bluuebunny/crossref_metadata_2025 huggingface dataset:
Generic instruments in a synchrotron radiation facility
Authors: Söderström Kristofer Rolf , Åström Fredrik , Hallonsten Olof
Published: May 2022

This paper explores the concept and the levels of genericity of different instruments, or beamlines, at a synchrotron radiation facility. We use conceptual tools from the sociology of science, bibliometrics and data from the European Synchrotron Radiation Facility (ESRF) publication database, enriched by data from Web of Science. The sample size is of 11,218 observations for the period 1996 to 2018. The combined data set includes the beamline name, available from the ESRF library database, which makes the instrument-level analysis possible. We operationalize instrument genericity as the disciplinary diversity in the corpus related to each instrument with a Herfindahl-based index theoretically supported by the concept of generic instruments. As a result, we gain a quantitative insight into the generic character of the instruments, as well as the way in which different scientific fields and the experimental use of instruments group and align.
The effect of academic mobility on research performance: The case of Italy
Authors: Abramo Giovanni , D’Angelo Ciriaco Andrea , Di Costa Flavia
Published: May 2022

This work investigates the effects of researchers’ mobility on their research performance. The reference context is that of national intrasector mobility, in a country, Italy, characterized by a research system lacking the typical elements of an academic labor market. In particular, the analysis was conducted on 568 academics working at national universities and affected by mobility in the period 2009–2014. The effect of mobility on the variation of performance at the turn of the transfer was analyzed considering the interplay of demographic/sociological characteristics of the researchers, as well as contextual factors related to both the organization of origin and destination. Results show that it is the less productive academics who represent the larger share of those who move, and more than half of the mobile academics worsen their performance after the transfer.
Revalidation of the genus Sadala Simon, 1880 with the description of a new genus of Neotropical huntsman spiders (Araneae, Sparassidae)
Authors: RHEIMS CRISTINA A. , JÄGER PETER
Published: May 2022

The genus Sadala Simon, 1880 is revalidated to include the here designated type species, S. keyserlingi Simon, 1880, as well as S. nigristernis Simon, 1880, S. punicea Simon, 1880, S. rufa (Keyserling, 1880) and S. velox Simon, 1880, all comb. rest. The males of S. punicea and S. rufa and four new species are described: S. kaiabi spec. nov. (♂♀), from Brazil, S. nanay spec. nov. (♀) and S. yuyapichis spec. nov. (♂) from Peru, and S. tabatinga spec. nov. (♀) from Brazil and Colombia. The genus Meri gen. nov. is described to include the type species, M. pictitarsis (Simon, 1880), as well as M. mathani (Simon, 1880), M. formosus (Banks, 1929), M. santivincenti (Simon, 1898), and M. trinitatis (Strand, 1916), all comb. nov. transferred here from the genus Olios Walckenaer, 1837. The male of M. trinitatis comb. nov. and twenty new species are described: M. abuna spec. nov. (♂♀), from Ecuador, Brazil and Peru; M. aparia spec. nov. (♀), from Peru, M. arraijan spec. nov. (♀) from Panama and Colombia; M. carabobo spec. nov. (♂♀), M. guri spec. nov. (♂), M. yaciba spec. nov. (♂♀), from Venezuela; M. conduri spec. nov. (♂♀), M. manaos spec. nov. (♂), M. munduruku spec. nov. (♀), M. paiaia spec. nov. (♀), M. quinari spec. nov. (♂), M. rivai spec. nov. (♀), M. tambor spec. nov. (♂), M. tapirapeco spec. nov. (♀), from Brazil; M. jaraua spec. nov. (♂♀), from Venezuela, French Guiana, Surinam, Ecuador, Peru and Brazil; M. kaieteur spec. nov. (♀) from Venezuela and Guyana; M. martinique spec. nov. (♀), from Martinique, Guadelupe and Dominica; M. tumatumari spec. nov. (♀) from Guyana, M. vanini spec. nov. from Brazil and Peru; and M. zeteki spec. nov. (♀) from Panama. Olios orchiticus Mello-Leitão, 1930 is considered a junior synonym of M. trinitatis comb. nov. Both genera and species are described and illustrated. Identification keys and updated distribution maps are provided.
Katydids (Orthoptera: Tettigoniidae) from the Iguaçu National Park, Brazil
Authors: FIANCO MARCOS , SZINWELSKI NEUCIR , FARIA LUIZ R. R.
Published: May 2022

Katydids were surveyed in the Iguaçu National Park (ParNa Iguaçu), the largest preserve of the Interior Atlantic Forest in Brazil. Sampling was carried out in three different areas of the ParNa Iguaçu, including its two predominant phytophysiognomies (Seasonal Semidecidual Forest and Mixed Ombrophilous Forest), and consisted of diurnal and nocturnal active searching for katydids and also using light traps. After collected, specimens were reared until adulthood in order to record their calling songs. Almost a thousand katydids were collected, belonging to 89 species and five subfamilies. Phaneropterinae appeared as the most speciose subfamily (57 species), followed by Conocephalinae (22), Meconematinae and Pseudophyllinae, each one with four species, and Pterochrozinae (two species). Several species were recorded for the first time for the Paraná State, for the South Region of Brazil, and also for the country. Calling songs of 34 species were recorded, 29 of them unknown to science. The description of the sound produced by species of some supraspecific taxa (e.g., Aniarae, Cosmophylla and Scaphurae) is here presented for the first time. Data reinforce the relevance of ParNa Iguaçu for the maintenance of thousands of species from different taxonomic groups and also highlight the catastrophic effects that continuous pressures and threats on the preserve, despite the successive attempts to downgrade this conservation unit, may have on the outstanding biodiversity that is harboured by ParNa Iguaçu.
Diurnal Cycle and Dipolar Pattern of Precipitation over Borneo during an MJO Event: Lee Convergence and Offshore Propagation
Authors: Zhou Yihao , Wang Shuguang , Fang Juan
Published: May 2022

Surface precipitation anomalies over Maritime Continent islands typically lead oceanic precipitation by a week in the form of dipolar pattern before the arrival of Madden–Julian oscillation (MJO) convective phase. The authors study this dipolar pattern over Borneo during the boreal winter MJO event in January–February 2017 using cloud-permitting modeling, observation, and reanalysis datasets. The diurnal cycles of precipitation are analyzed during the local growing and decaying stages of this MJO event. Both the observation and simulation show positive precipitation anomaly over southwestern Borneo and negative anomaly over northeastern Borneo associated with the MJO easterly in the growing stage, whereas the pattern reverses in the decaying stage. Due to relatively high terrain, the low-level flows over Borneo split near the topography on the diurnal time scale. During the late afternoon and night (1700–2000 local solar time), the splitting-flow-induced wake vortices and thermally driven sea breezes tend to converge at the leeside, both contributing to leeward convergence and precipitation, which peaks at midnight. Subsequent offshore propagation during midnight and early morning develops from the leeward inland convection, and propagates northwestwards in the growing stage over west Borneo, and eastward in the decaying stage over east Borneo. Offshore propagation lasts until the next noon when sea breezes and island convection initiate. The timing and location of the offshore propagation suggest that it is not an independent convective mode. Instead, it is tied to the dipolar distribution of island precipitation modulated by the MJO.
ACCESS-C: Australian Convective-Scale NWP with Hourly 4D-Var Data Assimilation
Authors: Rennie Susan , Cooper Shaun , Steinle Peter , Dietachmayer Gary , Krysta Monika , Franklin Charmaine , Bridge Chris , Marshall Matthew , Xiao Yi , Sgarbossa Dean
Published: May 2022

The Australian Bureau of Meteorology recently upgraded its convection-allowing numerical weather prediction system, known as the Australian Community Climate and Earth System Simulator (ACCESS-C). ACCESS-C includes seven domains covering major population centers, nested inside the Bureau’s global NWP system. The upgrade included the introduction of data assimilation, with hourly cycling 4D-Var. With a much newer version of the Unified Model to provide the forecast, a range of storm attribute diagnostics to improve forecasting of severe weather events could be introduced. This paper details the configuration of the new version of ACCESS-C. Some verification compared with its predecessor (a downscaling system of comparable resolution) is presented. Of greater note is an exploration of the differences in the model characteristics between the new and old systems, which will affect how users interpret the outputs.
An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19)
Authors: Alagheband Bahrami Armina , Azargoonjahromi Ali , Sadraei Samin , Aarabi Aryan , Payandeh Zahra , Rajabibazl Masoumeh
Published: May 2022

Designing and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 (COVID-19) pandemic, many large pharmaceutical and biotechnology companies invested a great deal of time and money in trying to control and combat the disease. In this regard, due to the urgent need, many vaccines are now available earlier than scheduled. Based on their manufacturing technology, the vaccines available for COVID-19 (severe acute respiratory syndrome coronavirus 2 (SAR-CoV2)) infection can be classified into four platforms: RNA vaccines, adenovirus vector vaccines, subunit (protein-based) vaccines, and inactivated virus vaccines. Moreover, various drugs have been deemed to negatively affect the progression of the infection via various actions. However, adaptive variants of the SARS-CoV-2 genome can alter the pathogenic potential of the virus and increase the difficulty of both drug and vaccine development. In this review, along with drugs used in COVID-19 treatment, currently authorized COVID-19 vaccines as well as variants of the virus are described and evaluated, considering all platforms.

Graphical abstract
Genomic analysis of two Chinese isolates of hyphantria cunea nucleopolyhedrovirus reveals a novel species of alphabaculovirus that infects hyphantria cunea drury (lepidoptera: arctiidae)
Authors: Peng Xiaowei , Zhang Wenying , Lei Chengfeng , Min Shuifa , Hu Jia , Wang Qinghua , Sun Xiulian
Published: May 2022

Background

Baculoviruses act as effective biological control agents against the invasive pest Hyphantria cunea Drury. In this study, two Chinese Hyphantria cunea nucleopolyhedrovirus (HycuNPV) isolates, HycuNPV-BJ and HycuNPV-HB, were deep sequenced and compared with the Japanese isolate, HycuNPV-N9, to determine whole-genome level diversity and evolutionary history.

Results

The divergence of the phylogenetic tree and the K2P distances based on 38 core-gene concatenated alignment revealed that two Chinese HycuNPV isolates were a novel species of Alphabaculovirus that infected Hyphantria cunea in China. The gene contents indicated significant differences in the HycuNPV genomes between the Chinese and Japanese isolates. The differences included gene deletions, acquisitions and structural transversions, but the main difference was the high number of single nucleotide polymorphisms (SNPs). In total, 10,393 SNPs, corresponding to approximately 8% of the entire HycuNPV-N9 genome sequence, were detected in the aligned reads. By analyzing non-synonymous variants, we found that hotspot mutation-containing genes had mainly unknown functions and most were early expressing genes. We found that the hycu78 gene which had early and late promoter was under positive selection. Biological activity assays revealed that the infectivity of HycuNPV-HB was greater than that of HycuNPV-BJ, and the killing speed of HycuNPV-HB was faster than that of HycuNPV-BJ. A comparison of molecular genetic characteristics indicated that the virulence differences between the two isolates were affected by SNP and structural variants, especially the homologous repeat regions.

Conclusions

The genomes of the two Chinese HycuNPV isolates were characterized, they belonged to a novel species of Alphabaculovirus that infected Hyphantria cunea in China. We inferred that the loss or gain of genetic material in the HycuNPV-HB and HycuNPV-BJ genomes resulted in new important adaptive capabilities to the H. cunea host. These results extend the current understanding of the genetic diversity of HycuNPV and will be useful for improving the applicability of this virus as a biological control agent.
Surgical treatment of acute aortic dissection in a patient with SLE and prior antiphospholipid syndrome on therapy for over 30 years: a case report
Authors: Yamamoto Taira , Endo Daisuke , Shimada Akie , Matsushita Satoshi , Asai Tohru , Amano Atsushi
Published: May 2022

Background

In patients with systemic lupus erythematosus (SLE), lengthy treatment and long-term steroid use are the main risk factors for developing aortic aneurysms or aortic dissections. In patients with cardiac tamponade, hemodynamic collapse may lead to acute renal and hepatic failure.

Case presentation

We report the successful treatment of a 55-year-old woman with SLE since the age of 21. She suddenly felt chest pain approximately 2 weeks before developing fever and vomiting and was admitted to our hospital. Initially, she had severe liver dysfunction and was admitted to the hepatology department, where treatment for fulminant hepatitis was initiated. However, computed tomography (CT) showed an acute aortic dissection (DeBakey type II) and severe bloody pericardial effusion. Therefore, we performed emergency pericardial drainage. Plasma exchange therapy was initiated as emergency aortic surgery was deemed impossible due to impaired liver function tests and coagulation. Ten days later, the patient developed peritonitis due to small bowel perforation, and laparotomy was performed for abscess drainage and perforation closure. She had received steroid pulse therapy at the age of 21. At 40 years of age, she developed deep vein thrombosis due to antiphospholipid antibodies and was prescribed prednisolone. She was ambulatory at 3 months after the onset of acute aortic dissection, and CT revealed a rapidly enlarging true aneurysm in the distal arch. We performed elective aortic surgery. Although there were no antiphospholipid antibodies, surgery could have led to a devastating antiphospholipid syndrome. Therefore, we decided to treat the patient with triple therapy. Methylprednisolone was intravenously administered intraoperatively and at 1 day postoperatively. The patient was discharged without complications after returning to her usual oral prednisolone regimen.

Conclusions

The patient described herein had a systemic circulatory failure due to cardiac tamponade, accompanied by liver failure. This condition is a significant cause of death in patients with aortic dissection-associated SLE and is extremely dangerous. However, multi-specialty intervention helped the patient recover, and she has been attending the outpatient clinic. Aortic surgery requiring hypothermia in SLE patients with antiphospholipid syndrome and a history of thrombocytopenia or thrombosis requires a multi-disciplinary treatment team, including cardiac surgeons and medical experts.
Non-technical skills in pre-hospital care in the Czech Republic: a prospective multicentric observational study (NTS study)
Authors: Peran David , Sykora Roman , Vidunova Jana , Krsova Ivana , Pekara Jaroslav , Renza Metodej , Brizgalova Nikola , Cmorej Patrik Ch.
Published: May 2022

Background

Non-technical skills (NTS) are important for the proper functioning of emergency medical ambulance crews but have hardly been researched in the conditions of clinical pre-hospital care.

The primary objective of this study, therefore, is to describe the use of NTS in practice. The secondary objective is to compare if the performance of NTS varies according to the type of case.

Methods

In this multicentric observational study the modified Team Emergency Assessment Measure (TEAM) score was used to assess the performed NTS of two or more crews on site. The evaluation consisted of leadership, teamwork and task management, rated by a field supervisor.

The study observations took place in real clinical pre-hospital emergency medical cases when two or more crews were dispatched between October 2019 and August 2020. The sample size was determined by researchers prior to the study to at least 100 evaluated events per each of the three participating emergency medical services.

The results are presented as median and interquartile range. The internal reliability, consistency and validity of test items and results were evaluated. The Kruskal–Wallis test and the post hoc Mann-Whitney U test with Bonferroni correction were used for multiple comparisons of three groups.

Results

A total of 359 events were evaluated. Surprisingly, the median value for all eight items was as high as 3.0 with a similar interquartile range of 1.0. There were no differences observed by case type (CPR vs. TRAUMA vs. MEDICAL) except from item 1. A post hoc analysis revealed that this difference is in favour of a higher rated performance of non-technical skills in CPR.

Conclusions

The overall result of the performance of non-technical skills can be regarded as very good and can serve for further evaluations. The crews achieved better parameters of NTS in leadership in resuscitation situations in comparison with general medical events.

Trial Registration

The study is registered at Clinical Trials under the ID: NCT04503369.
Minimizing sample bias due to stigmatized behaviours: the representativeness of participants in a cohort study of alcohol in pregnancy
Authors: Tappin David , Mackay Daniel , Reynolds Lucy , Fitzgerald Niamh
Published: May 2022

Background

Stigmatized behaviours are often underreported, especially in pregnancy, making them challenging to address. The Alcohol and Child Development Study (ACDS) seeks to inform prevention of foetal alcohol harm, linking self-report as well as a maternal blood alcohol biomarker with child developmental outcomes. Samples were requested using passive, generic consent. The success of this approach at minimizing bias is presented comparing characteristics of women who provided samples to those who did not.

Methods

All pregnant women in the study city were sent a Patient Information Sheet (PIS) with their first NHS obstetric appointment letter. The PIS informed them that the NHS would like to take an extra blood sample for research purposes, unless they opted out. Neither the women nor the midwives were informed that the samples might be tested for an alcohol biomarker. This paper examines the extent to which women who provided the extra sample were representative of women where no sample was provided, in terms of routinely collected information: age; body mass index; area-based deprivation; previous pregnancies, abortions and caesarians; smoking status and carbon monoxide level; self-reported alcohol use, gestation and birth weight of their baby. Chi-square and Mann-Whitney U tests were used to compare groups.

Results

3436 (85%) of the 4049 pregnant women who attended their appointment provided the extra sample. Women who did not were significantly younger (p < 0.001), more materially deprived (p < 0.001), and less likely to be considered for intervention based on self-reported alcohol use (p < 0.001). There were no significant differences between the two groups on other routine data.

Conclusions

The use of passive consent without disclosure of the specific research focus resulted in a high level of sample provision. There was no evidence that study blinding was breached, and women who provided a sample were more likely to report alcohol consumption. Passive consent to draw additional blood for research purposes at routine antenatal venipuncture reduced sampling bias compared to asking women to give blood for an alcohol study. This methodology may be useful for other stigmatised behaviours.
Relationship between HER2 overexpression and long-term outcomes of early gastric cancer: a prospective observational study with a 6-year follow-up
Authors: Li Hui , Li Longsong , Zhang Nan , Wang Zixin , Xu Ning , Linghu Enqiang , Chai Ningli
Published: May 2022

Background

Studies have confirmed the prognostic value of the expression status of human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer. However, its role in early gastric cancer (EGC) remains largely unknown. This study explored the association between HER2 overexpression and clinical outcomes of patients with EGC.

Methods

A total of 211 patients who had undergone endoscopic treatment for pN0 EGC were enrolled. The HER2 expression status was assessed using immunohistochemistry (IHC).

Results

The prevalence of HER2 overexpression was 14.2%. HER2 overexpression showed a significant correlation with tumor location (P = 0.033). Multivariate analysis showed that HER2 overexpression was significantly associated with an increased risk of tumor recurrence in pN0 EGC (hazard ratio [HR] = 3.97; 95% confidence interval [CI] 1.30–12.14; P = 0.016) but not overall survival (OS) or disease-specific survival (DSS). Of the included patients, age was associated with OS (HR = 1.11; 95% CI 1.04–1.18; P = 0.002], whereas lymphovascular invasion was significantly associated with poor DSS (HR = 33.66; 95% CI 3.05–371.25; P = 0.004).

Conclusion

This study shows that HER2 overexpression is significantly associated with tumor recurrence in pN0 EGC. Hence, Her2 testing at diagnosis is important and differential treatment and/or follow up strategies for patients with Her2 overexpression may merit future study.
Feasibility of a novel self-collection method for blood samples and its acceptability for future home-based PrEP monitoring
Authors: Cannon Chase A. , Ramchandani Meena S. , Golden Matthew R.
Published: May 2022

Background

Most non-clinic based HIV pre-exposure prophylaxis (PrEP) programs require fingersticks to self-collect blood specimens for laboratory monitoring, a technique that often results in inadequate blood volume for quantitative syphilis and HIV serological testing. We evaluated the acceptability and feasibility of using the Tasso OnDemand™ device as a self-sampling method for PrEP monitoring tests and compared results from samples obtained using the Tasso device to clinician-collected blood samples.

Methods

We enrolled study subjects online and in a sexual health clinic and HIV clinic in Seattle, WA, USA to assess the acceptability of blood self-sampling and preferences for home-based PrEP monitoring. We compared HIV antigen/antibody, quantitative rapid plasma reagin and creatinine results in paired self-collected and clinical specimens collected from a subset of participants.

Results

Of 141 participants, 124 (88%) were interested in collecting samples for PrEP monitoring at home. Among 48 who completed blood collections, 94% found the Tasso device easy to use and 95% felt they could perform self-sampling at home. Of 27 participants who used two devices, 100% collected sufficient blood to perform up to two tests while 33% collected sufficient serum for three tests. Agreement in test results between paired samples was high.

Conclusions

These pilot data suggest that using the Tasso self-collection device is acceptable and could feasibly be used to obtain serum specimens sufficient for guideline-recommended PrEP monitoring, though use of a larger volume device may be preferable.
Memantine for the patients with mild cognitive impairment in Parkinson’s disease: a pharmacological fMRI study
Authors: Kawashima Shoji ,   RCIP-Nagoya Study Group, Shimizu Yoko , Horiba Mitsuya , Ueki Yoshino , Akanabe Ryohei , Kan Hirohito , Kasai Haruaki , Kunitomo Hiroshi , Tanaka Satoshi , Toyota Takenari , Kawashima Shoji , Mizuno Masayuki , Okita Kenji , Matsukawa Noriyuki , Matsukawa Noriyuki
Published: May 2022

Background

Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition. The visuospatial n-back test is useful for assessing both domains. The 0-back test reflects visuospatial recognition, while the 1-back and 2-back tests reflect working memory. Cholinesterase inhibitors are effective in the treatment of PD-MCI and dementia in PD (PDD). Although some studies have reported the efficacy of memantine for PDD, the therapeutic efficacy of memantine in patients with PD-MCI remains uncertain.

Methods

This study aimed to investigate the effects of memantine on brain function in patients with PD-MCI, using a randomized double-blinded crossover protocol and functional MRI (fMRI). Ten patients who completed 16 weeks of follow-up were included. They were randomly assigned to either the memantine or placebo. Patients in the memantine group received 5 mg/day of memantine in the first week. The memantine dose was increased by 5 mg/day per week, until a final dose of 20 mg/day. Patients in the placebo group received the placebo following the same regimen as memantine. After the intervention, they underwent a 4 weeks washout period. Following the crossover protocol, a second intervention was conducted after the washout period. In each intervention, fMRI and neuropsychological tests were performed at the maximum dose period. Comparing the memantine and placebo groups, we investigated difference in the brain regions using the visuospatial n-back test.

Results

There were no significant regions enhanced by memantine comparing with placebo at any load of n-back tests. In contrast, exploring regions reduced by memantine, we found significant reduction of activations within right lingual gyrus and left superior frontal gyrus in comparison between 2-back and 0-back test. A number of correct answers of the 2-back test and time to complete Trail Making Test-A were worse during memantine intervention.

Conclusions

Memantine did not improve visuospatial working memory of the patients with PD-MCI. Treatment for PD should be planned carefully considering the impact on cognitive function. Further study is needed to establish new therapeutic strategy.

Trial registration

UMIN000046104. Retrospectively registered.

First registration date: 28 Sept 2017.
Public acceptability of a technology-mediated stool sample collection platform to inform community-based surveillance of infectious intestinal disease: a pilot study
Authors: Davies Rowan , Iturriza-Gómara Miren , Glennon-Alty Rebecca , Elliot Alex J. , Vivancos Roberto , Alvarez Nishio Anica , Cunliffe Nigel A. , Hungerford Daniel
Published: May 2022

Background

In the UK approximately a quarter of the population experience infectious intestinal disease (IID) each year. However, only 2% present to primary care, preventing a true determination of community burden and pathogen aetiology. The aim of this pilot study was to gauge public acceptability of a technology-mediated platform for reporting episodes of IID and for providing stool samples.

Methods

This study employed a cross-sectional online survey design, targeting individuals 16 + years old within Liverpool City Region, UK. Information sought included demographics, comfortability of reporting illness and IID symptoms, willingness to provide stool, and favoured stool-provision method. Univariable logistic regression was used to examine associations between demographic variables and providing a stool sample. Odds ratios (OR) and associated 95% confidence intervals (CIs) were produced.

Results

A total of 174 eligible participants completed the survey, with 69% female. The sample was skewed towards younger populations, with 2.9% aged 65 + years. Nearly a third (29%) had a household income of less than £30,000 per annum and 70% had attained a degree or higher. The majority identified as White British (81%) and 11% identified as ethnicities typically grouped Black, Asian and minority ethnic (BAME). Three quarters of participants were either ‘Comfortable’ or ‘Very Comfortable’ with reporting illness (75%) and with answering symptom-related questions (79%); 78% reported that they would provide a stool sample. Upon univariable analysis, increasing age – being 55 + (OR 6.28, 95% CI 1.15–117.48), and lower income (OR 2.5, 95% CI 1.02–6.60), was associated with willingness to provide a stool sample. Additionally, respondents identifying as BAME ethnicities and men may be less inclined to provide a stool sample.

Conclusions

This pilot study assessed the acceptability of technology-mediated platforms for reporting IID and provision of stool samples in the community. Respondents were biased towards younger, technologically inclined, more affluent and educated populations. Acceptability for reporting illness and providing a stool sample through technology-mediated platforms was high. While older populations were under-represented, they were more likely to agree to provide a stool sample. Qualitative research is required to better reach older and more deprived populations, and to understand potential age, gender and ethnic differences in compliance with stool sampling.
Online survey of university students’ perception, awareness and adherence to COVID-19 prevention measures
Authors: Akhter Salma , Robbins Meredith , Curtis Perry , Hinshaw Belle , Wells Ellen M.
Published: May 2022

Background

Determining factors correlated with protective measures against COVID-19 is important to improve public health response. This study describes student opinions related to university COVID-19 preventive measures.

Methods

In fall 2020, 643 US university students completed an online survey on perception, awareness, and adherence to COVID-19 preventive measures. Outcomes included protocol effectiveness (self or others), protocol adherence (self or others), consequences of protocol violation, knowledge of violations, and level of concern for COVID-19. Multiple linear regression models determined correlates of outcome variables. Covariates included gender, race, residence, area of study, class, and knowledge of someone with a positive COVID-19 test.

Results

Overall, students agreed with protective measures (equivalent to higher scores). In adjusted linear models, females (versus males) had significantly higher scores for protocol effectiveness (self) (p < 0.001), consequences of protocol violation (p = 0.005), and concern about COVID-19 (p < 0.001). Asian/Pacific Islander (versus white) had significantly higher scores for protocol effectiveness (self) (p < 0.001), consequences of protocol violation (p = 0.008), and concern about COVID-19 (p = 0.001). Graduate students (versus freshman) had higher scores for protocol effectiveness (self) (p < 0.001), protocol adherence (self) (p = 0.004) and concern about COVID-19 (p < 0.001). In contrast, participants who had a positive COVID-19 test had significantly lower scores for protocol effectiveness (self) (p = 0.02), protocol adherence (self) (p = 0.004), and consequences of protocol violation (p = 0.008).

Conclusion

Overall, females, Asian/Pacific Islanders, and graduate students were more likely to agree with or adhere to COVID-19 prevention guidelines but those who tested positive for COVID-19 were less likely to do so. These results may inform future prevention efforts.
Particulate matter in the workplace: effects of a mental models-based folder combined with a practical assignment
Authors: Stege T. A. M. , Bolte J. F. B. , Claassen L. , Timmermans D. R. M.
Published: May 2022

Background

With increasing knowledge on the adverse health effects of certain constituents of PM (particulate matter), such as silica, metals, insoluble ions, and black carbon, PM has been under the attention of work safety experts. Previously, we investigated the perceptions of blue-collar workers in highly exposed areas of work. Subsequently, we developed an instruction folder highlighting the most important aspects of PM risk and mitigation, and tested this folder in a digital experiment. The digital experiment yielded positive results with regards to acquired knowledge about PM, but did not on risk perception or safety behavior.

Methods

In this study, we investigate the effects of the folder when combined with a practical assignment involving a PM exposimeter, showing the amount of particulate matter in microgram per cubic meter in real time on its display for various activities. We tested this at six workplaces of four companies in the roadwork and construction branch.

Results

The results indicate that the folder itself yields an increased knowledge base in employees about PM, but the effects of the practical assignment are more contentious. Nevertheless, there is an indication that using the assignment may lead to a higher threat appraisal among employees for high exposure activities.

Conclusion

We recommend implementing our folder in companies with high PM exposure and focusing further research on appropriate methods of implementation.
Combining education and income into a socioeconomic position score for use in studies of health inequalities
Authors: Lindberg Marie Hella , Chen Gang , Olsen Jan Abel , Abelsen Birgit
Published: May 2022

Background

In studies of social inequalities in health, there is no consensus on the best measure of socioeconomic position (SEP). Moreover, subjective indicators are increasingly used to measure SEP. The aim of this paper was to develop a composite score for SEP based on weighted combinations of education and income in estimating subjective SEP, and examine how this score performs in predicting inequalities in health-related quality of life (HRQoL).

Methods

We used data from a comprehensive health survey from Northern Norway, conducted in 2015/16 (N = 21,083). A composite SEP score was developed using adjacent-category logistic regression of subjective SEP as a function of four education and four household income levels. Weights were derived based on these indicators’ coefficients in explaining variations in respondents’ subjective SEP. The composite SEP score was further applied to predict inequalities in HRQoL, measured by the EQ-5D and a visual analogue scale.

Results

Education seemed to influence SEP the most, while income added weight primarily for the highest income category. The weights demonstrated clear non-linearities, with large jumps from the middle to the higher SEP score levels. Analyses of the composite SEP score indicated a clear social gradient in both HRQoL measures.

Conclusions

We provide new insights into the relative contribution of education and income as sources of SEP, both separately and in combination. Combining education and income into a composite SEP score produces more comprehensive estimates of the social gradient in health. A similar approach can be applied in any cohort study that includes education and income data.
Using threshold analysis to assess the robustness of public health intervention recommendations from network meta-analyses: application to accident prevention in households with children under five
Authors: Wells Molly , Bujkiewicz Sylwia , Hubbard Stephanie J.
Published: May 2022

Background

In the appraisal of clinical interventions, complex evidence synthesis methods, such as network meta-analysis (NMA), are commonly used to investigate the effectiveness of multiple interventions in a single analysis. The results from a NMA can inform clinical guidelines directly or be used as inputs into a decision-analytic model assessing the cost-effectiveness of the interventions. However, there is hesitancy in using complex evidence synthesis methods when evaluating public health interventions. This is due to significant heterogeneity across studies investigating such interventions and concerns about their quality.

Threshold analysis has been developed to help assess and quantify the robustness of recommendations made based on results obtained from NMAs to potential limitations of the data. Developed in the context of clinical guidelines, the method may prove useful also in the context of public health interventions. In this paper, we illustrate the use of the method in public health, investigating the effectiveness of interventions aiming to increase the uptake of accident prevention behaviours in homes with children aged 0–5.

Methods

Two published random effects NMAs were replicated and carried out to assess the effectiveness of several interventions for increasing the uptake of accident prevention behaviours, focusing on the safe storage of other household products and stair gates outcomes. Threshold analysis was then applied to the NMAs to assess the robustness of the intervention recommendations made based on the results from the NMAs.

Results

The results of the NMAs indicated that complex intervention, including Education, Free/low-cost equipment, Fitting equipment and Home safety inspection, was the most effective intervention at promoting accident prevention behaviours for both outcomes. However, the threshold analyses highlighted that the intervention recommendation was robust for the stair gate outcome, but not robust for the safe storage of other household items outcome.

Conclusions

In our case study, threshold analysis allowed us to demonstrate that there was some discrepancy in the intervention recommendation for promoting accident prevention behaviours as the recommendation was robust for one outcome but not the other. Therefore, caution should be taken when considering such interventions in practice for the prevention of poisonings in homes with children aged 0–5. However, there can be some confidence in the use of this intervention in practice to promote the possession of stair gates to prevent falls in homes with children under 5. We have illustrated the potential benefit of threshold analysis in the context of public health and, therefore, encourage the use of the method in practice as a sensitivity analysis for NMA of public health interventions.
Non-participation in a targeted prevention program aimed at lifestyle-related diseases: a questionnaire-based assessment of patient-reported reasons
Authors: Leick Christian , Larsen Lars Bruun , Larrabee Sonderlund Anders , Svensson Nanna Herning , Sondergaard Jens , Thilsing Trine
Published: May 2022

Background

Having an unhealthy lifestyle is associated with a higher risk of developing lifestyle-related diseases. Current evidence suggests that interventions targeting health-risk behaviors can help people improve their lifestyles and prevent lifestyle-related diseases. However, preventive programs are often challenged by low participation rates. Reasons for non-participation include lack of time and/or interest, and/or no perceived need for lifestyle intervention. This study explores causes for non-participation in a sample of people who chose not to take up a targeted preventive program (TOF pilot2 study). Patient-reported reasons as well as sociodemographic characteristics and lifestyle factors are in focus.

Methods

A total of 4633 patients from four Danish GP clinics received an invitation to take part in the TOF pilot2 study. Patients who chose not to participate in the TOF pilot2 study were asked to fill in a questionnaire concerning reasons for non-participation, lifestyle, BMI and self-rated health. Descriptive analyses were used to summarize the results.

Results

A total of 2462 patients (53.1%) chose not to participate in the TOF pilot2 study. Among these, 84 (3.4%) answered the full questionnaire on reasons for not participating, lifestyle, BMI and self-rated health. The most common reasons for non-participation were lack of time, having an already healthy lifestyle, and feeling healthy. Based on their self-reported lifestyle 45 (53.6%) of the non-participants had one or more health-risk behaviors including smoking, unhealthy diet, BMI ≥ 35 and/or sedentary lifestyle and were therefore eligible to receive the targeted intervention at the GP or the MHC in the original TOF pilot2 study.

Conclusion

When planning future preventive programs it is important to know the main reasons for patients to not participate. This study provides rare insight into why people opt out of health interventions and advances the evidence base in this area. Our results may inform efforts to better involve these patients in preventive health programs.

Trial registration

Trial registration number: NCT02797392.
Biomarkers to guide the use of antibiotics for acute exacerbations of COPD (AECOPD): a systematic review and meta-analysis
Authors: Hoult George , Gillespie David , Wilkinson Tom M. A. , Thomas Mike , Francis Nick A.
Published: May 2022

Background

Antibiotics are frequently prescribed for acute exacerbations of COPD (AECOPD) even though most do not have a bacterial aetiology. Biomarkers may help clinicians target antibiotic use by identifying AECOPD caused by bacterial pathogens. We aimed to summarise current evidence on the diagnostic accuracy of biomarkers for detecting bacterial versus non-bacterial AECOPD.

Methods

We searched Embase and Medline using a search strategy including terms for COPD, biomarkers and bacterial infection. Data regarding diagnostic accuracy for each biomarker in predicting bacterial cause of exacerbation were extracted and summarised. We used to QUADAS-2 tool to assess risk of bias.

Results

Of 509 papers identified, 39 papers evaluating 61 biomarkers were eligible for inclusion. Moderate quality evidence was found for associations between serum C-reactive protein (CRP), serum procalcitonin (PCT), sputum interleukin (IL)-8 and sputum tumour necrosis factor alpha (TNF-α), and the presence of bacterial pathogens in the sputum of patients with AECOPD. Having bacterial pathogens was associated with a mean difference (higher) CRP and PCT of 29.44 mg/L and 0.76 ng/mL respectively. There was inconsistent or weak evidence for associations between bacterial AECOPD and higher levels of sputum IL-1β, IL-6, myeloperoxidase (MPO) and neutrophil elastase (NE). We did not find any consistent evidence of diagnostic value for other biomarkers.

Conclusions

There is moderate evidence from heterogeneous studies that serum CRP and PCT are of value in differentiating bacterial from non-bacterial AECOPD, and little evidence for other biomarkers. Further high-quality research on the role of biomarkers in identifying bacterial exacerbations is needed.
Clinically refined epidemiology of nontuberculous mycobacterial pulmonary disease in South Korea: overestimation when relying only on diagnostic codes
Authors: Park Jae Hyeon , Shin Sue , Kim Taek Soo , Park Hyunwoong
Published: May 2022

Background

There have been reports of increases in the incidence and prevalence of nontuberculous mycobacterial pulmonary disease (NTM-PD) in several countries, but no studies have analyzed claims data using laboratory tests. This study aimed to estimate the nationwide epidemiology and medical treatments of NTM-PD according to laboratory tests run in Korea.

Methods

Using claims data from the Health Insurance Review and Assessment Service, we analyzed patients with nontuberculous mycobacterium (ICD-10: A31) who were diagnosed from Jan 2007 to Jun 2019. The incidence and prevalence of NTM-PD and whether related laboratory tests were performed were analyzed. Diagnostic code-based NTM-PD patients were defined as patients who had NTM as a diagnosis on at least 2 occasions within 180 days. Clinically refined NTM-PD patients were defined as those excluding hospital-diagnosed patients with acid-fast bacilli (AFB) culture rates less than 5%. Laboratory tests included AFB smears, AFB culture, NTM identification, and drug susceptibility tests (DSTs).

Results

A total of 60,071 diagnostic code-based NTM-PD patients were evaluated. Clinically refined NTM-PD included 45,321 patients, excluding 14,750 (24.6%) patients diagnosed in hospitals with low AFB culture rates. The annual incidence per 100,000 population increased from 2.9 cases in 2008 to 12.3 cases in 2018. The annual prevalence per 100,000 population increased from 5.3 cases in 2008 to 41.7 cases in 2018. After removing outliers according to the AFB culture rate, a significant decrease in incidence was observed in women younger than 50 years. Among patients with clinically refined NTM-PD, the test rates for AFB culture, NTM identification, and DST were 84.3%, 59.1%, and 40.4%, respectively. From the outpatient clinic, 17,977 (39.7%) patients were prescribed drugs related to NTM treatment, with a median number of prescriptions of 7 (interquartile range (IQR) 3–11) and a median duration from the diagnosis to end of treatment of 330 (IQR 118–578) days.

Conclusions

Although the incidence and prevalence of NTM-PD are on the rise, the recent surge in women 50 years of age is overestimated in patients not adequately tested. In claim-based studies, there may be limitations in estimating the epidemiological data with only the diagnostic codes.
Experiences of recovery and a new care pathway for people with pain after total knee replacement: qualitative research embedded in the STAR trial
Authors: Moore Andrew , Wylde Vikki , Bruce Julie , Howells Nicholas , Bertram Wendy , Eccleston Christopher , Gooberman-Hill Rachael
Published: May 2022

Background

Approximately 20% of people experience chronic postsurgical pain after total knee replacement. The STAR randomised controlled trial (ISCRTN92545361) evaluated the clinical- and cost-effectiveness of a new multifaceted and personalised care pathway, compared with usual care, for people with pain at three months after total knee replacement. We report trial participants’ experiences of postoperative pain and the acceptability of the STAR care pathway, which consisted of an assessment clinic at three months, and up to six follow-up telephone calls over 12 months.

Methods

Semi-structured interviews were conducted with 27 people (10 men, 17 women) between February 2018 and January 2020. Participants were sampled purposively from the care pathway intervention group and interviewed after completion of the final postoperative trial questionnaire at approximately 15 months after knee replacement. Interviews were audio-recorded, transcribed, anonymised and analysed using inductive thematic analysis.

Findings

Many participants were unprepared for the severity and impact of postoperative pain, which they described as extreme and constant and that tested their physical and mental endurance. Participants identified ‘low points’ during their recovery, triggered by stiffening, pain or swelling that caused feelings of anxiety, depression, and pain catastrophising. Participants described the STAR assessment clinic as something that seemed “perfectly normal” suggesting it was seamlessly integrated into NHS care. Even in the context of some ongoing pain, the STAR care pathway had provided a source of support and an opportunity to discuss concerns about their ongoing recovery.

Conclusions

People who have knee replacement may be unprepared for the severity and impact of postoperative pain, and the hard work of recovery afterwards. This highlights the challenges of preparing patients for total knee replacement and suggests that clinical attention is needed if exercise and mobilising is painful beyond the three month postoperative period. The STAR care pathway is acceptable to people with pain after total knee replacement.