bluuebunny/crossref_metadata_2025 huggingface dataset:
Inclusiveness of Financial Activities of Hotel Institutions during the Covid-19 Pandemic
Authors: Melnychuk Yuliia , Chvertko Liudmyla
Published: December 2022

Scientific work on “Inclusiveness of Financial Activities of Hotel Institutions During the Covid-19 Pandemic” aims to conduct a financial analysis of the state of the hotel services market in Ukraine and the world during the period of active progression of the Covid-19 virus infection. The purpose of the article.  The aim of the work was to study the peculiarities of the financial development of the hotel industry in the pandemic in the world and in Ukraine. The methodology. The totality of research methods is a methodology for analyzing and organizing the main legislative acts and laws, namely the methods of generalization, comparison, chronology, analysis and generalization. Segment diagramming, elements of financial analysis, as a digital display of the state of the economic level of development are used to visualize the state of the hotel business market. The results of the research. The study analyzes the level of change in sales revenue from the hotel business in Ukraine. The regions of Ukraine were divided into the main tourist regions and  the structure of accommodation facilities by types and specialized accommodation facilities have been developed. The scientific work considers the hotel industry as elements of the market of services of Ukraine, so the distribution of accommodation is divided into in the following regions: central region, northern region and western and southern regions. The location of hotel business establishments is appropriately structured. Conclusions that were made indicate the need to improve the quality of services while expanding their range, which is due to the ever-increasing demands of consumers in accordance with the requirements of advanced technologies. A significant expansion of the range of accommodation (apartments, villas, holiday homes, country and guest houses, chalets, etc.) will best guide different groups of tourists and diversify the types of recreation. The presented paper depicts relevant and necessary research that will help hotel business leaders to respond in a timely manner to financial threats. During the Covid-19 pandemic, it is important to monitor the state of the Ukrainian services market, timely implement all possible security measures and prevent the impact of adverse factors on the development of the hotel business.
Heatstroke and brachycephalic dogs – is there an increased risk?
Authors: Ewers Clark Anna
Published: December 2022

PICO question
Do dogs that are brachycephalic have an increased risk for developing heat-related illness compared to dogs that are not brachycephalics?
 
Clinical bottom line
Category of research
Risk.
Number and type of study designs reviewed
Four studies were critically appraised. Three of these were cohort studies, one was a case-control study.
Strength of evidence
Moderate.
Outcomes reported
Brachycephalic dogs are at increased risk of developing heat-related illness and brachycephalic breeds are over-represented in presentations for heatstroke. Other factors named, such as body weight, also contributed to the risk of developing heat-related illness.
Conclusion
Dogs that are brachycephalic are likely to have an increased risk for developing heat-related illness compared to non-brachycephalic dogs.
 
How to apply the evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
An Artistic and Archeological Study of Lakmah Mosque in the Village of Al-Ḥāql, Yāman, Rīmah Governorate – Yemen
Authors: ENAB Mohamed Ahmed Abd ElRahman
Published: December 2022

Lakmah Mosque, which is known as Aḥmad Hādī Al-Yāmani Mosque, is consid-ered one of the distinctive Yemeni mosques that reflects the shape of small cubical mosques in the Yemeni villages. This mosque is distinguished by its distinctive decorations and inscriptions. The research aims to shed light on the personality of the founder of the mosque, as he was one of the important individuals in the history of Rīmah governorate. In addition, the research sheds light on the mosque's style and design. The importance of the research lies in documenting this mosque, its artistic decorations, and its distinctive inscriptions recorded in the magnificent Ṯūluṯ script with its historical information and important cultural content. It also represents the publication for the first time of this mosque, which no one has studied before. The researcher followed the descriptive, analytical and inductive approach through several historical documents and endowment papers. The researcher reached several results, including knowledge of the date of the building of the mosque and knowing the founder's name, and his cultural and historical status, as he is considered one of the prominent political persons in the history of Rīmah governorate during the Ottoman era. The study also focused on the architectural style of the mosque and knowing its architectural origins. The researcher studied the wonderful inscriptions that decorate the ceiling of the mosque. These inscriptions provided us with much important historical information.
Moroccan New Green Cities, Towards a Green Urban Transition
Authors: Rharbi Noussaiba , İNCEOĞLU Mehmet
Published: December 2022

Morocco is living in a sustainable transition that touches all the fields. The urban transition seems to take a quick turn, especially after 2014, with the establishment of various eco-cities research projects, eco-neighborhoods, and the construction of green cities such as Benguerir, Bouskoura, and Ze-nata. This paper describes some research into sustainability, the parameters behind green urbanism, and the transition effects. It also explains the Moroc-can urbanism transition witnessed after colonization and the sustainability introduction to the country. This research compares two green cities, Benguerir in the south and Zenata on the Atlantic coast. Both cities are constructed by publicly owned and funded companies, providing a common ground for comparison. This paper analyses sustainability parameters target-ed by the study cases.
Limas House Horizontal Proportion and Dulang Module: The Collectivism of Austronesian, Buddhism, Hinduism, Taoism, and Islam in Palembang History
Authors: Aziz Ibnu , Aziz Ahmad Malik Abdul
Published: December 2022

The development of Palembang city is progressing rapidly while traditional limas houses are increasingly rare. As a result, the local context regarding the rules for building limas has become rare and not documented. This is unfortunate considering that limas have architectural and cultural records related to the history of Palembang City, starting from the Austronesian, Hindu-Buddhist, and Taoist to the Islamic period. This study seeks to find the rules of horizontal proportion used in the construction of limas and their relation with the cultural values of society. Researchers explored the dulang,a circular container that holds plates for serving food to eight people, as the base module that builds the floor area of a limas. Data were collected from 50 limas in Palembang City, consisting of 20 four-bengkilas limas (4BL) and 30 three-bengkilas limas (3BL). The results show that 3BL is generally made with four dulang on the front and seven dulang on the side. In comparison, 4BL are built with five dulang on the semi-public side of the bengkilas, three dulang on the back, and seven dulang on the side. Furthermore, the researcher shows that this proportion rule is changed across time in line with the smaller house size. This change signifies the decline of collectivism from a concrete principle to a merely symbolic one. This decline is associated with an increase in the individual's economy and standard of living. This research has implications for efforts to standardize the Palembang limas house model for conserving the city's cultural heritage.
Análisis y Diagnóstico de la Industria Manufacturera Mexicana, Región Centro-norte, Periodo 1993-2018
Authors: Armenta Jimmy Félix , Viramontes-Olivas Oscar Alejandro , Díaz María del Rosario de Fátima Alvídrez , Ceceña María Guadalupe Ibarra , Ávila René Arroyo
Published: December 2022

El proceso de apertura comercial y el tratado comercial de libre comercio con Estados Unidos y Canadá, han propiciado la reestructuración espacial de las actividades manufactureras en las regiones de México. En este ensayo, se evalúa el desempeño de la productividad total para la región centro-norte de México en el periodo 1993-2018. Este trabajo se realizó con la metodología desarrollada por Robert Solow a partir de una función Cobb-Douglas. En general, los resultados muestran a la región con incrementos en empleo y producción superior a la media nacional, lo cual ha propiciado, incrementos significativos en todos los campos de la economía, es decir, mayor dinamismo de las manufacturas en la región, estando relacionado con notables incrementos en la productividad.
YUGOSLAVIA AND DE GAULLE’S REVISION OF THE COLD WAR
Authors: ŽARKOVIĆ PETAR , BEŠLIN MILIVOJ
Published: December 2022

This paper will analyze France’s attempted foreign policy strategy in Yugoslavia and in Eastern Europe during the 1960s, beginning with the various positions of de Gaulle’s France and Tito’s Yugoslavia and the numerous similarities in how the two countries’ diplomacy functioned. In both countries, the course of foreign policy was determined according to the authoritarian characteristics of their systems and of their central figure–the president. Both countries were also interested in transcending the Cold War division of Europe, and they based their strategies on attempts to marginalize the United States and pacify the Soviet regime. De Gaulle’s attempt at a détente, which Yugoslavia was very sympathetic toward and had also committed itself to similar goals, failed due to unrealistic illusions of overcoming this bipolarity by forging a middle way between the two opposing Cold War blocs. Faced with an overestimation of their own influence, along with the Warsaw Pact’s aggression toward Czechoslovakia, Moscow’s complete lack of interest in pacification, and the US’s unwillingness to withdraw, end of de Gaulle’s attempts at détente, in which Yugoslavia would play an important role, came to an end. Nevertheless, similar European and global policy goals brought France and Yugoslavia closer together, and this established the principles on which a cooling down period in the mid-1970s became possible.
THE CHILDHOOD OF MILAN OBRENOVIĆ, THE FIRST KING OF THE SERBIAN RESTORATION: CONTRIBUTIONS TO HIS BIOGRAPHY
Authors: RAJIĆ SUZANA
Published: December 2022

This paper deals with establishing basic biographical information about the Serbian prince and king Milan Obrenović, (1854–1901), which has been very arbitrarily cited in popular and academic publications. The aim is to direct the public to first-rate historical sources that provide information about where he was born, his childhood and education, and the people he encountered before he ascended Serbian throne in 1868. He is an important modern Serbian monarch whose views and actions have become controversial, so it is thus of the utmost importance to ascertain the circumstances surrounding his upbringing and coming-of-age. This is compounded by an ongoing tendency to create myths around his early life based on the content of numerous pamphlets published in the late 19th and early 20th centuries.
Features of the institutional approach to analysis of the pronatalist policy
Authors: Saitova Daria
Published: December 2022

The paper considers the possibility of applying institutional approach to analysis of the pronatalist policy. The pronatalist policy creates space for institutions that should contribute to achievement of its goals, namely, raising the birth rate. However, the consistent application of the institutional approach has shown the absence of institutions with necessary for these goal parameters such as addressee, regulation, object, conditions and sanctions. Institutional impact should be focused on a target group of people and its characteristics. Depending on the groups' age, it should ensure a new parental status for young people aged 20 to 35 or birth of children in a certain order. Given this evidence for focusing on specific recipients and digitizing this process, an examination of their impact upon the effectiveness of pronatalist policy measures seems warranted. Considering the real, rather than conditional generation, we analyses the dynamics of the number of women and the age-specific fertility rates among women aged 20 to 34. It allows assessing the potential for growth in the birth rate in this real generation and predicting the required level of age-specific fertility rates in the next time period. The paper proposes a model for analysis of statistical data, which requires further verification on a larger array. The author also makes an attempt to model a new institution within the pronatalist policy — the institution of potential parents. As possible sanctions for violation of institutional norms by potential parents, it is proposed to use the mechanism of lost profits, that is, a reduction in additional payments and privileges from the state with an increase in the protogenetic interval.
Birth rates of the Buryatian and Russian population of the Buryat Autonomous Soviet Socialist Republic in the 1960s: trends and specifics
Authors: Dashinamzhilov Odon , Lygdenova Victoria
Published: December 2022

The main purpose of the paper is to identify the specifics of demographic modernization on the example of the Russian and Buryatian population in the Buryat Autonomous Soviet Socialistic Republic in the late 1950s-1960s. It is necessary to point that the demographic process among the Buryats started much later than among the Russians, around the end of the 1940s. It followed the Japanese-Mexican model, according to which at the first stage of transition, parallel to decrease of mortality, the rates of birth temporarily increase, as confirmed by statistical data. The transition to the second stage started in the second half of the 1960s. At the same time, the third stage started among the Russian population as in the RSFSR on the whole, although with some delay. The specifics of the demographic development of the peoples under consideration can be found as a result of the analysis of the birth rates that were essentially higher among the Buryats than among the Russians during the period under review. The Buryats had the high level of birth rates due to domination of the traditional life styles, economic activity, social structure, and due to low development of urbanization. The article shows that such a trend of social development was characteristic of all peoples and countries that were at the beginning of demographic transit. Industrialization changed a lot in the traditional way of life and also made impact not only on the economy or culture, but also on the demographic transit. At first, mortality decreased and then birth rates dropped that resulted in lower data for several historical stages. Nevertheless, the new type of reproduction among the peoples of the USSR went in different ways that had an impact on their population dynamics. To sum up, the specifics of demographic development of the peoples under research were reflected in the birth rates of urban and suburban population.
Reproductive strategies of Russian women: results of the pilot survey
Authors: Rusanova Nina , Ozhiganova Anna
Published: December 2022

The sphere of reproduction as an integral part of the health of population today is medicalized at all stages of the formation of reproductive decisions — from conception to childbirth. The choice of reproductive strategies is influenced by two polar trends: the increasing importance of innovative methods of assisted reproductive technologies (ART) and medically-associated reproduction (MAR), on the one hand, and the growing popularity of traditional methods of pregnancy and childbirth management based on folk healing, yoga, oriental medicine and health improving practices, homeopathy, popular psychology and so on., on the other. Thus, two sides of procreative behavior manifest themselves: both the patterns reflecting a biomedical approach based on scientific innovations and the social behavioral models related to public perceptions of health, well-being and gender roles in the society. The article presents the results of a pilot survey of women of reproductive age (n=54) conducted in April 2022 via an electronic questionnaire. The study focused on two topics: ART (awareness and attitude to various ART programs) and pregnancy and childbirth (perception of different forms of preparation for childbirth, the preferred form of childbirth, attitude to medical interventions in the birth process). Data analysis showed that women's reproductive intentions remain medicalized and take into account the possibilities of ART. Also, the results of the survey confirm the growing demand for humanization of maternity care, which is reflected in the desire of women to carefully approach organization of their own childbirth and team of assistants, to attend courses for expectant parents, be more informed and comprehensively prepared.
Consumer behavior of Russians: opportunities and priorities
Authors: Makar Svetlana , Yarasheva Aziza
Published: December 2022

The article examines the dynamics of changes in the volume of monetary income as a means for life of Russians, including implementation of their consumption priorities. It shows distribution of the population's expenditures on consumption of food and non-food products, alcoholic beverages and payment for services. The analysis is based on government statistics on 20 percent income groups, it covers a four-year period, including two years on the eve of the coronavirus pandemic and two years of its development. In the structure of the use of monetary income of the entire (without breakdown into groups) population (2018-2021) are analyzed indicators characterizing changes not only in the purchase of goods and services, but also in the increase/decrease in savings, which act as a reserve for future consumer opportunities. There are identified differences in the change in the share of household spending on food and services in the overall structure of consumer spending by macro-regions of Russia — Federal districts. From the standpoint of macro-regional differentiation in the structure of the use of monetary income for a ten-year period, the emphasis is placed on the purchase of goods and payment for services in Russia as a whole, and especially on the active growth in the Far Eastern and North Caucasus macro-regions. The share of expenses for the purchase of a number of the most important food products in household consumer spending is considered by decile income groups. A comparative analysis of the least and most affluent groups of the population is carried out within the frames of the specified directions reflecting priorities in the consumer behavior of the Russian population.
Indicators of environmental behavior of the population
Authors: Ryumina Elena
Published: December 2022

Ecological behavior of the population in everyday life is considered as one of the main characteristics of human potential. Therefore, were identified indicators separating the use of natural resources and environmental protection in production and in everyday life. The condition for selection of indicators was the possibility of their statistical support. As a result, the indicators of solid household waste generation and household water consumption per capita were selected to formalize the ecological behavior of the population. The issues of waste management, which have recently been raised to the forefront in environmental issues, are mainly studied in technical, technological, organizational, and economic aspects. At the same time, much less attention is paid to the process of formation and volume of household waste among the population. A strong differentiation of solid household waste generation per person by Russian regions is shown. Another indicator of the ecological behavior of the population considered in the article is the volume of water consumption in everyday life per capita. A number of indicators have been found reflecting the volume of water consumption in everyday life, which vary greatly in quantity, since they have different contents and are calculated according to different methods. The choice of the indicator of the use of fresh water for household needs per person is based on the availability of information about it in statistical collections by Russian regions. Multiple discrepancies in the values of this indicator are found out not only in the regions of different Federal districts, but also often in neighboring regions of the same district.
Bending Strength of Apus Bamboo Fiber Reinforced Asphalt Composite Materials as Small Ship
Authors: Susanto Eko , Maheswara Yulian , Widodo Akhmad Basuki
Published: December 2022

Bamboo is generally widely used as a material or construction material in homes. However, the use of bamboo as a raw material for shipbuilding is not yet available. To make bamboo as a material in shipbuilding, the bamboo is assembled or made into a composite to meet class standards as a material for shipbuilding. In this study, the composites used were apus bamboo fiber and asphalt. The method of making the composite uses the hand lay-up method with variations of 1 layer of reinforcement, 3 layers of reinforcement, and 5 layers of reinforcement. The dimensions of the test specimen size refer to ASTM D 790-3 which is then carried out by bending tests to determine the strength of the material due to loading and the elasticity of the material. Furthermore, the results of the bending test will be analyzed using the Anova method and compared with the standard material class in ship construction. Results Asphalt composite material with apus bamboo fiber has the highest bending test value of 27,068 Mpa and the lowest bending test value of 25,998 Mpa. Based on these results, it is stated that the Bamboo reinforced asphalt (BRA) material has not been able to match and even exceed the Bamboo reinforced plastic (BRP) material in the woven, non-woven and random fiber variants. It is influenced by the diameter, and the strength of the shape between the fiber and the matrix.
SURVIVING THE NEW-NORMAL: A STUDY ON PHYSICAL SERVICESCAPE AND VISITOR BEHAVIOR IN QUICK-SERVICE RESTAURANTS IN MALLS IN SURABAYA, INDONESIA
Authors: Anastasia Njo , Gunawan Kevin , Rahardjo Jani
Published: December 2022

Purpose - The “new normal” is the period of adaptation during the pandemic COVID -19 that affects both daily and economic activities, leading to the application of strict health regulations in public places such as shopping malls, tourist sites and gastronomic areas. The appearance of the physical service landscape is adapted to the new normal health regulations. The aim of this study is to firstly investigate the influence of the new regulations with the mediating variable of physical service landscape on QSR visit intention. Second, this study aims to examine the influence of Theory of Planned Behavior (TPB) on QSR visit intention. Design/methodology - This study uses convenience sampling on mall visitors in Surabaya who also visit QSR during the COVID-19 pandemic, starting from July to December 2020. The study sample is 313 visitors which are acquired through questionnaires distributed both online and offline. The data will be analyzed using the technique PLS-SEM 3.0. Findings - Firstly, in the direct path, the results showed that the new-normal regulation significantly influences physical servicescape (exterior design, interior design, and QSR location). Secondly, TPB, which are attitude, subjective norm, and perceived behavioral control, significantly influence QSR visiting intention. In the indirect path, new-normal regulation significantly influences visitors’ intention towards the mediating variable of interior design, while in contrast exterior design and QSR location do not significantly mediate. Originality - This study specifically discusses the changes in the design of the physical service landscape since the implementation of the new-normal regulation caused by the COVID-19 pandemic, which both directly and indirectly influences the behavior of visitors in public areas. Research implication/practical implication - In terms of literature, this study contributes to a deeper understanding of the healthcare service landscape, which interacts with both architecture and marketing, in terms of individual behavior. Furthermore, this study practically helps mall management in deciding the marketing strategy and QSR outlet management to survive in the pandemic by following applicable healthcare protocols.
Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer
Authors: Guillén-Mancina Emilio , Jiménez-Alonso Julio José , Calderón-Montaño José Manuel , Jiménez-González Víctor , Díaz-Ortega Patricia , Burgos-Morón Estefanía , López-Lázaro Miguel
Published: December 2022

Patients with metastatic triple negative breast cancer (TNBC) need new therapies to improve the low survival rates achieved with standard treatments. In this work, we show that the survival of mice with metastatic TNBC can be markedly increased by replacing their normal diet with artificial diets in which the levels of amino acids (AAs) and lipids are strongly manipulated. After observing selective anticancer activity in vitro, we prepared five artificial diets and evaluated their anticancer activity in a challenging model of metastatic TNBC. The model was established by injecting 4T1 murine TNBC cells into the tail vein of immunocompetent BALB/cAnNRj mice. First-line drugs doxorubicin and capecitabine were used as positive controls. AA manipulation led to modest improvements in mice survival when the levels or lipids were normal. Reducing lipid levels to 1% markedly improved the activity of several diets with different AA content. Mice fed the artificial diets as monotherapy lived longer than mice treated with doxorubicin and capecitabine. An artificial diet without 10 non-essential AAs, with reduced levels of essential AAs, and with 1% lipids improved the survival not only of mice with TNBC but also of mice with other types of metastatic cancers.
Estimation of ALU Repetitive Element in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer
Authors: Nair Madhumathy G , Ramesh Rakesh S , M Chandrakala , D Apoorva , VP Snijesh , Ramamurthy Vishakha , Somashekaraiah Vidya M , CE Anupama , Raghunathan Kiruthiga , Panigrahi Anuradha , Das Manjula , Dhar Sujan K. , Prabhu Jyothi S
Published: December 2022

Background: Liquid biopsy is widely recognised as an efficient diagnostic method in oncology for disease detection and monitoring. Though examination of circulating tumor cell (CTC) is mostly implemented for assessment of genomic aberrations, need of complex methodologies for their detection has impeded its acceptance in low resource settings. We evaluated the cell free DNA (cfDNA) as a liquid biopsy tool and investigated its utility in breast cancer patients. Methods: Total cell free DNA was extracted from plasma of breast cancer patients (n=167) with median follow up of more than 5 years, at various stages of the disease. Quantitative PCR was performed to estimate the copy numbers of two fractions of ALU repetitive elements (ALU 115 and ALU 247) and DNA Integrity (DI) was calculated as the ratio of ALU 247/115. Mutations in TP53 and PIK3CA in the cfDNA was estimated by next-gen sequencing (NGS) in a subset of samples. Association of the levels of both the ALU fragments with various clinico-pathological factors and disease-free survival at various stages were examined. Nomogram models were constructed with clinical variables and ALU 247 levels to predict disease-free survival and best performing model was evaluated by decision curve analysis. Results: DI and ALU 247 levels were significantly lower (p<0.0001) in the post-operative plasma when compared to their pre-surgery levels. DI and ALU 247 were found to be significantly higher in patients with metastasis (p<0.05). Patients with higher levels of ALU 247 in their post-operative plasma had significantly poor disease-free survival (p=0.005). Higher level of ALU 247 in circulation also correlated with low tumor-infiltrating lymphocytes (TIL) within their primary tumors in the ER-negative breast cancer subtype (p=0.01). Cox proportional hazard analysis confirmed ALU 247 as an independent variable of disease-free survival both in univariate and multivariate analysis [HR 1.3 (95% CI 1.047 to 1.613, p= 0.017)]. Nomogram model showed addition of ALU 247 with other variables significantly improved (C-index-0.823) the predictive ability of the model. Conclusion: Our results confirm the utility of cfDNA as an evolving liquid biopsy tool for molecular analysis. Evaluation of larger fragment of cfDNA estimated through ALU 247 can provide vital information concurrent with the pathological process of disease evolution in breast cancer and warrants expansion to other cancer types.
Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization
Authors: Adang Estelle A.M.C. , Strous Maud T. A. , van den Bergh Joop , Gach Debbie , Van Kampen Vivian E.M. , van Zeeland Roel E.P. , Barten Dennis G. , van Osch Frits H. M
Published: December 2022

Persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variability (HRV). The aim of this study was to assess the association of HRV upon admission with pulmonary function impairment and number of reported symptoms beyond three months after initial hospitalization for COVID-19 between February and December 2020. Follow-up took place three to five months after discharge and included pulmonary function tests and the assessment of persistent symptoms. HRV analysis was performed on one 10s electrocardiogram obtained upon admission. Analyses were performed using multivariable and multinomial logistic regression models. Among 171 patients who received follow-up, and with an electrocardiogram at admission, decreased diffusion capacity of the lung for carbon monoxide (DLCO) (41%) was most frequently found. After a median of 119 days (IQR 101-141), 81% of the participants reported at least one symptom. HRV was not associated with pulmonary function impairment or persistent symptoms three to five months after hospitalization for COVID-19.
Stigmatizing Monkeypox and COVID-19: A Comparative Framing Study of the Washington Post’s Online News
Authors: Ju Weilun , Sannusi Shahrul Nazmi , Mohamad Emma
Published: December 2022

Abstract: Background: Stigma in health can result in a broad range of vulnerabilities and risk for patients and healthcare providers. The media plays a role in people’s understanding of health and stigma is socially constructed through many communication channels including via media framing. Among health issues that were affected by stigma recently were the Monkeypox and Covid-19. Objectives: This research aims to examine how The Washington Post framed stigma around mon-keypox and COVID-19. Guided by the framing theory and stigma theory, online news coverage for monkeypox and COVID-19 were analyzed to understand the construction of social stigma through the media reporting. Methods: This research employed a qualitative content analysis to compare news framing in The Washington Post online news regarding monkeypox and COVID-19. Results: Based on endemic, reassurance, and sexual transmission frames, the The Washington Post predominantly defined Africa as the source of the disease, blames gay communities, and empha-sizes no need to worry about the spread of the monkeypox virus. For the COVID-19 coverage, The Washington Post described China as the source of the coronavirus and constructs the image of panic towards the spread of the virus. Conclusions: The shifts in stigma discourse essentially manifest racism, xenophobia, and sexism in public health. This research affirms that the media reinforces stigma phenomenon in health through framing and offers constructive suggestions for mitigating this issue.
Shallow and Deep-water Ophiura Species Produce a Panel of Chlorin Compounds with Potent Photodynamic Anticancer Activities
Authors: Klimenko Antonina , Huber Robin , Marcourt Laurence , Tabakaev Dmitry , Koval Alexey , Dautov Salim Sh. , Dautova Tatyana N. , Wolfender Jean-Luc , Thew Rob , Khotimchenko Yuri , Queiroz Emerson Ferreira , Katanaev Vladimir L.
Published: December 2022

A Pacific brittle star Ophiura sarsii has previously been shown to produce a chlorin (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (ETPA) (1) with potent phototoxic activities making it applicable to photodynamic therapy. Using extensive LC-MS metabolite profiling, molecular network analysis and targeted isolation with de novo NMR structure elucidation, we here identify five additional chlorin compounds from O. sarsii and its deep-sea relative O. ooplax: 10S-Hydroxypheophorbide a (2), Pheophorbide a (3), Pyropheophorbide a (4), (3S,4S,21R)-14-Ethyl-9-(hydroxymethyl)-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (5), and (3S,4S,21R)-14-Ethyl-21-hydroxy-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (6). Chlorins 5 and 6 have not been previously reported in natural sources. Interestingly, low amounts of chlorins 1-4 and 6 could also be identified in a distant species, the basket star Gorgonocephalus cf. eucnemis, demonstrating that chlorins are produced by a wide spectrum of marine invertebrates of the class Ophiuroidea. Following purification of these major Ophiura chlorin metabolites, we discovered the high singlet oxygen quantum yield upon their photoinduction and their strong phototoxicity against a panel of cancer cell lines. These studies identify an arsenal of brittle star chlorins as powerful natural photosensitizers with potential photodynamic therapy applications.
The THE ROLE OF AGE AND COMORBIDITIES ON THE OUTCOME OF CONFIRMED CLINICALLY CRITICAL COVID-19 PATIENTS TREATED WITH REMDESIVIR AT INDONESIA'S NATIONAL REFERRAL HOSPITAL
Authors: USMAN Elly , KATAR Yusticia
Published: December 2022

Background: There is currently no viable pharmaceutical therapy for COVID-19 illness that has been validated. The use of remdesivir is one of the medications for which there is no consistent evidence of a significant therapeutic benefit or a meaningful effect on survival. Methods: A retrospective cohort study was used in this study. The subjects in this study were confirmed clinically critical COVID-19 patients who were treated at Dr. M Djamil Hospital Padang, one of Indonesia's national referral hospitals, from January to June 31, 2021. The number of samples in this study was 90 patients. The Chi-square test was performed in bivariate analysis, and the odds ratio was calculated. SPSS version 17.0 was used to analyze the data. Results: The results of this study found that there was an association between ages 50-59 years (OR = 10.23, 95% CI 1.89-55.53), 60-69 years (OR = 4.58, 95% CI 1.25-16.76), and > 70 years (OR = 1.91, 95% CI 1.38 -9.59), comorbid diabetes mellitus (OR = 9.78, 95% CI 1.23-77.66), the number of comorbid > 1 (OR = 10.97, 95% CI 2.19-54.96, and the number of comorbid 1 (OR = 5.69, 95% CI 1.59- 20.41) with the outcome of confirmed clinically critical COVID-19 patients treated with remdesivir. Conclusion: The significance of age and comorbidities on the outcome of COVID-19 patients treated with remdesivir at Indonesia's national referral hospital was confirmed in this study. This study could assist in the management of patient therapy, potentially decreasing morbidity and even patient mortality.
SAFETY AND EFFICACY OF HERBAL REMEDIES: A REVIEW OF THE MODELS FOR VALIDATION OF HERBAL REMEDIES OF SOME NEUROPHARMACOLOGICAL CONDITIONS.
Authors: OLAYIWOLA Gbola
Published: December 2022

Background: Herbal remedies are making waves in many neurological conditions, and it will be wrong to assume that they do not have to be subjected to the same rigorous ethical investigational pathways as for the synthetic medicines/remedies. The primary and most important concern of pharmacologists in the team of drug developers is the safety of the remedy, whether herbal or synthetic. The remedies are aimed at the human body for the alleviation of the medical condition, so it makes sense to protect that body against further injury. In this context, there is no consideration for a different treatment when herbs are involved.
Methods: This review is based on the teaching approaches of the author, with a view to explaining the rationale for some of the experimental steps in neuropharmacological experiments, particularly with herbs. The issues of experimental models are discussed, with sufficient explanations for the choice of the model, the indices to monitor and the interpretation of the indices. Supporting literature are also provided as appropriate.
Conclusions: Appropriate conclusions are drawn and the target audience are put in a good stead of the appreciation of why they do what they do, while correcting what they have not done well.
PROSPECTS OF INTEGRATION OF NANOTECHNOLOGY TO ANTIMALARIAL HERBAL REMEDIES FOR IMPROVED THERAPEUTIC EFFICACY – A CONCISE REVIEW
Authors: ONYEJI Cyprian   .O.
Published: December 2022

Background: The therapeutic utility of herbal medicinal products including antimalarial herbal remedies has been hampered by some unfavorable biopharmaceutical properties of the bioactive constituents such as low aqueous solubility, poor oral bioavailability, poor intestinal permeability and large molecular size. Al these biopharmaceutical issues are responsible for observed reduced in vivo efficacy of some herbal products compared to their in vitro efficacy. These drawbacks can by countered by the integration of nanotechnology. The present article identified the various documented nanosystems and examined the recent efforts in the deployment of nanotechnology in formulations of antimalarial herbal medicines for improved therapeutic efficacies. Also safety considerations in clinical applications of nanoformulations were highlighted.

Methods: The information was acquired from an extensive literature searching of electronic  databases such as  Science-Direct, PubMed, and Google-Scholar to obtain appropriate articles made in the English language which were published up to 2022, using a combination of relevant keywords.

Results:  Only very few herbal antimalarial remedies such as extracts of Azadirachta indica, Momordica charantia, Curcuma longa, and Artemisia species have been nanoformulated and evaluated for antimalarial efficacy.   In all these studies, the drug-loaded nanoformulations exhibited significantly higher in vitro and/or in vivo antimalarial efficacy. The different nanoformulations of antimalarial herbal remedies that have been reported include nanoparticles of lipid-based, cyclodextrin, chitosan/lecithin , liposomes,  nanosuspension,  nanoemulsions, and metal-based nanoparticles..

Conclusion: Different types of nanoformulations of herbal antimalarial drugs have been reportedly prepared by different techniques and these offer advantages of improved efficacies. Safety concerns present a hurdle to clinical applications.
A Review of Abductor Tendon Tears
Authors: Dove James H. , Lemme Nicholas J. , Modest Jacob M. , Talley-Bruns Rachel C. , Tabaddor Ramin R. , Fadale Paul D.
Published: December 2022

» Greater trochanteric pain syndrome consists of a group of associated conditions involving the lateral hip that can be debilitating to patients, mostly women between ages 40 and 60 years.

» Abductor tendon tears are becoming a more recognized cause of lateral hip pain in patients without hip osteoarthritis.

» Diagnosis of this condition is critical to patient care because misdiagnosis often leads to unnecessary prolonged pain and even unnecessary procedures that address different pathologies.

» Treatment strategies consists of nonoperative modalities such as nonsteroidal anti-inflammatory medications, corticosteroid injections, and physical therapy, but for refractory cases, surgical techniques including repair, augmentation, and reconstruction have been well-described in the literature providing patients with acceptable outcomes.
Religion and Employees Fraud Prevention: With Moderation of Spirituality, Leadership and Oganizational Culture
Authors: Abrori Rian , Zulfatillah Auliya , Bullah Habi
Published: December 2022

This study aims to define and analyse the relationship between religiosity and Employees Fraud Prevention with spirituality, leadership dan organizational culture as a moderating variable. The data analysis method used in this research is in the form of multiple linear regression testing and interaction test or moderated regression analysis (MRA). The population in this reseach is Baitul Mal Wattamwil Nuansa Ummah (BMT NU) and Baitul Mal Wattamwil Sidogiri Integrated Joint Venture (BMT UGT Sidogiri) spread across Madura Island. The result indicate that the Religiosity and spirituality Variable affects the employees fraud prevention. This study also verifies that Leadership and Organizational Culture cannot moderate the effect of religiosity on employees fraud prevention.
Manajemen Pengelolaan Taman Wisata Laut Labuhan, Sepulu (Studi Pada Pokdarwis Payung Kuning)
Authors: Arifin Ayu Silviana , Faidal Faidal
Published: December 2022

This study aims to determine the management of Taman Wisata Laut Labuhan, about the work culture, and interpersonal communication that occurs in members of the pokdarwis payung kuning and SMEs. The method used in this research is descriptive with an interpretative qualitative approach, while the data collection techniques used are interviews, observation, and documentation. The data analysis techniques using data reduction, data presentation and drawing conclusions. Then to test the validity of the data using source triangulation, triangulation techniques, and time triangulation.The results of the study indicate that the management of the Taman Wisata Laut has been running in accordance with mutually agreed rules. The Pokdarwis Payung Kuning as the manager has good planning for the development of tourist sites. The work culture of the Pokdarwis payung kuning is by prioritizing togetherness with mutual agreement and enthusiasm and unyielding in carrying out work in accordance with the positions and duties of each member. Coordination that runs smoothly with related institutions and agencies in the management of existing facilities and infrastructure, as well as intense interpersonal communication makes the management of this Taman Wisata Laut become responsive in solving problems that occur in the management of Taman Wisata Laut.
Pengaruh Kualitas Produk, Harga, Dan Promosi Terhadap Keputusan Pembelian Ulang Seblak Duar Bangkalan
Authors: Islamia Nadila , Purnomo Hadi
Published: December 2022

The purpose of this study determines the effectiveness of productquality, price, and promotion of the decision repurchase in Seblak DuarBangkalan. This research usesquantitative methods. The sampling techniqueused non-probability sampling with purposive sampling as a sampling method,this study uses of 100 sample respondents. The population in this study areSeblak Duar Bangkalan customers who have bought. The result of this studyis the product quality and promotion variables that have a partial effect onrepurchase decisions, while the price does not have partially affect ofrepurchase decisions.Keywords: Product Quality, Price, Promotion, Repurchase Decision
Analisis Potensi dan Strategi Pemasaran Destinasi Wisata Pantai The Legend Desa Padelegan Kabupaten Pamekasan
Authors: Safitri Wulan , Andriani Nurita
Published: December 2022

This study aims to describe the potential and discuss the marketing strategy applied at The Legend Beach. This research was conducted at The Legend Beach, Padelegan Village, Pamekasan Regency. The types of data used in this study are primary data and secondary data collected through the process of observation, interviews, and documentation. The analytical tools used are SWOT analysis tools and 7P marketing mix which are then analyzed using Miles and Huberman model analysis techniques. Based on the SWOT analysis, there are several potentials that can be developed at The Legend Beach, including edutourism, mangrove ecotourism, cultural tourism, and the use of The Legend Beach as a promotional tool for the superior products of Padelegan Village. Marketing mix analysis resulted in marketing strategy recommendations, including equipping facilities at The Legend Beach, implementing 5S, providing souvenirs to tourists, setting new rates, improving road access to The Legend Beach, adding road signs, using promotional mix, improving quality and insight of Human Resources, clear division of teams and work, expanding parking areas, arranging uniforms for managers, increasing the number of pine trees around the beach.
DEVELOPMENT OF SCIENCE DIGITAL COMIC ON THE THEME MY AIR POLLUTED TO TRAIN CRITICAL THINKING SKILLS FOR CLASS VII JUNIOR HIGH SCHOOL STUDENTS
Authors: Solehah Nada , Nulhakim Lukman , Nestiadi Adi
Published: December 2022

This study aims to determine the efficiency of science digital comics on the theme of my polluted air to train critical thinking skills of seventh grade junior high school students. The research method used is the research and development (RD) method. By using the 4-D model (Four D Model) proposed by Thiagarajan dkk., (1974) through modifications that are tailored to the needs. The 4-D model is only implemented until the third stage, namely define, design, and development. The instruments used are material expert validation questionnaire sheets, media experts and practitioner experts and student response questionnaire sheets to measure the level of product efficiency. Data analysis is descriptive quantitative and qualitative. The results of this study indicate that the overall validation results of science digital comics on the theme "My Air is Polluted" to train critical thinking skills of seventh grade junior high school students are 92.25%. The results of the efficiency level of IPA digital comic products obtained a value of 82.27% in the "Efficient" category. For further research, it is expected to be able to continue research with a high depth of material and be able to conduct large-scale trials so that research results are maximized.