bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding design-based learning context and the associated emotional experience
Authors: Zhang Feiran , Markopoulos Panos , Bekker Tilde , Paule-Ruíz Mpuerto , Schüll Martine
Published: October 2020

Educational settings are emotional places where students experience diverse emotions in relation to academic activities and their outcomes. Emotions, in turn, greatly influence students’ learning process and engagement. Research on emotions in Design-Based Learning (DBL) has so far been coarse-grained examining how students evaluate their overall feelings towards the DBL project. As yet, little is known regarding how specific DBL activities influence students’ emotional experience. Therefore, we report a three-month field study of a DBL project involving 30 middle school students (aged 13–14) addressing dual research purposes: (1) to faithfully reconstruct the manner and sequence of activities during DBL from a fine-grained perspective; and (2) to examine the relationship between these activities and students’ emotional experience. This study used a mixed research method and collected multiple data sources, including experience sampling surveys, classroom observations, and interviews. The research outcomes in this study are multiple. First, this paper reveals detailed inspection regarding the types of task students performed, the strategies of shifting, and executing tasks during the process student experienced. Second, this paper identifies specific types of activities that have a significant positive or negative relationship with students’ emotional experiences. Derived from reported empirical evidence in the present study, this paper furtherly proposes an Activity-and-Affect model of DBL. This model provides a fine-grained description of DBL activity as continuous along three dimensions: task (design thinking process, project management, social interaction) task strategy (single-tasking vs. multitasking), and collaboration strategy (individual or group). Our analysis highlights the variability in how different DBL activities can be associated with different emotions.
A simplified approach to control cell adherence on biologically derived in vitro cell culture scaffolds by direct UV-mediated RGD linkage
Authors: Porras Hernández A. M. , Pohlit H. , Sjögren F. , Shi L. , Ossipov D. , Antfolk M. , Tenje M.
Published: October 2020

In this work, we present a method to fabricate a hyaluronic acid (HA) hydrogel with spatially controlled cell-adhesion properties based on photo-polymerisation cross-linking and functionalization. The approach utilises the same reaction pathway for both steps meaning that it is user-friendly and allows for adaptation at any stage during the fabrication process. Moreover, the process does not require any additional cross-linkers. The hydrogel is formed by UV-initiated radical addition reaction between acrylamide (Am) groups on the HA backbone. Cell adhesion is modulated by functionalising the adhesion peptide sequence arginine–glycine–aspartate onto the hydrogel surface via radical mediated thiol–ene reaction using the non-reacted Am groups. We show that 10 × 10 µm2 squares could be patterned with sharp features and a good resolution. The smallest area that could be patterned resulting in good cell adhesion was 25 × 25 µm2 squares, showing single-cell adhesion. Mouse brain endothelial cells adhered and remained in culture for up to 7 days on 100 × 100 µm2 square patterns. We see potential for this material combination for future use in novel organ-on-chip models and tissue engineering where the location of the cells is of importance and to further study endothelial cell biology.
Motif: an open-source R tool for pattern-based spatial analysis
Authors: Nowosad Jakub
Published: October 2020

Context

Pattern-based spatial analysis provides methods to describe and quantitatively compare spatial patterns for categorical raster datasets. It allows for spatial search, change detection, and clustering of areas with similar patterns.

Objectives

We developed an R packagemotifas a set of open-source tools for pattern-based spatial analysis.

Methods

This package provides most of the functionality of existing software (except spatial segmentation), but also extends the existing ideas through support for multi-layer raster datasets. It accepts larger-than-RAM datasets and works across all of the major operating systems.

Results

In this study, we describe the software design of the tool, its capabilities, and present four case studies. They include calculation of spatial signatures based on land cover data for regular and irregular areas, search for regions with similar patterns of geomorphons, detection of changes in land cover patterns, and clustering of areas with similar spatial patterns of land cover and landforms.

Conclusions

The methods implemented inmotifshould be useful in a wide range of applications, including land management, sustainable development, environmental protection, forest cover change and urban growth monitoring, and agriculture expansion studies. Themotifpackage homepage ishttps://nowosad.github.io/motif.
Upscaling the interplay between diffusion and polynomial drifts through a composite thin strip with periodic microstructure
Authors: Cirillo Emilio N. M. , de Bonis Ida , Muntean Adrian , Richardson Omar
Published: October 2020

We study the upscaling of a system of many interacting particles through a heterogenous thin elongated obstacle as modeled via a two-dimensional diffusion problem with a one-directional nonlinear convective drift.
Assuming that the obstacle can be described well by a thin composite strip with periodically placed microstructures, we aim at deriving the upscaled model equations as well as the effective transport coefficients for suitable scalings in terms of both the inherent thickness at the strip and the typical length scales of the microscopic heterogeneities. Aiming at computable scenarios, we consider that the heterogeneity of the strip is made of an array of periodically arranged impenetrable solid rectangles and identify two scaling regimes what concerns the small asymptotics parameter for the upscaling procedure: the characteristic size of the microstructure is either significantly smaller than the thickness of the thin obstacle or it is of the same order of magnitude.
We scale up the diffusion–polynomial drift model and list computable formulas for the effective diffusion and drift tensorial coefficients for both scaling regimes. Our upscaling procedure combines ideas of two-scale asymptotics homogenization with dimension reduction arguments. Consequences of these results for the construction of more general transmission boundary conditions are discussed. We illustrate numerically the concentration profile of the chemical species passing through the upscaled strip in the finite thickness regime and point out that trapping of concentration inside the strip is likely to occur in at least two conceptually different transport situations: (i) full diffusion/dispersion matrix and nonlinear horizontal drift, and (ii) diagonal diffusion matrix and oblique nonlinear drift.
The Limits of Theoretical Disagreements in Jurisprudence
Authors: Dyrda Adam , Gizbert-Studnicki Tomasz
Published: October 2020

This paper discusses the “positivistic” idea of the limits of law in various contexts: the conceptual problem of the “limits of law”, the limits of legal interpretation and the limits of theoretical disagreements in jurisprudence. In the latter case, we briefly show how contemporary “reflective” or “critical” positivist theories approach the possibility and limits of disagreements over the “grounds” of law. In what follows, we argue that these theories, which argue for a form of an “institutional” limit for admissible “legal” reasons as built upon theories of basic concepts or normative theories of interpretation, are themselves actually underdetermined by “legal culture” or, so to speak, a “folk theory of law”. In the final section, we outline how a folk theory of law constrains both conceptual and interpretive enterprises in jurisprudence.
Using scaffolding to formalize digital coach support for low-literate learners
Authors: Schouten Dylan G. M. , Massink Pim , Donker Stella F. , Neerincx Mark A. , Cremers Anita H. M.
Published: October 2020

In this study, we attempt to specify the cognitive support behavior of a previously designed embodied conversational agent coach that provides learning support to low-literates. Three knowledge gaps are identified in the existing work: an incomplete specification of the behaviors that make up ‘support,’ an incomplete specification of how this support can be personalized, and unclear speech recognition rules. We use the socio-cognitive engineering method to update our foundation of knowledge with new online banking exercises, low-level scaffolding and user modeling theory, and speech recognition. We then refine the design of our coach agent by creating comprehensive cognitive support rules that adapt support based on learner needs (the ‘Generalized’ approach) and attune the coach’s support delay to user performance in previous exercises (the ‘Individualized’ approach). A prototype is evaluated in a 3-week within- and between-subjects experiment. Results show that the specified cognitive support is effective: Learners complete all exercises, interact meaningfully with the coach, and improve their online banking self-efficacy. Counter to hypotheses, the Individualized approach does not improve on the Generalized approach. Whether this indicates suboptimal operationalization or a deeper problem with the Individualized approach remains as future work.
A Framework for Compensating Climate Change Damages
Authors: Wündisch Joachim
Published: October 2020

Anthropogenic climate change is expected to contribute to mass migration from many different regions. Heyward and Ödalen (2016) propose a tailor-made migration option for victims of total territorial loss: a Free Movement Passport for the Territorially Dispossessed (PTD). The PTD presents a significant advancement over standard proposals for individual migration in response to total territorial loss. However, I argue that the compensatory obligations of states are more restrictive than the PTD scheme assumes (sec. 5), and that the contents of the right to compensation of the territorially dispossessed are not as far-reaching as required by it (sec. 6). In response to these difficulties, I argue that its purpose is better served by means of collective migration and propose a Passport for Territorially Dispossessed Collectives, which is also well positioned to serve as a framework for compensating a range of other climate-change related losses (sec. 9).
Elaborating a people-centered approach to understanding sustainable livelihoods under climate and environmental change: Thang Binh District, Quang Nam Province, Vietnam
Authors: Mabon Leslie , Nguyen Song Tung , Pham Thi Tram , Tran Thi Tuyet , Le Hong Ngoc , Doan Thi Thu Huong , Hoang Thi Ngoc Ha , Mueller-Hirth Natascha , Vertigans Stephen
Published: October 2020

This paper explores the maintenance of livelihoods under climate, environmental, and economic development pressures, through the case of Thang Binh District in Quang Nam Province, Vietnam. Within widespread recognition of the need to link sustainable livelihoods approaches with climate change adaptation, there is growing awareness of the importance of people-centered approaches which keep the diverse experience, capabilities, and knowledges of the most vulnerable at the heart of sustainable livelihoods thinking. In response, this paper explores the conditions for changes in modes of livelihoods in a case study area where top-down strategies for sustainable livelihoods are met with residents’ diverse experiences of vulnerability, and where climate and environmental changes shape residents’ relations with the landscape. The research is undertaken via interviews with residents, farmers/fishers, and local government officials. Our study finds that whilst government-led initiatives for sustainable livelihoods are welcomed in the locality, inflexible policies can make it challenging for the most vulnerable people to access support. Moreover, residents see the capacity to live with and respond to extreme weather events as a critical component of maintaining a sustainable livelihood. Our findings reinforce international literature, showing that ‘the poor’ are not a homogenous category, and illustrate the importance of attention to the smallest levels of government who are tasked with putting sustainable livelihoods initiatives into practice in relation to people’s daily lives.
Lanreotide autogel/depot in advanced enteropancreatic neuroendocrine tumours: final results of the CLARINET open-label extension study
Authors: Caplin Martyn E. , Pavel Marianne , Phan Alexandria T. , Ćwikła Jarosław B. , Sedláčková Eva , Thanh Xuan-Mai Truong , Wolin Edward M. , Ruszniewski Philippe ,   on behalf of the CLARINET Investigators
Published: October 2020

Purpose

In the phase III CLARINET study (NCT00353496), lanreotide autogel/depot (lanreotide) significantly improved progression-free survival (PFS) vs placebo in patients with non-functioning intestinal or pancreatic neuroendocrine tumours (NETs). The aim of CLARINET open-label extension (OLE) (NCT00842348) was to evaluate long-term safety and efficacy of lanreotide in these patients.

Methods

Patients from the CLARINET study were eligible for the OLE if they had stable disease (irrespective of treatment group) or progressive disease (PD) (placebo-treated patients only). All patients in the OLE received lanreotide 120 mg every 28 days. Computed tomography or magnetic resonance imaging scans were conducted every 6 months and assessed locally for PD (the final scan was also assessed centrally).

Results

Overall, 89 patients took part in the OLE (lanreotide, n = 42; placebo, n = 47). Median (range) exposure to lanreotide in patients who received lanreotide in the core study and OLE (LAN–LAN group) was 59.0 (26.0–102.3) months. In this group, the overall incidences of adverse events (AEs) and treatment-related AEs were lower in the OLE than in the core study. Median [95% CI] PFS in the LAN–LAN group was 38.5 [30.9; 59.4] months. In placebo-treated patients with PD at the end of the core study, time to death or subsequent PD during the OLE was 19 [10.1; 26.7] months.

Conclusions

This study provides new evidence on the long-term safety profile and sustained anti-tumour effects of lanreotide autogel/depot in indolent and progressive metastatic intestinal or pancreatic NETs.
The Role of Fertility in the Demography of Grandparenthood: Evidence from Italy
Authors: Di Gessa Giorgio , Bordone Valeria , Arpino Bruno
Published: October 2020

Grandparents play an important role in their family’s lives. However, little is known about the demography of grandparenthood. Given dramatic recent changes in fertility, we explore the role of number of children and age at first birth in the timing of the transition into grandparenthood focusing on Italy, a country with well-known North-South fertility differentials. We used data from the 2009 Italian Survey ‘Family and Social Relations’ (N = 10,186) to estimate median ages of grandparenthood across three birth cohorts of parents (1920–29; 1930–39; 1940–49). Findings show an overall postponement of age of grandparenthood of 5 years, shifting for women from early to mid- or late-50s (in the South and North, respectively). Such postponement is largely driven by family compositional changes: although the age of grandparenthood among mothers of three or more children has not changed much over cohorts, the percentage of mothers with such characteristic decreased significantly. The heterogeneity in experiencing the transition to grandparenthood has implications for intergenerational transfers and other roles in later life.
Timescales and Magnitude of Water Quality Change in Three Texas Estuaries Induced by Passage of Hurricane Harvey
Authors: Walker Lily M. , Montagna Paul A. , Hu Xinping , Wetz Michael S.
Published: October 2020

Tropical cyclones represent a substantial disturbance to water quality in coastal ecosystems via storm surge, winds, and flooding. However, evidence to date suggests that the impacts of tropical cyclones on water quality are generally short-lived (days-months) and that the magnitude of the disturbance is related to proximity to storm track. Discrete and continuous water samples were collected in three Texas estuaries before and after Hurricane Harvey made landfall in 2017. Of the three estuaries, the Guadalupe Estuary and its watershed received the highest rainfall totals and wind speeds. An ephemeral increase in salinity was observed (mean of 9.8 on 24 August 2017 to a peak of 32.1 on 26 August 2017) due to storm surge and was followed by a rapid decrease to < 1 as floodwaters reached the estuary. Salinity returned to pre-storm levels within 1 month. During the low salinity period, bottom water hypoxia developed and lasted for 9 days. In all three estuaries, there was an increase in inorganic nutrients post-Harvey, but the nutrients largely returned to pre-storm baseline levels by winter. The lack of long-term water quality impacts from Harvey despite its severity corroborates previous findings that estuarine water quality tends to return to baseline conditions within days to a few months after storm passage.
Management of pediatric forearm fractures: what is the best therapeutic choice? A narrative review of the literature
Authors: Caruso G. , Caldari E. , Sturla F. D. , Caldaria A. , Re D. L. , Pagetti P. , Palummieri F. , Massari L.
Published: October 2020

Purpose

This narrative review intends to summarize the most important and relevant data on diagnosis and treatment of pediatric forearm fractures and to describe the characteristics and advantage of each therapeutic option.

Methods

We conducted a literature research considering peer-reviewed papers (mainly clinical trials or scientific reviews) using the string “forearm fracture AND epidemiology” or “forearm fracture AND diagnosis or “ forearm fracture AND treatment” or “forearm fracture AND casting” or “forearm fracture AND surgery”. Studies were identified by searching electronic databases (MEDLINE and PubMed) till April 2020 and reference lists of retrieved articles. Only English-language articles were included in the review.

Results

Conservative management with cast immobilization is a safe and successful treatment option in pediatric forearm fractures. Surgical indication is recommended when an acceptable reduction cannot be obtained with closed reduction and casting. Surgical treatment options are intramedullary nail, plating and hybrid fixation.

Conclusions

There is not a unique consensus about fracture management and treatment. Further studies are necessary to create univocal guidelines about optimal treatment, considering new techniques and available technologies.
Resuscitation with an AED: putting the data to use
Authors: Bak M. A. R. , Blom M. T. , Koster R. W. , Ploem M. C.
Published: October 2020

The increased use of the automated external defibrillator (AED) contributes to the rising survival rate after sudden cardiac arrest in the Netherlands. When used, the AED records the unconscious person’s medical data (heart rhythm and information about cardiopulmonary resuscitation), which may be important for further diagnosis and treatment. In practice, ethical and legal questions arise about what can and should be done with these ‘AED data’. In this article, the authors advocate the development of national guidelines on the handling of AED data. These guidelines should serve two purposes: (1) to safeguard that data are handled carefully in accordance with data protection principles and the rules of medical confidentiality; and (2) to ensure nationwide availability of data for care of patients who survive resuscitation, as well as for quality monitoring of this care and for related scientific research. Given the medical ethical duties of beneficence and fairness, existing (sometimes lifesaving) information about AED use ought to be made available to clinicians and researchers on a structural basis. Creating a national AED data infrastructure, however, requires overcoming practical and organisational barriers. In addition, further legal study is warranted.
Moderate Temperature Treatment of Gas-Phase Volatile Organic Toluene Using NiO and NiO–TiO2 Nano-catalysts: Characterization and Kinetic Behaviors
Authors: Almomani Fares , Bhosale Rahul R. , Khraisheh Majeda
Published: October 2020

For the first time, the potential of Ni/NiO and NiO–TiO2 nano-catalysts for the oxidation of toluene under moderate temperatures was investigated. The nano-catalysts were prepared using the solution combustion synthesis method (SCSM) and the effect of the composition of nano-catalysts, the inlet toluene concentration $$([\text{C}_{7} {\text{H}}_{8}]_{in})$$

(

[

C
7

H
8

]

in

)

, the relative humidity (RH), and the temperature on the percentage of toluene conversion ($$\% {\text{TN}}_{Conv.} )$$

%

TN

C
o
n
v
.

)

were subsequently examined. Results revealed that the nano-catalysts synthesized with a low fuel-to-metal ratio produced pure NiO, which has significant catalytic activity toward the conversion of toluene. Conversely, the high fuel-to-metal ratio generated a nano-catalysts that contains a mixture of Ni/NiO or pure Ni with low activity toward the conversion of toluene. Adding NiO to TiO2 increased the surface area of the catalyst, augmented the catalyst active sites, enhanced the oxidation of toluene, and increased CO2 selectivity ($${\text{S}}_{{{\text{CO}}_{2} }}$$

S

CO
2

). NiO and NiO–TiO2 nano-catalysts exhibited higher reaction rates, significant catalyst turnover frequency, and low activation energy. The obtained results revealed that the SCSM is a promising synthesis method for producing NiO or NiO–TiO2 nano-catalysts, which can be employed successfully for the removal of toluene from gas streams.

Graphic Abstract
Robotic-assisted gastrectomy for gastric cancer: single Western center results
Authors: Marano Luigi , D’Ignazio Alessia , Resca Luca , Marrelli Daniele , Roviello Franco
Published: October 2020

A robotic approach to abdominal surgery procedures may improve postoperative outcomes compared to either open or laparoscopic approaches. The role of robotics for gastric surgery, however, is still being evaluated. A retrospective review of the prospectively maintained database for robotic gastric surgery at University of Siena between 2011 and 2020 was conducted. Data regarding surgical procedures, early postoperative outcomes, and long-term follow-up were analyzed. 38 patients underwent robotic partial or total gastrectomy. Conversion to open occurred in two patients (5.2%) due to locally advanced disease as well as difficult identification of primary lesion. Postoperative morbidity was 13.1% while no postoperative mortality was registered. The mean length of operation was 358.6 (220–650) minutes and the mean number of retrieved lymph nodes was 35.8 (range: 5–73). The median OS of all population was 70.9 months. The median 5-year OS for the patients with positive nodes was worse than that of patients without metastatic lymph nodes [51.4 months (95% CI 35.5–67.4) vs. 79.5 months (95% CI 67.1–91.8);p = 0.079]. The interesting results including postoperative morbidity as well as mortality rate, the surgical outcomes, and the 5-year OS, were to be acceptable considering the data recorded by previous studies on robotic gastrectomy. This study demonstrated that robotic gastrectomy is feasible and can be safely performed. However, further follow-up and randomized clinical trials are required to confirm the role of a robotic approach in gastric cancer surgery.
Experimental and Theoretical Determination of the Effective Penetration Depth of Ultrafast Laser Radiation in Stainless Steel
Authors: Metzner Daniel , Olbrich Markus , Lickschat Peter , Horn Alexander , Weißmantel Steffen
Published: October 2020

This study intends to present a simple two-temperature model (TTM) for the fast calculation of the ablation depth as well as the corresponding effective penetration depth for stainless steel by considering temperature-dependent material parameters. The model is validated by a comparison of the calculated to the experimentally determined ablation depth and the corresponding effective penetration depth in dependence on the pulse duration (200 fs up to 10 ps) and the fluence. The TTM enables to consider the interaction of pulsed laser radiation with the electron system and the subsequent interaction of the electrons with the phonon system. The theoretical results fit very well to the experimental results and enable the understanding of the dependence of the ablation depth and of the effective penetration depth on the pulse duration. Laser radiation with a pulse duration in the femtosecond regime results in larger ablation depths compared to longer-pulsed laser radiation in the picosecond regime. Analogously to the ablation depth, larger effective penetration depths are observed due to considerably higher electron temperatures for laser radiation with pulse durations in the femtosecond regime.
Making the anaesthetised animal into a boundary object: an analysis of the 1875 Royal Commission on Vivisection
Authors: Holmes Tarquin , Friese Carrie
Published: October 2020

This paper explores how, at the 1875 Royal Commission on Vivisection, the anaesthetised animal was construed as a boundary object around which “cooperation without consensus” (Star, in: Esterbrook (ed) Computer supported cooperative work: cooperation or conflict? Springer, London, 1993) could form, serving the interests of both scientists and animals. Advocates of anaesthesia presented it as benevolently intervening between the scientific agent and animal patient. Such articulations of ‘ethical’ vivisection through anaesthesia were then mandated in the 1876 Cruelty to Animals Act, and thus have had significant downstream effects on the regulation of laboratory animals in Britain and beyond. Constructing this ‘consensus’ around the anaesthetised animal, however, required first excluding abolitionists and inhumane scientists, and secondly limiting the interests of experimental animals to the avoidance of pain through anaesthesia and euthanasia, thereby circumventing the issue of their possible interest in future life. This consensus also served to secure the interests of vivisecting scientists and to limit the influence of public opinion in the laboratory to administrative procedure and scheduled inspection. The focus on anaesthesia was connected with discussions of what supporting infrastructures were required to ensure proper ethical procedure was carried out by scientists. In contrast to the much studied polarisation in British society between pro- and antivivisectionists after 1876, we understand the 1875 Commission as a conflict amongst scientists themselves, while also being an intra-class conflict amongst the ruling class (French in Antivivisection and medical science in Victorian society, Princeton University Press, Princeton, 1975).
The multiplex nature of global financial contagions
Authors: del Rio-Chanona R. Maria , Korniyenko Yevgeniya , Patnam Manasa , Porter Mason A.
Published: October 2020

As illustrated by the 2008 global financial crisis, the financial distress of one country can trigger financial distress in other countries. We examine the problem of identifying such “systemically important” countries (i.e., countries whose financial distress can trigger further distress), which is important for assessing global financial stability. Using data on bilateral financial positions that are split by asset type, we build a multiplex global financial network in which nodes represent countries, edges encode cross-country financial assets of various types, and layers represent asset types. We examine the temporal evolution of a measure of node importance known as MultiRank centrality, and we find that several major European countries decrease in rank and that several major Asian countries increase in rank since 2008. We then develop a multiplex threshold model of financial contagions in which a shock can propagate either within a layer or between layers. We find that the number of systemically important countries can be twice as large when we take into account the heterogeneity of financial exposures (i.e., when using a multiplex network) than in a contagion on an associated aggregate global financial network (i.e., on a monolayer network), as is often examined in other studies. We also study the extent to which buffers can reduce the propagation of financial distress. Our analysis suggests that accounting for both intralayer and interlayer propagation of contagions in a multiplex structure of financial assets is important for understanding interconnected financial systems of countries.
Effects of Testosterone Deficiency and Angiotensin II–Induced Hypertension on the Biomechanics of Intramural Coronary Arteries
Authors: Jósvai Attila , Török Marianna , Mátrai Máté , Hetthéssy Judit , Monori-Kiss Anna , Makk Jennifer , Székács Béla , Nádasy György L. , Várbíró Szabolcs
Published: October 2020

Background

Andropause and hypertension also increase the risk of coronary artery damage.

Aim

To investigate the effect of testosterone deficiency and hypertension on intramural coronary vessels.

Methods

4 groups of 8-week-old Sprague-Dawley rats were studied: control male (Co, n=10), orchidectomized male (OCT, n=13), angiotensin (AII) hypertensive male (AII, n=10), and AII hypertensive and OCT (AII + OCT, n=8). Surgical orchidectomy was performed, and an osmotic minipump was inserted for chronic angiotensin II infusion (100 ng/min/kg). After 4 weeks, spontaneous tone and biomechanical properties of the intramural coronary resistance artery were investigated in vitro, by pressure microarteriography.

Outcomes

Morphology and biomechanics of the intramural coronaries were evaluated: the outer diameter, wall thickness–to–lumen diameter ratio, and tangential wall stress in the contracted and relaxed states.

Results

The outer diameter was reduced in OCT and AII + OCT groups (on 50 mmHg 315 ± 20 Co; 237 ± 21 OCT; 291 ± 16 AII, and 166 ± 12 μm AII + OCT). The increased wall thickness–to–lumen diameter ratio resulted in lower tangential wall stress in AII + OCT rats (on 50 mmHg 19 ± 2 Co; 24 ± OCT; 26 ± 5 AII, and 9 ± 1 kPa AII + OCT). Spontaneous tone was increased in the hypertensive rats (AII and AII + OCT groups) (on 50 mmHg 7.7 ± 1.8 Co; 6.1 ± 1.4 OCT; 14.5 ± 3.0 AII, and 17.4 ± 4.1 % AII + OCT).

Clinical Implications

Andropause alone can be considered as a cardiovascular risk factor that will further exacerbate vascular damage in hypertension.

Strengths & Limitations

A limitation of our study is that it was performed on relatively young rats, and the conclusions might not apply to coronary remodelling in older animals with slower adaptation processes.

Conclusions

Testosterone deficiency and hypertension damage the mechanical adaptation of the vessel wall additively: double noxa caused inward eutrophic remodeling and increased tone.
Calcidius on Plato's Timaeus
Authors: Reydams-Schils Gretchen
Published: October 2020

This is the first study to assess in its entirety the fourth-century Latin commentary on Plato's Timaeus by the otherwise unknown Calcidius, also addressing features of his Latin translation. The first part examines the authorial voice of the commentator and the overall purpose of the work; the second part provides an overview of the key themes; and the third part reassesses the commentary's relation to Stoicism, Aristotle, potential sources, and the Christian tradition. This commentary was one of the main channels through which the legacy of Plato and Greek philosophy was passed on to the Christian Latin West. The text, which also establishes a connection between Plato's cosmology and Genesis, thus represents a distinctive cultural encounter between the Greek and the Roman philosophical traditions, and between non-Christian and Christian currents of thought.
Heinrich Schenker's Conception of Harmony
Authors: Wason Robert W. , Brown Matthew
Published: October 2020

The first detailed study of Schenker's pathbreaking 1906 treatise, showing how it reflected 2500 years of thinking about harmony and presented a vigorous reaction to Austro-Germanic music theory ca. 1900.
The Mappae Mundi of Medieval Iceland
Authors: Kedwards Dale
Published: October 2020

An innovative, interdisciplinary approach to the understudied Icelandic mappae mundi.
Political Journalism in London, 1695–1720
Authors: Marshall Ashley
Published: October 2020

A major history of the evolution of political journalism in the late Stuart and early Hanoverian period.
The maintenance of friendships after severe traumatic brain injury
Authors: Bertram Tennille , Togher Leanne , Power Emma , Douglas Jacinta
Published: October 2020

Objective:

The aim of this qualitative study was to understand processes involved in the maintenance and development of friendships after a person sustains a traumatic brain injury (TBI).

Method:

Four people with severe TBI from rural settings in Australia identified one-to-two friends to be interviewed. A total of nine friends participated in a semi-structured interview. Interviews were transcribed verbatim and data was analyzed using principles of grounded theory.

Results:

The overall conceptualisation that emerged from the data described the process of friends actively placing themselves within the friendship with the person with TBI. Two major processes were evident which enabled friends to actively place themselves within the friendship. They were (1) making sense of the TBI and its consequences and (2) maintaining normality in the friendship.

Conclusions:

Friendships can be maintained following a TBI when friends actively place themselves within the friendships. Friends are able to do this when they make sense of the TBI and its consequences and maintain normality. There are a variety of ways that friends achieve this.
Effectiveness of herbicides onLysimachia vulgaris: a 17-year case study
Authors: De Luccia Marisa R. , Peterson Ben , Bradshaw Michael J. , Tobin Patrick C.
Published: October 2020

Garden loosestrife (Lysimachia vulgarisL.), is an invasive wetland plant that is subject to management in King County, WA, USA. Large-scale management efforts are generally conducted using herbicides. In this case study, we analyzed 17 yr of monitoring and treatment data in four riparian areas in King County to estimate the rate of spread ofL. vulgarisand the efficacy of herbicidal treatments againstL. vulgarispopulations. In each area, herbicide treatments were applied annually. In three of the areas, the area infested withL. vulgarisdid not change over time, while in the fourth area populations ofL. vulgariswere spreading at a rate of 0.79 m2yr−1. There were a greater number of sampled locations infested withL. vulgarisover the 17-yr period, and because populations were either not spreading or spreading slowly, it is possible that populations were becoming more fragmented. There was no relationship between the percentage of the infested area treated with herbicides and the area infested in the following year. However, there was a negative relationship between the area treated and the percent change in the invaded area; specifically, in years when <80% of the infested area was treated, there was an increase in the percent change of the invaded area between the year of treatment and the following year. The results of this study suggest that at the current level of management effort, the spatial extent ofL. vulgarisdid not retract over the 17-yr study period.
ReducingEragrostis lehmannianapopulations by preparing seedbeds with unconventional tillage implements and seeding in a semiarid grassland
Authors: Morales-Nieto Carlos Raúl , Álvarez-Holguín Alan , Santellano-Estrada Eduardo , Villarreal-Guerrero Federico , Corrales-Lerma Raúl
Published: October 2020

The invasion of Lehmann lovegrass (Eragrostis lehmannianaNees) in rangelands of Chihuahua, Mexico, has resulted in a need for revegetation to recover lost forage productivity. Thus, new knowledge on generating alternatives to improve these invaded grasslands is of great importance. This study evaluated seedbeds prepared with unconventional tillage implements and seeded with a grass mixture to reduce the plant density ofE. lehmannianawhile increasing the productivity of an invaded semiarid grassland of Chihuahua. The unconventional tillage implements were: a Rangeland Harrow, which was used to prepare the Striped Harrowing and Full Harrowing seedbeds; Rangeland Rehabilitator, which was used to prepare the Deep-Stingray Subsoiler seedbed; and a Tandem-type Aerator Roller, which was used to prepare the Double-Digging Aeration seedbed. An area without tillage was left as a control. The seed mixture was composed of blue grama [Bouteloua gracilis(Willd. ex Kunth) Lag. ex Griffiths var. Hachita] (25%); sideoats grama [Bouteloua curtipendula(Michx.) Torr. ‘6107 Kansas’] (25%); green sprangletop [Leptochloa dubia(Kunth) Nees var. Van Horn] (5%); weeping lovegrass [Eragrostis curvula(Schrad.) Nees var. Ermelo] (40%), and Columbus grass [Sorghum almumParodi] (5%). The experiment was conducted across 4 yr, and the evaluation started at the second year. Plant density and dry matter (DM) production were evaluated per species. In the control plot, the plant density ofE. lehmannianaincreased approximately 180% from the 2nd to the 4th year (18 to 50 plants m−2). The use of unconventional tillage implements for seedbed preparation and the inclusion ofE. curvulain the seed mixture decreasedE. lehmannianadensity in more than 50% of plots and increased DM production in around 100% of plots. Considering the whole experimental period, in all the prepared seedbed treatments,E. curvulahad the highest establishment and DM production of all the seeded species. The native speciesB. gracilis,B. curtipendula, andL. dubiahad poor establishment in all the prepared seedbeds.
Consequences of Ventenata dubia 30 years postinvasion to bunchgrass communities in the Pacific Northwest
Authors: Jones Lisa C. , Davis Cleve , Prather Timothy S.
Published: October 2020

Ventenata [Ventenata dubia (Leers) Coss.], an invasive winter annual grass, negatively impacts grassland community composition and function in the Pacific Northwest. Ventenata dubia established in Palouse prairie (PP) and canyon grasslands (CG) of northern Idaho/eastern Washington in the mid-1980s to early 1990s. Understanding and comparing patterns of invasion can elucidate future trends as its range expands. We performed surveys in PP (2012 and 2013) and CG (2018) to assess V. dubia abundance. Specifically, we correlated species richness, Shannon diversity, rank abundance, and indicator species with no, low (<12.5%), and high (>12.5%) V. dubia cover. We used nonmetric multidimensional scaling analysis (NMDS) to visualize species similarities and associations with abiotic variables. In both ecoregions, V. dubia was very common, appearing in nearly 60% of 450 plots. When present, V. dubia cover averaged 26% (±2.3 SE) in PP and 19% (±1.8 SE) in CG. Indigenous plant species richness and diversity were lowest in plots with high V. dubia cover. In CG, this relationship held for nonindigenous species; in PP, nonindigenous plant richness and diversity were higher with high V. dubia cover. Ventenata dubia and other winter annual grasses (Bromus spp., medusahead [Taeniatherum caput-medusae (L.) Nevski]) were moderately associated according to the NMDS analysis. Indicator species analysis showed V. dubia was positively associated with nonindigenous winter annual grasses and negatively associated with indigenous low shrub species. Abiotic factors that explained V. dubia abundance included shallow soils and a south to west aspect. Overall, these findings indicate V. dubia can successfully invade both dry and relatively wet plant communities and is more abundant than other invasive annual grasses. We suggest these findings foreshadow what will happen in sagebrush steppe and Great Plains grasslands, regions where V. dubia recently became established.
Numerical Simulation Study on Battery-Casing Sealing Considering Rubber Aging
Authors: Huang Yijie , Guo Fei , Ke Yuchao , Wu Fangyong , Jia Xiaohong , Wang Yuming
Published: October 2020

Battery-casing sealing is the key factor for secure travel of new energy vehicles. We constructed a relatively accurate mechanical-simulation model by selecting a constitutive model, analyzing the influence of thermal elongation, verifying the grid-independence and comparing numerically by the pressure-measurement film on the basis of studying the physical performance of a certain type of sealing material that had been used in battery-casings after aging. Based on a porous-media model and combined with changes of macroscopic and microscopic contact characteristics of materials at different times after aging, the evolution rule of sealing performance with time was analyzed quantitatively by calculating the leakage. By analyzing the structure of circular arc bulge on the surface of sealing material, the radius of circular arc bulge with better sealing performance was obtained, which could reduce the leakage of sealing structure during the material’s lifecycle.
Research on Edge Surface Warping Defect Diagnosis Based on Fusion Dimension Reduction Layer DBN and Contribution Plot Method
Authors: Jianliang Sun , Mengqian Sun , Hesong Guo , Yan Peng , Jiang Ji , Lipu Xu
Published: October 2020

The edge surface warping defect seriously affect the surface quality of strips. In this paper, a technology for diagnosis of warping defects in hot-rolled strip based on data-driven methods is studied. Based on the mechanism analysis of the warping defects, the process parameters affecting the warping defects were sorted out and used as the original input parameters of the defect diagnosis model. Firstly, a diagnostic model that combines the deep belief network and contribution plots of each dimensionality reduction layer is proposed. The deep belief network that integrates each dimensionality reduction layer can predict product defects more accurately and stably than the traditional deep belief network. Meanwhile, on the basis of the pre-judgment model, the method of contribution plot is further introduced to trace the defects, and the comprehensive diagnosis function of model pre-judgment and traceability is realized. Finally, collected the production data from a hot rolling production line for a period of time. Tested the model and predicted a hit rate of 85%. The main influencing factors of edge surface warping defects were determined that the rate of defect decrease with the increase of furnace temperature. When the heating temperature of the second stage of the heating furnace is higher than 1160°C, the incidence of defects is significantly reduced. Defect rate is relatively low within 240min of total furnace time. With the first and third pass phosphorus removal equipment turned on, the incidence of defects was relatively low.
Semilinear elliptic equations involving mixed local and nonlocal operators
Authors: Biagi Stefano , Vecchi Eugenio , Dipierro Serena , Valdinoci Enrico
Published: October 2020

In this paper, we consider an elliptic operator obtained as the superposition of a classical second-order differential operator and a nonlocal operator of fractional type. Though the methods that we develop are quite general, for concreteness we focus on the case in which the operator takes the form − Δ + ( − Δ)s, with s ∈ (0, 1). We focus here on symmetry properties of the solutions and we prove a radial symmetry result, based on the moving plane method, and a one-dimensional symmetry result, related to a classical conjecture by G.W. Gibbons.
In defense of a divided opposition: programmatic distribution and ethnic minor party support
Authors: Carlson Elizabeth
Published: October 2020

Why do so many voters in African countries vote for minor ethnic parties instead of unifying into a powerful multi-ethnic opposition coalition? I present a model that demonstrates that as the incumbent devotes more resources to programmatic goods, which voters can access regardless of how they voted, the opportunity cost of voting for a sincerely preferred, but losing, candidate decreases. I provide experimental and cross-national observational evidence that voters are more likely to support a minor party as they perceive more or more valuable goods being distributed programmatically. Those who perceive poor distribution, or only clientelist distribution, instead vote strategically for a major opposition party. In general, support for minor parties increases along with positive outcomes and approval of the incumbent.
Determinants of smallholder farmers’ decisions on fertilizer use for cereal crops in the Ethiopian highlands
Authors: Tefera Tewodros , Elias Eyasu , van Beek Christy
Published: October 2020

This study identified decision variables influencing fertilizer adoption and optimal fertilizer rates among smallholder farmers in the Ethiopian highlands. The fertilizer adoption and fertilizer use were examined in four regional states using a questionnaire survey, which was administered to 2880 farm households. A double hurdle model was used to analyze factors influencing the two independent decisions of adoption of fertilizers and use of fertilizers. The model estimates of the first hurdle revealed that the probability of fertilizer adoption increased by 1.2% as household education status improved, by 1.4% for an increased number of active family members, by 5.6% with improved access to credit, by 3.4% with cooperative membership, by 3.3% with an increase in farm size, by 4.6% when soil and water conservation practices are employed, and by 3.4% when agroecology of the farm is located in the medium to highland zone. Conversely, the probability of fertilizer adoption reduced by 0.9% for an increase in family size, 0.6% with 1 km distance from all-weather road, 1.6% for a kilometer further to farm plots, and 0.9% for an increase in number of parcels. The intensity of use of fertilizers was influenced by education status of the household head, family size, access to credit, membership to cooperatives, use of crop rotation, annual income, number of farm plots owned, use of soil and water conservation, and agroecology. Therefore, a concerted effort is needed to encourage fertilizer adoption and optimum fertilizer use intensity by improving households’ resource endowment, institutional capacity to deliver services, and infrastructure development.
Genesis of high-Ni olivine phenocrysts of the Dali picrites in the Central Emeishan large igneous province
Authors: Cai Wen-Chang , Zhang Zhao-Chong , Zhu Jiang , Santosh M. , Pan Rong-Hao
Published: October 2020

The Emeishan large igneous province (ELIP) in SW China is considered to be a typical mantle-plume-derived LIP. The picrites formed at relatively high temperatures in the ELIP, providing one of the important lines of argument for the role of mantle plume. Here we report trace-element data on olivine phenocrysts in the Dali picrites from the ELIP. The olivines are Ni-rich, and characterized by high (>1.4) 100×Mn/Fe value and low (<13) 10 000×Zn/Fe value, indicating a peridotite-dominated source. Since the olivine–melt Ni partition coefficient (KDNiol/melt) will decrease at high temperatures and pressures, the picrites derived from peridotite melting at high pressure, and that crystallized olivines at lower pressure, can generate high concentrations of Ni in olivine phenocrysts, excluding the necessity of a metasomatic pyroxenite contribution. Based on the Al-in-olivine thermometer, olivine crystallization temperature and mantle potential temperature (TP) were calculated atc. 1491°C andc. 1559°C, respectively. Our results arec. 200°C higher than that of the normal asthenospheric mantle, and are consistent with the role of a mantle thermal plume for the ELIP.