bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemberitaan Umat Islam Melalui Kantor Berita Internasional Pada Surat Kabar Terbitan Medan
Authors: Setiawan Daryanto
Published: July 2021

Penelitian ini bertujuan untuk mengetahui pemberitaan umat Islam melalui kantor berita internasional pada surat kabar terbitan Medan. Metode yang digunakan dengan pendekatan kuantitatif dalam bentuk analisis statistik yang bersifat deskriptif dan tabulasi silang­. Surat kabar yang digunakan dalam penelitian ini adalah Surat Kabar Waspada dan Sinar Indonesia Baru yang diakses melalui situs online surat kabar Waspada dan Sinar Indonesia Baru. Hasil penelitian menujukkan bahwa bahwa 1) Frekuensi berita tentang umat Islam yang diliput oleh saluran berita internasional yang disiarkan secara online melalui surat kabar Waspada dan Sinar Indonesia Baru rata-rata satu sampai dua judul setiap hari, 2) Mayoritas berita tentang umat Islam adalah hasil dari saluran detikcom (CNN) asal negara Amerika Serikat yang menjadi saluran berita utama surat kabar Waspada dan BBC asal negara Inggris yang menjadi saluran berita utama surat kabar Sinar Indonesia Baru, 3) Negara yang paling banyak diberitakan adalah Arab Saudi, Palestina, Malaysia, Pakistan dan Indonesia, dan 4) Kategori berita yang paling banyak adalah peperangan, kematian, dan kerusuhan sehingga orientasi berita pada umumnya adalah bersifat negatif yang dapat membanguan pandangan negatif tentang umat Islam.
Dakwah Kultural Nilai-Nilai Kearifan Lokal: Ajaran Sunan Muria Di Kampung Budaya Dawe Kudus
Authors: Ahmad Nur , Nafis Umi Zakiatun
Published: July 2021

Dakwah kultural sebagaimana yang dipraktikan oleh para ulama di Jawa pada masa lampau menjadi menarik untuk dikaji bahkan diimplementasikan dalam dakwah di era sekarang. Dakwah kultural Sunan Muria pun senantiasa direpresentasikan oleh Komunitas Kampung Budaya Piji Wetan (KBPW). Komunitas yang terletak di Desa Lau Dawe Kudus ini kembali membumikan ajaran dan nilai filosofi dari Sunan Muria yang kemudian dikemas secara bagus agar menarik minat masyarakat untuk kembali melirik kebudayaan Islam yang nyatanya telah hilang dari peradaban masyarakat. Hasil menunjukkan bahwa: pertama, agenda dakwah kultural di Kampung Budaya Piji Wetan yang mengadopsi ajaran Sunan Muria terbagi menjadi tiga bidang yakni: a) bidang seni dan budaya yaitu dengan program jagong tapa ngeli, tonilan, dan pager mangkuk; b) bidang pendidikan yakni menghadirkan agenda guru pagi dan taman dolanan; c) bidang ekonomi yakni dengan program pasar ampiran dan KBPW Store; 2) strategi dari Kampung Budaya Piji Wetan pula selaras dengan era sekarang yakni memanfaatkan media sosial untuk membumikan agenda KBPW dan ajaran Sunan Muria.
Konservasi Temuan Makam Kuno Keramat dan Perkembangan Islam di Medan
Authors: Sumanti Solihah Titin
Published: July 2021

the purpose of this research is to find out how the distribution of the existence of ancient tombs in the city of Medan, the form of management of ancient tombs in the city of Medan based on the Law of Cultural Heritage No. 11 of 2010, and the contribution of the findings of ancient tombs to the development of Islam in the Village Martubung Medan. The method used is transect walk. This method is carried out as a strategy to map the existence of cultural heritage from the existence of complexes of ancient tombs.  His findings that the identification of ancient tombs in the city of Medan, especially in Martubung village, namely the Tomb of Datuk Hasan, Tomb of Datuk Payung, Tomb of Datuk Tongah, Datuk Dadih and Tomb of Datuk Hitam. To maintain the cultural heritage, the government collaborates with local communities to conduct socialization and conservation activities that include physical protection, transfer, excavation and recording, maintenance. The discovery of five ancient Islamic tomb complexes in Martubung Village shows the historical events of the entry and development of Islam in North Sumatra and cultural changes through the process of human adaptation to the environment.
Prinsip Ekologis Untuk Kehidupan Berkelanjutan Perspektif Teologi Islam: Kajian Atas Kitab Rasail al-Nur Sa`id Nursi
Authors: Mudin Moh Isom , Zarkasyi Hamid Fahmy , Riyadi Abdul Kadir
Published: July 2021

Sa`id Nursi argues that nature and the environment have fixed principles that function to maintain the continuity of life while problems arise when the patterns of human environmental activity tend to contradict these principles so that life is threatened. This paper discusses the principles of ecology according to Sa`id Nursi as the basis for implementing the sustainable living agenda. Primary data of this qualitative study were obtained from Rasail al-Nurwhich was described as well as analyzed using a compare and contrast model with relevant environmental theories. The two findings of this study are that Nursi first built an ecological principle based on the tajalli principle of al-asma al-husna, namely cleansing (at-tandzif) the manifestation of al-Quddus, interdependence (at-tasanud) of al-Fard's manifestation, harmony (at-ta`awun) al-Fard, dynamic balance (at-iqtishad wa al muwawazanah) manifestation of al-hakim. Second, Nursi considers humans to be caliphs because they have the most perfect ecological elements in manifesting the attributes of Allah Almighty. Sa`id Nursi emphasized that the human community must maintain and implement this principle for the sustainability of the nature it occupies. The sustainability of life is directly proportional to the implementation of ecological principles.
The Models of Islamic Syiar Approach by the Religious Counselors in Developing Religious Life in East Lampung Regency
Authors: Mubasit Mubasit , Yanti Fitri
Published: July 2021

East Lampung has been known as one of the Muslim bases in the Lampung Province. However, problems faced by Muslims in this region are quite complicated. Some of these issues are demoralization and the highly rate of criminalization. This study aims to describe and analyse the models of Islamic syiar approach applied by the religious counsellors in East Lampung. This research uses the descriptive qualitative method. The data is collected through in-depth interviews with the informants who have direct relation to the religious counselling activities. Besides, the direct observation is involved in analysing the activities of religious counsellors in doing their Islamic syiar. Moreover, surfing related documents to obtain relevant data with religious counselling activities such as rules, policies, and provisions is also entangled. Based on the conducted research, the religious counsellors in East Lampung use three approaches in performing their syiar in their community. They are the socio-cultural approach, the psychological approach and the political approach.
Demokrasi Semu: Politik Pencitraan dalam Bingkai Islam dan Implikasi Terhadap Good Governance
Authors: Fithriyyah Mustiqowati Ummul , Astuti Atika Windi , Umam Muhammad Saiful , Wahyu Ningsih Risma Lutfia
Published: July 2021

 

PSEUDO DEMOCRACY: 

POLITICAL IMAGING WITHIN ISLAMIC FRAMEWORK AND IMPLICATIONS FOR GOOD GOVERNANCE

Indonesia, as a Muslim-majority country, weaponizes Islam in politics to win over the voices of Muslims in the country. This method is not allowed to be implemented in Indonesia which adheres to a democratic system. Principally, political imaging is carried out in order to influence society by instilling opinions. Regardless of the purpose of imaging, gaining public trust is way more important rather than just having a good image. Public trust is gained through the credibility of the candidates. The said credibility is achieved when the candidates act in a way that is in line with what they said or promised. Candidates can apply political imagery through good governance to gain public trust without having to accentuate the image of the politicization of Islam. This article aims to see how political imaging should be carried out from an Islamic perspective. The method used to study the problems is qualitative. The result of this study shows that the plurality that exists in Indonesia requires special attention from the government to manage the political religions which can create controversy between religious communities. In order to build an essential democracy in Indonesia and avoid the presence of political power of religious identity in the political arena, every candidate must avoid identity involvement in the electoral arena as a way of avoiding the awakening of identity and its sentiment that occurs in Indonesia.
HERMENEUTIKA NASHR HAMID ABU ZAYD: Analisis Hadis-Hadis Perceraian
Authors: Kurahman Taufik
Published: July 2021

Perceraian tentu tidak diharapkan oleh keluarga mana pun, kecuali jika memang keadaan telah mendesak. Bahkan, Nabi menjelaskan bahwa meskipun perceraian adalah perkara yang diperbolehkan, namun ia merupakan masalah yang paling dibenci Tuhan. Dua persoalan yang selalu dibahas adalah tentang hak mengajukan perceraian dan konsep talak tiga, yang hingga kini dirasa lebih menguntungkan pihak suami. Artikel ini bertujuan mengkaji kembali beragam hal pokok dalam masalah perceraian yang berkaitan dengan tatanan masyarakat modern. Beberapa masalah yang dimaksud adalah hak menginisiasi perceraian, maksud talak tiga, dan rujuk. Hermeneutika Nashr Hamid Abu Zayd digunakan sebagai pisau bedahnya. Penggunaan hermeneutika Abu Zayd dalam masalah perceraian dianggap sesuai karena hermeneutikanya dikembangkan untuk menjawab kesenjangan-kesenjangan sosial dan HAM, khususnya hal-hal yang berkaitan antara laki-laki dan perempuan, sebagaimana yang dicontohkannya dalam masalah poligami dan hak waris. Dengan menggunakan teori lima konteks hermeneutika Abu Zayd, yaitu konteks sosio-kultural, konteks eksternal, konteks internal, konteks bahasa, dan konteks takwil, penelitian menghasilkan kesimpulan bahwa Islam tidak menghendaki perceraian. Bahkan, dalam bahasa yang lebih ekstrim, dapat dikatakan bahwa perceraian dilarang dalam agama Islam. Nas-nas Islami menunjukkan bagaimana perceraian menjadi pilihan terakhir bagi hubungan suami-istri.

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Nashr Hamid Abu Zayd’s Hermeneutics: Analysis Hadiths of Divorce. It is not expected by any family, unless the circumstances have been urgent. The Prophet explained that although divorce is a permissible issue, it is a decision that God hates the most. Two issue that are always discussed by scholar in this issue are the right to file for divorce and the concept of “talak tiga” (the third divorcing), which is considered favor husbands over wifes. The article was written to reexamine various main divorce issues in modern views. Some of the probles are the right to file for divorce, the purpose of talak tiga, and the reconciliation. For these purposes, the author uses Nashr Hamid Abu Zayd’s hermeneutics as a approach. The use of Abu Zayd’s hermeneutics is divorce issues is approriate, because his hermeneutics were developed to address the social and human right gaps, especially issues relating to men and women, as he exemplified in the problem of polygamy and inhertance rights. By using Abu Zayd’s theory of five hermeneutical contexts, namely the socio-cultural context, external context, internal context, language context, and takwil context, the research resulted in the conclusion that Islam does not want the divorce happen. Even, it can be said that divorce is prohibitted in Islam. Islamic texts show how divorce is the last option for a marriage relationship.]
Judicialização da saúde, acesso a medicamentos e diálogos institucionais
Authors: Rodrigues Daniel Dos Santos , Lima Jordão Horácio da Silva
Published: July 2021

O artigo buscou examinar os vínculos entre acesso à justiça e a efetividade de um dos aspectos do direito à saúde no Brasil, o acesso a medicamentos, a partir dos votos dos ministros do Supremo Tribunal Federal no Recurso Extraordinário nº 566.741/RN e à luz da compreensão e aplicação das teorias dos diálogos institucionais pela Suprema Corte. Discutiu-se que, de maneira geral, há apenas uma enunciação retórica das teorias dos diálogos institucionais (que valorizam, em regra, as capacidades institucionais de cada Poder e a autocontenção do Poder Judiciário) sem de fato aplicá-la. Nesse sentido é representativo o voto do ministro Luís Roberto Barroso, o qual, apesar de expressamente enunciar a aplicação das teorias dos diálogos, não as aplica para resolver o problema da usurpação das funções da Comissão Nacional de Incorporação de Tecnologias no SUS (CONITEC) pelo Poder Judiciário através dos Núcleos de Apoio Técnico ao Judiciário (NatJus), perpetuando a dissolução do direito constitucional a políticas públicas de saúde em um mero direito subjetivo a medicamentos. Concluiu-se que uma possível e definitiva solução dessa questão passa pelo aperfeiçoamento do accountability sobre o Poder Judiciário, de modo que, entre outras coisas, possa ampliar o compartilhamento das consequências políticas e econômicas de suas decisões com a sociedade.
Elementos para uma teoria da fundamentação da decisão administrativa: uma abordagem à luz da hermenêutica
Authors: Dezan Sandro Lúcio , Lopes Alexandre Dos Santos
Published: July 2021

O presente artigo, partindo de uma abordagem hermenêutica, pretende analisar, na ordem jurídica brasileira, o estágio de transformação normativa que repercute na fundamentação das decisões originárias do módulo processual administrativo (decisão de natureza jurídico-administrativa), para, em conclusão, tracejar os elementos introdutórios de uma teoria da fundamentação da decisão administrativa no direito brasileiro.
МЕНЕДЖМЕНТ ПОВЫШЕНИЯ КАЧЕСТВА ПРОДУКЦИИ В СОВРЕМЕННЫХ УСЛОВИЯХ ИЗДЕЛИЙ ЛЁГКОЙ ПРОМЫШЛЕННОСТИ
Authors: ДРОЗДОВА И. , ЧУРИЛИН А.
Published: July 2021

Качество – многосложное понятие, и его обеспечение требует объединение научных сил, от творческого потенциала до практического опыта многих специалистов. И при нынешней ситуации в России проблема качества не только важна, но и должна быть решена совместными усилиями государства, федеральных органов управления, руководителей коллективов предприятий, ученых, конструкторов, каждого инженера, рабочего, эксперта на местах. В статье рассмотрены методы повышения качества продукции в современных социально-экономических условиях.
ИНФОРМАЦИОННО-АНАЛИТИЧЕСКАЯ ПОДДЕРЖКА ПРИНЯТИЯ УПРАВЛЕНЧЕСКИХ РЕШЕНИЙ КАК ИНСТРУМЕНТ СОВЕРШЕНСТВОВАНИЯ ПРОЦЕССА УПРАВЛЕНИЯ СОЦИАЛЬНО-ЭКОНОМИЧЕСКИМ РАЗВИТИЕМ РЕГИОНА
Authors: КАПУСТА Б.
Published: July 2021

В статье рассматриваются возможности совершенствования процесса управления развитием региона при помощи информационно-аналитических систем поддержки принятия управленческих решений.
ИССЛЕДОВАНИЕ ТЕОРЕТИЧЕСКИХ И МЕТОДОЛОГИЧЕСКИХ ПОДХОДОВ К ИЗМЕРЕНИЮ ДОБАВЛЕННОЙ СТОИМОСТИ ГОТОВОЙ ПРОДУКЦИИ НА ОСНОВЕ СЫВОРОТКИ МОЛОЧНОЙ
Authors: БАХМАТОВА Е.
Published: July 2021

В статье обозначена ключевая роль показателя добавленной стоимости в оценке глубины и комплексности переработки сыворотки молочной. Исследованы теоретические подходы к определению содержания категории «добавленная стоимость». Проанализированы методологические подходы к измерению добавленной стоимости, систематизированы показатели оценки. В результате
сформулированы практические рекомендации по оценке добавленной стоимости готовой продукции на основе сыворотки молочной в Республике Беларусь.
РЕФОРМИРОВАНИЕ АГРАРНЫХ ОТНОШЕНИЙ В ПРОЦЕССЕ РЫНОЧНОЙ ТРАНСФОРМАЦИИ БЕЛОРУССКОЙ ЭКОНОМИКИ: ПУТИ СТАНОВЛЕНИЯ И РЕЗУЛЬТАТЫ
Authors: КРИВОШЕЕВА Л. , КРИЖАНОВСКАЯ Е. , ЧЕРНЯВСКИЙ М.
Published: July 2021

Статья отражает историю становления аграрного реформирования, происходящего в экономике Республики Беларусь, начиная с 80-х годов, – до настоящего времени. Объектом исследования является реформирование аграрных отношений и, в частности, их центрального звена - земельных отношений, в процессе рыночной трансформации. Рассмотрены основные законодательные акты, принятые за время аграрного реформирования, направленные на эффективное использование земель, приносящее экономический, социальный, экологический или иной полезный результат.
ФОРМИРОВАНИЕ КОНКУРЕНТНОЙ СРЕДЫ В ЖИЛИЩНОМ СЕКТОРЕ ЭКОНОМИКИ РОССИИ
Authors: МОРДОВЕЦ В.
Published: July 2021

В научной статье рассматривается жилищный сектор экономики России с позиции формирования конкурентной среды. Представлены основные направления демонополизации сектора. Выявлены направления развития конкурентной среды на основных рынках жилищного сектора. Предложены факторы конкурентоспособности хозяйствующего субъекта, осуществляющего деятельность в жилищном секторе
КОМАНДНАЯ ФОРМА ОРГАНИЗАЦИИ ТРУДА
Authors: ВОЛОДЬКО В.
Published: July 2021

В статье рассматривается современная популярная форма организации труда – командная. Показаны различия между профессиональными группами и командами, виды и характеристики команд, критерии их эффективности. Рассмотрены командные процессы: развитие, сплочение, формирование командного мнения, межличностные трения. Проанализированы преимущества и недостатки командной организации труда.
РЕГИОНАЛЬНЫЙ МОНИТОРИНГ ГОСТИНИЧНЫХ УСЛУГ В СИСТЕМЕ УПРАВЛЕНИЯ КОМПЛЕКСОМ ГОСТЕПРИИМСТВА В ГОРОДЕ И РЕГИОНЕ
Authors: МИХЕЕВА Н.
Published: July 2021

Необходимость создания регионального мониторинга гостиничных услуг обусловлена потребностью в научной обоснованности планов и программ дальнейшего развития системы гостеприимства в России и недостаточностью информации о состоянии гостиничного сервиса в городах и регионах. В статье раскрывается понятие регионального мониторинга, рассматриваются вопросы применения методов статистики, социологии и маркетинга для изучения существующей инфраструктуры гостиничных услуг, разработки карты регионального мониторинга, создания и постоянного функционирования научно-исследовательского или административного органа регионального мониторинга гостиничных услуг.
SPECIFICITY OF THE MINING INDUSTRY AS A TYPE OF ECONOMIC ACTIVITY
Authors: Mialeshka Yu.
Published: July 2021

The article is devoted to the study of the characteristics of the mining industry as a type of economic activity. The role of mining in modern industrial relations as a source of mineral resources, including fuel and energy, is shown. Thanks to taxes and resource rents, this industry is the absolute leader in the share of income redistributed in favor of the state budget. The conditions under which mining is a driver of sustainable economic development are identified. The author singles out and characterizes such distinctive features of the mining industry as a high level of costs due to natural factors, capital intensity, scale, long-term concentration of production, active participation of the state, and high volatility of prices for mining products.
CONCEPTUAL APPROACHES TO THE MAIN AREAS OF INDUSTRIAL COOPERATION WITHIN THE FRAMEWORK OF THE EURASIAN ECONOMIC UNION
Authors: Prasniakova A.
Published: July 2021

The article reveals the theoretical aspects of the interrelationship of integration processes and industrial development of the countries participating. The role of industry modernization in providing positive integration effects is shown. Based on the analysis of the dynamics of industrial production volumes of the EEU Member States for 2015–2019 a conclusion was drawn about the lagging growth rates in Belarus. The problematic issues of the functioning of Belarusian industrial organizations within the EAEU are reflected. Recommendations on the content of the Main Directions of Industrial Cooperation within the framework of the Eurasian Economic Union for the period up to 2025, which ensure the protection of producers of member states in the general market of integration associations and increase their competitiveness in the markets of third countries, are suggested.
Relación entre las características socioeconómicas y el logro académico de los estudiantes en la primera infancia en Colombia —2017—
Authors: Caicedo-Reyes Sara Sofía , Silva-Arias Adriana Carolina
Published: July 2021

El principal objetivo de esta investigación fue analizar las características socioeconómicas y el logro educativo de los estudiantes de primaria en Colombia para el año 2017. Para ello se describe el logro educativo y algunas condiciones del contexto individual, familiar y de la institución educativa de los estudiantes. Este análisis es relevante, dado que las desigualdades en las oportunidades educativas inciden en la calidad de vida de los estudiantes, ya que, entre otras cosas, condicionan su nivel de ingreso y bienestar en la vida adulta. Así, los resultados evidenciaron que las circunstancias que se encuentran fuera del control de los estudiantes, como, por ejemplo, la condición socioeconómica, estuvieron asociadas a su desempeño académico. Igualmente, un entorno desfavorable individual, familiar y en los colegios se asoció con un menor logro educativo. Por tanto, este estudio contribuye a visibilizar que el sistema educativo reproduce las inequidades educativas y sociales desde la educación básica primaria en Colombia.
¿Cumple el gravamen a los movimientos financieros en Colombia con los principios de regresividad y equidad?
Authors: Briceño-Forero Luisa Fernanda , Cañón-Moreno Andrés Felipe
Published: July 2021

Este trabajo analiza la evolución de los indicadores de productividad —efectividad de recaudo— y progresividad —aporte a la equidad— del gravamen a los movimientos financieros (GMF), con el fin de analizar si este impuesto ha cumplido con los principios tributarios de regresividad y equidad. El objetivo del estudio es realizar un análisis detallado de la estructura del GMF para el periodo 1999-2018 a través de la construcción del indicador de progresividad/regresividad y del indicador de productividad, para así visualizar el comportamiento del recaudo respecto al producto interno bruto. De igual forma, se busca ejemplificar través de un impuesto indirecto la senda que ha perseguido la política tributaria en Colombia entre 1999 y el 2018, la cual, de acuerdo con la Constitución Política de 1991, debe procurar aportar a la equidad. La teoría sugiere que los impuestos indirectos tienen ventajas en productividad del recaudo, pero efectos negativos en términos de progresividad. No obstante, los indicadores examinados para el impuesto del GMF sugieren una mejora en progresividad mientras su productividad se disminuye, lo cual demuestra que es un impuesto que sacrifica productividad para ganar progresividad.
Lidocaine Inhibited Migration of Non-Small-Cell Lung Cancer A549 Cells via the CXCR4 Regulation
Authors: Xing Baichun , Yang Linlin , Cui Yanan
Published: July 2021

BackgroundLidocaineis a local anestheticthat wildly used in surgical treatment and postoperative medical care for lung cancers.We hypothesized thatlidocaine at clinical plasma concentrationcan inhibit CXCL12/CXCR4 axis regulated cytoskeletal remodeling thereby decrease migration ofNon-small-cell lung cancers (NSLC) cells. MethodsWe determined the effect of lidocaine at clinical plasma concentration on CXCL12-induced cell viability, apoptosis, cell death, monolayer cell wound healing rate, individual cell migration indicators, expression of CXCR4, CD44, and ICAM-1, intracellular Ca2+level, and filamentous actin level alteration of NSLC cells A549 and CXCR4-knocked down A549 cells using CCK-8, Bcl-2 ELISA, Cell death ELISA, wound healing assay, chemotaxis assay, western blotting, QPCR, Fura-2-based intracellular Ca2+assay, and Fluorescein Phalloidin staining respectively.﻿ResultsLidocaine did not affect cell viability, apoptosis, and cell death but inhibited CXCL12-induced migration,intracellular Ca2+ releasing, and filamentous actin increase. Lidocaine decreased expression of CXCR4, increased CD44, but had no effect on ICAM-1. CXCL12induced the increase of CD44 and ICAM-1 but did not affect CD44 in the presence of lidocaine.The knockdown of CXCR4 eliminated all the effects of lidocaine.ConclusionLidocaine at clinical plasma concentrations inhibited CXCL12-induced CXCR4 activation, thereby reduced the intracellular Ca2+-dependent cytoskeleton remodeling, resulting in slower migration of A549 cells.
SARS CoV 2 Nsp5 Protein Causes Acute Lung Inflammation, a Dynamical Mathematical Model
Authors: Bensussen Antonio , Díaz José , Buylla Elena R. Álvarez
Published: July 2021

In the present work we propose a dynamical mathematical model of the lung cells inflammation process in response to SARS-CoV-2 infection. In this scenario, our model suggests that the main protease Nsp5 enhances the inflammatory process by increasing the levels of NF κB, IL-6, Cox2, and PGE2 with respect to a reference state without the virus. This overstimulated immune state becomes autonomous of the signals from other immune cells, and does not shut down by itself neither when the external signals are turned off. Our model suggests that Nsp5 is effectively the switch to start inflammation, the consequent overproduction of the ACE2 receptor, and an important underlying cause of the most severe cases of COVID19.
A Study of Cold Roll Forming Technology and Peak Strain Behavior of Asymmetric Corrugated Channels
Authors: Xu Chuntian , Wei Yifan , Pan Tuo , Chen Jianchao
Published: July 2021

The peak strain (PS) of sheet metal highly affects the process design and the quality of roll formed product. Different from the traditional roll forming technology (RFT) that all the cross section contours of the product are rolled simultaneously, a symmetric RFT is developed with respect to the corrugated channels under the study to avoid defects like tearing, twist and redundant deformations. The behaviors of their peak strains are subsequently simulated with Finite Element (FE), and the effects of three factors of the rolling speed, friction coefficient and the bending angle of roll are analyzed, respectively. Finally, both the rationality of RFT and the accuracy of final rolled product are verified by experiments. Results show that for two roll forming channels at the same time, even under the equal bending angles and the pressures of rolls, their maximum peak strains are also distinguished for their different channel widths. The maximum PS of the narrow channel is significantly larger than that of the wide, and the closer to the middle channel, the greater the PS of the narrow channel, which is on the right of bending angle of the trough. Moreover, the maximum PS is dominant by the friction coefficient and bending angle of the first forming pass. This can provide a reference in the design of RFT and improving the quality of the final rolled corrugated channels.
Fine Particulate Matter Pollution Characteristics and Source Apportionment of Changchun Atmosphere
Authors: Tang Jie , Yang Zhuo , Tui Yue , Wang Ju
Published: July 2021

In order to study the pollution characteristics and main sources of fine particulate matter in the atmosphere of the city of Changchun, PM2.5 samples were collected during the four seasons in 2014, and representative months for each season are January, April, July, and October. Sample collection was carried out on 10 auto-monitoring stations in Changchun, and PM2.5 mass concentration, and its chemical components (including inorganic elements, organic carbon, elemental carbon, and water-soluble ions) were measured. The results show that the annual average mass concentration of PM2.5 in Changchun in 2014 was about 66.77 µg/m3. Organic matter was the highest component in PM2.5, followed by secondary inorganic ions (SNA), mineral dust (MIN), elemental carbon (EC), and trace elements (TE). Positive Matrix Factorization (PMF) results gave seven factors, namely, industrial, biomass- and coal-burning, industrial and soil dust, motor-vehicle, soil and secondary-ion, light-industrial, and hybrid-automotive and -industrial sources in PM2.5, with contributing values of 18.9%, 24.2%, 5.7%, 23.0%, 11.5%, 13.0%, and 3.6%, respectively.
Endosomal Traffic And Glutamate Synapse Activity Are Increased In VPS35 D620N Mutant Knock-In Mouse Neurons, And Resistant To LRRK2 Kinase Inhibition
Authors: Kadgien Chelsie , Kamesh Anusha , Khinda Jaskaran , Cao Li Ping , Fox Jesse , Farrer Mathew J , Milnerwood Austen
Published: July 2021

Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson’s disease. Here, we study the basic neurobiology of VPS35 and Parkinson’s disease mutation effects in the D620N knock-in mouse and the effect of leucine-rich repeat kinase 2 (LRRK2) inhibition on synaptic phenotypes. The study was conducted using a VPS35 D620N knock-in mouse that expresses VPS35 at endogenous levels. Protein levels, phosphorylation states, and binding ratios in brain lysates from knock-in mice and wild-type littermates were assayed by co-immunoprecipitation and western blot. Dendritic protein co-localization, AMPA receptor surface expression, synapse density, and glutamatergic synapse activity in primary cortical cultures from knock-in and wild-type littermates were assayed using immunocytochemistry and whole-cell patch clamp electrophysiology. In brain tissue, we confirm VPS35 forms complexes with LRRK2 and AMPA-type glutamate receptor GluA1 subunits, in addition to NMDA-type glutamate receptor GluN1 subunits and D2-type dopamine receptors. Receptor and LRRK2 binding was unaltered in D620N knock-in mice, but we confirm the mutation results in reduced binding of VPS35 with WASH complex member FAM21, and increases phosphorylation of the LRRK2 kinase substrate Rab10, which is reversed by LRRK2 kinase inhibition in vivo. In cultured cortical neurons from knock-in mice, pRab10 is also increased, and reversed by LRRK2 inhibition. The mutation also results in increased endosomal recycling protein cluster density (VPS35-FAM21 co-clusters and Rab11 clusters), glutamate transmission, and GluA1 surface expression. LRRK2 kinase inhibition, which reversed Rab10 hyper-phosphorylation, did not rescue elevated glutamate release or surface GluA1 expression in knock-in neurons, but did alter AMPAR traffic in wild-type cells. The results improve our understanding of the cell biology of VPS35, and the consequences of the D620N mutation in developing neuronal networks. Together the data support a chronic synaptopathy model for latent neurodegeneration, providing phenotypes and candidate pathophysiological stresses that may drive eventual transition to late-stage parkinsonism in VPS35 PD. The study demonstrates the VPS35 mutation has effects that are independent of ongoing LRRK2 kinase activity, and that LRRK2 kinase inhibition alters basal physiology of glutamate synapses in vitro.
Comparison of Patient-reported Outcomes at 1 Year after Injury between Limb Salvage and Amputation: A Prospective Cohort Study
Authors: Kurozumi Taketo , Inui Takahiro , Nakayama Yuhei , Honda Akifumi , Matsui Kentaro , Ishii Keisuke , Suzuki Takashi , Watanabe Yoshinobu
Published: July 2021

Background: Owing to advances in knowledge and technology, salvaging the limbs of patients with severe trauma and injuries is possible. However, severe limb injuries occasionally necessitate amputation because it allows patients to regain their social lives earlier than limb salvaging. Moreover, previous related investigations are retrospective cohort studies or meta-analyses of retrospective studies, and prospective cohort studies of patient-reported outcomes are extremely rare. This single-center, prospective cohort study aimed to compare the patient-reported outcomes at 1 year after injury between limb salvage and amputation and to elucidate whether amputation contributes to early recovery of functionality and quality of life.Methods: We included 47 limbs of 45 patients with severe open fractures of the lower limb and categorized them into limb salvage and amputation groups. They were registered in the Database of Orthopedic Trauma by the Japanese Society for Fracture Repair at our center; data on patient-reported outcomes at 1 year after injury were obtained from this database. The mean patient age was 49.6 years. Patients’ limbs were evaluated using the lower extremity functional scale (LEFS) and Short-Form 8 (SF-8). Early recovery was evaluated using functionality and quality-of-life questionnaires. Nonparametric statistical analyses were conducted.Results: Of the 47 limbs, 34 limbs of 34 patients were salvaged and 13 limbs of 11 patients were amputated. Significant differences were noted between the limb salvage and amputation groups in terms of the LEFS scores (mean: 49.5 vs 33.1, P=0.025) and scores for the mental health component (mean: 48.7 vs 38.7, P=0.003), role–physical component (mean: 42.2 vs 33.3, P=0.026), and mental component summary (mean: 48.2 vs 41.3, P=0.042) of the SF-8. The limb salvage group had better scores than the amputation group. Conclusions: In this study, limb salvage results in better functional and mental health outcomes at 1 year after severe lower limb injury than after amputation. As reconstruction technology has advanced and limb salvaging has become possible, the focus of studies should now be based on the perspective of “how the patient feels”; hence, we believe that the results of this study, which is based on patient-reported outcomes, are meaningful.
Diode physical-limit-bandwidth efficient rectification
Authors: Gyawali Babita , Thapa Samundra Kumar , Barakat Adel , Yoshitomi Kuniaki , Pokharel Ramesh Kumar
Published: July 2021

Generally, a conventional voltage doubler circuit possesses a large variation of its input impedance over the bandwidth, which results in limited bandwidth and low RF-dc conversion efficiency. A basic aspect for designing wideband voltage doubler rectifiers is the use of complex matching circuits to achieve decade and octave impedance and RF-dc conversion efficiency bandwidths. Still, the reported techniques till now have been accompanied by a large fluctuation of the RF-dc conversion efficiency over the operating bandwidth. In this paper, we propose a novel rectification circuit with minimal inter-stage matching that consists of a single short-circuit stub and a virtual battery, which contributes negligible losses and overcomes these existing problems. Consequently, the proposed rectifier circuit achieves a diode physical-limit-bandwidth efficient rectification. In other words, the rectification bandwidth, as well as the peak efficiency, are controlled by the length of the stub and the physical limitation of the diodes.
Impact of The Arylation of N-Bridged Annulated BODIPY Dyes In Photophysical Properties
Authors: Mello Rodrigo Brito , Emery Flavio da Silva
Published: July 2021

Functionalization of BODIPY dyes is commonly used to modulate photophysical properties. Among the chemical modification of these dyes, ring fusion indifferent faces of dipyrromethene cores is gaining attention in the literature, due to the modulation ofemission/absorption properties and fluorophores with increased bright. N-bridged annulated BODIPYs were recently synthesized and shows intense bright and blu shifted emission. However, few examples of substituted compounds are described and none involving arylation with extention of the p-conjugation. In this manuscript, it is shown an optimized method for the synthesis of N-bridged annulated BODIPYs, including arylated derivatives, and the studies of molecular properties. It is also shown that fluorinated aryl substituted N-bridged annulated BODIPYs show high quantum yields and are red-shifted compared to unsubstituted examples. The work open opportunities for application of the new developed compounds as probes.
Learning High-Order Geometric Flow Based on The Level Set Method
Authors: Li Chun , Yang Yunyun , Liang Hui , Wu Boying
Published: July 2021

Recently, the development of deep learning (DL), which has accomplished unbelievable success in many fields, especially in scientific computational fields. And almost all computational problems and physical phenomena can be described by partial differential equations (PDEs). In this work, we proposed two potential high-order geometric flows. Motivation by the physical-information neural networks (PINNs) and the traditional level set method (LSM), we have integrated deep neural networks (DNNs) and LSM to make the proposed method more robust and efficient. Also, to test the sensitivity of the system to different input data, we set up three sets of initial conditions to test the model. Furthermore, numerical experiments on different input data are implemented to demonstrate the effectiveness and superiority of the proposed models compared to the state-of-the-art approach.
A High Resolution Coupled Ocean-atmosphere Simulation of the Regional Climate Over Central America
Authors: Misra Vasubandhu , Jayasankar C. B.
Published: July 2021

This study analyzes a relatively high resolution (15km grid spacing), regional coupled ocean-atmosphere simulation configured over Central America. The simulation is forced with global atmospheric and oceanic reanalysis for a period of 25 years (1986-2010). The spatial resolution and the time period of the Regional Climate Model (RCM) simulation are both unprecedented for the region. The highlights of the RCM simulation include the verifiable seasonal cycle of mesoscale features like the low level jets, the mid-summer drought and the seasonal tropical cyclone activity both in the Pacific and in the Atlantic Oceans. Similarly, the seasonal cycle of the robust surface ocean currents in the eastern Pacific and the Costa Rica Dome is also well captured in the RCM simulation. The RCM simulation also resolves the seasonal cycle of the Panama-Colombia Gyre, the Gulf of Papagayo and the Gulf of Tehuantepec Gyre. In many instances we find the RCM improves upon the global reanalysis forcing the simulation, indicating the potential value of dynamic downscaling. Furthermore, the co-evolving components of the atmosphere and ocean in the RCM is an added benefit to the atmosphere only and ocean only global reanalysis forcing the simulation. However, the model displays significant biases that manifest in precipitation, precipitable water, SST and winds which could potentially be improved.
Health Care Burden And Mortality of Acute On Chronic Liver Failure In Thailand: A Nationwide Population-Based Data
Authors: Chirapongsathorn Sakkarin , Poovorawan Kittiyod , Soonthornworasiri Ngamphol , Pan-ngum Wirichada , Chaiprasert Amnart , Phaosawasdi Kamthorn , Treeprasertsuk Sombat
Published: July 2021

Background: Accurate population-based data are required concerning the rate, economic impact, and long-term outcome from acute on chronic liver failures (ACLF) in hospitalized cirrhosis patients.Objective: We aimed to discover time trends for the epidemiology, economic burden, and mortality of ACLF in Thailand.Methods: We conducted a nationwide, population-based, cohort study which involved all hospitalized cirrhosis patients in Thailand during the period between 2009 and 2013, with data from the National Health Security Office. ACLF was defined by two or more extrahepatic organ failures in cirrhosis patients. Primary outcomes were trends in hospitalizations, hospital costs, together with inpatient mortality. Results The number of ACLF hospitalizations in Thailand doubled between 3,185 in 2009 and 7,666 in 2013. The average cost of each ACLF hospitalization was 3.5-fold higher than for cirrhosis (฿ 61,928 versus ฿ 16,995). The hospital is paid using a diagnosis-related group (DRG) payment system that is only 15% of the average treatment costs (฿ 9,371 from ฿ 61,928). The in-hospital fatality rate was 51% for ACLF while the additional fatality rate was 85% up to 1 year. The ACLF organ failure trends indicated sepsis with septic shock and renal failure as the majority proportion. Age, the number and types of organ failure and male sex were predictors of ACLF death. Conclusions and Relevance Cirrhosis and ACLF both represent substantial and increasing health and economic burdens for Thailand. These data can assist national health care policy stakeholders to target high-risk cirrhosis patients for care.
Moderate Intensity Treadmill Running Relieves Motion-Induced Post-Traumatic Osteoarthritis Mice by up-Regulating the Expression of lncRNA H19
Authors: Zhou Xuchang , Cao Hong , Wang Miao , Zou Jun , wu wei
Published: July 2021

Background The purpose of this study was to explore whether moderate-intensity exercise can alleviate motion-induced post-traumatic osteoarthritis (PTOA) and the expression change of lncRNA H19 during this progression.Methods Twenty-week-old male C57BL/6 mice were randomly divided into five groups: model control group (CM group, n = 6), treadmill model group (M group, n = 6), rehabilitation control group (CK group, n = 6), treadmill model + rehabilitation training group (K group, n = 6) and treadmill model + rest group (J group, n = 6). Paraffin sections were used to observe the pathological changes in the mouse knee joint in each group. A micro-CT was used to scan the knee joint to obtain the morphological indexes of tibial plateau bone. Real-time PCR was used to detect the mRNA levels of inflammatory factors, synthetic and catabolic factors in cartilage. Results After high-intensity exercise for four weeks, the inflammation and catabolism of the mouse knee cartilage were enhanced, and the anabolism was weakened. Further study showed that these results were partially reversed after four-week moderate-intensity training. The results of hematoxylin-eosin staining confirmed this finding. Meanwhile, high-intensity exercise reduced the expression of lncRNA H19 in cartilage, while the expression of lncRNA H19 increased after four weeks of moderate-intensity exercise.Conclusion High-intensity treadmill running can cause injury to the knee cartilage in C57BL/6 mice which leads to PTOA and an decrease of lncRNA H19 expression in cartilage. Moderate-intensity exercise can relieve PTOA and partially reverse lncRNA H19 expression.
Sorption And Physicochemical Properties of A Phosphorylated Mercerised Cotton Cellulose
Authors: Solovov Roman , Perevoznikova Anfisa Yu. , Seliverstvov Alexander F. , Shapagin Alexey V. , Fedoseev Alexander M. , Milutin Vitaly V. , Ershov Boris G.
Published: July 2021

A process of a mercerised cotton cellulose sample phosphorylation has been investigated. After oxidation a phosphorus content was determined by spectrophotometric analysis and it was in a range of 0.179 to 0.950 mmol g–1. A significant decrease in the tensile strength of the sample was found upon an increase of phosphoric acid concentration in a phosphorylating solution. Phosphorylated mercerized fabric contents more phosphorous as unmercerized fabric in 3 times. The sorption properties of phosphorylated cotton cellulose in aqueous solution containing Cu2+ were characterized. The maximum of static exchange capacity was found to be 1.48 ± 0.11 mmol g–1 for phosphorylated cotton with content 0.898 ± 0.090 mmol g–1 of phosphorus. The sorption of Cu2+ by single phosphorus-containing group occurs for samples with not exceeding 0.80 mmol g–1 of phosphorus. The preliminary studies of uranium(VI) micro quantities of radionuclides 241Am, 233U and 239Pu sorption from aqueous solution with phosphorylated textile demonstrated the high efficiency.
Genetic Relationship Between Interleukın-6 rs1800796 Variants, Interleukın-6 Plasma Levels and Susceptibility to Type 2 Diabetes Mellitus and Diabetic Nephropathy
Authors: COBAN Nezaket , Bayramoglu Aysegul , TEMIZ Zeynep
Published: July 2021

Type 2 diabetes mellitus (T2DM) is very common worldwide and genetically heterogeneous. One of the microvascular complications is diabetic nephropathy (DN). In recent years, T2DM has been described as a disease caused by chronic inflammation. The imbalance between pro- and anti-inflammatory cytokines causes inflammation. One of the candidate genes associated with T2DM and DN is the Interleukin-6 (IL-6) gene, one of the pro-inflammatory cytokines. This study was conducted to determine the polymorphism frequencies of the IL-6 gene rs1800796 and investigate the role of this polymorphism in the development of T2DM and DN. Genomic DNA that was obtained from 261 people was used in the study. IL-6 gene rs1800796 polymorphism was determined using the PCR, restriction fragment length polymorphism (RFLP) and electrophoresis. IL-6 gene PCR products were discontinued by treatment with restriction enzyme BsrBI and were analyzed in 2% agarose gel electrophoresis. IL-6 (Bioassay technology laboratory, Shangai, China) level was examined by enzyme-linked immunosorbent assay (ELISA) using a commercial kit. The results were statistically analyzed. The frequencies of rs1800796 genotypes were found to be GG 70.7%, GC 28.5%, CC 0.8% in the control group and GG 87.8%, GC 9.9 %, CC 2.3% in T2DM patients. Although there was a statistically significant difference between the control group and the T2DM patient group in genotype and allele frequencies, there was no significant difference in DN. The G allele frequency was also significantly higher in the T2DM group (p=0.000). IL-6 levels were determinated increased in patients with Type-2 diabetes compared to the control group. However; there was no significant statistically. We can say that IL-6 rs1800796 polymorphism is related to T2DM and G allele can be used as a useful genetic marker; this polymorphism is not related to DN, though.
Analyzing Sex-Differences in Atrial Fibrillation Patients: Bias or Proper Management?
Authors: Israeli Asaf , Gal Danna , Younis Autba , Ehrenberg Scott , Rozner Ehud , Turgeman Yoav , Koren Ofir
Published: July 2021

Background: There are inconsistent and conflicting data among males and females with AF. Objective: This study intends to analyze whether the sex-based differences among AF patients were influenced by age, co-morbidities, and treatment strategy rather than solely gender difference. Methods: We analyzed 327 consecutive patients admitted to the ED due to AF for three years and follow-up for a year. Results: Females with AF were older (p<.001), had higher BMI (p<.001), and a higher rate of co-morbidities as hypertension (p<.001), hyperlipidemia (p=0.01), Diabetes mellitus (p=0.05), valvular heart disease (p=0.05) and thyroid dysfunction (18.3% vs. 1.8%, p<.001). AF males had a higher rate of coronary disease (p<.001) and heart disease with reduced ejection fraction (p<.001). As a result, the mean CHADS2 and CHA2DS2-VASc scores were significantly higher in females (p<.001 for both). Female tends to be treated with rate control medications and less with antiarrhythmic agents (p<.001). Univariate analysis reveals that females had a higher rate of recurrent AF, heart failure hospitalization, CVA, and myocardial infarction. Yet, adjusting gender to age and co-morbidities shows that the females remain to have a higher rate of heart failure hospitalization (OR 2.73 95%CI 1.04-5.89, P-value <.001) and recurrent AF (OR 3.86, P-value =0.02). Thyroid dysfunction and the lack of antiarrhythmic treatment significantly increase the risk of AF (OR 5.95 95%CI 3.15-9.73, OR 3.42, respectively, P-value<.001 for both) regardless of gender. The mortality rate differs only in a sub-group of females ≥ 75 years of age (OR 1.60, P<.001). Conclusion AF males and females differ significantly in baseline characteristics. Females are older, have more co-morbidities, and tend to be treated unnecessarily differently for AF. Following age and co-morbidities adjustments, a female gender remains significant for heart failure hospitalization and recurrent AF. Thyroid dysfunction and AF treatment may explain the sex-based difference of recurrent AF.