bluuebunny/crossref_metadata_2025 huggingface dataset:
References In The Lyrics Of Nicole Zefanya’s Songs
Authors:   English Department, Udayana University, Devi Sravishta Ayundari , Rajeg I Made ,   English Department, Udayana University, Pratiwi Putu Ayu Asty Senja ,   English Department, Udayana University
Published: October 2023

In the current times, the use of cohesive devices is not only found in formal texts, but also in informal texts such as song lyrics. Accordingly, this study aims to identify the types and to analyze the functions of references from the lyrics of three songs by Nicole Zefanya; “Urs”, “Around”, and “Lose”. This study was conducted using descriptive quantitative method. Documentation method and note-taking technique were used to collect the data. In analyzing the data, this study used the theory from Halliday and Hassan (1976) about grammatical cohesion, to be specific, about reference. The analysis of data was presented using formal and informal method. The results of this study showed that all kinds of reference found in the lyrics of each song of Nicole Zefanya, namely personal reference, demonstrative reference, and comparative reference. Based on the analysis, the data in the lyrics are dominated by personal reference compared to demonstrative reference and comparative reference. In detail, personal reference with 169 occurrences, demonstrative reference with 42 occurrences, and comparative reference with 11 occurrences. Thus, each reference has different functions; as the head of reference, a reference to the previous object, as a modifier, a reference to the following object, a general comparison which refers to things that similar or not similar. Based on the results of this study, reference plays a vital role in establishing coherence, ensuring clarity, and contributing to the overall meaning of the song by connecting the language elements within the lyrics
Morphology Analysis Of Derivational Suffixes Process In The "Walls" Music Album By Louis Tomlinson
Authors:   Udayana University, Putrawan I Wayan , Matradewi Ni Ketut Widhiarcani ,   Udayana University, Aryani I Gusti Agung Istri ,   Udayana University
Published: October 2023

Morphology is the study of linguistics that concerns about words and the structure of words. The aims of this study is to explore derivational morphology process according theory about types of derivational suffix from Plag (2002) in "Walls" music album by Louis Tomlinson. The method that is used in this study is qualitative research because there is no calculation involved and the technique to collect the data is documentation method because the data source is writen text, therefore that is suitable with the method. The data were collected by a music album with the title "Walls" by Louis Tomlinson which contains 12 songs. This study shows that the types of derivational suffix that were found are nominal suffix such as -ion, -ing, -ity, verbal suffix -ize, adjectival suffix such as -ive, adverbial suffix that is -ly. The implication of the study was based on the data, there are derivational suffixes can found in music album, not only in the literary works. From finding derivational suffix data, readers or listeners will understand more about the structure of a word used in the data source and know more about the meaning of each word
The Use Of Homonyms Words In Top 5 Tongue Twister English- Learn English With English Class
Authors:   Dhyana Pura University, Wardhana I Gede Neil Prajamukti , Mambrasar Gina Ivana ,   Dhyana Pura University, Dewi Ni Luh Desy Suari ,   Dhyana Pura University, Utami Gek Wulan Novi ,   Dhyana Pura University
Published: October 2023

The purpose of the study is to determine the types of homonymous words and the meaning of each type of homonymous word in the top 5 Tongue twister English- learn English with English class on the YouTube channel Learning English. The data was analyzed using Parera's (2004) theory. The research design is qualitative, and the data sources for this investigation are the homonyms that appear within the tongue twister. According to the data, there are two types of homonyms: homophones and homographs. There are ten homophones on the video, two in each tongue twister, while there is only one homograph in the "if two witches were to watch two watches, which one would they watch?" tongue twister. It can be concluded that homophones shape the majority of homonyms. Understanding homonym and homograph usage and distinctions in tongue twisters and also to improve the use of pronunciation is the objective of this research
Translation Analysis In Sentence Patterns Found In The Novel Entitled “The Prince”
Authors:   English Department, Bali Dwipa University, juliarta I Made
Published: October 2023

This study aims to: (i) analyze the tree diagram structure of sentence patterns found in the novel entitled “The Prince”, (ii) analyze the types of translation shifts of sentence patterns in the translation process found in the novel entitled “The Prince”. This research focuses on The Syntax Analysis and its Translation Found on Sentence Patterns in the Novel entitled “The Prince”. This study aims at analyzing the tree diagram structure and the types of translation shifts found in the novel entitled “The Prince”. In analyzing data, this study applied the theory of sentence patterns proposed by Quirk and Greenbaum and the theory of translations shift proposed by Catford. In the method and technique of collecting data, the process of collecting data was started by reading the entire data source to get the story in the novel entitled “The Prince” and observe the data of sentence patterns that can be taken from the story entitled “The Prince”. Then, the data source was read to get simple sentence patterns found in the data source. This research study found that there are seven sentence patterns translated by using unit shift of translation proposed by Catford. The researcher applied the theory of syntax, types of sentences, sentence pattern, tree diagram, and reviewed the previous studies. The implication of the study is that it can give the understanding of translation analysis found in the data source and can be used as teaching materials
Preparation, instructional systems, barriers and teachers' efforts in inclusive classrooms: Implementation of limited face-to-face learning during the Covid-19 pandemic
Authors: Rasmitadila Rasmitadila , Effane Anne , Kurniasari Daningsih , Erlina Erlina , Sumarni Dedeh
Published: October 2023

This study explores teacher opinions regarding implementing limited face-to-face learning (LF2FL) in inclusive classrooms during the Covid-19 pandemic in Indonesia. Data were collected for 24 teachers in elementary schools who have taught in the inclusive classroom through semi-structured interviews and analyzed using thematic analysis techniques. The results showed four main themes regarding implementing LF2FL: preparation, instructional systems, barriers, and teacher efforts. Teachers in inclusive classrooms have a heavier workload due to the diverse characteristics of students, mainly students with disabilities who require special treatment in all aspects of achieving learning outcomes. However, the many limitations faced by teachers during the implementation of LF2FL led to teachers' awareness of increasing competence to achieve learning goals for all students. The Indonesian government must readjust the rules for more flexible learning times which have an impact on the learning outcomes of all students in inclusive classrooms.
Sentiment Analysis pada Review Pengguna Aplikasi Snapchat dengan Vader dan Algoritma Machine Learning
Authors: Padel Mohammad Agam  , Muhammad Idzha Adhitya Ranius  , Tata Sutabri  , A. Yani Ranius
Published: October 2023

Perkembangan teknologi hampir di setiap aspek kehidupan, salah satunya pada aspek sosial yang saat ini sangat dipengaruhi dengan perkembangan teknologi digital berupa media sosial untuk berinteraksi dan berkomunikasi dengan orang lain secara online. Terdapat sejumlah media sosial yang digunakan oleh generasi muda saat ini salah satunya media sosial Snapchat yang merupakan sebuah aplikasi media sosial yang digunakan untuk berbagi foto dan video ke daftar penerima dengan pengiriman pesan yang sementara waktu dan cerita yang dapat dilihat dalam jangka waktu terbatas serta fitur unik lainnya yang terus berkembang. Perkembangan sejumlah fitur-fitur pada Snapchat tentunya membutuhkan review dari penggunanya dengan beragam ulasan dan umpan balik dari pengguna sehingga perlu dilakukannya analisis sentimen pada review pengguna aplikasi Snapchat menggunakan pendekatan VADER dan algoritma machine learning. Pada tahap awal penelitian, kumpulan data review berupa Dataset review pengguna aplikasi snapchat hingga labelling data yang kemudian dilakukan tahapan data training dan data testing menggunakan algoritma SVM (Support Vector Machines) sehingga hasil penelitian dapat mengidentifikasi sentimen yang positif, negatif, atau netral dari review pengguna dalam membantu pengembang aplikasi dalam meningkatkan pengalaman pengguna dan mengatasi masalah yang mungkin muncul pada aplikasi Snapchat.
Analisis Kesadaran Keamanan Siber pada Pengguna Aplikasi E-Court di Lingkungan Pengadilan
Authors: Faliandy  , M Yonandio Lazuardi  , Tata Sutabri
Published: October 2023

Penelitian ini bertujuan untuk menganalisis tingkat kesadaran pegawai dan stakeholder terhadap keamanan siber dalam penggunaan aplikasi E-Court di Pengadilan Tata Usaha Negara Palembang. Metode analisis yang digunakan adalah deskriptif kuantitatif dengan menggunakan kuesioner sebagai instrumen pengumpulan data. Hasil penelitian menunjukkan bahwa tingkat kesadaran responden dalam penggunaan aplikasi E-Court tergolong kurang baik, dengan persentase sebesar 42%. Lebih lanjut, ditemukan bahwa sebagian besar responden jarang melakukan penggantian kata sandi aplikasi (73%), bahkan 24% responden tidak pernah melakukannya. Meskipun demikian, kesadaran responden terhadap penggunaan email (68%) dan kejahatan internet (63%) tergolong cukup baik. Dalam rangka meningkatkan kesadaran dan pemahaman responden terkait keamanan siber, pengadilan perlu melakukan upaya pendampingan dan edukasi. Hal ini bertujuan untuk memberikan pemahaman yang lebih baik mengenai pentingnya menjaga keamanan siber, termasuk penggunaan aplikasi E-Court, penggantian kata sandi secara berkala, penggunaan email yang aman, serta upaya pencegahan terhadap kejahatan internet. Dengan adanya upaya pendampingan dan edukasi yang efektif, diharapkan tingkat kesadaran dan pemahaman responden dalam penggunaan aplikasi E-Court dan keamanan siber dapat ditingkatkan. Hal ini akan berkontribusi pada perlindungan data dan informasi perkara yang lebih efektif di Pengadilan Tata Usaha Negara Palembang
Website Sistem Pakar Untuk Diagnosa Penyakit Gigi Pada UPT Puskesmas Babat Toman
Authors: Dwi Indah Lestari  , Prima Sakti Popy , Juliansa Hengki
Published: October 2023

Abstract 

The application to various fields and even has a positive impact on the health sector. Utilization of information technology in the health sector can be used to improve better health services, one of which is to diagnose dental disease. The prevalence of dental and oral health problems in Indonesia is still very high. Of the 57.6% of the population who have dental and oral health problems, it turns out that only 10.2% access dental health services [1]. To overcome these limitations, it’s necessary to make a tool in the form of an expert system to assist the community in making an early diagnosis and preventing more severe diseases. This designed system is based on a website that is used by expert and users, built using the PHP programming language and using MySQL database storage. With the waterfall methodology used in system development, it produces more structured and clear stages. The expert system built results in the process of diagnosing dental and oral diseases using the Forward Chaining method. The research was conducted in the dental field at UPT Puskesmas Babat Toman using a qualitative descriptive method. Research produces a website to help people diagnose dental disease as soon as the symptoms are experienced.

Keywords: website, expert system, dental disease, forward chaining

Abstrak 

Penerapan ilmu komputer telah semakin meluas ke berbagai bidang bahkan memberikan dampak positif pula pada bidang kesehatan. Pemanfaatan teknologi informasi pada bidang kesehatan dapat digunakan untuk meningkatkan pelayanan kesehatan yang lebih baik, salah satunya adalah untuk melakukan diagnosa penyakit gigi. Prevalensi permasalahan kesehatan gigi dan mulut di Indonesia terbilang masih sangat tinggi. Dari 57,6 % penduduk bermasalah kesehatan gigi dan mulut ternyata yang mengakses pelayanan kesehatan gigi hanya 10,2 % [1]. Untuk mengatasi keterbatasan itu perlu dibuat alat bantu berupa sistem pakar untuk membantu kalangan masyarakat dalam mendiagnosa awal pencegahan penyakit yang lebih parah. Sistem yang dirancang ini berbasis website yang digunakan oleh pakar dan masyarakat, dibangun dengan menggunakan bahasa pemrograman PHP dan menggunakan penyimpanan database MySQL. Dengan metodologi waterfall yang digunakan dalam pengembangan sistem, menghasilkan tahap-tahap yang lebih terstruktur dan jelas. Sistem Pakar yang dibangun menghasilkan proses diagnosis penyakit gigi dan mulut menggunakan metode Forward Chaining. Penelitian dilakukan di Bidang Poli Gigi pada UPT Puskesmas Babat Toman menggunakan metode deskriptif kualitatif. Penelitian menghasilkan suatu website untuk membantu masyarakat dalam mendiagnosa penyakit gigi secepat atas gejala yang dialami.

Kata kunci: website, sistem pakar, penyakit gigi, forward chaining
Penerapan NodeMCU Pada Alat Pemberian Minum Hewan Ternak
Authors: Ummul Khair  , Suriati
Published: October 2023

Air minum merupakan faktor yang sangat mempengaruhi dalam menentukan keberhasilan peternakan khususnya pada peternakan ayam. Wadah minum ayam tidak boleh dalam keadaan kosong dan sebaliknya wadah tidak boleh diisi penuh. Hasil perkembangan teknologi saat ini salah satunya adalah teknologi pengendalian berbasis mikrokontroler dalam otomatisasi sistem sistem pemberian minum ayam ternak yang sehingga dapat membantu peternak dalam mempermudah tugasnya. Tujuan penelitian ini adalah untuk menghasilkan alat pengisian air minum secara otomatis pada hewan ternak khusunya ternak ayam dengan penerapan nodeMCU, hal ini dilakukan agar para peternak ayam mudah memberikan minum pada ayam ternak dengan monitoring menggunakan smartphone terhadap air minum pada kandang ayam. Dengan adanya alat air minum otomatis peternak dapat dengan mudah memonitoring air minum ayam dikandang ayam dengan mudah tanpa harus datang kekandang ayamnya.
An Evaluation of the Educational Games Implementation Process from the Teacher Candidates, Students and Parents’ Perspective
Authors: Er Nas Sibel , Yaman Havva
Published: October 2023

The aim of the study is to evaluate the educational games implementation process from the science teacher candidates, students and parents perspective. The special case method, which allows evaluating an event in depth, was preferred. The implementation process was completed in 14 weeks. The study group consists of 36 science teacher candidates, 44 students and 43 parents of students. Interview and open-ended questionnaire were used as data collection tools. The data obtained from the interviews and open-ended questionnaire were analyzed by content analysis. Within the scope of content analysis, the data were coded and categorized and themes were found. The fact that students mostly emphasized the "learning by having fun" code regarding the implementation process of educational games also shows parallelism with the theoretical background of the adoption of games in the education field. Similar to the evaluations of the students, parents and science teacher candidates also emphasized that educational games are fun and instructive. Students think that the educational games make it possible to reinforce the knowledge they have learned. Unlike the students, the parents and teacher candidates evaluated the subject as "repeating the subject by having fun". It can be recommended to apply this study as a group in the classroom and to evaluate educational games in this way.
Role of Venous Blood Gase (VBG) Analysis in Patient Triage in the Adult Emergency Department
Authors: Alwosibei Ahmed , Alqurashi Hanan , Alghazwi Mohammed
Published: October 2023

Background:
In emergency and critical care settings, can a venous blood gas analysis improve clinical decision-making and patient outcomes?
Methods:
This is a cross-sectional study, conducted between January and June 2022 at a tertiary hospital in Saudi Arabia. 
Results:
A total of 100 patients were included, using a convenience sample technique. Their mean age was 54 years, and theirmain chief complaints were shortness of breath (30%), abdominal pain (15%), and altered level of consciousness (14%). The venous blood gas (VBG) result was abnormal in 86 patients, and predicted the need for early intervention in 69 patients (69.7%). A significant association was found between patients requiring early intervention and those with an abnormal VBG (p=0.0005). Furthermore, the VBG results changed the Canadian Triage and Acuity Scale (CTAS) level in 32 patients (33.68%). A logistic regression analysis revealed that pre-testing factors such as age, gender, comorbidities, and chief complaints were not predictors of VBG results, the need for early intervention, or altered CTAS level.
Conclusion:
Our study concludes that VBG analysis can play an important role in patient triage in the emergency department (ED), allowing for earlier intervention and potentially improving outcomes.
Impact of Digital Marketing on Consumer Buying Perspectives in the Pakistan Market
Authors: Batada Imran
Published: October 2023

Digital marketing (DM) has taken the world from conventional marketing to Information and Communication Technology enabled tools to reach consumers. Since the advent of digital marketing, research has been conducted to evaluate how DM shaped customer buying behavior and decisions in developing countries but its impact on developing countries' consumers has been inconsistent. Therefore, this study assesses the impact of DM and its platforms on the buying perception of Pakistani consumers. The data was collected through an online survey of consumers in Pakistani markets. The study showed social media having the highest persuasion power, with Instagram being the most effective in DM influence on buying perceptions of consumers, particularly among young people aged 18-32, followed by mobile marketing and the least SEO. This study provided empirical grounds to support that DM has changed the way Pakistani consumers buy things and this implies that to effectively reach consumers in Pakistan, DM space must be maximized. Based on the study, digital marketing has significantly transformed the purchase decisions made by Pakistani customers. Organizations must prioritize enhancing their digital marketing presence to effectively reach and engage these customers. Platforms like Instagram possess immense persuasive power, which businesses should leverage to persuade and sell their products successfully. This research also holds practical implications for Pakistani marketers and companies, such as understanding how social media platforms shape customer viewpoints. Marketers can utilize this knowledge to target and engage younger demographics. Marketers should incorporate mobile marketing methods due to the prevalence of smartphone usage among Pakistani consumers.
Protective effect of Cordia myxa leaves extract in FCA-induced arthritis in rats
Authors: Kaur Chahal Jasmeet , Chaudhary Jasmine , Chauhan Samrat , Jain Akash , Dhingra Ashwani , Chopra Bhawna
Published: October 2023

Background: Arthritis, an age-related chronic inflammatory autoimmune disease primarily characterized by joint pain, swelling, stiffness, cartilage destruction, is increasing tremendously at an alarming rate and also becoming a major risk factor for other health complications. Cordia myxa, family Boraginaceae is an herbal plant used since ancient times for its various significant pharmacological activities, including anti-inflammatory effects. Scientific studies reporting anti-arthritic potential of leaves extract of this plant are still lacking. Therefore, the present work has been designed to investigate the protective effect of ethanolic extract of Cordia myxa leaves in Freund’s complete adjuvant (FCA)-induced arthritis in rats. Methods: Ethanolic extract (100mg/Kg, 200mg/Kg and 400mg/Kg) was investigated for their efficacy in the management of FCA induced arthritis in rats. Various parameters like paw volume (using plethysmograph), paw thickness (using Vernier calliper), body weight, hematological and histopathological profile were observed. The protocol was approved by Institutional Animal Ethical Committee (MMCP/IAEC/94) and was according to CPCSEA guidelines. Results: The phytochemical screening reveals the presence of flavonoids, glycosides, alkaloids, saponins and carbohydrates in the ethanolic extract of Cordia myxa leaves. Promising results with significant improvement were discovered as evident from all determined parameters when compared with standard drug methotrexate, which might be due to the presence of flavonoids, glycosides, alkaloids in the ethanolic extract of Cordia myxa leaves. Conclusion: The present study supports the traditional use of Cordia myxa leaves as potential anti-arthritic agent which can be effective in Freund’s complete adjuvant (FCA)-induced arthritis in rats, however its mode of action is still need to be studied.
Comparative Antimicrobial and Antioxidant potential of leaf extracts of Aegle marmelos from different regions of Himachal Pradesh
Authors: Thakur Gaurav , Kumar Vikas , Sourirajan Anuradha , Dev Kamal
Published: October 2023

Aegle marmelos (Rutaceae) also called as Bael is an important medicinal plant of Himalayan region. The present study aimed to evaluate the antioxidant and antimicrobial activity of different solvent extracts (n-hexane and ethanol) A. marmelos leaves from different locations of Himachal Pradesh. All the extracts were tested for the antioxidant potential by DPPH radical scavenging and FRAP assay and antimicrobial activity against Gram positive (Staphylococcus aureus), Gram negative (Escherichia coli, Klebsiella pneumoniae) bacterial and fungal strains-Candida albicans (ATCC90028) and C. albicans (MTCC277) using broth dilution method. Significant variation in antioxidant potential was observed in the ethanolic extract of A. marmelos leaves from eight different locations of Himachal Pradesh. Ethanolic extract of Mandi (M3) region showed comparatively more antioxidant potential as revealed from lower IC50 value in DPPH (14.77µg/ml) in comparison to leaves extract of other districts; whereas n hexane extract of Bilaspur (B2) showed higher FRAP activity as shown by lower IC50 value (6.62µM) as compared to leaves extracts of other districts. Antioxidant potential of ethanol extract was slightly higher than that of n-hexane for all the populations of A. marmelos. Ethanolic extracts of Sirmour district (SM1) showed lowest Minimum Inhibitory Concentration (MIC) (7.81µg/ml) against S. aureus, ethanolic extract of Mandi (M3) showed lowest MIC (7.81µg/ml) against E. coli, whereas n-hexane extracts of Chamba (CH1) and Una (U2) showed lowest MIC value (7.81µg/ml) against K. pneumonia. The n-hexane extract of Solan (SO3), ethanolic extract of Kangra (K2), ethanolic extract of Chamba (CH3) showed least MIC (31.25µg/ml) against C. albicans (ATCC90028), whereas ethanolic extracts of district Mandi (M3) showed lowest MIC (31.25 µg/ml) against C. albicans (MTCC277). From the current study it may be concluded that leaf samples of A. marmelos from Mandi district has comparatively more antioxidant potential among all other samples, whereas comparative variation in antibacterial and antifungal activity of A. marmelos leaves from different geographical regions was observed.
Formulation and Stability of Orally Fast Disintegrating Tablets of Amlodipine besylate
Authors: Thi Huynh My-Duyen , Thi Le Minh-Ngoc , Tran Quang-Thinh , Dang Duy-Khanh
Published: October 2023

The demand for fast disintegrating tablets has been growing during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Amlodipine besylate is commonly used for the treatment of chest pain, commonly known as angina, due to ischemia of the heart muscle and a result of obstruction or spasm of the coronary arteries. The study would involve the use of various disintegrants along with other excipients for the formulation of orally fast disintegrating tablets to achieve rapid disintegration and release. The stability studies of the prepared dosage form would be carried out according to the guideline of the ASEAN guideline. In this study, we researched on formulating orally fast disintegrating tablets containing 5 mg of amlodipine at pilot scale. Fast-dissolving amlodipine tablets were prepared by direct compression method. Formulations were designed by Design Expert v11 using D-optimal model and optimized by BC-PharSoft OPT software. Studied ingredients are disintegrants and fillers for directly compressed tablets. After successfully developing the optimal formulation, the batch size was scaled up to 10.000 tablets. Then the tablet stability study was proceeded and shelf life of the product under accelerated conditions was determined within 6 months according to Van’t Hoff principle. It was revealed that tablets had good stability and shelf life of 766.3 days (at 30oC). This satisfactory result may show a great promise for large-scale production.
Evaluation of Iron Deficiency in OSMF patients: A Cross-sectional Study
Authors: Rao Deshpande Kopparesh , Ray Subhashree , Kumar Panda Swarup , Behera Sudeshna , Kumar Tripathy Subrat , Sahu Samir
Published: October 2023

Oral submucous fibrosis is a type of chronic oral pathological ailment, which is having insidious onset. It possesses high rate of malignant transformation, which gets accentuated by pernicious oral habits like chewing of areca nut in betel. OSMF predisposes to marked hematological abnormalities, leading to anemia and reduction in levels of serum iron and proteins. The aim of this study was to measure the hemoglobin, serum iron and protein levels among OSMF patients and also to compare these parameters with healthy controls.In the hospital-based study, among 100 study subjects, 45 OSMF patients were selected as cases, whereas 55 apparently healthy individuals were chosen as controls. The hemoglobin, serum iron and protein levels were estimated using hematological and biochemical autoanalyzers. Significantly lower levels of hemoglobin, serum iron, and protein levels were observed in OSMF patients in comparison with apparently healthy subjects.Findings of this study focus on the necessity and rationale of assessing hemoglobin, serum iron and protein amongst OSMF patients. These biochemical assessments in the precancerous condition of OSMF may help in early diagnosis and prognosis. Besides that, iron therapy should be initiated at the earliest with the initial diagnosis, which can be helpful to check further deterioration of the aforesaid premalignant condition. Further extensive studies are required for fine delineation of hematological alterations in OSMF patients.
In-Silico Prediction of Phytoconstituents from Phyllanthus niruri for Anticancer Activity against Prostate Cancer Targeting MRCK kinases
Authors: P. Motghare Apeksha , P. Katolkar Parimal , S. Lichade Tina
Published: October 2023

Objective: Prostate cancer is a disease in which the malignant cells form in the tissues of the prostate. Once more, medicinal plants are being researched for the treatment of lung cancer. Prototypical compounds found in medicinal plants have been the source of many conventional medications. In-silico testing of Phyllanthus niruri phytoconstituents for anticancer efficacy was a part of our investigation. Design: Utilizing Discovery studio, molecular docking is done to assess the pattern of interaction between the phytoconstituents from the Phyllanthus niruri plant and the crystal structure of the anticancer proteins (PDB ID: 5OTE). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that luteolin (-8.2kcal/mol), and caffeic acid (-6.5kcal/mol), for 5OTE macromolecule has best binding affinity towards MRCK for anticancer activity on prostate as compared to the standard drug lenvatinib mesylate (-3.4kcal/mol). Furthermore, pharmacokinetics and toxicity parameters were within acceptable limits according to ADMET studies. Conclusion: Results from the binding potential of phytoconstituents aimed at anticancer activity were encouraging. It promotes the usage of Phyllanthus niruri and offers crucial details on pharmaceutical research and clinical care.
Meridine and Xestosaprol M have Potential Anti-Virus Resembling Remdesivir
Authors: Setianingsih Herin , Yatmasari Erina , Ilmawan M. Fathi
Published: October 2023

The rise and fall of the COVID-19 wave continue to be watched because the right antiviral drug has not yet been found. Remdesivir is an antiviral drug that is much sought after, especially when the number of COVID-19 cases is spreading worldwide. Until now, the US Food and Drug Administration (FDA) and the Drugs Controller General of India (DCGI) have confirmed the treatment for COVID-19 infection is remdesivir; because of that, remdesivir is very expensive and difficult to find, so that other similar or alternative drugs are needed. Even better ones with better potential too. Based on studies, insilico meridine and xestosaprol M have the same potential as remdesivir as an anti-COVID-19 virus.
Impact of ABO/Rhesus (D, C, c, E, e) blood type on development of vascular complications in type 2 diabetes
Authors: Shalhawi Bayan , Joha Mohamad Sami
Published: October 2023

Introduction: Many studies on type 2 diabetes had conflicting results about the prognostic importance of the ABO or Rhesus (Rh) D expression, and in this context, the other important types of Rh were never studied. Objective: The purpose of this study was to investigate whether ABO and Rh phenotype has an association with vascular complications in type 2 diabetes. Methods: 390 individuals were included in this study (194 were type 2 diabetic patients and 196 were healthy persons). 159 of diabetic patients were classified into two groups: group DC which included 98 diabetic patients with vascular complications, and group D which included 61 diabetic patients without vascular complications. A slide agglutination test was done to determine the ABO and Rh types. Results: While no difference was observed between the frequency of any ABO or Rh types between patients and healthy people, the frequency of A-type and each Rh+ type was higher in the DC group compared to the D group. In addition, the prevalence of the Rh DCceand Rh DcEphenotypes was higher in the DC group. Conclusion: Determining the phenotype of the Rhesus blood group may be a cheap and easy prognostic test for vascular complications development in type 2 diabetes.
Antioxidant, Antiproliferative, Pro-apoptotic and cell cycle arrest properties of crude extract and biofractions of Hybanthus enneaspermus Linn. to combat breast cancer
Authors: Fernandese Mendonca Liesl Maria , Bhimrao Joshi Arun , Bhandarkar Anant , Joshi Himanshu
Published: October 2023

Objective: According to the World Health Organisation, breast cancer is presently the most common cancer diagnosed in women globally. Polyphenolic compounds act as antioxidants, improve health, and reduce risk and proliferation of various types of cancers. Hybanthus enneaspermus Linn. is a beneficial medicinal plant, reported to possess antimicrobial, antioxidant, anti-inflammatory, neuroprotective, cardioprotective, and nephroprotective properties etc. Methods: The current study involved the evaluation the antioxidant, antiproliferative, apoptotic and cell cycle arrest potential of the ethanolic leaf extract of Hybathus enneaspermus Linn. (EEHE), its toluene soluble, toluene insoluble, ethyl acetate and methanol soluble biofractions viz. TFHE, ITHE, EFHE, and MFHE to combat breast cancer. In vitro antioxidant activities were evaluated using DPPH, Hydrogen peroxide, Nitric oxide and ABTS free radical scavenging assays. In vitro antiproliferative activity against MCF-7 cells was assayed using the Sulforhodamine method, while apoptosis and cell cycle assays were analysed by flow cytometry. Results: MFHE exhibited significant in vitro antioxidant activity with IC50 values of 21.10±0.39 μg/mL and 25.99±4.66μg/mL, when compared against standard ascorbic acid with IC50 values of 11.19±1.09 μg/mL and 9.30±0.26μg/mL in DPPH and nitric oxide assays respectively. EFHE displayed substantial antioxidant potential in ABTS and hydrogen peroxide assays with IC50 values of 40.38±0.88μg/mL and 99.11± 13.59μg/mL, while ITHE showed considerable activity with IC50 < 100μg/mL in DPPH, nitric oxide and ABTS assays. TFHE demonstrated significant antiproliferative activity by sulforhodamine assay, with GI50 value of 10.22 6.72µg/mL, while EEHE and ITHE showed substantial activity with GI50 values of 41.42±3.74µg/mL and 64.37±7.07µg/mL respectively, as against the standard drug Adriamycin (GI50 < 10µg/mL) used. In the apoptosis assay, ITHE showed 11.31±0.82% cells in late apoptosis and 34.48±1.57 % cells in necrosis as compared to standard Adriamycin indicated 13.67±1.02 % cells in late apoptosis and 8.58±0.65 % cells in necrosis. In cell cycle analysis, ITHE displayed significant apoptotic activity with 20.15±1.37 % cells in SubG1 phase and 13.99±1.65 % cells arrested in G2-M phase as compared to the control. Conclusion: The study thus revealed that MFHE, EFHE and ITHE biofractions showed significant antioxidant activities, while EEHE, TFHE and ITHE exhibited substantial antiproliferative activity against mammary cancer cells. Additionally, ITHE induced remarkable apoptotic activity and cell cycle arrest in the MCF-7 cells. The therapeutic benefits may be credited to the bioactive constituents present in the ITHE fraction viz. polyphenolics, flavonoids etc.; however, the molecular mechanisms may need to be evaluated further.
Effect of tempering temperature on microstructures and hardness of steel SUS440B for making knives
Authors: Nguyen Ngoc Minh
Published: October 2023

Steel SUS440B is often used to make knives because of its high hardness, corrosion resistance and wear resistance. In order to achieve the above advantages, the steel needs to be treated with a suitable heat treatment process (quenching + tempering), in which the tempering temperature is known as one of the important parameters to control the microstructure and mechanical properties of the steel after quenching. To systematically study the influence of tempering temperature on the microstructure and hardness, the alloy steel was quenched at 1080 oC, then tempered at 160, 240 and 320 oC for 1 hour with tempering times varying from 1 to 3. The results showed that, after 2 times tempering at 160 oC, the highest obtained hardness is 59.5 HRC. If the tempering temperature and number of tempering times increased, precipitation and the accumulation of Cr carbide particles lead to decreasing hardness value.
Enhanced microhardness of Al – 5 wt.% TiC composite by alloying with Cu
Authors: Bui Duc Long , Le Hong Thang , Dang Quoc Khanh , Le Thi Bang , Le Cong Dinh
Published: October 2023

Alumium (Al) – based materials are highly demanded for automobiles, transportation, and aerospace etc. In this research, Al – based TiC composites were fabricated using powder metallurgy (P/M) technology from Al, Cu, and TiC powders with the compositions of Al – 5 wt.% TiC, and Al – 5 Cu/ 5wt.% TiC. The composite powders were well mixed and compacted using cold pressing technique with an applied pressure of 500 MPa. The compacted samples were sintered at 550 oC in Ar atmosphere for 1 h. The distribution of TiC particles in the Al matrix was observed using scanning electron microscopy (SEM). The phase formation of sintered composite was characterized using Xray diffraction (XRD). The results showed that TiC particles homogeneously distributed in the Al matrix. The density of Al -5 wt.%TiC and Al – 5 Cu/ 5 wt.%TiC composites achieved 96.7 and 98.0 % of theoretical density, respectively. The microhardness of pure Al increases from 27 HV to » 38 HV when reinforcing with 5 wt.% TiC, whilst that of the Al – 5TiC composite increase to » 55 Hv when alloying with 5 wt.% Cu.
Effect of Al contents on the properties of AlxNbCrMoV high entropy alloy sintered by the isostatic hot pressing
Authors: Luong Van Duong , Nguyen Huy Dan , Doan Dinh Phuong , Nguyen Ngoc Linh , Dang Quoc Khanh
Published: October 2023

In this work, AlxNbCrMoV (x: 0; 0,1; 0,5 và 1,0) high entropy alloys (HEAs) were produced via a Hot Isostatic Pressing (HIP) technique using a low carbon steel capsule. The effect of Al contents on the structure and mechanical properties of HEA samples was investigated. The results of X-ray diffraction showed the produced HEA samples displayed a single-phase matrix of body centered cubic structure. SEM observation found that the oxide particle sizes of matrix of HEA samples lied in the range of 2.5÷3.5 µm. The Vickers hardness of HEA samples increased with increasing the Al contents from 0.1 to 1 because of the increase of Al2O3 particles. Furthemore, Xray diffractogram at 800 oC showed that the AlNbCrMoV HEA samples have the highest oxidation resistance. These results are expected to open the application of HEA material for refractory uses.
Effects of titanium addition on austenite grain size and mechanical properties of high manganese steel
Authors: Nguyen Hong Hai , Ha Minh Tan , Nguyen Danh Trung
Published: October 2023

Manganese steels have been widely used in industries due to their good wear resistance, high work hardening ability, and high toughness and ductility. This research investigated the effect of modification, i.e., FeTi and Mischmetal, on the grain size and mechanical properties of the high manganese steel (13–15 wt.%). The alloys are modified at different temperatures of 1500, 1550, and 1600 o. The modified alloys were heat-treated after solidification by a two-step process. The grain size, chemical composition, and phase formation of the heat-treated steel were characterized by Optical Microscopy, X-ray Diffractometry, and Energy-Dispersive X-ray Spectroscopy. The mechanical properties of the steel, such as Brinell hardness, tensile strength, and toughness, were measured. As a result, the grain size of the heat-treated alloys is smaller compared to that of un-modified alloys and decreases with the increase in modification amount. The addition of Ti reduced C in the austenite phase by forming very stable carbides, TiC. Maximum tensile strength of 780 MPa was achieved with the addition of 0.1 wt.% Ti, while maximum fracture toughness was 140 J/cm2 at 0.05 wt.% Ti.
Effects of temperature gradient on precipitation in liquid Si-Ti-C
Authors: Ha Minh Tan , Pham Mai Khanh
Published: October 2023

The mechanical properties of alloys and castings strongly depend on the formation of their microstructure. Heat treatment conditions have a directly effect on the grain size. Typically, smaller grain sizes result in improved mechanical properties. To achieve small grain sizes, a commonly applied method is rapid cooling, known as quenching. During the cooling process, there is always a temperature gradient within the casting, which can affect the formation of the microstructure. This study investigates the influence of temperature gradient on the size and morphology of the grains. The results show that at lower temperature gradients, the formed microstructure has a spherical shape. Increasing the temperature gradient leads to greater grain deformation.
Effect of heat-input and post-weld heat treatment on residual stress and deformation of butt welded joint made by structural carbon steel A516 grade 70
Authors: Tran Thi Xuan , Vu Dinh Toai
Published: October 2023

Residual stress and welding deformation are unfavorable factors and always exist in the welded joint. They seriously reduce the working capacity of the welded structure, and at the same time disfigure the aesthetics of the welded structure. Therefore, knowing the influence of the welding parameter, specifically the heat-input, on the residual stress and deformation of the welded joint is of great significance, helping to determine the appropriate welding parameter for each specific welding joint. Welding deformation can be easily measured with common measuring instruments, but determining the residual stress in the welded joint by experiment encounters many difficulties, especially in the interior of the material, so this study proposes a solution to determine the residual stress as well as welding deformation by numerical simulation using SYSWELD software with the least cost and fastest time. The research results show that when welding with a higher heat-input, the residual stress in the welded joint will be greater, causing the longitudinal and transverse deformations to be larger. For a butt welding joint made of structural carbon steel A516 grade 70 with 16 mm thickness, it is necessary to weld 4 passes with the heat-input respectively for the minimum residual stress and deformation are q1=2252 J/mm, q2=2828 J/mm, q3=2458 J/mm, and q4=2878 J/mm. The post-weld heat treatment immediately after welding at 595 oC for 40 minutes will reduce residual stress 3.45 times, reduce longitudinal deformation 2.82 times, reduce transverse deformation 1.54 times, and reduce the angular deformation 1.32 times.
Renewable energy-based electrical microgrid of cold ironing energy supply for berthed ships
Authors: ŞENOL Yunus Emre , SEYHAN Alper
Published: October 2023

The importance of ports, which are the gateways between maritime transport and other modes of transport, is growing every day. In addition, the amount of cargo that ports can handle is increasing rapidly every year. At the same time, the need for energy is increasing. Ships hoteling at ports account for a large portion of the power demand at ports. Today, ships hoteling at ports meet their energy needs with their own auxiliary engines running on fossil fuels. In order to achieve decarbonization and zero emissions targets, it is essential to minimize the use of fossil fuels in ports and to increase the use of renewable energy. In this context, meeting the ship's power needs in port through a renewable energy-based microgrid will help reduce emissions. In this study, after determining the energy needs, the scenarios developed with the HOMER program were used to design electrically and economically suitable microgrid systems and to meet the electricity needs of the ships in port using renewable energy.
Pemimpin Perempuan dalam Sejarah Yogyakarta Hadiningrat dan Relevansinya terhadap UUK DIY
Authors: Al Wafi Abdul Rohim , Rahtikawati Yayan , Nurmila Nina
Published: October 2023

Indonesia is a democratic country with a unitary state system and uses a republic form. This has been stated in Indonesia's main constitution, namely the 1945 Constitution. As a consequence of using the above system, Indonesia has several regions under it which have their own autonomy. One of the autonomy that exists in Indonesia is the special status attached to the province of Yogyakarta. The privileges of Yogyakarta have long been legitimized by related laws, namely Law Number 2 of 1948. Apart from that, the privileges of Yogyakarta have also been strengthened by institutionalizing the form of the Sultanate and standardizing the highest regulations for the area; paugeran, into national regulations, namely Law No. 13 of 2012. So this research focuses on the extent to which paugeran is accommodated by Law no. 13 of 2012, specifically on the aspect of female leaders. This research is an analytic normative research using two theoretical approaches, namely stipulative theory and genealogical theory. It was found that Law no. 13 of 2012 was unable to fully accommodate the paugeran owned by the Sultanate of Yogyakarta. This is evidenced by the existence of several nomenclatures that are not in line with paugeran. In fact, paugeran is the spirit and spirit of the formation of Law no. 13 of 2012
Tangis Bundo Kanduang: Sub-Altern Perempuan Minang dalam Tradisi Bajapuik di Pariaman
Authors: Juliandi Budi , Reza Fadil Muhammad
Published: October 2023

The Bajapuik tradition describes the ongoing process of patriarchal ideological hegemony in social relations, in which the interests of the male community as a superior class are hidden, and the social rights of women as members of society are suppressed. This is a portrait of the process of gender discrimination. In the case of the bajapuik tradition, no matter how high the achievements of women and no matter The bajapuik tradition describes the ongoing process of patriarchal ideological hegemony in social relations, in which hidden the interests of the male community as a superior class, there is a suppression of women's social rights as members of society. This is a portrait of the occurrence of the process of gender discrimination. In the case of bajapuik tradition, no matter how high the achievements of women and how high the intellectual qualities of women still cannot raise their social status on par with men. This article wants to know how the struggle between customary tradition and Islamic law occurred in the Bajapuik tradition in Pariangan. Through qualitative research, it was concluded that   the debate between adat and sharia in Minangkabau, adat always emerged as the main winner, especially in terms of bajapuik marriage. Sharia principles that emphasize women's rights are often left behind by customary domination. In the name of respect for custom, the bajapuik tradition increasingly provides greater benefits to the male side.how high the intellectual quality of women still cannot elevate their social status to equal with men
Bunga Bank dalam Pandangan Nahdlatul Ulama dan Muhamadiyah serta Implikasinya terhadap Undang Undang Perbankan
Authors: Supriyatin  , Kaimudin Kaimudin , Misno Misno
Published: October 2023

Nahdlatul Ulama (NU) is an organization that combines traditionalism and accommodationism with the concept of "Aswaja" as its main way of thinking. NU uses three methods (qawliy, ilhaqiy, and manhajiy) in answering legal problems. On the other hand, Muhammadiyah is an organization that emphasizes tajdid (renewal) and ijtihad in the understanding of Islam, using the methods of ijtihad bayaniy, ijtihad qiyasiy, and ijtihad al-istislahiy.  This research uses literature methods and legal approaches with primary data sources in the form of fatwas of NU, Muhammadiyyah, and banking laws, as well as secondary sources in the form of books, journals, and documents related to the research theme. This article concludes that there are different methods of determining the law on bank interest, NU uses the ilhaqi method, while Muhammadiyah uses qiyas. These differences give birth to the dynamics of legal determination due to differences in methodology. The decision of NU  and  Muhammadiyah despite various polarizations (points of similarity and difference) in the process of determining bank interest law. Thesefatwas, directly or indirectly, through the MUI ultimately have implications for Law No. 7 of 1992 concerning Banking