bluuebunny/crossref_metadata_2025 huggingface dataset:
HIFα as a target for different oncoproteins during carcinogenesis
Authors: Kobliakov V. A.
Published: January 2019

The basic characteristics of tumours are ability for invasiveness and metastasis. These properties are realized due to destruction of intercellular matrix caused with acidification of intercellular area stimulated with transition from tissue respiration to glycolysis. The transition  to glycolysis in tumor cells is observed not only during hypoxic state how is realized in normal cells but also during oxygenation (Warburg  effect). It is accepted that by any carcinogenic action the activation of oncogenes or inactivation of genes – supressors occurs. As a result  it is permanent expression of oncoproteins and stimulation of tumour development. Different oncoproteins operate in different regulation systems at that they cause the same effect – tumour development.

It is assumed that oncoproteins are not the ultimate factor in tumour development but there are existed some common element which is activated by different oncoproteins. In this review it is assumed that common element is HIFα (hypoxia-inducible factor α) transcription factor and it is discussed the mechanisms its activation by oncoproteins takes place in different signal systems.
Small GTPase Rab3B: biological properties and possible role in carcinogenesis
Authors: Budko A. A. , Khesina P. A. , Diakov L. M. , Lazarevich N. L.
Published: January 2019

Proteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins, devided to 5 major families (Arf, Ran, Rho, Ras and Rab), and plays an important role in carcinogenesis. Compared to the other families, the Rab family was investigated by relatively small number studies, which does not equally reflect their role in malignant transformation processes. In our review  we have focused on both the subfamily Rab3 and its poorly investigated member Rab3B. Recent findings allow to consider Rab3B not only  as a promising diagnostic or prognostic marker for several types of neoplasms, but also is a potential target for antitumor therapy. Our analysis of publicly available transcriptional databases revealed that kidney, lung and liver cancer patients with low Rab3B gene expression demonstrate a better overall five-year survival.
The role of integrins αv in the pathogenesis of oral squamous cell carcinoma
Authors: Tuguzbaeva G. M. , Pavlov V. N.
Published: January 2019

The initiation of carcinoma progression is attributed to significant disorders in the synthesis of macromolecules that affect physiological processes in the epithelial cells of oral mucosa. It is known that the integrin family receptors are crucial for regenerative and reparative functions of the normal epithelium. In addition to their well-established physiological role, some types of integrins are the major determinants of malignant transformations. In particular, the results of recent studies in molecular oncology reveal the importance of αv integrins in the pathogenesis of carcinomas, including oral squamous cell carcinoma. This review aims to analyse the significance of αv integrins in the key processes of malignant growth and metastasis of oral squamous cell carcinoma. The prospects of using αv integrins as prognostic molecular markers and targets for developing novel diagnostic and therapeutic methods in the management of oral cancer are discussed.
Wnt-signaling pathway in pathogenesis of glioblastoma multiforme
Authors: Vasilets Yu. D. , Arnotskaya N. E. , Kudryavtsev I. A. , Shevchenko V. E.
Published: January 2019

The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in stem-like cells, called cancer stem cells, in different kinds of tumor, including multiform glioblastoma. The Wnt-signaling promotes stemness, invasion, metastasis, therapeutic and immune resistance of cancer stem cells in multiform glioblastoma. To summarize, targeting the Wnt-signaling pathway as an oncogenic driver is the future hope for effective therapy of glioblastoma for which current standard therapy is not effective.

In this review, we focused on functions of the Wnt-signaling in cancer stem cells and involvement of the Wnt-signaling pathway in gliomagenesis.
VOLUNTEERING AS A FACTOR IN THE FORMATION OF MORAL STANDARDS AMONG YOUNG PEOPLE
Authors: Popova N. V. , Popova E. V.
Published: January 2019

Introduction.Volunteering is a socially significant activity, which contributes to solving separate acute social issues and showing the best qualities of an individual – compassion, ability to sympathise and readiness to provide assistance to people in need. Through volunteering, a person achieves self-esteem and a feeling of his or her relevance and usefulness. Under the present circumstances, aspects of the study of volunteering and youth attitudes to this concept are especially relevant. Over the last decades, social transformations have occurred, leading to a reassessment of the value system, and, consequently, society has lost its moral compass. Participation in volunteering can become one of the effective factors in the formation of ethical standards and humanistic value orientations among young people.

Theaimof the research was to investigate the educational potential of volunteering through studying the attitudes of young people.

Methodology and research methods.The research was based on axiological and sociological approaches. In the course of the research, the following methods were used: review and synthesis of historical-philosophical and sociological literature, sociological group face-to-face surveys, and comparative analysis of statistical data.

 Results and scientific novelty.The authors justified the necessity for moral education of working youth through the involvement of young people in realizing charitable projects and organising philanthropic events. The authors highlighted the aspects of conducting charitable activities in one of the socially-oriented enterprises of the Urals – Sinarsky Pipe Plant. A questionnaire based survey conducted among young workers of that metal manufacturer revealed the fact of mass participation in various charitable activities (out of the sample seize of 180 young workers, 89% of respondents admitted their involvement in philanthropic activities). The respondents expressed interest in charitable projects and readiness to spend own time, energy and money for rendering disinterested targeted assistance to children with special needs and children with disabilities (56.3%), to elderly people living in difficult life situations (52.5%), to stray animals (50.0%), to children suffering from cancer (49.3%). It was concluded that charity work forms ethical standards at young people, and develops altruistic qualities such as disinterestedness and responsiveness, as well as civil consciousness.

Practical significance.The research outcomes can be used when preparing, organising and holding charitable work with the aim of bringing up morally and ethically educated young workers, as well as students of educational institutions of different levels.
El influencer de moda como sujeto de relaciones públicas: recursos y herramientas
Authors: Villena Alarcón Eduardo
Published: January 2019

Internet y las redes sociales han favorecido la aparición de un nuevo perfil profesional dentro del mundo de la moda: el influencer. Un gran número de empresas han incorporado ya a sus estrategias de comunicación las relaciones con estos nuevos líderes de opinión; los cuales se han revelado como auténticos prescriptores de las firmas de moda. Sin embargo, son exiguos los estudios que ponen de manifiesto la importancia de esta nueva figura y la necesidad de identificarlos correctamente. Por ello, la consiguiente investigación propone una revisión documental que permita dirimir el verdadero valor de las acciones con influencers como estrategia de relaciones públicas 4.0.; así como determinar cuáles son los recursos y las herramientas más importantes para lograr seleccionar quiénes más nos convengan. De los resultados arrojados por la investigación podemos dilucidar una necesidad por parte de las relaciones públicas de aportar un valor estratégico a esta actividad. Concluye un documento que aporta una hoja de ruta por recursos y herramientas que permite a los directores de comunicación identificar correctamente a estos nuevos colaboradores en función de sus necesidades y objetivos.
Comunicación política y emigración. Acciones de relaciones públicas del gobierno de Galicia en las colectividades gallegas de Iberoamérica
Authors: Fernández-Souto Ana Belén , Puentes-Rivera Iván , Vázquez Gestal Montse
Published: January 2019

La emigración gallega a América ha resultado tan importante a lo largo del siglo XX, que en muchos países de ese continente Galicia es denominada la madre patria y los españoles, por extensión, son conocidos como gallegos. Dada la importancia numérica y cualitativa, en cuanto a su peso en determinados sectores económicos, de emigrantes de esta comunidad autónoma en muchos países iberoamericanos, el presente artículo analiza la trascendencia que la Xunta de Galicia (el gobierno autonómico) concede a esos emigrantes y a sus descendientes, con nacionalidad española, debido fundamentalmente al papel que juegan en los procesos electorales en España, en general, y en Galicia, en particular, voto que en elecciones municipales es determinante a la hora de elegir alcaldes y alcaldesas en varios ayuntamientos.

Para ello se analizarán las acciones comunicativas que se desarrollan al amparo económico de la Xunta en los centros gallegos (agrupaciones de emigrantes de este origen en cada país) y, sobre todo, las visitas institucionales de los Presidentes de Galicia a Iberoamérica.
The National Research System and Scientific Policy of France in XXI century: key areas and development trends
Authors: Kravtsov A. A.
Published: January 2019

Purpose:the article is aimed at studying the present state and current trends in R&D activities of France in the context of French state scientific policy. For that purpose the French scientific policy’s main areas and instruments were analyzed, the principle shifts were highlighted. The transformation of the French scientific policy was examined and assessed.

Methods:in the article there were used such methods as description, comparison, system principle, analytical approach and tabular method.

Results:by research findings the course of the French scientific policy’s transformation under the EU influence was stipulated. The crucial, to the author’s mind, areas of the French scientific policy were defined. Some current development trends of the French R&D activities’ were stipulated.

Conclusions and Relevance:it was proved that under the EU influence France is gradually shifting away from its traditional tough regulation of the national innovation system toward stimulating private innovations and developing R&D infrastructure. Among crucial areas and instruments of the French scientific policy there were: direct financing; providing tax reliefs; regionalization and clusterization; support of SMEs; development of universities’ research potential; stimulating cooperation between research institutions, just as between research institutions and industrial firms. Among crucial trends of change there were: R&D expenditures increase among universities and industrial companies, including fundamental research R&D; state research institutes’ R&D expenditures downfall in 2010 and their further stagnation; attempts to copy some US innovation development experience. It was shown that the reforms implemented, though get some increase of R&D activity of commercial firms, are not effective enough, according to some experts, because of bureaucratization and sometimes come down to creation of new bureaucratic institutions or their merging.
Increasing the "Productivity" of the Academic Sector and Ensuring Cooperation with the Large Corporate Sector in Japan
Authors: Kostyukova K. S.
Published: January 2019

Purpose:the main purpose of this article is to review the Japanese policy to promote cooperation between the academic and large corporate sectors in the field of science and technology, and to analyze its role in the formation of the innovation system in Japan.

Methods:this article is based on the analysis of scientific and analytical materials on the problem of research. The factual basis is the framework documents of the Cabinet of Japan.

Results:the article provides a brief retrospective review on the support policy for universities and large corporate sector cooperation, identifies the key factors for the establishment of intersectoral cooperation; identifies the problem areas of the implemented policy that hinder the achievement of the set goals. The relative failure of the applied measures in the sphere of venture business support, commercialization of technologies and other instruments was noted. The hypothesis is put forward about the insufficiency of government efforts to monitor and analyze the activities already implemented, the lack of practice of taking into account failures in the formation of new programs and projects. Also revealed contradictions between the support programs implemented through various government agencies, which also leads to the inefficiency of scientific and technological projects and the establishment of dialogue with the corporate sector, including the need to resolve bureaucratic disagreements. It is also necessary to emphasize, that Japanese experience in implementing of science and technology and innovation policy is very important for Russian economic development. In particular, special attention is paid to study foreign experience in creating an effective mechanism of academic and private sectors interaction, where the key-supporting role is played by government in case of Japan. No doubt, it is not justified to try to copy any foreign institutional system, but the analysis of the negative and positive effects of foreign economic system cases is very valuable for self-institutional mechanisms development.

Conclusions and Relevance:the analysis leads to the conclusion that Japan has not yet completed the transformation to a modern model of the national innovation system, the current problem is the weakness of relations between the academic and corporate sectors. At the same time, there is an excessive, "paternalistic" role of the state in the organization of intersectoral interactions, in the absence of attention to the optimization of conditions and incentives for this kind of dialogue. The Japanese government actively supports and tries to develop the practice of "open innovation" business model, but due to the obsolescence of existing institutional structures, as well as their unpreparedness to the development and perception of radically new business models, has not yet been able to achieve concrete sustainable results.
COMUNICAÇÃO, RELIGIOSIDADE E CULTURA POPULAR: UMA COMPREENSÃO A PARTIR DAS RENOVAÇÕES EM JUAZEIRO DO NORTE-CE
Authors: Sousa Silva Francisco Mário de , Alencar Waléria Maria Menezes de Morais , Filho Ademar Maia , Ferreira Michel Monteiro , Do Nascimento Verônica Salgueiro
Published: January 2019

Esta pesquisa objetivou compreender aspectos da comunicação, religiosidade e cultura popular, a partir das Renovações ao Sagrado Coração de Jesus e Imaculado Coração de Maria, em Juazeiro do Norte, município localizado na Região do Cariri Cearense. Para esta compreensão, utilizou-se como principal instrumento metodológico, a pesquisa participante, concretizada entre julho de 2017 e julho de 2018. Os resultados foram avaliados sob a perspectiva qualitativa, a partir da triangulação de dados. Constatou-se que, a devoção, é uma expressão religiosa híbrida que, reflete aspectos culturais e religiosos locais, perpetuados por meio da comunicação da fé. Por fim, salienta-se a relevância de estudos que contemplem características religiosas e culturais, a partir do campo da comunicação, reforçando a compreensão da comunicação como, aspecto intrínseco as dinâmicas socioculturais.
O QUINHÃO DA BANDA MARCIAL NA FORMAÇÃO DOS ALUNOS DO CEPI-ISMAEL SILVA DE JESUS
Authors: Sousa Aurélio Nogueira de , Soares Maíry Aparecida Pereira
Published: January 2019

O presente artigo é uma reflexão sobre a relevância do ensino da Banda Marcial Cepi-Ismael Silva de Jesus para a formação dos alunos que a integram. O objeto, ora analisado, é componente curricular da Base Diversificada de Ensino e visa propiciar o desenvolvimento das diferentes linguagens, além de proporcionar a expressão e comunicação de ideias, a interpretação e a fruição de produções culturais. Trata-se de um estudo experimental aplicado no grupo de alunos que têm os primeiros contatos com a música por meio de métodos de ensino coletivo de instrumento musical “Tocar Junto” e “Da Capo”. A metodologia segue revisão de literatura, pesquisa de campo e análise de material didático. As primeiras conclusões sobre este estudo permitem inferir que o ensino da Banda corrobora para que os estudantes se tornem copartícipes da construção do seu próprio conhecimento, bem como do currículo escolar por meio de atividades que oportunizam uma visão crítica necessária ao desenvolvimento de sua vida social.
NONIMATA 2018
Authors: Neves Silva Rosemary Francisca
Published: January 2019

RELAÇÃO DE PARECERISTAS AD HOC FRAGMENTOS DE CULTURA
A Transition of Internationalisms: Britain, the United States, and the Formation of the United Nations Information Organization during World War II
Authors: Scott-Smith Giles
Published: January 2019

The United Nations Information Office (UNIO), dating from 1942, holds the distinction of being both the first international agency of the embryonic UN network and the first to hold the United Nations label. Run from 1942 to 1945 from two offices in New York and London, these two were merged at the end of World War II to form the UN Information Organisation, and subsequently transformed into the Department of Public Information run from UN headquarters in New York. This article adds to the history of the UN by exploring the origins and development of the UNIO during 1940–41, when it was a British-led propaganda operation to gather US support for the allied war effort. It also examines the UNIO from the viewpoint of the power transition from Britain to the United States that took place during the war, and how this reflected a transition of internationalisms: from the British view of world order through benevolent imperialism to the American view of a progressive campaign for global development and human rights.
Comparative analysis of the data on the structure of omental bursa
Authors: Kurtseva A. A. , Chernomortseva E. S. , Konyukhova M. G.
Published: January 2019

This essay is about the differences in the description of the upper story of the peritoneal cavity, the omental bursa and omental (epiploic) foramen, which connects the omental bursa (lesser sac) with the rest of the peritoneal cavity (greater sac). The difference in the description of the omental bursa causes misunderstanding during the study of the topic «The stories of the peritoneal cavity». The misunderstanding is especially well expressed when we teach the foreign students because there is a great difference in the description of the omental bursa in Russian and English literature. That is why we decided to analyze the data of the omental bursa in different literal sources. We analyzed 11 textbooks, 5 of the mare Russian and 6 of the mare English, most useful for the students during the preparing the material for Anatomy classes. The results are given in tables.
Anatomist, Whose Name is Forever Written into the Chronicle of Rostov Anatomical School
Authors: Chaplygina E. V. , Kaplunova O. A. , Kuchieva M. B. , Krymshamkhalova S. D.
Published: January 2019

The article is devoted to Alla Valentinovna Markevich, candidate of medical sciences, associate professor of the department of normal anatomy, Rostov state medical university. Her scientific and pedagogical activity, contribution to the development of the Rostov anatomical school are covered.
Comparative analysis of physical development indicators of young Sambo athletes and normative indicators for adolescents not involved in sports
Authors: Vybornov V. D. , Nikityuk D. B. , Badtieva V. A. , Sorokin A. A.
Published: January 2019

The aimwas to study of anthropometric indicators to determine the level of physical development of adolescents engaged and not involved in sports.

Material and methods.110 male athletes engaged in Sambo wrestling (average age 15.4±0.7) were examined. The study used methods of complex anthropometry and dynamometry. As the main indicators were estimated the length and weight of the body, indicators of the chest circumference and vital capacity of the lungs, the value of back and carpal dynamometry. Hand dynamometry was carried out on the device medical electronic dynamometer DMER-120-0.5. Back dynamometry was carried out on the device back dynamometer, DS-500.

Results. In the study group, about 61 % of athletes in each age group have deviations from the weight norm in accordance with the Broca index. Despite active physical activity, about 30 % of the surveyed, in each age group, have a medium or weak physique. The tendency towards weight loss may be due to excessive exercise or insufficient nutrition and recovery.

Conclusion. There is a decrease in the values of weight-growth indices, which indicate non-compliance with the basic principles (balance, adequacy) of the nutrition system, as the main part of the system of recovery of the young athlete and require a revision of approaches to the diet of Sambo athletes.
The Morphometric Characteristic of the Acetabulum and Some Structures of the Hip Joint in 18–22 Weeks of Fetus Development
Authors: Gulina Yu. V. , Lyashchenko D. N.
Published: January 2019

The purposeof the study is to obtain new quantitative morphometric data on the anatomy of the acetabulum, femoral head and femoral head ligament in 18–22 weeks of fetus development.

Materials and methods.The object of the research were 30 human fetuses 20–22 weeks of development, obtained in artificial abortion according to the social reasons. We used a set of morphological techniques: macromicroscopic preparation, a method of cuts according to N. I. Pirogov, preparing of serial histotopograms, morphometry and a method of statistical analysis. All samples were divided into three age groups: 18–19 weeks, 20–21 weeks and 22 week.

Results. New quantitative morphometric data of the main parameters of the acetabulum, femoral head and its ligament in human fetuses with the age interval of 2 weeks were obtained. Based on the analysis of the data, it was found that at the period from 18 to 22 weeks of development, the vertical diameter of the acetabulum is larger than the horizontal one; the depth of the acetabulum changes with less intensity than the diameters. A wide range of absolute values of the parameters studied, as well as the difference in the degree of ossification of the acetabulum, suggest the presence of individual features of development. Changes in the diameters of the femoral head correlate with changes in the acetabulum itself. Significant asymmetry and sexual dimorphism of these structures have not been identified.

Conclusion. It was revealed that in the period of 18–22 weeks of development, the formation of the anatomy of the acetabulum is actively underway. The dynamics of change of quantitative parameters of the hip joint structures has the character of a uniform increase over the period studied. In addition, the results of the work suggest the presence of individual features of the anatomy of the acetabulum of the fetus.
Anthropometric Markers of Postmenopausal Bone Mineralization Disorders
Authors: Pashkova I. G.
Published: January 2019

Thepurposeof the study was to identify anthropometric factors determining the state of bone mineral density in lumbar vertebrae in postmenopausal women.

Material and methods. Anthropometry was used to determine the component composition of the body in 191 postmenopausal women aged 43 to 84 years. Bone mineral density of lumbar vertebrae was assessed by x-ray densitometry. Correlation analysis was carried out to identify the relationship between the studied parameters.

Results. The frequency of occurrence of mineral density disorders of lumbar vertebrae was 63.4%, including osteopenia – 40.3%, osteoporosis – 23.1%. In persons with overweight and obesity, osteopenia was more often recorded (2.2 and 4 times, respectively), in women with normal body weight, osteoporosis was more frequent (1.2 times). Values of anthropometric parameters and component composition of the body were statistically significantly lower in women with osteopenia and osteoporosis.

Conclusion. It was found that the anthropometric markers determining the mineral density of bone tissue of lumbar vertebrae in postmenopausal women may be body weight, body mass index, body surface area, muscle mass and fat mass.
Doublecortin Expression in the Olfactory Bulb and Rostral Stream in Infantile Rats after Exposure to Neurotoxin
Authors: Pozhilov D. A. , Rumyantseva T. A. , Varentsov V. E. , Moskalenko A. V.
Published: January 2019

The aim of the study was to investigate changes of neuroblasts’ numeral destiny in rats’ olfactory bulb and rostral migratory stream after neurotoxic action in infant age.

Material and methods. The distribution of DCX, a marker of immature neurons, was studied to reveal the dynamics of its expression in the evolutionary period of ontogenesis in olfactory bulbs and rostral migratory stream in 30, 60, 90, and 180-day-old rats. Modeling of neurotoxic effects was carried out by three times injections of capsaicin on the 30–32 day of life in a total dose of 120 mg/kg. The material for the study was sampled on the 15-, 30- and 60th days of the experiment. The marker was detected on parasagittal paraffin sections, taking into account the layers of the olfactory bulb. The numerical density of DCX+ neurons (pcs/mm2) and their part in the total number of cells were determined.

Results. The standard age indicators of the numerical density of immature neurons and their share in the cell population, as well as similar indicators for two months after toxic effects, were established. The administration of toxic doses of capsaicin causes a massive death of mature neurons. Compensatory reaction manifested by activation of neurogenesis in the brain stem niches and an increase in the numerical density neuroblasts in the rostral stream.

Conclusions. Activation of neurogenesis during neurodegeneration causes an increase in the number of DCX + neuronal progenitors in the olfactory bulb after 30 days after exposure and maintaining high levels until the end of observation.
Features of the Structure of Cerebral Vessels in Persons who Died from Rupture of Cerebral Artery Aneurysm
Authors: Trushel' N. A. , Nechipurenko N. I. , Sidorovich R. R. , Zmachinskaya O. L. , Bokhan I. V.
Published: January 2019

The aimof the study is to define of variants of the Willi’s circle and also structural features of the vessel walls at the site of aneurysm location in people who died from aneurysms in the dead from their rupture to identify risk groups for cerebrovascular disease.

Material and methods.The structure of cerebral vessels of 8 people at the age from 17 to 69 of both sexes who died from subarachnoid hemorrhage of aneurysmal genesis was examined due to macro-microscopical and clinical methods. Histology slides of cerebral arterial walls of aneurysm area were stained with hematoxylin-eosin and Mallory’s technique and then were examined.

Results. Variants of the Willi’s circle and morphological features of vessel walls located in aneurysm formation area in people who died from aneurysm rupture are shown in the article

Conclusion. Not classic variants of Willi’s circle, fibromuscular dysplasia of the medial type and atherosclerotic changes of vessel walls contributes to aneurysm occurrence in cerebral vessels.
Analysis of Tumor Volume Dynamics in Colorectal Cancer
Authors: Filin A. A. , Sizov A. A. , Chupandina E. E. , Danilenko V. I. , Bugrimov D. Yu. , Polupanova K. G.
Published: January 2019

The purposeof the study was to investigate the dynamics of tumor volume change in different age groups and its relation to the clinical (sex, age, stage of disease, life expectancy) and morphological parameters (tumor localization, metastases to regional lymph nodes, tumor invasion depth, histological type and degree of differentiation).

Material and methods.The data of 527 patients (men and women, age from 24 to 86 years) suffering from colorectal cancer who underwent primary resection of the tumor. Clinical data and protocols of pathologist were analyzed: clinical stage of the disease, tumor localization, life expectancy, macroscopic, microscopic description, diagnosis. Based on the data obtained from the gross description, the tumor volume was calculated.

Results. The maximum incidence of colorectal cancer was observed in patients in the age group from 70 to 79 years, more than 90% of all patients are over 50 years old. The volume of the tumor in colorectal cancer varied significantly, but the dynamics of the increase of the average volume with age was not observed. Opposite, the largest neoplasms were found in the youngest patients.

Conclusion. Obtained data shows that changes in the tumor volume in colorectal cancer is nonlinear. Indicators of tumor volume in different age groups show similar dynamics: the most common tumors are mediumsized, but the small and very large tumors are much less common, which can explain the low rates of detection of tumors of this localization in the early stages.
An Update on Known Rare Rhnull Phenotype Individuals in Iran
Authors: Shahverdi Ehsan , Baschin Marcel , Moghaddam Mostafa
Published: January 2019

the article's abstract is no available.
T-Cell B-Rich Lymphoma Presenting as Renal Colic with Positivity of CD3
Authors: Nabil Al Houri Hasan , Younes Ahmad Tagrid , Zaher Adden Sarah , Hikmat Assad Wisam , Raiy Ammar
Published: January 2019

T-Cell Rich B-Cell Lymphoma (TCRBCL) is relatively a new entity, lately classified as a morphologic variant of Diffuse Large B-cell lymphomas (DLBCL). It consists (1-3) % of all B-cell lymphomas. The rate is far less when describing cases of primary splenic involvement with TCRBCL. Pathologically, TCRBCL is described as a limited number of scattered, large, atypical b-cells embedded in a background of abundant t-cells and frequently histiocytes. The similarity of this malignancy with other types makes it difficult to distinguish between them. Thus, it needs expertise in both clinical and pathological fields to make the right diagnosis. Here, we present a case of an adult male patient whose first presentation and previous medical history of renal colic misguided the initial diagnosis and suggested another colic episode as the underlying ailment. However, further physical, radiological and histopathological investigations uncovered the presence of primary TCRBCL within spleen with no involvement of other sites. Moreover, unusual pathologic finding of CD3 positivity was proved by immunohistochemistry.
Long-Term Remission of Acquired von-Willebrand's Disease and Platelet Dysfunction after High-Dose Melphalan in a Patient with Multiple Myeloma
Authors: Stratmann Jan , Gundermann Stefan , Geisen Christof , Dukat Alexandra , Miesbach Wolfgang
Published: January 2019

Background: Autologous stem cell transplantation is considered a standard of care treatment in eligible patients with multiple myeloma, but puts the patient at high risk for infections and bleeding complications. Acquired von-Willebrand's disease (AVWD) and acquired platelet dysfunction are rare bleeding disorders that are associated with lymphoproliferative disorders such as multiple myeloma. Patients with acquired bleeding disorders who are planned for ASCT to treat the underlying condition are considered at highest risk for bleeding complications, and optimal treatment strategies are not known.
Materials and Methods: We summarized the diagnostic and therapeutic approach to a patient affected by AVWD and acquired platelet disorder related to multiple myeloma. The patient who was planned for ASCT presented with moderate to severe bleeding symptoms.
Results: Acute bleeding episodes were successfully controlled and prevented during induction and consolidation therapy with immunoglobulins, whereas replacement of plasma-derived VW factor showed no clinical improvement. High-dose melphalan-based consolidation therapy supported with autologous stem-cell transplantation led to an immediate and sustainable rise of von-Willebrand antigen and activity and a subsequent normalization of platelet aggregation activity. After a follow-up of 40 weeks, the patient maintained normalized VW levels and platelet aggregation capacity. There were no further signs or symptoms of bleeding.
Conclusion: This case report highlights the necessity for combined supportive and causal treatment in patients with AVWD and paraproteinemic PD. High-dose melphalan with autologous stem cell support may function as a treatment option in patients with myeloma-related AVWD.
Capacidades Dinâmicas e Internacionalização da Inovação: O Caso Siemens Brasil
Authors: Limongi França Antonio de Sant'Anna , Maccari Emerson Antonio , Costa Priscila Rezende Da
Published: January 2019

O objetivo geral foi analisar como o processo de desenvolvimento de capacidades dinâmicas pode ser potencializado pelas práticas de internacionalização da inovação que incluem, especificamente: (a) a autonomia em P&D concedida à subsidiária de uma multinacional, (b) as atribuições tecnológicas delegadas à subsidiária de uma multinacional, (c) a transferência reversa de ativos do conhecimento da subsidiária para a matriz e demais subsidiárias estrangeiras de uma multinacional e (d) a ambidesteridade (funções de adaptação e alinhamento) exercida pela subsidiária de uma multinacional. Para tal, foi realizada uma pesquisa qualitativa e adotou-se como método o estudo do caso da Siemens Brasil. De forma específica, analisou-se em profundidade os mecanismos e interfaces do desenvolvimento das seguintes inovações da Siemens Brasil: (1) Transformador Subterrâneo a Seco DrySub, (2) Sistema Smart Grid de gestão de energia, (3) Sistema de Posicionamento Dinâmico de Plataformas Marítimas e (4) Contatores Digitais. Os achados da pesquisa revelam contribuições científicas relevantes no que tange à compreensão dos fundamentos e dos processos chave da capacidade dinâmica de desenvolvimento tecnológico local de uma subsidiária, bem como as sinergias perante às práticas de internacionalização da inovação de uma multinacional.
Fatores Relacionados a Internacionalização das Redes de Franquias Brasileiras: Dispersão Geográfica e Pertencimento a Grupos
Authors: Bretas Vanessa Pilla , Galetti Jefferson Ricardo , Rocha Thelma Valéria
Published: January 2019

Este artigo investiga os fatores que explicam o baixo índice de internacionalização das redes de franquias brasileiras. O objetivo é identificar se por um lado os recursos da empresa, como experiência de monitoramento, dispersão geográfica no mercado doméstico e reputação, e, por outro, aspectos institucionais, como pertencimento a grupos empresariais, influenciam a probabilidade das redes de franquias brasileiras se internacionalizarem. Utilizando dados secundários disponibilizados pela Associação Brasileira de Franchising (ABF), são investigados as relações entre quatro aspectos influenciadores e as chances de internacionalização por meio de uma regressão logística para uma base de 420 redes de franquias brasileiras, sendo 49 dessas internacionalizadas e 371 não internacionalizadas. Os resultados confirmaram as hipóteses relacionadas à dispersão geográfica nacional, franqueadores com maior dispersão geográfica no mercado doméstico estão mais propensos a se internacionalizarem, e pertencimento a grupos, franqueadores que pertencem a grupos estão mais propensos a se internacionalizarem. Como contribuição, este estudo inova ao comprovar quantitativamente que a dispersão geográfica nacional, e pertencer a grupos são fatores que determinam a internacionalização de redes  franquia de mercados emergentes, como o Brasil.
The Marketing Mix in a Marketing 3.0 Context
Authors: Warrink Dennis
Published: January 2019

Modern society is becoming increasingly aware of the necessity to behave sustainably which resulted in higher expectations towards sustainable practices of businesses. Thus, Marketing 3.0, a concept developed by Kotler, Kartajaya, and Setiawan (2010) which takes a more sustainable approach towards marketing, received an increasing amount of attention in the academic and practical world. This paper, therefore, identified the various influences this new marketing era has on the widely known and accepted 7P Marketing Mix to provide a valuable literature basis for the effect of Marketing 3.0 on marketing practices in the form of an in-depth literature review. Furthermore, an evaluation of ethical issues regarding the new marketing era is presented with the aim of receiving a comprehensive and critical overview of this new emerging topic. The use of Marketing 3.0 practices is expected to generate benefits for customers and companies simultaneously by creating a more sustainable and making the world a better place. The efficient use Marketing 3.0 also aims to result in higher consumer trust through the use of collaboration practices. Moreover, findings suggest that Marketing 3.0 highly impacts six out of the seven Marketing Mix Ps, namely product, price, promotion, process, people, and physical evidence, as well as mildly influences place. Therefore, the concept of Marketing 3.0 is a crucial extension of current marketing practices by providing economic profits, while at the same time taking into consideration environmental, ethical, and social factors.
Role Conflict and Role Ambiguity Impact on Collective Efficacy – towards Team Cohesion
Authors: Cevik Ilkay , Wang Bin
Published: January 2019

This study attempts to investigate the relationship between Collective Efficacy and Team Cohesion in the performance of youth football teams in France. Also, we are going to examine the influence of role ambiguity and role conflict on collective-efficacy. Furthermore, we will evaluate the significance of collective-efficacy impacting team cohesion and will provide a deeper insight into the study of French football teams. Moreover, the goal was also to describe and specify the profile of the questionnaire respondents that were included in the study and indicated why they were selected in the data collection process. Role ambiguity was found to be significant in affecting the players’ perception of efficacy but in a positive way. However, that contradicts to our theoretical assumption, stating that role ambiguity has a negative impact on collective efficacy. Individual perceptions of the players’ regarding their role do not seem to change the collective perception, taking into account the ambiguity factor. The sample of young football shows that there is a limited number of studies on this relationship among this age group. Therefore, it can be tested as a moderating factor of forming efficacy-cohesion relationship and more research should be provided in this topic, as it is new in contemporary studies.
Kompetensi Manajerial Kepala Sekolah Dalam Mengembangkan Pendidikan Agama Islam Berwawasan Multikultural
Authors: Fauziah Nur
Published: January 2019

The purpose of this study was to describe and analyze about: 1) Principal planning in developing multicultural Islamic religious education in the 1 Kademangan Vocational High School (SMKN). 2) The process of organizing school principals in applying multicultural Islamic religious education at 1 Kademangan Vocational High School. 3) Implementation Procedure of the principal in developing multicultural Islamic religious education at 1 Kademangan Vocational High School. 4) Control of principals in developing multicultural Islamic religious education in 1 Kademangan Vocational High School. The type of research conducted is qualitative research with a qualitative descriptive approach. This study focuses on managerial competencies of principals in developing multicultural Islamic religious education in 1 Kademangan Vocational High School. For data collection techniques, researchers conduct interviews, documentation and direct observation. While the analysis of the data used in this study is the data analysis technique of the Spradley model or better known as Cyclic mode. The results found by researchers in the field are planning processes, goals must be made clearly because it is used as a guideline for activities that reinforce the direction and effort of activities and facilitate in obtaining the support of resources and competencies in both the organization and the environment. Organizing is organized on the basis of predetermined objectives and formal formal mechanisms in the organizational structure that reflect the needs and optimization of existing resources in a good organization. At the stage of implementing the communication skills of the school principal also determines the course of effective management. The supervision process becomes an important part that is directly related to considering changes in procedures, policies, and even organizational goals.
Strategi Kepala Madrasah dalam Peningkatan Kompetensi Tenaga Pendidik dan Kependidikan di Madrasah Tsanawiyah
Authors: Sa'adah Nur Lailatus
Published: January 2019

The head of the madrasa is the leader of educational institutions responsible for the management of educational institutions such as educational activities, madrasa administration, fostering teaching and education staff, and utilization and maintenance of facilities and infrastructure. The purpose of this study is to find out and describe: in increasing the competence of educators and education staff, 2) The process of implementing the principal's strategy in improving the competence of educators and education staff. 3) The implications of implementing the program enhance the competence of educators and education staff. This type of research is qualitative research with a descriptive approach. For data collection techniques, researchers conduct interviews, documentation and direct observation. Meanwhile, to confirm, researchers used data triangulation techniques. The results found by researchers in the field are: 1) The strategy process carried out by the head of the madrasah by observing the needs of educators and education, planning the implementation of the program, evaluating the planned program, 2) The process of implementing the program, namely the head of the madrasa prepares a program in the form of seminars, workshops, training, technical guidance and training in the workplace, 3) Impacts obtained by program participants are increased knowledge, increased skills possessed and having connections outside of educational institutions.
Manajemen Pembiayaan Bantuan Operasional Sekolah Dalam Meningkatkan Mutu Pendidikan Pondok Pesantren
Authors: Mazidah Siti
Published: January 2019

Financing is one of the keys to implementing an education. One source of funding sourced from the government is the School Operational Assistance (BOS) program. The purpose of this study was to: (1) describe the distribution of BOS funds in the education of Islamic boarding schools in the Ministry of Religion Office in Malang Regency, (2) explain the supervision of BOS funding in Islamic boarding school education, (3) describe the implications of BOS funding in improving quality Islamic boarding school education. This study uses a qualitative approach with a type of case study research. Data collection techniques used were observation, interviews, and documentation. Data is analyzed by reducing relevant data, describing and drawing conclusions. The results showed that, (1) the distribution of funding for BOS funds in the education of Islamic boarding schools in the Malang Ministry of Religion Office was carried out in accordance with the flow, (2) supervision of BOS funding in improving the quality of Islamic boarding school education was carried out according to the time of disbursement at the time of reporting of BOS funds, namely by direct and indirect supervision, (3) Implications of BOS funds in improving the education quality of Islamic boarding schools, namely: improving student achievement and learning outcomes and increasing teacher welfare.
PENGEMBANGAN METODOLOGI PEMBELAJARAN PAI MELALUI TEORI PEMROSESAN INFORMASI DAN TEORI NEUROSCIENCE
Authors: Suprapto Anas
Published: January 2019

his article examines the development of Islamic education learning methodology with two theories, namely the theory of information processing and neuroscience theory. The article concludes that the development of Islamic education learning methodology through the first theory is done by the teacher should present PAI learning materials in a creative and interesting, so that students will be stimulated and liked the material taught by the teacher. Meanwhile, with the second theory done by means teachers must first know and understand the performance of the human brain, after that then, PAI teacher can use a variety of learning models of Islamic education attractive to students or learners. Both of these theories have great benefits for the learning of Islamic education that had been there
POLITIK DAN PENDIDIKAN (Tinjauan Historis Pengaruh Kebijakan Politik Terhadap Sistem Pendidikan di Indonesia)
Authors: Asrori Mohammad
Published: January 2019

Problems of education in Indonesia is the product of political interest of ruler, therefore they use it as a tool of authority. Education as subsystem of the state has function as supplier of educated people, it can succeed in development. In this beloved country, the reality of problems in education can not be separated from the effort to gain the authority. Therefore, educations sector is the medium for the success of the policy to achieve the goal and principal aspiration its leadership
PENGEMBANGAN MAHÂRAH KALÂM DENGAN STRATEGI BERMAIN PERAN (ROLE PLAY) BAGI SANTRI MA’HAD NURUL HUDA MAN TLOGO BLITAR
Authors: Rusyadi Refki
Published: January 2019

Second language (Arabic) learning, focused on optimizing speaking skill with appropriate oral communication style is challenging. This phenomenon inextricably has initiated myriad of innovative methods and strategies to improve speaking skill effectively and efficiently in the schools across Indonesia. Besides, those methods and strategies can be a means of maintaining interactive atmosphere in the classroom. One of the adequate strategies is role play. In the form of play or drama instructional activities, the teachers can help students enhance their speaking skill by naturally interacting in the classroom so as to produce well appropriate expression. For broader aspect, role play as one of cooperative language learning can foster the students’ character building in its own dimension.
MODEL PEMBELAJARAN PENDIDIKAN AGAMA ISLAM BERWAWASAN MULTIKULTURAL: STUDI PADA GURU PENDIDIKAN AGAMA ISLAM MTSN TAMBAK BERAS JOMBANG
Authors: Asrori Mohammad
Published: January 2019

As a country endowed with a multifaceted cultural wealth and tribes and nations, the study of multicultural education and religion is an inseparable unity. One place that is quite representative in seeing learning model multicultural vision of Islam is MTSN Tambak Beras Jombang. Pesantren-based Madrasah has long run a multicultural vision of Islamic religious education though is not formally written into the curriculum developed. Islamic religious education in a multicultural vision of MTSN Tambak Beras Jombang become one of the important features in fostering the values of social pluralism in a nation and a state without losing the values of Islamic