striving for a nuanced understanding by looking at the life of Kumarajiva (ca. 344–413). A legendary figure in Sino-Japanese Buddhism, Kumarajiva has long been lauded as a wondrous exemplar of the Dharma at work, making accounts of his life valuable resources for understanding Buddhism in medieval China, including the place of violence. My intention is not to condemn Buddhism as a “violent religion” but to encourage us to consider just how pervasive and complex the role of “violence” seems to be within Buddhism (both in the past and in the present), and critically trace out some of its implications.
Exploring probability concepts in a game context
Authors: Sharma Sashi , Sharma Shweta , Doyle Phil , Marcelo Louis , Kumar Daniel
Published: July 2021

Learning about probability can pose difficulties for students at all levels. Performing probability experiments using games can encourage students to develop understandings of probability grounded in real events. In this reflective paper, we explore the thinking of a group of students and teachers as they reasoned about experimental and theoretical probabilities in a game context. We designed a probability lesson based on the game LuLu (McCoy et al., 2007). In this article we share the activity and describe the kinds of explorations that can be facilitated in any secondary school mathematics classroom. We were particularly interested in investigating whether students could construct a bi-directional link between experimental probability and theoretical probability. Overall, the lesson enabled students to gain hands-on experience in data collection and analysis and better comprehend affordances of culturally diverse games.
Interprofissionalismo na Estratégia Saúde da Família: um olhar sobre as ações de promoção de saúde bucal
Authors: Alves Hipácia Fayame Clares , Collares Patrícia Moreira Costa , Alves Renata de Sousa , Brasil Christina César Praça , Carnaúba Jéssica Pinheiro
Published: July 2021

Resumo O trabalho interprofissional é necessário para a consolidação do modelo de atenção à saúde, porém o cirurgião-dentista encontra muitos desafios para trabalhar em equipe. Este estudo objetivou conhecer o interprofissionalismo, no âmbito da saúde bucal, entre os trabalhadores graduados da Estratégia Saúde da Família. Tratou-se de um estudo exploratório e transversal, com abordagem qualitativa, desenvolvido com 39 profissionais graduados da Atenção Básica do município de Icó, Ceará, Brasil. Os sujeitos pesquisados declararam uma deficiência na manutenção técnica nas unidades, a recorrente falta de insumos e a demanda excessiva de usuários como elementos que prejudicam o trabalho em equipe, assim como a inexistência de um plano de cargos, carreiras e salários, sendo um motivo de descontentamento entre os profissionais. Todos consideraram importante o trabalho interprofissional e sugeriram reuniões periódicas, atividades compartilhadas mais frequentes e capacitações como forma de intensificar essa ação. Apesar de o trabalho interprofissional ser reconhecido como fundamental para as ações de cuidado, é necessário mais comprometimento e apoio da gestão.
Importance of access to epilepsy monitoring units during the COVID‐19 pandemic: consensus statement of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology∗
Authors: Beniczky Sándor , Husain Aatif , Ikeda Akio , Alabri Haifa , Cross J. Helen , Wilmshurst Jo , Seeck Margitta , Focke Niels , Braga Patricia , Wiebe Samuel , Schuele Stephan , Trinka Eugen
Published: July 2021

Restructuring of healthcare services during the COVID‐19 pandemic has led to lockdown of epilepsy monitoring units (EMUs) in many hospitals. The ad‐hoc taskforce of the International League Against Epilepsy (ILAE) and the International Federation of Clinical Neurophysiology (IFCN) highlights the detrimental effect of postponing video‐EEG monitoring of patients with epilepsy and other paroxysmal events. The taskforce calls for action for continued functioning of EMUs during emergency situations, such as the COVID‐19 pandemic. Long‐term video‐EEG monitoring is an essential diagnostic service. Access to video‐EEG monitoring of the patients in the EMUs must be given high priority. Patients should be screened for COVID‐19, before admission, according to the local regulations. Local policies for COVID‐19 infection control should be adhered to during the video‐EEG monitoring. In cases of differential diagnosis in which reduction of antiseizure medication is not required, home video‐EEG monitoring should be considered as an alternative in selected patients.
Management of a first unprovoked epileptic seizure in adolescence and adulthood
Authors: Catarina Franco Ana , Parreira Sara , Bentes Carla , Pimentel José
Published: July 2021

An epileptic seizure is one of the causes of so‐called “transient neurological events” (TNEs). The differential diagnosis of a TNE relies mainly on history and physical examination. Laboratory markers are less frequently useful. After diagnosing an epileptic seizure, a distinction must be made between an acute symptomatic and an unprovoked seizure, since they have different treatments and prognosis. History, physical examination and other examinations (laboratory and imaging) are paramount in this distinction. After the diagnosis of a first unprovoked seizure, an EEG should be requested which may aid in establishing the diagnosis, evaluating the recurrence risk or ascertaining the self‐limited nature of the seizure. 3T‐MRI with an epilepsy protocol can be considered when CT has not clarified the aetiology. The decision to treat should be discussed with the patient/relatives, taking into account the risk of recurrence, the clinical characteristics (aetiology, seizure type, age, job, epileptic seizure schedule, comorbidities and polymedication), probability of AED side effects, and stigmatization. Nowadays, the chosen regimen is usually monotherapy with a second‐generation AED that better suits the patient's characteristics, comorbidities and concurrent medication. Counselling should include first aid, precipitating factors, sport and physical exercise in order to avoid possible driving restrictions, the need for therapy compliance, and risk of recurrence and SUDEP.
In the pursuit of the epileptogenic zone – listen carefully and look deeply
Authors: Nascimento Fábio A. , Srinivasan Visish M. , Sheth Sameer A. , Gavvala Jay R.
Published: July 2021

We report a 30‐year‐old right‐handed man with a history of drug‐resistant, non‐lesional, childhood‐onset focal epilepsy featuring (i) focal unaware seizures with left upper extremity automatisms and tonic posturing preceded by an aura of a ringing/beeping noise, and (ii) nocturnal hyperkinetic seizures. Non‐invasive video‐EEG, MEG, and PET were unable to delineate the epileptogenic zone (EZ) warranting an invasive investigation with bilateral depth electrodes (SEEG). SEEG data localized the EZ to the right superior temporal sulcus (STS) and right superior temporal gyrus (STG), wherein the auditory cortex lies, with subsequent ictal spread to anterior topography including the operculo‐insular region. This hypothesis explained the patient's semiology consisting of focal aware seizures featuring auditory phenomena and nocturnal hyperkinetic seizures. Our multi‐disciplinary team elected to proceed with a resection of the posterior right STG guided by electrocorticography (ECoG). Prior to resection, ECoG identified seizures arising from the peri‐sylvian region, seemingly discordant to previous SEEG data. Following resection of the posterior right STG, ECoG continued to show seizures from contacts overlying the parietal operculum. It was not until the cortex was resected, at the depth of the right STS, that ECoG no longer showed epileptiform abnormalities. Pathology revealed focal cortical dysplasia type 1A.
Early vagus nerve stimulator implantation as a main predictor of positive outcome in pediatric patients with epileptic encephalopathy
Authors: Russo Angelo , Hyslop Ann , Gentile Valentina , Boni Antonella , Miller Ian , Chiarello Daniela , Pellino Giuditta , Zenesini Corrado , Martinoni Matteo , Lima Mario , Ragheb John , Cordelli Duccio Maria , Pini Antonella , Jayakar Prasanna , Duchowny Michael
Published: July 2021

Objective: We describe a multicenter experience with VNS implantation in pediatric patients with epileptic encephalopathy. Our goal was to assess VNS efficacy and identify potential predictors of favorable outcome.

Methods: This was a retrospective study. Inclusion criteria were: ≤18 years at the time of VNS implantation and at least one year of follow‐up. All patients were non‐candidates for excisional procedures. Favorable clinical outcome and effective VNS therapy were defined as seizure reduction >50%. Outcome data were reviewed at one, two, three and five years after VNS implantation. Fisher's exact test, Kaplan‐Meier and multiple logistic regression analysis were employed.

Results: Twenty‐seven patients met inclusion criteria. Responder rate (seizure frequency reduction ≥ 50%) at one‐year follow‐up was 25.9%, and 15.3% at last follow‐up visit. The only variable significantly predicting favorable outcome was time to VNS implantation, with the best outcome achieved when VNS implantation was performed within five years of seizure onset (overall response rate of 83.3% at one year of follow‐up and 100% at five years). In total, 63% of patients evidenced improved QOL at last follow‐up visit. Only one patient exited the study due to an adverse event at two years from implantation.

Significance: Early VNS implantation within five years of seizure onset was the only predictor of favorable clinical outcome in pediatric patients with epileptic encephalopathy. Improved QOL and a very low incidence of adverse events were observed.
Evaluation of candidate genes in a Chinese cohort of atypical Rolandic epilepsy
Authors: Hu Xiaoyue , Tang Jihong , Hua Ying , Wang Yanping , Huang Jing
Published: July 2021

Objective. We aimed to identify new candidate pathogenic genes for atypical Rolandic epilepsy.

Methods. We retrospectively evaluated the data from 24 Chinese patients with atypical Rolandic epilepsy who underwent whole‐exome sequencing. Data were analysed regarding the frequency of affected genes, previously reported disease‐related genes, and evaluation based on Kyoto Encyclopaedia of Genes and Genomes (KEGG).

Results. We identified a frameshift mutation in the reported gene PRRT2, which is classified as pathogenic according to American College of Medical Genetics and Genomics guidelines (ACMG). We also identified a novel missense mutation in the PRRT2 gene in a family with three affected patients. Several other candidate genes were found in at least two patients, some of which were associated with other epilepsies (ADGRV1, CACNA1A, CHD2, CLCN2, HECW2, KIF1A, NPRL3, RELN and TSC2), while others were mainly associated with neuropsychiatric disease (SHANK3 and AUTS2). The KEGG analysis of 81 candidate genes associated with atypical Rolandic epilepsy identified a significant association with the GABAergic synapse. Candidate genes involved in the GABAergic synapse pathway included NSF, CACNA1A, as well as others.

Significance. Our study indicates that PRRT2 mutations may be associated with atypical Rolandic epilepsy. Moreover, we identified a number of unreported candidate genes, including ADGRV1, CHD2, CACNA1A, NSF, NPRL3, KIF1A, GJB2 and HECW2, also associated with atypical Rolandic epilepsy.
Multimodal approach in the pre‐surgical evaluation of focal epilepsy surgery candidates: how far are we from a non‐invasive ESI‐based “sourcectomy”?
Authors: Nobile Giulia , Consales Alessandro , Tortora Domenico , Pacetti Mattia , Gianno Francesca , Arnaldi Dario , Morbelli Silvia , Mancardi Margherita , Sartori Ivana , Cossu Massimo , Nobili Lino , Cataldi Matteo
Published: July 2021

The management of drug‐resistant patients with focal epilepsy is often challenging. Surgery is recognised as a useful and effective treatment option. The identification of the epileptogenic zone relies on the integration of clinical, neurophysiological, and neuroimaging findings. The role of non‐invasive functional neuroimaging techniques has been reported to add diagnostic accuracy to first‐line evaluations, avoiding invasive presurgical examinations in selected cases. In this view, we report the case of a 16‐year‐old male suffering from drug‐resistant focal epilepsy with episodes rarely evolving to a bilateral tonic‐clonic seizure. Conventional 1.5T and 3T MRI were considered uninformative. Based on electro‐clinical data, focal cortical dysplasia was suspected. The epileptogenic zone was identified with the integration of further non‐invasive functional neuroimaging techniques ([18F]‐fluorodeoxyglucose positron emission tomography and arterial spin labelling), where electrical source imaging played the main role. All techniques pointed towards a cortical region, where a 7T brain MRI identified a signal alteration consistent with focal cortical dysplasia. A tailored resection of the lesion located in the inferior frontal sulcus was performed, guided by intraoperative electrocorticography (strip and depth electrodes). Postoperative seizure freedom was achieved. The histopathology confirmed the suspicion of focal cortical dysplasia type IIa. With this case report, we highlight the importance of a multimodal approach in the presurgical evaluation of candidates for epilepsy surgery, which, in selected cases, may allow invasive procedures, such as stereo‐EEG, to be avoided in the investigation of the epileptogenic zone. Moreover, we underline the pivotal role of EEG source imaging, especially when focal cortical dysplasia is suspected.
Jacqueline du Pré as 'The Cellist' (2020)
Authors: Whittaker Adam
Published: July 2021

Few musicians of the twentieth century are as recognisable as Jacqueline du Pré. Her dazzling and distinctive talent, said to have enraptured audiences the world over, was overcome by a tragic diagnosis of MS. This sense of tragedy was all the more heightened by Du Pré’s famed physicality on the stage, leading critics to use all manner of analogies in describing her playing as a physical (and even sexual) experience. Her status as a musical celebrity, further intensified as she became one half of a classical music power couple, has led to numerous dramatic retellings and reimaginings of her biography, played out in film and TV, and now on stage. The most recent example of this fascination with Du Pré is the ballet The Cellist, Cathy Marston’s new work for the Royal Ballet, premiered in February 2020 to much critical acclaim. Its score, composed by Philip Feeney, features a cello soloist and interweaved repertoire extracts that have become so associated with Du Pré. Along with the characters of Barenboim, Du Pré, and her family, her 1673 Stradivarius cello is given a starring role in the form of Marcelino Sambé, a new take that makes this a distinctive contribution to media representations of Du Pré. This article examines the interactions across this complex web of musical representations of musical personae engrained in the cultural consciousness. It considers acts of musical performance, the musical instrument as living companion, and the representation of classical musical culture of the 1960s and 1970s, drawing attention to key features of Du Pré’s narrative re-presented in a new artistic form.
Maxillofacial Radiology 191
Authors: Walters Jaco
Published: July 2021

A 9-year-old female presented with a history of a firm painless bony swelling at the left mandible. A pantomograph (Figure 1) revealed a large radiopaque mass in the mandibular body with impaction of the 36. What are the most distinguishing radiological features and what is your provisional diagnosis?
Simple electroporation for efficient CRISPR/Cas9 genome editing in murine zygotes v2
Authors: E. Tröder Simon , Zevnik Branko
Published: July 2021

Electroporation of zygotes represents a rapid alternative to the elaborate pronuclear injection procedure for CRISPR/Cas9-mediated genome editing in mice. However, current protocols for electroporation either require the investment in specialized electroporators or corrosive pre-treatment of zygotes which compromises embryo viability. Here, we describe an easily adaptable approach for the introduction of specific mutations in C57BL/6 mice by electroporation of intact zygotes using a common electroporator with synthetic CRISPR/Cas9 components and minimal technical requirement. This protocol works efficiently with zygotes from a variety of genetic backgrounds and is compatible with other CRISPR nucleases like Cas12a.
Reklama İçerden Bir Bakış
Authors: ÇAMDERELİ Mete
Published: July 2021

Reklam tarihiyle ilgili çalışmalara çok az rastlanıyor. Bu temel kaygıdan hareketle bu çalışmanın amacı, reklamın bir belge niteliğiyle dönem okumasına imkan verip vermeyeceğidir. Bunu anlayabilmek için reklam hakkında çeşitli yerlerde yazılmış yazılara değil de salt reklam amacıyla Türkiye’de çıkan gazete ve dergilere ve onların da sadece sunuş yazılarına odaklanmak tercih edildi. Çeyrek yüzyıla yayılan ve ilk sayıları erişilebilir durumdaki on reklam gazete ve dergisi inceleme nesnesi olarak seçildi. Çalışma, zamansal olarak 1948-1974 yıllarına karşılık gelen yirminci yüzyılın üçüncü çeyreğiyle sınırlanmış oldu.
Bu amaç, kapsam ve sınırlılık çerçevesinde, reklam gazetelerinin ilk sayılarında yer alan sunuş yazılarının okunması yoluyla dönemin reklama ilişkin söylemi betimlenmiş, aynı zamanda reklamın dönemsel yapı ve işleyişi ortaya çıkmış oldu.
Üniversite Öğrencilerinin Özçekim Davranışları: Yeni Medyanın Etkin Kullanıcıları Olarak İletişim Öğrencileri Üzerinde Bir Araştırma
Authors: ŞİMŞEK Ali , KIZILHAN Taner , ELCİYAR Kemal
Published: July 2021

Fotoğraf temelli sosyal ağların yaygınlığı son dönemde hızlı bir ivme kazanmış, mobil telefonların gelişen kamera özellikleri de bu olguyu artırmıştır. Bu araştırma, iletişim fakültesi öğrencilerinin özçekim davranışlarını bazı kişisel ve demografik değişkenler açısından karşılaştırmalı olarak incelemek amacıyla yapılmıştır. Genel tarama modelinde yürütülen araştırmanın evreni, mobil teknolojiler konusunda, başka alanlardaki akranlarına oranla, görece daha yetkin olduğu varsayılan iletişim fakülteleri öğrencilerinden oluşmuştur. Araştırma örnekleminde Türkiye’deki iki devlet ve iki vakıf üniversitesinin iletişim fakültelerinde öğrenim gören toplam 613 lisans öğrencisi yer almıştır. Veriler, Balakrishnan ve Griffiths (2018) tarafından geliştirilen ve çeşitli ülkelerdeki araştırmalarda yaygın biçimde kullanılan Likert türü Özçekim Saplantısı Davranış Ölçeği ile toplanmıştır. Verilerin çözümlenmesinde hem betimsel hem yordamsal istatistiksel tekniklerden yararlanılmıştır. Sonuçlar göstermektedir ki, öğrencilerin cinsiyeti ve üniversite türünün (devlet-vakıf) genel özçekim saplantı düzeyi üzerinde anlamlı bir etkisi yoktur. Buna karşılık, öğrencilerin öğrenim gördükleri üniversiteler, bölümler, dönemler ile kullandıkları mobil telefonların markası ve günlük mobil telefon kullanım süreleri açısından anlamlı farklılıklar bulunmuştur. Ayrıca, üniversite türü dışında, neredeyse tüm bağımsız değişkenler açısından özçekim saplantısının alt boyutları üzerinde anlamlı farklılıklar belirlenmiştir.
Casas, gérmenes y virus
Authors: Nóbile Carla , Puppo María Eugenia , Sader Andrea
Published: July 2021

La casa se enferma, la casa nos enferma, la casa cura, la casa nos cura. La hipótesis de la vivienda como lugar donde se curan trastornos médicos y sociales es el punto de partida del presente artículo. El objetivo planteado es analizar, a través de tres episodios, la modernidad incipiente de la segunda mitad del siglo XIX, la modernidad hegemónica de la primera mitad del siglo XX y la contemporaneidad, la relación entre vivienda y enfermedad. En el combate a las enfermedades la arquitectura ha encontrado una excusa para repensar y reformular los paradigmas vigentes del habitar, y a inicios del siglo XXI nuevamente se enfrenta a este desafío disciplinar en el marco de la pandemia por el COVID-19, que ha evidenciado el conflicto ya existente entre las necesidades contemporáneas y un paradigma habitacional deudor de la modernidad.
Análisis del teletrabajo en las agencias de viajes turísticas en la ciudad de Cartagena-Colombia
Authors: Morelos-Gómez José , Lora-Guzmán Harold Steve
Published: July 2021

El presente artículo de investigación evalúa la conveniencia del teletrabajo en las agencias de viajes en Cartagena, Colombia. El tipo de investigación abordada fue descriptivo-analítica y se diseñó una herramienta estructurada in situ, la cual fue aplicada a los gerentes y administradores de 26 agencias de viajes del sector turístico registradas formalmente en la Cámara de Comercio de Cartagena. Como resultado se identificó que el teletrabajo como alternativa laboral, representa un futuro prometedor, debido a que el 58% de las empresas están de acuerdo en implementar esta alternativa laboral, siendo conscientes de todas las contribuciones en el desempeño administrativo, incremento de la productividad, la motivación y la disposición de los colaboradores. Se concluye que el 96% de las agencias de viajes utilizan las TIC como una herramienta significativa para impulsar las ventas y solo el 4% no las utilizan, lo que facilita la adaptación del teletrabajo en el sector analizado.
Technology : Impact on the Youth and Society
Authors: Bhagat Ashwin D. , Sharma Yogesh Kumar
Published: July 2021

As we become increasingly immersed in the virtual world, where humans no longer control machines but vice versa, technology is taking a toll on our human capabilities of adaptability, humor, and the need for communication. While technology is an integral part of our lives, data breaches, a lack of innovation and efficiency, and overdependence on technology have all been identified in recent years. This article investigates the negative implications of technology in terms of data storage, identity, security, the future of our hyper-connected youth, and the repercussions of data breaches, including their causes and results, as well as the overall psychological impact on individuals and society.
Insights on Mycoremediation of Contaminated Soil with Kerosene
Authors: Dash Suman Sasmita , Gawai Jyotsna , Dewangan Rishi , Singh Sudhanshu
Published: July 2021

Bioremediation of hydrocarbon contaminated soil is inexpensive and involves complete mineralization of organic contaminants to simple organic compounds, carbon dioxide, water and other inorganic compounds by the action of biological agents, according to their metabolic capacities.
Impact of Technology on Traditional Teaching - Learning Measures in The Era of Covid-19 Pandemic
Authors: Raut Bhakti Narendra
Published: July 2021

The period of 21stcentury is frequently respected as the period of Innovations and Technology. Today, Technology plays a significant part in our life. It is conceivable as it were through technology that distances are no more hindrances and training can be brought to the understudy's doorstep. The effect of innovation can be felt in each conceivable field and one such field is education. Instruction in its overall sense is a structure of learning in which the information, abilities and propensities from a gathering of individuals are changed from one age to next through instructing, preparing and research. Today, like never before, the job of instructive innovation in educating is of incredible significance in light of the utilization of data and correspondence advancements (ICT). Instructive innovation is a coordinated cycle of applying present day innovation to improve the nature of education. It is an efficient method of conceptualizing the execution and assessment of the instructive cycle, for example learning and educating furthermore, help with the use of current instructive educating methods. This paper features the significance of IT in educational areas, the effect of IT on study hall education, points of interest, and the detriments of IT.
A Review of Methodology and techniques for analysis of diabetes Prediction
Authors: Raut Janhavi R , Banger Priyanka
Published: July 2021

In almost all nations, diabetes mellitus was among the most prevalent persistent diseases and continues to boom in numbers and significance, as economic growth and urbanisation contribute to evolving lifestyles marked by decreased physical hobby and weight issues.In this paper, based on different predictive analytics algorithms, we analysed different cases related to diabetes mellitus and concluded that a single approach is not appropriate for predictive analytics.