bluuebunny/crossref_metadata_2025 huggingface dataset:
Traumafolgestörungen – Handlungsleitlinien für die Personzentrierte Psychotherapie mit Kindern, Jugendlichen und Bezugspersonen
Authors: Hüsson Dorothea , Döring Else , Riedel Klaus
Published: December 2023

In dem Artikel werden personzentrierte Entwicklungen im Rahmen eines störungsorientierten Vorgehens und Erkenntnisse der Traumatheorie zusammengetragen und in Theorie und Anwendung für die Therapie mit Kindern und Jugendlichen dargestellt. Erlebte Psychotraumata führen häufig zu Traumafolgestörungen wie z. B. Posttraumatische Belastungsstörung oder Dissoziationen. Sie nehmen gerade bei Kindern und Jugendlichen einen speziellen Verlauf, der z. B. im Rahmen des posttraumatischen Spiels sichtbar wird. Therapeutisches Vorgehen erfordert daher ein differenziertes Wissen aus Entwicklungspsychologie und Traumatheorie. Die Diagnostik muss, neben der kindzentrierten Ausrichtung, stark am Störungsbild orientiert sein, um eine Retraumatisierung zu vermeiden. Das therapeutische Vorgehen in den einzelnen Therapiephasen sollte personzentriert am Störungsverständnis und an den Bedürfnissen des Kindes/Jugendlichen ausgerichtet sein. Die Elternberatung ist an die spezifischen Herausforderungen, die die kindliche und oft auch familiäre Traumatisierung mit sich bringt, gebunden. Besonders in Fällen komplexer Traumatisierungen ist die personzentrierte Kinder- und Jugendlichenpsychotherapie gut geeignet, um traumatische Erfahrungen auf behutsame Weise in das Selbstkonzept der Kinder/Jugendlichen zu integrieren.
Examining the Digital Divide in Education during COVID-19 from Teachers' Perspectives
Authors: Ceviker Elife , Gezer Tuba
Published: December 2023

The outbreak of COVID-19 resulted in unprecedented school closures in education, leading online education to become “the new normal.” Concurrently, emergency online instruction further exacerbated what is known as the digital divide, one of the contributing factors to inequality of educational opportunities. The purpose of our research is to examine in what ways the digital divide influences teachers and students during COVID-19. A better understanding of teachers' perceptions of teaching online and the digital divide can offer more information for effective teaching during the pandemic. In this multi-method study, researchers collected data from 36 teachers through Likert scale questions and open-ended survey questions. The findings indicated that first- and second-level digital divides are the main problems affecting online education during the COVID-19 outbreak. Some students might not benefit from online learning due to the digital divide. Lack of access to technology and the internet, first-level digital divide, affected primarily students from lower SES. Further, even though some students had access to technology and the internet, students' and teachers' information and communication technology (ICT) skills, second-level digital divide, impacted how they use technology and profit from online education. Teachers need support to improve their own ICT skills, as well as their students, to reduce the impact of the digital divide in education.
Making the Most of the Peer Review Process
Authors: Horner Christy , Horner Sherri , Maguire Richard
Published: December 2023

In this brief mentoring corner article, we focus on defining what different editorial decisions mean (e.g., accept with revisions; revise and resubmit; reject: revise and resubmit), discussing factors you might consider when deciding what to do after receiving a decision (e.g., resubmit or move on) and considering how to best approach the revisions. We also provide guidance on effective communication with editors, including an example of a successful response to review table and cover letter.
Criminal Law Enforcement of Book Copyright Infringement in Digital Market Places in The Ecosystem E-Commerce Through Restorative Justice
Authors: Putra Mohamad Rizki Agung
Published: December 2023

The enforcement of criminal law against book copyright infringement in Indonesia is inadequate, lacking legal certainty and failing to provide restorative justice for copyright holders due to outdated regulations. This study, using a normative juridical approach with descriptive analysis and empirical comparison, reveals that such enforcement is categorized as a 'complaint offense,' starting with the reception of complaints and proceeding to mediation, followed by judicial processes if mediation fails. It also highlights that copyright protection involves automatic regulatory mechanisms, a registration system for exclusive, moral, and economic rights, and combines proactive educational outreach with repressive marketplace monitoring and customs collaborations. Furthermore, the research explores Restorative Justice, focusing on mediation and arbitration in commercial courts for fair restitution, aiming to compensate materially and morally. The findings suggest expanding restitution concepts in Restorative Justice to align with global copyright norms and the growth of E-Commerce, thereby enhancing protection for copyright holders in the digital era.
Salud mental y recursos de afrontamiento en pacientes hospitalizados por COVID-19
Authors: Correa Ramírez Cristian , Acevedo Moreno Juliana , Cano Arias Santiago
Published: December 2023

El objetivo de la presente investigación es analizar las distintas características psicosociales y los recursos de afrontamiento de los pacientes hospitalizados por COVID-19, destacando sus efectos en la salud mental, a partir de los relatos y las experiencias identificadas en las historias clínicas de la Clínica Universitaria Bolivariana entre el 1 de julio y el 31 de octubre de 2020. La investigación, con un enfoque cualitativo y un diseño hermenéutico de tipo documental, realizó un muestreo por criterios de inclusión no probabilístico, en el cual se identificaron 61 historias clínicas que cumplían los requerimientos definidos previamente. Los resultados evidencian que durante la experiencia hospitalaria emergen una amplia gama de situaciones que involucran la presencia de un malestar emocional, de una percepción de soledad y un reconocimiento de pérdidas; a su vez, los pacientes emplean una diversidad de estrategias de afrontamiento en un proceso adaptativo que permite construir un escenario de bienestar. El estudio recoge diversas singularidades inscritas en el marco de estresores significativos que enfrentan los pacientes en un contexto de aislamiento hospitalario; en esta perspectiva las reflexiones derivadas podrían ampliarse a poblaciones que en otros contextos afrontan fuertes medidas de aislamiento por motivos de bioseguridad hospitalaria. Las demandas psicosociales encontradas permiten concluir que es fundamental el acompañamiento psicosocial y la construcción de equipos de salud sensibles a los fenómenos vinculados con la salud mental de los pacientes.
PENERAPAN MODEL PROBLEM SOLVING DALAM PEMBELAJARAN PENDIDIKAN AGAMA HINDU DAN BUDI PEKERTI DI KELAS XI SMA NEGERI 3 DENPASAR
Authors: Praningsih Niluh Ayu , Winanti Ni Putu , Prabawati Kusuma Dewi Ni Wayan
Published: December 2023

Pedidikan merupakan salah satu hal penting dalam menentukan maju mundurnya suatu bangsa, Modal Pembelajaran memegang peranan penting dalam pencapaian Pendidikan, Model pembelajaran sangat menentukan tujuan Pendidikan di SMA Negeri 3 Denpasar telah menerapkan Model Problem Solving dalam pembelajaran Pendidikan Agama khususnya Pendidikan Agama Hindu dan Budi Pekerti yang layak untuk di teliti. Adapun rumusan masalah yang dibahas antara lain: Penelitian ini menjelaskan bentuk pelaksanaan kegiatan Pembelajaran dengan menerapkan Model Problem Solving dalam Pembelajaran penerapan Model Problem Solving dalam Pembelajaran Pendidikan Agama Hindu dan Budi Pekerti di kelas XI SMA Negeri 3 Denpasar. upaya guru dalam menerapkan Model Problem Solving dalam Pembelajaran Pendidikan Agama Hindu dan Budi Pekerti di kelas XI SMA Negeri 3 Denpasar. dampak dari penerapan Model Problem Solving dalam Pembelajaran Agama Hindu dan Budi Pekerti di kelas XI SMA Negeri 3 Denpasar. Teori yang digunakan dalam penelitian ini yaitu: konstruktvisme, Behavioristik. jenis penelitian ini adalah dengan penelitian studi kasus sedangkan pengumpulan data mengguakan beberapa teknik atau metode yaitu: observasi, wawancara, dokumentasi, studi kepustakaan.
Hasil peneliti meunjukkan bahwa: (1) Pelaksanaan pembelajaran Model problem solving dalam pembelajaran Pendidikan Agama Hindu Dan Budi Pekerti meliputi: Perecanaan, pelaksanaan dan refleksi pembelajaran. (2) Upaya guru dalam menerapan model problem solving merupakan suatu proses pembelajaran yang di gunakan di SMA Negeri 3 denpasar dalam penerapan ini ada beberapa upaya-upaya yang dilakukan guru, upaya yang dilakukan yaitu: Upaya mengaplikasikan teknologi dalam proses pembelajaran dan mempersiapkan media pembelajaran yang memadai, serta pemecahan masalah dengan membentuk kelompok kecil. (3) Dampak atau implikasi Model Problem Solving dalam pembelajaran Pendidikan Agama Hindu dan Budi pekerti ini menigkatkan motivasi belajar siswa dan meningkatkan hasil belajar siswa memberikan dampak bagi guru, siswa dan sekolah, dampak inilah yang akan memberikan respon dan hasil pembelajaran pada siswa dan guru saat proses pembelajaran berlangsung di dalam kelas dengan Model Problem Solving ini.
The functions of Korean proverbs in the political discourseof the English-language media of South Korea
Authors: Shekhovtsova Tatyana Akimovna
Published: December 2023

The research is devoted to the study of Korean proverbs functioning in the political discourse of the English-language media of South Korea, the definition of their communicative and pragmatic functions. The aim of the study is to identify the features of the Korean paremiological units usage in English-language political media texts. To solve the tasks set in the work, the following research methods were used: communicative-pragmatic analysis based on the interpretation of the meaning and functions of proverbs within the context of a contextual situation; comparative analysis of paroemias in the context of interlanguage communication. To determine the role of paremiological units in the political texts in the communication process, elements of discursive analysis were also applied. The scientific novelty of the study is determined by the fact that the functions of Korean proverbs are for the first time analyzed in the context of the English-speaking modern Internet media of South Korea. The development of the methodology for analyzing the functioning of the communicative and pragmatic functions of Korean proverbs in political mass media discourse should also be mentioned. According to the results, depending on the context, Korean proverbs in English-language media texts, performing a wide range of general linguistic and grammatical functions, are rarely used as exclusively directive statements. Based on the discursive situation and the personal intention of the author in highlighting a certain level of content of the proverb, the paremia can perform various functions. The multifunctionality of Korean proverbs allows the author to influence the reader regardless of belonging to the culture of the country. The research materials can be used to expand the content of practical courses for students of philological and linguistic specializations of universities, in applied educational activities.
Galvas smadzeņu kvalitatīvu un kvantitatīvu radioloģisko biomarķieru izmaiņu saistība ar kognitīvo funkciju izmaiņām un demenci. Promocijas darbs
Authors:   ,   Rīgas Stradiņa universitāte, Zdanovskis Nauris
Published: December 2023

Populācijas demogrāfiskās izmaiņas un neirodeģeneratīvu slimību savlaicīga diagnostika un ārstēšana ir viens no lielākajiem izaicinājumiem Eiropā un pasaulē 21. gadsimtā. Promocijas darbā tiek aplūkotas magnētiskās rezonanses (MR) izmeklējuma iespējas, analizējot pētījuma dalībniekus ar kognitīvajiem traucējumiem. Darba mērķis ir noteikt galvas smadzeņu kvalitatīvo un kvantitatīvo biomarķieru saistību ar kognitīvo funkciju pacientiem ar kognitīvajiem traucējumiem. Pētījuma literatūras apskata sadaļā tiek raksturots kognitīvo traucējumu un demences jēdziens, biežāk izmantotie kognitīvie testi, aprakstītas biežāk izmantotās kvalitatīvās vizuālās novērtēšanas skalas un izvērtēta kvantitatīvo biomarķieru izmantošana kognitīvo traucējumu diagnostikā. Materiālu sadaļā ir izvērtēti dalībnieku demogrāfiskie rādītāji, dalībnieki tiek iedalīti grupās un izvērtētas atšķirības starp dalībnieku grupām. Kopumā tika analizēts 81 dalībnieks, no kuriem 24 nav kognitīvo traucējumu un 57 ir dažādas pakāpes kognitīvie traucējumi, kas tika izvērtēti pēc Monreālas kognitīvās novērtējuma (MoCA) skalas. Metožu sadaļā tiek izvērtēts statistisko metožu lietojums, kas ietver Manna-Vitnija U testu, Kruskala-Valisa H testu, post-hoc analīzi, p vērtību korekciju pēc Bonferoni, Spīrmena korelācijas, principiālo komponentu analīzi. Rezultāti norāda, ka noteikti galvas smadzeņu radioloģiskie biomarķieri ir saistīti ar kognitīvo funkciju rezultātiem, t. sk. gan kvalitatīvās novērtēšanas skalas, gan kvantitatīvās tilpuma, garozas biezuma un baltās vielas šķiedru raksturlieluma vērtības. Šīs noteiktās saistības ir kā pamats tālākiem pētījumiem par kvantitatīvo radioloģisko biomarķieru izmantošanu kognitīvo traucējumu diagnostikā, lai nākotnē spētu agrīni identificēt pacientus, kas ir kognitīvo traucējumu attīstības riska grupā. Secinājumos tiek apstiprinātas darba gaitā izvirzītās hipotēzes – galvas smadzenēs kognitīvo traucējumu un demences gadījumā notiek strukturālas pārmaiņas, kas ir konstatējamas MR attēlos, veicot galvas smadzeņu struktūru kvalitatīvu un kvantitatīvu analīzi, un kognitīvie traucējumi ir saistīti ar specifiskām izmaiņām galvas smadzeņu MR kvantitatīvajos rādītājos. Kopumā MR izmeklējums spēj ne tikai izslēgt lielas patoloģijas, bet arī sniegt daudz plašāku un detalizētāku informāciju par anatomiskām un strukturālām izmaiņām, kas ir būtiskas kognitīvo traucējumu diagnostikai, kontrolei un intervences izvērtēšanai ilgtermiņā. 3.2. klīniskā medicīna; apakšnozare – rentgenoloģija un radioloģija. Atslēgvārdi: galvas smadzenes, radioloģiskie biomarķieri, kognitīvās funkcijas, demence, magnētiskā rezonanse. Promocijas darbs veikts projekta Nr. 8.2.2.0/20/I/004 “Atbalsts doktorantu iesaistei zinātniski pētnieciskajā un studiju darbā” ietvaros.
AN OUTBREAK OF HFRS IN THE SARATOV REGION IN 2019 WERE CAUSED BY PUUMALA VIRUS STRAINS IMPORTED FROM UDMURTIA
Authors:   Central Research Institute of Epidemiology, Moscow, Blinova E.A. , Kresova U.A. , Dzagurova T.K. ,   Center for Hygiene and Epidemiology in the Saratov Region,   3Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products RAS, Moscow
Published: December 2023

In Russia, the Puumala virus is the most important pathogen causing hemorrhagic fever with renal syndrome (HFRS). This study demonstrated, that the genome variants of the Puumala virus that caused the outbreak of HFRS in the Saratov region in 2019 are descendants of strains circulating in Udmurtia, which were presumably introduced into the territory of the Saratov region by anthropogenic transfer downstream of the Kama and Volga rivers.
DEVELOPMENT OF EXPERIMENTAL AND ANALYTICAL METHODOLOGY FOR DETECTION OF NEW VIRUSES BASED ON NGS TECHNOLOGIES
Authors:   Central Research Institute of Epidemiology, Moscow, Borisova N.I. , Roev G.V. , Agletdinov M.R. , Chistyakova N.V. , Khafizov K.F. ,   Moscow Institute of Physics and Technology, Dolgoprudny,   Severtsov Institute of Ecology and Evolution RAS, Moscow
Published: December 2023

Different estimates suggest that we only know a small fraction of existing viruses, with less than 1 % of their genomes represented in databases. The combination of NGS and single-primer amplification techniques allows us to not only identify sequences that may pertain to unknown viruses, but also to gather a more comprehensive understanding of their nucleotide composition.
FUNCTIONAL AND MORPHOLOGICAL ASSESSMENT OF THE STATE OF LYMPHOID CELLS DURING HIV INFECTION IN VITRO USING FLOW CYTOMETRY WITH VISUALIZATION
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Elfimov K.A. , Gashnikova M.P. , Gotfrid L.G. , Gashnikova N.M. ,   Novosibirsk State University
Published: December 2023

T-lymphocytes are an important object in the study of HIV infection. There are many methods for assessing their functional state, but morphological assessment is usually bypassed or a visual examination is carried out. In this work, a number of precise parameters were studied as markers of the morphological and functional state of T-lymphocytes in order to study the cytopathic effect of HIV on human lymphoid cells.
PORCINE PARVOVIRUS TYPE 6 IN RUSSIA, DISTRIBUTION AND IN VITRO CHARACTERIZATION
Authors:   All-Russian Research Institute of Experimental Veterinary Medicine named after K.I. Scriabin and Y.R. Kovalenko, Komina A.K. , Anoyatbekova A.M.
Published: December 2023

The present study demonstrates the identification of Porcine parvovirus 6 (PPV6) in Russia and its characterization in vitro. During the study, we investigated 521 serum samples collected from pigs of different ages from seven regions of the Russia. The overall prevalence of PPV6 in Russia is 9,4 %. In vitro studies of the virus demonstrated that the virus accumulates in SPEV and SK continuous cell cultures
MONITORING OF THE SPREAD OF SARS-COV-2 VARIANTS IN THE SVERDLOVSK AND CHELYABINSK REGIONS
Authors:   Federal Scientific Research Institute of Viral Infections “Virom”, Ekaterinburg, Chernysheva A.E. , Korotkova I.A. , Bolgarova E.V. , Markaryan A.Yu.
Published: December 2023

The paper demonstrates the results of sequencing samples from patients with a new coronavirus infection COVID-19, clearly shows the dynamics of the circulation of the SARS-CoV-2 virus in the Sverdlovsk and Chelyabinsk regions for 6 months of 2023.
EFFECT OF THE ATI GENE DELETION ON PATHOGENICITY AND IMMUNOGENICITY OF THE VACCINIA VIRUS
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Shulgina I.S. , Yakubitskiy S.N. , Sergeev A.A. , Titova K.A. , Borgoyakova M.B. , Starostina E.V. , Karpenko L.I. , Shchelkunov S.N.
Published: December 2023

Among nonvirion proteins of the vaccinia virus (VACV), a 94-kDa protein (a truncated form of ATI protein) is synthesized in the largest quantity. This protein is a major immunogen upon infection of humans and animals with VACV. Meanwhile, antibodies specific to this protein are not virus-neutralizing. The present study aimed to investigate the effect of production of this protein on manifestation of pathogenicity and immunogenicity of VACV in a mouse model.
Distribution of large bivalves of the genus Lanceolaria (Bivalvia: Unionidae) in Primorsky Krai in 2023
Authors:   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Prozorova Larisa A. , Barabanshchikov Evgeny I. ,   Pacifi c Branch of VNIRO (TINRO), Vladivostok, 690091, Russian Federation
Published: December 2023

Information on the distribution of two endemic species of large bivalves in the Primorsky Krai has been clarifi ed. Both species are listed in the Red Data Book of the Russian Federation: Lanceolaria maacki Moskvicheva, 1973 and L. chankensis Moskvicheva, 1973. Currently known populations of these species are listed together with an assessment of their condition. A reduction in the number and area of distribution of the species is demonstrated. The main threats and ways for the Lanceolaria species conservation in Lake Khanka and the Ussuri River are discussed.
18th International Scientifi c Conference “Diatoms: Morphology, Biology, Systematics, Ecology, Floristic, Paleogeography, Biostratigraphy”
Authors:   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia, Avramenko Aleksandra S. , Cherepanova Marina V. ,   Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia
Published: December 2023

XVIII International Scientifi c Conference “Diatoms: Morphology, Biology, Systematics, Ecology, Floristic, Paleogeography, Biostratigraphy” took place between August 28 and September 3, 2023 at the Federal Research Centre Kola Science Centre of the Russian Academy of Sciences, Apatity, Russia. Seventy three leading experts and young scientists from 37 institutions in 24 Russian cities (from Sevastopol and Feodosia to Irkutsk, Yakutsk and Vladivostok) participated in the conference. Some participants came from Belarus (Minsk) and Israel (Haifa). Fifty one persons presented oral and poster reports, 22 presented their reports online.
Residência multiprofissional em saúde da família em Pernambuco: do compromisso teórico ao fazer profissional no território
Authors: Mota Marina Mayra de Lima , Ribeiro Layta Sena , Silva Graciele Rodrigues Nunes da , Mendes Thiere José Cristovão , Silva Paloma Beatriz Costa , Silva Crysllaine Pinheiro da , Silva Débora Verônica Sarmento Pereira da , Silva Dayana Roberta da , Ribeiro Jéssica Francisca Soares , Alves Nathália da Silva Soares
Published: December 2023

Objetivo: Versar sobre a experiência de residentes em Saúde da Família na cidade do Recife-PE, descrevendo seus processos de trabalho no contexto da atenção primária. Relato de experiência: Discute-se desde a organização dos ministérios da saúde e da educação envolvidos na construção das residências em saúde no Brasil, ao quadro da formação do programa específico dos autores que se operacionaliza através de grupos chamados de núcleos de base (NB), em uma perspectiva freiriana. Ademais, descreveu-se como se dá a formação teórica por meio de temáticas como: Estado, Sociedade e Políticas de Saúde; Epidemiologia descritiva; Educação Popular; Família, Gênero e Raça; Ciclos de vida; Planejamento em Saúde e Metodologia Científica, a fim de abarcar o contexto da pesquisa no território e na conclusão no curso. Também explanou-se sobre as ações empregadas no território, sua importância e instrumentalização, a saber: acolhimento, atendimentos individuais e compartilhados, visita domiciliar, ações coletivas, matriciamento, além de atividades que se dão em outros espaços institucionais. Considerações finais: Para avaliar a experiência, aglutinou-se, por fim, as potencialidades e desafios, com base nas vivências em território, como a multiprofissionalidade e o baixo investimento em educação permanente, consecutivamente.
Fatores sociodemográficos relacionados a violência doméstica contra a mulher em um munícipio paraibano
Authors: Meira Mary Luce Melquiades , Gomes Isabel Cristina , Lucena Débora de Souza , Negreiros Rosângela Vidal de , Castro Anúbes Pereira de , Leite Iracema Filgueira , Fonseca Emanuel Nildivan Rodrigues da , Sousa Andréia Oliveira Barros , Mendonça Aldineide Fernandes de Araújo , Barbosa Gyovanna Vicktória Araújo
Published: December 2023

Objetivo: Analisar o comportamento das notificações de violência doméstica contra a mulher no decorrer dos anos e associar os fatores sociodemográficos com o tipo de violência. Métodos: Estudo transversal, descritivo, ecológico, realizado com dados registrados no Sistema de Informação de Agravos e Notificação, com base nas fichas de notificação de violência interpessoal/autoprovocada de 2018 a 2022, cujas vítimas tivessem a partir de 19 anos; tendo como cenário o munícipio de Campina Grande. Resultados: Foram analisadas 258 fichas de notificação de violência quanto ao tipo de violência prevalente e sua associação com variáveis sociodemográficas, assim como a caracterização dos agressores; os resultados constatam que a maioria das vítimas possuíam baixo grau de escolaridade, menores condições financeiras e algumas não conseguiam identificar determinados comportamentos como violência. Conclusão: Este estudo permitiu compreender as características da violência, entretanto, apresenta fragilidade com relação aos dados quanto a subnotificação, assim como a notificação indevida por parte dos profissionais; desse modo, evidencia-se a necessidade de trabalhar estratégias de capacitação com os profissionais e, espera-se que os dados apresentados neste estudo possam contribuir para a elaboração de ações de prevenção e enfrentamento à violência contra a mulher.
Macular telangiectasia type 2
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Brunch, St. Petersburg, Russian Federation, Ageeva O.V. , Gatsu M.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Brunch, St. Petersburg, Russian Federation,   I.I.  Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation
Published: December 2023

Purpose. To summarize the data on the etiology, pathogenesis, diagnostic methods, and treatment of macular telangiectasia type 2 (MacTel 2) currently known. Material and methods. For this review, a search was conducted on PubMed and eLIBRARY resources, covering scientific publications by domestic and foreign authors from 1980 to 2021. The primary focus of the search was on the topic of MacTel 2. Results. Based on the current understanding of the disease process, it is recognized that dysfunction or loss of Muller cells represents an early stage that contributes to the development of MacTel 2. The review addresses the issues of diagnosis and differential diagnosis, pathogenesis, classification, clinical presentation, and treatment of MacTel 2. Detailed discussion is provided on the changes detected by optical coherence tomography in patients with MacTel 2, which can be valuable for the differential diagnosis of this condition and selection of appropriate patient management strategies. Conclusion. The emergence of new technologies enables the identification of specific changes occurring in the retina in MacTel 2, which require detailed analysis and can be used for differential diagnosis and disease prognosis. Key words: macular telangiectasia type 2, retinal degenerative disease, Muller cells, optical coherence tomography, differential diagnosis
Selection of keratometric data for the IOL toricity calculation
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg brunch, St. Petersburg, Russian Federation, Shukhaev S.V.
Published: December 2023

Purpose. To elaborate the customized principle of determining the actual zone of the corneal astigmatism based on keratotopographic data and compare the accuracy of calculating the toric IOL according to the actual zone and conventional keratometry. Material and methods. The study included 48 patients (48 eyes) who underwent toric IOL implantation. 3–6 months (5.1±0.6) after surgery, all patients were measured the residual refractive astigmatism. The toric IOL was retrospectively calculated according to the data of the actual keratotopographic zone determined by the proposed method (1st group) and according to conventional keratometry (2nd group). Vector and centroid analyses were used to estimate the error in calculating the IOL toricity. Results. The principles of determining the actual zone are based on the assumption that maximum visual acuity and visual quality can be achieved when the regularity of astigmatism in the central parts of the cornea corresponds to the regularity of toric IOL. The mean diameter of the selected actual zone was 2.93±0.61 (from 2.0 to 4.3 mm respectively). The average vector error of toricity calculation in 1st group was 0.30±0.31, in 2nd group – 0.42±0.30 (p=0.006). Centroid analysis showed similar values of centroid error in 1st group and 2nd group (0.09 and 0.08), while the dispersion was higher in 2nd group (0.42 and 0.51, respectively). Conclusion. The customized principle of selecting the actual zone according to topographic maps of the cornea showed a more accurate calculation of the IOL toricity compared with the use of conventional keratometry data. Key words: toric IOL, corneal astigmatism, IOL calculation accuracy, keratometry, keratotopography
Results of neurotrophic keratopathy treatment by direct corneal neurotization
Authors:   Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Russian Federation, Gushchina M.B. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga branch, Kaluga, Russian Federation, Butsan S.B. ,   Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Russian Federation, Sergeeva V.Y. ,   Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Russian Federation, Salikhov K.S. ,   Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Russian Federation, Tereshchenko A.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga branch, Kaluga, Russian Federation, Erokhina E.V. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga branch, Kaluga, Russian Federation, Malkov S.A. ,   Russian Medical Academy of Continuing Professional Education of the Ministry of Health, Moscow, Russian Federation
Published: December 2023

Relevance. Trigeminal nerve defeat can lead to the development of neurotrophic keratopathy. The only pathogenetically justified method of treating this pathology is corneal neurotization. Purpose. To develop rehabilitation tactic for the patients with neurotrophic keratopathy based on the analysis of the results of operations performed according to the author's technique of direct corneal neurotization. Material and methods. 10 direct corneal neurotizations: with initial manifestations – in 2 cases and in the advanced stage of neurotrophic keratopathy – in 8 cases. Results and discussion. Postoperative period proceeded without complications. Corneal sensitivity was restored in 60%. In all cases, corneal transparency improved, the density of the eyesore and the depth of the invasion of opacities decreased, subbasal nerve fibers began to be visualized, positive dynamic in the state of tear production were observed. Perforation defects of the cornea was closed. In initial stage of the disease corneal opacity has almost completely regressed. Conclusion. Direct corneal neurotization provides restoration of its sensitivity, prevention of neurotrophic keratopathy, which provides medical and social rehabilitation. Key words: facial nerve, paralytic lagophthalmos, abductive nerve, convergent paralytic strabismus, trigeminal nerve, corneal innervation, corneal opacity, corneal sensitivity, esthesiometry, supraorbital nerve, supratrochlear nerve
New data on intensive Earth degassing in the Arctic in the north of Western Siberia: thermokarst lakes with gas blowout craters and mud volcanoes
Authors:   Oil and Gas Research Institute of RAS, Bogoyavlensky V.I. , Nikonov R.A. ,   Oil and Gas Research Institute of RAS, Bogoyavlensky I.V. ,   Oil and Gas Research Institute of RAS
Published: December 2023

In the last decade, in the north of Western Siberia, the authors carried out a large amount of comprehensive research, which made it possible to obtain fundamentally new information about the gas-dynamic mechanisms of dangerous processes in the Arctic permafrost. According to remote sensing data, at the bottom of thermokarst lakes, rivers and coastal zones of the Kara Sea, more than 4.5 thousand zones of powerful gas blowouts with the formation of craters (pockmark) were found. There are reasons to believe that powerful gas emissions mainly come from shallow deposits with ultrahigh (superlithostatic) pressures. For the first time, large mud volcanic uplifts with pronounced craters have been found at the bottom of the Arctic thermokarst lakes. Based on the monitoring of the ice situation and the water environment on the basis of retrospective satellite images on lakes Otkrytie, Labvarto and Yambuto, the presence of periodic emissions of formation fluids, including gas, is shown. Based on the combination of a number of features, the discovered objects can be classified as active mud volcanoes with a high level of probability. The results of the studies allow us to state that mud volcanism is widespread in the Circum-Arctic megaregion.
Spatial and temporal changes in territorial social systems in the Yamalo-Nenets Autonomous Area
Authors:   Tyumen State University, Petrov Y.V.
Published: December 2023

The Yamalo-Nenets Autonomous Area is an Arctic resource-producing region, where oil and gas resources have been extracted for a long time. The study purpose is a spatial assessment of changes in territorial social systems on the basis of population census materials. With this aim, the author has completed sequentially 4 tasks: 1) assessment of the current network of the of settlement organization; 2) study of the historical parameters of the environmental management in the pre-oil-gas period; 3) identification of priority diversifying areas in the historical context; 4) determination of mechanisms for planning balanced long-term development. The data sources are the materials of the state population censuses of 1926, 1989, 2002, 2010 and 2021. Research methods: mathematical, geoinformation, historical. While solving the first task, the author has applied the Zipf rule to estimate the ratio of the urban population in the Autonomous Area in 1989, 2002, 2010, 2021. For the tasks 2-4, he has carried out a comparative spatial assessment of the development of economic subdistricts in 1926. Due to the Arctic conditions, the implementation of full-fledged socio-economic development of each of the directions requires the participation of state regional structures, including at the administration level for the safe traditional environmental management. Regulatory state management, first of all, is necessary in the field of reindeer herding and fishing. Mechanisms are proposed for the formation of certain types of environmental management as diversifying the economy of the Yamalo-Nenets Autonomous Area.
Assessment of environmental safety and energy security for the development options of heat supply to a settlement in the Arctic
Authors:   V. P. Larionov Institute of the Physical-Technical Problems of the North of the Siberian Branch of the RAS, Pavlov N.V. , Zakharov V.E. ,   V. P. Larionov Institute of the Physical-Technical Problems of the North of the Siberian Branch of the RAS, Prokhorov D.V. ,   V. P. Larionov Institute of the Physical-Technical Problems of the North of the Siberian Branch of the RAS, Ivanova A.E. ,   V. P. Larionov Institute of the Physical-Technical Problems of the North of the Siberian Branch of the RAS, Petrova T.N. ,   V. P. Larionov Institute of the Physical-Technical Problems of the North of the Siberian Branch of the RAS, Vasiliev S.S. ,   V. P. Larionov Institute of the Physical-Technical Problems of the North of the Siberian Branch of the RAS, Ivanova I.Y. ,   Melentiev Energy Systems Institute of Siberian Branch of the Russian Academy of Sciences, Maysyuk E.P. ,   Melentiev Energy Systems Institute of Siberian Branch of the Russian Academy of Sciences
Published: December 2023

The article presents the results of comparing the environmental performance of district and individual heating options on the example of a settlement located in the Arctic territory of the Republic of Sakha (Yakutia). The thermal energy source for the district option is a coal-fired boiler house; the one for the individual option is automated pellet boilers. The boiler house receives coal according to a complex multi-link scheme, whereas pellets are produced on site. The district heating option involves laying heat networks throughout the village because currently it has none. The individual heating option suggests the construction of a pellet production plant. Environmental indicators are calculated emissions of pollutants and carbon dioxide emissions from fuel combustion. Pollutants include solids, sulfur dioxide, nitrogen oxides, and carbon monoxide. Along with environmental indicators, the authors consider the conditions for ensuring energy security in various heating options. The research findings show the advantage of the individual heating option based on automated pellet boilers for environmental indicators. The risks for this option are assessed from the standpoint of threats to the energy security of the settlement in comparison with the district heating option. The factors considered as threats include those affecting the reliability and survivability of process technologies, an increase in the thermal energy cost, and the availability of fuel and energy resources. The main limitation for the option of individual heating in the Arctic territories, which is based on locally produced wood pellets, is the lack of reasonable reserves of available wood in wood-cutting areas near the settlement.
Analisis Strategi Pemanfaatan Media Komunikasi KPU Kota Makassar dalam Meningkatkan Partisipasi pemilih pada Pilkada Serentak tahun 2020
Authors: Kasim Sri , Febri Sonni Alem , Farid Muhammad
Published: December 2023

Pelaksanaan Pemilihan Kepala Daerah serentak tahun 2020 menjadi Pilkada pertama yang dilaksanakan dimasa Pandemi Covid-19. Aturan serta kebijakan yang ditetapkan oleh pemerintah dalam menanggulangi penyebaran Covid-19 menjadi tantangan terbesar bagi Komisi Pemilihan Umum sebagai penyelenggara pilkada dalam menghadapi terpaan isu akan rendahnya minat masyarakat untuk hadir dan menggunakan hak pilihnya di TPS. Dalam meningkatkan partisipasi pemilih, KPU Kota Makassar yang juga penyelenggara pilkada menghadapi tantangan tersebut dengan menggunakan strategi melalui pemanfaatan media komunikasi. Media Komunikasi telah banyak dimanfaatkan untuk menunjang pelaksanaan sosialisasi dalam meningkatkan partisipasi pemilih pada pemilihan kepala daerah. Penelitian ini bertujuan untuk menganalisis strategi yang digunakan KPU Kota Makassar dalam memanfaatkan media komunikasi guna meningkatkan partisipasi pemilih pada Pilkada Serentak tahun 2020 yang dilaksanakan dimasa Pandemi Covid-19. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan pengumpulan data yang dilakukan dengan cara observasi, wawancara dan studi dokumentasi. Penelitian ini melakukan Teknik pemilihan informan menggunakan purposive sampling. Hasil dari penelitian ini menemukan bahwa strategi yang dilakukan melalui pemanfaatan media komunikasi oleh KPU kota Makassar dapat memaksimalkan pelaksanaan tahapan sosialisasi di masa pandemi melalui berbagai bentuk media sosial sehingga dapat mendongkrak minat pemilih untuk berpartisipasi dalam pilkada serentak tahun 2020.
Detrimental Effects of Lithium on in vitro Seedlings of Pea (Vigna radiata)
Authors: Dilsha Davis , Narasimhan S.
Published: December 2023

The global demand for lithium-ion batteries has raised concerns about environmental consequences stemming from lithium leaching. In this study, we investigated the effects of lithium, sourced from Li2SO4, on in vitro seed germination and seedling growth of green moong (Vigna radiata). Our experiments used woody plant medium supplemented with 1 mg/l naphthalene acetic acid (NAA) and 2 mg/l benzyl adenine (BA). We observed that in vitro seed germination remained unaffected by lithium concentration. However, at concentrations of 3-5 mg/l of lithium, significant changes were observed in stem parameters including growth reduction, shoot tip damage and stem discolouration. Root growth was inhibited at lithium concentrations of 4 and 5 mg/l. Additionally, we noted leaf abscission, dark colouration and reduced leaf area in a dose-dependent manner. Necrotic lesions were not observed in the seedlings. Chlorophyll accumulation, phenolic content and peroxidase (POD) activity showed enhancement with increasing lithium concentration. Our data analysis strongly suggests dose-dependent toxicity in young seedlings under in vitro conditions. These findings shed light on the potential ecological implications of lithium leaching from retired batteries.
Impact of feed on the yield of Litopenaeus vannamei and Macrobrachium rosenbergii prawn culture from West Godavari district, Andhra Pradesh, India
Authors: Sravanthi B. , Lalitha Ch. , Lakshmi V.
Published: December 2023

Aquaculture, a vital sector addressing global food demand, is characterized by its extensive water requirements. Categorized into mariculture, freshwater aquaculture, and brackish water aquaculture, the sector plays a crucial role in food production. This study focuses on prawn cultivation, a significant aspect of aquaculture, emphasizing the influence of feed quality and hydrographic parameters on yield and ecological sustainability. Conducted in Vissakoderu village (Litopenaeus vannamei) and Eduru village (Macrobrachium rosenbergii), the research employed commercial feed, optimizing physicochemical parameters such as temperature, pH, and salinity. Probiotics were integrated into the feed to enhance prawn growth. Results indicated optimal levels of moisture, lipids, protein, fiber, carbohydrates, minerals, and vitamins in the feed. The progressive weight gain of prawns, reaching 30.00 kg for 1000 prawns, was correlated with an increased feeding frequency. Scientifically monitored hydrographic conditions and feed quality contributed to a remarkable average yield of 29 tons for Litopenaeus vannamei and 63.33 tons for Macrobrachium rosenbergii over three years. This underscores the importance of precision in aquaculture practices for both yield enhancement and ecological preservation. The study provides valuable insights into the sensitivity of prawn cultivation, emphasizing the need for meticulous care in managing hydrographical, feed, and disease parameters.
The grain production of blue lupine affected by the growth of nodule bacteria
Authors: Ястребова А.В. , Рябова Т.Н. , Коконов С.И.
Published: December 2023

Исследование проведены в 2020–2022 годах на опытном поле учебно-научно-производственного комплекса «Агротехнопарк» Удмуртского ГАУ. Целью работы была оценка эффективности предпосевной обработки семян в формировании агроценозов люпина узколистного. Высевали люпин узколистный сорта Ладный. Семена перед посевом обрабатывали инокулянтом «Ризоторфин» (Rhizobium lupine) (1 л/т), регулятором роста растений «Мелафен» (5 мл/т), комплексным удобрением Agree’s Форсаж (2 л/т), фунгицидом «Максим XL» (0,4 л/т), комплексным удобрением Agree’s Форсаж совместно с регулятором роста растений «Мелафен», фунгицидом «Максим XL» совместно с регулятором роста растений «Мелафен», фунгицидом «Максим XL» совместно с комплексным удобрением Agree’s Форсаж. В качестве контроля был взят вариант без обработки. На основании полученных экспериментальных данных выявлено положительное влияние предпосевной обработки семян, которую можно рекомендовать сельскохозяйственному производству для повышения продуктивности люпина узколистного. В среднем за 3 года исследований обработка семян люпина узколистного пред посевом инокулянтом, комплексным удобрением и комплексным удобрением с регулятором роста растений способствовала формированию на корнях 925,4–1090,4 шт./м2 клубеньковых бактерий, что на 472,9–637,9 шт./м2, или на 104–141%, больше, чем при посеве необработанными семенами. Наибольшая урожайность люпина узколистного (1,54–1,62 т/га) получена при применении для предпосевной обработки семян комплексного удобрения Agree’s Форсаж и его совместном использовании с регулятором роста растений «Мелафен» и фунгицидом «Максим XL» за счёт развития клубеньковых бактерий, о чём свидетельствует прямая средняя корреляция r = 0,58.

This investigation took place at the “Agrotechnopark”, Research and Production Complex of the Udmurt State Agrarian University. The aim of this research was to test the effectiveness of seed treatment in the sward formation of Ladnyy, blue lupine. Seeds were treated by “Rizotorfin” (Rhizobium lupine) (1 l/t), “Melafen”, plant growth regulator (5 ml/t), Agree’s Forsazh, complex fertilizer (2 l/t), “Maksim XL”, fungicide (0.4 l/t), the combinations of Agree’s Forsazh and “Melafen”, “Maksim XL” and “Melafen”, “Maksim XL” and Agree’s Forsazh. The untreated variant was used as a control. The seed treatment positively affected the productivity of blue lupine. The seed treatment with “Rizotorfin”, Agree’s Forsazh as well as the combination of Agree’s Forsazh with “Melafen” led to the formation of 925.4–1090.4 pcs/m2 of nodule bacteria exceeding the control by 472.9–637.9 pcs/m2, or 104–141%. The highest productivity of blue lupine (1.54–1.62 t ha-1) happened after the seed treatment by Agree’s Forsazh, “Melafen” and “Maksim XL” due to the growth of nodule bacteria (r = 0.58).
The Influence of Model Building Schemes and Molecular Dynamics Sampling on QM-cluster Models: The Chorismate Mutase Case Study
Authors: Agbaglo Donatus Atsu , Summers Thomas , Cheng Qianyi , DeYonker Nathan
Published: December 2023

Most QM-cluster models of enzymes are constructed based on X-ray crystal structures, which limits comparison to in vivo structure and mechanism. The active site of chorismate mutase from Bacillus subtilis and the enzymatic transformation of chorismate to prephenate is used as a case study to guide construction of QM-cluster models built first from the X-ray crystal structure, then from molecular dynamics (MD) simulation snapshots. The Residue Interaction Network-based ResidUe Selector (RINRUS) software toolkit, developed by our group to simplify and automate the construction of QM-cluster models, is expanded to handle MD to QM-cluster model workflows. Several options, some employing novel topological clustering from Residue Interaction Network (RIN) information, are evaluated for generating conformational clustering from MD simulation. RINRUS then generates a statistical thermodynamic framework for QM-cluster modeling of the chorismate mutase mechanism via refining 250 MD frames with Density Functional Theory (DFT). The 250 QM-cluster models sampled provide a mean ∆G‡ of 10.3 ± 2.6 kcal mol-1 compared to the experimental value of 15.4 kcal mol-1 at 25 0C. While the difference between theory and experiment is consequential, the level of theory used is modest and therefore “chemical” accuracy is unexpected. More important are the comparisons made between QM-cluster models designed from the X-ray crystal structure versus those from MD frames. The large variations in kinetic and thermodynamic properties arise from geometric changes in the ensemble of QM-cluster models, rather from the composition of the QM-cluster models or from the active site-solvent interface. The findings open the way for further quantitative and reproducible calibration in the field of computational enzymology using the model construction framework afforded with the RINRUS software toolkit.