bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends of Breastfeeding Practice and Determinant Factors of Exclusive Breastfeeding in Bangladesh: Evidence from the Six Nationally Representative Cross-Sectional Surveys
Authors: Md Awal Kabir  , Md Jahidul Islam
Published: May 2022

Poor breastfeeding is found to be responsiable for child adverse health and development problems. The aims of this study are to examine the trend of World Health Organization’s (WHOs) recommended breastfeeding practices and determinant factors of exclusive breastfeeding (EBP). Data were extracted from six nationally representative Bangladesh Demographic and Health Survey (BDHSs). The WHO recommended indicators related to the breastfeeding practices were calculated. Multivariate logistic regression model was used to identify the factors associated with EBP with accounting complex survey design. Among the four indicators of breastfeeding practices, increasing trend was reported only for early initiation of breastfeeding among the surveys years. Multivariate logistic model explored mothers’ age, occupation, place of delivery, number of antenatal visits were most important predictors of EBP in almost all of the survey year. Number of children ever born and economic condition was found to be associated with EBP only for the surveys conducted in 2004, 2007, and 2011. Poor breastfeeding practices adherence to WHO guidelines indicate the immediate attention of the policy makers to take policies and programs to enhance breastfeeding practices in Bangladesh. Higher aged maternal women, higher socio-economic status, and currently working mothers should be given priority in future policies and programs.
Phytochemical Screening and Antimicrobial Assay of Selected Plant Extracts with Ethnopharmacological Potential for Wound Healing
Authors: Cano Junar , Pescuela Joey , Antesa Dorothy , Mortejo Vinge Lyssa , Aguirre Chrisabelle , Gallardo Sophia Alyannah
Published: May 2022

Bacteria usually colonize wounds, and their low level is beneficial to the wound healing process. Thus, antibacterial agents are usually applied to wounds. In the Philippines, many herbal plants are used to speed up the wound healing process. With their number, literature revealed no scientific study yet on which among these plants could well inhibit wound bacteria. Hence, this study focused on the phytochemical screening and antibacterial activity of the ethanolic extracts of six herbal plants, namely: Caesalpinia sappan Linn. (Sibukao), Jatropha curcas Linn. (Tuba-tuba), Lantana camara Linn. (Kantutay), Mimosa pudica Linn. (Makahiya), Moringa oleifera Lam. (Malunggay), and Psidium guajava Linn. (Guava). Betadine was used as the positive control. Qualitative phytochemical analysis and antimicrobial assay on wound bacteria using the agar well diffusion method were employed from the six extracts. Results revealed that phytochemicals, namely alkaloids, saponins, flavonoids, and tannins, were present in the plant extracts except for anthraquinones. Furthermore, the plant extracts showed antibacterial activity on wound bacteria, and P. guajava leaf extract exhibited the most significant antibacterial effect among the treatments and is greater than the positive control (Betadine solution). On the other hand, all the plant extracts have a lower antibiotic activity index when compared with Amikacin 30mcg and Erythromycin 15 mcg. However, except for Lantana camara extract, the five plant extracts have a remarkably higher antibiotic activity index when compared with Penicillin 10 U. It is concluded that the plants studied have varying levels of antibacterial activities that could promote wound healing.
Funding Analysis, Company Cash Flow Statement and Its Effect on Banking Firm Value
Authors: Kustinah Siti
Published: May 2022

This study aimed to analyze the effect of funding and cash flow statements on firm value. This research uses quantitative research with an associative approach. The type of data used is primary data and secondary data. This research was conducted on ten expert accountants using questionnaires and Likert scale calculations. Data were collected by questionnaire method and literature study. The source of the data used in this study comes from the BBCA's financial statements for the 2017-2020 period, which have been audited and obtained from IDX and the results of questionnaires to expert respondents—testing the data using validity test, reliability test, and hypothesis testing. The research findings indicate that Funding and Cash Flow Statements have a direct, positive, and significant effect on firm value.
Kashmir in India-Pakistan Relations: Perspective Pakistan’s Nuclear Policy, Background and Development Towards Conflict Resolution
Authors: Khurshad Taimor
Published: May 2022

The conflict between India and Pakistan over the Kashmir problem still seems to be an obstacle in their relations. It has been 58 years since the dispute has passed, but there is no final agreement that can be accepted by both parties. If 1947 is the day of independence for India and Pakistan, then that year is the beginning of the suffering of the people of Kashmir. Pakistan as the party that has the right to make Kashmir as part of its territory feels the need to continue to raise this issue even though it has to develop nuclear though.
Collaborative Governance in Renewable Energy Utilization
Authors: Achmad  , Djaenuri Aries , Supriyatna Tjahya , Hamdi Muchlis
Published: May 2022

This study aims to analyze collaborative governance between the Regional Government and the State Electricity Company and the Biogas Power Plant in utilizing renewable energy in Rantau Sakti Village, North Tambusai District, Rokan Hulu Regency, Riau Province, Indonesia. This research was conducted using qualitative methods. Data collection techniques used in this study were interviews, observation and documentation study. Collaboration between the Regional Government and the State Electricity Company and the Biogas Power Plant in utilizing new and renewable energy has not yet been formed in a whole and comprehensive manner. If the Biogas Power Plant already has legality and clarity on the legal status and its management as a result of a change in the Regional Government Law which causes the authority in the energy sector to be drawn to the provincial level, the Regional Government of Rokan Hulu Regency loses management rights over the Power Plant Biogas.
Values in China's Economic Diplomation
Authors: Muhammad Arshid
Published: May 2022

Rapid economic developments over the recent decades has made China to be the center of many researches. China has been known of having a unique technique of diplomacy. How a group of people interact with each other is strongly influenced by the values that has been developed in the social order. This paper uses research methods that focuses on literature reviews of books and articles that will explore the kind of values developed and is considered important and influential in the local society of China. This paper will also suggest techniques directly to China's economic diplomacy undertaken by both countries, individuals, or through joint venture
Implementation of Verbal Linguistics Analysis Development in Ecolexicon and Ecoteks at Bale Sangkep, Green School Bali
Authors: Widanti Ni Putu Tirka
Published: May 2022

Ecolinguistics examines the whole nature of the relationship between language and the environment which is an expression of the entire reality of human life. GSB is an educational environment that preserves nature with the concept of local wisdom with a natural perspective. Lexicons derived from local, national and global languages are widely used in naming buildings, academic activities, aned daily activities. This study aims to describe the ecolexicon and ecotext found in the bale sangkep in GSB. There are 2 research focuses, first, to describe the form, meaning, and grammatical categories of the ecolexicon; second, to describe the tridimensional ecotext social praxis found in the bale sangkep in GSB. The research was conducted with a descriptive approach with qualitative methods. Data collection is done through observation, documentation, and interview methods. The data were analyzed by applying the identity method and the distributional method. The results of the study show that there are 89 lexicons related to the bale sangkep GSB. Lexicons are identified based on grammatical categories, meanings, and the existence of their environment. The total lexicons found are 69 lexicon are categorized as nouns which is consists of 19 nouns in the form of basic words, 3 nouns in the form of derivatives, 1 noun which is a compound word, and 46 other noun lexicon in the form of noun phrases. Meanwhile, the other 20 lexicons are lexicons categorized as verbs, where 1 lexicon is a basic verb and 19 lexicon is a derivative verb. The tridimensional of the ecotext are viewed from: the biological dimension, the speaker’s understanding of the physical entity of the lexicon; sociological dimension, the closeness of speakers through the use and way of implementing the lexicon entity; and ideological dimensions, collective relations, cognitive and psychological systems of speakers in the form of beliefs and beliefs about lexicon references. It can be concluded that this study reveals the richness of the lexicon in GSB as supporting data for ecolinguistics.
PENGEMBANGAN PROTOTIPE APLIKASI MEMBUKA KUNCI PINTU OTOMATIS MENGGUNAKAN METODE SIDIK JARI BERBASIS NODEMCU
Authors: Hady Fahrur , Sholeh Muhamamd , Andayati Dina
Published: May 2022

In the current digitalization era, the use of household appliances has been developed using information technology such as the process of using devices using passwords, cards, fingerprints and the like. Likewise, the process of opening doors which is done manually, in the era of digitization can also be developed based on information technology. In this study, a prototype application was developed that could open the door device automatically using a smartphone. The research methodology is carried out by studying literature as a reference for research to be made, observations on software and hardware as well as simulation of hardware and software. The software made in the form of an android application that can detect fingerprints to be able to log into the system and the process of storing usage records with firebase. The hardware uses NodeMCU as a microcontroller board, relay as a current regulator which will be forwarded to the door lock solenoid. The result of the research is an application prototype that can open the door automatically. The process of using the application is done by first logging in using a fingerprint. The application can send commands to open and lock the door automatically. The microcontroller device can realize the command to open and lock the door by activating the solenoid door lock which is set through the NodeMCU and is connected wirelessly via the internet network. Applications can also log all application usage activities. All application usage records are stored in a database. Authority processes in application usage are divided into admin level and user level. At the admin level, admins can view system usage records as well as add, view, modify and delete user data. At the user level, the application is limited to only sending commands in the form of opening and locking doors.
PENGENALAN AKTIFITAS CYBER THREAT HUNTING : STUDI KASUS HUNTING MALWARE DENGAN METODE MEMORY FORENSIC
Authors: Nursyahiddin Fadillah , Zulfa Oktaviani Siti , Dwi Iklima Lutvita , Nurdiyanti Feby
Published: May 2022

Cyber Threat Hunting adalah salah satu aktivitas pada lingkup keamanan siber yang sedang berkembang pada saat ini. Threat Hunting menunjukan proses pencarian kerentanan serta aktor kejahatan siber yang kemungkinan sudah berada di dalam system maupun rencana kemungkinan seragan yang akan terjadi di waktu yang akan datang secara proaktif melalui media jarigan untuk mengantisipasi adanya insiden keamanan siber yang akan terjadi pada suatu infrastruktur terkait. tentu dengan adanya threat hunting ini akan melengkapi kegiatan passive monitoring yang hanya mengandalkan alert pada SIEM ( Security Information and Event Management ), dan studi kasus yang akan saya angkat adalah metode threat hunting pada low level memory sehingga apabila ada aktor kejahatan siber yang lolos pada sistem SIEM dan berkemungkinan sudah berada pada sistem internal dapat terdeteksi dan dapat melakukan kegiatan forensik dan pemulihan sistem terkait.
PERANCANGAN SISTEM INFORMASI ABSENSI KEHADIRAN SISWA BERBASIS WEB PADA SMK MUHAMMADIYAH 3 KLATEN UTARA
Authors: Yuliana Nurma , Suradi Agustinus , Kurniawan Hidayat Syams , Joko Prasetyo Hendro
Published: May 2022

SMK Muhammadiyah 3 Klaten Utara is one of the private schools whose attendance media still uses an attendance manual or handwriting. By using handwritten attendance media, sometimes the stored data is damaged and easily lost so that attendance recapitulation takes a long time. The lack of communication and information between the school and parents resulted in students being able to report that they were in learning activities but in fact the students were playing with friends. So we need a web-based information system that is connected to a network using an SMS Gateway that can be directly connected to parents to control their children going to school or not. Web-Based Student Attendance Attendance Information System Design at Smk Muhammadiyah 3 Klaten Utara aims to help solve these problems. This information system will be able to manage student data, department data, class data, user data, input attendance data, sms and reports that can recapitulate attendance data. The method in designing this information system uses the waterfall model, using the method of observation and interviews at the time the research was conducted.

Applications designed and designed using the Unified Modeling Language (UML), and built using a web-based application using the PHP (Hypertext Preprocessor) programming language, and also equipped with a database designed using MySQL and Modem and Gammu as a tool for sending messages. With this application, you can find out the activities of students who are present at school
ALAT PENGONTROL PERANGKAT ELEKTRONIK BERBASIS IOT MENGGUNAKAN BLYNK DAN GOOGLE ASSISTANT
Authors: Mulyana Azril , Rahmawati Sri , Rahman Robby , Nur Permatasari Zulia
Published: May 2022

Perkembangan teknologi yang semakin pesat berpengaruh terhadap dunia industry maupun masyarakat. Di kehidupan sehari-hari, kita akrab dengan sebuah perangkat atau peralatan yang cara kerjanya dikendalikan otomatis, baik semi otomatis maupun full otomatis. Di era industry 4.0 ini, banyak sekali perangkat elektronik yang berfungsi secara otomatis menggunakan sistem komputer. Salah satunya adalah pemanfaatan teknologi untuk pengembangan rumah pintar (smarthome). Dengan adanya inovasi tersebut, pengoperasian dan penggunaan perangkat listrik akan menjadi sangat mudah, sehingga pekerjaan manusia akan terbantu. Penggunaan teknologi Internet of Things (IoT) pada sebuah perangkat elektronik, memungkinkan perangkat tersebut untuk berkomunikasi satu sama lain, mengirim dan menerima data melalui koneksi Internet.

Tujuan dalam penelitian ini adalah untuk mengendalikan peralatan elektronik, seperti lampu dan kipas, agar pemilik rumah dapat mengontrol perangkat tersebut dari jarak jauh. Tahapan-tahapan yang dilakukan dalam penelitian yaitu pertama, tahap penentuan Software dan Hardware, perancangan system, dan tahapan terakhir yeitu pengujian dan pembahasan. Dalam penelitian ini, dibutuhkan sebuah mikrokontroller yaitu NodeMcu, yang berfungsi untuk mengendalikan perangkat listrik, mengolah data, mengirim dan menerima data ke server Blynk. Cara kerja system ini adalah dengan mengeluarkan perintah atau ketentuan dari aplikasi Google Assistant dan aplikasi Blynk yang terhubung ke mikrokontroler mandiri NodeMCU ESP8266 untuk menjalankan dan mengontrol perangkat SmartHome untuk mengurangi daya yang terbuang ketika pengguna lupa mematikan Smart Home di perangkat Android.
SISTEM PAKAR PENDIAGNOSA PENYAKIT DIABETES MELITUS MENGGUNAKAN FORWARD CHAINING
Authors: Trisnawati Depi , Windarti Mariana , Sulistyowati Istri , Budi Hartono Fajar
Published: May 2022

Penyakit diabetes merupakan penyakit penyebab kematian yang cukup tinggi didunia bahkan di Indonesia, hal ini ditunjukkan dengan posisi Indonesia dengan jumlah pasien diabetes tertinggi berada pada urutan ke-7 dari 10 negara. Diabetes Melitus  juga merupakan penyakit menahun yang menjadi problem kesehatan masyarakat di Indonesia. Hingga tahun 2020 jumlah serangan diabetes mencapai 18 juta. Penggunaan teknologi komputer yang semakin meningkat menyebabkan cepatnya arus informasi dan komunikasi antara satu tempat ketempat lain. Salah satu penerapan teknologi adalah sistem pakar. Melalui sistem pakar pasien dapat mengetahui jenis penyakit yang dideritanya berdasarkan gejala-gejala yang ditimbulkan tanpa harus ke dokter. Pada penelitian ini akan dirancang sistem pakar untuk mendiagnosa penyakit diabetes mellitus menggunakan metode inferensi forward chaining  dan perangkat lunak Microsoft Visual FoxPro 9.0. Metode forward chaining bekerja dengan menganalisa fakta-fakta yang diperoleh dari inputan berdasarkan rule yang tersimpan dalam database untuk mendapatkan sebuah kesimpulan. Sistem pakar untuk mendiagnosa penyakit diabetes mellitus ini dapat digunakan sebagai alat bantu bagi masyarakat tanpa harus konsultasi langsung ke dokter. Kesimpulan atau solusi yang diperoleh dari sistem pakar ini adalah pengguna diprediksi terkena penyakit diabetes atau tidak mengalami diabetes ringan atau susulan beserta hasil diagnose sesuai dengan solusi yang diberikan sistem
PERANCANGAN SISTEM INFORMASI ABSENSI KEHADIRAN SISWA BERBASIS WEB PADA SMK MUHAMMADIYAH 3 KLATEN UTARA
Authors: Yuliana Nurma , Suradi Agustinus , Kurniawan Hidayat Syams , Joko Prasetyo Hendro
Published: May 2022

SMK Muhammadiyah 3 Klaten Utara adalah salah satu sekolah swasta yang media absensinya masih menggunakan absensi manual atau tulis tangan.  Dengan menggunakan media absensi tulis tangan, terkadang data yang disimpan mudah hilang sehingga rekapitulasi absensi memerlukan waktu yang cukup lama. Kurang berjalannya komunikasi dan informasi antara pihak sekolah dan orang tua mengakibatkan siswa dapat berbohong dengan melaporkan bahwa sedang dalam kegiatan belajar namun kenyataanya siswa tersebut sedang bermain dengan temannya. Maka dibutuhkan suatu sistem informasi berbasis web yang terhubung ke suatu jaringan menggunakan SMS Gateway yang dapat terhubung langsung dengan orang tua untuk mengontrol anaknya masuk atau tidak.

Perancangan Sistem Informasi Absensi Kehadiran Siswa Berbasis Web Pada Smk Muhammadiyah 3 Klaten Utara bertujuan untuk membantu menyelesaikan permasalahan tersebut. Seperti sistem yang dapat mengelola data siswa, data jurusan, data kelas, data user, input data absensi, sms serta laporan yang dapat merekapitulasi data absensi. Metode yang digunakan pada aplikasi ini menggunakan metode Software Development Life Cycle (SDLC) yaitu metode waterfall mulai dari perencanaan, analisis, desain, hasil penelitian dan pembahasan serta menggunakan metode observasi dan wawancara

Aplikasi didisain dan dirancang menggunakan Unified Modeling Language (UML), dan dibangun menggunakan aplikasi berbasis web menggunakan bahasa pemrograman PHP (Hypertext Preprocessor), dan juga dilengkapi dengan database yang didesain menggunakan MySQL serta Modem dan Gammu sebagai alat untuk mengirimkan pesan. Dengan adanya aplikasi ini, dapat mengetahui aktivitas siswa yang hadir disekolah.
ANALISIS PENGAWASAN PETUGAS AVIATION SECURITY (AVSEC) DALAM MENDETEKSI BAHAN PELEDAK DI BANDAR UDARA KOMODO LABUAN BAJO
Authors: Asri  , Frisnawati Elnia
Published: May 2022

Aviation Security (AVSEC) officer still frequently discover dangerous goods in passenger luggage, such as scissors, knives, small gas cylinders, machetes/swords, razors, gas lighters, cutlery, a power bank that exceeds the limit, sea shells, pink sand, and marine life in the Prohibited Item category. Researchers also discovered that many passengers were bringing alcoholic beverages that were not labeled and exceeded the specified standards. This research aims 1) To discover how Aviation Security (AVSEC) officers play a part to aviation security and safety at Komodo Labuan Bajo Airport. 2) To determine what equipment is required to support Security Check Point (SCP) two in maintaining aviation security and safety at Komodo Labuan Bajo Airport. 3) To find out how Komodo Labuan Bajo Airport Aviation Security (AVSEC) officers handle dangerous explosive materials. This research uses qualitative methods. Data collection is carried out by observation methods, interviews, and documentation which are then carried out data analysis using data reduction, data presentation and conclusions. The results of this study reveal that 1) Aviation Security Officers (AVSEC) have a very important role in ensuring flight security and safety, 2) Passenger inspections on SCP 2 are carried out Security checks on SCP 2 must be supported by inspections with flight security aids, where inspections This is done by using X-Ray machine tools, Walk Through Metal Detector (WTMD), and Hand Hel Metal Detector (HHMD), 3) Aviation Security Officers (AVSEC) in handling explosives that are considered dangerous to all parties must carry out regular inspections. strict restrictions on passengers and goods that enter the area at Komodo Labuan Bajo Airport to prevent the transportation of prohibited and dangerous goods and can be used to threaten safety and security.
Trends in the Development of the Right to Information in the Context of Digitalization
Authors: Tereshchenko L.K.
Published: May 2022

Статья посвящена анализу существующих векторов развития права на доступ к информации в условиях цифровизации. Методологической основой работы являются общенаучные и специальные методы научного познания: диалектический метод, формально-логический метод, включающий в себя анализ и синтез, индукцию и дедукцию, абстрагирование и обобщение, а также специальные методы, в том числе формально-юридический метод. Результаты. Были выявлены два разнонаправленных вектора развития права на доступ к информации: вектор на расширение права на доступ к информации и вектор на ограничение доступа. Показаны факторы, способствующие расширению права на доступ к информации. Другим вектором является расширение объема запрещенной информации и информации ограниченного доступа. Показаны факторы, способствующие ограничению доступа к определенной информации.
Eco-friendly synthesis, biological evaluation and QSAR studies of dihydropyrimidinone/thione derivatives
Authors: Choudhary Alka N , Kumar Arun , Sharma Neetu , Ghai Kapil
Published: May 2022

Dihydropyrimidinone/thiones (DHPMs) hold earmarked place in the field of natural and synthetic organic chemistry, because of their therapeutic and pharmacological properties. Synthesis of such biologically important compounds assumes great concern. Objectives The aim of the present work was to synthesize structurally challenging DHPMs through green procedure, evaluated for antibacterial activity and to perform QSAR analysis to attain the structural requirements for the antibacterial activity. The synthesis of dihydropyrimidinone/thiones was accomplished via three-component one-pot cyclocondensation between substituted alkyl/aryl aldehydes, diketone and urea/thiourea in the presence of pine apple juice at room temperature. The structures of the compounds were established by spectral analysis and evaluated for antibacterial activity. Possible correlation between observed biological activity and physicochemical descriptors was studied. Synthesis of DHPMs by pineapple juice as a catalyst, complies with principle of green chemistry. Moreover, this solvent free approach totally offers nonpolluting environment and avoiding the usage of toxic organic solvents. The spectral analysis reveals that all the compounds 1a-1p was in good agreement with the standard values reported in the literature for these types of structures. The tested compounds 1e, 1m &1i, 1o showed maximum activity against S. aureus and E. coli at concentrations i.e250 & 500μg /ml respectively. The statistically significant equations with good coefficient of correlation were obtained by correlating antibacterial activities as dependent variables and substituent constants as independent variable. The result of the QSAR study suggested that steric and thermodynamic descriptors contributed significantly to biological activity. Green synthesis of dihydropyrimidinone/thiones is extremely useful and improved procedure for the Biginelli reaction with excellent yields in shorter reaction time with high purity of the products. Through the iterative computational approach, this study could be utilized to design more potent dihydropyrimidinone/thione analogues as antimicrobial agents. Keywords: Green Synthesis, Dihydropyrimidinone/thioneanalogues, Anti-bacterial.
Analytical method development and validation of Miconazole and neomycin by Simultaneous estimation method
Authors: Pawar Neelam , Jalwal Pawan , Bahmani Kavita
Published: May 2022

An innovative, straightforward, precise, accurate, reproducible, and efficient simultaneous equation method, or Vierordt's technique, was successfully developed for predicting Miconazole and Neomycin in pharmaceutical Non-Pressurized Topical spray. Miconazole and Neomycin absorbance in 6.8 pH phosphate buffer and in ethanol were established at two wavelengths of 246 nm and 224 nm, respectively. Miconazole and Neomycin spectrum of standard curve showed to be linear in concentrations of 5-12 μg/ml and 2-10 μg/ml, respectively, with correlation coefficients of 0.9988. The LOD along with LOQ for Miconazole were 0.59 μg/ml and 7.385 μg/ml, significantly, whereas the LOD and LOQ for Neomycin were 0.28 μg/ml and 1.493 μg/ml. The precision investigation examined at the percent relative standard deviation, values were confirmed to be within allowable limits. At various levels, the percentage rate of recovery for Miconazole ranged from 0.12 to 0.47 percent and 0.23 to 0.31 percent for Neomycin, indicating that the suggested approach is accurate. Basis of the findings of this experiment, it can be concluded that detecting Miconazole and Neomycin in the non-pressurized topical spray. Simultaneously is simple, accurate, precise as well as economical. The proposed approach might be brought to calculate Miconazole and Neomycin in non-pressurized topical spray form. Keywords: Miconazole, Neomycin, Simultaneous Estimation, Validation.
Infectious bursal disease: Overview
Authors: Kapoor Sanchita , Kaur Harmanpreet , Rehman Aqueel Ur , Kumar Vijay , , Gupta Amit
Published: May 2022

In recent years, many infectious veterinary diseases have caused massive losses in India's poultry population. These illnesses have a substantial impact on mortality, morbidity, and case fatality rates, resulting in large economic losses, as well as decreased productivity in the chicken industry. Infectious bursal disease (IBD) is sometimes called Gumboro disease. It is regarded as a highly infectious and epidemic disease that mainly spreads among poultry, turkeys, and wild birds through a virus. IBD is considered in the top 5 infectious diseases affecting chickens and birds which is a huge global threat and has caused many economic losses and welfare concerns. Direct impact on mortality from 3% to 30�pends upon the degree of protection of the birds and the form of the disease. The present review discusses about structure, serotypes, hosts & route and diagnosis of IBD and also collects information regarding surveillance and genomic analysis of IBD. Keywords: IBD, viral disease, epidemic, birds.
Development and validation of methodology to study the genetic polymorphism of organic cation transporter 1 (OCT1) - rs622342: A Prospective open-label study
Authors: Borra Swathi Swaroopa , Choorapra Diya , Nair Gopika , Chithra Hemachandran , Mani Jegathis Kumar , Krishnamoorthy Sadagoban Gopal , Parthasarathy Arun Kanniyappan
Published: May 2022

The main objective is to develop and validate the methodology to study the genetic polymorphism of Organic cation transporter (OCT1) rs622342. The Reverse Transcriptase-PCR method for identifying the OCT1 rs622342 genetic polymorphism was developed and validated. This study is a prospective open-label study conducted over a period of six months with 61 South Indian healthy male volunteers. Phenol chloroform method was used for the DNA isolation, which was subjected to PCR for identifying the polymorphism. The method was successfully developed. After the addition of restriction enzyme (PsiI) in the ten samples, none of the samples showed fragmentation, which shows that there is a lack of rs622342 genetic polymorphism in the selected ten samples. Keywords: Genetic polymorphism, Organic cation transporter, Methodology & Validation, Healthy volunteers.
Design, synthesis, anti-infective and anti-cancer potential of thiazole based Pyrazoles bearing benzothiazole moiety
Authors: Sharma Diksha , Sharma Archana , Pahwa Rakesh , Chand Rana Avtar , Sharma Prabodh Chander
Published: May 2022

A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL) than standard drugs. Compounds 5a and 5e were reported to be most active antimalarial analogue having IC50 value of 0.24-0.49μg/mL. Compounds 5a, 5e and 5f showed shortest mean paralysis time of (25.6±4.56 min, 26.4±4.97 min and 26.8±4.76 min) and mean death time (47.6±8.01min, 45.6±3.04min and 46.6±7.40min), respectively. Compound 5e showed moderate cytotoxicity with IC50 value of 65.4 against MCF-7. The results proved that 1,3-thiazolyl-pyrazole clubbed benzothiazole derivatives showed considerable antiinfective and cytotoxic activity. Keywords: Anti-infective activity, Cytotoxic activity, Spectroscopic methods, Thiazole, Pyrazole, Benzothiazole.
Immunohistochemical expression of epidermal growth factor receptor (EGFR) and p53 in Gliomas and correlation with clinicopathological parameters
Authors: Das Prajna , Mohapatra Debahuti , Sumedha Dash Sushree , Mohanty Pranita
Published: May 2022

The most common primary central nervous system (CNS) tumor originating from glial cells is Glioma. It accounts for approximately 80% of all primary malignant brain tumors. Our aim was to study the expressionof Epidermal Growth Factor Receptors (EGFR) and p53 by Immunohistochemistry (IHC) in Gliomas and to correlate with various histological types and grades as well as clinical parameters like age and gender of patients. It was an ambispective study for 1year and 2 months conducted in IMS Sum Hospital, Bhubaneswar. 38 cases of Gliomas operated in Neurosurgery Department were studied. Histological typing & grading were done according to WHO 2016 classification of CNS tumors. EGFR & p53 study was done by immunohistochemistry (IHC).Out of 38 cases, 14 cases (36.8%), 6 cases (15.7%), 6 cases (15.7%), 4 cases (10.5%), 6 cases (15.7%) and 2 cases (5.2%) were Astrocytoma, Oligodendroglioma, Glioblastoma, GBM with oligodendroglioma, Gliosarcoma and Ependymoma respectively. 2 cases (5.2%), 14 cases (36.8%), 6 cases (15.7%) and 16 cases (42.1%) were of Grade- I, II, III and IV respectively. In Grade I tumors, there was negative expression of both EGFR and p53. EGFR and p53 was positive in 57.14%, 71.42�ses of Grade II tumors respectively. Both the markers were 100% positive in Grade III and Grade IV tumors. Thus, there was positive and negative correlation with expression of both EGFR & p53 in higher grades low grades of tumors. Keywords: EGFR, Glioblastoma (GBM), p53, Immunohistochemical analysis, Clinical parameters.
Evaluation of health seeking behaviour of patients with severe periodontitis visiting private dental college and hospital
Authors: Naqvi Dr Akbar , Das H Dr Aruna , Parthi Dr. Aiyana , Kamra Dr Mohit , G Nagrale Dr Renuka , Kumar Dr Prabhakar , Gaurav Chhabra Dr Kumar
Published: May 2022

Severe periodontal disease, which may result in tooth loss, was estimated to be the 11th most prevalent disease globally. Despite such high prevalence awareness regarding it is still very little. Understanding of health seeking behaviour is essential to provide need based health care services to the population and managing periodontal diseases. Hence the present research was carried out to identify the determinants of health seeking behaviour in patients visiting private dental college and hospital with severe periodontitis. A cross sectional study was conducted among the patients visiting private dental colleges and hospitals with severe periodontitis between the age group of 18 and above. Data was recorded by a self- administered, structured, pre-tested questionnaire based on items to determine health seeking behaviour of participants in this study. Study included 512 participants, 279 (54.5%) males and 233 (45.5%) females. It was observed that mobile tooth was the most common dental problem reported by 288 (56.3%) participants. Fear was the major reason for not visiting the dentist and constituted about 57 (33.7%) of the total influencing factors. It can be concluded that healthcare seeking behaviour among sever periodontitis patients was poor. So efforts must be made to bring a change in this scenario. Keywords: Severe periodontitis, Response rate, Quality healthcare, Socioeconomic Status, Chronic disease prevention programmes.
Biological studies of Schiff base, 2-(1-hydroxycyclohexyl) phenyl methylene hydrazine carbothioamide and its Cu(II) and Zn(II) metal complexes
Authors: Kamatam Prasuna M , Sanambatla Vanitha , Kalluru Seshaiah
Published: May 2022

Condensation of 1-hydroxycyclohexyl phenyl ketone with hydrazine carbothioamide produced a new Schiff base, 2-(1-hydroxycyclohexyl) phenyl methylene hydrazine carbothioamide. The Cu(II) and Zn(II) metal complexes of the Schiff base were prepared. The different spectroscopic methods such as FT-IR, UV-Visible, 1H NMR, and 13C NMR spectroscopy were used to elucidate the structural characteristics of the synthesized compounds. Further, the biological applications of the prepared Schiff bases and its metal complexes were studied for the antibacterial activity. The antimicrobial investigation was carried out against different Gram positive and Gram negative bacteria like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. According to the findings, the prepared Cu(II) and Zn(II) metal complexes are more biologically active than Schiff base ligand, and among all tested bacterial species, Staphylococcus aureus growth was most inhibited by prepared compounds. Keywords: 1-hydroxycyclohexyl phenyl ketone, Hydrazine carbothioamide, Schiff base, Cu (II), Zn (II)
Multivariate UV spectrophotometric quantification of Cilnidipine in bulk drug and pharmaceutical formulations
Authors: Ravi Vimal , KS Kokilambigai , J Kavitha , R Seetharaman , KS Lakshmi
Published: May 2022

The aim of this research work was to develop a simple, accurate, sensitive and validated Ultra Violet (UV) spectrophotometric assay using the multivariate regression method for the analysis of Cilnidipine. This multivariate calibration technique was based on equations constructed using linear regression analysis using the correlation between absorbance and concentration at five selected equidistant wavelengths. Cilnidipine had a maximum absorbance at 240 nm. The findings were statistically analyzed for significance. A linear plot in the concentration range of 3-9 μg/mL, with a regression coefficient of 0.999 was obtained. The % RSD for intra-day and Inter-day precision were 0.4558 and 0.6099, respectively. The assay was determined and found to be 99.1% - 101.67% % w/w. Keywords: Cilnidipine, Antihypertensive agent, UV spectrophotometry, Multivariate calibration, Assay, ICH guidelines).
Evaluation of water quality for drinking purpose from various zones of southern part of tamilnadu, chennai, india
Authors: Pradeep R , Arun K , Venkatesan S , Kathiravan MK , Srimathi* R
Published: May 2022

The objective of this study was to assess the drinking water quality from North, Central, South, and West regions of Chennai. The samples for analysis included metro water, ground water, Reverse Osmosis water, packaged drinking water, mineral water, boiled water, and rainwater. Analysis of sixteen physicochemical parameters such as pH, turbidity, Electrical conductivity, Total dissolved solids, Total suspended solids, major cations like calcium (Ca2+), sodium (Na+), and potassium (K+) and anions like chloride (Cl-), fluoride (F), nitrate (NO3-) and sulphate (SO42-) and heavy metals such as Copper (Cu), Zinc (Zn2+), magnesium (Mg), and Iron (Fe) are all measured using American Public Health Association (APHA)standard methods of analysis. The results were compared with standard values established by agencies such as World Health Organization (WHO), the Bureau of Indian Standards (BIS) and National Drinking Water Quality Standard (NDWQS). The Water Quality Index ranged from 11.66 to 147.11. The results indicate that about 52.9% of the water samples investigated in this study is excellent. Keywords: Drinking water, Chennai city, Physico-chemical parameters, Water quality index (WQI).
Preparation and Bio Pharmaceutical Evaluation of Chrono Pharmaceutical Drug Delivery System of Atenolol
Authors: james Apollo , khanam Jasmina , Palanisamy Mohanraj , Radhakrishnan Arun
Published: May 2022

A time-adjustable pulsatile release system containing atenolol as an active pharmaceutical agent was developed for bedtime dosage administration and release of medicine in the early morning to manage elevated blood pressure. The system contained an immediate release (IR) core, a sustained-release (SR) plug, and a mucoadhesive cup layer and it was designed by the cup and core technique. The immediate-release layer was composed of atenolol, croscarmellose sodium, microcrystalline cellulose (MCC), sorbitol, talc, and magnesium stearate. The SR plug was composed of hydroxyl propyl methylcellulose (HPMC), polyvinyl pyrrolidine (PVP), MCC, Lactose, talc, and magnesium stearate. The mucoadhesive cup contains polycaprolactone and mucoadhesive polymer chitosan. Bilayer tablets were punched by applying different compressive forces. Based on the Release data of the drug from each layer F5 and S5 were selected for the preparation of the bilayer tablet. Cup composition containing 3% of chitosan provided the highest mucoadhesion time up to 10h. Pulsatile delivery of the drug from the formulation was observed at 300 min after the administration of the drug. The constructed pulsatile delivery systems were compared to that of commercially available atenolol IR tablet. The comparison demonstrated that the formulation is suitable for the intended chronopharmaceutical delivery of antihypertensive drugs. Keywords: Chronopharmaceuticals, Pulsatile Drug Delivery, Hypertension, Mucoadhesive Polymer, Atenolol
Studies in the Arts: An Artistic-Scientific Doctorate
Authors: Gartmann Thomas
Published: May 2022

Since 2011, the University of Bern and the Bern Academy of the Arts have been running a joint interdisciplinary artistic-scientific doctoral programme that is unique. This article presents the programme and its contents, but also its challenges, results, and perspectives. An in-depth interview by Angelika Boeck and Peter Tepe with Thomas Gartmann is in preparation.
Rhetorical Move Analysis of Science and Engineering Abstracts Rejected in a Scopus-Indexed Journal
Authors: Syifa Fauzia Qurratu’aini  , Eri Kurniawan  , Arif Husein Lubis
Published: May 2022

The role of an appropriate writing of an abstract becomes significantly important as it acts not only as the representative of the whole content of the paper, but also helps journal reviewers to decide whether the article is deemed worthy to be published. While myriad research on rhetorical move analysis of research article abstracts has been conducted, an inadequate amount of them has probed onto rejected research article abstracts, specifically using a cross-disciplinary lens. This study aims to uncover the rhetorical organization and linguistic features of science and sngineering abstracts by utilizing Hyland’s (2000) rhetorical structure. The method of this research is used as the nature of this research rooted from discourse analysis. A total of eighteen rejected abstracts were retrieved from Indonesian Journal of Science and Technology (IJoST). The findings revealed that all of Hyland’s moves were found in both dataset where the move occurrences were identical to one another. However, significant differences existed in step occurrences, particularly in Step 4 of Move 1, Step 1*, 1, and 2 of Move 3, and Step 1 and 2 of Move 5. Engineering studies considered Introduction, Purpose, and Method as obligatory moves, while science studies viewed Purpose as a conventional move of the three. Pattern-wise, science applied two configurations, while engineering used three. Regarding the linguistic features, present tense and active voice were dominant across the disciplines. Furthemore, it was observed that the conventionality of abstract writing had not been properly performed in the rejected abstracts. This research is hoped to provide an insightful source on rejected research article abstracts to future researchers.
The Principles of Language Politeness in Putri Untuk Pangeran Soap Opera
Authors: Marthin Herci Brand  , I Wayan Budiarta  , I Gusti Ayu Agung Dian Susanthi
Published: May 2022

This study aims to describe (1) the fulfillment and violations of language politeness, (2) the function of language politeness, and (3) the implicature of language politeness. The theory used in this study is the politeness theory proposed by Leech (1983). This type of research is descriptive qualitative. The method used in this research is to use documentation method, observation method and note taking technique. This type of research is descriptive qualitative. The source of data in this study is 32 downloaded episodes of sinetron that were rerun on RCTI’s official account on YouTube. Researchers used documentation methods, observation methods, and note taking techniques to collect the data. The data that has been collected is classified first. Then the data is analyzed based on fufillment and violation, function and implicature of language politeness. Research results are presented using informal methods. The results shows that there were 5 maxims in Sinetron Putri Untuk Pangeran, namely 7 maxims of wisdom, 8 maxims of generosity, 7 maxims of respect and 1 maxim of violation of respect, 1 maxim of humility and 1 maxim of compatibility maxim and 2 violations of compatibility maxim. The politeness functions found consist of 4 declarative functions, 10 interrogative functions, 31 imperative functions, 4 apologizing functions and 4 criticizing functions. The implicatures contained in this sinteron are 1 conventional implicature, 6 unconventional implicatures and 8 assumptions from implicatures.
‘Ayn Al-A‘yān
Authors: Calis Halim
Published: May 2022

Muḥammad ibn Ḥamza Shams al-Dīn al-Fanārī (1350-1431) was one of the prominent early Ottoman scholars. After years of education in Anatolia and Egypt, he served as a mudarris and a judge in the Ottoman lands and was consequently promoted to the post of Shaykh al-Islām, the highest office in the Ottoman religious bureaucracy. ‘Ayn al-a‘yān, Fanārī's partial commentary on the opening chapter of the Qur’an, is an outstanding Tafsīr work, in which Fanārī presents his exegetical theory. In his theory, the Qur’anic text is assessed as having multi-layered meanings, including an esoteric sense, and as being open to endless attempts at interpretation. Fanārī connects the multiple layers of Qur’anic meaning with the hierarchical structure of existence theorised in Akbarī metaphysics. Since the text encodes the secrets of existence at the level of esoteric sense, the task of the commentator involves spiritual experience beyond intellectual inquiry. Therefore, in Fanārī’s commentary, the Qur’anic text functions as an epistemological medium that connects Akbarī ontology to spirituality. The appropriation of Akbarī hermeneutics led Fanārī to question the nature and the authority of Tafsīr and to re-define the Qur’an and exegesis of the Qur’an.
First Vernacular Tafsir in the Caucasus
Authors: Yakubovych Mykhaylo
Published: May 2022

The Azerbaijani language (also referred as Azerbaijani Turkish) is one of the most important languages of Islam in the South Caucasus region. Nowadays spoken by at least 25 million people in the Republic of Azerbaijan, Iran and Georgia, usage of Azerbaijani as a vernacular language has played an important role in the rise of Islamic reformism in the area during the first decade of the 20th century and, almost a century later, in the Islamic revival that has taken place since 1991. At the turn of the 20th century, two vernacular Qur’ān commentaries by Azerbaijani scholars, Kashf al-Ḥaqāʾiq ʿan Nukat al-Ayāt wa’l-Daqāʾīq (1904–1905) by Mīr Muḥammad Karīm al-Bākuwī and al-Bayān fī tafsīr al-Qurʾān (1908) by Muḥammad Mawlā Zādah al-Shakawī, opened new avenues in the debate about the translatability and interpretation of the Qur’ān in non-Arabic discourses, as well as the status of those sources in local Islamic education. This study argues, despite the many dramatic changes brought about by atheist Soviet policies between 1920 and 1991, the impact of these two early 20th century tafsir on modern-day Azerbaijani Islamic education and scholarship has remained substantial, and their influence can be seen in everything from Qur’ānic studies courses in the current curricula of theological colleges to the most recent translations of the Qur’ān in Azerbaijan and beyond.
Inscribing Persian in the Arabic Cosmopolis
Authors: Daneshgar Majid , Rizvi Sajjad
Published: May 2022

Scholarly discourse on the Persianate tends to focus on the influence of Persian in Iran and further east, and often occludes the way in which the Persian language is inflected and present in the Arabic cosmopolis further west. Similarly, the formation of ‘Islamic classics’ and scholarly genres including exegesis tends to ignore the role of Persian works (and texts produced in a Persianate context). Through a case study of Qur’ānic exegesis in Persian and its reception west of Iran, we demonstrate how Persian is inscribed into the Arabic cosmopolis such that the development of post-classical exegesis should place these works alongside the major Arabic classics of al-Ṭabarī, al-Thaʿlabī and al-Basīṭ; in effect, we contend the study of Qur’ānic exegesis cannot ignore the study of Persian exegesis. Through examining rare manuscripts, we show how scholars read, copied and promoted Persian tafsir in Arabophone contexts. Not only does this study follow up on and test some earlier scholarly works dealing with the circulation of Persian translations of the Qur’ān and its commentaries as well as the scholarly impact of the Persians further west, it indicates the contribution of Persian exegesis to a normative understanding of the Islamic exegetical traditions at the heart of the madrasa.