bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbial Fermentation and Its Role in Quality Improvement of Fermented Foods
Authors: Sharma Ranjana , Garg Prakrati , Kumar Pradeep , Bhatia Shashi Kant , Kulshrestha Saurabh
Published: November 2020

Fermentation processes in foods often lead to changes in nutritional and biochemical quality relative to the starting ingredients. Fermented foods comprise very complex ecosystems consisting of enzymes from raw ingredients that interact with the fermenting microorganisms’ metabolic activities. Fermenting microorganisms provide a unique approach towards food stability via physical and biochemical changes in fermented foods. These fermented foods can benefit consumers compared to simple foods in terms of antioxidants, production of peptides, organoleptic and probiotic properties, and antimicrobial activity. It also helps in the levels of anti-nutrients and toxins level. The quality and quantity of microbial communities in fermented foods vary based on the manufacturing process and storage conditions/durability. This review contributes to current research on biochemical changes during the fermentation of foods. The focus will be on the changes in the biochemical compounds that determine the characteristics of final fermented food products from original food resources.
Grape Pomace Valorization: A Systematic Review and Meta-Analysis
Authors: Antonić Bojan , Jančíková Simona , Dordević Dani , Tremlová Bohuslava
Published: November 2020

This systematic review aimed to collect data and analyze the possible use of grape pomace, a winemaking industry byproduct, in the production of fortified foods. The English articles found in Web of Science, Scopus, and Google Scholar, from January 2006 until May 2020, were used for the conduction of overview tables and meta-analysis. The systematic review emphasized the two main issues concerning grape pomace application to other food products: (i) grape pomace contains high amounts of health promoting compounds; and (ii) the use of grape pomace is influencing the waste management. The grape pomace has been used in the fortification of plant origin food, meat, fish, and dairy products, mainly due to higher polyphenols and dietary fiber contents. The fortification was declared as successful in all studied food types. The change of color, caused by polyphenolic compounds, was mainly observed as an adverse effect of the fortification. Higher levels of fortification also caused notable undesirable changes in texture. The most valuable influence of the grape pomace addition according to included papers and meta-analysis is certainly a higher nutritional quality and oxidative stability of fortified products, reflected as higher polyphenol and total dietary fiber content.
Are the Italian Children Exposed to Advertisements of Nutritionally Appropriate Foods?
Authors: Nucci Daniele , Rabica Filippo , Dallagiacoma Giulia , Fatigoni Cristina , Gianfredi Vincenza
Published: November 2020

Unhealthy eating habits are one of the main risk factors for overweight/obesity, and food marketing plays a major role in their development. The aim of this study was to monitor the amount and the characteristics of food marketing directed to Italian children broadcasted on television (TV). The WHO tool to assess food and beverage multimedia marketing aimed at children was used to analyze TV recordings. Type of product branded, viewing time, channel’s target, and broadcasting company were the exposure variables analyzed. The power of persuasive techniques was also assessed. Food products were categorized as either core or non-core products on the basis of their nutritional profile. A total of 320 h of TV broadcasting was analyzed, including 51.7 h of commercials. Food and beverages were the second most frequently advertised products, with an average of 6 food advertisements per hour during peak viewing time. A total of 23.8% of food advertisements were recorded during the time slot of 3:00 p.m. Considering food and beverage commercials, “humor” was the most frequently used primary persuasive technique, while the “image of the product/packaging” was the most commonly used secondary persuasive technique. Products specifically targeted to children were 94.3% non-core. Our findings indicate that core foods are highly underrepresented in TV commercials, especially during children TV programs and peak viewing time.
Determinants for Safety Climate Evaluation of Construction Industry Sites in Saudi Arabia
Authors: Makki Anas A. , Mosly Ibrahim
Published: November 2020

The hazardous nature of the construction industry requires giving increasing attention to safety management and the available means to eliminate or reduce the risks of workers’ injuries. Workers in the construction industry of Saudi Arabia face similar daily risks as workers face in other countries. The safety climate significantly influences safety performance, making research in the field of safety climate a vital step toward raising safety levels at construction sites. This study aims at exploring key components of determinants for safety climate evaluation of Saudi Arabian construction sites. Using data collected from 401 industry practitioners, a dimension reduction statistical approach and exploratory factor/principal component analysis were conducted on 13 safety climate factors that were found to significantly correlate with safety climate evaluation of construction sites. The study revealed three key components of determinants for safety climate evaluation of Saudi Arabian construction sites. Notable components are safety commitment, safety interaction, and safety support. Implications of this study include assisting construction industry stakeholders to bolster the safety climate at their construction sites, which should lead to improved safety performance levels.
Information in Spanish on the Internet about the Prevention of COVID-19
Authors: Hernández-García Ignacio , Giménez-Júlvez Teresa
Published: November 2020

Objective. Our objective was to analyze the evolution of the information in Spanish online about the prevention of the coronavirus disease 2019 (COVID-19). Methods. On 1 March and 13 July 2020, two searches were conducted on Google with the terms “Prevencion COVID-19” and “Prevencion Coronavirus”. In each stage, a univariate analysis was performed to study the association of the authorship and country of origin with the basic recommendations to avoid COVID-19 provided by the World Health Organization (WHO). Results. A total of 120 weblinks were evaluated. The recommendation found most frequently in both stages was “wash your hands frequently” (93.3% in March vs. 90.0% in July). There was a significant increase in the detection of the following recommendations: “avoid touching your face” (56.7% vs. 80.0%) and “stay at home if you feel unwell” (28.3% vs. 63.3%). Weblinks of official public health organizations more frequently provided the advice to “seek medical advice if you develop a fever/cough or have difficulty breathing”. Furthermore, in July, such weblinks provided recommendations to “avoid touching your face” and “maintain a distance of one meter” more frequently than the mass media (OR = 11.5 and 10.5, respectively). In March, the recommendation to “maintain a distance of at least 1 m” was associated with the weblinks from countries with local transmission/imported cases (OR = 8.1). Different/ambiguous information regarding the WHO recommendations was detected in four weblinks. Conclusion. The availability of information in Spanish online on basic prevention measures has improved over time, although there is still room for improvement. It is necessary to promote the use of the websites of official public health organizations among Spanish-speaking users.
Internet Addiction among Young Adult University Students: The Complex Interplay between Family Functioning, Impulsivity, Depression, and Anxiety
Authors: Marzilli Eleonora , Cerniglia Luca , Ballarotto Giulia , Cimino Silvia
Published: November 2020

International research has underlined that both interpersonal, self-regulation, and comorbid variables can lead to a higher risk of developing internet addiction (IA) among young adults. To date, no studies have explored the interplay between young adults’ family functioning, impulsivity, and psychopathological difficulties. In a community sample of 244 young adult university students, this study aims to assess the relationship between young adults’ IA and young adults’ gender, the perception of their family functioning, impulsivity level, and depressive and anxiety symptoms, considering the possible interplay between these variables. The presence and the severity of IA were addressed through the Internet Addiction Test (IAT). Moreover, young adults filled out self-reporting questionnaires, assessing their perception of family functioning and their impulsivity levels and psychopathological symptoms. Results showed no significant association between the youth’s gender and IA. However, moderately addicted young adults were more likely to report poorer quality of family affective involvement and higher attentional impulsivity and depressive problems than other groups. Moreover, young adults’ attentional impulsivity mediated the relationship between family affective involvement and IA. This study provides new evidence on the complex interaction between individuals and interpersonal risk factors involved in IA among young adults, with important implications for the planning of intervention treatments.
A Social Network Analysis of Tweets Related to Masks during the COVID-19 Pandemic
Authors: Ahmed Wasim , Vidal-Alaball Josep , Lopez Segui Francesc , Moreno-Sánchez Pedro A.
Published: November 2020

Background: High compliance in wearing a mask is a crucial factor for stopping the transmission of COVID-19. Since the beginning of the pandemic, social media has been a key communication channel for citizens. This study focused on analyzing content from Twitter related to masks during the COVID-19 pandemic. Methods: Twitter data were collected using the keyword “mask” from 27 June 2020 to 4 July 2020. The total number of tweets gathered were n = 452,430. A systematic random sample of 1% (n = 4525) of tweets was analyzed using social network analysis. NodeXL (Social Media Research Foundation, California, CA, USA) was used to identify users ranked influential by betweenness centrality and was used to identify key hashtags and content. Results: The overall shape of the network resembled a community network because there was a range of users conversing amongst each other in different clusters. It was found that a range of accounts were influential and/or mentioned within the network. These ranged from ordinary citizens, politicians, and popular culture figures. The most common theme and popular hashtags to emerge from the data encouraged the public to wear masks. Conclusion: Towards the end of June 2020, Twitter was utilized by the public to encourage others to wear masks and discussions around masks included a wide range of users.
Does Environmental Regulation Affect Export Quality? Theory and Evidence from China
Authors: Xie Jing , Sun Qi , Wang Shaohong , Li Xiaoping , Fan Fei
Published: November 2020

Most studies focus on the empirical investigation of the relationship between environment and trade, but they lack a systematic theoretical framework. To fill this gap, this study constructs an analytical framework of export competitiveness from the perspective of product quality, and reveals the theoretical mechanism of environmental regulation affecting export quality. We empirically examine the impact of environmental regulation on the export quality of China’s manufacturing industry, as well as its possible mechanism. Our findings show that environmental regulation can significantly promote the export quality upgrading of the manufacturing industry and that process and product productivity are two possible channels through which such regulation affects export quality, although their mediating effects are in opposite directions. The mediating effect of product productivity is greater than that of process productivity, indicating that environmental regulation mainly has an innovation offset effect on China’s manufacturing industry. For pollution-intensive industries, environmental regulation plays a significant promoting role through the channel of product productivity, but, for clean industries, environmental regulation has an inhibitory effect through the channel of process productivity. These findings provide important enlightenment for the coordinated development of China’s ecological civilization and trade power.
Using Mobile Applications to Increase Physical Activity: A Systematic Review
Authors: Pradal-Cano Laura , Lozano-Ruiz Carolina , Pereyra-Rodríguez José Juan , Saigí-Rubió Francesc , Bach-Faig Anna , Esquius Laura , Medina F. Xavier , Aguilar-Martínez Alicia
Published: November 2020

Unhealthy diet and physical inactivity—major risk factors for the main non-communicable diseases—can be addressed by mobile health applications. Using an evidence-based systematic review design, we analysed studies on mobile applications to foster physical activity to determine whether they met the objective of increasing adults’ physical activity. A bibliographic search was conducted in October 2020 using PubMed, Cochrane Library Plus, Biomed Central, Psychology Database, and SpringerLink, retrieving 191 articles. After titles and abstracts were reviewed, 149 articles were excluded, leaving 42 articles for a full-text review, of which 14 met the inclusion criteria. Despite differences in study duration, design, and variables, 13 of the 14 studies reported that applications were effective in increasing physical activity and healthy habits as dietary behaviour. However, further longer-term studies with larger samples are needed to confirm the effectiveness of mobile health applications in increasing physical activity.
Unmet Healthcare Needs of Children in Vulnerable Families in South Korea: Finding from the Community Child Center Child Panel Survey
Authors: Baek Suyon , Choi Eun-Hi , Lee Jungeun
Published: November 2020

Presented in this paper is a study that examined the status of unmet healthcare needs of children in vulnerable families and identified factors affecting such unmet needs. The Community Child Center (CCC) Child Panel Survey data in Korea were used. A multiple stepwise logistic regression analysis was performed to examine factors influencing unmet healthcare needs of children. Influencing factors comprised predisposing, enabling, and need factors based on the Andersen Behavioral Model of Health Services Utilization. A total of 340 sixth-graders from vulnerable families participated, and 96 (28.2%) children had unmet healthcare needs. Factors included absence of an after-school caregiver (OR = 1.95, 95% CI [1.16, 3.27]), perceived physical symptoms (OR = 1.33, 95% CI [1.02, 1.73]), parental indifference (OR = 1.33, 95% CI [1.002, 1.77]), duration of daily stay at CCCs (OR = 1.32, 95% CI [1.01, 1.71]), and satisfaction with CCC teachers (OR = 0.65, 95% CI [0.49, 0.85]). The relationship with parents and CCC teachers had the strongest influence on unmet healthcare needs of children. In order to reduce the unmet healthcare needs of children in vulnerable families, existing support structures should be expanded to offer financial and administrative support for children’s parents and CCC teachers.
Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
Authors: Melzer Catharina , Ohe Juliane von der , Hass Ralf
Published: November 2020

While cell fusion demonstrates an important pathway during tissue development and regeneration of distinct organs, this process can also contribute to pathophysiological phenotypes during tumor progression. Hybrid cell formation after heterofusion between cancer cells and various other cell types within the tumor microenvironment is observed in vitro and in vivo. In particular, mesenchymal stroma/stem-like cells (MSC) perform diverse levels of communication with cancer cells by exhibiting anti- and pro-tumorigenic effects. During these cellular interactions, MSC can eventually fuse with cancer cells. Thereby, the newly generated disparate hybrid populations display aneuploidy associated with chromosomal instability. Based upon a subsequent post-hybrid selection process (PHSP), fused cancer cells can undergo apoptosis/necroptosis, senescence, dormancy, or a proliferative state by acquisition of new properties. Consequently, PHSP-surviving hybrid cancer cells demonstrate altered functionalities within the tumor tissue. This is accompanied by changes in therapeutic responsiveness and a different metastatic behavior. Accordingly, enhanced tumor plasticity interferes with successful therapeutic interventions and aggravates patient prognoses. The present review article focusses on fusion of MSC with different human cancer cells, in particular breast cancer populations and resulting characteristics of various cancer hybrid cells. Moreover, some mechanisms of cancer cell fusion are discussed together with multiple PHSP pathways.
Molecular Characterization of Temozolomide-Treated and Non Temozolomide-Treated Glioblastoma Cells Released Extracellular Vesicles and Their Role in the Macrophage Response
Authors: Panzarini Elisa , Tacconi Stefano , Carata Elisabetta , Mariano Stefania , Tata Ada Maria , Dini Luciana
Published: November 2020

Extracellular vesicles (EVs) are widely investigated in glioblastoma multiforme (GBM) for their involvement in regulating GBM pathobiology as well as for their use as potential biomarkers. EVs, through cell-to-cell communication, can deliver proteins, nucleic acids, and lipids that are able to reprogram tumor-associated macrophages (TAMs). This research is aimed to concentrate, characterize, and identify molecular markers of EVs subtypes released by temozolomide (TMZ)-treated and non TMZ-treated four diverse GBM cells. Morphology, size distribution, and quantity of small (sEVs) and large (lEVs) vesicles were analyzed by cryo-TEM. Quality and quantity of EVs surface markers were evaluated, having been obtained by Western blotting. GBM cells shed a large amount of EVs, showing a cell line dependent molecular profile A comparative analysis distinguished sEVs and lEVs released by temozolomide (TMZ)-treated and non TMZ-treated GBM cells on the basis of quantity, size and markers expression. Finally, the GBM-derived sEVs and lEVs, irrespective of TMZ treatment, when challenged with macrophages, modulated cell activation toward a tendentially M2b-like phenotype.
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity
Authors: Wang Joy X. , Choi Stephen Y.C. , Niu Xiaojia , Kang Ning , Xue Hui , Killam James , Wang Yuzhuo
Published: November 2020

Immune evasion and altered metabolism, where glucose utilization is diverted to increased lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has long been considered a waste product of this alteration, it is now well accepted that increased lactic acid production and the resultant acidification of the tumor microenvironment (TME) promotes multiple critical oncogenic processes including angiogenesis, tissue invasion/metastasis, and drug resistance. We and others have hypothesized that excess lactic acid in the TME is responsible for suppressing anticancer immunity. Recent studies support this hypothesis and provide mechanistic evidence explaining how lactic acid and the acidic TME impede immune cell functions. In this review, we consider lactic acid’s role as a critical immunoregulatory molecule involved in suppressing immune effector cell proliferation and inducing immune cell de-differentiation. This results in the inhibition of antitumor immune responses and the activation of potent, negative regulators of innate and adaptive immune cells. We also consider the role of an acidic TME in suppressing anticancer immunity. Finally, we provide insights to help translate this new knowledge into impactful anticancer immune therapies.
Enhanced Radiosensitization for Cancer Treatment with Gold Nanoparticles through Sonoporation
Authors: Lu Shao-Lun , Liu Wei-Wen , Cheng Jason Chia-Hsien , Lin Lien-Chieh , Wang Churng-Ren Chris , Li Pai-Chi
Published: November 2020

We demonstrate the megavoltage (MV) radiosensitization of a human liver cancer line by combining gold-nanoparticle-encapsulated microbubbles (AuMBs) with ultrasound. Microbubbles-mediated sonoporation was administered for 5 min, at 2 h prior to applying radiotherapy. The intracellular concentration of gold nanoparticles (AuNPs) increased with the inertial cavitation of AuMBs in a dose-dependent manner. A higher inertial cavitation dose was also associated with more DNA damage, higher levels of apoptosis markers, and inferior cell surviving fractions after MV X-ray irradiation. The dose-modifying ratio in a clonogenic assay was 1.56 ± 0.45 for a 10% surviving fraction. In a xenograft mouse model, combining vascular endothelial growth factor receptor 2 (VEGFR2)-targeted AuMBs with sonoporation significantly delayed tumor regrowth. A strategy involving the spatially and temporally controlled release of AuNPs followed by clinically utilized MV irradiation shows promising results that make it worthy of further translational investigations.
Supplemental 25-hydroxycholecalciferol Alleviates Inflammation and Cardiac Fibrosis in Hens
Authors: Chou Pao-Chia , Chen Yu-Hui , Chung Thau-Kiong , Walzem Rosemary L. , Lai Lih-Shiuh , Chen Shuen-Ei
Published: November 2020

Broiler breeder hens with efficient feed conversion rate under restricted feed intake (R-hens) or allowed unlimited access to feed (Ad-hens) progressed with cardiac functional failure and suffered early sudden death. A supplement of 69 μg 25-hydroxycholecalciferol (25-OH-D3)/kg feed improved heart health and rescued livability in both R- and Ad-hens throughout laying stage (26–60 wks). Improvements occurred through cardiac hypertrophic remodeling, reduced arrhythmias, and pathological cues. Here, we further demonstrated consistently decreased circulating and cardiac IL-6 and IL-1β levels in conjunction with reduced cardiac chemoattraction and leukocyte infiltration by 25-OH-D3 in Ad-hens and in R-hens at later time points (35 and 47 wks) (p < 0.05). Supplemental 25-OH-D3 also ameliorated cardiac fibrosis, endoplasmic reticulum (ER) stress, and autophagy, mostly in Ad-hens, as both collagen content and expression of COL3A1, as well as CCAAT box binding enhancer homologous protein (CHOP) and activating transcription factor 6 (ATF6), were consistently decreased, and suppression of microtubule-associated protein 1 light Chain 3 beta (LC3B) and Sequestosome 1 (SQSTM1) was rescued at 35 and 47 wks (p < 0.05). Vitamin D receptor-NF-κB signaling was shown to mediate these beneficial effects. The present results demonstrate that ER stress and autophagic processes along the sequence from inflammation to fibrotic changes contribute to pathological cardiac remodeling and functional compromise by Ad-feed intake. 25-OH-D3 is an effective anti-inflammatory and anti-fibrotic supplement to ameliorate cardiac pathogenesis in broiler breeder hens.
Climate Emergency Adaptation and Sustainable Management Strategies in Rural and Agricultural Landscapes
Authors: Nikologianni Anastasia , Moore Kathryn , Larkham Peter J.
Published: November 2020

This paper discusses the way in which climate emergency-related strategies and the concepts of climate adaptation, sustainability and governance are being introduced into rural and agricultural landscapes. To investigate environmental impacts on climate change, it uses examples from the ‘Landscape Observatory’ (Catalonia) and the ‘Room for the River’ (the Netherlands) landscape programmes. Noordwaard is the largest rural project of the Room for the River programme, dealing with agricultural land, farming and nature reserves at a strategic scale. It demonstrates the potential and significance of addressing the sea rising water levels by creating landscape climate adaptation projects by introducing the ideas of landscape, low carbon, ecosystem services and governance as vital aspects of rural infrastructure, which underpin the ways in which agricultural land and water are managed. The Landscape Observatory has had a significant impact on the development of landscape policies in Catalonia and has been influential in a global level. Focusing on Lluçanès and the establishment of a Landscape Charter protecting the agricultural land and examining the natural area of La Cerdanya in Pyrenees, the research extracts best practices in policy and legislation as well as participatory methods on climate and landscape awareness. This research concludes that a communication strategy strongly supported by policies, legislation and governance structures, in conjunction with a wider understanding of the role of landscape, results in significantly improved responses to deal with the challenges of the climate crisis in rural and agricultural areas.
Gene Characterization and Enzymatic Activities Related to Trehalose Metabolism of In Vitro Reared Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) under Sustained Cold Stress
Authors: Lü Xin , Han Shi-chou , Li Zhi-gang , Li Li-ying , Li Jun
Published: November 2020

Trichogramma spp. is an important egg parasitoid wasp for biocontrol of agriculture and forestry insect pests. Trehalose serves as an energy source or stress protectant for insects. To study the potential role of trehalose in cold resistance on an egg parasitoid, cDNA for trehalose-6-phosphate synthase (TPS) and soluble trehalase (TRE) from Trichogramma dendrolimi were cloned and characterized. Gene expressions and enzyme activities of TdTPS and TdTRE were determined in larvae, prepupae, pupae, and adults at sustained low temperatures, 13 °C and 16 °C. TdTPS and TdTRE expressions had similar patterns with higher levels in prepupae at 13 °C and 16 °C. TdTPS enzyme activities increased with a decrease of temperature, and TdTRE activity in prepupae decreased sharply at these two low temperatures. In vitro reared T. dendrolimi could complete entire development above 13 °C, and the development period was prolonged without cold injury. Results indicated trehalose might regulate growth and the metabolic process of cold tolerance. Moreover, 13 °C is the cold tolerance threshold temperature and the prepupal stage is a critical developmental period for in vitro reared T. dendrolimi. These findings identify a low cost, prolonged development rearing method, and the cold tolerance for T. dendrolimi, which will facilitate improved mass rearing methods for biocontrol.
First Evidence of Bud Feeding-Induced RNAi in a Crop Pest via Exogenous Application of dsRNA
Authors: Willow Jonathan , Soonvald Liina , Sulg Silva , Kaasik Riina , Silva Ana Isabel , Taning Clauvis Nji Tizi , Christiaens Olivier , Smagghe Guy , Veromann Eve
Published: November 2020

Spray-induced gene silencing (SIGS) is a potential strategy for agricultural pest management, whereby nucleotide sequence-specific double-stranded RNA (dsRNA) can be sprayed onto a crop; the desired effect being a consumption of dsRNA by the target pest, and subsequent gene silencing-induced mortality. Nucleotide sequence-specificity is the basis for dsRNA’s perceived biosafety. A biosafe approach to pollen beetle (Brassicogethes aeneus) management in oilseed rape (Brassica napus) agroecosystems is needed. We examined the potential for SIGS in B. aeneus, via bud feeding, a field-relevant dsRNA exposure route. Oilseed rape buds were uniformly treated with dsRNA designed to target αCOP in B. aeneus. Our model control dsRNA (dsGFP) remained detectable on buds throughout the entire 3 d exposure period. When applied at 5 µg/µL, dsαCOP induced significant αCOP silencing 3 d after dietary exposure to buds treated with this dsαCOP concentration. We also observed a trend of increased αCOP silencing with increasing concentrations of dsαCOP at both 3 and 6 d. Furthermore, we observed a marginally significant and significant reduction in B. aeneus survival at 10 and 15 d, respectively. Our results suggest potential for developing a SIGS approach to B. aeneus management—though further experiments are needed to more fully understand this potential.
Strategic Approach, Advances, and Challenges in the Development and Application of the SIT for Area-Wide Control of Aedes albopictus Mosquitoes in Reunion Island
Authors: Gouagna Louis Clément , Damiens David , Oliva Clélia F. , Boyer Sébastien , Le Goff Gilbert , Brengues Cécile , Dehecq Jean-Sébastien , Raude Jocelyn , Simard Frédéric , Fontenille Didier
Published: November 2020

The global expansion of Aedes albopictus, together with the absence of specific treatment and vaccines for most of the arboviruses it transmits, has stimulated the development of more sustainable and ecologically acceptable methods for control of disease transmission through the suppression of natural vector populations. The sterile insect technique (SIT) is rapidly evolving as an additional tool for mosquito control, offering an efficient and more environment-friendly alternative to the use of insecticides. Following the devastating chikungunya outbreak, which affected 38% of the population on Reunion Island (a French overseas territory in the southwest of the Indian Ocean), there has been strong interest and political will to develop effective alternatives to the existing vector control strategies. Over the past 10 years, the French Research and Development Institute (IRD) has established an SIT feasibility program against Ae. albopictus on Reunion Island in collaboration with national and international partners. This program aimed to determine whether the SIT based on the release of radiation-sterilized males is scientifically and technically feasible, and socially acceptable as part of a control strategy targeting the local Ae. albopictus population. This paper provides a review of a multi-year and a particularly broad scoping process of establishing the scientific and technological feasibility of the SIT against Ae. albopictus on Reunion Island. It also draws attention to some prerequisites of the decision-making process, through awareness campaigns to enhance public understanding and support, social adoption, and regulatory validation of the SIT pilot tests.
Tidal Supplementary Control Schemes-Based Load Frequency Regulation of a Fully Sustainable Marine Microgrid
Authors: Fayek Hady H. , Mohammadi-Ivatloo Behnam
Published: November 2020

The world is targeting fully renewable power generation by the middle of the century. Distributed generation is the way to increase the penetration level of renewable energies. This paper presents load frequency control of a hybrid tidal, wind, and wave microgrid to feed an isolated island. This research is a step towards 100% renewable energy communities in remote seas/oceans islands. The wave and tidal generation systems model are presented. The study presents load frequency control through three supplementary control strategies: conventional integrators, fractional order integrator, and non-linear fractional order integrator. All the controllers of the microgrid are designed by using a novel black widow optimization technique. The applied technique is compared to other existing state-of-the-art algorithms. The results show that the black widow non-linear fractional integrator has a better performance over other strategies. Coordination between the unloaded tidal system and blade pitch control of both wind and tidal systems are adopted in the microgrid to utilize the available reserve power for the frequency support. Simulation and optimization studies are performed using the MATLAB/SIMULINK 2017a software application.
Haploidentical Stem Cell Transplantation in Lymphomas—Expectations and Pitfalls
Authors: Mariotti Jacopo , Bramanti Stefania , Santoro Armando , Castagna Luca
Published: November 2020

T-cell replete Haploidentical stem cell transplantation (Haplo-SCT) with Post-transplant cyclophosphamide (PT-Cy) is an emerging therapeutic option for patients with advanced relapsed or refractory lymphoma. The feasibility of this platform is supported by several retrospective studies showing a toxicity profile that is improved relative to umbilical cord blood and mismatched unrelated donor (UD) transplant and comparable to matched unrelated donor transplant. In particular, cumulative incidence of chronic graft-versus-host disease (GVHD) is reduced after Haplo-SCT relative to UD and matched related donor (MRD) transplant thanks to PT-Cy employed as GVHD prophylaxis. This achievement, together with a similar incidence of acute GVHD and disease relapse, results in a promising advantage of Haplo-SCT in terms of relapse-free/GVHD free survival. Unmet needs of the Haplo-SCT platform are represented by the persistence of a not negligible rate of non-relapse mortality, especially due to infections and disease relapse. Future efforts are warranted in order to reduce life-threatening infections and to employ Halo-SCT with PT-Cy as a platform to build new immunotherapeutic strategies.
Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men
Authors: Riachy Ruba , McKinney Kevin , Tuvdendorj Demidmaa R.
Published: November 2020

Exercise has been proposed to increase serum testosterone concentrations. The analysis of existing literature demonstrates a large degree of variability in hormonal changes during exercise. In our manuscript, we summarized and reviewed the literature, and concluded that this variability can be explained by the effect of numerous factors, such as (a) the use of different types of exercise (e.g., endurance vs. resistance); (b) training intensity and/or duration of resting periods; (c) study populations (e.g., young vs. elderly; lean vs. obese; sedentary vs. athletes); and (d) the time point when serum testosterone was measured (e.g., during or immediately after vs. several minutes or hours after the exercise). Although exercise increases plasma testosterone concentrations, this effect depends on many factors, including the aforementioned ones. Future studies should focus on clarifying the metabolic and molecular mechanisms whereby exercise may affect serum testosterone concentrations in the short and long-terms, and furthermore, how this affects downstream mechanisms.
Introduction of a Comprehensive Diagnostic and Interdisciplinary Management Approach in Haematological Patients with Mucormycosis: A Pre and Post-Intervention Analysis
Authors: Risum Malene , Helweg-Larsen Jannik , Petersen Søren Lykke , Kampmann Peter , Overgaard Ulrik Malthe , El Fassi Daniel , Nielsen Ove Juul , Brabrand Mette , Rubek Niclas , Munksgaard Lars , Severinsen Marianne Tang , Nielsen Bendt , Gertsen Jan Berg , Gylfe Åsa , Hjort Ulla , Vourtsi Angeliki , Hare Rasmus Krøger , Arendrup Maiken Cavling
Published: November 2020

Mucormycosis is a life threatening infection in patients with haematological disease. We introduced a Mucorales-PCR and an aggressive, multidisciplinary management approach for mucormycosis during 2016–2017 and evaluated patient outcomes in 13 patients diagnosed and treated in 2012–2019. Management principle: repeated surgical debridement until biopsies from the resection margins were clean as defined by negative Blankophor microscopy, Mucorales-PCR (both reported within 24 h), and cultures. Cultured isolates underwent EUCAST E.Def 9.3.1 susceptibility testing. Antifungal therapy (AFT) (mono/combination) combined with topical AFT (when possible) was given according to the minimal inhibitory concentration (MIC), severity of the infection, and for azoles, specifically, it was guided by therapeutic drug monitoring. The outcome was evaluated by case record review. All patients underwent surgery guided by diagnostic biopsies from tissue and resection margins (195 samples in total). Comparing 2012–2015 and 2016–2019, the median number of patients of surgical debridements was 3 and 2.5 and of diagnostic samples: microscopy/culture/PCR was 3/3/6 and 10.5/10/10.5, respectively. The sensitivity of microscopy (76%) and Mucorales-PCR (70%) were similar and microscopy was superior to that of culture (53%; p = 0.039). Initial systemic AFT was liposomal amphotericin B (n = 12) or posaconazole (n = 1) given as monotherapy (n = 4) or in combination with isavuconazole/posaconazole (n = 3/6) and terbinafine (n = 3). Nine patients received topical amphotericin B. All received isavuconazole or posaconazole consolidation therapy (n = 13). Mucormycosis related six month mortality was 3/5 in 2012–2015 and 0/7 patients in 2016–2019 (one patient was lost for follow-up). Implementation of combination therapy (systemic+topical AFT/combination systemic AFT) and aggressive surgical debridement guided by optimised diagnostic tests may improve the outcome of mucormycosis in haematologic patients.
Barriers to Financial Innovation—Corporate Finance Perspective
Authors: Błach Joanna
Published: November 2020

This paper addresses the application of financial innovations from the corporate finance perspective. The objective is to identify and prioritize the main types of barriers to the implementation of financial innovations by nonfinancial firms. The motivation behind the study lies in the importance of financial innovations for the firms’ ability to create value. As proven by the extensive literature review, comprehensive studies on financial innovation applications by nonfinancial firms are relatively rare. To cover this cognitive gap, the theoretical argumentation followed by the discussion of results of the empirical research are presented in this paper. The paper provides the results of two-stage survey research, aiming to find opinions of financial managers (end-users) and experts (creators of innovation) on the main barriers to financial innovations in Poland. According to managers, the most important are exogenous barriers, including: (1) Unclear tax and accounting regulations, (2) complex construction of financial innovations, and (3) transaction costs related to their application. On the other side, the experts from financial institutions recognized the greater importance of endogenous factors such as: (1) Lack of sufficient knowledge about financial innovations and (2) the reluctance to change observable in many firms. This study contributes to the ongoing debate on financial innovations by adding the perspective of corporate financial strategy. It also offers insights into the potential actions (at the institutional and individual level) aiming to reduce the barriers and support the implementation of financial innovations by nonfinancial firms.
Additive Manufacturing of Cementitious Materials by Selective Paste Intrusion: Numerical Modeling of the Flow Using a 2D Axisymmetric Phase Field Method
Authors: Pierre Alexandre , Weger Daniel , Perrot Arnaud , Lowke Dirk
Published: November 2020

The 3D printing of concrete has now entered a new era and a transformation of the construction sector is expected to reshape fabrication with concrete. This work focuses on the selective paste intrusion method, which consists of bonding dry particles of aggregate with a cement paste. This innovative technique could lead to the production of very precise component for specific applications. The main obstacle to tackle in order to reach a high shape accuracy of high mechanical performances of 3D printing elements by selectively activating the material is the control of the distribution of the cement paste through the particle bed. With the aim to better understand the path followed by the solution as it penetrates a cut-section of the granular packing, two-dimensional numerical modeling is carried out using Comsol software. A phase-field method combined with a continuous visco-plastic model has been used to study the influence of the average grain diameter, the contact angle, and the rheological properties of cement pastes on the penetration depth. We compare the numerical modeling results to existing experimental results from 3D experiments and a one-dimensional analytical model. We then highlight that the proposed numerical approach is reliable to predict the final penetration of the cement pastes.
A New Kumaraswamy Generalized Family of Distributions with Properties, Applications, and Bivariate Extension
Authors: Tahir Muhammad H. , Hussain Muhammad Adnan , Cordeiro Gauss M. , El-Morshedy M. , Eliwa M. S.
Published: November 2020

For bounded unit interval, we propose a new Kumaraswamy generalized (G) family of distributions through a new generator which could be an alternate to the Kumaraswamy-G family proposed earlier by Cordeiro and de Castro in 2011. This new generator can also be used to develop alternate G-classes such as beta-G, McDonald-G, Topp-Leone-G, Marshall-Olkin-G, and Transmuted-G for bounded unit interval. Some mathematical properties of this new family are obtained and maximum likelihood method is used for the estimation of G-family parameters. We investigate the properties of one special model called the new Kumaraswamy-Weibull (NKwW) distribution. Parameters of NKwW model are estimated by using maximum likelihood method, and the performance of these estimators are assessed through simulation study. Two real life data sets are analyzed to illustrate the importance and flexibility of the proposed model. In fact, this model outperforms some generalized Weibull models such as the Kumaraswamy-Weibull, McDonald-Weibull, beta-Weibull, exponentiated-generalized Weibull, gamma-Weibull, odd log-logistic-Weibull, Marshall-Olkin-Weibull, transmuted-Weibull and exponentiated-Weibull distributions when applied to these data sets. The bivariate extension of the family is also proposed, and the estimation of parameters is dealt. The usefulness of the bivariate NKwW model is illustrated empirically by means of a real-life data set.
Fractal Generalization of the Scher–Montroll Model for Anomalous Transit-Time Dispersion in Disordered Solids
Authors: Sibatov Renat T.
Published: November 2020

The Scher–Montroll model successfully describes subdiffusive photocurrents in homogeneously disordered semiconductors. The present paper generalizes this model to the case of fractal spatial disorder (self-similar random distribution of localized states) under the conditions of the time-of-flight experiment. Within the fractal model, we calculate charge carrier densities and transient current for different cases, solving the corresponding fractional-order equations of dispersive transport. Photocurrent response after injection of non-equilibrium carriers by the short laser pulse is expressed via fractional stable distributions. For the simplest case of one-sided instantaneous jumps (tunneling) between neighboring localized states, the dispersive transport equation contains fractional Riemann–Liouville derivatives on time and longitudinal coordinate. We discuss the role of back-scattering, spatial correlations induced by quenching of disorder, and spatiotemporal non-locality produced by the fractal trap distribution and the finite velocity of motion between localized states. We derive expressions for the photocurrent and transit time that allow us to determine the fractal dimension of the distribution of traps and the dispersion parameter from the time-of-flight measurements.
Solving Generalized Equations with Bounded Variables and Multiple Residuated Operators
Authors: Cornejo M. Eugenia , Lobo David , Medina Jesús
Published: November 2020

This paper studies the resolution of sup-inequalities and sup-equations with bounded variables such that the sup-composition is defined by using different residuated operators of a given distributive biresiduated multi-adjoint lattice. Specifically, this study has analytically determined the whole set of solutions of such sup-inequalities and sup-equations. Since the solvability of these equations depends on the character of the independent term, the resolution problem has been split into three parts distinguishing among the bottom element, join-irreducible elements and join-decomposable elements.
Pain Characteristics and Associations with Quality of Life in Patients with Multiple Sclerosis in Lithuania
Authors: Veličkaitė Greta , Jucevičiūtė Neringa , Balnytė Renata , Laucius Ovidijus , Vaitkus Antanas
Published: November 2020

Background and objectives: Even though pain in multiple sclerosis (MS) patients is common and possibly associated with reduced quality of life, its exact prevalence and characteristics remain vaguely understood. We aimed to estimate the true extent of pain and its associations with quality of life in Lithuanian MS patients and to compare this data with that of a control group. Materials and Methods: Data were collected prospectively at the Department of Neurology, Lithuanian University of Health Sciences Kaunas Clinics. A face-to-face structured interview and a questionnaire were used to collect demographic and clinical data of the MS (n = 120) and control (n = 120) groups. The Expanded Disability Status Scale (EDSS) was used to quantify disability in the MS group. Scores ≥4/10 in the Douleur Neuropathique 4 questionnaire were classified as neuropathic pain. Patients were evaluated using the anxiety and depression subsets of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), the physical and mental component subsets of the Short Form-12 questionnaire (PSC-12 and MSC-12). Results: The MS and control groups did not differ in pain prevalence (76.7% vs. 65.9%, p = 0.064) or intensity. Lhermitte sign, lower limb, and face pain were more common in the MS group, whereas subjects in the control group were more often affected by lower back, neck, and joint pain. Neuropathic pain and pain lasting longer than 2 years were more common among pain-affected MS patients than among controls. MS patients with pain had higher EDSS, HADS-D, and HADS-A and lower PSC-12 scores than those without pain; however, no difference was found regarding the duration of MS or age. Males with MS and pain had higher MSC-12 and HADS-D scores in comparison to the same subset of females. Conclusions: Pain affects approximately three out of four patients with MS in Lithuania and is negatively associated with the mental and physical aspects of quality of life.
Application of Hydrophobic Alkylimidazoles in the Separation of Non-Ferrous Metal Ions across Plasticised Membranes—A Review
Authors: Ulewicz Malgorzata , Radzyminska-Lenarcik Elzbieta
Published: November 2020

Currently, a lot of attention is paid to polymer inclusion membranes (PIMs). Their particular advantages include effective support fixation, easy preparation, versatility, stability, good mechanical properties and good chemical resistance. The paper presents a review of the literature related to the applications of polymer inclusion membranes containing alkylimidazole derivatives as carriers in the processes of transporting ions of heavy and toxic metals, such as Zn(II), Cu(II), Cd(II), Co(II), Ni(II), and Mn(II). It has been proven that alkylimidazoles exhibit varying complex-forming properties towards metal ions, and that their properties (hydrophobic and alkaline) can be modified easily by changing the size of the alkyl group and its position in the imidazole ring, which allows obtaining efficiently working metal ion carriers. The stability of an imidazole derivative-metal ion complex determines the speed and selectivity of the process of transporting metal ions across polymer inclusion membranes. Also, the morphological structure of polymer inclusion membranes impacts the efficiency of the process involving the release and separation of metal ions.