bluuebunny/crossref_metadata_2025 huggingface dataset:
Pole dynamics and an integral of motion for multiple SLE(0)
Authors: Alberts Tom , Byun Sung-Soo , Kang Nam-Gyu , Makarov Nikolai G.
Published: October 2024

We describe the Loewner chains of the real locus of a class of real rational functions whose critical points are on the real line. Our main result is that the poles of the rational function lead to explicit formulas for the dynamical system that governs the driving functions. Our formulas give a simple method for mapping the class of rational functions into solutions to a non-trivial system of quadratic equations, and for directly showing that the curves in the real locus satisfy geometric commutation. These results are entirely self-contained and have no reliance on probabilistic objects, but make use of an integral of motion for the Loewner chain that is motivated by ideas from conformal field theory. We also show that the dynamics of the driving functions are a special case of the Calogero–Moser integrable system, restricted to a particular submanifold of phase space carved out by the Lax matrix. Our approach complements a recent result of Peltola and Wang, who showed that the real locus is the deterministic $$\kappa \rightarrow 0$$

κ
→
0

limit of the multiple SLE$$(\kappa )$$

(
κ
)

curves.
Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes
Authors: Apaolaza Paola S. , Chen Yi-Chun , Grewal Kavi , Lurz Yannik , Boulassel Severin , Verchere C. Bruce , Rodriguez-Calvo Teresa
Published: October 2024

Aims/hypothesis

Islet prohormone-processing enzymes convert peptide hormone precursors to mature hormones. Defective beta cell prohormone processing and the release of incompletely processed peptide hormones are observed prior to the onset of diabetes, yet molecular mechanisms underlying impaired prohormone processing during the development of diabetes remains largely unknown. Previous studies have shown that prohormone convertase 1/3 (PC1/3) protein and mRNA expression levels are reduced in whole islets from donors with type 1 diabetes, although whether PC1/3-mediated prohormone processing in alpha and beta cells is disrupted in type 1 diabetes remained to be explored. Herein, we aimed to analyse the expression of PC1/3 in islets from non-diabetic donors, autoantibody-positive donors and donors diagnosed with type 1 diabetes or type 2 diabetes.

Methods

Immunostaining and high-dimensional image analysis were performed on pancreatic sections from a cross-sectional cohort of 54 donors obtained from the Network for Pancreatic Organ Donors with Diabetes (nPOD) repository, to evaluate PC1/3 expression patterns in islet alpha, beta and delta cells at different stages of diabetes.

Results

Alpha and beta cell morphology were altered in donors with type 1 diabetes, including decreased alpha and beta cell size. As expected, the insulin-positive and PC1/3-positive areas in the islets were both reduced, and this was accompanied by a reduced percentage of PC1/3-positive and insulin-positive/PC1/3-positive cells in islets. PC1/3 and insulin co-localisation was also reduced. The glucagon-positive area, as well as the percentage of glucagon-positive and glucagon-positive/PC1/3-positive cells in islets, was increased. PC1/3 and glucagon co-localisation was also increased in donors with type 1 diabetes. The somatostatin-positive cell area and somatostatin staining intensity were elevated in islets from donors with recent-onset type 1 diabetes.

Conclusions/interpretation

Our high-resolution histomorphological analysis of human pancreatic islets from donors with and without diabetes has uncovered details of the cellular origin of islet prohormone peptide processing defects. Reduced beta cell PC1/3 and increased alpha cell PC1/3 in islets from donors with type 1 diabetes pinpointed the functional deterioration of beta cells and the concomitant potential increase in PC1/3 usage for prohormone processing in alpha cells during the pathogenesis of type 1 diabetes. Our finding of PC1/3 loss in beta cells may inform the discovery of new prohormone biomarkers as indicators of beta cell dysfunction, and the finding of elevated PC1/3 expression in alpha cells may encourage the design of therapeutic targets via leveraging alpha cell adaptation in diabetes.

Graphical Abstract
Designing sustainable diet plans by solving triobjective integer programs
Authors: Benvenuti Luca , De Santis Alberto , De Santis Marianna , Patria Daniele
Published: October 2024

We present an algorithm for triobjective nonlinear integer programs that combines the

$$\varepsilon $$

ε

-constrained method with available oracles for biobjective integer programs. We prove that our method is able to detect the nondominated set within a finite number of iterations. Specific strategies to avoid the detection of weakly nondominated points are devised. The method is then used to determine the nondominated solutions of triobjective 0–1 models, built to design nutritionally adequate and healthy diet plans, minimizing their environmental impact. The diet plans refer to menus for school cafeterias and we consider the carbon, water and nitrogen footprints as conflicting objectives to be minimized. Energy and nutrient contents are constrained in suitable ranges suggested by the dietary recommendation of health authorities. Results obtained on two models and on real world data are reported and discussed.
Sacrocolpopexy: The Way I Do It
Authors: Shahid Usama , Chen Zhouran , Maher Christopher
Published: October 2024

Introduction and Hypothesis

Sacrocolpopexy (SCP) is an established surgical procedure for apical vaginal vault prolapse. There remains significant variation amongst surgeons in both the surgical steps and concomitant surgeries utilised when undertaking an SCP.

Methods

This review article is aimed at summarising the evidence and providing a detailed update of SCP in modern practice, reviewing contemporary evidence behind its indications, efficacy, outcomes, surgical steps, and complications.

Results

Sacrocolpopexy remains the gold standard for post-hysterectomy apical prolapse based on good long-term outcomes, patient satisfaction and low complication rates. SCP with concomitant total hysterectomy is not recommended owing to high rates of mesh exposure. The laparoscopic approach remains the preferred option in terms of low morbidity, quicker recovery and lower cost than alternative access options. For optimal outcomes an SCP should be performed with monofilament mesh, using absorbable sutures and with a paravaginal repair for cystocele.

Conclusions

Although SCP has become increasingly utilised for apical prolapse, its established efficacy regarding anatomical outcomes, patient satisfaction, and complications is in the context of post-hysterectomy prolapse. SCP with concomitant total hysterectomy has higher rates of mesh exposure. The efficacy and safety of SCP with sub-total hysterectomy or hysteropexy have not been clearly established and require further assessment through well-designed, rigorous randomised controlled trials.
Extreme enthalpy‒entropy compensation in the dimerization of small solutes in aqueous solution
Authors: Scott David J. , Winzor Donald J.
Published: October 2024

This communication summarizes findings from the earliest encounters with extreme enthalpy‒entropy compensation, a phenomenon first detected in the 1950s by a reappraisal of isopiestic and calorimetric measurements on aqueous urea solutions in terms of solute self-association. Because concurrent studies of carboxylic acid association were confined to measurement of the equilibrium constant by conductance, IR spectrophotometry or potentiometric titration measurements, temperature-independence of the dimerization constant was mistakenly taken to signify a value of zero for Δ$$H^o$$

H
o

instead of (Δ$$H^o$$

H
o

 ‒ TΔ$$S^o$$

S
o

). In those studies of small-solute self-association the extreme enthalpy‒entropy compensation was reflecting the action of water as a reactant whose hydroxyl groups were competing for the solute carbonyl involved in self-association. Such action gives rise to a positive temperature dependence of Δ$$H^o$$

H
o

that could well be operating in concert with that responsible for the commonly observed negative dependence for protein‒ligand interactions exhibiting extreme enthalpy‒entropy compensation, where the solvent contribution to the energetics reflects changes in the extent of ordered water structure in hydrophobic environments.
Quantitative Assessment of New Frontiers in Dermatochalasis and Periorbital Hyperpigmentation Treatment: The Role of Cross-Linked Porcine Collagen
Authors: Chuang Andy Deng-Chi , Lin Erh-Ti , Wu Bing-Qi , Lu Meng-En , Chiang Hsiu-Mei , Chu Pai-Nien , Lin Bor-Shyh , Chang Chang-Cheng
Published: October 2024

Background

Collagen dermal fillers have shown efficacy in addressing age-related changes in facial appearance. However, their potential in rejuvenating the periorbital region remains unexplored. The aim of this study was to evaluate the effectiveness, clinical safety, and patient satisfaction associated with the utilization of collagen dermal fillers in individuals with dermatochalasis and periorbital hyperpigmentation.

Methods

This study was reviewed and approved by the institutional review board of China Medical University Hospital (IRB No. CMUH107-REC2-157). Adults diagnosed with dermatochalasis or periorbital hyperpigmentation received periorbital injections of a sterile cross-linked highly-purified specific antigen free porcine dermal collagen (FACIALGAIN® Collagen Implant with Lidocaine, Sunmax Biotechnology Co. Ltd., Taipei, Taiwan) and were assessed for hydration, elasticity, pigmentation index, redness index, lightness value, and density with the DermaLab® Combo Multiparameter Skin Analysis System (Cortex Technology, Hadsund, Denmark) and Cutometer® Dual MPA 580 (Courage+Khazaka electronic GmbH, Köln, Germany). Data was collected prior to injection and at 1 week, 4 weeks, and 12 weeks after injection. Patient satisfaction on volume augmentation, decrease in hyperpigmentation, persistence, and overall satisfaction were also recorded.

Results

A total of 12 samples each were recruited for dermatochalasis and periorbital hyperpigmentation. For dermatochalasis subjects, hydration of the periorbital tissue significantly increased at week 1 and 4 (p = 0.011 and p = 0.015). Elasticity decreased by week 4 and persisted until week 12 (p = 0.001 and 0.014). For periorbital hyperpigmentation patients, lightness value increased significantly starting week 1 (p = 0.016), tapering off at week 12. Elasticity decreased by week 4 and persisted until week 12 (p = 0.002 and p = 0.002). Median overall patient satisfaction was 4 out of 5 for the dermatochalasis group and 4.5 out of 5 for the periorbital hyperpigmentation group, with a mild but insignificant decrease by week 12.

Conclusions

DermaLab® Combo and Cutometer® Dual MPA 580 are considered effective methods for evaluating patients undergoing dermal filler injections. The utilization of cross-linked porcine collagen dermal filler injections can serve as a minimally invasive approach to enhance skin laxity in dermatochalasis and address discoloration in periorbital hyperpigmentation. However, it is important to note that regular treatments may be necessary to sustain the desired outcomes.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/0026.
Percutaneous Cryoablation in the Liver: A Meta-Analysis and Review of Safety with a Focus on Incidence of Cryoshock and Major Complications
Authors: Kolck Johannes , Schulze Daniel , Brönnimann Michael , Fürstner Matthias , Fehrenbach Uli , Collettini Federico , Gebauer Bernhard , Auer Timo A.
Published: October 2024

Purpose

The aim of the present meta-analysis was to systematically determine the overall complication rate and incidence of cryoshock in patients undergoing cryoablation of the liver.

Methods

A systematic review and meta-analysis adhering to the PRISMA guidelines and focusing on studies of cryotherapy for liver malignancies published after 2000 were conducted. PubMed, Web of Science, Embase, and Scopus were systematically searched for articles reporting incidences of adverse events associated with percutaneous cryoablation in patients with liver malignancies. Data extraction and screening were independently conducted by two reviewers, who resolved discrepancies through consensus. Statistical analysis was performed to assess heterogeneity and pooled complication rates and included a moderator analysis to explore factors influencing the occurrence of complications.

Results

The initial search yielded 4,145 articles, of which 26 met our inclusion criteria. From these 26 articles, pooled data on 4,029 patients were extracted. Variance between studies reporting cryoshock was low (I2 = 13.15%), while variance among studies reporting major complications was high (I2 = 82.52%). The pooled weighted proportion of major complications was 4.71% while that of cryoshock was as low as 0.265%. Moderator analysis identified publication year as the only moderator for major complications and no moderator for the occurrence of cryoshock.

Conclusion

Analysis of currently available evidence indicates that cryoablation has a relative safe profile with a pooled incidence of major complications below 5%. Cryoshock occurred in less than 0.3% of procedures and was not reported for liver lesions smaller than 3 cm.
Enhanced transanal surgery training through a 4K 3D surgical exoscope: a novel approach for transanal surgery
Authors: Spinelli Antonino , Chardalias Leonidas , Carvello Michele , Sacchi Matteo , Siragusa Leandro , La Raja Carlotta
Published: October 2024

Purpose

Recently, exoscope was introduced as a more ergonomic alternative to microscope, mainly in nerve and spinal surgery. Exoscope use in general surgery is still experimental and just few reports are present in literature. Here, we describe for the first time its application in transanal surgery, specifically during the transanal transection and single-stapled anastomosis in ileal-pouch anal anastomosis.

Methods

After completing the proctectomy and pouch formation laparoscopically, two surgeons performed the transanal transection and single-stapled anastomosis using the vision provided by the ORBEYE™ exoscope system with a 3D 4K orbital camera and a 55-inches 3D screen. The transanal procedure was carried out with the surgeons looking at the 3D screen rather than at the operating field.

Results

The system subjectively provided excellent operative view thanks to the magnification capacity and the high resolution. The ergonomics was improved compared to classical transanal surgery, allowing the operators and observers to have the same view in a comfortable position. In particular, the exoscope magnified vision allowed for clearer demonstration of techniques to trainees.

Conclusions

This is the first report on the intraoperative application of the ORBEYE™ surgical exoscope in transanal surgery. The magnified vision allowed precise movements and the system appeared potentially a ground-breaking tool for surgical training. The ability to project high-quality images to observers make it ideal for teaching complex transanal procedures. Further studies are encouraged to validate this approach into standard colorectal practice.
Innovations in ultrasound training in obstetrics
Authors: Wittek Agnes , Strizek Brigitte , Recker Florian
Published: October 2024

Introduction

Ultrasound technology is critical in obstetrics, enabling detailed examination of the fetus and maternal anatomy. However, increasing complexity demands specialised training to maximise its potential. This study explores innovative approaches to ultrasound training in obstetrics, focussing on enhancing diagnostic skills and patient safety.

Methods

This review examines recent innovations in ultrasound training, including competency-based medical education (CBME), simulation technologies, technology-based resources, artificial intelligence (AI), and online-learning platforms. Traditional training methods such as theoretical learning, practical experience, and peer learning are also discussed to provide a comprehensive view of current practises.

Results

Innovations in ultrasound training include the use of high-fidelity simulators, virtual reality (VR), augmented reality (AR), and hybrid-learning platforms. Simulation technologies offer reproducibility, risk-free learning, diverse scenarios, and immediate feedback. AI and machine learning facilitate personalised-learning paths, real-time feedback, and automated-image analysis. Online-learning platforms and e-learning methods provide flexible, accessible, and cost-effective education. Gamification enhances learning motivation and engagement through educational games and virtual competitions.

Discussion

The integration of innovative technologies in ultrasound training significantly improves diagnostic skills, learner confidence, and patient safety. However, challenges such as high costs, the need for comprehensive instructor training, and integration into existing programs must be addressed. Standardisation and certification ensure high-quality and consistent training. Future developments in AI, VR, and 3D printing promise further advancements in ultrasound education.

Conclusion

Innovations in ultrasound training in obstetrics offer significant improvements in medical education and patient care. The successful implementation and continuous development of these technologies are crucial to meet the growing demands of modern obstetrics.
Conventional one-handed compared to two-handed endoscopic ear surgery using an endoscope holder: a single center study
Authors: Müller Christoph , Raczynski Anastasia , Lailach Susen , Zahnert Thomas
Published: October 2024

Introduction

One-handedness is a challenge in conventional endoscopic ear surgery (EES). We present results on the first-ever application of the passive endoscope holder ‘Endofix exo’ (Co. AKTORmed GmbH, Neutraubling, Germany) in EES, which enables two-handed surgery.

Methods

This two-sided study compares cut-suture time, operating time, postoperative complications, graft take rates, hearing results and quality of life in patients who underwent first stage tympanoplasty due to tympanic membrane perforation with intact ossicular chain conditions. 25 patients received classic EES (EES-, mean age: 28 ± 21 years) and 15 received EES with the passive holder (EES+, mean age: 48 ± 21 years).

Results

Mean operating times (EES-: 96 ± 38 (SD) min; EES+: 107 ± 33 min), cut-suture times (EES-: 68 ± 30 min; EES+: 73 ± 31 min), complications, graft take rates and hearing results (preoperative air bone gap (ABG) (PTA4): 15 dB ± SD 8 dB (EES-); 16 dB ± SD 8 dB (EES+); postoperative ABG (PTA4): 11.25dB ± SD 11.3dB (EES-); 14 dB ± SD 10 dB (EES+)) did not differ significantly (p > 0.05) between the two groups. Postoperative hearing results and quality of life tended to improve in both groups (p > 0.05).

Discussion

The passive endoscope holder has been successfully applied during the course of the study. However, modifications of the endoscope holder and further studies are recommended focusing on positioning of grafts and prostheses to obtain conclusive results regarding the superiority of two-handed EES over one-handed conventional EES.
Changes in weight secondary to improved odor perception in chronic rhinosinusitis with nasal polyps’ patients treated with Dupilumab
Authors: Rosso Cecilia , De Corso Eugenio , Urbanelli Anastasia , Fadda Gianluca , Saibene Alberto Maria , Ferella Francesco , Spanu Camilla , Pipolo Carlotta
Published: October 2024

Purpose

The advent of biologic therapies, notably Dupilumab, has transformed therapeutic approaches to nasal polyposis. This retrospective multicentric study aimed to investigate weight changes in CRSwNP patients undergoing Dupilumab treatment and explore potential correlations with olfactory improvement.

Methods

Ninety-six patients with CRSwNP were followed for at least 12 months, with assessments including BMI (Body Mass Index), olfactory function, and disease severity.

Results

Significant increases in BMI and olfactory perception were observed after 1 year of Dupilumab treatment (p < .001). Subgroup analysis showed that patients with hyposmia and normosmia at T12 (1-year follow up) experienced significant weight gain (p < .001) alongside improved olfaction (both p < .001). Conversely, patients with anosmia after 1 year of therapy and also patients with stable or worsened olfaction did not show significant BMI changes (respectively p = .201 and p = .107).

Conclusion

While these findings suggest a correlation between olfactory improvement and weight gain/BMI, factors like improved nasal airflow and corticosteroid cessation under Dupilumab treatment may also influence weight in CRPwNP patients. The study highlights the need for further research to elucidate the causal relationship and long-term implications of Dupilumab-induced olfactory improvement on weight regulation.
Effect of Fresnel prism in small-angle esotropia (≤ 20 prism diopters) with fixation preference
Authors: Joo Hye Jun , Kim Seong-Joon
Published: October 2024

Purpose

We aimed to investigate the effects of Fresnel prism treatment for small-angle esotropia (≤ 20 prism diopters [PD]) with fixation preference.

Methods

We included 32 patients with remaining esotropia ≤ 20 PD measured using the simultaneous prism and cover test (SPCT) after full refractive error correction. Fresnel prism was applied to make patients orthotropic with glasses. Treatment was discontinued if remaining esotropia ≤ 4 PD was sustained during two consecutive follow-ups (2-month intervals) or if the angle continued to increase with prism adaptation. Patients were divided into treatment success and failure groups. Treatment success was defined by motor and visual acuity (VA) aspects. Criteria for motor success was residual esotropia ≤ 8 PD in patients with initial esotropia > 8 PD and a 30% decrease of esotropia in those with initial esotropia ≤ 8 PD. VA success was improvement of > 0.2 logMAR in the non-dominant eye.

Results

The initial esodeviation angle was 6.92 ± 4.66 PD at distance and 10.53 ± 5.58 at near. The logMAR VA was 0.10 ± 0.13 and 0.26 ± 0.20 in the dominant and non-dominant eye, respectively. Among the 32 patients, 14 showed motor success. Among 26 patients whose VA could be measured, 15 showed VA success. Factors influencing motor success were a small amount of maximum prescribed Fresnel prism, less frequent need for Fresnel prism adaptation, and high percentage of achieving orthotropia with Fresnel prism treatment. VA success was influenced by low frequency of anisometropia and the small amount of maximum prescribed Fresnel prism.

Conclusion

Fresnel prism could be a non-invasive treatment option for some patients with small-angle esotropia with fixation preference.

Key messages

What is known

The optimal approach for addressing small-angle esotropia is a topic of debate.

Not much research has been conducted on Fresnel prism treatment in patients with small-angle esotropia.

What is new

Motor success and visual acuity improvement were observed in some patients undergoing Fresnel prism treatment.

Factors contributing to motor success were the small maximum angle of esodeviation, the less frequent necessity for Fresnel prism adaptation, and the achievement of orthotropia during Fresnel prism treatment.

Visual acuity improvement was hindered by the presence of anisometropia and the large maximum prescribed amount of Fresnel prism.

Fresnel prism treatment can be used as a treatment option for some patients with small-angle esotropia with fixation preference.
Mortality of alzheimer’s disease in Italy from 1980 to 2015
Authors: Bezzini Daiana , Smeralda Carmelo L. , Pasqualetti Patrizio , Cappa Stefano F. , Kundisova Lucia , Rossi Simone , Ulivelli Monica
Published: October 2024

Objective

To evaluate mortality for Alzheimer’s Disease (AD) in Italy over more than three decades (1980–2015) and discuss the possible role of general and specific contributing factors.

Methods

Mortality data were extracted by the Italian National Institute of Statistics: crude mortality rates were computed for sex and age, considering the whole country and its five main geographical sub-areas. Rates were standardized in two ways: directly (annual mortality rates AMRs) and indirectly (standardized mortality rates, SMRs). SMRs were then used to evaluate geographical differences; to study mortality trend, AMRs and joinpoint linear regression analysis were used.

Results

Considering the entire period and the whole country, mortality rates were similar for females and males and for geographical regions, with the exception of the older age groups where mortality for AD in females slightly prevailed. In these older patients, a steep increase of mortality was seen starting from the current century. The increase in male mortality mirrored the national trend in North-West and Central Italy, but not in North-East, South, and the Islands, where it did not surge until the mid to late 1990s.

Conclusions

the general increase of mortality is in line with international data and it reflects the increasing prevalence of the disease, likely due to increasing longevity, and to improvements in diagnostic accuracy. In addition, the accuracy of death certificate compilation could account for both geographical and temporal differences. Currently available drugs for AD do not seem to have an impact on mortality rates.
Bacterial isolates from drinking water river sources exhibit multi-drug resistant trait
Authors: Popoola Bukola Margaret , Ogwerel Jemimah Pearl , Oladipo Oluwatosin Gbemisola
Published: October 2024

Freshwater habitat is a natural reservoir for antimicrobial resistance (AMR). AMR poses serious human, animal, and environmental public health threats. This study aimed to evaluate the physicochemical and microbiological quality of five selected rivers (Apitipiti 1, Apitipiti 2, Apitipiti 3, Sogidi, and Aba Apa Akinmorin) in Oyo town, Nigeria, as well as the antibiotic resistance pattern of isolated bacterial species, using conventional methods. Most physicochemical parameters were within WHO and NIS permissible limits. Pearson’s correlation matrix indicated that there were significant (p < 0.05) interactions among pH, electrical conductivity, temperature, sulphate and chloride salts, and BOD and COD. A total of thirty-two (32) bacterial species were isolated and identified as: Aeromonas (9), Bacillus (2), Corynebacterium (13), Lactobacillus (1), Pseudomonas (2), Staphylococcus (4), and Streptococcus (1). Of the rivers, Sogidi had the highest microbial load (6.36 log CFU/mL) while Apititipiti 1 had the lowest (5.76 log CFU/mL). With regard to antibiotic sensitivity, 81.8% were multidrug-resistant, with Corynebacterium kutscheri and Aeromonas spp. isolated from Apitipiti 2 and Aba Apa Akinmorin rivers, respectively, exhibiting a relatively high antibiotic resistance of 90.9%. This study reveals that these rivers may be unfit for consumption as multidrug-resistant bacteria of public health risk were associated with them.
Bringing Traditional Medicine into the Health Humanities Classroom with Kali Fajardo-Anstine’s “Remedies”
Authors: Libow Jess , Grubbs Lindsey
Published: October 2024

In this essay, we recommend Kali Fajardo-Anstine’s short story “Remedies” (2019) for inclusion on health humanities syllabi based on our experiences teaching it at two undergraduate institutions. The story is drawn from Sabrina & Corina, Fajardo-Anstine’s award-winning book of short stories about Chicana and Indigenous women in Colorado, but is available for free online, making it highly accessible for students. “Remedies” is narrated by Clarisa, who turns to her great-grandmother Estrella for the traditional knowledge that ultimately cures her family’s recurrent outbreaks of lice. As a health narrative that centers familial and cultural healing practices, “Remedies” offers a much needed counterpart to the biomedical frameworks that tend to dominate health humanities syllabi and curricula. At the same time that it illuminates the physical and emotional efficacy of such practices, “Remedies” rejects a binary that pits them against biomedicine, offering a complex portrait of how various members of a family integrate traditional and biomedical approaches to health. We discuss how themes related to familial and cultural healing practices are developed in the story and introduce our approach to initiating productive conversations about the relationship between traditional healing and biomedicine in our classrooms.
Landslide displacement prediction using time series InSAR with combined LSTM and TCN: application to the Xiao Andong landslide, Yunnan Province, China
Authors: Li Jia , Fan Chengpeng , Zhao Kang , Zhang Zhike , Duan Ping
Published: October 2024

Research on landslide displacement prediction based on interferometric synthetic aperture radar (InSAR) deformation data involves two main issues. First, InSAR can provide only one-dimensional deformation data along the satellite’s line of sight (LOS), which cannot truly reflect the deformation of the landslide body in the downward direction along the slope. Second, the use of a single prediction model does not adequately account for both long-term and local changes in landslide displacement, affecting the accuracy of the predictions. To address this, in this study, Long Short-Term Memory networks (LSTM) and temporal convolutional network (TCN) models are combined to construct a method (LSTM-TCN) of landslide displacement prediction. This method can consider the long-term and localized changes in landslide displacement. The method is first based on InSAR technology to obtain surface deformation. The deformation of the landslide is subsequently computed in the downward direction along the slope to obtain the landslide displacement time series data. Next, the LSTM-TCN is used for landslide displacement prediction. Finally, the mean absolute error (MAE), root mean square error (RMSE) and coefficient of determination (R2) are used to evaluate the performance of the model. The experiment is conducted on the Xiao Andong landslide in Anshi village, Fengqing County, Lincang City, Yunnan Province, China. The LSTM-TCN model achieves an R2 of 0.75, an RMSE of 0.43 cm, and an MAE of 0.36 cm. Compared with the individual LSTM and TCN models, the LSTM-TCN model exhibits the highest prediction accuracy and the smallest prediction error, which is closer to the true result that in the other models. These results demonstrate that the combined LSTM-TCN model effectively captures the complex features and long-term trends in landslide displacement data, significantly enhancing the accuracy of predictions.
Development of morphological awareness in Arabic: the role of morphological system and morphological distance
Authors: Shahbari-Kassem Abeer , Schiff Rachel , Saiegh-Haddad Elinor
Published: October 2024

This study is a cross-sectional developmental investigation of inflectional and derivational morphological awareness (MA) in Arabic diglossia. It examines the impact of the morphological distance between Spoken Arabic (SpA) and Standard Arabic (StA) on inflectional morphological awareness and derivational morphological awareness in a sample of 200 speakers of Palestinian Arabic (PA) in 2nd through 10th grade from mid-high and low SES backgrounds (N = 40 per grade, 20 per SES group). Eight MA tasks using morphological analogies and sentence completion were used that tested inflectional MA and derivational MA in SpA and in StA. Results showed a growth in inflectional and in derivational awareness across grades in both SES groups despite generally higher scores in the mid-high SES group. More interestingly, the results showed a consistent effect of morphological distance on morphological awareness in both morphological systems and in both SES groups, with MA for unique StA morphological structures lower than that for structures available in SpA. Moreover, the impact of morphological distance was more prominent in younger than in older children and in low than in mid-high SES. Finally, when morphological awareness in SpA was tested, inflectional awareness was higher than derivational awareness and showed a shorter cross-sectional developmental trajectory, reflecting universal linguistic and distributional properties of inflections. In contrast, when morphological awareness in StA was analyzed, inflectional awareness was lower than derivational awareness and showed a longer trajectory reflecting the wider linguistic distance between SpA and StA in inflectional morphology. The results underscore the significance of morphological system characteristics and morphological distance in understanding morphological awareness development in Arabic.
Open access improves the dissemination of science: insights from Wikipedia
Authors: Yang Puyu , Shoaib Ahad , West Robert , Colavizza Giovanni
Published: October 2024

Wikipedia is a well-known platform for disseminating knowledge, and scientific sources, such as journal articles, play a critical role in supporting its mission. The open access movement aims to make scientific knowledge openly available, and we might intuitively expect open access to help further Wikipedia’s mission. However, the extent of this relationship remains largely unknown. To fill this gap, we analyse a large dataset of citations from the English Wikipedia and model the role of open access in Wikipedia’s citation patterns. Our findings reveal that Wikipedia relies on open access articles at a higher overall rate (44.1%) compared to their availability in the Web of Science (23.6%) and OpenAlex (22.6%). Furthermore, both the accessibility (open access status) and academic impact (citation count) significantly increase the probability of an article being cited on Wikipedia. Specifically, open access articles are extensively and increasingly more cited in Wikipedia, as they show an approximately 64.7% higher likelihood of being cited in Wikipedia when compared to paywalled articles, after controlling for confounding factors. This open access citation effect is particularly strong for articles with high citation counts or published in recent years. Our findings highlight the pivotal role of open access in facilitating the dissemination of scientific knowledge, thereby increasing the likelihood of open access articles reaching a more diverse audience through platforms such as Wikipedia. Simultaneously, open access articles contribute to the reliability of Wikipedia as a source by affording editors timely access to novel results.
Novel combined pharmacological strategy to alleviate acute phase response following zoledronic acid treatment
Authors: Chen Chung-Hwan , Yeap En Kee , Hsu Chia-Hao , Lu Yen-Mou , Cheng Tsung-Lin , Lee Tien-Ching , Ho Cheng-Jung , Li Jhong-You , Shen Hsin-Yi , Huang Hsuan-Ti , Lu Cheng-Chang , Lin Sung-Yen
Published: October 2024

Summary

Brief rationale: Zoledronic acid treatment against osteoporosis is limited by APR. Main result: Combination therapy (hydrocortisone plus non-steroidal anti-inflammatory drugs, acetaminophen, and prednisolone) reduced intolerable APR levels and provided complete symptom relief in most patients. Significance of the paper: Combination therapy can enhance patient outcomes in osteoporosis management.

Purpose

Osteoporosis is a common condition associated with high morbidity rates, often requiring treatment with bisphosphonates such as zoledronic acid. However, the persistence to zoledronic acid infusion is commonly limited by acute phase response (APR). This retrospective study aimed to evaluate the efficacy of a novel combination therapy in preventing APR symptoms.

Methods

A retrospective case–control study was conducted on 931 patients who received their first zoledronic acid infusion between 2011 and 2021. We evaluated the efficacy of combination therapy comprising a single dose of hydrocortisone prior to the infusion and a 3-d oral regimen of non-steroidal anti-inflammatory drugs, acetaminophen, and prednisolone following the infusion. Patients were divided into protocol (receiving combination therapy) and control groups (without treatment). Baseline characteristics, APR incidence, and the efficacy of symptom control were compared between groups using Fisher’s exact test and Student’s t-test.

Results

There was no difference in APR incidence between the protocol (n = 507) and control group (n = 407; p = 0.1442). However, the protocol group exhibited lower intolerable APR levels (3.72% vs. 16.71%; p < 0.0001) and complete symptom relief in 96.28% of cases.

Conclusion

The combination therapy protocol effectively reduced intolerable APR and relieved symptoms in most patients following zoledronic acid infusion. This study highlights the importance of proactive management strategies for APR and emphasizes the potential of combination therapy in alleviating APR symptoms and reducing the occurrence of severe APR in patients undergoing osteoporosis management.
Low-Temperature Sintering of Colloidal Gold Nanoparticles by Salt Addition
Authors: Catanzaro L. , Scardaci V. , Scuderi M. , Condorelli M. , D’Urso L. , Compagnini G.
Published: October 2024

Gold nanoparticles synthetized by pulsed laser ablation in liquid with a mean diameter of 4 nm were joined together by adding potassium bromide solution at various concentrations. By increasing the salt concentration, there is a significant increase of the particle size up to a mean diameter of 18 nm. We have studied the nanoparticle merging by using atomic force and electron microscopy characterizations, also demonstrating that it is possible to deposit sintered nanoparticles on silanized substrates in a fast, simple, cost-effective, energy-saving method with relevance in industrial manufacturing.
South! Phylogeography of the Antarctic fairy shrimp Branchinecta gaini and its closest Patagonian congener Branchinecta granulosa reveals a long-term association of freshwater fauna with the southern continent
Authors: Pokorný Matěj , Cohen Rosa Graciela , Nedbalová Linda , Lirio Juan Manuel , Sacherová Veronika
Published: October 2024

Branchinecta gaini Daday, 1910 is the southernmost extant Anostracan species occurring in various localities across Maritime Antarctica. Since this region was almost completely glaciated during the Last Glacial Maximum, the identification of potential glacial refugia and the colonization sequence of freshwater habitats within Maritime Antarctica remains primary biogeographic objective for understanding the evolution of the Antarctic environment. To evaluate the history of B. gaini in Maritime Antarctica, we performed phylogeographic analyses of B. gaini and its closest Patagonian congener Branchinecta granulosa Daday, 1902. We sampled 47 populations from all three Antarctic bioregions where B. gaini occurs – South Orkney Islands, North-west and North-east Antarctic Peninsula. B. granulosa was represented by 8 populations from Patagonia. Molecular analyses of two mitochondrial (16S, COI) and one nuclear (ITS2) marker showed low overall mitochondrial variability and the ambiguous nature of ITS2 variability. The species assessment revealed insufficient genetic differentiation between B. gaini and B. granulosa to consider them two separate species. Therefore, the widely accepted idea that there is a species of Branchinecta endemic to Antarctica and sub-Antarctic islands should be omitted, and B. gaini should be synonymized with B. granulosa. Molecular clock analysis of COI for two substitution rates dated the separation of B. gaini from B. granulosa to the Pleistocene (170 – 502 ka BP and 17 – 50 ka BP, respectively). Therefore, Antarctic populations of B. gaini separated from Patagonian B. granulosa before or during the Last Glacial Maximum, indicating an older association with the southern continent than previously anticipated. The geographic distribution of haplotypes further suggests that B. gaini most likely survived at least the last glacial period in an as-yet unknown refugium in Antarctica.
Coercive public health policies need context-specific ethical justifications
Authors: Johnson Tess , Ndlovu Lerato , Baiyegunhi Omolara O. , Lora Wezzie S. , Desmond Nicola
Published: October 2024

Public health policies designed to improve individual and population health may involve coercion. These coercive policies require ethical justification, and yet it is unclear in the public health ethics literature which ethical concepts might justify coercion, and what their limitations are in applying across contexts. In this paper, we analyse a number of concepts from Western bioethics, including the harm principle, paternalism, the public interest, and a duty of easy rescue. We find them plausible justifications for coercion in theory, but when applied to case studies, including HIV testing in Malawi, vaccine mandates in South Africa, and prohibitions of antibiotic use in livestock in the EU, their limitations become clear. We argue that the context-specificity of ethical justifications for coercion has been overlooked, and there is more work needed to identify context-relevant ethical justifications for coercive policies in various settings and for various populations, rather than relying on universalising Western bioethical justifications across all contexts.
Is that SMART? Leveraging Collaboration and Peer Feedback to Enable Practice in Appraising and Presenting Journal Articles
Authors: Worden Mary Kate
Published: October 2024

In an innovative journal club exercise, groups of students collaboratively appraise and present a journal article and then provide SMART narrative feedback to a peer group on their presentation. Feedback is exchanged between groups that presented the same journal article, increasing the likelihood that feedback will be meaningful and high-quality.
Porous Organic Cage-Based Quasi-Solid-State Electrolyte with Cavity-Induced Anion-Trapping Effect for Long-Life Lithium Metal Batteries
Authors: Qin Wei-Min , Li Zhongliang , Su Wen-Xia , Hu Jia-Min , Zou Hanqin , Wu Zhixuan , Ruan Zhiqin , Cai Yue-Peng , Li Kang , Zheng Qifeng
Published: October 2024

Porous organic cages (POCs) with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior, yet their feasibility as solid-state electrolytes has never been testified in a practical battery. Herein, we design and fabricate a quasi-solid-state electrolyte (QSSE) based on a POC to enable the stable operation of Li-metal batteries (LMBs). Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC, the resulting POC-based QSSE exhibits a high Li+ transference number of 0.67 and a high ionic conductivity of 1.25 × 10−4 S cm−1 with a low activation energy of 0.17 eV. These allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 h. As a proof of concept, the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85% capacity retention after 1000 cycles. Therefore, our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems, such as Na and K batteries.
Weak Convergence of Probability Measures on Hyperspaces with the Upper Fell-Topology
Authors: Ferger Dietmar
Published: October 2024

Let E be a locally compact second countable Hausdorff space and $$\mathcal {F}$$
F
the pertaining family of all closed sets. We endow $$\mathcal {F}$$
F
respectively with the Fell-topology, the upper Fell topology or the upper Vietoris-topology and investigate weak convergence of probability measures on the corresponding hyperspaces with a focus on the upper Fell topology. The results can be transferred to distributional convergence of random closed sets in E with applications to the asymptotic behavior of measurable selections.
Non-exchange bias hysteresis loop shifts in dense composites of soft-hard magnetic nanoparticles: New possibilities for simple reference layers in magnetic devices
Authors: Maltoni Pierfrancesco , López-Martín Raúl , Sánchez Elena H. , Normile Peter S. , Vasilakaki Marianna , Lee Su Seong , Burgos Benito Santos , del Castillo Eloy A. López , Peddis Davide , Binns Chris , Trohidou Kalliopi , Mathieu Roland , Nogués Josep , De Toro José A.
Published: October 2024

Exchange bias has been extensively studied in both exchange-coupled thin films and nanoparticle composite systems. However, the role of non-exchange mechanisms in the overall hysteresis loop bias is far from being understood. Here, dense soft-hard binary nanoparticle composites are used not only as a novel tool to unravel the effect of dipolar interactions on the hysteresis loop shift but also as a new strategy to enhance the bias of any magnet exhibiting an asymmetric magnetization reversal. Mixtures of equally sized, 6.8 nm, soft maghemite (γ-Fe2O3) nanoparticles (no bias—symmetric reversal) and hard cobalt doped γ-Fe2O3 nanoparticles (large exchange bias—asymmetric reversal) reveal that, for certain fractions of soft particles, the loop shift of the composite can be significantly larger than the exchange-bias field of the hard particles in the mixture. Simple calculations indicate how this emerging phenomenon can be further enhanced by optimizing the parameters of the hard particles (coercivity and loop asymmetry). In addition, the existence of a dipolar-induced loop shift (“dipolar bias”) is demonstrated both experimentally and theoretically, where, for example, a bias is induced in the initially unbiased γ-Fe2O3 nanoparticles due to the dipolar interaction with the exchange-biased hard nanoparticles. These results open a new paradigm in the large field of hysteresis bias and pave the way for novel approaches to tune loop shifts in magnetic hybrid systems beyond interface exchange coupling.
Student-created videos in online STEM education: a large, interdisciplinary, randomized control study
Authors: Atkinson Alvina , Bell Patrice , De La Rosa Indhira , DeGeorge Tonya , Jonassen Lorraine , Kokil Vinavtee , Lee Seungjin , Malloy Mia , Pinzon Katherine , Robertson Cindy , Savage Jamye Curry , Shahbaz Rabia , Villanueva Omar , Wludyga Joshua , Morris Joshua
Published: October 2024

Student-created videos engage students’ interests, creativity, and content knowledge and enrich collaborative learning in STEM education. These videos enhance critical thinking and analytical skills, which are essential tools in the fields of science, technology, engineering, and mathematics (STEM). This study presents the results of such an assignment across several STEM areas (biology, chemistry, exercise science, information technology, and mathematics) at a minority-serving, liberal arts higher education institution in the southeast region of the United States. Undergraduate students (n = 557) across varied, online course modalities (synchronous and asynchronous) were required to create four problem-solving videos 3–8 min in duration. Assessment tools included a self-assessment of learning gains survey given to control and experimental groups and a post-video creation survey given only to experimental groups. Grade data was also collected from all sections. Comparing the experimental and control groups, students showed a statistically significant gain in their ability to give oral presentations, create videos, and edit videos. Qualitative data from free-response questions corroborate these gains and suggest that students also grew in content knowledge and conceptual understanding through these assignments. Our study implements a multimedia theoretical framework which suggests students learn more effectively from consuming presentations with both auditory and visual components. Our results suggest students see similar gains from producing presentations with both auditory and visual components. Further our results suggest that multimedia production enhances students’ presentation skills. From a practical perspective, this study suggests that faculty should incorporate student-created videos in online classes, which typically require oral presentations in person. Faculty are also advised to require oral and visual components within these videos to maximize learning gains from the perspective of a multimedia theoretical framework.