bluuebunny/crossref_metadata_2025 huggingface dataset:
Entrepreneurs’ Social Network and Corporate Risk Contagion: A Dynamic Evaluation and Simulation Approach
Authors: Yang Yang , Qian Qian , Li Zheng
Published: December 2020

Interactions of entrepreneurs through social networks provide an available path for corporate risk contagions. However, the issue how entrepreneurs’ social networks influence on corporate risk contagion is still received limited attention from scholars. In this study, a framework is proposed to describe entrepreneurs’ interaction and corporate value creation. The main results of multiagent simulations indicate the following. First, either weak ties or strong connections of social networks can enhance density of corporate risk contagion. However, only strong connections can be moderated by entrepreneurs’ risk preference. Second, weak ties improve risk exposure of individual corporations, while strong connections may probably decrease systematical risk of the market. Third, weak ties are important for mature corporations to achieve business success. However, for startups, strong connections are more valuable to maintain. The findings of this study not only provide theoretical support from some widely accepted economic phenomenon but also provide explanations for conflicting results from some previous literatures.
How to Achieve Efficiency and Accuracy in Discrete Element Simulation of Asphalt Mixture: A DRF‐Based Equivalent Model for Asphalt Sand Mortar
Authors: Liu Yu , Su Peifeng , Li Miaomiao , Yao Hui , Liu Junfu , Xu Mei , Zhou Xiaodong , You Zhanping
Published: December 2020

The clump‐based discrete element model is one of the asphalt mixture simulation methods, which has the potential to not only predict mixture performance but also simulate particle movement during compaction, transporting, and other situations. However, modelling of asphalt sand mortar in this method remains to be a problem due to computing capacity. Larger‐sized balls (generally 2.0–2.36 mm) were usually used to model the smaller particles and asphalt binder, but this replacement may result in the mixture’s unrealistic volumetric features. More specifically, replacing original elements with equal volume but larger size particles will increase in buck volume and then different particle contacting states. The major objective of this research is to provide a solution to the dilemma situation through an improved equivalent model of the smaller particles and asphalt binders. The key parameter of the equivalent model is the diameter reduction factor (DRF), which was proposed in this research to minimize the effects of asphalt mortar’s particle replacement modelling. To determine DRF, the DEM‐based analysis was conducted to evaluate several mixture features, including element overlap ratio, ball‐wall contact number, and the average wall stress. Through this study, it was observed that when the original glued ball diameters are ranging from 2.00 mm and 2.36 mm, the diameter reduction factor changes from 0.82 to 0.86 for AC mixtures and 0.80 to 0.84 for SMA mixtures. The modelling method presented in this research is suitable not only for asphalt mixtures but also for the other particulate mix with multisize particles.
Estimation of the Resistivity Index via Nuclear Magnetic Resonance Log Data Based on Fractal Theory
Authors: Feng Cheng , Han Chuang , Duan Wenxing , Wang Wei , Zhong Yuntao , Feng Ziyan , Zhang Ning
Published: December 2020

The resistivity index is an important parameter for determining the rock saturation index. However, the saturation index changes greatly in unconventional reservoirs, which leads to oil saturation estimation with great difficulty. Hence, we try to establish the relationship between the resistivity index and log data. Firstly, a novel model of estimating the resistivity index with

T

2

time was derived based on fractal theory, the relationship between nuclear magnetic resonance (NMR)

T

2

spectrum and capillary pressure curve (

T

2

-

P

c

), and Archie formula. It regards the logarithm of the resistivity index as the dependent variable, with

T

2

time and

T

2

time when water saturation is 100% as the independent variables. Second, 17 cores were drilled, and

T

2

spectrum and the relationship between the resistivity index and water saturation (

I

r

-

S

w

) were jointly measured. Next, the experimental results were substituted into the established model to get the model parameters via the multivariate statistics regression method. Then, the experimental data engaged and not engaged in modeling were used to test the established model. The average relative errors of estimated resistivity indices and experimental results are smaller than 8%, and those of the regressed saturation index are smaller than 5%. Finally, the established model was applied in log data processing and interpretation with good effects. It thus proves that the method of the estimating resistivity index with

T

2

time is reliable, which provides a novel solution for determining rock electrical parameter of unconventional reservoirs.
Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin
Authors: Wagner Jessica , Wickman Elizabeth , Shaw Timothy I. , Anido Alejandro Allo , Langfitt Deanna , Zhang Jinghui , Porter Shaina N. , Pruett-Miller Shondra M. , Tillman Heather , Krenciute Giedre , Gottschalk Stephen
Published: December 2020

Chimeric antigen receptor (CAR) T-cell therapy has had limited success in early-phase clinical studies for solid tumors. Lack of efficacy is most likely multifactorial, including a limited array of targetable antigens. We reasoned that targeting the cancer-specific extra domain B (EDB) splice variant of fibronectin might overcome this limitation because it is abundantly secreted by cancer cells and adheres to their cell surface. In vitro, EDB-CAR T cells recognized and killed EDB-positive tumor cells. In vivo, 1 × 106 EDB-CAR T cells had potent antitumor activity in both subcutaneous and systemic tumor xenograft models, resulting in a significant survival advantage in comparison with control mice. EDB-CAR T cells also targeted the tumor vasculature, as judged by IHC and imaging, and their antivascular activity was dependent on the secretion of EDB by tumor cells. Thus, targeting tumor-specific splice variants such as EDB with CAR T cells is feasible and has the potential to improve the efficacy of CAR T-cell therapy.
Kindlin3-Dependent CD11b/CD18-Integrin Activation Is Required for Potentiation of Neutrophil Cytotoxicity by CD47–SIRPα Checkpoint Disruption
Authors: Bouti Panagiota , Zhao Xi Wen , Verkuijlen Paul J.J.H. , Tool Anton T.J. , van Houdt Michel , Köker Nezihe , Köker Mustafa Yavuz , Keskin Ozlem , Akbayram Sinan , van Bruggen Robin , Kuijpers Taco W. , Matlung Hanke L. , van den Berg Timo K.
Published: December 2020

The CD47–signal regulatory protein-alpha (SIRPα) immune checkpoint constitutes a therapeutic target in cancer, and initial clinical studies using inhibitors of CD47–SIRPα interactions in combination with tumor-targeting antibodies show promising results. Blockade of CD47–SIRPα interaction can promote neutrophil antibody-dependent cellular cytotoxicity (ADCC) toward antibody-opsonized targets. Neutrophils induce killing of antibody-opsonized tumor cells by a process identified as trogoptosis, a necrotic/lytic type of cancer cell death that involves trogocytosis, the antibody-mediated endocytic acquisition of cancer membrane fragments by neutrophils. Both trogocytosis and killing strictly depend on CD11b/CD18-(Mac-1)–mediated neutrophil–cancer cell conjugate formation, but the mechanism by which CD47–SIRPα checkpoint disruption promotes cytotoxicity has remained elusive. Here, by using neutrophils from patients with leukocyte adhesion deficiency type III carrying FERMT3 gene mutations, hence lacking the integrin-associated protein kindlin3, we demonstrated that CD47–SIRPα signaling controlled the inside-out activation of the neutrophil CD11b/CD18-integrin and cytotoxic synapse formation in a kindlin3-dependent fashion. Our findings also revealed a role for kindlin3 in trogocytosis and an absolute requirement in the killing process, which involved direct interactions between kindlin3 and CD18 integrin. Collectively, these results identified a dual role for kindlin3 in neutrophil ADCC and provide mechanistic insights into the way neutrophil cytotoxicity is governed by CD47–SIRPα interactions.
ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity
Authors: Haines Brian B. , Denslow Agnieszka , Grzesik Peter , Lee Jennifer S. , Farkaly Terry , Hewett Jacqueline , Wambua Daniel , Kong Lingxin , Behera Prajna , Jacques Judith , Goshert Caitlin , Ball Michael , Colthart Allison , Finer Mitchel H. , Hayes Melissa W. , Feau Sonia , Kennedy Edward M. , Lerner Lorena , Quéva Christophe
Published: December 2020

ONCR-177 is an engineered recombinant oncolytic herpes simplex virus (HSV) with complementary safety mechanisms, including tissue-specific miRNA attenuation and mutant UL37 to inhibit replication, neuropathic activity, and latency in normal cells. ONCR-177 is armed with five transgenes for IL12, FLT3LG (extracellular domain), CCL4, and antagonists to immune checkpoints PD-1 and CTLA-4. In vitro assays demonstrated that targeted miRNAs could efficiently suppress ONCR-177 replication and transgene expression, as could the HSV-1 standard-of-care therapy acyclovir. Although ONCR-177 was oncolytic across a panel of human cancer cell lines, including in the presence of type I IFN, replication was suppressed in human pluripotent stem cell–derived neurons, cardiomyocytes, and hepatocytes. Dendritic cells activated with ONCR-177 tumor lysates efficiently stimulated tumor antigen–specific CD8+ T-cell responses. In vivo, biodistribution analyses suggested that viral copy number and transgene expression peaked approximately 24 to 72 hours after injection and remained primarily within the injected tumor. Intratumoral administration of ONCR-177 mouse surrogate virus, mONCR-171, was efficacious across a panel of syngeneic bilateral mouse tumor models, resulting in partial or complete tumor regressions that translated into significant survival benefits and to the elicitation of a protective memory response. Antitumor effects correlated with local and distant intratumoral infiltration of several immune effector cell types, consistent with the proposed functions of the transgenes. The addition of systemic anti–PD-1 augmented the efficacy of mONCR-171, particularly for abscopal tumors. Based in part upon these preclinical results, ONCR-177 is being evaluated in patients with metastatic cancer (ONCR-177-101, NCT04348916).
Is it Possible to Connect Recognition with a Post-Identitarian Notion of Solidarity?
Authors: Fischer Mariana
Published: December 2020

This article intends to confront the perspectives of Axel Honneth and Judith Butler on solidarity. Honneth emphasizes the role of identities and a notion of solidarity connected to cultural backgrounds, shared narratives and world images. Butler, on the other hand, fears that this form of solidarity, based on similitudes, might lead to social narcissism. She believes that it is possible to foster another kind of solidarity, one based on our shared vulnerability and on experiences that can make us recognize that we are not identical to ourselves. Investigating the tensions between these two very dissimilar points of view will help to explore possible connections between post-identitarian forms of solidarity and affects such as desire and mourning, which are frequently at stake in social struggles.
Intellectual Innovations in Georgia (11th-9th Centuries BC)
Authors: Licheli Vakhtang
Published: December 2020

The multilayer archaeological site Grakliani hill is located in one of the main contact zones of Transcaucasia. It shows a very intensive level of communication with other cultures from the 2nd millenium BC till the 3rd century BC and a high level of development of Kartli (Iberia Caucasica) society. Two inscriptions made in unknown script (probably a local version of Aramaic script) were discovered in a shrine of the 11th-9th centuries BC. A group of weights and tokens, also of the 11th-9th centuries BC was discovered in the excavations of Grakliani Hill and the satellite site of Tsina Gora. The Achaemenid period remains are also of special interest, including Greek style architecture details.
Investigating the Internationalisation of State Nobilities: A Reflexive Return to Double Game Strategies
Authors: Bigo Didier , Cohen Antonin , _ _
Published: December 2020

In the second part of this interview, Yves Dezalay – an Emeritus cnrs researcher who spent much of his professional career at the Centre of European Sociology in Paris – takes us even deeper into his trajectory as a scholar. In situating the institutional-intellectual spaces in which he circulated, Dezalay brings to life the inter/intra-disciplinary boundaries he regularly crossed and even forced open in his quest to understand the complexity of interconnections between the national and the international, the professional and the political, as well as the law and the state in overlapping processes of globalization. Speaking about his long-term collaboration with professor of law Bryant Garth, Dezalay also elaborates a collaborationist methodology of transversal, multi-sited research.
Italian Perspectives on Pandemic Responses: Tracing Early Critiques from Europe’s First Lockdown
Authors: Fumagalli Andrea , Gandini Sara , Morini Cristina
Published: December 2020

This paper is a translation of three early critiques of the responses of the Covid-19 pandemic in Italy, each addressing a unique facet and different perspective of Europe’s first lockdown. Through bringing together these memorial traces, the article captures the heterogeneity of discussions taking place on the left at the very beginning of the pandemic, destabilizing a totalizing framing of Covid responses through simple binaries such as health vs economics or individual rights vs the collective good. Crisitina Morini addresses the ambivalences around the term ‘care’ (in Italian meaning both ‘attention’ and ‘cure’). Grounded in feminist economics, she argues for the establishment of a self-determination income envisioned as an unconditional and universal income, not linked to working positions. Sara Gandini ponders the possibility of turning anger into a political force and questions what forms this could take. Highlighting the problems related to turning a public health issue into one of national security, Gandini probes the politics of acceptability around Covid-related deaths against non-Covid related deaths, particularly deaths precisely exacerbated by confinement strategies. She speaks also of the silencing and policing of dissent when one tries to raise such issues in the public space. Lastly, Andrea Fumagalli uses the idea of crisis as an opportunity to rethink social and economic issues. These include readjusting the balance between private and public healthcare, (especially as Covid treatments are not very profitable), the implementation of a major European investment plan relating to social infrastructure and the environment, which will relaunch the European economy. Though these critiques were formulated at the start of the pandemic. many of the arguments and questions the authors asked themselves at the time remain highly topical: the role of welfare and income, the regulatory devices (including gender) that risk passing using the fight against the pandemic; all of which are central to maintaining a lucidity of analysis and to be resistant witnesses, politicizing anger to turn it into an agency that takes advantage of this difficult experience to build a slightly better world.
Mesoscale Prediction in the Antarctic Using Cycled Ensemble Data Assimilation
Authors: Riedel Christopher P. , Cavallo Steven M. , Parsons David B.
Published: December 2020

Due in part to sparse conventional observation coverage in the Antarctic region, atmospheric studies in this part of the globe often rely more heavily on numerical models. Model representation of atmospheric processes in the Antarctic remains inferior to representation in the Northern Hemisphere midlatitudes. Poor representation may be related to inaccurate model analyses that do not optimally utilize the limited observation network. Here, the ensemble Kalman filter (EnKF) data assimilation (DA) technique is employed in lieu of variational DA techniques to investigate impacts on model analysis accuracy. This DA technique [provided by the Data Assimilation Research Testbed (DART)] is coupled with a polar-modified, mesoscale numerical model that together compose Antarctic-DART (A-DART). A-DART is cycled with DA and run over a 1-month period, assimilating only conventional observations. Results show relatively good agreement between A-DART and observations. Comparison with radiosonde temperature and geostationary satellite wind observations shows large differences between RMSE and ensemble spread in the upper troposphere. The analysis increment shows large values in the eastern Atlantic–western Indian Oceans associated with geostationary satellite wind observations. Further evaluation determines that geostationary satellite wind observations may be biased in this region. Overall, this baseline demonstration of ensemble-based modeling applied in the Antarctic produced short-term forecasts that were competitive with two operational modeling systems while assimilating on the O(106) fewer observations. A-DART is capable of assimilating additional observations for a variety of applications. This study highlights the capability of applying this ensemble-based DA technique for process and forecast studies in an observation-sparse region.
Elucidating the Relationship Between Insomnia, Sex, and Cardiovascular Disease
Authors: Leeds Rebecca , Shechter Ari , Alcantara Carmela , Aggarwal Brooke , Usseglio John , Abdalla Marwah , Moise Nathalie
Published: December 2020

Sex differences in cardiovascular disease (CVD) mortality have been attributed to differences in pathophysiology between men and women and to disparities in CVD management that disproportionately affect women compared to men. Similarly, there has been investigation of differences in the prevalence and presentation of insomnia attributable to sex. Few studies have examined how sex and insomnia interact to influence CVD outcomes, however. In this review, we summarize the literature on sex-specific differences in the prevalence and presentation of insomnia as well as existing research regarding the relationship between insomnia and CVD outcomes as it pertains to sex. Research to date indicate that women are more likely to have insomnia than men, and there appear to be differential associations in the relation between insomnia and CVD by sex. We posit potential mechanisms of the relationship between sex, insomnia and CVD, discuss gaps in the existing literature, and provide commentary on future research needed in this area. Unraveling the complex relations between sex, insomnia, and CVD may help to explain sex-specific differences in CVD, and identify sex-specific strategies for promotion of cardiovascular health. Throughout this review, terms “men” and “women” are used as they are in the source literature, which does not differentiate between sex and gender. The implications of this are also discussed.
Giant thoracic ganglioneuroma with lymph node infiltration of a child: a case report
Authors: Hettiarachchi Mathula , Dharmadasa Chanuka , Wijeyananda Ashoka , Hettiarachchi Kapila , Samarasinghe Bandula
Published: December 2020

Background

Ganglioneuroma is a rare neurogenic tumor which could grow into massive size in the thorax with minimal or no symptoms. Resection of these tumors will be challenging in view of large size and vascular encasement. Here, we report resection of a thoracic ganglioneuroma in a child with infiltration of spinal canal and lymph node metastasis, which is a very rare occurrence.

Case presentation

A 3-year and 10-month-old girl presented with a left side thoracic mass with minimal symptoms and signs. After the initial imaging with ultrasound scan and cross-sectional imaging, she had a true cut biopsy of the lesion confirming the diagnosis of ganglioneuroma. On exploration, she had a paraspinal thoracic mass extending from level of arch of aorta down to diaphragm with evidence of tumor infiltration of the intercostal spaces and spinal canal in multiple vertebral levels. Pathologically, she had infiltrated lymph nodes which were encircling the lower thoracic aorta. The tumor was resected successfully, and she recovered with a good functional status.

Conclusion

Thoracic ganglioneuroma has a good prognosis after complete resection even with spinal canal and lymph node infiltration. The resection could be arduous in case of massive size and vascular encasement; hence, benefit versus risk of complete resection should be carefully weighed.
Dosimetric effect of the intestinal gas of online adaptive stereotactic body radiotherapy on target and critical organs without online electron density correction for pancreatic cancer
Authors: Su Chen , Okamoto Hiroyuki , Nishioka Shie , Sakasai Tatsuya , Fujiyama Daisuke , Miura Yuki , Tsunoda Yuki , Kuwahara Junichi , Nakamura Satoshi , Iijima Kotaro , Chiba Takahito , Kaga Keita , Takemori Mihiro , Nakayama Hiroki , Katsuta Shouichi , Inaba Koji , Igaki Hiroshi , Nakayama Yuko , Itami Jun
Published: December 2020

Objective:

This study aimed to assess the dosimetric effect of intestinal gas of stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) on target and critical organs for pancreatic cancer without online electron density correction (EDC).

Methods:

Thirty pancreatic cancer patients who underwent online SMART were selected for this study. The treatment time of each stage and the total treatment time were recorded and analyzed. The concerned dose-volume parameters of target and organs-at-risk (OAR) were compared with and without an intestinal gas EDC using the Wilcoxon-signed rank test. Analysis items with p value < 0.05 were considered statistically significant. The relationships between dosimetric differences and intestinal gas volume variations were investigated using the Spearman test.

Results:

The average treatment time was 82 min, and the average EDC time was 8 min, which accounted for 10% of the overall treatment time. There were no significant differences in CTV (GTV), PTV, bowel, stomach, duodenum, and skin (p > 0.05) with respect to dose volume parameters. For the D  max of gastrointestinal organs (p = 0.03), the mean dose of the liver (p = 0.002) and kidneys (p = 0.03 and p = 0.04 for the left and right kidneys, respectively), there may be a risk of slight overestimation compared with EDC, and for the D  max of the spinal cord (p = 0.02), there may be a risk of slight underestimation compared with EDC. A weak correlation for D  95 in the PTV and D  0.5 cc in the duodenum was observed.

Conclusion:

For patients with similar inter-fractional intestinal gas distribution, EDC had little dosimetric effects on the D  0.5 cc of all GI organs and dose volume parameters of target in most plans.

Advances in knowledge:

By omitting the EDC of intestinal gas, the online SMART treatment time can be shortened.
Διαφοροποιημένη παιδαγωγική & ενταξιακή εκπαίδευση: θεωρητικές επισημάνσεις, προβληματισμοί και προοπτικές
Authors: Ζώνιου-Σιδέρη Αθηνά , Λαμπροπούλου Κωνσταντίνα , Παπασταυρινίδου Γεωργία , Τσερμίδου Λία , Χριστοπούλου Αθηνά
Published: December 2020

Στο πλαίσιο των ταχύτατα μεταβαλλόμενων κοινωνικοπολιτικών συνθηκών και της απόπειρας εναρμόνισης των εκπαιδευτικών πολιτικών, τόσο σε εθνικό όσο και σε διεθνές επίπεδο, αφενός, με τα κυρίαρχα κοινωνικά και οικονομικά δεδομένα και, αφετέρου, με τις διεθνείς διακηρύξεις και συμβάσεις για τα ανθρώπινα δικαιώματα στην εκπαίδευση, η διαφοροποιημένη παιδαγωγική υποδεικνύεται σταθερά ως μια διδακτική πρακτική εν δυνάμει ικανή να ανταποκριθεί στην ετερογένεια του μαθητικού πληθυσμού. Η υπόδειξη αυτή συνοδεύεται από την υπόσχεση της συμβολής της διαφοροποίησης στην πρόληψη της σχολικής αποτυχίας και, ειδικότερα, την ένταξη στη γενική τάξη μαθητών που κατατάσσονται σε ειδικές κατηγορίες του μαθητικού πληθυσμού. Σε αυτό το πλαίσιο, το παρόν άρθρο θα επιχειρήσει να παρουσιάσει το θεωρητικό πλαίσιο βάσει του οποίου η διαφοροποιημένη παιδαγωγική συναρθρώνεται με το πεδίο των ενταξιακών παιδαγωγικών προσεγγίσεων καθώς και τη σύνδεση μεταξύ θεωρητικού λόγου και παιδαγωγικής πράξης στο πεδίο της διαφοροποίησης. Θα καταλήξει θέτοντας μία σειρά ευρύτερων προβληματισμών και αντιφάσεων που σχετίζονται: α) με το κατά πόσο η ανταπόκριση στη μαθητική ετερογένεια μέσα από την υιοθέτηση των αρχών της διαφοροποιημένης παιδαγωγικής, αντανακλάται σε αντίστοιχες αλλαγές στα δομικά χαρακτηριστικά του εκπαιδευτικού συστήματος και β) με το αν η διαφοροποιημένη παιδαγωγική στο υπάρχον πλαίσιο της εκπαιδευτικής πολιτικής εντέλει νοηματοδοτείται ως μια τεχνική διαχείρισης των μαθητών που κατατάσσονται σε «ειδικές» ομάδες του μαθητικού πληθυσμού με απώτερο στόχο την «κανονικοποίησή» τους και τη συνακόλουθη νομιμοποίηση υφιστάμενων πρακτικών διάκρισης και διαχωρισμού.
Polynomial expansions via embedded Pascal’s triangles
Authors: Provost Serge B. , Ratemi Wajdi M.
Published: December 2020

An expansion is given for polynomials of the form (ω + λ1) · · ·(ω +λn). The coefficients of the resulting polynomials are related to their roots, and a system of equations that enables one to numericallydetermine the roots in terms of the coefficients is specified. The case where all the roots λi are equal is considered as well. A multinomial extension to polynomials of the form (x1+ · · · + xI )n is then provided. As it turns out, the coefficients of the monomials contained in the resulting polynomial expansion can be determined in terms of the coefficients of the monomials included in the expansion of (x1+ · · · + xI-1 )n  and the rows of embedded Pascal’s triangles of successive orders. An algorithm is provided for generating and concatenating these rows, with the particulars of its implementation by means of the symbolic computation software Mathematica being discussed as well. Potential applications of such expansions to combinatorics and genomics are also suggested.
On characterization of horizontal biharmonic curves in H^2 × R
Authors: Körpinar Talat , Turhan Essin
Published: December 2020

In this paper, we study biharmonic curves in H2 × R. We show that all of them are helices. By using the curvature and torsion of the curves, we give some characterizations of horizontal biharmonic curves in H2 × R.
Internet game "Sign me up as an astronaut" for the formation of the social and psychological experience of younger adolescents with disabilities by means of game psychocorrection
Authors:   http://virtualklass24.ru/enrol/index.php?id=104, Styugina Anastasia
Published: December 2020

In the practice of a teacher-psychologist at the School of Distance Education, the game “Sign me up as an astronaut”, developed by the author, was tested, aimed at developing the skills of social and psychological interaction in younger adolescents with disabilities through the awareness and strengthening of personal resources by means of game psychocorrection. The specifics of the work of a psychologist at the School of Distance Education are determined by the following circumstances: - students have a severe disability and the corresponding psychophysical characteristics: instability of the emotional-volitional sphere, lack of motivation, severe physical and mental fatigue, low level of social skills, etc. - the use of distance educational technologies in psychocorrectional work; - lack of methodological recommendations for psychocorrectional work in conditions of distance technologies with school-age children. Such recommendations are available mainly for adults, they relate to the educational process, but they do not cover the correctional process. There is enough scientific and methodological literature on psychological and pedagogical correction, which is the basis for ensuring the work of a practicing psychologist, but there are difficulties in transferring these techniques, games, etc. - to the remote mode of correctional and developmental work, especially in the form of group work. During the game, various social and psychological situations are solved, which are selected strictly according to the characteristics of the social experience of the participants.
INCREASES IN SCR ENERGETIC PROTON FLUXES ON EARTH AND THEIR RELATION TO SOLAR SOURCES
Authors: Lazutin Leonid
Published: December 2020

Logachev catalog data for solar cycle 23 has been used to study the dependence of measured increases in solar cosmic rays (SCRs) on solar perturbations. The efficiency of recording the SCR increases, driven by proton acceleration in the corona, on Earth and in its vicinity is shown to depend on power of a solar flare that created a shock wave and on position of the flare on the solar disk. As the particle flux moves along the heliolongitude away from the parent flare, the acceleration efficiency decreases, i.e. the maximum energy of the accelerated particles and their intensity at equal energy decrease. As a result, at a certain distance along a heliolongitude from the parent solar flare, the solar proton flux intensity decreases to the galactic background, and there is no SCR increase detected.
GEOMETRIC FACTOR IN SEASONAL VARIATIONS OF DAILY AVERAGE VALUES OF THE GEOMAGNETIC INDEX Dst
Authors: Makarov Georgy
Published: December 2020

The work uses data on the geomagnetic index Dst for the period 1966–2015. Under quiet conditions, the occurrence of seasonal variations of the daily average Dst index depends on geometric factors of the interaction between the solar wind and the magnetosphere; and under disturbed conditions, on the development of a partial ring current in the magnetosphere. At large negative values of the Dst index, there is no seasonal variation in it. The imperfection of the network of Dst stations is assumed to lead to the formation of annual variation in Dst. The formation of a semiannual variation is associated with the movement of the plasma sheet relative to the plane of the geomagnetic equator during the annual rotation of Earth around the Sun. Based on the data on semiannual variations in the number of days n(Dst), the critical daily average value of the geomagnetic index Dst is determined, starting from which we can speak of disturbed days: Dst≤–24 nT.
Classification of magnetospheric responses to interaction with diamagnetic structures of slow solar wind
Authors: Parhomov Vladimir , Eselevich Viktor , Eselevich Maxim , Dmitriev Alexei , Suvorova Alla , Vedernikova Tatyana
Published: December 2020

We propose a possible classification of the responses of the magnetosphere to the interaction with diamagnetic structures (DS), which form the basis of the slow solar wind. The main determinants of the classification are the value and orientation of the vertical component Bz of the interplanetary magnetic field (IMF) and the solar wind density N. We have identified three types of magnetospheric responses. Type 1 has two subtypes whose main difference is the presence or absence of auroras on the day side of the magnetosphere. Within an hour before DS arrival, Bz has a positive value (up to 12 nT) or fluctuates about 0 in the range from –1 to +1 nT. For both subtypes, the duration of substorm disturbances approximately coincides with the duration of DS, and their intensity does not exceed AE~500 nT. Type 2 is characterized by the fact that before the contact with DS positive IMF Bz (0–10 nT) is recorded for an hour, and at the interface of DS a rapid (≤2 min) change in the orientation of the IMF vertical component from north to south occurs. For type 3, Bz within an hour before the contact with DS is negative (from –10 to 0 nT).

We address the problem of DS energy transfer to the magnetosphere.
IDENTITÉS AFROPÉENNES DANS BLUES POUR ELISE DE LÉONORA MIANO
Authors: Coste Marion
Published: December 2020

Blues pour Elise met en scène des personnages de jeunes femmes afropéennes (c’est-à-dire d’origine africaine ou antillaise mais qui se reconnaissent principalement dans la culture de l’hexagone) de la classe moyenne. La question de la race est présente, mais sans insistance: ce sont les histoires d’amour des personnages qui occupent le récit. Nous verrons que cette manière de mettre la question de la race en arrière-plan permet à Léonora Miano d’éviter les stéréotypes misérabilistes auxquels les personnages noirs des romans français sont trop souvent réduits. Au contraire, dans ce roman, elle construit une grande diversité de modèles identitaires afropéens à travers ses personnages. Le roman offre également un « territoire mental » afropéen grâce aux références musicales présentes à la fin de chaque chapitre.
Cross-cultural adaptation and psychometric evaluation of the French version of the Gilles de la Tourette Syndrome Quality of Life Scale (GTS-QOL)
Authors: Jalenques Isabelle , Cyrille Diane , Derost Philippe , Hartmann Andreas , Lauron Sophie , Jameux Clara , Tauveron-Jalenques Urbain , Guiguet-Auclair Candy , Rondepierre Fabien ,   for The Syndrome de Gilles de La Tourette Study Group
Published: December 2020

Introduction

The Gilles de la Tourette Syndrome–Quality of Life Scale (GTS-QOL) is a self-rated disease-specific questionnaire to assess health-related quality of life of subjects with GTS.

Our aim was to perform the cross-cultural adaptation of the GTS-QOL into French and to assess its psychometric properties.

Methods

The GTS-QOL was cross-culturally adapted by conducting forward and backward translations, following international guidelines. The psychometric properties of the GTS-QOL-French were assessed in 109 participants aged 16 years and above with regard to factor structure, internal consistency, reliability and convergent validity with the MOVES (Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey) and the WHOQOL-BREF (World Health Organization Quality of Life Brief).

Results

Exploratory factor analysis of the GTS-QOL-French resulted in a 6-factor solution and did not replicate the original structure in four subscales. The results showed good acceptability (missing values per subscale ranging from 0% to 0.9%), good internal consistency (Cronbach’s alpha ranging from 0.68 to 0.94) and good test–retest reliability (intraclass correlation coefficients ranging from 0.70 to 0.81). Convergent validity with the MOVES and WHOQOL-BREF scales showed high correlations.

Discussion

Our study provides evidence of the good psychometric properties of the GTS-QOL-French. The cross-cultural adaptation and validation of this specific instrument will make it possible to assess health-related quality of life in French-speaking subjects with GTS. The GTS-QOL-French could be recommended for use in future research.
Regionalization for health improvement: A systematic review
Authors: Ramos Maíra Catharina , Barreto Jorge Otávio Maia , Shimizu Helena Eri , Moraes Amanda Pereira Gomes de , Silva Everton Nunes da
Published: December 2020

Regionalization is the integrated organization of a healthcare system, wherein regional structures are responsible for providing and administrating health services in a specific region. This method was adopted by several countries to improve the quality of provided care and to properly utilize available resources. Thus, a systematic review was conducted to verify effective interventions to improve health and management indicators within the health services regionalization. The protocol was registered in PROSPERO (CRD42016042314). We performed a systematic search in databases during February and March 2017 which was updated in October 2020. There was no language or date restriction. We included experimental and observational studies with interventions focused on regionalization-related actions, measures or policies aimed at decentralizing and organizing health offerings, rationalizing scarce capital and human resources, coordinating health services. A methodological assessment of the studies was performed using instruments from the Joanna Briggs Institute and GRADE was also used to assess outcomes. Thirty-nine articles fulfilled the eligibility criteria and sixteen interventions were identified that indicated different degrees of recommendations for improving the management of health system regionalization. The results showed that regionalization was effective under administrative decentralization and for rationalization of resources. The most investigated intervention was the strategy of concentrating procedures in high-volume hospitals, which showed positive outcomes, especially with the reduction of hospitalization days and in-hospital mortality rates. When implementing regionalization, it must be noted that it involves changes in current standards of health practice and in the distribution of health resources, especially for specialized services.
Evaluation of oral pathologic lesions in elderly patients in Isfahan, Iran, 1989-2018 years
Authors: Maleki Laleh , Kargahi Neda , Hatefi Seyed Ehsan
Published: December 2020

Objective: One of the most important alterations in elderly is the destruction and loss of teeth and oral mucosal lesions. The aim of this study was to determine the frequency of biopsed pathologic lesions in elderly registered in the pathology department of Isfahan University of Medical Sciences during 1989 to 2018 years. Material and Methods: This crosssectional descriptive-analytic study was performed on pathologic lesions in elderly archived in Faculty of Dentistry, Isfahan University of Medical Sciences. In this study, all archived information of elderly over 65 years including gender, age, location of lesion, clinical diagnosis, pathology diagnosis, and diagnosis year were evaluated in last three decades, and were analyzed statistically. Results: The age range of elderly patients was 65 to 90 years with a mean of 72.8 ± 4.9. The highest frequency for location of lesions was related to mandibular vestibule (21.1%). The most clinical diagnosed lesions were squamous cell carcinoma (24.5%) and Epulis Fissuratum (13.4%). The highest pathologic diagnosed lesions were related to reactive lesions group (35.6%). The squamous cell carcinoma malignancies and other malignancies were increased significantly in elderly patients with high age. Conclusion: According to the considerable frequency of oral lesions in elderly and increased frequency of squamous cell carcinoma and other malignancies, attention to oral lesions in elderly and periodic examinations are important to early diagnosis and treatment.
KEYWORDS
Pathology; Biopsy; Elderly; Oral lesions; Isfahan.
Sex determination by osteometric assessment of the mastoid process using Cone Beam Computed Tomography
Authors: Salemi Fatemeh , Farhadian Maryam , Shokri Abbas , Safi Yaser , Rahimpanah Shahin
Published: December 2020

Objective: Sex determination is one of the most important parameters to identify in forensic science. Because the mastoid process is the most resistant to damage due to its position in the skull base, it can be used for sex determination. The purpose of this study was to measure the dimensions and convexity and internal angles of the mastoid process to present a model of sex determination in Iranian population. Material and methods: This study was performed on three-dimensional images of 190 Cone Beam Computed Tomography (CBCT) of 105 women and 85 men. On each CBCT the distance between the porion and the mastoid (PM), mastoid length (ML), the distance between the mastoidale and the mastoid incision (M-I), the mastoid height (MH), the mastoid width (MW), intermastoidale distance (IMD) the lateral surfaces of the left and right mastoids (IMLSD) and the Mastoid medial convergence angle (MMCA) was measured on both the right and the left. The data were analyzed by descriptive statistics, t-test, and discriminant function analysis. Results: Significant differences were found for all variables except MMCA and MF in both sex. All measured variables except MW were greater for men than women. The discriminant model achieved a total accuracy of 93.7%. Among the measured factors IMD and IMSLD had the most influence on sex determination. Conclusion: Measuring the dimensions of the mastoid process is a very good method for sex determination with high accuracy of 90%.
KEYWORDS
Discriminant model; Cone beam computed tomography (CBCT); Sex determination; Mastoid process.
Comparative evaluation of antimicrobial potential of herbal extracts on Streptococcus mutans and Enterococcus faecalis: An in vitro study
Authors: Tatekalva Pranati , Subbaiyan Haripriya , Rajesh Kumar Shanmugam
Published: December 2020

Though aloe vera extract, green tea extract and coriander oil are proven antimicrobial agents, very little information is available regarding its effects on oral bacteria, Streptococcus mutans,which is responsible for initiating caries and Enterococcus faecalis, responsible for failure of root canal treatment. Objective: To find the antimicrobial activity of aloe vera extract, black tea extract and coriander oil against S. mutans and E. faecalis. Materials and Methods: The agar well diffusion method was used to determine the antibacterial activity of Aloe vera extract, black tea extract and coriander oil. Different concentration of prepared plant extracts and coriander seed oil (50 & 100 µl) was incorporated into the wells and the plates containing S. mutans and E. faecalis were incubated at 37 ºC for 24h. The antibiotic (amoxicillin 30 µl) was used as positive control. Zone Of Inhibition (ZOI) was recorded in each plate. Results: For S. mutans, the maximum ZOI was created by coriander oil with a diameter of 25.00±0.58 mm at 50 µl and for E. faecalis, maximum ZOI was created by aloe vera extract 16.00±0.58 mm at 100 µl concentration which were far better than the control: amoxicillin 30 µl concentration.
Conclusion: The extracts of Aloe vera, black tea and coriander oil, showed significant activity against the investigated microbial strains, Streptococcus mutans and Enterococcus faecalis which further helps in the development of new topical agents that help in reducing the numbers of these organisms present in the oral cavity.
 
Keywords
Oral microbiota; Aloe vera; black tea; coriander oil; E. faecalis; S.mutans.
A CBCT aided assessment for the location of mental foramen and the emergence pattern of mental nerve in different dentition status of the Saudi Arabian population
Authors: Srivastava Kumar Chandan
Published: December 2020

Objective: The anatomy of mental foramen (MF) is a noteworthy landmark during any surgical procedures in the inter-foraminal region. Thus, the study aims at evaluating the location of MF and the emergence pattern of MN in three status of dentition in Saudi Arabian population. Material and Methods: In a prospective study, we have analyzed 240 cone beam computed tomography (CBCT) for the location of MF and the emergence pattern of MN. The study comprising three groups, namely dentulous, partially edentulous and edentulous, each having eighty CBCT scans. We presented the data in percentages. The chisquare and McNemar’s test were used for testing association and pair-wise analysis, respectively. Results: The most common location of MF was below the apex of the second premolar irrespective of dentition status, with 54.2% in right and 60% in the left side of the jaw. Among the dentition status, left side of the mandible has shown significant variation for the location of MF, whereas gender and age showed variation in the right side. Anterior loop (AL) (Type-III) the emergence pattern of MN was the highest in all dentition status, with 51.7% in right and 53.8% on the left side. The variation in the emergence pattern of MN in terms of gender and side of the jaw was statistically significant. Conclusion: In the Saudi Arabian population, the apex of second premolar and type III/AL was the most prevalent location of MF and the emergence pattern of MN, respectively.
KEYWORDS
Anterior loop; Cone beam CT; Mandible; Mental foramen; Mental nerve.
Educação Ambiental em contextos de Educação Não Formal: uma análise de práticas educativas desenvolvidas no Zoológico de Pomerode
Authors: Rodrigues Fernanda , Schulz Luciane , Tomio Daniela
Published: December 2020

Dentre os papeis atribuídos aos zoológicos modernos, enquanto espaços de educação não formal, está a promoção da Educação Ambiental de seus visitantes. Com base nisso, objetivamos analisar as práticas educativas em Educação Ambiental desenvolvidas no Zoológico de Pomerode e identificar sob quais tendências são materializadas. Para isso, realizamos uma pesquisa de campo, com a geração de dados a partir de observação participante, questionários aplicados aos educadores ambientais e leitura de relatórios do Zoo. Interpretamos que as práticas desenvolvidas, evidenciam concepções conservacionistas e pragmáticas em sua maioria, em consonância com a função do zoológico de conservação da biodiversidade. Sugerimos que se exerça uma reflexão da prática na direção de uma educação ambiental crítica.
Olho por olho
Authors: Seves Deister de Sousa Vanessa
Published: December 2020

O que aconteceria se Tunga e Marcel Duchamp jogassem xadrez? Ambos em suas fases maduras, cada qual com seu respectivo tabuleiro? A impossibilidade de respostas para essas perguntas enfrenta o diálogo mudo estabelecido por dois registros fotográficos que conversam através do tempo e do espaço. Um dos registros encontra-se no livro “Olho por Olho”, publicado pelo artista brasileiro juntamente com outros seis volumes na “Caixa Tunga” (2007). A fonte do outro registro se perdeu, mas poderia fazer parte de alguma série ready-made de Duchamp ou de sua “Caixa Valise” criada em 1941. A partir desse jogo de xadrez imaginário é possível refletir tanto sobre a poética, quanto sobre a cuidadosa forma como ambos os artistas construíram suas publicações. Este é o propósito do presente artigo: pensar na complexidade do pensamento de Tunga sob o fio condutor da obra “Olho por Olho”, que assume uma configuração completamente nova a partir de sua publicação no livro homônimo, tendo como interlocutora parte da poética de Marcel Duchamp.
A participação de mulheres artistas na revista Ephemera
Authors: Costa Andréia Paulina
Published: December 2020

Esse artigo têm como intuito analisar a revista Ephemera produzida por Ulises Carión entre os anos de 1977 e 1978, sob uma perspectiva de gênero. Dentre os doze números editados pela revista, como se deu a participação das artistas e em que medida seus trabalhos contribuíram de forma exemplar para a proposta crítica e experimental do escopo editorial e quais as problematizações por elas levantadas.
The Effect of Pyramid Method Digital Processing to Enhance the Ground Goals Images for Masscrafts
Authors: Salim Rana Ali
Published: December 2020

While Mechanism of Objective Marking of Automated Marking is approaching the latest technique mainly; the approach has an important aspect; where assansoyn fellow complete the mechanical teaching curriculum by filling up the niche in the near term. While inexplicable isn't fully understood, validates discrimination decisions in mechanical teaching, thus instilling confide in ML goal calls. Alternatively, the approach via can act as a standalone element, especially in scenarios where a little amount of benefit, for example, "Today's the interactions of curricula via don't require train data, and thus prove different mechanical teaching curricula for accurate train data. So that an example-via approach, which screen shoot prominent goal shape data to identifying in a large-scale satellite imagery. The right mix of coarse three dimensions aims finds the abstract form and realism of the goals to provide strength against objective differences discrimination at the same time. The curriculum uses powerful new forms of image correlation to match the shape of expected objectives with the image. Look for shape projections about setting, and use engineering property objectives and shadow projections. Binding factors provide tolerance to lighting differences, temperate covers; where many true subjects. To provide distinguishing digital objective on realistic satellite imagery that illustrates performance.