bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures
Authors: Vörösházi Júlia , Mackei Máté , Sebők Csilla , Tráj Patrik , Márton Rege Anna , Horváth Dávid Géza , Huber Korinna , Neogrády Zsuzsanna , Mátis Gábor
Published: January 2024

Despite being one of the most common contaminants of poultry feed, the molecular effects of T-2 toxin on the liver of the exposed animals are still not fully elucidated. To gain more accurate understanding, the effects of T-2 toxin were investigated in the present study in chicken-derived three-dimensional (3D) primary hepatic cell cultures. 3D spheroids were treated with three concentrations (100, 500, 1000 nM) of T-2 toxin for 24 h. Cellular metabolic activity declined in all treated groups as reflected by the Cell Counting Kit-8 assay, while extracellular lactate dehydrogenase activity was increased after 500 nM T-2 toxin exposure. The levels of oxidative stress markers malondialdehyde and protein carbonyl were reduced by the toxin, suggesting effective antioxidant compensatory mechanisms of the liver. Concerning the pro-inflammatory cytokines, IL-6 concentration was decreased, while IL-8 concentration was increased by 100 nM T-2 toxin exposure, indicating the multifaceted immunomodulatory action of the toxin. Further, the metabolic profile of hepatic spheroids was also modulated, confirming the altered lipid and amino acid metabolism of toxin-exposed liver cells. Based on these results, T-2 toxin affected cell viability, hepatocellular metabolism and inflammatory response, likely carried out its toxic effects by affecting the oxidative homeostasis of the cells.
Evaluation of precipitation across the contiguous United States, Alaska, and Puerto Rico in multi-decadal convection-permitting simulations
Authors: Akinsanola Akintomide Afolayan , Jung Chunyong , Wang Jiali , Kotamarthi Veerabhadra Rao
Published: January 2024

This study is an early effort to generate a multi-decadal convection-permitting regional climate dataset that covers nearly the entire North American continent. We assessed a 20 year dynamically downscaled regional climate simulation at a 4 km spatial resolution with explicit convection across the contiguous United States (CONUS), Alaska, and Puerto Rico. Specifically, we evaluated the model’s performance in representing mean, 95th percentile, and extreme precipitation across regions. Our findings indicate that when compared with ERA5 reanalysis, the forcing data, convection-permitting simulation improves representations of seasonal, 95th percentile, and extreme precipitation over a large portion of the CONUS, Alaska, and Puerto Rico, particularly in areas where precipitation is heaviest. The simulation adds value over its forcing data (ERA5) in up to 53% of all grid cells in the CONUS, 68.8% in Alaska, and 84.0% in Puerto Rico. It is important to note that, however, despite improvements, model errors in Puerto Rico remain large. Similar improvements are observed in extreme indices, including consecutive dry days, maximum 5 days precipitation, and extreme precipitation. Analysis of the diurnal cycle of mean hourly precipitation suggests that representations of convective processes—including onset, dissipation, suppression, downstream propagation, and local circulation—improved overall.
Clinical role of pretreatment albumin-to-alkaline phosphatase ratio in lung cancer: a meta-analysis
Authors: Yang Yanhui , Wang Yi , Li Xiaoliang , Xie Xiaoyang
Published: January 2024

The association between pretreatment albumin-to-alkaline phosphatase ratio (AAPR) and clinicopathological parameters and prognosis in lung cancer is unclear. The study aimed to identify the clinical role of pretreatment AAPR among lung cancer patients. Several databases were searched for relevant studies. The primary outcome and secondary outcome were long-term survival including the overall survival (OS) and progression-free survival (PFS) and clinicopathological characteristics, respectively. The hazard ratios (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were combined. A total of 11 publications involving 10,589 participants were included in this meta-analysis. The pooled results manifested that a lower pretreatment AAPR predicted poorer OS (HR = 0.65, 95% CI 0.59–0.71, P < 0.001) and PFS (HR = 0.68, 95% CI 0.59–0.78, P < 0.001). Furthermore, subgroup analysis for the OS and PFS based on the pathological type and treatment showed similar results and pretreatment AAPR was significantly associated with worse prognosis. Besides, pretreatment AAPR was significantly associated with male (RR = 1.08, 95% CI 1.03–1.13, P < 0.001), poor differentiation (RR = 1.33, 95% CI 1.03–1.73, P = 0.029), advanced T stage (RR = 1.25, 95% CI 1.03–1.52, P = 0.026), N stage (RR = 1.34, 95% CI 1.15–1.55, P < 0.001) and TNM stage (RR = 1.14, 95% CI 1.06–1.223, P < 0.001). Therefore, pretreatment AAPR is significantly related to prognosis and tumor stage in lung cancer and patients with a lower pretreatment AAPR are more likely to experience poor survival and advanced tumor stage.
Introducing a new approach for modeling a given time series based on attributing any random variation to a jump event: jump-jump modeling
Authors: Movahed Ali Asghar , Noshad Houshyar
Published: January 2024

When analyzing the data sampled at discrete times, one encounters successive discontinuities in the trajectory of the sampled time series, even if the underlying path is continuous. On the other hand, the distinction between discontinuities caused by finite sampling of continuous stochastic process and real discontinuities in the sample path is one of the main problems. Clues like these led us to the question: Is it possible to provide a model that treats any random variation in the data set as a jump event, regardless of whether the given time series is classified as diffusion or jump-diffusion processes? To address this question, we wrote a new stochastic dynamical equation, which includes a drift term and a combination of Poisson jump processes with different distributed sizes. In this article, we first introduce this equation in its simplest form including a drift term and a jump process, and show that such a jump-drift equation is able to describe the discrete time evolution of a diffusion process. Afterwards, we extend the modeling by considering more jump processes in the equation, which can be used to model complex systems with various distributed amplitudes. At each step, we also show that all the unknown functions and parameters required for modeling can be obtained non-parametrically from the measured time series.
Identifying Spatial Co-occurrence in Healthy and InflAmed tissues (ISCHIA)
Authors: Lafzi Atefeh , Borrelli Costanza , Baghai Sain Simona , Bach Karsten , Kretz Jonas A , Handler Kristina , Regan-Komito Daniel , Ficht Xenia , Frei Andreas , Moor Andreas
Published: January 2024

Sequencing-based spatial transcriptomics (ST) methods allow unbiased capturing of RNA molecules at barcoded spots, charting the distribution and localization of cell types and transcripts across a tissue. While the coarse resolution of these techniques is considered a disadvantage, we argue that the inherent proximity of transcriptomes captured on spots can be leveraged to reconstruct cellular networks. To this end, we developed ISCHIA (Identifying Spatial Co-occurrence in Healthy and InflAmed tissues), a computational framework to analyze the spatial co-occurrence of cell types and transcript species within spots. Co-occurrence analysis is complementary to differential gene expression, as it does not depend on the abundance of a given cell type or on the transcript expression levels, but rather on their spatial association in the tissue. We applied ISCHIA to analyze co-occurrence of cell types, ligands and receptors in a Visium dataset of human ulcerative colitis patients, and validated our findings at single-cell resolution on matched hybridization-based data. We uncover inflammation-induced cellular networks involving M cell and fibroblasts, as well as ligand-receptor interactions enriched in the inflamed human colon, and their associated gene signatures. Our results highlight the hypothesis-generating power and broad applicability of co-occurrence analysis on spatial transcriptomics data.
Transformation of nanoparticles via the transition of functional DNAs responsive to pH and vascular endothelial growth factor for photothermal anti-tumor therapy
Authors: Kim Jinseong , Nah Yunyoung , Kim Seongmin , Kim Won Jong
Published: January 2024

This study introduces a novel approach for developing DNA-functionalized gold nanoparticles (AuNPs) that respond to disease-specific factors and microenvironmental changes, achieving an effective anti-tumor effect through photothermal therapy.
Selective grain boundary passivation by ammonium nitrate for enhanced performance and stability of FA-Cs based perovskite solar cells
Authors: Li Xiaoshan , Yu Wenjing , Hou Tian , Yang Xin , Wang Xin , Jiang Guangmian , Fu Zhipeng , Chen Kaipeng , Li Yanlin , Yang Chengbin , Sun Xiaoran , Zhang Meng
Published: January 2024

Ammonium nitrate can be used for selective grain boundary passivation of FA-Cs based perovskite thin films and solar cells.
A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent
Authors: Nogita Kohei , Sugahara Takaya , Miki Koji , Mu Huiying , Kobayashi Minoru , Harada Hiroshi , Ohe Kouichi
Published: January 2024

This manuscript describes the biological thiol-mediated reductive transformation of an MPc precursor under physiological conditions and its application to PA imaging.
Enhanced inverted singlet–triplet gaps in azaphenalenes and non-alternant hydrocarbons
Authors: Garner Marc H. , Blaskovits J. Terence , Corminboeuf Clémence
Published: January 2024

A substituent-based design strategy induces and enhances inversions in the excited state singlet–triplet gaps in a wide range of potential organic light-emitting molecules.
Exploring 0D lead-free metal halide with highly efficient blue light emission and high-sensitivity photodetection
Authors: Wang Yu-Yin , Kang Huai-Yuan , Zhang Shao-Ya , Qu Hao , Zhu Lin , Zhao Dan , Li Xian-Feng , Lei Xiao-Wu , Yue Cheng-Yang
Published: January 2024

A new 0D lead-free metal halide of (F-PPA)ZnBr4 with narrow blue emission, high PLQY, high stability and high detection sensitivity to UV light was synthesized and measured.
Molybdenum-doped Co3S4 nanoarrays as outstanding catalysts for overall water splitting
Authors: Zhai Yanshui , Cai Linjun , Gong Zhikun , Hu Wenzhuo , Li Zhimei
Published: January 2024

Developing cobalt-based electrocatalysts that can replace precious metals is significant for hydrogen production in water splitting, however, this is still a complex and demanding task.
Radiolytic evaluation of a new technetium redox control reagent for advanced used nuclear fuel separations
Authors: Dang Anh N. , Rogalski Maya H. , Pilgrim Corey D. , Wilbanks Joseph R. , Peterman Dean R. , Carrie Jesse D. , Zalupski Peter R. , Mezyk Stephen P. , Horne Gregory P.
Published: January 2024

Steady-state and time-resolved irradiations of diaminoguanidine have shown that the longevity of this potential TcO4− redox control reagent will be limited by its reaction with nitrous acid and oxidizing radicals from nitric acid radiolysis.
Insights into electron dynamics in two-dimensional bismuth oxyselenide: a monolayer-bilayer perspective
Authors: Chen Cuifan , Yang Zhi , Liu Ruiping , Xue Lin , Xu Li-Chun
Published: January 2024

There is a two-stage hot-electron relaxation process—initially fast followed by slow—in both monolayer and bilayer Bi2O2Se within the conduction band, and the monolayer displays a shorter relaxation time.
Graphene-based multifunctional humidity sensors with an ultrahigh current response
Authors: Antonova Irina V. , Poteryayev Dmitriy A. , Ivanov Artem I. , Nebogatikova Nadezhda A. , Shavelkina Marina B.
Published: January 2024

The graphene:PEDOT:PSS flexible sensors able to operate as the humidity sensors, the human breath sensors and touch sensors.
Diversity of protonated mixed pyrene–water clusters investigated by collision induced dissociation
Authors: M. Nair Arya , Leboucher Héloïse , Toucouere Lorris , Zamith Sébastien , Joblin Christine , L'Hermite Jean-Marc , Marciniak Alexandre , Simon Aude
Published: January 2024

Protonated mixed pyrene–water clusters, (Py)m(H2O)n H+, where m = [1–3] and n = [1–10], are generated using a cryogenic molecular cluster source. Collision induced dissociation is employed to explore the proton localisation in these systems.
Comparing the net-energy balance of standalone photovoltaic-coupled electrolysis and photoelectrochemical hydrogen production
Authors: Tam Brian , Babacan Oytun , Kafizas Andreas , Nelson Jenny
Published: January 2024

Photovoltaic-coupled electrolysis and photoelectrochemical water splitting are two options for storing solar energy as hydrogen. For each technology, the energy inputs and hydrogen output need to be considered to compare the overall energy balance.
Quantitative analysis of sodium metal deposition and interphase in Na metal batteries
Authors: Sayahpour Baharak , Li Weikang , Bai Shuang , Lu Bingyu , Han Bing , Chen Yu-Ting , Deysher Grayson , Parab Saurabh , Ridley Phillip , Raghavendran Ganesh , Nguyen Long Hoang Bao , Zhang Minghao , Meng Ying Shirley
Published: January 2024

Sodium-ion batteries exhibit significant promise as a viable alternative to current lithium-ion technologies owing to their sustainability, low cost per energy density, reliability, and safety.
Enhancing the inherent stability of perovskite solar cells through chalcogenide-halide combinations
Authors: Wang Cheng , Nie Riming , Dai Yiming , Tai Huanyu , Zhu Bingjian , Zhao Luyao , Wu Yong , Guo Wanlin , Seok Sang Il
Published: January 2024

Perovskite solar cells have attracted much attention due to their rapidly increasing power conversion efficiency, however, their poor inherent long-term stability limits their commercialization.
Surface ion-activated polymer composite dielectrics for superior high-temperature capacitive energy storage
Authors: Yang Minhao , Zhao Yanlong , Wang Zepeng , Yan Huarui , Liu Zeren , Li Qi , Dang Zhi-Min
Published: January 2024

The construction of a negatively charged layer on the surface of polymer composite dielectric can significantly suppress the conduction loss at high temperatures and electric fields, consequently contributing to the improvement in the capacitive energy storage performance.
Constructing highly durable reversal-tolerant anodes via integrating high-surface-area Ti4O7 supported Pt and Ir@IrOx for proton exchange membrane fuel cells
Authors: Li Zheng , Mu Yongbiao , Zhang Qing , Huang Haodong , Wei Xianbin , Yang Lin , Wang Guanxiong , Zhao Tianshou , Wu Gang , Zeng Lin
Published: January 2024

A robust core–shell Ir@IrOx/Pt/Ti4O7 catalyst was developed as a reversal-tolerant anode with high reversal tolerance, slow degradation, and low cost during the anode reversal.
Advanced design strategies for Fe-based metal–organic framework-derived electrocatalysts toward high-performance Zn–air batteries
Authors: Guo Ya-Fei , Zhao Shan , Zhang Nan , Liu Zong-Lin , Wang Peng-Fei , Zhang Jun-Hong , Xie Ying , Yi Ting-Feng
Published: January 2024

This article summarizes the regulation strategies of Fe-based MOFs-derived electrocatalysts for ZABs, and provides a prospect for their future development.
Similarity of multicomponent nanomaterials in a safer-by-design context: the case of core–shell quantum dots
Authors: Di Battista Veronica , Sanchez-Lievanos Karla R. , Jeliazkova Nina , Murphy Fiona , Tsiliki Georgia , Zabeo Alex , Gajewicz-Skretna Agnieszka , Mikołajczyk Alicja , Hristozov Danail , Stone Vicki , Schmid Otmar , Hunt Neil , Oomen Agnes G. , Wohlleben Wendel
Published: January 2024

Concepts of similarity applied to complex multicomponent advanced materials for an informed balance of performance and hazard.
Evidence-based framework to use in situ phycocyanin readings for cyanobacterial risk assessment within drinking water treatment plants
Authors: Ma Liya , Dorner Sarah , Prévost Michèle
Published: January 2024

A framework is proposed using multi-stream phycocyanin probe readings to manage cyanobacterial risks at the source water and across the drinking water treatment processes.
In silico prediction aided preparation of antioxidant soybean peptides by enzymatic hydrolysis for ameliorating lead exposure-induced toxicity
Authors: Ju Yaojun , Bu Dingdong , Wang Haozhe , Li Bingye , Cheng Dai
Published: January 2024

Antioxidant soybean peptides prepared with the optimized enzymatic hydrolysis process aided by in silico prediction can protetect against Pb toxicity.
Plant-based hydrocolloids for efficient clarification of cane juices: rheological analysis and solidification studies
Authors: T. Venkatesh , George Alphonsa , Kesav S. Rishi , M. S. Sajeev , Kothakota Anjineyulu
Published: January 2024

Clarification of sugarcane juices is carried out with plant-based hydrocolloids such as Xanthan gum, guar gum & starch. Starch is identified as the most effective clarifying agent. Sugars produced by starch clarification showed superior properties.
Introducing “time-of-flight single particle investigator” (TOF-SPI): a tool for quantitative spICP-TOFMS data analysis
Authors: Gundlach-Graham Alex , Harycki Stasia , Szakas Sarah E. , Taylor Tristen L. , Karkee Hark , Buckman Raven L. , Mukta Shahnaz , Hu Rui , Lee Woolin
Published: January 2024

TOF-SPI is software for accurate, robust, and high-throughput analysis of single-particle ICP-TOFMS data.
High sensitivity and automatic chemiluminescence detection of glucose and lactate using a spin-disc paper-based device
Authors: Tong Wenqiang , Shi Jiaming , Yu Zhihang , Ran Bin , Chen Huaying , Zhu Yonggang
Published: January 2024

This paper reports a spin-disc paper-based device with 10 individual detection units containing electromagnetic modules controlling the sample incubation time before chemiluminescence (CL) signal detection.
Understanding the role of aliovalent cation substitution on the li-ion diffusion mechanism in Li6+xP1−xSixS5Br argyrodites
Authors: Schwietert Tammo K. , Gautam Ajay , Lavrinenko Anastasia K. , Drost David , Famprikis Theodosios , Wagemaker Marnix , Vasileiadis Alexandros
Published: January 2024

The Si-induced uniform Li distribution enhances intercage diffusion, enabled through the T4 interstitial positions, resulting in increased macroscopic diffusion and ionic conductivity.
Porous microwell scaffolds for 3D culture of pancreatic beta cells to promote cell aggregation and insulin secretion
Authors: Chen Huajian , Zeng Tianjiao , Yoshitomi Toru , Kawazoe Naoki , Komatsu Hirotake , Yang Yingnan , Chen Guoping
Published: January 2024

Porous microwell scaffolds of biodegradable polymers of gelatin and poly(lactic-co-glycolic acid) (PLGA) were prepared for 3D culture of pancreatic beta cells to promote the formation of cell aggregates and insulin secretion.
Tetrahedron clusters serving as a platform for foam-like structure design
Authors: Jenczyk Jacek
Published: January 2024

There are a number of exceptional examples indicating the unique position of tetrahedral symmetry in the vast landscape of different spatial organization pathways which can be sampled by matter.
Safe nanomaterials: from their use, application, and disposal to regulations
Authors: Chávez-Hernández Jorge Antonio , Velarde-Salcedo Aída Jimena , Navarro-Tovar Gabriela , Gonzalez Carmen
Published: January 2024

Nanotechnology is a relatively new technological field, therefore, the information about the associated risk of nanomaterials in environmental and human health must be addressed and consolidated to develop accurate legislations, frameworks, and guidelines to standardise a safe use in any field.
CBe4H6: a molecular rotor with a built-in on–off switch
Authors: Jin Bo , Yuan Caixia , Guo Jin-Chang , Wu Yan-Bo
Published: January 2024

CBe4H6 is a molecular rotor with a C–H bond as on-off switch, the temperature-dependent equatorial and axial configurations of the C–H bond can stop and resume rotation, respectively, by destroying and restoring its central delocalized σ bonds.
In situ construction of a continuous ionic conductive coating for a high-performance Li3VO4 anode
Authors: Wang Lulu , Zheng Ceng , Liang Jianing , Zhai Chun , Liu Hao , Zhai Tianyou , Li Huiqiao
Published: January 2024

An organic interface nanolayer is effectively coated on the LVO nanoparticle surface by an in situ solid–liquid chemical reaction for high Li-ion storage performance.
AIE-active cyclometalated iridium(iii) complexes for highly efficient picric acid detection in aqueous media
Authors: Rabha Monosh , Lyngkhoi Deikrisha Lyngdoh , Patra Sumit Kumar , Khatua Snehadrinarayan
Published: January 2024

Three Ir(iii) complex-based AIEgens have been developed to detect picric acid efficiently in aqueous solution. The bright emission of these complexes in the aggregated and crystalline states is supported by crystal structure and triplet state TDDFT study.
3D defect-enriched Cu/Cu2O–Al2O3 zigzag nanostructures for efficient degradation of tetracycline antibiotics
Authors: Wu Dandan , Wu Jicheng , Fu Lin , Jia Runping , Wu Qingsheng , Zhu Yuanzheng , Zhou Tao , Han Sheng , Wen Ming
Published: January 2024

Defect-enriched Cu/Cu2O–Al2O3 nanoribbons with zigzag edges have been prepared and they exhibit superior degradation efficiency on tetracycline antibiotics, due to their better oxygen adsorption and capture ability.
Molecular dynamics simulations of aggregation and viscosity properties of model asphaltene molecules containing a polycyclic hydrocarbon nucleus with toluene additive under shear interactions
Authors: Peng Baoliang , Yuan Lingfang , Tang Xianqiong , Wang Yao , Li Yingying , Liu Weidong , Pei Yong
Published: January 2024

Molecular dynamics (MD) simulations were carried out to study the aggregation behavior and viscosity properties of 15 structurally homologous model asphaltene molecules under shear conditions and with a toluene additive with different concentrations.
Novel applications of photobiocatalysts in chemical transformations
Authors: Singh Praveen P. , Sinha Surabhi , Nainwal Pankaj , Singh Pravin K. , Srivastava Vishal
Published: January 2024

Photocatalysis has proven to be an effective approach for the production of reactive intermediates under moderate reaction conditions.
Two-photon excited luminescence of sulfur quantum dots for heavy metal ion detection
Authors: Siomra Agnieszka , Wawrzyńczyk Dominika , Samoć Marek , Nyk Marcin
Published: January 2024

Spectrally-resolved third-order nonlinear optical properties of water-dispersed sulfur quantum dots were used as combined one- and two-photon active sensor for heavy metal ions detection.
Late-stage gem-difluoroallylation of phenol in bioactive molecules and peptides with 3,3-difluoroallyl sulfonium salts
Authors: Zhou Minqi , Ren Jin-Xiu , Feng Xiao-Tian , Zhao Hai-Yang , Fu Xia-Ping , Min Qiao-Qiao , Zhang Xingang
Published: January 2024

An efficient method for the late-stage selective O-fluoroalkylation of tyrosine residues with 3,3-difluoroallyl sulfonium salts (DFASs) has been developed. The added functional groups from DFASs can serve as linkers for successive modifications.
Evidence for Suzuki–Miyaura cross-couplings catalyzed by ligated Pd3-clusters: from cradle to grave
Authors: Jeddi Neda , Scott Neil W. J. , Tanner Theo , Beaumont Simon K. , Fairlamb Ian J. S.
Published: January 2024

Pdn clusters offer unique selectivity and exploitable reactivity in catalysis. Tethering Pd3 clusters to a resin unlocks compelling new insight into the speciation of Pd during catalytic turnover for Suzuki–Miyaura cross-couplings.
Ultra-effective room temperature gas discrimination based on monolithic Pd@MOF-derived porous nanocomposites: an exclusive scheme with photoexcitation
Authors: Duan Peiyu , Wang Haowen , Peng Qingkui , Chen Shiyao , Zhou Hongmin , Duan Qiangling , Jin Kaiqiang , Sun Jinhua
Published: January 2024

A high-selectivity reversed response to H2 is discovered from the monolithic MOF-derived nanocomposites under UV photoexcitation at room-temperature, which provides a feasible reference for the ultra-effective gas discrimination at room temperature.
Progresses on high-entropy nano-catalysts for electrochemical energy conversion reactions
Authors: Zhang Lihua , Wu Tong , Zhan Yinbo , Dong Yilin , Wei Fei , Zhang Dongliang , Zhou Bowei , Tan Zheng , Zhao Changying , Long Xia
Published: January 2024

This review provides a comprehensive discussion of the recent progresses of nanostructured HEMs as electrocatalysts for energy conversion reactions, with emphasis on the structure–composition–property–performance relationship of the HEMs.
Boosting electrocatalytic hydrogen evolution over a Mo2C–W2C heterostructure by interface-induced electron modulation
Authors: Jiang Lijuan , Wang Ruijing , Zhou Huimin , Wei Guang-Feng , Wang Xuefeng
Published: January 2024

The Mo2C–W2C interface induces electron modulation which promotes hydrogen desorption and enhances HER activity.
Liver fibrosis: pathological features, clinical treatment and application of therapeutic nanoagents
Authors: Chen Lin , Guo Wenyan , Mao Chun , Shen Jian , Wan Mimi
Published: January 2024

Pathological features of liver fibrosis, clinical treatment and application of therapeutic nanoagents for liver fibrosis.
The line defects in two-dimensional Bi2O2S: enhanced photocurrents in the infrared region
Authors: He Yaoyu , Hu Wenhui , Yang Zhi , Xu Li-Chun , Xue Lin , Liu Ruiping , Liu Xuguang
Published: January 2024

The line defects in 2D Bi2O2S can lead to typical metallized phenomena or tunable band gaps, and some line defects have rich photoelectronic properties such as the enhanced photocurrent in the infrared region.
Acid–base regulated inclusion complexes of β-cyclodextrin with 1-[2-(4-fluorophenyl)-2-oxoethyl]-4,4′-bipyridinium dichloride displaying multistimuli-responsive chromic behaviors and photomodulable fluorescence
Authors: Wang Xiao-Feng , Xu Chen-Yan , Lin Rui-Lian , Sun Wen-Qi , Ye Ming-Fu , Xu Li-Xin , Liu Jing-Xin
Published: January 2024

Two inclusion complexes of β-cyclodextrin with a viologen derivative display multistimuli-responsive chromic behaviors and photomodulable fluorescence, which endows them with various applications.
Patient Characteristics and Treatment Patterns for Speech-Language Pathology Services in Skilled Nursing Facilities
Authors: Brown Cait , Prusynski Rachel , Baylor Carolyn , Humbert Andrew , Mroz Tracy M.
Published: January 2024

Purpose:

Skilled nursing facility (SNF) care has historically been influenced by systemic issues that could impact speech-language pathology (SLP) service provision. However, there has been little study specifically on factors associated with SLP service provision in SNFs. Large administrative data sets are rarely analyzed in SLP research but can be used to understand real-world SLP services. This study investigated associations between patient and facility characteristics and SLP services.

Method:

Mixed-effects logistic regression models were used to evaluate factors associated with SLP service provision in 2018 Medicare administrative data representing 833,653 beneficiaries.

Results:

Beneficiaries had higher odds of receiving SLP services when they had neurologic diagnosis (odds ratio [OR] = 3.32), had SLP-related functional impairments (ORs = 1.19–3.41), and received other rehabilitative services (ORs = 3.11–3.78). Beneficiaries had lower odds of receiving SLP services when they received care from SNFs located in hospitals versus freestanding (OR = 0.45), with need for interpreter services (OR = 0.76) and with thresholding (OR = 0.68), a financially motivated practice. Direction of association varied across racial and ethnic groups and measures of location. Odds of being provided SLP services decreased with increasing communication impairment severity.

Conclusions:

The results suggest that clinicians are identifying patients with diagnoses most likely to warrant SLP services. However, association disparities and weakening association of service provision with increasing impairment severity have concerning clinical implications. Health services research methods can be used to further explore SLP practices in SNFs to support equitable service provision.
Automated Measures of Syntactic Complexity in Natural Speech Production: Older and Younger Adults as a Case Study
Authors: Agmon Galit , Pradhan Sameer , Ash Sharon , Nevler Naomi , Liberman Mark , Grossman Murray , Cho Sunghye
Published: January 2024

Purpose:

Multiple methods have been suggested for quantifying syntactic complexity in speech. We compared eight automated syntactic complexity metrics to determine which best captured verified syntactic differences between old and young adults.

Method:

We used natural speech samples produced in a picture description task by younger (n= 76, ages 18–22 years) and older (n= 36, ages 53–89 years) healthy participants, manually transcribed and segmented into sentences. We manually verified that older participants produced fewer complex structures. We developed a metric of syntactic complexity using automatically extracted syntactic structures as features in a multidimensional metric. We compared our metric to seven other metrics: Yngve score, Frazier score, Frazier–Roark score, developmental level, syntactic frequency, mean dependency distance, and sentence length. We examined the success of each metric in identifying the age group using logistic regression models. We repeated the analysis with automatic transcription and segmentation using an automatic speech recognition (ASR) system.

Results:

Our multidimensional metric was successful in predicting age group (area under the curve [AUC] = 0.87), and it performed better than the other metrics. High AUCs were also achieved by the Yngve score (0.84) and sentence length (0.84). However, in a fully automated pipeline with ASR, the performance of these two metrics dropped (to 0.73 and 0.46, respectively), while the performance of the multidimensional metric remained relatively high (0.81).

Conclusions:

Syntactic complexity in spontaneous speech can be quantified by directly assessing syntactic structures and considering them in a multivariable manner. It can be derived automatically, saving considerable time and effort compared to manually analyzing large-scale corpora, while maintaining high face validity and robustness.

Supplemental Material:

https://doi.org/10.23641/asha.24964179
Narrative Intervention for Preschoolers Who Are Deaf and Hard of Hearing Using Listening and Spoken Language: A Pilot Study
Authors: Carden Kameron C. , McWilliam Robin A. , McLeod Ragan H. , Fedewa Megan P.
Published: January 2024

Purpose:

This pilot study aimed to examine the effects of a caregiver-supported, narrative-based intervention program on the story retelling skills of a group of preschoolers who are deaf and hard of hearing (D/HH) using listening and spoken language (LSL).

Method:

A concurrent multiple baseline design across participants was used to determine the effect of a narrative intervention on the story retelling skills of three preschool-age participants who demonstrated complex language delays. Their primary caregivers also functioned as participants. The 6-week narrative intervention program was implemented using a caregiver coaching model during individual therapy sessions. The dependent variable probes were administered twice per week across phases to assess the preschool participants' story retelling skills, including story grammar, complexity, and completeness. Social validity was also evaluated using a caregiver questionnaire.

Results:

A functional relation was demonstrated between the intervention and story retelling across all three preschool participants with notable increases in the inclusion of story grammar elements and episodic completeness. All three participants maintained scores above baseline levels on dependent variable probes across the 6-week maintenance period. Social validity was strong according to the results of a caregiver questionnaire completed at the conclusion of the intervention.

Conclusion:

These findings offer preliminary support for the use of a caregiver-supported, narrative-based intervention program to improve storytelling and retelling skills in preschoolers who are D/HH using LSL.
Middle-Level Managers: Untapped Champions of Evidence-Based Practice?
Authors: Grandbois Kate , Penrod Sara , McGrath Shana , Douglas Natalie F.
Published: January 2024

Purpose:

The purpose of this article is to contend that middle-level managers (MMs) are an untapped resource in speech-language pathology to champion the implementation of evidence-based practices in routine clinical settings. Relevant literature is presented related to middle-level managers and their role in closing the research-to-practice gap. We additionally describe empirical examples from related fields and clinical examples from individuals who are conducting this work now in speech-language pathology.

Conclusions:

Although more research is needed, there is growing evidence that MMs have responsibilities beyond traditional supervisory roles. We argue that they may be key personnel to closing the research-to-practice gap by championing the implementation of evidence-based practice and, as such, we recommend further research and exploration of this innovative area.
Extraction of intersecting palm‐vein and palmprint features for cancellable identity verification
Authors: Lee Jaekwon , Oh Beom‐Seok , Toh Kar‐Ann
Published: January 2024

A novel method based on the cross‐modality intersecting features of the palm‐vein and the palmprint is proposed for identity verification. Capitalising on the unique geometrical relationship between the two biometric modalities, the cross‐modality intersecting points provides a stable set of features for identity verification. To facilitate flexibility in template changes, a template transformation is proposed. While maintaining non‐invertibility, the template transformation allows transformation sizes beyond that offered by the conventional means. Extensive experiments using three public palm databases are conducted to verify the effectiveness the proposed system for identity recognition.
The Trend of Geometric Thinking Studies: A Systematic Review
Authors: Naufal Muhammad Ammar , Abdullah Abdul Halim , Zainal Zaid , Ihsan Hisyam , Zaki Ahmad , Alshaye Ibrahim Abdullah
Published: January 2024

This study focuses on reviewing information from several articles published in educational and social sciences journals worldwide to document the trend of geometric thinking studies in the Indonesian context. The current study shows that the number of publications on geometric thinking has increased in the last four years. The studies conducted in Indonesia and for Indonesian students used a systematic review guided by PRISMA to examine a hundred articles indexed by Scopus, Google Scholar, and Science and Technology Index (SINTA) between 2011 and 2021. Van Hiele’s Geometric Thinking Test, developed by Usiskin, is extensively used when examining geometric thinking levels in the intervention. In addition, descriptive analysis and a t-test are also employed. The result shows that the most common type of geometric thinking experimental research is quasi-experimental design, with the qualitative approach found to be the most used. Therefore, educators should increase the quantity of qualitative and quantitative studies from various nations about geometric thinking. Furthermore, it is also essential to examine the correlation between student performance in geometry and the teacher’s level of geometric thinking. Finally, combining the van Hiele Geometry test with interviews is strongly advised to provide comprehensive and in-depth data for examining geometric thinking.
New chaos function of composition function Gauss map and dyadic transformation map for digital image encryption
Authors: Mudrika Mudrika , Mt Suryadi , Madenda Sarifuddin
Published: January 2024

Encryption algorithms mostly use key-streams generated from random number generators. Several recent studies have shown that the random number generator used is a chaos function. In this paper, a new chaos function will be developed which can be used as a chaotic random number generator. The development is carried out by forming a new chaos function using the function composition method. The function that is composed is the Gauss Map function against the Dyadic Transformation Map. The results of the new chaos function are chaotic, this is based on the results of the analysis obtained from the results of the bifurcation diagram, the Lyapunov Exponent and the National Institute of Standard Technologies Test (NIST) standard randomness test. The results of the bifurcation diagram show that the density is for the value ofα∈ [−30,0] and has periodic properties to choose the values ofβ∈ [−1.02, −0.75],β∈ [−0.60, −0.30],β∈ [0.10, 0.25] andβ∈ [0.55, 0.75]. A positive value of Lyapunov Exponential diagram will be employed alpha equal to negative value (α< 0). The results of the NIST standard randomness test with valuesx0= 0.9,α= −15 andβ= 0.7 resulted in 100 % passing the test (16 tests).
Space-time permutation statistics application to detect cloud-to-ground lightning prone area (Case study: Pasuruan, Indonesia)
Authors: Karisma Ria Dhea Layla Nur , Hamidah Rohmatul , Mulyanto Angga Dwi , Rozi Fachrur , Harini Sri
Published: January 2024

Lightning is a natural phenomenon caused by the release of positive and negative charges occur in cumulonimbus (CB) clouds. CG lightning is a lightning that strikes from the clouds to the ground. This lightning is dangerous for human activities which can cause burns, blindness, and even temporary deafness. This research will determine the areas prone to CG lightning strikes and lightning characteristics in the city of Pasuruan. Space-time permutation scan statistics is a method used to detect prone areas by considering spatial and temporal aspects. This method merely requires case data, such as location and time without using population data. The detected prone areas will be tested for significance using Monte Carlo. It is used to determine the distribution of the sample. In this study, the Monte Carlo test for scanning window is 0.048 (p-value < 0.05), Sekargadung. Thus, making Sekargadung a hotspot for lightning-prone areas. Furthermore, the value is taken based on the highest ratio test (LRT), 11.46, which is the most likely cluster. Based on space-time permutation statistics Sekargadung is the main hotspot prone area in this case study. It has 226 strikes with the intensity of their occurrence with characteristics area dominant paddy field.
Research on the analytical model of rolling force for TiAl alloy pack rolling
Authors: Wang Zhanrui , Tang Guangyao , Lei Zhenyao , Wang Haijun , Xu Zhiqiang , Yu Hui
Published: January 2024

Pack rolling is a hot rolling process for metals with poor plastic forming. The rolling force model is an important model for pack rolling process. Based on the E. Orowan differential equation and the characteristics of pack rolling process, the analytical model of rolling force for pack rolling process was established. Based on the established rolling force model, the influence of roll diameter, reduction rate, metal layer thickness ratio and shear yield stress ratio on the distribution of rolling stress, neutral angle and connection angle was studied. The results indicate that as the increase of reduction rate and shear yield stress ratio, and the reduction of metal layer thickness ratio, the middle layer metal is more prone to plastic deformation. The basic assumptions of the analytical model were verified through a three-dimensional finite element model. The outer layer metal and the middle layer metal were selected as 304 stainless steel and Ti-Al-2Cr-2Nb alloy for pack rolling experiments, respectively. The error between the calculated results of the analytical model and the experimental results is within 15%. The analytical model of rolling force can accurately predict the rolling force and provide theoretical guidance for the formulation of the pack rolling process.
La sélection des étudiants à l’entrée des études de santé : les enjeux de l’égalité des chances
Authors: Nadjafizadeh Marjan
Published: January 2024

Contexte et problématique : Dans tous les pays, le nombre des candidats aux études supérieures conduisant à l’exercice de professions de santé dépasse largement le nombre des places disponibles. Dès lors, se pose inéluctablement le problème du choix des méthodes, des procédés et des épreuves à mettre en œuvre et, corollairement, des critères à prendre en compte pour la sélection des étudiants. Exégèse : L’auteure examine les différentes dimensions de la notion de justice et la manière de la concevoir dans l’enseignement supérieur, lorsqu’une sélection doit être opérée parmi les étudiants, en lien avec les enjeux d’une égalité des chances.
Automated Density Measurement of Weft Knitted Fabrics Using Backlight Imaging
Authors: ZHANG Jing , LIU Shuhua , XIN Binjie , YUAN Zhijie , XU Yingqi
Published: January 2024

This paper proposes a new density measurement algorithm to address the issues of poor applicability and inaccurate results associated with the automatic density measurement algorithm for weft-knitted fabrics. The algorithm involves collecting the transmitted light image of the knitted fabric, calculating the tilt angle using the skewing correction algorithm, and rotating the image to correct the weft skew present therein. The pre-rotated and post-rotated images are then projected vertically and horizontally in grayscale, and the obtained projection curves are used to represent the distribution of loops in vertical and horizontal rows. This study proposed a wave peak coordinate verification algorithm that calculates the coursewise densities and walewise densities of the knitted fabric. In experiments, the proposed density measurement method is found to exhibit an accuracy above 98% when compared with the manual mode.
Analysis and Improvement of a Privacy-Preserving Authentication Scheme for Telecare Medical Information System Environment
Authors: NIU Shufang , KANG Baoyuan , LI Anqian , HUO Yuyan , ZUO Xinyu
Published: January 2024

Telecare Medical Information System (TMIS) can provide various telemedicine services to patients. However, information is communicated over an open channel. An attacker may intercept, replay, or modify this information. Therefore, many authentication schemes are proposed to provide secure communication for TMIS. Recently, Yu et al proposed a privacy-preserving authentication scheme in the Internet of Medical Things (IoMT)-enabled TMIS environments. They emphasize that their scheme is resistant to various attacks and ensures anonymity. Unfortunately, this paper demonstrates that Yu et al's scheme is vulnerable to impersonation attacks, replay attacks, and tracking attacks and cannot mutually authenticate. To overcome the shortcomings of Yu et al's scheme, we mainly improve the authentication and key agreement process and propose a corresponding improved scheme. We also compare the improved scheme with several existing authentication schemes in terms of security and computational efficiency.
Radiosynthesis of α-[18F]Fluoroamides with [18F]AgF
Authors: Xu Bo , Han Junbin , Gong Kehao , Yin Zhengxu , Song Pengfei
Published: January 2024

A silver-promoted nucleophilic radiofluorination of α-bromoamides has been developed for the radiosynthesis of α-[18F]fluoroamides. The reaction conditions are straightforward and compatible with primary, secondary, and tertiary α-bromoamides. Furthermore, the methodology has been successfully applied to the synthesis of bioactive radiotracers with good radiochemical conversion (RCC) and radiochemical yield (RCY).
Outcomes in Patients with Bilateral Distal Radius Fractures
Authors: Kwan Stephanie A. , McEntee Richard , Sodha Samir , Kwok Moody , Beredjiklian Pedro K. , Tulipan Jacob E.
Published: January 2024

Background Fractures of the distal radius that occur bilaterally are comparatively uncommon, with the incidence of these injuries and patient outcomes following different modes of treatment being unknown.

Purpose This article evaluates the demographics, management, and functional outcomes of patients that sustain bilateral distal radius fractures (DRFs).

Materials and Methods We retrospectively identified 85 patients that sustained bilateral DRF and were treated at a single institution from 2016 to 2019. Thirty-four patients were treated operatively, 41 patients were treated nonoperatively, and 10 patients were treated operatively in one extremity and nonoperatively in the other. Fractures were classified by a single fellowship-trained orthopaedic hand surgeon. Range of motion (ROM) data and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) scores were collected. Differences between the three groups with regards to demographics, mechanism of injury (MOI), and complications were recorded.

Results The pediatric population had significantly higher energy MOIs compared to the adult population. There was no difference between the groups with regard to associated injuries or complications. The pediatric population had significantly more AO type A fractures compared to the adult population, which had a bimodal distribution of AO type A and C fractures. The pediatric population saw significantly more patients undergo nonoperative treatment. Both populations had a higher rate of operative intervention for bilateral DRF than noted in the literature for unilateral. In the adult population there were no significant differences in DASH scores between the operative and nonoperative groups.

Conclusion Bilateral DRFs appear to have a similar bimodal age distribution to unilateral DRF. Younger patients undergo nonoperative management more commonly than operative or mixed management. Postoperative ROM and complications appear to be equivalent across all three groups regardless of age.

Level of Evidence Level IV, Prognostic study.
Treatment Failure and Clinical Stability in Severe Community-Acquired Pneumonia
Authors: Méndez Raúl , González-Jiménez Paula , Mengot Noé , Menéndez Rosario
Published: January 2024

Treatment failure and clinical stability are important outcomes in community-acquired pneumonia (CAP). It is essential to know the causes and risk factors for treatment failure and delay in reaching clinical stability in CAP. The study of both as well as the associated underlying mechanisms and host response are key to improving outcomes in pneumonia.
Early Reconstruction with Locoregional-Free Flaps in Post-COVID-19 Rhino-orbital-cerebral Mucormycosis Craniofacial Deformities: A Single-Center Clinical Experience from India
Authors: Singh Veena K. , Haq Ansarul , Sharma Sarsij , Kumari Anupama
Published: January 2024

Aim of the Study Mucormycosis is a rare invasive and fatal fungal infection and its resurgence in coronavirus disease 2019 (COVID-19) patients has been a matter of grave concern. It is essentially a medical disease, but surgical debridement of necrotic tissues is of paramount importance leading to severe craniofacial deformities. In this case series, we present our experience with the feasibility of early reconstruction after surgical debridement.

Case Series As a Dedicated COVID Center (DCH), the institute received the largest population of COVID-19 mucormycosis patients from the entire eastern region of the country between May 2021 and August 2021. More than 5,000 COVID-19 were admitted out of which 218 patients were diagnosed with mucormycosis. Nine patients, seven males and two females, with a mean age of 39 years with craniofacial mucormycosis underwent debridement and early reconstructions (2–4 weeks from first debridement and start of antifungal therapy) with free and pedicled flaps. All flaps survived and showed no evidence of recurrence. The average time of the early reconstruction after surgical debridement was 1.7 weeks once the course of systemic amphotericin B was received.

Conclusion After aggressive surgical resection and a short course of antifungal therapy, early reconstruction can be done safely based on clinical criteria, as long as there is no evidence of hyphae invasion on wound edges in the intraoperative pathology examination.