bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation in adverse drug events of opioids in the United States
Authors: Liu Edward Y. , McCall Kenneth L. , Piper Brian J.
Published: March 2023

Background: The United States (US) ranks high, nationally, in opioid consumption. The ongoing increase in the misuse and mortality amid the opioid epidemic has been contributing to its rising cost. The worsening health and economic impact of opioid use disorder in the US warrants further attention. We, therefore, assessed commonly prescribed opioids to determine the opioids that were over-represented versus under-represented for adverse drug events (ADEs) to better understand their distribution patterns using the Food and Drug Administration’s Adverse Event Reporting System (FAERS) while correcting for distribution using the Drug Enforcement Administration’s Automation of Reports and Consolidated Orders System (ARCOS). Comparing the ratio of the percentage of adverse drug events as reported by the FAERS relative to the percentage of distribution as reported by the ARCOS database is a novel approach to evaluate post-marketing safety surveillance and may inform healthcare policies and providers to better regulate the use of these opioids.

Methods: We analyzed the adverse events for 11 prescription opioids, when correcting for distribution, and their ratios for three periods, 2006–2010, 2011–2016, and 2017–2021, in the US. The opioids include buprenorphine, codeine, fentanyl, hydrocodone, hydromorphone, meperidine, methadone, morphine, oxycodone, oxymorphone, and tapentadol. Oral morphine milligram equivalents (MMEs) were calculated by conversions relative to morphine. The relative ADEs of the selected opioids, opioid distributions, and ADEs relative to distribution ratios were analyzed for the 11 opioids.

Results: Oxycodone, fentanyl, and morphine accounted for over half of the total number of ADEs (n = 667,969), while meperidine accounted for less than 1%. Opioid distributions were relatively constant over time, with methadone repeatedly accounting for the largest proportions. Many ADE-to-opioid distribution ratios increased over time, with meperidine (60.6), oxymorphone (11.1), tapentadol (10.3), and hydromorphone (7.9) being the most over-represented for ADEs in the most recent period. Methadone was under-represented (<0.20) in all the three periods.

Conclusion: The use of the FAERS with the ARCOS provides insights into dynamic changes in ADEs of the selected opioids in the US. There is further need to monitor and address the ADEs of these drugs.
Rapid earthquake magnitude estimation combining a neural network and transfer learning in China: Application to the 2022 Lushan M6.1 earthquake
Authors: Zhu Jingbao , Li Shuilong , Li Shanyou , Wei Yongxiang , Song Jindong
Published: March 2023

Introduction: China is one of the most seismically active countries in the world. It is an important task for a Chinese earthquake early warning system to quickly obtain robust magnitude estimation. However, within the first few seconds after P-wave arrival, there is considerable scatter in magnitude estimation for traditional methods based on a single early warning parameter.

Methods: To explore the feasibility of using a convolutional neural network for magnitude estimation in China, establish a magnitude estimation model suitable for China and provide more robust magnitude estimation based on strong-motion data from China, we propose a new approach combining a convolutional neural network and transfer learning (TL) to construct a magnitude estimation model (TLDCNN-M) in this study.

Results and Discussion: Our results show that for the same test dataset, in terms of the mean absolute error and standard deviation of magnitude estimation errors, the TLDCNN-M model has better performance than traditional methods and convolutional neural network models without using TL. Meanwhile, we apply the method to the 2022 Lushan M6.1 earthquake occurred in Sichuan province, China. At 3 s after the earliest P phase, the magnitude estimation error is less than 0.5. With the increase in time after the earliest P phase, the magnitude estimation is close to the catalog magnitude; at 10 s after the earliest P phase, the magnitude estimation error is less than 0.2.
Emergence of spin–charge conversion functionalities due to spatial and time-reversal asymmetries and chiral symmetry
Authors: Kondou Kouta , Otani Yoshichika
Published: March 2023

Spin–charge conversion (SCC) leads to the driving principle of spintronics devices, such as non-volatile magnetic memory and energy harvesting devices from light, sound, and heat to charge current. Recently, controllable SCCs have emerged in materials with spatial- and time-reversal asymmetry as a new route for efficient manipulation and realization of novel functionalities of future spintronics devices. This study overviews the SCC from the fundamental mechanism to the recent research progress in novel materials, such as topological magnets and atomically layered materials. Additionally, we discuss the chiral organic materials from the viewpoint of a new pathway for the emergence of spin functionalities.
CRISPR/Cas9 establishment-mediated targeted mutagenesis in Macrobrachium nipponense
Authors: Qiao Hui , Jiang Sufei , Fu Hongtuo , Xiong Yiwei , Zhang Wenyi , Xu Lei , Cheng Dan , Wang Jisheng
Published: March 2023

Introduction: CRISPR/Cas9 is a gene-editing technology which could specifically cleave dsDNA and induce target gene mutation. CRISPR/Cas9 has been widely used in gene functional studies in many fields, such as medicine, biology, and agriculture due to its simple design, low cost, and high efficiency. Although it has been well developed in model fish and freshwater fish for gene function analysis, it is still novel in the studies dealing with economic crustacean species.

Methods: In this study, we established a CRISPR/Cas9 system based on microinjection for M. nipponense, an important economic crustacean aquaculture species. The vitellogenin (Vg) gene and the eyeless (Ey) gene were selected as the targeted genes for mutation. Two sgRNAs were designed for Mn-Vg and Mn-Ey gene editing, respectively.

Results and Discussion: For sg-Vg-1, the gastrula survival ratio was 8.69%, and the final hatching ratio was 4.83%. The blastula mutant ratio was 10%, and the hatching individual mutant ratio was 30%. For sg-Vg-2, the gastrula survival ratio was 5.85%, and the final hatching ratio was 3.89%. The blastula mutant ratio was 16.67%, and no mutant sequences were detected in hatching individuals. For sg-Ey-1, the gastrula survival ratio was 6.25%, and the final hatching ratio was 2.34%. The blastula mutant ratio was 10.00%, and the hatching individual mutant ratio was 66.67%. For sg-Ey-2, the gastrula survival ratio was 6.00%, and the final hatching ratio was 2.67%. No mutant sequence was detected in both blastula stage and hatching individuals. There were no significant morphological changes observed in the Mn-Vg group. Two deformed types were detected in sg-Ey-1-injected embryos. An evident developmental delay of the compound eye was detected in Ey-sg1-H1 in the zoea stage. The compound eyes of the Ey-sg1-H2 embryo could not form well-defined spheres, and the whole compound eye appeared to diffuse at the end of the late zoea stage. The establishment of a gene-editing platform based on CRISPR/Cas9 will not only provide an efficient and convenient method for gene function analysis but also provide a powerful tool for molecular-assisted breeding of Macrobrachium nipponense.
Dissociation of pulse wave velocity and aortic wall stiffness in diabetic db/db mice: The influence of blood pressure
Authors: McCallinhart Patricia E. , Lee Yong Ung , Lee Avione , Anghelescu Mircea , Tonniges Jeffrey R. , Calomeni Ed , Agarwal Gunjan , Lincoln Joy , Trask Aaron J.
Published: March 2023

Introduction: Vascular stiffness is a predictor of cardiovascular disease and pulse wave velocity (PWV) is the current standard for measuring in vivo vascular stiffness. Mean arterial pressure is the largest confounding variable to PWV; therefore, in this study we aimed to test the hypothesis that increased aortic PWV in type 2 diabetic mice is driven by increased blood pressure rather than vascular biomechanics.

Methods and Results: Using a combination of in vivo PWV and ex vivo pressure myography, our data demonstrate no difference in ex vivo passive mechanics, including outer diameter, inner diameter, compliance (Db/db: 0.0094 ± 0.0018 mm2/mmHg vs. db/db: 0.0080 ± 0.0008 mm2/mmHg, p > 0.05 at 100 mmHg), and incremental modulus (Db/db: 801.52 ± 135.87 kPa vs. db/db: 838.12 ± 44.90 kPa, p > 0.05 at 100 mmHg), in normal versus diabetic 16 week old mice. We further report no difference in basal or active aorta biomechanics in normal versus diabetic 16 week old mice. Finally, we show here that the increase in diabetic in vivo aortic pulse wave velocity at baseline was completely abolished when measured at equivalent pharmacologically-modulated blood pressures, indicating that the elevated PWV was attributed to the concomitant increase in blood pressure at baseline, and therefore “stiffness.”

Conclusions: Together, these animal model data suggest an intimate regulation of blood pressure during collection of pulse wave velocity when determining in vivo vascular stiffness. These data further indicate caution should be exerted when interpreting elevated PWV as the pure marker of vascular stiffness.
Gaussian mixture modeling of acceleration-derived signal for monitoring external physical load of tennis player
Authors: Marutani Yoshihiro , Konda Shoji , Ogasawara Issei , Yamasaki Keita , Yokoyama Teruki , Maeshima Etsuko , Nakata Ken
Published: March 2023

Introduction: With the widespread use of wearable sensors, various methods to evaluate external physical loads using acceleration signals measured by inertial sensors in sporting activities have been proposed. Acceleration-derived external physical loads have been evaluated as a simple indicator, such as the mean or cumulative values of the target interval. However, such a conventional simplified indicator may not adequately represent the features of the external physical load in sporting activities involving various movement intensities. Therefore, we propose a method to evaluate the external physical load of tennis player based on the histogram of acceleration-derived signal obtained from wearable inertial sensors.

Methods: Twenty-eight matches of 14 male collegiate players and 55 matches of 55 male middle-aged players wore sportswear-type wearable sensors during official tennis matches. The norm of the three-dimensional acceleration signal measured using the wearable sensor was smoothed, and the rest period (less than 0.3 G of at least 5 s) was excluded. Because the histogram of the processed acceleration signal showed a bimodal distribution, for example, high- and low-intensity peaks, a Gaussian mixture model was fitted to the histogram, and the model parameters were obtained to characterize the bimodal distribution of the acceleration signal for each player.

Results: Among the obtained Gaussian mixture model parameters, the linear discrimination analysis revealed that the mean and standard deviation of the high-intensity side acceleration value accurately classified collegiate and middle-aged players with 93% accuracy; however, the conventional method (only the overall mean) showed less accurate classification results (63%).

Conclusion: The mean and standard deviation of the high-intensity side extracted by the Gaussian mixture modeling is found to be the effective parameter representing the external physical load of tennis players. The histogram-based feature extraction of the acceleration-derived signal that exhibit multimodal distribution may provide a novel insight into monitoring external physical load in other sporting activities.
Multi-locus genome-wide association study of chickpea reference set identifies genetic determinants of Pratylenchus thornei resistance
Authors: Channale Sonal , Thompson John P. , Varshney Rajeev K. , Thudi Mahendar , Zwart Rebecca S.
Published: March 2023

Pratylenchus thornei is an economically important species of root-lesion nematode adversely affecting chickpea (Cicer arietinum) yields globally. Integration of resistant crops in farming systems is recognised as the most effective and sustainable management strategy for plant-parasitic nematodes. However, breeding for P. thornei resistance in chickpea is limited by the lack of genetic diversity. We deployed a genome-wide association approach to identify genomic regions and candidate genes associated with P. thornei resistance in 285 genetically diverse chickpea accessions. Chickpea accessions were phenotyped for P. thornei resistance in replicated glasshouse experiments performed for two years (2018 and 2020). Whole genome sequencing data comprising 492,849 SNPs were used to implement six multi-locus GWAS models. Fourteen chickpea genotypes were found to be resistant to P. thornei. Of the six multi-locus GWAS methods deployed, FASTmrMLM was found to be the best performing model. In all, 24 significant quantitative trait nucleotides (QTNs) were identified, of which 13 QTNs were associated with lower nematode population density and 11 QTNs with higher nematode population density. These QTNs were distributed across all of the chickpea chromosomes, except chromosome 8. We identified, receptor-linked kinases (RLKs) on chromosomes 1, 4 and 6, GDSL-like Lipase/Acylhydrolase on chromosome 3, Aspartic proteinase-like and Thaumatin-like protein on chromosome 4, AT-hook DNA-binding and HSPRO2 on chromosome 6 as candidate genes for P. thornei resistance in the chickpea reference set. New sources of P. thornei resistant genotypes were identified that can be harnessed into breeding programs and putative candidate P. thornei resistant genes were identified that can be explored further to develop molecular markers and accelerate the incorporation of improved P. thornei resistance into elite chickpea cultivars.
Multi-omics analyses reveal the crosstalk between the circadian clock and the response to herbicide application in Oryza sativa
Authors: Chen Ke , Su Xiao , Yang Haona , Peng Yajun , Wu Lamei , Zhao Zhenghong , Lin Tao , Bai Lianyang , Wang Lifeng
Published: March 2023

Plants have evolved circadian clock systems that enable biological processes to occur in tandem with periodic changes in the environment. However, it is largely unknown whether crosstalk occurs between the circadian clock and the response to herbicide in rice. We identified 19 conserved rhythmic metabolites which were response to pesticide application and their metabolic abundance peaked mainly at ZT2 or ZT14-ZT18. We found a series of glyphosate, s-Metolachlor, fenclorim, metcamifen and GA3 response genes were expressed following stable circadian rhythms. In order to determine the patterns of their temporal expression, co-expression network analysis was done on 10,467 genes that were periodically expressed throughout a 24-hour period. Next, we identified 4,031 potential direct target genes of OsCCA1 in using DAP-seq data for OsCCA1. Of these, 339, 22, 53, 53 and 63 genes showed a response to glyphosate, s-Metolachlor, fenclorim, metcamifen and GA3 application, respectively. And they were mainly phased from dusk to midnight. Interestingly, we identified significant OsCCA1 binding peaks in the promoter regions of four herbicide resistance genes, including OsCYP81A12, OsCYP81E22, OsCYP76C2, and OsCYP76C4. Finally, we found that herbicide application could affects the expression of some of the central oscillator genes of the rice circadian clock. Here, we used multi-omics data to reveal the crosstalk between the circadian clock and herbicide response processes at the epigenomics, transcriptome, and metabolome levels in rice. This work will serve as a theoretical guide for identifying rhythmic herbicide targets, leading to the creation of new herbicides or the breeding of crops resistant to herbicides.
The development of new remote technologies in disaster medicine education: A scoping review
Authors: Kao Chia-Lung , Chien Li-Chien , Wang Mei-Chin , Tang Jing-Shia , Huang Po-Chang , Chuang Chia-Chang , Shih Chung-Liang
Published: March 2023

Background

Remote teaching and online learning have significantly changed the responsiveness and accessibility after the COVID-19 pandemic. Disaster medicine (DM) has recently gained prominence as a critical issue due to the high frequency of worldwide disasters, especially in 2021. The new artificial intelligence (AI)-enhanced technologies and concepts have recently progressed in DM education.

Objectives

The aim of this article is to familiarize the reader with the remote technologies that have been developed and used in DM education over the past 20 years.

Literature scoping reviews

Mobile edge computing (MEC), unmanned aerial vehicles (UAVs)/drones, deep learning (DL), and visual reality stimulation, e.g., head-mounted display (HMD), are selected as promising and inspiring designs in DM education.

Methods

We performed a comprehensive review of the literature on the remote technologies applied in DM pedagogy for medical, nursing, and social work, as well as other health discipline students, e.g., paramedics. Databases including PubMed (MEDLINE), ISI Web of Science (WOS), EBSCO (EBSCO Essentials), Embase (EMB), and Scopus were used. The sourced results were recorded in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart and followed in accordance with the PRISMA extension Scoping Review checklist. We included peer-reviewed articles, Epubs (electronic publications such as databases), and proceedings written in English. VOSviewer for related keywords extracted from review articles presented as a tabular summary to demonstrate their occurrence and connections among these DM education articles from 2000 to 2022.

Results

A total of 1,080 research articles on remote technologies in DM were initially reviewed. After exclusion, 64 articles were included in our review. Emergency remote teaching/learning education, remote learning, online learning/teaching, and blended learning are the most frequently used keywords. As new remote technologies used in emergencies become more advanced, DM pedagogy is facing more complex problems.

Discussions

Artificial intelligence-enhanced remote technologies promote learning incentives for medical undergraduate students or graduate professionals, but the efficacy of learning quality remains uncertain. More blended AI-modulating pedagogies in DM education could be increasingly important in the future. More sophisticated evaluation and assessment are needed to implement carefully considered designs for effective DM education.
Out-of-pocket expenditure and catastrophic costs due to COVID-19 in Indonesia: A rapid online survey
Authors: Hafidz Firdaus , Adiwibowo Insan Rekso , Kusila Gilbert Renardi , Ruby Mahlil , Saut Benyamin , Jaya Citra , Baros Wan Aisyiah , Revelino Dedy , Dhanalvin Erzan , Oktavia Ayunda
Published: March 2023

Background

The Corona Virus Disease 2019 (COVID-19) pandemic has created a substantial socioeconomic impact, particularly in developing countries such as Indonesia.

Purpose(s)/objective(s)

This study aimed to describe the COVID-19-related out-of-pocket spending of Indonesian citizens and the proportion of whom experienced catastrophic health spending during the COVID-19 pandemic using the patient's perspective.

Methodology

We conducted a rapid cross-sectional online survey across provinces in Indonesia to capture participants' experiences due to COVID-19. Data were collected between September 23rd to October 7th of 2021 including demographics, income, and expenditures. Descriptive statistics were used to analyze the respondents' characteristics. Patients's perspective of total cost was estimated from out-of-pocket of COVID-19 direct costs and compared them to total expenditure. If the proportion of COVID-19 total costs exceeded 40% of the total expenditure, the respondents were deemed to have faced catastrophic costs.

Results

A total of 1,859 respondents answered the questionnaire. The average monthly income and expenditure of respondents were 800 USD, and 667 USD respectively. The monthly expenditure was categorized into food expenditure (367 USD) and non-food expenditure (320 USD). The average of COVID-19-related monthly expenditure was 226 USD, including diagnostic expenditure (36 USD), preventive expenditure (58 USD), medical expenditure (37 USD for COVID-19 treatment; and 57 USD for post-COVID-19 medical expenses), and non-medical expenditure (30 USD). Analysis showed that 18.6% of all respondents experienced catastrophic costs while 38.6% of the respondents who had COVID-19 treatment experienced catastrophic costs.

Conclusion

The high proportion of catastrophic costs among respondents suggests the need for COVID-19 social protection, especially for COVID-19 diagnostic and prevention costs. The survey findings have led the government to increase the benefit coverage other than medical costs at the hospitals.
Influence of public hospital reform on public health: Evidence from a quasi-natural experiment in China
Authors: Guo Bingnan , Feng Weizhe , Cai Huilin , Lin Ji
Published: March 2023

Public health is an important symbol of national wealth and prosperity. At present, China's public health is hindered by the poor management of public hospitals, which impacts the demographic structure and socioeconomic development. Therefore, taking the implementation of public hospital reform in China as a quasi-natural experiment, this study employed the time-varying DID model and the mediating effect to evaluate the influence of public hospital reform on public health. The results were as follows: (1) Public hospital reform can significantly improve public health, and a series of robustness tests have also confirmed the effects; (2) Government's financial support is a transmission mechanism for public hospital reform to promote public health; (3) After taking control variables into consideration, the effect of public hospital reform is stronger in the western region with a poorer economy. This research provides a vital policy reference for promoting the scope of reform and improving the health of the general public.
Comparative effectiveness of various physical exercise interventions on executive functions and related symptoms in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis
Authors: Zhu Feilong , Zhu Xiaotong , Bi Xiaoyu , Kuang Dongqing , Liu Boya , Zhou Jingyi , Yang Yiming , Ren Yuanchun
Published: March 2023

Background

Physical exercise has been recommended as an important nonpharmacological therapeutic strategy for managing attention deficit hyperactivity disorder (ADHD). We conducted a network meta-analysis (NMA) to assess the comparative impact of different physical exercise modalities on enhancing executive functions (EFs) and alleviating symptoms in children and adolescents with ADHD.

Methods

We searched Web of Science, PubMed, Embase, Cochrane Central Register of Controlled Trials, SPORTDiscus, PsycINFO, CNKI, and clinical trials databases from inception to October 20, 2022. Randomized controlled trials (RCTs) and quasi-experimental studies investigating physical exercise for ADHD-related symptoms of hyperactivity/impulsivity and inattention, and executive functions were included. The frequentist random-effect NMA method was applied to pool the results.

Results

A total of 59 studies (including 39 RCTs, 5 quasi-RCTs, and 15 self-controlled trials) published between 1983 and 2022 were incorporated into the systematic review, of which 44 studies with 1757 participants were eligible for meta-analysis. All types of physical exercise were effective in improving EFs (SMD = 1.15, 95% CI: 0.83 to 1.46), and open-skill activities which require participants to react in a dynamically changing and externally paced environment induced the most incredible benefits for executive functions (SUCRA = 98.0%, SMD = 1.96, and 95% CI: 1.15 to 2.77). Subgroup analyses for EFs revealed varied findings that open-skill activities were the most promising physical exercise type for improving inhibitory control (SUCRA = 99.1%, SMD = 1.94, and 95% CI: 1.24 to 2.64), and closed-skill activities dominated by aerobic exercises had a slightly higher probability of being the most promising physical exercise intervention for working memory (SUCRA = 75.9%, SMD = 1.21, and 95% CI: −0.22 to 2.65), and multicomponent physical exercise tended to be the most effective in cognitive flexibility (SUCRA = 70.3%, SMD = 1.44, and 95% CI: −0.19 to 3.07). Regarding ADHD-related symptoms, closed-skill activities dominated by aerobic exercises might be more advantageous for hyperactivity/impulsivity (SUCRA = 72.5%, SMD = -1.60, and 95% CI: −3.02 to −0.19) and inattention (SUCRA = 96.3%, SMD = -1.51, and 95% CI: −2.33 to −0.69) improvement.

Conclusion

Physical exercise can significantly help to alleviate the symptoms of ADHD and improve executive functions in children and adolescents with ADHD. Most of all, to promote adherence to treatment, they should be encouraged to perform the physical exercises that they enjoy most.
Associations of migraines with suicide ideation or attempts: A meta-analysis
Authors: Wei Huijie , Li Yu , Lei Hua , Ren Junwei
Published: March 2023

Objective

Whether migraine is associated with a higher risk of suicide ideation and/or attempts remains controversial. Therefore, we aimed to evaluate these potential associations in migraine patients by performing a meta-analysis of previously published data.

Methods

We searched for studies published up to 31 June 2022 that compared the risk of suicide ideation/attempt in migraineurs and non-migraineurs in PubMed, EMBASE, and Web of Science databases. Sixteen studies fulfilled the eligibility criteria. We applied Random-effects models to calculate pooled adjusted odds ratios (AORs) and 95% confidence intervals (CIs) in patients with migraine.

Results

Migraine patients were at a significantly increased risk of suicide ideation (AOR 1.33, 95% CI 1.15–1.54) and suicide attempts (AOR 1.70, 95% CI 1.42–2.03). The increase in risk may be greater in adults (>19 years) than in younger individuals.

Conclusion

The available evidence indicates a significant association of migraines with suicide ideation and attempts. Future work should confirm and extend these findings, as well as explore whether they are affected by ethnicity or geography.
Social isolation and intrinsic capacity among left-behind older adults in rural China: The chain mediating effect of perceived stress and health-promoting behavior
Authors: Su Hong , Xu Lijuan , Yu Hong , Zhou Yuqiu , Li Yang
Published: March 2023

Background

Strengthening and maintaining the intrinsic capacity (IC) of the older adults is the key to preventing and delaying disability and promoting healthy aging.

Objective

This study explores the relationship between social isolation, perceived stress, health promotion behavior, and IC of the left-behind older adults in rural areas and analyzes the chain mediating effect of perceived stress and health promotion behavior among social isolation and IC.

Methods

From March 2021 to May 2022, a multi-stage sampling method was used to recruit participants from rural areas in Heilongjiang Province, China. The data were collected by the simplified version of the Lubben Social Network Scale, the Chinese Perceived Stress Scale, the Health-Promoting Lifestyle Profile-Chinese, and the Integrated Care for Older People (ICOPE) screening tool. We used the PROCESS macro for SPSS to determine the mediating effect of perceived stress and health-promoting behavior between social isolation and IC.

Result

Social isolation score was positively correlated with health-promoting behavior (r = 0.78, p < 0.01) and IC (r = 0.67, p < 0.01), whereas it was negatively correlated with perceived stress (r = −0.63, p < 0.01). Perceived stress was negatively correlated with health-promoting behavior (r = −0.62, p < 0.01) and IC (r = −0.43, p < 0.01). The health-promoting behavior and IC were positively correlated (r = 0.56, p < 0.01). Bootstrapping values indicated that the chain-mediating effect of perceived stress and health-promoting behavior was statistically significant.

Conclusion

Consequently, to improve the IC of the left-behind older adults, we should focus more on reducing the degree of social isolation of the left-behind older adults and improving their perceived stress and health-promoting behavior.
Data quality and associated factors of routine health information system among health centers of West Gojjam Zone, northwest Ethiopia, 2021
Authors: Chekol Afework , Ketemaw Asmamaw , Endale Addisu , Aschale Abiot , Endalew Bekalu , Asemahagn Mulusew Andualem
Published: March 2023

Background

Data quality is a multidimensional term that includes accuracy, precision, completeness, timeliness, integrity, and confidentiality. The quality of data generated by a routine health information system (RHIS) is still very poor in low- and middle-income countries. There is a paucity of studies as to what determines data quality in health facilities in the study area. Therefore, the aim of the present study was to assess the magnitude of the quality of routine health information system data and its determinants among health centers.

Methods

A facility-based quantitative study design triangulated by the qualitative method was conducted. A total of 314 health professionals from 32 health centers were selected using a simple random sampling procedure. Data were gathered using a standardized checklist, interviewer-administered questionnaires, and key informant interview guidelines. Descriptive statistics were used to describe variables and binary logistic regression was used to identify factors associated with data quality using STATA version 14. Variables with p-value <0.25 in the bivariate analysis were entered to a multivariable logistic regression analysis. P-values <0.05 at 95% confidence intervals (CI) were taken to be statistically significant. A manual analysis was conducted for the qualitative data collected from purposively selected key informants.

Results

The study found that the overall data quality at the health centers of West Gojjam Zone was 74% (95% CI 68–78). The complexity of the routine health information system format [adjusted odds ratio (AOR) 3.8; 95% CI 1.7–8.5], problem-solving skills for RHIS tasks (AOR 2.8; 95% CI 1.2–6.4), and knowing duties, roles, and responsibilities were significantly associated with data quality (AOR 12; 95% CI 5.6–25.8), and lack of human resources, poor feedback mechanisms, delay in completing data records, lack of data use, and inadequate training on health information systems were barriers affecting data quality.

Conclusions

The level of data quality among public health centers in the Amhara region was lower than expected at the national level.
Softness presentation by combining electro-tactile stimulation and force feedback
Authors: Suga Yui , Takeuchi Masahiro , Tanaka Satoshi , Kajimoto Hiroyuki
Published: March 2023

To provide realistic tactile sensations in a virtual environment, it is necessary to stimulate both the cutaneous and proprioceptive senses. This study focuses on a realistic method of presenting softness through the use of electro-tactile stimulation. Our system combines a force-feedback device with an electric stimulator to create a soft sensation by applying a reaction force and spreading cutaneous sensation based on the amount of indentation. We measured the change in the contact area of gel samples and used electric stimulation to reproduce the increase in the contact area of the sample. We conducted a psychophysical experiment to evaluate the effectiveness of the combination of cutaneous and force sensations and confirmed that the sensation of softness was enhanced by the simultaneous presentation.
Prognostic factors of adherence to home-based exercise therapy in patients with chronic diseases: A systematic review and meta-analysis
Authors: Ricke Ellen , Dijkstra Arie , Bakker Eric W.
Published: March 2023

Background

Patients with a chronic disease may have an increased risk of non-adherence to prescribed home-based exercise therapy. We performed a systematic review with the aim to identify variables associated with adherence to home-based exercise therapy in patients with chronic diseases and to grade the quality of evidence for the association between these prognostic factors and adherence.

Methods

Cohort studies, cross-sectional studies and the experimental arm of randomized trials were identified using a search strategy applied to PubMed, Embase, PsychINFO and CINAHL from inception until August 1, 2022. We included studies with participants ≥18 years with a chronic disease as an indication for home-based exercise therapy and providing data on prognostic factors of adherence to home-based exercise. To structure the data, we categorized the identified prognostic factors into the five WHO-domains; (1) Patient-related, (2) Social/economic, (3) Therapy-related, (4) Condition-related, and (5) Health system factors. Risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Prognostic factors of adherence were identified and the quality of the evidence between the prognostic factors and adherence were graded using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework for predictor studies. We performed a meta-analysis of the obtained information.

Results

A total of 57 studies were included. Within patient-related factors moderate- and high-quality evidence suggested that more self-efficacy, exercise history, motivation and perceived behavioral control predicted higher adherence. Within social-economic factors moderate-quality evidence suggested more education and physical health to be predictive of higher adherence and within condition-related factors moderate- and low-quality evidence suggested that less comorbidities, depression and fatigue predicted higher adherence. For the domains therapy-related and health-system factors there was not enough information to determine the quality evidence of the prognostic factors.

Conclusion

These findings might aid the development of future home-based exercise programs as well as the identification of individuals who may require extra support to benefit from prescribed home-based exercise therapy.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=277003, identifier PROSPERO CRD42021277003.
Is red cell distribution width a prognostic factor in patients with breast cancer? A meta-analysis
Authors: Yin Jun-Ming , Zhu Ke-Peng , Guo Zhi-Wei , Yi Wen , He Ying , Du Guo-Cheng
Published: March 2023

Purpose

The current study aimed to investigate whether red blood cell distribution width (RDW) can predict the prognosis of patients with breast cancer (BC).

Methods

We searched four databases, including PubMed, Embase, Cochrane Library databases, and CNKI, from inception to Jun 13, 2022. The primary outcome was overall survival (OS), and the secondary outcome was disease-free survival (DFS). A subgroup analysis was conducted based on different treatments. This meta-analysis was performed with RevMan 5.3 (The Cochrane Collaboration, London, United Kingdom).

Results

A total of seven studies including 4,884 BC patients were identified. The high RDW group had a larger tumor size (OR = 2.12, 95% CI = 1.67 to 2.68, P < 0.01), higher proportions of advanced stage tumors (OR = 1.77, 95% CI = 1.38 to 2.27, P < 0.01), more lymph node metastases (OR = 2.00, 95% CI = 1.58 to 2.51, P < 0.01) and lower HER-2 expression (OR = 0.76, 95% CI = 0.61 to 0.95, P = 0.02). For prognosis, after pooling all the data, we found that the high RDW group was associated with worse OS (HR = 2.12, 95% CI = 1.47 to 3.08, P < 0.01) and DFS (HR = 1.77, 95% CI = 1.32 to 2.37, P < 0.01). The subgroup analysis found that RDW had prognostic significance but only for surgery-only patients (HR = 2.41, 95% CI = 1.67 to 3.49, P < 0.01).

Conclusion

High RDW was associated with worse OS and DFS. Therefore, RDW was a simple predictive factor for the prognosis of BC patients.
Stayability in Simmental cattle as affected by muscularity and body condition score between calvings
Authors: Buonaiuto Giovanni , Lopez-Villalobos Nicolas , Costa Angela , Niero Giovanni , Degano Lorenzo , Mammi Ludovica Maria Eugenia , Cavallini Damiano , Palmonari Alberto , Formigoni Andrea , Visentin Giulio
Published: March 2023

The present study aimed to investigate the association between stayability (STAY) traits, muscularity, and body condition score (BCS) in the Italian Simmental dual-purpose cows. Data were collected from 2,656 cows linearly scored in their first lactation from 2002 to 2020 and reared in 324 herds. The binary trait STAY, which is the ability of a cow to stay in the herd, was obtained for each cow-lactation available up to parity 5 (from STAY1-2 to STAY4-5). Analysis of STAY was carried out using logistic regression, considering the fixed effect of energy corrected milk, conception rate, somatic cell score, and muscularity or BCS predicted at different time points. The herd of linear classification and residual error were the random effects. Primiparous cows with a medium BCS and muscularity in early lactation presented a more favorable STAY across life compared to thinner ones (P < 0.05). In fact, cows with an intermediate BCS/muscularity were more likely to stay in the herd after the third lactation (STAY3-4), compared to those presenting a lower BCS/muscularity (P < 0.01). However, cows whose muscularity was high were generally less likely to start the third lactation compared to the others. A potential explanation for this could be the willing to market cows with good conformation for meat purpose. Simmental is in fact a dual-purpose breed known for the good carcass yield and meat quality. This study demonstrates how muscularity and BCS available early in life can be associated with the ability of Simmental cows to stay in the herd.
A Load-Carrying Capacity Evaluation Method for the Welded Joints of Rocket Engine Frame
Authors: Gao Yushan , Huo Shihui , Wang Peiyan , Zhang Ping
Published: March 2023

The load-carrying capacities of welded joints need to be paid attention to in the design of the frame, which transfers the thrust generated by the rocket engine to the rocket body. A load-carrying capacity evaluation method of welded joints based on the structural stress method is proposed in this study. Both the ultimate load-carrying capacity and fracture section angle are precisely obtained by the evaluation method. At the same time, a definition of weld-failure stress is given based on the evaluation method and tests. The load-carrying capacity of welded joints in the rocket engine frame is analyzed through the finite element model, including the overall structure and local weld details. The weld-failure stress of welded joints is obtained based on the analysis of three types of welded structures—standard shear specimen, U-shaped fillet welded specimen and pipe-plate fillet welded specimen. The safety factors of the transverse rod and longitudinal bearing rod welded joints of the frame are 8.6 and 13.4, respectively.
Endophytic Biostimulants for Smart Agriculture: Burkholderia seminalis 869T2 Benefits Heading Leafy Vegetables In-Field Management in Taiwan
Authors: Hung Shih-Hsun Walter , Huang Tsai-Ching , Lai Yu-Chih , Wu I-Chen , Liu Chia-Ho , Huarng Yuh-Feng , Hwang Hau-Hsuan , Chiang En-Pei Isabel , Kuo Chih-Horng , Huang Chieh-Chen
Published: March 2023

Heading leafy vegetables (HLVs) are essential horticultural crops that feed many people worldwide. An increasing global population demands more cropping systems, leading to stresses such as fertilizer overuse and soil salination, decreasing in crop productivity and agricultural sustainability. Hence, developing those eco-friendly farming strategies that could simultaneously reduce fertilizer usage and increase crop harvest is urgent for agriculture. An endophytic bacterium Burkholderia seminalis 869T2 with pyrroloquinoline quinone (PQQ) producing ability were applied as biostimulant for vegetable seedlings under greenhouse or field conditions. Two globally important HLVs, cabbage and head lettuce, were preliminarily tested, and further examinations under in-field farming during two different seasons were carried out to develop an endophytic biostimulants (EBs)-assisted lettuce production system. In this study, we confirmed that B. seminalis 869T2 is versatile EBs for HLVs, which significantly promote plant growth and enhance the qualities of crops by increasing the harvested head weight, size and nutrient composition. Nevertheless, the harvest was accelerated by two weeks, together with higher product qualities and 50% fertilizing cost savings per hectare. Our study provides an in-field EBs-assisted management for lettuce production that could decrease costs and increase the product’s value. The results highlight the importance of endophytic bacteria that deserve further investigation due to their enigmatic symbiotic relationships with their hosts and potential usage in the agro-industry.
Non-Invasive Wildlife Disease Surveillance Using Real Time PCR Assays: The Case of the Endangered Galemys pyrenaicus Populations from the Central System Mountains (Extremadura, Spain)
Authors: Ripa Adriana , Díaz-Caballero José A. , Palacios-González María Jesús , Zalba Javier , Espinosa Antonio , García-Zapata Juan Luis , Gómez-Martín Ana , Tkach Vasyl , Fernández-Garcia José Luis
Published: March 2023

The Iberian desman (Galemys pyrenaicus) is a small semi-aquatic mammal that inhabits mountainous areas from the centre to the north of the Iberian Peninsula and the Pyrenees and is listed as endangered because it has suffered a serious decline. Since 1960, only three species of digeneans (Omphalometra flexuosa, Maritrema pyrenaica and Mathovius galemydis) and two nematodes (Aonchotheca galemydis and Paracuaria hispanica) have been reported from the desman, but no further information on health status and no data from Extremadura has been available. The aim of our study was to characterise the diversity and distribution of parasites and microbiomes of desmans in different areas of the Central System of Extremadura. Between 2019 and 2021 we collected 238 fecal samples and one tissue (intestine) sample that was obtained from a dead desman. DNA templates were processed by commercial or customised real-time PCR using TaqMan probes. Representative data were obtained for Cryptosporidium spp., Omphalometra spp., Eimeria spp., Salmonella spp., Staphylococcus spp. and Leptospira spp. Omphalometra spp. was studied using a newly developed PCR test. The screening of the dead desman allowed us to obtain, for the first time, a partial sequence of the 18SrDNA. This study is the most complete study of the desman, allowing us to identify parasites and the microbiome in populations of G. pyrenaicus using non-invasive sampling.
Differences in Muscle Lipogenic Gene Expression, Carcass Traits and Fat Deposition among Three Iberian Pig Strains Finished in Two Different Feeding Systems
Authors: Garrido Nicolás , Izquierdo Mercedes , Hernández-García Francisco I. , Núñez Yolanda , García-Torres Susana , Benítez Rita , Padilla José Á. , Óvilo Cristina
Published: March 2023

The Iberian pig breed includes several well-differentiated strains. The present study evaluated carcass traits, fat deposition and muscle expression of important lipogenic genes (SCD, ME1, ACACA, FASN, EGR1, ACOX and ACLY) using 65 male pigs of 3 Iberian strains (20 Lampiño, 23 Torbiscal, and 22 Retinto) finished either in a conventional, concentrate-based system (CF) or in montanera (MF), a traditional free-range system with acorn feeding. Torbiscal had the highest ham, Longissimus thoracis and prime cuts yields, and the thinnest subcutaneous adipose tissue (SAT). Retinto had the highest monounsaturated fatty acids (MUFA) and percentage of intramuscular fat (IMF), while Lampiño had the greatest content of saturated fatty acids (SFA), polyunsaturated fatty acids (PUFA), atherogenic (AI) and thrombogenic (TI) indexes in SAT. Conventionally finished pigs had the highest ham, L. thoracis and prime cuts yields, and SFA. Montanera-finished animals had the highest PUFA and MUFA contents, and the lowest AI, TI and n6/n3 ratio in SAT. In relation to gene expression, Retinto had the greatest SCD, FASN and ACLY levels. Most studied genes were overexpressed in CF pigs. In conclusion, MF pigs had healthier fat than CF pigs, and Retinto had the healthiest fat and the greatest lipogenic trend in muscle, supported by IMF and lipogenic gene expression.
Implementation of a Canine Ergonomic Abdominal Simulator for Training Basic Laparoscopic Skills in Veterinarians
Authors: Hincapié-Gutiérrez Luis C. , Oviedo-Peñata Carlos A. , Rojas-Galvis Manuel A. , Riaño-Benavides Carlos H. , Maldonado-Estrada Juan G.
Published: March 2023

The validity of the CALMA Veterinary Lap-trainer simulator (CVLTS) for training basic veterinary laparoscopic skills was assessed and compared to a simple collapsible mobile box trainer. Ten veterinarian surgeons with no experience in laparoscopic surgery and four experts with at least two years of experience in minimally invasive surgery (MIS) were included. The training curriculum included object transfer, non-woven gauze cutting with curved scissors, and interrupted and continuous intracorporeal sutures, which were practiced on the CVLTS. The initial and final assessments were carried out in both the CVLTS and in a collapsible mobile simulator. These were video-recorded and evaluated by external experts using the Objective Structured Assessment of Technical Skills (OSATS) and a specific scale evaluation in a double-blinded schedule. The time, angular displacement, number, and movement smoothness were recorded using a hands movement assessment system (HMAS). Through a survey, the face validity and content were evaluated. The data were analyzed by a Pearson’s proportions comparison or Mann Whitney U test and a bilateral Student’s t-test. The experimental group OSATS, specific scores, and HMAS values, with the exception of the smoothness of movements, significantly improved after training, with no statistically significant differences compared to the expert group. No differences were found between the two simulators. The experts’ and experimental participants’ CVLTS mean score was 4.8. Our data support the CVLTS validations for laparoscopic surgery basic skills training.
Early Milk Total and Differential Cell Counts as a Diagnostic Tool to Improve Antimicrobial Therapy Protocols
Authors: Zecconi Alfonso , Zaghen Francesca , Meroni Gabriele , Sora Valerio , Martino Piera Anna , Laterza Giulia , Zanini Lucio
Published: March 2023

Mastitis is a major cause of antimicrobial treatments either during lactation or at drying off. From a One Health perspective, there should be a balance between the risk of IMI that may impair cow health and welfare and the reduction of antimicrobial usage to decrease antimicrobial resistance, as may happen when applying selective dry-cow therapy. This reduction may be achieved by an early and accurate diagnosis followed by prudent and rationale therapeutical protocols. This study aims to assess the accuracy of PLCC (neutrophils + lymphocyte count/mL) in identifying cows at risk of having IMI due to major pathogens (S.aureus, Str.agalactiae, Str.uberis, and Str.dysgalactiae), and to simulate the impact of this early diagnosis on the potential number of treatments using a decision-tree model. The results of this study showed that PLCC had an overall accuracy of 77.6%. The results of the decision-tree model based on data from the 12 participating herds, with an overall prevalence of major pathogens of 1.5%, showed a potential decrease in the number of treatments of about 30% (from 3.4% to 2.5%) when PLCC in early lactation (days 5–16) was used to identify cows at risk for major pathogens compared with using SCC at the first milk test (days 17–43). The study confirmed that it is possible to improve animal health and reduce the risk of antimicrobial use through early IMI detection based on PLCC and applying a rationale and prudent antimicrobial protocol.