bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Associated with Blood Pressure Checkup During Pregnancy Among Women of Reproductive Age in Tanzania; An Analysis of Data from the 2015-16 Tanzania Demographic and Health Survey and Malaria Indicators Survey
Authors: Moshi Fabiola Vincent , Tungaraza Maximilian
Published: July 2020

Background: Hypertensive Disorder of Pregnancy (HDP) is one of the leading causes of maternal mortality and morbidity amongst pregnant women in the world. Blood pressure checkups during pregnancy are on of strategies to identify hypertensive disorders and hence timely management. Little is known on factors associated with blood pressure checkups in Tanzania.Method: The study used data from the 2015-16 Tanzania Demographic and Health Survey and Malaria Indicators Survey (2015-16 TDHS-MIS). A total of 6924women of active reproductive age from 15 to 49 were included in the analysis. Both univariate and multiple regression analyses were used to determine the association between early antenatal booking and maternal services utilization.Results: A total of 4997(72.17%) of interviewed women were checked for blood pressure at least once. After adjusted for the confounders, factors which influenced uptake of blood pressure checkups during pregnancy were timing for antenatal booking within first 12 weeks, AOR=1.496 at 95% CI= 1.297-1.726, p<0.001, age group [ more than 34 years, (AOR=1.518 at 95% CI=1.149-2.006,p=0.003)], wealth index [ middle income, (AOR=1.215 at 95% CI=1.053-1.468, p=0.008) and rich, (AOR=2.270 at 95% CI=1.907-2.702, p<0.001)] reference population being poor; education level [ primary education, (AOR=1.275 at 95%CI=1.107-1.468, p=0.001); secondary, (AOR=2.163 at 95% CI=1.688-2.774, p<0.001) and higher, (AOR= 9.929 at 95%CI=1.355-72.76, p=0.024)] reference population being no formal education; parity[para 2-4, (AOR=1.190 at 95% CI=1.003-1.412, p=0.046) and zones [Unguja Island, (AOR=3.934 at 95% CI=1.568-9.871, p=0.004) and Pemba Island, (AOR=5.308 at 95%CI=1.808-15.58, p=0.002)] Mainland urban being the reference populationConclusion: Blood pressure checkups during pregnancy offer the opportunity for early detection timely management of HDP. The study revealed that rural dwelling pregnant women had higher chance not to get their BP checked. It was also revealed that maternal age, education level, place of residence, wealth index and timing of ANC services significantly associated with blood pressure check-ups. The study identifies the need to explore significant factors associated with utilization of the available free reproductive health services across all public health facilities and to address prioritized intensive awareness programs and behavioral change interventions on the significance of BP checkups among pregnant women of reproductive age.
A Rational Framework for Development Iranian Twin Registry: Lessons Learned from Developed Twin Registries
Authors: Abtahi Hamidreza , Gholamzadeh Marsa , Shahmoradi Leila , Shariat Mamak , Zendehdel Kazem
Published: July 2020

Background: Regarding technology advancement in health sciences and the possibility of recording and organizing a huge amount of data, registries in various clinical domains have been established. The specific genetic structure of twins has enabled researchers to find answers to role of genetics and environment in medical sciences. Thus, twin registries were developed across the world to support twin studies. The main objective of this study is devising a conceptual model for developing the Iranian twin registry to ensure the success of this registry. Methods: In this descriptive and qualitative study, the combination of literature review, brainstorming, and focus group discussions were applied to develop a conceptual model of the twin registry. Based on our qualitative and thematic analysis, the workflow of information gathering and different data levels are described in this study. Results: According to the characteristics of established worldwide twin registries, the success factors in registry implementation were recognized. Moreover, based on our objectives, the hierarchical conceptual model of the registry was invented. The source of information, the different levels of data, and the information flow were determined based on this model. The workflow modeling of data gathering was represented through this survey to clarify the data collection and saving processes. Conclusion: Suggesting a conceptual model and standard framework for twin registry development at the national level based on the experiences of other countries could guide researchers in twin registries implementation efficiently. Moreover, the next steps of implementing a twin registry in a standardized and stepwise way are outlined in this project.
The Effect and Mechanism of ROS-Mediated Activation of NLRP3 Inflammasome in Hepatic Alveolar Echinococcosis
Authors: chen caisong , zhang yaogang , wang zhixing , wang haijiu , fan haining
Published: July 2020

Background: The NLRP3 inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic diseases. However, its role in hepatic alveolar echinococcosis (HAE) remains unclear. Therefore, we aimed to investigate the NLRP3 inflammasome and its activation mechanism in HAE.Method: We assessed the expression of NLRP3, Caspase-1, interleukin (IL)-1β, and IL-18 in the inflammatory marginal zone and corresponding normal liver tissues of 60 patients with HAE. We used a rat model of HAE to investigate the role of the NLRP3 inflammasome in the inflammatory marginal zone of HAE. Transwell experiments were conducted to investigate the effect of Echinococcus multilocularis in stimulating Kupffer cells and hepatocytes. Further, immunohistochemical staining, western blotting, and ELISA assessed the expression of NLRP3 and Caspase-1, IL-1β, and IL-18, and flow cytometry was used to detect apoptosis and ROS.Results: The activation of NLRP3 inflammasome was intimately associated with the expression of ROS(P<0.05). Inhibition of ROS generation decreased the activation of NLRP3-Caspase-1-IL-1β pathway and mitigated damage to hepatocytes (P <0.01) as well as inflammation (P <0.001) in HAEConclusion: E. multilocularis can induce hepatocytes damage and inflammatory response by activating the ROS-NLRP3-Caspase-1-IL-1β pathway in Kupffer cells, indicating that ROS may be a potential target for the treatment of HAE.
Clinical Benefit and Agenda for Clinical Sequencing Using Cancer Panel Testing: A Retrospective Clinical Study
Authors: Nishimura Sadaaki , Sugimoto Atsushi , Kushiyama Shuhei , Togano Shingo , Kuroda Kenji , Yamauchi Makoto , Sumi Toshiyuki , Kaneda Hiroyasu , Kawaguchi Tomoya , Kato Minoru , Kimura Kenjiro , Nagahara Hisashi , Lee Shigeru , Muguruma Kazuya , Takashima Tsutomu , Kubo Shoji , Ohira Masaichi , Yashiro Masakazu
Published: July 2020

Background: Clinical sequencing using a multiplex gene panel has recently been applied worldwide for patients with refractory solid tumors, but the significance of clinical sequencing using multiplex gene panel testing remains uncertain. Here we sought to clarify the feasibility and utility of clinical sequencing in the treatment of refractory tumors at our hospitalMethods: A total of 28 patients with advanced solid tumors treated at our hospital between 2018 and 2020 were enrolled in the clinical sequencing. Among them, we identified 26 patients whose tissue samples were of suitable quality for clinical sequencing, and we analyzed the genomic profiles of these tumors.Results: Pathogenic alterations were detected in 20 (77%) of the 26 patients. The most common mutation was TP53 (6/26, 35%), followed by KRAS (5/26, 19%), and the highest frequency of gene amplification was ERBB2 (5/26, 19%). Five of the 26 patients were identified as candidates for novel molecular-targeted therapy based on their actionable gene alterations, but none of the cases had an advantage for novel targeted therapy following the genetic tests; the reasons were clinical deterioration, refusal for off-label use, and complexity of clinical trial access.Conclusions: Our current results suggested that clinical sequencing might be useful for the detection of pathogenic alterations and the management of additional cancer treatment. Both improved optimal timing of clinical sequencing and a consensus about its off-label use might help patients receive greater benefit from clinical sequencing.Trial registration: This study was performed as a part of clinical study approved by Ethical Committee of Osaka City University Graduate School of Medicine (Permission number: 4199, 3925)
miR-181 Expression is Associated With The Prognosis in Lung Cancer.
Authors: Zhao Yue , Kong Xiangjun , Wang Hongbing
Published: July 2020

Background: Lung cancer is one of the most common cancers, with high morbidity and mortality. MiRNAs are proved to play important roles in various human cancers. In our study, we aimed to explore the prognostic value of miR-181 in lung cancerMethods: Quantitative real-time polymerase chain reaction (QRT-PCR) was used to detect the expression level of miR-181 in lung cancer tissues and the paired non-cancerous tissues. The relationship between miR-181 expression and clinicopathologic parameters were analyzed by chi-square test. Kaplan-Meier method with log rank test was applied for overall survival analysis. Furthermore, the Cox regression analyses were performed to evaluate the prognostic value of miR-181 in lung cancer.Results: Down-regulated miR-181 expression was observed in lung cancer tissues (P<0.001), moreover, its expression was significantly correlated with TNM stage (P=0.015) and metastasis (P=0.000). In addition, lung cancer patients with lower miR-181 expression level had poorer overall survival than those with higher expression (log rank test, P=0.011). Cox regression analysis suggested that miR-181 was an independent prognostic factor for lung cancer (HR=1.961, 95%CI=1.135-3.388, P=0.016).Conclusion: MiR-181 may be a tumor suppressor gene in lung cancer, which can predict outcomes for the patients.
Stability Analysis of Self Propelled Multi-Utility Platform for Orchard Management System using Point Manipulation Method
Authors: Roul Ajay Kumar , Bhargav Vinod Kumar
Published: July 2020

Self-propelled hydraulically operated multi-utility platform for orchard management system (SOMS) was developed to increase the accessibility of pickers to fruit on trees and to carry out orchard management practices like spraying and pruning. The platform was designed for vertical reach of 6 m and load carrying capacity of 200 kg. Point manipulation programme was developed by Microsoft Excel add in and by trial and error, position of the standard components were decided to determine the centre of gravity of the machine. Standard components were placed over the chassis in such an arrangement that, the centre of gravity (CG) always remain over the chassis during entire operation of the platform from minimum to maximum height with designed load. Forces acting on the chassis were analyzed to find out weight transfer and impending stability in various terrain conditions, various bucket positions loads on the bucket. The prediction equation for the determination of horizontal center of gravity (Xcg) was verified with the true value collected by keeping the wheels of SOMS on individual electronics weighing balance. The average absolute variations between the predicted and measured values of Xcg were within 0.44 % and 3.53%.
miR-765 Impairs Pancreatic β-cell Function by Targeting PDX1 in type 2 Diabetes
Authors: Zheng Li , Wang Yalan , Li Yanhong , Li Li , Wang Xiaohong , Li Yan
Published: July 2020

Background: Type 2 diabetes (T2D) is highly connected with the defect in insulin secretion of pancreatic β-cells, which has been developing into a severe public health problem.Methods: Here, we first detected expression of PDX1 and miR-765 in peripheral blood from 40 patients with T2D and 40 healthy volunteers. INS-1E cells (pancreatic β-cell line) were cultured as experimental model. For glucose induction, we incubated INS-1E cells with 11 mM glucose as control group and INS-1E cells with 25 mM glucose as T2D model group. For target relationship verification, we performed Luciferase reporter assay. Generally, we utilized qRT-PCR (quantitative real-time PCR), western blotting, insulin secretion detection, CCK-8, and flow cytometry in this study.Results: The expression level of PDX1 was dramatically lower in peripheral blood from T2D patients than healthy volunteers, while miR-765 exhibited an opposite result. PDX1 expression level had an inverse correlation with blood glucose level of T2D patients whereas miR-765 exhibited a positive correlation. Furthermore, PDX1 improved insulin secretion, cell viability, and restrained cell apoptosis of INS-1E cells. PDX1 was identified as a target of miR-765 which was observed to reduce insulin secretion, cell viability, and induce cell apoptosis of INS-1E cells.Conclusions: Taken together, we confirmed that miR-765 could cause detrimental effect on pancreatic β-cell survival and function by targeting and repressing PDX1 in T2D.
Influence Psycho-Sexual Factors on The Quality of Life in Pregnant Women During the COVID-19 pandemic: A Path Analysis
Authors: Alijanpour Masoumeh , Sadatmahalleh Shahideh Jahanian , Samaneh Youseflu , Mahnaz Bahri Khomami , Majid Yousefi Afrashteh , Moini Ashraf , Kazemnejad Anoshiravan
Published: July 2020

Background: Coronavirus has spread rapidly around the world. This epidemic has created stress and anxiety for pregnant women in different parts of the world. The aim of this study was to investigate the relationship between quality of life (QoL) with anxiety, depression, corona disease anxiety, sexual function (SF), and marital satisfaction (MS) in pregnant women during the Covid-19 pandemic.Methods: The present study is a cross-sectional study involving 260 pregnant women. The Short-Form Health Survey (SF_12), Marital Satisfaction Scale (MSS), Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS), and coronary disease anxiety questionnaire, Padua Obsession Questionnaire, General Health Questionnaire (GHQ) are used for data collection. Data were analyzed using the Pearson correlation coefficient and path analysis.Result: The overall goodness-of-fit statistics revealed that the predictors of QOL had perfectly good fitness indices (RMSEA=0.02; AGFI=0.99). The results show that corona related anxiety, marital satisfaction (MS), sexual function (SF), depression, and anxiety have a direct effect on women’s QOL. Among variables, GHQ has a more direct effect on women’s QOL. General health (GH) considered as a mediator variable; variables such as anxiety, depression, and Corona-related Anxiety with effect on GH can impress QOL. Anxiety as a main predictor of QOL, with direct, and indirect effects through GH, depression, SF, and MS can impress QOL. Conclusion: Since the QoL in pregnant women is associated with coronavirus epidemics, these results can be used to plan to improve the health and QoL of these people.
Implications of HBV-Driven Epigenetic Remodeling and Its Targets in Liver Cancer Stem Cells
Authors: Demir Ayse Banu , Benvenuto Domenico , Karacicek Bilge , Erac Yasemin , Angeletti Silvia , Ciccozzi Massimo , Tosun Metiner
Published: July 2020

Background: Elevated levels of STIM1, an endoplasmic reticulum Ca2+ sensor/buffering protein, appear to be correlated with poor cancer prognosis where microRNAs are also known to be involved. We investigated a possible viral origin of specific microRNAs identified in Huh-7 human liver cancer stem cells with enhanced STIM1 expression. Methods: Computational strategies including phylogenetic analyses were performed on miRNome data obtained from Huh-7 liver cancer stem cells with enhanced STIM1 and/or Orai1 expression originally cultured in the present study. Results: Results revealed two putative regions in HBV genome based on apparent clustering pattern of stem loop sequences of microRNAs, including miR3653. Reciprocal analysis of these regions revealed critical human genes of which their transcripts are among the predicted targets of miR3653 which was increased significantly by STIM1 enhancement. Conclusion: This study presents a phylogenetic evidence for an HBV-driven epigenetic remodeling to alter gene expression pattern associated with Ca2+ homeostasis in STIM1-overexpressing liver cancer stem cells for a possible mutual survival outcome. A novel region on HBV-X protein may affect liver carcinogenesis in a genotype-dependent manner. Therefore, detection of the HBV genotype would have a clinical impact on prognosis.
Variation in COVID-19 among Eastern Mediterranean Region countries: A comparative study
Authors: Albelbeisi Ahmed Hassan , Albelbeisi Ali , Bilbeisi Abdel Hamid El , Afifi Amany El , Taleb Mahmoud
Published: July 2020

Objective: Coronavirus disease 2019 (COVID-19) is spreads in 216 countries and territories among the world including all Eastern Mediterranean Region countries. The aim of the present study was to examine variation of COVID-19 in different income class countries of the Eastern Mediterranean Region. Methods: Five parameters such as the percentage of variation COVID-19 confirmed cases, the percentage of variation number of deaths, death rate per 1000 confirmed cases, the percentage of variation death rate per 1000 confirmed cases, and tests per one million were calculated. Results: The results demonstrated that all Eastern Mediterranean Region countries increase in percentage of COVID-19 confirmed cases except Tunisia, the increasing range from 53.5% in Libya to 4.7% in Morocco. Death rate per 1000 confirmed cases range from 230.1 in Yemen to 0.92 in Qatar. Majority of countries increase in percentage of COVID-19 deaths cases number, which range from 43.7% in Iraq to 1.4% in Morocco. Fourteen countries decrease in percentage of death rate per 1000, the decreasing range from 34.9% in Libya to 0.09 in Yemen. The tests per one million range from 265687 in United Arab Emirate to four in Yemen. Conclusion: The current study findings showed significant variations between the Eastern Mediterranean Region countries, the substantial variation is concerning. The low-income countries appeared more vulnerable compared to high-income countries; the low-income countries should not be alone with this pandemic. Hence then global should be helping these countries and particular plans have to be employed. These must include screening tests COVID-19 virus.
Identification of Iron Metabolism-Related Genes Signature and Novel Role of FLVCR1 in Hepatocellular Carcinoma
Authors: Chen Jianhui , HU Chuan , Pan Reguang , Du Xuedan , Fu Haotian , Shan Yunfeng
Published: July 2020

Background: Hepatocellular carcinoma (HCC) is the main and highly malignant histological subtype of liver cancer. We tried to construct a novel signature with iron metabolism-related genes to provide new therapeutic targets and improve the prognosis for HCC patients.Methods: The gene expression data of 70 iron metabolism-related genes and its relevant clinical information were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Consensus clustering analysis was performed to determine clusters of HCC patients with different OS. Cox regression and LASSO regression analyses were used to establish a prognostic signature. Receiver operating characteristic (ROC) and Kaplan–Meier analyses were carried out to examine the predicated performance of the signature.Results: Consensus clustering analysis determined two clusters of HCC patients with different OS(p<0.01), TNM stage(p<0.05) and pathological grade(p<0.05). A nine-gene prognostic signature established with iron metabolism-related genes can independently predicate the prognostic of HCC patients. The ROC curves showed a great performance of the signature. In addition, FLVCR1, a hub gene with the highest mutation frequency in our signature, showed the significantly prognostic value in HCC patients. High FLVCR1 expression was significantly associated with poor prognosis and aggressive progression in HCC patients. The promoter methylation level of FLVCR1 was lower in HCC samples with aggressive progression status. The FLVCR1 expression was positively correlated with the infiltration level of B cell, CD4+ T cell, macrophage, neutrophil and dendritic cell. Conclusion: Our study first established a signature related to iron metabolism and identified FLVCR1 as a potential therapeutic target. These findings provided more treatment strategies for HCC patients.
Wilms’ Tumor 1-Associating Protein Promotes Prostate Cancer Proliferation via Upregulation of CDK4 Transcript
Authors: Zhang Lei , Gao Yiren , Wang Jun , Liang Linghui , Cheng Yifei , Qi Feng , Wang Zengjun , Hua Lixin , Cheng Gong
Published: July 2020

Background: Wilms’ tumor 1-associating protein (WTAP) plays an important role in cell physiological function and have attracted increased interest in cancer research recently. Cyclin-dependent protein kinases (CDKs) are known to participate in regulating the cell cycle and often connected to many malignancies in tumor. We aim to explore whether WTAP or CDKs could play an role in the initiation and progression of prostate cancer(PCa) and hope to provide new insights into PCa treatment and prognostic. Methods: Quantitative real-time PCR, western blotting and immunohistochemistry were performed to explore the expression of WTAP and CDK4 in prostate cancer tissues and cell lines. The survival analysis was used to investigate the association between WTAP expression and the clinical outcomes of prostate cancer. Prostate cancer cell lines were stably transfected with lentivirus approach. CCK-8 assay, colony formation assay, cell invasion and migration assay, cell cycle assay and tumorigenesis in nude mice were performed to study the effect of WTAP in prostate cancer cell lines. RNA immunoprecipitation assay, dual-luciferase reporter assay and siRNA transfection were performed to verify the direct binding sites of WTAP with CDK4 transcript.Results: In prostate cancer tissues and cell lines, WTAP was significantly up-regulated and high expression of WTAP was connected to poor clinical outcomes. Additionally, cell function test indicated that overexpression of WTAP in prostate cancer cell lines could promote cell proliferation, while knocking down showed an opposite results. Subcutaneous xenograft tumor model revealed that overexpression of WTAP could induce tumorigenesis in vivo. Mechanism study showed that CDK4 expression could regulate the expression level of WTAP. Moreover, WTAP could directly bind to 3’-UTR of CDK4 transcript and enhance its stability. Furthermore, specific inhibitors of CDK4 as well as small interfering RNA (siRNA) of CDK4 reversed the promotion of proliferation induced by WTAP.Conclusions: These data indicated that WTAP may act as an oncogenic in prostate cancer by directly binding to CDK4 3’-UTR and stabilizing its transcript which might provide new insights into prostate cancer treatment and prognostic.
Condições micrometeorológicas entre uma área de floresta e a campo
Authors: Salvador Bruna Matos , Minuzzi Rosandro Boligon
Published: July 2020

O objetivo deste trabalho foi comparar a variação da temperatura do ar, umidade relativa do ar (UR) e temperatura no ponto de orvalho (Td) durante o inverno e verão, em diferentes escalas temporais (diário, diurno e noturno), numa área de floresta e a campo, no município de Águas Mornas, em Santa Catarina. A correlação das variáveis entre os ambientes foi analisada com o uso da regressão linear, onde considerou-se os dados obtidos a campo como a variável independe X e as obtidas na floresta como variável dependente Y. A significância estatística das regressões foi testada com o uso do valor-p. As diferenças entre as médias e variâncias dos dados entre os ambientes, épocas do ano e escala temporal, foram testadas ao nível de 5% de significância usando os testes t de Student e F de Snedecor, respectivamente. Todas as análises estatísticas foram realizadas com o uso do software Past 3.0. Observou-se diferença entre os dois ambientes da temperatura média e máxima do ar e umidade relativa do durante o verão. A temperatura do ar e do ponto de orvalho entre os ambientes apresentaram as maiores correlações. Assim, pode-se estimar estes elementos climáticos para floresta, a partir de dados obtidos a campo.
FITOSSOCIOLOGIA DE PLANTAS DANINHAS EM CULTIVO DE AÇAIZEIRO
Authors: Almeida Ueliton Oliveira de , Andrade Neto Romeu de Carvalho , Marinho José Tadeu de Souza , Gomes Romário Rodrigues , Oliveira João Ricardo de , Santos Rayane Silva dos , Teixeira Júnior Davair Lopes , Araújo Jamayra Conceição de
Published: July 2020

As plantas daninhas são consideradas como um dos principais problemas nas culturas, pois interfere no rendimento, qualidade do produto e na rentabilidade da atividade agrícola. O adequado manejo destas plantas depende, primeiramente, da identificação das espécies presentes na área. O levantamento fitossociológico é uma importante ferramenta para auxiliar na escolha do melhor método de controle e quando realizá-lo. Objetivou-se com este estudo foi realizar levantamento fitossociológico de plantas daninhas em monocultivo de açaizeiro solteiro no município de Rio Branco, Acre. O estudo foi realizado no campo experimental da Embrapa Acre em março de 2014. As amostragens foram realizadas com um quadrado de madeira de 0,25 m2 (0,50 x 0,50 m), o qual foi lançado ao acaso por doze vezes em toda a área. As plantas daninhas foram quantificadas e identificadas quanto à classe, família, espécie, nome comum, tipo de propagação, hábito de crescimento e o respectivo ciclo de vida, além dos seguintes parâmetros fitossociológicos: densidade absoluta (D), densidade relativa (DR%), abundância absoluta (A), abundância relativa (AR%), frequência absoluta (F), frequência relativa (FR%), importância relativa (IR%) e o índice de valor de importância (IVI). Identificou-se 34 espécies distribuídas em 13 famílias, destacando-se as famílias Poaceae, Cyperaceae e Asteraceae, com 11, 6 e 3 espécies, respectivamente. A classe das dicotiledôneas apresentou o maior número de famílias (76,92%) enquanto que a das monocotiledôneas representou a maior quantidade das espécies (55,88%). A maioria das espécies observadas propagam-se por sementes, apresentam hábito de crescimento herbáceo e ciclo de vida anual. As espécies mais importantes foram Digitaria sanguinalis e Mollugo verticillata, pois se destacaram em todos os parâmetros fitossociológicos analisados.
AVALIAÇÃO DA SUSTENTABILIDADE AMBIENTAL A PARTIR DO BALANÇO DE NUTRIENTES EM UMA PROPRIEDADE DO OESTE CATARINENSE
Authors: Schneider Graciela , Mattias Jorge Luis , Berto James Luiz , Sartori Leno
Published: July 2020

O descarte de dejetos animais em sistemas de culturas e pastagens tem sido uma das opções mais viáveis ambientalmente e economicamente para destinar esse tipo de resíduo, porém deve-se atentar para que os mesmos sejam aplicados em quantidades proporcionais à demanda de nutrientes pelas plantas. Objetivou-se, nesse estudo, avaliar a sustentabilidade ambiental de uma propriedade rural do oeste catarinense com concentração de aves de corte e bovinos utilizando-se o balanço de massa de nitrogênio e fósforo. Os teores de nutrientes dos insumos e produtos foram obtidos de dados médios da literatura e quando possível aplicado dados dos próprios produtos. A análise de um único ciclo de produção agrícola (julho/2016 a junho/2017) pode não ter apresentado resultados médios dos ciclos, já que a cama aviária não foi utilizada durante esse período, ocorrendo um incremento considerável de adubos externos. Analisando-se o sistema sem a inserção dos adubos externos, verifica-se um excedente de nutrientes que não são reaproveitados como fertilizantes, o que apontaria, em longo prazo, para a insustentabilidade ambiental da propriedade, devendo ser adotadas medidas na busca do equilíbrio no balanço desses nutrientes.
Normal modes in thermal AdS via the Selberg zeta function
Authors: Martin Victoria , Svesko Andrew
Published: July 2020

The heat kernel and quasinormal mode methods of computing 1-loop
partition functions of spin ss
fields on hyperbolic quotient spacetimes \mathbb{H}^{3}/\mathbb{Z}ℍ3/ℤ
are related via the Selberg zeta function. We extend that analysis to
thermal \text{AdS}_{2n+1}AdS2n+1
backgrounds, with quotient structure \mathbb{H}^{2n+1}/\mathbb{Z}ℍ2n+1/ℤ.
Specifically, we demonstrate the zeros of the Selberg function encode
the normal mode frequencies of spin fields upon removal of
non-square-integrable modes. With this information we construct the
1-loop partition functions for symmetric transverse traceless tensors in
terms of the Selberg zeta function and find exact agreement with the
heat kernel method.
ROBERT LEVIN’İN MOZART YORUMCULUĞU BULGULARININ UYGULAMA PRENSİPLERİ
Authors: ÜNALDI Osman Özgür
Published: July 2020

﻿Avusturyalı klasik dönem bestecisi Wolfgang Amadeus Mozart hakkında yapılan araştırmalar piyanist ve müzikolog Robert Levin’in öncülüğünde hızlanarak gelişme kaydetmiş, bulgular müzisyenler ve müzikologlar arasında yayılmaya başlamıştır. Mozart’ın beste yapma ve eser yorumlama davranışlarını detaylarıyla inceleyen Levin, sadece Mozart değil, klasik dönem hatta genel olarak yorumculuk anlayışını değiştirebilecek güçte bulgular elde etmiştir. Bu bulgular ışığında Levin, bir bütün olarak yorumculuk disiplinine, sanatına ve bilimine büyük katkılar sağlamıştır. Ancak yapılan kayıtlar, gerçekleşen konserler ve yarışmalardan anlaşılmaktadır ki, geçtiğimiz yüzyılın yorumculuk alışkanlıkları bugün bu bulgulara hala direnmektedir. İşte bu çalışmanın amacı, bilgilerin uygulanabilmesine katkıda bulunarak bu direnci ortadan kaldırmak, Mozart yorumu konusundaki temel sorun ve yeni bulguların en zorlayıcı taraflarından biri olan doğaçlama konusunu inceleyip yöntemler geliştirerek hem yorumcuya hem de yorumcu adayı öğrencilere yol göstermektir.
LEVANTAMENTO DE ESPÉCIES VEGETAIS COMERCIALIZADAS NO MERCADO DOS COLONOS “MIGUEL MARCELINO DE SOUZA”, XAPURI - ACRE
Authors: Pinheiro Jennifer Maria Rodrigues , Fernandes Alana Chocorosqui
Published: July 2020

A feira livre representa uma das formas mais antigas de comercialização de produtos agrícolas, viabilizando a comercialização direta entre consumidores e produtores. Sabendo disso, o objetivo deste trabalho foi realizar levantamento de espécies vegetais comercializadas no Mercado dos Colonos “Miguel Marcelino de Souza”, Xapuri, Acre. Para isso foi realizada visita inicial para conhecer o estabelecimento e posterior aplicação de entrevistas semi-estruturadas a 10% dos feirantes. As entrevistas foram aplicadas no mês de Agosto de 2017, especificamente nas quintas e sextas-feiras, entre 06h30min e 09h00min, com duração média de 15 minutos cada, sendo executadas diretamente nas bancas. Os dados foram tabulados e analisados por meio do programa Microsoft Excel 2010, utilizando o acompanhamento de documentação fotográfica. O levantamento realizado demonstrou a importância de frutas, mamão e banana; e de hortaliças; couve, a cebolinha e coentro na região. A mandioca teve destaque sendo fonte de vários produtos processados, que aumentam o valor agregado do produto e contribui para uma melhor renda dos vendedores. Houve variação no preço, forma de comercialização, origem dos produtos e forma de embalagens. Dos entrevistados, 93% são produtores rurais. O Mercado Miguel Marcelino de Souza se torna importante regional e localmente, pois oferta ampla variedade de produtos a comunidade de Xapuri e arredores, sendo espaço de oportunidade para famílias comercializarem sua produção.
DIÁLOGO DE SABERES A PARTIR DA COMUNIDADE TRADICIONAL CAIÇARA DO GUARAGUAÇÚ, PONTAL DO PARANÁ/PR
Authors: Borges da Silva Daniele , Haliski Antonio Marcio
Published: July 2020

Estudos sobre comunidades tradicionais estão em evidência na América Latina, assim, apresentaremos como se deu a formação docaiçara, no litoral paranaense, especificamente na comunidade do Guaraguaçú, localizada no município de Pontal do Paraná/Pr. Uma das características dos moradores desta comunidade são os saberes tradicionais, transmitidos de geração em geração, tais saberes relacionam-se ao manuseio de plantas medicinais, da agricultura, culinária, artesanato, entre outros. Metodologicamente, objetivamos analisar esses saberes e relacionar os tipos de conhecimentos tradicionais com o conhecimento científico, a partir de uma ótica da CTS (Ciência, Tecnologia e Sociedade), tendo como embasamento teórico pensadores da Escola de Edimburgo, como David Bloor, a partir do pressuposto de que o conhecimento se refere às crenças que as pessoas sustentam com confiança e com as quais regem a vida. Com Antonio C. Diegues abordaremos a formação da identidade caiçara, para entendermos a formação da comunidade.Com objetivo de compreender esses saberes silenciados, do ponto de vista dos atores e atrizes sociais, utilizaremos trabalhos acadêmicos, produzidos, em geral, pelos próprios moradores da comunidade.A antropóloga Manuela Carneiro da Cunha (2009), aborda as relações e dissenções entre saberes tradicionais e saber científico. Deste modo, objetivamos evidenciar o saber tradicional caiçara não como dicotômico do conhecimento científico, mas como uma possibilidade de saber e racionalizar a realidade.
A TEORIA ATOR REDE COMO MÉTODO PARA ABORDAGEM SOURCE TO SEA
Authors: Cunha Ellen Joana Nunes Santos , Krelling Allan Paul
Published: July 2020

O objetivo dessa pesquisa é demonstrar por meio da Teoria Ator Rede os actantes envolvidos na abordagem Source to sea e o mapa de ligações entre os ecossistemas naturais e a proposta Source to sea. O método utilizado foi a Teoria Ator Rede de Bruno Latour, por meio da aplicação de associações rastreáveis para a composição da rede. O estudo permitiu perceber que a abordagem Source to sea possui conexões e interconexões como alianças, fluxos e mediações nas dimensões sociais e ambientais, permitindo a visualização de uma rede. A abordagem Source to sea, preenche uma possível ausência de soluções no entendimento entre os actantes, que tem por base compreender a cooperação transfronteiriça da água e suas possíveis pressões. Conclui-se que a promoção de ações transfronteiriças e locais via abordagem source to sea de gestão para o devido saneamento dos cursos naturais da água, destacam uma grande rede de fluxos nos principais ecossistemas do planeta.
The Synthesis of New Selenium-containing Heterocycles by the Oxidation Reaction of 2,4-Diaryltetrahydro-4H-selenochromenes
Authors: Direnko Dmitriy Yurievich , Drevko Boris Ivanovich , Drevko Yaroslav Borisovich
Published: July 2020

We have explored the reactions of tetrahydro-4H-selenochromenes in the presence
of phosphoric pentachloride, and synthesized new condensate aroylbenzoselenophenes.
During the reactions, tetrahydro-4H-selenochromenes with phosphoric pentachloride underwent
oxidative aromatization and nucleophilic substitution for a chlorine atom of one of
the protons in the alicyclic fragment. Also, the narrowing of the heterocyclic fragment occurred
as in synthesized selenium-containing compounds earlier transformed into the corresponding
condensate aroylbenzoselenophenes.
Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients
Authors: Guzelcicek Ahmet , Gönel Ataman , Koyuncu Ismail , Cigdem Gulyara , Kose Dogan , Karadag Mehmet , Cadirci Dursun
Published: July 2020

Background:

Hydrocephalus, a common brain disorder in children, can cause
permanent brain damage. A timely diagnosis of this disorder is crucial.

Objective:

The aim of this study was to evaluate the levels of S-100, CK-18, and NSE brainspecific
proteins in patients with hydrocephalus. We examined the levels of these proteins in the
blood samples of hydrocephalic patients.

Methods:

The study was conducted on the hydrocephalus (n = 31) patients and a healthy control
group (n = 30). A Receiver Operating Characteristic (ROC) curve was used to assess the validity of
the NSE, CK-18, and S100B to differentiate between the hydrocephalus and the control groups.
The suitability of the data to the normal distribution was tested with the Shapiro Wilk test, and the
Student t-test was used to compare the characteristics of the normal distribution in two independent
groups. The individuals in the hydrocephalus and control groups had similar values in terms of age,
height, and weight.

Results:

It was observed that NSE, CK-18, and S100B mean values of the individuals in the
hydrocephalus group were significantly higher than NSE, CK-18, and S100B mean values of the
control group.

Conclusion:

Experiments have shown that the levels of these proteins increase significantly in
hydrocephalus patients compared to the healthy group. These three parameters can be considered
as important markers in the diagnosis of hydrocephalus.
Positive Role of Synthesis Method and Hard Template on the Catalytic Performance of SAPO-34 in Methanol to Olefin Reaction
Authors: Rimaz Sajjad , Katal Reza
Published: July 2020

In the present study, SAPO-34 particles were synthesized using hydrothermal (HT) and
dry gel (DG) conversion methods in the presence of diethyl amine (DEA) as an organic structure
directing agent (SDA). Carbon nanotubes (CNT) were used as a hard template in the synthesis
procedure to introduce transport pores into the structures of the synthesized samples. The
synthesized samples were characterized with different methods to reveal the effects of synthesis
method and using hard template on their structure and catalytic performance in methanol to olefin
reaction (MTO). DG conversion method results in smaller particle size in comparison with
hydrothermal method, resulting in enhancing catalytic performance. On the other side, using CNT
in the synthesis procedure with DG method results in more reduction in particle size and formation
of hierarchical structure, which drastically improves catalytic performance.
The Effect of Vitamin C Supplementation on Cardiac Enzymes After Coronary Artery Bypass Graft: A Double-blind Randomized Control Trial
Authors: Moludi Jalal , Alizadeh Mohammad , Chehri Godarz , Jafari-Vayghyan Hamed , Foroumandi Elaheh , Maleki Vahid , Ebrahimi Behzad , Sadeghpour Anita , Alizadehasl Azin , Tabaee Ali S.
Published: July 2020

Background:

Coronary artery bypass graft (CABG) is associated with oxidative stress and tissue damage. Vitamin C, as an antioxidant agent, has an important role in attenuating the oxidative stress damage and might have cardio-protective effects after CABG. We aimed to evaluate the probable roles of vitamin C supplementation in cardiac biomarkers after CABG.

Methods::

In this randomized control trial, 122 patients undergoing CABG were randomly assigned to the intervention (n=54) and control group (n=68) and received vitamin C (2 g intravenously) or placebo, respectively. The surgical methods of the patients in the two groups were identical. The primary efficacy endpoint of this trial is the difference in the levels of CK-MB, Troponin and Total Antioxidant Capacity (TAC) were measured at study entry and 24 hrs after surgery between the two groups.

Results::

The two groups were not significantly different in terms of basic variables. Within-group comparison showed significant rises in the level of troponin (P < 0.001) and CK-MB (P < 0.001) over time. However, between-group comparison showed no significant difference between the two groups in terms of CK-MB (P=0.826) and troponin (P=0.821). As a whole, the correlation between cardiac enzymes and surgical characteristic was not seen.

Conclusion::

The results showed that pretreatment with vitamin C could not reduce cardiac marker following CABG. After the intervention, TAC did not differ between and within the intervention and the control groups. Pretreatment with vitamin C as an antioxidant agent could not reduce ischemicreperfusion resulting in CABG.
First Autochthonous case of Emerged Zoonotic Cutaneous Leishmaniasis in Mazandaran Province, Northern Iran: kDNA-PCR Evidence Base
Authors: Niksolat Fatemeh , Tabaripour Rabeeh , Davoodi Lotfollah , Fakhar Mahdi
Published: July 2020

Background:

In the last decade, several cases of cutaneous leishmaniasis (CL) have
been recorded by the provincial health center of Mazandaran Province, northern Iran. However,
there is no documented report of autochthonous CL in the province yet.

Case Presentation:

The patient, a 59-year-old female, known case of diabetes mellitus, lived in
therural area of Kiasar district (in theeastern part of the Mazandaran) with 5 skin lesions suspected
of having vasculitis, without ahistory of traveling to the endemic areas of CL,was admitted to
Imam Khomeini teaching hospital, Sari. To rule out CL, fine needle aspiration(FNA)procedure was
used aseptically for the patient. Laboratory investigations showed Leishman bodies (amastigotes)
by direct smear preparation, and species identification confirmed Leishmania major (L. major) by
polymerase chain reaction (PCR)molecular method. Accordingly, this is the first documented report
of autochthonous CL in Mazandaran Province.

Conclusion:

Overall, due to the abundance of probable rodent reservoir hosts and confirmation of
infectionof sandflies (Phlebotomus papatasi) withL. major in the Kiasar district, where our patient
was livingthere, it seems that CL emerged in the eastern part of the province. Therefore, further
studies on rodents and sandflies fauna in terms of emerging leishmanial infection in the area is recommended.
Redox Reaction between an Oxo-Bridged Diiron Complex and Hydrazine: A Kinetic Study
Authors: Chandrabanshi Sarvjeet Kumar , Mukherjee Ritam
Published: July 2020

Objective:

Mechanistic investigation of the reaction between the complex ion
[FeIII
2(μ-O)(phen)4(H2O)2]4+ (1) (phen = 1,10-phenanthroline) and its hydrolytic derivatives
[FeIII
2(μ-O)(phen)4(H2O)(OH)]3+ (1a) and [FeIII
2(μ-O)(phen)4(OH)2]2+ (1b) which coexist in
rapid equilibria in the range pH = 3.00 to pH = 5.00 (pKa1 = 3.71 ± 0.03, pKa2 = 5.28 ±
0.07) with N2H5
+ ion to produce [Fe(phen)3]2+ has been covered in this study.

Methods:

Rise in absorbance of the product with time was measured and rates have been
determined using initial rate methods. Dependence of rate on pH and concentration of
N2H5
+ are studied in detail.

Results:

In the presence of excess phenanthroline, the reaction follows simple first-order
exponential profile. Interestingly, in the absence of any added phenanthroline, the reaction
becomes faster and the reaction profile changes to nearly linear with curvature near the end
of the reaction. Slight autocatalytic nature has been observed only for the slower reactions.
The observed rate constants obtained using initial rate method show first-order dependence
on the concentration of N2H5
+. An increase in rate with increasing pH has been noticed.
The plot of rate versus 1/[H+] shows saturation beginning near pH 4.6, suggesting that the
mono-deprotonated form of the complex (i.e. 1a) is the active oxidant in this pH range.

Conclusion:

Presumably, the reaction becomes faster in the absence of added
phenanthroline because ligand dissociation from the parent complex becomes facilitated
when there is no external phenanthroline ligand present. This produces a coordinatively
unsaturated Fe(III) species which is a faster oxidant.
Preparation and Characterization of scFv-Coupled Immunoaffinity Column for Purification of Fibrinolytic Enzyme from Bacillus subtilis Natto-89
Authors: Choe SunIl , Kim CholJin , Yun UnHui , Li HyonGwang , Kim CholHo
Published: July 2020

Background:

The focus of this study was to prepare and characterize the single-chain variable
fragment antibody (scFv)-coupled immunoaffinity column for purification of subtilisin BRC.

Methods:

The scFv against subtilisin BRC was immobilized onto CNBr-activated Sepharose 4B. Adsorption
isotherm for subtilisin BRC on scFv-BRC-coupled Sepharose 4B was obtained and calculated
the maximum binding capacity. The extraction conditions, including eluting solution, the concentration
of eluting solution and flow rate, were optimized. Under the optimized eluting conditions, the dynamic
binding capacity of the immunoaffinity column was determined.

Results:

The scFv-BRC-coupled Sepharose 4B for immunoaffinity purification of subtilisin BRC was
prepared. The coupling efficiency was about 78.4%, e.g. about 8 mg of scFv-BRC was covalently coupled
to 1 g CNBr-activated Sepharose 4B. The maximum equilibrium binding capacity (qm) and dissociation
constant (Kd) of the immunoaffinity column for subtilisin BRC were 3.01 mg/mL and 0.465
mg/mL, respectively. The immunoaffinity chromatography conditions were optimized and the subtilisin
BRC was purified 3.29-fold with 55.6%.

Conclusion:

The subtilisin BRC was effectively purified with high purity using scFv-BRC-coupled
Sepharose 4B and the dynamic binding capacity of the column was determined. These results suggested
that scFv-BRC can be used as a ligand for affinity purification of subtilisin BRC.
Eva Schürmann: Vorstellen und Darstellen
Authors: Eisele Theresa
Published: July 2020

Rezension zu

Eva Schürmann: Vorstellen und Darstellen. Szenen einer medienanthropologischen Theorie des Geistes. Paderborn: Wilhelm Fink 2019. 293 Seiten.
A diagnosis of students' errors in answering the mathematics test in senior high school
Authors: Shantika Evana Gina , Istiyono Edi
Published: July 2020

This study aims to reveal: (1) the characteristics of diagnostic test items used in mathematics subject of the first grade of senior high school (SHS); (2) the degree of errors from several types of students’ errors in answering mathematics test; and (3) the dominant factor causing the students to make mistakes in answering mathematics test. This study used a quantitative approach involving the first graders of eight SHSs in Mataram as the population. The sample was collected by a proportionate random sampling technique, consisting of 350 students for preliminary field testing and 450 students for main field testing. The research instrument was a mathematics diagnostic test, questionnaire, and interview guidelines. The results show that: (1) the diagnostic test instrument meets the qualitative and quantitative content validity, proves empirically fit with Partial Credit Model (PCM), has reliability index of 0.92 (high category), and all items in the diagnostic test instrument are categorized in moderate difficulty; (2) misrepresentation becomes dominant errors if compared with misconceptions, the counting errors, and procedural errors. The errors dominant in the topic domain are Inequalities Linear System Two Variables if compared with Rational and Irrational Inequality One Variable, Equations and Inequalities of Absolute Value, and Linear Equations System Three Variables; and (3) most of the students do not understand how to solve the problem of inequality, determining factor quadratic equations, determining the members of the set completion, problems concerning graphs, and problems that require the capability of language interpretation into the mathematics model.
Estimation of college students’ ability on real analysis course using Rasch model
Authors: Isnani Isnani , Utami Wikan Budi , Susongko Purwo , Lestiani Herani Tri
Published: July 2020

This study is aimed at estimating the difficulty level of essay tests and the accuracy of students’ ability in Real Analysis essay test using the Rasch model with the QUEST program and R 3.0.3 package eRm program. The population in this study was all students of the Department of Mathematics Education, Universitas Pancasakti Tegal in the academic year 2016/2017, who were enrolled in the Real Analysis course. The data were analyzed using the R 3.0.3 package eRm program and QUEST program. The students’ ability was obtained from the result of the course final exam of the first Real Analysis course. The analysis shows that: (1) by using Rasch model for partial credit scoring, the difficulty level shows that 100% of essay questions in Real Analysis final exam is categorized as difficult, (2) the estimation of students’ ability in Real Analysis course using Rasch Model with CML method is better than the estimation of students’ ability using Rasch Model with JML approach.