bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-Optimized Curcuma as Adjuvant Therapy of Osteoarthritis and Its Influence on Gene Regulation (Sirt1), Metabolic Inflammation and Associated Symptoms
Authors: Bianchi Sara , Salamone Maurizio , Vanheule Greet , Den Driessche Mieke Van , Vignale Ilaria , Vignale Luigi
Published: July 2021

Background and aim: Osteoarthritis (OA) is a chronic degenerative disease characterized by an inflammatory state and significant oxidative stress. As curcuma is known for its anti-inflammatory and antioxidant activities, it could be used as alternative therapy next to or together with the standard treatment. This treatment consists of analgesics, steroids or non-steroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation related symptoms. The current study investigates the effect of bio-optimized curcuma on genetic (SIRT1) and metabolic regulation of inflammation and associated symptomatology in patients with osteoarthritis. Materials and methods: In the in vitro study, Hela human cells were seeded in 12-well plates, incubated with curcuma at different concentrations and incubated for 3, 6 and 24 hours. The targeted protein expression/phosphorylation was evaluated by immunoblotting, while cytotoxicity tests were performed by CellTiter-Blue Cell Viability Assay. In the in vivo study, a total of 33 patients were recruited and divided into 3 subgroups based on the treatment: standard treatment (ST), ST + curcuma and ST + curcuma + Vitamin D (2000UI). The health status (SF36) and osteoarthritis index (WOMAC score) were analyzed at 0; 1,5 and 3 months with blood sampling at 0 and 3 months for the evaluation of inflammation markers, 25 (OH) VitD and SIRT1. Results: in vitro data showed no statistically significant decrease (p>0.05) in the number of viable cells. The expression of SIRT1 and the activation of AMP activated protein kinase (AMPK) were significantly increased in all experimental groups compared with the control group (p<0.001). A significant increase in 25(OH) VitD values in the ST + curcuma + VitD group (p <0.007) and in SIRT1 in all groups taking curcuma (p <0.001) was shown. Also for IL-1 (p=0.031), IL-6 (p=0.031) and IFN-γ (p=0.013), all groups taking curcuma showed significantly lower inflammatory markers with no added value of vitamin D. Conclusions: Curcuma as an adjuvant to ST leads to a positive modulation of the SIRT1 pathway, a significant decline of blood inflammatory markers and a better osteoarthritis outcome.
The tachinid Macquartia plumbea Richter & Wood new for the European part of Russia (Diptera: Tachinidae)
Authors: Richter V.A. , Wood D.M.
Published: July 2021

Macquartia plumbea Richter & Wood is for the first time recorded from the European part of Russia (Vaigach Island).
Silence Sits in Places
Authors: Reginato Federico
Published: July 2021

Having become interested in the uprising of the Hirak movement and its denouncement of a 'cancer epidemic' in the Moroccan Rif, I ended up having what appeared to be a shattered experience, one broken by refusals to speak, miscommunication and bureaucratic barriers. Upon returning home, the very same silence that had surrounded my fieldwork then emerged as a resourceful tool with which to make sense of an opaque history. In this article, I will therefore consider silence as a social object that we encounter during fieldwork, as a positional issue and as an epistemological space. In this sense, engaging with what appears to be at the margin of everyday speech requires consideration of silence as something that is made powerful precisely by its being left unsaid.
Some aspects of improving criminal liability for domestic violence against children
Authors: Vlad Kateryna
Published: July 2021

There is the search for optimal ways to improve domestic legislation in terms of criminal liability for domestic violence against children. It has been established that all persons who are victims of domestic violence are under the same criminal legal protection, as the responsibility for domestic violence against them is provided in a single criminal law with a single punishment. There are cases in court practice where a person guilty of domestic violence against an adult family member has received a more severe punishment than domestic violence against a child. However, a situation where a domestic abuser of a child receives a milder punishment than an adult abuser is not fully in line with the principle of the fairness of criminal law. The author has stated that the social danger of domestic violence against children, especially minors, is much higher than violence against adults, as it has a negative impact on the formation of personality, in particular, generates new generations of domestic abusers. As an adult, a child who is abused at home is more likely to be prone to such violence or to commit any other crime related to violence. The author has concluded that it is expedient to consider the issue of establishing increased criminal liability for domestic violence against minors, compared to adults. For this purpose, it is possible to ammend Article 126-1 of the Criminal Code of Ukraine with a qualified type of domestic violence – domestic vio-lence committed against a minor child.
Typical investigative situations during the investigation of mass riots
Authors: Lisnyak Anton
Published: July 2021

The article highlights the features of the investigation of mass riots. Typical investigative situations during their investigation and the most expedient algorithms of actions of police officers for faster investigation of a criminal offense have been considered. The author has emphasized that a typical investigative situation is a set of circumstances to be proved in criminal proceedings on a crime, other circumstances that have arisen in the course of inves-?igative actions, officially and informally established, perhaps even in conjunction with the escalation of contradictions between participants, sub ' objects of forensic activity and other persons. The author maintains that taking into account the typical and individual in the investigation of each specific criminal proceeding makes this process more effective. The role and significance of investigative situations are primarily due to the fact that they are a model for clarifying the unknown elements of a particular situation; their separation and consideration allows during practical activities to save time to determine the feasibility of certain measures in the investigation of crimes. In the typical initial investigative situations of certain types of crimes developed by criminologists, data are concentrated that allow to develop scientific recommendations for the most effective promotion of general and individual versions in the course of investigative activities. Therefore, the typification of the initial investigative situations is an extremely important task that will contribute to the development of effective methods for investigating riots, as well as effective practical activities for the investigation of crimes of this kind. The author has noted that in the investigation of mass riots, the amount of evidence that can be seized during the effective conduct of investigative (search) actions and other measures is quite significant. The initial investigative situation includes a number of stages, the passage of which means its solution. Each of them has its own tasks and ways to solve them. Based on the analysis of a number of scholars’opinions and materials of criminal proceedings, the author identified typical investigative situations of the initial stage of the investigation of mass riots.
Thí nghiệm đánh giá khả năng giảm sóng của cấu kiện bê tông rỗng
Authors: Trung Lê Hải , Tuấn Nguyễn Văn , Tùng Trần Thanh , Linh Đặng Thị , Duy Nguyễn Trường , Dương Bạch
Published: July 2021

Bê tông rỗng là bê tông có cấu trúc rỗng thông nhau được tạo lên từ các cấp phối hạt cốt liệu gián đoạn. Ở một số nước, vật liệu này đã được áp dụng cho các công trình bảo vệ bờ biển do khả năng hấp thụ năng lượng sóng theo cơ chế chủ động. Bài báo này trình bày nghiên cứu khả năng sử dụng bê tông rỗng phục vụ xây dựng đê chắn sóng ngầm – một dạng công trình bảo vệ bờ biển được đánh giá là phù hợp đối với điều kiện Việt Nam. Thí nghiệm mô hình vật lý được thực hiện trên các mẫu cấu kiện bê tông rỗng có dạng hình hộp, được chế tạo với các kích thước đá (5-10, 10-20 và 20-40 mm) và độ rỗng khác nhau (15-25%). Kết quả đo đạc cho thấy chiều cao sóng giảm từ 21% đến 56% khi đi qua đê ngầm dạng thành đứng xếp bằng các mẫu cấu kiện.
Thiết kế tối ưu dầm thép tổ hợp chữ I trong kết cấu cầu liên hợp nhịp đơn giản theo TCVN 11823:2017
Authors: Hùng Trương Việt , Hùng Hà Mạnh , Thuật Đinh Văn , Phúc Hoàng Văn
Published: July 2021

Bài báo trình bày bài toán thiết kế tối ưu cho dầm thép tổ hợp dạng chữ I trong kết cấu cầu liên hợp nhịp đơn giản dựa theo các quy định trong TCVN 11823:2017. Hàm mục tiêu được sử dụng là tối thiểu hóa khối lượng của dầm thép và điều kiện ràng buộc gồm các quy định về cấu tạo, khả năng chịu lực, ứng suất và biến dạng được quy định trong TCVN 11823:2017. Biến thiết kế bao gồm các kích thước tiết diện của dầm thép tổ hợp chữ I. Để giải bài toán tối ưu được đề xuất, thuật toán tiến hóa vi phân được sử dụng. Bài toán đề xuất được đánh giá thông qua việc phân tích tối ưu dầm thép chữ I trong kết cấu cầu liên hợp đơn giản nhịp 33 m và 50 m. Kết quả tính toán cho thấy chương trình được xây dựng bảo đảm được độ chính xác. Bên cạnh đó, việc áp dụng thuật toán tối ưu trong thiết kế cho phép tiết kiệm chỉ còn khoảng 65% đến 75% khối lượng dầm thép được thiết kế theo kinh nghiệm.
Nghiên cứu thực nghiệm đánh giá khả năng sử dụng cát nghiền nguồn gốc đá vôi cho cột BTCT chịu nén
Authors: Dũng Lê Việt , Kiên Tống Tôn , Thành Đỗ Trọng , Lâm Nguyễn Bá
Published: July 2021

Trong bài báo này, việc sử dụng cát nghiền nhân tạo nguồn gốc đá vôi được nghiên cứu thay thế cát tự nhiên trong sản xuất bê tông cấp độ bền chịu nén B20. Với mục đích đánh giá khả năng thích ứng của bê tông sử dụng cát nghiền nhân tạo với hệ thống tiêu chuẩn thiết kế kết cấu BTCT của Việt Nam, nghiên cứu thực nghiệm được phân tích dựa trên các thí nghiệm bao gồm: (i) nén mẫu lập phương xác định cường độ chịu nén, (ii) nén mẫu trụ xác định mô đun đàn hồi, (iii) kéo tuột (Pull-out test) xác định lực dính cốt thép-bê tông, (iv) nén mẫu cột kích thước 20 × 20 × 100 cm đến phá hoại. Kết quả nghiên cứu bước đầu cho thấy sự mất ổn định về cường độ chịu nén của bê tông sử dụng cát nghiền nhân tạo ở hai mức độ: (i) mức độ đạt cường độ nén mẫu và (ii) mức độ giảm mạnh cường độ nén của bê tông khi chuyển từ mẫu nén lập phương 15 × 15 × 15 cm sang mẫu cấu kiện cột BTCT chịu nén kích thước 20 × 20 × 100 cm.
Độ võng dài hạn của kết cấu dầm bê tông cốt thép khi xét tới sự già hóa bê tông
Authors: Hùng Nguyễn Mạnh , Hiếu Nguyễn Trung
Published: July 2021

Sự làm việc dài hạn của kết cấu dầm bê tông cốt thép (BTCT) liên quan trực tiếp đến hai thành phần biến dạng dài hạn của bê tông là biến dạng từ biến, biến dạng co ngót. Bên cạnh các đặc trưng về biến dạng dài hạn thì sự già hóa của bê tông cũng là một đặc trưng khi bê tông làm việc lâu dài trên kết cấu công trình. Sự già hóa của bê tông được đặc trưng bởi hệ số già. Nội dung bài báo trình bày tính toán độ võng dài hạn của dầm BTCT khi xét đến ảnh hưởng của sự già hóa của bê tông với hai nội dung chính: (1) xây dựng mối quan hệ giữa hệ số từ biến và hệ số già dựa trên đề xuất của Bazant cho bê tông có các cấp cường độ nén khác nhau; (2) tính toán độ võng dài hạn có xét đến sự già hóa dựa trên mô hình Mô đun đàn hồi hiệu quả có điều chỉnh (AEMM). Các kết quả tính toán sẽ được so sánh với kết quả thực nghiệm, từ đó sẽ cho thấy rõ mức độ ảnh hưởng khi không xét và có xét tới sự già hóa của bê tông đến độ võng dài hạn của dầm.
Xử lý một số trường hợp đặc biệt trong phân tích hiệu quả tài chính dự án đầu tư xây dựng bất động sản kinh doanh
Authors: Tấn Trần Văn
Published: July 2021

Các dự án đầu tư xây dựng bất động sản kinh doanh có những đặc thù riêng, chịu nhiều ảnh hưởng từ những quy định của pháp luật nên việc lập và phân tích dự án rất phức tạp, đòi hỏi người lập và thẩm định dự án phải hiểu biết và xử lý đúng bản chất kinh tế, phù hợp với quy định của pháp luật. Bài viết này tập trung vào việc xử lý một số vấn đề phức tạp trong phân tích hiệu quả tài chính dự án đầu tư xây dựng bất động sản kinh doanh cho hai trường hợp đang xảy ra phổ biến ở Việt Nam: 1) trường hợp dự án đầu tư xây dựng văn phòng để kinh doanh cho thuê một phần và giữ lại một phần làm văn phòng làm việc của chủ đầu tư; 2) trường hợp dự án đầu tư xây dựng tổ hợp nhà ở, văn phòng làm việc và trung tâm thương mại trong đó có phần căn hộ chung cư bán. Bài viết chỉ ra những bất cập trong việc xác định dòng tiền, xác định lãi suất chiết khấu, phân tích lãi lỗ khi phân tích các loại dự án này và đề xuất giải pháp khắc phục. Phạm vi nghiên cứu là đầu tư kinh doanh bất động sản ở Việt Nam, dựa trên hệ thống pháp luật của Việt Nam. Để giải quyết vấn đề tác giả đã sử dụng các phương pháp nghiên cứu lý thuyết gồm sưu tầm tài liệu, sách, báo; phân tích; suy luận logic; tổng hợp vấn đề và kế thừa các nghiên cứu đã có.
Giám sát tiến độ và khối lượng thực tế bằng mô hình 3D trên dữ liệu đám mây thông qua nền tảng Autodesk Forge
Authors: Sơn Phạm Vũ Hồng , Bảo Nguyễn Đình
Published: July 2021

Trong quản lý dự án xây dựng, tiến độ và chi phí luôn thay đổi hàng ngày do chịu sự chi phối bởi nhiều khía cạnh thực tế từ công trường. Điều này có thể ảnh hưởng đến tổng thời gian hoàn thành và tổng ngân sách của dự án. Nghiên cứu này đề xuất một tiện ích mở rộng (ONSK18) tích hợp trực tiếp trong phần mềm Autodesk Revit, nền tảng Autodesk Forge và kết hợp cùng phương pháp Giá trị đạt được (Earned Value Method - EVM) để theo dõi tiến độ và chi phí của dự án xây dựng. Đồng thời còn tạo được cổng kết nối giữa các bên tham gia dự án bằng cách chia sẽ mô hình 3D bao gồm thông tin tiến độ và khối lượng thực tế của dự án một cách trực quan, cụ thể nhất. Mô hình đề xuất được đánh giá trên một dự án thi công kết cấu của một nhà phố ở đường Lạc Long Quân, Quận 11, TP. Hồ Chí Minh. Kết quả so sánh với thực tế chứng tỏ tính hợp lý và khả năng đưa ra dự đoán chính xác của mô hình.
Nghiên cứu xây dựng bản đồ hiểm họa lũ lụt sử dụng vết lũ lịch sử và mô hình độ cao số
Authors: Chinh Lưu Thị Diệu , Nam Dương Đình , Lai Trịnh Đình , Quỳnh Bùi Duy
Published: July 2021

Gần đây các phương pháp trí tuệ nhân tạo được phát triển, mang đến tiềm năng mới cho việc lập bản đồ vùng ngập lũ sử dụng phương pháp tiếp cận địa hình dựa trên mô hình độ cao số. Nghiên cứu này đề xuất phương pháp xây dựng bản đồ hiểm họa lũ lụt bao gồm vùng ngập lũ và chiều sâu ngập lũ, sử dụng dữ liệu vết lũ lịch sử và mô hình độ cao số. Khu vực nghiên cứu được chọn là tỉnh Quảng Nam và các trận lũ lịch sử năm 2007, 2009 và 2013. Dữ liệu vết lũ lịch sử bao gồm mã số vết lũ, tọa độ vết lũ, địa điểm gắn vết lũ, và chiều sâu ngập lũ. Mô hình độ cao số có độ phân giải cao với kích thước ô lưới 10 m × 10 m. Các kỹ thuật phân tích không gian được áp dụng để phân tích, chồng xếp dữ liệu và thiết lập mối quan hệ không gian của các thuộc tính. Kết quả của nghiên cứu là bản đồ chiều sâu ngập lũ có thể cung cấp các thông tin hữu ích cho các bên liên quan về quản lý thiên tai tại địa phương.
Đánh giá rủi ro cho các dự án giao thông đô thị tại Hà Nội
Authors: Toản Nguyễn Quốc , Thúy Nguyễn Thị
Published: July 2021

Giai đoạn từ năm 2020 đến năm 2030, Hà Nội tập trung triển khai các dự án giao thông đô thị trên toàn thành phố. Rủi ro ngày càng gia tăng cho các dự án giao thông đô thị tại Hà Nội buộc các nhà quản lý phải chú ý hơn tới vấn đề quản lý rủi ro. Bài viết này sẽ phân tích, đánh giá rủi ro cho các dự án giao thông đô thị tại Hà Nội. Dựa trên kết quả một cuộc điều tra khảo sát trên 3 nhóm chủ thể chính tham gia dự án (chủ đầu tư/ban quản lý dự án; đơn vị tư vấn, nhà thầu), tác giả chuyển rủi ro lên khả năng xuất hiện - mức độ tác động phân vùng rủi ro theo mức độ nguy hiểm. Kết quả thu được sẽ giúp các nhà quản lý có nhìn nhận rõ hơn về mức độ nguy hiểm của rủi ro, từ đó lựa chọn được giải pháp đối phó phù hợp với từng rủi ro.
Áp dụng phương pháp dòng tiền xác suất trong phân tích tài chính dự án đầu tư khi xét đến yếu tố bất định
Authors: Anh Nguyễn Tuấn
Published: July 2021

Hiện nay, khi phân tích tài chính dự án đầu tư xét đến các yếu tố bất định và rủi ro, các phương pháp truyền thống, như phân tích độ nhạy, phân tích kịch bản, cây quyết định và mô phỏng Monte Carlo, được sử dụng phổ biến. Tuy nhiên, các phương pháp nêu trên, phần nhiều dựa trên tính toán tất định (Deterministic calculation), đều thể hiện những nhược điểm khiến việc áp dụng có những hạn chế nhất định. Bài báo này, trước tiên, phân tích các ưu nhược điểm điển hình của các phương pháp phổ biến này, sau đó, giới thiệu nội dung của phương pháp dòng tiền xác suất (Probabilistic cash flow approach). Bài báo áp dụng phương pháp nghiên cứu lý thuyết, bao gồm tổng hợp và kế thừa nghiên cứu đã có từ sách, bài báo khoa học; kết với so sánh, phân tích (định tính và định lượng) và suy luận logic. Qua phân tích chi tiết cách thức áp dụng của phương pháp dòng tiền xác suất kết hợp với ví dụ minh họa khi tính toán giá trị hiện tại hiệu số thu chi NPV của dự án, bài báo thể hiện đây là phương pháp mang lại kết quả trực quan, yêu cầu không quá phức tạp về kiến thức toán học trong phân tích rủi ro, và thể hiện sự phù hợp trong việc áp dụng khi phân tích tài chính dự án xét đến các yếu tố bất định.
ARSIP DIGITAL DI KECAMATAN RUMBAI PESISIR
Authors: Muchtar Yuhelmi , Walhidayat  , Rismayeti
Published: July 2021

Pengabdian ini dilakukan atas dasar bahwa penulis tergerak setelah melakukan survey ke Kantor Kecamatan Rumbai Pesisir, Penulis melihat masih belum terkelolanya arsip dengan baik dan juga sistem pengarsipan yang belum sesuai dengan standar. Dalam praktik pengelolaan arsip berbasis kertas, banyak permasalahan yang dihadapi, sehingga memberikan ruang pada media elektronik sebagai alternatif dalam pengelolaan arsip. Dalam terminologi kearsipan, media elektronik dikelompokan sebagai arsip media baru. Salah satu bentuk penyimpanan arsip media baru adalah media digital. Media digital biasanya memerlukan alat bantu berupa komputer, karena tidak dapat dibaca secara langsung. Arsip yang disimpan dalam bentuk digital dapat berupa gambar, suara, video, tulisan atau lainnya yang dapat dijadikan sebuah data dalam bentuk biner (binary), dapat diolah dalam program komputer dan disimpan dalam media penyimpanan data digital. Mudah-mudahan dengan adanya pengabdian ini akan menambah ketrampilan mereka dalam hal mendigitalisasikan Arsip dan penggelolaan Arsip dan sistem pengarsipan yang baik sehingga dapat meningkatkan pelayanan Publik. Pengabdian ini akan dilaksanakan untuk Staff di Kecamatan Rumbai Pesisir. Untuk mencapai target luaran kegiatan ini, maka metode yang dilakukan adalah pelatihan kepada mitra. Pelatihan yang diberikan adalah teknik tata cara mendigitalkan Arsip, pengelolaan dan pemberian motivasi untuk bisa memengelola Arsip dengan baik. Rancangan PKM : (1) Sebelum diberikan materi pelatihan peserta diberikan selembar kuesioner untuk melihat kemampuan dan pengetahuan peserta tentang Arsip Digital setelah itu peserta diajak untuk memahami pentingnya pelatihan ini sebagai bekal dalam meningkatkan ketrampilan dan (2) peserta diajak untuk praktik dengan dipandu oleh seorang instruktur yang sudah berpengalaman. (3) Pada tahap terakhir, setelah peserta memiliki ketrampilan dalam mendigitalkan Arsip dan mengelola kearsipan serta bagaimana tata cara penyusunan arsip difilling Kabinet   selanjutnya mereka diberikan selembar kuesioner, dari hasil olahan kuesioner dapat dilihat bahwa kemampuan staf meningkat secara signifikan sebesar 64,62%, kemudian dari jumlah peserta yang ditargetkan 10 orang ternyata yang ikut 13 orang, ini menunjukkan bahwa pelatihan ini memang sangat diperlukan staf dalam pekerjaan sehari hari.

Arsip Digital, Sistem, Manajemen, Arsip, Kecamatan Rumbai Pesisir
PEMANFAATAN INTERNET PADA SMARTPHONE DALAM MENDUKUNG KEGIATAN BISNIS ONLINE DI LINGKUNGAN ARISAN RT
Authors: Hafi Hafsah  , Zulafwan  , Willyansah
Published: July 2021

Pengabdian kepada masyarakat yang dilakukan dan ditulisakan dalam artikel ini terkait dengan pemanfaatan teknologi informasi dan komunikasi melalui penggunaan internet pada smartphone oleh ibu-ibu anggota arisan di lingkungan Rukun Tetangga 01, Perumahan Delima Puri. Pekanbaru, Riau. Kegiatan ini dilakukan melalui seminar dengan menyampaikan materi terkait pemanfaatan internet dalam mendukung jual beli online dan sekaligus untuk mengenalkan istilah umum bahasa inggris pada jual beli online.  Tulisan ini bersifat deskriftif yang dimaksudkan untuk memperoleh informasi pemahaman dan permasalahan ibu –ibu anggota arisan terkait materi yang diangkat dalam seminar.  Pada era modern saat ini, teknologi informasi dan komunikasi (TIK) memiliki peran yang sangat penting dalam meningkatkan dan mengembangkan perekonomian masyarakat, khususnya dengan pemberdayaan perempuan yaitu dalam hal ini ibu-ibu anggota arisan.  Kegiatan ini juga dimaksudkan untuk berbagi ilmu tentang pemanfaatan internet melalui pemanfaatan smartphone guna mendukung kegiatan usaha online dan mengenalkan istilah-istilah Bahasa Inggris yang umum digunakan dalam hal jual beli online melalui internet. Selain hal tersebut di atas, seminar ini dapat mengisi kegiatan arisan ibu-ibu RT disamping kegiatan pertemuan rutin yang mereka lakukan, yang diharapkan dapat meningkatkan pemahaman mereka dalam hal pemanfaatan internet. Secara umum, ibu-ibu tersebut tidak mengalami kendala yang cukup berarti terkait pemahaman materi yang diberikan.  Namun pada ibu-ibu anggota yang usianya di atas 50 tahun, penggunaan internet lebih kepada alat untuk berkomunikasi saja.  Sementara itu, jenis platform terbanyak yang digunakan dalam beberapa usaha online yang  mereka lakukan adalah aplikasi WhatsApp.
Имитационная модель оценки артефактов немоноэнергетичности и рассеяния в компьютерной томографии
Authors: Осипов С.П. , Мирзоев Х.Д. , Чахлов С.В. , Осипов О.С. , Усачев Е.Ю.
Published: July 2021

A simulation model for estimating the beam-hardening and scattering in computed tomography in the geometry of a parallel beam is proposed on the example of inhomogeneous objects with axial symmetry. The modeling algorithm consists of a block of formation of projections and a block of reconstruction of images of object cross sections based on the Abel reverse transformation. The developed algorithm is implemented as a MathCad program. The efficiency of the algorithm and program is demonstrated by the example of a multilayer ball. Estimates of the beam hardening artifacts and scattering of the simulation model are compared with experimental estimates for the radial distributions of the linear attenuation coefficient.
Visitor Management of Dieng Cultural Festival and Millennial Tourist Satisfaction
Authors:   Universitas Pancasila, Puspita Nungky , Gunadi I Made Adhi ,   Universitas Pancasila, Virananda Vinca Bunga ,   Universitas Pancasila
Published: July 2021

Purpose: This study aimed to analyze how the management of Dieng Culture Festival attract visitors and examine the influence of Dieng Culture Festival to the millennial tourists’ satisfaction. Research methods: The methodology of this study referred to descriptive quantitative research methods. Questionnaire was used to collect the data to be analyzed using multiple linear regression analysis. Results and discussions: Satisfaction of millennial tourist can be derived from 42.6% of hard measure and soft measure variable, while the remaining 57.4% of millennial tourists’ satisfaction variables can be derived by other variables not examined in this study. Conclusion: The hypothesis test results proved that the visitor management of the Dieng Culture Festival, which use hard measure and soft measure has a significant and positive effect on millennial tourists satisfaction.
The Effect of Job Satisfaction on Turnover Intention of Food and Beverage Service Employees at Alila Seminyak Bali
Authors:   Hotel Administration Program, Politeknik Pariwisata Bali, Indonesia, Mulyawan I Gusti Gede Anggareksa Putra , Suprastayasa I Gusti Ngurah Agung ,   Travel Business Management, Politeknik Pariwisata Bali, Indonesia, Witarsana I Gusti Agung Gde ,   Hotel Administration Program, Politeknik Pariwisata Bali, Indonesia, Kartini Luh Putu ,   Applied Tourism Master Program, Politeknik Pariwisata Bali, Indonesia
Published: July 2021

Purpose: This study aims to examine the effect of job satisfaction on turnover intention of food and beverage service employees and to investigate possible areas of improvement to establish job satisfaction on overcoming turnover intention. Research methods: The job satisfaction is measured with a simplified JDI Model, and the turnover intention is measured with Mobley et al.’s Turnover Intention Heuristic Model. The research used quantitative and qualitative methods with a questionnaire and semi-structured interview as the instrument. The analysis includes a correlation test, the classic assumption test, and a simple linear regression test. Results and discussions: The result shows that job satisfaction has a significant negative effect on employee turnover intention. The ability of job satisfaction variables to explain the variance of turnover intention variable was moderate. Demographic factors such as age and academic education are among the most significant factors to influence turnover intention. Three areas of improvement to establish job satisfaction on overcoming turnover intention were addressed.
The Tax Optimization Strategy Of Tourism Sector To Increase Banyuwangi Regency’s Income
Authors:   State Polytechnic of Banyuwangi, Mukti Masetya Mukti , Wijaya Jemi Cahya Adi ,   State Polytechnic of Banyuwangi, Febrian Ayu Wanda ,   State Polytechnic of Banyuwangi
Published: July 2021

Purpose: Banyuwangi Regency is intensively optimizing the tourism sector that has enormous natural and cultural potential. The tourism sector has a broad impact (multiplier effect) felt by all layers of businesses, including businesses in the entertainment industry, hospitality and restaurants. These three business sectors will directly affect income through the tourism sector's local tax. The purpose of this study is determine the relationship of the tourist visitation number to the entertainment tax of Banyuwangi Regency, to find out the relationship of the tourist visitation number to the hotel tax of Banyuwangi Regency, to determine the relationship of the tourist visitation number to the restaurant tax of Banyuwangi Regency. Research methods: The analytical method used in this study is Product Moment Correlation Analysis. Results and discussions: The results of this study indicate that the relationship of the Tourist visitation Number (X1) to the Entertainment Tax (Y1) obtained by Pearson product moment value is 0.938 (Very Strong). The relationship of the Tourist visitation Number (X1) to the Hotel Tax (Y2) obtained by Pearson product moment value is 0.955 (Very Strong). The relationship of the Tourist visitation Number (X1) to Restaurant Tax (Y3) obtained by Pearson product moment value from the Correlation Coefficient is 0.889 (Very Strong). Conclusion: The Three tourism taxes had positive correlations with the Tourist visitation
Needs Analysis of Natural, Cultural, and Arts Tourism Potency
Authors:   English Language Education, Universitas Slamet Riyadi, Indonesia, Hakim Luqman Al , Supeni Siti ,   Civics Education, Universitas Slamet Riyadi, Indonesia, Aji Leticia Juliena ,   English Language Education, Universitas Slamet Riyadi, Indonesia, Rinugroho Attharik Bowi ,   English Language Education, Universitas Slamet Riyadi, Indonesia, Sulistiawan Sulistiawan ,   English Language Education, Universitas Slamet Riyadi, Indonesia, Arfianto Yanu ,   English Language Education, Universitas Slamet Riyadi, Indonesia
Published: July 2021

Purpose: the study aims at analyzing the needs of natural, cultural, and arts tourism destination at Plesungan Tourism Village, Gondangrejo, Karanganyar. There are four objects being observed and analyzed before doing community service. Research methods: the type of research is descriptive study. The subjects of research are the head of four tourism objects at Plesungan Village. They are Plesungan Waterpark, Meteor Putih Hermitage, Lemah Putih Hermitage, and Waste Management Tool. The methods in collecting the data are an interview, observation, and documentation. The data were analyzed through data display, data reduction, and conclusion. Results and discussions: the findings of research are the needs of promotion to improve the quantity of visitors, there is a necessity of serving local food and beverages as well as preserving local heritage, there are no souvenirs from the village that empower local potency, the necessity of healthy life training during the pandemic, and the English skill of the villagers need to be improved to facilitate foreign tourists while visiting the village. Conclusion: empowering local potency to facilitate tourists is the main needs of the village to preserve and improve the quality of tourism service and the quantity of visitors.
DSS for best e-commerce selection using AHP-WASPAS and AHP-MOORA methods
Authors:   STIMIK STIKOM Indonesia, Mahendra Gede Surya
Published: July 2021

eIQ Consumer Pulse 2019 determines the 6 largest e-commerce in Indonesia, namely Blibli, Bukalapak, JD.id, Lazada Indonesia, Shopee and Tokopedia. This is due to an increase in e-commerce transactions. The COVID-19 pandemic, which emphasizes social distancing and physical distancing, has also played a role in increasing these transactions. Indonesia is also predicted to become the market leader in Southeast Asia due to this. On the other hand, each e-commerce customer has their preferences in choosing e-commerce to use in transactions. Various criteria make customers confused due to intense competition between e-commerce companies. DSS is a solution in choosing the right e-commerce for each customer's preferences. The AHP-WASPAS and AHP-MOORA methods can be used in calculations for determining favorite e-commerce in Indonesia. The CRISP-DM framework also helps in preparing the research flow well. 3 decision-makers are used to provide weighting criteria using AHP. The results of this study indicate that the Tokopedia alternative is the best e-commerce, with a preference value of 0.8964 for AHP-WASPAS and 0.4245 for AHP-MOORA. The second and third places are Bukalapak and Lazada, respectively. The weighting of the criteria by the decision-maker, the alternative normalization process and the calculation technique for the preference value have a significant impact on the ranking results.
Comparative analysis of support vector machine and k-nearest neighbors with a pyramidal histogram of the gradient for sign language detection
Authors:   Universitas Teknologi Yogyakarta, Imantoko Imantoko , Hermawan Arief ,   Universitas Teknologi Yogyakarta, Avianto Donny ,   Universitas Teknologi Yogyakarta
Published: July 2021

The communication method using sign language is very efficient considering that the speed of information delivery is closer to verbal communication (speaking) compared to writing or typing. Because of this, sign language is often used by people who are deaf, speech impaired, and normal people to communicate. To make sign language translation easier, a system is needed to translate symbols formed from hand movements (in the form of images) into text or sound. This study aims to compare performance such as accuracy and computation time of Support Vector Machine (SVM) and K-Nearest Neighbors (KNN) with Pyramidal Histogram of Gradient (PHOG) for feature extraction, to know which one is better at recognizing sign language. Yield, both combined methods PHOG-SVM and PHOG-KNN can recognize images from hand movements that form certain symbols. The system built using the SVM classification produces the highest accuracy of 82% at PHOG level 3, while the system built with the KNN classification produces the highest accuracy of 78% at PHOG level 2. The total computation time of the fastest training and testing by the SVM model is 236.53 seconds at PHOG level 3, while the KNN model is 78.27 seconds at PHOG level 3. In terms of accuracy, PHOG-SVM is better, but in terms of computation time, PHOG-KNN takes the place.
IMPLEMENTATION OF RELIGIOUS MODERATION EDUCATION FOR SANTRI AT THE MIFTAHUL ULUM SUREN ISLAMIC BOARDING SCHOOL KALISAT JEMBER EAST JAVA
Authors: Bosra Mustari , Umiarso Umiarso
Published: July 2021

Today's religious moderation is an interesting topic in the interaction and relations of modern society. The emergence of a group or individual actions that are intolerant and disrespectful of other people or groups in physical or verbal treatment is a serious problem in religious moderation. This study aims to explain and describe the implementation of religious moderation education in Islamic boarding school Miftahul Ulum Suren Jember which has a positive influence in forming a safe, dynamic, and conducive community structure. The type of this research was qualitative with a phenomenological approach. The participants in this study were 7 people including clerics and students who meet the predetermined research criteria. Data were collected through interviews and observations using interview and observation instruments. The data analysis technique used in this research was the reduction, presentation, and interpretation of the data. The study’s findings showed that in the implementation of religious moderation education at the Miftahul Ulum Islamic boarding school, there are two important themes which are the concept of religious moderation education and the obstacles and supports in its application. The value of mutual respect and tolerance is the main concept that is taught. Group fanaticism and culturing of figures are negative values that need to be eliminated in religious moderation education. Constraints and obstacles in applying religious moderation education in Islamic boarding schools include the regeneration of Kiai who have equal knowledge to continue the existence of the pesantren. The implication of this religious moderation education has a positive impact in constructing the society’s knowledge and culture. This research still has many limitations both in terms of themes and studies and research implementation techniques. In the future, further research can enrich and strengthen the results of this previous research.
Assessment of left ventricular contractility in acute inferior wall myocardial infarction by speckle tracking echocardiography
Authors:   Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation, Akramova E.G. ,   Medical Wing of the Kazan Federal University, Kazan, Russian Federation, Vlasova Е.V. ,   Medical Wing of the Kazan Federal University, Kazan, Russian Federation
Published: July 2021

Aim: to assess the results of speckle tracking echocardiography (STE) in patients of working age with acute inferior wall myocardial infarction (MI) in the early period after coronary stenting. Patients and Methods: STE was performed using EPIQ-7 Ultrasound Machine (Philips, USA) in 55 patients with acute inferior wall MI one week after percutaneous coronary intervention and 29 healthy individuals of working age. Patients with acute inferior wall MI were divided into two subgroups, i.e., with (n=45) or without (n=10) areas of local contractile impairment (dyskinesia, akinesia, hypokinesia). Results: the most common cause of MI was the occlusion of the right coronary artery (82.4% in subgroup 1 and 60% in subgroup 2) in multivascular involvement (84.4% and 90%. respectively). In patients with local contractile impairment, reduced left ventricular ejection fraction (EF) was reported in 28.9%, global longitudinal strain in 86.7%, and global circular strain in 76.7%. Meanwhile, in patients without local contractile impairment, left ventricular ejection fraction (LV EF) was within normal ranges, global longitudinal strain was reported in 100% and global circumferential strain in 70%. The presence and severity of local dysfunction did not affect the reduction in segmental strain (median varied from -9% to -15%). In inferior wall MI, the abnormal regional longitudinal strain of 6 LV segments (basal and mid inferoseptal, inferior, and inferolateral) was reported in both hypokinesia and normokinesia. Conclusions: ultrasound evaluation of systolic LV function using STE is characterized by greater diagnostic value compared to the measurement of EF only and objectifies the efficacy of surgery. Quantitative assessment of the recovery of both global and local systolic contractility is another advantage of STE allowing for personalized treatment. KEYWORDS: inferior wall myocardial infarction, echocardiography, speckle tracking technology, percutaneous coronary intervention, ejection fraction. FOR CITATION: Akramova E.G., Vlasova Е.V. Assessment of left ventricular contractility in acute inferior wall myocardial infarction by speckle tracking echocardiography. Russian Medical Inquiry. 2021;5(4):169–175 (in Russ.). DOI: 10.32364/2587-6821-2021-5-4-169-175.
Measurement of blood pressure using automatic monitors in patients with atrial fibrillation: a comparative analysis
Authors:   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Vertkin A.L. , Sycheva A.S. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Kebina A.L. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Sergeeva E.A. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Malyavina M.A. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
Published: July 2021

Aim: to specify indications for use of distinct types of blood pressure monitors (mechanical, automatic with arrhythmia detector and upper arm cuff, and automatic with arrhythmia detector and wrist cuff) in patients with atrial fibrillation (AFib). Patients and Methods: 202 patients (mean age 61.8 ± 1.3 years) with paroxysmal AFib of any origin occurred no more than 1 month ago and atrial tachysystole were enrolled. All patients had a history of hypertension of various severity. This study was conducted in three units, i.e., ICU, ED, and therapeutic department. Blood pressure (BP) measurements were performed at 8 a.m., 12 p.m., and 4 p.m. using various types of BP monitors in turn, i.e., mechanical BP monitor (whose readings were considered reference values), automatic BP monitor OMRON M2 BASIC HEM-7121-ALRU (OMRON M2 BASIC) with upper arm cuff, automatic BP monitor OMRON RS2 HEM-6121-Ru (OMRON RS2) with wrist cuff, and automatic BP monitors of other manufacturers with upper arm cuff (B1 and A1) or wrist cuff (B2 and A2). Results: in patients with AFib of any severity, BP readings measured by automatic BP monitors OMRON M2 BASIC and OMRON RS2 demonstrate no significant differences compared to BP readings measured by mechanical BP monitor. Meanwhile, BP readings measured by BP monitors of other manufacturers (A1, A2, B1, and B2) were significantly different from reference values. The more severe was arrhythmia, the more significant the differences were. Conclusions: automatic BP monitors OMRON M2 BASIC and OMRON RS2 that provide as accurate as possible BP readings can be recommended for measuring BP in patients with AFib of any severity in ED, outpatient wards, and at home (self-control). KEYWORDS: hypertension, atrial fibrillation, blood pressure measurement, blood pressure variability, blood pressure monitor. FOR CITATION: Vertkin A.L., Sycheva A.S., Kebina A.L. et al. Measurement of blood pressure using automatic monitors in patients with atrial fibrillation: a comparative analysis. Russian Medical Inquiry. 2021;5(4):189–195 (in Russ.). DOI: 10.32364/2587-6821-2021-5-4-189-195.
Clinical efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation in real-world clinical practice
Authors:   Kursk Regional Clinical Hospital, Kursk, Russian Federation, Khruslov M.V. , Sorokina A.S. ,   Kursk Regional Clinical Hospital, Kursk, Russian Federation, Sapel'nikova Yu.A. ,   Kursk State Medical University, Kursk, Russian Federation, Vavilova T.V. ,   V.A. Almazov National Medical Research Center, St. Petersburg, Russian Federation
Published: July 2021

Aim: to assess the efficacy and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AFib) in real-world clinical practice. Patients and Methods: this non-interventional prospective study enrolled 356 patients aged 50-75 years with AFib and creatinine clearance ≥50 ml/min. All patients were divided into three age-matched groups based on DOACs prescribed. Group 1 patients (n=120) received rivaroxaban 20 mg daily. Group 2 patients (n=112) received dabigatran etexilate 150 mg twice daily. Group 3 patients (n=124) received apixaban 5 mg twice daily. The groups were comparable in comorbidities and the risks of thrombotic and hemorrhagic complications. Followup was 2 years after starting treatment. Thrombotic complications, massive bleedings, and death for any reason were considered end-points. Results: no significant differences in the rate of cardiogenic thrombotic complications between the groups were reported. In patients who received apixaban, fewer bleeding complications were diagnosed (insignificant differences). Conclusions: the efficacy and safety of DOACs in patients over 50 years are similar. KEYWORDS: atrial fibrillation, oral anticoagulants, thrombotic complications, infarction, stroke, bleedings. FOR CITATION: Khruslov M.V., Sorokina A.S., Sapel'nikova Yu.A., Vavilova T.V. Clinical efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation in real-world clinical practice. Russian Medical Inquiry. 2021;5(4):196–199 (in Russ.). DOI: 10.32364/2587-6821-2021-5-4-196-199.
Resynchronization therapy in end-stage heart failure
Authors:   M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation, Shumakov D.V. , Zybin D.I. ,   M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation, Popov M.A. ,   M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation, Dontsov V.V. ,   M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation, Agafonov E.G. ,   M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
Published: July 2021

Heart failure (HF) is a common condition, and its overall prevalence is constantly growing. HF ultimately progresses to end-stage disease that is refractory to optimal medical therapy and requires implantable devices or heart transplant. In recent years, cardiac resynchronization therapy (CRT) has been generally accepted in patients with NYHA class III or IV, reduced left ventricular ejection fraction (less than 35%), and the wide QRS complex (>120 msec). CRT improves the efficacy of heart ventricle function and, as a result, physical performance and quality of life. Reverse cardiac remodeling occurs at a pathophysiological level that improves systolic function. Patients with end-stage HF who are on the heart transplant list are a specific group in whom CRT is considered a “bridge” to surgery. This review paper discusses state-of-the-art, advances, and unresolved issues in this area. KEYWORDS: cardiac resynchronization therapy, heart failure, left ventricular remodeling, ejection fraction, heart transplant. FOR CITATION: Shumakov D.V., Zybin D.I., Popov M.A. et al. Resynchronization therapy in end-stage heart failure. Russian Medical Inquiry. 2021;5(4):206–211 (in Russ.). DOI: 10.32364/2587-6821-2021-5-4-206-211.
Conservative treatment for intermittent claudication
Authors:   L.L. Levshin Institute of Cluster Oncology of the I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kuznetsov M.R. ,   S.S. Yudin City Clinical Hospital, Moscow, Russian Federation, Reshetov I.V. ,   L.L. Levshin Institute of Cluster Oncology of the I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Sapelkin S.V. ,   A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russian Federation, Yasnopol’skaya N.V. ,   S.S. Yudin City Clinical Hospital, Moscow, Russian Federation
Published: July 2021

This paper discusses the issues emerging during the treatment of lower-limb arterial diseases and intermittent claudication. According to the international and Russian guidelines, the common management strategy for intermittent claudication is as follows: conservative treatment is recommended in patients without limiting intermittent claudication who can walk 30 m or more without pain. Drugs that are prescribed is these patients are addressed. No large well-designed studies on most of these drugs were conducted, therefore, it is challenging to assess their efficacy in patients with intermittent claudication. The authors focus on cilostazol that has the largest evidence base. This drug is included in the Russian and international clinical guidelines. Several students demonstrate that cilostazol provides antithrombotic effect, stabilizes atherosclerotic plaques, prevents hyperplasia of neointima and restenosis after vascular procedures, improves lipid metabolism, and significantly increases pain-free walking distance (intermittent claudication distance). Recent studies show that cilostazol can be used in the complex treatment for COVID-19 due to pleiotropic mechanism of action. KEYWORDS: lower-limb arterial diseases, intermittent claudication, conservative treatment, cilostazol, COVID-19, restenosis, antiplatelet therapy. FOR CITATION: Kuznetsov M.R., Reshetov I.V., Sapelkin S.V., Yasnopol’skaya N.V. Conservative treatment for intermittent claudication. Russian Medical Inquiry. 2021;5(4):212–217 (in Russ.). DOI: 10.32364/2587-6821-2021-5-4-212-217.
Rehabilitation Interventions for Gait Problems in Patients With Diabetic Peripheral Neuropathy: A Scoping Review
Authors:   Department of Occupational Therapy, Semnan University of Medical Science, Semnan, Iran., Hassani Zahra , Mokhtarinia Hamid Reza ,   Department of Ergonomics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Gabel Charles Philip ,   Independent Research, Access Physiotherpay Coolum Beach Qld Australia.
Published: July 2021

Background and Objectives: Gait and balance disturbances are challenging conditions in patients with Diabetic Peripheral Neuropathy (DPN). The overall literary consensus is that rehabilitation interventions are effective in improving gait performance in this patient group. This review sought to highlight and assess the literature and provide a scoping review on the current knowledge gaps in the rehabilitation interventions for the gait problems of patients with DPN. Methods: An electronic databases search was done between 2001 and May 2020. Besides, a hand-search method was used for grey literature. Two experts reviewed the results and screened them based on the subject’s diagnosis with DPN and gait problems. Results: Of 87 studies obtained, nine met the inclusion criteria. The frequent components of the rehabilitation interventions included exercise therapy, dual-task intervention, and the use of assistive devices. The outcomes utilized most frequently included changes in balance and stability, muscle strength, proprioception, function, and gait parameters. Conclusion: Evidence was formed as a scoping review to guide rehabilitation for DPN patients with gait problems. Rigorous comparative studies with clearly defined interventions are needed.