bluuebunny/crossref_metadata_2025 huggingface dataset:
Peculiarities of Formation and Changes in the Rate of Tuberculosis Mortality in Altai Kray over Thirty-Year Period from 1991 to 2020
Authors: Smetanina E. A. , Smetanin A. G.
Published: March 2022

The objective: to study the long-term changes (1991-2020) in tuberculosis mortality in population of Altai Kray and assess the impact of certain categories of citizens on the formation of this rate.

Subjects and Methods: Statistical Forms no. 8, 30, and 33, statistical compilations, and medical scientific publications.

Results. In order to analyze the curves reflecting changes in tuberculosis mortality in Altai Kray and Russia, these curves have been divided into three conventional periods. General trends have been identified but there are some peculiarities: a significant excess of the average longterm value of the rate versus this rate for whole of Russia; this rate increased faster in the conventional period of 1991-2005. Using the statistical method, it has been established that the formation of tuberculosis mortality rate in the population of Altai Kray was influenced by tuberculosis mortality rate in the Federal Penitentiary Service in 1997 and 1998 and in homeless people in 2005-2008.
Specific Features of Diagnosis, Clinical Course and Treatment of Tuberculosis Pericarditis
Authors: Velikаya O. V. , Khoroshilovа N. E. , Lushnikovа A. V. , Prokushev R. Yu.
Published: March 2022

The article describes a clinical case of tuberculosis pericarditis in a patient with disseminated pulmonary tuberculosis. X-ray examination of the patient revealed a significant increase in the size of the heart shadow, some fluid in the pericardium up to 1 liter was visualized. The etiology of the disorder was verified by detection of Mycobacterium tuberculosis (MTB) by pericardial fluid culture, and drug sensitivity testing of MTB was performed. Thus an effective treatment regimen was developed, tuberculosis pericarditis and disseminated pulmonary tuberculosis were cured. Echo-CG was used for diagnosis and monitoring of the course of tuberculosis pericarditis.
A brief introduction to extended gravity and connections to dark energy: Illustrated with scalar field examples
Authors: Burrage Clare
Published: March 2022

These lecture notes provide a brief introduction to extensions of gravity and their connections to dark energy. Due to time and space limitations this is not a comprehensive review of the field. Instead, I aim to introduce key concepts and ideas in this area through a series of examples based on scalar field extensions of gravity and models of dark energy.
Actualization of the issues of effective external therapy of microbial eczema: description of clinical cases
Authors: Silina L. V.
Published: March 2022

The present study discusses the etiopathogenetic theories of the occurrence of eczema – a chronic recurrent allergic skin disease often encountered in the practice of a dermatovenerologist, formed under the influence of exogenous and endogenous trigger factors, characterized by the appearance of polymorphic rash, inflammatory reaction, disorders of various systems and organs that contribute to the debut or examination of the pathological process. Among the causal influences, various exogenous factors are also noted: infectious agents – resident and transit symbionts – bacteria and fungi, viruses, as well as physical and chemical direct and indirect effects, food products, some medicines. a variety of immunological disorders are described, a modern classification of eczema with the isolation of clinical forms is indicated, a description of the clinical stage-by-stage course of eczema, features of efflorescence in acute and chronic eczema and their variants of evolution in various clinical cases the standard treatment regimens are considered – the appointment of general-acting drugs and local dosage forms. We have described in this publication various clinical cases of treatment of patients suffering from chronic microbial eczema, against the background of their somatic health or with comorbid burden using traditional therapy regimens with the inclusion of combined external agents containing a corticosteroid, an antibiotic and an antimycotic, in accordance with clinical recommendations. All patients at the end of the course of prescribed therapy noted a significant improvement in the form of almost complete relief of erythema, significant leveling of itching, disappearance of wetness, the presence of papular and papulovesicular rashes and manifestations of infiltration, peeling and lichenization of the affected areas of the dermis.
Diapason of concomitant diseases in children with psoriasis
Authors: Valiev A. A. , Khaitov K. N. , Turdieva Sh. T.
Published: March 2022

Introduction. Psoriasis is a common chronic immune-mediated inflammatory disease that affects the skin, nails, and joints. Despite the presence of many scientific and clinical studies, the problem of the prevalence of concomitant pathology in children with psoriasis, depending on the age category, remains poorly understood.

Objective. Study of the type and frequency of detection of concomitant diseases in children and adolescents with psoriasis, depending on the age category.

Materials and methods. Were examined 68 children with psoriasis from 5 to 18 years old, of both sexes, receiving treatment in a multidisciplinary clinic at the clinic of the Tashkent Pediatric Medical Institute. Anamnestic data were studied, general clinical studies were carried out, including biochemical and hormonal studies, depending on the type of concomitant pathology.

Results. Studies have shown that most often concomitant diseases in psoriasis in children are characteristic of the adolescent group of patients, and the most common diseases were endocrine diseases (61.8%) in combination with metabolic disorders in the form of obesity of varying degrees (22.06%) and hyperlipidemia (16.2%). At the same time, in adolescents, the incidence of thyroid pathology is 1.7 times higher than in children from the younger age group, against the background of a high incidence of chronic diseases of the upper digestive tract (28.9% versus 17.4%). At the same time, malabsorption syndrome was more typical for children of the younger age group (13% versus 4.4%).

Conclusion. The most common concomitant diseases are endocrine pathology (61.8%) against the background of metabolic disorders (38.2%), as well as chronic diseases of the gastrointestinal tract (25%), and the incidence of these pathologies increases with the age of children. These facts should be taken into account when carrying out complex medical and recreational work with these patients in an outpatient setting.
The role of vitamin D in the prevention of pathology associated with psoriasis and metabolic syndrome
Authors: Matushevskaya E. V. , Komissarenko I. A. , Vladimirova E. V. , Matushevskaya Yu. I. , Konev Yu. V. , Levchenko S. V.
Published: March 2022

The paper highlights modern views on the metabolism of vitamin D in the human body. The analysis of the literature data on the mechanisms of the effect of vitamin D deficiency on the pathological processes occurring in the skin with psoriasis is carried out. It is known that psoriasis is associated with a high prevalence of metabolic syndrome, diabetes mellitus, and cardiovascular diseases. There is a direct correlation between a decrease in vitamin D levels and an increased risk of developing metabolic syndrome and cardiovascular mortality, including in patients with psoriasis. Data on the possibility of using vitamin D in dermatology are presented. Based on international and Russian clinical recommendations, the place of oral colecalciferol preparations in the prevention and correction of vitamin D deficiency and deficiency has been determined. The use of oral vitamin D for the simultaneous treatment of psoriasis and metabolic syndrome reduces the risk of cardiovascular diseases and type 2 diabetes mellitus. We analysed the international and domestic recommendations for the treatment of vitamin D deficiency and insufficiency, the use of which makes the oral administration of vitamin D3 (cholecalciferol) optimal for the treatment and prevention of vitamin D deficiency, as the results of several studies showed a higher efficacy of vitamin D3 vs vitamin D2. Vitamin D3 is found in vitamin D-fortified foods and is available as dietary supplements and drugs. The bioavailability of vitamin D in dietary supplements may differ depending on the used vehicle substance.
Management of the post-procedural period in aesthetic medicine – prevention of complications and reduction of the rehabilitation period
Authors: Ostretsova M. N. , Korenevska A. , Kasikhina E. I. , Ismatullaeva S. S.
Published: March 2022

The post-treatment period plays a great role in the prevention of complications and shortens the rehabilitation time. The article provides up-to-date international statistics on the number of cosmetic procedures performed annually according to the International Society for Aesthetic and Plastic Surgery (ISAPS). A successful clinical experience of using a repair cream con taining oat plantlets extract, l-ALA-l-GLU dipeptide and hyaluronic acid as post-procedure care on the example of 2 patients is described. In the first case, a 32-year-old patient presented with postacne scars underwent a fractional radiofrequency ablation procedure followed by application of a cream with oat plantlets extract on the left side of the face, and a cream with dexpanthenol on the right side for 10 days. 5 minutes after application on the left side, the patient noted a pronounced reduction in burning, tingling, itching and soreness sensation. The entire post-treatment period also was faster and more comfortable on the side of the face, where the cream with oat plantlets extract was applied and ended successfully by the 8th day after the procedure. On the comparison side, the full rehabilitation process took 10 days. In the second case, a 27-year-old patient with acne, after a chemical peeling procedure, as a final remedy and further post-procedure care used the cream with oat plantlets extract on one side of the face, and a cream recommended by the manufacturer of peeling systems on the other side. When re-examined after 7 days, there was also a faster regression of inflammatory elements, post-procedural erythema and edema, dryness and discomfort after peeling were less pronounced on the side of the face where the cream with oat plantlets extract was applied. Repair cream containing oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid showed excellent efficacy and tolerability, had synergistic efficacy (moisturizing, healing, preventing aesthetic defects). The authors consider to recommend it as a mean of post-procedural rehabilitation.
Chemistry Underlying the Cardiotoxicity of Antihistaminest
Authors: Zhang Ming-Qiang
Published: March 2022

Antihistamines are very useful therapeutic agents for the treatment of allergic diseases, and are one of the most frequently prescribed medicines world-wide. Despite the excellent safety record of antihistamines, the recent reports on cardiac toxicity associated with the use of antihistamines have caused wide-spread concerns among both the scientific community and the general public. This review delineates the molecular factors underlying this potentially devastating side effect of the otherwise .
very safe therapeutics, including their pharmacodynamic activities on car d1ac potass1um channels and pharmacokinetic interactions with other therapeutic agents. The discussion is mainly based on structure-activity relationship of these agents and their cardiotoxicity, so to predict and prevent potential therapeutic hazards. Implications for future drug development as well as rational use of other therapeutic agents are also discussed.
Sialic Acids and Sialic Acid-Recognising Proteins: Drug Discovery Targets and Potential Glycopharmaceuticals
Authors: von ltzstein M. , Thomson R. J.
Published: March 2022

Sialic acids, and the proteins and enzymes which utilise them, are increasingly becoming recognised as playing pivotal roles in a variety of disease states, including microbial infection, inflammation and some cancers. This article reviews aspects of sialic acid biology and chemistry with relation to their biological functions and, in the case of influenza virus infection, details work towards the development of potential therapeutic agents.
Optimization of the Properties of Brain Specific Chemical Delivery Systems by Structural Modifications*
Authors: Pop Emil
Published: March 2022

Several properties of 1,4-dihydropyridine pyridinium salt redox targetor-based brain specific chemical delivery systems (CDS), important for the efficient transport of xenobiotics to the brain, including lipophilicity, oxidative and hydrolytic stability and resistance to hydration can be influenced, modified and optimized by appropriate structural changes. These modifications which address the targetor and its linkage with the drug
can be quite diverse and specific to particular properties. A higher lipophilicity of CDSs can be
achieved, for example, by increasing the length of the N-alkyl substituent of the 1,4-dihydropyridine moiety, by employing a dihydroisoquinoline- type carrier or by using complex linkages and spacers. The hydrolytic stability is dependant mainly on the type of linkage · between targetor and drug (ester, amide, carbamate, substituted carbamate, glycol diester, etc) while the stability toward oxidation and hydration are dependant on targeter and its substituents and type of linkage. Numerous examples of structural variations and their effect on properties of CDSs are given. Theoretical support, generated by molecular orbital calculations, is provided for some of these practical observations. Data presented are useful for the rational design of CDSs

*Presented at the 1-St Drug Optimization via Retrometabolism Conference, Amelia Island
Plantation, FL, May 6-9, 1997.
Second Generation Antimigraine S-Ht1BID Agonists: Structure Activity Relationship and Preclinical Pharmacological Distinctions
Authors: Yevich Joseph P. , Yocca Frank D.
Published: March 2022

The discovery and development of the 5-HT1810 agonist sumatriptan for alleviating migraine pain has been an important advance in the field of modern headache treatment and research. This important therapeutic advance is not without it's shortcomings. When administered orally, it is poorly absorbed with clinically relevant headache relief occurring at least two hours after drug administration. Due to its agonist action at peripherovascular 5-HT1D-Iike
receptors, it is contraindicated in patients with coronary artery disease. Furthermore, headache recurs within a 24 hour period in 40% of patients treated. Given the large unmet medical need, market size and sumatriptan's shortcomings, a number of second-generation agents have been developed which are structurally and pharmacologically similar to sumatriptan, but have improved oral pharmacokinetic profiles. These include zolmitriptan, naratriptan, rizatriptan, avitriptan, alniditan, eletriptan and BMS-181885, all of which have been shown to be clinically effective. In this review, the SAR of the second-generation triptans at the 5-HT 18 and 5-HT10 receptors as well as distinct pharmacological actions in novel animal models are discussed.
Lexitropsin Conjugates: Action on DNA Targets
Authors: Sondhi S.M. , Reddy B.S. Praveen , Lawn J.W.
Published: March 2022

Lexitropsins have been combined with epipodophyllotoxin, aromatic and aliphatic phosphonated and sulfonated compounds, bithiazoles, oligodeoxy-ribonucleotides, pyridine, imidazole, decazadecabutylamine, acridines, anthraquinones, pyrene, ellipticine, oxazolopyridocarbazole, porphyrin, nitrosoureas, benzoyl mustards, nitrogen mustards, CC-1065, psoralens, bleomycin, flavins, metal chelating moieties, enediynes, and propargyl sulfones to give the corresponding lexitropsin conjugates. In most of the cases each of the individual components of the lexitropsin conjugate retain their modes of action as far as
interaction with DNA is concerned. In some cases the components of the lexitropsin conjugates altered their mode of interaction towards DNA or developed new properties. Alkyl alkanesulfonate esters are major groove alkylators. After formation of lexitropsin conjugates they become minor groove alkylators. A-T specific netropsin and distamycin accept G-C sites after forming conjugates with pyridine. CI-ENU breaks DNA after alkylation at N7 of guanine whereas its lexitropsin conjugate cleaves at A and T residues associated with affinity binding sites. Benzoyl mustard changes from a major groove alkylator (N7 of guanine) to a minor groove alkylator (adenine) after formation of lexitropsin conjugates. Epipodophyllotoxin conjugates with lexitropsins have additional sites available for topoisomerase II cleavage compared with the unconjugated agent. Thermal stability of oligodeoxynucleotides is increased after formation of a lexitropsin conjugate. In the case of lexitropsin acridine conjugates the binding of one component is compatible with DNA binding of the other component. The A-T specificity of a netropsin-oxazolopyridocarbozole conjugate is much less as compared to netropsin. Lexitropsin-psoralen conjugates bind more tightly at A-T sites of DNA compared with the individual components. The relative rate of DNA cleavage is increased with increase in the number of N-methylpyrrole units in lexitropsin-bleomycin conjugates. Phosphonated-sulfonated lexitropsin conjugates are highly active against HIV and may prove valuable for the treatment of AIDS. The benzoyl mustard-lexitropsin conjugate, i.e., FCE-24517, shows broad spectrum anticancer activity and is undergoing clinical evaluation.
Rational Development of New Sleeping Sickness Drugs
Authors: Van Calenbergh Serge , Herdewijn Piet
Published: March 2022

Narrow activity spectrum and toxicological considerations are major shortcomings of the current therapeutics used for the treatment of sleeping sickness. During the last decennial rational drug design approaches have entered the field and have opened new horizons for the future treatment of Trypanosoma infections. This short review summarizes the present status of antitrypanosomal rational drug design with special focuss on gGAP[)H as worked out in the authors' laboratory.
Migraine: Current Drug Discovery Trend
Authors: Meng Charles  Q.
Published: March 2022

Migraine is a common disorder severely affecting normal life. There is no perfect treatment for it to date. Sumatriptah is the first, antimigraine drug developed, through contemporary medicinal chemistry.· Since sumatriptan binds with high affinity to 5-HT1Da, 5-HT1Db and 5-HT1F
receptors it has been proposed that one or more of these receptor sub types is involved in the
pathophysiology of migraine. It is almost certain that the 5-HT1D receptor causes the cardiac adverse reactions of sumatriptan.

Several compounds are currently under clinical development or about to reach the market for the treatment of migraine. However, most of them are structurally similar to sumatriptan, bind to the 5- HT10 receptor and therefore have potential cardiac adverse reactions. An obvious advantage of some of the compounds over sumatriptan is the higher oral bioavailability than sumatriptan. Some penetrate the CNS whereas sumatriptan does not. It remains to be seen whether CNS penetration is beneficial.

Vascular and neurogenic mechanisms have -been proposed for migraine. Both theories are backed up by scientific data and countered by controversies.

Selective ligands at the respective 5-HT 1Da· 5-HT1D and 5-HT1F rceptors will possibly provide not only scientific tools for migraine research but also satisfactory antimigraine drugs.
Interaction of the Antitumor Antibiotic Streptonigrin with Metal Ions and DNA
Authors: Long Georgina V. , Harding Margaret M.
Published: March 2022

Streptonigrin is a functionalized 7-aminoquinoline-5,8-dione that is highly active against a range of human cancers. While streptonigrin was in clinical use until 1977, the mechanism of antitumor action of the drug was only investigated in detail after clinical trials were discontinued. In common with other aminoquinone antitumor antibiotics, extensive studies suggest that streptonigrin exerts its antitumor activity by causing DNA strand scission.
Metal ions were identified as serving a key role in both the DNA-degradation pathway, either by direct complexation with streptonigrin or reduced streptonigrin and/or catalysing the production of the DNA damaging species, and in enhancing the interaction of the drug with ccc-DNA and calf thymus DNA. While streptonigrin itself interacts only very weakly with DNA, this interaction is strongly enhanced when the drug is reductively activated or in the presence of transition metal ions.

This review will cover the literature reported since 1985. Important results that have been recently reported include the solution conformation of the drug, structures of the metal complexes of streptonigrin, characterisation of streptonigrin semiquinone, DNA-footprinting and key structure-activity studies. These reports have clarified some of the mechanistic aspects of streptonigrin-mediated DNA cleavage and provide a basis for rational drug design of streptonigrin analogues with modified therapeutic properties and side effects.
Peptidic and Non-peptidic Neurotensin Analogs
Authors: Cusack Bernadette , Hong Feng , Fauq Abdul , Richelson Elliott
Published: March 2022

The structure-activity relationship studies of neurotensin and its analogs have revealed that i) the C-terminal hexapeptide NT (8-13) (H-ArgB­
Arg9-Pro1o_Tyr1LIIe12-Leu13.QH) is equipotent to or more potent than the
native NT(1-13) and retains all the intrinsic biological properties of neurotensin, ii) the N-terminal peptide fragment up to NT(1-7) does not significantly contribute to the binding potency, iii) Pro1o that can form a reverse-turn conformation is required, iv) an aromatic amino acid is important at
Tyr11 position, v) the lipophilic side chain of Leu 13 is also crucial to the biological activities, and, vi)
L-form amino acids are essential at critical positions for the binding potency. In addition to many peptidic neurotensin analogs, highly potent, orally active, and selective non-peptidic analogs as antagonists of NT receptors, which have long lasting effects and the ability to cross the blood­ brain barrier (e. g. SR 142948 A and SR 48692), have been discovered.
Applications of Solid-Phase Synthesis to Drug Discovery
Authors: Cowley Phillip M. , Rees David C.
Published: March 2022

This review aims to highlight the opportunities for the utilisation of solid-phase synthesis in the process of drug discovery. The two main sections discuss the preparation and biological testing of compound libraries and the preparation of compound arrays based around approved drugs. Biologically active compounds in assays for enzyme inhibition, membrane­ bound protein ligands and intracellular hormone receptors are discussed, illustrating the power of this relatively new tool in the arena of medicinal chemistry.
Manipulationism and causal exclusion
Authors: PEXTON Mark
Published: March 2022

A new way of avoiding the causal exclusion argument in the context of manipulationism is proposed. In manipulationism, causal explanations are defined by counterfactual information accessed through manipulations. It is argued that the property of manipulability can be an emergent property of aggregate systems. Therefore, some causal explanations are non-reducible and causal exclusion is avoided. This emergentist notion of causal explanation addresses the question of how the special sciences can be based upon causal reasoning, even if fundamental physics is absent of causal relations.
Measurement of Vital Signs Using Lifelight® Remote Photoplethysmography: results of the VISION-D and VISION-V observational studies (Preprint)
Authors: Heiden Emily , Jones Tom , Brogaard Maczka Annika , Kapoor Melissa , Chauhan Milan , Wiffen Laura , Barham Helen , Holland Jeremy , Saxena Manish , Wegerif Simon , Brown Thomas , Lomax Mitch , Massey Heather , Rostami Shahin , Pearce Laurence , Chauhan Anoop
Published: March 2022

BACKGROUND

Detection of early changes in vital signs (VS) enables timely intervention; however, measurement of VS requires hands-on technical expertise and is often time-consuming. Contactless measurement of VS is beneficial to prevent infection, such as during the COVID-19 pandemic. Lifelight® is a novel software being developed to measure VS by remote photoplethysmography, based on video capture of the face via the integral camera on mobile phones and tablets. We report the observational VISION-D data collection study for algorithm development (NCT04763746) and VISION-V (NCT03998098), a laboratory-based validation study of Lifelight.

OBJECTIVE

Data collection for algorithm development (VISION D) and software validation (VISION V)

METHODS

Blood pressure (BP), pulse rate (PR), and respiratory rate (RR) were measured simultaneously using Lifelight, a sphygmomanometer (BP, PR) and manual counting of RR. Accuracy performance targets for each VS were defined from a systematic literature review of the performance of state-of-the-art VS technologies.

RESULTS

The VISION-D dataset (17,233 measurements from 8585 participants) met the accuracy targets for RR (0.3 ± 3.6 [mean error ± SD] vs target of 2.3 ± 5.0; n=7462), PR (0.3 ± 4.0 vs 2.2 ± 9.2; n=10,214), and diastolic BP (−0.4 ± 8.5 vs 5.5 ± 8.9; n=8951); for systolic BP, mean error target was met but not SD (3.5 ± 16.8 vs 6.7 ± 15.3; n=9233). Fitzpatrick skin type did not affect accuracy. The VISION-V dataset (679 measurements from 127 participants) met all the standards: −0.1 ± 3.4 for RR; 1.4 ± 3.8 for PR; 2.8 ± 14.5 for systolic BP; −0.3 ± 7.0 for diastolic BP.

CONCLUSIONS

Lifelight demonstrates sufficient accuracy in the measurement of VS, particularly RR and PR, which are important early indicators of clinical deterioration. As use of Lifelight does not require specific training or equipment, the software is potentially useful for the contactless measurement of VS by non-clinical staff in residential and home care settings.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/14326
Assessing the Views and Needs of People at High Risk of Gestational Diabetes Mellitus for the Development of Mobile Health Apps: Descriptive Qualitative Study (Preprint)
Authors: Duan Beibei , Liu Zhe , Liu Weiwei , Gou Baohua
Published: March 2022

BACKGROUND

Early prevention of gestational diabetes mellitus (GDM) can reduce the incidence of not only GDM, but also adverse perinatal pregnancy outcomes. Moreover, it is of great significance to prevent or reduce the occurrence of type 2 diabetes. Mobile health (mHealth) apps can help pregnant women effectively prevent GDM by providing risk prediction, lifestyle support, peer support, professional support, and other functions. Before designing mHealth apps, developers must understand the views and needs of pregnant women, and closely combine users’ needs to develop app functions, in order to better improve user experience and increase the usage rate of these apps in the future.

OBJECTIVE

The objective of this study was to understand the views of the high-risk population of gestational diabetes mellitus on the development of mobile health apps and the demand for app functions, so as to provide a basis for the development of gestational diabetes mellitus prevention apps.

METHODS

Fifteen pregnant women with at least one risk factor for gestational diabetes were recruited from July to September 2021, and were interviewed via a semistructured interview using the purpose sampling method. The transcribed data were analyzed by the traditional content analysis method, and themes were extracted.

RESULTS

Respondents wanted to develop user-friendly and fully functional mobile apps for the prevention of gestational diabetes mellitus. Pregnant women's requirements for app function development include: personalized customization, accurate information support, interactive design, practical tool support, visual presentation, convenient professional support, peer support, reasonable reminder function, appropriate maternal and infant auxiliary function, and differentiated incentive function.These function settings can encourage pregnant women to improve or maintain healthy living habits during their use of the app

CONCLUSIONS

This study discusses the functional requirements of target users for gestational diabetes mellitus prevention apps, which can provide reference for the development of future applications.
Correction: Ascertaining Medication Use and Patient-Reported Outcomes via an App and Exploring Gamification in Patients With Multiple Sclerosis Treated With Interferon β-1b: Observational Study (Preprint)
Authors: Limmroth Volker , Bayer-Gersmann Kirsten , Mueller Christian , Schürks Markus
Published: March 2022

UNSTRUCTURED

N/A
Ефективність та безпека Церебролізину після неефективної реканалізації у пацієнтів із тяжким інсультом
Authors: Poljakovic Z. , Supe S. , Ljevak J. , Starcevic K. , Peric I. , Blazevic N. , Krbot-Skoric M. , Jovanovic I. , Ozretic D.
Published: March 2022

Актуальність. Золотим стандартом лікування гострого інсульту є реканалізаційна терапія. Однак відновлення прохідності закупореної кровоносної судини іноді не дає очікуваного клінічного результату або призводить до геморагічних ускладнень. Оскільки нейрозапалення та нейротоксичність відіграють важливу роль у патофізіології інсульту, у збереженні тканини мозку після неефективної реканалізації можуть допомогти нейропротекторні препарати. Матеріали та методи. Після проведення реканалізації та не пізніше ніж через 24 години після появи симптомів пацієнти з початковим показником NIHSS > 8 були розподілені у досліджувану та контрольну групи. Досліджувана група як додаткову терапію отримувала внутрішньовенно Церебролізин. Первинною метою була оцінка клінічної ефективності Церебролізину. Вторинною — дослідити його вплив на геморагічну трансформацію та підтвердити профіль його безпеки. Результати. Вихідні характеристики пацієнтів не продемонстрували вірогідних відмінностей між двома групами. Не вдалося виявити різниці між двома групами за шкалою mRS, хоча в групі застосування Церебролізину була наявна перевага над контрольною групою. Ми виявили статистично вірогідну різницю щодо геморагічної трансформації та рівня смертності на користь групи Церебролізину. Мультимодальний нейротрофічний засіб Церебролізин впливає на пізні наслідки реперфузійного синдрому. Його вплив на зменшення нейрозапалення, підвищення життєздатності нейрональних клітин і нейрогенезу, а також стабілізуючий ефект на гематоенцефалічний бар’єр свідчать про захисну дію на нервово-судинну одиницю, навіть якщо реканалізація не відбувається. Підтверджено відмінний профіль безпеки Церебролізину. Висновки. Церебролізин як додаткова терапія є корисним і безпечним засобом для застосування у пацієнтів із гострим інсультом з точки зору зниження ризику геморагічних ускладнень після реканалізації.
Оновлена інформація про менінгіоми крила клиноподібної кістки
Authors: Nassar Abdalrahman , Smolanka Volodymyr
Published: March 2022

Менінгіоми є найбільш поширеними негліальними внутрішньочерепними пухлинами в дорослих, на частку яких припадає 14–19 % від усіх первинних внутрішньочерепних пухлин і які найчастіше зустрічаються в жінок. Вони є найбільш поширеними пухлинами крила клиноподібної кістки, становлять 15–20 % від усіх внутрішньочерепних менінгіом, являють собою третю за поширеністю групу внутрішньочерепних менінгіом. Більшість менінгіом крила клиноподібної кістки відносно легко видалити; однак іноді вони становлять труднощі у зв’язку з їх проникненням в кавернозний синус, кістку і, особливо, через їхній тісний зв’язок з магістральними артеріями і черепно-мозковими нервами. У цих випадках повне висічення надзвичайно утруднене, що призводить до високої захворюваності та високої частоти повторного зростання або рецидиву [1–4]. У цій статті ми розглядаємо сучасні концепції діагностики, лікування та подальшого спостереження з урахуванням прийняття клінічних рішень, що ґрунтуються на даних мультимодальної візуалізації та молекулярної біології.
Досвід застосування досягнень хрономедицини у комплексній реабілітації неврологічних хворих
Authors: Sidelkovskiy A.L.
Published: March 2022

Жива матерія протягом мільйонів років існує в умовах ритмічних змін геофізичних параметрів навколишнього середовища, і кожна фізіологічна реакція, будь-яке біологічне явище має свою, властиву тільки йому унікальну періодичність. Порушення гармонії ритмічних процесів в організмі людини призводить до неузгодженості регуляторних фізіологічних механізмів і, як наслідок, до розладів його індивідуальних біоритмів. Біологічні ритми є найважливішими механізмами регуляції різних функцій організму, що забезпечують гомеостаз та адаптацію людини до зовнішнього середовища. Останнім часом інтерес до хрономедицини значно зріс через відкриття практичного застосування знань про біоритми та їх порушення (десинхроноз). Добові коливання характерні для роботи практично всіх органів і систем: серцево-судинної, дихальної, травної, видільної. Циркадіанні коливання роботи цих систем багато в чому визначаються станом вегетативної нервової системи й ендокринних залоз. Момент народження кожної людини визначає синхронізацію унікальних, індивідуальних біологічних ритмів. Індивідуальні біоритми збігаються з днем народження людини і перебувають під впливом сонячної активності, положення планет, Місяця, зірок та ін. Призначення ліків як з профілактичною, так і з лікувальною метою має здійснюватись в обов’язковому порядку з урахуванням біоритмів пацієнта. Хворобливі стани формують власні ритми, що негативно впливають на стан пацієнта.
How can the Public Relations Increase Brand Awareness
Authors: Yanqiu Zhao , Chuan Lin
Published: March 2022

The central idea of this paper is to explore the relationship between public relations and brand Awareness. In order to clarify the relationship between them, the paper uses the following method: On the basis of previous theories, clarify relevant definitions, and then give examples to illustrate the relationship between public relations and brand awareness. Finally, explain the result that public relations can act as Brand Awareness Booster in some circumstances.
Fighting the Demographic Winter—An Evaluation of Hungarian Family Policy for the Last Ten Years
Authors: Novoszáth Péter
Published: March 2022

These days as well as the past decades, the demographic relationship between European countries is best characterized by low fertility rates and the resulting aging population and low birth rates. Members of the European Union, including Hungary are faced with similar issues in the stagnation and decrease in the number of births and the fact that the total fertility rate does not meet the 2.1-value necessary for a population’s reproduction. The European Union does not have a family policy and member states have different needs on a national level. Each country uses various methods to combat the challenges resulting from a “demographic winter” based on their own cultural background and financial capacities. This study examines the increase in fertility rate in Hungary between from 2010 to 2019 which occurred despite the fact that women tend to have their first child at an increasingly older age. As a result of Hungarian family policy, the fertility rate in Hungary increased from 1.25 to 1.55 during the past decade. In my study I’m going to examine the actions that led to this. This study will also give credence to the fact that a coherent family policy can have positive effects on demographic processes.
Graph Based Personalized Travel Recommendation Using Data Mining Technique Collaborative Filtering Algorithm
Authors: Deshmukh Miss. Samradni , Ingole Prof. K. R.
Published: March 2022

Abstract: The recommendation system has growth choices in recent years. The recommendation system is exist in many applications which gives online travel information for individual travel package. A new model named travel recommendation using data mining techniques which extracts the features like locations, travel seasons of various landscapes. Thus it possesses the material of the travel packages and interests of tourists. Further extending E-TRAST model with the tourist-relation-area season topic model includes relationship with tourists. It includes mining significant tourist locations based on the user search trajectories of users on web and also derives a personalized travel algorithm recommendation system using travelogues and users contributed photos with metadata of this photo by comparing existing different technique. To suggest personalized POI sequence, first famous routes are stratified as per the similarity between user package and route package. Keywords: Travel package, recommender systems, cocktail, topic modeling, and collaborative filtering
Analisis Tingkat Kepuasan Konsumen Memilih Air Yang Layak Minum Dalam Kemasan Galon Dengan Metode ANP
Authors: Azhar Asbon Hendra , Destari Ratih Adinda
Published: March 2022

Penggunaan akan air minum dalam kemasan galon pada konsumen pada saat ini di Indonesia sangat meningkat. Setiap hari konsumen membutuhkan air minum yang sehat dan tentunya sangat mudah didapat serta terjangkau harganya. Belum lagi pada saat ini sangat sulit untuk mendapatkan produk air minum dalam kemasan galon yang benar-benar sudah memenuhi standart kesehatan yang sudah ditetapkan. Untuk itu diperlukan suatu solusi dalam mendapatkan prioritas air minum dalam kemasan galon yang terjangkau dan hasil yang diharapkan bisa memenuhi target yang diharapkan oleh Konsumen. Metode yang digunakan dalam pengambilan keputusan dalam penelitian ini nanti bisa menjadi acuan bagi Masyarakat dalam memilih Air Minum Dalam Kemasan Galon yang handal dimana metode yang digunakan adalah Sistem Pendukung Keputusan ANP (Analytic Network Process) yaitu salah satu metode dikembangkan oleh Prof. Thomas Lorie Saaty dari Wharton Business School di awal tahun 1970, digunakan untuk mencari rangking atau urutan prioritas dari berbagai alternatif yang ada dan dianalisis guna menentukan prioritas air minum dalam kemasan galon yang nantinya akan dipergunakan oleh konsumen. Hasil penelitian kuesioner di dapatkan merk Air Minum Dalam Kemasan yang banyak di konsumsi oleh masyarakat di Kota Medan dalam penelitian ini adalah Aqua 40,08%, Ades 22,13, Prima 19,dan Cleo 18,89 % .
PERANCANGAN APLIKASI AUGMENTED REALITY PENGENALAN ALAT ROBOTIKA DASAR BERBASIS ANDROID
Authors: Azura Nurul , Saleh Alfa , Sari Ria Eka
Published: March 2022

Alat robotika adalah komponen dasar penyusun robot yang semakin berkembang baik dari segi bentuk ataupun fungsi karena adanya tuntutan dari kebutuhan masyarakat pada era teknologi ini. Permasalahan yang sering terjadi adalah  alat robotika sulit dipahami oleh masyarakat karena  tidak melihat bentuk tiga dimensi dan hanya melihat bentuk alat robotika melalui foto atau gambar yang mana foto atau gambar tersebut hanya berbentuk dua dimensi. Lalu saat membeli alat robotika sering terjadi kesalahan dikarenakan beberapa alat robotika memiliki persamaan antara satu alat dengan yang lainnya sehingga hal ini bisa menyebaban kerugian secara materi. Oleh karena itu, Penulis melakukan penelitian untuk merancang Aplikasi Augmented Reality Pengenalan Alat Robotika yang bertujuan untuk mengenalkan alat robotika secara tiga dimensi namun dalam bentuk maya atau tidak nyata yang dapat digunakan secara praktis melalui android. Dalam penelitian ini, Penulis menggunakan metode marker based tracking dimana jenis marker yang digunakan yaitu kertas dengan bacaan nama alat yang ingin diketahui
ANALISIS SENTIMENT DATA TWITTER MENGGUNAKAN ALGORITMA SUPPORT VECTOR MACHINE DAN NAIVE BAYES TERHADAP PEMBERITAAN PERKEMBANGAN PANDEMIK CORONA
Authors: Hakim Tanjung Dahri Yani , Lestari Silvia
Published: March 2022

Twitter merupakan salah satu media sosial yang sangat banyak digunakan untuk memberikan kritik akan sebuah pemberitaan atau masalah pribadi mereka.pada saat ini sedang banyak pembicaraan mengenai perkembangan virus corona di indonesia maupun di dunia, banyak media dunia yang memberikan pemberitaan melalui twitter dan ada pula para penggunaan yang memeberikan tanggapan terhadap pemberitaan tersebut. Maka dari itu pada penelitian ini dilakukannya analisis terhadap tweet atau tanggapan para pengguna twitter terhadap perkembangan atau isu pandemik korea. Penelitian ini dilkukan dengan cara memisahkan sentiment atau tanggapan yang negatif dan positf menggunakan algoritma naive bayes, dan Support Vector Machine ( SVM ). Hasil pengujian yang dilakukan dapat menunjukkan bahwa tingkat akurasi dengan term frequency memberikan hasil hasil akurasi yang lebih baik daripada akurasi dengan fitur TF-IDF. Metode Support Vector Machine menghasilkan akurasi yang lebih baik daripada metode Naive Bayes baik dalam klasifikasi sentimen maupun dalam klasifikasi kategori. Namun demikian, secara keseluruhan penggunaan metode Support Vector Machine dan Naive Bayes sama-sama memiliki performansi yang cukup baik untuk melakukan klasifikasi tweet.
Meningkatkan kompetensi pengelola bumdes pada manajemen bisnis dan manajemen keuangan bumdes “panca artha mandiri” pemerintah desa dangin puri kauh denpasar bali
Authors: Miko Andi Wardana , Lestari Denok , Semara I Made Trisna , Parwati Komang Shanty Muni , Wijaya Nyoman Surya
Published: March 2022

Tujuan Pengabdian Kepada Masyarakat (PKM) ini adalah meningkatkan profesionalitas pengelola BUMDes dalam pengelolaan bisnis dan keuangan BUMDes. Metode yang digunakan dalam kegiatan ini adalah metode pembelajaran partsipatif dalam bentuk ceramah, diskusi, Tanya jawab dan praktik terkait dengan pengelolaan keuangan BUMDes. Materi pelatihan yang diberikan mencakup pengelolaan industri dikomparasikan dengan perkembangan BUMDes dan regulasinya, sistem pengorganisasian BUMDes, Akuntansi BUMDes dan penatausahaan serta pertanggung jawaban keuangan BUMDes. Peserta workshop pengelolaan keuangan BUMDes ini terdiri atas kepala desa/wakil desa dan pengelola BUMDes “Panca Arta Mandiri” Desa Dangin Puri Kauh, Kecamatan Denpasar Utara, Kota Denpasar Provinsi Bali. Hasil yang dicapai dari program pengabdian kepada masyarakat (PKM) ini adalah meningkatnya pengetahuan dan ketrampilan aparatur pemerintah desa dan pengelola BUMDes dalam pengelolaan bisnis dan keuangan BUMDes.
Pandemi covid-19 terhadap operasional food and beverages service di sabeen restaurant the haven bali seminyak
Authors: Indrayani Ni Putu Githa
Published: March 2022

Kegiatan operasional merupakan kegiatan inti yang memfokuskan restoran khususnya di bidang food and beverages service bisa menghasilkan profit atau keuntungan. Penelitian ini dilaksanakan karena munculnya Pandemi COVID-19 yang memberikan pengaruh terhadap operasional food and beverages service di Sabeen Restaurant The Haven Bali Seminyak yakni penjualan menu, pendapatan, serta cost control. Dalam kaitannya dengan penelitian ini, penulis ingin mengetahui apa saja yang menjadi pengaruh dan upaya yang dilakukan pramusaji dalam menanggulanginya sehingga penelitian ini dapat menjadi solusi dalam pemecahan permasalahan yang sama. Penelitian ini menggunakan data primer dan data sekunder serta menggunakan teknik pengumpulan data observasi untuk mengetahui perbandingan kegiatan operasional sebelum pandemi dengan kegiatan operasional selama pandemi serta teknik pengumpulan data wawancara terhadap Assistant Restaurant Manager dan Assistant Bar Manager. Teknik analisis data yang digunakan adalah teknik analisis data deskriptif kualitatif dengan cara memaparkan perbandingan antara keseluruhan data yang didapat dengan kenyataan yang terjadi di Sabeen Restaurant The Haven Bali Seminyak. Hasil penelitian ini menunjukkan bahwa 11 dari 16 kegiatan yang berhubungan dengan operasional restoran menerima pengaruh dari Pandemi COVID-19. Segala upaya dalam menanggulangi pengaruh tersebut telah dilaksanakan, namun beberapa upaya masih menjadi kendala sehingga diperlukan evaluasi agar kegiatan operasional restoran selama Pandemi dapat diterapkan dengan maksimal.
Kinerja karyawan human resources department pada masa pandemi covid-19 di hotel u paasha seminyak
Authors: Pradnyani Ni Kadek Sintya Dwi
Published: March 2022

Kinerja merupakan peran yang sangat penting bagi suatu perusahaan. Kinerja memiliki peran yang penting lantaran bertujuan untuk memastikan karyawan bekerja secara efisien sepanjang pandemi Covid-19 dan mampu mengatasi masalah yang muncul. Karyawan harus kompeten pada tugas dan tanggung jawabnya secara optimal. Kinerja dapat dipengaruhi oleh faktor motivasi yang mendorong kinerja dari karyawan. Penelitian ini bertujuan yang pertama untuk mengetahui bagaimana kinerja karyawan Human Resources Department dimasa Covid-19 di Hotel U Paasha Seminyak dan yang kedua untuk mengatahui peran Human Resources Manager dalam memotivasi karyawan Human Resources Department. Metode yang digunakan metode kualitatif deskriptif dengan 1 orang informan dan 9 orang responden. Teknik pengumpulan data adalah wawancara, kuesioner, observasi, dan dokumentasi.Hasil penelitian menunjukkan bahwa kinerja karyawan Department Human Resources pada masa pandemi Covid-19 menunjukkan adanya penurunan kinerja setelah pandemi covid-19 muncul. Penurunan kinerja ini disebabkan oleh pengurangan gaji karyawan, perubahan jadwal kerja, dan pengurangan bonus dari karyawan. Motivasi kerja berkontribusi besar terhadap karyawan sehingga kinerja dari karyawan. Peran Human Resources Manager selaku pimpinan dari department ini memiliki peran yang sangat penting dalam memotivasi karyawan agar dapat membangun semangat dari karyawan. Human Resources Manager memberikan motivasi berupa penghargaan seperti promosi, bonus, dan program dari Hotel U Paasha yang bernama U Care of The Quarter yang terdiri dari U Care for Business, U Care for Guest, U Care for Employee, dan U Care of The Year.
Strategi pemasaran pada masa pandemi covid-19 di hotel amaris teuku umar
Authors: Christiawan Ericko Mahendra
Published: March 2022

Bali sendiri merupakan salah satu tujuan wisata yang sangat diminati oleh para wisatawan baik wisatawan mancanegara maupun wisatawan domestik yang saat ini mengalami pukulan sangat berat dari Pandemi Covid-19. Sektor pariwisata menjadi salah satu sektor di Bali yang paling terpukul karena Pandemi Covid-19. Tujuan dari penelitian ini adalah untuk menganalisis lingkungan internal serta lingkungan eksternal dengan menggunakan analisis SWOT di Hotel Amaris Teuku Umar dan untuk mengetahui alternatif strategi bagi Hotel Amaris Teuku Umar. Penelitian ini mempergunakan dua jenis data, yaitu data kualitatif dan kuantitatif. Data sekunder diperoleh dari website dan Sosial Media Hotel Amaris Teuku Umar. Data primer diperoleh data yang bersumber dari hasil wawancara mengenai mengenai indikator-indikator permasalahan yang sudah dirumuskan dalam penelitian ini, mengenai variabel STP (Segmentation, Targeting & Positioning), persepsi bauran pemasaran, serta pemberian bobot dan rating untuk perhitungan IFAS dan EFAS. Teknik analisis data yang dipergunakan adalah deskriptif kualitatif, analisis SWOT, IFAS, EFAS, kuadran dan matriks SWOT. Berdasarkan hasil dari analisis SWOT, Hasil dari analisis IFAS dan EFAS didapat titik koordinat sumbu X (internal) berada pada -0,60 dengan sumbu Y (external) -1,48 yang berada pada kuadran II (Diversifikasi), bahwa Hotel Amaris Teuku Umar menghadapi beberapa ancaman perusahaan, maupun strategi pemasaran namun Hotel Amaris Teuku Umar masih memiliki kekuatan dari segi internal. jadi Strategi yang harus diterapkan saat kondisi ini adalah dengan memanfaatkan kekuatan untuk memanfaatkan peluang jangka panjang.