bluuebunny/crossref_metadata_2025 huggingface dataset:
Laparoscopic extraperitoneal radical cystoprostatectomy: for whom and how?
Authors: Perlin D. V. , Aleksandrov I. V. , Shmanev A. O. , Shamhalov Sh. , Kulikov P. A.
Published: November 2023

Background. Laparoscopic radical cystectomy is an established reliable minimally invasive method for the treatment of muscle-invasive bladder cancer. However, in the elderly and patients with serious comorbidities, laparoscopic radical cystectomy is still associated with high risk of complications. There are only a few reports on the use of extraperitoneal access for laparoscopic radical cystectomy in the literature. At the same time, extensive experience has been accumulated in laparoscopic extraperitoneal radical prostatectomy and retroperitoneoscopic operations on the kidney showing significant advantages of extraperitoneal access. Aim. To present initial results of laparoscopic radical cystectomy through extraperitoneal access in medically ill patients.

Materials and methods. Between 2017 and 2021, extraperitoneal laparoscopic radical cystectomy was performed at the Volgograd Regional Uronephrology Center in four male patients with tumors affecting the bladder, stages T2–T4. All patients had serious comorbidities. In 3 patients, grade G2–G3 muscle-invasive bladder cancer was histologically verified prior to cystectomy. Two of them had invasion in the posterior urethra. One patient was diagnosed with prostate adenocarcinoma (Gleason score 8 (5 + 3)) with invasion into the bladder wall, ureterohydronephrosis and stage IV chronic kidney disease. None of the patients received neoadjuvant therapy: in 2 cases surgeries were emergency due to recurrent hemorrhages, and 3 patients had significantly decreased kidney function.

Results. All operations were performed completely laparoscopically through extraperitoneal access. In 1 case, urine diversion was performed transperitoneally into a colon conduit. Simultaneous retroperitoneoscopic ureterocutaneostomy was performed in two patients: on one side (in a patient with a single functioning kidney) and on both sides, respectively. In a patient with stage V chronic kidney disease and permanent dialysis, bilateral simultaneous retroperitoneal nephrectomies were performed.

In 2 patients, salvage cystectomy was done for recurrent bleeding that couldn’t be managed by conservative methods. The maximum intraoperative blood loss did not exceed 500 mL. Bowel function in all patients was recovered within 24–36 hours after the intervention.

Conclusion. Laparoscopic  extraperitoneal radical cystectomy is a reproducible minimally invasive surgical procedure for bladder cancer treatment that has advantages in terms of postoperative recovery in patients with severe comorbidities. The use of extraperitoneal access may be a rational alternative for salvage cystectomy in male patients. More observations are needed to determine the place of the method in the surgical treatment of muscle invasive bladder cancer.
Impact of using novel antitumor drugs in adult patients with locally advanced or metastatic urothelial carcinoma on reducing cancer mortality in Russia
Authors: Avxentyev N. A. , Alekseev B. Ya. , Andreyashkina I. I. , Makarova Yu. V.
Published: November 2023

Background. Standard first-line therapy options for patients with locally advanced or metastatic urothelial carcinoma (UC) is platinum-based chemotherapy. Currently,  patients  also have access to immune checkpoint inhibitors (ICIs) such as pembrolizumab, nivolumab, and atezolizumab, along with avelumab, which, unlike other drugs in this class, can be used as maintenance therapy after first-line platinum-based chemotherapy.

Aim. To evaluate the effects of using ICIs in treating adult patients with locally advanced or metastatic UC on reducing overall and one-year cancer mortality in Russia.

Materials and methods.  A mathematical model based on overall survival and progression-free survival data from clinical trials has been proposed. This model describes duration of therapy and treatment outcomes for cases of treatment without ICIs (routine clinical practice); with pembrolizumab, nivolumab, and atezolizumab in first and second-line therapy according to real-life clinical practice (current practice); and with avelumab as maintenance  therapy after platinum-based chemotherapy (proposed practice) over a 3-year period. The model was used to estimate the number of lives saved and healthcare system costs when transitioning from historical to current practice, and from current to proposed practice over a three-year horizon, considering the number of locally advanced or metastatic UC patients who may start platinum-based therapy annually in Russia.

Results. Annually, up to 4,182 patients with locally advanced or metastatic UC in Russia can start platinum-based chemotherapy. Compared to  historical  practice, the  use of pembrolizumab, nivolumab, and atezolizumab in the  first and second lines of therapy in accordance with the routine clinical practice allows to reduce mortality from malignant neoplasms by 553 cases over a 3-year horizon. Over the same period, avelumab-based treatment  would additionally save 2,506 lives. Moreover, the cost of saving one life with the use of avelumab amounts to 6.0 million rubles, which is 9 % lower than the cost of saving one life with the use of other ICIs (6.6 million rubles).

Conclusion. The use of avelumab as maintenance therapy after platinum-based chemotherapy in the 1st line in patients with locally advanced or metastatic UC has a significant and quantifiable impact on reducing cancer-related mortality in Russia.
Is there interest of Mexican adults in being prepared should they develop Alzheimer’s or other dementia?
Authors: Marván Ma. Luisa , Castillo-López Rosa Lilia , Onofre-Corredor Dennys , Vargas-Huicochea Ingrid , Álvarez-del-Río Asunción
Published: November 2023

Introduction. Alzheimer's disease, as well as other dementias, cause a progressive deterioration of cognitive functions, preventing patients from making decisions and having control over themselves in an advanced stage of the disease. Objective. To explore some expectations, wishes and preferences in a sample of mature adults should they develop Alzheimer or other dementia. Method. We surveyed 368 mature Mexican adults without dementia using a large survey created by the authors and used in a previous study; data were collected in some public places where mature people were invited to participate. The survey was completed from July 2019 to August 2020. Results. Although most participants had considered they might suffer from dementia in the future, less than half had communicated their wishes to their relatives about future medical treatments in case they could no longer decide for themselves; very few had prepared a written advance directive. Most participants agreed that patients should know their initial diagnosis, mainly to be able to prepare themselves. The main reason given by those who would prefer to hide the diagnosis was to avoid suffering. Discussion and conclusion. Our results highlight the need for health professionals to promote discussion with people about the possibility of suffering from dementia, as well as the importance of making decisions in advance, and letting their relatives know about them.
Impact of menstrual cycle on smoking cessation: A review
Authors: Núñez-Lauriano Mariana , Lira-Mandujano Jennifer , Míguez M. Carmen , Tiburcio Marcela
Published: November 2023

Background. Information on the way menstrual cycle phases can influence the achievement of tobacco abstinence is contradictory. Objective. A scope review was conducted to determine the effect of the menstrual cycle on tobacco abstinence, considering the phases of the cycle, hormone levels, and premenstrual syndrome. Method. A literature search was conducted in Scopus, PubMed, MEDLINE, and PsycINFO databases. Ten articles comparing the phases of the menstrual cycle or analyzing the association between premenstrual syndrome and a withdrawal condition (length of abstinence or withdrawal symptoms) were included. Results. Two main results were identified: 1) there is no difference in withdrawal symptoms and craving between menstrual cycle phases and 2) abstinence rates in the studies were higher during the luteal phase. Discussion and conclusion. The advisability of suggesting that women wishing to quit smoking should begin to do so at the start of the luteal phrase is discussed. However, smoking cessation interventions must consider all the symptoms experienced during the luteal phase.
Energy Efficient Cluster based Routing Scheme for WSN based IoT to Extend Network Lifetime
Authors: Vani S Badiger  , Ganashree.T.S.
Published: November 2023

With the development and advancement of wireless sensor networks (WSN), the emergence of the Internet of Things (IoT) has achieved prominence in the modern era. With the increasing number of connected devices, WSN has become a key factor in the communication component of the IoT. In IoT-based WSN infrastructure, devices are equipped with intelligent sensors that sense the environment to collect data, process data, and deliver information to the sink or base station (BS). WSN-assisted IoT has become a key technology for various data-centric applications such as health care, smart cities, and the military. Sensor nodes in IoT devices are equipped with bound and irreplaceable batteries. An increased number of connected devices face serious issues of energy depletion, maintenance, and load balancing, which might result in device failure. Energy efficiency is considered a vital parameter in the design of an IoT based WSN, and this can be accomplished through clustering and multihop routing techniques. In this paper, we propose an energy-aware multihop routing scheme (EAMRS) for hierarchical cluster-based WSN-assisted IoT. EAMRS considers the improved low-energy adaptive clustering algorithm (I-LEACH) to select optimal cluster heads (CH). During data transmission, multihop routing is involved by considering routing metrics such as residual energy, distance to BS and optimal route choice to balance the energy load. However, conventional routing schemes fail to achieve the flexibility and adaptability prerequisites of load balancing mechanisms. EAMRS decreases computation overhead and restricts energy usage, resulting in a prolonged network lifetime.
Comparative descriptive analysis of socio-demographic status in immunocompetent and immunocompromised patients with mycoses of the skin, hair and nails
Authors: Ivanova Yuliya A. , Klimko Nikolay N. , Khairutdinov Vladislav R. , Ponomarenko Inga G. , Telichko Igor N.
Published: November 2023

BACKGROUND: Despite the achievements of modern medicine, people's susceptibility to fungal infections is only increasing. In this regard, it is extremely important to understand which social factors are most characteristic of people suffering from mycoses of the skin, hair and nails.
AIM: to study the socio-demographic status of immunocompetent and immunocompromised patients with mycoses of skin, hair and nails.
MATERIALS AND METHODS: A multicenter prospective cohort observational study of the social and demographic characteristics of immunocompetent and immunocompromised individuals with mycoses of the skin of hair and nails was conducted. Four groups of patients were formed: immunocompetent persons, persons with diabetes mellitus, patients with autoimmune diseases while taking immunosuppressants, patients with infection human immunodeficiency virus (HIV). A total of 646 people were examined. To ensure the quality of research and information processing, questionnaires were developed to be filled in for each examined patient. At the time of inclusion in the study, data concerning the place of residence and living conditions of patients, their lifestyle, marital status, bad habits and profession were entered into the questionnaires.
RESULTS: Significant differences (p 0.0001) were revealed between the studied socio- demographic characteristics in the study groups. The age of immunocompetent patients with mycoses of skin, hair and nails was 9–14 years lower than the age of immunocompromised. Female persons prevailed in the case of autoimmune diseases ― 71.1%. Harmful habits were registered in 60% of patients with superficial mycoses and HIV. 83.33% of autoimmune patients were married. Urban residents prevailed over rural residents in the case of diabetes mellitus and autoimmune pathology. Persons of manual work professions in 48.48% of cases were identified among patients with HIV infection, which was more than in other study groups.
CONCLUSION: When studying the socio- demographic characteristics of patients with mycoses of skin, hair and nails, significant differences were revealed in all the factors studied. The obtained results indicate the need to develop a personalized approach to the diagnosis, prevention and treatment of these infections.
The effectiveness of photodynamic therapy using a nanocapsulated oligopeptide of 5-aminolevulinic acid in the complex treatment of the genital lichen sclerosus: A case report
Authors: Snarskaya Elena S. , Shnakhova Lidiya M. , Shamilova Lyaman F.
Published: November 2023

Lichen sclerosus et atropicus is an autoimmune dermatosis belonging to the group of localized scleroderma, most often affecting the skin of the anogenital area. The disease is characterized by slow development with chronization, visualized as areas of atrophy and induration of the affected tissues, causes unbearable itching, pain, dysuria, as well as sexual dysfunction in men and women.
The etiology of the disease has not yet been studied. However, genetic predisposition is becoming more likely, given that at least 10% of patients have a family history.
Topical corticosteroids are currently the generally accepted method of treating lichen sclerosus. Other treatments include pharmaceuticals (for example, testosterone, progesterone, tacrolimus, 5-fluorouracil and retinoids), surgical excision, cryosurgery, laser therapy and ultraviolet radiation, but none of these treatments is satisfactory and does not lead to stabilization of the skinpathological process.
A clinical case of complex effective treatment of genital lichen sclerosus et atrophicus by photodynamic photoporation using 5-aminolevulenic acid in a 19-year-old patient with a severe course of the disease, early manifestation in the neonatal period and a total vulvar skin lesion is presented.
Microbiological monitoring in a urological hospital as a method for control of antibiotic resistance of uropathogens
Authors: Slesarevskaya Margarita N. , Spiridonova Anna A. , Mkrtchyan Arsen S. , Kruchinova Sofya O. , Petrov Sergeii B. , Al-Shukri Adel S. , Kuzmin Igor V. , Ponomareva Yulia A. , Reva Sergeii A. , Gorelov Dmitriy S.
Published: November 2023

BACKGROUND: A rational choice of antibacterial therapy for hospital infections is a condition for successful treatment of patients.
AIM: The aim of this study is a comparative assessment of the species composition of pathogens and the level of their resistance to antibacterial drugs in patients with complicated urinary tract infections in a urological hospital.
MATERIALS AND METHODS: An analysis of the results of microbiological examination of urine samples from 1317 patients (795 men and 522 women) with complicated urinary tract infection who were hospitalized in a urology clinic during the period 2020–2021 was carried out.
RESULTS: Gram-negative microflora was detected in 703 (53.4%) patients, gram-positive microflora in 531 (40.3%) patients and mixed microflora in 83 (6.3%) patients. Among gram-negative bacteria Escherichia coli (23.1%) and Klebsiella pneumoniae (16.1%) were predominate, Pseudomonas aeruginosa (4.9%) and Proteus mirabilis (2.8%) were less frequently detected. A high frequency of detection of gram-positive microflora of the genera Enterococcus (21.4%) and Staphylococcus (12.7%) was noted. When compared with the results of a similar study from 2018 to 2020 there is a decrease in the detection rate of E. coli from 28.2% to 23.1%. Antibiotic resistance of hospital strains of uropathogens varies significantly for different antimicrobial drugs. Most often resistance to representatives of three or more groups of antibiotics was observed in K. pneumoniae (46.6%), less commonly in E. coli (19.5%) and rarely in Enterococcus spp. (5.9%).
CONCLUSIONS: Microbiological monitoring allows us to assess the etiological structure and level of antibiotic resistance of nosocomial urinary tract infections. Local data on the sensitivity of microorganisms to antibacterial drugs make it possible to rationally carry out perioperative antibiotic prophylaxis and prescribe empirical therapy for urinary tract infections before obtaining the results of a microbiological study.
Personalized approach to pharmacotherapy of overactive bladder
Authors: Kuzmin Igor V.
Published: November 2023

The article provides an overview of modern approaches to pharmacotherapy of overactive bladder. It has been shown that the choice of drug therapy for overactive bladder should be made taking into account the pathophysiological mechanisms of the development of the disease, the characteristics of its clinical course, as well as the potential risks of developing side effects of treatment. A pathogenetic rationale for the choice of treatment tactics for different categories of patients is presented, including those with a hypersensitive bladder, bladder outlet obstruction, neurological and geriatric patients. The pharmacological properties of the β3-adrenergic receptor agonist mirabegron are described, which provide high efficacy and a favorable safety profile in the treatment of patients with overactive bladder. The practical issues of prescribing mirabegron in various clinical situations are considered.
Spinal Interneuron Transplantation to Repair the Injured Cervical Spinal Cord
Authors:   , Fortino Tara , Dougherty Kimberly J. , Lane Michael A
Published: November 2023

Cervical spinal cord injuries directly compromise the phrenic motor network resulting in diaphragm paralysis and impaired breathing. Anatomically, injuries at this level result in extensive cell loss including phrenic interneurons and phrenic motorneurons. Despite these consequences, some limited plasticity typically occurs weeks post-injury shown by increased interneuronal integration with the damaged phrenic network and modest improvement of diaphragm recovery. In an effort to harness and enhance this plasticity, we have engineered stem-cell derived spinal interneurons that can be transplanted directly into the injured spinal cord. We recently found that transplanting neural precursor cells (NPCs) comprised of spinal neural precursors promotes phrenic recovery post-SCI. Building on these initial results, the present dissertation tests the hypothesis that enriching these neural precursors with stem cell derived V2a and V0 spinal interneurons (SpIN), will further enhance diaphragm recovery. Adult, female, Sprague Dawley rats received SpIN-enriched NPC transplants sub-acutely (1 week) following a lateralized, mid-cervical contusion injury. Donor SpINs were engineered to express the hM4Di receptor, allowing for inhibition of these cells with application of clozapine. Multi-electrode array recordings were used to confirm inhibition of donor SpINs in vitro prior to transplantation. Intraspinal clozapine application during diaphragm electromyography was used to silence transplanted V2a SpINs, resulting in decreased diaphragm output following drug delivery. Pseudorabies virus tracing of the injured phrenic network was used to show synaptic integration of donor NPCs and V2a and lack of connectivity of V0 SpINs with host phrenic circuit. Ipsilateral diaphragm activity was unaffected by transplantation of NPC enriched with V0 SpINs while there was an increase in the contralateral diaphragm output. Future studies will look at labeling connectivity from the contralateral hemidiaphragm, and further RNAscope experiments to quantify anatomical connections made by donor SpINs. This research provides the first in depth assessment of how these donor SpIN populations contribute to phrenic recovery.
The Benefits of Kinesiotaping in Physical Activity Practitioners: Integrative Review
Authors: Fengler Adriane , Andraus Rodrigo Antonio Carvalho
Published: November 2023

AbstractThe practice of physical activity results in physical, mental, social and important health benefits by preventing diseases, for which motor skills are needed and there are some factors such as large ranges of motion, physical contact, muscle tension that are exerted during physical practice that can cause significant injuries. Injury prevention in physical activity practitioners or athletes includes identifying modifiable risk factors, offering effective preventive training programs and establishing safe criteria to return to sport. With the advancement of technology to rehabilitate athletes, physical therapy has used the method of using taping to improve the function of the extremities and correct muscle imbalances that could lead to possible withdrawal from their activities. The objective was to identify the benefits of applying the kinesiotaping method in individuals who practice physical activity. A search was carried out in the Pubmed, Web Science, Scielo indexes, and the research period was from July to August 2022. 15 articles resulted which were read in full to compose this integrative review. The study showed different forms of taping application in physical activity practitioners, whether for rehabilitation or injury prevention.
Keywords: Exercise. Athletic Tape. Health Promotion.
ResumoA prática da atividade física resulta em benefícios físicos, mentais, sociais e importante para saúde prevenindo doenças, para isso são necessárias habilidades motoras e existem alguns fatores como grandes amplitudes de movimentos, contato físico, tensão muscular que são exercidas durante a prática física que podem ocasionar lesões significativas. A prevenção de lesões em praticantes de atividade física ou atletas inclui identificar fatores de risco modificáveis, oferecer programas de treinamento preventivo eficazes e estabelecer critérios seguros de retorno ao esporte. Com o avanço da tecnologia para reabilitar atletas, a fisioterapia tem utilizado o método do uso de taping para melhorar a função das extremidades e corrigir desequilíbrios musculares que poderiam levar a possíveis afastamento de suas atividades. O objetivo do estudo foi identificar os benefícios da aplicação do método kinesiotaping em indivíduos que praticam atividade física. Realizou-se uma pesquisa nos indexadores Pubmed,Web Science, Scielo, o período de busca foi de julho a agosto de 2022 artigos nos idiomas inglês e português. Resultaram 15 artigos lidos na íntegra que compusseram esta revisão integrativa. O estudo mostrou diversas formas de aplicação do taping em praticantes de atividade física sendo para reabilitação ou para prevenção de lesões.
Palavras-chave: Exercício Físico. Bandagem Elástica. Promoção em Saúde.
Cortıcobasal Degeneratıon and Posterıor Cortıcal Atrophıa: a Case Report
Authors: Doğan Fatıma Zehra , Altuntaş Onur
Published: November 2023

Abstract Corticobasal degeneration is an atypical Parkinson's syndrome characterized by cerebral cortical findings such as apraxia or loss of cortical sensation. The aim of this study is to show the effect of occupational therapy interventions in a patient followed up with a diagnosis of corticobasal degeneration and posterior cortical atrophy. The study included by a 59 year old female patient. After the initial evaluation, she received an Occupational Therapy intervention for one hour, once a week, for eight weeks in our department. A final assessment was made at the end of eight weeks. As a result of the evaluations, significant improvements were observed in the functional independence scale, mini mental state test, and tinetti test. There is a decrease in the geriatric depression scale, but it is still at the border of depression. Progress in sensory evaluations is not significant despite the intervention, but it should be noted that the person has a progressive chronic disease. In conclusion, although corticobasal degeneration and posterior cortical atrophy are progressive neurodegenerative disorders, slowdowns in the course of the disease can be observed with planned person-centered rehabilitation interventions. The importance of early rehabilitation in such degenerative disorders can be emphasized and it is recommended to add occupational therapy interventions to these treatment programs.
Keywords: Corticobasal Degeneration. Occupational Therapy. Case Reports.
Resumo A degeneração corticobasal é uma síndrome de Parkinson atípica caracterizada por achados corticais cerebrais, como apraxia ou perda de sensibilidade cortical. O objetivo deste estudo é mostrar o efeito de intervenções de terapia ocupacional em um paciente acompanhado com diagnóstico de degeneração corticobasal e atrofia cortical posterior. O estudo incluído por uma paciente do sexo feminino de 59 anos. Após avaliação inicial, recebeu intervenção de Terapia Ocupacional por uma hora, uma vez por semana, durante oito semanas em nosso serviço. Uma avaliação final foi feita ao final de oito semanas. Como resultado das avaliações, foram observadas melhorias significativas na escala de independência funcional, mini teste do estado mental e teste de tinetti. Há uma diminuição na escala de depressão geriátrica, mas ainda está na fronteira da depressão. O progresso nas avaliações sensoriais não é significativo apesar da intervenção, mas deve-se notar que a pessoa tem uma doença crônica progressiva. Em conclusão, embora a degeneração corticobasal e a atrofia cortical posterior sejam distúrbios neurodegenerativos progressivos, abrandamentos no curso da doença podem ser observados com intervenções planejadas de reabilitação centradas na pessoa. A importância da reabilitação precoce em tais distúrbios degenerativos pode ser enfatizada e recomenda-se adicionar intervenções de terapia ocupacional a esses programas de tratamento.
Palavras-chave: Degeneração Corticobasal. Terapia Ocupacional. Relatos de Caso.
Evaluación de disponibilidad y preparación de Unidades de Salud Familiar del Eje Sur de Paraguay para la atención a personas con hipertensión arterial y diabetes en 2022
Authors: Giménez Caballero Edgar , Amarilla María Gloria , González De Mestral César , Acosta José Carlos , Báez Ariel , Arévalos Eleno , Ortigoza Mónica Patricia , Martínez Juan María , Villalba Juan Angel , Oliveira Héctor Daniel , Zapata Paola
Published: November 2023

Paraguay se propuso alcanzar cobertura y acceso universal mediante redes basadas en Atención Primaria de la Salud con Unidades de Salud Familiar (USF). Un desafío es abordar las enfermedades no transmisibles, causantes de mortalidad prematura en el país. El objetivo del estudio fue evaluar la capacidad de las USF para la atención de personas con hipertensión arterial y diabetes. El diseño fue observacional, descriptivo, transversal con componente analítico. Incluyó a 172 USF de las 4 Regiones Sanitarias que conforman el Eje Sur. Se adaptó el método de evaluación SARA de la OMS con 75 indicadores trazadores, aplicando un cuestionario dirigido a profesionales de salud entre noviembre y diciembre de 2022. Se calculó índices de síntesis de disponibilidad y preparación que se midieron de 0 a 1. La mediana del índice de disponibilidad fue 0,71, el de preparación 0,76 y el índice SARA USF-DM/HTA 0,74. La disponibilidad de medicamentos fue la principal brecha seguida de equipamiento básico para neuro exploración, equipos de comunicación e internet. En la preparación resultaron con menor desempeño actividades de supervisión y evaluación, así como la gestión de casos en la red de servicios. Solo el 44,2 % de las USF tuvo un desempeño de disponibilidad y preparación suficiente. Las USF rurales tuvieron menor desempeño que las urbanas. Hubo diferencia significativa entre las regiones sanitarias p<0,001. En conclusión, las USF presentaron limitaciones para la atención de personas con diabetes e hipertensión en estas regiones del país.
A study to assess the maternal and perinatal outcome of postdated pregnancy at a tertiary care institution of Eastern India
Authors: Saurabh Suvidha
Published: November 2023

Background: Post term pregnancy has been defined as a pregnancy that persists beyond 294 days or 42 weeks of gestation. It most likely occurs in less than 5% gestation and has been associated with increased perinatal mortality rate. There is a strong body of evidence that the induction of labour at term and prior to 42 weeks of gestation is associated with reduction in perinatal complications without an associated increase in CS rates.
Methods: This observational study was carried out in obstetrics/gynaecology department of ESIC Medical College and Hospital, Bihta. All the primi or multi gravida beyond the expected date of delivery and coming under the inclusion criteria were taken. Taking in consideration about the incidence of cases of post term deliveries last year, we are getting 6 to 7 cases every month. So,70 cases in 1 year of study duration was taken from October 2022 to September 2023.
Results: This observation study showed that the incidence of postdated pregnancy was higher in primi gravida. Incidence of fetal distress and NICU admissions increased as the period of gestation increases.
Conclusions: Post dated pregnancy was associated with perinatal complications like fetal distress, meconium aspiration syndrome and fetal asphyxia. There was increased risk of obstetric complications like postpartum haemorrhage, perineal tear, cervical tear and shoulder dystocia. Management of postdated pregnancy is a challenge to obstetrician and policies regarding induction of labour beyond expected date of delivery can reduce untoward complications.
Effectiveness of riboflavin as prophylaxis of paediatric migraine
Authors: A. R. Kumaran Mithun
Published: November 2023

Paediatric migraine headache is a common condition for which there is no general consensus on the choice of prophylactic. Riboflavin has been considered as a potential prophylactic which is well tolerated. This review examines the current literature regarding the efficacy of riboflavin as a prophylactic. There have been mixed results from both retrospective studies as well as randomised controlled trials. Whilst the adverse effect profile is minimal compared to other migraine prophylactics, further well-designed studies with larger sample sizes and longer follow-up are required.
Dental stem cells and their applications in pediatric dentistry
Authors: Aldomyati Roaa M. , Alghamdi Hussain K. , Alzahrani Eman I. , Alkhudhayr Lama M. , Binthabit Sultanah M. , Subahi Jumana H. , Alzahrani Fawaz H. , Alsulaimani Mawaddah N. , Algarni Shihnaz M. , Abdulaziz Mariam G. , Almusayyab Othoob T.
Published: November 2023

Regenerative medicine has garnered significant attention due to its transformative impact on disease management and the restoration of optimal bodily functions. Stem cells, a cornerstone of regenerative medicine, are particularly renowned for their remarkable capacity to facilitate tissue regeneration and repair, revolutionizing modern healthcare by offering diverse treatment avenues for multiple conditions. Dental pulp stem cells (DPSCs), a subset of postnatal stem cells, are especially noteworthy for their extensive proliferation and ability to differentiate into various specialized cell types. In the realm of pediatric dentistry, there exists a pressing need for advancements in regenerative medicine. Thorough research in this domain has the potential to propel evidence-based pediatric dentistry, ensuring that children receive tailored, high-quality care. Stem cells hold immense promise in pediatric dentistry by offering less invasive and regenerative solutions for a range of childhood dental issues and congenital anomalies. This research, initiated on 04 October 2023, was instigated following an exhaustive review of existing literature utilizing databases like PubMed, Web of Science, and Cochrane. The literature search encompassed a wide array of medical terminologies. Dental stem cells are categorized into four major types: DPSCs, stem cells from human exfoliated deciduous teeth (SHED), stem cells of the apical papilla (SCAP), and periodontal ligament stem cells (PDLSCs). Pediatric dentistry, encompassing endodontics, orthodontics, periodontics, and the treatment of craniofacial defects, stands to benefit significantly from the potential of dental stem cells. The preservation of dental pulp stem cells extracted from deciduous and permanent teeth through tooth banking offers a source for future regenerative therapies. The preservation process involves multiple comprehensive steps. In summary, dental stem cells present a promising avenue within pediatric dentistry, offering multifaceted applications ranging from pulpal regeneration and dentin repair to orthodontic support and the treatment of craniofacial anomalies.
The role of MRI in assessing cognitive impairment changes
Authors: Ahmad Doha Jamal , Alghamdi Ahmed Abdullah , Alshahrani Nada Aeydh , Albarrati Fatimah Mofareh , Alshehri Sarah Ali , Talbi Nouf Essa , Alshehri Mohammed Fadhel , Alomani Najla Juma , Alshehri Israa Hamdan , Hutaylah Hussain Hatim Al , Alghanmi Mohammad Dakhilalla
Published: November 2023

Aging brings about various changes in the brain, leading to cognitive alterations that are increasingly relevant with extended life expectancy. Dementia, characterized by chronic cognitive impairment, is on the rise due to longer life expectancy, imposing a substantial burden on healthcare systems. Dementia encompasses conditions like Alzheimer's disease (AD), vascular dementia (VaD), Lewy body dementia (LBD), and frontotemporal dementia, each with its distinct symptoms and progression. Magnetic resonance imaging (MRI), especially 3T MRI, plays a crucial role in monitoring and diagnosing dementia, aiding in patient selection for emerging therapies. Study involves a comprehensive literature search without restrictions on date, language, age/publication type. Dementia can be divided into neurodegenerative and nondegenerative categories, with AD being the most prevalent. Diagnosis relies on clinical evaluation, supported by neuroimaging techniques like MRI. Various MRI findings, such as cerebral atrophy, microbleeds, white matter hyperintensities, lacunes, and strategic infarcts, offer insights into dementia-related brain changes. These findings facilitate early diagnosis, prognosis, and treatment monitoring, with standardized assessment tools and volumetric analysis enhancing diagnostic accuracy. As life expectancy continues to rise, MRI's role in assessing cognitive impairment changes becomes increasingly vital in addressing the growing challenge of dementia.
Phytocompositions of ayurvedic medicine in the restoration of menstrual health in women of early reproductive age who have survived moderate and severe form of COVID-19
Authors: Nosenko O.M. , Moskalenko T.Ya. , Chaykivska E.F. , Suan Ni Din Tkhi
Published: November 2023

Research objectives: to evaluate the effectiveness of phytotherapy in the treatment of menstrual health disorders in women of early reproductive age after a moderate and severe form of the coronavirus disease.Material and methods. 104 women of early reproductive age with menstrual health disorders that occurred 3 months later after moderate or severe COVID-19 were under observation and 34 gynecologically and somatically healthy women of the control group who did not suffer from COVID-19. Female patients with COVID-19 were randomly divided into two groups: the main group (n=53) and the comparison group (n=51). The performed examination included: study of complaints, general and gynecological anamnesis, physical and gynecological examination, ultrasound examination of pelvic organs, determination of hormonal profile. All patients with COVID-19 received a comprehensive rehabilitation program, which included diet therapy, vitamin and mineral complexes, psychotherapy. In addition to the complex rehabilitation program patients of the main group received ayurvedic phytocompositions Femicycle or Femimens for 6 months.Results. It has been established that the moderate and severe course of the coronavirus infection affects the reproductive system of early reproductive aged women and leads to menstrual health disorders, among which irregular menstruation, premenstrual syndrome and dysmenorrhea dominate. Levels of pituitary, adrenal, ovarian and thyroid serum hormones were within the reference norm in most cases, but have statistically significant deviations from similar indicators of healthy control women who did not have COVID-19. One-third of women of early reproductive age after moderate to severe COVID-19 had elevated prolactin levels. Ayurvedic phytocompositions Femicycle and Femimens in a comprehensive rehabilitation program for post-COVID menstrual health disorders led to a faster recovery of menstrual health and a full hormonal recovery.Conclusions. Ayurvedic phytocompositions Femicycle and Femimens are effective and safe naturopathic drugs for restoring menstrual health in women of early reproductive age after experiencing moderate to severe COVID-19.
Preservation of the reproductive health of military women: global experience and realities of Ukraine
Authors: Antypkin Y.H. , Lurin I.A. , Tatarchuk T.F. , Kosei N.V. , Yakimets V.M. , Nazarenko O.Y. , Krysenko T.E. , Bondarenko Y.M.
Published: November 2023

A review of world literature and Ukrainian researches on the most common requests to gynecologists among military women, on the structure of pathology and treatment methods was made. Special attention is paid to the hormonal contraception, namely combined oral contraceptives (COCs) in the usual and continuous regime (avoiding the hormone-free interval) and the levonorgestrel-releasing intrauterine systems (LNG-IUDs).Cases of global practice of using COCs in extended regimen were considered, which showed that 47.2% of 1156 women chose a prolonged regimen of COCs, the main reason for this was the desire to avoid symptoms associated with menstruation. We consider this option very positive for military women, because some studies show that military women who took COCs in a continuous regimen were almost twice as favorable to their reception as those who used them in a regular mode.The positive aspects of the LNG-IUDs use in military women are presented, as a factor in the prevention of abnormal uterine bleeding, reducing the risk of iron deficiency in case of possible blood loss, and reducing the intensity of dysmenorrhea as a negative factor in the military conditions.Ways to increase compliance between a gynecologist and a military woman are also considered, using the example of global studies, which prove that insufficient awareness of patients about the possible ways and positive effects of using COCs in extended regimen reduced patients’ commitment to choosing new regimens.Conclusions. In today’s realities, the gynecological service in our country faces a number of new problems that require a strategic approach and solution. World practice and national studies prove that stress-induced hormonal disorders in military women, such as abnormal uterine bleeding, menstrual cycle disorders, dysmenorrhea, are negative factors in combat conditions, require the attention and resolution by doctors. One of the options for solving this problem can be the appointment of COCs according to the usual and extended scheme or appointment of LNG-IUDs.
Exact sequence matches in genomic studies
Authors:   Institute for Advanced Studies, Sevastopol State University, Sheinman Michael
Published: November 2023

The purpose of this article is to review usage of exact sequence matches in different field of genomic studies. Methods. The presentation is built in the form of a brief review of clearly non-exhaustive list of works in which the authors inferred biological knowledge using statistical properties of exact matches between different genomic texts or self-matches along the same genomic sequence. Results. Often, in genomic studies, different genomic loci exhibit different statistical properties, while their boundaries are not known a priory. In such cases we conclude that studying statistical properties of exact sequence matches is a useful alternative to other methods, for instance, based on arbitrary-size (non-)sliding windowing of the genome. Conclusion. This review demonstrates that exact sequences matches are not only an important auxiliary alignment step, but also helpful in other contexts. Their statistical properties are relatively easy to calculate analytically or numerically under various assumptions and compare to empirical data, validating models and fitting the models’ parameters.
INTERDISCIPLINARY TECHNOLOGIES OF THE THEORY AND PRACTICE OF MARKETING AND MANAGEMENT PSYCHOLOGY
Authors: Shmagina V. V.
Published: November 2023

The article examines the presence of interdisciplinary technologies in the theory and practice of marketing and management psychology. It is substantiated that interdisciplinary technologies are used in practical activities using interdisciplinary theoretical knowledge at the intersection of sciences that have points of contact and are aimed at achieving common strategic goals. It is substantiated that the integration of theoretical knowledge and practical skills within the framework of marketing and management psychology comprehensively reveals the meaning of the same concepts, methods, tools, and allows to create modern interdisciplinary marketing technologies.
The presence of interdisciplinary connections, which are based on an interdisciplinary approach and the complexity of knowledge from individual academic disciplines or elements of disciplines, and are actively used by various sciences that have a common interest in several directions, has been proven. This approach allows you to use various integrative theoretical approaches and practical methods in marketing and management psychology.
It was found that the interdisciplinary connection between the theory and practice of marketing and management psychology is formed on the basis of management of traditional and modern concepts: strategic marketing, marketing, emotional marketing, management psychology, management of interaction with consumers, branding, marketing - MIX, company promotion and of the product to consumer markets. It is substantiated that in all modern marketing functions there are interdisciplinary connections of marketing and management psychology. It has been proven that modern marketing in practice actively uses technologies based on interdisciplinary connections and interdisciplinary approaches from marketing and management psychology, which is reflected in emotional marketing. The concept of business and marketing technologies is considered. It is proposed to introduce the concept of interdisciplinary technologies and the concept of marketing interdisciplinary technologies, which are based on interdisciplinary technologies, marketing and management psychology.
Investigation into the Impact of L-Shaped RC Shear Wall Placement with Openings on the Behavior of Medium-Rise Buildings
Authors: Merabti Salem , Bezari Salah , Laari Abdelkadir Aymen , Khachouche Aboubaker
Published: November 2023

This article aims to investigate the impact of regular openings in L-shaped reinforced concrete (RC) shear walls located at building corners. A comparison of different buildings and an estimation of the optimal percentage of openings were conducted. To accomplish this, various wall models, with and without openings, underwent numerical simulations using the ETABS program. The research focused on medium-rise ten-story buildings with opening rates of 0%, 15%, 20%, 25%, 30%, and 35% in the X and/or Y direction under high seismic loading conditions (Zone-III) following the Algerian Paraseismic Regulations (RPA 99/version 2003). The findings of this study indicate that openings have a noticeable impact on the overall behavior of buildings and on the shear wall's capacity to withstand earthquakes. However, opening ratios of 20.8%, 30%, and 31.8%, depending on the direction, are considered optimal opening percentages for L-shaped shear walls. These percentages ensure a suitable balance between architectural functionality and the effective structural performance of L-shaped shear walls. Thus, it is important to consider the placement of openings in the design of reinforced concrete structures braced by shear walls.
AL-WASATHIYYAH UNTUK GEN-Z: PERSPEKTIF HABIB HUSEIN JA'FAR AL-HADAR
Authors: Annisa Annisa
Published: November 2023

Abstract: The concept of al-wasathiyyah has now become the direction or school of Islamic thought for the benefit of the Islamic world at this time. This shows that Muslims should take the middle way, not to be extreme and not to be fanatic in religion. This research uses qualitative methods with library research. Data was collected using exploratory methods, interpretation, and analysis. After the data is collected, it is then analyzed using a descriptive content analysis technique. The results of the research found are Habib Husein Ja'far al Hadar's thoughts in conveying wasathiyyah is very necessary considering the many threats of radicalism, racism and fanaticism, especially the Z-gen which is easily provoked. In the social, cultural and religious context, it is important for Gen-Z to understand and respect existing diversity, uphold the values of moderation in religion, and work together in creating a harmonious and tolerant environment. From Habib Ja'far's delivery, it was very easy for various groups to accept. The media that he often uses in preaching is social media.Keywords: Al-Wasathiyyah, Habib Ja’far, Gen-Z. Abstrak: Konsep al-wasathiyyah saat ini telah menjadi arah atau aliran pemikiran Islam untuk kepentingan dunia Islam pada saat ini. Hal ini menunjukkan bahwa hendaknya umat Islam mengambil jalan tengah, tidak ekstrim dan tidak juga selayaknya bersikap fanatik dalam beragama. Penelitian ini menggunakan metode kualitatif dengan studi pustaka (library research). Data dikumpulkan menggunakan metode eksploratif, interpretasi, dan analisis. Setelah data terkumpul, lalu dilakukan analisis menggunakan teknik descriptive analysist content (analisis deskriptif konten). Hasil penelitian yang ditemukan adalah pemikiran Habib Husein Ja’far al Hadar dalam menyampaikan tentang wasathiyyah sangat diperlukan mengingat banyaknya ancaman radikalisme, rasisme dan fanatisme terkhusus gen-Z yang mudah terprovokasi. Dalam konteks sosial, budaya, dan agama, penting bagi gen-Z untuk memahami dan menghormati keragaman yang ada, menjunjung tinggi nilai-nilai moderasi dalam beragama, dan bekerja sama dalam menciptakan lingkungan yang harmonis dan toleran. Dari penyampaian Habib Ja’far sangat mudah di terima berbagai kalangan. Adapun media yang sering ia gunakan dalam berdakwah adalah media sosial.Kata Kunci: Al-Wasathiyyah, Habib Ja’far, Gen-Z.
Análise do ensino médio brasileiro com base em indicadores educacionais
Authors: Gusmão Fábio Alexandre Ferreira
Published: November 2023

Este artigo tem como objetivo desvelar o ensino médio a partir da observação, descrição e interpretação da realidade educacional do ensino médio brasileiro, tendo como base os indicadores do desempenho escolar dos alunos (avaliações realizadas pelo SAEB) e do processo educacional (aprovação, reprovação, abandono, repetência, defasagem idade-série e proporção dos alunos matriculados de acordo com a idade escolar). A pesquisa caracteriza-se como de abordagem quantitativa e utilizou a análise estatística como método de investigação. Concluiu-se que o baixo nível de desempenho escolar apontado pelo SAEB é consequência direta e/ou indireta da desigualdade econômica social e educacional que afeta, principalmente, os estudantes das escolas públicas e alunos oriundos de famílias mais vulneráveis, em condição de pobreza, desigualdade e marginalizados. Além disso, inviabiliza a promoção da justiça educacional, visto que afeta o desempenho, o êxito e a trajetória escolar dos concluintes da educação básica.