bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of the content and type of binder on the strength of glass fiber paper
Authors: Дубовый В.К. , Криницин Н.А.
Published: November 2020

Проведено исследование композиционного материала на основе минерального волокна с использованием в качестве связующего полиядерных комплексов металлов. Новизной и особенностью данного исследования является использование в качестве связующего для композиционного материала на основе стеклянных волокон полиядерных комплексов титана. Добавление связующего на основе полиядерных комплексов в композицию целесообразно в интервале 5–30% от массы волокна. Исследованный композиционный материал с добавлением в качестве связующего полиядерных комплексов титана имеет прочностные характеристики при рН отлива 10 и 12 выше, чем у материалов с добавлением полиядерных комплексов алюминия и обладает достаточной технологической прочностью. Полиядерные комплексы титана можно использовать как перспективные связующие для композиционных фильтровальных материалов на основе стеклянных волокон.

The study of composite material based on mineral fiber using polynuclear metal complexes as a binder was carried out. The novelty and feature of this study is the use of polynuclear complexes of titanium as a binder for a composite material based on glass fibers. Adding a binder based on polynuclear complexes to the composition is advisable in the range of 5-30% by weight of the fiber. The studied composite material with the addition of polynuclear complexes of titanium as a binder has strength characteristic at pH levels 10 and 12, higher, than that of materials with the addition of polynuclear complexes of aluminum and has sufficient technological strength. Polynuclear complexes of titanium can be used as promising binders for composite filter materials based on glass fibers.
Reflection on the (Un)Power of Men in the Context of Post-war Everyday Life of Croatian War Veterans with Mental Disorders from World War I
Authors: Seferović Jelena
Published: November 2020

U radu se raspravlja o resocijalizaciji hrvatskih branitelja s psihičkim
smetnjama iz Prvog svjetskog rata. Analiza se temelji na istraživanju psihijatrijskih povijesti bolesti vojnika koji su se liječili u dvije hrvatske psihijatrijske bolnice od 1919. do 1924. godine. Proces njihove
socijalne reintegracije u zajednicu nakon povratka s ratišta razmatra se u odnosu na njihovu nemogućnost ispunjavanja normativnih očekivanja vezanih za rodnu uloge muškaraca. Namjera je bila istražiti je li ta okolnost dijelom pridonijela razvoju osjećaja nemoći kod veterana te posljedično uzrokovala njihova asocijalna ponašanja zbog kojih su bili socijalno isključivani iz svoje matične zajednice.
African Generation Y students’ personal finance behavior and knowledge
Authors: van Deventer Marko
Published: November 2020

Personal financial management is important, given uncertainties in both financial and economic environment. However, published research on African Generation Y students’ personal finance behavior and knowledge is limited. This study aimed to evaluate African Generation Y students’ personal finance behavior in terms of their attitudes towards financial planning and whether this cohort believes that they have the skills to manage their finances successfully. In addition, this study sought to evaluate African Generation Y students’ knowledge regarding personal finance. A convenience sample of 500 African students across the campuses of two South African public higher education institutions situated in the Gauteng province was surveyed using structured, self-administered questionnaires. The t-test results indicate that the sample deems the process of planning personal finances and managing credit, insurance, investment, and estate, as important. Moreover, the students scored low in the broad personal finance knowledge areas of basic finance, saving, spending, and debt, suggesting that this cohort is financially illiterate. The results also indicated that the students think they have the financial skillset to manage their personal finances. A high Pearson’s correlation coefficient was noted between sampled participants’ personal finance behavior and their observed personal finance management skillset regarding the relationship between the constructs. However, an insignificant relationship was found between attitudes towards personal finance and financial knowledge and between financial knowledge and African Generation Y students’ apparent finance skills. Understanding African Generation Y students’ personal finance behavior and knowledge, universities and financial institutions can more effectively identify gaps and deficiencies in students’ personal finance endeavors.
Regulatory interventions to sustain circular economy in the water sector. insights from the Italian Regulatory Authority (ARERA)
Authors: Guerrini A. , Manca J.
Published: November 2020

In the circular economy system, the water sector is increasingly becoming a field of concrete experimentation and application on an industrial scale of techniques intended to save and produce energy and to produce materials from water treatment cycles. The water cycle itself represents a ‘circular economy system’ connected to the use of water resources and to the processes of recovery of ‘secondary’ resources, such as energy and raw materials. This paper aims to identify the measures that can be taken by the institutions responsible for regulating the sector to encourage operators to invest in the circular economy and to develop corporate policies based on environmental sustainability and efficiency. It describes: the main actions for the recovery of energy and matter in the management of the water cycle; the current configuration of the regulatory measures adopted in Italy by the Italian Regulatory Authority of Energy, Networks and the Environment (ARERA); and some future developments in regulation policies. The views expressed in this paper are those of the authors and do not necessarily represent those of ARERA.
Therapeutic Management of COVID-19 Patients: Clinical Manifestation and Limitations
Authors: Fatima Urooj , Rizvi Syed Saif A. , Raina Neha , Fatima Saher , Rahman Safikur , Kamal Md. Amjad , Hassan Md. Imtaiyaz
Published: November 2020

Coronavirus disease-2019 (COVID-19) is a respiratory tract infection accompanied by severe or fatal
pneumonia-like symptoms and sometimes death. It has posed to be an ongoing global health emergency caused
by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to a sudden outbreak and a large
number of infections and deaths, it became a major concern all over the world. The options available as effective
therapeutics should be urgently exercised to handle this pandemic. So far, no specific and accurate anti-
SARS-CoV-2 treatment is recommended because of the absence of sufficient clinical evidence. In such cases,
the clinical use of available drugs is always considered to be on top priority. A broad-spectrum antiviral agent,
remdesivir, is found effective in many cases and recommended by many clinicians in many countries. This drug
acts as a potential inhibitor of viral RNA-dependent RNA polymerase protein and thus likely to be efficacious
in SARS-CoV-2 infection. Tocilizumab is currently recommended by many hospitals as an alternative treatment
for critically ill COVID-19 patients. Tocilizumab has been administered to control cytokine storms that
occur due to the release of proinflammatory cytokine, including interleukin 6. Chloroquine and hydroxychloroquine
are also used in hospitals to handle severe COVID-19 patients. Currently, plasma therapy has been exercised
as a therapeutic alternative, especially to handle severe COVID-19 patients. In addition, herbal medicines
are expected to play a significant role in the control and prevention of COVID-19. All these therapeutic options
have their advantages and limitations. This review highlights the therapeutic potential of these available drugs,
along with their mechanism of action and shortcomings. We have provided detailed information on available
therapeutic options, which have proved to be effective in improving clinical symptoms of severe COVID-19
patients.
Identification of Crucial Genes and Diagnostic Value Analysis in Major Depressive Disorder Using Bioinformatics Analysis
Authors: Gao Yao , Zhao Huiliang , Xu Teng , Tian Junsheng , Qin Xuemei
Published: November 2020

Aim and Objective:

Despite the prevalence and burden of major depressive disorder
(MDD), our current understanding of the pathophysiology is still incomplete. Therefore, this paper
aims to explore genes and evaluate their diagnostic ability in the pathogenesis of MDD.

Methods:

Firstly, the expression profiles of mRNA and microRNA were downloaded from the
gene expression database and analyzed by the GEO2R online tool to identify differentially
expressed genes (DEGs) and differentially expressed microRNAs (DEMs). Then, the DAVID tool
was used for functional enrichment analysis. Secondly, the comprehensive protein-protein
interaction (PPI) network was analyzed using Cytoscape, and the network MCODE was applied to
explore hub genes. Thirdly, the receiver operating characteristic (ROC) curve of the core gene was
drawn to evaluate clinical diagnostic ability. Finally, mirecords was used to predict the target genes
of DEMs.

Results:

A total of 154 genes were identified as DEGs, and 14 microRNAs were identified as
DEMs. Pathway enrichment analysis showed that DEGs were mainly involved in hematopoietic
cell lineage, PI3K-Akt signaling pathway, cytokine-cytokine receptor interaction, chemokine
signaling pathway, and JAK-STAT signaling pathway. Three important modules are identified and
selected by the MCODE clustering algorithm. The top 12 hub genes, including CXCL16, CXCL1,
GNB5, GNB4, OPRL1, SSTR2, IL7R, MYB, CSF1R, GSTM1, GSTM2, and GSTP1, were
identified as important genes for subsequent analysis. Among these important hub genes, GSTM2,
GNB4, GSTP1 and CXCL1 have the good diagnostic ability. Finally, by combining these four
genes, the diagnostic ability of MDD can be improved to 0.905, which is of great significance for
the clinical diagnosis of MDD.

Conclusion:

Our results indicate that GSTM2, GNB4, GSTP1 and CXCL1 have potential
diagnostic markers and are of great significance in clinical research and diagnostic application of
MDD. This result needs a large sample study to further confirm the pathogenesis of MDD.
Dual Modulators of p53 and Cyclin D in ER Alpha Signaling by Albumin Nanovectors Bearing Zinc Chaperones for ER-positive Breast Cancer Therapy
Authors: P Shyam Sundar , Naresh Podila , A Justin , Wadhwani Ashish , M Suresh Kumar , Jubie Selvaraj
Published: November 2020

The inherited mutations and underexpression of BRCA1 in sporadic breast cancers resulting
in the loss or functional inactivation of BRCA1 may contribute to a high risk of breast cancer. Recent
researchers have identified small molecules (BRCA1 mimetics) that fit into a BRCA1 binding
pocket within Estrogen Receptor alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity,
and overcome antiestrogen resistance. Studies indicate that most of the BRCA1 breast cancer cases
are associated with p53 mutations. It indicates that there is a potential connection between BRCA1
and p53. Most p53 mutations are missense point mutations that occur in the DNA-binding domain.
Structural studies have demonstrated that mutant p53 core domain misfolding, especially p53-R175H,
is reversible. Mutant p53 reactivation with a new class of zinc metallochaperones (ZMC) restores WT
p53 structure and functions by restoring Zn2+ to Zn2+ deficient mutant p53. Considering the role of
WT BRCA1 and reactivation of p53 in tumor cells, our hypothesis is to target both tumor suppressor
proteins by a novel biomolecule (ZMC). Since both proteins are present in the same cell and are functionally
inactive, this state may be a novel efficacious therapeutic regime for breast cancer therapy. In
addition, we propose to use Albumin Nanovector (ANV) formulation for target drug release.
Potential Roles of MyomiRs in Cardiac Development and Related Diseases
Authors: Abkhooie Leila , Sarabi Mostafa M. , Kahroba Houman , Eyvazi Shirin , Montazersaheb Soheila , Tarhriz Vahideh , Hejazi Mohammad S.
Published: November 2020

Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements
for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and
regulate certain aspects of physiological and pathological processes in myocardiocytes, including
cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through
different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed
the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders.
In this review, we have summarized recent findings in the field of epigenetic modulations of
myomiRs and cardiac regeneration associated with cardiac diseases.
Veno-Arterial Extracorporeal Membrane Oxygenation in the Adult: A Bridge to the State of the Art
Authors: Gennari Marco , L’Acqua Camilla , Rubino Mara , Agrifoglio Marco , Salvi Luca , Ceriani Roberto , Marenzi Giancarlo , Marana Ivana , Polvani Gianluca
Published: November 2020

Despite the technological advancements in the last 40 years, conditions such as refractory
cardiogenic shock and cardiac arrest still present a very high mortality rate in real-world clinical
practice.
In this light, we have reviewed the techniques, indications, contraindications, and results of the socalled
Veno-Arterial Extracorporeal Circulatory Membrane Oxygenation (VA-ECMO) in the adult
population to evaluate the current results of this temporary cardio-pulmonary support as salvage
and/or bridge therapy in the patient suffering from refractory cardiogenic shock or cardio-circulatory
arrest.
The results are encouraging, especially in the setting of refractory cardiogenic shock and in-hospital
cardiac arrest. Among a selected population, the prompt institution of a VA-ECMO may radically
change the prognosis by sustaining vital functions while looking for the leading cause or waiting
for the reversal of the temporary cardio-respiratory negative condition.
The future directions aim to standardized and shared protocols, miniaturization of the machines,
and possibly the institution of specialized “ECMO teams” for in and the out-of-hospital institution
of the tool.
Anti-Tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells
Authors: Chen Chuan , Zhao Ziyue , Dong Qian , Gao XueHui , Xu Huibin , Yang Runlei , Qin JianChun , Luo Duqiang
Published: November 2020

Background:

Xanthones are a class of heterocyclic natural products, which are promising sources of
anti-cancer leads. Phomoxanthone B (PXB) and Phomoxanthone A(PXA)are xanthone dimers. PXA is wellstudied
as an anti-cancer agent, but PXB is not. In our study, PXB was isolated from the endophytic fungus
Phomopsis sp. By254.

Objective:

The purpose of this study was to identify the underlying anti-tumor mechanisms of PXB in breast cancer MCF7 cell line.

Methods:

Apoptosis, cell cycle, proliferation, invasion and migration assays were used to assess the antitumor activity of PXB. RNA sequencing was used to analyze the effect of PXB treatment on gene expression in MCF7 cells.

Results:

PXB showed cytotoxicity towards a variety of tumor cells, especially MCF7 cells. PXB inhibited the
migration and invasion, arrested cell cycle at G2/M phase, and induced apoptosis associated with caspase-3
activation in MCF7 cells. The detailed transcriptome analysis revealed that PXB affected several pathways
related to tumorigenesis, metabolisms, and oxidative phosphorylation in MCF7 cells. KEGG transcriptome
analysis revealed that PXB upregulated pro-survival signal pathways, such as MAPK, PI3K-AKT, and STAT3
pathways. We found that PXB also significantly upregulated the expression of IL24, DDIT3, and XAF1, which
may contribute to PXB-induced apoptosis. We further found that PXB may downregulate oxidative
phosphorylation by decreasing the expression of electron transport chain genes, especially MT-ND1, which is a
potential unfavorable prognostic marker for ER-positive breast cancer.

Conclusion:

PXB exerts strong cytotoxicity against human tumor cells and has a potential for ER-positive breast
cancer treatment.
Adaptive Frame of Universal Vehicle Course
Authors: Asemkhanuly A. , Niyazova Zh. , Karpov A. , Ustemirova R. , Kainarbekov A.
Published: November 2020

Background:

Motor vehicles play an important role in the economies of many countries, providing efficient means of transporting goods and people. These vehicles can also have significant impacts on safety, infrastructure and the environment.

Methods:

The design of the suspension affects the vehicle's performance, in terms of the drive, damage to infrastructure, the working space of the suspension, power, and stability against overturning, stability against yaw, braking, and traction.

Results:

The article considers the types and methods of application of adaptive suspensions of modern vehicles, justifies the feasibility of their use for various vehicles, such as modern cars, tractors, etc., which allows the usage of these vehicles for traffic in different road conditions - mountainous terrains with a slope of more than 35o, steppe off-road conditions with frontal obstacles up to half the length of the wheel radius.

Conclusion:

The existing control schemes and prospects for their further development can be improved and intelligent transport systems could be introduced.
Association Between Awareness of Informal Caregivers and Falls in Elderly Patients with Uncontrolled Diabetes Mellitus
Authors: Chamnankit Tossapon , Ong-artborirak Parichat , Wangrath Jukkrit
Published: November 2020

Background:

Elderly people with uncontrolled diabetes mellitus (DM) are at risk of falls, which can lead to injury and disability. Not much is known of informal caregivers’ awareness of falls in elderly patients with DM.

Objective:

This study aims to identify an association between caregiver’s awareness and falls in elderly patients with DM.

Methods:

A total of 136 pairs of DM patients and their respective family caregivers were recruited from a clinical service center at Chiang Mai University, Thailand. The questionnaire regarding the caregiver’s awareness of the risk of falls in elderly patients was given via a face-to-face interview. Each elderly patient was asked about their history of falls in the prior year, and the risk of falls was assessed by Time Up & Go (TUG) test. Logistic regression analysis was performed to determine association.

Results:

The mean age of the DM patients was 65.7 years. Sixty-two patients (45.6%) had fallen at least once in the prior year. The mean TUG test result was 12.67±1.83 second. Most caregivers demonstrated a high level of awareness regarding the risk of falls in elderly patients. The results of the multivariable analysis showed that three variables – balance problems, risk of falls assessed by TUG test, and scores of caregiver’s awareness of risk of falls – were significantly related to falls in the previous year among elderly patients with DM (p-value<0.05).

Conclusion:

The caregivers’ awareness of fall risk may influence fall occurrence among older adults with DM. An intervention program to improve awareness among informal caregivers should be considered for fall prevention in elderly people.
Isatin: A Scaffold with Immense Biodiversity
Authors: Nath Priyobrata , Mukherjee Agnish , Mukherjee Sougata , Banerjee Sabyasachi , Das Samarpita , Banerjee Subhasis
Published: November 2020

Isatin is an endogenous and a significant category of fused heterocyclic components and
has widely been a part of several potential biologically useful synthetics. Since its discovery, tons of
research work has been conducted with respect to the synthesis, chemical properties, and biological
and industrial applications. It contains an indole nucleus having both lactam and keto moiety, which,
while being a part of a molecular framework, exerted several biological effects, viz.; anti-microbial,
anti-tubercular, anticonvulsant, anti-cancer, etc. Isatin derivatives are synthetically significant substrates,
which can be utilized for the synthesis of huge diversified chemical entities of which few
members emerged as drugs. The reason for this review is to provide extensive information pertaining
to the chemistry and its significance in altering several pathological states of isatin and its derivatives.
A Structure-Activity Relationship study thus developed through a gamut of scientific information indicates
the importance of mostly electron-withdrawing groups, halogens, nitro, alkoxy, and, to a minor
extent, groups with positive inductive effects, such as methyl at position 1, 5, 6 and 7 of isatin in
alleviating several clinical conditions. It is also observed from the survey that the presence of two oxo
groups at positions 2 and 3 sometimes becomes insignificant as a fusion with a heterocycle at these
positions resulted in a biologically relevant compound.
Using Genetic Algorithm for Investigating the Performance of Carbonbasalt/ Polyester Hybrids Composite Materials
Authors: Belkheir Mohammed , Doumi Bendouma , Mokaddem Allel , Boutaous Ahmed
Published: November 2020

Background::

The composite materials are more efficient and more resistant compared
to so-called traditional materials. The application of continuous and variable forces modifies the
properties of the materials, and generates the formation of cracks which lead to the rupture of
structures.

Objective::

The objective of this work is to study the reliability and the origin of the resistance of
each fiber-matrix interface of the two hybrid composite materials studied.

Methods::

In this study, the genetic algorithm is based on Weibull’s probabilistic approach to calculate
the damage to the interface and also on the Cox model to find and initialize the different
values used in simulation model.

Results::

The results obtained by genetic modeling, have shown that the hybrid Carbon High Modulus
(HM)/Basalt/Polyester composite is the most resistant to the mechanical stresses applied
comparing with that of Carbon High Strength (HS)/Basalt/Polyester. These results were confirmed
by the level of damage to the interface found for the two materials studied and that the interface
shear damage of the hybrid Carbon HM/Basalt/Polyester composite is much lower by 13% compared
to that of Carbon HS/Basalt/Polyester.

Conclusion::

The calculations are in good agreement with the analytical results of Cox, where he
demonstrated that Young’s modulus of the fibers has an important influence on the shear strength
of the fiber/matrix interface of composite materials.
How Patient Work Changes Over Time for People With Multimorbid Type 2 Diabetes: Qualitative Study (Preprint)
Authors: Yin Kathleen , Jung Joshua , Coiera Enrico , Ho Kenneth W K , Vagholkar Sanjyot , Blandford Ann , Rapport Frances , Lau Annie Y S
Published: November 2020

BACKGROUND

The experiences of patients change throughout their illness trajectory and differ according to their medical history, but digital support tools are often designed for one specific moment in time and do not change with the patient as their health state changes. This presents a fragmented support pattern where patients have to move from one app to another as they move between health states, and some subpopulations of patients do not have their needs addressed at all.

OBJECTIVE

This study aims to investigate how patient work evolves over time for those living with type 2 diabetes mellitus and chronic multimorbidity, and explore the implications for digital support system design.

METHODS

In total, 26 patients with type 2 diabetes mellitus and chronic multimorbidity were recruited. Each interview was conducted twice, and interviews were transcribed and analyzed according to the Chronic Illness Trajectory Model.

RESULTS

Four unique illness trajectories were identified with different patient work goals and needs: living with stable chronic conditions involves patients seeking to make patient work as routinized and invisible as possible; dealing with cycles of acute or crisis episodes included heavily multimorbid patients who sought support with therapy adherence; responding to unstable changes described patients currently experiencing rapid health changes and increasing patient work intensity; and coming back from crisis focused on patients coping with a loss of normalcy.

CONCLUSIONS

Patient work changes over time based on the experiences of the individual, and its timing and trajectory need to be considered when designing digital support interventions.

INTERNATIONAL REGISTERED REPORT

RR2-10.1136/bmjopen-2018-022163
Higher-Dose Sitagliptin and the Risk of Congestive Heart Failure in Older Adults with CKD
Authors: Muanda Flory T. , Weir Matthew A. , Bathini Lavanya , Clemens Kristin K. , Perkovic Vlado , Sood Manish M. , McArthur Eric , Sontrop Jessica M. , Kim Richard B. , Garg Amit X.
Published: November 2020

Background and objectives

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is commonly prescribed to patients with type 2 diabetes. As this drug is primarily eliminated by the kidney, a reduced dose is recommended for patients with CKD. Some evidence suggests that sitagliptin is associated with a higher risk of congestive heart failure, particularly at higher doses. We compare the 1-year risk of death or hospitalization with congestive heart failure in patients with CKD newly prescribed sitagliptin at >50 versus ≤50 mg/d.

Design, setting, participants, & measurements

This population-based cohort study included older adults (>66 years) with type 2 diabetes and an eGFR<45 ml/min per 1.73 m2 (but not receiving dialysis) who were newly prescribed sitagliptin between 2010 and 2017 in Ontario, Canada. We used inverse probability of treatment weighting on the basis of propensity scores to balance baseline characteristics. The primary composite outcome was death or hospitalization with congestive heart failure. Secondary outcomes included hospitalization with pancreatitis or hypoglycemia, all-cause hospitalization, and glycemic control. Weighted hazard ratios were obtained using Cox proportional hazards regression, and 95% confidence intervals were obtained using bootstrap variance estimators.

Results

Of 9215 patients, 6518 started sitagliptin at >50 mg/d, and 2697 started sitagliptin at ≤50 mg/d. The 1-year risk of death or hospitalization with congestive heart failure did not differ significantly between groups (79 versus 126 events per 1000 person-years; weighted hazard ratio, 0.88; 95% confidence interval, 0.67 to 1.14); hospitalization with pancreatitis (weighted hazard ratio, 0.98; 95% confidence interval, 0.32 to 3.03) and hypoglycemia (weighted hazard ratio, 1.10; 95% confidence interval, 0.64 to 1.90) also did not differ significantly between groups. Patients starting sitagliptin at >50 mg/d had lower mean glycated hemoglobin concentrations (weighted between-group difference, −0.12%; 95% confidence interval, −0.19 to −0.06) and a lower risk of all-cause hospitalization (weighted hazard ratio, 0.81; 95% confidence interval, 0.66 to 0.98).

Conclusions

The risk of death or congestive heart failure was not higher in older adults with CKD starting sitagliptin at >50 versus ≤50 mg/d.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_11_25_CJN08310520_final.mp3
Los contornos del daño moral.
Authors: González Cazorla Fabián
Published: November 2020

It’s comment a sentence of Supreme Court of year 2018, which excludes the inconveniences as repairable moral damage by breach of the obligations of supplier. It is concluded that this type of damage should have a minimal magnitude to be repaired, and that its normative concept and limits are two important elements to accept the request of the plaintiff or to determine their rejection.
Pelatihan Pembuatan Laporan Pertanggungjawaban Keuangan Kepala Sekolah dasar di Kota Administrasi Jakarta Barat
Authors: Khuluqo Ihsana El , Istaryatiningtias
Published: November 2020

Pelatihan pembuatan laporan pertanggungjawaban keuangan kepala sekolah dasar di Kota Administrasi Jakarta Barat dilaksanakan untuk mengurangi atau bahkan menghilangkan kesalahan-kesalahan yang terjadi pada penyusunan laporan pertanggungjawaban keuangan sehingga tidak terlibat konflik dengan Badan Pemeriksa Keuangan (BPK). Pelatihan ini dilakukan dengan tujuan memberikan wawasan tentang penyusunan dan penulisan Laporan Pertanggungjawaban Keuangan yang baik merujuk pada peraturan yang berlaku. Metode yang digunakan yaitu dengan menggunakan metode kualitatif melalui pendekatan persuasif. metode ini digunakan karena dinilai tepat dalam melakukan analisis situasi dan menemukan permasalahan serta solusi dari permasalahan tersebut.  Pelaksanaan Pelatihan pembuatan laporan pertanggungjawaban keuangan kepala sekolah dilaksanakan di Sekolah Dasar Meruya Utara 02 dengan diikuti oleh 12 Sekolah Dasar yang terdiri atas kepala sekolah dan juru bayar sekolah dasar negeri di kota administrasi Jakarta Barat. Hasil pelatihan ini yaitu kepala sekolah dan juru bayar sekolah mengetahui dimana letak kesalahan-kesalahan pada penyusunan laporan pertanggungjawaban keuangan sekolah terkait dengan dana Bantuan Operasional Pendidikan (BOP), dana Biaya Operasional Sekolah (BOS) dan Kartu Jakarta Pintar (KJP) serta memberi pengetahuan terkait panduan penyusunan laporan pertanggungjawaban keuangan sekolah berdasarkan aturan baku pemerintah.
Pembelajaran Geometri Menggunakan Aplikasi Geogebra Versi Android
Authors: Fitriani Fitriani , Suddin Sulasri , Abdullahi Abdullahi
Published: November 2020

Geogebra merupakan salah satu aplikasi yang dapat digunakan untuk mempelajarai topik geometri pada matapelajaran matematika. Aplikasi ini sudah tersedia dalam versi android yang dapat dijalankan melalui smartphone. Penggunaan smartphone khususnya di kalangan pelajar di Indonesia yang begitu besar menjadi landasan tim pengabdi memberikan pelatihan penggunaan Geogebra versi android. Pelatihan dibagi menjadi tiga sesi yaitu sesi pengenalan fitur-fitur Geogebra versi android, sesi pemaparan materi-materi geometri beserta contoh soal yang penyelesaiannya menggunakan Geogebra versi android dan sesi terakhir pemberian soal-soal latihan. Tim pengabdi juga memberikan angket pengetahuan awal mengenai geogebra dan tes kemampuan awal. Di akhir pelatihan diberikan pula tes akhir yang juga berisi pendapat siswa mengenai penggunaan geogebra versi andoid. Ditemukan peningkatan skor siswa antara tes awal dan tes akhir serta waktu pengerjaan yang lebih cepat dikarenakan penggunaan sogtware Geogebra versi android. Respon dan pendapat siswa mengenai penggunaan aplikasi ini juga positif dan sangat antusias.
Peningkatan Pemahaman Kesehatan pada Ibu hamil dalam Upaya Pencegahan COVID-19
Authors: Aritonang Juneris , Nugraeny Lolita , Sumiatik  , Siregar Ronni Naudur
Published: November 2020

Pemerintah Indonesia menetapkan bencana non alam penyebaran COVID-19 sebagai bencana nasional dikarenakan bencana ini berdampak meningkatnya jumlah korban jiwa, ekonomi dan luasnya wilayah yang terkena bencana ini. Ibu hamil tercatat salah satu kelompok rentan resiko terinfeksi COVID-19 dikarenakan pada masa kehamilan terjadinya perubahan fisiologi yang mengakibatkan penurunan kekebalan parsial. Pada studi awal dilakukan sebelum kegiatan ditemukannya masih banyak ibu hamil ketika beraktivitas di luar rumah ttidak sesuai dengan protokol kesehatan seperti tidak memakai masker, masih berbicara  dengan tetangga tanpa menjaga jarak, dan sesekali tanpak masih ikut dalam kerumunan dan tingginya tingkat kecemasan ibu hamil pada era pandemi COVID-19 ini. Kecemasan yang di  tunjukkan oleh ibu hamil yang diwawancarai tersebut tidak sesuai atau berbanding terbalik dengan perilaku ibu hamil dalam kepatuhan melaksanakan protokol kesehatan kesehariannya. Sehingga dibutuhkan suatu cara yakni memberikan pendidikan kesehatan melalui penyuluhan dengan tujuan untuk peningkatan pemahaman upaya pencegahan Covid-19 pada ibu hamil, sehingga mengurangi kecemasan ibu hamil selama pandemi COVID-19. Kegiatan ini dilaksanakan di Balai Pengobatan Swasta Mariana, Deli Serdang Sumatera Utara. Dari kegiatan pengabdian masyarakat ini didapati adanya peningkatan pengetahuan dan pemahaman ibu hamil dalam upaya pencegahan COVID-19, adanya penurunan kecemasan ibu hamil selama kehamilan di era pandemi COVID-19, perlu dilakukan kegiatan serupa secara berkesinambungan hingga terjadi perubahan perilaku yang lebih baik. Perlu adanya pemantauan lebih lanjut atas perubahan perilaku setelah dilakukan penyuluhan ini.
Effects of Combination of SGLT-2 Inhibitor and GLP-1 Receptor Agonist on Renal Outcome in T2D with GFR below 30 and Macroalbuminuria : A Case Series
Authors: Kuhadiya Nitesh , Mahmood Israa
Published: November 2020

We hypothesized that the combination therapy of SGLT-2(Sodium-glucose
co-transporter-2)inhibitor and Glucagon-like peptide-1 receptor
agonist(GLP-1RA) provide renal protection in adults with T2D with
estimated GFR (eGFR) below 30ml/minute/1.73 m2. We hereby describe four
consecutively treated high renal risk patients with T2D with eGFR
between 21 to 30ml/minute/1.73m2.
LL-37 levels in nasal secretions are associated with the severity of acute bronchiolitis
Authors: Papadaki Maria , Marmarinos Antonios , Tsolia Maria , Gourgiotis Dimitrios , Soldatou Alexandra
Published: November 2020

Objective: Τo investigate the association of serum vitamin D and nasal
secretion antimicrobial peptides (AMPs) levels with the severity of
acute bronchiolitis. Study design: We conducted a prospective single
pediatric tertiary care center cohort study of inpatients aged 0-18
months with a first episode of acute bronchiolitis from November 1st
2014 to April 30th 2017. Disease severity was determined by the length
of hospitalization and supplemental hospital data. Qualitative
measurements included serum 25(OH)D and nasal secretion LL-37 and
β-defensin-2 levels. Correlations were examined with the Mann-Whitney
and Kruskal-Wallis criteria for qualitative and the correlation
coefficient Spearman’s rho for quantitative factors. Multiple linear and
logarithmic regression were performed in order to adjust for confounding
factors. Results: The study population consisted of 153 infants and
toddlers with mean age 3.6 months (SD: +2.8). The median level of serum
25(OH)D was 51.4 nmol/L (IQR: 29.7-72.2). No association was found
between serum 25(OH)D and AMPs nasal secretions levels. Serum 25(OH)D
and nasal secretion β-defensin-2 levels were not associated with the
severity of bronchiolitis. In contrast, LL-37 levels were inversely
associated with the length of hospitalization (rho = -0.340, p = 0.001)
and the need for medication use (p = 0.001) and this association
remained significant after adjustment for potential confounders.
Conclusion: A significant association between LL-37 nasal secretions
levels with the severity of acute bronchiolitis was found in
hospitalized infants and toddlers. The role of LL-37 in the pathogenesis
of bronchiolitis merits further investigation.
Defibrillation threshold of internal cardioversion prior to ablation predicts atrial fibrillation recurrence
Authors: sawasaki kohei , Inden Yasuya , hosoya natsuko , muto masahiro , Murohara Toyoaki
Published: November 2020

Background: Many studies have reported the predictors of atrial
fibrillation (AF) recurrence after persistent AF (peAF) ablation.
However, the correlation between the atrial defibrillation threshold
(DFT) for internal cardioversion (IC) and AF recurrence rate is
little-studied. We investigated the relationship between DFT prior to
catheter ablation for peAF and the AF recurrence. Method and Results:
From June 2016 to May 2019, we enrolled 82 consecutive patients (mean
age 65.0 ± 12.4 years), including 45 patients with peAF and 37 with
long-standing peAF, at Hamamatsu medical center. In order to assess the
DFT, we performed IC with gradually increasing energy prior to
radiofrequency application. Forty-nine and 33 patients showed DFT values
less than or equal to 10 J (group A) and greater than 10 J or
unsuccessful defibrillation (group B), respectively. During the mean
follow-up duration of 20.5 ± 13.1 months, patients in group B showed
significantly higher AF recurrence rates than those in group A after the
ablation procedure (P = 0.017). Multivariate analysis revealed that the
DFT was the only predictive factor for AF recurrence (OR=1.07; 95% CI:
1.00-1.13, P = 0.047). Conclusions: The DFT for IC was one of the
strongest prognostic factors in the peAF ablation procedure.
Paclitaxel Coated Balloon Fibroplasty: A more effective treatment of chronic symptomatic lead-related venous obstruction?
Authors: Yacob Omar , Brar Vijaywant , Towheed Arooje , Hadadi Cyrus , O'Donoghue Susan , Worley Seth
Published: November 2020

Subclavian venous obstruction is a common complication after cardiac
device placement. Patients typically remain asymptomatic but at times
may present with acute symptoms due to thrombus formation immediately
after device placement or years later, due to chronic obstruction, with
pain and swelling. Various techniques have been attempted to resolve
symptoms in patients with chronic lead-related subclavian obstruction
but are associated with a high recurrence of restenosis. Drug coated
balloons (DCB) have been used subsequently after pre-dilation with
high-pressure balloons, of the stenosed region, in patients with
arteriovenous fistula obstruction, and have shown promising results. We
discuss the utilization of DCB in our patient with chronic subclavian
obstruction due to a permanent pacemaker lead.
Generalized fractional Hermite-Hadamard type inclusions for co-ordinated convex interval-valued functions
Authors: KARA Hasan , BUDAK Hüseyin , Ali Muhammad Aamir
Published: November 2020

In this paper, we introduce the notion of generalized fractional
integrals for the interval-valued functions of two variables. We
establish Hermite-Hadamard type inequalities and some related
inequalities for co-ordinated convex interval-valued functions by using
the newly defined integrals. It is also proved that the results given in
this paper are the strong generalization of already published ones.
Locally Artinian Supplemented Modules
Authors: TURKMEN BURCU , Şahin Yavuz
Published: November 2020

In this paper, we introduce notions of RLA-local modules and locally
artinian supplemented modules which are proper generalizations as
notions of strongly local modules and ss-supplemented modules,
respectively and we study some properties of these module. In
particular, we give a characterization of semi perfect rings and left
perfect rings.
Ventricular activation pattern assessment during right ventricular pacing; ultra-high-frequency ECG study
Authors: Curila Karol , Jurak Pavel , Halamek Josef , Prinzen Frits , Waldauf Petr , Karch Jakub , Stros Petr , Plesinger Filip , Mizner Jan , Susankova Marketa , Prochazkova Radka , Sussenbek Ondrej , Viscor Ivo , Vondra Vlastimil , Smisek Radovan , Leinveber Pavel , Osmancik Pavel
Published: November 2020

Background: Right ventricular (RV) pacing causes delayed activation of
remote ventricular segments. We used the UHF-ECG to describe ventricular
depolarization when pacing different RV locations. Methods: In 51
consecutive patients, temporary pacing was performed at the RV apex,
anterior and lateral wall, and at the RV septum with (cSp) and without
direct conductive tissue engagement (mSp) (further subclassified as RVIT
and RVOT for septal inflow and outflow positions). The timing of UHF-ECG
electrical activations were quantified as: left ventricular lateral wall
delay (LVLWd; V8 activation delay), RV lateral wall delay (RVLWd; V1
activation delay), and LV lateral wall depolarization duration (V5-8d).
Results: The LVLWd was shortest for cSp (11 ms (95% CI; 5;17), followed
by the RVIT (19 ms (11;26) and the RVOT (33 ms (27;40),
(p<0.01 between all of them), although the QRSd for the latter
two were the same (153 ms (148;158) vs. 153 ms (148; 158); p=0.99). The
RVOT caused longer V5-8d (9 ms (3;14) compared to the RVIT (1 ms (−5;8),
p<0.05. RV apical capture not only had a worse LVLWd (34 ms
(26;43) compared to mSp (27 ms (20;34), p<0.05), but its RVLWd
(17 ms (9;25) was also the longest compared to other RV pacing sites
(mean values for cSp, mSp, anterior and lateral wall captures being
below 6 ms), p<0.001 compared to each of them. Conclusions:
UHF-ECG ventricular dyssynchrony parameters show that cSp offers the
best ventricular synchrony followed by RVIT pacing, which should be
preferred over RVOT and other RV myocardial pacing locations.
Pregnancy in Cystic Fibrosis: Review of the Literature and Expert Recommendations
Authors: Jain Raksha , Kazmerski Traci , Zuckerwise Lisa , West Natalie , Montemayor Kristina , Aitken Moira , Cheng Edith , Roe Andrea , Wilson Alexandra , Mann Caitlin , Ladores Sigrid , Sjoberg Jacqui , Taylor-Cousar Jennifer
Published: November 2020

Cystic fibrosis (CF) was historically a disease largely afflicting
children. Due to therapeutic advancement, there are now more adults with
CF than children. In the past decade, medications became available that
treat the underlying cause of CF and are dramatically improving lung
function as well as quality and quantity of life for people with CF. As
a result, more women with CF are having babies. We gathered a panel of
experts in CF care, family planning, high risk obstetrics, nutrition,
genetics and women with CF to review current literature on pregnancies
and to provide care recommendations for this unique population.
Infrared thermal imaging detection of debonding defects in carbon fiber reinforced polymer based on pulsed thermal wave excitation
Authors: Bu Chi-Wu , Zhao Bo , Liu Tao , Liu Guo-Zeng , Liao Chang-Yu , Tang Qing-Ju
Published: November 2020

The carbon fiber reinforced composite has been widely used in many fields of
the aviation industry due to the good resistance to fatigue damage, impact
resistance, and easy processing. Firstly, the pulse heat conduction model of
the carbon fiber reinforced composite is established, and the simulation
experiment is completed based on the customized specimen with the defects.
The influences of the thermal excitation power and pulse width on the defect
detection effect are analyzed and obtained. The total harmonic distortion
algorithm is used to process the experimental image sequence. The
simulation and experimental results are compared and analyzed to verify
their unity. It may provide the theoretical basis and empirical guidance
for the defect detection of the composite materials.
Cutaneous non-epitheliotropic large T-cell lymphoma in an English Bulldog
Authors: Silva Halana , Horta Rodrigo , Sena Bruna , Pinto Ana Carolina , Almeida Isabella , Rangel Júlia , Souza Tayse , Flecher Mayra
Published: November 2020

Cutaneous lymphoma is histologically classified in epitheliotropic and non-epitheliotropic, the first showing higher incidence in dogs, and the second, in cats. Non-epitheliotropic lymphoma presents lymphocyte aggregates in the dermis and subcutaneous tissue, however cutaneous annexes are not infiltrated. It is usually more aggressive than epitheliotropic lymphomas. The aim of this study was to report a case of non-epitheliotropic lymphoma in a 9-year-old, female, English Bulldog presented with non-ulcerated skin nodules adhered to deep tissues. Microscopic and immunophenotypic features supported the diagnosis of non-epitheliotropic large T-cell lymphoma. Treatment was initiated with modification of the LOPP protocol, replacing procarbazine by dacarbazine (600 mg/m²) for up to six cycles, with a three-month survival. In the 11th week of treatment, after recurrent episodes of vomiting and diarrhea, abdominal ultrasound was performed and revealed an infiltrative mass in the stomach's greater curvature topography, showing an expansive and accentuated increase in one week, when euthanasia was elected.
Post-implementation Evaluation of a Digital Dictation System in a Large Health Service Using HOT-Fit Framework
Authors: Bain Christopher , Goswami Aniruddha , Lloyd Sheree , Davis Laura
Published: November 2020

Objective: The objective of this study was to evaluate a digital dictation system (DDS) that has been implemented in a large health service. The data collected in this study was used to understand the overall uptake and performance of the system and consequently improve the quality of care delivered by the organisation.                          
Methods: A mixed method research design was used in this study. Clinicians and Medical Transcriptionists using the DDS across the two campuses of the health service over a period of four months, were surveyed to assess the extent to which the implementation of the DDS is fulfilling its purpose. In addition, system usage statistics, project implementation documents and user support emails were also analysed.
Results: This study utilised an existing comprehensive and validated evaluation framework, the Human, Organisation and Technology Fit (HOT-Fit) framework. Human fit: 79.55% (n=35) of Clinicians and 33.33% (n=2) of MTs reported an overall satisfaction with the DDS. Organisation fit: The document analysis revealed that the DDS selected aligned best with current organizational IT strategies and was an easy fit with existing practices. Technology fit: An overall satisfaction of 53.49% (n=23) from the Clinicians and 16.67% (n=1) from the MTs was reported on the DDS. Out of 22 issues lodged regarding the system, 77.27% (n=17) issues met the Service Level Agreement (SLA).
Conclusions: The overall findings of the study suggest that, the DDS was a good fit within the organisation in terms of Human fit and Organisation fit. In terms of Technology fit there existed some technical issues on the end-user level due to the system being new to the end users. To overcome this and facilitate the smooth functioning of the DDS, effective communication with the vendor and other relevant stakeholders was recommended so that end users i.e. the Clinicians and MTs understand the system, its functionality and their role in providing timely and high-quality information for clinical care.
Care Burden in Informal Caregivers of Hemodialysis Patients: A systematic review and meta-analysis study
Authors: Jafari-Koulaee Azar , Goudarzian Amir Hossein , Beik Sima , Heidari Tahereh , Hesamzadeh Ali
Published: November 2020

Background: Correct assessment of care burden in informal care providers to hemodialysis patients such as family members has a crucial role in promoting their physical and mental health, so this study was conducted to determine care burden in informal caregivers of hemodialysis patients.
Methods: This systematic review and meta-analysis was performed based on the systematic review meta-analysis and reporting system. To access relevant studies in the field, databases of Medline via PubMed, SCOPUS, ProQuest, SID, Embase and Magiran databases were searched with keywords assigned and using AND & OR operators until 1th August, 2019. After eliminating duplicates and primary and secondary screening of the articles, finally 8 studies entered the meta-analysis process. Cochran test and I2 index were used to determine the heterogeneity of the studies. Random Effects Model was used to estimate pooled mean. Egger's tests were used to evaluate diffusion bias.
Results: The level of care burden in informal caregivers of hemodialysis patients varied from 1.7 to 54.01 in 8 studies with a sample size of 651. The majority of caregivers were spouses of patients and their mean age ranged from 32 to 51 years. Based on the cumulative graph, the mean total effect for care burden index in caregivers of hemodialysis patients in the studies was estimated to be 8.918 (14.3-454.381) with 95% confidence interval based on random effect model.
Conclusion: Considering the care burden in caregivers of hemodialysis patients and its adverse effects, it is recommended to pay more attention to the health of caregivers as hidden patients and appropriate strategies should be considered to improve their quality of life.