bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenging the Current Paradigm of Liquid Biopsy Through Dielectrophoresis (DEP) In Prostate Cancer
Authors: Russo Giorgio I. , Musso Nicolò , Romano Alessandra , Caruso Giuseppe , Petralia Salvatore , Lanzanò Luca , Broggi Giuseppe , Camarda Massimo
Published: December 2021

Liquid biopsy via isolation of circulating tumour cells (CTCs) represents a promising diagnostic tool capable of supplementing state-of-the-art for prostate cancer (PC) prognosis. Unfortunately, most of CTC technologies, such as AdnaTest or Cellsearch, critically rely on the Epithelial-Cell-Adhesion-Molecule (EpCAM) marker, limiting the possibility of detecting stem-like cells (CSCs) and mesenchymal-like cells (EMT-CTCs) that are present during PC progression. In this tontext, dielectrophoresis (DEP) is an epCAM independent, label-free, enrichment system, separating rare cells simply on the basis of their specific electrical properties. As compared to other technollgies, DEP represents a superior technique in terms of running costs, cells yield and specificity, but due to its higher complexity, requires still further technical as well as clinical development. Interestingly, DEP can be improved by the use of microfluid, nanostructured materials and fluoroimaging in order to increase its potential applications. In the context of PC, the utility of DEP can be translated in its capacity to detect CTC in the bloodstream in their epithelial, mesenchymal, or epithelial-mesenchymal phenotypes, which should be taken into account when choosing CTC enrichment and analysis methods for PC prognosis and early diagnosis.
Linear Lengthening in Iwaidja: An Event-Quantifying Intonation at the Phonology to Semantics/Pragmatics Interface
Authors: Caudal Patrick , Mailhammer Robert
Published: December 2021

This paper investigates the meaning of a specific intonation contour found in the Northern Australian language Iwaidja called Linear Lengthening Intonation (LLI). Using an experimental field work approach, we analysed approximately 4,000 utterances. We demonstrate that the semantics of LLI is broadly event-quantificational as well as temporally scalar. LLI imposes aspectual selectional restrictions on the verbs it combines with (they must be durative, i.e. cannot describe ‘punctual’, atomic events), and requires the event description effected by said verbs to exceed a contextually-determined relative scalar meaning (e.g., a ‘typical duration’ à la (Tatevosov 2008)). Iwaidja differs from other Northern Australian languages with similar intonation patterns (see e.g. (Bishop 2002: 2002; Simard 2013)), in that it does not seem to have any argument NP-related incremental or event scalar meaning. This suggests that LLI is a decidedly grammatical, language-specific device; not a purely iconic kind of expression (even though it also possibly has an iconic dimension).
Big Data Handling Approach for Unauthorized Access of Cloud Computing
Authors: Razaque Abdul , Nazerke Shaldanbayeva , Alotaibi Bandar , Alotaibi Munif , Murat Akhmetov , Alotaibi Aziz
Published: December 2021

Nowadays, cloud computing is one of the important and rapidly growing paradigms that extend its capabilities and applications in various areas of life. The cloud computing system challenges many security issues, such as scalability, integrity, confidentiality, and unauthorized access, etc. An illegitimate intruder may gain access to the sensitive cloud computing system and use the data for inappropriate purposes that may lead to losses in business or system damage. This paper proposes a hybrid unauthorized data handling (HUDH) scheme for Big data in cloud computing. The HUDU aims to restrict illegitimate users from accessing the cloud and data security provision. The proposed HUDH consists of three steps: data encryption, data access, and intrusion detection. HUDH involves three algorithms; Advanced Encryption Standards (AES) for encryption, Attribute-Based Access Control (ABAC) for data access control, and Hybrid Intrusion Detection (HID) for unauthorized access detection. The proposed scheme is implemented using Python and Java language. Testing results demonstrate that the HUDH can delegate computation overhead to powerful cloud servers. User confidentiality, access privilege, and user secret key accountability can be attained with more than 97% high accuracy.
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Authors: parker jim , O'Brien Claire , Hawrelak Jason , Gersh Felice
Published: December 2021

Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic disorder that manifests in genetically susceptible women following a range of negative exposures to nutritional and environmental factors related to contemporary lifestyle. The hypothesis that PCOS phenotypes are derived from a mismatch between ancient genetic survival mechanisms and modern lifestyle practices is supported by a diversity of research findings. The proposed evolutionary model of the pathogenesis of PCOS incorporates evidence related to evolutionary theory, genetic studies, in-utero developmental epigenetic programming, transgenerational inheritance, metabolic features including insulin resistance, obesity and the apparent paradox of lean phenotypes, reproductive effects and subfertility, the impact of the microbiome and dysbiosis, endocrine disrupting chemical exposure, and the influence of lifestyle factors such as poor quality diet and physical inactivity. Based on these premises, the diverse lines of research are synthesized into a composite evolutionary model of the pathogenesis of PCOS. It is hoped that this model will assist clinicians and patients to understand the importance of lifestyle interventions in the prevention and management of PCOS and provide a conceptual framework for future research. It is appreciated that this theory represents a synthesis of the current evidence and that it is expected to evolve and change over time.
A Review on Solution-Processed Organic Phototransistors and Their Recent Developments
Authors: Tavasli Aybuke , Gurunlu Betul , Gunturkun Dilara , Isci Recep , Faraji Sheida
Published: December 2021

Today, more disciplines are intercepting each other, giving rise to “cross-disciplinary” research. Technological advancements in material science and device structure and production have paved the way towards development of new classes of multi-purpose sensory devices. Organic phototransistors (OPTs) are photo-activated sensors based on organic field-effect transistors that convert incident light signals into electrical signals. The organic semiconductor (OSC) layer and three-electrode structure of an OPT offer great advantages for light detection compared to conventional photodetectors and photodiodes, due to their signal amplification and noise reduction characteristics. Solution processing of the active layer enables mass production of OPT devices at significantly reduced cost. The chemical structure of OSCs can be modified accordingly to fulfil detection at various wavelengths for different purposes. Organic phototransistors have attracted substantial interest in a variety of fields, namely biomedical, medical diagnostics, healthcare, energy, security, and environmental monitoring. Lightweight and mechanically flexible and wearable OPTs are suitable alternatives not only at clinical levels but also for point-of-care and home-assisted usage. In this review, we aim to explain different types, working mechanism and figures of merit of organic phototransistors and highlight the recent advances from the literature on development and implementation of OPTs for a broad range of research and real-life applications.
The Selection of the Best Deal for Sweet Potato Contract Farming under Directing of Multinomial Logit Model: An Application of the Theory of Planned Behavior
Authors: Chang Ke-Fen , Wu Pei-Ing , Liou Je-Liang , Yang Shou-Lin
Published: December 2021

The purposes of this study are based upon the theory of planned behavior (TPB) to examine the impact of past experiences of contract farming on selecting a specific type of contract farming in the future and then compare different psychological factors in the TPB for different potential contract farmer statuses. These statuses include homesteaders, farmers from cooperative farms, farmers from production and sales teams, professional farmers, and brokers. The impact of factors in the TPB for a particular contract type on potential contract farmers is further to compute. To this end, data are collected in three major sweet potato production areas in Taiwan. The results show that the farmers’ past contract farming experience does not influence the selection of the contract in the future. As for the selection of contract type, strengthening the perception and motivating the behavioral intention of contract farming for cooperative farms will increase the probability of selecting an unclassified sweet potato size contract. On the other hand, enhancing perceived behavioral control factors and behavioral intention factors for professional farmers and brokers is apt to have a relatively high probability of selecting those types involving the highest amount or the best price to obtain the best deal.
AN ASSESSMENT OF THE INTENTION TO ACCEPT SHARIAH COMPLIANT CROWDFUNDING MODE OF FINANCING IN BORNO STATE, NIGERIA
Authors: Sulaiman Sagir Muhammad , Muhammad Yusuf , Muhammad Muhammad Abdulaziz
Published: December 2021

Micro-, small and medium-sized enterprises (MSMEs) face numerous obstacles, such as a lack of funding, which hinder their growth and expansion. They must have access to long-term funding to improve and modernise their operations competitively. This study aims to incorporate Shariah-compliant crowd funding among MSMEs in Borno state of Nigeria. It applies partial least squares  structural equation modelling (PLS-SEM) on a sample of 341 MSMEs and recommends the need to educate and enlighten them about the benefits of Islamic crowdfunding. The study also recommends the need to produce guidelines that will help in developing a legal and regulatory framework for the incorporation of crowdfunding into corporate financing structures. Finally, it is recommended that religious leaders at various levels organise educational programmes on the importance of Shariah-compliant crowdfunding.
UNDERSTANDING THE IMPACT OF INSTITUTIONAL FACTORS ON ASNAF’S SUSTAINABILITY: A PLS-SEM APPROACH
Authors: Al Haq M Ashraf , Abd Wahab Norazlina , Alam Md. Mahmudul
Published: December 2021

This study examines the impact of zakat on the life sustainability of individuals. The data were collected from 427 returned questionnaires from zakat recipients in eleven districts of Kedah. Using PLS-SEM, it was found that asnafs’ receiving offers a very low level of assistance that provides little empowerment. The results support the notion that institutional contributory performance has a positive effect and that the level of sustainability does increase after receiving zakat, but there are issues that need to be addressed carefully. The study further examines the moderating role of demographic factors, such as earnings, age, marital status and gender. It initiated a newer dimension through incorporating before-zakat and after-zakat scenarios in examining their comparative impact on sustainability.
REVITALIZING INDONESIAN ISLAMIC BANKING PERFORMANCE: A STAKEHOLDER ANALYSIS
Authors: Pertiwi Ruspita Rani , Tjakratmadja Jann Hidajat , Febriansyah Hary
Published: December 2021

This paper examines views of Islamic banks’ stakeholders, which can be used as bases for measuring and improving bank performance.  Taking Indonesia as a case study, we compile information and data from  both internal and external stakeholders through in-depth interview and FGD, code them  using N-Vivo, and finally apply the stakeholder management framework for data analysis. The results we obtain suggest that the Internal stakeholder's view on IIB performance is relatively positive.  Meanwhile, the external stakeholders tend to have varied views on Islamic banking  performance. This research finds that the religious values ​​promoted by Islamic banks can increase the company's value but at the same time it can also reduce the interest in Islamic banking.  Based on these findings, it is necessary to investigate further how to strategize the religious values for the promotion of Islamic banking.
Methods of Current Limitation in Low Voltage (up to 1 kV) Electric Networks
Authors: Kapustsinski A. Yu. , Kanstantsinava S. V.
Published: December 2021

The article discusses and systematizes the causes of high values of short-circuit currents in electrical networks up to 1 kV and indicates their negative consequences. A brief analysis of some current limiting methods (both with and without additional investment) is given, which makes it possible to reduce the negative effects when significant short-circuit currents occur. The variants of the implementation of these current limiting methods recommended for study at the design stage or when replacing equipment that has exhausted its resource, are considered. The advantages and disadvantages of the methods of limiting short-circuit currents described in the article are indicated. Options for connecting equipment with low power consumption to nodes of the electrical network up to 1 kV with high values of short-circuit currents are also considered. Special attention is paid to current-limiting protection devices, a detailed description of the design of some of them is given, the advantages of their use in comparison with other current-limiting methods are indicated, the corresponding graphs of the limitation of the periodic component of the short-circuit current, shock short-circuit current and thermal pulse are presented. Based on the analysis of graphic materials, the issue of ensuring the selectivity of protections is considered. The degree of prevalence of equipment with the property of current limitation is determined. A method for determining selective current-limiting protection devices is given, viz. the method of energy selectivity, the corresponding graphs for determining energy selectivity are presented. The physics allowing to determine the degree of efficiency of limiting the short-circuit current is described. Recommendations on the use of current-limiting equipment are proposed.
Study of Parametric Interactions in the Nuclear Reactor Control with Feedback
Authors: Opiatiuk V. V. , Kozlov I. L. , Skalozubov V. I. , Ostapenko I. A.
Published: December 2021

This article considers the principal theoretical possibility of regulating a nuclear power reactor under changing operating modes conditions when external periodic disturbances take place in conditions of changing the operating mode. By the external periodic perturbation a downward change in the conditions of the heat sink was meant. The magnitude of the changes was preliminarily calculated in such a way that the operating conditions of the power plant did not exceed the boundaries of the safe operation zone of the reactor. In the case of approaching the operation parameters to the critical ones, the heat sink was increased until the working conditions returned to their previous state. In this work the amplitude frequency response of a non-linearly enhanced system in the nuclear power plant operating conditions when non-linearly reacting to external periodic influences has been studied. The external cyclic disturbances effect produced on the reactor that initially existed under stationary operating conditions has been considered. The research was carried out by numerical simulation of the competition between processes occurring in a nuclear power plant and determined by the system’s reaction time and relaxation time while responding to periodic external influences. Calculations of the relaxation time dependence on the fixed frequency-revealing external influence’s temperature are presented. Also, the relaxation time dependence on the frequency of external influence at a fixed temperature for systems with various relaxation periods was calculated. It is determined that when the dependence between system temperature and the external influence time is calculated, there exists a wide range of possible frequency control. To evaluate the behavior of a nuclear power reactor under conditions of operating modes changes, a fundamental physical mathematical model of the reactor’s state under external harmonic influence is presented. It is based on the nonlinear Riccati equation. The external harmonic effect was simulated by changing the heat supply and heat removal conditions near the critical point.
Methodological Basis of Virtual Reality Technology Application in Industrial Design
Authors: Konstantinova A. A. , Ivchenko V. I. , Bakhonka V. V. , Salauyeu M. V. , Mаisei V. N.
Published: December 2021

The paper is devoted to the development of methodological foundations for the application of virtual reality technologies (VR-technologies) at various stages of car design and their promotion on the market, in particular, when performing design, prototyping, development of educational and advertising products. The paper analyzes the main areas of application of virtual reality technologies in industrial design in mechanical engineering. An overview of the parameters of the specialized software Unreal Engine 4 and the HTC Vive hardware set used to create and demonstrate virtual projects is performed. System requirements for computer software and hardware for creating virtual projects have been formed. A generalization of our own experience of using virtual reality technologies in the design of an electric vehicle with a frame-panel structure is carried out. The technique of using virtual reality tools in order to create virtual projects for demonstration of design solutions and functionality of mechanical engineering products is described. The issues of choosing software and hardware, their characteristics are considered, as well as a description of the stages of creating a virtual project is given. The process of developing a virtual project is divided into the stages of preparing and transforming a three-dimensional computer model of the demonstrated product into its virtual digital prototype, creating a virtual environment for it, assigning materials and textures with the necessary properties to the environment and the object, setting lighting, navigation parameters and animated actions, optimizing the display of shadows and finalizing the project. The main results of approbation of the developed methodology are presented on the example of creating virtual projects for demonstrating an electric vehicle: in an urban virtual environment and in a virtual pavilion.
Estimation Impact of Capital Development Projects on Adjacent Street and Road Network in Organization of Traffic by Means of Signal Controlled Intersections
Authors: Zedgenizov A. V. , Kapskiy D. V. , Lagerev R. Yu.
Published: December 2021

The paper discusses problems of assessing the impact of mass attraction centers on the adjacent street and road network in the process of their functioning, expansion or conversion. The choice of criteria for assessing the organization of traffic flow, given in the Russian and foreign literature, has been substantiated, in particular, it is proposed to use v/c ratio for adjacent junction and corresponding level of traffic service (LOS). The main models for estimating capacity of signalized intersections are presented. The procedures of forming a mathematical model for estimating the load factor of signalized intersections is shown. The concepts of lane group capacity, total lost time per cycle, phase coefficients, saturation flow rate, and coefficients taking into account the decrease in the ideal saturation flow rate are explained. A mathematical model for estimating transport demand is presented, which allows to calculate the intensity of traffic flow to and from the center of mass attraction on the basis of the total traffic flow of correspondence, share of visitors in individual transport, average filling of individual transport, and coefficient of daily irregularity upon arrival and departure of visitors on an individual transport. An integrated mathematical model of loaf factor is proposed which includes parameters for estimating transport demand for centers of mass embarrassment and parameters that determine the signalized intersections capacity. The uniqueness of the integrated model is that it simultaneously involves parameters reflecting the demand and capacity of loading intersection. Recommendations are made on assessing the level of traffic service flows and the v/s ratio, based on the data of transport demand and capacity, adjacent to the centers of mass attraction of the road network. The presented method of estimating the LOS based on the capacity of the signalized intersections allows us to estimate the influence degree of mass attraction centers on the adjacent urban road network.
Keharmonisan Keluarga Tenaga Kerja Wanita Perspektif Psikologi Keluarga Islam
Authors: Rohmawati Umi , Rusdiana Ika
Published: December 2021

Nowadays, due to the complex family economic problems, it is the reason for a wife to become a TKW abroad to improve the family's economy. This study aimed to determine the psychological analysis of Islamic families on the communication patterns of TKW families and to find out the psychological analysis of Islamic families on conflict resolution in TKW families from Gajah Village Ponorogo. The method used a qualitative method with data collection techniques with interviews and documentation. The results showed that the communication pattern of the TKW families in Gajah Village was by the Qur'an about communication ethics, namely: trustworthy, not lying, and fair. Conflict resolution in realizing a harmonious family in the TKW family in Gajah Village uses four conflict resolutions contained in QS an-Nisa' verse 35, namely: al-Ma'ruf (tenderness and harmony between husband and wife), al-Ma'ruf (tenderness and harmony between husband and wife), al-Sabru (patience), Tahammul al-Ada (freedom in conveying and receiving partner's opinion) and al-Wa'zu (advice).
Flood Inundation Evolution of Barrier Lake and Evaluation of Regional Ecological Spatiotemporal Response -- A Case Study of Sichuan-Tibet Region
Authors: Jiang Fengshan , Dai Xiaoai , Xie Zhiqiang , Xu Tong , Yin Siqiao , Qu Ge , Yang Shouquan , Zhang Yangbin , Yang Zhibing , Xu Jiarui , Hou Zhiqun
Published: December 2021

The Sichuan-Tibet region of China has always been an area with frequent earthquake disasters, accompanied by the occurrence and collapse of dammed lakes. The collapse of dammed lakes seriously threatens the lives and property safety of downstream personnel. At the same time, domestic and foreign scholars are concerned about the surrounding dammed lake there are few ecological studies on the lake, and the impact of the dammed lake on the ecology has very important enlightenment significance for our lake construction project. It is the purpose of this article to scientifically predict the risk of dam break in a barrier lake, explore its impact on the ecological environment and put forward control measures. Based on the four major dammed lake events of Diexihaizi, Tangjiashan dammed lake, and Hongshihe dammed lake in the Sichuan-Tibet area, this paper extracts water bodies from remote sensing images and uses the HEC-RAS model to determine whether there is a risk of the dam break and whether Forecast the route of the dam; and use the InVEST model to evaluate and analyze the habitat of the smallest administrative district (county/district) where it is located from 1990 to 2020 and make an evaluation based on the results of flood inundation. The results show that the stable dammed lake (Diexi Haizi) after engineering treatment has a stabilizing effect on the habitat quality index. The formation of the dammed lake has changed the nearby land-use types and the regional landscape ecological pattern. The habitat quality index will decrease slightly in the 1 km area around Sai Lake, but the habitat quality will increase in the 3 km area and the 5 km area. Artificial flood discharge and engineering reinforcement of barrier lakes are necessary. In this paper, the areas with strong human control will recover better than other regions' habitat quality index.
Encoder Hurwitz Integers: The Hurwitz integers that have the ”division with small remainder” property
Authors: Duram Ramazan , Güzeltepe Murat
Published: December 2021

The residue class set of a Hurwitz integer is constructed by modulo function with primitive Hurwitz integer whose norm is a prime integer, i.e. prime Hurwitz integer. In this study, we consider primitive Hurwitz integer whose norm is both a prime integer and not a prime integer. If the norm of each element of the residue class set of a Hurwitz integer is less than the norm of the primitive Hurwitz integer used to construct the residue class set of the Hurwitz integer, then, the Euclid division algorithm works for this primitive Hurwitz integer. The Euclid division algorithm always works for prime Hurwitz integers. In other words, the prime Hurwitz integers and halves-integer primitive Hurwitz integers have the ”division with small remainder” property. However, this property is ignored in some studies that have a constructed Hurwitz residue class set that lies on primitive Hurwitz integers that their norms are not a prime integer and their components are in integers set. In this study, we solve this problem by defining Hurwitz integers that have the ”division with small remainder” property, namely, encoder Hurwitz integers set. Therefore, we can define appropriate metrics for codes over Lipschitz integers. Especially, Euclidean metric. Also, we investigate the performances of Hurwitz signal constellations (the left residue class set) obtained by modulo function with Hurwitz integers, which have the ”division with small remainder” property, over the additive white Gaussian noise (AWGN) channel by means of the constellation figure of merit (CFM), average energy, and signal-to-noise ratio (SNR).
Human Activity Recognition of Children with Wearable Devices Using LightGBM Machine Learning
Authors: Csizmadia Gábor , Liszkai-Peres Krisztina , Ferdinandy Bence , Miklósi Ádám , Konok Veronika
Published: December 2021

Human activity recognition (HAR) using machine learning (ML) methods is a relatively new method for collecting and analyzing large amounts of human behavioral data using special wearable sensors. Our main goal was to find a reliable method which could automatically detect various playful and daily routine activities in children. We defined 40 activities for ML recognition, and we collected activity motion data by means of wearable smartwatches with a special SensKid software. We analyzed the data of 34 children (19 girls, 15 boys; age range: 6.59 – 8.38; median age = 7.47). All children were typically developing first graders from three elementary schools. The activity recognition was a binary classification task which was evaluated with a Light Gradient Boosted Machine (LGBM)learning algorithm, a decision based method with a 3-fold cross validation. We used the sliding window technique during the signal processing, and we aimed at finding the best window size for the analysis of each behavior element to achieve the most effective settings. Seventeen activities out of 40 were successfully recognized with AUC values above 0.8. The window size had no significant effect. The overall accuracy was 0.95, which is at the top segment of the previously published similar HAR data. In summary, the LGBM is a very promising solution for HAR. In line with previous findings, our results provide a firm basis for a more precise and effective recognition system that can make human behavioral analysis faster and more objective.
Could the candidate causal gene (LZTFL1) identified by Oxford University scientists, which doubles the risk of COVID-19-related respiratory failure, be used to boost the Weak immunogenicity of COVID-19 mRNA vaccines in patients with B-cell chronic lymphocytic leukemia (CLL)???. A double edged sword
Authors: Elkazzaz Mahmoud Ramadan , Abo-Amer Yousry Esam-Eldin , Haydara Tamer , Sarohan Aziz Rodan , Ahmed Amr
Published: December 2021

Patients with B-cell chronic lymphocytic leukemia (CLL) have an increased risk of severe infections due to disease- and treatment-related immunodeficiency. As a result, patients with hematologic malignancies have been given priority for primary COVID-19 vaccination. Unfortunately, many studies have suggested that patients with B-cell chronic lymphocytic leukemia (CLL) who have been fully vaccinated can develop severe and often fatal complications. Therefore, adjuvants that can induce mRNA vaccine efficacy are desperately needed for this category of patients with haematological malignancies. A recent, study by Oxford University scientists showed that leucine zipper transcription factor-like 1(LZTFL1), as a candidate causal gene and its enhancer the rs17713054 A risk allele was significantly responsible for the twofold increased risk of respiratory failure from COVID-19 associated with 3p21.31.By using sequence analysis, the risk allele generates a second CCAAT/enhancer binding protein beta (CEBPB) motif in the enhancer. Moreover, neither LZTFL1 variants found in T cells nor B cells are responsible for increasing death risk from COVID-19 infection according to oxford study. Here, we propose attestable hypothesis that trans retinoic acid could enhance the immune response in vaccinated patients with B-cell chronic lymphocytic leukemia (CLL) according to the recent findings of Oxford scientists by inducing the casual gene(LZTFL1) in CD4 T cells and inhibiting (CEBPB) motif.Conclusions Haematological malignancies (blood cancers) patients are more vulnerable to COVID-19 disuse severity and mortality. Un fortunately mRNA vaccine seem to be less effective with weak immune response and insufficient level of generated antibodies in this category of patients. Therefore we suggest all trans retinoic acid is a good candidate as mRNA COVID-19 vaccine adjuvant via inducing LZTFL1 gene in CD4Tcells and this activation could improve the immune response and increase the level of the generated antibodies. Moreover LZTFL1 gene in CD4 T cells is not associated with increasing risk of COVID-19 infection because of absence of its enhancer(The risk allele of the SNP, rs17713054 A) in immune cells according to oxford recent study. In addition to all trans retinoic acid could inhibit CCAAT/enhancer binding protein beta motif that is generated by The risk allele of the SNP, rs17713054 A
The Proton Pump Inhibitor (Lansoprazole Drug) As a Corrosion Inhibitor for High Carbon Steel in Hydrochloric Acid Solution
Authors: Al-bonayan Ameena M. , El-Hossiany Ahmed , Eid Dalia M. , Fouda Abd El-Aziz S.
Published: December 2021

The proton pump inhibitor lansoprazole (PPIL) drug is examined as corrosion inhibitor for high carbon steel (HCS) dipped in 1.0M HCl. The study was conducted utilizing ac impedance spectroscopy (EIS), Mass loss (Ml), polarization tests, and surface checks were utilized to illustrate the importance of this PPIL extract to the prevent corrosion process for HCS. The influence of temperature and concentration of PPIL on the efficiency of inhibition were tested. The corrosion mechanism occurs, when the PPIL extract molecules block the active center in the electrode surface. The inhibition efficiency (%IF) of HCS occurs by the adsorption procedure and HCS is subject to the adsorption of Langmuir. Polarization curves showed that PPIL drug is a mixed- type inhibitor that retards the dissolution of HCS. IF % was deliberated with altering in the concentration of PPIL various temperature of the medium. From the outcome data we get that the good agreement in the all methods.
Beneficiary Effects of Colchicine on Inflammation and Fibrosis in A Mouse Model of Chronic Kidney Disease
Authors: Landau Daniel , Shukri Nehoray , Arazi Eden , Tobar Ana , Segev Yael
Published: December 2021

Introduction: Low grade inflammation is seen in many chronic illnesses, including chronic kidney disease (CKD). We have recently reported on beneficiary effects of anti-inflammatory treatment in the interleukin (IL-)1 pathway on anemia as well as CKD extent in a mouse model. Colchicine has been shown to have beneficiary effects in several inflammatory conditions through various mechanisms, including inhibition of tubulin polymerization as well as caspase 1 mediated IL1 activation.Methods: CKD was induced by administering an adenine diet to 8-week-old C57BL/6J mice. Mice were treated with colchicine (Col) (30µg/kg) or saline injections for 3 weeks, generating 4 groups: C, C-Col, CKD and CKD-Col.Results: Uremic animals had an increase in inflammation indices in blood (neutrophils), liver and kidneys (p-STAT3, IL-6, SOCS-3). Increased kidney tubulin polymerization and caspase 1 in CKD, as well as kidney Mid88 and IRAK4 (downstream of IL1) were inhibited in CKD-Col. Kidney macrophage infiltration (F4/80 and MAC-2), the percentage of fibrotic area and TGFb mRNA levels were lower in CKD-Col Vs CKD.Conclusions: colchicine improves kidney macrophage infiltration and fibrosis in CKD through inhibition of tubulin polymerization and Caspase 1 activation. Given its reported safety profile for long term anti-inflammatory therapy without increasing infection tendency, it may serve as novel therapeutic approach in CKD.
Serum S100A8/A9 Concentrations are Associated with Neuropsychiatric Involvement and Fatigue in Systemic Lupus Erythematosus: A Cross-Sectional Study
Authors: Zervides Kristoffer A , Jern Andreas , Nystedt Jessika , Gullstrand Birgitta , Nilsson Petra C , Sundgren Pia C , Bengtsson Anders A , Jönsen Andreas
Published: December 2021

Background Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases. We investigated S100A8/A9 in relation to NP-involvement and fatigue in SLE. Methods 72 consecutive SLE outpatients at a tertiary centre and 26 healthy controls were included in this cross-sectional study. NPSLE was determined by specialists in rheumatology and neurology and defined according to three attribution models: “ACR”, “SLICC A” and “SLICC B”. Cerebral MRI was assessed by a neuroradiologist and neurocognitive testing by a neuropsychologist. The individuals were assessed by scores of pain (VAS), fatigue (VAS and FSS), depression (MADRS-S), and health-related life quality (EQ5D). Concentrations of S100A8/A9 in serum and cerebrospinal fluid were measured with ELISA. Statistical calculations were performed using non-parametric methods. Results Serum concentrations of S100A8/A9 were higher in NPSLE patients compared with non-NPSLE patients when applying the ACR and SLICC A models, but not significant when applying the SLICC B model (medians 1400 ng/ml; 920 ng/ml, p=0.011; 1560 ng/ml; 1090 ng/ml, p=0.050; 1460 ng/ml; 1090 ng/ml, p=0.083, respectively). The concentrations were higher in SLE patients compared with controls (medians 1230 ng/ml; 790 ng/ml, p=0.023). No differences of CSF S100A8/A9 concentrations were observed between NPSLE and non-NPSLE patients. SLE patients with depression or cognitive dysfunction as an ACR NPSLE manifestation had higher serum S100A8/A9 concentrations than non-NPSLE patients (median 1460 ng/ml, p=0.007 and 1380 ng/ml, p=0.013, respectively). Higher serum S100A8/A9 correlated with higher VAS fatigue (r=0.31; p=0.008), VAS pain (r=0.27, p=0.021), and lower EQ5D (r=-0.29, p=0.014) in SLE patients. NPSLE was associated with higher plasma CRP concentrations, higher scores of fatigue and pain, lower EQ5D, and fewer weekly work hours. Serum S100A8/A9 was not independently associated with NPSLE when adjusting for plasma CRP, and scores of fatigue (FSS) and pain (VAS), (OR 1.70, 95% CI 0.82-3.53, p=0.15). Conclusions Serum S100A8/A9 concentrations may be associated with NPSLE and fatigue. S100A8/A9 may be of interest in evaluating NPSLE, although further investigations are needed.
An Evidence-based General Anesthesia and Prone Position Nursing Checklist: Development and Testing
Authors: Cai Jianshu , Huang Xiaoling , He Lifang
Published: December 2021

Background and Aim: Prone positioning during general anesthesia is one of the most difficult practices for the perioperative nurse. Patients in this position are vulnerable to many preventable complications. However, no studies have developed an evidenced-based tool to improve nursing practice during general anesthesia and prone positioning. This study aimed to develop and test a general anesthesia and prone position nursing checklist for use by the circulating nurse. Methods: The WHO checklist development model and evidence-based methods guided the checklist development process. A prospective pre-post study was performed between November 2020 and March 2021. We prospectively observed circulating nurses that attended to prone general anesthesia during posterior lumbar spine surgery for three months before and after the introduction of the general anesthesia and prone position nursing risk checklist. The main outcomes were successful delivery of essential prone positional nursing practices during each surgery and the nurse's opinion of the checklist’s efficacy and utility. Results: A general anesthesia and prone position nursing checklist comprised of 4 pause points and 22 necessary nursing practices was developed. Seventy-two nurses participated in this study. Use of the checklist significantly increased the average performance of essential practices during each surgery from 72.72% to 95.45%. Three measures had a compliance rate of 100%. The delivery rate of 14 measures was significantly improved, 91.7% of nurses considered the checklist easy to use, and 94.4% nurses would want the checklist to be used if they underwent a prone position and general anesthesia operation. Conclusions: A general anesthesia and prone position nursing checklist was developed. The instrument was found to be an effective and positively received tool for facilitating key measures of prone positioning during nursing care, translating evidence into practice, and standardizing the nursing process.
Endoscopic Ultrasound Miniprobe and Single Balloon Enteroscopy: A Diagnostic Tool for Investigating Small Bowel Lesions
Authors: Cannizzaro Renato , Magris Raffaella , Maiero Stefania , Navarria Luca , Fornasarig Mara
Published: December 2021

Objectives: The set of balloon-assisted enteroscopy and endoscopic ultrasonography (EUS) together can further improve the diagnosis of small bowel submucosal lesions. We reported our experience on clinical utility of the EUS miniprobe UM-3Y in the investigation of lesions of small bowel during single balloon enteroscopy (SBE). Methods: Between 2014 and 2017 we investigated 14 consecutive patients with symptoms, the suspect of small bowel tumor or inflammatory bowel disease. Almost all patients underwent video-capsule endoscopy before SBE. Results: EUS permitted us to better characterize lesions detected with SBE procedure with no complications and it permitted to exclude the presence of lesions in some doubtful cases.Conclusions: Our data demonstrated that EUS with miniprobe UM-3Y, associated with SBE, is an important diagnostic tool for investigating, with high accuracy, small bowel lesions. This can let to establish a better management of small bowel lesions.
An Exploration of Trifluridine/Tipiracil in Combination with Irinotecan in Patients with Pretreated Advanced Gastric Cancer
Authors: Mizukami Takuro , Minashi Keiko , Hara Hiroki , Nishina Tomohiro , Amanuma Yusuke , Takahashi Naoki , Nakasya Akio , Takahashi Masaki , Nakajima Takako Eguchi
Published: December 2021

Background: Trifluridine/tipiracil (FTD/TPI) and irinotecan are treatment options for heavily pretreated patients with advanced gastric cancer but with limited efficacies. We investigated the combination of FTD/TPI and irinotecan for such patients.Methods: Patients who refractory to fluoropyrimidine, platinum and taxane were enrolled into four cohorts (Level 1A/1B/2A/2B) used an escalated dose of irinotecan [100 (Level 1) or 125 mg/m2 (Level 2) on days 1 and 15] with 2 schedules of FTD/TPI 35 mg/m2/dose: twice daily, on days 1-5 and 8-12 (Level A) or on days 1-5 and days 15-19 (Level B) of a 28-day cycle. The primary and secondary objectives were determination of maximum tolerated dose, dose-limiting toxicities (DLTs), and recommended phase II dose (RP2D) , and evaluation of disease control rate (DCR), respectively. Results: Eleven patients were enrolled; 2 at Level 1A, 3 at Level 1B and 6 at Level 2B. DLTs occurred in 2/2 patient at Level 1A, and 2/6 patients at Level 2B. Grade 3 or higher treatment-related adverse events were neutropenia (90.9%), leukopenia (54.5%), anemia (45.5%) and febrile neutropenia (18.2%). One patient at Level 2B achieved partial response and the DCR was 72.7% (95% CI 39.0- 94.0%). The median progression-free survival and overall survival was 3.0 months (95% CI 0.92- not reached) and 10.2 months (95% CI 2.2- not reached), respectively.Conclusion: The RP2D of FTD/TPI combined with irinotecan was determined to be Level 1B with manageable hematologic toxicities and feasible non-hematologic toxicities. Further evaluation for its efficacy in the RP2D is necessary. Mini-abstract: A phases Ib study of trifluridine/tipiracil in combination with irinotecan for advanced gastric cancer determined the recommended dose with manageable hematologic toxicities and feasible non-hematologic toxicities.
Plagued by a cryptic clock: Insight and issues from the global phylogeny of Yersinia pestis
Authors: Eaton Katherine , Featherstone Leo , Duchene Sebastian , Carmichael Ann , Varlık Nükhet , Golding Brian , Holmes Edward , Poinar Hendrik
Published: December 2021

Plague has an enigmatic history as a zoonotic pathogen. This potentially devastating infectious disease will unexpectedly appear in human populations and disappear just as suddenly. As a result, a long-standing line of inquiry has been to estimate when and where plague appeared in the past. However, there have been significant disparities between phylogenetic studies of the causative bacterium, Yersinia pestis, regarding the timing and geographic origins of its reemergence. Here, we curate and contextualize an updated phylogeny of Y. pestis using 601 genome sequences sampled globally. We perform a detailed Bayesian evaluation of temporal signal in subsets of these data and demonstrate that a Y. pestis-wide molecular clock model is unstable. To resolve this, we devised a new approach in which each Y. pestis population was assessed independently. This enabled us to recover significant temporal signal in five populations, including the ancient pandemic lineages which we now estimate may have emerged decades, or even centuries, before a pandemic was historically documented from European sources. Despite this, we only obtain robust divergence dates from populations sampled over a period of at least 90 years, indicating that genetic evidence alone is insufficient for accurately reconstructing the timing and spread of short-term plague epidemics. Finally, we identify key historical data sets that can be used in future research, which will complement the strengths and mitigate the weaknesses of genomic data.
Novel Greener Microwave-Assisted Deprotection Methodology for the 1,3-Dioxolane Ketal of Isatin Using Calix[n]arenes
Authors: Barbosa Lucas , da Silva Tiago , Rezende Michelle , da Silva Bianca , Guzzo Rodrigo , Silva Bárbara
Published: December 2021

In this work, the combined use of p-sulfonic acid-calix[n]arene and microwave energy to hydrolyze the 1,3-dioxolane ketal of isatin was evaluated with excellent results. This is the first time that p-sulfonic acid-calix[n]arene has been used as the catalyst in a ketal hydrolysis reaction and the deprotection of the ketone carbonyl of isatin is reported. The presence of 2.5 mol% of p-sulfonic acid-calix[4,6]arene at 160 ºC resulted in over 96% conversion of this ketal in 10 min, with the additional advantage of using water as a solvent. This catalytic system (aqueous phase containing p-sulfonic acid-calix[4]arene) was reused for five consecutive cycles, with a conversion above 96% maintained. This reusable system is not practicable using p-toluenesulfonic acid and p-hydroxybenzenesulfonic acid as catalysts since both are extracted to the organic phase with the reaction product. The hydrolysis of 1,3-dioxolane ketal of isatins with different substituents (CH3, I, Br, Cl, F, NO2) in the aromatic ring was also evaluated. The protecting group of 5-methyl-isatin was removed with 73% conversion using 2.5 mol% of p-sulfonic acid-calix[4]arene at 160 ºC for 5 min. In contrast, the ketal of 5-nitro-isatin reached 80% conversion using the same conditions after 40 min.
EDUCAÇÃO POPULAR EM SAÚDE E LUTA POR DIREITOS SOCIAIS: UMA ANÁLISE DA EXPERIÊNCIA DE ESTÁGIO EM SERVIÇO SOCIAL NO HOSPITAL MS. WALFREDO GURGEL/RN
Authors: Caroline Amanda da Fé Pereira , Taynara Marcella Andrade da Silva , Lima Tibério Oliveira
Published: December 2021

O trabalho trata de uma análise acerca da experiência de estágio curricular vivenciada no Hospital Ms. Walfredo Gurgel da cidade de Natal/RN, relacionando com o projeto de intervenção realizado durante o ano de 2017. O estudo se refere às disciplinas de Estágio em Serviço Social I e II e Núcleo do fazer profissional I e II. O objetivo do trabalho constitui em apresentar uma breve explanação da concepção de estágio vivenciada no espaço sócio ocupacional, contextualizando de forma crítica a conjuntura da realidade atual, além da elaboração e materialização do projeto de intervenção no Hospital Ms. Walfredo Gurgel com os usuários que acessam a instituição. A metodologia foi construída a partir do aporte teórico com a pesquisa bibliográfica, além de rodas de conversas utilizadas com os usuários do serviço e formas de avaliação do conteúdo. Os conteúdos abordados se referem à Lei 13.429/2017 e a Emenda Constitucional 95/2016,relacionando com o âmbito da saúde e recortando para o hospital. Percebemos que existem possibilidades de realização de atividades voltadas para educação em saúde e ações sócio pedagógicas, na perspectiva de trazer para esses sujeitos acesso a informações sobre assistência social e direitos sociais, além de possibilitar a participação social.