bluuebunny/crossref_metadata_2025 huggingface dataset:
Quasioptimal Spacecraft Attitude Control Constructed According to the Poinsot Concept
Authors: Sapunkov Yakov G. , Molodenkov Alexei V.
Published: April 2023

The problem of attitude optimal control of a spacecraft as a solid body with the energy spent on maneuvering a spacecraft taken as a quadratic functional, and a fixed transition time, is investigated. The dynamic configuration of a spacecraft and boundary conditions on an attitude and angular velocity are arbitrary; the control function is not limited. According to the Poinsot concept from theoretical mechanics on the interpretation of the angular motion of a solid body around a fixed point and with the help of the Pontryagin maximum principle, the quasioptimal analytical solution of the problem is obtained, which is brought to the algorithm. Numerical examples are provided that confirm the closeness of the quasioptimal solution to the optimal solution of the problem.
Design of a Spring-Finger Potato Picker and an Experimental Study of Its Picking Performance
Authors: Wang Lihe , Liu Fei , Wang Qiang , Zhou Jiaqi , Fan Xiaoyu , Li Junru , Zhao Xuan , Xie Shengshi
Published: April 2023

To address the problems of low pickup rates and high rates of wounds in the mechanised harvesting of potatoes under sectional harvesting conditions, a spring-finger potato picker was designed and its overall structure and working principles were described. The kinematic principle of the spring-finger was analysed based on the picking constraints, and the kinematic parameters of the picker were determined. A response surface Box–Behnken Design test design was used to carry out a quadratic orthogonal rotational test, with the speed of the spring-finger, the forward speed of the machine, and the embedded depth as test factors, and the loss rate and the wounded potato rate as evaluation indicators. The test results were optimised and analysed. When the spring-finger speed was 19.57 r/min, the forward speed was 0.61 m/s and the embedded depth was 71.31 mm, the loss rate was 1.18%, and the wounded potato rate was 5.71%. The optimised data were verified, and the results showed that the loss rate of the spring-finger potato picker was 1.48% and the wounded potato rate was 4.98%, meeting the potato picking and harvesting requirements. The research can provide a theoretical basis and design reference for the development and application of sectional potato harvesting machinery.
Identification of Candidate Genes for Drought Resistance during Soybean Seed Development
Authors: Tang Xiaofei , Xue Yongguo , Cao Dan , Luan Xiaoyan , Zhao Kezhen , Liu Qi , Ren Yang , Zhu Zifei , Li Yong , Liu Xinlei
Published: April 2023

Drought is the main abiotic stress limiting soybean production worldwide and seriously limits the reproductive growth of soybean. To elucidate the molecular mechanisms of drought stress response in soybean seed developmental stages, transcriptome analysis was performed on five seed developmental stages under drought stress and control conditions. Thousands of genes were found to change in expression level under drought stress, GO and KEGG enrichment analysis showed that differentially expressed genes (DEGs) were involved in drought resistance at every stage or tissue, but there were very few DEGs at the primary stage of seed development, which indicated that the seeds at the primary developmental stage were influenced little by drought stress. There was no shared DEG among all five stages or tissues, this indicated that they have different mechanisms to resist drought stress. Furthermore, we investigated DEGs associated with drought response at different stages to identify candidate regulators of drought stress response during soybean seed development. These genes are associated with metabolic and regulatory networks, among others. Taken together, the results will expand our understanding of the adaptation of soybean to drought stress and provide new insights into the molecular mechanisms of soybean drought tolerance development.
Combined Application of Coffee Husk Compost and Inorganic Fertilizer to Improve the Soil Ecological Environment and Photosynthetic Characteristics of Arabica Coffee
Authors: Jiang Zeyin , Lou Yuqiang , Liu Xiaogang , Sun Wenyan , Wang Haidong , Liang Jiaping , Guo Jinjin , Li Na , Yang Qiliang
Published: April 2023

Excessive use of chemical fertilizers deteriorates the soil environment and limits the normal growth of Arabica coffee trees. In order to identify the optimal coupling mode of chemical fertilizer application and biomass return that enhances the soil ecological environment and promotes the photosynthetic efficiency of Arabica coffee, this study investigated the impacts of three levels of inorganic fertilizers (FL: 360 kg·ha−1, FM: 720 kg·ha−1, and FH: 1080 kg·ha−1) and three types of coffee husk returning methods (CB: coffee husk biochar, CC: coffee husk compost, CA: coffee husk ash) on the soil fertility, microbial amount, enzyme activity, and photosynthetic characteristics of the Arabica coffee root zone. The entropy weight-TOPSIS method was employed to evaluate the comprehensive benefits. The results showed that FM had the biggest effect on improving soil fertility, microorganisms, and enzyme activities compared with FL and FH. Moreover, compared to CA, CC significantly increased soil organic carbon, organic matter, and total nitrogen content. CC significantly enhanced the activities of soil phosphatase and urease, respectively, by 29.84% and 96.00%, and significantly increased the amount of bacteria, fungi, and actinomycetes by 62.15%, 68.42%, and 46.21%, respectively. The net photosynthetic rate (Pn), transpiration rate (Tr), and stomatal conductance (Gs) of FMCC were significantly higher than those of other treatments. The comprehensive benefit evaluation of the soil environment and photosynthetic characteristics by the entropy weight-TOPSIS method ranked FMCC first. Therefore, FMCC was the optimal coupling mode for fertilizer application and the coffee husk returning method. The findings of this study not only provide scientific guidance for fertilizing Arabica coffee but also clarify the proper approach to returning coffee husk to the field, thereby improving soil ecology and promoting green and efficient production of specialty crops.
Comparison of Evapotranspiration Partitioning and Dual Crop Coefficients of Direct-Seeded and Transplanted Rice in the Poyang Lake Basin, China
Authors: Liu Bo , Hou Jiajia , Ge Hengjun , Liu Meng , Shi Lijie , Li Cheng , Cui Yuanlai
Published: April 2023

Direct-seeded rice (DSR) has received much attention because of its advantages in having low labor costs compared to the traditional transplanted rice (TPR). Investigating the differences in evapotranspiration (ET) partitioning and crop coefficients (Kc) between DSR and TPR is essential in understanding how agricultural water demand is affected by crop rotation. In this study, the water fluxes of two-year (2017–2018) growing seasons were collected from a pair of eddy covariance (EC) towers for DSR and TPR in the Poyang Lake Basin, Southern China. This study aims to compare the seasonal characteristics of the ET components (evaporation, E, and transpiration, T) and dual crop coefficients (basal crop coefficient, Ks·Kcb, and soil/water crop coefficient, Ke) of DSR with those of TPR. The ET values for the 2017 and 2018 growing seasons were 374 mm and 436 mm for the DSR, respectively, and 309 mm and 342 mm for the TPR. The seasonal T/ET values in 2017 and 2018 were 0.40 and 0.46 for the DSR, respectively, and 0.49 and 0.52 for the TPR, indicating that the higher ET values for the DSR can be mostly attributed to E. The DSR had overall higher Kc values than the TPR because of free water evaporation during the initial stage and a higher plant density. Our results enrich the Kc dataset for DSR and have great implications for the sustainable irrigation of the Poyang Lake Basin in the future.
Effects of Marine Residue-Derived Fertilizers on Strawberry Growth, Nutrient Content, Fruit Yield and Quality
Authors: Moloșag Ailin , Pârvulescu Oana Cristina , Ion Violeta Alexandra , Asănică Adrian Constantin , Soane Raluca , Moț Andrei , Dobrin Aurora , Frîncu Mihai , Løes Anne-Kristin , Cabell Joshua , Salifoglou Athanasios , Maroulis Marios , Matsia Sevasti , Bujor Oana Crina , Egri Diana , Dobre Tănase , Bădulescu Liliana Aurelia , Lagunosvchi-Luchian Viorica
Published: April 2023

An outdoor experiment was performed for six months to evaluate the effects of organic fertilizers obtained from marine residual materials on strawberry plants. Three types of organic fertilizers were used, i.e., cod (Gadus morhua) bone powder, common ling (Molva molva) bone powder, and pellets obtained by mixing small cod bone powder and rockweed (Ascophyllum nodosum) residues. A tabletop system for strawberry cultivation was designed, in which two bare-root strawberry plants of cultivar ‘Albion’ were planted in a peat substrate in each pot. Five treatments were applied, i.e., cod bone powder (F1), common ling bone powder (F2), small cod bone powder and rockweed residue pellets (FA), chemical fertilizer (E), and a control (C). The number of leaves and their nutrient content, fruit yield and quality characteristics of the strawberries grown using the organic fertilizers were similar or better than those corresponding to treatments E and C. Organic fertilizers derived from the residues of fish and macroalgae could be a promising alternative to chemical fertilizers in strawberry production.
Dragon Fruit Peel Waste (Hylocereus undatus) as a Potential Ingredient for Reducing Lipid Peroxidation, Dietary Advanced Glycation End Products, and Starch Digestibility in Cookies
Authors: Chumroenvidhayakul Siriwan , Thilavech Thavaree , Abeywardena Mahinda , Adisakwattana Sirichai
Published: April 2023

Excessive consumption of cookies has been linked to harmful health outcomes owing to the presence of refined carbohydrates and heat-induced toxicants including end products of lipid peroxidation and dietary advanced glycation end products (dAGEs). To address this issue, this study explores the addition of dragon fruit peel powder (DFP), which is rich in phytochemicals and dietary fibers, to cookies as a potential solution to mitigate their adverse effects. The results indicate that adding DFP at 1%, 2%, and 5% w/w of raw cookie dough significantly improves the total phenolic and betacyanin contents and antioxidant activity, as evidenced by increased ferric-reducing antioxidant power. DFP incorporation also led to reductions in malondialdehyde and dAGEs (p < 0.05). Furthermore, the starch digestibility, hydrolysis index, and predicted glycemic index were all reduced in the presence of DFP, with the latter estimate being due to the higher content of undigested starch. Incorporating DFP in cookies resulted in significant changes in their physical properties, including texture and color. However, sensory evaluation indicates that the overall acceptability of the cookies was not negatively impacted by the addition of up to 2% DFP, suggesting that it is a viable option for enhancing the nutritional value of cookies without compromising their palatability. These findings suggest that DFP is a sustainable and healthier ingredient that can improve the antioxidant capacity of cookies while also mitigating the harmful effects of heat-induced toxins.
On the Use of Population Data for Training Seasonal Local Models-Based Glucose Predictors: An In Silico Study
Authors: Aslan Antonio , Díez José-Luis , Laguna Sanz Alejandro José , Bondia Jorge
Published: April 2023

Most advanced technologies for the treatment of type 1 diabetes, such as sensor-pump integrated systems or the artificial pancreas, require accurate glucose predictions on a given future time-horizon as a basis for decision-making support systems. Seasonal stochastic models are data-driven algebraic models that use recent history data and periodic trends to accurately estimate time series data, such as glucose concentration in diabetes. These models have been proven to be a good option to provide accurate blood glucose predictions under free-living conditions. These models can cope with patient variability under variable-length time-stamped daily events in supervision and control applications. However, the seasonal-models-based framework usually needs of several months of data per patient to be fed into the system to adequately train a personalized glucose predictor for each patient. In this work, an in silico analysis of the accuracy of prediction is presented, considering the effect of training a glucose predictor with data from a cohort of patients (population) instead of data from a single patient (individual). Feasibility of population data as an input to the model is asserted, and the effect of the dataset size in the determination of the minimum amount of data for a valid training of the models is studied. Results show that glucose predictors trained with population data can provide predictions of similar magnitude as those trained with individualized data. Overall median root mean squared error (RMSE) (including 25% and 75% percentiles) for the predictor trained with population data are {6.96[4.87,8.67], 12.49[7.96,14.23], 19.52[10.62,23.37], 28.79[12.96,34.57], 32.3[16.20,41.59], 28.8[15.13,37.18]} mg/dL, for prediction horizons (PH) of {15,30,60,120,180,240} min, respectively, while the baseline of the individually trained RMSE results are {6.37[5.07,6.70], 11.27[8.35,12.65], 17.44[11.08,20.93], 22.72[14.29,28.19], 28.45[14.79,34.38], 25.58[13.10,36.60]} mg/dL, both training with 16 weeks of data. Results also show that the use of the population approach reduces the required training data by half, without losing any prediction capability.
Factors Associated with Smoking and Smokeless Tobacco Use, Intention to Quit, and the Number of Cigarettes Smoked among Adults with High Blood Pressure in a Rural District of Bangladesh
Authors: Islam Fakir M. Amirul , Williams Joanne
Published: April 2023

The current research is an initial investigation aimed at reporting the factors associated with smoking tobacco, smokeless tobacco (SLT) use, the number of cigarettes smoked, and the intention to quit smoking. A total of 307 adults aged 30 to 75 years with high blood pressure were recruited as part of a cluster RCT from a rural area in Bangladesh. The outcome variables included the number of cigarettes smoked per day, intentions to quit smoking, and SLT use. We used Rasch analysis and regression analysis. A low level of education and older age were associated with smoking tobacco and SLT use, respectively. The 62 smokers smoked 9.6 cigarettes or bidi on average per day, and 54 (87%) knew that smoking was associated with cancer. Overall, 41.6% of farmers compared to 58.9% of employees and 53% of people with no education compared to 75% of people with a higher education intended to quit smoking and SLT use. Our research contributes to the evidence that increasing education increases the intention to quit smoking and identifies population groups that could benefit from targeted public health campaigns. Health education programs are needed to increase motivation to quit smoking, especially among farmers, and to reduce SLT use among women and elderly people.
Quantitative Volumetric Enamel Loss after Orthodontic Debracketing/Debonding and Clean-Up Procedures: A Systematic Review
Authors: Paolone Gaetano , Mandurino Mauro , Baldani Sofia , Paolone Maria Giacinta , Goracci Cecilia , Scolavino Salvatore , Gherlone Enrico , Cantatore Giuseppe , Gastaldi Giorgio
Published: April 2023

Objectives: To conduct a systematic review assessing quantitative enamel loss occurring after orthodontic debonding and clean-up procedures. Materials and Methods: A systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was performed on different databases (Embase, Medline, Scopus, Web of Science) for papers investigating volumetric enamel loss due to bracket and clear aligner attachment debonding and/or clean-up procedures. Studies investigating in vivo and in vitro articles published in the English language until 16 July 2022 were included. The study selection was then performed by two authors who screened the abstracts independently. Results: Of 421 screened abstracts, 41 articles were selected for full-text analysis. Finally, nine studies were included in this review. No in vivo papers were retrieved. In vitro papers investigated volumetric loss caused by the removal of metal brackets (n = 7), ceramic brackets (n = 1), and both (n = 1). The clean-up procedure varied among all investigations. Impressions at baseline and after debonding/clean-up were superimposed, and the volumes were subtracted using different 3D digital analysis software. Among all included studies, the volumetric loss of enamel ranged from 0.02 ± 0.01 mm3 to 0.61 ± 0.51 mm3 per tooth. Conclusions: Debonding and clean-up procedures produce enamel loss. The debonding/clean-up procedure that is able to cause the least enamel volume loss has yet to be identified.
Optimization of Damping in a Semi-Active Car Suspension System with Various Locations of Masses
Authors: Čerškus Aurimas , Ušinskis Vygantas , Šešok Nikolaj , Iljin Igor , Bučinskas Vytautas
Published: April 2023

The key request for a vehicle suspension system is vibration control and decreasing the actual inertia forces. This ensures ride comfort for the crew and influences the fatigue level of the driver and overall driving safety. Implementing semi-active damping control in the vehicle suspension allows for adjusting the damping process in the vehicle for minimum acceleration applied to the seats, driver, and passengers. In order to implement theoretical analysis, we used a mathematical full-car model in Simulink/MATLAB. As the load, we added simulations of various artificially generated road profiles. The damping coefficient of the semi-active suspension system was optimized for maximum comfort level for a driver only. Results from the full-car simulation process deliver a graph of the output accelerations showing kinematic excitation from road deformities under various locations of vehicle load positions.
The Development and Prospects of Autonomous Driving Technology
Authors: Clavijo Miguel , Jiménez Felipe , Naranjo Jose Eugenio
Published: April 2023

Autonomous driving is a topic of great interest for developers, researchers, and even automotive integrators and manufacturers [...]
Spatial and Temporal Variability of Upwelling in the West-Central South China Sea and Its Relationship with the Wind Field
Authors: Shi Jinke , He Hongchang , Fan Donglin , Xiong Yuankang , Xiao Bin , Zhang Jie
Published: April 2023

The west-central South China Sea upwelling event is a critical process that regulates the climate and marine ecosystem in the region. In this study, we used sea surface temperature (SST) satellite data from 2000 to 2018 to analyze the spatial and temporal characteristics of upwelling in the west-central South China Sea and combined the wind field data to investigate the effects of wind direction and speed on upwelling. We divided the upwelling sea area into three regions based on the different shoreline angles along the eastern coast of the South China Peninsula: OU_1, OU_2, and OU_3. Our results showed that the upwelling events occurred mainly from May to September in the OU_1 and OU_2 waters. The empirical orthogonal function (EOF) decomposition of the monthly mean SST moment level field indicated a cyclical interannual variation of upwelling in the west-central South China Sea. The correlation analysis showed that wind direction changes have a significant impact on the upwelling intensity center, with the upwelling intensity center moving towards high latitudes and away from the coast when the wind direction changes from north to east. When the wind direction changes from east to south, the upwelling intensity center moves towards low latitudes and near the coast. The average lag time of upwelling events to the wind field in the central and western South China Sea was 38.9 h, with OU_2 showing a longer response time than the other seas. Our study provides important insights into the mechanisms governing upwelling in the west-central South China Sea, which can effectively promote the rational use of ecological resources and provide a scientific basis for marine ecological protection in the region.
Study on the Change in Vegetation Coverage in Desert Oasis and Its Driving Factors from 1990 to 2020 Based on Google Earth Engine
Authors: Li Xu , Shi Ziyan , Yu Jun , Liang Jiye
Published: April 2023

Fractional Vegetation Cover (FVC) is an important indicator to evaluate the quality of the regional ecological environment. Alar City is a typical desert oasis region. Investigating the spatial and temporal changes in its vegetation cover at different stages is a guide to the ecological balance and sustainable green development of the Tarim River basin. Based on the Google Earth Engine (GEE) cloud platform, this study analyzed the spatial and temporal characteristics and trends of vegetation cover changes in Alar City from 1990 to 2020 using the Hurst index and coefficient of variation. The results show that the spatial distribution of vegetation in the study area in the last 30 years shows a wave-like characteristic with an overall apparent upward trend. The vegetation cover in the study area is predominantly increasing and the spatial distribution shows a phased and regional character. Compared with 1990, there is a significant increase in the area of cultivated land in 2020. Among them, the areas of vegetation growth mainly occur in the basin around the Tarim River. Human activities have weakened the influence of natural factors on FVC. The results of the study suggest that the GEE platform can be an effective tool for permanently monitoring vegetation.
Sizing Methodology of a Fast Charger for Public Service Electric Vehicles Based on Supercapacitors
Authors: Pedrayes Joaquín F. , Melero Manuel G. , Cabanas Manés F. , Quintana Maria F. , Orcajo Gonzalo A. , González Andrés S.
Published: April 2023

In this article, a new methodology for the sizing of a fast-charging station for electric vehicles is presented. The proposed method is applicable to public service vehicles on urban journeys. Its use has been conceived for vehicles equipped with an energy storage system based on supercapacitors (SCs), which are already functional in several countries. The proposed charging station also uses a bank of SCs of variable capacitance. During the study, mathematical expressions will be obtained for the electrical variables involved in vehicle charging: instantaneous current, peak current, charging time, dissipated energy, and the efficiency of energy transference. From these, each of the components of the system will be dimensioned: the capacitance of the charger with its different variable steps, the initial voltage of the charger, and the current smoothing inductor. The proposed charger presents the advantage of allowing energy to be evacuated to the electric vehicle very quickly and with high performance, all without using an external power source or high-power converters. The proposed architecture minimizes the disturbances that, with conventional methods, would appear on the electrical grid, preventing the installation of fast-charging stations at many grid nodes, as is currently the case. Finally, the charger control algorithm is considerably simplified as it only depends on the initial voltage of the vehicle’s accumulator.
Readability Indices Structure and Optimal Features
Authors: Lipovetsky Stan
Published: April 2023

The work considers formal structure and features of the readability indices widely employed in various information and education fields, including theory of communication, cognitive psychology, linguistics, and multiple applications. In spite of the importance and popularity of readability indices in practical research, their intrinsic properties have not yet been sufficiently investigated. This paper aims to fill this gap between the theory and application of these indices by presenting them in a uniform expression which permits analyzing their features and deriving new properties that are useful in practice. Three theorems are proved for relations between the units of a text structure. The general characteristics are illustrated by numerical examples which can be helpful for researchers and practitioners.
Norm of Hilbert Operator’s Commutants
Authors: Roopaei Hadi
Published: April 2023

In this study, we obtain the ℓp-norms of six classes of operators that commute with the infinite Hilbert operators.
Multiscale Homogenization Techniques for TPMS Foam Material for Biomedical Structural Applications
Authors: Pais Ana , Alves Jorge Lino , Jorge Renato Natal , Belinha Jorge
Published: April 2023

Multiscale techniques, namely homogenization, result in significant computational time savings in the analysis of complex structures such as lattice structures, as in many cases it is inefficient to model a periodic structure in full detail in its entire domain. The elastic and plastic properties of two TPMS-based cellular structures, the gyroid, and the primitive surface are studied in this work through numerical homogenization. The study enabled the development of material laws for the homogenized Young’s modulus and homogenized yield stress, which correlated well with experimental data from the literature. It is possible to use the developed material laws to run optimization analyses and develop optimized functionally graded structures for structural applications or reduced stress shielding in bio-applications. Thus, this work presents a study case of a functionally graded optimized femoral stem where it was shown that the porous femoral stem built with Ti-6Al-4V can minimize stress shielding while maintaining the necessary load-bearing capacity. It was shown that the stiffness of cementless femoral stem implant with a graded gyroid foam presents stiffness that is comparable to that of trabecular bone. Moreover, the maximum stress in the implant is lower than the maximum stress in trabecular bone.
Towards a Rapid-Turnaround Low-Depth Unbiased Metagenomics Sequencing Workflow on the Illumina Platforms
Authors: Koh Winston Lian Chye , Poh Si En , Lee Chun Kiat , Chan Tim Hon Man , Yan Gabriel , Kong Kiat Whye , Lau Lalita , Lee Wai Yip Thomas , Cheng Clark , Hoon Shawn , Seow Yiqi
Published: April 2023

Unbiased metagenomic sequencing is conceptually well-suited for first-line diagnosis as all known and unknown infectious entities can be detected, but costs, turnaround time and human background reads in complex biofluids, such as plasma, hinder widespread deployment. Separate preparations of DNA and RNA also increases costs. In this study, we developed a rapid unbiased metagenomics next-generation sequencing (mNGS) workflow with a human background depletion method (HostEL) and a combined DNA/RNA library preparation kit (AmpRE) to address this issue. We enriched and detected bacterial and fungal standards spiked in plasma at physiological levels with low-depth sequencing (<1 million reads) for analytical validation. Clinical validation also showed 93% of plasma samples agreed with the clinical diagnostic test results when the diagnostic qPCR had a Ct < 33. The effect of different sequencing times was evaluated with the 19 h iSeq 100 paired end run, a more clinically palatable simulated iSeq 100 truncated run and the rapid 7 h MiniSeq platform. Our results demonstrate the ability to detect both DNA and RNA pathogens with low-depth sequencing and that iSeq 100 and MiniSeq platforms are compatible with unbiased low-depth metagenomics identification with the HostEL and AmpRE workflow.
Using Contactless Facial Image Recognition Technology to Detect Blood Oxygen Saturation
Authors: Cheng Jui-Chuan , Pan Tzung-Shiarn , Hsiao Wei-Cheng , Lin Wei-Hong , Liu Yan-Liang , Su Te-Jen , Wang Shih-Ming
Published: April 2023

Since the outbreak of COVID-19, as of January 2023, there have been over 670 million cases and more than 6.8 million deaths worldwide. Infections can cause inflammation in the lungs and decrease blood oxygen levels, which can lead to breathing difficulties and endanger life. As the situation continues to escalate, non-contact machines are used to assist patients at home to monitor their blood oxygen levels without encountering others. This paper uses a general network camera to capture the forehead area of a person’s face, using the RPPG (remote photoplethysmography) principle. Then, image signal processing of red and blue light waves is carried out. By utilizing the principle of light reflection, the standard deviation and mean are calculated, and the blood oxygen saturation is computed. Finally, the effect of illuminance on the experimental values is discussed. The experimental results of this paper were compared with a blood oxygen meter certified by the Ministry of Health and Welfare in Taiwan, and the experimental results had only a maximum error of 2%, which is better than the 3% to 5% error rates in other studies The measurement time was only 30 s, which is better than the one minute reported using similar equipment in other studies. Therefore, this paper not only saves equipment expenses but also provides convenience and safety for those who need to monitor their blood oxygen levels at home. Future applications can combine the SpO2 detection software with camera-equipped devices such as smartphones and laptops. The public can detect SpO2 on their own mobile devices, providing a convenient and effective tool for personal health management.
Assessment of Dorsiflexion Ability across Tasks in Persons with Subacute SCI after Combined Locomotor Training and Transcutaneous Spinal Stimulation
Authors: Hope Jasmine M. , Field-Fote Edelle C.
Published: April 2023

In people with spinal cord injury (SCI), transcutaneous spinal stimulation (TSS) has an immediate effect on the ability to dorsiflex the ankle, but persistent effects are not known. Furthermore, TSS has been associated with improved walking, increased volitional muscle activation, and decreased spasticity when combined with locomotor training (LT). In this study, the persistent impact of combined LT and TSS on dorsiflexion during the swing phase of walking and a volitional task in participants with SCI is determined. Ten participants with subacute motor-incomplete SCI received 2 weeks of LT alone (wash-in phase), followed by 2 weeks of either LT + TSS (TSS at 50 Hz) or LT + TSSSham (intervention phase). There was no persistent effect of TSS on dorsiflexion during walking and inconsistent effects on the volitional task. There was a strong positive correlation between the dorsiflexor ability for both tasks. There was a moderate effect of 4 weeks of LT on increased dorsiflexion during the task (d = 0.33) and walking (d = 0.34) and a small effect on spasticity (d = −0.2). Combined LT + TSS did not show persistent effects on dorsiflexion ability in people with SCI. Four weeks of locomotor training was associated with increased dorsiflexion across tasks. Improvements in walking observed with TSS may be due to factors other than improved ankle dorsiflexion.
Escape Survival and Scale Damage Assessment of Red Mullet (Mullus barbatus Linnaeus, 1758) during Bottom Trawling in the Central Mediterranean Sea
Authors: Geraci Michele Luca , Sardo Giacomo , Falsone Fabio , Scannella Danilo , Breen Michael , Fiorentino Fabio , Sala Antonello , Vitale Sergio
Published: April 2023

Stock assessments routinely evaluate the status of commercially harvested species, but seldom account for the possible mortality of released or escaping fish. This study presents a method for estimating the escape survival of the red mullet (Mullus barbatus) from demersal trawling in the Central Mediterranean Sea. Fish escaping from the trawl codend were collected in a detachable cage, which was lined to reduce water flow and protect the sampled fish from further fatigue and injury. Control fish (from an open codend) showed high survival, 94% (87–97%, 95% Confidence Interval), and minimal injuries, while fish escaping through codend meshes had significantly increased injuries and reduced survival, 63% (55–70%). During 7 days of captive monitoring, treatment group mortality was highest in the first 24 h and ceased for both groups within 48 h. Conflicting length-related mortality was observed, where larger treatment fish had a higher probability of dying, while the opposite was observed in the controls. Analysis showed that treatment fish were significantly more injured than control fish, with treatment fish predominantly injured in the head zone. In conclusion, this improved methodology should be repeated to provide accurate escape mortality estimates for the improved stock assessment of the red mullet in the Central Mediterranean.
Systematic Review of Binge Eating Rodent Models for Developing Novel or Repurposing Existing Pharmacotherapies
Authors: Berger Gregory , Corris Joshua D. , Fields Spencer E. , Hao Lihong , Scarpa Lori L. , Bello Nicholas T.
Published: April 2023

Recent advances in developing and screening candidate pharmacotherapies for psychiatric disorders have depended on rodent models. Eating disorders are a set of psychiatric disorders that have traditionally relied on behavioral therapies for effective long-term treatment. However, the clinical use of Lisdexamfatamine for binge eating disorder (BED) has furthered the notion of using pharmacotherapies for treating binge eating pathologies. While there are several binge eating rodent models, there is not a consensus on how to define pharmacological effectiveness within these models. Our purpose is to provide an overview of the potential pharmacotherapies or compounds tested in established rodent models of binge eating behavior. These findings will help provide guidance for determining pharmacological effectiveness for potential novel or repurposed pharmacotherapies.
A Brief Overview of Neutrophils in Neurological Diseases
Authors: Chakraborty Supriya , Tabrizi Zeynab , Bhatt Nairuti Nikhil , Franciosa Sofia Andrea , Bracko Oliver
Published: April 2023

Neutrophils are the most abundant leukocyte in circulation and are the first line of defense after an infection or injury. Neutrophils have a broad spectrum of functions, including phagocytosis of microorganisms, the release of pro-inflammatory cytokines and chemokines, oxidative burst, and the formation of neutrophil extracellular traps. Traditionally, neutrophils were thought to be most important for acute inflammatory responses, with a short half-life and a more static response to infections and injury. However, this view has changed in recent years showing neutrophil heterogeneity and dynamics, indicating a much more regulated and flexible response. Here we will discuss the role of neutrophils in aging and neurological disorders; specifically, we focus on recent data indicating the impact of neutrophils in chronic inflammatory processes and their contribution to neurological diseases. Lastly, we aim to conclude that reactive neutrophils directly contribute to increased vascular inflammation and age-related diseases.
Liposomal DQ in Combination with Copper Inhibits ARID1A Mutant Ovarian Cancer Growth
Authors: Kang Xuejia , Wang Qi , Wu Siqi , Wang Chuanyu , Annaji Manjusha , Huang Chung-Hui , Shen Jianzhong , Chen Pengyu , Babu R. Jayachandra
Published: April 2023

Therapeutic strategies for ARID1A-mutant ovarian cancers are limited. Higher basal reactive oxygen species (ROS) and lower basal glutathione (GSH) empower the aggressive proliferation ability and strong metastatic property of OCCCs, indicated by the increased marker of epithelial-mesenchymal transition (EMT) and serving the immunosuppressive microenvironment. However, the aberrant redox homeostasis also empowers the sensitivity of DQ-Lipo/Cu in a mutant cell line. DQ, a carbamodithioic acid derivative, generates dithiocarbamate (DDC) in response to ROS, and the chelation of Cu and DDC further generates ROS and provides a ROS cascade. Besides, quinone methide (QM) released by DQ targets the vulnerability of GSH; this effect, plus the increase of ROS, destroys the redox homeostasis and causes cancer cell death. Also importantly, the formed Cu(DDC)2 is a potent cytotoxic anti-cancer drug that successfully induces immunogenic cell death (ICD). The synergistic effect of EMT regulation and ICD will contribute to managing cancer metastasis and possible drug resistance. In summary, our DQ-Lipo/Cu shows promising inhibitory effects in cancer proliferation, EMT markers, and “heat” the immune response.
A New Generation of IMiDs as Treatments for Neuroinflammatory and Neurodegenerative Disorders
Authors: Kopp Katherine O. , Greer Margaret E. , Glotfelty Elliot J. , Hsueh Shih-Chang , Tweedie David , Kim Dong Seok , Reale Marcella , Vargesson Neil , Greig Nigel H.
Published: April 2023

The immunomodulatory imide drug (IMiD) class, which includes the founding drug member thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically improved the clinical treatment of specific cancers, such as multiple myeloma, and it combines potent anticancer and anti-inflammatory actions. These actions, in large part, are mediated by IMiD binding to the human protein cereblon that forms a critical component of the E3 ubiquitin ligase complex. This complex ubiquitinates and thereby regulates the levels of multiple endogenous proteins. However, IMiD-cereblon binding modifies cereblon’s normal targeted protein degradation towards a new set of neosubstrates that underlies the favorable pharmacological action of classical IMiDs, but also their adverse actions—in particular, their teratogenicity. The ability of classical IMiDs to reduce the synthesis of key proinflammatory cytokines, especially TNF-α levels, makes them potentially valuable to reposition as drugs to mitigate inflammatory-associated conditions and, particularly, neurological disorders driven by an excessive neuroinflammatory element, as occurs in traumatic brain injury, Alzheimer’s and Parkinson’s diseases, and ischemic stroke. The teratogenic and anticancer actions of classical IMiDs are substantial liabilities for effective drugs in these disorders and can theoretically be dialed out of the drug class. We review a select series of novel IMiDs designed to avoid binding with human cereblon and/or evade degradation of downstream neosubstrates considered to underpin the adverse actions of thalidomide-like drugs. These novel non-classical IMiDs hold potential as new medications for erythema nodosum leprosum (ENL), a painful inflammatory skin condition associated with Hansen’s disease for which thalidomide remains widely used, and, in particular, as a new treatment strategy for neurodegenerative disorders in which neuroinflammation is a key component.
Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies
Authors: Grzeszczak Konrad , Kapczuk Patrycja , Kupnicka Patrycja , Mularczyk Maciej , Kwiatkowski Sebastian , Chlubek Dariusz , Kosik-Bogacka Danuta
Published: April 2023

Background: Pregnancy significantly increases the demand for iron (Fe) in the female body to facilitate maternal blood volume expansion, placental development, and fetal growth. As Fe flux in pregnancy is significantly influenced by the placenta, the aim of this study was to determine the dependencies between the Fe concentration in the placenta, the infant’s morphometric parameters and the woman’s morphological blood parameters in the last trimester. Methods: The study was conducted on 33 women with multiple (dichorionic–diamniotic) pregnancies from whom the placentas were drawn, and their 66 infants, including pairs of monozygotic (n = 23) and mixed-sex twins (n = 10). Fe concentrations were determined based on inductively coupled plasma atomic emission spectroscopy (ICP-OES) using ICAP 7400 Duo, Thermo Scientific. Results: The results of the analysis showed that lower placental Fe concentrations were associated with deteriorated morphometric parameters of infants, including weight and head circumference. Although we found no statistically significant dependencies between Fe concentration in the placenta and the women’s morphological blood parameters, higher Fe concentration in the placenta of mothers supplemented with Fe correlated with better morphometric parameters in infants compared to those whose mothers received no Fe supplementation. Conclusions: The research adds additional knowledge for placental iron-related processes during multiple pregnancies. However, many limitations of the study do not allow detailed conclusions to be assessed, and statistical data should be assessed conservatively.
TCP Transcription Factors in Plant Reproductive Development: Juggling Multiple Roles
Authors: Viola Ivana L. , Gonzalez Daniel H.
Published: April 2023

TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR (TCP) transcription factors (TFs) are plant-specific transcriptional regulators exerting multiple functions in plant growth and development. Ever since one of the founding members of the family was described, encoded by the CYCLOIDEA (CYC) gene from Antirrhinum majus and involved in the regulation of floral symmetry, the role of these TFs in reproductive development was established. Subsequent studies indicated that members of the CYC clade of TCP TFs were important for the evolutionary diversification of flower form in a multitude of species. In addition, more detailed studies of the function of TCPs from other clades revealed roles in different processes related to plant reproductive development, such as the regulation of flowering time, the growth of the inflorescence stem, and the correct growth and development of flower organs. In this review, we summarize the different roles of members of the TCP family during plant reproductive development as well as the molecular networks involved in their action.
Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain
Authors: Shahbazi Ali , Sepehrinezhad Ali , Vahdani Edris , Jamali Raika , Ghasempour Monireh , Massoudian Shirin , Sahab Negah Sajad , Larsen Fin Stolze
Published: April 2023

A common neuropsychiatric complication of advanced liver disease, hepatic encephalopathy (HE), impacts the quality of life and length of hospital stays. There is new evidence that gut microbiota plays a significant role in brain development and cerebral homeostasis. Microbiota metabolites are providing a new avenue of therapeutic options for several neurological-related disorders. For instance, the gut microbiota composition and blood-brain barrier (BBB) integrity are altered in HE in a variety of clinical and experimental studies. Furthermore, probiotics, prebiotics, antibiotics, and fecal microbiota transplantation have been shown to positively affect BBB integrity in disease models that are potentially extendable to HE by targeting gut microbiota. However, the mechanisms that underlie microbiota dysbiosis and its effects on the BBB are still unclear in HE. To this end, the aim of this review was to summarize the clinical and experimental evidence of gut dysbiosis and BBB disruption in HE and a possible mechanism.
Targeted Proteomic Analysis of Patients with Ascending Thoracic Aortic Aneurysm
Authors: Daskalopoulou Aphrodite , Giotaki Sotiria G. , Toli Konstantina , Minia Angeliki , Pliaka Vaia , Alexopoulos Leonidas G. , Deftereos Gerasimos , Iliodromitis Konstantinos , Dimitroulis Dimitrios , Siasos Gerasimos , Verikokos Christos , Iliopoulos Dimitrios
Published: April 2023

Background: There is a need for clinical markers to aid in the detection of individuals at risk of harboring an ascending thoracic aneurysm (ATAA) or developing one in the future. Objectives: To our knowledge, ATAA remains without a specific biomarker. This study aims to identify potential biomarkers for ATAA using targeted proteomic analysis. Methods: In this study, 52 patients were divided into three groups depending on their ascending aorta diameter: 4.0–4.5 cm (N = 23), 4.6–5.0 cm (N = 20), and >5.0 cm (N = 9). A total of 30 controls were in-house populations ethnically matched to cases without known or visible ATAA-related symptoms and with no ATAA familial history. Before the debut of our study, all patients provided medical history and underwent physical examination. Diagnosis was confirmed by echocardiography and angio-computed tomography (CT) scans. Targeted-proteomic analysis was conducted to identify possible biomarkers for the diagnosis of ATAA. Results: A Kruskal–Wallis test revealed that C-C motif chemokine ligand 5 (CCL5), defensin beta 1 (HBD1), intracellular adhesion molecule-1 (ICAM1), interleukin-8 (IL8), tumor necrosis factor alpha (TNFα) and transforming growth factor-beta 1 (TGFB1) expressions are significantly increased in ATAA patients in comparison to control subjects with physiological aorta diameter (p < 0.0001). The receiver-operating characteristic analysis showed that the area under the curve values for CCL5 (0.84), HBD1 (0.83) and ICAM1 (0.83) were superior to that of the other analyzed proteins. Conclusions: CCL5, HBD1 and ICAM1 are very promising biomarkers with satisfying sensitivity and specificity that could be helpful in stratifying risk for the development of ATAA. These biomarkers may assist in the diagnosis and follow-up of patients at risk of developing ATAA. This retrospective study is very encouraging; however, further in-depth studies may be worthwhile to investigate the role of these biomarkers in the pathogenesis of ATAA.
Seismic Performance of Reinforced Concrete Buildings with Joist and Wide-Beam Floors during the 26 November 2019 Albania Earthquake
Authors: Baballëku Markel , Isufi Brisid , Ramos António Pinho
Published: April 2023

Beams with width greater than their depth and depth equal to the depth of the slab (concealed wide beams) are widespread in Reinforced Concrete (RC) buildings in Albania. A large number of RC buildings with wide beams were hit by a strong Mw6.4 earthquake on 26 November 2019. The earthquake hit two of the most densely populated areas in Albania and caused widespread damage to these buildings. This paper aims to provide an updated view on the seismic performance of buildings with wide beams in light of the new field data following the 26 November 2019 Albania earthquake. To this end, a thorough literature review including experimental and field observations from past earthquakes is presented and data from field visits in Albania are described. It was found that damage to the joists and wide beams themselves was limited, even when the buildings suffered significant non-structural or structural damage in other elements as a result of the earthquake. A discussion on the behavior of wide beam–column frames based on nonlinear structural analyses and tests from the literature is presented. Furthermore, the implications of the results of the analysis for the seismic performance of RC buildings are discussed and confronted with observations from the 2019 Albania earthquake. Based on the literature review, further experimental research on wide beams with longer and more realistic span lengths is recommended.