bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishing a cellular model for drug screening targeting TRPV4
Authors: Zheng Kai , Hu Jiang , Liu Xueying , Xing Wenzhu , Hong Qiyuan , Hu Cheng , Hao Feng
Published: July 2023

Transient receptor potential cation channel subfamily V (TRPV4) is a widely expressed multimodal gated ion channel that transports Ca2+ intracellularly upon opening and plays an important role in many physiological and pathological processes. However, existing TRPV4 channel regulators lack specificity and are ineffective, and available screening methods are not suitable for high-throughput screening of regulators. Therefore, in this study, we developed a cellular model and method for high-throughput drug screening targeting TRPV4 channels based on a double mutant(YFP-H148Q/I152L) of the yellow fluorescent protein (YFP) and the calcium-activated chloride channel protein 1, Anoctamin 1 (ANO1). The endogenous expression of TRPV4 in Fischer Rat Thyroid (FRT) cells was determined, TRPV4 ion channel function in FRT cells was verified by electrophysiological techniques, and a TRPV4 cell model co-expressing ANO1 and YFP-H148Q/I152L was constructed. The model was verified to sensitively detect changes in intracellular Ca2+ concentration using membrane clamp experiments and fluorescence quenching kinetics, and the function of the TRPV4 cell model was examined under different temperatures and concentrations of TRPV4 regulators. The model was evaluated to perform well in high-throughput screening.
Mannan and anti-CD40 antibody decorated and tumor antigen, CpG and Poly I:C encapsulated poly lactic-co- glycolic acid (PLGA) nanoparticles loaded dendritic cells induced type I immune responses against prostate cancer ex vivo
Authors: Ziamiavaghi Negin , Delirezh Nowruz , Sheikhzadeh Sanaz
Published: July 2023

Purpose
Cancer vaccines that stimulate the immune system to detect tumor-related antigens and trigger a T cell response have shown remarkable success in prostate cancer immunotherapy. In this study, we used PLGA nanoparticles and a carrier to deliver TCL, CPG-ODN, and Poly I:C to dendritic cells. We engineered the surface of the nanoparticles with mannan and anti-CD40 antibodies to specialize TCL delivery to dendric cells. We estimated different molecules and adjuvants' effects on DCs and T cell activation.
Method
In this study, Poly lactic-co-glycolic acid (PLGA) nanoparticles encapsulated with LNCaP cell line tumor antigens as well as Polyinosinic: polycytidylic acid (Poly: IC) and CpG-ODN as adjuvants. Mannan (MN) and Anti-CD40 antibody were then attached to the surface of PLGA nanoparticles. Monocyte-derived dendritic cells were generated, and on day 4, tumor cell lysate (TCL) and 8 different groups of nanoparticles were added to DCs to stimulate T lymphocytes and measure T cell response in vitro.
Result
Our results showed that using TCL, CpG-ODN, and Poly I:C encapsulated in nanoparticles and decorating the surface of nanoparticles with Mannan and anti-CD40 can induce maturation of dendritic cells and stimulate strong antitumor immune responses as well.
Conclusion
Therefore, combining TCL and adjuvants within nanoparticles and decorating them with Mannan and anti-CD40 enhances antitumor immune responses and can be considered an effective treatment strategy in prostate cancer.
A case report about polycythemia vera and a pregnant woman
Authors: Ma Shuxin , Luo Xia
Published: July 2023

Background: Polycythemia vera (PV), belonging to the myeloproliferative disorder, refers to the apparent overproduction of red blood cells. This pathological change culminates in blood hyperviscosity, which causing pregnant women with high risk of thrombosis. In this study, we introduced a rare case about a pregnant woman with PV in China.
Case summary: In this case report, we summarized the process of diagnosis and treatment about the pregnant woman with previously diagnosed PV during her gestation time. The first onset of this disease was in her twenty-second. She was supplied with hydroxyurea and interferon and got symptoms relieve. But she didn’t undergo regular treatment after that. She was hospitalized during gestation in her thirty-first, treated with regular administration of phlebotomy, aspirin (100mg), and low molecular weight heparin (LMWH). Finally, the patient delivered a healthy newborn after the cesarean.
Conclusion: Early diagnosis and intervention can effectively prevent pregnancy complications. Flexible control of hematocrit levels combined with anticoagulation contributes to improving pregnancy outcomes.
Benefícios da Ozonioterapia nas Patologias Bucomaxilofaciais
Authors: Rosa Lívia Raquel de Oliveira , Araújo Juliana Batista , Aguiar Kananda Loiola Fernandes de , Costa Matheus Moreira Lima , Ferreira Vanessa Assunção , Marques Daniele Meira Conde , Casanovas Rosana Costa
Published: July 2023

Introdução: O Ozônio é um gás presente abundantemente na natureza que possui propriedades antimicrobianas e anti-inflamatórias. Os benefícios da ozonioterapia nas patologias bucomaxilofaciais vêm sendo amplamente estudados nas últimas décadas. Objetivo: O objetivo deste estudo foi analisar a contribuição da ozonioterapia na associação entre duas áreas correlatas: a Patologia Oral e a Cirurgia Bucomaxilofacial. Material e método: Trata-se de um estudo descritivo, exploratório, desenvolvido por meio de revisão sistemática da literatura. Foi realizada uma busca em diversas bases de dados. Foram encontrados 331 estudos nas línguas portuguesa e inglesa, não houve restrição de data de publicação. Vinte e nove trabalhos que contemplaram os critérios de inclusão foram selecionados. Resultados: Os achados sugerem que a ozonioterapia promove hemostasia, tem efeito imunomodulador, aumenta o suprimento local de oxigênio e a microcirculação dos tecidos, diminui a produção de mediadores pró-inflamatórios, inibe o crescimento bacteriano, entre outros benefícios. Conclusão: As evidências mostram que a ozonioterapia traz benefícios para o tratamento de patologias bucais e maxilofaciais, apresenta raras complicações e tem uma aplicabilidade segura e minimamente invasiva.
Comparación del protocolo CoSynch con y sin adición de progesterona y eCG sobre la tasa de preñez y el diámetro folicular en novillas Bos indicus
Authors: Salgado Otero Roger Daniel , Vergara Garay Oscar David , Sehuanes Hoyos Julia Edith , Vergara Avilez María Angélica
Published: July 2023

La iatf es una herramienta biotecnológica que permite el control del ciclo estral de la hembra a través de la incorporación de compuestos hormonales que precisan el momento exacto del celo y la ovulación. La combinación de estos compuestos ha permitido el surgimiento de innumerables protocolos hormonales que buscan mejorar la sincronización. El objetivo de este estudio fue evaluar el uso de protocolos hormonales a base de la hormona liberadora de gonadotropina (GnRH) sobre la fertilidad de novillas Bos indicus. Se sincronizaron 180 novillas (cíclicas y acíclicas) de la raza Brahman. Los tratamientos experimentales correspondieron a tres protocolos que incluyeron las siguientes hormonas: GNRH-PGF2-GNRH (T1 y T2), DIB-GNRH-PGF2-GNRH (T3 y T4) y DIB-GNRH-PGF2-eCG-GNRH (T5 y T6). A los animales se les evaluó el tamaño del folículo preovulatorio y el diagnóstico de preñez por medio de ultrasonografía, con los protocolos de sincronización se obtuvo una tasa de preñez total de: 10,7 % (T1), 16,6 % (T2), 36,8 % (T3), 41,9 %(T4), 38,7 % (T5) y 27,68 % (T6). Se encontró un efecto (p = 0,0803) entre los tratamientos al realizar la comparación de proporciones de preñez y se encontró que el T1 y el T2 fueron estadísticamente iguales (p > 0,05) y lo mismo sucedió con los tratamientos T3, T4, T5 y T6, pero se encontraron diferencias (p ≤ 0,05) entre los tratamientos T1 y T2 al compararlos con los tratamientos T3, T4, T5 y T6; por otro lado, no hubo diferencias (p ≥ 0,05) en el promedio del tamaño de folículo preovulatorio, siendo estos de 10,28 mm, 11,21 mm y 11,77 mm para las novillas sincronizadas con los tratamientos 1, 2 y 3, respectivamente. El uso de la hormona GnRH en combinación con la progesterona en protocolo Cosynch mejora significativamente las tasas de preñez en novillas Bos indicus, en comparación al protocolo Cosynch tradicional.
Problem of Tribal Education: Issues & Challenges
Authors: Chaudhari Dr. Ashish Kant
Published: July 2023

Abstract: Tribes have a diverse way of living with a distinct traditional pattern. Maximum numbers of tribal communities lived in Madhya Pradesh, Uttar Pradesh Bihar Orissa (Gonds, Dhuriya, Nayak, Tharu, Shariya, Baiga, Panika, Agaria, Bhotia etc) They live a despondent life without enough possessions and have a lot of issues and problem such as economic problem, literacy, unemployment, housing problem etc., a lot of informative problem are faced by tribal communities. Hence government is trying his best to resolve all these problems with the implementation of new schemes & Problems. This study concentrations on the made by government schemes for upliftment of the tribes and deliberates the major challenges to solve the educational problem.
The technique of UAV-based airborne laser scanning data preliminary processing
Authors: Altyntsev M.A.
Published: July 2023

The technique of UAV-based airborne laser scanning data preliminary processing is proposed. Its main steps, such as filtering the data, determining the calibration parameters of the survey system, strip adjustment of trajectories and point clouds are described and analyzed. The high density of a point cloud, which is the basic feature of the measurements made at low altitude, is taken into account. The study of the technique was carried out on the example of urban area data obtained with the laser scanner AGM-MS3. This information served to develop filtering and relative orientation algorithms. The initial data AGM-MS3 were also analyzed for the need to adjust them when the distance between adjacent strips is short. It is concluded that the technique can be used to process data on any territory.
Principles of urbanized territories identification and indicators of their sustainable development
Authors: Chernykh E.G. , Ainullina K.N.
Published: July 2023

The term "urbanized territories" is relatively new in the domestic literature, so there is no certainty in their identification. The purpose of this study is to determine the principles for identifying them, establishing indicators of sustainable development. When writing the article, methods of analysis and synthesis as well as statistical ones were used. At studying, it was proved that all categories of land can be attributed to urbanized territories. The main results were the establishment of the basic principles for identifying urban areas, calculation of the Tyumen region territory spatial development indicators, and those of sustainable development. The authors propose a qualitatively new approach to determining the essence of urbanized areas, which will help scientific communities in carrying out further research in this locality.
Diversity and Equity in Accounting Education during COVID-19: Insights from Colombia
Authors: Casa Nova Silvia Pereira de Castro , Patiño-Jacinto Ruth Alejandra , Macias Hugo A.
Published: July 2023

This paper aims to open a window into diversity and inequity issues unveiled by COVID-19 in accounting education in a context of social and political unrest. Following interviews and autoethnographic written reports, a survey of Colombian accounting professors was examined and complemented by a student survey. The study drew on the concepts of conscientização and dialogic pedagogy, proposed by Brazilian social scientist Paulo Freire. The findings showed that the pandemic enabled students and faculty to move from a magical to a critical stage of conscientização (critical consciousness). The pandemic led them to reflect on their context, question the role of accounting, and advance their liberation from oppressive positions. We ended our research with the claim a student posted on their profile: “How hard it is to study while they are killing my people!” Future studies may extend the scope of research to other periods and geographic contexts.
Disclosure and Investor Inattention: Theory and Evidence
Authors: Bertomeu Jeremy , Hu Peicong , Liu Yibin
Published: July 2023

Investors have a finite capacity to organize all information they receive from financial disclosures. Under rational inattention, we show that investor processing capacity affects the probability of disclosure. Our main result is that the likelihood of disclosure is inverse-U shaped in investor attention. For low levels of attention, more attention facilitates communication and increases disclosure; for high levels of attention, more attention better identifies, and therefore deters, unfavorable voluntary disclosures. We provide empirical evidence that the relationship between investor attention and management forecast follows the predictions of the theory, using institutional ownership as a proxy for investor attention as well as exogenous shocks to fund manager distraction.

JEL Classifications: D83; G14; M4.
Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling
Authors: Sohn Paul , McLaughlin Madeline R. , Krishnan Preethi , Wu Wenting , Slak Rupnik Marjan , Takasu Akira , Senda Toshiya , Lee Chih-Chun , Kono Tatsuyoshi , Evans-Molina Carmella
Published: July 2023

Altered endoplasmic reticulum (ER) Ca2+ signaling has been linked with β-cell dysfunction and diabetes development. Store-operated Ca2+ entry replenishes ER Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). For characterization of the in vivo impact of STIM1 loss, mice with β-cell–specific STIM1 deletion (STIM1Δβ mice) were generated and challenged with high-fat diet. Interestingly, β-cell dysfunction was observed in female, but not male, mice. Female STIM1Δβ mice displayed reductions in β-cell mass, a concomitant increase in α-cell mass, and reduced expression of markers of β-cell maturity, including MafA and UCN3. Consistent with these findings, STIM1 expression was inversely correlated with HbA1c levels in islets from female, but not male, human organ donors. Mechanistic assays demonstrated that the sexually dimorphic phenotype observed in STIM1Δβ mice was due, in part, to loss of signaling through the noncanonical 17-β estradiol receptor (GPER1), as GPER1 knockdown and inhibition led to a similar loss of expression of β-cell maturity genes in INS-1 cells. Together, these data suggest that STIM1 orchestrates pancreatic β-cell function and identity through GPER1-mediated estradiol signaling.

Article Highlights

Store-operated Ca2+ entry replenishes endoplasmic reticulum (ER) Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). β-Cell–specific deletion of STIM1 results in a sexually dimorphic phenotype, with β-cell dysfunction and loss of identity in female but not male mice. Expression of the noncanonical 17-β estradiol receptor (GPER1) is decreased in islets of female STIM1Δβ mice, and modulation of GPER1 levels leads to alterations in expression of β-cell maturity genes in INS-1 cells.
Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes
Authors: Wretlind Asger , Curovic Viktor R. , Suvitaival Tommi , Theilade Simone , Tofte Nete , Winther Signe A. , Vilsbøll Tina , Vestergaard Henrik , Rossing Peter , Legido-Quigley Cristina
Published: July 2023

Ceramides are lipid molecules involved in inflammation-related signaling. Recent studies have shown that higher amounts of specific circulating ceramides and their ratios are associated with future development of cardiovascular (CV) disease (CVD). We examined the associations between serum ceramide levels with CVD, kidney failure, and all-cause mortality in individuals with long-standing type 1 diabetes (T1D). We included 662 participants with T1D and 6-year follow-up, with a mean age of 55 years and mean diabetes duration of 33 years. Baseline serum samples were analyzed using liquid chromatography–mass spectrometry. Six predefined ceramide levels were measured, and predefined ratios were calculated. Adjusted Cox regression analyses on ceramide levels in relation to future CV events (CVE), kidney failure, and all-cause mortality were performed, with and without adjustment for age, sex, BMI, LDL, triglycerides, systolic blood pressure, HbA1c, history of CVD, smoking status, statin use, estimated glomerular filtration rate (eGFR), and urinary albumin excretion rate (UAER). The ceramide ratio cer(d18:1/18:0)/cer(d18:1/24:0) was significantly associated with risk of CVE (hazard ratio [HR] = 1.33, P = 0.01) and all-cause mortality (HR = 1.48, P = 0.01) before and after adjustments. All five investigated ceramide ratios were associated with kidney failure, before adjusting for the kidney markers eGFR and UAER. In this study, we demonstrate specific ceramides and ratios associated with 6-year cardiovascular risk and all-cause mortality in a T1D cohort. This highlights the strength of ceramide association with vascular complications and presents a new potential tool for early risk assessment if validated in other cohorts.

Article Highlights

Improved tools for assessing risk for diabetes complication before onset will help in complication prevention. We investigated a set of six predefined ceramides and their ratios versus 6-year outcomes of cardiovascular events, kidney failure, and all-cause mortality in people with long-standing type 1 diabetes, using Cox regression with and without adjustment for potential confounders. We found that several ceramides and ceramide ratios associated with cardiovascular events and all-cause mortality. The ratio of cer(d18:1/18:0)/cer(d18:1/24:0) was an especially robust marker. These finding show that ceramides can be biomarkers of cardiovascular disease and all-cause mortality in individuals with long-standing type 1 diabetes.
Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes
Authors: Schön Martin , Zaharia Oana P. , Strassburger Klaus , Kupriyanova Yuliya , Bódis Kálmán , Heilmann Geronimo , Strom Alexander , Bönhof Gidon J. , Michelotti Filippo , Yurchenko Iryna , Möser Clara , Huttasch Maximilian , Bombrich Maria , Kelm Malte , Burkart Volker , Schrauwen-Hinderling Vera B. , Wagner Robert , Roden Michael ,   GDS Group, Roden M. , Al-Hasani H. , Belgardt B. , Bönhof G.J. , Burkart V. , Buyken A.E. , Geerling G. , Herder C. , Icks A. , Jandeleit-Dahm K. , Kotzka J. , Kuß O. , Lammert E. , Rathmann W. , Schrauwen-Hinderling V. , Szendroedi J. , Trenkamp S. , Wagner R.
Published: July 2023

Intramyocellular lipid content (IMCL) is elevated in insulin-resistant humans, but it changes over time, and relationships with comorbidities remain unclear. We examined IMCL during the initial course of diabetes and its associations with complications. Participants of the German Diabetes Study (GDS) with recent-onset type 1 (n = 132) or type 2 diabetes (n = 139) and glucose-tolerant control subjects (n = 128) underwent 1H-MRS to measure IMCL and muscle volume, whole-body insulin sensitivity (hyperinsulinemic-euglycemic clamps; M-value), and cycling spiroergometry (VO2max). Subgroups underwent the same measurements after 5 years. At baseline, IMCL was ∼30% higher in type 2 diabetes than in other groups independently of age, sex, BMI, and muscle volume. In type 2 diabetes, the M-value was ∼36% and ∼62% lower compared with type 1 diabetes and control subjects, respectively. After 5 years, the M-value decreased by ∼29% in type 1 and ∼13% in type 2 diabetes, whereas IMCL remained unchanged. The correlation between IMCL and M-value in type 2 diabetes at baseline was modulated by VO2max. IMCL also associated with microalbuminuria, the Framingham risk score for cardiovascular disease, and cardiac autonomic neuropathy. Changes in IMCL within 5 years after diagnosis do not mirror the progression of insulin resistance in type 2 diabetes but associate with early diabetes-related complications.

Article Highlights

Intramyocellular lipid content (IMCL) can be elevated in insulin-resistant humans, but its dynamics and association with comorbidities remain unclear. Independently of age, sex, body mass, and skeletal muscle volume, IMCL is higher in recent-onset type 2, but not type 1 diabetes, and remains unchanged within 5 years, despite worsening insulin resistance. A degree of physical fitness modulates the association between IMCL and insulin sensitivity in type 2 diabetes. Whereas higher IMCL associates with lower insulin sensitivity in people with lower physical fitness, there is no association between IMCL and insulin sensitivity in those with higher degree of physical fitness. IMCL associates with progression of microalbuminuria, cardiovascular disease risk, and cardiac autonomic neuropathy.
Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling
Authors: Sohn Paul , R. McLaughlin Madeline , Krishnan Preethi , Wu Wenting , Slak Rupnik Marjan , Takasu Akira , Senda Toshiya , Lee Chih-Chun , Kono Tatsuyoshi , Evans-Molina Carmella
Published: July 2023

Altered endoplasmic reticulum (ER) Ca2+ signaling has been linked with β cell dysfunction and diabetes development. Store-operated Ca2+ entry (SOCE) replenishes ER Ca2+ through reversible gating of plasma membrane Ca2+ channels by the ER Ca2+ sensor, stromal interaction molecule 1 (STIM1). To characterize the in vivo impact of STIM1 loss, mice with a β cell-specific STIM1 deletion (STIM1Δβ mice) were generated and challenged with high-fat diet. Interestingly, β cell dysfunction was observed in female, but not male, mice. Female STIM1Δβ mice displayed reductions in β cell mass, a concomitant increase in α cell mass, and reduced expression of markers of β cell maturity, including MafA and UCN3. Consistent with these findings, STIM1 expression was inversely correlated with HbA1c levels in islets from female, but not male, organ donors. Mechanistic assays demonstrated that the sexually dimorphic phenotype observed in STIM1Δβ mice was due, in part, to loss of signaling through the noncanonical 17-β estradiol receptor (GPER1), as GPER1 knockdown and inhibition led to a similar loss of expression of β cell maturity genes in INS-1 cells. Together, these data suggest that STIM1 orchestrates pancreatic β cell function and identity through GPER1-mediated estradiol signaling. 

  
IMPLEMENTASI GOOGLE FORM SEBAGAI MEDIA EVALUASI PEMBELAJARAN BAHASA INGGRIS DI SMP NEGERI 21 SEMARANG
Authors: Andika Tri , Sumardiyani Listyaning , Nur Ardini Sukma , Lupiani Lilis Endah
Published: July 2023

This research is based on the potential that can be utilized from smartphone devices that can be developed to facilitate a teacher in terms of learning evaluation. This study aims to describe the implementation and response of practicing teachers to the use of Google Forms as an evaluation medium for learning English at SMPN 21 Semarang. The approach used is qualitative by using a qualitative descriptive method. The implementation of Google Form as an evaluation medium for learning English at SMPN 21 Semarang became the object of research, and practicing teachers of English subjects became the research subjects. The results of this study indicate that: (1) The implementation of the Google Form as an evaluation medium for learning English at SMPN 21 Semarang in general has been put to good use, since the preparation of the evaluation plan for learning outcomes, collecting data, conducting data verification, processing and analyzing data, providing interpretation and draw conclusions and follow-up from the teacher. (2) The teacher gave a good response based on aspects of effectiveness, time, cost, use, attractiveness, and benefits.Keyword: E-learning, Evaluation, Google Form Penelitian ini berdasarkan pada potensi yang dapat dimanfaatkan dari perangkat smartphone yang bisa dikembangkan untuk mempermudah seorang guru dalam hal evaluasi pembelajaran. Penelitian ini bertujuan untuk mendeskripsikan mengenai bagaimana pengimplementasian dan respon guru praktikan terhadap pemanfaatan Google Form sebagai media evaluasi pembelajaran Bahasa Inggris di SMPN 21 Semarang. Pendekatan yang digunakan adalah kualitatif dengan menggunakan metode deskriptif kualitatif. Implementasi Google Form sebagai media evaluasi pembelajaran Bahasa Inggris di SMPN 21 Semarang menjadi obyek penelitian, dan guru praktikan mata Bahasa Inggris menjadi subyek penelitian. Hasil penelitian ini menunjukkan bahwa: (1) Pengimplementasian Google Form sebagai media evaluasi pembelajaran Bahasa Inggris di SMPN 21 Semarang secara umum telah dimanfaatkan secara baik, sejak penyusunan rencana evaluasi hasil belajar, menghimpun data, melakukan verifikasi data, mengolah dan menganalisis data, memberikan interpretasi dan menarik kesimpulan serta adanya tindak lanjut dari guru. (2) Guru memberikan respon baik berdasarkan aspek - aspek efektivitas tenaga, waktu, biaya, penggunaan, kemenarikan, dan manfaat.Kata Kunci: E-learning, Evaluasi, Google Form
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA PADA TEMA LINGKUNGAN SAHABAT KITA DI KELAS V SD NEGERI 081235 SIBOLGA TAHUN PEMBELAJARAN 2022/2023
Authors: Pasaribu Helen Everiany , Anzelina Dewi , Sitepu Anton , Gaol Rumiris Lumban , Simarmata Ester Julinda , Sinaga Reflina
Published: July 2023

This Classroom Action Research (CAR) focuses on improving the critical thinking skills of fifth grade students at SD Negeri 081235 Sibolga for the 2022/2023 academic year by utilizing the Problem Based Learning learning model for subject 8 Our Friendly Environment. Two research cycles were conducted. 30 class V children of SD Negeri 081235 Sibolga were used as research subjects. Based on the research findings, it can be concluded that fifth grade students at SD Negeri 08235 Sibolga for the 2022/2023 academic year are increasingly proficient in using critical thinking when studying the sub-theme Changes in the learning environment 1 and the main theme Our Friends. Environment. Based on the research findings, 13 students or 43% obtained a complete score for cycle I, while 17 students or 57% did not complete with an average score of 70.41%. In cycle II there were 25 students who did not complete or 83% of the class, and 5 students who did not complete or 17% of the class with an average value of 83%. The action was abandoned in cycle II because it met the completeness requirements, so it was concluded that the learning topic Our Environment is a Friend in class V SD Negeri 081235 Sibolga is improved with a Problem Based Learning learning approach.Keyword: Critical Thinking Ability, Learning Model, Problem Based Learning Penelitian Tindakan Kelas (PTK) ini berfokus pada peningkatan kemampuan berpikir kritis siswa kelas V SD Negeri 081235 Sibolga Tahun Pelajaran 2022/2023 dengan memanfaatkan model belajar Problem Based Learning terhadap mata pelajaran 8 Lingkungan Sahabat Kita. Dua siklus penelitian dilakukan. 30 anak kelas V SD Negeri 081235 Sibolga dijadikan sebagai subjek penelitian. Berdasarkan temuan penelitian bisa diambil simpulan jika siswa kelas V SD Negeri 08235 Sibolga Tahun Pelajaran 2022/2023 semakin mahir menggunakan berpikir kritis ketika mempelajari subtema Perubahan lingkungan belajar 1 dan tema utama Teman Kita. Lingkungan. Berdasarkan temuan penelitian, 13 siswa atau 43% memperoleh nilai tuntas terhadap siklus I, sedangkan 17 siswa atau 57% tidak tuntas dengan nilai rata-rata 70,41%. Dalam siklus II ada 25 siswa yang tidak tuntas atau 83% kelas, dan 5 siswa yang tidak tuntas atau 17% kelas dengan nilai rata-rata 83%. Tindakan ditinggalkan dalam siklus II sebab memenuhi syarat ketuntasan, sehingga didapati kesimpulan jika topik pembelajaran Lingkungan Kita Sahabat di kelas V SD Negeri 081235 Sibolga ditingkatkan dengan pendekatan pembelajaran Problem Based Learning.Kata Kunci: Kemampuan Berpikir Kritis, Model Pembelajaran, Problem Based Learning
KAJIAN PENDEKATAN PEMBELAJARAN REALISTIC MATHEMATIC EDUCATION UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SD: ANALISIS LITERATUR
Authors: Laudia Stefanie Marla , Purwoko Budi
Published: July 2023

This study aims to determine the improvement of elementary students’ mathematical problem-solving skills taught by Realistic Mathematic Education approach. The research method is a literature review. Data collection in this research is done by searching journal through Google Scholar. Keywords used for journal searching are: Classroom Action Research, Realistic Mathematic Education, problem solving, and Mathematic elementary. Subsequently, 15 Classroom Action Research articles were selected and further analyzed. Based on the analysis result, it can be concluded that the Realistic Mathematics Education approach can enhance elementary school students' problem-solving skills in mathematics. The improvement in problem-solving skills ranged from a minimum of 11.67% to a maximum of 70%.Keyword: Realistic Mathematic Education, Problem Solving, Elementary Mathematic, Literature Review Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan pemecahan masalah matematika siswa SD yang diajarkan melalui Pendekatan Matematika Realistik. Metode penelitian yang digunakan adalah analisis literatur. Pengumpulan data dalam penelitian ini dilakukan dengan menelusuri jurnal melalui Google Cendekia. Kata kunci yang digunakan untuk penelusuran jurnal adalah: Penelitian Tindakan Kelas, Pendekatan Matematika Realistik, kemampuan pemecahan masalah, dan matematika SD. Kemudian terpilihlah 15 artikel Penelitian Tindakan Kelas yang dianalisis lebih lanjut. Berdasarkan hasil analisis dari 15 artikel, dapat disimpulkan bahwa Pendekatan Matematika Realistik dapat meningkatkan kemampuan pemecahan masalah matematika SD. Peningkatan kemampuan pemecahan masalah bervariasi dari yang terendah 11,67% sampai yang tertinggi 70%.Kata Kunci: Pendekatan Matematika Realistik, Kemampuan Pemecahan Masalah, Matematika SD, Kajian Literatur
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF MODEL THINK PAIR SHARE BERBASIS ARTICULATE STORYLINE PADA TEMA 6 SUBTEMA 1 KELAS IV SD NEGERI 105282 GALANG
Authors: Ricca Andar , Simanihuruk Lidia
Published: July 2023

This study aims to determine the level of feasibility, practicality, and effectiveness of the interactive learning media Think Pair Share model based on Articulate Storyline in Theme 6 Subtheme 1 Learning 3 Class IV-B SD Negeri 105382 Galang T.A 2022/2023. This type of research is R&D with the ADDIE development model. Data collection techniques in this study consisted of observation and interviews, questionnaires and tests. The instruments used in this study included interview instruments, expert instruments (questions, tests, media, and materials), practical instruments (teacher and student response questionnaires), and learning achievement tests. Data analysis techniques used in this research are qualitative data and quantitative data. The results of this study indicate that the interactive learning media Think Pair Share model based on Articuate Storyline on theme 6 subtheme 1 learning 3 is declared feasible, practical, and effective for use in learning. Based on the feasibility results, the product gets a percentage of 75% and is included in the feasible category. Product practicality results get a percentage of 94% and are included in the very practical category. Product effectiveness results get a percentage of 69% and are included in the effective category.Keyword: Interactive Media, TPS, Articulate Storyline Penelitian ini bertujuan untuk mengetahui tingkat kelayakan, praktikalitas, dan keefektifan dari media pembelajaran interaktif model Think Pair Share berbasis Articulate Storyline pada Tema 6 Subtema 1 Pembelajaran 3 Kelas IV-B SD Negeri 105382 Galang T.A 2022/2023. Jenis penelitian ini adalah R&D dengan model pengembangan ADDIE. Teknik pengumpulan data dalam penelitian ini terdiri atas observasi dan wawancara, angket, dan tes. Adapun instrumen yang digunakan dalam penelitian ini meliputi instrumen wawancara, instrumen ahli (angket, tes, media, dan materi), instrumen praktikalitas (angket respon guru dan siswa), dan tes hasil belajar. Teknik analisis data yang digunakan dalam penelitian ini adalah data kualitatif dan data kuantitatif. Hasil penelitian ini menunjukkan bahwa media pembelajaran interaktif model Think Pair Share berbasis Articuate Storyline pada tema 6 subtema 1 pembelajaran 3 dinyatakan layak, praktis, dan efektif digunakan dalam pembelajaran. Berdasarkan hasil kelayakan produk mendapatkan persentase 75% dan termasuk kategori layak. Hasil praktikalitas produk mendapatkan persentase 94% dan termasuk kategori sangat praktis. Hasil efektifitas produk mendapatkan persentase 69% dan termasuk kategori efektif.Kata Kunci: Media Interaktif, TPS, Articulate Storyline
UPAYA MENINGKATKAN HASIL BELAJAR MATEMATIKA PADA MATERI PECAHAN MELALUI PERMAINAN MONOPOLI PECAHAN
Authors: Mailani Elvi
Published: July 2023

Penelitian ini bertujuan untuk meningkatkan kemampuan matematika siswa pada materi pecahan siswa kelas IV SDS Inti Nusantara kota Tebing Tinggi. Penelitian ini adalah penelitian tindakan kelas. Penelitian ini dilaksanakan sebanyak 2 siklus. Subjek pada penelitian ini berjumlah 32 siswa. Analisis data pada penelitian ini dikumpulkan melalui kegiatan unjuk kerja, lembar observasi, dan tes. Pada kegiatan pra Siklus rata rata kemampuan siswa sebesar 44,7%. Setelah dilakukan tindakan pada siklus I, rata-rata kemampuan menjadi 72,8%. Pada siklus II, rata-rata kemampuan siswa meningkat lagi mencapai 91,6%. Terjadi peningkatan 46,9 % dari pra siklus sampai dengan siklus II terhadap kemampuan matematika pada materi pecahan siswa kelas IV SDS Inti Nusantara  kota tebing Tinggi dan dengan demikian maka penelitian ini dikatakan berhasil.   Kata Kunci : hasil belajar , monopoli pecahan, matematika
PENINGKATAN KEMAMPUAN GURU BAHASA INGGRIS DALAM MERANCANG RPP KURIKULUM 2013 MELALUI KEGIATAN BIMBINGAN BERKELANJUTAN
Authors: Hutagaol Sinur
Published: July 2023

Abstract : Improving the Ability of English Language Teachers in DesigningRPP 2013 Curriculum Through Continuous Guidance Activities. This studyaims to improve the ability of teachers in Tebingtinggi City 5 Middle School inpreparing learning implementation plans (RPP) using the 2013 curriculum throughmentoring activities. The subject of this study is an English teacher who teaches inthe State Middle School 5 in Tebingtinggi in the 2016/2017 learning year, whichamounts to 5 teachers. This study uses qualitative descriptive analysis techniques.Data analysis in this study was collected through performance activities, observationsheets, interviews and documentation. Continuous guidance activities carried out onEnglish language teachers in the 2016/2017 learning year conducted at Tebingtinggi5 Public Middle School through continuous guidance activities can improve theability of teachers to prepare lesson plans using the 2013 curriculum. This can beseen from the results of assessments and observations made by researchers if beforethe assistance is carried out the number of teachers who are able to make lessonplans using the 2013 curriculum can be said to be nonexistent then after the secondcycle, all 5 English teachers have been able to prepare lesson plans using the 2013curriculum.Keywords : RPP, 2013 Curriculum, Sustainable GuidanceAbstrak : Peningkatan Kemampuan Guru Bahasa Inggris Dalam MerancangRPP Kurikulum 2013 Melalui Kegiatan Bimbingan Berkelanjutan. Penelitianini bertujuan untuk meningkatkan kemampuan guru-guru SMP Negeri 5 kotaTebingtinggi dalam menyusun rencana pelaksanaan pembelajaran ( RPP )menggunakan kurikulum 2013 melalui kegiatan pendampingan. Yang menjadisubjek pada penelitian ini adalah guru bahasa Inggris yang mengajar di SMP Negeri5 kota Tebingtinggi tahun pembelajaran 2016/2017 yang berjumlah 5 guru.Penelitian ini menggunakan teknik analisis deskriptif kualitatif. Analisis data padapenelitian ini dikumpulkan melalui kegiatan unjuk kerja, lembar observasi,wawancara serta dokumentasi. Kegiatan bimbingan berkelanjutan yang dilakukanterhadap guru bahasa Inggris tahun pembelajaran 2016/2017 yang dilakukan di SMPNegeri 5 kota Tebingtinggi melalui kegiatan bimbingan berkelanjutan dapatmeningkatkan kemampuan guru dalam menyusun RPP menggunakan kurikulum2013. Hal ini dapat terlihat dari hasil penilaian dan observasi yang dilakukan olehpeneliti jika sebelum pendampingan dilakukan jumlah guru yang mampu membuatRPP dengan menggunakan kurikulum 2013 bisa dikatakan tidak ada sama sekalimaka setelah siklus II dilaksanakan seluruh guru bahasa Inggris sebanyak 5 gurutelah mampu menyusun RPP dengan menggunakan kurikulum 2013.Kata Kunci : RPP, Kurikulum 2013, Bimbingan Berkelanjutan
KEPEMIMPINAN KEPALA MADRASAH DALAM PERSPEKTIF MANAJEMEN BERBASIS SEKOLAH SEBAGAI AKSES PENDIDIKAN BERKUALITAS DI ERA INDUSTRI REVOLUSI 4.0
Authors: Syakur Achmad , Utomo Sigit Tri
Published: July 2023

Education in the era of the industrial revolution 4.0 should form people who are dedicated to the system, but the education system in several educational institutions in reality there is still an opportunity for someone to take actions that are not in accordance with the regulations made by the educational institution such as professional and quality institutional management. , thus providing the impact of changes in an educational process system. This quality education process, it has implications for the direction and progress of an educational institution. This is where the role of a madrasa principal plays an important role. The data collection method in this study uses library research. In this case, it is a variant of qualitative research, data collection can use observational interviews and documentation. At this stage, the researcher tries to select data (books) that have relevance to the leadership of the madrasah principal in the perspective of MBS as access to quality education in the era of the industrial revolution 4.0. In this paper, in analyzing this paper with a hermeneutic approach, the author describes behind the text there is a context meaning or behind the explicit meaning, there is an explicit meaning if interpreted literally it can be interpreted as interpretation or interpretation. This method step is intended to capture the meaning, values and intentions of the madrasa principal's leadership in the MBS perspective as access to quality education in the era of the industrial revolution 4.0. Then the author also uses synthetic analysis which means the stages of an object of scientific study that link an articulation of one meaning with another meaning which is then found a knowledge with a new articulation in the form of the leadership of the head of the madrasah in the perspective of MBS as access to quality education in the era of the industrial revolution 4.0.

Keywords: Leadership of Madrasah Principals, SBM Perspective, Quality Education, Industrial Era 4.
KEARIFAN LOKAL KEMPONAN PADA MASYARAKAT MELAYU DESA SUNGAI KUNYIT LAUT KABUPATEN MEMPAWAH DALAM PANDANGAN AQIDAH DAN AKHLAK ISLAM
Authors: Miranda Siska , Rianawati Rianawati , Susanto Rizki
Published: July 2023

Abstract: The purpose of this study was to examine the local wisdom of kemponan which is still carried out by the Malay community. Kemponan is an expression related to the activity of offering food and drink to other people who have a causal bond when they refuse the offer. This study uses qualitative research to gather information from the community, religious, customary, and community leaders who still apply "kemponan" in their daily lives. The Kemponan which is considered mystical is then analyzed in terms of Islamic aqidah and morals to find the cultural link between the culture and the Muslim community who carry it out. Keywords: local wisdom, kemponan, and Islamic worldview
URGENSI PERLINDUNGAN DAN PENDIDIKAN ANAK DI INDONESIA: PERSPEKTIF PENDIDIKAN ISLAM
Authors: Mansir Firman -
Published: July 2023

The purpose of this study was to find out about the importance of child protection and education from an Islamic perspective. The method in this study uses the method of literature study or literature study sourced from relevant library materials with a focus on research topics. The literature analyzed in this article is obtained from several national journals and several books that are in line with the problem of children's education from an Islamic perspective, then after the required data is deemed sufficient, data analysis is carried out and followed by a conclusion. This study shows that the development of children's potential can be done through an Islamic education approach. Thus, Islamic education in the future needs to focus on and contribute greatly to the protection and education of children. Not only normative with existing arguments but also needs to give a special role so that Indonesian children do not experience trauma and mental decline. This is because the growth and development of children are strongly influenced by the education factor received from an early age.Keywords: Child Protection, Child Education, Islamic Education.
High Quality Multi-Zone and 3D CFD Model of Combustion in Marine Diesel Engine Cylinder
Authors: Cuper-Przybylska Dominika , Nguyen Van Nhanh , Nam Cao Dao , Kowalski Jerzy
Published: July 2023

The paper presents a 3D model of the processes taking place in the cylinder of a large 4-stroke marine engine. The model is based on CFD calculations performed on the moving mesh. The modelling range includes the full duty cycle (720° crankshaft position) and the complete geometry of the cylinder with inlet and exhaust ducts. The input data, boundary conditions and validation data were obtained by direct measurements on the real object. Fuel injection characteristics were obtained by Mie scattering measurements in a fixed-volume chamber. The modelling results have been validated in terms of the pressure characteristics of the engine’s cylinder within the entire range of its loads. The mean error did not exceed 1.42% for the maximum combustion pressure and 1.13% for the MIP (Mean Indicated Pressure). The model was also positively validated in terms of the O2 and NOx content of the exhaust gas. The mean error in this case was 1.2% for NOx fractions in the exhaust gas and 0.4% for O2 fractions. The complete model data has been made available in the research data repository on an open access basis.
Health Monitoring of a Compression Ignition Engine Fed with Different Low-Sulphur Marine Fuels by Endoscopic Image Processing and Analysis
Authors: Korczewski Zbigniew
Published: July 2023

This article characterises the methodology for the endoscopic testing of a laboratory diesel engine used for testing marine fuels. The ‘Shadow’ measurement method used in the XLG3 type EVEREST digital endoscope, for quantitative and qualitative identification of detected surface defects, was approximated. Representative endoscopic images of the elements limiting the working space of the research engine are demonstrated, having been recorded during the usable quality testing of newly produced, low-sulphur marine fuels, so-called ‘modified fuels’. The main purpose of the endoscopic examinations was the final verification of the tested fuel’s suitability for feeding full-size marine engines.
Evaluation of Geometrical Influence on the Hydrodynamic Characteristics and Power Absorption of Vertical Axisymmetric Wave Energy Converters in Irregular Waves
Authors: Zhang Wanchao , Zhu Yang , Liu Shuxu , Wang Jianhua , Zhang Wentian
Published: July 2023

To obtain the mechanical energy of waves from arbitrary directions, the vibration absorbers of wave energy converters (WEC) are usually vertically axisymmetric. In such case, the wave-body interaction hydrodynamics is an essential research topic to obtain high-efficiency wave energy. In this paper, a semi-analytical method of decomposing the complex axisymmetric boundary into several ring-shaped stepped surfaces based upon the boundary approximation method (BAM) is introduced and examined. The hydrodynamic loads and parameters, such as the wave excitation forces, added mass and radiation damping of the vertical axisymmetric oscillating buoys, can then be achieved by using the new boundary discretisation method. The calculations of the wave forces and hydrodynamic coefficients show good convergence with the number of discretisation increases. Comparison between the constringent results and the results of the conventional method also verifies the feasibility of the method. Then, simulations and comparisons of the hydrodynamic forces, motions and wave power conversions of the buoys with series draught and displacement ratios in regular and irregular waves are conducted. The calculation results show that the geometrical shape has a great effect on the hydrodynamic and wave power conversion performance of the absorber. In regular waves, though the concave buoy has the lowest wave conversion efficiency, it has the largest frequency bandwidth for a given draught ratio, while in irregular waves, for a given draught ratio, the truncated cylindrical buoy has the best wave power conversion, and for a given displacement of the buoy, the concave buoy shows the best wave power conversion ability.
The Representation of Culture in “Bumi Manusia” Novel by Pramoedya Ananta Toer
Authors: Perangin-angin Alemina Br. , Andayani Widya , Brahmana Reja Aprilla , Putri Mellya Miranda , Khoir M. Sya’banul
Published: July 2023

Critical discourse analysis is a view of language in discourse analysis that views powers as always involved in forming subjects represented in language. The AWK model used in this paper is Norman Fairclough’s critical discourse analysis. Critical discourse analysis, which generally analyzes media texts, can also be used to analyze literary works, including novels. The novel analyzed by Norman Fairclough’s discourse analysis is the novel Bumi Manusia by Manusiaya Ananta Toer. Norman Fairclough’s discourse analysis examines text, discourse practice, and sociocultural practice. The three aspects of Norman Fairclough’s discourse analysis can be answered through the descriptive method text section the researcher can find three basic elements in the Norman Fairclough model, namely elements of representation, relations, and identity in the novel Bumi Manusia. Meanwhile, this paper will only discuss one element, namely representation. The result of this research is that culture is found in the text of the novel Bumi Manusia, in the form of daily behavior, language, clothes, to the names that appear in the text of the novel. In the text of the Bumi Manusia novel, there are also several cultures, not only Indonesian culture but, there is also Dutch culture by the contents of the story or synopsis of the novel describes indigenous life side by side with the Dutch.
The Fauna Lexicon in Aceh Proverb: Ecolinguistic Study
Authors: Pasaribu Gumarpi Rahis , Widayati Dwi , Mbete Aron Meko , Dardanila Dardanila
Published: July 2023

The reciprocal relationship between humans and humans, humans and the nature around them, produces a variety of languages. Ecolinguistics is needed in studying aceh language phenomena. This study aims to describe the meaning, function, and form of the fauna lexicon in the culture of the people of Aceh. This research is descriptive-qualitative in nature. This research data collection technique consists of interview techniques and observation techniques. Interview techniques were used to obtain data on the meaning and function of fauna in the culture of the people of Aceh. While observation techniques are used to obtain data on fauna forms in the culture of the people of Aceh. Current facts show that the lexicon of fauna is still used by parents when advising the younger generation, and they cannot understand the meaning of the advice. This is caused by environmental changes and the times that affect the younger generation’s mindset. The researcher collected a list of fauna lexicons in the Acehnese language and classified them into verb and noun classes.