bluuebunny/crossref_metadata_2025 huggingface dataset:
Maternal and perinatal outcomes of hypertensive disorders in pregnancy: Insights from the National Hospital of Obstetrics and Gynecology in Vietnam
Authors: Thi Huyen Anh Nguyen , Manh Thang Nguyen , Thanh Huong Truong
Published: January 2024

Introduction

Hypertension is the common disorder encountered during pregnancy, complicating 5% to 10% of all pregnancies. Hypertensive disorders in pregnancy (HDP) are also a leading cause of maternal and perinatal morbidity and mortality. The majority of feto-maternal complications due to HPD have occurred in the low- and middle-income countries. However, few studies have been done to assess the feto-maternal outcomes and the predictors of adverse perinatal outcome among women with HDP in these countries.

Methods

A prospective cohort study was conducted on women with HDP who were delivered at National Hospital of Obstetrics and Gynecology, Vietnam from March 2023 to July 2023. Socio-demographic and obstetrics characteristics, and feto-maternal outcomes were obtained by trained study staff from interviews and medical records. Statistical analysis was performed using SPSS version 26.0. Bivariate and multiple logistic regressions were done to determine factors associated with adverse perinatal outcome. A 95% confidence interval not including 1 was considered statically significant.

Results

A total of 255 women with HDP were enrolled. Regarding adverse maternal outcomes, HELLP syndrome (3.9%), placental abruption (1.6%), and eclampsia (1.2%) were three most common complications. There was no maternal death associated with HDP. The most common perinatal complication was preterm delivery developed in 160 (62.7%) of neonates. Eight stillbirths (3.1%) were recorded whereas the perinatal mortality was 6.3%. On bivariate logistic regression, variables such as residence, type of HDP, highest systolic BP, highest diastolic BP, platelet count, severity symptoms, and birth weight were found to be associated with adverse perinatal outcome. On multiple logistic regression, highest diastolic BP, severity symptoms, and birth weight were found to be independent predictors of adverse perinatal outcome.

Conclusion

Our study showed lower prevalence of stillbirth, perinatal mortality, and maternal complication compared to some previous studies. Regular antenatal care and early detection of abnormal signs during pregnancy help to devise an appropriate monitoring and treatment strategies for each women with HDP.
Dynamic modeling of African elephant populations under changing climate and habitat loss across the Greater Virunga Landscape
Authors: Nampindo Simon , Randhir Timothy O.
Published: January 2024

Elephants in Africa are declining rapidly due to habitat loss and human-wildlife conflicts, with these problems worsening with climate change. Understanding how age classes respond to such events is crucial to designing and implementing mitigation strategies and developing the adaptive capacity of wildlife managers to respond to these challenges adequately. This study builds a dynamic simulation model of the age classes of elephants and their interaction with habitat, water, and climate. The dynamic response of elephant populations to habitat change, water resources, and climate change is assessed. It is observed that climate change affects older elephants more than young ones in terms of survivability and migration. It is also likely that the undetected direct climate change impact on the elephant population is due to changes in habitats, particularly forests and wetlands used for thermal regulation. An improvement in the habitat type and availability of water resources improved the age classes of populations. The results suggest that if the environmental and anthropogenic stressors are not mitigated, Greater Virunga Landscape (GVL) will face a change in population demography for younger elephants and impact overall populations. Such age-class-specific stress could substantially affect African elephants’ long-term population viability and sustainability. Conservation of elephants requires a transboundary management approach to climate change mitigation, cooperation among conservation agencies, and effective partnerships with all relevant stakeholders for conservation.
The macroeconomic money-nature nexus: Are growing money supplies a relevant obstacle on the way to an ecologically sustainable global economy?
Authors: Möckel Stefan
Published: January 2024

Production, consumption and nature depletion have been growing rapidly for more than 300 years, even faster than exponential population growth. A comprehensive understanding of the causes behind this great acceleration is necessary if we are to achieve a sustainability transformation. This paper is intended to draw the attention in the sustainability debate to the amounts of money that have been growing rapidly all over the world. The money supply has not been a main focus so far, since for the economic mainstream it is not a growth driver, as according to the neoclassical view, money growth is largely neutralized by inflation, while for Keynesians it merely follows economic growth. However, the growing money supply means greater liquidity for consumption as well as for investments in production, assets and resource exploitation. An expansion of the money supply is even a prerequisite for a simultaneous increase in investment and consumer spending. At the same time, the expansion in the supply of raw materials, goods and services keeps inflation rates behind money growth globally. The paper aims to identify and illustrate the causalities of how the money supply and the use of natural resources are interconnected by means of economic activities. This money-nature nexus would explain why, due to high money growth rates, both the real economy and the depletion of natural resources and ecosystems continue to increase despite all efficiency improvements and sustainability efforts to date. It should therefore be a realistic fear that without a global limitation of exponential money growth, ecological sustainability cannot be achieved.
Les Mots. Diversement Rangés: Grammaire systématique du Portugais
Authors: Lawton R. A.
Published: January 2024

En se fondant sur son enseignement à l’Université de Poitiers entre 1960 et 1990, le professeur R. A. Lawton propose dans cet ouvrage une description systématique de la langue portugaise moderne et contemporaine, à partir d’un corpus d’auteurs portugais et brésiliens, essentiellement consacrée à la syntaxe, et laissant volontairement de côté certains aspects tels que la phonétique, la phonologie et la morphologie du verbe. La méthode a consisté à partir de l’observation des faits pour parvenir à une compréhension des textes observés.
Synthesis, Molecular Docking Studies and in vitro and in vivo Hypolipidemic Activity of Thiazolidinedione Derivatives
Authors: Munwar Shaik , Ilango K. , Kathiravan M.K.
Published: January 2024

This work aimed to design, synthesize novel thiazolidinedione derivatives, which were tested for their antihyperlipidemic effects. Antihyperlipidemic activity was carried through in silico docking study for the 50 thiazolidinedione derivatives (SMI-IV-1 to 50 derivatives) in comparison with standard pioglitazone against the crystal structure of protein PPARgamma (PDB ID: 6QJ5) proteins. Based on the binding energy further, best three derivatives were selected and characterized with IR, NMR and MASS studies. Then, in vitro evaluation of each derivative's antihyperlipidemic activity was carried out by observing their effects on the reduction ability of mature 3T3-L1 adipocyte cells. These cells are susceptible to cytotoxicity because of their internal accumulation of lipids. The vitality of 3T3-L1 adipocytes was identified using the MTT assay. Finally, animal experiments were conducted in order to verify the antihyperlipidemic action of the substance in Wistar rats that had been genetically modified to develop hyperlipidemia. Initially, acute toxicity study was carried out and then based on further study was investigated. Simvastatin (4 mg/kg) was used as standard drug. All the selected three derivatives showed a reversal of the rise in blood triglycerides, cholesterol and LDL from 6 to 48 h and in VLDL from 24 h. All the derivatives showed satisfactory results but derivatives SMI-IV-23 followed by SMI-IV-4 and SMI-IV-31 were given very significant results in terms of binding energy and also in vitro, in vivo experiments. Overall, the results concluded that all the thiazolidinedione derivatives were potent against hyperlipidemic condition and among the all derivatives few derivatives were showed significant role as non-toxic and in mitigation of hyperlipidemia.
Epidemiology, Characteristics, and Prognostic Factors of Primary Atypical Teratoid/Rhabdoid Tumors in the Spinal Canal: A Systematic Review
Authors: Li Zhibin , Wang Yubo , Zhao Liyan , Li Yunqian
Published: January 2024

Primary atypical teratoid/rhabdoid tumors (AT/RTs) in the spinal canal are rare central nervous system (CNS) neoplasms that are challenging to diagnose and treat. To date, there has been no standard treatment regimen for these challenging malignant tumors. Thus, we conducted this research to explore potential prognostic factors and feasible treatment modalities for improving the prognosis of these tumors. Articles were retrieved from the PubMed, MEDLINE, and Embase databases, using the keywords “atypical teratoid/rhabdoid tumor,” “rhabdoid tumor,” “spine,” “spinal,” “spinal neoplasm”, and “spinal cord neoplasm.” All eligible cases demonstrated SMARCB1-deficient expression validated by pathological examination. We collected and analyzed data related to clinical presentation, radiological features, pathological characteristics, treatment modalities and prognosis via Kaplan-Meier and Cox regression analyses. Thirty-six articles comprising 58 spinal AT/RT patients were included in the study. The median progression-free survival (PFS) and overall survival (OS) were 18 and 22 months, respectively. Kaplan-Meier analysis demonstrated significant survival improvements for OS in the nonmetastasis, male, radiotherapy and intrathecal chemotherapy groups as well as for PFS in the chemotherapy and radiotherapy groups. Multivariate analysis revealed that chemotherapy and radiotherapy were prognostic factors for improved PFS, and that intrathecal chemotherapy reduced the risk of mortality. Spinal AT/RTs are uncommon malignant entities with a dismal survival rate. Although our review is limited by variability between cases, there is some evidence revealing potential risk factors and the importance of systematic chemotherapy, intrathecal chemotherapy and radiotherapy in spinal AT/RT treatment modalities.
Multilevel Pedicle Subtraction Osteotomy for Correction of Thoracolumbar Kyphosis in Ankylosing Spondylitis: Clinical Effect and Biomechanical Evaluation
Authors: Lv Xin , Nuertai Yelidana , Wang Qiwei , Zhang Di , Hu Xumin , Liu Jiabao , Zeng Ziliang , Huang Renyuan , Huang Zhihao , Zhao Qiancheng , Li Wenpeng , Zhang Zhilei , Gao Liangbin
Published: January 2024

Objective: To compare the clinical outcomes and biomechanical characteristics of 1-, 2-, and 3-level pedicle subtraction osteotomy (PSO), and establish selection criteria based on preoperative radiographic parameters.Methods: Patients undergone PSO to treat ankylosing spondylitis from February 2009 to May 2019 in Sun Yat-sen Memorial Hospital of Sun Yat-sen University were enrolled. According to the quantity of osteotomy performed, the participants were divided into group A (1-level PSO, n = 24), group B (2-level PSO, n = 19), and group C (3-level PSO, n = 11). Clinical outcomes were assessed before surgery and at the final follow-up. Comparisons of the radiographic parameters and quality-of-life indicators were performed among and within these groups, and the selection criteria were established by regression. Finite element analysis was conducted to compare the biomechanical characteristics of the spine treated with different quantity of osteotomies under different working conditions.Results: Three-level PSO improved the sagittal parameters more significantly, but resulted in longer operative time and greater blood loss (p < 0.05). Greater stress was found in the proximal screws and proximal junction area of the vertebra in the model simulating 1-level PSO. Larger stress of screws and vertebra was observed at the distal end in the model simulating 3-level PSO.Conclusion: Multilevel PSO works better for larger deformity correction than single-level PSO by allowing greater sagittal parameter correction and obtaining a better distribution of stress in the hardware construct, although with longer operation time and greater blood loss. Three-level osteotomy is recommended for the patients with preoperative of global kyphosis > 85.95°, T1 pelvic angle > 62.3°, sagittal vertical alignment > 299.55 mm, and pelvic tilt+ chin-brow vertical angle > 109.6°.
Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis
Authors: Lembo Anthony J. , Chey William D. , Harris Lucinda A. , Frazier Rosita , Brenner Darren M. , Chang Lin , Lacy Brian E. , Edelstein Susan , Yang Yang , Zhao Suling , Rosenbaum David P.
Published: January 2024

INTRODUCTION:

This post hoc analysis evaluated the efficacy of tenapanor on abdominal symptoms in patients with irritable bowel syndrome with constipation. Abdominal symptoms assessed included pain, discomfort, bloating, cramping, and fullness.

METHODS:

The abdominal symptom data were pooled from 3 randomized controlled trials (NCT01923428, T3MPO-1 [NCT02621892], and T3MPO-2 [NCT02686138]). Weekly scores were calculated for each abdominal symptom, and the Abdominal Score (AS) was derived as the average of weekly scores for abdominal pain, discomfort, and bloating. The overall change from baseline during the 12 weeks was assessed for each symptom weekly score and the AS. The AS 6/12-week and 9/12-week response rates (AS improvement of ≥2 points for ≥6/12- or ≥9/12-week) were also evaluated. The association of weekly AS response status (reduction of ≥30%) with weekly complete spontaneous bowel movement (CSBM) status (=0 and >0) was assessed.

RESULTS:

Among 1,372 patients (684 tenapanor [50 mg twice a day] and 688 placebo), the least squares mean change from baseline in AS was −2.66 for tenapanor vs −2.09 for placebo (P < 0.0001). The 6/12-week AS response rate was 44.4% for tenapanor vs 32.4% for placebo (P < 0.0001), and for 9/12-week AS, 30.6% for tenapanor vs 20.5% for placebo (P < 0.0001). A significant association between weekly CSBM status and weekly AS response status was observed each week (P < 0.0001), with a greater proportion achieving an AS reduction in patients with >0 CSBMs in a week.

DISCUSSION:

Tenapanor significantly reduced abdominal symptoms in patients with irritable bowel syndrome with constipation, particularly pain, discomfort, and bloating measured by AS, compared with placebo.
A Cultura Corporal e a mediação do professor de Educação Física na Educação Infantil
Authors: Lupion Roberson Rodrigues , Paschoal Jaqueline Delgado
Published: January 2024

O objetivo deste estudo é discutir a relevância do professor de Educação Física para o aprendizado da criança pequena na Educação Infantil. Por meio das atividades da Cultura Corporal (jogos, brincadeiras, esportes, ginásticas, lutas etc.), esse profissional contribui para o desenvolvimento integral da criança ao priorizar as relações entre corpo, natureza e cultura, superando os conceitos biologicistas, como os discursos da aptidão física, da aprendizagem motora e do desenvolvimento motor. Como metodologia, optou-se pela pesquisa bibliográfica, tomando por base a Teoria Histórico-Cultural, a Pedagogia Histórico-Crítica e a abordagem Crítico-Superadora, fundamentando-se no materialismo histórico e dialético, em defesa do ensino e da humanização por meio do ensino planejado, sistematizado e mediado pelo professor. O intuito é buscar elementos para avançar e compreender a relação da práxis pedagógica e a aprendizagem dos conteúdos da disciplina de Educação Física para as crianças pequenas. Mediante este estudo, foi possível inferir a importância do professor especialista no ato de planejar suas ações pedagógicas, efetivando a socialização de conhecimentos científicos da referida disciplina na Educação Infantil.
Faktor-Faktor yang Mempengaruhi Brand Loyalty pada Sepatu Lokal Indonesia
Authors: Primandaru Noormalita , Kristiani Nuning , Pareallo Pian
Published: January 2024

The research conducted has the purpose to examine the effect of brand identity on consumer brand loyalty of Geoff Max footwear, the effect of brand attachment on consumer brand loyalty of Geoff Max footwear, and the influence of brand image on brand loyalty. This research is a survey research with a questionnaire in the form of a Google form as an instrument in this study. The sample in this study was Yogyakarta students who wore Geoff Max shoes, totaling 152 respondents. Data testing using SPSS. The results of the study found that brand identity had a positive but not significant effect on consumer brand loyalty Geoff Max footwear, brand attachment had a positive and significant effect on consumer brand loyalty Geoff Max footwear, and brand image had a positive and significant effect on consumer brand loyalty. Geoff Max shoes. Through this research, it is expected that it can share useful information and can provide some suggestions regarding brand identity, brand attachment, brand image, and brand loyalty from a student perspective for Geoff Max Footwear in developing his business.
Peran locus of control pada perilaku pengelolaan keuangan nelayan
Authors: Alfiani Ahmad Rizki , Iramani Rr
Published: January 2024

Perilaku pengelolaan keuangan merupakan topik riset yang perlu dikaji sampai dengan saat ini. Hal ini disebabkan karena karena banyaknya faktor yang dapat mempengaruhi perilaku seseorang dalam mengelola keuangannya. Tujuan penelitian ini adalah untuk menguji serta menganalisis locous of control, pengetahuan keuangan serta pendapatan pada perilaku pengelolaan keuangan nelayan di pulau Bawean, Jawa Timur. Penelitian ini menggunakan purposive sampling. Data penelitian ini bersumber pada data primer yang diperoleh dari responden. Penelitian ini merupakan penelitian kuantitatif dimana dalam pengumpulan datanya menggunakan metode survei. Data dikumpulkan dengan cara menyebar kuesioner baik offline maupun online melalui goole form di pulau Bawean. Teknik analisis yang digunakan adalah structural equation model. Hasil penelitian ini berhasil membuktikan bahwa locus of control dan pengetahuan keuangan mempunyai peran sangat penting dalam perilaku pengelolaan keuangan nelayan di pulau Bawean. Sementara pendapatan tidak berdampak pada pengelolaan keuangannya. Hasil ini berimplikasi dalam kehidupan nelayan di pulau Bawean untuk selalu mengendalikan diri serta meningkatkan pengetahuan keuangannya agar bijak dalam mengelola keuangannya.
Stimulation of Anxiety Management for Instagram Followers @najwashihab by Comparing the Credibility of Quraish Shihab and Najwa Shihab
Authors: Nufindra Ardin , Marta Rustono Farady , Mulyadi Fitri Sarasati , Engliana Engliana , Ahmad Rosmalia
Published: January 2024

This research explores the reactions of Instagram followers @najwashihab after watching content featuring Najwa Shihab with Quraish Shihab on Najwa Shihab's YouTube channel. This research uses a quantitative approach with survey methods. Data was obtained from survey results among followers of the Instagram account @najwashihab regarding the credibility of Quraish Shihab and Najwa Shihab in conveying messages. The results of this research show that the communicants or audience, namely Instagram followers @najwashihab, show the influence that these two sources have on the management of anxiety. Exciting findings from this research show the reactions of communicants after seeing the messages delivered by Quraish Shihab and Najwa Shihab. Instagram followers @najwashihab can manage anxiety through mindfulness, namely being aware of their surroundings and being able to accept emotions openly. Further research should consider variables such as attitude, quality of life, mental health, self-love, quarter-life crisis, and anxiety management and consider questionnaires for comprehensive research.
X Netizens' Response to the Wayan Mirna Salihin Case after the Ice Cold Documentary Film was Released in George Gerbner's Model of Mass Communication
Authors: Pradika Mohammad Fawaid
Published: January 2024

This research tries to analyze netizen Mirna Salihin's case's viral response in the mass media in 2016, and the whole public was talking about it. The case became popular again after the murder documentary was released on Netflix and sparked various discussions on social media. Netizens tried to find out what was considered odd about the murder. This research uses a qualitative descriptive method with netnographic analysis to explore social media phenomena. In this research, individuals or accounts on social media have the same capabilities as mass media. Individuals can summarize an event and choose which message (M1) will be shared with those closest to them or the public. The event summary is then spread to other individuals, triggering other opinions and being able to use the message (M1) to create other messages (M2), and so on. This research shows that the X Tirto.id account is a Man or Machine (M) who sees events and makes selections, then presents his views via social media, resulting in responses from other users such as the Bro Win and Ridwansyah Putra (E3) accounts as individuals who reinterpreted the Mirna Salihin case until other users responded again.
Surgical Outcome of Postinfarction Left Ventricular Free Wall Rupture
Authors: Na Chan-young
Published: January 2024

Background:

Left ventricular free wall rupture (LVFWR) is a rare and fatal complication after acute myocardial infarction. Early recognition and aggressive treatment are recommended.

Methods:

Between August 1999 and February 2023, 11 patients aged between 64 and 79 years developed LVFWR after acute myocardial infarction (mean interval, 3.5 days). Three patients had active bleeding (blowout-type LVFWR), and the other 8 patients experienced the oozing or sealed state. Eight patients were treated using a sutureless technique with Teflon felt and glue, 2 patients were treated using the primary suture closure technique, and 1 was treated using both the primary suture and the sutureless technique with Teflon felt and glue.

Results:

One patient died in the operating room as a result of bleeding. Cardiovascular stability and hemostasis were achieved in the other 10 patients. There were 3 early deaths (all 3 cases as a result of area bleeding; 1 was treated with primary suture, 2 with sutureless glue). Three patients received percutaneous coronary intervention before discharge. All 8 remaining patients survived and were discharged. Three patients were lost to follow-up. The follow-up period ranged from 2 to 97 months, with 4 patients exhibiting New York Heart Association class I symptoms and 1 exhibiting New York Heart Association class II symptoms.

Conclusion:

Optimal surgical treatment for postinfarction LVFWR remains controversial. The sutureless technique may be a promising strategy for treating postinfarction LVFWR.
Assessment of Multiplier Effects in the Economy of the Far Eastern Federal District: Interindustry Modeling
Authors:   Economic Research Institute FEB RAS, Belousova Anna , Isaev Artem ,   Economic Research Institute FEB RAS
Published: January 2024

For the Far Eastern constituent entities of the Russian Federation, using the Kronenberg’s Cross-Hauling Adjusted Regionalization Method (CHARM) and its subsequent hybridization, which consists of taking into account the available actual statistical data on foreign trade of the regions, regionalization of national input-output tables for 2019, 2020 was carried out. Estimates were obtained and a decrease in the values of output multipliers was identified for all Far Eastern constituent entities of the Russian Federation in 2020, generated by changes in the aggregate final demand for products of specialized industries (with the exception of the production of vehicles and equipment in the Khabarovsk Territory). The largest reductions in multipliers were recorded for the production of coke and petroleum products (Khabarovsk Territory) and fishing and fish farming (Khabarovsk and Primorsky Territories, Sakhalin Region) and were determined by a decrease in consumer demand for fuel and shifts in the structure of intermediate consumption in the fishing industry. Comparable estimates of the dynamics of multiplier effects generated by changes in the volume of final demand for products of specialized industries in the Far Eastern regions were obtained. It is shown that the maximum increase in output in 2019 and 2020 was provided by the food industry of the Primorsky Territory
Efficacy of ultrasonic cavitation in isolation of the stromal vascular fraction from adipose tissue
Authors: Wee Syeo Young , Park Jeong Do , Kang Sang Gue , Park Eun Soo
Published: January 2024

Background Adipose tissue-derived stem cells (ASCs) represent a rapidly evolving area of cell-based therapies. ASCs are harvested from the stromal vascular fraction (SVF), a heterogeneous mixture of ASCs and other cell types. Two methods are typically employed to obtain the SVF: enzymatic and mechanical. In this study, we examined the efficacy of ultrasonic cavitation in isolating the SVF from adipose tissue.Methods Human adipose tissue was procured from three patients through an aesthetic liposuction procedure. This tissue was then subjected to either an enzymatic method utilizing type II collagenase or an ultrasonic cavitation method using an Ultra Stemcell device. The cell counts and viability were determined using a cell counter. The immunophenotype of the SVF was analyzed using real-time polymerase chain reaction.Results Compared to the enzymatic method, the total cell count and cell viability of the SVF isolated through ultrasonic cavitation were relatively low. However, no significant difference was observed in the immunophenotype of CD45, CD11b, CD34, and CD105.Conclusions The ultrasonic cavitation method constitutes a clinically practical approach that offers straightforward access in the operative field. This technique is a rapid and cost-effective method for isolating the SVF.
Phenotypic Spectrum of Progressive Supranuclear Palsy: Clinical Study and Apolipoprotein E Effect
Authors: Nasri Amina , Sghaier Ikram , Neji Anis , Gharbi Alya , Abida Youssef , Mrabet Saloua , Gargouri Amina , Djebara Mouna Ben , Kacem Imen , Gouider Riadh
Published: January 2024

Objective Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder encompassing several phenotypes with various motor and cognitive deficits. We aimed to study motor and cognitive characteristics across PSP phenotypes and to assess the influence of apolipoprotein E (APOE) gene variants on PSP phenotypic expression.Methods In this 20-year cross-sectional study, we retrospectively reviewed the charts of all patients classified as PSP patients and recategorized them according to phenotype using the Movement Disorder Society criteria (2017). Phenotypes were divided into three subgroups, Richardson’s syndrome (PSP-RS), PSP-cortical (PSP with predominant frontal presentation [PSP-F] + PSP with predominant speech/language disorder [PSP-SL] + PSP with predominant corticobasal syndrome [PSP-CBS]) and PSP-subcortical (PSP with predominant parkinsonism [PSP-P] + PSP with progressive gait freezing [PSP-PGF] + PSP with predominant postural instability [PSP-PI] + PSP with predominant ocular motor dysfunction [PSP-OM] + PSP with cerebellar ataxia [PSP-C] + PSP with primary lateral sclerosis [PSP-PLS]), based on clinical presentation during the first 3 years after symptom onset, which defines the early disease stage. Clinical and neuropsychological assessment data were collected. Genotyping of APOE was performed using restriction fragment length polymorphism polymerase chain reaction and verified by Sanger sequencing.Results We included 112 PSP patients comprising 10 phenotypes classified into 48 PSP-RS, 34 PSP-cortical (PSP-CBS, 17.6%; PSP-F, 9.4%; PSP-SL, 8.2%) and 30 PSP-subcortical (PSP-P, 11.6%; PSP-PI, 8%; PSP-OM, 2.7%; PSP-PGF, 1.8%; PSP-C, 1.8%; PSP-PLS, 0.9%) subgroups. PSP-RS patients were older at disease onset (p = 0.009) and had more akinetic-rigid and levodopa-resistant parkinsonism (p = 0.006), while PSP-cortical patients had more tremors and asymmetric and/or levodopa-responsive parkinsonism (p = 0.025). Cognitive domains were significantly less altered in the PSP-subcortical subgroup. Overall, PSP-APOEε4 carriers developed parkinsonism earlier (p = 0.038), had earlier oculomotor dysfunction (p = 0.052) and had more altered cognitive profiles. The APOEε4 allele was also associated with a younger age of parkinsonism onset in the PSP-RS phenotype group (p = 0.026).Conclusion This study demonstrated the wide phenotypic spectrum of PSP among Tunisians. Disease onset and akinetic-rigid and levodopa-resistant parkinsonism were the hallmarks of the PSP-RS phenotype, while milder cognitive impairment was characteristic of the PSP-subcortical subgroup. The APOEε4 allele was associated with earlier parkinsonism and oculomotor dysfunction and seemed to play a role in defining a more altered cognitive profile in PSP patients.
The times of COVID-19 and beyond: how laboratory teaching evolved through the Pandemic
Authors: Logothetis Thomas A.
Published: January 2024

Pre–during–post lockdown waves, or how COVID-19 catalysed a change in practical chemistry instruction. This time-lined slogan reflects the University of Southampton’s response to recent imperatives in chemistry education. During the pandemic students had limited access to laboratory training. However, laboratory time has always been precious, and educators constantly have to rethink their approach to lab classes; how to best assess practical learning goals and focus students’ attention on the practical aspects during timetabled – and therefore time-limited – lab classes. The pre–during–post pandemic phases also govern the teaching split of our typical laboratory instruction, and the development during the three phases will be discussed. This article describes the evolution of the University of Southampton’s laboratory training, how resources changed, how in-laboratory student participation improved, how the pandemic influenced the scheduling of teaching activities and informed a development of our assessment strategy. It considers where the rethinking process has led to so far while acknowledging that the current laboratory course is not the end of the process but an interim position, subject to future improvements.
Better safe than sorry: dual targeting antibodies for cancer immunotherapy
Authors: Schoenfeld Katrin , Harwardt Julia , Kolmar Harald
Published: January 2024

Antibody-based therapies are revolutionizing cancer treatment and experience a steady increase from preclinical and clinical pipelines to market share. While the clinical success of monoclonal antibodies is frequently limited by low response rates, treatment resistance and various other factors, multispecific antibodies open up new prospects by addressing tumor complexity as well as immune response actuation potently improving safety and efficacy. Novel antibody approaches involve simultaneous binding of two antigens on one cell implying increased specificity and reduced tumor escape for dual tumor-associated antigen targeting and enhanced and durable cytotoxic effects for dual immune cell-related antigen targeting. This article reviews antibody and cell-based therapeutics for oncology with intrinsic dual targeting of either tumor cells or immune cells. As revealed in various preclinical studies and clinical trials, dual targeting molecules are promising candidates constituting the next generation of antibody drugs for fighting cancer.
Heat transfer characteristics of cobalt ferrite nanoparticles scattered in sodium alginate-based non-Newtonian nanofluid over a stretching/shrinking horizontal plane surface
Authors: Elattar Samia , Khan Umair , Zaib Aurang , Ishak Anuar , Alwadai Norah , Abed Ahmed M.
Published: January 2024

Magnetite and cobalt ferrite (CoFe2O4) nanoparticles are frequently utilized in several applications, including magnetic drug delivery, hyperthermia, magnetic resonance imaging, etc. In the current investigation, the magnetohydrodynamic three-dimensional heat transfer (HT) flow induced by a non-Newtonian Eyring–Powell fluid is incorporated by a carrier sodium alginate (NAC6H7O6)-based CoFe2O4 nanoparticles over a deformable (stretching/shrinking) horizontal plane surface with orthogonal shear stress and power-law velocity. The HT analysis along with the substantial effect of irregular heat source/sink as well as entropy generation is also performed. The similarity variables altered the posited leading equations into ordinary differential (similarity) equations. The function bvp4c in Matlab is then used to solve these equations numerically for various parameter values. Results indicate that, in general, there are two alternative solutions for the phenomenon of suction and deformable parameters. In addition, the essential thermal evaluation is enhanced owing to the significance of CoFe2O4 nanoparticles, magnetic parameter, and irregular heat source/sink.
Synthesis of a benzothiazole-based structure as a selective colorimetric-fluorogenic cyanate chemosensor
Authors: Kayhan Emine , Bozkurt Selahattin , Kayhan Mehmet
Published: January 2024

In this study, a new heterocyclic compound incorporating a benzothiazole moiety was specifically designed for the detection of cyanate anions, employing a hydrogen bonding mechanism. Through strategic integration of triazine and phenylenediamine cyclic groups into the compound’s structure, intramolecular hydrogen bonding interactions between the donor and acceptor sites were enhanced, leading to exceptional sensitivity towards cyanate anions. Utilizing the amino-type excited-state intramolecular proton transfer phenomenon, this new compound exhibited dual signals and achieved a significant Stokes’ shift via proton transfer, coupled with aggregation-induced emission properties. This unique combination resulted in visible color changes and an impressive fluorescence response, offering a promising solution for the sensitive detection of cyanate ions in critical environmental matrices. Cyanate detection at low concentrations by this as-synthesized compound (L1), accompanied by a distinct color change and a gradual fluorescence increase upon incremental cyanate addition demonstrated L1’s selectivity, as confirmed in the presence of various competing anions F−, Cl−, Br−, I−,

ClO

3

−

{\text{ClO}}_{3}^{-}

,

ClO

4

−

{\text{ClO}}_{4}^{-}

,

NO

3

−

{\text{NO}}_{3}^{-}

,

BrO

3

−

{\text{BrO}}_{3}^{-}

, CN− and CNO−. Spectrofluorometric investigations demonstrated that L1 shows significant potential as a selective cyanate anion detection candidate.
Gas dynamic analysis of the modern single shaft gas turbine engine flow path
Authors: Morhun Serhii , Vilkul Sergii
Published: January 2024

The paper outlines a finite volumes refined mathematical model of the working gas flow in the flow path of the three stage modern single shaft gas turbine engine that can be used in floating power plants. Such mathematical model based on the finite volumes of hexagonal-type was constructed using the three-dimensional Navier–Stokes equations for the case of viscous working fluid flow. For the problem solution such boundary conditions as “inlet’, “outlet” and “wall” have been used. The calculation is carried out in a non-stationary setting with a time step of 1.5974 × 10−6 s, which corresponds to the angle of rotation of the rotor, relative to the stator, of 0.09°. The total number of time iterations is 350. Also, it was shown that the variation field of pressure on the blades feather surfaces and the gas flow velocity due to rotation are the critical factors, causing the blades vibration. The result was confirmed with the experiment. The obtained results would be used as a base for further investigations of gas flow pressure field on the blades surface, because the gas flow pressure are key factors, causing the rotor forced vibration, and as initial data for their fatigue strength and crack study.
Aero engine health monitoring, diagnostics and prognostics for condition-based maintenance: an overview
Authors: Rath Narahari , Mishra R. K. , Kushari Abhijit
Published: January 2024

Aero engine performance deterioration highly influences its reliability, availability and life cycle. Predictive maintenance is therefore a key figure within Industry 4.0, which guarantees high availability and reduced downtime thus reduced operational costs for both military and civil engines. This leads to maintenance on demand and needs an effective engine health monitoring system. This paper overviews the work carried out on aero engine health monitoring, diagnostic and prognostic techniques based on gas path performance parameters. The inception of performance monitoring and its evolution over time, techniques used to establish a high-quality data base using engine model performance adaptation, and effects of computationally intelligent techniques on promoting the implementation of engine fault diagnosis are reviewed. Generating dependable information about the health condition of the engine is therefore a requisite for a successful implementation of condition-based maintenance. Based on this study, further research can be attempted to predict residual life of critical components using degradation pattern from aero engine performance data bank which will be an invaluable asset for engine designers as well as for operators.
Beyond the bluestones: links between distant monuments in Late Neolithic Britain and Ireland
Authors: Bradley Richard
Published: January 2024

Recent research has considered the relationship between Stonehenge and sites in south-west Wales, raising questions about whether the first monument at Stonehenge copied the form of an earlier stone circle at Waun Mawn and how the relationship between these sites was connected with the transport of bluestones between the different regions. But Stonehenge and Waun Mawn are not the only prehistoric sites in Britain and Ireland that share architectural elements and hint at social connections across vast distances of land and sea. This debate article explains how the questions raised about these Late Neolithic monuments can and should be applied to other monumental complexes to explore this insular phenomenon.
Endoscopic Sphincterotomy and Endoscopic Papillary Balloon Dilation to Do It Safely
Authors: Lee Eaum Seok
Published: January 2024

Endoscopic sphincterotomy (EST) is a basic procedure for pancreatobiliary endoscopy and is currently widely performed as a standard procedure for the treatment of various pancreatobiliary diseases worldwide. Later, in 1982, endoscopic papillary balloon dilation (EPBD) was introduced as an alternative to EST, and EPBD is known to reduce the risk of bleeding and perforation compared to EST. In order to safely and effectively perform EST and EPBD procedures, it is essential to select an appropriate target for the procedure, as well as to understand and familiarize with the anatomical structure of the duodenal papilla, related instruments, and basic techniques of EST and EPBD.
Inflation und Unternehmenssteuerung
Authors: Simon Hermann , Pedell Burkhard
Published: January 2024

Hermann Simon stammt von einem Bauernhof in der Eifel. Nach dem Studium in Köln und Bonn lehrte er 16 Jahre als Professor an den Universitäten Bielefeld und Mainz. 1985 gründete Hermann Simon mit seinem ersten Doktoranden Dr. Eckhard Kucher die Beratung Simon-Kucher. Heute ist das UnternehmenWeltmarktführer in der Preisberatung und mit 47 Büros in 30 Ländern vertreten.
Studieren mit und während der Cyberattacke
Authors: Rühmkorf Sarah
Published: January 2024

Der Beitrag befasst sich mit der Cyberattacke, die die HAW Hamburg im Dezember 2022 getroffen hat. Nach einer kurzen Einführung über Cyberangriffe im Allgemeinen werden persönliche Eindrücke und Erfahrungen sowohl aus Sicht der Studierenden als auch einer Dozentin geschildert.
Visually evoked local field potential changes in the caudate nucleus are remarkably more frequent in awake, behaving cats than in anaesthetized animals
Authors: Nyujtó Diána , Kiss Ádám , Bodosi Balázs , Eördegh Gabriella , Tót Kálmán , Kelemen András , Nagy Attila
Published: January 2024

Previous results show that halothane gas anaesthesia has a suppressive effect on the visually evoked single-cell activities in the feline caudate nucleus (CN). In this study, we asked whether the low-frequency neuronal signals, the local field potentials (LFP) are also suppressed in the CN of anaesthetized animals.

To answer this question, we compared the LFPs recorded from the CN of two halothane-anaesthetized (1.0%), paralyzed, and two awake, behaving cats during static and dynamic visual stimulation. The behaving animals were trained to perform a visual fixation task.

Our results denoted a lower proportion of significant power changes to visual stimulation in the CN of the anesthetized cats in each frequency range (from delta to beta) of the LFPs, except gamma. These differences in power changes were more obvious in static visual stimulation, but still, remarkable differences were found in dynamic stimulation, too. The largest differences were found in the alpha and beta frequency bands for static stimulation. Concerning dynamic stimulation, the differences were the biggest in the theta, alpha and beta bands.

Similar to the single-cell activities, remarkable differences were found between the visually evoked LFP changes in the CN of the anaesthetized, paralyzed and awake, behaving cats. The halothane gas anaesthesia and the immobilization suppressed the significant LFP power alterations in the CN to both static and dynamic stimulation. These results suggest the priority of the application of behaving animals even in the analysis of the visually evoked low-frequency electric signals, the LFPs recorded from the CN.
Matrimonio, divorcio y estatus social de tres mujeres en la colonia judía de Elefantina (siglo V a. C.)
Authors: Díez-Herrera Pablo-Antonio
Published: January 2024

En este trabajo vamos a estudiar la repercusión del matrimonio en el estatus social de tres mujeres de la comunidad judaíta de la isla de Elefantina durante el siglo V a. C. Veremos que a través del vínculo matrimonial se consigue la manumisión, se mantiene el estatus social, y se protege el patrimonio. Ciertamente, solo en el caso de nuestra primera protagonista sus nupcias tienen como resultado una clara promoción social. En los otros dos casos, el matrimonio sirve de protección contra el detrimento del propio estatus. Aunque, obviamente, el fin primordial de la institución matrimonial no es reforzar o mantener la posición social, el estudio de las ketuboth (contratos matrimoniales) de nuestras protagonistas nos mostrará las cláusulas que permiten el margen de maniobra para conseguir los objetivos de promoción o protección de estatus a los que se ha aludido.
Humanización
Authors: Cerón Basante Jayr Orlánder
Published: January 2024

La humanización es un eje de capital importancia en diversos ámbitos de la vida contemporánea. Su demanda surge debido a la percepción de un resquebrajamiento ontológico y la fuerza compulsiva por el tener y el poder. Se critica la impostación líquida de la modernidad al considerar que “todo (se) vale”, incluso, a riesgo de sacrificar la moral y la ética.

La humanización comienza con el reconocimiento y el valor de la dignidad del “ser-ahí”, condición inherente que hace único al individuo, quien encarna un universo axiológico y espiritual. Profundizar sobre esta perspectiva fenomenológica, exige procesos de corrección, reparación y crecimiento en lo realmente humano para hacer frente a todas las fuerzas que intentan agredir y dañar la existencia de la persona. En efecto, la conciencia de la coexistencia es su correlativo, cuya moción tiene como principio fontal la responsabilidad no solo para con el otro, sino también con lo otro.

En lo otro se sintetiza aquella dinámica acelerada y eficientista de la cultura tecnológica, sobre todo cuando la inteligencia artificial se presenta como la máxima expresión de los anhelos y deseos inmediatos de una realidad consumista y hedonista. Por eso, se destaca la necesidad de una seria y profunda reflexión bioética para iluminar el impacto de la realidad acaecido con la presencia en auge de estos artefactos inteligentes, asimismo sus implicaciones en el orden antropológico y social, entre otros.
European narratives on social media platforms: the Italian case during the Covid-19 pandemic
Authors: Miconi Andrea , Cannizzaro Sara , Risi Elisabetta
Published: January 2024

We present the findings of a quali-quantitative study of public opinion concerning Europeanization on social media platforms in Italy during the Covid-19 pandemics. The study aims to investigate which narratives about Europe are published on Italian digital platform. The research is based on a content and discourse analysis of the 720 most impactful posts published by different actors on Facebook, YouTube, and Twitter, between September and November, 2021. In order to assess the state of online discussions bearing the highest level of engagement during the pandemics, we took into account the actors responsible for the posts, the narratives surrounding the most relevant European issues (based on EuroBarometer polls), and the sentiment towards Europe.

Our quantitative results show that professionally-produced content is more dominant, and the main topics on the social media agenda are Health and Economy, in particular related to health measures and the social and economic restrictions imposed by the Italian government on citizens. Our qualitative results show that Europeanization constituted a leverage for populism in news and contents on Italian social media platforms. The positioning towards Europe is fluid and ambivalent (encompassing both positive and negative sentiment) in populist rhetoric, and Europeanization is manipulated for national purposes.