bluuebunny/crossref_metadata_2025 huggingface dataset:
The Interplay between Muscular Grip Strength and Bone Mineral Density with Consideration of Metabolic and Endocrine Parameters in Individuals with Turner Syndrome
Authors: Krzyścin Mariola , Gruca-Stryjak Karolina , Soszka-Przepiera Ewelina , Syrenicz Igor , Przepiera Adam , Cymbaluk-Płoska Aneta , Bumbulienė Žana , Sowińska-Przepiera Elżbieta
Published: November 2023

Introduction: Patients with Turner syndrome (TS) often face skeletal and muscular challenges, including reduced bone mineral density (BMD) and muscle weakness. This comprehensive study sheds light on the complex interplay between muscle strength, BMD, and metabolic and endocrine parameters in TS and healthy subjects. Methods: A cross-sectional study involving 42 TS patients and 70 healthy women was conducted. All patients had their BMD determined in the L1–L4 lumbar spine section and in the whole skeleton as well as the parameters of body fat mass (BF), and visceral fat mass (VF) were also determined. The maximum gripping force was measured with a hydraulic manual dynamometer. In addition, a number of blood hormonal and metabolic parameters were determined. Results: In the TS group, hand grip strength correlated positively with triglyceride levels but not with BMD. Healthy individuals had a positive link between hand grip strength and BMD, while patients with TS did not show a significant association between the two. A trend suggested that longer recombinant human growth hormone (rhGH) therapy might improve BMD in the L1–L4 region. Multiple linear regression analysis revealed that muscle strength assessment may be a potential exponent of reduced BMD, and also used clinically in young adult women but not in individuals with TS. Conclusions: The relationship between BMD variables and hand grip might differ between the two groups, potentially indicating distinct musculoskeletal characteristics in TS patients. Longer rhGH therapy in TS patients may have a positive effect on BMD in the L1–L4 region. Understanding the intricate relationships between these factors is important for optimizing clinical management strategies and improving the quality of life for TS patients.
Influence of Rifamycin on Survival in Patients with Concomitant Lung Cancer and Pulmonary Tuberculosis
Authors: Lee Ho-Sheng , Wei Yu-Feng , Shu Chin-Chung
Published: November 2023

Background: The coexistence of lung cancer and tuberculosis is not rare. Rifamycin plays a pivotal role in anti-tuberculosis therapy. However, its potential impact on the liver metabolism of oncology drugs raises concerns. We performed this study to explore whether Rifamycin affects the survival of patients with tuberculosis and lung cancer. Methods: Drawing from the Taiwan National Health Insurance Research Database, we identified patients diagnosed with concurrent lung cancer and tuberculosis between 2000 and 2014. Patients were categorized based on whether they underwent rifamycin-inclusive or rifamycin-exempt anti-tuberculosis therapy. Subsequently, we paired them at a 1:1 ratio and evaluated the mortality risk over a two-year span. Results: Out of the study participants, 1558 (81.4%) received rifamycin-based anti-tuberculosis therapy, while 356 (18.6%) underwent a rifamycin-free regimen. Analysis revealed no marked variance in the biennial mortality rate between the groups (adjusted hazard ratio: 1.33, 95% confidence interval 0.93–1.90, p = 0.1238). When focusing on the matched sets comprising 127 individuals in each group, the data did not indicate a significant link between rifamycin and a heightened two-year mortality risk (adjusted hazard ratio: 1.00, 95% confidence interval 0.86–1.18, p = 0.9538). Conclusions: For individuals with concomitant lung cancer and tuberculosis, rifamycin’s administration did not adversely influence two-year survival. Thus, rifamycin-containing anti-TB regimens should be prescribed for the indicated patients.
Textural Analysis of Magnetic Resonance Images as an Additional Evaluation Tool of Parotid Glands in Sjögren—Primarily Findings
Authors: Grzywińska Małgorzata , Karwecka Magdalena , Pomorska Anna , Irga-Jaworska Ninela , Świętoń Dominik
Published: November 2023

Magnetic Resonance Imaging (MRI) plays a leading role in diagnosing soft tissue pathologies, especially in the head and neck. It is increasingly popular for evaluating salivary gland issues like neoplasms and Sjogren’s Syndrome. Advanced MRI methods, including MRI sialography and texture analysis, offer non-invasive alternatives, enhancing MRI’s role. This study focused on the relationship between the apparent diffusion coefficient (ADC) and T2-weighted MRI sialography and texture analysis (TA) of parotid glands in children with and without Sjogren’s Syndrome (SS). Using 3.0 Tesla MRI with DWI and T2-weighted imaging, expended texture analysis, first-order statistics (FSOs), second-order, and higher-order statistics were conducted. The results showed significant differences in parotid ADC values, with lower values in the SS group, particularly in cases of higher disease activity. Lower kurtosis values were associated with more severe Tonami Scale grades. FSO parameters correlated well with the texture analysis from T2-weighted images, indicating promise in grading parotid gland inflammation. However, further research is needed to understand the impact of variables like binning and region of interest (ROI) size. This study highlights the potential of texture analysis for assessing parotid gland inflammation and emphasizes the need for more investigations in this area.
Role of Lipid Rafts on LRP8 Signaling Triggered by Anti-β2-GPI Antibodies in Endothelial Cells
Authors: Riitano Gloria , Capozzi Antonella , Recalchi Serena , Augusto Mariaconcetta , Conti Fabrizio , Misasi Roberta , Garofalo Tina , Sorice Maurizio , Manganelli Valeria
Published: November 2023

Antiphospholipid antibody syndrome is an autoimmune disease characterized by thrombosis and/or pregnancy morbidity in association with circulating antiphospholipid antibodies, mainly anti-β2 glycoprotein 1 antibodies (anti-β2-GPI antibodies). Previous studies demonstrated that the signaling pathway may involve lipid rafts, plasma membrane microdomains enriched in glycosphingolipid and cholesterol. In this study, we analyzed the signaling pathway of LRP8/ApoER2, a putative receptor of anti-β2-GPI antibodies, through lipid rafts in human endothelial cells. LRP8, Dab2 and endothelial nitric oxide synthase (e-NOS) phosphorylation were evaluated using Western blot, Nitric Oxide (NO) production with cytofluorimetric analysis, LRP8 enrichment in lipid rafts via sucrose gradient fractionation, and scanning confocal microscopy analysis of its association with ganglioside GM1 was also conducted. The analyses demonstrated that affinity-purified anti-β2-GPI antibodies induced LRP8 and Dab-2 phosphorylation, together with a significant decrease in e-NOS phosphorylation, with consequent decrease in NO intracellular production. These effects were almost completely prevented by Methyl-β-cyclodextrin (MβCD), indicating the involvement of lipid rafts. It was supported with the observation of LRP8 enrichment in lipid raft fractions and its association with ganglioside GM1, detected with scanning confocal microscopy. These findings demonstrate that LRP8 signaling triggered by anti-β2-GPI antibodies in endothelial cells occurs through lipid rafts. It represents a new task for valuable therapeutic approaches, such as raft-targeted therapy, including cyclodextrins and statins.
Uncovering the Neural Correlates of Anhedonia Subtypes in Major Depressive Disorder: Implications for Intervention Strategies
Authors: Ding Yudan , Ou Yangpan , Yan Haohao , Liu Feng , Li Huabing , Li Ping , Xie Guangrong , Cui Xilong , Guo Wenbin
Published: November 2023

Major depressive disorder (MDD) represents a serious public health concern, negatively affecting individuals’ quality of life and making a substantial contribution to the global burden of disease. Anhedonia is a core symptom of MDD and is associated with poor treatment outcomes. Variability in anhedonia components within MDD has been observed, suggesting heterogeneity in psychopathology across subgroups. However, little is known about anhedonia subgroups in MDD and their underlying neural correlates across subgroups. To address this question, we employed a hierarchical cluster analysis based on Temporal Experience of Pleasure Scale subscales in 60 first-episode, drug-naive MDD patients and 32 healthy controls. Then we conducted a connectome-wide association study and whole-brain voxel-wise functional analyses for identified subgroups. There were three main findings: (1) three subgroups with different anhedonia profiles were identified using a data mining approach; (2) several parts of the reward network (especially pallidum and dorsal striatum) were associated with anticipatory and consummatory pleasure; (3) different patterns of within- and between-network connectivity contributed to the disparities of anhedonia profiles across three MDD subgroups. Here, we show that anhedonia in MDD is not uniform and can be categorized into distinct subgroups, and our research contributes to the understanding of neural underpinnings, offering potential treatment directions. This work emphasizes the need for tailored approaches in the complex landscape of MDD. The identification of homogeneous, stable, and neurobiologically valid MDD subtypes could significantly enhance our comprehension and management of this multifaceted condition.
Integrating Fused Deposition Modeling and Melt Electrowriting for Engineering Branched Vasculature
Authors: Thorsnes Quinn S. , Turner Paul R. , Ali Mohammed Azam , Cabral Jaydee D.
Published: November 2023

We demonstrate for the first time the combination of two additive manufacturing technologies used in tandem, fused deposition modelling (FDM) and melt electrowriting (MEW), to increase the range of possible MEW structures, with a focus on creating branched, hollow scaffolds for vascularization. First, computer-aided design (CAD) was used to design branched mold halves which were then used to FDM print conductive polylactic acid (cPLA) molds. Next, MEW was performed over the top of these FDM cPLA molds using polycaprolactone (PCL), an FDA-approved biomaterial. After the removal of the newly constructed MEW scaffolds from the FDM molds, complementary MEW scaffold halves were heat-melded together by placing the flat surfaces of each half onto a temperature-controlled platform, then pressing the heated halves together, and finally allowing them to cool to create branched, hollow constructs. This hybrid technique permitted the direct fabrication of hollow MEW structures that would otherwise not be possible to achieve using MEW alone. The scaffolds then underwent in vitro physical and biological testing. Specifically, dynamic mechanical analysis showed the scaffolds had an anisotropic stiffness of 1 MPa or 5 MPa, depending on the direction of the applied stress. After a month of incubation, normal human dermal fibroblasts (NHDFs) were seen growing on the scaffolds, which demonstrated that no deleterious effects were exerted by the MEW scaffolds constructed using FDM cPLA molds. The significant potential of our hybrid additive manufacturing approach to fabricate complex MEW scaffolds could be applied to a variety of tissue engineering applications, particularly in the field of vascularization.
Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption
Authors: Turczynowicz Aleksander , Jakubów Piotr , Niedźwiecka Karolina , Kondracka Julia , Pużyńska Weronika , Tałałaj Mariola , Guszczyn Tomasz , Grabala Paweł , Kowalczuk Oksana , Kocańda Szymon
Published: November 2023

Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine connection between OPRM1 and rs1205 CRP SNPs in pediatric patients postoperatively and pain intensity, the opioid dose needed to control pain after scoliosis correction, and other clinical aspects. Genotypes of rs1205 CRP and OPRM1 polymorphisms in a sample of 31 patients were specified, and statistical analysis was performed in terms of age, genotype frequency, pain assessment, sufentanil flow, post-anesthesia care unit stay, and the use of coanalgesics. The frequency of A/A and A/G genotypes in the OPRM1 gene was in line with 1000Genomes data for the European population. Patients from the AG group of OPRM1 SNP more frequently required coanalgesics for adequate pain control; however, it was of weak statistical significance. Other parameters measured in the study were not statistically significant in relation to OPRM1 and CRP polymorphisms. The effect of SNPs on postoperative pain management and opioid therapy in children was not confirmed by this study. An expansion of the study sample and other opioid-related SNPs is required.
The Role of Apolipoproteins in the Commonest Cancers: A Review
Authors: Darwish Nour M. , Al-Hail Mooza Kh. , Mohamed Youssef , Al Saady Rafif , Mohsen Sara , Zar Amna , Al-Mansoori Layla , Pedersen Shona
Published: November 2023

Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors.
AgNPs Embedded in Porous Polymeric Framework: A Reusable Catalytic System for the Synthesis of α-Alkylidene Cyclic Carbonates and Oxazolidinones via Chemical Fixation of CO2
Authors: Banerjee Bipasha , Chakrabortty Pekham , Haque Najirul , Ghosh Swarbhanu , Sarkar Mitali , Khan Aslam , Islam Sk. Manirul
Published: November 2023

Porous polymeric frameworks have received great interest over the past few years because of their nonstop growth as crystalline porous polymeric materials connected through covalent bonds and versatile utilities in diverse fields. The production of high-value organic compounds via sustainable and environment-friendly methods is an uphill struggle for researchers. The elegant strategy of using carbon dioxide as a C1 building block is an intriguing platform owing to its non-toxicity, easy accessibility, natural abundance, recyclability, non-flammability, and cheapness. Additionally, CO2 levels are regarded as the main contributor to the greenhouse effect (the most abundant greenhouse gas across the globe) and the aforementioned strategy needs to mitigate CO2 emissions. This present study describes the synthesis of silver nanoparticles (AgNPs) embedded in a porous polymeric framework, a reusable heterogeneous catalyst (recyclable over 5 times), TpMA (MC)@Ag. The synthesized catalyst is characterized by using FT-IR, PXRD, XPS, FE-SEM, TEM, EDAX, TGA DTA, and N2 sorption studies. Additionally, the catalysts can be easily recycled to generate the desired α-alkylidene cyclic carbonates and oxazolidinone compounds under solvent-free conditions. This research demonstrates the potential of nanoporous 2D porous polymeric framework-based materials in the area of catalysis, specially, in CO2 capture and chemical fixation. These findings offer a promising approach for the chemical fixation of CO2 into α-alkylidene cyclic carbonates and oxazolidinones from propargylic alcohols utilizing AgNPs embedded in a 2D catalyst, which functions as a potential heterogeneous catalyst under mild conditions (e.g., solvent-free approach).
An Exosome-Rich Conditioned Medium from Human Amniotic Membrane Stem Cells Facilitates Wound Healing via Increased Reepithelization, Collagen Synthesis, and Angiogenesis
Authors: Noh Chan Ho , Park Sangryong , Seong Hye-Rim , Lee Ah-young , Tsolmon Khan-Erdene , Geum Dongho , Hong Soon-Cheol , Kim Tae Myoung , Choi Ehn-Kyoung , Kim Yun-Bae
Published: November 2023

Tissue regeneration is an essential requirement for wound healing and recovery of organs’ function. It has been demonstrated that wound healing can be facilitated by activating paracrine signaling mediated by exosomes secreted from stem cells, since exosomes deliver many functional molecules including growth factors (GFs) and neurotrophic factors (NFs) effective for tissue regeneration. In this study, an exosome-rich conditioned medium (ERCM) was collected from human amniotic membrane stem cells (AMSCs) by cultivating the cells under a low oxygen tension (2% O2 and 5% CO2). The contents of GFs and NFs including keratinocyte growth factor, epidermal growth factor, fibroblast growth factor 1, transforming growth factor–β, and vascular endothelial growth factor responsible for skin regeneration were much higher (10–30 folds) in the ERCM than in normal conditioned medium (NCM). In was found that CM–DiI-labeled exosomes readily entered keratinocytes and fibroblasts, and that ERCM not only facilitated the proliferation of keratinocytes in normal condition, but also protected against H2O2 cytotoxicity. In cell-migration assay, the scratch wound in keratinocyte culture dish was rapidly closed by treatment with ERCM. Such wound-healing effects of ERCM were confirmed in a rat whole skin-excision model: i.e., the wound closure was significantly accelerated, remaining minimal crusts, by topical application of ERCM solution (4 × 109 exosome particles/100 μL) at 4-day intervals. In the wounded skin, the deposition of collagens was enhanced by treatment with ERCM, which was supported by the increased production of collagen-1 and collagen-3. In addition, enhanced angiogenesis in ERCM-treated wounds was confirmed by increased von Willebrand factor (vWF)-positive endothelial cells. The results indicate that ERCM from AMSCs with high concentrations of GFs and NFs improves wound healing through tissue regeneration not only by facilitating keratinocyte proliferation for skin repair, but also activating fibroblasts for extracellular matrix production, in addition to the regulation of angiogenesis and scar tissue formation.
Synergism between IL-33 and MRGPRX2/FcεRI Is Primarily Due to the Complementation of Signaling Modules, and Only Modestly Supplemented by Prolonged Activation of Selected Kinases
Authors: Franke Kristin , Li Zhuoran , Bal Gürkan , Zuberbier Torsten , Babina Magda
Published: November 2023

Skin mast cells (MCs) express high levels of MRGPRX2, FcεRI, and ST2, and vigorously respond to their ligands when triggered individually. IL-33/ST2 also potently synergizes with other receptors, but the molecular underpinnings are poorly understood. Human skin-derived MCs were stimulated via different receptors individually or jointly in the presence/absence of selective inhibitors. TNF was quantified by ELISA. Signaling cascades were studied by immunoblot. TNF was stimulated by FcεRI ≈ ST2 > MRGPRX2. Surprisingly, neither FcεRI nor MRGPRX2 stimulation elicited NF-κB activation (IκB degradation, p65 phosphorylation) in stark contrast to IL-33. Accordingly, TNF production did not depend on NF-κB in FcεRI- or MRGPRX2-stimulated MCs, but did well so downstream of ST2. Conversely, ERK1/2 and PI3K were the crucial modules upon FcεRI/MRGPRX2 stimulation, while p38 was key to the IL-33-elicited route. The different signaling prerequisites were mirrored by their activation patterns with potent pERK/pAKT after FcεRI/MRGPRX2, but preferential induction of pp38/NF-κB downstream of ST2. FcεRI/MRGPRX2 strongly synergized with IL-33, and some synergy was still observed upon inhibition of each module (ERK1/2, JNK, p38, PI3K, NF-κB). IL-33’s contribution to synergism was owed to p38 > JNK > NF-κB, while the partner receptor contributed through ERK > PI3K ≈ JNK. Concurrent IL-33 led to slightly prolonged pERK (downstream of MRGPRX2) or pAKT (activated by FcεRI), while the IL-33-elicited modules (pp38/NF-κB) remained unaffected by co-stimulation of FcεRI/MRGPRX2. Collectively, the strong synergistic activity of IL-33 primarily results from the complementation of highly distinct modules following co-activation of the partner receptor rather than by altered signal strength of the same modules.
Pediatric Anesthesia Providers’ Perspective on the Real-Life Implementation of the Philips Visual Patient Avatar: A Qualitative Study
Authors: Lunkiewicz Justyna , Fries Daniel , Milovanovic Petar , Noethiger Christoph B. , Tscholl David W. , Gasciauskaite Greta
Published: November 2023

The Philips Visual Patient Avatar represents an alternative method of patient monitoring that, according to computer-based simulation studies, enhances diagnostic accuracy and confidence and reduces workload. After its clinical integration, we assessed pediatric anesthesia providers’ perspectives on this technology. This is a single-center qualitative study, conducted at the University Hospital Zurich using in-depth individual interviews. We aimed to identify the advantages and limitations of the Visual Patient Avatar in pediatric anesthesia and to assess children’s and parents’ reactions from caregivers’ perspectives. Thematic analysis was used to identify the dominant themes. Fourteen members of the institution’s pediatric anesthesia team were interviewed. The most prevalent themes were children’s positive reactions towards the Visual Patient Avatar (92.9%) and enhanced speed in problem identification (71.4%). Additionally, 50% of participants reported finding the Visual Patient Avatar useful for diverting children’s attention during anesthesia induction, and 50% suggested that its vital sign thresholds should be adaptable for different age groups. The study revealed that the Visual Patient Avatar was recognized as a tool in pediatric anesthesia, enabling prompt identification of underlying issues and receiving positive feedback from both children and parents. The most commonly voiced wish for improvement in the study was the ability to customize the Visual Patient Avatar’s thresholds for different age groups.
Management of Pediatric Foreign Body Injuries during the COVID-19 Pandemic: Results of an International Survey
Authors: Ocagli Honoria , Azzolina Danila , Francavilla Andrea , Aydin Emrah , Baldas Solidea , Cocciaglia Alejandro , Rodriguez Hugo , Gregori Dario , Lorenzoni Giulia , Gruber Maayan ,   the COVID-19-Susy Group
Published: November 2023

The COVID-19 pandemic has had direct and indirect effects on daily life. In hospitals, the impact of the pandemic was observed in the diagnostic and therapeutic workflow. In this work, we explored potential changes in activities related to the treatment of foreign body injuries (FBIs) in children and the behavioral habits of physicians during the first wave of the pandemic. An online survey was conducted among physicians of the Susy Safe network. The survey comprised items related to respondent information, reference center characteristics, the treatment of FBIs during the COVID-19 pandemic, and a modified COVID-19 Anxiety Scale (CAS). The survey was distributed among the Susy Safe project international network surveillance registry for FBIs. A total of 58 physicians responded to the survey, including 18 (32%) from Europe and 16 (28%) from South America. The respondents indicated that the estimated number of aspirated foreign bodies during the pandemic was lower than or the same as that before the pandemic (43, 74%), and the same was observed for ingested foreign bodies (43, 74%). In univariable logistic regression, no single predictor was associated with a delay in routine care for children or an increasing tendency of medical personnel to avoid procedures. The workflow of physicians involved in the management of FBIs in children has not changed drastically during the COVID-19 pandemic, especially in emergency departments.
Treatment following Triple-AAV Delivery in Mature Murine Model of Human CDH23-Associated Hearing Loss
Authors: Yoshimura Hidekane , Yokota Shu , Takumi Yutaka
Published: November 2023

This study aimed to investigate the transduction efficiency of triple adeno-associated virus (AAV) vectors in the cochleae of adult mice, focusing on large-gene-associated hearing loss (HL). Additionally, we sought to evaluate the feasibility of cochlear gene therapy in a mouse model of human CDH23-mediated HL using the triple AAV approach. To create a reporter protein, we fused EGFP to mCherry, which was then divided into three parts, each packaged in a separate AAV2/2 vector. Four weeks after co-injecting the triple AAV vectors into 4–5-week-old mice, we assessed transduction efficiency. We found that up to 5.9% of inner hair cells were positive for both EGFP and mCherry. Subsequently, we developed triple Cdh23 AAV vectors for therapeutic purposes. After administering these vectors to 4- to 5-week-old C57/BL6 mice, we conducted auditory tests and immunohistochemistry studies over a period of 60 weeks. Co-injecting triple Cdh23-AAVs did not alter auditory function or lead to hair cell degeneration. In conclusion, this study confirms the feasibility of the triple-AAV approach for cochlear gene delivery. While this strategy did not produce any treatment effects, our findings suggest that large deafness genes could be potential future targets for cochlear gene therapy.
Enhanced Corrosion Resistance of TiZrN-Coated Additively Manufactured 8620 Low-Alloy Steel in Nitrate Salt Solution and Salt Bath
Authors: Sabuz Ezazul Haque , Maruf Mahbub Alam , Haider Waseem , Shabib Ishraq
Published: November 2023

In this study, corrosion resistance of TiZrN-coated additively manufactured (3D-printed) 8620 steel has been separately studied in a 60–40 wt% NaNO3 + KNO3 molten salt and in an aqueous nitrate salt environment. Microstructural characterization of the as-built bare 3D-printed 8620 sample revealed martensitic microstructures. High-temperature corrosion analysis in molten nitrate salt revealed improved film stability and corrosion resistance of the coating. The coated 3D-printed sample showed no scale of corrosion products, whereas the bare 3D-printed sample exhibited a layer of corrosion products of 2.62 ± 0.24 µm thickness. Potentiodynamic polarization and electrochemical impedance spectroscopy tests in aqueous nitrate salts at room temperature exhibited an ~8-fold decrease in corrosion current density and a ~7-fold increase in charge transfer resistance, indicating enhanced corrosion resistance of the coated 8620. The coated wrought 8620 showed comparable corrosion resistance to that of the coated 3D-printed sample. However, in aqueous solution, the bare 3D-printed sample exhibited localized corrosion, whereas the bare wrought revealed uniform corrosion on the surface.
Optimizing Intrusion Detection Systems in Three Phases on the CSE-CIC-IDS-2018 Dataset
Authors: Songma Surasit , Sathuphan Theera , Pamutha Thanakorn
Published: November 2023

This article examines intrusion detection systems in depth using the CSE-CIC-IDS-2018 dataset. The investigation is divided into three stages: to begin, data cleaning, exploratory data analysis, and data normalization procedures (min-max and Z-score) are used to prepare data for use with various classifiers; second, in order to improve processing speed and reduce model complexity, a combination of principal component analysis (PCA) and random forest (RF) is used to reduce non-significant features by comparing them to the full dataset; finally, machine learning methods (XGBoost, CART, DT, KNN, MLP, RF, LR, and Bayes) are applied to specific features and preprocessing procedures, with the XGBoost, DT, and RF models outperforming the others in terms of both ROC values and CPU runtime. The evaluation concludes with the discovery of an optimal set, which includes PCA and RF feature selection.
Biomechanical Efficacy of Three Methods for the Fixation of Posterior Malleolar Fractures: A Three-Dimensional Finite Element Study
Authors: Giordano Vincenzo , Babinski Márcio Antônio , Freitas Anderson , Pires Robinson Esteves , Souza Felipe Serrão de , Faria Luiz Paulo Giorgetta de , Labronici Pedro José , Godoy-Santos Alexandre
Published: November 2023

Introduction: We investigated the biomechanical behaviour of different fixations of the tibial posterior malleolus (TPM), simulating distinct situations of involvement of the tibiotalar articular surface (TTAS) through a finite element model (FEM). Material and methods: A 3D computer-aided design model of the left ankle was obtained. The materials used were divided according to their characteristics into ductile and non-ductile, and all materials were assumed to be linear elastic, isotropic, and homogenous. Three different fracture lines of the TPM were defined, with sagittal angles of 10°, 25°, and 45°. For biomechanical comparison, different constructions using a trans-syndesmotic screw (TSS) only (Group T), a one-third tubular plate only with (Group PT) and without (Group PS) a TSS, and a locked compression plate with (Group LCPT) and without (Group LCPS) a TSS were tested. FEM was used to simulate the boundary conditions of vertical loading. Load application regions were selected in the direction of the 700 N Z-axis, 90% on the tibia and 10% on the fibula. Data on the displacement and stress in the FEM were collected, including the total principal maximum (MaxT) and total principal minimum (MinT) for non-ductile materials, total displacement (desT), localized displacement at the fragment (desL), localized displacement at syndesmosis (desS), and Von Mises equivalent stress for ductile materials. The data were analysed using ANOVA and multiple comparison LSD tests were used. Results: For TPM fractures with sagittal angles 10° and 25°, desL in the PT and LCP groups was significantly lower, as well as Von Mises stress in Group LCPT in 10°, and PT and LCPT groups in 25°. For TPM fractures with a sagittal angle of 45°, desL in the LCP group and Von Mises stress in Group LCPS and LCPT were significantly lower. We found that any TPM fracture may indicate instability of the distal tibiofibular syndesmosis, even when the fragment is small. Conclusion: Our study showed that in fragments involving 10% of the TTAS, the use of a TSS is sufficient, but when the involvement is greater than 25% of the TTAS, either a non-locked or locked plate must be used to buttress the TPM. In posterior fragments affecting 45% or more of the TTAS, the use of a locking plate is recommended.
Establishing Reference Intervals for Normal Fetal Lung Biological Parameters at 21–40 Weeks of Gestation in the Chinese Population: A Cross-Sectional Study
Authors: Xia Taihui , Song Shijing , Wang Li , Sun Lijuan , Wang Jingjing , Wu Qingqing
Published: November 2023

(1) Background: There is no reliable way to assess antenatal fetal pulmonary hypoplasia; however, the biological parameters of the fetal lung can help in evaluating fetal lung development. This study aimed to establish the reference intervals for normal fetal lung biological parameters at 21–40 weeks among the Chinese population. (2) Methods: This was a cross-sectional study of Chinese groups, and included a total of 1388 normal single pregnant women at 21–40 weeks’ gestation. We selected 2134 images of a standard four-chamber view (4CV). ImageJ software (Release 2.14.0) was used to measure the left and right lung areas using a manual tracing method; the elliptic function key was used to measure the fetal thoracic circumference (TC), thoracic area (TA), head circumference (HC), heart area (HA), and abdominal circumference (AC). Based on the above measurements, the following parameters were calculated: lung area to head circumference ratio (LHR), total lung area (TLA), TLA/Weight (mm2/g), cardiothoracic ratio (CTR), lung–thoracic area ratio (TLA/TA), lung–heart area ratio (TLA/HA), TC/AC, and TC/HC. (3) Results: The left and right lung areas and LHRs positively correlated with gestational age (R2 = 0.85, 0.88, 0.66, 0.71, p < 0.001). From 21–40 weeks, the left and right lung areas and TLA increased by about 3.33 times, 3.16 times, and 3.22 times, respectively. The means of left and right LHRs increased by about 1.94 times and 1.84 times, respectively. TLA/Weight (mm2/g) was weakly correlated with gestational age, while CTR, TLA/TA, TLA/HA, TC/AC, and TC/HC had no significant correlation with gestational age. There was no statistically significant difference in fetal lung parameters between different genders of newborns, p > 0.05. (4) Conclusions: Our study establishes the reference intervals for normal Chinese fetal lung biological parameters at 21–40 weeks. Moreover, the reference intervals apply to fetuses of different genders. This paper can provide a reference for the prenatal non-invasive assessment of fetal pulmonary hypoplasia.
Investigating the Emotional Experiences of Sophomore Students in English Language Education in Eritrea from an Ecological Perspective
Authors: Tewelde Mussie , Moate Josephine , Posti-Ahokas Hanna
Published: November 2023

Although the mother tongue policy in Eritrea aims to promote positive language learning trajectories for students, the transition to English as a medium of instruction from the start of junior education remains emotionally demanding for students until the end of tertiary education. Through in-depth qualitative interviews, this study investigates the emotional experiences of sophomore students in English language education (ELE) and seeks the sources of emotions that facilitate or debilitate English language development. Drawing on an ecological perspective, the findings highlight how students’ positive, ambivalent, and negative emotions were evoked by the conditions that informed their identities and ideal selves. This study aims to understand what activates students’ emotions and informs their visualisation of their ideal selves within the ecosystem of English language education. Overall, this study highlights the importance of creating a network of supportive emotional affordances, despite the constraints of the ecosystem, to enhance students’ emotional mindfulness to transform negative emotions into positive emotional experiences to attain their ideal selves.
Fast Prediction Method of Combustion Chamber Parameters Based on Artificial Neural Network
Authors: Shao Chenhuzhe , Liu Yue , Zhang Zhedian , Lei Fulin , Fu Jinglun
Published: November 2023

Gas turbines are widely used in industry, and the combustion chamber, compressor, and turbine are known as their three important components. In the design process of the combustion chamber, computational fluid dynamics simulation takes up a lot of time. In order to accelerate the design speed of the combustion chamber, this article proposes a combustion chamber design method that combines an artificial neural network (ANN) and computational fluid dynamics (CFD). CFD results are used as raw data to establish a fast prediction model using ANN and eXtreme Gradient Boosting (XGBoost). The results show that the mean squared error (MSE) of the ANN is 0.0019, and the MSE of XGBoost is 0.0021, so the ANN’s prediction performance is slightly better. This fast prediction method combines CFD and the ANN, which can greatly shorten CFD calculation time, improve the efficiency of gas turbine combustion chamber design, and provide the possibility of achieving digital twins of gas turbine combustion chambers.
The Energy Retrofit Impact in Public Buildings: A Numerical Cross-Check Supported by Real Consumption Data
Authors: Ballerini Vincenzo , Lubowicka Bernadetta , Valdiserri Paolo , Krawczyk Dorota Anna , Sadowska Beata , Kłopotowski Maciej , di Schio Eugenia Rossi
Published: November 2023

In the framework of reducing carbon dioxide emissions and energy consumption, the energy retrofit of existing buildings plays a significant role and is often supported by numerical analyses of the planned activities and expected results. This study analyses a public building (a kindergarten) located in Bialystok (Poland) and aims to determine the building’s energy performance prior to and after thermal modernization. The building was examined by employing two different software packages, Audytor OZC 7.0 Pro and Trnsys 18. The thermal efficiency improvement applied to the renovated building in Bialystok was also analyzed by virtually locating the building in Bologna (Italy). Moreover, a comfort analysis focused on the classrooms of the kindergarten was carried out employing Trnsys. As a novelty, in the analysis, particular attention is paid to ventilation losses and to the influence of envelope elements properties on the building energy demand. The results arising from analyses were compared to real consumption data for the heating season. The results obtained from the two software programs display excellent agreement, and they also match the real consumption data if the heating demand is considered, while some differences arise when the cooling demand is considered.
Zero-Voltage-Switching Analysis Model of the Triple-Active-Bridge Converter
Authors: Byun Hyung-Jun , Park Jung-Min , Yi Junsin , Won Chung-Yuen
Published: November 2023

This study aims to analyze the zero-voltage-switching (ZVS) region of a Triple-Active-Bridge (TAB) converter with five degrees of freedom. A TAB converter is an isolated converter derived from a dual-active-bridge (DAB) converter and composed of three full bridges (FBs) coupled to three winding transformers. To reduce the switching loss of the 12 active switches that compose 3 FBs, the ZVS operation is essential. However, owing to the numerous operation modes derived by five-phase shift ratios, ZVS analysis is complicated, particularly in the time domain. Therefore, this study presents the ZVS analysis model of the TAB converter based on the generalized harmonic approximation (GHA). Through the GHA of a TAB converter, the proposed model consists of unified formulas applicable to all operating ranges of the converter. Unified formulas consider all parameters, such as series inductance, port voltage, parasitic capacitance, transformer voltage, and turn ratio. In the proposed model, the ZVS area is confirmed using five-phase ratios with voltage modulation ratios as variables and verified using MATLAB and experiments.
Municipal Sustainability and Climate Planning: A Study of 38 Canadian Local Governments’ Plans and Reports
Authors: Feor Leah , Murray Dan , Folger-Laronde Zachary , Clarke Amelia
Published: November 2023

Even with the benefits of sustainability and climate change reporting, there is limited information on how municipalities are reporting on performance for external stakeholders in comparison with private sector organizations. The purpose of this research was to gain an understanding of the current state of sustainability and climate change reporting at the local level and to investigate the extent to which municipalities across Ontario, Canada, report. We used content analysis to identify the presence or non-presence of information on the websites of 38 municipalities and analyzed the results using descriptive statistics. Our analysis showed that the sample municipalities were not widely reporting on sustainability or climate change performance. Also, we identified a gap between the number of plans and reports produced by sample municipalities, with the latter being less common, indicating a need for an improved evaluation of plan implementation. Further, we found that a provincial regulation that required municipalities to make their energy conservation and demand management plans public did not guarantee publication of the plan on a municipality’s website. This study contributes to the growing field of sustainability and climate change planning and reporting by local governments and offers empirical evidence specific to Ontario, Canada.
Forest Functioning under Climate Warming and Future Perspectives on Forest Disturbances
Authors: Mary Petritan Any , Beloiu Schwenke Mirela
Published: November 2023

The Special Issue “Impact of climate warming and disturbances on forest ecosystems” underscores the critical importance of understanding how forests respond to these environmental challenges and the legacy of past management practices. Forest ecosystems are facing significant challenges due to ongoing climate change, characterized by rising temperatures and increased frequency of extreme events. The rapid pace of climate change is altering disturbance patterns and the adaptability of forests, which have a direct impact on ecosystem services that contribute to human well-being. This Special Issue features 11 research papers from nine countries. Some key outputs from these research papers include evidence on how climate change is already impacting forest ecosystems. For instance, the climatic envelope of many forest species has shifted due to global warming, making species more vulnerable, especially in lower elevations and at the edges of their distribution. Urgent adaptive measures in forest management are necessary to address this challenge. Climate change also affects vegetation phenology, tree growth, stand productivity, reproduction rates, and stand regeneration. Remote sensing data and ecological modeling techniques play a crucial role in monitoring and understanding these changes, especially in remote regions where field measurements are limited. The rising frequency and intensity of extreme events like droughts, windstorms, and forest fires require enhanced prediction and automatic monitoring. Leveraging machine learning tools and remote sensing data is imperative. This Special Issue provides insights into the intricate relationships among forests, climate change, and human interventions. We provide further research recommendations for the quantification and automated monitoring of forest fires and the management of forests to better withstand storms and increase their resilience to climate change.
Monitoring the Condition of Wetlands in the Syr Darya Floodplain—How Healthy Are the Tugai Forests in Kazakhstan?
Authors: Schulz Christian , Kleinschmit Birgit
Published: November 2023

Tugai wetlands, including the forests of Populus euphratica Oliv. and P. pruinosa Schrenk, are major biodiversity hotspots within semi-arid and arid ecozones. However, for over a century, Central Asian river systems have been severely affected by dam regulation, water withdrawals for large-scale irrigated agriculture, and deforestation. To support sustainable use and protection of this threatened forest type, we provide information on the distribution and degradation status of Tugai wetlands in the Syr Darya floodplain using Normalized Difference Vegetation Index (NDVI) time series from Landsat 7 and Moderate Resolution Imaging Spectroradiometer (MODIS). An accuracy assessment confirmed the validity of the MODIS-based wetland map, with an overall accuracy of 78.6%. This was considerably better than the Landsat product, mainly due to the greater temporal frequency of the MODIS time series. We further calculated trends and breakpoints between 2001 and 2016 using the BFAST algorithm. We found negative trends for nearly a third of the wetlands. Breakpoint detection showed major stress events in the years 2001, 2009, and 2016. Our study revealed the temporal and spatial distribution and vitality of an endangered forest ecosystem that has rarely been studied thus far. Climate change may accelerate the destabilization of the Tugai forests at the Syr Darya floodplain.
Remote Sensing Indicators of Spongy Moth (Lymantria dispar L.) Damage to Birch Stands in Western Siberia
Authors: Kovalev Anton , Soukhovolsky Vladislav , Tarasova Olga , Akhanaev Yuriy , Martemyanov Vyacheslav
Published: November 2023

The goal of this study is to detect indicators of damage to birch stands in western Siberia by spongy moth (Lymantria dispar L.) using remote sensing methods. The need for such indicators is due to the fact that the size of the study area is about 1 million square kilometers, and ground methods are too laborintensive. It is crucial for these indicators to differentiate the effects of insects from other destructive factors like fires and droughts. During the 2021–2022 fieldwork, we identified 18 areas for trial (intensive damage due to caterpillars) and control. For each area, we obtained seasonal time-series data of vegetation index NDVI mean values within its boundaries. We acquired the data from a Sentinel-2 satellite with a spatial resolution of 10 m. Relative reduction indices of NDVI during the season were introduced for pairs of damaged–control plots. We also considered the effect of foliage regeneration on damaged trees. The obtained indicators demonstrate increased analytical significance in identifying areas affected by pests compared to the simple reduction in vegetative indices.
Phenology of Vegetation in Arid Northwest China Based on Sun-Induced Chlorophyll Fluorescence
Authors: Chen Zhizhong , Zan Mei , Kong Jingjing , Yang Shunfa , Xue Cong
Published: November 2023

The accurate monitoring of vegetation phenology is critical for carbon sequestration and sink enhancement. Vegetation phenology in arid zones is more sensitive to climate responses; therefore, it is important to conduct research on phenology in arid zones in response to global climate change. This study compared the applicability of the enhanced vegetation index (EVI), which is superior in arid zones, and global solar-induced chlorophyll fluorescence (GOSIF), which has a high spatial resolution, in extracting vegetation phenology in arid zones, and explored the mechanism of the differences in the effects of environmental factors on the phenology of different vegetation types. Therefore, this study employed a global solar-induced chlorophyll fluorescence (GOSIF) dataset to determine the start and end of the vegetation growth season (SOSSIF and EOSSIF, respectively) in the arid zone of Northwest China from 2001 to 2019. The results were compared with those from the EVI-based MODIS climate product MCD12Q2 (SOSEVI and EOSEVI). Variations in the sensitivity of these climatic datasets concerning temperature, precipitation, and standardised precipitation evapotranspiration index (SPEI) were assessed through partial correlation analysis. Results: Compared to the MCD12Q2 climatic products, SOSSIF and EOSSIF closely matched the observed climate data in the study area. Spring onset was delayed at higher altitudes and latitudes, and the end of the growing season occurred earlier in these areas. Both SOSSIF and EOSSIF significantly advanced from 2001 to 2019 (trend degrees −0.22 and −0.48, respectively). Spring vegetation phenology was chiefly influenced by precipitation while autumn vegetation phenology was driven by both precipitation and SPEI. GOSIF-based climate data provides a more accurate representation of vegetation phenology compared to traditional vegetation indices. The findings of this study contribute to a deeper understanding of the potential ability of EVI and SIF to reveal the influence of vegetation phenology on the carbon cycle.
Mating Behavior and Sexual Selection in Monochamus saltuarius (Gebler)
Authors: Zhang Chuchu , Wu Hao , Hou Zehai , Zong Shixiang
Published: November 2023

The Sakhalin pine sawyer Monochamus saltuarius (Gebler) (Coleoptera: Cerambycidae) is a new vector of pine wood nematode in China, which has caused huge economic losses in the forestry industry. The mating process of M. saltuarius has been described in detail. However, mate choice and sexual selection in this species are not fully understood. In this study, we quantitatively evaluated the characteristics associated with contact between the sexes in mating and inferred the sex-specific characteristics under selection. We detected positive correlations between the morphological characteristics of females and males. Most female traits and all male traits differed significantly between mated and unmated individuals. The results of this study provide evidence for the selection of the mating preferences in M. saltuarius.