bluuebunny/crossref_metadata_2025 huggingface dataset:
SIMULTANEOUS QUANTIFICATION OF TAMOXIFEN AND 4-HYDROXY-N-DESMETHYLTAMOXIFEN LEVELS IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY: DEVELOPMENT AND APPLICATION IN BREAST CANCER PATIENTS
Authors: Harahap Yahdiana , Leony Nathania , Silalahi Letare Merry Chresia , Andalusia Rizka
Published: December 2018

Objective: This study was aimed to develop a highly sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodfor the simultaneous quantification of tamoxifen, endoxifen, and clomiphene (internal standard) levels in human plasma.Methods: Plasma samples from 40 patients with breast cancer were prepared through liquid–liquid extraction in ethyl acetate, and chromatographicseparation was performed on an Acquity UPLC BEH C18 column (1.7 μm, 2.1 mm×100 mm). The sample was eluted within 6.50 min at a flow rate of0.200 ml/min under a gradient of 0.2% formic acid and acetonitrile. The analytes were then quantified through triple quadrupole MS with electrosprayionization in the positive ion mode and multiple reaction monitoring.Results: The method was successfully used to quantify the plasma levels of tamoxifen and endoxifen, yielding respective measurement rangesof 42.19–249.23 ng/ml and 1.52–26.62 ng/ml. Overall, this detection method was sensitive, with lower limits of quantitation of 0.625 ng/ml fortamoxifen and 0.125 ng/ml for endoxifen. In addition, this method was precise and accurate, with a between-run variation range of 5.19–12.38% and%diff range of −10.82%–+13.10%.Conclusion: This method demonstrated that approximately 80% of patients had plasma levels of endoxifen exceeding the expected clinical threshold(5.9 ng/ml). This rapid and simple method could be used to monitor tamoxifen metabolism and adjust doses as needed to achieve maximumeffectiveness.
STRATEGY TO MASK THE BITTER TASTE OF MOMORDICA CHARANTIA EXTRACT USING ALGINATE–GELATIN BEADS
Authors: . Sutriyo , Iswandana Raditya , Fauzi Fauzana
Published: December 2018

Objective: This study is aimed to develop a strategy to mask the bitter taste of Momordica charantia Linn. extract using alginate–gelatin beads.Methods: Beads of bitter melon fruit extract (M. charantia Linn) were prepared using an ionic gelation method in which cross-linking occurs betweensodium alginate and calcium chloride that serves to mask the bitter taste. Beads were prepared using sodium alginate (1.5% w/v) with variousconcentrations of bitter melon fruit extract (1:2, 1:1, and 1:0.5), gelatin (2% w/v), and CaCl2 3%. The obtained beads were then characterized bothphysically and functionally, and their morphology, process efficiency, particle distribution, swelling index, and water content were recorded.Results: Formula 1 beads, with a 1:2 ratio of extract: alginate, displayed a near-round shape with a diameter of 600–1 200 μm, a swelling index of113.21%, and a moisture content of 15.34%. In addition, these beads were able to significantly cover the bitter taste (p<0.05).Conclusion: Formula 1 beads with a 1:2 ratio of extract: alginate can effectively mask the bitter taste of M. charantia Linn.
SYNTHESIS AND ANALYSIS OF ZINC METHIONINE, ZINC GLYCINE, COPPER LEUCINE, AND COPPER GLYCINE COMPLEXES USING ATOMIC ABSORPTION SPECTROPHOTOMETRY
Authors: Nastiti Sekar Alinda , . Harmita , Jatmika Catur
Published: December 2018

Objective: The aim of this study was to perform metal-amino acid synthesis and to analyze the free and bonded mineral concentrations.Methods: In this study, the synthesis of amino acid metal complexes was carried out by reacting free metal ions, derived from a water-soluble metalsalt, with amino acids in a 1:2 molar ratio.Results: The respective yields of this synthesis process were 95.38%, 95.95%, 76.31%, and 93.91% for zinc (Zn)-methionine (Zn(Met)2), Zn-glycine(Zn(gli)2), copper-leucine (Cu(leu)2), and Cu-glycine (Cu(gli)2) complexes, respectively. The metal-amino acid complexes were then separated usingcolumn chromatography and further analyzed by atomic absorption spectrophotometry (AAS). The bonded metal concentrations of the Zn(Met)2,Zn(gli)2, Cu(leu)2, and Cu(gli)2 complexes were 189.32 mg/g, 353.78 mg/g, 180.89 mg/g, and 275.11 mg/g, respectively. The free metal concentrationsof the Zn(Met)2, Zn(gli)2, Cu(leu)2, and Cu(gli)2 complexes were 13.57 mg/g, 12.92 mg/g, 0.19 mg/g, and 2.12 mg/g, respectively.Conclusion: In this study, Zn(Met)2, Zn(gli)2, Cu(leu)2, and Cu(gli)2 complexes were successfully formed and analyzed. The mineral concentration ineach complex differed depending on the type of mineral and ligand.
Effect of a Medical Student-Led Curriculum on Teen Health Knowledge and Intentions: An Evaluation of the MiHealth Pilot Program
Authors: Brown Kathryn S. , Meixner Kaitlin A. , DeBenedictus Christina M. , Riley Margaret A.
Published: December 2018

Introduction: Adolescents are often thought of as a healthy population, however, they routinely engage in high-risk behaviors that can lead to health problems. Medical students designed MiHealth, a program in which medical students teach health lessons in the high school classroom to help address these behaviors.
Methods: A series of six lessons were created and implemented in the classroom for this pilot study focused on sexual health, intimate partner violence, mental health, smoking and marijuana, nutrition, and physical fitness. High school students in grades nine through twelve at a public high school in southeast Michigan receiving the MiHealth curriculum (N=52) or the standard health education curriculum (N=61) were surveyed on health knowledge, attitudes, and intentions before and after the program.
Results: Six weeks after program completion, high school students who received the MiHealth curriculum scored significantly higher on health knowledge (P=0.007), and expressed significantly healthier attitudes and intentions toward risk behavior compared to controls (P=0.025). Among individual themes, MiHealth resulted in significant knowledge gains in sexual health (P=0.001) and mental health (P<0.025), and significantly healthier attitudes regarding sexual health (P=0.047), nutrition (P=0.040), and smoking and marijuana (P=0.012).
Conclusions: MiHealth demonstrated promising improvements in health knowledge retention and attitude changes in adolescents 6 weeks after program completion. An interactive curriculum targeting key adolescent health topics given by near-peer medical student educators may provide benefits beyond traditional high school health curricula.
Significance of hysteroscopy in diagnosis and treatment of congenital uterine anomalies
Authors: Saranovic Milena , Matejic Suzana , Matejic Nebojsa , Radic Ivan , Trajkovic Goran
Published: December 2018

Background/Aim. Hysteroscopy is one of the important methods in the endoscopic diagnosis and treatment of infertility, particularly at the examination of the morphology and function of the uterus. Uterine factor is present at 10% of infertile women, in which changes of the uterus can be congenital or acquired. The aim of this study was to estimate the significance of hysteroscopy in the diagnosis and treatment of congenital anomalies of the uterine cavity in patients in whom there was a reasonable suspicion for them based on prior clinical, ultrasound and hysterosalpingography (HSG) findings. The significance of hysteroscopy is considered in relation to the number of pregnancies achieved depending on the malformations in the 12 months period after the completion of the diagnostic or operational hysteroscopy. Methods. The study included 176 patients with congenital uterine anomalies, which had undergone hysteroscopy, diagnostic or operative, in the period from January 1, 2013 till January 1, 2016. Percentage of pregnancy was followed at all patients during the first 12 months after surgery. Patients were divided into two groups: the first group contained women who had pregnancy, and the second group included women who earlier were not pregnant. Their characteristics were compared, such as: age, duration of infertility, previous pregnancy and/or pregnancy loss, HSG and ultrasound findings, types of congenital anomalies, type of hysteroscopy, as well as the existence of associated pathology. Results. The mean age of patients tested in the study was 35 years. The group of patients with primary infertility had a total of 107 patients, while 69 patients were with secondary infertility. The average duration of infertility was 3 years in the studied patients. In the 12-months period, 39 of the examined women began pregnancy, which was completed with term delivery in 33 women. ?2 test showed a statistical significance difference (p < 0.05) between the groups of the patients with or without pregnancy after hysteroscopy in relation to infertility types as well as in relation to the number of previous miscarriages. Conclusion. Subseptus and septus uteri were the most common congenital uterine malformations in our patients. Very rare were uterus arquatus, uterus unicornis and uterus bicornis. In our study, 1/5 of examined women achieved pregnancy after hysteroscopy in the reporting period of 12 months, while the majority of these pregnancies ended with term delivery. The percentage of miscarriages in the examined women was reduced from 38% to 15% after hysteroscopy. In women who achieved pregnancy, uterine septum and subseptum were mostly diagnosed and in these patients hysteroscopic resection was successfully performed.
The effect of moral foundations and personality dimensions of health workers on patient satisfaction with healthcare services
Authors: Terzic Neda , Pecujlija Mladen , Cvetkovic Sreten , Lukic-Sarkanovic Mirka
Published: December 2018

Background/Aim. Working with people in medical practice requires knowledge of the basic principles of personality psychology. The aim of this research was to examine the influence of moral foundations and personality dimensions of health workers on patient satisfaction with health service, as well as determining the factors influencing their satisfaction. Methods. The research was conducted using the Big Five Inventory (BFI), the Moral Foundations Questionnaire (MFQ) and the Questionnaire of patient satisfaction with healthcare service, from October 2014 to March 2016. The survey involved 693 respondents: 329 healthcare workers (44 males and 285 females) and 364 patients (154 males and 210 females). Results. With the increase of the openness of healthcare professionals, the patients' satisfaction was also growing. Regarding moral foundations of healthcare workers, there was an opposite trend ? with lower authoritativeness of healthcare workers, patient satisfaction was greater. Finally, with more pronounced purity of healthcare workers there was a decrease in the level of patients? satisfaction with the received healthcare service. Conclusion. There is a direct association between the moral foundations and personality dimensions of health workers, and patients? satisfaction with healthcare service. Thus, any strategy for improving the quality of healthcare service should take into account personal characteristics of healthcare workers. Healthcare professionals are expected to fulfill their life and professional tasks in as a human way as possible, since preservation of the health and helping to overcome an illness, in case it develops, are the basic values of every human being. It should result in more clearly defined priorities for improvement of the quality of work of healthcare workers.
Significance of the pulsatility index in the evaluation of hemodynamic changes in peripheral arterial circulation in the obese treated with orlistat
Authors: Hajdukovic Zoran , Dragovic Tamara , Radjen Slavica , Marinkovic Dejan , Ratkovic Nenad , Kikovic Sasa
Published: December 2018

Background/Aim. Prolonged hyperinsulinemia accelerates the process of endothelial dysfunction and arteriosclerotic changes affecting the development of cardiovascular and cerebrovascular diseases. There are various measuring techniques for the evaluation of early functional changes in the arterial wall such as: flow-mediated endothelium-dependent vasodilation, impulse wave analysis, intima-media thickness assessment, venous plethysmography and so on; however, each has certain limitations in results interpretation. The aim of this study was to indicate the association of the pulsatility index (PI) that shows peripheral arterial contractility, with the changes in metabolic parameters under insulin resistance conditions. Methods. The study included a total of 30 healthy obese subjects with the values of body mass index more than 30 kg/m2, randomized with double blind design into two groups: placebo and orlistat. The extent of insulin sensitivity was calculated on the basis of glycemia and insulinemia values using an appropriate formula. Results. The obtained results suggest a statistically significant improvement in the PI index in the orlistat group (p < 0.002), while there was no such improvement in the placebo group. Conclusion. The results obtained in this study indicate the improvement in insulin sensitivity within early arteriosclerosis is a significantly favorable effect of orlistat on peripheral arterial circulation additionally supported by the reduction in levels of lipid fractions, especially triglycerides. Early hemodynamic changes under conditions of the reduced insulin resistance are characterized by the increase in arterial wall contractility evaluated by the PI determination.
Teledentistry in dental care of children
Authors: Popovic Lidija , Odalovic Dragica , Zivkovic Dusan , Miladinovic Milan , Lazic Zoran , Duka Milos , Zivkovic Milan
Published: December 2018

nema
Factores motivacionales para la investigación y los objetos virtuales de aprendizaje en estudiantes de maestría en Ciencias de la Educación / Motivational factors to research and Virtual Learning Objects in Maesters students in Education Sciences
Authors: Veytia Bucheli María Guadalupe , Contreras Cipriano Yessica
Published: December 2018

El empleo de las tecnologías de la información y la comunicación se ha incrementado en diversos ámbitos, especialmente en el educativo, donde cada vez es más frecuente que se usen objetos virtuales de aprendizaje (OVA) para abordar diversos temas, lo que motiva a los estudiantes a trabajar tanto de manera individual como de forma colaborativa. Por ello, el objetivo de la presente investigación fue identificar los factores motivacionales de un grupo de estudiantes de la maestría en Ciencias de la Educación de una institución pública del estado de Hidalgo (México) en torno al trabajo con los OVA en el proceso de aprendizaje de la investigación. Para ello, se realizó una entrevista colectiva con 22 estudiantes (3 hombres y 19 mujeres) de la maestría en Ciencias de la Educación de una universidad pública del estado de Hidalgo (México). Los resultados demuestran, con base en la teoría de las expectativas de Vroom (1964), que la motivación de los sujetos de estudio disminuye cuando no saben cuál tema pudieran elegir para desarrollar en sus proyectos de investigación y cuando no pueden apoyarse en los TIC para facilitar esa tarea, pues la mayoría aún necesita consolidar sus habilidades para saber con claridad qué, cómo y dónde seleccionar la información que requieren sus respectivos temas de estudio. Para atender esta situación, se deben crear estrategias eficaces, eficientes y pertinentes que se centren en las variables que dificultan en estos participantes el uso de las herramientas tecnológicas, como buscadores, plataformas virtuales, bancos de datos, revistas de investigación, entre otros.
Glauco Mattoso e as “memórias de um pueteiro”: identidade literária como estética de si
Authors: Caixeta Ana Paula Aparecida
Published: December 2018

O livro Memórias de um pueteiro – As melhores gozações de Glauco Mattoso (1982) aponta uma revisitação ao conhecido Jornal Dobrabil (1981), destacando-se pela escolha do autor por fragmentos textuais já publicados, formando parte de um projeto estético que, acredita-se, compõe o reforço identitário da persona Glauco Mattoso. Pode-se entender que esse jogo literário que fomenta a figura pública do escritor cego (glaucomatoso) preocupa-se com as instâncias da criação, da narrativa e da recepção enquanto processo criativo, corroborando para uma consciência estética acerca de si e do outro – no caso, seus heterônimos. Observado isso, o objetivo norteador deste artigo é apresentar essa publicação ao leitor e trazer à tona a opção do autor por discursos ficcionais que corroboram com suas características de escritor fescenino e escatológico, conforme a construção da sua identidade literária.
Apontamentos sobre a presença das classes populares na literatura brasileira: representação, autorrepresentação e propostas para uma historiografia
Authors: Da Silva Julio Cezar Bastoni
Published: December 2018

O artigo apresenta algumas reflexões de uma pesquisa em curso sobre a questão da presença das classes populares na literatura brasileira, e se centra, nesse trabalho, na dualidade entre representação e autorrepresentação. Nesse sentido, tratam-se de alguns apontamentos que visam oferecer propostas para mirar a questão em forma historiográfica, oferecendo possibilidades de análise de autores da tradição literária brasileira que, não obstante, podem servir como formas de entrada e diálogo com os debates contemporâneos acerca do tema, tal como se percebe a partir das obras de Euclides da Cunha, Clarice Lispector e Lima Barreto.
Alteridade e História: escritura e narrativa como uma ética do Outro
Authors: Torrão Filho Amilcar , Schneider Alberto Luiz
Published: December 2018

Neste artigo procuramos compreender como o conceito de alteridade é central para pensar os procedimentos da História, ainda que ainda não tenha se constituído como um conceito vigente na teoria da História. A partir da noção de alteridade de Emmanuel Lévinas e Judith Butler, pensamos como Michel de Certeau e Paul Ricoeur tratam a escritura da história e seus procedimentos narrativos como uma tomada de posição ética em relação ao Outro, o nosso passado.
O fim do homem soviético, de Svetlana Aleksiévitch: considerações sobre a literatura, o testemunho e a memória
Authors: Garlet Deivis Jhones , Zamberlan Lucas Da Cunha
Published: December 2018

Svetlana Aleksiévitch tem se destacado, mundialmente, pela composição de obras que se distanciam dos paradigmas tradicionais de representação literária por meio do recurso expressivo de exposição de vozes que pleiteiam a condição de testemunhas de um evento traumático. De fato, é pela revelação de vários relatos pessoais, em uma oralidade intensa, que as testemunhas se convertem em personagens e narradoras de um mosaico polifônico, no qual cada fragmento representa uma voz que tenta não ser esquecida, conferindo o tom memorialista às narrativas. Diante disso, propomos uma análise de O fim do homem soviético em termos formais e de conteúdo, sobremodo a partir de teóricos como Bakhtin e Benjamin, de maneira a nos aproximarmos das posições axiológicas contidas na obra. A partir dos resultados obtidos, avaliamos que as estratégias literárias empreendidas pela autora potencializam a complexidade histórica relativa ao desmembramento da União Soviética, alargando, pelos caminhos do testemunho e da memória, os limites da própria literatura.
Alteridade
Authors: Casali Alipio Márcio Dias
Published: December 2018

RESUMO O presente texto se propõe a articular algumas das principais referências teóricas sobre o tema da Alteridade, com apoio no conceito de Exterioridade de Emanuel Lévinas. Num primeiro movimento são recolhidos alguns dos principais registros históricos de tradições e sistemas político-culturais do Ocidente que impliquem a relação de Alteridade. Nesse percurso, busca-se explicitar a presença das matrizes do humanismo helênico (o Outro como o visto) e humanismo semita o (o Outro como o ouvido). Em seguida o tema da Alteridade é confrontado com o da Identidade, dada a inerente reciprocidade de ambos. No movimento seguinte, trata-se de submeter a premissa de transcendentalidade da Alteridade às determinações biológicas do modo de funcionamento do cérebro, que a processa como reações químicas e eletromagnéticas. O texto conclui com algumas referências acerca da Exterioridade do Outro no cotidiano, em suas posições na política, na erótica, na pedagógica e na amizade.
Viittomakielet hybridisysteemeinä - hämärärajaisuus ja epäkonventionaalisuus osana viittomakielten rakennetta
Authors: Jantunen Tommi
Published: December 2018

Tässä artikkelissa tarkastellaan hämärärajaisuutta ja epäkonventionaalisuutta osana joitakin kaikista viittomakielistä löydettyjä yksiköitä ja rakenteita ja niiden käyttöä. Täsmällisemmin artikkelin fokuksessa ovat tietyt muodoltaan ja merkitykseltään tilanteisesti muuntuvat viittomat (erityisesti niin kutsutut osittain leksikaaliset viittomat) sekä eräänlainen vaihteleva-asteinen näytteleminen (niin kutsuttu konstruoitu toiminta), jota viittojat käyttävät tuottamiensa syntaktisten rakenteiden osana ja niiden sijaan. Käytännössä artikkeli esittelee näkemyksen, jonka mukaan molemmissa tarkastelun kohteena olevissa ilmiöissä on kyse samasta asiasta eli kielen diskreettien ja konventionaalisten ominaisuuksien sekoittumisesta hybridiluonteisesti kieleenkuuluvien hämärärajaisten ja epäkonventionaalisten ominaisuuksien kanssa. Artikkeli pohtii lyhyesti myös puhuttujen kielten luonnetta hybridisysteemeinä.
Kielikäsitykset vanhustyössä - asukkaiden, hoitajien ja esimiesten käsityksiä hyvästä vuorovaikutuksesta ja kielenkäytöstä
Authors: Mäntynen Anne , Tapionkaski Sanna , Pietikäinen Sari
Published: December 2018

Artikkelissa tarkastellaan käsityksiä hyvästä vuorovaikutuksesta ja kielenkäytöstä vanhainkodissa kriittistä diskurssintutkimusta ja etnografiaa hyödyntäen. Tutkimus perustuu aineistoon, joka kerättiin haastattelemalla ja havainnoimalla asukkaita, hoitajia ja esimiehiä kahdessa monikielisessä vanhusten hoitoyksikössä. Aineistosta analysoitiin vanhustyön kieleen liittyviä kieli-ideologioita ja metakieltä. Analyysin tuloksena nousi esiin neljä keskeistä vanhuslähtöisen kielen ulottuvuutta: (1) vuorovaikutuksen laatu, määrä ja sävy, (2) puhuttelun ja nimeämisen tavat, (3) äidinkieli ja monikielisyys sekä (4) kosketuksen ja muun multimodaalisen vuorovaikutuksen merkitys. Tulokset tuovat esiin, että vanhainkoti on institutionaalinen paikka, joka on asukkaille koti ja hoitajille ja esimiehille työpaikka. Nämä toisistaan poikkeavat positiot luovat erilaisia tarpeita ja toiveita vuorovaikutukselle ja kielenkäytölle: siinä missä hoitajat pyrkivät tekemään työnsä tarkoituksenmukaisesti ja sujuvoittamaan hoitoarkea, asukkaat kaipasivat keskustelua, rupattelua ja yhteistä toimintaa hoivakodin arkeen. Hoitajien kielikäsityksissä korostuvat puheen ymmärrettävyys ja selkeys, asukkailla kielen sosiaalinen merkitys, keskustelu ja kuunteleminen. Tulokset kertovat myös siitä, että vanhusten keskinäinen tuettu vuorovaikutus ja musiikin aktivoiva käyttö voisivat olla keinoja lisätä vanhuksia osallistavaa vuorovaikutusta vanhainkodissa.
Estructura de departamento de ingeniería y mantenimiento, para instituciones hospitalarias de III nivel en Colombia
Authors: Andrade Mauricio Ernesto , Camacho Cogollo Javier Enrique
Published: December 2018

El tema central de este trabajo se focaliza en la postulación de la estructura de un DIM (departamento de ingeniería y mantenimiento) para clínicas y hospitales de tercer nivel en el territorio colombianoPara tal propósito, se efectúo una vigilancia tecnológica, entrevistas, encuestas, estudios, entre otras estrategias; que permitieron consolidar un modelo robusto de departamento ingenieril, que conjuga a su vez todas las buenas prácticas y características de éxito que han permitido tanto el ámbito local como internacional hacer que las instituciones hospitalarias crezcan desde el punto de vista económico, de eficiencia en prestación de servicios, disminución de riesgo asociado a dispositivos médicos y aumento de índices de calidad.Posteriormente, se analizan las interrelaciones del departamento de ingeniería y mantenimiento con otras secciones del hospital; específicamente con los departamentos de comercial, informática y activos fijos. Finalmente se postularon los indicadores para la gestión de tecnología en salud que contribuyen al fortalecimiento de la estructura del departamento de ingeniería y mantenimiento.
Hygienic characteristics of the chemical composition of groundwater in Ryazan region
Authors: Solovyev DA , Dementiev AA , Kluchnikova NM , Prokhorov NI
Published: December 2018

Among the factors that have a strong impact on public health the environment, living conditions, food and water quality are just as important as socio-economic forces. Providing the population with access to safe potable water has become a socio-economic priority in Russia. The aim of this work was to characterize the aquifers supplying the population of Ryazan region with water for personal and domestic needs and to compare their chemical composition. Sample collection was performed in cooperation with the Center for Hygiene and Epidemiology (Ryazan region). The obtained data were processed using ANOVA. The Kashirsky and Ozersko-Khovansky aquifers turn to be the most commonly used ones supplying water to 30.7% and 27.3% of the total artesian wells. The Oksko-Tarussky and Podolsko-Myachkovsky aquifers rank second, feeding 21% and 18.9% of the wells, respectively. The share of the Kasimovsky aquifer in the total water supply is only 2.1%. Although the recommended lifespan of an artesian well is 25 years, two-thirds of the wells in Ryazan region have been in service for 26 to 50 years, and one in every 4 wells is over 50 years old. The chemical composition of the groundwater drawn from different aquifers is different. High concentrations (0.7 mg/l) of iron (Fe2+) are present in the water from the Ozersko-Khovansky aquifer (р ≥ 0.05). Sulfates are found in abundance in the Podolsko-Myachkovsky and Ozersko-Khovansky aquifer. The water from the Oksko-Tarussky aquifer contains high concentrations of ionized ammonia.
Evaluation of the rivaroxaban-influenced effect of ABCB1 and CYP3A5 gene polymorphisms on prothrombin time in patients after total hip or knee replacement surgery
Authors: Sychev DA , Minnigulov RM , Ryzhikova KA , Yudina IYu , Lychagin AV , Morozova TE
Published: December 2018

Rivaroxaban is a safer and more effective alternative to warfarin. However, there are reports of some cases of major hemorrhagic complications associated with rivaroxaban that significantly impair the patients' quality of life and can lead to a fatality. Personalized therapy, including pharmacogenetic testing, may help prevent such adverse events. This study aimed to investigate how ABCB1 3435C>T (rs1045642) and CYP3A5 6986A>G (rs776746) gene polymorphisms, when carried by a patient taking rivaroxaban to prevent thrombosis after total hip or knee replacement surgery, affect prothrombin time (PT). Sixty-five patients participated in the study. Their genotypes were identified by PCR in real time. To learn PT peculiar to each patient, we collected venous blood on the 5th day of their anticoagulation therapy, 1 hour before they took rivaroxaban and 3 hours after. Having calculated %ΔPT, we divided the patients into 2 groups: 1) %ΔPT ≤ 0 (n = 7; 10.8%); 2) %ΔPT > 0 (n = 58; 89.2%). Regarding the distribution of rs1045642 polymorphism, we determined the difference between the groups to be statistically significant (χ2 = 6.64; p = 0.027). As for rs776746 polymorphism, the difference was insignificant (χ2 = 0.101; p = 1.0). We discovered that rs1045642 polymorphism has a significant effect on PT variance in patients taking rivaroxaban to prevent thrombosis after total hip or knee replacement surgery.
Synthesis of Au (III) polyacrylates and study of their tumoricidal activity
Authors: Shibaeva AV , Pozdniakova NV , Spiridonov VV , Smirnova MS , Korman DB , Ostrovskaya LA , Abzaeva KA , Belyakova AV , Biryukova YuK , Zylkova MV , Ivanov KP , Shevelev AB , Kuzmin VA
Published: December 2018

Aurumacryl is an incomplete metal salt of poly(acrylic acid) that exhibits hemostatic activity and inhibits the growth of transplantable carcinomas in vivo. The samples of aurumacryl synthesized following the original technique are insufficiently soluble, which complicates the study of the mechanisms involved in their synthesis and underlying their cytotoxic effect. The aim of this work was to study the impact of the following factors on aurumacryl properties: the molecular weight of the polyacrylate polymer in a range between 2 and 1,000 kDa, the presence of a counterion H+ or Na+, the molar ratio of AuCl– to the polyacrylate polymer (1 : 5 and 1 : 10), the total concentration of the polyacrylate polymer during synthesis (0.1 and 3%), and the type of drying (lyophilization). By comparing the cytotoxicity of aurumacryl samples with significantly different molar ratio of gold ions to the polyacrylate polymer against human breast carcinoma cells (MCF-7), we established that the proportion of the polymer and its molecular weight in the sample do not affect the biological properties of the synthesized substance. Using UV spectroscopy, we revealed that the concentration of Au (III) ions in aurumacryl determines its cytotoxicity.
Evaluasi Implementasi Standar Akuntansi Pemerintahan Berbasis Akrual pada Pemerintahan Provinsi Sumatera Utara
Authors: Hasibuan Raya Puspita Sari
Published: December 2018

The aim of this research is to examine the evaluation of implementation government standard accounting accrual based. The sampling method of this research used census sampling, whether the sample of this research is 415 respondends. Samples of the research is Local Government Unit (SKPD) in the five district or city in North Sumatera, they are Langkat, Binjai, Medan, Samosir and Humbang Hasudutan. This research using SmartPLS application to analyse the data. The main problems is about how difficult government coordinate the human resource in the district or city government especially in implementation of accounting system. Methods of data analysis used in this research is testing the quality of the data, outer model and inner model test. Outer model consists of convergent validity, discriminant validity and reliability test and inner model consists of adjusted R square and Predictive Relevance (Q2). The result of this research is partially human resource, software and hardware and understanding of government standard accounting accrual based have effect to implementation government standard accounting accrual based.
Efectividad de los programas de intervención motriz en el desempeño de los patrones básicos de movimiento: un meta-análisis
Authors: Chaves-Castro Karla , Jiménez-Díaz Judith , Salazar-Rojas Walter
Published: December 2018

El objetivo del presente estudio fue examinar la efectividad de los programas de intervención motriz en el desempeño de los patrones básicos de movimiento y analizar posibles variables moderadoras. Para ello, se han considerado programas de intervención motriz publicados hasta el año 2015. La búsqueda de los estudios se realizó en catorce bases de datos, revisando referencias y consultado a expertos del área. La selección de los estudios y la extracción de los datos la llevaron a cabo dos de los autores de forma independiente. La calidad de los estudios se evaluó por medio de la escala TESTEX (puntaje máximo = 10 puntos). Bajo el modelo de efectos aleatorios se calculó del tamaño de efecto (TE) de la diferencia de medias estandarizada. Se examinó la heterogeneidad utilizando la Q estadística y la consistencia utilizando I2. De 72 estudios revisados, se han incluido finalmente 32, que representan un total de 2607 niños y niñas con edades entre 4 y 17.5. La calidad de los estudios presenta una M±DE = 6.35 ±0.93. Los resultados indican que, según los estudios, los niños y niñas que habían participado en programas de intervención motriz mejoraron significativamente entre el pretest y el postest (TE= 0.972 p = 0.01 IC95%= 0.84 a1.09; Q= 1467, I2= 88,7%); por el contrario, los que no habían participado de alguna intervención no mostraban mejora significa (TE= 0,072, p = 0,63 IC95%= -0.13 a 0.27, Q= 18.1, I2= 55.9%). Se analizaron posibles variables moderadoras. En fin, el TE global sugiere que participar en intervenciones motrices produce una mejoría en el desempeño de los PBM.
Kemajuan perawatan ortodontik dengan sekrup ekspansi rahang atas pada crowding ringan

Orthodontic treatment progress of mild crowding with maxillary expansion screws

Authors: Vania Ester , Zenab Yuliawati , Sunaryo Iwa Rahmat
Published: December 2018

Pendahuluan: Perbaikan susunan gigi geligi dan oklusi dapat dilakukan dengan perawatan ortodonti. sifat kooperatif pasien sangat berpengaruh dalam kemajuan perawatan dan memerlukan waktu yang panjang. Tujuan penelitian adalah mengetahui kemajuan perawatan pasien dengan sekrup ekspansi rahang atas pada alat ortodonti lepasan di Rumah Sakit Gigi dan Mulut Fakultas Kedokteran Gigi Universitas Padjadjaran. Metode: Jenis penelitian yang digunakan adalah deskriptif. Teknik pengambilan sampel dilakukan secara purposive sampling dengan kriteria yang ditentukan, sebanyak 20 model studi crowding ringan yang dirawat menggunakan sekrup ekspansi rahang atas pada alat ortodonti lepasan. Hasil: kemajuan perawatan dengan mengaktivasi sekrup ekspansi secara rutin menunjukan terdapat pertambahan lebar lengkung gigi (LLG) serta jarak gigi 14-24 sebesar 49,1% (bermakna) dan 16-26 sebesar 33,8% (bermakna). Simpulan: Kemajuan perawatan dapat terjadi setelah aktivasi sekrup ekspansi sejumlah 9-10 kali, dimana jumlah aktivasi dan interval hari sebesar 49,1% dan 33,8% sehingga diperoleh ruang untuk memperbaiki susunan gigi pada pasien dengan crowding ringan.Kata kunci: sekrup ekspansi rahang atas, crowding ringan. ABSTRACTIntroduction: Improvement of the tooth and occlusion arrangement can be performed with orthodontic treatment. Cooperativeness of patients will be very influential in the treatment progress which requires a long time. The study was aimed to determine the development of a treatment with maxillary expansion screws on removable orthodontic appliances at Dental Hospital of Faculty of Dentistry Universitas Padjadjaran. Methods: The research was descriptive. The sampling technique was purposive sampling with the specified criteria, as much as 20 study models of mild crowding were treated using maxillary expansion screws in the removable orthodontic appliance. Results: The treatment progress by activating expansion screws continuously showed that there was an increase in the dental arch width and a distance of tooth number 14 – 24 was 49.1% (significant), and a distance of tooth number 16 – 26 of 33.8% (significant). Conclusion: Treatment progress can occurred after activation of expansion screws 9-10 times, where the number of activations and interval days was 49.1% and 33.8% so that space was obtained to improve the tooth arrangement in patients with mild crowding.Keywords: Maxillary expansion screw, mild crowding.
Latin American armed humanitarianism in Haiti and beyond
Authors: Hirst Monica
Published: December 2018

MINUSTAH represents a benchmark in the link between global securitization and humanitarian practices in Latin America and the Caribbean. Regional military responsibilities in Haiti turned useful to improve and expand capabilities employed in international humanitarian crisis.  Engagement in natural disaster has been the dominating terrain in which military humanitarian action takes place in Latin America and the Caribbean. Military presence in Haiti has also contributed for experimentation in the fight against organized crime and gangs, a growing concern on the radar of international humanitarian organizations and actors. Armed humanitarianism in the region has benefitted from ties with the US, particularly the South Command, and with the UN System, particularly the DPKO. Domestic and international involvement in humanitarian assistance has become major topic in regional intra-military initiatives, stimulated by exchange of new expertise and the expansion of teamwork programs. Simultaneously, armed humanitarianism has amplified the spectrum of civil-military relations by broadening interaction with local population and organizations in different parts of Latin America and the Caribbean. Yet, armed humanitarian is controversial in the region in face of its implication for human rights protection and the strength of democratic institutions. This text intends to trace a middle ground around military and humanitarian studies conceptualization by interlacing the concepts of postmodern military and armed humanitarianism. It parts from the assumption that both concepts, while focusing on different objects, may knit well to explain post-MINUSTAH Latin American military developments.
ANALISIS PRODUKTIVITAS PENGELOLAAN ZAKAT DARI SISTEM BAGI HASIL (Studi Kritis Bank Muamalat Cabang Kota Jayapura)
Authors: Siswanto Eko
Published: December 2018

Kedudukan zakat dalam Islam sangatlah penting dalam rangka menjaga eksistensi Islam dan umat. Begitu seriusnya kedudukan zakat ini, sehingga pada awal kekhalifahan Abu Bakar Ash-Shiddiq yang terdapat orang-orang yang melakukan pembangkangan untuk menunaikan zakat, oleh sebab itu khalifah melakukan ijtihad dengan memerangi mereka. Ini menunjukkan terhadap komitmen Islam dalam menanggulangi kaum dluafa secara berkelanjutan dan sistematis. Untuk mengakomodir jumlah kaum dluafa yang jumlahnya sangat banyak, pada saat sekarang ini para amilin menempuh upaya dengan menyalurkan zakat dalam bentuk produktif. Sebenarnya, apabila dikaji lebih jauh, sejak dahulu pemanfaatan zakat dapat digolongkan kepada empat bentuk: pertama, bersifat konsumtif tradisional yaitu proses dimana pembagian langsung kepada para mustahiq. Kedua, bersifat konsumtif kreatif yaitu proses pengkonsumsian dalam bentuk lain dari barangnya semula, seperti di berikan dalam bentuk beasiswa, gerabah, cangkul dan sebagainya. Ketiga, bersifat produktif tradisional yaitu proses pemberian zakat diberikan dalam bentuk benda atau barang yang diketahui produktif untuk satuan daerah yang mengelola zakat, seperti pemberian kambing, sapi, becak dan sebagainya. Keempat, bersifat produktif kreatif yaitu proses perwujudan pemberian zakat dalam bentuk permodalan bergulir baik untuk usaha program sosial, home industri atau pemberian tambahan modal usaha kecil. Penyaluran zakat secara produktif ini pernah terjadi di zaman Rasulullah saw. Di kemukakan dalam sebuah hadis riwayat Imam Muslim dari Salim bin Abdillah bin Umar dari ayahnya, bahwa Rasulullah saw telah memberikan zakat kepadanya lalu menyuruhnya untuk dikembangkan atau disedekahkan lagi. Dana zakat bukan pemberian sesuap nasi dalam jangka sehari dua hari, kemudian para mustahiq menjadi miskin kembali, tapi dana zakat itu harus memenuhi kebutuhan hidup secara lebih baik dalam jangka waktu yang relatif lama. Zakat merupakan ibadah maaliyah ijtimaiyah yang memiliki posisi yang sangat penting, strategis, dan menentukan, baik dari sisi ajaran maupun sisi pembangunan dan kesejahteraan umat. Zakat dapat memberikan solusi dalam masalah kemiskinan, pengangguran dan pemerataan ekonomi apabila dilakukan secara optimal. Hal ini mengandung pemahaman bahwa zakat harus dikelola dengan baik, karena zakat merupakan salah satu sumber pemasukan dana yang sangat potensial untuk menjadi alternatif bagi pemberdayaan ekonomi umat.
Segurança do paciente: conhecimento e atitudes de enfermeiros em formação
Authors: Figueiredo Rodrigues Gelciane , Salgado Castro Teresa Cristina , Ferreira Vitorio Aline Mirema
Published: December 2018

Identificar o conhecimento e a percepção de estudantes de graduação em enfermagem relacionados ao erro humano no âmbito da segurança do paciente. Trata-se de um estudo quantitativo, descritivo, transversal. Os dados foram coletados em uma Universidade privada no Rio de Janeiro no ano de 2015, por meio de um questionário autoaplicável, com estudantes de enfermagem. A amostra total resultou em 65 participantes. Os resultados apontaram que os estudantes têm conhecimento sobre a temática Segurança do Paciente, porém, quando se trata das atitudes apresentam respostas que não condizem com a literatura no que se refere à comunicação do erro ao paciente e família. Não basta a aquisição de conhecimentos, mas atitudes principalmente que venham contribuir com o cuidado seguro, livre de danos decorrentes de erros. Assim como, para tal premissa deve ser criado um ambiente acadêmico seguro de estímulo aos relatos de erro e dúvidas.
Development and evaluation of a high-fidelity canine laparoscopic ovariectomy model for surgical simulation training and testing
Authors: Chen Chi-Ya , Elarbi Mustafa , Ragle Claude A. , Fransson Boel A.
Published: December 2018

OBJECTIVE To develop and evaluate a high-fidelity simulated laparoscopic ovariectomy (SLO) model for surgical training and testing.

DESIGN Evaluation study.

SAMPLE 15 veterinary students (novice group), 5 veterinary surgical interns or residents (intermediate group), and 6 veterinary surgeons (experienced group).

PROCEDURES Laparoscopic surgery experience was assessed by questionnaire and visual analog scales. Basic laparoscopic skills were assessed with a commercial training model. A commercial canine abdomen model was customized with a high-fidelity simulated canine female genital tract. Each subject's SLO performance (laparoscopic entry, dissection along marked planes, and left ovariectomy) was evaluated by measurement of surgical time and errors (splenic puncture and deviation from dissection marks) and with global and operative component rating scales. Construct and concurrent validity were assessed by correlation of SLO results with self-estimated measures of experience level and with basic laparoscopic skills test results, respectively. Face validity was assessed with a questionnaire completed by intermediate and experienced group participants.

RESULTS 13 participants (3/15, 5/5, and 5/6 in the novice, intermediate, and experienced groups, respectively) completed SLO within the preset time. No difference in errors was found among groups. Completion time was significantly correlated with self-estimated experience level (r = −0.626), confirming construct validity, and with basic laparoscopic skills scores (r = −0.552) and global (r = −0.624) and operative component (r = −0.624) rating scale scores, confirming concurrent validity. Overall mean face validity score was low (64.2/100); usefulness of the model for surgical training received the highest score (8/10).

CONCLUSIONS AND CLINICAL RELEVANCE Results suggested the SLO model may be a useful surgical training tool. Further studies are needed to confirm usefulness of the model in veterinary laparoscopy training.
Thermal inactivation kinetics of Aspergillus oryzae β-galactosidase in concentrated lactose solution
Authors: Illeová Viera , Polakovič Milan
Published: December 2018

Thermal inactivation of a commercial β-galactosidase from Aspergillus oryzae in a 300 g/L lactose solution was studied in the temperature range of 65–75 °C. Lactose exhibited a stabilisation effect when similar inactivation rates as those in lactose solution were observed in a lactose-free solution at temperatures lower by 5°C. Inactivation process in the lactose solution was biphasic. A kinetic model based on the Lumry-Eyring mechanism was proposed and successfully verified. Estimated activation energy values were very different. Rather high activation energy values of the forward reactions were responsible for both the significant change of rate constants and the rate-controlling reaction with temperature. For these two reasons, an increase of the operational lifetime of the enzyme from 7 days at 60 °C to 580 days at 55 °C was predicted.
Fast nonlinear model predictive control of a chemical reactor: a random shooting approach
Authors: Bakaráč Peter , Kvasnica Michal
Published: December 2018

This paper presents a fast way of implementing nonlinear model predictive control (NMPC) using the random shooting approach. Instead of calculating the optimal control sequence by solving the NMPC problem as a nonlinear programming (NLP) problem, which is time consuming, a sub-optimal, but feasible, sequence of control inputs is determined randomly. To minimize the induced sub-optimality, numerous random control sequences are selected and the one that yields the smallest cost is selected. By means of a motivating case study we demonstrate that the random shooting-based approach is superior, from a computational point of view, to state-of-the-art NLP solvers, and features a low level of sub-optimality. The case study involves a continuous stirred tank reactor where a fast multi-component chemical reaction takes place.
The Role of microRNA-15A in the Development of Prostate Cancer – Effects on Cell Proliferation and Pro-Inflammatory Signalling
Authors: Apostolova A. , Sezer L. , Hayrabedyan S. , Todorova Kr.
Published: December 2018

Worldwide prostate cancer is the second leading cause of cancer death among men after lung cancer. MicroRNAs are non-coding, endogenous RNAs and they play a role in tumorigenesis, RNA silencing and post-transcriptional regulation of gene expression. In this study we have investigated microRNA-15a impact on transcription factors cMYB and ETS1 in prostate-carcinoma cell line PC3. The PC3 cells were transfected with a synthetic analogue and inhibitor of microRNA-15a. The study was performed using reverse transcription polymerase chain reaction and flow cytometry methods for assessing the transcript and protein levels of cMYB and ETS1, NFκB stable reporter live cell line. Statistical analysis was performed using One–way ANOVA test. We found that cMYB and ETS1 are up-regulated by the synthetic analogue of microRNA-15a at the transcription and protein level. Transfection with microRNA-15a mimic resulted in NFκB transcription factor activation as found by using the live cell reporter system. There was some opportunistic activity exhibited by the synthetic inhibitor, but less pronounced. Our data suggest that microRNA-15a could participate in prostate cancer progression by modulating cell proliferation and pro-inflammatory signaling and paves a way for further in-depth investigation of the gene regulatory networks underneath.
Optical density of Scots pine wood and climatic conditions in Toruń, Poland
Authors: Pospieszyńska Aleksandra , Koprowski Marcin , Przybylak Rajmund
Published: December 2018

The aim of the studies was to evaluate the usefulness of the microscopic features of wood in characterising the climatic conditions of a period for which only proxy data are available. Samples were taken from historical wood from Koronowo collegiate church and from a living Scots pine tree growing in the Toruń-Wrzosy site. All measurements were performed using ImageJ software. The dendroclimatological analysis was carried out in the program DendroClim2002. The results show a correlation between the microscopic features of wood and climatic conditions. For the period 1951–2000 the maximum optical density of pine wood depends on average May air temperature and June precipitation, with correlation coefficients of −0.32 and −0.29, respectively. A similar correlation was found for mean maximum and minimum temperatures in May; -0.35 and -0.37, respectively. Additional correlations between selected meteorological elements and the maximum optical density of the wood were found using 30-year moving averages and moving intervals.