bluuebunny/crossref_metadata_2025 huggingface dataset:
Catgut embedding in acupoints combined with repetitive transcranial magnetic stimulation for the treatment of postmenopausal osteoporosis: study protocol for a randomized clinical trial
Authors: Qiu Jingjing , Xu JiaZi , Cai Yingyue , Li Minghong , Peng Yingsin , Xu Yunxiang , Chen Guizhen
Published: March 2024

Background

To date, the clinical modulation for bone metabolism based on the neuro-bone mass regulation theory is still not popular. The stimulation of nerve systems to explore novel treatments for Postmenopausal osteoporosis (PMOP) is urgent and significant. Preliminary research results suggested that changes brain function and structure may play a crucial role in bone metabolism with PMOP. Thus, we set up a clinical trial to investigate the effect of the combination of repetitive transcranial magnetic stimulation (rTMS) and catgut embedding in acupoints (CEA) for PMOP and to elucidate the central mechanism of this neural stimulation in regulating bone metabolism.

Method

This trial is a prospective and randomized controlled trial. 96 PMOP participants will be randomized in a 1:1:1 ratio into a CEA group, an rTMS group, or a combined one. Participants will receive CEA, rTMS, or combined therapy for 3 months with 8 weeks of follow-up. The primary outcomes will be the changes in Bone Mineral Density scores, total efficiency of Chinese Medicine Symptoms before and after treatment. Secondary outcomes include the McGill Pain Questionnaire Short-Form, Osteoporosis Symptom Score, Mini-Mental State Examination, and Beck Depression Inventory-II. The leptin, leptin receptor, and norepinephrine levels of peripheral blood must be measured before and after treatment. Adverse events that occur during the trial will be recorded.

Discussion

CEA achieves brain-bone mass regulation through the bottom-up way of peripheral-central while rTMS achieves it through the top-down stimulation of central-peripheral. CEA combined with rTMS can stimulate the peripheral-central at the same time and promote peripheral bone mass formation. The combination of CEA and rTMS may play a coordinating, synergistic, and side-effect-reducing role, which is of great clinical significance in exploring better treatment options for PMOP.

Clinical trial registration: https://www.chictr.org.cn/, identifier ChiCTR2300073863.
Down-sampling in diffusion MRI: a bundle-specific DTI and NODDI study
Authors: Spagnolo Federico , Gobbi Susanna , Zsoldos Enikő , Edde Manon , Weigel Matthias , Granziera Cristina , Descoteaux Maxime , Barakovic Muhamed , Magon Stefano
Published: March 2024

Introduction

Multi-shell diffusion Magnetic Resonance Imaging (dMRI) data has been widely used to characterise white matter microstructure in several neurodegenerative diseases. The lack of standardised dMRI protocols often implies the acquisition of redundant measurements, resulting in prolonged acquisition times. In this study, we investigate the impact of the number of gradient directions on Diffusion Tensor Imaging (DTI) and on Neurite Orientation Dispersion and Density Imaging (NODDI) metrics.

Methods

Data from 124 healthy controls collected in three different longitudinal studies were included. Using an in-house algorithm, we reduced the number of gradient directions in each data shell. We estimated DTI and NODDI measures on six white matter bundles clinically relevant for neurodegenerative diseases.

Results

Fractional Anisotropy (FA) measures on bundles where data were sampled at the 30% rate, showed a median L1 distance of up to 3.92% and a 95% CI of (1.74, 8.97)% when compared to those obtained at reference sampling. Mean Diffusivity (MD) reached up to 4.31% and a 95% CI of (1.60, 16.98)% on the same premises. At a sampling rate of 50%, we obtained a median of 3.90% and a 95% CI of (1.99, 16.65)% in FA, and 5.49% with a 95% CI of (2.14, 21.68)% in MD. The Intra-Cellular volume fraction (ICvf) median L1 distance was up to 2.83% with a 95% CI of (1.98, 4.82)% at a 30% sampling rate and 3.95% with a 95% CI of (2.39, 7.81)% at a 50% sampling rate. The volume difference of the reconstructed white matter at reference and 50% sampling reached a maximum of (2.09 ± 0.81)%.

Discussion

In conclusion, DTI and NODDI measures reported at reference sampling were comparable to those obtained when the number of dMRI volumes was reduced by up to 30%. Close to reference DTI and NODDI metrics were estimated with a significant reduction in acquisition time using three shells, respectively with: 4 directions at a b value of 700 s/mm2, 14 at 1000 s/mm2, and 32 at 2000 s/mm2. The study revealed aspects that can be important for large-scale clinical studies on bundle-specific diffusion MRI.
Repeat hepatectomy versus thermal ablation therapy for recurrent hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Dong Renhua , Zhang Ting , Wan Wenwu , Zhang Hao
Published: March 2024

Background

This meta-analysis was conducted to assess the survival benefits of repeat hepatectomy (RH) and thermal ablation therapy (TAT) in managing recurrent hepatocellular carcinoma (HCC).

Methods

A comprehensive search was conducted in the PubMed, SinoMed, Embase, Cochrane Library, Medline, and Web of Science databases using relevant keywords to identify all studies published on this specific topic. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were estimated using a fixed-effects model.

Results

This meta-analysis included a total of 21 studies, comprising 2580 patients with recurrent HCC, among whom 1189 underwent RH and 1394 underwent TAT. Meta-analysis results demonstrated that the RH group exhibited superior overall survival (OS) (HR=0.85, 95%CI 0.76∼0.95, P=0.004) and recurrence-free survival (RFS) (HR=0.79, 95%CI 0.7∼0.9, P<0.01) compared to the TAT group. Regarding postoperative complications, the TAT group experienced fewer complications than the RH group (OR=3.23, 95%CI 1.48∼7.07, P=0.003), while no significant difference in perioperative mortality was observed between the two groups (OR=2.11, 95%CI 0.54∼8.19, P=0.28).

Conclusion

The present study demonstrates that, in comparison to TAT, RH may confer superior survival benefits for patients with recurrent HCC.
Cognitive impairment assessment through handwriting (COGITAT) score: a novel tool that predicts cognitive state from handwriting for forensic and clinical applications
Authors: Balestrino Maurizio , Brugnolo Andrea , Girtler Nicola , Pardini Matteo , Rizzetto Cristiano , Alì Paolo Alessandro , Cocito Leonardo , Schiavetti Irene
Published: March 2024

Introduction

Handwriting deteriorates proportionally to the writer’s cognitive state. Such knowledge is of special importance in the case of a contested will, where dementia of the testator is claimed, but medical records are often insufficient to decide what the testator’s cognitive state really was. By contrast, if the will is handwritten, handwriting analysis allows us to gauge the testator’s cognitive state at the precise moment when he/she was writing the will. However, quantitative methods are needed to precisely evaluate whether the writer’s cognitive state was normal or not. We aim to provide a test that quantifies handwriting deterioration to gauge a writer’s cognitive state.

Methods

We consecutively enrolled patients who came for the evaluation of cognitive impairment at the Outpatient Clinic for Cognitive Impairment of the Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Sciences (DINOGMI) of the University of Genoa, Italy. Additionally, we enrolled their caregivers. We asked them to write a short text by hand, and we administered the Mini Mental State Examination (MMSE). Then, we investigated which handwriting parameters correlated with cognitive state as gauged by the MMSE.

Results

Our study found that a single score, which we called the COGnitive Impairment Through hAndwriTing (COGITAT) score, reliably allows us to predict the writer’s cognitive state.

Conclusion

The COGITAT score may be a valuable tool to gage the cognitive state of the author of a manuscript. This score may be especially useful in contested handwritten wills, where clinical examination of the writer is precluded.
Promoting post-traumatic growth in cancer patients: a randomized controlled trial of guided written disclosure
Authors: Cafaro Valentina , Rabitti Elisa , Artioli Giovanna , Costantini Massimo , De Vincenzo Francesco , Franzoni Francesca , Cavuto Silvio , Bertelli Tatiana , Deledda Giuseppe , Piattelli Angela , Cardinali Lisa , De Padova Silvia , Poli Sara , Iuvaro Maria Domenica , Fantoni Giovanna , Di Leo Silvia
Published: March 2024

Background

Cancer is a life-threatening disease that triggers not only vulnerability to distressing symptoms but also a meaning-making process that may lead to post-traumatic growth. As people often struggle to integrate cancer illness into their meaning system to reach an adaptive meaning, psychological interventions focused on a reappraisal of the illness experience can facilitate this process. This multicenter randomized controlled trial (RCT) was primarily aimed at assessing the efficacy of a writing intervention known as a guided disclosure protocol (GDP), compared to a generic writing intervention, in promoting post-traumatic growth in stage I-III breast and colon cancer patients at the end of their adjuvant chemotherapy.

Methods

Between January 2016 and August 2020 recruitment of eligible subjects took place during follow-up clinical consultations. Assessment occurred at baseline (T0), after the intervention (T1, 3 months from baseline), and at 6 months from baseline (T2). Both interventions consisted of three 20-min writing sessions to be performed once every two weeks. Change in post-traumatic growth was assessed using the Posttraumatic Growth Inventory, meaning with the Constructed Meaning Scale, and psychological distress with the Impact of Event Scale and the Hospital Anxiety and Depression Scale.

Results

In the five participating centers, 102 eligible patients were randomized and 72 participants completed follow-up evaluation. Most patients were women (79.4%), had breast cancer (68.6%), and stage I (27.5%), or stage II (44.1%) disease. Mean differences did not reach statistical significance for any of the dependent variables. However, an effect of the GDP, although not statistically relevant, was observed after the intervention in terms of enhanced post-traumatic growth and increased distress measured with the Impact of Event Scale.

Conclusion

This is the first RCT investigating the efficacy of a GDP in cancer patients having post-traumatic growth as the primary aim. Though GDP is a promising intervention in promoting post-traumatic growth, the lack of statistical significance of our findings may be due to the study being underpowered, hence this trial should be replicated with an adequate sample size, paying attention to supporting recruitment.

Clinical trial registration: ClinicalTrials.gov, identifier: 2015/0024360.
Measuring resilience for Chinese-speaking populations: a systematic review of Chinese resilience scales
Authors: Tian Zhenyu , Kuang Kai , Wilson Steven R. , Buzzanell Patrice M. , Ye Jinyi , Mao Xinyue , Wei Hai
Published: March 2024

Introduction

Despite the rapid growth of interdisciplinary resilience research in Chinese contexts, no study has systematically reviewed individual-level measurement scales for Chinese-speaking populations. We report a systematic review of scales developed for or translated/adapted to Chinese-speaking contexts, where we assessed how widely used scales fare in terms of their psychometric qualities.

Methods

Studies included in this review must have been published in peer-reviewed English or Chinese journals between 2015-2020 and included self-reported resilience scales in Chinese-speaking populations. Searches were conducted in PsycINFO, CNKI (completed in May 2021), and PubMed (completed in January 2024). We developed coding schemes for extracting relevant data and adapted and applied an existing evaluation framework to assess the most frequently used resilience scales by seven methodological criteria.

Results

Analyses of 963 qualified studies suggested that Chinese resilience scales were used in a diverse range of study contexts. Among 85 unique kinds of resilience measures, we highlighted and evaluated the three most frequently used translated scales and three locally developed scales (nine scales in total including variations such as short forms). In short, resilience studies in Chinese contexts relied heavily on the translated 25-item Connor-Davidson Resilience Scale, which scored moderately on the overall quality. The locally developed Resilience Scale for Chinese Adolescents and Essential Resilience Scale received the best ratings but could use further development.

Discussion

We discussed how future work may advance widely used scales, and specified seven methodological recommendations for future resilience scale development with existing and new scales in and beyond the Chinese study contexts. We further addressed issues and challenges in measuring resilience as a process and called on researchers to further develop/evaluate process measures for Chinese-speaking populations.
Reliability and validity estimation of Urdu version of Children Emotion Management Scales (CEMS) in Pakistan
Authors: Baig Khawer Bilal , Sadia Haleema , Rauf Umara , Abbas Qasir , Ramzan Zoobia , Tabassum Urooj , Aljhani Sumayah
Published: March 2024

Introduction

The present study aimed to translate and validate Children's Emotion Management Scales into Urdu, the national language of Pakistan.

Method

The current study comprised three different phases, i.e., phase I: Cross-language validation over a sample of (N = 169) school children, estimated at a 1-week interval.

Results

The results indicate a significant correlation (r = 0.846–0.891) at p < 0.01. In phase II, the internal consistency reliability (r = 0.808–0.904) and split-half reliability (r = 0.737–0.898) of the scale were assessed (N = 683) at p < 0.01. Furthermore, significant results for test-retest reliability analysis (N = 168) were obtained (r = 0.736–0.917 at p < 0.01), following the confirmatory factor analysis (CFA) (N = 1,083). Exploratory factor analysis (EFA) was conducted on the same sample chosen for CFA. EFA resulted in the retention of original inhibition (INH), dysregulated expression (DYS), and emotional coping (EMO) factors. CFA findings suggest a good model fit. In phase III, convergent validity and divergent validity were checked (N = 385, 255, and 213). Convergent validity of INH and DYS subscales and divergent validity of EMO subscales were established, with SBI (r = 0.217–0.609; 0.210–0.445; −0.026 to −0.553), SHS (r = 0.417–0.441; 0.480–0.546; −0.338 to −0.582), and suppression subscale of ERQ (r = 0.430–0.480; 0.468–0.522; −0.245 to −0.369) at p < 0.01. For divergent validity of INH and DYS subscales and convergent validity of EMO subscales, their scores were correlated with the SPS (r = −0.204 to −0.350; −0.318 to −0.459; 0.191–0.531), RSE Scale (r = −0.226 to −0.351; −0.279 to −0.352; 0.255–0.507), DTS (−0.290 to −0.617; −0.369 to −0.456; 0.246–0.680), and reappraisal subscale of ERQ (r = −0.456 to −0.541; −0.329 to −0.544; 0.446–0.601) at p < 0.01.

Discussion

It is concluded that the scale is reliable and valid with sound psychometric properties.
Meta-analysis of association between caesarean section and postpartum depression risk
Authors: Ning Jiajie , Deng Jing , Li Shanshan , Lu Caina , Zeng Pingping
Published: March 2024

Background

The association of caesarean section (CS) for postpartum depression (PPD) remains controversial. This study aims to explore the relationship between CS and the risk of PPD, in order to provide a basis for preventing PPD.

Material and methods

We searched PubMed, Web of Science, Cochrane Library, and EMBASE databases for literature about the correlation between CS and PPD published as of February 2024. The combined odds ratios (ORs) and 95% confidence intervals (Cls) were obtained by flexible use of fixed-effects models or random-effects models.

Results

A total of 18 publications were ultimately included in the analysis. Among these, 14 were cohort studies and 4 were case-control reports, encompassing 844,328 total cases. All of the included studies were deemed to be of moderate or higher quality. The meta-analysis indicated that the prevalence of PPD among parturients undergoing CS was 13.4% (95% CI: 6.5%-25.5%).The adjusted odds ratio (OR) for the association between CS and PPD was 1.12 (95% CI: 1.04-1.20) compared to the natural vaginal delivery (NVD) group. Specifically, the adjusted OR for the association between CS and PPD was 1.29 (95% CI: 1.18-1.40) during the first 1-6 months postpartum, and 1.23 (95% CI: 1.14-1.33) after 6 months postpartum. Furthermore, in comparison to the NVD group, the adjusted OR for elective caesarean section (ELCS) and emergency caesarean section (EMCS) were 0.96 (0.83, 1.10) and 1.20 (1.08, 1.34), respectively.

Conclusion

Our findings suggest that PPD risk may rise in the presence of CS. In particular, the risk was increased by 20% in the EMCS group, and the risk of PPD within one to six months postpartum after CS increases by 6% compared to that at six months postpartum. In the future, more rational designs and in-depth studies are needed to obtain more accurate information.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42023389265.
You are not like the rest of them: disrupting meta-perceptions dilutes dehumanization
Authors: Carriere Kevin R. , Hallenbeck Gregory , Sullivan Delaney , Ghion Rebecca
Published: March 2024

Political polarization, fueled by conflicting meta-perceptions, presents a critical obstacle to constructive discourse and collaboration. These meta-perceptions-how one group perceives another group's views of them-are often inaccurate and can lead to detrimental outcomes such as increased hostility and dehumanization. Across two studies, we introduce and experimentally test a novel approach that exposes participants to atypical, counter-stereotypical members of an opposing group who either confirm or disrupt their existing meta-perceptions. We find that disrupting meta-perceptions decreases dehumanization of the partner, increases interest in wanting to learn more about them, but fails to increase willingness to interact in the future with the partner. We conduct an exploratory text analysis to uncover differences in word choice by condition. Our research adds a new dimension to the existing body of work by examining the efficacy of alternative intervention strategies to improve intergroup relations in politically polarized settings.
Detection of antibodies against Ornithodoros moubata salivary antigens and their association with detection of African swine fever virus in pigs slaughtered in central Uganda
Authors: Kayaga Edrine B. , Wampande Eddie M. , Ekakoro John E. , Okwasiimire Rodney , Nassali Aisha , Ochoa Krista , Hauser Cole , Ndoboli Dickson , Havas Karyn A.
Published: March 2024

Introduction

African swine fever (ASF) is an important disease of pigs in sub-Saharan Africa and Uganda and is threatening the pig population and agricultural economy of other continents. ASF virus (ASFV) can be transmitted from wild suids to domestic pigs through soft ticks of the Ornithodoros species. The aim of this study was to understand the relationship between domestic pigs’ O. moubata tick exposure and ASFV status.

Methods

Pigs were sampled from six abattoirs in the Kampala metropolitan area of Uganda from May 2021 through June 2022. Blood, serum, and tissue samples were collected. Serum was tested for antibodies against the rtTSGP1 salivary antigens of O. moubata ticks using an indirect ELISA assay. Blood and tissue samples from pigs were tested to detect ASFV using qPCR. Probability of tick exposure was categorized based on sample-to-positive ratio cut-off points.

Results

Out of 1,328 serum samples tested, there were 828 (62.3%) samples with a negligible probability; 369 (27.8%) with a medium probability; 90 (6.8%) with a high probability, and 41 (3.1%) with a very high probability of exposure to the O. moubata salivary antigen. There was a statistically significant association between the pigs’ O. moubata exposure and ASFV status with a higher proportion of pigs having a very high probability of infection if they were ASFV positive by blood, tonsil, and lymph nodes.

Discussion

These results suggested that tick exposure was associated with ASFV transmission in Uganda. There were ASFV qPCR positive pigs that had no O. moubata exposure as well, which highlights that pig-to-pig and indirect contact transmission still play a significant role. This work highlights the need for further work in Uganda to investigate these transmission factors related to the O. moubata tick and ASFV transmission.
Small animal patient preoperative preparation: a review of common antiseptics, comparison studies, and resistance
Authors: Nye Alicia K. , Thieman Mankin Kelley M.
Published: March 2024

This review aims to describe commonly used antiseptics in veterinary medicine including their mechanism of action, spectrum of activity, potential adverse effects, and application techniques. Additionally, it provides a review of the veterinary literature comparing antiseptics, a discussion of effectiveness and efficacy studies, and the potential for increased resistance to biocides and antimicrobials. This review concludes that appropriate selection and use is necessary to prevent the occurrence of surgical site infections, adverse effects, and potential for increasing resistance to antimicrobials. Continued research is needed to fill gaps in the current knowledge such as optimal preparation procedures for various surgical sites, standardization of efficacy and effectiveness testing, and the clinical impact of decreased susceptibility to chlorhexidine and other antiseptics.
Entropy-Based Methods for Motor Fault Detection: A Review
Authors: Aguayo-Tapia Sarahi , Avalos-Almazan Gerardo , Rangel-Magdaleno Jose de Jesus
Published: March 2024

In the signal analysis context, the entropy concept can characterize signal properties for detecting anomalies or non-representative behaviors in fiscal systems. In motor fault detection theory, entropy can measure disorder or uncertainty, aiding in detecting and classifying faults or abnormal operation conditions. This is especially relevant in industrial processes, where early motor fault detection can prevent progressive damage, operational interruptions, or potentially dangerous situations. The study of motor fault detection based on entropy theory holds significant academic relevance too, effectively bridging theoretical frameworks with industrial exigencies. As industrial sectors progress, applying entropy-based methodologies becomes indispensable for ensuring machinery integrity based on control and monitoring systems. This academic endeavor enhances the understanding of signal processing methodologies and accelerates progress in artificial intelligence and other modern knowledge areas. A wide variety of entropy-based methods have been employed for motor fault detection. This process involves assessing the complexity of measured signals from electrical motors, such as vibrations or stator currents, to form feature vectors. These vectors are then fed into artificial-intelligence-based classifiers to distinguish between healthy and faulty motor signals. This paper discusses some recent references to entropy methods and a summary of the most relevant results reported for fault detection over the last 10 years.
Combustion Behaviors, Kinetics, and Thermodynamics of Naturally Decomposed and Torrefied Northern Red Oak (Quercus rubra) Forest Logging Residue
Authors: Hu Wanhe , Wang Jingxin , Hu Jianli , Schuler Jamie , Grushecky Shawn , Jiang Changle , Smith William , Nan Nan , Sabolsky Edward M.
Published: March 2024

Torrefaction and combustion have been applied to naturally decomposed red oak logging residues. The results indicated that four-year natural decomposition would lower the energy density of red oak from 20.14 to 18.85 MJ/kg. Torrefaction reduced the O/C and H/C ratios but improved the energy yield values. Two combustion stages were observed for all samples, and no hemicellulose derivative thermogravimetric peak appeared for torrefied samples. The differential scanning calorimetry exothermic heat flow increased after torrefaction. In addition, the Kissinger–Akahira–Sunose average activation energy of untorrefied samples decreased in the first stage (from 157.77 to 149.52 KJ/mol), while it increased in the second stage (from 131.32 to 181.83 KJ/mol). The ∆H, ∆G, and ∆S values of all samples decreased in the first stage, while they increased when the conversion rate was greater than 0.5 for torrefied samples. These findings can aid in a better understanding of the fuel performance of torrefied and untorrefied naturally decomposed red oak logging residues.
A Novel 1D Approach for Modelling Gas Bladder Suppressors on the Delivery Line of Positive Displacement Pumps
Authors: Casoli Paolo , Vescovini Carlo Maria , Masoud Hatami Garousi , Rundo Massimo
Published: March 2024

This paper concerns the utilisation of a gas bladder hydraulic suppressor to mitigate oscillations in the delivery flow rate of positive displacement machines. The research focuses on two primary objectives: first, the experimental validation of the potential of this solution and second, the formulation of a one-dimensional fluid dynamic model for the suppressor. The foundational framework of the fluid dynamic model is based on the equations governing fluid motion with a one-dimensional approach. To accurately depict the fluid dynamics within the suppressor, a unique approach for determining the speed of sound was incorporated, and it implemented the instantaneous cross-sectional area and the inertial effect of the bladder. This paper is a development of a previous work to also investigate the positioning along the delivery pipe of the suppressor with respect to the pump. The study presents the performance of the suppressor and points out the effects of its relative position with respect to the pump that becomes particularly relevant at high speeds.
Reduction in Emissions by Massive Solar Plant Integration in the US Power Grid
Authors: Soto Esteban A. , Wollega Ebisa , Vizcarrondo Ortega Alexander , Hernandez-Guzman Andrea , Bosman Lisa
Published: March 2024

Fossil fuels, the predominant energy source in the United States, have been identified as major contributors to environmental pollution through the release of harmful emissions. As a countermeasure, there has been an increasing focus on the exploration and development of cleaner energy alternatives to alleviate the environmental degradation caused by fossil fuels and to satisfy the growing energy needs. This study conducted scenario analyses to evaluate the impact of integrating solar energy into specific US power grids on reducing carbon emissions. The analysis encompassed electrical systems within California, New England, New York, and the Southwest, utilizing datasets from the Energy Information Administration and National Renewable Energy Laboratory. The Energy Information Administration dataset includes information on net generation according to each source and carbon emissions according to fuel type, whereas the National Renewable Energy Laboratory dataset provides hourly projections for 6000 theoretical photovoltaic installations and detailed solar energy output data every five minutes over a year. Our findings indicated a notable decrease in carbon dioxide emissions following the introduction of solar power facilities. The most significant reductions were observed in the Southwest and California, attributed to solar plant integration. Conversely, New York and New England were identified as regions requiring additional policy measures and incentives to meet the emission reduction goals.
Catalytic Pyrolysis of Naomaohu Coal Using Combined CaO and Ni/Olivine Catalysts for Simultaneously Improving the Tar and Gas Quality
Authors: Tursun Yalkunjan , Wang Ke , Yi Runxiao , Abduhani Hairat , Dai Zhenghua , Zhong Mei , Jin Lijun , Li Jian , Liu Yang
Published: March 2024

Catalytic pyrolysis of low-rank coal is currently an effective method for producing high-quality tar and gas. In this study, catalytic upgrading of volatiles from Naomaohu (NMH) coal pyrolysis has been conducted in a two-stage fixed-bed reactor using combined CaO and Ni/olivine (Ni-loaded olivine) catalysts. The effect of catalyst distribution modes and catalytic temperature on the tar and gas quality has been investigated. Simulated distillation and GC-MS analysis have been used to investigate the distribution of tar components. The results indicated that the light oil fraction in tar dramatically increased due to the combination of CaO and Ni/olivine. The CaO-Ni/olivine mode is especially better compared to the layouts of the Ni/olivine-CaO mode and the mixed mode. The CaO-Ni/olivine mode ensures a higher light fraction in tar at 69.3% and a light oil fraction at 29.8% at a catalytic temperature of 450 °C, while the heavy tar fraction decreased to 30.7%. Meanwhile, the contents of benzene (heteroatomic substituents) in tar significantly increased from 2.55% to 6.45% compared with the blank test. In this scenario, CaO breaks down macromolecular compounds in tar and cleaves long-chain esters to produce aliphatic hydrocarbons. These hydrocarbons are then dehydrogenated to produce lighter aromatic hydrocarbons over the CaO surface. Subsequently, the volatiles pass through the Ni/olivine catalysis, where ether compounds are produced by means of dehydration reactions. In addition, the CaO absorbs the CO2 in the pyrolysis gas, leading to an elevation of CH4 and H2 concentration. Particularly, the concentration of H2 significantly increased from 16.2% to 30.37%, while the concentration of CO2 significantly decreased from 37.9% to 10.57%. These findings suggest that the usage of combined CaO and Ni/olivine catalysts is beneficial for improving both the tar and gas quality.
Optimizing the Charging Mobility of WPT-Enabled UAV to Enhance the Stability of Solar-Powered LoRaWAN IoT
Authors: Gong Yujin , Yoon Ikjune , Noh Dong Kun
Published: March 2024

In the majority of Internet of Things (IoT) applications, persistent and stable operation is a crucial requirement. While environmental energy-harvesting technologies can enhance IoT’s persistence, they do not guarantee stability. Therefore, we aim to address the stability challenges in solar-powered IoT (SP-IoT) by employing wireless power transmission (WPT) through unmanned aerial vehicles (UAVs). This study focuses on determining the optimal charging mobility of drones for WPT to enhance the stability of nodes operating in a wide area network (WAN)-based SP-IoT environment. The proposed scheme identifies nodes with insufficient solar energy harvesting and defines the optimal charging mobility parameters (hovering position, hovering time, and moving path) to efficiently transmit the drone’s energy to these nodes in a balanced manner. The experimental results confirm that the proposed scheme significantly improves the stability of solar-powered IoT nodes by optimally utilizing the limited energy of the drone.
Simulation of Underground Coal-Gasification Process Using Aspen Plus
Authors: Yuan Shuxia , Jiao Wanwan , Wang Chuangye , Wu Song , Jiang Qibin
Published: March 2024

In order to study the underground coal-gasification process, Aspen Plus software was used to simulate the lignite underground gasification process, and a variety of unit operation modules were selected and combined with the kinetic equations of coal underground gasification. The model can reflect the complete gasification process of the coal underground gasifier well, and the simulation results are more in line with the experimental results of the lignite underground gasification model test. The changes in the temperature and pressure of oxygen, gasification water, spray water, and syngas in pipelines were studied, and the effects of pipe diameters on pipeline conveying performance were investigated as well. The effects of the oxygen/water ratio, processing capacity, and spray-water volume on the components of syngas and components in different reaction zones were studied. In addition, the change tendency of gasification products under different conditions was researched. The results indicate that: (1) The depth of injection and the formation pressure at that depth need to be taken into account to determine a reasonable injection pressure. (2) The liquid-water injection process should select a lower injection pressure. (3) Increasing the oxygen/water ratio favors H2 production and decreasing the oxygen/water ratio favors CH4 production. (4) The content of CO2 is the highest in the oxidation zone, the lowest in the reduction zone, and then increases a little in the methanation reaction zone for the transform reaction. The content of CO is the lowest in the oxidation zone and the highest in the reduction zone. In the methanation reaction zone, CO partially converts into H2 and CO2, and the content of CO is reduced. (5) The injection of spray water does not affect the components of the gas but will increase the water vapor content in the gas; thus, this changes the molar fraction of the wet gas.
Effect of Rotational Angle of Discrete Inclined Ribs on Horizontal Flow and Heat Transfer of Supercritical R134a
Authors: Yang Genxian , Tang Junrui , Li Zhouhang
Published: March 2024

This work numerically studied the heat transfer and flow characteristics of supercritical R134a in horizontal pipes equipped with DDIR, considering variations in the rotation angle of DDIR. The aim is to improve the effects of the DDIR configuration on the heat transfer of supercritical flow. After validation with experimental data, the AKN model was employed to examine the effects of four sets of rotation angles (0°, 30°, 45°, and 60°) on the axial and circumferential heat transfer characteristics of DDIR horizontal tubes under the influence of strong (q1/G1 = 0.1 kJ/kg) and medium (q2/G2 = 0.056 kJ/kg) buoyancy. Results show that variations in the rotation angle do not induce significant alterations in the flow field, thus exerting minimal influence on the axial heat transfer characteristics. Meanwhile, the rotation angle determines the relative positioning of the circumferential inner wall temperatures and heat flux distribution, although the magnitude of this effect remains inconspicuous. The rotational angle parameter can be reasonably neglected in the future design and installation of heat exchangers.
The Use of Spatially Multi-Component Plasma Structures and Combined Energy Deposition for High-Speed Flow Control: A Selective Review
Authors: Azarova Olga A. , Kravchenko Oleg V.
Published: March 2024

This review examines studies aimed at the organization of energy (non-mechanical) control of high-speed flow/flight using spatially multi-component plasma structures and combined energy deposition. The review covers selected works on the experimental acquisition and numerical modeling of multi-component plasma structures and the use of sets of actuators based on plasma of such a spatial type for the purposes of control of shock wave/bow shock wave–energy source interaction, as well as control of shock wave–boundary layer interaction. A series of works on repetitive multiple laser pulse plasma structures is also analyzed from the point of view of examining shock wave/bow shock wave–boundary layer interaction. Self-sustained theoretical models for laser dual-pulse, multi-mode laser pulses, and self-sustained glow discharge are also considered. Separate sections are devoted to high-speed flow control using combined physical phenomena and numerical prediction of flow control possibilities using thermal longitudinally layered plasma structures. The wide possibilities for organization and applying spatially multi-component structured plasma for the purposes of high-speed flow control are demonstrated.
Generating Synthetic Electricity Load Time Series at District Scale Using Probabilistic Forecasts
Authors: Richter Lucas , Bender Tom , Lenk Steve , Bretschneider Peter
Published: March 2024

Thanks to various European directives, individuals are empowered to share and trade electricity within Renewable Energy Communities, enhancing the operational efficiency of local energy systems. The digital transformation of the energy market enables the integration of decentralized energy resources using cloud computing, the Internet of Things, and artificial intelligence. In order to assess the feasibility of new business models based on data-driven solutions, various electricity consumption time series are necessary at this level of aggregation. Since these are currently not yet available in sufficient quality and quantity, and due to data privacy reasons, synthetic time series are essential in the strategic planning of smart grid energy systems. By enabling the simulation of diverse scenarios, they facilitate the integration of new technologies and the development of effective demand response strategies. Moreover, they provide valuable data for assessing novel load forecasting methodologies that are essential to manage energy efficiently and to ensure grid stability. Therefore, this research proposes a methodology to synthesize electricity consumption time series by applying the Box–Jenkins method, an intelligent sampling technique for data augmentation and a probabilistic forecast model. This novel approach emulates the stochastic nature of electricity consumption time series and synthesizes realistic ones of Renewable Energy Communities concerning seasonal as well as short-term variations and stochasticity. Comparing autocorrelations, distributions of values, and principle components of daily sequences between real and synthetic time series, the results exhibit nearly identical characteristics to the original data and, thus, are usable in designing and studying efficient smart grid systems.
Aquaporins in the Cornea
Authors: Melnyk Samuel , Bollag Wendy B.
Published: March 2024

The cornea is an avascular, transparent tissue that allows light to enter the visual system. Accurate vision requires proper maintenance of the cornea’s integrity and structure. Due to its exposure to the external environment, the cornea is prone to injury and must undergo proper wound healing to restore vision. Aquaporins (AQPs) are a family of water channels important for passive water transport and, in some family members, the transport of other small molecules; AQPs are expressed in all layers of the cornea. Although their functions as water channels are well established, the direct function of AQPs in the cornea is still being determined and is the focus of this review. AQPs, primarily AQP1, AQP3, and AQP5, have been found to play an important role in maintaining water homeostasis, the corneal structure in relation to proper hydration, and stress responses, as well as wound healing in all layers of the cornea. Due to their many functions in the cornea, the identification of drug targets that modulate the expression of AQPs in the cornea could be beneficial to promote corneal wound healing and restore proper function of this tissue crucial for vision.
A Potential Role of Interleukin-5 in the Pathogenesis and Progression of Amyotrophic Lateral Sclerosis: A New Molecular Perspective
Authors: Moțățăianu Anca , Andone Sebastian , Stoian Adina , Bălașa Rodica , Huțanu Adina , Sărmășan Emanuela
Published: March 2024

Cumulative data suggest that neuroinflammation plays a prominent role in amyotrophic lateral sclerosis (ALS) pathogenesis. The purpose of this work was to assess if patients with ALS present a specific peripheral cytokine profile and if it correlates with neurological disability assessed by ALSFRS-R, the rate of disease progression, and the pattern of disease progression (horizontal spreading [HSP] versus vertical spreading [VSP]). We determined the levels of 15 cytokines in the blood of 59 patients with ALS and 40 controls. We identified a positive correlation between levels of pro-inflammatory cytokines (interleukin [IL]-17F, IL-33, IL-31) and the age of ALS patients, as well as a positive correlation between IL-12p/70 and survival from ALS onset and ALS diagnosis. Additionally, there was a positive correlation between the ALSFRS-R score in the upper limb and respiratory domain and IL-5 levels. In our ALS cohort, the spreading pattern was 42% horizontal and 58% vertical, with patients with VSP showing a faster rate of ALS progression. Furthermore, we identified a negative correlation between IL-5 levels and the rate of disease progression, as well as a positive correlation between IL-5 and HSP of ALS. To the best of our knowledge, this is the first study reporting a “protective” role of IL-5 in ALS.
Genome-Wide Identification and Expression Profiling of the ABF Transcription Factor Family in Wheat (Triticum aestivum L.)
Authors: Yang Fuhui , Sun Xuelian , Wu Gang , He Xiaoyan , Liu Wenxing , Wang Yongmei , Sun Qingyi , Zhao Yan , Xu Dengan , Dai Xuehuan , Ma Wujun , Zeng Jianbin
Published: March 2024

Members of the abscisic acid (ABA)-responsive element (ABRE) binding factor (ABF) and ABA-responsive element binding protein (AREB) families play essential roles in the regulation of ABA signaling pathway activity and shape the ability of plants to adapt to a range of stressful environmental conditions. To date, however, systematic genome-wide analyses focused on the ABF/AREB gene family in wheat are lacking. Here, we identified 35 ABF/AREB genes in the wheat genome, designated TaABF1–TaABF35 according to their chromosomal distribution. These genes were further classified, based on their phylogenetic relationships, into three groups (A–C), with the TaABF genes in a given group exhibiting similar motifs and similar numbers of introns/exons. Cis-element analyses of the promoter regions upstream of these TaABFs revealed large numbers of ABREs, with the other predominant elements that were identified differing across these three groups. Patterns of TaABF gene expansion were primarily characterized by allopolyploidization and fragment duplication, with purifying selection having played a significant role in the evolution of this gene family. Further expression profiling indicated that the majority of the TaABF genes from groups A and B were highly expressed in various tissues and upregulated following abiotic stress exposure such as drought, low temperature, low nitrogen, etc., while some of the TaABF genes in group C were specifically expressed in grain tissues. Regulatory network analyses revealed that four of the group A TaABFs (TaABF2, TaABF7, TaABF13, and TaABF19) were centrally located in protein–protein interaction networks, with 13 of these TaABF genes being regulated by 11 known miRNAs, which play important roles in abiotic stress resistance such as drought and salt stress. The two primary upstream transcription factor types found to regulate TaABF gene expression were BBR/BPC and ERF, which have previously been reported to be important in the context of plant abiotic stress responses. Together, these results offer insight into the role that the ABF/AREB genes play in the responses of wheat to abiotic stressors, providing a robust foundation for future functional studies of these genes.
Peeking into the Stingers: A Comprehensive SWATH-MS Study of the European Hornet Vespa crabro (Linnaeus, 1758) (Hymenoptera: Vespidae) Venom Sac Extracts
Authors: Feás Xesús , Alonso-Sampedro Manuela , Bravo Susana Belén , Vidal Carmen
Published: March 2024

This study aimed to investigate the venom sac extracts (VSEs) of the European hornet (EH) Vespa crabro (Linnaeus, 1758) (Hymenoptera: Vespidae), focusing on the differences between stinging females, gynes (G), and workers (W), at the protein level. Using a quantitative “Sequential Window Acquisition of all Theoretical Fragment Ion Mass Spectra” (SWATH-MS) analysis, we identified and quantified a total of 240 proteins. Notably, within the group, 45.8% (n = 110) showed significant differential expression between VSE-G and VSE-W. In this set, 57.3% (n = 63) were upregulated and 42.7% (n = 47) downregulated in the G. Additionally, the two-hundred quantified proteins from the class Insecta belong to sixteen different species, six of them to the Hymenoptera/Apidae lineage, comprising seven proteins with known potential allergenicity. Thus, phospholipase A1 (Vesp v 1), phospholipase A1 verutoxin 2b (VT-2b), hyaluronidase A (Vesp v 2A), hyaluronidase B (Vesp v 2B), and venom allergen 5 (Vesp v 5) were significantly downregulated in the G, and vitellogenin (Vesp v 6) was upregulated. Overall, 46% of the VSE proteins showed differential expression, with a majority being upregulated in G. Data are available via ProteomeXchange with identifier PXD047955. These findings shed light on the proteomic differences in VSE between EH castes, potentially contributing to our understanding of their behavior and offering insights for allergy research.
Pelvic Organ Prolapse Reconstruction with the Chitosan-Based Novel Haemostatic Agent in Ovine Model—Preliminary Report
Authors: Stangel-Wójcikiewicz Klaudia , Murawski Maciej , Schwarz Tomasz , Skotniczny Krzysztof , Fuchs Agnieszka , Wolski Jan , Radwan-Pragłowska Julia , Janus Łukasz , Piątkowski Marek , Kot Marta , Wróbel Andrzej , Wojtysiak Dorota , Urbaniec Przemysław
Published: March 2024

This prospective study aimed to assess the feasibility of chitosan biomaterial and subcutaneous gel implantation in an ovine model, with implications for women with genital prolapse. Twenty-four ewes were divided into four groups (n = 6 per group): chitosan type B, chitosan type C, chitosan unmodified injections, and polypropylene mesh. Ovine models were chosen due to their morphological resemblance to human reproductive organs. Animals were sacrificed after 90 days for macroscopic, pathomorphological, and immunohistochemical analysis. In the chitosan type B group, IL-6 and IL-10 levels decreased after 28 days, while chitosan type C and injection groups exhibited higher IL-6 than IL-10 levels. The polypropylene group displayed the highest IL-6 and lowest IL-10 levels. Histological examination of the polypropylene group revealed no degenerative changes or inflammation, whereas chitosan injection induced local inflammation. Other groups exhibited no degenerative changes. Ewes implanted with chitosan displayed reduced inflammation compared to polypropylene-implanted ewes. Chitosan implantation facilitated vaginal tissue healing, in contrast to polypropylene mesh, which led to extrusion. While chitosan holds promise as an alternative to polypropylene mesh, further research is imperative for comprehensive evaluation. This study suggests the potential of a chitosan biomaterial in pelvic organ prolapse treatment, warranting additional investigation.
SmartLaundry: A Real-Time System for Public Laundry Allocation in Smart Cities
Authors: Portase Raluca Laura , Tolas Ramona , Potolea Rodica
Published: March 2024

Smart cities facilitate the comprehensive management and operation of urban data generated within a city, establishing the foundation for smart services and addressing diverse urban challenges. A smart system for public laundry management uses artificial intelligence-based solutions to solve the challenges of the inefficient utilization of public laundries, waiting times, overbooking or underutilization of machines, balancing of loads across machines, and implementation of energy-saving features. We propose SmartLaundry, a real-time system design for public laundry smart recommendations to better manage the loads across connected machines. Our system integrates the current status of the connected devices and data-driven forecasted usage to offer the end user connected via a mobile application a list of recommended machines that could be used. We forecast the daily usage of devices using traditional machine learning techniques and deep learning approaches, and we perform a comparative analysis of the results. As a proof of concept, we create a simulation of the interaction with our system.