bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacological Screening of Species from the Lippia genus, Content in Terpenes
and Phenylpropanoids, and their Vasorelaxing Effects on Human Umbilical
Artery
Authors: de Menezes Dantas Debora , Pereira-de-Morais Luís , de Alencar Silva Andressa , da Silva Renata Evaristo Rodrigues , Dias Francisco Junio , de Sousa Amorim Thais , Cruz-Martins Natália , Melo Coutinho Henrique Douglas , Barbosa Roseli
Published: November 2022

Background:

Naturally occurring bioactive compounds have a plethora of biological effects.

Objective:

In this study, we examined a pharmacological screening of natural products on the human umbilical
artery (HUA).

Methods:

HUA preparations were used to follow contractions by KCl (60 mM) and tested at different concentrations
(1-5000 μg/mL and μM) of the Lippia alba (EOLa) and Lippia origanoides (EOLo) essential oils, terpenes
(citral, limonene perilic alcohol) and phenylpropanoids (eugenol, methyl eugenol).

Results:

The reduction corresponded to approximately 100%, except for limonene (80 ± 1.2%). When evaluating
the concentration of the natural product that promotes 50% relaxation of the HUA contracted by KCL, EC50
values were: 424.3 μg/mL (EOLa); 468.7 ± 6.7 μg/mL (EOLo); 264.2 ± 8.2 μM (citral); 677.8 ± 5.4 μM (limonene);
186.3 ± 6.4 μM (peryl alcohol); 986.4 ± 7.9 μM (eugenol); and 279.1 ± 4.4 μM (methyl-eugenol). Perillyl
alcohol had a lower EC50 (consequently it has a higher pharmacological potency).

Conclusion:

The plant extracts have a promising vasorelaxing effect in HUAs, paving the way for future investigations:
as applications in diseases related to these vessels, such as preeclampsia.
Electrochemical Sensor Design Based on Silver Nanoparticles Modified
Multiwalled Carbon Nanotubes Paste Electrode for the Sensitive Determination
of Mepivacaine
Authors: Demir Ersin , Silah Hülya , Erkmen Cem , Uslu Bengi
Published: November 2022

Mepivacaine, an amide-type local anesthetic drug widely used in regional anesthesia,
was studied by some aspects such as electrochemical behavior, mechanism illumination, and analytical
applications by cyclic voltammetry (CV) and different pulse voltammetry (DPV) methods.
In this study, a novel, fast, simple, portable, and the inexpensive electrochemical sensor was developed
for the determination of mepivacaine. This study was carried out by mepivacaine anodic direction
detection for the first time. The modified sensor was fabricated with silver nanoparticles
(AgNP) and multiwalled carbon nanotubes paste electrode (MWCNTPE) by using the drop-dry
method. Different experimental parameters, such as pulse amplitude, step potential, and scanning
rate in the DPV application module, were optimized. Under optimal operation conditions, the limit
of detection (LOD) as low as 31 μg L-1 was found over the dynamic range (0.1–8.0 mg L-1). In
contrast to its high response towards mepivacaine, the DPV exhibits negligible responses on modified
AgNP/MWCNTPE when exposed to interfering species such as dopamine, uric acid, glucose,
ascorbic acid, and some heavy metals. Exceptionally, the proposed DPV method on modified
AgNP/MWCNTPE was successfully applied to pharmaceutical dosage form and synthetic human
serum with a low relative standard deviation (RSD) of 1.35% and 2.02%, respectively.
Study on Cellular Localization of Bin Toxin and its Apoptosis-inducing
Effect on Human Nasopharyngeal Carcinoma Cells
Authors: Boonserm Panadda , Kanwal Simab
Published: November 2022

Background:

Bacterial pore-forming toxins, BinA and BinB together known as the binary
toxin are potent insecticidal proteins, that share structural homology with antitumor bacterial
parasporin-2 protein. The underlying molecular mechanism of Bin toxin-induced cancer cell cytotoxicity
requires more knowledge to understand whether the toxin induced human cytotoxic effects occur
in the same way as that of parasporin-2 or not.

Methods:

In this study, anticancer properties of Lysinibacillus sphaericus derived Bin toxin on HK1
were evaluated through MTT assay, morphological analysis and lactate dehydrogenase efflux assay.
Induction of apoptosis was determined from RT-qPCR, caspase activity and cytochrome c release assay.
Internalization pattern of Bin toxin in HK1 cells was studied by confocal laser-scanning microscopic
analysis.

Results:

Activated Bin toxin had strong cytocidal activity to HK1 cancer cell line at 24 h postinoculation.
Both BinA and BinB treated HK1 cells showed significant inhibition of cell viability at
12 μM. Induction of apoptotic mediators from RT-qPCR and caspase activity analyses indicated the
activation of programmed cell death in HK1 cells in response to Bin toxin treatment. Internalization
pattern of Bin toxin studied by using confocal microscopy indicated the localization of BinA on cell
surface and internalization of BinB in the cytoplasm of cancer cells as well as colocalization of BinA
with BinB. Evaluation of cytochrome c release also showed the association of BinB and BinA+BinB
with mitochondria.

Conclusions:

Bin toxin is a cytotoxic protein that induces cytotoxic and apoptotic events in HK1
cells, and may have high therapeutic potential as an anti-cancer agent.
Integrating Bioinformatics and Network Pharmacology to Explore
the Therapeutic Target and Molecular Mechanisms of Schisandrin on
Hypertrophic Cardiomyopathy
Authors: Shen Chaozhuang , Shen Pingping , Wang Xiaohu , Wang Xingwen , Shao Wenxin , Geng Kuo , Xie Haitang
Published: November 2022

Background:

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and is currently the leading cause of sudden death in adolescent athletes. Schisandrin is a quality marker of the traditional Chinese medicine Schisandra chinen-sis, which has an excellent therapeutic effect on HCM, but its pharmacological mecha-nism remains unclear.

Objective:

This study aimed to explore the potential and provide scientific evidence for schisandrin as a lead compound against hypertrophic cardiomyopathy.

Methods:

The drug-like properties of schisandrin were predicted using the Swis-sADME website. Then, the PharmMapper database was used to predict potential drug targets and match gene names in the Uniprot database. HCM targets were collected from NCBI, OMIM, and Genecards databases and intersected with drug targets. The intersection targets were imported into the STRING database for PPI analysis, and core targets were identified. KEGG and GO enrichment analysis was performed on the core targets through the DAVID database, and all network maps were imported into Cyto-scape software for visualization optimization. HCM-related datasets were downloaded from the GEO database to analyze core targets and screen differentially expressed target genes for molecular docking.

Results:

After the PPI network analysis of the intersection targets of drugs and diseases, 12 core
targets were screened out. The KEGG analysis results showed that they were mainly involved in
Rap1, TNF, FoxO, PI3K-Akt, and other signaling pathways. After differential analysis, PPARG,
EGFR, and MMP3 targets were also screened. The molecular docking results showed that schisandrin
was well bound to the protein backbone of each target.

Conclusion:

This study used network pharmacology combined with differential expres-sion and molecular docking to predict that schisandrin may treat HCM by acting on PPARG, EGFR, and MMP3 targets, and the regulatory process may involve signaling pathways, such as Rap1, TNF, FoxO, and PI3K-Akt, which may provide a valuable reference for subsequent studies.
Analysis Queues at Counters for Outpatients in the Regional Public Hospital of Makassar Indonesia
Authors: Alim Andi , Arwan Arwan , Gafur Abdul , Badwi Adam
Published: November 2022

Background:

The queue is something that many consumers or customers encounter. Many consumers or customers complain about the long queue, but there are also customers who are satisfied with a company service that is so fast without having to queue too long.

Objective:

This study aims to determine the service time, file completeness, and service facilities for the Queuing Analysis at the Regional Public Hospital of Makassar City, South Sulawesi.

Methods:

This type of research is analytic research with cross-sectional design and the total sample is 185 people.

Results:

This study found that there was a relationship between service time and queue analysis at the counters of Regional Public Hospital of Makassar City (p = 0.000), there was a relationship between file completeness and queuing analysis at the counters of Regional Public Hospital of Makassar City (p = 0.004), there was a relationship with service facilities. on the analysis of queues at the counters of Regional Public Hospital of Makassar City (p = 0.000).

Conclusion:

Based on the findings above, health workers should provide good service to outpatients so as not to make patients complain about long queues and to improve the quality of health services at the Regional Public Hospital of Makassar City.
Canada's Energy Security in the Context of Global Instability
Authors: Tertzakian Peter
Published: November 2022

On August 18, 2022, the Canadian Association for Security and Intelligence Studies (CASIS)-Vancouver hosted a Digital Roundtable titled Canada's Energy Security in the Context of Global Instability. This event was conducted by Peter Tertzakian, Deputy Director of the ARC Energy Research Institute. Mr. Tertzakian’s presentation was followed by a moderated question-and-answer period in which the audience was able to deepen their understanding of the topic. The discussion centred around the dependency that societies have on energy, how countries have managed to cover their energy demands, and its effects on the geopolitical landscape.
OVID-19 Disease Detection Based on Machine Learning and Chest X-Ray Images
Authors: Teimoor Ramyar Abdulrahman , Mohammed Mihran Abdulrahim
Published: November 2022

Due to increasing population, automated illness identification has become a critical problem in medical research. An automated illness detection framework aids physicians in disease diagnosis by providing precise, consistent, and quick findings, as well as lowering the mortality rate. Coronavirus (COVID-19) has expanded worldwide and is now one of the most severe and acute disorders. To avoid COVID-19 from spreading, making an automatic detection system based on X-ray chest pictures ought to be the quickest diagnostic alternative. The goal of this research is to come up with the best model for detecting COVID-19 diagnosis with the greatest accuracy. Therefore, four models, Convolutional Neural Networks, Residual Network 50, Visual Geometry Group 16 (VGG16), and VGG19, have been evaluated using the same images preprocessing method. In this study, performance metrics include accuracy, precision, recall, and F1 scores are used for evaluating proposed method. According to our findings, the VGG16 model is a viable candidate for detecting COVID-19 instances, because it has highest accuracy; in result overall accuracy of 98.44% in training phase, 98.05% invalidation phase and 96.05% in testing phase is obtained. The results of other performance measurements are shown in the result section, demonstrating that the majority of the approaches are more than 90% accurate. Based on these results, radiologists may find the proposed VGG16 model to be an intriguing and a helpful tool for detecting and diagnosing COVID-19 patients quickly.
Personalized Emotion Detection using IoT and Machine Learning (Preprint)
Authors: Stanley Jothiraj Fiona Victoria
Published: November 2022

UNSTRUCTURED

The Medical Internet of Things, a recent technological advancement in
medicine, is incredibly helpful in providing real-time monitoring of health
metrics. This paper presents a non-invasive IoT system that tracks patients'
emotions, especially those with autism spectrum disorder. With a few affordable
sensors and cloud computing services, the individual's heart rates are
monitored and analyzed to study the effects of changes in sweat and heartbeats
per minute for different emotions. Under normal resting conditions of the
individual, the proposed system could detect the right emotion using machine
learning algorithms with a performance of up to 92% accuracy. The result of the
proposed approach is comparable with the state-of-the-art solutions in medical
IoT.
Technology-Assisted Cognitive Motor Dual-Task Rehabilitation in Chronic Age-Related Conditions: Systematic Review (Preprint)
Authors: Tuena Cosimo , Borghesi Francesca , Bruni Francesca , Cavedoni Silvia , Maestri Sara , Riva Giuseppe , Tettamanti Mauro , Liperoti Rosa , Rossi Lorena , Ferrarin Maurizio , Stramba-Badiale Marco
Published: November 2022

BACKGROUND

Cognitive-motor dual-task (CMDT) is defined as the parallel processing of motor (eg, gait) and cognitive (eg, executive functions) activities and is an essential ability in daily life. Older adults living with frailty, chronic conditions (eg, neurodegenerative diseases), or multimorbidity pay high costs during CMDT. This can have serious consequences on the health and safety of older adults with chronic age-related conditions. However, CMDT rehabilitation can provide useful and effective therapies for these patients, particularly if delivered through technological devices.

OBJECTIVE

This review aims to describe the current technological applications, CMDT rehabilitative procedures, target populations, condition assessment, and efficacy and effectiveness of technology-assisted CMDT rehabilitation in chronic age-related conditions.

METHODS

We performed this systematic review, following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, on 3 databases (Web of Science, Embase, and PubMed). Original articles that were published in English; involved older adults (>65 years) with ≥1 chronic condition and/or frailty; and tested, with a clinical trial, a technology-assisted CMDT rehabilitation against a control condition were included. Risk of bias (Cochrane tool) and the RITES (Rating of Included Trials on the Efficacy-Effectiveness Spectrum) tool were used to evaluate the included studies.

RESULTS

A total of 1097 papers were screened, and 8 (0.73%) studies met the predefined inclusion criteria for this review. The target conditions for technology-assisted CMDT rehabilitation included Parkinson disease and dementia. However, little information regarding multimorbidity, chronicity, or frailty status is available. The primary outcomes included falls, balance, gait parameters, dual-task performance, and executive functions and attention. CMDT technology mainly consists of a motion-tracking system combined with virtual reality. CMDT rehabilitation involves different types of tasks (eg, obstacle negotiation and CMDT exercises). Compared with control conditions, CMDT training was found to be pleasant, safe, and effective particularly for dual-task performances, falls, gait, and cognition, and the effects were maintained at midterm follow-up.

CONCLUSIONS

Despite further research being mandatory, technology-assisted CMDT rehabilitation is a promising method to enhance motor-cognitive functions in older adults with chronic conditions.

CLINICALTRIAL
Sterilisasi Peralatan dan Media Kultur Jaringan
Authors: Wulandari Sri , Nisa Yonita Sholihatun , Taryono Taryono , Indarti Siwi , Sayekti Rahmi Sri
Published: November 2022

Plant tissue culture is a technology used to propagate plants under controlled and aseptic environmental conditions. One of the obstacles in tissue culture activities is the presence of bacterial and fungal contamination. Equipment and growing media that are used for tissue culture can be the source of contamination. The method that can be used to reduce contamination is using sterilization. Sterilization is used to kill or eliminate microorganisms so that the equipment and media are free from contaminants. Equipment sterilization can be done through several methods such as wet sterilization and dry sterilization. Wet sterilization is carried out using an autoclave, while dry sterilization can be carried out using an oven, fire, and glass bead sterilizer. Media sterilization is generally carried out using an autoclave or membrane filter.
Significance of Fundamental Equations for Electrical Prospecting
Authors: Ramakrishna B. , Rao T. Vinoda , Kumar M. Pavan , Praveen K. Leela , Kumar N. Praveen , Sreedhar P.
Published: November 2022

Abstract: Determination of hydrological properties of the aquifer is of fundamental importance in hydro-geological and geoelectrical studies. An attempt has been made to review briefly the fundamental equations that form the basis of electrical prospecting and relationship with the aquifer parameters in terms of hydrogeologic and electrical soundings. The empirical relationship between hydrogeologic and Dar Zarrouk parameters will also need to review the concepts of anisotropy, equivalence, and suppression for characterization of the water quality through the electrical resistivity.
A Prediction of SNMDs with Machine Learning
Authors: M Ovya , V Prakathi , RS Lisa , S Nikitha , B Gomathi
Published: November 2022

Abstract: The complex use of social networking follows the enormous rise in popularity. Recently, an increasing number of social and intellectual problems have been identified, including information overload, cyber-relationship addiction, and net compulsion. Numerous studies have found that frequent usage of social media is closely linked to an increased risk of depressive symptoms, anxiety, loneliness, self-harm, and even suicide thoughts. These intellectual problems are now typically detected passively, leading to delayed scientific intervention. Throughout this project, we contend that analyzing online social behavior provides a way to actively find SNMDs early on. Future care and treatment options are made possible by an early diagnosis. Because the intellectual reputation cannot be immediately determined from online social interest logs, it is difficult to identify SNMDs. Therefore, we propose a system learning framework called Networking Site Mental Disorder Tracking (SNMDD), which utilizes features retrieved from familiar social knowledge to as it should be. We advise using SNMD-based Tensor Models to increase accuracy (STM). Boosting overall performance in order to increase scalability. Our methodology is examined personally by 3126 members of online social communities. We conduct a function analysis, follow SNMDD on sizable datasets, and look at the characteristics of the three SNMD kinds. The outcomes show that SNMDD is effective in identifying online social community users who possess SNMDs.
Comparative Study on Hybrid and Traditional Seed Cultivars of Finger millet (Eleusine coracana L.)
Authors: Yogeshwari M. A. , Kalpashree M. M. , Yashwanth D. , Krishna Dr. K.
Published: November 2022

Abstract: Four cultivars of finger millet were taken in study, two were hybrid cultivars (KMR-340 and MR-6) and other two were traditional cultivars (MR-1 and GPU-28). Tests have been conducted for this study such as germination test, estimation of chlorophyll, total protein, total phenols, enzymatic activity and phytochemical analysis. The results revealed that highest rate of germination percentage and vigour index in hybrid cultivar i.e., MR-6 it has 86% of germination on 14th day. Chlorophyll content also high in MR-6 (0.075 mg/g) on 14th day. Total protein content was more in hybrid cultivars KMR-340 (145 mg/g) on day 14th than traditional cultivars. Whereas enzymatic activity and total phenol content was highest in traditional cultivars.
Fra neutral implementering til hviskeleg - om oversættelse af strategien ”værdibaseret sundhed”
Authors: Madsen Søren Obed , Sundquist Mille
Published: November 2022

Reformer og strategier gives ofte som svaret på samfundsmæssige problemer, men tit udebliver de ønskede resultater. Der bruges mange ressourcer på at udvikle disse tiltag, men tilsyneladende medfører implementeringen, at tiltagene forandrer sig, når ordene i dokumenterne skal omsættes til handlinger. Der sker altså et eller andet i mødet mellem planen og virkeligheden. Denne artikel analyserer, hvorfor en strategi forandrer sig, når den bliver implementeret vertikalt igennem fem ledelseslag. Ved at anvende oversættelsesteori til at studere, hvordan implementeringen foregår i praksis, viser det sig, at hver chef læser strategien ud fra forskellige kilder og har forskellige forståelser for, hvilken organisation som de arbejder i. Det skaber fem forskellige oversættelser af den samme strategi, der udfordrer antagelsen om, at strategier implementeres neutralt igennem ledelseslagene. Artiklen peger på, at der er behov for at nytænke forholdet mellem strategi som plan og strategi som proces ved at bruge strategi som tekst som en brobygning mellem de to andre perspektiver.
Kommende artikler
Authors: Melander Preben
Published: November 2022

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Análisis de sobrevivencia de una herramienta mediante un modelo de redes bayesianas-CPH
Authors: Pinto Santos Jorge Adolfo , Rodríguez Medina Manuel Arnoldo , Poblano-Ojinaga Eduardo Rafael , Rodríguez Borbón Manuel Iván , Gómez Zepeda Perla Ivette
Published: November 2022

Uno de los grandes problemas de la industria es el mantenimiento, y específicamente el cambio de las herramientas típicas de desgaste. Actualmente, las empresas manejan el mantenimiento productivo total, que centra a los técnicos de mantenimiento principalmente en el mantenimiento correctivo y en menor grado, en el mantenimiento preventivo. Sin embargo, muy pocas empresas hacen análisis de manera formal del mantenimiento predictivo. El establecer una metodología para el mantenimiento predictivo requiere analizar los diferentes modelos de degradación de la herramienta mediante la relación de esta con la función de distribución de probabilidad que desarrolla. Este documento contempla el análisis de un electrodo para soldadura de contacto (ultrasónica) a través del comportamiento de su degradación, gracias a lo cual es posible obtener la función de densidad de probabilidad que se ajusta mejor al comportamiento del desgaste de la herramienta. Además, se determinan los factores que influyen en el no cumplimiento en la resistencia a la tensión de las piezas soldadas. Se utiliza el modelo de riesgo proporcional de Cox y las técnicas del diseño de experimentos, lo que se considera como la base para implementar el programa de mantenimiento predictivo.
Investigation on the performance of the expansion water seal by using isogeometric analysis with variational inequalities for the frictional contact
Authors: Zhou Y. , Hu K. , Hu T. , Shi S. , Han Y. , Wang J. , Lou Y. , Hou T.
Published: November 2022

In this study, IGA is introduced into the performance analysis of the expansion water seal for an exact representation of its complex geometrical shape. Firstly, the incremental equilibrium equations used in the large deformation analysis are derived for the IGA discretization model based on the updated Lagrangian formulation. The unknown contact forces are directly involved in the equilibrium equations, which results in a simple expression. Then, through the investigation of the contact conditions, the normal and tangential contact forces are verified to be the solutions of two box-constrained variational inequalities representing the normal and tangential contact conditions, respectively. Furthermore, the incremental equilibrium equations for all components of the water seal system and the variational inequalities for all contacts between the components are assembled together and reformulated as a global variational inequality, which is resolved by using the Extra-gradient method. Ultimately, the new method is applied in the performance comparison of two optional expansion water seals, in which the capability and precision of the proposed method are investigated. Results verify that the proposed method is effective in the numerical simulation of the expansion water seal and has a higher precision than the traditional FEM under the same conditions.
Factors Affecting Student Satisfaction in Distance Learning: A Case Study of COMSATS (VIRTUAL CAMPUS)
Authors: Rizwan Muhammad
Published: November 2022

Generally, In Pakistan people perceived that quality of distance learning education is poor. Therefore, we decided to carry out the study to see if it’s only people opinion or legend. The aim of the study is to analyze the association between instructor performance (IP), student instructor interaction (SII), course evaluation (CE) and student satisfaction (SS) variables in distance education by taking Virtual COMSATS as a Case study. Target population of this research was the COMSATS (VIRTUAL CAMPUS). students out of which 251 graduate and undergraduate students were selected as sample for current research. The purpose of this research study was to understand the key factors affecting student satisfaction in distance learning .Researchers also collect information through primary data using survey questionnaire that distributed through email to all the students of VCOMSAT. From literature review it was found that in distance learning education student satisfaction is based on instructor performance, student-instructor interaction, course evaluation, Learning management system use, instructor attitude etc. From literature review we found that course evaluation and instructor performance is very important for student satisfaction in distance learning. Researchers need to compare student’s satisfactions with subject wise. Comparison of practical subjects and without practical subjects needs to identify with student satisfaction. There is also required to compare lecturer motivation with student satisfaction and performance. Future research is also need to compare satisfaction of rural area and urban areas students in distance learning education and also need to compare with traditional education.
Socio-Medical Characteristics Of Patients With Lumbar Discopathy
Authors: Alexandra-Liliana Cioara , Irina Albadi , Andreea-Alexandra Lupu
Published: November 2022

Lumbar discopathy remains an actual problem with a high frequency among people within 35-45 years. In most of the cases, the hernia is located in the lumbar area, most frequently at L4 or L5. In this region, the dorsal vertebral ligament is narrower and less developed, the spine has a higher lordosis and special mobility, all these things leading to an easier transmission of the traumatic shocks. Most often anatomical factors are combined with the environmental ones, favoring degenerative modifications in the spine. The purpose of this analysis is to see the socio-medical impact on the most common pathology of the spine.
Presentation of so far undetermined bird remains from the Upper Miocene (MN13) of Polgárdi 4 and 5 (Fejér county, West Hungary)
Authors: Kessler Jenő Eugen , Horváth Ida
Published: November 2022

The authors have identified the mostly very fragmentary bird fossils from the uncatalogued material of the Hungarian Institute of Geology and Geophysics to the level that the condition of the bones allows. Almost half of the 102 bone pieces (42 fragments) could be completely or partially identified, while the rest (60 fragments represented either by bone fragments or by toe phalanges, claws, mandibles, etc.) could not be identified. The material identified includes taxa previously published and known from the site, but a good number of these are represented by other bones or parts of bones, as in previous publications (Palaeortyx phasianoides Milne-Edwards, 1869, Palaeocryptonix hungaricus Jánossy, 1991, Porzana † kretzoii Kessler, 2009, Glaucidium † baranensis Kessler, 2010, Apus † baranensis Jánossy, 1977, Lullula † minor Kessler, 2013, Delichon † polgardiensis Kessler, 2013, Riparia † major Kessler, 2013, Sitta † gracilis Kessler, 2013). The taxa identified at order, family or genus level are listed in the main text and complemented by one figure, as well as a rich bibliographic material.
SOCIO-ECONOMIC IMPLICATIONS OF RURAL POPULATION MIGRATION
Authors: BURLACU Sorin , STOICA Gabriela Dalila , GIUCĂ Daniela Andreea , STERIE Maria Cristina
Published: November 2022

Considering the debates regarding population migration from rural areas, the purpose of this study is to analyze socio-economic indicators to identify the main challenges of rural areas in Romania as well as to identify solutions to ensure the development of the Romanian rural environment. Our research aims to present the socioeconomic consequences of the rural population's migration by analyzing indicators such as the population by domicile by residence, the average age of the population by domicile, the flow of internal urban and rural migration, the population activity rate, the employed population per economic activities, and the total average monthly income obtained by a rural person. In addition, at the end of the study, a Pearson correlation was made with the help of the SPSS software, which identified the link between income from agriculture and the number of people working in agriculture. The results obtained indicated that while the number of people employed in agriculture, forestry, and fishing is decreasing, the average total income from agriculture is increasing. On the other hand, the migration of the population from the rural area to the urban area is on average about 82 thousand people and the rural population is in a continuous decrease, while the average age registered in the rural area is higher compared to the average age registered in urban areas.
The effect of Vitamins C and E on clinical outcomes of patients with severe traumatic brain injury: A propensity score matching study
Authors: Khalili Hosseinali , Abdollahifard Saeed , Niakan Amin , Aryaie Mohammad
Published: November 2022

Background:

The aim of this study was to assess the effect of Vitamins C and E on mortality, intensive care unit (ICU) length of stay, and Glasgow Outcome Scale-Extended (GOS-E) score of traumatic brain injury (TBI) patients.

Methods:

Using data from records of patients in a retrospective cohort study, we included 1321 TBI patients, 269 treated and 1052 untreated, aged over 18 years with information on exposure (i.e., Vitamins C and E) and confounders. Age, Glasgow Coma Scale, pupil status, Rotterdam classification, blood sugar, blood pressure, international normalized ratio, and comorbidity of patients were considered as the confounding factors. Endpoints were GOS-E on follow-up, mortality, and ICU length of stay. Propensity score matching was performed to adjust the confounders.

Results:

Based on the average treatment effect estimates, the use of Vitamins C and E reduced the risk of mortality (risk difference [RD]: −0.07; 95% confidence interval [CI]: −0.14–−0.003) and reduced the length of ICU stay (RD -1.77 95% CI:-3.71-0.16). Furthermore, our results showed that GOS-E was improved significantly (RD: 0.09, 95% CI : 0.03-0.16).

Conclusion:

Our study suggests that using Vitamins C and E could decrease mortality and length of ICU stay and improve the GOS-E score and functions of the patients with severe TBI. As they are safe and inexpensive medications, they can be used in routine practice in ICUs to improve the outcomes of TBI patients.
Isolation of Bis(2-Ethylhexyl) Terephthalate and Bis(2-Ethylhexyl) Phthalate from Capparis spinosa L. Leaves
Authors: Kdimy Ayoub , Kim Seong Jong , Ali Zulfiqar , Khan Md Imdadul , Tripathi Siddharth , El Hajjaji Souad , Le Hoang
Published: November 2022

Capparis spinosa L., commonly known as the caper bush, is a spiny shrub known for its edible flower buds and its use as a medicinal plant in traditional medicine. While performing bio-guided isolation of active compounds from Capparis spinosa L. leaves and buds, large amounts of bis(2-ethylhexyl) terephthalate (DEHT, a.k.a. dioctyl terephthalate or DOTP) and bis(2-ethylhexyl) phthalate (DEHP) were isolated from a fraction from the leaf extract that showed antifungal activity against Cryptococcus neoformans. The structures of these two compounds were confirmed by NMR and mass spectroscopic data, which matched with those from the standards that were purchased from Sigma-Aldrich. DEHT and DEHP are phthalic and terephthalic acid esters, the main plasticizers that are used to confer elasticity and flexibility to various fiber and plastic products. This is the first time DEHT and DEHP have been isolated from the leaves of a plant that is as commonly used as Capparis spinosa L. This study adds to the increase in the detection of plasticizers in our food and medicine sources and to the alarming concern about the potential effects of these compounds on human health.
Cardiopulmonary Resuscitation – An Updated Review with Guidelines
Authors: R Vaidyanathan
Published: November 2022

Cardiopulmonary resuscitation CPR is a primordial skill necessary for all medical nursing and allied health care professionals alike. As medical science is constantly and rapidly evolving continuous updation of the knowledge and skills of people working in this field is the need of the hour. This review is an effort to outline the physiological basis of resuscitation and present the updated guidelines with a focus on both in-hospital and out-of-hospital cardiac arrests and the challenges faced by the medical rescuers in our country.nbsp
Animal Bite Management Facilities in aRural Area Near Bangalore
Authors: Masthi N R Ramesh , Undi Malatesh
Published: November 2022

Background Rabies is almost always fatal but being a 100 preventable disease treatment for the prevention of rabies in humans exposed to rabies should begin promptly after the exposure. The vast majority of rabies deaths 84 occur in rural areas. There are various reasons contributing to it and non-availability of health care facilities for animal bite management in these areas is one among them.Methodology The study was conducted in the villages near Bangalore over a period of six months. All the health care facilities in the study area were visited and data was collected regarding the availability and storage of rabies biological by personal interview of the health personnel in charge of these health centres using a check list and also by observation of the storage of rabies biologicals in these health care facilities.Results Both government and private health care facilities in the study area lacked adequate resources for animal bite management.Conclusion The study showed that the health care facilities lacked training and resources for animal bite management in the rural area near Bangalore.
Distribution of Mosquito Larval Breeding Sites in the Urban Slums ofBengaluru, Karnataka: An Observational Study
Authors: M S Hema , Sanadi Shweta , D Souza Neha , S Geethu , Saral C S Rinisha , P M Nasreen , Pawar Pratap , Thangaraj Selvi , T S Ranganath
Published: November 2022

Background Periodic entomological surveillance must be done to identify changes in the distribution and density of vectors evaluate control programmes and to facilitate timely decisions regarding interventionsObjectives To identify the distribution of mosquito larval breeding sites in the urban slums of Bengaluru and to calculate entomological indices.Methods of collection of Data An observational study was conducted in August 2021 in the urban slums of Bengaluru in the field practice area of a government medical college. A team consisting of ASHA workers and health inspectors did a house-to-house survey to look for indoor and outdoor breeding sites of mosquito larvae. All possible water holding containers in and around the houses were carefully inspected with the help of torch light for the existence of mosquito larvae. Entomological indices like House Index HI Container Index CI and Breteau Index BI were calculated based on the number of houses and containers positive for Aedes larvae. Data was entered into MS Excel and analyzed using SPSS Version 20.0.Results A total of 2592 houses were surveyed. HI CI and BI were calculated to be 0.73 15.01 and 4.75 respectively. Most common breeding sites identified were cement tankscisterns both indoor and outdoor.Conclusion It is important to conduct periodic entomological surveys to predict and plan for possible epidemics of mosquito borne diseases.
Connection between the inverse Schur transformation for generalized Nevanlinna functions with the rational matrix functions of special type
Authors: Andreischeva Elena
Published: November 2022

In this paper we consider classical Schur transformation and inverse Schur transformation for generalized Nevanlinna functions.
Analisis Pemberian Hadiah dalam Produk Tabungan Berjangka Wadiah Berhadiah (SAJADAH) di BMT NU Situbondo
Authors: Rohmah Alifatur , Fauzi Rahman Ali
Published: November 2022

Baitul Mal wat Tamwil (BMT) adalah salah satu bentuk Lembaga Keuangan Mikro (LKM) berbasis syariah. Nama BMT memiliki dua istilah yaitu istilah baitul maal yang berarti pengelolaan harta ibadah dan istilah baitul tamwil yang berarti penghimpunan dan penyaluran dana komersial. Dalam BMT ada beberapa produk pembiayaan sebagaimana lembaga keuangan lainnya begitupula dengan BMT NU Situbondo yang memiliki beberapa produk pembiayaan. Namun ada satu produk yang menarik untuk dikaji di BMT NU Situbondo yakni produk simpanan berjangka wadiah berhadiah (SAJADAH) dimana nasabah akan mendapat hadiah langsung pada saat membuka tabungan tersebut. Hal tersebut menjadi menarik untuk dijadikan sebagai bahan penelitian karena dalam akad wadiah tidak boleh menjanjikan hadiah di awal akad. Dalam penelitian ini yang digunakan yaitu penelitian normatif sedangkan pendekatan yang digunakan adalah pendekatan analitis dimana produk tabungan SAJADAH menjadi objek penelitian. Hasil yang didapat dari analisis pemberian hadiah pada akad wadiah yang terjadi di BMT NU Situbondo yaitu praktik ini dibolehkan karena praktik pemberian hadiah di BMT NU Situbondo sesuai dengan ketentuan fatwa DSN-MUI dan tujuan pemberian hadiah tersebut tidak menyalahi ketentuan syariat.
DESAFIOS ENCONTRADOS PELO ENSINO UNIVERSITÁRIO NA ÁREA DA SAÚDE DURANTE A PANDEMIA DO COVID-19
Authors: Sobral de souza Celestina elba , Oliveira do Nascimento Julia
Published: November 2022

Este artigo tem como objetivo identificar os principais desafios enfrentados pelo ensino universitário na área da saúde durante a pandemia ocasionada pela COVID-19. Foi desenvolvida uma revisão integrativa da literatura de estudos publicados entre 2020 e 2021 nas bases de dados LILACS e Google Acadêmico. Por meio dessa análise, foi possível identificar que os fatores socioeconômicos, bem como os métodos utilizados no processo de ensino-aprendizado vêm representando grandes desafios ao ensino superior em saúde, uma vez que exercem grande impacto no acesso dos discentes às ferramentas necessárias e a qualidade do ensino. Portanto, é necessário que seja feita uma melhor avaliação métodos adotados no ensino na área da saúde, com o intuito de que os alunos possam ter a vivência plena das competências pedagógicas inerentes à formação em saúde.
ENSINO REMOTO NA EDUCAÇÃO BÁSICA NA COMUNIDADE INDÍGENA FEIJOAL – AMAZONAS
Authors: Carneiro Félix Franckson , Zoia Alceu
Published: November 2022

Este trabalho tem como objetivo averiguar como foi o atendimento aos alunos da comunidade Indígena Feijoal do município de Benjamin Constant – Amazonas, durante o período em que a escola foi obrigada a paralisar as suas atividades de ensino normal e adotou o ensino remoto, devido a pandemia da Covid-19. A modalidade escolhida pela secretaria de educação foi o atendimento através do Projeto Aula Via Rádio, desenvolvido a partir do ano de 2020, sendo que os alunos ouviam as aulas via rádio e acompanhavam com apostilas preparadas pela Secretaria de Educação. Buscamos através desta pesquisa compreender como foi a reação dos professores e das famílias diante de uma metodologia nunca antes praticada em uma escola indígena. Entre as principais dificuldades elencadas para a efetivação destas aulas está diretamente ligada as condições estruturais de acesso destas comunidades às tecnologias.
Using TED Talks Content for Foreign Language Auditive Competence Development among Technical University Students
Authors: Zakharova Olga Olegovna
Published: November 2022

The aim of the study is to substantiate the effectiveness of using the media content of the TED Talks platform for foreign language auditive competence development among technical university students within the “Foreign Language in Professional Activities” discipline. The paper clarifies the definition of the notion of technical university students’ foreign language auditive competence, its component composition, describes the possibilities of using TED Talks videos for its development. Scientific novelty lies in elaborating a model for foreign language auditive competence development among future engineers based on TED Talks videos. As a result, the positive results of a methodological experiment on the implementation of the considered model have been presented and the conditions for its functioning have been indicated.
Culturas midiáticas das juventudes
Authors: Pereira Cláudia
Published: November 2022

O objetivo é propor a categoria “culturas midiáticas das juventudes” como objeto de pesquisa voltado para práticas comunicacionais cotidianas dos jovens em sua pluralidade. Distingue-se de perspectivas que tomam tais práticas e representações como meras partes de outros objetos de pesquisa. A teoria se sustenta na discussão de Rossana Reguillo sobre o papel dos jovens como atores sociais. Como cultura em si mesma e, portanto, repleta de rituais e significados, as “culturas midiáticas das juventudes” são tomadas como o próprio objeto central da pesquisa. Apresenta-se um breve estudo de caso sobre dimensões de produção e consumo de narrativas publicitárias no contexto do skate de rua.
Mathematical methods for optimizing manipulator movement modes in an automated technological process
Authors: Ivanova Lubov , Ivanov Sergei
Published: November 2022

The paper considers an urgent scientific problem of optimizing the modes of movement of manipulators in an automated technological process. A method for optimizing the trajectory of movement of manipulators in an automated technological process is presented. The developed trajectory optimization method is used to increase the speed and optimize the movement of various manipulators
Do Mindsets Shape Intentions to Help Those in Need? Unraveling the Paradoxical Effects of Mindsets of Poverty on Helping Intentions
Authors: Graczyk Thomas , Wingen Tobias , Wingen Sophia , Dohle Simone
Published: November 2022

Poverty remains a pressing problem affecting both individuals and societies, with social support playing a crucial role in poverty reduction. The intention to help those in need might be strongly influenced by mindsets of poverty, i.e., peoples’ beliefs about the changeability of poverty. Drawing on previous research on health-related mindsets, we propose that a growth mindset of poverty—that is, believing poverty can be changed—can have both positive and negative effects on helping intentions through increased outcome expectancy and blame, respectively. In a series of three experiments, we examine this relationship in more detail. Study 1 found that a growth mindset of poverty is associated with increased outcome expectancy and blame, which, in parallel, mediate the relationship between mindsets and helping intentions. However, these contrary indirect effects cancel each other out, resulting in a total null effect. We observed an identical pattern in Studies 2 and 3. Further, manipulating the relationship between mindset and outcome expectancy (but not blame) alters the relationship between mindsets and helping intentions (Studies 2 and 3). By shedding light on the circumstances under which mindsets of poverty can diminish or amplify helping intentions, our research offers valuable insights for practitioners and charities dedicated to combating poverty.
Equation for Emergence of Electric Charge from Spin
Authors: Apell Agona
Published: November 2022

I propose that electric charge is an emergent property of a spinning body. Specifically, an elementary particle or celestial body whose surface rotates about its axis or centre develops a charge Q = kmω√(ε_0/ρ), where k is a dimensionless constant, m is the mass of the sphere, ω is the angular velocity of its surface, ρ its density, and ε_0 the permittivity of free space. I argue that the charge so developed is an important contributory factor to planetary magnetism and propose a calculation for the component of a planet’s magnetic field strength that arises from its orbital motion. I also reframe Coulomb’s law to express the electrostatic force between two charged particles in terms of their masses, densities, and angular velocities. I further show that our proposed equation of charge development leads to the well-known relationship e = √(2αhcε_0) if we assume that the electron is a spherical particle and that every point on its surface revolves about its centre at velocity c – effectively suggesting that the electron has a fluid-like surface and is not a point particle. This said assumption also enables us to not only visualize electron spin for the very first time but also to calculate both the intrinsic magnetic dipole moment of the electron and its spin angular momentum without invoking laborious mathematical methods or attributing infinite energy to the electron, thus according with the principle of parsimony. The paper ends with a conclusion and recommendation for further study.
The neural development of auditory temporal modulation processing for phonetic perception in the first year of life
Authors: Hegde Monica Susheela , Cabrera Laurianne
Published: November 2022

Infants start to show signs of speech-perceptual attunement, that is, specialization for consonants in their native language, during their first year of life. The current study investigated the role that speech-auditory mechanisms play in this early speech perceptual phenomenon. Using a psychoacoustic approach combined with electrophysiology, this study explored the neural underpinnings of key acoustic components of speech: amplitude and frequency modulations (AM/FM). Cortical auditory evoked potentials (CAEPs) were measured for native (voiced /b/ and unvoiced unaspirated /p/) and non-native (unvoiced aspirated English /ph/) consonants in French-learning 6-month-old, 10-month-old and French adult listeners. Three acoustically manipulated conditions were designed to selectively preserve : 1) original FM and AM, 2) original AM only, and 3) the slowest AM (< 8 Hz) only. Results showed that 6-month- and 10-month-old CAEPs are differently affected by temporal degradation for consonant processing, suggesting that neural speech-auditory mechanisms for processing FM and AM cues develop during the first year of life.