bluuebunny/crossref_metadata_2025 huggingface dataset:
Tirta Baruna Symbolization In The Javanese Philosophy Of Leadership Characters: The Leadership Of Sultan Hadiwijaya
Authors: Ediyono Suryo
Published: July 2023

Baruno is one of the most complex leadership philosophies in Hasta Brata that exist today, because Javanese philosophy has several advantages as a concept of leadership. Samudra as a symbol of leadership character with oceanic properties are able to receive water from any river, either dirty or clean water and then process all the water content of the river in the water depth. Baruna are the noble qualities of the universe according to Javanese philosophy, can be a guide for every leader. This research is a case study of character Sultan Hadiwijaya using the historical method, which includes: (1) Heuristic, namely, activity preparing stable-traces of the past (2) Criticism of history, namely investigating whether traces of it true, both form and content (3) Interpretation, namely establishing the interconnected meanings of the facts obtained. Sultan Hadiwijaya is a Pajang leader who have eyes and mind widely. Accepting opinions from around as a sign of a leader's respect for others. Leaders do not swallow the input that comes, but think carefully all the opinions that exist, leaders are able to gain new knowledge from the surrounding. An ideal leader, ie (1) extensive knowledge, (2) good skills, and (3) Attitude or moral praise.
Social expression of the Java community and the relevance education through the film "lemantun" by Wregas Bhanuteja: a study of cultural contextual education
Authors: Khoirunnisa Krismonika , Sumarlam Sumarlam , Lestari Oktavia Winda , Jazeri Mohamad
Published: July 2023

This research is a qualitative-descriptive research. This study also uses two methods, namely descriptive and explanative. Both methods are used to describe and explain the phenomenon of social expression and cultural values of Javanese society in the film “Lemantun”. The phenomenon includes its form, purpose, and context.

Given these paper, the researcher seeks to examine the social expressions and cultural values of the Javanese people through the film "Lemantun" by Wregas Bhanuteja. This study aims to find the relationship between social expression and cultural values that exist in Javanese society. Therefore, the purpose of writing this paper is (1) to find out what forms of social expression and cultural values can be learned from the film "Lemantun", (2) what interpretations are found in social expressions and cultural values.

This study uses the film "Lemantun" as the data source. The data analyzed are utterances or sentences spoken by the players. In this analysis, the researcher attempts to link social expressions and cultural values in the film by associating elements of Javanese culture in Indonesia, considering that the film "Lemantun" is a Javanese-language film entitled "Wardrobe".

The results of this study include the discovery of social expressions and cultural values that exist in Javanese society. This research also seeks to find out how the Javanese people think and the real social etiquette.
Efforts on Developing Sustainable Production of Surakarta’s Tiga Negeri Batik from Handmade Technique to Cold Wax Technique.
Authors: Sulistyati Apika Nurani , Widyastuti Theresia
Published: July 2023

A piece of batik cloth contains philosophical values, symbolic meanings, traces of events, ethnic identity, social stratification, spirituality, and records of the journey of civilization. Tiga Negeri batik is evidence of cultural assimilation and acculturation in Java. Tiga Negeri is the nickname for the three places from which batik is made from the process of designing, drawing (mbatik), and onto coloring. This batik, which is closely related to Chinese culture, originated in Lasem, then during its spread to Surakarta, the motifs and color schemes became richer due to the assimilation between coastal batik and inland batik, and thus it eventually became Tiga Negeri batik from Surakarta. However, recently this unique Surakarta’s Tiga Negeri batik is losing its prestige and requires revitalization efforts to sustain its sustainability.
Baneswa: Innovation of Introductory Media of Javanese Culture for Children Based on Pop-Up Book
Authors: Yulisetiani Septi
Published: July 2023

Javanese culture is very diverse, and local wisdom is important to be preserved. Children are the next generation of the nation who need to know their culture. Implementation of the introduction of culture can be done through learning arts and culture in elementary schools. The introduction of culture to children can be done with certain media that are interesting for children. One of them is in the form of a Pop Up book which is developed according to children's development. This study discusses the development of the Baneswa Pop Up Book which is used as a medium for learning the introduction of Javanese culture through folklore, wayang art, traditional dances, batik diversity, batik writing skills, macapat songs, and Javanese letters. Media development is carried out in several stages, including Analyze, Design, Development, Implementation, and Evaluation. The Baneswa Pop Up Book was developed as a cultural learning medium for children. The design is developed with images that are equipped with an audio-visual QR Code whose use is collaborated with mobile devices. The development of a Pop Up Book that is integrated with technological developments has become an innovation of cultural recognition media. The children gave a good response. They are enthusiastic about learning and getting to know the culture.
THE ECOLOGICAL WISDOM OF BANYUMAS FOLKLOR AS LITERACY MATERIAL FOR CHILDREN
Authors: Yulisetiani Septi , Sutrisno Detria Nur Aini
Published: July 2023

This study aims to describe the ecological wisdom contained in Banyumas folklore. The aim is to find out the forms of ecological wisdom of the Javanese people. The data source for this research is Banyumas folklore in the form of stories. Some of these stories include: Asal Mula Sungai Serayu; Kerajaan Dayeuhluhur Cikal Bakal Kabupaten Cilacap; Sepatnunggal; Lengger Dempet; Asal Usul Dusun Sitinggil. The research method used is qualitative with a literary ecological approach. Data were collected by means of literature study and interview techniques. Data analysis techniques were performed using interactive analysis techniques. Data analysis was carried out by collecting data, reducing data, presenting data, and drawing conclusions. The results of the study show that the various forms of ecological wisdom of the Javanese people in Banyumas folklore. The ecological wisdom of the Javanese people in the story includes wisdom in managing natural resources and wisdom in preserving nature. Natural resources are one of the sources of human life. Natural resources are considered as something important in life. For this reason, humans are given teachings to protect natural resources. Utilization of natural resources must be carried out in a balanced way with activities to preserve nature. Efforts to manage and preserve natural resources are hereditary teachings that are conveyed in the story.

Keywords: Kearifan ekologis; Folklor; Jawa; Banyumas
LOCAL WISDOM IN THE SERAT MENAK LARE AS TEACHING MATERIALS IN SECONDARY SCHOOLS (A STUDY OF LITERATURE ANTHROPOLOGY)
Authors: Rahmawan Arief , Tiyasmala Mipa
Published: July 2023

Local wisdom as part of the cultural values possessed by certain communities is considered as a form of defense of culture against incoming foreign cultures. This study aims to describe (1) the aspects of local wisdom in Serat Menak Lare; (2) the most prominent cultural aspects contained in Serat Menak Lare; (3) the relevance of Serat Menak Lare with Indonesian language learning in senior high school. The research type was descriptive qualitative study with an anthropological literary study approach. The source of data was taken from the book Menak Lare I-IV by R. Ng. Yasadipura I which has been transliterated and translated by Sulistijo HS. The data collection technique used is intensive reading and note-taking. The sampling technique used is purposive sampling which is analyzed by interactive analysis model. The results of the research in the form of local wisdom contained in Serat Menak Lare can be identified in the form of the names of figures, animals, plants, and adjustments to the description of the place setting. The cultural aspects that stand out in Serat Menak Lare are the system of tools and equipment for human life, the arts, and the religious system. Equipment that is often found is palace equipment and war equipment. Local wisdom in the arts is in the form of gamelan musical instruments, dance, and Javanese-style architecture. The religious system found is the nuances of the Islamic religion. Furthermore, Serat Menak Lare is very relevant to be used as an alternative study material of Indonesian language learning in high school/equivalent.

Keywords: local wisdom, Menak Lare, literary anthropology
INITIATING THE JAVANESE METHODOLOGY: DISCOURSE, CHARACTERISTIC, AND PARADIGM
Authors: Widodo Sahid Teguh , Yulisetiani Septi , Suyatno Suyatno
Published: July 2023

Java is a cultural center that is quite influential in the Southeast Asian Region. Since centuries ago, Java has always been the center of attention of products of high cultural knowledge and knowledge. The specific purpose of this research is to develop at an early stage the Java methodology. This research is very strategic to do because the data shows that research on the subject of Javanese culture always shows results that are not optimal. On the other hand, the use of Western methodologies is not able to reach the core Javanese values so that Java only be seen from the outer structure. This study seeks to compile the initial stages of the formulation of the Javanese methodology by collecting data from various Javanese sources, including from the informant, written sources, textbooks, Javanese ancient manuscripts, and various existing traditional ceremonies. The results show that (1) Java has a different conception of truth that has an impact on its methodological implications, (2) the Javanese methodology has a different paradigm, (3) the Javanese methodology is authentic in the attitudes, behavior, and ways of the Javanese people in carrying out their cultural life.

Keywords: Methodology; Java; research; culture.
The Relationship Between Gender and Communication Apprehension among Administrative Staff in Universiti Utara Malaysia
Authors: Diah Muhammad Fadhli Mohd , Rahman Nadia Abd , Hussain Salmi , Zahir Nasyrul Hakim Mohd , Abdullah Juwati
Published: July 2023

ABSTRACT

This research addresses issues on communication apprehension in using English language among administrative staff (grade 19) at Universiti Utara Malaysia (UUM). The notion of communication apprehension in this context is their anxiety in executing language tasks in terms of: group discussion, meeting, interpersonal and public speaking by using English language as medium. The objectives of this research are to identify the level of anxiety in using English language among the administrative staff and to find the correlation of communication apprehension with academic background and also gender. The methodology used in this research is using a quantitative approach and applying an instrument called Personal Report of Communication Apprehension (PRCA-24) developed by James C. McCroskey (1982) in order to assess the level of anxiety in using English language. The findings revealed that have female experience lower CA than the male participants.

Keywords: Communication Apprehension, English, PRCA-24, Administrative Staff, Gender
The Transition Of Women's Ideology In Modern Javanese Literature
Authors: Nugroho Yusro Edy
Published: July 2023

Abstract
This study aims to analyze the struggle for women's idealism in modern Javanese literature. The approach used is ideological hegemony and content analysis methods to classify and analyze data from one classical Javanese literary work and two modern Javanese literary works, namely "Serat Wulang Putri" by Nyai Adisara, Novel "Larasati Modern" by Sri, "Katresnan" by Soeratman Sastradihardja, and "Nona Sekretaris" by Suparto Brata. The results of the study show that the development of women's idealistic thinking begins with an inner strength that is patient and accepts the rights of the husband, to become equal friends with men. In the classical period, a restriction only focused on the domestic realm. Even though the reality of the domestic realm still existed in later times, those who had education, independence, and personal wisdom became part of the renewal process. As for the older generation, there is friction over traditional customs in society. What used to be a fixed standard of action has been adapted by itself along with educational developments and foreign cultural influences.

Keywords: Ideology, hegemony, women, Javanese Culture, Modern Javanese Literature.
Development of digital learning evaluation In realizing Suistainable Development Goals (SDGs)
Authors: Aji Sudi Dul , Pratiwi Hestiningtyas Yuli , Hakim Arief Rahman , Hudha Muhammad Nur , Azka Nada Damai
Published: July 2023

This research is motivated by one of the goals of the SDGs, namely realizing quality learning and handling environmental change. The purpose of this study is to determine the feasibility and practicality of evaluating digital learning in realizing the SDGs for elementary school students. This research is a development research with the ADDIE model (Analysis, design, development, implementation and evaluation). The test subjects in this study were class VI students at SDN 02 Putatkidul Gondanglegi. The data collection instrument uses a questionnaire. Data analysis techniques use quantitative data. Digital Study Evaluation created using the Kahoot! based on the results of the material validation, a score of 93.75% was obtained in the very feasible category, the results of the language validation were 95% (very feasible), the results of the teacher's practicality validation were 88.8% (very practical) , the students' practicality results were 94% (very practical)
Competency of innovative thinking of case study teachers at SMPN 10 Singkawang
Authors: Noni Noni , Astuti Indri , Afandi Afandi
Published: July 2023

The educational process carried out must run optimally, therefore the teacher has an important role in developing and designing a lesson in order to provide a maximum learning experience for students. Innovative teacher competencies must be owned by today's teachers. This study aims to see and assess the competence of innovative teachers at SMPN 10 Singkawang. The sample in this study was 15 teachers who taught at SMPN 10 Singkawang by filling out an innovative teacher competency questionnaire. The questionnaire consists of 4 indicators, namely observing, asking questions, networking ideas, and experimenting. Innovative competency assessments are very helpful in providing an overview of the qualities possessed by teachers so that improvements can be made for the better. The quality of teachers at SMPN 10 Singkawang is clearly reflected in the results of the study, teachers at SMPN 10 Singkawang have innovative teacher competencies with good criteria. (Average: 73.03).
Policy analysis of independent curriculum in elementary schools
Authors: Yulianti Yulianti , Hadi Syamsul
Published: July 2023

The purpose of this study is to analyze the policy of implementing the independent curriculum at the elementary school level. This type of research is qualitative with a literature study approach, using a descriptive method in presenting data collection from the keywords Independent Curriculum and Elementary School which was carried out in various online journal sources through Google Scholar. The results of the selection using 50 articles from national journals related to the independent curriculum in elementary school’s state that the essence of the Independent Curriculum is to set goals to provide space for each individual to grow and develop according to their unique nature, the implementation uses a differentiation approach to facilitate students so that their learning needs are met. Implementation of the Independent Curriculum according to the level of school or madrasah readiness through the willingness of the principal and teachers is the key to success.
Implementation of the STEAM model in mathematics subjects to improve learning outcomes
Authors: Rozhana Kardiana Metha , Atmaja Adi Tri , Irianti Nathasa Pramudita , Sari Nila Kartika , Avalentina Kardiana Zendha
Published: July 2023

The purpose of this research is to implement the STEAM learning model to improve the mathematics learning outcomes of fourth grade elementary school students. The method used is classroom action research with research procedures including implementation, among others, preparing action plans, implementing actions, observing, and reflecting. The results obtained in cycle 1 of the student's average score were only 58.5 with an incomplete scale and the need for improvement/reflection. After the action in cycle 1, cycle 2 found a significant increase in learning completeness, namely reaching 85.75. So it can be concluded that the STEAM learning model can be implemented in class IV in mathematics.
Differentiated learning through the PBL model to improve indonesian language learning outcomes for elementary school students
Authors: Solehudin Solehudin , Rochmiyati Siti
Published: July 2023

One of the reasons for the low achievement of learning Indonesian in SDN 2 Tlogosari is the lack of attractiveness of students during learning. This study aims to determine the increase in student learning outcomes in the main idea material through differentiated learning with the Problem Based Learning (PBL) model. This type of research is classroom action research (CAR). The research subjects were grade 4 students at SDN 2 Tlogosari, Ayah District, Kebumen Regency. Data collection techniques using the methods of observation, interviews, and tests. The data obtained is then analyzed. The results of the research show that the implementation of differentiated learning in the PBL model can improve student learning outcomes in the main idea material.
MHJournal en la senda de la ruta diamante de las revistas de ciencias sociales y artes visuales. Editorial
Authors: Jurado Martín Montserrat
Published: July 2023

Después de varios años trabajando el modelo de edición de la ruta diamante sentimos que la confianza de la comunidad científica en este sistema empieza a dar sus frutos. Como resultado hemos experimentado mayor interés por ella, incremento del número de recepción de textos, de interés por coordinar monográficos, de menciones a los textos publicados, incluso nos invitan a ofrecer charlas nacionales e internacionales sobre la gestión que realizamos, etc. Como reflejo de lo descrito publicamos el número 14 de 2023 con un total de 30 textos.
Technology Focus: EOR Operations (June 2023)
Authors: Mukherjee Soujatya
Published: July 2023

While supply disruptions and price volatility are not new to the oil and gas industry, the dramatic drop in oil prices because of the COVID-19 pandemic severely affected global enhanced oil recovery (EOR) projects. To add fuel to the fire, the current geopolitical scenario leading to a surge in commodity prices and supply chain disruptions exacerbated this situation by negating any chances of recovery, at least in the short term.

Concurrently, the rise in energy consumption and increasing demand for energy security worldwide warrants the need to increase global hydrocarbon production. However, rising environmental concerns with regard to greenhouse gas emissions, coupled with a decrease in the availability of easy-to-produce hydrocarbon resources, mandate the need for a gradual shift toward optimized recovery strategy in a sustainable and cost-efficient manner. As a result, current circumstances dictate focusing on low-cost and low-carbon EOR barrels to secure energy supply in the shorter term while continuing to develop innovative technologies and strategies for enhancing production in the longer term.

Energy consumption for mature waterfloods increases sharply at higher water cuts primarily because of the recirculation of water through the existing swept pathways. Lower volumetric sweep in reservoirs leads to excessive water production and less oil recovery. To curb the menace of excess water production, conventional EOR techniques such as polymerflooding or in-depth conformance-control techniques are mostly implemented.

Both methods have demonstrated cost savings because of reduced watercuts and reductions in CO2 generation by lowering reinjection of produced water. Additional costs of injectants, transport, and topside facilities, however, contribute to higher project costs. Early optimization measures for existing waterfloods using machine-learning (ML) approaches could enable optimal reservoir management and production by delineating reservoir heterogeneities more efficiently and predicting more-effective interwell connectivity. Furthermore, ML could contribute directly to the optimization and surveillance of EOR applications, which would subsequently affect the performance and the cost of such projects, thereby supporting the achievement of low-cost and low-carbon EOR barrels.

Recommended additional reading at OnePetro: www.onepetro.org.

SPE 214268 A Novel Approach To Combine Models To Evaluate Interwell Connectivity in a Waterflooded Reservoir With Limited Injection History by Yanfidra Djanuar, Dragon Oil, et al.

SPE 210657 A Laboratory-to-Field Approach and Evaluation of Low-Salinity Waterflooding Process for High-Temperature/High-Pressure Carbonate Reservoirs by Hemanta Kumar Sarma, University of Calgary, et al.

IPTC 22733 Like Cures Like Microbial Enhanced Oil Recovery in Biodegraded Crude by Thanapong Ketmalee, PTTEP, et al.
"An Energy-Efficient Algorithm for Resource Allocation in H-CRAN((EE H-CRAM)) for 5G Networks"
Authors: SAHU RANI , Sahu Vinay
Published: July 2023

The demand for faster internet has increased rapidly in today's generation due to more people using it. To keep up with this growth, a new network called 5G is being developed to replace the current 4G network. 5G has been designed to meet all the communication needs of users. One promising technology for this new network is Heterogeneous Cloud Radio Access Network (H-CRAN), which is energy-efficient and can handle high data rates. By using this network, better service quality can be achieved by turning small cells into bigger ones. This network is different from the usual networks we have today, because it uses a type of radio system that is much better at reusing radio resources. The structure of this network includes more Remote Radio Heads mounted around the Macro Base Station. This type of network is very helpful in saving energy and achieving high Energy Efficiency compared to regular networks. Its resource allocation techniques can optimize the limited spectrum resources by reducing the interference between users. Traditional cellular networks have not been able to save energy effectively, but this network is seen as a promising solution to the challenges faced by 5G networks, such as high data rates, limited power, and delays. In our paper, we suggest some ways to make H-CRAN more energy-efficient. We propose energy-efficient methods for H-CRAN (EE H-CRAM), incorporating an energy-efficient resource allocation management design that caters to the heterogeneous cloud radio access networks in 5G. We use a special energy-saving program to manage the resources of the network, which is designed for 5G. By using this program, we can improve the speed of the network. Overall, our paper proposes an innovative and energy-efficient approach to H-CRAN design, which can significantly improve the performance of the 5G network.
A Clinical Comparative Study between Foldable Capsular Buckle Pressing and Conventional Scleral Buckling in the Treatment of Rhegmatogenous Retinal Detachment
Authors: Zhang Baike , Li Cheng , Zhang Ning , Jia Yong , Guo Lisha , Xing Yaofan , Zhang Xiangyang , Lu Cong , Liao Sha , Tian Xuemin
Published: July 2023

Background
To compare the clinical efficacy of scleral buckling using Foldable Capsular Buckle (FCB) and conventional Scleral Buckling (SB) for the treatment of rhegmatogenous retinal detachment (RRD).
Methods
Analysis of 32 patients with 32 eyes with RRD treated with FCB and 28 patients with 29 eyes with RRD treated with conventional SB. Pre-operative and Post-operative examinations were recorded. The surgical success rate, best corrected visual acuity (BCVA), intraocular pressure (IOP), and persistent subretinal fluid (SRF) were compared.
Results
All the RRD were successfully reattached in both groups at 12 weeks postoperatively. At 12 weeks postoperatively, the BCVA improved from 1.29 ± 0.75 (LogMar) to 0.36 ± 0.25 (LogMar) (P ≤ 0.05) of the FCB group and 1.15 ± 0.69 (LogMar) to 0.33 ± 0.22 (LogMar), P < 0.000 of SB group. IOP improved in both groups, from 12.59 ± 2.83 mmHg to 15.45 ± 3.56 mmHg, P < 0.05. in FCB group and from 12.9 ± 2.68 mmHg to 15.03 ± 3.18 mmHg, P = 0.007 in SB group. In the SB group, 9 eyes showed persistent SRF postoperatively, while in the FCB group, 1 eye exhibited persistent SRF. In FCB group, the average operation time was 45.26 ± 11.24 minutes, and in SB Group, the average operation time was 97.45 ± 21.38 minutes, P < 0.0001.
Conclusions
Both surgeries can effectively reattach the retina and improve patients' BCVA, IOP, but the FCB external compression group has shorter surgical time, controllable complications, and high safety without pulling the extraocular muscles and the risk of oculocardiac reflex.
Trial registration:
The prospective observational clinical study protocol was approved by the Institutional Review Board and Ethics Committee and registered of clinical research center in the 988th Hospital of People’s Liberation Army Joint Logistic Force, China (9882019000), and registered in the the 988th Hospital of People’s Liberation Army Joint Logistic Force Clinical Research Center (LHGU20190867, 03/07/2019). The registration date was from 2019 to 2023.
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Authors: Erkers Tom , Struyf Nona , Arnroth Cornelia , Vesterlund Mattias , James Tojo , Sunandar Stephanie , Bohlin Anna , Hamberg-Levedahl Kerstin , Bengtzén Sofia , Jafari Rozbeh , Orre Lukas , Lehtiö Janne , Lehmann Sören , Ostling Paivi , Kallioniemi Olli , Seashore-Ludlow Brinton
Published: July 2023

Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the impact of sample handling on high-throughput functional drug testing, mass spectrometry-based proteomics, and flow cytometry. Our study highlights conditions where standardization is needed to improve reproducibility, and where validation of data generated from biobanked cohorts may be particularly important.
Action research to foster knowledge and understanding of medical and health sciences students about patient safety in a climate of interprofessional education
Authors: Guraya Salman Yousuf , Sulaiman Nabil , Hasswan Ahmed , Salmanpour Vida Abdolhamid , Jirjees Feras Jassim , Taha Mohamed Hassan , Mahmoud Ibrahim Eltayeb , Alamara Jennat , Kawas Sausan AL , Awad Manal , Dias Jacqueline Maria , David Leena R , Haider Mohamed Aly , Salman Shaista , Dash Nihar Ranjan , Al-Qallaf Amal , Shorbagi Sara
Published: July 2023

Background
Interprofessional education (IPE) plays an elementary role in improving healthcare outcomes by shared understanding and by reducing errors and adverse events. Unfortunately, most medical and health professionals have not received training for patient safety in an interprofessional setting, which can meet the needs of healthcare systems. This study aimed to evaluate the effectiveness of an IPE-based workshop in fostering the knowledge and understanding of senior medical and health sciences students about patient safety at the University of Sharjah in UAE.
Methods
Using a random sampling technique, we recruited students from College of Medicine (CoM), College of Pharmacy (CoP), College of Dental Medicine (CDM), and College of Health Sciences (CHS). The online synchronous real-time workshop included interactive resource sessions, breakout room discussions using real clinical cases, and pre-post surveys using a questionnaire with three domains of patient safety; medical professionalism, leadership in healthcare, and precision medicine.
Results
A total of 248 students and 20 facilitators participated in the workshop. CoM had the highest representation (47.5%), followed by CoP (36.5%), CHS (13.3%), and CDM (2.7%). There was statistically improved understanding in all domains of patient safety across all colleges (p < 0.001). Notably, students in years four and five from CoM and CoP showed significant improvement in their perceptions than other colleges (p < 0.001). The participants encountered challenges of weak internet connections, software issues, technical failures, and power outages during the workshop
Conclusion
This study highlights a positive impact of the IPE-based interventional workshop on the students' knowledge of patient safety. This underscores the paramount role of IPE in improving perceptions and approaches towards patient safety in the context of healthcare education.
Enhancement of crystallization and adjustment properties for biocompatible poly(lactide)-based thermoplastic polyurethane via stereocomplexation
Authors: Jing Zhanxin , Huang Xiaolan , Liang Jialing , Xu Chenyue , Li Yong
Published: July 2023

A novel biocompatible PLA-based thermoplastic polyurethane based on poly(lactide)-b-poly(hexylene succinate)-b-poly(lactide) triblock copolymers was synthesized via polycondensation, ring-opening polymerization and chain extension reactions. The chemical structure and molecular weight of the synthesized PLA-based thermoplastic polyurethane were characterized by FT-IR, 1H NMR and GPC, and the results revealed that the synthesized polyurethane with multi-block structure exhibited a larger molecular weight with respect to the corresponding triblock precursor. XRD and DSC results indicated that thermoplastic polyurethane exhibited poor crystallization ability, which may be attributed to the restriction imposed by the multi-block structure of the resulting polyurethane. The occurrence of stereocomplexation significantly improved the crystallization ability of PLA-based polyurethane. The measurement on mechanical, shape memory, hydrophilicity and biodegradation properties of the resulting materials were conducted, and the results were discussed to correlate the varying compositions and the formation of stereocomplex crystals to these properties. It was identified that the increased stereocomplex crystallinity reduced the hydrophilicity and biodegradation rate of PLA-based thermoplastic polyurethane. The synthesized materials were also evaluated for their biocompatibility by in vitro hemolysis and cytotoxicity experiments which renders them as potential in-vivo implantable materials.
Incidence and Predictors of Dystocia of Active First Stage of Labor at Debremarkos Comprehensive Specialized Hospital Amhara, North West Ethiopia, 2022/2023
Authors: Nigussie Tirusew , Azanaw Getnet , Shumye Muhabaw
Published: July 2023

Background
Dystocia of active first stage of labor `has a notable contribution to maternal and fetal and / or neonatal morbidity and mortality. It is a main reason for the increasing rate of cesarean delivery in the world. Majorities of the determinants of dystocia in active first stage of labor could be modifiable, and may vary across the settings and over time trend. So, contextual scientific studies in this regard are imperative for evidence-based interventions. However, there was a dearth of evidence about extent and contributing factors of dystocia of active first stage of labor in Ethiopia.
Objective
This study aimed to assess the incidence and predictors of dystocia of active first stage of labor among laboring women at debremarkos comprehensive specialized hospital Amhara, northwest Ethiopia, 2022/23.
Methods
Prospective cohort study was conducted among 656 laboring women from October 20 to January 4/2023. The study participants were selected by using a systematic random sampling technique. Data were collected through observation, interview using a pretested structured questionnaire, and document review. Both descriptive and inferential analyses were carried out. Binary Logistic Regression was fitted and the level of significance was declared based on Adjusted Odds Ratio (AOR) with its 95% Confidence Interval (CI) and p-value of ≤ 0.05.
Result
The overall incidence of dystocia of AFSOL was 35.3%( 95%CI: 31.9, 39.2). Induction of labor (AOR: 2.5; 95%CI: 1.23. 5.42), admitting of laboring mother with cervical dilation of < 4cm (AOR: 2.9; 95%CI: 1.72, 4.93), poor health care provider support (AOR: 7.5; 95%CI: 4.18, 13.67), and caffeine intake > 200mg (≥ 3cup of coffee) (AOR: 3.7; 95%CI: 1.80, 7.74), Drinking of linseed (AOR: 0.28; 95%CI: .14, .55), ANC follow up (AOR: .24; 95%CI: .09, .63), and ambulation during AFSOL (AOR: 0.31; 95%CI: .13, .69) were predictors of dystocia of active 1st stage of labor.
Conclusion
The incidence of DAFSOL was high. Having ANC follow up, eating/drinking of linseed at the onset of labor pain and ambulating during active first stage of labor, drinking of three or more cup of coffee per day during pregnancy, induction of labor, poor health care provider support during AFSOL and admitting of the laboring mothers while cervical dilation < 4cm were predictors of DAFSOL. Adopting WHO labor care guide and encouraging health care providers to practice evidence based practice regarding the management of active 1st stage of labor and good patient handling during the laboring process is recommended to minimize the diagnosis of DAFSOL and its unnecessary interventions.
Batch-Corrected Distance Mitigates Temporal and Spatial Variability for Clustering and Visualization of Single-Cell Gene Expression Data
Authors: Chen Ken , Liang Shaoheng , Dou Jinzhuang , Iqbal Ramiz
Published: July 2023

Clustering and visualization are essential parts of single-cell gene expression data analysis. The Euclidean distance used in most distance-based methods is not optimal. The batch effect, i.e., the variability among samples gathered from different times, tissues, and patients, introduces large between-group distance and obscures the true identities of cells. To solve this problem, we introduce Batch-Corrected Distance (BCD), a metric using temporal/spatial locality of the batch effect to control for such factors. We validate BCD on simulated data as well as applied it to a mouse retina development dataset and a lung dataset. We also found the utility of our approach in understanding the progression of the Coronavirus Disease 2019 (COVID-19). BCD achieves more accurate clusters and better visualizations than state-of-the-art batch correction methods on longitudinal datasets. BCD can be directly integrated with most clustering and visualization methods to enable more scientific findings.
Proteomics analyses of five potential plasma-derived exosomal biomarkers for acute myocardial infarction
Authors: Xu Shasha , Zhai Yi , Wang Chen , Zhang Yang , Liu Xiaowei , Jiang Jianjun , Mi Yafei
Published: July 2023

Acute myocardial infarction (AMI) is considered to be one of the most common cardiovascular complications. Recently, various research studies have shown that exosomes play a significant rolein the development and progression of cardiovascular diseases. However, there is still a lack of relevant research on the relationship between plasma exosomes and AMI. This retrospective study investigated the base date of patients with AMI(n = 20), stable angina pectoris (SAP, n = 20), and noncoronary heart disease (CON, n = 20). Proteomics was used to systematically screen the differential proteins of plasma exosomes in patients with clinical AMI, SAP, and CON. Then, the results were further verified by parallel reaction monitoring (PRM) and ELISA . Among the differential expression proteins, 5 proteins were quantified by PRM. Compared with the CON group, heparin cofactor 2 (SERPIND1), mannan-binding lectin serine protease 1 (MASP1), ficolin-2 (FCN2), and α1-Microglobulin/bikuninprecursor (AMBP)were upregulated in AMI and SAP, and they were more highly expressed in AMI than in SAP. Additionally, human leukocyte antigen (HLA-C) was found to be downregulated not only in exosomes, but also in plasma. The expression of four plasma exosomes biomarkersin AMI patients and stable angina pectoris (SAP) was higher than that in noncoronary heart disease (NCHD) patients, and HLA-C was found to be downregulated not only in exosomes, but also in plasma. The obtained results serve as anew candidate targetfor the detectionand therapyof AMI.
Markedly Low Prevalence of Fatty Liver despite Obesity in Prader-Willi Syndrome: A Search for Protective Genetic Markers
Authors: Murik Omer , Gross-Tsur Varda , Mann Tzvia , Zeevi David A. , Baraghithy Saja , Altarescu Gheona , Tam Joseph , Hirsch Harry J. , Shteyer Eyal
Published: July 2023

Background & Aims.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in all ages that may cause significant morbidity and mortality. The pathogenesis of the disease is not fully elucidated but genetic factors have a major role in the development of NAFLD. Prader-Willi syndrome (PWS) is a neurogenetic, multisystemic disorder in which the main symptom is lack of satiety with uncontrolled eating and severe obesity. Despite obesity, NAFLD is relatively rare in PWS. The aim of this study was to assess whether known NAFLD-associated small nucleotide variants (SNVs) play a role in the protection from NAFLD in PWS.
Approach & Results.
Using targeted amplicon next generation sequencing, we studied DNA from patients with PWS and genotyped 13 SNVs that were previously associated with high risk for NAFLD. The study population included 142 (69 females) individuals with genetically confirmed PWS. Median age was 17.5 years, BMI z-score was 2.13 ± 1.9 and mean ALT and AST were 22 ± 20 units/L and 29 ± 17 units/L, respectively. Five of the 13 SNVs showed significantly lower frequency of the risk allele in our cohort compared to healthy population frequencies. Cumulative risk score for all 13 SNVs was also significantly lower in our cohort of PWS patients compared to the healthy population (adjusted p-value, 1.85E-5). Furthermore, it was found that Ashkenazi Jews have lower frequency of the risk alleles of NAFLD.
Conclusions.
Our results show that genetic factors may protect patients with PWS from developing NAFLD. Larger scale studies should be performed to confirm our findings.
Measuring Outcomes of Educational Activities with a Novel Virtual Patient Simulation-Gamification Platform
Authors: Iancu Igal , Zehavi Liron , Kaminer Ofek , Draznin Boris
Published: July 2023

Background The goal of continuing medical education (CME) is to help healthcare providers (HCP) improve their knowledge and levels of competency and enhance their professional performance in practice. Despite the long history of the CME and the CME-like programs, proof of their success in demonstrating improved clinical outcomes has been difficult to obtain. Lately, digital encounters of virtual patient simulation (VPS) have disrupted medical education, replacing traditional presentations followed by multiple-choice questions as a means of assessing learning and progress.Methods The most current VPS applications can deliver educational activity in an engaging, “video game-style” way, allowing practice in a safe environment, and providing individualized detailed analysis of potential outcomes. We utilized the advanced VPS gamification platform (Edocate Ltd., Ramat Gan, Israel) to analyze the outcomes of educational activities offered in various settings. We analyzed the data collected by the platform in real-time that provide an objective picture of the learner’s performance of physical examination, diagnostic considerations, prescription patterns of various medications, appropriateness of laboratory and imaging investigation, referral patterns, and adherence to guidelines and best practices.Results Three virtual patient scenarios (obesity and type 2 diabetes) were offered to the learners with the time interval between the cases varied from 1 day to 6 weeks, 10 days on average, allowing us to assess the durability of the acquisition of knowledge. This CME activity was tested in 126 physicians and 261 advanced practice providers. Data analysis identified gaps in knowledge and competence, adherence to the most recent guidelines, selection and application of auxiliary tests, referral pattern to specialists, as well as prescription patterns and familiarity with medications and their side effects. From the learner’s side, utilization of VPS resulted in improved performance from one case to another. From the program host’s point of view, the advanced VPS platform allowed the development of measurable, detailed insights into what learners have done individually and as a group.Conclusions This study demonstrates the effectiveness, advantages, and limitations of the VPS-gamification platform in assessing knowledge gaps, performance, prescription patterns, and clinical competency improvement among learners.
Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites
Authors: Gazdik Tana R. , Crow Jacob J. , Lawton Tyler , Munroe Chloe J. , Theriault Hannah , Wood Travis M. , Albig Allan R.
Published: July 2023

Notch signaling is universally conserved in metazoans where it is important for a wide variety of both normal and abnormal physiology. All four mammalian Notch receptors are activated by a conserved mechanism that releases Notch intracellular domains (NICDs) from the plasma membrane to translocate to the nucleus. Once there, NICDs interact through highly conserved ankyrin domains to form head-to-head homodimers on Notch sensitive promoters and stimulate transcription. Due to the highly conserved nature of these Notch ankyrin domains in all four mammalian Notch proteins, we hypothesized that NICDs may also engage in heterodimerization. Our results reveal the presence of two NICD dimerization states that can both engage in homo and heterodimerization. Using a Co-IP approach, we show that all NICD’s can form non-transcriptionally active dimers and that the N4ICD appears to perform this function better than the other NICDs. Using a combination of ChIP analysis and transcriptional reporter assays, we also demonstrate the formation of transcriptionally active heterodimers that form on DNA. In particular, we demonstrate heterodimerization between the N2ICD and N4ICD and show that this heterodimer pair appears to exhibit differential activity on various Notch sensitive promoters. These results illustrate a new diversification of Notch signaling mechanisms which will help us better understand basic Notch function.
Study on design of conical arc side-edge milling cutter and cutting performance under the ultrasonic vibration assisted condition
Authors: Wang Guangyue , Xu Wenyuan , Li Chunhui , Liu Jiaming , Chen Tao
Published: July 2023

Titanium alloy aviation structural parts are one of the critical parts of the aircraft, with complex thin-walled cavity structure, many kinds of surfaces. For the surface side milling finishing most of the use of ball end milling cutter, but there are some problems in the machining process, such as poor cutting conditions at the bottom of the end teeth, small cutting speed and small chip space. Given the above issues, the research on the design and manufacture of conical arc side-edge milling cutter for titanium alloy processing was carried out in this paper; the mathematical model of the vital structure of conical arc side-edge milling cutter was established; the grinding trajectory equations of tool front and flank were deduced; the tool-workpiece kinematics of ultrasonic vibration applied to conical arc side edge was studied; and the comparative experimental study of the conical arc side-edge milling cutter cutting titanium alloy with and without ultrasonic vibration assistance was carried out. The experimental results show that ultrasonic vibration reduces cutting force, tool wear, and chip plastic deformation.
Managing climate risks: New evidence from integrated analysis at the basin scale
Authors: Baccour Safa , Albiac Jose , Ward Frank , Kahil Taher , Esteban Encarna , Uche Javier , Calvo Elena , Crespo Daniel
Published: July 2023

Safe, reliable, and equitable water access is critical for sustaining healthy livelihoods. Climate water stress is a growing challenge internationally making it difficult to achieve sustainable management of river basins. Addressing the problem requires integrated multi-sector water management strategies for climate resilience. The Water-Energy-Food-Ecosystems (WEFE) nexus offers promise as a comprehensive framework to guide science-based plans to achieve sustainable development goals. Several nexus approaches have been proposed in previous works. However, none to date has conceptualized, formulated, tested, validated, and applied a comprehensive dynamic optimization framework that includes several water-using sectors including ecosystems for a significant river basin supporting livelihoods of large numbers of people. The original contribution of this paper is to make headway on filling these gaps, taking Spain’s Ebro Basin as a case study, providing evidence to guide science-based policy reform. This work’s innovations illustrate the previously untested use of information to guide proposed water allocations among several economic sectors including protection of key ecological assets. Results provide a rigorous framework for measuring the level and distribution of benefits and costs among sectors and stakeholders. Findings reveal a range of policy choices that improve the hydrologic and economic performance of water management compared to the current policy for addressing climate change. Policy options that systematically account for the full range of benefits of environmental flows guide science-informed strategies for guiding climate resilience planning. They can increase stream flows in rivers, enhance water security and biodiversity, and reduce the economic burdens imposed by climate risks.