bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacognostic, Phytochemical and Antimicrobial Study of Vidangadi Churna - An Experimental Study
Authors: Chhaju Ram Yadav  , Chudasama Hardik Y
Published: August 2024

Herbal medicines are gaining more and more attention all over the world as they have been in use since ancient times and have no side effects if taken under proper supervision. But they have their own limitations as data about standardization and quality control are not widely available. Therefore, it is the need of the hour to revalidate this herbal compound under the lens of advance tools or procedures. Method: Vidangadi Churna was prepared according to the classical reference. Physiochemical and Phytochemical study was performed by proper WHO guidelines and Antimicrobial activity of Vidangadi Churna was tested by Agar well diffusion method. Result and Discussion: In this study Vidangadi Churna showed the presence of phytochemical constituents having antimicrobial properties. This preparation was treated with different reagents and examined under UV light. Different reagents showed different colours of the preparation at different wavelengths. Various physiological active compounds like phenolic compounds, Tannins, Amino acids, alkaloids etc. were found in Vidangadi Churna. Antimicrobial study revealed the activity of this drug on different micro-organisms. Conclusion: Vidangadi Churna is poly-herbal Ayurveda formulation described in Yogratnakar in Kustha Roga Chikitsa Adhyay. By this study it is concluded that Vidangadi churna fulfilled all the standard criteria with effective parameters and it could be used as anti-microbial agent against infections caused by Klebsiella aerogenes, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.
Unhappy Pictures of Shift Drivers and Proposed Model of Chronoclinic
Authors: Kavita Mudagalla  , M.R.Sajjanshetty
Published: August 2024

“Shift work is commonly associated with health problems resulting in circadian misalignment and sleep restriction. Specially shift drivers, are affected by insomnia and up to 90% report regular fatigue and sleepiness at the workplace. According to Ayurveda, Nidra vega dharana/ Ratri jagarana causes Rookshata and Vataprakopa which leads to Vishamata in Doshas and Dhatus. Epidemiological data shows that shift workers are at increased risk of both physical and psychological health problems and shift work disorders (SWSD). These conditions typically lead to reduced work performance, road accidents, absenteeism and reduced quality of life. Given these wide spread and debilitating consequences there is an urgent need for treatment that help to improve the sleep and functional performance of the shift working drivers. The most common non pharmacological recommendations are, well planned shift scheduling, bright light exposure, napping, psychological counselling and education promoting sleep hygiene, and cognitive behavioural techniques. Along with these, implementation of chronoclinics and chronotherapy is very much needed. This article is dealing with deleterious consequences of shift work and some positive ways to optimize shift schedule and some recommendations to improve their health and sleep.
Management of Vicharchika Kushta through Ayurveda
Authors: Chetana S Mugali  , Sanath Kumar D G
Published: August 2024

Skin disorders in Ayurveda have been mentioned under the broad heading of Kushta. There are 18 types of Kusta which are classified as Maha kushta and Kshudra kushta. Vicharchika is the type of Kshudrakushta. Vicharchika kushta is characterized by symptoms like Kandu, Srava, Pidaka and Shyava varna. Vicharchika is often correlated to eczema based on the clinical presentations. There is no specific treatment or definite cure for Eczema in modern medical science, except some of the symptomatic treatments like application of topical steroid. These steroids cause some serious health hazards like suppression of the hypothalamic pituitary- adrenal axis and even cushingoid features. Whereas Ayurveda has specific treatments like Shodhana and Shamana type of therapies which manages the disease without causing any side effects to the body. In present case report a patient complaints of blackish lesions with itching and discharge since 2 years was treated with Shodhana (Vamana, Virechana) and Shamana aoushadhi, shown a significant results.
FACTORS AFFECTING NURSING STUDENTS’ DIGITAL BURNOUT LEVELS DURING IN PANDEMIC: A WEB-BASED CROSS-SECTIONAL STUDY
Authors: Terzi Banu , Azizoğlu Fatma , Seven Çağla
Published: August 2024

Aim: To identify factors affecting the digital burnout levels of nursing students during the pandemic period.
Method: The descriptive and cross-sectional study was conducted with 1000 nursing students. Data of the research was collected between March-April, 2021 as online survey by using “Introductory Information Form” and “Digital Burnout Scale”. In addition to descriptive statistical analyses, Kruskal-Wallis test and Dunn-Bonferroni test were used for the comparison of non-normally distributed quantitative variables between more than two groups. Spearman correlational analysis was used for evaluating the relationships between quantitative variables. Statistical significance level was accepted as p < 0.05.
Results: Regarding the Digital Burnout Scale scores of the students, average total scores were 2.70±0.92 (Min.=1-Max.=5, Median=2.67) for “Digital Aging” dimension, 3.17±1.06 (Min.=1-Max.=5, Median=3.33) for “Digital Deprivation” dimension and 2.76±0.93 (Min.=1.17-Max.=5, Median=2.67) for “Digital Exhaustion” dimension. Average total score of the overall scale was 2.83±0.86 (Min.=1.04-Max.=5, Median=2.79).
Conclusions and Suggestions: Nursing students experienced high level of digital burnout during the pandemic. The year of study of students and the time they spend on digital environments affects the level of digital burnout. Measures should be taken to reduce digital burnout during the distance nursing education.
Perancangan Aplikasi Chatbot Melalui Media Whatsapp pada Toko Sembako
Authors: Damara Rivaldi Garindra , Fitrani Arif Senja , Eviyanti Ade
Published: August 2024

Seiring dengan kemajuan ilmu pengetahuan, peran teknologi dalam meningkatkan aktivitas terkait pekerjaan menjadi sangat penting. Tugas-tugas manual yang tradisional kini semakin digantikan oleh sistem komputerisasi untuk meningkatkan daya saing dan keuntungan bisnis. Transisi ini didukung oleh penggunaan sistem Pesan Instan modern, seperti WhatsApp Messenger, yang memfasilitasi berbagi informasi terkait transaksi secara efisien. Manajemen inventaris yang efektif sangat krusial untuk keberlanjutan bisnis, memastikan penanganan stok yang akurat dan tepat waktu. Penelitian ini bertujuan untuk mengembangkan sebuah aplikasi yang mengelola inventaris di rak penjualan dan memberikan peringatan ketika stok menipis, sehingga memungkinkan pengisian ulang tepat waktu untuk menjaga operasi bisnis yang berkelanjutan.
Aplikasi Iuran Sampah Menggunakan Metode Web Development Life Cycle Berbasis Web dan Whatsapp
Authors: Fanani Muchammad Ichsanuddin , Astutik Ika Ratna Indra , Eviyanti Ade
Published: August 2024

Desa Siwalanpanji terletak di Kecamatan Buduran, Kabupaten Sidoarjo, Provinsi Jawa Timur. Didalam desa ini sering terlambat membayar petugas pembersihan, dikarenakan telatnya para pengurus menyetorkan kepada desa, penarikan iuran masih manual menggunakan kertas dan dibagikan ke rumah para warga. Haltersebut menjadi lamanya pengumpulan iuran sampah. Berdasarkan masalah yang ditemukan, sebuah solusi masalah yang ditemukan adalah dengan merancang bangun aplikasi iuran sampah berbasis web yang dapat berjalan di berbagai browser. Aplikasi ini dirancang menggunakan Web Development Life Cycle yang dimana akan melalui proses pengumpulan data hingga perancangan aplikasi. Aplikasi ini dapat melakukan pendataan pembayaran, penagihan iuran dengan notifikasi, support pembayaran online, mengirim bukti pembyaran dengan notifikasi. Hasil akhir dari proses implementasi dalam bentuk pemrograman PHP, JS, dan hasil uji coba menggunakan black box. Dengan adanya aplikasi web ini iuran sampah Desa Siwalanpanji dapat lebih terarah dan menjadi desa dengan perkembangan teknologi saat ini.
Pengembangan E-Modul Interaktif Pada Mata Pelajaran Administrasi Jaringan di SMK
Authors: Hamidah Luluk Nur , Hasanah Fitria Nur
Published: August 2024

Tujuan penelitian ini adalah untuk mengembangkan e-modul interaktif pada mata pelajaran Administrasi Jaringan Komputer dan mengetahui kelayakan e-modul untuk menciptakan proses belajar yang menarik bagi siswa. Penelitian Research and Development (R&D) menggunakan model ADDIE  yang terdiri dari 5 tahapan yaitu analyze, design, development, implementation, dan evaluation. Pada tahap pengembangan media tahap ini didesain dengan software Adobe Flash CC 2015. Dari hasil validasi yang sudah diberikan oleh alhi media diperoleh hasil 95% dengan keterangan e-modul interaktif sangat layak digunakan, dan adapun hasil presentase kelayakan yang sudah melalui uji coba kepada siswa memberikan hasil secara keseluruhan mendapatkan nilai 85% dengan keterangan e-modul interaktif sangat layak digunakan pada mata pelajaran administrasi jaringan.
Dampak Teknologi Komunikasi Terhadap Hubungan Antarpersonal Mahasiswa Dengan Dosen
Authors: Muharram M. Rizky , Prayoga Irham , Berasa Khairiya Wirda , Naibaho Sri Yusri , Harahap Nursapia
Published: August 2024

Tujuan penelitian ini adalah untuk menganalisis persepsi mahasiswa dalam mengetahui dampak teknologi komunikasi terhadap hubungan interpersonal antara mahasiswa dan dosen. Sebab pada generasi sekarang, cara pelajar berkomunikasi dengan dosen melalui teknologi komunikasi menggunakan ponsel pintar seringkali melanggar nilai-nilai etika dan sopan santun. Metode penelitian ini adalah analisis deskriptif kuantitatif. Penelitian ini dilakukan di Universitas Islam Negeri Sumatera Utara. Subyek dalam penelitian ini adalah mahasiswa UINSU jurusan Ilmu Komunikasi Stambuk angkatan 2022 yang berjumlah 40 orang. Hasil respon responden yaitu orang yang mempunyai pengalaman hubungan interpersonal dengan dosen melalui media sosial sebanyak 40 orang dari 10 pertanyaan, 63,56% dengan kriteria setuju. Artinya, hasil penelitian yang diambil menunjukkan berasal dari orang-orang yang mempunyai pengalaman hubungan interpersonal dengan dosen.
The Role Of Social Workers In Low Vision Rehabilitation Services At The Worth Foundation
Authors: Yudistira Thomas , Hastin Trustisari
Published: August 2024

Low vision is a form of visual impairment that limits daily activities and cannot be corrected with glasses, contact lenses, medication, or surgery (Jennifer Hissett 2008, 1032-33). Social workers have unique abilities in carrying out their role as professional experts in implementing low vision services at LAYAK Foundation's. One of the social institutions in Jakarta that participates in the implementation of social welfare that raises the issue of low vision is Yayasan Pelayanan Anak dan Keluarga (LAYAK). So the researcher wants to see what role social workers can play in helping low vision disabilities overcome limitations through the LAYAK Foundation's rehabilitation services. Research using qualitative methods using observation techniques, interviews and also using documentation studies, researchers focus the problem on the role of social workers carried out in rehabilitation services at LAYAK Foundation. Based on Walter A Fridlander's theory, the role of social workers is divided into 7 roles, namely as a catalyst, informator, mediator, motivator, counselor, facilitator and educator. In the research findings, it can be concluded that the role of social workers in increasing client independence in rehabilitation services at the LAYAK Foundation has advantages and disadvantages.
Propose Strategic Marketing Initiatives to Accelerate Market Share and Revenue of MEDTECH Company for Trauma Implant Device in Indonesia (Case Study at MEDTECH Company)
Authors:   School of Business Management, Bandung Institute of Technology, Indonesia, Nugroho, S.T. Aprianto Tri
Published: August 2024

Trauma is a critical global health issue, leading to millions of serious injuries and significant fatalities worldwide, particularly from traffic accidents. In Indonesia, traffic accidents were the fifth leading cause of death in 2023, highlighting the urgent need for effective trauma care. Despite the pandemic, the trauma device market in Indonesia experienced growth, with MEDTECH’s portfolio outperforming the market but still underperforming in revenue generation. This research aims to address MEDTECH’s challenges and formulate strategies to enhance its market presence and sales performance. The study is divided into three phases: identifying core business issues, establishing a theoretical foundation using PESTLE and Porter’s Five Forces, and conducting a SWOT analysis. The PESTEL analysis revealed opportunities such as economic growth and technological advancements, and threats including local content regulations and supply chain issues. The Porter analysis suggests moderate market attractiveness due to competition and innovation needs. The STP analysis identifies key targets, including Tier 1 hospitals for advanced Variable Angle (VA) implants and Tier 2 hospitals for cost-effective Mono Angle (MA) implants. The Marketing Mix analysis highlights the need for product updates, pricing adjustments, expanded distribution, and enhanced promotional activities. To strengthen its position, MEDTECH should focus on immediate product development and market penetration strategies, while also planning for long-term local manufacturing and regulatory compliance to ensure sustainable growth in the Indonesian market.
A City Image Study by Kevin Lynch’s Theoretical Approach: A Case Study of Pontianak City, West Kalimantan Province of Indonesia
Authors:   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145, M. R. S. Patamuan, , A. I. Naufal, ,   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145, D. N. Jeke, ,   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145, I. P. Hutagalung, ,   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145, I. Sasongo, ,   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145, L. Mulyadi, ,   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145, A. H. Heltra, ,   Department of Urban Planning and Design, Faculty of Civil Engineering and Planning, National Institute of Technology Malang, Malang, Indonesia – 65145
Published: August 2024

Pontianak City is the capital city of West Kalimantan Province reaches area coverage of 118.31 km2.This city has multiple functions as the government and economic centrals of the West Kalimantan Province of Indonesia. It is also known as the Equatorial city because it is located on the equator line and by the end of 2023, its population will reach 679.818 people and will become the 26th most populous city in Indonesia. The City of Pontianak located on the equator line with altitude height ranging from 0.1 to 1.5 meters above sea level, and from administrative divisions, Pontianak City consists of several district areas: (a) North Pontianak District, (b) East Pontianak District, (c) South Pontianak District, (d) Southeast Pontianak District, (e) the Pontianak City District, and (f) West Pontianak District, whether from geographical perspective, City of Pontianak is traversed by the longest river in Indonesia, the Kapuas River which has become a life support for the surrounding community. The analytical method applied in this research to study the city image of Pontianak is the triangulation method where it is used to compare information obtained through field observations with theoretical perspectives that have been studied previously. The result found in this article is the City of Pontianak has fulfilled the requirement of 5 elements of city image according to Kevin Lynch’s theory and it has Tugu Khatulistiwa or Equator Monument as a symbol or the icon of Pontianak City.
Stock Valuation of PT. Panca Budi Idaman, Tbk. (PBID) based on Free Cash Flow to the Firm and on Relative Valuation
Authors:   School of Business and Management, Institut Teknologi Bandung, Adiwijaya Adrianus Atma , Murtaqi Isrochmani ,   School of Business and Management, Institut Teknologi Bandung
Published: August 2024

The stock valuation of PT Panca Budi Idaman, Tbk. (PBID), an Indonesian plastic packaging manufacturer, is evaluated using the absolute and relative valuation. The absolute valuation is based on Discounted Cash Flow (DCF) method. In relative valuation, PBID is compared to its peers, which in this study are IPOL, PDPP, and TRST. Indonesia’s significant economic growth and the vital role of the plastic industry are noting strong demand for plastic packaging despite environmental challenges and regulatory pressures. Financial performance from 2017 to 2023 is assessed through profitability, liquidity, and solvency ratios, demonstrating PBID’s efficient operations and robust financial health. Future cash flows are projected, discounted using PBID’s Weighted Average Cost of Capital (WACC), and the terminal value is calculated. The intrinsic value is estimated at IDR 3,987 per share, indicating undervaluation compared to the current price of IDR 1,325 per share. Relative valuation compares PBID to industry peers using EV/EBITDA, P/E, and P/B ratios, reinforcing the undervaluation finding. Investment recommendations suggest PBID’s stock as a buying opportunity due to its strong market position and favourable valuation metrics.
Learning Transfer and Universal Grammar: The Case of Arabic as a Foreign Language
Authors:   Hassan II Institute of Agronomy and Veterinary Medicine, Rabat, Morocco, Imad Messouab
Published: August 2024

This Arabic as a Foreign Language (AFL) is considered a parsimonious field in applied linguistics. Therefore, this article tries to highlight how language transfer influences American students in their Arabic learning process. Additionally, this work attempts to explore whether Arabic foreign learners rely on their pre-existing knowledge to learn Arabic and determine the role of transfer regarding language universals. The study employs a quantitative methodology based on a Grammaticality Judgment Task (GJT) to achieve its objective. According to the study's results, L2 Arabic learners initially transfer their L1 setting to L2. In other words, Universal Grammar (UG) exists, but learners only have indirect access to it via their L1. By studying and investigating the influence of language transfer on learning outcomes, experts' and educators’ interventions can be tailored to more effectively assist foreign students in overcoming errors connected to their first language and improving their proficiency in learning Arabic language.
Applicability of Ujamaa Policy in Social Work Education in Tanzania Regarding Ubuntu Philosophy – A Literature Review
Authors:   Box 23409, Department of Sociology and Social Work, Faculty of Social Sciences, The Open University of Tanzania, Dar es Salaam, Tanzania, Lembuka Meinrad Haule
Published: August 2024

A literature review on the applicability of Ujamaa Policy in Social Work Education in Tanzania Regarding Ubuntu Philosophy. The late first president of Tanzania and Ubuntu champion (2014) Dr. Julius Kambarage Nyerere made deliberate efforts to decolonize education policy and systems in post-colonial Tanzania including education for self-reliance policy in 1967 under Ujamaa policy. Ujamaa is among the core values of Ubuntu philosophy that influenced social work education in Tanzania through the Ujamaa Intersections Model from pre-colonial to the present. In Ubuntu philosophy education is collectively developed and owned by the community and Tanzania’s social work education is integrated through the Ujamaa Intersections Model. Arusha Declaration of 1967 through the Ujamaa Policy strategically restored and integrated Social Work education through the Ujamaa Intersections Model that linked education and community. Compatibility of the Ujamaa Intersections Model and social work education facilitated self-reliance, voluntarism, community participation, cooperation, and empowerment by allowing community sections to take collective and holistic control of available resources for universal welfare. As per Ubuntu philosophy, the realization of Universal welfare in the country covered all community members regardless of their social status but emphasized vulnerable populations including orphans, disabled, elders, sick persons, pregnant women, etc. Over time, the applicability of social work education was in line with the Ujamaa Policy, and despite the colonial legacy in early social work programs, the content reflected the Ujamaa intersections Model. Ujamaa Policy addressed tribalism, and promoted national unity, solidarity, and cooperation spirit relevant to community development in the country, with more than 120 ethnic tribes requiring a comprehensive and collective cultural diversity social work relevant model of education to address existing social problems and collective sustainable future of Tanzania’s National Vision of 2050 and Sustainable Development Goals by 2030.
Career Awareness and Peer Social Support Woth Career Decision Making in College Students
Authors:   Master of Psychology, University 17 Agustus 1945 Surabaya, Bata Pricilla Rosdinata Lese Mari , Noviekayati IGAA ,   Master of Psychology, University 17 Agustus 1945 Surabaya, Pratitis Niken Titi ,   Master of Psychology, University 17 Agustus 1945 Surabaya
Published: August 2024

Indonesia is in the era of the industrial revolution 4.0 which causes a variety of new types of jobs to emerge. This condition makes students need to make the right career decision. This study aims to analyze the relationship between career awareness and peer social support with career decision making in college students. A quantitative approach was used in this study, involving 385 undergraduate students in Surabaya as samples, which were selected using the quota sampling technique. Data were collected through measurement scales that have been tested for validity and reliability, including the career decision-making scale, career awareness scale, and peer social support scale. Data analysis used multiple regression analysis. The results showed a positive and significant correlation between career awareness and student career decision making. However, peer social support had no relationship with students' career decision-making, indicating that students tend to rely on themselves in making career decisions. The findings provide practical implications for universities and counseling guidance services to increase students' career awareness to support appropriate career decision-making amid the growing needs of the job market.
Legality and Proof of Unwritten Agreements from a Civil Law Perspective
Authors: Agustini Shenti , Jaya Febri , Rusdiana Shelvi
Published: August 2024

Introduction: Making agreements in Indonesia can be done in written and unwritten form. This is in accordance with the principle of freedom of contract in the Civil Code. Unwritten agreements are also very often carried out in the business world because they are more efficient. However, unwritten agreements are problematic because they are very difficult to prove in civil court.Purposes of the Research: There are 2 (two) objectives in this research, namely first, to analyze the legal strength of unwritten agreements from the perspective of civil law books and second, to analyze evidence in civil courts for cases of breach of contract in unwritten agreements. Then to find the right legal solution in resolving default problems in civil court.Methods of the Research: The research method used in this research is normative juridical. This method uses literature study techniques. The type of data used comes from primary data, namely the Civil Code and legal principles, namely freedom of contract. then the secondary legal material used is in the form of previous research articles which examine the validity of unwritten agreements.Results of the Research: Based on the research results, it was found that unwritten agreements have binding legal force. However, in reality it is very difficult to prove it in court because evidence in civil law comes from written letters. Therefore, the solution that can be offered is the need for preventive and repressive legal efforts.
Potency of Cocoa Honey, Byproduct of Cocoa Bean Processing as Probiotic Media: Optimization of Saccharomyces boulardii Growth and Its Antimicrobial Activity
Authors: Yuliana Neti , Nurainy Fibra , Sumardi Sumardi , Marentina Zikrina , Putri Nabila Rizka
Published: August 2024

Cocoa honey, a byproduct of cocoa bean processing, contains high sugars and minerals; thus, it has potential as a fermentation medium. This research investigated the potency of cocoa honey as probiotic media for promising yeast probiotic Saccharomyces boulardii. The growth of S. boulardii in the cocoa honey medium was optimized through response surface methodology employing a central composite rotatable design to obtain maximum cell production and antimicrobial activity. The effects of inoculum size (2–5%), sucrose addition (2.0–3.0%), and fermentation time (5–20 h) were evaluated. The agar diffusion technique assessed the cocoa honey medium's antibacterial activity. Results showed that these independent variables significantly affected the production of S. boulardii cells and their microbial activity against Escherichia coli. The optimal values generated by the model with a desirability value of 0.908 were 20 h of fermentation time, 2% of sucrose addition, and 2% of inoculum size. The maximum yeast count (log10 8.07 cells/mL) and antibacterial activity (4.88 mm) were reached under these optimized conditions, which agreed with the predicted value of the RSM model. This study provided valuable information on the potency of cocoa honey as a fermentative medium for applying S boulardii to develop a probiotic drink.
Pensar e fazer a educação e formação humana em tempos de crise
Authors: Nedel Oliveira Victor Hugo
Published: August 2024

Trata-se de resenha crítica da obra "Educação e formação humana: práticas de enfrentamento em tempos de crise", de organização de CARVALHO, Maria Vilani Cosme de; MARQUES, Eliana de Sousa Alencar; ARAUJO Francisco Antonio Machado e publicada em 2020, pela EDUFPI.
Ferramentas educativas como recurso auxiliar para a doação de órgãos
Authors: Guedes Carneiro Caio , Souza Salomão Iago , Andrade Brandes Moura Ferreira João Pedro , Sarapeck De Carvalho Pinto Thalis , Pereira Adilson
Published: August 2024

Na atual realidade, para muitas pessoas, o transplante de órgãos se apresenta como oportunidade única de cura. E, apesar de se constituir parte crucial no processo resolução de diversas patologias, atualmente acontece em um número muito inferior ao idealizado. O presente artigo tem como objetivo analisar os motivos e as causas que compõem essa problemática, além de discorrer a respeito da eficácia da aplicação de ferramentas educativas como recurso auxiliar para fomentar a doação de órgãos por parte dos jovens. Para a realização da revisão integrativa, foram utilizadas 16 publicações, nacionais e internacionais, que abordam a temática e serviram para a análise, interpretação e coleta de dados referentes à doação de órgãos e suas mazelas. Nessa linha, tornou-se possível observar que o desconhecimento sobre o processo de doação de órgãos - que decorre de falhas na educação formal - tanto de profissionais de saúde como de estudantes da área é alarmante e constitui uns dos pilares que mitigam o crescimento do número de doadores de órgãos, entre outros fatores aludidos ao longo do artigo. Dentro desse cenário foi possível observar a eficácia de inúmeras ferramentas educacionais, tais como as HQs, na mudança de postura dos indivíduos não só em relação a possibilidade de entrarem na lista de doadores, como também na diminuição de estigmas negativos acerca do processo de doação e do transplante de órgãos. Apesar das evoluções supracitadas, tais recursos não são explorados e aplicados de forma ampla nacional e internacionalmente, e se apresentam como recurso a ser utilizado na soma de esforços aplicados para reduzir a lacuna entre a lista dos potenciais doares e dos que aguardam um transplante.
ПАРНЫЕ СЛОВА В КАРАКАЛПАКСКОМ ЯЗЫКЕ: ОБЗОР ОСНОВНОЙ ЛИТЕРАТУРЫ
Authors: Кдырбаева Бахытгуль
Published: August 2024

В этой статье анализируются парные слова с морфологической и фонологической точек зрения и рассматривается их взаимосвязь с редупликацией. Обсуждение этих тем поможет сформировать общее представление о парных словах в каракалпакском языке, выявить общие морфологические и семантические особенности. В завершение представлены окончательные выводы по исследованию.
ORNITONIM KOMPONENTLI MAQOLLARNING LINGVISTIK TADQIQI
Authors: Erdonova Muxlisa
Published: August 2024

ushbu maqoloda ingliz va oʻzbek tillaridagi ornitonim komponentli maqollarning lingivistik tadqiqi va oʻzbek va ingliz tildagi ramziy ifodasi haqida  ma’lumotlar keltirib oʻtilgan shu bilan birgalikda ularning tasviriy tahliy metod orqali ochib berishga harakat qilingan.
INNOVATSION YONDASHUV ASOSIDA MURABBIYLIK KOMPETENSIYASINI SHAKLLANTIRISH PEDAGOGIK ZARURAT
Authors: Nurumbekova Yarkinay
Published: August 2024

Ushbu maqolada boʻlajak mutaxassislarda innovatsion yondashuv asosida murabbiylik kompetensiyasini shakllantirish pedagogik zarurat ekanligi tushuntiriladi. Unda boʻlajak mutaxassislarda innovatsion yondashuv asosida murabbiylik kompetensiyasini shakllantirish mexanizmini takomillashtirish zarurati ta’lim va boshqaruv jarayonida jamiyat tomonidan belgilab berilgan qator xususiyatlarni oʻz ichiga oladi. Bular mustaqil fikrlaydigan, muvaffaqiyatga intiluvchi va mustaqil shaxs rivojlanish yoʻlini qura oladigan, davlat, jamiyat va ish beruvchilar talablariga javob beradigan, ijodkor, muloqotga ochiq, bitiruvchi shaxsni tayyorlash talabini bajarishda shularga e’tibor qaratiladi. . Bunda innovatsion usullar, murabbiylik texnologiyalari shaxsiy va kasbiy muvaffaqiyat bilan bogʻliq savollarni hal qilishda amaliy yordam beradi. Boʻlajak mutaxassislarda murabbiylik kompetensiyasini shakllantirish mexanizmini takomillashtirish vazifasini bajarishda ta’lim sifatini oshirish shartlari alohida oʻrganildi.
ОЛИЙ ТАЪЛИМ МУАССАСАЛАРИ ЎҚУВ МАШҒУЛОТЛАРИ ЖАРАЁНИДА ЗАМОНАВИЙ ПЕДАГОГИК ТЕХНОЛОГИЯЛАРДАН ФОЙДАЛАНИШНИНГ АҲАМИЯТИ
Authors: Эрназаров Алишер , Бекмурадов Зариф
Published: August 2024

Ушбу мақолада бугунги кунда мамлакатимизда таълим тизими ва унинг ривожланиши, олий таълим муассасалари ўқув машғулотлари жараёнида замонавий педагогик технологиялардан фойдаланишнинг аҳамияти муаллифлар томонидан ёритиб берилган. Қолаверса, замонавий педагогик технологиялардан фойдаланишнинг аҳамиятини ошириш бўйича таклиф ва тавсиялар ишлаб чиқилган.
Research and comparative assessment of bioaccumulation and negative effects during chronic inhalation exposure to nano- and microparticles of aluminum oxide in an experiment
Authors: Stepankov Mark S. , Zemlyanova Marina A.
Published: August 2024

Introduction. In connection with atmospheric air pollution by Al2O3 nanoparticles (NPs), which have physical properties different from microparticles (MPs), it is relevant to identify the key features of the negative impact of Al2O3 NPs during long-term inhalation intake.
The aim of the study. Research and comparative assessment of bioaccumulation and negative effects associated with Al2O3 nano- and microparticles chronic inhalation intake the body in an experiment.
Materials and methods. The physical properties of Al2O3 NPs were studied in comparison with MPs. Using Wistar rats, the distinctive features of bioaccumulation and negative effects associated with chronic inhalation exposure to Al2O3 NPs at a concentration of 0.017 mg/m3 for 180 days were determined.
Results. Al2O3 NPs have a smaller size, larger specific surface area and total pore volume, which contributes to their greater penetrating activity through protective barriers compared to MPs. Due to this, with the same range of biodistribution organs, NPs have a higher degree of bioaccumulation. Exposure to NPs causes redox imbalance, cytolysis, hepatotoxic effect, disruption of the processes of excitation and inhibition of the nervous system, and thrombocytosis. When exposed to MP, less pronounced redox imbalance, cytolysis, and disruption of the process of neurotransmission of excitation were noted. NPs cause pathomorphological changes in the form of inflammation and impaired blood circulation in lung tissues, impaired blood circulation in the brain and liver. When exposed to MP, only the development of an inflammatory process in the lungs was established.
Limitations. The study was carried out only with chronic inhalation exposure to Al2O3 NPs and MPs on Wistar rats.
Conclusion. Al2O3 NPs have more pronounced bioaccumulation, a larger spectrum and degree of manifestation of negative effects in comparison with MPs. It is advisable to use the obtained results to improve the effectiveness of scientific substantiation of recommendations aimed at preventing and minimizing negative health effects associated with chronic inhalation exposure to Al2O3 NPs.
Workplace factors affecting migrant workers' health
Authors: Barinova Vera V.
Published: August 2024

Introduction. Migrant workers are individuals who relocate from their country of origin to another to engage in economic pursuits. Working conditions, the work environment and process, lifestyle and habits of workers have an impact on the results of work and the health of workers. These factors are called risk factors and cannot be completely eliminated, but they can be controlled.
The aim of the study was to examine the actual factors affecting the health of migrant workers at the workplace.
Materials and methods. Eighty Korean compatriots from different countries who resides in “Korean Compatriot Village” were interviewed using a questionnaire. To analyze the survey results, the SPSS Statistics program, version 25, was used.
Results. Migrants who work more than 12 hours a day have worse health over time. Noise can cause health problems and diseases. Time for work and rest, work responsibilities affect weight gain and lead to health changes.
Limitation. Migrant workers weren’t asked about home country work experiences and start of work in Korean factories. The researcher didn’t know Korean factories well, hence detailed questions couldn’t be formulated.
Conclusion. Most respondents were young Korean compatriots who came to Korea to work. They experienced stress and fatigue due to the burden of responsibility and worry for their relatives. For elderly migrant workers it’s difficult to find work in home country and the problems with the musculoskeletal system occur due to their lack of work experience in such production and their advanced age.
Coping behaviour and defense mechanisms of nursing staff depending on the level of severity of emotional burnout
Authors: Pankov Vladimir A. , Kuleshova Marina V.
Published: August 2024

Introduction. Health care professionals’ (HCP) occupational activity is associated with a highly intense psycho-emotional load.
The purpose of the study is to identify the basic strategies of stress-overcoming behaviour in the cognitive, emotional, and behavioural spheres and the characteristics of defense mechanisms among nursing staff.
Materials and methods. An online study of coping strategies and defense mechanisms (DM) was carried out using E. Heim’s questionnaire, and method “Life Style Index”. The respondents were divided into two subgroups depending on the severity of emotional burnout (EB). Research results are displayed as median, upper and lower quartiles, and extensive indicators. The comparison of indicators was carried out using the χ2 criterion, the relationship between characteristics was assessed using correlation analysis, and the structure of the DM was studied using the factor analysis.
Results. Non-constructive and relatively adaptive copings predominate in the structure of cognitive strategies among HCP with an average and high level of EB. Adaptive copings predominate among emotional strategies in HCP with an average level of EB, and non-adaptive and relatively adaptive in HCP with a high
EB level. Non-constructive copings were in the majority among HCP with a high level of EB. The dominant MD among HCP with an average level of EB are “denial”, “repression”, “reaction formation”, and “regression”, “intellectualization”, “reaction formation” in HCP with a high EB level. The distribution of the largest weight loads in the MD complex is not identical; the common feature is the presence of “regression”, “compensation” in the first factor, “repression”, “response formation” in the second, and “denial” in the third.
Limitations. The study is one-stage, performed with the participation of one occupational group.
Conclusion. Non-adaptive, relatively adaptive cognitive and behavioural coping strategies predominate in the structure of coping behaviour among HCP with different levels of EB. The combination of MD in HCP with different EB levels is a key subsystem of interrelated functioning protective mechanisms that ensure the preservation of mental homeostasis and the integrity of the individual.
Quantitative assessment of the contribution of risk factors to the formation of nutrition-dependent diseases based on neural network modelling in schoolchildren
Authors: Zaitseva Nina V. , Kiryanov Dmitrii A. , Khismatullin Dmitrii R. , Chigvintsev Vladimir M. , Mustafina Ilina Z.
Published: August 2024

Introduction. The increased interest on the part of the state in the problem of healthy nutrition makes it urgent to develop methodological approaches to quantify the likelihood of the occurrence of nutrition-related diseases and assess health risks.
Materials and methods. The source of information was data obtained from a sociological study conducted by the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing (Rospotrebnadzor). For the analysis, there were used eleven thousand five hundred forty three questionnaires, characterizing the nutritional factors of schoolchildren in the Russian Federation in the regions. Associated relationships between the studied factors and morbidity were obtained through neural network modelling. The study of the contributions of factors to the formation of diseases was carried out based on the analysis of a simulation matrix containing 300 thousand possible nutrition scenarios.
Results. In the course of mathematical modelling, there were delivered 12 neural network models that describe the dependence of the additional probability of developing nutrition-dependent diseases on nutritional factors, characterized by a high proportion of correct predictions (more than 70%). The contributions of factors to changes in the probability of developing obesity were analyzed as a model with a high degree of reliability of parameters. The factors most influencing the development of obesity have been established to include daily consumption of foods with a high glycemic index, high-calorie confectionery in the form of cakes and pastries, sweet juices, consumption of products from a vending machine, excluding the purchase of salads and vegetable dishes. This type of diet increases the likelihood of developing obesity from the original 0.033 to 0.98 for the average schoolchild.
Limitations. The study is limited to a set of factors measured as a result of a sociological survey and used in training neural network models.
Conclusion. The neural network models obtained as a result of the study and the information materials created on their basis made it possible to develop tools that make it possible to quickly create arbitrary nutrition scenarios for schoolchildren and calculate the additional probability of the formation of nutrition-related diseases.
Features of TLR4 and MMP9 gene expression modified with SARS-CoV-2 antigen and benzapyrene in children
Authors: Zaitseva Nina V. , Dolgikh Oleg V. , Letyushev Aleksandr N. , Kazakova Olga A. , Ganich Tatiyana S.
Published: August 2024

Introduction. Exposure to chemical and biological environmental factors is associated with the risk of realizing genetic predisposition to the development of asthenia and cancer-associated diseases, which determines the relevance of the search for genetic indicator markers of early abnormalities in mRNA structure in the context of modern threats and challenges to public health. The aim of the study: characteristics of the expression of TLR4 and MMP9 genes modified by the SARS-CoV-2 antigen and benz(a)pyrene in children.
Materials and methods. We analyzed the polymorphism of MMP9 Gln279Arg (rs17576), TLR4 A8595G (rs1927911) genes, as well as the relative normalized expression level of MMP9 Hs00234579_m1 (20q13.12), TLR4 Hs00152939_m1 (9q33. 1) in whole blood cell culture both spontaneous and induced by 24 hour incubation with benz(a)pyrene and vaccine antigens (using SARS-CoV-2, 1.0±0.5•1011 particles as an example) in adolescents of 10–16-years.
Results. Benz(a)pyrene was found to have a potentiating effect on MMP9 expression and a suppressive effect on TLR4. The combination of benz(a)pyrene exposure with SARS-CoV-2 vaccine antigens “in vitro” resulted in differently directed effects depending on the genotype (polymorphism) of the genes under study. The ability of benz(a)pyrene and SARS-CoV-2 antigens to modify “in vitro” expression of MMP9, TLR4 candidate genes was shown, which allows considering genes and products of their expression MMP9 Hs00234579_m1 and TLR4 Hs00152939_m1 as indicator genes for early diagnosis of the development of asthenia and oncoproliferative states.
Limitations. Limitations of the study include the limited sample and scope of the pilot study.
Conclusion. The results of experimental studies ”in vitro” showed the ability of benz(a)pyrene and SARS-CoV-2 to modify the expression of genes of matrix metalloproteinase MMP9 Gln279Arg (rs17576) and toll-like receptor TLR4 A8595G (rs1927911), which allows considering transcripts Hs00234579_m1 and Hs00152939_m1 as criteria for the formation of asthenia in the course of viral infections (SARS-CoV-2) due to activation of the enzyme that destroys the extracellular matrix for AA wild-type and AG heterozygous genotype of the MMP9 Gln279Arg gene. In the case of heterozygous AG genotype of TLR4 A8595G gene, the combination of benz(a)pyrene and SARS-CoV-2 (26 serotype) leads to the formation of immunosuppression, which phenotypically may be accompanied by the development of oncoproliferative processes. MMP9 Hs00234579_m1 and TLR4 Hs00152939_m1 transcripts are recommended as markers of early disorders associated with SARS-CoV-2+benz(a)pyrene exposure.
Genotoxic effect of selenium arabinogalactan nanocomposite on nucleated blood cells
Authors: Tyutrina Vera A. , Sosedova Larisa M. , Titov Evgeniy A.
Published: August 2024

Introduction. Selenium (Se) nanoparticles have attracted the interest of researchers for various applications due to their unusual properties. Despite their advantages, Se nanoparticles also have toxic effects, so for their successful use it is necessary to know the doses that are safe for the use. An important component in the development of pathological processes is the occurrence of DNA damage after exposure to Se nanoparticles, which can lead to severe disorders.
Materials and methods. Male white rats were orally administered a solution of Se nanocomposite at a dose of 500 μg/kg for 10 days. The genotoxicity of the nanocomposite under study was assessed by the occurrence of DNA damage in blood cells using the DNA comet method in the alkaline version. The results were obtained during 2 stages: one day after exposure and after 4 months to identify the persistence or absence of a negative effect.
Results. With using the DNA comet method, intragastric administration of Se nanocomposite was found to cause the damage to the DNA structure, and this effect persists not only 24 hours after exposure, but also 4 months later.
Limitations. The study is limited to the study of DNA fragmentation on the next day after a 10-day exposure to Se nanocomposite in male white rats and during the long-term period after 4 months.
Conclusion. The study revealed persistent DNA damage in the nucleated blood cells of male albino rats, which apparently may be associated with the main mechanism of Se toxicity: nonspecific replacement of sulfur in sulfur-containing amino acids. However, the toxic effects of the nanocomposite may also be caused by its pro-oxidant properties, which requires further confirmation.
Management of socio-hygienic monitoring of the soil quality
Authors: Evseeva Irina S. , Ushakova Olga V.
Published: August 2024

Soil is the main factor in the preservation and accumulation of toxic compounds in nature that are resistant to the environment. Coming from the soil into adjacent environments, they lead to negative consequences for both human health and the environment. Approaches to the management of socio-hygienic monitoring of the soil quality currently require changes in the Russian Federation. During the study, normative and methodological documents regarding the conduct of socio-hygienic monitoring (SGM), forms of state sectoral reporting of the Russian Federation and the Republic of Belarus, State reports “On the sanitary and epidemiological situation in the Russian Federation” were studied, the following databases were used when conducting a literature search: Pubmed, Scopus, Web of Science, MedLine, Global Health, RSCI. During the analysis of industry reporting materials in the territories of the Russian Federation, the set of indicators for assessing the quality of soils in populated areas was revealed to be not sufficient, it does not take into account pollutants such as benz(a)pyrene. When conducting social and hygienic monitoring, a special place is also occupied by the choice of points for sampling soil for control, currently, such a significant object as landfills and landfills is not taken into account when choosing. The results of the study can only be used in the development of methodological documents for assessing the soil quality within the framework of the SGM, and are not applied to other facilities. The authors have proposed recommendations for expanding the range of indicators determined in the soil, changing the approach to managing monitoring on the ground. All this will make it possible to fully assess the possible risks to public health from the influence of soil pollutants.