bluuebunny/crossref_metadata_2025 huggingface dataset:
IS NEOBLADDER SAFE FOR HIGH GRADE BLADDER CANCER PATIENTS?: EVALUATION OF RADICAL CYSTECTOMY COMPLICATIONS AND ILEAL NEOBLADDER RECONSTRUCTION IN AMC KARIADI GENERAL HOSPITAL
Authors: Stephanie Irene , Soedarso Mohamad Adi
Published: August 2019

Objective: The purpose of this study was to evaluate complications of ileal neobladder reconstruction in high grade bladder cancer patients. Material & Methods: The descriptive study included 12 patients who underwent radical cystectomy and bladder reconstruction with ileal neobladder in Academic Medical Center Kariadi General Hospital Semarang from 2009 until 2016. Base data recorded retrospectively and followed at outpatient clinic. The complications were evaluated from perioperative care, postoperative care, and outpatients clinic. Clavien Dindo classification use to rank complication. Results: The average ages distribution range from 39-70 year. There were 2 patients with comorbid of renal failure, 11 patients with history of TUR and 1 patient underwent adjuvant external radiation. There were 11 patients in high grade bladder cancer (≥T3) and 1 patient with T2. Of the 8 patients underwent orthotopic neobladder procedure and 3 patients underwent cutaneous w-shape procedure. From the histopathology results, 10 patients with high grade transitional cell carcinoma, and 2 patients with invasive urothelial cell carcinoma. There were complication caused by neobladder-related of 1 patient with urinary leakage from ureteroileal anastomose, 1 patient with peritonitis caused by ileo-ileal anastomose leakage, and 1 patients with bowel necrosis caused by internal hernia who need re-operation. All neobladder related complication were 4/33%. From neobladder nonrelated of 1 patient with chronic renal disease and sepsis, and 1 patient with acute renal failure and hyperchlor metabolic acidosis. All of neobladder related complications described above end with mortality (2/16%), except the urinary leakage. Conclusion: Our complication and mortality radical cystectomy - neobladder related rate were 33% and 16% compare with literature show 28-64% and 5.1-8.1%, respectively. Patients selection (<T3, no comorbid) and experience according high volume operation can reduced the mortality rate.
ESWL EFFECTIVENESS FOR LOWER POLE KIDNEY STONES
Authors: Sholihin Riza Mazidu , Soetojo Soetojo , Muris Haviv
Published: August 2019

Objective: To describe the profile of lower pole kidney stone patients who underwent Extracorporeal Shock Wave Lithotripsy (ESWL) and the clearance rate of ESWL for lower pole kidney stones at Soetomo General Hospital from 2012 to 2016. Material & Methods: This research design was analytical retrospective, lower pole kidney stone patients who underwent ESWL in Soetomo General Hospital from 2012 to 2016 who fulfill inclusion criteria become samples in this research. Samples were divided into two group, stone size <15 mm and 15-20 mm. Results: Total samples in this study were 128, consist of 81 males and 47 females. The age average was 48 ± 11.124. The stone size average was 9.5 ± 4.5 mm consisted of 109 patients with stone size <15 mm and 19 patients with stone size 15-20 mm. There were 119 single lower pole kidney stones and 9 multiple ones. From all patients, 77 patients (60.2%) were stones free and the rest (39.8%) were not. Stone free rate for lower pole kidney stones was higher in stone size <15 mm compared with 15-20 mm, 65.2% and 31.5% respectively. Statistical analysis with Chi-square showed significant ESWL clearance rate difference between lower pole kidney stone size <15mm group and 15-20 mm (p<0.05). Conclusion: ESWL was a safe option for lower pole kidney stones with high success rate. There was significant relationship between stone size and stone clearance rate. ESWL was effective for lower pole kidney stones size <15 mm.
THE EFFECT OF SILODOSIN AND SODIUM DICLOFENAC TO REDUCE PAIN AFTER DJ STENT REMOVAL IN SOETOMO HOSPITAL: DOUBLE-BLINDED RANDOMIZED-CONTROLLED TRIAL
Authors: Fathurrahman Hasroni , Soebadi Doddy M , Hakim Lukman
Published: August 2019

Objective: To analyze, measure, compare, prove, and evaluate effectiveness of silodosin, diclofenac sodium, and the combination of both drugs in pain management after stent removal. Materials & Methods: Thirty-three patients were divided into three groups. Group I was given diclofenac Sodium 50 mg, group II was given silodosin 8 mg and group III was given the combination of diclofenac sodium 50 mg and silodosin 8 mg. The Wong Baker Pain Scale (WBPS) was assessed serially: two hours before the DJ stent removal, during DJ stent removal, and after the DJ stent removal (2 hours and 24 hours after). The data was analyzed by ANOVA and Kruskal-Wallis test. Results: In this study, 33 patients who underwent DJ stent removal were obtained. Wong Baker was presented in median (min-max) form. The WBPS study in each group did not differ statistically significant. Lowest WBPS during DJ stent removal was found in group III. Group III was better and statistically significant in reducing pain compared to group I and group II (p<0.05). WBPS two hours after removal in each group decreased and group III was better and statistically significant in reducing pain compared to group II, whereas group III compared to group I had an equivalent effectiveness. While the WBPS 24 hours after removal had the same value and did not differ significantly. No side effects or adverse events were found in the use of diclofenac sodium, silodosin, and their combinations. Conclusion: Single oral dose of diclofenac sodium combined with silodosin is effective to reduce pain after DJ stent removal.
EFFECT OF VITAMIN E (α-TOCOPHEROL) ADMINISTRATION ON SPERM MOTILITY AND MORPHOLOGY OF SPRAGUE DAWLEY STRAIN RATS AFTER CISPLATIN TREATMENT
Authors: Aditya Dimas Visa , Djojodimedjo Tarmono , Soebadi Doddy M
Published: August 2019

Objective: To evaluate the protective effects of vitamin E α-tocopherol isomer against the toxicity of cisplatin on sperm motility and morphology in Sprague Dawley rats. Material & Methods: Twenty-four rats were grouped into four groups (n=6). The control group (CN) was injected with normal saline, second group (CP) was injected with cisplatin, the third group (P1) was injected with cisplatin and vitamin E 50 mg/kgBW for 7 weeks P.O, the fourth group (P2) was injected with cisplatin and vitamin E 200 mg/kgBW for 7 weeks P.O. Vitamin E was given from 3 weeks before cisplatin injection and 4 weeks following cisplatin injection. At 7th week, all the samples were undergoing bilateral orchidectomy. Vitamin E that being used in this study was α-tocopherol isomer. Results: Cisplatin decreased motility and morphology of spermatozoa significantly against controls. Vitamin E 50 mg/kgBW and 200 mg/kgBW significantly increased motility of spermatozoa (p<0.05) compared to those in the cisplatin group only. Vitamin E 50 mg/kgBW, and 200 mg/kgBW did not have a significant difference in spermatozoa motility compare to control groups. Vitamin E 50 mg/kgBW and 200 mg/kgBW could increase the spermatozoa morphology significantly compare to those cisplatin only group. Vitamin E 50 mg/kgBW, and 200 mg/kgBW did not have a significant difference in spermatozoa morphology compared to control groups. Conclusion: α-tocopherol 50 mg/kgBW and 200 mg/kgBW provided a same protective effect against spermatozoa damage especially in motility and morphology aspect due to cisplatin exposure. Therefore, in this study it was more recommended to use α-tocopherol in 50 mg/kgBW dose than 200 mg/kgBW.
THE ROLE OF VITAMIN E (α-TOCOPHEROL) ON TESTOSTERONE LEVEL IN SPRAGUE DAWLEY RATS FOLLOWING CISPLATIN TREATMENT
Authors: Rezia Dian Kartika , Hakim Lukman , Djatisoesanto Wahjoe
Published: August 2019

Objective: To observe the difference of testosterone levels in adult male Sprague Dawley rats treated with combination of cisplatin and vitamin E compared to those treated with cisplatin only. Material & Methods: We used 24 adult male Sprague Dawley rats weight 200–300 grams and randomly assigned into 4 groups (n=6). Rats in negative control group (NC) were given intraperitoneal normal saline injection, while the positive control (PC) group were injected with cisplatin 5 mg/kgBW at the end of the 3rd week. Two other groups, P1 and P2, were injected with cisplatin 5 mg/kgBW and given vitamin E orally 50 mg/kgBW and 200 mg/kgBW, respectively. Cardiac blood was aspirated at the end of the 7th week and processed for analysis of testosterone levels. Results: We recorded a significantly lower testosterone levels in rats treated only with cisplatin 5 mg/kgBW (CP) compared to those in CN group (p=0.006), and those receiving combination of cisplatin and vitamin E 50 mg/kgBW (p=0.003) and 200 mg/kgBW (p=0.001). Though not significant, testosterone levels were higher in P2 group than in P1 group (p=0.702). Conclusion: Exposure to cisplatin can lower testosterone levels in white rats, and the administration of vitamin E gives protection against such effect.
EFFECT OF VITAMIN E (α TOCOPHEROL) ADMINISTRATION ON APOPTOSIS OF GERMINAL CELLS EPITHELIUM TESTIS IN SPRAGUE DAWLEY WHITE STRAIN RATS AFTER EXPOSED BY CISPLATIN
Authors: Nugroho Achmad , Djatisoesanto Wahjoe , Soebadi Doddy M
Published: August 2019

Objective: To determine the differences of germinal epithelial testicular cell apoptosis in white Sprague Dawley strain rat that received combination of cisplatin and vitamin E compared to Sprague Dawley strain rat that received cisplatin only. Material & Methods:  Twenty four Sprague Dawley rats were divided into 4 groups randomly. Group 1 Negative Control (NC) was given an injection of 1 cc 0.9% normal saline intraperitoneally as a placebo, group 2 Positive Control (PC) was given 5 mg/kgBW cisplatin intraperitoneally, group 3 (P1) was given cisplatin injection 5 mg/kgBW intraperitoneally + vitamin E (α tocopherol) 50 mg/kgBW by gavage and group 4 (P2) was given cisplatin injection 5 mg/kgBW intraperitoneally + vitamin E (α tocopherol) 200 mg/kgBW by gavage. Vitamin E (α tocopherol) was given 3 weeks before up to 4 weeks after cisplatin injection. Observation of the germinal epithelial cells apoptosis was carried out by calculating germinal epithelial cells apoptosis in the cross-section preparations of the seminiferous tubule which gave a positive reaction to the apoptag staining, using a 400x magnification light microscope. Results: Apoptosis on positive control (PC) group was different significantly compared to the negative control (NC) group (p<0.05). There was a significant difference in the apoptosis of germinal epithelial testicular cells in the cisplatin + vitamin E 50 mg/kgBW compared to the PC group (p<0.05). The cisplatin + vitamin E 200 mg/kgBW group; had a lower number of apoptosis compared to the cisplatin + vitamin E 50 mg/kgBW (p<0.05). Conclusion: Vitamin E provides a protective effect on decreasing the amount of apoptosis due to cisplatin exposure. The protective effect of vitamin E is dose-dependent.
COMPARISON OF EFFICACY AND SAFETY SILODOSIN 8 MG ONCE DAILY AND SILODOSIN 4 MG TWICE DAILY IN BPH PATIENTS WITH LUTS
Authors: Diansyah Ramzie Nendra , Renaldo Johan , Djatisoesanto Wahjoe , Hakim Lukman
Published: August 2019

Objective: This study was aimed to compare the efficacy and side effect of silodosin 8mg once daily and silodosin 4mg twice daily in BPH-LUTS patients after 4 and 12 weeks. Material & Methods: Single blind randomized controlled trials in 60 male patients aged ≥45 years with BPH-LUTS from July 2017 to October 2017 was divided into groups who received 8mg of silodosin once daily and those who received 4mg of silodosin twice daily. Efficacy and adverse events were evaluated after 4 and 12 weeks of treatment. Results:  There was no significant difference of mean age of the two groups was 67.93 ± 6.49 years and 69.07 ± 6.28 years respectively (p 0.49). Both doses of this drug decreased the International Prostate Symptom Score (IPSS) and significantly increased the maximum urinary flow (Qmax) (p<0.05) but there was no significant differences between the two groups (p>0.05). Ejaculation disorder was the most common side effect in all groups (6.7% and 5%) and there was no significant difference between the two groups (p>0.05). Conclusion: The administration of 8mg of once daily silodosin has similar efficacy as 4mg twice daily silodosin. There were no adverse events differences in the two groups. Ejaculation disorder is the most common adverse event of silodosin administration.
ANALYSIS OF DIFFERENCES DEGREE OF SEVERITY AND QUALITY OF LIFE OF BPH DIABETES WITH BPH NON-DIABETES PATIENTS
Authors: Kurnia Putra Prayoga Triyadi , Wahyudi Septa Surya , Novi M Ancah Caesarina
Published: August 2019

Objective: Benign Prostatic Hyperplasia (BPH) is a benign tumor located in prostate caused by prostate cell that will continuously grows which covalent with the aging process and the dihidrotestosteron level (DHT) increase. Prostate Hyperplasia can stop the urethra pars prostatics and causesa clogging in the urine’s flow excretes from bladder. Lower Urinary Tract Symptomps (LUTS) is a bladder muscle compensation mechanism to excrete urine. Diabetes Mellitus (DM) is one of the risk factors of BPH. This research aimed to find the differences on the degree of severity and quality of life BPH DM with BPH non-DM. Material & Methods: This research was observational analytic with cross sectional design which done to 32 subjects that consist of 16 BPH-DM subjects and 16 BPH non-DM in Bina Sehat Hospital Jember, Paru Hospital Jember, and Bhayangkara Hospital Bondowoso which meet to the inclusion and exclusion criteria. Data acquired from lead interview result using International Prostate Symptoms Score (IPSS) questionnaire to evaluate the degree of severity and World Health Organization Quality of Life (WHOQOL-BREF) questionnaire to evaluate the quality of life. The data processing using Mann Whitney’s comparative test. Results: IPSS and physic domain, psychology and social had p value in a row 0.001; 0.000; 0.001; and 0.001. Conclusion: It showed that there was a meaningful difference between BPH DM with BPH non-DM. Environment domain had p value of 0.373. It showed the non-meaningful difference between BPH DM with BPH non-DM.
BLADDER RECONSTRUCTION DURING SEPARATION OF A CONJOINT TWIN ISCHIOPAGUS TRIPUS
Authors: Effendi Fajar , Siregar Safendra , Sibarani Jupiter
Published: August 2019

Objective: Conjoined twins represent one of the rarest congenital anomalies occurring with a varying incidence of about approximately 1 : 50.000 - 1 : 200.000 births. Ischiopagus conjoined  twinning (Fuse at the hip region) is even rare representing only 6% of all conjoined  twins. Here we report our experience in lower urinary tract reconstruction during separation of a conjoined twin ischiopagus tripus in Hasan Sadikin Hospital, Bandung. Case(s) Presentation: Two years old female conjoined twins, weighing in total of 8 kilograms, were brought to our hospital. The twins were fused  at  the lower  halves of  their bodies with two separate lower limbs at the right side and a fused left lower limb. External genitalia were absent. From CT Angiography we found four kidneys, two in each child with two separate bladders, with right ureter of baby A and left ureter of  baby B enter the  right bladder, while left ureter of  baby A and  right ureter of  baby B enter the left bladder. There was one cloaca that drains urine and feces. During the separation surgery, we performed ureteroneocystostomy and temporary ureteral stenting, followed by cystostomy. The pediatric surgeon performed bowel separation by stapling technique, pelvic wall separation, ileostomy, and pelvic floor reconstruction. The orthopedic surgeon performed femur separation, pelvic floor reconstruction, reconstruction of the pelvic ring, and femur reconstruction. The patients underwent defect closure, which performed by plastic surgeon. The operation was successful, without any complication to the kidney and the urinary tract of both babies. Discussion: Ischiopagus conjoined twins are the most complex conjoined twins and occur in only 6% of all conjoined twin cases. Ischiopagus is usually located along the axis with the head located on the opposite side. This case usually has one umbilicus and the two bodies are fused below this level, the union occurs in the lower abdomen and the pelvis. The internal organs that usually coalesce in cases of ischiopagus conjoined twins are liver, lower gastrointestinal, and genitourinary. The fused gastrointestinal part is the ileo-colic part of terminal ileum (Meckel's diverticulum). Conclusion: The separation of conjoined twin is a unique challenge due to its complex anatomy and physiology. Although advancement in imaging and monitoring has improved the survival rate separation can be successfully achieved only with meticulous planning and team work.
FIRST EXPERIENCE IN VIDEOURODYNAMIC STUDY AT CIPTO MANGUNKUSUMO HOSPITAL IN 2012-2014
Authors: Tambunan Nicholas Albert , Rahardjo Harrina E
Published: August 2019

Objective: Accuracy of diagnosis is a fundamental thing in terms of plan of treatment. Nowadays, symptoms from lower urinary tract can be diagnosed accurately with videourodynamic study (VUDS). Videourodynamic combines a fluoroscopic voiding cystourethrogram with multichannel urodynamics, allowing anatomic and functional assessment of the bladder and outlet. Material & Methods: This research is a descriptive retrospective. Data was taken from the patients who underwent VUDS at Department of Urology Cipto Mangunkusumo Hospital from 2012 to 2014. Patient’s  characteristics were gender, age, chief complaint, working diagnosis pre investigation, and diagnosis after VUDS was performed. Then, data was analyzed in a descriptive fashion and presented using tables and narative form. Results: There were 8 male patients (67%) and 4 female (33%) who underwent VUDS. Most of the patients were children (75%). Five patients (42%) complained about incontinence with or without other LUTS, only 1 patient (8%) had LUTS and disuria. Overall, working diagnosis pre investigation was neurogenic bladder with various causes. We found a variable diagnoses after VUDS. At filling phase, we found 7 patients (58%) with small bladder capacity, 5 patients (42%) with low bladder compliance then followed respectively by overflow incontinence (33%), detrusor overactivity (17%) and urethral sphincter incompetence (8%). At voiding phase, the most common abnormality detected were detrusor underactivity (42%), followed by infravesical obstruction (8%). VUR was found both at filling phase (42%) and voiding phase (33%). Conclusion: VUDS could be the first choice of modality for diagnosing dysfunction of lower and upper urinary tract especially in neurogenic cases.
RISK FACTORS OF MORTALITY IN CHILDREN WITH WILMS’ TUMOR AT SOETOMO HOSPITAL SURABAYA
Authors: Shanty Maria Christina , Yuniarchan Sherly , Andarsini Mia Ratwita , Ugrasena I Dewa Gede , Permono Bambang , Prasetyo Risky Vitria
Published: August 2019

Objective: Wilms’ tumor is the most common childhood renal tumor for about 6% of pediatric malignant disease. The 5-year survival rate in United States increased from approximately from 70% (1970-1973) to 92% (1989-1996). This study was aim to analyze the risk factors of mortality in children with Wilms’ tumor. Material & Methods: A cross-sectional study was conducted in children with Wilms’ tumor at Soetomo Hospital during 2006-2011. The data of demographic, clinical profile, complete blood count, blood urea nitrogen, glomerular filtration rate, histological type, disease stage, metastases and relapse were analyzed as risk factors of mortality using logistic regression. Results: There were 37 Wilms’ tumor children and 5 children were excluded because of incomplete data. The mean age was 3.0 (SD 2.6) years, and male-to-female ratio was 2.5 : 1. There were 5/32 children in stage I, 7/32 children in stage II, 8/32 children in stage III, 11/32 children in stage IV, and 1/32 children in stage V. There were 15/32 children underwent operation. Complete remission occurred in 12/32 children and 1/32 children relapsed. There were 20/32 children died, associated with anemia (P=0.033, OR=6.111, 95% CI=1.056-35.352) and advanced stage (P=0.021, OR=8.000, 95% CI=1.575-40.632). The risk of mortality increased 3.284 folds with every increased stage (P=0.007, 95% CI=1.338-7.775). Conclusion: Disease stage is the significant risk factor of mortality in children with Wilms’ tumor.
THE EFFECT OF ERYTHROPOIETIN SUPPLEMENTATION ON SPERM MOTILITY AND MORPHOLOGY IN WISTAR RAT AFTER LIGATION RELEASE OF THE VAS DEFERENS
Authors: Pramanta Aditya , Renaldo Johan , Soebadi Doddy M
Published: August 2019

Objective: The patency rates after vasectomy reversal ranges from 71-97%, but there is 26-72% possibility of persistent infertility. Dysfunction or obstruction of the epididymis and oxidative stress are thought to be the important cause of male infertility by disrupting spermatozoa maturation process, causing poor sperm quality. Human erythropoietin or better known as EPO is a glycoprotein hormone that has been purified since three decades ago. Research on the EPO has evolved and become a major research topic the researchers aimed as a therapeutic agent. The cloning and expression of erythropoietin has developed recombinant erythropoietin as a drug that serves as an anti-oxidant, anti-apoptotic and anti-inflammatory. This study aimed to determine the effect of erythropoietin supplementation on sperm motility and morphology in Wistar rat after the release of the vas deferens’ ligation. Material & Methods: Twenty four male Wistar rats were randomly divided into four groups (6 each). On the vasectomy group, the vas deferens were serially ligated for 7 weeks using a non-absorbable suture. The vasectomy reversal group get the same surgical treatment and after 7 weeks the ligation were released. While as in the erythropoietin group, recombinant eryhtropoietin (1000 IU/kg) was administered intraperitoneally three times for 1 week after releasing the ligation. Normal control animals received no surgical manipulation and followed by sperm retrieval for analysis. Eosin-stained slides were prepared to assess the motility and morphology of sperm cells and observed under a light microscope. Results: Ligation of vas deferens significantly decreased sperm motility and morphology. Releasing the ligation of the vas deferens did not improve the sperm motility and morphology. Supplementing eryhtropoietin 1000 IU/kg 3 times for a week after releasing the ligation did not improve the sperm motility and morphology. Conclusion: Erythropoietin supplementation did not improve the sperm motility and morphology in Wistar rat after releasing the ligation of vas deferens.
THE EFFECTIVENESS OF TAMSULOSIN, SOLIFENACIN, AND COMBINATIONS THERAPY TAMSULOSIN ADDED SOLIFENACIN ON LOWER URINARY TRACT SYMPTOMS AFTER DOUBLE J STENT INSERTION
Authors: Pramana Ida Bagus Putra , Rizaldi Fikri , Djojodimedjo Tarmono
Published: August 2019

Objective: Insertion of DJ Stent is a procedure that is often done by urologist. Insertion of DJ Stent can cause LUTS complaints and greatly affect the physical and psychosocial health of patients. The aim of this study was to determine the effectiveness difference of tamsulosin therapy 0.4 mg/day, solifenacin 5 mg/day and the combination of tamsulosin therapy 0.4 mg/day added solifenacin 5 mg/day to manage LUTS complaint after DJ Stent insertion. Material & Methods: This study was a randomized placebo-controlled trial. There were 4 groups, group I received placebo, group II received tamsulosin 0.4 mg/day, group III received solifenacin 5 mg/day, and group IV received combination therapy of tamsulosin 0.4 mg/day added solifenacin 5 mg/day. Evaluation based on International Prostatic Symptom Score (IPSS) and Ureteral Stent Symptom Questioner (USSQ) score. Data were analyzed using SPSS 21.0. It is said to be significant if p<0.05. Results: There were a total of 32 samples consist of 19 (59.3%) men and 13 (40.6%) women. There were significant improvements in the score of total IPSS, IPSS storage and IPSS quality of life score in patients who received combination therapy (p<0.05) when compared with patients who received monotherapy. The highest decrease in USSQ scores 1, 2, 3, 4, 5 and 6 were in the group that received combination therapy when compared with the monotherapy group. Conclusion: The combination therapy is safe and effective to improve IPSS total, IPSS storage and IPSS Quality of Life scores compared with monotherapy.
COMPARISON BETWEEN TRANSRECTAL ULTRASONOGRAPHY GUIDED TRANSRECTAL PROSTATE BIOPSY AND TRANSRECTAL ULTRASONOGRAPHY GUIDED TRANSPERINEAL PROSTATE BIOPSY
Authors: Halfian Randa , Soebadi Doddy M , Rizaldi Fikri
Published: August 2019

Objective: Prostate cancer is the fourth most common malignancy in men. TRUS guided transperineal prostate biopsy and TRUS guided transrectal prostate biopsy are two main approach to take prostate tissue as diagnostic of prostate cancer. To compare prostate biopsy approach between TRUS guided transrectal and TRUS guided transperineal toward duration of examination, pain perception, and complications. Material & Method: This study was an experimental study with prospective approach. There were two groups, group one was performed TRUS guided transrectal prostate biopsy (TRB) and group two was performed TRUS guided transperineal prostate biopsy (TPB). Evaluation was based on the duration of examination, pain perception, and complication. Data was analyzed using independent T test for duration of examination and Mann-Whitney test for pain perception. Data was performed using SPSS 21.0 version. The statistical significant difference was consider if p value <0.05. Results: There were 20 samples in this study. There was a significant difference in the duration of examination, the average duration of TPB examination (17.40 ± 2.50) was longer than the duration of TRB examination (14.1 ± 2.77). There was no significant statistical difference between TPB group and TRB group in pain perception when USG probe into the anal (p=0.65), anesthesia process (p=0.28), prostate tissue sampling (p=1.00), and post biopsy (p=0.34). Rectal bleeding was found mostly in TRB group (40%) compared to TPB group (0%). Hematuria was experienced by three patients (30%) in TRB group and two patients (20%) in TPB group. Conclusion: TRB was more effective in duration of biopsy than TPB. The complications of rectal bleeding and hematuria were more in TRB group than TPB. The pain perception were the same between both groups. There were no fever, sepsis, hematospermia and vasovagal event in two groups.
THE EFFECT OF NIFEDIPINE ON SURVIVE CELL, APOPTOTIC CELL AND NECROTIC CELL OF IPSILATERAL TESTICULAR GERMINAL EPITELIAL CELLS ON MALE WISTAR RATS WITH UNILATERAL TESTICULAR TORSION
Authors: Kurniawan Andrie Rhomdhon , Hakim Lukman , Soebadi Doddy M
Published: August 2019

Objective: This study aimed to compare the number of survival, apoptotic and necrotic cells of ipsilateral testicular germinal epithelial cells in male wistar rats with unilateral testicular torsion between nifedipine given and control groups. Material & Methods: Thirty male wistar rats aged 10-12 weeks were randomly divided into 5 groups, each consisted of 6 rats. The negative control group (KN) underwent a sham procedure and left orchidectomy. Positive control group 4 (KP4) and 10 (KP10) performed left torsio testis 3 x 360 degrees medially for 4 hours and 10 hours respectively, then performed orchidectomy 4 hours after detorsion. The 4-hour (N4) and 10 hours (N10) nifedipine treatment group received the same treatment with positive control, but 30 min before detorsion performed, nifedipine were given intraperitoneal 100μg/kg. Within 1 hour after orchidectomy, cell count was calculated using flow cytometry. Results: It was found that the 4 (N4) and 10 hours (N10) nifedipine treatment group had a higher survival cells and also a lower number of apoptotic and necrotic cells compared to the positive control group. It was found that the 10 hours nifedipine treatment group (N10) had a lower number of apoptotic and necrotic cells compared to the 10 hour positive control group (KP10). The difference was statistically significant with p value <0.05. However, in KP4 and N4 group compared with KP10 and N10 group, higher apoptotic cells was obtained. This was a new phenomenon that needs to be investigated more deeply. Conclusion: Intraperitoneal administration of nifedipine prior to testicular detorsion may reduce the number of apoptotic and necrotic cells of testicular germinal epithelial cell, and may increase the number of survival cells in ipsilateral testes with unilateral testicular torsion.
THE EFFECTIVITY OF EUTECTIC MIXTURE OF LOCAL ANESTHETICS CREAM AS EXTRACORPOREAL SHOCKWAVE LITHOTRIPSY ADJUVANT ANALGESIA IN SOETOMO GENERAL HOSPITAL
Authors: Sholihin Riza Mazidu , Hakim Lukman , M. Soebadi Doddy
Published: August 2019

Objective: The Extracorporeal Shockwave Lithotripsy (ESWL) procedure is the first choice for kidney stone therapy with the size ≤20mm. One of the complications of ESWL is the pain. Pain control during ESWL is essential to maintain the focus point of ESWL and give enough time to achieve complete stone fragmentation. Until now there is still no data about the effectiveness of Eutectic Mixture of Local Anesthetics (EMLA) cream as an adjuvant analgesic for ESWL procedure in Soetomo Hospital Surabaya. To compare the onset of pain and ESWL Wong-Baker Pain Scale (WBPS) between the EMLA group and placebo group. Material & Methods: The design of this study was a single-blind randomized control trial comparing the onset of pain and Wong Baker pain scale between the patient in EMLA group and placebo one. WBPS is assessed in minute 15, 30, 45, and 60 of ESWL sessions and 60 minutes post ESWL procedure. The results were analyzed with SPSS. Pain onset and differences of WBPS were tested by using independent T-test if the data is normally distributed and using Mann-Whitney test if the data is not normally distributed. Results: 10 patients were obtained in each group. The mean onset of pain in the EMLA group was longer than the mean onset of pain in the placebo group but statistically not significant (p>0.05). The WBPS in the EMLA group was significantly lower compared with the placebo group in the 30, 45, and 60 minutes of ESWL (p<0.05). Conclusion: EMLA cream application before ESWL was effective and safe as an adjuvant analgesic to reduce pain during ESWL.
THE EFFECTS OF NICOTINE EXPOSURE PER INHALATION TO THE CHANGE OF MOTILITY AND MORPHOLOGY OF THE RAT’S SPERM
Authors: Nugroho Puruhito Eko , Rizaldi Fikri , Soesanto Wahjoe Djati
Published: August 2019

Objective: Smoking are known to have detrimental effect on sperm. The effects are suspiciously come from nicotine as its main pharmacologic component. This study is carried out to analyze the effect of nicotine exposure per inhalation to the difference of motile sperm percentage and normal morphology sperm percentage of male wistar rats. Material & Methods: Thirty male rats were used for this research. They were randomly divided into 5 groups and treated with nicotine inhalation 0.5 mg/kgBW,  1 mg/kgBW, 2 mg/kgBW and 4 mg/kgBW for 30 days while the control rats were not given any treatment. At the end of experiment, sperm analysis was carried out to measure the percentage of motile sperm and percentage of sperm with normal morphology. Results: Percentage of motile sperm significantly decreased (p<0.05) in all treatment groups compared to control group. Comparison between treatment groups revealed that the percentage of motile sperm significantly decreased in 0.5 mg/kgBW vs 2 mg/kgBW, 0.5 mg/kgBW vs 4 mg/kgBW, and 1 mg/kgBW vs 4 mg/kgBW. Percentage of normal morphology sperm decreased significantly (p<0.05) in 1 mg/kgBW, 2 mg/kgBW, and 4 mg/kgBW compared to control groups. Comparison between treatment groups revealed that there were no significant decreased between each treatment groups. Conclusion: This research conclude that nicotine exposure per inhalation can deteriorate the percentage of motile sperm and the percentage of normal morphology sperm of male wistar rats.
PENGEMBANGAN MEDIA PEMBELAJARAN ILMU PENGETAHUAN ALAM BERBASIS SWISHMAX DI MIN 2 PALEMBANG
Authors: Riska Dispi , Afandi Muhamad , Astuti Mardiah
Published: August 2019

The purpose of this study was to determine the level of validity, practicality and effectiveness of the development of Swishmax-based Natural Sciences learning media in IVG MIN 2 Palembang. This research method uses Research and Development (R & D) methods. The research and development model used is the tressmer model with the stages of research: the preliminary stage (preparation and design), the formative evalution stage (self evaluation, expert review, one to one, small group, and field test). Data collection techniques using questionnaires and tests. Data analysis techniques use percentages. The results of this study include: (1) Development of Swishmax-based Natural Sciences learning media in Palembang IVG MIN 2 Class can be categorized as valid. This is indicated by the acquisition of media expert validation scores of 84.5, language experts 82, and material experts 90; (2) The practicality level of the application of the development of Swishmax-based Natural Sciences learning media in Palembang IVG MIN 2 Class is very practical. This can be seen from the acquisition of the average questionnaire score of 100 in the field test stage; (3) The effectiveness of the development of Swishmax-based Natural Sciences learning media in Palembang IVG MIN 2 Class is very effective. It is known that the level of mastery learning in classical students reaches 95% in the field test stage.
PENDIDIKAN ANAK USIA DINI PERSFEKTIF ISLAM DAN BARAT (Studi Pustaka Tentang Teori PAUD)
Authors: Rosita Rosita , Buchori muslim Ahmad
Published: August 2019

This library research was conducted with a background of enriching discourse and paradigm regarding the pattern of Early Childhood Education (PAUD) in Islamic and Western perspectives. In addition, researchers want to detect and see the pioneer of PAUD theory. Because there are some similarities from the originators of western theory with the Islamic PAUD theory. Although there are different things between the two perspectives. One of them, the western perspective reveals the beginning of the right AUD education since the womb, but vice versa with AUD education in the Islamic perspective, that is, starting from choosing a partner. So that the idea of this research arises by using a literature analysis. Thus, this research is expected to provide a new positive discourse and have a purpose to provide an actual understanding of what is happening around us.
PENGEMBANGAN BUKU AJAR MATA KULIAH PENDIDIKAN IPS UNTUK PGMI MENGGUNAKAN EXPANDING COMMUNITY APPROACH
Authors: Irfan Islamy M.
Published: August 2019

This research is a continuation of the research on the Development of Textbooks for Social Studies Courses with the 2013 Curriculum Based Concept Approach. Development with Expanding Community Approach is used to create a hierarchical material that starts from a simple concept to a broader concept while paying attention to the distribution of Social Studies material at the level of Elementary School based on the 2013 Curriculum. Research & development of textbooks for social studies education MI / SD with Expanding Community Approach aims to develop social studies textbooks in the Elementary School Teacher Education department that can be used as learning resources for students in Social Studies courses. This development research uses the Thiarajagan 4-D model with the steps of Define, Design, Develop, and restrictions on Desseminate. Research on the development of Social Studies course textbooks for Elementary School Teacher Education with Expanding Community Approach received a very decent category with a score of 81% from material experts, a decent category with a score of 80% from linguists, and a very decent category with a score of 87% from design experts. The data can provide the conclusion that the textbooks of Social Studies courses using the expanding community approach are categorized as feasible.
FUN ARABIC TEACHING WITH SONG MEDIA FOR PRIMARY SCHOOLS/PENGAJARAN BAHASA ARAB MENYENANGKAN DENGAN MEDIA LAGU UNTUK MADRASAH IBTIDAIYAH
Authors: Mufidah Nuril
Published: August 2019

Primary students, especially the basic class, have many difficulties learning Arabic because they are not used in daily communication, and there are differences in Arabic alphabets. There needs to be learning alternatives that are appropriate for the child's age and bring Arabic closer. Arabic is a close foreign language for students of Muslim faith; because they used to recite daily Arabic prayers. So that Arabic can be said to be far written in Indonesian but close verbally in the everyday religious life of students.This study describes vocabulary learning by singing in the process of learning Arabic for children. The research subjects of class 1 MIN 1 Malang city in the academic year 2018/2019, using a type of qualitative research with the method of collecting observation and interview data. The results of this study indicate that singing in vocabulary / mufrodat teaching can increase students' motivation and learning attractiveness towards Arabic so that students can be happy to add new Mufrodat next to be helped to write because they feel close to the word taught by singing. Arabic is close verbally but far in reading and writing for children can be overcome by using songs and songs as an alternative to teaching Arabic for children.
STUDI PEMANFAATAN MINYAK JELANTAH SEBAGAI BAHAN BAKU PEMBUATAN BIODIESEL
Authors: Prasetyo Joni
Published: August 2019

ABSTRAK Pemanfaatan minyak jelantah sebagai bahan baku pembuatan biodiesel memberikan beberapa manfaat seperti mengurangi pencemaran lingkungan di began air. Karena masyarakat sekarang ini cenderung membuang minyak jelantah dengan kualitas yang sangat rendah. Selain itu, bahan baku minyak jelantah ini sudah bukan lagi dikategorikan sebagai bahan pangan mengingat bentuknya yang hitam dan encer. Pembuatan biodiesel dengan transesterifikasi suasana basa ini bisa dilakukan dengan biaya yang murah dengan mengggunakan NaOH teknis yang banyak dijual dipasar dan ethanol teknis. Optimasi dilakukan dengan mempertimbangkan parameter jumlah NaOH teknis 2N mulai dari 10, 25, 40, 55 dan 70 ml dan exces ethanol 0, 25, 50, 75 dan 100%. Proses transesterifikasi dilakukan pada suhu 80°C selama tiga jam dalam pengadukan yang homogen. Kondisi optimum didapatkan dengan menggunakan 10 ml NaOH 2M dan 0% exces ethanol sebesar 196.64 gr/200 gr minyak jelantah. Kondisi ini juga mampu meminimalkan volume glycerol yang hanya berjumlah 79.79 ml. Secara keseluruhan FFA biodiesel ini sudah dibawah 0.5% sesuai dengan yang diharapkan. Adapun kualitas biodiesel melalui pengamatan masa jenis yang menunjukan 0.937 gr/ml masih harus dilakukan perlakukan lebih lanjut dari target yang diharapkan 0.900 gr/ml, yaitu dengan melakukan penguapan air dalam oven pada suhu lebih tinggi dan durasi yang lebih panjang. Kata kunci: biodiesel, minyak jelantah, transesterifikasi, Fatty Acid Ethyl Ester (FAEE)
Gamma Distribution of FAST Feature for Statistical Image Modelling in Fingerprint Image Classification
Authors: Yu Win Hnin Yu , Htwe Pyone Htwe
Published: August 2019

A unique method for modelling Features from accelerated segment test (FAST) with the Gamma distribution for statistical image data is introduced. Instead of using an image's FAST feature instantly; we design the FAST function to decrease the other global extraction function. The method of moment is used to predict Gamma distribution parameters. FAST's mathematical depiction is the depiction of matrix and is too complicated to be implemented in the ranking of images. We are therefore proposing a fresh statistical function to display the picture in a few dimensional numbers. Our proposed feature utilizes FAST method of Gamma distribution that can be used directly in the identification of fingerprint images. We demonstrate that the Gamma distribution works with FAST and has been effectively implemented in the identification of fingerprint images. To show the benefits of the proposed feature, Shivang Patel Fingerprint Database is used on which classifier evaluation and state-of - the-art comparison are performed.
Isolation and Identification of Pesticides Degrading Bacteria from Farmland Soil
Authors: Rahman Md Atikur , Arefin ASM Shamsul , Saha Otun , Rahaman Md Mizanur
Published: August 2019

Pesticides are recognized to be the threat to the environment and associated with a wide range of serious diseases including respiratory diseases, cancer and even birth defects. In this study, six-different bacterial strains capable of degrading Carbofuran, Emamectin Benzoate and Thiamethoxam were isolated from eight different soil samples. The isolates were characterized by using different conventional and molecular methods. The strains were identified molecularly into different genotypes using amplified ribosomal DNA restriction analysis (ARDRA) and partial sequencing of 16S rDNA. The ARDRA pattern clustered them into 3 groups. Among the isolates three were identified as Achromobacter spp. and one as Diaphorobacter sp. by biochemical tests. It was further confirmed by the partial 16S rDNA sequencing. The two identified potential bacteria can be used for biodegradation of different pesticides which can have a significant environmental impact in soil farm.

Bangladesh J Microbiol, Volume 35 Number 2 December 2018, pp 90-94
Seasonal variation of bacterial load in river and lake waters of Dhaka city, Bangladesh
Authors: Sikdar Md Suprio Sadat , Abony Maruf , Zerin Tamanna , Banik Avijit , Datta Suvamoy
Published: August 2019

Surface water is often contaminated due to human excreta and urban and industrial pollution. The increased population growth and industrialization are likely to exacerbate the situation. Microbiological analysis of waters from rivers (Turag and Buriganga) and lakes (Banani and Dhanmondi) around Dhaka city were conducted for Spring, Monsoon and Fall seasons of the year, 2016 and 2017. Total Viable Count (TVC), Total Coliform Count (TCC), Total Fecal Coliform Count (TFCC) and Total Salmonella Shigella Count (TSSC) were conducted to obtain bacterial load in both enriched and without enrichment water samples. All the Isolates were identified by microscopy, cultural characteristics and biochemical methods. Most of the water reservoirs have a decline in the bacterial load in monsoon where the microbial load of pathogens is highest during spring. Without enrichment, E. coli, Enterobacter sp., Klebsiella sp. and S. aureus were abundant, where others like Shigella sp., Proteus sp., Serratia sp., Pseudomonas sp., Acinetobacter sp., and Alcaligenes faecalis mostly exhibited growth following enrichment. Results indicate that pathogenic environmental isolates can cause serious health issue if water is left untreated or poorly treated from reservoirs within and around Dhaka city.

Bangladesh J Microbiol, Volume 35 Number 2 December 2018, pp 116-121
The Microbiological Quality of Commercial Fruit Juices-Current perspectives
Authors: Ahmed Tasnia , Das Kamal Kanta , Uddin Md Aftab
Published: August 2019

The purpose of this review article is to introduce the importance of fruit juices for human health living in the country and in a broad, and to develop awareness among the people about the diseases caused by pathogens associated with fruit juice. Health benefits of juices have been included in this article and how the same juice can cause problems among people of different ages have been discussed. Contamination sources and the ways to prevent them is very important issue in protecting public health Some future recommendations for fruit juices have also been added in this article. Different diseases caused by various microbial agents and the associated symptoms after consuming contaminated fruit juices worldwide are discussed in this review. This review was aimed at the possible sources of microbial contamination, disease caused by them and determining some ways to avoid such phenomena. From the information provided here, it was noticeable that commercial fruit juice can also harbor pathogenic microorganisms which can cause serious disease outbreaks. The contamination can also be initiated during in house consumption if lack of awareness prevails among the consumers. Manufacturing process should be much more strict in this regard to assure the public health safety. Commercially available fruit juices are consumed worldwide among different ages of people and if not processed properly, this healthy drink may be hazardous for human health.

Bangladesh J Microbiol, Volume 35 Number 2 December 2018, pp 128-133
Adaptation of environment friendly technology by reducing pesticide use for cucumber cultivation at Farmers’ level
Authors: Alam MAU , Hossain M , Mia MI , Talukder MAAH , Haque MMU , Khandakar J
Published: August 2019

A field experiment was conducted in the farmer’s field at Salaipur, Mithapukur, On Farm Research Division, Rangpur during 2015-2016to control cucurbit fruit fly effectively through the use of sex pheromone trap. The trial was conducted among six farmers. Three treatments viz., T1 (Sex pheromone + Poison bait + Sanitation (9 spot)), T2 (Sex pheromone + Poison bait + Sanitation (16 spot)) and T3 (Farmers practice) were compared.  The total land area was 7200m2. The higher fruit yield (63.99t/ha) was obtained from T2 (Sex pheromone + Poison bait + Sanitation (16 spot). The lower fruit yield (27.99 t/ha) was obtained from T3. The gross margin (Tk. 294706/ha) and gross return was also higher with the use of T2 (Sex pheromone + Poison bait + Sanitation (16 spot).The highest gross margin and gross return was found in T2 (Sex pheromone + Poison bait + Sanitation (16 spot) treatment. Use of insect lures can improve safe vegetable production as well as yield. Innovative agricultural technologies have the potential to increase yield and income of smallholder vegetable farmers in the northern region of Bangladesh.

Progressive Agriculture 30 (2): 150-156, 2019
Control fruit fly for profitable sweet gourd production
Authors: Hossain M , Mia MI , Talukder MAAH , Laily UK , Haque MMU , Khandakar J
Published: August 2019

A field experiment was conducted in the farmer’s field at Salaipur, Mithapukur, OFRD, Rangpur during 2015-2016 to control cucurbit fruit fly effectively through the use of sex pheromone trap. The trial was conducted among six farmers. Three treatments viz., T1 (Sex pheromone+Poison bait+Sanitation (9 spot)), T2 (Sex pheromone+Poison bait+Sanitation (16 spot)) and T3 (Farmers practice) were compared. The total land area was 7200m2. The higher fruit yield (25.86 t/ha) was obtained from T2 (Sex pheromone+Poison bait+Sanitation (16 spot). The lower fruit yield (21.43 t/ha) was obtained from T3. The gross margin (Tk.96375/ha) and BCR (3.92) was also higher with the use of T2 (Sex pheromone+Poison bait+Sanitation (16 spot). The findings related to control of fruit fly of sweet gourd will be an important role in pest management safely and it will be play important for farmer’s profitability.

Progressive Agriculture 30 (2): 173-178, 2019