bluuebunny/crossref_metadata_2025 huggingface dataset:
gcodeml: A Grid-enabled Tool for Detecting Positive Selection in Biological Evolution
Authors: Moretti Sébastien  , Murri Riccardo  , Maffioletti Sergio  , Kuzniar Arnold  , Castella Briséïs  , Salamin Nicolas  , Robinson-Rechavi Marc  , Stockinger Heinz
Published: February 2025

One of the important questions in biological evolution is to know if certain changes along protein coding genes have contributed to the adaptation of species. This problem is known to be biologically complex and computationally very expensive. It, therefore, requires efficient Grid or cluster solutions to overcome the computational challenge. We have developed a Grid-enabled tool (gcodeml) that relies on the PAML (codeml) package to help analyse large phylogenetic datasets on both Grids and computational clusters. Although we report on results for gcodeml, our approach is applicable and customisable to related problems in biology or other scientific domains.
Federated Queries for Comparative Effectiveness Research: Performance Analysis
Authors: Price Ronald C.  , Huth Derick  , Smith Jody  , Harper Steve  , Pace Wilson  , Pulver Gerald  , Kahn Michael G.  , Schilling Lisa M.  , Facelli Julio C.
Published: February 2025

This paper presents a study of the performance of federated queries implemented in a system that simulates the architecture proposed for the Scalable Architecture for Federated Translational Inquiries Network (SAFTINet). Performance tests were conducted using both physical hardware and virtual machines within the test laboratory of the Center for High Performance Computing at the University of Utah. Tests were performed on SAFTINet networks ranging from 4 to 32 nodes with databases containing synthetic data for several million patients. The results show that the caGrid FQE (Federated Query Engine) is capable and suitable for comparative effectiveness research (CER) federated queries given its nearly linear scalability as partner nodes increase in number. The results presented here are also important for the specification of the hardware required to run a CER grid.
1 World Trade Center – Podium Wall Design Development
Authors: Timm Christoph
Published: February 2025

On the new 1 World Trade Center Tower an exterior permeable façade treatment was to be designed for the lower 20 floors cladding a concrete shear wall and mechanical louvers. Engineering and design had to be balanced with the client's desire to streamline maintenance issues for the tallest office building in the western hemisphere. The scope of the podium façade treatment includes over 12.000 m2 in total area with more than 4.000 glass fins each free spanning 4m in height between attachments. Various glass fin-metal connection details were evaluated for aesthetic and performance criteria.
Investigation of Stress-Whitening in Transparent Structural Silicone Adhesive
Authors: Hagl Anneliese  , Wolf Andreas  , Sitte Sigurd
Published: February 2025

The stress whitening behavior of a transparent structural silicone adhesive (TSSA) under tensile and shear loading is investigated in this paper. The TSSA material has been developed for point-fixing in glazing and combines high transparency, strong adhesion performance, thermal stability and excellent weatherability. The transparent film adhesive is a heat curing one-part material that shows strong bonding to glass, metals, ceramics and even plastics typically without primer.
New Expressions for the Effective Thickness of Laminated Glass
Authors: Galuppi Laura  , Royer-Carfagni Gianni
Published: February 2025

The deformability of the interlayer does not provide a perfect shear transfer between the glass plies, so that flexural response of laminated glass is somehow intermediate between that of a monolith and that of free-sliding plies. In the design practice, this effect is usually taken into account through the definition of the Effective Thickness (ET), i.e., the thickness of a monolith with equivalent bending properties. Classical formulas for the ET have been proposed by Bennison et al. [1], based on the original analysis by Wölfel [2]. Here, we propose new expressions for the ET based upon strain energy minimization. Practical formulas are derived which apply to the one-dimensional case of beams, as well as to the two-dimensional case of laminated plates. The better efficiency of the proposed method with respect to others is proved by the comparison with accurate three-dimensional numerical simulations.
Influence of the Load History on the Edge Strength of Glass with Cut Edge Finishing
Authors: Vandebroek Marc  , Belis Jan  , Louter Christian
Published: February 2025

The edge strength of glass is affected by the load history: i.e. the load duration and the loading type, e.g. constant loading, cyclic loading or linearly increasing loading. In standards, these influences are expressed by the factor kmod, which reduces the strength depending on the load type, e.g. wind load, temperature load. In this study, five series of glass specimens with a cut edge finishing were subjected to in-plane four-point bending tests. First, the specimens were subjected to a linearly increasing loading. Then identical specimens were subjected to either a constant loading or a cyclic loading or both. These test results were compared to the theoretical prediction, based on the theory of fracture mechanics, as well as to the guidelines of the standards.
Flow Control by Plasmas in the PLASMAERO Project
Authors: Caruana Daniel
Published: February 2025

With the continued objective of increasing aircraft performances whilst reducing the environmental impact, research is being carried out to find innovative solutions to influence air flow using simple actuators. If the aerodynamic configu-ration of future aircraft could be modified in real time in flight, then the aircraft's performance could be continually adapted to provide optimum aerodynamic characteristics. Among the innovative solutions, the use of plasma technologies has shown itself to be very promising from both a performance point of view and in terms of the diversity in potential applications from external and internal flow control, combustion, enhancement and noise attenuation. The main advantages of plasmas devices are their manufacturing and integration simplicity, low power consumption, ability for real time control at high frequency and their robustness.
SWAFEA: A European Study on the Feasibility and Impact of the Introduction of Alternative Fuelsin Aviation
Authors: Novelli Philippe
Published: February 2025

Committed to taking an active role in climate change mitigation and in the promotion of secure and sustainable energy sources, the European Commission's Directorate General for Mobility and Transport initiated the SWAFEA – Sustainable Way for Alternative Fuels and Energy for Aviation – study in February 2009 to investigate the feasibility and impacts of the use of alternative fuels in aviation. Alternatives to crude oil-based kerosene are seen as an important component in the efforts to reach the target set by the European Directive for Renewable Energy (RED, [1]) to introduce 10% of renewable energy in transport by 2020. It's also an important development with view to the introduction of aviation in the ETS from 2012 [2].The study was to develop a comparative analysis of different fuels and energy-carrier options for aviation on the basis of current knowledge, and to propose a possible vision and roadmap for their deployment in order to facilitate and support future policy decisions. The SWAFEA study, which delivered its findings and recommendations in April 2011 [3],1 encompassed all aspects of the possible introduction of alternative fuels in aviation using a highly multidisciplinary approach. This included technical, environmental, and economic assessments. The study was carried out under the leadership of the French Aerospace Research Lab ONERA, in cooperation with a consortium of twenty partners2 bringing together European research organisations and representatives of virtually every major stakeholder in the aviation fuel chain.
Speech by Giuseppe Orsi, AgustaWestland
Authors: Orsi Giuseppe
Published: February 2025

The considerations addressed in ‘Flightpath 2050’ are shared by the entire Rotorcraft Community. The author's vision is this: by 2050, vertical flight shall be a mode of flying of a significant percentage of future aircraft, a portion of the continuum of flying activity. So, leveraging on vertical flight state-of-the-art technology will mean to improve mobility within and across our countries.
Coordination of Aeronautics Interest in the EU Member States
Authors: Romero Javier  , Gurály Roland
Published: February 2025

This paper introduces the efforts of the European Member States, obviously in line with ACARE goals, in terms of technology platforms and strategies. In order to better understand the implementation of these goals on national level a survey was launched in 2009 by the ACARE Member States Group. The outcome of this survey is also included in this paper.
An improved kinematic model of the spine for three-dimensional motion analysis in the Vicon system
Authors: Długosz Mirosława M.  , Panek Daria  , Maciejasz Paweł  , Chwała Wiesław  , Alda Witold
Published: February 2025

The mechanism of creation and pathomechanics of lateral spinal deformation is still not fully explained. Modern medical imaging techniques give scientists possibility to understand some aspects, but vast majority of those techniques is based on static trials. A motion capture system belongs to techniques which enable visualization of a spine during dynamic trials; however, due to lack of appropriate computational model, it is unsuitable for scoliosis imaging.
Inclusion Criteria for Physical Therapy Intervention Studies on Scoliosis – a Review of the Literature
Authors: Weiss HR
Published: February 2025

There is a wide variation of the inclusion criteria found in studies investigating the outcome of conservative scoliosis treatment. While the application of the SRS criteria for studies on bracing seem useful, there are no inclusion criteria for the investigation of physiotherapy alone. This study has been performed to investigate the possibility to find useful inclusion criteria for future prospective studies on physiotherapy (PT).
The influence of the degree of spine curvature on the quality of life assessment among patients treated surgically with the Cotrel-Dubousset method
Authors: Gorzkowicz Bożena  , Kołban Maciej
Published: February 2025

Physical appearance and psychomotor ability rank high in the hierarchy of values accepted by children and teenagers. Therefore Idiopathic Scoliosis (IS), which is accompanied by the dysfunction of locomotive organ and often requires troublesome treatment, may lead to poor body image and frustration. Other common effects are a low self-esteem, identity problems and depressive symptoms.
Mobile Health Apps – From Singular to Collaborative
Authors: Fox Ronan  , Cooley James  , McGrath Matthew  , Hauswirth Manfred
Published: February 2025

Mobile health apps are proliferating, but they fail to deliver on a key patient and caregiver requirement – the ability to collaborate using key phone features while leveraging existing web services. Typically, mobile health apps are for single use, proprietary, and deliver closed-world solutions. By making use of web services, both open and proprietary, mobile health apps can be created to support the caregiver network in the community. The full value of telehealth will only be achieved when the spectrum of trusted health care services (preventive, promotion, curative, and rehabilitative) is delivered to the collaborating network of caregivers.
User Clustering in Smartphone Applications
Authors: Schaefers Klaus  , Ribeiro David
Published: February 2025

In the context of mobile health applications usability is a crucial factor to achieve user acceptance. The successful user interface (UI) design requires a deep understanding of the needs and requirements of the targeted audience. This paper explores the application of the K-Means algorithm on smartphone usage data in order to offer Human Computer Interaction (HCI) specialists a better insight into their user group. Two different feature space representations are introduced and used to identify persona like stereotypes in a real world data set, which was obtained from a public available smartphone application.
The University of NSW electronic Practice Based Research Network: Disease registers, data quality and utility
Authors: Taggart J.  , Liaw S.T.  , Dennis S.  , Yu H.  , Rahimi A.  , Jalaludin B.  , Harris M.
Published: February 2025

Introduction: Accurate well-maintained registers are a prerequisite to co-ordinated care of patients with chronic diseases. Their effectiveness in enabling improved management is dependent on the quality of the information captured. This paper provides an overview into the methodology and data quality of the electronic Practice Based Research Network.
The impact of OCR accuracy on automated cancer classification of pathology reports
Authors: Zuccon Guido  , Nguyen Anthony N.  , Bergheim Anton  , Wickman Sandra  , Grayson Narelle
Published: February 2025

Objective: To evaluate the effects of Optical Character Recognition (OCR) on the automatic cancer classification of pathology reports.
Capturing the Emotional Geographies of School Professionals Working with Children with Cancer
Authors: Rechis Ruth
Published: February 2025

Students diagnosed with cancer who return to school as quickly as possible are less likely to fall as far behind academically and are more likely to be reintegrated readily into the school social environment. For students to return to school successfully, a team of support may be required and should include school professionals. Traditionally, school professionals have received very little training on how to help students with cancer return to the school environment and working with such students can be an intense emotional experience. The present study explored the cognition, motivation, and emotion of school professionals working with students with cancer during the school re-entry process. Case studies were conducted to explore the participants' emotional experience as it related to helping students to return and reintegrate into the classroom environment.
Flexible Medical Image Management Using Service-Oriented Architecture
Authors: Shaham Oded  , Melament Alex  , Barak-Corren Yuval  , Kostirev Igor  , Shmueli Noam  , Peres Yardena
Published: February 2025

Management of medical images increasingly involves the need for integration with a variety of information systems. To address this need, we developed Content Management Offering (CMO), a platform for medical image management supporting interoperability through compliance with standards. CMO is based on the principles of service-oriented architecture, implemented with emphasis on three areas: clarity of business process definition, consolidation of service configuration management, and system scalability. Owing to the flexibility of this platform, a small team is able to accommodate requirements of customers varying in scale and in business needs. We describe two deployments of CMO, highlighting the platform's value to customers. CMO represents a flexible approach to medical image management, which can be applied to a variety of information technology challenges in healthcare and life sciences organizations.
A Way to Motivate Danish GPs to Implement a New National Service
Authors: Kristensen Alice  , Wengler Bente
Published: February 2025

The Common Medicine card (CMC) is a new national service in Denmark which aim is to ensure better patient care and minimize medication errors. All health professionals as well as authorities have to use this system. CMC requires changing the organization of work for both physicians and clinical staff in General Practice (GP). Commissioning of CMC in GP requires a significant effort beyond the technical installation of the solution. Finding the right way to implement a new service in a busy GP has been the main focus of the national project organization MedCom. MedCom has in collaboration with the five regions in Denmark, established a joint plan and has created an implementation model contraining various initiatives including “after hours” meetings for each service provider of EMR (Electronic Medicine Records) in order to disseminate and support the new CMC service. This paper shows the status of the “after hours” meetings effect in dissemination of CMC from August to November 2011.
Standard Based Multiclient Medical Data Visualization
Authors: Kopanitsa Georgy
Published: February 2025

An efficient interaction between a doctor and an electronic health record (EHR) depends also on the visual layer of an EHR. As users with various backgrounds and needs have different perspectives on the same data visualization methods must be flexible to provide the optimal interface. The ISO 13606 community is interested in developing requirements on a generic visualization method that can supplement the archetype model. Our research aims at specifying the requirements on a medical data visualization method based on the ISO13606 data model. XML allows a clear structuring and validation of the data due to the built-in standard features. The proposed visual medical concept allows separating the medical knowledge from the visualization knowledge. The research is focused defining the optimal XML schema for a visual medical concept to allow multiclient generic data presentation.
Classification and Prioritization of Biomedical Literature for the Comparative Toxicogenomics Database
Authors: Vishnyakova Dina  , Pasche Emilie  , Gobeill Julien  , Gaudinat Arnaud  , Lovis Christian  , Ruch Patrick
Published: February 2025

We present a new approach to perform biomedical documents classification and prioritization for the Comparative Toxicogenomics Database (CTD). This approach is motivated by needs such as literature curation, in particular applied to the human health environment domain. The unique integration of chemical, genes/proteins and disease data in the biomedical literature may advance the identification of exposure and disease biomarkers, mechanisms of chemical actions, and the complex aetiologies of chronic diseases. Our approach aims to assist biomedical researchers when searching for relevant articles for CTD. The task is functionally defined as a binary classification task, where selected articles must also be ranked by order of relevance. We design a SVM classifier, which combines three main feature sets: an information retrieval system (EAGLi), a biomedical named-entity recognizer (MeSH term extraction), a gene normalization (GN) service (NormaGene) and an ad-hoc keyword recognizer for diseases and chemicals. The evaluation of the gene identification module was done on BioCreativeIII test data. Disease normalization is achieved with 95% precision and 93% of recall. The evaluation of the classification was done on the corpus provided by BioCreative organizers in 2012. The approach showed promising performance on the test data.
Development and Representation of Health Indicators with Thematic Maps
Authors: Dalle Carbonare Simona  , Cerra Carlo  , Bellazzi Riccardo
Published: February 2025

Italian Local Health Care Agencies (ASLs) have the role of managing the public healthcare resources in their area of competence. To this end, the ASL of Pavia has implemented a data warehouse, which collects and integrates health data of more than 500,000 people since 2004. We have exploited such data repository to compute a variety of yearly health indicators, which have been represented on thematic maps of the area. Thanks to a Web-based application, the ASL decision-makers can monitor the area with a fine-grained spatial detail, dissecting the epidemiological, economical and pharmaceutical factors underlying citizens' health and patients' care. The implemented tool is currently up-and-running and has been evaluated with a usability questionnaire on a small number of users.
Efficient Medical Information Retrieval in Encrypted Electronic Health Records
Authors: Pruski Cédric  , Wisniewski François
Published: February 2025

The recent development of eHealth platforms across the world, whose main objective is to centralize patient's healthcare information to ensure the best continuity of care, requires the development of advanced tools and techniques for supporting health professionals in retrieving relevant information in this vast quantity of data. However, for preserving patient's privacy, some countries decided to de-identify and encrypt data contained in the shared Electronic Health Records, which reinforces the complexity of proposing efficient medical information retrieval approach. In this paper, we describe an original approach exploiting standards metadata as well as knowledge organizing systems to overcome the barriers of data encryption for improving the results of medical information retrieval in centralized and encrypted Electronic Health Records. This is done through the exploitation of semantic properties provided by knowledge organizing systems, which enable query expansion. Furthermore, we provide an overview of the approach together with illustrating examples and a discussion on the advantages and limitations of the provided framework.
Challenges in evaluating telehealth through RCT-the problem of randomization
Authors: Sharma Urvashi  , Reed Julie  , Doyle Cathal  , Bell Derek
Published: February 2025

Telehealth is heralded as a panacea to control burgeoning demand on healthcare resources and lack of streamlining in care delivery. However, evaluating the effectiveness of telehealth on health and care delivery outcomes through randomized controlled trials (RCTs) has been an issue of contention. This research investigates the issues that affect telehealth evaluation.
ICU Nurses' Evaluations of Integrated Information Displays on User Satisfaction and Perceived Mental Workload
Authors: Koch Sven H.  , Westenskow Dwayne  , Weir Charlene  , Agutter Jim  , Haar Maral  , Görges Matthias  , Liu David  , Staggers Nancy
Published: February 2025

Consolidated information from multiple sources (patient monitors, electronic medical records, infusion pumps, ventilators, medication references) may improve nurses' work and patient safety. Objective. Two hypotheses were tested, that integrated information displays (a) improve nurses' satisfaction and (b) lower perceived mental workload. Methods. In a counter-balanced, repeated measures design (integrated vs. traditional display) 12 ICU nurses performed realistic tasks using both display types. Results. Nurses' user interaction satisfaction was higher with the integrated display and it received more positive comments. Nurses' mean perceived mental workload scores were also lower, having significant differences in effort and frustration dimensions. A lower mental workload may reduce errors and improve treatment times. Integrated information displays have great promise, but technological factors such as bidirectional device communication must be addressed if these displays are to achieve their potential for improving patient safety.
Elicitating Patient Patterns of Physician Non-Compliance with Breast Cancer Guidelines Using Formal Concept Analysis
Authors: Bouaud Jacques  , Messai Nizar  , Laouénan Cédric  , Mentré France  , Séroussi Brigitte
Published: February 2025

Because they provide patient-specific guideline-based recommendations, clinical decision support systems (CDSSs) are expected to promote the implementation of clinical practice guidelines (CPGs). OncoDoc2 is a CDSS applied to the management of breast cancer. However, despite it was routinely used during weekly multidisciplinary staff meetings (MSMs) at the Tenon Hospital (Paris, France), the compliance rate of MSMs' decisions with CPGs did not reach 100%. Formal Concept Analysis (FCA) has been applied to elicit formal concepts related to non-compliance. A statistical pre-treatment of attributes has been proposed to leverage FCA and discriminate between compliant and non-compliant decisions. Among the 1,889 decisions made over a 3 year-period, 199 decisions of recommended re-excisions have been considered for analysis. In this sample, non-compliance was explained by uncommon clinical profiles and specific patient-centred clinical criteria.
Dicoogle Mobile: a medical imaging platform for Android
Authors: Viana-Ferreira Carlos  , Ferreira Daniel  , Valente Frederico  , Monteiro Eriksson  , Costa Carlos  , Oliveira José Luís
Published: February 2025

Mobile computing technologies are increasingly becoming a valuable asset in healthcare information systems. The adoption of these technologies helps to assist in improving quality of care, increasing productivity and facilitating clinical decision support. They provide practitioners with ubiquitous access to patient records, being actually an important component in telemedicine and tele-work environments. We have developed Dicoogle Mobile, an Android application that provides remote access to distributed medical imaging data through a cloud relay service. Besides, this application has the capability to store and index local imaging data, so that they can also be searched and visualized. In this paper, we will describe Dicoogle Mobile concept as well the architecture of the whole system that makes it running.
Designing and implementing a biobanking IT framework for multiple research scenarios
Authors: Prokosch Hans-Ulrich  , Mate Sebastian  , Christoph Jan  , Beck Andreas  , Köpcke Felix  , Stephan Stefanie  , Beckmann Matthias W.  , Rau Tilman  , Hartmann Arndt  , Wullich Bernd  , Breil Bernhard  , Eckardt Kai-Uwe  , Titze Stephanie  , Habermann Jens K.  , Ingenerf Josef  , Hackmann Michael  , Ries Markus  , Bürkle Thomas  , Ganslandt Thomas
Published: February 2025

This paper presents a biobanking IT framework, comprising a set of integrated biobanking information technology components. It provides adaptable and scalable IT support for varying biobanking scenarios, workflows and projects, while avoiding redundancy in data and technology. Feasibility of this approach is illustrated by implementations for four different biobanking projects at Erlangen University Hospital and with cooperating partners in Münster and Lübeck.
Standardizing Intensive Care Device Data to Enable Secondary Usages
Authors: Ingenerf Josef  , Kock Ann-Kristin  , Poelker Marcel  , Seidl Konrad  , Zeplin Georg  , Mersmann Stefan  , Handels Heinz
Published: February 2025

To represent medical device observations in a format that is consumable by clinical software, standards like HL7v3 and ISO/IEEE 11073 should be used jointly. This is demonstrated in a project with Dräger Medical GmbH focusing on their Patient Data Management System (PDMS) in intensive care, called Integrated Care Manager (ICM). Patient and device data of interest should be mapped to suitable formats to enable data exchange and decision support. Instead of mapping device data to target formats bilaterally we use a generic HL7v3 Refined Message Information Model (RMIM) with device specific parts adapted to ISO/IEEE 11073 DIM. The generality of the underlying model (based on Yuksel et al. [1]) allows the flexible inclusion of IEEE 11073 conformant device models of interest on the one hand and the generation of needed artifacts for secondary usages on the other hand, e.g. HL7 V2 messages, HL7 CDA documents like the Personal Health Monitoring Report (PHMR) or web services. Hence, once the medical device data are obtained in the RMIM format, it can quite easily be transformed into HL7-based standard interfaces through XSL transformations because these interfaces all have their building blocks from the same RIM. From there data can be accessed uniformly, e.g. as needed by Dräger´s decision support system SmartCare [2] for automated control and optimization of weaning from mechanical ventilation.
Why Is Clinical Information Not Reused?
Authors: Galster Gert
Published: February 2025

Reuse of clinical information plays a key role in the vision of a health sector with comprehensive semantic and pragmatic interoperability. Several papers have dealt with the secondary reuse of information, e.g. for statistics or research, while the primary reuse - clinical information reused in a clinical setting - has received less attention. On the basis of a qualitative literature review, this paper creates a categorised overview of the different causes to refrain from reuse of clinical information in clinical settings. The categorisation contributes to a greater understanding of failing reuse of clinical information in clinical settings, and it can probably be used in designing, evaluating and optimising clinical information systems. Further, it is speculated that the categorisation can be used in the process of identifying the concepts that constitute the context of clinical information.
Standardized EHR Interoperability – Preliminary Results of a German Pilot Project using the Archetype Methodology
Authors: Veseli Hasan  , Kopanitsa Georgy  , Demski Hans
Published: February 2025

The mobility of doctors and patients asks for multilingualism of electronic health record (EHR) systems: Doctors might face language problems using foreign medical information systems; people working abroad ask for continuous care which requires the treating physician to consult and understand the patient's health record. To address these linguistic and interoperability issues a solution is being developed that is based on widely acclaimed standards. Medical concepts that are derived from ASTM CCR define an interface model (based on ISO 13606). A server manages the data exchange between heterogeneous systems based on the interface model. It provides web services (automatic) and web forms (manual) and performs a transformation from the legacy scheme to the common structure. Furthermore, the server provides rich visualization capabilities (e.g. language-switch, custom charts etc.) which are useful for those EHR systems that don't provide these features.
Relevance of drug-drug Interaction in the ICU – Perceptions of Intensivists and Pharmacists
Authors: Askari Marjan  , Eslami Saied  , Louws Mathijs  , Dongelmans Dave  , Wierenga Peter  , Kuiper Rob  , Abu-Hanna Ameen
Published: February 2025

Relevancy of potential drug-drug interactions (pDDIs) is crucial in alerting system design. However, the way this relevancy is perceived is not well understood. The main objective of this study was to gauge and identify differences in perceptions of intensivists and pharmacists about pDDI relevancy in the ICU. Interactions were defined according to the national medication database using a computerized algorithm. Intensivists and pharmacists filled in a questionnaire to score their perceptions on relevancy of encountered pDDIs types. We conducted a focus group session to discuss pDDIs receiving markedly different relevancy scores. The questionnaire addressed 53 pDDI types. Pharmacists rated 29 pDDI types (54.7%) in the broad category “relevant” versus 16 (30.2%) for intensivists (p-value<0.001). The pharmacists and intensivists gave the same scores for 23 pDDI types (12 as relevant, and 11 as not relevant), and scored 30 types differently. The focus group discussion resulted in a total of 36 relevant and 17 not relevant types. Compared to the pharmacists in this panel, the intensivists were less inclined to consider a pDDI type as relevant. It is important to tailor medication databases with information about evidence and severity of pDDIs to the environment in which they are used.
Mapping SNOMED CT to ICD-10
Authors: Giannangelo Kathy  , Millar Jane
Published: February 2025

A collaboration between the International Health Terminology Standards Development Organisation (IHTSDO®) and the World Health Organization (WHO) has resulted in a priority set of cross maps from SNOMED CT®to ICD-10®to support the epidemiological, statistical and administrative reporting needs of the IHTSDO member countries, WHO Collaborating Centres, and other interested parties. Overseen by the Joint Advisory Group (JAG), approximately 20,000 SNOMED CT concepts have been mapped to ICD-10 using a stand-alone mapping tool. The IHTSDO Map Special Interest Group (MapSIG) developed the mapping heuristics and established the validation process in conjunction with the JAG. Mapping team personnel were selected and then required to participate in a training session using the heuristics and tool. Quality metrics were used to assess the training program. An independent validation of cross map content was conducted under the supervision of the American Health Information Management Association. Lessons learned are being incorporated into the plans to complete the mapping of the remaining SNOMED CT concepts to ICD-10.
Teaching Medicine with a Terminology/Ontology Portal
Authors: Grosjean Julien  , Merabti Tayeb  , Griffon Nicolas  , Dahamna Badisse  , Darmoni Stéfan J.
Published: February 2025

The Health Terminology/Ontology Portal (HeTOP) was developed to provide easy access to health terminologies and ontologie. The repository is not only dedicated to professionals but is also a valuable teaching tool. Currently, it provides access to thirty two health terminologies and ontologies available mainly in French or in English, but also in German, Italian, Chinese, etc. HeTOP can be used by both humans and computers via Web services. To integrate new resources into HeTOP, three steps are necessary: (1) designing a meta-model into which each terminology (or ontology) can be integrated, (2) developing a process to include terminologies into HeTOP, (3) building and integrating existing and new inter & intra-terminology semantic harmonization into HeTOP. Currently, 600 unique machines use the MeSH version of HeTOP every day and restricted terminologies/ontologies are used for teaching purposes in several medical schools in France. The multilingual version of HeTOP is available (URL: http://hetop.eu/) and provides free access to ICD10 and FMA in ten languages. Conclusion: HeTOP is a rich tool, useful for a wide range of applications and users, especially in education and resource indexing but also in information retrieval or performing audits in terminology management.
Towards a mLearning Training Solution to the Adoption of a CPOE system
Authors: Pakonstantinou Despoina  , Poulymenopoulou Mikaela  , Malamateniou Flora  , Vassilacopoulos George
Published: February 2025

Computerized Physician Order Entry (CPOE) has been introduced as a solution that can fundamentally change the way healthcare is provided, affecting all types of healthcare stakeholders and improving healthcare decisions, patient outcomes, patient safety and efficiency. However, a relatively small proportion of healthcare organizations have implemented CPOE systems, due to its technological complexity and to its low acceptance rate by healthcare professionals who largely disregard the value of CPOE in efficient healthcare delivery. An online training facility embedded within a CPOE service may increase the likelihood of its adoption by healthcare professionals as it offers them guidelines on how to perform each task of the CPOE service. In contrast to CPOE, on the other hand, handheld devices and other mobile technologies have showed an increased adoption rate. This paper considers a CPOE service that can be accessed by authorized healthcare professionals through their mobile devices anytime anywhere, and allows embedded training content, which has been developed through a learning management system (LMS) to be presented to the user automatically upon request.
Tackling Sensitive Issues Using a Game-based Environment: Serious Game for Relationships and Sex Education (RSE)
Authors: Brown Katherine  , Arnab Sylvester  , Bayley Julie  , Newby Katie  , Joshi Puja  , Judd Becky  , Baxter Alison  , Clarke Samatha
Published: February 2025

Experiencing sexual coercion during adolescence can lead to adverse psychological and physical health outcomes for those affected. Eliminatingsuch experiences is important for enhancingadolescent wellbeing, and the provision of good quality relationships and sex education (RSE) is needed. Engaging young people in sensitive subjectmatters in RSE can be challenging, and using Serious Gaming technology may support young people and educators in this process. This paper describes the use of Intervention mapping (IM) in the development of a serious game on the topic of sexual coercion for use in RSE. IM is a process that draws on stakeholder engagement and the theory and evidence base to support health improvement intervention planning. Serious game developers transformed the game concept ‘flat plan’ into an interactive gameshow. The game is teacher ledand aims to engage students in gameplay and discussion around the issue of sexual coercion. The final product known as PR:EPARe (Positive Relationships: Eliminating Coercion and Pressure in Adolescent Relationships) is the subject of an ongoing cluster Randomised Controlled Trial (RCT) in local schools. Early data analysis shows improvements in psychological preparedness for dealing with sexual coercion against some change objectives. This work represents the first attempt to use IM in the development of a Serious Game and the use of Serious Gaming for RSE delivery. RCT work is ongoing and PR:EPARe will become part of local RSE delivery in the new school year. Plans for ensuring broader impact of the game are in development.
Automatic Mechanisms for Measuring Subjective Unit of Discomfort
Authors: Hartanto Dwi  , Kang Ni  , Brinkman Willem-Paul  , Kampmann Isabel L.  , Morina Nexhmedin  , Emmelkamp Paul G.M.  , Neerincx Mark A.
Published: February 2025

Current practice in Virtual Reality Exposure Therapy (VRET) is that therapists ask patients about their anxiety level by means of the Subjective Unit of Discomfort (SUD) scale. With an aim of developing a home-based VRET system, this measurement ideally should be done using speech technology. In a VRET system for social phobia with scripted avatar-patient dialogues, the timing of asking patients to give their SUD score becomes relevant. This study examined three timing mechanisms: (1) dialogue dependent (i.e. naturally in the flow of the dialogue); (2) speech dependent (i.e. when both patient and avatar are silent); and (3) context independent (i.e. randomly). Results of an experiment with non-patients (n = 24) showed a significant effect for the timing mechanisms on the perceived dialogue flow, user preference, reported presence and user dialog replies. Overall, dialogue dependent timing mechanism seems superior followed by the speech dependent and context independent timing mechanism.
Reliability and Validity of TIPS Wireless ECG Prototypes
Authors: Rodríguez Alejandro  , Guixeres Jaime  , Rey Beatriz  , Alcañiz Mariano
Published: February 2025

The aims of the present study are to examine the reliability and validity of the Heart Rate signal registered using two self-made wireless ECG systems, R-Tips and TipsShirt, and to compare them with another commercial ECG device typically used in psychophysiology studies. An ECG simulator was used to artificially generate signals corresponding to different cardiac frequencies. Results of the reliability study showed that the signal acquisition, signal processing and signal transmission were reliable and valid for R-Tips and TipsShirt. Consequently, these wireless ECG prototypes could be used for studies where the freedom of movements of the participants is fundamental without any loss of quality in the registered signals.
In situ testing in soil dynamics
Authors: Kirichek Y.
Published: February 2025

The aim of this paper is to give a brief overview of same field measuring techniques of soil properties under dynamic loading. Evaluation of determination of spring and dumper properties of dynamically loaded soil are presented. The methods of measuring basic parameters such as the spring constant and damping coefficient are given. The responses of the single mass system, supported by a linear spring and a viscous damper are investigated for vertical, sliding, rocking, and torsion vibrations. Dynamic plate loading tests are used for measuring soil properties in a wide range of independent variety of magnitudes of static and dynamic loads. Influences of static and dynamic loads on spring and damping behavior of soil are studied at the building site of Uglegorsk thermal power plant. For soil behavior of the embedded foundations the methods of analysis have been developed. The field method for determining properties of embedded plates under dynamic loads has performed on the sites with loam and sand. Free vertical and horizontal vibrations of the plates induced by the proper impact of mass. Experimental results of the dumping ratio and mass ratios measuring have shown.
Decision Support for Evidence-Based Pharmacotherapy Detects Adherence Problems but Does Not Impact Medication Use
Authors: Willis Janese M.  , Edwards Rex  , Anstrom Kevin J.  , Johnson Fred S.  , Del Fiol Guilherme  , Kawamoto Kensaku  , Lapointe Nancy M. Allen  , Eisenstein Eric L.  , Lobach David F.
Published: February 2025

Although evidence-based pharmacotherapies are a principal component of patient care, 30–50% of patients do not take their medications as prescribed. We conducted a randomized trial of two clinical decision support (CDS) interventions in 2219 patients: patient adherence reports to providers (n=744), patient adherence reports to providers + email notices to care managers (n=736), and controls (739). At 18-month follow-up, there were no treatment-related differences in patient medication adherence (overall, by medication class, and by medical condition). There also were no treatment-related differences in patient clinical and economic outcomes. Thus, while this study's CDS information interventions were successfully delivered to providers and care managers, and were effective in identifying medication adherence deficits and in increasing care manager responses to medication adherences issues, these interventions were not able to alter patient medication behavior.
Applying the Clinical Adoption Framework to Evaluate the Impact of an Ambulatory Electronic Medical Record
Authors: Lau Francis  , Partridge Colin  , Randhawa Gurprit  , Bowen Mike
Published: February 2025

This paper describes the application of the Clinical Adoption (CA) Framework to evaluate the impact of a recently deployed electronic medical record (EMR) in a Canadian healthcare organization. The CA Framework dimensions evaluated were EMR quality, use and net benefits at the micro level; and people, organization and implementation at the meso level. The study involved clinical and support staff from two ambulatory care clinics, and managers and technical staff from the organization. A number of issues were identified at both levels of the CA Framework that had affected EMR adoption in the two clinics. Some perceived benefits in care coordination and efficiency were reported despite challenges that arose from early deployment decisions. There were five lessons that could be applied to other ambulatory care settings. The CA Framework has proved useful in making sense of ways that EMR can add value to the organization.
Commercial versus In-Situ Usability Testing of Healthcare Information Systems: Towards “Public” Usability Testing in Healthcare Organizations
Authors: Kushniruk Andre W.  , Borycki Elizabeth M.  , Kannry Joseph
Published: February 2025

The need for improved usability in healthcare IT has been widely recognized. In addition, methods from usability engineering, including usability testing and usability inspection have received greater attention. Many vendors of healthcare software are now employing usability testing methods in the design and development of their products. However, despite this, the usability of healthcare IT is still considered to be problematic and many healthcare organizations that have purchased systems that have been tested at vendor testing sites are still reporting a range of usability and safety issues. In this paper we explore the distinction between commercial usability testing (conducted at centralized vendor usability laboratories and limited beta test sites) and usability testing that is carried out locally within healthcare organizations that have purchased vendor systems and products (i.e. public “in-situ” usability testing). In this paper it will be argued that both types of testing (i.e. commercial vendor-based testing) and in-situ testing are needed to ensure system usability and safety.
A Model of Collaborative Agency and Common Ground
Authors: Kuziemsky Craig E.  , Cornett Janet Alexandra
Published: February 2025

As more healthcare delivery is provided via collaborative means there is a need to understand how to design information and communication technologies (ICTs) to support collaboration. Existing research has largely focused on individual aspects of ICT usage and not how they can support the coordination of collaborative activities. In order to understand how we can design ICTs to support collaboration we need to understand how agents, technologies, information and processes integrate while providing collaborative care delivery. Co-agency and common ground have both provided insight about the integration of different entities as part of collaboration practices. However there is still a lack of understanding about how to coordinate the integration of agents, processes and technologies to support collaboration. This paper combines co-agency and common ground to develop a model of collaborative agency and specific categories of common ground to facilitate its coordination.
3D Measuring Tool for Estimating Femoroacetabular Impingement
Authors: Hughes Chris J.  , John Nigel W.
Published: February 2025

Osteoarthritis of the hip is commonly caused by the repetitive contact between abnormal skeletal prominences between the anterosuperior femoral head-neck junction and the rim of the acetabular socket. Current methods for estimating femoroacetabular impingement by analyzing the sphericity of the femoral head require manual measurements which are both inaccurate and open to interpretation. In this research we provide a prototype software tool for improving this estimation.
A Set of Mixed–Elements Patterns for Domain Boundary Approximation in Hexahedral Meshes
Authors: Lobos Claudio
Published: February 2025

Hexahedral meshes are largely used by the Finite Element Method in a high variety of simulation problems. One of the most common problems of these type of meshes is to achieve an adequate approximation of curved domains; a feature typically found in the shape of organs. This work introduces a set of mixed-elements patterns, which are employed at the surface of target domain, and allow to conserve hexahedra elsewhere. These patterns are meant to be combined with any meshing technique producing a regular or non-regular hexahedral mesh.
A Haptic Simulator to Increase Laparoscopic Force Application Sensitivity
Authors: Long Lindsay O.  , Singapogu Ravikiran B.  , Arcese Giovannina  , Smith Dane E.  , Burg Timothy C.  , Pagano Christopher C.  , Burg Karen J.L.
Published: February 2025

Laparoscopic surgery demands perceptual-motor skills that are fundamentally different from open surgery, and laparoscopists must be adept at perceiving tissue interaction at the surgical site and then applying precise amounts of forces through instruments without damaging tissues. A haptic simulator that emulates multiple salient laparoscopic tasks and renders differing degrees of forces was created. Two of the haptic skills tasks were evaluated in two studies to determine their ability to distinguish and then train laparoscopic force application sensitivity. Results suggested that the simulator has the capability of rendering salient force feedback information to which novices become increasingly more perceptually sensitive.