bluuebunny/crossref_metadata_2025 huggingface dataset:
Kleeblattschädel skull presenting in concert with Pfeiffer syndrome
Authors: Sajid Mir Ibrahim , Malik Noor , Balouch Samira S. , Javed Gohar
Published: December 2019

Background

Kleeblattschädel skull, also known as the cloverleaf is a complex synostosis which presents with an enlarged tri-lobar skull resulting temporal bulging and a flat posterior skull, a rare find in the population. This pansynostosis is associated with other congenital syndromes which include Crouzon, Pfeifer, and Carpenter’s. The genetic disorder Pfeiffer syndrome results from skull bones’ premature fusion characterized by deformities of the hand and feet. The author reports a 10-month-old girl who presented with a tri-lobar skull and wide toes which is a significant finding of Pfeiffer syndrome.

Case presentation

A 10-month-old girl presents with congenital obstructive hydrocephalus due to cloverleaf skull with horizontally enlarged head and large fontanelles. The child also had mid-facial hypoplasia and pre-axial bilateral lower limb polydactyly. Wide toes were also observed, an indicator of Pfeiffer’s Syndrome. Computed tomography (CAT) scans grossly abnormal craniofacial appearances, with premature closure of the sagittal suture giving a cloverleaf skull appearance. There was also a significant thinning of the brain parenchyma.

Conclusion

Premature closure of sutures leads to a forced growth in a plane perpendicular to the closed suture. Cloverleaf deformity can present with multiple syndromes such as Pfeiffer’s. This leads to gross alteration of the skull with potential underlying morbidity.
Pulmonary arterial hypertension: the case for a bioelectronic treatment
Authors: Ntiloudi Despοina , Qanud Khaled , Tomaio Jacquelyn-Nicole , Giannakoulas George , Al-Abed Yousef , Zanos Stavros
Published: December 2019

Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive and vasodilative processes in the pulmonary circulation, pulmonary vasoconstriction, vascular and right ventricular remodeling, systemic inflammation, and autonomic imbalance, with a reduced parasympathetic and increased sympathetic tone. Current pharmacological treatments for PAH include several classes of drugs that target signaling pathways in vascular biology and cardiovascular physiology, but they can have severe unwanted effects and they do not typically stop the progression of the disease. Pulmonary artery denervation has been tested clinically as a method to suppress sympathetic overactivation, however it is a nonspecific and irreversible intervention. Bioelectronic medicine, in particular vagus nerve stimulation (VNS), has been used in cardiovascular disorders like arrhythmias, heart failure and arterial hypertension and could, in principle, be tested as a treatment in PAH. VNS can produce pulmonary vasodilation and renormalize right ventricular function, via activation of pulmonary and cardiac vagal fibers. It can suppress systemic inflammation, via activation of fibers that innervate the spleen. Finally, VNS can gradually restore the balance between parasympathetic and sympathetic tone by regulating autonomic reflexes. Preclinical studies support the feasibility of using VNS in PAH. However, there are challenges with such an approach, arising from the need to affect a relatively small number of relevant vagal fibers, and the potential for unwanted cardiac and noncardiac effects of VNS in this sensitive patient population.
Plasminogen activator inhibitor (PAI-1) gene polymorphism (4G/5G) and hepatocellular carcinoma in Egyptian patients
Authors: Nemr Nader , Mandour Mohamed , Badran Dahlia , Kishk Rania , Attia Fawzy , Hashish Abdullah , Gaber Ahmed
Published: December 2019

Background

Plasminogen activator inhibitor-1 (PAI-1), which is a part of urokinase plasminogen activation (uPA) system, had been reported to have a crucial role in the development of different types of cancers. The PAI-1 gene, located on chromosome 7, contains nine exons and eight introns. This gene is highly polymorphic, and its most common polymorphism (4G/5G) affects PAI-1 biosynthesis and consequently its circulating level.

Aim

The current study investigated the distribution of genotypes and the allelic frequency of the PAI-1 4G/5G polymorphism in hepatocellular carcinoma (HCC) compared to chronic HCV patients living in Egypt. Additionally, the effect of the PAI-1 4G/5G polymorphism on serum PAI-1 levels was assessed.

Methods

The study was carried on 50 HCC and 47 chronic HCV patients using real-time polymerase chain reaction.

Results

The genotypic distributions of the 4G/5G polymorphism (5G/5G, 4G/4G, 4G/5G, and 4G/4G + 4G/5G) and the frequency of alleles (5G and 4G) were not statistically significantly different between both study groups (p > 0.05). In addition, serum levels of PAI-1did not show any significant difference between HCC patients and HCV patients regarding all different genotypes of the 5G/4G polymorphism at p > 0.05 neither between the different genotypes of the 5G/4G polymorphism in the same group at p > 0.05.

Conclusion

Our study suggests that the PAI-1 4G/5G polymorphism may not be considered as one of the underlying genetic causes of hepatocarcinogenesis in chronically HCV-infected patients living in Egypt.
Prolactin Enhances the Proliferation of Proliferative Endometrial Glandular Cells and Endometrial Cancer Cells
Authors: Yamaguchi Munekage , Erdenebaatar Chimeddulam , Saito Fumitaka , Honda Ritsuo , Ohba Takashi , Kyo Satoru , Tashiro Hironori , Katabuchi Hidetaka
Published: December 2019

To elucidate the mechanism of endometrial cancer (EC) development in young hyperprolactinemic women, this study assessed the hormonal receptor expression, proliferation, and signaling induced by prolactin in endometrial glands (EG) and EC.

Prolactin receptor (PRLR) and estrogen receptor alpha (ER-α) in EG were evaluated during the menstrual cycle by immunohistochemistry. The following parameters were compared between EM-E6/E7/TERT cells, which originated from proliferative EG and Ishikawa cells. The expression levels of PRLR, pJAK2 (phosphorylated Janus Activating Kinase 2), its downstream pathways (MAPK, PI3K, and STAT), and ER-α were assessed after adding prolactin by Western blotting. U0126 was used as a MAPK inhibitor. The proliferation caused by estradiol was also examined by MTS assay after adding prolactin.

PRLR expression in the EG was significantly higher in the proliferative phase than in the secretory phase, and it was correlated with ER-α expression during the menstrual cycle. After adding prolactin, the expression of pJAK2, PRLR and ER-α was significantly increased in both cell lines, MAPK was activated after adding prolactin in both cell lines, and PI3K and STAT were activated only in EM-E6/E7/TERT cells. The increased proliferation induced by estradiol was enhanced after adding prolactin in both cell lines. All changes caused by prolactin were inhibited in Ishikawa cells pretreated with U0126.

Long-term effects of serum prolactin on persistent proliferative endometrium in the presence of estradiol may induce abnormal proliferation of EG in hyperprolactinemic women. Prolactin-PRLR signaling via MAPK may play a crucial role in the progression of EC in hyperprolactinemic women.
The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes
Authors: Nguyen Thi Minh Xuan , Vegrichtova Marketa , Tlapakova Tereza , Krulova Magdalena , Krylov Vladimir
Published: December 2019

Sertoli cells (SCs) play a central role in the determination of male sex during embryogenesis and spermatogenesis in adulthood. The failure in SC development is responsible for a male sterility and testicular cancer. Before the onset of puberty, SCs are immature and differ considerably from mature cells in post-pubertal individuals regarding their morphology and biochemical activity. The major intermediate filament (IF) in mature SCs is vimentin anchoring germ cells to seminiferous epithelium. The collapse of vimentin has resulted in the disintegration of seminiferous epithelium and subsequent germ cell apoptosis. However, another IF, cytokeratin (CK) is observed only transiently in immature SCs in many species. Nevertheless, its function in SC differentiation is poorly understood. We examined the interconnection between CK and cell junctions using membrane β-catenin as a marker during the testicular development regarding Xenopus tropicalis model. Immunohistochemistry on juvenile (5-months-old) testes revealed co-expression of cytokeratin, membrane β-catenin and E-cadherin. Adult (3 years old males) samples confirmed only E-cadherin expression but cytokeratin and β-catenin was lost. To study the interconnection between CK and β-catenin-based cell junctions, the culture of immature SCs, here called XtiSCs was employed. Suppression of CK by acrylamide in XtiSCs led to breakdown of membrane-bound β-catenin but not F-actin and β-tubulin or cell adhesion proteins (Focal adhesion kinase and integrin β1). In contrast to the obvious dependence of membrane β-catenin on CK stability, the detachment of β-catenin from the plasma membrane via uncoupling of cadherins by Ca2+ chelator EGTA had no effect on the CK integrity. Interestingly, CHIR99021, a GSK3 inhibitor, also suppressed CK network resulting in the inhibition of XtiSCs cell-to-cell contacts and testicular development in juvenile frogs. This study suggests a novel role of CK in the retention of β-catenin-based junctions in immature SCs, and thus provides structural support for the seminiferous tubule formation and germ cell development.
Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila
Authors: Katsube Hiroka , Hinami Yukiko , Yamazoe Tatsuki , Inoue Yoshihiro H.
Published: December 2019

The destruction of pancreatic β cells leads to reduced insulin secretion and eventually causes. Various types of cellular stress are thought to be involved in destruction and/or malfunction of these cells. We show that endoplasmic reticulum (ER) stress accumulation in insulin-producing cells (IPCs) generated diabetes-like phenotypes in Drosophila. To promote the accumulation of extra ER stress, we induced a dominant-negative form of a Drosophila ER chaperone protein (Hsc70-3DN) and demonstrate that it causes the unfolded-protein response (UPR) in various tissues. The numbers of IPCs decreased owing to apoptosis induction mediated by caspases. The apoptosis was driven by activation of Dronc, and subsequently by Drice and Dcp-1. Accordingly, the relative mRNA-expression levels of Drosophila insulin-like peptides significantly decreased. Consistent with these results, we demonstrate that glucose levels in larval haemolymph were significantly higher than those of controls. Accumulation of ER stress induced by continuous Hsc70-3DN expression in IPCs resulted in the production of undersized flies. Ectopic expression of Hsc70-3DN can induce more efficient ER stress responses and more severe phenotypes. We propose that ER stress is responsible for IPC loss and dysfunction, which results in diabetes-related pathogenesis in this Drosophila diabetes model. Moreover, inhibiting apoptosis partially prevents the ER stress-induced diabetes-like phenotypes.
Post-therapeutic lymphedema in breast cancer
Authors: RACHERIU Mihaela , SILIȘTEANU Sînziana Călina , COCA Maria Ramona
Published: December 2019

Introductions. Lymphedema is an interstitial accumulation of protein-rich lymph fluid, due to the post-therapeutic alteration of lymphatic circulation in the upper limb. The appearance of lymphedema is favoured by a number of risk factors. All of these factors ultimately lead to a process of tissue fibrosis. Materials and methods. This study was carried out in an outpatient regimen, for a period of 12 months, in the kinetotherapy room, using massage elements for lymphatic drainage and kinetotherapy technique. The study group included 15 patients aged 27-65 years.Results and discutions. Patients evaluated the quality of life after surgery based on the physical and mental symptoms, which is why anxiety, pain reduction through massage and kinetotherapy give patients self-confidence as well as confidence in the recovery process. Conclusions. This complex programme that includes lymphatic drainage massage methods and kinetotherapy techniques should be applied individually, progressively, under the control of the kinetotherapist. Key words: lymphedema, kinetotherapy technique, lymphatic drainage massage,
Self-defence techniques and procedures, adapted for paraplegic persons independent in wheelchair, to counteract hetero-aggressive behavior
Authors: SERBAN Diana-Elena , ANGHELESCU Aurelian , CONSTANTIN Elena , ONOSE Gelu
Published: December 2019

Introduction. Persons living in wheelchair are often target of hetero-aggressive behavior. The aggressors perceive persons in wheelchair as easy victims.
Obiectives Acquisition of adapted self-defense techniques and procedures by young paraplegic persons, independed in wheelchair, to counteract some possible hetero-aggressive behavior against them.
Material and methods. A young male person, former sportsman (familiarised with wrestling techniques), living with T11 AIS-A (complete) paraplegia after a spinal cord injury and independent in wheelchair,
was instructed some various taekwondo techniques and maneuvres: blocking an attack with the hand at the head region (Olgul Jireugi), hand block (Olgul Maki), hand counteratack (Momntong Jireugi), foot attack at the head region (Olgul Dollyo Chagi), hand block (Sonnal Olgul Maki), hand counterattack (Arae Jireugi).
The young female who plays the role of attacker has black belt in taekwondo, therefore the maneuvres were performed in total safety, without endangering the pacient.
Both protagonists of this presentation have given written consent to be photographed and filmed, for academic purpose. The paper has the approval of the Ethics Committee of “Bagdasar-Arseni” Clinical Emergency Hospital, n.o. 17464/14.06.2019.
Results: We realized photographs and films depicting the aforementioned taekwondo techniques, to demonstrate some possible scenarios of aggression.
Discussion Acquisition of martial art techniques and procedures by paraplegic people, independent in wheelchair, is essential and may improve their safety, participation, self-esteem and quality of life.
Conclusions: Prevention, as a self defense method, is essential. The best way is to avoid conflictual situations, but ideal is to be prepared for any situation.

Key words: paraplegia, spinal cord injury seqelae, taekwondo, self defense techniques, participation, quality of life,
Whole issue
Authors: Εταιρεία Ελληνική Κτηνιατρική
Published: December 2019

NO ABSTRACT AVAILABLE
Effect of Ferula communis L. on reproductive parameters in Awassi ewes
Authors: ONAL A.G.
Published: December 2019

Nutrient composition of the diet affects follicular activity, embryonic development and reproductive hormones in ruminants. The objective of the present study was to investigate the effects of Ferula communis L. on some reproductive parameters of Awassi sheep. The experiment was carried out on 29 (15-16 months old) Awassi ewes. All ewes were allocated to receive either a control (14% CP and 11.7 MJ ME/kg, n=9) or a diet supplemented with 5% (75g, n=10) or 10% (150g, n=10) powdered F. communis root, respectively for 21 days. Oestrus was synchronized using intravaginal sponges, while oestrus behaviour was observed 24, 36 and 48h after the sponge removal. Blood samples were collected for the assessment of oestradiol and LH. At the end of the 21-day period, animals were slaughtered and ovarian structures were recorded. Corpora lutea tissues were cultured in vitro, and progesterone production was measured. The results indicate that the treatment of animals with 5% of F. communis root increased the percentage of animals in heat (80%, 60% and 10% for 5C, 10C, and the control group, respectively). Furthermore, the number of small follicles (1-3 mm) in treated groups was significantly higher than those of the control group. Moreover, the number of large follicles (>4 mm) in the control group was higher than those of the treatment groups. Plasma concentration of oestrogen and LH peak were similar in the control and treatment groups. Progesterone production by luteal cells cultured in vitro was higher for both treatment groups compared to the control. Herewith, supplementation of the diet of Awassi Sheep with F. communis root during the breeding season may enhance ovulation rate and luteal activity.
Expression of micro-RNAs miR-31, miR-146a, miR-181c and miR-155 and their target gene IL-2 are altered in schizophrenia: a case-control study
Authors: Ghazaryan Hovsep , Zakharyan Roksana , Petrek Martin , Navratilova Zdenka , Chavushyan Andranik , Novosadova Eva , Arakelyan Arsen
Published: December 2019

Background:Schizophrenia is a severe psychiatric disorder with a heterogeneous clinical phenotype. The association of interleukins and other cytokines and their receptors with schizophrenia has been previously reported. Additionally, a number of studies have reported altered mico-RNA (miRNA) expression in schizophrenia and other psychiatric disorders. The aim of our study was to explore the possible association of miR-31, miR-146a, miR-181c and miR-155 with schizophrenia pathogenesis, as well as their link toIL2gene expression in disease.

Methods: For this case-control study, 225 patients with paranoid schizophrenia and 225 sex- and age-matched controls with no family history of schizophrenia were recruited. The expression of studied miRNAs and theIL2gene was measured using qPCR. DNA samples of all patients and controls were genotyped forIL2rs2069778 single nucleotide polymorphism (SNP) using PCR with sequence specific primers (PCR-SSP). Statistical analyses include the Mann-Whitney U-test and Fischer’s exact test.

Results: All studied miRNAs were over-expressed in schizophrenic patientsIL2gene expression was down-regulated in schizophrenic patients. TheIL2rs2069778 SNP is not associated with schizophrenia but regulates expression of theIL2 gene.

Conclusions: Over-expression of studied miRNAs and down-regulation ofIL2gene expression may be considered as genetic risk factors for chronic schizophrenia. Abnormalities in studied miRNA expressions result in the deregulation of the T-cell receptor signaling pathway in schizophrenia.
PYLFIRE: Python implementation of likelihood-free inference by ratio estimation
Authors: Kokko Jan , Remes Ulpu , Thomas Owen , Pesonen Henri , Corander Jukka
Published: December 2019

Likelihood-free inference for simulator-based models is an emerging methodological branch of statistics which has attracted considerable attention in applications across diverse fields such as population genetics, astronomy and economics. Recently, the power of statistical classifiers has been harnessed in likelihood-free inference to obtain either point estimates or even posterior distributions of model parameters. Here we introduce PYLFIRE, an open-source Python implementation of the inference method LFIRE (likelihood-free inference by ratio estimation) that uses penalised logistic regression. PYLFIRE is made available as part of the general ELFI inference software http://elfi.ai to benefit both the user and developer communities for likelihood-free inference.
Gonadal development of the holothurian Holothuria polii (Delle Chiaje, 1823) in spawning period at the Aegean Sea (Mediterranean Sea)
Authors: Tolon Mustafa Tolga , Engin Serhat
Published: December 2019

The Mediterranean sea cucumbers including Holothuria polii has become commercially important in international trade due to the high demand of consumers from Far East countries. Sea cucumbers fisheries is a valuable income for the regional fishermen but natural stocks endangered by overfishing in recent years. Fisheries regulations and aquaculture studies are important precautions for preserving natural stocks. All these efforts are based on reproduction biology of this species which slightly differed among regions. In this study, the reproduction biology including morphological characteristics, gonadosomatic index and gonadal development stages of H.polii at the eastern coast of Aegean Sea (Izmir, Turkey) were investigated during the reproduction (spawning) period from July to October 2018. Gonads and gonad sections of 60 sea cucumbers (120.60 ± 19.56 g) have been observed by macroscopic and microscopic inspections. Three gonadal development stages have been identified by histologic observations as mature (III), spawning (IV) and post-spawning stage (V) in gonadal tubules. Results indicate that both female and male gonads are at mature and spawning stage in July and all gonads are at post-spawning stage in October. The mean gonad weight was 12.53 ± 1.33 g at the beginning of the spawning period (July) and 1.87 ± 0.58 g at the end of the spawning period (October). Gonadosomatic index decreased from 17.53 ± 0.02% (July) to 3.37 ± 0.01% (October) after spawning. The gonadosomatic index, gonad weight, and spawning were related to the seawater temperature. According to this study, the spawning period of H.polii at the eastern coasts of the Aegean Sea starts in July and completely ends in October. As a result, the data related to the reproduction biology in spawning period of H.polii would guide stock management and artificial breeding of this species under controlled conditions.
ЛОГИСТИЧЕСКАЯ РЕГРЕССИОННАЯ МОДЕЛЬ КАК ДОПОЛНИТЕЛЬНЫЙ МАТЕМАТИЧЕСКИЙ МЕТОД ПРОГНОЗИРОВАНИЯ РАЗВИТИЯ ИЗОЛИРОВАННОЙ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ
Authors: Aksyutina Natalya Valeryevna , Shulman Vladimir Abramovich , Aldanova Elena Evgenevna , Pelipeckaya Elena Yurievna , Petrov Sergey Sergeevich , Kozlov Vasily Vladimirovich , Stepanov Nikolay Andreevich
Published: December 2019

Изучив ассоциацию генотипа ТТ и аллеля Т с развитием изолированной фибрилляции предсердий (ФП) и построив логистическую регрессионную модель, выявлено, что доля вероятности возникновения изолированной ФП при наличии генотипа ТТ составляет 6,2%; для отсутствия изолированной ФП – 95,1%. Модель предсказывает развитие изолированной ФП с чувствительностью 17,7%. Общий процент корректных предсказаний – 65,4%.Цель. Изучить прогнозирование вероятности возникновения изолированной ФП в зависимости от предикторного генотипа полиморфизма rs2200733 хромосомы 4q25 с помощью метода множественной логистической регрессии и определить меру статистически значимого влияния предикторного генотипа на развитие патологии.Материалы и методы. Обследовано 247 пациентов с ФП (113 с изолированной и 134 со вторичной). Контрольная группа представлена 182 здоровыми людьми. Всем проводился определенный спектр функциональных и лабораторных методов исследования, в том числе молекулярно-генетическое. Для прогнозирования развития изолированной ФП использовался метод логистического регрессионного анализа.Результаты. Согласно отношению шансов, наличие генотипа ТТ увеличивает риск развития ФП в 1,8 раза (при наличии аллеля Т риск развития изолированной ФП возрастает в 2,0 раза), построена логистическая регрессионная модель. Коэффициент детерминации модели R2=0,062. Специфичность модели в плане предсказывания отсутствия изолированной формы ФП – 95,1%. Модель предсказывает развитие изолированной формы ФП с чувствительностью 17,7%. Общий процент корректных предсказаний – 65,4%.Заключение. Согласно логистической регрессионной модели, доля вероятности возникновения изолированной ФП при наличии у пациента генотипа ТТ – 6,2%; для отсутствия изолированной ФП – 95,1%. Общий процент корректных предсказаний – 65,4%.
ПОКАЗАТЕЛИ ХЕМИЛЮМИНЕСЦЕНТНОЙ АКТИВНОСТИ НЕЙТРОФИЛЬНЫХ ГРАНУЛОЦИТОВ ПРИ HELICOBACTER PYLORI, АССОЦИИРОВАННОМ РАКЕ ЖЕЛУДКА
Authors: Smirnova Olga Valentinovna , Tsukanov Vladislav Vladimirovich , Sinyakov Alexander Alexandrovich , Moskalenko Olga Leonidovna , Elmanova Nina Georgievna , Ovcharenko Elizaveta Sergeevna , Kasparova Irina Eduardovna
Published: December 2019

Одной из ведущих и нерешенных проблем в медицине является рак желудка (РЖ). Риск появления РЖ у инфицированных H. pylori пациентов в 2–4 раза превышает показатели у неинфицированных больных. Роль клеток иммунной системы в трансформации хронического атрофического гастрита в РЖ бесспорна, при этом первыми клетками, реагирующими на чужеродный антиген, являются нейтрофильные гранулоциты (НГ). Целью нашей работы явилось изучение хемилюминесцентной активности нейтрофильных гранулоцитов при Helicobacter pylori, аcсоциированном раке желудка.Проведено обследование 50 пациентов с хроническим атрофическим гастритом (ХАГ) и 50 больных раком желудка (РЖ). Контрольной группой служили 85 практически здоровых донора. Оценка спонтанной и индуцированной хемилюминесценции (ХЛ) осуществляли в течение 90 минут на 36-канальном хемилюминесцентном анализаторе “CL 3606” (Россия). Определяли следующие показатели: время выхода кривой на максимум интенсивности ХЛ, максимальное значение интенсивности ХЛ, площадь под кривой ХЛ. В качестве усилителя использовали люминол. Индуктором респираторного взрыва служил опсонизированный зимозан. Усиление ХЛ, индуцированной опсонизированным зимозаном, оценивали по соотношению площади индуцированной к площади спонтанной ХЛ и обозначали индексом активации. Статистическая обработка данных проводилась с помощью пакетов прикладных программ Statistica for Windows 8.0. Критический уровень значимости при проверки статистических гипотез принимался равным р<0,05.У больных РЖ выявляется снижение максимальной интенсивности при спонтанной и индуцированной ХЛ НГ, что указывает на снижение функциональной активности клеток при злокачественном заболевании. У больных РЖ регистрируется снижение времени выхода на максимум при спонтанной и индуцированной ХЛ НГ, что свидетельствует о нарушении процесса активации нейтрофилов. У больных РЖ возрастает площадь под кривой при спонтанной и индуцированной ХЛ, выявляется большая наработка при респираторном взрыве активных форм кислорода при низкой активности самих клеток. Наиболее значимые изменения показателей хемилюминесцентной активности НГ выявлены при РЖ на III стадии, что вероятно, свидетельствует об истощение активности клеток иммунной системы и прогрессировании заболевания.Проект «Разработка и внедрение программного комплекса скрининга и ранней диагностики рака желудка по показателям иммунной, прооксидантной и антиоксидантной систем для снижения показателей смертности и инвалидизации населения» проведен при поддержке Красноярского краевого фонда науки».
ОРТОСТАТИЧЕСКАЯ ГИПОТЕНЗИЯ В ПСИХИАТРИИ (ОБЗОР ЛИТЕРАТУРЫ С КОММЕНТАРИЯМИ)
Authors: Bekker Roman Aleksandrovich , Bykov Yuriy Vitalevich
Published: December 2019

Цель исследования. Представить читателю подробный обзор касательно эпидемиологии, факторов риска, этиологических причин и патогенетических механизмов развития ортостатической гипотензии в психиатрии. Показать, каким образом ортостатическая гипотензия в психиатрии может быть источником дополнительных психических проблем, или причиной развития резистентности к проводимому психотропному лечению. Представить несколько интересных клинических случаев ортостатической гипотензии в психиатрии, включая наш собственный.Методология проведения работы. Мы провели поиск в поисковых системах PubMed, Google Scholar, Science Direct, Web of Science с использованием ключевых слов «orthostatic hypotension» в сочетании с наименованиями различных психических патологий и психотропных препаратов. Найденные поиском статьи были проанализированы нами на предмет релевантности по отношению к тематике планируемой статьи. Затем мы представили результаты этого анализа в настоящем обзоре.Результаты. В процессе составления настоящего обзора нами найдены литературные данные, убедительно свидетельствующие о том, что ортостатическая гипотензия в психиатрии является не просто «ещё одним побочным эффектом», но нередким источником таких дополнительных психических проблем, как депрессия, тревога, патологическая сонливость, ухудшение когнитивного функционирования пациентов, усиление экстрапирамидных побочных эффектов терапии. Кроме того, найденные нами литературные данные свидетельствуют также о том, что ортостатическая гипотензия в психиатрии может также быть одной из причин резистентности к проводимой терапии.Нами также найдены литературные данные о факторах риска развития ортостатической гипотензии в психиатрии. Эти данные позволяют стратифицировать пациентов по группам риска, и заранее предпринять соответствующие меры по профилактике или минимизации риска возникновения этого осложнения в уязвимых группах. Затем нами представлены клинические случаи, иллюстрирующие вышеуказанные тезисы, в том числе один случай из нашей собственной практики.Область применения результатов. Полученные нами результаты свидетельствуют о том, что проблему ортостатической гипотензии в психиатрии ни в коем случае нельзя игнорировать или недооценивать. Она заслуживает своевременного и проактивного выявления и энергичной коррекции. Это связано с тем, что ортостатическая гипотензия не только снижает качество жизни пациента и его комплаентность к лечению, но и служит источником дополнительных психических проблем, таких, как депрессия, тревога, когнитивные нарушения, чрезмерная сонливость. Она даже может быть причиной резистентности к психотропной терапии.
РАСПРОСТРАНЕННОСТЬ АКУШЕРСКО-ГИНЕКОЛОГИЧЕСКИХ ФАКТОРОВ РИСКА И ИХ ВЛИЯНИЕ НА НЕБЛАГОПРИЯТНЫЕ ИСХОДЫ БЕРЕМЕННОСТИ
Authors: Kurbanismailov Renat Badrudinovich , Narkevich Artem Nikolaevich , Vinogradov Konstantin Anatolyevich , Mironova Alena Andreevna
Published: December 2019

Цель. Изучение распространенности акушерско-гинекологических факторов и их влияния на риск развития неблагоприятных исходов беременности в Красноярском крае.Материалы и методы. Использованы данные перинатального мониторинга Красноярского края, функционирующего на базе Красноярского краевого медицинского информационно-аналитического центра. В анализ включены данные о 122 250 случаях беременности в период с 2014 по 2017 гг. Все анализируемые случаи беременности распределены на 2 группы: I группа – случаи беременности с неблагоприятными исходами (8 290 случаев), II группа – случаи беременности с благоприятными исходами (113 960 случаев). Проанализировано влияние на развитие неблагоприятных исходов беременности следующих факторов: число родов и абортов в анамнезе, наличие преждевременных родов, мертворождаемости, смерти новорожденного в неонатальном периоде в анамнезе, наличие пороков развития матки, хронических воспалительных заболеваний, опухоли яичников, миомы и рубцов матки, анемии легкой, средней и тяжелой степени тяжести, а также наличие в анамнезе экстракорпорального оплодотворения.Результаты. Результаты проведенного исследования свидетельствуют о том, что все изученные факторы оказывают влияния на риск развития неблагоприятных исходов беременности. В наибольшей степени на данный риск оказывают влияние наличие двух и более преждевременных родов в анамнезе, пороков развития матки и мертворождения в анамнезе.Заключение. Использование информации о распространенности и влиянии различных факторов на риск развития неблагоприятных исходов беременности позволит наиболее эффективно осуществлять маршрутизацию беременных по уровням оказания медицинской помощи для снижения числа данных исходов. Полученные результаты свидетельствуют о том, что на риск развития неблагоприятных исходов беременности оказывает влияние довольно широкий спектр факторов. При этом каждый фактор оказывает различное по степени влияние на данный риск.
The Hamlet First Quarto (1603) & the Play of Typography
Authors: Boeckeler Erika Mary
Published: December 2019

I argue that the First Quarto of Hamlet (1603)expresses a more intense sensitivity to polysemous typography than has been critically articulated. The orthography, typography, and layout functioned as rich sources of meaning-making for early modern readers, poets, and publishers. Performances happened on the playtext page that were often unavailable in a live theatrical setting. This article makes a crucial critical intervention in recuperating the poetic value of Q1, a text that has historically generated interest mostly within analytical bibliography, performance studies, and character studies. Readers were sensitive to how visual wordplay activated important themes to which my critical analysis attends.
‘By consent of the whole chapter’: Lincoln Cathedral’s Rewards for Touring Players and School Comedies, 1561-1593
Authors: Burg Jason
Published: December 2019

The records of Lincoln Cathedral possess the largest and most enduring evidence for cathedral-funded dramatic performance in medieval and early modern England. In the mid-sixteenth century earlier forms of financial backing were replaced by the rewarding of travelling players by the chapter. The absence of similar rewards in the civic accounts of the period makes the cathedral records unique in their documentation of touring players and school comedies in the city. The following essay demonstrates the unique role played by Lincoln Cathedral and reveals an alternative view of looking at who bestowed financial gifts on travelling players during the reign of Elizabeth I.
Review: Kevin Curran, Shakespeare’s Legal Ecologies: Law and Distributed Selfhood.
Authors: Dunne Derek
Published: December 2019

This review considers Kevin Curran's Shakespeare's Legal Ecologies: Law and Distributed Selfhood (2017).
The Impact of a Network Split on Cascading Failure Processes
Authors: Sloothaak Fiona , Borst Sem , Zwart Bert
Published: December 2019

Cascading failure models are typically used to capture the phenomenon where failures possibly trigger further failures in succession, causing knock-on effects. In many networks, this ultimately leads to a disintegrated network where the failure propagation continues independently across the various components. In order to gain insight into the impact of network splitting on cascading failure processes, we extend a well-established cascading failure model for which the number of failures obeys a power-law distribution. We assume that a single line failure immediately splits the network in two components and examine its effect on the power-law exponent. The results provide valuable qualitative insights that are crucial first steps toward understanding more complex network splitting scenarios.
Regresi Data Panel untuk Mengetahui Faktor-Faktor yang Mempengaruhi PDRB di Provinsi DIY Tahun 2011-2015
Authors: Nandita Dea Aulia , Alamsyah Lalu Bayu , Jati Enggar Prima , Widodo Edy
Published: December 2019

Population growth can encourage and hinder economic growth. This study aims to analyze the factors that influence gross domestic product (GDP) in Daerah Istimewa Yogyakarta (DIY) using panel data regression. This study uses three independent variables, namely number of population, number of poor population, and investment, while the dependent variable is GDP. We use secondary data obtained from Badan Pusat Statistik (BPS). The results obtained from the regression analysis of the data series time panel are generalized least square (GLS), while for the cross section data panel shows the REM model is more suitable than PLS and FEM. Based on the validity test of the influence or t-test, the variable that shows significant to the economic rate which is categorized as GRDP in the Daerah Istimewa Yogyakarta in 2011-2015 is the variable Total population and Investment which has a positive relationship.

Keywords : economic growth rate, panel data regression, gross regional domestic product
Peramalan Tingkat Penghunian Tempat Tidur Hotel Bintang Tiga Kota Surakarta Menggunakan Metode Autoregressive Integrated Moving Average (ARIMA)
Authors: Pratiwi Shindy Dwi
Published: December 2019

Surakarta is a cultural city that is now starting to attract domestic and foreign tourists. This makes many tourists visit the city of Surakarta so that it affects the occupancy rate of hotels in Surakarta. The occupancy rate of hotels in Surakarta has fluctuations from each year. The uncertainty of hotel occupancy rates in Surakarta will certainly affect investors to choose policies in the hotel industry so that hotel occupancy rates in Surakarta City need to be estimated for the next year. In this study, the Autoregressive Integrated Moving Average (ARIMA) method was used to forecast hotel occupancy rates in Surakarta from January to May 2018. By using the best model IMA (1.1), it was concluded that the occupancy rate of three-star Surakarta hotels increased every the month.

Keywords : occupancy rate of hotel, forecasting, ARIMA.
YouTube advertising: Exploring its effectiveness
Authors: Djafarova Elmira , Kramer Kristina
Published: December 2019

Advertising on YouTube is becoming increasingly popular due to its large potential in engaging existing and new target audiences via highly interactive video advertisements. However, YouTube is criticised for providing mostly lower value user-generated content. This leads to major concerns
among marketers regarding how resources can be allocated most efficiently across channels and how effective YouTube is as an advertising channel. The purpose of this study is to evaluate existing literature exploring the effectiveness of YouTube advertising. This research contributes to academic
literature by compiling a set of measures to assess advertising effectiveness and identifying factors affecting it in the context of online video advertising. In order to identify relevant criteria and frameworks for evaluating advertising effectiveness in the context of YouTube video advertising,
the characteristics of social media and online video advertising were analysed and the theoretical foundations of online advertising were established.
Ultraviolet trifrequency Rayleigh DWL for stratosphere atmospheric wind measurements during the daytime based on an ultranarrow-bandwidth optical receiver
Authors: Han Fei , Han Yuli , Sun Dongsong , Hu Mingyong , Liu Hengjia , Zhou Anran , Zhang Nannan , Jiang Shan , Chu Jiaqi , Zheng Jun , Lan Jiaxin
Published: December 2019

An ultranarrow-bandwidth-optical-receiver-based ultraviolet trifrequency Rayleigh Doppler wind lidar (DWL) technology is proposed that is able to simultaneously detect stratospheric wind with high precision during the daytime. The lidar system is designed, and the principle of wind measurement is analyzed. An ultranarrow-bandwidth element used for suppressing strong background light is designed as an important part of the ultranarrow-bandwidth optical receiver. A three-channel Fabry–Perot interferometer (FPI) is capable of measuring wind speed. A non-polarized beam splitter cube optically contacted on the three-channel FPI can offer a stable splitting ratio. The parameters of the three-channel FPI are optimized. The structure and parameters of the ultranarrow-bandwidth element are designed, and the transmission curve is measured. The transmission curve and stability of the three-channel FPI are validated. The background photon number is collected with the ultranarrow-bandwidth element and with an interference filter (IF) alternately from 08:00 to 18:00. Based on the selected system parameters and measured background photon number, the detection performance of the proposed lidar is simulated. Simulation results show that with 200 m range resolution from 15 to 25 km, 500 m range resolution from 25 to 40 km, and 30 min total accumulation time for paired line-of-sight (LOS) measurement, within

±

100

m

/

s

LOS wind speed range, the daytime LOS wind speed error is below 4.77 m/s from 15 to 40 km altitude. Compared with the traditional IF-based dual-FPI Rayleigh Doppler lidar, the wind speed accuracies are improved by 1.29–16.29 times and the detection altitudes are improved from 23.55 to 40 km with the same wind-detecting precision.
Dual-channel mobile fluorescence lidar system for detection of tryptophan
Authors: Chen Siying , Chen Yuanyuan , Zhang Yinchao , Guo Pan , Wu Huiyun , Li Xin , Chen He
Published: December 2019

We present a dual-channel mobile lidar system based on laser-induced fluorescence (LIF) for real-time standoff detection and concentration distribution analysis of tryptophan. The system employs an ultraviolet laser excitation source and signal detectors for receiving fluorescence signals within two different wavelength bands. The performed experiments measured tryptophan aerosols at two different standoff distances. Moreover, distilled water and ethanol solutions were also detected for comparison. The results show that the system can detect LIF signals of tryptophan, give early warnings, locate the diffusion sources, and monitor the variation of the aerosol concentration distribution in real time.
Counter-propagating photon pair generation in a nonlinear waveguide
Authors: Luo Kai-Hong , Ansari Vahid , Massaro Marcello , Santandrea Matteo , Eigner Christof , Ricken Raimund , Herrmann Harald , Silberhorn Christine
Published: December 2019

Counter-propagating parametric conversion processes in non-linear bulk crystals have been shown to feature unique properties for efficient narrowband frequency conversion. In quantum optics, the generation of photon pairs with a counter-propagating parametric down-conversion process (PDC) in a waveguide, where signal and idler photons propagate in opposite directions, offers unique material-independent engineering capabilities. However, realizing counter-propagating PDC necessitates quasi-phase-matching (QPM) with extremely short poling periods. Here, we report on the generation of counter-propagating single-photon pairs in a self-made periodically poled lithium niobate waveguide with a poling period on the same order of magnitude as the generated wavelength. The single photons of the biphoton state bridge GHz and THz bandwidths with a separable joint temporal-spectral behavior. Furthermore, they allow the direct observation of the temporal envelope of heralded single photons with state-of-the art photon counters.
Laser-induced spatially-selective tailoring of high-index dielectric metasurfaces
Authors: Berzinš Jonas , Indrišiūnas Simonas , Fasold Stefan , Steinert Michael , Žukovskaja Olga , Cialla-May Dana , Gečys Paulius , Bäumer Stefan M. B. , Pertsch Thomas , Setzpfandt Frank
Published: December 2019

Optically resonant high-index dielectric metasurfaces featuring Mie-type electric and magnetic resonances are usually fabricated by means of planar technologies, which limit the degrees of freedom in tunability and scalability of the fabricated systems. Therefore, we propose a complimentary post-processing technique based on ultrashort (≤ 10 ps) laser pulses. The process involves thermal effects: crystallization and reshaping, while the heat is localized by a high-precision positioning of the focused laser beam. Moreover, for the first time, the resonant behavior of dielectric metasurface elements is exploited to engineer a specific absorption profile, which leads to a spatially-selective heating and a customized modification. Such technique has the potential to reduce the complexity in the fabrication of non-uniform metasurface-based optical elements. Two distinct cases, a spatial pixelation of a large-scale metasurface and a height modification of metasurface elements, are explicitly demonstrated.
In Vitro Conversion Assays Diagnostic for Neurodegenerative Proteinopathies
Authors: Singh Serena , DeMarco Mari L
Published: December 2019

Background

In vitro conversion assays, including real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA) techniques, were first developed to study the conversion process of the prion protein to its misfolded, disease-associated conformation. The intrinsic property of prion proteins to propagate their misfolded structure was later exploited to detect subfemtogram quantities of the misfolded protein present in tissues and fluids from humans and animals with transmissible spongiform encephalopathies. Currently, conversion assays are used clinically as sensitive and specific diagnostic tools for antemortem diagnosis of prion disease.

Content

In vitro conversion assays are now being applied to the development of diagnostics for related neurodegenerative diseases, including detection of misfolded α-synuclein in Parkinson disease, misfolded amyloid-β in Alzheimer disease, and misfolded tau in Pick disease. Like the predicate prion protein in vitro conversion diagnostics, these assays exploit the ability of endogenously misfolded proteins to induce misfolding and aggregation of their natively folded counterpart in vitro. This property enables biomarker detection of the underlying protein pathology. Herein, we review RT-QuIC and PMCA for (a) prion-, (b) α-synuclein-, (c) amyloid-β-, and (d) tau-opathies.

Although already in routine clinical use for the detection of transmissible spongiform encephalopathies, in vitro conversion assays for other neurodegenerative disorders require further development and evaluation of diagnostic performance before consideration for clinical implementation.
Forgotten solidarities in the Atelier Populaire posters
Authors: Memou Antigoni
Published: December 2019

This article examines some of the 'forgotten' posters of the Atelier Populaire, which were collectively produced by artists, workers, students and activists among others in the occupied Beaux-Arts school during the events of May '68. The article argues that alternative visual narratives are to be discovered in these posters, which break away from the representations of the events as youth revolt and the geographical reduction of the events to Paris and the Cartier Latin. Looking at them anew allows us to rediscover the unique solidarity among students, workers, farmers, the migrant workers and the unemployed, and to decipher the anti-capitalist character of the movement and its global dimensions.
May '68 on film: The renaissance of a political past
Authors: Besnard-Scott Laurence
Published: December 2019

Simone Weil's view that 'there is more of eternity in the past than in the present' may appear unexpected from a writer who is mostly known for her revolutionary and progressive texts, for she seems to defend a regression to a lost past; at least at first reading and if one solely reads it from a historicist perspective. On closer look, her reflections on time, originally written in French in the mid-1950s, are strangely relevant to our present time and its tendency to patronize the past. The 1968 events, and how we tend to perceive them in the now, are a case in point. Exploring the legacy of this collective protest as recorded on documentary films provides us with the opportunity to rediscover a particular kind of political activism that seems to be absent today, either absorbed into a broader mainstream culture, discredited as utopian or reduced to mere anachronism. Why should these artefacts still be viewed as evidence of the real world? And how do they materialize and sustain protest memory?
#IntersectionalActivism: Tales of origin and intersectional negotiations
Authors: Valdivia Angharad N.
Published: December 2019

Using a feminist intersectional paradigm, this article explores the invisibilization of intersectional black women and women of colour who initiate movements of hashtag activism. Focusing on #MeToo, #blacklivesmatter, #SayHerName and #OscarsSoWhite, the article explores the process of mediatization that refocuses the social movements on whiteness and/or males. The article finds this to be a continuity between digital and legacy media.
Continuum Generation by Generation: The representation of Chinese traditions at the China Pavilion of the 57th Venice Biennale
Authors: De Nigris Ornella
Published: December 2019

This article focuses on the China pavilion of the 57th Venice Biennale as a case study. The theme of the pavilion, Continuum – Generation by Generation, revolved around the long history of Chinese tradition and offered a visual re-elaboration of it by means of contemporary art and folk art. The works exhibited drew on Chinese mythology, masterpieces of Chinese art history, philosophical concepts and handcraft traditions, hence presenting a variegated image of (contemporary) Chinese art. This exhibition offers opportunities for a critical reading of the relationship between contemporary art and tradition implied by the theme Continuum, and I will explore the narrative and curatorial discourse it presented to the audience.