bluuebunny/crossref_metadata_2025 huggingface dataset:
Motor Function Relating to the Accuracy of Self-Overestimation Error in Community-Dwelling Older Adults
Authors: Kawasaki Tsubasa , Tozawa Ryosuke
Published: November 2020

Background: Older adults often overestimate their motor performance, which represents a serious safety hazard. The cause of this self-overestimation is to date, not yet fully established. Thus, the present study aimed to reveal the factors associated with self-overestimation by focusing on motor function.

Methods: This study included 105 community-dwelling older adults [20 males, median (25, 75 percentile) age: 73.00 (69.50, 77.50)]. Participants were assessed for errors in their self-estimation using a two-step test. They estimated the two-step distance that could be reached with maximum effort. Thereafter, they performed the actual two-step action. Participants were comprehensively assessed for motor function by various tests (i.e., 10-meter Walking Test, Timed Up and Go Test, postural stability, and muscle strength). They were then divided into two groups (the self-underestimation or self-overestimation group) and their motor performances were compared. Multiple linear regression analysis was then utilized to investigate the relationship between self-estimation error and motor function.

Results: Significant differences were found between the two groups regarding age, weight, actual two-step distance, and the time required for the Timed Up and Go Test and 10-meter Walking Test (p < 0.05). The regression analysis showed that self-estimation error was significantly related to the result of the 10-meter Walking Test (beta = 0.24, p = 0.011).

Conclusions: The self-overestimation of motor performance, which is likely to lead to several dangers (i.e., falling or obstacle collision), was related to walking ability. Consequently, the results showed that the 10-meter Walking Test would assist in detecting the self-overestimation of motor performance.
Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism?
Authors: Brandalise Federico , Ratto Daniela , Leone Roberta , Olivero Federico , Roda Elisa , Locatelli Carlo Alessandro , Grazia Bottone Maria , Rossi Paola
Published: November 2020

In the last decades, increasing evidence has revealed that a large number of channel protein and ion pumps exhibit impaired expression in cancers. This dysregulation is responsible for high proliferative rates as well as migration and invasiveness, reflected in the recently coined term oncochannelopathies. In glioblastoma (GBM), the most invasive and aggressive primary brain tumor, GBM cells modify their ionic equilibrium in order to change their volume as a necessary step prior to migration. This mechanism involves increased expression of BK channels and downregulation of the normally widespread Kir4.1 channels, as noted in GBM biopsies from patients. Despite a large body of work implicating BK channels in migration in response to an artificial intracellular calcium rise, little is known about how this channel acts in GBM cells at resting membrane potential (RMP), as compared to other channels that are constitutively open, such as Kir4.1. In this review we propose that a residual fraction of functionally active Kir4.1 channels mediates a small, but continuous, efflux of potassium at the more depolarized RMP of GBM cells. In addition, coinciding with transient membrane deformation and the intracellular rise in calcium concentration, brief activity of BK channels can induce massive and rapid cytosolic water loss that reduces cell volume (cell shrinkage), a necessary step for migration within the brain parenchyma.
Bioactive Compounds for the Management of Hypertriglyceridemia: Evidence From Clinical Trials and Putative Action Targets
Authors: Schiano Elisabetta , Annunziata Giuseppe , Ciampaglia Roberto , Iannuzzo Fortuna , Maisto Maria , Tenore Gian Carlo , Novellino Ettore
Published: November 2020

Hypertriglyceridemia refers to the presence of elevated concentrations of triglycerides (TG) in the bloodstream (TG >200 mg/dL). This lipid alteration is known to be associated with an increased risk of atherosclerosis, contributing overall to the onset of atherosclerotic cardiovascular disease (CVD). Guidelines for the management of hypertriglyceridemia are based on both lifestyle intervention and pharmacological treatment, but poor adherence, medication-related costs and side effects can limit the success of these interventions. For this reason, the search for natural alternative approaches to reduce plasma TG levels currently represents a hot research field. This review article summarizes the most relevant clinical trials reporting the TG-reducing effect of different food-derived bioactive compounds. Furthermore, based on the evidence obtained fromin vitrostudies, we provide a description and classification of putative targets of action through which several bioactive compounds can exert a TG-lowering effect. Future research may lead to investigations of the efficacy of novel nutraceutical formulations consisting in a combination of bioactive compounds which contribute to the management of plasma TG levels through different action targets.
Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer
Authors: Tang Hui , Zheng Ji , Bai Xuan , Yue Ke-Lin , Liang Jian-Hua , Li Dan-Yang , Wang Lin-Ping , Wang Jin-Li , Guo Qiang
Published: November 2020

Angiogenesis and the tumor microenvironment (TME) play important roles in tumorigenesis. Forkhead box Q1 (FOXQ1) is a well-established oncogene in multiple tumors, including colorectal cancer (CRC); however, whether FOXQ1 contributes to angiogenesis and TME modification in CRC remains largely uncharacterized. Here, we demonstrate an essential role of FOXQ1-induced angiogenesis and macrophage recruitment in CRC that is related to its ability to promote the migration of endothelial cells and macrophages through activation of the EGF/PDGF pathway and the Twist1/CCL2 axis. We also provide evidence showing that the clinical significance between FOXQ1, Twist1, CCL2, and macrophage infiltration is associated with reduced 8-year survival in CRC patients. Our findings suggest FOXQ1 plays critical roles in the malignancy and progression of CRC, Therefore, FOXQ1 may serve as a therapeutic target for inhibiting angiogenesis and reducing macrophage recruitment in CRC.
Nuclear Magnetic Resonance-Based Metabolomic Analysis of the Anticancer Effect of Metformin Treatment on Cholangiocarcinoma Cells
Authors: Zhang Jin , Hang Caihua , Jiang Ting , Yi Shenghui , Shao Wei , Li Wengang , Lin Donghai
Published: November 2020

Metformin is a widely prescribed anti-diabetes drug with potential utilities for cancer therapies. Several studies have related metformin to the reduced risk of cholangiocarcinoma (CCA), highlighting its potentialities for the treatments of CCA. However, the underlying molecular mechanisms remain elusive. Here, we demonstrated that metformin treatment could inhibit proliferations of the human CCA cell lines Mz-ChA-1 and QBC939 in dose-dependent manners. The NMR-based metabonomic analyses showed distinct discriminations between the metformin-treated (Met) and control (Ctrl) groups of both CCA cells. Characteristic metabolites were identified by a combination of multivariate statistical analysis of 1D 1H-NMR spectral data and the pair-wise t-test of metabolite levels. We then identified four significantly altered metabolic pathways based on the characteristic metabolites, including glucose metabolism, oxidative stress-related metabolism, energy metabolism, and amino acids metabolism. Comparing CCA cells with normal human umbilical vein endothelial cells (HUVECs), we found that metformin treatment profoundly promoted glycolysis and specifically increased the levels of BCAAs and UDP-GlcNAc, implying the occurrence of autophagy and cell cycle arrest in metformin-treated CAA cells. This work provides a mechanistic understanding of the anticancer effect of metformin treatment on CAA cells, and is beneficial to further developments of metformin as an anticancer drug.
Does EIF2S3 Retrogene Activation Regulate Cancer/Testis Antigen Expression in Human Cancers?
Authors: Rohozinski Jan , Edwards Creighton L.
Published: November 2020

Cancer/Testis (C/T) antigens are a group of antigens, expressed in almost all types of cancers, which can elicit an immune response in patients whose cancers express these antigens. They are currently of great interest as targets for the development of cancer biomarkers and the creation of immunotherapies that directly target tumors in patients. Currently there are 280 C/T antigens and their variants listed on the C/T antigen data base. All known C/T antigens are encoded for by genes which are normally only expressed in the male testis; specifically during the process of spermatogenesis. They are therefore only expressed in germ cells that are in the process of differentiating into sperm. Expression of C/T antigens in tumors is thus a biological anomaly as, with the exception of germ cell tumors, cancers arise from somatic tissues which are not known to express any of the genes specifically involved in spermatogenesis. How and why C/T antigens are expressed in tumors remains an enigma. In this paper we present a hypothesis which proposes a mechanism for the activation of C/T antigen encoding genes in tumors. We propose that aberrant activation of the human autosomal retrogene, EIF2S3B, which regulates initiation and maintenance of spermatogenesis in males, is responsible for C/T expression. Because both male and females have tumors that express C/T antigens activation of spermatogenesis genes in tumors must involve a non-sex specific pathway. This can be explained by the copy number of EIF2S3 genes uniquely present within the human genome.
Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease
Authors: Suresh Diwakar , Srinivas Akshatha N. , Kumar Divya P.
Published: November 2020

Hepatocellular Carcinoma (HCC) is a highly aggressive cancer with mortality running parallel to its incidence and has limited therapeutic options. Chronic liver inflammation and injury contribute significantly to the development and progression of HCC. Several factors such as gender, age, ethnicity, and demographic regions increase the HCC incidence rates and the major risk factors are chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV), carcinogens (food contaminants, tobacco smoking, and environmental toxins), and inherited diseases. In recent years evidence highlights the association of metabolic syndrome (diabetes and obesity), excessive alcohol consumption (alcoholic fatty liver disease), and high-calorie intake (nonalcoholic fatty liver disease) to be the prime causes for HCC in countries with a westernized sedentary lifestyle. HCC predominantly occurs in the setting of chronic liver disease and cirrhosis (80%), however, 20% of the cases have been known in patients with non-cirrhotic liver. It is widely believed that there exist possible interactions between different etiological agents leading to the involvement of diverse mechanisms in the pathogenesis of HCC. Understanding the molecular mechanisms of HCC development and progression is imperative in developing effective targeted therapies to combat this deadly disease. Noteworthy, a detailed understanding of the risk factors is also critical to improve the screening, early detection, prevention, and management of HCC. Thus, this review recapitulates the etiology of HCC focusing especially on the nonalcoholic fatty liver disease (NAFLD)- and alcoholic fatty liver disease (AFLD)-associated HCC.
Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
Authors: Li Songtao , Qian Qianyu , Ying Na , Lai Jianfei , Feng Luyan , Zheng Sitong , Jiang Fusheng , Song Qing , Chai Hui , Dou Xiaobing
Published: November 2020

Background: Salvianolic acid A (Sal A), a natural polyphenol compound extracted from Radix Salvia miltiorrhiza (known as Danshen in China), possesses a variety of potential pharmacological activities. The aim of this study is to determine mechanisms of hepatoprotective effects of Sal A against lipotoxicity both in cultured hepatocytes and in a mouse model of fatty liver disease.

Methods: High-fat and high-carbohydrate diet (HFCD)-fed C57BL/6J mice were employed to establish hepatic lipotoxicity in a mouse model. Two doses of Sal A were administered every other day via intraperitoneal injection (20 and 40 mg/kg BW, respectively). After a 10-week intervention, liver injury was detected by immunohistochemical and biochemical analyses. For in vitro studies, we used HepG2, a human hepatoma cell line, and exposed them to palmitic acid to induce lipotoxicity. The protective effects of Sal A on palmitic acid-induced lipotoxicity were examined in Sal A-pretreated HepG2 cells.

Results: Sal A treatments attenuated body weight gain, liver injury, and hepatic steatosis in mice exposed to HFCD. Sal A pretreatments ameliorated palmitic acid-induced cell death but did not reverse effects of HFCD- or palmitate-induced activations of JNK, ERK1/2, and PKA. Induction of p38 phosphorylation was significantly reversed by Sal A in HFCD-fed mice but not in palmitate-treated HepG2 cells. However, Sal A rescued hepatic AMP-activated protein kinase (AMPK) suppression and sirtuin 1 (SIRT1) downregulation by both HFCD feeding in mice and exposure to palmitate in HepG2 cells. Sal A dose-dependently up-regulated p-AMPK and SIRT1 protein levels. Importantly, siRNA silencing of either AMPK or SIRT1 gene expression abolished the protective effects of Sal A on lipotoxicity. Moreover, while AMPK silencing blocked Sal A-induced SIRT1, silencing of SIRT1 had no effect on Sal A-triggered AMPK activation, suggesting SIRT1 upregulation by Sal A is mediated by AMPK activation.

Conclusion: Our data uncover a novel mechanism for hepatoprotective effects of Sal A against lipotoxicity both in livers from HFCD-fed mice and palmitic acid-treated hepatocytes.
Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso
Authors: Tibiri André , Boria Sébastien , Traoré Tata Kadiatou , Ouédraogo Noufou , Nikièma Aude , Ganaba Souleymane , Compaoré Jean-Marie , Ouédraogo Issiaka , Guissou Innocent Pierre , Carraz Maëlle
Published: November 2020

Liver disease is highly prevalent in Africa, especially in the western African country Burkina Faso, due to the presence of multiple biological and chemical aggressors of the liver. Furthermore, diagnosis and appropriate care for liver disease are uneven and usually insufficient. This drives local communities to turn to folk medicine based on medicinal plants from healers. Small scale, ethnopharmacological studies on reputed hepatoprotective plants have been carried out in defined regions worldwide, but so far, no study has been carried out on a countrywide scale. Therefore, we have explored traditional healers’ practices in all thirteen regions of Burkina Faso. We interviewed 575 healers and we compiled a database with 2,006 plant entries. Here, we report results on liver nosology, liver pathologies, medicinal plants used for liver disease, and traditional practices through the lens of Burkinabe healers. Our goal was to give a full inventory of medicinal plants used to treat liver disease and to determine if there was consensus on the use of specific plants for specific symptoms. Analysis of the medicinal plants in use across the whole country provides local communities with a wider evidence base to determine which plants may be more effective in treating liver disease and could provide the scientific community, with a shortlist of plants suitable for chemical and pharmacological investigation to validate the plants’ therapeutic role.
Analysis of the Costs Associated With the Elective Evaluation of Patients Labelled as Allergic to Beta-Lactams or Nonsteroidal Antiinflamatory Agents
Authors: Sobrino-García Miriam , Moreno Esther M. , Muñoz-Bellido Francisco J. , Gracia-Bara Maria T. , Laffond Elena , Doña Inmaculada , Martín Cristina , Macías Eva M. , de Arriba Sonia , Campanón Valle , Gallardo Alicia , Dávila Ignacio
Published: November 2020

Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive. We aimed to analyze different studies of the costs of drug hypersensitivity assessment.

Methods: A bibliographic search on studies regarding this issue was performed, including the available scientific evidence up to June 2020. We searched three databases with terms related to costs and allergy testing in drug hypersensitivity reactions.

Results: Our search revealed 1,430 publications, of which 20 met the inclusion criteria. In the manuscript, prospective studies evaluating the costs of the evaluation of patients with suspected allergy to beta-lactams or non-steroidal anti-inflammatory drugs are analyzed. Also, comment is made on the costs associated with incorrect labeling as non-steroidal anti-inflammatory drug or penicillin hypersensitivity.

Conclusions: Taking all costs into account, the study of drug hypersensitivity is not expensive, particularly considering the economic and clinical consequences of labeling a patient with hypersensitivity to drugs.
Deletion of Protocadherin Gamma C3 Induces Phenotypic and Functional Changes in Brain Microvascular Endothelial Cells In Vitro
Authors: Gabbert Lydia , Dilling Christina , Meybohm Patrick , Burek Malgorzata
Published: November 2020

Inflammation of the central nervous system (CNS) is associated with diseases such as multiple sclerosis, stroke and neurodegenerative diseases. Compromised integrity of the blood-brain barrier (BBB) and increased migration of immune cells into the CNS are the main characteristics of brain inflammation. Clustered protocadherins (Pcdhs) belong to a large family of cadherin-related molecules. Pcdhs are highly expressed in the CNS in neurons, astrocytes, pericytes and epithelial cells of the choroid plexus and, as we have recently demonstrated, in brain microvascular endothelial cells (BMECs). Knockout of a member of the Pcdh subfamily, PcdhgC3, resulted in significant changes in the barrier integrity of BMECs. Here we characterized the endothelial PcdhgC3 knockout (KO) cells using paracellular permeability measurements, proliferation assay, wound healing assay, inhibition of signaling pathways, oxygen/glucose deprivation (OGD) and a pro-inflammatory cytokine tumor necrosis factor alpha (TNFα) treatment. PcdhgC3 KO showed an increased paracellular permeability, a faster proliferation rate, an altered expression of efflux pumps, transporters, cellular receptors, signaling and inflammatory molecules. Serum starvation led to significantly higher phosphorylation of extracellular signal-regulated kinases (Erk) in KO cells, while no changes in phosphorylated Akt kinase levels were found. PcdhgC3 KO cells migrated faster in the wound healing assay and this migration was significantly inhibited by respective inhibitors of the MAPK-, β-catenin/Wnt-, mTOR- signaling pathways (SL327, XAV939, or Torin 2). PcdhgC3 KO cells responded stronger to OGD and TNFα by significantly higher induction of interleukin 6 mRNA than wild type cells. These results suggest that PcdhgC3 is involved in the regulation of major signaling pathways and the inflammatory response of BMECs.
Modulation of Autophagy by SARS-CoV-2: A Potential Threat for Cardiovascular System
Authors: Randhawa Puneet Kaur , Scanlon Kaylyn , Rappaport Jay , Gupta Manish K.
Published: November 2020

Recently, we have witnessed an unprecedented increase in the number of patients suffering from respiratory tract illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 virus is a single-stranded positive-sense RNA virus with a genome size of ~29.9 kb. It is believed that the viral spike (S) protein attaches to angiotensin converting enzyme 2 cell surface receptors and, eventually, the virus gains access into the host cell with the help of intracellular/extracellular proteases or by the endosomal pathway. Once, the virus enters the host cell, it can either be degradedviaautophagy or evade autophagic degradation and replicate using the virus encoded RNA dependent RNA polymerase. The virus is highly contagious and can impair the respiratory system of the host causing dyspnea, cough, fever, and tightness in the chest. This disease is also characterized by an abrupt upsurge in the levels of proinflammatory/inflammatory cytokines and chemotactic factors in a process known as cytokine storm. Certain reports have suggested that COVID-19 infection can aggravate cardiovascular complications, in fact, the individuals with underlying co-morbidities are more prone to the disease. In this review, we shall discuss the pathogenesis, clinical manifestations, potential drug candidates, the interaction between virus and autophagy, and the role of coronavirus in exaggerating cardiovascular complications.
Ascorbate-Mediated Modulation of Cadmium Stress Responses: Reactive Oxygen Species and Redox Status in Brassica napus
Authors: Jung Ha-il , Lee Bok-Rye , Chae Mi-Jin , Lee Eun-Jin , Lee Tae-Gu , Jung Goo-Bok , Kim Myung-Sook , Lee Jinwook
Published: November 2020

The role of ascorbate (AsA) in antioxidant defense system-associated resistance to cadmium (Cd) in oilseed rape plants has not yet been clearly demonstrated. The present study investigated the critical role of exogenous AsA on the physiological and biochemical responses of reactive oxygen species (ROS) and antioxidant scavenging defense systems in oilseed rape (Brassica napusL. cv. Tammi) seedlings exposed to Cd. Cd (10 μM) treatment led to significant reductions in plant growth; increases in the levels of superoxide anion radical, hydrogen peroxide, and malondialdehyde; and increases in Cd uptake and accumulation by the roots and shoots in hydroponically grown 10-day-old seedlings. Moreover, it reduced AsA content and AsA redox ratios, which have been correlated with reductions in glutathione (GSH) and/or nicotinamide adenine dinucleotide phosphate (NADPH) redox status. However, exogenously applying AsA to Cd-exposed seedlings decreased Cd-induced ROS, improved antioxidant defense systems by increasing AsA, GSH, and NADPH contents, and increased Cd uptake and accumulation in both roots and shoots of the plants. These results provided evidence that the enhancement in AsA redox status can be linked to an increase in the GSH and/or NADPH redox ratios through the induction of the AsA–GSH–NADPH cycle. Thus, these results suggest that exogenous AsA application to oilseed rape seedlings under Cd stress might alleviate the overall Cd toxicity by regulating the homeostasis of the AsA–GSH–NADPH cycle, which reestablishes the steady-state cellular redox status.
Acupuncture for Improving Cognitive Impairment After Stroke: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhou Liang , Wang Yao , Qiao Jun , Wang Qing Mei , Luo Xun
Published: November 2020

Objective: This meta-analysis evaluated the efficacy of acupuncture in improving cognitive impairment of post-stroke patients.

Design: Randomized controlled trials (RCTs) investigating the effects of acupuncture compared with no treatment or sham acupuncture on post-stroke cognitive impairment (PSCI) before December 2019 were identified from databases (PubMed, EMBASE, Ovid library, Cochrane Library, Chinese National Knowledge Infrastructure, VIP Chinese Periodical Database, Wanfang Database, and SinoMed). The literature searching and data extracting were independently performed by two investigators. Study quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analyses were performed for the eligible RCTs with Revman 5.3 software.

Results: Thirty-seven RCTs (2,869 patients) were included in this meta-analysis. Merged Random-effects estimates of the gain of MMSE (Mini-Mental State Examination) or MoCA (Montreal Cognitive Assessment) were calculated for the comparison of acupuncture with no acupuncture or sham acupuncture. Following 2–8 weeks of intervention with acupuncture, pooled results demonstrated significant effects of acupuncture in improving PSCI assessed by MMSE (MD [95% CI] = 2.88 [2.09, 3.66], p < 0.00001) or MoCA (MD [95% CI] = 2.66 [1.95, 3.37], p < 0.00001).

Conclusion: The results suggest that acupuncture was effective in improving PSCI and supported the needs of more rigorous design with large-scale randomized clinical trials to determine its therapeutic benefits.
Pantomime (Not Silent Gesture) in Multimodal Communication: Evidence From Children’s Narratives
Authors: Marentette Paula , Furman Reyhan , Suvanto Marcus E. , Nicoladis Elena
Published: November 2020

Pantomime has long been considered distinct from co-speech gesture. It has therefore been argued that pantomime cannot be part of gesture-speech integration. We examine pantomime as distinct from silent gesture, focusing on non-co-speech gestures that occur in the midst of children’s spoken narratives. We propose that gestures with features of pantomime are an infrequent but meaningful component of a multimodal communicative strategy. We examined spontaneous non-co-speech representational gesture production in the narratives of 30 monolingual English-speaking children between the ages of 8- and 11-years. We compared the use of co-speech and non-co-speech gestures in both autobiographical and fictional narratives and examined viewpoint and the use of non-manual articulators, as well as the length of responses and narrative quality. The use of non-co-speech gestures was associated with longer narratives of equal or higher quality than those using only co-speech gestures. Non-co-speech gestures were most likely to adopt character-viewpoint and use non-manual articulators. The present study supports a deeper understanding of the term pantomime and its multimodal use by children in the integration of speech and gesture.
Undergraduate Students’ Critical Online Reasoning—Process Mining Analysis
Authors: Schmidt Susanne , Zlatkin-Troitschanskaia Olga , Roeper Jochen , Klose Verena , Weber Maruschka , Bültmann Ann-Kathrin , Brückner Sebastian
Published: November 2020

To successfully learn using open Internet resources, students must be able tocritically search, evaluate and select online information, andverify sources.Defined as critical online reasoning (COR), this construct is operationalized on two levels in our study: (1) thestudent levelusing the newly developed Critical Online Reasoning Assessment (CORA), and (2) theonline information processing levelusing event log data, including gaze durations and fixations. The written responses of 32 students for one CORA task were scored by three independent raters. The resulting score was operationalized as “task performance,” whereas the gaze fixations and durations were defined as indicators of “process performance.” Following a person-oriented approach, we conducted a process mining (PM) analysis, as well as a latent class analysis (LCA) to test whether—following the dual-process theory—the undergraduates could be distinguished into two groups based on both their process and task performance. Using PM, the process performance of all 32 students was visualized and compared, indicating two distinct response process patterns. One group of students (11), defined as “strategic information processers,” processed online information more comprehensively, as well as more efficiently, which was also reflected in their higher task scores. In contrast, the distributions of the process performance variables for the other group (21), defined as “avoidance information processers,” indicated a poorer process performance, which was also reflected in their lower task scores. In the LCA, where two student groups were empirically distinguished by combining the process performance indicators and the task score as a joint discriminant criterion, we confirmed these two COR profiles, which were reflected in high vs. low process and task performances. The estimated parameters indicated that high-performing students were significantly more efficient at conducting strategic information processing, as reflected in their higher process performance. These findings are so far based on quantitative analyses using event log data. To enable a more differentiated analysis of students’ visual attention dynamics, more in-depth qualitative research of the identified student profiles in terms of COR will be required.
Reward Influences Masked Free-Choice Priming
Authors: Prasad Seema , Mishra Ramesh Kumar
Published: November 2020

While it is known that reward induces attentional prioritization, it is not clear what effect reward-learning has when associated with stimuli that are not fully perceived. The masked priming paradigm has been extensively used to investigate the indirect impact of brief stimuli on response behavior. Interestingly, the effect of masked primes is observed even when participants choose their responses freely. While classical theories assume this process to be automatic, recent studies have provided evidence for attentional modulations of masked priming effects. Most such studies have manipulated bottom-up or top-down modes of attentional selection, but the role of “newer” forms of attentional control such as reward-learning and selection history remains unclear. In two experiments, with number and arrow primes, we examined whether reward-mediated attentional selection modulates masked priming when responses are chosen freely. In both experiments, we observed that primes associated with high-reward lead to enhanced free-choice priming compared to primes associated with no-reward. The effect was seen on both proportion of choices and response times, and was more evident in the faster responses. In the slower responses, the effect was diminished. Our study adds to the growing literature showing the susceptibility of masked priming to factors related to attention and executive control.
On the Value of Alert Systems and Gentle Rule Enforcement in Addressing Pandemics
Authors: Roth Yefim , Plonsky Ori , Shalev Edith , Erev Ido
Published: November 2020

The COVID-19 pandemic poses a major challenge to policy makers on how to encourage compliance to social distancing and personal protection rules. This paper compares the effectiveness of two policies that aim to increase the frequency of responsible health behavior using smartphone-tracking applications. The first involves enhanced alert capabilities, which remove social externalities and protect the users from others’ reckless behavior. The second adds a rule enforcement mechanism that reduces the users’ benefit from reckless behavior. Both strategies should be effective if agents are expected-value maximizers, risk averse, and behave in accordance with cumulative prospect theory (Tversky and Kahneman, 1992) or in accordance with the Cognitive Hierarchy model (Camerer et al., 2004). A multi-player trust-game experiment was designed to compare the effectiveness of the two policies. The results reveal a substantial advantage to the enforcement application, even one with occasional misses. The enhanced-alert strategy was completely ineffective. The findings align with the small samples hypothesis, suggesting that decision makers tend to select the options that lead to the best payoff in a small sample of similar past experiences. In the current context, the tendency to rely on a small sample appears to be more consequential than other deviations from rational choice.
Can We Set Aside Previous Experience in a Familiar Causal Scenario?
Authors: Greenaway Justine K. , Livesey Evan J.
Published: November 2020

Causal and predictive learning research often employs intuitive and familiar hypothetical scenarios to facilitate learning novel relationships. The allergist task, in which participants are asked to diagnose the allergies of a fictitious patient, is one example of this. In such studies, it is common practice to ask participants to ignore their existing knowledge of the scenario and make judgments based only on the relationships presented within the experiment. Causal judgments appear to be sensitive to instructions that modify assumptions about the scenario. However, the extent to which prior knowledge continues to affect competition for associative learning, even after participants are instructed to disregard it, is unknown. To answer this, we created a cue competition design that capitalized on prevailing beliefs about the allergenic properties of various foods. High and low allergenic foods were paired with foods moderately associated with allergy to create two compounds; high + moderate and low + moderate. We expected high allergenic foods to produce greater competition for associative memory than low allergenic foods. High allergenic foods may affect learning either because they generate a strong memory of allergy or because they are more salient in the context of the task. We therefore also manipulated the consistency of the high allergenic cue-outcome relationship with prior beliefs about the nature of the allergies. A high allergenic food that is paired with an inconsistent allergenic outcome should generate more prediction error and thus more competition for learning, than one that is consistent with prior beliefs. Participants were instructed to either use or ignore their knowledge of food allergies to complete the task. We found that while participants were able to set aside their prior knowledge when making causal judgments about the foods in question, associative memory was weaker for the cues paired with highly allergenic foods than cues paired with low allergenic foods regardless of instructions. The consistency manipulation had little effect on this result, suggesting that the effects in associative memory are most likely driven by selective attention to highly allergenic cues. This has implications for theories of causal learning as well as the way causal learning tasks are designed.
Co-occurring Trajectories of Direct Aggression and Prosocial Behaviors in Childhood: Longitudinal Associations With Peer Acceptance
Authors: Ettekal Idean , Mohammadi Minoo
Published: November 2020

This study examined the longitudinal associations among children’s direct (physical and verbal) aggression, prosocial behaviors, and peer group acceptance in middle childhood (Grades 1 to 4). Children’s co-occurring aggressive and prosocial behaviors were assessed in order to identify distinct trajectory subgroups. Subsequently, variations in the development (i.e., continuity and changes) in peer acceptance were examined for each of the identified subgroups. The sample consisted of 784 children who were ethnically and socioeconomically diverse (47% girls, 37.4% Latino or Hispanic, 34.1% European American, and 23.2% African American; about 65% low SES) who were followed longitudinally from Grades 1 to 4 (Mage = 6.57 years old in Grade 1). Results revealed several distinct trajectory subgroups, including children who were primarily aggressive or prosocial, as well as children who exhibited co-occurring aggression and prosocial behaviors. Comparing these subgroups, the use of co-occurring prosocial behaviors appeared to have some protective effect on aggressive children’s peer acceptance. However, aggression was nonetheless associated with lower peer acceptance. The findings provide insights pertaining to the heterogeneity among aggressive children, the protective effects of prosocial behaviors on peer acceptance, and the differential effects of moderate versus high aggression.
Automatic Detection of Flavescence Dorée Symptoms Across White Grapevine Varieties Using Deep Learning
Authors: Boulent Justine , St-Charles Pierre-Luc , Foucher Samuel , Théau Jérome
Published: November 2020

Flavescence dorée (FD) is a grapevine disease caused by phytoplasmas and transmitted by leafhoppers that has been spreading in European vineyards despite significant efforts to control it. In this study, we aim to develop a model for the automatic detection of FD-like symptoms (which encompass other grapevine yellows symptoms). The concept is to detect likely FD-affected grapevines so that samples can be removed for FD laboratory identification, followed by uprooting if they test positive, all to be conducted quickly and without omission, thus avoiding further contamination in the fields. Developing FD-like symptoms detection models is not simple, as it requires dealing with the complexity of field conditions and FD symptoms’ expression. To address these challenges, we use deep learning, which has already been proven effective in similar contexts. More specifically, we train a Convolutional Neural Network on image patches, and convert it into a Fully Convolutional Network to perform inference. As a result, we obtain a coarse segmentation of the likely FD-affected areas while having only trained a classifier, which is less demanding in terms of annotations. We evaluate the performance of our model trained on a white grape variety, Chardonnay, across five other grape varieties with varying FD symptoms expressions. Of the two largest test datasets, the true positive rate for Chardonnay reaches 98.48% whereas for Ugni-Blanc it drops to 8.3%, underlining the need for a multi-varietal training dataset to capture the diversity of FD symptoms. To obtain more transparent results and to better understand the model’s sensitivity, we investigate its behavior using two visualization techniques, Guided Gradient-weighted Class Activation Mapping and the Uniform Manifold Approximation and Projection. Such techniques lead to a more comprehensive analysis with greater reliability, which is essential for in-field applications, and more broadly, for all applications impacting humans and the environment.
End-to-End Automated Latent Fingerprint Identification With Improved DCNN-FFT Enhancement
Authors: Deshpande Uttam U. , Malemath V. S. , Patil Shivanand M. , Chaugule Sushma V.
Published: November 2020

Automatic Latent Fingerprint Identification Systems (AFIS) are most widely used by forensic experts in law enforcement and criminal investigations. One of the critical steps used in automatic latent fingerprint matching is to automatically extract reliable minutiae from fingerprint images. Hence, minutiae extraction is considered to be a very important step in AFIS. The performance of such systems relies heavily on the quality of the input fingerprint images. Most of the state-of-the-art AFIS failed to produce good matching results due to poor ridge patterns and the presence of background noise. To ensure the robustness of fingerprint matching against low quality latent fingerprint images, it is essential to include a good fingerprint enhancement algorithm before minutiae extraction and matching. In this paper, we have proposed an end-to-end fingerprint matching system to automatically enhance, extract minutiae, and produce matching results. To achieve this, we have proposed a method to automatically enhance the poor-quality fingerprint images using the “Automated Deep Convolutional Neural Network (DCNN)” and “Fast Fourier Transform (FFT)” filters. The Deep Convolutional Neural Network (DCNN) produces a frequency enhanced map from fingerprint domain knowledge. We propose an “FFT Enhancement” algorithm to enhance and extract the ridges from the frequency enhanced map. Minutiae from the enhanced ridges are automatically extracted using a proposed “Automated Latent Minutiae Extractor (ALME)”. Based on the extracted minutiae, the fingerprints are automatically aligned, and a matching score is calculated using a proposed “Frequency Enhanced Minutiae Matcher (FEMM)” algorithm. Experiments are conducted on FVC2002, FVC2004, and NIST SD27 latent fingerprint databases. The minutiae extraction results show significant improvement in precision, recall, and F1 scores. We obtained the highest Rank-1 identification rate of 100% for FVC2002/2004 and 84.5% for NIST SD27 fingerprint databases. The matching results reveal that the proposed system outperforms state-of-the-art systems.
Future Directions and Considerations for Talent Identification in Australian Football
Authors: Bonney Nathan , Larkin Paul , Ball Kevin
Published: November 2020

As the focus on the elite Australian Football League competition becomes greater so too does the demand for success. Clubs are heavily scrutinized for their draft selections and as such are taking more interest in the younger levels of competition in an attempt to identify and monitor talent. Based on contemporary talent identification knowledge, this review examines the current talent identification process in Australian football, with a focus on areas to potentially improve or inform future developments. Currently, a significant gap exists between static and isolated assessment procedures used to identify talent in Australian football and the dynamic nature of match play. Future assessments should consider factors such as maturation, fatigue and ecological dynamics. The addition of a valid and reliable technical skill assessment (e.g., a small-sided game) to the current Australian Football League draft combine was recommended.
Application of Complex Chitosan Hydrogels Added With Canola Oil in Partial Substitution of Cocoa Butter in Dark Chocolate
Authors: Gallegos Soto Andres Silvestre , Rabelo Renata Santos , Vélez-Erazo Eliana Marcela , de Souza Silveira Paulo Túlio , Efraim Priscilla , Hubinger Miriam Dupas
Published: November 2020

The complexation of polymeric materials can be an alternative to trapping oil in a physical network for formulating foods with reduced saturated fat content. In this research, we have evaluated the use of different polymer ratios of Sodium Alginate (ALG), Carrageenan predominance iota (CR1) and Carrageenan predominance kappa (CR2) complexed with Chitosan (CHI) at a fixed polymer concentration (2% w/v) to formulate complex hydrogels and assess their oil holding capacity. The objective was to determine the polymer ratios of CHI to anionic polysaccharides (75:25, 50:50, and 25:75), determining the oil retention capacity in different ratios, and how this can affect the stability, microstructure and rheology of to produce low saturated chocolate with trapped canola oil. The stability of the hydrogels was characterized, considering the water retention and retention of canola oil in polysaccharides complexes. The more stable system was the hydrogel CHI:CR2 in a polymer ratio of 25:75. This formulation, when added of 20% of canola oil presented an apparent viscosity of 0.631 Pa.s at 300 s−1, and its use as replacer of saturated fat allowed the production of dark chocolate with 16% reduction in fat content and 80% of added cocoa butter. Stability studies showed that polysaccharides complexes network can retain the edible oil in chocolate formulation for 60 days. It has been proven that polysaccharides complexes can be incorporated to partially replace the fatty phase in chocolates without considerable changes in relevant characteristics as consumer acceptance evaluated by sensory tests and rheological properties.
Influence of Swept Blades on Low-Order Acoustic Prediction for Axial Fans
Authors: Zarri Alessandro , Christophe Julien , Moreau Stéphane , Schram Christophe
Published: November 2020

The low-speed fans used for automotive engine cooling contribute to a significant part of the global noise emitted by the vehicle. A low-order sound-prediction methodology is developed considering the blade sweep-angle effect on the acoustic predictions of the turbulence-impingement and the trailing-edge noise-generating mechanisms. We modeled these through the application of a semianalytical method based on Amiet’s airfoil theory, appropriately adapted via a strip-theory approach accounting for rotation and modified to include the blades forward curvature. Sweep was already shown in the literature to reduce the noise emitted by isolated airfoils, but its effect on rotating machines was not yet well understood. In this study, we show that the effect of the sweep-angle is to globally reduce the emitted noise by the fan and to change the sound distribution of the sources along the blade span. Thus, the sweep-angle must be considered not only because it yields a better comparison with experimental results but also because wrong conclusions on the dominating noise-generating mechanisms can be drawn when this effect is not taken into account. The investigation is finally complemented by a sensitivity analysis focusing on some of the key parameters characterizing the acoustic prediction.
A Dumbbell Shaped Piezoelectric Motor Driven by the First-Order Torsional and the First-Order Flexural Vibrations
Authors: Niu Jianye , Wu Jiang , Liu Qiming , Chen Li , Guo Shijie
Published: November 2020

A piezoelectric motor driven by the first-order torsional and first-order flexural (T/F) vibrations is designed, fabricated, and tested in this study. The actuating force is generated by the torsional vibration of the dumbbell-shaped vibrator, while the elliptical motion shape is adjusted with the flexural vibration. The rotor, pressed onto the vibrator’s lateral surface, is frictionally driven with the vibrator. Here, the torsional vibration, the shear modes of piezoelectric ceramics, and the driving method may contribute to high torque and high output power. To test the feasibility of our proposal, first, a prototype of the T/F vibrator is built and its vibration properties are explored. As predicted, the torsional and flexural vibrations are excited on the vibrator. Then, the load characteristics of the piezoelectric motor are investigated. The maximal torque, the no-load rotation speed, and maximal output power are 4.3 Nm, 125 r/min, and 16.9 W, respectively. The results imply that using the first-order torsional and the first-order flexural vibrations is a feasible method to achieve high torque and high output power of piezoelectric motors.
Sensitivity Analysis and Flight Tests Results for a Vertical Cold Launch Missile System
Authors: Głębocki Robert , Jacewicz Mariusz
Published: November 2020

In vertical cold launch the missile starts without the function of the main engine. Over the launcher, the attitude of the missile is controlled by a set of lateral thrusters. However, a quick turn might be disturbed by various uncertainties. This study discusses the problem of the influences of disturbances and the repeatability of lateral thrusters’ ignition on the pitch maneuver quality. The generic 152.4 mm projectile equipped in small, solid propellant lateral thrusters was used as a test platform. A six degree of freedom mathematical model was developed to execute the Monte-Carlo simulations of the launch phase and to prepare the flight test campaign. The parametric analysis was performed to investigate the influence of system uncertainties on quick turn repeatability. A series of ground laboratory trials was accomplished. Thirteen flight tests were completed on the missile test range. The flight parameters were measured using an onboard inertial measurement unit and a ground vision system. It was experimentally proved that the cold vertical launch maneuver could be realized properly with at least two lateral motors. It was found that the initial roll rate of the projectile and the lateral thrusters ‘igniters’ uncertainties could affect the pitch angle achieved and must be minimized to reduce the projectile dispersion.