bluuebunny/crossref_metadata_2025 huggingface dataset:
A „storytelling” mint vezetési eszköz szerepe a munkahelyi elégedettség szintjének és a munkahely vonzóképességének emelésében = The role of storytelling as a management tool in raising the level of job satisfaction and the attractiveness of the workplace
Authors: Cserháti Ilona , Pirisi Károly , Erdélyi Tea
Published: September 2022

A „storytelling” (történetmesélés) mint vezetési eszköz alkalmazása, a heurisztikus jellegű munkák terjedésével párhuzamosan egyre inkább teret nyer és elfogadottá válik a vezetési gyakorlatban. A szerzők kutatásukban egy konkrét szervezetre vonatkozóan vizsgálják, hogy milyen kapcsolat mutatható ki a „storytelling” típusa és gyakorisága, valamint a vezetés megítélése és a munkahely hosszabb távú vonzóképessége között. Saját kérdőíves felmérés kidolgozásával, egy pilot projekt keretében tesztelték a feltételezett összefüggések meglétét. A szakirodalmi áttekintést követően először leíró eszközökkel értékelik a felmérés eredményeit. Majd klaszterelemzéssel alakítanak ki olyan tipikus válaszadói csoportokat, amelyek karakterisztikusan eltérő nézőpontból alakították ki véleményüket a stroytelling érzékelésével, az elkerülhetetlen válságok kezelésének minőségével, valamint a munkahely általános vonzóképességével kapcsolatban. Az eredmények alátámasztják kutatási hipotézisüket, miszerint a „storytelling” megfelelő alkalmazása növeli a bizalmat a vezetés iránt, javítja annak általános megítélését, így a „storytelling” hatékonyan növelheti a munkahely hosszabb távú vonzóképességét.
A mesterséges intelligencia és a digitalizáció hatása a logisztikai munkakörökre – Veszélyben vannak-e a munkahelyek? = The effect of artificial intelligence and digitalization on logistics positions – are jobs in danger?
Authors: Reisinger Dávid , Reisinger Viktor , Nagy Judit
Published: September 2022

A szerzők tanulmányukban az Ipar 4.0 logisztikai vonatkozásainak, a Logisztika 4.0-nak a szállítmányozásra gyakorolt hatásait vizsgálják, munkaerőpiaci nézőpontból. A fuvarszervezés és szállítmányozás gyökeres átalakulás alatt áll, a fuvarszervezői, valamint szállítmányozói feladatkörökre jelentős fenyegetést jelenthet a jövőben a mesterséges intelligencia, a gépi tanulás és ez által a feladatok részbeni vagy teljes automatizációja. A szerzők célja azt megvizsgálni, hogy a különféle, szállítmányozásban végzett szellemi munkakörök mennyire vannak kitéve a gépesítés veszélyének. A tanulmányban a Nemzeti Foglalkoztatási Szolgálat FEOR-jegyzéke szerinti foglalkozásleírásokon szövegelemzési szoftverrel elemzést végrehajtva azt az eredményt kapták, hogy a szállítmányozás szellemi feladatait nem fenyegeti az automatizálás veszélye, és a többi emberi kreativitást, rugalmasságot igénylő szakma esetén is csak részbeni automatizáció lehetséges. Regresszióelemzéssel ugyanakkor azt is kimutatták, hogy a gépesítés nagyobb mértékben fenyegeti az alacsony iskolázottságot igénylő és kereseti lehetőséggel bíró munkákat, és a tipikusan férfiak által végzett munkakörök is gyakrabban esnek ebbe a kategóriába.
Hazai kis- és középvállalkozások weboldalainak vizsgálata egy újszerű értékelési rendszer használatával = Analysis of Hungarian SMEs’ websites using a novel evaluation system
Authors: Harsányi Dávid , Totth Gedeon , Szabó Zoltán , Brávácz Ibolya
Published: September 2022

A tanulmány célja annak áttekintése volt, hogy mi jellemző a KKV-k weboldalaira mind tartalmi, mind formai szempontból. A kutatásban 252 cég vizsgálatára került sor, amelyből 146 (58%) rendelkezett honlappal. A megfigyelés és elemzés után megállapítható, hogy a cégek online jelenléte még fejlesztendő, hiszen egy százpontos vizsgálati rendszerben átlagosan csupán 64 pontot értek el. Pozitívum ugyanakkor, hogy a legnagyobb klaszterbe tartozó vállalkozások átlag feletti eredményt értek el. Az értékelési rendszer megfelelő módszer lehet tehát a honlapok elemzésére, amely az átlagpontszám mellett információval szolgál például a weboldal tartalmi, felhasználói élmény, design vagy technológiai vonatkozásaira is. Így javasolt a módszer kiterjesztése, minden vállalkozás számára elérhetővé tétele.
contato entre derrames vulcânicos como condicionante da ocorrência e da produtividade de aquíferos fraturados
Authors: Sanferari Amanda , Reginato Pedro Antonio Roehe , Quillfeldt Sofia Dalmaz
Published: September 2022

Sistema Aquífero Serra Geral, fraturado e de potencial hídrico intensamente variado, representa o principal reservatório subterrâneo do nordeste do estado do Rio Grande do Sul e é controlado principalmente pelo sistema estrutural das rochas, através da ocorrência de fraturas e zonas de fraturas. Com isso, esse trabalho teve como objetivo avaliar o contato entre derrames vulcânicos como possível condicionante de aquíferos fraturados e sua influência na produtividade de poços tubulares. A pesquisa decorre de um levantamento de dados iniciais, obtidos a partir das informações cedidas pela CORSAN, SIAGAS e dados coletados em campo. Com essas informações, e através de descrições, análises estatísticas e gráficos, foi caracterizada a geologia e hidrogeologia do polígono de estudo. Os resultados permitiram descrever a Formação Gramado como predominante na região, composta por rochas basálticas, com estruturas de contato que não exibe erosão acentuada, mantendo o topo preservado. A Formação Palmas/Caxias diferencia-se por ser composta de rochas ácidas, com contatos de superfície irregular causados por uma estrutura erosiva e localizados em altitudes superiores, geralmente acima dos 539 m. A avaliação da produtividade foi realizada com base na análise dos parâmetros capacidade específica e vazão. O contato entre as formações é marcado pela sobreposição das rochas ácidas através de uma estrutura erosiva e bem definida, preferencialmente localizada entre 500 e 550 m. A avaliação hidrogeológica identificou que poços com entradas de água em altitudes menores que 550 m, possivelmente cruzando a zona de contato entre estas formações, apresentaram maior vazão média que poços associados exclusivamente às rochas da Formação Palmas/Caxias, localizados acima dos 550 m. Quanto a produtividade, os parâmetros indicam classes mais produtivas quando as entradas de água estão localizadas entre 550 e 650m de altitude. Da mesma forma, entradas de água em poços de alta vazão (maiores que 25 m³/h) ocorrem entre 600 e 650 m, e poços que não alcançam zonas de contato entre derrames possuem vazões inferiores ou são improdutivos. Por fim, a avaliação das áreas mais produtivas, através da análise de seções geológicas, indicou que as estruturas de contato estão associadas a entradas de água nos poços, tendo influência na circulação da água e produtividade dos poços.
Considerações sobre a abordagem comunicativa no ensino de língua
Authors: Venturi Maria Alice
Published: September 2022

Este artigo procura enfatizar a comunicação como um conjunto de competências que o estudante adquire progressivamente durante sua formação. Mostra também que o mais importante não é saber sobre o sistema lingÃ¼ístico, mas o que se pode fazer com a linguagem do mundo real. Nessa perspectiva, parte-se da interação como fator primordial para que a aprendizagem aconteça, partindo-se também da consideração de que o aluno é visto como ser social, representante de um ambiente socialmente específico, e que, por sua vez, vai se firmando como verdadeiro sujeito da linguagem.
Recientes investigaciones en la síntesis sustentable de pirazolinas
Authors: Trilleras Jorge , De-La-Ossa-Alían José-José , Pérez-Gamboa Alfredo
Published: September 2022

En química medicinal, se dirigen continuamente extensos esfuerzos en investigación al descubrimiento de nuevos heterociclos con efectos farmacológicos apropiados. Específicamente, el papel de los derivados del pirazol en la química médica es vital debido a su amplia gama de actividades biológicas. Por esta notable observación, se desarrolla esta revisión con enfoque sobre los avances de procedimientos sintéticos eco-amigables en términos de rendimiento, tiempo de reacción corto y condiciones limpias en la obtención de 2-pirazolinas, a partir de un análisis bibliográfico de investigación que toma como referencia los años 2019 a 2021 con respecto a la obtención de estos sistemas en condiciones simplificadas y energéticamente sustentables.
Elementos centrales de experiencias educativas con enfoque STEM
Authors: Ramos-Lizcano Corina , Ángel-Uribe Isabel-Cristina , López-Molina Giovanni , Cano-Ruiz Yuly-Marcela
Published: September 2022

Este artículo presenta una revisión bibliográfica en bases de datos multidisciplinarias para identificar elementos centrales en el desarrollo de experiencias educativas STEM (Science, Technology, Engineering, and Mathematics) desde diversas acepciones como STEM+A o STEAM, para su integración con las artes; STEM+H, por las humanidades; o STEM + Agriculture; entre otros. Este enfoque ha incrementado su presencia en diversos niveles educativos, en parte por la promoción realizada a través de organismos multilaterales como la OCDE y el BID, y por la definición de políticas públicas, en especial en Norteamérica. Se analizaron 67 artículos de investigación, de los cuales se seleccionaron 53 como muestra porque dan cuenta de experiencias STEM desarrolladas en 19 países de cuatro continentes. La mayoría (54.72 %) relaciona experiencias de Norteamérica, especialmente de Estados Unidos, que aporta un 47.17 % del total de las fuentes del estudio. La revisión identifica las siguientes tendencias: los propósitos de aprendizaje, enfocados en el desarrollo de competencias; la colaboración entre grupos y la generación de buenas prácticas para el aprendizaje a lo largo de la vida; el uso de estrategias de aprendizaje activo; el rol de las TIC, que se identifican como articuladoras del desde su rol didáctico; y los factores de éxito del enfoque, en el que el rol del docente que prioriza el aprendizaje es preponderante. De estas tendencias se concluye que el papel del docente en la ejecución de experiencias de aprendizaje con enfoque STEM es fundamental, dadas las implicaciones pedagógicas, didácticas y humanas que supone desarrollarlo.
Propuesta de un conjunto de recomendaciones de accesibilidad para mejorar el posicionamiento de portales web empresariales
Authors: Chanchí-Golondrino Gabriel-Elias , Ospina-Alarcón Manuel-Alejandro , Rico-Rodríguez Fabián
Published: September 2022

Uno de los factores clave que contribuye con la mejora del posicionamiento de los portales web empresariales es la accesibilidad, teniendo en cuenta la gran cantidad de usuarios y el volumen de contenidos disponibles en la Web. La accesibilidad posibilita que los motores de búsqueda den prioridad a aquellos portales que han incorporado dichas características. El objetivo de este artículo es proponer un conjunto de recomendaciones de accesibilidad para mejorar el posicionamiento de portales web empresariales, las cuales fueron determinadas a partir de pautas y niveles de conformidad de la norma de accesibilidad colombiana NTC 5854. Para el desarrollo metodológico de esta investigación, se usaron las cuatro fases del patrón iterativo de investigación propuesto por Pratt: observar, identificar, desarrollar y probar. Estas permitieron definir las recomendaciones y verificar su pertinencia en una inspecciones de accesibilidad. Como resultado principal se obtuvo un conjunto de recomendaciones para el diseño accesible de portales web, enfocadas en mejorar el posicionamiento de estos sitios y agrupadas de acuerdo con los cuatro principios de la norma NTC 5854. Asimismo, se desarrolló una herramienta automatizada que permite la conducción de inspecciones de accesibilidad en portales web haciendo uso de las recomendaciones definidas. A modo de conclusión, la inspección desarrollada sobre el portal web Janus con la herramienta construida permitió verificar la pertinencia de las recomendaciones, de cara a posibilitar que un mayor número de usuarios puedan acceder, percibir, operar y comprender el contenido de la Web.
Políticas públicas e estudos organizacionais: Uma articulação teórica para a análise das formas de organização de programas de pós-graduação na Universidade Federal de Pelotas (Brasil)
Authors: Duquia Andressa Andrade , Franz Alice Hübner , Barcelos Márcio , Rodrigues Marcio Silva
Published: September 2022

Este artigo realiza uma articulação entre abordagens da área de Análise de Políticas Públicas e do campo dos Estudos Organizacionais para examinar os desdobramentos das políticas públicas na área de ensino superior, na gestão e governança de programas de pós-graduação no Brasil. Foram utilizados os conceitos de crença política (policy belief) e narrativa política (policy narrative), articulados à perspectiva da empresarização e disseminação do discurso da empresa, como quadro teórico para a análise das formas de organização dos programas de pós-graduação, a partir da realização de um estudo de caso junto à Universidade Federal de Pelotas (UFPel). Mediante entrevistas realizadas com gestores da universidade e com pesquisadores que ocuparam cargos de coordenação em programas de pós-graduação foi possível traçar um panorama das formas de governança presentes nesses programas. As evidências apontam para a predominância de uma lógica de governança empresarial na qual os atores passam a trabalhar a partir da definição de metas e retorno financeiro como indicadores de eficiência.
Tinjauan Yuridis Karakteristik Penggunaan Hak Pakai dalam Kepemilikan Apartemen oleh Warga Negara Asing di Indonesia
Authors: Mahadewi Kadek Julia
Published: September 2022

Dalam susunan hukum pertanahan nasional, hubungan hukum antara orang, baik warga Negara Indonesia (WNI) maupun warga negara asing (WNA), serta perbuatan hukumnya terkait dengan tanah telah ditentukan   dalam Undang-Undang No 5 Tahun 1960 tentang Peraturan Dasar Pokok – Pokok Agraria (UUPA). Salah satu prinsip yang dipergunakan oleh UUPA adalah prinsip nasionalitas. Hanya WNI yang dapat mempunyai hubungan sepenuhnya dengan tanah sebagai bagian dari bumi dalam frasa yang termuat dalam pasal 33 ayat 3 UUD NRI 1945. Hubungan yang dimaksud adalah dalam wujud dari  hak milik. Sedangkan bagi WNA dan badan hukum asing yang hanya mempunyai perwakilan di Indonesia dapat diberikan hak pakai.Adapun  rumusan  masalah  yang diangkat dalam  jurnal  ini pertama, Bagaimanakah karakteristik hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia? Kedua, Bagaimanakah konsistensi pengaturan hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia? Adapun  kesimpulan  yang  diperoleh pertama, karakteristik hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia adalah suatu hak yang meliputi hak atas tanah bangunan dan tanah pertanian dan  kedua Konsistensi pengaturan hak pakai dalam konsep kepemilikan apartemen oleh warga negara asing di Indonesia adalah pengaturan hak-hak atas tanah bagi orang asing dalam peraturan perundang-undangan antara lain dapat dilihat dalam Pasal 42, 45 dan 55 UUPA.
Tantangan Pelaksanaan Kegiatan Pendaftaran Tanah Sistematis Lengkap dalam Rangka Mewujudkan Pemberian Kepastian Hukum
Authors: Ardani Mira Novana
Published: September 2022

Perwujudan pendaftaran tanah di seluruh wilayah Indonesia telah didukung dengan dikeluarkannya aturan-aturan yang mengatur mengenai pendaftaran tanah, dan dalam rangka percepatan pendaftarannya dilakukan secara sistematis, namun tetap dimungkinkan adanya hambatan, kendala yang ini dapat merupakan suatu tantangan tersendiri untuk mewujudkan amanah yang terdapat dalam Pasal 19 ayat (1) UUPA. Permasalahan yang ada yakni tantangan yang ada dalam pelaksanaan kegiatan pendaftaran tanah sistematis lengkap dalam rangka mewujudkan pemberian kepastian hukum. Metode yang digunakan menggunakan metode yuridis empiris. Tantangan yang ada dalam pelaksanaan kegiatan pendaftaran tanah sistematis lengkap dalam rangka mewujudkan pemberian kepastian hukum berupa kendala dan permasalahan yang dihadapi dalam pelaksanaan kegiatan PTSL   rendahnya minat keikutsertaan masyarakat, serta kendala dan permasalahan terkait dengan bidang yuridis, dan bidang fisik dalam pelaksanaan kegiatan PTSL. Terdapat pula solusi untuk mengatasi kendala dan permasalahan yang menjadi tantangan tersebut, sehingga dapat mewujudkan kepastian hukum.
The Duty of Care in Czech Company Law
Authors: Eichlerová Kateřina
Published: September 2022

The duty of care is a core instrument to incentivise directors to act diligently and in the best interest of the company. The article seeks to answer the following questions concerning the duty of care in company law; 1) who is obliged to exercise it, 2) to whom, 3) what is the content of the duty of care, 4) what place does it occupy among other standards of care, 5) what is its nature, and 6) how does the duty of care differ between a director of a company and director of other legal persons of private law.
The Business Judgment Rule in the Czech Republic
Authors: Josková Lucie
Published: September 2022

Business Judgment Rule has been part of the Czech written law since 2014. Nevertheless, there are many controversies regarding its formulation as well as interpretation. The objective of this paper is to analyse the purpose of BJR and based on this to suggest pre-requisites which must be fulfilled to apply BJR. At the same time the impact of the introduction of BJR into written law is examined.
The Duty of Care in Company Law in Poland
Authors: Gliniecki Bartłomiej
Published: September 2022

The liability of directors for failure to perform their duties in a lawful manner is based on general rules of civil liability, however with some modifications making it suitable for corporate application. The duty of care is considered as one of the major directives that must be followed by directors while executing their corporate duties. Polish company law provides for similar rules of directors’ liability for violating duty of care in all types of companies. Over the last two decades, many judgements and authors have strived to determine the content of the duty of care and identify rules that could be useful to declare liability in certain cases. Currently, as amendments of applicable regulations are being processed, liability rules for violations of the duty of care in Polish company law shall become more unambiguous and effortless for application.
The Duty of Care in Romanian Company Law
Authors: Veress Emöd
Published: September 2022

An enduring problem in company law is the liability of directors to the company for damage caused by wrongful acts. On the one hand, levers must be created whereby this liability exists, is effective, and plays a preventive role: a director is discouraged from carrying out damaging activities. On the other hand, the business world involves taking risks. It is sometimes regular for companies to suffer losses, not because of a mistake by a director but because of factors external to the director’s conduct. The director should therefore be encouraged to take certain risks. It all comes down to a question of balance between responsibility and risk-taking. How this balance has been created in Romanian law, what dilemmas exist, and how the courts apply the rules: the article proposes to analyse these issues.
Prognostic signature related to the immune environment of oral squamous cell carcinoma
Authors: Hua Yingjie , Sun Xuehui , Luan Kefeng , Wang Changlei
Published: September 2022

Oral squamous cell carcinoma (OSCC) prognosis remains poor. Here we aimed to identify an effective prognostic signature for predicting the survival of patients with OSCC. Gene-expression and clinical data were obtained from the Cancer Genome Atlas database. Immune microenvironment-associated genes were identified using bioinformatics. Subtype and risk-score analyses were performed for these genes. Kaplan–Meier analysis and immune cell infiltration level were explored in different subtypes and risk-score groups. The prognostic ability, independent prognosis, and clinical features of the risk score were assessed. Furthermore, immunotherapy response based on the risk score was explored. Finally, a conjoint analysis of the subtype and risk-score groups was performed to determine the best prognostic combination. We found 11 potential prognostic genes and constructed a risk-score model. The subtype cluster 2 and a high-risk group showed the worst overall survival; differences in survival status might be due to the different immune cell infiltration levels. The risk score showed good performance, independent prognostic value, and valuable clinical application. Higher risk scores showed higher Tumor Immune Dysfunction and Exclusion scores, indicating that patients with a high-risk score were less likely to benefit from immunotherapy. Finally, conjoint analysis for the subgroups and risk groups showed the best predictive ability.
Lower trapezius muscle function in people with and without shoulder and neck pain: a systematic review
Authors: Wang Daniel M. , Li Crystal , Hatchard Nicole , Chang Chien George C. , Alm John
Published: September 2022

Context

Shoulder and neck pain are leading causes of disability worldwide. Rotator cuff pathology has strong associations with such pain and is extensively targeted by healthcare practitioners. A dysfunctional lower trapezius muscle has also been shown to contribute to neck and shoulder pain, yet it is often overlooked.

Objectives

This systematic review analyzes those with a history of, or who are currently managing, shoulder or neck pain to indicate differences in measures of lower trapezius function when compared to subjects without that pain.

Methods

Studies with no age restrictions were included in the study. Studies could determine lower trapezius muscle function with any quantifiable measurement tool or clinical assessment. If the study included a control group (no pain) and a comparator group (pain), and if lower trapezius muscle function was assessed in both, the study was typically included. The significance of the lower trapezius muscle function change was summarized in these pain patients. From a final total of 18 studies identified, level of muscle activity, muscle activation, time to onset, muscle strength, and muscle thickness were reported.

Results

The 18 included articles involved 485 participants with shoulder and/or neck pain and 455 without. Half of the shoulder pain studies (6/12), and all of the neck pain studies (6/6), demonstrated that the lower trapezius had a noticeable impact. The lower trapezius muscle in participants with shoulder and neck pain tended to show decreased muscle strength, and decreased time to onset/latency.

Conclusions

The findings from this systematic review should be taken into consideration when assessing and treating patients with shoulder and neck pain. Future studies that define the type and duration of shoulder and neck pain, as well as prospectively assessing lower trapezius muscle function in those with and without that pain, are needed.
Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha
Authors: Sasidharan Pillai Sabitha , Quintos Jose Bernardo
Published: September 2022

Objectives

Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function. We report a 6-year-old girl with iodine deficiency goiter with thyroid function studies mimicking thyroid hormone resistance alpha. Thyroid hormones mediate its effects through thyroid hormone receptors alpha and beta. Biochemical picture of low/low-normal T4 and high/high-normal T3 levels, variably reduced reverse T3 and normal TSH is characteristic of thyroid hormone resistance alpha.

Case presentation

A 6-year-old girl, born out of non-consanguineous marriage presented with goiter of 1.5 years duration. She was without symptoms of thyroid dysfunction. The patient was evaluated at one year of age for macrocephaly with cranial ultrasound which was normal. She had normal growth and development. Patient was vegan and was not on any medications or supplements. Laboratory work up showed TSH 5.03 uIU/mL (0.34–5.5), FT4 0.3 ng/dL (0.58–1.2), FT3 5.3 pg/mL (2.5–3.9), total T3 258 ng/dL (94–241), reverse T3 <5.0 ng/dL (8.3–22.9) and negative thyroglobulin antibody and thyroid peroxidase antibody. Thyroglobulin level was 1,098.8 ng/mL (<13 ug/L), and urine iodine 15.8 ug/L (<100 ug/L) confirming a diagnosis of iodine deficiency goiter. Patient was started on iodine supplements, 150 ug daily and repeat work up 3 months later were TSH: 2.717 uIU/mL, T3, total 182 ng/dL, T4, total 9.3 ug/dL, FT 4 2.1 ng/dL.

Conclusions

Iodine deficiency goiter may present with low FT 4, elevated T3 and normal TSH mimicking thyroid hormone resistance alpha and should be considered in children on restrictive diet.
Crystal structure of 2-chloro-6-formylphenolato-κ2O,O′-(6,6′-(((2,2-dimethylpropane-1,3-diyl)bis(azaneylylidene))bis(methaneylylidene))bis(2-chlorophenolato)κ4
N,N,O,O′)cobalt(III), C26H22Cl3CoN2O4
Authors: Lan Qiaoling , Huang Meifen , Xu Jiajun , Wu Qiong
Published: September 2022

C26H22Cl3CoN2O4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 11.1835(5) Å, b = 11.6782(5) Å, c = 11.9295(5) Å, α = 83.900(3)°, β = 66.911(4)°, γ = 64.232(4)°, V = 1286.83(11) Å3, Z = 2, R

gt
(F) = 0375, wR

ref
(F
2) = 0.0899, T = 213.0 K.
Characteristics of potassium hydroxide lignin from corn stalk and dhaincha
Authors: Nayeem Jannatun , Tian Chao , Rahman M. Mostafizur , Popy Razia Sultana , Ferdous Taslima , Jahan M. Sarwar
Published: September 2022

Non-wood pulping faces environmental and processing problems due to lack of suitable technology. To overcome the challenges, potassium hydroxide pulping was suggested, which can also be integrated with biorefinery. To make a viable biorefinery, all dissolved components need to be utilized. Therefore, in this paper, the dissolved lignin from the potassium hydroxide pulping of corn stalks and dhaincha was isolated and characterized by UV, FTIR, 1H-NMR, 31P-NMR and 2D-NMR spectroscopy and molecular weight and compared with the corresponding dioxane lignins. 1H-NMR and 2D-NMR indicated that potassium hydroxide pulping cleaved β-O-4 aryl ether linkages, and consequently increased phenolic hydroxyl group and reduced molecular weight. It was found that phenolation is an effective method to improve the reactivity and reduce molecular weight, and thus the lignin from the potassium hydroxide liquor was further phenolated. The penolated lignin showed strong NIR bands at 5970 and 6896 cm−1 for aromatic C-H and phenolic O-H group.
Fact-checking initiatives in Portuguese language countries: checking methods and financing strategies
Authors: Durr Missau Lucas , Storch Laura Strelow
Published: September 2022

Purpose

Fact-checking has been changing in recent years from an initial stage in which fact-checkers were more concerned with political discourse to a stage in which combating misinformation becomes the primary purpose. This work examines more closely the standardizing and the customizing aspects of active fact-checking outlets in Portuguese-speaking countries, focusing on the verification methods and organizational models in use.

Design/methodology/approach

Based on Content Analysis, we collected manually 318 posts during June 2019 from each fact-checking outlets website and then examined each post according to six general concepts: discourse, sources, context, classification, graphic representation, and financing. There were 15 active fact-checking outlets in Brazil (13) and Portugal (2). No active outlets were found in the African countries.

Findings

Although there is room for inventiveness in fact-checking practices, it is restricted to the classification models adopted and the graphic representation demanded by them. Only two largest Portuguese-speaking countries (Brazil and Portugal) have active fact-checking initiatives during the study period. In Mozambique, we found the outlet named Mozcheck that was inactive with no published content during the research period. From our analysis, we detected a pattern between the type of misinformation and the media to which it is most often linked: false information was circulated mainly in texts, while false contexts were mainly circulated in videos and images led to more manipulated content. In addition, in relation to the sources used to verification of the content, we noticed a large volume of posts relied only on sources came from contacts with press offices – this was especially true for political issues.

Practical implications

The analyzed data indicates that the standardization tendencies are related to the connection of these initiatives with traditional media. While the contrasting aspects of the fact-checking practices are related to the classification models and the graphic representation created by the outlets.

Social implications

It indicates that fact-checking outlets is still tied to traditional media in terms of its organizational and institutional business model. Inventiveness and innovation are restricted to the practice of fact-checking conducted by journalists and other professionals.

Originality/value

This is the first study to compare the practice of fact-checking in Portuguese-speaking countries and, besides looking at aspects of journalistic practice, it also seeks to analyze organizational elements of fact-checking outlets.
Ionizing radiation based advanced oxidation process for reactive orange 122 dye degradation and kinetics studies
Authors: Ali Saddaqat , Muneer Majid , Khan Khosa Muhammad Kaleem , Alfryyan Nada , Iqbal Munawar
Published: September 2022

In the current study, the degradation of reactive orange 122 (RO 122) dye was carried out under UV and gamma irradiation in presence of H2O2. The effect of variables such as UV exposure time, gamma-ray absorbed dose, initial concentration of dye and oxidant dose were investigated. The removal of 64.10, 58.84 and 55.46 (%) was observed for 50, 100 and 150 (mg/L) dye concentrations, respectively using UV radiation time of 150 (min). The degradation was enhanced to 80.39, 69.95 and 67.01 (%) when UV radiation was employed in the presence of H2O2 (0.5 mL/L) for above concentrations respectively. The degradation was further improved to 97, 92.54 and 81.32 (%) using 5 kGy absorbed dose along with H2O2 (0.5 mL/L). The reduction in chemical oxygen demand (COD) was 77, 64 and 57 (%) using UV/H2O2 (0.5 mL/L), while 63, 56 and 53 (%) in case of gamma/H2O2 for aforementioned concentrations. The removal efficiency (G-value), dose constants (k), dose indispensable for 50, 90 and 99 (%) degradation (D
0.5, D
0.90, and D
0.99) after the treatment with gamma radiation were determined. The G-value was noted as 0.46–0.0711 for 50–150 mg/L dye concentration for gamma irradiated samples which improved to 0.57–0.1204 for above mentioned concentrations in presence of H2O2. The FTIR analysis showed that all the peaks were disappeared using gamma/H2O2 at 5 kGy absorbed dose except a minor peak of −CO stretching. The degradation mechanism of dye followed pseudo-first-order kinetics. A significant decrease in peak area was observed by the HPLC analysis after treating the dye samples with gamma/H2O2 (0.5 mL/L) at absorbed dose of 5 kGy which has proven the process efficiency for dye degradation.
Some But Not Too Much: Multiparticipant Therapy and Positive Patient Outcomes in Skilled Nursing Facilities
Authors: Prusynski Rachel A. , Rundell Sean D. , Pradhan Sujata , Mroz Tracy M.
Published: September 2022

Background and Purpose:

Physical and occupational therapy practices in skilled nursing facilities (SNFs) were greatly impacted by the 2019 Medicare Patient-Driven Payment Model (PDPM). Under the PDPM, the practice of multiparticipant therapy—treating more than one patient per therapy provider per session—increased in SNFs, but it is unknown how substituting multiparticipant therapy for individualized therapy may impact patient outcomes. This cross-sectional study establishes baseline relationships between multiparticipant therapy and patient outcomes using pre-PDPM data.

Methods:

We used Minimum Data Set assessments from all short-term Medicare fee-for-service SNF stays in 2018. Using generalized mixed-effects logistic regression adjusted for therapy volume and patient factors, we examined associations between the proportion of minutes of physical and occupational therapy that were received as multiparticipant sessions during the SNF stay and 2 outcomes: community discharge and functional improvement. Multiparticipant therapy minutes as a proportion of total therapy time were categorized as none, low (below the median of 5%), medium (median to <25%), and high (≥25%) to reflect the 25% multiparticipant therapy limit required by the PDPM.

Results and Discussion:

We included 901 544 patients with complete data for functional improvement and 912 996 for the discharge outcome. Compared with patients receiving no multiparticipant therapy, adjusted models found small positive associations between low and medium multiparticipant therapy levels and outcomes. Patients receiving low levels of multiparticipant therapy had 14% higher odds of improving in function (95% CI 1.09-1.19) and 10% higher odds of community discharge (95% CI 1.05-1.15). Patients receiving medium levels of multiparticipant therapy had 18% higher odds of functional improvement (95% CI 1.13-1.24) and 44% higher odds of community discharge (95% CI 1.34-1.55). However, associations disappeared with high levels of multiparticipant therapy.

Conclusions:

Prior to the PDPM, providing up to 25% multiparticipant therapy was an efficient strategy for SNFs that may have also benefitted patients. As positive associations disappeared with high levels (≥25%) of multiparticipant therapy, it may be best to continue delivering the majority of therapy in SNFs as individualized treatment.
Novel Antidiabetic Medications in Polycystic Ovary Syndrome
Authors:   Avalon University School of Medicine, Willemstad, Curacao, Somagutta Manoj Reddy , Jain Molly ,   Saint James School of Medicine, Park Ridge, Illinois, USA, Uday Utkarsha ,   West Bengal University of Health Sciences, Kolkata, India, Pendyala Siva K. ,   Avalon University School of Medicine, Willemstad, Curacao, Mahadevaiah Ashwini ,   Jagadguru Sri Shivarathreeshwara (JSS) University, Mysore, India, Mahmutaj Greta ,   The University of Medicine, Tirana, Albania, Jarapala Nagendrababu ,   Atlantic University School of Medicine, Gross islet, St. Lucia, Gad Mohamed A. ,   Saint George's School of Medicine, St. George's, Grenada, Srinivas Pathan Mayur ,   Avalon University School of Medicine, Willemstad, Curacao, Sasidharan Nayana ,   Academy of Medical Sciences, Pariyaram, Kerala, India, Mustafa Nafisa ,   The National Ribat University Khartoum, Sudan
Published: September 2022

Polycystic ovary syndrome is a very common endocrine disorder prevalent in premenopausal women. Patients with polycystic ovary syndrome present with abnormal menstruation, ovulation disorders, and hyperandrogenemia. They are often accompanied by insulin resistance, metabolic disorders, and other cardiovascular abnormalities. Also, they have comorbidities, such as dyslipidemia, obesity, diabetes type 2, non-alcoholic fatty liver disease, which all influence the treatment plan. Metformin has been defined as a treatment option in patients with polycystic ovary syndrome. However, the clinical responses to metformin are limited. Thus, the need for novel treatments with a broad range of coverage for the complications is warranted. Sodium-glucose co-transporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, incretin analogs are novel drugs approved for treating type-2 diabetes. Because of their recorded benefit with weight loss, improved insulin resistance, and cardiovascular benefits in recent studies, they may help polycystic ovary syndrome women address the polycystic ovary syndrome-related risk of metabolic, reproductive, and psychological consequences. Limited literature is available on the safety and efficacy of these novel antidiabetic drugs in patients with polycystic ovary syndrome. Thus, this review is investigating the role and effectiveness of novel antidiabetic medication as an early therapeutic option in polycystic ovary syndrome.
Sound-Evoked Responses of Distinct Neuron Classes from the Tail of the Striatum
Authors: Nardoci Matthew B. , Lakunina Anna A. , Henderling Devin C. , Pedregon Jewlyssa C. , Mohn Jennifer L. , Jaramillo Santiago
Published: September 2022

Given its inputs from auditory structures and neuromodulatory systems, the posterior tail of the striatum is ideally positioned to influence behavioral responses to acoustic stimuli according to context and previous rewards. Results from previous studies indicate that neurons in this striatal region display selective responses to sounds. However, it is not clear whether different striatal cell classes code for distinct features of sounds or how different striatal output pathways may use acoustic information to guide behavior. Here we compared the sound-evoked responses of posterior striatal neurons that form the striatal direct pathway (and express the dopamine receptor D1) to the responses of neighboring neurons in naive mice. We achieved this via optogenetic photo-identification of D1-expressing neurons during extracellular electrophysiological recordings in awake head-fixed mice of both sexes. We found that the frequency tuning of sound-responsive direct-pathway striatal neurons is comparable with that of their sound-responsive neighbors. Moreover, we found that both populations encode amplitude-modulated sounds in a similar fashion. These results suggest that different classes of neurons in the posterior striatum of naive animals have similar access to acoustic features conveyed by the auditory system even outside the context of an auditory task.
Regulation of Diacylglycerol Content in Olfactory Neurons Determines Forgetting or Retrieval of Olfactory Memory inCaenorhabditis elegans
Authors: Arai Mary , Kurokawa Itsuki , Arakane Hoshinosuke , Kitazono Tomohiro , Ishihara Takeshi
Published: September 2022

Proper management of memories by forgetting and retrieval is essential for animals to adapt their behavior to changing environments. To elucidate the mechanisms underlying forgetting, we use olfactory learning to an attractive odorant, diacetyl, inCaenorhabditis eleganshermaphrodites as a model. In this learning paradigm, the TIR-1/JNK-1 pathway in AWC sensory neurons accelerates forgetting of the olfactory memory, which is stored as a sensory memory trace in AWA sensory neurons. Our genetic screening revealed that increased neuronal diacylglycerol in the olfactory neuronal circuit, by mutations in diacylglycerol kinase-1,egl-30orgoa-1, Gq and Go type G-proteins, suppresses the forgetting defect in the behavior oftir-1mutants, although the calcium imaging analyses of the olfactory neurons revealed that the sensory memory trace to the odorant was maintained. In contrast, the expression of a gain-of-functiongoa-1gene exclusively in AWC neurons caused a forgetting defect in behavior, although their sensory memory trace declined. Furthermore, the behavioral analysis of animals applied with diacylglycerol analog and measurement of diacylglycerol content by fluorescent imaging suggested that diacylglycerol content in AWC is important for the proper forgetting. These findings raise a possibility that diacylglycerol signaling plays a crucial role in determining whether to forget or to recall in olfactory learning.

SIGNIFICANCE STATEMENTForgetting and retrieval are important processes for proper management of memories, although the mechanisms underlying these processes remain largely unclear. We found that, inCaenorhabditis elegans, diacylglycerol signaling works in a forgetting mechanism downstream of TIR-1/JNK-1 pathway. Mutations that change diacylglycerol content in the olfactory neurons affect behavioral forgetting, although they did not alter the sensory memory trace. This suggests that diacylglycerol in specific neurons may determine the occurrence of retrieving, rather than modifying, the memory traces. Consistent with this hypothesis, application of diacylglycerol analog to animals suggests that diacylglycerol content until memory acquisition decides whether to retrieve or to forget the memory.
Susceptibility and characteristics of infections in patients with glucocorticoid excess or insufficiency: the ICARO tool
Authors: Minnetti Marianna , Hasenmajer Valeria , Sbardella Emilia , Angelini Francesco , Simeoli Chiara , Di Paola Nicola , Cozzolino Alessia , Pivonello Claudia , De Alcubierre Dario , Chiloiro Sabrina , Baldelli Roberto , De Marinis Laura , Pivonello Rosario , Pofi Riccardo , Isidori Andrea M
Published: September 2022

Objective

Registry data show that Cushing's syndrome (CS) and adrenal insufficiency (AI) increase mortality rates associated with infectious diseases. Little information is available on susceptibility to milder forms of infections, especially those not requiring hospitalization. This study aimed to investigate infectious diseases in patients with glucocorticoid disorders through the development of a specific tool.

Methods

We developed and administered the InfeCtions in pAtients with endocRinOpathies (ICARO) questionnaire, addressing infectious events over a 12-month observation period, to 1017 outpatients referred to 4 University Hospitals. The ICARO questionnaire showed good test–retest reliability. The odds of infection (OR (95% CI)) were estimated after adjustment for confounders and collated into the ICARO score, reflecting the frequency and duration of infections.

Results

In total, 780 patients met the inclusion criteria: 43 with CS, 32 with adrenal incidentaloma and mild autonomous cortisol secretion (MACS), and 135 with AI, plus 570 controls. Compared to controls, CS was associated with higher odds of urinary tract infections (UTIs) (5.1 (2.3–9.9)), mycoses (4.4 (2.1–8.8)), and flu (2.9 (1.4–5.8)). Patients with adrenal incidentaloma and MACS also showed an increased risk of UTIs (3.7 (1.7–8.0)) and flu (3.2 (1.5–6.9)). Post-dexamethasone cortisol levels correlated with the ICARO score in patients with CS. AI was associated with higher odds of UTIs (2.5 (1.6–3.9)), mycoses (2.3 (1.4–3.8)), and gastrointestinal infections (2.2 (1.5–3.3)), independently of any glucocorticoid replacement dose.

Conclusions

The ICARO tool revealed a high prevalence of self-reported infections in patients with glucocorticoid disorders. ICARO is the first of its kind questionnaire, which could be a valuable tool for monitoring infections in various clinical settings.
Son of sevenless 1 (SOS1), the RasGEF, interacts with ERα and STAT3 during embryo implantation
Authors: Padmanabhan Renjini A , Zyju Damodaranpillai P , Subramaniam Anand G , Nautiyal Jaya , Laloraya Malini
Published: September 2022

Estrogen accounts for several biological processes in the body; embryo implantation and pregnancy being one of the vital events. This manuscript aims to unearth the nuclear role of Son of sevenless1 (SOS1), its interaction with estrogen receptor alpha (ERα), and signal transducer and activator of transcription 3 (STAT3) in the uterine nucleus during embryo implantation. SOS1, a critical cytoplasmic linker between receptor tyrosine kinase and rat sarcoma virus signaling, translocates into the nucleus via its bipartite nuclear localization signal (NLS) during the ‘window of implantation’ in pregnant mice. SOS1 associates with chromatin, interacts with histones, and shows intrinsic histone acetyltransferase (HAT) activity specifically acetylating lysine 16 (K16) residue of histone H4. SOS1 is a coactivator of STAT3 and a co-repressor of ERα. SOS1 creates a partial mesenchymal–epithelial transition by acting as a transcriptional modulator. Finally, our phylogenetic tree reveals that the two bipartite NLS surface in reptiles and the second acetyl coenzymeA (CoA) (RDNGPG) important for HAT activity emerges in mammals. Thus, SOS1 has evolved into a moonlighting protein, the special class of multi-tasking proteins, by virtue of its newly identified nuclear functions in addition to its previously known cytoplasmic function.
Impact of pre-extraction on xylose recovery from two lignocellulosic agro-wastes
Authors: Kasangana Pierre B. , Auclair Nicolas , Daassi Rodrigue , Durand Kalvin , Rodrigue Denis , Stevanovic Tatjana
Published: September 2022

A dilute acid hydrolysis of rice husk (RH), wheat straw (WS), and their extractive-free residues was investigated with the objective of recovering the highest yield of xylose while keeping at minimum its conversion into furfural. The hydrolysis conditions were determined for different concentrations of sulfuric acid and different reaction times at 121 °C. The pre-extraction with ethanol-water (1:1, v/v) was also examined as a parameter. Using response surface methodology, the optimum conditions for xylose production were identified as 1.8% of acid and 41.4 min of hydrolysis time for RH, while those for its counterpart EF-RH (extractives-free rice husks) were 1.0% acid concentration, for 60 min. The same conditions were also predicted for WS and its EF-WS. Under these conditions, the xylose yield was 79.6%, 82.8%, 94.3%, and 88.6% for RH, EF-RH, WS, and EF-RW, respectively. Under these conditions the minimal furfural yields obtained were 1.2% and 1.3% for RH and EF-RH, and 0.8% and 1.5%, for WS and EF-WS, respectively. These results suggested that the pre-extraction step before the acid hydrolysis affected, at least in part, the xylose recovery from RH, but it was not necessary for a better xylose yield of WS for its bioconversion into valuable bioproducts like xylitol.
Editor’s word
Authors: Dunajevas Eugenijus
Published: September 2022

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Мультиелементний аналіз дикорослих макроміцетів
Authors: Гродзинська Ганна Андріївна , Небесний Віталій Борисович , Самчук Анатолій Іванович
Published: September 2022

Мас-спектрометричне дослідження вмісту 27 елементів у плодових тілах дикорослих шапинкових грибів, зібраних у локалітетах лісових екосистем Київської, Житомирської, Чернігівської, Рівненської, Волинської, Івано-Франківської та Закарпатської областей України зі слабо вираженим антропогенним навантаженням, показало, що концентрації елементів варіюють у досить широкому діапазоні. Літературні дані та отримані нами результати свідчать про потенційну значущість макроміцетів як джерела багатьох мінеральних елементів у раціоні людини. Гриби активно акумулюють P, Mg, Cu, Fe, Zn та ін., причому у представників родини Boletacеae, серед яких є найбільш цінні їстівні види (білий гриб, маслюк, підберезовик, польський гриб, синяк, моховики тощо), спостерігається підвищена біоакумуляційна здатність як щодо токсичних мікроелементів (Сd, Pb, Hg, Be), так і щодо важливих есенціальних елементів, що мають фармакологічне значення (Se, Ge, Ag, Au). Для оцінки біодоступності і безпеки акумульованих у плодових тілах мінеральних елементів необхідні додаткові медико-біологічні дослідження. Зазначене явище видоспецифічності накопичення окремих елементів деякими видами макроміцетів дозволяє використовувати їх як біоіндикатори. Зокрема, підстилкові і гумусові сапротрофи з родини Agaricaceae рекомендовані як біондикатори забруднення ґрунтів важкими металами.
(Des)fazendo-nos e (re)fazendo-nos
Authors: Oliveira Luiz Fernando de
Published: September 2022

O presente texto constitui-se como resenha do livro Foucault: pensador transversátil, de Laerthe de Moraes Abreu Junior. A obra reúne ensaios sobre diversos temas e conceitos presentes no pensamento foucaultiano, desde os mais conhecidos, como humanismo, ética, violência, sujeição e poder, até aqueles sobre os quais os estudiosos costumam se debruçar com menor frequência, caso dos escritos do filósofo francês sobre as artes plásticas, o cinema, a literatura e a música. O tratamento dado a esses temas revela como por trás de sua pulverização e da aparente desconexão entre eles há uma obra caracterizada pela versatilidade e transversalidade de um pensador dedicado a compreender como o homem se tornou aquilo que é.