bluuebunny/crossref_metadata_2025 huggingface dataset:
Expansion Of Natural Killer Cells and Efficacy Against Hematologic Malignancies
Authors: Wu Jinhan
Published: January 2024

The battle against cancer in human body relies heavily on natural killer (NK) cells. Therefore, NK cells have been showing great potential in cancer immunotherapy. Adoptive transfer of great amounts of NK cells and their cytotoxicity towards cancer cells are heavily researched because of the fact that the NK cells in patients are typically diminished in quantity and malfunctional because of pretreatment. In this review, we concentrate on the techniques for expanding the four main NK cell sources employed in adoptive cell transfer: peripheral blood, umbilical cord blood, NK cell lines and different types of stem cells. We also investigate the efficacy of NK cells derived from each cell source against hematologic malignancies by analyzing experimental data and propose possible reasons for the discrepancy. In the last part, we touch on the prospect of genetically modified NK cells. We concluded that each cell source has its own advantages and drawbacks in expansion and efficacy. In addition, by combining with cytokines, monoclonal antibodies, and other treatments, the cytotoxicity of NK cells in vivo against hematologic malignancies can be enhanced.
Role of Inflammatory Cytokines in Schizophrenia
Authors: Jiang Qinyin
Published: January 2024

Schizophrenia is a complex psychological disorder with a prevalence rate that ranges from 0.16% to 1.21%. It affects individuals of different ages and genders, although the first onset of symptoms typically occurs during adolescence or young adulthood. Patients with schizophrenia often demonstrate impairments in cognition, emotion, and behavior, which can hinder their ability to interact with their surroundings. While the disease is persistent and chronic, most patients do not experience intellectual disabilities. Furthermore, schizophrenia places a heavy burden on society and the economy. As a result, there is a pressing need for extensive research on its etiology and pathogenesis, making it a prominent topic in psychiatric research. The neurotransmitter hypothesis, which suggests that schizophrenia may be associated with dysfunction in the dopamine system, has been widely utilized to study the pathogenesis of the disorder. Genetics, neuropathology, and neurotransmitter hypotheses provide important insights into the understanding of schizophrenia. However, further research is necessary to uncover the underlying causes and mechanisms of the disease fully. This review aims to provide a systematic introduction to the current understanding of schizophrenia, discuss the various hypotheses and findings related to its etiology and pathogenesis, and emphasize the role of the immune system in this disorder, thus improving the diagnosis, treatment, and prevention of schizophrenia. By exploring the immune system's involvement in schizophrenia, researchers can gain a more comprehensive understanding of the disease and develop novel interventions and treatments.
CAR T-Cell-Based Combination Therapy for Pancreatic Ductal Adenocarcinoma (PDAC)
Authors: Xing Yi
Published: January 2024

It is projected that by 2030, following the lung cancer, pancreatic cancer will rank among the deadliest cancers. Because of the limited initial symptoms and early diagnosis, PDAC has one of the most dismal prognosis among all types of malignancies. Therefore, it is crucial to develop promising treatments for PDAC cases. Genetically engineering the T lymphocytes to express designed chimeric antigen receptors (CAR) is an emerging direction, but the major hindrance is the complex tumor microenvironment (TME) that restricts its performance. This review paper discusses the existing combinations between CAR T-cell and other therapies, the challenges, and future improvements in promoting the therapeutic outcomes of PDAC. Multiple chemotherapeutic drugs remodel the complicated TME to upregulate the potency of T cells. Some radiotherapies augment tumor-associated antigen expression to increase the anticancer activities. Additionally, the cytotoxicity of the engineered T cells is enhanced by checkpoint inhibitor blockade (CPB). Oncolytic viruses (OVs) represent another novel approach in CAR T-cell combination. OVs stimulate cytokines, which then trigger the chemokines in CAR-T-cell regulations. Being well-versed in the potential concurrent therapies in CAR T-cell-based manner facilitates researchers in conducting future studies in a more targeted way towards PDAC.
Preface: 4th International Conference on Medical Imaging, Sanitation and Biological Pharmacy (MISBP 2023)
Authors: Mansfield Cornelius , Zou Gang
Published: January 2024

The 2023 4th International Conference on Medical Imaging, Sanitation and Biological Pharmacy (MISBP 2023) was successfully held during November 04-05, 2023 in Osaka, Japan. This conference aims to provide a platform for researchers and engineers to share their ideas, recent developments, and successful practices in medical imaging, sanitation, biomedical engineering, biochemistry, pharmacy, and human health.

The conference had 4 technical session and 4 poster sessions. Each keynote speech lasted 30-40 minutes, and authors presentation 8-10 minutes. Each presentation was included with questions and answers. MISBP 2023 became an effective communication platform for all the participants over the world. The conference proceeding is a compilation of the accepted papers and represent an interesting outcome of the conference.

We would like to acknowledge all of those who supported MISBP 2023. Especially we would like to thank the committee members and reviewers for their tremendous contribution in conference organization and peer review of the papers. We are sure that the proceedings will serve as an important research source of references and the knowledge, which will lead to not only scientific and engineering progress but also other new products and processes.

MISBP Conference Organizing Chair

Osaka, Japan
The Potential Risks of Lumbar Disk Herniation Treatment
Authors: Han Haoke
Published: January 2024

Lumbar disc herniation has now become a relatively common lumbar disease, and surgical treatment has gradually matured. Whether the surgical intervention should be judged according to the diagnosis of imaging or the symptoms of the patient has also become a problem. In addition to surgery, doctors generally recommend that patients undergo conservative treatment first, and physical therapy is the most commonly used. Physical therapy includes manual therapy, rehabilitation exercises, and traction. The root of the problem is that the measures doctors take for patients should be based on the symptoms and feelings of the patients. Some patients may not be suitable for the treatment methods or rehabilitation exercises, which will lead to aggravation of the disease. At present, there are many ways to treat lumbar disc herniation, but on the basis of everything, it is necessary to ensure that patients are treated conservatively because the human body has the ability to repair itself.
The Relationship Between Overfishing and The Global Shark Population
Authors: Luo Yiran , Yang Ruize
Published: January 2024

Sharks are the oldest species on Earth. Fossil records show that they roamed the ocean at least 420 million years ago. And modern sharks have been around for about 100 million years, which means they once lived with dinosaurs. Currently, there are over 500 species of sharks in the world. The oceanic shark population is impacted heavily by human pollution and fishing activities, the most serious of them is overfishing. Overfishing has caused a great loss of the shark population. Sharks are the second-most endangered vertebrate lineage after amphibians. According to the International Union for Conservation of Nature's (IUCN's) first global assessment, which classified them as critically endangered, endangered, or vulnerable based on the Red List of Threatened Species' criteria, one-quarter of them were in danger of going extinct. Sharks are now really in jeopardy due to this setback. The fact that marine sharks have long generation periods and many of species have intrinsically poor rates of population expansion is another contributing cause to this loss. This makes them really weak while facing destructive human activities. The research will pay its attention on the relationship between the causes of the shark population’s loss, the worldwide shark trade market, and how can human beings do to prevent the rate from keeping increasing. At last, this kind of activity can be stopped worldwide.
Molecular Characterization of Zinc Transporter Proteins (ZnT) and the Roles in Diseases
Authors: Zhong Yongyi
Published: January 2024

As an essential trace element, zinc is required by the human body, and it is associated with various physiological activities. It can impact body development, brain function, bone growth, reproductive health and immune function. Zinc deficiency can cause many diseases, whereas excess zinc can lead to cytotoxicity as well. Thus, in the human body, it is significant to sustain zinc homeostasis. Zinc transporter protein (ZnT) is reported to take responsibility for zinc transport from cytoplasm to extracellular or organelle. It includes nine family members, and they are widely localized in diverse tissues. Furthermore, some ZnTs function not only in zinc transport but also in modulating as well. Besides, ZnTs are shown to be involved with the occurrence and development of several diseases, including transient neonatal zinc deficiency (TNZD), Parkinson’s disease (PD) and others. This paper will review the molecular characteristics of ZnTs and their recent research progress on diseases, which may offer new insight into treatment.
Brain-Computer Interface Based Neuromodulation on Treatment of Depression
Authors: Li Yijiang
Published: January 2024

Major Depressive Disorder (MDD) represents a significant societal burden, with traditional first-line treatments often falling short. This pressing issue has spurred the exploration of neuromodulation therapies, demonstrating superior efficacy compared to conventional pharmaceutical interventions. The present review provides a rigorous evaluation of four advanced neuromodulation techniques: Focal Electrically Administered Seizure Therapy (FEAST), Transcranial Magnetic Stimulation (TMS), Intermittent Theta-Burst Stimulation (iTBS), and Magnetic Seizure Therapy (MST). A comprehensive analytical comparison is offered, focusing on their efficacy, feasibility, economic considerations, and underlying mechanisms. Among these therapies, iTBS, integrated with Brain-Computer Interface (BCI) systems, has emerged as notably effective, with clinical trials indicating an average 80% efficacy at a reduced economic cost. FEAST and MST, supported by recent research, also exhibit strong efficacy, around 60%, although with more pronounced side effects. TMS, in contrast, exhibits a slightly reduced efficacy but is promising due to its minimal side effects. The review further delves into the transformative role of increasingly sophisticated BCI technologies in addressing previously identified challenges of neuromodulation therapy, such as adverse side effects, time-consuming procedures, and high costs. These technological advancements are elucidated, emphasizing their contribution to more precise therapy delivery and an enhanced patient experience. The review culminates in illuminating a pathway for the harmonious integration of neuromodulation therapies with traditional psychopharmacological treatments, positioning this integrative approach as a groundbreaking paradigm poised to redefine the landscape of depression treatment.
Comparison of Traditional Chinese Medicine Treatment and Western Medicine Treatment of Tennis Elbow (External Humeral Epicondylitis)
Authors: He Jiliang
Published: January 2024

Tennis elbow is a chronic strain disease characterized by lateral elbow joint pain and limited movement. There are a variety of treatment methods, mainly consist of surgical treatment and non-surgical treatment, surgical treatment has quick effect, while non-surgical treatment has a low recurrence rate and is minimally invasive or non-invasive. Under different theoretical systems of TCM and Western medicine, non-surgical treatment methods are also different. Common treatment methods of traditional Chinese medicine include acupuncture, massage, traditional Chinese medicine fumigation, etc. Extracorporeal shock wave and drug use. This article reviewed and summarized many domestic and foreign literatures on the treatment methods of external humeral epicondylitis, and listed the similarities and differences in clinical treatment methods of external humeral epicondylitis under two different treatment systems of traditional Chinese medicine and Western medicine.
A Study of Treatment Approaches for Children and Adolescents with Avoidant/Restrictive Food Intake Disorder
Authors: Fan Shuhan
Published: January 2024

Eating disorders negatively affect people’s health. Common eating disorders including binge eating disorder, anorexia, and bulimia nervosa which are widely researched by researchers. New eating disorder, avoidant/restrictive food intake disorder (ARFID) introduced in DSM-5 which received less attention from researchers and the public. The research presented that children and adolescents are disproportionally affected by ARFID, but currently, there is a lack of understanding of ARFID and its treatments. This systemic review extracts relevant studies from three databases to identify available treatments of ARFID and assess the efficacy of each treatment. It aims to bring the public’s attention to ARFID, preventing delays in seeking healthcare services. Also, this review is designed to guide healthcare professionals for ARFID treatment selections as well as bringing suggestions for future research directions. Three databases (PubMed, Cochrane Library, Scopus) were searched from 2013–2023 for studies that relevant to treatments for children and adolescents with ARFID. 7 studies were included in this review. It reported that treatments for managing children and adolescents with ARFID in all 7 studies presented positive effects in the reduction of ARFID symptoms. The biggest limitation of the finding was the small sample size. The evidence showed that all different types of ARFID treatment had an improvement in ARFID symptoms. However, the definitive conclusion cannot be drawn before conducting research with an increased sample size. Children and adolescents’ motivation for changing eating behaviours and parent education can partially determine the efficacy of treatments.
The Regulation of FOXP3 Expression and Its Therapeutic Potential in Non-Small Lung Cancer
Authors: Jiang Muhan
Published: January 2024

Non-small cell cancer (NSCLC) is today one of the most threatening malignant tumors, and it is still rarely cured by current standard therapies with a high mortality rate. The transcription factor Forkhead box p3 (FOXP3) is a potential molecular target for NSCLC since it has been identified with an oncogenic effect in the tumor microenvironment (TME). It is well known that FOXP3 expression could characterize the regulatory T cells (Treg), which plays a critical role in regulating anti-tumor immune responses in TME. Through analyzing the basic mechanisms of FOXP3 and Treg in distinct tumor tissues, they have been found with contradictory expression and the frequency in different TME. In NSCLC, the suppressive function of Treg to immune systems and frequency of FOXP3 is accumulated to promote the development of tumors. Most recently, accumulating evidence reveals the therapeutic potential of targeting FOXP3 and the related signaling pathways in the treatment of NSCLC patients. Although unsolved side effects and limitations that still must be considered when targeting FOXP3 and FOXP3-related proteins, there is no doubt that they are potential therapeutic applications for NSCLC treatment. The main objective of this review is to mention the structure, function and recent progress in treatment targeting FOXP3 and FOXP3-related signaling pathways, especially to therapies with immune checkpoint inhibitors.
Metabolic Regulation of Natural Killer Cells
Authors: Guo Rui
Published: January 2024

Natural Killer cells, known as NK cells act crucially in protection of anti-tumor and anti-virus activities as innate lymphocytes. Due to its unique characteristics such as recognizing and attacking stressed cells independently, and bridge connection function between innate immunity and adaptive immunity, it possesses profound potential and prospect in immunotherapy. However, due to resistance existing in combination of therapies and undeclared metabolism pathways, its application in clinical trials has been underestimated. Metabolic configurations are adopted to support functions, which is dynamic when immune cells experience the procedure of metabolic reprogramming in responses. In order to support anti-tumor functions, NK cells up regulate both glycolysis and OXPHOS, leading to the alternative of energy metabolism structure and ATP relief upon activation with pro-inflammatory cytokines. After activation, what exactly determines phenotypes and destiny of NK cells is also being considered as the classification standard of receptors distribution is found both vague and not universally applicable. Additionally, author focus on metabolic factors in solid cancer treating, which are highly relative to tumor microenvironment (TME). TME provides many molecules for the prevention of potential effector function of normal cells (especially immune cells) and protection of tumor. For example, substances such as TGF-β are capable to not only downregulate NK cell cytotoxicity and cytokine secretion but also reduce the extent of metabolism and proliferation, and also induce effector NK cells to increase the production of ILC1-like characteristics. This review will discuss NK cells’ metabolic foundation to realize NK cell effector functions and analyze the relationship between phenotypes, NK cell fates and metabolism. Also, basing on impaired functions, immune suppression and resistance of joint therapies, the author will discuss different pathways and possible treating targets and therapies in order to boost cancer treatment progress such as adoptive NK cell therapy, bio- or tri- engager therapy and CAR-NK therapy.
Research On Genetic Therapy with CRISPR Genome Directed Editing Technology
Authors: He Junxi
Published: January 2024

CRISPR/Cas is an acquired immune response mediated by RNA that is ubiquitous in bacteria and archaea. CRISPR/Cas9 is considered a new generation of gene editing technology due to its simple design, high editing efficiency and strong adaptability. This article summarizes the development and application of CRISPR/Cas technology in gene editing field, and analyzes its main impact factors for the reference of researchers.
Classification and Application of the Personalized Glioblastoma Organoids
Authors: Xie Yihua
Published: January 2024

The severe survival rate of glioblastoma especially the recurrent glioblastoma, has directly shown the aggressiveness of glioblastoma and meanwhile, showing the lack of the standardized therapies can be effectively and directly against the glioblatoma in clinical situations. The tumor organoids technology has developed rapidly and the personalized glioblastoma organoids have already been used in several researches about the therapies of glioblastoma as an appropriate model. Comparing with the existed models used in past researches, the tumor organoids show irreplaceable features which will contribute a lot in the researches of glioblastoma including the recapitulation of the microenvironment and the cellular communication of parental tumors. In some researches, personalized tumor organoids were used in drug-screening tests and the final-result show high similarity to the actual situations. The drawbacks of common models greatly hamper the development of novel therapies of glioblastoma because of its inaccuracy in the aspects of the recapitulation and experiment results which will prove a invalid therapy in clinical situations as effective and finally deviate the researches from the correct way. Personalized glioblastoma organoids can be divided into 2 types which is the 3D bioprinting organoids and the patient-derived glioblastoma organoids and each of these maintains own advantages in practical situations. Furthermore, personalized glioblastoma organoids can be stored for much more longer time than the existed organoids which also show the possibilities of applying the glioblastoma organoids into the biobank in order to assist further researches.
Applications, Efficacies, Potential Side Effects, and Expectations of CAR-T Cell Therapy in the Treatment of Acute Lymphoblastic Leukemia
Authors: Jia Yundan
Published: January 2024

CAR-T cell therapy is a highly effective and powerful treatment for acute lymphoblastic leukemia (ALL), showcasing remarkable efficacy in combating this disease. Currently, several CAR-T cell therapies are available for ALL, including Kymriah and Yescarta. CAR-T is a novel targeted therapy for tumor treatment, marking a shift in modern medicine from molecular therapy to cellular therapy. ALL is a malignant blood disorder characterized by an abnormal proliferation of immature white blood cells known as lymphoblasts. These abnormal cells may be found in bone marrow, lymph nodes, spleen, and other organs. Acute lymphoblastic leukemia (ALL) predominantly affects adolescents and children, with a higher incidence observed in males. Although immunotherapy has shown promising efficacy in hematologic malignancies, the emergence of antigen escape poses a significant obstacle, limiting its use in treating solid tumors. Extensive scientific research is underway to improve the construction and manufacturing techniques of CAR-T cells and investigate novel cell configurations. This review aims to summarize the applications, efficacy, side effects, and expected outcomes of CAR-T therapy in treating ALL. It also explores strategies to enhance CAR-T therapy and provides insights into its current status and future directions in the background of ALL.
CAR-T Therapy in Diffuse Large B-Cell Lymphoma
Authors: Chen Shiying , Geng Yiming
Published: January 2024

CAR-T is a genetically engineered autologous T cell as a "live drug" targeting CD19. As a new tumor treatment method in recent years, CAR-T has been quite effective in DLBCL treatment. In the process of tumor treatment, the tumor appeared immune escape, so modern scientists modified T cells into CART through experiments. The common targets of CAR-T are CD19, BCMA, etc., and the appearance of targets has been reduced to a certain extent The emergence of immune escape, and the application of dual-target CAR-T further mitigated this problem. However, when CAR-T therapy is implemented in vivo, it is affected by the tumor micro environment, which inhibits its treatment effect. This article discusses the role and positive influence of multi-target cart in the treatment of NHL discuss and explore the negative influence of its efficacy in the micro environment.
Threats Faced by Red-crowned Cranes and Solutions
Authors: Huang Liuyi
Published: January 2024

With the development of the times, more and more people are destroying the natural ecological environment and hunting wild animals for various purposes, such as social economic and agricultural development, personal desire for money and so on. One victim of human bad conduct is the red-crowned crane, as an example. Red-crowned cranes are now suffering from many threats that have led to a sharp decline in its population. If humans do not do something in time, the number of red-crowned cranes will gradually decrease until they become extinct. Therefore, this article will mainly focus on analyzing the threats faced by red-crowned cranes and the solutions that can help change the situation of red-crowned cranes which includes four threats and four solutions or methods that can help to protect the Whooping Crane. In order to better protect red-crowned cranes, increase their numbers, and safeguard some ecological environments while aiding red-crowned cranes, such as wetlands. This article is helpful for people to be able to understand the issues that red-crowned cranes face and to know the solutions.
Component Level Failure Analysis of Mounting Strap Joint Fitted on Vehicle Engine Exhaust After-Treatment System
Authors:   Department of Mechanical Engineering, Motilal Nehru Institute of Technology Prayagraj (U.P), India., Gupta Amulya , Deshmukh Kishor P ,   Department of Automotive Engineering, VIT University, Prayagraj (U.P), India., Sarpate Chandraprakash S ,   Department of Mechanical Engineering, IIT Delhi, India., Kadam Kiran A. ,   Department of Mechanical Engineering, RIT Rajaram Nagar, India., Gupta Sunil Kumar ,   Department of Mechanical Engineering, Motilal Nehru Institute of Technology, Prayagraj (U.P), India.
Published: January 2024

Exhaust Gas Processors (EGP) or Exhaust After Treatment Systems (EATS) are usually mounted on vehicle chassis or engine body with the help of mounting straps due to its ease of installation. It is prescribed for any industry to manufacture an optimized design of strap joint and duly test it before making an entry to the market. There is no standard method available to be followed by the industry for strap validation at an earlier stage. Most of the strap joint designed and tested based either on MAST test (done in the later stages) or on the experience. So, to test the strap joint at an earlier stage there is a need to design a component level strap joint validation method with a goal to assess the durability of strap joint vulnerable to fatigue failures due to vibration over-amplification in a bracketed after-treatment assembly while able of detecting any design flaws and eliminating or reducing numbers of potential test induced failures. The objective of this work is to define and document a systematic approach for component level strap joint validation method used to mount after treatment system components. Due to geometrical complexity and nature of material, geometrical nonlinearity and material nonlinearity were considered in the analysis. Also, for getting the most realistic results contact nonlinearity was also considered. And finally, out of various approaches investigated, an approach which was able to replicate failures in a more exact manner comparable to assembly level test was recommended as the component level strap validation method.
Factors Affecting the E-learning Experience of the College Students in a General Education Course
Authors:   https://orcid.org/0009-0009-4803-5142 paraune@xu.edu.ph Department of Economics, Xavier University-Ateneo de Cagayan Corrales Avenue, Cagayan de Oro City, Philippines, B. Araune Paolo
Published: January 2024

E-learning has emerged as the primary response for the continuity of education during the COVID-19 pandemic. This mode of learning relies on digital devices and emphasizes accessibility to the internet, the primary conduit for information. This research explores the impact of college students’ gender, year level, scholarship status, monthly family income, and monthly internet expenditure on their e-learning experience in a general education course. Employing a descriptive methodology and quantitative research design, data was collected using a survey questionnaire based on the Demand-Driven Learning Model (DDLM) and a 4-point Likert scale, validated with Cronbach’s Alpha. The sample size of 251 respondents was determined using Cochran’s formula and selected through stratified random sampling. Results revealed significant differences in students’ e-learning experiences based on gender (content, delivery, service, and outcome), year level (content, delivery, and outcome), scholarship status (service), and monthly internet expenditure (service). No significant difference was found in terms of monthly family income. The study recommends applying the collected data to enhance factors influencing the quality of students’ e-learning experiences, encompassing content, delivery, service, and outcome. These findings contribute additional evidence, information, arguments, and perspectives. The paper’s structure, design, and methodology can serve as a model for other e-learning courses offered at the university. Keywords: education; pandemic; Demand-Driven Learning Model (DDLM); Likert scale; Philippines
A Narratology of Parents Scaffolding Children in the New Normal
Authors:   https://orcid.org/0009-0007-4509-0336, https://orcid.org/0000-0003-1148-2706 joceldivinagracia26@gmail.com, maryannronith.libago@kcast.edu.ph Kapalong College of Agriculture, Sciences and Technology Maniki, Kapalong, Philippines, D. Divinagracia Jocel , P. Libago Mary Ann Ronith
Published: January 2024

This qualitative study employing a narrative research approach aimed to explore the experiences of five (5) parents from Kapalong West District of Kapalong, Davao del Norte, as they navigated the challenges of assisting their elementary school children in the new normal setting. Using a narratological approach, the study delved into the narratives of the participants to identify the causes of their difficulties and the lessons and reflections gained from their experiences. The findings revealed that the parents were involved in children’s learning prior to the pandemic and had additional responsibility to teach and assist children during the new normal. Participants described their journey in teaching their elementary children as difficult due to insufficient time and children being distracted. Notwithstanding these difficulties, parents gleaned valuable lessons in cultivating positive connections with their children and enhancing their patience. They also developed a newfound appreciation for the noble and satisfying aspects of teaching. This study emphasizes the crucial need to support parents in their evolving roles as educators, underscoring the significance of comprehending their narratives and perspectives. Such understanding is vital for enhancing educational outcomes during challenging times and can serve as a foundation for future initiatives aimed at addressing the concerns of parents navigating the multifaceted role of a teacher. Keywords: elementary students, narratology approach, parents, qualitative research, scaffolding
In Constant Search for Affection: Untold Narratives of Juvenile Delinquents or “SUKARAP” in Davao Region
Authors:   https://orcid.org/0000-0003-1148-2706, https://orcid.org/0000-0003-2440-212X, https://orcid.org/0000-0003-3345-7659 maryannronith.libago@kcast.edu.ph, jobelle.jajalla@kcast.edu.ph, royojames07@gmail.com Kapalong College of Agriculture, Sciences and Technology Maniki, Kapalong, Philippines, P. Libago Mary Ann Ronith , B. Jajalla Jobell , C. Royo James
Published: January 2024

“Sukarap,” derived from “stagger,” reflects uncontrolled movements while walking. This qualitative-phenomenological study focuses on the challenges faced by Sukarap members in the Davao Region. Examining their involvement, reasons, challenges, and coping mechanisms, the research engaged 14 Sukarap members through interviews and discussions. Participants revealed experiences of painful initiation, exposure to vices, street riots, and life-threatening situations. Coping strategies included diversion, peer support, and ignoring challenges. Insights from Sukarap members highlighted belongingness, learning, and opportunities for change. In conclusion, the study emphasizes the importance of education and affection in nurturing the optimal development of delinquent juveniles seeking attention and affection outside their families. Keywords: gang, gangsterism, plight, Sukarap, stories to tell
Financial Inclusion And Financial Well-Being Of Ambulant Vendors In Kapalong, Davao Del Norte
Authors:   https://orcid.org/0009-0001-0812-7108, https://orcid.org/0009-0008-1190-2161, https://orcid.org/0009-0003-2830-8285 dynamaeclaro@gmail.com, ghuing.gabule@gmail.com, elenaa19maria@gmail.com Kapalong College of Agriculture, Sciences and Technology Maniki, Kapalong, Philippines, L. Claro Dyna Mae , S. Gabule Daisy , G. Litob Maria Elena
Published: January 2024

The study explores the level of financial inclusion and financial well-being of ambulant vendors in Kapalong, Davao del Norte. This study utilized the descriptive-correlation design utilizing the adaptive questionnaire, which was validated by the panel of experts in both independent and dependent variables. Statistical tools used in the study were mean and Pearson-r for the treatment of the data collected and gathered. Eighty-eight respondents from 14 barangays in Kapalong were selected using random sampling. The results revealed that the five indicators of financial inclusion: financial literacy, accessibility, availability, affordability, and usage were rated high. It also revealed that the mean of the indicators from financial well-being got a high descriptive level, which includes financial preparedness, beliefs of credit limits, and risky indebtedness behavior. The result showed that there is a significant relationship between financial inclusion and the financial well-being of ambulant vendors in Kapalong, Davao del Norte. This concludes that all measures of financial inclusion used in this study have a high relationship with financial well-being. Therefore, the two variables were highly significant to each other. Keywords: financial inclusion, financial well-being, descriptive-correlation design, ambulant vendors, Kapalong, Davao del Norte
The Analysis of Work-Life Balance on Job Performance among Medical Office Practitioners
Authors:   https://orcid.org/0009-0009-9743-3462, https://orcid.org/0009-0004-6988-1317, https://orcid.org/0009-0007-7446-9433, https://orcid.org/009-0008-7489-9895, https://orcid.org/0000-0002-3118-3079, https://orcid.org/0009-0006-4267-0566, I. Aet Aira Joy , Concon Jean Mae Joy , B. Dasas Michellie , L. Manlaunan Mary Joy , D. Daga-As Jandy , P. Ganiera Grace ,   airajoyaet27@gmail.com, jeanmayjoyc@gmail.com, mich.bautistadasas@gmail.com, mjmanlaunan2205@gmail.com, dagaasjandy@gmail.com, 0009-0006-4267-0566 Kapalong College of Agriculture, Sciences and Technology Maniki, Kapalong, Philippines
Published: January 2024

This research aims to explore how work-life balance affects job performance among medical office practitioners in Barangay Maniki, Kapalong, and Davao del Norte, using a descriptive-correlational approach. The respondents in this study were medical office practitioners residing at the mentioned address. There were 156 total respondents in this study. The results gathered from this study showed that the average level of work-life balance is 3.92. The level of job performance among medical office practitioners is very high, with an overall mean of 4.25. The test for the significant impact of work-life balance on job performance among medical office practitioners in Barangay Maniki, Kapalong, Davao del Norte, yielded an R-value of 0.52 and a probability value of 0.001 at a 0.05 level of significance. In relevance to this, the study concludes that work-life balance directly influences the job performance of medical office practitioners. Thus, it is suggested that hospitals must strengthen the work-life balance of their office employees to enhance their performance in their duties. Keywords: work-life balance, job performance, medical office practitioners
Alingawngaw sa Boses na Pagal: Kwalitatibong Pag-Aaral sa Danas ng mga mag-Aaral sa Pagsasalita sa Birtuwal na Hapag
Authors:   https://orcid.org/0000-0005-4871-3960, https://orcid.org/0009-0008-1170-3234, https://orcid.org/0009-0006-5493-1080 arangesseanjoshua@gmail.com, coniecerna@gmail.com, aisasalinasbasay@gmail.com Kapalong College of Agriculture, Sciences and Technology Maniki, Kapalong, Philippines, C. Aranges Sean Joshua , B. Cerna Conie , S. Basay Aisa
Published: January 2024

Layunin ng kwalitatibong pag-aaral na ito na alamin ang karanasan ng 14 na piling mag-aaral sa pagsasalita sa birtuwal na hapag mula sa ikalawang taon ng Batsilyer sa Sekondaryang Edukasyon Mayoryang Filipino sa Kapalong College of Agriculture, Sciences and Technology (KCAST) patungkol sa kanilang takot at pagkabalisa sa nasabing konteksto. Ang pananaliksik ay gumamit ng kwalitatibong disenyo na may penomenolohiyang pagdulog, kung saan isinagawa ang pinalalimang panayam at pangkatang talakayan, at isinagawa ang masusing pagsusuri sa maingat na pagkuha ng mga datos. Ang pananaliksik ay nakatuon sa tatlong pangunahing katanungan: una, ang karanasan ng mga mag-aaral sa pagsasalita sa birtuwal na hapag, kabilang ang takot sa negatibong paghuhusga, kawalan ng koneksyon sa birtuwal na hapag, kompiyansang magsalita kapag off-cam, at paninibago sa bagong modalidad. Pangalawa, paano nakayanan ng mga mag-aaral ang kanilang takot at pagkabalisa, kasama ang paghahanda sa birtuwal na talakayan, pagiging mahinahon sa pagsasalita, pagsasanay sa sarili, at pagtataglay ng positibong kamalayan. At panghuli, ang pananaw ng mga mag-aaral na may takot at pagkabalisa, kabilang ang tiwala sa sarili, aktibong pakikilahok, inspirasyon mula sa pamilya at mga kaibigan, at kawilihan sa motibasyon ng guro. Susing-salita: Alingawngaw sa boses na pagal, danas sa pagsasalita sa birtuwal na hapag, online class, bayan ng Kapalong
Building Leaders for Tomorrow: A Comprehensive Succession Planning Model for Higher Education Institutions
Authors:   https://orcid.org/0000-0002-9221-2937, https://orcid.org/0000-0003-4755-3510 camatog.dennis@paranaquecitycollege.edu.ph, sario.jay@paranaquecitycollege.edu.ph Parañaque City College Coastal Road Corner Victor Medina Street, San Dionisio, Parañaque City, C. Camatog Dennis , A. Sario Jay
Published: January 2024

This study delves into the practice of succession planning in higher education institutions, with a particular focus on the localized context of the Province of Cavite, Philippines. Employing a grounded theory research design, the study utilizes structured interviews as its primary research method to extract insights from key personnel directly. The investigation centers on the key attributes, including organizational commitment, skills assessment, talent evaluation, leadership development, selection processes, transition implementation, and integration of succession planning. The findings uncovered a spectrum of commitment levels among personnel, identified skill gaps in potential successors, underscored limitations in leadership development initiatives, and highlighted the subjective nature of leadership selection criteria. A crucial observation was the misalignment between the goals of succession planning and the broader institutional objectives. However, it’s important to note that the qualitative approach adopted in this study may limit the generalizability of its findings. In conclusion, this research underscores the significant role of organizational culture in effective succession planning, offers practical recommendations applicable to higher education institutions globally, and calls for further research in this area. The study’s uniqueness lies in its localized perspective, comprehensive objectives, and contribution to understanding the influence of organizational culture in the context of succession planning within the higher education sector. Keywords: Educational Leadership and Management; Succession Planning, Organizational Culture; Grounded Theory, Structured Interviews; Province of Cavite, Philippines
The Role of Gratitude in Psychological Well-Being across Gender and Educational Strands
Authors:   https://orcid.org/0000-0002-4803-1004, https://orcid.org/0009-0005-6616-3499 mwapano@xu.edu.ph, 20190018581@my.xu.edu.ph Xavier University – Ateneo de Cagayan Cagayan de Oro City, Philippines, R Wapaño Mary Rachelle , A Baroquillo Laira Dee
Published: January 2024

This study utilizes a quantitative approach to examine the impact of gratitude on psychological well-being across respondents of different genders and educational backgrounds. The research methodology employed is correlational and descriptive. Data was gathered from 164 participants with the use of the Gratitude Questionnaire (GQ-6) and the Depression Anxiety Stress Scales-21 (DASS-21). The study began with conducting a descriptive analysis to estimate the distribution of gratitude. This was followed by performing correlational analysis and multiple regression to investigate the association between gratitude and well-being. The findings demonstrate a strong inverse relationship between gratitude scores and DASS-21 outcomes, highlighting gratitude as a valid indicator of psychological well-being across many demographic groups. Cultural and experiential characteristics, rather than gender or educational level, appeared to have an impact on the differences in how gratitude is expressed. The study’s methodology, which utilizes self-report measures, has several limitations. To address these limitations, future research should adopt a longitudinal strategy and employ different data-gathering methods. The findings underscore the significance of gratitude in fostering psychological well-being, emphasizing its capacity as a moral gauge, motivator, and enforcer in social settings. This emphasizes the importance of gratitude in promoting communal unity and personal well-being, underlining its value in academic discourse on happiness. Considering the increasing worldwide prevalence of mental health issues, these observations provide significant viewpoints on the cultural dynamics of gratitude and its potential application in educational and therapeutic environments. Keywords: Gratitude, psychological well-being, gender, educational strands
The Scientology of Hypothesis Testing in Empirical Research: Emphasizing Economic Significance
Authors: Mayondi Moses , Mulenga Richard
Published: January 2024

Over the decades, scientists across various disciplines have cautioned against the practice of over-emphasizing statistical significance at the expense of economic or practical significance. It seems that empirical researchers in the 21st century have not heeded the caution because meeting statistical significance targets continue to take precedence over the wider discovery and publication of scientifically objective findings. Statistically insignificant results are rarely reported, in part due to publication bias towards statistically significant findings. The survey finds that although large sample sizes are widely used in empirical economics and finance research, none of the surveyed papers adopted alternative methods of hypothesis testing, such as Bayesian methods. All of them explicitly or implicitly used the classical Fisher’s hypothesis testing methods. This study finds that discussions on economic significance in nearly all papers (almost 97% of papers) only wrote one sentence or two regarding the magnitude of the effect of the regressors and a declaration that the findings were economically significant. We recommend that to enhance research credibility, other methods of hypothesis testing such as Bayesian methods, should be adopted. Journal article publishers should encourage the publication of statistically insignificant empirical findings. Economic or practical significance should be emphasized and comprehensively discussed.
Üçüncü Umumi Müfettişliğinin Kurulması ve Üçüncü Umumi Müfettişi Tahsin Uzer’in Iğdır ile İlgili Yaptığı Çalışmalar
Authors: ÖZKAL İbrahim
Published: January 2024

Umumi Müfettişlikler Osmanlı Devleti’nin idari sisteminde 19. yüzyılın sonlarında yer almıştır. Bu dönemde kurulan Umumi Müfettişlikler kuruldukları bölgelerde yapılan ıslahatları denetlemek, asayişi sağlamak, idari, adli, sosyal ve ekonomik alanlarda çalışmalar yapmak amacıyla kurulmuştur. Umumi Müfettişlikler Milli Mücadele döneminde Büyük Millet Meclisi tarafından 1921 yılında kabul edilen Teşkilat-ı Esasiye Kanunu’nda da yer almıştır. Ancak Milli Mücadele’nin devam ettiği o günkü şartlarda uygulanamamıştır. Cumhuriyetin ilanından sonra 25 Haziran 1927 tarihinde Umumi Müfettişlik Teşkiline Dair Kanun’un kabul edilmesiyle Umumi Müfettişlikler kurularak uygulamaya konulmuştur. 1927-1947 yılları arasında beş Umumi Müfettişlik kurulmuştur. Doğu Anadolu’da Üçüncü Umumi Müfettişliğinin kurulmasında Başbakan İsmet İnönü’nün 1935 yılında Doğu Anadolu ve Karadeniz Bölgesi’ne yaptığı gezi etkili olmuştur. İsmet İnönü’nü doğu gezisi sonrasında hazırladığı rapor göz önüne alınarak bölgede var olan sorunların yerinde tespiti ve çözümünü kolaylaştırmak amacıyla bölgede Umumi Müfettişlik kurulması kararı alınmıştır. Buna göre 23 Ağustos 1935 tarihinde Üçüncü Umumi Müfettişliği kurulmuş ve müfettiş olarak Tahsin Uzer atanmıştır. Bu makalede Üçüncü Umumi Müfettişliğinin kurulması ve Üçüncü Umum Müfettişi Tahsin Uzer’in Iğdır ile ilgili yaptığı çalışmalar ele alınmıştır. Çalışmada arşiv belgelerinden, ulusal ve yerel basından ve konu ile ilgili araştırma eserlerinden faydalanılmıştır.
A INTERFERÊNCIA DO FUTURO SUBJUNTIVO DO PORTUGUÊS NA APRENDIZAGEM DO TEMPO VERBAL DO SUBJUNTIVO COM VALOR FUTURO EM ESPANHOL POR ESTUDANTES BRASILEIROS
Authors: D'Albuquerque Juliana Barboza
Published: January 2024

Este trabalho investigou a influência do futuro do subjuntivo da língua materna nas orações subordinadas do presente do subjuntivo com valor futuro na língua espanhola por estudantes brasileiros. Os participantes foram divididos em dois níveis, intermediário e avançado. Descobrimos que os alunos do nível intermediário têm um desempenho superior, cometendo menos erros e mais acertos do que os alunos do nível avançado em sentenças do modo subjuntivo com valor futuro introduzido por “quando” devido à influência do modo futuro do subjuntivo do português brasileiro. Como os alunos de nível avançado estão nos últimos períodos do curso e não recebem mais instrução formal baseada na gramática contrastiva, a interferência da língua materna aparece com mais força, percebendo-se uma estrutura de fossilização nos futuros professores brasileiros de espanhol como língua estrangeira (ELE).
INTEGRAÇÃO DE TECNOLOGIAS DIGITAIS NO AMBIENTE ESCOLAR: FORMAÇÃO DE PROFESSORES E METODOLOGIAS ATIVAS
Authors: Meroto Monique Bolonha das Neves , Brandão Eliezer Lemos , Da Silva Freilan Pereira , Demuner Jocelino Antonio , Paniago Larissa Almeida Ferreira , França Rina Silva , Santos Silvana Maria Aparecida Viana , Feitosa Valdiléia Cordeiro Araújo
Published: January 2024

Neste artigo é explorado o impacto da inserção de tecnologias digitais no ambiente escolar, tanto na formação dos professores quanto na aplicação de metodologias ativas de ensino. A análise se concentra na confluência entre tecnologia educacional e estratégias pedagógicas inovadoras, investigando as formas pelas quais os educadores podem ser habilitados a usar eficazmente a tecnologia em suas metodologias de ensino e como essas ferramentas digitais podem ser harmonizadas com as metodologias ativas para aprimorar a experiência de aprendizado dos alunos. Através de pesquisa qualitativa de revisão bibliográfica o objetivo geral é analisar o impacto da integração de tecnologias digitais no ambiente escolar sobre a formação de professores e a implementação de metodologias ativas, visando aprimorar os processos de ensino e aprendizagem. Os objetivos específicos são: examinar as transformações nas práticas pedagógicas decorrentes da integração de tecnologias digitais, conceituar e definir as metodologias ativas e avaliar a eficácia da formação docente em tecnologias digitais e metodologias ativas, considerando os desafios e oportunidades que emergem dessa integração no contexto educacional contemporâneo. Os capítulos abordam a explicação das metodologias ativas de ensino, destacando a importância no contexto educacional e a relação entre as metodologias ativas de ensino, enfatizando como essas abordagens influenciam e moldam as práticas pedagógicas dos professores. Por fim, pressupõe-se que o estudo enriquece o conhecimento já existente e estabelece a base para investigações futuras, proporcionando percepções importantes para educadores, criadores de políticas educacionais e acadêmicos, além de esboçar diretrizes inovadoras para o avanço da educação na era digital.