bluuebunny/crossref_metadata_2025 huggingface dataset:
Conceptual foundations of the new public health
Authors: Frenk Julio , Gómez-Dantés Octavio
Published: January 2023

This paper discusses the origins and content of the framework that guided the creation of the Center for Public Health Research in 1984 and the modernization of the School of Public of Health of Mexico, established in 1922. These two institutions eventually merged with the Center for Research in Infectious Disease to create, in 1987, the National Institute of Public Health of Mexico, one of the leading institutions of higher education and research in public health in the developing world.
Elección de proveedores de servicios de atención y necesidades de salud de la población mexicana, 2021
Authors: Colchero M Arantxa , Gómez Rouselinne , Bautista-Arredondo Sergio
Published: January 2023

Objetivo. Estimar la asociación entre la elección de pro­veedores de servicios de atención y las necesidades de salud de la población. Material y métodos. Se utilizaron datos de la Encuesta Nacional de Salud y Nutrición 2021 sobre Covid-19. Resultados. Las necesidades agudas (infeccio­nes respiratorias, diarrea y Covid-19) representan 48% del total; 21% crónicas (control, seguimiento o diagnóstico de diabetes, hipertensión, gastritis, cáncer); 12% necesidades de prevención (vacunación, chequeo, control prenatal); 7% eventos agudos no infecciosos que incluyen lesión física, dolor de cabeza, fiebre, y 4% el resto. La población elige atención privada o pública de forma diferenciada dependiendo del tipo de necesidad de salud. Para necesidades agudas sólo 25% se atiende en el sector público. Para enfermedades crónicas, agudas no infecciosas y de prevención, la proporción que se atiende en sector público es mayor, incluida la población sin seguridad social. Conclusiones. Los resultados de este estudio serán de utilidad para que la reforma en el sistema de salud pueda reforzar los servicios públicos que requieran más recursos.
Resilience and risk factors associated to depressive symptoms in Mexican healthcare workers during the Covid-19 pandemic
Authors: Durand-Arias Sol , Carmona-Huerta Jaime , Aldana-López Alejandro , Náfate-López Omar , Orozco Ricardo , Cordoba Gloria , Alvarado Rubén , Borges Guilherme
Published: January 2023

Objective. Report the prevalence of depression, resilience, and risk factors among healthcare workers (HCW) during Co­vid-19. Materials and methods. This is an observational cross-sectional study derived from the ongoing international, prospective multicentric study “The COVID-19 HEalth caRe wOrk­Ers Study” (HEROES). A convenience sample of 2 127 HCW was obtained from Chiapas and Jalisco between May 19th and July 24th 2020. Depression was assessed using the Patient Health Questionnaire, resilience with the Brief Resilience Scale and a Covid risk scale was developed. Model-adjusted prevalence ratios (PRs) and an additive interaction model were performed. Results. Moderate-severe depression was found in 16.6% of HCW. Those from Jalisco, physicians, in hospitals, with chronic illness and mental health history were more depressed. The interaction between resilience and risk showed that, compared to those with no risk and medium/high resilience, HCW at risk with medium/high resilience had a 2.38 PR for depression while those at risk and low resilience had a PR of 5.83. Conclusion. This evidence points the need to develop strategies to enhance resilience and reduce the risk in HCW.
Análisis de la presencia de trisomía 8 en las diferentes fases de leucemia mieloide crónica
Authors: González-Yebra Beatriz , Ruiz-Velázquez Francisco Arath , Herrerías-García Anaid , González Ana Lilia , Lara-Lona Elia , Muñoz-López Daniela , Amador-Medina Lauro Fabian
Published: January 2023

No disponible
National Institute of Public Health/School of Public Health of Mexico: contributions to social equity and knowledge-based public policies
Authors: Lazcano-Ponce Eduardo
Published: January 2023

The School of Public Health of Mexico (ESPM, in Spanish), was founded on March 23, 1922, several years after the creation of the first schools of public health in the United States of America (USA), such as Johns Hopkins in 1916 and those ofHarvard, Yale, and Columbia, among others. The Escuela de Salubridad, as the ESPM was initially called, was the first of its kind in Latin America and the fifth in the world; thus, it was responsible for providing the first public health degrees inMexico to medical health officers and other higher education diplomas in the fields of hygiene and public health. Several years after its own founding, in 1987, the ESPM co-founded the National Institute of Public Health (INSP, in Spanish) which to date continues to be the organization in which the ESPM is housed. Since the ESPM merged with the INSP, research and human resources training have been considered necessary processes for initiating and strengthening structural change in the field of health at the national and regional levels. As part ofits centennial, the ESPM is committed to the continued expansion of its future perspective through the restructuring of its academic programs; this is a process in which the instilling of values, a unified curriculum based on public health, a flexible educational model and social commitment are fundamental.
Key words: Public Health, Public Health School of Mexico, social equity and education.
Centennial of the School of Public Health of Mexico. Leadership, tradition and competitive advantage
Authors: Lazcano-Ponce Eduardo , Magaña-Valladares Laura
Published: January 2023

Not available
New routes to the future
Authors: Ruelas-Barajas Enrique
Published: January 2023

Not available
Development of an Artificial Neural Network Model and an Empirical Correlation for Predicting the Isobaric Instantaneous Thermal Expansion Coefficient of Crude Oils
Authors: Al-Marhoun Muhammad
Published: January 2023

The coefficient of isobaric thermal expansion of crude oils is essential in thermal methods of production and surface facilities design. The literature has no simple mathematical model to predict the instantaneous thermal expansion coefficient. Therefore, this study presents an artificial neural network (ANN) model and an empirical correlation for predicting crude oil's isobaric instantaneous thermal expansion coefficient. The input parameters for the ANN model and correlation are the usually measured parameters of reservoir temperature, solution gas-oil ratio, gas and oil-specific gravities, bubblepoint pressure, and pressure. The paper exclusively deals with thermal expansion for the Middle East crude oil samples. However, they should be valid for all types of crude oils with properties falling within the range of data used in this study. The statistical and graphical error analyses were used to check the performance and accuracy of the ANN model and correlation.
Self- and Graft-Supported Human Gingival Fibroblasts Derived Cell Sheets As A Potential Source of Periodontal Regeneration: In Vitro Evaluation
Authors: A.GamalElDin Ghada G , Gamal Ahmed Y , Moshy Sara El , El-Sayed Karim M. Fawzy
Published: January 2023

Cellular deficiency in periodontal and peri-implant diseases represents the major challenge in treatment outcomes. Cell sheet therapy is an approach by which cell-to-cell communication through endogenous matrix secretion offers a good modification to increase the reliability of traditional cell therapy. In this study, sandwiching the rapidly resorbable scaffold with gingival fibroblasts to produce cell sheet supported graft material will be tried to produce a sheet with adequate thickness and stiffness for more predictable clinical outcomes in soft tissue augmentation. The present study will be performed to investigate the physicochemical characteristics of the produced cell sheets with the primary outcome, which is cell sheet thickness, and secondary outcomes, which are the number of viable cells, laminin and fibronectin production, resistance to mechanical forces, and cell morphology following gingival fibroblast expansion with or without rapidly resorbable construct.
Tutorial on PARADISe: PARAFAC2-based Deconvolution and Identification System for processing GC–MS data
Authors: Quintanilla-Casas Beatriz , Bro Rasmus , Hinrich Jesper Løve , Davie-Martin Cleo L.
Published: January 2023

The present protocol provides general guidelines for users working with PARADISe, a deconvolution and identification system for processing GC-MS data. This tool allows users to perform untargeted analysis of large datasets efficiently and minimizes inter-user variability. The final output is a peak table, in excel format, containing the peak area and the purified spectrum for each resolved compound.
A sales strategy optimization model on online group buying in a fuzzy dual channel supply chain using a game theoretic approach
Authors: Heidarpoor Farnaz , Ghazanfari Mehdi , Jabalameli Mohammad Saeed , Jabbarzadeh Armin
Published: January 2023

Different factors affect customers' decisions on the selection of a service. Two of the essential factors are the price and the level of service provided by a seller to customers. The seller's credibility is also among the influential factors in selecting and buying a service that is reinforced by advertisements (offline advertisement or sales through an online group buying platform) and the provided service level. Accordingly, this study develops a fuzzy mathematical model to simultaneously determine price, service level, and advertisement level in a dual channel supply chain during two current and future courses according to the cooperative game between the seller and the platform. All parameters of the problem are determined as fuzzy variables. The seller can sell her/his service through individual sales strategy (offline) or mixed strategy, selling her/his service through the platform (online) and offline channels. The aim is to determine the optimal strategy for the seller when deciding to join the group buying platform, which is compared with the individual strategy. By considering the structures of group buying platforms, different refunding policies and revenue sharing policies are developed under six scenarios for the centralized model . The optimal solutions of the problem are then defined using the game theory approach and fuzzy sets theory for each scenario. Ultimately, a numerical example is provided to indicate the effectiveness of theoretical results of models and developing management insights. Besides, performed sensitivity analyses in this article also provide the effect of the change in essential parameters on seller decisions.
Automatic Adaptive Synchronization (A2S): A Demand-based Automatic Synchronization for Grid Connected Distribution Generators in Islanding Mode
Authors: C Alwin Vinifred , R Ramesh , S Dhandapani
Published: January 2023

For grid-connected islanded connection of microgrid, the synchronization is necessary, but the existing methods solve the problem with high harmonics in the signal. And also, the imbalanced voltage and rate of change of frequency at the microgrid are obtained by the sensor network or by synchronizing relays in many studies, which is an expensive technique. Hence to solve the problem, the paper introduced the automatic adaptive synchronization (A2S) scheme by using optimization and control techniques to synchronize the microgrid with the decentralized generators. The multiple decentralized generators serve the load through the microgrid, the voltage and phase are synchronized with the adaptive neuro-fuzzy inference system (ANFIS). The imbalance among them is sensed by the rain optimization algorithm (ROA). Thus the sensed changes are fed to the controller to provide gating signals accordingly to the cascaded H-bridge multi-level inverter with reduced harmonics. The distributed generator feeds the load through the 14km feeder line and synchronizes the three-phase voltage at 1.9ms with 2.28% distortion.
Sustainable Urban development: An evaluation of the impact of IoT on sustainable development and energy management in SMART cities
Authors: Shenkoya Temitayo
Published: January 2023

While there are many studies that focused on the technicality of the impact of the IoT on SMART cities, there is a paucity of extant literature that focus on clearly stating the impact of the integration of the IoT in SMART cities - to help policy makers, governments and civil society actors in the global south understand how this technology can be used to champion sustainable urban development, recognize the requirements for the adoption of the technology, grasp the institutional transformation needed, and determine the right policies that must be in place for the technology to succeed. This study bridged this gap by carrying out a systematic literature review with bibliometric analysis – using the PRISMA 2020 guideline - on the subject matter. Within this study 77 contributions were examined, and the results show that some of the benefits of IoT enabled SMART cities (IoTSMART Cities) are - green energy development, transmission, and management; the development of SMART grids that utilize green energy sources; an improvement in the performance of IoT enabled devices; a better integration of human – machine, machine – machine and human – human relationship; and the promotion of long-term sustainable development.
Recognition of Hand Gestures using Wavelet Packet Transform and Cascaded Feed Forward Neural Networks
Authors: S Mary Vasanthi , Jayasree T
Published: January 2023

This paper presents a noval framework that classifies finger movements automatically using Wavelet Transform and its derivatives by capturing statistical features from the discrete time Electromyogram (EMG) signals. In the suggested method, wavelet-based denoising is used to separate out the subject's EMG signals, and then Discrete Wavelet Transform (DWT) and Wavelet Packet Transform are used to decompose the signals and extract their key characteristics (WPT). The derivatives of the feature sets are employed to analyse the correlation among them. This method is motivated by the surveillance that there exists a distinctive correlation between the different features of the samples of the signals extracted at various frequency levels. Experimentally, it was perceived that this correlation varies from signal to signal. Both Feed forward and Cascaded Feed forward Artificial Neural Networks (ANN) are used for classification. Experiments show that the proposed method significantly improves the classification rate. The performance of the suggested wavelet-based features and their derivatives in combination with ANN and trained with the Levenberg-Marquardt algorithm was evaluated by comparing the simulation results for various sets of features. Comparing the new method benefits to earlier traditional methods in terms of classification performance helped to further highlight their advantages. These experimental findings demonstrate that the suggested approach performs admirably in classifying finger movements based on EMG signal patterns. The suggested methodology also helps clinicians increase the reliability of myoelectric pattern recognition.
RVFScan predicts virulence factor genes and hypervirulence of the clinical metagenome
Authors: Gu Bing , Jiang Yue , Hu Xuejiao , Fan Shu , Liu Weijiang , Chen Jingjing , Wang Liang , Deng Qianyun , Yang Jing , Yang Aimei , Lou Zheng , Guan Yuanlin , Xia Han
Published: January 2023

Bacterial pathogenicity often involves various virulence factors (VFs). Detecting virulence factor genes (VFGs) is critical for the precise treatment and prognostic management of bacterial infections. However, there is a lack of rapid and accurate methods for VFG identification from the metagenomes of clinical samples. We developed RVFScan (Read-based Virulence Factors’ Scanner), a novel user-friendly online tool that integrates a comprehensive VFG database with corresponding similarity matrix-based criteria for VFG prediction and annotation using metagenomic data without assembly. RVFScan outperformed previous assembly-based and read-based VFG predictors with 97% sensitivity, 98% specificity and 98% accuracy. To investigate the application of RVFScan, we performed the first large-scale analysis of 2425 clinical metagenomic datasets, obtaining species-specific VFG profiles and VF-phenotype associations for 24 important pathogens. By combining genomic comparisons and network analysis, we identified 53 VFGs with significantly higher abundances in hypervirulent Klebsiella pneumoniae (hvKp) than in classical K. pneumoniae (cKp). Furthermore, a cohort of 1256 samples suspected of Klebsiella pneumoniae infection demonstrated that RVFScan could accurately identify hvKp (90% sensitivity, 100% specificity, and 98.73% accuracy; Cohen’s kappa, 0.94; 90% of hvKp samples were consistent with clinical diagnosis). RVFScan could be applied to assembly free metagenomic reads to detect VFGs in low-biomass and high-complexity clinical samples, enabling the rapid identification and symptomatic treatment of hvKp infection and could be applied to other hypervirulent pathogens.
Injuries after cardiopulmonary resuscitation in the pre-hospital and hospital care in two regions of the Czech Republic: retrospective observational cohort study
Authors: Stanislav POPELA , Martin DOBIAS , OLECKA Ivana , Tomas VOJTÍŠEK , Michal PLUHAR , David PERAN
Published: January 2023

Background
Chest compressions applied manually or with mechanical devices can encounter various types of injuries. The aim of this study is to analyse the corelation between the way the chest compressions were applied and the types of injury in deceased patients who underwent CPR for sudden cardiac arrest of non-traumatic aetiology. Study is reported as per STROBE guidelines.
Methods
This is a retrospective observational cohort study from two geographical regions of the Czech Republic. Adult patients (>18 years old) with sudden cardiac arrest of non-trauma aetiology resuscitated by the emergency medical services were included.
The cohorts were divided based on the way the chest compressions were provided – manual compressions, compressions provided by mechanical device, and compressions provided manually with the use of cardio pump. The variables used were injuries found during the autopsy.
Results
The research set of 113 cases of non-traumatic adult sudden cardiac arrests consisted of 75 men and 38 women. Average time of resuscitation was reported as 32.9 minutes. Manual chest compressions were performed in 46 (40.35%) cases, manual chest compressions using cardio pump in 27 (23.68%) cases, and mechanical chest compressions in 40 (35.08%) cases.
Conclusions
The use of cardio pump or mechanical chest compressions relates to more left side serial rib fractures and skin injuries, than manual chest compressions in the group of deceased adults who underwent resuscitation of non-trauma origin.
Effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery: A Double-Blind, Randomized Trial
Authors: He Fang , Lu Yizhi , Mao Qi , Zhou Lifang , Chen Yanhua , Xie Yubo
Published: January 2023

Aim:To investigate the effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery with cardiopulmonary bypass (CPB).Methods:A total of 180 patients undergoing elective heart valve surgery with CPB were randomly divided into four groups: 45 in group P (intravenous penehyclidine hydrochloride 0.02 mg/kg 10 min before anesthesia induction and at the beginning of CPB, total 0.04 mg/kg); 43 in group D (dexmedetomidine 0.5 μg/kg/h after induction of anesthesia until the end of anesthesia); 44 in group PD ( penehyclidine hydrochloride 0.04 mg/kg combined with dexmedetomidine 0.5 μg/kg/h intravenously during anesthesia); and 43 in group C (same amount of normal saline 10 min before and after anesthesia induction, to the end of anesthesia, and at the beginning of CPB). The main outcomes were the incidence and severity of postoperative pulmonary complications (PPCs). The secondary outcomes were: (1) extubation time, length of stay in intensive care, and postoperative hospital stay, and adverse events; and (2) pulmonary function evaluation indexes (oxygenation index and respiratory index) and plasma inflammatory factor concentrations (tumor necrosis factor-α, interleukin-6, C-reactive protein and procalcitonin) during the perioperative period.Results:The incidence of PPCs in groups P, D and PD after CPB was lower than that in group C (P< 0.05), and the incidence in group PD was significantly lower than that in groups P and D (P< 0.05). The scores for PPCs in groups P, D and PD were lower than those in group C (P< 0.05).Conclusion:Combined use of penehyclidine hydrochloride and dexmedetomidine during anesthesia reduced the occurrence of postoperative pulmonary dysfunction, and improved the prognosis of patients undergoing heart valve surgery with CPB.Trial registration:The trial was registered in the Chinese Clinical Trial Registry on 3/11/2020 (Registration No.: ChiCTR2000039610).
Damage Evaluation of Steel Beam-to-column Connections Based on Flange Strain History
Authors: Jiao Yu , Tenderan Randy , Yamada Satoshi
Published: January 2023

The plastic deformation capacity of beam-to-column connections strongly affects the seismic capacity of steel moment frames in seismic design. Ductile fractures that occur after adequate plastic deformation and crack propagation is one of the most typical steel component failure modes during earthquakes. A key index that affects the fractures of materials is the strain amplitude at the critical cross-section. For most structural steels, the strain-life relationship can be expressed using a Manson–Coffin-type equation. The current study proves whether there is a similar Manson–Coffin relationship between the average flange strain amplitude at the critical cross-section and the number of loading cycles until fracture. Shop welded beam-to-column connections made of 400 N/mm2 class structural steel with conventional or improved types of weld access holes are discussed in this study. When these connections are subjected to cyclic loadings, ductile cracks initiated at the toes of the weld access holes propagate during loading, leading to the eventual fractures of the connections. Moreover, cyclic in-plane beam analysis is conducted using an experimental database of 10 beam-to-column connections that are loaded until ductile fractures occur to obtain the strain histories at the beam-end flanges. Based on the strain histories, it is found that, similar to the material level, the Manson-Coffin relationship between the average flange strain amplitude at the critical cross-section and the number of loading cycles until fracture is confirmed on the component level. The Manson–Coffin-type strain-life relationship equations are obtained for these connections with two types of weld access holes. In addition, the results of previous beam-to-column connections loaded under variable amplitudes were studied. To expand the size of the database, experiments were conducted on two beam-to-column connections corresponding to random loading histories. The accuracy of the proposed Manson–Coffin relationships is verified with the experimental results under random loading histories. The current study provides a possible solution for the damage evaluation of steel beam-to-column connections based on strain amplitudes through analysis and a limited number of experiments.
Single-organ Pulmonary Metastasis is a favorable prognostic factor in Metastatic Colorectal Cancer Patients Treated with FOLFIRI and Vascular Endothelial Growth Factor Inhibitors
Authors: Fukuda Koshiro , Osumi Hiroki , Yoshino Koichiro , Nakayama Izuma , Fukuoka Shota , Ogura Mariko , Wakatsuki Takeru , Ooki Akira , Takahari Daisuke , Chin Keisho , Yamaguchi Kensei , Shinozaki Eiji
Published: January 2023

Background: Few studies have focused on the impact of single-organ pulmonary metastases on progression-free survival and overall survival in patients with metastatic colorectal cancer. Recognizing differences in prognosis and chemotherapeutic efficacy based on metastasized organs may help in optimizing treatment strategies. The exploratory study was conducted to evaluate the comparative clinical outcomes and prognoses of patients with metastatic colorectal cancer presenting with single-organ pulmonary metastases and treated with folinic acid, 5-fluorouracil, irinotecan, and vascular endothelial growth factor inhibitors as second-line chemotherapy.
Methods: This retrospective study included 289 patients with metastatic colorectal cancer treated with second-line folinic acid, 5-fluorouracil, irinotecan, and vascular endothelial growth factorinhibitors. The response rate, disease control rate, progression-free survival, and overall survival were assessed in the participants.
Results: Among the 289 patients enrolled, 26 (9.0%) had single-organ pulmonary metastasis with left-sided primary locations, lower levels of tumor markers at the initiation point of chemotherapy, a significantly higher disease control rate (96.2% vs. 76.7%, P = .02), and a longer progression-free survival (median 29.6 months vs. 6.1 months, P < .001) and overall survival (median 41.1 months vs. 18.7 months, P < .001) than patients with other forms of metastatic colorectal cancer. Multivariate analysis showed that single-organ pulmonary metastasis was an independent predictor of longer progression-free survival (hazard ratio 0.37, P = .002) and overall survival (hazard ratio 0.23, P < .001).
Conclusion: Single-organ pulmonary metastasis was a strong predictor of progression-free survival and overall survival in patients with metastatic colorectal cancer treated with folinic acid, 5-fluorouracil, irinotecan, and vascular endothelial growth factor inhibitors as second-line chemotherapy; this provides preliminary evidence for medical guidelines and clinical decision-making on novel therapeutic strategies for these patients.
Paneth cells as the origin of intestinal cancer in the context of inflammation
Authors: Fodde Riccardo , Verhagen Mathijs , Joosten Rosalie , Schmitt Mark , Sacchetti Andrea , Choi Jiahn , Välimäki Niko , Aaltonen Lauri , Augenlicht Leonard
Published: January 2023

Paneth cells (PCs), responsible for the secretion of antimicrobial peptides in the small intestine and for niche support to Lgr5+ crypt-base columnar stem cells (CBCs), have been shown to respond to inflammation by dedifferentiating into stem-like cells in order to sustain a regenerative response1,2. Therefore, PCs may represent the cells-of-origin of intestinal cancer in the context of inflammation.
To test this hypothesis, we targeted Apc, Kras, and Tp53 mutations in Paneth cells by Cre-Lox technology and modelled inflammation by dextran sodium sulfate (DSS) administration. PC-specific loss of Apc resulted in multiple small intestinal tumors, whereas Kras or Tp53 mutations did not. Compound Apc and Kras mutations in PCs resulted in a striking increase in tumor multiplicity even in the absence of the inflammatory insult. By combining scRNAseq with lineage tracing to capture the conversion of PCs into bona fide tumor cells, we show that they progress through a “revival stem cell” (RSC) state characterized by high Clusterin (Clu) expression and Yap1 signaling, reminiscent of what has been previously observed upon irradiation of the mouse digestive tract3. Accordingly, comparison of PC- and Lgr5-derived murine intestinal tumors revealed differences related to Wnt signaling and inflammatory pathways which match the dichotomy of CBCs and injury-induced RSCs4 between human sporadic colon cancers and those arising in the context of inflammatory bowel diseases. Last, we show that western-style dietary habits, known to trigger a low-grade inflammation throughout the intestinal tract, underlie the analogous de-differentiation of Paneth cells and their acquisition of stem-like features.
Taken together, our results show that intestinal cancer arises in the context of inflammation through the dedifferentiation of committed secretory lineages such as Paneth cells and the activation of the revival stem cell state. As such, a true quiescent stem cell identity may be hidden in fully committed and post-mitotic lineages which, upon inflammation, support the regenerative response by re-entering the cell cycle and dedifferentiating into RSCs. The chronic nature of the tissue insult in inflammatory bowel diseases and even in the context of western-style dietary habits is likely to result in the expansion of cell targets for tumor initiation and progression.
WITHDRAWN: The impact of green transformational leadership and green HRM on green innovation and environmental performance
Authors: Usprech Jory , Palmert Graham
Published: January 2023

We used the resource-based view and the ability-motivation-opportunity theory to analyze the connections between green transformational leadership, green innovation, and environmental performance as they relate to green human resource management. We gathered tetradic data from 309 SMEs in the manufacturing sector using a questionnaire (SMEs). In this investigation, we tested hypotheses using structural equation modeling (SEM) with a covariance focus. According to the findings, the relationship between green transformational leadership and green innovation is mediated by green human resource management techniques. In addition, we discovered that green HRM affects a company's environmental performance in a roundabout way through green innovation. Overall, our study's results back up all hypotheses of direct and indirect impacts and have various theoretical and practical consequences. Finally, our research makes a significant theoretical contribution by indicating that the HRM-performance relationship depends not on the additive effect of green transformational leadership and green innovation as antecedent and mediator, respectively, nor on their interactive effect, but on a mix of both combinational forms (i.e., additive and interactive) to affect firm environmental performance. Overall, our research adds to the literature by expanding on the idea that leadership has a significant impact on HRM practices, which in turn predicts green innovation in the workplace.
Brief Preoperative Frailty Screening Predicts Adverse Postoperative Outcomes in Elderly Patients with Radical Esophageal Cancer Surgery
Authors: Hao Xinyu , Guo Yongxin , Xu Ziyao , Liu Jingjing , Tian Jingyang , Cao Fuyang , Song Yanping , Liu Yanhong , Fu Qiang , Cao Jiangbei , Mi Weidong , Li Tong
Published: January 2023

Background
Frailty is increasingly becoming a powerful prognostic factor for cancer patients after surgery. The purpose of this study was to explore the prognostic value of 5-modified frailty index (mFI-5) in postoperative mortality and major morbidity in patients with esophageal cancer over 65 years of age.
Methods
Data comes from the largest database of esophageal cancer patients in China. A total of 699 patients over 65 years old who underwent primary esophagectomy from January 1, 2014 to January 31, 2017. mFI-5 variables include hypertension, type Ⅱ diabetes, congestive heart failure, chronic obstructive pulmonary disease, and independent functional status. 1 point is assigned to each variable. Patients were divided into 3 groups based on their mFI-5: frail group (mFI-5, 2–5), prefrail group (mFI-5, 1) and robust group (mFI-5, 0). The primary outcome was 30-day mortality. Secondary outcomes were postoperative pneumonia and postoperative delirium.
Results
A total of 699 patients were included in the cohort study. Frailty group had the highest incidence of postoperative delirium (frailty: 22.5% vs. prefrailty : 14.7% vs. robust : 2.9%; p < 0.001), postoperative pneumonia (frailty : 13.3% vs. prefrailty : 9.8% vs. robust : 3.8%; p < 0.001), and 30-day mortality (frailty: 5.8% vs. prefrailty : 1.6% vs. robust: 1.2%; p < 0.001). Multivariate analysis showed that frailty was associated with a significantly increased risk of postoperative delirium (aOR, 6.82; 95% confidence interval (CI), 3.12–14.89; p < 0.001), postoperative pneumonia (aOR, 4.12; 95%CI, 2.52–5.72; p < 0.001) and 30-day mortality (aOR, 14.30; 95%CI, 4.87–42.03; p < 0.001).
Conclusions
Frailty, as determined by mFI-5, is associated with increased odds of postoperative delirium, postoperative pneumonia, and 30-day mortality in patients undergoing radical esophagectomy.
Growth of a red alga species (Vertebrata lanosa) in lab culture
Authors: Petride Newt , Fredriksen Stein
Published: January 2023

Vertebrata lanosa is an intertidal red algal species that grows epiphytically on Ascophyllum nodosum, a brown fucoid alga. V. lanosa received culinary interest in the recent years due to its truffle-like taste and it is currently only harvested from natural populations. This study has focused on the growth of the species in lab cultures and investigated the temperature and salinity leading to higher specific growth rate. V. lanosa showed higher growth rate in 10 oC and 30‰. Overall, the study identified optimal temperature and salinity conditions for indoor controlled cultivation of the species and proved that Vertebrata lanosa can be cultivated in absence of its host, A. nodosum. Furthermore, a complete life cycle of V. lanosa has been carried out in culture where all life history phases and stages were observed. Though, to move from experimental culture to a larger scale production, further research is needed both on the cultivation of the species and the biochemical interactions with its host. Acknowledgements
Assessment the impact of Anthropogenic activities on sediment physico-chemical characteristics of Owalla Reservoir, Osun State, Southwest, Nigeria
Authors: Aduwo Idowu , Adesakin Taiwo , Oyewale Abayomi , Adeniyi Funso
Published: January 2023

The study assessed the physico-chemical characteristics of sediments from Owella reservoir in Osun State, Nigeria with the primary aim of creating a baseline information in aspect of limnology and also to further assess influenced by anthropogenic activities as well as characteristics that were affected mostly by natural sources in the water body. Twenty sampling stations were established along the reservoir representing its three different sections and two zones for a period of two years. On the average, the reservoir sediment was mostly sand, clayey-sand in texture, acidic in chemical reaction, low in nutrients and moderate in organic matter. Although, nutrients were identified to be mostly of anthropogenic origin, while alkali metals and alkaline earth metals were from both anthropogenic and natural sources. The overall order of dominance of the exchangeable cations was: Mg2+ > Ca2+ > H+ > Al3+ > K+ >Na+ and anions in the order PO34- > SO42− > NO3−> Cl−. Significantly difference (p < 0.05) were observed in the physico-chemical characteristics of the sediment across the two zones (littoral and open water) of the reservoir and horizontal variation along the three basin sections (upstream, mid-basin and downstream) and over the two seasons of the year were mostly not significant (p > 0.05). The overall mean values obtained for particle size distribution along the reservoir were in the following order: sand (7.31%) > Silt (43%) > clay (57%). Surface run-offs are major contaminant in Nigeria waterbodies and through geochemical weathering of the top soils. The results showed low concentration of cations, anions and nutrients compound in the sediment of Owella reservoir which suggests low influence of anthropogenic activities on the sediment quality.
The use of Dual Mobility cups in primary Total Hip Arthroplasty: a bicentric, retrospective study of 196 implants
Authors: Ciatti Corrado , Quattrini Fabrizio , Caggiari Gianfilippo , Doria Carlo , Fernàndez Ramón Vallenilla , Marquez Carlos Eduardo , Mohtar Shamira , Jaén Ruben , Monasterios Andrés Mauricio , Maniscalco Pietro
Published: January 2023

Background
Dual Mobility is based on two concentric joints: a head within a retentive polyethylene liner, which moves freely inside the acetabular cup. This paper aims to present our experience with the use of dual mobility in primary hip replacement, evaluating the patient’s outcome after surgery.
Methods
We conducted a retrospective bi-centre study, including all patients operated with a dual mobility hip replacement at “Centro Medico de Caracas” (Caracas, Venezuela) and “Guglielmo da Saliceto Hospital” (Piacenza, Italy), between August 2014 and August 2020 (6 years). Dualis® dual mobility cementless cup was used in all surgeries, coupled with different stems. Outcome assessment after hip replacements was determined with the Harris Hip Score at 3 months post surgery., then we registered any complications in the first two postoperative years.
Results
The total cohort was composed of 196 THAs: 35.4% male, 64.6% female (64.6%), mean age 63.6 years. We used 3 different stems: Korus (Gruppo Bioimpianti S.r.l.) (78.1%), Fin (Gruppo Bioimpianti S.r.l.) (3.1%) and Corail (DePuy Synthes) (18.9%). The femoral head was composed of ceramic (93.9%) or metal (6.1%); the size was always 28 mm. The average Harris Hip Score was 34.3 ± 15.8 (min 4 - max 69) preoperative, and 91.2 ± 6.7 (min 61 - max 100) at 3 months follow-up. The HHS grading was “Poor” in 1.0% cases, “Fair” in 6.1% cases, “Good” in 27.0% cases and “Excellent” in 65.8% cases. The outcome was significantly better in young patients: mean HHS of the 98 younger patients is 95.9 ± 2.8, while that of the 98 older patients is 86.5 ± 6.2 (p value < 0.001). We registered an overall dislocation rate of 0%, while we reported 8 revisions (4.1%), due to periprosthetic fracture (4), aseptic loosening (1, infection (1), component breakage (1) and pain (1). The coupling Dualis-Korus reported a failure rate of 3.3% (5/153), Dualis-Fin 16.7% (1/6) while Dualis-Corail 5.4% (2/37).
Conclusion
The dual mobility system is an effective solution within primary hip replacement: it reduces wear and loosening forces, increasing joint range and prosthesis stability, with a very low incidence of dislocation. In younger patients, and arthritic ones, even the best results can be expected.
How the resistivity acts near a coronal null point
Authors: Sabri Somaiyeh , Poedts Stefaan
Published: January 2023

We investigate the effect of magnetic resistivity on the propagation and evolution of magnetoacoustic waves and plasma in the neighborhood of a magnetic null-point. Various values for the magnetic resistivity associated with solar coronal conditions have been taken under consideration in the context of magnetohydrodynamics by implementing the PLUTO code. The magnetic diffusivity controls the current sheet and spikes together with their direction. The same goes for the direction of the induced flows as the speed of the induced flows is proportional with the magnetic diffusivity. This is while the acceleration of the flows is inversely proportional with the magnetic diffusivity. The high values of magnetic diffusivity contribute towards the collapse of magnetic fields while reversing the direction of the induced flows. Therefore, null collapse is a class of MHD implosion that null is the center of converging magnetic flux and plasma compression and refraction happen due to the converging and diverging flow driven by Lorentz force. The implosion continues until some limiting events can develop sufficiently to stop this focusing. The current density at the magnetic null-point is dependent on the magnetic diffusivity that could be related to the high gradient of the magnetic field around the null point. A relatively high value of the magnetic diffusivity causes the current density to possess a positive value while it possesses a negative value for relatively low values. The opposite value for the polarity of the current density is associated with the opposite direction of the magnetic null-point collapse. Besides, it is found that at initial timescales prior to the creation of plasmoids, the plasma density is small with high current density accumulation at small magnetic diffusivity values which is in accordance with previous analytic results. But, throughout the entire simulation time the plasma density becomes significant in a sense that the current density would be proportional to the magnetic diffusivity.
Rapid development and mass production of SARS-CoV-2 neutralizing Chicken egg yolk antibodies with protective efficacy in hamsters
Authors: Zhao kai , zhao binan , Peng Haoran , Zhang Yanjing , Zhang Jie , Kong Desheng , Cao Sai , Li Yan , Yang Dan , Sun Chuanwen , Pu Xinyi , Zhao Ping , Xu Yan , Xie Liangzhi
Published: January 2023

Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and application of therapeutics remain low in developing countries. Rapid and low cost mass production of antiviral IgY antibodies could be an attractive alternative or complementary option for vaccine and therapeutic development. In this article, we rapidly produced SARS-CoV-2 antigens, immunized hens and purified IgY antibodies in 2 months after the SARS-CoV-2 gene sequence became public. We further demonstrated that the IgY antibodies competitively block RBD binding to ACE2, neutralize authentic SARS-CoV-2 virus and effectively protect hamsters from SARS-CoV-2 challenge by preventing weight loss and lung pathology, representing the first comprehensive study with IgY antibodies. The process of mass production can be easily implemented in most developing countries and hence could become a new vital option in our toolbox for combating viral pandemics. This study could stimulate further studies, optimization and potential applications of IgY antibodies as therapeutics and prophylactics for human and animals.
Clinical outcomes of the anatomical double-bundle anterior cruciate ligament reconstruction compared with the single-bundle technique: A Systematic Review and Meta-analysis.
Authors: Li Renbin
Published: January 2023

Objective This meta-analysis aims to evaluate clinical outcomes of arthroscopic single-bundle (SB) versus anatomical double-bundle (ADB) anterior cruciate ligament (ACL) reconstruction in ACL-injured adults. With the synthesis of all accessible randomized controlled trials (RCTs), it was hypothesized that the ADB method is superior to the SB technique. Methods The PRISMA checklist’s instructions were followed. To identify RCTs that compared the SB and ADB treatments, a thorough literature search was conducted through electronic resources including PubMed, Embase, Cochrane library, and Web of Science. The methodological quality of each included study was assessed by two independent authors by the Cochrane Collaboration’s risk of bias tool. The ADB techniques of all included studies were screened by the AARSC to determine the eligibility of operation. Nine clinical outcomes were extracted to compare the two techniques. We used the Review Manager 5.3 to make this analysis. Results This meta-analysis included 20 randomized controlled studies comparing outcomes between ADB with SB techniques in ACL reconstruction. After a minimum follow-up of 12 months, the ADB technique was similar to SB technique in subjective clinical outcomes, including IKDC subjective score, Lysholm score, Tegner activity score. Similar results were also found in the objective outcomes, such as IKDC objective grade, Pivot-shift test, Lachman test, Side-to-side difference, and OA change. Conclusion In general, when the ACL reconstruction approach meets the minimal total AARSC score of eight, the ADB and SB techniques can result in similar subjective results and knee laxity. Level of evidence I.
Evaluation of the effect and mechanism of artemether against Toxoplasma gondii
Authors: Xu Qiong , Duan Yin-Yan , Pan Ming , Jin Qi-Wang , Tao Jian-Ping , Huang Si-Yang
Published: January 2023

This study aimed to investigate compounds that has anti-Toxoplasma gondii with the possible advantage of limiting drug resistance. Artemether has potential anti-T. gondii activity, however the detail information is not clear. To evaluate the Specific effect and potential mechanism, in this study, the cytotoxicity of artemether was Firstly evaluated using MTT assay. Secondly, the anti-T. gondii activities was determined using plaque assay, and then the invasion and intracellular proliferation were evaluated. Finally, the mitochondrial membrane potential and reactive oxygen species (ROS) of T. gondii were detected by the JC-1 probe and automatic microplate reader. The safe concentration of artemether is below 7.042 mM on HFF cells, and artemether exhibited good anti-T. gondii activity with the IC50 = 0.905 mM, it can inhibit T. gondii intracellular proliferation by decreasing T. gondii mitochondrial membrane integrity and increasing ROS production.
Multiple myeloma extramedullary lesions presenting withmultiple soft tissue masses in the neck, chest, abdomen, and back: a case report
Authors: shan jing , wang shuangyan , kang boyu , lv sumei
Published: January 2023

Background:
Multiple myeloma (MM) extramedullary disease (EMD) is an invasive growth of-clonal plasma cells that, is characterized by myeloma cells escaping from the bone marrow microenvironment, entering the blood circulation and infiltrating and growing in other organs. Soft-tissue involvement was associated with significantly shorter progression-free survival and overall survival, with a poor prognosis and a median survival of 8.5 months. Among the sites involved in extramedullary lesions, the abdomen and back are rare. The prognosis of soft tissue masses located in extramedullary organs is the worst, and the treatment of soft tissue masses with enlargement of extramedullary lesions is still difficult because the poor effects of radio-chemotherapy.
Case Presentation:
We present an MM patient who experienced multiple skeletal-related events with EMD in the neck, chest, abdomen, and back after four surgical interventions, multiple cycles of chemotherapy and autologous peripheral blood stem cell transplantation, and surgical resection.
Conclusions:
MM with a large extramedullary plasma cell tumour often is not responsive to chemotherapy and radiotherapy. For continuously growing masses, surgical resection is recommended to reduce the tumour load, relieve pain, and relieve secondary vascular and nerve compression.
Barrier Lyapunov function-based adaptive neural control for hypersonic vehicle with full state constraints
Authors: Zhao He-wei
Published: January 2023

In this paper, an adaptive neural backstepping control method based on barrier Lyapunov function is proposed for hypersonic vehicle considering full state constraints. The longitudinal dynamic of hypersonic vehicle can be divided into two subsystems, i.e., altitude subsystem and velocity subsystem and the controllers are designed with backstepping method, respectively. In the designing process, the radial basis function neural networks are used to approximate the unknown nonlinear functions of longitudinal dynamic, therefore, the accuracy requirement of hypersonic vehicle model is largely reduced. In order to handle the explosion of complexity issues occurring in the backstepping method, a tracking differentiator is introduced to calculate the differential of virtual control law. The barrier Lyapunov function is constructed to overcome the full system dynamic state constraints and an auxiliary system is designed for overcome the input state saturation issue. The stability is carried out based on Lyapunov theory, and the signals of closed-loop system established are uniformly ultimately bounded. The simulation results show that the controller designed for hypersonic vehicle can guarantee the good tracking performance.