bluuebunny/crossref_metadata_2025 huggingface dataset:
Wettability of Tight Sandstone Reservoir and Its Impacts on the Oil Migration and Accumulation: A Case Study of Shahejie Formation in Dongying Depression, Bohai Bay Basin
Authors: Jia Kunkun , Zeng Jianhui , Wang Xin , Li Bo , Gao Xiangcheng , Wang Kangting
Published: June 2022

The migration and accumulation of oil in tight sandstone reservoirs are mainly controlled by capillary force. Due to the small pore radius and complex pore structure of tight sandstone reservoirs, the capillary force is very sensitive to wettability, so wettability significantly affects oil migration and accumulation. However, the study of oil migration and accumulation in tight sandstone reservoirs often needs to combine multiple methods, the process is complex, and the research methods of wettability are not uniform, so the mechanism of wettability affecting oil migration and accumulation is not clear. Taking the tight sandstone of the Shahejie Formation in the Dongying sag, Bohai Bay Basin, as the research object, the wettability characteristics of a tight sandstone reservoir and their influence on oil migration and accumulation were analyzed by means of a pore permeability test, XRD analysis, micro-CT experiment, contact angle tests, spontaneous imbibition experiments, and physical simulation experiments on oil migration and accumulation. The results show that the reservoir is of the water-wet type, and its wettability is affected by the mineral composition. Wettability in turn affects the spontaneous imbibition characteristics by controlling the capillary force. Oil migration in tight sandstone reservoirs is characterized by non-Darcy flow, the oil is in the non-wetting phase and subject to capillary resistance. The key parameters to describe the oil migration and accumulation characteristics include the kickoff pressure gradient, the critical pressure gradient, and ultimate oil saturation. Wettability affects oil migration characteristics by controlling the capillary force. The more oil-wet the reservoir is, the more favourable it is to oil migration and oil accumulation and therefore the higher the reservoir’s ultimate oil saturation is.
Economics of Implementing Solar Thermal Heating Systems in the Textile Industry
Authors: Kumar Pankaj , Sinha Krishna Kumar , Đurin Bojan , Gupta Mukesh Kumar , Saxena Nishant , Banerjee Malay Kumar , Kranjčić Nikola , Singh Suraj Kumar , Kanga Shruti
Published: June 2022

This paper analyzes the potential of solar thermal systems for being employed for process heating in cotton-based textile industries. The technological capability of a flat plate collector (FPC) to meet the solar industrial process heating (SIPH) requirement in yarn production is assessed. Moreover, the usability of a parabolic trough collector (PTC) in meeting the technological mandates of SIPH in fabric processing units is critically examined. Further, this paper reports the findings of a study on the potential cost advantage of solar process heating over the conventional process heating practices in cotton-based textile industries. The approach involves the selection of the locations of sample textile industries and the employable solar collector technologies, as well as assessment of financial reward, if any. Eight different cotton-based textile industries located in different geographical domains (in India) are selected. The selected textile industries are situated within the textile hubs existing in different states across India. Analysis of technoeconomic benefit derivable in selected textile industries using FPC for hot water generation and PTC for steam generation is presented. In the case of FPC-based SIPH systems, the maximum value of solar fraction is estimated to be 0.30 and the corresponding estimation for the levelized cost of useful thermal energy (LCUTE) delivered comes out as INR 790/GJ to INR 1020/GJ. On the other hand, in case of parabolic-trough-solar-concentrator-based SIPH systems, LCUTE is estimated in the range of INR 1030/GJ to INR 1610/GJ. From a critical analysis of financial viability in consideration of related factors such as payback time and return on investment in SIPH, it appears that the SIPH systems for hot water generation may be a good choice, whereas SIPH systems for steam generation are seen to have longer payback periods and lower returns on investment, and, therefore, it seems that adequate financial support from central and state governments with additional supports from bilateral or multilateral organizations may enable them to become a sustainable technology option.
The Human Passion for Music
Authors: Grinde Bjørn
Published: June 2022

Music is a universal feature of human societies, which suggests that an evolutionary perspective should help us understand our appreciation. The reward (pleasure) system of the brain offers a suitable framework. The question is why we evolved rewards for listening to and producing sounds with particular qualities. The primary evolutionary advantage is probably related to the importance of language; features of sound, such as purity, harmony, complexity, and rhythmicity, are useful for facilitating oral communication. One would expect evolution to associate rewards with these qualities in order to stimulate the development of brain regions involved in interpreting and producing relevant sounds. There are additional adaptive aspects of music, such as relaxation, social coherence, and sexual selection. Music can be regarded as a superstimulus that accentuates and exploits rewards associated with hearing. As such, music is not necessarily adaptive in a biological sense, but serves the purpose of improving quality of life.
The Applications of Microphysiological Systems in Biomedicine: Impact on Urologic and Orthopaedic Research
Authors: Caetano-Pinto Pedro , Schoon Janosch
Published: June 2022

Microphysiological systems (MPSs) are in vitro models that can incorporate dynamic stimuli such as flow, pressure and contraction in cell culture, enabling the formation of cellular architectures and retrieving physiological function often absent in conventional 2D-cell culture. MPS applications saw a substantial growth in recent years, drawing attention from industry as a strategy to optimize pre-clinical drug-development purposes, as well as from biomedical research, to fill a gap between in vivo and in vitro models. Several MPS platforms are now available and are employed in the development of bone and kidney complex systems for urologic and orthopaedic research. These advances have enabled, for example, the in vitro modelling of bone regeneration and renal drug secretion, and have dramatic potential to improve research into both orthopaedic and urology cancers.
A Review of Prader–Willi Syndrome
Authors: Szabadi Stephen , Sila Zachary , Dewey John , Rowland Dustin , Penugonda Madhuri , Ergun-Longmire Berrin
Published: June 2022

Prader–Willi Syndrome (PWS, OMIM #176270) is a rare complex genetic disorder due to the loss of expression of paternally derived genes in the PWS critical region on chromosome 15q11-q13. It affects multiple neuroendocrine systems and may present failure to thrive in infancy, but then, hyperphagia and morbid obesity starting in early childhood became the hallmark of this condition. Short stature, hypogonadism, sleep abnormalities, intellectual disability, and behavioral disturbances highlight the main features of this syndrome. There have been a significant number of advances in our understanding of the genetic mechanisms underlying the disease, especially discoveries of MAGEL2, NDN, MKRN3, and SNORD116 genes in the pathophysiology of PWS. However, early diagnosis and difficulty in treating some of the disease’s most disabling features remain challenging. As our understanding of PWS continues to grow, so does the availability of new therapies and management strategies available to clinicians and families.
Functional Traits of Quercus aliena var. acuteserrata in Qinling Huangguan Forest Dynamics Plot: The Relative Importance of Plant Size and Habitat
Authors: Qiu Jing , Han Anxia , He Chunmei , Dai Xiaoxia , Jia Shihong , Luo Ying , Hao Zhanqing , Yin Qiulong
Published: June 2022

Variation in intraspecific functional traits is one of the important components of community variation, and has drawn the attention of researchers. Studying the variation of traits under different plant sizes and habitats helps to reveal the adaptation mechanism of plants. We explored intraspecific trait variations by focusing on the widespread species Quercus aliena var. acuteserrata in a 25 ha warm, temperate, deciduous broadleaved forest plot in the Qinling Mountains. We measured nine morphological and chemical traits for 90 individuals from different plant sizes and habitats. In addition, we evaluated the relative impact of plant size and environment on Q. aliena var. acuteserrata with multiple regression models. We found that plant size explained the most variance of traits. As plant size increased, the trees tended to have lower leaf nitrogen concentrations, lower leaf phosphorus concentrations, higher leaf carbon concentrations, higher leaf dry matter content (LDMC), and thinner leaves, indicating the transformation from rapid resource acquisition strategy to conservative resource-use strategy. Habitats could only explain the changes in chemical traits. Leaf carbon concentration was principally affected by topographical factors and was significant different among habitats. Leaf nitrogen concentration and LPC were significantly limited by soil N and P. In conclusion, shifts in size-dependent traits met the growth requirements of Q. aliena var. acutiserrata; the high tolerance traits associated with this tree species might elucidate important mechanisms for coping with changing environments.
Use of Hydrological Models to Predict Risk for Rutting in Logging Operations
Authors: Mohtashami Sima , Thierfelder Tomas , Eliasson Lars , Lindström Göran , Sonesson Johan
Published: June 2022

Using hydrological models with a high temporal resolution to predict risk for rutting may be a possible method to improve planning of forwarder trails or to schedule logging operations in sites with low bearing capacity to periods when soil moisture content is at a minimum. We have studied whether descriptions of rut variations, collected in 27 logging sites, can be improved by using hydrological data, modeled by Swedish HYdrological Prediction for Environment (S-HYPE). Other explanatory variables, such as field-surveyed data and spatial data, were also used to describe rut variations within and across logging sites. The results indicated that inclusion of S-HYPE data led to only marginal improvement in explaining the observed variations of the ruts in terms of both “rut depths” within the logging sites and “proportion of forwarder trails with ruts” across the logging sites. However, application of S-HYPE data for adapting depth-to-water (DTW) maps to temporal changes of soil moisture content may be a way to develop more dynamic soil moisture maps for forestry applications.
Larval Instars and Adult Flight Period of Monochamus saltuarius (Coleoptera: Cerambycidae)
Authors: Fan Lichun , Wang Jue , Wang Weitao , Zheng Yanan
Published: June 2022

Monochamus saltuarius is a vector of Bursaphelenchus xylophilus in Japan, South Korea, and the middle temperate zone of China. However, there are only a few reports on this species in China, and its biological characteristics are still unclear. In this study, we aimed to elucidate the larval development and adult flight period of M. saltuarius to provide a theoretical basis for the effective control of pine wilt disease in the middle temperate zone of China. Seven morphological variables of larvae were measured to determine the number of larval instars, and the adult specimens of M. saltuarius were collected from traps in forests to study the flight period of adults in Fushun, Liaoning, the epidemic center of pine wilt disease in the middle temperate zone of China. The results revealed that the full larval period of M. saltuarius was 279.6 d, and the larvae had five instar stages, with an average duration of 7.4, 14.3, 49.8, 83.6, and 124.5 d, respectively. Additionally, 78.4% of the overwintering larvae were fourth instar, and 21.6% were fifth instar larvae. We also found that the adults began to emerge from early May to late June, and the period was from early May to mid-August in the forest. During the investigations period from 2018 to 2020, the total number of adults captured was minimal at 744, and precipitation was highest at 291.54 mm in 2019. We characterized the larval instars and adult flight period of M. saltuarius, which is a prerequisite for developing appropriate management strategies. The results of this study will provide an important reference for the formulation of strategies to control M. saltuarius and pine wilt disease.
Assessing the Stock Dynamics of Elasmobranchii off the Southern Coast of Sicily by Using Trawl Survey Data
Authors: Falsone Fabio , Gancitano Vita , Geraci Michele Luca , Sardo Giacomo , Scannella Danilo , Serena Fabrizio , Vitale Sergio , Fiorentino Fabio
Published: June 2022

Elasmobranchii (sharks and rays), which have peculiar and vulnerable life-history traits, are highly threatened by fishing activities. Indeed, between 53% and 71% of Mediterranean elasmobranch species are at risk of extinction. In this context, using the abundance MSY (AMSY) model, the present study provides an assessment of 20 batoids and 16 shark species in the Strait of Sicily, sampled during a bottom trawl survey from 1995 to 2020. Overall, the outputs underline a progressively improving condition for shark and ray assemblages of both shelf and eurybathic zones. As for slope-dwelling species, a horseshoe-shaped dynamic, characterized by a progressive decrease in relative harvesting pressure and an increase in relative biomass followed by an increase in fishing pressure and decrease in biomass, was detected. The dynamics of the Elasmobranchii living in the Strait of Sicily appear to be affected by changes in the fishing patterns of trawlers, showing a shift from shallow water to bathyal fishing grounds and targeting deep-water red shrimp. In this context, it seems wise to limit the impact of deep-water fisheries on Elasmobranchii by reducing fishing efforts and implementing ad hoc management measures aimed at safeguarding these vulnerable species.
Carotenoid Profiling of Yellow-Flesh Peach Fruit
Authors: Zhao Bintao , Sun Meng , Li Jiyao , Su Ziwen , Cai Zhixiang , Shen Zhijun , Ma Ruijuan , Yan Juan , Yu Mingliang
Published: June 2022

In this study, the carotenoid profiles and content in 132 cultivars of yellow-flesh peach having different fruit developmental periods (short, middle, and long), fruit surface indumenta (glabrous and pubescent skin), and flesh colors (yellow, golden, and orange) were investigated. We simultaneously analyzed and compared the levels of five carotenoids (lutein, zeaxanthin, β-cryptoxanthin, α-carotene, and β-carotene) through high-performance liquid chromatography. Large differences in carotenoid content among germplasms were observed, with coefficients of variation ranging from 21.24% to 67.78%. The carotenoid content, from high to low, was as follows: β-carotene > zeaxanthin > α-carotene > β-cryptoxanthin > lutein. We screened several varieties with high carotenoid content, including zeaxanthin in ‘Ruiguang2’, β-cryptoxanthin in ‘NJN76’ and ‘TX4F244C’, and β-carotene and total carotenoids in ‘Jintong7’, ‘77-26-7’, and ‘77-20-5’. A longer fruit developmental period was associated with greater β-carotene accumulation but lowered the zeaxanthin and β-cryptoxanthin accumulation. The zeaxanthin, β-carotene, and total carotenoid concentrations significantly increased as the flesh color deepened, but the lutein and α-carotene levels remained similar among the three flesh colors. The classification index of the indumenta significantly affected the β-carotene and total carotenoid content (p < 0.05) and was higher in pubescent than glabrous skin.
Consumers’ Preferences for the Traceability Information of Seafood Safety
Authors: Hoque Mohammed Ziaul , Akhter Nazmoon , Chowdhury Mohammad Shafiur Rahman
Published: June 2022

Due to importing food and the perpetual changes from conventional wet markets to supermarkets in emerging markets, consumers have the opportunity to base their buying decisions on traceability systems. Seafood traceability systems involve information on production mode, inspection notes, sustainable sources, and sources of origin to provide consumer protection and help ensure that all seafood is safe to consume. This study aims to explore seafood markets by assessing the demand for traceability information attributes by utilising data from an experimental survey in an emerging market such as Bangladesh. The data were analysed using descriptive statistics, exploratory factor analysis, and a conditional logit model. The results demonstrate that consumers are concerned regarding vitamins, cholesterol, and preservatives, while they are little concerned about microbiological contamination, pesticide residues, genetic modification, and additives or artificial colours. The difference between the mean willingness to pay (WTP) for traditional and sustainable farmed fish is higher than that between the mean WTP for conventional and sustainable wild fish. In a ranked-choice voting system, the ‘production mode’ and ‘claim of safety control (e.g., being formalin-free)’ were the first and second most influential attributes in fish choices. The outcomes of the econometric model revealed that consumers are more likely to prefer traceability information about fish control (e.g., formalin-free), and they want to pay a price premium for this information. Alternatively, consumers are less likely to prefer farmed and imported fish, and their WTP for these fishes are highly inflated. This finding may be because consumers use wild and local origin as a cue for food safety or quality. This study hopes that the effects of such traceability information will optimise the production process and supply chain and help make seafood recall management more effective.
CE–RAA–CRISPR Assay: A Rapid and Sensitive Method for Detecting Vibrio parahaemolyticus in Seafood
Authors: Lv Xinrui , Cao Weiwei , Zhang Huang , Zhang Yilin , Shi Lei , Ye Lei
Published: June 2022

Vibrio parahaemolyticus is one of the major pathogenic Vibrio species that contaminate seafood. Rapid and accurate detection is crucial for avoiding foodborne diseases caused by pathogens and is important for food safety management and mariculture. In this study, we established a system that combines chemically enhanced clustered regularly interspaced short palindromic repeats (CRISPR) and recombinase-aided amplification (RAA) (CE–RAA–CRISPR) for detecting V. parahaemolyticus in seafood. The method combines RAA with CRISPR-associated protein 12a (Cas12a) for rapid detection in a one-pot reaction, effectively reducing the risk of aerosol contamination during DNA amplifier transfer. We optimized the primers for V. parahaemolyticus, determined the optimal crRNA/Cas12a ratio, and demonstrated that chemical additives (bovine serum albumin and L-proline) could enhance the detection capacity of Cas12a. The limit of detection (at optimal conditions) was as low as 6.7 × 101 CFU/mL in pure cultures and 7.3 × 101 CFU/g in shrimp. Moreover, this method exhibited no cross-reactivity with other microbial pathogens. The CE–RAA–CRISPR assay was compared with the quantitative polymerase chain reaction assay using actual food samples, and it showed 100% diagnostic agreement.
Investigation on the Microbial Diversity of Fresh-Cut Lettuce during Processing and Storage Using High Throughput Sequencing and Their Relationship with Quality
Authors: Sun Yeting , Zhao Xiaoyan , Ma Yue , Ma Zhihong , He Zhaoying , Zhao Wenting , Wang Pan , Zhao Shuang , Wang Dan
Published: June 2022

Microbial community distribution in vegetables can affect their quality. This study analyzed the distribution of the microbial community at various stages during processing and storage with the microbial diversity analysis, and evaluated the correlation between the dominant bacteria and sensory quality of lettuce using correspondence analysis with multiple regression analysis. Results showed that the process of washing, cutting, then disinfection and dewatering could change the community distribution and dominant bacteria in lettuce, and maintain better texture, morphology, aroma, color qualities of lettuce. The total number of colonies and relative abundance of Xanthomonas in fresh-cut lettuce decreased, while Afipia and Ralstonia increased during processing and pre-storage (storage for 6 h, 12 h and 1 d). After storage for 3 d, the total number of colonies in lettuce increased (more than 5 log CFU/g), especially the relative abundance of Pseudomonas, which led to the obvious deterioration of the sensory quality of lettuce. Throughout the process, the number of Bacillus cereus, Staphylococcus aureus, and E. coli was less than 100 CFU/g and 3 MPN/g. The number of typical pathogenic bacteria, Salmonella, Listeria monocytogenes and E. coli O157:H7, was below the detection limit. Overall, the prevention and control of psychrotrophic Pseudomonas in lettuce was still necessary. These results will provide useful information for the fresh-cut lettuce industry.
Impact of Acetaldehyde Addition on the Sensory Perception of Syrah Red Wines
Authors: Garcia Luca , Perrin Cédrine , Nolleau Valérie , Godet Teddy , Farines Vincent , Garcia François , Caillé Soline , Saucier Cédric
Published: June 2022

Two experimental Syrah red wines with different polyphenol contents were used to study the impact of acetaldehyde addition on olfactory perception. Free acetaldehyde levels were measured in red wine by Head Space-Gas Chromatography-Mass Spectrometry (HS-GC-MS) to determine the acetaldehyde combination levels for those wines. Significant differences were observed for both sensory threshold and acetaldehyde combination for the wines. A descriptive sensory analysis of the wines was then performed by using a trained panel and a Hierarchical-Check-All-That-Apply (HCATA) analysis of the wines with or without acetaldehyde addition. The results show that classical cited sensory descriptors for acetaldehyde (overripe apple and oxidized apple) varied significantly between the control wines and those with acetaldehyde addition. Non-acetaldehyde related descriptors (fresh vegetable, fresh flowers, cocoa, and meat juice) were also significantly impacted in the samples with increasing acetaldehyde additions. This suggests possible interactions between acetaldehyde and other volatile compounds that can create antagonistic or synergistic effects between the molecules or at the olfactory receptor level.
Differential Nutrition-Health Properties of Ocimum basilicum Leaf and Stem Extracts
Authors: Bensaid Aicha , Boudard Frederic , Servent Adrien , Morel Sylvie , Portet Karine , Guzman Caroline , Vitou Manon , Bichon Florence , Poucheret Patrick
Published: June 2022

(1) Background: Ocimum basilicum L. is an aromatic medicinal plant of the Lamiaceae family known as sweet basil. It is used in traditional medicine for its beneficial effects on gastrointestinal disorders, inflammation, immune system, pyrexia or cancer among others. Ocimum basilicum (OB) leaf extracts contain many phytochemicals bearing the plant health effects but no reports is available on the potential bioactivity of stem extracts. Our investigation aimed at assessing the differential biological activity between basil leaf and stem to promote this co-product valorization. (2) Method: For this purpose we explored phytochemical composition of both parts of the plant. Antioxidant activity was evaluated through total polyphenol content measure, DPPH and ORAC tests. Anti-inflammatory markers on stimulated macrophages, including NO (nitric oxide), TNFa (tumor necrosis factor alpha), IL-6 (interleukin 6), MCP1 (monocyte attractant protein 1) and PGE-2 (prostaglandin E2), were evaluated. In addition, we investigated OB effects on jejunum smooth muscle contractility. (3) Results: OB extracts from leaves and stems demonstrated a different biological activity profile at the level of both antioxidant, anti-inflammatory and smooth muscle relaxation effects. (4) Conclusion: Taken together our results suggest that Ocimum basilicum extracts from co-product stems, in addition to leaves, may be of interest at the nutrition-health level with specific therapeutic potential.
Histopathological and Quantitative Lesions of the Cardiac Conduction System and Its Vascularization Related to Chronic Cocaine Abusers and Sudden Unexpected Death
Authors: Sánchez-Quintana Damián , Alama Sergio , Macías Yolanda , Cabrera José-Ángel , Santos María , Salguero Manuel
Published: June 2022

Cocaine abuse is associated with multiple cardiovascular events, including myocardial infarction, arrhythmias, and sudden death. A total of 40 hearts were studied. The purpose of this study was to compare the cardiac conduction tissue and its vascularization in 20 young adults without a history of drug use and/or arrhythmias and 20 hearts of young adults with a history of chronic cocaine use who have died of sudden unexpected death, in which toxicological analyzes were performed in blood and urine as a means to establish chronic cocaine use. We have applied serial histological sections, techniques of morphometry, and image analysis to quantify the density and affectation of connective/adipose tissue of the conduction system and intramyocardial vessels. The conduction system after chronic cocaine use showed potentially lethal changes with an increase in connective/adipose tissue at the level of the intranodal or perinodal tissue of the sinus node in 35% (7 hearts) and the atrioventricular node in 75% (15 hearts), with the most affected structure being the left bundle branch and the AV nodal artery (100%, 20 hearts). In conclusion, the histopathologic changes in nodes, the perinodal area, and small vessels may be a morphological substrate that offers an explanation about the mechanism of arrhythmias and sudden death in this population.
New Insights and Experimental Investigation of High-Temperature Gel Reinforced by Nano-SiO2
Authors: Guo Hongbin , Ge Jijiang , Li Longjie , Zhang Guoliang , Li Ziwei , Wang Wenhui , Liu Mingjia
Published: June 2022

The properties of a reinforced gel with partially hydrolyzed polyacrylamide (HPAM) as the main agent, water-soluble phenolic resin (WSPR) as the crosslinker, and nano-SiO2 as the stabilizer were evaluated in terms of gelation time, gel strength and thermal stability under the conditions of 110 °C and 12.124 g/L salinity in water. The results showed that the gelation time of the gel with high strength was adjustable from 3 to 23 h, remaining stable for more than 180 days under stratigraphic conditions, although with a certain degree of early dehydration in the gel. Cryo-scanning electron microscopy (cryo-SEM) and dynamic light scattering (DLS) analysis revealed that nano-SiO2 improves the dispersion of the polymer in water, resulting in a more homogeneous structure of the formed gel and thus improving the strength of the gels. In addition, rheological tests and cryo-SEM showed that the interaction between nano-SiO2 and the polymer could inhibit the degradation of polymer to a certain extent and improve the thermal stability of the gel. However, the oxidative degradation of the gel is still the main cause of early dehydration of water-soluble phenolic resin gel, and the addition of a small amount of hydroquinone to the gelants can significantly improve the antioxidative degradation properties of phenolic resin gel.
Facile Fabrication of Transparent and Opaque Albumin Methacryloyl Gels with Highly Improved Mechanical Properties and Controlled Pore Structures
Authors: Xu Mengdie , Mehwish Nabila , Lee Bae Hoon
Published: June 2022

For porous protein scaffolds to be employed in tissue-engineered structures, the development of cost-effective, macroporous, and mechanically improved protein-based hydrogels, without compromising the original properties of native protein, is crucial. Here, we introduced a facile method of albumin methacryloyl transparent hydrogels and opaque cryogels with adjustable porosity and improved mechanical characteristics via controlling polymerization temperatures (room temperature and −80 °C). The structural, morphological, mechanical, and physical characteristics of both porous albumin methacryloyl biomaterials were investigated using FTIR, CD, SEM, XRD, compression tests, TGA, and swelling behavior. The biodegradation and biocompatibility of the various gels were also carefully examined. Albumin methacryloyl opaque cryogels outperformed their counterpart transparent hydrogels in terms of mechanical characteristics and interconnecting macropores. Both materials demonstrated high mineralization potential as well as good cell compatibility. The solvation and phase separation owing to ice crystal formation during polymerization are attributed to the transparency of hydrogels and opacity of cryogels, respectively, suggesting that two fully protein-based hydrogels could be used as visible detectors/sensors in medical devices or bone regeneration scaffolds in the future.
How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia
Authors: Kasap Merve , Dwyer Donard S.
Published: June 2022

Schizophrenia is a highly heritable polygenic psychiatric disorder. Characterization of its genetic architecture may lead to a better understanding of the overall burden of risk variants and how they determine susceptibility to disease. A major goal of this project is to develop a modeling approach to compare and quantify the relative effects of single nucleotide polymorphisms (SNPs), copy number variants (CNVs) and other factors. We derived a mathematical model for the various genetic contributions based on the probability of expressing a combination of risk variants at a frequency that matched disease prevalence. The model included estimated risk variant allele outputs (VAOs) adjusted for population allele frequency. We hypothesized that schizophrenia risk genes would be more interactive than random genes and we confirmed this relationship. Gene–gene interactions may cause network ripple effects that spread and amplify small individual effects of risk variants. The modeling revealed that the number of risk alleles required to achieve the threshold for susceptibility will be determined by the average functional locus output (FLO) associated with a risk allele, the risk allele frequency (RAF), the number of protective variants present and the extent of gene interactions within and between risk loci. The model can account for the quantitative impact of protective variants as well as CNVs on disease susceptibility. The fact that non-affected individuals must carry a non-trivial burden of risk alleles suggests that genetic susceptibility will inevitably reach the threshold for schizophrenia at a recurring frequency in the population.
Analysis of Unmanned Aerial System (UAS) Sensor Data for Natural Resource Applications: A Review
Authors: Fraser Benjamin T. , Bunyon Christine L. , Reny Sarah , Lopez Isabelle Sophia , Congalton Russell G.
Published: June 2022

Unmanned Aerial Systems (UAS, UAV, or drones) have become an effective tool for applications in natural resources since the start of the 21st century. With their associated hardware and software technologies, UAS sensor data have provided high resolution and high accuracy results in a range of disciplines. Despite these achievements, only minimal progress has been made in (1) establishing standard operating practices and (2) communicating both the limitations and necessary next steps for future research. In this review of literature published between 2016 and 2022, UAS applications in forestry, freshwater ecosystems, grasslands and shrublands, and agriculture were synthesized to discuss the status and trends in UAS sensor data collection and processing. Two distinct conclusions were summarized from the over 120 UAS applications reviewed for this research. First, while each discipline exhibited similarities among their data collection and processing methods, best practices were not referenced in most instances. Second, there is still a considerable variability in the UAS sensor data methods described in UAS applications in natural resources, with fewer than half of the publications including an incomplete level of detail to replicate the study. If UAS are to increasingly provide data for important or complex challenges, they must be effectively utilized.
Climatic and Cultural Transitions in Lambayeque, Peru, 600 to 1540 AD: Medieval Warm Period to the Spanish Conquest
Authors: Sandweiss Daniel H. , Maasch Kirk A.
Published: June 2022

The Lambayeque Valley on the north coast of Peru offers a cautionary case study on the relation between climatic and cultural change. Three archaeological site complexes dating from late in the first millennium AD to the middle of the second millennium AD rose and were abandoned in sequence. Each abandonment was associated with a conflagration on the main pyramidal mound(s). In this region, El Niño is the most significant climatic disruption now and for millennia past. By tracking proxy records for El Niño intensity, we found that only the first episode of abandonment and burning was associated with a strong peak in El Niño intensity, while the final episode was the outcome of the Spanish Conquest of the Andes, a distinctly non-climatic driver. These records suggest that equifinality is operative and urge caution in over-interpreting climate as culture-changing catastrophe.
Improved Planktonic, Benthic Foraminiferal and Nannofossil Biostratigraphy Aids the Interpretation of the Evolution at Hole U1468A: IODP Expedition 359, the Maldives
Authors: Spezzaferri Silvia , Young Jeremy , Stainbank Stephanie , Coletti Giovanni , Kroon Dick
Published: June 2022

Extended shallow carbonate platform, pelagic, and drift deposits were drilled during International Ocean Discovery Program (IODP) Expedition 359 in the Inner Sea of the Maldives. These sediments yield rich and well-diversified benthic, planktonic foraminiferal and nannofossil assemblages spanning from the early Oligocene to the Recent. We present here the shore-based revised integrated biostratigraphy of these microfossil groups at IODP Hole 359-U1468A together with the paleobathymetric reconstruction. Our data suggests the presence of a late Oligocene carbonate platform, marked by the shallowest water depths of the entire sequence of around 80 m. This carbonate platform sequence occurred from around 29 Ma, the extrapolated minimum age estimate, at least up to 27.5 Ma and possibly up to 25.4 Ma. Up the sequence, similar carbonate production conditions occurred until 22.5 Ma across the Oligocene–Miocene transition, equated at 23.04 Ma, with increased water depths >120 m. Notably, in the time interval approximately from 24 to 21.5 Ma, orbitally induced sapropel layers indicate a change of open to restricted circulation. However, at around 22.5 Ma, pelagic deposition at a distal slope occurred with sedimentation rates of 3 cm/years. This initially occurred in water depths of >350 m but gradually reached deposition in water depths of >500 m, which persisted from 21.12 Ma until approximately the extrapolated age of 12.8 Ma. Sedimentation rates gradually increased to 10.5 cm/1000 years at around 450 m below sea floor, marking the initiation of the drift sequence as identified in seismic lines with an age estimate of 12.8 Ma. The initiation of the drift sequence is also marked by a drastic decrease in the preservation of benthic and planktonic foraminifera from good to very poor at around 12.8 Ma. The drift sequence essentially continued to the present day but was interrupted by two events: the deposition of distinct shallow water benthic shoals and a large hiatus. From 12.8 Ma, a shallowing upward bathymetry is suggested by the occurrence of shallow benthic foraminiferal assemblages that close to around 11.93 Ma reached a maximum water depth of 80 m. This shoal then prograded into the basin and persisted at least until 9.89 Ma. Basin conditions with water depths exceeding 500 m were re-established in the upper part of the sedimentary succession after a hiatus spanning approximately from 9.83 Ma to 2.39 Ma, implying that renewed open ocean conditions occurred in the Pliocene–Pleistocene part of the sedimentary record.
Petrophysical Characterization of Non-Magnetic Granites; Density and Magnetic Susceptibility Relationships
Authors: Pueyo Emilio L. , Román-Berdiel Teresa , Calvín Pablo , Bouchez Jean Luc , Beamud Elisabet , Ayala Conxi , Loi Francesca , Soto Ruth , Clariana Pilar , Margalef Aina , Bach Nuria , Schamuells Nia , Rubio Félix M. , Gimeno Ana , de Arévalo Elena Fernández , Rey-Moral Carmen , García Arturo , Martí Joan , Casas Antonio M. , García-Lobón José Luis
Published: June 2022

In this work we establish reliable correlations between density and magnetic susceptibility in three paramagnetic granites from the Pyrenees. In total, 128 sites (310 density measurements and >2600 susceptibility ones) were studied in the Mont Louis-Andorra, Maladeta and Marimanha granitic plutons covering the main range of variability of magnetic susceptibility. Regressions were calculated for every granitic body and an integrated linear function was obtained for the entire dataset: ρ (kg/m3) = 2566 (kg/m3) + 0.541κ (10−6 S.I.) (R:0.97). This relationship is only valid in the paramagnetic domain, where iron is mostly fractioned in iron-bearing phyllosilicates and the occurrence of magnetite is negligible (or at least its contribution to the bulk susceptibility). This relationship, likely different in other bodies, allows for transforming magnetic susceptibility data into density data, helping to constrain gravity modelling when density data from rock samples are scarce. Given the large amount of AMS studies worldwide, together with the quickness and cost-effectiveness of susceptibility measurements with portable devices, this methodology allows for densifying and homogenizing the petrophysical data when modelling granite rock volumes based on both magnetic and gravimetric signals.
The Current Contexts of Newly Graduated Nurses’ Competence: A Content Analysis
Authors: Hyun Areum , Tower Marion , Turner Catherine
Published: June 2022

Producing and sustaining a competent nursing workforce is imperative to protect the public. Identifying current issues and trends in nursing competence can strengthen insights and provide direction for the future nursing workforce. A summative content analysis was performed; PubMed, CINAHL, and Scopus were searched for content from the last ten years. A total of 3225 titles and abstracts regarding nursing competence were identified and analysed using the big-data analysis software Leximancer. Five themes were discovered from the analysis: (1) standardisation of nursing competencies with emerging competencies, (2) assessment competency levels, (3) graduates’ expectations and achievement, (4) safe and quality practice with teamwork, and (5) competency curriculum development. This found standardised nursing competencies, which suggests prioritising which core competencies should be focused on during education to produce competent generalist professional nurses, and employers could help nursing graduates improve their competence in specialised areas. This review also suggests that further education strategies should be developed to better prepare graduates for culturally safe practice to meet the needs of diverse minority populations and for informatics competency during the COVID-19 pandemic. Competence assessment methods must be extensively investigated to measure nursing competencies both longitudinally and cross-sectionally.
Oral Care Awareness and Factors Related to the Burden of Nurses at a Community Hospital in Japan
Authors: Koike Takashi , Ohta Ryuichi , Matsuda Yuhei , Sano Chiaki , Kanno Takahiro
Published: June 2022

Objective: This cross-sectional study investigated the oral care knowledge, awareness, and challenges of 159 nurses and identified the factors related to the burden of oral care in Unnan City Hospital, Japan. Materials and Methods: This study included outpatient, ward, and operating room nurses who answered a questionnaire comprising 19 questions regarding awareness, actual implementation status of oral care provided, burden and learning experiences of oral care, and participants’ characteristics. A univariate regression model was used to assess whether catheterization was associated with the independent variables. Results: The number and rate of valid questionnaires were 134 and 87.6%, respectively. The mean years of clinical experience were 18.71 ± 12.02 years; 95.5% of the nurses were women. There were significant differences in the Oral Health-related Caregiver Burden Index among “interest in oral care” (p = 0.006), “priority of oral care” (p = 0.005), and “burden of oral care”. Conclusions: This study shows that nurses who are highly interested in oral care, prioritize oral care, and do not perceive oral care as a burden. Educational interventions, such as training sessions and direct guidance to solve challenges, are needed and can lead to improvements in the quality of life and advancement of health.
Sustainable Upcycling of Mushroom Farm Wastewater through Cultivation of Two Water Ferns (Azolla spp.) in Stagnant and Flowing Tank Reactors
Authors: Kumar Pankaj , Eid Ebrahem M. , Taher Mostafa A. , El-Morsy Mohamed H. E. , Osman Hanan E. M. , Al-Bakre Dhafer A. , Adelodun Bashir , Abou Fayssal Sami , Andabaka Željko , Goala Madhumita , Singh Jogendra , Kumari Sonika , Arya Ashish Kumar , Choi Kyung Sook , Kumar Vinod , Širić Ivan
Published: June 2022

Nowadays, the increase in the wastewater generated from the mushroom cultivation sector has become a serious environmental pollution concern. Therefore, the present study aimed to assess the efficiency of two water ferns (Azolla pinnata and A. filiculoides) in phytoremediation of mushroom farm wastewater (MFW) under stagnant and flowing tank reactor systems. For this, the laboratory scale experiments were conducted using five treatments, i.e., control (absolute borewell water), S50 (15 L borewell water + 15 L MFW: stagnant mode), S100 (30 L MFW: stagnant mode), F50 (15 L borewell water + 15 L MFW: flowing mode), F100 (30 L MFW: flowing mode), separately for both Azolla spp. After 15 days, A. pinnata and A. filiculoides significantly (p < 0.05) reduced the physicochemical parameters of MFW such as pH (18.87 and 18.56%), electrical conductivity (EC: 80.28 and 78.83%), total dissolved solids (TDS: 87.12 and 86.63%), biochemical oxygen demand (BOD: 90.63 and 89.90%), chemical oxygen demand (COD: 86.14 and 85.54%), and total Kjeldahl’s nitrogen (TKN: 84.22 and 82.44%), respectively, in F100 treatment. Similarly, the highest growth and biochemical parameters of Azolla spp. were also observed while using absolute MFW treatment in a flowing tank reactor system. Moreover, out of the two tested growth kinetic models, the logistic model showed better fitness to the experimental data and prediction of critical growth parameters compared to the modified Gompertz model. The findings of this study are novel and suggest sustainable upcycling of MFW using plant-based treatment techniques with the production of high-quality Azolla spp. biomass.
Predicting Urban Flooding Due to Extreme Precipitation Using a Long Short-Term Memory Neural Network
Authors: Kilsdonk Raphaël A. H. , Bomers Anouk , Wijnberg Kathelijne M.
Published: June 2022

Extreme precipitation events can lead to the exceedance of the sewer capacity in urban areas. To mitigate the effects of urban flooding, a model is required that is capable of predicting flood timing and volumes based on precipitation forecasts while computational times are significantly low. In this study, a long short-term memory (LSTM) neural network is set up to predict flood time series at 230 manhole locations present in the sewer system. For the first time, an LSTM is applied to such a large sewer system while a wide variety of synthetic precipitation events in terms of precipitation intensities and patterns are also captured in the training procedure. Even though the LSTM was trained using synthetic precipitation events, it was found that the LSTM also predicts the flood timing and flood volumes of the large number of manholes accurately for historic precipitation events. The LSTM was able to reduce forecasting times to the order of milliseconds, showing the applicability of using the trained LSTM as an early flood-warning system in urban areas.
Down the Drain: A Systematic Review of Molecular Biology Evidence Linking Sinks with Bacterial Healthcare-Associated Infections in Intensive Care Units
Authors: Choquet Morgane , Mullié Catherine
Published: June 2022

This systematic review aimed to sum up the evidence gathered by molecular biology methods on the transmission of bacterial clones from sinks/sink drains environmental sources to intensive care unit (ICU) patients. Forty-five reports meeting inclusion/exclusion criteria were identified. Most were retrospective cohort studies on Gram negative multidrug resistant bacteria, with P. aeruginosa and S. marcescens being the most frequent species (26.7% and 17.8% of the studies, respectively). The reports using pulse field gel electrophoresis were the most numerous (44.4%) and found a common clone between clinical and sink/sink drains isolates in 80% of the cases. Over the last 5 years, the use of whole genome sequencing became more frequent and linked sink/sink drains isolates to clinical ones in 50% of the cases. Precise positivity timelines mostly pointed towards a patient-to-sink/sink drain transmission while only 8 reports provided back up for the sink/sink drain-to-patient. To better appraise the role of sinks/sink drains as a reservoir for nosocomial acquisition of bacteria in ICU, future reports should strive to give a precise timeline for the retrieval of isolates as well as the cut-off criteria used to assign isolates to a given clone (information lacking in 66.7% and 42.2% of the studies, respectively).
A Qualitative Analysis of the Mental Health Training and Educational Needs of Firefighters, Paramedics, and Public Safety Communicators in Canada
Authors: Lentz Liana , Smith-MacDonald Lorraine , Malloy David C. , Anderson Gregory S. , Beshai Shadi , Ricciardelli Rosemary , Bremault-Phillips Suzette , Carleton R. Nicholas
Published: June 2022

Background—Public safety personnel (PSP) are at heightened risk of developing mental health challenges due to exposures to diverse stressors including potentially psychologically traumatic experiences. An increased focus on protecting PSP mental health has prompted demand for interventions designed to enhance resilience. While hundreds of available interventions are aimed to improve resilience and protect PSPs’ mental health, research evidence regarding intervention effectiveness remains sparse. Methods—Focus groups with PSP elicited a discussion of psychoeducational program content, preferred modes of program delivery, when such training should occur, and to whom it ought to be targeted. Results—The results of thematic analyses suggest that PSP participants feel that contemporary approaches to improving mental health and resilience are lacking. While welcomed, the provision of sporadic one-off mental health and resilience programs by organizations was seen as insufficient, and the available organizational mental health supports were perceived as being questionable. The available programs also left participants feeling insufficiently prepared to deal with personal mental health problems and in discussing mental health concerns with co-workers. Conclusions—Participants reported needing more engaging methods for delivering information, career-long mental health knowledge acquisition, and a systems approach to improve the workplace culture, particularly regarding mental health.