bluuebunny/crossref_metadata_2025 huggingface dataset:
A Leitura como Ação Formadora do Desenvolvimento Pessoal e Profissional do Indivíduo / Reading as an Action for the Formation of the Individual's Personal and Professional Development
Authors: Carvalho Ricardo Gondim de , França Aurenia Pereira de
Published: January 2022

Resumo: Este artigo trata-se de uma pesquisa de caráter bibliográfico com o objetivo de analisar a importância da leitura para o desenvolvimento pessoal e profissional do indivíduo, bem como, descrever o conceito de leitura, apresentar a participação das instituições no fomento à leitura, e compreender a importância da leitura na construção do indivíduo. Apresenta a seguinte problemática: Qual a importância da leitura na construção pessoal e profissional do indivíduo? Para embasar a discussão foram consultados sites, artigos, dissertações e autores que discorrem sobre a temática em foco, entre eles destacam-se: Burke (2003), Silva (1991), Martins (1994), Freire (1989), Chartier (1990), Solé (1998), Weiers (2011). Com esse estudo espera-se ter êxito na análise da importância da leitura para o desenvolvimento do indivíduo pessoal e profissional. Com o intuito de aprender a ler e de ler para aprender considerando a capacidade de compreender e interpretar textos escritos como um instrumento necessário para atingir um desenvolvimento pleno, no contexto de uma sociedade letrada. Palavras-Chave: Leitura. Educação. Ensino-Aprendizagem.  Abstract: This article is a bibliographic research with the objective of analyzing the importance of reading for the personal and professional development of the individual, as well as describing the concept of reading, presenting the participation of institutions in promoting reading, and understanding the importance of reading in the construction of the individual. It presents the following issue: What is the importance of reading in the individual's personal and professional construction? To support the discussion, websites, articles, dissertations and authors who discuss the topic in focus were consulted, including: Burke (2003), Silva (1991), Martins (1994), Freire (1989), Chartier (1990 ), Solé (1998), Weiers (2011). This study is expected to be successful in analyzing the importance of reading for the development of the personal and professional individual. In order to learn to read and to read to learn, consider the ability to understand and interpret written texts as a necessary instrument to achieve full development, in the context of a literate society. Keywords: Reading. Education. Teaching-Learning.
A Importância do Farmacêutico no Acompanhamento Farmacoterapêutico em Pacientes Idosos Polimedicados / The Importance of the Pharmacist in the Pharmacotherapeutic Follow-Up in Polymedicate Elderly Patients
Authors: Arruda Ariele Oliveira , Silva Luciene Rodrigues da , Malheiro Luciano Hasimoto
Published: January 2022

Resumo: A atuação do profissional farmacêutico se tornou indispensável no cuidado com a saúde do idoso. principalmente na educação de um consumo de medicamentos consciente e seguro. Em decorrência do envelhecimento, o indivíduo se torna mais propenso a evoluções patológicas, e assim aumentando o consumo de medicamentos. Isso amplia as possibilidades de erros relacionados aos fármacos, como interações, reações adversas e incidentes relacionados a administração medicamentosa. Desta forma, o presente trabalho teve como objetivo realizar uma revisão integrativa sobre a importância do acompanhamento farmacêutico na promoção da qualidade de vida dos idosos polimedicados e detectar prováveis riscos relacionados ao uso de medicamentos. A metodologia empregada consiste em um estudo de pesquisa bibliográfica com abordagem integrativa. A busca pelas publicações foi realizada através das plataformas Biblioteca Virtual em Saúde (BVS), Pubmed, Google Acadêmico e Periódico CAPES. A literatura disponível indica que o farmacêutico possui papel fundamental na orientação medicamentosa do idoso polimedicado, garantindo um tratamento farmacoterapêutico mais eficaz e seguro, e assim proporcionando maior qualidade de vida durante o processo de envelhecimento.Palavras-chave: Automedicação; Polifarmácia; Uso Inadequado de medicamentos. Abstract: The role of the pharmacist has become essential in caring for the health of the elderly. mainly in the education of a conscious and safe consumption of medicines. As a result of aging, the individual becomes more prone to pathological developments, thus increasing the consumption of medications. This expands the possibilities of drug-related errors, such as interactions, adverse reactions and incidents related to drug administration. Thus, this study aimed to carry out an integrative review on the importance of pharmaceutical monitoring in promoting the quality of life of polymedicated elderly people and detecting probable risks related to the use of medication. The methodology used consists of a bibliographic research study with an integrative approach. The search for publications was performed using Biblioteca Virtual em Saúde (BVS), Pubmed, Google Scholar and Periódico CAPES. The available literature indicates that the pharmacist has a fundamental role in the medication guidance of the polymedicated elderly, ensuring a more effective and safer pharmacotherapeutic treatment, and thus providing a better quality of life during the aging process.Keywords: Inappropriate use of medications. Polypharmacy. Self-medication.
Ansiedade e Depressão em Universitários a Área da Saúde: Uma Revisão Integrativa / Anxiety and Depression in University Students in the Health Area: An Integrative Review
Authors: Dias Luana Gonçalves , Silva Nubia Alves da , Oliveira Saphira Sampaio Barbosa de , Marques Matheus Santos
Published: January 2022

O presente trabalho concerne em uma revisão integrativa de literatura, de caráter qualitativo e quantitativo, que culminou em resultados que demonstra as causas e o predomínio de ansiedade e depressão em universitários dos cursos da área da saúde. Realizou- se uma busca dos artigos na base de dados: Scientific Electronic Library Online (SCIELO), e google scholar, disponíveis no idioma português no período de 2016 a 2021. O resultado da pesquisa bibliográfica, após aplicar rigorosamente os fundamentos de inclusão e exclusão, foi a seleção de 9 artigos. A bibliografia demonstrou que acadêmicos tendem a ter até 20% mais viabilidade de desenvolver o dado problema se comparado a população geral. O aumento de demandas, associados à pressão, estresse, saída da residência dos familiares, são fatores que colabora para essa problemática. A psicologia alinhada com terapia pode suavizar a pressão para que a vivência na universidade não seja negativa, pois, por meio do autognosia (conhecimento de si próprio), o aluno distende habilidades que podem amparar no manuseio dos seus próprios conflitos.---The present study concerns an integrative literature review, qualitative and quantitative, which culminated in results that demonstrate as causes and the predominance of anxiety and depression in university students in health care courses. The following articles were searched in the database: Scientific Electronic Library Online (SCIELO), and academic google, available in Portuguese from 2016 to 2021. The result of the bibliographic search, after rigorously applying the inclusion and exclusion fundamentals, was the selection of 9 articles. The bibliography indexes that academics tend to have up to 20% more feasibility of developing the given problem compared to the general population. The increase in demands, associated with pressure and stress when family members leave their homes, are factors that contribute to this problem. Psychology aligned with therapy can alleviate the pressure so that the university experience is not negative, because, through self-knowledge (knowledge of oneself), the student has skills that can support the handling of their own conflicts.
Encontros na Península, de Milton Hatoum: Um diálogo com A causa secreta, de Machado de Assis / Encontros na Península, by Milton Hatoum: A dialogue with the Secret Cause, by Machado de Assis
Authors: Ataíde Maria Betânia Da Costa , Amorim José Edilson De
Published: January 2022

Resumo: Nesse artigo temos como objetivo apresentar uma leitura comparada do conto “Encontros na Península”, de Milton Hatoum com “A causa secreta”, de Machado de Assis. Ao longo do trabalho apresentamos algumas reflexões em torno da pergunta da personagem Victoria Soller. Teoricamente nos baseamos em Carvalhal (2004) com a obra Literatura Comparada, e em Bakhtin Dialogismo e Polifonia (2016). Notamos através das relações intertextuais que o conto “Encontros na Península” dialoga com alguns textos machadianos. Palavras-chave: Machado de Assis; Milton Hatoum; Literatura comparada. Abstract: In this article we aim to present a comparative reading of the short story “Encontros na Península”, by Milton Hatoum with “A causa secreta”, by Machado de Assis. Throughout the work, we present some reflections on the question of the character Victoria Soller. Theoretically, we are based on Carvalhal (2004) with the book Comparative Literature, and on Bakhtin Dialogismo e Polifonia (2016). Through the intertextual relationships, we noticed that the short story “Encontros na Península” dialogues with some Machadian texts. Keywords: Machado de Assis; Milton Hatoum; Comparative literature.
Inclusão do Aluno Autista na Escola: Um Olhar sobre a Mediação Pedagógica / Inclusion of the Autistic Student in School: A Look at Pedagogical Mediation
Authors: Araújo Iracelia Pereira Silva de , Menezes Aurelania Maria De Carvalho
Published: January 2022

Resumo: Esse trabalho teve por objetivo apresentar uma abordagem geral dos pacientes autistas bem como, as características e dificuldades que são enfrentadas para a inclusão destes, no âmbito escolar. Para fundamentação da pesquisa, foram realizadas buscas nas bases de dados, usando as palavras-chaves: autismo, inclusão escolar, educação básica. Também foram realizadas leituras de aportes teóricos que ampliam e enriquecem a discussão da temática. A busca se deu através de artigos indexados nas plataformas de dados (Google acadêmico) e Biblioteca Virtual De Saúde (BVS) e SCIELO. Foi constatado que ainda existe uma larga escala de pessoas na sociedade, que precisam ter mais conhecimento acerca da síndrome para que desse modo, saibam lidar e possam entender o paciente autista, porque compreendendo é mais fácil a inclusão destes no meio social e escolar. Entender o comportamento de cada autista também favorece a melhor forma para desenvolvimentos de estratégias de ensinos que visem estimular a aprendizagem e o comportamento destes. Palavras-Chave: Autismo; Inclusão Escolar; Atenção Básica. --- Inclusion of the Autistic Student in School: A Look at Pedagogical Mediation Abstract: This work aimed to present a general approach to autistic patients as well as the characteristics and difficulties that are faced for their inclusion in the school environment. To support the research, searches were carried out in the databases, using the keywords: autism, school inclusion, basic education. There were also readings of theoretical contributions that broaden and enrich the discussion of the subject. The search was carried out through articles indexed in data platforms (academic Google) and Virtual Health Library (BVS) and SCIELO. It was found that there is still a large scale of people in society, who need to have more knowledge about the syndrome so that, in this way, they know how to deal with and can understand the autistic patient, because understanding their inclusion in the social and school environment is easier. Understanding the behavior of each autistic person also favors the best way to develop teaching strategies aimed at stimulating their learning and behavior. Keywords: Autism; School inclusion; Primary Care.
Educação e sua Importância no Processo de Inclusão de Crianças com TDAH: Inquietações a serem enfrentadas no Ensino Regular / Children with ADHD: Concerns to be Faced in Regular Education
Authors: Moura Eliane Da Silva Ferreira , Bezerra Fabiana Correia
Published: January 2022

Resumo: O intuito da pesquisa foi conhecer a importância da educação de acordo com o processo de inclusão, o que afirmam os pesquisadores acerca do Transtorno de Déficit de Atenção e Hiperatividade (TDAH). Quanto ao processo metodológico, foi realizada pesquisa bibliográfica com abordagem qualitativa e estudo de caso com entrevista semiestruturada. Os efeitos apontaram as dificuldades de adaptação por conta da falta de qualificação específica dos professores no ensino regular, falta de conhecimento por parte das famílias, dificuldades de aprendizagens e deficiência quanto à equidade no ensino. Concluiu-se que a educação inclusiva ainda está se moldando e se adaptando, seja na sociedade ou nas políticas públicas. Ao mesmo tempo em que parte da dificuldade de aprendizagem desses alunos com necessidades especiais, é dos pais sem informação adequada e os profissionais da educação, como também a sociedade e a comunidades escolares sem nenhuma formação ou informações adequadas. Palavras-chave: Ensino-aprendizagem. Inclusão. Transtorno de Déficit de Atenção e Hiperatividade. Capacitação.   __________________________ Abstract: The purpose of the research was to know the importance of education according to the inclusion process, which researchers claim about Attention Deficit Hyperactivity Disorder (ADHD). As for the methodological process, a bibliographical research was carried out with a qualitative approach and a case study with semi-structured interview. The effects pointed out the difficulties of adaptation due to the lack of specific qualification of teachers in regular education, lack of knowledge on the part of families, learning difficulties and deficiencies in terms of equity in education. It was concluded that inclusive education is still shaping and adapting, whether in society or in public policies. While part of the learning difficulty of these students with special needs is parents without adequate information and education professionals, as well as society and school communities without any training or adequate information. Keywords: Teaching-learning. Inclusion. Attention Deficit Hyperactivity Disorder. Training.
liberdade na era digital
Authors: Souza Adeline Cerqueira , Costa Danielle Sobral Porto
Published: January 2022

O presente texto pretende refletir sobre a Educação de Jovens e Adultos no contexto da liberdade segundo alguns filósofos e pensadores contemporâneos. Inicialmente foi feita uma análise expondo alguns conceitos acerca da liberdade na visão de diferentes autores, a exemplo de: Sartre, Kant, Marx, Guy Debord (2003), Hannah Arendt (1983) e Paulo Freire (1979; 1981; 1986; 1997). Em seguida, versa-se que, no mundo contemporâneo, a internet é a força que mais tem revolucionado os meios de comunicação, trazendo benefícios diversos num âmbito geral, como também o aumento considerável de possibilidades de desvirtuação do seu uso. Dessa forma, procurou-se fundamentar a partir de leis que normatizam esse uso e que garantam liberdade e privacidade ao indivíduo. Num terceiro momento, discutiu-se a efetivação do direito à educação dos jovens e adultos privados de liberdade, incluindo esses educandos na era digital, valorizando-os diante da sociedade e do mundo do trabalho, permitindo a inclusão educacional e social.
Paulo Freire ou o poder da palavra
Authors: Silva Carla Beatriz Rodrigues
Published: January 2022

Resenha da obra "Educação como prática de libertadade", de Paulo Freire. O livro é um convite para a era dos discursos e dos manifestos sobre a educação.
Auto-organização
Authors: Jadejiski Rainei Rodrigues , Oliveira Eric de , Lima Alessandra Ribeiro
Published: January 2022

Este texto relata a experiência de uma pesquisa desenvolvida no ano de 2015 no Assentamento Boa Esperança, localizado no município de Alto Rio Novo/ES. O estudo objetivou compreender como se dá a produção de conhecimentos na auto-organização que se estabelece como processo educativo mediante saberes e fazeres que atravessam o cotidiano das famílias campesinas. Por meio de uma pesquisa qualitativa com abordagem dialética, três unidades familiares foram investigadas e, a partir da análise dos dados coletados, constatou-se que os processos de auto-organização influenciam nos modos como cada família produz a sua sobrevivência e contribuem para uma formação humanística dos sujeitos envolvidos. As vozes dos sujeitos pesquisados evidenciaram que a auto-organização representa uma possibilidade de educação não escolar, pois ela favorece a produção e a propagação de saberes vivenciados na prática.
propriedades do butiá benéficas à saúde a partir da visão dos integrantes-chave da Rota dos Butiazais
Authors: Portelinha Márcia Kaster , Barbieri Rosa Lía , Ceolin Teila
Published: January 2022

O estudo teve o objetivo descrever o conhecimento dos integrantes da Rota dos Butiazais a respeito das propriedades do butiá que são benéficas à saúde. Pesquisa qualitativa, de abordagem descritiva, com a coleta de dados em março e abril de 2020. Foram aplicadas entrevistas semiestruturadas a 20 integrantes-chave da Rota dos Butiazais. As entrevistas foram aplicadas de forma presencial a 9 pessoas (gravadas e transcritas pela pesquisadora) e via e-mail para 11 participantes (por motivo do distanciamento social, imposto pela pandemia do Covid-19). Foram utilizados: análise de conteúdo temática, de Laurence Bardin, e referencial teórico da Teoria das Representações Sociais de Serge Moscovici. Os participantes relataram sobre os compostos antioxidantes, fibras, carotenos, vitaminas e potássio presentes na polpa de butiá, expondo que estes compostos são benéficos para a saúde. Também trouxeram que o butiá tem valor nutritivo, é rico em vitamina C, e que podem existir propriedades que não tenham sido estudadas. Cada entrevistado tem uma história pessoal e familiar distinta, mas convergem em vários pontos relacionados ao conhecimento das propriedades do butiá benéficas à saúde. Os relatos dos participantes demonstram as representações sociais alicerçadas a partir do butiá.
avaliação escolar no Ensino Secundário em Moçambique e os indícios de uma educação excludente
Authors: Culimua Aristides Silvestre
Published: January 2022

Este artigo se propõe a analisar as implicações decorrentes dos processos de avaliação vigentes no Ensino Secundário Geral do 2º ciclo – ESG2, em Moçambique. Teoricamente, mobilizaram-se as categorias sociológicas de educação, nomeadamente, os ritos de instituição/consagração social, e o capital cultural/linguístico. Tais conceitos assumiram um papel proeminente para o desvelamento da essência dos princípios que subjazem o Regulamento de Avaliação adotado no ESG2. Metodologicamente, trata-se de um estudo de natureza qualitativa com alguns retoques quantitativos, servindo-se do método hermenêutico, o qual possibilitou a análise das fontes bibliográficas e documentais inerentes à educação moçambicana. Os argumentos aqui discorridos sugerem o estabelecimento de políticas educacionais mais condizentes à precariedade social e ao capital cultural/linguístico que marcam a grande maioria de alunos, assim como à promoção da desejável inclusão e justiça escolar no interior do sistema de ensino, prevista legalmente.
Por uma Educação do Campo com as vozes da luta pela terra
Authors: Pereira Andreia dos Santos , Possas Hiran de Moura
Published: January 2022

O artigo trata da importância de poéticas orais dos moradores do Projeto de Assentamento Grande Vitória, Marabá, Pará, como formação política no ensino de Língua Portuguesa e suas Literaturas, na Escola Família Agrícola Jean Hébette. As informações advêm de pesquisa realizada no curso de licenciatura em Educação do Campo, da Universidade Federal do Sul e Sudeste do Pará. Metodologicamente, foram consultados aportes teóricos interdisciplinares e realizadas entrevistas com agricultores do Projeto de Assentamento orientadas pela História Oral. As poéticas orais evocam temáticas dos modos de vida do campesinato: migração, resistência à violência no campo e conflitos entre projetos do capitalismo internacional e as populações tradicionais. Como resultados e encaminhamentos, compreende-se a necessidade de reafirmação dos atributos políticos do ensino do campo em diálogos críticos com historiografias linguísticas, literárias, canônicas e não canônicas.
Antibacterial Activity of Mangrove Root Extracts from Ngurah Rai Mangrove Forest, Denpasar-Bali
Authors: Wijaya Made Dharmesti , Indraningrat Anak Agung Gede
Published: January 2022

The increasing rate of antimicrobial resistance in the past decades has motivated the search for novel antibacterial compounds to overcome infectious diseases. Among diverse natural sources, mangrove ecosystems offer untapped sources of biological active compounds for future antibacterial medicine. This research was aimed to evaluate antibacterial activities of crude extracts of four dominant mangrove plants from the Ngurah Rai Mangrove Forest namely Rhizophora mucronata, Avicennia marina, Rhizophora apiculata, and Sonneratia alba. Roots of these four plants were extracted using methanol, chloroform, and n-hexane. These crude extracts were tested against two Gram positive bacteria (Staphylococcus aureus and Streptococcus mutans) and two Gram negative bacteria (Escherichia coli dan Klebsiella pneumoniae) by disc difussion assay. We found that 3 mg/mL of N-hexane crude extracts from R. apiculata yielded the highest zone of inhibition of 8.64 mm against S. aureus. While, 3 mg/mL of chloroform crude extract of R. apiculata yielded the highest inhibition of 19.83 mm against S. mutans. Unfortunately, no zone of inhibition was observed when crude extracts were tested against Gram negative indicator strains. Our results indicate that the root crude extracts of R. apiculata yielded the highest zone of inhibition against Gram positive indicator strains compared to root crude extracts of R. mucronata, S. alba, and A. marina. Further research is required to determine the antibacterial activities of the mangrove crude extracts against other bacterial indicator strains to determine their spectrum of activities.
Risk Assessment of Heavy Metals in Chromolaena odorata Collected Around Gemstone Mining Site in Ijero-Ekiti
Authors: Abiya Efe Sylvanus , Ologundudu Foluso Akinbode , Wisdom Ekpo
Published: January 2022

In Nigeria, like many developing nations, the resultant effect of land degradation: aggravated soil erosion, flood disasters, salinization or alkalisation, and the desertification have been a major public health concern for the past decades, however this study highlighted some of the factors that leads to the menace of soil fertility. The study was conducted at a gemstone mining site in Ijero Ekiti, Ekiti State, Nigeria. The soil samples were collected at a depth of 0-15 cm top soil and 0-30 cm subsoil. A line transect of 20 cm was drawn and soil sample was collected, all samples were kept in a clean container and labeled accordingly before been transported to the laboratory for analysis. The plant samples were thoroughly washed with distilled water to remove dust and other particles, air dried in a dust free wire meshed cage. All data obtained from this research were subjected to one-way analysis of variance (ANOVA). The result obtained in this study indicated that the levels of heavy metal concentration tested were still within the permissible limit in the root and shoot of Chromolaena odorata between the mine and control site. The implication of this is that Chromolaena odorata is safe for human and animal consumption. The said plant can readily undergo photosynthetic activity to aid growth by exploiting the presence of these metals either as a macro-nutrient or micro-nutrient as seen from the Translocation Factor and Metal Transfer Factor. The study concludes that soil at Ijero-Ekiti mine site were slightly acidic soil pH, reduced organic carbon, total nitrogen, available phosphorus, exchangeable cations and averagely elevated heavy metal contents.
Pengaruh Motivasi Keluarga Terhadap Kemampuan Kognitif Anak Usia 5-6 Tahun: Studi Masa Pandemi
Authors: Afsari Fanny , Rusdiyani Isti , Khosiah Siti
Published: January 2022

During the pandemic, children aged 5-6 years need time to learn from home so that cognitive abilities during the pandemic experience obstacles. Family motivation has an important role in empowering children's cognitive abilities. The purpose of this study was to determine the effect of family motivation on the cognitive abilities of children aged 5-6 years during the pandemic. The research method used is quantitative. The research subjects found 60 children consisting and 60 parents of: grades B1, B2, B3, B4 at the Putera Bhineka Institute. Data collection techniques using observation, questionnaires, and documentation. The validity and reliability test showed that all the item instruments used were valid and reliable. Data analysis using SPSS 22.0 with simple linear regression test based on hypothesis testing. The results showed that there was no significant effect of motivation on children's cognitive abilities during the pandemic aged 5-6 years. The results of calculations with simple linear regression analysis and hypothesis testing can be said that tcount is 1.311 and a significance value is 0.195. The significant value is 0.195 > 0.05 or seen in the tcount of 1.311 < ttable 2.001. These results can be influenced by environmental factors in the community and the school environment. The findings of this study contribute that during the pandemic, children's cognitive abilities are not influenced by family motivation, but rather by environmental and other factors.
PROBLEMATIC FEATURES OF THE REHABILITATION PROCESS AT ITS MEDICAL STAGE
Authors: Guseva N. K. , Berdutin V. A.
Published: January 2022

Rehabilitation, as a system of medical, psychological, socio-economic measures aimed at eliminating or possibly fully compensating for disabilities, is of great importance in the social protection of disabled people and the prevention of disability. In the article, based on the analysis of the current legislative and regulatory acts, scientific articles on the topic of rehabilitation and our own research, it is shown that there is no proper correspondence between the theory of rehabilitation, regulations and the organization of the rehabilitation process in medical institutions. The authors have proposed a number of ideas and activities that, in their opinion, should help in resolving existing inconsistencies and contradictions.
GSTARI-ARCH MODEL AND APPLICATION ON POSITIVE CONFIRMED DATA FOR COVID-19 IN WEST JAVA
Authors: Alawiyah Mutik , Kusuma Dianne Amor , Ruchjana Budi Nurani
Published: January 2022

Time series model that is commonly used is the Box-Jenkins based time series model. Time series data phenomena based on Box-Jenkins can be combined with spatial data, it is called the space time model One model based on Box-Jenkins model with heterogeneous location characteristics is the Generalized Space Time Autoregressive Integrated (GSTARI) model for a model that assumes data is not stationary or has a trend. This paper discusses the development of the GSTARI model with the assumption that the error variance is not constant which is applied to positive data confirmed by Covid-19 in West Java Province, especially in 4 regencies/cities that have cases in the high category from 6 March 2020 until 31 December 2020. Four regencies/cities are Depok City, Bekasi City, Bekasi Regency, and Karawang Regency. Parameter estimation method for the assumption of non-constant error variance can use Autoregressive Conditional Heteroscedasticity (ARCH) method. GSTARI-ARCH modeling procedure followed three Box-Jenkins stages, namely the identification process, parameter estimation and checking diagnostic. Application of the GSTARI-ARCH Model to Covid-19 positive confirmed data in 4 regencies/cities has a minimum value of RMSE in Bekasi City. The plot of forecast results for the four regencies/cities has a similar pattern to the actual data only applicable for a short time for 1-2 days.
RELATIVE RISK OF CORONAVIRUS DISEASE (COVID-19) IN SOUTH SULAWESI PROVINCE, INDONESIA: BAYESIAN SPATIAL MODELING
Authors: Aswi Aswi , Mauliyana Andi , Tiro Muhammad Arif , Bustan Muhammad Nadjib
Published: January 2022

The Covid-19 has exploded in the world since late 2019. South Sulawesi Province has the highest number of Covid-19 cases outside Java Island in Indonesia. This paper aims to determine the most suitable Bayesian spatial conditional autoregressive (CAR) localised models in modeling the relative risk (RR) of Covid-19 in South Sulawesi Province, Indonesia. Bayesian spatial CAR localised models with different hyperpriors were performed adopting a Poisson distribution for the confirmed Covid-19 counts to examine the grouping of Covid-19 cases. All confirmed cases of Covid-19 (19 March 2020-18 February 2021) for each district were included. Overall, Bayesian CAR localised model with G = 5 with a hyperprior IG (1, 0.1) is the preferred model to estimate the RR based on the two criteria used. Makassar and Toraja Utara have the highest and the lowest RR, respectively. The group formed in the localised model is influenced by the magnitude of the mean and variance in the count data between areas. Using suitable Bayesian spatial CAR localised models enables the identification of high-risk areas of Covid-19 cases. This localised model could be applied in other case studies.
Metodika zajištění kvality otevřených vzdělávacích zdrojů pro vysokoškolské vzdělávání
Authors: Dlouhá Jana , Petiška Eduard , Pospíšilová Marie , Dlouhý Jiří , Korhoňová Lucie
Published: January 2022

V rámci metodiky popisujeme jak správně využívat a vytvářet kvalitní otevřené vzdělávací zdroje (OER), přičemž se zaměřujeme na zdroje na bázi MediaWiki softwaru, jež se označují také jako wiki systémy. Zabýváme se také otázkou, jaké předpoklady pro tvorbu kvalitních online zdrojů je nutné zajistit, např. po stránce obsahu, práce redakčního týmu, technických parametrů prostředí atd. Metodika je určena jak těm, kdo vzdělávací materiály tohoto typu tvoří a chtějí se dozvědět jaké předpoklady by měly být splněny pro zajištění kvality, tak i těm, kdo tyto materiály užívají, vzhledem k tomu, že jim může pomoci při orientaci v informačním prostředí.
Inicjatywa lokalna – niewykorzystany potencjał czy skuteczny instrument aktywizacji obywateli w rozwiązywaniu problemów lokalnych? Przykład Łodzi
Authors: Grzyś Patrycja
Published: January 2022

Realizacja badań podjętych w ramach niniejszej pracy ma służyć celowi nadrzędnemu, jakim jest rozpoznanie potencjału inicjatywy lokalnej w kontekście aktywizacji społeczności lokalnych Łodzi. Główną metodą badawczą było studium przypadku oparte zarówno na analizie danych ilościowych dotyczących realizacji zadań w ramach inicjatyw lokalnych podejmowanych w Łodzi w latach 2013–2019, jak i analizie danych jakościowych (analizie treści) poszczególnych projektów, które zostały w tym czasie zrealizowane. Analiza ta umożliwia po pierwsze określenie skali wykorzystania wymienionego narzędzia w procesie współkształtowania przestrzeni miejskich przez społeczności lokalne, a po drugie, wskazanie podstawowych rodzajów działań podejmowanych przez mieszkańców, co pozwala na identyfikację ich podstawowych potrzeb i problemów, a przede wszystkim propozycji na ich zapewnienie lub rozwiązanie.
K ETYMOLOGIJI PSŁ. *SLĚPЪ/SLEPЪ
Authors: WORNAR EDWARD
Published: January 2022

This article explains the hitherto unexplained variation of the root *slep/slěp- ‘blind’ which results from an old opposition of the causative (lengthened grade) vs. regular root (regular grade). This indicates a connection with the Lithuanian silpnas as a zero-grade root for the Slavic word which previously had no convincing parallels in other languages. Semantically, a connection with words meaning ‘sticky’ (as postulated by Šewc 1978 and others) should be rejected: they are neither phonetically nor semantically convincing. The preference is for the interpretation of blindness as a special kind of weakness.
Huntington disease update: new insights into the role of repeat instability in disease pathogenesis
Authors: Arning Larissa , Nguyen Huu Phuc
Published: January 2022

The causative mutation for Huntington disease (HD), an expanded trinucleotide repeat sequence in the first exon of the huntingtin gene (HTT) is naturally polymorphic and inevitably associated with disease symptoms above 39 CAG repeats. Although symptomatic medical therapies for HD can improve the motor and non-motor symptoms for affected patients, these drugs do not stop the ongoing neurodegeneration and progression of the disease, which results in severe motor and cognitive disability and death. To date, there is still an urgent need for the development of effective disease‐modifying therapies to slow or even stop the progression of HD. The increasing ability to intervene directly at the roots of the disease, namely HTT transcription and translation of its mRNA, makes it necessary to understand the pathogenesis of HD as precisely as possible.

In addition to the long-postulated toxicity of the polyglutamine-expanded mutant HTT protein, there is increasing evidence that the CAG repeat-containing RNA might also be directly involved in toxicity. Recent studies have identified cis- (DNA repair genes) and trans- (loss/duplication of CAA interruption) acting variants as major modifiers of age at onset (AO) and disease progression. More and more extensive data indicate that somatic instability functions as a driver for AO as well as disease progression and severity, not only in HD but also in other polyglutamine diseases. Thus, somatic expansions of repetitive DNA sequences may be essential to promote respective repeat lengths to reach a threshold leading to the overt neurodegenerative symptoms of trinucleotide diseases. These findings support somatic expansion as a potential therapeutic target in HD and related repeat expansion disorders.
Suggested Method of Specimen Preparation for Triaxial Tests on Partially Saturated Sand
Authors: Zeybek Abdülhakim
Published: January 2022

In geotechnical engineering, triaxial testing is widely adopted to evaluate the mechanical behavior of sand. Methods of specimen preparation for triaxial tests on dry and completely saturated sand are well established in the literature, whereas very little guidance exists on the preparation of partially saturated sand at relatively high degrees of saturation (typically Sr > 80 %). The purpose of this study is to elucidate the suitable method of specimen preparation for partially saturated sand using sodium percarbonate and investigate the effects of partial saturation on the undrained cyclic behavior of sand. Loosely and densely packed specimens are prepared in a dynamic triaxial apparatus through dry pluviation and tamping of sand. For tests on fully saturated sand, dry specimens are flushed with carbon dioxide and deaired water and saturated applying back pressure. For tests on partially saturated sand, sodium percarbonate is used in either fine powder or aqueous solution form to create oxygen bubbles in the voids, reducing the degree of saturation of specimens. The results suggest that not only the degree of saturation but also the way partially saturated specimens are prepared affects the liquefaction resistance. At the same level of saturation and principal stress difference, specimens prepared with the aqueous solution exhibit higher liquefaction resistance than those prepared with the powder. The solution of sodium percarbonate proves to be a more reliable and repeatable technique for preparing partially saturated triaxial specimens with relatively high degrees of saturation.
KCTD8 and KCTD12 Facilitate Axonal Expression of GABABReceptors in Habenula Cholinergic Neurons
Authors: Ren Yuqi , Liu Yang , Zheng Sanduo , Luo Minmin
Published: January 2022

GABABreceptors in habenula cholinergic neurons mediate strong presynaptic excitation and control aversive memory expression. K+channel tetramerization domain (KCTD) proteins are key interacting partners of GABABreceptors; it remains unclear whether and how KCTDs contribute to GABABexcitatory signaling. Here, we show that KCTD8 and KCTD12 in these neurons facilitate the GABABreceptors expression in axonal terminals and contribute to presynaptic excitation by GABABreceptors. Genetically knocking outKCTD8/12/16orKCTD8/12, but not other combinations of the threeKCTDisoforms, substantially reduced GABABreceptors–mediated potentiation of glutamate release and presynaptic Ca2+entry in response to axonal stimulation, whereas they had no effect on GABAB-mediated inhibition in the somata of cholinergic neurons within the habenulo–interpeduncular pathway in mice of either sex. The physiological phenotypes were associated with a significant decrease in the GABABexpression within the axonal terminals but not the somata. Overexpressing either KCTD8 or KCTD12 in theKCTD8/12/16triple knock-out mice reversed the changes in axonal GABABexpression and presynaptic excitation. In mice lacking the KCTDs, aversion-predicting cues produced stronger neuronal activation in the interpeduncular nucleus, and the infusion of GABABagonist in this nucleus produced a weaker effect on fear extinction. Collectively, our results reveal isoform-specific roles of KCTD proteins in enriching the axonal expression of GABABreceptors, facilitating their presynaptic signaling, and modulating aversion-related memory processes.

SIGNIFICANCE STATEMENTGABABreceptors represent the principal inhibitory neurotransmitter receptor, but they mediate strong presynaptic excitation in the habenulo–interpeduncular pathway and modulate aversion memory expression. KCTD proteins are integral constituents of GABABreceptors. By analyzing the physiological, neuroanatomical, and behavioral phenotypes of multiple KCTD knock-out mouse lines, we show that KCTD8 and KCTD12 facilitate the axonal expression and hence presynaptic excitation of GABABreceptors in habenula cholinergic neurons and control cued-aversion memory formation and expression in the habenulo–interpeduncular pathway. These results expand the physiological and behavioral functions of KCTDs in modulating the brain neural circuits.
Cardio-psycho-metabolic outcomes of bariatric surgery: design and baseline of the WAS trial
Authors: Koschker Ann-Cathrin , Warrings Bodo , Morbach Caroline , Seyfried Florian , Rickert Nicole , Jung Pius , Geier Andreas , Dischinger Ulrich , Krauthausen Maike , Herrmann Martin J , Stier Christine , Frantz Stefan , Malzahn Uwe , Störk Stefan , Fassnacht Martin , _ _
Published: January 2022

Obesity is a rapidly emerging health problem and an established risk factor for cardiovascular diseases. Bariatric surgery profoundly reduces body weight and mitigates sequelae of obesity. The open, randomized controlled Würzburg Adipositas Studie (WAS) trial compares the effects of Roux-en-Y gastric bypass (RYGB) vs psychotherapy-supported lifestyle modification in morbidly obese patients. The co-primary endpoint addresses 1-year changes in cardiovascular function (peak VO2 during cardiopulmonary exercise testing) and the quality of life (QoL) (Short-Form-36 physical functioning scale). Prior to randomization, all included patients underwent a multimodal anti-obesity treatment for 6–12 months. Thereafter, the patients were randomized and followed through month 12 to collect the primary endpoints. Afterwards, patients in the lifestyle group could opt for surgery, and final visit was scheduled for all patients 24 months after randomization. Sample size calculation suggested to enroll 90 patients in order to arrive at minimally 22 patients per group evaluable for the primary endpoint. Secondary objectives were to quantify changes in body weight, left ventricular hypertrophy, systolic and diastolic function (by echocardiography and cardiac MRI), functional brain MRI, psychometric scales, and endothelial and metabolic function. WAS enrolled 93 patients (72 women, median age 38 years, BMI 47.5 kg/m2) exhibiting a relevantly compromised exercise capacity (median peakVO2 18.3 mL/min/kg) and the QoL (median physical functioning scale 50). WAS is the first randomized controlled trial focusing on the effects of RYGB on cardiovascular function beyond hypertension. In addition, it will provide a wealth of high-quality data on the cerebral, psychiatric, hepatic, and metabolic function in obese patients after RYGB.
Arthrodesis of the proximal interphalangeal joint of the finger – a systematic review
Authors: Millrose Michael , Gesslein Markus , Ittermann Till , Kim Simon , Vonderlind Hans-Christoph , Ruettermann Mike
Published: January 2022

Arthrodesis of the proximal interphalangeal (PIP) joint of the finger is an established procedure for advanced osteoarthritis. As there are different techniques of fusion, it seems necessary to evaluate the results.

Primary outcome of this review was to evaluate different arthrodesis methods of the PIP joint and describe different numbers of non-unions. Secondary outcome was to evaluate time to consolidation. Respective complications, if mentioned, were listed additionally.

The review process was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The selected databases were PubMed, Medline, Embase, Google Scholar and Cochrane Library. Studies reporting outcomes of the arthrodesis with a defined technique and radiological consolidation were included. Complication rates and types were recorded. In total, 6162 articles could be identified, 159 full-texts were assessed and 64 studies were included. Methodological quality was assessed using Methodological Index for Non-Randomized Studies.

A total of 1923 arthrodeses of the PIP joint could be identified. Twelve different surgical techniques were described, four of these techniques with compression at the arthrodesis site. The most frequently used techniques were K-wires (n = 743, 14 studies), tension-band (n = 313, 15 studies) and compression screws (n = 233, 12 studies). The lowest rate of described non-unions in compression techniques was 3.9% with the compression screw. The highest non-union rate of 8.6% was achieved by interosseous wiring.

All the described techniques can achieve the goal of fusing an osteoarthritic joint. There is a tendency in the more recent literature for the use of compression techniques.
Spironolactone is associated with reduced mitotane levels in adrenocortical carcinoma patients
Authors: Haberbosch Linus , Maurer Lukas , Sandforth Arvid , Wernicke Charlotte , Spranger Joachim , Mai Knut , Jumpertz von Schwartzenberg Reiner
Published: January 2022

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Mitotane, a derivative of the pesticide dichlorodiphenyltrichloroethane, has been used successfully as first line chemotherapy since the 1960s, if maintained within a narrow therapeutic window. Spironolactone (SPL) is frequently used to treat glucocorticoid excess-associated adverse effects such as severe hypokalemia. Although data of a previous case report indicate a link, valid data regarding SPL use and mitotane plasma concentrations in a human cohort are lacking.This retrospective analysis includes data from 54 mitotane-receiving ACC patients (14 co-administered with SPL) treated between January 2005 and April 2020 (20 male, mean age 54.1 ± 2.2 years). All available mitotane concentrations, treatment doses, tumor stage and evidence of hormone activity were collected. Primary outcomes included mitotane levels and concentration/dose ratios as well as time-in-range (TR) in patients with and without additional SPL treatment. The SPL group was characterized by higher glucocorticoid secretion. Other features such as tumor stage, size and anthropometrics were similar between groups. Interestingly, the SPL group had significantly lower mitotane levels despite higher doses. Mitotane TR was significantly reduced in the SPL group, as was time-in-range to progression. These data provide first evidence in a human cohort for potential SPL-mitotane interactions (beyond mentioned case report), which affect dose response and may modulate treatment outcomes. This should caution clinicians to carefully adjust mitotane doses during SPL treatment in ACC patients or choose alternative therapeutic options.
The Development of Home-School Partnership Courses: A Practice Based on Xingzhi Tao’s Life Education Theory
Authors: Zhao Fengping , Wei Chuanguo
Published: January 2022

Home-school partnership plays a critical role in student growth and the home-school partnership courses provide important paths to achieving ideal results of the partnership. Under the guidance of the three principles of “life is education”, “society is school” and “integrating teaching, learning and practice” in Xingzhi Tao’s life education theory, Shandong 271 Education Group developed the parent school course and the family civilization course, which turn out to be a systematic support for the home-school partnership program. This paper analyses the status quo of home-school cooperation in China and focuses elaborations on the components and practice of the two courses in Shandong 271 Education Group.
Influence of forest vegetation on color, reflectivity and humus content in soils of northern variant ravines of the steppe zone of Ukraine
Authors: Gorban V. A. , Yakuba M. S. , Huslystyi A. O.
Published: January 2022

Unique natural forests grow in the conditions of ravines of the steppe zone of Ukraine. Soil scientists have been researching the soils of ravines for more than 60 years. Despite long-term research, aspects of the genesis of specific ravine soils, which are reflected in their optical properties, are still virtually unexplored. Based on this, the aim of our work is to establish the characteristics of the influence of forest vegetation on color and reflectivity, as well as the closely related content of humus in the soils of the northern variant ravines of the steppe zone of Ukraine. Soil samples were taken from each genetic horizon of sections laid in the Glybokyy ravine (near the village of Andriivka, Novomoskovsk district, Dnipropetrovsk region). Soil color indices were determined by scanning soil samples followed by image analysis. The reflectivity of soils was investigated using a monochromator. The humus content in soils was determined by the standard method of wet oxidation of organic matter according to I. V. Tyurin. As a result of the performed researches it is established that the upper horizons of the soils of the Glybokyy ravine differ in the reduced values ​​of the indicators of the HSB, RGB and Lab systems, with depth their values ​​increase. The upper horizons of the ravine soils are characterized by reduced values ​​of brightness coefficients at wavelengths of 480, 650 and 750 nm, as well as the integrated brightness coefficient, with depth there is a gradual increase in their values. The color indicators of the RGB and Lab systems are the most successful for diagnosing and predicting the humus content in the soils of the ravine. Forest chernozems and forest-meadow soil of the ravine, which were formed under natural forest vegetation, are characterized by reduced values ​​of color indicators of HSB, RGB and Lab systems, reduced values ​​of brightness coefficients and increased humus content compared to chernozems, the genesis of which is related.
ЖУЖЕЛИЦЫ (COLEOPTERA: CARABIDAE) МЕЗИНСКОГО НАЦИОНАЛЬНОГО ПРИРОДНОГО ПАРКА (ЧЕРНИГОВСКАЯ ОБЛАСТЬ, УКРАИНА)
Authors: Sheshurak P. N. , Nazarov N. V.
Published: January 2022

Приведён список жужелиц (Coleoptera: Carabidae) (223 вида), выявленных на территории Мезинского НПП, с указанием места и времени сбора, краткие сведения по экологии, с указанием фенологических данных. В списке приводится 8 видов новых для Черниговщины, для 24 видов впервые приводятся достоверные этикеточные даные с территории области, 85 видов впервые указываются для территории Парка, 5 регионально-редких видов требуют охраны на Черниговщине.