bluuebunny/crossref_metadata_2025 huggingface dataset:
Response of selected physical properties of Fluvisols to tillage implements and frequencies at Haramaya, Eastern Ethiopia
Authors: LEMMA Ararsa Boki , TSEHAİ Kibebew Kibret , WEREKA Bobe Bedadi
Published: June 2022

The study was conducted to evaluate the effects of tillage implements and frequencies on selected physical properties of Fluvisols at Haramaya University, Eastern Ethiopia, during the 2013 cropping season. Soil bulk and particle density, total porosity, texture, and soil water retention were analyzed immediately (within 72 hours) and one month after tillage for samples collected from 0-20 and 20-40 cm depths. The experiment was laid out in a split-plot design with treatment combinations consisting of three levels of tillage frequencies (0, 2 and 4) and two tillage implements, oxen-drawn traditional Maresha and disc plows, with three replications. Results indicated that the mean bulk density values were significantly different (P < 0.05) at plow layers (0-20 cm). It ranged from 1.68 g cm-3 for disc plows at two passes to 1.72 g cm-3 for zero tillage and disc plows at four passes one month after tillage at a depth of 21-40 cm. Tillage with a disc plow at increased frequencies decreased total porosity, while oxen-drawn Maresha increased total porosity. Insignificant differences (P < 0.05) in mean values of particle size distribution were observed except for percent clay content immediately after tillage with disc plows at two passes, which showed significant highest mean value (26.30%). Tillage by traditional Maresha resulted in more water holding capacity at increased tillage frequencies. Tillage practice using disc plows at two passes significantly affected the bulk density, total porosity, and soil water retention characteristics. In conclusion, tillage implements and frequencies have shown a negative effect on the physical properties of Fluvisols by disrupting the structure of the soil at surface and subsurface depths, resulting in varying levels of impact on soil bulk density, total porosity, and soil water retention characteristics. Therefore, it is recommended to use the tillage implements at reduced frequencies for less disruption of soil properties while performing soil tilth for agricultural production.
The effects of two Fe-EDDHA chelated fertilizers on dry matter production and Fe uptake of tomato seedlings and Fe forms of a calcareous soil
Authors: AY Abdurrahman , DEMİRKAYA Salih , KIZILKAYA Rıdvan , GÜLSER Coşkun
Published: June 2022

The present study was carried out to investigate the effects of two different ratios of Fe-EDDHA chelated fertilizers, (F1:4.8% and F2:6%) having the same amount of 6% soluble Fe content, on dry matter production and Fe uptake of tomato seedlings at different growth periods and Fe forms of a calcareous soil. The experiment was conducted in a factorial experimental design using Fe-EDDHA chelated fertilizers and the plant growth periods (10, 20, 30 and 40 days after seedling) with three replicates under the greenhouse conditions. The results indicated that the dry matter content, Fe uptake, chlorophyll-a, chlorophyll-b, total chlorophyll and carotenoid contents in plants generally increased over the control with increasing the growth periods. The plant dry matter contents were higher in F1 than F2 fertilization. The plant Fe uptakes in F1 treatment during the growth periods were also higher than that in F2 treatment. The carotenoid content and the chlorophyll formations in terms of both chlorophyll-a, chlorophyll-b were higher in F2 fertilization at the 20th day and higher in F1 fertilization at the 40th day. The DTPA-Fe and exchangeable-Fe contents in soil samples generally decreased while the organically bounded-Fe content in soil samples increased with increasing growth periods. It can be suggested that 4,8% of Fe-EDDHA fertilizer is more effective on Fe uptake when compared with 6% of Fe-EDDHA chelated Fe fertilizer. Therefore, F1 fertilizer can be used when chlorosis is seen on plants in calcareous soils. On the other hand, F2 fertilizer can be used if long-term Fe fertilization is desired. The differences in effectiveness between Fe-EDDHA chelated fertilizers having the same amount of water-soluble Fe content may be occurred due to differences in their chelating formulas.
Impact of forest–pasture conversion on soil physical and chemical properties
Authors: Dortzbach Denilson , Pereira Marcos Gervasio , Gonzalez Antonio Paz , Queiroz dos Santos Otavio Augusto , Piccolo Marisa de Cássia , Loss Arcângelo
Published: June 2022

The objective of this paper is to assess the changes in soil physical and chemical properties resulting from the conversion of native forest to pasture and pasture to secondary forest in the state of Santa Catarina, Brazil. Seven forest–pasture successional stages were identified using aerial photographs and satellite images acquired in 1957, 1978, and 2008. Successional stages were coded as FFF, FPF, PFF, PPF, FPP, FFP, and PPP, where the first, second, and third letters refer to the land uses (P, pasture; F, forest) practiced in 1957, 1978, and 2008, respectively. Soil samples were collected by layer at depths of 0–10, 10–20, 20–40, 40–60, 60–80, and 80–100 cm. Clay contents, soil bulk density (Db), macroporosity (MP), microporosity (mP), pH, Aluminum (Al), cation exchange capacity (CEC), calcium (Ca), potassium (K), phosphorus (P), total organic carbon (TOC) content, carbon stock, and δ13C abundance were quantified. Conversion of forest to pasture increased soil P, K, Ca, Db, and mP; and reduced MP, TOC content, and carbon stocks. The largest carbon stocks occurred in sites occupied by forests but previously used as pastures. Forest and pasture age influenced δ13C values, resulting in different isotopic signatures for different sites, confirming the transition from C3 to C4 plants. In 50-year-old pastures, about 66 % of soil TOC is still derived from the primary forest biomass.
La buena fe en las restituciones consecutivas a la nulidad de un contrato. Comentario crítico a la sentencia CSJ-SC5513 de 2021
Authors: Herrera Moreno Jorge Iván
Published: June 2022

La sentencia SC5513 de 2021 trata dos aspectos relevantes relativos a las restituciones consecutivas a la nulidad de un contrato. El primero se refiere al interrogante de hasta qué punto la buena fe en estos escenarios de nulidad contractual puede asimilarse o debe diferenciarse de la buena fe posesoria. El segundo concierne las dos tesis que ha sostenido la Corte en cuanto al momento a partir del cual el contratante de buena fe debe restituir los frutos en los escenarios de nulidad contractual. Ambos puntos ameritan un estudio crítico a partir de la jurisprudencia reciente de la Corte Suprema de justicia.
Strategic Vectors for Enterprise Development in the Context of the Digitalization of the Economy
Authors: Kibik Olha , Taran-Lala Olena , Saienko Volodymyr , Metil Tetiana , Umanets Tetiana , Maksymchuk Iryna
Published: June 2022

In the realities of the digital economy there are fast and permanent processes of digitalization of economic relations and economic activity, technologies, information and knowledge in the field of business management are becoming increasingly important. Modern economic conditions in which enterprises operate are characterized by globality, dynamism and uncertainty. One of the main factors that can ensure the company's stability in the market and help strengthen its position is a well-founded development strategy.

Depending on the direction of enterprise development, it is important to distinguish such strategies as intensification, integration and diversification, which can be applied individually or in combination. The need to adapt to the conditions of comprehensive digitalization requires enterprises to take an innovative approach to their activities, and the harmonization of the mechanism of strategic management of innovative development of the enterprise should consist of determining the vector of innovative transformations. Knowledge is very important in the innovation process, because it is not only an important contribution, but also the result of the process of transformation of innovation culture of enterprises.

The use of modern methods of e-commerce, digital platforms and blockchain allows companies to gain new benefits and opportunities. Enterprises that choose as a strategic vector of development a systematic combination of innovative approach to their activities, analysis of internal and external resources of development, adequate adaptation to the external realities of the digital economy, achieve high results in the present and future.
Psychological features of Russia’s media image
Authors: Sveshnikova Natalia , Volynskaia Maria
Published: June 2022

In the recent years in the field of theoretical and practical scientific knowledge the quality aspects of information have been highlighted as having the most influence on the audience. In that regard the most attention is being given to discourse representation; its role in social constructing is being thoroughly analysed. Studies of media discourse are conducted in terms of interdisciplinary approach. The main aim of our research is to identify psychological contents of Russia’s representation in Russian federal print mass media. We developed a 3-stage method which is a modification of content analysis method. Our research showed the possibility of psychological analysis of the discourse representation’s direction onto reflection/construction. The conducted analysis allowed us to identify structural characteristics of Russia’s media image and to describe their dynamics. We outlined the specifics of information presentation which may define the pattern of influence on the audience. The research illustrates the possibilities of conducting comparative analysis of media images of different countries.
 
Keywords: Media Image; Russia; Discourse; Psychological Influence; Representation;
Bariatric Surgery as a Complementary Treatment in Patients with Idiopathic Pseudotumor Cerebri: an Overview
Authors: Canenguez Benitez Johanna Stefany
Published: June 2022

Idiopathic Intracranial Hypertension (IIH), also known as pseudotumor cerebri, is a syndrome characterized by an increase in intracranial pressure of unknown cause, leading to headaches, frequently in the morning, progressive vision loss, papilledema, pulsatile tinnitus, and in most cases, regular cerebrospinal fluid studies. The most robust and consistent risk factors occur in female patients of reproductive age and those with obesity. This condition in recent years has increased in reported cases due to an escalation in the rate of obesity and unhealthy lifestyles. Currently, there are varying therapeutic options for primary and secondary PTC patients. The first line of therapy includes weight loss and medications such as Acetazolamide, Topiramate. Although corticosteroids have previously been used, they are not recommended due to the risk of weight gain and therefore worsening the symptoms of intracranial hypertension in these patients.
Learning From Responsiveness to a Rapidly Evolving Context: IDRC’s Covid-19 Responses for Equity Programme
Authors: Clark Louise , Carpenter Jo , Taylor Joe
Published: June 2022

This report summarises key institutional lessons that emerged from a Learning Journey commissioned by the International Development Research Centre (IDRC) for its Covid-19 Responses for Equity (CORE) programme. Learning Journeys are a research method developed by the Institute of Development Studies (IDS) to support collaborative scoping processes and provide participants with structured spaces to learn, discuss issues, and to reflect on their day-to-day work and how to apply learning. CORE was designed as a rapid response mechanism to address the sudden global shifts caused by the Covid-19 pandemic. The initiative supports 21 research projects with Southern partners across 42 countries. It seeks to understand the socioeconomic impacts of the pandemic, improve existing responses, and generate better policy options for recovery. The CORE Learning Journey was managed by the ‘Knowledge Translation’ (KT) supplier for CORE, the UK-based IDS. It brought together grantees, IDRC senior management, Regional Directors (RD), Program Officers (PO), and IDS staff, to share experiences and reflect on the successes and challenges of the CORE programme. It was framed around a central learning question: What are the key lessons to emerge from the IDRC experience of funding CORE as a responsive mechanism to provide innovative Southern-led policy and practice solutions in the context of a rapid onset and rapidly evolving global crisis?
Public Spaces, Placemaking and Integration of Migrants in Finland
Authors:   University of Jyväskylä, Lappi Tiina-Riitta , Tervonen Miika ,   Migration Institute of Finland
Published: June 2022

Placemaking and urban public spaces are important but often neglected factors in the integration and wellbeing of forcibly displaced people and other migrants. Placemaking – a multifaceted approach to the planning, design, and management of public spaces – is highly relevant for many migrants, for whom spaces outside the home are important for building community and promoting wellbeing. Yet migrants tend to have limited access and ability to use public spaces and are under-represented in urban planning processes. Efforts to integrate migrants need to explicitly address spatial aspects, and processes of urban planning and redevelopment need to be more inclusive.
Patterns of Indonesian Language Online Learning During Pandemic in Malang City
Authors: Tahmida Nova Shufia , Widyartono Didin
Published: June 2022

System changes that occur quickly and suddenly during a pandemic change learning patterns. This can be seen in the pattern of learning including planning, implementation, and assessment. This present study aimed to find out the activities of Indonesian junior high school teachers throughout the city of Malang in online learning of the Indonesian language during the pandemic, which was elaborated in the form of percentages. This present study applied quantitative-descriptive research by using a survey method. Meanwhile, the data collection was performed by using a questionnaire with data analysis in the form of a percentage description. Afterward, the results showed that online learning based on the perspective of junior high school teachers in Malang city consisted of teachers' activities at the planning step (determining of K13 guidelines and provisional curriculum in the preparation of lesson plans was 100%), action step (doing mixed learning 47.6%), and assessment step (determining the principle of assessment of special conditions by adjusting the conditions and needs of students as much as 86.7%). This study indicates that online learning in Malang Junior High School during the pandemic makes teachers find distinctive language learning patterns based on the patterns of learning.
Ecocritical Reading of Postwar Narrative: Ecocide, Trauma, and Nostalgia in Bao Ninh's Vietnam War Novel "The Sorrow of War"
Authors: Oktaviani Pranantika
Published: June 2022

The impacts of the Vietnam War are not only massive on human lives but also on nature's sustainability. The relationship between humans and nature is seen to be disrupted by the presence of armed conflict. As an anthropocentric issue, war is often seen from the perspective of humanity. This paper analyzes how the ecocritical perspective reveals the effects of war and the connection between humans and the physical environment more thoroughly. As qualitative research, the primary data was obtained based on the relevant passages in the novel and examined using the concept of Ecophobia which defines the negative relationship between humans and nature caused by a lack of consideration toward nature sustainability. This research showed how ecocritical reading of war narrative reveals the existence of ecocide as a form of landscape destruction that affects humans' lives, trauma as a result of estrangement from nature, and a sense of nostalgia resulting from the image of idyllic space in harsh postwar reality. Based on the findings, it is stated that Bao Ninh's writing on Vietnam War displays the interconnection between humans and nature, which is revealed in certain angles of conflicts.
The Power of Integrating Bite-Sized Learning and Teacher Talk on Telegram Amid Pandemic
Authors: Febrianingrum Lasmi , Rabbianty Eva Nikmatul
Published: June 2022

Bite-sized learning works in synergy with microlearning. It promotes small activities and content to understand the materials in a sequence of ways with meaningful information. Telegram, one social media, can be used as an online learning platform. Bite-sized learning encourages Telegram features in providing simple and fun activities comprehensively. Teachers shared knowledge and skills, organized teaching activities, and helped students practice through teacher talks, either in organizing a classroom or achieving the teaching goals. Since this study explored how bite-sized learning and teacher talk on Telegram in L2 Listening class, this study used a qualitative approach with a case study. The result revealed how well the teacher communicates with the students during online learning in giving instruction, sharing ideas and knowledge, stimulating students to respond to the teacher and material, cultivating students’ intellectual ability, and managing classroom activities. Furthermore, those activities need to be more noticed, extra patience and energy, a more creative in delivering instruction and materials to initiate and stimulate students to respond and engage in the class. These study results imply that during online learning, the teacher talk and bite-sized learning need to be implemented and improved well and creatively to promote students’ understanding, interaction and engagement.
Responsabilidad Social Medio Ambiental con la Arborización del Campus Universitario, Piura-Perú
Authors: ELERA OJEDA ROSARIO NELLY , Guerra Delgado Marco Sergio , Carrasco Peña Víctor Cruz , Domínguez Córdova Joel , Guerra Delgado Fernanda Belen
Published: June 2022

La Responsabilidad Social Universitaria es una política de gestión que tiene como objetivo integrar de forma transversal las distintas áreas de la universidad, dentro de los tres impactos (sociales, económicos y ecológicos) surge por la necesidad de incluir los tres estamentos de la universidad: Docentes, administrativos y estudiantes para crear conciencia en el cuidado del medio ambiente y la importancia de los árboles en nuestro ecosistema. El objetivo es mejorar las condiciones medio ambientales del campus de la Universidad Nacional de Piura y concientizar a la población universitaria sobre la preservación del medio ambiente. Estudio cuantitativo, exploratorio y transversal, midiendo el cumplimiento de las actividades programadas (fertilización, riego, deshierbe, control del crecimiento. De las 200 plantas sólo desarrollaron 180 (90%) y de los 85 participantes (estudiantes, docentes y personal administrativo), el 80% (68 participantes) cumplieron con los indicadores y objetivos planteados. La concientización colectiva medio ambiental de los docentes, estudiantes y administrativos se manifestó con la participación activa en las diferentes actividades realizadas como: siembra, protección y cuidado de árboles para mejorar el ornato y medio ambiente del campus universitario. Los participantes denotaron la mejora de la calidad de vida y el significado positivo de la siembra de árboles, proporcionando sombra y aire puro que mejoró el clima de esta calurosa ciudad norteña del Perú.
Palabras clave: Arborización; reforestación; concientización; responsabilidad ambiental; medio ambiente
Overview of the round table “Current problems of criminal law and procedure”
Authors: VOROBYEVA Svetlana V. , KOKOREV Vladimir G.
Published: June 2022

The overview of the round table “Current problems of criminal law and procedure”, organized by the De-partment of Criminal Law and Process of the Institute of Law and National Security of Derzhavin Tambov State University, is presented. The round table held within the framework of the issues discussed outlined the current topical problems of criminal law and criminal procedure, judges, lawyers, as well as teachers and students of the Institute of Law and National Security of Derzhavin Tambov State University became participants of the conference. The review highlights the content of the round table, the problematic aspects that have become the most discussed in the discussion of the speakers' topics. During the speeches, reports were heard on such problematic issues as the state and prospects of legal regulation of conducting a preliminary investigation in a criminal case; ensuring the rights and freedoms of citizens by lawyers in criminal proceedings; criteria for determining the amount of compensation for moral damage in a civil claim in criminal proceedings; features and main problems of the administration of justice in criminal cases of private charges; problems of applying the preventive measure “detention”; problems of qualification of crimes against life and health and forms and methods of struggle of law enforcement agencies in the fight against cybercrime; criminological characteristics of the activities of private military companies; problems of implementing the goals of criminal punishment; genesis of criminal responsibility for extremism under the criminal legislation of Russia and many others.
Recent progress in the data-driven discovery of novel photovoltaic materials
Authors: Lu Tian , Li Minjie , Lu Wencong , Zhang Tong-Yi
Published: June 2022

The discovery of new photovoltaic materials can facilitate technological progress in clean energy and hence benefit overall societal development. Machine learning (ML) and deep learning (DL) technologies integrated with domain knowledge are revolutionizing the traditional trial-and-error research paradigm that is associated with high costs, inefficiency, and significant human effort. This review provides an overview of the recent progress in the data-driven discovery of novel photovoltaic materials for perovskite, dye-sensitized and organic solar cells. The integral workflow of the ML/DL training progress is briefly introduced, covering data preparation, feature engineering, model building and their applications. The cutting-edge challenges and issues in the ML/DL workflow are summarized specifically for photovoltaic materials. Real examples are emphasized to illustrate how to utilize ML/DL techniques in the discovery of novel photovoltaic materials. The prospects and future directions of the data-driven discovery of novel photovoltaic materials are also provided.
MODERN TECHNOLOGIES OF HYDROGEN GENERATION AND ACCUMULATION. ANALYTIC OVERVIEW OF THEORETICAL AND PRACTICAL EXPERIENCE
Authors: Boichenko S. , Shkilniuk I. , Tselishchev О. , Matviyi І. , Tarasiuk О. , Jaworski Artur , Wos Pawel
Published: June 2022

The article discusses the competitiveness of alternative fuels and technologies in the rapidly growing segment of passenger vehicles and aviation, which globally consumes more than 70% of the fuel spent on passenger transportation and about 45% in total on transport. The emergence of new technologies in personal vehicles (electric vehicles, hydrogen cars with fuel cell, biofuels, natural gas, etc.) makes us look at the prospects for the development of this segment in a new way. On the basis of this approach, an assessment of the methods of hydrogen production was carried out. Hydrogen production by steam conversion of methane, water electrolysis and biochemical production methods were compared in this article.

             Hydrogen is not a source of energy, but it is a mean  of converting other energy sources into chemical energy in the form of accumulative pure hydrogen, which can be used subsequently during its oxigenation. In fact, a tank or other hydrogen storage device is technically similar to a battery or gas tank, and therefore it is necessary to compare not only the efficiency, but also other parameters. Hydrogen needs to be produced and converted to produce final energy, and both require energy.

             The advantages of hydrogen as a universal energy carrier are determined by environmental purity, flexibility and efficiency of energy conversion processes with its participation. Technologies of large-scale hydrogen production are quite well mastered and have an almost unlimited raw material base.

             The importance of hydrogen production technologies is determined by the high calority of hydrogen combustion and the possibility of reducing greenhouse gas emissions, since ordinary water is the combustion product.

             The article provides a comparative analysis of methods of hydrogen storage in liquid and gaseous states, carbon structures and hydride of metals
The Isotope Composition, Nature, and Main Mechanisms of Formation of Different Types and Subtypes of Salt Lakes in Transbaikalia
Authors: Borzenko S.V. , Zamana L.V. , Posokhov V.F.
Published: June 2022

—More than a hundred lakes, groundwater, rivers, and precipitation of their catchments have been studied in Transbaikalia. The chemical composition of natural waters and the mineral composition of rocks and lacustrine bottom sediments have been analyzed. The isotope composition of waters, the isotope ratios in dissolved and deposited carbonates and in bacterial mats, and the content of heavy oxygen in the aluminosilicate fraction of bottom sediments and rocks in catchments have been determined. It is shown that all secondary minerals inherit the oxygen isotope composition of water, but their oxygen is isotopically much heavier than the water oxygen, because the water–rock interaction leads to the fractionation of oxygen and the transition of its heavy isotope into secondary carbonates and aluminosilicates. Bacterial mats using oxygen of carbon dioxide ions for their vital activity are also enriched in its heavy isotope. We have established that the water of soda lakes, being less saline than other lake waters, is more enriched in heavy oxygen isotope. Mineral analysis of lacustrine bottom sediments and material from sedimentation traps revealed chemogenic carbonates and secondary aluminosilicates. The performed thermodynamic calculations confirm their possible formation in lakes. It is shown that the lake water is in equilibrium not only with carbonates, clays, and hydromica but also with zeolites, and the most alkaline and mineralized water is in equilibrium with albite. The bottom sediments of soda lakes have a greater portion of clays and carbonates than those of fresh, chloride, and sulfate waters. The enrichment of salt lake waters with heavy isotopes is due not only to evaporation but also to the water–rock interaction. The contribution of aluminosilicate hydrolysis to oxygen fractionation is confirmed by the direct dependence of the “oxygen shift” value on pH, whose value is determined by the degree of the above interaction. We have established that the diversity of the chemical and isotope compositions of lake waters is due to their multifactorial formation related to the different degrees of lake water evaporation, the different mineralization of organic matter, and the different duration of the interaction of lake waters and groundwater with rocks.
The Ambiguous "Internal Carotid Artery" - Ultrasound Diagnosis of One Case of Congenital Absence of the Internal Carotid Artery
Authors: Zhong Gang , Ning Jing , Long Xiangdang , Xie Juanjuan , Ao Kun , Liu Fang , Huang Mengyi , Zhuo Yu , Li Qiaorong , Wen Qiongli , Di Qiuyi
Published: June 2022

Background: Congenital absence of the internal carotid artery (ICA) is a very rare congenital anomaly of the ICA. Most reports in the literature are of individual cases, and most were diagnosed by computed tomographic angiography (CTA) or digital subtraction angiography (DSA). There are few reports on the diagnosis of congenital absence of the ICA by carotid Doppler ultrasound (CDUS). Case presentation: A 61-year-old male patient who was admitted to the hospital because of dizziness and showed no abnormality on CDUS conducted at another hospital. CDUS conducted at our hospital found maldevelopment of the right common carotid artery (RCCA) with normal a blood flow velocity and spectrum. A high-resistance frequency spectrum could be detected in the “ICA” that continued directly from the RCCA, and two adjacent small blood vessel branches were also observed. Superficial temporal artery tap and tracing of the courses of the small blood vessels confirmed that the RCCA directly continued to the external carotid artery (ECA). The final diagnosis was congenital absence of the ICA, which was confirmed during the clipping of an anterior communicating artery (ACoA) aneurysm.Conclusion: CDUS, as a noninvasive and rapid screening tool for cervical vascular diseases, offers a new approach for the diagnosis of congenital absence of the ICA.
Immune Checkpoint Inhibitor Induced Vitiligo in Non-Melanoma Patients: Characterization and Management
Authors: Lo Jonathan , Hanania Hannah , Keiser Monika , Patel Anisha
Published: June 2022

Immune checkpoint inhibitors (ICIs) are being used to treat a growing variety of metastatic cancers. With this increased cancer heterogeneity, there is increased patient diversity. Vitiligo is one of the earliest cutaneous adverse events (CAEs) reported with this class of medications and can have a significant psychosocial and quality of life impact on patients, in particular skin of color patients. Although ICI-associated vitiligo is a known CAE, little has been reported about the course, prognosis, and management of this disease. This single-institution, retrospective study of 151 consecutive patients with ICI-induced vitiligo was conducted using the natural language processing and the electronic medical record. Results highlight the various cancer types associated with immune checkpoint inhibitor-induced vitiligo. Our cohort had mostly melanoma patients (132, 87.4%), with the most prevalent race overall being Caucasians (108, 71.5%). Our cohort of 19 (12.6%) non-melanoma patients, however, definitively challenges the previously held notion that ICI-induced vitiligo is limited to melanoma patients. Specifically, ICI-induced vitiligo in patients with angiosarcoma, Hodgkin’s lymphoma, and mycosis fungoides were not previously reported in the literature. We noted that non-melanoma patients had a statistically significant difference (p = 0.005) in median time to onset of vitiligo compared to melanoma patients with 382 days versus 209 days, respectively. Vitiligo outcomes in our cohort showed 117 patients (78%) had stable disease, while 26 (17.3%) worsened and 7 (4.7%) improved. This supports vitiligo as a predominantly non-progressive CAE. Further, potential management options including successful repigmentation with standard of care narrowband ultraviolet light B and topical corticosteroid therapy are anecdotally demonstrated in three patients. This study emphasizes the potential impact of this disease on the growing population of patients at risk of ICI-induced vitiligo as well as the potential for effective treatment.
Application of pedicled greater omentum flap tamponade combined with laparoscopic fenestration in diaphragmatic hepatic cyst
Authors: Wu Zujian , Chen Yun , Jin Ye , Liu Changfeng , Liu Yusu , Zhang Bing
Published: June 2022

Objective To investigate the efficacy and clinical application advantage of omental tamponade with vascular pedicle combined with Laparoscopic fenestration for the treatment of diaphragmatic hepatic cyst. Methods A total of 56 patients with diaphragmatic hepatic cysts underwent laparoscopic surgery in a single tertiary academic medical center from January 2010 to October 2020, including 21 patients (non-omental group) underwent laparoscopic fenestration of liver cysts, and 36 patients underwent laparoscopic liver cyst fenestration combined with vascular pedicle omentum tamponade (omental group). The general conditions and follow-up results of the two groups were compared and annalyzed.Results The operation time of the omental group was longer than that of the non-omental group (P = 1.358E-4). There was no significant difference in postoperative complications, postoperative laboratory values, hospital stay and hospital costs (P＞0.05). In the omental group, recurrence occurred in 1 of 35 patients (4.65%) who were followeded up 12 months after surgery. In the non-omental group , of the 21 patients followed, 8 patients (38.10%) recurred 12 months after surgery, and 3 patients (14.28%) recurred 6 months after surgery.Conclusion It is an effective method to prevent the recurrence of diaphragmatic hepatic cyst after laparoscopic fenestration by packing the cyst with vascularized omentum.
Adherence to combined exercise and dietary intervention in patients with gastrointestinal cancer undergoing neo-adjuvant therapy: an open-label, pilot, randomized controlled trial.
Authors: Velho Sónia Denise Ferreira , Moço Sara , Capitão Carolina , Branco Mariana , Costa Luísa , Rodrigues Sílvia , Abreu Claudia , Pires Filipa , Sousa Pedro , Agostinho Lisa , Cruz Rita , Clemente Susana , Borges Ana , Lopes Fábio , Godinho João , Faria Ana , Teixeira José Alberto , Coelho José Luís Passos , Maio Rui , Baracos Vickie E , Cravo Marilia Lopes
Published: June 2022

BackgroundTo assess adherence of gastrointestinal cancer patients to a Combined Exercise and Dietary Intervention (CEDI) during neo-adjuvant chemotherapy.MethodsParallel randomized controlled, open label, pilot trial. A table from a web based randomization system was used to allocate treatments. 46 patients were screened at diagnosis of esophageal, gastric, pancreatic and rectal cancer from June 2018 to November 2019 at a teaching hospital in Loures, 39 were randomized. A planned interim analysis was performed and results are herein presented. Patients were randomized to receive either 8 week individualized CEDI, with moderate aerobic and resistance training, dietary counseling and oral nutritional supplements or standard care. Follow up was conducted after neo-adjuvant treatment. Main outcome measures were adherence to CEDI, change in weight, body composition and functional status. Adherence to CEDI was analyzed with an intention to treat approach, other outcome measures were analyzed with a per protocol approach. Data analysis was conducted with Chi-square test or Fisher exact test and t-test or Mann Whitney U test. Effect size was computed with Cohen’s d for t tests and r for Mann-Whitney U tests. Paired-samples t test or Wilcoxon Signed Rank Test were used to analyze longitudinal data.Results39 patients (CEDI n = 19 or control n = 20) were randomized and included in the intention to treat analysis (29 (74.3%) male, median age 63.5 (Interquartile Range (IQR):11.75)). 32 patients completed follow up. 13/19 (68.4%) were fully adherent to CEDI. CEDI patients maintained weight (Effect size (EF):0.457; 95% Confidence Interval (95%CI): [0.44,0.46]), waist circumference (EF:-0.56, 95%CI: [-1.08, -0.034]), had a lower skeletal muscle loss (EF:-0.79; [-1.77;0.18]) and improved 6 minute walking test distance (EF:-1.51; 95%CI: [-2.57;-0.44]) and quality of life function score (EF:0.45; 95%CI:[0.43,0.45]). There were 4 serious adverse events, 3 in theintervention and 1 in the control arm but none related to the intervention.ConclusionsCEDI is feasible and patients are willing to participate even under neo-adjuvant chemoradiotherapy, resulting in potential nutritional and functional benefits.Trial registrationTrial registry: www.clinicaltrials.gov; Identifier: NCT05237921, 14-2-22, retrospectively registered, https://www.clinicaltrials.gov/ct2/results?cond=&term=NCT05237921&cntry=&state=&city=&dist=
TSGA10, a new player in regulating autophagy and apoptosis
Authors: Rezazadeh Davood , Ranjbarnejad Fatemeh , Mansouri Kamran , Mostafaie Ali , Barzegari Ebrahim , Modarressi Mohammad Hossein
Published: June 2022

Testis specific gene antigen 10 (TSGA10) overexpression could inhibit angiogenesis and tumor cell proliferation, migration and invasion through inhibiting HIF-1α. The exact role of TSGA10 in autophagy and apoptosis is not clear. Present study was conducted to investigate the potential effects of TSGA10 overexpression on regulation of autophagy and apoptosis. To do so, TSGA10-containing vector (pcDNA3.1-TSGA10 vector) was designed for stable and transient transfections in HeLa cells, and clonal selection was applied. Expression of autophagy and apoptosis-related genes was assessed by real-time RT-PCR in TSGA10-overexpressing cells compared with HeLa cells transfected by empty vector. Rate of autophagy and cell viability were assessed by acridine orange and MTT assays, respectively. Our findings showed that overexpression of TSGA10 would induce autophagy under normoxic and hypoxic conditions in the presence or absence of autophagy inducers. Expression levels of autophagy and apoptosis-related genes increased significantly in TSGA10-overexpressing cells compared with control cells. In addition, HeLa cells overexpressing TSGA-10 exhibited lower expression of BCL-2 and survival rates in comparison with control cells. Molecular docking results showed that interaction between TSGA10 and BCL-2 could inhibit anti-apoptotic activity of BCL-2. According to our findings, TSGA10 overexpression has a main role in regulating autophagy and apoptosis through inhibition of BCL-2. Therefore, TSGA10 could be considered as a new regulator of autophagy and apoptosis in future studies.
AHP-Entropy-WASPAS Technique for Performance Evaluation of Agricultural Surface Water Distribution Systems Based on Water-Food-Energy Nexus
Authors: Bayat Fatemeh , Roozbahani Abbas , Shahdany Seied Mehdy Hashemy
Published: June 2022

This study aimed to quantitatively evaluate the performance of practical alternatives in modernization projects of surface water distribution systems in irrigation networks based on the water-food-energy nexus using the AHP-Entropy-WASPAS technique. Three methods of improved manual operation, decentralized automatic operation, and centralized automatic operation were developed under normal and water shortage operation scenarios and modeling the current status of water distribution in the main canal of the Isfahan Rudasht irrigation network as a case study. Water-based indicators (i.e., surface water delivery, surface water productivity, and surface water economic productivity), energy-based indicators (i.e., energy consumption, energy productivity, and economic energy productivity), and food-based indicators (i.e., food productivity and food economic productivity) were used to develop the nexus evaluation framework. The results showed that the average values of the water-food-energy nexus index in the manual operation method were estimated at 0.49 and 0.16 under normal and water shortage operation scenarios, respectively. These average values were estimated at 0.53 and 0.17 under normal and water shortage operation scenarios, respectively, by improving the method to the improved manual operation method. The decentralized automatic operation method improved these average values to 0.82 and 0.39 under normal and water shortage operation scenarios. Finally, using the centralized automatic operation method, these average values were 0.94 and 0.35 under normal and water shortage operation scenarios. Since the downstream secondary off-takes of the irrigation network receive no water even by upgrading the surface water distribution system to the decentralized automatic operation method under the water shortage operation scenario, it can be said that the performance of the centralized automatic operation method is more efficient than the decentralized automatic operation method due to the fair and uniform distribution of water in both normal and water shortage operation scenarios.
Comparing critically-ill ARDS patients with versus without COVID-19: Prospective analysis of 690 patients
Authors: Algethamy Haifa M , Aboudeif Mohammed M , Alhandi Moatz O , Majrashi Fahd Y , Hakami Shrooq H , Jan. Midhat A , Kabli Hanan A , Alhomrani Mohammed H , White Kevin P.
Published: June 2022

BACKGROUND
Few studies have directly and prospectively compared ICU patients with acute respiratory distress syndrome (1) caused by COVID-19 versus other causes, almost all previously-published studies retrospective and employing historical non-COVID cases. This study aimed to identify patient characteristics and predictors of mortality associated with COVID-related ARDS.
METHODS
We performed a Prospective cohort study. Consecutive ARDS patients with versus without confirmed COVID-19 admitted to a single ICU of a major tertiary-care hospital from March-December 2020 were included. Data were collected and both bivariate and multivariable analysis performed on COVID-19 status, demographics; morphometrics; comorbidities; presenting symptoms; admission general health status (APACHE-II); respiratory and laboratory tests at admission, within 24 hours of admission, and pre-intubation; treatments administered; and outcomes. Data capture was almost 100%.
RESULTS
Numerous clinical differences were detected between n = 160 patients with versus n = 530 patients without COVID-19. Most notably, COVID-19 patients were generally older and heavier, much more frequently presented with fevers/chills, dyspnoea, cough, anosmia/ageusia, and sore throat — and had worse outcomes, including over a two-fold rate of mortality and five-fold rate of survivors requiring prolonged supplemental oxygen. The presenting symptom dyad of fevers and/or chills and dyspnoea was 93.0% sensitive and 63.4% specific for COVID-related ARDS. A baseline APACHE-II Score ≥ 17 and requiring mechanical ventilation was 94.4% sensitive and 70.5% specific for mortality. All 37 COVID patients with an APACHE-II score > 30 died, versus survival among non-COVID patients with APACHE-II scores up to 40.
CONCLUSION
In one of the first large studies to directly compare contemporary populations of COVID-19 and non-COVID ICU patients with ARDS, employing multi-variable analysis, numerous differences in patient characteristics, presentation, and outcomes were detected.
The Clinical Characteristic and Management of patients with nocardiosis in a tertiary hospital in China
Authors: Liu Peilin , Wang Zhiqian , Jian Zijuan , Liu Xuan , Li Yanming , Yan Qun , Zhong Baiyun , Liang Xianghui , Liu Wenen
Published: June 2022

Background
Nocardiosis is an uncommon opportunistic bacterial infection caused by Nocardia spp., and its incidence has increased significantly in recent years. This study aimed to summarize the clinical characteristics and management of nocardiosis to provide a reference for clinical diagnosis and treatment.
Methods
This retrospective study was conducted based on the medical records of nocardiosis patients between January 2015 and December 2021 in a tertiary hospital in China.
Results
Overall, 44 patients with nocardiosis were included in this analysis including 26 males and 18 females with a mean age of 50.4 ± 13.2 years. Connective tissue disease (CTD) was the most common underlying disease (16/44). Twenty-six patients were given immunosuppressive therapy. The most frequent infection sites were the lungs (17/44) and skin and soft tissue (8/44). Common symptoms included cough (23/44), expectoration (18/44), fever (15/44), and subcutaneous abscesses (15/44). Average microbiology laboratory detection time was 4.8 days. Twenty-nine patients were managed only with antimicrobial treatment, and 14 patients received both antimicrobial and surgical therapies. Trimethoprim-sulfamethoxazole (TMP-SMX) was the most commonly used antibiotic (31/44). Thirty-five patients were cured or improved, 6 patients were discharged from the hospital due to poor prognosis, and 1 patient died.
Conclusion
Clinicians should be alert to immunocompromised patients, especially those with CTD, and tend to pulmonary or cutaneous infections. Smear microscopic examination and prolonged culture time may aid Nocardia identification. Patients with nocardiosis can be treated with antimicrobials or surgical therapy. TMP-SMX remains the mainstay treatment, and its early and prompt use may improve nocardiosis outcome.
Friction and Pore-Fluid Pressure Conditions in Faults Controlling Earthquake Rupture Dynamics
Authors: Tsuda Kenichi , Hirono Tetsuro
Published: June 2022

Although direct recovery of frictional features of fault rocks through drilling projects and multiple experimental analyses such as the Japan Trench Fast Drilling Project (JFAST) and the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) been recently performed, the conditions of rupture propagation to levels of friction and pore-fluid pressure remains uncertain. In order to try to invest such issues, we performed dynamic rupture simulations based on experimental friction datasets measured in fault rocks on the Nankai Trough that was ruptured during the 1944 Mw8.0 Tonankai earthquake. A steady-state friction triggered large slip (about 30 m) near the trench, whereas a high friction suppressed the rupture. The environmental condition in which the pore-fluid pressure was nearly equal to the lithostatic stress decreased the slip about 25 m in case of low friction. However, in case of high friction with negative stress drop, the slip reached about 20 m because the low shear strength did not arrest the inertial motion of rupture propagation. Such differences in fault-rock properties and fluid conditions may fundamentally influence on the complexity and the variability of rupture propagation
METTL3 affects FLT3-ITD+ Acute Myeloid Leukemia by mediating autophagy by regulating PSMA3-AS1 stability
Authors: Wu Shenghao , Weng Shanshan , Zhou Wenjin , Chen Yuemiao , Liu Zhen
Published: June 2022

Objective
The study was designed to explore the role of PSMA3-AS1 in initiation and progression of acute myeloid leukemia (AML) and investigate its action mechanism.
Methods
Expression of PSMA3-AS1, miR-20a-5p and ATG16L1 both in vitro and in vivo was measured by qRT-PCR. The expression of protein was detected by western blot assay. Edu staining and flow cytometry were utilized to measure cell proliferation and apoptosis. Potential target was predicted by bioinformatics and was verified by dual-luciferase report gene assay and RNA pull down assay. QRT-PCR was used to quantify autophagy (LC3, Beclin1, P62) related genes. The m6A modification test is used to verify the effect of METTL3 on PSMA3-AS1. Tumor model was used to identify the effect of PSMA3-AS1 on tumor growth in vivo, and immunohistochemistry was applied to detect expression of ki67 and TUNEL.
Results
The results indicate that PSMA3-AS1 was upregulated in FLT3-ITD + AML patients. Si-PSMA3-AS1 can inhibit the proliferation, autophagy and inhibit the apotosis in MV4-11 cells. METTL3 could enhances the PSMA3-AS1 RNA stability. In addition, this study revealed that PSMA3-AS1 affected FLT3-ITD + AML by targeting expression of miR-20a-5p, and miR-20a-5p further modulated expression of ATG16L1, an mRNA that down-regulated in AML, to affect disease advancement.
Conclusion
PSMA3-AS1 could promote FLT3-ITD + AML progression by regulating the level of autophagy through the miR-20a-5p/ATG16L1 pathway. In addition, the increase of PSMA3-AS1 may be caused by the involvement of METTL3 in regulating its stability. This discovery will provide new horizons for early screening and targeted therapy of FLT3-ITD + AML.
Two Stages Active Disturbance Rejection Control for Coupled Permanent Magnet Synchronous Motors System with Mismatch Disturbance
Authors: Pu Chunmei , Wang Zhanshan , Wang Suran
Published: June 2022

Aiming at the disturbance mismatch in the coupled permanent magnet synchronous motors(CPMSMs) system, a new design method of active disturbance rejection controller(ADRC) is proposed in this paper. In order to eliminate the coupling tension between motors, the control law is designed in two stages, so that the disturbance and control input appear in the same channel, and then the ADRC is designed to realize the control goal by using the control input. The proposed method is more universal than the previous methods, and the parameter tuning is easier. At the same time, it simplifies the design steps of the controller and reduces the requirements of the control system.