bluuebunny/crossref_metadata_2025 huggingface dataset:
Complete title: Value of a secretomic approach for distinguishing patients with COVID-19 viral pneumonia among patients with respiratory distress admitted to intensive care unit Shortened title: Secretomic to distinguish COVID-19 patients
Authors: Blangy-Letheule Angélique , Vergnaud Amandine , Dupas Thomas , Habert Damien , Montnach Jérôme , Oulehri Walid , Hassoun Dorian , Denis Manon , Lecomte Jules , Persello Antoine , Roquilly Antoine , Courty José , Seve Michel , Leroux Aurélia A. , Rozec Bertrand , Bourgoin-Voillard Sandrine , Waard Michel De , Lauzier Benjamin
Published: October 2023

Introduction: In intensive care units, COVID-19 viral
pneumonia patients (VPP) present symptoms similar to those of other
patients with non-viral infection (NV-ICU). To better manage VPP, it is
therefore interesting to better understand the molecular pathophysiology
of viral pneumonia and to search for biomarkers that may clarify the
diagnosis. The secretome being a set of proteins secreted by cells in
response to stimuli represents an opportunity to discover new
biomarkers. Aims: Identify secretomic signatures of VPP
with those NV-ICU. Methods: Plasma samples and clinical
data from NV-ICU (n=104), VPP (n=30) or healthy donors (HD, n=20) were
collected at Nantes Hospital (France) upon admission. Samples were
enriched for the low-abundant proteins and analyzed using non-target
mass spectrometry. Specifically deregulated proteins (DEP) in VPP
versus NV-ICU were selected. Combinations of 2 to 4 DEPs were
established. Results: The differences in secretome
profiles of the VPP and NV-ICU groups were highlighted. Forty-one DEPs
were specifically identified in VPP compared to NV-ICU. Five
combinations of 3 proteins with a receiver operating characteristic
curve presenting an area under the curve of 95.0% were identified.
Conclusion: This study identifies five combinations of candidate
biomarkers in VPP compared to NV-ICU that may help distinguish the
underlying causal molecular alterations.
Suicidal Behavior in major affective disorders and their relationships with severity of depressive symptoms, inflammation, and childhood maltreatment
Authors: Nunes Sandra Odebrecht Vargas , Bellinello Gisele de Souza Teixeira , Urbano Mariana , Vargas Heber Odebrecht , Verri Waldiceu , Roussanais Ana Car olina
Published: October 2023

Background: The aim of this study was to investigate whether
individuals with and without a history of lifetime suicide attempts had
differences in more severe depressive, anxious, and manic symptoms,
functional impairment, quality of life, and childhood maltreatment,
besides cytokines Method: The cross-sectional study enrolled 54
suicide attempters and 154 non-suicide attempters. All individuals were
assessed through a questionnaire, structured clinical interview (SCID)
for diagnoses of major affective disorders, and scales (17 item-Hamilton
Depression Rating Scale, Young Mania Rating Scale, Hamilton Anxiety
Rating Scale, Sheehan Disability Scale, Childhood Trauma Questionnaire
and Quality of life). We also assessed anthropometric measures and
laboratory biomarkers .Results: Individuals with
history of lifetime suicide attempts showed significantly positive
correlations regarding soluble tumor necrosis factor receptor 1
(sTNF–RI) and severity of depressive symptoms (p= 0.013); interleukin-1
receptor antagonist (IL-1RA) and severity of depressive symptoms (p=
0.04); absenteeism from work and childhood physical abuse (p= 0.012).
Suicide attempters presented higher levels of interleukins (IL-13,
IL-5), interferon-gamma (IFNγ), granulocyte-macrophage
colony-stimulating factor (GM-CSF), and lower IL-4 levels.
Conclusions: The data suggest that a subgroup of patients with
history of lifetime suicide attempts in major affective disorders was
associated with childhood maltreatment and pro- and anti-inflammatory
cytokines.
Emerging Role of Protein Tyrosine Phosphatases in Cancer Therapy Resistance
Authors: Min Zhao , Wen Shuai , Zehao Su , Aoxue Wang , Guan Wang , Ouyang Liang
Published: October 2023

Tyrosine phosphorylation of intracellular proteins is a kind of
post-translational modification that regulates the signal transduction
in cellular process. The dephosphorylation of protein tyrosine
phosphatases (PTPs) on signal transduction proteins contributed their
role as a convergent node to mediate cross-talk between signaling
pathways. In cancer, PTPs-mediated pathways served as signaling hubs
through which cancer cells alleviated stress following the clinical
therapy, via promoting constitutive activation of growth-stimulatory
signaling pathways or influencing the immune-suppressive tumor
microenvironment. Preclinical evidences suggested that anticancer drugs
will release their greatest therapeutic potency when combined with PTP
inhibitors, reversing drug resistance that was responsible for clinical
failures during cancer therapy. Here, this review elaborated recent
insights that substantiated the role of PTPs-mediated pathways in
resistance to targeted cancer therapy and immune-checkpoint therapy,
leading to the proposal of targeting PTPs inhibition in anticancer
combination therapy for long-term disease regression. Clinical trials
have been initiated to evaluate the safety and efficacy of combination
therapy in advanced-stage tumors.
Innovations in the Care of chILD Associated with Connective Tissue Disease and Immune Mediated Disorders
Authors: Samad Aaida , Wobma Holly , Casey Alicia
Published: October 2023

Childhood interstitial lung disease associated with connective tissue
disease and immune mediated is the second most common chILD diagnostic
category. As knowledge of the molecular and genetic underpinnings of
these rare disorders advances, the recognized clinical spectrum of
pulmonary manifestations that can be associated with them continues to
broaden. This review will focus on chILD and other pulmonary
complications associated with primary immune disorders, namely monogenic
inborn errors of immunity as well as acquired systemic autoimmune and
autoinflammatory diseases. Pulmonary complications, including ILD in
these diseases can confer increased risk for morbidity and mortality and
can be complex to manage due to the multiple organ systems that can be
impacted in these systemic disorders. Thankfully, pulmonologists do not
have to work alone. These diseases often have stereotypical patterns of
extra-pulmonary features which aid in their recognition. In
collaboration with a multidisciplinary team of subspecialists, the
pulmonary and other systemic manifestations can be managed effectively
together. The goal of this review is to familiarize the reader with the
distinct patterns of ILD and associated systemic/immunologic features
that are characteristic of monogenic inborn errors of immunity and
systemic autoimmune and autoinflammatory diseases. In addition, this
review will highlight current, emergent and innovative therapeutic
strategies and will underscore the important role of multidisciplinary
management to improving outcomes for these patients.
Pore structure in detritusphere of soils under switchgrass and restored prairie vegetation community
Authors: Lee Jin Ho , Lucas Maik , Guber Andrey K. , Kravchenko AN
Published: October 2023

Root detritusphere, i.e., the soil in vicinity of decomposing root
residues, plays an important role in soil microbial activity and C
sequestration. Pore structure (size distributions and connectivity of
soil pores) in the detritusphere serves as a major driver for these
processes and, in turn, is influenced by physical characteristics of
both soil and roots. This study compared pore structure characteristics
in root detritusphere of soils of contrasting texture and mineralogy
subjected to >6 years of contrasting vegetation:
monoculture switchgrass and polyculture prairie systems. Soil samples
were collected from five experimental sites in the US Midwest
representing three soil types. Soil texture and mineralogy were measured
using hydrometer and X-ray powder diffraction, respectively. The intact
cores were scanned with X-ray computed micro-tomography to identify
visible soil pores, biopores, and particulate organic matter (POM). We
specifically focused on pore structure within the detritusphere around
the POM of root origin. Results showed that detritusphere of
coarser-textured soils, characterized by high sand and quartz contents,
had lower porosity in the vicinity of POM compared to finer-textured
soils. POM vicinities in finer soils had high proportions of large
(>300 μm Ø) pores, and their pores were better connected
than in coarser soils. Lower porosity in outer (>1 mm)
parts of detritusphere of switchgrass than of prairie suggested soil
compaction by roots, and the effect especially pronounced in coarser
soils. The results demonstrated that soil texture and mineralogy played
a major, while vegetation a more modest, role in defining the pore
structure in root detritusphere.
Low-intensity urbanisation alters community composition across multiple trophic levels on Lipsi Island, Greece
Authors: Hawkins Eleanor , Macrina Laura , Malcom-McKay Alice , Miliou Anastasia , Cotterill Nicola , O'Gorman Eoin
Published: October 2023

Urbanisation has reduced the abundance and diversity of many taxonomic
groups, and the effects may be more pronounced on islands, which have a
smaller regional species pool to compensate. Green spaces within urban
environments may help to safeguard wildlife assemblages, and the
associated habitat heterogeneity can even increase species diversity.
Here, total abundance and species diversity of butterflies, birds, and
vegetation at nine rural and nine urban locations were quantified on
Lipsi Island, Greece. Sites were assessed using Pollard walks for
butterflies, point-count surveys for birds, and quadrats for vegetation.
There was no significant difference in the abundance or species
diversity of butterflies or vegetation among rural and urban locations,
which could pertain to the low building density within urbanised areas
and the minimal extent of urbanisation on the island. However, urban
areas hosted a significantly greater abundance and richness of birds
compared to rural sites. The community composition of butterflies,
birds, and vegetation also differed significantly between urban and
rural locations, highlighting the impact of urbanisation on species
across a broad range of trophic groups. This study contributes to
ecological knowledge on the impacts of urbanisation across multiple
trophic levels in island ecosystems, with comparisons across a gradient
of island size and urbanisation intensity needed in future research.
The development, use, and challenges of electromechanical tissue stimulation systems
Authors: KANG Young-Bok (Abraham) , Hu Jie , Anderson William , Hayes Emily , Strauss Ellie Annah , Lang Jordan , Bacos Josh , Simacek Noah , Gibson Levi , McCarty Owen J.T.
Published: October 2023

Tissues including lung, heart, and bone in the body are subjected to
biological, electrical, and mechanical stimulations. These stimulations
greatly affect their growth, phenotype, and function, and play an
important role in modeling tissue physiology. With the goal of
understanding the molecular mechanisms underlying the response of
tissues to external stimulations, in vitro models of tissue
stimulation have been developed with the hopes of recapitulating
in vivo tissue function. Herein we review the efforts to create
and validate tissue stimulators responsive to electrical or mechanical
stimulation including tensile, compression, torsion, and shear. These
bioengineered platforms have designed such that tissues can be subjected
to select types of mechanical stimulation from simple uniaxial to
humanoid robotic stain through complex equal-biaxial strain. Electrical
stimulators have been developed to subject tissues to select electrical
signal shapes, amplitudes, and loading cycles were used in tissue
development derived from stem cell, maturation of tissue, and
regeneration of tissue function. Some stimulators allow for the
observation of tissue morphology in real-time while cells undergo
stimulation. We also discuss the limitations and challenges in the
development of tissue simulators. Despite advances in creating useful
tissue stimulators, there remain opportunities for improvements to
recreate physiological functions including: replicating complex loading
cycles, electrical and mechanical induction combined with biological
stimulation, and taking into account the change of strain affected by
the applied inputs. We expect that the use of tissue simulator platforms
will play an increasingly vital role in tissue modeling, stem cell
development, and drug development.
Deep learning solution of optimal reinsurance-investment strategies with extra information and multiple risks
Authors: Peng Fanyi , Yan Ming , Zhang Shuhua
Published: October 2023

This paper investigates an optimal investment-reinsurance problem for an
insurer who possesses extra information regarding the future
realizations of the claim process and risky asset process. The insurer
sells insurance contracts, has access to proportional reinsurance
business, and invests in a financial market consisting of three assets:
one risk-free asset, one bond and one stock. Here, the nominal interest
rate is characterized by the Vasicek model; and the stock price is
driven by the Heston’s stochastic volatility model. Applying the
enlargement of filtration techniques, we establish the optimal control
problem in which an insurer maximizes the expected power utility of the
terminal wealth. By using the dynamic programming principle, the problem
can be changed to four-dimensional Hamilton-Jacobi-Bellman equation. In
addition, we adopt a deep neural network method by which the partial
differential equation is converted to two backward stochastic
differential equations and solved by a stochastic gradient descent-type
optimization procedure. Numerical results obtained using TensorFlow in
Python and the economic behavior of the approximate optimal strategy and
the approximate optimal utility of the insurer are analyzed.
Predicting alpha amylase content and starch breakdown in pregerminated barley seeds using hyperspectral imaging
Authors: Propst Kevin , Hall Evan , Hirsch Cory D , Walling Jason G
Published: October 2023

Malting is the process of controlled germination of cereal grain that is
steeped, germinated, and dry kilned to develop flavor compounds,
fermentable sugars, the hydrolytic enzymes necessary for the brewing
process. To meet the strict standards of the brewing industry, variation
in the germination of barley grains need to be minimal but also maintain
rapid germination and optimum levels of α and
β amylase. Preharvest sprouting poses a signinicant
threat to barley cultivars prior to harvest, resulting in premature
endosperm modification, reduced enzyme content, and poor malthouse
pertormance. Pregerminated grain is ditticult to detect as there are
often no signs of damage, and current methods such as the Hagberg
falling/Stirring number, or pearling tests, each of which ultimately
leads to the destruction of the seed. Here we used time-series
hyperspectral imaging of barley seeds undergoing active and or
pregerminated seed and used a deep neural network to predict stirring
number and alpha amylase values, which are proxy measures for sprout
damage. Prediction models were made for seven genotypes tested
individually and with all genotypes combined. Stirring number assays
ranged from 0 to 190 and our prediction models had mean average errors
of 10.5 to 23.9 depending on the model. To increase the resolution and
accuracy of the predictions we transitioned from using bulk conventional
molecular assays to single seed assays and prediction models. These
results demonstrate that hyperspectral imaging and machine learning
models can be used to predict germinated grain in bulk and single seed
assays.
Digital phenotyping of Wheat (Triticum aestivum L.) canopy architectural and stomatal traits for drought and heat tolerance
Authors: Manawasinghe Kalhari , Tanino Karen
Published: October 2023

Wheat (Triticum aestivum L.) is one of the key staple crops
worldwide. Even though future demand for wheat is estimated to increase
by 6% by 2050, wheat production might drop by 30% due to climate
change. The purpose of this research is to identify canopy architecture
(light capture) and anatomical (stomatal) traits that significantly
increase radiation use efficiency (RUE; dry weight biomass produced per
unit radiation intercepted) and improve yield under high temperature and
drought stress conditions due to the growing concern over food security.
This research was conducted with five contrasting wheat genotypes in a
new field-based high tunnel system with 4 treatments and three
replications (control, heat stress, drought stress and heat x drought
stress with 3 replications = 12 tunnels) in a randomized completed block
design with stress applied at the heading stage. Canopy architecture was
graded according to the visual scoring scale concerning UPOV and RUE was
calculated in three growth stages. New techniques of high throughput
imaging of stomatal number and size using a handheld digital microscope
will also be presented.
The shape and volume of air, kernels, and cracks, in a nutshell
Authors: Amézquita Erik , Quigley Michelle , Brown Pat , Chitwood Daniel H. , Munch Elizabeth
Published: October 2023

Walnuts are the second most produced and consumed tree nut, with over
2.6 million metric tons produced in the 2022-23 harvest cycle alone. The
United States is the second largest producer, accounting for 25% of the
total global supply. Nonetheless, producers face an ever-growing demand
in a more uncertain climate landscape, which requires effective and
efficient walnut selection and breeding of new cultivars with increased
kernel content and easy-to-open shells. Past and current efforts select
for these traits using hand-held calipers and eye-based evaluations. Yet
there is plenty of morphology that meets the eye but goes unmeasured,
such as the volume of inner air or the convexity of the kernel. Here, we
study the shape of walnut fruits based on X-ray CT (Computed Tomography)
3D reconstructions. We compute 49 different morphological phenotypes for
1264 individuals comprising 149 accessions. These phenotypes are
complemented by traits of breeding interest such as ease of kernel
removal and kernel weight. Through allometric relationships —relative
growth of one tissue to another—, we identify possible biophysical
constraints at play during development. We explore multiple correlations
between all morphological and commercial traits, and identify which
morphological traits can explain the most variability of commercial
traits. We show that using only volume and thickness-based traits,
especially inner air content, we can successfully encode several of the
commercial traits.
Simulation and Optimization of Maize Phyllotaxy and Planting Pattern to Intercept More Radiation
Authors: Xiang Zhaocheng , Ge Yufeng
Published: October 2023

Maximizing crop yield while conserving resources is a pressing challenge
in modern agriculture. Maize (Zea mays L. ), a staple crop
worldwide, relies heavily on photosynthesis, making radiation
interception a pivotal factor in crop growth and yield. This study
presents a novel approach to improve maize crop productivity by
harnessing the principles of phyllotaxy and optimizing planting patterns
to efficiently intercept solar radiation. Through the enhanced 3D maize
model generation algorithm, the simulation incorporates critical factors
such as curved surface leaf area, leaf arrangement, plant spacing, and
solar angles, allowing us to quantify the radiation intercepted by the
maize canopy. We investigate the most efficient phyllotaxy for
individual plants and evaluate a range of planting patterns and their
impact on radiation interception at various growth stages. Simulation
results reveal that optimizing planting patterns based on phyllotactic
principles can substantially enhance radiation capture compared to
traditional planting methods. In conclusion, our research signifies a
significant step towards harnessing the power of plant arrangement and
optimizing planting strategies, including the use of an enhanced 3D
maize model, to maximize radiation interception in maize crops. The
optimal phyllotaxis and planting patterns establish a distinct
phenological target for breeders. These findings hold promise for the
development of more resilient and productive agricultural systems in an
era of growing global food demand and resource constraints.
Impact of Guideline-Directed Statin Intervention for Primary Prevention in Patients With Diabetes
Authors: Muluk Pallavi , Zhu Jianhui , Thoma Floyd , Hay Eli , Marroquin Oscar , Makani Amber , Aiyer Aryan , Nasir Khurram , Gulati Martha , Shapiro Michael D. , Mulukutla Suresh , Saeed Anum
Published: October 2023

OBJECTIVE

We examined guideline-directed statin intensity (GDSI) use and atherosclerotic cardiovascular disease (ASCVD) outcomes in patients with diabetes across a contemporary health care system.

RESEARCH DESIGN AND METHODS

Patients without preexisting ASCVD were categorized by diabetes status and 10-year ASCVD risk (borderline [5–7.4%], intermediate [7.5–19.9%], high [≥20%]). Mean ±SD time to start of or change to GDSI was calculated. Incident ASCVD and all-cause mortality association, stratified by ASCVD risk, was calculated using Cox regression.

RESULTS

Among 282,298 patients, 28,807 (10.2%) had diabetes and 253,491 (89.8%) did not. Only two-thirds of intermediate- and high-risk patients with diabetes were receiving GDSI therapy at 5-year follow-up. In fully adjusted models, patients with diabetes not taking a statin (vs. GDSI) had a significantly higher risk of stroke and mortality in the intermediate- and high-risk groups (hazard ratio for mortality 1.81 [95% CI 1.58–2.07] vs. 1.41 [1.26–1.57]; P for interaction < 0.01).

CONCLUSIONS

Significant gaps remain in GDSI use for high-risk patients with diabetes, conferring an increased risk of ASCVD outcomes and all-cause mortality.
Association Between Atrial Fibrillation and Diabetes-Related Complications: A Nationwide Cohort Study
Authors: Kwon Soonil , Lee So-Ryoung , Choi Eue-Keun , Ahn Hyo-Jeong , Lee Seung-Woo , Jung Jin-Hyung , Han Kyung-Do , Oh Seil , Lip Gregory Y.H.
Published: October 2023

OBJECTIVE

This study aimed to investigate the associations between concurrent atrial fibrillation and diabetes-related complications among patients with diabetes.

RESEARCH DESIGN AND METHODS

This nationwide observational cohort study used the health checkup database from the Korean National Health Insurance Service. Patients diagnosed with diabetes who underwent health checkups between 2009 and 2012 were investigated. The patients with atrial fibrillation were matched in a 1:5 ratio with those without atrial fibrillation using propensity scores. Study outcomes included macrovascular, microvascular (diabetic retinopathy and diabetic nephropathy), and diabetic foot complications. The risks of clinical outcomes were measured using hazard ratios (HRs) with 95% CIs.

RESULTS

A total of 65,760 patients with diabetes were analyzed (54,800 without atrial fibrillation and 10,960 with atrial fibrillation). After well-balanced propensity score matching, atrial fibrillation was associated with significantly higher risks of macrovascular complications (HR 1.12, 95% CI 1.09–1.16), diabetic nephropathy (HR 1.23, 95% CI 1.16–1.30), and diabetic foot complications (HR 1.13, 95% CI 1.09–1.17) compared with no atrial fibrillation, while the risk of diabetic retinopathy was comparable (HR 0.99, 95% CI 0.96–1.03). Patients with atrial fibrillation had a significantly higher risk of diabetic foot amputation (HR 4.12, 95% CI 1.98–8.56).

CONCLUSIONS

Among patients with diabetes, concurrent atrial fibrillation was associated with increased risks for diabetes-related macrovascular complications, diabetic nephropathy, and diabetic foot. Such patients require holistic management to reduce the risk of adverse outcomes.
COVID-19 Vaccination Prior to SARS-CoV-2 Infection Reduced Risk of Subsequent Diabetes Mellitus: A Real-World Investigation Using U.S. Electronic Health Records
Authors: Yi Jin Hsieh Tina , Chang Renin , Yong Su-Boon , Liao Pei-Lun , Hung Yao-Min , Wei James Cheng-Chung
Published: October 2023

Background Previous studies have indicated a bidirectional correlation between diabetes and SARS-CoV-2 infection. However, no investigation has comprehensively explored the potential of COVID-19 vaccination in reducing the risk of new-onset diabetes mellitus (DM) in infected individuals. Methods In the first cohort, we compared the risk of new-onset DM between 1,562,606 SARS-CoV-2 infected individuals and non-infected individuals using the TrinetX database to validate findings in prior literature. For the second cohort, we identified 83,829 vaccinated and 83,829 unvaccinated COVID-19 survivors from the same period. DM, anti-hyperglycemic drug use, and composite of both were defined as outcomes. We conducted Cox proportional hazard regression analysis for the estimation of hazard ratios (HRs) and 95% confidence intervals (CI). Kaplan-Meier analysis was conducted to calculate the incidence of new-onset DM. Subgroup analyses based on age (18-44, 45-64, 65), sex (female, male), race (White, Black or African American, Asian), and BMI categories (<19.9, 20–29, 30–39, ≥40) , sensitivities analyses and a dose response analysis were conducted to validate the findings. Findings The initial cohort of patients infected with SARS-CoV-2 had a 65% increased risk (HR, 1.65; 95%CI, 1.62-1.68) of developing new-onset DM relative to non-infected individuals. In the second cohort, we observed that vaccinated patients were associated with a 21% lower risk of developing new-onset DM in comparison to unvaccinated COVID-19 survivors (HR, 0.79; 95% CI, 0.73-0.86). Subgroup analyses by gender, age, race, and BMI yielded similar results. These findings were consistent in sensitivity analyses and cross-validation with an independent dataset from TriNetX.
Suspected Accidental Infiltration of Rocuronium During General Anesthesia Induction: A Case Report
Authors: Sakurai Yuya , Shibuya Makiko , Okiji Ryuichi , Hase Yuri , Hojo Takayuki , Kimura Yukifumi , Fujisawa Toshiaki
Published: October 2023

There are few reports on rocuronium infiltration under general anesthesia. We report a case of suspected accidental rocuronium infiltration during anesthesia induction. A 25-year-old woman with autism spectrum disorder, intellectual disability, and epilepsy was scheduled for the extraction of 4 impacted third molars under general anesthesia. After induction with sevoflurane, an intravenous (IV) line was established in the left cephalic vein. Rocuronium was administered; however, subcutaneous swelling at the IV site was observed immediately. Spontaneous ventilations were maintained until additional rocuronium was administered via a new IV line. After heat pack application, the swelling disappeared 60 minutes after infiltration, and no tissue damage was observed. A strategy was developed to continue neuromuscular monitoring until recovery occurred. Acceleromyography was used, and the train-of-4 ratios at 99, 130, and 140 minutes after infiltration were 0.79, 0.91, and 1.0, respectively. Sugammadex was administered to prevent neuromuscular blockade recurrence. The patient was extubated once adequate return of muscle function and consciousness were observed. No neuromuscular block prolongation or recurrence were observed postoperatively. When rocuronium infiltration is suspected, it is important to eliminate swelling at the infiltration site and determine a management strategy based on neuromuscular monitoring.
Fiber laser cutting of steel plate by twin spot beam setting in scanning direction
Authors: Okamoto Yasuhiro , Morimoto Kota , Kai Naoki , Okada Akira , Ishiguro Hiroaki , Ito Ryohei , Okawa Hiroshi
Published: October 2023

This study investigated the effects of laser beam intensity distribution on the reduction of dross height in fiber laser cutting of a steel plate with 3.2 mm thickness. A twin-spot beam was produced by splitting a single Gaussian beam into two beams using a special axicon lens, and these beams were set in the scanning direction for cutting experiments. The power ratio of two beams (R:F = Rear power:Front power) was varied to discuss the intensity balance for the effective reduction of dross. After cutting experiments, ray tracing analysis was conducted using an optical analysis to calculate the absorbed power density distributions in the kerf. A smaller dross height of 18 μm can be achieved at a power ratio of R:F = 8:2, and its value is lower than that by a single Gaussian beam. At a power ratio of R:F = 8:2, the front beam of lower power is irradiated at the upper part of the workpiece, and the rear beam of higher power is absorbed at the lower part of the workpiece. Thus, effective heat input to the lower part of the workpiece can contribute to a reduction of the dross height. Variation of power ratio in the rear and the front beams is effective in controlling the cutting front shape, and the uniformity of absorbed power in the thickness direction can be improved by setting the rear beam of about four times higher power to the front beam of lower power to obtain a smaller dross height in the case of a 3.2 mm steel plate.
Data Resource Profile: COVid VAXines Effects on the Aged (COVVAXAGE)
Authors: Hayes Kaleen , Harris Daniel , Zullo Andrew , Djibo Djeneba Audrey , Smith-Ray Renae L. , Taitel Michael S. , Singh Tanya G. , McMahill-Walraven Cheryl , Chachlani Preeti , Wen Katherine , McCarthy Ellen P. , Gravenstein Stefan , McCurdy Sean , Baird Kristina E. , Moran Daniel , Fenson Derek , Deng Yalin , Mor Vincent
Published: October 2023

BackgroundTo improve the assessment of COVID-19 vaccine use, safety, and effectiveness in older adults and persons with complex multimorbidity, the COVid VAXines Effects on the Aged (COVVAXAGE) database was established by linking CVS Health and Walgreens pharmacy customers to Medicare claims.
MethodsWe deterministically linked CVS Health and Walgreens customers who had a pharmacy dispensation/encounter paid for by Medicare to Medicare enrollment and claims records. Linked data include U.S. Medicare claims, Medicare enrollment files, and community pharmacy records. The data currently span 01/01/2016 to 08/31/2022. "Research-ready" files were created, with weekly indicators for vaccinations, censoring, death, enrollment, demographics, and comorbidities. Data are updated quarterly.
ResultsAs of November 2022, records for 27,086,723 CVS Health and 23,510,025 Walgreens unique customer IDs were identified for potential linkage. Approximately 91% of customers were matched to a Medicare beneficiary ID (95% for those aged 65 years or older). In the final linked cohort, there were 38,250,873 unique beneficiaries representing ~60% of the Medicare population. Among those alive and enrolled in Medicare as of January 1, 2020 (n = 33,721,568; average age = 73 years, 74% White, 51% Medicare Fee-for-Service, and 11% dual-eligible for Medicaid), the average follow-up time was 130 weeks. The cohort contains 16,021,055 beneficiaries with evidence a first COVID-19 vaccine dose. Data are stored on the secure Medicare & Medicaid Resource Information Center Health & Aging Data Enclave.
Data accessInvestigators with funded or in-progress funding applications to the National Institute on Aging who are interested in learning more about the database should contact Dr Vincent Mor [Vincent_mor@brown.edu] and Dr Kaleen Hayes [kaley_hayes@brown.edu]. A data dictionary can be provided under reasonable request.
ConclusionsThe COVVAXAGE cohort is a large and diverse cohort that can be used for the ongoing evaluation of COVID-19 vaccine use and other research questions relevant to the Medicare population.
Correntes espirituais em diálogo:
Authors: Wolff Elias , Villa Forte Marcelo
Published: October 2023

O atual pluralismo religioso e espiritual apresenta sérios desafios para o encontro, o diálogo, a convivência e a cooperação entre as diferentes formas de crer.  Felizmente, caminhos são percorridos para superar esses desafios, envolvendo diferentes comunidades religiosas em projetos de cooperação social, o diálogo teológico, o cuidado da criação, entre outros. Neste artigo, mostramos que há um horizonte ou dimensão do diálogo inter-religioso que serve como sustento e impulso dos demais: a espiritualidade. Nossa tese propõe a convergência das espiritualidades como caminho para sustentar as iniciativas de diálogo e cooperação e superar os obstáculos que permanecem para um verdadeiro encontro entre as religiões. Apresentamos elementos que favorecem para essa convergência, como a compreensão da experiência espiritual, a meta e a mediação dessa experiência, e a afirmação da transcendência humana. A sintonia nesses elementos favorece para que as religiões superem tensões e conflitos que as impedem de assumir juntas o compromisso pela vida humana e da criação.
Arte, Poder e Resistência
Authors: Marques Miranda Filho Francisco
Published: October 2023

O período no qual se dá a formação inicial da identidade deuteronômica de Israel e de Judá se situa no contexto da construção da zona de poder do império neoassírio. A expansão imperial assíria incluiu a ocupação do norte do Levante, a dissolução do Reino de Israel, e a relação com o Reino de Judá na forma de reino cliente. Os assírios usaram diversas maneiras para expressar seu poder e estabeleceram um intercâmbio que aconteceu nos campos econômico, social e cultural. Entre as expressões de poder estão o uso de textos e da arte na construção das cidades centrais empreendidas por alguns dos principais reis neoassírios, mas também outros instrumentos de prestígio e favor aos designados pelo reino central para administrar os territórios conquistados que se tornaram províncias. É preciso avaliar o impacto da agenda imperial neoassíria na relação com os territórios conquistados e os satélites no Levante Sul, mas, principalmente, buscar entender as formas de resistência e como as mudanças ocorridas nesse período podem ser um dos elementos da formação de parte da identidade israelita presente nos textos do Livro do Deuteronômio.
Modeling of the modes of operation of wind energy installations in hybrid power supply systems
Authors:   Lviv Polytechnic National University, Lviv, Ukraine, Medykovskyy M. O. , Melnyk R. V. ,   Lviv Polytechnic National University, Lviv, Ukraine, Melnyk M. V. ,   Lviv Polytechnic National University, Lviv, Ukraine
Published: October 2023

The article presents modern schemes for the organization of wind-solar power supply systems. Available approaches to managing the energy-dynamic process of operation of wind power plants as part of hybrid power supply systems are given, and modern research on this topic is given. The results of the development of a mathematical model of the energy-dynamic processes of the hybrid wind-solar power supply system, which includes wind power plants, solar panels, and a battery energy storage system. The universal structural diagram of such a system is substantiated. A set of production rules for the implementation of management of the hybrid power supply system and a simulation model of energy-dynamic processes for possible modes of operation of the system have been developed. The simulation model was developed in the IntelliJ IDEA programming environment using the Java programming language, the Spring framework, and the PostgresDB relational database. A simulated simulation of the system's operation was carried out in order to determine the optimal operating modes depending on the restrictions on the number of switchings of each wind power plant, the structure of the system and the parameters of its elements. The input data for the study of operating modes are the wind energy potential, the solar energy potential at a given geographical point, the number and technical parameters of wind electric installations and solar panels, as well as the energy parameters of the storage element. In order to reduce the number of switching (switching on/exclusion) of wind electrical installations in the hybrid power supply system, the parameter "Minimum interval between consecutive changes in the active composition of the wind farm" was introduced. The result of simulation modelling is the establishment of the following dependencies: customer support time from the deficiency of power supply probability (DPSP); the minimum interval between determinations of the active set of the wind power plant based on the number of switchings; the minimum interval between determinations of the active composition of wind turbines from the average deviation of the generation capacity. The obtained results will make it possible to optimize the parameters and modes of operation of hybrid wind-solar systems, as well as algorithms for managing energy-dynamic modes in the design and operation of systems.
Perspectives of Islamic Education Students Regarding to Urgency of Technological Skills and Foreign Language Abilility
Authors: Wulandari Viona Dwi , Ramadhany Nur Fadilah , Lisa Mona , Neem Chuti , Sari Widia Wahana , Mathew Ingrid Brita Deborah
Published: October 2023

This study aims to analyze the perceptions of students majoring in Islamic religious education towards technological skills and mastery of foreign languages as prospective teachers. This study used a quantitative research method with a survey approach. Data sources were taken using a questionnaire to fifty student respondents as prospective Islamic religious education teachers from four different universities on the island of Sumatra. All were then analyzed descriptively using SPSS software version 20. The results of the analysis showed that; i) in general, respondents agree that technology is a very effective medium in supporting the learning process, in fact, students as prospective teachers must master technology that can be integrated with learning. ii) further related to mastery of foreign languages, as a whole the respondents agreed that mastery of foreign languages for students majoring in teacher training can support their careers as professional teachers, besides that foreign languages are a tool for finding various sources as learning materials so teachers can be creative and innovate in learning process. The findings are initial information for future researchers in studying this problem in more or less the same context and issues
Student Assessment of the Personality Competence and Social Competence of Islamic Religious Education Teachers
Authors: Yaumas Nova Erlina , Yemmardotillah Yemmardotillah , Sari Mukhtia , Nisa Fadhila Khairatun , Mulyawati Husni , Nasir Ainul Athirah Binti Abdull
Published: October 2023

Personality and social competencies are two out of four competencies that should be possessed by those who teach Islam education. The two competencies are not merely observed and assessed when teachers are in classe or school environment, but also in their domicile surroundings. The study is aimed at analyzing learners’ assessment on their teachers’ personality and social competencies. The study employs quantitative method through survey approach. Data are collected by likert scale questionnaires of fifteen questions related to the competencies which spreaded to three hundred eighty-two students of distinctive High Schools in Indonesia. The respondents are selected through the method of total random sampling. All data are descriptively analyzed by a software of SPSS version 26. The findings of the study reveal that the personality and social competencies of Islamic religious education teachers are satisfactory. Thus, the findings object the prior studies that shows the two competencies of islamic religious education teachers are low. Finally, the findings can be an initial idea for more advanced study related to teachers’ competencies in different contexts and levels.
The Relation between Self-Regulation, Self-Efficacy and Achievement Motivation among Muslim Students in Senior High Schools
Authors: Sabrina Rifdah , Risnawati Risnawati , Anwar Khairil , Hulawa Djeprin E. , Sabti Fajri , Rijan Mohd Hakim Bin Mothar , Kakoh Nur Asikin
Published: October 2023

This research was conducted to analyze the relationship between self-regulation and self-efficacy in the context of achievement motivation among Muslim Senior High School students in Indonesia. A quantitative correlational method was used, and data sources were collected through a questionnaire with a four to five-point Likert scale. A total of 565 respondents, drawn from a population pool of 1,568, were selected using a simple random sampling technique. Furthermore, data were analyzed through bivariate and multivariate correlation techniques using SPSS Version 20 software. The results showed that, first, there was a significant positive correlation between self-regulation and achievement motivation of students. Second, a positive correlation of statistical significance was evident between self-efficacy and achievement motivation. Third, a strong and significant positive correlation was reported when simultaneously considering self-regulation and self-efficacy. This research served as evidence of self-regulation and self-efficacy in shaping academic performance of students during the academic pursuits. Therefore, the two variables should be accorded significant attention and concern by stakeholders, with a particular emphasis on teachers and parents.
The Urgency of Linguistic Skills to Read Kitab Tafsir in Boarding Schools in Indonesia: Analysis of Students’ Learning Issue
Authors: Namira Silva , Wiza Rahmi , Huda Binti Mohd Nadhir Nazratul , Alhabib Alhabib
Published: October 2023

The study is aimed at investigating learners’ issues on reading kitab tafsir in boarding schools in Indonesia. This study employs the case study approach of the qualitative method. Data is collected through in-depth interviews with ten informants (teachers and learners) selected by using purposive sampling technique. The data is thematically analyzed by using interactive analysis technique of Miles & Huberman model of NVivo 12. The findings of the study reveal that there are nineteen learners’ linguistic issues to understand the kitab tafsir. All issues are grouped into four categories, namely: two issues are related to ashwat (phonology), six issues are connected to sharaf (morphology), six issues are about nahwu (syntax), and other five issues are related to dilalah (semantic). All issues revealed in the study are crucial to be solved to understand the kitab tafsir in boarding schools all over Indonesia. Thus, teachers should be creative to find interesting and innovative learning techniques so that reading the kitab tafsir is no longer an issue for learners. The nineteen issues are deeply and comprehensively analyzed and discussed in the article.
Divorce of Intoxicated Persons in the Islamic Jurisprudence and Afghan Civil Law: An Inductive and Analytical Juridical Study
Authors: Poya Aminullah , Ghalia Bouhedda , Hamat Mohd Afandi Bin Awang
Published: October 2023

The phenomenon of divorce in the context of intoxication has drawn limited scholarly attention, necessitating an exploration of its legal implications and theoretical underpinnings. This study employs an inductive and analytical approach, structured into an introduction, three main sections, and a conclusion that encompasses the research findings. The study synthesizes primary legal sources from Islamic jurisprudence, including the Quran and Hadith, alongside relevant provisions of the Afghan Civil Code and pertinent case law. Through a comprehensive examination of Islamic principles and legal precedents, the research delves into the multifaceted issue of divorce within the context of intoxication, addressing pertinent questions regarding the legal capacity and consent of an intoxicated individual to initiate or accept divorce. The analysis also investigates the rights and protections afforded to both parties in such circumstances, considering the overarching objectives of Islamic family law. The study highlights the varying approaches between Islamic jurisprudence and Afghan civil law, identifying potential areas of harmonization or conflict. Drawing on case examples and hypothetical scenarios, the paper further contextualizes the theoretical findings and proposes possible legal reforms to address the complexities arising from the divorce of intoxicated individuals. Ultimately, this research contributes to a deeper understanding of Islamic family law and its application in Afghanistan, while shedding light on the challenges posed by intoxication in the divorce context. The findings of this study may inform legal practitioners, policymakers, and scholars seeking to promote justice, equity, and protection within the realm of family law in both Islamic and Afghan legal systems.
Asymmetry and convergence in the development of digital technologies in the EU countries
Authors: Kolupaieva Irina , Tiesheva Larysa
Published: October 2023

Research background: Digitalization in the context of the COVID-19 pandemic has accelerated significantly across Europe, including in regions that are at the stage of catch-up development. However, as innovative technologies are intensively integrated into everyday life, the digital gap between the EU countries is increasing. The widening digital gap is becoming a serious threat to achieving the EU's sustainable development goals and building a sustainable European society.
Purpose of the article: The purpose of the article was to empirically substantiate the inclusiveness and convergence of the digital strategy in the EU countries.
Methods: Using the method of fuzzy sets, the level of asymmetry in access to transactional            (e-commerce), information (cloud computing), operational (artificial intelligence) technologies in the EU countries was assessed. The negative impact of the digital gap within the countries (the gap between small, medium, large companies) and the global digital gap (the gap between EU countries) on the competitiveness of countries was established, for which correlation analysis and the Granger causality test were used.
Findings & value added: The findings of this study contribute to the literature of digital transformation and digital gap of European countries. The impact of the digital gap in transactional, information, operational technologies on the competitiveness of countries is differentiated depending on the level of digitalization of the country. Cluster groups of countries are determined by the convergence of digitalization and ways to ensure long-term competitiveness. The directions for reducing the digital gap in the EU countries are substantiated by changing the priorities of spending on innovation and increasing productivity, diversifying the digital technologies used. The empirical results obtained can serve as a basis for improving the effectiveness of the digitalization policy in the EU countries in accordance with individual convergence goals. The main added value of the paper is related to the presented research procedure, which can be used in analyses of digital technologies development also for other countries. The results provide valuable insights into evaluating the digital technologies in European countries.