bluuebunny/crossref_metadata_2025 huggingface dataset:
Difference of Risk of Pancreatic Cancer in New-Onset Diabetes and Long-standing Diabetes: A Population-based Cohort Study
Authors: Lee Hee Seung , Chae Wonjeong , Sung Min Je , Keum Jiyoung , Jo Jung Hyun , Chung Moon Jae , Park Jeong Youp , Park Seung Woo , Song Si Young , Park Eun-Cheol , Nam Chung Mo , Jang Sung-In , Bang Seungmin
Published: December 2022

Context

Considering the absence of methods to find pancreatic cancer early, surveillance of high-risk groups is needed for early diagnosis.

Objective

The study aimed to investigate the effect in the incidence of pancreatic cancer and the differences between new-onset diabetes mellitus (NODM) and long-standing DM (LSDM) since NODM group is a representative high-risk group.

Methods

The Korean National Health Insurance Service–National Sample Cohort between 2002 and 2013 data were used. Regarding 88 396 people with DM (case group), we conducted a 1:1 propensity score matching to select a matched non-DM population (control group). To investigate the interaction between DM and the time variable distinguishing NODM and LSDM, we performed a multivariate time-dependent Cox regression analysis.

Results

The incidence of pancreatic cancer was higher in the DM group compared to the non-DM group (0.52% vs 0.16%; P < .001). The DM group had shown different risk of pancreatic cancer development according to the duration since the DM diagnosis (NODM hazard ratio (HR): 3.81; 95% CI, 2.97-4.88; P < .001; LSDM HR: 1.53; 95% CI, 1.11-2.11; P < .001). When the NODM and the LSDM groups were compared, the risk of pancreatic cancer was higher in the NODM group than in the LSDM group (HR: 1.55; P = .020). In subgroup analysis, NODM group showed that men (HR = 4.42; 95% CI, 3.15-6.19; P < .001) and patients who were in their 50 seconds (HR = 7.54; 95% CI, 3.24-17.56; P < .001) were at a higher risk of developing pancreatic cancer than matched same sex or age control group (non-DM population), respectively.

Conclusion

The risk of pancreatic cancer was greater in people with DM than in a non-DM population. Among people with DM, NODM showed a higher risk of pancreatic cancer than LSDM.
Approach to the Patient: Management of Parathyroid Diseases Across Pregnancy
Authors: Appelman-Dijkstra Natasha M , Pilz Stefan
Published: December 2022

Taking care of patients with parathyroid disorders during pregnancy requires consideration of the physiological fundamental changes in bone and mineral metabolism occurring in these women. Diagnostic and therapeutic procedures regarding primary hyperparathyroidism (PHPT) and hypoparathyroidism significantly differ from the nonpregnant population. PHPT should preferably be cured by parathyroidectomy before pregnancy since in women with hypercalcemic PHPT, maternal and fetal pregnancy complications seem to increase according to the degree of hypercalcemia. Parathyroidectomy, if needed during pregnancy, is preferentially performed in the second trimester. Conservative treatment is recommended for milder cases and is mainly restricted to hydration, with only limited evidence regarding drug treatment. Women with hypoparathyroidism can be informed that there are no major concerns regarding disease-associated infertility and that the risk of pregnancy complications is low if the disease is properly managed. Regular active surveillance is recommended, as requirements for calcium and active vitamin D may change during the course of pregnancy in either direction, with an overall trend for rather reduced doses. Any woman suffering from parathyroid disorders during pregnancy requires further surveillance in the postpartum period and during lactation, as there is an increased risk of hypercalcemia after delivery. Newborns of mothers with parathyroid diseases should, depending on disease severity, be carefully monitored for calcium levels in the first days (to weeks) after delivery since intrauterine exposure to hyper- or hypocalcemia may impact their postnatal regulation of calcium metabolism.
Sex-specific Trajectories of Insulin Resistance Markers and Reduced Renal Function During 18 Years of Follow-up: TLGS
Authors: Amouzegar Atieh , Honarvar Mohammadjavad , Masoumi Safdar , Tohidi Maryam , Mehran Ladan , Azizi Fereidoun
Published: December 2022

Context

The evidence suggest that insulin resistance (IR) complicates chronic kidney disease (CKD); however, the longitudinal association of IR with development of CKD is unknown.

Objective

This work aimed to investigate the association between the dynamic course of insulin resistance and CKD.

Methods

In the longitudinal, population-based Tehran Lipid and Glucose Study, 3071 eligible participants aged 20 years or older were followed for 18 years at 3-year intervals. Homeostatic model assessment of insulin resistance (HOMA-IR) and clinical surrogate markers of IR, including triglyceride-glucose index (TyG), visceral adiposity index (VAI), and lipid accumulation product (LAP), were calculated. Using latent variable mixture modeling, sex-specific trajectories were plotted for each IR marker. Trajectory group association of the IR markers with CKD was determined using the multivariable Cox proportional-hazards regression model.

Results

For HOMA-IR, 2 distinct trajectory patterns (stable and increasing), and for TyG, VAI, and LAP, 3 trajectories (low, moderate, and high) were identified. The participants with an increasing HOMA-IR trajectory had a significantly increased risk of CKD in men (hazard ratio [HR]: 1.72; 95% CI, 1.06-2.79) and women (HR: 1.37; 95% CI, 1.00-1.89) after adjusting for confounding variables. The high TyG and VAI trajectory classes were associated with a higher risk of CKD than the low TyG and VAI trajectory classes both in men (TyG: HR: 1.97; 95% CI, 1.12-3.46; VAI: HR:1.66; 95% CI, 1.06-2.62) and women (TyG: HR: 1.50; 95% CI, 1.06-2.12; VAI: HR:1.66; 95% CI, 1.20-2.31). In contrast, the high LAP (HR: 3.38; 95% CI, 2.08-5.48) trajectory was associated with incident CKD only in women.

Conclusion

An increasing trend of HOMA-IR is associated with a higher risk of CKD in men and women. Among clinical IR surrogate markers, abnormal trajectory patterns of LAP in women and TyG and VAI in both sexes are associated with a higher risk of CKD.
Novel Insulin-Like Growth Factor 1 Gene Mutation: Broadening of the Phenotype and Implications for Insulin Resistance
Authors: Giacomozzi Claudio , Martin Ayelen , Fernández María Celia , Gutiérrez Mariana , Iascone Maria , Domené Horacio M , Dominici Fernando P , Bergadá Ignacio , Cangiano Biagio , Persani Luca , Pennisi Patricia A
Published: December 2022

Context

Insulin-like growth factor (IGF)1 gene mutations are extremely rare causes of pre- and postnatal growth retardation. Phenotype can be heterogenous with varying degrees of neurosensory deafness, cognitive defects, glucose metabolism impairment and short stature.

Objective

This study describes a 12.6-year-old girl presenting with severe short stature and insulin resistance, but with normal hearing and neurological development at the lower limit of normal.

Methods

DNA was obtained from the proband and both parents for whole exome sequencing (WES). In silico analysis was performed to predict the impact of the IGF1 variant on IGF1 and insulin receptors (IGF1R and IR) signaling. Phosphorylation of the IGF1R at activating Tyr residues and cell proliferation analyses were used to assess the ability of each subject's IGF1 to bind and activate IGF1R.

Results

The proband had low immunoreactive IGF1 in serum and WES revealed a novel homozygous IGF1 missense variant (c.247A>T), causing a change of serine 83 for cysteine (p.Ser83Cys; p.Ser35Cys in mature peptide). The proband's parents were heterozygous for this mutation. In silico analyses indicated the pathogenic potential of the variant with electrostatic variations with the potential of hampering the interaction with the IGF1R but strengthening the binding to IR. The mutant IGF1 protein had a significantly reduced activity on in vitro bioassays.

Conclusion

We describe a novel IGF1 mutation leading to severe loss of circulating IGF1 immunoreactivity and bioactivity. In silico modeling predicts that the mutant IGF1 could interfere with IR signaling, providing a possible explanation for the severe insulin resistance observed in the patient. The absence of significant hearing and neurodevelopmental involvement in the present case is unusual and broadens the clinical spectrum of IGF1 mutations.
Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm
Authors: Lee Jin Seok , Lee Jun Sung , Yun Hyeok Jun , Kim Seok Mo , Chang Hojin , Lee Yong Sang , Chang Hang-Seok , Park Cheong Soo
Published: December 2022

Context

Tumor size is important in determining the range of surgery in papillary thyroid carcinomas (PTCs), especially those smaller than 1 cm.

Objective

We aimed to analyze the features of small PTCs with aggressive subtypes based on histological characteristics.

Methods

In this retrospective study, we reviewed the medical records of 11 570 patients with PTCs smaller than or equal to 1 cm who underwent thyroidectomy between January 2009 and December 2016. Aggressive subtypes included diffuse sclerosing, solid, tall cell, columnar cell, and hobnail subtypes.

Results

Among the 11 570 patients with PTCs smaller than or equal to 1 cm, 177 aggressive PTC subtypes were identified. Propensity score matching revealed 110 tumors (62.1%) with extrathyroidal extension of aggressive PTC subtypes and 451 (51.1%) nonaggressive PTC subtypes (95% CI, 0.41-0.80; P < .001). Metastatic central and lateral neck lymph nodes constituted 3.06 ± 3.67 and 3.81 ± 5.39 of aggressive PTC subtypes and 1.22 ± 2.14 and 2.85 ± 3.79 of nonaggressive PTC subtypes, respectively (central neck nodes: 95% CI, 1.42-2.26; P < .001; lateral neck nodes: 95% CI, 2.9-5.90; P < .001). Seven patients with aggressive PTC subtypes (3.95%) and 12 with nonaggressive PTC subtypes (1.7%) exhibited recurrence.

Conclusion

Aggressive subtypes of small PTC tumors smaller than or equal to 1 cm exhibited more extrathyroidal extension and neck node metastasis. This study suggests that surgeons should consider the aggressive subtypes as important factors when deciding the range of surgery in PTCs smaller than 1 cm.
Evolution of Nrf2 Gene Expression in HIT-T15 β-Cells During Chronic Oxidative Stress and Glucose Toxicity
Authors: Abebe Tsehay , Bogachus Lindsey , Vegaraju Adithya Krishna , Robertson R Paul
Published: December 2022

Context

Chronic exposure of pancreatic islets to elevated glucose levels causes progressive declines in beta cell Pdx-1 and insulin gene expression, and glucose-induced insulin secretion. This has been shown to be associated with excessive islet reactive oxygen species and consequent damage to beta cell function, a process termed glucose toxicity. In short-term rodent in vivo studies, Nrf2 (Kelch-like ECH-associated protein 1:nuclear factor erythroid-derived-2 related factor complex) has been shown to play a central role in defending beta cells from oxidative damage via activation of antioxidant gene expression.

Objective

The current studies were primarily designed to examine the behavior of Nrf2 gene expression during longer term exposure of beta cells to glucose toxicity.

Methods and Results

We provide evidence that gene expression of Nrf2 in HIT-T15 cells, an insulin-secreting beta-cell line, undergoes a biphasic response characterized by an initial decrease followed by increased expression during prolonged culturing of these cells in a physiologic (0.8 mM) but not a supraphysiologic (16.0 mM) glucose concentration. This was associated with a slight rise in HO-1 gene expression. Pdx-1 and insulin mRNA levels also decreased but then stabilized in late passages of cells that had been cultured in low glucose concentrations.

Conclusion

These complex events support the concept that Nrf2 gene expression plays an important regulatory role in defending beta cells during prolonged exposure to oxidative stress.
Stahlmann’s “Asian Eyes”: Jewish Identity in Peter Weiss’s The Aesthetics of Resistance, Volume 3
Authors: Rupprecht Caroline
Published: December 2022

This article focuses on the fictionalized character of the Soviet spy Richard Stahlmann, who was attributed with “Asian eyes” by Peter Weiss, in volume 3 of The Aesthetics of Resistance. In a passage that describes Stahlmann’s visit to Angkor Wat, the character’s identity crisis is precipitated by his self-Orientalizing gaze, leading him to doubt his commitment to communism. The article relates this to Weiss’s own biographical experience as a left-wing intellectual who belatedly discovered that his father was Jewish and had kept this fact a secret to evade the Nazis. However, antisemitism continued in the antifascist, anticapitalist context of both East and West Germany, as shown in The Aesthetics: Jews were portrayed as duplicitous and accused of treason, as “spies.” Weiss himself experienced leftist antisemitism and took this narrative detour to Southeast Asia to address this problem through the fictive figure of Stahlmann.
Patient loyalty to HIV care in an HIV facility in Eldoret, Kenya: A mediated mediation
Authors: Cherop Felishana , Korir Michael , Bagire Vincent , Wachira Juddy
Published: December 2022

Patient loyalty is the continuous commitment and engagement in care where patients can improve and sustain quality of life through continuous use of medical care. Identifying strengths and weaknesses in providing excellent quality care is a key measure of success of healthcare professionals and hospital management. However, few studies have examined patient loyalty from a strategic leadership perspective within HIV health care systems. The purpose of this study is to determine how patient loyalty to HIV care is influenced by multiple factors in a healthcare system environment. The study employs a mixed-methods approach guided by the complexity theory and the theory of planned behavior. A total of 444 surveys with (50 healthcare providers and 394 adult HIV-infected patients) currently on antiretroviral drugs, as well as 22 in-depth interviews with healthcare providers will be conducted. The study will be done at AMPATH Eldoret Kenya. We will use stratified proportionate and census sampling methods to select study participants for the survey while purposive and convenient sampling techniques will be used for in-depth interviews. Structured questionnaires and interviewer guides will guide data collection. Quantitative data analysis will entail hierarchical regression to test direct effects while multiple regression will test the mediation effects using the Hayes PROCESS Model No.6 in SPSS. Qualitative data analysis will be conducted using a thematic analytical method.
Predictors of unwillingness or inaccessibility to receive the COVID-19 vaccination among persons with disabilities in Bangladesh
Authors: Hossain Md Zahid , Hossain Md Akter , Al Ansary Mohammad Yaqub , Raigangar Veena , Rahman Md Habibur , Akter Ruksana , Ahmed Shameem , Jahan Sharmila , Jahid Iqbal Kabir , Hossain K. M. Amran
Published: December 2022

Introduction

Persons with disabilities (PWDs) are among the most vulnerable communities to suffer the serious consequences of COVID-19, and accepting COVID-19 vaccination is one of the recommended health advisories for them. Unwillingness to receive vaccines is a concerning issue, especially in the countries of Southeast Asia. The study aims to find out the COVID-19 vaccination rate of persons with disabilities (PWDs) in Bangladesh, the rate of unwillingness or inaccessibility of vaccination for PWDs, and predict the possible reasons for unwillingness.

Methods

A descriptive cross-sectional survey of PWDs aged 12 years or more was conducted in 12 rehabilitation centers in Bangladesh between February 2022 and May 2022. A self-developed structured questionnaire on socio-demographic, disability, and health indicators, acceptance and accessibility of COVID-19 vaccines, and knowledge and attitude towards vaccination was used for the survey. The study has been conducted according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for a cross-sectional survey.

Results

With a 69% response rate, 241 PWDs participated in the study. PWDs with a spinal cord injury were the major respondents (62.7%). A total of 186 (77.2%) PWDs had taken one or more doses of COVID-19 vaccines of three doses supplied, and 55 (22.8%) were unwilling to have a vaccination. All vaccine recipients reported good accessibility to vaccination booths. The predictive factors of unwillingness were spinal cord injury type of disability (OR .36, P<.01), people coming to the rehabilitation center from rural areas (OR .44, P<.01), poor knowledge of COVID-19 vaccination (OR .78, P<.01), and dependency on mobility (OR.24, P<.001).

Conclusion

More than one-fifth of the persons with disabilities aged between 12 and 80 years were unwilling to receive the COVID-19 vaccination despite the accessibility of information and availability of the COVID-19 vaccine, mainly due to poor knowledge and mobility issues.
Rapid molecular assays for the detection of the four dengue viruses in infected mosquitoes
Authors: Ahmed Madeeha , Pollak Nina M. , Hugo Leon E. , van den Hurk Andrew F. , Hobson-Peters Jody , Macdonald Joanne
Published: December 2022

The pantropic emergence of severe dengue disease can partly be attributed to the co-circulation of different dengue viruses (DENVs) in the same geographical location. Effective monitoring for circulation of each of the four DENVs is critical to inform disease mitigation strategies. In low resource settings, this can be effectively achieved by utilizing inexpensive, rapid, sensitive and specific assays to detect viruses in mosquito populations. In this study, we developed four rapid DENV tests with direct applicability for low-resource virus surveillance in mosquitoes. The test protocols utilize a novel sample preparation step, a single-temperature isothermal amplification, and a simple lateral flow detection. Analytical sensitivity testing demonstrated tests could detect down to 1,000 copies/µL of virus-specific DENV RNA, and analytical specificity testing indicated tests were highly specific for their respective virus, and did not detect closely related flaviviruses. All four DENV tests showed excellent diagnostic specificity and sensitivity when used for detection of both individually infected mosquitoes and infected mosquitoes in pools of uninfected mosquitoes. With individually infected mosquitoes, the rapid DENV-1, -2 and -3 tests showed 100% diagnostic sensitivity (95% CI = 69% to 100%, n=8 for DENV-1; n=10 for DENV 2,3) and the DENV-4 test showed 92% diagnostic sensitivity (CI: 62% to 100%, n=12) along with 100% diagnostic specificity (CI: 48–100%) for all four tests. Testing infected mosquito pools, the rapid DENV-2, -3 and -4 tests showed 100% diagnostic sensitivity (95% CI = 69% to 100%, n=10) and the DENV-1 test showed 90% diagnostic sensitivity (55.50% to 99.75%, n=10) together with 100% diagnostic specificity (CI: 48–100%). Our tests reduce the operational time required to perform mosquito infection status surveillance testing from > two hours to only 35 minutes, and have potential to improve accessibility of mosquito screening, improving monitoring and control strategies in low-income countries most affected by dengue outbreaks.
Reduction of mineralizing activity of periodontal bone tissue in rats with consumption of ordinary sunflower oil
Authors: Levitsky A. , Pupin T. , Selivanskaya I. , Lapinskaya A. , Markov A.
Published: December 2022

More than 20 % of people over the age of 50 suffer from osteoporosis.  Lipids play an important role in the pathogenesis of osteoporosis.

Background. To investigate the effect of ordinary (high-linoleic) sunflower oil (OSO) on the state of periodontal bone tissue.

Methods. In 5 series of experiments, determine the mineralization activity of the alveolar appendix of the mandible rats that were obtained with feed 5 or 15 percent of OSO for from 22 to 75 days. Mineralizing activity was determined by the ratio of activity of alkaline and acid phosphatase. In liver lipids (fractions of phospholipids and free fatty acids) were determined by the content of long-chain polyunsaturated fatty acids (LCPUFA) by the gas chromatographic method.

Results. A decrease in mineralizing activity in OSO consumption, especially when using a feed with 15 % of OSO against a dysbiosis or metabolic syndrome. A significant (almost 10 times) is shown to reduce the content of ω-3 PUFA in fraction of phospholipids of the liver of rats receiving a diet with a content of OSO.

Conclusion. Sunflower oil reduces the mineralizing activity of periodontal bone tissue by reducing the endogenous biosynthesis of ω-3 PUFA.
Blood biochemistry and stress biomarkers of broiler chickens supplemented with different levels of Yucca schidigera saponins reared under tropical conditions
Authors:   Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Selangor, Malaysia, Mohamed M. Alghirani , Chung Eric Lim Teik ,   Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Selangor, Malaysia,   Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 Selangor, Malaysia, Kassim Nafeesa Abu ,   Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 Selangor, Malaysia, Ong Yee Lyn ,   Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 Selangor, Malaysia, Jesse Faez Firdaus Abdullah ,   Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 Selangor, Malaysia,   Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Selangor, Malaysia, Sazili Awis Qurni ,   Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Selangor, Malaysia, Loh Teck Chwen ,   Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Selangor, Malaysia
Published: December 2022

The primary goal of this study was to determine the impacts of supplementing varying amounts of Y. schidigera saponins on the blood biochemistry and stress biomarkers of broiler chickens raised in tropical settings. A total of 300 male day-old Ross 308 broilers were randomly assigned to six treatment groups. Treatment 1 broiler chickens were fed commercial diets with no added additives, whereas treatment 2 broiler chickens were offered commercial diets containing 100 mg/kg of the antibiotic oxytetracycline. Treatments 3, 4, 5, and 6 broiler chickens received similar commercial diets supplemented with 25, 50, 75, and 100 mg/kg of powdered Y. Shidigera saponins, respectively, without antibiotics. On day 42, six broilers from each treatment were randomly selected, slaughtered, and blood samples were collected for serum lipid profile, liver function,acute phase proteins, hormone, and heat shock protein analyses. There were notable changes (P < 0.05) in the serum lipid profile, acute phase proteins, hormone, and heat shock protein among treatments. Broilers treated with 100 mg/kg of Y.Shidigera saponins in T6 showed the lowest levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol concentrations while having the highest high-density lipoprotein cholesterol level without affecting the liver parameters. Moreover, the serum amyloid A, alpha-1-acid glycoprotein, corticosterone, and heat shock protein 70 concentrations were also the lowest as compared to the other treatments. In conclusion, supplementing 100 mg/kg of Y. Shidigera saponins in broiler diets could improve lipid profiles and act as an anti-stress for commercial broilers raised in tropical regions.
A LÓGICA DA PESQUISA CIENTÍFICA DE KARL POPPER
Authors: Silveira Penha Patrícia
Published: December 2022

Karl R. Popper (1902-1994), foi um filósofo austríaco, um dos maiores pensadores do século XX, que realizou diversos artigos e obras a respeito do problema do conhecimento científico, examinando conceitos de cunho metafísico, como por exemplo o tempo, a teoria da evolução e a problemática da demarcação como um critério científico. O objetivo do presente trabalho é apresentar a concepção de ciência, bem como o problema da demarcação e da falseabilidade fundamentados no método popperiano do racionalismo crítico, a partir de um breve estudo do primeiro capítulo da Lógica da Pesquisa Científica (1934). Portanto, na perspectiva de Popper, o caráter científico consiste em demonstrar a possibilidade da aplicação do critério da falseabilidade como um método fundamental para o saber científico.
CONTRIBUTO DA TEORIA RICOEURIANA DA TRÍPLICE MIMESE PARA UMA CONCEPÇÃO SEMÂNTICA DA IMAGINACÃO
Authors: CUNHA WANDERLEY
Published: December 2022

Temps et Récit é uma obra imprescindível para a compreensão do projeto filosófico de Paul Ricoeur, dado que ela funciona indubitavelmente como uma espécie de dobradiça no conjunto da produção intelectual desenvolvida pelo filósofo francês, pois, por um lado, através da noção de ‘inovação semântica’, se articula à perspectiva poética desenvolvida em La Méthaphore vive  e, por outro, por meio da noção de ‘identidade narrativa’ se articula à perspectiva prática desenvolvida em Soi-meme comme un autre. Assim sendo, este artigo se propõe a efetuar uma introdução à leitura de Temps et Récit a partir de sua articulação com a concepção semântica da imaginação elaborada por Ricoeur em seus estudos sobre os enunciados metafóricos. Para tanto, empreende-se uma análise do modelo de articulação entre a experiência aporética do tempo e a inteligibilidade narrativa que Ricoeur denomina de ‘tríplice mimese’, com o intuito de se evidenciar as especificidades do funcionamento da imaginação semântica no domínio da narrativa.
SOBRE A QUERELA DA METÁFORA ENTRE PAUL RICŒUR E JACQUES DERRIDA
Authors: Amancio Felipe
Published: December 2022

Resumo: este artigo tem por objetivo relatar a chamada “querela da metáfora” entre Paul Ricoeur e Jacques Derrida. A partir do comentário dos três textos que formam o corpus dessa discussão: “A mitologia branca”, “A metáfora viva”, e Le retrait de la métaphore, propõe-se uma análise dos pressupostos filosóficos desses autores que visa ressaltar suas diferenças de abordagem ao invés de simular um precário acordo, de modo a endossar o argumento, segundo o qual, ambos seguem direções opostas sobre o que se presume a mesma questão.   

Palavras-chave: desconstrução, hermenêutica, Jacques Derrida, metáfora, Paul Ricoeur.

Abstract: This article aims to report the so-called “metaphor quarrel” between Paul Ricoeur and Jacques Derrida. Based on the commentary of the three texts that forms the corpus of this discussion: “The White Mythology”, “The Living Metaphor”, and Le retrait de la métaphore, an analysis of the philosophical assumptions of these authors is proposed, aiming to highlight their differences in approach instead of simulating a precarious agreement, in order to endorse the argument, according to which, they both follow opposite directions on what is assumed to be the same issue.

Keywords: deconstruction, hemeneutics, Jacques Derrida, metaphor, Paul Ricoeur.
O CÍRCULO HERMENÊUTICO DE PAUL RICŒUR COMO MEDIAÇÃO NARRATIVA DA EXPERIÊNCIA
Authors: Dias Bubols Carlos Frederiqui
Published: December 2022

Este trabalho pretende sumarizar as múltiplas mediações da experiência no pensamento de Paul Ricœur, tendo como diretriz sua noção de círculo hermenêutico como encadeamento dos três momentos miméticos ― mímesis I, mímesis II e mímesis III ―, a fim de fazer frente às noções de compreensão de si em que o ego é conhecido diretamente pelos sujeitos por introspecção. Distintamente de filósofos de filiação fenomenológica, tais como Edmund Husserl, para quem o ego transcendental pode ser encontrado mediante a realização da epoché, ou Jean-Paul Sartre, para quem o ego é um objeto transcendente de uma consciência impessoal mais primitiva que chamou de consciência pré-reflexiva, para Ricœur, entretanto, o ego não pode ser plenamente alcançado reflexivamente, senão por um movimento hermenêutico mais extenso que passa pela interpretação de diversas camadas simbólicas e culturais.
“LA PAROLE EST MON ROYAUME”
Authors: Lima Barros de Oliveira Rafael
Published: December 2022

Neste artigo, procuro reconstruir a filosofia da linguagem de Paul Ricœur. A partir da concepção de linguagem como tripla mediação, exposta no artigo “Philosophie et langage”, exponho a maneira como o autor constrói sua perspectiva sobre o fenômeno linguístico a partir de um diálogo intenso com outras disciplinas científicas e outros campos do saber. Para Ricœur, a tarefa da filosofia com vistas à linguagem consiste em reabrir o caminho – bloqueado pela linguística e pela constituição da linguagem enquanto objeto científico – da linguagem como mediação do sujeito ao mundo, do sujeito a outrem e do sujeito a si mesmo. Adicionalmente, exponho três momentos-chave de reelaboração dessa tripla mediação, a saber: o conflito das interpretações, o modelo do texto e a identidade narrativa. Com isso, trata-se de situar as reflexões de Ricœur nesse campo no qual elas raramente se veem incluídas: a filosofia da linguagem.
BEM-VIVER RICOEURIANO E A SUA RELEVÂNCIA CONTEMPORÂNEA
Authors: Nobre José Aguiar
Published: December 2022

O pensamento de Paul Ricoeur para a contemporaneidade alcança uma relevância ímpar dada a sua relevância e riqueza no sinuoso processo da formação humana integral com pretensões de universalidade. Ricoeur, ao longo de sua trajetória intelectual e contribuição filosófico-teológica, possibilitou uma compreensão de que o ser humano que se pretenda feliz ou realizado deverá se colocar sempre no processo de aprendizagem. Do ponto de vista formal indagamos: qual a relevância do pensamento acerca do bem-viver ricoeuriano para a sociedade contemporânea? A metodologia de pesquisa se circunscreve à revisão bibliográfica em cuja obra ricoeuriana sobre o desejo de vida boa tem o seu assento e delimitação. Os resultados esperados circunscrevem à compreensão de que, em face de uma sociedade demasiadamente egoísta e desigual como a que vivemos, quanto mais refletirmos sobre a necessidade de adotarmos um novo estilo de vida rumo à educação para o coletivo, tanto maiores chances de evoluirmos neste quesito teremos.
O INGRESSAR DA LIGAÇÃO NA MORADA DA HABITAÇÃO
Authors: Teixeira Santos Rafael
Published: December 2022

No presente artigo pretendemos investigar a constituição do “habitar” de Martin Heidegger – apresentado em seu ensaio Construir, Habitar, Pensar – na essência da ligação, segundo um encontro crítico com o ensaio Ponte e Porta de Georg Simmel. Faz-se a pergunta: como se condicionam habitação e ligação? Seguimos Heidegger que apresenta o habitar como uma demora junto às coisas. O caráter de coisa da coisa é aqui estruturado pela quadratura, modo que tem a coisa como reunião integradora. A potência da ligação já retorna neste modo de ver a coisa. A ponte, como coisa própria e reunião integradora, carrega por sua ligação o destino do pensamento sobre os homens e coisas.
ENTREVISTA REDE BRASIL-RICOEUR
Authors: Freitas  Pinto Weiny César , Cristaldo Silva Pedro Henrique , Nascimento Fernando , Salles Walter , Reichert do Nascimento Cláudio , Viana Cristina
Published: December 2022

Entrevista sobre a história de criação e desenvolvimento do Grupo online de leitura da obra de Paul Ricoeur, grupo do qual surgiu, em 2022, a Rede Brasil-Ricoeur - Associação Brasileira de Estudos Ricœurianos. A entrevista foi realizada com os idealizadores e com os primeiros coordenadores do Grupo, em maio deste ano, por meio de reunião online, posteriormente transcrita e editada pelos entrevistadores, e finalmente revisada com acréscimos editoriais pelos entrevistados.

Em anexo à entrevista, o leitor encontrará uma Cronologia de fatos e eventos relativos aos estudos de Ricoeur no Brasil.
Prohibition as a method of struggle against anti-Ukrainian films
Authors: Sokolova Sofiia
Published: December 2022

Purpose. This study aims to reveal the experience of Ukraine in banning as a method of struggle against Russian propagandist anti-Ukrainian films.

Methods. Deduction technique as a process of logical concluding based on the complex of analyzed facts as well as summarizing have been applied.

Results. Cinematographic informational aggression of Russia against Ukraine began in 2000 with the coming to power of V. Putin. Taking into consideration the fact, that it is television which is the most popular source of information for the absolute majority of Russians it can be claimed that Russian propagandistic films, which are very products of Putin’s policy, played not the last role in inciting aggression among Russian population.

Discussion. Since 2000 Russian cinema production has started to actively focus on popularization of their own power structures and producing films propagating war, aiming at inciting of inter-ethnical, religious aggression, humiliation of Ukrainian nation, humiliation of an individual etc. the films have been heating up Russian’s aggression against Ukrainians and preparing Russia’s population for the war with Ukraine. These films possess great potential to form mythological thinking and stereotyping of viewers’ views.

Practice has proved that introducing prohibitions as a method of struggle against anti-Ukrainian propagandist films is quite an effective method of defense.
Application features of educational quests in the format of blended learning in higher educational establishments
Authors: Ulishchenko Violetta , Ulishchenko Andriy , Kefeli-Yanovska Olena
Published: December 2022

In the process of work with students (post-graduate students, interns, teachers), the application of interactive forms of work has proven its effectiveness and relevance. At the same time, we should expand the methodological diversity of the interactive, involve such forms of work that best as possible meet the needs of the blended learning format.

Quest as an interactive technology has many advantages – from a collective goal setting, definition of a strategy of movement to coordinated performance of intermediate tasks, search for substantiations and presentation of a collective decision. The main thing is that there are no obstacles to the realization of the educational quest, such as online or offline, because the help comes from the interactive board Miro.

The purpose of the work is to substantiate the peculiarities of the application of the educational quest as a game technology in blended and distance education with the goal of deepening the motivation of students of higher education institutions of Ukraine, in particular medical ones; to intensify scientific research activities, to improve interaction in groups and teams, to promote the development of clinical thinking and communicative competence.

Research methods. Theoretical (processing of the source base) and empirical (development and implementation of didactic quests in educational activities) research methods were used in the work. Due to the combination of these components, the expediency of application of quest-technologies in a blended form of education in higher education institutions is substantiated.

Conclusions. Thanks to the involvement of quests, those who study will not only save motivation, but they will also structure, renew, update the acquired knowledge for further professional growth.

Quests do not require students to be physically present in the classroom, and under the condition of a proper organization (script, route sheets for teams), the final result of their conducting in the format of blended education (through ZOOM, MIRO, another online platform for group work) is quite high.

It is also interesting to note that quests in the form close to the competition, provide the opportunity to carry out summative and formative assessment, which is extremely important for monitoring the quality of knowledge.

The application of educational quests in higher medical education with the involvement of interactive online boards opens up the opportunity to provide active interaction of subjects of training in conditions of a blended format.

During the quest, the teacher performs the functions of a moderator, since organizational moments and the working atmosphere during group communication depend on him, as well as possible help in the form of vector direction (if the discussion has reached a dead end), and substantiation of the final results.
Low-wavenumber compensation with Zernike tilt for non-Kolmogorov turbulence phase screens
Authors: Wijerathna Erandi , Zhan Hanyu , Voelz David , Muschinski Andreas
Published: December 2022

The fast-Fourier-transform-based filtering method for phase screen
generation remains popular for numerical simulation of optical
propagation through turbulence; however, these screens inherently
underrepresent the spectral density at low wavenumbers. Here, the
“Z-tilt” approach is explored to augment the spectral density at low
wavenumbers by adding a random phase tilt, which is derived from the
wavefront phase statistics of a Zernike polynomial basis. This
approach is computationally efficient and can be applied to any
statistically homogeneous and isotropic refractive index field. An
analytic result is provided for the von Kármán spectrum with finite
outer scale. In a quantitative comparison with phase screens
compensated for using a common subharmonic approach, the Z-tilt method
shows the best agreement with the analytical structure function when
the outer scale is greater than about three times the screen
dimension. For outer scales of the order of the screen dimension, the
subharmonic and a modified Z-tilt method give the most accurate
results. A propagation simulation demonstrates that the
aperture-averaged angle-of-arrival variance is accurately predicted
using the Z-tilt method.
Reduction of nanoparticles in optical thin films through ion etching
Authors: McCauley Joshua , Jupé Marco , Zhang Jinlong , Wienke Andreas , Ristau Detlev
Published: December 2022

Contaminating particles in optical thin films can lead to the formation
of nodules and reduction of laser induced damage threshold (LIDT).
This work investigates the suitability of ion etching of the
substrates to reduce the impact of nanoparticles. Initial
investigations suggest that ion etching can remove nanoparticles from
the sample surface; however, doing so introduces texturing to the
surface of the substrate. This texturing leads to an increase in
optical scattering loss, though LIDT measurements show no significant
reduction in the durability of the substrate.
Advantages of holographic imaging through fog
Authors: Gröger Alexander , Pedrini Giancarlo , Claus Daniel , Alekseenko Igor , Gloeckler Felix , Reichelt Stephan
Published: December 2022

In this paper, we demonstrate digital holographic imaging through a 27-m-long fog tube filled with ultrasonically generated fog. Its high sensitivity makes holography a powerful technology for imaging through scattering media. With our large-scale experiments, we investigate the potential of holographic imaging for road traffic applications, where autonomous driving vehicles require reliable environmental perception in all weather conditions. We compare single-shot off-axis digital holography to conventional imaging (with coherent illumination) and show that holographic imaging requires 30 times less illumination power for the same imaging range. Our work includes signal-to-noise ratio considerations, a simulation model, and quantitative statements on the influence of various physical parameters on the imaging range.
Excited oxygen kinetics at electronvolt temperatures via 5-MHz RF-diplexed laser absorption spectroscopy
Authors: Minesi Nicolas Q. , Nair Anil P. , Richmond Miles O. , Kuenning Nicholas M. , Jelloian Christopher C. , Spearrin R. Mitchell
Published: December 2022

A multi-MHz laser absorption sensor at 777.2 nm (

12

,

863

c
m

−
1

) is developed for simultaneous
sensing of (1) 

O

(
5

S

0

)

number density, (2) electron
number density, and (3) translational temperature at conditions
relevant to high-speed entry conditions and molecular dissociation.
This sensor leverages a bias tee circuit with a distributed feedback
diode laser and an optimization of the laser current modulation
waveform to enable temporal resolution of sub-microsecond kinetics at
electronvolt temperatures. In shock-heated

O

2

, the precision of the temperature
measurement is tested at 5 MHz and is found to be within

±

5

%

from 6000 to 12,000 K at
pressures from 0.1 to 1 atm. The present sensor is also
demonstrated in a CO:Ar mixture, in parallel with a diagnostic for CO
rovibrational temperature, providing an additional validation across
7500–9700 K during molecular dissociation. A
demonstration of the electron number density measurement near
11,000 K is performed and compared to a simplified model of
ionization. Finally, as an illustration of the utility of this
high-speed diagnostic, the measurement of the heavy particle
excitation rate of

O

(
5

S

0

)

is extended beyond the temperatures
available in the literature and is found to be well represented by

k

(
3

P

→
5

S
0

)
=
2.7
×

10

−
14

T

0.5

exp
⁡
(
−
1.428
×

10
4

/

T
)

c
m

3

⋅

s

−
1

from 5400 to 12,200 K.
Grain size characterization of Ti-6Al-4V titanium alloy based on laser ultrasonic random forest regression
Authors: Zhang Juhao , Wu Jinfeng , Yin Anmin , Xu Zhi , Zhang Zewen , Yu Huihui , Lu Yujie , Liao Wenchao , Zheng Lei
Published: December 2022

In this paper, a random forest regression (RFR) rain size characterization method based on a laser ultrasound technique is investigated to predict the grain size of titanium alloy (Ti-6Al-4V). The longitudinal wave velocity of the ultrasound signal and the attenuation coefficient at different frequencies are used as the input and the grain size is used as the output. An RFR algorithm was used to develop a grain size prediction model. Meanwhile, the grain size calculation model based on conventional scattering attenuation was established by calibrating the

n

value in the classical scattering theory using the attenuation coefficients at different frequencies of ultrasonic signals. The results show that the RFR algorithm is feasible for the grain size characterization of titanium alloys.
Optical single-channel color image encryption based on chaotic fingerprint phase mask and diffractive imaging
Authors: Wang Yonghui , Zhao Qinyu , Zhang Haoran , Li Tianlun , Xu Wenjun , Liu Shuaiqi , Su Yonggang
Published: December 2022

An optical single-channel color image encryption scheme based on chaotic fingerprint phase mask and diffractive imaging is proposed. In this proposed encryption scheme, the fingerprint used to generate the random phase masks is served as a secret key directly. Additionally, the random phase masks generated by the fingerprint, chaotic Lozi map, and secure hash algorithm (SHA-256) are used only as interim variables. With the help of the chaotic fingerprint phase masks placed at different diffraction distances, the color image that is encoded into a grayscale pattern by the phase-truncation technique is encrypted into a noise-like diffraction pattern. For decryption, the color image can be retrieved from the noise-like diffraction pattern by using an iterative phase retrieval algorithm, fingerprint, and phase keys generated from the encryption process. Since the fingerprint key shared by the sender and authorized receiver is strongly linked with the user and does not need to be transmitted over the open network, the security of this proposed encryption scheme can be greatly improved. Additionally, the parameters of the chaotic Lozi map and Fresnel diffraction distances can also provide additional security to the proposed encryption scheme. Furthermore, compared with the encryption schemes based on digital holography, the implementation of this proposed encryption scheme is relatively simple. The numerical simulations and analysis verify the feasibility, security, and robustness of this proposed encryption scheme.
Rotating anisotropic rectangular hollow Gaussian array
Authors: Liu Jinfu , Feng Ying , Ji Xiaoling , Wu Hao , Wang Tao
Published: December 2022

A new class of partially coherent sources that can produce stable rotating anisotropic rectangular hollow Gaussian array profiles in the far field is presented. The cross-spectral density function and the spectral density of this kind of source on the propagation are derived, and its propagation characteristics, which are quite different from twisted Gaussian Schell-model beams, are discussed. The results show that each hollow lobe in the array tends to rotate around the axis during propagation. In addition, the dimension of the array, the distance between the lobes of the array, and the number of rows and columns of the rectangular array can be flexibly manipulated by adjusting the source parameters. Our work may provide a method to generate rotating anisotropic array beams with hollow lobes, which could have certain reference values in optical manipulation.
Fourier-transform infrared photoreflectance spectroscopy of the InSb/InAs/In(Ga,Al)As/GaAs metamorphic heterostructures with a superlattice waveguide
Authors: Firsov D. D. , Luferau A. I. , Kolyada D. V. , Chernov M. Yu. , Solov’ev V. A. , Andreev A. D. , Komkov O. S.
Published: December 2022

Fourier-transform infrared photoreflectance (PR) spectroscopy was used to study the energy spectrum of InSb/InAs/In(Ga,Al)As/GaAs metamorphic heterostructures with a superlattice waveguide at room temperature (RT). Theoretical calculations in the framework of the eight-band Kane model were performed to obtain a reliable knowledge of the actual energies of the most probable optical transitions. The experimental results were analyzed to determine the influence of the design features and stress balance on the energy spectra of the structures. Photoluminescence studies performed at 11 K and RT, as well as the determination of the internal quantum efficiency of luminescence, enabled us to characterize the emission characteristics of the structures, regardless of their waveguide efficiency. The structure with a 5-nm-thick GaAs insertion within the metamorphic buffer layer exhibited the highest probability of the main optical transition observed in the PR spectra as well as the highest luminescence intensity and quantum efficiency.
Snapshot hyperspectral imaging with quantum correlated photons
Authors: Zhang Yingwen , England Duncan , Sussman Benjamin
Published: December 2022

Hyperspectral imaging (HSI) has a wide range of applications from environmental monitoring to biotechnology. Conventional snapshot HSI techniques generally require a trade-off between spatial and spectral resolution and are thus limited in their ability to achieve high resolutions in both simultaneously. Most techniques are also resource inefficient with most of the photons lost through spectral filtering. Here, we demonstrate a proof-of-principle snapshot HSI technique utilizing the strong spectro-temporal correlations inherent in entangled photons using a modified quantum ghost spectroscopy system, where the target is directly imaged with one photon and the spectral information gained through ghost spectroscopy from the partner photon. As only a few rows of pixels near the edge of the camera are used for the spectrometer, effectively no spatial resolution is sacrificed for spectral. Also since no spectral filtering is required, all photons contribute to the HSI process making the technique much more resource efficient.