bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of pepper (Capsicum annuum L.) and rosemary (Rosmarinus officinalis L.) on pork quality
Authors:   Department of Commodity Science and Processing of Animal Raw Materials, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland, Śmiecińska Katarzyna
Published: January 2022

The aim of this study was to analyse the effect of pepper (Capsicum annuum L.) oleoresin (PO) and rosemary (Rosmarinus officinalis L.) extract (RE) on the quality of ground pork (m. longissimus dorsi). Vacuum-packaged pork samples were cold-stored for 4 weeks. The quality of meat without additives and with the addition of PO (0.4 and 0.2 g · kg–1 meat) and 4% RE (0.6 and 0.3 g · kg–1 meat) was evaluated. The pH of vacuum-packaged ground pork decreased during 4 weeks of storage in all experimental groups. The rate of lipid oxidation and changes in the colour and sensory properties of stored meat were determined by the type and quantity of natural antioxidants. Rosemary extract added at 0.6 g · kg–1 meat was the most potent inhibitor of lipid oxidation. Pepper oleoresin added at 0.4 g · kg–1 meat had the most beneficial influence on colour intensity evaluated instrumentally and colour desirability evaluated visually. Pork containing RE added at 0.3 g · kg–1 meat was characterised by the most desirable aroma and taste after storage.
FRAUDE Y DESNATURALIZACIÓN DE LA ASISTENCIASANITARIA GESTIONADA: EL CASO COLOMBIANO
Authors:   Universidad  Libre, PINEDA FLORO
Published: January 2022

The thesis why in Colombia is common to both some insurers as some operators,covered in managed health care, use cunning, deceit or machination in providinghealth care arises. For this reason, it is necessary to elucidate the fundamentals of practice instituting fraud and cost control through its various operatingmechanisms: secret operations to deny services, use skillful actions to inventbureaucratic procedures and denature managed healthcare, mechanisms thatare viewed from the concept of fraud and are understood from two differentareas: the environment conducive to immorality and the historicalunderstanding of the phenomenon.
Decision Support System of Student Education Assistance Using Analytical Hierarchy Process (AHP) Sunan Giri Foundation
Authors: Alawiyah Asromah Al , Yuana Haris , Puspitasari Wahyu Dwi
Published: January 2022

Student education assistance is a Foundation program for students to gain access to decent education services, prevent dropping out of school, attract poor students to return to school.  In its application, there are problems in determining, one of which is the inaccuracy of the recipient's target. This is due to the many tasks, obligations and work programs that must be completed on time by division. Therefore, the solution that can be done for time efficiency in helping the foundation is to create a system using the Analytical Hierarchy Process (AHP). Because the decision support system is able to solve management problems in producing the best alternative to support decisions taken by decision makers. The criteria used in this system are student status, average value of report cards, SKMT (Certificate of Disability), parental income, parental dependents, home ownership status and achievement. The results of the tests carried out using the black box testing method obtained an accuracy value of 70.58%, meaning that the application has run in accordance with the expected results, while the accuracy of the beta testing of the questionnaire results to the validator is 86% and the testing to prospective users is 87.81%.
Design and Build WEB-Based Applications as E-Commerce Media for Sales of Custom Products at CLOVE STORE Stores
Authors: Hidayah Nurul , Suryawinata Mohammad , Hindarto  , Astutik Ika Ratna Indra
Published: January 2022

E-commerce provides information about the items offered by business actors in the form of catalogs, which are given to make it easier for the general public or potential purchasers to select the required product. Making this e-commerce application is for owners who have full control over the e-commerce website or administrators who can enter data on products or services offered, while visitors to e-commerce websites can place orders for those products or services. The results of testing a website-based e-commerce application on the Clove Store store from the trials that have been carried out show that the success rate is 90%, In terms of the benefits of building an e-commerce website, there are many advantages, including for buyers, they don't need to come directly to the store, just by looking at the catalogs available on the website, buyers can directly order available products and for sellers in terms of promotion it will be easier and no need to spend more costs to market their products.
Raindrop Removal On A Single Image Using The Generative Adversarial Network
Authors: Muhammad Rizal Muttaqin1  , Oddy Virgantara Putra  , Lukman Effendi
Published: January 2022

The presence of raindrops attached to the window glass or vehicle glass reduces visibility of the actual scene. The area covered by raindrops forms a round image and reflects light from the actual scene, this image is called Raindrop. In some cases, the camera's focus is blocked by Raindrop will result in a blurry image. The problem faced is that there is no actual landscape image, so to overcome this this research tries to adapt the research from Rui Qian and MaybeShewill-CV which uses the Generative Adversarial Network architecture, by adding the Raindrop and Groundtruh datasets from observations at Darussalam Gontor University. The purpose of this study is to remove raindrops from a single image. This is important to research because it provides updates and optimizes the results of previous research. This study shows the accuracy of PSNR 21.37 and SSIM 0.7561. The model managed to remove Raindrops from the image, but still couldn't match the Groundtruth image. Inability to handle raindrops due to lack of time to run a large number of epochs to produce PSNR values ​​above 40 db and SSIM above 0.9. PSNR and SSIM values ​​can continue to increase along with the addition of the dataset as well as the number of epoch training models carried out.
Classification of Book Collections Based on DDC 23 Using Text Mining Algorithm at UNIDA Gontor Library
Authors: Muhammad Alwi  , Oddy Virgantara Putra  , Dihin Muriyatmoko1
Published: January 2022

The collection of books in a library is a means of information that has become the main actor as a supporter of the existence of a library. UNIDA Gontor library uses the 23rd edition of the Dewey Decimal Classification (DDC 23) classification system, as a reference for the classification numbering system for each book collection. However, in the classification numbering there is no automatic system that helps librarians in assigning classification numbering to each collection. So it is necessary to select a suitable model system to be applied to the automatic classification system. The data used in this study is in the form of blurb data on each collection of Indonesian public books in the UNIDA Gontor Library. In this study, four methods of text mining algorithms were applied to be tested and compared. The algorithm used in testing this research is Multinomial Nb, Logistic Regression, Random Forest, and Support Vector Classifier. From the test results, the highest accuracy results are the Support Vector Classifier algorithm of 72%, while the Logistic Regression algorithm is 69%, Random Forest 69%, and Multinomial Nb 59%. Further research is recommended to apply the support vector classifier algorithm into the UNIDA Gontor library information system.
Financial Data Processing Application On Optical Annisa Blitar
Authors: Sendi Dwi Jayanti  , Sri Lestanti  , Ni'ma Kholila
Published: January 2022

Information technology is growing faster, now with the presence of information technology, companies can do business more easily, one of which is the business of optics. Optik Annisa Jaya is one of the companies engaged in the field of glasses in the city of Blitar. Optik Annisa still has several shortcomings, one of which is a mechanism where obstacles in managing financial report data are still carried out by manual processing from recording sales transaction notes and recorded in sales transaction records so that it takes a long time. For making this application using the system development method, namely the method waterfall, a desktop-based application that uses php desktop as the interface design and SQLite as the database. The application testing process uses black box testing using the ISO 9126 standard. Based on the table of results of the assessment of Financial Data Processing Applications at Optik Annisa by media experts, media experts obtained an average feasibility percentage score of (89.5%) in the "Very Eligible" eligibility criteria with consider some suggestions from experts for future application development to be even better. With the creation of this application, it is hoped that it can help in easy financial management and can handle financial management problems at Optik Annisa.
Analysis Implementation Analytical Hierarchy Process Method and Weighted Product for Ranking Internet Package Selection System
Authors: Kusuma Abdi Pandu
Published: January 2022

The use of the internet is now with the increasing human need for information obtained using internet media. A decision support system (SPK) that is able to assist internet package users in determining the selection of internet packages and criteria can be used as a solution. This SPK implements the Analytical Hierarchy Process (AHP) and Weighted Product (WP) methods, the AHP method is used to determine the value of the weight criteria which is then used to calculate the WP method in determining the ranking of alternative internet packages. The criteria used in the AHP method include price, quota, signal quality, speed, and package type. The input data in the form of the weight value is calculated using the WP method to determine the best internet package. The results of the implementation of the AHP method were obtained on the criteria of price, quota, signal, speed, and package of 0.351; 0.279; 0.16; 0.14; and 0.07. The results of the implementation of the WP method based on the value of the weighting of the criteria from the results of processing the AHP method obtained Axis 1 GB data package as the selected internet package with a value of 0.256.
Freight fluidity for the Port of Baltimore : vessel approach and maritime mobility metrics
Authors: Kruse C. , Kang Dong Hun , Mitchell Kenneth , DiJoseph Patricia , Kress Marin
Published: January 2022

The United States Army Corps of Engineers is tasked with maintaining waterborne transportation system elements. Understanding channel utilization by vessels informs decisions regarding operations, maintenance, and investments in those elements. Historically, investment decisions have been informed by safety, environmental considerations, and projected economic benefits of alleviating channel restrictions or shipping delays (usually derived from models). However, quantifying causes and impacts of shipping delays based on actual historical vessel location data and then identifying which causes could be ameliorated through investment has been out of reach until recently. In this study, Automatic Identification System vessel position reports were used to develop quantitative measures of transit and dwell-time reliabilities for commercial vessels calling at the Port of Baltimore, Maryland. This port has two deep-water approaches: Chesapeake Bay and the Chesapeake and Delaware Canal. Descriptive metrics were determined for each approach, including port cycle time, harbor stay hours, travel time inbound, and travel time outbound. Then, additional performance measures were calculated: baseline travel time, travel time index, and planning time index. The key finding of this study is that the majority of variability in port cycle time is due to the variability in harbor stay hours, not from channel conditions or channel restrictions.
DEVELOPMENT OF ELECTRIC TRANSPORT IN THE REPUBLIC OF BELARUS ON THE BASIS OF PUBLIC-PRIVATE PARTNERSHIP IN THE CONDITIONS OF NEW GEOECONOMIC CHALLENGES AND THREATS
Authors: SOLODOVNIKOV S. , SERHIYEVICH T.
Published: January 2022

The article is devoted to the study of the development of the sphere of production and consumption of electric transport in the Republic of Belarus. The principles that should be laid down in the management of the development of this sphere in the Republic of Belarus have been worked out: firstly, a systematic approach that allows to determine the directions and tools for the development of electric transport in the context of the ongoing structural policy and modernization of the national industrial complex; secondly, the development of all types of electric transport, including for the purposes of both passenger and freight traffic; thirdly, import substitution in the production of electric transport components in order to increase the localization of the production of high-tech goods; fourth, the implementation of the cooperative potential in the industry of the Union State in order to gain access to unique resources and sales markets and unification of technical regulations; fifth, financing of fundamental and applied research in the development of electric transport and ensuring the transfer of their results to the real sector of the economy; sixth, a variety of forms of state support for the production and consumption of electric transport and related infrastructure. It is concluded that, taking into account the world experience, the most promising mechanism for the development of electric transport in the new geo-economic conditions is the use of public-private partnership.
ELECTRIC POWER SECTOR OF BELARUS: FORMATION, EVOLUTION, PROSPECTS FOR DEVELOPMENT IN THE CONDITIONS OF NEW INDUSTRIALIZATION
Authors: Baynev V.
Published: January 2022

The article presents a retrospective analysis of the development of the Belarusian electric
power industry, its current state, problems and prospects for its further improvement in the modern changed conditions. It is shown that in the context of external sanctions against Belarus and the surplus of electricity caused by the commissioning of the Belarusian NPP, it is necessary to revise the approaches to assessing the efficiency of sources of electrical energy and, accordingly, the directions of development of the domestic electric power industry. The general strategy of the Belarusian energy system is characterized, taking into account the need to implement a new industrialization of the national economy of the Republic of Belarus and other EAEU countries.
THEORETICAL AND METHODOLOGICAL FOUNDATIONS OF INTERACTION BETWEEN UNIVERSITIES AND INDUSTRIAL ENTERPRISES BASED ON THE TRIPLE HELIX MODEL IN THE CONTEXT OF MODERN TECHNOLOGICAL MODERNIZATION
Authors: Klimenko, V. , Drozdovich, L. , Kazantsava V.
Published: January 2022

The theoretical and methodological foundations of interaction between universities and industrial enterprises on the basis of the triple helix model in the context of modern technological modernization are clarified by developing theoretical and methodological principles of this interaction in the Republic of Belarus, namely: equality of ownership forms; recognition of multiple institutional forms of participation of universities in the capitalization of their technical, organizational and technological developments; creation of a triple helix communication network; the need to create a socio-scientific community; recognition of the uniqueness of organizational and economic mechanisms for the introduction of scientific developments in industry
Evaluation of Turkish Delight Prepared With Pigments And Essential Oils Extracted From Clementine (Citrus Clementine) Peels As Natural Antioxidants
Authors: Ibrahim Eman A. , Omran Azza A. , Salama Zeinab A.
Published: January 2022

This experiment presented essential oils by GC/MS, pigment content, and their antioxidant activities as well as sensory evaluation of delight samples. Limonene (66.88%) was the most prevalent yield. The peels of clementine had DPPH and ABT Scavenging activity. All levels of pigment extract had better scores for all sensory values and recorded acceptable scores in terms of appearance, color, aroma, and overall acceptability compared to control delight. Besides, delight samples containing 15 mg astaxanthin pigment extract showed maximum sensory scores compared to other samples and control delight. On the other hand, the product was less acceptable to the panelists compared to control in the case of the addition of 3.75 mg astaxanthin pigment extract. All the analyzed samples showed that delight fortified with astaxanthin pigment which has high contents of essential oils has good antioxidant activities. As a general conclusion, Clementine peels are recommended as a useful value-added functional ingredient for the food industry as natural additives that will be healthier than artificial additives.
Ethics and Religious Consciousness in the Philosophy of Kiyozawa Manshi (1863–1903)
Authors:   Institute of Oriental studies Russian Academy of Sciences, Lepekhova Elena S.
Published: January 2022

This paper deals with the problem of the correlation between ethics and religious consciousness in the philosophy of the Japanese scholar, philosopher and publicist Kiyozawa Manshi (1863–1903). Analyzing various ethical systems (utilitarianism, intuitionism, rigorism and rationalism), in the discourse about what is the primary one: public morality or religious consciousness, he comes to the conclusion that the structure of individual and social life should be based primarily on the principles of spirituality (seishinshugi). To the individual following only ethical norms without realizing his spiritual nature seems difficult, and sometimes simply impossible. Spirituality itself, according to Kiyozawa Manshi, has a clearly expressed Buddhist meaning: it is the absolute transcendental truth of the Buddha Amida Tathagata, the infinite (mugen) principle that underlies everything and can determine ethical norms. The philosophical views of Kiyozawa Manshi are of special interest, demonstrating a situation, influenced by the change of socio-political conditions, ethics and religious preferences in society where, in response, the most educated representatives sought to establish their own standards of morality and spirituality, in which religion played a formative role.
The Innovative Paradigm of Applied Ethics: A Mission (Not)Feasible?
Authors:   Industrial University of Tyumen, Bakshtanovsky Vladimir I. , Bogdanova Marina V. ,   Industrial University of Tyumen
Published: January 2022

The article examines the project-oriented potential of the conceptual direction “Innovative paradigm of applied ethics”, which was formed in Russia in the second half of the XX and early XXI centuries. The basis of this direction is formed by theoretical ethical knowledge, project-oriented knowledge for the purposeful transformation of “small systems”, phronesis (that is the ability to understand and interpret the situation at hand and decide about appropriate actions). The main issue under discussion is the relevance of the project-oriented potential of applied ethics in the knowledge of modern situations of moral choice. The experience of applying the project-oriented potential of the innovative paradigm of applied ethics in the context of the transformation of a Russian university is analyzed. Experience, which is presented on the pages of the journal “Semestrial Papers Applied Ethics”. The dynamics of the features of the application of ethical and applied knowledge to the study of changing situations is fixed: theoretical comprehension of new situations of moral choice; recognition of choice alternatives; project-oriented impact on the value-normative system; humanitarian examination of the conflict interaction of value systems. It is concluded that the mission of the innovative paradigm of applied ethics from the point of view of its project-oriented potential is feasible when applied to situations of uncertainty in moral choice, when there is a request from the acting subject for humanitarian expertise, consulting and project activities. In the absence of a situation of moral choice, with a decrease in the possibility of self-determination of the acting subject, and a reduction in the sphere of his responsibility, the mission of the innovative paradigm of applied ethics is hardly feasible. At the same time, the nature of ethical issues in a changing society indicates a potential demand for project-oriented potential of applied ethics in the near future.
Is Palamism a Form of Classical Theism, Theistic Personalism, Panentheism, or What? Some Conceptual Clarification for Analytic Philosophers
Authors:   Concordia University of Edmonton, Dumsday Travis
Published: January 2022

The precise understanding of “classical theism” varies somewhat within analytic philosophy of religion. Sometimes it is understood as something like a synonym for generic Christian theism (in contrast to deism or pantheism or the theisms of other world religions). Alternatively, the label is often understood by reference to a specific understanding of the doctrine of divine simplicity (namely that promulgated by such figures as Augustine, Anselm, and Aquinas) and the larger conception of God which flows from it. The latter usage of the label is quite common within the recent literature, such that classical theism in this sense is viewed as competing with other prominent ways of conceptualizing Christian theism, notably panentheism, theistic personalism, and open theism. Where does the Palamite understanding of God (normative within Eastern Orthodox theology) fall within a contemporary taxonomy of Christian theisms? I seek to answer this question. By way of a literature review consulting representative contemporary sources on the various alternative theisms plus Palamism, I clarify the distinctive commitments of each position and draw out their assorted conceptual relationships and interconnections. I then go on to suggest that Palamism is uniquely well-situated to function as a bridge-builder and corrective force within the current literature, capable of dialoguing productively with the aforementioned range of Christian theisms.
Rational Theology in the System of Fundamental Theology Metropolitan Macarius (Bulgakov)
Authors:   St. Petersburg Theological Academy, Lushnikov Dmitry
Published: January 2022

The article attempts to critically examine the first textbook on fundamental theology in Russian Academic theological school (lntroduction to Orthodox Theology), written by Metropolitan Macarius (Bulgakov) (1816–1882) who is much more renown for his authoritative volumes on dogmatics and history of the Church and can be regarded as the founder of Russian Academic systematical theology in general. The author of the article is the first one to have scrutinized Macarius’ contribution into rational theology here. He reveals the strengths and weaknesses of the Macarius’ presentation of the rational justifications for the existence of God and the immortality of the soul, which he, like Thomas Aquinas, called the paths of knowledge of God. It is shown that arguments for the existence of God presented by him are mainly complementary, with the exception of the fourth, known in modern rational theology as “Argument from religious experience”. The author discloses that “the first path” of Metropolitan Macarius combines historical and ontological arguments, “the second path” cosmological and teleological, the third one ontological and moral. It is emphasized that among the significant shortcomings of Metropolitan Macarius’ presentation of these arguments are the absence of references to Western authors who formulated the arguments he used, and, most importantly, complete disregard for Kant's criticism of these “proofs”. The truth of the immortality of the soul is also presented, according to the author’s analysis, unconvincingly, although it contains a number of arguments that are productive for rational theology. The author also offers a comprehensive assessment of the system of Orthodox theology of Metropolitan Macarius by his contemporaries, the main complaints of his critics being concerning the dryness and “schooliness” of his style. The conclusion of the article deals with the positive significance of the Introduction as the first experience of building a system of theological knowledge in the aspect of the formation and development of fundamental theology in Russia including fundamental elements of rational theology. The article opens perspectives for the further scrutiny of rational theology within Russian Orthodox Academic tradition to begin with such a renown disciple of Metropolitan Macarius as Nikanor (Brovkovich).
On Roger Pouivet’s Religious Exclusivism
Authors:   University of Urbino, Aguti Andrea
Published: January 2022

In the contemporary discussion of religious diversity, religious exclusivism is a minority theory but well defended by some leading philosophers of religion like Alvin Plantinga. Recently, in his article, The Right to Believe that Only One Religion is True, published recently in “Philosophy of Religion: Analytic Researches”, Roger Pouivet has defended a version of religious exclusivism based on the assumption of theological realism. In this article, I discuss Pouivet’s religious exclusivism with a dual purpose. On the one hand, accepting the premises of theological realism, I agree with Pouivet’s view that religious exclusivism is not a blatant expression of arrogance about religious diversity but a plausible theory that can be justified in the light of the contemporary debate on epistemology of religious disagreement. On the other hand, I sustain that theological realism supports religious exclusivism as well as religious inclusivism, but the latter is a more consistent theory, capable of avoiding the soteriological problems raised by the first. In this perspective, I suggest that religious inclusivism is properly supported by natural theology insofar as the latter relates to divine attributes which are common to various religious traditions. Accordingly, natural theology must not be reduced, like Pouivet thinks, to a philosophical theology that assumes the immediate rationality of religious beliefs, guaranteed by the way they are formed. On the contrary, I suggest that natural and philosophical theology can work together, in their distinction, to rationally justify theistic faith and the belief that only one religion is true. In the light of the aforesaid one can believe that the issue of the correlation between philosophical theology and natural theology has sound methodological significance in various contexts of studies in philosophy of religion.
Single-stage C6-7 ACDF with T1-2 Oblique Keyhole Transcorporeal Disectomy to Treat Cervico-thoracic Tandem Disc Herniation: A Case Report
Authors: Moon Kang Suk , Jeong MinSeung , Lee Sang-Ho , Baek Oon-Ki
Published: January 2022

Symptomatic cervico-thoracic tandem disc herniation occurs very rarely. On the other hand, cervical disc herniations are common and may be treated via a variety of surgical procedures. Symptomatic upper thoracic disc herniations are extremely rare, and use of a surgical approach in their treatment is controversial due to the narrow operative space within which surgical procedures must be performed. We report an extremely rare case of symptomatic tandem C6-7 and T1-2 disc herniation successfully treated via single-stage, single-incision, C6-7 anterior cervical decompression and fusion, and T1-2 oblique keyhole transcorporeal discectomy. This is the first symptomatic cervico-thoracic tandem disc herniation with its treatment.
A Representation of L-domain by Formal Concept Analysis
Authors: shengwen Wang , Li Qingguo
Published: January 2022

In this paper, we represent L-domains by means of Formal Concept Analysis. Based on the attributive continuous formal contexts, we propose the notions of LDF-contexts and G-locally connections, and show that they provide concrete representations of L-domains and Scott-continuous functions between them, respectively. Moreover, the category of LDFcontexts with morphisms G-locally connections is proven to be equivalent to that of L-domains with morphisms Scott-continuous functions.
Real-time prediction and ponding process early warning method at urban flood points based on different deep learning methods
Authors: Zhou Yihong , Wu Zening , Jiang Mengmeng , Xu Hongshi , Yan Denghua , Wang Huiliang , He Chentao , Zhang Xiangyang
Published: January 2022

Accurate prediction of urban floods is regarded as one of the critical means to prevent urban floods and reduce the losses caused by floods. However, due to the uncertainty and complexity of urban floods and waterlogging, it is very difficult to use simulation models to quickly and accurately predict and warn of urban floods. Therefore, it is necessary to develop new methods to support the rapid and accurate prediction of urban floods and waterlogging. In this study, a refined prediction and early warning method for urban flood and waterlogging processes based on deep learning methods is proposed from three aspects: research feasibility, method applicability, and method system. The spatial autocorrelation of rain and ponding points is analyzed by Moran's I. For each ponding point, the relationship model between the rainfall process and ponding process is constructed based on different deep learning methods, and the results are analyzed and verified by a statistical evaluation method. The results show that the gradient boosting decision tree algorithm has the highest accuracy and efficiency (with a root mean square error of 0.001) for ponding process prediction and is regarded as the most suitable method for ponding process prediction. Finally, the real-time prediction and early warning of urban floods and waterlogging processes driven by rainfall forecast data are realized, and the results are verified by the measured data. In addition, the results of the sensitivity analysis show that the rainfall peak and location coefficient have the greatest impact on ponding.
Treatment Outcome of Tuberculosis and Associated Factors Among MTB/HIV Co-infected Patients in Sichuan, China: A Cross-Sectional Study (2016-2020)
Authors: Yang Ni , Chen Chuang , Li Jing , Zhong Yin , He Jinge , Xia Lan , Zhang Linglin , Gao Wenfeng , Zhang Shu
Published: January 2022

Background: Mycobacterium tuberculosis/Human immunodeficiency virus (MTB/HIV) co-infection has increasingly become a pressing global public health problem. TB patients co-infected with HIV have poorer treatment outcome as compared to non-HIV-infected TB patients.This study was conducted to assess the outcomes of TB treatment and their associated factors among MTB/HIV co-infected patients in Sichuan, Southwest of China. Methods: A cross-sectional study was performed among all of the MTB/HIV co-infected patients who were diagnosed and registered in TB designated hospitals and health facilities in Sichuan from 1st January 2016 to 31st December 2020. The data was collected from patients’ electronic medical records regarding patients’ demographic, clinical as well as their social support information. We calculated proportions of factors and treatment outcomes by Pearson’s chi-square test and Fisher’s exact test. Binary logistic regression model was fitted to identify factors associated with unsuccessful TB treatment outcome. For the logistic regression performed using alpha=0.05, odds ratios and corresponding 95% confidence intervals were calculated for the various risk factors. Results: We included a total of 3183 registered MTB/HIV co-infected patients. Of the total patients, 89.54% had successful outcomes, 10.46% had unfavourable outcomes. Of the total successful outcomes, 21.49% were cured, 68.05% had completed their treatment. Being above 60 years old, received TB treatment at the municipal medical institute [AOR=2.093, 95%CI:1.219-3.593], diagnosed with EPTB [AOR=2.067, 95% CI:1.503-2.842], Relapsed or returned treatment after default [AOR=1.593, 95%CI:1.048-2.420], being sputum smear positive [AOR=1.636, 95%CI: 1.290-2.075] were the factors that resulted the patients in unsuccessful treatment outcome. Conclusion: Particular attention is recommended for MTB/HIV co-infected patients who are over 60 years old, receiving medical aid in the city-level medical institute, EPTB, relapsed or returned after default, sputum smear positive. National TB programme should strengthen social support and collaborative MTB/HIV management activities that would trace the identified factors in TB and HIV/AIDS designated health facilities to improve successful treatment outcome of TB.
Ficus Dubia Latex Extract Prevent DMH-Induced Rat Colorectal Carcinogenesis Through the Regulation of Xenobiotic Metabolism, Inflammation, Cell Proliferation and Apoptosis
Authors: Hu Rentong , Chantana Weerachai , Pitchakarn Pornsiri , Subhawa Subhawat , Chantarasuwan Bhanumas , Temviriyanukul Piya , Chewonarin Teera
Published: January 2022

Ficus dubia latex is recognized as a remedy in Asian traditional medicine with various therapeutic effects. The present study aimed to determine the preventive action of Ficus dubia latex extract (FDLE) on 1,2-dimethylhydrazine (DMH) -induced rat colorectal carcinogenesis and its mechanisms. The experiment included an initiation model in which rats were orally administered with FDLE daily for one week before DMH injection until the end of the experiment, while only after DMH injection until the end in the post-initiation model. The results firstly indicated that FDLE treatment could reduce the level of methylazoxymethanol (MAM) in rat colonic lumen by inhibition of the activities of both phase I xenobiotic metabolizing enzymes in the liver and β-glucuronidase in the colon, leading to reduced DNA methylation in colonic mucosal cells, related to the number of ACF in the initiation stage. Besides, FDLE modulated the inflammation which could suppress the growth and induce apoptosis of aberrant colonic mucosal cells, leading to retardation of ACF multiplicity. Therefore, FDLE showed the ability to suppress the DMH-induced rat ACF formation and inflammation promoted growth of ACF. In conclusion, FDLE had the potential to prevent multistage colorectal carcinogenesis in rat received carcinogens.
Renewable Rice Straw Cellulose Nanofibril Reinforced Poly (ε-caprolactone) Composite Films
Authors: Qiao Xiuying , Wang Zengyi , Sun Kang
Published: January 2022

In this study, cellulose nanofibrils (CNFs) fabricated from rice straw were utilized to reinforce poly (ε-caprolactone) (PCL), and the structure and properties of these CNF/PCL composite films were analyzed by morphology observation and the characterization of X-ray diffraction (XRD), differential scanning calorimeter (DSC), thermogravimetric analyzer (TGA), mechanical property and water absorption tests. The experimental results revealed that in PCL matrix, CNF exhibits a homogeneous distribution at low content, but shows some aggregates at high content. The incorporation of CNFs doesn’t change the crystal type, crystallinity and melting temperature of PCL, but accelerates the crystallization of PCL due to the heterogeneous nucleating agent effect of CNF. Compared with PCL film, the CNF/PCL composite films show obvious improvement of mechanical strength and Young’s modulus. However, after the CNF content exceeds 10%, the tensile strength of the composite films begins to decrease, and high loading of CNFs also causes remarkable negative influences on the thermal stability and hydrophobicity of the composite films.
Impact of reinforcement on the load-settlement behavior of a strip footing adjacent to granular soil excavation
Authors: Ahmad Hussein
Published: January 2022

By adding a geogrid, the granular soils are improved as far as their load-settlement behavior is concerned. It is often necessary to build new buildings adjacent to existing buildings because of a shortage of urban land. It is necessary, therefore, to excavate. An excavation's surface foundations have less information on their behavior. Two types of granular soil were employed in experiments using finite elements in a series of numerical analyses near excavations loaded with a strip footing to investigate reinforced and unreinforced granular soils. The simulation of granular soil behavior is therefore carried out using the hardening soil model (HSM). A couple of closed footings adjacent to the pit were investigated to evaluate the effect of the geogrid reinforcement on their behavior during the response to load. In this research, footing spacing from various granular excavation edges varied with sand excavations (H=3B). The highest bearing capacity was achieved using various geogrid layers. By utilizing three existing reinforcement layers and increasing the pit setback, it is demonstrated that the final settlement of the footings can be greatly reduced. Based on the findings of this study, the final loading capacity could be increased considerably when three layers of reinforcement are applied to granular soils. Furthermore, the bearing capacity will also increase in a nonlinear manner as the excavation is distanced from its edge. Consequently, it is important to determine the location of the footings carefully. A second advantage is the ability to place foundations adjacently, which increases their bearing capacity and efficiency factor. There is no effect on the effect of interference when the distance between the surface foundations (D) is more than 5 times the foundation width (B).
Improving Failure Analysis Efficiency Of Handling Equipment By Using FMECA
Authors: Essalhi Rachida Rouabhia , Boukrouh El Hadi , Ghemari Youcef
Published: January 2022

This work is part of an applied research study on the most commonly used methods in the industry: Failure Mode, Effects and Criticality Analysis (FMECA). In this study, the method was applied more precisely in an industrial production environment in a company responsible for producing and marketing various materials for public works and construction. During the elaboration of a preventive maintenance program for one of its equipment, (handling equipment) newly installed “the Pellegrini 10T overhead crane”, the company noticed that it is very important to understand precisely its behavior in case of failure to prevent its dysfunction or that of one of its components. This study aims to reduce the potential failures of handling equipment in the industry by using FMECA, which will help avoid potential risks and reduce downtime.
Does the cardiac cycle affect decision-making under uncertainty?
Authors: Kimura Kenta , Kanayama Noriaki , Katahira Kentaro
Published: January 2022

This study investigates whether decision-making under uncertainty is influenced by one's cardiac cycle. To test this, we examine the influence of the cardiac cycle on an individual's decision-making process in a gambling experiment. Participants are asked to choose one option with a sure payout or uncertain options with varying degrees of winning probability, ambiguity, and monetary amounts. To manipulate the cardiac cycle, the presentation of the options is timed to coincide with either the individual's cardiac systole or diastole. The results show that for most participants, the risk aversion score is lower in the systole trial than that in the diastole trial. The model-based exploratory analysis reveals that the higher propensity to take risks in the systole trial compared with that in the diastole trial could be captured better by the change in the gambling bias for/against the utility of the risky options, rather than by a change in risk attitude. The results provide evidence that the natural fluctuation of cardiac afferent signals can affect one's decision-making under uncertainty.
Vertical root fracture resistance and crack formation of root canal-treated teeth restored with different post-luting systems
Authors: Rathke Andreas , Frehse Henry , Hrusa Beatrice
Published: January 2022

To investigate the vertical root fracture (VRF) resistance and crack formation of root canal-treated teeth restored with different post-luting systems. Human maxillary lateral incisors of similar size were decoronated, assigned to five groups (n = 18, power = 0.9) and embedded in acrylic blocks with artificial periodontium. After root canal filling, post spaces were prepared and coated fiber-reinforced composite (FRC) or sandblasted titanium (TIT) posts of the same shape and size were placed. Half of the posts were zinc phosphate cemented (C), while the other half was adhesively luted (A). Untreated teeth served as control. After thermal cycling and staircase loading in a chewing simulator, the crack formation on the root dentin surface was microscopically examined and classified as no defect, craze line, vertical crack, and horizontal crack. Subsequently, the samples were loaded until root fracture. Data were analyzed by one-way ANOVA, Tukey's test, and Fisher's exact test. All samples survived the chewing simulation without VRF, but crack formation was significantly different between the groups (P = 0.009). The control showed significantly fewer defects than FRC/C, TIT/C, and TIT/A (P = 0.001, P = 0.008, P = 0.008, respectively). FRC/C showed the highest incidence of vertical cracks. FRC/A had the lowest incidence of defects. There was no significant difference in VRF resistance between the groups (P = 0.265). Adhesively luted FRC posts did not increase VRF resistance but reduced the risk of defects. Most defects were craze lines and vertical root cracks.
The Effectiveness, Impact, and Viability of Culinary Medicine in Medical Programs: A Systematic Review
Authors: Tan Jacqueline , Rao Tanish , Atamanchuk Levi , Sato Kenichi , Crowley Jennifer , Ball Lauren
Published: January 2022

Background: Dietary modifications are considered a first-line intervention for chronic disease management, yet graduating doctors still report not feeling competent to counsel patients on their diet. Research has focused on methods to address this shortfall in physician competency, including culinary medicine. Culinary medicine is an approach to education that involves hands-on food and cooking learning experiences to equip participants with tools for improving the nutrition behaviour and health of their future patients. Despite positive findings in the efficacy of these interventions, they differ markedly in approach and target, leading to difficulties in deriving a global standardised curriculum. Methods: This systematic review aims to address this inconsistency by synthesising existing literature on culinary medicine interventions that are offered during medical training; specifically, those with a hands-on culinary skills component. This entails an assessment of the effectiveness, impact, and viability of such programs as well as a comparison to existing curricula to provide specific recommendations for future programs. Results: The findings of this research demonstrate a clear increase in interest in the use of hands-on culinary medicine programs as educational tools, evidence of feasibility in implementation, and improved student nutritional knowledge, skill and counseling compared to a traditional didactic curriculum. However, variations exist in delivery method, setting, and course content between programs. There is also lack of program cost reportingand long-term follow up of participants, inconsistent evidence for improved nutrition attitudes amongst participants, as well as geographically limited adoption of such programs. Conclusions: By searching the current literature body for programs that address hands-on culinary skills within the context of medical education, this study reveals the potential benefits and existing short comings of such programs. These findings will guide future research towards legitimising culinary medicine into globally accepted standards for medical education.
HBV preS mutations promote hepatocarcinogenesis by inducing endoplasmic reticulum stress and up-regulating inflammatory signaling
Authors: Cao Guangwen , Liu Wenbin , Pu Rui , Cai Shiliang , Li Zixiong , Liu Donghong , Zhou Xinyu , Yin Jianhua , Chen Xi , Chen Liping , Wu Jianfeng , Tan Xiaojie , Wang Xin
Published: January 2022

We aimed to elucidate the effects and underlying mechanisms of hepatitis B virus (HBV) preS mutations on hepatocarcinogenesis. The association between preS mutations and hepatocellular carcinoma (HCC) occurrence was evaluated using a cohort of 2114 HBV-infected patients. Combo mutations G2950A/G2951A/A2962G/C2964A and C3116T/T31C significantly increased HCC risk in patients without antiviral treatment, whereas preS2 deletion significantly increased the HCC risk in patients who received antiviral treatment. The preS1/preS2/S mutants and their wild-type counterpart were delivered into Sleeping Beauty (SB) mouse models. preS1/preS2/S mutants induced a higher tumor rate and higher serum levels of inflammatory cytokines than did wild type-preS1/preS2/S in SB mice. The preS1/preS2/S mutants induced dramatic alteration of gene expression profiles partially through inducing pro-oncogenic inflammatory cytokine. Through enhancing the retention of HBV S protein in endoplasmic reticulum (ER), the preS1/preS2/S mutants enhanced ER stress, induced the alteration in metabolism, affected the response to hypoxia, and upregulated the protein level of signal transducer and activator of transcription 3 (STAT3). Inhibiting the STAT3 pathway attenuated the positive effects of preS1/preS2/S mutants on cell proliferation. Thus, G2950A/G2951A/A2962G/C2964A, C3116T/T31C, and preS2 deletion promote hepatocarcinogenesis via inducing ER stress, metabolism, and pro-oncogenic STAT3 inflammatory pathways, which can be transformed into specific prophylaxis of HCC.
The Local Toxicity of Cobalt Chrome implants: A Systematic Review of Preclinical Studies
Authors: Zais Ilaria E. , Sammali Susanna , Pavan Matilde , Chisari Emanuele , Krueger Chad A.
Published: January 2022

Metal-on-metal total hip arthroplasty prostheses are known to release cobalt and chrome (CoCr) debris. The local accumulation of these ions and nanoparticles can cause adverse local tissue reaction, which can ultimately determine a negative outcome for patients. The aim of our systematic review was to report the latest evidence on the effects of CoCr particles on local soft tissue with a focus on its clinical relevance. PubMed, Embase, and Cochrane Library databases were screened to perform an extensive review. PRISMA guidelines were applied, and the risk of bias was assessed, as was the methodological quality of the included studies. 27 studies were included after applying the inclusion and exclusion criteria. 3 were human ex vivo studies, 24 were preclinical studies, including 21 in vitro and 3 in animal models. The presence of metal ions results in cell damage by reducing cell viability, inducing DNA damage, and triggering the secretion of cytokines, which are responsible for the inflammatory reaction observed in ALTR. CoCr particles released from MoM implants can cause damage to skeletal muscle, the capsule, and provoke osteolysis and inflammation. The cytotoxic and genotoxic damages, as well as the interaction with the immune system, affect the success of the arthroplasty and lead to a higher rate of revision surgeries. Statement of clinical significance: Ions released from the wear of Metal-on-Metal implant are significantly associated with soft tissue damage, and other local adverse reaction. Multiple mechanistic reasons are proposed.