bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation of Magnetotargeting of Medicines Based on the Calculation of Permeability of Human Tissues by the Electromagnetic Field
Authors: Churakov A. V. , Kamlach P. V. , Ongarbayeva A. I.
Published: August 2023

Analysis of studies in the field of targeted delivery of drugs, genes and stem cells showed a low level of accuracy of both applied and practical research in this area. Sufficiently encouraging results were obtained with extracorporeal electromagnetic action on a pharmacological complex with a ferromagnetic nanoparticle. With this approach, it is rather difficult to implement the algorithm for introducing the drug into the topographic region (target organ), since in practice, approaches to the clinical application of drug transport technology, taking into account the physicochemical properties of human body tissues, have not been studied in detail. The available models represent various physical and mathematical approaches that do not take into account the bioelectrical and electrostatic properties of the tissues of the organisms of experimental animals and humans. The creation of algorithms and software simulation of this technology will allow calculating variable frequency variables for magnetotargeting in a human digital phantom, which will reduce time spent at the stage of pilot and clinical trials and in the future will form the applied part of the innovative technology. The article presents the methodology and results of multiphysics and mathematical modeling in the Sim4Life for Science, V7.0 package on the example of calculating the control parameters of the electromagnetic field of the region in the area of normal administration of drugs – the vessels of the forearm.
Empleando los sentidos para regular emociones. Revisión bibliográfica sobre “comfort room” en salud mental
Authors: Aragonés Calleja Miriam
Published: August 2023

Resumen
Objetivo: El objetivo principal de esta revisión fue examinar la evidencia científica publicada hasta la fecha sobre la implementación de salas sensoriales/confort en unidades psiquiátricas.
Método: Se realizó una revisión bibliográfica en las bases de datos PubMed, CINAHL, CUIDEN, Scopus y EMBASE empleando la siguiente estrategia de búsqueda: (relaxation room OR sensory room OR comfort room) AND (mental healthORmental illnessORpsychiatr*). Finalmente, se incluyeron un total de 15 artículos.
Resultados: Los principales objetivos de las salas sensoriales son proporcionar un ambiente terapéutico de apoyo, mejorar la calidad de la experiencia dentro del ambiente de la sala y apoyar a las personas a la regulación emocional
durante períodos de angustia y crisis. Algunos de los aspectos positivos del uso de estas salas son el aumento del bienestar general de los usuarios/as y la reducción de las medidas coercitivas ante un episodio de agitación.
Conclusiones: Aunque el uso de las salas sensoriales en psiquiatría es algo novedoso y necesita más investigación sobre su efectividad, la escasa literatura muestra que las “salas de confort” son una herramienta eficaz para fomentar la independencia de la granmayoría de los usuarios/as en su regulación emocional.

Palabras clave: confort, relajación, sala sensorial y salud mental.

Abstract
Objective: The main objective of this review was to examine the scientific evidence published to date on the implementation of sensory/comfort rooms in psychiatric units.
Method: A bibliographic review was carried out in the Pubmed, CINAHL, CUIDEN, Scopus and EMBASE databases using the following search strategy: (relaxation room OR sensory room OR comfort room) AND (mental health OR mental illnessORpsychiatrist *). Finally, a total of 15 articles were included.
Results: The main objectives of the sensory rooms are: to provide a supportive therapeutic environment, to improve the quality of the experience within the environment of the room and to support people in emotional regulation during
periods of distress and crisis. Some of the positive aspects of the use of these rooms are the increase in the general well-being of the users and the reduction of coercive measures in the event of an episode of agitation.
Conclusions: Although the use of sensory rooms in psychiatry is something new and needs more research on its effectiveness, the limited literature shows that “comfort rooms” are an effective tool to promote the independence of the vast majority of users in their emotional regulation.

Keywords: comfort, relaxation, sensory roomand mental health.
Optimizing broadband metamaterial absorber using deep reinforcement learning
Authors: Murakami Kenki , Kubo Wakana
Published: August 2023

Optimization of the geometry of broadband metamaterial absorbers is crucial for improving the performance of optoelectronic devices. However, a large number of geometric parameters should be considered to achieve broad absorption, which is time-consuming. Herein, we propose a rapid and simple method for optimizing metamaterial absorbers dedicated to thermal radiation absorption using deep reinforcement learning. Deep reinforcement learning generated an ideal geometry for a broadband metamaterial absorber after 4 h, demonstrating the effectiveness of this technique for the rapid and effective optimization of metamaterial absorbers.
Numerical calculation method for the mean free path of single-mode semiconductor nanosheets with surface roughness
Authors: Okada Jo , Tanaka Hajime , Mori Nobuya
Published: August 2023

A numerical calculation method is proposed to compute the transport mean free path of single-mode semiconductor nanosheets with surface roughness, where the mean free path is extracted from the statistical average of the logarithm of the dimensionless resistance. The present method requires only a computationally less demanding coherent transmission probability, and is applicable to wider channel length ranges from the quasi-ballistic to the localization regime. The channel thickness, T
w, dependence of the mean free path calculated by the proposed method within the effective mass approximation shows the well-known T
W
6 dependence for thicker T
w, while it becomes weaker for thinner T
w.
The Van der Pol Fourier Integral Representation of the Riemann Zeta Function
Authors: kermiche noureddine
Published: August 2023

The Van der Pol Fourier representation of the Riemann Zeta function in the critical strip is evaluated using the Fast Fourier Transform (FFT) algorithm and the Method of Stationary Phase. The Method of Stationary Phase approximation allows us to introduce a new representation for the zeta function. The new representation is used to propose new analytic predictions about non-trivial zeros.
Ancient Egyptian paleopathology – The population of the tomb of IPI, necropolis of Dahshur-South
Authors: Nerlich Andreas G.
Published: August 2023

This study investigated the human remains of the tomb complex built by the ancient Egyptian high ranking official “Ipi” (4th Dynasty, ca. 2700-2600 BCE) in the Lower Egyptian necropolis of Dahshur-South. Beyond burials from the tomb owner and his family from the Old Kingdom, the complex was re-used until the Late Period. The excavated material presented the human remains of at least 73 individuals. Unfortunately, initial excavations had collected and mixed individual burials, so that individual identification in most skeletons was not possible. Later excavations presented complete individual burials. The custom typical of the New Kingdom until the Late Period of transnasal trephination offered, even with the mixed burials, a collection of 23 disturbed adults’ skulls (New Kingdom until Late Period) and 33 skulls of undisturbed adults (Old Kingdom). In these two groups sex ratios were fairly balanced. Most adult individuals died between 20 to 30 years. There were relatively few immature burials and a single skeleton was that of a 7th lunar month fetus, an obvious stillbirth; total number of immature was 10 (17.8%). Numerous paleopathological observations indicated the considerable impact of living conditions and health. There were 12 cases with healed traumatic sequelae including one with a healed ankylosed fracture of the knee and another with a fracture of the humerus, three cases of nonspecific osteomyelitis, three cases highly suggestive of spinal tuberculosis, one with evidence of metabolic bone disease from vitamin deficiency, and two cases with malignant bone tumours; one with multiple metastases of the vertebrae, and the other chondrosarcoma of the pelvis. Also, typical pathological changes were seen in teeth and jaws. Finally, the rate of osteoarthrosis of large joints and that of spondylosis suggest significant work load. These findings indicate various ailments either due to heavy work load (arthrosis and spondylosis, traumatic sequelae), or to the living conditions (tooth abrasion by sand ingestion; tuberculosis due to foundation of settlements and townships), metabolic osteopathies possibly due to parasitic diseases and/ or malnutrition. These skeletal remains therefore contribute to our understanding of ancient Egyptian life and diseases.
PRODUCTION OF OXIDE DISPERSION STRENGTHENED INCONEL 718 ALLOYS USING CONVENTIONAL POWDER METALLURGY AND ADDITIVE MANUFACTURING METHODS
Authors: AYDOĞAN GÜNGÖR Eda
Published: August 2023

Oxide dispersion strengthened (ODS) Ni-based alloys having a high density of nano-oxides (NOs) (<10 nm) are considered to be good candidates for extreme environments, such as high temperature, radiation, and corrosion. In this study, ODS IN718 alloys have been produced using conventional powder metallurgy (PM) and novel selective laser melting (SLM) additive manufacturing. The effect of processing routes on the microstructure, in particular on the nano-oxide formation and structure has been investigated. It has been found that the powder metallurgy method that consists of compressing followed by sintering at 1250 and 1500 °C results in a nano-granular structure with homogenously distributed fine nano-oxides having a high number density. Similarly, SLM results in a high number density of fine nano-oxides; however, the particles exist in groups with the grains/cells. The nano-oxides are determined to be Y2Ti2O7, Y2TiO5 or YTiO3 and Y-Al-O. The deviation in the lattice parameters of Y2Ti2O7 infers the existence of some Al in the structure. This study sheds light on producing ODS IN718 alloys with high-density nano-oxides using powder metallurgy and additive manufacturing methods.
COMPARISON OF INNOVATIVE TREND ANALYSIS METHODS FOR HYDROMETEOROLOGICAL PARAMETERS IN THE KARASU SUB-BASIN
Authors: KÖYCEĞİZ Cihangir , BÜYÜKYILDIZ Meral
Published: August 2023

Türkiye, which has a complex climate structure, is shown among the countries that will be most affected by climate change with the effect of global warming. These effects will differ in different regions due to their topographic structure, location, and orographic characteristics. Trend analyzes are used to determine the direction and magnitude of this variability. In this study, trend analysis was carried out by using hydrometeorological data obtained from streamflow and meteorology stations located in the Karasu Sub-Basin located in the Euphrates-Tigris Basin. Three innovative trend methods, namely the Şen-Innovative Trend Analysis, Onyutha Trend Test, Combination of Wilcoxon Test and Scatter Diagram trend tests, were used together with the classical Mann-Kendall method in the monthly scale analysis of hydrometeorological data of the 1979-2020 period. Both graphical and statistical trend analysis can be done with innovative methods. The results obtained in the study, in which trend analyses were evaluated at the α=0.05 significance level, reveal significant and insignificant decreasing trends in the parameters of mean streamflow, maximum precipitation, total precipitation, mean and minimum relative humidity. Significant and insignificant increasing trends were determined in the maximum, minimum, and mean temperature, maximum relative humidity, and mean wind speed data. The trends obtained in the methods used in general are consistent with each other. The findings of this study could lead to a better knowledge of the region's hydrology and contribute sustainable water management. The trend analysis methods used in the study are thought to be quite helpful in the analysis of hydro-meteorological time series.
PHENYLETHYLAMINE DERIVATIVE OF CALIX[4]ARENE SCHIFF BASE FOR FLUOROMETRIC DETECTION OF ZINC ION
Authors: ÖZÇELİK Egemen , NG'ANDU Clever , TABAKCI Begüm , TABAKCI Mustafa
Published: August 2023

As a Zn2+ fluorescent probe, we have designed and synthesized a new type of calixarene Schiff-base ligand (L) possessing a 1-phenylethylamine group as the fluorophore and the receptor. As only Zn2+ caused a significant increase in fluorescence emission intensity at 480 nm and the limit of detection (LOD) reached 4.8 x 10-7 M, the synthesized fluorescent probe L demonstrated high selectivity and sensitivity towards Zn2+ compared to other metal ions. In addition, the formation of a 1:1 complex between probe L and Zn2+ was determined. As a consequence, it was determined that probe L can be utilized for the detection and monitoring of Zn2+ in the environment.
Alpha- Thalassemia: An Overview
Authors: Alhuthali Hayaa M.
Published: August 2023

Alpha-Thalassemia is the commonest hereditary monogenic disease worldwide. α-thalassemia is caused by α-globin gene losses and categorized into α-thalassemia 1 and α-thalassemia 2 depending on how many α-globin genes are functioning. Α thalassemia 1 is defined by inactivation of both α-globin genes on a chromosome, while in α-thalassemia 2, one gene is active. The clinical phenotype depends on the degree of genes impairment. This review will present an overview of α-thalassemia, its incidence, causes, and clinical characterization, and discuss different laboratory techniques used for the diagnosis.
Trends in Overtourism Research from 2018 to 2021: Text Mining and Semantic Network Analysis
Authors: Tang Ruohan , Lee Won Seok , Moon Joonho , Shim Ji Min
Published: August 2023

This research aimed to examine overtourism-related papers published in the Web of Science and to identify research structure framework through network analysis between key keywords. Accordingly, the abstract of 110 papers related to overtourism from 2018 to 2021 was reviewed through
text mining using Python. Afterwards, clusters derived through semantic network analysis were found to be Positive/Negative Impact of Tourism Development, Economic Causes, Efforts for Sustainability,” and Necessity of Policy. Through this, it was intended to
present countermeasures against overtourism and directions for establishing policies. In addition, by deriving the main keywords for each cluster, basic data that can examine the relationship between overtourism phenomena in more detail were provided and contributed to the literature.
Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategies
Authors: Lonardo Amedeo
Published: August 2023

Nonalcoholic fatty liver disease (NAFLD) is an umbrella definition that describes the ectopic deposition of fat within the liver that occurs in the absence of inciting factors other than the metabolic syndrome and its individual features. NAFLD has a multi-factorial pathogenesis which determines heterogeneous clinical phenotypes and variable natural course spanning from liver-related (steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinoma) to extrahepatic outcomes (cardio-metabolic and cancer). This narrative review article leverages the key aspects of disease natural history as the background information to discuss studies that may inform strategies to risk-stratify NAFLD patients. Evaluation of hepatic fibrosis with non-invasive tools, including blood-based biomarkers and imaging-based elastometry techniques, seemingly retains the core information useful to predict the heterogeneous outcomes listed above. Additionally, genetic testing and metabolomic profiles may also be utilized to this end. In conclusion, a comprehensive understanding of the variable hepatic, cardio-metabolic and cancer outcomes of NAFLD may enable physicians and researchers to risk-stratify and accurately identify the multilayered prognosis of NAFLD individuals while also defining homogeneous patient subsets to enroll in clinical trials.
Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant
Authors: Ieko Masahiro , Ohmura Kazumasa , Naito Sumiyoshi , Yoshida Mika , Sasaki Hisaomi , Sato Tsuyoshi , Sugawara Norifumi , Takahashi Nobuhiko , Ichinose Akitada
Published: August 2023

In patients with autoimmune coagulation factor deficiency (AiCFD), the production of autoantibodies that inhibit coagulation factors in the blood reduces the activity of those relevant coagulation factors, resulting in severe bleeding symptoms. Recently, reports of patients with AiCFD have noted the concomitant detection of lupus anticoagulant (LA), a risk factor for thrombosis. LA-positive patients may show bleeding symptoms due to decreased activity of coagulation factor II (FII) caused by autoantibodies against FII, in addition to thrombotic symptoms, a condition termed LA-hypoprothrombinemia syndrome (LAHPS). Anti-FII antibodies in LAHPS cases are frequently cleared antibodies that can be detected using immunological techniques, such as enzyme-linked immunosorbent assay (ELISA). Recently, several cases of coagulation FV inhibitors, known as autoimmune FV deficiency, have been reported. Some of these cases may be complicated by LA, which can cause thrombosis. False-positive results for anticoagulant inhibitors are known to occur in LA cases; therefore, immunological confirmation of antibodies against coagulation factors is recommended. Additionally, acquired hemophilia A (AHA), caused by autoantibodies against FVIII, is a typical acquired hemorrhagic diathesis, although affected patients may present with thrombosis associated with LA. Thus, it is important to remember that hemorrhagic diathesis due to autoantibodies against clotting factors can also result in thrombosis, as demonstrated by the co-detection of LA. When clotting factor inhibitors are detected in LA-positive individuals, it is important to confirm the presence of autoantibodies against coagulation factors using immunological methods, such as ELISA, to avoid false-positive results.
Modify gut microbiome in autism: a promising strategy?
Authors: Demarquoy Jean , Othman Haifa , Demarquoy Caroline
Published: August 2023

The gut microbiota and dysbiosis have been implicated in various metabolic diseases and gastrointestinal disorders. Recently, there has been growing evidence suggesting the influence of gut microbiota on neurological disorders, including autism. Although the number of children diagnosed with autism is increasing, the exact cause of the disease remains unknown. Numerous factors, such as genetics, environment, and diet, appear to contribute to its onset. Nevertheless, a degree of general consensus exists regarding the notion that the disease’s progression likely demands the participation of multiple factors. Among the potential causes, the role of the microbiota is particularly intriguing. The gut and brain have extensive connections, with a significant number of neuronal cells in the gut, and autism is often associated with gastrointestinal issues. In this review, the most recent information available on autism and microbiota has been analyzed. Findings of this study indicate that: (1) the microbiota is clearly altered in individuals with autism spectrum disorder (ASD); (2) microbiota transplantation appears to be effective in reducing the severity of autism symptoms; (3) while the microbiota is not solely responsible for the onset of autism, it likely plays a significant role. Considering all the available information, it is suggested that modifying the gut microbiota may have a positive impact on individuals with autism. This opens up possibilities for the use of pre- or probiotics in the treatment of children with ASD, as well as the potential use of fecal microbiota transfer.
Lección 23. Actividad de prestación y garantía
Authors: Magaldi Nuria
Published: August 2023

SUMARIO: 1. INTRODUCCIÓN Y CONCEPTO.—2. DEL SERVICIO PÚBLICO A LA ACTIVIDAD DE PRESTACIÓN Y GARANTÍA: 2.1. La aparición del concepto sociológico y jurídico de servicio público; 2.2. El Estado Social de Derecho como Estado prestador de servicios públicos; 2.3. El Derecho de la Unión Europea y los servicios de interés general: 2.3.1. ¿A qué servicios se aplica el artículo 106 TFUE?; 2.3.2. En los servicios económicos de interés general, ¿es posible garantizar una prestación básica a todo el mundo a un precio asequible?—3. RÉGIMEN JURÍDICO DE LOS SERVICIOS PÚBLICOS: 3.1. La creación de los servicios públicos; 3.2. Las formas de gestión de servicios públicos.—4. LOS PRINCIPIOS RECTORES DE LA ACTIVIDAD DE PRESTACIÓN Y GARANTÍA.—5. BIBLIOGRAFÍA: 5.1. Bibliografía citada; 5.2. Bibliografía complementaria recomendada.
A Mathematical Study on a Steady MHD Flow in Double Stratification Medium
Authors: V. Ananthaswamy  , R. R. Subanya  , S. Sivasankari
Published: August 2023

The detailed analysis on the flow of MHD fluid in double stratification medium across a stretching sheet with exponential permeability is examined in this research. The approximate analytical solution for the governing equations in steady state is found by using a new approximate analytical method called Ananthaswamy-Sivasankari Method (ASM) and Modified Homotopy Analysis Method (MHAM). The approximate analytical expressions for the dimensionless velocity, dimensionless temperature and dimensionless concentration are derived using these methods. The analytical and numerical results (previous work) are compared and there is a good agreement between our analytical results and numerical works. The impacts of several parameters including porosity, magnetic, suction and heat source parameters are shown in graphical representation. The error table for the physical parameter namely Nusselt number for various values of Prandtl number has been provided. Both ASM and MHAM are very useful to solve some other non-linear boundary value problems especially in MHD fluid flow
วงจรเชื่อมต่อสัญญาณสำหรับการตรวจวัดค่าความจุไฟฟ้า
Authors: กองภาค พัชรี
Published: August 2023

บทความนี้นำเสนอวงจรเชื่อมต่อสัญญาณหรือวงจรอินเทอร์เฟซสำหรับการตรวจวัดค่าความจุไฟฟ้าในเซนเซอร์ชนิดเก็บประจุแบบดิฟเฟอเรนเชียล โดยประยุกต์ใช้หลักการของวงจรแปลงค่าความจุไฟฟ้าเป็นสัญญาณดิจิตอล ชนิดซิกม่าเดลต้า ซึ่งวงจรอินเทอร์เฟซนี้จะทำงานบนหลักการเปลี่ยนค่าความจุไฟฟ้าที่เปลี่ยนแปลงในเซนเซอร์ชนิดเก็บประจุไปเป็นค่าดิจิตอลระดับลอจิกสูง “1” และต่ำ “0” โดยวงจรที่นำเสนอประกอบด้วยวงจรแปลงค่าความจุไฟฟ้าเป็นแรงดันไฟฟ้า วงจรอินทิเกรเตอร์ วงจรเปรียบเทียบสัญญาณ วงจรฟลิปฟลอป และวงจรแปลงสัญญาณดิจิตอลเป็นแอนะล็อกโดยป้อนกลับแบบกระแสไฟฟ้า ผลการจำลองการทำงานวงจรพบว่า วงจรสามารถทำงานได้ตามหลักการที่ออกแบบไว้ โดยมีค่าความผิดพลาดสูงสุดโดยประมาณเท่ากับ 0.6% ที่ค่าความจุไฟฟ้าปกติของเซนเซอร์ (C0) 100 pF ค่าเต็มสเกล เท่ากับ 10 % ความถี่อินพุต (Fin) 100 Hz ความถี่ของสัญญาณนาฬิกา (Fclk) 10 kHz
Evaluation of Nursing Educators’ Perceptions of Distance Education During the COVID-19 Pandemic and Affecting Factors
Authors: KARAÇAY Pelin , BAYSAL Ebru
Published: August 2023

Objective: To evaluate perceptions of distance education in nursing educators and affecting factors during COVID-19.

Methods: This descriptive cross-sectional research was conducted with 374 educators from different schools of nursing in Turkey. The data were collected using a Personal Information Form and the Perception of Distance Education Questionnaire and were analyzed by descriptive analysis, independent samples t-test and ANOVA, linear regression analysis, and thematic analysis.

Results: Four factors related to educators’ perceptions of distance education were found: a high level of satisfaction with distance education (DE), incorporating brainstorming and video-viewing techniques, and the realization that course learning outcomes could be achieved. Seven themes regarding advantages of DE emerged: provided better time management, flexibility, and ease of access, video recordings of lessons made learning easier, physical environment issues were solved, DE is a suitable method for theoretical courses, DE made assessment and evaluation easier, DE ensured the continuation of education, and DE improved the educators’ technology skills. In addition, six themes regarding disadvantages of DE emerged: inadequate technological infrastructure, DE caused health problems, deterioration of the learning and teaching process, challenges in applied education, difficulties in assessment and evaluation, and an increase in educator and student workloads.

Conclusion: To increase positive perceptions of nursing educators towards DE, active teaching techniques should be encouraged to increase satisfaction with DE. The perceptions of nursing educators should be taken into consideration to better structure the course curricula and to eliminate the distance education infrastructure deficiencies of the institutions.
TO THE QUESTION OF EFFICACY AND SAFETY OF FORTELYZIN® THERAPY ON ACUTE CORONARY SYNDROME: TWO CLINICAL CASES
Authors: Yunevich D. S. , Aksentiev S. B.
Published: August 2023

The article presents two clinical cases of successful reuse thrombolytic drug Fortelyzin® in the total dose of 25-30 mg observed by the authors in patients with acute coronary syndrome with ST-segment elevation, treated in the urgent cardiology department of the State budget institution of Ryazan region «Regional clinical hospital». Patients belonged to different gender and age groups and had various short term forecast on the scale TIMI or GRACE, different duration of ischemic damage of the myocardium until reperfusion. The above observations confirm the high safety and efficiency of Fortelyzin® in acute coronary syndrome.
Recipes for Jet Feedback and Spin Evolution of Black Holes with Strongly Magnetized Super-Eddington Accretion Disks
Authors: Ricarte Angelo , Narayan Ramesh , Curd Brandon
Published: August 2023

A spinning black hole (BH) accreting from a disk of strongly magnetized plasma via a magnetically arrested disk is known to produce an efficient electromagnetic jet powered by the BH’s spin energy. We present general relativistic radiative magnetohydrodynamic simulations of magnetically arrested systems covering a range of sub- to super-Eddington accretion rates. Using the numerical results from these simulations, we develop formulae to describe the magnetization, jet efficiency, and spin evolution of an accreting BH as a function of its spin and accretion rate. A BH with near-Eddington accretion experiences a mild degree of spin-down because of angular momentum loss through the jet, leading to an equilibrium spin of 0.8 rather than 1.0 at the Eddington limit. As the accretion rate increases above Eddington, the spin-down effect becomes progressively stronger, ultimately converging on previous predictions based on nonradiative simulations. In particular, spin evolution drives highly super-Eddington systems toward a BH spin near zero. The formulae developed in this letter may be applied to galaxy- and cosmological-scale simulations that include BHs. If magnetically arrested disk accretion is common among supermassive BHs, the present results have broad implications for active galactic nucleus feedback and cosmological spin evolution.
Topical Formulation Based on Arnebia euchroma as a Novel Possible Efficient Treatment on Epidermolysis Bullosa Lesions: A Case Series of Fourteen Patients
Authors: Abdollahi Amirsaleh , Kadkhodaee Rouzbeh , Kazeminejad Armaghan , Davoodi Lotfollah , Karimi Muhammadreza Oraee , Razavi Alireza , Najmabad Sobhan Mohebbi
Published: August 2023

BACKGROUND: Epidermolysis bullosa (EB) is a skin fragility disorder that results in the disruption of the dermo-epidermal junction and painful blisters on the skin and mucous membranes. Currently, there is almost no definite treatment for EB patients.
AIM: This study aims to assess the effect of topical formulation based on Arnebia euchroma (AE) on lesions induced by EB.
MATERIALS AND METHODS: All patients with EB diseases treated with Hochobeh ointment (AE+Beewax+Olive oil) in 2022 at our dermatological clinic were included in the study. EB diseases were diagnosed based on the following criteria: (1) clinical features (2) histopathological findings (3) Linear depositions of IgG, IgA, IgM 4. salt-split skin (SSS) or other immune serological tests compatible with the diagnosis of EB disease. Hochobeh ointment and lotion treatment were initiated. Clinical evaluations were repeated 3 and 7 days after the treatment began, and photographs were taken to document the changes in clinical severity. EB Disease Activity and Scarring Index (EBDASI) and EB Quality of Life (EB-QoL) questionnaires were used to assess the severity of EB and the quality of life, respectively. All statistical analyses were performed using statistical package for the social sciences version 16.
RESULTS: Overall, fourteen patients were included. Improvement in clinical features, including reduction of infection and inflammation and improvement of wound healing, was observed. EBDASI and EB-QoL scores decreased significantly after treatment (91.5 ± 45.7 vs. 68.9 ± 43, p = 0.001; 24.6 ± 6.7 vs. 18 ± 5.2, p = 0.001, respectively).
CONCLUSION: Hochobeh ointment may be effective in treating EB skin and mucosal lesions.
Acquired Postpartum Hemophilia A Presentation of Severe Hematuria: A Case Report
Authors: Abdelghany Wafaa M.
Published: August 2023

BACKGROUND: Acquired hemophilia A (AHA) is a rare, severe bleeding disorder caused by the development of autoantibodies against FVIII that may be idiopathic or secondary to medical conditions. Postpartum AHA can occur as early as 1–4 months after delivery or as late as 1-year postpartum.
CASE REPORT: A 20-year-old female presented with vaginal bleeding 20 days after delivery, then ecchymotic patches developed 2 months later, followed by hematuria 2 months after that. Laboratory investigation revealed isolated, prolonged partial thromboplastin time that was not corrected by mixing 50:50 with fresh normal plasma. FVIII activity was markedly deficient, with a high titer of immediate-acting FVIII inhibitor antibodies.
CONCLUSION: The case was diagnosed as postpartum AHA with a good response to the combined steroids and cyclophosphamide treatment.
Evaluation of Plasma Levels of Interferon-Gamma, Interleukin-6, and Transforming Growth Factor-Beta in Under-Five Children with Malaria Parasitaemia
Authors: Ezeokoli Emmanuel Ozioma , Amilo Grace Ifechukwudelu , Izuchukwu E. Chukwuemeka O , Afonne O. Johnson , Ezeanosike Obumneme , Mbamalu Chinenye J , Onwe Sunday O , Ezeokoli Ogochukwu Mary , Ugwu Gabriel Chima
Published: August 2023

BACKGROUND: The interaction between the pro- and anti-inflammatory cytokines is known to play key roles in the immune response to infectious diseases. The pathogenesis of malaria parasitemia, including its progression to symptomatic manifestation, also seems to be strongly related to this interplay.
AIM: The study evaluated the plasma levels of interferon-gamma (IFN-γ) and interleukin-6 (IL)-6, which are pro- inflammatory cytokines, and  transforming growth factor-beta (TGF-β), which is an anti-inflammatory cytokine; in the 6–60 months age-group children, when infected with Plasmodium falciparum, to show their relevance in the development of immunity against malaria.
METHODS: The study was a cross-sectional study involving children with uncomplicated malaria parasitemia. In the study, malaria parasitemia was confirmed by microscopy, using the Giemsa stain. The enzyme-linked immunosorbent assay (ELISA) method was used to evaluate the plasma levels of IFN-γ, IL-6, and TGF-β in the under-five children infected with P. falciparum, and their counterparts who were not infected with the parasite.
RESULTS: The median plasma IFN-γ, IL-6, and TGF-β levels in participants with malaria parasitemia were 225.15 pg/ mL, 123.31 pg/mL, and 2091.02 pg/mL, respectively. The difference in the plasma levels of TGF-β in the infected and uninfected participants was statistically significant with a p < 0.001.
CONCLUSION: The findings in this work showed that malaria parasitemia in under-five children is associated with significant depression in the plasma level of TGF-β when compared to their uninfected counterparts.
Potential anti-inflammatory activity of the Tamarix aphylla essential oil
Authors: Qnais Esam , Alqudah Abdelrahim , Wedyan Mohammed , Athamneh Rabaa Y. , Bseiso Yousra , Abudalo Rawan , Oqal Muna , Gammoh Omar
Published: August 2023

Aim: This study aimed to assess the anti-inflammatory activity and potential mechanisms of essential oil of Tamarix aphylla (EOTA).

Methods: The essential oils were extracted from the plant’s aerial parts using hydrodistillation and analyzed through gas chromatography and mass spectrometry (GC/MS). The essential oils were assessed for their anti-inflammatory effects using well-established inflammation models, namely carrageenan-induced paw edema and peritonitis. To evaluate the antioxidant activity of the essential oil, measurements were taken for nitric oxide radical-scavenging activity and lipid peroxidation.

Results: The predominant components of the EOTA were 6,10,14-Trimethyl-2-pentadecanone (20.2%), β-Ionone (20.1%), Dodecanoic acid (12.2%), and trans-β-Caryophyllene (10%.1). The study found that EOTA significantly reduced edema, peritonitis, myeloperoxidase activity, and NOx-peritoneal lavage concentration induced by carrageenan. Additionally, the essential oil exhibited significant inhibition of nitric oxide radical production triggered by sodium nitroprusside. Furthermore, EOTA demonstrated the ability to prevent lipid peroxidation induced by Fe+2- or Fe+2 plus H2O2.

Conclusion: The findings suggest that EOTA possesses anti-inflammatory activity, potentially linked to its antioxidant capacity.
Description of three new species of Benedictus (Coleoptera, Chrysomelidae, Galerucinae, Alticini) from China, with comments on their biology and modified ethanol traps for collecting flea beetles
Authors: Ruan Yongying , Konstantinov Alexander S. , Damaška Albert F. , Zheng Lihao , Chen Jun , Meng Ziye
Published: August 2023

The diversity and biology of the moss and leaf litter-inhabiting flea beetles are still poorly known. In this study, three new species of Benedictus are described from China: Benedictus fuanensis Ruan & Konstantinov, sp. nov., Benedictus quadrimaculatus Ruan & Konstantinov, sp. nov., and Benedictus wangi Ruan & Konstantinov, sp. nov. Comments on their biology are given. Benedictus quadrimaculatus has a highly unusual morphological feature not reported before in flea beetles: black spots on the abdominal tergites that are visible through the elytra. Traditional and modified ethanol traps were tested and proven useful for collecting leaf litter- and moss-inhabiting flea beetles. Based on our tests, eight traps could collect one specimen each day in the testing sites in Fujian Province; three traps could collect one specimen each day in the testing sites in Guangdong Province.
Hume et la question de la nature de la croyance
Authors: Glauser Richard
Published: August 2023

(1) Alors que Hume distingue plusieurs sortes de propositions, nous expliquons pourquoi il se focalise sur l’inférence causale lorsqu’il examine la nature de la croyance. (2) Après avoir considéré les réponses qu’il écarte concernant la nature de la croyance, nous étudions sa solution. (3) Nous dégageons les implications de sa position, dirigée entre autres contre la théorie cartésienne du jugement. (4) Une interprétation du rôle asymétrique de la croyance par rapport aux passions et à l’action est proposée. (5) La position de Hume au sujet de la nature de la croyance, pensons-nous, rencontre une difficulté : elle est peu apte à rendre compte de la nature de la croyance existentielle négative.
Peut-on seulement savoir ce qu’ est le corps ?
Authors: Caillé Arthur
Published: August 2023

Malgré l’intérêt de Leibniz pour la physique de Huygens, leur correspondance entre 1692 et 1695 renferme plusieurs divergences révélatrices de deux ontologies différentes des corps. Selon Leibniz, les lois de Kepler peuvent être expliquées par une circulation harmonique, alors que Huygens substitue à celle-ci une pesanteur intrinsèque des corps. De plus, pour Huygens, il y a une extension dépourvue de tout corps et pourtant matérielle, ce qui n’est pas compatible avec la métaphysique de Leibniz. Enfin, Huygens explique la cohésion des corps par des atomes extrêmement durs ; Leibniz rejette de telles entités, mais complète les lois du mouvement relatif par un niveau substantiel au-delà de l’étendue.
Apprendre à faire et à penser en organizer
Authors: Petitjean Clément
Published: August 2023

Le développement à partir des années 1970 de curricula de formation constitue l’un des aspects les plus centraux dans l’institutionnalisation des pratiques de community organizing aux États-Unis. Objectivant les revendications d’expertise du groupe professionnel en devenir des community organizers , les programmes de formation apparaissent comme des lieux traversés par des définitions concurrentes du métier, structurées par l’opposition entre un pôle « institutionnel » et un pôle « contestataire » – le premier valorise l’extériorité experte du professionnel tandis que le second met en avant la proximité avec les groupes mobilisés. Pour saisir ces luttes symboliques au ras des pratiques, l’article s’appuie sur l’observation participante d’un stage de formation organisé en mars 2016 par la Midwest Academy, organisme créé en 1973 et qui constitue un lieu de formation incontournable à l’échelle nationale. Il montre pourquoi et comment, dans un contexte de dynamique contestataire entretenue par le mouvement Black Lives Matter, ce stage devient le lieu d’une remise en cause frontale du contenu de formation, donnant à voir des conceptions opposées du rôle d’ organizer .
Préfigurer les interactions entre le design des politiques publiques et les citoyens : le cas d’un site gouvernemental français
Authors: Forthoffer Camille , Pottier Lisa
Published: August 2023

Cet article propose d’analyser le contenu d’un site internet de la DITP ayant pour vocation de faire découvrir le design aux agents de la fonction publique. Ce dernier est analysé en regard de la notion de déprise d’œuvre et de la sémiotique des interactions au sein d’un design des politiques publiques. Considéré au sein d’une organisation publique, nous questionnons le rôle des usagers-citoyens en tant qu’enjeu spécifique du tournant utilisateur en design. Cette analyse est double et rend compte de l’arborescence du site internet et d’une analyse statistique de ses textes. L’article fait donc état des interactions préfigurées entre les agents de la fonction publique, le design et les usagers-citoyens.
Co-design de dispositifs de prévention collaboratifs au service de la prévention des rixes et de la police de sécurité
Authors: Zacklad Manuel , Joubert Didier , Gérard Aline
Published: August 2023

Cet article propose un état intermédiaire d’une recherche en cours portée par le laboratoire Dicen-IdF (équipe du CNAM) et l’UTT. Elle s’inscrit dans le cadre d’un partenariat informel avec la ville des Lilas et la préfecture de Police, commissariat de circonscription des Lilas, qui ont accepté d’ouvrir le terrain à l’équipe de recherche et ses designers. Les chercheurs ont sollicité la collaboration de l’agence de design Vraiment Vraiment, qui se définit comme une agence de design d’intérêt général spécialisée dans l’innovation publique. La recherche met en évidence l’intérêt des méthodes de communication dites dialogiques ou collaboratives pour contribuer aux actions de prévention à destination des regroupements de jeunes et, dans notre cas, à prévenir des rixes. Elle contribue également l’expérimentation de méthodes de Recherche Intervention par le Co-Design (RICO-D) à travers laquelle les chercheurs s’associent à des designers pour co-produire avec les acteurs de terrain l’analyse des situations et les propositions de solutions. Après une présentation du contexte et du terrain nous passerons en revue l’ensemble des dispositifs de prévention mis en place par les différents acteurs. Nous présentons les dispositifs de communication collaborative proposés par les designers et celui qui a été retenu et qui sera prototypé et expérimenté en 2023. Cette recherche est également l’occasion de présenter le modèle ECoPI (Engagement, Compétence, Performance, Bilan), qui correspond à la description du parcours transactionnel associé à l’enquête et du modèle DIPE (Définition, Idéation, Prototypage, Évaluation) qui correspond à une déclinaison du parcours transactionnel ECoPI à l’approche transactionnelle du design. Ces modèles contribuent à l’opérationnalisation de la sémiotique des transactions coopératives dans le cadre d’études de terrain.
Facteurs de protection en temps de guerre, implications pédopsychiatriques
Authors: Ionescu Serban
Published: August 2023

La guerre est une situation d’urgence humanitaire causée par des personnes, ayant des effets néfastes sur la santé physique et mentale. Ces effets sont plus importants chez les enfants en raison de leur dépendance physique et sociale. Pour eux, la guerre représente une perturbation majeure de l’écologie sociale – avec une détérioration, notamment, de la vie familiale et du fonctionnement des institutions éducatives et sanitaires – institutions essentielles à leur bon développement mental et physique. Les chercheurs et les cliniciens dans le domaine de la psychiatrie et de la psychologie clinique se sont penchés sur les problèmes de santé mentale des enfants et des adolescents touchés par la guerre, en se concentrant principalement sur les facteurs de risque et les troubles mentaux causés par les situations de guerre. La présente étude est consacrée aux facteurs de protection – individuels, familiaux et environnementaux – dont l’efficacité a été démontrée.
L’ open data dans les recherches participatives : partager les connaissances tout en stimulant les échanges
Authors: Peres Juliette
Published: August 2023

Comment une association souhaitant mettre à disposition les connaissances produites dans ses recherches participatives peut-elle concevoir un projet d’ open data au service de la communauté ? En réponse à cette question qui occupe de plus en plus d’associations, Juliette Peres invite dans cet article à reconsidérer les pratiques, étape après étape, à partir du projet d’ open data sur les céréales locales de l’association FAB’LIM. Dans un contexte pouvant être perçu comme concurrentiel, c’est tout à la fois le mode de production, d’archivage, de gestion et de partage des données, mais aussi la place de la communauté dans la création et la modération des contenus ainsi que la pérennisation de ces actions qui doivent être repensés.
Déméter et Koré, héroïnes de mythological fantasy
Authors: Briand Michel
Published: August 2023

Ursula Le Guin, réinventant des récits mythologiques et épiques (par exemple Lavinia , 2008) inspire des pensées et fictions écoféministes et queer , antipatriarcales et anarchistes. Après avoir revu les figurations anciennes de Déméter et Koré, on observe ici comment elles sont centrales en particulier dans deux de ses textes : Her Silent Daughter (1994), poème de mythological fantasy , et le psychomythe Kore 87. A Child Bride (1996). Le lien mère/fille ainsi que leur rapport au monde sont des moteurs d'intrigue dans ces fictions spéculatives qui, par une satire pathétique, dénoncent la violence patriarcale et économique. Cet artivisme textuel dérègle aussi les binarismes académique/populaire, fiction/réalisme ou littérature/anthropologie.
L’exercice de la parentalité en espace de rencontre. Conditions et limites de l’usage d’un dispositif socio-judiciaire
Authors: Morange Arnaud
Published: August 2023

Le présent article est le fruit d’une recherche qualitative auprès de l’ensemble des acteurs concernés par le dispositif « Espace de rencontre » ( er ) en France. Ce dispositif tant judiciaire que répondant aux nouvelles aspirations sociales autour de la famille vient soutenir le lien parent-enfant dans le cadre de séparations conflictuelles ou en cas d’incapacité de l’un des parents d’accueillir son ou ses enfants. Cette recherche, conduite entre 2017 et 2020 au sein de douze structures, visait à mieux appréhender les pratiques en er , à identifier tant l’intérêt que les limites du dispositif et à faire émerger de nouveaux questionnements sur le maintien des liens filiaux dans des situations complexes. Le vécu des parents, enfants et professionnels concernés y a été recueilli par des chercheurs issus des sciences humaines et sociales. Si cette mesure socio-judiciaire est bien admise par une majorité des usagers, la manière dont les enfants, eux, vivent les rencontres reste questionnante.
Les aliments transformés peuvent-ils être réellement bio ? Le point de vue des consommateurs
Authors: Fartsi Ida , Dufeu Ivan , Briand-Decré Gwenaëlle , Travers Muriel , Appéré Gildas
Published: August 2023

• Objectif Le règlement public du label européen de production biologique, qui introduit des principes applicables à la transformation biologique en général, présente plusieurs faiblesses : l’une d’elles est que la compatibilité entre procédés de transformation et principes du bio a été appréciée sous l’angle des sciences de l’aliment, le point de vue des consommateurs ayant été peu considéré. La présente recherche a pour objectif d’étudier les attentes des consommateurs à l’égard des procédés de transformation en bio, ce qui, dans un contexte d’information très imparfaite, nécessite de saisir leurs représentations. Comment les consommateurs se représentent-ils une transformation dans le cas de produits bio ? • Méthodologie L’analyse de trente entretiens semi-directifs offre des clés de lecture conceptuelle des critères que convoquent les consommateurs pour apprécier dans quelle mesure un aliment transformé peut être qualifié de bio. • Résultats Sans surprise, la naturalité ressort comme étant une dimension transversale importante. Mais le résultat nouveau est la mise en évidence de l’écart entre l’attention des sciences de l’aliment, portée essentiellement sur les effets de la transformation sur la naturalité, et l’attention des consommateurs, portée essentiellement sur la naturalité des procédés eux-mêmes ainsi que sur leur finalité. • Implications managériales Ce résultat pourrait inciter des marques à renoncer à certaines technologies, fussent-elles désirables sur un plan biochimique ou fonctionnel. • Originalité La recherche montre que la manière dont les consommateurs se représentent la transformation alimentaire n’est pas la même selon qu’il s’agisse de produits bio ou de produits conventionnels. Un champ de recherche est donc ouvert.
La relation bancaire : un atout pour le financement des petites et moyennes entreprises françaises en situation de crise
Authors: Coffinet Jérôme , Nicolas Théo
Published: August 2023

Le crédit aux entreprises constitue une source primordiale de financement des petites et moyennes entreprises (PME) et des très petites entreprises (TPE) en France, dont il constitue l’essentiel des ressources. Au cours des récentes crises (crise des subprimes , crise des dettes souveraines, crise sanitaire, invasion de l’Ukraine), au-delà des dispositifs exceptionnels mis en place, le crédit aux entreprises s’est révélé robuste. Il constitue de ce fait un atout majeur de résilience de l’économie. Cet article met en lumière une particularité du financement des PME en France, à savoir l’importance du crédit relationnel, caractérisé par un faible nombre de relations bancaires par entreprise et l’exclusivité du partage des informations. S’il est susceptible d’accroître les coûts de financement en période d’expansion, il permet surtout de les réduire significativement en période de crise. Les bénéfices attendus pourraient être accrus par le développement de conditions davantage concurrentielles. Classification JEL : E03, E50, G21, G32 .