bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengthening Capabilities of Local Government Institutions in Disaster Management : A Study of Flood-prone Areas in Alappuzha District, Kerala
Authors: Sreeja K. , Gireesan K.
Published: September 2024

This research paper focuses on disaster management activities carried out by Panchayati Raj institutions (PRIs) in India, specifically emphasising disaster preparedness at the local level. Given India’s vulnerability to natural disasters, this paper underscores the need for proactive approaches and citizen-centric as well as participatory strategies in disaster management. It draws on in-depth fieldwork conducted in four highly vulnerable and disaster-prone Gram Panchayats in Alappuzha district, Kerala. The study reiterates the importance of empowering PRIs, as they are the most significant political institutions to engage in the pre-disaster phase, and it emphasises the need to strengthen the capabilities of PRIs in disaster management, with a focus on disaster preparedness. Additionally, this paper explores the application of the principle of subsidiarity in disaster management, focusing on the delegation of tasks by mapping responsibilities to Gram Panchayats (GP), Block Panchayats (BP), and District Panchayats (DP).
Job-Home Balance of Rural Women Employees: An Insight Study from Bangalore Rural District
Authors: Karlapudi Thriveni
Published: September 2024

The present dynamic organisational environment has presented numerous challenges for women employees, with maintaining a harmonious balance between their professional and domestic responsibilities emerging as a particularly salient concern. This study examines the key determinants that influence the job-home balance of female employees in the Bangalore Rural district. The study surveyed 360 female employees working across various service and manufacturing industries. The data was collected through a structured questionnaire and analysed using factor analysis, correlation, and multiple regression techniques with SPSS 21.0. The findings indicate that a range of factors, including demographics, stress, interpersonal relations at home, job characteristics, emotional well-being, and work circumstances, significantly and strongly influence job-home balance. A better job-home balance has been found to increase organisational productivity, job satisfaction, and employee engagement while decreasing absenteeism and attrition.
Assessing the Compliance of the Local Self-Governance Act for PESA in Jharkhand: A Policy Review After Two-and-a-Half Decades of its Inception
Authors: Kindo Dipti Paridhi , Bhowmick Pradip Kumar
Published: September 2024

The ‘Panchayat Extension to the Scheduled Areas (PESA) Act, 1996’ has completed twenty-six years since its inception. Despite this, it remained dissonant in four out of 10 PESA states before 2022, affecting nearly half of the population residing in the Fifth Schedule Areas (FSA), which are predominantly inhabited by indigenous and tribal peoples with their customary laws, social norms, and traditional practices of common resources. Two states, Chhattisgarh and Madhya Pradesh, implemented the state-specific PESA Guidelines in 2022, but Jharkhand and Odisha have yet to do so. This paper analyses the status of compliance with all the 13 provisions of the PESA Act under the ‘5-E approach’ model with main sections as Effectiveness, Efficiency, Ethical Considerations, Manageability or Evaluation of Alternatives and Establishment of Recommendations for positive change in a tribal-dominated Jharkhand, where 16 out of 24 districts come under the provisions of PESA comprising 32 distinct schedule tribes. The paper indicates that the morally acceptable separate PESA Rules have to be framed with the resolution to be passed in Jharkhand, which will confer a right-based approach to authority and powers essential for the indigenous and tribal people to act as an institution of self-government. Moreover, Sustainable Development Goal Target 16.7 aims to ensure responsive, inclusive, participatory, and representative decision-making at all levels, and PESA can act as a means to ensure it.
Avaliação da motivação e da empatia dos estudantes no atendimento presencial e nas teleconsultas em um curso de Medicina
Authors: Oliveira Camila Bernardes Mendes de , Peixoto José Maria , Cardoso-Júnior Aloísio
Published: September 2024

Objetivo: Avaliar a motivação e a empatia manifestadas por estudantes de Medicina no AP e no TC. Métodos: Alunos do 8° período (n=63) alocados pelo curso para a realização de AP (n=35) e TC (n=28), foram selecionados em amostragem por conveniência. Para a avaliação da empatia foi utilizada a escala de Jefferson (JSPE-vs), aplicada na 3ª e na 13ª semana de atendimento. A motivação foi mensurada por meio da aplicação do questionário Instructional Materials Motivation Survey (IMMS-BRV) na 13ª semana de atendimento. Resultados: A motivação foi elevada em ambos os grupos, em todas as dimensões. O escore global da empatia demonstrou que, antes da exposição ao AP e às TC, os grupos eram iguais. Após a exposição o grupo AP apresentou resultados significativamente superiores. Conclusão: O AP esteve associado ao maior desenvolvimento da empatia, ambas formas de atendimento foram motivadoras e o aumento da motivação esteve associado ao aumento da empatia dos estudantes no atendimento clínico.
Narrative analysis of the biblical text in the context of traditional Orthodox exegesis Priest Dionisy Kim
Authors: Ким Д.
Published: September 2024

В статье рассматривается нарративный метод в библеистике в контексте использования этого подхода в современной гуманитаристике и святоотеческой экзегезе. Указывается, что отечественная библеистика плохо знакома с зарубежной нарративной критикой. В то же время автор подчеркивает актуальность освоения нарративного метода русской церковной наукой. В статье дается характеристика нарративного метода в современной гуманитаристике; показаны истоки нарративной критики Библии. Автор систематизировал главные методологические принципы нарративного анализа применительно к библейскому тексту. Главной частью публикации является сравнительный анализ нарративного подхода и святоотеческого отношения к Священному писанию. В конце статьи делается вывод о том, что нарративный метод и православная традиция одинаково воспринимают Библию как реальное и актуальное событие.

In this article, the author examines the narrative method in biblical studi es in the context of the use of this approach in modern humanities and patristic exegesis. It is indicated that domestic biblical studies are poorly acquainted with foreign narrative criticism. At the same time, the author emphasizes the relevance of mastering the narrative method in Russian church science. The article characterizes the narrative method in modern humanities and shows the origins of narrative criticism of the Bible. The author systematized the main methodological principles of narrative analysis in relation to the analysis of the biblical text. The main part of the publication is a comparative analysis of the narrative approach and the patristic model of attitude to the Holy Scriptures. At the end of the article, it is concluded that the narrative method and the Orthodox tradition equally perceive the Bible as a real and relevant event.
Overview of the International Scientific Conference “Man and the Church in the Christian Thought of Nicholas Berdyaev” (Moscow, March 5–6, 2024)
Authors: Пантуева Я.Р.
Published: September 2024

5–6 марта 2024 г. в Свято-Филаретовском институте (Москва) прошла международная научная конференция «Человек и церковь в христианской мысли Николая Бердяева», посвященная 150-летию со дня рождения философа. Организатором конференции совместно с СФИ стал Институт мировой литературы (ИМЛИ) имени А. М. Горького РАН (Москва). На конференции присутствовали участники из 7 стран (помимо России, это Бельгия, Болгария, Великобритания, Греция, Канада, Латвия), представлявшие 23 светских и церковных учебных и научных учреждения. Формой проведения конференции стали творческие лаборатории, предполагающие как выступления экспертов, в своих сообщениях отвечающих на предложенные вопросы, так и возможность свободного высказывания каждого из присутствующих.

On March 5–6, 2024, the St. Philaret Institute (Moscow) hosted the international scientific conference “Man and Church in the Christian Thought of Nikolai Berdyaev,” dedicated to the 150th anniversary of the philosopher’s birth. The conference was organized jointly with the St. Philaret Institute by the Gorky Institute of World Literature (IMLI) of the Russian Academy of Sciences (Moscow). The conference was attended by participants from 7 countries (in addition to Russia, these were Belgium, Bulgaria, Great Britain, Greece, Canada, and Latvia), representing 23 secular and church educational and scientific institutions. The conference was held in the form of creative laboratories, which included both expert presentations, answering questions in their reports, and the opportunity for each of those present to speak freely.
New Equation for Gas-Liquid/Solid Phase Transition
Authors: Ni Henmei , Zhu Bing
Published: September 2024

A new and concise equation for the gas-liquid or gas-solid phase transition is proposed based on the theory that the heat exchanges between a gas and its surroundings via the phase transition. Given that it is reversible, P=(1-x_2)RT/V_G and x_2=V_L/V_G e^(3/2-(π^α mg)/(RTV_G )). Similar to van der Waals’s equation for real gases, a factor of molecular interaction α is introduced in the form of system potential. Hence, it is also the state equation at saturation. P-V-T saturation data of 79 substances issued by the National Institute of Standards and Technology (NIST) are used as standards to calibrate the equation and determine α. As a result, the equation fits all substances well. The system potential is indispensable only near Tc in a narrow temperature region where the gas molar volume (VG) is comparable to the liquid (VL). It indicates that the system potential is achieved through short-term repulsive interactions rather than attractive ones. Tc corresponds to the temperature with a molar fraction of liquefaction x2 = 60-70%, at which the heat exchange is interrupted. α of each substance is determined by simulation. It seems to fall in the series: -2/3, -1/3, 0, 1/3, 2/3, 1, and 4/3.
In Crystallo O2 Cleavage at a Preorganized Triiron Cluster
Authors: Lee Heui Beom , Ciolkowski Nicholas , Field Mackenzie , Marchiori David , Britt R. David , Green Michael T. , Rittle Jonathan
Published: September 2024

In Nature, the four-electron reduction of O2 is catalyzed at preorganized multimetallic active sites. These complex active sites often feature low-coordinate, redox-active metal centers precisely positioned to facilitate rapid O2 activation processes that obviate the generation of toxic, partially-reduced oxygen species. Very few biomimetic constructs simultaneously recapitu-late the complexity and reactivity of these biological cofactors. Herein, we report solid-state O2 activation at a triiron(II) active site templated by phosphinimide ligands. Insight into the structure of the O2 reduction intermediates was obtained via in crystallo O2 dosing experiments in conjunction with spectroscopic, structural, magnetic, and computational studies. These data support the in situ formation of an Fe2IIIFeIV-dioxo intermediate upon O2 exposure that participates in oxygen atom and hydrogen atom transfer reactivity with exogenous substrates to furnish a stable FeIIFe2III-oxo species. Combined, these stud-ies provide an extraordinary level of detail into the dynamics of bond forming and breaking processes operative at complex multimetallic active sites.
Discovery of a broad-spectrum, fluorinated macrobicyclic antibiotic through chemical synthesis
Authors: Tresco Ben , Wu Kelvin , Ramkissoon Antonio , Aleksandrova Elena , Purdy Michael , See Dominic , Liu Richard , Polikanov Yury , Myers Andrew
Published: September 2024

We report the discovery through chemical synthesis of BT-33, a fluorinated macrobicyclic oxepanoprolinamide antibiotic. BT-33 potently inhibits the growth of multidrug-resistant clinical isolates of Gram-positive and Gram-negative bacteria and has an extended half-life in vivo relative to its predecessors cresomycin and iboxamycin. We report structure-activity relationships within the macrobicyclic substructure, which reveal structural features that are essential to the enhanced potency of BT-33 as well as its increased metabolic stability. We determine the structure of BT-33 in complex with the bacterial ribosome by X-ray crystallography, analysis of which suggests that the newly introduced fluorine atom makes an additional Van der Waals contact with nucleobase G2505. Finally, we show that the C7-methyl group of BT-33 rigidifies the macrocyclic ring in a conformation that is highly preorganized for ribosomal binding by using variable-temperature 1H-NMR experiments, density-functional theory calculations, and vibrational circular dichroism spectroscopy to compare macrobicyclic homologs of BT-33 and a C7-desmethyl analog.
Physics-informed dual-objective optimization of high-entropy-alloy nanozymes by a robotic AI chemist
Authors: Luo Man , Xie Zikai , Li Huirong , Zhang Baicheng , Cao Jiaqi , Huang Yan , Zhu Qing , Chen Linjiang , Jiang Jun , Luo Yi
Published: September 2024

Engineering artificial nanozymes as substitutes for natural enzymes presents a significant scientific challenge. High entropy alloys (HEAs) have emerged as promising candidates for mimicking peroxidase (POD) activity thanks to their unique properties and versatility. However, designing or discovering HEAs that surpass the catalytic efficiency of natural horseradish peroxidase involves complex challenges, often hindered by the multidimensional nature of HEAs’ compositional variability and the intricate interplay of enzymatic behaviours. Therefore, an intelligent and efficient approach to accelerate this discovery is crucial. In this study, we address these challenges by deploying a robotic artificial-intelligence chemist equipped with theoretical calculations, machine learning, Bayesian optimization, and on-the-fly data analysis by a large language model (LLM). Our approach centres on a physics-informed, multi-objective optimization framework that simultaneously optimizes multiple desirable properties of nanozymes, including maximum reaction rate and substrate affinity, ultimately optimizing catalytic efficiency. By integrating an auxiliary knowledge model based on physical insights and collaborative decision-making enabled by LLM-in-the-loop into Bayesian optimization, we enhanced the data-driven discovery workflow. Our physics-informed approach, with instant LLM-in-the-loop feedback, significantly outperformed both random sampling and standard Bayesian optimization. Consequently, we efficiently explored a vast chemical space and identified HEAs with enzymatic properties that significantly exceed those of the most effective catalysts based on HEAs or single atoms reported in the literature, as well as the natural enzyme.
First Principles Optoelectronic Calculations of BeSeO3
Authors: isse Abdullahi
Published: September 2024

Using a first principles approach the optoelectronic properties of monoclinic BeSeO3 is investigated with Density Function Theory (DFT) for application in photonics with a calculated band gap of 4.34 eV, refractive index of 2.16 and absorption coefficient of approximately zero within the visible light range (400-700 nm) such that BeSeO3 is characterized to be a wide bandgap semiconductor with stable optical transmission
Chalcophilic Interactions: Rhenium-Sulfido and -Dithiolato Corroles
Authors: Alemayehu Abraham , Settineri Nicholas , Lanza Arianna , Ghosh Abhik
Published: September 2024

The high-temperature (~180 °C) interaction of free-base meso-triarylcorroles and Re2(CO)10 followed by exposure to PCl3 and thiols (or elemental sulfur) affords rhenium-sulfido corroles in 67-76% yields. The use of shorter reaction times, lower temperatures (~130 °C), and a dithiol (e.g., ethane-1,2-dithiol) also allows the isolation of rhenium-dithiolato corroles, presumptive intermediates on the path to ReS corroles. The ReS corroles exhibit high thermal stability and two reversible oxidations and reductions in their cyclic voltammograms, with redox potentials nearly identical to those observed for analogous ReO corroles. The electrochemical HOMO-LUMO gaps of the complexes, at 2.2 eV, are consistent with ligand-centered oxidation and reduction. The UV-vis spectra of the ReS complexes, on the other hand, differ significantly from those of their ReO counterparts. Scalar-relativistic DFT calculations suggest that this difference reflects low-energy LUMO+2 and LUMO+3 levels, consisting of Re-S π-antibonding interactions; the ReO corroles, in contrast, exhibit a larger LUMO+1/LUMO+2 gap, as expected for a relatively classical Gouterman-type metalloporphyrin analogue. The high stability of ReS corroles is consistent with geochemists’ view of rhenium as a moderately chalcophilic element (i.e., one that partitions into sulfide melts) as well as with a recent quantitative analysis of thiophilicity, which indicates that rhenium’s oxophilicity and thiophilicity are pretty much evenly balanced.
Étude des outils pour mesurer la relation pédagogique en vue d’une utilisation en contexte postsecondaire
Authors: Kozanitis Anastassis , Farand Patrice , Thibault François
Published: September 2024

La majorité des études portant sur la relation pédagogique a été menée auprès d’élèves du primaire et du secondaire. Les études qui s’intéressent aux étudiants du postsecondaire sont beaucoup moins nombreuses, malgré l’importance des retombées qu’elle peut avoir pour eux. L’objectif est d’explorer les écrits scientifiques qui portent spécifiquement sur la mesure de la relation pédagogique afin d’identifier les instruments de mesure pertinents pour le contexte postsecondaire. Les résultats montrent que la majorité des chercheurs ont recours au questionnaire autorapporté pour mesurer le concept de la relation pédagogique. Il n’existe toutefois pas de consensus sur la manière d’opérationnaliser ce concept. Pour certains, il s’agit d’un construit multidimensionnel, alors que d’autres évoquent la possibilité d’un construit bidimensionnel, voire unidimensionnel.
Personal Practical Knowledge and Effective Teaching: A Study of Turkish Teachers Teaching English as a Foreign Language
Authors: Yalcin Arslan Fadime , Erdem Ayse Nur
Published: September 2024

The main aim of this study was to investigate English as a foreign language (EFL) teachers’ personal practical knowledge concerning their perceptions of effective teaching. The qualitative descriptive study employed semi-structured interviews and observations to investigate the impact of personal practical knowledge on the perceptions of teaching effectiveness among English as a foreign language teachers in Turkey. Seven English as a foreign language teachers currently teaching in three public education institutions participated in the study. Inductive content analysis was used to analyse the findings, which revealed that the characteristics of effective teaching, as practised by teachers in their settings, included classroom dynamics, students’ motivation, teacher engagement, assessment and engagement strategies in education, and an empowering environment for active learning.
PISA 2003 E 2012: UMA ANÁLISE COMPARATIVA DAS COMPETÊNCIAS EM MATEMÁTICA DOS ESTUDANTES
Authors: Lima Paulo Vinícius Pereira de , Moreira Geraldo Eustáquio
Published: September 2024

Este texto apresenta uma análise comparativa de desempenho dos estudantes brasileiros no Programa Internacional para Avaliação de Alunos (Pisa), de 2003 e 2012, em termos de resultados em Matemática, bem como a descrição das relações entre os resultados desses anos. A escolha dos anos de análise (2003-2012) se deve ao domínio principal avaliado dentro dos ciclos em Matemática. A metodologia utilizada foi de abordagem qualitativa e exploratória e o método de pesquisa foi a análise descritiva e comparativa com foco nas edições. Os resultados evidenciaram que as proficiências médias em Matemática dos estudantes brasileiros têm aumentado com o tempo. No entanto, estamos longe de alcançar a média de proficiência exigida pela OCDE. Apenas 20% dos estudantes brasileiros estão no nível 2, considerado pela OCDE como o mínimo aceitável de proficiência, e uma inexpressiva parcela de estudantes alcançaram os níveis mais elevados da escala em Matemática, que expressa o desafio significativo que enfrentamos em elevar os padrões de educação e promover um ensino mais eficaz e abrangente. Conclui-se que há a necessidade de mais pesquisas voltadas para as possíveis causas do baixo desempenho dos estudantes brasileiros no Pisa e de indicativos de superação desses resultados, além de precisar de ensino que proporcione a esses estudantes o desenvolvimento de habilidades Matemática.
EDUCAÇÃO PARA A SUSTENTABILIDADE E AGENDAS AMBIENTAIS NAS ESCOLAS: POR UMA FORMAÇÃO AMPLA E CONVERGENTE COM AS NECESSIDADES SOCIOAMBIENTAIS ATUAIS
Authors: Araújo Magnólia Fernandes Florêncio de , Medeiros Maria Luisa Quinino de , Silva Natanael Charles da
Published: September 2024

A implementação da Educação para a Sustentabilidade é estratégica, já que ela possibilita que alunos tenham uma visão ampliada da realidade, percebendo os problemas do planeta, suas interconectividades e vislumbrando possíveis soluções, sendo necessário que os professores sejam formados nessa perspectiva. Assim, o objetivo deste estudo foi discutir sobre a compreensão que docentes da educação básica possuem sobre Educação para a Sustentabilidade e desenvolvimento sustentável, bem como sobre o uso que fazem de matérias didáticos livres sobre estes assuntos em suas aulas. A pesquisa qualitativa fez uso de questionários aplicados com docentes. Verificou-se que os professores trabalham conceitos e princípios inerentes a Educação para a Sustentabilidade de forma fragmentada e até desconhecem o próprio termo em si. Também não são estimulados a se articularem para buscar materiais públicos que foram produzidos, nos últimos anos, alinhados à política das agendas ambientais (a exemplo da Agenda 2030) e aos princípios da sustentabilidade, bem como esses materiais também não são devidamente divulgados nas escolas em que trabalham. Isso denota o quanto a discussão sobre sustentabilidade ainda é frágil no campo educacional, sendo recomendadas medidas urgentes para reversão desse fato.
DESIGN UNIVERSAL PARA APRENDIZAGEM NO ENSINO DE CIÊNCIAS NO BRASIL
Authors: Menezes Joao Paulo Cunha de
Published: September 2024

Este estudo examina a adoção do Design Universal para Aprendizagem no ensino de Ciências no Brasil através de uma revisão sistemática de literatura de 2014 a 2023. A análise identificou uma prevalência de publicações no estrato Qualis A3, refletindo um espectro de impacto diversificado. As publicações foram categorizadas em quatro áreas principais: revisões do estado da arte, desenvolvimento de recursos didáticos inclusivos, estudos de caso práticos, e inovação em planejamento de ensino. Os resultados destacam progressos na integração do DUA, mas também a necessidade de mais recursos e estratégias pedagógicas para uma educação mais inclusiva no ensino de Ciências.
AI enhanced eye detection wheelchair with smart monitoring using deep learning
Authors: Gowtham Priya L. , Pavithra S. , Prema S. , Sanmathi L.
Published: September 2024

People with high-level cervical spinal cord injuries can experience significant impairments in their ability to control their environment, including challenges in operating a smartphone or navigating a power wheelchair. The use of eye- tracking technology has been crucial in improving communication and control for individuals with tetraplegia. However, traditional eye-tracking systems often have limitations in terms of accuracy, calibration time, and practicality. To overcome these limitations, researchers have explored the use of Convolutional Neural Networks (CNNs) in AI-enhanced eye-tracking technology. CNNs are a type of deep learning algorithm that can learn complex patterns in image data, allowing for more accurate and reliable eye tracking. AI-enhanced eye tracking that utilizes triple blinking is a novel approach showing great potential for improving the accuracy and efficiency of eye tracking technology. By employing advanced machine learning algorithms, this method can detect and track eye movements based on the number of blinks, providing a more reliable and efficient way to interact with digital devices. This technology has the potential to revolutionize the way people engage with digital devices, making them more accessible and user-friendly for individuals with disabilities or impairments. The findings related to AI-enhanced eye tracking using triple blinking suggest that it can be a viable alternative to traditional eye tracking technology, which can be costly, time-consuming, and difficult to use. Furthermore, this approach is highly customizable and can be adapted to meet the specific needs and preferences of individual users. As such, it has the potential to significantly enhance the quality of life for individuals with motor impairments, visual impairments, or other disabilities that affect their ability to use traditional eye tracking technology. AI- enhanced eye tracking using triple blinking is a promising innovation that could contribute to a more inclusive and accessible digital world. With continued research and development, even more innovative solutions and applications for this technology are expected in the future.
Microplastic ingestion by pelagic gooseneck barnacles (Lepas spp.) and other insights on their biology and ecology in the South Pacific Ocean
Authors:   , Davenport Thomas Luca
Published: September 2024

Pelagic gooseneck barnacles from genus Lepas are the most common rafting organism in the open ocean. Attaching to floating objects, they are a foundational part of the rafting ecosystem. Lepas barnacles are thought to be the most capable of ingesting microplastics of any rafting life. Ten large tsunami detection buoys (DART), and two smaller buoys, around New Zealand and in the wider Southwest Pacific Ocean were sampled for Lepas specimens. These samples were analysed for their species and morphological characteristics and dissected to find microplastics. This study revealed that Lepas barnacles do ingest microplastics in the study area, with 1.6% of barnacles having microplastics in their digestive system. Sites which were at latitudes modelled in a previous study to have the highest microplastic density also had the most barnacles with ingested microplastic. Inedible objects such as pumice were also found in the barnacles digestive systems. The lack of evidence for any negative effects of microplastics on pelagic gooseneck barnacles suggests they are not a viable bioindicator for the effects of microplastic pollution. However, these species are still useful for understanding the relative bioavailability of microplastics if dissected to compare to other studies from around the world.

This study found that Lepas species in the study area have very clear latitudinal distributions. These distributions are likely a result of temperature preferences and ocean dynamics. The capitulum and peduncle lengths of Lepas specimens decreased towards the equator, with significant differences in peduncle size between species. The peduncle lengths of the barnacles were longer at sites with higher densities of Lepas spp., but also were significantly longer on the float of the buoys near the surface than 2 metres deeper on the transducers, perhaps due to increased competition for space. A form of optimal foraging may also be utilised by L. anatifera which often settles in less optimum locations away from its competitor L. testudinata. There was a very strong linear increase in the proportion of spotted barnacles with decreasing latitude towards the equator. The translucency of a barnacles peduncle was strongly associated with its position on the buoy, suggesting that sun-exposure causes the darkening of Lepas peduncles. The highest minimum growth rate for a Lepas barnacle peduncle was estimated as 1.1 mm per day. Overall, this study has begun to reveal that Lepas barnacles show many interesting and unexplained patterns which future work will explore further.
Diagnostic and Therapeutic Analysis of Coronary Intervention in Cardiovascular Medicine for Clinical Purposes
Authors: Chen Xingjian
Published: September 2024

Objective: To explore the impact of coronary intervention in cardiovascular medicine on the diagnosis and treatment of the clinic. Methodology: 69 patients with cardiovascular diseases included in the Knowledge Network Open Database between January 2022 and December 2023 were selected for the study. All patients were clinically diagnosed with cardiovascular internal medicine-related diseases, and all received coronary intervention. The study mainly observed the coronary angiographic results after the intervention, the patient’s cardiac function indexes and complications after the intervention. Results: The post-interventional imaging results, cardiac function indexes and complication rates were significantly better than those before the intervention, and the difference was statistically significant (P < 0.05). Conclusion: Coronary intervention in cardiovascular medicine is a safe and effective treatment for patients with cardiovascular diseases. Interventional therapy can significantly improve patients’ coronary artery lesions and cardiac function indexes, alleviating their clinical symptoms and improving their quality of life.
Utilization Management: Walking the Line Between Patient Needs and Healthcare Economics – Short Communication
Authors: Shanmugam Kirubanandan
Published: September 2024

Utilization management plays a crucial role in healthcare by optimizing resource allocation, improving patient outcomes, and effectively controlling costs. By balancing patient needs with economic considerations, healthcare institutions can ensure efficient and sustainable service delivery. Utilization management encompasses various strategies, including prior authorization, concurrent review, and clinical pathways, to enhance care quality, manage expenses, and streamline resource use. The benefits of utilization management include cost containment, improved care standards, and the implementation of consistent treatment guidelines, thereby increasing the overall efficiency and effectiveness of healthcare delivery.
Impact of a High-Quality Nursing Model on Patient Outcomes in Rheumatology: A Randomized Controlled Study
Authors: Li Jing
Published: September 2024

Objective: To enhance the overall nursing effectiveness in the rheumatology and immunology department, explore specific strategies to improve nursing quality using a high-quality care model, and develop a comprehensive nursing system. Methods: A total of 120 hospitalized patients with rheumatoid arthritis from 2022 to January 2024 were selected. These patients were randomly divided into two groups: an observation group (60 patients) and a control group (60 patients). The control group received conventional nursing care, which included creating a good care environment, providing drug guidance, and offering psychological support. In the observation group, a high-quality nursing model was implemented with a focus on meeting the specific needs of the patients. The two groups were compared in terms of complication rates, treatment compliance, nurse-patient disputes, patient satisfaction with nursing care, sleep quality (PSQI score), and pain levels (VAS score). Results: The incidence of complications in the observation group was 3.33%, significantly lower than that of the control group, with a statistically significant difference (P < 0.05). Nursing compliance in the observation group was 100%, and patient satisfaction was 96.67%, both higher than in the control group, with a statistically significant difference (P < 0.05). Additionally, the VAS pain score in the observation group decreased to 2.12 ± 1.89, and the PSQI sleep quality score decreased to 6.89 ± 0.33, both lower than in the control group, with statistically significant differences (P < 0.05). Conclusion: Focusing on the needs of patients through a high-quality nursing model provides targeted care that improves overall nursing effectiveness for patients with rheumatoid arthritis. This approach enhances patient satisfaction with nursing care, increases treatment compliance, reduces the incidence of complications and nurse-patient disputes, improves sleep quality, and alleviates pain. This model holds significant value for broader applications.
Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension
Authors: Shao Miao , Huang Jin Tian Jacinda , Wu Wentao
Published: September 2024

Objective: To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy. Methods: A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study. All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets, consisting of perindopril 10 mg/day and amlodipine 5 mg/day. Blood pressure measurements, including both diastolic and systolic pressures, were taken at baseline, and after 2, 4, 6, and 8 weeks of treatment. Results: After 8 weeks of treatment, there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline (P < 0.0001). Specifically, the average systolic blood pressure decreased by 24.45 ± 13.75 mmHg, and the average diastolic blood pressure decreased by 13.37 ± 8.40 mmHg. The overall heart rate showed no significant changes during the treatment period. Conclusion: A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment. These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension.
Analysis of the Effects of Different Synthesis and Processing Methods on Circular RNA Integrity, Protein Expression, and Removal of Immunogenic Impurities
Authors: Wang Shao , Saw Tzuen Yih , Hong Zebin , Liao Kuo Chieh , Song Haiwei , Wan Yue
Published: September 2024

Circular RNAs (circRNAs) are emerging as a promising alternative to messenger RNAs (mRNAs) in gene delivery applications due to their enhanced stability and translation. Developing circRNA-based therapeutic platforms requires efficient manufacturing of circRNA with broad scalability. However, the permuted intron-exon (PIE)-based circRNA production commonly used to date involves complex RNA synthesis, circularization, precursor RNA digestion, and impurity removal steps that have limited practical applications. While co-transcriptional circularization could effectively streamline circRNA production, and both cellulose/phosphatase treatment and high-performance liquid chromatography (HPLC) have demonstrated their reliability in mRNA manufacturing, their potential effects on the quality, translation, and reactogenicity of circRNA remained to be fully investigated. Here, using circRNAs systematically manufactured through three independent workflows, we comprehensively examined the utilities of these RNA synthesis and processing methods in circRNA production by comparing the integrity, translation, and immunogenicity of their circRNA products. We began by manufacturing a mNeonGreen (mNG)-encoding circRNA through these workflows and subsequently assessed circRNA integrity via E-gel EX electrophoresis. Protein expression was then monitored in HEK 293T, A549, and DC2.4 cells at 72 hours post-transfection. Finally, we evaluated the immunogenicity of these circRNAs by measuring their interferon beta (IFN-β) induction in A549 cells at 4 hours post-transfection. Using HPLC purification over cellulose and phosphatase treatment resulted in 10–14% higher circRNA enrichment by reducing nicking associated with processing conditions. Protein expression remained consistent across circRNAs from different workflows (P > 0.05), demonstrating that co-transcriptional circularization produces circRNA with translation levels comparable to those obtained from the conventional PIE method. Moreover, both cellulose/phosphatase treatment and HPLC purification effectively minimized IFN-β induction of the purified circRNAs, confirming their reliability in removing immunogenic impurities introduced during in vitro transcription and their compatibility with the co-transcriptional circularization strategy. Collectively, our results provide valuable insights for improving the production efficiency and scalability of circRNA manufacturing that are crucial for addressing key bottlenecks in the development of circRNA-based therapeutic applications.
The Effect of Immunotherapy on the Gut Microbiota, Intestinal Barrier, and Immune Function in Patients with Gastric Cancer
Authors: Chen Kui , Hu Yan
Published: September 2024

Objective: To explore the effect of immunotherapy on the gut microbiota, intestinal barrier, and immune function in patients with gastric cancer. Methods: From July 2023 to July 2024, 60 patients with gastric cancer from our hospital were randomly divided into two groups, the control group and the study group, with 30 patients in each group. The control group received conventional treatment, while the study group received immunotherapy. A comparative analysis was conducted between the two groups on gut microbiota content (Bifidobacterium, Fusobacterium nucleatum, Streptococcus, Lactobacillus acidophilus), intestinal barrier indicators [D-lactate (D-LA), diamine oxidase (DAO), lipopolysaccharide (LPS)], immune function indicators [Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin M (IgM)], adverse reactions, and treatment effects. Results: After treatment, the content of Bifidobacterium and Fusobacterium nucleatum in the study group was higher than in the control group, while the content of Streptococcus and Lactobacillus acidophilus was lower than in the control group (P < 0.05). The levels of D-lactate and DAO in the study group were lower than in the control group, while the LPS level in the study group was higher (P < 0.05). The levels of IgA and IgG in the study group were lower than in the control group, and the IgM level was also lower than in the control group (P < 0.05). After treatment, the total incidence of adverse reactions in the study group was lower than in the control group (P < 0.05). The overall treatment efficacy rate in the study group was higher than in the control group (P < 0.05). Conclusion: Immunotherapy in patients with gastric cancer can improve gut microbiota, intestinal barrier, and immune function, reduce the occurrence of adverse reactions, and promote better clinical treatment outcomes, making it worthy of clinical recommendation.
Avaliação do nível de funcionalidade em pessoas com sequelas após Chikungunya em um município do Piauí
Authors: Leal de Carvalho Eliene , Pinheiro Machado de Freitas Coelho Nayana , Da Silva Oliveira Vinicius Alexandre , Silva Almeida Iranary Ohio , Leal de Carvalho Eliane , Marques Damasceno Costa Silvana Thamyres
Published: September 2024

Objetivo: Avaliar o nível de funcionalidade em pessoas com sequelas após sintomatologia de Chikungunya. Métodos: Trata-se de um estudo transversal, realizado no período de junho a agosto de 2023, no município de Bocaina- PI. Foram aplicados três instrumentos de pesquisa: questionário de sintomatologia característica de Chikungunya elaborado pelos próprios pesquisadores, Nordic Questionnaire of Musculoskeletal Symptoms (NQMS) e WHO Disability Assessment Schedule (WHODAS 2.0). Os dados foram tabulados  no Microsoft Excel com a  análise estatística descritiva  calculada por meio do GraphPad Prism 10. Utilizou-se o software IBM Statistical Package for the Social Sciences- SPSS para realizar o teste de Shapiro-Wilk e o Coeficiente de Spearman para correlacionar os domínios. Resultados:  A amostra foi composta por 25 participantes, sendo 19 (76%) mulheres e 6 (24%) homens, com queixas dolorosas marcantes nas articulações dos tornozelos (80%) e das mãos (76%). As funções e estruturas do corpo foram caracterizadas na CIF, nas subdivisões das categorias b280, de s710 a s760 e no WHODAS 2.0 os domínios mobilidade e autocuidado apresentaram correlação moderada positiva de 0.622, com p = 0.001. Conclusão: Após análise, demonstrou-se que a infecção pelo vírus Chikungunya pode causar dores nas articulações, que podem se fazer presentes após 1 ano de infecção.
Botanical and geographical analysis of flora of the Kologrivsky Forest Nature Reserve
Authors: Lebedev A. V. , Krinitsyn I. G. , Gostev V. V. , Gosteva D. Yu.
Published: September 2024

Regional floras are formed by species whose habitats are characterized by different sizes and types, which is associated with the stages of development of the flora against the background of the influence of various natural and anthropogenic factors. The latitude-longitudinal analysis makes it possible to identify geographical relationships and to determine the geographical type of the flora. The aim of the work is to perform a geographical analysis of the flora of the Kologrivsky Forest Nature Reserve (Kostroma region). The current floristic list was compiled on the basis of the authors’ field studies from 2010 to 2023, as well as data from literature and herbarium collections. Literature sources, open electronic resources (GBIF, INaturalist) containing data on species records were used to assign species to a specific floristic complex and habitat type. Zonally, the flora of the Kologrivsky Forest Nature Reserve is characterized by a predominance of plurizonal (47%), taiga (28%) and subtaiga (18%) floristic complexes, nemoral species account for 5%, and hypoarctic-boreal and forest-steppe species account for 1% each, which is consistent with the zonal position of the study area. In terms of longitude, the leading habitat types in the flora of the reserve are Eurasian (28%), Holarctic (25%), Euro-Siberian (20%) and European (10%). The remaining longitudinal groups account for 17% of the total number of species identified. The predominance of species with large ranges, the heterogeneous composition of the latitudinal and longitudinal groups, and the absence of endemic taxa indicate the migratory nature of the flora and its relative youth. The studies carried out make it possible to monitor the dynamics of the relationship the between latitudinal and longitudinal groups of vascular plants and to identify further directions of flora migration.
Effect of fitness boxing on functional indices of cardiovascular system of female students
Authors: Rakovetskiy A. I. , Sorokin D.  V. , Soparev A. A.
Published: September 2024

The article presents the material on the effect of fitness training on the cardiovascular system of female students. The study was conducted on the basis of the Russian State Agrarian University – Moscow Timiryazev Agricultural Academy during the academic year 2022-2023. The author’s method of fitness boxing in the educational process of Physical Training in a higher educational institution was tested. The essence of the experiment is that the smaller the difference in heart rate before and during a special exercise, the greater the endurance of the heart muscle. As a result of the conducted research, the level of physical fitness of female students was increased by 51.5% and the cardiovascular system was improved by 39.1% in the course of fitness training. The results of the experimental work allowed to select a number of special fitness box exercises as control exercises for the assessment of the level of physical fitness and the degree of adaptation of the cardiovascular system to physical load in female students.
SYNERGISTIC ARCHITECTURE FOR AUTOMATED DETECTION OF TARGETED INFORMATION ATTACKS
Authors: Kosohov Oleksandr
Published: September 2024

Detecting targeted attacks in order to counteract them in a timely manner requires an operational analysis of the information space using specialized monitoring systems. Such systems should provide not only hardware analysis of information attacks, but also quantitative analysis of the dynamics of these attacks, taking into account their specifics. In the event of an attack, the intensity of incidents of the attack flow, which is a time series by the number of information incidents over a certain period of time (usually per day), may contain information both about the fact of a targeted attack and about the phase of the scenario in which it is carried out. It is noted that the current detection of information security threats is mainly a manual process in which teams of analysts monitor suspicious events using auxiliary tools. The ability of analysts to recognize suspicious activity and the authority to make decisions about threats put people at the centre of the threat detection process. It is noted that excessive reliance on human abilities can lead to a large number of undetected threats. The author substantiates the need for a new detection paradigm that would be largely automated, but in which analysts would retain situational awareness and control over the process. The article proposes a synergistic detection process that rationally uses the advantages of human cognition and machine computing, while mitigating their weaknesses. The paper presents the structure of analyst discovery in the cycle and describes the types of required interactions between the evidence collection system, inference engine, and analyst. the paper presents the structure of analyst discovery in the cycle and describes the types of required interactions between the evidence collection system, inference engine, and analyst. The use of queries and operations to improve detection is demonstrated and the basis for a more detailed operational definition of interactions is laid.
DECISION-MAKING ON THE BASE OF LINEAR OPTIMIZATION IN THE PROCESS OF MANAGEMENT OF INFORMATION SECURITY RISKS
Authors: Zhdanovа Yuliia , Shevchenko Svitlana , Spasiteleva Svitlana , Sokulsky Oleg
Published: September 2024

Information security is a critical field in which many different factors and constraints must be taken into account to ensure that data and infrastructure are protected. One of the main challenges in this area is the optimal allocation of limited resources between different security measures, which requires the use of mathematical methods to find optimal solutions. This article discusses the use of linear programming methods to solve problems related to optimizing the costs of information security risk reduction measures. The article reviews scientific sources on the applied aspect of linear programming for risk assessment and information security risk management. The article shows the process of building a model based on a linear programming problem, starting with the formalization of the problem, selection of the objective function and constraints, and ending with obtaining an optimal solution with its analysis and interpretation. The model in the form of a linear programming problem allows optimizing the total costs of information security, taking into account the chosen direction of optimization and given the given constraints on resources - budget, time, technical and other. The article presents the use of linear optimization based on the SWOT analysis of information security risks, which allows organizations to systemize and specify the risk management process, directing limited resources to the most critical areas and ensuring optimal protection of data and information systems. The obtained results show that the use of linear programming methods allows to achieve a significant optimization of information security costs, providing a high level of protection. Among the promising directions for further research are multi-criteria optimization and dynamic planning with consideration of time changes in risks and costs. This study can be used as an illustrative example of intersubject connections of the disciplines of the specialty 125 Cybersecurity and information protection in the educational activities of students of this specialty.