bluuebunny/crossref_metadata_2025 huggingface dataset:
Modified Conditional Restricted Boltzmann Machines for Query Recommendation in Digital Archives
Authors: Wang Jiayun , Batjargal Biligsaikhan , Maeda Akira , Kawagoe Kyoji , Akama Ryo
Published: February 2023

Digital archives (DAs) usually store diverse expert-level materials. Nowadays, access to DAs is increasing for non-expert users, However, they might have difficulties formulating appropriate search queries to find the necessary information. In response to this problem, we propose a query log-based query recommendation algorithm that provides expert knowledge to non-expert users, thus supporting their information seeking in DAs. The use case considered is one where after users enter some general queries, they will be recommended semantically similar expert-level queries in the query logs. The proposed modified conditional restricted Boltzmann machines (M-CRBMs) are capable of utilizing the rich metadata in DAs, thereby alleviating the sparsity problem that conventional restricted Boltzmann machines (RBMs) will face. Additionally, compared with other CRBM models, we drop a large number of model weights. In the experiments, the M-CRBMs outperform the conventional RBMs when using appropriate metadata, and we find that the recommendation results are relevant to the metadata fields that are used in M-CRBMs. Through experiments on the Europeana dataset, we also demonstrate the versatility and scalability of our proposed model.
Influence of Sex and Dominant Side on the Reliability of Two Trunk Rotator Exercises
Authors: Rodríguez-Perea Angela , Jerez-Mayorga Daniel , Morenas-Aguilar María Dolores , Martínez-García Darío , Chirosa-Ríos Ignacio Jesús , Chirosa-Ríos Luis Javier , Reyes-Ferrada Waleska
Published: February 2023

Background: A method to assess the influence of sex and side testing on trunk rotator muscles has not been described. The purpose was to analyze the influence of sex and dominant and non-dominant sides (DS-NDS) on the reliability of two trunk rotator exercises and to study the relationship between the DS-NDS of two trunk rotator strength exercises. Methods: The reliability of the horizontal cable woodchop (HCW) and low cable woodchop (LWC) exercises was studied using a test-retest design with 51 physically active students. Isokinetic and isometric strength were assessed with a functional electromechanical dynamometer. Results: There were significant differences in reliability between male and female HCW and no significant differences in reliability between the average of the DS-NDS in HCW and LCW. There were no significant differences between the DS-NDS in the sex of HCW, and the strength of the two exercises showed no significant differences except for two conditions assessed. Very large to extremely large correlations were observed between sides in the strength of two exercises (r = 0.71–0.91). Conclusions: This test is handy for physical trainers or coaches to know the strength of the trunk rotators of their athletes.
The Semiotics of Willem de Kooning’s Easter Monday
Authors: Cernuschi Claude
Published: February 2023

Critics have frequently employed strict binary schemes to explain Abstract Expressionism’s singular contributions to art history: the victory of abstraction over figuration, avant-garde over kitsch, pure art over anecdotal illustration, action over premeditation, or escapist detachment over direct political engagement. Taking Willem de Kooning’s Easter Monday as a case study, this paper will question the efficacy of such dyadic explanations to encapsulate the diversity of New York School practice. Easter Monday includes both figural and abstract elements, some that parade the work’s impulsive and spontaneous character and others that were created by a photo-mechanical process. Some celebrate the artist’s personal and idiosyncratic touch, others the impersonality of popular forms of advertising. In contradistinction, the semiotic terminology of C.S. Pierce reveals not only multiple points of intersection with de Kooning’s work; it also effectively identifies and differentiates the plurality of elements the artist conjoined in a single visual field, some of which qualify as iconic, indexical, symbolic, or even as hybrid combinations of the above. These more elastic descriptors, it will be argued, are well-suited to address de Kooning’s variegated surfaces: they can address his accommodation of diverse techniques, as well as the multiple ways the artist constructed meaning and responded to popular culture.
XUV Fluorescence Detection of Laser-Cooled Stored Relativistic Ions
Authors: Ueberholz Ken , Bozyk Lars , Bussmann Michael , Eizenhöfer Noah , Hannen Volker , Horst Max , Kiefer Daniel , Kiefer Nils , Klammes Sebastian , Kühl Thomas , Langfeld Benedikt , Loeser Markus , Ma Xinwen , Nörtershäuser Wilfried , Sánchez Rodolfo , Schramm Ulrich , Siebold Mathias , Spiller Peter , Steck Markus , Stöhlker Thomas , Walther Thomas , Wang Hanbing , Weinheimer Christian , Wen Weiqiang , Winters Danyal
Published: February 2023

An improved moveable in vacuo XUV fluorescence detection system was employed for the laser cooling of bunched relativistic (β = 0.47) carbon ions at the Experimental Storage Ring (ESR) of GSI Helmholtzzentrum Darmstadt, Germany. Strongly Doppler boosted XUV fluorescence (∼90 nm) was emitted from the ions in a forward light cone after laser excitation of the 2s–2p transition (∼155 nm) by a new tunable pulsed UV laser system (257 nm). It was shown that the detected fluorescence strongly depends on the position of the detector around the bunched ion beam and on the delay (∼ns) between the ion bunches and the laser pulses. In addition, the fluorescence information could be directly combined with the revolution frequencies of the ions (and their longitudinal momentum spread), which were recorded using the Schottky resonator at the ESR. These fluorescence detection features are required for future laser cooling experiments at highly relativistic energies (up to γ∼ 13) and high intensities (up to 1011 particles) of ion beams in the new heavy ion synchrotron SIS100 at FAIR.
Partially Linear Additive Hazards Regression for Bivariate Interval-Censored Data
Authors: Zhang Ximeng , Zhao Shishun , Hu Tao , Sun Jianguo
Published: February 2023

In this paper, we discuss regression analysis of bivariate interval-censored failure time data that often occur in biomedical and epidemiological studies. To solve this problem, we propose a kind of general and flexible copula-based semiparametric partly linear additive hazards models that can allow for both time-dependent covariates and possible nonlinear effects. For inference, a sieve maximum likelihood estimation approach based on Bernstein polynomials is proposed to estimate the baseline hazard functions and nonlinear covariate effects. The resulting estimators of regression parameters are shown to be consistent, asymptotically efficient and normal. A simulation study is conducted to assess the finite-sample performance of this method and the results show that it is effective in practice. Moreover, an illustration is provided.
Multi-Omics Reveal Interplay between Circadian Dysfunction and Type2 Diabetes
Authors: Tiwari Ashutosh , Rathor Priya , Trivedi Prabodh , Ch Ratnasekhar
Published: February 2023

Type 2 diabetes is one of the leading threats to human health in the 21st century. It is a metabolic disorder characterized by a dysregulated glucose metabolism resulting from impaired insulin secretion or insulin resistance. More recently, accumulated epidemiological and animal model studies have confirmed that circadian dysfunction caused by shift work, late meal timing, and sleep loss leads to type 2 diabetes. Circadian rhythms, 24-h endogenous biological oscillations, are a fundamental feature of nearly all organisms and control many physiological and cellular functions. In mammals, light synchronizes brain clocks and feeding is a main stimulus that synchronizes the peripheral clocks in metabolic tissues, such as liver, pancreas, muscles, and adipose tissues. Circadian arrhythmia causes the loss of synchrony of the clocks of these metabolic tissues and leads to an impaired pancreas β-cell metabolism coupled with altered insulin secretion. In addition to these, gut microbes and circadian rhythms are intertwined via metabolic regulation. Omics approaches play a significant role in unraveling how a disrupted circadian metabolism causes type 2 diabetes. In the present review, we emphasize the discoveries of several genes, proteins, and metabolites that contribute to the emergence of type 2 diabetes mellitus (T2D). The implications of these discoveries for comprehending the circadian clock network in T2D may lead to new therapeutic solutions.
Novel Inhibitory Role of Fenofibric Acid by Targeting Cryptic Site on the RBD of SARS-CoV-2
Authors: Huang Jianxiang , Chan Kevin C. , Zhou Ruhong
Published: February 2023

The emergence of the recent pandemic causing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created an alarming situation worldwide. It also prompted extensive research on drug repurposing to find a potential treatment for SARS-CoV-2 infection. An active metabolite of the hyperlipidemic drug fenofibrate (also called fenofibric acid or FA) was found to destabilize the receptor-binding domain (RBD) of the viral spike protein and therefore inhibit its binding to human angiotensin-converting enzyme 2 (hACE2) receptor. Despite being considered as a potential drug candidate for SARS-CoV-2, FA’s inhibitory mechanism remains to be elucidated. We used molecular dynamics (MD) simulations to investigate the binding of FA to the RBD of the SARS-CoV-2 spike protein and revealed a potential cryptic FA binding site. Free energy calculations were performed for different FA-bound RBD complexes. The results suggest that the interaction of FA with the cryptic binding site of RBD alters the conformation of the binding loop of RBD and effectively reduces its binding affinity towards ACE2. Our study provides new insights for the design of SARS-CoV-2 inhibitors targeting cryptic sites on the RBD of SARS-CoV-2.
The Cultivation Effect of Architectural Heritage YouTube Videos on Perceived Destination Image
Authors: Song Lingxi , Li Rita Yi Man , Wareewanich Thitinant
Published: February 2023

A positive and robust destination image endows a competitive advantage. As architecture appeals to tourists, it may be helpful to improve people’s perceptions of a place’s image. Social media cultivates the destination image. This study focused on the interrelationship of architectural heritage and destination image and aimed to investigate the potential of architectural heritage YouTube videos in communicating and cultivating the destination image of Beijing. It collected and analysed 2237 YouTube videos in French and 25,234 comments related to Beijing’s architectural heritage in tourism. The social networks analysis found that viewers lacked interaction. The sentiment analysis via artificial intelligence findings demonstrate that most video descriptions (94%) and viewers’ comments (91%) had a neutral or complimentary attitude on the buildings’ heritage in Beijing. The keyword in context (KWIC) results found that when people viewed Beijing’s architectural heritage tourism relevant videos and were fascinated by the content, they associated it with China rather than the city where the architectural heritage was located. This indicates a cultivation effect on the destination country image of China. The significance of this study is to provide suggestions to improve a country’s destination image with YouTube via architectural heritage. It also raises the importance and social awareness of architectural heritage conservation and provides insights for policymakers on destination country image building.
Surface Activation of Wax-Based Additives to Enhance Asphalt Rheological Properties via Rotating Plasma Treatment
Authors: Chen Qiwei , Li Yanqing , Lin Zengyao , Yu Huayang
Published: February 2023

Wax-based additives have been widely used in asphalt pavement for their preferable environmental benefits. However, poor compatibility between wax-based warm mix additives and asphalt easily leads to precipitation of wax and cracking of asphalt pavement. Plasma treatment can effectively modify the surface of various materials. This study applies plasma treatment to improve the surface properties of wax-based additives for compatibility improvement in asphalt binder. Compatibility of two different wax-base additives in asphalt binder before and after surface treatment is investigated via cigar tube test and morphology test. In parallel, rheological properties of wax-modified asphalt are characterized from the perspectives of rotational viscosity, rutting resistance, and fatigue performance. Results show the enhanced surface roughness and chemical activity of wax-based additives after plasma treatment. The adhesion between waxes and the asphalt matrix is significantly improved. Waxes within binder are uniformly dispersed after plasma treatment. The incorporation of surface activated wax helps to promote the viscosity reduction of asphalt binder. Furthermore, the high-temperature performance of wax-based asphalt after surface activation treatment of wax is significantly improved, especially for fatty acid amide waxes. As for fatigue performance, plasma treatment improves the fatigue resistance from a compatibility perspective. Therefore, plasma has great promise for facilitating wax-modified asphalt properties from a compatibility perspective.
Participation as a Tool for the Sustainable Redesign of Vacant Heritage: The Case of Politiebureau Groningen Centrum
Authors: Liu Chi , dos Santos Gonçalves Joana , Quist Wido
Published: February 2023

This paper explores the opportunities for locals’ participation as a tool for the sustainable redevelopment of vacant heritage. It focuses on the Politiebureau Groningen Centrum (The Netherlands) as a case study to apply a novel approach to engage community participation in architectural redesign. It fills the academic gap on participation in heritage building redesign lacking diversity in stakeholder perspectives and overcomes some of the current participatory design tools’ downsides, identified in the previous literature: lack of transparent communication and high requirement for participants. This research employs a combination of methods structured by sets of divergent and convergent phases. Cognitive mapping, semi-structured interviewing, and a 2,5D model game were tested in the research for inquiry and redesign testing, the two key participatory stages. The research outcomes include participants’ perceptions and remembrance of the site for generating redesign scenarios, the common ground in their scenario preferences, and their contrasting attitudes toward the overall material and the specific elements. The 2,5D model game tool turns out effective in transparently delivering the redesign possibilities to participants and lowering the requirements of time, language skill, and learning capacity, thus being easily repeatable for other sites and participants to boost social and community values. Future research recommendations are given on applying the approach to larger samples covering all the minorities to get in-depth knowledge on the community’s collective perspectives in relation to their sociodemographic characteristics and validate the hypothesis on their preferences toward materials and elements.
Hybrid Materials Based on Imidazo[4,5-b]porphyrins for Catalytic Oxidation of Sulfides
Authors: Abdulaeva Inna A. , Birin Kirill P. , Chassagnon Remi , Bessmertnykh-Lemeune Alla
Published: February 2023

Heterogenized metalloporphyrin catalysts for oxidation reactions are extensively explored to improve chemical production. In this work, manganese meso-tetraarylporphyrins were immobilized on hydrated mesoporous titanium dioxide (SBET = 705 m2 g−1) through carboxylate or phosphonate anchoring groups separated from the macrocycle by the 2-arylimidazole linker fused across one of the pyrrolic rings of the macrocycle. The element composition of two mesoporous hybrid materials thus obtained were investigated and the integrity of the immobilized complexes was shown by different physicochemical methods. Finally, the catalytic efficiency of the more stable material Mn(TMPIP)/TiO2 with the phosphonate anchor was evaluated in the selective oxidation of sulfides to sulfoxides by molecular oxygen in the presence of isobutyraldehyde (IBA). The heterogenized complex has shown excellent catalytic activity exhibiting a turnover (TON) of ~1100 in a single catalytic run of the sulfoxidation of thioanisole. The catalyst was successfully reused in seven consecutive catalytic cycles.
Synthesis of Hollow Leaf-Shaped Iron-Doped Nickel–Cobalt Layered Double Hydroxides Using Two-Dimensional (2D) Zeolitic Imidazolate Framework Catalyzing Oxygen Evolution Reaction
Authors: Nguyen Quoc Hao , Im Kyungmin , Kim Jinsoo
Published: February 2023

Layered double hydroxides (LDHs) have been reported as one of the most effective materials for oxygen evolution reaction (OER) catalysts, which are prone to hydrolysis and oxidation under OER conditions. Metal–organic frameworks (MOFs) are porous materials with high crystallinity and internal surface area. The design of LDHs based on MOFs has attracted increasing attention owing to their high surface area, exposed catalysis sites, and fast charge/mass transport kinetics. Herein, we report a novel approach to fabricate a leaf-shaped iron-doped nickel–cobalt LDH (L-Fe-NiCoLDH) derived from a two-dimensional (2D) zeolitic imidazolate framework with a leaf-like morphology (ZIFL). Iron doping played a significant role in enhancing the specific surface area, affecting the OER performance. L-Fe-NiCoLDH showed high OER performance with an overpotential of 243 mV at 10 mA cm−2 and high durability after 20 h. The design of LDHs based on the leaf morphology of MOFs offers tremendous potential for improving OER efficiency.
When Pediatric Headaches Are Not Benign—Eye Findings
Authors: Karimaghaei Sam , Rook Brita S.
Published: February 2023

Headache is the most common neurologic complaint that presents to the pediatrician. While most headaches are benign in nature, patients must be carefully evaluated to rule out life- or vision-threatening causes. Non-benign etiologies of headache may exhibit ophthalmologic signs and symptoms that can help narrow the differential diagnosis. It is also important for physicians to know in what situations appropriate ophthalmologic evaluation is necessary, such as evaluating for papilledema in the setting of elevated intracranial pressure. In this article we discuss life- and/or vision-threatening etiologies of headache, including infection, autoimmune disease, cerebrovascular pathologies, hydrocephalus, intracranial neoplasia, and idiopathic intracranial hypertension, and their associated ophthalmologic manifestations. Due to less familiarity of the disease amongst primary care providers, we discuss pediatric idiopathic intracranial hypertension in more comprehensive detail.
Choledochal Cyst Excision in Infants—A Retrospective Study
Authors: Kowalski Adam , Kowalewski Grzegorz , Kaliciński Piotr , Pankowska-Woźniak Katarzyna , Szymczak Marek , Ismail Hor , Stefanowicz Marek
Published: February 2023

A choledochal cyst is a rare malformation primarily diagnosed in children. The only effective therapy remains surgical cyst resection followed by Roux-en-Y hepaticojejunostomy. Treating asymptomatic neonates remains a point of discussion. Between 1984 and 2021, we performed choledochal cyst (CC) excision in 256 children at our center. Out of this group, we retrospectively reviewed the medical records of 59 patients who were operated on under one year of age. Follow-up ranged from 0.3 to 18 years (median 3.9 years). The preoperative course was asymptomatic in 22 (38%), while 37 patients (62%) had symptoms before surgery. The late postoperative course was uneventful in 45 patients (76%). In symptomatic patients, 16% had late complications, while in asymptomatic patients, only 4%. Late complications were observed in the laparotomy group in seven patients (17%). We did not observe late complications in the laparoscopy group. Early surgical intervention is not followed by a high risk of complications and may prevent the onset of preoperative complications, giving excellent early and long-term results, especially after minimally invasive laparoscopic surgery.
An Improved Multilabel k-Nearest Neighbor Algorithm Based on Value and Weight
Authors: Wang Zhe , Xu Hao , Zhou Pan , Xiao Gang
Published: February 2023

Multilabel data share important features, including label imbalance, which has a significant influence on the performance of classifiers. Because of this problem, a widely used multilabel classification algorithm, the multilabel k-nearest neighbor (ML-kNN) algorithm, has poor performance on imbalanced multilabel data. To address this problem, this study proposes an improved ML-kNN algorithm based on value and weight. In this improved algorithm, labels are divided into minority and majority, and different strategies are adopted for different labels. By considering the label of latent information carried by the nearest neighbors, a value calculation method is proposed and used to directly classify majority labels. Additionally, to address the misclassification problem caused by a lack of nearest neighbor information for minority labels, weight calculation is proposed. The proposed weight calculation converts distance information with and without label sets in the nearest neighbors into weights. The experimental results on multilabel datasets from different benchmarks demonstrate the performance of the algorithm, especially for datasets with high imbalance. Different evaluation metrics show that the results are improved by approximately 2–10%. The verified algorithm could be applied to a multilabel classification of various fields involving label imbalance, such as drug molecule identification, building identification, and text categorization.
Robot-Assisted Radical Cystectomy: A Single-Center Experience and a Narrative Review of Recent Evidence
Authors: Rocco Bernardo , Garelli Giulia , Assumma Simone , Turri Filippo , Sangalli Mattia , Calcagnile Tommaso , Gaia Giorgia , Terzoni Stefano , Oliviero Guglielmo , Stroppa Daniele , Panio Enrico , Sarchi Luca , del Nero Alberto , Bozzini Giorgio , Grasso Angelica , Dell’Orto Paolo , Sighinolfi Maria Chiara
Published: February 2023

Radical cystectomy represents one of the most challenging surgical procedures, exhibiting a high morbidity rate. The transition to minimally invasive surgery in the field has been steep, due to either the technical complexity and prior concerns of atypical recurrences and/or peritoneal spread. More recently, a larger series of RCTs has proven the oncological safety of robot-assisted radical cystectomy (RARC). Beyond survival outcomes, the comparison between RARC and open surgery in terms of peri-operative morbidity is still ongoing. We present a single-center experience of RARC with intracorporeal urinary diversion. Overall, 50% of patients had an intracorporeal neobladder reconstruction. The series confirms a low rate of complications (Clavien Dindo ≥ IIIa 7.5%) and wound infections (2.5%) and the absence of thromboembolic events. No atypical recurrences were found. To discuss these outcomes, we reviewed the literature related to RARC including level-1 evidence. PubMed and Web of Science searches were performed using the medical subject terms “robotic radical cystectomy” and “randomized controlled trial (RCT)”. Six unique RCTs comparing robot and open surgery were found. Two clinical trials dealt with RARC with an intracorporeal reconstruction of UD. Pertinent clinical outcomes are summarized and discussed. In conclusion, RARC is a complex but feasible procedure. The transition from extracorporeal urinary diversion (UD) to a complete intracorporeal reconstruction could be the key to improving peri-operative outcomes and reducing the whole morbidity of the procedure.
A Framework for Understanding Unstructured Financial Documents Using RPA and Multimodal Approach
Authors: Cho Seongkuk , Moon Jihoon , Bae Junhyeok , Kang Jiwon , Lee Sangwook
Published: February 2023

The financial business process worldwide suffers from huge dependencies upon labor and written documents, thus making it tedious and time-consuming. In order to solve this problem, traditional robotic process automation (RPA) has recently been developed into a hyper-automation solution by combining computer vision (CV) and natural language processing (NLP) methods. These solutions are capable of image analysis, such as key information extraction and document classification. However, they could improve on text-rich document images and require much training data for processing multilingual documents. This study proposes a multimodal approach-based intelligent document processing framework that combines a pre-trained deep learning model with traditional RPA used in banks to automate business processes from real-world financial document images. The proposed framework can perform classification and key information extraction on a small amount of training data and analyze multilingual documents. In order to evaluate the effectiveness of the proposed framework, extensive experiments were conducted using Korean financial document images. The experimental results show the superiority of the multimodal approach for understanding financial documents and demonstrate that adequate labeling can improve performance by up to about 15%.
Design Optimization of an Axial Flux Magnetic Gear by Using Reluctance Network Modeling and Genetic Algorithm
Authors: Ruiz-Ponce Gerardo , Arjona Marco A. , Hernandez Concepcion , Escarela-Perez Rafael
Published: February 2023

The use of a suitable modeling technique for the optimized design of a magnetic gear is essential to simulate its electromagnetic behavior and to predict its satisfactory performance. This paper presents the design optimization of an axial flux magnetic gear (AFMG) using a two-dimensional (2D) magnetic equivalent circuit model (MEC) and a Multi-objective Genetic Algorithm (MOGA). The proposed MEC model is configured as a meshed reluctance network (RN) with permanent magnet magnetomotive force sources. The non-linearity in the ferromagnetic materials is accounted for by the MEC. The MEC model based on reluctance networks (RN) is considered to be a good compromise between accuracy and computational effort. This new model will allow a faster analysis and design for the AFMG. A multi-objective optimization is carried out to achieve an optimal volume-focused design of the AFMG for future practical applications. The performance of the optimized model is then verified by establishing flux density comparisons with finite element simulations. This study shows that with the combination of an MEC-RN model and a GA for its optimization, a satisfactory accuracy can be achieved compared to that of the finite element analysis (FEA), but with only a fraction of the computational time.
Experimental Study of Frost Crystals Dendrite Growth on Two Neighboring Separate Frozen Water Drops on a Cryogenic Cold Surface under Natural Convection Conditions
Authors: Yu Fengjiao , Liu Zhongliang , Li Yanxia , Chen Yanling , Li Yi
Published: February 2023

The effects of cold surface temperature, wet air state (temperature and humidity) and original drop size on frost dendrites growth of two neighboring separate frozen water drops of same size under natural convection conditions were investigated by quantitative measurement. It was determined that for different cold plate surface temperature conditions, i.e., the ordinary-low temperature and the cryogenic temperature range, the frost formation mechanism is different. Under the conditions that the air temperature is not too high and absolute humidity is not too excessive, the influence of frozen water drop size on the longest dendrite of frost crystals becomes more and more obvious with the decrease in cold plate temperature. The changes in air temperature and relative humidity both change air absolute humidity, so they have similar effects on the growth of dendrites. However, the effect of wet air state on the growth of frost dendrites is not monotonous, which needs to be considered comprehensively in combination with heat and mass transfer and the existence of heavy phase layer. The thickness of ‘the initial continuous frost layer’ was measured and it was disclosed that the initial frost layer thickness is 1.7–3.0 times that of the height of the frozen water drop diameter. This value may be possibly used as initial frost layer thickness in heat and mass transfer-based frost layer growth prediction models, at least for ordinary-low temperature conditions.
IoT-Enabled Campus Prosumer Microgrid Energy Management, Architecture, Storage Technologies, and Simulation Tools: A Comprehensive Study
Authors: Ali Amad , Muqeet Hafiz Abdul , Khan Tahir , Hussain Asif , Waseem Muhammad , Niazi Kamran Ali Khan
Published: February 2023

Energy is very important in daily life. The smart power system provides an energy management system using various techniques. Among other load types, campus microgrids are very important, and they consume large amounts of energy. Energy management systems in campus prosumer microgrids have been addressed in different works. A comprehensive study of previous works has not reviewed the architecture, tools, and energy storage systems of campus microgrids. In this paper, a survey of campus prosumer microgrids is presented considering their energy management schemes, optimization techniques, architectures, storage types, and design tools. The survey is comprised of one decade of past works for a true analysis. In the optimization techniques, deterministic and metaheuristic methods are reviewed considering their pros and cons. Smart grids are being installed in different campuses all over the world, and these are considered the best alternatives to conventional power systems. However, efficient energy management techniques and tools are required to make these grids more economical and stable.
Investigation of the Vibration Transmission Characteristics of the Aero-Engine Casing System by Rotating Force Exciter
Authors: Zhao Jingming , Hao Xiaolong , Zhang Kai , Li Yuanyuan , Zhang Guanghui
Published: February 2023

This work aims to study the dynamic characteristics of an entire aero-engine casing by experiments using a new type of rotating exciter. New vibration sensor layout rules are proposed according to experimental results and vibration transmission characteristics. The vibration response of the aero-engine casing is carried out, and the vibration response of different casing measuring points is also studied. The finite element model of the engine casing’s structure is established to obtain the natural frequency of the whole aero-engine casing, which agrees well with the experimental measurement. We find that the vibration acceleration transmission value of the radial measuring point of bearing No. 1, but not the fan sensor, is more suitable for detecting the running state of the fan rotor. In addition, the sensor in the intermediate casing can detect the vibration of the high-pressure rotor. Bolt loosening of the flange has little effect on the vibration transmission characteristics of the casing. This work aims to provide experimental data of whole aero-engine vibration characteristics with a new rotating exciter for the vibration test, which can help optimize the location of the vibration transducer for the engine and the assembly technology design for the whole engine structure.
Helichrysum italicum: From Extraction, Distillation, and Encapsulation Techniques to Beneficial Health Effects
Authors: Furlan Veronika , Bren Urban
Published: February 2023

Helichrysum italicum (family Asteraceae), due to its various beneficial health effects, represents an important plant in the traditional medicine of Mediterranean countries. Currently, there is a renewed interest in this medicinal plant, especially in investigations involving the isolation and identification of its bioactive compounds from extracts and essential oils, as well as in experimental validation of their pharmacological activities. In this paper, we review the current knowledge on the beneficial health effects of Helichrysum italicum extracts, essential oils, and their major bioactive polyphenolic compounds, ranging from antioxidative, anti-inflammatory, and anticarcinogenic activities to their antiviral, antimicrobial, insecticidal, and antiparasitic effects. This review also provides an overview of the most promising extraction and distillation techniques for obtaining high-quality extracts and essential oils from Helichrysum italicum, as well as methods for determining their antioxidative, antimicrobial, anti-inflammatory, and anticarcinogenic activities. Finally, new ideas for in silico studies of molecular mechanisms of bioactive polyphenols from Helichrysum italicum, together with novel suggestions for their improved bioavailability through diverse encapsulation techniques, are introduced.
Volatilomics Analysis of Jasmine Tea during Multiple Rounds of Scenting Processes
Authors: Zhang Cheng , Zhou Chengzhe , Tian Caiyun , Xu Kai , Lai Zhongxiong , Lin Yuling , Guo Yuqiong
Published: February 2023

Jasmine tea is reprocessed from finished tea by absorbing the floral aroma of jasmine (Jasminum sambac (L.) Aiton); this process is commonly known as “scenting”. Making high-quality jasmine tea with a refreshing aroma requires repeated scenting. To date, the detailed volatile organic compounds (VOCs) and the formation of a refreshing aroma as the number of scenting processes increases are largely unknown and therefore need further study. To this end, integrated sensory evaluation, widely targeted volatilomics analysis, multivariate statistical analyses, and odor activity value (OAV) analysis were performed. The results showed that the aroma freshness, concentration, purity, and persistence of jasmine tea gradually intensifies as the number of scenting processes increases, and the last round of scenting process without drying plays a significant role in improving the refreshing aroma. A total of 887 VOCs was detected in jasmine tea samples, and their types and contents increased with the number of scenting processes. In addition, eight VOCs, including ethyl (methylthio)acetate, (Z)-3-hexen-1-ol acetate, (E)-2-hexenal, 2-nonenal, (Z)-3-hexen-1-ol, (6Z)-nonen-1-ol, β-ionone, and benzyl acetate, were identified as key odorants responsible for the refreshing aroma of jasmine tea. This detailed information can expand our understanding of the formation of a refreshing aroma of jasmine tea.
The Use of Ozone Technology to Control Microorganism Growth, Enhance Food Safety and Extend Shelf Life: A Promising Food Decontamination Technology
Authors: Xue Wenya , Macleod Joshua , Blaxland James
Published: February 2023

The need for microorganism control in the food industry has promoted research in food processing technologies. Ozone is considered to be a promising food preserving technique and has gained great interest due to its strong oxidative properties and significant antimicrobial efficiency, and because its decomposition leaves no residues in foods. In this ozone technology review, the properties and the oxidation potential of ozone, and the intrinsic and extrinsic factors that affect the microorganism inactivation efficiency of both gaseous and aqueous ozone, are explained, as well as the mechanisms of ozone inactivation of foodborne pathogenic bacteria, fungi, mould, and biofilms. This review focuses on the latest scientific studies on the effects of ozone in controlling microorganism growth, maintaining food appearance and sensorial organoleptic qualities, assuring nutrient contents, enhancing the quality of food, and extending food shelf life, e.g., vegetables, fruits, meat, and grain products. The multifunctionality effects of ozone in food processing, in both gaseous and aqueous form, have promoted its use in the food industries to meet the increased consumer preference for a healthy diet and ready-to-eat products, although ozone may present undesirable effects on physicochemical characteristics on certain food products at high concentrations. The combined uses of ozone and other techniques (hurdle technology) have shown a promotive future in food processing. It can be concluded from this review that the application of ozone technology upon food requires increased research; specifically, the use of treatment conditions such as concentration and humidity for food and surface decontamination.
Measurement of Prosocial Tendencies: Meta-Analysis of the Generalization of the Reliability of the Instrument
Authors: Reig-Aleixandre Natalia , Esparza-Reig Javier , Martí-Vilar Manuel , Merino-Soto César , Livia José
Published: February 2023

The Prosocial Tendencies Measure (PTM) and its revised version (PTM-R) are used internationally to measure prosocial behaviors in different life situations. To obtain accumulated evidence of the report and the reliability of its scores, a meta-analysis of the reliability of internal consistency was performed. The databases of Web of Science (WoS) and Scopus were reviewed and all the studies that applied it from 2002 to 2021 were selected. Results: Only 47.9% of the studies presented the index of reliability of PTM and PTM-R. The meta-analytic results of the reliability report of the subscales that the PTM and the PTM-R have in common were: Public 0.78 (95% CI: 0.76–0.80), Anonymous 0.80 (95% CI: 0.79–0.82), Dire 0.74 (95% CI: 0.71–0.76), and Compliant 0.71 (95% CI: 0.72–0.78). Each one of them presents high levels of heterogeneity derived from the gender of the participants (percentage of women), the continent of the population, the validation design, the incentive to participate, and the form of application. It is concluded that both versions present acceptable reliabilities to measure prosocial behavior in different groups and situations, as adolescents and young people, but their clinical use is discouraged.
Green Finance and Technological Innovation in Heavily Polluting Enterprises: Evidence from China
Authors: Wang Bingwen , Wang Chen
Published: February 2023

There is an urgent need for countries worldwide to promote the green transformation of their economies and reduce environmental pollution. Based on China’s Green Credit Guidelines policy in 2012 and the data of Chinese listed companies from 2007 to 2021, we conducted an empirical test using the difference-in-differences method. The results showed that green finance policies inhibit technological innovation in heavily polluting enterprises, and the stronger the enterprise’s operating capacity, the weaker this inhibiting effect. The study also shows that bank loan, loan term, corporate management motivation, and business confidence have intermediation effects. Therefore, countries should improve green financial policies and promote technological innovation in heavily polluting enterprises in order to reduce environmental pollution and promote green growth.
ERβ1 Sensitizes and ERβ2 Desensitizes ERα-Positive Breast Cancer Cells to the Inhibitory Effects of Tamoxifen, Fulvestrant and Their Combination with All-Trans Retinoic Acid
Authors: Meligova Aggeliki K. , Siakouli Dimitra , Stasinopoulou Sotiria , Xenopoulou Despoina S. , Zoumpouli Maria , Ganou Vassiliki , Gkotsi Eleni-Fani , Chatziioannou Aristotelis , Papadodima Olga , Pilalis Eleftherios , Alexis Michael N. , Mitsiou Dimitra J.
Published: February 2023

Adjuvant endocrine therapy (AET) is the treatment of choice for early-stage estrogen receptor alpha (ERα)-positive breast cancer (BC). However, almost 40% of tamoxifen-treated cases display no response or a partial response to AET, thus increasing the need for new treatment options and strong predictors of the therapeutic response of patients at high risk of relapse. In addition to ERα, BC research has focused on ERβ1 and ERβ2 (isoforms of ERβ), the second ER isotype. At present, the impact of ERβ isoforms on ERα-positive BC prognosis and treatment remains elusive. In the present study, we established clones of MCF7 cells constitutively expressing human ERβ1 or ERβ2 and investigated their role in the response of MCF7 cells to antiestrogens [4-hydroxytamoxifen (OHΤ) and fulvestrant (ICI182,780)] and retinoids [all-trans retinoic acid (ATRA)]. We show that, compared to MCF7 cells, MCF7-ERβ1 and MCF7-ERβ2 cells were sensitized and desensitized, respectively, to the antiproliferative effect of the antiestrogens, ATRA and their combination and to the cytocidal effect of the combination of OHT and ATRA. Analysis of the global transcriptional changes upon OHT–ATRA combinatorial treatment revealed uniquely regulated genes associated with anticancer effects in MCF7-ERβ1 cells and cancer-promoting effects in MCF7-ERβ2 cells. Our data are favorable to ERβ1 being a marker of responsiveness and ERβ2 being a marker of resistance of MCF7 cells to antiestrogens alone and in combination with ATRA.
Alzheimer’s Disease: An Updated Overview of Its Genetics
Authors: Andrade-Guerrero Jesús , Santiago-Balmaseda Alberto , Jeronimo-Aguilar Paola , Vargas-Rodríguez Isaac , Cadena-Suárez Ana Ruth , Sánchez-Garibay Carlos , Pozo-Molina Glustein , Méndez-Catalá Claudia Fabiola , Cardenas-Aguayo Maria-del-Carmen , Diaz-Cintra Sofía , Pacheco-Herrero Mar , Luna-Muñoz José , Soto-Rojas Luis O.
Published: February 2023

Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1–5% of the total number of cases. It is categorized as early onset (EOAD; <65 years of age) and presents genetic mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), or the Amyloid precursor protein (APP). Sporadic AD represents 95% of the cases and is categorized as late-onset (LOAD), occurring in patients older than 65 years of age. Several risk factors have been identified in sporadic AD; aging is the main one. Nonetheless, multiple genes have been associated with the different neuropathological events involved in LOAD, such as the pathological processing of Amyloid beta (Aβ) peptide and Tau protein, as well as synaptic and mitochondrial dysfunctions, neurovascular alterations, oxidative stress, and neuroinflammation, among others. Interestingly, using genome-wide association study (GWAS) technology, many polymorphisms associated with LOAD have been identified. This review aims to analyze the new genetic findings that are closely related to the pathophysiology of AD. Likewise, it analyzes the multiple mutations identified to date through GWAS that are associated with a high or low risk of developing this neurodegeneration. Understanding genetic variability will allow for the identification of early biomarkers and opportune therapeutic targets for AD.
First X-ray Crystal Structure Characterization, Computational Studies, and Improved Synthetic Route to the Bioactive 5-Arylimino-1,3,4-thiadiazole Derivatives
Authors: Moussa Ziad , Paz Alejandro Perez , Judeh Zaher M. A. , Alzamly Ahmed , Saadeh Haythem A. , Asghar Basim H. , Alsaedi Sara , Masoud Bayan , Almeqbaali Salama , Estwani Saeda , Aljaberi Amna , Al-Rooqi Munirah M. , Ahmed Saleh A.
Published: February 2023

N-arylcyanothioformamides are useful coupling components for building key chemical intermediates and biologically active molecules in an expedited and efficient manner. Similarly, substituted (Z)-2-oxo-N-phenylpropanehydrazonoyl chlorides have been utilized in numerous one-step heteroannulation reactions to assemble the structural core of several different types of heterocyclic compounds. Herein, we demonstrate the effectiveness of the reaction of N-arylcyanothioformamides with various substituted (Z)-2-oxo-N-phenylpropanehydrazonoyl chlorides to produce, stereoselectively and regioselectively, a range of 5-arylimino-1,3,4-thiadiazole derivatives decorated with a multitude of functional groups on both aromatic rings. The synthetic methodology features mild room-temperature conditions, large substrate scope, wide array of functional groups on both reactants, and good to high reaction yields. The products were isolated by gravity filtration in all cases and structures were confirmed by multinuclear NMR spectroscopy and high accuracy mass spectral analysis. Proof of molecular structure of the isolated 5-arylimino-1,3,4-thiadiazole regioisomer was obtained for the first time by single-crystal X-ray diffraction analysis. Crystal-structure determination was carried out on (Z)-1-(5-((3-fluorophenyl)imino)-4-(4-iodophenyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)ethan-1-one and (Z)-1-(4-phenyl-5-(p-tolylimino)-4,5-dihydro-1,3,4-thiadiazol-2-yl)ethan-1-one. Similarly, the tautomeric structures of the N-arylcyanothioformamides and (Z)-geometries of the 2-oxo-N-phenylpropanehydrazonoyl chloride coupling partners were proven by X-ray diffraction studies. As representative examples, crystal-structure determination was carried out on (4-ethoxyphenyl)carbamothioyl cyanide and (Z)-N-(2,3-difluorophenyl)-2-oxopropanehydrazonoyl chloride. Density functional theory calculations at the B3LYP-D4/def2-TZVP level were carried out to rationalize the observed experimental findings.
N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling
Authors: Sakai Mai , Yu Zhiqian , Taniguchi Masayuki , Picotin Rosanne , Oyama Nanami , Stellwagen David , Ono Chiaki , Kikuchi Yoshie , Matsui Ko , Nakanishi Miharu , Yoshii Hatsumi , Furuyashiki Tomoyuki , Abe Takaaki , Tomita Hiroaki
Published: February 2023

N-acetylcysteine (NAC) is an antioxidant that prevents tumor necrosis factor (TNF)-α-induced cell death, but it also acts as a pro-oxidant, promoting reactive oxygen species independent apoptosis. Although there is plausible preclinical evidence for the use of NAC in the treatment of psychiatric disorders, deleterious side effects are still of concern. Microglia, key innate immune cells in the brain, play an important role in inflammation in psychiatric disorders. This study aimed to investigate the beneficial and deleterious effects of NAC on microglia and stress-induced behavior abnormalities in mice, and its association with microglial TNF-α and nitric oxide (NO) production. The microglial cell line MG6 was stimulated by Escherichia coli lipopolysaccharide (LPS) using NAC at varying concentrations for 24 h. NAC inhibited LPS-induced TNF-α and NO synthesis, whereas high concentrations (≥30 mM) caused MG6 mortality. Intraperitoneal injections of NAC did not ameliorate stress-induced behavioral abnormalities in mice, but high-doses induced microglial mortality. Furthermore, NAC-induced mortality was alleviated in microglial TNF-α-deficient mice and human primary M2 microglia. Our findings provide ample evidence for the use of NAC as a modulating agent of inflammation in the brain. The risk of side effects from NAC on TNF-α remains unclear and merits further mechanistic investigations.
Tardive Syndrome Is a Mysterious Phenomenon with Different Clinical Manifestations—Review
Authors: Badarny Samih , Nassar Rima , Badarny Yazid
Published: February 2023

Tardive syndrome (TS) refers to persistent hyperkinetic, hypokinetic, and sensory complaints appearing after chronic neuroleptics and other dopamine receptor-blocking agents (DRBAs). It is defined as involuntary movements, often rhythmic, choreiform, or athetoid, involving the tongue, face, extremities, and sensory urges such as akathisia and lasts for a few weeks. TS develops in association with neuroleptic medication usage for a few months at least. There is usually a delay between the initiation of the causative drug and the onset of abnormal movements. However, it was soon noted that TS can also develop early, even days or weeks after DRBAs begin. However, the longer the exposure, the greater the risk of developing TS. Tardive dyskinesia, dystonia, akathisia, tremor, and parkinsonism are frequent phenomenologies of this syndrome.