bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Antinociceptive Activity of Newly Modified Amine Analogs
of Phencyclidine in Mice
Authors: Sobhanian Seyed Ali , Shokrollahi Maryam , Samadizadeh Marjaneh , Khalili Mohsen , Ahmadi Abbas
Published: October 2021

Background:

Phencyclidine (PCP, I) and its substituted analogs are significant and
broadly abused psychotomimetic drugs that affect the central nervous system. They possess many
pharmacological properties due to the presence of specific receptors in the brain.

Aim and Objective:

Methyl group, despite strong electron-donating and characters of dipole moments,
was placed on various positions of phenyl and amine moieties of phencyclidine along with
the substitution of benzylamine, piperazine, and aniline derivatives in place of piperidine ring of
phencyclidine to create novel compounds of the core with analgesic properties.

Material and methods:

For evaluation of the analgesic activities of newly synthesized compounds,
they were screened by tests of tail immersion (thermal) and formalin (chemical) pains. The obtained
data with the control and PCP groups were also compared.

Results:

The outcomes indicated that some new compounds have more antinociceptive effects than
PCP in tail immersion and formalin tests. In the tail immersion test, the methyl piperazine analog
(III) shows more efficacy than others. In the formalin test, none of the compounds are as effective
as phencyclidine at the earliest time-point, but compounds IV and V show effectiveness during the
second stage of formalin pain.

Conclusion:

It can be concluded that the methyl-piperazine analog of phencyclidine was the best
candidate to decrease acute thermal pain, and benzylamine derivatives were suitable candidates to
reduce chemical pains.
A NOD-Like Receptor Signaling-Based Gene Signature Identified as a
Novel Prognostic Biomarker for Predicting Overall Survival of Colorectal
Cancer Patients
Authors: Qi Xin , Zuo Jiachen , Yan Donghui , Hu Guang , Wang Rui , Chen Jiajia , Fu Jiaolong
Published: October 2021

Background:

Colorectal Cancer (CRC) is the most frequently diagnosed gastrointestinal
tract malignant tumor worldwide, which is closely associated with distant metastasis and poor prognosis.
Due to high degree of heterogeneity, reliable prognostic biomarkers are urgently needed to guide the
therapeutic intervention of CRC patients.

Objective:

The present study aimed to develop a NOD-Like Receptors (NLRs) signaling-based gene
signature that can successfully predict the overall survival of CRC patients.

Methods:

Firstly, differentially expressed NLR signaling-related genes were identified between primary
and metastatic human CRC samples. Genes with prognostic value were then screened through univariate
Cox regression analysis. Next, the NLR signaling-based prognostic signature was constructed by
LASSO-penalized Cox regression analysis, and its predictive ability was further confirmed in an independent
cohort. Furthermore, functional studies including GO, GSEA, ssGSEA and chemotherapeutic
response analyses were performed to explore the role of the NLR signaling-based signature in CRC
pathogenesis and therapy.

Results:

The established prognostic signature that consisted of 7 NLR signaling-related genes can effectively
stratify the high-risk and low-risk CRC patients in both training and validation cohorts. Moreover,
the signature proved to be an independent indicator of overall survival in CRC patients. Functional annotation
and chemotherapeutic response analyses showed that the signature was closely associated with
immune status and chemotherapeutic sensitivity of CRC patients.

Conclusion:

The novel NLR signaling-based gene signature could serve as a potential tool for survival
prediction and therapeutic evaluation, thereby contributing to the personalized prognostic management
of CRC patients.
Breastfeeding Promotion and Nursing Care for Infants with Cleft Palate and/or Cleft Lip in Northeastern Craniofacial Center, Thailand
Authors: Namchaitaharn Suntaree , Pimpiwan Naphatchamon , Saengnipanthkul Suchaorn
Published: October 2021

Background:

The common feeding problems in infants with Cleft Palate (CP) and/or Cleft Lip and Palate (CLP) are the inability to suck and swallow breastmilk. Difficulties in feeding may compromise normal growth and disrupt the bonding process.

Objective:

To evaluate the treatment and breastfeeding rate in infants with CP and CLP.

Methods:

A retrospective study of infants with CP and CLP who were admitted to the postpartum ward between July 2017 and June 2019 was conducted. Demographic data, type of feeding, nursing activities, and duration of breastfeeding after discharge were collected.

Results:

A total of 35 infants were included in the study. Twenty-seven cases were non-syndromic complete CLP (77.2%). On admission only 15 infants (42.8%) received breastmilk and alternative feeding techniques were applied for 26 (74.3%) infants. Breastfeeding promotion and nursing care were provided to mothers and infants by an interdisciplinary team at the Craniofacial Center. The median Length of Stay (LOS) was 8 days (range 5-9 days) and infants born at the affiliated hospital (inborn) had a significantly shorter LOS compared to infants referred from other health centers (p=0.019). None of the inborn groups received infant formula. The breastfeeding rate in all groups was 100% at discharge. Exclusive breastfeeding rates at 2-, 4-, and 6-months follow-up were 82.8%, 42.8%, and 31.4%, respectively.

Conclusion:

Breastfeeding promotion, education, and nursing care from an interdisciplinary team resulted in an improved ability of mothers to breastfeed infants with CLP, particularly in non-syndromic CLP. The exclusive breastfeeding rate after 6-months in this study was higher than in previous studies.
Efectos de un programa de intervención sobre el desarrollo del pensamiento crítico en universitarios chilenos
Authors: Betancourth Zambrano Sonia , Martínez Daza Viviana , Tabares Díaz Yuranny Alejandra , Castillo Leyton Ana
Published: October 2021

Introduction: critical thinking is a cognitive process oriented to the interpretation, inference, evaluation, analysis and reflection of context situations, through knowledge and intelligence, to arrive effectively at the most reasonable and justified position on an issue. Objective: to analyze the effects of an intervention program based on chain meeting, transformative triangulation and controversy about critical thinking in students of the social work career of a Chilean university. Materials and Methods: the study was framed in the quantitative paradigm, of quasi-experimental design with preprogramme and post-test with a single group. The sample was made up of 33 university students. The intervention program consisted of a total of six sessions, in which three critical thinking development strategies corresponding to chain meeting, transformative triangulation and controversy were implemented; It also included face-to-face and virtual counseling. Results: it was found that there are positive effects on the critical thinking of the participating students, after the development of the intervention program. Conclusions: Critical thinking development strategies promote the construction of knowledge, the ability to adopt a posture, the self-assessment of one’s own thinking and the recognition of divergent points of view.
Participación política de la mujer: Democracia en la construcción de paz
Authors: Bolaño García Beatriz H , De la Hoz del Villar Katrim
Published: October 2021

Introducción/objetivo: Este texto desarrolla aspectos sustanciales sobre la participación política de la mujer colombiana en todos sus órdenes, como método o fórmula para garantizar el ejercicio fundamental del derecho a elegir y ser elegida en el marco de un Estado democrático. Materiales y métodos: Para tal efecto, se realiza un análisis del marco jurídico protector que propende por la participación de la mujer en asuntos de gobierno y la administración, así como la promoción de la participación política de esta en tanto fórmula para la construcción de paz con enfoque territorial. Resultados: Se esboza la normatividad legal que introduce acciones afirmativas a favor de las mujeres como lo son: las cuotas mínimas de nominación a cargos de libre nombramiento y remoción, al igual que en los cargos de elección popular., entre otras. Asimismo, se efectúa un análisis sobre la participación de la mujer desde los territorios, efectuando un examen sobre el cumplimiento de la cuota legal de representación política de la mujer en cargos de representación popular. De igual manera, se realizan precisiones importantes de cara a la implementación del Acuerdo de Paz en lo que se refiere a garantías que promuevan la participación política de la mujer como medio de construcción de paz. Conclusiones: Se reafirma la necesidad de reivindicar los derechos políticos de la mujer que a través de los años han sido vulnerados y se incita a garantizar los diversos mecanismos democráticos con los que se cuenta para lograr la consecución de una paz estable y duradera.
Secondhand Smoke Exposure of Expectant Mothers in China: Factoring in the Role of Culture in Data Collection
Authors: Su Zhaohui , McDonnell Dean , Abbas Jaffar , Shi Lili , Cai Yuyang , Yang Ling
Published: October 2021

Cancer is the leading cause of death worldwide. Tobacco smoking, including secondhand smoking, causes cancer and is responsible for over 22% of global cancer deaths. The adverse impacts of secondhand smoke are more pronounced for expectant mothers, and can deteriorate both mothers’ and infants’ health and well-being. Research suggests that secondhand smoke significantly increases expectant mothers’ risk of miscarriage, cancer, and other chronic disease conditions, and exposes their unborn babies to an increased likelihood of having life-long poor health. In China, a pregnant woman’s family members, such as her husband, parents, or in-laws, are the most likely people to be smoking around her. Due to traditional Chinese cultural practices, even though some expectant mothers understand the harm of secondhand smoke, they may be reluctant to report their family members’ smoking behaviors. Resulting in severe underreporting, this compromises health experts’ ability to understand the severity of the issue. This paper proposes a novel approach to measure secondhand smoke exposure of pregnant women in the Chinese context. The proposed system could act as a stepping stone that inspires creative methods to help researchers more accurately measure secondhand smoking rates of expectant mothers in China. This, in turn, could help health experts better establish cancer control measures for expectant mothers and decrease their cancer risk.
Excess Mortality During the COVID-19 Pandemic in Jordan: Secondary Data Analysis (Preprint)
Authors: Khader Yousef , Al Nsour Mohannad
Published: October 2021

BACKGROUND

All-cause mortality and estimates of excess deaths are commonly used in different countries to estimate the burden of COVID-19 and assess its direct and indirect effects.

OBJECTIVE

This study aimed to analyze the excess mortality during the COVID-19 pandemic in Jordan in April-December 2020.

METHODS

Official data on deaths in Jordan for 2020 and previous years (2016-2019) were obtained from the Department of Civil Status. We contrasted mortality rates in 2020 with those in each year and the pooled period 2016-2020 using a standardized mortality ratio (SMR) measure. Expected deaths for 2020 were estimated by fitting the overdispersed Poisson generalized linear models to the monthly death counts for the period of 2016-2019.

RESULTS

Overall, a 21% increase in standardized mortality (SMR 1.21, 95% CI 1.19-1.22) occurred in April-December 2020 compared with the April-December months in the pooled period 2016-2019. The SMR was more pronounced for men than for women (SMR 1.26, 95% CI 1.24-1.29 vs SMR 1.12, 95% CI 1.10-1.14), and it was statistically significant for both genders (P<.05). Using overdispersed Poisson generalized linear models, the number of expected deaths in April-December 2020 was 12,845 (7957 for women and 4888 for men). The total number of excess deaths during this period was estimated at 4583 (95% CI 4451-4716), with higher excess deaths in men (3112, 95% CI 3003-3221) than in women (1503, 95% CI 1427-1579). Almost 83.66% of excess deaths were attributed to COVID-19 in the Ministry of Health database. The vast majority of excess deaths occurred in people aged 60 years or older.

CONCLUSIONS

The reported COVID-19 death counts underestimated mortality attributable to COVID-19. Excess deaths could reflect the increased deaths secondary to the pandemic and its containment measures. The majority of excess deaths occurred among old age groups. It is, therefore, important to maintain essential services for the elderly during pandemics.
A novel case-based reasoning system for breast cancer diagnosis: considering the effects of external characteristics of cases
Abstract (Preprint)
Authors: Gu Dongxiao , Zhao Wang , Yang Xuejie , Su Kaixiang , Liang Changyong , Zhang Gongrang , Zolotarev Oleg V.
Published: October 2021

BACKGROUND

Artificial intelligence can help physicians improve the accuracy of breast cancer diagnosis. However, the effectiveness of AI applications is limited by doctors’ adoption of the results recommended by the AI systems. A case-based reasoning system for breast cancer diagnosis (CBR-BCD) that considers the effects of external characteristics of cases (ECC) can not only provide doctors with more accurate results for auxiliary diagnosis, but also improve doctors’ trust in the results, so as to encourage doctors to adopt the results recommended by the system.

OBJECTIVE

The objective of our study is to develop a novel integrated case-based reasoning (CBR) framework based on Naive Bayes and K-Nearest Neighbor (KNN) algorithms considering the effects of external characteristics of cases (CBR-ECC) and a corresponding system named CBR-BCD to assist in diagnosis and promote adoption by doctors.

METHODS

We used a real-world data set from the Maputo Central Hospital in Mozambique and constructed the CBR-ECC model and corresponding CBR-BCD system. We performed data processing and obtained six internal features and three external features of the cases. We randomly divided the 1214 cases into a training group and a testing group. The performance of the model was evaluated by accuracy and the area under the receiver operating characteristic curve (AUC).

RESULTS

The system based on the CBR-ECC model was developed. In the first stage of this model, Naive Bayes showed the best performance, compared with KNN and J48 decision tree classifiers, with an accuracy rate of 95.87%. In the second stage, the accuracy of the KNN model with the optimal K value of 2 was 99.40%. In the third stage, after considering the external characteristics of the cases, the rankings of recommendation changed. Finally, we report the users’ evaluation of the novel CBR system in a real hospital scenario; we found that it is superior to the original system.

CONCLUSIONS

CBR-BCD not only enables accurate case recommendations to support health practitioners in diagnosing breast cancer and reducing diagnostic inaccuracies, but also facilitates the adoption of system-recommended results by physicians, which is valuable for clinicians to assist in diagnosis. It enables the early screening of breast cancer to improve the quality of breast cancer management and reduces the socioeconomic burden compared to traditional methods.
A Teleconsultation Device, Consult Station, for Remote Primary Care: Multisite Prospective Cohort Study (Preprint)
Authors: Falgarone Géraldine , Bousquet Guilhem , Wilmet Arnaud , Brizio Albert , Faure Valérie , Guillouet Celestin , Baudino Franck , Roque Isabelle , Mayol Samuel , Pamoukjian Frederic
Published: October 2021

BACKGROUND

Telemedicine technology is a growing field, especially in the context of the COVID-19 pandemic. Consult Station (Health for Development) is the first telemedicine device enabling completely remote medical consultations, including the concurrent collection of clinical parameters and videos.

OBJECTIVE

Our aim was to collect data on the multisite urban and suburban implementation of the Consult Station for primary care and assess its contribution to health care pathways in areas with a low density of medical services.

METHODS

In a proof-of-concept multisite prospective cohort study, 2134 consecutive patients had teleconsultations. Consultation characteristics were analyzed from both the patient and practitioner perspective.

RESULTS

In this study, the main users of Consult Station were younger women consulting for low-severity seasonal infections. Interestingly, hypertension, diabetes, and preventive medical consultations were almost absent, while they accounted for almost 50% of consultations with a general practitioner (GP). We showed that for all regions where the Consult Station was implemented, the number of consultations increased as GP density decreased. The study of practitioner characteristics showed GPs from metropolitan areas are motivated to work with this device remotely, with a high level of technology acceptability.

CONCLUSIONS

The multisite implementation of Consult Station booths is suitable for primary care and could also address the challenge of “medical deserts.” In addition, further studies should be performed to evaluate the possible contribution of Consult Station booths to limiting work absenteeism.
Trusted Data Spaces as a Viable and Sustainable Solution for Networks of Population-Based Patient Registries (Preprint)
Authors: Nicholson Nicholas , Caldeira Sandra , Furtado Artur , Nicholl Ciaran
Published: October 2021

UNSTRUCTURED

Harmonization and integration of health data remain as the focus of many ongoing efforts toward the goal of optimizing health and health care policies. Population-based patient registries constitute a critical element of these endeavors. Although their main function is monitoring and surveillance of a particular disease within a given population, they are also an important data source for epidemiology. Comparing indicators across national boundaries brings an extra dimension to the use of registry data, especially in regions where supranational initiatives are or could be coordinated to leverage good practices; this is particularly relevant for the European Union. However, strict data protection laws can unintentionally hamper the efforts of data harmonization to ensure the removal of statistical bias in the individual data sets, thereby compromising the integrated value of registries’ data. Consequently, there is the motivation for creating a new paradigm to ensure that registries can operate in an environment that is not unnecessarily restrictive and to allow accurate comparison of data to better ascertain the measures and practices that are most conducive to the public health of societies. The pan-European organizational model of cancer registries, owing to its long and successful establishment, was considered as a sound basis from which to proceed toward such a paradigm. However, it has certain drawbacks, particularly regarding governance, scalability, and resourcing, which are essential elements to consider for a generic patient registry model. These issues are addressed in a proposal of an adapted model that promises a valuable pan-European data resource for epidemiological research, while providing a closely regulated environment for the processing of pseudonymized patient summary data on a broader scale than has hitherto been possible.
TOXICOLOGICAL AND BEHAVIOR ANALYSES OF A FOLIOSE LICHEN PARMOTREMA TINCTORUM (DELISE EX NYL.) HALE EXTRACT USING ZEBRAFISH (DANIO RERIO) MODEL
Authors: SHENBAGAM MUTHU , MARIRAJ MURUGAN , KALIDOSS RAJENDRAN , ARUMUGAM DEEPA MACHAMPALAYAM , PONMURUGAN PONNUSAMY
Published: October 2021

Objective: The objective of the study was to evaluate the toxicity and behavior analysis with the extract of foliose lichen Parmotrema tinctorum against the adult zebrafish.
Methods: The zebrafishes were exposed to different concentrations of P. tinctorum extract such as 50, 100, and 200 mg/ml for 7 days of exposure, in which the mortality and behavioral responses of zebrafishes were recorded. The standard histopathological examination was conducted with the lichen extracts of P. tinctorum.
Results: The results revealed that P. tinctorum extract did not show any prominent behavior abnormalities in zebrafishes even at a high concentration of 200 mg/ml. The extract was found to have dose-dependent toxic to zebrafish and the number of neutrophil cells in the muscle bundles reduced at a high concentration. The results of the inflammatory marker gene expression using polymerase chain reaction results suggested that the dose-dependent suppression of tumor necrosis factor gene by the P. tinctorum lichen extract.
Conclusion: Overall, concluded that the extract might contain anti-inflammatory induction properties and further tests are required to prove apoptosis and anticancer activity using other in vivo or in vitro techniques.
A NEW C0 THIRD-ORDER SHEAR DEFORMATION THEORY FOR THE NONLINEAR FREE VIBRATION ANALYSIS OF STIFFENED FUNCTIONALLY GRADED PLATES
Authors: Ton-That Hoang Lan
Published: October 2021

Nonlinear free vibration of stiffened functionally graded plates is presented by using the finite element method based on the new C0 third-order shear deformation theory. The material properties are assumed to be graded in the thickness direction by a power-law distribution. Based on the Von Karman theory and the third-order shear deformation theory, the nonlinear governing equations of motion are derived from the Hamilton’s principle. An iterative procedure based on the Newton-Raphson method is employed in computing the natural frequencies and mode shape. The comparison between these solutions and the other available ones suggests that this procedure is characterized by accuracy and efficiency.
HAMILTONIAN-BASED FREQUENCY-AMPLITUDE FORMULATION FOR NONLINEAR OSCILLATORS
Authors: He Ji-Huan , Hou Wei-Fan , Qie Na , Gepreel Khaled A. , Shirazi Ali Heidari , Sedighi Hamid Mohammad-
Published: October 2021

Complex mechanical systems usually include nonlinear interactions between their components which can be modeled by nonlinear equations describing the sophisticated motion of the system. In order to interpret the nonlinear dynamics of these systems, it is necessary to compute more precisely their nonlinear frequencies. The nonlinear vibration process of a conservative oscillator always follows the law of energy conservation. A variational formulation is constructed and its Hamiltonian invariant is obtained. This paper suggests a Hamiltonian-based formulation to quickly determine the frequency property of the nonlinear oscillator. An example is given to explicate the solution process.
Bishop Andrey (worldly Aleksandr Ukhtomskiy) — founder of the journal “Employee of Transcaucasian Mission”
Authors:   Autonomous Non-profit Organisation “Book Club of the Writers’ Union”, Sterlikova Sofiyanina A.
Published: October 2021

The article provides a brief overview of the history of the Sukhum diocese, as well as provides more detailed information about Bishop Andrey (worldly Aleksandr Ukhtomskiy), who occupied the Sukhumi Eparchy in 1911–1913. An outstanding undertaking by Bp. Andrey was the establishment of the Church-missionary journal “Employee of the Transcaucasian Mission”, which published sermons, articles of religious-moral, church-historical, ethnographic content, discussed issues of missionary affairs, church-social and church-school. One of the main problems of Sukhumi eparchy was the paganism of the population; in each issue of the “Employee” this issue was considered from different angles. Covering the life of parishes, the publication posted on its pages information about parish churches, their history and condition; these testimonies are gaining undoubted value today. It is a reliable picture of the life of Abkhazia in the first decades of the 20th century created by statistical data published in the “Employee” — on the number of births, married and buried parishioners, on the composition of the population and religion. The journal also published the so-called “Travel Notes” that told about the travels of clergymen to remote corners of Abkhazia to communicate with local residents. Some of the publications of the materials of the journal “Employee of the Transcaucasian Mission” are offered to the readers’ attention.
Titularidade da memória: breves notações acerca das contribuições de Maurice Halbwachs e Paul Ricoeur
Authors: Oliveira Santos Marisa
Published: October 2021

A memória, enquanto objeto de investigação dentro do campo científico, faz emergir inúmeras discussões, ao tempo que assume seu papel social de resguardar informações e experiências, evocar o passado e acervar o vivido. O presente estudo tem como objetivo central discutir, em breves considerações, a titularidade da memória, reconhecida em dois campos: o individual e o coletivo. A princípio, far-se-á uma sucinta teorização acerca da memória, bem como apresentar-se-á a maneira como alguns autores a compreendem em seus respectivos campos de estudo. Vencida essa parte introdutória, sequencialmente, abre-se a discussão em torno de duas abordagens, cujas propriedades são bem específicas, para verificar similitude entre ambas. A primeira, de Maurice Halbwachs (2006); a segunda, de Paul Ricoeur (2007). Após o estudo bibliográfico proposto, verificou-se que as ideias desses dois expoentes convergem para uma direção muito próxima daquilo que se buscou defender a respeito da memória no seu campo coletivo: o entendimento de que, no seu entorno, o indivíduo está sempre vinculado a pessoas que, direta ou indiretamente, o ajudam a evocar suas lembranças em razão das experiências do que fora vivido, seja o coletivo um grupo, os outros, sejam os próximos.
Modernização agrícola e produção de grãos: um estudo sobre o potencial de contaminação do solo por defensivos agrícolas na região Oeste da Bahia.
Authors: De Jesus Santos Edilene
Published: October 2021

Este trabalho tem por objetivo analisar o potencial de contaminação do solo pelo uso de defensivos agrícolas na produção de grãos da região Oeste da Bahia. Para tanto, realizou-se o cálculo do Índice de Potencial de Contaminação pelo uso de Defensivos Agrícolas – IDEF para os municípios de Barreiras-BA, São Desidério-BA, Formosa do Rio Preto-BA e Luís Eduardo Magalhães-BA, abrangendo as culturas do milho, da soja, do algodão e do feijão. O estudo parte do entendimento de que é inevitável a expansão da produção de grãos na região Oeste sem comprometer o solo pelo uso de defensivos agrícolas. A partir dessa compreensão, a hipótese básica é de que a necessidade de expandir a produção para atender a demanda de mercado a longo prazo, levará os produtores a aumentarem a produção e a produtividade, e, como consequência, um maior consumo de defensivos agrícolas. Os resultados obtidos sugerem que a soja foi a cultura que apresentou IDEF com valor de 0,20 e a cultura do feijão o menor índice, com valor médio de 0,99. Conclui-se que o aumento da produção para atender a demanda crescente do mercado internacional e nacional, principalmente da soja, resulta num maior consumo de defensivos e, consequentemente, em um maior potencial de contaminação do solo para a região Oeste da Bahia.
Análise da distribuição da riqueza gerada por meio da Demonstração do Valor Adicionado
Authors: Antonio Marcelino José , Dos Santos Danielle , V. C. Gouveia Gustavo
Published: October 2021

Este estudo analisa, por meio da Demonstração do Valor Adicionado (DVA), a formação da riqueza gerada de duas empresas do setor de água e saneamento listadas na B3 (Brasil, Bolsa, Balcão), a Sabesp, de economia mista, e a Iguá, de economia privada, no período de 2013 a 2018. A pesquisa caracteriza-se como qualitativa e quantitativa e o método utilizado foi o estudo de caso, com análise documental, de natureza descritiva. Conforme os resultados, tanto a Sabesp quanto a Iguá possuem quase os mesmos valores com relação à distribuição de riqueza entre empregados e governo. Nos índices de participação de terceiros, a empresa Iguá possui números maiores, ao passo que, na participação dos acionistas, a Sabesp é que sobressai. Com relação aos agentes privados, a Sabesp distribui mais para terceiros, enquanto a Iguá faz uma maior distribuição para os acionistas.
Impactos socioambientais nas construções de barragens hidrelétricas
Authors: Renata Freitas Fontes Alessandra , Severo Giudice Dante
Published: October 2021

O presente artigo possui como objetivo geral definir e traçar análise sob a implantação de barragens hidrelétricas no Brasil. O estudo sobre os impactos causados por tais construções é realizado por intermédio do prisma econômico, social e ambiental. Para o estudo, parte-se da vertente jurídico-sociológica e utiliza-se a metodologia de pesquisa teórica, a  partir de uma revisão bibliográfica pautada em documentos que evidenciam o tema exposto. Como resultado da pesquisa, infere-se que existe na construção de tais empreendimentos uma assimetria de poder, que origina uma apropriação social sobre os conflitos socioambientais, na medida em que a utilização dos espaços ambientais ocorre em detrimento do uso que outros segmentos sociais fazem do território. Dessa maneira, constata-se que barragens hidrelétricas são geradoras de injustiça ambiental, visto que são construídas e implementadas com a finalidade precípua de beneficiar determinados setores econômicos, em prol de direitos fundamentais da comunidade direta e indiretamente afetada.
Sustentabilidade da investigação em educação: da concepção à implementação de um referencial
Authors: Guerra Cecília
Published: October 2021

Este artigo pretende apresentar um recorte do processo metodológico referente ao desenvolvimento de um referencial para a promoção da sustentabilidade de investigação em educação. Este produto decorre de um estudo de investigação e desenvolvimento (I&D), envolvendo a colaboração com diversos agentes-chave do ensino superior português (investigadores e docentes universitários) no desenho, implementação e avaliação da qualidade de estratégias e instrumentos promotoras da sustentabilidade de inovações educativas resultantes da investigação. Os dados foram recolhidos através da aplicação de questionários, realização de entrevistas e observação participante da investigadora do projeto. A análise de conteúdo dos documentos produzidos pelos participantes (ex. artigos científicos produzidos) e a análise dos registos de observação do trabalho desenvolvido na rede (observação participante da investigadora do estudo) é um processo contínuo, com ciclos de reflexão-ação para ajudar a identificar as potencialidades, constrangimentos e definir melhorias para produzir a segunda versão do referencial. Pretende-se, por fim, informar (e direcionar) a sustentabilidade de inovações educativas desenvolvidas a partir de investigação educacional financiada.
A OBRA DE PAULO FREIRE SOB A PERSPECTIVA DO MOVIMENTO ESCOLA SEM PARTIDO
Authors: Silva Mauro Sérgio Santos da
Published: October 2021

O presente texto discorre acerca da visão que o Movimento Escola Sem Partido (MESP) propaga da obra de Paulo Freire. Propõe, mediante a análise de suas publicações em redes sociais, que o MESP apresenta uma compreensão imprecisa sobre o pensamento de Freire, realizando uma associação inadequada entre suas ideias e o marxismo, pressupondo, sem base científica robusta ou elementos comprobatórios consistentes, que a educação brasileira encontra-se dominada por um ideário de esquerda marxista-gramsciano, consequência de um processo de doutrinação política empreendido nas escolas, metodologicamente orientado pelo trabalho de Freire, fato que estaria entre as razões de seu insucesso. Propomos que a obra do pensador pernambucano personifica, sob a perspectiva do MESP, um conjunto de transformações na educação brasileira às quais o referido Movimento se opõe e reage, o que nos permite classificá-lo como reacionário.
DIALOGICIDADE EM TEMPOS DIGITAIS: O LEGADO DE PAULO FREIRE À CONSTITUIÇÃO DA PRÁXIS DOCENTE (RE)EXISTENTE
Authors: Tomelin Nilton Bruno , Rausch Rita Buzzi
Published: October 2021

A presente investigação buscou identificar o legado de Paulo Freire à constituição da práxis docente (re)existente diante da inserção das mídias na educação em uma perspectiva dialógica. Realizou-se uma pesquisa teórica, direcionada às obras de Paulo Freire sobre o tema. Partindo da dialogicidade e da criticidade, estabelece relações que podem ser potencializadas pela mídia e propõe uma reflexão política acerca do seu protagonismo na educação dialógica, considerando suas intencionalidades. Salienta-se que a inserção das mídias na práxis docente não ofusca a presença do professor no processo, mas o potencializa sinalizando para uma nova forma de nele existir. O texto aponta contribuições de Freire para uma educação dialógica permeada pelas mídias para o século XXI. Desafia para novas percepções de educação, escola, professor, politicidade, mídias, e alerta sobre o protagonismo estudantil e a rigorosidade nos espaços escolares, além da necessidade de (re)existir por meio da consolidação do diálogo, como princípio fundante da práxis docente.
A ATUALIDADE DO PENSAMENTO FREIREANO: UMA PONTE DIALÓGICA COM A LINGUÍSTICA APLICADA
Authors: Lima Ana Maria Oliveira , Souza Ester Maria de Figueiredo
Published: October 2021

O artigo enfoca ideias freireanas, cotejando as noções de linguagem e identidade, temas que são referenciados na obra freireana e na Linguística Aplicada. Debruça-se sobre aspectos sociológicos, educacionais e referentes à linguagem, o que nos apontam caminhos para uma abordagem dialógica com a Linguística Aplicada Crítica, pelo viés transdisciplinar. A transdisciplinaridade é mobilizada, neste estudo, pela ligação entre as áreas de conhecimento que possuem objetos específicos, mas que revelam a necessidade de compor uma rede de para interpretar o fazer ético da pesquisa. Desta forma, contribuímos com a discussão a respeito da atualidade do pensamento freireano, em constante busca pela sua assunção no e para mundo. O percurso metodológico é de natureza bibliográfica, apresentando a pedagogia freireana articulada com a Linguística Aplicada, sob a perspectiva da linguagem, do diálogo e das identidades – inquietações surgidas durante pesquisa de mestrado. Conclui-se que, na contemporaneidade, a pedagogia freireana, cotejada com a Linguística Aplicada, atualiza-se na reafirmação do ato de educar como um agir ético e, por consequência, na emancipação do ser humano como postulado por Freire e pela Linguística Aplicada.
CARACTERÍSTICAS E DESAFIOS DOS/NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL: VOZES DE ESTAGIÁRIOS
Authors: Ferreira Lúcia Gracia , Abreu Roberta Melo de Andrade
Published: October 2021

Os Anos Iniciais do Ensino Fundamental se constituem como um campo complexo, permeado por múltiplas relações, dilemas, contradições e especificidades. Neste trabalho, objetivamos caracterizar essa etapa de escolarização refletindo sobre alguns desafios do processo de aprender a ensinar na perspectiva dos estudantes no componente curricular de Estágio Supervisionado nos Anos Iniciais do curso de Pedagogia da Universidade Federal do Recôncavo da Bahia. A abordagem qualitativa de pesquisa desenha a trilha metodológica desse trabalho, que se configura também como exploratório. Os dados foram construídos no âmbito do referido componente curricular, ministrado no segundo semestre letivo do ano de 2020, remotamente, a partir de uma atividade que envolvia a resolução de seis situações-problemas pelos estagiários, e analisados a partir da técnica da análise de conteúdo. Os resultados evidenciaram o desafio de alfabetizar como um dos que ecoam nas vozes dos alunos e outros como dominar várias áreas de conhecimento, realizar o ensino interdisciplinar, planejar, realizar o fazer docente em meio a condições de ausências organizacionais, materiais, de estrutura física, de formação, de conhecimentos e de autonomia. Desse modo, compreendemos que os estagiários apreenderem bem os desafios da docência dos anos iniciais, ao destacarem aspectos que compõe o cotidiano escolar e profissional do professor.
Esquistossomose mansônica: uma análise do perfil epidemiológico na região sudeste
Authors: Barreto Costa João Victor , Marques da Silva Filho José
Published: October 2021

Este estudo tem o objetivo de traçar o perfil epidemiológico da esquistossomose mansônica (EM) na região Sudeste do Brasil entre os anos de 2013 a 2017. É um tipo de estudo descritivo de tendência temporal, em que foram utilizados dados disponíveis nos registros de notificação do Departamento de Informática do Sistema Único de Saúde (DATASUS), considerando o período de 2013 a 2017. O cálculo da incidência foi obtido através da estimativa populacional projetada pelo Instituto Brasileiro de Geografia e Estatística - IBGE. Os dados coletados foram processados pelo Excel 2016. Durante o período foram notificados 21.464 casos da doença no Sudeste brasileiro, tendo Minas Gerais (73,25%) e São Paulo (15,52%) os maiores valores absolutos de contaminação. Percebe-se que a incidência na região diminuiu de 6,03 para 3,35 casos/ano. A maior frequência dos casos envolveu os adultos que estão entre a faixa etária dos 20 aos 39 anos, sendo o sexo masculino (35,5%) o mais acometido. Além disso, a EM teve uma maior predominância na zona urbana (72,7%). Assim, os casos notificados e a  incidência da doença diminuíram na região estudada. Conclui-se que estratégias preventivas e educacionais necessitam ser adotadas, com o intuito de reduzir a incidência de EM na área endêmica da região Sudeste.
Análise do programa de melhoria do acesso e da qualidade da atenção básica (pmaq) da equipe de saúde da família (esf)
Authors: Lima Natali Ramos , Gomes Liane Oliveira Souza
Published: October 2021

Objetivou-se analisar os indicadores de desempenho do Programa de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ), no processo de trabalho da Equipe de Saúde da Família (ESF), nas áreas estratégicas saúde da mulher e da criança, em um município baiano. Pesquisa quantitativa, com auxílio do Excel 2013. Os indicadores apresentaram resultados insatisfatórios quando comparados os dados avaliados das ESF no processo de trabalho em relação ao preconizado pela política da Atenção Básica. Constatou-se a importância desses indicadores na avaliação do processo de trabalho das equipes e que algumas dificuldades, interferem na qualidade da assistência e, consequentemente, na melhoria desses indicadores.
Impacts of environmental stress on the resistance and resilience of algal-associated bacterial communities
Authors: Morrissey Kathryn , Iveša Ljiljana , Delva Soria , D'Hondt Sofie , Willems Anne , Clerck Olivier De
Published: October 2021

Algal associated bacteria are fundamental to the ecological success of
green macroalgae such as Caulerpa. The resistance and resilience of
algal-associated microbiota to environmental stress can promote algal
health and genetic adaptation to changing environments. The composition
of bacterial communities has been shown to be unique to algal
morphological niches. Therefore, the level of response to various
environmental perturbations may in fact be different for each
niche-specific community. In situ experiments were set up to investigate
the effect of nutrient enrichment and temperature stress on the
bacterial communities associated with Caulerpa cylindracea. Bacteria
associated with separate morphological niches along the thallus were
characterised using the 16S rRNA gene and community similarities were
compared. Resistance and resilience were calculated to further
understand the initial changes and recovery of microbial composition in
response to different abiotic stresses. The results of this study
provide evidence that nutrient enrichment has a significant influence on
the taxonomic and functional structure of the epimirocbiota. Temperature
stress had a significant effect on the rhizomicrobiota taxonomic
composition, with the combined stress potentially having additive
effects on the functional performance of the rhizomicrobiota over time.
This further contributes to our understanding of algal microbiome
dynamics in response to environmental changes.
General Lyapunov-Based Iterative Algorithm for Linear Quadratic Regulator Problem of Stochastic Systems with Markovian Jump
Authors: Liu Meijun , Zhao Xueyan , Deng feiqi
Published: October 2021

This paper investigates the linear quadratic regulator(LQR) problem of
linear stochastic systems with Markovian jump. Firstly, two iterative
algorithms are proposed for solving the corresponding coupled algebraic
Riccati equa- tions (CAREs) based on the general-type Lyapunov equation
derived from linear stochastic systems. It is verified that the second
algorithm adding an adjustable factor converges faster than the first
one without it. Secondly, a monotonic convergence theorem is established
for the proposed iterative algorithms under certain initial conditions.
In the end, a numerical example is given to verify the efficiency of the
proposed algorithms.
Computational Analysis of Biophilic Scale Distributions of Façades in Kaunas City Centre
Authors: Ivaskevicius Marius , Dogan Huriye Armagan
Published: October 2021

The results of numerous studies which are performed on the concepts of Biophilic architecture demonstrate that it can influence emotional tension and health of the observers. Moreover Biophilic research exhibits that not only natural plants induce biophilic response, but also artificial, human creations with certain fractal dimensions or distributions of scales can have an impact. In that regard, the aim of this research is to describe the relation between measurable Biophilic properties of façades and the emotional tension inducing health problems measured with the count of medical emergency arrivals in the vicinity of the façades. To achieve the aim several tasks were completed, such as the development of a methodology of façade analysis, and application of it in an experiment to test the validity. The engineered features found by this research are based on statistical analysis of distributions of line lengths and distances between lines in a drawing of a façade. To test the methodology, a linear regression model with six features was trained and it achieved a 37 % confidence, measured with R² adjusted, predicting the number of medical emergency arrivals. Simplicity of the model allowed to make additional insights into the specificity of façade properties, and their importance to Biophilia, which establishes the scientific novelty and the significance of this research.
A large-scale study on the effectiveness of a Bacillus subtilis Ch-13-based biofungicide against green mould disease and mushroom yield improvement
Authors: Potocnik Ivana , Todorovic Biljana , Milijasevic-Marcic Svetlana , Lukovic Jelena , Kanizai-Saric Gabriella , Majic Ivana , Rekanovic Emil
Published: October 2021

The aim of this study was to test a biofungicide based on Bacillus subtilis
Ch-13 and its effectiveness in the control of green mould disease of
cultivated mushroom in comparison with the fungicide prochloraz.
Biofungicide effectiveness in disease control and impact on yield were
evaluated on Agaricus bisporus after its natural infection with Trichoderma
aggressivum in a commercial mushroom growing facility. An assay for testing
the microbial efficacy of the biofungicide was conducted in two different
procedures involving either three or two split doses. The highest
statistically significant effectiveness in green mould control was shown by
the fungicide prochloraz (71.43%), followed by the biofungicide applied in
tree split doses (53.57%), and finally its two doses (45.46%). The
biofungicide significantly improved yield in comparison with an untreated
control and the fungicide prochloraz. Three split applications of B.
subtilis strain Ch-13 enhanced mushroom yield to a larger extent than its
two split doses, although the same final amount was used in both procedures.
Biofungicide application in three split doses increased the total mass of
harvested mushrooms 8.41% compared to the untreated control, and 10.53%
compared to the fungicide prochloraz. These results implied that the
biofungicide should be applied in three split applications: 30 ml (second
day after casing) + 15 ml (two weeks after casing) + 15 ml (after first
flush, 20-25 days after casing). The biofungicide B. subtilis Ch-13 should
be further investigated regarding its joint usage with chemical fungicides
in different application procedures, as it showed remarkable characteristics
both in terms of promoting mushroom yield and inhibiting the spread of
mycopathogenic T. aggressivum.
Different Effects of Lifestyle Intervention in High- and Low-Risk Prediabetes
Authors: Fritsche Andreas , Wagner Robert , Heni Martin , Kantartzis Kostantinos , Machann Jürgen , Schick Fritz , Lehmann Rainer , Peter Andreas , Dannecker Corinna , Fritsche Louise , Valenta Vera , Schick Renate , Nawroth Peter Paul , Kopf Stefan , Pfeiffer Andreas FH , Kabisch Stefan , Dambeck Ulrike , Stumvoll Michael , Blüher Matthias , Birkenfeld Andreas L , Schwarz Peter , Hauner Hans , Clavel Julia , Seißler Jochen , Lechner Andreas , Müssig Karsten , Weber Katharina , Laxy Michael , Bornstein Stefan , Schürmann Annette , Roden Michael , Angelis Martin Hrabe de , Stefan Norbert , Häring Hans-Ulrich
Published: October 2021

Lifestyle
intervention (LI) can prevent type 2 diabetes, but response to LI varies depending
on risk subphenotypes. We tested if prediabetic individuals with low risk
benefit from conventional LI and individuals with high risk benefit from an
intensification of LI in a multi-center randomized controlled intervention over
12 months with 2 years follow up. 1105 prediabetic individuals
based on ADA glucose criteria were stratified into a high- and low-risk
phenotype, based on previously described thresholds of insulin secretion,
insulin sensitivity and liver fat content. Low-risk individuals were randomly
assigned to conventional LI according to the DPP protocol or control (1:1),
high-risk individuals to conventional or intensified LI with doubling of
required exercise (1:1). A total of 908 (82%) participants completed the study. In high-risk individuals,
the difference between conventional and intensified LI in post-challenge
glucose change was -0.29 mmol/l [CI:-0.54;-0.04], p=0.025. Liver fat (-1.34 percentage points [CI:-2.17;-0.50], p=0.002) and
cardiovascular risk (-1.82[CI:-3.13-0.50],p=0.007) underwent larger reductions
with intensified than with conventional LI. During a follow up of 3 years,
intensified compared to conventional LI had a higher probability to normalize
glucose tolerance (p=0.008). In conclusion, it is possible in high-risk
individuals with prediabetes to improve glycemic and cardiometabolic outcomes
by intensification of LI. Individualized, risk-phenotype-based LI may be beneficial
for the prevention of diabetes.
Group Membership or Identity?
Authors: Teschl Miriam
Published: October 2021

As part of an article symposium on Partha Dasgupta and Sanjeev Goyal’s “Narrow Identities” (2019, Journal of Institutional and Theoretical Economics), Miriam Teschl reflects on the distinctive concept of identity liberal cosmopolitans have and how it may or may not be captured in economic models of identity choice.
1st Kyiv Round Table Dedicated to TMJ Fractures Treatment (1st Kyiv TMJ Round Table): 27, 28 December 2018 – Kyiv – Ukraine
Authors: Pavlenko Ruslan , Romanova Anna , Fesenko Ievgen
Published: October 2021

1st Kyiv Round Table (RT) dedicated to temporomandibular joint (TMJ) fractures treatment was extremely successful. And it`s symbolic that initiative of Professor Kopchak, Associate Professor Chepurnii, and Professor Ankin to establish TMJ RT was supported by the world titan in the diagnostics and treatment of TMJ fractures–Dr. Andreas Neff (Marburg, Germany).
Andreas Neff, MD, DMD, PhD, FEBOMS, Univ. Prof. is a Head and Chairman in the Department of Oral and Craniomaxillofacial Surgery, Oral Surgery and Implantology UKGM GmbH, University Hospital of Marburg & Medical Faculty, Philipps University Marburg [1].