bluuebunny/crossref_metadata_2025 huggingface dataset:
Fragmentation pattern of certain isatin–indole antiproliferative conjugates with application to identify their in vitro metabolic profiles in rat liver microsomes by liquid chromatography tandem mass spectrometry
Authors: Almutairi Maha S. , Kadi Adnan A. , Al-Wabli Reem I. , Attwa Mohamed W. , Attia Mohamed I.
Published: June 2020

The fragmentation pattern of certain isatin-based compounds was carried out using collision-induced dissociation inside the triple quadrupole mass analyzer. These data were used as a clue for the identification of metabolites of the recently reported isatin-based antiproliferative agent, namely, N′-[5-bromo-1-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-5-methoxy-1H-indole-2-carbohydrazide (1) in rat liver microsomes (RLMs) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Prediction of the vulnerable sites for metabolic pathways in compound 1 was performed by WhichP450 module of StarDrop software. In vitro metabolites for compound 1 were identified with the aid of rat liver microsomes. The in silico data were utilized as a guide for the practical work. Compound 1 was metabolized into three (hydroxylated, reduced and O-demethylated) metabolites in RLMs in the presence of NADPH. The chemical structures of those metabolites were elucidated, and the metabolic pathways were proposed by comparing the fragmentation pattern of the isatin–indole conjugates 1–7. The data presented in this paper provided useful information on the effect of different substituents on the ionization/fragmentation processes and can be used in the characterization of isatin derivatives. In silico toxicity assessments for the title compounds 1–7 and for the metabolites of compound 1 were conducted utilizing the deductive estimation of risk from existing knowledge (DEREK) module of StarDrop software.
Reaction characteristics of polymer expansive jet impact on explosive reactive armour
Authors: Yi Jianya , Wang Zhijun , Yin Jianping , Zhang Zhimin
Published: June 2020

In this study, a new damage mode for the explosive reactive armour (ERA) of a shaped charge jet was proposed. The response characteristics of polytetrafluoroethylene (PTFE) and polyamide (PA) polymer jet impact on the ERA were analysed. The expansion degree and the diameter of the PTFE jet are larger than those of the PA jet, but the compactness of the PTFE jet head is lower than that of the PA jet, resulting in different impact pressures of the different polymer expansive jets on the target. The PTFE jet achieved the penetration without initiation of the ERA at different standoffs, while the PA jet directly detonated the sandwich charge when impacting the ERA vertically and failed to penetrate the front plate when impacting the ERA at 68°. With the increase of standoff, the reaction degree of the PTFE jet to the ERA decreased gradually, and the aperture of the front plate did not change.
Coerced Human Mobility and Elite Social Networks in Early Dynastic Iraq and Iran
Authors: Bartash Vitali
Published: June 2020

The article provides a historical analysis of cuneiform records concerning the circulation of unfree humans among the political-cultic elite in southern Mesopotamia and the Persian Gulf during the Early Dynastic IIIb period, ca. 2475–2300 BCE. The analysis of the written data from the Adab city-state demonstrates that the royal house used the unfree as gifts to maintain a sociopolitical network on three spatial levels – the internal, local, and (inter)regional. The gift-givers and gift-receivers were mostly male adult members of the local and foreign elite, whereas the dislocated unfree humans were heterogeneous in terms of age, gender, and the ways they lost their freedom. The author relates the social profiles of both groups to the logistics of human traffic to reveal the link between social status and forms and nature of spatial mobility in the politically and socially unstable Early Dynastic Near East.
Werte in Betrieb?
Authors: Steinberg Swen
Published: June 2020

The article focuses on the connection between individual Christian religiosity, the patriarchal derivations for ideas of corporate order and the reaction to the labour or sales market using the example of the Saxon-Protestant pulp and paper enterprise Kübler & Niethammer. It shows that in late 19th and early 20th century, religion could be understood in a functional way in entrepreneurial contexts and therefore used flexibly: religious practices formulated as expectations by Christian entrepreneurs could develop into negotiating spaces between the workforce and the market. The latter is analysed in more detail using the example of work on Sundays. At the same time, this article points to the potential of studying industrialised rural regions, in which the connection between religion, business and the market still played a role in the first half of the 20th century – and probably beyond.
Characterizing overstretched NTRU attacks
Authors: De Micheli Gabrielle , Heninger Nadia , Shani Barak
Published: June 2020

Overstretched NTRU is a variant of NTRU with a large modulus. Recent lattice subfield and subring attacks have broken suggested parameters for several schemes. There are a number of conflicting claims in the literature over which attack has the best performance. These claims are typically based on experiments more than analysis. In this paper, we argue that comparisons should focus on the lattice dimension used in the attack. We give evidence, both analytically and experimentally, that the subring attack finds shorter vectors and thus is expected to succeed with a smaller dimension lattice than the subfield attack for the same problem parameters, and also to succeed with a smaller modulus when the lattice dimension is fixed.
A subexponential-time, polynomial quantum space algorithm for inverting the CM group action
Authors: Jao David , LeGrow Jason , Leonardi Christopher , Ruiz-Lopez Luis
Published: June 2020

We present a quantum algorithm which computes group action inverses of the complex multiplication group action on isogenous ordinary elliptic curves, using subexponential time, but only polynomial quantum space. One application of this algorithm is that it can be used to find the private key from the public key in the isogeny-based CRS and CSIDH cryptosystems. Prior claims by Childs, Jao, and Soukharev of such a polynomial quantum space algorithm for this problem are false; our algorithm (along with contemporaneous, independent work by Biasse, Iezzi, and Jacobson) is the first such result.
Identification of four genes associated with cutaneous metastatic melanoma
Authors: Ji Chen , Li Yuming , Yang Kai , Gao Yanwei , Sha Yan , Xiao Dong , Liang Xiaohong , Cheng Zhongqin
Published: June 2020

Background

Cutaneous melanoma is an aggressive cancer with increasing incidence and mortality rates worldwide. Metastasis is one of the primary elements that influence the prognosis of patients with cutaneous melanoma. This study aims to clarify the potential mechanism underlying the low survival rate of metastatic melanoma and to search for novel target genes to improve the survival rate of patients with metastatic tumors.

Methods

Gene expression dataset and clinical data were downloaded from The Cancer Genome Atlas portal. Differentially expressed genes (DEGs) were identified, and their functions were studied through gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. Survival and multivariate Cox regression analyses were used to screen out candidate genes that could affect the prognosis of patients with metastatic melanoma.

Results

After a series of comprehensive statistical analysis, 464 DEGs were identified between primary tumor tissues and metastatic tissues. Survival and multivariate Cox regression analyses revealed four vital genes, namely, POU2AF1, ITGAL, CXCR2P1, and MZB1, that affect the prognosis of patients with metastatic melanoma.

Conclusion

This study provides a new direction for studying the pathogenesis of metastatic melanoma. The genes related to cutaneous metastatic melanoma that affect the overall survival time of patients were identified.
From Moral Principles to Political Judgments: The Case for Pragmatic Idealism
Authors: Vandamme Pierre-Étienne
Published: June 2020

Political judgments usually combine a normative principle or intuition with an appreciation of empirical facts regarding the achievability of different options and their potential consequences. The interesting question dividing partisans of political idealism and realism is whether these kinds of considerations should be integrated into the normative principles themselves or considered apart. At first sight, if a theorist is concerned with guiding political judgments, non-ideal or realist theorizing (directly integrating such considerations) can seem more attractive. In this article, however, I argue that ideal theorizing might be considered valuable even by theorists moved by a pragmatic concern (guiding political judgments) because it is less exposed to conservatism. I nonetheless contend that the aim to guide action in the world as it is should not be abandoned. Therefore, I outline a four-step method for proceeding from abstract moral principles to concrete political judgments and apply it to a test case.
The crystal structure of 4a-formyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-1-2-6a,6b,9,9,12a-heptamethylpicen-10-yl acetate, C32H50O3
Authors: Latolla Nehemiah , Hosten Eric C. , Hlangothi Buyiswa G.
Published: June 2020

C32H50O3, orthorhombic, P212121 (no. 19), a = 8.0417(5) Å, b = 11.7996(6) Å, c = 30.1631(16) Å, V = 2862.1(3) Å3, Z = 4, R
gt(F) = 0.0712, wR
ref(F
2) = 0.2046, T = 296(2) K.
Integrated road traffic noise mapping in urban Indian context
Authors: Sonaviya Dipeshkumar R. , Tandel Bhaven N.
Published: June 2020

Road traffic noise has been recognized as a serious issue that affects the urban regions. Due to urbanization and industrialization, transportation in urban areas has increased. Traffic noise characteristics in cities belonging to a developing country like India are highly varied compared to developed nations because of its heterogeneous conditions. The objective of the research study is to assess noise pollution due to heterogeneous traffic conditions and the impact of horn honking due to un-authorized parked vehicles on the main roadside. Noise mapping has been done using the computer simulation model by taking various noise sources and noise propagation to the receiver point. Traffic volume, vehicular speed, noise levels, road geometry, un-authorized parking, and horn honking were measured on tier-II city roads in Surat, India. The study showed not so significant correlation between traffic volume, road geometry, vehicular speed and equivalent noise due to heterogeneous road traffic conditions. Further, analysis of traffic noise showed that horn honking due to un-authorized parked vehicles contributed an additional up to 11 dB (A), which is quite significant. The prediction models such as U.K’s CoRTN, U.S’s TNM, Germany’s RLS-90 and their modified versions have limited applicability for heterogeneity. Hence, the noise prediction models, which can be used for homogeneous road traffic conditions are not successfully applicable in heterogeneous road traffic conditions. In this research, a new horn honking correction factor is introduced with respect to unauthorized parked vehicles. The horn honking correction values can be integrated into noise model RLS-90, while assessing heterogeneous traffic conditions.
Les multiples facettes de la fonction d’enseignant-ressource
Authors: Coulombe-Godbout Maxime , Deslauriers Nathalie
Published: June 2020

Dès l'année 2006, l'école secondaire de l'Odyssée a mis en place des enseignants-ressources pour fournir une aide individualisée aux élèves jugés comme étant à risque. Après avoir constaté les bénéfices de ce service et les difficultés des enseignants-ressources pour faire face à la demande, la direction a modifié l'approche individuelle pour une formule basée sur des groupes de besoin, puis a opté pour le coenseignement. Mis à l'essai dans les classes de français et de mathématiques, le dispositif de coenseignement a apporté une grande satisfaction aux enseignants impliqués et a donné des résultats inespérés avec les élèves en difficulté.
Le dialogue cogénératif en contexte d’accompagnement au coenseignement en enseignement secondaire
Authors: Granger Nancy , Tremblay Philippe
Published: June 2020

Dans la pratique du coenseignement, la planification et la négociation entre coenseignants sont deux problématiques qui peuvent être surmontées par le dialogue cogénératif. Dans cet article, les cinq types de dialogues cogénératifs (de gestion, de remue-méninge, critique, directif et réflexif) sont exemplifiés par des extraits d’entretiens réalisés entre les coenseignants de trois écoles secondaires du Québec et les chercheurs qui les accompagnaient. L’objectif était de savoir comment le dialogue cogénératif s’opérationnalise chez les coenseignants et comment il peut servir à l’accompagnateur pour analyser les contenus de ces concertations pour la recherche et pour ensuite guider les coenseignants dans l’action.
Innover autour de la fonction d'enseignant-ressource: entre recherche, théorie et pratique
Authors: Granger Nancy , Tremblay Philippe , Maloney Philippe
Published: June 2020

Éditorial pour le volume 4 numéro 3
Nuevas propuestas para viejos desafíos: Desenmarañando el régimen de cambio climático
Authors: Chapagain Masís Rajesh
Published: June 2020

Debido al alcance global del cambio climático, las medidas o “curas” dirigidas a solucionar o “aliviar” el problema deben de ser acordadas e implementadas mediante la acción colectiva de los actores del sistema internacional, en especial los Estados, lo que lo hace un desafío para la gobernanza internacional. Con eseobjetivo, en las últimas décadas se ha desarrollado el régimen internacional de cambio climático, un proceso complejo y que sigue siendo un trabajo en progreso. En ese sentido, el estudio de las Relaciones Internacionales debe buscar la mejora en la comprensión del contexto político internacional que enmarcaese proceso y contribuye a la toma de decisiones efectivas (Underdal, 2017).
Tezės 1. World Colorectal CONFERENCE
Authors: Chirurgija Lietuvos
Published: June 2020

International Society of University Colon and Rectal Surgeons (ISUCRS)Interim meeting in Vilnius 2013World Colorectal C O N F E R E N C EMay 31 – June 1, 2013Vilnius, Lithuania
Rezultatų vertinimas po hallux valgus korekcijos Lapidus operacijos ir Z-osteotomijos metodais
Authors: Janavičius Julius , Kocius Manvilius
Published: June 2020

Įvadas / tikslasPalyginti komplikacijų skaičių bei ligonių pasitenkinimą turimais rezultatais po hallux valgus patologijos korekcijos Lapidus operacijos ir Z-osteotomijos metodais.Pacientai ir metodaiTirta 70 pacientų (amžiaus vidurkis 51,9 metų; 4 vyrai ir 66 moterys), kuriems VšĮ RVUL 2006–2008 metais operuota hallux valgus patologija atliekant Lapidus operaciją (L grupė) arba Z-osteotomiją (Z grupė). Visų pacientų kampas tarp pirmo ir antro padikaulio prieš operaciją buvo 16–23°. Rezultatai vertinti praėjus ne mažiau kaip dvejiems metams po operacijos. Apžiūros metu pacientai buvo klausiami apie atsiradusias komplikacijas, atliktas fizinis ištyrimas, matuota MTP1 sąnario judesių amplitudė, atlikta ir įvertinta operuotos pėdos rentgenograma. Pasitenkinimui įvertinti naudota vizualinė analogijų skalė (VAS).RezultataiIš viso tirtiems pacientams buvo išoperuota 80 pėdų (4 vyrų, 76 moterų). Atlikta po 40 (50 %) abiejų tipų operacijų. 61 % atveju po operacijos buvo bent viena komplikacija. Komplikacijų dažnumas nesiskyrė abejose grupėse (p>0,05). MTP1 artrozės išsivystymo atvejai abiejų grupių buvo panašūs (p>0,05). Nustatyta koreliacija tarp pacientų pasitenkinimo operacijos rezultatu ir komplikacijų skaičiaus, r=0,44 (p<0,05).IšvadosPacientų pasitenkinimas koreliuoja su komplikacijų skaičiumi. Komplikacijų pasiskirstymas ir pacientų pasitenkinimas po Lapidus operacijos ir Z-osteotomijos nesiskyrė. Vadinasi, šiais aspektais abu metodai lygiaverčiai.
Occult femoral neck fractures
Authors: Uvarovas Valentinas , Vaitiekus Andrius , Šatkauskas Igoris
Published: June 2020

Occult femoral neck fractures are becoming an urgent problem for aging population. In general the term “occult fracture” is used to denote fractures which are occult on plain radiographs, but found to be present on other imaging modalities or intra-operatively. Estimated incidence of occult femoral neck fracture is 2 to 10 per cent according to the literature. There is a risk of secondary fracture displacement, and other related complications in case of late diagnosis of these fractures. Timely diagnosis of these fractures in elderly patients improves treatment outcomes, reduces invalidity risk. The higher mortality rate is associated with well diagnosed femoral neck fractures whose treatment was delayed for reasons other than missing X-ray evidence of a fracture.
Ranka asistuojamoji laparoskopinė gaubtinės ir tiesiosios žarnos chirurgija: vieno centro 473 ligonių patirtis
Authors: Kuliešius Žygimantas , Dulskas Audrius , Kuliavas Justas , Rudinskaitė Giedrė , Samalavičius Narimantas E.
Published: June 2020

Įvadas / tikslas Ranka asistuojamoji laparoskopinė chirurgija (HALS) į klinikinę praktiką įdiegta jau beveik tris dešimtmečius. Ji jungia atviros chirurgijos ir laparoskopinės (minimaliai invazinės) chirurgijos būdus. Nepaisant paskelbtų duomenų, chirurgų bendruomenė vis dar skeptiškai žvelgia į šią hibridinę laparoskopijos formą. Straipsnio tikslas – apžvelgti vieno centro 10 metų patirtį taikant HALS metodiką.Metodai Tai retrospektyvioji duomenų analizė. Apžvelgti 473 pacientai, gydyti Nacionaliniame vėžio institute dėl kolorektalinės pato­logijos nuo 2006 m. sausio iki 2016 m. liepos mėn. Šie pacientai buvo operuoti HALS būdu.Rezultatai Pacientų amžiaus vidurkis buvo 64,14 ± 9,75 metai. Moterų – 240 (50,73 %), vyrų – 233 (49,27 %). Vidutinė hospitalizacijos tru­kmė buvo 6,92 dienos (nuo 2 iki 34 d.). Histologinio tyrimo duomenimis, vidutinis pašalintų limfmazgių skaičius 16,97 ± 12,10. I, II, III ir IV stadijų grupes sudarė atitinkamai 142 (30,02 %), 139 (29,35 %), 153 (32,35 %) ir 36 (7,61 %) pacientai. Trims pa­cientams patologija buvo gerybinė. Segmentinės kolektomijos atliktos 53 % pacientų, tiesiosios žarnos rezekcijos – 45,3 % pacientų, kitos operacijos sudarė 1,7 %. Pakartotinės intervencijos prireikė 10 pacientų (2,11 %). Komplikacijų dažnis buvo 6,55 %, 2 pacientai (0,42 %) mirė.Išvada HALS yra saugi ir efektyvi technika, kuri leidžia pasinaudoti visais laparoskopinės kolektomijos privalumais bei minimaliai invaziniu būdu gali būti pritaikyta sudėtingais klinikiniais atvejais.
Neįprastas tiesiosios žarnos vėžio metastazavimas: atvejo pristatymas
Authors: Kuliavas Justas , Dulskas Audrius , Drachneris Julius , Mišeikytė Kaubrienė Edita , Samalavičius Narimantas E.
Published: June 2020

Labai retai tiesiosios žarnos vėžio metastazės plinta į varpą. Literatūros duomenimis, tokių atvejų yra aprašyta mažiau kaip 40. Prognozė yra bloga ir išgyvenamumas trumpas. Tiesiosios žarnos vėžio metastazių plitimo į varpą mechanizmas nežinomas. Populiariausia teorija yra apie retrogradinį veninį plitimą. Aprašoma keletas gydymo metodų, tačiau nė vienas nėra pranašesnis. Autoriai pristato 41 metų amžiaus vyro klinikinį atvejį. Vyrui buvo diagnozuotas tiesiosios žarnos vėžys, prieš operaciją taikyta radioterapija, paskui operacinis gydymas ir pooperacinė chemoterapija. Nepaisant to, po dvejų metų išsivystė metastazės varpoje. Po metastazių diagnozės ligonis išgyveno du mėnesius.
Pirmoji patirtis implantuojant dirbtinį sfinkterį „AMS 800“
Authors: Černiauskienė Aušra , Valatka Paulius
Published: June 2020

TikslasPateikti pirmuosius vyrų šlapimo nelaikymo po radikalios prostatektomijos rezultatus, implantuojant „AMS 800“ dirbtinį sfinkterį. Įvertinti šio metodo efektyvumą ir pranašumą.Medžiaga ir metodai2016 m. lapkričio 4 d. VUL SK Urologijos centre 3 pacientams dėl sunkaus šlapimo nelaikymo, atsiradusio po radikalios prostatektomijos dėl prostatos karcinomos, buvo implantuoti šlapimo pūslės dirbtiniai sfinkteriai „AMS 800“. Šiems pacientams konservatyvus šlapimo nelaikymo gydymas buvo neveiksmingas. Visi pacientai prieš operaciją buvo išsamiai ištirti. Jiems prostatos vėžio progresavimo, šlaplės striktūrų, liekamojo šlapimo nebuvo, šlapimo takų infekcijos nerasta. Pacientai patikrinti praėjus mėnesiui po dirbtinio sfinkterio aktyvavimo.RezultataiIš viso buvo implantuoti 3 dirbtiniai sfinkteriai 3 pacientams. Praėjus 6 savaitėms buvo aktyvuoti 2 sfinkteriai, vieno sfinkterio aktyvuoti nepavyko dėl prietaiso techninių kliūčių, tačiau po 1 savaitės pakartotinis aktyvavimas buvo sėkmingas. Patikrinus 3 pacientus praėjus 1 mėnesiui po sfinkterio aktyvavimo, dviem visiškai nereikėjo įklotų, 1 šlapimo laikymas pagerėjo 60 proc. (anksčiau sunaudojo 6, dabar užtenka 2 įklotų).IšvadosRemdamiesi literatūra ir savo pirmuoju patyrimu galime teigti, kad „AMS 800“ dirbtinis sfinkteris yra laiko patikrintas ir laikomas auksiniu standartu gydant vidutinio ir didelio laipsnio įtampos šlapimo nelaikymą. Tinkamai ištyrus pacientą, pasiekiami geri gydymo ir paciento pasitenkinimo operacija rezultatai, labai pagerėja gyvenimo kokybė.
Reversible Acute Duodenitis as a Complication of Endoscopic Biliary Stenting
Authors: Tonolini Massimo
Published: June 2020

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The Contribution of Intrabolus Pressure to Symptoms Induced by Gastric Banding
Authors: Preissler Claudia , Krieger-Grübel Claudia , Borovicka Jan , Fried Michael , Tutuian Radu
Published: June 2020

Background & Aims: Mechanisms that ultimately lead to dysphagia are still not totally clear. Patients with laparoscopic gastric banding (LAGB) often complain about dysphagia, regurgitation and heartburn. Our aim was to evaluate the contribution of intrabolus pressure to symptoms of gastric banding.Methods: This study investigated 30 patients with LAGB before and 3 months after conversion to Roux-en-Y gastric bypass (RYGB), evaluating symptoms with a 7-point-Likert-scale and esophageal peristalsis, esophageal bolus transit and intrabolus pressure changes using combined impedance-manometry.Results: Conversion from LAGB to RYGB leads to a significant reduction in dysphagia (1.9 ± 0.4 vs. 0.0 ± 0.0; p< 0.01) and regurgitation (4.2 ± 0.4 vs. 0.1 ± 0.1; p< 0.01) symptom scores. For liquid swallows we found a modest but significant correlation between the intensity of dysphagia and intrabolus pressure (r=0.11; p<0.05) and the intensity of regurgitation and intrabolus pressure for viscous swallows (r=0.12, p<0.05) in patients with LAGB. There was a significant (p< 0.05) reduction in intrabolus pressure at 5 cm above LES before (liquid 10.6 ±1.0; viscous 13.5 ± 1.5) and after (liquid 6.4 ± 0.6; viscous 10.5 ± 0.9) conversion from LAGB to RYGB.Conclusion: Current data suggest that intraesophageal pressure during bolus presence in the distal esophagus contributes to the development but not to the intensity of dysphagia and regurgitation.
A Real Life Boceprevir Use in Treatment-Experienced HCV Genotype 1 Patients with Advanced Fibrosis
Authors: Gheorghe Liana , Iacob Speranta , Simionov Iulia , Caruntu Florin , Motoc Adriana , Arama Victoria , Preotescu Liliana , Stefan Ion , Goldis Adrian , Brisc Cristian , Rugina Sorin , Rednic Nicolae
Published: June 2020

Background: A number of high quality randomized clinical trials examining the efficacy and safety of triple therapy in genotype-1 HCV-infected patients have been published. However, these trials included a small number of patients with advanced fibrosis, and selected a population different from that in real-world settings.Aim: To determine the efficacy of boceprevir, pegInterferon and ribavirin regimen in genotype-1 treatment-experienced HCV-infected patients with cirrhosis and bridging fibrosis in real-life setting.Method: 167 treatment-experienced patients (85.6% relapsers) out of which 33.5% had cirrhosis, with a mean age of 52.6 years, registered in the Romanian Name Patient Program Database were included into the study.Results: 16.7% of patients had a viral load >100 IU/mL. Undetectable HCV RNA was encountered in 77.3% of patients at week 12. Multiple logistic regression analysis revealed the following independent predictors, measured at week 8, for an HCV RNA ≥100 IU/mL at week 12 of triple therapy: alanine aminotransferase values (p=0.01), hemoglobin level (p=0.04) and <2log drop of viral load (p<0.0001). A stopping score at 8 weeks was created as the sum of these 3 parameters, with a total of 4 possible points. AUROC of this score was 0.84, with a sensitivity of 75% and a specificity of 86.2%.Conclusion: Triple therapy in this cohort of real-life genotype-1 HCV-infected patients with advanced fibrosis showed robust early virological response (EVR) rates. A week 8 model predicting lack of EVR was created, with good clinical utility that can be validated in prospective larger cohorts.
Scientific Publications on Portal Vein Thrombosis and Budd- Chiari Syndrome: a Global Survey of the Literature
Authors: Qi Xingshun , Jia Jia , Ren Weirong , Yang Man , De Stefano Valerio , Wang Juan , Fan Daiming
Published: June 2020

Background & Aims: Portal vein thrombosis (PVT) and Budd-Chiari syndrome (BCS) are two rare vascular disorders of the liver that can lead to life-threatening complications. We conducted a global survey to systematically analyze the scientific publications in the fields of PVT and BCS.Methods: All papers regarding PVT and BCS were identified via the PubMed, EMBASE, and Cochrane library databases. The publication year, country, type of paper, study design, and number of citations were summarized. Good quality papers were defined as those in which a high proportion of homogeneous patients with BCS and/or PVT was observed.Results: We identified 6691 and 4325 papers regarding PVT and BCS, respectively. The number of papers gradually increased over time. Researchers from the USA published the greatest number of papers (PVT: n=1418; BCS: n=888). Clinical studies were the most common type of paper (PVT: n=5395; BCS n=3171), but fewer than half of these observed more than 10 patients (PVT: n=2667/5395; BCS: n=1092/3171). Furthermore, fewer than half of the clinical studies with more than 10 patients were of good quality (PVT: 976/2667; BCS: 466/1092). According to the study design, the good quality papers were classified as cohort studies (PVT: n=865; BCS: n=421), case-control studies (PVT: n=98; BCS: n=45), and randomized controlled trials (PVT: n=13; BCS: n=0). The 5 most frequently cited original articles and guidelines/consensuses were also listed.Conclusions: Despite an increase in the number of papers regarding PVT and BCS over time, most of the papers had a small sample size, suggesting the necessity of large cohort studies or randomized controlled trials.
Recreational Drugs: a New Health Hazard for Patients with Concomitant Chronic Liver Diseases
Authors: Tarantino Giovanni , Citro Vincenzo , Finelli Carmine
Published: June 2020

Our purpose in this article is to review the effects of recreational drugs, used either on their own but principally combined with alcohol consumption, in determining hepatic injury or influencing the evolution of some chronic diseases of the liver, specifically HCV infection and NAFLD. A deleterious role of daily use of recreational drugs, in particularly cannabis, has been shown to demonstrate clearly a rapid progression of fibrosis and steatosis, leading to a major severity in patients with chronic hepatitis C. On the other hand, the effects of the misuse of these substances on NAFLD, the main obesity-related comorbidity, leading to addiction, is still to be elucidated even though some clues to the recreational drugs hepatotoxicity  are  already present in the literature. This short review aims at raising awareness about this topic.
Benefits of Curing Hepatitis C Infection
Authors: Marinho Rui T. , Vitor Sofa , Velosa José
Published: June 2020

The hepatitis C virus (HCV) infection is one of the most important chronic viral infections worldwide and affects 3% of the world population, approximately 170-200 million people. The consequences of chronic infection are liver cirrhosis and hepatocellular carcinoma, which develop in 20-30% of the patients, leading to hepatic failure, need for liver transplantation and death. The hepatitis C virus is a RNA virus that is prevalent worldwide and is classified by the World Health Organization (International Agency for Research on Cancer) as one of the six oncogenic viruses. Hepatocellular carcinoma is one of the most important cancers and is fifth worldwide, but third in men in terms of mortality. Hepatitis C kills approximately 350,000 people every year, surpassing HIV infection in many countries as a cause of death.Hepatitis C virus can kill in different ways: it can cause cirrhosis, cancer or severe liver disease in people co-infected with HIV. Hepatitis C treatment started in the mid 1980s with a 6% efficacy rate among patients taking thrice-weekly injections of human interferon. This therapy had numerous side effects. The efficacy of hepatitis C treatment has increased, and currently, the efficacy of the so-called direct antiviral agents (DAAs) is 80-90%. The benefits of a cure are enormous and include a lifetime negative serum HCV RNA, disappearance of HCV in the liver, regression of cirrhosis, decreased risk of developing hepatocellular carcinoma, disappearance of oesophageal varices, no more risk of HCV transmission to sexual partners or children, and increased survival.At present, hepatitis C can be considered a curable disease.
Is there a role for chromoendoscopy in the diagnosis of coeliac disease?
Authors: Johnston Alexander J. , Kurien Matthew , Avgerinos Anastasios , Mooney Peter D. , Sanders David S.
Published: June 2020

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Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial
Authors: Perkins Rebecca B. , Legler Aaron , Jansen Emily , Bernstein Judith , Pierre-Joseph Natalie , Eun Terresa J. , Biancarelli Dea L. , Schuch Thomas J. , Leschly Karin , Fenton Anny T.H.R. , Adams William G. , Clark Jack A. , Drainoni Mari-Lynn , Hanchate Amresh
Published: June 2020

OBJECTIVES:

To evaluate the effectiveness of a stepped-wedge randomized trial of Development of Systems and Education for Human Papillomavirus Vaccination (DOSE HPV), a multilevel intervention.

METHODS:

DOSE HPV is a 7-session program that includes interprofessional provider education, communication training, data feedback, and tailored systems change. Five primary care pediatric and/or family medicine practices completed interventions between 2016 and 2018; all chose to initiate vaccination at ages 9 to 10. We compared vaccination rates in the preintervention, intervention, and postintervention periods among 9- to 17-year-olds using random-effects generalized linear regression models appropriate for stepped-wedge design, accounting for calendar time and clustering of patients by providers and clinic. Outcomes included (1) the likelihood that eligible patients would receive vaccination during clinic visits; (2) the likelihood that adolescents would complete the series by age 13; and (3) the cumulative effect on population-level vaccine initiation and completion rates. Postintervention periods ranged from 6 to 18 months.

RESULTS:

In the intervention and postintervention periods, the adjusted likelihood of vaccination at an eligible visit increased by >10 percentage points for ages 9 to 10 and 11 to 12, and completion of the vaccine series by age 13 increased by 4 percentage points (P < .001 for all comparisons). Population-level vaccine initiation coverage increased from 75% (preintervention) to 84% (intervention) to 90% (postintervention), and completion increased from 60% (preintervention) to 63% (intervention) to 69% (postintervention).

CONCLUSIONS:

Multilevel interventions that include provider education, data feedback, tailored systems changes, and early initiation of the human papillomavirus vaccine series may improve vaccine series initiation and completion beyond the conclusion of the intervention period.
Telemedicine, Artificial Intelligence and Humanisation of Clinical Pathways in Heart Failure Management: Back to the Future and Beyond
Authors: D’Amario Domenico , Canonico Francesco , Rodolico Daniele , Borovac Josip A , Vergallo Rocco , Montone Rocco Antonio , Galli Mattia , Migliaro Stefano , Restivo Attilio , Massetti Massimo , Crea Filippo
Published: June 2020

New technologies have been recently introduced to improve the monitoring of patients with chronic syndromes such as heart failure. Devices can now be employed to gather large amounts of data and data processing through artificial intelligence techniques may improve heart failure management and reduce costs. The analysis of large datasets using an artificial intelligence technique is leading to a paradigm shift in the era of precision medicine. However, the assessment of clinical safety and the evaluation of the potential benefits is still a matter of debate. In this article, the authors aim to focus on the development of these new tools and to draw the attention to their transition in daily clinical practice.
New Pampas cat Leopardus colocolo (Molina, 1782) (Mammalia: Carnivora: Felidae) records for the Chaco ecoregion raise questions on the distribution and population status of this felid in Argentina
Authors: Nanni Ana Sofía , Castro Lucila , Cuyckens Griet An Erica , Barri Fernando R. , Giordano Anthony J. , Lucherini Mauro
Published: June 2020

The Pampas cat is a poorly-known small felid distributed throughout a large portion of South America, reported as extinct in the Pampas of Argentina, and absent from a large portion of the Argentine Dry Chaco. Here, we compile data from the field and collections to report new presence records of the Pampas cat from the Dry Chaco of Argentina, which update to the distribution of this felid in the region.  We discuss the need of further assessments for the species distribution in the light of ongoing land-use changes in the area.
Impact of increasing atmospheric CO2 concentration on growth characteristics and yield in maize and rice
Authors: Xie X. J. , Li R.Y. , Huang L.D. , Bao Y.X.
Published: June 2020

To assess the effect of increasing atmospheric CO2 concentration ([CO2]) on growth and yield in maize and rice, an experiment was carried out in open top chambers (OTCs) at different atmospheric CO2 concentration treatments (550 ?mol/mol, T1; 750 ?mol/mol, T2 and a control, CK) in Nanjing, Jiangsu, China. Our results indicated that the plant height, leaf area index (LAI), Soil and Plant Analyzer Development (SPAD) and net photosynthesis (NPn) of the maize (Zhengdan 958) and rice (Huaidao 5) at three development stages under the increasing [CO2] followed the order of CK <T1<T2. The growth indexes of two crop cultivars showed no significant differences nor did they show significant differences at certain development stages among the three CO2 treatments. The growth durations of maize and rice were delayed due to the elevated [CO2] treatments individually, but the impact before jointing was slightly greater than that after jointing. The above-ground biomass in maize was increased by 6.70–10.10%, and the above-ground biomass in rice was increased by 8.98–13.74% (P < 0.05) under the elevated [CO2] treatments. Maize yields were increased by 5.26% and 11.45%, and rice yields were increased by 19.76% and 24.43% under the T1 and T2 treatments. Other yield components of two crop cultivars were enhanced accordingly under high [CO2] treatments. The kernels per spike and crop yield showed significant differences between two high [CO2] plots and CK (P < 0.05). However, there were no significant differences for other yield components (P > 0.05).
“O outro” na academia: o anseio pela descolonização das ciências das religiões em relação à atuação feminina
Authors: Farias Alana Carla Lucena
Published: June 2020

Ao longo dos anos, a área das Ciências das Religiões foi sendo construída até se tornar uma disciplina autônoma. Nesse processo, diversos nomes foram destacados enquanto pilares teóricos e metodológicos da disciplina, porém, essas referências foram traçadas seguindo um padrão colonial. Desse modo, com o intuito de expandir os horizontes, epistemologias pós-coloniais são propostas por vários pesquisadores para construir um pensamento contra-hegemônimo que abale as relações práticas de poder que envolvem um viés étnico, racial e de gênero. Fazendo um paralelo com gênero, epistemologias feministas têm utilizado uma hermenêutica da suspeição para questionar a dominância masculina na área. Tais abordagens podem contribuir para impulsionar um estudo das religiões mais igualitário e essas discussões são essenciais na atualidade.
Empoderamento e feminismo negro: decolonizando epistemologias e mentalidades
Authors: Berth Joice , Pinheiro dos Santos Naira , Menezes Nilza , Kikuchi Campanaro Priscila
Published: June 2020

Joice Berth Entrevista por Naira Pinheiro dos Santos, Nilza Menezes e Priscila Kikuchi Campanaro
"Eu Dommenique": O FemDom no BDSM e suas implicações para as performances de gênero e para o discurso médico-religioso
Authors: Campelo Ferreira Geise
Published: June 2020

Este artigo visa discutir subversões dos papéis tradicionais de gênero, encontradas em relações BDSM do tipo FemDom, a partir do livro “Eu, Dommenique”, da Dominatrix Profissional Dommenique Luxor. Objetiva-se compreender as dinâmicas subversivas que essas relações permitem às mulheres, que ocupam o papel dominante, e aos homens, que ocupam o papel submisso, analisando algumas práticas que aparecem na narrativa, a saber: Humilhação, Feminização e Inversão. A categoria de análise Gênero será usada para problematizar estas práticas e os papéis socialmente delimitados para homens e mulheres dentro e fora da Comunidade BDSM, juntamente com a proposta de uma Teologia Indecente de Marcella Althaus-Reid para a análise da sexualidade expressa de forma singular nas vivências sadomasoquistas e seus jogos de poder.
Konsep Jarak Terdekat dalam Menghadap Kiblat
Authors: Qulub Siti Tatmainul
Published: June 2020

Menghadap Kiblat adalah persyaratan yang sah dalam sholat. Dalam beberapa literatur astronomi baru-baru ini disebutkan bahwa makna arah kiblat adalah jarak terdekat dengan Ka'bah. Dalam buku-buku literatur fiqh dan juga astronomi klasik tidak disebutkan arti arah kiblat sebagai jarak terdekat dengan Ka'bah (Mekkah). Kata kiblat dalam ayat tentang ini berarti "shatrah" dan "jihah" dimana keduanya memiliki nuansa menghadap ke arahnya, tanpa menunjukkan apakah arah yang terdekat atau terjauh. Makalah ini mengeksplorasi konsep makna jarak terdekat dalam menentukan arah menghadap kiblat. Artinya pencarian mulai dari arah kiblat yang didominasi oleh fuqohaâ€™ diikuti dengan makna menghadap arah kiblat oleh astronom pada zaman Nabi sampai astronom hari ini. Dalam pencarian itu akan dicari sejak saat muncul istilah arah kiblat sebagai jarak terdekat dan siapa di dalam komunitas ilmiah tersebut.
Penyederhanaan dan Penyempurnaan Sistem Pemilu di Indonesia
Authors: Yasin Ikhsan fatah
Published: June 2020

Permasalahan pemerintahan presidensil dengan multi partai di Indonesia masih menjadi pekerjaan rumah yang tak kunjung selesai hingga kini, banyak para pakar politik dan HTN yang menyimpulkan tidak efektifnya system presidensiil dalam model multi partai. Di sisi lain, Konstitusi kita telah menegaskan melalui ciri-cirinya, bahwa Indonesia menganut sistem pemerintahan presidensial, akan tetapi diterapkan dalam konstruksi politik multipartai. Semenjak awal diadakanya pemilihan umum, Indonesia masih tetap menggunakan system proporsional dengan berbagai tambahan warna distrik. Karena tidak berhasilnya proporsional yang telah digunakan semenjak pemilu pertama, mungkin perlu mencoba hal yang baru yakni menggunakan system distrik dengan berbagai variasi agar tidak terlalu mencederai demokrasi. Model parliamentary threshold dan pengetatan syarat bagi partai untuk mengikuti pemilu memang sedikit demi sedikit akan menyederhanakan partai. Meskipun begitu standar tinggi parliamentary threshold justru menimbulkan banyak kecaman, partai yang kecil merasa dizalimi dan mengatakan hal ini bertentangan dengan demokrasi.
Rekontruksi Akibat Hukum atas Sikap Nabi saw. yang Meninggalkan Suatu Amalan Tertentu (Tark al-Nabi)
Authors: Huda Bakhrul
Published: June 2020

Differences in punishing something happen among Muslim scholars. This is not only because of the way of view in terms of dalalah al-lafd -to understand the meaning contained in the word-, but the factor has not reached nass by the others or the other's way of view thatâ€™s the nass is invalid, also because of the problem of tark al-nabi -the attitude of the Prophet pbuh. which leaves doing something-is a vast field that also greatly supports the differences between moslems. This Terma of al-tark is one of the ways we understand and act on legal differences among Muslims. The author is interested in studying this term by library so that the results of this study could be one additional reading reference in drawing the conclusions of phenomena that occur today especially since there is a conservative dakwah disturbing spread in many social media. So we will know that the Prophetâ€™s attitude of not doing in some cases not necessarily haram or even makhruh either in the realm of worship or culture if not supported with the other theorems.
Peralihan Hak Atas Tanah bagi Pegawai Negeri yang Ingin Memiliki Rumah Dinas dari Pemerintah
Authors: Bikan Parmono
Published: June 2020

Dalam rangka meningkatkan kesejahteraan pegawai negeri, Pemerintah mengadakan perumahan dinas, yang di antaranya bisa dimiliki dengan secara sewa beli. Pembayarannya melalui pemotongan gaji pegawai negeri tersebut setiap bulannya, dan dibuat perjanjian sewa beli di hadapan Notaris. Setelah habis jangka waktu sewa beli maka dikeluarkan Surat Pelepasan Hak dari pemerintah yang dibuat di hadapan Notaris kepada pegawai negeri tersebut. Kesimpulan dari penulisan ini adalah: pertama, autentisitas akta jual beli atas tanah pemerintah yang dibeli oleh Pegawai Negeri adalah sah dan mempunyai kekuatan pembuktian yang sempurna, namun dalam hal untuk pengurusan pemberian hak milik di Kantor Pertanahan, maka akta jual beli tersebut tidak dapat dipergunakan sebagai persyaratannya, melainkan Akta atau Surat Pelepasan Hak dari pemerintah yang dibuat di hadapan Notaris. Kedua, bentuk perlindungan hukum bagi Pegawai Negeri yang membeli rumah Negara untuk tempat tinggal adalah berupa pengaturan melalui peraturan perundang-undangan, yang terdiri atas pengaturan mengenai tata cara pemberian hak milik terhadap pegawai negeri atau ahli warisnya atas rumah dinas yang dibelinya.
Kekuatan Pembuktian Akta Notaris yang Mengandung Kesalahan dalam Penulisan Komparisi
Authors: Budiawan Budiawan
Published: June 2020

Perbaikan kesalahan penulisan "komparisi" harus sesuai dengan prosedur pada ketentuan yang berlaku di dalam perundang-undangan, karena pada dasarnya apa yang tertuang di dalam akta otentik haruslah benar, agar kekuatan Akta otentik sebagai alat bukti dapat dipertahankan. Ini merupakan tugas Notaris, dikarenakan dia harus menjamin bahwa dokumen dari para penghadap seperti identitas beserta bukti-bukti yang ada adalah benar. Akhir dari tulisan ini menyimpulkan bahwa (1) penulisan komparisi akta yang tidak sesuai dengan syarat ketentuan yang diberlakukan oleh hukum yang mengatur masuk dalam kategori suatu pelanggaran, dan (2) tanggung gugat notaris secara perdata atas akta yang dibuatnya, dalam hal ini adalah tanggung jawab terhadap kebenaran materiil akta, dalam konstruksi perbuatan melawan hukum, sehingga apabila dari kesalahan tersebut terjadi kerugian materil atau inmateril maka notaris wajib untuk memperbaiki atau mengganti kerugiian tersebut.
Batasan Rumah Susun yang Dijadikan Agunan pada Bank
Authors: Bahrudin Rizal
Published: June 2020

Tujuan dari penulisan ini adalah mengetahui eksistensi dan kekuatan eksekutorial sertipikat hak tanggungan terhadap hak milik atas satuan rumah susun sebagai jaminan hutang dalam perjanjian kredit di Bank. Undang-Undang Rumah Susun telah menjadi objek agunan/jaminan yang dapat dibebani dengan oleh Undang-Undang Hak Tanggungan, dan hanya dapat dikenakan pada Hak Milik atas Satuan Rumah Susun karena merupakan kepemilikan seseorang yang merupakan benda-benda yang berdiri sendiri. Tujuan dari penulisan ini adalah mengetahui eksistensi dan kekuatan eksekutorial sertipikat hak tanggungan terhadap hak milik atas satuan rumah susun sebagai jaminan hutang dalam perjanjian kredit di Bank. Landasan hukum eksekusi Hak tanggungan atas satuan rumah susun terdapat dalam Pasal 20 UUHT, dimana objek hak tanggungan dijual melalui pelelangan umum menurut cara yang ditentukan dalam peraturan perundang-undangan yang berlaku dan pemegang Sertipikat Hak tanggungan berhak mengambil seluruh atau sebagian dari hasilnya untuk pelunasan piutangnya, dengan hak yang mendahului dari pada kreditur-kreditur yang lain. Hasil dari penulisan ini adalah dalam menjalankan prinsip kehati-hatian, Bank tidak akan berani memberikan pinjaman atau kredit kepada masyarakat tanpa adanya jaminan. Hak milik atas Satuan Rumah Susun dapat dijadikan objek jaminan kredit dan diikat dengan Hak Tanggungan.
Kekuatan Hukum Akta Jual Beli Tanah yang Dibuat PPAT (Studi Kasus Putusan Kasasi MA No. 787 K/Pdt/2013)
Authors: Santoso Sigit Dwi
Published: June 2020

Permasalahan pertanahan merupakan isu yang selalu muncul dan selalu aktual dari masa ke masa. Salah satu permasalah tanah adalah kasus sengketa tanah yang terjadi di kabupaten Sleman, yang telah diperiksa dan dikeluarkan putusan pada tingkat kasasi dengan putusan Mahkamah Agung No. 787 K/Pdt/2013 pada tanggal 17 Desember 2013, yang salah satu putusannya adalah â€œmenyatakan tidak sah dan batal menurut hokum pada Akta Jual Beli Nomor 141/2004 tanggal 26 November 2004â€. Tentunya ini menimbulkan isu hukum, berupa â€œkeberadaan akta jual beli yang dibuat oleh PPAT yang merupakan sebuah akta otentikâ€. Di akhir tulisan ini disimpulkan dua hal. Pertama, keberadaan putusan ini telah menunjukkan adanya perlindungan hokum, dalam bentuk: menyatakan tidak sah dan batal menurut hokum terhadap jual beli tanah tersebut karena tidak sesuai dengan hokum adat, yaitu bersifat tunai, terang, dan riil/nyata. Kedua, keberadaan putusan ini telah menunjukkan adanya kepastian hokum, dengan menyatakan tidak sah dan batal menurut hokum terhadap Akta Jual Beli Tanah yang dibuat oleh PPAT.
Kewenangan Notaris dalam Membuat Akta Roya Hak Tanggungan
Authors: Purnama Yusuf Bagus
Published: June 2020

Akta roya hak tanggungan biasanya dibuat oleh Kantor Pertanahan yang menandakan bahwa piutang kreditor telah lunas atau sertifikat hak tanggungan dicoret karena sudah hapus. Namun karena sertifikat hak tanggungan yang dikuasai oleh kreditor hilang, maka dalam hal hak tanggunganya hapus tidak bisa dilakukan pencoretan dalam sertifikat hak tanggungan. Dalam hal ini kreditor memerlukan akta roya hak tanggungan secara notariel atau akta yang dibuat oleh notaris.  Akta roya hak tanggungan merupakan salah satu akta otentik yang dibuat notaris atas permintaan kreditor sebagai pihak yang berisi pernyataan pihak kreditur bahwa sertipikat hak tanggungan debitor yang berada dalam kekuasaannya telah hilang. Keberadaan akta roya hak tanggungan dalam ruang lingkup hak tanggungan belum diatur secara tegas dalam UUJN, UUHT dan peraturan lainnya, namun notaris dapat membuat akta ini dengan berlandaskan kewenangan notaris sebagaimana Pasal 15 ayat (1) UUJN. Dalam ketentuan tersebut terdapat adanya norma kabur mengenai kewenangan notaris untuk membuat akta roya hak tanggungan. Permasalahan yang diangkat dalam penelitian ini adalah tentang kewenangan notaris membuat akta roya hak tanggungan, dan kedudukan aka roya hak tanggungan yang dibuat oleh notaris. Hasil penelitian ini menunjukkan bahwa secara umum notaris berwenang membuat akta notariel berupa akta roya hak tanggungan berdasarkan Pasal 15 ayat (1) UUJN, selama tidak ada aturan lain yang lebih khusus mengatur hal tersebut. Akta roya hak tanggungan merupakan akta notariil yang mempunyai kedudukan sebagai pengganti sertifikat hak tanggungan yang hilang, yang berfungsi sebagai syarat pendaftaran roya atau pencoretan hak tanggungan.