bluuebunny/crossref_metadata_2025 huggingface dataset:
Overview of hybrid filters for protection against conductive interference
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kosteletskii V. P.
Published: December 2022

Conductive interference can penetrate to electronic components of radio-electronic equipment (REE) through the conductors of signal and power circuits. To protect against conductive interference electrical filters are used. The main disadvantage of such a solution is that the electrical filter is a device designed for specific purposes and is often not suitable for related tasks. To ensure electromagnetic compatibility the joint use of electrical filters of different purposes is practiced, such a protection device is called a hybrid. The specific property of a hybrid is that the characteristics of the electrical filters used in its composition compensate for the disadvantages of each other. In this article a review and comparative analysis of hybrid interference filters is made, this review can be used in the design of REE and organization of effective protection from conducted interference.
Development of an algorithm for solving the inverse problem of profit formation with an integer constraint
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Gribanova E. B. , Mustakimov R. R. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

The article presents an algorithm for solving the inverse problem of profit formation, which differs from the existing ones by taking into account the integer characteristics. Based on this algorithm, a web application is implemented to support decision-making to achieve the organization's targets.
Scaling of the disorder operator at deconfined quantum criticality
Authors: Wang Yan-Cheng , Ma Nvsen , Cheng Meng , Meng Zi Yang
Published: December 2022

We study scaling behavior of the disorder parameter, defined as the
expectation value of a symmetry transformation applied to a finite
region, at the deconfined quantum critical point in (2+1)d in the
J-Q_3J−Q3
model via large-scale quantum Monte Carlo simulations. We show that the
disorder parameter for U(1) spin rotation symmetry exhibits perimeter
scaling with a logarithmic correction associated with sharp corners of
the region, as generally expected for a conformally-invariant critical
point. However, for large rotation angle the universal coefficient of
the logarithmic corner correction becomes negative, which is not allowed
in any unitary conformal field theory. We also extract the current
central charge from the small rotation angle scaling, whose value is
much smaller than that of the free theory.
A CASE SERIES ON MANAGEMENT OF SPONTANEOUS CEREBROSPINAL FLUID RHINORRHEA
Authors: Radhakrishnan K.R. , Ranjit Kumar D. , Nagaraja Gurumoorthy M.
Published: December 2022

Introduction: Cerebrospinal fluid (CSF) rhinorrhea is defined as leakage of cerebrospinal fluid that occurs from a direct communication between the CSF-containing subarachnoid space and the paranasal sinuses. Non traumatic or spontaneous CSF rhinorrhea is very rare and reported to have occurred in only 4% of the CSF leak cases. Materials and Methods: A retrospective hospital-based study was conducted in a tertiary care centre on seven cases of spontaneous CSF Rhinorrhea. Observation and Results: Among seven cases, five patients were of age less than 45 years and two patients were more than 45 years old. All subjects were females and were diagnosed with spontaneous CSF rhinorrhea. CT paranasal sinuses and CT Cisternogram were the most common imaging modalities used for diagnosis in all patients. All patients underwent Transnasal endoscopic repair of CSF rhinorrhea. Conclusion: Transnasal endoscopic repair of the defect gives a successful outcome following failure of the conservative management in spontaneous CSF rhinorrhea.
INTEGRATION OF HEALTH WITH INDIAN TRADITIONAL SCIENCE
Authors:   Ph.D. Scholar, Department of Kriya Sharir, Faculty of Ayurveda, IMS, BHU,Varanasi, (221005)., Verma Priyanka , Sharma Rashi ,   Associate Professor, Department of Kriya Sharir, Faculty of Ayurveda, IMS, BHU, Varanasi (221005).
Published: December 2022

For centuries, Yoga and Ayurveda have been contributing an important role in health preservation. The great objective of Ayurveda is to maintain the health of a healthy persons. and to cure the diseases of sick people. in the same way Maharshi Patanjali has been said in Patanjaliyoga Sutra (1:2) Yogasyachittavrittinirodhait means that yoga is the removing of the fluctuation of the mind and experience oneness and union with real Devine. Both Yoga and Ayurveda does not promoteonly physical health, but also emphasize on holistic health. Health is not only a state of physical fitness but also physical, mental, social, spiritualwellbeing. Maharshi Shushruta has also said in the definition of health in Shushrut Samhita (15:38). Samadosha, samagnischa,samadhatumalakriyaha,PrasannaatmenindriyamanhSwasthyaityabhidheeyate.. Acharya Shushrutahasbeen defines health is an equilibrium stage of TriDosha(vata,pitta,kapha),Agni (Jathragni,Bhutagni,Dhatvagni).SaptaDhatu(Ras,Rakta,Mansa,Meda,Asthi,mjja,shukra)andregular excretion of mal (waste product i.e. Mutra, Purish, Sweda) and blissful state of senses, mind and soul, that person is completely healthy. Andalso, World Health Organization defines health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. And in the modern era, everyone is becoming aware of and following the principles of Yoga and Ayurveda to achieve the most optimal state of health and maintain holistic health. Only using Traditional Indian medical practices is it possible to achieve total wellness.
ONE STEP SOLUTION FOR MULTIPLE MARGINAL TISSUE RECESSION IN THIN GINGIVAL BIOTYPE
Authors:   Reader, Department of Periodontology,Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India., Rahman Siddiqui Zeba , Gupta Sanjay ,   Professor and Head, Department of Periodontology, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India., Rahman Sidra ,   Post graduate student, Department of Periodontology, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India.
Published: December 2022

Gingival recession is a common concern due to esthetic and root sensitivity especially in mandibular anterior teeth. Various treatment modalities and mucogingival techniques have been carried out for the treatment of recession. The presence of shallow vestibule, inadequate width of attached gingiva may pose a challenge for which several surgical solutions are reported in the literature. Bridge flap technique is one such technique that can be used as a single surgical entity for covering multiple gingival recession, along with increasing vestibular depth without a second surgical site. The treated cases showed adequate root coverage & increase in width of attached gingiva 12 months post operatively.
IMPACT OF COVID ON DURATION TIME OF TREATMENT IN CERVICAL CANCER
Authors:   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Smiti S. , Majjaoui S.EL ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Allam O.EL ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Taouchikht M. ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Fares H. ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Laraichi R. ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Kacemi H.EL ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Kebdani T. ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco., Hassouni K. ,   Department of Radiation Oncology, National Institute Of Oncology, Mohammed V University, Rabat, Morocco.
Published: December 2022

Duration Time of treatment (DTT) in cervical cancer is an essential prognostic factor. Longer treatment duration n is the most unfavorable prognostic factor for local control. [1]The main objective of this study is to investigate the impact of the pandemic on (DTT) in cervical cancer.Through a unicentric retrospective study carried out at the Radiotherapy department of the National Institute of Oncology, for 2 years, before and during the pandemic. Results: The number of patients followed before the pandemic was 138 and 157 during the pandemic. The average age before the pandemic was 54 and 53 during the pandemic. Squamous cell carcinoma accounted for 91% versus 9% adenocarcinoma. The average spread was 53 days before the pandemic, and 51 days during the pandemic. To facilitate patient care, a guesthouse has been made available to them. Moreover, a new system for programming and organizing brachytherapy was launched in July 2019, to control sprawl in these patients, and avoid its extension. Conclusion: Our study has made it possible to assess the impact of the pandemic on sprawling in our patients and the means to overcome the constraints of travel and organization for treatment within the optimal timeframe, in order to ensure a better local control.
LINTERET DU DECUBITUS VENTRAL EN MILIEU DE REANIMATION : ETUDE PROSPECTIVE AU SERVICE DE REANIMATION CHIRURGICALE DE RABAT
Authors:   Service De Reanimation Urgence Chirurgicale, Centre Hospitalier Universitaire De Rabat, Universite Mohamed V, Rabat, Maroc., Smiti S. , Smiti Y. ,   Service De Reanimation Urgence Chirurgicale, Centre Hospitalier Universitaire De Rabat, Universite Mohamed V, Rabat, Maroc., Bentalha A. ,   Service De Reanimation Urgence Chirurgicale, Centre Hospitalier Universitaire De Rabat, Universite Mohamed V, Rabat, Maroc., Ali Ech Cherif El. Ketani M. ,   Service De Reanimation Urgence Chirurgicale, Centre Hospitalier Universitaire De Rabat, Universite Mohamed V, Rabat, Maroc., Balkhi H. ,   Service De Reanimation Urgence Chirurgicale, Centre Hospitalier Universitaire De Rabat, Universite Mohamed V, Rabat, Maroc., Faroudi M. ,   Service De Reanimation Urgence Chirurgicale, Centre Hospitalier Universitaire De Rabat, Universite Mohamed V, Rabat, Maroc.
Published: December 2022

Le Decubitus ventral est une manÅ“uvre reconnue depuis plus de 30 ans, mais dont la realisation ne sest accentuee que ces dernieres annees chez les patients en milieu de reanimation pour indications divers, dont le syndrome de detresse respiratoire est la principale. Cette manÅ“uvre est realisee dans le but dameliorer Ã court terme la fonction respiratoire chez les patients en SDRA. Pour cela, a ete realisee notre etude qui est une etude prospective dune duree dune annee, portant sur 33 cas, au sein du service de reanimation urgences chirurgicales du centre hospitalier universitaire Avicenne de Rabat. Cette etude a eu comme conclusion que le decubitus ventral ameliore la fonction motrice, ainsi que les compliances pulmonaires.Il a ete prouve que le deces des patients navait aucun rapport avec le decubitus ventral, les complications aussi survenant lors du DV netaient pas en correlation avec le deces. Aucune atteinte hemodynamique ni respiratoire na ete prouvee suite au DV. Outre, notre etude a mis le point sur limportance majeure de la premiere seance, qui presentait les meilleurs resultats, la duree quant Ã elle etait en correlation direct en ameliorant la fonction respiratoire. Par contre, cette etude reste limitee sur le plan echantillon, qui etait heterogene, en plus les patients nont pas tous beneficie du meme nombre de seances et de la meme duree de seance vu quelles etaient parfois interrompue suite aux complications survenant en cours du DV.
Objetos de arte mueble y funcionales del Magdaleniense inferior e inicial de la Cueva del Mirón (Ramales de la Victoria, Cantabria, España) ligados al Procesamiento del Ocre
Authors: González Morales Manuel R. , Rivero Vilá Olivia , Straus Lawrence G.
Published: December 2022

Presentamos documentación y análisis detallados de un nódulo de ocre con una retícula grabada, un fragmento de ocre con incisiones profundas y un abrasionador de cuarcita con restos de ocre procedentes de los niveles del Magdaleniense inferior e inicial de la Cueva del Mirón. Estos objetos se añaden al inventario de hallazgos notables de los depósitos de este periodo en el yacimiento, y muestran la importancia de las actividades ligadas al procesamiento del ocre y la posible transformación simbólica de un instrumento técnico mediante decoración. El ocre en las formas de polvo y en trozos es abundante en los niveles magdalenienses y fue utilizado para teñir los huesos de “la Dama Roja” y la cara contigua al enterramiento del gran bloque que parece “marcar” la tumba en el Magdaleniense inferior.
Radioterapia śródoperacyjna z wykorzystaniem elektronów
Authors: Graczyk Kinga , Kruszyna-Mochalska Marta , Kijeska Weronika
Published: December 2022

Taktyki leczenia, które łączą ze sobą oszczędzającą operację chirurgiczną z radioterapią stały się standardem w leczeniu wczesnych nowotworów. Jednym z przykładów skojarzonego leczenia jest wykonanie radioterapii śródoperacyjnej, którą przeprowadza się w trakcie zabiegu chirurgicznego, gdy pacjent nadal znajduje się pod anestezją w sterylnej sali operacyjnej. 

Celem pracy jest omówienie techniki radioterapii śródoperacyjnej wykorzystującej wiązkę elektronów (IOERT) generowaną przez mobilne akceleratory. 

Metoda IOERT znajduje swoje zastosowanie w leczeniu nowotworów takich lokalizacji jak: pierś, prostata, trzustka, okrężnica i odbytnica. Na podstawie doniesień literaturowych omówione zostało: przebieg procedury, najczęściej stosowane parametry fizyczne oraz wyzwania związane z kontrolą jakości i ochroną radiologiczną personelu.
Register Analysis Study of the Korean Simultaneous-Occurrence Suffixes ‘-eumyeo’ and ‘-eumyeonseo’
Authors:   Dong Nam Eo-Mun-Hak-Hoi, Baek Jae-Pa
Published: December 2022

This study aims to determine the distribution by register of the verbal suffixes -eumyo (-으며) and -eumyeonseo (-으면서) ‘while, during’ indicating simultaneous occurrence. To this end, a standard corpus was developed based on the Sejong corpus, and the distributions of the two forms by spoken/written and formal/informal speech registers were analyzed. The loglikelihood ratio (G2) values were then used to verify the statistical significance of the distributional differences. The results show that -eumyo is predominantly used in speaking (G2 = 2301.66), while -eumyeonseo is widely used in both spoken and written registers, though it is more common in the latter (G2 = 39.97). Both -eumyo and -eumyeonseo occurred more frequently in the formal speech register, although the difference was smaller for -eumyo (G2 = 29.47) than in writing, while the difference for -eumyeonseo was statistically insignificant (G2 = 0.95). This study allows objective conclusions to be drawn regarding similar grammatical items that have received conflicting explanations and is significant in showing the value of register analysis and depiction methods.
Endometriosis Painful Symptoms and its Relationship with Quality of Life
in Women Referring to Educational Centers of Tabriz University of Medical
Sciences
Authors: Alizad Sevda , Mirghafourvand Mojgan , Oskouei Behnaz Sadeghzadeh , Bani Soheila
Published: December 2022

Background:

Endometriosis is one of the most frequent illnesses and is connected with
substantial problems, such as pain and reduced social function.

Objective:

This study aimed to examine the association between painful endometriosis symptoms and
women's quality of life.

Methods:

This research included 169 endometriosis patients. Data was collected using sociodemographic,
ENDO PAIN- 4D, and EHP-30 questionnaires. To examine the relationships between
pain symptoms and quality of life, the Pearson correlation test was performed. Also, the general linear
model with controlling the probable confounding variables was used for multivariate analysis.

Results:

The mean (SD) of the overall ENDOPAIN 4D and the overall EHP 30 scores were 66.0
(61.0), and 35.9 (22.4), respectively. In terms of quality of life, the emotional domain had the greatest
42.0 (20.3), and the pain domain had the lowest mean score 7.2 (4.5). The total score of EHP 30 and
ENDOPAIN 4D had a substantial positive connection (r = 0.55 and p > 0.001). With an increasing
ENDOPAIN 4D score, the quality-of-life score increased (B = 0.2; CI: 95 %: 0.1 to 0.2). Explaining
that in the EHP-30 scale, the quality of life worsens as the score increases.

Conclusion:

This study found that the more intense the painful symptoms of endometriosis, the poorer
the quality of life. Thus, it is vital to lessen the painful symptoms and practice self-care to enhance
these patients' quality of life.
Nalbuphine Suppresses Leukemia Stem Cells and Acts Synergistically with Chemotherapy
Drugs via Inhibiting Ras/Raf/Mek/Erk Pathway
Authors: Dan Jiapeng , Xiao Jinliang , Wang Weilian
Published: December 2022

Aims:

Retrospective clinical studies have shown that opioids could potentially affect the risk of cancer recurrence and metastasis. Better understanding of the effects of opioids on cancer will help to select the optimal anesthetic regimens to achieve better outcomes in cancer patients.

Background:

Increasing evidence has shown the direct effects of opioids on bulk cancer cells and cancer stem cells. Opioid such as nalbuphine is approved to control cancer-associated pain but little is known on their possible cancer effects.

Objective:

To assess the biological effects of nalbuphine on acute myeloid leukemia (AML) differentiated and stem/progenitor CD34+ cells.

Method:

AML CD34+ cells were isolated with colony formation, growth and apoptosis assays performed. Biochemical and immunoblotting analyses were conducted in AML cells exposed to nalbuphine.

Result:

Nalbuphine at clinically relevant concentrations was active against a panel of AML cell lines with varying IC50. Importantly, nalbuphine augmented the efficacy of cytarabine and daunorubicin in decreasing AML cell viability/growth. Besides bulk AML cells, we noted that nalbuphine was effective and selective in decreasing viability and colony formation of AML CD34+ cells while sparing normal hematopoietic CD34+ cells. The action of nalbuphine on AML cells is not associated with opioid receptors but via inhibiting Ras/Raf/MEK/ERK signaling pathway. Overexpression of constitutively active Ras partially but significantly reversed the inhibitory effects of nalbuphine on AML cells.

Conclusion:

Our findings reveal the selective anti-AML activity of nalbuphine and its ability in inhibiting Ras signaling. Our work suggests that nalbuphine may be beneficial for leukemia patients.
In vitro and In vivo Investigations on Anti-Hyperuricemic Activity of
Commercial Preparations of Persicaria minor (Biokesum®) and Eurycoma
longifolia (Physta®)
Authors: Chinnappan Sasikala M. , George Annie , Choudhary Yogendra Kumar , Godavarthi Ashok , Teng Chi-Ling , Jin Wong Hoi
Published: December 2022

Background:

Eurycoma longifolia Jack (Simaroubaceae) root extracts and Persicaria
minor Huds. (Polygonaceae) leaf extracts are known to exhibit antioxidant activity, while their antihyperuricemic
effects remain unclear.

Objective:

The objective of this study is to investigate the anti-hyperuricemic activity of Biokesum®
(extract of P. minor) and Physta® (extract of E. longifolia).

Methods:

In vitro anti-hyperuricemic activity for Biokesum® and Physta® was measured by xanthine
oxidase inhibition based on a biochemical enzymatic assay at concentrations of 1, 10, and 100
μg/mL. In vivo anti-hyperuricemic activity was assessed in potassium oxonate-induced hyperuricemia
Sprague-Dawley rat model. Biokesum® at doses of 100, 300, and 500 mg/kg and Physta® at
doses of 300 and 500 mg/kg were administered for 7 days to the hyperuricemic rats. Serum uric acid
was measured on days 0, 1, 3, and 7, and liver xanthine oxidase activity was measured on day 8.
Allopurinol was used as positive control in both in vitro and in vivo investigations.

Results:

Based on xanthine oxidase biochemical enzymatic assay, IC50 of Biokesum® and Physta®
were 88.6 μg/mL and > 100 μg/mL respectively. In hyperuricemic rats, Biokesum® and Physta®
significantly reduced the serum uric acid by 5.6% and 5.5% respectively at 300 mg/kg (p < 0.05)
and 9.8% and 9.0% respectively at 500mg/kg (p < 0.001) compared to untreated rats. Significant
liver xanthine oxidase inhibition at 37.5% and 34.1% were observed in rats treated with Biokesum®
and Physta® respectively.

Conclusion:

The study has demonstrated hyperuricemic activity of Biokesum® and Physta®, clinical
studies in hyperuricemia-related diseases population are required to further confirm the activity.
A construção da imagem do funcionário público brasileiro: uma análise crítico-discursiva de artigos de opinião do jornal Gazeta do Povo
Authors: Trigo Mára Rubio
Published: December 2022

The theme of this research is the discourse referring to public servants in two opin-ion articles published by Gazeta do Povo newspaper in 2017 and 2020. The general objective is investigate how the image of Brazilian civil servants is constructed, discursively, in opinion arti-cles. The specific objectives are to investigate how lexical choices, the use of metaphors and the semantic meaning of the lexicon build the image of these workers. This is a qualitative research, of an interpretive nature, which has in the selected opinion articles the direct source of the data to be interpreted. The analysis work is based on theoretical assumptions for ACD, by Van Dijk (2018), based on the socio-cognitive line, based on the discourse-cognition-society triad, elements that are in a constitutive relationship and play important role in the production and understanding of discourses. We concludeis that the lexical choices, metaphors and imagery resources that build the lo-cal and global meanings of the discourses, materialize ideologies and social practices that constitute the mental model of public servants of their, authors and the defamatory and stereotyped nature of the articles make a predominantly negative consensus regarding the public servants.
Discurso bolsonarista ou nazista? A materialidade discursiva em charges
Authors: Vieira Isabela Rodrigues , Ramos Paulo
Published: December 2022

Throughout the government of Brazilian President Jair Messias Bolsonaro, there are several mentions that associate the presidential figure with a Nazi discourse due to some of his positions. According to Pêcheux (1988), the ideological instances are responsible for determining the images projected into society from a social and historical context. Like the news and reports, the cartoons have addressed several features that relate Bolsonaro’s discourse as belonging to Na-zism. Although it is not, for the most part, a direct mention, the ideological instances materialize this discourse through non-verbal language, that is, through the symbol of the swastika. Thus, this article aims to expose how cartoons used this resource to allude to the Nazi discourse linked to the Bolsonaro government. For this, we will select three graphic texts that go through the same Ideo-logical Formation and go through similar discursive foramisions. For methodological purposes, we will analyze cartoons that were published between January and May 2020, for being inserted within the same context and presenting a similar discourse. For the analysis, we start from the studies of the French Discourse Analysis.
Análise dialógica do discurso: apontamentos de/para pesquisa no Brasil
Authors: Acosta Pereira Rodrigo , Oliveira Amanda Maria de
Published: December 2022

Different approaches to the study of discourse have been consolidated in the fields of Linguistics and Applied Linguistics. Among several, a responsive approach to the dialogical per-spective of Bakhtin’s writings and the Circle has mobilized several studies, especially in Brazil, un-der the name of Dialogical Analysis of Discourse (DDA). Under this scenario, the objective of this article is to map research and re-state some of the fundamental questions about DDA in the field of Brazilian discursive studies. To do so, we mapped studies in Brazilian institutional databases and resumed foundational considerations from the writings of M. Bakhtin and the Circle and from contemporary scholars who have responded to these writings with investigations associated with the DDA. We believe in the relevance of the discussion since it contributes to a mapping of research in the field, and, therefore, contributes to the consolidation of DDA as a field of study compared to other approaches to studies in the discursive field. In addition, the present research collaborates to open space for discussions on DDA in the fields of Social Sciences and Humanities, which seek, among other issues, reflections on the subject, society, and languages.
A repetição como estratégia retórico-manipulativa no texto de autoajuda
Authors: Matos Janaica Gomes , Muniz Mário Junglas , Pereira Sarahn Maria de Sousa
Published: December 2022

The present work aims to establish the relationship between text, discourse and rhet-oric, identifying and discussing the strategic marks of the use of repetition, in the construction of manipulative meanings in the self-help text, from a sociocognitive-discursive perspective. Thus, we present the resource of repetition, which we associate with the mobilization of pathos in self-help To this end, we theoretically rely on Koch (2004) and Koch and Elias (2016) to address the functions of repetition in the text; Cavalcante et alii (2020) and Amossy (2008) to substantiate the relationship between text and argumentation in discourse; Breton (1999) and Charaudeau (2009; 2010) to ad-dress the manipulation of affects and repetition. Methodologically, this research presents a qualita-tive, descriptive and documentary approach, with an analysis of self-help works. As a result, several paraphrased ideas were found to be combined simultaneously with other repetition strategies in the sequencing of the chapters of the works, such as syntactic parallels and lexical and sound reitera-tions, added to other linguistic-discursive resources which we relate to pathemic meaning effects. and with the possibilities of manipulation of the subject-reader of self-help
A formação discursiva e a construção do ethos no discurso de vitória de Kamala Harris
Authors: Medeiros Rivanda
Published: December 2022

This article aims at making a qualitative analysis of a political discourse: the victory speech of the candidate elected to the vice-presidency of the United States of America, in the 2020 elections, Kamala Harris. The discursive formation of her statement will be identified, as well as the discursive strategies that the speaker used to create her ethos, the construction of her image of cred-ibility, as well as the means by which she tries to preserve this created image. The selected analysis corpus was obtained from an official video of Harris’ first statement after the election results, on the American television channel NBCNews, recorded on November 8, 2020. Discourse Analysis through techniques based on the postulates de Charaudeau (2006a, 2006b, 2011) and Maingueneau (2005) were the theoretical and methodological contribution to the undertaken study.
Liber Amicorum Benedita Mac Crorie Volume II
Authors: Oliveira A. Sofia Pinto
Published: December 2022

Existe uma tradição académica – nacional e internacional - que consiste em assinalar os acontecimentos mais marcantes com a publicação de obras coletivas, em que nos associamos por um qualquer propósito comum. O propósito deste Liber Amicorum é o de homenagear uma docente e investigadora da Escola de Direito da Universidade do Minho, que trabalhou 21 anos na instituição, reunindo grande admiração da comunidade académica. Nele se reúnem trabalhos de Colegas, da UM e de outras Academias, centrados na área dos direitos fundamentais – sob perspetivas diversas – em diálogo com a obra de Benedita Mac Crorie.
Nueva información del perfil de compuestos bioactivos, potencial antioxidante y antiproliferativo de Parkinsonia praecox (Fabaceae)
Authors: López-Romero Julio Cesár , Torres-Moreno Heriberto , Valencia-Rivera Dora Edith , Leyva-Peralta Mario Alberto , Lugo-Sepúlveda Ramón Efraín , Robles-Zepeda Ramón Enrique , Rodríguez-Martínez Karen Lillian , Villegas-Ochoa Mónica Alejandra , Salazar-López Norma Julieta , González-Aguilar Gustavo Adolfo
Published: December 2022

Antecedentes y Objetivos: Parkinsonia praecox,“palo brea”, es una planta medicinal distribuida en el Desierto de Sonora en México. Sin embargo, existe poca información acerca de la composición química y del potencial biológico de esta planta. Basado en lo anterior, el objetivo del presente estudio fue determinar la composición química y el potencial antioxidante y antiproliferativo de P. praecox. Métodos: Se prepararon extractos metanólicos de tallos (PPS), frutos (PPB) y flores (PPF). La composición química se determinó a través de los métodos de perfil fitoquímico, Folin-Ciocalteu y UPLC-DAD. La actividad antioxidante se evaluó por los métodos DPPH, ABTS, ORAC y FRAP. La actividad antiproliferativa se determinó por el ensayo MTT contra las líneas celulares A549 (cáncer de pulmón de células no pequeñas), MDA-MB-231 (cáncer de mama triple negativo), PC-3 (cáncer de próstata grado IV), HeLa (cáncer de cervix) y L929 (tejido conectivo subcutáneo no canceroso). Resultados: El perfil fitoquímico mostró la presencia de terpenos, compuestos fenólicos, flavonoides, taninos y azúcares en los extractos. PPS presentó la concentración más elevada (p<0.05) de compuestos fenólicos (65.5 mg GAE/g), identificando y cuantificando quercetina (218.86 µg/g). Además, PPS mostró la capacidad más elevada (p<0.05) para estabilizar a los radicales DPPH (IC50: 137 µg/ml), ABTS (39.56 µM TE/g), hidroxilo (ORAC: 1777.78 µM TE/g), y reducir metales (FRAP: 935.6 µM Fe(II)/g). Un comportamiento similar se observó en la actividad antiproliferativa, ya que PPS mostró la citotoxicidad más elevada (p<0.05): A549 (IC50: 341.3 µg/ml), MDA-MB-231 (IC50: 147.3 µg/ml), PC-3 (IC50: 78.8 µg/ml), HeLa (IC50: 121.6 µg/ml) y L929 (IC50: 93.29 µg/ml).Conclusión: Este es el primer estudio donde se reporta el perfil de compuestos bioactivos y el potencial biológico de P. praecox. Los resultados muestran una fuerte asociación entre la actividad antioxidante y antiproliferativa con la presencia de compuestos fenólicos. Esto representa un potencial soporte para el desarrollo de terapias farmacológicas.
Evaluación financiera de la producción in vitro de árboles de olivo con opciones reales
Authors: Perea-Gómez Lorena , García-Salazar José Alberto , López-Reyna María del Carmen , Arellano-Ostoa Gregorio
Published: December 2022

Los proyectos para establecer empresas biotecnológicas son difíciles de evaluar porque se encuentran en escenarios de riesgo e incertidumbre. El objetivo de este trabajo fue evaluar la viabilidad financiera de un laboratorio comercial de cultivo in vitro para propagar árboles de olivo (Olea europaea L.). El proyecto se evaluó con el método de análisis financiero a través del cálculo de indicadores como el valor actual neto (VAN), la tasa interna de retorno (TIR), la tasa de actualización (TREMA) y la relación beneficio costo (B/C), y con el enfoque de opciones reales utilizando arboles binomiales. Este último método consideró la volatilidad de precio del producto y la probabilidad de éxito de cada una de las cinco etapas (establecimiento, multiplicación, enraizamiento, aclimatación y vivero) del proyecto. Los resultados obtenidos en el análisis financiero indicaron que el proyecto se rechazó pues el VAN fue de MXN -1 498 656, la TIR fue de 13%, la TREMA de 25% y la B/C de 0.83. Los resultados de la evaluación con el método de opciones reales indican que cada una de las cinco etapas del proyecto se podría llevar a cabo en los dos escenarios analizados, ya que el VAN total fue positivo en cada etapa y, además, el valor de la etapa siguiente fue mayor al valor de la anterior. Con este método se pudo determinar el valor real del proyecto y el momento oportuno de abandonarlo; por lo tanto, se recomienda a los inversionistas utilizarlo al momento de tomar decisiones en inversiones de alto riesgo de proyectos biotecnológicos.
Ethanol Oxidation on Gold Nanowire Containing Oxygen Impurities: A Study by Ab Initio Molecular Dynamics Simulations
Authors: Bueno Otto , San-Miguel Miguel , da Silva Edison
Published: December 2022

Linear atomic chain (LAC) gold nanowires (Au-NWs) containing oxygen impurities are materials that could be used as supports to stimulate chemical reactions. Its peculiar structural characteristics, such as abnormal Au-Au bonds, make it interesting to explore the chemical reactions of this material at a theoretical level. This work investigated the chemical reaction of ethanol supported on Au-NW containing two oxygen impurities. Using ab initio molecular dynamics simulations, it was shown that the presence of oxygen impurity in the LAC conditions the minimum energy paths (MEP) that ethanol will follow in its chemical transformation. When the structure of the LAC contains two oxygen impurities, the formation of acetaldehyde and acetic acid as reaction products were observed. Specifically, the presence of two oxygen impurities in the LAC favors the migration of hydrogens of the -CH2- and -OH groups of ethanol towards the LAC. In addition, it was observed that the formation of the C-O bond was favored, which implies an additional reaction intermediate that leads to a total of two different reaction paths in ethanol oxidation.
Response of buckthorn seedlings to foliar spraying with Kelamyth Fe and algae mixture on vegetative growth traits for cultivar AL-Tafahi.
Authors: Hashash El- Hamdani Hajer Ismaeel , AL-Ali Hameed H.
Published: December 2022

This study was done in the lath house of the Horticulture and Gardening Dept. / College of Agriculture / University of Anbar during the growth season 2021 to study the effect of leaf spraying kelamyth chelated Fe in three levels (0, 50, 100 mg.L-1), with three levels Alga Mix of (0, 1, 1.5 g.L-1) and their interaction on vegetative growth traits and leaf content of minerals for buckthorn seedlings AL-Tafahi cultivar. The results showed that the interaction between chelated kelamitic Fe and F2S2 algae mixture at a concentration (100 mg.L-1 kelamitic Fe + 1.5 g.L-1 algae mixture) had given a significant increase in plant height, number of branches, leaf area, chlorophyll, carbohydrates, Fe and saponins. Successively with values (75. 057cm, 19.183 units.seedling-1, 23.833cm2, 41.537 mg. g-1 fresh weight, 3.800%, 194.000 ppm, 1.545 c.ml-1), compared to control treatments.

Keywords: Ziziphus mauritiana, chelated iron, seaweed extract, foliar spraying, Buckthorn.
The relationship between the infestation of Whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) and the chlorophyll content in different Eggplant varieties
Authors: Raed Amina , Ahmed Qasim , Abdulsattar Arif Mokhtar
Published: December 2022

The sweet potato whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae), is one of the most important pests in vegetables. Although the host plant Solanum melongena, is considered the most preferred, the whiteflies have preferences for particular varieties of eggplant. In this study, we evaluated three eggplant varieties in choice feeding tests. We found that the varieties of Zomorrod and Barcelona were the most preferred with the highest numbers of whitefly nymphs, which were 312 and 300 per leaf, respectively, on the last week of May. In comparison, the nymph average was 171.8 per leaf on the last week of May on the kareema. Chlorophyll concentration has been negatively affected by the infestation of B. tabaci. The investigation of the chlorophyll content ratio between the uninfested and infested eggplant leaves showed a decrease in chlorophyll content at 13.95 and 6.60 11 mg/L of the Zumorrod variety for the uninfested and infested leaves, respectively, with 52.67% chlorophyll reduction. At the same time, the mean chlorophyll content for uninfested and infested eggplant leaves of the Barcelona variety was 12.74 and 4.95 mg/L, respectively, with 61.14% chlorophyll reduction. At the same time, the Kareema variety was recorded at 17.49 and 4.95 mg/L for the uninfested and infested leaves, respectively, with 72.39% chlorophyll reduction. Furthermore, feeding by B. tabaci reduced leaf photosynthesis in eggplant by restricting gas exchange through stomata and reducing chlorophyll's content and photosynthetic capacity.

Keywords: population density; piercing pest; Bemisia tabaci; Solanum melongena; host preference; plant pigments
Efecto de los hongos formadores de micorriza arbuscular (HFMA) en la producción de aceites esenciales en romero (Rosmarinus officinalis L.)
Effect of arbuscular mycorrhizal fungi (AMF) on essential oil production in rosemary (Rosmarinus officinalis L.).
Authors: Sierra-Escobar Jorge A. , Márquez Arteaga Manuela , Quiroz Clara
Published: December 2022

An experimental greenhouse campaign was conducted to evaluate the effect of arbuscular mycorrhizal fungi (AMF) on the production of essential oils in rosemary (Rosmarinus officinalis L.). For effect, a completely randomized experimental design was implemented, with three treatments composed of soil plus multisporic inoculum (Glomus spp, Acaulospora spp, Entrophosfora spp, Scutellospora spp.), soil plus monosporic inoculum (Entrophosfora colombiana), and the control treatment without inoculation, all of these with ten replicates per treatment. The soil used for all experimental units was sterilized and adjusted to 0.02 mg L-1 of P (phosphorus), the optimum concentration for the mycorrhizal condition. The response variables were: foliar P content, aerial dry mass, mycorrhizal colonization, and essential oil yield. The results of aerial dry mass indicate significant increases in the inoculated treatments compared to the control treatment. Leaf P showed no differences between treatments. The average mycorrhizal colonization of the inoculated treatments was 73%. As for the essential oils produced by the rosemary plants, the results were the inverse of those of the mass, where a higher yield was found in the control treatment. According to the data, the use of HFMA in the production of rosemary favors the development of the plant; on the other hand, the yield of essential oils could be compensated by the higher biomass produced, which would allow producers to increase the amount of oil extracted.

Keywords: essential oils, arbuscular mycorrhizal fungi, Rosmarinus officinalis.
Computational discovery of novel anthelmintic natural compounds from Agave Brittoniana trel. Spp. Brachypus
Authors: González-Castañeda Yeniel , Marrero-Ponce Yovani , Guerra Jose O. , Echevarría-Díaz Yunaimy , Pérez Noel , Pérez-Giménez Facundo , Simonet Ana M. , Macías Francisco A. , Nogueiras Clara M. , Olazabal Ervelio , Serrano Hector
Published: December 2022

Helminth infections are a medical problem in the world nowadays. This report used bond-based 2D quadratic indices, a bond-level QuBiLs-MAS molecular descriptor family, and Linear Discriminant Analysis (LDA) to obtain a quantitative linear model that discriminates between anthelmintic and non-anthelmintic drug-like organic-compounds. The model obtained correctly classified 87.46% and 81.82% of the training and external data sets, respectively. The developed model was used in a virtual screening to predict the biological activity of all chemicals (19) previously obtained and chemically characterized by some authors of this report from Agave brittoniana Trel. spp. Brachypus. The model identified several metabolites (12) as possible anthelmintics, and a group of 5 novel natural products was tested in an in vitro assay against Fasciola hepatica (100% effectivity at 500 µg/mL). Finally, the two best hits were evaluated in vivo in bald/c mice and the same helminth parasite using a 25 mg/kg dose. Compound 8 (Karatavinoside A) showed an efficacy of 92.2% in vivo. It is important to remark that this natural compound exhibits similar-to-superior activity as triclabendazole, the best human fasciolicide available in the market against Fasciola hepatica, resulting in a novel lead scaffold with anti-helminthic activity.
Keywords: TOMOCOMD-CARDD Software; QuBiLs-MAS, nonstochastic and stochastic bond-based quadratic indices; LDA-based QSAR model; Computational Screening, Anthelmintic Agent; Agave brittoniana Trel. spp. Brachypus, Fasciola hepatica.
Current situation of snakebites envenomation in the Neotropics: Biotechnology, a versatile tool in the production of antivenoms.
Authors: Romo Elizabeth , Torres Marbel , Martin-Solano Sarah
Published: December 2022

Snakebite envenomation is a neglected tropical disease that affects millions of people around the world with a great impact on health and the economy. Unfortunately, public health programs do not include this kind of disease as a priority in their social programs. Cases of snakebite envenomations in the Neotropics are inaccurate due to inadequate disease management from medical records to the choice of treatments. Victims of snakebite envenomation are primarily found in impoverished agricultural areas where remote conditions limit the availability of antivenom. Antivenom serum is the only Food and Drug Administration-approved treatment used up to date. However, it has several disadvantages in terms of safety and effectiveness. This review provides a comprehensive insight dealing with the current epidemiological status of snakebites in the Neotropics and technologies employed in antivenom production. Also, modern biotechnological tools such as transcriptomic, proteomic, immunogenic, high-density peptide microarray and epitope mapping are highlighted for producing new-generation antivenom sera. These results allow us to propose strategic solutions in the Public Health Sector for managing this disease.

Keywords: antivenom, biotechnology, neglected tropical disease, omics, recombinant antibody.
Risk factors for tuberculosis: An umbrella review of meta-analyses (Preprint)
Authors: Wu Ya , Luo Ji , Gao Lijie , Zou Fengjuan , Jian Ronghua , Jin Yingying , Zhu Sui
Published: December 2022

BACKGROUND

Numerous studies have identified multiple risk factors for tuberculosis (TB). We conducted an umbrella review of meta-analyses to consolidate the available epidemiologic evidence and evaluate its credibility.

OBJECTIVE

The main objective of our study was to systematically consolidate the available risk factors of TB and thus provide a reference for future TB prevention and control.

METHODS

We searched PubMed, Web of Science and the Cochrane Database of Systematic Reviews for meta-analyses on factors influencing TB published between database inception and October 17, 2021. The summary effect, 95% confidence interval (CI) and heterogeneity were obtained. A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR2) was applied to assess the methodological quality.

RESULTS

A total of 17 eligible articles were included in this umbrella review. A total of 24 risk factors, including lifestyle and hygiene, basic personal characteristics, nutrients, vaccinations and other disease factors, were identified. Among these, moderate-quality evidence suggested that indoor air pollution (relative risk [RR], 1.26; 95% CI: 1.08, 1.48), underweight (RR, 4.96; 95% CI: 4.87, 5.05), vitamin D deficiency (odds ratio [OR], 1.48; 95% CI: 1.04, 2.10) and diabetes (OR, 2.3; 95% CI: 2.0, 2.7) increase the risk of TB. Another 17 factors associated with increased risk and 2 factors associated with reduced risk with weak credibility were identified.

CONCLUSIONS

The findings of our study can provide a reference for future TB prevention and control and for clinicians to make medical decisions. Nonetheless, large, multicenter, and multicountry prospective studies are warranted to confirm the results of this umbrella analysis.

CLINICALTRIAL

PROSPERO CRD42021255786; https://tinyurl.com/54d9pxy8
Inverse-forward method for heat flow estimation: case study for the Arctic region
Authors: Petrunin Aleksey , Soloviev Anatoly , Sidorov Roman , Gvishiani Alexei
Published: December 2022

The heat flow data are important in many aspects including interpretation of various geophysical observations, solutions of important engineering problems, modelling of the ice dynamics, and related environmental assessment. However, the distribution of the direct measurements is quite heterogeneous over the Earth. Different methods have been developed during past decades to create continuous maps of the geothermal heat flow (GHF). Most of them are based on the principle of similarity of GHF values for the lithosphere with comparable age and tectonic history or inversion of magnetic field data. Probabilistic approach was also used to realize this principle. In this paper, we present a new method for extrapolating the GHF data, based on the inversion of a geophysical data set using optimization problem solution. We use the results of inversion of seismic and magnetic field data into temperature and data from direct heat flow measurements. We use the Arctic as the test area because it includes the lithosphere of different ages, types, and tectonic settings. In result, the knowledge of GHF is important here for various environmental problems. The resulting GHF map obtained well fits to the observed data and clearly reflects the lithospheric domains with different tectonic history and age. The new GHF map constructed in this paper reveals some significant features that were not identified earlier. In particular, these are the increased GHF zones in the Bering Strait, the Chukchi Sea and the residual GHF anomaly in the area of the Mid-Labrador Ridge. The latter was active during the Paleogene.
Adopting Incremental Innovation Approaches in the Digitalization of Village Government Services
Authors: Ahmad Jamaluddin
Published: December 2022

Although much research has established the importance of digitalization in public services, in practice, village governments responsible for village community services often obscure public perceptions about the potential impact on digital-based public services. This study aims to provide a more detailed picture of the incremental innovation approach in  the implementation of public services, especially the adoption of digital technology in  the delivery of village government service. This research is  a case study research that uses a qualitative research design. study results underline the importance of the incremental innovation approach. Digitalization impacts public perceptions about transparency, speed, and accountability; willingness to accept changes, especially changes in the use of mobile phones (mobile phones) as needed; and  resultant   social impact. Thus, study results are an invaluable input into the decision-making process related to public services.