bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Modeling and Robust Controllers Design for Doubly Fed Induction Generator-Based Wind Turbines under Unbalanced Grid Fault Conditions
Authors: Khan Imran , Zeb Kamran , Din Waqar Ud , Islam Saif Ul , Ishfaq Muhammad , Hussain Sadam , Kim Hee-Je
Published: February 2019

High penetration of large capacity wind turbines into power grid has led to serious concern about its influence on the dynamic behaviors of the power system. Unbalanced grid voltage causing DC-voltage fluctuations and DC-link capacitor large harmonic current which results in degrading reliability and lifespan of capacitor used in voltage source converter. Furthermore, due to magnetic saturation in the generator and non-linear loads distorted active and reactive power delivered to the grid, violating grid code. This paper provides a detailed investigation of dynamic behavior and transient characteristics of Doubly Fed Induction Generator (DFIG) during grid faults and voltage sags. It also presents novel grid side controllers, Adaptive Proportional Integral Controller (API) and Proportional Resonant with Resonant Harmonic Compensator (PR+RHC) which eliminate the negative impact of unbalanced grid voltage on the DC-capacitor as well as achieving harmonic filtering by compensating harmonics which improve power quality. Proposed algorithm focuses on mitigation of harmonic currents and voltage fluctuation in DC-capacitor making capacitor more reliable under transient grid conditions as well as distorted active and reactive power delivered to the electric grid. MATLAB/Simulink simulation of 2 MW DFIG model with 1150 V DC-linked voltage has been considered for validating the effectiveness of proposed control algorithms. The proposed controllers performance authenticates robust, ripples free, and fault-tolerant capability. In addition, performance indices and Total Harmonic Distortions (THD) are also calculated to verify the robustness of the designed controller.
Analysis of the Flow Field from Connection Cones to Monolith Reactors
Authors: Mu Mingfei , Sjöblom Jonas , Ström Henrik , Li Xinghu
Published: February 2019

The connection cones between an exhaust pipe and an exhaust after-treatment system (EATS) will affect the flow into the first monolith. In this study, a new streamlined connection cone using non-uniform rational B-splines (NURBS) is applied to optimize the flow uniformity inside two different monoliths (a gasoline particulate filter and an un-coated monolith). NURBS and conventional cones were created using 3D printing with two different cone angles. The velocities after the monolith were collected to present the uniformity of the flows under different cones and different velocities. The test results indicate that NURBS cones exhibit better performance. Furthermore, all of the pressure drops of the bench test were measured and compared with those of the conventional cones, demonstrating that the NURBS cones can reduce the pressure drop by up to 12%. The computer fluid dynamics simulations depict detailed changes in the flow before and after entering the monolith. The results show that the NURBS cone avoids the generation of a recirculating zone associated with conventional cones and creates a more uniform flow, which causes a lower pressure drop. Meanwhile, the package structure of the NURBS cone can reduce the space requirements. Finally, the implications of the flow distributions are discussed.
Research on Coal Pillar Malposition Distance Based on Coupling Control of Three-Field in Shallow Buried Closely Spaced Multi-Seam Mining, China
Authors: Huang Qingxiang , Cao Jian
Published: February 2019

In order to explore the rational coal pillar malposition distance (CPMD) based on coupling control of stress field, displacement field and fracture field (three-field) in shallow buried closely spaced multi-seam (SBCSM-S) mining, and realize coupling control of underground concentrated stress and ground surface fractures, taking the No. 1–2 and No. 2–2 coal seams mining in the northward east area of Ningtiaota coal mine as background, through physical simulation and theoretical analysis, the three-field evolution in SBCSM-S mining was analysed, the effect of different CPMD on coal pillar concentrated stress, ground surface subsidence and fractures development was revealed, and the rational CPMD based on coupling control of three-field was put forward. The results show that the concentrated fractures and concentrated stress are due to the strata’s uneven subsidence by coal pillars. Rational arrangement of CPMD can avoid the superposition of vertical stress caused by upper and lower coal pillars and reduce the development of ground fractures and uneven subsidence. Two theoretical models were established: one was based on the control of a concentrated stress field, the other on the control of the displacement and fracture fields. These results will be applied in a follow-up arrangement at the Ningtiaota coal mine, and can provide a new way for safe and green mining in SBCSM-S.
Preventive Effect of Blueberry Extract on Liver Injury Induced by Carbon Tetrachloride in Mice
Authors: Liu Bihui , Fang Yuan , Yi Ruokun , Zhao Xin
Published: February 2019

The blueberry is a common fruit that is rich in nutritional value and polyphenol substances. In this study, the blueberry polyphenol content in extract was analysed by spectrophotometry. The results showed that the blueberry polyphenol content in the extract reached 52.7%. A mouse model of liver injury induced by carbon tetrachloride (CCl4) was established to study the preventive effect of blueberry extract (BE) on liver injury in mice and the experimental animals were examined using biochemical and molecular biological methods. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are important clinical liver function indicators; the changes of triglyceride (TG) and total cholesterol (TC) are observed after liver injury; interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) are important inflammatory indexes; superoxide dismutase (SOD) activity and thiobarbituric acid reactive substances (TBARS) are important changes of oxidative stress indexes. The in vivo animal experiment results showed that BE decreased the liver index of mice with liver injury, BE could reduce the AST, ALT, TG and TC levels and also could reduce the serum cytokine IL-6, TNF-α and IFN-γ levels in mice with liver injury. Moreover, BE increased the SOD activity and decreased the TBARS level in the gastric tissues of mice with liver injury. After treatment with the highest concentration of BP in liver injury mice, these levels returned close to those obtained after treatment with the standard drug of silymarin. Detection of messenger RNA (mRNA) in liver tissue showed that BE upregulated the Cu/Zn-SOD, Mn-SOD and chloramphenicol acetyltransferase (CAT) expression levels and downregulated cyclooxygenase (COX)-2 expression. The effect of BE on mice with liver injury was positively correlated with the BE concentration and was similar to that of silymarin, which is a drug for liver injury, suggesting that BE had a good preventive effect on liver injury. Thus, BE rich in polyphenols is a bioactive substance with value for development and utilization.
Critical Review on the Utilization of Handheld and Portable Raman Spectrometry in Meat Science
Authors: Beganović Anel , Hawthorne Luzia Maria , Bach Katrin , Huck Christian W.
Published: February 2019

Traditional methods for the determination of meat quality-relevant parameters are rather time-consuming and destructive, whereas spectroscopic methods offer fast and non-invasive measurements. This review critically deals with the application of handheld and portable Raman devices in the meat sector. Some published articles on this topic tend to convey the impression of unrestricted applicability of mentioned devices in this field of research. Furthermore, results are often subjected to over-optimistic interpretations without being underpinned by adequate test set validation. On the other hand, deviations in reference methods for meat quality assessment and the inhomogeneity of the meat matrix pose a challange to Raman spectroscopy and multivariate models. Nonetheless, handheld and portable Raman devices show considerable potential for some applications in the meat sector.
Variation of Adolescent Snack Food Choices and Preferences along a Continuum of Processing Levels: The Case of Apples
Authors: Svisco Elizabeth , Byker Shanks Carmen , Ahmed Selena , Bark Katie
Published: February 2019

Food processing is used for transforming whole food ingredients into food commodities or edible products. The level of food processing occurs along a continuum from unprocessed to minimally processed, processed, and ultra-processed. Unprocessed foods use little to no processing and have zero additives. Minimally processed foods use finite processing techniques, including drying, freezing, etc., to make whole food ingredients more edible. Processed foods combine culinary ingredients with whole foods using processing and preservation techniques. Ultra-processed foods are manufactured using limited whole food ingredients and a large number of additives. Ultra-processed snack foods are increasing in food environments globally with detrimental implications for human health. This research characterizes the choices, consumption, and taste preferences of adolescents who were offered apple snack food items that varied along a processing level continuum (unprocessed, minimally processed, processed, and ultra-processed). A cross-sectional study was implemented in four elementary school classrooms utilizing a buffet of apple snack food items from the aforementioned four food processing categories. A survey was administered to measure students’ taste acceptance of the snacks. The study found that the students selected significantly (p < 0.0001) greater quantities of ultra-processed snack foods (M = 2.20 servings, SD = 1.23) compared to minimally processed (M = 0.56 servings, SD = 0.43) and unprocessed (M = 0.70 servings, SD = 0.37) snack foods. The students enjoyed the taste of ultra-processed snack foods (M = 2.72, SD = 0.66) significantly more (p < 0.0001) than minimally processed (M = 1.92, SD = 1.0) and unprocessed (M = 2.32, SD = 0.9) snack foods. A linear relationship was found between the selection and consumption quantities for each snack food item (R2 = 0.88). In conclusion, it was found that as processing levels increase in apple snack foods, they become more appealing and more heavily consumed by elementary school students. If applied broadly to snack foods, this conclusion presents one possible explanation regarding the high level of diet-related diseases and nutrient deficiencies across adolescents in America. Food and nutrition education, food product development, and marketing efforts are called upon to improve adolescent food choices and make less-processed snack food options more appealing and accessible to diverse consumers.
Single and Double Strand Sperm DNA Damage: Different Reproductive Effects on Male Fertility
Authors: Ribas-Maynou Jordi , Benet Jordi
Published: February 2019

Reproductive diseases have become a growing worldwide problem and male factor plays an important role in the reproductive diagnosis, prognosis and design of assisted reproductive treatments. Sperm cell holds the mission of carrying the paternal genetic complement to the oocyte in order to contribute to an euploid zygote with proper DNA integrity. Sperm DNA fragmentation had been used for decades as a male fertility test, however, its usefulness have arisen multiple debates, especially around Intracytoplasmic Sperm Injection (ICSI) treatments. In the recent years, it has been described that different types of sperm DNA breaks (single and double strand DNA breaks) cause different clinical reproductive effects. On one hand, single-strand DNA breaks are present extensively as a multiple break points in all regions of the genome, are related to oxidative stress and cause a lack of clinical pregnancy or an increase of the conception time. On the other hand, double-strand DNA breaks are mainly localized and attached to the sperm nuclear matrix as a very few break points, are possibly related to a lack of DNA repair in meiosis and cause a higher risk of miscarriage, low embryo quality and higher risk of implantation failure in ICSI cycles. The present work also reviews different studies that may contribute in the understanding of sperm chromatin as well as treatments to prevent sperm DNA damage.
The Mitochondrial Genomes of Neuropteridan Insects and Implications for the Phylogeny of Neuroptera
Authors: Song Nan , Li Xin-Xin , Zhai Qing , Bozdoğan Hakan , Yin Xin-Ming
Published: February 2019

The higher-level phylogeny of Neuroptera is explored here based on the newly determined mitochondrial genomic data, with a special focus on the interfamilial relationships of this group. Despite considerable progress in our understanding of neuropteran relationships, several mutually exclusive hypotheses have come out according to morphology-based analyses and molecular sequence data. The evaluation of these hypotheses is hampered by the limited taxonomic coverage of previous studies. In this paper, we sequenced four mitochondrial genomes to improve the taxonomic sampling for families: Myrmeleontidae, Ascalaphidae and outgroup Corydalidae. Phylogenetic analyses were run using various inference methods to (1) confirm that Coniopterygidae is sister to all other Neuroptera; (2) place Hemerobiidae as sister to Chrysopidae; (3) support the monophyly of Myrmeleontiformia and define its interfamilial relationships; and (4) recover Myrmeleontidae as paraphyletic due to the nested Ascalaphidae.
From Maps to Stories: Dangerous Spaces in Agatha Christie’s Homes
Authors: Sarnelli Debora A.
Published: February 2019

In the common imagination, home denotes the physical space where human beings find protection, intimacy, and bliss. Home is a place of affection and warmth. This article proposes to analyze the perception of the place called home within Christie’s narratives and how her fictional households are deprived of their protective value and become as blood soaked as the hard-boiled dirty back alleys. The article focuses on how every room occupies a different role in Christie’s fictional houses. There are safe rooms—the busiest rooms of the household where murder never happens—and dangerous rooms. The dangerous room—the murder scene—is described through the use of a map offered by the first-person narrator. The map provides the reader with important spatial information: this is the very place where the murder was perpetrated.
Nubia Still Exists: On the Utility of the Nostalgic Space
Authors: Agha Menna
Published: February 2019

The Egyptian government displaced all Nubian villages to build the High Dam. New generations of Egyptian Nubians still identify as displaced and live in a nostalgic virtual space that carries a rendition of a paradise-like old Nubia. I investigate this spatial phenomenon by surveying Nubian literary and oral tradition, which displays signs of belonging to a geography that is no longer material. This paper lays out a conceptualisation of this space of nostalgia perpetuated in a metanarrative of a utopian lost land, that poses it as a disembodied territory while nostalgia is territoriality. From my position as a Nubian woman and a scholar, I use auto-ethnographic tools to methodically decode and layout this territory. The paper offers empirical evidence of the effect of these virtual territories on materialised spatial production and, therefore, argues that Nubians remain space makers by carving their own virtual territory and that Nubia still exists.
Evaluation of Two Wild Populations of Hedge Mustard (Sisymbrium officinale (L.) Scop.) as a Potential Leafy Vegetable
Authors: Guarise Marta , Borgonovo Gigliola , Bassoli Angela , Ferrante Antonio
Published: February 2019

The minimally processed industry is always looking for produce innovation that can satisfy consumer needs. Wild leafy vegetables can be a good source of bioactive compounds and can be attractive for the consumer in term of visual appearance and taste. In this work, Sisymbrium officinale (L.) Scop., commonly called hedge mustard, was grown in a greenhouse and evaluated as a potential leafy vegetable. Two wild populations, Milano (MI) and Bergamo (BG), were grown in peat substrate and harvested at the commercial stage for the minimally processing industry. Leaf pigments such as chlorophyll and carotenoids were determined as well as chlorophyll a fluorescence parameters. Total sugars, antioxidant compounds such as ascorbic acid, phenolic index, total phenols, anthocyanins, and nitrate were determined at harvest. Significant differences between wild populations were found in April with higher nitrate content in BG, 2865 mg/kg FW than in MI, 1770 mg/kg FW. The nitrate levels of S. officinale measured in the present study are significantly lower than the maximum NO₃ level allowed in other fresh leafy vegetables. Ascorbic acid measured in November was higher in MI compared BG with values of 54.4 versus 34.6 mg/100 g FW, respectively. The chlorophyll a fluorescence data showed that BG reached optimal leaf functionality faster than MI. Overall results indicated that Sisymbrium officinale (L.) Scop. can be suggested as a potential leafy vegetable for the minimally processed industry.
Explicit Characterization of Spatial Heterogeneity Based on Water Quality, Sediment Contamination, and Ichthyofauna in a Riverine-to-Coastal Zone
Authors: Kim Dong-Kyun , Jo Hyunbin , Han Inwoo , Kwak Ihn-Sil
Published: February 2019

Our study aims to identify the spatial characteristics of water quality and sediment conditions in relation to fisheries resources, since the productivity of fisheries resources is closely related to the ambient conditions of the resource areas. We collected water quality samples and sediment contaminants from twenty-one sites at Gwangyang Bay, Korea, in the summer of 2018. Our study sites covered the area from the Seomjin River estuary to the inner and outer bays. To spatially characterize physicochemical features of Gwangyang Bay, we used Self-Organizing Map (SOM), which is known as a robust and powerful tool of unsupervised neural networks for pattern recognition. The present environmental conditions of Gwangyang Bay were spatially characterized according to four different attributes of water quality and sediment contamination. From the results, we put emphasis on several interesting points: (i) the SOM manifests the dominant physicochemical attributes of each geographical zone associated with the patterns of water quality and sediment contamination; (ii) fish populations appear to be closely associated with their food sources (e.g., shrimps and crabs) as well as the ambient physicochemical conditions; and (iii) in the context of public health and ecosystem services, the SOM result can potentially offer guidance for fish consumption associated with sediment heavy metal contamination. The present study may have limitations in representing general features of Gwangyang Bay, given the inability of snapshot data to characterize a complex ecosystem. In this regard, consistent sampling and investigation are needed to capture spatial variation and to delineate the temporal dynamics of water quality, sediment contamination, and fish populations. However, the SOM application is helpful and useful as a first approximation of an environmental assessment for the effective management of fisheries resources.
Prevalence of Depression and Anxiety in Colorectal Cancer Patients: A Literature Review
Authors: Peng Yu-Ning , Huang Mei-Li , Kao Chia-Hung
Published: February 2019

Background: We aimed to review published studies to obtain the best estimate of the risk of depression and anxiety among colorectal cancer (CRC) patients. Methods: We searched the PubMed/Medline database, Web of Science, and Google Scholar on the prevalence of depression or anxiety in CRC patients. A review of 15 studies published between June 1967 and June 2018 were conducted, and 93,805 CRC patients were included. Results: The prevalence of depression among patients diagnosed with CRC ranged from 1.6%–57%, and those of anxiety ranged from 1.0%–47.2%. Studies in which an expert (psychiatrist) administered the interviews reported lower prevalence of both depression and anxiety. Conclusion: The findings of this review suggest that patients with CRC exhibited a significantly high prevalence of both depression and anxiety, and these symptoms can persist even after cancer treatment is completed. However, the correlation of age and the emergence of depression or anxiety in CRC patients still remain controversial.
Medication Event Monitoring System for Infectious Tuberculosis Treatment in Morocco: A Retrospective Cohort Study
Authors: Park Seup , Sentissi Ilham , Gil Seung Jae , Park Won-Seok , Oh ByungKwon , Son Ah Reum , Kong Young Ju , Park Sol , Paek Eunseong , Park Yong Joon , Lee Seung Heon
Published: February 2019

Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13–8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05–0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.
Effects of Demographic Variables on Subjective Neurocognitive Complaints Using the Neurocognitive Questionnaire (NCQ) in an Aged Japanese Population
Authors: Yamada Michiko , Landes Reid , Hida Ayumi , Ishihara Kayoko , Krull Kevin
Published: February 2019

Objectives: In an aged Japanese population, we investigated associations of demographic variables with subjective neurocognitive complaints using the Neurocognitive Questionnaire (NCQ). Methods: Participants (N = 649) provided answers to the NCQ in both 2011 and 2013. Using fully-completed NCQs from 503 participants in 2011, we identified latent factors of subjective neurocognitive complaints using exploratory factor analysis; then examined associations of demographic variables with the identified factors for all 649 participants over the two years. We also examined changes in factor scores over the 2-year period. Results: We identified four factors representing 20 of the 25 NCQ items and labelled them metacognition, emotional regulation, motivation/organization, and processing speed. In a regression model using all participants, we observed linear deterioration with age on emotional regulation and linear-quadratic deterioration with age on the other factors. Less education was associated with more problems for all factors, but we detected no evidence of interaction between age and education. In 314 participants completing both assessments, paired t-tests comparing the 2013 to 2011 responses corroborated the regression results, except for emotional regulation. Conclusions: On the NCQ, older age and less education were associated with more subjective neurocognitive complaints. This is compatible with the association of the same factors with objective cognition and suggests that subjective cognitive complaints complement objective cognition as a prodrome of non-normative cognitive decline.
A Mass Transfer Analysis of Competitive Binding of Pb, Cd, and Zn from Binary Systems onto a Fixed Zeolite Bed
Authors: Nuić Ivona , Trgo Marina , Vukojević Medvidović Nediljka , Ugrina Marin
Published: February 2019

The low-cost natural zeolite clinoptilolite was successfully applied for the competitive removal of Pb, Cd, and Zn from binary (Pb + Zn) and (Cd + Zn) aqueous solutions at different Pb/Zn and Cd/Zn concentration ratios. The obtained efficiency was in the range of 79.0–85.0%, and was similar for both systems, indicating that no loss in capacity was observed for six successive sorption-desorption cycles. In both systems, after the breakthrough, competition between the ions occurs, leading to overshooting in the Zn’s initial concentration, indicating displacement of already-bound Zn with Pb and Cd from the feeding solutions. The Zn exceeded its initial concentration up to 2.3 times in the presence of Pb, and up to 1.2 times in the presence of Cd. The film diffusion was pronounced as the slowest step responsible for the overall process rate. The overall mass transfer coefficient (Ka) shows higher values for the (Cd + Zn) system compared to the (Pb + Zn) one due to reduced competition and ions migration. An SEM-EDS analysis confirmed a higher amount of bound Pb and Cd compared to Zn, and a mapping analysis revealed the equal distribution of all ions onto the zeolite surface.
Depression and Sleep
Authors: Steiger Axel , Pawlowski Marcel
Published: February 2019

Impaired sleep is both a risk factor and a symptom of depression. Objective sleep is assessed using the sleep electroencephalogram (EEG). Characteristic sleep-EEG changes in patients with depression include disinhibition of rapid eye movement (REM) sleep, changes of sleep continuity, and impaired non-REM sleep. Most antidepressants suppress REM sleep both in healthy volunteers and depressed patients. Various sleep-EEG variables may be suitable as biomarkers for diagnosis, prognosis, and prediction of therapy response in depression. In family studies of depression, enhanced REM density, a measure for frequency of rapid eye movements, is characteristic for an endophenotype. Cordance is an EEG measure distinctly correlated with regional brain perfusion. Prefrontal theta cordance, derived from REM sleep, appears to be a biomarker of antidepressant treatment response. Some predictive sleep-EEG markers of depression appear to be related to hypothalamo-pituitary-adrenocortical system activity.
Characterization of SIRT1/DNMTs Functions and LINE-1 Methylation in Patients with Age-Related Macular Degeneration
Authors: Maugeri Andrea , Barchitta Martina , Fallico Matteo , Castellino Niccolò , Reibaldi Michele , Agodi Antonella
Published: February 2019

Previous studies proposed the application of DNA methylation signatures as clinical biomarkers of age-related macular degeneration (AMD). However, the characterization of Long Interspersed Nuclear Element-1 (LINE-1) methylation levels—a surrogate marker of global DNA methylation—in AMD patients has not been investigated so far. In the present study, we first characterized DNA methyltransferases (DNMTs) and Sirtuin 1 (SIRT1) functions in blood samples of 40 AMD patients and 10 age- and sex-matched controls. Then, we evaluated whether changes in DNMTs functions were associated with different LINE-1 methylation levels in leukocyte DNA. We demonstrated that total DNMTs activity was 48% higher in AMD patients than in controls (p = 0.005). AMD patients also exhibited up-regulation of DNMT1 and DNMT3B expression (FC = 2.6; p = 0.003 and FC = 2.4; p = 0.018, respectively). In line with increased DNMTs functions, the LINE-1 methylation level was higher in AMD patients than in controls (mean = 69.10%; SE = 0.68 vs. mean = 65.73%; SE = 0.59; p = 0.020). All p-values were adjusted by Bonferroni correction. In AMD patients, LINE-1 methylation level was positively associated with total DNMTs activity (r = 0.694; p < 0.001), DNMT1 (r = 0.579; p < 0.001), and DNMT3B (r = 0.521; p = 0.001) expression. Our results encourage further large-size prospective research to understand the relationship between LINE-1 methylation and AMD aetiology, and its usefulness in the clinical setting.
Gender-Related Patterns of Emotion Regulation among Patients with Eating Disorders
Authors: Agüera Zaida , Paslakis Georgios , Munguía Lucero , Sánchez Isabel , Granero Roser , Sánchez-González Jessica , Steward Trevor , Jiménez-Murcia Susana , Fernández-Aranda Fernando
Published: February 2019

Difficulties in emotion regulation (ER) are common in females with eating disorders (ED). However, no study to date has analyzed ER in males with ED. In the study at hand, we assessed ER in males with ED and compared results to both females with ED and healthy controls (HC). We also examined associations between ER difficulties, personality, and psychopathology. A total of 62 males with ED were compared with 656 females with ED, as well as 78 male and 286 female HC. ER was assessed by means of the Difficulties in Emotion Regulation Scale (DERS). We found that males and females with ED showed greater ER difficulties compared to HC. Pronounced general psychopathology was a shared factor associated with higher ER difficulties in both males and females with ED. However, whereas higher novelty seeking, higher cooperativeness, lower reward dependence, and lower self-directedness were related to higher ER difficulties in females with ED, lower persistence was associated with ER difficulties in males with ED. In sum, males and females with ED show similar ER difficulties, yet they are distinct in how ER deficits relate to specific personality traits. Research on strategies promoting ER in the treatment of males with ED is warranted.
Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis
Authors: Kocovski Pece , Jiang Xiangrui , D’Souza Claretta S. , Li Zhenjiang , Dang Phuc T. , Wang Xiaowei , Chen Weisan , Peter Karlheinz , Hale Matthew W. , Orian Jacqueline M.
Published: February 2019

The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased anxiety-like behavior in experimental autoimmune encephalomyelitis (EAE), an accepted MS model. Due to the recently described critical role of platelets in inflammation and autoimmune disease, we examined the relationship between platelets, inflammation, and anxiety-like behavior in EAE. In the elevated plus maze, EAE-induced C57BL/6J mice showed decreased time spent in the open arms relative to vehicle-only controls, demonstrating an increase in anxiety-like behavior. This effect occurred in the presence of platelet–neuron association, but absence of lymphocytic infiltration, in the hippocampal parenchyma. Platelet depletion at the pre-clinical disease stage, using antibody-mediated lysis prevented the EAE-induced increase in anxiety-like behavior, while no significant difference in distance moved was recorded. Furthermore, platelet depletion was also associated with reduction of the pro-inflammatory environment to control levels in the hippocampus and prevention of EAE disease symptomology. These studies demonstrate the high efficacy of a platelet-targeting approach in preventing anxiety-like symptoms and clinical manifestations of EAE and have implications for the treatment of neuropsychiatric symptoms in MS.
Artificial Intelligence vs. Natural Stupidity: Evaluating AI Readiness for the Vietnamese Medical Information System
Authors: Vuong Quan-Hoang , Ho Manh-Tung , Vuong Thu-Trang , La Viet-Phuong , Ho Manh-Toan , Nghiem Kien-Cuong P. , Tran Bach Xuan , Giang Hai-Ha , Giang Thu-Vu , Latkin Carl , Nguyen Hong-Kong T. , Ho Cyrus S.H. , Ho Roger C.M.
Published: February 2019

This review paper presents a framework to evaluate the artificial intelligence (AI) readiness for the healthcare sector in developing countries: a combination of adequate technical or technological expertise, financial sustainability, and socio-political commitment embedded in a healthy psycho-cultural context could bring about the smooth transitioning toward an AI-powered healthcare sector. Taking the Vietnamese healthcare sector as a case study, this paper attempts to clarify the negative and positive influencers. With only about 1500 publications about AI from 1998 to 2017 according to the latest Elsevier AI report, Vietnamese physicians are still capable of applying the state-of-the-art AI techniques in their research. However, a deeper look at the funding sources suggests a lack of socio-political commitment, hence the financial sustainability, to advance the field. The AI readiness in Vietnam’s healthcare also suffers from the unprepared information infrastructure—using text mining for the official annual reports from 2012 to 2016 of the Ministry of Health, the paper found that the frequency of the word “database” actually decreases from 2012 to 2016, and the word has a high probability to accompany words such as “lacking”, “standardizing”, “inefficient”, and “inaccurate.” Finally, manifestations of psycho-cultural elements such as the public’s mistaken views on AI or the non-transparent, inflexible and redundant of Vietnamese organizational structures can impede the transition to an AI-powered healthcare sector.
A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis
Authors: Chen Chih-Hao , Coyac Benjamin R. , Arioka Masaki , Leahy Brian , Tulu U. Serdar , Aghvami Maziar , Holst Stefan , Hoffmann Waldemar , Quarry Antony , Bahat Oded , Salmon Benjamin , Brunski John B. , Helms Jill A.
Published: February 2019

The preservation of bone viability at an osteotomy site is a critical variable for subsequent implant osseointegration. Recent biomechanical studies evaluating the consequences of site preparation led us to rethink the design of bone-cutting drills, especially those intended for implant site preparation. We present here a novel drill design that is designed to efficiently cut bone at a very low rotational velocity, obviating the need for irrigation as a coolant. The low-speed cutting produces little heat and, consequently, osteocyte viability is maintained. The lack of irrigation, coupled with the unique design of the cutting flutes, channels into the osteotomy autologous bone chips and osseous coagulum that have inherent osteogenic potential. Collectively, these features result in robust, new bone formation at rates significantly faster than those observed with conventional drilling protocols. These preclinical data have practical implications for the clinical preparation of osteotomies and alveolar bone reconstructive surgeries.
Carbon Fiber Reinforced Thermoplastics Molding by Using Direct Resistance Heating to Carbon Nanofilaments Grafted Carbon Fiber
Authors: Tanaka Kazuto , Habe Ririko , Tanaka Masayoshi , Katayama Tsutao
Published: February 2019

In the automobile industry, carbon fiber reinforced thermoplastics (CFRTP) have attracted attention as potential materials to reduce the weight of the automobile body. In order to apply CFRTP to mass-produced automobile parts, it is necessary to develop the reduction of molding time and the impregnation method into the carbon fiber (CF) for the thermoplastic resin, which has relatively high viscosity. Although the conventional hot press molding uses only the heat transfer from the mold to the molding materials, it is expected to develop a new molding method for CFRTP using heat generation of the materials themselves to overcome these issues. As a method of heating the carbon fiber, there is a direct resistance heating method, in which carbon fiber is directly energized and heated by Joule heat. We have developed resistance welding methods in which carbon nanotube (CNT) grafted carbon fiber (CNT-CF) is used for the heating elements, and revealed that the higher welded strength is obtained by using CNT-CF instead of CF. Therefore, the carbon nanofilaments (CNF) grafted carbon fiber (CNF-CF) including CNF-CF is expected not only to be used as a resistance heating medium at the time of joining but also as a reinforcing fiber and as a self-heating member at the time of molding. In this study, we develop the CFRTP molding method by using direct resistance heating to CNF-CF in the hot press molding. CFRTP ([0°]20) with the volume fractions (Vf) of 40% are molded by conventional hot press and hot press with direct resistance heating to reinforcing fiber. CF or CNF-CF is used for reinforcement. CFRTP molded by hot press with direct resistance heating to CNF-CF indicated lower void content than CFRTP molded by hot press with direct resistance heating to CF. Compared to CFRTP molding by only hot press, hot press molding with direct resistance heating to CNF-CF can mold CFRTP with low void content.
Bending, Free Vibration, and Buckling Analysis of Functionally Graded Porous Micro-Plates Using a General Third-Order Plate Theory
Authors: Coskun Semsi , Kim Jinseok , Toutanji Houssam
Published: February 2019

Static bending, free vibration and buckling of functionally graded porous micro-plates are investigated using a general third order plate theory. In addition, analytical solutions are obtained using the Navier method. The effect of the material length scale factor and the variation of material property through the thickness direction of plates are considered as well as porosity effects. Three different porosity distributions are considered and the effects of porosity variations are examined in the framework of a general third order plate theory. Numerical results show that the effect of each distribution of porosity is distinguished due to coupling between the heterogeneity of the material properties and the variation of porosity.
Role of Aspartic and Polyaspartic Acid on the Synthesis and Hydrolysis of Brushite
Authors: Rubini Katia , Boanini Elisa , Bigi Adriana
Published: February 2019

Dicalcium phosphate dihydrate (DCPD) is one of the mineral phases indicated as possible precursors of biological apatites and it is widely employed in the preparation of calcium phosphate bone cements. Herein, we investigated the possibility to functionalize DCPD with aspartic acid (ASP) and poly-aspartic acid (PASP), as models of the acidic macromolecules of biomineralized tissues, and studied their influence on DCPD hydrolysis. To this aim, the synthesis of DCPD was performed in aqueous solution in the presence of increasing concentrations of PASP and ASP, whereas the hydrolysis reaction was carried out in physiological solution up to three days. The results indicate that it is possible to prepare DCPD functionalized with PASP up to a polyelectrolyte content of about 2.3 wt%. The increase of PASP content induces crystal aggregation, reduction of the yield of the reaction and of the thermal stability of the synthesized DCPD. Moreover, DCPD samples functionalized with PASP display a slower hydrolysis than pure DCPD. On the other hand, in the explored range of concentrations (up to 10 mM) ASP is not incorporated into DCPD and does not influence its crystallization nor its hydrolysis. At variance, when present in the hydrolysis solution, ASP, and even more PASP, delays the conversion into the more stable phases, octacalcium phosphate and/or hydroxyapatite. The greater influence of PASP on the synthesis and hydrolysis of DCPD can be ascribed to the cooperative action of the carboxylate groups and to its good fit with DCPD structure.
Comparative Study on Local Binary Patterns for Mammographic Density and Risk Scoring
Authors: George Minu , Zwiggelaar Reyer
Published: February 2019

Breast density is considered to be one of the major risk factors in developing breast cancer. High breast density can also affect the accuracy of mammographic abnormality detection due to the breast tissue characteristics and patterns. We reviewed variants of local binary pattern descriptors to classify breast tissue which are widely used as texture descriptors for local feature extraction. In our study, we compared the classification results for the variants of local binary patterns such as classic LBP (Local Binary Pattern), ELBP (Elliptical Local Binary Pattern), Uniform ELBP, LDP (Local Directional Pattern) and M-ELBP (Mean-ELBP). A wider comparison with alternative texture analysis techniques was studied to investigate the potential of LBP variants in density classification. In addition, we investigated the effect on classification when using descriptors for the fibroglandular disk region and the whole breast region. We also studied the effect of the Region-of-Interest (ROI) size and location, the descriptor size, and the choice of classifier. The classification results were evaluated based on the MIAS database using a ten-run ten-fold cross validation approach. The experimental results showed that the Elliptical Local Binary Pattern descriptors and Local Directional Patterns extracted most relevant features for mammographic tissue classification indicating the relevance of directional filters. Similarly, the study showed that classification of features from ROIs of the fibroglandular disk region performed better than classification based on the whole breast region.
Developments in Electrical-Property Tomography Based on the Contrast-Source Inversion Method
Authors: Leijsen Reijer , Fuchs Patrick , Brink Wyger , Webb Andrew , Remis Rob
Published: February 2019

The main objective of electrical-property tomography (EPT) is to retrieve dielectric tissue parameters from B ^ 1 + data as measured by a magnetic-resonance (MR) scanner. This is a so-called hybrid inverse problem in which data are defined inside the reconstruction domain of interest. In this paper, we discuss recent and new developments in EPT based on the contrast-source inversion (CSI) method. After a short review of the basics of this method, two- and three-dimensional implementations of CSI–EPT are presented along with a very efficient variant of 2D CSI–EPT called first-order induced current EPT (foIC-EPT). Practical implementation issues that arise when applying the method to measured data are addressed as well, and the limitations of a two-dimensional approach are extensively discussed. Tissue-parameter reconstructions of an anatomically correct male head model illustrate the performance of two- and three-dimensional CSI–EPT. We show that 2D implementation only produces reliable reconstructions under very special circumstances, while accurate reconstructions can be obtained with 3D CSI–EPT.
Spatial and Temporal Variability of Dense Shelf Water Cascades along the Rottnest Continental Shelf in Southwest Australia
Authors: Mahjabin Tanziha , Pattiaratchi Charitha , Hetzel Yasha , Janekovic Ivica
Published: February 2019

Along the majority of Australian shallow coastal regions, summer evaporation increases the salinity of shallow waters, and subsequently in autumn/winter, the nearshore waters become cooler due to heat loss. This results in the formation of horizontal density gradients with density increasing toward the coast that generates gravity currents known as dense shelf water cascades (DSWCs) flowing offshore along the sea bed. DSWCs play important role in ecological and biogeochemical processes in Australian waters through the transport of dissolved and suspended materials offshore. In this study a numerical ocean circulation model of Rottnest continental shelf, validated using simultaneous ocean glider and mooring data, indicated that the passage of cold fronts associated with winter storms resulted in rapid heat loss through evaporative cooling. These conditions resulted in enhancement of the DSWCs due to modifications of the cross-shelf density gradient and wind effects. Specifically, onshore (offshore) directed winds resulted in an enhancement (inhibition) of DSWCs due to downwelling (vertical mixing). Consequently, the largest DSWC events occurred during the cold fronts when atmospheric temperatures reinforced density gradients and onshore winds promoted downwelling that enhanced DSWCs. Advection of DSWCs was also strongly influenced by the wind conditions, with significantly more transport occurring along-shelf compared to cross-shelf.
Refunctionalization. First-Person Plural of the Verb Haber in the History of Spanish
Authors: Hernández Díaz Axel
Published: February 2019

In this paper, the first-person plural diachronic behaviour of the verb form habemos with an existential value is analysed to explore its recovery in current Spanish as a case of refunctionalization. The latter is understood as timely cooptation of a form, which begins with any of the form’s characteristics. It is known that the cooptation’s origin might be directly, indirectly or not at all related to the previous or original use of the form. Results shown here are based on the analysis of constructions in which the first-person plural verb form of haber is used with a possessive meaning, as an auxiliary, and as existential between the 13th and 21st century. While grammaticalization theory pays attention to processes that culminate with grammatical enrichment of words or constructions, the verb form habemos with an existential meaning does not show that behaviour. It is explained as a case of refunctionalization or, at least, specialization.
Conductive Cellulose based Foam Formed 3D Shapes—From Innovation to Designed Prototype
Authors: Siljander Sanna , Keinänen Pasi , Ivanova Anastasia , Lehmonen Jani , Tuukkanen Sampo , Kanerva Mikko , Björkqvist Tomas
Published: February 2019

In this article, we introduce for the first time, a method to manufacture cellulose based electrically conductive non-woven three-dimensional (3D) structures using the foam forming technology. The manufacturing is carried out using a minimum amount of processing steps, materials, and hazardous chemicals. The optimized solution applies a single surfactant type and a single predefined portion for the two main processing steps: (1) the dispersing of nanocellulose (NC) and carbon nanotubes (CNT) and (2) the foam forming process. The final material system has a concentration of the used surfactant that is not only sufficient to form a stable and homogeneous nanoparticle dispersion, but it also results in stable foam in foam forming. In this way, the advantages of the foam forming process can be maximized for this application. The cellulose based composite material has a highly even distribution of CNTs over the NC network, resulting a conductivity level of 7.7 S/m, which increased to the value 8.0 S/m after surfactant removal by acetone washing. Also, the applicability and a design product case ‘Salmiakki’ were studied where the advantages of the material system were validated for a heating element application.
Microstructural and Mechanical Properties of Binary Ti-Rich Fe–Ti, Al-Rich Fe–Al, and Ti–Al Alloys
Authors: Chanbi Daoud , Adnane Amara Leïla , Ogam Erick , Amara Sif Eddine , Fellah Zine El Abiddine
Published: February 2019

Three series of binary, FeTi (Ti-rich), FeAl and TiAl (Al-rich) alloy samples were produced in an argon arc furnace. An annealing treatment of 72 h at 1000 °C was applied to the samples, giving rise to different equilibrium microstructures depending on chemical composition. Their mechanical properties were studied through the determination of elastic constants that measure the stiffness of the elaborated materials. Young’s modulus of the binary alloys was determined using Resonance Ultrasonic Vibration (RUV). The accuracy of this technique was demonstrated. A scanning electron microscope (SEM) with an energy dispersive spectrometer (EDS) and X-ray diffraction (XRD) made it possible to identify intermetallic compounds FeTi and Fe 2 Ti, FeAl and Fe Al 2 , and TiAl and Ti Al 2 in respective systems Fe–Ti, Fe–Al, and Ti–Al. The link between their composition, microstructure, and elastic properties was established.