bluuebunny/crossref_metadata_2025 huggingface dataset:
MACHINE LEARNING TO CREATE DECISION TREE MODEL TO PREDICT OUTCOME OF ENTERPRENEURSHIP PSYCHOLOGICAL READINESS (EPR)
Authors: Syafitri Nesi , Farradinna Syarifah , Jayanti Wella , Arta Yudhi
Published: August 2023

This study aims to create a decision tree model using machine learning to predict psychological readiness for entrepreneurship in college graduates. This research was conducted through several stages of research. In the early stages, a survey was conducted on 700 students from several universities in Riau aged between 17-25 years. The survey was conducted using the Entrepreneur Psychology Readiness (EPR) instrument. Furthermore, the survey data was validated and obtained 604 valid data to be used in forming machine learning models The urgency of this research is to find a number of decision rules from the best decision tree model to be used in building AI-based counseling applications in measuring entrepreneurial psychology readiness for college graduates. In this research, the decision tree model that is formed is divided into 2 models, namely: decision tree with pruning model and decision tree with unpruning. The pruning decision tree model produces 180 decision rules, while the unpruning model produces 121 decision rules. Good accuracy results are obtained in the pruned decision tree, which is above 99% in the use training set mode, and 82.87% in the percentage split mode. Meanwhile, the accuracy results on the unpruned decision tree are 90.18% with the use training set mode test, and 80.38% in the percentage split mode. The decision tree model with pruning technique has better performance than the unpruning decision tree model.
A NEW MODEL FOR HYDROPONIC LETTUCE NUTRITION ADAPTIVE CONTROL SYSTEM BASED ON FUZZY LOGIC SUGENO METHOD USING ESP32
Authors: Kaswar Andi Baso , Mahande Ridwan Daud , Malago Jasruddin Daud
Published: August 2023

In the last few years, the terms Smart Agriculture, Smart Farming, Urban Farming, or Precision Farming have been increasingly recognized and growing rapidly. Hydroponics is one part that is currently a trend, both in industrial or household scale businesses and hobbies. One of the most important things to consider in maintaining the quality of hydroponic plant growth is the concentration of nutrients in the water. A series of studies have been conducted to improve the quality of hydroponic plants. However, the developments that have been carried out have not focused on optimal nutritional control. The previous hydroponic plant nutrition control system still used conventional methods, namely the use of a rule base with firm values ​​, and did not consider the quantity and quality of water. Therefore, this study proposes a new model for an adaptive control system for hydroponic lettuce nutrition based on the Fuzzy Logic Sugeno method using ESP32. The fuzzy logic Sugeno method is used to create a new model of the inference system for determining the amount of nutrient dosage based on supporting data obtained from sensors installed on hydroponic growing media. Compared with the conventional method, the resulting test results show that the proposed method can adapt the amount of added nutrients, provide optimal nutrient addition output, and prevent excess nutrient additions that can potentially accumulate toxic ions in water that degrade water quality.
HYBRIDIZATION OF THE NAIVE BAYES CLASSIFICATION METHOD IN THE FRESHWATER FISH SEED SELLER CLASSIFICATION MODEL
Authors: Ariansyah M Hafidz , Fitri Esmi Nur , Winarno Sri , Rohmani Asih , Budiman Fikri , Zeniarja Junta , Sugiarto Edi
Published: August 2023

Freshwater fish seed sellers play several roles in the supply chain process in the freshwater fish farming business. The role of the seller of freshwater fish seeds in this process is to distribute fish seeds which are one of the upstream sources in the supply chain process. Freshwater fish cultivators must select competent freshwater fish seed sellers so the supply chain process can run well. A large number of freshwater fish seed sellers in the market remind freshwater fish cultivators to choose the quality of the freshwater fish seed seller in terms of seed quality, low prices, shipping that can reach many areas, ergonomic packaging, and others. This study proposes Hybrid Naïve Bayes Classifiers (HNBCs) as a machine learning method for classification. This study aimed to compare the seed seller classification method in which the appropriate pattern of seed seller was identified by hybridization of Naïve Bayes Classifiers (NBCs), and then the researchers conducted performance appraisal and evaluation. The results are beneficial for freshwater fish cultivators and researchers which will enable them to formulate their plans according to the predicted results. The proposed method has produced significant results by achieving a training data accuracy of 82.61% and the testing data accuracy of 73.91%.
BLUEPRINT FOR RECORDING DATA ON RED ONION FARMING ACTIVITIES USING THE BPR METHOD
Authors: Noor Saputra Muhammad Riza , Alzami Farrikh , Biyantama Kukuh , Abdillah Muhammad Ridho , Steven Alvin , Umam Chaerul , Nurhindarto Aris , Wahyudi Firman
Published: August 2023

To advance agriculture in Indonesia, farmers must be able to calculate the need for fertilizer, optimal use of pesticides, the amount of irrigation water required, the type of seed and the suitable land area in order to get maximum and sustainable agricultural yields. Besides that, farmers must also know the efforts in preventing and handling diseases. Therefore, researchers developed a prototype for recording data on agricultural activities both carried out by farmers and recording the condition of agricultural land by IOT. The Business Process Reengineering method is used to obtain an AS-IS system analysis so that a blueprint model is obtained that is suitable for recording agricultural activities. So that red onion farmers can manage customer relationships while performing their agricultural activities using this web-based information system application prototype. The results of the recording carried out by farmers and IOT using the Laravel web-based application development and using PostgreSQL version 14 can be used to provide input and notifications to farmers regarding actions that need to be taken.
ANALYZING SURICATA ALERT DETECTION PERFORMANCE ISSUES BASED ON ACTIVE INDICATOR OF COMPROMISE RULES
Authors: Raharjo Didit Hari Kuncoro , Muhammad Salman
Published: August 2023

Many studies have been related to the Intrusion Detection System (IDS) performance analysis. Still, most focus on inspection performance on high-capacity networks with packet drop percentage as a performance parameter. Few studies are related to performance analysis in the form of detection accuracy based on the number of rules activated. This research will analyze the performance of IDS Suricata based on the number of active rules in the form of Indicator of Compromise (IoC), including IPRep, HTTP, DNS, MD5, and JA3. The analysis method focuses on the detection accuracy of varying the number of active rules up to 1 million, expressed in 5 scenarios. In scenarios 1 to 4, where IoC rules are tested separately, the reduction in detection accuracy performance starts to occur when the number of active rules is at 100,000 and continues to decrease when the number reaches 1 million. However, in scenario 5, where the IoC rules are tested together, the percentage of rules detection accuracy decreases when the number of active rules from each IoC is less than 10,000. The percentage decrease in detection accuracy performance in scenario five can occur with an average reduction of 19.64%. Even further in scenario 5, when the total number of rules reaches 1,000,000 or 200,000 from each IoC, IDS Suricata fails to detect all rules (detection percentage is 0%). This research show that the higher number of rules activated, the decrease in the Suricata IDS performance in terms of detection accuracy.
A MACHINE LEARNING APPROACH TO EYE BLINK DETECTION IN LOW-LIGHT VIDEOS
Authors: Rasyid Muhammad Furqan , Rizal Muhammad , Musu Wilem , Hadis Muhammad Sabirin
Published: August 2023

Inadequate lighting conditions can harm the accuracy of blink detection systems, which play a crucial role in fatigue detection technology, transportation and security applications. While some video capture devices are now equipped with flashlight technology to enhance lighting, users occasionally need to remember to activate this feature, resulting in slightly darker videos. Consequently, there is a pressing need to improve the performance of blink detection systems to detect eye accurately blinks in low light videos. This research proposes developing a machine learning-based blink detection system to see flashes in low-light videos. The Confusion matrix was conducted to evaluate the effectiveness of the proposed blink detection system. These tests involved 31 videos ranging from 5 to 10 seconds in duration. Involving male and female test subjects aged between 20 and 22. The accuracy of the proposed blink detection system was measured using the confusion matrix method. The results indicate that by leveraging a machine learning approach, the blink detection system achieved a remarkable accuracy of 100% in detecting blinks within low-light videos. However, this research necessitates further development to account for more complex and diverse real-life situations. Future studies could focus on developing more sophisticated algorithms and expanding the test subjects to improve the performance of the blink detection system in low light conditions. Such advancements would contribute to the practical application of the system in a broader range of scenarios, ultimately enhancing its effectiveness in fatigue detection technology.
FUEL INCREASE SENTIMENT ANALYSIS USING SUPPORT VECTOR MACHINE WITH PARTICLE SWARM OPTIMIZATION AND GENETIC ALGORITHM AS FEATURE SELECTION
Authors: Imanuela Mustamu Laura , Sibaroni Yuliant
Published: August 2023

BBM, or fuel oil, is one of the essential needs of the Indonesian people. The government's policy regarding the increase in fuel prices raises many opinions from the public. Twitter is one of the social media that Indonesian people often use to express opinions on a topic. In this study, sentiment analysis was carried out on public opinion regarding the fuel price increase policy from Twitter social media. This research is expected to help determine public opinion regarding the fuel price increase policy with positive, neutral and negative sentiments. The sentiment analysis method used is the Support Vector Machine (SVM) classification algorithm. The results of the accuracy of SVM were compared with accuracy by adding a feature selection process. The Particle Swarm Optimization (PSO) and Genetic Algorithm (GA) algorithms are used for the feature selection method. After several experiments using the three methods, the SVM method with the Radial Basis Function (RBF) kernel produced the best accuracy of 71.2%. The combination of the SVM method with the RBF and PSO kernels obtained an accuracy of 68.84%, and the combination of the RBF and GA kernel SVM methods obtained an accuracy of 69.52%.
ANDROID MOBILE-BASED ENGLISH LEARNING GAME EDUCATION FOR CHILDREN IN INDONESIA
Authors: Putri Devi Afriyantari Puspa , Priyawati Diah , Arrizka Nur Khaulah , Khasanah Fadilla Setia , Litaswari Inesti
Published: August 2023

The increasing use of english languange and its importance as a global languange make english languange become important to learn and understand by many people. However, there are some difficulties in learning English, especially for early childhood in Indonesia, due to various factors, including: lack of vocabulary, and teaching materials and books that are less innovative. Therefore, this study aims to build an edugame that contains animal and fruit vocabulary for early childhood in Indonesia based on the CCI guidelines to make applications that are quite innovative. The ADDIE method was chosen as the research method used which consists of: pre-production, production, and post-production. The edugame application in this reseacrh contains of two main menus, are: learning menu that contain fruits and animal vocabularies alongside with sound of their spelling, and play game menu, that challenge children to guess the correct answer of every vocabulary. According to the result of pretest and posttet test that conducted on 40 children with parental assistance showed the increasing of scores in answering list of questions. Besides that, the SUS testing carried out in this research got an average point about 84.81 which means that the applicatian has a good function and can be accepted by users.
IMPLEMENTATION OF THE RANDOM FOREST ALGORITHM IN CLASSIFYING THE ACCURACY OF GRADUATION TIME FOR COMPUTER ENGINEERING STUDENTS AT DIAN NUSWANTORO UNIVERSITY
Authors: Rachmawati Devi Ayu , Ibadurrahman Nitho Alif , Zeniarja Junta , Hendriyanto Novi
Published: August 2023

To ensure the existence of a university remains intact, one way that can be done is by optimizing the performance of the students so that they can graduate on time. A high percentage of on-time graduation will result in a good assessment of the accreditation of the department in the university. However, there are many factors that affect the graduation rate, such as the student's academic performance, extracurricular activities, and other factors. The data of graduation of students in the Computer Science program at the Faculty of Computer Science, Dian Nuswantoro University, for the academic years 2008-2017 is the object of this study. The objective of this research is to create the best classification model using the Random Forest algorithm to predict the accuracy of the graduation time of students, which will be useful for policy making in the future. The results of the classification using this algorithm received an accuracy of 93% for the training data and 91% for the test data.
ACCREDITATION PREDICTION OF EARLY CHILDHOOD EDUCATION INSTITUTIONS USING MACHINE LEARNING TECHNIQUES
Authors: Noripansyah Noripansyah , Kadir Abdul , Kusumaningsih Dewi , Haderiansyah Haderiansyah
Published: August 2023

Accreditation is an acknowledgement of an educational institution regarding the feasibility of carrying out the educational process. Making predictions can save time for early childhood education institutions in compiling accreditation forms that will be submitted. Prediction in determining accreditation becomes an important lesson for an institution in self-assessing the quality of its services. Choosing which method to use in the accreditation prediction process becomes a serious problem, so the prediction results can be the closest or most accurate. Machine Learning is an application that is part of Artificial Intelligence which is widely used in prediction research. In this experiment, three algorithms in machine learning are tested, namely SVM, KNN and ANN. This study uses data from the accreditation results of early childhood education institutions in South Kalimantan; the sample data is 75%, and the remaining data is 25%. The results of the KNN algorithm with Euclidean distance and the number of neighbours 5 have the best performance in predicting the value of the accreditation predicate compared to other methods. The results of calculations using the KNN method produce Area Under Curve values of 1,000, CA 1,000, F1 1,000, precision 1,000 and Recall 1,000.
Cuidado infantil e análise de redes sociais
Authors: Kovalczuk de Oliveira Garcia Amanda
Published: August 2023

Considerando o cuidado de crianças, especialmente em contextos de pobreza, é uma atividade que acontece sobretudo pela mobilização de pessoas que compõem a rede pessoal das cuidadoras, o artigo propõe o uso de uma metodologia relacional, a análise de redes sociais (ARS), para a compreensão das estratégias desenvolvidas pelas famílias para o cuidado infantil cotidiano. Concebe-se o cuidado como uma organização social e, enfatizando o contexto brasileiro de déficit de políticas públicas para este fim, apresenta-se uma revisão bibliográfica sobre o cuidado realizado em ajudas mútuas, coletivos de bairro e circulação de crianças. Após, apresenta-se a análise de redes sociais como metodologia adequada para captar a dimensão relacional do cuidado infantil, argumentando pelo seu uso para a compreensão de como as redes sociais das cuidadoras pode influenciar as estratégias de cuidado desenvolvidas pelas famílias. Sugere-se, assim, que uma perspectiva relacional permitiria a compreensão de padrões de sociabilidade que são ativados para gerar soluções para problemas de cuidado cotidianos nas vidas das cuidadoras, e que o uso da análise de redes pode iluminar a uma importante intersecção entre organização social do cuidado e relações sociais.
Edifício Taperinha no imaginário de Santa Maria, RS
Authors: Scortegagna Socal Ana Júlia
Published: August 2023

O Edifício Taperinha, localizado no centro da cidade de Santa Maria, é uma das edificações mais representativas da arquitetura moderna local. O objetivo geral deste estudo foi compreender a importância do Edifício Taperinha e a sua presença no imaginário associado à Santa Maria. Como objetivos específicos, se propôs a: investigar a participação do edifício no contexto histórico da cidade; compreender o projeto e as particularidades do Taperinha; e identificar de que forma ele é reconhecido e representado em cartões-postais. A metodologia baseia-se em duas etapas: 1) pesquisa bibliográfica, com referências sobre cartões-postais e sobre a cidade de Santa Maria e o Edifício Taperinha; 2) pesquisa documental, na qual buscou-se junto ao Arquivo Histórico Municipal e em fontes online cartões-postais que retratassem a cidade de Santa Maria. Os resultados encontrados mostram que a composição volumétrica e altura do Taperinha fizeram com que este se destacasse no skyline urbano e se fixasse no imaginário popular. Os seis cartões-postais mostram que o prédio compunha, junto com outros elementos urbanos, a imagem que se tinha da cidade à época.
Saudades do Brasil
Authors: Adorno Sergio
Published: August 2023

O texto que se segue foi escrito, sob a forma de homenagem e saudação, por ocasião da concessão do título de Professor Emérito à Professora Doutora Marlyse Meyer da Faculdade de Filosofia, Letras e Ciências Humanas da Universidade de São Paulo, no dia 16 de abril de 2009. Imaginação e realidade; realidade e imaginário. Eis os territórios pelos quais transitaram a pesquisa e a obra de Marlyse Meyer. É tarefa difícil recensear seu percurso intelectual. Reconstruir perfis intelectuais demanda, a par de conhecimentos específicos, muitos dos quais nutridos em convivência pessoal com biografados, a descoberta de um fio condutor que permita alinhar cronologias e temporalidades históricas, sejam as de investigação, as de interesse por temas ou questões, ou ainda as de oportunidades de produção e edição de textos seguidas de suas publicações. Marlyse apresenta longas páginas estabelecendo conexões entre mudanças sociais e produção cultural. Mudanças operadas no mercado de jornais e livros, nos efeitos da industrialização e urbanização nos hábitos de consumo entre as classes sociais, na emergência de novas classes saídas do operariado fabril, nas conjunturas ora repressivas ora liberalizantes pelos quais passou a história política francesa parecem enredar a produção cultural. Fiel aos “objetos” a que se debruçou, sua extensa atividade de pesquisa se revela autêntica nos fragmentos, na dispersão, na descontinuidade, nos olhares através de labirintos e contracantos, na pluralidade das fontes originais de investigação a respeito das raízes de nossa cultura e de nossas tradições literárias.
¿Qué es vivir bajo el regimen de la bestia?
Authors: Viscardi Nilia
Published: August 2023

En la postura y en el relato, la narración histórica de la violencia que hace Butazzoni abre el camino para una interpretación crítica de la violencia sin abandonar la autocrítica a los movimientos políticos y revolucionarios de los años setenta. En la elección de los variados casos y situaciones, prevalece la denuncia de una violencia estructural, política, estatal, institucional y patriarcal que lucha por mostrar la humanidad de quienes se encontraron en esa desigual batalla política que se libró en el continente latinoamericano.Las violencias -nuevas y viejas- que encontramos en escenarios pos-dictatoriales tienen lugar en una democracia en que se banalizan día a día la crueldad y letalidad de diversas prácticas sufridas por poblaciones vulnerables. El ejercicio del sadismo y de la violencia de estado deja huella y la búsqueda por reconstruir una sociedad democrática y respetuosa de los derechos humanos reclama una sociología de las prácticas de violencia que escape al reduccionismo criminológico y postule preguntas políticas, filosóficas, antropológicas y humanas, presentes todas ellas en la obra de Butazzoni. De allí que su lectura toma valor para la interpretación crítica de un presente y de una actualidad, que se ahoga en una pornografía de la violencia divulgada sin más objeto que el de la criminalización y la despolitización del conflicto.
Towards Metric Monocular SLAM using Spoken Language and Object Detection
Authors: Martinez-Carranza Jose , Hernandez-Farias Delia , Rojas-Perez Leticia , Cabrera-Ponce Aldrich
Published: August 2023

We present initial results of a novel approach, merging spoken language and visual object detection to generate depth images in real-time monocular SLAM systems without depth cameras. Our method uses a matrix representation for language and objects, and a partitioning algorithm for association. Whisper processes spoken language, whilst YOLO handles object detection. ORB-SLAM handles camera pose estimation and scene mapping. Users can explore the scene, observe detected objects, and offer depth information via speech. Our system converts descriptions into depth images. Experiments in indoor settings reveal results comparable to RGB-D images, maintaining real-time performance.
POLPA DESCELULARIZADA COMO ARCABOUÇO BIOATIVO NA REGENERAÇÃO PULPAR PELO MÉTODO CELL HOMING: UMA INVESTIGAÇÃO EM ANIMAL
Authors: Carneiro Verydianna Frota , Santiago Sérgio Lima
Published: August 2023

A polpa dentária descelularizada é um arcabouço natural possível para a regeneração e oferece vantagens específicas sobre outros biomateriais. No entanto, as evidências que apoiam sua eficácia na regeneração pelo método cell homing ainda não estãobem estabelecidas. O presente projeto de pesquisa tem como objetivos: revisar a literatura científica sobre a modalidade regenerativa cell homing; e avaliar aspectos histológicos e imuno-histoquímicos do tecido neoformado na regeneração pulpar,pelo método cell homing, utilizando a polpa descelularizada, em modelo semiortotópico. Na revisão sistemática serão consultados oito bases, em busca de estudos primários, com diferentes combinações de descritores. Para avaliação dorisco de viés será utilizado o instrumento SYRCLE, seguido da análise descritiva, e caso seja possível, será realizada meta-análise com um nível de confiança de 95%. No estudo pré-clínico serão utilizados 36 raízes, divididas de acordo com tratamento:grupo PD, com inserção no interior do canal radicular da polpa descelularizada; grupo COL, com a utilização de esponja de colágeno, como arcabouço; e grupo SEM, no qual não será utilizado nenhum arcabouço. As amostras serão inseridas no dorso decamundongos, e após 4 semanas, os animais serão eutanasiados. Os tecidos formados serão analisados em relação a organização e crescimento e passarão por uma avaliação imuno-histoquímica. Após verificação da existência de normalidade,os dados passarão por análise estatística.
EFEITOS DA TERAPIA PROBIÓTICA COM KEFIR DE LEITE NO OSSO MANDIBULAR DE RATOS COM OSTEOPOROSE INDUZIDA POR GLICOCORTICOIDES (OIG)
Authors: Maia Thays Allane Cordeiro , Costa Ana Carolina de Figueiredo , Vasconcelos Raquel Felipe de , Dutra Paula Goes , Gondim Delane Viana
Published: August 2023

A OIG desequilibra a remodelação óssea, podendo afetar a mandíbula. Os bifosfonatos são o padrão-ouro para o seu tratamento, entretanto, seus efeitos adversos incentivam a busca por terapias adjuvantes, como o Kefir de leite (KL), que aumenta a absorção e incorporação de cálcio nos ossos. Com isso, avaliou-se o efeito do KL no osso mandibular de ratos com OIG. 30 ratos Wistar machos foram divididos nos grupos controle (C), OIG e OIG+KL. A OIG foi gerada pela injeção intramuscular de dexametasona (7 mg/kg, 1x/sem/5sem). A administração do KL (0,7ml/animal/dia) foi por gavagem oral por 16 semanas. Na semana 22 realizou-se a eutanásia e remoção das mandíbulas para análise histomorfométrica, biomecânica, espectroscopia Raman e dosagem de fosfatase alcalina óssea (FAO). O grupo OIG+KL apresentou redução do número de lacunas vazias e aumento do número de osteócitos e da área óssea interradicular quando comparado ao grupo OIG. O grupo OIG apresentou redução da razão matriz mineral/orgânica, a qual foi elevada no grupo OIG+KL. O grupo OIG+KL apresentou aumento da substituição de carbonato e redução da razão hidroxiprolina/prolina. Os grupos com OIG apresentaram redução da cristalinidade e carga de fratura, sem reversão pelo KL. Os níveis de FAO reduziram no grupo OIG e aumentaram no OIG+KL. Dessa forma, a OIG afeta a integridade, composição e biomecânica da mandíbula e o tratamento com KL melhora a organização e qualidade óssea, podendo ser adjuvante no tratamento da osteoporose.
Práticas pedagógicas e inclusão de estudantes com deficiência intelectual nos anos finais do ensino fundamental
Authors: Medeiros Ricardo Tavares de , caetano Andressa Mafezoni
Published: August 2023

O livro evidencia nosso compromisso para com o direito social à Educação como público e subjetivo. Reitera o pressuposto de que todos têm condições de aprender. Com isso, assume o professor como pesquisador de práticas pedagógicas inclusivas e os estudantes com deficiência intelectual como sujeitos histórico-culturais. Promove reflexões sobre a escolarização desses discentes nos anos finais do ensino fundamental, o que requer práticas pedagógicas inclusivas, investimentos na formação dos professores, acessibilidade aos conhecimentos, processos de mediação comprometidos com a aprendizagem na igualdade-diferença e redes de colaboração entre a classe comum e o atendimento educacional especializado. Convida os profissionais da educação a refletirem sobre como as práticas pedagógicas são significadas e que elementos atravessam os processos de aprendizagem e desenvolvimento na escola comum. Os autores
Isolation, Characterization and Docking Analysis of Lycopene from Solanum lycopersicum and Daucus carota
Authors: Gupta Poonam , Johri Sonia , Jha Namrata , Shrivastava Sadhana , Agrawal Anurag
Published: August 2023

Tomato (Solanum lycopersicum) is a berry type fruits and red carrot (Daucus carota) is a root vegetable which have essential micronutrient for the human diet. Carotenoids, polyphenols and vitamins present in tomato and red carrot act as antioxidants, anticarcinogens, and well known to promote human health and is considered as a vital functional food. Lycopene is a main carotenoid in tomatoes and red carrot, accountable for the red color of tomatoes and carrot. Lycopene can trap singlet oxygen and reduce mutagenesis. Lycopene reveals important role in a number of chronic diseases such as cancer. The present study was aimed to characterize, compare and evaluate the lycopene content in tomatoes and carrots and determine, red carrots can be an alternative source of lycopene because fresh tomatoes have a shorter shelf life than carrot. The molecular docking is presented between lycopene and Human homooxygenase enzyme-1 (HO-1) that potentiate it as a suitable antioxidant molecule.
Identification and quantification of Shatavarin IV in five different species of the genus Asparagus through a validated HPTLC method
Authors: Bhusan Champati Bibhuti , Mohan Padhiari Bhuban , Ray Asit , Sahoo Ambika , Jena Sudipta , Sahoo Tirthabrata , Chandra Panda Pratap , Nayak Sanghamitra
Published: August 2023

The steroidal saponin, Shatavarin IV is the major bioactive compound present in the root of Asparagus racemosus. Shatavarin IV contributes for a wide range of biological activities like antioxidant, antitussive, antidyspepsia, antiulcer and anticancer activity. The present investigation aimed to identify Shatavarin IV in five different species of the genus Asparagus. For the very first time, Shatavarin IV was identified in four species of Asparagus like Asparagus densiflorus, Asparagus setaceus, Asparagus plumosus and Asparagus sprengeri. The identification and quantification of Shatavarin IV was done by HPTLC analysis. The pre-coated silica gel 60 F254 plates were used as stationary phase for the development of chromatograms with ethyl acetate‒methanol‒water (7.5:1.5:1, v/v/v)) as mobile phase. The Shatavarin IV was detected at retardation factor (Rf) 0.55±0.05 and showed maximum absorption at 425nm. The method was validated for quantitative analysis and was found to be satisfactory. The six-point calibration curve of Shatavarin IV shows a standard deviation of 3.89 % with R2 value of 0.9968. The amount of Shatavarin IV were found to be 0.22%, 0.01%, 0.08%, 0.04% and 0.06% in A. racemosus, A. densiflorus, A. setaceus, A. plumosus and A. sprengeri respectively. The HPTLC Fingerprint developed in this research work could be useful for quality control and checking adulteration of all the five species of Asparagus. The presence of Shatavarin IV in other species of Asparagus would reduce the pressure on the Asparagus racemosus as theprimary source of drug thereby preserving its wild population.
Fabrication and Evaluation of Polymeric Nanoparticles of Acitretin for the Solubility Enhancement
Authors: G. Prajapati Bhupendra , Paliwal Himanshu , Patel Mayuree
Published: August 2023

The present study was an attempt to prepare nanoparticle of Acitretin which is used in Psoriasis. The preparation of nanoparticles was done by precipitation method employing several blends of polymers such as PVPK 30, PVPK 90, Poloxamer 407 and Poloxamer 188. The oral nanoparticles were characterized for various physicochemical parameters, such as particle size analysis, drug-excipient interactions, zeta potential, saturated solubility, XRD study, in-vitro drug release, FTIR spectroscopic studies displayed that there were not any interactions between drug and excipients. The nanoparticle batch F8 was found to be optimum batch based upon the outcomes obtained from the physicochemical characterization of nanoparticles. The mean particle size of nanoparticle batch F8 containing showed 96.01 % release at the end of 90 min and formulation displayed good nanoparticle strength.
The effect of Self-Care on Clinical Outcome of Outpatient Diabetes Mellitus Type 2 in Regional General Hospital West Nusa Tenggara Province
Authors: Leny Nopitasari Baiq , Adi Jaya Made Krisna
Published: August 2023

Type 2 Diabetes Mellitus is a disease characterized by elevated blood glucose levels and cannot be cured, so it needs self-care. Diabetes self-care was an important things in the management of type 2 DM, self-care is carried out by patients with DM in their lifetime. There are several factors that effect self-care including diet, physical activity, medicinal used, blood sugar control and foot care. This study aimed to determine the influence of self-care to blood sugar levels of type 2 diabetes mellitus in Regional General Hospital West Nusa Tenggara Province. This research used analytical observation method with 34 respondens using a questionnaire. The Summary Diabetes Self-Care Activity (SDSCA) and the data was analyzed using linear regression. The research showed that dietary factors have a significant effect on fasting blood glucose level (FBG) with a significance value p(0.012). In addition, there are positive correlation between the level of self-care in type 2 Diabetes Mellitus patient to HbA1C levels (r = 0.254, p = 0.023). The conclusion of this research was the level of self-care in type 2 Diabetes Mellitus patient had a positive effect on the patient’s clinic outcome including FBG, blood glucose 2 hour post prandial, random blood glucose, and HbA1c.
Effects of Rosuvastain on Bone Healing
Authors: H. Saeed Hiba , Al-Saffar Maha T. , S. Mahmood Abdulsattar
Published: August 2023

Statin has been used in other indication for their principle discovery due to their pleotropic effects. In the present study we would like to test the hypothesis of healing effects of rosuvastatin on induced bone lesion model in a rabbits. To do so, a bone injury rabbit model were used and the rabbit was administered rosuvastatin daily and sacrificed continuously for histopathology at day 7, day 14, and day 21. Results indicated that rosuvastatin induced beneficial healing process on the bone injury. Conclusion: bone healing could be a target for healing using rosuvastatin.
Synthesis and Antidepressant activity of some N-substituted-2-phenyl indole derivatives
Authors: Prasad Sahu Ram , Prakash Gupta Surya
Published: August 2023

In this investigation, few 1-ethyl acetate-2-phenylindole derivatives were synthesized and the antidepressant activity of these molecules was assessed in forced swim test and tail suspension test. The synthesis of the target molecules required three steps leading to the formation of phenyl indole using Fisher indole synthesis followed by the substitution of ethylacetate to the ring nitrogen of indole. The IR spectra showed stretching and bending vibrations at 1300-1100 cm-1(C-N), 1500-1700 cm-1 (C=C), 3000-3200 cm-1 (C-C) and 2600-3000 cm-1 (CH). Similarly vibrations due to C-O (1000-1100 cm-1), OH (3200-3500 cm-1) and Nitro (1400-1500 cm-1) were displayed. The standard drug fluoxetine and the test compounds 3d and 3e were found to significantly reduce the immobility of mice TST and enhance the swimming frequency.
Comparative Studies on Clinical Isolates of Hypervirulent and Classical Klebsiella pneumoniae
Authors: Ramadan Mohamed , El-mowafy Mohammed , Abdelmegeed Iman , Barwa Rasha
Published: August 2023

Hypervirulent Klebsiella pneumonia (hvKP), typically linked with the hypermucoviscous phenotype, has evolved as a clinically significant pathogen responsible for catastrophic disseminated infections including osteomyelitis, pyogenic liver abscesses (PLA), and endophthalmitis in an otherwise younger and healthier population. Methods: Mansoura University Hospitals, Egypt have utilised VITEK® 2 to identify clinical K. pneumoniae isolates. The Kirby Bauer's disc diffusion method was employed to asses sensitivity to antimicrobial. String test for detecting microvasculitis, Serotyping, and Bio-typing are among the phenotypic methods employed. Polymerase chain reaction (PCR) was performed to amplify capsular serotype-specific genes (K1 and K2) as well as virulence-associated genes (rmpA and magA). Results: Over two-years, 100 hypermucoviscous phenotype K. pneumoniae and 100 classical K. pneumoniae strains were isolated and screened by string test. Hypermucoviscosity Serotyping revealed that 76 isolates had K1-type capsules, 19 had K2-type capsules, and 5 were non-K1/K2 isolates. Among the positive hypermucoviscusisolates, the prevalence of rmpA gene was 79 %, and magA gene was 40 %. Although, the prevalence of these two genes in classical Klebsiella pneumoniae (cKP) isolates was very low 11% and 7%, respectively. Aside from that, the occurrence of K capsular genes in hvKP isolates were; K1 gene 66% and K2 gene 63%.However, the occurrence of these genes in cKP isolates were limited. Conclusion: In our geographical area, hypervirulent Klebsiella pneumoniae hvKP isolates were infrequent among K. pneumoniae isolates (El-Mansoura, Egypt). This study summarized and concentrated on the epidemiology, hypervirulence-associated variables, and antibiotic resistance mechanisms of hvKP strains. This was done to let the microbiologist or clinician know that the infecting strain could be hvKP, which is more dangerous than cKP. As a result, detecting these hypervirulent strains, which harbor resistance variants, should be a top goal priority.
A Comprehensive Review on the Antidiabetic Activity of Oxadiazole Derivatives
Authors: Bhat Nanditha , Kumar Abhishek , Kumar Pankaj , Pai Aravinda
Published: August 2023

Oxadiazoles, a class of five membered heterocyclic azoles, are considered to be a versatile scaffold and is found to be a core moiety of various pharmaceutically active agents.Oxadiazoles are known to inhibit alpha-amylase and alpha-glucosidase enzyme which is rational approach for selecting oxadiazole as antidiabetic agents in controlling postprandial hyperglycemia in type II diabetes mellitus. They are found to exist in 4 different regioisomeric forms namely 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole and 1,3,4-oxadiazole. Oxadiazoles are known to exhibit a wide range of biological activities and many mono and di-substituted oxadiazoles have been studied for their antihyperglycemic potential. Oxadiazoles have been found to act on various potential targets of the antidiabetic therapy. They are found to elicit hypoglycemic action by different mechanisms like inhibition of digestive enzymes, insulin sensitization, reduction of renal glucose reabsorption, etc. The results of various substituted oxadiazoles studied for their anti-diabetic activity has been reviewed in this article.
Effect of Biotin Treatment on the improvement of Lipid Profile and Foam Cells in Dyslipidemia rats
Authors: Santosa Budi , Ayu Eka Cahyani Anak Agung , Mukaromah Ana Hidayati , Adhipireno Purwanto , Ayuningtyas Rr. Annisa , Nur Damayanti Fitriani , Poddar Sandeep
Published: August 2023

Introduction: This study aimed to assess the effects of increasing biotin concentrations on lipid profiles, CRP, and foam cells in Wistar rats with dyslipidemia risks. Materials and Methods: Thirty male Wistar rats (weighing 150-200grams) were divided into five groups and adapted for seven days. The negative control group received standard feed, while the positive control group received a high-fat diet. The treatment groups 1, 2, and 3 received a high-fat diet and biotin at different doses: 1.232mg/kg, 68.39mg/kg, and 97.72mg/kg, respectively, for six weeks. This study employed the colorimetric enzymatic method to examine the lipid profiles, a qualitative approach to examine the CRP, and painting Oil Red O and HE on histology slides to count the foam cells. Results: The negative control group indicated normal levels of lipid profiles and foam cells. The positive control group showed increased lipid profile levels and foam cells. Meanwhile, the treatment groups receiving an increase in biotin concentration showed a decreasing pattern of the foam cells, and their lipid profile levels (total cholesterol, triglycerides, and LDL) decreased. However, the HDL did not reduce. The results of all groups' CRP were negative. The one-way ANOVA test showed significance for the levels of total cholesterol, triglycerides, and LDL. The Kruskal-Wallis test was significant for the number of foam cells (a confidence level of 95%). Conclusion: The biotin treatment significantly improves Wistar rats' lipid profiles and the number of foam cells. However, the doses did not statistically affect the levels of HDL and CRP.
Acute Lymphoblastic Leukaemia (ALL) with History of Juvenile Idiopathic Arthritis (JIA)
Authors: Sri Lestari Ni Nyoman , Wande I Nyoman , Putri Wirawati Ida Ayu
Published: August 2023

Backgrounds: Distinguishing leukemia from Juvenile Idiopathic Arthritis (JIA) is sometimes very difficult. Children with leukemia can also present with complaints of the bones and muscles and many children with leukemia initially present without blast cells in the peripheral blood. Case Reports: A boy aged 8 years 7 months with complaints of joint pain since 6 months before he was admitted to the hospital. Pain was felt intermittently, there was no complaint of fever or bleeding. physical examination, blood pressure 100/70mmHg, pulse 100times/minute, respiratory rate 24times/minute, temperature 36.70C, obtained anemia and splenomegaly. Laboratory tests showed WBC 242.00 x 103/μL, absolute lymphocytes 98.60 x 10 3/μL, RBC 1.54 x 106/μL, HGB 6.02g/dL, PLT 78.09 x 103/μL, CRP 21.65mg/dL, ANA(IF )# negative, RF negative, C3 Complement 150.6mg/dL. Bone Marrow Aspiration (BMA) Acute Lymphoblastic Leukemia (ALL) L2. Conclusion: A boy aged 8 years and 7 months with an initial diagnosis of Juvenile Idiopathic Arthritis, after 3 months of treatment the patient was diagnosed with acute lymphoblastic leukemia based on the results of bone marrow aspiration examination. Currently the patient is undergoing a Leukemia therapy protocol.
Development and Validation of Derivative UV Spectrophotometric method for Simultaneous Determination of Amoxicillin and Clavulanic acid in Tablets (Augmentin 1000mg)
Authors: Mohammad Marah , Sliman Faten , Barakat Hala
Published: August 2023

The simultaneous analysis of pharmaceutical mixtures by classical spectrophotometric methods without prior separation is a challenge owing to the strong overlapping of their zero order spectra (low selectivity). Hence, several techniques have been developed for solving this problem, such as derivative spectrophotometry. The aim of this study was to develop a simple, fast, accurate, precise, economical, and eco-friendly derivative spectrophotometric method for the quantitative determination of a binary mixture of amoxicillin (Amox) and clavulanic acid (Clav) without prior separation steps. The developed method is based on the use of first derivative spectra resulting from derivatisation of zero order, with using these parameters (d𝛌=4 and scaling factor=15). The measurements were achieved by using zero-crossing technique (𝛌= 278.5nm for Amox and 𝛌= 228.3nm for Clav), which eliminated the overlapping caused by two drugs and excipients of tablets. The method showed significant linearity in the range (5 45μg/ml with =0.9998) and (1 - 10μg/ml with =0.9986) for Amox and Clav, respectively. The developed technique was validated according to the ICH guidelines. The method was successfully utilized for the simultaneous determination of Amox and Clav in the formulation. The obtained results were statistically compared with the reported method (HPLC) by applying t-test and F-value at 95% confidence level. No significant difference was observed regarding accuracy and precision. Hence,the proposed procedure can be utilized for regular quality control studies as alternative to chromatographic techniques.
Polysaccharide-Based Formulations for the Treatment of Diabetic Wounds: A Review
Authors: Zainuddin Siti Zuhairah , Muhammad Ridzwan Ramond Nur Jemaima , Anuar Nor Khaizan
Published: August 2023

This article highlights recent progress in the development of polysaccharide-based formulations for the treatment of diabetic wounds. Wound healing is generally slower in diabetic patients than in non-diabetic individuals, which can be complicated into cellulitis, gangrene and foot abscess. Here, the influence of diabetes on the wound healing process and the potential effects of polysaccharide-based formulations on wounds associated with diabetes mellitus are described. Polysaccharides are excellent candidates for effective skin repair due to the characteristics of biodegradability, biocompatibility, and non-toxicity. Common polysaccharides employed in the development of diabetic wound care include cellulose, hyaluronic acid, and alginate. In addition, novel polysaccharides for diabetic wound care have been extracted from natural materials used for traditional medicine, such as Ganoderma lucidum, Periplaneta americana, and psyllium seed husk. Several strategies have been adopted, including crosslinking, grafting, quaternation, nanoformulation, and polymeric composites, to improve the physicochemical and mechanical attributes of polysaccharide-based formulations. These properties are crucial to the wound healing process by facilitating wound closure via accelerated re-epithelialization and collagen synthesis, as well as maintaining an optimal moist environment while minimizing the risk of infection and scar formation. The roles of stimuli-responsive polymers, controlled-release formulations, and bioactive polysaccharides in facilitating diabetic wound healing are also discussed.
Correlation between dysbiosis and incidence of gastrointestinal cancers
Authors:   Ain Shams University, Cairo, Egypt., Ali Sabri Nagwa
Published: August 2023

Background: The human gastrointestinal tract (GIT) population of almost 200 common bacteria, viruses, and fungi supplies the host with distinct metabolic activities and is critical in health and illness state.
Acetamiprid induced oxidative stress and genotoxicity in male albino rats: Attenuation by ambroxol
Authors:   Alexandria University, El-Din Eslam M Ezz
Published: August 2023

The present study was undertaken to evaluate the oxidative stress and genotoxicity induced by 43.40 mg/kg/day of acetamiprid
An uncommon mediastinitis from infected pancreatic pseudocyst
Authors:   CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000 Rennes, France., Philippe Seguin
Published: August 2023

A 48-year-old man with a history of alcoholism and recurrent abdominal pain developed acute alcohol-induced pancreatitis
Determining the factors that predict the feasibility of one-stage primary esophageal repair versus staged repair in neonates with type C esophageal atresia: Developing some new criteria
Authors:   Alexandria University, Egypt., Elrouby Ahmed
Published: August 2023

Background: Several factors can predict the feasibility of primary repair or a staged repair should be done from the start in patients with esophageal atresia with distal tracheoesophageal fistula (Type C TEF) to avoid unnecessary lengthy operations which may result in high morbidity and mortality in such condition.
Is esomeprazole safe and effective in neonatal gastroesophageal reflux disease? A clinical trial
Authors:   Bahrami Children Hospital, Shahid Kiai St., Damavand Ave., Tehran, Iran, A Taheri Peymaneh
Published: August 2023

Introduction: Gastroesophageal reflux disease (GERD) is present in pediatric patients when reflux of gastric contents causes troublesome symptoms
Torsion of congenital ovarian cyst in association with mid-gut volvulus: A rare presentation
Authors:   Faculty of Medicine, Alexandria University, Egypt., Elrouby Ahmed
Published: August 2023

Midgut volvulus is a life-threatening condition that can lead to bowel ischemia and devastating results with high mortality incidence.
On Navo’i’s Ancestors
Authors:   Alisher Navo'i Tashkent State University of Uzbek Language and Literature, Sirojiddinov Shuhrat
Published: August 2023

In the available sources there is almost no information which might produce a full impression of Alisher Navoi’s ancestors. The poet himself said a sentence or two when the subject required. The informa- tion presented in the works of his contemporaries is fragmentary and, in some cases, logically not connected with one another. This article provides a comparative analysis of the information in the manuscript sources and introduces first initial views on the great poet and statesman’s relations with his ancestors and his relationship and position regarding the Timu-rids.