bluuebunny/crossref_metadata_2025 huggingface dataset:
Internal Pressure Test on HDPE Pipe Ring
Authors: Manu Ioana Daniela
Published: October 2022

The purpose of experiment was the highlight of the creep of ring from polyethylene pipe subjected to internal pressure. To create the internal pressure in the HDPE pipe ring, a weight of 4.5 kg was superimposed on it, in the form of a cylindrical plate. In order to evaluate the strains of the elastic element subjected to the tensile stress, respectively compression, tensometric marks 1 and 2 are placed on the outside, in the case of the circular section. The internal pressure test was performed to evaluate the strains of the material of a PE 100 polyethylene ring in two directions: one axial (longitudinal) and the other transverse (circumferential) in order to highlight the creep of the pipe material due to its structure. In a polyethylene pipe stressed at internal pressure, due to the symmetry the tangential stresses are zero. The axial strain initially showed a positive increase, followed by a decrease, reaching negative values towards the end of the experiment, while the circumferential strain recorded positive values, about 300 times higher than the initial ones. The principal stress changed approximately linearly. The circumferential stress recorded the maximum value of σ1=0.33 MPa (3.3 bar) after two and a half hours of experiment. Based on such this test could be calculate Poisson s ratio ν.
Theoretical Prediction of Two-Peak Behavior of GFRP-Reinforced Concrete Compressive Members
Authors: Ouni Mohamed Hechmi El , Raza Ali , Arshad Muhammad
Published: October 2022

The use of fiber-reinforced polymer (FRP) composites in compressive members is advantageous to reinforced concrete structures in order to alleviate the problem of corrosion of steel reinforcement and to produce a lightweight and efficient structural element. This investigation aims to propose the theoretical models for capturing the axial loading capacity (ALC) of hollow concrete columns (HCCs) having main FRP rebars and transverse FRP spirals. All the glass-FRP-reinforced HCCs portray two-peak load performance. The first peak is due to the gross cross-sectional area of concrete while the second peak is due to the core material laterally wrapped with FRP spirals. For the prediction of the first peak load of HCCs which is equal to the maximum capacity of solid concrete columns, a database of 279 FRP-reinforced columns was produced from the previous research and the ALC models were suggested; one for capturing the first peak and the other for estimating the second peak ALC of HCCs. The predictions of proposed models were compared with the test results from the literature. A close relationship was perceived between the theoretical and experimental results.
Antitumor Effect and Pharmacological Mechanism of Paclitaxel-loaded Silk Fibroin Nanomaterials on H22 Subcutaneous Tumor Model of Mouse Hepatoma
Authors: Zhao Shengxing
Published: October 2022

This work was developed to analyze the adoption of paclitaxel-loaded silk fibroin nanoparticles (SFNPs) in subcutaneous transplanted tumor model of mouse hepatoma to explore its anti-tumor effect. Twenty-five specific pathogen-free (SPF) mice were selected to construct a subcutaneous tumor model of liver cancer, and they were randomly rolled into control group, group A, group B, group C, and group D, with five mice in each group. The silk fibroin was mixed with an organic solvent to prepare a suspension, and the SFNPs were prepared through centrifugation, ultrasound, and other methods. The paclitaxel-loaded SFNPs were prepared by mixing paclitaxel and silk fibroin aqueous solution, centrifuging, washing, and dispersing. Then, the five groups of mice were intervened by different dosage regimens to analyze the changes of various indicators. As a result, the prepared nanoparticles had uniform particle size, uniform distribution, no adhesion, and the average particle size was less than 500 nm. The tumor volume of mice in groups C and D on the 7th, 9th, and 13th days of administration were dramatically smaller than those in the control group, group A, and group B (P [ 0.05). And the tumor volume (154.49 � 9.65 mm3) of mice in group D on the 13th day of administration was dramatically smaller than that in group C (167.79 � 9.72 mm3) (P [ 0.05). The tumor mass (0.89 � 0.14 g, 0.54 � 0.13 g, and 0.46 � 0.11 g) of mice in groups B, C, and D was dramatically smaller than that in the control group and group A (1.23 � 0.12 g, 1.24 � 0.11 g) (P [ 0.05), and that of group D was dramatically smaller than groups B and C (P [ 0.05). The apoptosis rates of tumor cells in groups C and D (46.38%, 48.23%) were greatly superior to those in the control group (16.7%), group A (21.33%), and group B (35.6%) (P [ 0.05), and that of group D was greatly superior to that in group C (P [ 0.05). In summary, paclitaxel-loaded SFNPs can effectively improve the targeting effect and bioavailability of drugs in the treatment of liver cancer, thereby improving the efficacy, and had a good application prospect.
Asbestos-Free Brake Lining Material Using Sea Shell
Authors: Sankar Vijayasankar Vinayak Arun , Suresh Paramasivam
Published: October 2022

Due to the extreme health concerns associated with asbestos-based brake linings, researchers are looking at using ecologically friendly bio-based biomaterials as reinforcing agents in composite materials used to make brake pad linings. The goal of this study is to see whether using sea shell (SS) powder in the production of asbestos-free brake lining materials is feasible. The powders were combined with the necessary fillers to make the brake lining. The reinforcing powders compositions were varied between 20% and 35%, the resin binder s composition was changed between 58 and 43 percent, and the filler metal and curing agents compositions were kept constant. These ingredients were weighed, prepared, combined, cured, and moulded. The composite materials were tested for water and oil absorption, compressive strength, hardness, and wear. According to the findings, increasing the quantity of reinforcing components increases the water and oil absorption of the samples. With the addition of up to 35% content, the composite s compressive strength increased proportionally. The tested coefficient of friction was found to be within acceptable limits. Furthermore, when mixed with other fillers and restricted, SS powder has showed tremendous promise in the production of brake linings.
Mechanical Character Analysis of Pineapple Fibre Epoxy Composite with Nanoclay Quantity Variation
Authors: Murthy Prashanth , Bojan Sanjay Gandhi , Krishnasamy Senthilkumar
Published: October 2022

Epoxy based hybrid composites are extremely wide used materials in the polymer engineering field and always have a demand for their versatile applications. Nano clay is yet another trending substance handled by many researchers due to their enhanced abrasion characteristics. This research was performed to investigate the effect of dispersing nanoclay into epoxy matrix and further coupled with pineapple fibers to fabricate a hybrid composite of excellent mechanical property. 4 layers of Pineapple fiber mats were compression moulded with epoxy nanoclay blend to obtain composite specimens of 4mm thickness. Nanoclay was added into epoxy resin at four different weight ratios (2%, 4%, 6%, and 8%) to form four different combinations of matrix materials into which pineapple fiber mats were reinforced individually at a constant weight ratio of 25%. The enhancement of mechanical and abrasion rate of the hybrid composites were matched with those of the neat Epoxy/Pineapple fiber composites that are currently being developed as alternatives for brake pads. Moisture absorption rate of the composites were analysed to ASTM D570 and Morphology was inspected using Field Emission Scanning Electron Microscope (FESEM). The results depicted optimum mechanical performance at 4 wt% nanoclay infused epoxy/pineapple fiber composite that had a tensile strength of 166.75 MPa, flexural strength of 801.15 MPa and impact strength of 148.76 kg/sq. m. The least abrasion rate was detected in the composite with 8 wt% nanoclay content, resulting in an abrasion rate of 0.1064 g/m.
Design of Melamine Foam/perforated Plates Composite Absorber for Effective Sound Absorption Performance
Authors: Jiang Xueliang , Fu Qiang , Wu Dan , Tang Guijiang , You Feng , Yao Chu
Published: October 2022

To give full play to the advantages of perforated plate backed by porous materials in low and medium frequency noise absorption, this study uses Johnson-Champoux-Allard method with the finite element model to describe the acoustic characteristics of this composite structure. The effects of structural parameters of perforated plate and characteristic parameters of melamine foam on sound absorption coefficient were systematically investigated by numerical simulation. Practical composite were prepared to verify the reliability of the numerical simulation method. The simulation and experimental data in this study are helpful to promote the design of porous material-perforated plate structure for noise control in life.
The Application of N, N -bis(Isonicotinic Acid) 1, 4-Naphthalenedicarboxylic Acid Dihydrazide in Biodegradable Poly(L-lactide): Crystalline Nucleation, Melting Behavior, Thermal Stability and Mechanical Properties
Authors: Xia Hong-Xia , Cai Yan-Hua , Wang Jun , Huang Hao , Zhao Li-Sha
Published: October 2022

Improving the crystallization performance of poly(L-lactide) (PLLA) is necessary to adapt for various applications. In the current work, N, N -bis(isonicotinic acid) 1, 4-naphthalenedicarboxylic acid dihydrazide (NAIAH) was synthesized to be firstly aimed at promoting the crystallization of PLLA, and the NAIAH-nucleated PLLA materials were prepared using PLLA as a matrix material and NAIAH as a nucleating agent, and the crystalline nucleation, melting behavior, thermal decomposition and mechanical properties of PLLA/NAIAH samples were investigated by the relevant testing instruments. The results from the non-isothermal melt-crystallization from the melt of 190oC indicated that the NAIHA could significantly accelerate PLLA�s crystallization, and played an efficient heterogeneous nucleation in PLLA�s crystallization. The effect of different final melting temperatures on PLLA�s melt-crystallization behavior showed that a relatively low final melting temperature was beneficial for the crystallization of PLLA, and the 170oC was the optimum final melting temperature in this study. An increase of cooling rate could weaken PLLA/NAIAH�s crystallization ability, but the NAIAH was still able to promote PLLA�s crystallization upon the fast cooling at 50oC/min, showing a powerful crystallization accelerating effect of NAIAH. PLLA/NAIAH�s melting behaviors after different crystallization conditions were affected by heating rate and crystallization temperature, and the double melting peaks appeared in melting DSC curves were assigned to melting-recrystallization. Thermal decomposition processes in air showed that the NAIAH decreased PLLA�s thermal stability, but the interaction of PLLA with NAIAH had an inhibition for a drop in onset decomposition temperature. Additionally, the introduction of NAIAH dramatically reduced PLLA�s tensile modulus and elongation at break.
Performance Indicators for Water Supply in Buildings
Authors: Lourenço M. , Silva-Afonso A. , Pimentel-Rodrigues C.
Published: October 2022

Drinking water is a vital resource for the population’s quality of life and health. The satisfaction of their needs is increasingly demanding, essentially associated with the growth of the population's income and the possibility of improvements in terms of comfort, quality, and safety at lower costs. However, despite the accuracy of engineering design, the functional performance of the building's water networks does not always match the expectations because it can be subjected to failures, which can compromise other infrastructures and cause a lot of inconvenience to the residents or users. In this case, we can say that the water supply system is no longer reliable. In the study presented in this article, profiles were developed that make easier the assessment of the reliability of the installation, specifying key aspects involved, which may be called performance indicators. The indicators combined in a balanced way according to their importance make it possible to translate the relevant aspects regarding the operation of the water supply systems in the building and their reliability. In this sense, it is expected to contribute to the improvement and durability of building installations, regarding the water supply's performance, security, and quality.
Characteristics of Real Estate Investment by Value Type Cluster
Authors:   Korea Real Estate Society, Lee Hye Lee , Kim Jae Tae
Published: October 2022

The purpose of this study is to examine how the behavior of real estate investment differs according to different types of value clusters. The time of the research was in 2021, when real estate investment was very active and the research project was verified through descriptive statistics and regression analysis using the SPSS 23.0 statistical package.
As a result of the research analysis, the value type was classified into four groups: practicality-seeking type, success-seeking type, pleasure-seeking type and material-seeking type. For them, their financial attitudes (recognition of current and future financial possession, financial interest, and financial planning) had different influences on their real estate investment intention, which means each group showed specific aspects on the relationship concerned.
Based on this study, we can infer that financial attitude factors of different value types are different in the real estate investment market and the behavior of each cluster is expected to be utilized in providing customized services or developing marketing strategy of real state industry.
Analysis of the Importance of Factors influencing the Development of the Proptech Industry
Authors:   Korea Real Estate Society, Chu ChangUk , Yoo Seon Jong
Published: October 2022

The purpose is to contribute to analyze the importance and priority of factors that influence the development of the proptech industry.
According to the AHP analysis method, 3 major categories (internal factors, policy factors, environmental factors) and 6 medium categories (infrastructure, human resources, support, system, market , customer), and 18 sub-classifications, the evaluation model was designed.
Based on this model, as a result of empirical analysis of survey results conducted for experts in construction/development, finance/investment, brokerage/management, and other fields. By job field, construction/development and finance/investment occupations ranked policy factors the most. On the other hand, in brokerage/management and other occupations, environmental factors were considered the most important. By job type, environmental factors were considered the most important in the management/decision maker and project managers, while policy factors were considered the most important in business planning/development and other job types. By work experience, policy factors were considered most important for those with less than 10 years of experience, environmental factors from 10 to less than 20 years, and internal factors for more than 20 years of experience.
This study is different in that it comprehensively considers various factors and quantitatively analyzes the psychological factors felt by job field and type, work experience.
The Effect of Creative Ability of Certified Real Estate Agents on Nonfinancial Performance: Focused on the Mediating Effects of Market Orientation and the Moderating Effects of Education
Authors:   Korea Real Estate Society, Heo Yun Jo , Lee Choon Won
Published: October 2022

Business continuity of licensed real estate agents is deteriorating day by day due to lower brokerage commission rates, large companies entering the real estate brokerage market, and a sharp increase in the number of licensed real estate agents. Efforts are needed to improve nonfinancial performance in order for licensed real estate brokers to secure sustainability from a long-term perspective and promote stable projects. In addition, creative ability is strongly required for licensed real estate agents during the transition period of the information society and the post-industrial society. Reflecting this situation of the times, this study attempted to verify the effect of the creative ability of a licensed real estate broker on nonfinancial performance. In addition, based on the theoretical basis of related studies, the purpose of the study was established to verify the mediating effect of market orientation and the moderating effect of education in the relationship between these variables. The significance of causal paths between research variables was verified through statistical analysis after data collection for licensed real estate agents, and the main results of this study are as follows. First, it was found that creative ability had a positive effect on nonfinancial performance. Second, among the sub-factors of market orientation, information creation and response were found to have a significant mediating effect in the relationship between creative ability and nonfinancial performance, and this mediating effect was found to have the characteristic of a partial mediating effect. Third, it was found that the educational background of licensed real estate agents had a significant moderating effect in the relationship between creative ability and nonfinancial performance, and this moderating effect had the characteristic of reinforcing effect. Based on the results of these studies, this study made recommendations necessary to secure the business continuity of licensed real estate agents.
creciente relevancia del desarrollo sostenible en las estrategias globales de la Unión Europea
Authors: García Lupiola Asier
Published: October 2022

En lo que llevamos de siglo XXI la Unión Europea ha adoptado tres estrategias globales sobre crecimiento y desarrollo: la Estrategia de Lisboa, la Estrategia Europa 2020 y el Pacto Verde Europeo. Son planes generales para la coordinación de las acciones y políticas en los ámbitos económico, social y de empleo. El presente trabajo analiza la progresiva y creciente importancia que ha ido adquiriendo el desarrollo sostenible en cada una de dichas estrategias. Como se comprobará, inicialmente la sostenibilidad es tratada como una cuestión relevante pero accesoria en la Estrategia de Lisboa, pasa a ser un pilar determinante de la Estrategia Europa 2020 y con el Pacto Verde Europeo se consolida como principio que fundamenta de modo general el futuro inmediato del proceso de integración europea.
Notes on the biology of the Cretan frog Pelophylax cretensis
Authors: Moravec Jiří , Lymberakis Petros
Published: October 2022

Pelophylax cretensis is an endemic Cretan frog, whose biology has not still been studied in detail. Here we present some details regarding the hypsometric distribution and habitat requirements of P. cretensis that indicate this frog is an adaptable species, and can inhabit different types of water bodies up to 1330 m a. s. l.
Rekayasa Perangkat Lunak Pengolahan Klise Foto Menjadi Digital
Authors: Felisa Jenisa , Setiawan Dhanny , Stefani Kezia , Stevanus Andreas Fernando
Published: October 2022

Seiring dengan perkembangan jaman, penggunaan kamera analog sudah tergeser dengan penggunaan kamera digital. Begitu juga dengan percetakan klise foto dari kamera digital yang sudah sangat sulit dijumpai. Hal tersebut yang menjadi latar belakang dirancangannya aplikasi pengolah klise foto pada penelitian. Aplikasi pengolahan klise foto dapat digunakan untuk mengolah secara langsung gambar dari klise foto, yang dahulu harus melalui proses yang cukup panjang untuk dapat dicetak, menjadi lebih praktis dan cepat terkonversi kedalam bentuk citra digital. Penulisan aplikasi dilakukan dengan menggunakan bahasa pemrograman java dan juga menggunakan algoritma inverse matriks citra negatif. Pada pembuatan aplikasi ini juga akan diterapkan metode prototyping dimana terdapat gambaran awal perangkat dan adanya proses pengujian perangkat sebelum rilis. Aplikasi ini akan berjalan pada device android. Berdasarkan hasil penelitian yang telah dilakukan aplikasi dapat menampilkan tampilan gambar digital berwarna yang berasal dari gambar klise foto  negatif, dan dapat melakukan proses pengaturan gambar mendasar seperti crop, rotate, scale, brightness, contrast, dan kurva RGB.
Síndrome de Steven-Johnson y necrolisis epidérmica toxica: revisión bibliográfica actualizada
Authors: Falconí Chávez Darío Sebastián , Jami Carrera Jeanneth Elizabeth
Published: October 2022

La necrolisis epidérmica toxica (NET) y el Síndrome de Steven-Johnson (SJS) son trastornos de tipo mucocutaneos vesiculoampollosos agudos con alta tasa de mortalidad, el desenlace de esta patología depende en gran medida de que se identifique el agente causal lo más pronto posible, seguido de los cuidados de apoyo y el adecuado manejo de las heridas en una unidad de quemados .(Charlton et al., 2020)

Estas patologías se manifiestan con una fase prodrómica muy parecida a la influenza con malestar general, fiebre que luego comienza con dolor en membranas cutáneas y mucosas ya sea la ocular, genital u oral, para poder diferenciar estas patologías nos basaremos en el grado de afectación de la piel donde <10% corresponde a SJS, la NET se presenta con afectación >30% mientras que una superposición de SJS/NET va entre un 10-30% de afectación de la piel, en si el diagnostico de esta patologías se basan en la clínica así como una evaluación histopatológica.(Lerch et al., 2018)

 

A pesar de tener una alta tasa de mortalidad en los últimos años ha disminuido considerablemente, para determinar la gravedad se han empleado puntuaciones como la de SCORTEN que tiene un factor predictivo alto para la evaluación de la gravedad. (Lerch et al., 2018)

En los últimos estudios se ha determinado que el factor desencadenante son ciertos fármacos como las sulfonamias, fármacos antiepilépticos, antiinflamatorios no esteroideos, asi como el riesgo a reacciones de hipersensibilidad se han estado estudiando como posibles desencadenantes.(Noe & Micheletti, 2020)
Photocatalytic Degradation of Polyphenols and Polyaromatic Amines in Textile Industry Wastewaters by Nano-Cerium Dioxide Doped Titanium Dioxide and the Evaluation of Acute Toxicity Assays with Microtox and Daphnia magna
Authors: Rukiye Öztekin , Delia Teresa Sponza
Published: October 2022

In this study, nano-cerium dioxide doped titanium-dioxide (CeO2 -TiO2 ) Nanocomposites (NCs) was used for the photocatalytic degradation of pollutant parameters (color, polyphenols, polyaromatics) from a textile industry wastewater (TI ww) treatment plant located in Izmir, Turkey, at different operational conditions such as at increasing photocatalytic time (0, 10, 15, 20, 30, 60, 90 and 120 min), at different CeO2 -TiO2 mass ratios (1%, 3%, 5%, 10%, 15%, 16%, 25%, 30%, 50%), at the different amounts of CeO2 (1, 3, 5, 8, 10, 15, 20 and 25 mg/L) under 130 W Ultraviolet (UV) and 35 W sun lights irradiations, respectively. Color, polyphenols (quercetin, fi setin, ellargic acid, carminic acid, luteolin, and curcumin) and polyaromatics [2,6-dimethylaniline (2,6-DMA), 2-aminoanisole (MOA), 2,4-toluenediamine (TDA), 2-naphthylamine (NA), 4,40-thiobisbenzenamine (TOA), 3,3-dichlorobenzidine (DCB) and 3,30-dimethoxybenzidine (DMOB)] removal effi ciencies were observed between 78% and 99% during photocatalytic experiments, under ¬130 W UV light, at 15% CeO2 -TiO2 NCs, at 21° C, after 30 min irradiation time. 15% CeO2 -TiO2 NCs shows the highest photodegradation yield of color under both UV and visible-light irradiation, with maximum photodegradation rates of 99% and 98.5%, respectively, after 30 min irradiation time. 94.44% maximum Microtox acute toxicity yield was found in CeO2 -TiO2 NCs = 20 mg/L, at 5% CeO2 mass ratio, after 150 min photodegradation time at 60o C. 90% maximum Daphnia magna acute toxicity removal was obtained in CeO2 -TiO2 NCs = 20 mg/L, at 5% CeO2 mass ratio, after 150 min photodegradation time at 60° C. The results show that the CeO2 -TiO2 NCs has a high photocatalytic activity to remove the pollutants from TI ww.
Cystic Posterior Neck Mass in a Premature Newborn
Authors: Rivero Estephanie , Zauk Adel , J Pua Zarah
Published: October 2022

Congenital dermal sinus is a type of occult spinal dysraphism. It is a result of incomplete separation of the cutaneous ectoderm from neural ectoderm. MRI can aid in identifying the subtype of spinal dysraphism however, surgery is always recommended to dissect the intradural component.
Monkeypox and an Interesting Look at Changes in Epidemiology
Authors: Jesmin Subrina , Rahman Md. Arifur , Sohael Farzana , Shimojo Nobutake , Yamaguchi Naoto , Kawano Satoru , Moroi Masao
Published: October 2022

For decades, monkeypox virus was only a disease that infected animals but, in the 1990’s it found a new target in humans. This paper dives into the history of human monkeypox and the root of the cause right from the start. The aim here is to understand the underlying cause for the sudden rise in monkeypox cases in regions that are not conducive to the disease. Throughout the paper, there will also be a list of activities mentioned that people ought to avoid when a known person is infected. Overall, by the end of the paper there will be a clear idea of do’s and don’ts regarding monkeypox virus.
Obstructive Sleep Apnea Syndrome (OSAS) and Asthma: A Simple Association: A New Syndrome or a Cluster?
Authors: Antonaglia Caterina
Published: October 2022

Obstructive Sleep Apnea Syndrome (OSAS) and Asthma are two diseases with a high epidemiological impact that may coexist in some patients with the name of Alternative Overlap Syndrome. Both diseases have underlying pathogenic mechanisms (chronic inflammation, genetic predisposition etc). Epidemiological data suggest that the coexistence of OSA and asthma, also known as “Alternative Overlap Syndrome” has an adverse impact on health outcomes. Asthma and OSA overlap with similar comorbidities and underlying pathophysiology, potentiating the two conditions. The most common comorbidities associated with both diseases are Gastro-Esophageal Reﬂux Disease (RGE), rhinosinusitis and obesity. Neuromechanical reflex bronchoconstriction, local and systemic inflammation, the indirect effect on dyspnea of OSAS-induced cardiac dysfunction, angiogenesis and leptin-related airway changes may all play a common mechanistic role linking both disorders.
IDENTIFIKASI KUMARIN DAN PENGARUH JENIS PELARUT TERHADAP TOTAL KUMARIN PADA EKSTRAK BUAH API-API PUTIH (A. marina)
Authors: Febriani Alik Kandhita , Khairul Anam
Published: October 2022

Api-api putih (Avicennia marina) adalah salah satu jenis mangrove yang memiliki kandungan senyawa flavonoid, alkaloid, tannin, steroid, saponin, terpen, glikosida, dan kumarin. Pada tanaman api-api putih, kadar kumarin total tertinggi ada pada buahnya dibandingkan dengan daun dan kulit batangnya. Penelitian ini dilakukan untuk mengetahui kadar kumarin total ekstrak buah api-api putih yang diekstraksi dengan pelarut yang berbeda serta profil senyawa kumarin pada tiap pelarut menggunakan metode KLT. Ekstraksi dilakukan dengan metode sokletasi secara sekuensial dengan pelarut berturut-turut n-heksana, kloroform, metanol, dan air. Penentuan kadar kumarin total diukur menggunakan spektrofotometer UV-Vis pada panjang gelombang 274 nm. Total kumarin dinyatakan dalam mg CE (Coumarin Equivalent)/100 g ekstrak. Kumarin (1,2 benzopyrone) digunakan sebagai senyawa standar. Skrining fitokimia menunjukkan simplisia buah api-api putih mengandung alkaloid, tannin, saponin, flavonoid, dan steroid/triterpenoid. Ekstrak metanol merupakan ekstrak dengan rendemen terbanyak yaitu 22,22% diikuti dengan ekstrak air (12,77%), kloroform (0,48%), dan n-heksana (0,36%). Kadar kumarin total tertinggi yaitu 80,9 ± 1,4 mg CE/100 g ekstrak metanol diikuti dengan ekstrak air sejumlah 17,5 ± 1,4 mg CE/100 g ekstrak, ekstrak kloroform 10,9 ± 0,4 mg CE/100 g ekstrak, dan ekstrak n-heksan sejumlah 6,08 ± 0,4 mg CE/100 g ekstrak. Hasil penentuan kumarin total dapat dilihat bahwa kadar kumarin total tertinggi ada pada ekstrak metanol didukung dengan hasil identifikasi menggunakan metode KLT yang memperlihatkan noda kumarin yang terlihat jelas dibandingkan dengan ekstrak lainnya. Hal ini menunjukkan bahwa metanol adalah pelarut terbaik untuk mengekstrak kumarin pada buah api-api putih.
Algorithms for estimating the parameters of factorisation machines
Authors: Slabber Erika , Verster Tanja , de Jongh Riaan
Published: October 2022

Since the introduction of factorisation machines in 2010, it became a popular prediction technique amongst machine learners who applied the method with success in several data science challenges such as Kaggle or KDD Cup. Despite these successes, factorisation machines are not often considered as a modelling technique in business, partly because large companies prefer tried and tested software for model implementation. Popular modelling techniques for prediction problems, such as generalised linear models, neural networks, and classification and regression trees, have been implemented in commercial software such as SAS which is widely used by banks, insurance, pharmaceutical and telecommunication companies. To popularise the use of factorisation machines in business, we implement algorithms for fitting factorisation machines in SAS. These algorithms minimise two loss functions, namely the weighted sum of squared errors and the weighted sum of absolute deviations using coordinate descent and nonlinear programming procedures. Using a simulation study, the above-mentioned routines are tested in terms of accuracy and efficiency. The prediction power of factorisation machines is then illustrated by analysing two data sets. Keywords: Factorisation machines, Fitting algorithms, Parameter estimation
Overcoming State-Level Preemption to Electrify New Buildings: a Philadelphia Case Study
Authors: Gibbs Maura , Hsain Zakaria , Reagan Erin , Wolfman Shannon , Zaccarin Anne-Marie
Published: October 2022

The use of natural gas in heating and cooking negatively impacts environmental and human health. As government investments in clean energy production continue to increase, replacing natural gas appliances with electric alternatives is imperative to both reduce greenhouse gas emissions and protect public health. As a large US city with robust emissions reduction goals, Philadelphia, PA must significantly reduce natural gas use in buildings. However, many states, including PA, have advanced legislation that preemptively restricts municipalities from banning natural gas use. Using Philadelphia as a case study, we propose policy options, including electric appliance rebates, electrification incentives, and building efficiency standards, that US municipalities can pursue to circumvent state preemption laws in electrifying new construction, significantly reducing natural gas demand, and advancing their net-zero emissions goals.
Improving STEM Museum Accessibility in Pennsylvania for Diverse Communities
Authors: Weiss Amanda , Villiere Sophia
Published: October 2022

A baseline of scientific literacy among the general population is crucial for laypersons to be able to understand and evaluate data-driven recommendations for addressing public health and environmental crises. While updated formal education standards can help improve knowledge gaps for upcoming generations, they do not reach beyond K-12 students. Informal science, technology, engineering, and mathematics (STEM) public learning spaces, including museums, can potentially have broader impacts; however, the benefits are limited by accessibility. Notably, there is a lack of policy regarding sociocultural barriers that may exclude underrepresented communities from science museums. The Pennsylvania Historical and Museum Commission (PHMC) has demonstrated a willingness to support museum research and resource development throughout Pennsylvania (PA). However, resource availability alone does not guarantee the capability to meet the needs of disadvantaged groups in STEM learning spaces. Thus, there is a need for policy to establish standards to make science museums both more accessible and culturally aware to effectively serve their purposes of public learning and engagement. We recommend that the PHMC requires museums to form diversity and inclusion committees to collect and implement community input about museum content and establishes a requirement for exhibit information to be available in multiple languages to increase visitor diversity and improve public learning outcomes.
Dijitalleşmenin İş Sağlığı ve Güvenliğine Entegrasyonu ve Uygulanabilirliği
Authors: KAHRAMAN Zeyneb , YÜRÜTEN ÖZDEMİR Keriman
Published: October 2022

Tarih boyunca yaşanan teknolojik gelişmelere ayak uydurmaya çalışırken günlük yaşantımız da hızla değişmektedir. Bu değişim modern çağın en önemli ve yaşamın her alanını kapsayan bir dönüşümü olarak nitelendirilebilecek olan dijitalleşmedir. Özellikle Covid-19 pandemisi ile birlikte yaygınlık gösteren dijitalleşme, iş yaşamında iş sağlığı ve güvenliği (İSG) uygulamalarının dönüşümünü kaçınılmaz kılmakta ve İSG faaliyetlerinin dijitalleştirilmesi fırsatını zorunlu kılmaktadır. Endüstri 4.0 ile birlikte üretimin sürece uyum sağlamasıyla, iş sağlığı ve güvenliği kapsamında İSG 4.0 olarak nitelendirilen dijital İSG yöntemleri ortaya çıkmaktadır. Bu kapsamda performans iyileştirmesi, risklerin ve iş kazalarının azaltılmasına yönelik destekleyici faaliyetler ile iş yaşamına ilişkin çeşitli kısıtlamalarla beraber karşılaşılan zorluklar da azaltılmak istenmektedir. Bu bakımdan teknolojik gelişmelere uyumlu ve pratik olacak şekilde işyerindeki sağlık ve güvenliği sağlamak adına geliştirilen uygulamalar önem taşımaktadır. Bütün bunları göz önüne alınarak bu çalışma, literatürde yer alan çalışmalar taranarak derleme niteliğinde hazırlanmış olup, dijitalleşme ve beraberinde getirdiği yeni fırsatlara yönelik geliştirilen İSG alanındaki yenilikler, güncel çalışmalar ve yeni teknolojilerin iş sağlığı ve güvenliği alanındaki kullanım alanları hakkında bilgi vermek amacı ile hazırlanmıştır. Çalışmada, dijital yöntemlerin avantajları ile yaşanan gelişmelerin iş yaşamı üzerindeki etkilerine yer verilmiştir. Çalışma sonucunda dijital teknolojilerin İSG alanına entegrasyonu ile iş kazalarının yüksek oranda azaltılabileceği ancak yeni süreçlerle birlikte çalışanların yeni risklerle karşılaşılabileceği görülmüştür. Ayrıca dijitalleşmeye uyum sağlamada gizlilik ve güvenlik, netlik ve sorumluluk gibi konularda zorluklar yaşanacağı ve uygulanabilirliği konusundaki belirsizlikler nedeniyle çağın şartlarına uygun yaklaşımlar geliştirilmesi gerektiği sonucuna ulaşılmıştır.
CONFLICT IN THE PROCESS OF VALUE TRANSFORMATION
Authors: Anam Ahmad Misbahul
Published: October 2022

An inevitability of social life is the presence of conflict. Its appearance in the perspective of the harmony of a nation is seen as leaving only problems, but in the framework of societal change can actually be a stimulus of creativity. Every individual involved or the public who watches it, will be helped to choose which is positive and which is negative. That is, conflict can actually be seen as something positive for the birth of science or how to overcome it, even conflict is made to control changes in society.
DIMENSIONS AND STRATEGIES TO IMPROVE THE QUALITY OF EDUCATION AND ITS IMPACT ON THE DEVELOPMENT OF COMMUNITY HUMAN RESOURCES
Authors: Omayra Yudhita
Published: October 2022

Penelitian ini bertujuan untuk mengungkapkan kondisi umum pendidikan di Indonesia dan strategi yang telah dilakukan untuk meningkatkan kualitas pendidikan, serta dampaknya dalam pengembangan SDM masyarakat. Metodologi penelitian menggunakan kualitatif-kepustakaaan. Hasil penelitian dari penelitian ini ditemukan bahwa kualitas pendidikan di Indonesia saat ini belum bisa dibanggakan. Rendahnya daya saing pelajar Indonesia, munculnya pemasalahan internal dan eksternal dalam kehidupan bermasyarakat, menjadi indikator kuat bahwa SDM yang ada masih belum mampu berkontribusi secara maksimal untuk kemajuan bangsa. Mau tidak mau kita harus mengakui bahwa SDM seperti ini terlahir dari kualitas pendidikan yang masih rendah. Namun sebagai anak bangsa, tentunya kita harus optimis bahwa keadaan ini bisa kita perbaiki. Menyusun strategi untuk kepentingan tersebut adalah sesuatu yang urgent untuk kita ambil. Salah satu langkah yang dilakukan pemerintah dalam hal ini adalah dengan merancang konsep Renstra (Rencana Strategi) Kemendikbud 2020-2024. Renstra kemendikbud disusun sebagai acuan dalam pelaksanaan tugas kemendikbud yang merupakan penggerak sektor pembangunan dalam bidang pendidikan dan kebudayaan. Selanjutnya pelaksanaan berbagai strategi dan program yang sudah tercantum dalam Renstra ini membutuhkan peran aktif masyarakat untuk mensukseskannya. Melalui peran aktif masyarakat diharapkan hasil dari pelaksanaan Renstra ini mampu meningkatkan kualitas pendidikan di Indonesia, yang akhirnya mampu meningkatkan kualitas SDM masyarakat.
Notch1-Jagged1 Signaling Pathway in Oral Squamous Cell Carcinoma: Relation to Tumor Recurrence and Patient Survival
Authors: Elhendawy Heba A. , AL-Zaharani Nashwa , Ehab Ziad , Soliman Nahed , Ibrahiem Afaf T.
Published: October 2022

BACKGROUND: Dysregulated Jagged1/Notch1 signaling has been implicated in a variety of carcinomas, but little is known about the expression and possible role of Jagged1 and Notch1 in patients with oral squamous cell carcinoma (OSCC).

AIM: We set out to examine the clinical significance of Notch1 and Jagged1 expression in OSCC.

METHODS: Specimens were obtained from 44 patients who underwent surgical resection of primary OSCC. Immunostaining was done for Notch1 and Jagged1. The utilized markers’ expressions were analyzed in respect to 3 years overall survival (OS) and disease-free survival (DFS).

RESULTS: Poor prognosis was significantly associated with high Notch1 expression, high Jagged1 expression, advanced TNM clinical stage (III and IV), presence of distant metastasis, presence of nodal involvement, large-sized tumors (≥4 cm), presence of lymphovascular invasion, higher grade carcinomas, high Notch1 and Jagged1 coexpression, and carcinomas aroused from tongue and palate. Notch1, Jagged1, histologic grade, and tumor site were the independent predictors of DFS, while Jagged1 expression, histologic grade, and tumor site were the independent predictors of 3 years OS.

CONCLUSION: Our findings imply that either high levels of Notch1 or Jagged1 expression, or combined combination of both are related with poor prognostic outcomes.
The Impact of Early Levothyroxine Replacement in Subclinical Hypothyroidism on Glycemic Control Parameters and Quality of Life in Adult Patients
Authors: Mowafy Maha , Rushdy Eman Ahmed , Rakha Maha , Elshekheiby Eman , Soliman Saeed
Published: October 2022

BACKGROUND: Subclinical hypothyroidism is diagnosed by increased level of serum thyroid-stimulating hormone (TSH) with normal levels of free triiodothyronine (FT3) and free thyroxine (FT4). Controversy exists concerning the early treatment of subclinical hypothyroidism with levothyroxine when TSH level is below 10 mIU/L.

AIM: This stud aims to quantify the effects of a 3-month trial of levothyroxine replacement on quality of life in SCH patients with TSH level less than 10 mIU/L as primary outcome and fasting blood sugar and HbA1C levels as secondary outcome.

METHODS: This was a randomized controlled trial. It was carried out on subjects between 18 and 65 years, of both sexes attending the family medicine outpatient clinic at Cairo University Hospitals with untreated symptomatic mild subclinical hypothyroidism. Simple randomization was performed by assigning random numbers from random number table. Quality of life (Short-Form 36 Questionnaire) as well as fasting blood sugar levels and HbA1C were assessed before the replacement of levothyroxine and 3 months after starting treatment in the subclinical hypothyroidism patients (intervention group) and were compared to the control group.

RESULTS: The median of role limitations due to emotional problems, social functioning, and health change was higher in the intervention group in comparison with the control group. Moreover, the median scores of all general health questionnaire items showed significant positive statistical changes in the intervention group. There was also a significant improvement in glycemic control reflected in lower HbA1C levels and FBS.

CONCLUSION: The results of our study highlight the positive effect of early substitution with levothyroxine in subclinical hypothyroid patients regarding the quality of life and glycemic control in Egypt and support the argument for replacement.
Threats to UK freshwaters under climate change: Commonly traded aquatic ornamental species and their potential pathogens and parasites
Authors: Guilder James , Copp Gordon H. , Thrush Mark A. , Stinton Nicholas , Murphy Debbie , Murray Joanna , Tidbury Hannah J.
Published: October 2022

The aquatic ornamental industry, whilst providing socio-economic benefits, is a known introduction pathway for non-native species, which if invasive, can cause direct impacts to native species and ecosystems and also drive disease emergence by extending the geographic range of associated parasites and pathogens and by facilitating host-switching, spillover and spill-back. Although current UK temperatures are typically below those necessary for the survival and establishment of commonly-traded tropical, and some sub-tropical, non-native ornamental species, the higher water temperatures predicted under climate-change scenarios are likely to increase the probability of survival and establishment. Our study aimed primarily to identify which of the commonly-traded non-native ornamental aquatic species (fish and invertebrates), and their pathogens and parasites, are likely to benefit in terms of survival and establishment in UK waters under predicted future climate conditions. Out of 233 ornamental species identified as traded in the UK, 24 were screened, via literature search, for potential parasites and pathogens (PPPs) due to their increased risk of survival and establishment under climate change. We found a total of 155 PPPs, the majority of which were platyhelminths, viruses and bacteria. While many of the identified PPPs were already known to occur in UK waters, PPPs currently absent from UK waters and with zoonotic potential were also identified. Results are discussed in the context of understanding potential impact, in addition to provision of evidence to inform risk assessment and mitigation approaches.
Consistency in impact assessments of invasive species is generally high and depends on protocols and impact types
Authors: Bernardo-Madrid Rubén , González-Moreno Pablo , Gallardo Belinda , Bacher Sven , Vilà Montserrat
Published: October 2022

Impact assessments can help prioritising limited resources for invasive species management. However, their usefulness to provide information for decision-making depends on their repeatability, i.e. the consistency of the estimated impact. Previous studies have provided important insights into the consistency of final scores and rankings. However, due to the criteria to summarise protocol responses into one value (e.g. maximum score observed) or to categorise those final scores into prioritisation levels, the real consistency at the answer level remains poorly understood. Here, we fill this gap by quantifying and comparing the consistency in the scores of protocol questions with inter-rater reliability metrics. We provide an overview of impact assessment consistency and the factors altering it, by evaluating 1,742 impact assessments of 60 terrestrial, freshwater and marine vertebrates, invertebrates and plants conducted with seven protocols applied in Europe (EICAT; EPPO; EPPO prioritisation; GABLIS; GB; GISS; and Harmonia+). Assessments include questions about diverse impact types: environment, biodiversity, native species interactions, hybridisation, economic losses and human health. Overall, the great majority of assessments (67%) showed high consistency; only a small minority (13%) presented low consistency. Consistency of responses did not depend on species identity or the amount of information on their impacts, but partly depended on the impact type evaluated and the protocol used, probably due to linguistic uncertainties (pseudo-R2 = 0.11 and 0.10, respectively). Consistency of responses was highest for questions on ecosystem and human health impacts and lowest for questions regarding biological interactions amongst alien and native species. Regarding protocols, consistency was highest with Harmonia+ and GISS and lowest with EPPO. The presence of few, but very low, consistent assessments indicates that there is room for improvement in the repeatability of assessments. As no single factor explained largely the variance in consistency, low values can rely on multiple factors. We thus endorse previous studies calling for diverse and complementary actions, such as improving protocols and guidelines or consensus assessment to increase impact assessment repeatability. Nevertheless, we conclude that impact assessments were generally highly consistent and, therefore, useful in helping to prioritise resources against the continued relentless rise of invasive species.
Editorial
Authors: Giannetto Daniela , Piria Marina , Tarkan Ali Serhan , Zięba Grzegorz
Published: October 2022

not applicable
Virtual Laboratory-Based Game Application: The Quality and Its Effects Towards Students’ Motivation and Self-Regulated Learning
Authors: Suyanta  , Wiludjeng Insih , Jumadi  , Astuti Sri Rejeki Dwi , Sari Anggi Ristiyana Puspita , Md Isa Ilyas , Jafaar Rosly , Rahadian
Published: October 2022

Considering that students have a lot of experiences using mobile applications in their daily life, teacher should engage mobile application as learning media, thus the student are more motivated to learn independently. As a consequence, the teachers should implement existing mobile learning in the learning process and it is even better if they can develop it themselves. Besides, developing mobile learning is being heavy burden for a teacher as they still lack of skills to design and to develop mobile learning. Therefore, we aimed to explore the quality of Amazing Science application as mobile learning incorporated with a virtual laboratory based game application and to investigate its effect on students’ motivation and self-regulated learning. This research involved 5 sciences teachers and 50 students from five secondary schools in Yogyakarta, Indonesia. The research data were collected through online questionnaires consisting of three instruments, namely; viz product quality questionnaire for product validation, motivation questionnaires and self-regulated questionnaires for product implementation. Product validation data are quality data in the form of categories, so they are converted to data score using the Likert scale. Meanwhile, implementation data consisting of motivation and self-regulated learning data were analyzed with a sample paired t-test to discover the effect of product implementation towards motivation and self-regulated learning. The result revealed that Amazing Science application has a good quality according to the reviewers and students through a preliminary test and limited trial. Moreover, there are significant differences in both students’ motivation and self-regulated learning before and after the implementation of Amazing Science. However, there is no significant correlation between students’ motivation and self-regulated learning. From the findings, it can suggest that Amazing Science should be implemented by combining with the cooperative learning model, so others' skills can be improved. Besides, it can rebuild on another learning material or subject