bluuebunny/crossref_metadata_2025 huggingface dataset:
The “Vertigo” of the Food Sector within the Triangle of Climate Change, the Post-Pandemic World, and the Russian-Ukrainian War
Authors: Galanakis Charis M.
Published: February 2023

Over the last few years, the world has been facing dramatic changes due to a condensed period of multiple crises, including climate change, the COVID-19 pandemic, and the Russian–Ukrainian war. Although different, these consecutive crises share common characteristics (e.g., systemic shocks and non-stationary nature) and impacts (e.g., disruption of markets and supply chains), questioning food safety, security, and sustainability. The current article analyses the effects of the noted crises in the food sector before proposing target mitigation measures to address the different challenges. The goal is to transform the food systems to increase their resilience and sustainability. This goal can only be achieved if all relevant actors within the supply chain (e.g., governments, companies, distributors, farmers, etc.) play their role by designing and implementing target interventions and policies. In addition, the transformation of the food sector should be proactive concerning food safety, circular (valorizing several bioresources under the principles of climate neutral economy and blue bioeconomy), digital (based on Industry 4.0 applications), and inclusive (ensuring that all citizens are actively engaged). Food production modernization (e.g., by implementing emerging technologies) and developing shorter and more domestic supply chains are also critical to achieving food resilience and security.
Investigation on the Contents of Nε-carboxymethyllysine, Nε-carboxyethyllysine, and N-nitrosamines in Commercial Sausages on the Chinese Market
Authors: Wang Wenjing , Kou Yafei , Du Yanli , Li Mingyu , Zhang Jian , Yan Aiping , Xie Jianhua , Shen Mingyue
Published: February 2023

Sausages are among the most popular meat products worldwide. However, some harmful products, such as advanced glycation end-products (AGEs) and N-nitrosamines (NAs), can be formed simultaneously during sausage processing. In this study, the contents of AGEs, NAs, α-dicarbonyls and the proximate composition were investigated in two kinds of commercial sausages (fermented sausages and cooked sausages) in the Chinese market. The correlations among them were further analyzed. The results showed that the fermented and cooked sausages had different in protein/fat contents and pH/thiobarbituric acid reactive substance values due to their different processing technologies and added ingredients. The Nε-carboxymethyllysine (CML) and Nε-carboxyethyllysine (CEL) concentrations varied from 3.67 to 46.11 mg/kg and from 5.89 to 52.32 mg/kg, respectively, and the NAs concentrations ranged from 1.35 to 15.88 µg/kg. The contents of some hazardous compounds, such as CML, N-nitrosodimethylamine, and N-nitrosopiperidine, were observed to be higher in the fermented sausages than in the cooked sausages. Moreover, levels of NAs in some sausage samples exceeded the limit of 10 µg/kg issued by the United States Department of Agriculture, suggesting that particular attention should be paid to mitigating NAs, especially in fermented sausages. The correlation analysis suggested that the levels of AGEs and NAs were not significantly correlated in both kinds of sausages.
Effects of Omega-3 Fatty Acids Supplementation on Serum Lipid Profile and Blood Pressure in Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Liu Yin-Xiu , Yu Jun-Hui , Sun Ji-Han , Ma Wen-Qin , Wang Jin-Jing , Sun Gui-Ju
Published: February 2023

The purpose of this study was to explore the effect of omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplementation on serum lipid profile and blood pressure in patients with metabolic syndrome. We searched PubMed, Web of Science, Embase, and the Cochrane library from database inception to 30 April 2022. This meta-analysis included eight trials with 387 participants. We found that supplementation of n-3 PUFAs has no significant reduction in TC level (SMD = −0.02; 95% CI: −0.22 ~ 0.18, I2 = 23.7%) and LDL-c level in serum (SMD = 0.18; 95% CI: −0.18 ~ 0.53, I2 = 54.9%) of patients with metabolic syndrome. Moreover, we found no significant increase in serum high-density lipoprotein cholesterol level (SMD = 0.02; 95% CI: −0.21 ~ 0.25, I2 = 0%) in patients with metabolic syndrome after consuming n-3 PUFAs. In addition, we found that n-3 PUFAs can significantly decrease serum triglyceride levels (SMD= −0.39; 95% CI: −0.59 ~ −0.18, I2 = 17.2%), systolic blood pressure (SMD = −0.54; 95% CI: −0.86 ~ −0.22, I2 = 48.6%), and diastolic blood pressure (SMD = −0.56; 95% CI: −0.79 ~ 0.33, I2 = 14.0%) in patients with metabolic syndrome. The results from the sensitivity analysis confirmed that our results were robust. These findings suggest that n-3 PUFA supplementation may serve as a potential dietary supplement for improving lipids and blood pressure in metabolic syndrome. Given the quality of the included studies, further studies are still needed to verify our findings.
Multi-Target Detection of Nuts and Peanuts as Hidden Allergens in Bakery Products through Bottom-Up Proteomics and High-Resolution Mass Spectrometry
Authors: Luparelli Anna , Losito Ilario , De Angelis Elisabetta , Pilolli Rosa , Monaci Linda
Published: February 2023

Due to the growing global incidence of allergy to nuts and peanuts, the need for better protection of consumers sensitive to those products is constantly increasing. The best strategy to defend them against adverse immunological reactions still remains the total removal of those products from their diet. However, nuts and peanuts traces can also be hidden in other food products, especially processed ones, such as bakery products, because of cross-contamination occurring during production. Precautionary labelling is often adopted by producers to warn allergic consumers, usually without any evaluation of the actual risk, which would require a careful quantification of nuts/peanuts traces. In this paper, the development of a multi-target method based on liquid chromatography-tandem high resolution mass spectrometry (LC-MS, MS/MS), able to detect traces of five nuts species (almonds, hazelnuts, walnuts, cashews and pistachios) and of peanuts in an in-house incurred bakery product (cookie) through a single analysis is described. Specifically, allergenic proteins of the six ingredients were used as the analytical targets, and the LC-MS responses of selected peptides resulting from their tryptic digestion, after extraction from the bakery product matrix, were exploited for quantification, following a bottom-up approach typical of proteomics. As a result, nuts/peanuts could be detected/quantified down to mg·kg−1 levels in the model cookie, thus opening interesting perspectives for the quantification of hidden nuts/peanuts in bakery products and, consequently, for a more rational use of precautionary labelling.
Selective Activity of an Anthocyanin-Rich, Purified Blueberry Extract upon Pathogenic and Probiotic Bacteria
Authors: Silva Sara , Costa Eduardo M. , Machado Manuela , Morais Rui M. , Calhau Conceição , Pintado Manuela
Published: February 2023

Blueberry extracts have been widely recognized as possessing antimicrobial activity against several potential pathogens. However, the contextualization of the interaction of these extracts with beneficial bacteria (i.e., probiotics), particularly when considering the food applications of these products, may be of importance, not only because their presence is important in the regular gut microbiota, but also because they are important constituents of regular and functional foodstuffs. Therefore, the present work first sought to demonstrate the inhibitory effect of a blueberry extract upon four potential food pathogens and, after identifying the active concentrations, evaluated their impact upon the growth and metabolic activity (organic acid production and sugar consumption) of five potential probiotic microorganisms. Results showed that the extract, at a concentration that inhibited L. monocytogenes, B. cereus, E. coli and S. enteritidis (1000 μg mL−1), had no inhibitory effect on the growth of the potential probiotic stains used. However, the results demonstrated, for the first time, that the extract had a significant impact on the metabolic activity of all probiotic strains, resulting in higher amounts of organic acid production (acetic, citric and lactic acids) and an earlier production of propionic acid.
A New Modeling of Fractional-Order and Sensitivity Analysis for Hepatitis-B Disease with Real Data
Authors: Yavuz Mehmet , Özköse Fatma , Susam Muhittin , Kalidass Mathiyalagan
Published: February 2023

In this study, we propose new illustrative and effective modeling to point out the behaviors of the Hepatitis-B virus (Hepatitis-B). Not only do we consider the mathematical modeling, equilibria, stabilities, and existence–uniqueness analysis of the model, but also, we make numerical simulations by using the Adams–Bashforth numerical scheme. However, we apply the parameter estimation method to determine our model parameters and find the curve that best fits the model. Additionally, in this study, the stability analysis of the aforementioned model is considered, and also the sensitivity analysis of R0 is examined. The results point out that the order of the fractional derivative has an essential effect on the dynamical process of the constructed model for Hepatitis-B.
Vapor Phase Ammonia Curing to Improve the Mechanical Properties of Antireflection Optical Coatings Designed for Power Laser Optics
Authors: Avice Jérémy , Brotons Guillaume , Ruello Pascal , Vaudel Gwenaëlle , Guediche Amira , Piombini Hervé
Published: February 2023

Projects of inertial confinement fusion using lasers need numerous optical components whose coatings allow the increase in their transmission and their resistance to high laser fluence. A coating process based on the self-assembly of sol–gel silica nanoparticles and a post-treatment with ammonia vapor over the surfaces of the optical components (“ammonia curing process”) was developed and successfully optimized for industrial production. Manufacturing such antireflective coatings has clear advantages: (i) it is much cheaper than conventional top-down processes; (ii) it is well adapted to large-sized optical components and large-scale production; and (iii) it gives low optical losses in transmission and high resistances to laser fluence. The post-treatment was achieved by a simple exposition of optical components to room-temperature ammonia vapors. The resulting curing process induced strong optical and mechanical changes at the interface and was revealed to be of paramount importance since it reinforced the adhesion and abrasion resistance of the components so that the optical components could be handled easily. Here, we discuss how such coatings were characterized and how the initial thin nanoparticle film was transformed from a brittle film to a resistant coating from the ammonia curing process.
Construction of Engineered Muscle Tissue Consisting of Myotube Bundles in a Collagen Gel Matrix
Authors: Furusawa Kazuya , Kawahana Yuuki , Miyashita Ryoya
Published: February 2023

Tissue engineering methods that aim to mimic the hierarchical structure of skeletal muscle tissue have been widely developed due to utilities in various fields of biology, including regenerative medicine, food technology, and soft robotics. Most methods have aimed to reproduce the microscopical morphology of skeletal muscles, such as the orientation of myotubes and the sarcomere structure, and there is still a need to develop a method to reproduce the macroscopical morphology. Therefore, in this study, we aim to establish a method to reproduce the macroscopic morphology of skeletal muscle by constructing an engineered muscle tissue (EMT) by culturing embryonic chicken myoblast-like cells that are unidirectionally aligned in collagen hydrogels with micro-channels (i.e., MCCG). Whole mount fluorescent imaging of the EMT showed that the myotubes were unidirectionally aligned and that they were bundled in the collagen gel matrix. The myotubes contracted in response to periodic electrostimulations with a frequency range of 0.5–2.0 Hz, but not at 5.0 Hz. Compression tests of the EMT showed that the EMT had anisotropic elasticity. In addition, by measuring the relaxation moduli of the EMTs, an anisotropy of relaxation strengths was observed. The observed anisotropies could be attributed to differences in maturation and connectivity of myotubes in the directions perpendicular and parallel to the long axis of the micro-channels of the MCCG.
Modeling of Liquid Hydrogen Tank Cooled with Para-Orthohydrogen Conversion
Authors: Matveev Konstantin I. , Leachman Jacob W.
Published: February 2023

With the accelerating development of liquid-hydrogen storage facilities, the problem of boil-off hydrogen losses becomes very important. A promising method to reduce these losses is to utilize the endothermic para-orthohydrogen conversion of vented hydrogen, which can effectively decrease heat loads on a hydrogen tank. To model such a process, a hybrid computational model has been developed, based on the application of computational fluid dynamics for an ullage space, where knowledge of thermal stratification is important, and reduced-order models for other system elements. The simulation results for a spheroidal tank in selected conditions indicated a 10–25% reduction of boil-off losses due to cooling produced by vented hydrogen undergoing para-ortho-conversion.
Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children
Authors: Zwierz Aleksander , Domagalski Krzysztof , Masna Krystyna , Burduk Paweł
Published: February 2023

Background: The aim of this study was to compare adenoid size in preschool-age siblings using flexible nasopharyngoscopy examination (FNE) when they reach the same age. The occurrence of adenoid symptoms in these patients was also analyzed. This study was conducted to analyze the adenoid size in siblings when they reach the same age and substantiate a correlation between adenoid hypertrophy (AH) and adenoid symptoms. Methods: We analyzed and reported on the symptoms, ENT examination results, and FNE of 49 pairs of siblings who were examined at the same age. Results: There was a strong association in adenoid size between siblings when they are at a similar age (r = 0.673, p < 0.001). Second-born children whose older sibling had IIIo AH (A/C ratio > 65%) had a risk of IIIo AH 26 times greater than patients whose older sibling did not have IIIo AH (OR = 26.30, 95% CI = 2.82–245.54). Over 90% of snoring children whose siblings had confirmed IIIo AH would develop IIIo AH by the time they reach the same age. Second-born children in whom snoring occurs and whose older siblings have a IIIo AH have about a 46 times higher risk of IIIo AH compared to patients who did not meet these two conditions (p < 0.001, OR = 46.67, 95% CI = 8.37–260.30). Conclusions: A significant familial correlation between adenoid size in siblings when they reach the same age was shown. If the older sibling has a confirmed overgrown adenoid (IIIo AH) and their younger sibling presents adenoid symptoms, particularly snoring, it is highly probable that they will also have an overgrown adenoid.
Impacts of Air Pollution on Health and Cost of Illness in Jakarta, Indonesia
Authors: Syuhada Ginanjar , Akbar Adhadian , Hardiawan Donny , Pun Vivian , Darmawan Adi , Heryati Sri Hayyu Alynda , Siregar Adiatma Yudistira Manogar , Kusuma Ririn Radiawati , Driejana Raden , Ingole Vijendra , Kass Daniel , Mehta Sumi
Published: February 2023

(1) Background: This study aimed to quantify the health and economic impacts of air pollution in Jakarta Province, the capital of Indonesia. (2) Methods: We quantified the health and economic burden of fine particulate matter (PM2.5) and ground-level Ozone (O3), which exceeds the local and global ambient air quality standards. We selected health outcomes which include adverse health outcomes in children, all-cause mortality, and daily hospitalizations. We used comparative risk assessment methods to estimate health burdens attributable to PM2.5 and O3, linking the local population and selected health outcomes data with relative risks from the literature. The economic burdens were calculated using cost-of-illness and the value of the statistical life-year approach. (3) Results: Our results suggest over 7000 adverse health outcomes in children, over 10,000 deaths, and over 5000 hospitalizations that can be attributed to air pollution each year in Jakarta. The annual total cost of the health impact of air pollution reached approximately USD 2943.42 million. (4) Conclusions: By using local data to quantify and assess the health and economic impacts of air pollution in Jakarta, our study provides timely evidence needed to prioritize clean air actions to be taken to promote the public’s health.
Volumetric Assessment of Apical Periodontitis Using Cone-Beam Computed Tomography—A Systematic Review
Authors: Mackiewicz Ewa , Bonsmann Tobias , Kaczor-Wiankowska Kinga , Nowicka Alicja
Published: February 2023

This systematic review aimed to investigate the scientific literature on volumetric studies concerning the diagnosis and treatment of apical periodontitis using CBCT. A systematic review protocol was written following the preferred reporting items for the systematic reviews and meta-analyses (PRISMA) checklist. Four electronic databases were searched for relevant publications in English, which were published up to 21 January 2023. The inclusion criteria and corresponding search keys were applied. The risk of bias was assessed using the Joanna Briggs Institute Meta-Analysis of Statistic Assessment and Review Instrument. The search strategy identified 202 studies, with 123 studies excluded during the title and abstract screening and 47 studies left for full text screening. A total of 17 studies met the inclusion criteria. The lesion volume was measured and classified according to different indices which compared the effectiveness of their diagnostics. Moreover, the volume of AP lesions increased with the thickness of the maxillary sinus mucosa in primary and secondary infections and decreased due to endodontic treatment. Volumetric measurements using CBCT are useful in the correct definition of periapical tissue pathosis using a CBCT periapical volume index and assessment of the dynamics of the treatment of apical lesions.
Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
Authors: Ryu Jin Suk , Kim So Yeon , Kim Mee Kum , Oh Joo Youn
Published: February 2023

Recent evidence shows that epithelial stem/progenitor cells in barrier tissues such as the skin, airways and intestines retain a memory of previous injuries, which enables tissues to accelerate barrier restoration after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, is the frontline barrier for the eye and is maintained by epithelial stem/progenitor cells in the limbus. Herein, we provide evidence that inflammatory memory also exists in the cornea. In mice, eyes that had been exposed to corneal epithelial injury exhibited faster re-epithelialization of the cornea and lower levels of inflammatory cytokines following subsequent injury (either the same or a different type of injury) relative to naïve eyes without previous injury. In ocular Sjögren’s syndrome patients, corneal punctate epithelial erosions were significantly reduced after experiencing infectious injury compared with before. These results demonstrate that previous exposure of the corneal epithelium to inflammatory stimuli enhances corneal wound healing in response to a secondary assault, a phenomenon which points to the presence of nonspecific inflammatory memory in the cornea.
Use of Brain-Derived Stem/Progenitor Cells and Derived Extracellular Vesicles to Repair Damaged Neural Tissues: Lessons Learned from Connective Tissue Repair Regarding Variables Limiting Progress and Approaches to Overcome Limitations
Authors: Hart David A.
Published: February 2023

Pluripotent neural stem or progenitor cells (NSC/NPC) have been reported in the brains of adult preclinical models for decades, as have mesenchymal stem/stromal cells (MSC) been reported in a variety of tissues from adults. Based on their in vitro capabilities, these cell types have been used extensively in attempts to repair/regenerate brain and connective tissues, respectively. In addition, MSC have also been used in attempts to repair compromised brain centres. However, success in treating chronic neural degenerative conditions such as Alzheimer’s disease, Parkinson’s disease, and others with NSC/NPC has been limited, as have the use of MSC in the treatment of chronic osteoarthritis, a condition affecting millions of individuals. However, connective tissues are likely less complex than neural tissues regarding cell organization and regulatory integration, but some insights have been gleaned from the studies regarding connective tissue healing with MSC that may inform studies attempting to initiate repair and regeneration of neural tissues compromised acutely or chronically by trauma or disease. This review will discuss the similarities and differences in the applications of NSC/NPC and MSC, where some lessons have been learned, and potential approaches that could be used going forward to enhance progress in the application of cellular therapy to facilitate repair and regeneration of complex structures in the brain. In particular, variables that may need to be controlled to enhance success are discussed, as are different approaches such as the use of extracellular vesicles from stem/progenitor cells that could be used to stimulate endogenous cells to repair the tissues rather than consider cell replacement as the primary option. Caveats to all these efforts relate to whether cellular repair initiatives will have long-term success if the initiators for neural diseases are not controlled, and whether such cellular initiatives will have long-term success in a subset of patients if the neural diseases are heterogeneous and have multiple etiologies.
A Review on Concrete Composites Modified with Nanoparticles
Authors: Huseien Ghasan Fahim
Published: February 2023

Recently, various nanomaterials have extensively been used to achieve sustainability goals in the construction sector. Thus, this paper presents a state-of-the-art review involving the uses of different nanomaterials for production of high-performance cementitious, geopolymer, and alkali-activated concrete composites. The effects of nanomaterials on the fresh properties, mechanical properties, and durability of diverse nanoparticle-modified concrete composites are analyzed. The past developments, recent trends, environmental impact, sustainability, notable benefits, and demerits of various nanomaterial-based concrete production are emphasized. It is demonstrated that nanomaterials including SiO2, Al2O3, TiO2, and Fe2O3, etc., can be used effectively to enhance the microstructures and mechanical characteristics (such as compressive strength, flexural, and splitting tensile strengths) of the modified concrete composites, thus improving their anti-erosion, anti-chloride penetration, and other durability traits. In short, this communication may provide deep insight into the role of diverse nanoparticle inclusion in concrete composites to improve their overall attributes.
Match Load Physical Demands in U-19 Professional Soccer Players Assessed by a Wearable Inertial Sensor
Authors: Pillitteri Guglielmo , Giustino Valerio , Petrucci Marco , Rossi Alessio , Leale Ignazio , Bellafiore Marianna , Thomas Ewan , Iovane Angelo , Palma Antonio , Battaglia Giuseppe
Published: February 2023

Background: Wearable inertial sensors are poorly used in soccer to monitor external load (EL) indicators. However, these devices could be useful for improving sports performance and potentially reducing the risk of injury. The aim of this study was to investigate the EL indicators (i.e., cinematic, mechanical, and metabolic) differences between playing positions (i.e., central backs, external strikers, fullbacks, midfielders, and wide midfielder) during the first half time of four official matches (OMs). Methods: 13 young professional soccer players (Under-19; age: 18.5 ± 0.4 years; height: 177 ± 6 cm; weight: 67 ± 4.8 kg) were monitored through a wearable inertial sensor (TalentPlayers TPDev, firmware version 1.3) during the season 2021–2022. Participants’ EL indicators were recorded during the first half time of four OMs. Results: significant differences were detected in all the EL indicators between playing positions except for two of them (i.e., distance traveled in the various metabolic power zones (<10 w) and the number of direction changes to the right >30° and with speed >2 m). Pairwise comparisons showed differences in EL indicators between playing positions. Conclusions: Young professional soccer players showed different loads and performances during OMs in relation to playing positions. Coaches should consider the different physical demands related to playing positions in order to design the most appropriate training program.
Detection of Pneumocystis and Morphological Description of Fungal Distribution and Severity of Infection in Thirty-Six Mammal Species
Authors: Weissenbacher-Lang Christiane , Blasi Barbara , Bauer Patricia , Binanti Diana , Bittermann Karin , Ergin Lara , Högler Carmen , Högler Tanja , Klier Magdalena , Matt Julia , Nedorost Nora , Silvestri Serenella , Stixenberger Daniela , Ma Liang , Cissé Ousmane H. , Kovacs Joseph A. , Desvars-Larrive Amélie , Posautz Annika , Weissenböck Herbert
Published: February 2023

Pneumocystis spp. are thought to adapt to the lungs of potentially all mammals. However, the full host range, fungal burden and severity of infection are unknown for many species. In this study, lung tissue samples originating from 845 animals of 31 different families of eight mammal orders were screened by in situ hybridization (ISH) using a universal 18S rRNA probe for Pneumocystis, followed by hematoxylin and eosin (H&E) staining for determining histopathological lesions. A total of 216 (26%) samples were positive for Pneumocystis spp., encompassing 36 of 98 investigated mammal species, with 17 of them being described for the first time for the presence of Pneumocystis spp. The prevalence of Pneumocystis spp. as assessed by ISH varied greatly among different mammal species while the organism load was overall low, suggesting a status of colonization or subclinical infection. Severe Pneumocystis pneumonia seemed to be very rare. For most of the Pneumocystis-positive samples, comparative microscopic examination of H&E- and ISH-stained serial sections revealed an association of the fungus with minor lesions, consistent with an interstitial pneumonia. Colonization or subclinical infection of Pneumocystis in the lung might be important in many mammal species because the animals may serve as a reservoir.
Psychometric Properties of Suboptimal Health Status Instruments: A Systematic Review
Authors: Alzain Mohamed Ali , Asweto Collins Otieno , Hassan Sehar-un-Nisa , Saeed Mohammed Elshiekh , Kassar Ahmed , Alsaif Bandar
Published: February 2023

Background: Suboptimal health status (SHS) measurement has now been recognized as an essential construct in predictive, preventive, and personalized medicine. Currently, there are limited tools, and an ongoing debate about appropriate tools. Therefore, it is crucial to evaluate and generate conclusive evidence about the psychometric properties of available SHS tools. Objective: This research aimed to identify and critically assess the psychometric properties of available SHS instruments and provide recommendations for their future use. Methods: Articles were retrieved by following the guidelines of the PRISMA checklist, and the robustness of methods and evidence about the measurement properties was assessed using the adapted COSMIN checklist. The review was registered in PROSPERO. Results: The systematic review identified 14 publications describing four subjective SHS measures with established psychometric properties; these included the Suboptimal Health Status Questionnaire-25 (SHSQ-25), Sub-health Measurement Scale Version 1.0 (SHMS V1.0), Multidimensional Sub-health Questionnaire of Adolescents (MSQA), and the Sub-Health Self-Rating Scale (SSS). Most studies were conducted in China and reported three reliability indices: (1) the internal consistency measured by Cronbach’s α value ranged between 0.70 and 0.96; (2) the test–retest reliability; and (3) the split-half reliability coefficient values ranged between 0.64 and 0.98, and between 0.83 and 0.96, respectively. For the values of validity coefficients in the case of SHSQ-25 > 0.71, the SHMS-1.0 ranged from 0.64 to 0.87, and the SSS ranged from 0.74 to 0.96. Using these existing and well-characterized tools rather than constructing original tools is beneficial, given that the existing choice demonstrated sound psychometric properties and established norms. Conclusions: The SHSQ-25 stood out as being more suitable for the general population and routine health surveys, because it is short and easy to complete. Therefore, there is a need to adapt this tool by translating it into other languages, including Arabic, and establishing norms based on populations from other regions of the world.
Understanding the Healthcare Needs of Immigrant Children Currently and Previously in Government Custody: A Narrative
Authors: La Charite Jaime , Tucker Elizabeth W. , Rosenberg Julia , Young Janine , Gupta Nikita , Hoops Katherine
Published: February 2023

Little is known of pediatric clinicians’ experiences with and approaches to taking care of immigrant children who have been in US custody. The objectives of this article are to (1) recognize the challenges facing pediatric clinicians in caring for immigrant children previously in custody, and (2) propose ways that healthcare and legal professionals can collaborate to optimize the wellbeing of formerly detained immigrant children. We identify themes by assessing answers to multiple choice and short responses from a national survey. These findings can help to identify current issues faced by both detained immigrant children and pediatric clinicians, and suggest approaches to addressing these issues.
Clinical Biomarker of Sterile Inflammation, HMGB1, in Patients with Chronic Non-Specific Low Back Pain: A Pilot Cross-Sectional Study
Authors: Teodorczyk-Injeyan Julita A. , Khella Heba , Injeyan H. Stephen
Published: February 2023

The present study explores whether the inflammatory biomarker of sterile inflammation, high mobility box 1 (HMGB1), contributes to the inflammatory/nociceptive pathophysiology that characterizes chronic non-specific low back pain (LBP). Patients with chronic LBP (N = 10, >3 pain score on a 11-point Visual Analogue Scale, VAS) and asymptomatic participants (N = 12) provided peripheral blood (PB) samples. The proportion of classical CD14++ monocytes within PB leukocytes was determined by flow cytometry. The plasma and extracellular HMGB1 levels in unstimulated adherent cell (AC) cultures were measured using specific immunoassays. HMGB1 localization in ACs was assessed by immunofluorescent staining. The relative gene expression levels of tumor necrosis factor α (TNFα), interleukin-1 beta (IL-1β) and HMGB1 were determined by quantitative polymerase chain reaction (qRT-PCR) in relation to the pain intensity (11-point VAS scores) in patients with LBP. The extracellular release of HMGB1 in the LBP patient AC cultures was significantly elevated (p = 0.001) and accompanied by its relocation into the cytoplasm from the nuclei. The number of CD14++ monocytes in the patients’ PB was significantly (p = 0.03) reduced, while the HMGB1 plasma levels remained comparable to those of the controls. The mRNA levels of TNFα, IL-1β and HMGB1 were overexpressed relative to the controls and those of HMGB1 and IL-1β were correlated with the VAS scores at a significant level (p = 0.01–0.03). The results suggest that HMGB1 may play an important role in the pathophysiology of chronic non-specific LBP.
Natural Co-Exposure to Borrelia burgdorferi s.l. and Anaplasma phagocytophilum: Unraveling the Hematological Profile in Sheep
Authors: Athanasiou Labrini V. , Tsokana Constantina N. , Gougoulis Dimitris A. , Tzivara Athanasia H. , Dedousi Anna , Katsoulos Panagiotis D.
Published: February 2023

The occurrence of co-infected hosts and questing ticks with more than one tick-borne pathogen—as in the case of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato—is expected in endemic regions. Their synergy—in terms of pathogenesis and disease severity—has been suggested previously in humans. Limited data exist on the clinicopathological alterations in co-infected sheep. In this study, we investigated the impact of A. phagocytophilum and B. burgdorferi s.l. seropositivity, alone and in combination, on the hematological parameters of naturally infected sheep. A complete blood count was performed, and indirect immunofluorescence assays were used to detect IgG antibodies against A. phagocytophilum and IgG and IgM antibodies against B. burgdorferi s.l. Single natural exposure to B. burgdorferi s.l. was characterized by low Packed Cell Volume (PCV) values and platelet (PLT) counts, while single exposure to A. phagocytophilum was characterized by low PCV values, low white blood cell (WBC) counts, and an increased risk for leukopenia and neutropenia. Co-exposure resulted in the most severe blood abnormalities; all the blood parameters decreased, and the sheep presented an increased risk for anemia. Our study showed that natural co-exposure to A. phagocytophilum and B. burgdorferi s.l. in sheep leads to more severe blood abnormalities and enhances the pathogenic processes. More studies are needed to clarify the possible background mechanisms.
Effects of Oxide Fragments on Microstructure and Mechanical Properties of AA6061 Aluminum Alloy Tube Fabricated by Thermomechanical Consolidation of Machining Chips
Authors: Zhang Zhen , Liang Jiamiao , Xia Tian , Xie Yuehuang , Chan Sammy Lap Ip , Wang Jun , Zhang Deliang
Published: February 2023

An AA6061 aluminum alloy tube was fabricated by compacting machining chips via thermomechanical consolidation, including hot pressing and hot extrusion. The microstructure evolution and formation of oxide particles were investigated in correlation to tensile mechanical properties. It was found that fine Al/Mg oxide particles were formed due to the fracture of oxide layers on the chips and the reaction between Mg and Al2O3 during hot extrusion. The oxide particles inhibited the growth of recrystallized α-Al grains, leading to the formation of a microstructure consisting of coarse elongated grains with sizes of 420 μm and fine equiaxed grains with sizes of 10 μm. After T6 heat treatment, a microstructure with finer grains (grain sizes: 34 μm) formed due to further recrystallization induced by residual strain. The tensile mechanical properties testing results indicated that a good combination of strength (296 MPa) and ductility (7.6%) was achieved in the T6 heat treated samples, which were likely attributed to the high-quality inter-chip bonding, as well as the fine oxide particles which were small enough that further crack nucleation and growth around them were inhibited during tensile deformation. For the purpose of comparison, the microstructure and mechanical properties of the as-extruded and T6 heat treated samples produced by hot extrusion of the cast ingot of AA6061 aluminum alloy were also investigated. The lower tensile strength of solid-state recycled tube sample might be associated with the consumption of Mg atoms by the oxidation reaction, leading to the lower density of β″ precipitates in precipitation strengthening.
Dismantling of Reinforced Concrete Using Steam Pressure Cracking System: Drilling and Crack Propagation
Authors: Kamiya Osamu , Takahashi Mamoru , Miyano Yasuyuki , Ito Shinichi , Murata Kenji , Kawano Makoto , Maisawa Arata , Nanao Jumpei , Kazumi Takashi , Nakatsu Masanobu , Mizuma Hiroyuki , Miyota Tatsuya , Nagao Kota , Iwama Yuichi
Published: February 2023

This study investigated a new dismantling system for concrete structures using a steam pressure cracking agent. We improved the mechanical systems such that it can drill through reinforcing steel bars. Therefore, the control method of the system and shape of the drill tip were improved. When the drill tip is stuck with chips and stopped, it is automatically pulled out and reinserted to recover the rotation. By changing the tip angle of the drill bit from 75° to 90°, it became possible to cut reinforcing bars, which were difficult to cut previously. In addition, we designed a crawler-type mechanical system and improved it such that it can be moved to the appropriate position and operated at any angle. This study revealed that the energy required for the drilling process accounts for more than 90% of the total dismantling energy. Through experiments using an impact hammer drill and observations of fracture surfaces using a three-dimensional scanner, we analysed the characteristics of reinforced concrete. In addition, the feasibility of the design for dismantling reinforced concrete was confirmed based on the determined energy associated with crack propagation.
Manipulation of the Martensitic Transformation and Exchange Bias Effect in the Ni45Co5Mn37In13 Ferromagnetic Shape Memory Alloy Films
Authors: Wen Jiahong , Yang Bochu , Dong Zhichao , Yan Yaxin , Zhao Xiaoyu
Published: February 2023

The martensitic phase transition and exchange bias effect of the Ni-Mn-based ferromagnetic shape memory alloys (FSMAs) Ni45Co5Mn37In13 (Ni-Co-Mn-In) films are investigated in this paper. The martensitic transformation properties of the Ni-Co-Mn-In alloy target material are manipulated by the process of electric arc melting, melt-fast quenching, and high-temperature thermal pressure. The Ni-Co-Mn-In alloy films with martensite phase transition characteristics are obtained by adjusting deposition parameters on the (001) MgO substrate, which shows a significant exchange bias (EB) effect at different temperatures. With increasing sputtering power and time, the film thickness increases, resulting in a gradual relaxation of the constraints at the interface between the film and the substrate (the interfacial strain decreases as the increase of thin film thickness), which promotes the martensite phase transition. Between zero-field cooling (ZFC) and field-cooled (FC) curve obvious division zone, the decrease of exchange bias field (HEB) and coercive force field (Hc) with an increase in test temperature is due to ferromagnetic (FM) interaction begins to dominate, resulting in a reduction of antiferromagnetic (AFM) anisotropy at the interface. The maximal HEB and Hc reach ~465.7 Oe and ~306.9 Oe at 5 K, respectively. The manipulation of the martensitic transformation and EB effect of the Ni-Co-Mn-In alloy films demonstrates potential application in the field of information and spintronics.
Modified Picard-like Method for Solving Absolute Value Equations
Authors: Liang Yuan , Li Chaoqian
Published: February 2023

We present a modified Picard-like method to solve absolute value equations by equivalently expressing the implicit fixed-point equation form of the absolute value equations as a two-by-two block nonlinear equation. This unifies some existing matrix splitting algorithms and improves the efficiency of the algorithm by introducing the parameter ω. For the choice of ω in the new method, we give a way to determine the quasi-optimal values. Numerical examples are given to show the feasibility of the proposed method. It is also shown that the new method is better than those proposed by Ke and Ma in 2017 and Dehghan and Shirilord in 2020.
Chemical MHD Hiemenz Flow over a Nonlinear Stretching Sheet and Brownian Motion Effects of Nanoparticles through a Porous Medium with Radiation Effect
Authors: Salah Faisal , Sidahmed Abdelmgid O. M. , Viswanathan K. K.
Published: February 2023

In this paper, the numerical solutions for magneto-hydrodynamic Hiemenz fluid over a nonlinear stretching sheet and the Brownian motion effects of nanoparticles through a porous medium with chemical reaction and radiation are studied. The repercussions of thermophoresis and mass transfer at the stagnation point flow are discussed. The plate progresses in the contrary direction or in the free stream orientation. The underlying PDEs are reshaped into a set of ordinary differential equations employing precise transformation. They are addressed numerically using the successive linearization method, which is an efficient systematic process. The main goal of this study is to compare the solutions obtained using the successive linearization method to solve the velocity and temperature equations in the presence of m changes, thereby demonstrating its accuracy and suitability for solving nonlinear differential equations. For comparison, tables containing the results are presented. This contrast is significant because it demonstrates the accuracy with which a set of nonlinear differential equations can be solved using the successive linearization method. The resulting solution is examined and discussed with respect to a number of engineering parameters. Graphs exemplify the simulation of distinct parameters that govern the motion factors.
The Pathogenic Diagnosis in Pediatric Diabetology: Next Generation Sequencing and Precision Therapy
Authors: Maione Giovanna , Iafusco Fernanda , Zanfardino Angela , Piscopo Alessia , Ozen Gulsum , Iafusco Dario , Tinto Nadia
Published: February 2023

In pediatric diabetology, a precise diagnosis is very important because it allows early and correct clinical management of the patient. Monogenic diabetes (MD), which accounts for 1–6% of all pediatric–adolescent diabetes cases, is the most relevant example of precision medicine. The definitive diagnosis of MD, possible only by genetic testing, allows us to direct patients to more appropriate therapy in relation to the identified mutation. In some cases, MD patients can avoid insulin and be treated with oral hypoglycemic drugs with a perceptible impact on both the quality of life and the healthcare costs. However, the genetic and phenotypic heterogeneity of MD and the overlapping clinical characteristics between different forms, can complicate the diagnostic process. In recent years, the development of Next-Generation Sequencing (NGS) methodology, which allows the simultaneous analysis of multiple genes, has revolutionized molecular diagnostics, becoming the cornerstone of MD precision diagnosis. We report two cases of patients with clinical suspects of MD in which a genetic test was carried out, using a NGS multigenic panel, and it clarified the correct pathogenesis of diabetes, allowing us to better manage the disease both in probands and other affected family members.
How Did the Two Years of the COVID-19 Pandemic Affect the Outcomes of the Patients with Inflammatory Rheumatic Diseases in Lithuania?
Authors: Dadonienė Jolanta , Jasionytė Gabija , Mironova Julija , Staškuvienė Karolina , Miltinienė Dalia
Published: February 2023

Background and objectives: the COVID-19 pandemic globally caused more than 18 million deaths over the period of 2020–2021. Although inflammatory rheumatic diseases (RD) are generally associated with premature mortality, it is not yet clear whether RD patients are at a greater risk for COVID-19-related mortality. The aim of our study was to evaluate mortality and causes of death in a retrospective inflammatory RD patient cohort during the COVID-19 pandemic years. Methods: We identified patients with a first-time diagnosis of inflammatory RD and followed them up during the pandemic years of 2020–2021. Death rates, and sex- and age-standardized mortality ratios (SMRs) were calculated for the prepandemic and pandemic periods. Results: We obtained data from 11,636 patients that had been newly diagnosed with inflammatory RD and followed up until the end of 2021 or their death. The mean duration of the follow-up was 5.5 years. In total, 1531 deaths occurred between 2013 and 2021. The prevailing causes of death in the prepandemic period were cardiovascular diseases, neoplasms, and diseases of the respiratory system. In the pandemic years, cardiovascular diseases and neoplasms remained the two most common causes of death, with COVID-19 in third place. The SMR of the total RD cohort was 0.83. This trend was observed in rheumatoid arthritis and spondyloarthropathy patients. The SMR in the group of connective-tissue diseases and vasculitis was higher at 0.93, but did not differ from that of the general population. The excess of deaths in the RD cohort during the pandemic period was negative (−27.2%), meaning that RD patients endured the pandemic period better than the general population did. Conclusions: The COVID-19 pandemic did not influence the mortality of RD patients. Strict lockdown measures, social distancing, and early vaccination were the main factors that resulted in reduced mortality in this cohort during the pandemic years.
Tongue Base Ectopic Thyroid Tissue—Is It a Rare Encounter?
Authors: Constantin Balica Nicolae , Marina Trandafir Cornelia , Eugen Stefanescu Horatiu , Ileana Enatescu , Adrian Gluhovschi
Published: February 2023

Failure in the embryological development of the thyroid in adults is rarely seen. We present the case of a 79-year-old female patient who complained of dysphagia and progressive upper respiratory obstruction, which started 12 months prior to her admission. An ENT clinical exam revealed a tongue base, spherical, well-defined tumour covered by normal mucosa. Further assessments established the diagnosis of the tongue base ectopic thyroid tissue. Due to the patient’s symptoms, a transhyoid tongue base tumour removal was performed. The selected patient gave consent for participation and inclusion in this paper, in compliance with the 1964 Helsinki declaration.
Integration of Remote Sensing and Field Data in Ophiolite Investigations: A Case Study of Logar Ophiolite Complex, SE Afghanistan
Authors: Yousufi Atal , Ahmadi Hemayatullah , Bekbotayeva Alma , Arshamov Yalkunzhan , Baisalova Akmaral , Omarova Gulnara , Pekkan Emrah
Published: February 2023

Mafic–ultramafics complexes are crucial for their tectonic implication, upper mantle condition, and for hosting industrial minerals in a region. This study aims to highlight and characterize the mafic–ultramafic rocks of the Logar Ophiolite Complex using the integration of geospatial technology and field data. The spatial distribution of the ophiolitic complex was examined in this study using the mineralogical indices (MI), band ratio (BR), and spectral angle mapper (SAM) methods within the framework of geospatial technology using Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data. Additionally, several samples were collected from the identified complexes for validation, petrographic, and mineralogical analyses. Combining geospatial technology and conventional approaches, e.g., field sampling and geological data analysis yields efficient discrimination of mafic–ultramafic rocks with their associated hydrothermal altered minerals. The serpentinization and carbonate processes are predominantly seen along the eastern side of the active fault zone following the detection of ophiolites. Detailed mapping of the ophiolitic complex and associated rocks was achieved using refined mafic index (MI), band ratio 12/14 and 4/8 for rocks and SAM for highlighting the mafic–ultramafic altered minerals, and petrographic analysis of the collected samples. The field works verified the results of the ASTER data. The findings of this study can significantly contribute to detailed tectonic and geologic studies of the detected ophiolites in terms of their emplacement mechanism and ages.