bluuebunny/crossref_metadata_2025 huggingface dataset:
How Can a Histidine Kinase Respond to Mechanical Stress?
Authors: Kenney Linda J.
Published: July 2021

Bacteria respond to physical forces perceived as mechanical stress as part of their comprehensive environmental sensing strategy. Histidine kinases can then funnel diverse environmental stimuli into changes in gene expression through a series of phosphorelay reactions. Because histidine kinases are most often embedded in the inner membrane, they can be sensitive to changes in membrane tension that occurs, for example, in response to osmotic stress, or when deformation of the cell body occurs upon encountering a surface before forming biofilms, or inside the host in response to shear stress in the kidney, intestine, lungs, or blood stream. A summary of our recent work that links the histidine kinase EnvZ to mechanical changes in the inner membrane is provided and placed in a context of other bacterial systems that respond to mechanical stress.
New Insights on Streptococcus dysgalactiae subsp. dysgalactiae Isolates
Authors: Alves-Barroco Cinthia , Caço João , Roma-Rodrigues Catarina , Fernandes Alexandra R. , Bexiga Ricardo , Oliveira Manuela , Chambel Lélia , Tenreiro Rogério , Mato Rosario , Santos-Sanches Ilda
Published: July 2021

Streptococcus dysgalactiae subsp. dysgalactiae (SDSD) has been considered a strict animal pathogen. Nevertheless, the recent reports of human infections suggest a niche expansion for this subspecies, which may be a consequence of the virulence gene acquisition that increases its pathogenicity. Previous studies reported the presence of virulence genes of Streptococcus pyogenes phages among bovine SDSD (collected in 2002–2003); however, the identity of these mobile genetic elements remains to be clarified. Thus, this study aimed to characterize the SDSD isolates collected in 2011–2013 and compare them with SDSD isolates collected in 2002–2003 and pyogenic streptococcus genomes available at the National Center for Biotechnology Information (NCBI) database, including human SDSD and S. dysgalactiae subsp. equisimilis (SDSE) strains to track temporal shifts on bovine SDSD genotypes. The very close genetic relationships between humans SDSD and SDSE were evident from the analysis of housekeeping genes, while bovine SDSD isolates seem more divergent. The results showed that all bovine SDSD harbor Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas IIA system. The widespread presence of this system among bovine SDSD isolates, high conservation of repeat sequences, and the polymorphism observed in spacer can be considered indicators of the system activity. Overall, comparative analysis shows that bovine SDSD isolates carry speK, speC, speL, speM, spd1, and sdn virulence genes of S. pyogenes prophages. Our data suggest that these genes are maintained over time and seem to be exclusively a property of bovine SDSD strains. Although the bovine SDSD genomes characterized in the present study were not sequenced, the data set, including the high homology of superantigens (SAgs) genes between bovine SDSD and S. pyogenes strains, may indicate that events of horizontal genetic transfer occurred before habitat separation. All bovine SDSD isolates were negative for genes of operon encoding streptolysin S, except for sagA gene, while the presence of this operon was detected in all SDSE and human SDSD strains. The data set of this study suggests that the separation between the subspecies “dysgalactiae” and “equisimilis” should be reconsidered. However, a study including the most comprehensive collection of strains from different environments would be required for definitive conclusions regarding the two taxa.
Morphology, Morphogenesis, and Molecular Phylogeny of a New Freshwater Ciliate, Quadristicha subtropica n. sp. (Ciliophora, Hypotrichia)
Authors: Shao Chen , Gao Qi , Warren Alan , Wang Jingyi
Published: July 2021

The morphology and the regulation of cortical pattern associated with the cell size, division, and phylogenetic position of a new hypotrichous ciliate, Quadristicha subtropica n. sp. collected from a freshwater pond in southern China, were investigated. Quadristicha subtropica n. sp. is characterized as follows: size in vivo 60–115 μm × 25–45 μm; 19–21 adoral membranelles; buccal cirrus near anterior end of endoral and paroral; cirrus IV/3 at about level of buccal vertex; right marginal row begins ahead of buccal vertex; 11–16 right and 12–19 left marginal cirri; and dorsal cilia about 5 μm long. The basic morphogenetic process in Q. subtropica n. sp. is consistent with that of the type species, Quadristicha setigera. Phylogenetic analyses based on small subunit ribosomal DNA sequence data reveal that the systematic position of Q. subtropica n. sp. is rather unstable with low support values across the tree and the genus Quadristicha is not monophyletic.
A Blood Exosomal miRNA Signature in Acute Respiratory Distress Syndrome
Authors: Parzibut Gilles , Henket Monique , Moermans Catherine , Struman Ingrid , Louis Edouard , Malaise Michel , Louis Renaud , Misset Benoît , Njock Makon-Sébastien , Guiot Julien
Published: July 2021

Acute respiratory distress syndrome (ARDS) is a diffuse, acute, inflammatory lung disease characterized by a severe respiratory failure. Recognizing and promptly treating ARDS is critical to combat the high mortality associated with the disease. Despite a significant progress in the treatment of ARDS, our ability to identify early patients and predict outcomes remains limited. The development of novel biomarkers is crucial. In this study, we profiled microRNA (miRNA) expression of plasma-derived exosomes in ARDS disease by small RNA sequencing. Sequencing of 8 ARDS patients and 10 healthy subjects (HSs) allowed to identify 12 differentially expressed exosomal miRNAs (adjusted p < 0.05). Pathway analysis of their predicted targets revealed enrichment in several biological processes in agreement with ARDS pathophysiology, such as inflammation, immune cell activation, and fibrosis. By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR-221-3p, miR-24-3p, miR-98-3p, Let-7d-3p, miR-1273a, and miR-193a-5p). These findings highlight exosomal miRNA dysregulation in the plasma of ARDS patients which provide promising diagnostic biomarkers and open new perspectives for the development of therapeutics.
Adaptation of the Compensatory Stepping Response Following Predictable and Unpredictable Perturbation Training
Authors: Hasegawa Naoya , Tanaka Shintaro , Mani Hiroki , Inoue Takahiro , Wang Yun , Watanabe Kazuhiko , Asaka Tadayoshi
Published: July 2021

Background

Effective training of the backward step response could be beneficial to improve postural stability and prevent falls. Unpredicted perturbation-based balance training (PBT), widely known as compensatory-step training, may enhance the fear of falling and the patterns of postural muscle co-contraction. Contrastingly, PBT with predictable direction or both direction and timing would suppress the fear and the co-contraction patterns during training, but the efficacy of predictable PBT for unpredictable perturbations is still unknown.

Objective

To compare the adaptation effects of compensatory-step training with and without predictable perturbations on backward stepping against unpredictable perturbations.

Methods

Thirty-three healthy young adults were randomly assigned to one of the following step training groups: Unpredicted, Predicted, and Self-initiated. In training sessions, participants were perturbed to induce a compensatory step with (Predicted group) or without (Unpredicted group) knowledge of the perturbation’s direction or while knowing both the direction and timing of the perturbation (Self-initiated group). In test sessions (pre- and post-training), participants were instructed to recover their postural stability in response to an unpredicted perturbation. The margin of stability (MOS), center of mass (COM) shift, and step characteristics were measured during a backward step in both test and training sessions.

Results

All three groups showed a significant increase in the step length and velocity in the post-training sessions compared to those in the pre-training sessions. Moreover, in the Unpredicted and Predicted groups, but not in the Self-initiated group, the MOS at step contact was significantly increased following the training session. In addition, the Self-initiated group showed a significant increase in COM shift at 50 ms after slip onset during training compared to the Unpredicted and Predicted groups.

Conclusion

Unpredicted and predicted PBT improve step characteristics during backward stepping against unpredictable perturbations. Moreover, the unpredictable PBT and PBT with direction-predictable perturbations enhance the feedback postural control reflected as the postural stability at step contact.
Interbrain Synchrony of Team Collaborative Decision-Making: An fNIRS Hyperscanning Study
Authors: Zhang Mingming , Jia Huibin , Wang Guanghai
Published: July 2021

In many situations, decision-making behaviors are mostly composed of team patterns (i.e., more than two persons). However, brain-based models that inform how team interactions contribute and impact team collaborative decision-making (TCDM) behavior, is lacking. To examine the neural substrates activated during TCDM in realistic, interpersonal interaction contexts, dyads were asked to model TCDM toward their opponent, in a multi-person prisoner’s dilemma game, while neural activity was measured using functional near infrared spectroscopy. These experiments resulted in two main findings. First, there are different neural substrates between TCDM and ISDM, which were modulated by social environmental cues. i.e., the low incentive reward yielded higher activation within the left inferior frontal gyrus (IFG), in individual separately decision-making (ISDM) stage while the dorsolateral prefrontal cortex (DLPFC) and the middle frontopolar area was activated in TCDM stage. The high incentive reward evoked a higher interbrain synchrony (IBS) value in the right IFG in TCDM stage. Second, males showed higher activation in the DLPFC and the middle frontopolar area during ISDM, while females evoked higher IBS in the right IFG during TCDM. These sex effects suggest that in individual social dilemma situations, males and females may separately depend on non-social and social cognitive ability to make decisions, while in the social interaction situations of TCDM, females may depend on both social and non-social cognitive abilities. This study provide a compelling basis and interesting perspective for future neuroscience work of TCDM behaviors.
The Relative Weight of Temporal Envelope Cues in Different Frequency Regions for Mandarin Disyllabic Word Recognition
Authors: Zheng Zhong , Li Keyi , Guo Yang , Wang Xinrong , Xiao Lili , Liu Chengqi , He Shouhuan , Feng Gang , Feng Yanmei
Published: July 2021

Objectives

Acoustic temporal envelope (E) cues containing speech information are distributed across all frequency spectra. To provide a theoretical basis for the signal coding of hearing devices, we examined the relative weight of E cues in different frequency regions for Mandarin disyllabic word recognition in quiet.

Design

E cues were extracted from 30 continuous frequency bands within the range of 80 to 7,562 Hz using Hilbert decomposition and assigned to five frequency regions from low to high. Disyllabic word recognition of 20 normal-hearing participants were obtained using the E cues available in two, three, or four frequency regions. The relative weights of the five frequency regions were calculated using least-squares approach.

Results

Participants correctly identified 3.13–38.13%, 27.50–83.13%, or 75.00–93.13% of words when presented with two, three, or four frequency regions, respectively. Increasing the number of frequency region combinations improved recognition scores and decreased the magnitude of the differences in scores between combinations. This suggested a synergistic effect among E cues from different frequency regions. The mean weights of E cues of frequency regions 1–5 were 0.31, 0.19, 0.26, 0.22, and 0.02, respectively.

Conclusion

For Mandarin disyllabic words, E cues of frequency regions 1 (80–502 Hz) and 3 (1,022–1,913 Hz) contributed more to word recognition than other regions, while frequency region 5 (3,856–7,562) contributed little.
Regulation of Satiety Quiescence by Neuropeptide Signaling in Caenorhabditis elegans
Authors: Makino Mei , Ulzii Enkhjin , Shirasaki Riku , Kim Jeongho , You Young-Jai
Published: July 2021

Sleep and metabolism are interconnected homeostatic states; the sleep cycle can be entrained by the feeding cycle, and perturbation of the sleep often results in dysregulation in metabolism. However, the neuro-molecular mechanism by which metabolism regulates sleep is not fully understood. We investigated how metabolism and feeding regulate sleep using satiety quiescence behavior as a readout in Caenorhabditis elegans, which shares certain key aspects of postprandial sleep in mammals. From an RNA interference-based screen of two neuropeptide families, RFamide-related peptides (FLPs) and insulin-like peptides (INSs), we identified flp-11, known to regulate other types of sleep-like behaviors in C. elegans, as a gene that plays the most significant role in satiety quiescence. A mutation in flp-11 significantly reduces quiescence, whereas over-expression of the gene enhances it. A genetic analysis shows that FLP-11 acts upstream of the cGMP signaling but downstream of the TGFβ pathway, suggesting that TGFβ released from a pair of head sensory neurons (ASI) activates FLP-11 in an interneuron (RIS). Then, cGMP signaling acting in downstream of RIS neurons induces satiety quiescence. Among the 28 INSs genes screened, ins-1, known to play a significant role in starvation-associated behavior working in AIA is inhibitory to satiety quiescence. Our study suggests that specific combinations of neuropeptides are released, and their signals are integrated in order for an animal to gauge its metabolic state and to control satiety quiescence, a feeding-induced sleep-like state in C. elegans.
Probabilistic Spike Propagation for Efficient Hardware Implementation of Spiking Neural Networks
Authors: Nallathambi Abinand , Sen Sanchari , Raghunathan Anand , Chandrachoodan Nitin
Published: July 2021

Spiking neural networks (SNNs) have gained considerable attention in recent years due to their ability to model temporal event streams, be trained using unsupervised learning rules, and be realized on low-power event-driven hardware. Notwithstanding the intrinsic desirable attributes of SNNs, there is a need to further optimize their computational efficiency to enable their deployment in highly resource-constrained systems. The complexity of evaluating an SNN is strongly correlated to the spiking activity in the network, and can be measured in terms of a fundamental unit of computation,viz. spike propagation along a synapse from a single source neuron to a single target neuron. We proposeprobabilistic spike propagation, an approach to optimize rate-coded SNNs by interpreting synaptic weights as probabilities, and utilizing these probabilities to regulate spike propagation. The approach results in 2.4–3.69× reduction in spikes propagated, leading to reduced time and energy consumption. We propose Probabilistic Spiking Neural Network Application Processor (P-SNNAP), a specialized SNN accelerator with support for probabilistic spike propagation. Our evaluations across a suite of benchmark SNNs demonstrate that probabilistic spike propagation results in 1.39–2× energy reduction with simultaneous speedups of 1.16–1.62× compared to the traditional model of SNN evaluation.
Clinical and Genetic Predictive Models for the Prediction of Pathological Complete Response to Optimize the Effectiveness for Trastuzumab Based Chemotherapy
Authors: Li Lun , Chen Min , Zheng Shuyue , Li Hanlu , Chi Weiru , Xiu Bingqiu , Zhang Qi , Hou Jianjing , Wang Jia , Wu Jiong
Published: July 2021

Background

Trastuzumab shows excellent benefits for HER2+ breast cancer patients, although 20% treated remain unresponsive. We conducted a retrospective cohort study to optimize neoadjuvant chemotherapy and trastuzumab treatment in HER2+ breast cancer patients.

Methods

Six hundred patients were analyzed to identify clinical characteristics of those not achieving a pathological complete response (pCR) to develop a clinical predictive model. Available RNA sequence data was also reviewed to develop a genetic model for pCR.

Results

The pCR rate was 39.8% and pCR was associated with superior disease free survival and overall survival. ER negativity and PR negativity, higher HER2 IHC scores, higher Ki-67, and trastuzumab use were associated with improved pCR. Weekly paclitaxel and carboplatin had the highest pCR rate (46.70%) and the anthracycline+taxanes regimen had the lowest rate (11.11%). Four published GEO datasets were analyzed and a 10-gene model and immune signature for pCR were developed. Non-pCR patients were ER+PR+ and had a lower immune signature and gene model score. Hormone receptor status and immune signatures were independent predictive factors of pCR.

Conclusion

Hormone receptor status and a 10-gene model could predict pCR independently and may be applied for patient selection and drug effectiveness optimization.
Plasma Amino Acids Metabolomics' Important in Glucose Management in Type 2 Diabetes
Authors: Alqudah Abdelrahim , Wedyan Mohammed , Qnais Esam , Jawarneh Hassan , McClements Lana
Published: July 2021

The perturbation in plasma free amino acid metabolome has been observed previously in diabetes mellitus, and is associated with insulin resistance as well as the onset of cardiovascular disease in this population. In this study, we investigated, for the first time, changes in the amino acid profile in a group of people with and without type 2 diabetes (T2D) with normal BMI, from Jordan, who were only managed on metformin. Twenty one amino acids were evaluated in plasma samples from 124 people with T2D and 67 healthy controls, matched for age, gender and BMI, using amino acids analyser. Total amino acids, essential amino acids, non-essential amino acids and semi-essential amino acids were similar in T2D compared to healthy controls. Plasma concentrations of four essential amino acids were increased in the presence of T2D (Leucine, p < 0.01, Lysine, p < 0.001, Phenylalanine, p < 0.01, Tryptophan, p < 0.05). On the other hand, in relation to non-essential amino acids, Alanine and Serine were reduced in T2D (p < 0.01, p < 0.001, respectively), whereas Aspartate and Glutamate were increased in T2D compared to healthy controls (p < 0.001, p < 0.01, respectively). A semi-essential amino acid, Cystine, was also increased in T2D compared to healthy controls (p < 0.01). Citrulline, a metabolic indicator amino acid, demonstrated lower plasma concentration in T2D compared to healthy controls (p < 0.01). These amino acids were also correlated with fasting blood glucose and HbA1c (p < 0.05). Glutamate, glycine and arginine were correlated with the duration of metformin treatment (p < 0.05). No amino acid was correlated with lipid profiles. Disturbances in the metabolism of these amino acids are closely implicated in the pathogenesis of T2D and associated cardiovascular disease. Therefore, these perturbed amino acids could be explored as therapeutic targets to improve T2D management and prevent associated cardiovascular complications.
Quantum Control of Coherent π-Electron Dynamics in Aromatic Ring Molecules
Authors: Mineo Hirobumi , Phan Ngoc-Loan , Fujimura Yuichi
Published: July 2021

Herein we review a theoretical study of unidirectional π-electron rotation in aromatic ring molecules, which originates from two quasi-degenerate electronic excited states created coherently by a linearly polarized ultraviolet/visible laser with a properly designed photon polarization direction. Analytical expressions for coherent π-electron angular momentum, ring current and ring current-induced magnetic field are derived in the quantum chemical molecular orbital (MO) theory. The time evolution of the angular momentum and the ring current are expressed using the density matrix method under Markov approximation or by solving the time-dependent Schrödinger equation. In this review we present the results of the following quantum control scenarios after a fundamental theoretical description of coherent angular momentum, ring current and magnetic field: first, two-dimensional coherent π-electron dynamics in a non-planar (P)-2,2’-biphenol molecule; second, localization of the coherent π-electron ring current to a designated benzene ring in polycyclic aromatic hydrocarbons; third, unidirectional π-electron rotations in low-symmetry aromatic ring molecules based on the dynamic Stark shift of two relevant excited states that form a degenerate state using the non-resonant ultraviolet lasers. The magnetic fields induced by the coherent π-electron ring currents are also estimated, and the position dependence of the magnetic fluxes is demonstrated.
Cyclopentenone Prostaglandins: Biologically Active Lipid Mediators Targeting Inflammation
Authors: Lee Bohae Rachel , Paing May Hnin , Sharma-Walia Neelam
Published: July 2021

Cyclopentenone prostaglandins (cyPGs) are biologically active lipid mediators, including PGA2, PGA1, PGJ2, and its metabolites. cyPGs are essential regulators of inflammation, cell proliferation, apoptosis, angiogenesis, cell migration, and stem cell activity. cyPGs biologically act on multiple cellular targets, including transcription factors and signal transduction pathways. cyPGs regulate the inflammatory response by interfering with NF-κB, AP-1, MAPK, and JAK/STAT signaling pathways via both a group of nuclear receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) dependent and PPAR-γ independent mechanisms. cyPGs promote the resolution of chronic inflammation associated with cancers and pathogen (bacterial, viral, and parasitic) infection. cyPGs exhibit potent effects on viral infections by repressing viral protein synthesis, altering viral protein glycosylation, inhibiting virus transmission, and reducing virus-induced inflammation. We summarize their anti-proliferative, pro-apoptotic, cytoprotective, antioxidant, anti-angiogenic, anti-inflammatory, pro-resolution, and anti-metastatic potential. These properties render them unique therapeutic value, especially in resolving inflammation and could be used in adjunct with other existing therapies. We also discuss other α, β -unsaturated carbonyl lipids and cyPGs like isoprostanes (IsoPs) compounds.
Differential Effects of Focused Attention and Open Monitoring Meditation on Autonomic Cardiac Modulation and Cortisol Secretion
Authors: Ooishi Yuuki , Fujino Masahiro , Inoue Vimala , Nomura Michio , Kitagawa Norimichi
Published: July 2021

Mindfulness-based interventions (MBIs) have been used widely as a useful tool for the alleviation of various stress-related symptoms. However, the effects of MBIs on stress-related physiological activity have not yet been ascertained. MBIs primarily consist of focused-attention (FA) and open-monitoring (OM) meditation. Since differing effects of FA and OM meditation on brain activities and cognitive tasks have been mentioned, we hypothesized that FA and OM meditation have also differing effects on stress-related physiological activity. In this study, we examined the effects of FA and OM meditation on autonomic cardiac modulation and cortisol secretion. Forty-one healthy adults (aged 20–46 years) who were meditation novices experienced 30-min FA and OM meditation tasks by listening to instructions. During resting- and meditation-states, electrocardiogram transducers were attached to participants to measure the R-R interval, which were used to evaluate heart rate (HR) and perform heart rate variability (HRV) analyses. Saliva samples were obtained from participants pre- and post-meditation to measure salivary cortisol levels. Results showed that FA meditation induced a decrease in HR and an increase in the root mean square of successive differences (rMSDD). In contrast, OM meditation induced an increase in the standard deviation of the normal-to-normal interval (SDNN) to rMSSD ratio (SDNN/rMSSD) and a decrease in salivary cortisol levels. These results suggest that FA meditation elevates physiological relaxation, whereas OM meditation elevates physiological arousal and reduces stress.
Heterophylly Quantitative Trait Loci Respond to Salt Stress in the Desert Tree Populus euphratica
Authors: Fu Yaru , Li Feiran , Mu Shuaicheng , Jiang Libo , Ye Meixia , Wu Rongling
Published: July 2021

Heterophylly, or leaf morphological changes along plant shoot axes, is an important indicator of plant eco-adaptation to heterogeneous microenvironments. Despite extensive studies on the genetic control of leaf shape, the genetic architecture of heterophylly remains elusive. To identify genes related to heterophylly and their associations with plant saline tolerance, we conducted a leaf shape mapping experiment using leaves from a natural population of Populus euphratica. We included 106 genotypes grown under salt stress and salt-free (control) conditions using clonal seedling replicates. We developed a shape tracking method to monitor and analyze the leaf shape using principal component (PC) analysis. PC1 explained 42.18% of the shape variation, indicating that shape variation is mainly determined by the leaf length. Using leaf length along shoot axes as a dynamic trait, we implemented a functional mapping-assisted genome-wide association study (GWAS) for heterophylly. We identified 171 and 134 significant quantitative trait loci (QTLs) in control and stressed plants, respectively, which were annotated as candidate genes for stress resistance, auxin, shape, and disease resistance. Functions of the stress resistance genes ABSCISIC ACIS-INSENSITIVE 5-like (ABI5), WRKY72, and MAPK3 were found to be related to many tolerance responses. The detection of AUXIN RESPONSE FACTOR17-LIKE (ARF17) suggests a balance between auxin-regulated leaf growth and stress resistance within the genome, which led to the development of heterophylly via evolution. Differentially expressed genes between control and stressed plants included several factors with similar functions affecting stress-mediated heterophylly, such as the stress-related genes ABC transporter C family member 2 (ABCC2) and ABC transporter F family member (ABCF), and the stomata-regulating and reactive oxygen species (ROS) signaling gene RESPIRATORY BURST OXIDASE HOMOLOG (RBOH). A comparison of the genetic architecture of control and salt-stressed plants revealed a potential link between heterophylly and saline tolerance in P. euphratica, which will provide new avenues for research on saline resistance-related genetic mechanisms.
Analysis of Psychosocial Adjustment in the Family During Confinement: Problems and Habits of Children and Youth and Parental Stress and Resilience
Authors: Andrés-Romero Magdalena P. , Flujas-Contreras Juan M. , Fernández-Torres Mercedes , Gómez-Becerra Inmaculada , Sánchez-López Pilar
Published: July 2021

The COVID-19 health crisis has led to a dramatic change in dynamics and habits of families, which may be a factor involved in the development and maintenance of problems and difficulties in children. The present study is a cross-sectional study that aims to describe and analyze the relationship between the difficulties in psychological adjustment and the change of habits of the infant-juvenile population as perceived by their parents and their stress and resilience during the total confinement of the first wave of the COVID-19 pandemic in Spain, as well as analyzing the course of the changes and the relationships between weeks 3 to 6, that is, the score of different participants in each week of the confinement. The sample is comprised of 883 parents of children and adolescents between 3 and 18 years of age. Children’s psychological adjustment, children’s habits, parental stress, and parental resilience were assessed by parents. The results show that parents perceive a change in the habits and psychological difficulties in their children. At the same time, our results describe parents with a high level of stress and resilience, with differences depending on the children’s ages. The time of confinement accentuates the perception of parents about the psychological difficulties of their children and parental stress, as well as a decrease in resilience. These difficulties are reduced when the parent has resilience competencies. These results show that the resilience of parents mediate the relationship between parental stress and psychological problems of their children. These results shows that COVID-19 lockdown had a considerable effect on families, both on children and parents. Some practical implications based on results are provided.
Impacts of Self-Regulated Strategy Development-Based Revision Instruction on English-as-a-Foreign-Language Students' Self-Efficacy for Text Revision: A Mixed-Methods Study
Authors: Chen Jing , Zhang Lawrence Jun , Wang Xiao , Zhang Tingting
Published: July 2021

This mixed-methods study investigated the impacts of the self-regulated strategy development (SRSD) model on the self-efficacy of students for text revision in English-as-a-foreign-language (EFL) writing at the tertiary level. An SRSD treatment group and a comparison group were involved in this quasi-experimental design research. Both groups completed a self-efficacy scale before and after the instruction, and six SRSD-trained students participated in pre- and post-test interviews. The quantitative analyses did not detect any significant differences between groups, suggesting that the SRSD instruction did not influence the self-efficacy of participants for text revision. The qualitative findings provided insights into the quantitative results. The interview data indicated that the interviewees might have overestimated their revision abilities before instruction and, with the relatively more accurate estimation of their abilities resulting from receiving the SRSD instruction, the over-time comparison of their responses to the self-efficacy scale did not reveal any statistically significant changes. Our findings suggest that students might have recorded evidence of closer calibration between judgments of their revision abilities and their actual performance after SRSD instruction. The implications of the findings were discussed and directions for further studies were provided.
Narcissistic Personality Disorder: Are Psychodynamic Theories and the Alternative DSM-5 Model for Personality Disorders Finally Going to Meet?
Authors: Schalkwijk Frans , Luyten Patrick , Ingenhoven Theo , Dekker Jack
Published: July 2021

Narcissistic Personality Disorder is the new borderline personality disorder of our current era. There have been recent developments on narcissism that are certainly worthwhile examining. Firstly, relational and intersubjective psychoanalysts have been rethinking the underlying concepts of narcissism, focusing on the development of self and relations to others. Secondly, in the DSM-5, the Alternative DSM-5 Model for Personality Disorders (AMPD) was presented for a dimensional evaluation of the severity of personality disorder pathology. The combined dimensional and trait conceptualization of NPD opened the door to new integrated diagnostic perspectives, including both internal and interpersonal functioning. Finally, Pincus and Lukowitsky encourage clinicians to use a hierarchical model of pathological narcissism, as it opens up opportunities for shared points of interest in empirical research from different scholarly perspectives. As for most non-psychodynamic clinicians and researchers the DSM-5 clearly bears dominant weight in their work, we will take the AMPD model for NPD as our point of reference. We will discuss the narcissist's unique pattern of self-impairments in identity and self-direction, and of interpersonal disfunctioning (evaluated by assessing empathy and intimacy). Subsequently, we will examine how contemporary psychodynamic theories and the hierarchical model of Pincus and Lukowitsky additionally inform or contradict the AMPD. For us, one of the big advantages of the AMPD is the use of structured clinical evaluations of disturbances of the self and interpersonal functioning and the dimensional evaluation of severity. As psychodynamically oriented therapists, we are enthusiastic about the opportunities for inclusion of psychodynamic concepts, but we also discuss a number of sticking points.
Some Assembly Required: Player Mental Models of Videogame Avatars
Authors: Banks Jaime , Bowman Nicholas David
Published: July 2021

In playing videogames, players often create avatars as extensions of agency into those spaces, where the player-avatar relationship (PAR) both shapes gameplay and is the product of gameplay experiences. Avatars are generally understood as singular bodies; however, we argue they are functional and phenomenological assemblages—networks of social and technological components that are internalized by players as networks of knowledge about the avatar. Different PARs are based on different internalizations (i.e., mental models) for what an avatar is and why it matters. Toward illuminating nuances in PARs, we examine the content and structure of players’ internalizations of avatars as evidenced by descriptions of those digital bodies. Secondary analysis ofN= 1,201 avatar descriptions parceled them by PAR type (avatars as asocial Objects, psychologically merged extensions of Me, hybrid me/other Symbiotes, and authentically social Other). Aggregated descriptions for each PAR type were subjected to semantic network analysis to identify patterns in salient avatar components, and then qualitatively compared across the four PARs. Results indicate component clusters that are universal to PARs (demographics and body features), common to three of four PARs (time, appearance, clothing, and player agency), and idiosyncratic to specific PARs (significance, character narratives, game dynamics, liminality, and gratifications). Findings signal the importance of theoretically engaging avatars as assemblages both (a) influenced by player-avatar sociality and (b) that contribute (in part and whole) to antecedents, processes, and effects of gameplay.
Psychological Wellbeing, Mindfulness, and Immunity of Teachers in Second or Foreign Language Education: A Theoretical Review
Authors: Li Shengji
Published: July 2021

The emotions and affective factors of teachers play quintessential roles in academic contexts as they influence almost all aspects of their profession. T provide a theoretical review of some psychology constructs of teachers in this area, this study examines the psychological wellbeing, mindfulness, and immunity of teachers as three novel variables. More specifically, this study presents the definitions, dimensions, theories, and frameworks related to this domain drawing on positive psychology, complexity/dynamic systems theory, self-organization process, reflexive self-consciousness theory, integrative awareness theories, and mindfulness framework. These theoretical underpinnings explain the constructs and the way they function in second language education. Then, to provide evidence and justify the findings and propositions, empirical studies on each of the variables are reviewed. Finally, implications, research gaps, and suggestions for future inquiries are offered to interested researchers.
Suicidality Presented to a Child and Adolescent Psychiatry Emergency Service: Increasing Rate and Changing Characteristics
Authors: Kandsperger Stephanie , Jarvers Irina , Schleicher Daniel , Ecker Angelika , Wirth Michael , Brunner Romuald
Published: July 2021

Background: Children and adolescents who present to child and adolescent psychiatric emergency departments show a variety of reasons for their presentations. Suicidality, in particular suicidal thoughts and suicide attempts, as well as non-suicidal self-injury (NSSI) play a large and important role. In this context, inpatient admissions frequently serve as crisis intervention.

Methods: In this study, face-to-face emergency presentations to the emergency department at our Clinic of Child and Adolescent Psychiatry (CAP) were analyzed over the years 2014-2018, the 4th quarter (October-December) of each year. Data from 902 emergency presentations were evaluated, primarily with regard to suicidal thoughts, suicide attempts, and NSSI as reasons for presentation.

Results: Data demonstrated that the number of emergency presentations increased in general and especially for suicidal thoughts and NSSI as reasons for presentation. In addition, suicidal thoughts, suicide attempts, and NSSI as reasons for emergency presentation were more likely to result in crisis-related inpatient admissions. Furthermore, reporting suicide attempts at emergency presentation was associated with longer inpatient stays. Finally, cases with multiple diagnoses increased independent of the general increase in emergency presentations.

Conclusion: The increase of utilization of clinics with CAP outpatient emergency patients and following admissions to the inpatient units for crisis intervention poses a major challenge for the future. It is important to prepare for the assessment and treatment of suicidality, which is of extraordinary importance in the care of emergency patients.
National Health Systems and COVID-19 Death Toll Doubling Time
Authors: Alfaro Miguel , Muñoz-Godoy Diego , Vargas Manuel , Fuertes Guillermo , Duran Claudia , Ternero Rodrigo , Sabattin Jorge , Gutierrez Sebastian , Karstegl Natalia
Published: July 2021

Coronavirus disease 2019 (COVID-19) has placed stress on all National Health Systems (NHSs) worldwide. Recent studies on the disease have evaluated different variables, namely, quarantine models, mitigation efforts, damage to mental health, mortality of the population with chronic diseases, diagnosis, use of masks and social distancing, and mortality based on age. This study focused on the four NHSs recognized by the WHO. These systems are as follows: (1) The Beveridge model, (2) the Bismarck model, (3) the National Health Insurance (NHI) model, and (4) the “Out-of-Pocket” model. The study analyzes the response of the health systems to the pandemic by comparing the time in days required to double the number of disease-related deaths. The statistical analysis was limited to 56 countries representing 70% of the global population. Each country was grouped into the health system defined by the WHO. The study compared the median death toll DT, between health systems using Mood's median test method. The results show high variability of the temporal trends in each group; none of the health systems for the three analyzed periods maintain stable interquartile ranges (IQRs). Nevertheless, the results obtained show similar medians between the study groups. The COVID-19 pandemic saturates health systems regardless of their management structures, and the result measured with the time for doubling death rate variable is similar among the four NHSs.
Perception in Black and White: Effects of Intonational Variables and Filtering Conditions on Sociolinguistic Judgments With Implications for ASR
Authors: Holliday Nicole R.
Published: July 2021

This study tests the effects of intonational contours and filtering conditions on listener judgments of ethnicity to arrive at a more comprehensive understanding on how prosody influences these judgments, with implications for austomatic speech recognition systems as well as speech synthesis. In a perceptual experiment, 40 American English listeners heard phrase-long clips which were controlled for pitch accent type and focus marking. Each clip contained either two H* (high) or two L+H* (low high) pitch accents and a L-L% (falling) boundary tone, and had also previously been labelled for broad or narrow focus. Listeners rated clips in two tasks, one with unmodified stimuli and one with stimuli lowpass filtered at 400 Hz, and were asked to judge whether the speaker was “Black” or “White”. In the filtered condition, tokens with the L+H* pitch accent were more likely to be rated as “Black”, with an interaction such that broad focus enhanced this pattern, supporting earlier findings that listeners may perceive African American Language as having more variation in possible pitch accent meanings. In the unfiltered condition, tokens with the L+H* pitch accent were less likely to be rated as Black, with no effect of focus, likely due to the fact that listeners relied more heavily on available segmental information in this condition. These results enhance our understanding of cues listeners rely on in making social judgments about speakers, especially in ethnic identification and linguistic profiling, by highlighting perceptual differences due to listening environment as well as predicted meaning of specific intonational contours. They also contribute to our understanding of the role of how human listeners interpret meaning within a holistic context, which has implications for the construction of computational systems designed to replicate the properties of natural language. In particular, they have important applicability to speech synthesis and speech recognition programs, which are often limited in their capacities due to the fact that they do not make such holistic sociolinguistic considerations of the meanings of input or output speech.
Aiding Grasp Synthesis for Novel Objects Using Heuristic-Based and Data-Driven Active Vision Methods
Authors: Natarajan Sabhari , Brown Galen , Calli Berk
Published: July 2021

In this work, we present several heuristic-based and data-driven active vision strategies for viewpoint optimization of an arm-mounted depth camera to aid robotic grasping. These strategies aim to efficiently collect data to boost the performance of an underlying grasp synthesis algorithm. We created an open-source benchmarking platform in simulation (https://github.com/galenbr/2021ActiveVision), and provide an extensive study for assessing the performance of the proposed methods as well as comparing them against various baseline strategies. We also provide an experimental study with a real-world two finger parallel jaw gripper setup by utilizing an existing grasp planning benchmark in the literature. With these analyses, we were able to quantitatively demonstrate the versatility of heuristic methods that prioritize certain types of exploration, and qualitatively show their robustness to both novel objects and the transition from simulation to the real world. We identified scenarios in which our methods did not perform well and objectively difficult scenarios, and present a discussion on which avenues for future research show promise.
Let There be Light—A Rare Glimpse Into the Lives of Our gut Bacteria
Authors: Golberg Anna , Geva-Zatorsky Naama
Published: July 2021

Our gut bacteria influence multiple physiological process including the immune response of our body. In this article, we describe a method for labeling anaerobic gut bacteria with a fluorescent marker that reflects light if it is illuminated, just like light reflectors on our bikes. This marker can be identified by a special microscope. Using this marker, we can act as detectives and track the activity of our gut bacteria in their natural environment. This method allowed us to see the interaction of bacteria with various immune system cells and where the bacteria chose to settle along the digestive system.
“‘The Tragedy of the Punch Drunk': Reading Concussion in Australian Sporting Newspapers, 1843–1954”
Authors: Townsend Stephen
Published: July 2021

Australian cultural attitudes toward sports related concussion (SRC) are understudied. Australia has a long history of valorising combat, collision, and contact sports, in which SRC is a common occurrence. It is therefore vital to understand how sociocultural and historical factors shape Australian attitudes toward SRC, in order to more critically evaluate the decisions made by athletes, parents, coaches, and others with regards to risk and brain injury in sport. This paper analyzed historical representations of SRC in Australian sporting newspapers between 1803 and 1954. Using distant reading, this analysis revealed four distinct periods of increased press discourse about “concussion,” which were subject to interrogationviaclose reading. Close reading revealed that concussion was being reported in the Australian sporting press as early as 1859. Further analysis revealed critical and scientifically informed discussions about the delayed effects of concussion in 1901, systemic critiques of sporting organizations' response to concussion in 1906, and evidence of a limited concussion crisis in Australian boxing during the early 1930s. The findings of this research show that concussion was not only being reported in Australian newspapers throughout the late nineteenth and early twentieth centuries but it was subject to critical and informed commentary that has striking similarities with current debates about SRC. Despite this, widespread systematic changes to Australian sport did not occur until recently. This raises important questions about the political and institutional factors that prevented a major concussion crisis from developing in Australia during the early twentieth century, and prompts us to further consider the distinguishing features that facilitated the development of the current crisis.
Expansion of Agriculture in Northern Cold-Climate Regions: A Cross-Sectoral Perspective on Opportunities and Challenges
Authors: Unc Adrian , Altdorff Daniel , Abakumov Evgeny , Adl Sina , Baldursson Snorri , Bechtold Michel , Cattani Douglas J. , Firbank Les G. , Grand Stéphanie , Guðjónsdóttir María , Kallenbach Cynthia , Kedir Amana J. , Li Pengfei , McKenzie David B. , Misra Debasmita , Nagano Hirohiko , Neher Deborah A. , Niemi Jyrki , Oelbermann Maren , Overgård Lehmann Jesper , Parsons David , Quideau Sylvie , Sharkhuu Anarmaa , Smreczak Bożena , Sorvali Jaana , Vallotton Jeremiah D. , Whalen Joann K. , Young Erika H. , Zhang Mingchu , Borchard Nils
Published: July 2021

Agriculture in the boreal and Arctic regions is perceived as marginal, low intensity and inadequate to satisfy the needs of local communities, but another perspective is that northern agriculture has untapped potential to increase the local supply of food and even contribute to the global food system. Policies across northern jurisdictions target the expansion and intensification of agriculture, contextualized for the diverse social settings and market foci in the north. However, the rapid pace of climate change means that traditional methods of adapting cropping systems and developing infrastructure and regulations for this region cannot keep up with climate change impacts. Moreover, the anticipated conversion of northern cold-climate natural lands to agriculture risks a loss of up to 76% of the carbon stored in vegetation and soils, leading to further environmental impacts. The sustainable development of northern agriculture requires local solutions supported by locally relevant policies. There is an obvious need for the rapid development of a transdisciplinary, cross-jurisdictional, long-term knowledge development, and dissemination program to best serve food needs and an agricultural economy in the boreal and Arctic regions while minimizing the risks to global climate, northern ecosystems and communities.