bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling Waterlogging Impacts on Crop Growth: A Review of Aeration Stress Definition in Crop Models and Sensitivity Analysis of APSIM
Authors: Githui Faith , Beverly Craig , Aiad Misbah , McCaskill Malcolm , Liu Ke , Harrison Matthew Tom
Published: July 2022

Currently, crop physiological responses to waterlogging are considered only in a few crop models and in a limited way. Here, we examine the process bases of seven contemporary models developed to model crop growth in waterlogged conditions. The representation of plant recovery in these models is over-simplified, while plant adaptation or phenotypic plasticity due to waterlogging is often not considered. Aeration stress conceptualisation varies from the use of simple multipliers in equations describing transpiration and biomass to complex linkages of aeration-deficit factors with root growth, transpiration and nitrogen fixation. We recommend further studies investigating more holistic impacts and multiple stresses caused by plant behaviours driven by soils and climate. A sensitivity analysis using one model (a developer version of APSIM) with default parameters showed that waterlogging has the greatest impact on photosynthesis, followed by phenology and leaf expansion, suggesting a need for improved equations linking waterlogging to carbon assimilation. Future studies should compare the ability of multiple models to simulate real and in situ effects of waterlogging stress on crop growth using consistent experimental data for initialisation, calibration and validation. We conclude that future experimental and modelling studies must focus on improving the extent to which soil porosity, texture, organic carbon and nitrogen and plant-available water affect waterlogging stress, physiological plasticity and the ensuing temporal impacts on phenology, growth and yield.
The BosWash Infrastructure Biome and Energy System Succession
Authors: Wright Jessica , Ackley Robert , Gopal Sucharita , Phillips Nathan
Published: July 2022

The BosWash corridor is a megalopolis, or large urbanized region composed of interconnected transportation, infrastructure, physiography, and sociopolitical systems. Previous work has not considered the BosWash corridor as an integrated, holistic ecosystem. Building on the emerging field of infrastructure ecology, the region is conceptualized here as an infrastructure biome, and this concept is applied to the region’s energy transition to a post-fossil fueled heating sector, in analogy to ecosystem succession. In this conception, infrastructure systems are analogous to focal species. A case study for an energy succession from an aging natural gas infrastructure to a carbon-free heating sector is presented, in order to demonstrate the utility of the infrastructure biome framework to address climate and energy challenges facing BosWash communities. Natural gas is a dominant energy source that emits carbon dioxide when burned and methane when leaked along the process chain; therefore, a transition to electricity is widely seen as necessary toward reducing greenhouse gas emissions. Utilizing an infrastructure biome framework for energy policy, a regional gas transition plan akin to the Regional Greenhouse Gas Initiative is generated to harmonize natural gas transition within the BosWash infrastructure biome and resolve conflict arising from a siloed approach to infrastructure management at individual city and state levels. This work generates and utilizes the novel infrastructure biome concept to prescribe a regional energy policy for an element of infrastructure that has not previously been explored at the regional scale—natural gas.
Controlling Chiral Self-Sorting in Truxene-Based Self-Assembled Cages
Authors: Benchohra Amina , Séjourné Simon , Labrunie Antoine , Miller Liam , Charbonneau Enzo , Carré Vincent , Aubriet Frédéric , Allain Magali , Sallé Marc , Goeb Sébastien
Published: July 2022

Coordination driven self-assembly of achiral components, i.e., hexa-alkylated truxene ligands (L) with bis-metallic complexes (M2), afforded three chiral face-rotating stereoisomer polyhedra (M6L2). By tuning the length of the alkyl chains as well as the distance between both ligands facing each other in the self-assemblies (M6L2), one can control the diastereomeric distribution between the expected homo- and hetero-chiral structures.
Factor XIII Measurement and Substitution in Trauma Patients after Admission to an Intensive Care Unit
Authors: Katzensteiner Moritz , Ponschab Martin , Schöchl Herbert , Oberladstätter Daniel , Zipperle Johannes , Osuchowski Marcin , Schlimp Christoph J.
Published: July 2022

Trauma patients admitted to an intensive care unit (ICU) may potentially experience a deficiency of coagulation factor thirteen (FXIII). In this retrospective cohort study conducted at a specialized trauma center, ICU patients were studied to determine the dependency of FXIII activity levels on clinical course and substitution with blood and coagulation products. A total of 189 patients with a median injury severity score (ISS) of 25 (16–36, IQR) were included. Abbreviated injury scores for extremities (r = −0.38, p < 0.0001) but not ISS (r = −0.03, p = 0.45) showed a negative correlation with initial FXIII levels. Patients receiving FXIII concentrate presented with a median initial FXIII level of 54 (48–59)% vs. 88 (74–108)%, p < 0.0001 versus controls; they had fewer ICU-free days: 17 (0–22) vs. 22 (16–24), p = 0.0001; and received higher amounts of red blood cell units: 5 (2–9) vs. 4 (1–7), p < 0.03 before, and 4 (2–7) vs. 1 (0–2), p < 0.0001 after FXIII substitution. Matched-pair analyses based on similar initial FXIII levels did not reveal better outcome endpoints in the FXIII-substituted group. The study showed that a low initial FXIII level correlated with the clinical course in this trauma cohort, but a substitution of FXIII did not improve endpoints within the range of the studied FXIII levels. Future prospective studies should investigate the utility of FXIII measurement and lower threshold values of FXIII, which trigger substitution in trauma patients.
Assessing Patients with Alpha-1 Antitrypsin Deficiency for Corneal Refractive Surgery: A Review and Clinical Experience
Authors: Moshirfar Majid , Kelkar Neil , Ronquillo Yasmyne C. , Hoopes Phillip C.
Published: July 2022

Alpha-1 Antitrypsin Deficiency (AATD) is an autosomal inheritable disorder that impairs the protease inhibitor alpha-1 antitrypsin. This disorder presents with various systemic effects, including liver cirrhosis, centrilobular emphysema, and ocular manifestations. Performing corneal refractive surgery in patients with AATD raises concerns regarding the increased rates of corneal erosions, corneal ulcerations, potential developing descemetoceles, and other ocular manifestations. Patient outcomes for laser-assisted in situ keratomileuses (LASIK), photorefractive keratectomy (PRK), small incision lenticule extraction (SMILE), and other ocular corrective surgeries are lacking in this population. This article provides experiences performing corneal refractive surgery, discusses the current understanding of AATD, including its ocular manifestations, and explores factors to consider when evaluating patients for corneal procedures. The aim of this paper is to address the manifestations of AATD prior to performing corrective vision surgery.
Refractive Characteristics and Related Factors of Amblyopia after Lamellar Keratoscleroplasty in Children with Limbal Dermoids
Authors: Luo Surong , Xu Jianjiang , Shao Tingting , Qu Xiaomei
Published: July 2022

We examined the refractive characteristics and related factors of amblyopia in pediatric patients with limbal dermoids undergoing lamellar keratoscleroplasty. Forty-one children (mean age: 56.15 ± 22.47 months) were enrolled. Cycloplegic refraction, corneal topography, and anterior segment photography were performed. The corneal topographic and distribution characteristics of the refractive state were summarized, and the relationship between limbal dermoid invasion size and the refractive state was analyzed. The relationship between invasion size and amblyopia severity and the effect of clinical intervention at different times on amblyopia treatment were also analyzed. The spherical power distribution was −1.0–+10.75 D (average: +4.79 ± 3.09 D). The cylinder power was −1.25–−8.75 D (average: −4.19 ± 1.93 D). The axial range of astigmatism was 10–180° (average: 103.54 ± 58.16°). Equivalent spherical refraction was −3.88–+7.76 D (average: +2.70 ± 3.08 D). Twenty-five, fifteen, and one case had limboid dermoid invasion of the central circular zone (CCZ), paracentral annular zone (PCZ), and corneal limbus within 1 mm, respectively. Corneal topography of 39 patients showed flat, steep, and mean curvatures of 38.48 ± 2.12 D, 43.29 ± 1.97 D, and 40.70 ± 1.48 D, respectively. The mean astigmatism was 4.80 ± 2.93 D in the 3-mm optical region. Astigmatism was higher in CCZ than in PCZ invasion (p < 0.05). Postoperative visual acuity was positively correlated with patients’ age and amblyopia treatment duration (r = 0.392, p = 0.048; r = 0.488, p = 0.011), and was negatively correlated with astigmatism (r = −0.646, p < 0.001). High hyperopia and astigmatism are the dominant refractive errors in patients with limbal dermoids undergoing lamellar keratoscleroplasty.
Risk-Taking Behavior among Suicide Attempters
Authors: Abdoli Nasrin , Salari Nader , Farnia Vahid , Khodamoradi Mehdi , Jahangiri Somayeh , Mohammadi Masoud , Brühl Annette , Sadeghi-Bahmani Dena , Brand Serge
Published: July 2022

Background: Suicidal behavior is a major mental health concern both for the individual and for the public health. Among others, suicidal behavior is associated with impulsivity, risk taking, pain tolerance, and a state of overarousal. In the present study, we investigated if suicide attempters (SAs) reported higher scores for risk-taking when compared with healthy controls (HC) of the general population. Methods: A total of 616 individuals (mean age: 27.07 years; 51.5% females) took part in the study; of those, 240 (39%) were individuals with a suicide attempt (SA) within a time lapse of one to three months, and 376 (61%) were healthy controls (HC). Participants completed a series of self-rating questionnaires covering sociodemographic information, risk-taking (Risk-Taking Questionnaire 18; RT-18), and suicidal behavior (Suicide Behaviors Questionnaire-Revised; SBQ-R). Results: Compared with HCs, individuals with SA reported higher risk-taking and suicidal behavior scores. The risk-taking questionnaire yielded a four-factor solution: Thrill and sensation seeking; Cautious procedure; Cautious decision making; Impulsive behavior. Compared with HCs, SAs showed the highest scores for thrill and sensation seeking and impulsive behavior. Conclusions: Compared with healthy controls, individuals reporting a recent suicide attempt also reported a higher propensity to thrill and sensation seeking and impulsive behavior as a proxy of risk-taking behavior. The present results corroborate the notion that, among others, suicide attempts appeared to be less related to premeditation, but rather to impulsive and thus spontaneous behavior.
Impact of the COVID-19 Pandemic on the Diagnosis and Prognosis of Melanoma
Authors: Martinez-Lopez Antonio , Diaz-Calvillo Pablo , Cuenca-Barrales Carlos , Montero-Vilchez Trinidad , Sanchez-Diaz Manuel , Buendia-Eisman Agustin , Arias-Santiago Salvador
Published: July 2022

Background: Early detection of melanoma is one of the main diagnostic goals of dermatologists worldwide, due to the increasing incidence of the disease in our environment. However, the irruption of the SARS-CoV-2 pandemic has posed a challenge to global healthcare, forcing systems to focus their resources on the fight against COVID-19. Methods: Retrospective cohort study. The exposed cohort were patients diagnosed with melanoma in the year after the general confinement in Spain (15 March 2020) and the unexposed cohort were patients with melanoma diagnosed in the previous year. Results: 130 patients were included. No differences were observed between demographic characteristics in both cohorts. The mean Breslow of melanoma before the onset of the pandemic was 1.08, increasing to 2.65 in the year after the onset of the pandemic (p < 0.001). On the other hand, the percentage of melanomas in situ decreased from 38.96% to 16.98% in the year after the declaration of the state of alarm in Spain. Conclusions: The SARS-CoV-2 outbreak has led to a reduction in the early diagnosis of melanoma, with an increase in invasive melanomas with poor prognosis histological factors. This could lead to an increase in melanoma-related mortality in the coming years in our environment.
Maternal Immune Cell and Cytokine Profiles to Predict Cardiovascular Risk Six Months after Preeclampsia
Authors: Murphy Malia S. Q. , Benton Samantha J. , Cox Brian , Nerenberg Kara , McComb Scott , Krishnan Lakshmi , Weeratna Risini D. , Paré Jean-François , Dingwall-Harvey Alysha L. J. , Bainbridge Shannon A. , Gruslin Andrée , Gaudet Laura M.
Published: July 2022

Women who develop preeclampsia (PE) are at high risk for cardiovascular disease (CVD). Early identification of women with PE who may benefit the most from early cardiovascular risk screening and interventions remains challenging. Our objective was to assess whether cytokine and immune cell profiles after PE are helpful in distinguishing women at low and high CVD risk at 6-months postpartum. Individuals who developed PE were followed for immune cell phenotyping and plasma cytokine quantification at delivery, at 3-months, and at 6-months postpartum. Lifetime CVD risk was assessed at 6-months postpartum, and the immune cell and cytokine profiles were compared between risk groups at each time point. Among 31 participants, 18 (58.1%) exhibited high CVD-risk profiles at 6-months postpartum. The proportion of circulating NK-cells was significantly lower in high-risk participants at delivery (p = 0.04). At 3-months postpartum, high-risk participants exhibited a lower proportion of FoxP3+ regulatory T-cells (p = 0.01), a greater proportion of CD8+ T cells (p = 0.02) and a lower CD4+:CD8+ ratio (p = 0.02). There were no differences in immune cell populations at 6-months postpartum. There were no differences in plasma cytokines levels between risk groups at any time point. Subtle differences in immune cell profiles may help distinguish individuals at low and high CVD risk in the early postpartum period and warrants further investigation.
Volumetric Changes after Coblation Ablation Tongue (CAT) in Obstructive Sleep Apnea Patients
Authors: Lu Yi-An , Wang Chao-Jan , Chiang Yen-Ting , Li Hsueh-Yu
Published: July 2022

Background: Obstruction of the tongue is commonly seen in patients with obstructive sleep apnea (OSA). This study proposed whole tongue treatment using coblation ablation tongue (CAT) and aimed to explore the potential association between the dimensions of a tongue and the severity of OSA, to inspect volumetric changes of the tongue after CAT, and to search for factors that influence outcome of tongue volume change. Methods: The prospective study enrolled 12 OSA patients (all male, average age: 35 years, average apnea/hypopnea index (AHI): 45.5 event/h, average body mass index (BMI): 27.0 kg/m2). All patients received multi-level sleep surgery including septomeatoplasty, uvulopalatopharyngoplasty, and CAT. The CAT used a coblation wand to perform uniform multiple ablations (15 points, body −6, base −9) on dorsal tongue. Three dimensions of the tongue (length, height, and width) and tongue volume were measured from head and neck computed tomography. The perioperative changes in the tongue dimension/volume and AHI were assessed at baseline and 3 months after surgery. Result: The baseline tongue length and AHI had a significant correlation (r = 0.60, p = 0.02). The multi-level surgery significantly improved AHI (43.8 vs. 23.7, p = 0.008). The CAT significantly decreased tongue volume from 91.3 to 85.6 cm3 (p = 0.02), with an average tongue volume reduction of 5.7 cm3 per person and 0.38 cm3 per ablation. Further outcome analysis showed surgical success was significantly higher in patients with non-hypertrophic lingual tonsils (grade I/II) than in those with hypertrophic lingual tonsils (grade III/IV) (p = 0.02). Conclusion: Length of the tongue is associated with the severity of OSA. The CAT significantly decreased the tongue volume in OSA patients. A volumetric reduction of 0.38 cm3 per ablation could be useful in the optimal reduction of tongue for OSA. The CAT significantly enlarged the retroglossal airway volume, which is related to the non-hypertrophic lingual tonsil.
Special Issue: New Advances in Kidney Transplantation
Authors: Mor Eytan
Published: July 2022

This Special Issue in renal transplantation covers a variety of clinical and research areas in kidney transplantation [...]
Dermatophytomas: Clinical Overview and Treatment
Authors: Gupta Aditya K. , Wang Tong , Cooper Elizabeth A.
Published: July 2022

Dermatophytomas are characterized as a hyperkeratotic fungal mass in the subungual space, showing as dense white or yellow, typically in longitudinal streaks or patches. Masses can be visualized by traditional microscopy or histology. Newer technologies such as dermoscopy and optical coherence tomography also provide visual features for dermatophytoma diagnosis. The density of fungal mass, and lack of adherence to the nail structures, as well as possible biofilm development, may play a role in the reduction in drug penetration and subsequent lack of efficacy with traditional oral therapies such as terbinafine and itraconazole. A combination of drug treatment with mechanical or chemical debridement/avulsion has been recommended to increase efficacy. The topical antifungal solutions such as tavaborole, efinaconazole, and luliconazole may reach the dermatophytoma by both the transungual and subungual routes, due to low affinity for keratin and low surface tension. Current data indicates these topicals may provide efficacy for dermatophytoma treatment without debridement/avulsion. Similarly, fosravuconazole (F-RVCZ) has an improved pharmacological profile versus ravuconazole and may be an improved treatment option versus traditional oral therapies. The availability of improved treatments for dermatophytomas is crucial, as resistance to traditional therapies is on the increase.
An Algorithm for Elective Amputation Combined with Targeted Muscle Reinnervation in Complex Regional Pain Syndrome—A Perspective
Authors: Aman Martin , Biglari Bahram , Thielen Mirjam , Boecker Arne H. , Stolle Annette , Schwarz Daniel , Gazyakan Emre , Kneser Ulrich , Harhaus Leila
Published: July 2022

Complex regional pain syndrome (CRPS) can result in a devastating condition. For a small number of patients, there is a non-response to any existing multimodal therapies and they ultimately request amputation. Such a drastic and final decision is not easy to take for both the patient and the surgeon and requires careful and interdisciplinary assessments and considerations. Furthermore, new surgical procedures, such as targeted muscle reinnervation (TMR) and hybrid prosthetic fitting, and multidisciplinary board advice should be included when considering amputation. In order to help other therapeutic teams in decision making for such rare but more than demanding cases, we aimed to propose an advanced algorithm for amputation indications in CRPS patients combining all these new factors. This algorithm consists of extensive pre-operative psychiatric assessment, diagnostic hybrid prosthetic fitting including fMRI analyses, multidisciplinary board advice as well as targeted muscle reinnervation and amputation procedures with final prosthetic fitting and rehabilitation. By involving multiple disciplines, this algorithm should provide optimized and individualized patient treatment on the one hand and a reliable base for decision making for therapists on the other.
How the First Year of the COVID-19 Pandemic Impacted Patients’ Hospital Admission and Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula
Authors: Martelli Eugenio , Sotgiu Giovanni , Saderi Laura , Federici Massimo , Sangiorgi Giuseppe , Zamboni Matilde , Martelli Allegra R. , Accarino Giancarlo , Bianco Giuseppe , Bonanno Francesco , Bracale Umberto M. , Cappello Enrico , Cioffi Giovanni , Colacchio Giovanni , Crinisio Adolfo , De Vivo Salvatore , Dionisi Carlo Patrizio , Flora Loris , Impedovo Giovanni , Intrieri Francesco , Iorio Luca , Maritati Gabriele , Modugno Piero , Monaco Mario , Natalicchio Giuseppe , Palazzo Vincenzo , Petrosino Fernando , Pompeo Francesco , Pulli Raffaele , Razzano Davide , Ruggieri Maurizio R. , Ruotolo Carlo , Sangiuolo Paolo , Vigliotti Gennaro , Volpe Pietro , Biello Antonella , Boggia Pietro , Boschetti Michelangelo , Centritto Enrico M. , Condò Flavia , Cucciolillo Lucia , D’Amodio Amodio S. , De Laurentis Mario , Desantis Claudio , Di Lella Daniela , Di Nardo Giovanni , Disabato Angelo , Ficarelli Ilaria , Gasparre Angelo , Giordano Antonio N. , Luongo Alessandro , Massara Mafalda , Molinari Vincenzo , Padricelli Andrea , Panagrosso Marco , Petrone Anna , Pisanello Serena , Prunella Roberto , Tedesco Michele , Settembrini Alberto M.
Published: July 2022

Background: To investigate the effects of the COVID-19 lockdowns on the vasculopathic population. Methods: The Divisions of Vascular Surgery of the southern Italian peninsula joined this multicenter retrospective study. Each received a 13-point questionnaire investigating the hospitalization rate of vascular patients in the first 11 months of the COVID-19 pandemic and in the preceding 11 months. Results: 27 out of 29 Centers were enrolled. April-December 2020 (7092 patients) vs. 2019 (9161 patients): post-EVAR surveillance, hospitalization for Rutherford category 3 peripheral arterial disease, and asymptomatic carotid stenosis revascularization significantly decreased (1484 (16.2%) vs. 1014 (14.3%), p = 0.0009; 1401 (15.29%) vs. 959 (13.52%), p = 0.0006; and 1558 (17.01%) vs. 934 (13.17%), p < 0.0001, respectively), while admissions for revascularization or major amputations for chronic limb-threatening ischemia and urgent revascularization for symptomatic carotid stenosis significantly increased (1204 (16.98%) vs. 1245 (13.59%), p < 0.0001; 355 (5.01%) vs. 358 (3.91%), p = 0.0007; and 153 (2.16%) vs. 140 (1.53%), p = 0.0009, respectively). Conclusions: The suspension of elective procedures during the COVID-19 pandemic caused a significant reduction in post-EVAR surveillance, and in the hospitalization of asymptomatic carotid stenosis revascularization and Rutherford 3 peripheral arterial disease. Consequentially, we observed a significant increase in admissions for urgent revascularization for symptomatic carotid stenosis, as well as for revascularization or major amputations for chronic limb-threatening ischemia.
Diagnostic Performance of the Rapid Antigen Test as a Screening Tool for SARS-CoV-2 Infection in the Emergency Department
Authors: Lee Heekyung , Kang Hyunggoo , Cho Yongil , Oh Jaehoon , Lim Tae-Ho , Ko Byuk-Sung , Lee Juncheol
Published: July 2022

The rapid antigen test (RAT) has been adopted as a screening tool for SARS-CoV-2 infection in many emergency departments (EDs). We aimed to investigate the diagnostic value of the accuracy of the SARS-CoV-2 RAT as a screening tool in the ED. This retrospective observational study included patients who underwent both RAT and RT–PCR and visited the ED from 1 December 2021 to 15 March 2022. RAT and RT–PCR were performed by appropriately trained physicians. We performed detailed analyses using the E gene cyclic threshold (Ct) values of RT–PCR. Out of a total of 1875 patients, 348 (18.6%) had positive and 1527 (81.4%) had negative RT–PCR results. The overall sensitivity, specificity, positive predictive value, and negative predictive value of the RAT were 67.8%, 99.9%, 99.6%, and 93.2%, respectively. The E gene Ct value was significantly lower in the RAT-positive patients than in the RAT-negative patients (18.5 vs. 25.3, p < 0.001). When the E gene Ct cutoff was 30.0, 25.0, 20.0, and 15.0, the sensitivity of the RAT was 71.9%, 80.3%, 93.0%, and 97.8%, respectively. The sensitivity of the RAT could be considered high in patients with a high viral load, and the RAT could be used as a screening tool in the ED.
Modeling the Temperature Field in Frozen Soil under Buildings in the City of Salekhard Taking into Account Temperature Monitoring
Authors: Filimonov Mikhail , Kamnev Yaroslav , Shein Aleksandr , Vaganova Nataliia
Published: July 2022

Most residential buildings and capital structures in the permafrost zone are constructed on the principle of maintaining the frozen state of the foundation soils. The changing climate and the increasing anthropogenic impact on the environment lead to changes in the boundaries of permafrost. These changes are especially relevant in the areas of piling foundations of residential buildings and other engineering structures located in the northern regions since they can lead to serious accidents caused by the degradation of permafrost and decrease the bearing capacity of the soil in such areas. Therefore, organization of temperature monitoring and forecasting of temperature changes in the soil under the buildings is an actual problem. To solve this problem, we use computer simulation methods of three-dimensional nonstationary thermal fields in the soil in combination with real-time monitoring of the temperature of the soil in thermometric wells. The developed approach is verified by using the temperature monitoring data for a specific residential building in the city of Salekhard. Comparison of the results of numerical calculations with experimental data showed good agreement. Using the developed computer software, nonstationary temperature fields under this building are obtained and, on this basis, the bearing capacities of all piles are calculated and a forecast of their changes in the future is given. To avoid decreasing the bearing capacity of piles it is necessary to prevent the degradation of permafrost and to supply the thermal stabilization of the soil. The proposed approach, based on a combination of the soil temperature monitoring and computer modeling methods, can be used to improve geotechnical monitoring methods.
Spatiotemporal Variation of Land Surface Temperature in Henan Province of China from 2003 to 2021
Authors: Li Shifeng , Qin Zhihao , Zhao Shuhe , Gao Maofang , Li Shilei , Liao Qianyu , Du Wenhui
Published: July 2022

Land surface temperature (LST) is a key parameter closely related to various land surface processes and surface-atmosphere interactions. Analysis of spatiotemporal variation of time-series LST may provide useful information to understand eco-climatic characteristics. In this study, the spatiotemporal pattern of LST and its trend characteristics in Henan Province were examined based on MODIS LST products from 2003 to 2021. In addition, the influences of land cover types, Nighttime Light data (NTL) and Normalized Difference Moisture Index (NDMI) on LST variation were analyzed. The results indicated that: (i) The LST showed slight and rapid decreasing trend for 2004–2010 and 2018–2020, respectively, whereas an obvious increasing and slight increasing trend occurred for 2010–2013 and 2014–2018. In terms of spatial pattern, high-temperature, and sub-high-temperature were mainly distributed in the central part of the province with higher level of industrialization and urbanization at the annual, spring, summer, and daytime scales. While in fall, winter, and the nighttime, the spatial distribution of LST exhibited decreased trend from the southern part to the northern part of the province, the largest Standard Deviation (STD) was observed in summer. (ii) The interannual variation rate of LST was 0.08 °C/Y. The increasing trend mainly occurred in urban and built-up areas. At the seasonal scales, the rising rate decreased sequentially in the order of fall, winter, spring, and summer. In addition, the rising rate in the daytime was higher than that in the nighttime. (iii) LST increased along with the expansion of urban and built-up lands, except in winter. At the annual scales, 84.69% of areas with NTL data exhibited a positive correlation with LST, and NDMI in the western part with high elevation presented a significantly positive correlation to LST, while a significantly negative correlation occurred in urban and built-up areas. The cooling effect of NDMI on LST in the daytime was greater than that in the nighttime. In cropland areas, LST showed a non-significant correlation with NDMI at the annual scale, and a significantly negative correlation with NDMI in spring, summer, and fall. The influence mechanism of cropland on the variation of LST at different timescales needs to be further explored. These findings might provide some hints to understand climate change and its causes in the province.
The Impact of Kefir on Epidermal Water Homeostasis in Healthy Human Skin
Authors: Alves Emília , Gregório João , Rijo Patrícia , Rosado Catarina , Rodrigues Luís Monteiro
Published: July 2022

Kefir, a symbiotic consortium of diverse bacteria and yeasts, is one of the most popular probiotic foods on the market. Its consumption has been referred to as beneficial in human skin health, namely in the reinforcement of skin’s barrier function. This benefit likely results from the productive activity of lactic acid bacteria during kefir fermentation. Lactic acid is naturally present in the skin, and actively contributes to epidermal water dynamics and “barrier.” Few studies have been conducted regarding the impact of probiotic consumption in human epidermal water homeostasis. Therefore, this study was designed to explore the impact of the regular consumption of kefir on the skin water dynamics in a group of participants with healthy skin. Participants (n = 27) were healthy female volunteers from whom twelve consumed 100 mL of kefir every day for eight weeks as part of their diet. The remaining (untreated) participants served as the control group. Epidermal water balance was assessed by measuring transepidermal water loss (TEWL) and stratum corneum (SC) hydration on three different occasions—at baseline (T0), after four weeks (T4) and after eight weeks (T8) of interventive kefir consumption. Our study revealed a significant reduction in TEWL (p = 0.043) in the kefir group after eight weeks of regular consumption. In the same period, no differences were found for TEWL in the control group (p = 0.997). Regarding hydration, skin dryness was progressive in the control group, with a significant reduction in SC hydration (p = 0.002) at T8 in comparison to T0. In the kefir group, SC hydration was preserved between T0 and T8 (p = 0.997), which we believe to be related to epidermal “barrier” reinforcement. Our study seems to confirm that the regular consumption of kefir does improve cutaneous water balance even in healthy skin.
Dithymoquinone Analogues as Potential Candidate(s) for Neurological Manifestation Associated with COVID-19: A Therapeutic Strategy for Neuro-COVID
Authors: Moin Afrasim , Huwaimel Bader , Alobaida Ahmed , Break Mohammed Khaled Bin , Iqbal Danish , Unissa Rahamat , Jamal Qazi Mohammad Sajid , Hussain Talib , Sharma Dinesh C. , Rizvi Syed Mohd Danish
Published: July 2022

The COVID-19 era has prompted several researchers to search for a linkage between COVID-19 and its associated neurological manifestation. Toll-like receptor 4 (TLR-4) acts as one such connecting link. spike protein of SARS-CoV-2 can bind either to ACE-2 receptors or to TLR-4 receptors, leading to aggregation of α-synuclein and neurodegeneration via the activation of various cascades in neurons. Recently, dithymoquinone has been reported as a potent multi-targeting candidate against SARS-CoV-2. Thus, in the present study, dithymoquinone and its six analogues were explored to target 3CLpro (main protease of SARS-CoV-2), TLR4 and PREP (Prolyl Oligopeptidases) by using the molecular docking and dynamics approach. Dithymoquinone (DTQ) analogues were designed in order to investigate the effect of different chemical groups on its bioactivity. It is noteworthy to mention that attention was given to the feasibility of synthesizing these analogues by a simple photo-dimerisation reaction. The DTQ analogue containing the 4-fluoroaniline moiety [Compound (4)] was selected for further analysis by molecular dynamics after screening via docking-interaction analyses. A YASARA structure tool built on the AMBER14 force field was used to analyze the 100 ns trajectory by taking 400 snapshots after every 250 ps. Moreover, RMSD, RoG, potential energy plots were successfully obtained for each interaction. Molecular docking results indicated strong interaction of compound (4) with 3CLpro, TLR4 and PREP with a binding energy of −8.5 kcal/mol, −10.8 kcal/mol and −9.5 kcal/mol, respectively, which is better than other DTQ-analogues and control compounds. In addition, compound (4) did not violate Lipinski’s rule and showed no toxicity. Moreover, molecular dynamic analyses revealed that the complex of compound (4) with target proteins was stable during the 100 ns trajectory. Overall, the results predicted that compound (4) could be developed into a potent anti-COVID agent with the ability to mitigate neurological manifestations associated with COVID-19.
Gene Dysregulation in the Adult Rat Paraventricular Nucleus and Amygdala by Prenatal Exposure to Dexamethasone
Authors: Rivet Tyler R. , Lalonde Christine , Tai T. C.
Published: July 2022

Fetal programming is the concept that maternal stressors during critical periods of fetal development can alter offspring phenotypes postnatally. Excess glucocorticoids can interact with the fetus to effect genetic and epigenetic changes implicated in adverse developmental outcomes. The present study investigates how chronic exposure to the synthetic glucocorticoid dexamethasone during late gestation alters the expression of genes related to behavior in brain areas relevant to the regulation and function of the hypothalamic–pituitary–adrenal axis. Pregnant Wistar Kyoto rats received subcutaneous injections of dexamethasone (100 μg/kg) daily from gestational day 15–21 or vehicle only as sham controls. The amygdala and paraventricular nucleus (PVN) were micro-punched to extract mRNA for reverse transcription and quantitative polymerase chain reaction for the analysis of the expression of specific genes. In the PVN, the expression of the glucocorticoid receptor NR3C1 was downregulated in female rats in response to programming. The expression of CACNA1C encoding the Cav1.2 pore subunit of L-type voltage-gated calcium channels was downregulated in male and female rats prenatally exposed to dexamethasone. Collectively, the results suggest that prenatal exposure to elevated levels of glucocorticoids plays a role in the dysregulation of the hypothalamic–pituitary–adrenal axis and potentially learning and memory by altering the expression of specific genes within the amygdala and PVN.
Influence of Rheological Properties of Lithium Greases on Operating Behavior in Oscillating Rolling Bearings at a Small Swivel Angle
Authors: Slabka Iryna , Henniger Sören , Kücükkaya David , Dawoud Michael , Schwarze Hubert
Published: July 2022

In this study, the behavior of greases during oscillating bearing operation with a small oscillation angle and high frequency was investigated. This mode of operation entails demands on the lubrication system that differ significantly from those for continuously rotating bearings. In order to determine the variables influencing the suitability of a lubricating grease for small angle oscillating operation, the grease samples were examined with particular regard to their rheological properties. The focus of this investigation was to find a relationship between the rheological parameters and the real behavior in the bearing. Therefore, rheological and physical parameters, which influence the long-term structural changes and lubrication conditions, were identified. For this purpose, the viscosity was measured over a wide shear-rate range. The storage and loss modulus, the work of deformation, and the adhesion force jump are also determined. Afterward, rotational transient flow measurements were performed. These allowed us to analyze the development of the shear stress over time, at a constant shear rate, and to examine the internal friction behavior by evaluating the energy density. Subsequently, grease-lubricated four-point bearings were used in component tests, while the frictional torque was measured. These bearings operated in oscillating motion. Moreover, the yield point of mechanically aged greases was measured and compared with that of fresh greases to examine the influence of the oscillating operation on the lubricant condition. Finally, correlations between grease composition, rheological measurements, and component tests were investigated. Thereby, parameters influencing the frictional behavior of greases in rolling bearings during oscillating operation at small swivel angles were identified.
Stretchable and Conductive Cellulose/Conductive Polymer Composite Films for On-Skin Strain Sensors
Authors: Han Joo Won , Park Jihyun , Kim Jung Ha , Entifar Siti Aisyah Nurmaulia , Prameswati Ajeng , Wibowo Anky Fitrian , Kim Soyeon , Lim Dong Chan , Lee Jonghee , Moon Myoung-Woon , Kim Min-Seok , Kim Yong Hyun
Published: July 2022

Conductive composite materials have attracted considerable interest of researchers for application in stretchable sensors for wearable health monitoring. In this study, highly stretchable and conductive composite films based on carboxymethyl cellulose (CMC)-poly (3,4-ethylenedioxythiopehe):poly (styrenesulfonate) (PEDOT:PSS) (CMC-PEDOT:PSS) were fabricated. The composite films achieved excellent electrical and mechanical properties by optimizing the lab-synthesized PEDOT:PSS, dimethyl sulfoxide, and glycerol content in the CMC matrix. The optimized composite film exhibited a small increase of only 1.25-fold in relative resistance under 100% strain. The CMC-PEDOT:PSS composite film exhibited outstanding mechanical properties under cyclic tape attachment/detachment, bending, and stretching/releasing tests. The small changes in the relative resistance of the films under mechanical deformation indicated excellent electrical contacts between the conductive PEDOT:PSS in the CMC matrix, and strong bonding strength between CMC and PEDOT:PSS. We fabricated highly stretchable and conformable on-skin sensors based on conductive and stretchable CMC-PEDOT:PSS composite films, which can sensitively monitor subtle bio-signals and human motions such as respiratory humidity, drinking water, speaking, skin touching, skin wrinkling, and finger bending. Because of the outstanding electrical properties of the films, the on-skin sensors can operate with a low power consumption of only a few microwatts. Our approach paves the way for the realization of low-power-consumption stretchable electronics using highly stretchable CMC-PEDOT:PSS composite films.
One-Temperature Analytical Model for Femto-/Atto-Second Laser–Metals Drilling: A Novel Approach
Authors: Mihailescu Cristian N. , Mahmood Muhammad Arif , Mihailescu Natalia , Oane Mihai
Published: July 2022

Recently, ultrafast lasers have been developed and potentially become a point of interest worldwide, as their interaction with matter is yet unknown and can be mediated by new physical mechanisms. Real-time experimentation requires enormous costs, and there is therefore a need to develop computational models for this domain. By keeping in view this idea, a non-Fourier heat equation has solved the case of ultrafast laser–material interaction. Initial and boundary conditions were considered, and a one-dimensional mathematical model was presented. The simulations were compared with the experimental results for ultrashort laser–metallic sample interaction, and a close correlation was proven. It was found that the coupling of electron–phonon becomes “zero” due to short laser–material interaction time. The propagation of thermal waves was identified due to non-Fourier heat implementation. When the pulse duration increases, the variation in the thermal distribution becomes trivial due to an inverse correlation between the pulse duration and total energy within the pulse. When the laser–material interaction time decreases from fs to as, the generation of thermal waves increases and the powerful laser intensity acts as a shock wave during laser–material interaction, which causes a higher intensity of the thermal wave.
Investigation of Bamboo Fibrous Tensile Strength Using Modified Weibull Distribution
Authors: Dessalegn Yalew , Singh Balkeshwar , Vuure Aart W. van , Badruddin Irfan Anjum , Beri Habtamu , Hussien Mohamed , Ahmed Gulam Mohammed Sayeed , Hossain Nazia
Published: July 2022

Ethiopia has a large coverage of bamboo plants that are used for furniture making and house building. So far, researchers have not studied the strength of Ethiopian bamboo fibers, which are utilized for composite applications. The current study measured the strength of bamboo fibers based on various testing lengths and calculated the predictive tensile strength using a modified Weibull distribution. Moreover, the quality of the extraction machine is evaluated based on shape and sensitivity parameters. This research paper incorporates the coefficient of variation of the fiber diameters, considering the defects distribution through the length for measuring the predictive strength of the fibers. The fiber diameters were calculated using the area weight methods, which had its density measured using a Pycnometer. It has been examined that as the testing gauge length and coefficient variation of fiber diameter simultaneously increased, the tensile strength of the bamboo fibers decreased. The shape parameter, sensitivity parameter, and characteristic strength of Injibara bamboo (Y. alpina) are 6.02–7.83, 0.63, and 459–642 MPa, whereas Kombolcha bamboo (B. oldhamii) are 5.87–10.21, 0.33, and 408–638 MPa, as well as Mekaneselam bamboo (Y. alpina) are 5.86–9.63, 0.33 and 488–597 MPa, respectively.
On Proof-of-Accuracy Consensus Protocols
Authors: Aponte-Novoa Fredy Andres , Villanueva-Polanco Ricardo
Published: July 2022

Consensus protocols are a fundamental part of any blockchain; although several protocols have been in operation for several years, they still have drawbacks. For instance, some may be susceptible to a 51% attack, also known as a majority attack, which may suppose a high risk to the trustworthiness of the blockchains. Although this attack is theoretically possible, executing it in practice is often regarded as arduous because of the premise that, with sufficiently active members, it is not ’straightforward’ to have much computing power. Since it represents a possible vulnerability, the community has made efforts to solve this and other blockchain problems, which has resulted in the birth of alternative consensus protocols, e.g., the proof of accuracy protocol. This paper presents a detailed proposal of a proof-of-accuracy protocol. It aims to democratize the miners’ participation within a blockchain, control the miners’ computing power, and mitigate the majority attacks.
Modular Geometric Properties in Variable Exponent Spaces
Authors: Khamsi Mohamed A. , Méndez Osvaldo D. , Reich Simeon
Published: July 2022

Much has been written on variable exponent spaces in recent years. Most of the literature deals with the normed space structure of such spaces. However, because of the variability of the exponent, the underlying modular structure of these spaces is radically different from that induced by the norm. In this article, we focus our attention on the progress made toward the study of the modular structure of the sequence Lebesgue spaces of variable exponents. In particular, we present a survey of the state of the art regarding modular geometric properties in variable exponent spaces.
Epithelioid Rhabdomyosarcoma at the High Parietal Area of the Head: A Case Report
Authors: Jung Susanne , Bohner Lauren , Schulte Miriam , Kleinheinz Johannes
Published: July 2022

Epithelioid rhabdomyosarcoma is a rare condition, which may be clinically misinterpreted as melanoma due to its morphological appearance. Careful morphological and immunohistochemical analysis play an important role in its diagnosis. This case report describes the clinicopathological features of an epithelioid RMS diagnosed at the high parietal area of the head. A 71-year-old male patient presented a red-brown pigmented ulcerative nodule in the high parietal region of the head. Previous biopsy and computer tomography imaging revealed a malignant melanoma in stage I (pT2, sN0, Mx). After tumor operation, histological and immunohistochemical analysis of the tumor were conducted. Histological analysis showed an erosive lesion with a monomorphic cell population containing small cells with prominent nucleoli. A positivity was confirmed for CD10, Vimentin, and Desmin. MyoD1 was detected, as well as a fluctuating signal for p53. Molecular analysis revealed a negativity for Sox-10, and a weak positivity for CK8/18 by absence of p40. Based on the morphological and immunohistochemical findings, the tumor was diagnosed as epithelioid RMS.
Electrospun Hydrophobic Interaction Chromatography (HIC) Membranes for Protein Purification
Authors: Chen Shu-Ting , Wickramasinghe Sumith Ranil , Qian Xianghong
Published: July 2022

Responsive membranes for hydrophobic interaction chromatography have been fabricated by functionalizing poly(N-vinylcaprolactam) (PVCL) ligands on the substrate of electrospun regenerated cellulose nanofibers. Both static and dynamic binding capacities and product recovery were investigated using bovine serum albumin (BSA) and Immunoglobulin G (IgG) as model proteins. The effects of ligand chain length and chain density on static binding capacity were also studied. A static binding capacity of ~25 mg/mL of membrane volume (MV) can be achieved in optimal ligand grafting conditions. For dynamic binding studies, protein binding capacity increased with protein concentration from 0.1 to 1.0 g/L. Dynamic binding capacity increased from ~8 mg/mL MV at 0.1 g/L BSA to over 30 mg/mL at 1.0 g/L BSA. However, BSA recovery decreased as protein concentration increased from ~98% at 0.1 g/L BSA to 51% at 1 g/L BSA loading concentration. There is a clear trade-off between binding capacity and recovery rate. The electrospun substrate with thicker fibers and more open pore structures is superior to thinner fibrous membrane substrates.
Study on the Effects of Multiple Laser Shock Peening Treatments on the Electrochemical Corrosion Performance of Welded 316L Stainless Steel Joints
Authors: Li Yuqin , Fan Jinyu , Wen Jianzhong , Nie Xiangfan , Zhou Liucheng
Published: July 2022

To study the influence of laser shock peening on the electrochemical corrosion resistance of welded 316L stainless steel joints, welded 316L stainless steel joints are treated with different laser shock peening treatments (i.e., one, two, and three times). Our analysis employs electron backscattering diffraction (EBSD), scanning electron microscopy (SEM), X-ray diffraction (XRD), an X-ray stress meter, and electrochemical corrosion tests to observe and analyze the microstructure, structural composition, residual stress, and corrosion resistance in different areas of the surface of 316L before and after the laser shock peening. The results show that the residual stress distribution of the welded joints is optimized after laser shock peening, with a maximum residual compressive stress near the matrix of 171 MPa. When the number of laser shock peening treatments is two, the corrosion current reaches a minimum of 9.684×10−7 A/cm2, and optimal pitting resistance is obtained. However, when the number of laser shock peening treatments is further increased to three, the corrosion current increase and the pitting resistance decreases. In summary, the electrochemical corrosion resistance of the welded joints effectively improves after laser shock peening, but its performance begins to decline after three repeated shocks, which is related to the combined effects of stress change and microstructure phase transformation.