bluuebunny/crossref_metadata_2025 huggingface dataset:
An Ultra-Compact and Low-Cost LAMP-Based Virus Detection Device
Authors: Guo Dong , Ling Zhengrong , Tang Yifeng , Li Gen , Zhang Tieshan , Zhao Haoxiang , Ren Hao , Shen Yajing , Yang Xiong
Published: July 2024

Timely and accurate detection of viruses is crucial for infection diagnosis and treatment. However, it remains a challenge to develop a portable device that meets the requirement of being portable, powerless, user-friendly, reusable, and low-cost. This work reports a compact ∅30 × 48 mm portable powerless isothermal amplification detection device (material cost ∼$1 USD) relying on LAMP (Loop-Mediated Isothermal Amplification). We have proposed chromatographic-strip-based microporous permeation technology which can precisely control the water flow rate to regulate the exothermic reaction. This powerless heating combined with phase-change materials can maintain a constant temperature between 50 and 70 °C for a duration of up to 49.8 min. Compared with the conventional methods, it avoids the use of an additional insulation layer for heat preservation, greatly reducing the size and cost. We have also deployed a color card and a corresponding algorithm to facilitate color recognition, data analysis, and storage using a mobile phone. The experimental results demonstrate that our device exhibits the same limit of detection (LOD) as the ProFlex PCR for SARS-CoV-2 pseudovirus samples, with that for both being 103 copies/μL, verifying its effectiveness and reliability. This work offers a timely, low-cost, and easy way for respiratory infectious disease detection, which could provide support in curbing virus transmission and protecting the health of humans and animals, especially in remote mountainous areas without access to electricity or trained professionals.
Islamic Principles and UAE Policies Regarding Protecting Senior Citizens’ Rights and Safety
Authors: Albrithen Abdulaziz , Almemari Mariyam , Briskman Linda
Published: July 2024

Islam influences Muslim societies through rules, regulations, and legislation. This paper highlights Islamic principles and legislation that protect the rights and dignity of older adults and compares them to policies and laws that have been applied and implemented in the United Arab Emirates. A comparative method was utilised to conduct this study, relying on sources that present the rights of older adults in Islamic Sharia, as well as official sources from the United Arab Emirates, where information on laws and regulations related to older adults is published.
PERAN SERTIFIKASI HALAL TERHADAP MINAT BELI KEMBALI DENGAN MEDIASI KEPERCAYAAN
Authors: Apriliyanto Nanang , Prabasari Bonita
Published: July 2024

Penelitian ini mempunyai tujuan mengidentifikasi hubungan sertifikasi halal terhadap minat beli kembali dengan mediasi kepercayaan pada konsumen di restoran luar negeri. Penelitian ini diharapkan menjadi referensi bagi restoran dan usaha kuliner makanan tingkat menengah untuk dapat diterapkan agar konsumen memiliki minat datang kembali ketempat usaha mereka. Penelitian ini berbentuk kuantitatif dengan jenis penelitian eksplanatori. Jumlah sampel pada penelitian ini adalah 200 responden dengan sumber data primer yang disebarkan melalui googleform secara online. Teknik analisis data yang digunakan adalah SEM dengan perangkat lunak SmartPLS. Penelitian ini mendapatkan hasil bahwa sertifikasi halal mampu menujukkan kontribusi secara positif dan signifikan terhadap kepercayaaan dan minat beli kembali. Sedangkan kepercayaan sendiri mampu menunjukkan kontribusinya secara positif dan signifikan terhadap minat beli kembali. Serta, kepercayaan mampu menjadi variabel mediasi pengaruh sertifikasi halal terhadap minat beli kembali.
Kata kunci: Minat Beli Kembali, Kepercayaan, Sertifikasi Halal
PENGARUH SUKU BUNGA THE FED TERHADAP NET INTEREST MARGIN DENGAN MODERASI KESENJANGAN DANA (GAP) DAN DAMPAKNYA TERHADAP PROFITABILITAS
Authors: Sunaryo Sunaryo , Nurulhuda Elly Soraya , Wilestari Median , Sukamto Heri , Waskito Meindro
Published: July 2024

Penelitian ini bertujuan untuk mengetahui peran variabel GAP dalam memoderasi pengaruh suku bunga The Fed terhadap net interest margin dan dampaknya terhadap profitabilitas. Sampel penelitian yakni bank umum konvensional persero terdiri dari Bank Mandiri, Bank BNI, Bank BRI, dan Bank BTN berdasarkan data deret waktu secara bulanan dari Januari 2022 hingga Desember 2023, dengan teknik pengumpulan datanya adalah dokumentasi dari sumber Statista, Bank Indonesia, dan Otoritas Jasa Keuangan. Teknik analisis data menerapkan Parsial Least Square/PLS. Hasil penelitian menemukan suku bunga The Fed tidak berpengaruh terhadap net interest margin. GAP berperan memoderasi pengaruh suku bunga The Fed terhadap net interest margin. Net interest margin tidak berpengaruh terhadap profitabilitas
INDUSTRI HALAL: PARADIGMA TAUHID MEWUJUDKAN RANTAI NILAI HALAL DI INDONESIA
Authors: Bawafie Aniq Akhmad Ali , Tompson Muhammad Danial , Muin Rahmawati
Published: July 2024

Menurut paradigma Tauhid, bisnis dan individu yang mengandalkan harga halal bertujuan untuk meningkatkan integritas, akuntabilitas, dan transparansi dalam transaksi mereka. Filosofi ini mendorong pendekatan holistik terhadap etika bisnis, memungkinkan pertumbuhan ekonomi tanpa mengabaikan adab-adab agama serta akhlak. Penelitian ini memakai desain kualitatif dengan jenis studi dokumentasi yang bersifat deskriptif analitis. Tujuan utamanya adalah untuk menggambarkan dan mendeskripsikan bagaimana paradigma Tauhid berkontribusi dalam pembentukan rantai nilai halal di Indonesia. Rantai nilai halal merupakan kepingan dari rencana dalam sektor perusahaan halal di Indonesia, bertujuan melindungi dan membentengi kehalalan produk yang sampai ke konsumen, terutama dalam kategori makanan dan minuman. Kegiatan ekonomi seperti distribusi, produksi, konsumsi, ekspor, serta impor didasarkan pada prinsip tauhid dan batas-batas Syariah, dengan tujuan menciptakan falah (kesejahteraan) untuk menyenangkan Allah. Tauhid yang kuat akan menghasilkan moralitas yang baik dalam semua aspek, termasuk ekonomi. Tauhid adalah inti dari pandangan dunia Islam, yang mendeklarasikan bahwa alam raya diciptakan oleh Allah dengan tujuan yang jelas. Manusia diciptakan sebagai khalifah Allah di bumi, serta sumber daya alam harus digunakan untuk kemakmuran umat manusia. Pandangan ini menolak konsep kepentingan pribadi dalam kapitalisme dan mendorong persaudaraan universal serta kesetaraan sosial.
Kata kunci: Tauhid, Rantai Nilai Halal, Industri Halal
ANALISIS EFEKTIFITAS DJP ONLINE DALAM PEMBUATAN BUKTI POTONG (E-BUPOT) PADA PPH 21
Authors: Zumariz Iyaza , Ratnawati Dyah
Published: July 2024

Penelitian ini bertujuan untuk menganalisis efektivitas sistem DJP Online dalam pembuatan Bukti Potong (e-Bupot) pada Pajak Penghasilan (PPh) 21. Metode penelitian melibatkan pengumpulan data dari berbagai sumber terkait implementasi e-Bupot oleh Direktorat Jenderal Pajak (DJP). Hasil analisis menunjukkan bahwa DJP Online telah berhasil meningkatkan efisiensi dalam proses pembuatan e-Bupot dengan mempercepat dan menyederhanakan proses tersebut. Penerapan teknologi ini juga memberikan kontribusi signifikan terhadap peningkatan akurasi data dan kepatuhan perpajakan. Keberhasilan DJP dalam mengimplementasikan e-Bupot tidak hanya memperbaiki layanan kepada wajib pajak, tetapi juga mengoptimalkan penggunaan sumber daya dengan efisien. Namun demikian, masih ada tantangan yang perlu diatasi, seperti perlindungan terhadap keamanan data dan pemeliharaan keandalan sistem secara berkelanjutan. Penelitian ini memberikan rekomendasi untuk terus memperbaiki infrastruktur teknologi informasi dan mengintensifkan pelatihan terkait kepada staf DJP guna memastikan keberlanjutan dari keberhasilan implementasi e-Bupot.
Perfil de morbimortalidade por câncer de boca e orofaringe em Montes Claros – MG no período de 2008 a 2018
Authors: Gonçalves Jaqueline Teixeira Teles , Vieira Kássia Héllen , Gonçalves Camila Teles , Santana Renata Ferreira , Prince Mateus Augusto de , Silva Yan Lucas Martins , Borges Michelle Aparecida Ribeiro , Prince Karina Andrade de
Published: July 2024

Introdução: Neoplasias malignas que afetam a cavidade oral e a orofaringe representam um problema de saúde pública. Sua incidência e prevalência é alta sendo consideradas de elevada mortalidade, podendo variar de região para região do Brasil. Objetivo: Caracterizar o índice de internações e óbitos por câncer de boca e orofaringe no município de Montes Claros (MG) entre 2008 e 2018. Material e Métodos: Estudo retrospectivo, transversal, de delineamento quantitativo. O universo da pesquisa foi a base de dados do Sistema de Informações Hospitalares do Sistema Único de Saúde referente à taxa de internações e óbitos por câncer de boca e orofaringe no município de Montes Claros, no período de 2008 a 2018. Resultados: Foram registrados 2.460 casos de internações e uma média de 224 por ano. Houve predomínio do sexo masculino (76,1%), entre a faixa etária de 50 a 69 anos (55,9%), pardos (76,9%), internados em caráter de urgência (65,1%), em regime privado (68,7%), com média de permanência maior no regime público (11,4 dias). O setor privado é responsável por maior parte dos gastos: 5,54 milhões de reais (55,5%). A taxa média de mortalidade por câncer de boca e orofaringe foi de 7,85%, sendo que foi maior no sexo masculino, mais expressiva em pacientes com idade 0 a 9 anos (16,67%) e acima dos 80 anos (13,48%). Conclusão: Ao avaliar, as taxas de internações e óbitos por câncer de boca e orofaringe no município de Montes Claros (MG) no período analisado, verificou-se que o público masculino é o mais atingido, tanto em termos de diagnóstico deste tipo de condição clínica quanto em taxas de internação e mortalidade.
Effect of fructose on the intestinal microbiota: a systematic review of randomized clinical trials
Authors: Silva Letícia Lourenço da , Lopes Rayane  Rodrigues , Guilarducci Mariana Julião , Coelho Olívia Gonçalves Leão , Cândido Flávia Galvão , Guimarães Nathalia Sernizon , Gomes Júnia Maria Geraldo
Published: July 2024

Background: Preclinical data suggest that at least part of the harmful effects of excessive fructose consumption are due to alterations in the intestinal microbiota, which may be associated with a number of metabolic diseases, such as diabetes mellitus, obesity, inflammatory bowel disease, metabolic syndrome, and non-alcoholic fatty liver disease. Objective: The aim of this systematic review is to evaluate the effects of fructose consumption on the human intestinal microbiota. Methods: A systematic search was carried out in electronic databases: MEDLINE, Embase, and Cochrane Library without restriction to a year of publication and language. Inclusion criteria were primary articles that evaluated the effect of fructose consumption on the human intestinal microbiota. Results: Five randomized clinical trials were include. It was observed that the composition of the human intestinal microbiota seems to be altered differently in response to fructose consumption at distinct sources and concentrations. Overall, fructose administration increased bacterial profile associated with inflammation, hepatic steatosis, butyrate production, and inhibition of microbial aerobic respiration in the ileum (Proteobacteria, Actinobacteria, Anaerostipes, and Faecalibacterium). The administration of fructose showed a negative correlation for Firmicutes and a positive correlation for Parabacteroides in relation to total cholesterol and LDL-c. However, studies had great methodological heterogeneity and presented high risk of bias. Conclusion: Fructose administration affects the composition of human intestinal microbiota. More studies are needed to reach definitive conclusions.
Estado cognitivo do idoso não institucionalizado num distrito no Norte de Portugal
Authors: Brás Manuel Alberto Morais , Machado Dora Margarida Ribeiro , Condado Andreia Isabel Costa , Fernandes Hélder Jaime
Published: July 2024

Introdução: O fenômeno do envelhecimento aumenta a probabilidade e a durabilidade de doenças crônicas, incapacidades e situações de dependência física, psíquica e social. Frequentemente são reportadas alterações mentais e cognitivas associadas ao processo de envelhecimento, tanto por profissionais de saúde como pelos próprios idosos. Objetivo: Identificar a prevalência de alterações cognitivas em idosos não institucionalizados de um distrito do Norte de Portugal, relacionando o seu estado cognitivo com variáveis sociodemográficas, avaliação sensorial, hábitos de vida, estado de saúde e estado afetivo (depressão). Material e Métodos: Investigação de metodologia quantitativa, estudo observacional, descritivo, analítico de coorte transversal, com uma amostra por conveniência. Para recolha de dados, foi utilizado um formulário composto por um questionário sociodemográfico, profissional e clínico, pela Mini Mental State Examination (MMSE), para avaliar o declínio cognitivo, e pela Geriatric Depression Scale (GDS-15), para avaliar sintomas depressivos. Resultados: A amostra foi constituída por 581 idosos residentes no distrito em análise, sendo maioritariamente do sexo feminino (85,9%), sem comprometimento cognitivo (99,3%) e sem depressão (81,1%). O estado cognitivo dos idosos não institucionalizados diferiu em função da idade (p<0,001), sexo (p= 0,020), habilitações literárias (p<0,001), profissão (p<0,001), problemas de visão (p<0,001) e audição (p<0,001), perda auditiva (p<0,001), consumo de tabaco (p= 0,012), consumo de álcool (p= 0,045), polimedicação (p<0,001) e recurso a auxiliares de marcha (p<0,001). A saúde autopercebida (p<0,001) e a condição afetiva (depressão) (p<0,001) também influenciaram o estado cognitivo dos idosos em análise. Conclusão: Os resultados indicaram, de forma geral, a ausência de comprometimento cognitivo e de sintomas depressivos nos inquiridos. Foi observado que quanto maior o nível educacional, melhor o desempenho cognitivo; quanto mais avançada a idade, pior o estado cognitivo; uma autopercepção positiva em relação à saúde associou-se a um melhor estado cognitivo; e a presença de sintomas depressivos teve um impacto negativo no estado cognitivo.
Freud e a fralda: o desfralde como um rito de passagem
Authors: Schmidt Lucélia Paula  Cabral , Grunewald Sabrine Teixeira Ferraz , Schmidt Eder
Published: July 2024

Introdução: Diversos autores afirmam a influência de fatores fisiológicos e psicológicos no aprendizado do controle esfincteriano, destacando a aquisição desse controle como um marco de desenvolvimento da criança, envolvendo habilidades físicas e de relacionamento com o meio. Entretanto, propõe-se que o desfralde seja também um rito de passagem, uma resposta adaptativa obrigatória ao indivíduo quando forçado a mudar de posição dentro de um sistema. Objetivo: Destacar as dimensões social e cultural na aquisição do controle esfincteriano, um processo cujas inadequações estão incluídas entre os preditores para sintomas urinários e constipação na infância. Materiais e Métodos: O trabalho foi desenvolvido por meio de pesquisa bibliográfica realizada a partir dos temas “ritos de passagem” e “estágio anal do desenvolvimento psicossexual pela ótica freudiana”. Não foram aplicadas restrições por idioma, nacionalidade ou ano de publicação nos textos selecionados. Resultados: Constatou-se que na operação do desfralde, para além da dimensão fisiológica estão em jogo importantes fatores estruturantes do psiquismo e das relações sociais. Propõe-se a inclusão do desfralde na série de mudanças de status em que o indivíduo se vê implicado em sua relação com a sociedade. Além do aprendizado de um hábito, ocorre também uma importante passagem no curso do desenvolvimento mental e social da criança, estando em jogo a decisão entre satisfazer-se de forma livre ou ceder a condicionantes socioculturais para essa satisfação. Conclusão: Considerando o processo de aquisição do controle esfincteriano como uma metáfora do processo de internalização de códigos socioculturais, é possível a caracterização do desfralde como um rito de passagem.
The Significance of Public Relations Roles in Enhancing Social Responsibility in Commercial Chamber Institutions in the West Bank
Authors: Abu-Lebdeh M
Published: July 2024

This study aims to uncover the significance of public relations roles in promoting social responsibility in commercial chamber institutions in the West Bank. The study adopted a descriptive-analytical methodology. The study population consists of employees in commercial chamber institutions in the West Bank. A sample of (100) employees is selected through a questionnaire containing (5) axes and (25) statements. The study reached several key findings: employees' awareness of the concept and dimensions of corporate social responsibility within commercial chamber institutions in the West Bank is significantly high. Moreover, public relations contribute to improving relationships and work atmospheres within these institutions, in addition to being highly effective in achieving goals such as enhancing reputation, public image, and gaining external public satisfaction. The results also indicate that public relations engage in various activities aimed at promoting corporate social responsibility, such as supporting charitable works, small projects, community programs, and cultural initiatives, while also contributing to internal public satisfaction through strengthening bonds, material motivation, and assuming full responsibility towards them. Consequently, the study recommends conducting awareness workshops for public relations employees on how to embody the dimensions of corporate social responsibility in various activities and programs, as well as supporting senior management in public relations activities.
Impact of COVID-19 on the use of project management methods, tools, and techniques in the construction sector in the Auckland region
Authors:   , Leksani Rudina
Published: July 2024

The construction sector plays a significant role in New Zealand’s economic growth, making a substantial contribution to the nation's gross domestic product and employment rates. Witnessing the Coronavirus (COVID-19) pandemic shortly after its outbreak in November 2019, the construction sector faced significant challenges. This research examined the impact of COVID-19 on project management methodologies, tools, and techniques used in Auckland, New Zealand’s construction sector, providing practical insights for stakeholders, policymakers, and project management professionals, crucial for informing effective responses and strategies. This research employed qualitative methods, using ten semi-structured interviews conducted with participants selected through probability purposive sampling, specifically targeting project managers and construction professionals. Thematic analysis identified six themes and 23 sub-themes. The impact of COVID-19 on project management practices was substantial, particularly in terms of disrupting traditional Waterfall methods. Agile and hybrid methods, on the other hand, proved greater adaptability in response to the challenges brought by COVID-19. Key drivers of change in project management practices included remote working policies, supply chain disruptions, and skilled labour shortages. Practical implications for the construction sector involved optimising methodologies with a mix of Waterfall, Agile, and hybrid methods. In response to the COVID-19 challenges, stakeholders are implementing robust risk management strategies, building a resilient and diversified supply chain through collaborating with suppliers, and addressing skilled labour shortages through training and upskilling initiatives to improve project efficiency.
Tradiciones zoológicas y antropomorfismo crítico en El rey gallo y discursos de la hormiga (1671): ¿un ejemplo de “sátira de especie”?
Authors: Rodríguez García Miguel
Published: July 2024

En este trabajo se lleva a cabo una lectura animalista de El rey gallo y discursos de la hormiga (1671), de Francisco Santos. Por un lado, esta investigación descubre nuevas fuentes zoológicas (fabulísticas, naturalistas, folclóricas…) que no habían sido indicadas por la crítica hasta la fecha y que operan tanto en la construcción del carácter de los protagonistas como en las abundantes digresiones y cuentos interpolados en la obra. Por otra parte, destacamos el uso del antropomorfismo en el texto en calidad de instrumento para la crítica del ser humano y de su ingratitud hacia otros seres vivos, así como varios pasajes que remiten al trato que recibían ciertas especies en la época áurea. Finalmente, nos planteamos la pertinencia de considerar los últimos tres cantos de El rey gallo y discursos de la hormiga como un caso de “sátira de especie”, en la que el hombre es amonestado por su modo de disponer de los demás animales.
Kajian Semiotika Ruang Pada Masjid Gedhe Kauman – Yogyakarta
Authors: Falahi Yusron , Saidi Acep Iwan
Published: July 2024

Bangunan Masjid Gedhe merupakan sebuah representasi kehidupan masyarakat jawa yang selalu berpegang teguh terhadap budaya yang identik dengan unsur keseimbangan. Oleh karena itu, perlu untuk mengungkap makna dan signifikansi dalam arsitektur Masjid Gedhe sehingga tidak hanya dipandang sebagai bangunan fisik, tetapi juga sebagai simbol yang mengkomunikasikan nilai-nilai keagamaan dan budaya Islam. Dengan menggunakan Semiotika Ruang untuk mengkaji bangunan Masjid Gedhe, terutama fokus pada fasad dan ruang utama. Melalui metode ini, aspek-aspek arsitektur, dekorasi, tata letak, dan penggunaan ruang diinterpretasikan sebagai simbol-simbol yang menyampaikan pesan keagamaan, budaya, dan sosial. Kesimpulan penelitian menunjukkan bahwa Masjid Gedhe mencerminkan makna filosofis budaya Jawa yang dipadukan dengan ajaran Islam, terutama dalam struktur ruang dan fungsi-fungsi simbolisnya. Ruang-ruang seperti liwan, serambi, dan regol mencerminkan signifikasi dalam praktek keagamaan dan interaksi sosial di dalam masjid. Ini menunjukkan bahwa melalui kajian Semiotika Ruang, Masjid Gedhe dapat dipahami sebagai medium yang menggabungkan nilai-nilai budaya dan agama dalam satu wadah fisik yang sama, mencerminkan perpaduan harmonis antara dua tradisi yang penting dalam kehidupan masyarakat Yogyakarta. Penelitian ini memberikan wawasan baru tentang bagaimana elemen-elemen arsitektur Masjid Gedhe Kauman berfungsi sebagai simbol yang menyampaikan pesan-pesan religius dan budaya, sehingga memperdalam pemahaman tentang peran ruang dalam menghubungkan aspek fisik dan spiritual dalam arsitektur Islam.
Perancangan Buku Ilustrasi Sebagai Sarana Edukasi dan Dukungan Sosial Terhadap Penderita Skizofrenia
Authors: Bentri Swesti Anjampiana , Noviadji Benny Rahmawan , Kristiawan Samuel Indra
Published: July 2024

Gangguan kejiwaan dapat dapat dialami setiap orang dan mengakibatkan gangguan cara berpikir, merasa, perilaku dan interaksi. Skizofrenia adalah gangguan jiwa berat yang bersifat kronis. dimana penderita mengalami kesulitan untuk membedakan antara realita dan delusi atau waham maupun halusinasi yang dialami. Saat ini masih banyak yang belum memahami tentang skizofrenia, sehingga memerlukan media untuk mengenalkan atau mengedukasi tentang skizofrenia. Berdasarkan permasalahan tersebut, maka dilakukan perancangan media edukasi akan pentingnya dukungan sosial terhadap penderita skizofrenia berupa buku ilustrasi yang ditujukan kepada kalangan remaja hingga dewasa. Tujuan karya ini adalah agar mereka sebagai orang terdekat dapat memahami apa itu skizofrenia dan bagaimana menanganinya. Proses perancangan dimulai dari riset data melalui wawancara dengan seorang psikiater. Selain itu juga melalui observasi terhadap salah satu penderita. Pengumpulan data sekunder didapatkan dari beberapa sumber seperti buku, jurnal dan artikel. Proses pembuatan karya dimulai dari penyusunan materi buku, desain karakter, sketsa, layout. Hingga dihasilkan karya berupa buku ilustrasi berisi 60 halaman sebagai media utama. Melalui perancangan buku ilustrasi ini diharapkan kalangan remaja dan dewasa dapat lebih memahami skizofrenia dan penangannanya, sehingga memberikan dampak positif bagi penderita untuk bisa berfungsi dengan baik dalam kehidupan.
Comparative Analysis of Technological Indicators Development Regions of the Volga Federal District
Authors: Казакова О.Б.
Published: July 2024

В статье рассмотрены ключевые характеристики технологического развития и на основе мирового опыта выделены его основные тенденции. Проведен сравнительный анализ некоторых показателей технологического развития регионов ПФО, позволивший обозначить позицию каждого из них в обеспечении технологических изменений, направленных на выпуск высокотехнологичной продукции, востребованной рынком. Полученные результаты могут быть положены в основу мероприятий по активизации кооперационного и интеграционного взаимодействия в межрегиональном пространстве.

The article discusses the key characteristics of technological development and, based on international experience, highlighted its main trends. A comparative analysis of some indicators of the technological development of the regions of the Volga Federal District was carried out, which made it possible to indicate the position of each of them in ensuring technological changes aimed at producing high-tech products demanded by the market. The results obtained can be used as a basis for measures to enhance cooperation and integration interaction in the interregional space.
Efficacy of New Oral Anticoagulants Compared to Warfarin in Different Age Groups of Patients with Atrial Fibrillation: A Literature Review
Authors: Кармильцына А.М. , Куксенко Ю.А. , Бутолина Ю.К. , Хечумян А.Г. , Елисеев А.В.
Published: July 2024

Фибрилляция предсердий (ФП) значительно увеличивает риск тромбоэмболических осложнений, особенно инсульта, что делает антикоагулянтную терапию критически важной для предотвращения данных осложнений. В статье подробно рассматривается ФП, наиболее частая устойчивая форма аритмии, представляющая собой значительную проблему для общественного здравоохранения глобального масштаба. Сосредоточиваясь на данных о частоте новых случаев ФП за период с 2009 по 2022 г., исследование анализирует возрастные характеристики пациентов при первичном скрининге. Объектом изучения стала группа из 8429 человек в возрасте от 45 до 69 лет, не сталкивавшихся до этого с сердечно-сосудистыми заболеваниями и ФП. В ходе исследования было обнаружено, что с увеличением возраста пациентов риск развития ФП значимо возрастает. Также проведено сравнение традиционных антикоагулянтов, включая варфарин, с новыми оральными антикоагулянтами (НОАК). Основываясь на данных из крупных клинических исследований, анализируется эффективность, безопасность и воздействие на качество жизни пациентов обеих групп препаратов. Результаты подтверждают, что НОАК обладают лучшим профилем эффективности и безопасности по сравнению с варфарином, предлагая важные преимущества, включая уменьшенный риск серьезных кровотечений и улучшение качества жизни пациентов. Полученные данные и выводы могут послужить для разработки стратегий общественного здравоохранения и предложения целевых мер профилактики, адаптированных к возрастным группам, наиболее подверженным риску.

Atrial fibrillation significantly increases the risk of thromboembolic complications, especially stroke, making anticoagulant therapy critically important for preventing these complications. This paper provides a detailed examination of atrial fibrillation (AF), the most common persistent form of arrhythmia, representing a significant global public health issue. Focusing on data regarding the incidence of new AF cases from 2009 to 2022, the study analyzes the age characteristics of patients at initial screening. The subject group consisted of 8,429 individuals aged 45 to 69 years who had not previously encountered cardiovascular diseases and atrial fibrillation. The research found that the risk of developing AF significantly increases with patient age. A comparison of traditional anticoagulants, including warfarin, with new oral anticoagulants (NOACs) was also conducted. Based on data from major clinical trials, the efficacy, safety, and impact on patients’ quality of life of both drug groups are analyzed. The results confirm that NOACs possess a better efficacy and safety profile compared to warfarin, offering significant advantages, including a reduced risk of serious bleeding and improved quality of life for patients. The findings and conclusions can serve in the development of public health strategies and the proposal of targeted prevention measures, adapted to age groups most at risk.
METHODOLOGY FOR NON-INVASIVE MONITORING OF INTRACRANIAL PRESSURE WAVES IN DOGS WITH TRAUMATIC BRAIN INJURY USING THE BRAIN4CARE® BCMM/2000 MONITOR
Authors: Weizenmann Thyara , Bahr Arias Mônica Vicky
Published: July 2024

Invasive intracranial pressure (ICP) monitoring is performed in humans to identify and manage intracranial hypertension (ICH) early. However, its use in veterinary medicine remains limited due to the cost and risk of complications, prompting ongoing research to non-invasive alternatives. Recently, a non-invasive ICP monitoring device (PIC-Ni) was released on the market and has already been used in humans, rats and dogs. Although the technique has been described in dogs, there are some difficulties in carrying out the procedure. Thus, this study aims to detail the methodology employed in monitoring ICP-Ni using the Brain4care® BcMM2000 monitor in dogs with traumatic brain injury. Conducted as a prospective case series at a Veterinary Teaching Hospital between May 2019 and December 2020, the study involved 11 dogs with cranioencephalic trauma. Efforts were made to ensure a calm environment. Unlike in humans, in which the sensor is placed on the head with an adjustable band, in dogs the sensor is used with the aid of a stereotaxic support, thus requiring patients to remain still for a few minutes. Although successful ICP-Ni waveform monitoring was achieved in all cases using this methodology, eight dogs required procedure repetition due to artifacts, and five dogs needed sedation. Despite positive outcomes, the encountered challenges suggest the need for device modification by the company to enhance its usability in dogs.
A Computer Laboratory for the Calculation of the Heat Capacity of a Peptide Unfolding Transition
Authors: Grøndahl Lau Blom , Schuhmann Fabian , Bruhn Dennis , Dubey Vikas , Solov’yov Ilia A. , Khandelia Himanshu
Published: July 2024

We present the implementation of a computer simulation laboratory for the calculation of the heat capacity of the folding-unfolding pseudo phase transition of a polyalanine Ala30 α-helix, using molecular dynamics simulations. Unlike conventional calorimetry experiments, which provide a macroscopic interpretation of the heat capacity, the computer laboratory additionally offers a molecular perspective of the energy exchange processes that lead to the peak of the heat capacity at the phase transition, as well as the statistical mechanical interpretation of the phase transition. The exercise is targeted toward 1st- or 2nd-year students of biophysics in the context of an undergraduate physical chemistry course. We use a graphical web interface to overcome the steep learning barriers associated with command line interactions in commonly used molecular dynamics protocols. The web interface (VIKING) also handles communication with computing hardware in the background, so that students with limited or no programming experience can launch and analyze the simulations easily. A collaboration between the VIKING support team and responsible teachers is required to set up VIKING. We also present a solution in which simulations can be launched on students’ own computers, if some command line knowledge can be expected. The laboratory can also be repurposed for students of various backgrounds (physics, chemistry, biology, or engineering) and scholastic levels (undergraduate or graduate).
Cuerpo y género en la formación de jóvenes del Liceo Policial Crio. Gral. Jorge Vicente Schoo de la provincia de Buenos Aires
Authors:   , Barreneche María Luz
Published: July 2024

¿Cuál es la mirada de diferentes actores del Liceo Policial Crio. Gral. Jorge Vicente Schoo acerca de la relación Cuerpo y Género en la formación? ¿Qué prácticas corporales se llevan adelante en la Escuela Secundaria de la Policía Bonaerense? La perspectiva de Comunicación/ Educación resulta clave para comprender los procesos que se desencadenan en esta instancia formativa. Asimismo, en articulación con el campo del Lenguaje Corporal, es posible realizar un aporte a los estudios de Cuerpo y Subjetividad. Indagar acerca de estas cuestiones en la mirada de los docentes y tutores del Liceo Policial Crio. Gral. Jorge Vicente Schoo entiende una vacancia que este trabajo aportará al campo. Se incorporan nuevas miradas que requieren ser pensadas en relación a la perspectiva de género. - Identificar al campo Comunicación/Educación en su rasgo educativo institucional para recuperar puntos nodales desde donde pensar la intervención escolar. - Presentar la dinámica de la escuela secundaria Liceo Policial Crio. Gral. Jorge Vicente Schoo y revelar las distintas corrientes y perspectivas de articulación Cuerpo/Género y Formación de Jóvenes desde la mirada de los diferentes docentes y tutores que conforman la institución. - Develar corrientes alternativas sobre cuerpo, subjetividad y género que resulten en nuevos discursos político-institucionales que alienten a pensar en nuevas “identidades policiales”. - Trazar consideraciones finales entre los conceptos incorporados desde la Maestría en Comunicación/Educación y la práctica docente en la institución secundaria Liceo Policial Crio. Gral. Jorge Vicente Schoo, producciones y contradicciones, sobre todo desde el punto de vista de los actores de la institución. - Presentar el trabajo etnográfico de campo a partir de las entrevistas completas, descritas en los anexos.
Determinants of Agency Costs: Evidence from Jordan
Authors: Alsaraireh Ahmad
Published: July 2024

This study examines the impact of firm characteristics, namely size, leverage, profitability, and growth on the asset turnover ratio, which inversely measure the firm’s agency costs. Using data about non-financial firms listed on the Amman Stock Exchange, the results of the Generalized Method of Moments) GMM) estimator show that leverage, profitability, and growth are positively related to asset turnover, suggesting that firms with higher leverage ratios, profitable firms, and firms with higher investment opportunities experience lower agency costs compared to their counterparts. However, this study finds no evidence on the impact of firm size on asset turnover. Finally, this study finds that managers of Jordanian firms set a target level of agency costs and attempt to gradually adjust the agency cost level towards that target. Results of this study are of high importance for firms’ managers and policy makers as it sheds light on the important factors that affect the agency costs of these firms.
Gender Faces In The Textbook Of Al-Arabiyah Li Al-Nasyi’in (Critical Discourse Analysis Study)
Authors: Shifany Maulida  , Razik Insani  , Ahmad Royani  , Achmad Fudhaili
Published: July 2024

The polemic of gender equality and justice in its status and role in society is one of the studies that is often echoed to this day. Polemics over gender equality can be found in various fields, one of which is in the field of education, especially in the learning media, namely textbooks. The purpose of this study is to describe how the discourse or text in the book al-Arabiyah li al-Nasyi'in Volume 2 by Mahmud Ismail Shini reflects the construction and division of gender roles performed by women and men, as well as the impact on readers' understanding of gender roles based on the subject-object position and the position of the author-reader of Sara Mills' theory in the textbook. The data of this research are texts that contain gender perspectives from the textbook al-Arabiyah li al-Nasyi'in Volume 2. The method used in this research is library research. The results of this study are the form of gender bias in the subject-object position is subordination and stereotyping of women, and the form of gender bias in the position of the author-reader is indirect addressing done by means of cultural codes, and direct by using third-person singular pronouns.
A Community-Engaged Approach to Reducing Barriers to Breast and Cervical Cancer Screening: The Use of Mapping Tools
Authors: Moyce Sally , Comey Danika , Claudio David , Velazquez Maria , Chavez Reyes Genesis , Aghbashian Elizabeth
Published: July 2024

Visual tools such as diagrams and mapping are effective research methods that help engage the community in the process and encourage active participation in generating potential solutions to a complex health problem. In participatory research, these methods help bridge potential communication gaps between community partners and academics. We present the steps we undertook to evaluate barriers to completing recommended breast and cervical cancer screenings. We engaged a community advisory board (CAB) of women who had been enrolled in the National Breast and Cervical Cancer Early Detection Program to investigate barriers to receiving recommended screenings and to brainstorm potential solutions to address the barriers. We describe the tools we used in the process: fishbone diagrams, mind mapping, and concept mapping. We were able to identify and categorize potential solutions to increase screening rates under four themes: 1) communication; 2) scheduling; 3) transportation; and 4) providers. Real-time updates and feedback loops facilitated by these tools create a continuous dialogue between researchers and community partners, which strengthens the relationship between academic and community collaborators and ensures that the research remains responsive to the evolving dynamics of the community.
Community-Led Solutions: How Local Organizing Committees Drive Change for Housing and Health Equity in California’s Central Valley
Authors: Martinez Rebecca L. , Frausto David , Zavala-Sandoval Juan , Serna Anabel , Corchado Claudia G. , Alvarado Alexandra , Nkosi Janine , Yen Irene
Published: July 2024

In this research brief, we describe how the HOPe Lab (UC Merced), Faith in the Valley (Fresno), and Cultiva Central Valley (Merced) are collaborating to address housing-related disparities within California’s culturally diverse Central Valley. Focused on the transformative role of Local Organizing Committees (LOCs), our research employs an anti-racist research praxis to actively engage residents, enhance leadership capacity, and foster communication between residents and elected officials. Drawing on several theory-of-change statements and the practical insights gained from “field experts” carrying out ongoing initiatives, this report explores the positive impact of LOCs on meaningful community involvement, empowerment, engagement, accountability, and policy changes.
The NCCB Case Example: Reflections on a Successful Fourteen-Year CBPR Partnership
Authors: Jemal Alexis D. , Benoit Ellen , Thompson Shola , Jones Heather A. , Windsor Liliane , Lassiter Teri , Thompson Warren , The NJ Critical Consciousness Collaborative Board (3CB)
Published: July 2024

The Newark Community Collaborative Board (NCCB) is in its fourteenth year of operation with nine successful research projects and more than six million dollars in funding. The NCCB began with a community needs assessment in Newark, New Jersey, that led to the subsequent establishment of a community collaborative board (CCB) of consumers, researchers, service providers, and residents committed to advocating for health equity through community engagement and research informed by critical thinking. This paper explores the NCCB’s history and processes that allowed conducting community-based participatory research (CBPR) to reduce inequities related to social determinants of health (SDH). This conceptual manuscript draws on data from NCCB meeting minutes and a group interview with three of the five founding members. We detail the collaborative process used to develop and assess Community Wise, a multilevel, group-based intervention designed to reduce substance use among formerly incarcerated men in Newark, funded by the National Institutes of Health. Review of documentation and interview transcripts revealed the following key ingredients for success: 1) Having a north star; 2) Functional diversity; 3) Challenges as learning opportunities; 4) Board structure and healthy relationships; and 5) Funding and resources. The NCCB has undergone multiple transformations, including a name change to the New Jersey Critical Consciousness Collaborative Board (NJ-3CB), representing its growth from being a small local board to becoming part of a network of community collaborative boards across the United States and a chapter of the global campaign against racism. These and future transitions will help sustain the collaborative journey.
Engaging New Yorkers in Discussion Around Segregated Health Care: The Health Equity and Access to Care (HEAC) Project
Authors: Romero Diana , Weckesser Samantha , Jackson Jenai , Ayedun Adeola , Maru Duncan
Published: July 2024

The Health Equity and Access to Care (HEAC) project was a community-engaged research project that involved focus groups (n=35) and key informant interviews (n=9) designed to examine healthcare segregation in New York City (NYC). The project utilized a multi-faceted community-engaged approach that involved stakeholders from four different sectors (municipal institutions, civil society groups, academic/research and business entities) to recruit a diverse, broad-based sample of New Yorkers who accessed care within a year of participating in the study. We employed a phased information dissemination and outreach strategy allowing for a wide range of ways that community members from different groups could contribute to the project, through both recruitment and participation. In this report we demonstrate our broad conceptualization of “community” and the specific means for implementing a community-engaged project on health equity to ensure participation by a diverse sample. We describe successes and challenges confronted in generating a sample of participants who could contribute insights and experiences related to access to care in a segregated healthcare system.
Relationships, Reflection, and Response: An Iterative Collaborative Research Process to Address Mental Health inequities.
Authors: Dutt Anjali , Blessett Brandi , Wright Bryan
Published: July 2024

The authors share insights about methodology learned through a three-year (and counting) community-based participatory research (CBPR) process centered on enhancing the mental health of Bhutanese youth in Cincinnati, Ohio. We will illustrate how we collaboratively designed, paused, responded to community and societal concerns, redesigned, and enacted our research goals through multiple iterations, and explain how others might use this process in their own research. By uniting community organizations, university researchers, and the support of Robert Wood Johnson Interdisciplinary Research Leaders we are using this deeply iterative process to address the implications of global and local racism and address mental health inequities. We end with specific suggestions for how researchers can learn from our experiences to enhance the potential for future research to support social justice.
Total polyphenol, flavonoid content and antioxidant activity of two species with ethnopharmaceutical uses from the spontaneous flora of the Oltenia region, Romania
Authors: Tănasie Eliza Stefania , Nanescu Valentin , Amzoiu Emilia , Amzoiu Manuel Ovidiu , Mocanu Andreea Gabriela , Ciulu-Costinescu Felicia , Chirigiu Liviu
Published: July 2024

In the conducted study, we investigated the total phenolic content of the alcoholic extracts from various vegetative organs of two plants of Romanian wild flora, Oltenia region: Dipsacus laciniatus and Armoracia rusticana. The antioxidant activities were determined by ferric reducing antioxidant power (FRAP), and 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging methods. We also determined total polyphenol and flavonoid content. The results showed significant differences among plant various vegetative organs, the highest content of polyphenols being found for the leaves extract of Dipsacus laciniatus species, followed by Armoracia rusticana leaves. The highest antioxidant reducing power was obtained for the Armoracia leaf extract (IC50= 101.94 µg/ml), followed by the leaves of Dipsacus (IC50= 77.86 µg/ml).
PENERAPAN METODE SUPPORT VECTOR MACHINE DALAM CLASSIFIKASI ULASAN PENGGUNA APLIKASI MOBILE JKN
Authors: Sugihartono Tri , Putra Rendy Rian Chrisna
Published: July 2024

Aplikasi JKN Mobile telah menjadi salah satu sarana utama bagi masyarakat Indonesia untuk mengakses layanan kesehatan yang disediakan oleh program Jaminan Kesehatan Nasional (JKN). Dalam konteks ini, analisis sentimen ulasan pengguna aplikasi JKN Mobile menjadi penting untuk memahami persepsi dan pengalaman pengguna. Dalam penelitian ini menggunakan metode klasifikasi SVM untuk melakukan analisis sentimen secara mendalam terhadap ulasan pengguna aplikasi JKN Mobile. Langkah-langkah penelitian meliputi pengumpulan data ulasan pengguna, preprocessing data, ekstraksi fitur, pembagian data, pelatihan model SVM, dan evaluasi kinerja model. Data ulasan pengguna dikumpulkan dan diproses, lalu dilatih menggunakan model SVM untuk mengklasifikasikan sentimen ulasan menjadi positif, negatif, atau netral. Penelitian ini melakukan pengujian tingkat akurasi dengan perbandingan pembagian data training dengan data testing. Tujuan dari metode ini adalah untuk mengeksplorasi berbagai teknik optimasi untuk meningkatkan akurasi model SVM dalam klasifikasi sentimen ulasan pengguna aplikasi JKN Mobile. Ini bisa mencakup penggunaan algoritma optimasi seperti Particle Swarm Optimization (PSO) untuk menemukan parameter terbaik bagi model SVM. Hasil penelitian menunjukkan  Tingkat akurasi SVM setelah penerapan PSO atau Grid Search mengalami peningkatan akurasi yang awalnya tingkat akurasi SVM sebesar 81%, setelah optimasi, tingkat akurasi mendapatkan akurasi yang lebih tinggi sebesar 85 %.
PAISAGEM URBANA E SEGREGAÇÃO SOCIOESPACIAL EM ILHÉUS
Authors: Silva de Andrade Érica Dos Santos , Trindade Gilmar Alves
Published: July 2024

A produção do espaço urbano em Ilhéus-BA se dá, historicamente, de forma contraditória e desigual, e a paisagem urbana das zonas Norte e Sul da cidade revela, de imediato, essa contradição; ao norte, territórios das classes populares, majoritariamente; ao sul, territórios mais valorizados para as classes mais abastadas e para a realização dos interesses de ampliação do capital vinculado ao setor imobiliário.  O presente trabalho faz uma breve explanação acerca de como se deu a organização espacial de Ilhéus, uma breve apresentação da organização interna da cidade e como se manifesta a segregação socioespacial que se apresenta na paisagem urbana da cidade. Trata-se de uma pesquisa explicativa, qualitativa e de caráter bibliográfico. A pesquisa contou com a coleta de dados secundários com idas à campo para obtenção de fotografias e preenchimento das fichas de observação acerca dos bairros visitados. Os resultados apresentam que a segregação socioespacial existente na cidade ocorre em função dos modos de apropriação e valorização seletiva do solo urbano pelo capital, na zona sul da cidade; como também devido às disparidades entre a oferta dos serviços e equipamentos urbanos para as áreas mais nobres e para os bairros periféricos.
Una ‘storiografia dei giudici’? Pisa, Lodi, Genova nel XII secolo
Authors: Cotza Alberto
Published: July 2024

Starting from a critical reinterpretation of the debate on the evolutionary lines of lay historiography in the medieval commune, the essay investigates, on the basis of a new analysis of the Gesta Triumphalia per Pisanos facta, the cultural phenomenology and the lines of development of the ‘historiography of judges’ in the 12th century. In particular, the essay highlights, from a comparative perspective, the relevance of the socio-professional segment of judges and legal experts (and not notaries) in the writing of the chronicles of this period. Within this group, the chronicles had a mode of circulation that was neither public nor private, but which can be placed in an intermediate phase that refers to the way in which the authors and the readers used them.