bluuebunny/crossref_metadata_2025 huggingface dataset:
RELATIONSHIP BETWEEN KNOWLEDGE MANAGEMENT AND INNOVATIVE PERFORMANCE IN NanoMiPyMes OF THE TEXTILE SECTOR OF THE MUNICIPALITY OF ASUNCIÓN IXTALTEPEC, OAXACA
Authors: CRUZ-CABRERA BLASA CELERINA , JIMÉNEZ-VELASCO GABRIELA , RUÍZ-MARTÍNEZ ALFREDO , GUENDULAY-LEÓN KAREN ALEJANDRA
Published: August 2022

Knowledge Management (KM) is considered as the administration of knowledge, through the process of transferring tacit knowledge to the explicit, through the model called Socialization, Externalization, Combination and Internalization (SECI), while Innovative Performance (IP) is the result of the effectiveness in the production processes and the efficiency of new and/or improved products. The objective of this work was to determine the present relationship between Knowledge Management and Innovative Performance within the textile sector NanoMiPyMes, belonging to the municipality of Asunción Ixtaltepec, Oaxaca. The first phase was the design, validation, and application of the measurement instrument (survey) with a Lickert-type scale. Quantitative data analysis was performed using the SPSS® ver. 24.0 statistical program. We worked with a sample of 31 questionnaires applied to artisans of the economic units (NanoMiPyMes) of the textile sector, using the nonprobabilistic snowball method; the results indicated that there is a positive relationship between both variables. In conclusion, we can say that there is a positive influence on innovative performance through knowledge management in the textile sector NanoMiPyMes of Asunción Ixtaltepec, Oaxaca.
A STUDY ON PHYTOCHEMICAL SCREENING ANTIOXIDENT AND IN VITRO-ANTICANCER ACTIVITY OF Aplotaxis auriculata ROOTS EXTRACT
Authors: MANIKANDAN R. , RAVICHANDRAN M. , ANBURAJ G.
Published: August 2022

The current examination was done to depict the bioactive compound constituents in plant concentrate of Aplotaxis auriculate using UV range - 210-290, FTIR, absorbance was recorded in the zone of some place in the scope of 4000 and 400 cmˉ¹. The zenith 3370 (Alcoholic and Phenolic social affairs), 2947 (Alkanes), 1656 (Alkene), 1453 (Alkane) and 668 cmˉ¹ (Aromatic) exhibits the individual get-togethers, and in vitro cell fortification against illness activities of Aplotaxis auriculata methanol remove. Cell support activity was done through DPPH, Hydrogen peroxide scrounging activity and diminishing power look at. Cell support and unfriendly to sickness practices were seen that A. auriculata extended with growing obsession. The human chest torment cell line (Michigan Cancer Foundation-7 (MCF 7)) was gotten from National Center for Cell Science (NCCS), Pune and made in Eagles Minimum Essential Medium (EMEM) containing 10% fetal dairy creatures like serum (FBS). The cells were kept up in Minimal Essential Media (MEM) improved with 10% Fetal dairy animals like serum (FBS), penicillin (100 U/ml), and streptomycin (100 μg/ml) in a humidified atmosphere of 5% CO2 at 37°C. Support social requesting were passaged following a long time after week, and the way of life medium was changed on different occasions reliably. Over piece of all authentic canny meds are standard things that perceive a principal occupation in calm improvement in medication endeavors.
PHARMA REGULATION IN BRAZIL: A REGULATORY VIEW
Authors: THOYAJAKSHA V. , DEEKSHA K. S. , BALAMURALIDHARA V. , GOWRAV M. P. , THANUSH D.
Published: August 2022

Brazil, which has the most people of any country in South America, just overtook India to become the country with the second-largest pharmaceutical sector in the entire globe. The National Health Surveillance Agency of Brazil, also known as Agência Nacional de Vigilancia Sanitária (ANVISA), was established in 1999 with the primary goal of protecting and enhancing Brazilian public health surveillance of pharmaceutical products and services. Its acronym, ANVISA, is an acronym for the name of the agency. The Brazilian Health Surveillance Agency, also known as ANVISA and housed inside the Ministry of Health, is responsible for supplying the pharmaceutical sectors with the necessary regulatory procedures and documentation. ANVISA's mission is to achieve public legitimacy as a key component of the Brazilian Unified Health System by developing a health monitoring organisation that possesses the agility, modernity, and transparency necessary to act as a national and international benchmark. This goal will be accomplished by developing a health monitoring organisation that possesses these characteristics. ANVISA is in charge of managing the registration and licencing processes for pharmaceutical laboratories and other types of businesses involved in the production of pharmaceuticals. The purpose of this research is to acquire an in-depth comprehension of the requirements imposed by the Ministry of Health of Brazil on pharmaceuticals, biological products, medical devices, and clinical trials.
ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS IN KORE DISTRICT, SOUTHEASTERN ETHIOPIA
Authors: NEGA SELAMAWIT , GIRMA ZERIHUN
Published: August 2022

Across the world throughout the age, plants have been an important source of both defensive and curative traditional medicine preparation for human and livestock diseases. However, in the Kore district no ethnobotanical exploration had previously been conducted. Therefore, the present study was conducted to identify plant species that are used as traditional medicines for the treatment of human and livestock diseases and to determine and document traditional medicinal plant parts used, their mode of preparation, dosage, route of administration of remedies and associated traditional knowledge in the study area. The result of the survey revealed that a total of 97 medicinal plants belonging to 91 genera and 53 families were identified. From the total plant species (64.9%) were collected from wild vegetation and (15.4%) are from home gardens and the rest of 12.4% are from roadsides, fences, farmlands and villages. In the study area (62.9%) species were recorded for the treatment of human health problems,(20.6%) for livestock and(16.5%) for the treatment of both human and livestock. Leaves were the most frequently used part in preparing herbal remedies. Crushing and oral route of administration were commonly used method of herbal medicine preparation and administration respectively. The most common condition of preparation was fresh form of preparation. Preference ranking analysis showed that Olea europaea ranked first for the most effective medicinal plant to cure wound. Pair wise comparison of medicinal plant shows that Lepidium sativum is the most preferred in treating stomachache. Informant consensus agreement for Febrile illness, Headache, Fever and Dizziness have high Informant consensus factor (0.85). The analysis result of FL shows that Allium sativum scored the highest FL (80%).
Impact of COVID-19 Crisis on Healthcare Sector in Bangladesh and Possible Solutions
Authors: Sorwar Golam
Published: August 2022

Like most other countries in the world, the recent COVID-19 outbreak has severely impacted the healthcare sectors in Bangladesh. Despite a very late response to the COVID-19 outbreak, many governments and non-government initiatives have been launched to deal with the crisis in Bangladesh. However, it is evidenced that there is a severe dearth of health personnel, ICU beds, ventilators, PPE, and other required medical equipment for health professionals. The inadequate and ill-timed response from the government has resulted in an increased rate of infection and deaths. Moreover, Non-COVID-19 patients suffer from accessing their regular treatments, primarily due to the lack of safety provided to the health professionals. Therefore, rapid and proactive measurements, digital interventions at a large scale (e.g., use of mHealth and artificial intelligence), decentralization (e.g., equal support and availability of facilities in both rural and urban areas), healthcare budget, multi-party coordination, boosting support for private startups, and increasing testing and treating facilities are highly recommended as possible solutions. Keywords: COVID-19, Pandemic, Healthcare, Bangladesh.
Interactive Whiteboard Use for Developing Phonological Awareness in SEN Students
Authors: Calota Ruxandra , Vasile Marinela
Published: August 2022

This paper considers the impact of using interactive whiteboards to promote phonological awareness among SEN students through whole-class online activities. Data collected suggests the tactile features of IWB, as well as the added game elements increase the students’ learning motivation and the task completion rate.The results indicate this specific type of technology has the potential to facilitate a better understanding of word structure in students with developmental / intellectual disabilities and it appears to motivate and engage them in learning more than traditional literacy activities.
Educating children with mild intellectual disability in the online environment
Authors: Baciu (Pungilă) Damaris
Published: August 2022

The article contains a summary of the main problems encountered during distance education. The main challenges faced by teachers in special education, but also by their families are presented. The shift of special education to the online environment due to the covid-19 pandemic has led to the use of different methods and resources. One of the ways in which the adaptation to new methods and resources has been made is presented at the end of the article through a comparative analysis. It presents the traditional way of conducting a therapy session with children with mild mental disabilities and how it was conducted online.
The relationship between the time spent in family environment and preschool language development
Authors: Dumitrache Ana-Maria
Published: August 2022

The goal of this study was to identify and to assess the characteristic aspects regarding the preschool language and communication development depending on the quality and quantity of the allocated parental time, as well as on the characteristics of the family environment. The sample included 155 children aged 36 – 71 months old (M = 52.61, SD = 10.40) and their parents. The results of present research suggest that an increased level of parental involvement in structured activities predicts an increased level of language development, an increased level of time spent in familial environment predicts an increased level of language development, at the same time, the relationship between parental involvement in family learning activities is moderated by the chronological age of preschool children in the sense that at an early age, the effect of parental involvement in structured activities and time spent by parents with children on language development and the parents involvement in structured activities and the time spent by parents with children on extraverbal features is stronger compared to that related to older ages. Findings highlight the unique contributions of parental implication and the quality time on preschool language development.
Neue Geschäftsfelder entwickeln
Authors: Eisenreich Thomas
Published: August 2022

Das Aufspüren und die Entwicklung neuer Angebote und innovativer Geschäftsfelder erfordert einen Blick, der über den Tellerrand des sozialrechtlichen Dreiecks hinausgeht. Verlangt ist ein genauer Blick auf die Bedürfnisse der Nutzer und auf sein Umfeld.
Steuerung erfordert Fachlichkeit
Authors: Gellert-Beckmann Stefanie
Published: August 2022

Angesichts der gesetzlichen vorgeschriebenen Qualität und Wirksamkeit der Leistungserbringung brauchen soziale Organisationen eine qualifizierte fachliche Führung als Gelingensfaktor für die Umsetzung der Eingliederungshilfereform.
Beratung als Service
Authors: Metz Markus
Published: August 2022

Ein neue konzipiertes Beratungszentrum für Menschen mit Behinderung, Angehörige, Leitungs- und Fachpersonal soll in der Region Stuttgart eine zukunftsorientierte Neuausrichtung der Sozialen Dienste ermöglichen. Die Organisationszentrierung soll schrittweise durch ein kundenorientiertes pädagogisches Arbeiten abgelöst werden.
Auftrag: Mehrwert stiften
Authors: Neumann Dominique
Published: August 2022

Digitalisierung darf kein Selbstzweck sein, sondern muss für die Organisation, die Mitarbeitende und die Kunden neue Chancen bieten. Erfolgreiche Projekte der Digitalisierung hängen somit entscheidend auch von kluger Führung ab. Dominique Neumann von der rosenbaum nagy unternehmensberatung GmbH erläutert, wie Organisationen die Weichen stellen müssen, um den erforderlichen Transformationsprozess erfolgreich gestalten zu können.
Fachkräfte frühzeitig abholen
Authors: Magdanz Helga
Published: August 2022

Viele Schulen erwarten von ihren Schüler:innen einen zeitlich begrenzten Einsatz in der Arbeitswelt. Soziale Organisationen und Unternehmen können diese Möglichkeit zur Information über benachteiligte Menschen nutzen und gleichzeitig Bindungen zu möglichen künftigen Mitarbeitenden aufbauen. Helga Magdanz vom Meppener Komplexträger Vitus zeigt, worauf es bei der Konzeption, Organisation, beim Personaleinsatz und bei der Finanzierung solcher Aktionen ankommt.
Möglichkeitsräume eröffnen
Authors: Herriger Norbert
Published: August 2022

Wirksames Empowerment benötigt eine strukturelle Verankerung in sozialwirtschaftlichen Unternehmen. Eine Möglichkeit sind »Empowerment-Zirkel«, beispielsweise funktionsübergreifend zusammengesetzte Arbeitsgruppen.
InterkulturelleKompetenzen fördern
Authors: Sürgit Hasan
Published: August 2022

Der Landesverband des Deutschen Roten Kreuzes in Westfalen-Lippe hat differenzierte Diversitäts- und Antidiskriminierungskonzepte entwickelt und sich den Herausforderungen bei ihrer verbandsinternen Umsetzung gestellt. Vorstandsvorsitzender Dr. Hasan Sürgit fasst die Beweggründe für das Vorgehen seiner Organisation zusammen und gibt einen kritischen Ausblick.
Einvernehmensorientiertes Vorgehen in der Sachverständigentätigkeit nach dem FamFG
Authors: Balloff Rainer
Published: August 2022

Nach der gesetzlichen Vorgabe des § 163 Abs. 2 FamFG sollen psychologische Sachverständige in Familienrechtsverfahren immer dann auf Einvernehmen hinwirken, wenn dies Bestandteil des richterlichen Beschlusses ist und der/die Sachverständige fachlich davon überzeugt ist, dass ein solches Einvernehmen möglich ist. In diesem Beitrag werden die Rahmenbedingungen und fachlichen Anforderungen an ein solches Vorgehen psychologischer Sachverständiger im familiengerichtlichen Verfahren genauer spezifiziert sowie diesbezügliche Probleme und Grenzen benannt. Daran anknüpfend werden konkrete Hinweise auf Optionen der Ausgestaltung des praktischen methodischen Vorgehens bei einer einvernehmensorientierten sachverständigen Begutachtung im Familienrecht gegeben.
Barriers to Adherence to Cancer Treatments Among Head and Neck Cancer Patients
Authors: Lynn Miller, PhD, RN, CMSRN Jennifer , Evers, DNP, APRN, AGACNP-BC, CCRN Julianne
Published: August 2022

Head and neck cancer patients often undergo a demanding treatment schedule requiring radiation and chemotherapy. Adherence to these treatment schedules is affected by several issues, including socioeconomic factors, characteristics of the disease and treatment plan, symptoms, and side effects. Oncology advanced practitioners (APs) work directly with patients with head and neck cancer (HNC) during active treatment, often screening for and managing side effects and providing referrals. Evidence-based interventions and innovative strategies for the oncology AP to improve HNC patients’ quality of life and treatment adherence include frequent distress screening, AP-led educational interventions and symptom management clinics, and incorporating technology to allow for close contact with patients during treatment.
LA CUALIDAD DEVELADORA DE LA IMAGINACIÓN: EN BUSCA DE LOS TESOROS DE LOS COLORES
Authors: Crespo Ana
Published: August 2022

Resumen: Abordamos el significado simbólico del color en Ibn ʻArabī, planteando la relación entre color, imaginación y Luz Muhammadí, y la importancia de los diseños cromáticos, forma, ritmo y armonía, en la recomposición de la Luz Muhammadí y en la culminación del viaje interior.Se revisan conceptos akbaríes desde la óptica de las artes plásticas y del creador actual. Metodología creadora, percepción o intención creadora están en la base de la sutil cosmología del maestro.Junto a una presentación general de la casuística del color, ahondamos en un recorrido en diferentes niveles simbólicos de ciertos colores en un viaje imaginal de develamiento a través de diferentes esferas cromáticas y universos simbólicos de estos colores, cuyas variadas cualidades se activan en contacto armónico con otros colores.Profundizamos en la cualidad simbólica del color rojo y en la función esencial de la himma, voluntad espiritual creadora, en este viaje interior de develamiento, en el que Ibn ʻArabī alienta a avanzar sin detenerse en el embeleso de los estados, hacia la estación radiante del Azufre Rojo, el ser convertido en pura creatividad transformadora.

Abstract: We discuss the symbolic meaning of colour in Ibn ʻArabī's work, considering the relationship between colour, imagination and Muhammadī Light, and the importance of chromatic designs, form, rhythm and harmony in the recomposition of the Muhammadī Light and in the culmination of the inner journey.Akbarian concepts are reviewed from the point of view of the visual arts and the present-day creator. Creative methodology, perception or creative intention are at the basis of the master's subtle cosmology.In addition to a general presentation of the casuistry of colour, we delve into a journey through the different symbolic levels o fcertain colours in an imaginary journey of unveiling through different chromatic spheres and symbolic universes of these colours, whose varied qualities are activated in harmonious contact with other colours.We delve into the symbolic quality of the colour red and the essential function of the himma, the creative spiritual will, in this inner journey of unveiling, in which Ibn ʻArabī encourages to move forward without stopping in the rapture of states, towards the radiant station of Red Sulphur, the being turned into pure transformative creativity.
Far-field calculation of an arbitrarily oriented electric dipole in horizontal layered confined space
Authors: Zhou Li-Li , Hu Xin-Yue , Mu Zhong-Lin , Zhang Rui , Zheng Yue ,   School of Electronic Information and Artificial Intelligence, Shaanxi University of Science and Technology, Xi’an 710021, China,   School of Aerospace Engineering, Air Force Engineering University, Xi’an 710038, China
Published: August 2022

The far-field calculation of arbitrarily oriented electric dipole in a stratified confined space is of great significance in analyzing electromagnetic properties in the lightning return stroke, submarine communication, over-the-horizon ground-wave radar, etc. Based on the mirror image method and the far-field approximation of an electric dipole in free space, a three-layer horizontal confined space model with an arbitrarily oriented dipole is established in this work. Through novel vector operations, the expression of the far field generated by an arbitrarily oriented electric dipole in the confined space model is derived, where the direct wave from the source point to the observation point and the waves reflected by the upper boundary and the lower boundary are all comprehensively considered. On this basis, the radiation characteristics of the electric dipole with frequencies of 100 kHz, 6 MHz and 10 MHz at different positions in the Earth-ionosphere waveguide are compared and analyzed, which are taken for example. Three different orientations of electric dipoles,i.e. vertical direction, horizontal direction, and 45º tilt are taken into account and the corresponding radiation patterns are presented. The results show that the radiation characteristics of electric dipoles in the Earth-ionosphere waveguide will change greatly with their frequencies, orientations and positions. For the electric dipole source at the same location, the higher the frequency, the more the number of radiation lobes is. In addition, when the source frequency keeps unchanged, the farther the dipole source is from the bottom boundary, the more the radiated lobes are. The proposed expression can conveniently and accurately consider the direct wave of a dipole source and its primary reflection from the upper interface and the lower interface in a confined space, and can also be further extended to solving the contribution of multiple reflections from the interfaces.
The COVID-19 infodemic in Brazil: trends in Google search data
Authors: Harb Maria da Penha , Veiga e Silva Lena , Vijaykumar Nandamudi , Silva da Silva Marcelino , Lisboa Frances Carlos Renato
Published: August 2022

Background

Since the beginning of the new coronavirus pandemic, there has been much information about the disease and the virus has been in the spotlight, shared and commented upon on the Internet. However, much of this information is infodemics and can interfere with the advancement of the disease and that way that populations act. Thus, Brazil is a country that requires attention, as despite the fact that in almost two years of pandemic it has shown a devastating numbers of deaths and number of cases, and generates false, distorted and malicious news about the pandemic. This work intends to understand the attitudes of the Brazilian population using infodemic queries from the Google Trends search tool and social and income variables.

Methods

Data from infodemic research carried out on Google Trends, between January 1, 2020 and June 30, 2021, with socioeconomic data, such as income and education, were unified in a single database: standardization and exploratory and multivalued techniques based on grouping were used in the study.

Results

In the analysis of the search trend of infodemic terms, it is clear that the categories of Prevention and Beliefs should stand out in Brazil, where there is a diverse culture. It is followed by the COVID-19 Treatment category, with treatments that were not those recommended by the authorities. Income transfer programs and information on socioeconomic variables did not have much impact on infodemic surveys, but it was observed that states where President Bolsonaro has more supporters had researched more infodemic information.

Conclusions

In a country as geographically large as Brazil, it is important that political authorities go to great lengths to disseminate reliable information and monitor the infodemic in the media and on the internet. It was concluded that the denial of the pandemic and the influence of political leaders influenced the search for infodemic information, contributing to a disorganization in the control of the disease and prevention measures.
Assessment of Level of Market Integration in Indian Cotton Markets
Authors: Mamatha Narayanaswamy , Shivakumar K. M. , Vidhyavathi A. , Murugananthi D.
Published: August 2022

The current study is aimed at using co-integration in assessing the level of market integration among selected cotton markets in India. Monthly cotton price data were collected for the period 2008-09 and 2016-17 from the AGMARKNET website. The advanced time series econometric tools like Augmented Dickey-Fuller (ADF) test, Johansen co-integration test and Granger Causality test were used to study market integration using E-Views software. The price series for cotton in selected markets were subjected to the consequences of unit root and were stationary at first difference. The long-run equilibrium relationship among the cotton markets indicated that these markets were integrated with each other. This implied that prices in Indian cotton markets tend together in response to changes in the demand and supply of cotton. Granger Causality test revealed that the Salem market was the lead cotton market because it influenced the prices of Kurnool and Warangal cotton markets.
Role of Iron Uptake Systems in Coordinating Iron Homeostasis in NaCl-resistant Mutant of the Cyanobacterium Nostoc muscorum
Authors: Bhargava Santosh , Katrolia Neelu , Choudhary Antim
Published: August 2022

Aims: To investigate the effect of NaCl stress on parent Nostoc muscorum and its spontaneously occurring mutant clone showing resistance to growth inhibitory action of NaCl in terms of various physiological parameters. We have further analyzed the role of iron uptake systems in providing a resistant phenotype.

Place and Duration of Study: Division of Microbiology, Department of Botany, Government Motilal Science College, Bhopal 462008 (M.P.) India. This work was carried out between August 2021 to May 2022.

Methodology: We have examined the various physiological parameters viz. growth, specific growth rate, photosynthetic O2 evolution, and nitrogenase activity as per the prescribed protocol. Further, DNA microarray analysis was carried out using the Agilent platform.

Results: NaCl stress adversely affected growth, photosynthetic O2 evolution, and nitrogenase activity of the wild-type Nostoc muscorum, while NaCl-resistant mutant remains unaffected under a given stress. Microarray data analysis identified 24 ORF related to the uptake of iron with fold regulation ≥2 in the mutant strain. These ORFs belonging to the ABC-type ferric iron transporter that plays a significant role in the iron acquisition were identified in the mutant strain.

Conclusion: The mechanism of iron homeostasis in the NaCl-resistant mutant has been explained. The results presented are essential to explain the regulatory role of the iron uptake system in stressed conditions.
Extrapyramidal Symptoms and Novel Antipsychotic Drugs
Authors: O. Nwokike M. , Ghasi S. I. , Ogbonna A. O. , Ezenwaeze M. N. , Ezinwa A. C.
Published: August 2022

One of the challenges of antipsychotic medication is the occurrence of Extrapyramidal Symptoms. These cannot be easily eliminated considering the pathophysiology of schizophrenia and the established mechanism of action of classical antipsychotics. The antipsychotics help improve symptoms of schizophrenia by binding to dopamine receptors in the central nervous system and blocking dopamine. This prevents the basal ganglia from getting enough dopamine. Many drugs used in the treatment of mental disorders such as the neuroleptics and antidepressants adversely affect extrapyramidal system function, resulting in symptoms such as tremors and muscle rigidity collectively known as extrapyramidal symptoms. Treatment generally involves lowering the dose or trying a different antipsychotic but drugs may also be used specifically to treat symptoms. This review examines the attempt to eliminate extrapyramidal symptoms by generations of antipsychotic medications and their comparative efficacy in the treatment of schizophrenia. A wide internet search was carried out using keywords and phrases that include; Antipsychotics, Typical Antipsychotics, Atypical Antipsychotics, Dopaminergic, Extrapyramidal symptoms, comparative efficacy of Antipsychotics and Adverse Effect of Antipsychotics. This will further reinforce knowledge and prescription patterns for antipsychotic medications.
Insertion of Tunneled Hemodialysis Catheters by Exchange over the Guidewire and De Novo Puncture
Authors: Shanshoury Eslam Adel Ramadan El , Sallam Emad Mohammad , Abo-Ryia Mohammed Hamdy , Kamhawy Adel Husseiny
Published: August 2022

Background: This study evaluated the safety and efficacy of insertion of tunneled hemodialysis catheters by de novo insertion technique and over the wire exchange technique

Methods: This prospective study included 50 patients with ERSD in need for tunneled hemodialysis catheters insertion. Patients were divided into 2 groups (the first group) 22 de novo insertion of tunneled dialysis catheters and (the second group) 28 over the wire exchange. Patients were subjected to history taking, thorough clinical examination, routine preoperative investigations, preoperative and postoperative X-ray on the neck and chest and Duplex scan of neck veins on both sides.

Results: In the de novo group, 11 patients were inserted by ultrasound guide and 11 patients were inserted by blind anatomical landmark technique in which the ultrasound guided technique showed lower rate of complications, while all over the wire group were inserted ultrasound guided. The primary patency was higher in the over the wire group(after 1 month=96%, after 3 months=89.2%, after 3 months=85.7%) than the de novo group(after 1m, 3m, 6m equals 86.3%,81.8%, 77.2% respectively) with non-significant P value 0.43, hematoma formation was higher in the de novo group with non-significant P value, 3 patients  (13.6%) had infected catheters in the de novo group while 4 (14.3%) patients were affected in over the wire group, with 4 (18.2%) cases were malfunctioning in the de novo group while 3 (10.7) malfunctioning catheters in over the wire group with statistically non-significant P value in these values.  There was significant difference between the 2 techniques in the operative time, for de novo insertion of tunneled dialysis catheters mean operative time was = 27.78 ± 5.71 minutes and in over the wire group the mean operative time was = 15.07 ± 1.98 minutes with statistically significant P value <0.001*.

Conclusions: By comparison between the two methods of tunneled dialysis catheters insertion in ESRD patients (de novo insertion and over the wire exchange technique), we found that over the wire exchange technique can safe time, effort, reduce the rate of operative complication especially hematoma formation and at the same time it showed higher patency rate in comparison to de novo insertion method.
Cytokines (IL-17, IL-23 and IL-33) in Adult Patients with Systemic Lupus Erythematosus in Trinidad and Tobago
Authors: Vaillant Angel Justiz , E. Akpaka Patrick
Published: August 2022

Systemic lupus erythematosus (SLE) is the most common autoimmune disease. It is characterized by the presence of hundreds of autoantibodies against many organs and tissues, including the presence of a large number of autoantibodies, which are specific to self-antigens mainly of nuclear origin such as Smith antigen, double-stranded DNA (dsDNA), anti-Sjögren’s syndrome-related antigen A and B (SSA/Ro and SSB/La, respectively) and ribonucleoproteins, which are the hallmarks of the disease. Type I and II interferons, interleukin-6 (IL-6), IL-1, tumor necrosis factor-alpha (TNF-α), and immunomodulatory cytokines such as IL-10 and TGF-β are essential players in SLE. Additionally, T-cell-derived cytokines such as IL-17, IL-21, and IL-2 are dysregulated in SLE. In this study among cohorts of 60 individuals attending the hospital clinics in Trinidad and Tobago, blood samples were analyzed and the levels of the essential cytokines were measured using SLE Disease Activity Index (SLEDAI) 2000 score. The results confirmed that serum IL-17 and IL-23 levels were positively correlated with the SLE Disease Activity Index (SLEDAI) 2000 score in these patients. These findings have diagnostic and therapeutic implications. However, more work must be done targeting other cytokines relevant to autoimmunity and SLE in particular. Interleulin-33 is not an SLE marker, as has been noted in other populations.
Quantifying Water Use Efficiency in Paddy Production for Different Regions of Thenpennaiyaru River Basin (TRB) of Tamil Nadu
Authors: Venkatesh M. , Vidhyavathi A. , Kumar D. Suresh , Raviraj A. , Duraisamy M. R.
Published: August 2022

Agriculture is the world's greatest user and consumer of water. Crop irrigation accounts for two-thirds of all world water withdrawals and 85 per cent of total global water consumption. Today we face major issues on water scarcity which is closely related to “water stress” or “water crisis” is the lack of fresh water resources to meet the standard water demand. Irrigated cropping faces some issues on, decreasing water supply owing to increasing extraction and fewer inflows, as well as increased competition from other users in this context the current study focused on the estimation of crop water use efficiency and irrigation efficiency in the different regions of Thenpennaiyaru river basin (TRB) of Tamil Nadu. As per the Central Water Commission’s Basin Report, Thenpennaiyar Basin is the second largest interstate flowing river basin among the 12 basins lying between pennar and Cauvery basins. The river is the main source for irrigating over 38,000 acres in Krishnagiri district; 6250 acres in Dharmapuri district; 17,980 acres in Tiruvannamalai district and 25000 acres in Villupuram district and majority of population depend on this river for agricultural and allied activities. So, this river basin was purposefully selected for the present study to access the efficiency in water usage with the sample size of (320). As per the result CWUE is better in the head region (12.34 quintals/ha/mm) due to consistent water supply, which is directly dependent on effective management practices, which ultimately have higher efficiency and higher yield. Irrigation efficiency is most similarly in all three regions. The CWUE is a better indicator when quantifying the efficiency of a crop production system because it directly reflects the amount of grain yield produced per amount of water used rather than per depth of water applied, which is the case with the IWUE.
Phytochemical Analysis and Anthelmintic Activity of Ethanolic Extracts of Gmelina arborea on the Bovine Parasite Onchocerca ochengi
Authors: Bertrand Mando Ndou , Raymond Bambe , Mathieu Djongra , Mang-Dobara Koga , Dieudonné Ndjonka
Published: August 2022

Aims: This study was aimed at analyzing the phytochemical constituents, evaluated the in vitro filaricidal activities of the ethanolic extracts of G. arborea on Onchocerca ochengi and carried out the acute and sub-acute toxicity on rats.

Place and Duration of Study: The work took place at the Laboratory of Applied Zoology of the Faculty of Science of the University of Ngaoundere between June 2020 and April 2021.

Methodology: Quantitative determination of total phenols, total flavonoids and tannins were performed by using standard titration curve of gallic acid and rutin. The adult male worms of O. ochengi were incubated in Roosevelt Park Memorial Institute (RPMI-1640) medium supplemented with antibiotics containing different concentrations of the plant extracts and ivermectin (positive control). The mortality of worms was evaluated using the MTT/formazan colourimetry test after 24 h and 48 h. Acute and sub-acute toxicity tests of G. arborea were evaluated on rats according to OECD 425 and 407 respectively.

Results: The quantitative phyto-constituents screening revealed that total phenols (873.33 ± 3.33 mg GAE/g) were the most quantified compound followed by tannins (229.33 ± 0.33 mg GAE/g) and total flavonoids (116 ± 1.01 mg RE/g) in the roots of the plant. 0.22 ± 0.02 mg/mL, 0.17 ± 0.00 mg/mL, 0.16 ± 0.01 and 0.11 ± 0.01 mg/mL were respectively the LC50 of hydroethanolic extracts of the leaves, barks, roots and ivermectin at 48 h. The acute and sub-acute toxicity test showed no toxicity in rats.

Conclusion: Looking at the result, the extracts of this plant may be used in novel drug discovery to fight against onchocerciasis.
Effect of Modified Vertical Rectus Belly Transposition vs Augmented Superior Rectus Transposition Plus Medial Rectus Recession for Chronic Sixth Nerve Palsy
Authors: Yao Jing , Jiang Chao , Wang Xiying , Xia Weiyi , Ling Ling , Zhu Wenqing , Wu Lianqun , Zhao Chen
Published: August 2022

Importance

Both vertical rectus belly transposition (VRBT) and superior rectus transposition (SRT) can be performed simultaneously with ipsilateral medial rectus recession (MRc) and have been shown to be effective for chronic sixth nerve palsy. However, it is unclear whether VRBT is superior to SRT in correcting esotropia.

Objective

To compare the effectiveness of modified VRBT plus MRc (mVRBT-MRc) vs augmented SRT plus MRc (aSRT-MRc) in Chinese patients with chronic sixth nerve palsy.

Design, Setting, and Participants

This parallel-design, double-masked, single-center, randomized clinical trial was conducted from January 15, 2018, to May 24, 2021. The follow-up visits were scheduled at 1 month and 6 months. Eligible Chinese participants with unilateral chronic sixth nerve palsy were randomly assigned to receive either mVRBT-MRc (VRBT group) or aSRT-MRc (SRT group).

Interventions

mVRBT-MRc or aSRT-MRc.

Main Outcomes and Measures

Change of horizontal deviation in primary position from baseline to 6 months.

Results

Of the total 25 eligible participants, the mean (SD) age was 45.4 (12.6) years, with 10 male participants (40%) and 15 female participants (60%). Thirteen participants (52%) were randomly assigned to the VRBT group, and 12 (48%) were randomly assigned to the SRT group. At baseline, the mean (SD) horizontal deviation was 65.7 (10.8) prism diopters (Δ) in the VRBT group and 60.5Δ(14.1Δ) in the SRT group. Similar amounts of MRc were performed in both groups. At 6 months, the horizontal deviation changed from baseline by 66.3Δ in the VRBT group and by 51.5Δ in the SRT group. The adjusted group difference was 10.9Δ (95% CI, 5.3Δ-16.6Δ), favoring the VRBT group (P = .001). Four times as many participants corrected more than 60Δ with mVRBT-MRc compared with aSRT-MRc. The group difference of the improvement of abduction limitation was −0.2 (95% CI, −0.8 to 0.5; P = .64). Although there was a higher proportion of undercorrection in the SRT group (difference, 45%; 95% CI, 16%-75%; P = .01), no differences were identified for other suboptimal outcomes between groups.

Conclusions and Relevance

Compared with aSRT-MRc, mVRBT-MRc showed better effect in correcting esotropia with no differences detected for other suboptimal outcomes. mVRBT-MRc may be a promising alternative surgical procedure for chronic sixth nerve palsy, particularly for large esotropia of more than 60Δ, if these results are confirmed in larger, diverse cohorts with longer follow-up.

Trial Registration

ChiCTR Identifier: ChiCTR-INR-17013705
Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells
Authors: Santi Maria Daniela , Zhang Morgan , Salvo Elizabeth , Asam Kesava , Viet Chi T. , Xie Tongxin , Amit Moran , Aouizerat Bradley , Ye Yi
Published: August 2022

Head and neck cancer (HNC) is the seventh most common cancer worldwide, the majority being oral squamous cell carcinoma. Despite advances in cancer diagnosis and treatment, the survival rate of patients with HNC remains stagnant. The cancer‐nerve interaction has been recognized as an important driver of cancer progression. Schwann cells, a type of peripheral glia, have been implicated in promoting cancer cell growth, migration, dispersion, and invasion into the nerve in many cancers. Here, it is demonstrated that the presence of Schwann cells makes oral cancer cells more aggressive by promoting their proliferation, extracellular matrix breakdown, and altering cell metabolism. Furthermore, oral cancer cells became larger, more circular, with more projections and nuclei following co‐culturing with Schwann cells. RNA‐sequencing analysis in oral cancer cells following exposure to Schwann cells shows corresponding changes in genes involved in the hallmarks of cancer and cell metabolism; the enriched KEGG pathways are spliceosome, RNA transport, cell cycle, axon guidance, signaling pathways regulating pluripotency of stem cells, cAMP signaling, WNT signaling, proteoglycans in cancer and PI3K‐Akt signaling. Taken together, these results suggest a significant role for Schwann cells in facilitating oral cancer progression, highlighting their potential as a target to treat oral cancer progression.
Integrated Self‐Powered Sensors Based on 2D Material Devices
Authors: Huo Ziwei , Wei Yichen , Wang Yifei , Wang Zhong Lin , Sun Qijun
Published: August 2022

With the development of the Internet of Things, there is an increasing need for clean energy and large‐scale sensory systems. Triboelectric/piezoelectric nanogenerators (TENGs/PENGs), have attracted considerable attention as a new type of power generation terminal, which can harvest surrounding energy and convert it into electrical energy. To improve the output performance of nanogenerators (NGs) and diversify related applications, 2D materials with high carrier mobility and excellent piezoelectric properties can be directly used or integrated as different types of self‐powered sensors. In this review, the authors first introduce the excellent piezoelectric and optoelectronic properties of 2D materials, followed by the triboelectric series of 2D materials used in TENGs. The categories of integrated self‐powered sensors based on 2D materials are then summarized according to their different structures and compositions. We also discuss in detail the recent applications of integrated self‐powered sensors based on 2D materials from five aspects. Finally, the challenges and outlooks in the research field of self‐powered sensors are featured. Given the continuous development of self‐powered sensors based on 2D materials, they are considered to have significant potential for applications in biomedicine, environmental detection, human motion monitoring, energy harvesting, and smart wearable devices.
Accurate Wavelength Tracking by Exciton Spin Mixing
Authors: Kirch Anton , Bärschneider Toni , Achenbach Tim , Fries Felix , Gmelch Max , Werberger Robert , Guhrenz Chris , Tomkevičienė Aušra , Benduhn Johannes , Eychmüller Alexander , Leo Karl , Reineke Sebastian
Published: August 2022

Wavelength‐discriminating systems typically consist of heavy benchtop‐based instruments, comprising diffractive optics, moving parts, and adjacent detectors. For simple wavelength measurements, such as lab‐on‐chip light source calibration or laser wavelength tracking, which do not require polychromatic analysis and cannot handle bulky spectroscopy instruments, lightweight, easy‐to‐process, and flexible single‐pixel devices are attracting increasing attention. Here, a device is proposed for monotonously transforming wavelength information into the time domain with room‐temperature phosphorescence at the heart of its functionality, which demonstrates a resolution down to 1 nm and below. It is solution‐processed from a single host–guest system comprising organic room‐temperature phosphors and colloidal quantum dots. The share of excited triplet states within the photoluminescent layer is dependent on the excitation wavelength and determines the afterglow intensity of the film, which is tracked by a simple photodetector. Finally, an all‐organic thin‐film wavelength sensor and two applications are demonstrated where this novel measurement concept successfully replaces a full spectrometer.
Discovery of New Plasmonic Metals via High‐Throughput Machine Learning
Authors: Shapera Ethan P. , Schleife André
Published: August 2022

The field of plasmonics aims to manipulate and control light through nanoscale structuring and choice of materials. Finding materials with low‐loss response to an applied optical field while exhibiting collective oscillations due to intraband transitions is an outstanding challenge. This is viewed as a materials selection problem that bridges the gap between the large number of candidate materials and the high computational cost to accurately compute their individual optical properties. To address this, online databases that compile computational data for numerous properties of tens to hundreds of thousands of materials are combined with first‐principles simulations and the Drude model. By means of density functional theory (DFT), a training set of geometry‐dependent plasmonic quality factors for ≈1000 materials is computed and subsequently random‐forest regressors are trained on these data. Descriptors are limited to symmetry, quantities obtained using the chemical formula, and the Mendeleev database, which allows to rapidly screen 7445 candidates on Materials Project. Using DFT to compute quality factors for the 233 most promising materials, AlCu3, ZnCu, and ZnGa3 are identified as excellent potential new plasmonic metals. This finding is substantiated by analyzing their electronic structure and interband optical properties in detail.
Highly Stable Lead‐Free Perovskite Single Crystals with NIR Emission Beyond 1100 nm
Authors: Liu Zhuang , Qin Xian , Chen Qihao , Chen Qiushui , Jing Yuhang , Zhou Zhonghao , Zhao Yong Sheng , Chen Jingsheng , Liu Xiaogang
Published: August 2022

Materials that emit in the near‐infrared (NIR) region are at the forefront of both research and industry, mainly due to their wide applications in national security, nondestructive bioimaging, long‐wave communications, and photothermal conversion for medical care. As a key member of the luminescent materials family, metal halide perovskites have been intensively demonstrated to emit light in ultraviolet and visible regions. However, NIR‐emitting perovskites suffer from severe limitations, such as low photoluminescence quantum yield and poor chemical/optical stability, thereby preventing them from practical applications. Herein, the synthesis and growth of Cs2MoCl6 and Cs2WCl6 perovskite single crystals with ultrahigh chemical and optical resistance to heat, moisture, polar solvents, and high‐energy radiation is reported. Upon ultraviolet or blue excitation, these lead‐free single crystals emit light beyond 1100 nm, the longest wavelength ever reported for perovskite hosts. Mechanistic studies indicate that self‐trapped excitons are responsible for the NIR emission. The authors fabricate optoelectronic devices using these single crystals and demonstrate their broad applications in noninvasive palm vein imaging, night vision, and nondestructive food analysis. These results may stimulate research in the development of high‐efficiency NIR perovskite phosphors for fast, accurate biometric identification and food inspection.
Sustainable Hydrogen Production Using Group‐10 Metal Chalcogenides as Low‐Cost Effective Electrocatalysts
Authors: D'Olimpio Gianluca , Santoro Sergio , Kuo Chia‐Nung , Ottaviano Luca , Lue Chin Shan , Boukhvalov Danil W. , Politano Antonio
Published: August 2022

Clean hydrogen production is crucial to the prospects of the energy transition. Electrochemical water splitting is one of the most promising tools for the sustainable and efficient production of hydrogen. One of the main open challenges is the replacement of precious Pt for electrodes with new materials combining cheapness, robustness to CO poisoning, and fast reaction kinetics. Group‐10 metal chalcogenides represent suitable candidates to address all main open challenges in the quest for alternative materials to pure Pt as electrocatalysts, with the further advantage of the ease of their synthesis as both bulk crystals and nanostructures. All compounds of this class of materials show surface stability, chemical inertness toward CO adsorption, and electrode durability in acidic and alkaline environments. Here, the physicochemical mechanisms ruling hydrogen production with group‐10 metal chalcogenides are focused on by combining surface‐science experiments and theory. Especially, the Tafel slope in Pt3Te4 nanocrystals and NiTe2 nanotubes is as low as 32 and 59 mV dec−1, respectively, making them competitive with state‐of‐the‐art reference materials Pt and Pt/C already in the first implementation. Moreover, the presence of massless Dirac‐cone electrons in many group‐10 metal chalcogenides, with an intrinsically large electron mobility, is naturally beneficial for fast electron transfer, and correspondingly, for fast reaction kinetics. These results pave the way for the advent of this new class of materials in electrocatalysis, and for sustainable hydrogen production through water splitting.