bluuebunny/crossref_metadata_2025 huggingface dataset:
Assistência de Enfermagem ao recém-nascido prematuro e à família: uma revisão integrativa
Authors: Strauss Eloísa Vanessa , Antoniolli Nelissandra Cristiane Scorsato
Published: February 2025

Introdução: A prematuridade é uma condição que exige cuidados especializados e uma abordagem multidisciplinar para garantir a sobrevida e o desenvolvimento adequado do recém-nascido. Objetivo: O objetivo deste trabalho é identificar as ações assistenciais de enfermagem para o recém-nascido prematuro (RNPT) e sua família em uma Unidade de Terapia Intensiva Neonatal (UTIN). Métodos: A metodologia utilizada foi a revisão integrativa da literatura, sendo coletados dados na Biblioteca Virtual em Saúde (BVS) e suas respectivas bases de dados. A pesquisa inicial resultou em 56 artigos, dos quais, após a aplicação dos critérios de inclusão e exclusão, foram selecionados 15 para análise. Os achados foram organizados em quatro tópicos principais, que fundamentaram o discorrer do estudo: conceitos, causas e epidemiologia da prematuridade; direitos e dificuldades enfrentadas pelas famílias durante a internacionalização; o apoio à família e a promoção do vínculo afetivo; e os cuidados prestados aos recém-nascidos na UTIN. Resultados: O estudo evidenciou que a prematuridade influencia tanto a saúde dos recém-nascidos quanto a dinâmica e rotina familiar, sublinhando a relevância de cuidados humanizados que incluem a participação da família e fortalecem o vínculo com o bebê. Conclusão: Conclui-se que a capacitação contínua da equipe de enfermagem é essencial, considerando a relevância dos cuidados especializados, uma vez que os profissionais de saúde desempenham um papel vital na implementação de práticas que não apenas garantem a saúde física do RNPT, mas também promovem o bem-estar emocional da família, contribuindo para melhores desfechos clínicos.
Code Mixing Found in the Leonardo’s Podcast with Satria Mahatir
Authors: Permata Made Goutamayasa , Sulatra I Komang
Published: February 2025

Nowadays, the use of two or more languages social media is a common phenomenon. This study aims to find out the types of Code Mixing in The Leonardo’s Podcast with Satria Mahatir and to analyze the reason of the usage of code mixing on The Leonardo's Podcast with Satria Mahatir. The data source of this study is The Leonardo's podcast with Satria Mahatir. This research method includes descriptive qualitative by means of observation, watching, and writing the utterances with code mixing data. The theory used in analyzing the data is according to Muysken (2000). The results of the findings, found that the type of code mixing are insertion, alternation, and congruent lexicalization. In the research carried out by the researcher, the number of code mixing found were 44 data which include insertion code mixing 40 data, alternation code mixing 3 data, and congruent lexicalization only 1 data. Insertion is used dominantly in the data source due to the lack of word equivalents and the influence of local prestige culture that can cause this to happen.
Spatial Probit Regression Analysis Using Recursive Importance Sampling on the Human Development Index in Central Jawa Province
Authors: Solekha Novia , Nisa Nabilla Rida Tri
Published: February 2025

This research aims to analyze the Human Development Index (HDI) in Central Java Province using two modeling approaches: the probit model and the spatial probit model. HDI, a crucial indicator of quality of life, is categorized into two groups: medium-low and high. Among the 35 districts and cities in Central Java, 9 fall into the medium-low category (35%), while 26 are classified as high (65%). Brebes Regency has the lowest HDI at 69.54, whereas Sukoharjo City boasts the highest HDI at 77.73. The results reveal that the spatial probit model provides a superior classification of HDI compared to the probit model. The mapping of prediction results highlights the discrepancies between actual and predicted HDI categories. This study underscores the advantage of incorporating a spatial approach, enhancing the accuracy of HDI analysis, and offering a more nuanced understanding of spatial distribution and dependencies in human development within Central Java. Further research is recommended to include additional variables, such as poverty levels or access to education, which spatial factors may also affect. Moreover, this method can be applied to other regions or enhanced using more complex spatial models, such as spatial autoregressive (SAR) or geographically weighted regression (GWR), for deeper and more comprehensive analysis.
A feasibility study of shell fusion technology application in jewelry design
Authors: Nuernberg Gustavo George Verdieri , Côcco Lílian Cristina , Cunico Marlon Wesley Machado
Published: February 2025

In recent times, to cater to a larger audience, mass production has become more common, with investment casting being one of the fastest-growing manufacturing techniques. However, even with this modernization, production still requires significant manual labor, such as mold assembly, heating, gas removal, cutting, and polishing. This process also consumes a lot of energy and generates waste. Rapid prototyping and computer-aided design technologies have revolutionized jewelry manufacturing, enabling greater agility, reduced production time, and product customization, while also offering designers more creative freedom. This study aims to present shell fusion technology (SFT), an advanced digital manufacturing technology, as a way of processing jewelry and other precious metals for various applications. Practical processing tests were carried out using SFT. Metallic materials with high and low melting points were employed, enabling the investigation of processing characteristics (temperature, heating rate, and melting time), final quality (flaws, roughness, etc.), finishing requirements, and other factors. The feasibility of making jewelry and metal parts using SFT was investigated and validated. This work demonstrates that SFT can be used to make jewelry and process noble metals for other purposes. A piece of jewelry was produced with a quality classified as satisfactory for use as an ornament.
The impact of benzodiazepine use on treatment retention in opioid agonist treatment: A literature review
Authors: Lawrence Caitlin , McLellan-Carich Rachel , M. Barr Alasdair
Published: February 2025

It is well established that there is an elevated overdose risk with benzodiazepine (BZD) use during opioid agonist treatment (OAT). However, further studies regarding other aspects of how BZDs influence OAT are necessary. This review summarizes the literature on concurrent BZD use with medications for opioid use disorder (MOUD) and how they affect treatment retention in OAT. EMBASE (Ovid), PubMed, and Google Scholar database search tools were used to search for studies that examined the effect of concurrent BZD and MOUD on treatment retention in OAT. Studies published up to January 30th, 2024, were included with no restriction applied other than English language. The criteria for included literature were the presence of both BZD and at least one MOUD as a variable and treatment retention or MOUD adherence as an outcome. Fourteen articles met the criteria for review: eleven retrospective studies and three observational studies. Methadone was utilized in seven studies, buprenorphine in five, naltrexone in one, and suboxone (buprenorphine + naloxone) in one study. The included studies indicated that when BZDs are taken as prescribed and for shorter periods in conjunction with OAT, subjects are retained in their MOUD programs just as well as patients who do not take BZDs. Any potential benefits of increased treatment retention must be balanced against potential harmful effects of BZD use, such as drug overdose and addiction. Further studies must be performed to validate the results of treatment retention and to evaluate other factors that might affect OAT.
Resilience in the Classroom: A Qualitative Inquiry on How Parental Separation Affects College Students' Learning and Their Coping Abilities
Authors: Redulfin Genevieve , Tenebroso Desiree C. , Tagare Jr. Ruben L. , Siocon Ana Trisha F. , Gaspar Rishel Lyn P. , Adlaon Gauvin
Published: February 2025

Purpose of the study: This study aims to examine the impact of parental separation on the academic experiences of Bachelor of Physical Education students, focusing on how it influences their learning, engagement, and overall academic performance. By exploring both the challenges they face and the coping strategies they employ, the study seeks to provide a deeper understanding of the educational implications of parental separation and contribute to the development of targeted support systems for affected students.
Methodology:  A qualitative approach was used to gain an in-depth understanding of the participants' experiences. Interviews were conducted among 25 Bachelor of Physical Education students using a validated set of open-ended guide questions. The interviews were recorded, transcribed, and translated to ensure accuracy and consistency in data interpretation. For data analysis, thematic analysis was employed, allowing the researchers to identify recurring patterns, themes, and significant insights related to the effects of parental separation on students' learning and coping mechanisms. This systematic approach ensured that the findings were grounded in the participants' lived experiences, providing a comprehensive understanding of the phenomenon. 
Main Findings: The study identified five significant effects of parental separation on students: loss of focus, feeling depressed, missing classes, studying hard to reach goals, taking the situation positively, lack of financial support, delays in submitting schoolwork, reduced moral support from parents, and even dropping out of school. In terms of coping mechanisms, the participants identified five main strategies: engaging in physical activities, strengthening their faith in God, using the situation as motivation, surrounding themselves with supportive people, staying brave and keeping away from negativity, and remaining positive by going with the flow and being grateful. 
Novelty/Originality of this study: The study highlights the significant impact of parental separation on students’ academic performance and identifies physical activity as an effective coping mechanism. It provides valuable insights into the experiences and resilience strategies of Bachelor of Physical Education students, offering a culturally relevant perspective in the context of the Philippines.
Análise da aplicabilidade do treinamento funcional no treinamento físico militar do Exército Brasileiro: considerações metodológicas
Authors: Rodrigues Andrey Eduardo
Published: February 2025

Introdução: O treinamento funcional (TF) tem se destacado como uma abordagem moderna no condicionamento físico, beneficiando diversas populações, incluindo militares.
Objetivo: Examinar a literatura sobre o TF e analisar sua aplicabilidade como método para o treinamento físico militar (TFM) no Exército Brasileiro (EB).
Métodos: Estudo do tipo análise metodológica fundamentada na literatura científica exibida nas bases de dados Google Acadêmico, LILACS, SciELO, Scopus e PubMed, considerando estudos publicados entre 2005 e 2024, que abordassem o TF, TFM e sua aplicação no contexto militar.
Resultados e Discussão: O TF caracteriza-se por exercícios que aprimoram capacidades funcionais, como força, resistência, flexibilidade, coordenação e equilíbrio, por meio de movimentos multiarticulares e multiplanares. O TFM visa desenvolver a aptidão física necessária para atividades militares, seguindo princípios do treinamento físico. Métodos de TF, como o CrossFit, têm sido aplicados em forças armadas de outros países com resultados positivos. A integração do TF ao TFM pode melhorar o condicionamento físico geral e reduzir riscos de lesões. A utilização de sistemas de avaliação funcional, como a tela de avaliação de movimento funcional, o Functional Movement Screen (FMS), combinados com a aplicação do TF pode potencializar os benefícios, aprimorando o desempenho físico e operacional dos militares.
Conclusão: O TF, especialmente metodologias focadas em capacidades funcionais, mostrou-se adequado como método complementar ao TFM para o EB.
Mesterséges intelligencia és közbeszerzés
Authors: Tátrai Tünde
Published: February 2025

Cikkünk a mesterséges intelligencia alkalmazási lehetőségeiről szól a közbeszerzésben. Legfontosabb következtetése, hogy az MI alkalmazása megállíthatatlan, de az MI nem fogja helyettünk kialakítani a folyamatokat, létrehozni a pontos adatokat és nem fogja helyettesíteni a felkészült szakembereket sem.
Oroszország elleni szankciók a közbeszerzési eljárásokban és azok büntetőjogi vonatkozásai
Authors: Kozák-Demendi Ágnes
Published: February 2025

A cikk annak bemutatását tűzi ki célul, hogy hogyan is
áll jelenleg a közbeszerzési eljárásokban benyújtott iratok nyilvánosságának korlátozhatósága a legújabb
uniós bírói gyakorlat tükrében. A C-54/21. sz. Antea
Polska ügyben 2022 novemberében hozott ítélet összefoglalja az addigi esetjog lényeges elemeit, és több
tekintetben pontosítja azokat. A cikk konklúziója az,
hogy a Bíróság szerint minden esetben az ajánlatkérő
egyedi mérlegelésére van szükség a tekintetben, hogy a
dokumentum bizalmas kezelése indokolt-e, s ha igen
mennyiben. A Bíróság a lehető legteljesebb nyilvánosság koncepciójából indul ki, ami ugyanakkor jogos
indok alapján korlátozható. A bizalmas kezelést megalapozó indokok közül különösen jelentősek azok,
amelyek a titokgazda későbbi versenypozíciójának esetleges sérelmére vonatkoznak.
2023. júniusi összefoglaló
Authors: Nyerges Éva
Published: February 2025

A Közbeszerzési Hatóság állásfoglalások formájában ad
felvilágosítást a közbeszerzési eljárásokban résztvevő
jogalkalmazók számára a közbeszerzésekről szóló 2015.
évi CXLIII. törvény (a továbbiakban: Kbt.) és kapcsolódó végrehajtási rendeleteinek alkalmazásával összefüggő általános jellegű megkeresésekre.
Alábbiakban a Kbt. alkalmazásával összefüggő kérdésekre adott válaszainkat rendeztük sorrendbe, bízva
abban, hogy iránymutatásaink nem csak a kérdésfeltevőknek, hanem valamennyi Olvasónknak hasznos információkkal szolgálnak.
Felhívjuk Tisztelt Olvasóink figyelmét, hogy a közbeszerzésekre irányadó jogszabályok alkalmazásával
kapcsolatos döntések meghozatala mindenkor a közbeszerzési eljárások résztvevőinek joga és felelőssége.
Hangsúlyozzuk továbbá, hogy az állásfoglalásokban
megfogalmazott véleményeknek jogi ereje, kötelező
tartalma nincsen.
A közérdekű bejelentések vizsgálatának módszertana
Authors: Flek Lívia
Published: February 2025

Jelen cikk célja, hogy jogeseteken keresztül megismertesse az olvasókat a közérdekű bejelentések Közbeszerzési Hatóság (továbbiakban: Hatóság) által végzett kivizsgálásának folyamatával, az alkalmazott joggyakorlattal. A bemutatásra kerülő közérdekű bejelentéseket úgy válogattuk össze, hogy azok között a Hatóságnál leggyakrabban előforduló témák, a vizsgálatok során alkalmazott tipikus módszerek megjelenjenek. Évek óta nagy számban érkeznek közérdekű bejelentések a Hatósághoz, melyek kivizsgálása különösen fontos a közbeszerzések átláthatóbbá és eredményesebbé tétele, a kiszámítható joggyakorlat, a korrupció elleni küzdelem és a közbeszerzés rendszerének, a közbeszerzési jogszabályok mindenki számára érthetővé tétele érdekében.
Jogorvoslati aktualitások : A Döntőbizottság D.315/19/2024. számú határozata
Authors: Horváth Éva
Published: February 2025

A Közbeszerzési Értesítő Plusz jelen számában ismertetett jogesetek a jogszabályba ütközően visszavont ajánlattal, és a hamis adatszolgáltatás miatt korábban kizárt ajánlattevő ajánlatával kapcsolatosan az ajánlatkérő bírálati kötelezettségével foglalkoznak. A hatályos Kbt. alapján az ajánlatkérő jogosult a korábbi kizárás okainak súlyosságát mérlegelni, és akkor zárhatja ki a mérlegelést követően az ajánlatkérő az ajánlattevőt az adott közbeszerzési eljárásból, ha alapos oka van arra, hogy megkérdőjelezze annak megbízhatóságát. A jogorvoslati üggyel érintett tárgyak: A kérelmező részvételi jelentkezése jogellenesen visszavonásra került, mely tényt az ajánlatkérő a bírálatkor jogsértően nem vett figyelembe.
Gastrointestinal Tract Tumors with Microsatellite Instability: A Single-Center Experience
Authors: Беляк Наталья Петровна , Орлова Рашида Вахидовна , Раскин Григорий Александрович , Кутукова Светлана Игоревна , Андросова Александра Валерьевна , Смирнова Наталья Валерьевна , Варанкина Анна Алексеевна , Наталенко Софья Александровна
Published: February 2025

Введение. Развитие микросателлитной нестабильности в результате герминативной или спорадической мутации в генах системы репарации ошибочно спаренных нуклеотидов (MMR) является ключевым звеном в запуске механизмов канцерогенеза посредством формирования опухолевых неоантигенов, представляющих собой мишени для Т-лимфоцитов, что, в конечном счете, обусловливает высокую иммуногенность данных опухолей и их чувствительность к ингибиторам контрольных точек иммунитета.
Цель. Определение клинико-морфологических особенностей опухолей желудка, ободочной и прямой кишки с выявленной микросателлитной нестабильностью.
Материалы и методы. В ретроспективный анализ было включено 76 пациентов с установленным dMMR (36 пациентов больных колоректальным раком и 42 пациента со злокачественными новообразованиями желудка).
Результаты. Общими характеристиками для вышеописанных опухолей являются: местно-распространенный характер процесса (T3-T4, N2-N3), осложненное течение заболевания, превалирующее при иммуногистохимическом (ИГХ) тестировании выпадение белков РМS2, МLH1, прогрессирование и низкая частота достижения объективного ответа на фоне проводимой полихимиотерапией (ПХТ), высокая эффективность иммунотерапии (ИТ) в монорежиме или в комбинации с ПХТ (уровень контроля над заболеванием (65 % и 73,68 % для опухолей желудка и КРР соответственно)), медиана выживаемости без прогрессирования у пациентов, завершивших лечение ингибиторами контрольных точек, не достигнута как в группе рака желудка, так и в группе колоректального рака.
Experience of the Combined Treatment of Patients with Trigeminal Neuromas with Simultaneous Supra- and Subtentorial Spread
Authors: Безбородова Татьяна Юрьевна , Таняшин Сергей Владимирович , Золотова Светлана Вячеславовна , Струнина Юлия Владимировна
Published: February 2025

Введение. Невринома тройничного нерва (ТН) — опухоль с вариабельным естественным течением заболевания. При супра- и субтенториальном распространении данное новообразование вызывает трудности при выборе метода лечения в связи с рисками инвалидизации после хирургии или прогрессии после облучения.
Цель. Оценить результаты комбинированного лечения пациентов с невриномами тройничного нерва с одновременным супра- и субтенториальным ростом.
Материалы и методы. В материал исследования вошли данные о 23 пациентах с невриномами тройничного нерва с одновременным ростом опухоли в нескольких черепных ямках, которым было проведено комбинированное лечение в НМИЦ нейрохирургии им. ак. Н.Н. Бурденко с 2010 по 2022 г. На первом этапе всем пациентам была проведена операция по удалению опухоли, на втором — стереотаксически ориентированное лучевое лечение. Интервал между хирургией и облучением в среднем составил 14,1 мес.
Результаты. Проведенное комбинированное лечение способствовало улучшению мозжечковых нарушений (p-value = 0,008), исчезновению нистагма (p-value < 0,001), но также, в свою очередь, нарастанию недостаточности чувствительной порции тройничного нерва (p-value = 0,018), особенно гипестезии (p-value = 0,002), появлению нейропатической боли (p-value = 0,015) и парестезий в лице (p-value < 0,001), а также дисфункции двигательной порции тройничного нерва (p-value — 0,012).
При сравнении уровня активности по шкале Карновского до операции после хирургии и через 6 мес. после лучевого лечения наблюдалось снижение показателей непосредственно после удаления опухоли в 60 % случаев с последующим повышением уровня активности в отдаленном периоде в 65 % лечения (p-value < 0,001).
Медиана беспрогрессивной выживаемости в данной группе пациентов составила 106 мес. Трехлетняя беспрогрессивная выживаемость — 0,938.
Выводы. Нарастание дисфункции тройничного нерва после проведенного лечения вполне закономерно и обусловлено самой природой опухоли.  Улучшение уровня активности по шкале Карновского в отдаленном периоде (более 6 мес. после лучевого лечения) и высокий результат трехлетней беспрогрессивной выживаемости позволяют рассматривать комбинированное лечение как метод выбора в лечении пациентов с невриномами тройничного нерва с супра- и субтенториальным ростом.
Clinical Case: Perioperative Fluorescein ICG-Angiography of the Ureters in a Patient with an Orthotopic Neobladder after Repeated Ureteroileoanastomotic Strictures
Authors: Румянцева Дарья Игоревна , Мамижев Эльдар Мухамедович , Башмакова Яна Павловна , Носов Александр Константинович
Published: February 2025

Введение. Радикальная цистэктомия является одной из наиболее сложных операций в оперативной онкологии и урологии. Частота осложнений ортотопического мочевого резервуара колеблется на уровне 40-50 %, включая стриктуры уретероилеоанастомозов до 20 % случаев. Периоперационная флуоресценция тканей позволяет достоверно оценить степень их кровоснабжения. Нами был разработан и запатентован способ периоперационной визуализации мочеточников методом ICG-ангиографии.
Описание случая. Мужчина, 60 лет, после комплексного лечения мышечно-инвазивного рака мочевого пузыря в объёме трансуретральной резекции, неоадъювантной химиотерапии и радикальной цистэктомии с формированием ортотопического мочевого резервуара по Штудеру обратился по поводу нарушения самостоятельного мочеиспускания спустя 7 лет после основного лечения. При обследовании выявлены повторные стриктуры обоих уретероилеоанастомозов, наличие нефростомических дренажей. Выполнено оперативное вмешательство в объёме лапароскопической реимплантации обоих мочеточников к ортотопическому резервуару с использованием методики периоперационной флуоресцентной ICG-диагностики мочеточников. Операционный и послеоперационный период прошли без непосредственных осложнений. В настоящий момент пациент более трёх лет находится под динамическим наблюдением без признаков рецидива стриктур уретероилеоанастомозов.
Заключение. Периоперационная ICG-ангиография является эффективным и доступным методом диагностики и профилактики послеоперационных осложнений, ассоциированных с уретероилеоанастомозами.
Effect of Biosynthesized and commercial selenium nanoparticles on A 498 and CaCo-2 cancer cell lines
Authors: Selah Mohammad , Mohammad Ghada .A
Published: February 2025

Introduction. Cancer is a major cause of death worldwide, and there is a need for new treatment approaches. Nanoparticles have been proposed as a potential therapy for cancer due to their unique properties.
Aim. We conduct our study to assess the effect of selenium nanoparticles biosynthesized by Serratia marcescens and commercial selenium nanoparticles on the kidney cancer line (A-498) and the colon cancer line (CaCo-2) in comparison with the HdFn normal cell line.
Material and Methods. This study utilized two types of selenium nanoparticles (SeNPs) — one synthesized by the bacterium Serratia marcescens and the other commercially sourced from Nanoshel, USA — to assess the toxic effects on cancer cell lines. The kidney cancer (A-49.8) and colon cancer (CaCO-2) cell lines were cultured alongside a normal fibroblast control (Hdfn) using RPMI-1640 medium enriched with serum and antibiotics. The cytotoxicity of both types of SeNPs was evaluated using the MTT assay. After incubation, cell viability was measured by assessing absorbance at 570 nm, and the IC50 values were calculated to determine the concentration required for 50 % inhibition of cell growth.
Results. The results showed that the biosynthesized Selenium nanoparticles had a higher effect on the A-498 cancer line than on the normal line Hdfn. The highest lethal percentage of cancer cells for biosynthesized nanoparticles was 60.1 %, at a concentration of 400 μg/ml, while the lethal percentage for normal cells was 28.6 %. Commercial selenium nanoparticles showed a higher lethal percentage of 33.3 % for cancer cells and 28.1 % for normal cells at the same concentration. The results on colon CaCo-2 cancer cell line showed that commercial Selenium nanoparticles had a higher effect than biosynthesized ones: the lethal percentage of cancer cells with the concentration 400 μg/ml was 47.1 % vs 38.1 % respectively. Meanwhile, the lethal percentage at Hdfn was 28.1 % and 28.6 % with the same concentration, respectively. The IC50 at A-498 for biosynthesized and commercial SeNPs were 113.3 and 157.5 µg/ml respectively. The IC50 at CaCO2 for biosynthesized and commercial SeNPs were 121.6 and 102.8 µg/ml respectively. ID50 at Hdfn is 213.7 and 164.2 µg/ml respectively.
Safety of Use, Pharmacokinetics and Dosimetric Characteristics of the Radiopharmaceutical [99mTc]Tc- HYNIC-PSMA
Authors: Медведева Анна Александровна , Чернов Владимир Иванович , Зельчан Роман Владимирович , Рыбина Анастасия Николаевна , Брагина Ольга Дмитриевна , Зебзеева Ольга Сергеевна
Published: February 2025

Введение. В последние годы наблюдается значительный интерес к созданию радиофармацевтических лекарственных препаратов (РФЛП), меченых 99mTc, на основе низкомолекулярных ингибиторов ПСМА для визуализации опухолей предстательной железы.
Цель. Оценка безопасности применения, фармакокинетики и дозиметрических характеристик РФЛП [99мTс]Tc-HYNIC-ПСМА.
Материалы и методы. В исследование включено 10 больных раком предстательной железы (РПЖ) T1–4N0–3M0-1 стадий. Радиофармацевтический лекарственный препарат [99mTc]Tc-HYNIC-ПСМА вводился внутривенно болюсно в дозе 649,6 ± 70,7 МБк. Больные находились под динамическим наблюдением в течение 48 ч. после введения РФЛП с контролем лабораторных и клинических данных. Радионуклидное исследование проводилось на гамма-камере Symbia Intevo Bold (Siemens) в режиме Wholebody через 2, 4, 6 и 24 ч. после введения РФЛП, однофотонная эмиссионная компьютерная томография, совмещенная с КТ (ОФЭКТ/КТ) выполнялась через 2 ч. после введения индикатора. По данным постпроцессинговой обработки, анализировался уровень аккумуляции РФЛП в основных органах. Поглощенные дозы вычислялись программой OLINDA/EXM 1.1.
Результаты. Было показано, что [99mTc]Tc-HYNIC-ПСМА хорошо переносится пациентами, не было обнаружено патологически значимых изменений клинических лабораторных анализов. Период полувыведения РФЛП из плазмы крови составил 2,7 ч. Дозиметрические исследования показали, что основными критическими органами при использовании изучаемого РФЛП являются почки. Эффективная доза облучения пациентов при однократном внутривенном введении РФЛП составила 0,004 ± 0,0005 мЗв/МБк, а эквивалентная эффективная доза — 0,00748 ± 0,00014 мЗв/МБк. Показано, что ОФЭКТ/КТ с [99mTc]Tc-HYNIC-PSMA позволяет визуализировать ПСМА-позитивные опухоли предстательной железы, регионарные и отдаленные метастазы РПЖ.
Заключение. Полученные данные демонстрируют схожесть фармакокинетических параметров и дозовых нагрузок [99mTc]Tc-HYNIC-ПСМА с другими РФЛП на основе ПСМА-лигандов для ОФЭКТ-визуализации. Для оценки диагностической эффективности ОФЭКТ/КТ с [99mTc]Tc-HYNIC-ПСМА необходимо проведение дальнейших клинических исследований.
Consolidative Radiotherapy in the Treatment of Primary Mediastinal Large B-Cell Lymphoma
Authors: Крамынин Леонид Александрович , Филатова Лариса Валентиновна , Моталкина Маргарита Сергеевна , Зюзгин Илья Сергеевич , Никулина Юлия Александровна , Елхова Светлана Сергеевна , Ишматова Ирина Валерьевна , Зверькова Анна Андреевна , Волчёнков Станислав Андреевич , Добровольская Евгения Викторовна , Колупаев Никита Сергеевич , Колготина Анастасия  Геннадьевна , Елисеева Алина Олеговна , Семиглазова Татьяна Юрьевна
Published: February 2025

Введение. Первая линия терапии первичной медиастинальной крупноклеточной В-клеточной лимфомы является спорной и противоречивой. Наиболее неопределенным является вопрос назначения лучевой терапии после лекарственного этапа лечения. Согласно результатам нескольких ретроспективных исследований, от консолидирующей терапии можно отказаться у пациентов с полным метаболическим ответом и частичным метаболическим гистологически негативным ответом.
Цель. Сравнить отдаленные результаты лечения у пациентов с полным метаболическим ответом и частичным метаболическим ответом гистологически негативным после лекарственного этапа лечения в зависимости от проведения консолидирующей лучевой терапии.
Материалы и методы. Ретроспективно проанализированы отдаленные результаты лечения (выживаемость без прогрессирования и общая выживаемость) 63 пациентов, 31 пациент получил только 6 курсов химиотерапии по схеме DA-EPOCH-R и 32 пациента дополнительно получили консолидирующую лучевую терапию после лекарственного этапа лечения.
Результаты. Выживаемость без прогрессирования составила 93,6 % в группе наблюдения и 93,8 % в группе лучевой терапии, HR 0,55 (95 % ДИ 0,07-4,21). Общая выживаемость составила 96,8 % в группе наблюдения и 96,9 % в группе лучевой терапии, HR 0,98 (95 % ДИ 0,06-15,74).
Выводы. Проведенное исследование демонстрирует отсутствие положительного влияния лучевой терапии на отдаленные результаты лечения у пациентов с полным метаболическим ответом и частичным метаболическим гистологически негативным ответом после иммунохимиотерапии и позволяет отказаться от консолидирующей лучевой терапии без потери эффективности лечения.
Evaluating mobile-based data collection for crowdsourcing behavioral research
Authors: Esch Dennis T. , Mylonopoulos Nikolaos , Theoharakis Vasilis
Published: February 2025

Online crowdsourcing platforms such as MTurk and Prolific have revolutionized how researchers recruit human participants. However, since these platforms primarily recruit computer-based respondents, they risk not reaching respondents who may have exclusive access or spend more time on mobile devices that are more widely available. Additionally, there have been concerns that respondents who heavily utilize such platforms with the incentive to earn an income provide lower-quality responses. Therefore, we conducted two studies by collecting data from the popular MTurk and Prolific platforms, Pollfish, a self-proclaimed mobile-first crowdsourcing platform, and the Qualtrics audience panel. By distributing the same study across these platforms, we examine data quality and factors that may affect it. In contrast to MTurk and Prolific, most Pollfish and Qualtrics respondents were mobile-based. Using an attentiveness composite score we constructed, we find mobile-based responses comparable with computer-based responses, demonstrating that mobile devices are suitable for crowdsourcing behavioral research. However, platforms differ significantly in attentiveness, which is also affected by factors such as the respondents’ incentive for completing the survey, their activity before engaging, environmental distractions, and having recently completed a similar study. Further, we find that a stronger system 1 thinking is associated with lower levels of attentiveness and acts as a mediator between some of the factors explored, including the device used and attentiveness. In addition, we raise a concern that most MTurk users can pass frequently used attention checks but fail less utilized measures, such as the infrequency scale.
CADEIA DE MARKOV PARA MODELAGEM DE OCORRÊNCIA CONSECUTIVA DE DIAS SECOS E CHUVOSOS
Authors: Santos Roziane Sobreira dos , Oliveira Robson Alves de , Evangelista Dilson Henrique Ramos
Published: February 2025

Objetivo: Modelar a ocorrência diária de precipitação em Ji-Paraná, Rondônia, utilizando uma Cadeia de Markov discreta de dois estados, visando estimar a matriz de probabilidade de transição entre dias secos e chuvosos por mês, e compreender padrões sazonais para auxiliar na gestão de recursos hídricos e na tomada de decisões. Métodos: Foi utilizado Cadeia de Markov de dois estados, considerando como seco o dia com precipitação inferior a 1 mm. A matriz de transição de primeira ordem foi calculada para avaliar as probabilidades de transição entre dias secos e chuvosos consecutivos em cada mês. Assumiu-se que a ocorrência de um dia seco ou chuvoso depende unicamente das condições do dia anterior. Resultados: Os meses de dezembro a março concentram cerca de 59% do total precipitado. A probabilidade de ocorrência de dias secos nesses meses é geralmente menor que 0,25. Durante os meses de junho a agosto, a probabilidade de um dia seco ser precedido por outro dia seco supera 0,9. Nos meses de abril, outubro e novembro, há uma alta probabilidade de ocorrência de dois dias chuvosos consecutivos. Conclusão: O modelo de Cadeia de Markov foi eficaz em capturar o padrão sazonal de dias chuvosos e secos em Ji-Paraná, Rondônia, demonstrando utilidade como ferramenta para análise e previsão de padrões de precipitação na região.
Avaliação temporal do descarte irregular de resíduos sólidos em um bairro no município de Pelotas/RS
Authors: Pitana Kamilla da Silva Martins , Suzuki Luis Eduardo Akiyoshi Sanches
Published: February 2025

A qualidade de vida é um parâmetro importante para o desenvolvimento humano, logo, o saneamento básico é um dos principais parâmetros desse processo. Com quatro pilares, o saneamento básico é formado por abastecimento de água, esgotamento sanitário, drenagem urbana e coleta de resíduos, sendo este último um pilar importante no cotidiano, além de influenciar indiretamente em saúde pública. O objetivo do presente estudo foi realizar uma avaliação temporal do descarte irregular de resíduos sólidos em um bairro no município de Pelotas, Estado do Rio Grande do Sul. O estudo foi desenvolvido no período de 2018 a 2024, através de visitas “in loco” e registro fotográfico de locais de descarte irregular de resíduos. Levantou-se possíveis causas que podem levar ao descarte irregular nos locais e os possíveis impactos. Sugere-se a revitalização de algumas áreas de descarte irregular, a ampliação da coleta conteinerizada para o bairro, e intensificar a orientação e conscientização das pessoas sobre os impactos econômicos, ambientais e de saúde a partir do descarte irregular.
Atividades de Pilates inovando a aprendizagem e o desenvolvimento infantil na escola
Authors: Yavorski Rosely
Published: February 2025

Nos últimos anos observou-se que houve um retrocesso na educação geral. Para equilibrar esta situação pesquisadores e profissionais da educação buscam novas formas de inovar e melhorar a educação por meio de tecnologias. No entanto, técnicas corporais quando utilizadas multidisciplinarmente além de melhorar a postura e motricidade do aluno, também desenvolvem aspectos cognitivos importantes para a aprendizagem. O objetivo da investigação foi o de demonstrar que exercícios simples do método Pilates otimizam o desenvolvimento global do aluno da educação infantil. A metodologia aplicada desenvolveu-se com base na pesquisa ação, onde alunos da educação infantil de escolas municipais do município de Sarandi-PR-Brasil foram avaliados em seu desenvolvimento motor e escolar por provas já validadas na literatura científica. Como resultado espera-se que os alunos melhorem a concentração, postura, memoria, integração, e a aprendizagem. Concluiu-se que após atividades do método Pilates integradas com disciplinas como: ciências, português, matemática, os alunos demostraram maior interesse pela aprendizagem e a capacidade de concentrar-se em atividades anteriormente desmotivantes.
INTERSECÇÕES E SAÚDE: COMO O GÊNERO, A SEXUALIDADE E A RAÇA ATRAVESSAM A ATUAÇÃO NO CONSULTÓRIO NA RUA
Authors: Berto Clara da Silva , Oliveira Hyago Gabriel Faria de , Moura Bruna Bertasso Teixeira de , Souza Ricardo Henrique Bitencourt de , Tokuda André Masao Peres , Radin Luciana , Gomes Jamila de Lima , Queiroz Bruna Fernanda Barbosa , Lima Andréia Maria de , Portugal Heloísa Helena de Almeida
Published: February 2025

Introdução: O Consultório na Rua é uma política pública de saúde com o objetivo de promover assistência em saúde à População em Situação de Rua, para que esse atendimento seja de maneira integral faz-se necessário entender a lógica de intersecções, em como o gênero, a sexualidade e raça influenciam nas demandas dos grupos atendidos e como isso influencia a forma de atuação das equipes que prestam o cuidado. Objetivo: Discutir o quanto o atendimento do Consultório na Rua é atravessado pelos marcadores sociais de raça, gênero e classe social. Método: Utilizou-se a revissão narrativa, com busca avançada feita nas bases de dados LILACS, BVS E SCIELO. Resultados: A partir da pesquisa feita nas bases de dados, seis artigos foram selecionados pelos critérios de inclusão e divididos em três categorias para facilitar a discussão: Dificuldades e empecilhos para o consultório na rua; Manejo especial dos pacientes em situação de rua durante o atendimento e como a situação de vulnerabilidade pode dificultar o atendimento. Conclusões: O estudo destaca a necessidade de uma abordagem integrada para enfrentar as múltiplas formas de discriminação, reconhecendo sua interseccionalidade e impacto mútuo. Identificou-se que o programa Consultório na Rua enfrenta desafios significativos, desde limitações fiscais e lacunas na formação profissional até a exigência de uma ação intersetorial coordenada para garantir um atendimento integral e qualificado à população em situação de rua.
ESTRATÉGIAS DE COMUNICAÇÃO ALTERNATIVA E AMPLIADA (CAA) NA EDUCAÇÃO DE ALUNOS COM TEA: UM DESAFIO PARA FORMAÇÃO DE PROFESSORES
Authors: Bezerra Thaynara de Moura , Vianna Pedro Henrique Farias , Costa Sheila Sousa da , Teixeira Haciane Moreira da Silva , Freitas Ana Paula da Costa , Santos Sirlei Alves dos , Santos Hiarles Dias dos , Faria Rose Cristina Veiga de , Correia Sunami Graças de Farias , Martins Márcia Thallita Nunes
Published: February 2025

A educação inclusiva enfrenta desafios significativos ao atender alunos com Transtorno do Espectro Autista (TEA), especialmente no que se refere à comunicação. Nesse contexto, a Comunicação Alternativa e Ampliada (CAA) surge como um conjunto de estratégias que facilita a interação e o aprendizado desses estudantes. No entanto, a implementação eficaz da CAA depende da formação adequada dos professores, o que ainda representa um obstáculo na prática educacional. Diante disso, este estudo tem como objetivo analisar as estratégias de CAA aplicadas à educação de alunos com TEA e os desafios enfrentados na formação docente para sua utilização. Metodologicamente, trata-se de uma revisão de literatura, baseada na análise de 16 artigos científicos publicados nos últimos dez anos em língua portuguesa, obtidos no Google Acadêmico. A análise dos estudos revelou que, apesar dos benefícios comprovados da CAA, há uma carência na preparação dos professores para sua implementação, o que impacta diretamente a inclusão dos alunos autistas. Além disso, a formação docente ainda carece de abordagens que integrem efetivamente essas estratégias às práticas pedagógicas. Conclui-se que a adoção da CAA na educação de alunos com TEA requer investimentos na capacitação de professores e na disseminação de metodologias acessíveis. O estudo contribui para a ampliação do debate acadêmico e aponta para a necessidade de pesquisas futuras que avaliem empiricamente a eficácia dessas estratégias na prática escolar.
USO DE DIFERENTES MATERIAIS PARA TRATAMENTO DE ÁGUAS DE POÇOS DE PETRÓLEO: TRATAMENTO DE ÁGUAS PRODUZIDAS CONTAMINADAS
Authors: Silva Ítalo Felipe DA , Oliveira Ana Karla Costa de
Published: February 2025

O trabalho tem como objetivo tratar amostra industrial real com três adsorventes materiais e avaliar as respostas desse tratamento. Para essa realização caracterizou-se a água bruta, bem como a tratada. Em seguida, aplicaram-se os processos adsortivos com diferentes materiais (casca de coco, carvão ativo e areia de praia); Na etapa seguinte, relacionaram-se as análises de Teor de Óleos e Graxas e Turbidez e calcularam –se as eficiências de remoção em porcentagem. De acordo com os valores obtidos observou-se que o maior percentual de remoção (96,34%) do óleo ocorreu com o uso de 120g do adsorvente areia de praia, dentro da faixa estudada, provavelmente devido ao aspecto estrutural poroso que apresenta o adsorvente, característico de rochas que armazenam petróleo. Assim, o adsorvente captura melhor o poluente. Os resultados foram bastante satisfatórios dentro da faixa estudada.
GREEN AREA AND VEGETATION COVER INDEXES OF THE SQUARES IN THE MUNICIPALITY OF ITABERAÍ, GO
Authors: Silva Ricardo Carvalho , Peixoto Josana de Castro
Published: February 2025

The interest in analyzing green spaces in urban areas and correlating them with human health has expanded due to rapid urbanization, increased pollution, and growing trends of physical inactivity among the population. Considering the importance of preserving natural areas for promoting public health, the present study aimed to evaluate green spaces (green areas, vegetation cover, and vegetation cover percentage) in the Municipality of Itaberaí, Goiás. For this purpose, with the assistance of Geographic Information Systems (GIS) technology, the Green Area Index (GAI), the Vegetation Coverage Index (VCI), and the Vegetation Coverage Percentage (VCP) of the studied urban area were calculated. In the analysis of the IAV, the base map from Google Satellite in the QGIS 3.28.10 software was used; however, the ICV was measured using the Normalized Difference Vegetation Index (NDVI), calculated from images downloaded from the CBERS-4A satellite. With the application of the methodology in question, Itaberaí demonstrated that only 13.80% of its urban territory is covered by vegetation. Regarding the IAV, the study obtained a value of 1.32 m2/inhabitant, classified as very poor by the Brazilian Society of Urban Arborization (SBAU). Given the above, it is concluded that the urban area of Itaberaí requires special attention regarding the analyzed topic, as the city does not meet the internationally recommended levels of interurban vegetation.
RENEWABLE ENERGY SOURCES: AN OVERVIEW OF CLEAN ALTERNATIVES
Authors: Ribeiro Lucas Figueiredo , Silva Sandro Dutra e
Published: February 2025

A STUDY WAS CARRIED OUT ON RENEWABLE ENERGY SOURCES IN A GLOBAL CONTEXT. THE INVESTIGATION BEGAN BY ADDRESSING THE ISSUE OF THE ABUNDANCE OF THESE RESOURCES AROUND THE WORLD, HIGHLIGHTING THEIR INTRINSIC IMPORTANCE IN THE TRANSITION FROM AN ENERGY MATRIX DEPENDENT ON FOSSIL FUELS TO A MORE SUSTAINABLE AND ENVIRONMENTALLY FRIENDLY ONE. IT THEN EXAMINED IN DETAIL THE EVOLUTION AND REMARKABLE ADVANCES THAT THESE ENERGY SOURCES HAVE EXPERIENCED IN RECENT YEARS. TO ILLUSTRATE THIS EVOLUTION, A GRAPH WAS PRESENTED THAT CLEARLY AND OBJECTIVELY DEMONSTRATES THE STEADY GROWTH OF RENEWABLE ENERGIES OVER THE LAST FIVE YEARS, SIGNALING SIGNIFICANT PROGRESS TOWARDS A GREENER AND MORE RESILIENT ENERGY MATRIX.FINALLY, THE CLASSIFICATION OF THE MAIN RENEWABLE ENERGY SOURCES, INCLUDING SOLAR, WIND, GEOTHERMAL, OCEAN, BIOENERGY AND HYDROELECTRIC, WAS EXPLORED, HIGHLIGHTING THE INDIVIDUAL ROLES THEY PLAY IN REDUCING GREENHOUSE GAS EMISSIONS AND DRIVING THE SEARCH FOR CLEANER AND MORE SUSTAINABLE ENERGY SOLUTIONS FOR THE FUTURE. AS A RESULT, THIS WORK OFFERS A COMPREHENSIVE AND UP-TO-DATE OVERVIEW OF THE STATE OF RENEWABLE ENERGY SOURCES IN THE GLOBAL CONTEXT, HIGHLIGHTING THEIR GROWING IMPORTANCE IN A WORLD INCREASINGLY AWARE OF ENVIRONMENTAL ISSUES AND EVOLVING ENERGY NEEDS.
PREVALENCE OF DEPRESSIVE SYMPTOMS IN INSTITUTIONALIZED ELDERLY IN A MUNICIPALITY IN THE INTERIOR OF THE STATE OF GOIÁS
Authors: Arantes Ana Paula Felix , Pires Fabiana Machado , Neto Abí­lio José de Oliveira , Santos Maria Eduarda Ribeiro dos , Silva Renato Canevari Dutra da , Oliveira Deise Aparecida de Almeida Pires
Published: February 2025

The presence of depressive symptoms in the elderly, especially those residing in long-term care facilities (LTCFs), allows for an understanding of how the institutionalized environment, marked by physical inactivity, functional decline, loss of personal autonomy, and reflection on one's own death, can affect the mood and life and future perspective of these individuals. This study aims to investigate the prevalence of depressive symptoms in institutionalized elderly individuals in a municipality in the interior of the state of Goiás. This cross-sectional study was conducted in the only ILPI in the municipality of Rio Verde – GO. The study population consisted of the 100 elderly residents of the ILPI during the data collection period, and those over 60 years of age and with more than six months of institutionalization were included in the study, while those with a medical diagnosis of mental disorder recorded in their records were excluded. Sociodemographic, economic, general health, institutionalization, functional dependency (Functional Independence Measure), and depressive symptom assessment (15-item Geriatric Depression Scale) information were collected. It was observed that (n=9; 30.3%) of the evaluated elderly presented depressive symptoms, reflecting the need for significant attention to the mental well-being of this vulnerable population, such as early identification and appropriate treatment of these symptoms.
COMPARISON OF THE ACCURACY OF PERIAPICAL RADIOGRAPHY AND CONE-BEAM COMPUTED TOMOGRAPHY IN THE DIAGNOSIS OF INFLAMMATORY ROOT RESORPTION
Authors: Loures Lara Lopes Amaral , Freitas Neurinelma da Silva Santos , Oliveira Helder Fernandes de , Serpa Giulliano Caixeta , Guedes Orlando Aguirre
Published: February 2025

The objective of this study was to compare the accuracy of periapical radiography (Rx-P) and cone beam computed tomography (CBCT) in detecting inflammatory root resorption. Fourteen patients referred to the Emergency Service were evaluated (8 female; 57.14% and 6 male; 42.86) aged between 18 to 64 years. The sample consisting of 52 teeth was divided according to their dental group, with 6 being anterior, 23 premolars, and 23 molars. The number of roots analyzed was 88. Regarding the diagnosis, the classifications were as follows: periapical abscess without fistula phase I (n = 1; 1.92%), pulpal necrosis (n = 1; 1.92%), asymptomatic apical periodontitis (n = 36; 69.23%), symptomatic apical periodontitis (n = 14; 26.92%). Regarding the type of infection, 42 (80.77%) teeth presented with primary infection and 10 teeth (19.23%) with secondary infection. High prevalence was observed after the use of tomography. However, there was no statistically significant difference between Rx-P and TCFC. Advances in clinical evaluation have greatly improved diagnostic accuracy. CBCT allows for a greater likelihood of correct management of resorption lesions compared to intraoral radiographs.