bluuebunny/crossref_metadata_2025 huggingface dataset:
Manejo odontológico de los pacientes bajo tratamiento médico con bifosfonatos en el servicio de odontología del Hospital General de Zona con Medicina Familiar N.° 21 en León, México
Authors: Ayala Cortés Fernando , Sánchez Barajas Mauricio , Gerez Álvarez Karla Patricia
Published: September 2023

Objetivo: Identificar los medicamentos que pueden provocar efectos secundarios a nivel bucodental durante la atención odontológica en el Hospital General de Zona con Medicina Familiar N.o 21, en León, México. Materiales y métodos: Se realizó un estudio observacional, descriptivo, transversal y retrospectivo en un grupo de pacientes de ambos sexos con padecimientos óseos, metabólicos u oncológicos manejados con bifosfonatos y que estuvieran llevando su tratamiento en el Hospital General en mención. Se revisaron 30 expedientes clínicos de pacientes con tratamiento con bifosfonatos y con alguna patología oral como consecuencia del uso de estos. Resultados: De los 30 pacientes, la enfermedad más frecuente fue la osteoporosis (19 %), seguida de cáncer de mama (7 %) y de cáncer de próstata (4 %), solo 7 pacientes recibieron atención dental; más de la mitad (58 %) son hipertensos y están bajo tratamiento médico. De los pacientes, 26 fueron del género femenino. El 50 % de los pacientes tomó su medicamento vía oral, ninguno por vía intravenosa; la otra mitad recibieron paliativos. La mayoría de pacientes tiene edad avanzada, con un promedio de 66.9 años. Conclusión: La osteoporosis es una de las enfermedades más frecuentes, afectando sobre todo a mujeres. El 80 % de pacientes no acuden al servicio dental o lo desconocen; son pacientes que tienen predisposición a padecer osteonecrosis relacionada con los medicamentos en uno o ambos maxilares.
Of The Use Of Village Funds In Batu Village, Bandung, Muara Kemumu District, Kepahiang District
Authors: Kooh Devison
Published: September 2023

This study aims to evaluate the Use of Village Funds and find out the obstacles to the Use of Village Funds in Batu Bandung Village, Muara Kemumu District, Kepahiang Regency. This research is an exploratory research with a qualitative approach. The informants in this study were: Camat, Head of BPD, Village Head, Community leaders, Communities in Batu Bandung Village, Muara Kemumu District, Kepahiang Regency. The informants in this study were taken using a purposive sampling method. The data analysis technique in this study was through the stages of data reduction, data presentation and drawing conclusions. The results of the study show that the national economic recovery program according to village authority has not been running and the national priority program according to village authority has not been running and the adaptation to new village habits in Batu Bandung Village, Muara Kemumu District, Kepahiang Regency has been going well.
Development In Bengkulu Utara District Government (Study On National Unity And Politics Agency)
Authors: Syahrin Alfi
Published: September 2023

This study aims to find out and analyze Organizational Development and to find out and analyze obstacles in Organizational Development at the National Unity and Politics Agency at the National Unity and Politics Agency in North Bengkulu Regency. The research method used in this study is a qualitative research method. Informants in this study were taken by purposive sampling method. Informants in this study were 5 people namely: Head, Secretary, Head of Section, and staff of the National Unity and Political Agency of the North Bengkulu Regency Government. Analysis of the data in this study through the steps of data collection, data reduction, data display, and conclusion. The results showed that the organizational development of the National Unity and Politics Agency for the North Bengkulu Regency Government had not been implemented optimally because organizational development had not been matched by increasing the capacity of the civil apparatus through training, courses, trainings and there was still a lack of understanding of each Head of Subdivision on their main duties and functions, so that the implementation of work programs from each field has not been carried out and the obstacles to organizational development of the National Unity Agency and Politics of the North Bengkulu Regency Government are still lacking staff both at the level of the Head of Sub-Divisions and Heads of Sector, there is still a lack of support for increasing knowledge through training and training, training, seminars and budget support from the Regional Government for programs that are national priorities are still not optimal and there is still a lack of facilities and infrastructure to support work, such as operational cars and laptops or PCs.
PENGENALAN DAN PEMBELAJARAN URBAN FARMING MELALUI BUDIDAYA SISTEM HIDROPONIK DEEP FLOW TECHNIQUE (DFT) PADA SISWA SISWI SEKOLAH DASAR DAN MENENGAH DI KOTA MALANG
Authors: Setyarini Putu Hadi , Fajriani Sisca , Roviq Mochammad , Hadi Sulistyarini Dwi , Aisyah Diana
Published: September 2023

A challenge in implementing green school initiatives is the lack of hydroponic cultivation learning facilities in the educational setting and the lack of space for planting productive plants in the environment of SDI As Salam and SMPIT As Salam as partners for community service activities. Teachers and students with little experience in hydroponic plant production techniques on small plots of land present another challenge for partners. All school constituents, namely teachers and students, are involved in hydroponic plant growth activities as part of the participatory rural appraisal (PRA) approach to activity implementation. Project for Strengthening Pancasila Student Profiles (P5) activities offer support through workshops for instructors and hydroponic farming techniques for teachers and students. The aims of mentoring are to: (1) teach fundamental information about hydroponic plant cultivation methods; (2) Integrate hydroponic culture learning facilities into the educational setting. The ability of students and teachers to carry out hydroponic activities, from planting seeds, caring for plants, and harvesting vegetable plants using the hydroponic method, is one indicator of the activity's success. Another is the presence of a hydroponic module in the partner environment that is used as a teaching tool for hydroponic cultivation in the school environment.
IPTEK BAGI MASYARAKAT MESIN PENGIRIS BAKAL KEMPLANG DI DESA PENYAMUN
Authors: Pristiansyah Pristiansyah , Yudha Hanafi Falah , Haritsah Amrullah Muhammad , Zulfitriyanto Zulfitriyanto , Hasdiansah Hasdiansah
Published: September 2023

Kemplang is a typical Bangka Belitung food made from mackerel or machete fish, and can also be made from squid, shrimp and sago. Kemplang has a round shape with a savory and crunchy taste when bitten. Kemplang can be consumed directly and can also be combined with typical Bangka Belitung shrimp paste which will make the taste of kemplang more diverse. The method of implementation at the completion of this final project is outlined on the flow chart. Conceptualizing a method like this has the aim that the work to be done is more directed so that what is done runs smoothly. Engine design using the VDI 2222 method makes it easier for designers to make machine designs so that they get a kemplang slicer design that can slice kemplang. PKK in penyamun village have difficulty in the process of slicing kemplang because they still use human labor, non-uniform kemplang slices and the time required in the slicing process is long. The slicing machine will be kemplang which is driven by an electric motor can slice 5 kemplang butts with a length of 30 cm and a diameter of 50 cm, and is also able to produce kemplang sheets with a thickness of ± 2 mm with a capacity of 20 kg / hour.
EASY WAY OF DRUG PICKING
Authors: s c Shyamala , r Lavanya , b s Sangeetha , br Chethan ,   PESITM
Published: September 2023

Medical shops are playing a vital role in human health care system now a day. When the medical shop is more crowded, customers struggle to purchase medicines. This creates a significant problem for the supplier in terms of delivering medicines to customers on time and during an emergency. The suggested method employs an autonomous robot that picks up the medicine from a storage area and puts it in the dispenser box without the need for human intervention. It solves the problems of the existing system, which is operated manually.
CRITICAL PERSPECTIVE ON MAN, SCIENCE AND NATURE INTERACTIONS
Authors: Mishra Dr. Upasana , Nandan Pandey Bihari , P Singh Raghavendra ,   Ajay Kumar Garg Engineering College
Published: September 2023

: Homo sapiens share a common dwelling place, the earth; and also, the resources, available on the planet. This association of man and nature is a fundamental reality of human civilization, and many scientific innovations were been made towards it, targeting a fulfilling life. But the paradox is that mechanization and scientific advancements are being proved as a great challenge to humanity and peace. The human species is witnessing an existential threat with exponentially growing scientific innovations and mechanization. Knowledge (education)is pivotal in guiding, understanding nature's inherent harmony, and aligning innovative mindsets towards continuous happiness and prosperity. The objective of the present communication is the critical analysis of our desire for harmony among humans, science and nature; and to unveil the current status of contrariness.
The Significance and Burden of Congenital Cytomegalovirus Infection: Interviews with Two Leading Experts
Authors: Jones Christine E. , Pesch Megan , Scott Brigitte
Published: September 2023

Human cytomegalovirus (CMV) is a member of the family Herpesviridae. This virus can remain dormant in the body over a long period after initial infection. Transmission of CMV occurs through direct contact with bodily fluids, such as saliva, urine, blood, semen, and breast milk, from individuals who are actively shedding the virus in these bodily fluids. CMV is extremely common and is found throughout all geographical locations and socioeconomic groups. Congenital cytomegalovirus (cCMV) infection is the most common congenital infection globally and has potentially severe consequences for infants; however, there is little awareness of cCMV infection among pregnant females, families, and healthcare professionals (HCP).

For this article, EMJ conducted interviews in March 2023 with two leading experts: Christine E. Jones from the University of Southampton and University Hospital Southampton NHS Foundation Trust, UK; and Megan Pesch from the C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor, USA, and the National CMV Foundation, Tampa, Florida, USA, both of whom have a wealth of experience and expertise in the management of cCMV. The experts gave valuable insights into topics such as the impact of cCMV infection on infants and their families and on public health; and screening, diagnosis, and treatment of cCMV infection. The experts also explored the potential complications of cCMV, particularly sensorineural hearing loss, the importance of prevention of maternal infection, and strategies to raise awareness of cCMV infection among HCPs and the public. In addition, Pesch provided a patient advocate perspective on the consequences of cCMV infection, sharing their experience of how cCMV has impacted their child, themself, and their family.
Implicature on Meme THR (Eid Allowance)
Authors: Siah Fenny Tri , Septiyatik Dyta , Fikri Fikri
Published: September 2023

This research focuses on implicature found in Meme THR (Tunjangan Hari Raya) to find out form, function, factor of language style which is as one of culture unsures. Based on the result of data analysist, meme THR are divided into 2 (two) time criteria such as pre or close to feast day and in the feast days. There are 12 (twelve) data used in this research which are divided into 7 (seven) data of meme THR in pre or close to feast day while there are 5 (five) data of meme THR in the feast days.  The forms of meme THR found in Google are declarative, interrogative, and imperative while directive, representative, and expressive are found as functions of them. Lastly, there are also some factors of language style found in meme THR such as apophasist, parallelism, personification, sarcasm, contradiction, preterio, and euphemism.
Uji Validitas Pengembangan E-Modul Materi Ekosistem Sebagai Sumber Belajar Biologi Pada Kelas X SMA
Authors: Nadira Nurasih , Lodang Hamka , Wiharto Muh.
Published: September 2023

Modul elektronik (e-modul) materi ekosistem sebagai sumber belajar Biologi merupakan hasil penelitian pengembangan atau Research and Development. Tujuan dari penelitian ini untuk menghasilkan e-modul materi ekosistem kelas X SMA yang bersifat valid. Penelitian dilaksanakan pada Juli 2022. Jenis penelitian ini adalah Research and Development (R&D) dengan model pengembangan ADDIE yang memiliki lima tahapan, yaitu analisis (analyze), desain (design), pengembangan (development), implementasi (implementation), dan evaluasi (evaluation). Subjek penelitian ini adalah 2 orang dosen ahli Jurusan Biologi FMIPA UNM selaku validator ahli yang melakukan penilaian validitas terhadap produk yang dikembangkan. Hasil penelitian menunjukkan, bahwa produk e-modul yang dikembangkan bersifat valid. Hasil validitas berada pada kategori sangat valid dengan skor validitas e-modul yang diperoleh yaitu 4,29 dengan kategori sangat vaid. Maka, dapat disimpulkan bahwa e-modul materi Ekosistem sebagai sumber belajar Biologi pada Kelas X SMA yang dikembangkan telah memenuhi kriteria valid.
Potensi Pupuk Organik Cair Limbah Kulit Kopi Robusta (Coffea canephora L.) di Perumda Perkebunan Kahyangan Jember
Authors: Brilliantina Aulia , Wibisono Yossi , Sari Elok Kurnia Novita , Adhamatika Adhima , Triardianto Dimas , Prayitno Prayitno , Arifiana Nisa Budi
Published: September 2023

Kopi merupakan salah satu komoditas perkebunan yang paling banyak diminati didunia, termasuk di Indonesia. Indonesia merupakan negara terbesar keempat sebagai penghasil biji kopi terbanyak di dunia pada tahun 2020 sebanyak 726,38 ribu ton. Perumda Perkebunan Kahyangan merupakan salah satu BUMD pemnghasil biji kopi robusta terbanyak di Indonesia dengan areal tanaman kopi robusta seluas 760 Ha dengan produktivitas 300 ton biji kopi/tahun dan cukup berpotensi untuk mendukung tekad Pemkab Jember sebagai kota kopi robusta di Indonesia. Permasalahan yang sering terjadi yaitu banyaknya limbah kulit kopi yang dihasilkan perumda selama produksi yang tidak dimanfaatkan secara optimal. Penelitian ini mengangkat potensi kulit kopi sebagai bahan baku utama POC. Hasil pengujian didapatkan bahwa POC dari limbah kulit kopi memenuhi standar mutu pupuk cair dari Kementrian Pertanian. Hasil ini menunjukkan potensi untuk dikembangkan lebih jauh dari POC kulit kopi dengan N-total sebesar 0,084%, C-ogranik sebesar 0,065%, P2O5 0,026%, K2O 0,071%, Fe 43,412 ppm, Mn 99,644 ppm, C/N Ratio 0,780%, Trichoderma sp. 2,83 x 105 cfu/ml, dan Aspergillus sp 1,81 x 105 cfu/ml.
Optimalisasi Kondisi PCR Untuk Amplifikasi Sekuen Gen HBB
Authors: Jannah Magfirahtul
Published: September 2023

Gen HBB merupakan salah satu gen yang berperan dalam sintesis hemoglobin, khususnya protein β-globin. Berbagai metode analisis molekuler untuk mendeteksi kelainan atau varian pada gen penyandi hemoglobin membutuhkan produk amplifikasi DNA yang berkualitas. Penelitian ini bertujuan menentukan kondisi PCR paling optimal untuk mengamplifikasi sekuen gen HBB dari sampel darah. Kami melakukan uji kualitatif dan kuantitatif pada DNA sampel yang telah diisolasi, lalu mengamplifikasi sekuen gen HBB menggunakan 2 pasang primer dengan 6 variasi komposisi master mix dan suhu annealing. Hasil penelitian menunjukkan bahwa DNA sampel berhasil diisolasi dengan rasio kemurnian 1,925 dan konsentrasi 48,9 µg/ml. Produk amplifikasi menggunakan primer HBE01 sangat tipis dan tidak spesifik, sedangkan primer HBE02 berhasil mengamplifikasi sekuen gen HBB dengan spesifik dan tampak cukup tebal. Amplifikasi sekuen gen HBB lebih baik menggunakan primer HBE02 dengan komposisi master mix dan suhu annealing sesuai Mix 6.
Pengembangan Media Audio Visual Berbasis Powtoon Pada Materi Bioteknologi Untuk Kelas IX SMP
Authors: Labibah Haura , Ajizah Aulia , Sari Mella Mutika
Published: September 2023

Powtoon adalah perangkat presentasi online yang menawarkan berbagai gambar dan template untuk membuat presentasi yang menarik. Siswa SMP umumnya cenderung menyukai media pembelajaran audio visual yang bergerak. Penelitian ini bertujuan untuk : 1) mendeskripsikan kelayakan media pembelajaran menggunakan powtoon sebagai media pembelajaran berdasarkan penilaian dari ahli media, ahli materi, guru, dan siswa, 2) untuk mendeskripsikan hasil belajar siswa setelah menggunakan media audio visual powtoon. Penelitian ini merupakan penelitian pengembangan Research and Development (R&D) yang menggunakan model ADDIE (Analyze, Design, Development, Implementation, Evaluation). Penelitian ini diuji cobakan pada peserta didik kelas IX A di SMPN 14 Banjarbaru. Teknik analisis data yang digunakan yaitu persentase kelayakan media, N-Gain, dan uji T. Hasil penelitian menunjukkan bahwa hasil uji kelayakan sebesar 84,46 %, respon guru sebesar 80 %, dan hasil rata-rata respon siswa memperoleh skor sebesar 80,2 %. Hasil belajar siswa memperoleh kategori sedang dengan skor N-gain 0,46. Berdasarkan hasil uji T diperoleh data nilai t hitung sebesar 8,546 dan t tabel sebesar 2,064 dengan signifikansi pada uji T adalah 0,000<0,05 maka terdapat perbedaan yang signifikan antara hasil belajar sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan bahwa media ini layak untuk diterapkan pada peserta didik SMP kelas IX A dan dapat meningkatkan hasil belajar peserta didik pada materi Bioteknologi.

Kata Kunci : Audio visual, Hasil Belajar, Media Pembelajaran,  Powtoon
Analysis of Precipitation Phase of Alloy1.4957 Heat-Resistant Steel for Gasoline Turbocharger
Authors: Lee Jong-Kwan , Lee Byeong-Joo , Lee Eon-Sik
Published: September 2023

Recently, strengthened environmental regulations have required the downsizing of gasoline engines, and as a result, demand for gasoline turbochargers has rapidly increased. The vane of a turbocharger controls the flow of gases toward the turbine, and it is manufactured by powder metallurgy due to its complex shape. Gasoline engines have a high exhaust gas temperature (~1000oC), and thus, Alloy1.4957 (GX15CrNiCo21-20-20) containing large amounts of Cr, Ni, and Co is used. In this study, Alloy1.4957 powders were sintered by hot isostatic pressing (HIP), and then homogenized and thermally exposed to exhaust gas temperatures. Then, a microstructural analysis was conducted to observe the changes that occurred for each process. M6X carbonitride containing Si, called Cr3Ni2SiX, was observed to be the main precipitate phase in this alloy. In general, it is known that Cr3Ni2SiX is only rarely observed in heat-resistant steel. However, in Alloy1.4957, a large amount of Cr3Ni2SiX was precipitated or dissolved depending on the process, and this is probably due to the high Si and N content of Alloy1.4957. In addition to Cr3Ni2SiX, Cr23C6 and NbX were observed. Cr23C6 was dissolved during the homogenization process, but NbX, which has high thermal stability, retained a fine size during the homogenization process and provided a nucleation site for Cr3Ni2SiX during thermal exposure.
Effect of Strain Rate on Deformation Behaviors of Ti-12.1Mo -1Fe Metastable Beta Alloy
Authors: Jin In Kyeong , Lee Dong-Geun
Published: September 2023

The addition of expensive elements to β titanium alloys, which are widely used in the aerospace and automobile industries, causes their price to increase. Low-cost, high-strength alloy (Ti-12.1Mo-1.0Fe) was designed in this study and the compressive behaviors of this alloy were evaluated for application to automobile parts, etc. As a result of ambient compression in the quasi-static and dynamic strain rate range (1×10-4/s~6×103/s), twinning occurred at all strain rates, and in particular, adiabatic shear bands were observed, which cause cracks and fractures under dynamic strain rate conditions. In addition, when the relationship between these bands and mechanical characteristics was evaluated, an increase of compression strength and Vickers hardness was confirmed to occur, due to the strain rate hardening effect under compression loading. Some twins were formed by the deformation behavior during compression plastic deformation of the Ti-12.1Mo-1.0Fe alloy, and it exhibited excellent compression strength characteristics, showing a very high strain rate hardening effect at a high strain rate.
The Effect of Ni Interlayer Formation Plating Bath on the Suppression of Oxidation of Ag-Coated Cu Flakes
Authors: Kim Ji Hwan , Lee Jong-Hyun
Published: September 2023

To suppress Ag dewetting from around 200 oC in Ag-coated Cu (Cu@Ag) flakes, Ag and Ni-coated Cu (Cu@Ni@Ag) flakes were fabricated by successive Ni and Ag electroless plating. The Ni bath type was an important consideration to induce differences in the Ag dewetting and resultant Cu oxidation. An acid Ni bath contained succinic acid as a complexing agent and sodium hypophosphite as a reductant, and an alkaline Ni bath contained sodium citrate as a complexing agent and sodium hydroxide as a pH adjuster as well as sodium hypophosphite. A hydrazine-based Ni bath contained sodium citrate, sodium hydroxide, and hydrazine hydrate as a reductant. The acid Ni bath provided amorphous coatings with a P content of approximately 10 wt%. The Cu@Ni@Ag flakes started the Ag dewetting and Cu oxidation at 350 oC, together with the formation of the Ni3P phase. Meanwhile, the alkaline Ni bath created Ni-5 wt% P amorphous Ni coatings, which transformed into a crystalline phase after heating at 350 oC. The Ag shell was dewetted at 450 oC, which caused oxidation of the flakes. Finally, the hydrazine-based Ni bath formed crystalline coatings without P, which induced rapid mixing with the core Cu. The Ag shells on the mixed Cu-Ni alloy showed repressed dewetting behavior, and thus the dewetting and oxidation temperature was the highest, such as 500 oC. Enhancing the high oxidation resistance at approximately 300 oC will enable the use of Cu@Ni@Ag flakes as a low-cost filler material in conductive pastes, especially for long-time or high-temperature curing.
Oxidation and TD-DFT of Toxic Acriflavine Hydrochloride Dye by Potassium Permanganate in Neutral Media: Kinetics and Removal of Dyes from Wastewater
Authors: Ibrahim Samia M. , Al-Hossainy Ahmed F. , Ali Hazim M. , Abd El Aal Mohamed , Farhan Nasser
Published: September 2023

Fabrication of dye thin films is accomplished through physical vapor deposition with a thickness of 150 ± 5 nm. Kinetically, the reduction of permanganate ion as a multi-equivalent oxidant by acriflavine hydrochloride (ACFH) in a neutral medium has been studied spectrophotometrically. In the presence of a pseudo-first-order reaction, the experimental results suggest fractional first-order kinetics in [ACFH] and a first-order dependency in [MnO4-]. The spectroscopic identification of intermediate species involving complexes of Mn (V) coordination has been examined along with a unique nitro-derivative-ACF (NDACF) synthesis. Based on the estimated activation values, which are in great agreement with the kinetic data obtained, oxidation reaction mechanism was postulated and described. The data exactly determine that ΔEgOpt the amount decreases from 1.566 eV for [ACFH]TF to 1.36 eV for [NDACF]TF for isolated molecules in the gaseous state utilizing TD-DFT model, HOMO and LUMO calculation. The improvements in kinetical and optical properties were achieved, and it is promising to use [NDACF]TF as solar cell application.
TAFSIR AHKAM REASONING FOR THE PROVISION OF CHILD CUSTODY AFTER DIVORCE IN ISLAM
Authors: Amin Habibi Al
Published: September 2023

The purpose of this study is to trace the legal reasoning for determining child custody in Islam. This research is a qualitative library research or normative juridical research. The technique used in analyzing the data in this study, using the descriptive-analytical method, to describe in general the laws and rules in Islam regarding child custody. The data of this research are classical Islamic fiqh books affiliated to the scholars of the four schools of fiqh, namely: Imam Maliki, Imam Hanafi, Imam Shafi'i and Imam Hanbali.
PERSPECTIVA DOS ALUNOS DO CURSO DE BACHARELADO EM MUSICOTERAPIA SOBRE A DISCIPLINA PIANO POPULAR
Authors: Figueiredo Camila Fernandes
Published: September 2023

O ensino tradicional do piano, fundamentado no modelo conservatorial, visa a aquisição de repertório e habilidades técnicas, pois o seu foco encontra-se no resultado, ou seja, na execução de uma obra musical. Por outro lado, o ensino do piano em grupo, neste caso, a disciplina Piano Popular, modalidade oferecida para estudantes com formação em outros instrumentos, busca desenvolver, pela prática do piano, habilidades funcionais que lhes forneçam uma base técnica para utilização na atuação profissional. Os objetivos especí­ficos desta pesquisa foram a) identificar as habilidades funcionais desenvolvidas na disciplina de piano popular do curso de Bacharelado em Musicoterapia e b) apresentar as perspectivas dos alunos com relação às aulas de piano. Para tanto, utilizou-se a metodologia de pesquisa avaliativa e a utilização de questionários para a coleta de dados. Participaram desta pesquisa 14 alunos da disciplina Piano Popular, os quais responderam questionários, aplicados no iní­cio e no término da disciplina. Os resultados apontaram que a disciplina Piano Popular pode auxiliar o aluno de musicoterapia em sua atuação profissional. Os alunos adquiriram, principalmente, habilidades de acompanhamento, leitura à primeira vista e leitura de cifras. As habilidades de improvisação musical, repertório e acompanhamento foram apontadas, pelos alunos, como relevantes na atuação do musicoterapeuta. A presente pesquisa contribuirá no âmbito das pesquisas em musicoterapia, na prática docente, apresentando propostas pedagógicas para o ensino do piano, e que podem ser aplicadas em outros instrumentos musicais presentes na grade curricular dos cursos de musicoterapia.
FATORES DE RISCO E DE PROTEÇÃO NO DESENVOLVIMENTO DA DEPRESSÃO: UMA ANÁLISE DO FILME CORINGA
Authors: Ambiel Gaigner Ana Claudia , Sapienza Graziela , Burko Rocha Chu Bruna
Published: September 2023

A depressão é um transtorno mental de alta prevalência, que traz sofrimentoe interfere na qualidade de vida do portador. Por ter caráter multicausal, resulta deuma combinação de diferentes fatores de risco. Sabe-se também que alguns fatorespodem ser protetivos ao seu desenvolvimento. O objetivo deste trabalho foi analisarestes fatores no desencadeamento da depressão do personagem do filme coringa, soba perspectiva da terapia cognitivo comportamental. A história envolve questões dasua infância, da dinâmica familiar, seus pensamentos, comportamentos e possíveiscrenças, bem como a terapia a qual foi submetido. Os temas foram agrupados ecomentados, articulando-se com o que já existe atualmente na literatura.
Corrected QTc interval combined with troponin value and mortality in acute ischemic stroke
Authors: Ahn Sung-Ho , Lee Ji-Sung , Yun Mi-sook , Han Jung-Hee , Kim Soo-Young , Lee Sang-Hyun , Park Min-Gyu , Park Kyung-Pil , Kang Dong-Wha , Kim Jong S. , Kwon Sun U.
Published: September 2023

Background and Purpose

Cardiac biomarkers including, elevated troponin (ET) and prolonged heart rate-corrected QT (PQTc) interval on electrocardiography are known to frequent and have a prognostic significance in patients with acute ischemic stroke (AIS). However, it is still challenging to practically apply the results for appropriate risk stratification. This study evaluate whether combining ET and PQTc interval can better assess the long-term prognosis in AIS patients.

Methods

In this prospectively registered observational study between May 2007 and December 2011, ET was defined as serum troponin-I ≥ 0.04 ng/ml and PQTc interval was defined as the highest tertile of sex-specific QTc interval (men ≥ 469 ms or women ≥ 487 ms).

Results

Among the 1,668 patients [1018 (61.0%) men; mean age 66.0 ± 12.4 years], patients were stratified into four groups according to the combination of ET and PQTc intervals. During a median follow-up of 33 months, ET (hazard ratio [HR]: 4.38, 95% confidence interval [CI]: 2.94–6.53) or PQTc interval (HR: 1.53, 95% CI: 1.16–2.01) alone or both (HR: 1.77, 95% CI: 1.16–2.71) was associated with increased all-cause mortality. Furthermore, ET, PQTc interval alone or both was associated with vascular death, whereas only ET alone was associated with non-vascular death. Comorbidity burden, especially atrial fibrillation and congestive heart failure, and stroke severity gradually increased both with troponin value and QTc-interval.

Conclusions

In patients with AIS, combining ET and PQTc interval on ECG enhances risk stratification for long-term mortality while facilitating the discerning ability for the burden of comorbidities and stroke severity.
The dimensionality of the epistemic orientation survey and longitudinal measurement invariance for the short form of EOS (EOS-SF)
Authors: Ding Chenchen , Fulmer Gavin , Hoffman Lesa , Hand Brian , Suh Jee K.
Published: September 2023

The dimensionality of the epistemic orientation survey (EOS) was examined across four occasions with item factor analysis (IFA). Because of an emphasis on the knowledge generation of epistemic orientation (EO), four factors were selected and built into a short form of EOS (EOS-SF) including knowledge generation, knowledge replication, epistemic nature of knowledge, and student ability. To track the stability of the factor structure for each factor of EOS-SF, longitudinal invariance models were conducted. Partial measurement invariance was obtained for each of the four factors of EOS-SF. This study provides an example of ongoing instrument development in the field of applied assessment research.
Intensity-modulated radiotherapy for cushing’s disease: single-center experience in 70 patients
Authors: Lian Xin , Xu Zhuoran , Sun Shuai , Wang Weiping , Zhu Huijuan , Lu Lin , Hou Xiaorong , Zhang Fuquan
Published: September 2023

Context

Intensity-modulated radiotherapy (IMRT) is a modern precision radiotherapy technique for the treatment of the pituitary adenoma.

Objective

Aim to investigate the efficacy and toxicity of IMRT in treating Cushing’s Disease (CD).

Methods

70 of 115 patients with CD treated with IMRT at our institute from April 2012 to August 2021 were included in the study. The radiation doses were usually 45-50 Gy in 25 fractions. After IMRT, endocrine evaluations were performed every 6 months and magnetic resonance imaging (MRI) annually. Endocrine remission was defined as suppression of 1 mg dexamethasone test (DST) or normal 24-hour urinary free cortisol level (24hUFC). The outcome of endocrine remission, endocrine recurrence, tumor control and complications were retrieved from medical record.

Results

At a median follow-up time of 36.8 months, the endocrine remission rate at 1, 2, 3 and 5 years were 28.5%, 50.2%, 62.5% and 74.0%, respectively. The median time to remission was 24 months (95%CI: 14.0-34.0). Endocrine recurrence was found in 5 patients (13.5%) till the last follow-up. The recurrence-free rate at 1, 2, 3 and 5 years after endocrine remission was 98.2%, 93.9%, 88.7% and 88.7%, respectively. The tumor control rate was 98%. The overall incidence of new onset hypopituitarism was 22.9%, with hypothyroidism serving as the most common individual axis deficiency. Univariate analysis indicated that only higher Ki-67 index (P=0.044) was significant favorable factors for endocrine remission.

Conclusion

IMRT was a highly effective second-line therapy with low side effect profile for CD patients. Endocrine remission, tumor control and recurrence rates were comparable to previous reports on FRT and SRS.
Alveolar macrophages in lung cancer: opportunities and challenges
Authors: Chang Cheng-Yen , Armstrong Dominique , Corry David B. , Kheradmand Farrah
Published: September 2023

Alveolar macrophages (AMs) are critical components of the innate defense mechanism in the lung. Nestled tightly within the alveoli, AMs, derived from the yolk-sac or bone marrow, can phagocytose foreign particles, defend the host against pathogens, recycle surfactant, and promptly respond to inhaled noxious stimuli. The behavior of AMs is tightly dependent on the environmental cues whereby infection, chronic inflammation, and associated metabolic changes can repolarize their effector functions in the lungs. Several factors within the tumor microenvironment can re-educate AMs, resulting in tumor growth, and reducing immune checkpoint inhibitors (ICIs) efficacy in patients treated for non-small cell lung cancer (NSCLC). The plasticity of AMs and their critical function in altering tumor responses to ICIs make them a desirable target in lung cancer treatment. New strategies have been developed to target AMs in solid tumors reprograming their suppressive function and boosting the efficacy of ICIs. Here, we review the phenotypic and functional changes in AMs in response to sterile inflammation and in NSCLC that could be critical in tumor growth and metastasis. Opportunities in altering AMs’ function include harnessing their potential function in trained immunity, a concept borrowed from memory response to infections, which could be explored therapeutically in managing lung cancer treatment.
Increased carotid intima–media thickening and antioxidized low-density lipoprotein in an anti-Ro60 SLE autoantibody subset
Authors: Kurien Biji T. , Fesmire James , Nath Swapan K. , Scofield R. Hal
Published: September 2023

Objective

Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). We have previously shown an association of anti-Ro60/La/Ro52 with antioxidized low-density lipoprotein (LDL) in SLE. Here, we hypothesized that carotid intima–media thickening (CIMT) would be associated with antioxidized LDL (anti-oxLDL)/antilipoprotein lipase (ALPL) in a specific SLE autoantibody subset (anti-Ro60 positive, anti-RNP positive, anti-SmRNP positive, or extractable nuclear antigen antibody negative).

Methods

We carried out a case-control study (one time-point testing) of CIMT, ALPL, anti-oxLDL, anti-low density lipoprotein (ALDL), and anti-LDL in 114 SLE patients and 117 age/sex-matched controls. The levels of total cholesterol, LDL, high-density lipoprotein (HDL), triglycerides, and HDL-Trig were also measured. A student's t-test was used for statistical analysis.

Results

Interestingly, the level of CIMT was highest in the SLE subset with anti-Ro60 (23/114). CIMT and anti-oxLDL were statistically significantly elevated in the anti-Ro60 SLE subset (1.3 ± 1.66, p < 0.01; 0.26 ± 0.16, p < 0.002, respectively) compared with controls (0.54 ± 1.26; 0.165 ± 0.13, respectively), but not anti-LPL/anti-LDL. CIMT was significantly elevated (0.9 ± 1.71; p < 0.05) in the SLE subset without antiextractable nuclear antigen (ENA) (63/114) compared with controls. The other antibodies in this subset were not statistically different from other SLE subsets or controls. Only antioxLDL was significantly elevated (0.29 ± 0.27; p < 0.005) in the SLE subset with anti-RNP (14/114) compared with controls, while none were elevated in the anti-SmRNP subset (6/114). We did not find any significant differences in lipids between the various SLE subsets.

Conclusion

CIMT segregates in anti-Ro and ENA negative groups either with or without anti-oxLDL. It will be clinically important if cardiovascular events are augmented in the SLE anti-Ro subset having elevated antioxidized LDL antibodies.
Macroalgal forest restoration: the effect of the foundation species
Authors: Bianchelli Silvia , Fraschetti Simonetta , Martini Francesco , Lo Martire Marco , Nepote Ettore , Ippoliti Davide , Rindi Fabio , Danovaro Roberto
Published: September 2023

Introduction

Active restoration is the strategy needed to trigger or accelerate the recovery of degraded marine habitats, which provide the goods and services essential for preserving biodiversity and human wellbeing. Ecosystem engineers are generally the target species in the ecological restoration of marine ecosystems, and large-sized brown macroalgae (e.g., the Cystoseira complex) are a priority due to their crucial ecological importance and vulnerability in many regions of the Mediterranean Sea.

Methods

Here, we present the results of a successful intervention of ecological restoration of Gongolaria barbata.

Results and Discussion

One year after the restoration intervention, we observed the recovery of the canopy in terms of ca. 15m2 with a significant increase in faunal abundance and biodiversity compared with reference areas. However, despite the high restored macroalgal growth rates, the assemblage structure was still significantly different from that of reference pristine areas. Despite the fast faunal colonization of a new 3D habitat linked to the successful re-introduction of the ecosystem engineers (i.e., macroalgae), the complete restoration of the properties of a habitat can be a much longer process. We conclude that, after 1 year, active restoration of macroalgal forests still results in a partial recovery of ecosystem functions (i.e., rehabilitation) rather than a full ecosystem restoration, thus stressing the need for long-term monitoring of restoration interventions.
Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort – extension of the LONG-PD study
Authors: Chase Bruce A. , Krueger Rejko , Pavelka Lukas , Chung Sun Ju , Aasly Jan , Dardiotis Efthimios , Premkumar Ashvini P. , Schoneburg Bernadette , Kartha Ninith , Aunaetitrakul Navamon , Frigerio Roberta , Maraganore Demetrius , Markopoulou Katerina
Published: September 2023

Background

The severity, progression, and outcomes of motor and non-motor symptoms in Parkinson’s disease (PD) are quite variable. Following PD cohorts holds promise for identifying predictors of disease severity and progression.

Methods

PD patients (N = 871) were enrolled at five sites. Enrollment occurred within 5 years of initial motor symptom onset. Disease progression was assessed annually for 2-to-10 years after onset. Group-based trajectory modeling was used to identify groups differing in disease progression. Models were developed for UPDRS-III scores, UPDRS-III tremor and bradykinesia-rigidity subscores, Hoehn & Yahr (H&Y) stage, Mini-Mental Status Exam (MMSE) scores, and UPDRS-III, H&Y and MMSE scores considered together. Predictors of trajectory-group membership were modeled simultaneously with the trajectories. Kaplan–Meier survival analysis evaluated survival free of PD outcomes.

Results

The best fitting models identified three groups. One showed a relatively benign, slowly progressing trajectory (Group 1), a second showed a moderate, intermediately progressing trajectory (Group 2), and a third showed a more severe, rapidly progressing trajectory (Group 3). Stable trajectory-group membership occurred relatively early in the disease course, 5 years after initial motor symptom. Predictors of intermediate and more severe trajectory-group membership varied across the single variable models and the multivariable model jointly considering UPDRS-III, H&Y and MMSE scores. In the multivariable model, membership in Group 2 (28.4% of patients), relative to Group 1 (50.5%), was associated with male sex, younger age-at-onset, fewer education-years, pesticide exposure, absence of reported head injury, and akinetic/rigid subtype at initial presentation. Membership in Group 3 (21.3%), relative to Group 1, was associated with older age-at-onset, fewer education-years, pesticide exposure, and the absence of a tremor-predominant subtype at initial presentation. Persistent freezing, persistent falls, and cognitive impairment occurred earliest and more frequently in Group 3, later and less frequently in Group 2, and latest and least frequently in Group 1. Furthermore, autonomic complications, dysphagia, and psychosis occurred more frequently in Groups 2 and 3 than in Group 1.

Conclusion

Modeling disease course using multiple objective assessments over an extended follow-up duration identified groups that more accurately reflect differences in PD course, prognosis, and outcomes than assessing single parameters over shorter intervals.
Case report: Recurrent pontine stroke and leukoencephalopathy in a patient with de novo mutation in COL4A1
Authors: Zhang Hui , Fan Kai-Li , Zhang Yue-Qi , Hao Xiao-Yan , Yuan Xiang-Zhen , Zhang Shu-Yun
Published: September 2023

This report presents a case of pontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL) in a 35 year-old male patient. The patient exhibited a consistent history of recurrent ischemic strokes, concentrated primarily in the pons region, accompanied by concurrent manifestations of leukoencephalopathy and microbleeds. Genetic evaluation revealed a heterozygous missense mutation consistent with c.3431C>G, p. Thr1144Arg substitution within exon 40 of the COL4A1 gene. This mutation was also identified in the patient’s mother, affirming an autosomal dominant inheritance model. Our findings serve as testament to the potential role of mutation in the exon 40 of COL4A1 in the pathogenesis and progression of PADMAL, contributing to ongoing efforts aimed at better understanding the genetic basis of this debilitating disorder.
Associations between migraine and possible risk factors in the Czech Republic
Authors: Riedlova Petra , Zahradnikova Barbora , Skybova Dagmar , Slachtova Hana , Jirik Vitezslav , Tomaskova Hana
Published: September 2023

Introduction

Migraine is a widespread neurological disorder, growing increasingly common. However, the pathogenesis of the disease is often unclear and the evidence for the role of various risk factors is limited. This study aimed to identify risk factors associated with migraine and to contribute towards a better understanding of this disease.

Methods

Data from 3,247 questionnaires were analyzed for associations between migraine and sex, age, BMI, degree of education, and air pollution, along with other factors such as contact with friends, physical condition, health, anxiety, and depression. A cross-sectional study was conducted with an approximately equal distribution of the sample by age, gender and two analysed regions. Data were presented using basic descriptive statistics using the chi-square test. The model output was presented using a crude odds ratio (OR) and a fully adjusted OR. Three hundred and eight-six individuals (12%) suffered from migraine.

Results

In an adjusted model, the presented study found associations between the prevalence of migraine and sex, age, and level of education. Individuals with migraine statistically significantly more often suffered from depression, anxiety and other selected factors. However, the assumed significant association between the occurrence of migraine and pollution in the region has not been found
Construction of a prognostic model for colorectal adenocarcinoma based on Zn transport-related genes identified by single-cell sequencing and weighted co-expression network analysis
Authors: Chen Hua , Zhao Ting , Fan Jianing , Yu Zhiqiang , Ge Yiwen , Zhu He , Dong Pingping , Zhang Fu , Zhang Liang , Xue Xiangyang , Lin Xiaoming
Published: September 2023

Background

Colorectal cancer (CRC) is one of the most prevalent malignancies and the third most lethal cancer globally. The most reported histological subtype of CRC is colon adenocarcinoma (COAD). The zinc transport pathway is critically involved in various tumors, and its anti-tumor effect may be through improving immune function. However, the Zn transport pathway in COAD has not been reported.

Methods

The determination of Zn transport-related genes in COAD was carried out through single-cell analysis of the GSE 161277 obtained from the GEO dataset. Subsequently, a weighted co-expression network analysis of the TCGA cohort was performed. Then, the prognostic model was conducted utilizing univariate Cox regression and least absolute shrinkage and selection operator (LASSO) Cox regression analysis. Functional enrichment, immune microenvironment, and survival analyses were also carried out. Consensus clustering analysis was utilized to verify the validity of the prognostic model and explore the immune microenvironment. Ultimately, cell experiments, including CCK-8,transwell and scratch assays, were performed to identify the function of LRRC59 in COAD.

Results

According to the Zn transport-related prognostic model, the individuals with COAD in TCGA and GEO databases were classified into high- and low-risk groups. The group with low risk had a comparatively more favorable prognosis. Two groups had significant variations in the immune infiltration, MHC, and the expression of genes related to the immune checkpoint. The cell experiments indicated that the proliferation, migration, and invasion of the HCT-116, DLD-1, and RKO cell lines were considerably increased after LRRC59 knockdown. It proved that LRRC59 was indeed a protective factor for COAD.

Conclusion

A prognostic model for COAD was developed using zinc transport-related genes. This model can efficiently assess the immune microenvironment and prognosis of individuals with COAD. Subsequently, the function of LRRC59 in COAD was validated via cell experiments, highlighting its potential as a biomarker.
Circadian rhythm disorders in patients with advanced cancer: a scoping review
Authors: Gouldthorpe Craig , Power Jenny , Davies Andrew
Published: September 2023

Circadian rhythms can be demonstrated in several biomarkers and behavioural activities, with rhythmical patterns occurring roughly over a 24-h period. Circadian disorders occur in patients with cancer and may be associated with poor clinical outcomes. This scoping review aimed to identify circadian rhythm research and reporting practices, circadian rhythm patterns, circadian rhythm disorders, and relevant associations of circadian rhythm disorders in patients with advanced cancer. Studies involved adult patients with locally advanced or metastatic cancer and used objective measures of circadian rhythmicity. Two independent authors completed initial screening of title and abstracts, full text reviews, data extraction, and data checking. A total of 98 articles were highlighted in the scoping review, which utilised physical activity measures (actigraphy and polysomnography), biomarkers (cortisol and melatonin), or a combination. Several circadian rhythms are commonly disordered amongst patients with advanced cancer and have significant implications for symptom burden, quality of life, and survival. It remains unclear which patients are most at risk of a circadian rhythm disorder. Significant heterogeneity exists in research and reporting practices. Standardising this approach may address discrepancies in the current literature and allow for research to focus on the most relevant parameters and approaches to improving circadian rhythmicity.