bluuebunny/crossref_metadata_2025 huggingface dataset:
Two Nucleophilic Mutants of the Micromonospora viridifaciens Sialidase Operate with Retention of Configuration by Two Different Mechanisms
Authors: Watson Jacqueline N. , Newstead Simon , Narine Arun A. , Taylor Garry , Bennet Andrew J.
Published: October 2005

Mutants of the Micromonospora viridifaciens sialidase, Y370E and Y370F, are catalytically active retaining enzymes that operate by different mechanisms. Previous substitutions with smaller amino acids, including Y370D, yielded inverting sialidases. At least one water molecule can fit into the active‐site cavity of this mutant and act as a nucleophile from the face opposite the leaving group (Biochemistry 2003, 42, 12 682). Thus, addition of a CH2 unit (Asp versus Glu) changes the mechanism from inversion back to retention of configuration. Based on Brønsted βlg values, it is proposed that the Y370E mutant reacts by a double‐displacement mechanism (βlg on kcat/Km −0.36±0.04) with Glu370 acting as the nucleophile. However, the Y370F mutant (βlg on kcat/Km −0.79±0.12) reacts via a dissociative transition state. The crystal structure of the Y370F mutant complexed with 2‐deoxy‐2,3‐dehydro‐N‐acetylneuraminic acid shows no significant active‐site perturbation relative to the wild‐type enzyme.
The Expanding Role of Mass Spectrometry in Metabolite Profiling and Characterization
Authors: Want Elizabeth J. , Cravatt Benjamin F. , Siuzdak Gary
Published: October 2005

Mass spectrometry has a strong history in drug‐metabolite analysis and has recently emerged as the foremost technology in endogenous metabolite research. The advantages of mass spectrometry include a wide dynamic range, the ability to observe a diverse number of molecular species, and reproducible quantitative analysis. These attributes are important in addressing the issue of metabolite profiling, as the dynamic range easily exceeds nine orders of magnitude in biofluids, and the diversity of species ranges from simple amino acids to lipids to complex carbohydrates. The goals of the application of mass spectrometry range from basic biochemistry to clinical biomarker discovery with challenges in generating a comprehensive profile, data analysis, and structurally characterizing physiologically important metabolites. The precedent for this work has already been set in neonatal screening, as blood samples from millions of neonates are tested routinely by mass spectrometry as a diagnostic tool for inborn errors of metabolism. In this review, we will discuss the background from which contemporary metabolite research emerged, the techniques involved in this exciting area, and the current and future applications of this field.
Venture wire control catheter
Authors: McClure Samuel J. , Wahr Dennis W. , Webb John G.
Published: October 2005

We wished to test the safety and efficacy of a novel wire control catheter for use during percutaneous coronary intervention. The ability to vary the angulation of the tip of an intravascular guidewire would often be desirable. Previous attempts to produce deflectable‐tip guidewire systems have met with limited success. The Venture wire control catheter (Velocimed, Minneapolis, MN) was used to facilitate percutaneous coronary intervention in 20 patients. There were no device‐related complications. Percutaneous coronary intervention was successful in all patients. Our initial experience with the Venture wire control catheter has been favorable. © 2005 Wiley‐Liss, Inc.
(Sr2N)H: On the Redox‐Intercalation of Hydrogen into Sr2N.
Authors: Chemnitzer Rene , Auffermann Gudrun , Toebbens Daniel M. , Kniep Ruediger
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Barium Beryllates Ba[Be2N2] and Ba3[Be5O8]: Syntheses, Crystal Structures and Bonding Properties.
Authors: Leoni Stefano , Niewa Rainer , Akselrud Lev , Prots Yurii , Schnelle Walter , Goeksu Tahsin , Cetinkol Mehmet , Somer Mehmet , Kniep Ruediger
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
LiM2(NCN)Br3 (M: Sr, Eu): Synthesis and Crystal Structures of Solid‐State Carbodiimides with Empty Tetrahedral Metal Entities.
Authors: Liao Wuping , Dronskowski Richard
Published: October 2005

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Two Tantalum Fluorides Templated with tren: [H4tren](TaF7)2×H2O and [H4tren](TaF7)2.
Authors: Saada Mohamed Ali , Hemon‐Ribaud Annie , Smiri Laila Samia , Leblanc Marc , Maisonneuve Vincent
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
The Superstructure of Sc3RhC4 and Sc3IrC4.
Authors: Vogt Christian , Hoffmann Rolf‐Dieter , Poettgen Rainer
Published: October 2005

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Charge Transport and Optical Properties of MOCVD‐Derived Highly Transparent and Conductive Mg‐ and Sn‐Doped In2O3 Thin Films.
Authors: Ni Jun , Wang Lian , Yang Yu , Yan He , Jin Shu , Marks Tobin J.
Published: October 2005

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Study on Optical Properties of Rare‐Earth Ions in Nanocrystalline Monoclinic SrAl2O4: Ln (Ln: Ce3+, Pr3+, Tb3+).
Authors: Fu Zuoling , Zhou Shihong , Zhang Siyuan
Published: October 2005

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Design and Magnetic Properties of New Compounds Containing Iron 2D Building Blocks of the Perovskite Type.
Authors: Cario Laurent , Lafond Alain , Morvan Tangui , Kabbour Houria , Andre Gilles , Palvadeau Pierre
Published: October 2005

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Chemical Vapor Transport of Ternary Indium Molybdates.
Authors: Steiner Udo , Reichelt Werner
Published: October 2005

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A5InPb8 (A: K, Rb): An Apparent Zintl Phase with Lead Tetrahedra Interbridged by μ6‐In Atoms.
Authors: Klem Michael T. , Corbett John D.
Published: October 2005

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Synthesis, Crystal Structure, and Magnetic Properties of a Three‐Dimensional Hydroxide Sulfate: Mn5(OH)8SO4.
Authors: Fan Yong , Li Guang Hua , Yang Lei , Zhang Zhi Ming , Chen Yan , Song Tian You , Feng Shou Hua
Published: October 2005

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A Novel Modification of Manganese Orthophosphate Mn3(PO4)2.
Authors: Massa Werner , Yakubovich Olga V. , Dimitrova Olga V.
Published: October 2005

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Hydrothermal Synthesis, Crystal Structure, Spectroscopic and Magnetic Properties of (C3H12N2)0.75 [FeII1.5FeIII1.5 (AsO4)F6].
Authors: Bazan B. , Mesa J. L. , Pizarro J. L. , Pena A. , Arriortua M. I. , Rojo T.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
High Pressure Synthesis and Characterization of New Members of the RuSr2(Ln, Ce)2Cu2O10 Family (Ln: Y, Dy).
Authors: Gallardo‐Amores Jose Manuel , Martinez Jose Luis , Moran Emilio
Published: October 2005

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Stereochemical Study on α‐Alkylation of β‐Branched α‐Amino Acid Derivatives via Memory of Chirality.
Authors: Kawabata Takeo , Chen Jianyong , Suzuki Hideo , Fuji Kaoru
Published: October 2005

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Asymmetric 1,4‐Addition of Potassium Aryltrifluoroborates [ArBF3]K to Enones Catalyzed by Dicationic Palladium(II) Complexes.
Authors: Nishikata Takashi , Yamamoto Yasunori , Miyaura Norio
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic Asymmetric Vinylation and Dienylation of Ketones.
Authors: Li Hongmei , Walsh Patrick J.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Mechanism and Scope of Salen Bifunctional Catalysts in Asymmetric Aldehyde and α‐Ketoester Alkylation.
Authors: Fennie Michael W. , DiMauro Erin F. , O'Brien Erin M. , Annamalai Venkatachalam , Kozlowski Marisa C.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Michael Addition to α,β‐Unsaturated Imides Catalyzed by a Bifunctional Organocatalyst.
Authors: Hoashi Yasutaka , Okino Tomotaka , Takemoto Yoshiji
Published: October 2005

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Ionic Liquid as Catalyst and Reaction Medium. The Dramatic Influence of a Task‐Specific Ionic Liquid, [bmIm]OH, in Michael Addition of Active Methylene Compounds to Conjugated Ketones, Carboxylic Esters, and Nitriles.
Authors: Ranu Brindaban C. , Banerjee Subhash
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Design, Synthesis, and Reactivity of 1‐Hydrazinodienes for Use in Organic Synthesis.
Authors: Sammis Glenn M. , Flamme Eric M. , Xie Hao , Ho Douglas M. , Sorensen Erik J.
Published: October 2005

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A Rapid and Facile Synthesis of Isoxazolyl and Pyrazolyl Phenols from Enaminoketones Using Montmorillonite under Heterogeneous Catalytic Conditions.
Authors: Reddy G. Jagath , Rao K. Srinivasa , Khalilullah Md. , Latha D.
Published: October 2005

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Chemo‐ and Stereoselectivity in Titanium‐Mediated Regioselective Ring‐Opening Reaction of Epoxides at the More Substituted Carbon.
Authors: Tanaka Tetsuaki , Hiramatsu Kei , Kobayashi Yasutaka , Ohno Hiroaki
Published: October 2005

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Selective Oxidation of Benzylic Alcohols and Ethers and Oxidative Cleavage of Benzylic Tetrahydropyranyl and Trimethylsilyl Ethers to Their Carbonyl Compounds by Dinitrogen Tetroxide‐Impregnated Activated Charcoal (N2O4/Carcoal).
Authors: Iranpoor Nasser , Firouzabadi Habibi , Pourali Ali Reza
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Highly Active, Immobilized Ruthenium Catalysts for Oxidation of Alcohols to Aldehydes and Ketones. Preparation and Use in Both Batch and Flow Systems.
Authors: Kobayashi Shu , Miyamura Hiroyuki , Akiyama Ryo , Ishida Tasuku
Published: October 2005

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Convenient Fluorination of Nitro and Nitrile Compounds with Selectfluor.
Authors: Peng Weimin , Shreeve Jean'ne M.
Published: October 2005

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Gold(I)—Phosphine Catalyst for the Highly Chemoselective Dehydrogenative Silylation of Alcohols.
Authors: Ito Hajime , Takagi Katsuhiro , Miyahara Takahiro , Sawamura Masaya
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Alkynes as Synthetic Equivalents to Stabilized Wittig Reagents: Intra‐ and Intermolecular Carbonyl Olefinations Catalyzed by Ag(I), BF3, and HBF4.
Authors: Rhee Jong Uk , Krische Michael J.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Efficient One‐Step Conversion of Tetrahydropyranyl Ethers into Acetates and Formates in the Presence of Potassium Dodecatungstocobaltate K5CoW12O40×3H2O.
Authors: Rafiee E. , Tangestaninejad Sh. , Habibi M. H. , Mohammadpoor‐Baltork I. , Mirkhani V.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Photochemistry of 2‐Nitrobenzyl Enol Ethers: Oxidative C=C Bond Scission.
Authors: Yong Promise K. , Banerjee Anamitro
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Copper‐Catalyzed Stereospecific N‐Allenylations of Amides. Syntheses of Optically Enriched Chiral Allenamides.
Authors: Shen Lichun , Hsung Richard P. , Zhang Yanshi , Antoline Jennifer E. , Zhang Xuejun
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective 4‐Benzyloxybut‐2‐enylation of Aldehydes via an Allyl‐Transfer Reaction Using a Chiral Allyl Donor.
Authors: Shafi Siddiqi M. , Chou Jingyu , Kataoka Kazuhide , Nokami Junzo
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Sulfides by Reactions of 1,1‐Dichloro‐2‐chloromethylcyclopropane with S‐Nucleophiles.
Authors: Mikhed'kina E. I. , Nedel'ko P. V. , Prezhdo V. V.
Published: October 2005

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Stereoselective Synthesis of Functionalized Spiro[4.5]decanes by Claisen Rearrangement of Bicyclic Dihydropyrans.
Authors: Nakazaki Atsuo , Miyamoto Hiroshi , Henmi Kazuki , Kobayashi Susumu
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Practical Synthesis of (Z)‐Polyaromatic and Heteroaromatic Vinylacetylenes.
Authors: Hayford Anthony , Kaloko Joseph Jr. , El‐Kazaz Salwa , Bass Gwen , Harrison Cheryl , Corprew Thomas
Published: October 2005

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Directed ortho Metalation‐Based Methodology. Halo‐, Nitroso‐, and Boro‐Induced ipso‐Desilylation. Link to an in situ Suzuki Reaction.
Authors: Zhao Zhongdong , Snieckus Victor
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Preparation of Polyfunctional Arylmagnesium Reagents Bearing a Triazene Moiety. A New Carbazole Synthesis.
Authors: Liu Ching‐Yuan , Knochel Paul
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Morita—Baylis—Hillman Reaction and Cyclization of 1‐(p‐Toluenesulfonyl)‐1,3‐butadiene with Aldimines.
Authors: Back Thomas G. , Rankic Danica A. , Sorbetti Jovina M. , Wulff Jeremy E.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Catalytic Enantioselective Allylation of Ketones via a Chiral Indium(III) Complex.
Authors: Teo Yong‐Chua , Goh Joshua‐Daniel , Loh Teck‐Peng
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Direct, Pyrrolidine Sulfonamide Promoted Enantioselective Aldol Reactions of α,α‐Dialkyl Aldehydes: Synthesis of Quaternary Carbon‐Containing β‐Hydroxy Carbonyl Compounds.
Authors: Wang Wei , Li Hao , Wang Jian
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
anti‐1,2‐Diols via Ni‐Catalyzed Reductive Coupling of Alkynes and α‐Oxyaldehydes.
Authors: Luanphaisarnnont Torsak , Ndubaku Chudi O. , Jamison Timothy F.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Tetraalkylammonium and 1,3‐Dialkylimidazolium Salts with Fluorinated Anions as Recoverable Phase‐Transfer Catalysts in Solid Base Promoted Cross‐Aldol Condensations.
Authors: Kryshtal Galina V. , Zhdankina Galina M. , Zlotin Sergei G.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Achiral Ligands Dramatically Enhance Rate and Enantioselectivity in the Rh/Phosphoramidite‐Catalyzed Hydrogenation of α,β‐Disubstituted Unsaturated Acids.
Authors: Hoen Rob , Boogers Jeroen A. F. , Bernsmann Heiko , Minnaard Adriaan J. , Meetsma Auke , Tiemersma‐Wegman Theodora D. , de Vries Andre H. M. , de Vries Johannes G. , Feringa Ben L.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
A Convenient Method for the Preparations of 1‐Acylimidazoles and Carboxamides by Using Novel Imidazolylsilane Derivatives.
Authors: Tozawa Takashi , Yamane Yoshinobu , Mukaiyama Teruaki
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Alkylation of Sulfamic Esters with 4‐Fluorobenzyl Bromide
Authors: Debbabi Khaled , Beji Mohamed , Baklouti Ahmed
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Cu(OAc)2‐Catalyzed N‐Arylations of Sulfoximines with Aryl Boronic Acids.
Authors: Moessner Christian , Bolm Carsten
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
A One‐Pot Isomerization—Arylation of 2,3‐Epoxycyclohexanone under Controlled Microwave Heating.
Authors: Svennebring Andreas , Garg Neeraj , Nilsson Peter , Hallberg Anders , Larhed Mats
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
CuI/DABCO as a Highly Active Catalytic System for the Heck‐Type Reaction.
Authors: Li Jin‐Heng , Wang De‐Ping , Xie Ye‐Xiang
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Novel and Efficient Synthesis of Water‐Soluble [60]Fullerenol by Solvent‐Free Reaction
Authors: Wang Sheng , He Ping , Zhang Jian‐Min , Jiang Hu , Zhu Shi‐Zheng
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Efficient Aziridination of Olefins Catalyzed by Mixed‐Valent Dirhodium(II,III) Caprolactamate.
Authors: Catino Arthur J. , Nichols Jason M. , Forslund Raymond E. , Doyle Michael P.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Cu(I) Catalyst in DMF: An Efficient Catalytic System for the Synthesis of Furans from 2‐(1‐Alkynyl)‐2‐alken‐1‐ones.
Authors: Patil Nitin T. , Wu Huanyou , Yamamoto Yoshinori
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Novel PdII‐Mediated Cascade Carboxylative Annulation to Construct Benzo[b]furan‐3‐carboxylic Acids.
Authors: Liao Yun , Smith Jennifer , Fathi Reza , Yang Zhen
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Stereoconvergent Transformation of 1,2a‐Disubstituted 1,2,2a,8b‐Tetrahydro‐3H‐benzo[b]cyclobuta[d]pyran‐3‐ones to 1,3‐Disubstituted 1,2,4a,9b‐Tetrahydrodibenzofuran‐4‐ols and Its Application to the Second‐Generation Synthesis of (.+‐.)‐Linderol A.
Authors: Yamashita Masayuki , Inaba Tomoki , Nagahama Masaki , Shimizu Takashi , Kosaka Sachiko , Kawasaki Ikuo , Ohta Shunsaku
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Improving the Chemistry of N‐Acyliminium Ions: Nucleophilic Substitution Reactions of Pyrrolidinone Derivatives with Trialkylsilyl Nucleophiles Catalyzed by Triisopropylsilyltrifluoromethane Sulfonate (TIPSOTf).
Authors: Othman Raja Ben , Bousquet Till , Fousse Anthony , Othman Mohamed , Dalla Vincent
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
A Highly Diastereoselective Synthesis of 3‐Carbethoxy‐2,5‐disubstituted‐3‐pyrrolines by Phosphine Catalysis.
Authors: Zhu Xue‐Feng , Henry Christopher E. , Kwon Ohyun
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Synthesis of N‐Protected Pyrrolidines via Pd‐Catalyzed Reactions of γ‐(N‐Acylamino) Alkenes and γ‐(N‐Boc‐amino) Alkenes with Aryl Bromides.
Authors: Bertrand Myra Beaudoin , Wolfe John P.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Intramolecular Hydroamination of Alkynes Catalyzed by Pd(PPh3)4/Triphenylphosphine under Neutral Conditions.
Authors: Bajracharya Gan B. , Huo Zhibao , Yamamoto Yoshinori
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Construction of Quaternary Carbon Stereocenters: High Stereoselection in Mukaiyama Aldol Reactions of 2‐Siloxyindoles with Chiral Aldehydes.
Authors: Adhikari Susanta , Caille Sebastien , Hanbauer Martin , Ngo Vinh X. , Overman Larry E.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Selective Synthesis of 5‐ or 6‐Aryl Octahydrocyclopenta[b]pyrroles from a Common Precursor Through Control of Competing Pathways in a Pd‐Catalyzed Reaction.
Authors: Ney Joshua E. , Wolfe John P.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Antimicrobial and Antiinflammatory Activities of 4‐Oxothiazolidines and Their 5‐Arylidenes.
Authors: Yadav R. , Srivastava S. D. , Srivastava S. K.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Charge‐Transport in Crystalline Organic Semiconductors with Liquid Crystalline Order.
Authors: Vlachos Panos , Mansoor Bassam , Aldred Matthew P. , O'Neill Mary , Kelly Stephen M.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Facile Syntheses of 2,2‐Dimethyl‐6‐(2‐oxoalkyl)‐1,3‐dioxin‐4‐ones and the Corresponding 6‐Substituted 4‐Hydroxy‐2‐pyrones.
Authors: Katritzky Alan R. , Wang Zuoquan , Wang Mingyi , Hall C. Dennis , Suzuki Kazuyuki
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Total Synthesis and Bioactivity of Unique Flavone Desmosdumotin B and Its Analogues.
Authors: Nakagawa‐Goto Kyoko , Bastow Kenneth F. , Wu Jiu‐Hong , Tokuda Harukuni , Lee Kuo‐Hsiung
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Reactivity of 3‐Styrylchromones as Dienes in Diels—Alder Reactions under Microwave Irradiation: A New Synthesis of Xanthones.
Authors: Pinto Diana C. G. A. , Silva Artur M. S. , Brito Cristela M. , Sandulache Angela , Carrillo Jose R. , Prieto Pilar , Diaz‐Ortiz Angel , de la Hoz Antonio , Cavaleiro Jose A. S.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Binding Affinity of Novel 3‐Aminoethyl‐1‐tetralones, Potential Atypical Antipsychotics.
Authors: Alvarado Mario , Coelho Alberto , Masaguer Christian F. , Ravina Enrique , Brea Jose , Padin J. Fernando , Loza Maria I.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Synthesis of 2,6‐Disubstituted 3‐Piperidinols: Application to the Expedient Synthesis of (+)‐Julifloridine.
Authors: Lemire Alexandre , Charette Andre B.
Published: October 2005

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A Facile One‐Step Synthesis of 3‐(2‐Oxo‐2H‐chromen‐3‐yl)‐indeno[2,1‐c]pyridazin‐9‐one.
Authors: Rao V. Rajeswar , Kumar P. Vijaya
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Bismuth Oxide Perchlorate Catalyzed Efficient Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones: An Improved High Yielding Protocol for the Biginelli Reaction.
Authors: Reddy Y. Thirupathi , Reddy P. Narsimha , Kumar B. Sunil , Rao G. V. P. , Rajitha B.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
N‐Functionalization of Uracil Derivatives: Synthesis of Chiral 2‐(3‐Methyl‐5‐nitro‐2,4‐dioxo‐3,4‐dihydropyrimidin‐1(2H)‐yl)alkanoic Acids and Their Methyl Esters.
Authors: Gondela Andrzej , Walczak Krzysztof
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 6‐(3,5‐Dichlorobenzyl) Derivatives as Isosteric Analogues of the HIV Drug 6‐(3,5‐Dimethylbenzyl)‐1‐(ethoxymethyl)‐5‐isopropyluracil (GCA‐186).
Authors: Soerensen Esben R. , El‐Brollosy Nasser R. , Joergensen Per T. , Pedersen Erik B. , Nielsen Claus
Published: October 2005

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Synthesis of Optically Active Imidazo[1,2‐a]pyrimidin‐3(2H)‐ones.
Authors: Bakavoli Mehdi , Bagherzadeh Ghodsieh , Rahimizadeh Mohammad
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Selective SRPK‐1 Inhibitors: Novel Tricyclic Quinoxaline Derivatives.
Authors: Keri Gyoergy , et al. et al.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of 3H,9H,10H,10aH‐10‐Aryl‐2‐aryliminothiazolidino[4,5‐b] [1,5]benzodiazepines and Their Alkoxyphthalimide Derivatives.
Authors: Singh Bhawani , Baregama Lalit K. , Ahmed Maqbool , Dixit Neha , Talesara G. L.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Polyheterocyclic Systems: Synthesis and Biological Activity of Novel Heterocyclic Anellated Compounds from 2,3,4,5‐Tetrahydro‐1‐benzazepin‐5‐one.
Authors: Venkateswarlu Peesapati , Sunkaraneni Suresh Babu
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Diversity‐Generation from an Allenoate—Enone Coupling: Syntheses of Azepines and Pyrimidones from Common Precursors.
Authors: Evans Catherine A. , Cowen Bryan J. , Miller Scott J.
Published: October 2005

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A Convergent Approach to γ‐Carbonyl Vinyl Boronates.
Authors: Heinrich Markus R. , Sharp Lisa A. , Zard Samir Z.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Allylic Alkylation of Optically Active α‐Alkenyl‐α‐acyloxytrialkylsilane.
Authors: Sakaguchi Kazuhiko , Yamada Takeshi , Ohfune Yasufumi
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Syntheses and Spectral Characterization of 2‐Aryloxy‐5,5′‐bis(bromomethyl)‐1,3,2‐dioxaphosphorinane 2‐Oxides.
Authors: Babu M. F. Stephen , Anasuyamma U. , Venugopal M. , Raju C. Naga , Reddy C. Suresh
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Domino Hydroformylation—Wittig Olefination—Hydrogenation.
Authors: Breit Bernhard , Zahn Stephan K.
Published: October 2005

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Stereoselective Synthesis of (E)‐1‐Iodo‐1‐selenoalkenes via Hydroalumination—Iodination of 1‐Alkynyl Selenides.
Authors: Perez‐Balado Carlos , Lucaccioni Fabio , Marko Istvan E.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Hydrolysis of 3,10‐Epoxypatchenol under Mild Aqueous Conditions.
Authors: Arantes Simone Fontes , Hanson James R. , Hitchcock Peter B.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Discovery of Potent and Selective Orally Bioavailable β‐Substituted Phenylalanine Derived Dipeptidyl Peptidase IV Inhibitors.
Authors: Edmondson Scott D. , et al. et al.
Published: October 2005

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Discovery and Synthesis of a Novel and Selective Drug‐Like P2X1 Antagonist.
Authors: Jaime‐Figueroa S. , Greenhouse R. , Padilla F. , Dillon M. P. , Gever J. R. , Ford A. P. D. W.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Syntheses of 4‐Hydroxy 4‐Substituted Glutamic Acids.
Authors: Tamura Osamu , Shiro Tomoya , Ogasawara Mizuho , Toyao Atsushi , Ishibashi Hiroyuki
Published: October 2005

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Enantioselective Rhodium Enolate Protonations. A New Methodology for the Synthesis of β2‐Amino Acids.
Authors: Sibi Mukund P. , Tatamidani Hiroto , Patil Kalyani
Published: October 2005

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A Convenient, Large‐Scale Synthesis of 4′‐Carboxamido N‐Boc‐2′,6′‐dimethyl‐L‐phenylalanines.
Authors: Cai Chaozhong , Breslin Henry J. , He Wei
Published: October 2005

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Different Reaction Routes Found in Acid‐Catalyzed Glycosylation of endo‐ and exo‐Glycals: Competition Between Ferrier Rearrangement and Protonation.
Authors: Lin Hui‐Chang , Du Wen‐Ping , Chang Chih‐Chun , Lin Chun‐Hung
Published: October 2005

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Microwave‐Enhanced Synthesis of N‐Shifted Buflavine Analogues via a Suzuki—Ring‐Closing Metathesis Protocol.
Authors: Appukkuttan Prasad , Dehaen Wim , Van der Eycken Erik
Published: October 2005

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Enantioselective Synthesis of C11—C17 Segment of Mycinolide IV Using Samarium(II) Iodide‐Mediated Aldol Reaction.
Authors: Ogawa Yasuyuki , Kuroda Kiichi , Mukaiyama Teruaki
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Bond Strength of Chlorine Peroxide.
Authors: Plenge J. , Kuehl S. , Vogel B. , Mueller R. , Stroh F. , von Hobe M. , Flesch R. , Ruehl E.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis, Structure, and Acidic Properties of MCM‐41 Functionalized with Phosphate and Titanium Phosphate Groups
Authors: Kovalchuk T. V. , Sfihi H. , Korchev A. S. , Kovalenko A. S. , Il'in V. G. , Zaitsev V. N. , Fraissard J.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Self‐Assembled Highly Faceted Wurtzite‐Type ZnS Single‐Crystalline Nanotubes with Hexagonal Cross‐Sections.
Authors: Yin Long‐Wei , Bando Yoshio , Zhan Jin‐Hua , Li Mu‐Sen , Golberg Dmitri
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Nanometer‐Sized Nickel Hollow Spheres.
Authors: Liu Qi , Liu Hongjiang , Han Min , Zhu Jianmin , Liang Yongye , Xu Zheng , Song You
Published: October 2005

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Spin‐State Transition in LaCoO3 and Related Materials
Authors: Rao C. N. R. , Seikh Md. Motin , Narayana Chandrabhas
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Anhydrous Lanthanide and Actinide(III) and (IV) Orthophosphates Mm(PO4)n. Synthesis, Crystallization, Structure, and Properties
Authors: Orlova A. I. , Kitaev D. B.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Pulse Electrodeposition and Electrochemical Quartz Crystal Microbalance Techniques for High Perpendicular Magnetic Anisotropy Cobalt Nanowire Arrays
Authors: Ursache Andrei , Goldbach James T. , Russell Thomas P. , Tuominen Mark T.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Responsive Lanthanoid Luminescent Cyclen Complexes: From Switching/Sensing to Supramolecular Architectures
Authors: Gunnlaugsson Thorfinnur , Leonard Joseph P.
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Oxidative Addition of NH3 to a Transition‐Metal Complex: A Key Step for the Metal‐Mediated Derivatization of Ammonia?
Authors: Braun Thomas
Published: October 2005

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Diverse World of Unconventional Hydrogen Bonds
Authors: Belkova Natalia V. , Shubina Elena S. , Epstein Lina M.
Published: October 2005

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Recent Advances in Melatonin Receptor Ligands
Authors: Zlotos Darius P.
Published: October 2005

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Supramolecular Electronics; Nanowires from Self‐Assembled π‐Conjugated Systems
Authors: Schenning Albertus P. H. J. , Meijer E. W.
Published: October 2005

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Metal‐Containing Ionic Liquids and Ionic Liquid Crystals Based on Imidazolium Moiety
Authors: Lin Ivan J. B. , Vasam Chandra Sekhar
Published: October 2005

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Transition Metal Catalyzed Arylation of Amines and Alcohols
Authors: Zapf Alexander , Beller Matthias , Riermeier Thomas H.
Published: October 2005

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Tautomeric Equilibria and Rearrangements Involving Phenols
Authors: Lukyanov Sergei M. , Koblik Alla V.
Published: October 2005

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Hydrogen‐Bonded Complexes of Phenols
Authors: Laurence C. , Berthelot M. , Graton J.
Published: October 2005

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Manganese(III)‐Based Oxidative Free‐Radical Cyclizations
Authors: Snider Barry B.
Published: October 2005

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Cyclopropanation
Authors: Pfaltz Andreas
Published: October 2005

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Photochemistry of Aromatic Compounds
Authors: Gilbert Andrew
Published: October 2005

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Oxidation of Carbonyl Compounds
Authors: le Paih Jacques , Frison Jean‐Cedric , Bolm Carsten
Published: October 2005

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Aerobic Oxidations and Related Reactions Catalyzed by N‐Hydroxyphthalimide
Authors: Ishii Yasutaka , Sakaguchi Satoshi
Published: October 2005

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Organocatalytic Oxidation: Ketone‐Catalyzed Asymmetric Epoxidation of Olefins
Authors: Shi Yian
Published: October 2005

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Recent Developments in the Osmium‐Catalyzed Dihydroxylation of Olefins
Authors: Sundermeier Uta , Doebler Christian , Beller Matthias
Published: October 2005

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Carbometalation Reactions of Zinc Enolate Derivatives
Authors: Banon‐Tenne Daniella , Marek Ilan
Published: October 2005

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Titanium‐Mediated Reactions
Authors: Duthaler Rudolf O. , Bienewald Frank , Hafner Andreas
Published: October 2005

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Chromium(II)‐Mediated and ‐Catalyzed C—C Coupling Reactions
Authors: Hodgson David M. , Comina Paul J.
Published: October 2005

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Palladium‐Catalyzed Allylic Substitutions
Authors: Heumann Andreas
Published: October 2005

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Cyclomerization of Alkynes
Authors: Boennemann H. , Brijoux W.
Published: October 2005

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Transition Metal Catalyzed Alkene and Alkyne Hydrocyanations
Authors: Casalnuovo Albert L. , RajanBabu T. V.
Published: October 2005

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Luminescent Sensors and Switches in the Early 21st Century
Authors: Callan John F. , de Silva A. Prasanna , Magri David C.
Published: October 2005

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Cellular Profiling of Small‐Molecule Bioactivities: An Alternative Tool for Chemical Biology
Authors: Berg Thorsten
Published: October 2005

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Tailoring Porphyrins and Chlorins for Self‐Assembly in Biomimetic Artificial Antenna Systems
Authors: Balaban Teodor Silviu
Published: October 2005

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Pathogenic Factors of Vibrios with Special Emphasis on Vibrio vulnificus
Authors: Shinoda Sumio
Published: October 2005

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Bioinspired Surfaces with Special Wettability
Authors: Sun Taolei , Feng Lin , Gao Xuefeng , Jiang Lei
Published: October 2005

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Polymorphs, Regulations, Crystallization, and Solid‐State Chemistry
Authors: Byrn Stephen R. , Pfeiffer Ralph R. , Stowell Joseph G.
Published: October 2005

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Mechanism for Transduction of the Ligand‐Binding Signal in Heme‐Based Gas Sensory Proteins Revealed by Resonance Raman Spectroscopy
Authors: Uchida Takeshi , Kitagawa Teizo
Published: October 2005

For Abstract see ChemInform Abstract in Full Text.
Epidemiology of cancer‐related fatigue in the Swedish twin registry
Authors: Forlenza Michael J. , Hall Per , Lichtenstein Paul , Evengard Birgitta , Sullivan Patrick F.
Published: October 2005

BACKGROUND

Estimates of the prevalence of cancer‐related fatigue (CRF) are wide, and data suggest that fatigue is more prevalent among cancer patients than among the general population. However, most studies examining the prevalence of CRF have been hospital‐based or clinic‐based studies, which often are subject to bias.

METHODS

Point prevalence and prevalence odds ratios of fatigue were estimated using data from a large, population‐based cohort that was screened for fatigue and linked with national registry‐based data about cancer. Prevalence odds ratios and 95% confidence intervals were calculated using logistic regression with general estimating equations.

RESULTS

Approximately 23% of cancer registrants reported abnormal fatigue in the previous 6 months, 19% reported abnormal fatigue that lasted for at least 1 month, 14% reported abnormal fatigue that lasted at least 6 months, and 11% reported abnormal fatigue that lasted at least 6 months and caused significant functional impairment. Individuals who were listed in the cancer registry within the last 5 years were more likely to report experiencing fatigue than individuals who were not listed. There was an elevated prevalence of fatigue among those who were registered with carcinomas of the lung, uterine cervix, colon‐rectum, ovaries, and prostate. Both women and men who were listed recently in the cancer registry were more likely to experience any level of fatigue than the comparison group. However, a greater proportion of women experienced fatigue relative to men.

CONCLUSIONS

A greater proportion of individuals who were listed in a national cancer registry reported experiencing fatigue compared with individuals in the general population. Cancer 2005. © 2005 American Cancer Society.
Treatment of osteosarcoma at first recurrence after contemporary therapy
Authors: Chou Alexander J. , Merola Pamela R. , Wexler Leonard H. , Gorlick Richard G. , Vyas Yatin M. , Healey John H. , LaQuaglia Michael P. , Huvos Andrew G. , Meyers Paul A.
Published: October 2005

BACKGROUND

Overall survival after recurrence of osteosarcoma (OS) is < 30%. The authors reported their experience treating recurrent OS at the time of first recurrence (R1).

METHODS

Patients with high‐grade OS who achieved complete disease remission (CR) after primary surgery and chemotherapy, and patients who were treated at R1 at Memorial Sloan‐Kettering Cancer Center (New York, NY) after 1990 were analyzed by retrospective chart review.

RESULTS

For 43 eligible patients, the median time to R1 from initial diagnosis was 21.7 months (range, 4.6–135.7 mos). The lungs were the most common sites of disease recurrence (n = 33 of 43). With a median follow‐up of 15.2 months (range, 0.7–158.3 mos) after R1, 15 of 43 (35%) patients were alive. Four of 43 patients were treated with surgery alone (3 patients were alive and 1 had died of progressive disease at the time of last follow‐up). Due to unresectable disease, eight patients received only chemotherapy, none of whom survived. For patients with disease recurrence treated with chemotherapy and surgery (n = 31), 22 patients achieved a second CR (CR2). Nine patients were alive and in disease remission (29%) at the time of last follow‐up. Twenty‐three patients received ifosfamide as part of their retrieval regimen. Of the 18 who achieved a CR2, 8 experienced disease recurrence, 7 remain alive in CR2, and 3 died due to toxicity. Eight patients did not receive ifosfamide. Of these, 4 achieved a CR2 but 3 subsequently experienced disease recurrence.

CONCLUSIONS

At R1, 22 of 31 patients achieved a CR2 with aggressive surgery and chemotherapy. The majority of these patients subsequently developed a disease recurrence. Patients appeared to benefit from the addition of ifosfamide to their retrieval regimens. In the end, the role of chemotherapy in recurrent OS continues to remain undefined. Cancer 2005. © 2005 American Cancer Society.
Developing a cancer‐specific geriatric assessment
Authors: Hurria Arti , Gupta Supriya , Zauderer Marjorie , Zuckerman Enid L. , Cohen Harvey J. , Muss Hyman , Rodin Miriam , Panageas Katherine S. , Holland Jimmie C. , Saltz Leonard , Kris Mark G. , Noy Ariela , Gomez Jorge , Jakubowski Ann , Hudis Clifford , Kornblith Alice B.
Published: October 2005

BACKGROUND

As the U.S. population ages, there is an emerging need to characterize the “functional age” of older patients with cancer to tailor treatment decisions and stratify outcomes based on factors other than chronologic age. The goals of the current study were to develop a brief, but comprehensive, primarily self‐administered cancer‐specific geriatric assessment measure and to determine its feasibility as measured by 1) the percentage of patients able to complete the measure on their own, 2) the length of time to complete, and 3) patient satisfaction with the measure.

METHODS

The geriatric and oncology literature was reviewed to choose validated measures of geriatric assessment across the following domains: functional status, comorbidity, cognition, psychological status, social functioning and support, and nutritional status. Criteria applied to geriatric assessment measurements included reliability, validity, brevity, and ability to self‐administer. The measure was administered to patients with breast carcinoma, lung carcinoma, colorectal carcinoma, or lymphoma who were fluent in English and receiving chemotherapy at Memorial Sloan‐Kettering Cancer Center (New York, NY) or the University of Chicago (Chicago, IL).

RESULTS

The instrument was completed by 43 patients (mean age, 74 yrs; range, 65–87 yrs). The majority had AJCC Stage IV disease (68%). The mean time to completion of the assessment was 27 minutes (range, 8–45 mins). Most patients were able to complete the self‐administered portion of the assessment without assistance (78%) and were satisfied with the questionnaire length (90%). There was no association noted between age (P = 0.56) or educational level (P = 0.99) and the ability to complete the assessment without assistance.

CONCLUSIONS

In this cohort, this brief but comprehensive geriatric assessment could be completed by the majority of patients without assistance. Prospective trials of its generalizability, reliability, and validity are justified. Cancer 2005. © 2005 American Cancer Society.
Safety of prolonged therapy with bortezomib in relapsed or refractory multiple myeloma
Authors: Berenson James R. , Jagannath Sundar , Barlogie Bart , Siegel David T. , Alexanian Raymond , Richardson Paul G. , Irwin David , Alsina Melissa , Rajkumar S. Vincent , Srkalovic Gordon , Singhal Seema , Limentani Steven , Niesvizky Ruben , Esseltine Dixie L. , Trehu Elizabeth , Schenkein David P. , Anderson Kenneth
Published: October 2005

BACKGROUND

Bortezomib, a first‐in‐class proteasome inhibitor, is active with manageable toxicities in relapsed and/or refractory myeloma.

METHODS

Bortezomib 1.0 or 1.3 mg/m2 was administered Days 1, 4, 8, and 11 every 21 days for up to 8 cycles to patients with relapsed and/or refractory myeloma participating in two Phase II trials. Dexamethasone could be added because of progressive disease after 2 cycles or stable disease after 4 cycles. Continuation of or retreatment with bortezomib was offered to patients who, in the investigator's opinion, would benefit from extended treatment.

RESULTS

Sixty‐three patients with relapsed/refractory myeloma treated in this extension trial received a median of 7 additional cycles of therapy, for a total of 14 cycles (range, 7–32) over a median duration of therapy of 45.1 weeks in the parent and extension studies. Seventy‐eight percent of patients completed this study at the same or higher bortezomib dose than they started on during this study, and the treatment schedule of twice‐weekly administration remained unchanged in 89%. Overall, 75% of patients received dexamethasone in combination with bortezomib for a median of 5 cycles starting either in the parent or extension study. The safety profile was similar between the extension and parent trials, with no evidence of new cumulative toxicity. The most commonly reported Grade 3/4 toxicities were thrombocytopenia (29%), with a consistent pattern of recovery during the rest period of each cycle, diarrhea (11%), anemia (11%), and neutropenia (10%). Neuropathy was reported less frequently.

CONCLUSIONS

Retreatment with or continuation of bortezomib ± dexamethasone beyond 6 months was safe, and toxicities were manageable, in patients with relapsed and/or refractory myeloma. Cancer 2005. © 2005 American Cancer Society.
A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function
Authors: Jansen Catherine E. , Miaskowski Christine , Dodd Marylin , Dowling Glenna , Kramer Joel
Published: October 2005

BACKGROUND

Little is known about the effects of chemotherapy on cognitive function. The purposes of this metaanalysis were to estimate the effect sizes for the effect of chemotherapy on each domain of cognitive function and to differentiate effect sizes by each method of comparison of effects (i.e., normative data, control group, or baseline data).

METHODS

Sixteen studies that evaluated cognitive function in chemotherapy patients were included in the study. DSTAT metaanalysis software was used to calculate an effect size and confidence intervals for each neuropsychologic test. Tests were assigned to a specific cognitive domain, and an average effect size was determined for each domain.

RESULTS

Only one domain of cognitive function (i.e., visual memory) had significant chemotherapy‐induced impairment across all comparison types. However, when the neuropsychologic test scores of chemotherapy patients were compared with normative data, significant effect sizes were found for four domains of cognitive function (i.e., executive function, information processing speed, verbal memory, visual memory). In addition, significant, albeit small, effect sizes were found for language and verbal memory when chemotherapy patients' test scores were compared with test scores of healthy matched controls. All significant averaged effect sizes were in the negative direction, indicating that mean scores on neuropsychologic tests for patients who had received chemotherapy were on average lower than comparison scores.

CONCLUSION

Data from this metaanalysis supported the hypothesis that chemotherapy can have a negative impact on cognitive function. However, most deficits in this study ranged from small to moderate and were nonsignificant. Cancer 2005. © 2005 American Cancer Society.
Mononuclear and Polynuclear Chain Complexes of a Series of Multinucleating N/S Donor Ligands
Authors: Ronson Tanya K. , Adams Harry , Ward Michael D.
Published: October 2005

We have prepared a series of five ligands with potentially N,S‐bidentate chelating arms derived from 3‐[2‐(methylsulfanyl)phenyl]pyrazole linked to central aromatic spacers by methylene units. Complexes with a variety of architectures have been obtained, including simple mononuclear complexes and polynuclear chain complexes. The p‐xylyl‐spaced ligand L1 forms one‐dimensional helical coordination polymers with copper(I) and silver(I) ions. These polymers display interligand aromatic stacking interactions within each helical chain. The m‐xylyl‐spaced ligand L2 forms a coordination polymer with copper(I) but a mononuclear complex with the larger silver(I) ion in which the central phenyl ring is involved in an η1 π‐type Ag···C interaction with the AgI. The 3,3′‐biphenyl‐spaced ligand L3 also forms one‐dimensional polymers with silver(I) and copper(I) ions, but in this case the sequence of bridging ligands between one metal centre and the next follows a zig‐zag path rather than being helical. The 1,8‐naphthyl‐spaced ligand L4 only forms mononuclear complexes with copper(I) and silver(I) ions showing that this spacer is not large enough to enforce a bridging coordination mode. The three‐armed ligand L5, prepared from 2,4,6‐tris(bromomethyl)mesitylene, also forms a mononuclear complex with silver(I) ions, where one of the three arms is pendant. However, when excess silver(I) ions are present two of these mononuclear complexes can be assembled into the trinuclear complex [Ag3(L5)2](ClO4)3. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
A Highly Efficient Synthetic Protocol for Tetrahydropyranylation/Depyranylation of Alcohols and Phenols
Authors: Khan Abu T. , Ghosh Subrata , Choudhury Lokman H.
Published: October 2005

Bismuth(III) nitrate pentahydrate [Bi(NO3)3·5H2O] is found to be an effective catalyst for both tetrahydropyranylation and depyranylation of alcohols and phenols. Some of the major advantages of this protocol are: non‐aqueous workup, good yields, the involvement of a less‐expensive and nontoxic catalyst, and compatibility in the presence of a large number of other protecting groups. Notably, isopropylidene, benzylidene, and thioacetal groups are also unaffected under the experimental conditions. Remarkably, a selective mono‐protection of diols and primary alcohols can be achieved chemoselectively by employing the same catalyst. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Ultrasound preexposure improves endothelial cell binding and retention on biomaterial surfaces
Authors: Hsu Shan‐hui , Huang Tsung‐bin , Chuang Shang‐chi , Tsai I‐Jine , Chen David C.
Published: October 2005

In spite of the extensive studies regarding the effects of ultrasound on biological systems, the influence of low‐intensity ultrasound on endothelial cells has rarely been investigated. In this work, the effect of ultrasound in improving the binding between endothelial cells and biomaterial substrates was evaluated. Based on the results, low‐intensity ultrasound could change the morphology and matrix secretion of endothelial cells, and such effects persisted when preexposed cells were seeded to another substrate. The cells preexposed to ultrasound were spread further on the substrate. The actin stress fibers of ultrasound‐preexposed cells on RGD‐modified surfaces were especially intense and well oriented. Ultrasound could probably activate cellular integrins and subsequently allow RGD to bind them. A much firmer adhesion of ultrasound‐preexposed endothelial cells to the biomaterial surface coated with the RGD‐containing protein was demonstrated. Finally, polyurethane small‐diameter vascular grafts seeded with ultrasound‐preexposed endothelial cells showed enhanced cell retention on graft surfaces upon flushing. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006