bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review and Meta-Analysis of Human Milk Feeding and Short-Term Growth in Preterm and Very Low Birth Weight Infants
Authors: Suganuma Machiko , Rumbold Alice R , Miller Jacqueline , Chong Yan Fong , Collins Carmel T
Published: May 2021

Human milk (HM) is the gold standard for feeding infants but has been associated with slower growth in preterm infants compared with preterm formula. This systematic review and meta-analysis summarises the post-1990 literature to examine the effect of HM feeding on growth during the neonatal admission of preterm infants with birth weight ≤1500g and/or born ≤28 weeks’ gestation. Medline, PubMed, CINAHL and Scopus were searched, and comparisons grouped as: exclusive human milk (EHM) vs exclusive preterm formula (EPTF), any HM vs EPTF and higher vs lower doses of HM. We selected studies that used fortified HM and compared that with a PTF; studies comparing unfortified HM and term formula were excluded. Experimental and observational studies were pooled separately. The GRADE system was used to evaluate risk of bias and certainty of evidence. Forty-four studies were included with 37 (n =9,963 infants) included in the meta-analyses. In general, due to poor quality studies, evidence of the effect of any HM feeds or higher versus lower doses of HM was inconclusive. There was a possible effect that lower doses of HM compared with higher doses of HM improved weight gain during the hospital admission, and separately, a possible effect of increased head circumference growth in infants fed EPTF vs any HM. The clinical significance of this is unclear. There was insufficient evidence to determine the effects of an exclusive HM diet on any outcomes.
A Survey of Current Resources to Study lncRNA-protein Interactions.
Authors: Philip Melcy , Chen Tyrone , Tyagi Sonika
Published: May 2021

Phenotypes are driven by regulated gene expression, which in turn are mediated by complex interactions between diverse biological molecules. Protein-DNA interactions such as histone and transcription factor binding are well studied, along with RNA-RNA interactions in short RNA silencing of genes. In contrast, lncRNA-protein interaction (LPI) mechanisms are comparatively unknown, likely driven by the difficulties in studying LPI. However, LPI are emerging as key interactions in epigenetic mechanism, playing a role in development and disease. Their importance is further highlighted by their conservation across kingdoms. Hence, interest in LPI research is increasing. We therefore review the current state of the art in lncRNA-protein interactions. We specifically surveyed recent computational methods and databases which researchers can exploit for LPI investigation. We discovered that algorithm development is heavily reliant on a few generic databases containing curated LPI information. We show that early methods predict LPI using molecular docking, have limited scope and are slow, creating a data processing bottleneck. Recently, machine learning has become the strategy of choice in LPI prediction, likely due to the rapid growth in machine learning infrastructure and expertise. While many of these methods have notable limitations, machine learning is expected to be the basis of modern LPI prediction algorithms.
Novel Vorinostat Analogues with Improved HDAC Inhibition, Stronger Cytotoxic Effect and Higher Selectivity Against Leukemias and Lymphomas
Authors: Bieszczad Bartosz , Garbicz Damian , Świtalska Marta , Dudek Marta K. , Warszycki Dawid , Wietrzyk Joanna , Grzesiuk Elżbieta , Mieczkowski Adam
Published: May 2021

Histone deacetylase (HDAC) inhibitors are class of drugs used in the cancer treatment. Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in lymphomas treatment. In Vorinostat, we replaced the hydrophobic phenyl group with various tricyclic ‘caps’ possessing a central, eight-membered, heterocyclic ring, and investigated the HDAC activity and cytotoxic effect on the cancer and normal cell lines. We found that three out of the 19 compounds, based on dibenzo[b,f]azocin-6(5H)-one, 11,12-dihydrodibenzo[b,f]azocin-6(5H)-one and benzo[b]naphtho[2,3-f][1,5]diazocine-6,14(5H,13H)-dione scaffolds, showed better HDACs inhibition than the referenced Vorinostat. In leukemic cell line MV4-11 and in lymphoma cell line – Daudi three compounds showed lower IC50 values than Vorinostat. These compounds had higher activity and selectivity against MV4-11 and Daudi cell lines than reference Vorinostat. We also observed a strong correlation between HDACs inhibition and the cytotoxic effect. Cell lines derived from solid tumors: A549 (lung carcinoma) and MCF-7 (breast adenocarcinoma) as well as reference Balb/3T3 (normal murine fibroblasts) were less susceptible to compounds tested. Developed derivatives show superior properties than Vorinostat, thus they are applicable as selective agents for leukemia and lymphoma treatment.
Shared Data Set for Free-Text Keystroke Dynamics Authentication Algorithms
Authors: Iapa Augustin-Catalin , Cretu Vladimir-Ioan
Published: May 2021

Identifying or authenticating a computer user are necessary steps to keep systems secure on the network and to prevent fraudulent users from accessing accounts. Keystroke dynamics authentication can be used as an additional authentication method. Keystroke dynamics involves in-depth analysis of how you type on the keyboard, analysis of how long a key is pressed or the time between two consecutive keys. This field has seen a continuous growth in scientific research. In the last five years alone, about 10,000 scientific researches in this field have been published. One of the main problems facing researchers is the small number of public data sets that include how users type on the keyboard. This paper aims to provide researchers with a data set that includes how to type free text on the keyboard by 80 users. The data were collected in a single session via a web platform. The dataset contains 410,633 key-events collected in a total time interval of almost 24 hours. In similar research, most datasets are with texts written by users in English. The language in which the users wrote for this research is Romanian. This paper also provides an extensive analysis of the data set collected and presents relevant information for the analysis of the data set in future research.
Temperature Effect on Permeate Water in Batch Electrodialysis Reversal
Authors: Dévora-Isiordia Germán Eduardo , Ayala-Espinoza Alejandra , Lares-Rangel Luis Alberto
Published: May 2021

Currently, a large part of the wells for agricultural use located in the state of Sonora are overexploited, which generates a high degree of saline intrusion and abandonment by nearby communities. In this paper the temperature effect on the final concentration of permeate water was evaluated through voltage and intel concentration variations in a batch electrodialysis reversal process (EDR), in order to identify optimal operating conditions with emphasis on the reduction of energy consumption and cost of desalinated water. Thirty-six samples were prepared: eighteen 2,000 mg/L total dissolved solids (TDS) samples and eighteen 5,000 mg/L TDS samples; brackish well water of 639 mg/L TDS and synthetic salt were mixed to obtain those concentrations. 3 different temperatures (25, 30, 35 °C) and 2 different voltages (10 and 20 V) were tested for each sample. The best salt removal occurred in the 20 V arrays, with 18.34% higher removal for 2,000 mg/L TDS experiments and 25.05% for 5,000 mg/L experiments (average between the 25 to 35 °C tests). Temperature positively affected EDR, especially in the experiments at 10 V voltage, where increasing 10 °C increased its efficiency by 10.83% and 24.69% for 2,000 and 5,000 mg/L TDS, respectively. Energy consumption was lower with increasing temperature (35 °C), as it decreased by 1.405% and 1.613% for 2,000 and 5,000 mg/L TDS concentrations, respectively (average between 10 and 20 V tests), decreasing the cost per m3 of water.
A Tale of Two Metrics: The EPA Risk Quotient Approach versus the Delay in Population Growth Index for Determination of Pesticide Risk to Aquatic Species
Authors: Stark John D. , Banks John E.
Published: May 2021

The risk that two closely related insecticides, spinetoram and spinosad, posed to three Cladoceran species, Ceriodaphnia dubia, Daphnia pulex, and D. magna was determined using two approaches, the USEPA Risk Quotient method and the Delay in Population Growth Index (DPGI). Results of the RQ method showed that spinetoram posed a risk to all three species, but spinosad posed a risk only to C. dubia. The DPGI analysis showed that exposure to spinetoram resulted in populations of all three species being delayed > 3 generation times. Exposure to the LC50 and the lower 95% CL resulted in delayed populations while exposure to the upper 95% CL concentration of spinetoram resulted in no recovery of any of the three species over the course of the modeling exercise (88 d). Exposure to the lower and upper 95% Cl and the LC50 of spinosad resulted in C. dubia populations being delayed > 3 generations. D. pulex populations were not negatively affected after exposure to spinosad. D. magna populations were delayed > 3 generations, but only after exposure to the upper 95% Cl of spinosad. These results illustrate that although the EPA risk quotient method indicated that spinetoram posed a risk to all three species and that spinosad only posed a risk to C. dubia, the DPGI showed that D. magna would be negatively affected by spinosad and none of the three species would recover after exposure to the upper 95% CL of spinetoram. Because the DPGI uses the 95% Cl as well as the LC50 in its calculation and produces a measure of population growth and recovery or lack thereof, it provides more detailed information in terms of the potential risk of pesticides to populations than the RQ method.
Genomic Assessment of Stenotrophomonas Indicatrix for Improved Sunflower Plant
Authors: Adeleke Bartholomew Saanu , Ayangbenro Ayansina Segun , Babalola Olubukola Oluranti
Published: May 2021

Plant growth-promotion screening and genome analysis of Stenotrophomonas indicatrix BOVIS40 were presented in this study. The genomic information reveals various genes underlining plant growth promotion and resistance to environmental stressors. The genome of S. indicatrix BOVIS40 harbors genes involved in the degradation and biotransformation of organic molecules. Also, other genes involved in biofilm production, chemotaxis, and flagellation that facilitate bacterial colonization in the root endosphere and phytohormone genes that modulate root development and stress response in plants were detected in strain BOVIS40. IAA activity of the bacterial strain may be a factor responsible for root formation. Nevertheless, the results highlighted here provide insights into the genomic functions of S. indicatrix and which can be explored in agricultural management. Hence, a measurable approach to the S. indicatrix lifestyle can strategically provide several opportunities in their use as bioinoculants in developing environmentally friendly agriculture sustainably.
Drilling of a Bidirectional Jute Fibre and Cork-Reinforced Polymer Biosandwich Structure: ANN and RSM approaches for Modelling and Optimization
Authors: Tabet Zohir , Belaadi Ahmed , Boumaaza Messaouda , Bourchak Mostefa
Published: May 2021

The present study examined the effects of drilling parameters such as spindle speed (N), feed rate (f), diameter of the tools (d) and drill geometry such as twist drills (HSS-TiN) and brad & spur drills (BSD) used on delamination damage in a biosandwich structure consisting of an epoxy matrix reinforced with bidirectional jute fibres and cork (JFCE). Response surface methodology (RSM) and artificial neural networks (ANNs) were exploited to evaluate the influence and interaction of the cutting parameters on the delamination factor (Fd) at the output during drilling. In addition, several optimization methods, such as desirability-based RSM, the genetic algorithm (GA) and the fmincon function, were applied to validate the optimal combination of cutting parameters (f, N and d) in the structures studied in biosandwiches during this research. According to the experimental results, severe damage was indeed observed with the BSD tool (Fd = 1.684) compared to the HSS-TiN tool (Fd = 1.555) for the same cutting conditions. To obtain the minimum Fd, the optimum conditions obtained by GA were respectively 1397.54 rev/min, 51.162 mm/min and 5.981 mm for HSS-TiN for f, N and d.
Minimally Invasive Myxoma Resection: A Single-center 5 Years’ Experience
Authors: Lu Feng , Yang Xin , Xu Jian-Jun , Wu Yong-Bing , Zhu Shu-Qiang , Chen Shi-Wei , Zou Hong-Peng , Nie Rui-Zhi , Li Ze-Long , Long Xiang
Published: May 2021

BackgroundIncreasing demand for minimally invasive myxoma resection. This study aimed to investigate the safety and feasibility of minimally invasive myxoma resection. MethodsThis is a retrospective study, we collected information on 95 patients who underwent myxoma resection from January 2016 to December 2020. According to the operative approach, they were divided into a minimally invasive myxoma resection(Mini-MR) group (n=30) and a sternotomy myxoma resection(SMR) group (n=65), we compared the intraoperative and postoperative data between the two groups. ResultsPostoperative ventilator assisted time, CSICU time and postoperative hospital stay of Mini-AVR were shorter than SAVR [(13.05 ± 4.98) VS (17.07 ± 9.52)h ;(1.73 ± 0.29) VS (2.27 ± 1.53)d; (6.20 ± 1.50) VS (9.48 ± 3.37)d], the difference was statistically significant (P <0.05). Mini-AVR has lower postoperative drainage and blood transfusion rate of the first 24 h compared with SAVR [(38.93 ± 69.62) VS (178.25 ± 153.06)ml; 26.6% VS 63.1%], the differences were statistically significant (P <0.05). Conclusion﻿Mini-MR has the advantages of less CSICU stay time, less ventilator time, less postoperative drainage the first 24h, less blood transfusion, fewer postoperative hospital stays, and faster recovery. Mini-MR is a safe and feasible surgical procedure for the resection of myxoma.
Alterations in Sphingolipid Composition and Mitochondrial Complex I Deficiency Represent Synergistic Therapeutic Vulnerabilities Linked to Vincristine Resistance
Authors: Fisher-Wellman Kelsey H. , Hagen James T , Kassai Miki , Kao Li-Pin , Nelson Margaret , McLaughlin Kelsey , Coalson Hannah , Fox Todd , Tan Su-Fern , Feith David , Kester Mark , Loughran Thomas , Claxton David , Cabot Myles
Published: May 2021

Background: Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actions are often supplanted by resistance. In the present work we utilized HL-60 human leukemia cells and a VCR-resistant counterpart, HL-60/VCR cells, to determine potential interplay between SL metabolism and mitochondrial bioenergetics supportive of VCR resistance. Methods: Cellular SL alterations were assessed via a combination of enzyme immunoblot analysis and lipidomics. Mitochondrial function was evaluated in intact cells, permeabilized cells and isolated mitochondria using a comprehensive diagnostic assay system designed to directly interrogate oxidative phosphorylation (OXPHOS) kinetics. Informed by SL and bioenergetic readouts, experiments were designed to assess the therapeutic efficacy of co-targeting SL metabolism and mitochondrial flux to combat VCR resistance. Results: Relative to wild-type cells, HL-60/VCR presented with global alterations in SL composition, typified by upregulated expression of sphingosine kinase (SPHK1), which catalyzes formation of sphingosine 1-phosphate (S1P), glucosylceramide synthase (GCS), which catalyzes formation of glucosylceramides (GC), and acid ceramidase, responsible for ceramide hydrolysis. In support of these changes, VCR resistance was also characterized by increases in S1P, several molecular species of ceramide and GC, and changes in sphingomyelin (SM) molecular species. With respect to mitochondria, despite increased basal respiration in HL-60/VCR cells, direct interrogation of the mitochondrial network revealed intrinsic respiratory complex insufficiency, largely localized to complex I (CI). Importantly, forced ceramide accumulation in wild-type cells phenocopied the respiratory insufficiency observed in HL-60/VCR, and co-targeting SL metabolism and CI induced synergistic cytotoxicity in HL-60/VCR. Conclusions: Together, these data underscore the intimate connection between cellular sphingolipids and mitochondrial metabolism and suggest that pharmacological intervention across both pathways may represent a novel treatment strategy against VCR resistance.
Development of Metal-Based Drugs and Application in Clinical Treatment
Authors: Shao Yi Ming , Sharavyn Bold , Huang Ping , Naranmandura Hua , Wang Qian Qian
Published: May 2021

Metals occur naturally in soil and many kinds of rocks, particularly in minerals and ores,
which also play a vital role in living systems such as plants and animals. Over the large time scale,
metal evolution from toxins to drugs has achieved a milestone mean in medicine. Currently, a few
metal-based drugs (i.e., metallodrugs) have been used in the clinic to treat patients with different
medical conditions, making exciting new developments in anticancer therapeutics (e.g., arsenic trioxide
and cisplatin) that quickly move into focus. Moreover, a thorough understanding of the properties
and effects of metals on the human body could improve the development and innovation of
metal-based drugs. In this review, we have comprehensively described the discovery and development
of metal-based anticancer drugs, as well as their side effects in clinical treatment. Although
metallodrugs have shown promising outcomes in the treatment of cancers, further investigation is
needed to optimize their side effect for broader applications.
ABOUT IMPROVEMENT OF MEASURES TO COUNTER TERRORISTS USE NEW TECHNOLOGIES
Authors:   A.M. Abdulatipov Dagestan State University, Abdulatipov A.M.
Published: May 2021

The article is devoted to the study of measures to counter terrorists use achievement of science and new technologies for criminal purposes. The article reflects the technologies that represent the most significant terrorist threat. It also analyzes and summarizes the existing experience of countering the use of these technologies for terrorist attacks. The article also highlights the main activities aimed at countering cyberterrorism at the international and Federal levels, as well as the most effective forms of prevention of cyberterrorism in the region. Based on the study, the author made a number of conclusions and proposals of theoretical and practical importance.
GOVERNMENT OF THE RUSSIAN FEDERATION: ISSUES OF CONTINUITY, RECEPTION AND REFORM AT THE PRESENT STAGE
Authors:   S.A. Saibulaeva Dagestan State University, Saibulaeva S.A.
Published: May 2021

The article discusses the controversial issues of formation and functioning of the Supreme Executive body of the Russian Federation. It is shown that the modern Russian state system continues to be reformed under the influence of continuity and/or reception of political and legal institutions, and their subsequent transformation. It is noted, that the essence of such a reform is to introduce progressive (rational) legal norms into the national legal system that harmonize issues of governance and state structure. The article systematizes the types and methods of state-legal control over the formation and activities of the Government of the Russian Federation within the framework of the functioning of the constitutional principle of separation of powers and the system of checks and balances. The article analyzes the impact of modern constitutional innovations on the Russian state legal system and the expected legal consequences.
ACTUAL PROBLEMS OF TAX ADMINISTRATION
Authors:   A.Z. Arslanbekova Dagestan State University, Arslanbekova A.Z. , Mustafaev R.E. ,   Dagestan State University
Published: May 2021

The problem of tax administration is reaching a new level. The scientific novelty lies in the fact that the trends outlined in the article allow us to note the high role of information technologies in improving the efficiency of tax administration. The authors draw attention to important theoretical and practical problems of tax administration. The directions of improving the theory and practice of tax administration are determined. When writing the article, the following research methods were used: logical, formal-legal, method of legal modeling and analysis. In conclusion, it is concluded that the reference to the normative legal acts that make up the tax legislation in its entirety allows us to note its inefficiency and the need for further improvement. The analysis of the basic provisions of the strategy of the Federal tax service allows us to note the vector of development of tax monitoring technologies through the introduction of IT systems, the effectiveness of which will be determined by the ability to overcome tax risks.
Marketing digital como recurso táctico para las microempresas
Authors:   Universidad Autónoma del Caribe, Urango de la Rosa Yajaira
Published: May 2021

Tomando en cuenta la importancia estrategia organizacional del marketing digital en la actualidad, se propone analizar el marketing digital como recurso táctico para microempresas, a los fines de disen?ar un plan que haga posible la identificación y caracterización de las estrategias necesarias para poder desarrollarlo, utilizando un enfoque post positivista, un paradigma de tipo cualitativo, documental y disen?o bibliogra?fico, incluidas revisiones literarias, recopilacio?n de informacio?n y determinacio?n y clasificacio?n de objetivos. Es asi? como a trave?s de los hallazgos más importantes se pudo evidenciar la importancia que ha adquirido el sector de microempresas, así? como la pertinencia que tiene la generación de un plan que conciba un fuerte componente digital, para apalancar el funcionamiento operativo de este tipo de organización.
НОВАЯ МИКРОСХЕМА ПРИЕМОПЕРЕДАТЧИКА ДЛЯ ИНТЕРФЕЙСА RS 485 КОМПАНИИ АО «ПКК МИЛАНДР»
Authors: Колесников Д. , Сухотерин Е. , Богданов В. , Павлюк Ю. , Тучин А.
Published: May 2021

Рассмотрена новая микросхема приемопередатчика для интерфейса RS 485 компании АО «ПКК Миландр» – К5559ИН86SI. Приведена информация о характеристиках и особенностях данной микросхемы.
Major element chemistry of the march-april (1982) Chichon volcanic
Authors: Martin-Del Pozzo A. L. , Romero M. V. H.
Published: May 2021

El análisis químico de elementos mayores y los estudios petrográficos de los productos eruptivos del volcán Chichón, de marzo-abril, mostraron un alto porcentaje de material juvenil. Las muestras en general, fueron clasificadas como andesitas ricas en álcalis con plagioclasa zoneada, hornblenda, augita y biotita, como minerales principales. Los diagramas K20-Si02, (MgO-FeO+ Fe203) y AFM sugieren un origen calci-alcalino-shoshonítico que puede estar relacionado con la subducción y que no parece estar ligado a los volcanes de los Tuxtlas. Un alto grado de contaminación por evaporitas es reflejado en el alto porcentaje de alcalis y calcio, xenolitos de carbonatos y cristales de anhidrita en la ceniza. Existe un aumento aparente en el porcentaje de sílice durante cada erupción.
Simulation of the annual cycle of climate with a thermodynamic numerical model
Authors: Adem J.
Published: May 2021

Se presenta un modelo hemisférico numérico termodinámico en el que el ciclo anual del albedo de superficie se genera internamente, junto con la temperatura troposferica media, la temperatura en la superficie de los continentes, y la radiación de onda corta y larga. El modelo también incluye como variables las anomalias de la temperatura de la superficie de los oceanos, la evaporaci6n en la superficie, el calor sensible cedido por la superficie a la atm6sfera, el calor de condensaci6n de vapor de agua en las nubes, la extension horizontal de la nubosidad y la componente horizontal del viento. Los valores calculados del ciclo anual del albedo de superficie, de la temperatura a los 700 mb y de las componentes de la radiaci6n muestran, en general, buena concordancia con los valores observados.
Modelo preliminar del régimen térmico conductivo en la Caldera de Los Humeros, Puebla
Authors: Prol R.M. , Gonzalez-Moran Tomás
Published: May 2021

Las características geológicas de la Caldera de Los Humeros (19º42'N, 97°25'W) sugieren que el mecanismo de transmisión de calor es en su mayor parte de tipo conductivo. Tomando en cuenta este mecanismo y los datos geológicos y geofísicos disponibles, es posible calcular el campo de temperaturas bajo la Caldera. El procedimiento seguido en este trabajo consiste en resolver la ecuación de conducción de calor con el método de Diferencias Finitas (D-F). La estructura interna se obtuvo con los datos geológicos y geofísicos del área. Los resultados obtenidos del modelo presentado permiten estimar la zona de máxima influencia que tenga la temperatura necesaria para la producción de energía geotérmica a profundidad costeable.
Preliminary experiments on the climatic effect of an increase of the atmospheric CO2 , using a thermodynamic mode
Authors: Adem J. , Garduño R.
Published: May 2021

Para calcular el calentamiento debido a una duplicación del C02 atmosférico, se aplica un modelo termodinámico que incluye el ciclo anual del clima y una capa oceánica mezclada. El modelo usa un enfoque nuevo y simplificado para el tratamiento de las variaciones en el calentamiento introducido al incrementar el C02 atmosférico. El aumento promedio anual calculado en el hemisferio norte es de .7°C, con valores de .8ºC en primavera y verano y .6°C en invierno y otoño. Sin embargo, cuando las variaciones del calentamiento distinto de radiación (transporte vertical de calor sensible, evaporación en la superficie y condensación de vapor de agua en las nubes) se desprecian, el promedio anual del aumento calculado es l.4°C. Se demuestra que la capa oceánica mezclada tiene un papel importante en los cálculos.
Two-stream computations of water body reflectances
Authors: Lemus L. , Gay C. , Camacho S.
Published: May 2021

Se utiliza el método de dos haces para resolver la ecuación de transferencia de radiaci6n. Se calculan la intensidad hacia adelante y la retro-intensidad, así como la reflectancia de un cuerpo de agua. El método de dos haces sé compara con otro y se presentan los resultados de una aplicación práctica.
Geopolitical Imagination: Ideology and Utopia in Post-Soviet Russia
Authors: Neumann Iver
Published: May 2021

Iver Neumann, director of the Fritjof Nansen Institute, reviews Geopolitical Imagination: Ideology and Utopia in Post-Soviet Russia by Mikhail Suslov.
Tourism and Travel during the Cold War: Negotiating Tourist Experiences across the Iron Curtain
Authors: Ubbesen Thomas
Published: May 2021

Thomas Ubbesen reviews Tourism and Travel during the Cold War: Negotiating Tourist Experiences across the Iron Curtain, edited by Sune Bechmann Pedersen and Christian Noack.
Analisis Performansi Algoritma Linear Regression dengan Generalized Linear Model untuk Prediksi Penjualan pada Usaha Mikra, Kecil, dan Menengah
Authors: Hamdanah Fitria Habibatul , Fitrianah Devi
Published: May 2021

Penjualan merupakan syarat mutlak kelangsungan suatu usaha, karena dengan penjualan maka akan didapatkan keuntungan. Metode Linear Regression dan Generalized Linear Model merupakan metode pendekatan yang didukung dengan perhitungan RSME. RMSE (Root Mean Square Error) berfungsi untuk mendapatkan besaran tingkat kesalahan dari hasil prediksi, dimana semakin kecil (mendekati 0) nilai RMSE maka semakin akurat nilai prediksinya. Pada setiap Usaha Mikro Kecil Menengah (UMKM) aktivitas transaksi dan pelayanan terhadap konsumen setiap harinya semakin lama semakin meningkat, sehingga tanpa disadari hal ini dapat menimbulkan tumpukan data yang semakin membesar. UMKM biasanya mengeluarkan beberapa item berbeda untuk ditawarkan ke pasar dengan harga yang berbeda, namun tidak semua barang banyak peminatnya. Keberhasilan penjualannya menentukan keberlanjutan untuk umkm itu sendiri. Pada penelitian ini akan dibandingkan penggunaan algoritma Linear Regression dengan Generalized Linear Model yang diimplementasikan pada data penjualan yang sudah diinputkan sebelumnya guna menghasilkan prediksi penjualan barang untuk tahun berikutnya. Hasil perhitungan menunjukkan bahwa algoritma Linear Regression dengan nilai RSME, MSE,MAPE sebesar 1,983; 3,933; dan 1,518 sedangkan hasil dari algoritma Generalized Linear Model dengan nilai RSME, MSE, MAPE sebesar 4,827; 23,295; dan 3,882. Berdasarkan perhitungan prediksi oleh algoritma Linear Regression dan Generalized Linear Model dapat disimpulkan bahwa nilai RSME pada algoritma Linear Regression menunjukkan perhitungan paling baik dikarenakan nilai RSME paling kecil.
Entrevista
Authors:   Centro de Medicina Desportiva do Porto, Cardoso-Marinho Beatriz
Published: May 2021

...O que mais me motiva atualmente é a promoção científica dos meus colegas, com vista ao seu enriquecimento profissional e individual e, consequentemente, a valorização da nossa especialidade em Portugal. ... A Medicina Desportiva em Portugal está em evolução e depende da contribuição de todos para colocar esta especialidade ao serviço da população. Atualmente, o custo de inatividade física em Portugal traduz-se em 900 milhões de euros. Ora, existe carência desta especialidade também na prescrição de exercício, seja à população geral, seja a populações específicas, nomeadamente em fatores de risco cardiovasculares...
FMUP - May 2021 (summaries and comments of papers)
Authors:   Hospital Senhora da Oliveira – Guimarães, Freitas Cunha Ana Mafalda , Maia Ribeiro Ana Sofia ,   Hospital de Braga
Published: May 2021

summary and comment - Resurgence of sports in the wake of COVID-19: cardiac considerations in competitive athletes
Surgical management and outcome of dogs with primary spontaneous pneumothorax: 110 cases (2009–2019)
Authors: Dickson Rachel , Scharf Valery F. , Michael Aleisha E. , Walker Meagan , Thomson Chris , Grimes Janet , Singh Ameet , Oblak Michelle , Brisson Brigitte , Case J. Brad
Published: May 2021

OBJECTIVE

To describe surgical management and associated outcomes for dogs with primary spontaneous pneumothorax.

ANIMALS

110 client-owned dogs with primary spontaneous pneumothorax that underwent surgical management.

PROCEDURES

Medical records at 7 veterinary teaching hospitals were reviewed. Data collected included signalment, history, clinical signs, radiographic and CT findings, surgical methods, intraoperative and postoperative complications, outcomes, and histopathologic findings. Follow-up information was obtained by contacting the referring veterinarian or owner.

RESULTS

110 dogs were included, with a median follow-up time of 508 days (range, 3 to 2,377 days). Ninety-nine (90%) dogs underwent median sternotomy, 9 (8%) underwent intercostal thoracotomy, and 2 (2%) underwent thoracoscopy as the sole intervention. Bullous lesions were most commonly found in the left cranial lung lobe (51/156 [33%] lesions) and right cranial lung lobe (37/156 [24%] lesions). Of the 100 dogs followed up for > 30 days, 13 (13%) had a recurrence of pneumothorax, with median time between surgery and recurrence of 9 days. Recurrence was significantly more likely to occur ≤ 30 days after surgery, compared with > 30 days after surgery. Recurrence > 30 days after surgery was rare (3 [3%]). No risk factors for recurrence were identified.

CONCLUSIONS AND CLINICAL RELEVANCE

Lung lobectomy via median sternotomy resulted in resolution of pneumothorax in most dogs with primary spontaneous pneumothorax. Recurrence of pneumothorax was most common in the immediate postoperative period, which may have reflected failure to identify lesions during the initial thoracic exploration, rather than development of additional bullae.
Study of the solubilisation process of bacterial model membranes induced by DDAO
Authors: Želinská K. , Gallová J.
Published: May 2021

Solubilisation of two bacterial model membranes induced by N,N-dimethyl-1-dodecanamine-N-oxide (DDAO) was studied. The first model membrane consisted of a mixture of palmitoyloleoylphosphatidylethanolamine (POPE) and palmitoyloleoylphosphatidylglycerol (POPG) in a molar ratio 0.6:0.4 mol/mol, and a second model membrane was enriched with tetraoleoylcardiolipin (TOCL) with a composition POPE-POPG-TOCL = 0.67:0.23:0.1 mol/mol/mol. Solubilisation of these model membranes was studied by static light scattering (nephelometry). Effective ratio Re (the amount of DDAO integrated into the bilayer to the amount of lipid) at different steps of the solubilisation process was determined. The molar partition coefficient of DDAO was calculated – in case of the POPE-POPG membrane, Kp = 5,300 ± 400, for the POPE-POPG-TOCL membrane, Kp = 6,500 ± 500.
Eco-Fashion Designing to Ensure Corporate Social Responsibility within the Supply Chain in Fashion Industry
Authors: Jutidamrongphan Warangkana , Rahman Md Ahbabur , Hossain Tareq , Khatun Syeda Abida , Lamas Wendell de Queiróz
Published: May 2021

Fashion is a widespread cultural phenomenon which supports cultural attitudes and proposes new ways of acting. This study considers how ecological goals can be applied in the fashion industry through an awareness of its effects on the environment with the aim of conducting the process of designing and manufacturing fashion garments. To understand this needs practically, this study investigates on few industries in Hatyai municipality (Thailand) for knowing their practice on eco-fashion approach to support MSW management properly. The study adopts as its methodology a systematic review of relevant literature covering the twin problems of the degradation of the environment and the shortage of natural resources currently caused by the fashion-garment industry, in search of feasible solutions centred on the concept of eco-fashion. The study also addresses how the concept of ecological clothing can generate a new mentality among consumers. The study identifies concepts, techniques and processes which can economically be applied in producing fashion garments from a more ecologically sound starting point. This paper also sheds light on how corporate social responsibility (CSR) can be practiced within the fashion supply chain. This study contributes to the existing literature by assisting the understanding of the current situation of waste in the fashion-garment industry and the methods necessary to ensure eco-fashion designing and a responsible fashion supply chain.
Renal Recovery in Critically Ill Adult Patients Treated With Veno-Venous or Veno-Arterial Extra Corporeal Membrane Oxygenation: A Retrospective Cohort Analysis
Authors: Thyagarajan Braghadheeswar , Murea Mariana , Jones Deanna N. , Saha Amit K. , Russell Gregory B. , Khanna Ashish K.
Published: May 2021

Introduction

Patients on extracorporeal membrane oxygenator (ECMO) therapy are critically ill and often develop acute kidney injury (AKI) during hospitalisation. Little is known about the association of exposure to and the effect of the type of ECMO and extent of renal recovery after AKI development.

Aim of the study

In patients who developed AKI, renal recovery was characterised as complete, partial or dialysis-dependent at the time of hospital discharge in both the Veno-Arterial (VA) and Veno-Venous (VV) ECMO treatment groups.

Material and methods

The study consisted of a single-centre retrospective cohort that includes all adult patients (n=125) who received ECMO treatment at a tertiary academic medical centre between 2015 to 2019. Data on demographics, type of ECMO circuit, comorbidities, exposure to nephrotoxic factors and receipt of renal replacement therapy (RRT) were collected as a part of the analysis. Acute Kidney Injury Network (AKIN) criteria were used for the diagnosis and classification of AKI. Group differences were assessed using Fisher’s exact tests for categorical data and independent t-tests for continuous outcomes.

Results

Sixty-four patients received VA ECMO, and 58 received VV ECMO. AKI developed in 58(91%) in the VA ECMO group and 51 (88%) in the VV ECMO group (p=0.77). RRT was prescribed in significantly higher numbers in the VV group 38 (75%) compared to the VA group 27 (47%) (p=0.0035). At the time of discharge, AKI recovery rate in the VA group consisted of 15 (26%) complete recovery and 5 (9%) partial recovery; 1 (2%) remained dialysis-dependent. In the VV group, 22 (43%) had complete recovery (p=0.07), 3(6%) had partial recovery (p=0.72), and 1 (2%) was dialysis-dependent (p>0.99). In-hospital mortality was 64% in the VA group and 49% in the VV group (p=0.13).

Conclusions

Renal outcomes in critically ill patients who develop AKI are not associated with the type of ECMO used. This serves as preliminary data for future studies in the area.
Prevalence of Depression, Anxiety and Stress among Patients Discharged from Critical Care Units
Authors: Saeidi Mohammad , Safaei Alireza , Sadat Zohreh , Abbasi Parisa , Sarcheshmeh Masoumeh Sadat Mousavi , Dehghani Fariba , Tahrekhani Mehran , Abdi Mohammad
Published: May 2021

Introduction

The widespread use of advanced technology and invasive intervention creates many psychological problems for hospitalized patients; it is especially common in critical care units.

Methods

This cross-sectional study was conducted on 310 patients hospitalized in critical care units, using a non-probability sampling method. Data were collected using depression, anxiety, and stress scale (DASS-21) one month after discharge from the hospital. Data analysis was performed using descriptive and inferential statistics.

Results

181 males and 129 females with a mean age (SD) of 55.11(1.62) years were enrolled in the study. The prevalence of depression, anxiety and stress were 46.5, 53.6 and 57.8% respectively, and the depression, anxiety and stress mean (SD) scores were 16.15(1.40), 18.57(1.46), 19.69(1.48), respectively. A statistically significant association was reported between depression, anxiety and stress with an increase in age, the number of children, occupation, education, length of hospital stay, use of mechanical ventilation, type of the critical care unit, and drug abuse.

Conclusion

The prevalence of depression, anxiety and stress in patients discharged from critical care units was high. Therefore, crucial decisions should be made to reduce depression, anxiety and stress in patients discharged from critical care units by educational strategies, identifying vulnerable patients and their preparation before invasive diagnostic-treatment procedures.
Keratitis induced by soft contact lens
Authors:   Ufa Eye Research Institute, Ufa, Usubov Е.L. , Rusakova I.A. ,   Ufa Eye Research Institute, Ufa, Rakhimova E.M. ,   Ufa Eye Research Institute, Ufa
Published: May 2021

A clinical case demonstrates that improper use of soft contact lenses can induce serious changes in the cornea, followed by long-term treatment, which in turn may be ineffective due to the developed antibiotic resistance. In similar cases, the use of UV crosslinking provides an additional antimicrobial effect, which ultimately allows the inflammatory process to be resolved. Key words: keratitis, soft contact lens, crosslinking.
Аnatomical and functional features of eyes in children with the second stage of cicatricial retinopathy of prematurity after laser coagulation
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch, Khabarovsk, Pshenichnov M.V. , Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk Branch, Khabarovsk,   Postgraduate institute for public health specialists, Khabarovsk
Published: May 2021

Purpose. To evaluate anatomical and functional features of eyes in children with the 2nd stage of cicatricial retinopathy of prematurity (ROP) in long-term period after underwent laser coagulation (LC) of threshold stages of ROP. Material and methods. 18 children with the 2nd stage of cicatricial ROP, who in 2008–2009 underwent LC of retina of threshold stages of ROP (the main group). Selection criterion is absence of traction changes in macular area. In patients aged 8–9 years we studied visual evoked potentials (VEP), performed optical coherence tomography in macular area, and ocular biometry. The control was healthy children of similar age. Results. In the main group we revealed: statistically significant differences in increase of foveal thickness; tendency to reduction of retinal thickness in all segments of macular area; in 89% of cases pathological changes were observed in VEP, despite visually intact optic disc and macula. Conclusion. The features of eyes in children with 2nd stage of cicatricial ROP who underwent LC of retina of threshold stages of ROP, were: increase retinal thickness in fovea, uniform decrease in retinal thickness in other sectors in macular area, more smaller anterior chamber of the eye and narrow anterior chamber angle, than healthy peers. Key words: cicatricial retinopathy of prematurity, retinal thickness, anterior chamber of the eye, visual evoked potentials.
Features of regenerative processes in microstructures of the foveolar region after surgery of primary complete macular openings by the method of «temporal inverted ILM flap»
Authors:   Department of eye diseases of Samara State Medical University, Stebnev S.D. ,   Ophthalmic clinic «Eye Surgery», Samara, Stebnev V.S. ,   Department of eye diseases of Samara State Medical University,   Ophthalmic clinic «Eye Surgery», Samara, Skladchikova N.I. ,   Ophthalmic clinic «Eye Surgery», Samara, Vashchenko T.Y. ,   Ophthalmic clinic «Eye Surgery», Samara
Published: May 2021

Purpose. To study the features of regenerative processes occurring in the microstructures of the foveolar region after successful surgery of the primary full-thickness macular holes (FTMH) by the method of «temporal inverted ILM flap». Material and methods. Using spectral optical coherence tomography (SOCT), the features of regenerative processes in the microstructures of the foveolar region were studied in 31 patients (32 eyes) with stage II-IV FTMH according to J. Gass (1995), who were successfully operated on for this reason. Results. Regenerative processes of gradual restoration of microstructures of the foveolar region began from the first days after surgery and continued for 1 year. As a result, the U-shaped foveolar contour was restored, the central retinal thickness changed (from 399±61.4 to 195±61 microns, p<0.05); the external limiting membrane (ELM) and the ellipsoid zone (EZ) were completely restored in 27/32 (84.4%) and 23/32 (71.8%) eyes, respectively. Conclusion. Regenerative processes in the microstructures of the foveolar zone are of a step-by-step nature and are traced for one year after the surgery of the primary FTMH by the method of «temporal inverted ILM flap». The essence of the processes: overlapping FTMH with flaps of ILM, filling its lumen with a «glial plug», restoring the ELM, EZ and interdigitative zones. Key words: foveal microstructure, primary full-thickness macular holes, temporal inverted ILM flap, optical coherence tomography.
The state of corneal endothelial cells in the dynamics of surgical treatment of age-related and diabetic cataracts
Authors:   Ufa Eye Research Institute, Ufa, Totskova S.Y. , Babushkin A.E. ,   Ufa Eye Research Institute, Ufa, Garipova Е.M. ,   Ufa Eye Research Institute, Ufa
Published: May 2021

Purpose. To assess the state of the corneal endothelium in patients with diabetic and immature age - related cataracts before and in the long term after phacoemulsification. Material and methods. There were 25 patients (43 eyes) under observation in total. The average age is 66.4±10.1 years. There were 12 men and 13 women among the surveyed. The average time after cataract phacoemulsification was 5.6±1.7 years. There were 2 groups of patients: group I (main) included 10 patients (16 eyes) with diabetic cataract, group 2 (control) consisted of 15 patients (27 eyes) with immature senile cataract (ISC) without diabetes. Before and after phacoemulsification the central corneal thickness (CCT), as well as polymegatism, pleomorphism, and corneal endothelial cell density (ECD) were studied using an EM-2000 endothelial microscope (Nidek, Japan). Results. In the long-term period after cataract phacoemulsification there was decreasing trend in the corneal endothelial cell density (ECD) as in patients operated on for immature senile and especially diabetic cataracts (by 1.5 times). The initial data of ECD in patients with diabetic cataract in comparison with ISC were lower although not significantly. There was also a decreasing trend in the percentage of hexaganality and the number of normal endothelial cells, as well as an increase in the coefficient of their polymegatism after phacoemulsification in patients with DM in comparison with patients without it. Conclusion. The study showed that phacoemulsification of diabetic cataracts is associated with more pronounced damage to the corneal endothelium when compared with the ISC group. During phacoemulsification with IOL implantation, especially in patients with diabetic cataracts, you should pay attention to the initially possible smaller ECD and take this circumstance into account when performing phacoemulsification. Key words: diabetic cataract, surgical treatment, phacoemulsification, endothelial microscopy, corneal endothelial cells.
120th Anniversary of the opening of the Ufa Eye Hospital
Authors:   Ufa Eye Research Institute, Ufa, Galimova Y. S.
Published: May 2021

The article is devoted to the history of the Ufa Eye Hospital of the Ufa department for the blind people, which provided the necessary free ophthalmological and surgical care to patients with eye diseases. The lack of a special institution before the opening of the Hospital led to a large need for ophthalmic care. In view of the lack of proper attention to the problems of the blind and visually impaired on the part of the authorities and the public, there were difficulties in the work of the Hospital, which prevented its consistent development. However, by the mid- 20s of XX century the Ufa Eye Hospital was able to increase the number of people who got ophthalmological care. Key words: Ufa Eye Hospital, Ufa department of the Guardianship for blind people of Empress Maria Aleksandrovna, ophthalmological care, A. A. Belskiy.
Ophthalmopathology of the old people. Population research. Preliminary results
Authors:   Ufa Eye Research Institute, Ufa, Bikbov M.M. , Gilmanshin T.R. ,   Ufa Eye Research Institute, Ufa, Zainullin R.M. ,   Ufa Eye Research Institute, Ufa, Kazakbaeva G.M. ,   Ufa Eye Research Institute, Ufa, Rakhimova E.M. ,   Ufa Eye Research Institute, Ufa, Rusakova I.A. ,   Ufa Eye Research Institute, Ufa
Published: May 2021

Currently, the percentage of old people is growing from year to year in developed countries their share ranges from 10 to 15% of the entire population. In connection with such trends the issue of old age should be given special attention. Purpose. Identify the main risk factors and assess the incidence of ophthalmopathology among the elderly. Material and methods. In Ufa Eye Research Institute was examined 1526 people over 85 years old. Ophthalmological examination included standard and additional diagnostic methods: ultrasound biometry, keratotopography, computed perimetry, ophthalmoscopy using a fundus camera, optical coherence tomography. Results. The main cause of vision loss in the elderly was cataract – 41.7%, followed by AMD – 32.6%, then glaucoma – 10.1%, other eye diseases – 8.1%, optic disc pathology – 54.1% and diabetic angioretinopathy – 2.4%. The most significant association of the ophthalmopathology development is associated with such factors as age, gender, region of residence, axial length of the eye. Conclusions. Timely detection of ophthalmic pathology among old people will allow to preserve the patients visual functions, increase the social rehabilitation level and ensure their active and creative longevity. Key words: old age, cataracts, age-related macular degeneration, glaucoma.