bluuebunny/crossref_metadata_2025 huggingface dataset:
SELECTION OF ANTAGONISTIC RHIZOBACTERIA POTENTIAL FOR BIOLOGICAL CONTROL OF Fusarium oxysporum
Authors: Anggit Cahyani  , Hamidson Harman , Suwandi Suwandi , Umayah Abu
Published: February 2024

Fusarium oxysporum is a pathogen that causes wilt disease in many plants and can couse losses of up to fifty percent. Standard control is to use synthetic fungicides. However, continuous use of fungicides has a high environmental risk, so environmentally friendly and safe control efforts are needed. One way is by using rhizosphere bacteria or rhizobacteria. This research aims to obtain rhizobacteria isolates that can control the pathogen F. oxysporum, which causes fusarium wilt in vitro. This research was conducted from June to July 2023. The methods in this research included isolating rhizobacteria, observing the morphology of bacterial colonies, gram staining, gram reaction test, catalyst test, and in vitro antagonist test. Research data shows that of the thirty rhizobacteria isolates observed, all isolates had the potential to inhibit the growth of F. oxysporum. The KMTK2 showed the highest inhibitory ability isolate with an inhibitory ability of 73,99%, and the lowest inhibitory ability was shown by the TBA1 isolate with an inhibitory ability of 51,56%. Potential rhizobacteria isolates can suppress the growth of the pathogen F. oxysporum and can be used as a biological agent to reduce the use of pesticides in treating plant diseases.
Pengembangan Modul Praktikum Virtual Berbasis Multirepresentasi untuk Meningkatkan Minat Siswa
Authors: Hasanudin Nurlaila , Faradiba Faradiba , Masta Ngia , Sianturi Manogari , Handayani Ida Sri , Olla Yufran Meliando
Published: February 2024

Perkembangan teknologi yang kian masif berdampak pada perkembangan sumber daya manusia saat ini, salah satunya proses pembelajaran siswa di sekolah. Penerapan teknologi yang telah merambah ke dunia pendidikan mengahasilkan media pembelajaran modern yang edukatif. Media pembelajaran ini diharapkan mampu menjadi alat penunjang proses pembelajaran yang kreatif dan menarik. Penelitian ini dilatar belakangi oleh hasil observasi terkait permasalahan sekolah yaitu tidak tersedianya modul sebagai bahan ajar yang dapat digunakan pada saat proses pembelajaran. Permasalahan lain yang didapatkan adalah tidak berlangsungnya proses praktikum yang dikarenakan kekurangan alat yang tersedia pada sekolah. Akibatnya, siswa di sekolah tersebut tidak dapat melakukan proses praktikum sebagimana mestinya Penelitian ini bertujuan untuk mengembangkan modul praktikum virtual PhET berbasis multirepresentasi untuk meningkatkan minat siswa. Indikator minat siswa mencakup perasaan senang, perhatian, ketertarikan dan keterlibatan siswa. Penelitian ini merupakan penelitian R&D (Research and Development) dengan metode Analysis, Design, Development, Implementaton and Evaluation (ADDIE). Hasil dari penelitian ini menunjukan pengembangan modul terhadap minat siswa dengan perolehan rata-rata mencakup keseluruhan indikator adalah 82% dengan kategori “sangat positif”. Modul praktikum virtual PhET berbasis multirepresentasi terhadap minat yang dikembangkan dalam kategori sangat positif, sehingga efektif digunakan dalam proses pembelajaran. Pentingnya pengembangan media pembelajaran di sekolah dilakukan dalam rangka peningkatan kulaitas sumber daya manusia yang selanjutnya menjadi generasi yang mampu membangun bangsa menjadi bangsa yang maju.
Non-attendance of appointments at the orthodontic clinic
Authors: Au Carmen , Li Jingyi , Jin Liying , Wu Tianyou , Guan Guangzhao , Mei Li
Published: February 2024

Aims

To investigate the non-attendance of patients at orthodontic appointments and to determine related reasons.

Methods

Appointment data were collected from the Faculty of Dentistry, University of Otago between August and October in 2013 (paper-appointment system using post letters) and 2019 (digital-appointment system using automatically generated short message service (SMS) texts before the Covid-19 pandemic). The demographic and time characteristics of patients who attended and failed their appointments were collected for statistical analysis.

Results

The total number of appointments was 5810, including 2761 by 1901 patients in 2013 and 3049 by 2009 patients in 2019. The overall fail to attend (FTA) rates were 16.1% in 2013 and 12.9% in 2019. Morning appointments showed a higher failure rate (16.0% in 2013 and 14.2% in 2019) than the afternoon appointments (12.1% in 2013 and 11.1% in 2019) (p < 0.05). Bonding appointments had a significantly lower failure rate (6.2%) compared with other treatment procedures with an attendance rate of 93.8% (p < 0.05). People living between the 901 and 950 (higher socioeconomic status, SES) suburb index were 1.5 times less likely to fail compared with people living in other categories (p < 0.05).

Conclusion

The fail to attend (FTA) of orthodontic appointments was approximately 15% in the Otago University Orthodontic Clinic, New Zealand. Patients from lower SES, Māori and Pasifika peoples, and morning appointments had higher FTA rates. Bonding appointments had the lowest FTA rate. FTA significantly decreased after the introduction of a SMS text reminder system. An effort is still required to improve the orthodontic attendance rate, and future studies could consider investigating the digital reminder systems, such as smart phone apps, to enhance clinical attendance in the electronic age.
Impact of Angle malocclusions on oral health related quality of life in adolescents
Authors: Akturk Ezgi Sunal , Yavuz Fatma Nur , Unsal Humeyra , Seker Elif Dilara
Published: February 2024

Objectives

To investigate the impact of Angle Class I, Class II, and Class III malocclusions on oral health-related quality of life (OHRQOL) in children aged 11 to 14 years.

Methods

The Turkish version of the Child Perception Questionnaire 11-14 (CPQ11-14) was administered to 83 individuals with a Class I malocclusion, 111 individuals with a Class II Division 1 malocclusion, and 63 individuals with a Class III malocclusion. The CPQ11-14 was used to evaluate the OHRQOL of children aged between 11 and 14 years. The questionnaire consisted of 37 questions which evaluated oral symptoms, functional limitations, emotional well-being, and social well-being.

Results

No statistically significant difference was observed between the groups in relation to the individual’s CPQ11-14 total scores and subscale scores for oral symptoms, functional limitations, and emotional well-being (p > 0.05), except for the social wellbeing subscale. Patients with a Class III malocclusion had significantly higher social well-being scores compared to individuals with a Class I malocclusion.

Conclusions

A Class III malocclusion may negatively impact on the social well-being of adolescents. Early diagnosis of a Class III malocclusion and the application of early orthopaedic treatment may prevent the negative impact on a child’s social well-being.
Bibliometric Analysis of Artificial Intelligence in the Scope of E-Commerce: Trends and Progress over the Last Decade
Authors: FRIOUI Samira , GRAA Amel
Published: February 2024

Artificial intelligence (AI) techniques are commonly used in e-commerce, but there is little bibliometric analysis in this field. Using a bibliometric approach, it conducted a comprehensive study over the past decade to assess the research landscape, progress, and emerging trends in the field of artificial intelligence in e-commerce. Data was collected from related literature in the Scopus database from 2014 to the first half of 2023. VOSviewer and R studio were used to perform the bibliometric analysis of AI in e-commerce. The author status, nations, affiliations, annual publications, keywords, and journals were all evaluated in this way. The oldest relevant article was published in 1994, and article reviews were the most common form of document among the 669 manuscripts. Furthermore, the most popular research areas in this topic are business, management, and accounting. Additionally, the most productive journal is Proceedings of the International Conference on Electronic Business (ICEB). Moreover, the UK is the country that has published the most articles, and in terms of co-authorship, it has the strongest overall link. Finally, the keyword co-occurrence network indicates that the most important keywords are machine learning, e-commerce, recommender systems, fraud detection, decision-making systems, data mining, and online retailing.
Indigenous Preservation Practices and Shelf Life of Stored Yams in Benue State, Nigeria: Implication for Post-Harvest Management and Food Security
Authors: ORJIME Emmanuel Verem , G. AHULE Benjamin , A. AKPEHE Godwin , GBAKA Solomon , IJIRSHAR Victor Ushahemba , O. ZAKA Kafayat
Published: February 2024

Several empirical studies have been conducted on the relationship between indigenous practices and yam tuber preservation. However, there is a lack of empirical evidence regarding the extent of effectiveness of the existing indigenous preservation practices in reducing yam postharvest losses with regard to prolonging the shelf life, which underscores an existing gap in knowledge. The purpose of this study is to examine the extent of effectiveness of existing indigenous preservation practices in prolonging the shelf life of stored yam tubers in Benue State, Nigeria, using a cross-sectional survey design based on a proportional sampling technique involving 255 respondents. The result of the chi-square test shows the probability value of 0.000<0.05; hence, the study rejected the null hypothesis. A symmetric Phi value of 0.635 was obtained, showing a positive association between the variables. Thus, application of the existing indigenous yam preservation practices led to the overall improvement in the shelf life of stored yams by 34%. The study recommends that government and nongovernmental organizations should provide both financial and technical assistance to rural yam farming families, in the form of loan facilities. Yam farmers should also form cooperative societies in order to borrow more funds from financial institutions. This will boost the expansion of storehouses to accommodate the increasing quantity of yam tubers harvested, provide good ventilation in stores, and enhance free traffic during the removal of sprout development in storehouses to avert yam tuber postharvest losses and prolong the shelf life of the stored yam tubers in the study area.
The Non-Agricultural Labour Productivity Effects of Working Time: South Africa’s Case
Authors: CHIPETA Chama , HABANABAKIZE Thomas , ZERIHUN Mulatu Fekadu
Published: February 2024

The purpose of the current study is to assess the impact of working time on non-agricultural labour productivity in the South African economy. To achieve this objective, the study utilised the Autoregressive Distributed Lag Model (ARDL) and correlation analysis to analyse the effects of different working time arrangements on labour productivity. The results of the study indicated that weekly working hours have a significant influence on worker productivity. Working between 30 and 39 hours per week was found to greatly enhance productivity both in the short and long term. Additionally, working between 15 and 29 hours per week showed a slight positive effect on productivity. Conversely, working more than 39 hours per week (between 40 and 45 hours) only increased productivity in the short term, while working less than 29 hours and exceeding 45 hours per week had a negative impact on labour productivity. These findings suggest that an optimal working schedule to maximise labour productivity is between 30 and 40 hours per week, with overtime not exceeding 5 hours per week. Establishing a proper schedule of weekly working hours is crucial for maximising labour productivity and reducing work-related stress, which can impede productivity.
The Impact of Financial Diagnosis Determinants on Corporate Financial Performance
Authors: TARHLISSIA Lamine , BENACHOUR Amira
Published: February 2024

The aim of this research is to identify and study the indicators of financial performance of large Algerian companies using the financial diagnosis method and its axes. Variables representing each axis of financial diagnosis (solvency, profitability, and profitability) were found. This study is based on a sample of forty (40) companies operating in the Algerian market over a period of five years from 2017 to 2021. The obtained results show that company size, profitability rate and self-financing capacity are significant determinants of the financial performance of large Algerian companies.
Public awareness of DEXA-scan in detecting osteoporosis A Cross-Sectional Study
Authors: Al_Rawi Mustafa , Saati Abdulaziz , Alhaidari Mohammad , AlAli Sultan , Melha Mishal , Alqarni Faisal , Alfryyan Abdulrahman
Published: February 2024

Background: Bone density disorders are a common group of disorders among the Saudi population and are widely misunderstood. Therefore, there is an increasing demand to raise awareness towards bone health and the importance of screening. Hence, the purpose of the study is to analyze the general population's comprehension regarding bone health and bone density screening via Dual Energy X-Ray Absorptiometry (DEXA) scan.
Methods: The study design that was utilized in this study was cross-sectional using an electronic questionnaire to evaluate the knowledge and awareness among the Saudi residents regarding DEXA scan and osteoporosis.
Results: The median knowledge score was 8 out of 20 regarding the previous knowledge in connection to DEXA scan, resulting in only 39.7% out of the 491 participants previously knowing about the imaging modality. In regard to the effect of the socio-demographic status on the knowledge of DEXA scan. Age, income, education level and occupation were greatly associated with the knowledge of DEXA scan.
Conclusion: The study focuses on the increasing requirement to enhance the general population's knowledge and awareness of the importance of screening for osteoporosis via DEXA scan through education and research regarding the topic. Higher utilization of DEXA scans can be a result of having previous knowledge about osteoporosis and the complications behind it, which may eventually result in the earlier detection of the disease leading to fewer complications and lowering healthcare disbursements.
KONFLIK KONTEMPORER DI PERKOTAAN
Authors: Resty Dwiyanti Andi Amytia
Published: February 2024

Abstract:

Conflict between villages in South Sulawesi Province is a conflict phenomenon with unique nuances, because it involves people from the same ethnic and religious groups, and often even have relatively close kinship ties.The only difference that stands out is the administrative area and boundaries of a city.This study aims to find the roots of inter-village conflicts that have occurred so far and identify local wisdom in South Sulawesi Province which can be used as a medium for conflict resolution and efforts to build social harmony in society.The research method used is qualitative through in-depth interviews, observation and documentation.The results showed that most of the inter-village conflicts were triggered by trivial issues that were personal in nature and then turned into more communal ones by highlighting differentiating identities based on regional boundaries so that they turned into inter-village conflicts.The inter-village and inter-village conflict resolution model that has been developed uses a customary approach, in which the peace agreement process is followed by the determination of customary sanctions that will be applied to parties who violate the agreement.

 

Keywords: Social Harmony, Local Wisdom, Inter-City Conflict, Model, Conflict Resolution

 

Abstrak:

 

Konflik antar desa di Provinsi Sulawesi Selatan adalah sebuah fenomena konflik dengan nuansa yang unik, karena melibatkan masyarakat dari kelompok etnis dan agama yang sama, Bahkan tidak jarangmemiliki ikatan kekerabatan yang relatif dekat. Perbedaan yang menonjolhanya wilayah administrasi dan batas wilayah suatukota. Penelitianinibertujuanuntukmenemukanakarkonflikantardesa yang selamainiterjadi dan mengidentifikasikearifanlokal di Provinsi Sulawesi Selatan yang dapatdijadikansebagai media resolusikonfliksertaupayamembangunharmonisosialmasyarakat. Metodepenelitian yang digunakanadalahkualitatifmelaluiwawancaramendalam, observasi dan dokumentasi. Hasil penelitianmenunjukkanbahwakonflikantardesakebanyakandipicu oleh persoalansepele yang bersifat personal laluberubahmenjadilebihkomunaldenganmenonjolkanidentitaspembedaberdasarkanbatas wilayah sehinggaberubahmenjadikonflikantardesa. Model penyelesaiankonflikantardesa dan antar kampung yang telahdikembangkanadalahdenganmenggunakanpendekatanadat, di mana proses kesepakatandamaidiikutidenganpenetapansanksiadat yang akanditerapkankepadapihak-pihak yang melanggarkesepakatan.

 

Kata Kunci: Harmoni Sosial, KearifanLokal, KonflikAntar Kota, Model, ResolusiKonflik
ANALISIS CULTURAL UNTRANSTABILITY TERHADAP PEMAHAMAN HUBUNGAN BUDAYA DAN BAHASA DI TIKTOK @bangjoeofficial
Authors: Wisudawaty Hanna , Lesmana Putri Naila Yumna , Helmalia Derin
Published: February 2024

Pertukaran informasi yang cepat melalui berkembangnya internet membuka jendela baru untuk melihat fenomena-fenomena sosial yang kerap terjadi di lingkungan masyarakat. Salah satu fenomena tersebut adalah cultural untranstability atau ketidakterjemahan budaya yang dapat dilihat melalui konten video unggahan @bangjoeofficial pada media TikTok. Penelitian ini bertujuan untuk menganalisis peristiwa cultural untranstability dalam konten video TikTok yang dipublikasikan oleh akun @bangjoeofficial dan dampaknya terhadap pemahaman hubungan antara budaya dan bahasa. Konten video TikTok saat ini merupakan salah satu bentuk media sosial yang popular yang sering digunakan untuk menyampaikan pesan budaya dan bahasa. Fenomena cultural untranstability merujuk pada ketidakstabilan atau konflik dalam budaya yang muncul melalui bahasa, sikap, atau interaksi sosial. Penelitian ini menggunakan metode analisis konten untuk menyelidiki konten video @bangjoeofficial yang mencakup berbagai bahasa, budaya, dan pesan budaya dalam berbagai konteks. Penelitian ini menyimpulkan bahwa konten video TikTok dapat memengaruhi pemahaman hubungan antara budaya dan bahasa dalam masyarakat. Namun, penelitian lebih lanjut diperlukan untuk memahami secara lebih mendalam dampak konten media sosial terhadap budaya dan bahasa serta bagaimana penggunaan bahasa dan simbol budaya dalam media sosial dapat memengaruhi pandangan masyarakat terhadap identitas budaya. Kesadaran budaya dan pendidikan tentang keragaman budaya juga penting dalam mengatasi tantangan yang mungkin muncul akibat perbedaan budaya dalam media sosial. Kata Kunci: bahasa, cultural untranstability, media sosial
KECEMASAN DALAM BERBICARA DI DEPAN UMUM PADA KALANGAN MAHASISWA BERUSIA 17-22 TAHUN
Authors: Rengganawati Hana
Published: February 2024

Kecemasan berbicara di depan umum merupakan fenomena umum yang dialami oleh banyak mahasiswa berusia 17-22 tahun. Menyadari pentingnya masalah ini dalam kehidupan akademis dan remaja. penelitian ini bertujuan untuk menggali tantangan unik yang dihadapi oleh individu dalam kelompok usia ini saat berbicara di depan umum. Dengan menerapkan pendekatan metode campuran dan melibatkan 200 responden, penelitian ini menggunakan perhitungan statistik untuk data kuantitatif yang diperoleh dari pengisian survei tujuh pertanyaan. Hasilnya menunjukkan bahwa sebagian besar mahasiswa mengalami kecemasan atau ketidaknyamanan saat menghadapi situasi seperti berbicara kepada orang yang memiliki posisi lebih tinggi, memberikan pidato, dan mengikuti wawancara. Manifestasi dari kecemasan ini melibatkan gejala seperti detak jantung yang cepat dan gemetar yang dikaitkan dengan perasaan ketidakamanan dan kebingungan. Di samping data berbasis angka, analisis mendalam dari informasi berkualitas yang diperoleh melalui tanggapan terbuka dapat memberikan pemahaman yang lebih komprehensif mengenai dimensi emosional dan kognitif dari kecemasan. Secara signifikan, penelitian ini menyediakan tips praktis dan strategi mengatasi, mencakup teknik persiapan sebelum berbicara dan mekanisme penanganan waktu nyata dengan tujuan mengatasi sisi holistik dari manajemen kecemasan berbicara di depan umum di kalangan mahasiswa pada kelompok usia ini. Kata Kunci: berbicara di depan umum, kecemasan, percaya diri
ANALISIS PERFORMANSI ALGORITMA SVM, CNN, DAN LSTM UNTUK PENGENALAN KEGIATAN MANUSIA DENGAN URAD FMCW RADAR
Authors: Ramadhan Azhar Yunda , De Fitrah Figo Azzam , Nurhidayat Muhammad Adi , Suratman Fiky Yosep , Istiqomah Istiqomah
Published: February 2024

In this study, we compare Support Vector Machine (SVM), Convolutional Neural Network (CNN), and Long ShortTerm Memory (LSTM) algorithms as commonly used machine learning algorithms based on FMCW Radar data for Human Activity Recognition (HAR). The comparison is conducted by evaluating the models on test data and considering the fitting time and the number of parameters required by each model to achieve the desired results, to find the most efficient model that provides the best results. We discovered that the LSTM 01 model with one layer of 16 unit-LSTM produces the best result based on the scoring of several tested models. The model demonstrated an ability to achieve accuracy up to 86% on the test data with a relatively small number of parameters, i.e., 294,725. Key Words: Radar, computation, FMCW, SVM, CNN, LSTM.
HUMAN ACTIVITY RECOGNITION IMPROVEMENT ON SMARTPHONE ACCELEROMETERS USING CIMA
Authors: Putrada Aji Gautama , Abdurohman Maman , Perdana Doan , Nuha Hilal Hudan
Published: February 2024

Human activity recognition (HAR) is a research field that focuses on detecting user activities and has wide applications. However, the problems that need to be solved are real-time constraints and imbalanced datasets due to different activity frequencies. Our research aims to apply classification integrated moving averages (CIMA) to HAR by evaluating its performance regarding real-time constraints and imbalanced datasets. We achieved the smartphone accelerometer dataset from Kaggle, which consists of several activities: walking, jogging, climbing, and descending stairs. We develop a general CIMA windowing algorithm with hyperparameters J and W. We benchmark CIMA with two state-of-the-art HAR methods: distributed online activity recognition system (DOLARS) and convolutional neural network (CNN). We conducted some imbalance and model size analysis. The test results show that, with J = 10 and W = 240, CIMA performs better than DOLARS and CIMA with recall, precision, and f1-score of 0.996, 0.993, and 0.994. We also prove that CIMA, assisted by quantization, has the smallest model size compared to the CNN and DOLARS model sizes. Finally, we demonstrate that CIMA performs well for imbalanced datasets, where CIMA’s recall on upstairs and downstairs activities is better than DOLARS and CNN, with values of 1.00 and 0.98, respectively. Key Words: classification integrated moving average, human activity recognition, smartphone, accelerometer, imbalanced dataset
Spatial Concepts within Syntactic Structures: The Topology-Imagery Hypothesis
Authors: Jia Junwen
Published: February 2024

The aim of this study is the creation and implementation of a groundbreaking syntactic structure typology, anchored in fundamental cognitive processes. This involves an in-depth classification and analysis of a variety of sentence types, integrating imagistic and spatial categories. This methodology promotes an in-depth comparative analysis, facilitating the discovery of distinctive syntactic features among the languages examined. The research is dedicated to a thorough exploration of sentence structure's topological aspects, scrutinizing the configuration and interplay of linguistic elements. It places particular emphasis on sentences within three diverse linguistic frameworks: Russian, Chinese, and English, thus enabling a comprehensive analysis and the identification of both cross-linguistic similarities and distinctions. This research adopts a multifaceted approach, combining theoretical analysis with comparative study. Such integration of methodologies allows for a nuanced comparison of sentence structures and their semantic roles in Russian, Chinese, and English, highlighting linguistic and cultural differences between these languages. The novelty of this study lies in the cognitive approach to sentence structure analysis and the development of a classification based on three cognitive models: (i) a single main container, (ii) dual main containers without a defined trajectory, and (iii) multiple main containers with distinct trajectories. A key principle of this classification is the integration of topological and imagery elements, underscoring the diversity of syntactic structures against a backdrop of a unified cognitive base, shaped by cultural and linguistic specifics. The findings reveal that sentences in Russian, English, and Chinese exhibit both shared and unique syntactic characteristics, reflecting cultural-cognitive differences, including the Chinese cultural concept of harmonizing opposites, the Russian cultural notion of segmenting the whole into parts, and the English cultural stance situated between these extremes.
Сause and Random Causation (on French Data)
Authors: Kordi E. E.
Published: February 2024

This article addresses the semantic similarities and differences between causative constructions (CiveC) and causal constructions (CsalC) in French, with its findings probably relevant for typology studies as well. A contrastive syntactic and semantic analysis of the two construction types shows that while syntactically different, they are similar semantically in that both express cause vs. consequence relations. This similarity is not, however, complete. French has three types of CiveCs: factitive constructions with the auxiliary faire, permissives with the auxiliary laisser, and constructions with notional causative verbs. Causal constructions exist in two types – multiclause constructions, and nominal constructions. Revealing the ability of CiveCs and CsalCs to undergo mutual synonymic transformations, the article concludes that the similarities/differences of their grammatical meanings depend on the randomness/non-randomness of the causation (cause). Random causation takes place in agency situations with active agents. Non-random causation emerges where one event generates/impacts the other one. The conclusions are the following: 1) the factitive construction faire + Inf. can express two grammatical meanings: a) cause, b) random causation/active purposive action; 2) permissive constructions normally express random causation, except for constructions with inanimate subjects; 3) notional causative verbs can express both meanings above; 4) causal, both nominal and multiclause, constructions never express random causation, invariably signaling cause.
Reversible Hyperpigmentation due to Vitamin B12 Deficiency - Mimicking Addison’s Pigmentation
Authors: Vijay V. , Ahmed Mustaq , Singh Yogindher
Published: February 2024

Vitamin B12 deficiency, which is usually seen in vegetarians, is characterised by cutaneous, gastrointestinal, neurological and haematological manifestations. Cutaneous manifestations include hyperpigmentation, glossitis and hair changes. Hyperpigmentation seen in Vitamin B12 deficiency mimics Addison’s disease. Here, we present a case of a 65-year-old male with vitamin B12 associated hyperpigmentation, which improved with B12 supplementation.
Jacques Handschin and the International Musicological Society. A Few Thoughts on the Congresses of the 1920s and 1940s
Authors: Князева Ж.В.
Published: February 2024

Статья продолжает серию публикаций, знакомящих с малоизвестными материалами из истории Международного музыковедческого общества (IMS) предвоенного и раннего послевоенного периодов. Речь идет о нескольких эпизодах борьбы вокруг поста и фигуры президента IMS, о полемике между членом директории IMS Жаком Гандшиным и президентом Общества Эдвардом Дентом. Развернувшиеся события отразили целый ряд научных тенденций в международном академическом музыкознании 1920-х — 1940-х годов. Исследование выстроено вокруг четырех конгрессов IMS: в Вене (1927), Кембридже (1933), Барселоне (1936) и Базеле (1949). В основу работы положены материалы прессы, а также документы из переписки Гандшина с его каталонским коллегой и другом, вице-президентом IMS Ижини Англесом.

This article continues the series of publications introducing little-known materials from the history of the International Musicological Society (IMS) in the pre-war and early post-war periods.  It deals with some episodes of the struggle over the post and figure of the IMS president, and the polemic between Jacques Handschin, a member of the IMS directorate, and Edward Dent, the Society’s president. The events reflected a range of scholarly trends in international academic musicology from the 1920s to the 1940s. The study is structured around four IMS congresses — in Vienna (1927), Cambridge (1933), Barcelona (1936), Basel (1949) — and based on press materials as well as documents from the correspondence between Jacques Handschin and his Catalan colleague and friend, IMS vice-president Higini Anglès.
Decoupling strategy-enabled radical generality via an asymmetric SH2 path
Authors: Fan Li-Wen , Tang Jun-Bin , Wang Li-Lei , Liu Ji-Ren , Li Zhong-Liang , Zhang Yu-Shuai , Yuan Dai-Lei , Qin Li , Luan Cheng , Gu Qiang-Shuai , Hong Xin , Dong Zhe , Liu Xin-Yuan
Published: February 2024

Reaction generality is essential for evaluating the value and impact of a synthetic method. However, asymmetric catalysis, particularly that involving highly reactive species such as radicals, typically prioritizes enantioselectivity at the expense of generality. Selectivity and reactivity often conflict because the bond-forming step is usually also stereodetermining. If these two steps were separated, the reaction selectivity and generality issues could then be addressed independently. Herein we report a catalytic asymmetric radical coupling with great generality by merging the copper-catalyzed enantioselective S(IV) center formation and copper-mediated enantiospecific SH2 radical coupling. This decoupling strategy has enabled the successful coupling of over 30 different carbon-, nitrogen-, and oxygen-based radicals having a broad range of reactivity with N-acyl sulfenamides, leading to diverse S-chiral compounds with exceptional enantioselectivity. Thus, it offers a holistic approach to accessing a rich portfolio of S(IV) and S(VI) chiral centers, which is anticipated to have a transformative impact on the synthesis of S-chiral compounds and benefit medicinal chemistry and other related fields. Furthermore, this decoupling strategy via SH2 processes has promising potential to enable a comprehensive single-electron methodology for forging other chiral centers with heteroatoms such as phosphorous(III) and silicon(IV), and eventually also carbon atoms.
Stereo-electronic effect of partial charge over oxygen atom in prolinol ether catalysts in Michael addition reactions of Propanal to β-Nitrostyrenes
Authors: Sahoo Jigyansa , Sahoo Gokarneswar
Published: February 2024

In this article, the utility of the synthesized prolinol derived organocatalysts in the Michael addition reaction of propanal with differently substituted β-nitrostyrenes has been discussed. The effect of the catalyst substitution on the reactivity of the reactions is studied along with the varying reactivity while using different electrophiles (in this case nitrostyrene).
Developing Measurement-Informed Methane Emissions Inventory Estimates at Midstream Compressor Stations
Authors: Ravikumar Arvind , Li Zhongju (Hugh) , Yang Shuting (Lydia) , Smith Mackenzie
Published: February 2024

Natural gas transmissions and storage compressor stations account for the largest share of methane (CH4) emissions in New York State (NYS). Yet, NYS’s CH4 emissions inventory is based on measurements that are a decade old and unlikely to be representative of NYS operations. Here, we present results from a comprehensive, multi-scale aerial CH4 measurement campaign across all NYS transmission and storage compressor stations. We find a skewed emissions distribution, with 20% of stations accounting for 74% of total CH4 emissions. Emissions at engine-driven compressor stations are, on average, 3-4x higher than emissions at turbine-driven compressor stations, thus demonstrating the need for separate emissions factors for engine- and turbine-drive compressor stations. Overall, measurement-informed emissions inventory from midstream transmission and storage compressor stations in NYS are 72% and 69% lower than the current NYS inventory, respectively. We estimate updated emissions factors of 464 [95% CI: 162 – 920] metric ton (MT) CH4/station/yr and 139 [97, 191] MT CH4/station/yr for engine- and turbine-based transmission compressor stations, respectively. Similarly, we estimate an updated emissions factor of 413 [164, 733] MT CH4/station/yr for engine-based storage compressor stations. These updated emissions factors, along with improved activity data, enable effective reconciliation of NYS inventory with measured emissions.
Atomic View of Photosynthetic Metabolite Permeability Pathways and Confinement in Cyanobacterial Carboxysomes
Authors: Sarkar Daipayan , Maffeo Christopher , Sutter Markus , Aksimentiev Aleksei , Kerfeld Cheryl , Vermaas Josh
Published: February 2024

Carboxysomes are protein microcompartments found in cyanobac- teria, whose shell encapsulates rubisco at the heart of carbon fixa- tion in the Calvin-Benson-Bassham (CBB) cycle. Carboxysomes are thought to locally concentrate CO2 and exclude O2 from the shell interior to improve rubisco efficiency through selective metabolite permeability, creating a concentrated catalytic center. However, per- meability coefficients have not previously been determined for these gases, or for CBB cycle intermediates such as bicarbonate (HCO3 – ), 3-phosphoglyceric acid (3-PGA), or ribulose-1,5-bisphosphate (RuBP). Starting from a high resolution cryo-EM structure of a synthetic β-carboxysome shell, we perform unbiased all-atom molecular dynamics (MD) to track metabolite permeability across the shell. The synthetic carboxysome shell is found to have similar permeability coefficients for multiple metabolites, and is not selectively permeable to HCO3– relative to CO2. To resolve how these comparable permeabilities can be reconciled with the clear role of the carboxysome in the carbon-concentrating mechanism in cyanobacteria, complementary atomic-resolution Brownian Dynamics (ARBD) simulations estimate the mean first passage time for CO2 assimilation in a crowded model carboxysome. Despite a relatively high CO2 permeability of 10−2 cm/s across the carboxysome shell, the shell proteins reflect enough CO2 back towards rubisco that over 2600 CO2 molecules can be fixed by rubisco for every 1 CO2 molecule that escapes under typical conditions. The permeabilities determined from all-atom molecular simulation are key inputs into flux modeling, and the insight gained into carbon fixation can facilitate the engineering of carboxysomes and other bacterial microcompartments for multiple applications.
Efforts towards Michael addition of isobutyraldehyde to β-methyl-β-nitrostyrenes
Authors: Sahoo Jigyansa , Sahoo Gokarneswar
Published: February 2024

This article describes the attempt towards racemic Michael addition reaction of isobutyraldehyde with branched nitrostyrenes. The reactions yield the Michael adduct in part but mostly undergo an undesired reverse reaction due to nucleophilic attack of pyrrolidine on the nitrostyrene. A detailed discussion reasoning for the poor forward reaction and the kinetics of the reverse hydrolysis of the nitrostyrene has been documented.
Selection of DNA-encoded Chemical Libraries for Compounds that can Induce Protein Ubiquitination
Authors: Huang Cen , Liu Xingyuan , Wu Xinyuan , Meng Ling , Lu Xiaojie , Li Xiaoyu
Published: February 2024

We report a selection method of DNA-encoded libraries (DELs) that can identify the compounds able to induce ubiquitination of the protein of intertest (POI). Since the selection readout of the method is based on POI ubiquitination, rather than POI binding or ternary complex formation, the identified compounds are more functionally relevant and more predicative of active protein degraders. In this study, by selecting a DEL of 950 different combinations of POI ligands, linkers, and E3 ligase ligands against the BD1 domain of bromodomain-containing protein 4 (BRD4-BD1) in the presence and absence of ATP, we have identified a potent BRD4-BD1 degrader (DC50: ~9.7 nM) and also a short-isoform-selective BRD4 degrader (DC50: 0.26 μM). Furthermore, we show that the selection based on POI binding or ternary complex formation identified compounds that may have induced stable complexes but are inactive degraders. This approach may be an efficient and broadly applicable method for discovering functional protein degraders, as well as E3 ligase ligands, by harnessing the vast chemical diversity of DELs.
Kinetic barrier networks reveal rate limitations in ion selective membranes
Authors: Kingsbury Ryan , Baird Michael , Zhang Junwei , Patel Hetal , Baran Miranda , Helms Brett , Hoek Eric
Published: February 2024

While polymer membranes are used to remove salts from environmental and industrial electrolytes, it remains a significant challenge to engineer them to isolate a single dissolved species from complex mixtures, which is important for lithium mining, battery and magnet recycling, and microelectronics. Underpinning this challenge has been a lack of understanding of rate-limiting mechanisms in selective ion transport. Here, we show that hydrated ions exhibit higher free energies of activation when crossing solution–membrane interfaces (i.e., partitioning) than when diffusing through polymers, which challenges historical assumptions embedded in widely used models of membrane performance. We further articulate a framework benchmarked with quantitative capabilities for predicting how functionality within polymer membranes or at their surfaces affects the selectivity towards individual dissolved species.
Factores asociados a un tamizaje auditivo anormal en recién nacidos críticamente enfermos: un estudio descriptivo
Authors: Valverde Zavaleta Adriana , Peña-Alejandro María Del Socorro
Published: February 2024

RESUMEN

ANTECEDENTES. En México, la hipoacusia neonatal se presenta en el 6-10% de los recién nacidos en la UCIN. Es importante conocer los factores asociados a hipoacusia neonatal para identificarlos y dar un seguimiento más estrecho a los pacientes de alto riesgo.

OBJETIVO. Conocer los factores asociados a un tamiz auditivo anormal en recién nacidos críticamente enfermos ingresados en la UCIN.

MATERIAL Y MÉTODOS. Realizamos un estudio retrospectivo, descriptivo, transversal, unicéntrico. Incluimos  recién nacidos entre 24-42 SDG ingresados en la UCIN a quienes se les realizó un tamiz auditivo en las primeras 72 horas del ingreso. Usamos pruebas de U de Mann Whitney y chi cuadrada de Pearson para comparar las características de los grupos con tamiz auditivo anormal y normal. Usamos tablas 2x2, con odds ratio e intervalos de confianza del 95% para obtener los factores asociados a tamiz auditivo anormal.  Todas las pruebas fueron bivariadas. Se consideró un valor de p=0.05 significativo.

RESULTADOS. Incluimos 110 recién nacidos críticamente enfermos. La prevalencia de un tamiz auditivo anormal fue del 20.9%. Los factores que se asociaron a un tamiz neonatal anormal fueron: crisis convulsivas neonatales (OR=13, IC95%, 4.5-37.6), peso ≥2.2kg (OR= 0.77, IC95%, 0.68-0.87) y displasia broncopulmonar (OR=12.9, IC95%, 1.3-130.6).

CONCLUSIONES. Es importante conocer los factores asociados a hipoacusia neonatal para poder identificar a los pacientes que se beneficiarían de un seguimiento más estrecho aunque el tamiz auditivo inicial sea catalogado como “normal”.
Evaluación de la coadministración en el tratamiento de pacientes con SARS-CoV-2 y los medicamentos para tratar comorbilidades mediante redes neuronales artificiales
Authors: Aguilar Lasserre Alberto Alfonso , Meza Palacios Ramiro , Pérez Tezoco Jaime Yair , Torres Martínez Diana Fernanda , Escobar Merino Norely Raquel , Vásquez González Hugo , Vázquez Rodríguez Carlos Francisco
Published: February 2024

El objetivo de este trabajo es desarrollar una herramienta de soporte a la decisión clínica para evaluar el resultado de la interacción de los medicamentos utilizados para tratar el SARS- CoV-2 y la coadministración de medicamentos para tratar comorbilidades.

Se utilizan redes neuronales (RNs) para realizar la predicción de los resultados de la interacción de medicamentos. El modelo ha sido desarrollado utilizando una red neuronal artificial del tipo PNN (Red neuronal probabilística) /GRNN (Red neuronal de regresión general). Una vez que la red neuronal artificial fue entrenada, probada y validada, se obtuvo un coeficiente de determinación del 82.79%, con lo que se pueden tener predicciones buenas y rápidas para conocer el resultado de la interacción de medicamentos específicos para el SARS- CoV-2 con otros fármacos para tratar diferentes enfermedades.

Para el entrenamiento de la RN se utilizó una base de datos, considerando nueve fármacos para tratar el SARS- CoV-2 y 10 categorías de medicamentos para tratar otros tipos de padecimientos. En la literatura existen estudios que demuestran la importancia de la correcta coadministración de medicamentos. Sin embargo, no existen, actualmente, herramientas que integren el uso de redes neuronales y el nuevo conocimiento obtenido de las respuestas ante las interacciones entre fármacos, que pueden ser utilizados de primera mano por los especialistas en el tratamiento disminuyendo con el riego de dicha interacción. Por ello, este trabajo pretende abordar esta brecha en el conocimiento. Este sistema puede ser utilizado como una herramienta de apoyo a la decisión, para evaluar y seleccionar entre el mejor tratamiento a utilizar en un paciente con SARS- CoV-2, y evitar complicaciones por la interacción negativa que puede provocar con otros medicamentos.
Validez y Fiabilidad del Inventario de Burnout de Maslach en México
Authors: Diaz Eduardo R. , León Bon Tiare Stephanie
Published: February 2024

Objetivo: Esta investigación busca aportar evidencia de validez de constructo y consistencia interna del Inventario de Burnout de Maslach en su versión en español para profesionales de la educación. Metodología: Se aplicó una encuesta con 110 docentes de una institución educativa en Baja California, México, y los datos se interpretaron mediante análisis factorial exploratorio y confirmatorio. Resultados: Los hallazgos señalan que se sostiene la estructura de tres factores del instrumento. Limitaciones:  El instrumento fue validado en una institución educativa con características específicas, por lo que los resultados podrían cambiar en caso de utilizarse en contextos diferentes. Valor: Este estudio es novedoso por tratarse del análisis de un instrumento para medir el burnout en profesionales de la educación, un tema poco explorado en México. Conclusión: El cuestionario sostuvo su estructura y esta investigación se suma a trabajos anteriores donde el cuestionario fue validado en diferentes contextos.
Presentación Editorial
Authors: Pérez Martínez Arizbeth Amitzin , Guadarrama Muñoz Alma Cossette , Vázquez Espinoza de los Monteros Roberto Antonio
Published: February 2024

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Persistent Narratives: Intellectual Disability in Canadian Children’s Literature
Authors: Collins Kimberlee , McGonegal Julie
Published: February 2024

Canadian children’s literature rarely depicts characters labelled with intellectual disabilities, yet when it does it often remains mired in stereotypes that recycle prevalent myths and misconceptions. Even as more recent literature attempts to push back against such stereotypes, it nevertheless predominantly remains caught in these dangerous representational repertoires. This article offers a brief history of Canadian literary depictions of intellectual disability and a critique of the Canadian publishing spheres. Through a critical analysis of Lorna Schultz Nicholson’s book Fragile Bones, we discuss the limits of representation of intellectual disability in children’s fiction. We also offer a critique of the ableist publishing climate in Canada and suggest that structural barriers prevent disabled writers from entering the literary marketplace on an equal playing field. These barriers to publishing lead to the vast underrepresentation of disabled authors and the misrepresentation of disability in general and intellectual disability in particular in Canadian children’s literature.
Portraits of Resistance: Exploring Intra-personal, Social, and Institutional Resistances through the Use of Arts-Based Research among Racialized Parents of Autistic Children and Youth
Authors: Moola Fiona J. , Moothathamby Nivatha , Posa Stephanie , Naganathan Methuna
Published: February 2024

The lives of children who live at the intersectional nexus between childhood autism and race may be considered as “shadow stories” that have remained silenced in autism literature. We explored the experiences of racialized parents who provide care to autistic children. We drew on a theoretical framework known as DisCrit and decolonizing arts-based methodologies. Racialized parents of autistic children demonstrated resistance along various themes, including fighting the system, protecting my child, and creating cultural communities. We join black girlhood studies, critical race theory, and disabled children’s childhood studies by continuing the journey of decentering Whiteness in childhood disability research. We demonstrate how disabled racialized communities engage in activism and social justice while forming powerful counter-discourses.
Towards a Feminist Research Ethics of Care: Reflections, Lessons, and Methodological Considerations for Doing Research During a Pandemic
Authors: Miele Rachelle , Root Jennifer , Godderis Rebecca , Meerai Sonia
Published: February 2024

Conducting feminist research during the global COVID-19 pandemic has evoked a renewed interest in the concept of care within our research team. The purpose of this paper is to provide concrete examples of how feminist ethics of care changed the initial and ongoing design of a community-engaged research project in Ontario, Canada. Drawing from examples and lessons learned, we focus on various adjustments to our methodological decision-making that intentionally honoured and prioritized our responsibilities to community partners, research participants, broader communities impacted by research, and the research team. By illustrating the methodological and ethical implications of these decisions, we argue that attending to these responsibilities prioritized both feminist research ethics and feminist ethics of care. As a result, we propose moving towards a conceptualization of a feminist research ethics of care, and discuss the value of this concept for researchers studying social justice.
PENGARUH KUALITAS LAYANAN, KEPERCAYAAN DAN PERSEPSI HARGA TERHADAP LOYALITAS PELANGGAN
Authors: Tsania Luthfiyah Hilmii , Haris Murwanto
Published: February 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variabel kualitas pelayanan, kepercayaan, dan persepsi harga terhadap loyalitas pelanggan di Bengkel Yoko Motor Semarang.

Penelitian ini menggunakan metode purposive sampling. Pengujian data yang digunakan meliputi uji validitas dengan membandingkan r hitung dan r tabel, uji reliabilitas dengan Cronbach Alpha. Uji asumsi klasik dengan uji normalitas, uji multikoloneritas, uji heteroskeditas. Uji analisis regresi linear berganda digunakan untuk menguji dan membuktikan hipotesis penelitian. Dan uji hipotesis dengan uji t, koefisien determinasi (R2 ).

Hasil penelitian ini menunjukan bahwa variabel kualitas pelayanan, kepercayaan dan persepsi harga berpengaruh positif dan signifikan terhadap loyalitas pelanggan pada Bengkel Yoko Motor Semarang. Hasil penelitian ini memberikan implikasi bahwa faktor kualitas pelayanan, kepercayaan dan persepsi harga adalah hal yang perlu diperhatikan untuk meningkatkan loyalitas pelanggan agar lebih baik lagi demi tercapai tujuannya.