bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review
Authors: Oargă (Porumb) Diana Patricia , Cornea-Cipcigan Mihaiela , Cordea Mirela Irina
Published: April 2024

Rosa spp., commonly known as rosehips, are wild plants that have traditionally been employed as herbal remedies for the treatment of a wide range of disorders. Rosehip is a storehouse of vitamins, including A, B complex, C, and E. Among phytonutrients, vitamin C is found in the highest amount. As rosehips contain significant levels of vitamin C, they are perfect candidates for the development of skincare formulations that can be effectively used in the treatment of different skin disorders (i.e., scarring, anti-aging, hyperpigmentation, wrinkles, melasma, and atopic dermatitis). This research focuses on the vitamin C content of several Rosa sp. by their botanical and geographic origins, which according to research studies are in the following order: R. rugosa > R. montana > R. canina > R. dumalis, with lower levels in R. villosa and R. arvensis, respectively. Among rosehip species, R. canina is the most extensively studied species which also displays significant amounts of bioactive compounds, but also antioxidant, and antimicrobial activities (e.g., against Propionibacterium acnes, Staphylococcus aureus, S, epidermis, and S. haemolyticus). The investigation also highlights the use of rosehip extracts and oils to minimise the harmful effects of acne, which primarily affects teenagers in terms of their physical appearance (e.g., scarring, hyperpigmentation, imperfections), as well as their moral character (e.g., low self-confidence, bullying). Additionally, for higher vitamin C content from various rosehip species, the traditional (i.e., infusion, maceration, Soxhlet extraction) and contemporary extraction methods (i.e., supercritical fluid extraction, microwave-assisted, ultrasonic-assisted, and enzyme-assisted extractions) are highlighted, finally choosing the best extraction method for increased bioactive compounds, with emphasis on vitamin C content. Consequently, the current research focuses on assessing the potential of rosehip extracts as medicinal agents against various skin conditions, and the use of rosehip concentrations in skincare formulations (such as toner, serum, lotion, and sunscreen). Up-to-date studies have revealed that rosehip extracts are perfect candidates as topical application products in the form of nanoemulsions. Extensive in vivo studies have revealed that rosehip extracts also exhibit specific activities against multiple skin disorders (i.e., wound healing, collagen synthesis, atopic dermatitis, melasma, and anti-aging effects). Overall, with multiple dermatological actions and efficacies, rosehip extracts and oils are promising agents that require a thorough investigation of their functioning processes to enable their safe use in the skincare industry.
Applying a non-GMO breeding approach with an identified natural variation to reduce food allergen Len c3 in Lens culinaris seeds
Authors: Song Jingpu , Mavraganis Ioannis , Shen Wenyun , Yang Hui , Zou Jitao
Published: April 2024

Lentils (Lens culinaris) are produced in diverse agroecological regions and are consumed as one of the most important food legumes worldwide. Lentils possess a nutritional profile from a human health perspective that is not only nutrient dense but also offers a better balance between protein and carbohydrates. However, lentil causes food allergy, which has been a significant concern due to increased consumption in parts of the world. Len c3, a non-specific lipid transfer protein (LTP), was identified as one of the allergens in lentil seeds. In this study, we identified an LTP gene Lcu.2RBY.4g013600 that encodes the lentil allergen Len c3. We then focused on gene screening from a collection of natural accessions to search for natural mutations of the Len c3 allergen-encoding gene. A natural lentil line M11 was identified with mutations at LcLTP3b and low accumulation of vicilin through genomic-assisted approaches. Furthermore, we generated a pool of lentil germplasms with LcLTP3b mutation background through crossing the identified lentil plant M11 with two lentil cultivars, CDC Redmoon and CDC Gold. These generated lentil hybrids can be used as a breeding resource targeting at reducing allergen risk in lentil consumption.
A bird’s-eye view: exploration of the flavin-containing monooxygenase superfamily in common wheat
Authors: Sun Sherry , Bakkeren Guus
Published: April 2024

The Flavin Monooxygenase (FMO) gene superfamily in plants is involved in various processes most widely documented for its involvement in auxin biosynthesis, specialized metabolite biosynthesis, and plant microbial defense signaling. The roles of FMOs in defense signaling and disease resistance have recently come into focus as they may present opportunities to increase immune responses in plants including leading to systemic acquired resistance, but are not well characterized. We present a comprehensive catalogue of FMOs found in genomes across vascular plants and explore, in depth, 170 wheat TaFMO genes for sequence architecture, cis-acting regulatory elements, and changes due to Transposable Element insertions. A molecular phylogeny separates TaFMOs into three clades (A, B, and C) for which we further report gene duplication patterns, and differential rates of homoeologue expansion and retention among TaFMO subclades. We discuss Clade B TaFMOs where gene expansion is similarly seen in other cereal genomes. Transcriptome data from various studies point towards involvement of subclade B2 TaFMOs in disease responses against both biotrophic and necrotrophic pathogens, substantiated by promoter element analysis. We hypothesize that certain TaFMOs are responsive to both abiotic and biotic stresses, providing potential targets for enhancing disease resistance, plant yield and other important agronomic traits. Altogether, FMOs in wheat and other crop plants present an untapped resource to be exploited for improving the quality of crops.
Functional characterization of Fagopyrum tataricum ZIP gene family as a metal ion transporter
Authors: Zhang Xinrong , Kong Jiao , Yu Lingzhi , Wang Anhu , Yang Yi , Li Xiaoyi , Wang Jianmei
Published: April 2024

The zinc/iron-regulated transporter-like proteins (ZIP) family acts as an important transporter for divalent metal cations such as Zn, Fe, Mn, Cu, and even Cd. However, their condition is unclear in Tartary buckwheat (Fagopyrum tataricum). Here, 13 ZIP proteins were identified and were predicted to be mostly plasma membrane-localized. The transient expressions of FtZIP2 and FtZIP6 in tobacco confirmed the prediction. Multiple sequence alignment analysis of FtZIP proteins revealed that most of them had 8 putative transmembrane (TM) domains and a variable region rich in histidine residues between TM3 and TM4, indicating the reliable affinity to metal ions. Gene expression analysis by qRT-PCR showed that FtZIP genes were markedly different in different organs, such as roots, stems, leaves, flowers, fruits and seeds. However, in seedlings, the relative expression of FtZIP10 was notably induced under the CdCl2 treatment, while excessive Zn2+, Fe2+, Mn2+ and Cd2+ increased the transcript of FtZIP5 or FtZIP13, in comparison to normal conditions. Complementation of yeast mutants with the FtZIP family genes demonstrate that FtZIP7/10/12 transport Zn, FtZIP5/6/7/9/10/11 transport Fe, FtZIP12 transports Mn and FtZIP2/3/4/7 transport Cd. Our data suggest that FtZIP proteins have conserved functions of transportation of metal ions but with distinct spatial expression levels.
Associations between challenging parenting behavior and creative tendencies of children: the chain mediating roles of positive emotion and creative self-efficacy
Authors: Shi Dasheng , Wang Yidi , Jin Ruining , Chu Lin
Published: April 2024

Background

Parenting behavior has been reported to be closely associated with children’s creativity, yet the association between challenging parenting behavior and children’s creative tendencies, as well as the potential mechanisms connecting the two, remains ambiguous. Based on the Social Cognitive Theory and the Self-efficacy Theory, this study aims to examine the correlation between Chinese parents’ challenging parenting behaviors and their children’s creative tendencies, as well as the chain mediating role of children’s positive emotions and creative self-efficacy.

Methods

In total, 2,647 families were surveyed with questionnaires completed by parents on the Challenging Parenting Behaviors Scale and by children on the Positive/Negative Emotions Scale, the Creative Self-efficacy Scale, and the Williams Creative Tendency Test Scale, and analyzed using structural equation modeling (SEM) in SPSS 22.0 and Mplus 8.3.

Results

The findings indicate that challenging parenting behavior has a positive correlation with children’s positive emotions, creative self-efficacy, and creative tendencies. Through positive emotions, creative self-efficacy, and a chain mediated pathway between these two variables, challenging parenting behaviors increase children’s creative tendencies.

Conclusion

The favorable impacts of challenging parenting behaviors on children’s creative tendencies, with the mediating effects of children’s positive emotions and creative self-efficacy, may help Chinese parents better grasp the mechanisms underlying this association.
Reintegration of cyber veterans: challenges and strategies for post-war transition
Authors: Virtanen Toni , Lassfolk Christina , Davydiuk Andrii , Noorma Mart
Published: April 2024

Battles in the cyber domain often lack visibility compared to the physical domain, which can lead to insufficient appreciation of its actors’ achievements by the general public and society. Nonetheless, it has become a crucial area of modern warfare in which cyber professionals defend the nation’s critical infrastructure, support other military operations and achieve military objectives that could not be attained in other domains. Although cyber combatants might not have as high a risk of injury or death as those on the front lines, they still can face traumatic events and suffer from the same types of issues after the war as any other veteran. Earlier studies on war veterans have shown they have elevated risks of mental health issues, substance use, social problems and financial difficulties which might push some individuals towards a path of crime. The cyber domain is also not limited by time or place, which has given rise to cyber volunteerism in which skilled individuals around the globe decide to assist their own country or friendly nations. This publication aims to identify the challenges cyber veterans might face when transitioning back to civilian life and develop appropriate strategies to facilitate their reintegration. It also raises the awareness of the hundreds of thousands of volunteers who can develop similar problems after the war. Without proper awareness, support and dialogue, some of these individuals can also drift towards harmful social implications such as cybercrime.
Unraveling the enigma: housekeeping gene Ugt1a7c as a universal biomarker for microglia
Authors: Kim Wonju , Kim Minji , Kim Beomsue
Published: April 2024

Background

Microglia, brain resident macrophages, play multiple roles in maintaining homeostasis, including immunity, surveillance, and protecting the central nervous system through their distinct activation processes. Identifying all types of microglia-driven populations is crucial due to the presence of various phenotypes that differ based on developmental stages or activation states. During embryonic development, the E8.5 yolk sac contains erythromyeloid progenitors that go through different growth phases, eventually resulting in the formation of microglia. In addition, microglia are present in neurological diseases as a diverse population. So far, no individual biomarker for microglia has been discovered that can accurately identify and monitor their development and attributes.

Here, we highlight the newly defined biomarker of mouse microglia, UGT1A7C, which exhibits superior stability in expression during microglia development and activation compared to other known microglia biomarkers. The UGT1A7C sensing chemical probe labels all microglia in the 3xTG AD mouse model. The expression of Ugt1a7c is stable during development, with only a 4-fold variation, while other microglia biomarkers, such as Csf1r and Cx3cr1, exhibit at least a 10-fold difference. The UGT1A7C expression remains constant throughout its lifespan. In addition, the expression and activity of UGT1A7C are the same in response to different types of inflammatory activators’ treatment in vitro.

Conclusion

We propose employing UGT1A7C as the representative biomarker for microglia, irrespective of their developmental state, age, or activation status. Using UGT1A7C can reduce the requirement for using multiple biomarkers, enhance the precision of microglia analysis, and even be utilized as a standard for gene/protein expression.
Treatment-seeking threshold and accessibility of psychiatric outpatient services in Switzerland: the relationship with stigma and self-esteem
Authors: Billian Janina , Imfeld Lukas , Roth Carl B. , Moeller Julian , Lang Undine E. , Huber Christian G.
Published: April 2024

Perceived stigmatization and low self-esteem are linked to poorer mental health outcomes, but their impact on treatment-seeking thresholds and the importance of outpatient service location remain unclear. The study included 525 outpatients of the University Psychiatric Clinic (UPK) Basel, Switzerland, of whom 346 were treated at inner city services and 179 at services located on the main site of the UPK at the outer city limits. Perceived discrimination and devaluation (PDD), self-esteem (SE), treatment-seeking threshold (TST), and accessibility were measured via a self-reported questionnaire. The PDD consisted of 12 items evaluating beliefs about the level of stigma towards individuals with mental illness in the general population on a 5-point Likert scale. SE, TST and accessibility were assessed through single-item 7-point Likert scales. PDD and SE were positively correlated (p < 0.001), suggesting that lower perceived stigma was linked to higher self-esteem, and were not associated with TST. The relationship between PDD and SE remained consistent after controlling for age, gender, and nationality. Age was negatively correlated with TST (p = 0.022), while gender did not significantly influence any of the variables. There was little variation regarding PDD, with emergencies at the site of the psychiatric clinic and substance use disorder (SUD) patients reporting higher levels of stigmatization. Emergency patients and those with SUD and personality disorder reported the lowest SE ratings. TST showed a broad range and was highest for emergency services and transcultural psychiatry patients. Differences in accessibility were mainly linked to the location, with outpatient service users in the inner city reporting better accessibility (p < 0.001) and higher SE (p = 0.009). In comparison to patients using services with planned contacts only, patients in emergency settings differed by higher TST (p = 0.018) and better ratings of accessibility (p = 0.004). In conclusion, there was a relevant amount of stigmatization, impaired self-esteem, and, for some outpatient services, high thresholds to seek treatment. Future research should explore other factors influencing TST. The findings highlight the need to address stigmatization and accessibility when planning mental health services.
A prospective longitudinal approach to examine the association between social position in childhood, adolescence, and adulthood with the control of hypertension during adulthood
Authors: Barradas Susana , Lucumi Diego I. , Mentz Graciela , Agudelo Diana Maria
Published: April 2024

Introduction

Hypertension is one of the main concerns in public health, since it is related with increased morbidity, and potential years of life lost in addition to loss of quality of life. This study aimed to assess: (1) the distribution of indicators of life course SEP in a cohort of Colombian patients with hypertension and (2) to assess the association of life course SEP and control of hypertension among this cohort of patients.

Methods

Data were obtained using the baseline survey of 258 patients from the Social Determinants and Inequities in the Control of Blood Hypertension Program (ProDSICHA). Mother occupation and housing conditions were measured with the Event History Calendar. Mother educational level was measured with the questionnaire developed by the Project on Ethnicity and Race in Latin America (PERLA). Socioeconomic position during adulthood was measured using education, occupation, and income level based in the MacArthur Network.

Results

The group with a higher lifelong social position and the group of lower lifelong social position showed better control of hypertension (OR = 1.21; p <0.05; OR = 1.33; p < .05, respectively) compared to those whose social position throughout life varied the most. No statistical differences were found in the relations between single lifetime social position variables, and hypertension control in the three time points analyzed.

Discussion

These findings warrant further research to deeper our understanding on the role of a multidimensional and cumulative approach of social position in hypertension control.
Factors associated with patients’ healthcare-seeking behavior and related clinical outcomes under China’s hierarchical healthcare delivery system
Authors: Guo Lizhu , Du Xin , Wu Huanqi , Xia Shijun , Du Jing , Kong Xiangrong , Yang Xiaohui , Wang Chi , Dong Jianzeng , Ma Changsheng , Engineer Lilly
Published: April 2024

Introduction

The hierarchical healthcare delivery system is an important measure to improve the allocation of medical resources and promote equitable distribution of basic medical and health services. It is one of the key factors in the success or failure of China’s medical reform. This study aims to analyze the factors influencing patients’ healthcare-seeking behaviors, including socioeconomic and clinical outcomes, under China’s hierarchical healthcare delivery system, and to provide potential solutions.

Methods

Patients receiving outpatient treatment in the past 14 days and inpatient care in the past 1 year were investigated. The multivariate logistic regression was used to analyze the influencing factors of patient’s medical treatment behavior selection, and to compare whether the clinical outcomes of primary medical institutions and grade A hospitals are the same.

Results

Nine thousand and ninety-eight person-times were included in the study. Of these, 4,538 patients were outpatients, 68.27% of patients were treated in primary medical institutions; 4,560 patients were hospitalized, 58.53% chose to be hospitalized in grade A hospitals. Provinces and cities, urban and rural areas, occupation, education level, medical insurance type, income, whether there are comorbid diseases, and doctors’ medical behavior are the factors affecting the choice of medical treatment behavior. Patients who choose primary medical institutions and grade A hospitals have different control levels and control rate for the blood pressure, blood lipids, blood glucose.

Conclusion

Under the hierarchical diagnosis and treatment system, the patients’ choice of hospital is mainly affected by their level of education, medical insurance types, and the inpatients are also affected by whether there are comorbid conditions. Clinical outcomes of choosing different levels of hospitals were different.
Association between mild depressive states in polycystic ovary syndrome and an unhealthy lifestyle
Authors: Li Lingling , Kang Zhiyuan , Chen Ping , Niu Baihan , Wang Yaohui , Yang Liping
Published: April 2024

Objective

Polycystic Ovary Syndrome (PCOS) is a prevalent and frequently encountered gynecological disorder. Its high variability and the complexities associated with its management often lead to psychological stress in affected women, manifesting in symptoms of depression. Embracing a healthy lifestyle is fundamental in PCOS treatment. Consistent adherence to a healthy lifestyle not only aids in improving PCOS symptoms but also plays a role in enhancing mental well-being. However, there is currently limited research examining the extent of depression, its prevalence, and its correlation with lifestyle among individuals with PCOS. Therefore, this study aims to explore the impact of lifestyle factors on the depressive state of individuals with PCOS.

Methods

This cross-sectional study gathered data from 411 individuals with PCOS at a comprehensive hospital in Henan, China. Depression status was assessed using the Hamilton Depression Scale, and demographic information as well as lifestyle habits were simultaneously collected. Univariate and multivariate analyses using logistic regression were conducted to identify risk factors associated with the depressive state in PCOS.

Results

Among the surveyed 411 individuals with PCOS, approximately 49.4% exhibited symptoms of depression, with 83.7% experiencing mild depressive symptoms. A disease duration of 1–3 years, the presence of acne, and unhealthy lifestyle factors such as high-fat diet, staying up late, lack of exercise, and mental stress emerged as significant risk factors for the onset of depressive symptoms.

Conclusion

Depressive symptoms in individuals with PCOS are predominantly mild. The risk of comorbid depression in PCOS is associated with the presence of acne, frequent high-fat diet, regular staying up late, lack of exercise, and mental stress.
Post-COVID-19 syndrome, who at risk and why: an insight from Qatar 2022
Authors: Adli Nada , Bala Mohamed , Bougmiza Mohamed Iheb , Al-Kuwari Mohamed Ghaith , Al-Khenji Abdul Hameed , Selim Nagah
Published: April 2024

Background

Despite the recovery from the COVID-19 pandemic, many people experience post-COVID-19 syndrome, which negatively impacts their health and function. This condition has become a significant public health problem that requires immediate attention.

Objective

To study the prevalence, clinical characteristics, and predictors of post-COVID-19 Syndrome in Qatar during 2022.

Methods

An analytic cross-sectional study was conducted among COVID-19 confirmed cases from January 2022 to July 2022 in Qatar. A simple random sample was employed to include (n = 588) participants from the list of cases and invited to participate in a telephone survey. The World Health Organization’s standard case definition for PCS was adopted.

Results

Out of 368, the prevalence of post-COVID-19 syndrome was 43.2% (n = 159). Most PCS cases were females (67.9%; n = 108), married (73.6%; n = 117), and university and higher educational level (83.6%; n = 133). However, 78.7% (n = 125) reported poor to moderate levels of social support. Only 30.2% (n = 48) of PCS patients had a history of chronic diseases, and 5.7% (n = 9) required hospital admission during acute illness. Among PCS cases, the most commonly reported symptoms were fatigue (75.5%), followed by anxiety (49.1%), forgetfulness (46.5%), mood alteration (45.3%), and general weakness (39.6%). The logistic regression revealed that female gender (AOR: 2.58 95%CI: 1.58–4.225, p < 0.0001), university and high educational level (AOR: 2.2, 95%CI: 1.256–3.98, p < 0.006), poor level of social support (AOR: 2.45; 95%CI: 1.55–4.13; p < 0.002), were significant predictors for PCS.

Conclusion

Post-COVID-19 syndrome may go under-recognized. More efforts are needed to raise awareness and mobilize the resources to respond to this ongoing public health problem.
Evaluating nuclear power's suitability for climate change mitigation: technical risks, economic implications and incompatibility with renewable energy systems
Authors: Präger Fabian , Breyer Christian , Fell Hans-Josef , von Hirschhausen Christian , Kemfert Claudia , Steigerwald Björn , Traber Thure , Wealer Ben
Published: April 2024

This paper presents a comprehensive analysis of the suitability of nuclear power as an option to combat the escalating climate emergency. Summarizing and evaluating key arguments, we elucidate why nuclear power is unsuitable for addressing climate change. The primary argument centers around the unresolved technical and human risks of accidents and proliferation, which are unlikely to be effectively mitigated in the future. Furthermore, we highlight the significant cost disparities between nuclear power and other non-fossil energy sources, such as solar photovoltaics and wind power, considering levelized costs of electricity. We also address the incompatibility of nuclear power with renewable energy systems, emphasizing the need for flexibility in the face of variable solar and wind resources. Alternative reactor technologies will not be available in time to make a major contribution. Nuclear power also poses challenges in power plant operation amid climate change and war. Ultimately, we argue that other motivations should be explored to explain the continued interest in nuclear power in some countries, as energy supply arguments alone are insufficient to justify new investments.
Swing-phase detection of locomotive mode transitions for smooth multi-functional robotic lower-limb prosthesis control
Authors: Haque Md Rejwanul , Islam Md Rafi , Sazonov Edward , Shen Xiangrong
Published: April 2024

Robotic lower-limb prostheses, with their actively powered joints, may significantly improve amputee users’ mobility and enable them to obtain healthy-like gait in various modes of locomotion in daily life. However, timely recognition of the amputee users’ locomotive mode and mode transition still remains a major challenge in robotic lower-limb prosthesis control. In the paper, the authors present a new multi-dimensional dynamic time warping (mDTW)-based intent recognizer to provide high-accuracy recognition of the locomotion mode/mode transition sufficiently early in the swing phase, such that the prosthesis’ joint-level motion controller can operate in the correct locomotive mode and assist the user to complete the desired (and often power-demanding) motion in the stance phase. To support the intent recognizer development, the authors conducted a multi-modal gait data collection study to obtain the related sensor signal data in various modes of locomotion. The collected data were then segmented into individual cycles, generating the templates used in the mDTW classifier. Considering the large number of sensor signals available, we conducted feature selection to identify the most useful sensor signals as the input to the mDTW classifier. We also augmented the standard mDTW algorithm with a voting mechanism to make full use of the data generated from the multiple subjects. To validate the proposed intent recognizer, we characterized its performance using the data cumulated at different percentages of progression into the gait cycle (starting from the beginning of the swing phase). It was shown that the mDTW classifier was able to recognize three locomotive mode/mode transitions (walking, walking to stair climbing, and walking to stair descending) with 99.08% accuracy at 30% progression into the gait cycle, well before the stance phase starts. With its high performance, low computational load, and easy personalization (through individual template generation), the proposed mDTW intent recognizer may become a highly useful building block of a prosthesis control system to facilitate the robotic prostheses’ real-world use among lower-limb amputees.
Insights into microorganisms, associated factors, and the oral microbiome in infective endocarditis patients
Authors: Ismail Ayden , Yogarajah Amieth , Falconer Joseph Luke , Dworakowski Rafal , Watson Samuel , Breeze Jonathan , Gunning Margaret , Khan Habib , Hussain Azhar , Howard James P. , Cheong Phoebe , Shah Mira , Nibali Luigi , Sousa Vanessa
Published: April 2024

Introduction

Infective Endocarditis (IE) is a rare, life-threatening infection of the endocardium with multisystem effects. Culprit microorganisms derived from different niches circulate through the bloodstream and attach to the endocardium, particularly the heart valves. This study aimed to investigate culprit microorganisms among a cross-sectional cohort of IE patients, their associated factors, and to explore the potential relationship to the oral microbiome.

Methods

In this observational study, we undertook a cross-sectional analysis of 392 medical records from patients diagnosed with IE. The primary outcome of this study was to analyse the association between the IE culprit microorganisms and the underlying anatomical types of IE (native valve (NVE), prosthetic valve (PVE), or cardiac device-related (CDE)). Secondary outcomes encompassed a comparative analysis of additional factors, including: the treatment approaches for IE, and the categorisation of blood cultures, extending to both genus and species levels. Additionally, we cross-referenced and compared the species-level identification of IE bacteraemia outcome measures with data from the expanded Human Oral Microbiome Database (eHOMD).

Results

A culprit microorganism was identified in 299 (76.28%) case participants. Staphylococcal infections were the most common (p < 0.001), responsible for 130 (33.16%) hospitalisations. There were 277 (70.66%) cases of NVE, 104 (26.53%) cases of PVE, and 11 (2.81%) cases of CDE. The majority of PVE occurred on prosthetic aortic valves (78/104, 75%), of which 72 (93.5%) were surgical aortic valve replacements (SAVR), 6 (7.8%) were transcatheter aortic valve implants, and one transcatheter pulmonary valve implant. Overall, underlying anatomy (p = 0.042) as well as the treatment approaches for IE (p < 0.001) were significantly associated with IE culprit microorganisms. Cross-reference between IE bacteraemia outcomes with the eHOMD was observed in 267/392 (68.11%) cases.

Conclusions

This study demonstrated that IE patients with a history of stroke, smoking, intravenous drug use, or dialysis were more likely to be infected with Staphylococcus aureus. CDE case participants and patients who had previous SAVR were most associated with Staphylococcus epidermidis. IE patients aged 78+ were more likely to develop enterococci IE than other age groups. Oral microorganisms indicated by the eHOMD are significantly observed in the IE population. Further research, through enhanced dental and medical collaboration, is required to correlate the presence of oral microbiota as causative factor for IE.
The evolving landscape: magnetic resonance imaging in active surveillance for prostate cancer management
Authors: De la Parra Irene , Gómez Rivas Juan , Gutiérrez Beatriz , Marugán María Jesús , Enikeev Dmitry , Somani Bhaskar K. , Barrera Jerónimo , Moreno-Sierra Jesús
Published: April 2024

Since overdiagnosis and overtreatment pose significant risks in managing prostate cancer (PCa), active surveillance (AS) is the most common treatment in low-risk patients. However, there is no general agreement yet on the inclusion criteria and the required follow-up. Multiparametric magnetic resonance imaging (mpMRI) of the prostate was born as a useful device in these patients both in diagnosis and follow-up, and it is widely used in daily clinical practice. We reflect on the most current evidence described in the literature on the topic, its results, and our experience.
Sandy soil reclamation technologies to improve crop productivity and soil health: a review
Authors: Musei Sylus Kipngeno , Kuyah Shem , Nyawira Sylvia , Ng’ang’a Stanley Karanja , Karugu Winifred N. , Smucker Alvin , Nkurunziza Libère
Published: April 2024

Sandy soils are characterized by low soil moisture content and nutrient retention due to high permeability, limiting crop productivity and threatening food security in arid and semi-arid regions worldwide. Various reclamation technologies have been developed to address these challenges, but their effectiveness has not been comprehensively evaluated. This systematic review evaluated the performance of 42 sandy soil reclamation technologies reported in 144 studies from 27 countries that met specified selection criteria. Performance was evaluated based on response ratio (RR) of aboveground biomass and grain yield, as indicators of productivity, and soil moisture content and soil organic carbon (SOC), as indicators of soil health. The 42 technologies employed four main soil amendments: biochar, organic amendments, organic amendments combined with biochar, and soft rock. Overall, all technologies increased productivity and improved soil health. Biochar application was found to be the most effective technology, increasing grain yield by 51.6%, aboveground biomass by 67.4%, soil moisture content by 17.3%, and SOC by 74.2%. Soft rock application increased grain yield by 20.3%, aboveground biomass by 27.6%, soil moisture content by 54.5%, and SOC by 12.8%. Organic amendments increased grain yield by 48.7%, aboveground biomass by 45.6%, soil moisture content by 20.8%, and SOC by 36.7%. However, the combination of biochar and organic amendments showed lower improvements, with increases of 25.4%, 15.6%, 1.3%, and 25.4% for grain yield, aboveground biomass, soil moisture content, and SOC, respectively. Our conclusion is that the findings provide strong evidence that sandy soil reclamation technologies can significantly improve crop productivity and food security. Considering the variability in technologies responses across continents, there is need for further research to determine the optimal technology for specific locations, crops, and management practices.
Ergonomics assessment of drudgery in rice-wheat production system in India: a case study of women farmers
Authors: Joshi Pratibha , Mahra Girijesh Singh , Jethi Renu , Satyapriya  , Singh Rahul , Bishnoi Sitaram , Sahu Subhashree , Barua Sukanya , Sarkar Sujit , Burman Rajarshi Roy
Published: April 2024

Farm women are often forced to work in extremely hazardous conditions due to their limited access to improved agricultural technologies. This circumstance makes agricultural work physically demanding, requiring significant physiological effort and the maintenance of good posture. It is also very exhausting, time-consuming, and stressful. The study was designed to evaluate and quantify the drudgery involved in the rice-wheat production system for rural women. Three replications of a 10-min work cycle without a break were used to assess the physiological and postural demands of various farm tasks on the female workers. Observations were recorded on farm women workers who were in normal health, without any major illness, and regularly involved in farm operations. In the attempt to obtain and analyze the prioritized drudgery experiences in crop production activities through drudgery assessment and reduction, various ergonomically sound farm tools and implements were provided for crop cultivation and intercultural operations. Data indicating musculoskeletal disorders were analyzed by ergonomics assessment of postural and biomechanical assessments using the Human Physical Drudgery Index (HPDI), resulting in the maximum drudgery reflecting very high risk in transplanting (48.4%), followed by threshing (47.2%), load carrying (46.00%), and harvesting (45.14%). For physiological ergonomics quantifications, the most drudgery-prone activities in the rice-wheat production system, i.e., transplanting, harvesting, threshing & post-harvest, and load carrying, were evaluated, and it was found that drudgery is caused by different activities with reflects working energy expenditure rate ranging from ~7.00 to 12.00 (kJ/min) and total cardiac cost of work (TCCW) ~ 331.00 to 524.00. Multivariate regression analysis was employed to drive relationships between energy expenditure rate (dependent variable) and other independent variables, such as age, body mass index (BMI), mid-upper arm circumference (MUAC), calf circumference (CC), skinfold measurements, body density (D), % body fat, fat mass, and fat-free mass (kg). It was found that energy expenditure rate during various crop production practices is positively correlated with independent variables (R = 0.721, R2 = 0.520, Adjusted R2 = 0.518, Standard Error of Estimate = 0.0324, Durbin-Watson = 1.531). It was found that with higher physiological parameters, the corresponding energy expenditure is maximized relating to the drudgery in respective agricultural activities. The present study addressed the magnitude of drudgery for women farmers in the rice-wheat production system and its mitigation strategy.
Biosurfactants as templates to inspire new environmental and health applications
Authors: Vigil Toriana N. , Felton Samantha M. , Fahy William E. , Kinkeade Mason A. , Visek Alexandra M. , Janiga Abigail R. , Jacob Sarah G. , Berger Bryan W.
Published: April 2024

Life exists at an interface. One of the key characteristics of biological cells is compartmentalization, which is facilitated by lipids that create a water-impenetrable barrier to control transport of materials across the hydrophilic-hydrophobic interface. Microbial systems utilize a rich diversity of surfactants beyond lipids to adapt to an environmental niche, modify the properties of an interface, facilitate solubilization of nutrients for metabolism and as antimicrobials. As such, they are a fascinating class of biomolecules to study in terms of how effectiveness in an application or niche environment depends on sequence, structure and chemical properties. Moreover, there is increasing appreciation of the negative health and environmental impacts petrochemical-based surfactants can have, such as soil erosion and toxicity to plants and aquatic life, as well as the carbon footprint and associated greenhouse gas emissions associated with petrochemical surfactant manufacturing. In this review, we discuss the properties of biosurfactants and applications, and highlight key glycolipid-, protein- and peptide-based surfactants described in literature as examples of biosurfactants with unique potential and applications. As society looks towards the transition to a circular bioeconomy, we are excited by the potential of synthetic biology to develop new materials such as biosurfactants to facilitate this important transition.
Benefits and Difficulties of Implementing Family-Farming Food Purchases in the Brazilian National School Feeding Program
Authors: Tuliende Mónica Isabel Eduardo Domingos , Martinelli Suellen Secchi , Soares Panmela , Fabri Rafaela Karen , Bianchini Vitória Uliana , Cavalli Suzi Barletto
Published: April 2024

Objectives: To explore the opinions of Brazilian National School Feeding Program (NSFP) nutritionists concerning the benefits and difficulties of implementing family-farming food purchases for the school feeding program.

Methods: Exploratory and descriptive qualitative study conducted through the analysis of inductive content of open interviews carried out with technically responsible nutritionists of the School Feeding Program of 21 municipalities in Southern Brazil.

Results: The qualitative analysis of the interviews resulted in 17 codes grouped into four categories that show the opinion of nutritionists on the benefits and difficulties of purchasing family-farming food: 1. increasing the visibility of rural areas and 2. improving the quality of food provided in school meals; 3. low product availability and 4. limited infrastructure for production and delivery.

Conclusion: According to nutritionists, purchasing family-farming food in NSFP can increase the supply of healthy food in schools and stimulate rural development. However, efforts are needed to adjust institutional food demands for local food production and improve infrastructure for food production and distribution.
Experimental Investigation of the Mechanical Behavior of the Strain Isolation Pad in Thermal Protection Systems under Tension
Authors: Lu Maoxu , Wu Zhenqiang , Hao Ziqing , Liu Liu
Published: April 2024

A strain isolation pad is a critical connection mechanism that enables deformation coordination between the rigid thermal insulation tile and the primary structure in the thermal protection system of a reusable hypersonic vehicle. An experimental investigation has been conducted to determine the static, loading–unloading, and high-cycle fatigue (HCF) responses of the SIP with 0.2 mm adhesive under through-thickness tension at room temperature. The contributions of the rigid thermal insulation tile and metallic substructure have not been considered so far. The results indicate that the tensile behavior of the SIP joint is highly nonlinear. The static and fatigue tensile failures both initiate from the corner close to the adhesive/SIP interface due to the stress concentration and the edge effect. The uniform breakage of the aramid fiber can be seen on the cross-section. A novel method is proposed to quantify the residual strain due to the short-time ratcheting effect of the SIP joint in the initial loading–unloading tensile response. As the number of fatigue cycles increases, the thickness of the SIP joint continues to increase until failure. An explicit expression associated with the growth of SIP joint thickness, fatigue cycle number, and peak cyclic stress is established. The turning point of the thickness growth rate with the fatigue cycle number is proposed as a new fatigue failure index for the SIP joint under tensile fatigue, and a fatigue life prediction model is developed.
The Identification of Drought Tolerance Candidate Genes in Oryza sativa L. ssp. Japonica Seedlings through Genome-Wide Association Study and Linkage Mapping
Authors: Liu Tao , Li Shuangshuang , Du Haoqiang , Cui Jingnan , Xu Shanbin , Wang Jingguo , Liu Hualong , Zou Detang , Lu Wenhe , Zheng Hongliang
Published: April 2024

Drought stress poses a significant threat to rice production, necessitating the identification of genes associated with drought tolerance. This study employed a combination of genome-wide association study (GWAS) and linkage mapping to pinpoint seedling drought tolerance genes in Japonica rice. Using the leaf rolling scale (LRS) as the phenotypic index, we assessed rice drought tolerance under polyethylene glycol-induced drought during the seedling stage. A lead SNP C8_28933410 by GWAS was identified, which was located within qLRS-8-1 identified by linkage mapping on chromosome 8. Combing the LD block analyses and QTL interval, a 138.6 kb overlap interval was considered as the candidate region. Haplotype analysis, qRT-PCR, sequence analysis, and mutant phenotype verification led to the speculation that LOC_Os08g05520 is a candidate gene associated with drought tolerance. Our findings provide a valuable reference for breeders aiming to enhance rice drought tolerance.
Investigating the Impacts of Wastewaters on Lettuce (Lactuca sativa) Seed Germination and Growth
Authors: Reynolds Liam P. , Leme Vitória F. C. , Davidson Paul C.
Published: April 2024

There is an opportunity for agriculture to utilize the many different waste streams in our world and capitalize on what would otherwise be viewed as waste products. Hydrothermal liquefaction (HTL) is an emerging technology for converting wet biomass to bio-crude oil, while aquaponics is a practice tracing back to indigenous communities around the world; both technologies have the potential to sustainably provide the necessary nutrients for crop growth. Food systems worldwide are actively transitioning to address the many challenges of climate change in a sustainable and efficient manner. Urban agriculture (UA) has the potential to generate localized crops in densely populated areas year-round, but has its challenges, involving high capital requirements, especially for vertical farming and controlled-environment agriculture, and being energy intensive due to artificial lighting and fossil fuel-based synthetic fertilizers. This study investigated the potential for aquaponic and HTL effluents to be used in hydroponic systems through a seed germination screening experiment. Buttercrunch lettuce (Lactuca sativa L.) seeds were placed in Ziploc plastic bags on paper towels saturated with the wastewater treatments for 10 days while their total length of growth was routinely measured from the tip of the root to the tip of the cotyledons. The Chicago High School for Agricultural Sciences (CHSAS) aquaponic effluent with a 5.8× times higher nitrate concentration and 4.25× higher ammonia concentration outperformed the Bevier aquaponic effluent and improved any other source water it was combined with. Results also showed that seed germination was not inhibited in the presence of 2–8% solutions of hydrothermal liquefaction aqueous phase (HTL-AP), which performed on par with standard hydroponic fertilizer; solutions of a higher percentage, though, may lead to inhibitory effects in plants, and those of a lower percentage may not provide enough nutrients in the proper forms to sustain plant growth. However, the nutrient analyses revealed that there is still much to investigate regarding the combination of wastewaters to provide a complete, well-rounded, and sustainable source for hydroponic crop production.
Do Living Mulches or Environmental Conditions Have a Greater Impact on the External Quality of the Apple Fruit ‘Chopin’ Cultivar?
Authors: Licznar-Malanczuk Maria , Baluszynska Urszula Barbara
Published: April 2024

Research was carried out to assess the yield and quality of fruits from the new Polish apple tree ‘Chopin’—a ‘green peel’, scab-resistant cultivar under grass living mulch management. Blue fescue and red fescue were tested in experiment no. 1. In experiment no. 2, meadow grass and perennial ryegrass were used. Every species of grass was sown in two doses of 50 and 150 kg per ha. Herbicide fallow was introduced as a control in both experiments. Strongly variable temperatures and precipitations in the years of evaluation made it possible to estimate year—a function of variable environmental conditions—as an additional experimental factor. An unexpected effect of the presence of living mulch was its significant impact on the appearance of blush on the ‘green peel’ fruit. However, living mulches had little effect on weight and fruit size. Cool days during apple ripening enhanced the process of fruit skin red coloration. The effect of both agrotechnical and environmental factors on fruit quality was more visible in the case of less vigorous trees, which were more susceptible to experimental, stressful conditions. However, increasing the sowing dose of each grass seed did not influence red blushing, weight, or fruit size. An additional difficulty for the trees was the competition caused by the early germination of these living grass mulches, reinforced by the presence of Trifolium repens L.
The Economic and Environmental Aspects of Miscanthus × giganteus Phytomanagement Applied to Non-Agricultural Land
Authors: Mamirova Aigerim , Pidlisnyuk Valentina
Published: April 2024

Miscanthus × giganteus (M × g) is a promising energy crop in phytotechnology with biomass production. Despite considerable vegetation and harvest under varying climate conditions and across different soils, field-scale studies on utilising M × g remain scarce. Analysing the literature and our own findings, this study intends to highlight the potential of M × g phytotechnology for revitalising non-agricultural lands (NAL), including brownfields, and illustrate the expediency of applying biochar to enhance biomass yield, energy efficiency, and economic feasibility. To validate the feasibility of M × g production on brownfields, two scenarios within the value chain “biomass–biogas–electricity” for green harvest were examined. The assumptions were as follows: (1) a methane yield of 5134 m3 ha−1 y−1, and (2) substrate-specific methane yields of 247 and 283 mL (g oDM)−1 for the first and subsequent years, respectively. The findings suggest that Scenario 2 is better suited for cultivating M × g on brownfields/NAL, being more sensitive and eliminating inaccuracies and the generalisations of results. From the third year onward, the revenue of M × g production on biochar-amended brownfields showed greater potential for future profitability. Future research should confirm the positive trend in the energy efficiency ratio of M × g phytotechnology on a larger scale, particularly in real brownfield applications.