bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of the gut bacteria of the greater wax moth
Authors: Betancourt Oriana , Araneda Ximena , Pesenti Héctor , Anabalón Leonardo
Published: December 2022

Throughout the world, the use of industrial polymers derived from fossil fuels is practically inevitable because they have such a wide range of applications; however, the environmental problems arising from this practice have led to a search for alternatives which will allow their use to be reduced, as well as strategies for their control by degradation using biorganic active agents. Insects have been a focus of special interest, as some species consume plastics and may serve to biodegrade them through the action of bacteria in their digestive tracts. In this context, the object of the present study was to characterise bacteria present in the intestine of wax moth larvae (Galleria mellonella). Thirty larvae were subjected to a diet based on polystyrene foam and thirty larvae in natural diet for 7 days. Gastrointestinal tracts were extracted and PCR was run. The results showed the presence of bacterial cells of Carnobacterium maltaromaticum, Brevibacterium sandarakinum, Pseudomonas psychrophila, Pseudomonas sp., Providence sp., Corynebacterium sp. However, the real action of these groups of bacteria in the effective degradation of polymers must be verified.
Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology
Authors: Nasonov E. L. , Ananyeva L. P. , Avdeev S. N.
Published: December 2022

Rheumatoid arthritis (RA) is an immune-mediated rheumatic disease (IMRDs) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. A particularly important place among the systemic manifestations of RA is occupied by interstitial lung diseases (ILD) – the most severe form of pulmonary pathology in RA, defined as RA-ILD, which is pathogenetically associated with risk factors (smoking, etc.) and autoimmune mechanisms underlying RA. RA-ILD is a subtype of RA characterized by a severe course and a poor prognosis и неблагоприятным прогнозом. The review presents new data regarding risk factors and biomarkers for RA-ILD; modern diagnostic capabilities based on the use of functional lung tests, high-resolution computed tomography, ultrasound examination of the lungs. Particular attention is paid to the efficacy and safety of pharmacotherapy, including methotrexate, biologics, JAK inhibitors, and antifibrotic therapy. An algorithm for the pharmacotherapy of RA-ILD has been proposed.
Manifestations of the gastrointestinal tract in systemic rheumatic diseases: A narrative review
Authors: Moroz E. V. , Popkova T. V. , Moroz A. E.
Published: December 2022

Gastrointestinal disorders are important place among the visceral manifestations of systemic autoimmune and immunoinflammatory rheumatic diseases (RD). Pathology of the esophagus, stomach, small and large intestine can vary from moderate functional disorders to the development of severe chronic inflammation with metaplasia and dysplasia of the mucous membrane, the formation of multiple erosions, hemorrhages and deep ulcers. Complications of gastrointestinal pathology in RD, such as bleeding, perforations and strictures, can cause death. This review examines the main clinical manifestations, possibilities of diagnosis and treatment of gastrointestinal lesions in systemic scleroderma, idiopathic inflammatory myopathies, systemic vasculitis, Sjogren’s syndrome and disease, as well as systemic lupus erythematosus.
Trabecular bone score in rheumatic disease
Authors: Kozyreva M. V. , Nikitinskaya O. A. , Toroptsova N. V.
Published: December 2022

Patients with rheumatic diseases (RD) are at high risk of osteoporosis (OP) and osteoporotic fractures. The Trabecular bone score (TBS) is a relatively novel method of assessing bone quality, which independently predicts fracture risk regardless of bone mineral density (BMD). A lower TBS in patients with RD compared to controls is shown in most studies concerning TBS and RD. The data obtained indicate that TBS predicts fractures better in RD, especially in patients receiving glucocorticoids, than BMD or the FRAX algorithm. TBS degradation has been associated with disease activity in ankylosing spondylitis, systemic sclerosis, and rheumatoid arthritis in a few studies. However, there is little data in the literature on the effect of rheumatic disease therapy and OP treatment in patients with RD on predictive ability of TBS for incident fracture.
Comparative pharmacoeconomic effectiveness of interleukin-17 inhibitors for the treatment of ankylosing spondylitis
Authors: Dubinina T. V. , Gaydukova I. Z. , Sableva N. А. , Sapozhnikov K. V. , Sokolova V. D. , Tolkacheva D. G.
Published: December 2022

Objective – to compare the clinical efficacy and cost-effectiveness of IL-17 inhibitors (SEC, IXE, NTK) in the treatment of adult patients with ankylosing spondylitis (AS) in the healthcare system of the Russian Federation.Material and methods. The study is a sub-analysis of a previously published systematic review and network meta-analysis of the comparative efficacy of biologics in adult patients with AS in the Russian Federation. NNT values were calculated for BASDAI 50 and ASAS 20/40 after 16 weeks of therapy for all studied drugs. CpR was estimated for each biologic after 16 weeks and one year of therapy. Additionally, we carried out an assessment of the financial burden of the most cost-effective strategies for the treatment of AS.Results. The use of NTK is characterized by an average of no more than three patients needed to treat to achieve one ASAS 20/40 or BASDAI 50 response, while on IXE and SEC – no more than 4–5 patients need to be treated, depending on the estimated effectiveness criterion. According to CpR estimate, NTK is the most cost-effective IL-17 inhibitor for the treatment of AS, both after 16 weeks and after one year of therapy.Conclusion. The obtained results make it possible to compare the effectiveness of IL-17 inhibitors from a clinical and economic points of view and can be used both in decision making process of treatment strategies for individual patients, and at the population level – when deciding on the reimbursement of drugs
The use of tenoxicam in active axial spondyloarthritis – focus on efficacy and safety
Authors: Rebrov A. P. , Nikitina N. M. , Magdeeva N. А. , Bogdalova L. R.
Published: December 2022

Purpose of the study – to study the efficacy and safety of tenoxicam (Texared®) in patients with active axial spondyloarthritis.Material and methods. The study included 35 patients with active axial spondyloarthritis with BASDAI≥4.0. Patients were given continuous oral tenoxicam (Texared®, Dr. Reddy’s Laboratories) at a dosage of 20 mg/day. Subsequently, 5 patients were excluded from the study due to discontinuation of the drug after 5–10 days of administration. 30 patients were included in the final analysis. Initially and after 30 days, to assess the severity of pain and stiffness, activity, patients filled out questionnaires in electronic form using Google forms, a general assessment of pain in the lower back and the intensity of night pain by the patient, subjective sleep characteristics were carried out. The doctor calculated the BASDAI, ASDAS-CRP, BASMI indices, and evaluated the activity according to the doctor’s opinion. The baseline blood pressure level was determined, and a patient diary was issued for ambulatory blood pressure measurement in the morning/evening for 30 days. After 30 days, the patient’s ambulatory blood pressure control was assessed. At baseline and after 30 days, biochemical blood parameters were studied, including a complete blood and urine test.Results and conclusion. In patients with axial spondyloarthritis with high and very high activity, a positive effect of tenoxicam (Texared®) therapy on disease activity was noted. The effect of Texared® develops with regular use already during the first 2 weeks, and after 4 weeks there is a clear decrease in the severity of pain in the lower back, a decrease in the duration of morning stiffness. The drug is well tolerated, has a favorable safety profile, no serious adverse events and few side effects that do not require discontinuation of therapy.
Prognostic factors associated with achieving minimal disease activity in early psoriatic arthritis patients treated according to “treat-to-target” st rategy within 12 months
Authors: Loginova E. Yu. , Korotaeva T. V. , Gubar E. E. , Glukhova S. I.
Published: December 2022

Background. The goal of “treat-to-target” strategy (T2T) in psoriatic arthritis (PsA) is attaining remission or minimal disease activity (MDA). The benefits of T2T are shown recently in the study TICOPA and REMARCA. But prognostic factors for achievement MDA in PsA patients (pts) at the early-stage hasn’t been studied yet.Objective – to determine the prognostic factors associated with achievement of minimal disease activity within 12 months (mo) of treatment according to T2T strategy in early psoriatic arthritis patients.Methods. 77 pts (M/F=36/41) with early PsA fulfilling the CASPAR criteria were included. Mean age 36.9±10.45 years, PsA duration 11.1±10.0 mo, psoriasis duration 82.8±92.1 mo. At baseline (BL) and at 12 mo of therapy PsA activity by tender joins count (TJC) out of 68; swelling joints count (SJC) out of 66; pain; patient global assessment disease activity (PGA) using visual analogue scale; CRP; dactylitis, enthesitis by LEI and plantar fascia; BSA; HAQ and fatigue by FACIT 4 scale were evaluated. A score FACIT <30 indicates severe fatigue, the higher the score – the better the quality of life. All pts were given therapy with Methotrexate (MTX) s/c, 29 pts with ineffectiveness of MTX after 3–9 mo of treatment were added biologic DMARDs. The one-factor model of logistic regression was used to identify a group of features that are associated with achievement MDA.Results. By 12 mo of therapy, the proportion of pts who have reached MDA (5/7) were calculated. Pts were split into 2 groups: MDA+ (n=45) and MDA– (n=32).Comparative analysis of BL features in both groups and one-factor model of logistic regression showed the following features were associated with achievement MDA: TJC and SJC<3 (p<0.001); PGA≤20 mm (p<0.001); pain≤15 mm (p<0.001); CRP≤5 mg/l (p<0.03); HAQ≤0.5 (p<0.001); FACIT>30 points (p<0.021); absent of entesitis (p<0.003), dactylitis (p<0.029) and nail damage (p<0.012). Early PsA pts with combination of these features on first visit have more chance to achieve MDA in comparison to PsA pts without them (OR=9.684 [95% CI: 4.6–20.4]).Conclusion. It is a combination of features on first visit – oligoarthritis, moderate activity, absent of entesitis, dactylitis, nail psoriasis, significant impact on function and fatigue – that constitutes a clinical prognostic factors for achievement MDA after 12 mo of treatment in pts with early PsA according T2T.
Polymorphism rs10499194 of the TNFA1P3 gene is not associated with a predisposition to ankylosing spondylitis in the Russian cohort of patients
Authors: Krylov M. Yu. , Erdes Sh. F. , Konovalova N. V. , Varlamov D. A.
Published: December 2022

Background. Recently, numerous studies have shown that TNFAIP3 gene polymorphisms have been associated with susceptibility to certain autoimmune inflammatory diseases, including systemic lupus erythematosus, scleroderma, rheumatoid arthritis and psoriasis. However, the results of studies devoted to the study of associations between TNFAIP3 gene polymorphisms and the risk of ankylosing spondylitis (AS) are ambiguous and few.The aim of the study was to study the possible association of hs10499194 polymorphism of the TNFAIP3 gene with a predisposition to AS and its clinical phenotypes.Material and methods. The rs10499194 S/T polymorphism of the TNFA1P3 gene was studied in two hundred patients with AS (130 men and 70 women). All patients were diagnosed with AS, according to the modified New York criteria, 1984 and high activity of the disease. Demographic and clinical-serological characteristics were studied in all patients. The average age of patients was 39.4±12.6 years; the average duration of the disease was 15.0±10.6 years. Out of 200 patients, 175 (87.5%) were seropositive for HLA-B27 antigen. Extra axial arthritis was detected in 125 (62.5%) patients, 148 (74.0%) had enthesitis, 137 (68.5%) had coxitis. The polymorphism rs10499194 of the TNFAIP3 gene was studied using an allelespecific polymerase chain reaction in real time (PCR-RV) using the Synthol kit.Results. The analysis of the frequencies of genotypes and alleles did not show significant differences with the control group. Stratification by sex, age, and clinical manifestations showed an association of the CT genotype with an increased risk of AS among men (OR=2.24; p=0.010), the TT genotype and the T allele with a high risk of predisposition to the development of extra axillary peripheral arthritis (OR=3.94; p=0.019 and OR=1.64; p=0.027 respectively). The BASDAI index was statistically significantly higher in carriers of the TT genotype compared to the CT genotype (p=0.002).Conclusion. The present study confirmed the association of the genetic polymorphism rs10499194 of the TNFAIP3 gene with AS. Stratification by gender and clinical manifestations showed an association of the CT genotype with an increased risk of AS among men, the TT genotype and the T allele with a high risk of predisposition to the development of extra axillary peripheral arthritis and a high BASDAI index in carriers of the TT genotype.
Sur l’expansion des fourmis envahissantes du genre Tapinoma en France (Hymenoptera : Formicidae)
Authors: Lenoir Alain , Mercier Jean-Luc , Perdereau Elfie , Berville Laurence , Galkowski Christophe
Published: December 2022

On the expansion of Tapinoma invasive ants in France (Hymenoptera: Formicidae). - The invasive ant Tapinoma magnum has been reported in various places in southwestern France (LENOIR & GALKOWSKI, 2017). This ant seems to spread rapidly in this region from Toulouse to Lyon region, as well as in the Loire Valley and Brittany. It is a big problem for example in Saumur where people cannot access their lawns. Two other species, T. ibericum and T. darioi, are reported from other places up North but do not present a threat currently. The tropical ghost ant T. melanocephalum is also signaled in some places in houses or flats whereas it was only localized in tropical greenhouses.
Pengaruh Likuiditas, Profitabilitas, Solvabilitas terhadap Returun Saham Pada Masa Pandemi Covid – 19:
Authors: Peso Vivi Oktaviana , Wiyono Gendro , Prima Sari Pristin
Published: December 2022

“The Fundamental Influence of Bank Finance Companies on Stock Returns during the Covid-19 Pandemic (study of T-shirts at National Private Banks for the period 2018-2022) listed on the Indonesia Stock Exchange. Aims to answer problems regarding the Effect of Current Ratio, Debt to Equity and Return on Assets on Stock Return of Bank Financial Companies during the Covid-19 pandemic. In this study, the method used was a quantitative approach. The population in this study were 30 National Private Bank Companies. Sampling was carried out using a non-probability method and the sampling technique was purposive sampling. The data were analyzed using the IBM SPSS application. The results of the study show that the Current Ratio (X1) variable has a significant effect on Stock Return (Y), as evidenced by the results of the t test, which is obtained from the t arithmetic value of 2,566 > t table 1.729 and Significant 0,013 < from 0,05. Then the variable Debt To Equity Ratio (X2) has no significant effect on Stock Return (Y) as evidenced by the results of the t test, which is obtained from the t-count value of -809 < 1.729 and significant 0.422 > 0,05. And the Return on Assets (X3) variable has no effect on Stock Return (Y), as evidenced by the results of the t test, which is obtained from the t value of 1,270 < 1,729 and significant 0,209 > 0,05. And from the results of the F test, it is proven that the Curent Ratio (CR,) Debt to Equity Ratio (DER), and Return on Assets (ROA) have a simultaneous effect on Stock Return (Y).

Keywords: Current Ratio, Debt to Equity Ratio, Return on Assets, Stock Return
Pengaruh ROE dan DER terhadap Harga Saham pada Perusahaan Sektor Pertambangan Minyak & Gas yang Terdaftar di BEI Periode 2016-2020
Authors: Sudira Wizar , Sulistiyo Hari
Published: December 2022

Indonesia is a country with a large population, which will result in a fairly large level of energy demand and one of them is the need for oil and gas. In conditions of global instability and limited supplies of oil and gas resources, this will also have an impact on the condition of companies in this sector in Indonesia. This study aims to examine, identify, and analyze the effect of the ROE and DER ratios on stock prices in oil and gas mining companies listed on the Indonesia Stock Exchange for the 2016-2020 period. The research method used is descriptive verification, and the number of samples taken from the population is 6 out of 13 companies. The sampling technique used is purposive sampling and uses multiple linear regression analysis tools and uses SPSS analysis tools with the results of DER not having an effect on stock prices and ROE having an effect on stock prices and DER and ROE simultaneously having an effect on stock prices.

Keywords: Return on Equity; Debt to Equity Ratio; Stock Price
Pengaruh Keputusan Investasi, Kebijakan Hutang, dan Profitabilitas terhadap Nilai Perusahaan Sektor Food and Beverages yang Terdaftar di BEI Periode 2019-2021
Authors: Oktavia Sari Vika Ayu , Yudiantoro Deny
Published: December 2022

This study aims to analyze the effect of investment decisions, debt policy and profitability partially and simultaneously on the value of companies in the Food and Beverages sector listed on the IDX for the 2019-2021 period. This research uses a quantitative approach with sampling technique using purposive sampling method, in order to obtain 25 companies from 72 companies. The data analysis technique used in this research is panel data regression analysis at a significance level of 5%. The program used in analyzing the data uses Eviews 9.0. The results of this study indicate that partially investment decisions and profitability have a significant effect on firm value while debt policy has no significant effect on firm value. The results of this research simultaneously show that investment decisions, debt policies and profitability have a significant effect on firm value.

Keywords: Investment Decision, Debt Policy, Profitability, Firm Value
Strategi Pemasaran Syariah Busana Muslim ‘Hana_Nadhira’ untuk Meningkatkan Profitabilitas
Authors: Kurniadin Giri , Muhlisin Sofian , Gustiawati Syarifah
Published: December 2022

Intense competition in the era of digital marketing and the use of social media requires entrepreneurs to adapt and formulate marketing strategies to survive and develop businesses. In the midst of business competition in capturing the market, fraud and fraudulent actions are vulnerable to be carried out. Moral and Islamic values are important to be implemented in the business operations that are carried out. Hana Nadhira is a business brand that was founded by a married couple and managed to take advantage of business opportunities through digital media with encouraging developments. This research is a qualitative research with the aim of analyzing how sharia marketing is implemented by Hana Nadhira Clothing in increasing profitability. The results of the research show that Hana Nadhira has succeeded in developing from a minimal profit with a narrow market coverage to a profitable business with a turnover of more than Rp. 50,000,000 per month and market penetrating overseas market. Continuous quality improvement in terms of products, promotions that are updated based on trends, as well as the use of communication media that is busy being used are the keys to the success of the business.

Keywords: Sharia Marketing, Profitability
Pengaruh Harga dan Kualitas Produk terhadap Keputusan Pembeli Minuman Yotta di Samata Kabupaten Gowa
Authors: Iin Mutmainnah , Fathurrahman Fathurrahman , Khatman Muh.Nasri
Published: December 2022

In improving marketing and sales stategis, i tis urgently needed to influence the price and product quality. The price of a product is very significant in providing value to consumers to buy a product. Prices that match the quality of the product, consumers will be interested in buying the product because consumers are not always fixated on low prices. In the research that has been carried out on the influence of the price and quality of brand beverage products in Makassar, namely Yotta drinks, where this drink is a drink that has excelled in sales throughout South Sulawesi and has many enthusiasts. The results of the study using a quantitative descriptive type approach method with Primary and secondary data sources showed that the price had a significant influence on the decisions of Yotta drink buyers, and the quality of this product had a positive influence on the decisions of Yotta drink buyers. So the conclusion from the results of this study is that the price and quality of these products both have a positive influence on the decision to purchase Yotta drinks in Samata, Gowa Regency.

Keywords: price; product quality; buyer's decision; yotta drinks
Pengaruh Motivasi Kerja, Disiplin Kerja dan Lingkungan Kerja terhadap Produktivitas Kerja pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Gunungkidul
Authors: Pramana Huda , Herawati Jajuk , Septyarini Epsilandri
Published: December 2022

This study aims to analyze (1) the effect of work motivation on work productivity (2) The effect of work discipline on work productivity. (3) the influence of the work environment on work productivity. (4) the effect of work motivation, work discipline and work environment on work productivity. The population in the study were all employees of the Gunungkidul Regency Population and Civil Registration Office, totaling 66 people. All employees are taken data or census using a questionnaire instrument. The data analysis methods used in this study are validity test, reliability test, classic assumption test, and multiple linear regression test with the IBM SPSS Version 26 tool program. The data analysis was carried out to identify independent variables that affect the dependent variable. The results of the study found that (1) work motivation has a positive and insignificant effect on work productivity. (2) Work discipline has a positive and significant effect on work productivity. (3) The work environment has a positive and significant effect on work productivity. (4) work motivation, work discipline and work environment together have a significant positive effect on work productivity.

Keywords: Work Motivation, Work Discipline, Work Environment, Work Productivity
Pengaruh Budaya Organisasi Dan Motivasi Terhadap Kinerja Tenaga Pendidik
Authors: Dayona Gurawan , Lusyana Sari Luska , Nur Sumawidjaja Riyandi , Sudaryo Yoyo
Published: December 2022

The purpose of this study was to determine the effect of organizational culture and motivation on the performance of teaching staff at MedikaCom Vocational High School. This research uses descriptive verification method. Data was collected through a survey of all teaching staff at the MedikaCom Vocational High School. The data is processed using a statistical application with the method of path analysis (path analysis). The results showed that the conditions of organizational culture, motivation and performance of teaching staff were in the Good category. This study also shows that there is a strong correlation between organizational culture, motivation, and performance. Processed data confirms that organizational culture and motivation have a positive and significant effect on performance. The influence of organizational culture and motivation on the performance of teaching staff at Medikacom Vocational High School can be seen from the value of the coefficient of determination (R2) or R Square of 0.789. These results indicate that the simultaneous contribution of organizational culture and motivation to performance is 78.9%. While the remaining 21.1% is the influence of other variables (epsilon) that were not examined by the authors.
Rancang Bangun Sistem Pendukung Keputusan Pemilihan Sales Terbaik pada PT Caturadiluhur Sentosa Menggunakan Metode SAW
Authors: Rizki Ampu Syura , Yulistia Yulistia
Published: December 2022

PT Caturadiluhur Sentosa Palembang is a company engaged in the distribution, logistics, and retail of building materials. PT Caturadiluhur Sentosa Palembang has several obstacles, namely the criteria for determining the best current sales by determining the largest turnover only. So that the current best sales appraisal system is considered less effective and unfair. The system built aims to build the best sales decision support system that can manage sales data and assessment parameters properly. The system built can manage sales data, criteria data, store sales appraisal data, and calculate sales value using the SAW method. The system is built using the iteration method. The result of this research is a decision support system that gives the best sales ranking based on the results of the assessment calculated using the SAW method.

Keywords: Decision Support System, Iteration, SAW
Analisis Penerapan Akuntansi Dana Sosial Pada Musyawarah Desa Pertanggungjawaban (MDPT) di BUMDESa Lancang Kuning Desa Rumbai Jaya
Authors: Mlyti Nur Aisiyah
Published: December 2022

The purpose of this study was to analyze the application of social fund accounting at the accountability village meeting (MDPT) in the BUMDes of Lancang Kuning, Rumbai Jaya Village. The technique is carried out using descriptive qualitative data obtained by case studies obtained by researchers. In general, the accounting applied by BUMDes is very good, for statements of financial position, activity reports, cash flow reports, and notes on financial statements in PSAK 45, there is already a separator in BUMDes.

Keywords: PSAK 45, Social Funds, BUMDes.
Pengaruh Promosi Penjualan, Persepsi Manfaat dan Persepsi Kemudahan terhadap Minat Menggunakan E-Wallet Shopeepay Pada Mahasiswa Universitas Singaperbangsa Karawang
Authors: Syukriyyah Syukriyyah , Karyaningsih Karyaningsih
Published: December 2022

This study aims to analyze the effect of sales promotion, perceived usefulness and perceived ease of use of interest in using shopeepay e-wallet in Singaperbangsa Karawang University students. This study uses a descriptive verification approach with quantitative methods, with the help of Microsoft Excel and SPSS software. Data collection in this study was carried out by distributing questionnaires via google form. The population in this study were all students of the University of Singaperbangsa Karawang 2021. The sample was taken using the probability sampling with the proportionate stratified random sampling technique, with a sample of 392 respondents. The test stages used are: validity test, reliability test, classical assumption test, multiple linear regression, hypothesis testing and coefficient of determination. The results of this study indicate that the variables of sales promotion, perceived usefulness and perceived ease of use partially have a positive effect on the interest in using shopeepay e-wallet in Singaperbangsa Karawang University students with 23.4%, 19% and 27.2% respectively. Meanwhile, simultaneously, sales promotion variables, perceived usefulness and perceived ease of use, affect the interest in using shopeepay e-wallet among Singaperbangsa Karawang University students. Together, they have an effect of 54.3% on interest in using shopeepay e-wallet and the remaining 45.7% is influenced by other variables which is not examined.

Keywords: Sales Promotion, Perceived usefulness, Perceived ease of use and Interest in Using e-wallet Shopeepay
Pengaruh Deskripsi Pekerjaan terhadap Kinerja Satpam PT Satria Sriwijaya Sejahtera
Authors: Ningtiyas Sekar Ayu , Perizade Badia , Farla Wita
Published: December 2022

This reseacrh aims to determine the effect of job descriptions on the performance of PT Satria Sriwijaya Sejahtera security guards. This study used quantitative methods with a questionnaire as a research instrument. The population in this study amounted to 35 people with 35 respondents. The sampling technique used is the census technique or total sampling. The data analysis technique used is simple linear regression. The findings of this research showed that there was a positive and significant effect between job descriptions on the performance of PT Satria Sriwijaya Sejahtera security guards. From the aspects that have been researched, it is better for the management of PT Satria Sriwijaya Sejahtera to explain more about SOPs and job descriptions of security guards to members of their security guards and pay more attention to aspects that can affect the performance of security guards so that the performance of security guards can increase.

Keywords: Job Description, Employee Performance
Pengaruh Pengembangan Karir Terhadap Prestasi Kerja Guru SMP Negeri 47 Palembang
Authors: Redian Daffa Akbar , Hanafi Agustina , Santati Parama , Andriana Isni
Published: December 2022

This research aims to determine the effect of career development on teacher work achievement at SMP Negeri 47 Palembang. The population in this study were all teachers at SMP Negeri 47 Palembang using a sample of 41 respondents. The data collection method used in the study was obtained from a questionnaire. The analysis technique used is simple linear regression analysis. The data obtained were tested using validity test, reliability test, simple linear regression test, analysis of correlation coefficient (r) and coefficient of determination (R2), as well as hypothesis testing or t test. The test was carried out using the statistical package for social science (SPSS) version 21. Based on the results of the analysis, it was concluded that career development had a positive and significant effect on teacher work achievement at SMP Negeri 47 Palembang.

Keywords: Teacher, Work Achievement, Questionnaire, Career Development.
The Pengaruh Stres Kerja terhadap Kinerja Karyawan PT. Bank Rakyat Indonesia Kantor Cabang A. Rivai Palembang
Authors: Afda M Rafli , Andriana Isni , Siregar Lina Dameria
Published: December 2022

This study aims to determine the effect of work stress on employee performance at PT. Bank Rakyat Indonesia Branch Office A. Rivai Palembang. The population in this study were all employees at PT. Bank Rakyat Indonesia Branch Office A. Rivai Palembang using a sample of 60 respondents. The data collection method used in the study was obtained from a questionnaire. The analysis technique used is simple linear regression analysis. Data processing in this study using the SPSS software program (version 24.00). Based on the results of the analysis, it was concluded that work stress had a negative and significant effect on employee performance at PT. Bank Rakyat Indonesia Branch Office A. Rivai Palembang.

Keywords: Job Stress; Performance; Employees.
Yaratıcı Dramanın İlköğretim 4. Sınıf İnsan Hakları, Yurttaşlık Ve Demokrasi Dersinde Kullanılması
Authors: ALATAŞ Ferhat , TURAN İlhan
Published: December 2022

Bu araştırmada, insan hakları, yurttaşlık ve demokrasi dersinde akademik başarı ve öğrencilerin etkin vatandaş olarak yetiştirmede, yaratıcı drama tekniğinin önemi ve etkileri araştırılmıştır. Araştırmanın uygulaması, 2017- 2018 Eğitim-Öğretim Yılı’nda Kayseri İli Kocasinan İlçesi’nde bir ilkokulda gerçekleştirilmiştir. Araştırmanın deney grubunu 23 kontrol grubunu 24, 4. sınıf öğrencisi oluşturmaktadır. Araştırmada karma yöntemin açıklayıcı ardışık deseni tercih edilmiştir ve deney ve kontrol gruplu yarı deneysel çalışma yapılmıştır. Araştırmanın, nicel bölümünde ön test-son test uygulamaları yapılmıştır. Yaratıcı drama kullanarak hazırlanan ders planları aracılığı ile deney grubunda uygulama yapılırken, kontrol grubunda müdahalesiz öğretim yapılmıştır. Araştırma bir plan dahilinde 6 hafta sürmüştür. Öğrenci başarı testi ve etkin vatandaşlık ölçeğinden alınan veriler yorumlanmıştır. Bunun yanında yaratıcı drama uygulamaları hakkında deney grubu ilkokul öğrencilerinin görüşleri nitel yöntem çerçevesinde alınmıştır. Araştırma bulgularına göre, yaratıcı dramanın insan hakları, yurttaşlık ve demokrasi dersinde öğrencilerin akademik başarısına etkisine ilişkin anlamlı fark bulunmamıştır, fakat başarı puanlarında artış olmuştur. Etkin vatandaşlık testinden elde edilen bulgularda da benzer durum söz konusudur. Nitel verilerden elde edilen bulgular yaratıcı dramanın olumlu yönlerine dikkat çekmektedir.
İki Farklı Zaman Aralığı ve İki Ayrı Merkezdeki Kolorektal Cerrahide Anastomoz Kaçaklarımızın Literatür Eşliğinde Değerlendirilmesi
Authors: NAZLI Okay
Published: December 2022

Kolorektal cerrahide en önemli ve korkulan komplikasyonlardan biri anastomoz kaçakları ve buna bağlı pelviperitoneal sepsistir. Kolorektal cerrahide mortalitenin %30-50’sinden anastomoz kaçakları sorumludur. Mortalite oranını, kaçağın erken tanınması ve yandaş hastalıklar belirler. İzmir Atatürk Eğitim ve Araştırma Hastanesi 3.Genel Cerrahi Kliniği’nde (İAEAH) 2000-2008 yılları arasında opere edilen kolon ve rektum kanseri olgularının yayınlanmamış olan verileri ile halen çalışmakta olduğum Muğla Sıtkı Koçman Üniversitesi Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği’nde (MSKÜEAH) 2012-2021 yılları arasında cerrahi tedavi gören kolon ve rektum olgularının verileri retrospektif olarak incelenmiştir. Belirtilen dönemler içerisinde, İAEAH çalışmasında 216, MSKÜEAH’de ise 251 cerrahi tedavi uygulanan kolorektal kanser olgusu saptanmıştır. Bu retrospektif çalışmada uygulanmış olan kolorektal cerrahi sonrası gelişen anastomoz kaçakları değerlendirilmiştir. Anastomoz kaçaklarının, reoperasyon olasılıkları, cerrahi morbidite ve mortalitenin, hastanede yatış süresinin ve hastaneye tekrar gelişin, lökorejyonel nüks riskinin artışı, beş yıllık genel sağ kalımın azalması ve hastaların yaşam kalitesinin düşmesi ve maliyet gibi olumsuz sonuçlarının daima hatırlanarak, kaçak önleyici tedbirlerin artırılması ve bunun için de yeni klinik çalışmaların yapılması gerekmektedir. Bu çalışmanın amacı cerrahi teknik, radyoloji, yoğun bakım gibi önemli alanlarda ilerlemelerin, iki ayrı merkezde farklı çalışma dönemlerinde kolorektal cerrahi uygulanan olgularda anastomoz kaçaklarına olan etkilerini araştırmaktır.
Were appendicitis’ more complicated in the Covid-19 pandemic?
Authors: YAVUZ Aydın , GÖBÜT Hüseyin , ÖZAYDIN Safa , DİKMEN Kürşat , BOSTANCI Hasan
Published: December 2022

To investigate the frequency of patients operated for acute appendicitis during the COVID-19 pandemic period, their complication rates and how it affected hospital costs. In this retrospective study, the data of patients who were operated with the diagnosis of acute appendicitis during the Covid-19 pandemic period (15 March - 31 May 2020) were compared with the data of those operated in the non-pandemic period (15 March - 31 May 2019). Patients who were operated during the COVID-19 pandemic period were categorized as Group A and those operated in the non-pandemic period as Group B. The clinicopathological characteristics of patients, the incidence of the disease, whether the disease was complicated, and the hospital costs were analyzed. Of a total of 108 patients meeting the study criteria, 46 were assigned to Group A and 62 to Group B. When the appendix diameters were compared, the mean appendix diameter of the patients in Group A was higher than that of the patients in Group B (8±SD mm vs. 7±SD mm, p< 0.001). The mean operative time of the patients in Group A was longer than that of the patients in Group B (47.5±15.41 minutes vs. 40±9.61 minutes, respectively, p < 0.001). Intraabdominal drain was required in 10 patients (21.7%) in Group A and 4 patients (6.5%) in Group B (p=0.039). All the wound infections developed in Group A in open operations. When the cost analysis between the groups was compared, the mean cost per patient in Group A was 1284.10±804.11 TL, while it was 1066.43±671.28 TL in Group B, and the difference between the groups was statistically significant (p=0.040). During the Covid-19 pandemic, patients who were operated with the diagnosis of acute appendicitis became more complicated, and the morbidity and hospital costs of patients increased.
Sıvı Bazlı Sitoloji, HPV-DNA Genotiplendirme ve Kolposkopik Biyopsi Sonuçlarının Değerlendirilmesi: 407 Vakanın Analizi
Authors: TURHAN Ezgi Işıl , NALBANT Melike , BAYRAK Mehmet
Published: December 2022

Bu çalışmanın amacı Bursa ilinde en sık rastlanan HPV tiplerini belirlemek, bu tiplerle ilgili olarak eş zamanlı sıvı bazlı sitoloji ve kolposkopik biyopsi sonuçlarının tutarlılığını araştırmaktır. Retrospektif çalışmamıza Ekim 2019-Mayıs 2020 tarihleri arasında hastanemizde servikal smear örneklemesi yapılan ve eş zamanlı olarak real time PCR yöntemi ile yüksek riskli HPV-DNA genotip tayini yapılmış 407 hasta dahil edildi. Çalışmamızda yüksek riskli HPV görülme oranımız %18 bulundu. İzole olarak bakıldığında en sık görülen yüksek riskli HPV tipi, tip 16 (%32.5) bulundu. HPV pozitifliği saptanan 77 hastada smearde %28.5 oranında önemi belirlenemeyen atipik skuamöz hücreler (ASC-US), %7.7 oranında düşük dereceli skuamöz intraepitelyal lezyon (LSIL), %3.8 oranında yüksek dereceli skuamöz intraepitelyal lezyon (HSIL) saptandı. SIL saptanan beş hastanın ikisinde biyopside servikal intraepitelyal neoplazi 1 (CINI), üçünde ise servikal intraepitelyal neoplazi 3 (CIN3) saptanmıştır. HPV testinin smear ile eş zamanlı yapılması taramanın sensivitesini yüksek dereceli lezyonların saptanma olasılığını artırmaktadır.
Dikkat Eksikliği ve Hiperaktivite Bozukluğu Tanısı Alan Çocuk ve Ergenlerde Uzun Süreli Metilfenidat Kullanımının Büyüme ve Kemik Yoğunluğu Üzerine Etkilerinin Araştırılması
Authors: ŞAHİN Zeynep Anıl , ŞAHİN İsmail Gökhan , BOZATLI Leyla , GÖRKER Işık
Published: December 2022

Bu çalışmamızdaki amacımız, Dikkat Eksikliği ve Hiperaktivite Bozukluğu (DEHB) tanılı olgularda en sık kullandığımız farmakolojik tedavi ajanı olan metilfenidatın büyüme ve kemik yapısı üzerine etkilerini araştırmaktır. Trakya Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı tarafından DEHB tanısı ile takip edilen; 30 erkek vaka, olgu grubu olarak çalışmaya dahil edildi ve benzer yaş grubundaki kontrol grubu ile karşılaştırıldı. Gruplar; yaş (yıl), boy uzunluğu (cm), vücut ağırlığı (kg) ve vücut kitle indeksi (kg/m2), 25-hidroksikolekalsiferol (Vitamin D), serum kalsiyum değerleri (mg/dl) ve DEXA (Dual enerjili x-ray absorpsiyometrisi) sonuçları ile karşılaştırılarak değerlendirildi. Çalışmamızda büyüme parametreleri [boy(cm), vücut ağırlığı (kg), vücut kitle indeksi (kg/m2)], Vitamin D düzeyleri, lomber ve kalça kemik mineral yoğunluğu açısından gruplar arasında istatistiksel olarak anlamlı fark saptanmadı. Serum kalsiyum düzeyleri, proksimal femur ve lomber vertebra Z skorlarının olgu grubunda istatistiksel olarak anlamlı düzeyde düşük olduğu tespit edildi (p=0.001; p=0.013; p=0.015). Metilfenidat tedavisi, DEHB olgularında altın standart farmakolojik tedavidir. Literatürde hiçbir çalışmada DEHB olgularında metilfenidat kullanımına bağlı olarak kontrol grubuna kıyasla daha iyi büyüme parametreleri ve kemik yoğunluğu saptanmamıştır. Literatürle uyumlu olarak çalışmamızda büyüme parametreleri açısından gruplar arası fark saptanmadı. Kemik parametrelerinde ise, kalça ve lomber vertebra Z skorları ve serum kalsiyum düzeylerinin olgu grubunda istatistiksel olarak anlamlı düzeyde düşük olduğu tespit edildi. Vitamin D düzeyleri açısından gruplar arası istatistiksel olarak anlamlı fark tespit etmemiş olmamıza rağmen ortalama değerler açısından olgu grubumuzun Vitamin D eksikliği, kontrol grubumuzun ise Vitamin D yetersizliği tanımına uymasının önemli olduğunu düşünüyoruz.
Higher Survival Advantage with Hyper-CVAD Chemotherapy Regimen Before Allogeneic Stem Cell Transplantation in Patients with High Risk Adult Acute Lymphoblastic Leukemia: Two-Center Experience
Authors: KILIÇASLAN Emrah , SAYIN Selim , YILDIRIM Murat , ELİBOL Tayfun , GÖZDEN Hilmi , AYLI Meltem , KAPTAN Muhammet
Published: December 2022

While promising results have been achieved in the treatment of childhood, the optimal initial treatment for adult acute lymphoblastic leukemia (ALL) has not yet been defined. Hyper-CVAD has become a widely used treatment for approximately 2 decades in the treatment of adult ALL. We conducted a retrospective analysis of 30 patients treated with Hyper-CVAD at two centers between 2014 and 2020. In all (n=30) patients treated with Hyper-CVAD, complete response (CR) rate was 86.7%, induction mortality was 10%, refractory disease was 3.3%, the median overall survival (OS) was 38 months (95% CI 7.78–68.2 months), the median disease-free survival (DFS) was 29 months (95% CI 9–49 months), the 2-year OS rate was 56.5%, and the 2-year DFS was rate 56.7%. For standard risk (n=12) ALL patients, the median OS was 20 months (95% CI 0–43 months), and median DFS was 7 months (95% CI 0–25 months). For high risk (n=18) ALL patients, the median OS was 38 months (95% CI 0–76 months), and median DFS was not reached. These results indicate that Hyper-CVAD regimen should be considered as an option for induction treatment of adult ALL patients who are newly diagnosed and eligible for allo-HSCT.
Pediatric Maxillofacial Trauma: Epidemiologic Study Between 2015 and 2020
Authors: ÖZDEMİR KAÇER Emine , KAÇER İlker , ÇAĞLAR Ahmet
Published: December 2022

Maxillofacial trauma is the most common type of trauma and is an important cause of high morbidity and mortality. Emotional traumas occur in children due to sequelae caused by injuries and the rest of their lives are negatively affected. The aim of this study is to investigate the etiology, epidemiology, and injury type of pediatric maxillofacial traumas, and to make recommendations to prevent child injuries. This descriptive retrospective study was conducted in a regional tertiary hospital. The medical records of all maxillofacial trauma-related admissions to the emergency department between January 2015 and February 2020 were retrospectively reviewed. Etiology of trauma, demographic characteristics, type of trauma, accident type, injury site, administered treatments, and mortality were recorded. 1029 patients aged 4 months-18 years (mean 77.67±59.21 months) including 288 females (28%) and 741 males (72%) were included in the study. Most of the patients (n=390, 37.9%) were in the 13-18 age group. The vast majority of the study population lived in the urban area (n=753, %73.2). Most injuries were seen in the summer (n=438, %42.6). After head+cervical injuries, upper extremity injuries (n=171, %16.6) were the most common and thoracic injuries (n=69, %6.7) least. 57 (5.5%) patients were required hospitalization and the mortality rate was 1.2% (n=12). Pediatric maxillofacial traumas occur mostly in the male gender, in summer, in urban areas, and due to motorcycle accidents. In order to reduce child maxillofacial traumas, public awareness should be increased and playgrounds suitable for all age groups should be created.
The Predictive Impact of Frailty Index on Outcomes Following Emergency Colectomy for Obstructing and Perforated Colon Cancer
Authors: HACIM Nadir Adnan , TOKOCİN Merve , MERİC Serhat , VARTANOGLU AKTOKMAKYAN Talar , CHUNG Soon Sup , AKTİMUR Yunus , GÜLLÜ Haşim Furkan , ALTINEL Yuksel
Published: December 2022

This study aimed to analyze the predictive impact of frailty index and patterns of outcomes in patients with obstructing and perforated colon cancer who had emergency surgery. The nighty-nine patients who underwent right and left hemicolectomy were retrospectively evaluated within emergency conditions such as obstruction or perforation of tumor between February 2017 and October 2020. The 5-mFI (modified frailty index) score was measured by multiplying each number of frailty features (1 point per each existence; 0 - 5 points) and categorized into three groups (mFI=0, mFI=1, and mFI ≥ 2). The average age of the patient population was 65.21±13.84 years old. The male patients were 60 (60%). Albumin level was seen lower in patients who had higher mFI (3.86±0.63vs. 3.51±0.76 vs. 3.51±0.65, p=0.045). The predictive outcomes regarding the mFI potentially showed increased Clavien Dindo classification (CDC) [OR: 1.49, 95%CI: 0.82-2.75, p=0.2], morbidity [OR: 2.43, 95%CI: 0.50-13.98, p=0.3], and leakage [OR: 2.02, 95%CI: 0.63-6.65, p=0.2]. The morbidity (16, 24.6% vs. 16, 47.1%), p=0.041) and mortality (10, 15.4% vs. 9, 26.5%, p=0.289) were more likely seen for right sided tumors. Stoma formation was seen more likely for left sided tumors (29, 60% vs. 8, 23.5%, p=0.001). The 5-mFI score might be assumed as a preoperative prognostic tool for emergency colon surgery considering morbidity, mortality, prolonged hospitalization, and reoperation. Although morbidity and mortality in right-sided tumors and stoma formation are higher in left-sided tumors, 5-mFI score can be evaluated in patients regardless of colon cancer location.
Preeklamptik Gebelerin Hemogram Parametreleri ve Gebelik Seyirlerinin Normal Gebelerle Karşılaştırılması
Authors: DEMİREL Funda , SARIİBRAHİM ASTEPE Bahar
Published: December 2022

Bu çalışmada preeklamptik gebelerin normal gebelerden farklı olabilecek hemogram parametrelerini tespit etmek ve yine gebelik seyrinde preeklamptik gebelerde görülebilecek diğer sistemik hastalıkları saptamak, preeklamptik gebelerin gebelik seyir ve sonuçlarını incelemek amaçlanmıştır. Araştırma 2017/2020 yılları arasında bir eğitim ve araştırma hastanesinin kadın doğum kliniğine başvuran ve 80 preeklampsi tanısı almış ve 100 normal gebelik süreci geçiren hastalara ait dataların retrospektif olarak taranmasıyla gerçekleştirilmiştir. Her iki grupta da bulunan gebelerin hemogram parametreleri karşılıklı olarak incelenmiştir. Ayrıca gebelik seyirlerinde preeklampsiye eşlik eden başka bir hastalık gelişip gelişmediği, hastaların kaçıncı gebelik haftasında doğum yaptıkları, doğum şekilleri, bebeklerin doğum ağırlıkları ve cinsiyetleri de karşılaştırılmıştır. Araştırmada preaklamptik gebelerin, normal gebelere göre Hemoglobin (Hb), Kırmızı kan hücresi (Rbc), Hematokrit (Hct), Ortalama eritrosit hemoglobin konsantrasyonu (Mchc), Lokosit (Wbc), Trombosit (Plt), Nötrofil (Neu), Monosit (Mo), Lenfosit (Ly) ve Trombosit dağılım genişliği (Pdw) değerlerinde istatistiksel olarak anlamlı farklılıkların olduğu belirlenmiştir (p<0.05). Ortalama Eritrosit Hemoglobin (Mch), Eritrosit dağılım genişliği (Rdw), Ortalama korpüsküler hacim (Mcv), Ortalama trombosit hacmi (Mpv), Eosonofil ve Bazofil değerlerinde ise preaklamptik gebelerle normal gebeler arasında istatistiksel olarak anlamlı farklılıkların olmadığı saptanmıştır (p> 0.05). Ayrıca preeklamptik gebelerin %10’unda gestasyonel diabet de eşlik ettiği %1’inde diabet bulunduğu, %1’inde gebelik kolestazı geliştiği belirlenmiştir. Hastaların %3’ünde ise tansiyon yüksekliğine bağlı dekolman geliştiği saptanmıştır.