bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Multifunctional Phenanthroline-Derived Probe for Colorimetric Sensing of Fe2+ and Fluorometric Sensing of Zn2+
Authors: Qi Chen-Yu , Dong Xue , Fan Ying-Cui , Yuan Jun-Ru , Song Zi-Jie , Zhang Yong-Han , Xie Ya-Ping , Yang Feng , Ma Jian-Ping , Wang Meng , Qin Jie
Published: June 2024

A new phenanthroline derivative bearing imidazole group, (2-(3,5-di(pyridin-4-yl)phenyl)-1-p-tolyl-1H-imidazo[4,5-f][1,10]phenanthroline) has been devised. The derivative serves as a multifunctional probe, exhibiting a highly sensitive colorimetric response to Fe2+ ion and a selectively ratiometric fluorescent response to Zn2+ ion in a buffer-ethanol solution. The colorless-to-red visual color change upon addition of Fe2+ accompanied by enhanced absorption makes this derivative a suitable naked-eye sensor for Fe2+ ion. Moreover, the derivative displayed a Zn2+-induced red-shift of emission (44 nm), showing a color change from blue to light cyan under a 365-nm UV lamp. Its practical imaging applicability for intracellular Zn2+ was confirmed in HeLa cells using a confocal microscope. The improved emission properties and cell imaging capability would provide a new approach to fluorescence sensation for Zn2+.
Automated eDNA Extraction from Estuarine Samples Using Magnetic Beads v1
Authors: El Baidouri Fouad , Kelly Muriel , Watts Alison
Published: June 2024

This method presents an optimized protocol for the automated extraction of environmental DNA (eDNA) from estuarine samples using magnetic beads. The addition of Proteinase K to the lysis solution facilitates DNA solubilization at 56°C and mechanical rotation ensures thorough lysis. The DNA is then purified using a double ethanol wash and magnetic bead-based extraction on a KingFisher system. The method is designed for filters preserved in Longmire's buffer. If a different preservation is used the first step should be modified.
RT-QuIC Assay for the Detection of Chronic Wasting Disease in Rectal Mucosa of White-Tailed Deer v1
Authors: B. Piel Robert , A. Schneider David , E. Veneziano Susan
Published: June 2024

This protocol details a Real-Time Quaking-Induced Conversion (RT-QuIC) assay to detect the prion-seeding activity associated with Chronic Wasting Disease prions in rectal mucosa samples from white-tailed deer. The authors tested this protocol as part of an agreement between USDA-APHIS, USDA-ARS, and USGS.
THE NEXT EXACERBATION OF THE RUSSIAN-UKRAINIAN CONFLICT: THE RISK OF A FULL-SCALE WAR
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Raikov A.
Published: June 2024

The next exacerbation of the Russian-Ukrainian armed conflict taking place at the end of 2021 is considered, and its impact on bilateral relations between the United States of America and the Russian Federation as the main geopolitical actors in the region is analysed. The stages of the onset of the current exacerbation and the reaction of official Washington and Moscow to the current situation are also described.
FUNDING FOR SCIENCE AND RESEARCH ABROAD: EXPERIENCE FOR UKRAINE
Authors:   Institute for Economics and Forecasting, National Academy of Sciences, Ukraine, Sidenko S.
Published: June 2024

The article analyses the problems of promoting innovation in different countries under conditions of information society. It is the innovation process, which involves intelligence, experience, knowledge, and values, that allows many countries to benefit from these advantages and achieve high rankings in global competition. As innovation becomes a powerful driver of economic growth and international competitiveness, national governments pay special attention to the challenges of scientific and technological development by focusing financial, intellectual and research resources on these targets. To ensure the innovative development, different countries of the world mobilize domestic resources – financial, human, intellectual, and creative capital, business potential, and attract external factors – international scientific and technical cooperation, international alliances, multinational corporations, global value chains and others. The conditions of global competition produce changes in the set of factors that support innovative growth and competitiveness of nations in the world markets. Proper funding of research and development becomes one of the most important factors among them. These problems are especially relevant for Ukraine, as the innovative development model might drive the country to a new technological level, support sustainable economic growth and competitive position in the global innovation market, as well as create new jobs in new science-intensive industries, which boost employment and prosperity.
FLORA OF VASCULAR PLANTS OF NATIONAL NATURE PARK "ZALISSIA"(KYIV AND CHERNIHIV REGIONS)
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kolomiichuk Vitalii , Shynder Olexandr ,   M. M. Gryshko National Botanical Garden, NAS of Ukraine, Kyiv, Baranskyi Olexandr ,   M. M. Gryshko National Botanical Garden, NAS of Ukraine, Kyiv, Shevera Myroslav ,   M. G. Kholodny Institute of Botany, NAS of Ukraine, Kyiv
Published: June 2024

Background. The aim of our study is to establish the current species composition of the flora of vascular plants of the National Nature Park "Zalissia" (Kyiv and Chernihiv regions, Ukraine), its analysis and identification of regional peculiarity. Methods. Research methods are classical comparative floristic, which are used for vegetation research during field trip, and its further cameral processing as well as critical analysis of the literature and herbarium data. Scientific novelty is at first on the territory of the Park, which had been closed for a long time to such research, complexes floristic inventarization studies were conducted. Results. The results of the study was analyzed and for the first time integral data on the structure of the flora were obtained. The taxonomic composition of the flora of the Park has been established (778 species and subspecies of vascular plants), which is more than half (58.5 %) of the diversity of the regional flora of Eastern Polissia. The results of the fractional and structural analysis of the flora of the Park are presented. The flora is consists of 612 native and 166 alien taxa. Systematic, life form and geographical analysis of the flora was carried out, and its peculiarities were identified. The native and alien fractions of the Park's flora were analyzed. The structural features of the native fraction of the flora reflect its rather well-defined forest character. In the family spectrum, the highest positions belong to Asteraceae, Poaceae and Rosaceae. The hemicryptophytes (65.7 %) predominate in life form spectra, and the total share of woody plants is 11.6 %. Widespread taxa are dominated, but a high share of Boreal, European, and European-sub-Mediterranean geoelements. Conclusions. The results of the fractional analysis indicate that the adventitization process dominates the synanthropization of the flora. The taxa of sub-Mediterranean origin are dominated in alien fraction flora, and American and Asian origin species have the largest number.
Deafness, Kinship, and Formal Possibility in Bollywood
Authors: Kantor Roanne L.
Published: June 2024

This article focuses on two films in popular Hindi cinema (Bollywood) – Koshish and Barfi! – that put Deaf protagonists at the center of romantic comedies. It moves beyond typical studies of disability as a device of characterization and locates meaning instead in under-analyzed elements of filmic production. These include sound production, plot structure, and their unique entanglement in Bollywood through the picturized song-sequence. Songs pose a special challenge for stories about Deaf protagonists, one which Koshish treats as a problem requiring "accommodation," and Barfi addresses as an opportunity for "Deaf gain." At a deeper level, Bollywood "provincializes" some key assumptions within the primarily Eurocentric field of disability studies and its frequent association with another Eurocentric field, queer theory. While crip theory follows queer theory's opposition to the "reproductive" time of conjugality, this stance flattens differences between the two communities, and depends on a misunderstanding of what "reproduction" entails. Bollywood romantic comedies, by contrast, create a space to rethink disabled kinmaking. Here the films are reversed: Koshish, though older, offers a more radical negotiation of social reproduction, while Barfi! is somewhat more conventional in its imagined future for disabled families.
Fathers' Relationships with Their Disabled Children: A Literature Review
Authors: Davies Alison , Rix Jonathan , Robb Martin
Published: June 2024

Fathers' relationships with their disabled children is a neglected topic in the academic literature. This article is the first review of studies in the field, comprising a comprehensive overview of research published since 1980. Forty-five studies met the inclusion criteria. Although fathers emphasise positive aspects of their relationships, existing research foregrounds more negative aspects. These studies tend to identify five themes that signal positive father-child relationships. These themes are: an evolving relationship; caregiving practices; relational aspects of caregiving; recognising and supporting their children's agency; and (inter)connectedness. While fathers' relationships with their disabled children is an under-researched topic, the existing literature on the topic focuses on the negative impact of having a disabled child. Understanding the complexity and rewarding aspects of fathers' engagement warrants further research.
Students’ Intention to Learn and Academic Performance in the Blended Learning Environment: The Role of Artificial Intelligence Chatbots
Authors:   St. Petersburg Peter the Great Polytechnic university, Saint-Petersburg, Russia, Aleksandra Kobicheva
Published: June 2024

In the era of universal digitalization, new technologies and services are being created, among which we can highlight the development of chatbot technologies that can be effectively used in the educational process and that will be of interest to representatives of the younger generations. The current study aims to reveal the influence of artificial intelligence chatbot integration on students’ intention to learn and their academic performance in the blended learning environment. The research framework includes 7 key indicators: Satisfaction (SAT), Perceived Usefulness (PU), Attitude (ATD), Subjective Norms (SN), and Perceived Behavioral Control (PBC), Continuance Intention to Learn (CIL) and academic performance (AP), which are evaluated in traditional blended learning setting (N=104) and blended learning based on artificial intelligence chatbot (N=107). For comparison we used the average scores, standard deviations (σ) of students on 23 items and student’s t-test for independent samples. We also calculated Pearson correlation coefficient for all analyzed. The results of the current study confirmed the positive influence of artificial intelligence usage during the blended learning as it increases students’ attitude, satisfaction and perceived usefulness which directly and highly affects the intention to continue learning and academic performance.
Development of Organoids from Malignant Ascites for Cancer Research in Oman
Authors: Khan Fazal , Yaqoob Nausheen , AlYahyaee Aida H , AlZadjali Shoaib A , Burney Ikram A
Published: June 2024

NONE
Prioritizing Bridges for Seismic Resilience Enhancement: A Case Study of Algeria
Authors: Abdellaoui Mohammed , Badaoui Mohamed , Bensaibi Mahmoud , Koriga Said
Published: June 2024

Algeria is located in an active seismic zone, making its bridges vulnerable to damage, especially older ones. Due to the importance of bridges in terms of safety, social, and economic factors, competent authorities must prepare for disasters, particularly earthquakes, by enhancing bridge resilience. However, due to the large number of bridges and lack of funding, it is not feasible to improve all bridges at once. This article proposes a model to determine priorities for enhancing bridge resilience to earthquakes based on expert opinions in three main steps. Step 1: Identification of key criteria, where design phase, bridge health, seismic zone, bridge importance, availability of alternative roads, and disaster insurance are defined as key criteria. Step 2: Calculation of criteria weights using the analytic hierarchy process (AHP) and integration of expert opinions using the Euclidean distance-based aggregation method (EDBAM). Step 3: Calculation of the priority index after evaluating criteria categories. The model was applied to six bridges, and their ranking was established based on the priority index. The model has proven its accuracy and ability to assist decision-makers in identifying priority bridges.
Injustiça ambiental e suas vozes: uma discussão a partir da visão pluralista de Judith Shklar sobre a injustiça
Authors: Gardelin Lucas Dagostini , Dalsotto Lucas Mateus
Published: June 2024

O presente trabalho, de cunho qualitativo e bibliográfico, pretende investigar de que modo injustiça e vulnerabilidade ambientais se relacionam na sociedade contemporânea e qual o papel que a justiça ambiental deve desempenhar no combate de suas causas e efeitos. A visão pluralista de Judith Shklar, em especial a apresentada em sua obra The Faces of Injustice (1990), pode oferecer valiosas contribuições para uma leitura do fenômeno da injustiça e da vulnerabilidade ambientais numa chave jurídico-filosófica. A primeira seção apresenta algumas das principais linhas teóricas presentes no campo da justiça ambiental, traçando um quadro panorâmico de suas características, diferenças e influências. A segunda seção, por sua vez, explora as relações existentes entre vulnerabilidade e injustiça ambiental, caracterizando tais fenômenos e a natureza variável dos liames entre eles existentes. A terceira seção discute a temática a partir do pensamento de Judith Shklar, especialmente no que diz respeito à injustiça, suas formas de manifestação e à necessidade de uma resposta democrática. Por fim, a última seção analisa os desastres ambientais de Mariana e Brumadinho à luz das reflexões shklarianas sobre injustiça. A tese de fundo dessa investigação é de que a manifestação pública do sentimento de injustiça, a denúncia do sofrimento e a contestação dos padrões que naturalizam ou invisibilizam injustiças são a própria razão da política democrática e, argumenta-se, de uma verdadeiramente política ambiental.
Submissões a periódicos e reação a incentivos
Authors: Steinmetz Wilson Antônio , Tramontina Robison
Published: June 2024

Editorial
ÇOCUKLARA YÖNELİK YOUTUBE VİDEOLARININ ÇOCUĞUN CİNSEL İSTİSMARI AÇISINDAN DEĞERLENDİRİLMESİ
Authors: Tosun Ece
Published: June 2024

ÖZ
Yeni iletişim teknolojilerinin gelişmesi sosyal paylaşım platformlarına duyulan ilgiyi arttırmıştır. Bu platformlarda yer alan içeriklerin henüz bilişsel gelişimini tamamlamamış çocuklar tarafından büyük ölçüde denetimsiz kullanılıyor olması olası tehlikeleri de beraberinde getirmektedir. Bu tehlikelerden biri, bugün Türkiye’nin en fazla kullanılan sosyal paylaşım platformu olan YouTube’da çocuğa yönelik hazırlanan ve izlenme sayısı milyonlara ulaşan animasyon videolarının çocuğun cinsel istismarını normalleştiren içerikler barındırmasıdır. Geçmişten bugüne çocuklara yönelik cinsel istismar olaylarının yaşandığı ve yaşanmaya devam ettiği günümüz dünyasında çocukların bu istismarı normalleştiren, psikososyal gelişimlerini olumsuz etkileyecek içerikler ile karşılaşmaları üzerine düşünülmesi ve çalışmalar yapılması gereken önemli bir konudur. Bu doğrultuda çalışmanın amacı, YouTube’ta yer alan çocuklara yönelik animasyon videolarını çocuğun cinsel istismarı açısından incelemek ve bu istismarın çeşitleri üzerinden analiz etmektir. Çalışmada, YouTube videolarının niteliği, niceliği ve içerik üretme pratikleri incelenmiştir. Araştırma sonucunda; incelenen animasyon videolarının %30’unun ensest, %60’ının pedofili, %40’ının erken evlilik, %20’sinin ise erken hamilelik barındırdığı, video kapak görsellerinin %40’ı, video isimlerinin ise %100’ünün çocuğa yönelik cinsel istismar içeren görsel/söz barındırdığı sonuçlarına ulaşılmıştır. Ayrıca videolarda yetişkin dünyasına ait sözlerin kullanılması ve yetişkinler tarafından yaşanan istismarın onaylanması dikkat çekmektedir. Çocukların psikososyal gelişimine zarar verebilecek, çocuğun cinsel istismarını normalleştiren sosyal medya videoları üzerine literatürde çalışmaların kısıtlı olması bu çalışmayı özgün kılmaktadır.
SAĞLIK İLETİŞİMİ: SAĞLIK KURULUŞLARININ SAĞLIĞIN TEŞVİKİ VE GELİŞTİRİLMESİ AMACIYLA TWİTTER KULLANIMI
Authors: Karataş Eren , Bayçu Sevil
Published: June 2024

Çalışmada sağlığın geliştirilmesi ve teşviki amacıyla sağlık iletişiminde sosyal medyanın rolü ve bir sosyal medya platformu olarak X (Twitter) tartışılmaktadır. Çalışmanın amacı sağlık kuruluşlarının X’i yapısal ve işlevsel olarak nasıl kullandığını incelemektir. Bu doğrultuda 18 Haziran 2022 – 18 Haziran 2023 tarihleri arasında “Türk Diyabet Vakfı, Türk Kanser Derneği ve Türk Kalp Vakfı” sağlık kuruluşlarının X hesapları içerik analizi yöntemi kullanılarak analiz edilmiştir. Çalışmada elde edilen bulgulara sağlık kuruluşları X’i yapısal özellikleri bakımından daha etkin bir şekilde kullanmaları gerektiği görülmektedir. Sağlık kuruluşlarının iletişim sürecinde ve mesaj tasarımında daha çok örgütsel konular ve kişisel sağlık konularıyla ilgili bilgilendirme eğiliminde oldukları görülürken, bir mesajın işlevi kullanıcılar tarafından beğenilme ve yeniden yayınlanma ihtimalini etkilemektedir.
THE EFFECT OF HEALTH EDUCATION REGARDING PREVENTION OF PULMONARY TUBERCULOSIS TRANSMISSION TO KNOWLEDGE AND ATTITUDES OF COMMUNITY
Authors: Khoirun Nisa Nurul , Siagian Basirum , Pratama Rika Yuanita , Sunarti Sunarti
Published: June 2024

Introduction: Tuberculosis (TB) is an infectious disease that is a major cause of poor health and one of the leading causes of death worldwide. Pulmonary tuberculosis or often referred to as pulmonary TB is an infectious disease that is still endemic in society. The purpose of this study was to determine the knowledge and attitudes of the community regarding preventing the transmission of pulmonary tuberculosis. Methods: This used a quantitative design with a pre-experimental approach, using a convenience sampling technique with a sample size of 40 respondents. The research was conducted at the Community of Nanga Pemubuh Village, Sekadau Regency. This research data collection used a questionnaire measuring instrument. The analysis used was a Paired Sample T-test and Wilcoxon test with a significance level of ɑ<0.05. The variables involved in this research were health education, knowledge, and attitudes. Results: The statistical test results were obtained at knowledge p value = 0.004 and attitude p value = 0.013, meaning that statistically health education had a significant effect on increasing community knowledge and attitudes before and after education about preventing the transmission of tuberculosis in Nanga Pemuhuh Village, Sekadau. Conclusions: Health education regarding preventing the transmission of pulmonary tuberculosis has a significant effect on increasing public knowledge and attitudes. Increasing knowledge and attitudes about preventing the transmission of tuberculosis after outreach is expected to be able to reduce the prevalence rate of tuberculosis.
THE RELATIONSHIP BETWEEN ANXIETY WITH QUALITY OF LIFE ELDERLY SUFFERING FROM HYPERTENSION AT PUSKESMAS BABADAN PONOROGO
Authors: Iswatun Iswatun , Lutfiandini Cherlys Tin , Wijayanti Endah Sri , Umam Khotibul , Sairozi Ali , Susanto Joko , Rindayati Rindayati
Published: June 2024

Introduction: quality of life is a person's perception of the physical, psychological, social, and environmental conditions in life. Quality of life is impacted by excessive anxiety about health conditions one of them hypertension. The creasing of age and hypertension experienced elderly trigger other diseases. This study aims to determine the relationship between anxiety and quality of life in elderly people with hypertension. Methods: The research design uses quantitative with a cross-sectional study. The inclusion criteria were elderly people with high blood pressure ≥140/90 mmHg. Sampling was carried out using a purposive sampling technique, totaling 160 samples. The instruments used were the GAI and OPQOL-BRIEF questionnaires. Statistical test with Spearman Rank (Rho). Results: For more than half of the total sample, elderly anxiety was in the moderate category (63.1%) and most of the elderly's quality of life was in the poor category (80.8%). The statistical test results showed a significance of 0,000 because ρ < 0.05, it was concluded that there was a significant relationship between anxiety and quality of life in elderly people with hypertension at Puskesmas Babadan Ponorogo. The closeness is relationship 0.699 considered strong. Conclusions: There is a relationship between anxiety and quality of life in elderly people with hypertension at Puskesmas Babadan Ponorogo. It is hoped that respondents can improve their healthy lifestyle, have regular health check-ups, and not feel excessively anxious about their health
Potential of chitosan and activated carbon biocomposites for removing enrofloxacin and oxytetracycline from water
Authors: Molina-Amaya José Manuel , Ávila-Reyes José Antonio , Delgado-Alvarado Eli Amanda , González-Valdez Laura Silvia , Torres-Ricario Rene , Rojas-López Marlon , Almaraz-Abarca Norma , Gutiérrez-Velázquez Marcela Verónica
Published: June 2024

Enrofloxacin (ENRO) and oxytetracycline (OTC) are two antibiotics, which are difficult to remove by conventional water treatment methods. The characteristics of the biocomposites suggest that they could represent an alternative for the removal of this type of substances through adsorption processes. The current study aimed to determine and compare the potential of biocomposites formed with chitosan and different concentrations of activated carbon (AC) with a particle size of 500 nm, prepared from agave bagasse, to remove enrofloxacin and oxytetracycline solved in water. The effectiveness of the addition of different concentrations of AC (0, 0.5, 2 and 5% w/v) to chitosan was evaluated by morphological analysis using scanning electron microscopy (SEM). The detection of the characteristic functional groups carried out by Fourier transform infrared spectroscopy (FTIR) indicated that the nanoparticles of AC were attached in the chitosan biocomposite, and stable chemical crosslinking was formed during the polymerization process. The removal test of ENRO (10 mg/mL) and OTC (10 mg/mL) in a water was performed by a gradient method of high-performance liquid chromatography (HPLC). The results showed that the addition of AC to chitosan formed a biocomposite with maximum capacity to remove 59.3% of OTC (contact time 2 h at 100 rpm, 4 g biocomposite/L solution, pH 6-7, 30 ºC), and a maximum removal of 50.3% of ENRO (contact time 2 h at 100 rpm, 4 g biocomposite/L solution, pH 6, 30 ºC). Biocomposites formed by chitosan and agave activated carbon can support the development of tools for the removal of recalcitrant antibiotics from water bodies.
Thermodynamic Energy Analysis of a Superconducting Shielding Magnetic Field Model
Authors: Zheng Yong gang
Published: June 2024

The Meissner effect is a special property of superconductors. In this paper, based on the characteristics of the Meissner effect, a superconducting phase transition model of a superconductor under a changing magnetic field is proposed. A thermodynamic analysis was performed on the model to calculate both the changes in the thermodynamic parameters of the superconductor during the phase transition and the changes in the overall work and energy of the model. For Model 1 in the present study, the thermodynamic energy of the superconductor was not conserved due to the phase change of the superconductor under a changing magnetic field.
Clinical Profiles in Autism Spectrum Disorder: Enhancing Diagnosis, Treatment, and Overall Health Outcomes
Authors: Machado Cruz Tielle
Published: June 2024

Autism Spectrum Disorder (ASD), a neurodevelopmental disorder, is increasingly diagnosed and significantly affects communication, behavior, and social interaction. The current diagnostic framework, guided by the DSM-5, has limitations that may lead to clinical gaps due to overlapping symptoms of ASD and other disorders. This study proposes a comprehensive approach to enhance ASD diagnosis through clinical stratification based on comorbidities. We applied precision medicine techniques to identify and categorize ASD into ten clinical profiles. Our findings contribute to a more profound understanding of ASD, including its varied clinical manifestations and comorbidities, and facilitate the development of personalized therapeutic strategies.
Noninvasive Estimation of Intracavitary Cardiac Pressures Using Speckle Tracking Echocardiography in Advanced Heart Failure
Authors: Martini Luca , Lisi Matteo , Pastore Maria Concetta , Righini Francesca Maria , Rubboli Andrea , Henein Michael  Y. , Cameli Matteo
Published: June 2024

Health care is currently showing a fall in heart failure (HF) prevalence and incidence particularly in developed countries, but with only a subset receiving appropriate therapy to protect the heart against maladaptive processes such as fibrosis and hypertrophy. Appropriate markers of advanced HF are still needed, which should help choosing the most suitable therapy and avoid major compliance problems. Speckle tracking echocardiography (STE) is a good choice, being a non-invasive imaging technique and is able to assess cardiac deformation in a variety of conditions. Several multicenter studies and meta-analyses have demonstrated its clinical applications and accuracy in early and late stages of HF, as well as its association with both left ventricular (LV) filling pressures and myocardial oxygen consumption, the two are important parameters in the evaluation of HF patients. Also, STE assists in assessing right ventricular free-wall longitudinal strain (RVFWLS) which is a solid predictor of right ventricle failure (RVF) following LV assist device (LVAD) implantation. Despite its limitations, STE plays an essential role in the clinical evaluation of patients with HF, early and advanced, in explaining symptoms and signs and also as an accurate prognosticator. The aim of this review is to examine the advantages of STE in early evaluation of myocardial dysfunction and their correlation with right heart catheterization (RHC) parameters, which should have a significant clinical relevance in the management of HF patients.
Prinsip Contra Proferentem pada Banker Clause (Studi Pada Putusan Pengadilan Tinggi Nomor 64/PDT/2016/ PT PAL)
Authors: Sasono Wasis Singgih , Isharyanto Isharyanto
Published: June 2024

Kegiatan kredit dan asuransi dalam kesepakatannya dituangkan dalam bentuk kontrak kredit dan polis asuransi. Dalam kontrak tersebut, pihak penyedia kredit sebagai pengusaha memasukkan klausula baku yang dituangkan dalam bentuk formulir yang akan disetujui atau tidak disetujui oleh calon nasabah (take it or leave it). Klausula baku kontrak kredit dalam bentuk banker clause mengharuskan nasabah menggunakan dan melunasi asuransi jiwa sebagai jaminan pertanggungan bilamana terjadi risiko di kemudian hari dalam masa pelunasan kredit. Penelitian ini bertujuan menganalisis prinsip contra proferentem yang digunakan pada putusan Pengadilan Tinggi Nomor 64/PDT/2016/PT PAL. Penelitian ini menggunakan metode penelitian hukum normatif (doctrinal research). Pendekatan dalam penelitian ini menggunakan pendekatan perundangan dan pendekatan konsep hukum berupa pelaksanaan prinsip contra preferentem pada banker clause. Bahwa pada contoh kasus pada putusan pengadilan tersebut, sebagai upaya terakhir, contra proferentem hanya relevan jika ada hasil imbang, yaitu sisi masing-masing menominasikan dua atau lebih yang sama-sama masuk akal, tetapi saling kontradiktif, interpretasi kontraktual mereka. Dalam kasus ini karena jelas posisi konsumen dilemahkan atas klausula baku yang dibuat pengusaha dalam hal ini perusahaan kredit perbankan dan asuransi yang mangkir dan seolah-olah itu menjadi konsekuensi kontrak bagi konsumen (nasabah). Pada contoh putusan pengadilan tingkat pertama telah menggunakan prinsip contra proferentem karena hal pelemahan konsumen dengan desakan somasi tanpa dasar yang faktual. Namun sangat disayangkan terjadi cacat formil, pihak asuransi PT Asuransi Bumi Asih Jaya belum dipanggil secara patut maka putusan dinyatakan batal demi hukum.
Kewajiban Hukum Perusahaan dalam Pelaksanaan CSR berdasarkan Peraturan Perundang-Undangan
Authors: Ady Narwan Theo Ady Theo
Published: June 2024

Pertumbuhan ekonomi yang menyebabkan permasalahan lingkungan dan sosial. Dengan adanya masalah tersebut, maka dikeluarkanlah Undang-Undang Nomor 40 Tahun 2007 tentang Perseroan Terbatas dan Undang-Undang Nomor 25 Tahun 2007 tentang Penanaman Modal dan Undang-Undang 19 Tahun 2003 tentang BUMN. Namun, Peraturan tersebut ada ketidaksinkronan yang mengakibatkan kebingungan dan menjadi celah bagi perusahaan untuk tidak melakukan kewajiban CSR. Penelitian ini bertujuan supaya Indonesia lebih mempertegas pengaturan mengenai kewajiban pelaksanaan CSR. Metode yang digunakan pada penelitian ini adalah Metode Yuridis Normatif dengan menggunakan pendekatan peraturan perundang-undangan (statute approach) dan perbandingan peraturan perundang-undangan (comparative approach). Hasil Penelitian pertama berisi mengenai ketidaksinkronan perundang-undangan yang diterapkan di Indonesia. Ketidaksinkronan peraturan CSR mengakibatkan munculnya peraturan dibawahnya yang lebih ditingkatkan; Perusahaan Swasta dan BUMN wajib menerapkan CSR yang sudah diatur oleh Undang-Undang Nomor 40 Tahun 2007 tentang Perseroan Terbatas dan Undang-Undang Nomor 25 Tahun 2007 tentang Penanaman Modal dan Undang-Undang 19 Tahun 2003 tentang BUMN, meskipun secara implisit UUPM dan UUPT tidak mengatur mengenai sanksi.
Management of Nasal Valve Dysfunction
Authors: Lee Dong-Yun , Won Tae-Bin
Published: June 2024

Nasal valve dysfunction can substantially impact nasal airflow and overall quality of life. This review provides a comprehensive examination of nasal valve dysfunction, including its mechanisms, classification, and surgical management. The nasal valves include internal and external valves, each of which plays a crucial role in regulating nasal airflow. Subclassification of the external nasal valve into alar and rim valves helps specify the site of obstruction when present and informs the choice of surgical intervention. Dynamic nasal valve obstruction, often characterized by inspiratory collapse of the nasal valve, must be distinguished from static obstruction, which refers to nasal valve stenosis. Accurate identification of the location and mechanism of nasal valve dysfunction is essential for effective management. Various surgical procedures target specific components of the nasal valve and can produce favorable functional outcomes. The selection of surgical procedures, whether individually or in combination, should be tailored to the characteristics of nasal valve dysfunction and the external nasal characteristics of the patient. Strict adherence to proper surgical techniques is imperative for achieving optimal treatment outcomes.
Prediction of the Optimal Post-Fracturing Soaking Time in Multifractured Shale Gas/Oil Formations on the Basis of Modeling of Fluid Imbibition
Authors: Guo Boyun , Mahmood Md Nahin , Wortman Philip B. , Nguyen Vu V.
Published: June 2024

Post-fracturing fluid soaking is believed to significantly affect productivity of hydraulic-fractured horizontal wells in the oil and gas industry. It is highly desirable to know the optimal soaking time period to maximize well productivity. An analytical model was developed in this research to describe the dynamic spontaneous imbibition process in shale cracks owing to fluid soaking. The model was integrated with pressure falloff data to develop a mathematical approach for forecasting the optimal soaking time, which is defined as the time it takes for the fluid to reach the midpoint between two adjacent hydraulic fractures. The optimal soaking time depends on crack and fluid properties, including crack width, fluid contact angle, and interfacial tension (IFT). A case study from the data of Tuscaloosa Marine Shale (TMS) suggests that the optimal soaking time is 2–4 weeks if the fracturing spacing is 4–6 m. This work provides petroleum engineers with a quick-and-easy method for predicting the optimal soaking time to maximize their well productivity.
Hybrid Feature Selection for Classification of Colon Cancer Using Data Processing by Support Vector Machines
Authors: Kumar V.T Ram Pavan , Ramesh P.L , Arulselvi M
Published: June 2024

Colon cancer is considered a dangerous disease in humans, and it is one of the main risks to human life. In spite of the advances in screening, analysis, and handling, colorectal cancer (CRC) or colon cancer is the major widespread and Third-leading cause globally. The precise prediction of cancer with the gene data is very important for diagnosing cancer. However, the enormous dimensions of the gene expression data make the cancer prediction approach more complex. This paper devises a novel Support Vector Machine (SVM) for the classification of colon cancer. Here, the input data are gathered from the dataset and is fed to the feature selection module for selecting the features. Here, the selection is made using the Entropy and the Bhattacharya distance measures separately in order to select the unique features. Once the features are selected developed SVM provide the final classified output. The proposed SVM classifier outperformed other techniques with a maximum accuracy of 97.38%, higher sensitivity of 97.61%, and maximum specificity of 96.77% in terms of training data.
A comparative study of statistical methods and machine learning algorithms for prediction of landslides in Mizoram state of India through analysis of causative factors using Geo-informatics
Authors: VANLALNUNZIRA JOEL TC , Prakash Satya
Published: June 2024

The landslide has been one of the most severe and significant natural hazards in the study area, Mizoram, which has rolling hills and deep valleys in almost every landform. A comparative study of landslide hazards in the area was conducted using various statistical analytic techniques and machine learning algorithms. The statistical method includes- Frequency Ratio (FR), Analytic Hierarchical Process (AHP), Shannon’s Entropy (SE), and Weight of Evidence (WOE), while the machine learning algorithms methods comprise basic classifiers such as Gradient Boosting Decision Tree (GBDT), Random Forest (RF), and Extreme Gradient Boosting (XGB), and hybrid classifiers using the Logistic Regression (LR) methods viz., GBDT + LR, RF + LR, XGB + LR. The study aims to find out the collinearity of various parameters of landslide-inducing factors and analyse their weight for most contributing factors to least contributing factors. It also aims to develop the Landslide Hazard Zonation (LHZ) map using various parameters weights and layer stacking by weighted sum overlay in a GIS software environment. The generated LHZ map was separated into five classes viz., low, moderate, high, very high, and severe. For statistical analysis, validation of the zonation maps was done by using past landslide inventories. Classification of the number of past landslides point data in each class of the zonation map was done to validate the accuracy of the zonation map. More than 65 per cent of Landslide point data falls in the High to Severe zone in the classification for FR, AHP, and SE which was considered to be in the positive validate zone, whereas only 60 per cent of Landslide point data falls in the High to Severe zone for WOE which was considered to be inadequate and undesirable for applicable LHZ map. For machine learning algorithms, a buffer zone of a 50m radius was created for the application of the seeding technique for preparing landslide inventory. More than 10000 landslide seeds cells and non-landslide cells were taken in which 80% and 20% train-test split was conducted. A series of metrics such as accuracy, precision, recall, f- f-measure, Area Under (receiver operating characteristic) Curve (AUC), kappa index, mean absolute error (MAE), and root mean square error (RMSE) was used to evaluate the accuracy and performance of the seven models. Based on the AUC curve, the XGB model having the highest AUC value (0.9039) was identified as the most efficient model among the machine learning models. It was found that an improvement of more than 15% accuracy was shown by the machine learning models compared to the statistical approach. The results suggest that the machine learning method is propitious for an application in landslide estimation in the study area.
Atypical case of pattern disruption in sex proportions of Tabanidae collections with malaise traps in ecuadorian forests
Authors: Buestan Jaime , Vera Gabriel A. Brito
Published: June 2024

Male horseflies have low capture rates in Malaise traps, a widely documented pattern observed in numerous ecological studies. We present findings from a specific locality in Ecuador where a departure from this established pattern is observed. In this locality, males accounted for 59.14% of Tabanidae captures. The disruption in capture patterns observed using Malaise traps represents an uncommon feature in the scientific literature and during collections conducted over eight years in Ecuador. Despite the inherent limitations of Malaise traps in capturing male horseflies, it is possible that under specific conditions, such as the presence of optimal aggregation areas for horseflies, Malaise traps may enhance the capture efficiency of males. Additionally, we provide a detailed discussion on the disruption and disparity in capture sex proportions in Tabanidae, commonly reported in the scientific literature. Understanding these aspects of tabanid behavior is essential due to the outbreaks and deaths associated with trypanosomiasis infections in Ecuador.
RNA Sequencing Analysis for the Identification of Genes Associated with Cisplatin Resistance in Ovarian Cancer
Authors: Wani Taha Umair , Kim Hyun-Yi , Lee Geum-Hwa , Lim Young Je , Chae Han-Jung , Kim Ji-Ye , Yoon Hyonok
Published: June 2024

Cisplatin is a drug of choice for the treatment of ovarian cancer (OC). However, the development of resistance to platinum-based drugs is common, causing relapse and complicating the clinical management of these patients. The identification of biomarkers of resistance can contribute to a better stratification of the patients for treatment strategies. This study compared the transcriptional profile of two cisplatin-resistant OC cell lines, OV90CisR1 and OV90CisR2, to their sensitive counterpart, OV90. R-tool was used for the screening of significant differentially expressed genes (DEGs, p ≤ 0.05), gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and protein-protein interaction (PPI) analyses. In the top-ranked GO terms, we found extracellular matrix (ECM) and actin filament-related pathways. Consequently, we observed a high expression of integrins (ITGA1, ITGA6, ITGA11, and ITGAV), collagen (COL3A1, COL4A1, COL7A1, COL11A1), fibronectin (FN1) and other related proteins in the PPI analysis. The analysis shows how these factors show alteration in ECM composition and reorganization of the actin cytoskeleton, further supported by the overexpression of metallopreoteases (ADAMTS2, ADAMTS7, ADAMTSL1, and ADAMTSL4) as evident in the PPI network. We conclude that these changes in ECM could stimulate integrins and facilitate epithelial to mesenchymal transition (EMT) through pathways like Wnt signaling. Transition to a mesenchymal phenotype can cause drastic changes in the membrane transport e.g., highly expressed ABC efflux transporters (ABCA5, ABCD2) in the present case, which can lead to drug resistance.
Analysis of clinical characteristics of severe mycoplasma pneumoniae pneumonia complicated with virus infection in children
Authors: Li Na , Qiang Guang feng , Liu Rui han , Meng Lan lan , Ning Jun , Shen Chang qing , Yu Guang zhi
Published: June 2024

Background
To summarize the pathogenesis and etiological characteristics of Severe Mycoplasma Pneumoniae Pneumonia (SMPP) with viral infection.
Methods
SMPP patients admitted to Affiliated Hospital of Jining Medical Universityfrom July 2021 to June 2022 requiring bronchoscopic alveolar lavage were retrospectively collected. Multiple reverse transcription polymerase chain reaction (mRT-PCR) was used to detect respiratory pathogens combined with serum mycoplasma antibody titer. The children were divided into Mycoplasma Pneumoniae (MP) infection group and MP mixed virus infection group according to whether they were infected with mixed virus or not. The differences of clinical manifestations, physical examination, laboratory examination, imaging data and bronchoscopy manifestations were analyzed.
Results
Among 784 children with SMPP, 425 were males (54.21%) and 359 were females (45.79%). The ratio of males to females was 1.18:1. Children over 5 years old were the high incidence group of SMPP. There were 638 cases of single MP infection (81.38%), 146 cases of co-infection (18.62%), and the top two cases of co-infection were adenovirus (ADV) in 74 cases (50.68%) and respiratory syncytial virus (RSV) in 67 cases (45.89%). Compared with the MP mixed virus infection group, there were statistically significant differences in age, season, hospital stay, fever time, lung consolidation and emphysema (P < 0.05), but no significant differences in other clinical manifestations, laboratory indicators and bronchoscopy (P > 0.05). Compared with MP mixed ADV group, there were significant differences in the level of lactate dehydrogenase and season (P < 0.05).
Conclusion
Adenovirus and respiratory syncytial virus are the most common co-infected viruses of SMPP. In terms of laboratory indexes and fiberoptic bronchoscopy, the disease characteristics of single MP infection group, mixed virus infection group, MP mixed ADV group and MP mixed RSV group were similar. The age of MP patients with virus infection was younger, the hospitalization time was longer, the fever time was longer, and the patients with emphysema were more. The level of lactate dehydrogenase in children with RSV infection was higher than that in patients with ADV infection.
Wolbachia infection in Aedes aegypti does not affect its vectorial capacity for Dirofilaria immitis
Authors: Shirozu Takahiro , Regilme Maria Angenica F , Ote Manabu , Sasaki Mizuki , Soga Akira , Bochimoto Hiroki , Kawabata Hidenobu , Umemiya-Shirafuji Rika , Kanuka Hirotaka , Fukumoto Shinya
Published: June 2024

Mosquito-borne diseases such as dengue and filariasis are a growing public health concern in endemic countries. Biological approaches, such as the trans-infection of Wolbachia pipientis in mosquitoes, are an alternative vector control strategy, especially for arthropod-borne viruses such as dengue. In the present study, the effect of Wolbachia (wMel strain) on the vectorial capacity of Aedes aegypti for Dirofilaria immitis was studied. Our results showed that Wolbachia does not affect the phenotype of mosquito survival or the prevalence, number, and molting rate of third-stage larvae in both susceptible and resistant strains of Ae. aegypti. RNA-seq analysis of Malpighian tubules at 2 days post-infection with D. immitis showed the differentially expressed genes (DEGs) with and without wMel infection. No characteristic immune-related gene expression patterns were observed among the DEGs. No significant change in the amount of Wolbachia was observed in the Ae. aegypti after D. immitis infection. Our results suggest that infection of D. immitis in Ae. aegypti populations will not interfere with Wolbachia-based vector control strategies in dengue-endemic areas where cases of D. immitis are present. This study demonstrated the veterinary medical validity of a dengue control program using Wolbachia.
Adaptive block sparse system identification in an impulsive interference environment
Authors: WU FEIYUN , Song Dan
Published: June 2024

To improve the accuracy of sparse system identification with impulsive measurement interference, a scaled least mean square (LMS) algorithm with block sparsity constraint is proposed. The proposed method adopts a scalar for scaling and filtering the impulsive interference. The proposed scalar avoids drastic changes in channel estimation due to the wrong information from the abrupt impulsive interference. On the other hand, by exploiting the sparsity of the system, the proposed block sparsity constraint searches sparse solution by using an approximated block $\ell_0$ norm constraint. Additionally, the step-size of the proposed method is gradually adjusted based on the gradient factors combining block sparse constraint and impulsive interference. Simulations, including sparse system identification and tracking, are conducted to confirm the effectiveness of the proposed algorithm for sparse system identification with impulsive interference. Moreover, this paper includes a comparison and analysis of underwater acoustic channel estimation results, demonstrating the superiority and effectiveness of the proposed algorithm.
Blood Volume Collected for Cultures in Infants with Suspected Neonatal Sepsis
Authors: Altez Maria Rueda , Soghier Lamia , Campos Joseph , Bahar Burak , Gai Jiaxiang , Bost James , Hamdy Rana
Published: June 2024

Objectives To evaluate blood culture sample volumes, identify factors linked to insufficient samples, and compare volumes among neonates treated for culture-negative-sepsis, sepsis-rule-outs, and bloodstream infections (BSI).Methods Observational cohort of blood cultures collected during NICU stay. Association of age, weight, gender, source, and collection time with lower-than-recommended volumes was determined by logistic regression. Blood culture inocula of patients with culture-negative-sepsis, sepsis rule-out, and BSI were compared using ANOVA.Results 742 blood cultures were obtained from 292 neonates. Median inoculum was 1mL (IQR:0.6–1.4), and 259 bottles (35%) had inocula < 0.9mL. Night shift sample collection was associated with lower-than-recommended volumes (p = 0.006). No difference in sample volumes was observed between culture-negative-sepsis, sepsis-rule-outs, and BSI (p = 0.5).Conclusions Median NICU blood culture volumes align with recommendations. Night shift collections correlate with lower volumes. Sample volumes don’t differ in patients with culture-negative-sepsis, BSI, and sepsis-rule-out, and should not be a justification for longer duration of antibiotics.