bluuebunny/crossref_metadata_2025 huggingface dataset:
AUTOMATIC TESTING WITH BLACK BOX TESTING METHODS AND BOUNDARY VALUE ANALYSIS TECHNIQUES AT PT. HARTONO ISTANA TEKNOLOGI
Authors: Kurniawan Andreas Edwin , Herawati Rosita
Published: August 2024

This study aims to direct the testing pattern from manual testing to automated testing. Another goal is that the use of manual methods is less effective, efficient, time consuming, expensive and allows for human testing errors. With automated testing, this problem can be solved. Before performing automated testing, must create a test case. Test cases are made using the Boundary Value Analysis (BVA) technique, the boundary value analysis technique is made by determining the upper and lower limits on a data. Automated testing using the selenium tool and the programming language used is python. After performing automated tests using the black box method, boundary value analysis technique, and selenium tools, we got the results. Testing is carried out on the company code menu, site, and location, testing is carried out as many as (180x). The results obtained after testing are kode perusahaan menu and nama perusahaan fields, the success rate is 50% fail and 50%. Next, in the kode perusahaan menu and nama perusahaan fields, the success rate is 25% fail and 75% success. Then, in the site menu and site fields, the success rate is 50% fail and 50% success. In the site menu and kode pos fields, the success rate is 25% fail and 75%. In the lokasi menu and tipe lokasi fields, the success rate is 25% fail and 75%. In the lokasi menu and kode fields, the success rate is 25% fail and 75% success.
TINJAUAN HUKUM ISLAM TERHADAP PRAKTIK JUAL BELI TANAH DI BAWAH TANGAN DI DESA TAMADAMPENG KECAMATAN GALESONG KABUPATEN TAKALAR
Authors: Risdayanti  , Sohrah  , Andi Intan Cahyani
Published: August 2024

Abstrak
Tanah sebagai tempat kita berpijak dan menopang sebagian besar kehidupan kita. Dalam praktiknya jual beli tanah tidak selamanya dapat berjalan dengan lancar jual beli tanah di bawah tangan di ddesa tamadampeng kecamatan galesong kabupaten takalar yang di mana penjual dan pembeli ini melakukan transaksi bukan di depan notaris/ppat, tak berupa surat di bawah tangan ini menimbulkan masalah di kemudian hari. Rumusan masalah dalam yaitu : bagaimana proses pelaksanaan jual beli tanah di bawah tangan yang terjadi didesa tamadampeng , kecamatan galesong, kabupaten takalar dan bagaimana pandangan hukum islam terhadap jual beli tanah di bawah tangan di desa tamadampeng, kecamatan galesong, kabupaten takalar. Penelitian ini bersifat tinjauan lapangan (field research) dan menggunakan metode penelitian observasi, wawancara, dokumentasi. Jual beli tanah di bawah tangan di desa tamadampeng, kecamatan galesong kabupaten takalar hukumnya tidak sah tidak memenuhi syarat, rukun jual beli dan banyak yang di rugikan di kemudian hari karna tidak melibatkan notaris dalam transaksi yang di lakukan di mana hanya selembar kwitansi yang bukan akta outentik yang hanya berdasar atas kepercayaan dan prosesnya tidak di lanjut ke badan pertanahan menurut masyarakat cukup keberatan karena biayanya yang relatif tinggi dan memakan waktu yang banyak untuk mengurusnya dan di hadapan kepala desa sudah cukup.
Kata Kunci: Di bawah Tangan, Hukum Islam, Jual Beli.
 
Abstract
Land as a place where we stand and sustains most of our lives. In practice, buying and selling land does not always run smoothly. Buying and selling land under the hands in Tamadampeng village, Galesong sub-district, Takalar district, where the seller and buyer do the transaction is not in front of a notary/ppat, not in the form of underhanded letters. This creates problems in later. The formulation of the internal problem is: what is the process of carrying out the sale and purchase of land under the hands that took place in Tamadampeng village, Galesong sub-district, Takalar district and what is the view of Islamic law on buying and selling land under the hands in Tamadampeng village, Galesong sub-district, Takalar district. This research is a field research (field research) and uses observation research methods, interviews, documentation. Buying and selling land privately in Tamadampeng village, Galesong sub-district, Takalar district, is illegal, does not meet the requirements, the pillars of sale and purchase and many losers in the future because they do not involve a notary in the transaction carried out where only a receipt is not an authentic deed which is only based on trust and the process is not forwarded to the land agency according to the community is quite objectionable because the costs are relatively high and it takes a lot of time to arrange it and it is sufficient in the presence of the village head.
Keywords: Under Hand, Islamic Law, Buying and Selling.
Organizational Justice and Employee Cynicism: Can Trust Mediate?
Authors: Khan Ryan Basith Fasih , Firmansyah Bagas Adi
Published: August 2024

This study examines how employee cynicism, characterized by negativity, skepticism, and distrust, can hinder productivity and organizational success. To understand this phenomenon in public organizations, we surveyed 163 public servants in East Java, Indonesia. We analyzed the data across different organizational sizes, performance levels, and strategic goals using an exploratory-based structural-equation model. Our findings reveal three key points. First, employees experience less cynicism when they perceive fairness, equality, and transparency in the workplace, highlighting the importance of organizational justice. Second, employee trust acts as a protective factor, further reducing cynicism. Finally, employee trust mediates the relationship between organizational justice and cynicism, suggesting that fostering trust strengthens the link between fair treatment and positive employee attitudes. These results emphasize the importance of staff departments and leadership promoting both organizational fairness and trust to create a healthier and more productive work environment.
Strategies of Islamic Religious Education Teachers in Guiding Prayer Practices in Darussalam Integrated Islamic Elementary School
Authors: Hariadi Hariadi , Zainuddin Fauziah , Mustaming Mustaming
Published: August 2024

This article discusses the Strategy of Islamic Religious Education Teachers in Guiding Prayer Practices in Darussalam Integrated Islamic Elementary Schools. The main topics of discussion in this study are: How is the implementation of coaching the practice of prayer to students at the Darussalam Integrated Islamic Elementary School? How is Islamic Religious Education teachers' strategy in fostering prayer practice at the Darussalam Integrated Islamic Elementary School in Palopo City? How are the obstacles and solutions given by the Religious Education teacher Islam in fostering the practice of prayer at the Darussalam Integrated Islamic Elementary School, Palopo City? This study aims to: determine the implementation of coaching students' prayer practice; knowing the strategy of Islamic Religious Education teachers in fostering students' prayer practice; knowing the obstacles and solutions for Islamic Religious Education teachers in fostering the practice of prayer at the Darussalam Integrated Islamic Elementary School, Palopo City. This research is descriptive qualitative research that uses a pedagogical and psychological approach. The author uses data collection techniques, among others, by making direct observations at the author's research location, interviewing Islamic Religious Education teachers, staff, and students, making documentation and collecting school documents, data analysis, data reduction, triangulation techniques, and presenting data and drawing a conclusion. The results of this study indicate that the development of the practice of prayer for students at the Darussalam Integrated Islamic Elementary School in Palopo City runs as much as possible by using the strategy of Islamic Religious Education teachers, namely by providing prayer guidance materials through the provision of materials and direct practice as well as students and teachers correcting reading errors and the student prayer movement, the obstacle faced by Islamic Religious Education teachers is the lack of parental supervision of students in participating in the current face-to-face learning program. The solution is to provide controlled learning both from school and from home to students by collaborating with parents of students and carrying out very strict health protocols.
PENGGUNAAN MEDIA BAHAN ALAM UNTUK MENINGKATKAN KEMAMPUAN KOGNITIF PESERTA DIDIK PADA RA RAODHATUL HIDAYAH KOTA PALOPO
Authors: Sri Maharani Ilyas  , Lisa Aditya Dwiwansyah Musa  , Suharni  , Ruhani
Published: August 2024

Penelitian ini mengkaji efektivitas penggunaan media bahan alam dalam meningkatkan kemampuan kognitif peserta didik, khususnya dalam mengenal angka, di RA Raodhatul Hidayah Kota Palopo. Menggunakan metode Penelitian Tindakan Kelas (PTK), studi ini melibatkan observasi dan dokumentasi sebagai teknik pengumpulan data. Analisis data dilakukan melalui reduksi, penyajian, dan penarikan kesimpulan. Hasil penelitian menunjukkan peningkatan signifikan dalam kemampuan mengenal angka. Pada pra-tindakan, rata-rata kemampuan anak adalah 6,5 (24%). Setelah intervensi, terjadi peningkatan pada Siklus I menjadi 7,8 (29%), dan lebih lanjut pada Siklus II mencapai 13,0 (48%). Temuan ini mengonfirmasi hipotesis bahwa penggunaan media bahan alam efektif dalam meningkatkan kemampuan kognitif peserta didik. Peningkatan sebesar 24% dari pra-tindakan hingga Siklus II menunjukkan dampak positif dari intervensi yang dilakukan.Penelitian ini memberikan wawasan berharga tentang potensi media bahan alam dalam pembelajaran anak usia dini. Hasil yang diperoleh dapat menjadi pertimbangan bagi pendidik dan pemangku kebijakan dalam mengembangkan strategi pembelajaran yang lebih efektif, khususnya dalam meningkatkan kemampuan kognitif anak usia dini.
DESAIN INTERIOR PENDIDIKAN ANAK USIA DINI DI RA AR-RAUDAH
Authors: Fatna Nur Sholikhah  , Rifngatul Faizah  , Hidayatu Munawaroh
Published: August 2024

Desain interior merupakan aspek krusial dalam menciptakan lingkungan yang fungsional, nyaman, dan estetis. Dalam konteks pendidikan anak usia dini, desain interior memainkan peran vital dalam membentuk lingkungan belajar yang mendukung perkembangan holistik anak-anak. Penelitian ini berfokus pada evaluasi komprehensif terhadap desain ruang di RA Arraudah, sebuah lembaga pendidikan anak usia dini. Hasil analisis menunjukkan bahwa desain interior di institusi tersebut masih jauh dari standar optimal dan menghadapi berbagai kendala signifikan. Akar permasalahan ini terletak pada kurangnya pemahaman yang mendalam di kalangan tenaga pendidik dan pimpinan sekolah mengenai urgensi desain interior yang sesuai untuk anak-anak usia dini. Pentingnya desain interior yang efektif dalam menciptakan lingkungan belajar yang mendukung perkembangan anak tidak bisa diabaikan. Oleh karena itu, upaya peningkatan pemahaman tentang prinsip-prinsip desain interior di RA Arraudah menjadi langkah yang sangat krusial. Perbaikan desain interior harus dilakukan secara holistik, melibatkan serangkaian pelatihan dan program pendidikan bagi staf pengajar. Melalui inisiatif ini, diharapkan para pendidik dapat memahami dan mengimplementasikan prinsip-prinsip desain yang selaras dengan kebutuhan perkembangan anak-anak. Implementasi desain interior yang tepat tidak hanya akan meningkatkan kualitas lingkungan fisik sekolah, tetapi juga berpotensi memberikan dampak positif pada proses pembelajaran dan perkembangan anak secara keseluruhan.
Surf pool and urban development in Madrid: A social analysis of sports tourism infrastructure
Authors: González Diego Santos
Published: August 2024

This study explores the impacts of introducing a surf pool in Madrid, Spain, on urban development, community dynamics, and local surfing culture. Through a qualitative methodology comprising in-depth interviews with local and non-local surfers, as well as a discussion group with residents of the neighborhood where the wave pool is being developed, we delve into the anticipated social, economic, and environmental implications of this innovative sports infrastructure. Our findings reveal a general optimism about the wave pool's potential to foster community engagement, enhance urban livability, and attract a vibrant, active population. However, concerns regarding potential gentrification effects and the sustainability of the project are also identified. This research contributes to the broader discourse on the integration of sports facilities into urban environments, highlighting the need for inclusive planning processes and sustainable development practices. The introduction of the wave pool in Madrid presents a unique case study in the interplay between urban sports infrastructure and city life, offering valuable insights for urban policymakers, planners, and the academic community. As cities continue to seek innovative ways to enhance urban environments and community well-being, the role of sports infrastructure, exemplified by the wave pool, emerges as a significant area of interest and investigation.
Domain-Specific FPGA-Based Digital Acquisition System for Hardware Accelerators Integration
Authors: Popovici Cosmin-Andrei , Stan Andrei , Manta Vasile-Ion
Published: August 2024

Domains like IoT (Internet of Things), ADAS (Advanced Driver Assistance System), Smart Homes and Smart Cities and XaaS (Everything-as-a-Service) put a great pressure in the last fifteen years on computer engineers for designing processors capable of higher precision computations performed in shorter times, interconnected in ultra-high-speed communication networks and consuming less electrical power in order to be supplied by batteries and clean renewable energy solutions.

For almost two decades now, classical VLSI laws such as Moore’s and Dennard’s cannot be applied anymore for embedding twice as many transistors in the same silicon area every two years and keeping the energy density constant at the same time. The most feasible solution for mitigating this problem is designing DSAs (Domain-Specific Architectures) like application-specific hardware accelerators. Hardware accelerators replace the necessity of implementing domain specific algorithms programmatically by embedding hardware implementation variants of the same algorithms in modules running in parallel with the software developed for classical CPUs.

An electronic field which can benefit from using domain-specific architectures instead of classical general-purpose microcontrollers is Digital Signal Processing (DSP). Designing logical circuits or complex digital systems won’t be possible today without using logic analyzers, protocol decoders, digital oscilloscopes, and digital recorders. These tools are used in the processes of prototyping and verifying digital systems by recording, displaying, decoding, and analyzing internal or external signals.

This article proposes an example of a domain-specific architecture, a Digital Acquisition System, named FpgaDaqEth, acquiring data from 32 digital channels at 1 MS/s maximum acquisition rate, deployed on FPGA, operating at 100 MHz, using DDR3 RAM memory and 100 Mbps Ethernet for the communication with hosting PC running a custom GUI (graphical user interface) application. This design offers between 8x and 43.34x better propagation delay (constant 20 ns) for performing and outputting logical operations over multiple inputs (between 2 and 31 signals) than a general-purpose microcontroller which runs at 6x times higher frequency. It is also initiating UDP transmissions containing digital records and their timestamps 19.31x times faster than a Xilinx (now AMD) MicroBlaze processor implementation running at 2x times higher frequency on the same FPGA. The solution can detect changes in parameters of PWM inputs and send them to the hosting PC right after the first cycle of the modified signal ends.

The proposed design is deployed on AMD XC7A100T FPGA as a standalone solution and may be integrated as processor extension for RISC-V cores in a future project.
Dental pulp regeneration via dental pulp stem cells conditioned media and curcumin-loaded nanocomposite hydrogel: an in vitro and in vivo study
Authors: Ma Bei’er , Xu Ren
Published: August 2024

Dental pulp regeneration has emerged as a promising area of research in dentistry, aiming to restore damaged or diseased dental pulp, which is crucial for maintaining tooth vitality and function. There is a critical need to develop filler materials to treat dental pulp injuries. In the current research, we developed a nanocomposite delivery system for dental pulp stem cells (DPSCs) conditioned media and curcumin-loaded chitosan nanoparticles (CURCNPs) for treating dental pulp tissue injury in a rat model. The delivery system was biocompatible with DPSCs and protected them from oxidative stress. In addition, the developed nanocomposite hydrogel exhibited remarkable anti-inflammatory and anti-oxidative functions. An in vivo study showed that dental pulp tissues treated with hydrogels loaded with the conditioned media and CURCNPs had significantly higher healing activity than other groups. This healing effect was associated with the upregulation of VEGF and TGF-β and the downregulation of TNF-α and IL-6. In summary, our nanocomposite delivery system, integrating DPSCs conditioned media and CURCNPs, demonstrates promising biocompatibility and remarkable healing potential for treating dental pulp injuries, suggesting clinical applicability.
ECG Arrhythmia Measurement and Classification for Portable Monitoring
Authors: P Ajitha Gladis K. , Ahilan A , Muthukumaran N , Jenifer L
Published: August 2024

Globally, cardiovascular disease kills more than 500000 people every year, thus becoming the primary reason for death. Nevertheless, cardiovascular health monitoring is essential for accurate analysis and therapy of heart disease. In this work, a novel deep learning-based StrIppeD NAS-Network (SID-NASNet) for arrhythmia categorization into octa-classes with electrocardiogram (ECG) signals is presented. First, the ECG signals are recorded in real time using 12-lead electrodes. Then, the Discrete Wavelet Transform (DWT) is used to denoise the signals to reduce repetition and increase resilience. The noise-free ECG signals are fed into a K-means clustering algorithm to group ECG signal segments into a set number of clusters to identify patterns that may indicate heart abnormalities. Subsequently, the deep learning-based NASNet with Stripped convolutional layers is used to detect ECG irregularities of arrhythmia. Each sample point is examined for its local fractal dimension before extracting the heartbeat waveforms within a predetermined window length. A bio-inspired Dingo Optimization (DO) algorithm is used in the SID-NASNet to normalize the parameters to improve the efficiency of the network with low network complexity. The efficiency of the proposed SID-NASNet is assessed with specificity, accuracy, precision, F1 score and recall based on the MIT-BIH arrhythmia dataset. From the test results, the proposed SID-NASNet achieves an accuracy of 98.22% for effective categorization of ECG signals. The proposed SID-NASNet improves the overall accuracy of 1.24%, 3.76%, 1.87%, and 0.22% better than ECG-NET, Deep Learning (DL)-based GAN, 1D-CNN, and GAN-Long-Short Term Memory (LSTM), respectively.
Subsidies in the Renewable Energy Industry Under the World Trade Organization Regime and Suggestions for Vietnam
Authors: Ngoc Tran Phuong , Bao Nguyen Van
Published: August 2024

With the continuous increase in greenhouse gas emissions and global average temperature, the effects of climate change are predicted to grow. In Vietnam, growing demand for subsidy programs to attract renewable energy investments must be balanced with the government’s obligation to ensure their conformity with the World Trade Organization (WTO) regulations. This article analyzes subsidy-related rules in WTO agreements and reviews countervailing investigations on renewable energy-related products from Vietnam. Based on the analysis, the authors propose that the Vietnamese government implement subsidy programs in accordance with the WTO’s conditions.
Reviewing the Regulatory Text on Social and Economic Rights
Authors: Linares-Vizcarra Mitzi Lourdes del Carmen , Lukich-Valdivia Milena Eloísa , Montero-Zuñiga Evelyn Trinidad
Published: August 2024

Objective: Rethink the regulatory text on social and economic rights of the Peruvian Constitution of 1993.
 
Theoretical Framework: The legal doctrine on social and economic rights, its evolution, theories of recognition, international treaties and national legislation are reviewed. The challenges in its implementation are analyzed, including national conflicts, automation, technology and consumer law.
 
Method: A qualitative approach is used based on documentary and comparative analysis of legal texts, international treaties and previous studies. The critical analysis of problematic cases in the implementation of these rights is included. It is an exploratory, descriptive and historical research, using recent secondary information.
 
Results and Discussion: Inconsistencies and weaknesses are revealed in the current regulatory text, making it difficult to fully realize social and economic rights. Legislative reforms and judicial reinterpretation are proposed, emphasizing the need for a more inclusive and effective approach.
 
Research Implications: A guide is offered for legislators, judges and academics to improve the regulatory framework on social and economic rights, influencing future legislative reforms and judicial interpretation.
 
Originality/Value: The article is original for its critical and propositional approach, providing a detailed analysis of current deficiencies and practical solutions, highlighting its relevance in the contemporary context of human rights.
Seeding Density Directly Influences Crambe Productivity
Authors: Nascimento Lucas Marquezan , Vendruscolo Eduardo Pradi , Camargo Fernando Ribeiro Teles de , Coelho Marcos , Bastos Fernanda Espíndola Assumpção , Araújo Tassila Aparecida do Nascimento de
Published: August 2024

Objective: The objective of this study was to evaluate the development and production characteristics of crambe, under different planting densities and different spacing between rows.
 
Theoretical Framework: For crops that are still little explored, such as crambe, sowing management in new regions lacks information that would enable rural producers to obtain greater profitability.
 
Method: Two cycles were conducted, in which six treatments were used, consisting of a combination of two different spacings between rows (20 and 40 cm) and three final plant populations (400, 600 and 800 thousand plants ha-1). The characteristics of plant height, stem diameter, number of branches, number of leaves, total dry mass of plants, hectoliter weight of grains and productivity were evaluated.
 
Results and Discussion: The biometric characteristics of the plants and the hectoliter weight of the grains were not altered by the treatments, with the exception of the height of plants in the second cycle, in which plants grown at the lowest density had their height reduced. However, productivity was higher for dense crops, with the treatment consisting of 800 thousand plants ha-1 being superior to the others.
 
Research Implications: Determine the best population of crambe plants at different planting times, aiming to obtain the best management for the producer.
 
Originality/Value: Crambe cultivation has the potential to be produced in different soil and climate conditions. However, research on cultivation in the Cerrado biome is still scarce, and there is a need for information on crop management.
Improving Student Learning Outcomes Through the Probing Prompting Learning Model on Trigonometric Ratios in Right-Angled Triangles in Class X-MPLB-A at SMK Negeri 1 Suwawa
Authors: Daluta Alpin , Machmud Tedy , A. Y. Pauweni Khardiyawan
Published: August 2024

This classroom action research aims to improve student learning outcomes on trigonometric ratios in right-angled triangles using the probing prompting learning model. This study is a classroom action research conducted at SMK Negeri 1 Suwawa during the even semester of the 2022/2023 academic year. The research involved 20 students and a teacher as subjects. The instruments used included teacher observation sheets, student observation sheets, and learning outcome tests. The research was conducted over 2 cycles. The results showed that the teacher's activity observations, which reached good and very good categories, increased from 80.94% to 80.95%. Similarly, the student observations that reached good and very good categories also increased from 74.99% to 79.16%. Student learning outcomes improved from 80% to 90%. All assessment aspects met the learning success indicators in the second cycle through the application of the probing prompting learning model. Based on this research, there are benefits to applying the probing prompting learning model, as it can enhance students' mathematics learning outcomes and improve their comprehension of mathematics.
Analisis Limpasan Air Permukaan Menggunakan Hechms Akibat Perubahan Tutupan Lahan Di Kecamatan Jati Agung Lampung Selatan
Authors: Aziz Syarifuddin
Published: August 2024

Tuntutan terhadap kebutuhan ruang untuk aktivitas manusia mendorong terjadinya alih fungsi lahan pertanian karena lahan pertanian memiliki sistem sewa tanah (land- rent) yang relatif rendah dibanding penggunaan lahan lain (Murdaningsih dkk., 2017). Meningkatnya kawasan terbangun secara langsung berakibat meningkatnya koefisien limpasan, sehingga limpasan air permukaan akan meningkat seiring dengan meningkatnya intensitas hujan (Wijaya dkk., 2014). Penelitian ini dilakukan di sub DAS Way Kandis Kecamatan Jati Agung Kabupaten Lampung Selatan, dengan luas lahan sebesar 164,47 km2. Tujuan penelitian ini adalah untuk menganalisis laju alih fungsi lahan dan besaran limpasan air permukaan akibat alih fungsi lahan di Kecamatan Jati Agung, Kabupaten Lampung Selatan. Alih fungsi lahan yang terjadi dari tahun 2016 sampai tahun 2020 didominasi oleh perubahan lahan perkebunan, pemukiman dan pertanian lahan kering campur. Dari hasil simulasi HEC-HMS diperoleh nilai debit puncak dan volume limpasan air tahun 2016 sebesar 215,80 m3/s dan 13.989.100 m3. Pada tahun 2020 terjadi peningkatan debit puncak dan volume limpasan air sebesar 246,40 m3/s dan 15.444.100 m3. Peningkatan debit puncak dan volume limpasan air terjadi pada setiap tahun. Hal ini disebabkan karena adanya perubahan koefisien limpasan (CN).
Mosaic embryo transfer after pre-implantation genetic testing for structural rearrangement: a case study
Authors: Mahalingam Shweta , Rasalkar Rashmi , Lallar Meenakshi , Pradhan Avinash , Khairnar Sneha , Devanboo Angela , Venkataswamy Eswarachari , Kariyaiah Satish , Ramprasad Vedam , Kadam Priya
Published: August 2024

Background: Identifying the cause of recurrent pregnancy loss (RPL) helps in the direct management of future pregnancies. In 3%-4% of cases, a chromosomal structural rearrangement is identified in the couple. Pre-implantation genetic testing - structural rearrangements (PGT-SR) is an accepted practice for such couples opting for pregnancy through in-vitro fertilization. However, the result interpretation and clinical outcome for mosaic embryo transfer have limited predictions.
Case Presentation: In this case study, we describe the genetic tests involved in establishing the cause of RPL followed by management through PGT and prenatal diagnosis. The couple was identified with a structural rearrangement and opted for PGT-SR (structural rearrangement) which revealed a mosaic embryo involving multiple chromosomes. The case study describes the implication of the transfer of mosaic embryos, followed up with prenatal tests with complex results, its interpretation, and genetic counseling.
Conclusion: The case reiterates the benefit of thorough genetic evaluation for pregnancy management by using multiple genetic tests for couples with RPL. It aids in decision-making for complex genetic results in prenatal scenarios.
Computational Studies of Rhubarb’s Anthraquinone Glycosides as Anti-Diabetic Drug Candidates through Sodium-Glucose Cotransporter-2 Inhibition
Authors: Putra Wira Eka , Sustiprijatno  , Hidayatullah Arief , Widiastuti Diana , Heikal Muhammad Fikri
Published: August 2024

Type 2 diabetes mellitus continues to pose a significant global health concern, warranting increased attention. This metabolic disorder is influenced by various factors, such as lifestyle, diet, environment, and genetics. While several approaches have been developed to address the incidence of type 2 diabetes mellitus, current treatments remain inadequate and necessitate further improvement. In this study, our objective was to assess the potential antidiabetic efficacy of anthraquinone glycosides present in rhubarb (specifically physcion diglucoside and aloe-emodin-8-glucoside) as potential inhibitors of the sodium-glucose cotransporter-2. We employed an in silico study to evaluate their inhibitory properties. The computational prediction was performed included the target protein, ligands retrieval, and preparation. Furthermore, the molecular docking process was conducted to assess the interaction between the target protein and ligands. Subsequently, data visualization and analysis were performed. Various indicators were evaluated, including the characteristics of the target molecule and drug candidates, binding affinity scores, interaction positions, types of chemical interactions, amino acid residues involved, hydrophobicity, formation of hydrogen bonds, interpolated charge, and ionizability. These comprehensive evaluations provided valuable insights into the molecular interactions and potential efficacy of the tested compounds. In this computational study, we demonstrated that the both rhubarb anthraquinones, physcion diglucoside and aloe-emodin-8-glucoside, have a great potential as antidiabetic agent by inhibiting the action of the sodium-glucose cotransporter-2. Thus, the inactive the sodium-glucose cotransporter-2 can prevent the excessive number of glucose plasma level in type two diabetes mellitus people.
Enhancing Early Cancer Detection: An Investigation of DNA Sequences and Machine Learning
Authors: Ganie Aadil Gani , Dadvandipour Samad
Published: August 2024

The study aimed to address the global challenge of cancer-related fatalities by investigating the feasibility of identifying or predicting the early-stage presence of three distinct forms of cancers, colon, thyroid and urothelial carcinoma, via the analysis of raw DNA sequences. The data, sourced from the NCBI database, underwent a series of pre-processing techniques, including kmer analysis, under-sampling and count vectorization. Subsequently, machine learning algorithms, including logistic regression and multinomial Naive Bayes, were implemented on the pre-processed data with logistic regression demonstrating superior accuracy of 80.10% with calibration and 78.54% without calibration. To enhance the model's extrapolative capabilities, the logistic regression model was further calibrated utilizing the sigmoid method. The final model was deployed through the utilization of the open-source streamlit package.
Nano equipamento de proteção individual contra SARS-CoV-2: Insights de uma análise bibliométrica de publicações e patentes recentes
Authors: Da Conceição Oliveira Meliza , Yurgel Virginia Campello , Vaiss Daniela Pastorim , Barros Paula Alice , Dora Cristiana Lima
Published: August 2024

No contexto da COVID-19, uma doença altamente contagiosa, o uso de equipamentos de proteção individual (EPI) é de grande importância, tanto pelos profissionais de saúde quanto pela comunidade em geral. Como a transmissão do vírus se dá por inalação ou contato direto com gotículas infecciosas, o uso de EPIs, principalmente máscaras faciais, tornou-se o “novo normal” para as sociedades. No entanto, para melhorar o potencial de filtragem e eliminação de vírus, bem como a respirabilidade e conforto das máscaras, muitos estudos têm sido realizados nesta área. Este trabalho avaliou artigos e patentes sobre o tema EPI nanotecnológico por meio de uma análise bibliométrica. Os dados foram coletados de 2016 a 2021, extraídos de bases de dados como PubMed e Web Of Science, e analisados por meio de técnicas bibliométricas. Além disso, foi realizada uma revisão de patentes para avaliar as invenções atuais relacionadas à máscara de proteção. Os resultados mostram que os EUA produziram o maior número de publicações acadêmicas relacionadas à nanotecnologia e equipamentos de proteção individual, sendo que a Índia e o Brasil também se destacaram no número de publicações. Entre os nanomateriais mais discutidos para associação em EPI estão as nanopartículas e nanofibras metálicas, principalmente as nanopartículas de prata. Além disso, por meio dos resultados, destacou-se o aumento de publicações sobre o tema nos últimos anos, e acredita-se que o crescimento continuará por tempo indeterminado, devido à prevenção de pandemias atuais e futuras.
Survey of Invasive Plants at Hin Nam No National Park, Khammoune Province, Laos
Authors: Tai Vu Anh , Thi Thuy Van Tran
Published: August 2024

This paper represented the first survey of invasive plants at the Hin Nam No National Park, Khammoune province, Laos. We identified 33 invasive species among 78 alliance species. These invasive species cause an impact on the open habitats of the national park, mostly to the secondary evergreen scrubs, secondary semi-deciduous scrubs, secondary evergreen grasslands, secondary semi-deciduous grasslands, abandoned cultivated lands, residential areas, and sometimes to the regenerating evergreen forest or regenerating semi-deciduous forest. The worst impacting species that were first observed are Lantana (Lantana camara), Siam weed (Chromolaena odorata), Blackjack (Bidens pilosa). The medium-impacting species are Mysore thorn (Biancaea decapetala) and Billy goat weed (Ageratum conyzoides). This research provides foundational insights to the national park and local stakeholders about biological conservation and potential invasive plant controlling activities, such as focusing on controlling invasive plants in the borders of the national park. It is necessary to conduct a detailed study to identify exactly the impact of each species, including the impacted areas, the impacting pathway, and controlling methods. The research also recommends that Centre for Agriculture and Biosciences International (CABI) change the alliance status of 12 species to native and reconsider Blue porterweed (Stachytarpheta jamaicensis) as an alliance species.
Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells
Authors: Oktavia Sri , Amir Arni , Wahyuni Fatma Sri , Hasmiwati Hasmiwati
Published: August 2024

Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).
Diet Rendah Protein pada Gagal Ginjal Kronik
Authors: Evynatra Evynatra , Sulastri Delmi
Published: August 2024

Tujuan: Menyediakan informasi mengenai diet rendah protein pada gagal ginjal kronik. Metode: Penulisan artikel ini menggunakan metode literature review. Sumber yang dipakai berupa artikel dari jurnal internasional. Artikel diambil dalam menggunakan Bahasa Inggris. Pencarian sumber artikel menggunakan bantuan mesin pencari Google Scholar dan PubMed. Hasil: Diet rendah protein (Low Protein Diet/LPD, 0,6-0,8 g/kg/hari) dan bahkan diet protein sangat rendah (Very-Low Protein Diet/vLPD, 0,3-0,4 g/kg/hari) direkomendasikan untuk pasien CKD. Diet rendah protein (Low Protein Diet/LPD) memiliki banyak keunggulan dalam pengelolaan pasien CKD dengan mengurangi produk limbah nitrogen dan mengurangi beban kerja ginjal melalui penurunan tekanan intraglomerular, yang memiliki efek protektif ginjal, terutama pada mereka yang memiliki cadangan fungsi nefron yang berkurang. Kesimpulan: Pengelolaan pasien Chronic Kidney Disease (CKD) dengan diet protein rendah (LPD) telah diidentifikasi sebagai strategi potensial untuk mengendalikan gejala uremik dan komplikasi metabolik, serta menunda kebutuhan untuk dialisis. Meskipun memiliki manfaat potensial, keberatan terkait Protein-Energy Wasting (PEW) telah membatasi adopsi luas strategi ini di kalangan klinisi. Penting untuk menekankan bahwa penerapan LPD memerlukan pemantauan gizi yang ketat. Sebuah pendekatan multidisiplin, melibatkan spesialis seperti dokter, perawat, ahli gizi, dan pekerja sosial, diperlukan untuk memastikan keberhasilan dan keamanan penerapan LPD dalam pengelolaan pasien CKD.
FAKTOR DETERMINASI PENGHINDARAN PAJAK DENGAN UKURAN PERUSAHAAN SEBAGAI PEMODERASI
Authors: Devi Margaretha  , Harti Budi Yanti
Published: August 2024

Tujuan dilakukan penelitian ini untuk menganalisis faktor determinasi penghindaran pajak yang dimoderasi oleh ukuran perusahaan. Data penelitian yaitu data sekunder didapatkan dari website BEI dan website resmi perusahaan terkait. Pengambilan sampel dengan teknik purposive sampling dan analisis data dengan teknik regresi data panel oleh aplikasi Eviews. Penelitian ini menggunakan perusahaan sektor properti dan real estate tercatat di BEI selama periode 2021-2023 sejumlah 207 sampel. Hasil pengujian hipotesis yang dilakukan dalam penelitian ini membuktikan bahwa harga transfer berpengaruh positif terhadap penghindaran pajak, tanggung jawab sosial berpengaruh negatif terhadap penghindaran pajak, komite audit tidak berpengaruh negatif terhadap penghindaran pajak, ukuran perusahaan memperkuat pengaruh harga transfer dan tanggung jawab sosial terhadap penghindaran pajak, dan ukuran perusahaan tidak memperkuat secara positif pengaruh komite audit terhadap penghindaran pajak.
Building brand credibility to increase consumer purchase intention: The role of influencer emotional attachment
Authors: Rahayu Fatik , Siregar Raymond , Risde Kahti Ramadhia , Nurulita Dyahayu Amanda , Wijarnako Faiq Raihan , Wijarnako Khansa Fara , Ying Luo
Published: August 2024

Influencer marketing is becoming more common in online shopping on social media, leading influencers to focus on improving the quality and uniqueness of their content. Previous studies have mainly focused on identifying influencer traits that affect the effectiveness of influencer marketing. This study aims to fill the gap by complementing and expanding this research using the meaning transfer model to investigate the role of emotional attachment in building brand credibility and increasing consumer purchase intention in Indonesia. Data from 268 participants were collected through questionnaires, and structural equation modeling was used for analysis. The results indicated that interactivity had a positive impact on influencer authenticity. Additionally, authenticity influences emotional attachment, affecting brand credibility and purchase intention. Based on these results, influencers should strive to be professional, honest, and objective and understand their followers' characteristics to enhance emotional attachment.
FAKTOR-FAKTOR YANG MEMPENGARUHI PENERIMAAN PAJAK : ANALISIS 6 NEGARA DI ASIA TENGGARA
Authors: Septian Roy , Idrianita Anis
Published: August 2024

Penelitian ini bertujuan untuk menganalisis pengaruh tarif PPN, Produk Domestik Bruto (PDB), tingkat inflasi, dan tingkat pengangguran terhadap penerimaan pajak di enam negara Asia Tenggara yang terpilih. Metode penelitian yang digunakan adalah kuantitatif dengan pendekatan studi kepustakaan. Data diambil dari website World Bank yang meliputi persentase tarif, Gross Domestic Products, tingkat inflasi, dan tingkat pengangguran yang berasal Negara Indonesia, Singapura, Malaysia, Filipina, Thailand, dan Vietnam. Penelitian ini dapat memberikan kontribusi yang signifikan terhadap perumusan kebijakan publik. Penemuan adanya pengaruh penentuan tarif PPN, pengendalian tingkat inflasi dan pengendalian tingkat pengangguran dapat memberikan efek terhadap penerimaan pajak dapat membantu pemerintah dalam merancang kebijakan fiskal yang lebih efektif dan efisien. Aplikasi praktis yang signifikan pada penelitian ini adalah dapat menjadi acuan kesiapan ekonomi aktual masyarakat Indonesia terhadap kenaikan tarif PPN menjadi 12% pada tahun 2025.
PENGARUH OPINI AUDIT, KUALITAS AUDIT DAN KOMPLEKSITAS OPERASI PERUSAHAAN TERHADAP AUDIT REPORT LAG DENGAN EFEKTIVITAS KOMITE AUDIT SEBAGAI VARIABEL MODERASI
Authors: Intan Desiani  , Vinola Herawaty
Published: August 2024

Penelitian ini bertujuan untuk mengevaluasi dan memeriksa efek dari Opini Audit, Kualitas Audit, serta Kompleksitas Operasi Perusahaan terhadap Audit Report Lag dengan Efektivitas Komite Audit sebagai variabel Moderasi. Data sekunder yang digunakan dalam penelitian ini diperoleh dari laporan keuangan dan laporan tahunan perusahaan. Populasi penelitian ini mencakup perusahaan sektor Consumer Non-Cyclicals yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2020-2022. Metode purposive sampling dengan kriteria tertentu digunakan untuk memperoleh sampel dari 81 perusahaan selama periode 2020-2022. Penelitian ini menunjukkan bahwa kualitas audit berdampak negatif pada keterlambatan laporan audit, sedangkan opini audit, kompleksitas operasional perusahaan, dan efektivitas komite audit tidak mempengaruhi keterlambatan tersebut.
Effect of vitamin D supplementation on lung function in chronic obstructive pulmonary disease patients
Authors: Kirana Annisa Nurul , Sunardi Diana
Published: August 2024

Background: Chronic obstructive pulmonary disease (COPD) is characterized by progressive and persistent airflow obstruction together with an increased chronic inflammatory response, primarily caused by environmental exposure and smoking habit. Vitamin D deficiency is associated with increased rates of exacerbation and hospitalization in COPD patients. Recent studies have indicated a direct correlation between vitamin D deficiency and the severity of COPD, suggesting that acute exacerbation could be prevented with vitamin D supplementation. Some studies propose that correcting the serum vitamin D level may improve the prognosis for COPD patients experiencing respiratory tract infections.
Objective: The aim of this study was to determine the effect of vitamin D supplementation for lung function in COPD patient.
Methods: Literature search was carried out by advanced searching on Pubmed, Cochrane Library, and Scopus using a combination of MeSH Terms and Title/Abstract. Following screening for duplications, the literature obtained then screened according to predetermined eligibility criteria. The appropriate literatures were critically reviewed and the level of evidence in accordance with the Oxford Center for Evidence Based Medicine.
Results: One meta-analysis and three randomized controlled trial (RCT) met the PICO and eligibility criteria that had been set.  Three studies concluded that vitamin D supplementation enhanced lung function in COPD patient. Vitamin D deficiency is common in COPD patients, so it is recommended to check vitamin D levels before vitamin D supplementation.
Conclusion: Vitamin D administration can improve lung function and prevent acute exacerbation in COPD patients.
Vitamin D deficiency and risk of myasthenia gravis
Authors: Wijayanthie Nadiyah , Wulandari Yohannessa , Rahmawati Anni
Published: August 2024

Background: An autoimmune condition known as myasthenia gravis (MG) targets the receptors for neurotransmitter acetylcholine at the neuromuscular junction, resulting in inhibition of muscle contraction. This results in muscle weakness resulting in a decrease in quality of life. Immunoregulation and muscle contractility are known to play a role in vitamin D. Literature on how vitamin D affects myasthenia gravis risk has not been widely carried out and the results are still controversial.Objective: To evaluate the association between vitamin D and MG risk.Methods: The search of the literature was conducted from PubMed, Cochrane Library, Embase, and EBSCOhost with the eligibility criteria determined by the authors. The literature search was using MeSH Term, text word, and title/abstract.Results: Two articles were selected and critically appraised. The first article shows an odds ratio of 3.96 (CI95 1.26 to 12.52), which means that myasthenia gravis has vitamin D levels almost 4 times lower than healthy population. A case-control study that followed described a comparison of mean levels of vitamin D (25(OH)D) in myasthenia gravis (mean, 18.8±8.4 ng/mL) compared to healthy controls (26.3±6.1). ng/mL) (p <0.05). Both studies revealed a strong interaction between MG and vitamin D inadequacy. Conclusion: Both studies above support the theory that vitamin D deficiency is associated with the risk of developing MG.
Impact of an oral nutritional supplement on nutritional status in older adults with malnutrition: A randomized controlled trial
Authors: Jayawardena Ranil , Wickramawardhane Prasani
Published: August 2024

Background: The aging population is expanding at an unprecedented rate, leading to a significant increase in the prevalence of malnutrition among older adults. Oral Nutritional Supplements (ONS) have emerged as a widely accepted strategy to address the nutritional needs of this demographic.
Objective: This study aimed to evaluate the impact of an ONS on the nutritional status of malnourished older adults.
Methods: This was an open-label, randomized-controlled, parallel-group, single-centered study. Recruitment criteria were age ≥60 years, and mini nutrition assessment-short form (MNA-SF) score ≤11. A total of 50 participants were randomly assigned to the intervention (IG) and control (CG) groups (1:1 ratio). The IG received 200 mL of ONS as a bedtime drink for 12 weeks, while the CG received 200 mL of water. Nutrition status, biochemical analysis, and dietary assessment were performed at the beginning and end of the study.
Results: Forty-two participants (IG: n=20, and CG: n=22) completed the study. After 12 weeks, the IG showed a significant improvement in the MNA-SF score (p<0.001) compared to the CG (p=0.118). The IG experienced a substantial increment in the vitamin D level (p=0.002). No significant improvements were found in the serum albumin and haemoglobin levels in either group. The intervention led to significant increases in daily intake of energy (p<0.001), carbohydrate (p=0.013), protein (p<0.001), and fat (p<0.001) in comparison to the control group.
Conclusion: Supplementing with an ONS, along with a regular diet, significantly improved nutritional status, some biochemical parameters, and daily intake of energy and macronutrients in older adults with malnutrition.