bluuebunny/crossref_metadata_2025 huggingface dataset:
Incretin Mimetics Restore the ER-Mitochondrial Axis and Switch Cell Fate Towards Survival in LUHMES Dopaminergic-Like Neurons: Implications for Novel Therapeutic Strategies in Parkinson’s Disease
Authors: Panagaki Theodora , Randi Elisa B. , Szabo Csaba , Hölscher Christian
Published: September 2023

Background:

Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder that afflicts more than 10 million people worldwide. Available therapeutic interventions do not stop disease progression. The etiopathogenesis of PD includes unbalanced calcium dynamics and chronic dysfunction of the axis of the endoplasmic reticulum (ER) and mitochondria that all can gradually favor protein aggregation and dopaminergic degeneration.

Objective:

In Lund Human Mesencephalic (LUHMES) dopaminergic-like neurons, we tested novel incretin mimetics under conditions of persistent, calcium-dependent ER stress.

Methods:

We assessed the pharmacological effects of Liraglutide—a glucagon-like peptide-1 (GLP-1) analog—and the dual incretin GLP-1/GIP agonist DA3-CH in the unfolded protein response (UPR), cell bioenergetics, mitochondrial biogenesis, macroautophagy, and intracellular signaling for cell fate in terminally differentiated LUHMES cells. Cells were co-stressed with the sarcoplasmic reticulum calcium ATPase (SERCA) inhibitor, thapsigargin.

Results:

We report that Liraglutide and DA3-CH analogs rescue the arrested oxidative phosphorylation and glycolysis. They mitigate the suppressed mitochondrial biogenesis and hyper-polarization of the mitochondrial membrane, all to re-establish normalcy of mitochondrial function under conditions of chronic ER stress. These effects correlate with a resolution of the UPR and the deficiency of components for autophagosome formation to ultimately halt the excessive synaptic and neuronal death. Notably, the dual incretin displayed a superior anti-apoptotic effect, when compared to Liraglutide.

Conclusions:

The results confirm the protective effects of incretin signaling in ER and mitochondrial stress for neuronal degeneration management and further explain the incretin-derived effects observed in PD patients.
The determinants of wages among disabled Americans in non-STEM and STEM occupations
Authors: López Omar S.
Published: September 2023

BACKGROUND: More than 1 in 4 adult Americans have a disability limiting their daily functioning to earn living wages. Meanwhile, the shortage of U.S. professionals in STEM fields persists because of underrepresentation of specific groups, such as racial and ethnic minorities, women, and people with disabilities. OBJECTIVE: The study investigates the determinants of wages among Americans with disabilities in non-STEM and STEM occupations to explore the feasibility of broadening their participation in STEM careers where they may earn higher wages and thereby, close the wage-gap with their non-disabled peers. METHODS: The study used a research design based on Mincer’s earnings regression model to analyze select variables as wage determinants based on data from the 2018 American Community Survey (ACS). RESULTS: While the findings suggest that within the Americans with disabilities group, working in a STEM occupation with a college degree in a STEM field was the best route to attain maximum wages, significant wage disparities exist compared to Americans without disabilities. CONCLUSION: The implications of the findings for Vocational Rehabilitation providers are discussed.
Morbidity and mortality of newborn from preeclampsia mother with SARS-CoV-2 infection
Authors: Lumbanraja S.N. , Effendi I.H. , Siahaan A. , Bancin B.E.P. , Sinurat T.
Published: September 2023

BACKGROUND: Preeclampsia is a major cause of maternal and infant mortality in Indonesia. Several studies have investigated the association between SARS-CoV-2 infection and adverse maternal, fetal, and neonatal outcomes. The studies found that SARS-CoV-2 infection during pregnancy is associated with an increased risk of maternal morbidity and mortality related to hypertensive disorders, including preeclampsia. However, the studies did not provide specific information on the morbidity and mortality of newborns from mothers diagnosed with preeclampsia with conjunction SARS-CoV-2 infection. METHODS: This hospital-based case-control study was conducted on 28 mother-infant pairs using a systematic sampling method from February 2021 to December 2021. Data were analyzed using SPSS software (version 26), and statistical tests including chi-square analysis, Fisher’s exact test, Mann-Whitney U-test and independent t-test were performed to identify factors associated with study variables in a 95% confidence interval (CI). RESULTS: We conducted a prospective study involving the enrollment of 28 pregnant women with confirmed SARS-CoV-2 infection through RT-PCR tests. Within this cohort, a subset of 4 mothers (14.8%) were diagnosed with preeclampsia. Four preeclamptic patients (100%) experienced fatal outcomes. Furthermore, among the infants born to preeclamptic mothers with SARS-CoV-2 infections, two (50%) newborns not survive. One infant passed away shortly after birth at 30 weeks of gestation, while the other had intrauterine demise at 28 weeks of gestation. CONCLUSIONS: SARS-CoV-2 infection during pregnancy is associated with an increased risk of maternal morbidity and mortality related preeclampsia.
Breastfeeding following bariatric surgery among obese women with and without diabetes mellitus
Authors: Cordero L. , Stenger M.R. , Landon M.B. , Needleman B.J. , Noria S. , Nankervis C.A.
Published: September 2023

BACKGROUND: Information on exclusive breastfeeding (BF) and BF initiation following bariatric surgery (BS) among obese women with diabetes mellitus (DM) and without DM (non-DM) is limited. METHODS: Retrospective cohort study. Obesity was defined by BMI (kg/m2) as grade 1 (30–34.9), grade 2 (35–39.9) or grade 3 (≥40). The 65 women in the DM group (40 women with gestational, 19 with Type 2 and 6 with Type 1) was similar to 84 with non-DM in BS type: Roux-en-Y (51 vs 55%), sleeve gastrectomy (32 vs 35%), laparoscopic gastric banding (17 vs 7%) and gastro-duodenal anastomosis (0 vs 4%). RESULTS: Women with DM were older (35 vs 33y), of advanced age (54 vs 27%), with higher prevalence of grade 3 obesity (66 vs 46%), chronic hypertension (31 vs 10%), delivery of late-preterm infants (23 vs 10%) and neonatal hypoglycemia (25 vs 12%). Although infant feeding intention was similar: BF (66 vs 79%), partial BF (9 vs 7%) or formula (25 vs 14%), at discharge women with DM had lower exclusive BF (29 vs 41%) and BF initiation rates (68 vs 76%) than those with non-DM. Women with grade 3 obesity (52% were DM) differed from those with grades 1-2 (34% were DM) in exclusive BF (27 vs 52%), and BF initiation rates (66 vs 86%). CONCLUSION: After BS, women with DM, especially those with grade 3 obesity, had higher rates of chronic hypertension and preeclampsia and lower rates of exclusive BF and BF initiation than those who had DM but had less severe obesity.
A survey evaluating practice pattern in management of obstetric hemorrhage
Authors: Kaur M. , Phillips J.M. , Ahmadzia H.K.
Published: September 2023

BACKGROUND: Hemorrhage anticipation and management has shifted significantly over the past decade due to evolution of data surrounding management of obstetric hemorrhage. Limited data exists which describe the practical use and clinical application of hemorrhage management. Our goal was to identify obstetric hemorrhage management patterns in a cohort of practicing Maternal Fetal Medicine physicians. METHODS: We administered a survey to Maternal Fetal Medicine (MFM) fellows and faculty that addressed the management of hemorrhage including risk assessment, uterotonic use, antifibrinolytic use, cell saver use, and abnormal placentation management. An email was sent out regarding the survey to a listserv of all Maternal Fetal Medicine fellow program coordinators to disseminate to their faculty and fellows. Eighty responses were obtained. RESULTS: A total of 78 surveys were analyzed. Participants preferred methylergonovine as a first line agent (n = 57; 73%, n = 62; 80%). Most participants would consider using cell salvage when also activating MTP (28, 48%) or during scheduled deliveries who are high risk of hemorrhage (40, 69%). Approximately a third of providers would use TXA (tranexamic acid) prophylactically (n = 21; 28%). Only 26% of MFM fellows felt comfortable performing cesarean hysterectomy without Gynecologic Oncology. CONCLUSION: In comparison to prior reports, TXA use has increased substantially. Further, when looking at the management of abnormal placentation, the use of magnetic resonance imaging and embolization have both increased. Possibly due to the rise in centers of excellence for treatment of accreta spectrum disorders, Maternal Fetal Medicine fellows still feel largely unprepared to perform a cesarean hysterectomy without Gynecologic Oncology.
Predicting risk of peripartum blood transfusion during vaginal and cesarean delivery: A risk prediction model
Authors: Ahmadzia H.K. , Wiener A.A. , Felfeli M. , Berger J.S. , Macri C.J. , Gimovsky A.C. , Luban N.L. , Amdur R.L.
Published: September 2023

OBJECTIVE: The objective of this study is to develop a model that will help predict the risk of blood transfusion using information available prior to delivery. STUDY DESIGN: The study is a secondary analysis of the Consortium on Safe Labor registry. Women who had a delivery from 2002 to 2008 were included. Pre-delivery variables that had significant associations with transfusion were included in a multivariable logistic regression model predicting transfusion. The prediction model was internally validated using randomly selected samples from the same population of women. RESULTS: Of 156,572 deliveries, 5,463 deliveries (3.5%) required transfusion. Women who had deliveries requiring transfusion were more likely to have a number of comorbidities such as preeclampsia (6.3% versus 4.1%, OR 1.21, 95% CI 1.08–1.36), placenta previa (1.8% versus 0.4%, OR 4.11, 95% CI 3.25–5.21) and anemia (10.6% versus 5.4%, OR 1.30, 95% CI 1.21–1.41). Transfusion was least likely to occur in university teaching hospitals compared to community hospitals. The c statistic was 0.71 (95% CI 0.70–0.72) in the derivation sample. The most salient predictors of transfusion included type of hospital, placenta previa, multiple gestations, diabetes mellitus, anemia, asthma, previous births, preeclampsia, type of insurance, age, gestational age, and vertex presentation. The model was well-calibrated and showed strong internal validation. CONCLUSION: The model identified independent risk factors that can help predict the risk of transfusion prior to delivery. If externally validated in another dataset, this model can assist health care professionals counsel patients and prepare facilities/resources to reduce maternal morbidity.
Effects of iron supplementation to iron depleted and iron replete pregnant Danish women: Defining criteria for identification of women who can manage without supplements: A randomized, placebo-controlled study
Authors: Milman N.T.
Published: September 2023

OBJECTIVE: To define criteria based on iron status parameters for the identification of healthy women who do need/do not need iron supplementation during normal pregnancy. METHODS: Randomized, double-blind, placebo-controlled study of 113 women (62 iron-, 51 placebo treated) and their newborns. Iron dose was 66 mg elemental iron as ferrous fumarate daily from 14–18 weeks gestation to delivery. Hemoglobin (Hb), serum (S)-ferritin, S-transferrin saturation percentage, and S-erythropoietin were measured during gestation, prepartum, one week and 8 weeks postpartum. The women were divided in groups according to S-ferritin levels at inclusion:<30,≥30,≥40,≥50 and≥60μg/L. Iron deficiency (ID) was defined as S-ferritin < 15μg/L; iron deficiency anemia (IDA) as S-ferritin < 15μg/L and Hb < 110 g/L. RESULTS: Placebo treated women with S-ferritin levels < 30μg/L at inclusion had a much higher incidence of ID/IDA than placebo treated women with S-ferritin levels≥30,≥40,≥50, and≥60μg/L. S-ferritin levels≥40μg/L were associated with a very low risk of ID/IDA and none of the women with levels≥50 and≥60μg/L displayed ID/IDA. CONCLUSIONS: Women having S-ferritin < 30μg/L in early pregnancy, have a high risk of ID/IDA and should be recommended ferrous iron supplements in appropriate doses. With increasing iron reserves, i.e., increasing S-ferritin, the need for iron supplements diminishes, and placebo treated women having S-ferritin ≥40μg/L seldom develop IDA. Women with S-ferritin levels≥50 and≥60μg/L or higher, have adequate iron reserves and do not need routine iron prophylaxis in pregnancy. The results support the arguments for an individual iron supplementation guided by iron status, to avoid unwanted side effects of unnecessary iron intake.
Accidental lipid overdose in a preterm infant: A case report
Authors: Ryan M.S. , McIntyre J. , Bramwell L & D. , Ojha S.
Published: September 2023

BACKGROUND: Intravenous lipid emulsions (ILEs) provide essential fatty acids during parenteral nutrition (PN). Serious adverse events including death can occur from overdose. We report an accidental overdose in a preterm infant. METHOD: On Day 2 of life, a 29-week gestational age (GA) twin was accidentally given 47.5 mL of Intralipid20% (≈3x daily amount) in 50-minutes. RESULTS: No apparent clinical deterioration occurred, although blood samples were lipaemic. Outcomes at 2 years corrected GA were similar to that of his twin. Service changes were made to infusion packaging and administration to avoid similar errors. CONCLUSIONS: Medication errors in neonates are unfortunately common. Published articles usually focus on poor outcomes, which can increase the distress for parents of children where errors have occurred. Publishing the full spectrum of outcomes instead allows parents and professionals to be aware of all possibilities and lessons learnt, even if serious harm was avoided.
The risk of road traffic crashes for occupational drivers: A responsibility study with comparison to the general population
Authors: Guibert Nicolas , Martin Jean-Louis , Gadegbeku Blandine , Lagarde Emmanuel , Charbotel Barbara
Published: September 2023

BACKGROUND: Road accidents are the leading type of work-related fatalities, but the impact of work-related travel on overall traffic safety has been scarcely studied. OBJECTIVE: The main objective of the present study was to assess drivers’ relative road accident risk between work-related and personal journeys. METHODS: A responsible/non-responsible case-control study was performed on a sample of 7,051 road accidents in France from the VOIESUR project. Logistic regression determined odds-ratios according to work-related versus personal travel, and identified risk factors for responsibility, specific to each of the two sub-groups. RESULTS: Drivers traveling on duty or commuting home were significantly less often responsible for accidents than drivers on personal journeys: OR = 0.75 [0.63; 0.89] and 0.65 [0.53; 0.80] respectively. Responsibility was significantly more frequent in commuting to versus from work: OR = 1.38 [1.06; 1.78]. Among on-duty drivers, professional passenger-transport drivers had the lowest risk of responsibility (OR = 0.25 [0.11; 0.58]), while those on temporary or work/study contracts and professional light goods vehicle drivers had the highest risk (OR = 11.64 [2.15; 62.94] and OR = 29.83 [5.19; 171.38] respectively). When driving under the influence of alcohol, risk of responsibility was higher in commuting home than in personal journeys. CONCLUSION: On-duty drivers showed lower risk of responsibility for an accident than other drivers. However, on-duty drivers on temporary or work/study contracts, who are usually not subject to specific regulations, showed higher risk, and should be the subject of particular attention regarding occupational risk prevention.
The effects of head mounted weight on comfort for helmets and headsets, with a definition of “comfortable wear time”
Authors: Odell Dan , Dorbala Navaneeta
Published: September 2023

BACKGROUND: There are difficult tradeoffs when designing head-mounted equipment such as helmets, lights, cameras, or virtual or augmented reality displays. Increased functionality and battery life adds weight, which in turn reduces comfort. A successful product must balance both comfort and functionality to achieve its product engagement goals. OBJECTIVE: This study defines “comfortable wear time” as a new metric, and applies it to the domain of headsets in determining the relationship between headset weight and comfort. METHODS: Sixteen study participants wore four otherwise identical headsets weighted between 500g–600 g for up to two hours each in an office environment. If participants experienced more than “mild discomfort” (>3 on an NRS-11 discomfort scale), the trial ended early, and the comfortable wear time was recorded. Intensity and location of discomfort was rated at trial conclusion, and qualitative feedback collected. RESULTS: Higher weights were associated with shorter comfortable wear times. Not everyone could wear even the lightest headset (500 g) for the full two hours. Qualitatively, discomfort took many forms beyond the expected neck fatigue or contact pressure and included symptoms commonly associated with motion sickness, such as headache and dizziness. Finally, there were pronounced gender differences with females experiencing more severe discomfort with earlier onset. CONCLUSION: Heavier headsets were less comfortable for the lower quartile of participants –yielding an average of 11 fewer minutes of comfortable wear time per 33 g of weight added. Understanding the discomfort costs from adding weight empowers product teams to find the correct balance to meet their product engagement targets.
Bivariate and Multivariate Data Cloning through Non Linear Regression Models
Authors: Hussain Sajid , Iqbal Zafar , Muhammad Mansoor  , Rashid Ahmed
Published: September 2023

Nonlinear regression analysis holds significant popularity in mathematical, engineering, and social science domains. Disciplines like financial matters, biology, and natural chemistry have broadly utilized nonlinear regression models (NLRMs). Cloned datasets have their own importance in such areas which provide the same fit of bivariate and multivariate nonlinear regression models for the actual datasets. This article presents a sequence of cloned datasets that give exactly the same fit of bivariate and multivariate nonlinear regression models.
Scientific Creativity of P. Sokalskyi: Classic Features and Non-Classical Manifestations
Authors: Hnatyshyn Oksana
Published: September 2023

The purpose of the article is to find the "manifestations of scholarship" in the fundamental work of P. Sokalskyi in the context of the then state of development of scientific knowledge as such, the development of Ukrainian musical science. The research methodology is found in the use of special historical (comparative and historical-typological), epistemological, and generalising methods of analysis. The scientific novelty lies in the fact that for the first time in Ukrainian musicology an attempt was made to analyse the individual scientific achievement of the scientist in the context of the characteristic features of the classical and non-classical periods in the development of science in the last quarter of the nineteenth century. It is substantiated that P. Sokalskyi's research embodies the features of the first period and demonstrates signs of the next — non-classical — stage of its development. At the same time, it has a peculiarly national feature — the focus on the search for the national originality of music, the signs of a national musical style. Conclusions. The analysis of the major study proved that its Author, having materialised the state of Ukrainian musicology in the second half of the nineteenth century, went down in its history as one of the founders of the ideals and norms of scientific thinking, scientific approaches, and objective research methods. It also outlined specific promising areas of further research interests.Key words: history of Ukrainian musicology, classical and non-classical manifestations, individual scientific creativity.
Jagellonian Tradition in Poland and Its Projection in the Structure of the University of Poznan (1922-2023)
Authors: Hysa Oksana
Published: September 2023

The purpose of the article is to analyse the activities of the Department of Musicology of the University of Poznań in the line of the Jagiellonian tradition of Poland in the original refraction of the foundations of European academic musical education from its foundation (1922) to the beginning of the twenty-first century. The research methodology consists in the application of the biographical method (studying the life path of famous representatives of the Poznań school of musicology); the source study method (studying scientific works on the above-mentioned issues); and the musicological and analytical method to study a separate stylistic typology and historiographical achievements. The scientific novelty of the work lies in the identification of the cultural phenomenon of Jagiellonianism in connection with the peculiarities of the foundation and functioning of the Department of Musicology at the University of Poznań. Conclusions. The study helped to trace the path of formation of musicology as a science and academic discipline in Poznań in the line with the Jagiellonian tradition of Poland in the original refraction of the foundations of European academic musical education from its foundation (1922) to the beginning of the twenty-first century. The Department of Musicology headed by L. Kamienski was the only academic unit in Poland where research in the field of ethnomusicology was conducted. This department was the first in the country to launch musicological activities aimed to systematise the collection and process Polish folk music based on live material. A regional phonographic archive was founded at the department. The activities of L. Kamienski and A. Cybinski led to the emergence of a galaxy of Polish musicologists and music historians who were brought up on the principles of the educational and scientific methodology of European academic education. This was a generation of musicologists who received a thorough professional education of the European standard in their homeland.

Key words: Jagiellonian cultural tradition, Institute of Musicology of Adam Mickiewicz University in Poznań, musicological education.
Conductor Dmytro Kotko’s Creative Work in the Mirror of Polish Press (1922–1926)
Authors: Kmetiuk Taras
Published: September 2023

The purpose of the article is to highlight the concert and performance activities of the Ukrainian Naddniprianskyi Choir leaded by conductor Dmytro Kotko based on the materials of the Polish periodicals of 1922–1926. The research methodology consists in the use of methods of analysis and synthesis, systematization of facts, and generalisation of the materials studied. The methodological basis of the work is based on the historical and chronological, source, logical and generalising method to analyse periodical sources, study the work of the Naddnipryanskyi Choir, and identify the impact of its artistic activity on the development of musical life. The scientific novelty of the article is the introduction of new archival documents, a significant database of periodicals of that time, and publications of music criticism for a detailed comprehensive analysis of the choir’s creativity. Conclusions. The scientific article hightlights one of the periods of Dmytro Kotko's artistic activity – the management of the Ukrainian Naddnipryanskyi Choir. The analysis of his work is based on materials from Polish periodicals. Polish press has created a kind of chronicle of the musical life of this ensemble, describing artistry, exemplary stage discipline, professional vocal skills, successful selection of repertoire, original interpretations of choral works, and artistic perfection of performance. A large number of reviews, including those of well-known Polish musicologists, attest to the popularity of the creative institution and its director, Dmytro Kotko. Despite certain contradictions, biased assessments, or contradictory conclusions, the importance of these reviews in periodicals lies, firstly, in the fact that they created a kind of chronicle of the musical life of the Ukrainian Naddnipryanskyi Choir, and secondly, they stimulated the development of historical and theoretical musicology, laid the foundations of musical culture, and preserved valuable documentary facts for posterity.

Key words: Dmytro Kotko, Ukrainian Naddniprianskyi Choir, performance, concert activity, conducting technique, repertoire, national art.
Comparison of platelet rich fibrin and guided tissue regeneration in the treatment of periodontal intrabony defects
Authors:   Division of Odonto-Stomatology, School of Medicine. VNUHCM, Vietnam, Pham Anh Vu Thuy
Published: September 2023

Aim: To compare the outcomes of the treatment of periodontal intrabony defects with platelet-rich fibrin (PRF) combined with open-flap debridement (OFD) and guided tissue regeneration (GTR). Material and method: Thirty individuals with a total of 60 intrabony defects were randomly assigned to one of the 2 treatment groups: group 1 (n=30): OFD combined with PRF and group 2 (n=30): guided tissue regeneration with collagen membrane. Clinical parameters, including the plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), and tooth mobility (TM) were assessed at baseline, 3, 6 and 12 months postsurgery. Radiographic parameters, including bony defect fill (BDF) and alveolar crestal resorption (ACR), were measured at baseline, 6 and 12 months postsurgery and calculated using Sopru imaging 2.38 software. The wound healing index (WHI) was assessed at 7 and 14 days postsurgery. Results : There was a statistically significant improvement in clinical periodontal and radiographic parameters at 6 and 12 months postsurgery in both groups. Between the two groups, the improvement of these parameters was similar, the difference was not statistically significant at 6 and 12 months postsurgery. Both groups had percentages of sites with the wound healing score of 1 between 81% and 100%, but group 1 had a significantly greater number than group 2 at 7 and 14 days postsurgery. Conclusion: latelet-rich fibrin combined with open-flap debridement and guided tissue regeneration with collagen membrane were similarly effective in treatment of periodontal intrabony defects. Using PRF improved better postoperative healing compared to guided tissue regeneration with collagen membrane.
The effect of platelet-rich fibrin in surgical treatment of periodontitis
Authors:   Division of Odonto-Stomatology, School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam, Pham Anh Vu Thuy , Le Hong Ngoc Cam ,   Division of Odonto-Stomatology, School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam
Published: September 2023

Aim: To examine the effect of platelet-rich fibrin (PRF) in surgical treatment of periodontitis. Material and method: Thirty individuals with a total of 60 periodontal intrabony defects were randomly assigned to one of the 2 treatment groups including PRF group: PRF combined with open-flap debridement and control group (n=30): open-flap debridement alone (n=30). The wound healing index was assessed at 7 and 14 days postsurgery. The probing depth, clinical attachment loss, tooth mobility, bony defect fill and alveolar crestal resorption were examined and compared at baseline, 6, and 12 months postsurgery. Results : There was a statistically significant improvement in probing depth, clinical attachment loss, tooth mobility, bony defect fill and alveolar crestal resorption at 6 and 12 months postsurgery in both groups. Between the two groups, the improvement of these parameters was significantly greater in PRF group than those in the control group. The number of healing sites with score 1 in the PRF group was significantly higher compared to the control group at 7 and 14 days postsurgery. Conclusion: Compared to open-flap debridement alone, PRF combined with open-flap debridement results in significantly greater benefits in surgical treatment of periodontitis.
Dental caries status and risk factors among 1–5-year-old children with cleft lip and palate
Authors:   Adora Sai Gon Dental clinic, Bien Hoa, Dong Nai., Nguyen Hien Thi Minh , Ngo Khanh Dong ,   Vietnam Odonto Stomatological Association, Faculty of Public health, University of Medicine and Pharmacy at Ho Chi Minh City., Vu Hoa Anh Dien ,   Department of Dental Public Health, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City.
Published: September 2023

Background: Dental caries is one of the most prevalent oral diseases, and especially more serious in people at risk such as children with cleft lip – palate. Understanding their oral status and the influencing factors will help in preventing tooth decay and improving dental health. Objective: To determine the prevalence of dental caries and risk factors in children from 1 to 5 years old with cleft lip and palate. Method: A cross-sectional study was conducted on 174 children from 1 to 5 years old with cleft lip and palate at the hospitals affiliatated with Odonto-Stomatology faculty, University of Medicine and Pharmacy at Ho Chi Minh City. After a child had been examined for dental caries, his or her father/mother was directly interviewed with a questionnaire to investigate factors affecting the condition of dental caries. Descriptive and inferential statistics were performed using logistic regression. Results: The prevalence of dental caries is 47.1%. The rate of caries in children aged 3-5 years is 3 times higher than that in children aged 1-5 (87.3% and 28.6%, respectively). The percentage of children with caries by geographic region has a statistically significant difference (p <0.05). The highest proportion of dental caries was found in children from the Mekong River Delta (Mekong Delta) (64.2%), the lowest one was those from the South Central Coast (43.5%). The oral hygiene method with gauze after bottle-feeding prevents dental caries 3.3 times better than other methods. Other factors such as cleft form, parents' educational level and socioeconomic status of the family have no effect on children's dental caries. Conclusion: Children from 1 to 5 years old with cleft lip – palate had high prevalence of dental caries. Attention should be paid to bottle feeding time, oral hygiene method and frequency of sugar consumption to prevent dental caries.
Preparation of cough syrup containing dextromethorphan HBr, promethazine HCl and preliminary assessment of formulation stability
Authors:   School of Medicine, Vietnam National University, Ho Chi Minh City, Phạm Toàn Quyền , Đỗ Hoàng Hân ,   School of Medicine, VNU-HCM, Vietnam, Nguyễn Nhân Hậu ,   School of Medicine, VNU-HCM, Vietnam, Lê Minh Trí ,   School of Medicine, VNU-HCM, Vietnam
Published: September 2023

Cough is a popular symptom because of various causes, which lead to several inconveniences in life. Dextromethorphan and promethazine are two active ingredients commonly used in combination in the treatment of coughs with many advantages such as enhanced therapeutic efficiency, limiting drawbacks of each active ingredient, and being easy to use for special patients (children, dyspepsia,…). However, currently on the Vietnamese market, there are no combined preparations of these two substances, these products are only available in foreign countries. This research is done with the goal of the simple, suitable preparation process for a syrup containing dextromethorphan HBr 15 mg and promethazine HCl 6.25 mg in each 5 ml in Viet Nam. Inoculants are evaluated according to the in-house standard criteria and appropriate testing methods included physical properties, pH, density, microbial limit, alcohol concentration, qualitative and quantitative composition medicines. Study on the stability proved the syrup remained stable after 6 months at the storage condition of 40 +/- 2 oC and 75 +/- 5% relative humidity. Formulation and preparation procedure are used to study in larger batch sizes to apply to production.
The investigation of the level of activities of daily living by Katz index and related factors in elderly inpatients at department of cardiology of Thong Nhat hospital
Authors:   School of Medicine, Vietnam National University Ho Chi Minh City, Tran Thai Van , Huynh Dang Kim Khanh ,   School of Medicine, Vietnam National University Ho Chi Minh City, Pham Duyen Vinh Hanh ,   School of Medicine, Vietnam National University Ho Chi Minh City, Nguyen Tien Nhat ,   School of Medicine, Vietnam National University Ho Chi Minh City, Nguyen Trang Ngoc Huong ,   School of Medicine, Vietnam National University Ho Chi Minh City, Ho Dung Si ,   Pham Ngoc Thach Univesity of Medicine, Nguyen Cong Duc ,   Pham Ngoc Thach Univesity of Medicine
Published: September 2023

Background: Assessment of the level of Activities of Daily Living (ADL) in heart failure elderly inpatients is important factors in comprehensive geriatric caring. Objectives: Investigating the level of activities of daily living in elderly inpatients at Department of Cardiology of Thong Nhat Hospital and age, gender and heart failure (HF) by Katz index. Method: A cross-sectional study on 202 elderly inpatients (≥60 years old) treated at Department of Cardiology of Thong Nhat Hospital was assessed ADL by Katz index from 05/2020 to 05/2021. Results: In general population, the proportions of independence, partial dependence, and complete dependence are 64.4%, 16.8%, and 18.8%, respectively. The dependency proportions (complete and partial) in 60-69 group, 70-79 group, ≥80 were 30.2%, 48.1% và 32.3% (p=0.003), correspondingly. Female patients had a higher rate than male patients (45.5% compared to 28.0%) (p=0.035). Patients with HF had a dependency rate of 55.1%, 27.8% higher than the group without HF (p=0.001). Conclusions: The in dependence of ADL rate in elderly inpatients at Department of Cardiology, Thong Nhat Hospital is high. Patients in age group 70-79, female, with heart failure have a higher decline in ADL than the other group.
The control of Low-Density Lipoprotein Cholesterol in the elderly at the clinic of health protective committee for high ranking cadre of Ca Mau province
Authors:   Health Protective Committee for High Ranking Cadre of Ca Mau province, Vietnam, Vuong Tien Huu , Le Teo Van ,   Health Protective Committee for High Ranking Cadre of Ca Mau province, Vietnam, Tran Huy Gia ,   Pham Ngoc Thach Univesity of Medicine, Vietnam, Ho Dung Si ,   Pham Ngoc Thach Univesity of Medicine, Vietnam, Nguyen Cong Duc ,   Pham Ngoc Thach Univesity of Medicine, Vietnam
Published: September 2023

Background: Intensive control of low-density lipoprotein (LDL-C) helps the elderly to prevent primary and secondary cardiovascular events. Objective: Study on the current status of LDL-C control in the elderly at the clinic of Health Protective Committee for High Ranking Cadre of Ca Mau province from November 2020 to January 2021 according to the 2019 European Society of Cardiology and European Atherosclerosis Society guidelines (ESC/EAS 2019). Method: Study included 674 elderly people (≥60 years of age) at the clinic of Health Protective Committee for High Ranking Cadre of Ca Mau province. This was a cross-sectional study, which collected clinical information, medical history and measured the LDL-C serum concentration to classify the cardiovascular risk and the LDL-C control status. Results: This study involved 554 males (82.20%) and 120 females (17.80%). The mean age was 69.28. The age group 60-69 accounted for the highest rate (59.35%). The proportion of the elderly with very high, high, and moderate cardiovascular risk factors according to the ESC/EAS 2019 classification was 34.27%, 44.36% and 21.37%, respectively. There was no one in the low-risk group. The achieving LDL-C target rate was 22.7%. The proportion of achieving LDL-C target in males and females was 21.48% and 28.33% (p=0.104), respectively. In the 60-69 years of age group, the proportion reached the LDL-C target was 23.25%, while the over 69 years old group reached 21.9% (p=0.681). Specific, according to the cardiovascular risk classification, the rate of elderly in the very high-risk group and the high-risk group who achieved LDL-C target was 12.99% and 18.06%, respectively, statistically significantly lower than the moderate-risk group reached 47.92 % (p<0.001). Conclusion: The rate of reaching the LDL-C target following ESC/EAS 2019 guidelines of the elderly at the clinic of Health Protective Committee for High Ranking Cadre of Ca Mau province was relatively low. The rate of the elderly in moderate cardiovascular risk group had a higher percentage of LDL-C target achievement than those in the very high-risk and high-risk groups. There was no statistically significant between reaching LDL-C target with the age and sex.
The treatment outcome of conjunctival resection for conjunctivochalasis: A case report
Authors:   University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam, Nguyễn Đan , Diep Thang Huu ,   Cornea Deparment, Eye Hospital at Ho Chi Minh City, Vietnam, Nguyen Hương Viet Duong ,   University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam; Cornea Deparment, Eye Hospital at Ho Chi Minh City, Vietnam, Lam Vinh Minh ,   Cornea Deparment, Eye Hospital at Ho Chi Minh City, Vietnam, Tran To Ke ,   University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
Published: September 2023

Conjunctivochalasis was defined as loose and nonedematous redundant conjunctiva located between the ocular globe and eyelids, especially at the lower fornix. These redundant conjunctival folds cause a range of symptoms, including grittiness, dryness, epiphora and blurry vision etc. due to the interior nasal punctum blockage and decreased tear film stability. Decreased tear film stability, pooling tears in the eyelid cul-de-sac, tear meniscus disruption, increasing mechanical friction, cause corneal epithelial damage and ocular surface inflammation. Conjunctivochalasis is a common ocular surface disease but well overlooked and often misdiagnosed with dry eye, meibomian gland disease or allergic conjunctivitis. The difficulty in diagnosing conjunctivochalasis is that the symptoms are non-specific, the onset is insidious and many clinicians do not recognize the significance of the conjunctival folds. Surgical treatment is indicated when refractory to medical management (artificial tears, anti-inflammation eyedrops) in order to reconstruct the conjunctival surface and tear menicus function. To better understand the efficacy of surgical management of conjunctivochalasis, we report a case of conjunctival resection before and three months after surgery.
Outcomes of ovarian cystectomy on pregnant patients at Tu Du hospital
Authors:   Department of Gynecology and Obstetrics, School of Medicine, VNU-HCM, Vietnam, Cao Hung Van , Tran Thi Ngoc ,   Tu Du Hospital, Vietnam, Le Thanh Quang ,   Tu Du Hospital, Vietnam, Pham Viet Thanh ,   Me Kong Hospital, Vietnam
Published: September 2023

Objective: This study aimed to evaluate the safety and adverse pregnancy outcomes during and after laparoscopy versus laparotomy for the treatment of ovarian cysts during pregnancy at Tu Du hospital from January 2015 to January 2021. Materials and method: Retrospective cohort study on 309 pregnant women who have ovarian cysts and satisfy the selective criteria at Tu Du hospital from 1/2015 to 1/2021. Result: The total rate of complications in laparotomy was 3.2%; including 0.65% of abdominal wound, 0.65% of internal bleeding, and 1.95% of blood transfusion. No complication in laparoscopy was recorded in the study. The total rate of adverse pregnancy outcomes in laparotomy was 2.60%, which is nearly equally distributed into the threatened miscarriage rate, the miscarriage rate, the rate of premature rupture of membranes in preterm labor, and the stillbirth rate (each rate was approximately 0.65%). Conclusion: There was no adverse event of fetal outcome of laparoscopic operation for ovarian cysts during pregnancy. There was no difference in maternal and fetal complications in both laparotomy and laparoscopy for ovarian cysts during pregnancy.
The first famine in Kazakhstan under Soviet rule: historical and demographic aspects
Authors:   L.N. Gumilyov Eurasian National University, Ustagaliyev Ye. , Aitmagambetov D. ,   L.N. Gumilyov Eurasian National University
Published: September 2023

The article is devoted to the historical and demographic review of the famine in Kazakhstan at the beginning of the twentieth century, known as the "first famine" in the Soviet period. The purpose of this article is to study the works of domestic and foreign scientists from the point of view of historical analysis, to consider approaches to the study of this problem, as well as to assess the causes and consequences of the famine of 1921-1922 from the point of view of modern research. As a research task, the authors of the article identified an attempt to identify the main causes of famine in Kazakhstan, the scale of damage and the impact of hunger on the life of the indigenous population of the country with the help of an overview historical-comparative and historical-demographic analysis. The article discusses new archival materials and the latest research by Russian scientists on the topic under study in recent years. The authors made certain conclusions regarding the fact that not all aspects of the famine of 1921-1922 were sufficiently studied, such as historical, geographical, environmental and migration consequences.
Creation of the solid brain model
Authors:   Saint Petersburg Electrotechnical University, Goncharov V. D. , Evdakova E. G. ,   Saint Petersburg Electrotechnical University, Yashkardin R. V. ,   Saint Petersburg Electrotechnical University
Published: September 2023

The work is devoted to the description of algorithms for the mathematical processing of MRI images of the human brain. The results of mathematical processing are used to create a mathematical model describing the electromagnetic processes occurring in the brain when exposed to transcranial magnetic stimulation. Transcranial magnetic stimulation is used to treat various neurodegenerative diseases. For the development of models, 3D Slicer Simple Data images were selected, which are freely available in DICOM format. For processing and selection of a three-dimensional surface, step-by-step image processing was performed in the 3D Slicer program. As a result of image processing, the interfaces of media with different electromagnetic properties are distinguished, which makes it possible to develop a solid-state model of the brain of a particular person. The solid-state model describes the geometric parameters of the boundary of the brain media with different electromagnetic properties. The recovered surfaces were exported to the ANSYS SpaceClaim finite element analysis environment.
ПРО ПАРАДОКС ВПЛИВУ ОБ'ЄМНОЇ ВИТРАТИ РІДИНИ ЧЕРЕЗ КАВІТАЦІЙНИЙ ГЕНЕРАТОР НА РОЗМАХ КОЛИВАНЬ
Authors: Жулай Юрий Алексеевич
Published: September 2023

In the paper it was established that increase of volumetric fluid discharge through the generator leads to the increase of volume of separated part of the cavity. Collapse of large volume cavity is not accompanied by the oscillatory component of pressure that is a paradox. This paradox is explained from the physical point of view and from standpoint of existing linear mathematical model of the generator. This is due to the fact that at constant ratio of geometrical parameters of the generator the amplitude range of cavitation self-oscillations is defined by velocity of its wall and not by the cavern size.
ДОСЛІДЖЕННЯ ТРІЩИНОСТІЙКОСТІ ДЕТАЛІ ПІД ДІЄЮ ТЕРМОІМПУЛЬСНОГО НАВАНТАЖЕННЯ
Authors: Шипуль Ольга Владимировна , Кузнецов Игорь Борисович , Тевзадзе Григорий Сергеевич , Ходак Роман Александрович
Published: September 2023

The cracking problem of aviation unit part under the influence of the thermal pulse loading were considered. The problem of thermal plasticity during thermal pulse processing were solved in CAE system Ansys; internal stresses were calculated and stress concentration zones in the part were defined. A numerical simulation of crack formation in the zone of greatest stress concentration allowed to determine the stress intensity factors for the case of normal separation, transverse and longitudinal shift and J-integral. This study allows to estimate the defect behavior during thermal pulse part treatment. The reliability of obtained results is confirmed by the adequacy of used models. In subsequently the study of metal fracture toughness allows to improve the method of setting modes for thermal pulse parts treatment taking into account the strength limit.
ХАРАКТЕРИСТИКИ ПОВЗДОВЖНЬОЇ СТІЙКОСТІ БПЛА СХЕМИ «ТАНДЕМ» ПРИ СТАРТІ З ТРАНСПОРТНОГО КОНТЕЙНЕРУ
Authors: Масько Олександр Миколайович
Published: September 2023

The longitudinal stability of the UAV of the container start of the aerodynamic scheme "tandem", at the start from the transport container, is studied. Modeling by the methods of computational aerodynamics shows that such a UAV is unstable at angles of rotation of consoles to 60 ° and stable - at large angles of rotation. In the full-scale experiment it was established that in the range of exit velocities 12 ... 14 m / s, take-off masses of UAV 1.8 ... 3.1 kg, the rate of configuration change during the time 0.2 ... 0.3 s longitudinal stability is ensured during the transition from transport to cruising configuration.
РЕЗУЛЬТАТИ ДОСЛІДЖЕННЯ РОЗПОДІЛУ СТАТИЧНОГО ТИСКУ НА ГОЛОВНІЙ ЧАСТИНІ РАКЕТНОГО АЕРОФІЗИЧНОГО КОМПЛЕКСА ТИПУ М-100 НА ОСНОВІ ЧИСЕЛЬНОГО МЕТОДУ РОЗРАХУНКУ І ЛЬОТНОГО ЕКСПЕРИМЕНТУ ДЛЯ ЧИСЕЛ MАХА ПОЛЬОТУ 1,4М4,2, РЕЙНОЛЬДСА ReL,  ≤108 , ПРИСКОРЕННЯ a ≤32g В УМОВАХ АЕРОДИНАМІЧНОГО НАГРІВУ
Authors: Павлюченко Анатолий Михайлович , Шийко Александр Николаевич , Скорик Андрей Викторович
Published: September 2023

Article is devoted to end-to-end solution of a problem of reliability and reliability of data on distribution of static pressure to surfaces of a head part of a missile M-100 aerophysical system in the range of Reynolds numbers of a flow , Mach numbers , an acceleration  in flight conditions on a flight trajectory in the presence of aerodynamic heating, compressibility of a flow, effect of impact on the boundary layer of the operating engines by overcoming a problem of scale effects on the basis of the numerical solution of the equations of Navier-Stokes within a software product of ANSYS CFX and a flight experiment on a head part of a  M-100 object. The problem of scale effects in aerodynamics of big speeds is discussed, the conclusion is drawn on special value of flight experiments in case of a trance- super- and hypersonic speeds, the review of algebraic, semi-differential and differential models of turbulence is provided and the conclusion is drawn on feasibility of use of model of turbulence of Menter. Calculation of static pressure on a head part of an object M-100 on the basis of the numerical solution of the equations of Navier-Stokes for the turbulent hyperacoustic mode of a flow is carried out. Good coordination of results of numerical calculation of static pressure and flight data. The comparative settlement data on pressure received by authors on the basis of some other methods are provided.
ЗАДАЧА ДІРІХЛЕ ДЛЯ ТРАНСВЕРСАЛЬНО-ІЗОТРОПНОЇ ПАНЕЛІ
Authors: Халилов Сиявуш Ахмедович , Копычко Виктор Владимирович , Кривцов Владимир Станиславович , Минтюк Виталий Борисович , Павленко Виталий Николаевич , Ткаченко Денис Анатольевич
Published: September 2023

This paper is a part of series of previous published papers which are devoted to obtaining analytically-numerical solutions of boundary value problems of the theory of shells and plates with arbitrary stresses and inhomogeneous boundary conditions of the Dirichlet type. Unlike other papers of the series, this paper considers shell from transversely isotropic material. The focus is, as ever, sustainability, convergence and accuracy of obtaining analytically-numerical solutions. A posteriori analysis is performed for cylindrical panel. The numerical results are displayed in detail in numerous charts and tables.