bluuebunny/crossref_metadata_2025 huggingface dataset:
Low Breast Milk Supply Demystified—The New Edition ofMaking More Milk: The Breastfeeding Guide to Increasing Your Milk Production
Authors: Robertson Barbara D.
Published: November 2019

Purpose

Low breast milk supply is a common concern among breastfeeding families and is cited as being one of the top reasons a family might stop breastfeeding. Research on the causes of low breast milk production and how to improve the rate of breast milk production is still emerging and not always in the field of human lactation.

Method

Barbara D. Robertson interviewed Lisa Marasco in June 2019 about her new book, co-authored by Diana West,Making More Milk: The Breastfeeding Guide to Increasing Your Milk Production, 2nd Editionto see how this new edition can help IBCLCs in their clinical work with families.

Results

Making More Milk: The Breastfeeding Guide to Increasing Your Milk Production, 2nd Editionis a valuable tool that can help clinicians assess if the individual families they are working with do indeed have a low milk supply, and then, if the family is struggling with low milk supply, provide a framework to investigate why the supply is low and what might be done to help improve the rate of breast milk production.

Conclusions

After the interview with Lisa Marasco and reading her manuscript, this new edition ofMaking More Milk: The Breastfeeding Guide to Increasing Your Milk Production, 2nd Editionis a valuable contribution to the field of human lactation.
İmmun checkpoint inhibitörleri ilişkili bağ dokusu hastalıkları
Authors: YAZICI Ayten
Published: November 2019

İmmün checkpoint inhibitörleri kanser tedavisinde kullanılan ve kullanımı gün geçtikçe artan ilaçlardır. Bu ilaçlarla hemen her organa ait immün ilişkili yan etkiler bildirilmiştir. Hepatit, kolit, pnömoni, döküntü, tiroidit, hipofizit en sık görülenlerdir. İmmün ilişkili yan etkiler genelde hafif-orta şiddette olup sıklığı %90’ının üzerinde bildirilmiştir. Romatolojik yan etkiler diğerlerine göre daha az bildirilmiş olmakla birlikte bu yan etkilerin gerçek sıklığı tam olarak bilinmemektedir. İmmün checkpoint inhibitörleri ile en sık bildirilen romatolojik yan etki artralji ve artrittir. Bunun dışında miyozit, sikka sendromu, skleroderma ve sarkoidoz ile ilişkili olgu bildirimleri de mevcuttur. Romatolojik yan etkiler konusunda farkındalığın artması bu olguların erken tanınması ve tedavisi açısından önemlidir
Osteoporozda farmakolojik tedavi
Authors: KİRAZLI Yeşim
Published: November 2019

Osteoporoz tedavisinde kullanılan ajanlar genellikle iyi tolere edilir ve oldukça etkindirler. Bisfosfonatlar ve RANKL inhibitörü denosumab gibi antirezorptifler en sık kullanılan osteoporoz ilaçlarıdır. Bu ajanlar postmenopozal osteoporozlu kadınlarda kemik mineral yoğunluğunu arttırırlar ve vertebral kırık (%40-70), vertebra dışı kırık (%25-40) ve kalça kırık (%40-53) riskini azaltırlar.  Şiddetli osteoporozu ve yüksek kırık riski olan hastalarda, tek başına bisfosfonatlar kırıklara karşı uzun vadeli koruma sağlayamayabilirler. Bu hastalar için, ardışık tedavi, kemik yapıcı bir ajanla (teriparatid) tedaviye başlanması ve bunu antirezorptiflerin izlemesi daha iyi bir uzun vadeli kırık engellenmesi sağlayabilir ve osteoporoz tedavisinin geleceği için altın standart olmalıdır. Bir hasta için ilaç seçimi tamamen hastayı tedavi edecek klinisyene bağlıdır ve hastanın genel sağlık durumu, tedaviye uyumu, tedavi ajanı tercihi, tedavi ajanlarının risk/ yararları düşünülerek ve ülkelerin sağlık sistemi ve özel koşulları göz önünde bulundurularak, osteoporoz tanı ve tedavi kılavuzlarının önerileri doğrultusunda karar verilir
A Tribute to Lewis Wolpert on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis
Authors: Durston Antony
Published: November 2019

This article is a tribute to Lewis Wolpert on the occasion of the recent 50th anniversary of the publication of his article ‘Positional Information and the Spatial Pattern of Differentiation’. This tribute relates to another of his ideas: his early ‘Progress Zone’ timing model for limb development. Recent evidence is reviewed that a mechanism sharing features with this model patterns the main body axis in early vertebrate development. This tribute celebrates the golden era of Developmental Biology.
Inpatient Nurses’ Perception on The Implementation of Acute Care Nursing in The Hasanuddin University Hospital
Authors: Hidayat Rahmat , Rachmawaty Rini , Lkafah Lkafah
Published: November 2019

Introduction: Acute care is a type of time-sensitive care, this is due to an acute condition requiring rapid intervention. Acute conditions that exist in the inpatient unit would require special care in handling. This acute condition can affect many things, one of which is the patient satisfaction. With proper treatment for acute cases, the course will improve patient satisfaction itself. However, to date, acute care has been poorly defined and inadequately supported in most developing health systems. Aims of Study: This research aims to determine nurses’ perception on the implementation of inpatient acute nursing care in the Hasanuddin University Hospital. Method: This research was a qualitative method, data collection using individual interviews against ten participants (inpatient nurses) and validity checks of the data that utilizes something beyond the data. Data analyze used thematic analysis. Result: The results of the research yield four themes. Those four themes are perception of acute conditions, supporting factors in the management of patients with acute conditions, inhibiting factors in the management of patients with acute conditions, and nurses’ hope for acute care. Conclusion: From this research it is known that the incidence of acute conditions in the inpatient unit of Hasanuddin University Hospital less than chronic conditions. To handle acute cases, nurse in the inpatient unit take action early by monitoring vital signs, then immediately gave emergency action if necessary, while collaborating with the doctor. Supporting factors for nurses is the availability of emergency trolly, as well as cooperation among nurses who are good. Whereas the inhibiting factor is the number of nurses who are still lacking and the absence of code blue team. Advice from researchers, to health institutions is expected to be able to form a rapid response team (code blue), so that patients with serious/acute condition can be handled more quickly and efficiently, so that the implementation of nursing, especially nursing acute to run well and the nurse also will not experience in serving patients overwhelmed.
A Comparison of Hot Pack and Stretching Exercises on Primary Dysmenorrhea in Adolescent Girls
Authors: Bachtiar Farahdina , Mursyid Andi Rabiatul Mahbuba , Sadmita Salki
Published: November 2019

Introduction: Dysmenorrhea or menstrual cramps is a pain (usually in the pelvis, lower back or abdomen) during menstruation. The pain usually begins several days before or during menstrual bleeding starts. It is often mild but in some cases, the symptoms may be more painful and cause discomfort. Dysmenorrhea is divided into two categories including primary (not associated with pelvic pathology) and secondary (resulting from underlying diseases) dysmenorrhea. The purpose of this study was to compare the effect of hot pack and stretching exercises on pain in adolescent girls with primary dysmenorrhea. Method: This was an experimental research with two group pre-test and post-test design. Twenty girls of students in Class X who met the inclusion and exclusion criteria were assigned in two groups: hot pack (n=10) and stretching exercise groups (n=10).  The menstrual pain was measured using the Visual Analogue Scale (VAS) before and after six times interventions. The pain score changes in each group were analysed using paired sample test while the comparison means for hot pack and stretching groups were assessed using independent samples t-test.  Result: The results revealed that the intensity of the pain in both hot pack and stretching exercises group were declined (p <.05). After conducting independent sample t-test, it was found that there was a statistically significant difference between the level of pain for the hot pack and stretching group (p = 0,001). Conclusion: Hot pack is more effective in reducing dysmenorrhea (menstrual pain) compare to stretching exercises.
Successful Treatment of Pediatric Posttraumatic Tibiofibular Synostosis by Resection and Peroneal Artery Perforator Adipofascial Flap
Authors: Nemoto Kazuaki , Sakai Noriko , Matsuda Satoshi , Kato Hiroyuki
Published: November 2019

Case:

Pediatric posttraumatic tibiofibular synostosis (PPTFS) is a rare postfracture complication that often leads to growth abnormalities. There are very few reports demonstrating the long-term efficacy of surgical treatment. An 11-year-old boy with PPTFS displayed progressive prominence of the fibular head and shortening of the lateral malleolus subsequent to a fracture suffered at the age of 5 years. He was treated by synostosis resection and a peroneal artery perforator adipofascial flap. Eight years postoperatively, the synostosis had not recurred, and his earlier growth abnormalities were nearly normal.

Conclusions:

Peroneal artery perforator adipofascial flap is effective for pregrowth spurt PPTFS.
Radiation-Free Management of Lumbar Spine Burst Fractures in Pregnant Women
Authors: R. Nalli Uvaraj , Vaithiyanadhan Singaravadivelu , Govindarajan Hemantha Kumar , Muthu Sathish
Published: November 2019

Case:

We present the strategies we used in surgical management of delayed presentation of traumatic lumbar fractures with neurological deficits in 2 young primigravida mothers in early trimesters of pregnancy. Posterior stabilization was achieved in a prone position using magnetic resonance imaging (MRI) without radiation.

Conclusions:

Management of spinal cord injury in pregnancy is a delicate scenario in which risks and benefits of surgery have to be explained to the patient for whom surgical management is contemplated. Risk of radiation to the fetus is completely avoided by using MRI perioperatively to assess injury and outcome.
Can ELABELA be a Novel Target in the Treatment of Chronic Lymphocytic Leukaemia?
Authors: Acik Didar Yanardag , Bankir Mehmet , Baylan Filiz Alkan , Aygün Bilal
Published: November 2019

Background: It has been shown that bcl2, bcl-XL and mcl-1 protein levels are high in chronic lymphocytic leukemia cells, and resultantly, apoptosis does not occur chronic lymphocytic leukemia cells. Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein coupled receptor called apelin receptor. Studies have shown that ELA inhibits apoptosis by inhibiting apoptotic proteins and activating anti-apoptotic proteins. Proteins and genes involved in apoptosis are valuable for targeted cancer therapy. We hypothesized that serum levels may be increased in patients with chronic lymphocytic leukemia based on the antiapoptotic effect of ELA. We compared serum apelin levels of healthy volunteers and patients with chronic lymphocytic leukemia. We aimed to draw attention to a new molecule worthy of research in targeted cancer treatment.
Methods: 42 untreated CLL patients and 41 healthy volunteers were included in the study. Serum ELA levels were measured by using enzyme-linked immunosorbent assay kits (Dhanghai Sunred Biological Technology co. Ltd), automated ELISA reader (Thermo Scientific, FİNLAND) and computer program (Scanlt for Multiscan F.C.2.5.1) in accordance with the manufacturer’s instructions. Statistical analysis was done by Statistical Package for Social Sciences for Windows 20 (IBM SPSS Inc., Chicago, IL) ve MedCalc programs. ELA and variables related to CLL were correlated with Spearman correlation anlysis test. ROC analysis and Youden index method were used to determine a cut off point for ELA. All p-values were 2-sided with statistical significance at 0.05 alpha levels.
Results: In our study, we found that serum ELA levels were significantly higher in patients with CLL.
Conclusions: This study highlights that ELA targeting may be a potential therapeutic option for treating CLL.
Keywords: ELABELA; apelinergic system; chronic lymphocytic leukaemia; apoptosis
Level of medication self-management capacity among patients on ambulatory care exiting hospital pharmacy at Muhimbili National hospital, Tanzania: a descriptive cross-sectional study
Authors: Mlyuka Hamu Joseph , Salehe Hija , Mikomangwa Wigilya P , Kilonzi Manase E , Marealle Alphonce I , Mutagonda Ritah F , Bwire George M.
Published: November 2019

Objectives: Medication management capacity of a patient on ambulatory care is direct related to adherence. To our knowledge data on medication management capacity for ambulatory care patients exiting outpatient pharmacy outlets in Tanzania are scarce. This study aimed to determine the level of medication management capacity among patients on ambulatory care exiting Muhimbili National Hospital outpatient pharmacy outlet.
Results: A total of 424 patients on ambulatory care participated in the study. Three hundred eighty seven (91.3%) out of 424 interview questionnaires had complete data and qualified for data analysis. Majority (62.3%) out of 387 study participants had poor medication management capacity; 65.3% out of 387 patients were unable to correctly read the prescription and match the drugs they are carrying. More than half (57.4%) out of 387 participants were unable to correctly take the dose, 73.9% out of 387 were unable to correctly tell the dosing frequency and duration. Only 10.6% out 155 patients with prescription containing drugs with warning or precaution or contraindication or potential side effects were aware.
Intention to Use Long Acting and Permanent Contraceptive Methods and Associated Factors in Health Institutions of Aksum Town, North Ethiopia
Authors: Syum Hailay , Kahsay Gizienesh , Huluf Teklehaymanot , Beyene Berhe , Gerensea Hadgu , Gidey Gebreamlak , Desta Haftom , Abay Mebrahtu , Nuguse Haben , Haile Kebede
Published: November 2019

Abstract
Objective: In Ethiopia, the majority of married women practice predominantly short-acting contraceptive methods. Therefore this study aims to assess intention to use LAPMs and its determinants among short-acting users in Health Institutions of Aksum Town, North Ethiopia.
Results: Prevalence of intention to use LAPMs was 52.1% (95% CI: 47.4-57.0). Good knowledge on LAPMs [AOR=2.15; 95% CI (1.29,3.56)], positive attitude towards LAPMs [AOR=3.41; 95% CI (1.99,5.85)], 18-24 years of age [AOR=3.18; 95% CI (1.30,7.79)], being primary school in educational level [AOR=0.34; 95% CI (0.14,0.78)], decision on the number of children jointly with partner [AOR=2.05; 95% CI (1.01,4.18)], having more than two children [AOR=10.67; 95% CI (1.29,88.31)], and no [AOR=10.21; 95% CI (3.10,33.58)] and one [AOR=4.70; 95% CI (1.68,13.13)] extra number of children desired were factors significantly associated with having intention to use LAPMs compared to their counterparts. The intention to use LAPMs was low. Therefore, appropriate information, education and communication strategies must be designed to raise awareness and change the negative attitude of the community on LAPMs.
Keywords: LAPMs, intention to use, factors, Axum, Ethiopia
Developing a High-Performance Liquid Chromatography Fast and Accurate Method for Quantification of Silibinin
Authors: Bakhshi Faezeh , Molavi Ommoleila , Rashidi Mohammad Reza , Shayanfar Ali , Amini Hassan
Published: November 2019

Objective : Silibinin is an antioxidant agent and is shown to have anticancer effects in different cancers including lung, breast, colorectal, liver, prostate, and kidney. There are challenges in the clinical use of silibinin. The main limitation is low solubility, poor oral absorption, and extensive hepatic metabolism. We aim to develop a High-Performance Liquid Chromatography (HPLC) sensitive method for quantification of silibinin in aqueous samples to quantify its concentration in new formulations. A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase and the mixture of methanol (90%) and water (10%) as mobile phase. The developed method was validated based on the established guidelines.
Results : The retention time for silibinin was seen in 2.97 minute after injection. The calibration curve was drawn and the established method demonstrated a linear ranged from 10 to 100 µg/ml, with a correlation coefficient of 0.996. The sensitivity of the developed method was 10 µg/ml. The accuracy calculated in the range of 88-105.9% and the precision (as relative standard deviation) was between 2.7-10.9%. These results demonstrate that the developed method can be a fast and accurate method for quantification of silibinin in aqueous samples.
Real-world data of eribulin in advanced and pretreated HER2-negative breast cancer in a Spanish comprehensive cancer center
Authors: Sirvén Milana Bergamino , Fernández-Ortega Adela , Stradella Agostina , Morilla Idoia , Falo Catalina , Vázquez Silvia , Castany Roser , Villanueva Rafael , Recalde Sabela , Pérez Valentí Navarro , Gil-Gil Miguel , Pernas Sonia
Published: November 2019

Background

Eribulin improves survival in pre-treated HER2-negative advanced breast cancer (ABC). However, limited data exist on co-morbidities and central nervous system (CNS) efficacy. The purpose of this study was to review eribulin’s efficacy and safety in everyday clinical practice with special focus on age, body mass index (BMI) and central nervous system (CNS) activity.Methods

An observational study was conducted in a series of HER2-negative ABC patients treated from January’14-December’17 outside a clinical trial. Objective Response Rate (ORR), Progression Free Survival (PFS), Overall Survival (OS), and association of clinical and pathological variables with outcome were evaluated.Results

Ninety-five women were treated with at least one cycle of eribulin. Median age was 57 (33-83), and 18% were obese. Median number of prior chemotherapies for ABC was 3 (2-5) and 76% of patients had visceral metastases, including 21% with CNS involvement. Most tumors were estrogen receptor-positive (79%). ORR and stable disease (SD) at 6 months were 26.2% and 37.5%, respectively. Remarkably, relevant CNS efficacy was observed with eribulin: 20% of patients obtained partial response and 25% SD. Treatment was generally well tolerated and manageable, with 29% grade 3 and 10.9% grade 4 toxicities. Median PFS and OS were 4.1 months (CI95% 3.2-4.9) and 11.1 months (CI95% 9.5-14.7), respectively. Triple-negative disease, >2organs involved and being younger than 70 years old were independent prognosis factors for worse OS in multivariate analysis. Most patients (75%) progressed in pre-existing metastases sites.Conclusions

In everyday clinical practice, eribulin’s efficacy seems similar to pivotal trials. CNS-efficacy was observed. TNBC, >2 organs involved and being younger than 70 years old were independent prognosis factors for worse OS. Remarkably, less incidence of grade 4-toxicity compared to previous studies was found.
Basic Characterization of Plant Actin Depolymerizing Factors: A Simplified, Streamlined Guide
Authors: Sengupta Sonali , Rajasekaran Kanniah , Baisakh Niranjan
Published: November 2019

Actin depolymerizing factors (ADFs) are small monomeric actin-binding proteins that alter the oligomeric state of cellular actin. Members of the ADF family can bind both the G-actin and F-actin in plants, and their functions are regulated by cellular pH, ionic strength and availability of other binding partners. Actin depolymerization activity is reportedly essential for plant viability. By binding to the ADP-bound form of actin, ADFs severe actin filaments and thereby provide more barbed filament ends for polymerization. They also increase the rate of dissociation of F-actin monomer by changing the helical twist of the actin filament. These two activities together make ADF the major regulator of actin dynamics in plant cell. Therefore, it is essential to measure the binding and depolymerization activity of the plant ADFs. Here, we present a simplified, streamlined step-by-step protocol to quickly measure these important functions of the ADF proteins in vitro.
Protective effects of salvianolate on myocardial injury or myocardial infarction after elective percutaneous coronary intervention in NSTE-ACS patients: a randomized placebo-controlled trial
Authors: Ou Yang , Sun Shengjia , Shi Haiming , Luo Jianfeng , Luo Xinping , Shen YunZhi , Chen Yufei , Zhu Zhidong , Liu Xiaojin , Fan Weihu , Shen Wei
Published: November 2019

Percutaneous coronary intervention (PCI) can cause myocardial injury or myocardial infarction. There is unmet need to reduce incidence or severity of PCI related myocardial injury or myocardial infarction. This study is to evaluate the protective effects of salvianolate on PCI related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients. Methods We enrolled patients with NSTE-ACS who underwent elective PCI. The patients were randomly assigned to the salvianolate group or the control group. The incidence and the severity of PCI related myocardial injury or myocardial infarction, in addition to major adverse cardiac events (MACEs) during one year follow-up after PCI were studied between the two groups. We also performed a multivariate logistic regression analysis to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective PCI. Results Compared with the control group, salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction (11.7% vs 26.5%, p = 0.035). The rate of MACEs or all-cause death within one month or one year after the procedure was not significantly different between the two groups. Conclusions Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction, although it does not influence clinical prognosis.
Barriers and facilitators to retaining a cohort of street-based cisgender female sex workers recruited in Baltimore, Maryland, USA: Results from the SAPPHIRE study
Authors: Silberzahn Bradley , Morris Miles B. , Riegger Katelyn E. , White Rebecca H. , Tomko Catherine A. , Park Ju N. , Footer Katherine H.A. , Huettner Steven S. , Sherman Susan G.
Published: November 2019

Background: Despite experiencing HIV/STIs, violence, and other morbidities at higher rates than the general public, street-based female sex workers are often absent from public health research and surveillance due to the difficulty and high costs associated with engagement and retention. The current study builds on existing literature by examining barriers and facilitators of retaining a street-based cohort of cisgender female sex workers recruited in a mobile setting in Baltimore, Maryland who participated in the SAPPHIRE study. Participants completed interviews and sexual health testing at baseline, 3-, 6-, 9-, and 12-months.
Methods: Retention strategies are described and discussed in light of their benefits and challenges. We also calculated analyzed raw and adjusted retention proportions at each follow-up period. Lastly, baseline sample characteristics were compared by number of completed visits across demographic, structural vulnerabilities, work environment, and substance use variables using F-tests and Pearson’s chi-square tests.
Results: Although there were drawbacks to each retention strategy, each method was useful in tandem in achieving a successful follow-up rate. While direct forms of contact such as phone calls, social media outreach, and email were useful for retaining more stable participants, less stable participants required extensive field-based efforts such as home and site visits that increase the likelihood of random encounters. Overall, adjusted retention exceeded 70% for the duration of the 12-month study. Participants who were younger, recently experienced homelessness, and injected drugs daily were less likely to have completed all or most follow-up visits.
Conclusion: Retention of street-based female sex workers required the simultaneous use of diverse retention strategies that were tailored to participant characteristics. With familiarity of the dynamic nature of the study population characteristics, resources can be appropriately allocated to the most likely method(s) of successful retention.
Establishing a protocol for the selection of zircon inclusions in garnet for Raman thermobarometry
Authors: Campomenosi Nicola , Rubatto Daniela , Hermann Joerg , Mihailova Boriana , Scambelluri Marco , Alvaro Matteo
Published: November 2019

The structural and chemical properties of zircon inclusions in garnet megablasts from the Dora Maira Massif (Western Alps, Italy) were characterized in detail using charge contrast imaging, Raman spectroscopy, and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The aim of this work is to determine to what extent the degree of metamictization, metamorphic recrystallization, inherent structural heterogeneity, chemical composition, and zoning, along with the elastic stress imposed by the host mineral, can influence the Raman peak position of the zircon inclusion and hence, the residual pressure estimated via Raman geo-thermobarometry. We show and confirm that metamictization and inherent structural heterogeneity have a major influence in the Raman spectra of zircon in terms of peak position and peak width. We suggest that, for spectral resolution of 2 cm−1, the peak width of the B1g mode near 1008 cm−1 of reliable grains must be smaller than 5 cm−1. The method can be applied to both inherited igneous and newly formed Alpine metamorphic crystals. By coupling structural and chemical information, we demonstrate that there are no significant differences between the Raman spectra of zircon with oscillatory-zoned texture, formed during magmatic crystallization, and those formed by fluid-induced Alpine (re)crystallization. The discrimination between magmatic and metamorphic zircon based only on micro-textural constraints is not robust. Finally, our results allow establishing a protocol devoted to the selection of reliable buried zircon inclusions, relying only on Raman spectroscopic measurements, to use for elastic thermobarometry applications.
Entrepreneurial strategies and practices for innovation in the hospitality industry
Authors: D. Zaridis Apostolos , Soldatou Helen , Soldatou Anna-Ipapanti
Published: November 2019

The hospitality industry is an increasingly developed sector in the international economy, and innovation and its results are relatively new subject of research. The purpose of this study is to identify the innovation initiatives that have been implemented in a particular sector, especially in the last decade, as well as those strategies and practices, which help to innovate in this sector worldwide. Based on an Online Desk Research, information was collected from some sources, i.e. electronic databases, business press and hospitality industry. The authors found out that these innovative activities include technological and non-technological activities that enterprises of the industry try to exploit and gain a competitive advantage in the market. A significant part of sector-specific innovation involves innovation implemented more on procedures and management than on the product itself. Technological or non-technological innovations have been used over the last decade by the hospitality sector enterprises to improve their ranking in competition. Operating several innovative activities of this kind should support businesses in the industry to gain one or more competitive advantages in the hospitality market, and the enterprises which are trying to innovate in this sector should implement a business growth strategy, but all of these activities need to be included in an integrated and appropriate business model.
Bioregulatory system medicine: from theory to practice
Authors: Kholodova I. N.
Published: November 2019

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Application of blood plasma enriched with platelet derived growth factors in experimental perforation of the tympanic membrane
Authors: Gurov A. V. , El’chaninov A. V. , Murzakhanova Z. V.
Published: November 2019

Acute traumatic perforation of the tympanic membrane occupies a significant place in the structure of the pathology of the middle ear, since «persistent» perforation of the tympanic membrane is the main cause of chronic inflammation in the middle ear, leading to hearing loss and reducing the quality of life of patients. «Persistent» perforation of the tympanic membrane, according to various authors, is formed in 84-392 cases per 10,000 population, so restoring the integrity of the damaged tympanic membrane is one of the main tasks of reconstructive otosurgery. Most authors are of the opinion that it is advisable to close the traumatic eardrum defect early. To date, many ways to close it have been developed. In modern otorhinolaryngology there is extensive experience in using various methods of myringoplasty using various materials for traumatic perforation of the tympanic membrane. However, such a wide variety of plastic techniques and the variety of materials used for this indicates an unresolved problem of closing the perforation of the tympanic membrane. To date, many works have been published that confirm the effectiveness of the use of blood plasma enriched with platelet growth factors in plastic surgery, cosmetology, traumatology, and dentistry. The result of exposure to blood plasma enriched with growth factors is the expression of proteins that regulate chemotaxis, adhesion, cell proliferation, angiogenesis, cell differentiation and the synthesis of extracellular matrix components. Blood plasma enriched with growth factors is autologous (biocompatible), safe from the point of view of the transfer of infectious pathogens. Thus, it can be assumed that the use of plasma enriched with growth factors during surgery during closure of acute perforation of the tympanic membrane will lead to accelerated tissue regeneration and, consequently, a reduction in the length of the postoperative period, and improved treatment outcomes. The use of this method is possible even in a day hospital.
Symptom dynamics assessment of the disease by methods of survival analysis
Authors: Korneenkov A. A. , Ryazantsev S. V. , Vyazemskaya E. E.
Published: November 2019

The article discusses typical tasks of quantitative comparison and analysis of the effectiveness of diagnostic medical technologies. Indicators of clinical informativeness of diagnostic methods, quantitative methods for their calculation and interpretation, their importance for making diagnostic decisions are discussed. Using one of the diagnostic methods as an example, algorithms for comparing the test diagnostic test with the gold standard test according to clinical information indicators are described: sensitivity, specificity, positive and negative predictive value of test results, accuracy, likelihood ratio of positive and negative test results. The problems of constructing ROC curves by the example of diagnostic indicators of nasal obstruction: airflow and pressure, as well as the calculation and presentation of AUC (in one figure), finding diagnostic threshold points for two tests (changes in flow and resistance), and testing the statistical hypothesis about the equality of AUC of these two tests, creating a nomogram for calculating the post-test probability of illness. It is shown how, using the presented technique, it is possible to efficiently calculate all the standard operational characteristics of diagnostic medical technologies and additional useful indicators. All calculations were performed in the statistical program R. The text of the article presents program codes of the R language with explanations.
Histological examination of the palatine tonsils in chronic tonsillitis
Authors: Pal’chun V. T. , Gurov A. V. , Dubovaya T. K. , Ermolaev A. G.
Published: November 2019

The article is devoted to the problem of chronic tonsillitis. The aim of the study was to assess changes in the morphofunctional state of the palatine tonsils in chronic inflammation. The study presents comparative data of immunohistochemical examination of the tonsils in normal and chronic tonsillar pathology. The authors used the clinical classification of chronic tonsillitis developed by B.S. Preobrazhensky and V.T. Pal’chun. Histological changes in the palatine tonsils of patients with toxic-allergic form 2 chronic tonsillitis were described in accordance with this classification. The control group represented palatine tonsils tissue taken from patients without chronic tonsillitis. The examination was carried out using markers of apoptosis, antiapoptosis, cell proliferation, as well as various types of lymphocytes. The authors describe a tonsil tissue handling technique, morphological and functional state in each study group, compared the studied parameters in two groups, reflected the dynamics of changes in the palatine tonsils with chronic tonsillitis. Increased apoptotic and anti-apoptotic activity combined with decreased cell proliferation, increased number of T-helpers and B-lymphocytes gives evidence of significantly decreased functional activity of the palatine tonsils in chronic inflammation. These changes are correlated with the clinical picture to develop the most optimal management of the disease.
A modern approach to the comprehensive treatment of allergic rhinitis
Authors: Karpishchenko S. A. , Lavrenova G. V. , Mil’chakova A. S.
Published: November 2019

The problem of allergic rhinosinusopathies is one of the most pressing in modern rhinology. It has drawn the attention of clinicians for several decades. Allergic rhinitis is a common disease, the onset of which often come in early childhood. In later life, this disease significantly reduces the quality of life. The widespread prevalence of allergic rhinitis among children and able-bodied adults, growing incidence rates of the disease represent a significant medical and social problem. Allergic rhinitis should be treated by otorhinolaryngologists and allergists-immunologists. Given the pathogenetic mechanisms of the disease, it is necessary to act upon the local symptoms and total body. Extension of disease remissions, teaching patients the principles of elimination therapy and how to maintain a healthy microclimate at home, relapse prevention are the main directions in the treatment of allergic rhinitis. The primary task of otorhinolaryngologists and allergists-immunologists is to restore unlabored nasal breathing in such patients. Symptomatic therapy includes administration of vasoconstrictor drugs, anticholinergics, cromons, local and systemic antihistamines, leukotriene receptor blockers, topical and systemic glucocorticosteroids (GCS), sorbents, pre- and probiotics. Despite the fact that the symptomatic therapy methods cannot provide a long-lasting effect after cancellation, local symptomatic treatment of allergic rhinitis using topical corticosteroids is generally accepted and widely used in the otorhinolaryngology practice. Flixonase is one of the topical corticosteroids that are often prescribed for allergic rhinitis. The aim of our paper was to evaluate the effectiveness of the treatment regimen of allergic rhinitis using Flixonase as a local GCS. 24 people with perennial allergic rhinitis aged from 19 to 38 years were under our observation. The following therapy was prescribed to the patients: decongestants, rinsing the nasal cavity with saline (saltwater) solutions, corticosteroids (Flixonase), mild sedatives. Flixonase showed its efficacy in our study.
Treatment of acute rhinitis in children
Authors: Ryazantsev S. V.
Published: November 2019

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L’Esprit du Sacré: Le Corbusier and the necessary Utopia of Sainte Marie de La Tourette
Authors: Alison Aurosa , Cafiero Gioconda
Published: November 2019

“L’homme qui recherche l’harmonie a le sens du sacré”. In this way Le Corbusier claims the main difference between holiness and spirituality. In the omitted comparison, it is clear that the Architect's main interest is to highlight the strong laical and spiritual character of which is harmonious both in Nature and Architecture. Thanks to this approach, the democratic reception of the spiritual feeling overcomes the sacred one which remains linked to semantics stratifications that still require interpretation. In order to develop a democratic vision to community life, Le Corbusier entrusts the rules of a daily living, with the contingent possibilities of a community such as the Dominican one and also with the need to individual seclusion, celebrating immanence and silence. “Loger dans le silence des hommes de prière et d’étude et leur construire une église”.The celebration of both prayer and community life is what Le Corbusier wants to achieve, without distracting attention from the main purpose of the spiritual and individual growth, that nourishes the utopian function of this project. This shares a common research with the other architectures conceived for a community life such as l’Unité d’Habitation or the Swiss Pavilion.   This is the way the liturgical spaces welcome daily life evaluating un homme de 24 heures, arranging an hermeneutical relationship between places for gathering and meditation. From this we can acknowledge that architecture of the Le Corbusier’s Convent, allows holy inspirational feelings among liturgical and environmental spaces. All this is due to an hard intellectual work based on humanism, far from faith, but open to spiritual values and mystical feelings which place Beauty as an existential motivation for a religious work, including human dimension and the answers to his needs.
Swimming Impacts on Pancreatic Inflammatory Cytokines, miR-146a and NF-кB Expression Levels in Type-2 Diabetic Rats
Authors: Alipour Mohammad Reza , Yousefzade Nasibeh , Bavil Fariba Mirzaei , Naderi Roya , Ghiasi Rafighe
Published: November 2019

Background:

Obesity-induced chronic inflammation is a key component in the pathogenesis
of insulin resistance and type-2 diabetes

Objective:

This study aimed to evaluate the effect of swimming exercise on pancreatic expression levels
of inflammatory cytokines, miR-146a and NF-кB in type-2 diabetic male rats.

Method:

Twenty- eight male Wistar rats were divided into four groups: control (Con), exercise, diabetes
and diabetic exercise (n = 7). Diabetes induction performed by the combination of high-fat diet
(HFD, 4 weeks) and streptozotocin (35 mg/kg. ip). After induction of diabetes, the rats swam in the exercise
groups for 12 weeks. Then, blood and tissue samples were collected.

Result:

Our results indicated a significant increase in expression levels of miR-146, NF-κB and inflammatory
cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression
levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming
exercise resulted in a significant decrease in expression levels of miR-146a, NF-кB and inflammatory
cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic
group compared to the diabetic group.

Conclusion:

Our results indicated a significant increase in expression levels of miR-146, NF-κB and
inflammatory cytokines (IL-6, TNF-α, and IL-1β) while a significant decrease in pancreatic expression
levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming
exercise resulted in a significant decrease in expression levels of miR-146a, NF-кB and inflammatory
cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic
group compared to the diabetic group.
Role of General Adversarial Networks in Mammogram Analysis: A Review
Authors: Gopal Annapoorani , Gandhimaruthian Lathaselvi , Ali Javid
Published: November 2019

The Deep Neural Networks have gained prominence in the biomedical domain, becoming
the most commonly used networks after machine learning technology. Mammograms can be
used to detect breast cancers with high precision with the help of Convolutional Neural Network
(CNN) which is deep learning technology. An exhaustive labeled data is required to train the CNN
from scratch. This can be overcome by deploying Generative Adversarial Network (GAN) which
comparatively needs lesser training data during a mammogram screening. In the proposed study, the
application of GANs in estimating breast density, high-resolution mammogram synthesis for clustered
microcalcification analysis, effective segmentation of breast tumor, analysis of the shape of
breast tumor, extraction of features and augmentation of the image during mammogram classification
have been extensively reviewed.
Granulomatosis with Polyangiitis (GPA) in a 15-year-old Girl with Facial Acne-like Ulcers: A Case Report
Authors: Jamali Moghadam Saeed Reza , Salehi Mohammad Reza , Mojtahedi Seyed Yousef , Fadaei Narges , Dadras Omid , SeyedAlinaghi SeyedAhmad , Mohammadifirouzeh Mona
Published: November 2019

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis
(WG), is a multisystem autoimmune disease of unknown etiology often misdiagnosed as pneumonia.
The hallmark features include necrotizing granulomatous inflammation and pauci-immune
vasculitis in small and medium-sized blood vessels. We described a 15-year-old female with a history
of six months of acne-like facial and peri-auricular lesions. She had received conventional
treatment for acne (antibiotics + topical corticosteroid) with no response. She also had a history of
chronic coughs, which always diagnosed and treated as sinusitis. In addition, she had a history of
frequent dysuria, which always diagnosed and treated as a urinary tract infection. Given the history,
with suspicion of a multi-systemic disease such as vasculitis; we performed some diagnostic
laboratory and radiologic tests in order to rule out the possible etiologies. The results were positive
for cytoplasmic anti-neutrophil cytoplasmic antibody (C-ANCA). The urine analysis suggested
the involvement of kidney micro-vasculature. In addition, two nodular lesions with the cystic
pattern were observed in the CT scan of the lungs. However, the skin and nasal biopsies revealed
no evidence of chronic necrotizing vasculitis or granulomatous lesion. Nonetheless, treatment
was initiated with a strong suspicion of GPA. Following the treatment, the patient's symptoms
completely disappeared, and the diagnosis of GPA was confirmed.
Objective and Subjective Physical Measures of the Neighbourhood Environment among Older People
Authors: Nordin Nadhirah , Nakamura Hitoshi , Bhattacharya Yasmin
Published: November 2019

This paper aims to explore the relation between objective and subjective neighbourhood walkability and its impact on the physical activity level of older adults. The correlations were used to signify older people's level of physical activity in Johor Bahru neighbourhoods, Malaysia. The results show residents in a highly dense area with higher accessibility to facilities perceived higher walkability level but showed a lower actual physical activity level. People living in high intersection density areas who recognised high walkability demonstrated higher physical activity level, while residents in a highly dense area with higher accessibility show lower physical activity level. This implies that neighbourhoods with high intersection density demonstrated a highly walkable environment rather than neighbourhoods with high density and high accessibility.
Traditional Ecological Knowledge and Climate Change Adaptation: The Sa'ban experience
Authors: Hosen Nadzirah , Nakamura Hitoshi , Hamzah Amran
Published: November 2019

Indigenous people often rely on natural resources for their livelihoods. This reliance increases their vulnerability towards the impacts of climate change, and coping with increased climate variability is a significant challenge for such communities. This research, conducted among the Sa'ban tribe of Long Banga in interior Sarawak, Malaysia, explored observations of local climate change, climate change impacts and tribal adaptation strategies. The results show that drought, wildfires and uncertain weather conditions are the Sa'ban's primary concerns. However, the tribe have demonstrated their adaptation strategies through the use of traditional ecological knowledge (TEK).
A Chatbot-Based Coaching Intervention for Adolescents to Promote Life Skills: Pilot Study
Authors: Gabrielli Silvia , Rizzi Silvia , Carbone Sara , Donisi Valeria
Published: November 2019

Background

Adolescence is a challenging period, where youth face rapid changes as well as increasing socioemotional demands and threats, such as bullying and cyberbullying. Adolescent mental health and well-being can be best supported by providing effective coaching on life skills, such as coping strategies and protective factors. Interventions that take advantage of online coaching by means of chatbots, deployed on Web or mobile technology, may be a novel and more appealing way to support positive mental health for adolescents.

Objective

In this pilot study, we co-designed and conducted a formative evaluation of an online, life skills coaching, chatbot intervention, inspired by the positive technology approach, to promote mental well-being in adolescence.

Methods

We co-designed the first life skills coaching session of the CRI (for girls) and CRIS (for boys) chatbot with 20 secondary school students in a participatory design workshop. We then conducted a formative evaluation of the entire intervention—eight sessions—with a convenience sample of 21 adolescents of both genders (mean age 14.52 years). Participants engaged with the chatbot sessions over 4 weeks and filled in an anonymous user experience questionnaire at the end of each session; responses were based on a 5-point Likert scale.

Results

A majority of the adolescents found the intervention useful (16/21, 76%), easy to use (19/21, 90%), and innovative (17/21, 81%). Most of the participants (15/21, 71%) liked, in particular, the video cartoons provided by the chatbot in the coaching sessions. They also thought that a session should last only 5-10 minutes (14/21, 66%) and said they would recommend the intervention to a friend (20/21, 95%).

Conclusions

We have presented a novel and scalable self-help intervention to deliver life skills coaching to adolescents online that is appealing to this population. This intervention can support the promotion of coping skills and mental well-being among youth.
Структурные особенности ультрамелкозернистой стали ЭИ-961Ш с наноразмерными карбидными частицами при циклическом нагружении
Authors: Nikitina M.A. , Исмангалиев Р.К. , Ганеев А.В. , Ситдиков В.Д.
Published: November 2019

Представлены результаты исследования влияния ультрамелкозернистой структуры на усталостные свойства ферритно-мартенситной стали. Исследованы структурные изменения после усталостных испытаний. Методами растровой электронной микроскопии и просвечивающей электронной микроскопии изучены особенности усталостного излома и эволюция микроструктуры от расстояния до места разрушения. Методами рентгеноструктурного анализа определены параметр решетки, область когерентного рассеяния, плотность дислокаций, объемная доля и размер карбидных частиц. Обсуждается влияние УМЗ-структуры, объемной доли и размера карбидных частиц на механизм разрушения при многоцикловых испытаниях.
Гибкая печатная конформная электроника. Отечественные компетенции и электронные компоненты
Authors: Лучинин В.В. , Бохов О.С. , Афанасьев П.В. , Мандрик И.В. , Старцев В.А. , Смирнов А.В. , Никонова В.А.
Published: November 2019

Показан результат разработки и изготовления электронных компонентов, созданных с использованием технологии гибкой печатной электроники, сверхтонкого утонения чипов кристаллов активных элементов и 2D микросборочных операций на тонком гибком носителе для унифицированной сенсорно-информационной платформы Интернета вещей.
ИНДУСТРИЯ БУДУЩЕГО: МИФ ИЛИ РЕАЛЬНОСТЬ?
Authors: Катаева Е.Г.
Published: November 2019

ИНТЕРВЬЮ С РЕКТОРОМ МГТУ «СТАНКИН» Е. КАТАЕВОЙ