bluuebunny/crossref_metadata_2025 huggingface dataset:
Efecto del veneno de Bothrops diporus sobre la expresión de laminina 5 en biopsias de pie equino
Authors: Teibler Pamela , Aguirre María , Stoyanoff Tania , Núñez Sandra , Maruñak Silvana
Published: June 2018

El objetivo del presente trabajo fue estudiar la expresión de laminina 5 en cortes de biopsias de pie equino precultivados con veneno de serpiente Bothrops diporus por histopatología e inmunohistoquímica contra controles no tratados. Las membranas basales de las láminas de las biopsias, así como las de las arteriolas y venas interlamelares evidenciaron intensa inmunomarcación de laminina 5 (L-5) en los cultivos controles; sin embargo, fue significativamente menor en las biopsias precultivadas con el veneno de B. diporus concomitantemente con la disrupción de la histoarquitectura típica de las laminillas. Estos resultados describen por primera vez la normo-localización de L-5 en biopsias de pie equino y el efecto de las metaloproteinasas, componentes de los venenos de B. diporus, tanto en la integridad lamelar como en los componentes de la vascularización.
Ecología trófica del búho terrestre Athene cunicularia punensis (Strigiformes: Strigidae) en el archipiélago de Jambelí, provincia de El Oro, suroeste de Ecuador
Authors: Orihuela Torres Adrian , Ordóñez-Delgado Leonardo , Brito Jorge , López Fausto , Mazón Marina , Freile Juan F.
Published: June 2018

Estudiamos la dieta del búho terrestre Athene cunicularia punensis en cuatro territorios dentro del archipiélago de Jambelí, provincia de El Oro, suroeste de Ecuador, entre noviembre de 2015 y abril de 2016, mediante la recolección y análisis de 182 egagrópilas. Los artrópodos constituyeron el principal grupo-presa en frecuencia de aparición (86.5%), seguido por los mamíferos (12%) y las aves (1.5%). En cuanto a biomasa consumida, los mamíferos (Mus musculus y Rattus rattus) aportaron 58.5%, los artrópodos 33.2% y las aves 8.2%. No encontramos diferencias significativas de la dieta entre las cuatro parejas estudiadas. En este trabajo se confirmó el rol de Athene cunicularia como un importante depredador de plagas como roedores introducidos y artrópodos potencialmente dañinos.
Two new species in the Drosophila flavopilosa and Drosophila morelia species groups (Diptera: Drosophilidae) in the eastern Andes of Ecuador
Authors: Ramos Guillín Emily , Rafael Violeta
Published: June 2018

One species in the Drosophila flavopilosa species group and another in the Drosophila morelia species group (Diptera: Drosophilidae) are described and illustrated. The larvae of the flies in these groups develop exclusively in flowers and, usually, are rarely collected from rotten plant parts. However, in this case, these new species were not collected from flowers but were captured with fermented banana and yeast. It indicates that this species may be attracted to the odors of yeast fermentation and not only solanaceous flowers. The specimens were collected at 3362 m above sea level. There are four species of the Drosophila flavopilosa species group and one species of the Drosophila morelia species group previously described from Ecuador. The new species are: Drosophila pseudokorefae sp. nov. in the Drosophila flavopilosa species group and Drosophila pseudomorelia sp. nov. in the Drosophila morelia species group.
Characteristics of Children Hospitalized for Psychogenic Nonepileptic Seizures Due to Conversion Disorder Versus Epilepsy
Authors: Luthy Sarah K. , Moss Angela F. , Torok Michelle R. , McLeod Lisa , Wilson Karen M.
Published: June 2018

OBJECTIVES:

Psychogenic nonepileptic seizures (PNES) are a manifestation of conversion disorder among children but can be difficult to distinguish from epilepsy. We sought to identify characteristics that differentiate children with PNES from those with epilepsy.

METHODS:

We conducted a retrospective cohort study of children admitted with epilepsy or PNES to 45 children’s hospitals from 2004 to 2014. Children with PNES (n = 399) versus those with epilepsy (n = 13 241) were compared on demographic and clinical characteristics, testing, treatment, and health care use. Hierarchical multivariable logistic regression was used to identify characteristics associated with PNES diagnosis.

RESULTS:

Children with PNES were more likely to be female (adjusted odds ratio [aOR] 2.3; 95% confidence interval [CI] 1.8–3.0), older (aOR 3.8; 95% CI 2.7–5.3 for 14–16 years old), African American (aOR 2.0; 95% CI 1.5–2.7), and have diagnosis codes for psychiatric disorders (aOR 7.1; 95% CI 5.6–9.1) and pain (aOR 2.6; 95% CI 1.9–3.4). They were also more likely to be admitted in the fall (aOR 2.0; 95% CI 1.4–2.8) or spring (aOR 1.9; 95% CI 1.4–2.6) versus summer. Total adjusted hospitalization costs were greater for children with epilepsy ($4724, 95% CI $4413–$5057 vs $5326, 95% CI $5259–$5393; P = .001); length of stay was similar.

CONCLUSIONS:

Demographic and clinical characteristics differed among children with PNES versus those with epilepsy, including significantly increased odds of psychiatric and pain diagnoses among children with PNES. To better inform treatment and prognostication for children with PNES, research is needed to understand reasons for these differences, seasonal admission patterns, and the relationship between PNES and other psychiatric disorders.
Teamwork on Rounds on an Inpatient Ward Team: An Ethnographic Study
Authors: Falco Carla , Balmer Dorene
Published: June 2018

BACKGROUND AND OBJECTIVES:

Pediatric hospitalists are expected to be adept at effective teamwork; yet, studies in which researchers describe teamwork practices in general pediatric inpatient settings are lacking. Our aim in this study was to examine the roles that general pediatric team members assume in real-life settings and how team members conduct teamwork practices on family-centered rounds.

METHODS:

In the ethnographic tradition, we observed a general pediatric team on a hospitalist service, focusing on family-centered rounds, and conducted in-depth interviews with interns, senior residents, and faculty. We collected data in the form of field notes from observations and transcribed interviews and used constant comparison methods to create codes and generate themes. We used Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS) as an analytic lens and organizing framework.

RESULTS:

Communication occurred in both structured and unstructured ways. Situation monitoring happened during routines, such as running the list, and led to creating a plan of patient care through shared decision-making. Some leadership characteristics were not exclusive to 1 team member. Finally, mutual support occurred through task completion and empowering learners; for example, attending physicians empowered senior residents, who also helped interns.

CONCLUSIONS:

Our findings aligned with some, but not all, teamwork principles from TeamSTEPPS; misalignment may be due to contextual factors, such as the need to provide medical education and the development of grassroots routines (eg, running the list). Context is a key consideration when developing interventions to enhance teamwork on inpatient medical wards.
Psychiatric Diagnoses and Weight Loss Among Adolescents Receiving Sleeve Gastrectomy
Authors: Mackey Eleanor R. , Wang Jichuan , Harrington Chloe , Nadler Evan P.
Published: June 2018

BACKGROUND AND OBJECTIVES:

Severe obesity is associated with higher risk of psychiatric difficulties. Bariatric surgery is the most effective treatment of severe obesity. Few guidelines exist regarding the association of psychiatric diagnoses in adolescents and outcomes after surgery because of the lack of longitudinal research. Our objective is to evaluate the rates of psychiatric diagnoses in adolescents undergoing surgery compared with those not receiving surgery and the association of preoperative psychiatric diagnoses with postsurgical weight loss outcomes.

METHODS:

Adolescents (N = 222) referred for psychological evaluation at one institution for bariatric surgery (2009–2017) completed semistructured clinical interviews to assess the presence and number of psychiatric diagnoses. Comparison analyses were conducted between those who did not end up receiving surgery (N = 53) and those who did (N = 169). Using longitudinal modeling, we assessed the association of preoperative diagnoses with weight loss outcomes between 3 and 12 months after surgery.

RESULTS:

Seventy-one percent of adolescents qualified for a psychiatric disorder. There were no differences in rates of specific disorders or numbers of diagnoses between those receiving surgery and those not receiving surgery. The presence or absence or number of diagnoses before surgery was not associated with weight loss outcomes after surgery.

CONCLUSIONS:

Psychiatric diagnoses are prevalent among adolescents with severe obesity. These diagnoses are not associated with weight loss outcomes. The presurgical psychological evaluation serves as an opportunity to identify adolescents experiencing psychiatric problems and provide them with care but should not necessarily be considered a contraindication to surgery.
Staphylococcus aureus
Authors: Ondusko Devlynne S. , Nolt Dawn
Published: June 2018

Staphylococcus aureus is a bacterium that can cause a variety of illnesses through suppurative or nonsuppurative (toxin-mediated) means. S aureus is a common cause of skin and skin structure infections as well as osteoarticular infections in the pediatric population. S aureus is also identified in cases of septicemia, infective endocarditis, pneumonia, ocular infections, and central nervous system infections. To design appropriate empirical therapy, pediatricians should be knowledgeable about the resistance patterns of S aureus in their communities, including methicillin and clindamycin resistance. This article reviews the microbiology, colonization and transmission, and antibiotic resistance of and clinical diseases caused by S aureus.
Paleocryogenic processes in the Volyn` Upland
Authors: Bonchkovskyi О. S.
Published: June 2018

On the basis of the study of 13 Quaternary loess-soil sections in the Volyn’ Upland, cryogenic horizons of different ranges have been recorded and positioned within the Quaternaty stratigrpahical framework of Ukraine. A short-period cyclicity in development of cryogenic processes has been revealed. Time units of formation of cryostuctures − ‘cryostages’ – have been ranged into four categories in correspondence with landscape-climate conditions of their formation and their relations with the units of paleogeogrpahic framework of Ukraine. The differences in cryostructures and cryodeformations for each category of cryostages are shown. A variety of cryostructures and their sizes became larger from the beginning to the end of the Pleistocene that reflects an increase in the climate harshness. Six cryogenic stages were revealed for Early Pleistocene: mr2, sl, lb1b1-b2, lb2, lb3b1-b2, tl. At these times, small ice wedges, ground wedges, solifluction and different types of postcryogenic textures were formed. The cryogenic processes during the Middle Pleistocene developed more intensely. Six Middle Pleistocene cryostages were established: zv2, zv3b1-b2, or, pt2, pt3b-c, dn. The complex of cryostructures of the majority of these stages include large ice wedges, different types of ground wedges, diverse solifluction forms, and tundra spots-medallions. The largest cryogenic structures and deformations are revealed for the cold time spans during the Late Pleistocene: ice wedges (reach up to 5 m in depth), tundra spots-medallions, sand wedges, solifluction and congelifluction forms, different types of ground wedges and postcryogenic textures. Sixteen Last Pleistocene cryostages are revealed: kd1a-b, kd1b1-b2, kd2, kd3b1-b2, ts, pl1a-b, pl1b1-b2, pl1b-c, pl2, pl3b1-b2, ud, vt1b1-b2, vt2, bg, pc1, pc3. The specific features and sizes of cryostructures and cryodeformation of each cold stage, substage and phase have been used as a base for reconstruction of their geocryological conditions.
Морфологічні різновиди гематиту та їх перерозподіл по продуктах збагачення відсіву дробильно-сортувальних фабрик шахт Криворізького басейну
Authors: Demchenko O. S. , Evtekhov V. D. , Evtekhova A. V.
Published: June 2018

Наведено результати вивчення петрографічного та мінерального складу відсіву дробильно-сортувальних фабрик шахт Криворізького басейну. Головні петрографічні компоненти відсіву – рядові і збагачені гематитові кварцити, багаті гематитові руди; другорядні – малорудні та безрудні кварцити, різного складу сланці, граніти, амфіболіти, жильний кварц. За даними мінералогічних досліджень, відсів має практично бімінеральний (гематит + кварц) склад. Детально досліджено особливості головного рудотвірного мінералу відсіву – гематиту. Виявлено характер перерозподілу його різних морфологічних відмін по різних продуктах рудопідготовки та збагачення. Показано, що емульсійний гематит нерудних прошарків гематитових кварцитів і дисперсний гематит «краскових» руд і малорудних гематитових кварцитів потрапляють, головним чином, до відходів збагачення. Спекулярит і мартит практично повністю потрапляють до концентрату. Наголошується на необхідності врахування одержаних результатів для мінералогічного обґрунтування оптимальної технології повторного збагачення відсіву з метою одержання високоякісного залізорудного концентрату.
Famenian palynostratigraphy of the Volyn–Podillya margin of the East–Europian platform
Authors: Ivanina Antonina V.
Published: June 2018

Famenian carbonate-terrigenous deposits with thickness іn 300-580 m are widely distributed within the Volyn-Podillia margin of the East-European platform. It is the facies-varying complex of rocks, the stratification of which is very difficult because there are no faunal remains in the sediments (with the exception of the lower part). Therefore, during the study of this stratum, the palynological method and the palynostratigraphic division are very important. The main purposes of this study are to identify palynozones, distinguish their generalized description and to create a local scale of the palynological zonation - the vertical succesion of biozones. The material for research consists of more than 450 samples, selected from 31 boreholes. The main method is the facial-palynological analysis, or the method of palynoorictocenosis. This is the first study to perform the standardized description of the biostratigraphic units determined by the palynological data for the Famennian of the Volyn-Podillia margin of the East-European platform. In general, five palynozones are allocated in the Famennian. All palynozones are comprehensively documented thanks to numerous palynological data, characterized by a zonal spore assemblage, in the structure of which there are following categories of taxa: based on the vertical range characteristics - key, characteristic, transit ones; on the content - subdominant, accessory. According to spreading peculiarities of key and characteristic species the following types of bio-units are identified: the Range-Zone (two units) and the Concurent-Range Zone (three ones). General the Famenian deposits of the Volyn-Podillia margin of the East-European platform were palynologically subdivided into lebedianensis–magnificus (the oldest zone), varicornata, cassis–lupinovitchi, versabilis –hamulus, lepidophyta (the youngest unit) miospore zones. Palynozones with a thickness from 17 to 231 m are laterally widespreaded, recorded from a number of boreholes within Volyn-Podillya. They have a set of palynological features that allow easy recognition of deposits. Palynozones detail the sequence bedding, complement the paleontological characteristic and form the local palynological zonal scheme of the Famenian of the Volyn-Podillia margin of the East-European platform.
Доробок професора Володимира Христофоровича Геворк’яна в пізнанні дна акваторії Світового океану (до 85-річчя з дня народження)
Authors: Polovka S. G. , Lavryk O. D. , Dovbysh S. M. , Polovka O. А.
Published: June 2018

Здійснено історичний зріз основних віх життя і висвітлено наукові напрацювання, організаційну і громадську діяльність відомого в Україні та за її межами морського геолога, доктора геолого-мінералогічних наук, професора Володимира Христофоровича Геворк’яна. Персоналізація геології океанів і морів в Україні дає можливість визначити етапи подальшого розвитку її наукових напрямів й надає історії української науки та освіти портретної конкретики. Вказані аспекти визначають актуальність дослідження. Тому за мету статті обрано висвітлення історичних віх життєвого шляху і наукової, дослідницької і педагогічної та громадської діяльності професора В. Х. Геворк’яна. Показано коло його наукових інтересів та акцентовано увагу на започаткованих науковцем трьох нових наукових напрямах у галузі геології океанів і морів в Україні. Значна частина статті присвячена розкриттю новітніх теоретичних напрацювань В. Х. Геворк’яна: висунення та обґрунтування нової концепції – аседиментаційної трансформації і мобілізації осадових порід та відкладів через вплив на них глибинних флюїдів; ролі органічної речовини в процесах аутигенного мінералоутворення, її значенню для формування горючих корисних копалин і для з’ясування більш загальних питань колообігу вуглецю у біосфері Землі; однієї з моделей відродження науково-дослідного флоту в Україні.
ONLİNE ALIŞVERİŞ SİTESİ KULLANICI ALGILARININ MÜŞTERİ GÜVEN VE SADAKATİNE ETKİLERİNİN İNCELENMESİ
Authors: ATEŞ Vildan
Published: June 2018

Bu
çalışmanın amacı, Türkiye’deki online alışveriş sitesi kullanıcı algılarının
müşteri güven ve sadakati üzerine etkilerinin belirlenmesidir. Literatür
kapsamlı bir şekilde incelenerek müşteri güven ve sadakatini etkileyen müşteri
algıları belirlenmiş ve bir kuramsal model önerilmiştir. Çalışma grubu
Ankara’daki bir devlet üniversitesinin eğitim fakültesinde 2015-2016 öğretim
yılı bahar döneminde öğrenim gören 553 öğrenciden oluşmaktadır. Veriler 32
maddeden oluşan ölçek ile toplanmıştır. Açımlayıcı faktör analizi (AFA) ve doğrulayıcı faktör analizi (DFA)
teknikleri kullanılarak modelin uygunluğu test edilmiştir. Analiz sonucunda online müşteri
algılarından kontrol, değer, fayda ve risk algılarının online müşteri güveni
üzerinde istatistiksel olarak anlamlı etkileri olduğu görülürken online
alışveriş öz-yeterlilik ve kişiselleştirme algılarının müşteri güveni üzerinde
istatistiksel olarak anlamlı bir etkisinin bulunmadığı görülmüştür. Online müşteri güveni müşteri sadakati
üzerinde istatistiksel olarak anlamlı ve pozitif etkiye sahip olup müşteri
algıları ile müşteri sadakati arasında aracı bir rol üstlendiği tespit
edilmiştir. Kuramsal modelle bulgular ilgili literatür ile karşılaştırılarak araştırmacılar ile online
alışveriş sitelerine yönelik öneriler sunulmuştur.
LN34 pan-lyssavirus real-time RT-PCR for post-mortem diagnosis of rabies in animals v1
Authors: M. Gigante Crystal , Wilkins Kimberly , Edgar Condori Condori Rene , Li Yu
Published: June 2018

Purpose To describe the LN34 real-time RT-PCR assay procedure used for the qualitative detection of lyssavirus RNA in whole RNA extracted from brain tissue samples. The assay detects RNA from diverse lyssaviruses at varying concentrations [1].
Predicting the progression of ophthalmic disease based on slit-lamp images using a deep temporal sequence network v1
Authors: Jiang Jiewei , Liu Xiyang , Liu Lin , Wang Shuai , Long Erping , Yang Haoqing , Yuan Fuqiang , Yu Deying , Zhang Kai , Wang Liming , Liu Zhenzhen , Wang Dongni , Xi ChangZun , Lin Zhuoling , Wu Xiaohang , Cui Jiangtao , Zhu Mingmin , Lin Haotian
Published: June 2018

Ocular images play an essential role in ophthalmology. Current research mainly focus on computer-aided diagnosis using slit-lamp images, however few studies have been done to predict the progression of ophthalmic disease. Therefore by exploring an effective approach of prediction can help to plan treatment strategies and to provide early warning for the patients. In this study, we present an end-to-endtemporal sequence network (TempSeq-Net) to automatically predict the progression of ophthalmic diseases based on consecutive slit-lamp images. First, we comprehensively compare six potential combinations of three convolutional neural networks and long short term memory (or recurrent neural network) in terms of effectiveness and efficiency, to obtain the optimal TempSeq-Net model. Second, we analyze the impacts of sequence lengths on model’s performance which help to evaluate their stability and validity and to determine the appropriate range of sequence lengths.
Introduction to molecular phylogenetic reconstruction with the ETE3 Toolkit v1
Authors: O Aylward Frank
Published: June 2018

This is a short tutorial on how to get started analyzing FASTA files via the command line. Code is intended for use on an Ubuntu 16.04 LTS OS, but it may work on other Unix or Unix-like systems. Here we will use the ETE3 toolkit, which is a very nice tool for phylogenetic reconstruction. The main website is here:http://etetoolkit.org/ We will also look at the EggNOG database, which is a very useful database of protein families:http://eggnogdb.embl.de/#/app/home
invertedClampFISH ligation v1
Authors: Emert Benjamin
Published: June 2018

Protocol formaking invertedClampFISH probes.
Assessment of indications of caesarean section among high risk women by Robson criteria: a prospective study
Authors: Patel Kaveri Shaw , Nag Roma S.
Published: June 2018

Background: Caesarean section (CS) is a surgical intervention for safe delivery other than natural vaginal route. World Health Organization (WHO) has recommended ten group classification systems of Robson criteria which we have used to analyse CS at our center. The objective of the study to analyse the lower section caesarian section (LSCS) data under Robson criteria for implementation in regular practice in tertiary care center and to understand the need of it for future practice.Methods: A prospective analysis done for deliveries in Obstetric Department of Shalby Multispecialty Hospital of central India by Robson ten group classification criteria. The study was carried out for the period of two year from April 2016 to April 2018 including antenatal women attending labour room with high risks or referred cases from other centers.Results: The study reflected overall 196 live birth of high risk cases which were having other co morbidities like pre-eclampsia, eclampsia, hypothyroidism, diabetes, acute viral hepatitis. The data compared with Robsons guidelines and reflected that the centre is dealing with high risk primigravida (47.51%, 35-42% Robson criteria) cases with high CS rate (16.8%, group 5). There was multiple pregnancy, group 8, (2.32 %, >1.5-2% Robson Criteria) and preterm births as in group 10, 18.02 % (5% in Robson Criteria), exclusively high.Conclusions: The Robson criteria help to classify the population handled by the canter to develop the strategies for betterment of services. It has limitation in view of qualitative assessment of the data for comorbidities and severity of the disease.
Demographic and clinic-angiographic profile of coronary artery disease in young adults: a retrospective observational study
Authors: Swain Lalatendu , Routray Prabhat Nalini
Published: June 2018

Background: Cardiovascular diseases (CVD) and its complications are on an increased trend in the younger age group. In this study we aimed to identify the different risk factor profile and coronary angiographic characteristics of young adults presenting with coronary artery disease.Methods: We conducted this retrospective observational study at SCB MC and H and Ashwini Hospital, Cuttack, Odisha, India over a period of one year from June 2016 to June 2017 on 170 patients who undergone coronary angiogram. Inclusion criteria being patients admitted for STEMI, NSTEMI, or UA, age <40 years and those who underwent coronary angiography. All patients who underwent coronary angiography for surgical fitness e.g., patients of rheumatic heart disease and congenital heart disease were excluded from the study.Results: Among the 150 cases included in the study, 85.3%were males and 14.7% were females. Maximum number of cases i.e. 71.3% were in the age group 36-40 yr, while 23.3% were between 31-35 and 5.4% were between 25-30 age group. Among 150 cases with critical CAD, SVD was most prevalent seen in 68.7% cases, followed by DVD in 22.6% and TVD in 8.7% cases.Conclusions: Incidence of critical CAD in young adults is quite high. Young patients with CAD are mainly males, and SVD is more common. Comparative analysis of young patients with STEMI and NTEMI/ UA revealed that SVD was predominantly involved in STEMI group, whereas TVD was predominant in NSTEMI/UA group.
Clinical profile of premenopausal female patients with coronary artery disease
Authors: T. D. Unnikrishnan Kartha , N. R. Ambili , Mathew Donna , B. Renymol
Published: June 2018

Background: Coronary artery disease is becoming the leading cause of death in the world. The incidence of CAD in females has increased rapidly in the past decades. This study aimed to analyze the clinical profile of premenopausal women with CAD and elucidate on the possible risk factors.Methods: Premenopausal female patients admitted with an acute coronary syndrome as diagnosed by history, ECG and laboratory tests were recruited. Clinical and biochemical parameters were recorded.Results: Mean age of study participants was 41.6±8.18 yrs. Unstable angina (60%) was the most common clinical presentation. Proportion of women with various risk factors of CAD in our study population were as follows dyslipidemia (65%), family history of premature CAD (57.5%), hypertension (55%), diabetes mellitus (42.5%), hypothyroidism (40%), PAD (37.5%), CKD (35%) and SLE (20%). Most (95%) of the study population had high LDL-c. Three fourth (77.5%) of the study population had low HDL Approximately half of the study population had fatty liver on ultrasonography. Triglyceridemia was found in 72.5% of the study population.Conclusions: Premature CAD is increasingly evident in young premenopausal women in India. Premenopausal CAD in India is of multi factorial causation and dyslipidemia, hypertension, diabetes mellitus, central obesity and family history of premature CAD play a crucial role in its development.
Laparoscopic ventral hernia mesh repair without the use of transfascial sutures: our experience
Authors: D. Wasim M. , Muddebihal Uday , Rao U. V. , J. Praveen
Published: June 2018

Background: Repair of the abdominal wall defects can be quite challenging even for most experienced surgeon under best of conditions. In the laparoscopic method there have been many modifications with regard to the type of mesh and methods of fixation. The aim of this study was to identify immediate post-operative pain and the long-term outcomes of laparoscopic ventral hernia mesh repair without the use of transfascial sutures to fix the mesh.Methods: A total of hundred (n=100) patients underwent Laparoscopic Ventral Hernia Mesh Repair by our surgical unit between January 2011 and December 2015. All patients underwent standardized Laparoscopic mesh repair with light weight composite meshes and without the use of transfascial sutures. Only absorbable tackers were used to anchor the mesh. Analgesics stopped after 24 hours or given only on demand. Mesh fixation time, post-operative pain score (visual analogue score), and follow up for pain and recurrence (at 6 months, 12 months and 24 months) were recorded and analyzed.Results: Out of 100 patients (42 men and 58 women), the mean age was 48 years and BMI of the patients was 20-35. Types of hernias operated were 63 para umbilical hernias, 32 incisional and 5 recurrent hernias. The median defect size was 5 cm (Range 3-8 cm) and the mesh sizes used were15 x 15 cm circular (87) and 15 x 20 rectangular (13). The median mesh fixation time with only absorbable tackers was 15 mins (range 15-20 mins). Visual analog scale for pain (VAS) was of median 1 (Range 0-2) at 24 hours. Five patients required analgesics for 48 hours. No patients complained of pain at follow ups (1 month, 6 months, 12 months and 24 months). Mean hospital stay post operatively was 2-3 days. Only one patient had recurrence of hernia within 6 monthsConclusions: Laparoscopic Ventral Hernia Mesh Repair without the use of transfascial sutures is an easy and feasible approach. The use of only absorbable tacks to fix the mesh is time saving and gives less post-operative pain. However, randomized controlled trials are required to compare transfascial sutures with absorbable tacks for fixing the mesh in separate cases to reach a standardized method.
Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation
Authors: Satoh Takashi , Igarashi Ayaka , Tanno Misaki , Yamada Koki , Takahashi-Suzuki Natsuko , Watanabe Kazuhiro
Published: June 2018

Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs). The aim of the present study was to evaluate the inhibitory effects of two b-glucuronidase-treated Japanese traditional herbal medicines (kampo), Hange-Shashin-To (TJ-14) and Sairei-To (TJ-114) on SN-38 glucuronidation, and the deglycosylation of baicalin (BG) and glycyrrhizic acid (GL) derived from TJ-14 and TJ-114 to form their respective aglycones, baicalein (BA) and glycyrrhetinic acid (GA). Methods: The inhibitory effects of b-glucuronidase-treated TJ-14 and TJ-114 on SN-38 glucuronidation by human liver microsomes were examined. BA and GA, which were enzymatically converted from BG and GL present in TJ-14 and TJ-114, were examined in the same manner. Furthermore, the enzymatic activities were measured by using recombinant UGT1A1 and UGT1A9 isoforms instead of human liver microsomes. BA, GA, SN-38, and their glycosides/glucuronides were analyzed with an LC-MS system. Results: As regards the linear initial reaction rate, SN-38 glucuronidation by human liver microsomes was significantly inhibited by the addition of b-glucuronidase-untreated TJ-14 and TJ-114, but was more strongly inhibited by the addition of b-glucuronidase-treated TJ-14 and TJ-114. The results of LC-MS analysis and pharmacokinetic studies suggested that BA is the main inhibitor of SN-38 glucuronidation. In the Dixon plot, BA showed competitive inhibition of SN-38 glucuronidation, and the inhibition constant was 8.70 ± 3.24 mM. Previous reports, studies of recombinant UGT isoforms indicated that SN-38 glucuronidation was mainly catalyzed by UGT1A1. Conclusions: These findings strongly suggested that SN-38 glucuronidation is inhibited by BA. BA could act as a pharmacokinetic regulating factor associated with SN-38 glucuronidation. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Calculating for managing: The emergence of the idea of risk management
Authors: Morales Henao Alejandro
Published: June 2018

Este texto argumenta que el surgimiento de la idea del manejo del riesgo puede rastrearse en el uso de las derivadas en el sector financiero a principios de los años 70. A través de una discusión crítica con la propuesta de Michael Power sobre la consolidación del manejo del riesgo como una práctica organizacional común en los años 90, el artículo afirma que el riesgo como asunto administrable se remonta al uso del modelo Black-Scholes-Merton para fijar los precios de las opciones en el Chicago Board Options Exchange (CBOE) desde 1973. La idea de cálculo, medición y manejo del riesgo se pueden situar hasta ese momento. Este es un ejercicio de teorización que busca identificar el papel de las ideas en las prácticas económicas, de tal manera que se permita una historización del conocimiento técnico.
Nursing professionals' attitudes toward biostatistics: an international web-based survey
Authors: Ocakoğlu Gökhan , Kaya Mehmet Onur , Can Fatma Ezgi , Atış Sema , Macunluoğlu Aslı Ceren
Published: June 2018

Objective: The present
study, an international web-based survey, was focused on four aims: to obtain
nursing professional’s self-reported statistical knowledge levels and how this knowledge varies by
research area, to investigate and specify when biostatistics courses should
be taught in nursing education and to identify the key statistical methods
relevant to nursing education. Methods: A total of 448 nursing
professionals from five continents and 52 countries participated in our study.
For the data comparison, the Kruskal-Wallis test, the Mann-Whitney U test, the
Pearson Chi Square and Fisher-Freeman-Halton tests were applied. Results: The results indicate that while nursing professionals place an emphasis on
biostatistics education, the majority state that biostatistics education should
be taken both at the undergraduate and postgraduate level and the participants
also believe that taking a biostatistics course is useful for their occupation.
A biostatistics education should also emphasize the necessity of consulting to
a biostatistician when planning a study. Conclusion: Our study provides
information regarding self-reported levels of biostatistical knowledge of
nursing professionals by research area and academic position, and provides
guidance regarding the ideal semester for administering a biostatistics course.
Voces levantadas que transformaron el vivir rural de Oxchuc, Chiapas: 1936-1986
Authors: Sántiz Gómez Abraham
Published: June 2018

Este estudio tiene como propósito el mostrar cómo los oxchuquenses desarrollaron acciones colectivas que posicionaron a Oxchuc en los escenarios local, regional y nacional. El diario de campo facilitó recuperar categorías tseltales -como la syantesel jkuxlejaltik- que le dan sentido a la acción colectiva para la construcción del vivir tseltal. La historia oral permitió un análisis de los cambios ocurridos de 1936 a 1986: relaciones sociales con la naturaleza, tensiones entre ancianos y jóvenes, cambios generados por el presbiterianismo, profesores en la lucha de poder por el gobierno municipal, disputas por la tierra y movilidad por el crecimiento poblacional, e interacciones con el mercado desde que inició el cultivo del café. Los resultados muestran a un pueblo tseltal con una cultura dinámica que se liberó de las normas coloniales, aprovechó las oportunidades de cambio sociocultural y construyó relaciones de poder en un mundo globalizado.
Os Supratalare
Authors: Henriques Moisés
Published: June 2018

N/A.
Evaluation of Stiffness and Parametric Modelling of XY Flexure Mechanism for Precision Applications
Authors: Sollpaur Shrishail B , Patil Maharudra S , Deshmukh Suhas P
Published: June 2018

In miniaturized scale electro-mechanical framework (MEMS) flexural instruments are generally utilized in light of their preferences, frictionless and wear less movement and high accuracy. Flexures rely upon material versatility for their usefulness. In flexure component, movement is created because of flexibility of the shaft from which it is made. One of the run of the mill favorable circumstances of flexural system is to increase exact twisting and adaptability to acquire movement wanted way. This paper manages outline, examination and displaying of XY flexure instrument which depends on twofold parallelogram flexure (DFM). The XY system exhibited has solid structure and it depends on twofold parallelogram flexure. Limited component model and investigation is completed in ANSYS 15. Static examination is done to discover constrain avoidance attributes of instrument. Parametric examination is utilized to improve outline parameters of flexure shaft. Limited component examination (FEA) result approves investigative outcomes of component.
Preparation and application of modified zeolites as adsorbents in wastewater treatment
Authors: Shi Jiahui , Yang Zixuan , Dai Hongliang , Lu Xiwu , Peng Lihong , Tan Xiangyi , Shi Lijun , Fahim Raana
Published: June 2018

Natural zeolite has been recognized as a useful adsorbent for wastewater treatment for removing cations. Natural zeolite is a kind of porous material with large specific surface area but limited adsorption capacity. In recent years, emphasis has been given to prepare the surface modified zeolite using various procedures to enhance the potential of zeolite for pollutants. Modification treatment for zeolite can greatly change surface chemistry and pore structure. The article describes various modification methods of zeolite, and introduces the removal mechanisms of common pollutants such as ammonium, phosphorus and heavy metals. In addition, this review paper intends to present feasibility of applying modified zeolite to constructed wetlands which will be beneficial to achieve higher removal effect.
Synthesis of N-substituted Five and Six-membered Iminocyclitols-bearing Sugar Moiety: Strategy Toward the Synthesis of Pseudodisaccharide
Authors: Al Bujuq Nader , Angulo Manuel
Published: June 2018

Aim and Objective: The efficient synthesis of disaccharide containing iminosugar moiety has a considerable
interest in the field of glycoscience. In the present work, we describe a novel and applicable method
for synthesis of five and six-membered N-substituted iminosugars attached with sugar moiety (pseudodisaccharides).

Materials and Methods: The method of the glycosylation was based on the coupling of iminosugar thioglycoside
(glycosyl donors) with partially protected sugars (glycosyl acceptors) in the presence of DMTST as a
promoter. 2D COSY, HMQC, HMBC experiments were carried out to assist in NMR signal assignments. The
pseudoanomeric configuration was established through NOE experiments and molecular modeling calculations.

Results: Two classes of pseudodisaccharides were successfully obtained, five and six-membered N-substituted
iminosugars glycosides. The six-membered pseudodisaccharides compounds were produced selectively with
only β anomer. The corresponding five-membered pseudodisaccharides were achieved with moderate stereoselectivity.
The yields obtained were good. These derivatives of iminocyclitols are thought to be precedents to
develop various pseudodisaccharides, novel biologically active compounds, and new functional molecules.

Conclusion: According to the results, utilizing iminosugar thioglycosides (1 and 2) as a glycosyl donor in glycosylation
reactions is an efficient and highly stereoselective method to prepare (five- and six-membered) iminocyclitols
(iminosugars) that bear a sugar moiety. The results will add to the synthesis of the iminosugars derivatives
and contribute to make our approach among the few methods able to synthesize iminosugar glycosides.
A Review of 2,3-Benzodiazepine-related Compounds: Diazepines and 1,2,5- Triazepines Fused with Five-membered Nitrogen Heterocycles
Authors: Foldesi Tamas , Volk Balazs , Milen Matyas
Published: June 2018

Background: 2,3-Benzodiazepines represent an important class of biologically active compounds,
some members of this family have reached the human clinical stage. With formal bioisosteric replacement of
the benzene ring to five-membered nitrogen heterocycles, several new diazepine and 1,2,5-triazepine
derivatives have been synthesized in the past 30 years.

Objective: Investigations in the field of heterocyclic chemistry is very important, because there could be
several new medicines among the newly synthesized heterocyclic ring systems, which could be used against
several diseases which have no remedy yet, for example some types of cancer. The research on antibacterial
compounds is also an important field because of spreading of multiresistant pathogens. This review aims to
summarize the literature of certain 2,3-benzodiazepine analogues.

Conclusion: After a brief historical introduction, various ring systems containing a 2,3-diazepine or a 1,2,5-
triazepine ring condensed with five-membered nitrogen heterocycles are disclosed. First, pyrrole-fused
compounds are introduced, followed by indole and carbazole derivatives. After that, diverse ring systems
containing an imidazole ring are presented. The review is closed with the chemistry of some interesting
triazole and tetrazole derivatives. Many of these compounds bear significant biological efficacy.
Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde
Authors: Khan Momin , Ali Umar , Ur Rahman Anis , Ibrahim Muhammad , Hameed Abdul , Asif Muhammad , Hussain Zahid , Kanwal  , Khan Khalid Mohammed , Perveen Shahnaz , Rehman Munir ur
Published: June 2018

Background: The role of small molecules as antioxidants to prevent the oxidation of
other molecules and inhibit them from radical formation is the area of much interest to cure disease
especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation
of fuels and lubricants.

Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized
and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring
of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted
aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for
2-10 min.

Results: Our present study showed that all compounds are better ferrous ion-chelating agents except
compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 =
329.26 ± 4.75 µM) which has slightly low activity than the standard EDTA (IC50 = 318.40 ± 5.53
μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity
than the standard. However, remaining four compounds showed comparable radical scavenging
activity to the standard DPPH (IC50 = 257.77 ± 4.60 µM).

Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants.
From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential
to serve as leads for the development of antioxidant agents for future research.
Target Cells for HIV-1/SIV Infection in Mucosal Tissue
Authors: Smith Phillip D. , Shen Ruizhong
Published: June 2018

The mucosal surfaces of the genital and gastrointestinal tracts are the routes by which HIV-1 is acquired, excluding persons infected parenterally. Identification of the mucosal target cells and the receptors by which HIV-1 enters these cells is fundamental to elucidating the biology of HIV-1 transmission. The mucosal target cells include epithelial cells, dendritic cells, Langerhans cells, CD4+ T-cells, macrophages and even mast cells, but the contribution of each cell type is highly dependent on the mucosal surface - genital versus gastrointestinal. Importantly, mucosal target cells may also play key roles in the immunobiology and latency of HIV-1 infection. Given the pivotal role of mucosal cells in HIV-1 transmission and pathogenesis, an effective vaccine to bring the HIV-1 pandemic under control must be effective at the level of the key target cells in both the genital and gastrointestinal mucosae.
Comparison of Maximum Power Point Tracking (MPPT) Algorithms to Control DC-DC Converters in Photovoltaic Systems
Authors: Shadlu Milad Samady
Published: June 2018

Background:

Using the solar energy by photovoltaic arrays is constantly increasing and has
been considered as one of the cleanest sources of energy in recent years. One of the ways to reduce the
cost of photovoltaic systems is to maximize the power delivered to the load. On the other hand,
changing the load leads to change the operating point of the solar conversion system and causes
deviation from the maximum power point (MPP).

Methods:

For this reason, in various research studies, attention has been paid to MPPT methods
applicable in photovoltaic systems. In this paper, a comparison is performed between conventional
MPPT methods including Perturb and Observe (P&O), Incremental Conductance (INC), Fractional
Open Circuit Voltage (FOCV), Ripple Correlation Control (RCC) and Extremum Seeking Control
(ESC). Only current and voltage parameters of the PV panel are measured instantly and used to generate
control signals. However, the output voltage of the PV cells is relatively low without using the DC-DC
converters.

Results:

Therefore, high-performance DC-DC converters need to convert the low voltage PV arrays into
high DC voltages to handle the 220 VAC systems.

Conclusion:

Accordingly, in this study, conventional DC-DC converters including Boost, Buck and
Buck-Boost converters are investigated, and each of them is simulated using different MPPT controllers
and the results are compared together. It is worth noting that all of the simulations are carried out using
MATLAB/Simulink.
Conhecer contextos, conhecer profissionais: Contributo para explorar o desenvolvimento de competências interculturais em contextos educativos
Authors: Santos Silva Daniela Filipa , Marques da Silva Sofia
Published: June 2018

O aumento de mobilidades e de movimentos migratórios na sociedade contemporânea europeia tem reflexo nos mais diversos contextos sociais, trazendo desafios particulares ao campo educativo. Neste alinhamento, as questões da diversidade cultural tornam-se audíveis não apenas pela emergência de situações mediatizadas, mas também porque nos relembram “velhas” diversidades, por vezes esquecidas. Este artigo procura contribuir para uma discussão em torno de preocupações que, sendo também de natureza global, se estendem a contextos educativos locais, onde diversidades culturais se vivem e produzem envolvendo diferentes figuras. O contributo decorre de um estudo qualitativo que procurou dar conta de competências valorizadas, apropriadas e mobilizadas por profissionais em contextos educativos formais, não formais e informais, no trabalho com diversidades étnicas, especificamente com jovens descendentes de imigrantes e de minorias étnicas. As entrevistas semiestruturadas e grupos de discussão focalizada possibilitaram conhecer um conjunto de competências profissionais que se organizaram em três dimensões: uma dimensão relacional, uma dimensão prática e uma dimensão de integração cultural e social.Palavras-chave:Educação inter/multicultural; Competências profissionais; Diversidade cultural; ABSTRACTThe increasing mobility and migration movements in the European contemporary society have impacted multiple social contexts, bringing particular challenges to the education field. In this line, cultural diversity issues become heard, not only due to the emergence of mediatic situations, but also because they remind us of “old” diversities, sometimes forgotten. This article aims to contribute to a discussion which combines global concerns and influences local education contexts. This contribution comes from a qualitative study that aimed to account for competences that were valued, appropriated and used by professionals in formal, non-formal and informal education contexts, while working with ethnic diversities, namely with young people with a migrant background and from ethnic minorities. The semi structured interviews and the focus group discussions allowed us to know a set of professional competences which are organized into three dimensions: relational, practical and cultural and social integration.Keywords: Inter/multicultural education; Professional competences; Cultural diversity