bluuebunny/crossref_metadata_2025 huggingface dataset:
Partial versus radical nephrectomy for renal cell carcinoma
Authors: Jhaveri Kenar D , Pierorazio Phillip , Hu Susie L
Published: January 2019

Chronic kidney disease risk is increased among patients with renal cell carcinoma, particularly for those with preexisting chronic kidney disease (including proteinuria) but also for those with comorbidities such as diabetes mellitus, hypertension, and obesity. Among those with small renal masses without complex disease, partial nephrectomy should be prioritized given favorable pathologic prognosis and mortality related to cardiovascular disease or chronic kidney disease. Nephrologists should actively participate in a multidisciplinary team to help formulate individualized treatment which will help preserve residual kidney function where possible.
Peer-Interaction Strategies: Fostering Positive Experiences for Students With Severe Disabilities in Inclusive Music Classes
Authors: Draper Ellary A. , Brown Laura S. , Jellison Judith A.
Published: January 2019

Too often, students with disabilities in regular classrooms have limited access to the regular curriculum, and for students with severe disabilities, interactions are often with paraprofessionals, not typical classmates. The present study is grounded in action research methods in that an elementary teacher and the authors worked together for the purpose of designing, implementing, and evaluating interaction guidelines between her students with severe disabilities and their typically developing classmates. Overall, instruction and implementation of peer-interaction activities for working together and helping each other were efficient and resulted in high rates of positive interactions. Although the students with disabilities needed different kinds of support, they were capable of participating in a wide-range of music activities and interacting with their typical classmates. Differences in frequencies and quality of interactions are attributed primarily to task complexity, individual needs, and partner assignments.
Inotuzumab: from preclinical development to success in B-cell acute lymphoblastic leukemia
Authors: Wynne Joseph , Wright David , Stock Wendy
Published: January 2019

Inotuzumab ozogamicin (InO) is a recently US Food and Drug Administration–approved antibody–drug conjugate for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (ALL). InO consists of a CD22-targeting immunoglobulin G4 humanized monoclonal antibody conjugated to calicheamicin. Although initially developed for the treatment of non-Hodgkin lymphoma (NHL) because of activity in preclinical models and high response rates in indolent lymphomas, a phase 3 trial was negative and further development focused on CD22+ ALL. Although results in NHL were disappointing, parallel testing in early-phase trials of CD22+ ALL demonstrated feasibility and efficacy. Subsequently, the randomized phase 3 Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia trial showed that InO was superior to standard of care regimens with a significantly improved complete remission (CR) rate in patients with relapsed/refractory disease (80.7% vs 29.4%, P < .001). Patients achieving CR with InO also had a significantly higher rate of undetectable minimal residual disease compared with chemotherapy (78.4% vs 28.1%, P < .001). InO-specific side effects, including veno-occlusive disease, have been an ongoing area of concern, and consensus guidelines for minimizing toxicities are now available. Ongoing trials are investigating the combination of InO with other agents in the relapse setting and the addition of InO to frontline therapy. This review details the preclinical and clinical development of InO, focusing on how best to use it and future directions for further development.
RETRACTED ARTICLE: Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer
Authors: Dong Huaying , Hu Jianguo , Zou Kejian , Ye Mulin , Chen Yuanwen , Wu Chengyi , Chen Xin , Han Mingli
Published: January 2019

Background

Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While long non-coding RNAs (lncRNAs) can modulate cell behavior, the contribution of these RNAs in trastuzumab resistance and metastasis of HER-2+ breast cancer is not well known. In this study, we sought to identify the regulatory role of lncRNA in trastuzumab resistance and accompanied Epithelial-mesenchymal Transition (EMT) process in advanced HER-2+ breast cancer.

Methods

Trastuzumab-resistant SKBR-3-TR and BT474-TR cell lines were established by grafting SKBR-3 and BT474 cells into mouse models and subjected to trastuzumab treatment. LncRNA microarray followed by quantitative reverse transcription PCR (qRT-PCR) was carried out to verify the differentially expressed lncRNAs. Western blotting, bioinformatics analysis, immunofluorescence assay and immunoprecipitation assays (ChIP and RIP) were performed to identify the involvement and functional interactions between H3K27 acetylation and terminal differentiation-induced non-coding RNA (TINCR) or between TINCR and its downstream genes including miR-125b, HER-2 and Snail-1. In addition, a series of in vitro and in vivo assays were performed to assess the functions of TINCR.

Results

An increase in both, IC50 value of trastuzumab and EMT was observed in the established trastuzumab-resistant cell lines. The expression level of TINCR was significantly increased in trastuzumab-resistant cells when compared with sensitive cells. Knockdown of TINCR reversed the trastuzumab resistance and the acquired EMT in these cells. TINCR was detected in the cytoplasm of breast cancer cells and could sponge miR-125b, thereby releasing HER-2 and inducing trastuzumab resistance. In addition, Snail-1 was found to be the target gene of miR-125b and overexpression of Snail-1 could reverse the suppressed migration, invasion, and EMT caused by TINCR silencing. The upregulation of TINCR in breast cancer was attributed to the CREB-binding protein (CBP)-mediated H3K27 acetylation at the promoter region of TINCR. Clinically, HER-2+ breast cancer patients with high TINCR expression levels were associated with poor response to trastuzumab therapy and shorter survival time.

Conclusion

TINCR could promote trastuzumab resistance and the accompanied EMT process in breast cancer. Therefore, TINCR might be a potential indicator for prognosis and a therapeutic target to enhance the clinical efficacy of trastuzumab treatment.
Adaptation of multiple regression analysis to identify effective factors of water losses in water distribution systems
Authors: Jang Dongwoo , Choi Gyewoon , Park Hyoseon
Published: January 2019

It is important to manage leaks in water distribution systems by smart water technologies. In order to reduce the water loss, researches on the main factors of water pipe network affecting non-revenue water (NRW) are being actively carried out. In recent years, research has been conducted to estimate NRW using statistical analysis techniques such as Artificial Neural Network (ANN) and Principle Component Analysis (PCA). Research on identifying factors that affect NRW in the target area is actively underway. In this study, Principle components selected through Multiple Regression Analysis are reclassified and applied to NRW estimation using PCA-ANN. The results show that the principal components estimated through PCA are connected to the NRW estimation using ANN. The detailed NRW estimation methodology presented through the study, as a result of simulating PCA-ANN after selecting statistically significant factors by MRA, forward method showed higher NRW estimation accuracy than other MRA methods.
Elastic characteristics of overpressure due to smectite-to-illite transition based on micromechanism analysis
Authors: Qin Xuan , Han De-Hua , Zhao Luanxiao
Published: January 2019

Characterizing the elastic signatures of overpressure of shale caused by the smectite-to-illite transition relies on a good understanding of this mechanism and is also necessary for pore-pressure prediction. Methods of pore-pressure prediction in shales that have undergone smectite-to-illite transition are mostly based on empirical fitting without a quantitative interpretation based on a micromechanism analysis. With upscaled wireline-logging data, two trends of smectite-to-illite transition are categorized by using the crossplot of sonic traveltime and density. Trend I associated with a fluid-expansion scenario exhibits a decrease of sonic velocity with little change in the bulk density, whereas trend II induced by a fluid-loss scenario contains an increase of density with little change in the sonic velocity. The fluid expansion typically gives rise to high-magnitude overpressure and tends to happen when the overlying formations have more shaly contents and low permeability. The fluid loss case tends to have relatively deeper overpressure onsets, and its overlying formations tend to have more sandy contents with relatively high permeability. We develop a modeling framework to capture the elastic and pore-pressure evolution characteristics in shale during the smectite-to-illite transition. With proper bulk volume models, the velocity, density, and pore pressure increase of shale can be computed in the fluid expansion, fluid loss, and a mixture of these two scenarios. After calibration with logging data, rock-physics modeling can quantitatively interpret the rock-property evolution characteristics within the smectite-to-illite transition zone.
On Being and Becoming an Animal: Engelhardt’s Two Notions of Animality
Authors: Chorianopoulou Maria
Published: January 2019

The principal objective of this essay is to briefly present and discuss what could be thought of as Engelhardt's two approaches on animality. The first, rather literal use of the term, refers to non-rational animals stricto sensu, while the second and more important one thematizes humanity's ontological self-degradation resulting from the dominant pleasure-oriented culture of our time. As for the first, aiming to moderate his outright acceptance of animal use, I invoke Dworkin's insights on sanctity, which substantiate a plausible alternative stance. As for the second, I attempt to critically reconstruct the way in which, according to Engelhardt, humanity, having rejected every transcendent inquiry, is increasingly embracing its lower nature. In conclusion, I will hint that this return to animality may be impeded by upcoming challenges that already leave a noticeable imprint on a global scale.
“We Live in the Ruins of Christendom”: Bioethics in a Post-Engelhardtian Age
Authors: Paganini Claudia
Published: January 2019

Hugo Tristram Engelhardt Jr. is a philosopher and a physician who has devoted all his life and all his creative power to developing and promoting a Christian bioethics. At the same time, the American is a personality who polarizes and has received euphoric praise on the one hand and malicious criticism on the other.  This has already been the case during his lifetime and will presumably remain so even after his death, which we wish to commemorate here. In the following contribution I intend to investigate why Engelhardt provokes so different reactions in the scientific community, and I will try to bring closer together the two seemingly irreconcilable parties of Engelhardt admirers and Engelhardt critics. I will do this by focusing on the two most controversial aspects of his research, his critique of the status quo and his concept of an independent Christian bioethics.
Engelhardt on the Common Morality in Bioethics
Authors: Iltis Ana S.
Published: January 2019

Contemporary bioethics is, at least in part, the product of biomedical and sociopolitical changes in the middle to latter part of the 20th century. These changes prompted reflection on deep moral questions at a time when traditional sources of moral guidance no longer were widely respected and, in some cases, were being rejected. In light of this, scholars, policy makers, and clinicians sought to identify a common morality that could be used among persons with different moral commitments to resolve disputes and guide clinical practice and health policy. The concept of the common morality remains important in bioethics. This essay considers the common morality in light of the work of H. Tristram Engelhardt, Jr.
Support workers and nursing associates as coaches
Authors: Stonehouse David
Published: January 2019

This article examines the important role that support workers and nursing associates play in being a coach for other less experienced team members. There is a difference between being a coach and being a mentor and this will be explored. The requirement to be a coach is laid down in both the Code of Conduct for Healthcare Support Workers and Adult Social Care Workers in England ( Skills for Care and Skills for Health, 2013 ) and for nursing associates in the recently amended Nursing and Midwifery Council (NMC) (2018) code. Relevant sections of these two codes will be highlighted. The article will then move on to discuss the importance of planning in advance, so that the best support and development can be attained. Reflection at the end by both the coach and learner is key.
The influence of partners on feeding: A personal reflection
Authors: Halliday Alexandra
Published: January 2019

Research suggests that partner support is one of the biggest determinants of women's health choices ( Scott et al, 2006 ), yet partner inclusion in maternity care is often overlooked. This article critically reflects on a personal encounter with a breastfeeding woman and her husband that highlights these issues. It explores the literature on breastfeeding influences, focusing on partner support and sociocultural background. This personal reflection also examines how greater knowledge of these factors helps to foster more meaningful communication with women and their families.
Growth performances, carcass traits, meat quality, and blood metabolic parameters in rabbits of local Algerian population and synthetic line
Authors: Belabbas Rafik , Garcia Maria de la Luz , Ainbaziz Hacina , Benali Nadia , Berbar Ali , Boumahdi Zoubeida , Argente Maria Jose
Published: January 2019

Aim: The objective of this work was to study the growth performance, slaughter traits, meat quality, and metabolic profile in rabbits of local Algerian population and a synthetic line. Materials and Methods: In total, 120 weaned rabbits were used (60 per group). Growth traits were recorded from weaning (35 days) to slaughter (91 days). At slaughter, carcass traits, meat quality, and metabolic profiles were measured. Results: The synthetic line showed heavier total weight and faster daily weight gain than the local population (+15% and +19%, respectively), better feed conversion (3.92 vs. 4.81 g/g), and heavier weight of cold carcass, and perirenal fat (+15%). No differences were found between the two groups in dressing out percentage, muscular pH, weight of liver, or scapular fat. Wider intestinal villi were found in the synthetic line (+20%, p<0.0001) allowing better absorption surface in this line. The synthetic line also showed higher fat content (3.41% vs. 2.22%, p<0.0001) in the meat and lower protein content (22.02% vs. 18.98%, p=0.0002). Glucose level was 19% higher in the local population than in the synthetic line. Conclusion: The synthetic line is well adapted to the local conditions of Algeria. This line has shown better growth, daily gain, and feed conversion, due to its better intestinal absorption surface.
Amelioration of Salt Tolerance in Soybean (Glycine Max. L) by Plant-Growth Promoting Endophytic Bacteria Produce 1-Aminocyclopropane-1-Carboxylase Deaminase
Authors: Simarmata Rumella , Ngadiman Ngadiman , Rohman Saifur , Simanjuntak Partomuan
Published: January 2019

Salinity is a major abiotic stress that can induce ethylene synthesis beyond the normal limits as plants response to stress and hence reduces crop productivity. The 1-aminocyclopropane-1-carboxylase deaminase (ACCD)-producing bacteria can reduce excessive ethylene synthesis by taking ACC (ethylene precursor) as a nitrogen source. This study showed the possibility of using endophytic bacteria in order to reduce the undesirable effects of salinity. Strain Pseudomonas putida PIR3C and Roultella terrigena PCM8 exhibited promising performance for promoting the growth of plant under salinity stress conditions. The results showed that bacterial inoculation was effective even in the presence of higher salinity levels. Strain P. putida PIR3C was the most efficient strain compared to the other strains and significantly increased shoot length, root length, dry weight, germination percentage, and reduced stem diameter. The role of ACCD in reducing ethylene production under salinity stress conditions was also studied by measuring the evolution of ethylene in vitro by soybean seeds treated with some ACCD bacterial strain. The maximum ethylene lowering capacity was observed in R. terrigena PCM8, the strain reduced ethylene production from 622.81 nmol.g-1(control) to 352.78 nmol.g-1 (43% reduction). The production of α-ketobutyrate, chlorophyll content and germination percentage from P. putida PIR3C was higher than other strains. The results suggested that strain P. putida PIR3C and R. terrigena PCM8 can be employed for salinity tolerance in soybean seedlings and may have better prospects for an amelioration of stress condition.
Diagnosing onychomycosis with dermoscopy and the strategy of early intervention
Authors: Sergeev V. , Sergeev Y.
Published: January 2019

High prevalence of onychomycosis in developed countries is well-acknowledged. Less understanding one may find regarding clinical variability of the disease and the penetration of newer, effective diagnostic techniques to everyday derma- tology practice. Advent of dermoscopy as a diagnostic toolfor common skin and nail pathology may help diagnosing and differentiating onychomycosis in its early stages. Clinical experience gained by Russian dermatologists allows for describing major dermoscopic features of onychomycosis and devising a routine for its early diagnosis and treatment. Rational strategy of early intervention for onychomycosis embraces the population awareness, timely screening and administration of modern specialized forms of antifungals, such as amorolfine 5% lacquer.
Silent hero. The metaphorical role of the ruins of Warsaw in Polish fiction films from 1949 to 1960
Authors: Giza Barbara
Published: January 2019

The article is an analysis of the image of ruins of Warsaw in Polish feature films after World War II. There is a strong tendency to connect this image with the current political (and psychological) situation, from the enthusiasm of rebuilding Warsaw just after the war to the depressive moods of the late fifties and sixties. The ruins of the city are depicted as a symbol of political and social changes in Poland in this article.
Memory images: Holocaust memory in Balkan cinema(s)
Authors: Daković Nevena
Published: January 2019

The aim of this paper is to analyse the shift of the representational and narrative paradigms of Holocaust memory in the Balkan films that belong to two genres – of melodrama and historicalfiction. The hybrid format positons the Holocaust (hi)stories – already caught between forgetting and remembrance – on the unstable ground between trauma and nostalgia; between history and memory; or facts and fiction. The “regained visibility of the Holocaust grant us access” to Balkan past and present and oblige us to investigate the convergence of the history and the memory into Holocaust master narrative of the Holocaust.“Bringing the dark past to light” in cinema has manifold effect. First, the Balkan wave of Holocaustfilms, with its mixed generic performances, offers new answers to the traditional issues of, both, the ethics of memory and the ethics of representation. Second, the analysis of five films reveals that the trauma from the past – resisting the closure – has the potential to powerfully resonate in the present day political crises. Re-dressing the trauma of the past, the films present the future violence while fulfilling “the Holocaust dictum ‘never forget’”. Eventually, new representational paradigm gives consistency to the Balkan (hi)stories of the past and coherence to the identity in the present.
The cinematographic representation of social frames
Authors: Bejko Julian
Published: January 2019

The author of the essay titled «The Cinematographic Representation of Social Frames» analyzes images in the context of representing physical and ontological aspects of reality. He considers Albanian Communist Cinema (1952–1991) taking into consideration the viewer’s perspective in which cinema is treated as a metaphorical place when people learn to read images and can think through images. The author also focuses on following issues: processes of individualization, representation and the problematisation of subjectivity.
Nagość jako strategia promocyjna kina polskiego lat 80.
Authors: Zwierzchowski Piotr
Published: January 2019

The article examines how nudity was used as a promotional strategy in the Polish cinema in the 1980s. In contrast to earlier decades, the Polish movie industry delivered dozens of films that contained female nudity and erotic scenes. Some actresses like Maria Probosz, became automatically associated with such movies. Paradoxically, the Polish cinema of the 1980s was only slightly concerned with the discourse of eroticism. As Maria Kornatowska writes,The shortage of erotic sensibility was compensated by ‘bald nakedness.’’ The reasons for the increased presence of nudity on movie screens stemmed from the transformation of social lifestyle and audiences’ demand, the search for easy profit and the need to de-politicize society. Of significant importance were the influences of the growing video market and western cinema. Projections of nudity were meant to divert attention from the bleak reality of Poland enmeshed in crisis provide a sense of belonging to the Western world, and give mostly male viewers visual pleasure. It was also a marketing technique luring viewers to cinemas by bombarding them with daring posters and stills reproduced in the press and in front of movie theaters. My article will discuss and explain the ways of presenting female nudity in terms of these economic and political tasks.
Filmowiec nie może działać wyłącznie lokalnie. Z Krzysztofem Zanussim o współpracy z kinematografią niemiecką rozmawia Ewa Ciszewska
Authors: Zanussi Krzysztof , Ciszewska Ewa
Published: January 2019

The paper presents an interview with Krzysztof Zanussi (born 17 June 1939), one of the most renowned award-winning Polish film directors. Some of his numerous films for television and cinema have been made in co-operation with German producers, including Manfred Durniok. His film Roads in the Night (Wege in der Nacht, 1979) was presented in 1980 in Cannes as part of the section “Un certain regard”. In Germany, Zanussi filmed not only some of his own screenplays, such as Imperative (Imperativ, 1982 – Special Jury Prize at the Venice International Film Festival in 1982), but also adaptations of Polish and German literature, for example House of Women (Haus der Frauen, 1977) based on a play by Zofia Nałkowska and Bluebeard (Blaubart, 1983) based on a novel by Max Frisch. In addition to those productions, he concurrently made films in Poland. Director of the TOR Film Studio since 1979. He produced films by such directors as Krzysztof Kieślowski and Agnieszka Holland. He currently works on a feature film entitled Ether.
Biased receptor functionality versus biased agonism in G-protein-coupled receptors
Authors: Franco Rafael , Aguinaga David , Jiménez Jasmina , Lillo Jaume , Martínez-Pinilla Eva , Navarro Gemma
Published: January 2019

Functional selectivity is a property of G-protein-coupled receptors (GPCRs) by which activation by different agonists leads to different signal transduction mechanisms. This phenomenon is also known as biased agonism and has attracted the interest of drug discovery programs in both academy and industry. This relatively recent concept has raised concerns as to the validity and real translational value of the results showing bias; firstly biased agonism may vary significantly depending on the cell type and the experimental constraints, secondly the conformational landscape that leads to biased agonism has not been defined. Remarkably, GPCRs may lead to differential signaling even when a single agonist is used. Here we present a concept that constitutes a biochemical property of GPCRs that may be underscored just using one agonist, preferably the endogenous agonist. “Biased receptor functionality” is proposed to describe this effect with examples based on receptor heteromerization and alternative splicing. Examples of regulation of final agonist-induced outputs based on interaction with β-arrestins or calcium sensors are also provided. Each of the functional GPCR units (which are finite in number) has a specific conformation. Binding of agonist to a specific conformation, i.e. GPCR activation, is sensitive to the kinetics of the agonist-receptor interactions. All these players are involved in the contrasting outputs obtained when different agonists are assayed.
There’s No Place Like Home: Investors’ Home Bias in Germany, 1898-1934
Authors: Neumayer Andreas
Published: January 2019

This article studies investors’ expectations and investment decisions in regional stock exchanges in Germany from 1898 to 1934. Investments in stocks are particularly interesting, because research has identified a gap between model predictions of individual investment behaviour and actual investment behaviour. So far there is little information about individual investors or their characteristics in historical periods. To improve the interpretation of investors’ stock market behaviour, I look at investment behaviour and influences on that behaviour over time. I examine data on investors’ characteristics to understand local investment biases using data from regional stock exchanges in Germany from 1898-1934. The statistical analysis first indicates that local investment was clearly important during this period. Then, challenging these findings and analysing different sub-samples, it is suggested that investors’ home bias is potentially overestimated. Previous studies, which found evidence of local investment biases in Germany have presumably overestimated this effect.
Fictional Expectations and the Global Media in the Greek Debt Crisis: A Topic Modeling Approach
Authors: Daniel Volker , Neubert Magnus , Orban Agnes
Published: January 2019

We study the role of global media during the Greek debt crisis and relate it to the transmission of events on financial actors’ expectations. To identify news coverage about the Greek debt crisis, we apply topic modeling to a newly compiled dataset of over 430,000 articles from The International New York Times and Financial Times from 2009 to 2015. We identify a Greek debt crisis topic and relate it to events concerning Greece during this time period. Our finding is that events are only relevant for financial markets when they are covered in the media, whereas events without media coverage have no effect. News coverage without immediate events is equally irrelevant for financial markets.
Perceived barriers to diabetes management at home: a qualitative study
Authors: Açıl Dilay , Bahar Zuhal
Published: January 2019

Background

Diabetes is a complex and progressive disease and its treatment requires self-management strategies specific for each patient. The aim of the study was to determine perceived barriers to diabetes management at home in type II diabetes patients.

Materials and methods

Inclusion criteria of this phenomenological study included living in İzmir and a diagnosis for the last 1 year; 15 patients with diabetes participated the study. A semi-structured interview form based on Health Belief Model created by researchers with experts opinion, was used at in-depth face-to-face interviews. Data were analyzed with content analysis. Ethical and hospital approval was obtained. Participation of individuals is based on volunteerism; written informed consent from patients who accepted the study.

Results

Perceived barriers to fulfilling home care needs and sustaining behavior of diabetes management included six themes, i.e. insufficient knowledge of diabetes, inability to accept diabetes, non-adherence to diabetes and exercise, problems with health care services, fear and effects of the family and the society and relevant subthemes.

Conclusion

These findings about the barriers of the patients should provide guidance for patient specific nursing interventions.
Synthesis of 2,6-dimethoxy-9-phenyl-1H-phenalen-1-one and structural revision of the benzoindenone from Eichhornia crassipes
Authors: Li Xiaowan , Si Tongxu , Ku Chuenfai , Zhang Hongjie , Wang Mingzhong , Chan Albert S.C.
Published: January 2019

The total synthesis of the natural phytoalexin 2,6-dimethoxy-9-phenyl-1H-phenalen-1-one (3) isolated from Eichhornia crassipes was accomplished in seven steps. The synthetic strategy included a Friedel–Crafts acylation and a Jacobsen–Katsuki epoxidation as the key reactions to obtain the target compound. Based on a comparison of the NMR data and a crystal structure of 3, the previously proposed structure of 2,5-dimethoxy-4-phenyl-benzoindenone (2) isolated from the same plant has been revised.
Princípios Dos Cuidados Paliativos E Luto: Descrição Da Experiência Do Projeto De Extensão No Curso De Medicina
Authors: Guirro Ursula Bueno do Prado , Santos Lívia Martins , Moares Atamai Caetano , Leyton Thales Matzkeit , Romano Ricardo , Silva Lucas Gabriel da
Published: January 2019

O projeto de extensão Princípios dos Cuidados Paliativos e Luto da Universidade Federal do Paraná contou com a participação de 20 alunos, alcançou 48 pacientes e seus múltiplos familiares e amigos, envolveu uma médica docente, duas médicas assistentes e incontáveis profissionais e residentes do Setor de Cuidados Paliativos. A iniciativa visava a formação objetiva e subjetiva em cuidados paliativos dos alunos do curso de medicina. Para isso foram desenvolvidas atividades de capacitação teórica, visitas aos pacientes, encontros presenciais e produção de textos. O resultado das atividades foi considerado positivo na perspectiva dos alunos. O projeto de extensão com foco em Cuidados Paliativos pode ser considerado experiência de ensino e aprendizagem satisfatória na graduação médica, e possivelmente em outras áreas da saúde, em que é possível ensinar e vivenciar humanização, empatia, compaixão e cuidados paliativos.
A Comprehensive Examination of Narcissists’ Self-Perceived and Actual Socioemotional Cognition Ability
Authors: Mota Simon , Leckelt Marius , Geukes Katharina , Nestler Steffen , Humberg Sarah , Schröder-Abé Michela , Schmukle Stefan C. , Back Mitja D.
Published: January 2019

Narcissists are assumed to lack the motivation and ability to share and understand the mental states of others. Prior empirical research, however, has yielded inconclusive findings and has differed with respect to the specific aspects of narcissism and socioemotional cognition that have been examined. Here, we propose a differentiated facet approach that can be applied across research traditions and that distinguishes between facets of narcissism (agentic vs. antagonistic) on the one hand, and facets of socioemotional cognition ability (SECA; self-perceived vs. actual) on the other. Using five nonclinical samples in two studies (total N = 602), we investigated the effect of facets of grandiose narcissism on aspects of socioemotional cognition across measures of affective and cognitive empathy, Theory of Mind, and emotional intelligence, while also controlling for general reasoning ability. Across both studies, agentic facets of narcissism were found to be positively related to perceived SECA, whereas antagonistic facets of narcissism were found to be negatively related to perceived SECA. However, both narcissism facets were negatively related to actual SECA. Exploratory condition-based regression analyses further showed that agentic narcissists had a higher directed discrepancy between perceived and actual SECA: They self-enhanced their socio-emotional capacities. Implications of these results for the multifaceted theoretical understanding of the narcissism-SECA link are discussed.
A Demonstration of the Collaborative Replication and Education Project: Replication Attempts of the Red-Romance Effect
Authors: Wagge Jordan R. , Baciu Cristina , Banas Kasia , Nadler Joel T. , Schwarz Sascha , Weisberg Yanna , IJzerman Hans , Legate Nicole , Grahe Jon
Published: January 2019

The present article reports the results of a meta-analysis of nine student replication projects of Elliot et al.’s (2010) findings from Experiment 3, that women were more attracted to photographs of men with red borders (total n = 640). The eight student projects were part of the Collaborative Replication and Education Project (CREP; https://osf.io/wfc6u/), a research crowdsourcing project for undergraduate students. All replications were reviewed by experts to ensure high quality data, and were pre-registered prior to data collection. Results of this meta-analysis showed no effect of red on attractiveness ratings for either perceived attractiveness (mean ratings difference = –0.07, 95% CI [–0.31, 0.16]) or sexual attractiveness (mean ratings difference = –0.06, 95% CI [–0.36, 0.24]); this null result held with and without Elliot et al.’s (2010) data included in analyses. Exploratory analyses examining whether being in a relationship moderated the effect of color on attractiveness ratings also produced null results.
Punishing Homelessness
Authors: Rankin Sara K.
Published: January 2019

Homelessness is punishing to those who experience it, not just from the inherent and protracted trauma of living exposed on the street, but also due to widespread and pervasive laws that punish people for being homeless. People experiencing homelessness, particularly chronic homelessness, often lack reasonable alternatives to living in public. Yet cities throughout the country are increasingly enacting and enforcing laws that punish the conduct of necessary, life-sustaining activities in public, even when many people have no other option. These laws are frequently challenged in court and often struck down as unconstitutional. But legally sound, cost-effective, and non-punitive alternatives to ending chronic homelessness exist. This article exposes some of the problems with criminalization laws, not only for people experiencing homelessness, but also for the broader community. It discusses how current approaches often make chronic homelessness worse and explains why non-punitive alternatives, especially Housing First and permanent supportive housing, are the most cost-effective means of addressing chronic homelessness. Ultimately, this article urges cities and their constituents to stop punishing homelessness and instead to start solving it.
Metformin improves ovarian insulin signaling alterations caused by fetal programming
Authors: Heber María Florencia , Ferreira Silvana Rocío , Abruzzese Giselle Adriana , Trinidad Raíces , Pignataro Omar P , Vega Margarita , Motta Alicia B
Published: January 2019

Insulin resistance is the decreased ability of insulin to mediate metabolic actions. In the ovary, insulin controls ovulation and oocyte quality. Alterations in ovarian insulin signaling pathway could compromise ovarian physiology. Here, we aimed to investigate the effects of fetal programming on ovarian insulin signaling and evaluate the effect of metformin treatment. Pregnant rats were hyperandrogenized with testosterone and female offspring born to those dams were employed; at adulthood, prenatally hyperandrogenized (PH) offspring presented two phenotypes: irregular ovulatory (PHiov) and anovulatory (PHanov). Half of each group was orally treated with metformin. Metformin treatment improved the estrous cyclicity in both PH groups. Both PH groups showed low mRNA levels ofIr,Irs1andGlut4.Irs2was decreased only in PHanov. Metformin upregulated the mRNA levels of some of the mediators studied. Protein expression of IR, IRS1/2 and GLUT4 was decreased in both PH groups. In PHiov, metformin restored the expression of all the mediators, whereas in PHanov, metformin restored only that of IR and IRS1/2. IRS1 phosphorylation was measured in tyrosine residues, which activates the pathway, and in serine residues, which impairs insulin action. PHiov presented high IRS1 phosphorylation on tyrosine and serine residues, whereas PHanov showed high serine phosphorylation and low tyrosine phosphorylation. Metformin treatment lowered serine phosphorylation only in PHanov rats. Our results suggest that PHanov rats have a defective insulin action, partially restored with metformin. PHiov rats had less severe alterations, and metformin treatment was more effective in this phenotype.
Communism as a Spiritual Attack on Man
Authors: Zwoliński Andrzej
Published: January 2019

Marxist ideology, and later the practice of the communist state, denied the essential goals of education, making it an important tool for indoctrination. Man ceased to be the highest value, and was replaced by other values that were lower than him.The communist program of raising children and youth in atheism, without God, was an attack on all believers, because it impacted the future of any religion in Russia.The pontificate of John Paul II, the first Pope from a communist country, was important in determining the threat of Marxism. In the encyclical „Laborem Exercens” the Pope stated that “by the use of various kinds of influence, including revolutionary pressure, it aims to win a monopoly of power in each society.” (LE, 11). The fundamental assessment of Marxism was made by John Paul II in response to social issues posed by the so-called theology of liberation. This power reaches deep and is vast, because it affects the whole person, in all dimensions of his existence.
The Personalist Vision of Marriage in the Context of its Contemporary Depreciation
Authors: Krępa Magdalena
Published: January 2019

This paper presents the personalist vision of marriage referring mostly to Christian teaching on marriage and family. The post-modern society highlights a very critical assessment of the institution of marriage, supporting an individual rather than marital life. In such a situation the Catholic teaching on marriage, and ethos of marriage, is more and more challenged even by Christians, especially in the area of moral decision and life practice. In response to post-modern challenges, Christian personalism refers to the truth about the vocation of man to fulfil their humanity in corporality-determined sexuality. It is not only about anatomic differences but about a different manner of being man in many spheres. Christian reflection, unchangeable as to the assessment of the character of the relationship between a man and a woman, first and foremost refers to a thesis about both the distinctness and complementarity of sexes, embedded in the very human nature. Christian teaching identifies marital love only with the form of the commitment of the person who loves, in their own dynamics, to the good of the person loved. Complete love is directed towards a physical, mental and spiritual union with the loved person and develops from sensuality, through the mental and cultural sphere, to the spiritual domain. A Catholic apprehension of marriage does not question its natural character but defends it, and at the same time shows a radical change that takes place between a man and a woman through the sacramental virtue. Marriage is a deep union and covenant based on love rooted in God remaining the source of Love.
Consequences of Childhood Sexual Abuse for Intimate Couple Relationship according to Relational Marital Therapy
Authors: Jerebic Sara , Jerebic Drago
Published: January 2019

Childhood sexual abuse is a traumatic experience, the consequences of which are numerous in adult intimate relationships. Couples often have problems in maintaining their relationships and frequently face problems in their sexual life. Because of the consequences that they experience and which they usually do not attribute to past trauma, couples increasingly seek therapeutic help. A safe therapeutic relationship enables the formation of new neural connections and a change in relational structures. Identifying and understanding the consequences of sexual abuse with elements of dual awareness is essential for the partnership and healing of both partners. The purpose of the article is to deepen the understanding of the consequences of childhood sexual abuse for couple relationships according to the Relational Marital Therapy paradigm.
Anthropology of the evangelical counsels in the school of St. Benedict of Nursia
Authors: Tupikowski Jerzy
Published: January 2019

Man is someone real and as such he is immersed in a world that is a task set to him as a person. Therefore, the whole world, as entirely coming from God, and entirely assigned to Him, is constantly bursting with its natural truth and good and, consequently, also beauty. This is an important perspective, both in the order of nature and in the order of grace, also because the synthesis and fulfilment of all values (perfections), which is personal fullness – holiness, is the ultimate reference of the human person to the Person of God. However, this perspective becomes comprehensible only in the field of the realism of the human person’s truth, goodness and beauty, related to their perfect Source, and therefore to the Truth, Goodness and Beauty of the Person of God Himself.In this sense, it can be said that God is the End of all perfections. Holiness itself is thus a specific peak of the elevation of human potentialities to a higher level of being. „Holiness, through the elevation of truth, goodness and beauty to the supernatural level, can fulfil the potential of human nature – reason and will, to their limits; and this fulfilment, in Christian thought, can only take place in visio beatifica, to which this life here and now is supposed to prepare us”. Let us add that the understanding and implementation of evangelical counsels: chastity, poverty and obedience, serve this growth in a particular way. The counsels are the evangelical factor stimulating and strengthening the work of the intellect and free will.
Kościół o możliwościach techniki
Authors: Zwoliński Andrzej
Published: January 2019

Kościół o możliwościach techniki. W kontekście rozwoju nowych technologii Kościół wskazuje na potrzebę odkrywania prawdy o człowieku i jego roli w świecie technologii. W analizach techniki współczesnej już dawno rozróżniano tzw. technikę służebną i technikę prometejską. W tym ujęciu techniki zawiera się pewna dwoistość jej rozumienia. W nowych rozwiązaniach technicznych może bowiem kryć się zamach na miejsce człowieka w świecie, bunt przeciw prawom Bożym albo też służebne korzystanie z darów Bożych, zgodnie z zamysłem i planem Boga. Krytyka transhumanizmu sprowadza się do zastrzeżeń co do możliwości osiągnięcia wyznaczonych celów oraz zastrzeżeń natury etycznej. Są to zarzuty natury ogólnej, wysuwane od dawna wobec spontanicznego rozwoju techniki i nowych technologii.
Rola cudu w apologetyce przed II soborem watykańskim. Refleksja na podstawie analizy ówczesnych podręczników akademickich
Authors: Plata Łukasz
Published: January 2019

W niniejszym artykule autor podjął refleksję nad tym, jaka była rola cudu w wykładzie podręcznikowym apologetyki przed Vaticanum II. Szukając odpowiedzi na to pytanie, najpierw przedstawił nauczanie I Soboru Watykańskiego na temat cudu i jego roli. Następnie poddał analizie kilka polskojęzycznych podręczników akademickich do apologetyki, jakie pojawiły się przed II soborem watykańskim, aby zbadać w nich funkcję cudu w relacji do Objawienia.
IL-34–Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice
Authors: Wada Yukihiro , Gonzalez-Sanchez Hilda M. , Weinmann-Menke Julia , Iwata Yasunori , Ajay Amrendra K. , Meineck Myriam , Kelley Vicki R.
Published: January 2019

Significance Statement

Macrophages and autoantibodies play a central role in the pathology of lupus nephritis in patients with lupus and in the MRL-Faslpr
mouse model. The authors demonstrate that IL-34 and its two receptors, cFMS and PTPRZ, are upregulated in the kidney with advancing nephritis in MRL-Faslpr
mice. Genetically deleting IL-34 in these mice suppresses nephritis and the systemic illness via macrophage- and autoantibody-mediated mechanisms within and outside of the kidney. The authors also found that patients with lupus nephritis have elevated IL-34 in serum and urine; intrarenal and systemic expression of IL-34, cFMS, and PTPRZ similar to that displayed in MRL-Faslpr
mice; and IL-34 expression that correlates with histopathologic index of disease activity. These findings suggest that IL-34 is a promising novel therapeutic target for patients with lupus nephritis.

Background

In people with SLE and in the MRL-Faslpr
lupus mouse model, macrophages and autoantibodies are central to lupus nephritis. IL-34 mediates macrophage survival and proliferation, is expressed by tubular epithelial cells (TECs), and binds to the cFMS receptor on macrophages and to a newly identified second receptor, PTPRZ.

Methods

To investigate whether IL-34–dependent intrarenal and systemic mechanisms promote lupus nephritis, we compared lupus nephritis and systemic illness in MRL-Faslpr
mice expressing IL-34 and IL-34 knockout (KO) MRL-Faslpr
mice. We also assessed expression of IL-34 and the cFMS and PTPRZ receptors in patients with lupus nephritis.

Results

Intrarenal IL-34 and its two receptors increase during lupus nephritis in MRL-Faslpr
mice. In knockout mice lacking IL-34, nephritis and systemic illness are suppressed. IL-34 fosters intrarenal macrophage accumulation via monocyte proliferation in bone marrow (which increases circulating monocytes that are recruited by chemokines into the kidney) and via intrarenal macrophage proliferation. This accumulation leads to macrophage-mediated TEC apoptosis. We also found suppression of circulating autoantibodies and glomerular antibody deposits in the knockout mice. This is consistent with fewer activated and proliferating intrarenal and splenic B cells in mice lacking IL-34, and with our novel discovery that PTPRZ is expressed by macrophages, B and T cells. These findings appear translatable to human patients with lupus nephritis, whose expression of IL-34, cFMS, and PTPRZ is similar to that seen in the MRL-Faslpr
lupus mouse model. Moreover, expression of IL-34 in TECs correlates with disease activity.

Conclusions

IL-34 is a promising novel therapeutic target for patients with lupus nephritis.
Economic Performance of BRICS Economies: An Analysis of Pre and Post BRICS Era
Authors: Dhanasekaran P. , Sumathy M.
Published: January 2019

This paper intends to analyse the impact of some selected macroeconomic factors on the economies of BRICS nations during the pre and post BRICS era. The analysis done based on the paired sample t-test found a significant impact on the imports, exports, GDP, REER and GCF of BRICS economies during the pre and post BRICS era. The impact is very significant in India as well. The study concluded that though these economies have many challenges to sustain and maintain the trend. FDI will facilitate these economies to enhance large scale production, employment and sustainability.
Login to UA HPC v2
Authors: Youens-Clark Ken , L Hurwitz Bonnie
Published: January 2019

This describes setting up ssh keys and configuration to avoid having to useyour NetID+ 2-factor authentication every time you log into the HPC. Windows users will needto install a free Unix-like environment that provides a terminal so as to avoid using an ssh client like Putty (for example: Cygwin (http://www.cygwin.com)). Cygwin users must be sure to install the 'ssh' tools which are not installed by default.