bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and dynamic analysis of integrated architecture for vibration energy harvesting including piezoelectric frame and mechanical amplifier
Authors: Duan Xiangjian , Cao Dongxing , Li Xiaoguang , Shen Yongjun
Published: May 2021

Vibration energy harvesters (VEHs) can transform ambient vibration energy to electricity and have been widely investigated as promising self-powered devices for wireless sensor networks, wearable sensors, and applications of a micro-electro-mechanical system (MEMS). However, the ambient vibration is always too weak to hinder the high energy conversion efficiency. In this paper, the integrated frame composed of piezoelectric beams and mechanical amplifiers is proposed to improve the energy conversion efficiency of a VEH. First, the initial structures of a piezoelectric frame (PF) and an amplification frame (AF) are designed. The dynamic model is then established to analyze the influence of key structural parameters on the mechanical amplification factor. Finite element simulation is conducted to study the energy harvesting performance, where the stiffness characteristics and power output in the cases of series and parallel load resistance are discussed in detail. Furthermore, piezoelectric beams with variable cross-sections are introduced to optimize and improve the energy harvesting efficiency. Advantages of the PF with the AF are illustrated by comparison with conventional piezoelectric cantilever beams. The results show that the proposed integrated VEH has a good mechanical amplification capability and is more suitable for low-frequency vibration conditions.
Heart Rate Variability Reactivity to Food Image Stimuli is Associated with Body Mass Index
Authors: Chang Jung-Chi , Huang Wei-Lieh , Liu Chao-Yu , Tseng Meg Mei-Chih , Yang Cheryl C. H. , Kuo Terry B. J.
Published: May 2021

Appetitive control is driven by the hedonic response to food and affected by several factors. Heart rate variability (HRV) signals have been used to index autonomic activity and arousal levels towards visual stimuli. The current research aimed to examine the influence of body mass index (BMI), disordered eating behaviors, and sex on the HRV reactivity to food in a nonclinical sample. Thirty-eight healthy male and sixty-one healthy female participants completed questionnaires assessing disordered eating symptoms. HRV was recorded when the participants received visual stimuli of high-calorie food, neutral and negative emotional signals. Generalized estimating equation models were used to investigate the associations between HRV, BMI, disordered eating behaviors, and sex across the three stimulus types. Male participants demonstrated a higher ratio of low-frequency power to high-frequency power (LF/HF) than females across all the stimulus types. An increase in LF/HF reactivity to food signals was observed in all the study subjects. The moderation effect of BMI on LF/HF in response to food signals was also observed. Our study suggests that body weight may play a role in the interaction between sympathetic activity and food stimuli; however, how the interaction between sympathetic activity and food stimuli contributes to diet control warrants further investigation.
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
Authors: Wijaya Lukas S. , Rau Carina , Braun Theresa S. , Marangoz Serif , Spegg Vincent , Vlasveld Matthijs , Albrecht Wiebke , Brecklinghaus Tim , Kamp Hennicke , Beltman Joost B. , Hengstler Jan G. , van de Water Bob , Leist Marcel , Schildknecht Stefan
Published: May 2021

Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how intracellular glutathione can be elevated transiently to render cells more resistant toward harmful conditions. The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes. In intact cells, activation of NFT yielded a radical anion, which subsequently initiated nuclear-factor-erythroid 2-related-factor-2 (Nrf2)-dependent induction of glutamate cysteine ligase (GCL). Application of siRNA-based intervention approaches confirmed the involvement of the Nrf2-GCL axis in the observed elevation of intracellular glutathione levels. Quantitative activation of Nrf2 by NFT, and the subsequent rise in glutathione, were similar as observed with the potent experimental Nrf2 activator diethyl maleate. The elevation of glutathione levels, observed even 48 h after withdrawal of NFT, rendered cells resistant to different stressors such as the mitochondrial inhibitor rotenone, the redox cycler paraquat, the proteasome inhibitors MG-132 or bortezomib, or high concentrations of NFT. Repurpose of the antibiotic NFT as activator of Nrf2 could thus be a promising strategy for a transient and targeted activation of the endogenous antioxidant machinery.
Influence of biological origin on the tensile properties of cellulose nanopapers
Authors: Kontturi Katri S. , Lee Koon-Yang , Jones Mitchell P. , Sampson William W. , Bismarck Alexander , Kontturi Eero
Published: May 2021

Cellulose nanopapers provide diverse, strong and lightweight templates prepared entirely from sustainable raw materials, cellulose nanofibers (CNFs). Yet the strength of CNFs has not been fully capitalized in the resulting nanopapers and the relative influence of CNF strength, their bonding, and biological origin to nanopaper strength are unknown. Here, we show that basic principles from paper physics can be applied to CNF nanopapers to illuminate those relationships. Importantly, it appeared that ~ 200 MPa was the theoretical maximum for nanopapers with random fibril orientation. Furthermore, we demonstrate the contrast in tensile strength for nanopapers prepared from bacterial cellulose (BC) and wood-based nanofibrillated cellulose (NFC). Endemic amorphous polysaccharides (hemicelluloses) in NFC act as matrix in NFC nanopapers, strengthening the bonding between CNFs just like it improves the bonding between CNFs in the primary cell wall of plants. The conclusions apply to all composites containing non-woven fiber mats as reinforcement.

Graphic abstract
Computing mixed strategies equilibria in presence of switching costs by the solution of nonconvex QP problems
Authors: Liuzzi G. , Locatelli M. , Piccialli V. , Rass S.
Published: May 2021

In this paper we address game theory problems arising in the context of network security. In traditional game theory problems, given a defender and an attacker, one searches for mixed strategies which minimize a linear payoff functional. In the problems addressed in this paper an additional quadratic term is added to the minimization problem. Such term represents switching costs, i.e., the costs for the defender of switching from a given strategy to another one at successive rounds of a Nash game. The resulting problems are nonconvex QP ones with linear constraints and turn out to be very challenging. We will show that the most recent approaches for the minimization of nonconvex QP functions over polytopes, including commercial solvers such as and , are unable to solve to optimality even test instances with $$n=50$$

n
=
50

variables. For this reason, we propose to extend with them the current benchmark set of test instances for QP problems. We also present a spatial branch-and-bound approach for the solution of these problems, where a predominant role is played by an optimality-based domain reduction, with multiple solutions of LP problems at each node of the branch-and-bound tree. Of course, domain reductions are standard tools in spatial branch-and-bound approaches. However, our contribution lies in the observation that, from the computational point of view, a rather aggressive application of these tools appears to be the best way to tackle the proposed instances. Indeed, according to our experiments, while they make the computational cost per node high, this is largely compensated by the rather slow growth of the number of nodes in the branch-and-bound tree, so that the proposed approach strongly outperforms the existing solvers for QP problems.
Female reproductive organs of Brassica napus are more sensitive than male to transient heat stress
Authors: Chen Sheng , Saradadevi Renu , Vidotti Miriam S. , Fritsche-Neto Roberto , Crossa Jose , Siddique Kadambot H. M. , Cowling Wallace A.
Published: May 2021

Oilseed rape (Brassica napus L.) is sensitive to heat stress during the reproductive stage, but it is not clear whether the male and female reproductive organs differ in their sensitivity to heat stress. In this study, full diallel crossing experiments were conducted among four genotypes of B. napus under control, moderate and high heat stress conditions for five days immediately before and two days after crossing. General combining ability (GCA), specific combining ability (SCA) and reciprocal effects were analyzed to evaluate the genetic basis of heat stress tolerance in male and female reproductive organs. High female temperature (Tf) and high male temperature (Tm) reduced the number of fertile pods and seeds set per floret, and the significant Tf × Tm interaction indicated that female reproductive organs were more sensitive to heat stress than male reproductive organs. There were no overall GCA, SCA or reciprocal effects across all combinations of Tf and Tm. However, a significant reciprocal × Tf effect was found, suggesting that genotypes differed in their ability to set fertile pods and seeds as Tf increased. The relative heat tolerance of G1 as a female increased as Tf increased, and the relative heat tolerance of G2 as a male decreased as Tf increased. In summary, reciprocal diallel crossing has demonstrated that female reproductive organs of B. napus are more sensitive than male to transient heat stress at the early flowering stage, and genotypes differ in relative heat tolerance in the male and female reproductive organs as Tf increases.
Physiological and environmental control of seed germination timing in Mediterranean mountain populations of Gundelia tournefortii
Authors: Mattana Efisio , Gómez-Barreiro Pablo , Hani Nizar Youssef , Abulaila Khaled , Ulian Tiziana
Published: May 2021

Fruit and seed morphology interact with embryo physiology and environmental conditions to control seed germination timing. This interaction plays a pivotal role in ecosystems with narrow windows for seedling establishment, such as the Mediterranean mountains. In this study, we investigated the germination responses of the secondary capitula (disseminules) ofGundelia tournefortiifrom East Mediterranean mountain populations. When incubated at 15 °C, intact capitula did not reach 20% of final germination, with or without the addition in the germination substrate of GA3(250 mg L−1), while extracted fruits reached 50% of germination, which increased to ca. 70% when treated with GA3. Cold stratification enhanced final germination of the capitula at 15 °C to ca. 65%, although almost half of the initially sown capitula germinated during the second month of stratification at 5 °C. During the stratification at 5 °C, peak puncture force needed to pierce the basal part of the capitula decreased linearly and capitula started germinating after one month, which corresponded to a peak puncture force of 0.41–0.35 N. These findings highlight the presence of mechanical and hormonal components of physiological seed dormancy. The morphology of the disseminules controls seed germination timing, by interacting with cold winter temperatures and starting seed germination only in early winter. These findings not only provide new insights on the reproduction from seeds of this plant, but by highlighting high germination of cold-stratified intact capitula, can also support plant propagation programmes for this key wild edible species, very important for food security and the livelihoods of local communities in the East Mediterranean region.
Student governments in Chinese higher education: reflection on college students’ and student cadres’ political trust
Authors: Huang Wei , Yao Panpan , Li Fan , Liao Xiaowei
Published: May 2021

This paper documents the structure and operations of student governments in contemporary Chinese higher education and their effect on college students’ political trust and party membership. We first investigate the structure and power distribution within student governments in Chinese universities, specifically focusing on the autonomy of student governments and the degree to which they represent students. Second, using a large sample of college students, we examine how participating in student government affects their political trust and party membership. Our results show that student government in Chinese higher education possesses a complex, hierarchical matrix structure with two main parallel systems—the student union and the Chinese Communist Party system. We found that power distribution within student governments is rather uneven, and student organisations that are affiliated with the Chinese Communist Party have an unequal share of power. In addition, we found that students’ cadre experience is highly appreciated in student cadre elections, and being a student cadre significantly affects their political trust and party membership during college.
The potential for parasite spill-back from commercial bumblebee colonies: a neglected threat to wild bees?
Authors: Martin Callum D. , Fountain Michelle T. , Brown Mark J. F.
Published: May 2021

Commercially-reared bumblebee colonies provide pollination services to numerous crop species globally. These colonies may harbour parasites which can spill-over to wild bee species. However, the potential for parasites to spread from wild to commercial bumblebees, which could then lead to parasite spill-back, is poorly understood. To investigate this, parasite-free commercial Bombus terrestris audax colonies, which are used commercially for strawberry pollination, were placed into seasonal strawberry crops for either 6- or 8-week blocks across two key time periods, early spring and early summer. Bumblebees were removed from colonies weekly and screened for the presence of parasites. In the early spring placement, only one parasite, the highly virulent neogregarine Apicystis bombi, was detected at a low prevalence (0.46% across all bees screened). In contrast, all colonies placed in the crop in the early summer became infected. A trypanosome, Crithidia bombi, and A. bombi were the most prevalent parasites across all samples, reaching peak prevalence in screened bees of 39.39% and 18.18% respectively at the end of the experimental period. The prevalence of A. bombi was greater than most UK records from wild bumblebees, suggesting that commercial colonies could enhance levels of A. bombi infection in wild bees through spill-back. Studies on larger geographical scales with different commercial colony densities are required to fully assess spill-back risk. However, seasonal management, to minimise spill-back opportunities, and treatment of commercial colonies to prevent infection, could be implemented to manage the potential risks of parasite spill-back to wild bees.

Implications for insect conservation Our results show that commercial bumblebee populations do pick up infections, most likely from wild bees, and that these infections can reach prevalences where they may pose a threat to wild bees via parasite spill-back. More research is required to clarify the extent of this potential threat.
Modular production control using deep reinforcement learning: proximal policy optimization
Authors: Mayer Sebastian , Classen Tobias , Endisch Christian
Published: May 2021

EU regulations on $$\textit{CO}_2$$

CO
2

limits and the trend of individualization are pushing the automotive industry towards greater flexibility and robustness in production. One approach to address these challenges is modular production, where workstations are decoupled by automated guided vehicles, requiring new control concepts. Modular production control aims at throughput-optimal coordination of products, workstations, and vehicles. For this np-hard problem, conventional control approaches lack in computing efficiency, do not find optimal solutions, or are not generalizable. In contrast, Deep Reinforcement Learning offers powerful and generalizable algorithms, able to deal with varying environments and high complexity. One of these algorithms is Proximal Policy Optimization, which is used in this article to address modular production control. Experiments in several modular production control settings demonstrate stable, reliable, optimal, and generalizable learning behavior. The agent successfully adapts its strategies with respect to the given problem configuration. We explain how to get to this learning behavior, especially focusing on the agent’s action, state, and reward design.
Identity of mass-flowering crops moderates functional trait composition of pollinator communities
Authors: Beyer Nicole , Kirsch Felix , Gabriel Doreen , Westphal Catrin
Published: May 2021

Context

Pollinator declines and functional homogenization of farmland insect communities have been reported. Mass-flowering crops (MFC) can support pollinators by providing floral resources. Knowledge about how MFC with dissimilar flower morphology affect functional groups and functional trait compositions of wild bee communities is scarce.

Objective

We investigated how two morphologically different MFC, land cover and local flower cover of semi-natural habitats (SNH) and landscape diversity affect wild bees and their functional traits (body size, tongue length, sociality, foraging preferences).

Methods

We conducted landscape-level wild bee surveys in SNH of 30 paired study landscapes covering an oilseed rape (OSR) (Brassica napus L.) gradient. In 15 study landscapes faba beans (Vicia faba L.) were grown, paired with respective control landscapes without grain legumes.

Results

Faba bean cultivation promoted bumblebees (Bombus spp. Latreille), whereas non-Bombus densities were only driven by the local flower cover of SNH. High landscape diversity enhanced wild bee species richness. Faba bean cultivation enhanced the proportions of social wild bees, bees foraging on Fabaceae and slightly of long-tongued bumblebees. Solitary bee proportions increased with high covers of OSR. High local SNH flower covers mitigated changes of mean bee sizes caused by faba bean cultivation.

Conclusions

Our results show that MFC support specific functional bee groups adapted to their flower morphology and can alter pollinators` functional trait composition. We conclude that management practices need to target the cultivation of functionally diverse crops, combined with high local flower covers of diverse SNH to create heterogeneous landscapes, which sustain diverse pollinator communities.
Collaborative augmentation and simplification of text (CoAST): pedagogical applications of natural language processing in digital learning environments
Authors: Shardlow Matthew , Sellar Sam , Rousell David
Published: May 2021

The digitisation of higher education is raising significant questions about the impact of artificial intelligence and automation on teaching and learning environments, highlighting the need to investigate how teachers and students can work with new educational technologies in complementary ways. This paper reports results from a pilot study of the collaborative augmentation and simplification of text (CoAST) system, which is online software designed to facilitate the engagement of university students with theoretically-sophisticated academic texts. CoAST offers a digital learning interface that uses natural language processing algorithms to identify words that can be difficult to understand for readers at different ability levels. Course lecturers use their pedagogical content knowledge to add brief annotations to identified words. The software was trialed using a quasi-experimental design with (1) 23 undergraduate Education Studies students and (2) 23 digital and technology solutions students. Results suggest that CoAST offers a digital learning environment that can effectively mediate and enhance pedagogical relationships between teachers, students, and complex theoretical texts.
Unification and mathematical explanation
Authors: Knowles Robert
Published: May 2021

This paper provides a sorely-needed evaluation of the view that mathematical explanations in science explain by unifying. Illustrating with some novel examples, I argue that the view is misguided. For believers in mathematical explanations in science, my discussion rules out one way of spelling out how they work, bringing us one step closer to the right way. For non-believers, it contributes to a divide-and-conquer strategy for showing that there are no such explanations in science. My discussion also undermines the appeal to unifying power in support of the enhanced indispensability argument.
Turmoil over the crisis: innovation capabilities and firm exit
Authors: Grazzi Marco , Piccardo Chiara , Vergari Cecilia
Published: May 2021

This work investigates the relationship between the characteristics and survival probabilities of firms, distinguishing between “involuntary” firm exit and exit by merger and acquisition (M&A). More in detail, we study how, and to what extent, innovation capabilities, as proxied by patents and trademarks, are able to shape, together with standard performance variables, the observed dynamics at the firm level. By using comprehensive data on Italian firms from business registers, we separate the administrative procedures leading to “involuntary” exit from those ending up with an event of M&A. We find that while higher productivity is associated with a lower probability of “involuntary” exit, productivity increases the chances of being the target for M&A. As far as intellectual property instruments are concerned, they tend to reduce the probability of both “involuntary” exit and M&A. However, the relative importance of the two instruments differs according to the exit route: patents are more relevant than trademarks in preventing “involuntary” exit, while the opposite is true for M&A.

Plain English Summary We investigate firm’s exit after a crisis. Overall innovation plays a positive role, but the relative importance of IP depends on the exit route: patents are more relevant than trademarks against “involuntary” exit, while the opposite is true for M&A. We resort to the virtual universe of Italian limited liability firms from manufacturing, trade, and service to investigate the determinants of firm survival over the period 2010–2014. We scrutinize detailed administrative data on significant events occurring to firms to distinguish between events leading to involuntary exit and to M&A. In addition to the evidence on innovation, our results show that higher productivity decreases the probability of “involuntary” exit, yet productivity increases the chances of being the target for M&A. Taken together, these findings warn against a simplistic perspective on exit: the role of innovation and firm characteristics heavily depends on the exit route.
Biodegradation of Natural Rubber: Microcosm Study
Authors: Bosco Francesca , Mollea Chiara
Published: May 2021

In the present work, natural rubber (NR) biodegradation, by means of a microbial consortium, naturally selected in a tyre dump soil, has been evaluated. To this purpose, prepared soil microcosms were incubated for 236 days, at room temperature, and natural light/dark cycles. The effect of primary C-source and fresh soil addition, soil aeration, and humidity maintenance has been monitored by means of microbiological and respirometric analysis, dry weight loss determinations, and SEM micrographs. During the incubation, in biodegradation microcosms (BD), containing NR samples, the produced CO2 was significantly higher than that of biotic controls (BC). Furthermore, after 236 days, a NR dry weight loss of 15.6%, in BD microcosms, was registered, about four-fold higher than that registered in BC control (3.7%). Obtained results confirmed that the naturally selected microbial consortium was able to use NR as the only C-source and to biodegrade it. The positive effect of soil mixing evidenced that the biodegradation process was mainly carried out by aerobic biomass, especially filamentous fungi, as confirmed by microbial counts and SEM observations. Results obtained in the microcosm study provided useful information in terms of soil aeration and nutrient amendment in view of a future biodegradation process scale-up.
Plättchenkonzentrate in der Behandlung von Rotatorenmanschettenläsionen
Authors: Blunier Raphael , Frommer Marvin Lucas , Zumstein Matthias , Schär Michael
Published: May 2021

Hintergrund

Trotz stetiger Verbesserungen bei der Refixationstechnik von Rotatorenmanschettenrupturen (RMR) ist die Rerupturrate mit 26,6 % nach wie vor hoch. Aus diesem Grund wird heute deshalb versucht, die Manschettenheilung zusätzlich mit biologischen Mitteln zu augmentieren. In diese Kategorie fällt die Augmentation mittels Plättchenkonzentraten. Neben der einfachen Gewinnung und Herstellung gibt es für diese autolog gewonnenen Konzentrate relativ tiefe regulatorische Hürden. Dass diese Konzentrate nur Minuten nach der Blutentnahme und Zentrifugation wieder appliziert werden können, ist ein weiterer Vorteil. Der Begriff Plättchenkonzentrate stellt eine große inhomogene Gruppe von verschiedenen Konzentraten mit unterschiedlichen Eigenschaften dar. Bedingt durch unterschiedliche Herstellungsprozesse weist nicht jedes Plättchenkonzentrat die gleichen Eigenschaften auf.

Fragestellung

Ist die biologische Augmentation mit Plättchenkonzentraten bei Rotatorenmanschettenläsionen mit einem verbesserten Outcome verbunden? Wie unterscheiden sich die gängigen Plättchenkonzentratprodukte in ihrem klinischen und radiologischen Resultat?

Material und Methoden

Die Suche fand via PubMed mit Einschluss von 26/289 Studien von 2007 bis 2020 statt.

Ergebnisse und Diskussion

Die Evaluation der heute verfügbaren Studien zeigt, dass nur P‑PRP („pure platelet-rich plasma“) zur biologischen Augmentation von RMR-Refixationen empfohlen werden kann. Hier zeigte sich eine signifikant tiefere Rerupturrate in den P‑PRP-Gruppen. Aber auch in dieser Plättchenuntergruppe sind die Resultate heterogen. Bei der konservativen Therapie von Partialrupturen und Tendinopathien der Manschette zeigt sich kein Benefit nach biologischer Augmentation mittels Plättchenkonzentrate.
How Sustained is Roux-en-Y Gastric Bypass Long-term Efficacy?
Authors: Guimarães Marta , Osório Catarina , Silva Diogo , Almeida Rui F. , Reis António , Cardoso Samuel , Pereira Sofia S. , Monteiro Mariana P. , Nora Mário
Published: May 2021

Purpose

The rate of weight regain after Roux-en-Y Gastric Bypass (RYGB) can hamper the procedure long-term efficacy for obesity treatment and related comorbidities. To evaluate the rate of weight loss and comorbidity remission failure 10 years or more after RYGB surgery.

Materials and methods

Retrospective observational cohort study. Patients submitted to RYGB for obesity treatment at a single centre with 10 years or more after surgery underwent a clinical reassessment.

Results

Among the subjects invited for clinical revaluation (n = 585), only those who performed RYGB and attended the hospital visit were included in the study (n = 281). The pre-operative mean body mass index (BMI) was 44.4 ± 6.1 kg/m2. Mean post-operative time was 12.2 ± 1.1 years. After surgery, mean BMI was significantly lower 33.4 ± 5.8 kg/m2 (p < 0.0001), 29.5% with a BMI < 30 kg/m2. Mean Total Weight Lost (%TWL) was 24.3 ± 11.4%, reaching a %TWL ≥ 20% in 70.1% with a mean %TWL of 30.0 ± 7.0%. Co-morbidities remission rate was 54.2% for type 2 diabetes, 34.1% for hypertension, 52.4% for hyperlipidemia and 50% for obstructive sleep apnea. Early complications rate was 13.2% and revision surgery occurred in 2.8% of patients. Four patients died of RYGB complications within the first 90 days after surgery.

Conclusion

RYGB has a high rate of long-term successful weight loss and obesity-associated comorbidity improvement. Weight loss failure requiring revision surgery occurs in a small proportion of patients. Our data confirms the long-term effectiveness of RYGB as primary bariatric intervention.

Graphical abstract
Multi-featured collective perception with Evidence Theory: tackling spatial correlations
Authors: Bartashevich Palina , Mostaghim Sanaz
Published: May 2021

Collective perception allows sparsely distributed agents to form a global view on a common spatially distributed problem without any direct access to global knowledge and only based on a combination of locally perceived information. However, the evidence gathered from the environment is often subject to spatial correlations and depends on the movements of the agents. The latter is not always easy to control and the main question is how to share and to combine the estimated information to achieve the most precise global estimate in the least possible time. The current article aims at answering this question with the help of evidence theory, also known as Dempster–Shafer theory, applied to the collective perception scenario as a collective decision-making problem. We study eight most common belief combination operators to address the arising conflict between different sources of evidence in a highly dynamic multi-agent setting, driven by modulation of positive feedback. In comparison with existing approaches, such as voter models, the presented framework operates on quantitative belief assignments of the agents based on the observation time of the options according to the agents’ opinions. The evaluated results on an extended benchmark set for multiple options ($$n>2$$

n
>
2

) indicate that the proportional conflict redistribution (PCR) principle allows a collective of small size ($$N=20$$

N
=
20

), occupying $$3.5\%$$

3.5
%

of the surface, to successfully resolve the conflict between clustered areas of features and reach a consensus with almost $$100\%$$

100
%

certainty up to $$n=5$$

n
=
5

.
When imperfect is preferred: the differential effect of aesthetic imperfections on choice of processed and unprocessed foods
Authors: Suher Jacob , Szocs Courtney , van Ittersum Koert
Published: May 2021

Some companies design processed foods to contain aesthetic imperfections such as non-uniformities in shape, color, or texture. Simultaneously, consumers annually discard millions of pounds of unprocessed, safe-to-eat fruits and vegetables owing to aesthetic imperfections. Why design processed foods with aesthetic imperfections when people discard unprocessed foods because of them? Seven studies, including a choice study at a grocery store and an incentive-compatible study, show that the effect of aesthetic imperfections on consumer preferences depends on whether foods are unprocessed or processed. While imperfections negatively influence preferences for unprocessed foods, they positively influence preferences for processed foods. We attribute this preference shift to consumers making opposing inferences about the human care involved in producing aesthetically imperfect processed and unprocessed foods. Building on research highlighting the positive effects of human presence in production, we thus show that perceived care drives food choice. We discuss implications for product design, retail promotion, and sustainability.
How does consumer engagement evolve when brands post across multiple social media?
Authors: Unnava Vasu , Aravindakshan Ashwin
Published: May 2021

Brands allocate their social media advertising across multiple platforms such as Facebook, Twitter, Instagram, and YouTube. Because consumers use multiple social media, brand communications on one platform could generate engagement within the same platform (direct effects) and potentially impact engagement with the brand on the other platforms (spillover effects). Additionally, past engagement with a post on a platform could sustain into the future, thereby improving the longevity of posts (carryover effects). These effects could also vary across platforms. Drawing on recent advertising literature, the authors propose and test differential carryover, spillover, and direct effects within and across social media. The empirical analysis indicates that these effects exist and are significant, supporting the propositions presented. The analysis provides generalizable guidelines to social media marketers on the effectiveness of the various platforms at sustaining a post and at creating direct and spillover effects across other platforms. Finally, the study also exemplifies a resource allocation model for brands to use when allocating their efforts across the various social media platforms to maximize both consumer engagement and the firm’s return on social media investment.
Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1
Authors: Toti Alessandra , Santi Alice , Pardella Elisa , Nesi Ilaria , Tomasini Richard , Mello Tommaso , Paoli Paolo , Caselli Anna , Cirri Paolo
Published: May 2021

Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk between CAFs and cancer cells is essential for tumor progression and aggressiveness. Cancer cells mediate an activation process, converting normal fibroblasts into CAFs, that are characterized by modified expression of many proteins and increased production and release of microvesicles (MVs), extracellular vesicles generated by outwards budding from the cell membrane. Recent evidence underlined that the uptake of CAF-derived MVs changes the overall protein content of tumor cells. In this paper, we demonstrate that tumor activated fibroblasts overexpress Galectin-1 (Gal-1) and consequently release MVs containing increased levels of this protein. The uptake of Gal-1 enriched MVs by tumor cells leads to the upregulation of its intracellular concentration, that strongly affects cancer cell migration, while neither proliferation nor adhesion are altered. Accordingly, tumor cells co-cultured with fibroblasts silenced for Gal-1 have a reduced migratory ability. The present work reveals the key role of an exogenous protein, Gal-1, derived from activated fibroblasts, in cancer progression, and contributes to clarify the importance of MVs-mediated protein trafficking in regulating tumor-stroma crosstalk.
Observing Justice at Guantánamo Bay: Human Rights NGOs and Trial Monitoring at the US Military Commissions
Authors: Lohne Kjersti
Published: May 2021

The article critically considers the role of NGOs at the US naval base in Guantánamo Bay, Cuba. On the basis of observation of pre-trial hearings for the case against Khalid Sheik Mohammed et al.—those allegedly responsible for the September 11 attacks—the article analyses NGOs as trial monitors of the US military commissions set up to deal with ‘alien unprivileged enemy belligerents’. In spite of continued efforts by human rights NGOs and incremental improvements in the military commissions’ institutional arrangements and practice, the article shows how NGOs have become so much a part of the everyday operation of justice at ‘Gitmo’ that they legitimate the military commissions’ claim to be delivering fair and transparent justice.
Brain metastases: new systemic treatment approaches
Authors: Steindl Ariane , Berghoff Anna Sophie
Published: May 2021

Background

Brain metastases (BM) still present a clinical challenge in oncology. Treatment of BM was mainly based on local approaches including neurosurgery and radiation. However, the fraction of patients with asymptomatic BM has risen over the last decade. Recent clinical trials on immune- and targeted therapies showed promising intracranial responses—especially in neurological asymptomatic status. Therefore, systemic treatment presents an emerging therapy approach specifically in patients with asymptomatic BM.

Methods

The present review highlights the recent advances in systemic therapeutic and preventive approaches in BM focusing on the main BM causing tumors: non-small cell lung cancer (NSCLC), melanoma and breast cancer.

Results

Remarkable intracranial efficacies were presented for several next-generation tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors, especially in asymptomatic BM patients. In NSCLC, osimertinib and afatinib presented intracranial response rates over 80%. Osimertinib showed even a potential for primary BM prevention. Considerable intracranial response rates were observed for the combination of dabrafenib and trametinib in BRAF mutated melanoma BM. Combined ipilimumab and nivolumab treatment in asymptomatic melanoma BM even presented with similar intra- and extracranial response rates. In breast cancer, HER2-targeted TKIs like lapatinib in combination with chemotherapy, or trastuzumab deruxtecan monotherapy presented also notable intracranial response rates.

Conclusion

New developments in targeted and immune-modulating therapies have postulated high intracranial efficacies in patients with BM from different solid tumors. However, more BM-specific studies and BM-specific endpoints in registration trials are warranted to underscore the role of systemic treatment in patients with BM.
Customised pressure profiles of made-to-measure sports compression garments
Authors: Ashby Jack , Lewis Martin , Sanchis-Sanchis Roberto , Sunderland Caroline , Barrett Laura A. , Morris John G.
Published: May 2021

The purpose of this study was to make made-to-measure compression garments that elicit pressures within and below clinical standards. The study also examined whether pressures and gradients can be replicated within and between participants’ legs, and between separate compression garment conditions. Ten males volunteered to participate. Based on three-dimensional scans of the participants’ lower body, three different made-to-measure garments were manufactured: control, symmetrical and asymmetrical. Garment pressures were assessed from the malleolus to the gluteal fold using a pressure monitoring device. A root mean squared difference analysis was used to calculate the in vivo linear graduation parameters. Linear regression showed that peak pressure at the ankle in the left and right leg were: control garment, 13.5 ± 2.3 and 12.9 ± 2.6; asymmetrical garment, 12.7 ± 2.5 and 26.3 ± 3.4; symmetrical garment, 27.7 ± 2.2 and 27.5 ± 1.6 (all mmHg, mean ± standard deviation). Pressure reduction from the ankle to the gluteal fold in the left and right leg were: control, 8.9 ± 3.5 and 7.4 ± 3.0; asymmetrical, 7.8 ± 3.9 and 21.9 ± 3.2; symmetrical, 25.0 ± 4.1 and 22.3 ± 3.6 (all mmHg, mean ± standard deviation). Made-to-measure compression garments can be made to elicit pressures within and below clinical standards, and to elicit equivalent pressures and gradients in different participants.
Feasibility of Nitrogen-Enriched Chars as Circular Fertilizers
Authors: Keskinen Riikka , Nikama Johanna , Kaseva Janne , Rasa Kimmo
Published: May 2021

Purpose

Charred materials are low in bioavailable nitrogen (N) due to gaseous losses and the formation of recalcitrant structures during pyrolysis. Enriching chars with N from wastewaters offers a possibility to upgrade the agronomic value of the chars and manage the liquids. For assessing the practical feasibility of the approach, more information on the extent of the retention and release of the loaded N is needed.

Methods

The ammonium-N (NH4-N) retention capacity of chars derived from sewage sludge (SS_A-C), Salix wood (SA), broiler manure (BR) and coal (LG85) was determined via equilibrations in solutions containing 400, 1500 and 5000 mg NH4-N L−1. Plant availability of the loaded N in SS_C, SA and BR was studied in a pot experiment with ryegrass.

Results

Differences in the total N retention of moist chars were small. The amount of N retained increased with increase in the solution N and was at the highest 2–4 g NH4-N L−1 char. In four consecutive ryegrass harvests, the apparent N recoveries were 67, 47 and 34% for SA, BR and SS_C treatments. No slow release of N was observed.

Conclusion

Considering crop production, the amounts of N retained within the studied chars in bioavailable form were small. Chars with a higher N retention capacity would be needed for an efficient cascade from water purification to fertilizer use.

Graphical Abstract
The efficiency of the sand filtration unit mixed with different packing materials in drain water treatment in Egypt
Authors: Ibrahim Khaled Abd el naser I. , Sabry Tarek Ismail M. , El-Gendy Ahmed S. , Ahmed Sayed I. A.
Published: May 2021

In an attempt to improve the quality of the agricultural drain in Egypt for its reuse again in the irrigation, low-cost solution such as sand filter along with/without other filtration media has been used in this research. As a result of that, pilot plant of sand filter mixed with other filtration media was tested for its ability to improve the sand performance in removing the suspended solids and organic matters from agricultural drain water of the Belbeis drain (in Sharkia governorate in Egypt). Sand only, sand mixed with sponge, sand mixed with activated carbon and sand mixed with ceramic cylinders have been tested to find the best media combination and optimum mixing sand/ medium ratio and optimum infiltration rate. The work has been done on four runs. It was found that sand mixed with ceramic cylinders gave the best removal efficiency with respect to total chemical oxygen demand and chemical oxygen demand for solution which were 77, 74%, respectively, whereas sand mixed with sponge had the best removal efficiency with respect to total suspended solids which was 89%. Also, all tested media combination had effluent quality that complied with Egyptian law 48 for the year 1982 regarding the disposal of wastewater into agricultural drains (chemical oxygen demand ≤ 80 mg/l, total suspended solids ≤ 50 mg/l).
Comparison of indices for scaling and corrosion tendency of groundwater: Case study of unconfined aquifer from Mahoba District, U.P. State
Authors: Mankikar Tejas. Y.
Published: May 2021

This paper is an attempt to utilize the various indices available to assess the degree of corrosivity and calcite formation of groundwater sampled from Indian Mk. II handpumps from the district of Mahoba in Uttar Pradesh. The indices used include Langelier Saturation Index, Ryznar Stability Index, Puckorius Scaling Index, Larson-Skold Index, and Potential to Promote Galvanic Corrosion. Corrosivity of groundwater would cause materials used in construction of pipes to leach into drinking water since the same is used for household activities and drinking purposes. Calcite formation would affect the amount of exertion used to manually pump out required quantity of groundwater from the aquifer as it reduces the convey potential of pipes. One hundred five groundwater samples were collected from Indian Mk. II handpumps tapping shallow aquifer (up to 35mbgl) from different locations that were used by locals for analysis of basic parameters like pH, TDS, EC, ions like calcium, magnesium, sodium, potassium, chloride, carbonate, bicarbonate, sulphate, etc. Overall, majority of the groundwater samples display tendency to deposit calcium carbonate within the pipes, chlorides and sulphates not interfering with natural film formation in pipes and possibility of galvanic corrosion, whereas minority of the samples indicate the alternate scenario.
Hydrothermal fabrication and characterization of novel CeO2/PbWO4 nanocomposite for enhanced visible-light photocatalytic performance
Authors: Selvi S. , Rajendran Ranjith , Jayamani N.
Published: May 2021

In this revision, a series of novel visible-light-driven (VLD) CeO2/PbWO4 nanocomposites (NCs) were effectively fabricated by facile hydrothermal preparation way. The UV–Vis absorption spectra exposed that CeO2 NPs prolonged the adsorption edge of the CeO2/PbWO4 composite to the extensive visible region, which allied to decreases of the bandgap. As-prepared CeO2/PbWO4 NCs revealed superior photocatalytic action under visible-light and could degrade the Methylene Blue (MB) dye solution in 140 min. The photodegradation efficacy of CeO2/PbWO4 NCs was improved catalytic activity, which is around 1.45 and 2.7 times that of CeO2 and PbWO4 nanoparticles (NPs) individually. Besides, the CeO2/PbWO4 catalysts display notable stability and reusability performance in four succeeding cycles. The development in the photocatalytic enactment of combined CeO2/PbWO4 nanocomposite could be recognized not only to the sturdy visible-light absorption responses and separating the photoexcited electron–hole pairs. Also, the plausibly systematic illumination of charge transference and exploitation of reactive species for superior photocatalytic action in visible-light have been discussed. It is projected that the CeO2/PbWO4 NCs could be used as effective photocatalysts for promising applications for environmental wastewater refinement.
Pediatric endoscopic pilonidal sinus treatment (PEPSiT): what we learned after a 3-year experience in the pediatric population
Authors: Esposito Ciro , Montaruli Ernesto , Autorino Giuseppe , Mendoza-Sagaon Mario , Escolino Maria
Published: May 2021

This paper aimed to report a multi-institutional 3-year experience with pediatric endoscopic pilonidal sinus treatment (PEPSiT) and describe tips and tricks of the technique. We retrospectively reviewed all patients < 18 years, with primary or recurrent pilonidal sinus disease (PSD), undergoing PEPSiT in the period 2017–2020. All patients received pre-operative laser therapy, PEPSiT and post-operative dressing and laser therapy. Success rate, healing rate/time, post-operative management, short- and long-term outcome and patient satisfaction were assessed. A total of 152 patients (98 boys) were included. Median patient’s age was 17.1 years. Fifteen/152 patients (9.8%) presented a recurrent PSD. All patients resumed full daily activities 1 day after surgery. The post-operative course was painless in 100% of patients (median VAS pain score < 2/10). Patient satisfaction was excellent (median score 4.8). The median follow-up was 12.8 months (range 1–36). Complete healing in 8 weeks was achieved in 145/152 (95.4%) and the median healing time was 24.6 days (range 16–31). We reported post-operatively immediate Clavien grade 2 complications (3 oedema, 2 burns) in 5/152 (3.3%) and delayed Clavien grade 2 complications (3 granulomas, 8 wound infections) in 11/152 (7.2%). Disease recurrence occurred in 7/152 (4.6%), who were re-operated using PEPSiT. PEPSiT should be considered the standard of care for surgical treatment of PSD in children and teenagers. PEPSiT is technically easy, with short and painless post-operative course and low recurrence rate (4.6%). Standardized treatment protocol, correct patient enrollment and information, and intensive follow-up are key points for the success of the procedure.
Correction to: Emotion classification from speech signal based on empirical mode decomposition and non-linear features
Authors: Krishnan Palani Thanaraj , Joseph Raj Alex Noel , Rajangam Vijayarajan
Published: May 2021

A correction to this paper has been published: https://doi.org/10.1007/s40747-021-00377-y