bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of COVID-19 on the Comprehensive Resilience of Rural Areas—A Case Study of Jilin Province of China
Authors: Yu Jie , Zhang Jiquan , Zhou Miaolei , Cai Weiying
Published: February 2023

It is of practical significance for rural revitalization to clarify the gap in resilience development among different rural areas and improve the ability to cope with external interference. Combined with the strategic policy of rural revitalization in China, the evaluation index system of rural comprehensive resilience was constructed from the five dimensions of productive resilience, ecological resilience, social resilience, institutional resilience, and economic resilience. The advantages and disadvantages of rural development are determined based on a quantitative evaluation of the comprehensive resilience of rural development. This could provide a reference for decision making in rural development. This study uses the rural statistical data of nine cities (prefectures) in Jilin Province in 2019 and 2020 as an example as well as the entropy weight method to evaluate the impact of COVID-19 on rural resilience development. The results showed that the pandemic situation has an obvious impact on rural economic resilience; rural areas with high ecological resilience have a strong ability to cope with the panidemic situation; and rural areas with excellent ecological environment resources have strong comprehensive resilience.
Potentials from the Polynomial Solutions of the Confluent Heun Equation
Authors: Lévai Géza
Published: February 2023

Polynomial solutions of the confluent Heun differential equation (CHE) are derived by identifying conditions under which the infinite power series expansions around the z=0 singular point can be terminated. Assuming a specific structure of the expansion coefficients, these conditions lead to four non-trivial polynomials that can be expressed as special cases of the confluent Heun function Hc(p,β,γ,δ,σ;z). One of these recovers the generalized Laguerre polynomials LN(α), and another one the rationally extended X1 type Laguerre polynomials L^N(α). The two remaining solutions represent previously unknown polynomials that do not form an orthogonal set and exhibit features characteristic of semi-classical orthogonal polynomials. A standard method of generating exactly solvable potentials in the one-dimensional Schrödinger equation is applied to the CHE, and all known potentials with solutions expressed in terms of the generalized Laguerre polynomials within, or outside the Natanzon confluent potential class, are recovered. It is also found that the potentials generated from the two new polynomial systems necessarily depend on the N quantum number. General considerations on the application of the Heun type differential differential equations within the present framework are also discussed.
Equivalent Conditions of the Reverse Hardy-Type Integral Inequalities
Authors: Rassias Michael Th. , Yang Bicheng , Raigorodskii Andrei
Published: February 2023

Hardy-type integral inequalities play a prominent role in the study of analytic inequalities, which are essential in mathematical analysis and its various applications, such as in the study of symmetry and asymmetry phenomena. In this paper, employing methods of real analysis and using weight functions, we investigate some equivalent conditions of two kinds of reverse Hardy-type integral inequalities with a particular non-homogeneous kernel. A few equivalent conditions of two kinds of reverse Hardy-type integral inequalities with a particular homogeneous kernel are deduced in the form of applications.
The Meaning of “Structure” in Systems Thinking
Authors: Monat Jamie P. , Gannon Thomas F.
Published: February 2023

“Systemic structure” is an oft-used term in Systems Thinking. However, different authors use different, sometimes conflicting definitions of “systemic structure,” many of which are nebulous, and therefore its meaning is not clear. In this paper, we review the various definitions and interpretations and develop a logical, practical definition that may be applied to develop a deep understanding of system behavior: in Systems Thinking, “structure” is the cause-and-effect manner in which system components interrelate to yield system behavior; and the rules, laws, protocols, procedures, policies, and incentives/rewards that govern those interactions.
Exploring Carsharing Diffusion Challenges through Systems Thinking and Causal Loop Diagrams
Authors: Shams Esfandabadi Zahra , Ranjbari Meisam
Published: February 2023

The diffusion of carsharing in cities can potentially support the transition towards a sustainable mobility system and help build a circular economy. Since urban transportation is a complex system due to the involvement of various stakeholders, including travelers, suppliers, manufacturers, and the government, a holistic approach based on systems thinking is essential to capture this complexity and its causalities. In this regard, the current research aims at identifying cause-and-effect relationships in the diffusion of carsharing services within the urban transport systems. To do so, a causal loop diagram (CLD) is developed to identify and capture the causalities of carsharing adoption. On this basis, the main four players within the carsharing domain in urban transportation were scrutinized and their causes and effects were visualized, including (i) the characteristics, behavior, and dynamics of the society population; (ii) transportation system and urban planning; (iii) the car manufacturing industry; and (iv) environmental pollution. The developed CLD can support decision-makers in the field of urban transport to gain a holistic and systemic approach to analyzing the issues within the transport sector due to their complexity. Moreover, they can help regulators and policymakers in intensifying the diffusion of more sustainable modes of transport by highlighting the role of population, car manufacturing, the transportation system, and environmental pollution.
Optimal Location of the Active Thermal Insulation Layer in the Building Envelope
Authors: Król Barbara , Kupiec Krzysztof
Published: February 2023

One of the modern methods of protecting against building heat losses is active thermal insulation (ATI). In winter conditions, ATI works by supplying heat into the envelope, which increases the temperature in the ATI layer. A low-temperature renewable energy medium feeds the active insulation layer directly, e.g., through solar or geothermal energy. A model for heat transfer through the building envelope with an ATI layer was developed. The numerical simulations verified the simplifying assumptions in the model. A relationship was derived to determine the optimal location of the ATI layer in the envelope. The objective function of the summed costs of the thermal energy supplied to the internal space and the envelope was assumed. We took into account the fact that the unit price of energy supplied to the ATI layer is lower than the price of the energy supplied to the internal space. Based on the results of the measurements carried out in a building facility with the ATI layer installed, the actual savings effects due to the ATI layer were compared to the calculated values.
Insights into the Understanding of Adsorption Behaviors of Legacy and Emerging Per- and Polyfluoroalkyl Substances (PFASs) on Various Anion-Exchange Resins
Authors: Tan Hong-Ming , Pan Chang-Gui , Yin Chao , Yu Kefu
Published: February 2023

Per- and polyfluoroalkyl substances (PFASs) have received extensive attention due to their various harmful effects. In this study, the adsorptive removal of 10 legacy and emerging PFASs by four anion-exchange resins (including gel and macroreticular resins) were systematically investigated. Our results showed that the capacities of resins absorbing PFASs were ranked in the following order: gel strong base HPR4700 (297~300 μg/g) ≈ macroreticular strong base S6368 (294~300 μg/g) ≈ macroreticular weak base A111S (289~300 μg/g) > gel weak base WA10 (233~297 μg/g). Adsorption kinetic results indicated that the adsorption process might involve chemical and Henry regime adsorption or reaction control. Intraparticle diffusion was probably the major removal step. Co-existing fulvic acid (0.5, 1, 5 mg/L) and inorganic anions (5 mg/L of sulfate, carbonate, bicarbonate) would hinder the PFAS removal by resins with WA10 showing the highest inhibition rate of 17% and 71%, respectively. The adsorption capacities of PFBA decreased from 233 μg/g to 194 μg/g, and from 233 μg/g to 67 μg/g in the presence of fulvic acid and inorganic anions, respectively. PFASs were more easily removed by HPR4700, S6368, and A111S under neutral and alkaline environment. Moreover, WA10 was not able to remove PFASs under an alkaline medium. This study offered theoretical support for removing PFASs from aqueous phases with various resins.
Paenibacillus polymyxa Antagonism towards Fusarium: Identification and Optimisation of Antibiotic Production
Authors: Ran Junjian , Wu Youzhi , Zhang Bo , Su Yiwei , Lu Ninghai , Li Yongchao , Liang Xinhong , Zhou Haixu , Shi Jianrong
Published: February 2023

An antibiotic produced by Paenibacillus polymyxa 7F1 was studied. The 7F1 strain was isolated from the rhizosphere of a wheat field. Response surface methodology was used to optimize the physicochemical parameters. The strain showed broad-spectrum activity against several plant pathogens. Identification of the strain was realized based on 16s rRNA gene and gyrB gene sequencing. The antibiotic was optimized by one-factor-at-a-time (OFAT) and response surface methodology (RSM) approaches. The suitable antibiotic production conditions were optimized using the one-factor-at-a-time method. The individual and interaction effects of three independent variables: culture temperature, initial pH, and culture time, were optimized by Box-Behnken design. The 16SrRNA gene sequence (1239 nucleotides) and gyrB gene (1111 nucleotides) were determined for strain 7F1 and shared the highest identities to those of Paenibacillus polymyxa. The results showed the optimal fermentation conditions for antibiotics produced by Paenibacillus polymyxa 7F1 were a culture temperature of 38 °C, initial pH of 8.0, and culture time of 8 h. The antibiotics produced by Paenibacillus polymyxa 7F1 include lipopeptides such as iturin A and surfactin. The results provide a theoretical basis for the development of bacteriostatic biological agents and the control of mycotoxins.
Gauge Couplings Evolution from the Standard Model, through Pati–Salam Theory, into E8 Unification of Families and Forces
Authors: Aranda Alfredo , Anda Francisco J. de , Morais António P. , Pasechnik Roman
Published: February 2023

We explore the potential of ultimate unification of the Standard Model matter and gauge sectors into a single E8 superfield in ten dimensions via an intermediate Pati–Salam gauge theory. Through a consistent realisation of a T6/(Z6×Z2×Z2) orbifolding procedure and renormalisation group evolution of gauge couplings, we establish several novel benchmark scenarios for New Physics that are worth further phenomenological exploration.
Bandhead Energies of npp/pnn Three-Quasiparticle Quadruplets
Authors: Kumar Sushil , Kaur Manpreet , Singh Sukhjeet , Singh Jagjit , Jain A. K.
Published: February 2023

Semi-empirical frameworks are widely used in calculating the bandhead energies of three-quasiparticle (3qp) configurations observed in well-deformed odd-A nuclei. In the present study, our aim is to improve the previous version of the semi-empirical model [Physical Review C. 1992, 45(6), 3013]. This is achieved by incorporating the ignored vital contributions owing to the irrotational motion of valance protons/neutrons, diagonal components of particle–particle coupling (ppc), and rotor–particle coupling (rpc) terms. We tested the validity of the improved version of the model by calculating the bandhead energies of twelve 3qp npp/pnn quadruplets observed in 163Er, 171,175,177Lu, 177Ta, and 183Re nuclides. Our new results show better agreement with the experimental data indicating the importance of newly added terms. We strongly expect that the present version of the model will provide support to future experimental campaigns for making configuration assignments to the newly observed 3qp bands and also in the identification of exact Nilsson’s configurations of 3qp quadruplets where experimental data that differentiate among the competing configuration are scarce.
Multi-Periodicity of High-Frequency Type III Bursts as a Signature of the Fragmented Magnetic Reconnection
Authors: Karlický Marian , Rybák Ján
Published: February 2023

Using the radio spectra of the 2 April 2022 eruptive flare, we analyze a group of highfrequency type III bursts by our new wavelet method. In this analysis, we found a multi-periodicity of these bursts that is interpreted by the electron beams accelerated in the fragmented magnetic reconnection in the rising magnetic rope. We propose that each period in these type III bursts is a result of the periodic interaction of sub-ropes formed in the rising magnetic rope. In each interaction, the period depends on the diameter of interacting sub-ropes and local Alfvén velocity. This interpretation is supported by detection of the specific EUV structure which was, according to our knowledge, observed for the first time. All proposed processes occur in the rising magnetic rope. Thus, this flare deviates from the standard flare model, where the main magnetic reconnection is located below the rising magnetic rope.
A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism
Authors: Zhang Qun , Zhang Fan , Chang Xiaoran , Hu Junying , Zhang Zhiyuan , Cui Xuyuan , Zheng Xuebo , Wang Xinping
Published: February 2023

As the first caprine enterovirus identified from goat herds characterized by severe diarrhea with a high morbidity and mortality rate, the underlying pathogenesis and tissue tropism for CEV-JL14 remains largely unknown. Here, we reported the establishment of a neonatal murine model for caprine enterovirus and the unveiling of the tissue tropism and underlying pathogenesis for CEV-JL14 enterovirus. Susceptible murine strains, the infective dose, the infective routes, viral loads, and tissue tropism for CEV-JL14 infection were determined. The findings showed that ICR mice were susceptible to CEV-JL14 infection via all infection routes. Tissue viral load analysis showed that CEV-JL14 was detected in almost all tissues including the heart, liver, spleen, lung, kidney, intestine, brain, and muscle, with significantly higher viral loads in the heart, liver, lung, kidney, and intestine. These results revealed the pattern of viral load and tropism for CEV-JL14 and provided a model system for elucidating the pathogenesis of CEV-JL14 viruses.
Deubiquitinating Enzyme Inhibitors Block Chikungunya Virus Replication
Authors: López Lady S. , Calvo Eliana P. , Castellanos Jaime E.
Published: February 2023

Ubiquitination and deubiquitination processes are widely involved in modulating the function, activity, localization, and stability of multiple cellular proteins regulating almost every aspect of cellular function. Several virus families have been shown to exploit the cellular ubiquitin-conjugating system to achieve a productive infection: enter the cell, promote genome replication, or assemble and release viral progeny. In this study, we analyzed the role of deubiquitinating enzymes (DUBs) during chikungunya virus (CHIKV) infection. HEK293T, Vero-E6, and Huh-7 cells were treated with two DUB inhibitors (PR619 or WP1130). Then, infected cells were evaluated by flow cytometry, and viral progeny was quantified using the plaque assay method. The changes in viral proteins and viral RNA were analyzed using Western blotting and RT-qPCR, respectively. Results indicate that treatment with DUB inhibitors impairs CHIKV replication due to significant protein and viral RNA synthesis deregulation. Therefore, DUB activity may be a pharmacological target for blocking CHIKV infection.
Overcoming Suppressive Tumor Microenvironment by Vaccines in Solid Tumor
Authors: Xie Ya-Jia , Liu Wen-Qian , Li Dan , Hou Jin-Cai , Coghi Paolo Saul , Fan Xing-Xing
Published: February 2023

Conventional vaccines are widely used to boost human natural ability to defend against foreign invaders, such as bacteria and viruses. Recently, therapeutic cancer vaccines attracted the most attention for anti-cancer therapy. According to the main components, it can be divided into five types: cell, DNA, RNA, peptide, and virus-based vaccines. They mainly perform through two rationales: (1) it trains the host immune system to protect itself and effectively eradicate cancer cells; (2) these vaccines expose the immune system to molecules associated with cancer that enable the immune system to recognize and destroy cancer cells. In this review, we thoroughly summarized the potential strategies and technologies for developing cancer vaccines, which may provide critical achievements for overcoming the suppressive tumor microenvironment through vaccines in solid tumors.
Immunoinformatics Study: Multi-Epitope Based Vaccine Design from SARS-CoV-2 Spike Glycoprotein
Authors: Umitaibatin Ramadhita , Harisna Azza Hanif , Jauhar Muhammad Miftah , Syaifie Putri Hawa , Arda Adzani Gaisani , Nugroho Dwi Wahyu , Ramadhan Donny , Mardliyati Etik , Shalannanda Wervyan , Anshori Isa
Published: February 2023

The coronavirus disease 2019 outbreak has become a huge challenge in the human sector for the past two years. The coronavirus is capable of mutating at a higher rate than other viruses. Thus, an approach for creating an effective vaccine is still needed to induce antibodies against multiple variants with lower side effects. Currently, there is a lack of research on designing a multiepitope of the COVID-19 spike protein for the Indonesian population with comprehensive immunoinformatic analysis. Therefore, this study aimed to design a multiepitope-based vaccine for the Indonesian population using an immunoinformatic approach. This study was conducted using the SARS-CoV-2 spike glycoprotein sequences from Indonesia that were retrieved from the GISAID database. Three SARS-CoV-2 sequences, with IDs of EIJK-61453, UGM0002, and B.1.1.7 were selected. The CD8+ cytotoxic T-cell lymphocyte (CTL) epitope, CD4+ helper T lymphocyte (HTL) epitope, B-cell epitope, and IFN-γ production were predicted. After modeling the vaccines, molecular docking, molecular dynamics, in silico immune simulations, and plasmid vector design were performed. The designed vaccine is antigenic, non-allergenic, non-toxic, capable of inducing IFN-γ with a population reach of 86.29% in Indonesia, and has good stability during molecular dynamics and immune simulation. Hence, this vaccine model is recommended to be investigated for further study.
Safety Monitoring of mRNA COVID-19 Vaccines in Children Aged 5 to 11 Years by Using EudraVigilance Pharmacovigilance Database: The CoVaxChild Study
Authors: Zinzi Alessia , Gaio Mario , Liguori Valerio , Ruggiero Rosanna , Tesorone Marina , Rossi Francesco , Rafaniello Concetta , Capuano Annalisa
Published: February 2023

Although the safety profiles of mRNA COVID-19 vaccines (mRNA-1273 and BNT162b2) were evaluated in pre-authorization clinical trials, real-world data allow us to better define their benefit/risk ratio in the paediatric population. The current study aimed to evaluate the safety profiles of mRNA COVID-19 vaccines in children by analysing the pharmacovigilance data of the European spontaneous reporting system database EudraVigilance (EV) in the period from 1 January 2021, to 1 October 2022. During our study period, overall 4838 ICSRs related to mRNA COVID-19 vaccines referring to 5–11-year-old subjects were retrieved from EV, of which 96.9% were related to BNT162b2 and 49.3% were related to males. A total of 12,751 Adverse Events Following Immunization (AEFIs) were identified, of which 38.7% were serious. The most frequently reported AEFIs were pyrexia, headache, and vomiting. Only 20 Individual Case Safety Reports (ICSRs) reported Multisystem Inflammatory Syndrome (MIS) as an AEFI, all related to BNT162b2. The majority of MIS cases were females, and six cases were completely resolved at the time of reporting. Our results show a favourable risk–benefit profile for all mRNA COVID-19 vaccines in this paediatric sub-population, supporting their use in children. Considering the peculiarity and fragility of children, continuous safety monitoring of COVID-19 vaccines is required.
Associations of HLA Polymorphisms with Anti-SARS-CoV-2 Spike and Neutralizing Antibody Titers in Japanese Rheumatoid Arthritis Patients Vaccinated with BNT162b2
Authors: Higuchi Takashi , Oka Shomi , Furukawa Hiroshi , Tohma Shigeto
Published: February 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019. Anti-SARS-CoV-2 spike (S) and neutralizing antibodies (Abs) are measured to evaluate the efficacy of vaccines. Human leukocyte antigen (HLA) may be associated with vaccine efficacy. Here, we investigated the association of HLA polymorphisms with the production of anti-SARS-CoV-2 S or neutralizing Abs in vaccinated rheumatoid arthritis (RA) patients in Japan. Genotyping of DRB1 and DQB1 was conducted in 87 Japanese RA patients vaccinated with BNT162b2. Associations of allele or haplotype carrier frequencies with anti-SARS-CoV-2 S or neutralizing Abs were examined. DRB1*12:01 was significantly positively associated with the production of S Ab (p = 0.0225, odds ratio [OR] 6.08, 95% confidence interval [CI] 1.32–28.03). The DQB1*03:01 allele carrier frequency tended to be higher in high responders of S Ab. Allele carrier frequencies of DRB1*15:01 (p = 0.0102, OR 9.26, 95% CI 1.65–52.01) and DQB1*06:02 (p = 0.0373, OR 7.00, 95% CI 1.18–41.36) were higher in responders of neutralizing Ab. Haplotype and two-locus analyses of DRB1 and DQB1 suggested that DRB1 alleles were the primary drivers of these associations. Logistic regression analysis showed associations of these alleles independent of clinical characteristics. Independent associations were found between HLA alleles and anti-SARS-CoV-2 Ab production by vaccinated RA patients.
Arising Concerns of Atypical Manifestations in Patients with Hand, Foot, and Mouth Disease
Authors: Chen Yu , Dai Bowen , Han Shujie , Duan Guangcai , Yang Haiyan , Chen Shuaiyin , Ji Wangquan , Jin Yuefei
Published: February 2023

Hand, foot, and mouth disease (HFMD) is a mild exanthematous, febrile disease, but it also remains a threat to global public health. HFMD is characterized by a brief febrile illness in children and with a typical skin rash of the hand and foot, with or without mouth ulcers. However, the morphology and distribution of vesicles, as well as accompanying symptoms, are varied among atypical HFMD. An upsurge in atypical presentations of HFMD caused by Coxsackievirus A6 (CVA6), including Gianotti–Crosti-like eruptions, eczema coxsackium, petechial/purpuric eruption, and vesiculobullous exanthema, can be difficult to diagnose clinically as it may mimic other severe skin diseases, such as eczema herpeticum, varicella, disseminated zoster, and erythema multiforme major. The recognition of the distinguishing features of atypical HFMD is vital for an accurate and timely diagnosis, as is initiating appropriate laboratory evaluation and supportive care. Clinicians must identify the wide range of cutaneous and mucosal alterations caused by atypical HFMD. A systemic, high-quality overview of atypical HFMD is needed for advances in better strategies for clinical diagnosis and treatment. Hence, this review is aimed at summarizing the available data on clinical investigations and differential diagnostics to provide a scientific guide for the timely diagnosis of HFMD for preventing serious complications.
Preparation and Identification of a Monoclonal Antibody against the Pseudorabies Virus gE Glycoprotein through a Novel Strategy
Authors: Guo Zhenyang , Zhang Siyu , Xu Hu , Li Wansheng , Li Chao , Zhao Jing , Gong Bangjun , Sun Qi , Xiang Lirun , Zhao Hongyuan , Wang Qian , Zhou Guohui , Tang Yandong , An Tongqing , Cai Xuehui , Tian Zhijun , Zhang Hongliang , Peng Jinmei
Published: February 2023

Since 2011, pseudorabies virus (PRV) has recurred in several vaccinated pig farms in China. PRV variants with high virulence were found to be the main cause of the outbreaks. In the face of the PRV epidemic, detection of the wild strain is as important as vaccine immunization, so we hoped to achieve differential diagnosis of PRV by obtaining a monoclonal antibody (mAB) that could be used to identify the wild strain. In this study, we used a novel immunization and screening strategy to prepare an mAB and obtained mAB 1H5 against the gE glycoprotein. An immunofluorescence assay (IFA) revealed that this mAB was specific to both classic and variant strains of PRV. Subsequently, we further identified the linear epitopes of B cells recognized using the mAB. The mAB 1H5 bound at 67RRAG70, which is a novel epitope and is conserved in almost all PRV strains. These findings provide novel insight into the structure and function of PRV proteins, the analysis of antigenic epitope characteristics, and the establishment of antigen or antibody detection methods.
Enhancement of Anticancer, Antibacterial, and Acetylcholinesterase Inhibition Activities from Oscillatoria sancta under Starvation Conditions
Authors: Touliabah Hussein E. , Refaay Dina A.
Published: February 2023

The growth response and biological activity of the cyanobacterium Oscillatoria sancta were investigated in starvation conditions. Oscillatoria sancta growth potential was examined on BG11 and Zarrouk’s media. Zarrouk’s medium supported the maximum growth of the test cyanobacterium. Zarrouk’s medium composition was modified by excluding CaCl2·2H2O, NaCl, EDTA (Na), micronutrients, and replacing sodium nitrate with urea. Using Zarrouk’s medium and three different concentrations of modified Zarrouk’s media (Treatments 1–3), the growth response of Oscillatoria sancta (MZ366482) was examined and compared. Zarrouk’s medium and modified Zarrouk’s medium at 12.5% nutrient concentration had non-significant differences in both the dry weight biomass and total protein of Oscillatoria sancta. Oscillatoria sancta crude biomass extracts grown on Zarrouk’s and modified Zarrouk’s media (T3) inhibited human breast cancer, pathogenic bacteria, and acetylcholinesterase activity. Oscillatoria sancta grown on T3 showed the most potency against MDA-MB-231 cells with an IC50 of 165.2 µg mL−1, antibacterial activity only against Bacillus cereus (17.2 mm) and Staphylococcus aureus (15.3 mm), and acetylcholinesterase inhibition activity by 60.7%. Thus, it is advisable to use the 12.5% nutrient concentration of modified Zarrouk’s medium as a reduced-cost medium for mass cultivation of Oscillatoria sancta with potential anticancer, antibacterial diseases, and anti-Alzheimer purposes.
Integration of Distributed Streamflow Measurement Metadata for Improved Water Resource Decision-Making
Authors: Kaiser Kendra E. , Blasch Kyle , Schmitz Steven
Published: February 2023

Streamflow data are critical for monitoring and managing water resources, yet there are significant spatial gaps in our federal monitoring networks with biases toward large perennial rivers. In some cases, streamflow monitoring exists in these spatial gaps, but information about these monitoring locations is challenging to obtain. Here, we present a streamflow catalog for the United States Pacific Northwest that includes current and historical streamflow monitoring location information obtained from 32 organizations (other than the U.S. Geological Survey), which includes 2661 continuous streamflow gaging locations (22% are currently active) and 30,557 discrete streamflow measurements. A stakeholder advisory board with representatives from organizations that operate streamflow monitoring networks identified metadata requirements and provided feedback on the Streamflow Data Catalog user interface. Engagement with the water resources community through this effort highlighted challenges that water professionals face in collecting and managing streamflow data so that data are findable, accessible, interoperable, and reusable (FAIR). Over 60% of the streamflow monitoring locations in the Streamflow Data Catalog are not available online and are thus not findable through web search engines. Providing organizations technical assistance with standard measurement procedures, metadata collection, and web accessibility could substantially increase the availability and utility of streamflow information to water resources communities.
The linear structure of Belarusian type of pigs of Yorkshire breed on base of the analysis of DNA differentiation of microsatellites
Authors:   Republican Unitary Enterprise “The Scientifi c and Practical Center of the National Academy of Sciences of Belarus for Animal Husbandry”, Republic of Belarus, Minsk region, Zhodino, Kazutova Yu. S. , Balnikov A. A. ,   Republican Unitary Enterprise “The Scientifi c and Practical Center of the National Academy of Sciences of Belarus for Animal Husbandry”, Republic of Belarus, Minsk region, Zhodino, Kostomakhin N. M. ,   Federal State Budgetary Educational Institution of Higher Education “Russian State Agrarian University – Moscow Timiryazev Agricultural Academy”, Russia, Moscow, Gridyushko I. F. ,   Republican Unitary Enterprise “The Scientifi c and Practical Center of the National Academy of Sciences of Belarus for Animal Husbandry”, Republic of Belarus, Minsk region, Zhodino
Published: February 2023

The purpose of the research was to study the linear structure of Belarusian breeding type of Yorkshire pigs based on the analysis of DNA differentiation of microsatellites. The genetic diversity and characterizes the linear structure of Belarusian breeding type of Yorkshire breed pigs are bred in the State Enterprise “ZhodinoAgroPlemElita” in the Minsk region and OAO “Selection and Hybrids Center “Zapadny” in the Brest region have been assessed in the paper. The genetic material of 28 boars was selected and their breed belonging was determined based on the analysis of established microsatellites, genetic diff erences between the lines and the degree of heterozygosity of animals in the lines. It has been established that the studied lines were genetically diff erentiated and were characterized by a high level of genetic diversity. Promising breeding boars of breeding lines in Belarusian breeding type of pigs of Yorkshire breed have been identifi ed and selected. When determining the genetic affi liation of boars to the line using the Assignment test, it was found that 12 out of 19 tested boars of four breeding lines confi rmed their pedigree-linear affiliation in the Selection and Hybrids Center “Zapadny” including 8 out of 11 tested boars in Drug 6805 line and two boars each in the Duchess 3962 and Factor 1573 breeding lines. The same trend was noted in the State Enterprise “ZhodinoAgroPlemElita”, where out of the tested 9 animals, 4 boars confi rmed their pedigree-linear affi liation (one each in Drug 6805 line and Dobryi 2313 line, two boars from breeding line No. 1131). The dendograms constructed on the basis of genetic similarity in the population of diff erent breeding lines of Belarusian breeding type of pigs of Yorkshire breed showed the greatest genetic closeness between individual breeding lines. The results obtained can be used in the development of a genetic passport of the breed.
Productive traits of sheep of Prikatun breeding type under the conditions of the Altai Republic
Authors:   Federal State Budgetary Educational Institution of Higher Education “Altai State Agrarian University”, Russia, Altai Territory, Barnaul, Podkorytov N. A. , Rastopshina L. V. ,   Federal State Budgetary Educational Institution of Higher Education “Altai State Agrarian University”, Russia, Altai Territory, Barnaul
Published: February 2023

The main number of sheep in the Russian Federation is currently concentrated in peasant (farmer) and personal farms, where the level of breeding work is often very low. Despite this, there is a huge reserve of mutton production in these categories of farms. The purpose of the work was to study the productive traits of sheep of Prikatun breeding type of Mountain Altai breed under the conditions of peasant (farmer) farms in the Altai Republic. The experimental part of the research was carried out on the basis of the farm “Usoltseva N. A.” in the Ust-Kansky area in the Altai Republic. The object of the study were the mature ewes sheep of Prikatun breeding type of Mountain Altai breed, their off spring aged from birth, 4 and 6 months, before slaughter, as well as carcasses obtained during slaughter. Under the conditions of the Altai Republic with year-round pasture content in sheep of Prikatun breeding type of Mountain Altai breed a complex study of milk productivity and the chemical composition of sheep’s milk was carried out. New data on the eff ect of age, live weight, prolifi cacy, polymastia, off spring sex and morphometric measurements of the udder on the milk production of sheep have been obtained. The infl uence of the level of milk content of sheep of Prikatun breeding type of Mountain Altai breed on the growth, development and meat productivity of lambs has been studied. It was found that lambs received from mothers with high milk capacity had a higher growth rate in all the studied age periods. The young animals of this group were characterized by better meat productivity and as a result had a higher level of profi tability, which amounted to 53,35 %. Taking into account the infl uence of the level of milk production of ewes of Prikatun breeding type on the growth and development of lambs, we recommend that peasant (farmer) farms of the Altai Republic, in order to increase the production of mutton, select ewes for the fi rst 20 days of lactation with a milk yield of at least 21 kg of milk.
Metabolism, productivity and technological properties of milk in cows when using the feed additive BioPrimum dry
Authors:   Federal State Budgetary Educational Institution of Higher Education “Ogarev National Research Mordovian State University”, Russia, Republic of Mordovia, Saransk, Kistina A. A. , Ruin V. A. ,   Federal State Budgetary Educational Institution of Higher Education “Ogarev National Research Mordovian State University”, Russia, Republic of Mordovia, Saransk
Published: February 2023

Complete feeding of highly productive cows should be carried out with the use of biologically active feed additives, which is the main criterion for obtaining maximum milk productivity. Therefore, it is necessary to introduce optimal dosages of multicomponent feed additives into production, which contribute to increasing productivity and reducing the cost of production. The purpose of the work was to study the metabolism, productivity and technological properties of milk in cows when using the feed additive BioPrimum dry. The research was carried out under the production conditions of OOO “Agrosoyuz” in the Ruzaevsky municipal area in the Republic of Mordovia. The paper scientifically substantiates the possibility of using a new feed additive BioPrimum dry in the rations of cows of Red-and-White. Its optimal dosage has been established and the eff ect on the digestibility of nutrients and the use of mineral elements of the ration, the biochemical status of blood, dairy productivity of cows has been studied. The economic effi ciency of the use of the feed additive BioPrimum dry in cow feeding has been determined. The optimal dosage of the feed additive BioPrimum dry in the amount of 75 mg/ kg of dry matter in cow feeding has been established. Based on the results of production testing, the economic effi ciency of using the tested additive was calculated. The best indicators turned out to be in the cows of the experimental group, when converting the milk obtained to the basic fat content 517,8 kg or 5,8 % higher more milk was received from them. Revenue from sales amounted to 198 124,5 rubles or 10 874,5 rubles higher than in the control group. At the same time, an additional profit was received in the amount of 9935,7 rubles per cow.
Review of the opportunities of 5D-smeta program
Authors:   ", Gorinsky M. E. ,   Galaktika IT",   Сompany
Published: February 2023

Any construction is impossible without the use of nonmetallic construction materials. At the same time the problems about the provision of construction with nonmetallic building materials arise at the transportation stage. Moreover, each type of transport has its specific problems. The essence of these problems is considered in the article. Dynamics of the market and logistics of nonmetallic construction materials is analysed. Measures, which are proposed by the experts for stabilization of a situation, with the transportation of nonmetallic materials are considered.
Innovative ways of transportation of construction materials
Authors:   Moscow State University of Civil Engineering, Polyakova I. S. , Zorin К. А. ,   Moscow State University of Civil Engineering
Published: February 2023

Any construction is impossible without the use of nonmetallic construction materials. At the same time the problems about the provision of construction with nonmetallic building materials arise at the transportation stage. Moreover, each type of transport has its specific problems. The essence of these problems is considered in the article. Dynamics of the market and logistics of nonmetallic construction materials is analysed. Measures, which are proposed by the experts for stabilization of a situation, with the transportation of nonmetallic materials are considered.
Laparoscopic right hemicolectomy with aortocaval lymphadenectomy, and pelvic peritoneum partial resection for ascending colon cancer
Authors: Kim Hannah , Seo An Na , Park Soo Yeun
Published: February 2023

The aim of this video is to present the procedural details of laparoscopic right hemicolectomy with aortocaval (infrarenal aortic bifurcation) lymphadenectomy, partial resection of the pelvic peritoneum (peritoneal carcinomatosis index, 3), and hyperthermic intraperitoneal chemotherapy in a patient who received neoadjuvant chemotherapy for stage IVc colorectal cancer. The total operation time was 290 minutes, and the patient was discharged on a postoperative day 13 without any complications. No postoperative complications occurred until postoperative day 60. The pathological stage of the tumor was determined to be T3N2bM1c. The pelvic peritoneal nodule was pathologically confirmed as a metastatic lesion. Among the 12 harvested aortocaval lymph nodes, 6 were metastatic lymph nodes. The minimally invasive approach was safe and feasible in this highly selected patient with colon cancer, aortocaval lymph nodes, and peritoneal metastases.
DIGITALIZATION OF THE ECONOMY: PROBLEMS AND PROSPECTS
Authors:   Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I.S. Turgenev», Grigoryan G.S.
Published: February 2023

Digitalization of the economy is the main task of the state in the period from 2017 to 2030 in order to maintain a high level of competitiveness of the domestic economic system. The article examines the essence of the digital economy, analyzes the problems and prospects for the development of the national economy.
THEORETICAL, METHODOLOGICAL AND OBJECTIVE SETTINGS OF THE SYSTEM OF ANALYSIS OF THE SUSTAINABLE DEVELOPMENT OF THE ORGANIZATION
Authors:   Russian State Economic University (RINH), Guzey V.A.
Published: February 2023

Foreign experience in the functioning of economic entities as the main dominant, provides for a focus on sustainable development, in terms of improving the resulting performance indicators, realizing human potential, reducing the negative impact on the environment, focusing on strengthening relationships with modern institutions, as well as increasing the information transparency of doing business. The article reveals the essence of the analysis of sustainable development of the organization, its target setting, tasks, principles, objects, subjects.
FINANCIAL GLOBALIZATION AS A THREAT TO NATIONAL ECONOMIC SECURITY
Authors:   Omsk State Transport University (OSTU), Balashova Yu.G. , Kuvaldina T.B. ,   Omsk State Transport University (OSTU)
Published: February 2023

The article discusses the impact of global globalization on the economic security of the modern state. As a result of the study, the authors concluded that in the process of universal globalization, national producers often become dependent on foreign consumers. As a result, there are a number of problems with the «isolation» of the national element in the gross domestic product of the country.
FEATURES OF FORMATION AND IMPLEMENTATION OF A COMPETITIVE STRATEGY OF A SMALL ENTERPRISE IN THE REGIONAL MARKET OF TELECOMMUNICATION SERVICES
Authors:   Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I.S. Turgenev», Barsukova O.V.
Published: February 2023

Within the framework of this article, the issues of developing a competitive strategy for an enterprise in the telecommunications industry are explored. The author examined the features of the activities of a small enterprise in the regional market, conducted a SWOT analysis, on the basis of which competitive advantages were identified and directions for the strategic development of the enterprise were proposed to increase competitiveness in the telecommunications services market.
PROSPECTS FOR THE INTRODUCTION OF THE DIGITAL RUBLE IN THE FINANCIAL AND ECONOMIC TURNOVER OF THE COUNTRY
Authors:   Omsk State University of Railway Transport, Barynkina N.P. , Suprunova E.A. ,   Omsk State University of Railway Transport, Rudy L.A. ,   Omsk State University of Railway Transport
Published: February 2023

In recent years, in the context of globalization and digitalization of the economy, various types of digital financial assets, such as cryptocurrency, token, ethereum and others, have become very popular. Central banks of different countries have asked the question of the need to issue a digital national currency using blockchain technology. The Central Bank of Russia is also planning to issue a digital ruble. The appearance of the digital ruble among economic entities raises many questions about their assessment, reflection on accounts, and application in practice. The article presents the rationale for the introduction of the digital ruble, the feasibility of step-by-step testing of practical use in order to identify weaknesses in the country's payment turnover. A study was carried out to identify the attitude of Russian citizens to the introduction of the digital ruble into the country's payment turnover, taking into account factors such as education level and age The practical application of the results of the research presented in the article is possible provided that an appropriate legislative framework is formed that could create a regulatory structure for various types of digital financial assets in a rapidly changing world. The results and conclusions presented in the article can be used by the scientific and business community for further discussions.
THE SYSTEM OF INDICATORS FOR EVALUATING INNOVATIONS IN THE CONTEXT OF DIGITAL TRANSFORMATION OF THE ECONOMY
Authors:   Rostov State University of Railway Engineering, Tishchenko I.A.
Published: February 2023

The digital transformation of the economy is the introduction of a complex of automated programs for accounting, analysis, control, planning, forecasting of economic indicators. This article presents the systems of indicators for evaluating innovations in the conditions of digital transformation of the economy.
ACCOUNTING AND ANALYTICAL COMPONENT IN THE ECONOMIC STRUCTURE OF THE INNOVATIVE PROCESS OF AN INDUSTRIAL ENTERPRISE IN CONDITIONS OF SUSTAINABLE DEVELOPMENT
Authors:   Moscow International University, Lozhkina S.L. , Chetvertakova E.V. ,   Bryansk State University named after Academician I.G. Petrovsky
Published: February 2023

The article analyzes the economic structure of the innovation process of Russian industrial enterprises. The decomposition method determines the indicators of market and technological novelty, as well as the scale of diffusion of innovative products. In the study, the innovative activity of an industrial enterprise is analyzed from the standpoint of the influence of the degree of manufacturability of production capacities on economic activity in general. In order to obtain more detailed characteristics, it was proposed to group the types of economic activity into aggregates that meet specific characteristics of the degree of manufacturability according to the international classification used by the OECD. Industrial enterprises were considered taking into account their differentiation by groups of activities: high-tech, medium-tech, medium-low-tech and low-tech. A practical example shows and defines the key stages of the innovation process. In order to determine the degree of efficiency of using the resources of an industrial enterprise involved in innovation, the role of the accounting and analytical component in the structure of the innovation process is determined. Analytical coefficients of resource support for innovative activities of industrial organizations of enterprises are proposed to be grouped into blocks that allow a detailed assessment of the degree of efficiency in the use of resources.
MICROFINANCE ORGANIZATIONS IN DEVELOPMENT SMALL AND MEDIUM-SIZED BUSINESSES
Authors:   Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I.S. Turgenev», Fedorova O.A. , Fokina O.G. ,   Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I.S. Turgenev»
Published: February 2023

Support for small and medium-sized businesses in the current economic situation is a prerequisite for economic recovery after the problems associated with the pandemic. One of the important institutions within the framework of such support are microfinance organizations, which are represented on the market today by most microcredit companies. The article presents the concept and specifics of the activities of microfinance organizations in the Russian market of credit services. The analysis of microfinance organizations in the context of active and passive operations of their activities is carried out, the volumes of their participation in the market of entrepreneurial financing in 2018-2020 are given.