bluuebunny/crossref_metadata_2025 huggingface dataset:
Infrastruktur Jalan dan Kriminalitas di Pedesaan Indonesia
Authors:   Program Studi Magister Perencanaan Ekonomi dan Kebijakan Pembangunan, Fakultas Ekonomi dan Bisnis, Universitas Indonesia, Vidyaras Winda , Vidyaras Winda ,   Program Studi Magister Perencanaan Ekonomi dan Kebijakan Pembangunan, Fakultas Ekonomi dan Bisnis, Universitas Indonesia
Published: July 2023

Penelitian ini melihat bagaimana infrastruktur jalan mempengaruhi kriminalitas di pedesaan Indonesia. Sejak dikeluarkannya Undang-Undang No. 6 Tahun 2014 tentang Desa, terjadi pembangunan masif infrastruktur jalan untuk mengembangkan perekonomian desa. Namun, pembangunan jalan tersebut menimbulkan adanya eksternalitas negatif, yaitu kriminalitas. Dengan model regresi logistik, penelitian ini menganalisis data Potensi Desa tahun 2006-2018 di seluruh Indonesia. Hasil menunjukkan bahwa pembangunan infrastruktur jalan di pedesaan umumnya beriringan dengan peningkatan peluang kriminalitas sekitar 1,3-1,5 kali lebih tinggi. Setelah pembangunan masif, terindikasi peningkatan ekonomi yang berdampak pada turunnya kriminalitas di desa-desa terpencil. Temuan ini mendukung literatur infastruktur jalan dan aksesibilitas dapat memberikan peluang terjadinya kriminalitas.
DESAIN RAK TEMPAT PENYIMPANAN TABUNG GAS ARGON DENGAN KAPASITAS MAKSIMUM 3 TON
Authors: Basori  , Marsudi  , Aldi Hari Tri Sakti Ridwan
Published: July 2023

Gas tungsten arc welding (GTAW) uses argon gas as a protective gas in the welding process. Argon gas cylinders weigh 100 kg, making it difficult to mobilize in large quantities when the welding work is at a certain height. Therefore it is necessary to create a storage area that is able to accommodate and withstand the load of gas cylinders and their contents and can be mobilized at a certain height. In order to get a suitable storage area, a design has been carried out, which includes calculating the strength of the frame, determining the material and design of the lifting lug, and calculating the welding connection of the lifting lug and hollow steel. The rack material used is SS400 type, the compressive stress that occurs due to the force acting on the hollow iron is 91.124 MPa and the stress received by the base plate is 127.5 MPa, while the allowable compressive stress for the material is 152 MPa. The load received by the lifting lug is 33,866.6 N, and the tensile stress due to the force acting on the lifting lug is 76.88 MPa, while the allowable tensile stress is 152 MPa, so the lifting lug is declared safe to use.
On certain topical issues of development of preventive activities of centers of public health and medical prevention
Authors:   The Federal State Budget Scientific Institution “The N.A. Semashko National Research Institute of Public Health” of the Ministry, Nechaev V.S. , Zagoruychenko A. A. ,   The Federal State Budget Scientific Institution “The N.A. Semashko National Research Institute of Public Health” of the Ministry
Published: July 2023

In actual conditions, increasing of health risks for population determines actuality of exploration of organization of preventive activities of centers of public health and medical prevention. Objective: to analyze particular actual issues of development of preventive activity of centers of public health and medical prevention in Russia. Material and methods. The topical selection of publications, analytical method, comparative analysis and systemic approach were applied. Results. The key measures required for effective preventive activity in centers of public health and medical prevention were established and aggregated. Within the framework of task of active involvement of population into unified preventive environment the implementation of new health care mobile technologies into activities of medical personnel of centers of public health and medical prevention is claimed to monitor patients with the purpose of treatment of various chronic non-communicable diseases and elimination of risk factors of their development. Conclusion. The provision of medical and preventive services to population on a free-of-charge basis is among advantages of preventive activities of centers of public health and medical prevention. The development of unified preventive environment in centers of public health and medical prevention applying mobile health care technologies permits to increase interest of population in health self-control and conscious implementation of medical recommendations about healthy life-style. The implementation of marketing measures can promote increasing of organizational and reputation status of “health center” among population.
Soft-technologies in medical rehabilitation after reconstruction of the anterior cruciate ligament of the knee joint
Authors:   Branch of the S. M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation in Moscow, Prikhodko A.N. , Suin P.A. ,   Polyclinic of FSBI «12 Consultative and Diagnostic Center» of the Ministry of Defense of the Russian Federation, Nayda D.A. ,   FSBI «Main Military Clinical Hospital named after Academician N. N. Burdenko» of the Ministry of Defense of the Russian Federation, Prikhodko N.A. ,   MIREA – Russian Technological University
Published: July 2023

The use of soft-technologies in medical rehabilitation is a highly relevant and promising direction of the remote method of restoring the health of patients. The authors have developed a program for an electronic computer «Medical rehabilitation (therapeutic gymnastics after reconstruction of the anterior cruciate ligament of the knee joint)». It is designed for patients to independently perform a set of exercises of therapeutic gymnastics at home. Based on the results of the lesson, the patient fills out a report, on the basis of which the attending physician makes adjustments to the individual medical rehabilitation plan. The analysis of the results of the approbation based on an anonymous survey indicates high patient satisfaction when using a mobile application and an increase in commitment to the implementation of recommendations
Sponging of five tumour suppressor miRNAs by lncRNA-KCNQ1OT1 activates BMPR1A/BMPR1B-ACVR2A/ACVR2B signalling and promotes chemoresistance to hepatocellular carcinoma
Authors: Banerjee Soma , Majumdar Swagata , Chakraborty Anannya , Das Sumit , Gorain Mahadeo , Chatterjee Soumyabrata , Dey Indrashish , Bhowmik Sayantani , Ghosh Suchandrima , Banerjee Sanjana , Ahammed Sk , Chowdhury Abhijit , Datta Simanti , Kundu Gopal C
Published: July 2023

Diverse mechanisms have been established to understand chemoresistance of hepatocellular carcinoma (HCC), but the contribution of non-coding RNAs are not surveyed well. We aimed here to explore the lncRNA/miRNA axis in hepatitis C and B virus infected HCC to investigate the mechanism of chemoresistance and to classify a potential therapeutic target for HCC. The small RNA transcriptome, and qRT-PCR validation with the liver tissues of both HCV and HBV infected HCC patients revealed that miR-424-5p/miR-136-3p/miR-139-5p/miR-223-3p/miR-375-3p were the most downregulated five miRNAs in HCC compared to normal (log2fold change ≤-1.5, Padj≤0.05).In-silicopathway analysis with the validated targets of each miRNA depicted that the signalling pathways regulating pluripotency of stem cells commonly targeted by the all five miRNAs. Subsequent validation by 3’UTR-luciferase assays and western blot analysis disclosed that these five miRNAs impeded either same or diverse genes, but all from BMP signaling pathways including BMPR1A/BMPR1B by miR-139-5p, miR-136-5p & miR-375-3p and ACVR2A/ACVR2B by miR424-5p & miR223-3p. Furthermore, restoration of each miRNA in Huh7/SNU449 cells inhibited phosphorylation of downstream SMAD1/5 and ERK1/2, and attenuated EMT/stemness/sphere formation/chemoresistance/invasion/migration of cells. To investigate the mechanism of suppression of these miRNAs, “DIANA” prediction tool was employed and lncRNA-KCNQ1OT1 was retrieved as interacting partner of all five miRNAs. Ago2-RNA-immuno-precipitation/in vitro RNA pull-down assays revealed that lncRNA-KCNQ1OT1 physically interacted and sequestered all the five miRNAs in the cytoplasm. Hence, KCNQ1OT1 was deleted in Huh7/SNU449 cells using CRISPR-technology and observed regression of oncogenic properties with enhanced chemosensitivity and reduced metastasis of cells. Shrinkage of tumor size/volume in NOD-SCID mice injected with KCNQ1OT1-K/O cells further strengthened our observations. Thus, lncRNA-KCNQ1OT1 is the main regulator, which reduces the level of beneficiary miRNAs in the tumor milieu and modulates BMP signaling to promote chemoresistance to HCC suggesting lncRNA-KCNQ1OT1 might have robust potential to be a therapeutic target for HCC.
Co-application of humic acid, potassium dihydrogen phosphate and melatonin (osmo-regulators) ameliorate the effects of drought stress in Barley (Hordeum vulgare L.)
Authors: Zafar Fizza , Noreen Zahra , Shah Anis Ali , Usman Sheeraz
Published: July 2023

Purpose
Drought has an adverse impact on the production and growth of cereals globally. Due to drought stress, cereals’ cultivation declined day by day, worldwide. Hence, ultimate yield does not fulfill the required demand. The current research investigated the consequences of drought stress on morpho-physiological, yield and biochemical parameters of barley plants and a comparison of different osmo-regulators and their ameliorating capacity towards drought stress.
Methods
A pot trial was held in a completely randomized (CR) design with three replicates manner to investigate the role of humic acid, potassium dihydrogen phosphate and melatonin (osmo-regulators) synergistic application in ameliorating drought stress. Three barely varieties (Haider-93, Sultan-17 and Jau-17) were selected for this experiment. The treatments applied were as follows; humic acid (400 ppm), potassium dihydrogen phosphate (20 ppm) and melatonin (0.5 mM) with two water levels i.e., Control (normal watering) and drought stress (stop watering).
Results
Results indicated that foliar application of all osmo-regulators improved propagation, antioxidants, proteins, chlorophyll, mineral contents and productivity parameters, while alleviate Malondialdehyde content, hydrogen peroxide and relative membrane permeability value studied under drought stress and non-drought stress. The maximum yield was noticed in Jau-17 plants given humic acid in control and drought stress in Jau-17. The order of effectiveness of osmo-regulators in this study was humic acid > melatonin > potassium dihydrogen phosphate.
Conclusion
Osmo-regulators examined in this study had potential role in combating against drought stress and could also be effective for various other abiotic stresses.
Blood Transfusion Is Associated with Hepatitis C in the Older Drinking Population: Analysis of the National Health and Nutrition Examination Survey from 2013 to 2018
Authors: Ji Kangkang , Shen Yucheng , Chen Wei , Zhang Leiming , Xu Kangjie , Meng Hai , Li Li , Sun Minli
Published: July 2023

BACKGROUND: Although blood transfusion and hepatitis C might be related, the exact association has not been reported. This study aimed to investigate whether blood transfusion increases the prevalence of hepatitis C infection among the older drinking population.
METHODS: This study included an older population with drinking habits participating in the National Health and Nutrition Examination Survey from 2013 to 2018. We used weighted multivariable logistic regression models to examine the association between hepatitis C and blood transfusion. A nomogram was employed to evaluate the prevalence of hepatitis C in older drinking people. Propensity matching (PSM) was conducted to balance the confounding factors. Logic models following the PSM were used to validate the association between blood transfusion and hepatitis C.
RESULTS: Among the 2972 individuals surveyed, hepatitis C virus (HCV) infection was reported in 6.43% (37/575) of the transfused group and 2.33% (56/2397) of the non-transfused group. The prevalence of HCV infection was significantly higher in the transfused group than in the non-transfused group. Blood transfusion history was associated with hepatitis C (odds ratio 11.430, 95% confidence interval 5.321–24.554) in the weighted multivariable logistic analysis. The association was particularly pronounced in people aged 60–69 years (odds ratio 14.907, 95% confidence interval 6.459–34.405). The nomogram suggested blood transfusion and age as the two major risk factors for HCV infection. Moreover, the results after PSM still showed that blood transfusions increase the risk of HCV infection.
CONCLUSION: Blood transfusion increases the risk of HCV infection in older drinking patients, with a higher risk, particularly in those aged 60–69 years.
The effect of long-term exposure to heated tobacco products on the central nervous system using novel in vivo experimental methods
Authors: Yamada Hidetada , Yamazaki Yu , Takebayashi Yoshiko , Yazawa Kyosuke , Sasanishi Miwako , Motoda Atsuko , Nakamori Masahiro , Morino Hiroyuki , Takahashi Tetsuya , Maruyama Hirofumi
Published: July 2023

Heated tobacco products (HTPs) are new products being promoted by the tobacco industry as having a reduced potential for harm compared with conventional cigarettes. However, there is insufficient information on the health risks of long-term exposure to HTPs on the central nervous system (CNS). To determine the health risks of HTP use, valid and reproducible in vivo protocols must be established. Therefore, we propose a simple experimental method to evaluate the impact of long-term exposure to HTPs on the CNS in an amyloid mouse model. App knock-in mice were exposed to HTPs for 16 weeks, five days per week. Serum cotinine concentration was used to validate the HTP exposure model. Histological analysis indicated that HTPs had minimal effects on amyloid pathology. However, gene ontology analysis was performed on differentially expressed genes in the cerebral cortex that had thresholds of |log2 Fold Change| > 1 and non-adjusted p value < 0.05. The results indicated that exposure to HTPs mainly affected non-inflammatory pathways in the CNS. Further studies are required to determine the safety of HTPs on the CNS. Our experimental method provides a convenient means for evaluating these parameters.
Mitigating Membrane Fouling in Dairy Wastewater Treatment System: Assessing the Effects of Integrated 3DP Turbulence Promoter
Authors: Al-Tayawi Aws N. , Gulyás Nikolett Sz. , Gergely Gréta , Fazekas Ákos Ferenc , Szegedi Balázs , Hodúr Cecilia , Lennert József Richárd , Kertész Szabolcs
Published: July 2023

Dairy factories annually generate increasing amounts of wastewater, which can cause eutrophication due to high concentrations of amino acids and lipids. To address this issue, membrane technology has emerged as a promising solution, but membrane fouling remains a significant challenge, since it can couse decreased flux, lessen membrane rejection performance and increased energy demand. This study aimed to reduce membrane fouling by integrated a Three-Dimensional Printed (3DP) turbulence promoter into an ultrafiltration dead-end cell and varying stirring speeds. Two mathematical models, Hermia and Resistance-in-series, were used to analyze the fouling process. According to both models, the cake layer formation model indicated the most prevalent fouling mechanism. The specific energy demand, permeate flux, membrane rejection, and membrane reversible and irreversible resistances were measured, calculated and compared. The results suggest that the combination of integrated 3DP turbulence promoter and high stirring speeds can effectively reduce membrane fouling in a dairy wastewater treatment module.
Light-driven electron transfer by Quantum vibronic ratcheting
Authors: Fleming Graham , Roy Partha , Widel Zachary , Liu Rui , Valdiviezo Jesús , Zhang Peng , Leonardo Cristina , Mansergh Jarrett , Chowdhury Sutirtha , Beratan David , Therien Michael
Published: July 2023

The optical control of coherence to improve and create a new molecular function is a grand challenge in science. In this work, we present a synthetic strategy to build a donor-donor-acceptor (D1D2A) supramolecular construct and tailor vibronic coherence to leverage an efficient long-range electron-transfer by defeating the thermodynamic energy trap imposed by Boltzmann statistics. The relaxed D1* lies 0.35 eV below the D2* state. By a combined transient IR and two-dimensional electronic vibrational spectroscopy study we show that selective excitation of the vibronic bands of lower energy primary donor (D1) leads to substantial rapid (< 200 fs) formation of a charge-transfer state (D1D2+A−), followed by hole transfer leading to (D1+D2A−). This provides direct evidence of electron transfer (secondary donor D2 to A) induced by a vibronic quantum ratcheted ‘uphill’ energy transfer from D1 to D2. Thus, it lays out a rational for improving efficiency of solar energy conversion and expanding the spectral bandwidth in synthetic light harvesting systems.
Presenteeism among Healthcare Workers in Samarinda and Related Factors – Study Using Stanford Presenteeism Scale 6 (SPS-6) Questionnaire Modified in Indonesian
Authors: Linda Linda , Adi Nuri Purwito , Werdhani Retno Asti , Soemarko Dewi Sumaryani , Friska Dewi
Published: July 2023

Background
Working while sick or also known as presenteeism is a risk factor that can have a negative impact on workers health and productivity. Presenteeism among healthcare workers will also increase the risk of patient safety. However, there is insufficient study on presenteeism in Samarinda. Thus, this study aims to determine the proportion of presenteeism, and factors related to presenteeism among healthcare workers in Samarinda.
Methods
This study used a cross-sectional study design, using primary data collected online during the period of October-November 2022. The sample used was convenience sampling with a minimum of 130 samples. SPSS version 26 was used to carry out binary logistic regression analysis.
Result
A total of 136 respondents completed the questionnaire, with the proportion of presenteeism was 31.6%. The dominant factors related to presenteeism among healthcare workers in Samarinda were stress factor (p = 0.001; aOR = 17.998; CI 95%=3.247–99.762) and work experience < 2 years (p = 0.048; aOR = 2.760; CI 95%=1.011–7.534). Pseudo-R square value was 33.2%.
Conclusion
Compared to other studies, the proportion of presenteeism obtained in this study was lower. Stress factor and work experience < 2 years were the dominant factors related to presenteeism. It is advisable for healthcare management to implement strategies to reduce stressors at the workplace, routine screening to detect stress and increasing job resources. For healthcare workers, it is advisable to increase self resources, nurture positive attitudes and relations with co-workers, and manage stress. Further study needed to explore other factors related to presenteeism.
Knowledge, Attitude, and Practices of Complementary and Alternative Medicine: A Patients' Perspective
Authors: Makarem Nisrine N , Brome Dayana , Sawaf Souad Susan , Sayyid Abdallah , Romani Maya
Published: July 2023

Background: Complementary and alternative medicine (CAM) includes a wide set of domains, including mind-body interventions, herbs and supplements, and alternative medical systems. Although CAM is commonly practiced in Lebanon, it is still not integrated into mainstream medicine. There is a paucity of data regarding patients’ utilization, familiarity, and attitudes toward CAM.
Objectives: The main aim of this study was to assess the knowledge, attitudes, and practices toward CAM among patients.
Material and Methods: A cross-sectional, questionnaire-based survey was conducted among 213 patients attending family medicine clinics at the American University of Beirut Medical Center (AUBMC).
Results: Among the respondents, 78.9% indicated that they had used CAM in the past six months. Thirty-three percent use CAM regularly as daily activity and as a way for health and immunity maintenance. The motive behind using CAM was related to CAM’s accessibility (63.3%), experience with CAM (64.8%), and not its less expensiveness (82%) or failure of traditional medicine (91.3%). Patients were most familiar with relaxation therapy (90.4%), massage (89.6%), meditation (87.3%), herbal medicine (86.5%), naturopathy (85.1%), yoga (81.7%), spiritual healing/ prayer (60.4%) as well as garlic (93.9%) and ginger (93%). Moderately favorable attitudes towards CAM were reflected by the patients as signified by the slightly above-mean average towards CAM permissiveness (M = 3.67, SD = .56). Approximately 90% of participants indicated that their physicians have never asked them about CAM usage, 76.5% indicated that they did not inform their physician about CAM use, and 70.8% indicated they would utilize CAM services if provided at the AUBMC.
Conclusion:The study findings indicate limited familiarity with CAM, high utilization rates, and positive attitudes toward it. This is the first study in Lebanon to assess knowledge, attitudes, and practices of all 5 CAM domains among patients within a healthcare setting in a major academic medical center as a follow-up on a study that assessed the knowledge, practices, and attitudes of physicians and nurses towards CAM at the same institution.
A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis
Authors: Escande Carlos , Cal Karina , Leyva Alejandro , Rodriguez-Duarte Jorge , Ruiz Santiago , Santos Leonardo , Colella Lucía , Ingold Mariana , Vilaseca Cecilia , Galliussi German , Ziegler Lucía , Peclat Thais , Bresque Mariana , Handy Rachel , King Rachel , Reis Larisa Menezes dos , Espasandin Camila , Breining Peter , Dapueto Rosina , Lopez Andres , Thompson Katie , Agorrody Guillermo , DeVallance Evan , Meadows Ethan , Lewis Sara , Barbosa Gabriele Santana , de Souza Leonardo Osbourne Lai , Chichierchio Marina Santos , Valez Valeria , Aicardo Adrian , Contreras Paola , Vendelbo Mikkel , Jakobsen Steen , Kamaid Andres , Porcal Williams , Calliari Aldo , Verdes Jose , Du Jianhai , Wang Yekai , Hollander John , White Thomas , Radi Rafael , Moyna Guillermo , Quijano Celia , O'Doherty Robert , Moraes-Vieira Pedro Manoel , Holloway Graham , Leonardi Roberta , Mori Marcelo , Camacho-Pereira Juliana , Kelley Eric , Duran Rosario , Lopez Gloria , Batthyany Carlos , Chini Eduardo
Published: July 2023

Obesity-related type II diabetes (diabesity) has increased global morbidity and mortality dramatically. Previously, the ancient drug salicylate demonstrated promise for the treatment of type II diabetes, but its clinical use was precluded due to high dose requirements. In this study, we present a nitroalkene derivative of salicylate, 5-(2-nitroethenyl)salicylic acid (SANA), a molecule with unprecedented beneficial effects in diet-induced obesity (DIO). SANA reduces DIO, liver steatosis and insulin resistance at doses up to 40 times lower than salicylate. Mechanistically, SANA stimulated mitochondrial respiration and increased creatine-dependent energy expenditure in adipose tissue. Indeed, depletion of creatine resulted in the loss of SANA action. Moreover, we found that SANA binds to creatine kinases CKMT1/2, and downregulation CKMT1 interferes with the effect of SANA in vivo. Together, these data demonstrate that SANA is a first-in-class activator of creatine-dependent energy expenditure and thermogenesis in adipose tissue and emerges as a candidate for the treatment of diabesity.
WITHDRAWN: Copper Nanoparticles on expression of LuxS of the genes in Pseudomonas aeruginosa strains anti-Biofilm formation
Authors: Ahmed Mais E. , Mohammed Luma
Published: July 2023

The resistance to broad spectrum antimicrobials therapy such Pseudomonas aeruginosa, . Biofilms are major virulence factors to resist antibiotics; in this concern the need for providing new alternatives for antibiotics is becoming an urgent requirement,Now day therapies and applications based treatments felid nanoparticle. copper Oxide nanoparticles, were produced from MDR and strong biofilm producer P. aeruginosa isolate by biological method, against P. aeruginosa colonization of the biofilm and LuxSgene expression.This study was aimed to explore whether green synthesized copper nanoparticles (CuNPs) can function as an anti-biofilm agent of P. aeruginosa bacteria. The nanoparticles was synthesized from cell free extract of P. aeruginosa. Characterization of biosynthesized copper nanoparticles was carried out to determine the chemical and physical properties of the product usinging AFM, TEM ,XRD and UV visible spectrometry. The hexagonal structure was confirmed by XRD, size range was marked 13-19nm by TEM, was used to confirm the surface morphology. AFM analysis used to reveal the roughness and distribution of nanoparticles. UV–visible spectra of the synthesized nanoparticles recorded maximum peak at 300 nm. Copper nanoparticles showed remarkable biofilm inhibitory on multidrug resistant at (32 μg/ml) sub Minimum Inhibitory Concentration (MIC), CuNPs exhibited remarkable effect against P. aeruginosa .Strong biofilm producer strains were incubated with 1ml of sub MIC of CuNPs for 24 -48 hrs at 37C . The current study has proven that copper oxide nanoparticles possess the ability to act as anti-biofilm agents against P. aeruginosa. This was evidenced by their significant downregulation of LuxS gene expression, The results indicated a major down-regulation in LuxS expression after exposure to CuNPs, suggesting the antimicrobial agent against multidrug-resistant P. aeruginosa infections.
Bio mediated synthesis of ZnS @ ZnO nanocomposite from Cucumis melo pulp and chicken feathers: Photodegradation of dyes and antibacterial activities.
Authors: Nandisha P S , . sowbhagya , Pasha M.A , Umesha B , Harshitha M
Published: July 2023

Synthesis of efficient photocatalyst in the form of ZnS @ ZnO nanocomposite from Cucumis melo pulp and waste chicken feather powder as fuel and source of oxygen and sulphur respectively is reported in this work. XRD, SEM, TEM, PL EDS, FT-IR, DRS, and EIS techniques are used to investigate the composite's structural, morphological, optical, and electrochemical properties. The SEM analysis confirmed core-shell nanocomposite formation consisting of nano ZnS as the core encapsulated by the nano ZnO shell. The XRD data of ZnS @ ZnO nanocomposite resembled pure crystalline ZnO and ZnS nanoparticles. The intensity and crystal size of nano ZnO, nano ZnS, and ZnS @ ZnO nanocomposite were calculated using the Debye-Scherrer equation and found to be 29, 24.2, and 71 nm, respectively. DRS confirmed the band gap of the synthesized material, which was calculated using a K-M plot and found to be 3.4 eV, 3.5 eV, and 3.04 eV for ZnO, ZnS nanoparticles, and ZnS @ ZnO composite, respectively. The synthesized ZnO-ZnS nanocomposite showed enhanced photocatalytic activity towards MB [92%], RhB [98.4%], and CR [90.9 %] dyes in water under Visible light. Radicals formation was confirmed by the ESR technique. TOC analysis was done to verify the organic dye degradation. ZnS @ ZnO nanocomposite also exhibited potent antibacterial activity.
Modulatory Effects of Noradrenergic and Serotonergic Signaling Pathway on Neurovascular Coupling
Authors: Tran Cam Ha , Renden Robert , Institoris Adam , Sharma Kushal
Published: July 2023

Dynamic changes in astrocyte Ca2+ are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the critical role of glutamatergic signaling in this process has been extensively investigated, the impact of behavioral state, and the release of behavior-associated neurotransmitters, such as norepinephrine and serotonin, on astrocyte Ca2+ dynamics and functional hyperemia have received less attention. We used two-photon imaging of the barrel cortex in awake mice to examine the role of noradrenergic and serotonergic projections in NVC. We found that both neurotransmitters facilitated sensory-induced increases in astrocyte Ca2+. Interestingly, while ablation of serotonergic neurons reduced sensory-induced functional hyperemia, ablation of noradrenergic neurons caused both attenuation and potentiation of functional hyperemia. Our study demonstrates that norepinephrine and serotonin are involved in modulating sensory-induced astrocyte Ca2+ elevations and identifies their differential effects in regulating functional hyperemia.
Expert System Based Diabetes Diagnoses Using Ensemble Model
Authors: ROY PAPPU CHANDRA , MISHRA SUDHIR KUMAR
Published: July 2023

The title “Expert Systems” was given by John McCarthy, in which he entitled his study as “Applied Science and Technology” of making quick witted devices”. The development of ‘thinking’ computer systems popularly known as “Expert Systems” furthermore; also known as “Synthetic Intelligence” which explains the idea of learning these algorithms so that they can act intelligently. The mindset of software programs is basically to execute their activities intelligently like humans. The designs that allow software programs to work in such a way which frames its society as the ability to act intelligently known as Expert systems. The ability of these systems in order to use relevant connection between database which can be used in primary level screening for various disease, proper medication as well as estimating various results. In today’s growth following approach is being used in all useful domains which are beneficial for the society so that complex issues could be solved on time. This domain was being setup on the increasing demand the central attribute of human – mind can be imitated via these Expert systems.The work executed in this domain depicts how these expert systems could work intelligently provided if the data fed to this system is precisely accurate and tested by cross validation. To carry out this research total fourteen classifiers are being studied out of which we find four algorithms more suitable for this research namely Artificial Neural Network, K-Nearest Neighbor, Support vector machine, Naïve bayes. On top of it, to make our results more accurate and efficient, ensemble technique is used which predicts the output by taking the majority number of votes from the results predicted by these algorithms; in order to make this tool more efficient and accurate. The software tools which are being used are to execute this research are matrix laboratory and weka 3.6.13. After detailing of medical history, we prepared a rich dataset of around 400 people which is taken in the form of questionnaire from different sections of the society on the basis of ten physiological parameters. This enriched data has been tested and validated in terms of accuracy and prediction of correct data. This trained dataset is fed to graphical user interface and is tested so that it can predict correct output on the given input data provided to it.The values which are provided to the interface are five numeric values and rest are nominal values. The fig which illustrates the working of this tool is shown in Fig. 3. The foremost aim of this proposed work is to build an intelligent tool which is capable of predicting accurate results and provide correct data so that it could prove helpful in medical domain and can be used for initial screening of patients at an earlier stage so that proper treatment can be followed by them.Talking about the privacy of these algorithms out of all algorithms ANN outperformed with accuracy of 97.5% and our proposed ensembling technique assured the accuracy of 98%.
Performance Analysis of Rare-earth Doped Oxide Thin-Film Transistors Using Neural Network Method
Authors: Peng Zengyi , Huang Xianglan , Shen Yuanyi , Wu Weijing , Li Min , Xu Miao , Wang Lei , Gu Zhenghui , Yu Zhuliang , Peng Junbiao
Published: July 2023

The work analyzes the key impact factors on the performances of rare-earth element doped oxide thin film transistors (TFTs), which are potentially used for high performance displays, by comparatively using a Bayesian Neural Network (BNN) method and Artificial Neural Network (ANN) method based on published and self-experimental data which was exhaustively collected. Both BNN and ANN methods can effectively identify the primary impact factors among rare-earth element type, doping concentration, thin film thickness, channel length and width, which are key factors to determine the TFTs performances. Comparisons between the ANN and BNN methods, the BNN approach offers more reliable and robust predictions on the dataset. Accordingly, the efficient neural network models tailored to the data features were accurately established. A key outcome from the BNN models is the relative importance ranking of the influence factors and relationship between the carrier mobility and element type, concentration as well. To the TFT mobility, rare-earth element concentration is the most critical factor, suggesting lower concentration exhibited higher mobility, followed by the rare-earth element type. To the sub-threshold swing performance of TFTs, the rare-earth element type is the most significant influence factor, suggesting higher valence rare-earth is superior to lower valence one, followed by the element concentration. The results are basically consistent with experimental tendency. These insights could effectively guide the design of oxide semiconductor materials and TFT device structure, to achieve high-performance (high mobility and high stability) oxide TFT devices for displays.
“Uptake of breast cancer screening services among undergraduate female students in the oldest University of Tanzania: a cross-sectional study”
Authors: Mally Mary , Tesha Novatus , Anaeli Amani
Published: July 2023

Background
Worldwide breast cancer is the leading cause of cancer-related death among women. Breast cancer mortality can be reduced by early detection and prevention. Despite the existence of breast cancer screening methods, uptake of breast cancer screening is still very low partly due to a lack of awareness of the risk factors for breast cancer and poor knowledge of the screening services. This study was set to assess uptake of breast cancer screening service among undergraduate female students in Dar es Salaam.
Methods
This was an analytical cross-sectional study which conducted among 434 undergraduate female students using self-administered questionnaires in July 2022. Data were analyzed using Stata Version 15 and presented using descriptive and inferential statistics.
Results
The results of this study show that those who have ever been screened for breast cancer were 37 (9.23%), and 40% of the participants have heard about breast cancer screening methods. The most common screening method practiced by study participants was breast self-examination (48.65%). The knowledge of the participants regarding risk factors for breast cancer was generally low; only 40% of the participants had good knowledge of the breast cancer risk factors.
Conclusion
The uptake of breast cancer screening service in the studied area was generally low, as majority of the participants were not aware of screening methods for early detection of breast cancer.
PIT tagging does not measurably reduce reproductive success in sensitive burrow-nesting seabirds
Authors: Marcouillier Léo , Miranda Eliane , Whelan Shannon , Fifield Dave , Hatch Scott , Shoji Akiko , Nakajima Chinatsu , Elliott Kyle
Published: July 2023

Investigator disturbance while monitoring seabirds often results in lower survival rates and breeding success, leaving lasting negative impacts on the population and biased observations. Puffins, in particular, are more sensitive to investigator disturbance than many other seabirds, and researchers must seek to decrease their disturbance and time spent at puffin colonies. Radio-Frequency Identification (RFID) via Passive Integrated Transponder (PIT) tags is an inexpensive and reliable way to identify individuals when coupled with automated RFID detectors, potentially avoiding the need for recapture for nocturnal seabirds. PIT tags either can be implanted subcutaneously or attached externally to leg bands, but it is unclear which method causes lower disturbance. To examine the impact of PIT tagging on rhinoceros auklets (Cerorhinca monocerata; a member of the puffin clade) nesting in artificial burrows on Middleton Island, Alaska, during the 2022 breeding season, we monitored burrow entrances with automated recording RFID readers to collect presence and nest attendance data. PIT tagged and control birds had similar breeding success and chick growth rates. Birds tagged externally were detected less often than birds marked with a subcutaneous implant. We conclude that PIT tagging on the rhinoceros auklet is a relatively non-invasive method for seabird monitoring, and that subcutaneous implants doesn't cause more disturbance than external attachment.
Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia
Authors: Prameswari Hawani , Effendi Cut Azlina , Khalid Achmad , Irianti Setyorini , Fatati Ita , Akbar Mohammad
Published: July 2023

Background: Early onset preeclampsia, defined as preeclampsia that occurs before 34th weeks, has a higher cardiovascular events due to higher cytokine concentrations. Hemodynamic changes in preeclampsia can trigger cardiac remodeling as indicated by increase of soluble-ST2 (sST2). Global longitudinal strain were able to detect systolic dysfunction better than the ejection fraction. This study aims to evaluate the correlation between serum levels of sST2 towards GLS in patients with early-onset preeclampsia.
Methods: This is a cross-sectional observational study with correlation analysis. Subjects were patients with severe preeclampsia with gestational age before 34 weeks at Dr. Hasan Sadikin Bandung and Bandung Kiwari Regional General Hospital from June to August 2022. Examination of sST2 was carried out through blood samples using the ELISA method. sST2 was measured using Presage ST2 Assay reagent. GLS examination was carried out using speckle tracking technique with EchoPAC. Correlation analysis was conducted using the Pearson test if normally distributed, otherwise Spearman's correlation was conducted. Correlation analysis was followed by linear regression.
Results: A total of 30 patients met the inclusion criteria. The mean age was 30.83 ± 7.09, with 17 (56.7%) multiparous patients. The median sST2 was 145.75 ng/mL, and the median GLS was -17.4%. Spearman correlation analysis showed that there was a significant negative correlation with moderate strength between sST2 and GLS (r=0.583; p<0.002). Linear regression showed that every 1 ng/ml increase in sST2 would give a decrease in GLS of 0.014%.
Conclusion: There is a significant correlation between sST2 and GLS in patients with early onset severe preeclampsia.
Presence of Coronary Artery Disease in Adults with Newly Detected Diabetes Mellitus
Authors: Lai Cheng-Chien , Chang Betty Chia-Chen , Hwang Lee-Ching
Published: July 2023

Purpose
We aimed to analyze the presence and extent of coronary artery disease in patients with newly detected diabetes mellitus.
Methods
Clinical health examinations of asymptomatic community-dwelling adults between 2008 and 2018 at a medical center in Taiwan were reviewed. Coronary computed tomography angiography was performed in 444 participants, of which 338, 54, and 52 were categorized as ‘without diabetes mellitus’, ‘newly detected diabetes mellitus’, and ‘known diabetes mellitus’, respectively.
Results
Prevalence of significant coronary artery disease (≥ 50% stenosis) was higher in participants with newly detected diabetes mellitus than participants without diabetes mellitus (40.7% vs 20.1%, p < 0.0001). Among those with coronary artery stenosis, the number of coronary vessels with significant obstruction (0.72 vs 0.42, p = 0.0147) was also higher in participants with newly detected diabetes mellitus. Using multiple logistic regression analysis, new detection of diabetes mellitus was identified as an independent risk factor for significant coronary artery disease (odds ratio: 2.153, 95% confidence interval: 1.112–4.166).
Conclusion
Asymptomatic patients with newly detected diabetes mellitus had higher prevalence and greater extent of coronary artery disease than those without diabetes mellitus. More attention should thus be paid to the assessment of coronary artery disease in patients with newly detected diabetes mellitus.
Solution synthesis and enhanced photocatalytic activity of layered ZnO and MoS 2 hybrid nanostructure
Authors: Liu Lili , Chen Ping , zhang xin , Kovarik Libor , De Yoreo James , Liu Jun , Sushko Maria L.
Published: July 2023

Numerous inorganic materials have been identified as potential candidates for high-performance photocatalysts. However, their solar-to-energy conversion efficiencies still fail to meet commercial requirements. The main hurdle is the rapid recombination of photoexcited electrons and holes in single-phase materials. A viable predicted approach to suppress charge recombination is coupling two materials to form a two-dimensional (2D) heterostructure that physically separates photoinduced electrons and holes in different layers. In this work, the heterostructure-based paradigm was tested and a scalable solution synthesis of epitaxial ZnO-MoS2 heterostructure was developed. A 2D ZnO-MoS2 heterostructure was synthesized under hydrothermal conditions by stabilizing intermediate Zn-hydroxide states on a functionalized MoS2 surface. Detailed characterization showed the formation of multilayer heterostructure with MoS2 flakes intercalated between large size ZnO plates. The performance of this heterostructure was evaluated using photocatalytic degradation of rhodamine B. A degradation efficiency of 70% was measured within 90 minutes of visible-light irradiation, almost doubling the efficiency of the corresponding single-phase materials or their physical mixtures.
The effect of δ (delta)-catenin on small-world brain network properties in breast cancer patients before chemotherapy
Authors: Xue Mingtuan , Du Wei , Cao Jiajun , Jiang Yuhan , Song Duan , Yu Dan , Zhang Junyi , Guo Junjie , Xie Xuejun , Xie Lizhi , Miao Yanwei
Published: July 2023

Our study is to investigate the effect of δ-catenin on the alterations in small-world brain network before chemotherapy in breast cancer patients by rs-fMRI, based on the hypothesis that different δ-catenin expressions have independent brain imaging characteristics. A total of 105 cases of pathologically confirmed breast cancer were collected and divided into high δ-catenin expression (DH, 52 cases) and low expression (DL, 53 cases) groups. Also, 36 healthy women matched for age were enrolled as a healthy control group (HC). The results show differences in several network topology attributes among the three groups. Furthermore, in addition to differences in nodal efficiency, betweenness and degree centrality metrics between the patient group and HC in multiple brain regions, there were also alterations between the DL and DH groups in brain regions such as the supramarginal and inferior frontal gyrus, which supports our hypothesis. Neuropsychological scores also showed that the DL group had significantly shorter short and long-term memory times than the DH group. The study concluded that different states of δ-catenin had significantly different effects on the attributes of the breast cancer patients' brain network and had characteristic impacts on some brain regions. They could also be involved in executive function-related cognitive functions and changes in regulating emotions.
Effect of Epoxy Resin Reinforcement on Screw Withdrawal Strength of Fiberboard and Particleboard Used in the Furniture Industry
Authors: Uysal Mesut , Tasdemir Cagatay , Memis Dogan
Published: July 2023

The authors have requested that this preprint be removed from Research Square.
Solar Pre-drying Study of Sorption Isotherms of Saharan Fish
Authors: Larbi Ahmed Amine , Mediani Ahmed , Djaber Abdelkarim , Cherif Tigani , Naima Ouled Amar , Zahra Klimani
Published: July 2023

The objective of this study is to determine the desorption isotherms of Saharan fish in order to predict the ideal conditions for solar drying and storage. The experiments were conducted at different temperatures using the gravimetric-static method, with a defined range of water activity. The results reveal that the desorption isotherms of Saharan fish behave in accordance with type II, as per the BET classification. Specifically, the equilibrium moisture content decreases with increasing temperature for each level of water activity, and a clear hysteresis effect is observed. Four mathematical models were applied to fit the experimental data, and it was found that the GAB model accurately represents the desorption isotherms of Saharan fish. Important parameters such as the isosteric heat of sorption and the shelf life of the product were deduced from these isotherms. The physicochemical analysis of our Saharan fish provides detailed information on their composition and properties, while the microbiological analysis of fresh and dried fish reveals the presence of various microorganisms, with varying microbial load. These results offer vital information for the industry, thereby contributing to the improvement of quality management, shelf life, and production of Saharan fish products.
Manual-assisted pressure reduction versus pressure reduction alone for intussusception in pediatric patients: a case-control study
Authors: Gou Zehui , Xie Xiaolong , Zheng Qianwen , Liu Juxian
Published: July 2023

Purpose: The aim of this present study was to compare the effectiveness of combined manual-assisted reduction and pneumatic/hydrostatic reduction versus pneumatic/hydrostatic reduction alone in treating pediatric patients with intussusception.
Methods: Children suffered from intussusception who were treated by pneumatic/hydrostatic reduction with or without manual assistance between January 2019 and January 2021 were retrospectively analyzed. According to the method of reduction, the patients were grouped as MPH group (combination of pneumatic/hydrostatic reduction and manual assistance) and PH group (the pneumatic/hydrostatic reduction alone). The data collected included the demographic information, clinical symptoms, abdominal signs, investigations, success rate of reduction and details of failure cases.
Results: A total of 751 children were finally included in the analysis, including 380 patients in the PH group and 371 patients in the MPH group. There were no significant differences in baseline characteristics between the PH group and the MPH group. The time of radiation exposure time and reduction in PH group (155.53±30.34 s, 267.71±40.17 s, respectively) were significantly higher than those in MPH group (112.67±30.29 s, 222.69±53.18 s, respectively) (p <0.001). While the success rate of reduction in MPH group (363 cases, 97.84%) was significantly higher than that in PH group (361 cases, 95.00%) (p =0.036). There were no statistical differences in perforation rate and recurrence rate between the two groups.
Conclusion: Pneumatic/hydrostatic reduction combined manual assistance can increase the success rate of reduction, decrease the time of radiation exposure and and will not increase the incidence of complications, which is worth promoting in clinical practice.