bluuebunny/crossref_metadata_2025 huggingface dataset:
Siblings of Individuals with Disabilities: Experiences in Southern India
Authors: Dickinson Rebecca
Published: October 2020

This exploratory qualitative study explores the experiences of the siblings of individuals with disabilities in Southern India. Five siblings of students attending one special school were recruited to participate in the study using the method of auto-photography. Participants were asked to take photographs of what it is like to have a sibling with a disability. Grounded theory was utilized in the qualitative analysis of transcribed interviews processing the photographs. Participants endorsed six positive themes. Cultural and religious misperceptions of disabilities and subsequent themes of shame and rejection were not found. The findings of this study found positive experiences of siblings of people with disabilities and may provide tentative support for local anecdotal reports of increased acceptance of people with disabilities, opening the door to future research opportunities in this area.
Long-Term Nonclinical Pulmonary Safety Assessment of Afrezza, a Novel Insulin Inhalation Powder
Authors: Greene Stephanie F. , Nikula Kristen J. , Poulin Dominic , McInally Kevin , Reynolds Jack A.
Published: October 2020

Afrezza delivers inhaled insulin using the Gen2 inhaler for the treatment of patients with type 1 and type 2 Diabetes. Afrezza was evaluated in long-term nonclinical pulmonary safety studies in 2 toxicology species. Chronic inhalation toxicology studies in rat (26 weeks) and dog (39 weeks) and an inhalation carcinogenicity study in rats were conducted with Technosphere insulin (Afrezza) and with Technosphere alone as a vehicle control. Respiratory tract tissues were evaluated by histopathology and cells expressing proliferating cell nuclear antigen (PCNA) were quantified in lungs of rats. Microscopic findings in rats exposed to Afrezza were attributed to the Technosphere particle component, were confined to nasal epithelia, and consisted of eosinophilic globules and nasal epithelial degeneration. There were no Afrezza-related changes in pulmonary PCNA labeling indices in alveoli, large bronchioles, or terminal bronchioles. Microscopic findings in rats exposed to Technosphere particles included eosinophilic globules, mucus cell hyperplasia, and epithelial degeneration in the nasal cavities. PCNA labeling indices were increased in large bronchioles and terminal bronchioles but not in alveoli. There were no Technosphere particle-related findings in the dog study. Afrezza did not exhibit carcinogenic potential in the 2-year study in rats. These nonclinical inhalation studies support the use of Afrezza in humans over extended periods.
Opinion on Performing Pathology Peer-Review During the Global Pandemic: Challenges and Opportunities
Authors: Hukkanen Renee R. , Irizarry Armando , Fikes James D. , Schafer Kenneth A. , Boyle Molly H.
Published: October 2020

The coronavirus disease 2019 pandemic has affected business on numerous fronts in unprecedented and abrupt ways. From site closures and local “stay-at-home orders” to travel advisories and restrictions, the day-to-day practice of toxicologic pathology has been impacted dramatically and rapidly. A critical function of Toxicologic Pathologists is performing pathology peer review for nonclinical studies. Traditionally, corroborating the findings of histological assessment could be achieved through shipment of histopathological slides to the peer review pathologist, or by the peer review pathologist traveling to the location of the slides (eg, the test facility). Since early 2020, many pathologists have been unable to perform the latter due to local, regional, national, test facility, company, and/or personal restrictions. The disruption for some has been minimal, while others are working from home for the first time. We recommend that contingency plans for all peer review procedures and personnel should be in-place to accommodate sudden and unexpected workflow transitions. Now, more than ever, approaching peer reviews with enhanced adaptability will help ensure success.
Food and nutrient provision in preschools: Comparison of public and private preschools
Authors: Yen Chin-En
Published: October 2020

Background:

A balanced diet is important for ensuring health and development in childhood. As preschool is the main place of childcare, the meals that they provide have a critical influence on children’s dietary intake.

Aim:

The objectives of this study were to evaluate the nutrition status of preschool meals and to compare the food and nutrient content in public and private preschool meals.

Methods:

This was a cross-sectional study of 12 randomly sampled, public and private preschools in Taichung City, Taiwan. The background questionnaires, which included the meal budget and provision status of preschool meals, were completed either by the principals or supervisors of the preschools. The food and nutrition levels of preschool meals were assessed by weighing the actual food provided to the preschool children. In addition, preschool menus were collected to evaluate the meals and food served.

Results:

Overall, the mean calcium provision of preschools was lower than half the daily dietary reference intake (DRI), and the mean sodium was higher than half the DRI. The mean energy, carbohydrate, protein, fat, iron and vitamins B1, B2 and C supplied by the public preschools were significantly higher than those in the private preschools. In addition, the whole grains, meat, vegetables, fruits, oil and nuts supplied in public preschools were significantly higher than those found in private preschools.

Conclusions:

The mean energy and macronutrient provision of public preschools were significantly higher than those found in private preschools. Meal quality and nutrient levels offered in public preschools were generally higher than those found in private preschools.
“Mom, dad, look at me”: The development of the Parental Phubbing Scale
Authors: Pancani Luca , Gerosa Tiziano , Gui Marco , Riva Paolo
Published: October 2020

The widespread diffusion of smartphones has opened new challenges regarding the psychological consequences of their usage on social relationships. The term phubbing (a combination of phone and snubbing) indicates the act of ignoring someone in a social context by paying attention to the smartphone. The few existing studies show that phubbing is widespread, mutually reinforced, and socially accepted, with possible negative consequences for social and individual well-being. Phubbing can occur in every social context, including romantic relationships, workplaces, and family. However, to date, minimal attention has been given to the possible impact that phubbing carried out by parents can have on their children. To start filling this gap, in this paper, we introduced a new scale that measures the perception of being subject to parental phubbing and showed the prevalence of perceived phubbing on a stratified sample of 3,289 adolescents. Firstly, the dimensionality, validity, and invariance of the construct were proven. Moreover, our results showed a positive relationship between children’s perceived levels of parental phubbing and their feelings of social disconnection with parents, thus suggesting that the more children felt that one or both of their parents were phubbing them, the less the children felt connected with their parents.
A comparative evaluation of telehealth and direct assessment when screening for spasticity in residents of two long-term care facilities
Authors: Harper Kelly A , Butler Emily C , Hacker Mallory L , Naik Aaditi , Eoff Bryan R , Phibbs Fenna T , Isaacs David A , Gallion Stephen J , Thomas Esmeralda P , Scott Jim L , Ploucher Shelby , Meystedt Jacqueline C , McLeod Megan E , Charles Philip David
Published: October 2020

Objective:

To evaluate the performance of telehealth as a screening tool for spasticity compared to direct patient assessment in the long-term care setting.

Design:

Cross-sectional, observational study.

Setting:

Two long-term care facilities: a 140-bed veterans’ home and a 44-bed state home for individuals with intellectual and developmental disabilities.

Subjects:

Sixty-one adult residents of two long-term care facilities (aged 70.1 ± 16.2 years) were included in this analysis. Spasticity was identified in 43% of subjects (Modified Ashworth Scale rating mode = 2). Contributing diagnoses included traumatic brain injury, spinal cord injury, birth trauma, stroke, cerebral palsy, and multiple sclerosis.

Main measures:

Movement disorders neurologists conducted in-person examinations to determine whether spasticity was present (reference standard) and also evaluated subjects with spasticity using the Modified Ashworth Scale. Telehealth screening examinations, facilitated by a bedside nurse, were conducted remotely by two teleneurologists using a three-question screening tool. Telehealth screening determinations of spasticity were compared to the reference standard determination to calculate sensitivity, specificity, and the area under the curve (AUC) in receiver operating characteristics. Teleneurologist agreement was evaluated using Cohen’s kappa.

Results:

Teleneurologist 1 had a specificity of 89% and sensitivity of 65% to identify the likely presence of spasticity ( n = 61; AUC = 0.770). Teleneurologist 2 showed 100% specificity and 82% sensitivity ( n = 16; AUC = 0.909). There was almost perfect agreement between the two examiners at 94% (kappa = 0.875, 95% CI: 0.640–1.000).

Conclusion:

Telehealth may provide a useful, efficient method of identifying residents of long-term care facilities that likely need referral for spasticity evaluation.
Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial
Authors: Lindsay Cameron , Ispoglou Sissi , Helliwell Brinton , Hicklin Dawn , Sturman Steve , Pandyan Anand
Published: October 2020

Objective:

Does early treatment of spasticity with botulinum-toxin (BoNTA), in (hyper)acute stroke patients without arm-function, reduce contractures and improve function.

Design:

Randomised placebo-controlled-trial

Setting:

Specialised stroke-unit.

Participants & Intervention:

Patients with an Action Research Arm Test (ARAT) grasp-score⩽2 who developed spasticity within six-weeks of a first stroke were randomised to receive injections of: 0.9%sodium-chloride solution (placebo) or onabotulinumtoxin-A (treatment).

Outcome-Measures:

Spasticity, contractures, splint use and arm function (ARAT) were taken at baseline, 12-weeks post-injection and six-months after stroke. Additionally, spasticity and contractures were measured at weeks-two, four and six post-injection.

Results:

Ninety three patients were randomised. Mean time to intervention was 18-days (standard deviation = 9.3). Spasticity was lower in the treatment group with difference being significant between week-2 to 12 (elbow) and week-2 to 6 (wrist). Mean-difference (MD) varied between –8.5(95% CI –17 to 0) to –9.4(95% CI –14 to –5) µV. Contracture formation was slower in the treatment group. Passive range of motion was higher in the treatment group and was significant at week-12 (elbow MD6.6 (95% CI –0.7 to –12.6)) and week-6 (wrist MD11.8 (95% CI 3.8 to 19.8)). The use of splints was lower in the treatment group odds ratio was 7.2 (95% CI 1.5 to 34.1) and 4.2 (95% CI 1.3 to 14.0) at week-12 and month-6 respectively. Arm-function was not significantly different between the groups MD2.4 (95% CI –5.3 to 10.1) and 2.9 (95% CI –5.8 to 11.6) at week-12 and month-6 respectively.

Conclusion:

BoNTA reduced spasticity and contractures after stroke and effects lasted for approximately 12-weeks. BoNTA reduced the need for concomitant contracture treatment and did not interfere with recovery of arm function.

Trial Registration:

EudraCT (2010-021257-39) and ClinicalTrials.gov-Identifier: NCT01882556.
Marker-less assessment of the geometric error of fused cone-beam computed tomography images of the foot constructed using stitching software
Authors: Wellenberg Ruud HH , Dobbe Johannes GG , Erkkilä Jukka , Maas Mario , Streekstra Geert J
Published: October 2020

Background

Image noise, object repositioning, initial manual image alignment, and stitching of different volumes, i.e. anatomical regions may all affect the stitching error of fused cone-beam computed tomography (CBCT) images.

Purpose

To determine the geometric error of fused CBCT images of the hindfoot, lower leg, and forefoot after using stitching software, based on a marker-less validation method.

Material and Methods

CBCT images of the hindfoot, lower leg, and forefoot were acquired multiple times on a Planmed Verity scanner with and without repositioning the leg between acquisitions. Prototype stitching software was used to stitch hindfoot–forefoot volumes and hindfoot–lower leg volumes. Stitching error was determined via registration and by calculating the displacement of the tibia, first metatarsal, or proximal phalanges, with respect to the calcaneus, compared to their position on conventional CT.

Results

Overall total translation and rotation errors were 1.22 ± 0.62 mm (range 0.43–3.07 mm) and 1.27° ± 0.53° (range 0.29°–2.88°). Lower leg translation was smaller compared to forefoot translation ( P < 0.001). No statistical difference was observed between lower leg and forefoot rotation errors ( P = 0.186). Cadaver repositioning between acquisitions resulted in larger rotation errors ( P < 0.05). Cadaver repositioning did not affect translation errors ( P = 0.768).

Conclusion

Geometric error of fused CBCT images can be quantified using a marker-less validation method. Stitching of hindfoot volumes with forefoot and lower leg volumes induces translation and rotation errors of up to approximately 3 mm and 3°. Translation errors are larger in hindfoot–forefoot stitches compared to hindfoot–lower leg stitches.
Imaging of bioluminescent Klebsiella pneumoniae induced pulmonary infection in an immunosuppressed mouse model
Authors: Hu Xing , Cai Yun , Wang Yuhang , Wang Rui , Wang Jin , Zhang Bo
Published: October 2020

Objective

To establish a mouse model of bioluminescent Klebsiella pneumoniae-induced lung infection, under different infection states after pretreatment with various dosages of cyclophosphamide (CTX).

Methods

A K. pneumoniae strain carrying the luxCDABE operon was used to infect immunocompetent mice (intraperitoneal injection of saline at 4 days and 1 day prior to experimental lung infection) and immunodeficient mice (50 mg/kg CTX at 4 days and 50 mg/kg CTX at 1 day prior to lung infection; or 150 mg/kg CTX at 4 days and 100 mg/kg CTX at 1 day prior to lung infection). Disease progression was monitored in living mice using a bioluminescence imaging system. The bioluminescent images, bacterial loads in lungs, blood cytological changes and histopathology of lungs were analysed.

Results

K. pneumoniae-induced lung infection models were established in mice pretreated with CTX. Different doses of CTX led to different severities of lung infection. Mice pretreated with 150/100 mg/kg CTX were more suitable for real-time monitoring as they had more typical bioluminescent images of lung infection, more obvious changes in the bioluminescent intensity values, more bacterial colonies in the lungs and more distinct pulmonary pathological changes.

Conclusions

A stable bioluminescent K. pneumonia-induced lung infection model was successfully established in mice pretreated with CTX, which can be semi-quantitatively monitored in real-time.
Risk factors for early postoperative recurrence in single and small hepatitis B virus-associated primary hepatocellular carcinoma
Authors: Jin Hongmei , Wang Hui , Li Guanghao , Hou Qingshun , Wu Wei , Liu Fuhui
Published: October 2020

Objective

To investigate the risk factors of early postoperative recurrence in patients with single and small (≤3 cm) hepatitis B virus-associated primary hepatocellular carcinoma (HBV-HCC).

Methods

This retrospective study analyzed patients with single and small HBV-HCC. All patients were followed up for 1 year after surgery.

Results

Among 182 patients, 54 patients had early recurrence within 1 year. The recurrence group had higher proportions of men, drinking history, Child–Turcotte–Pugh (CTP) class C, patients who underwent transarterial chemoembolization (TACE), and serum alpha-fetoprotein (AFP) >10 ng/mL as well as higher gamma-glutamyl transpeptidase (GGT) levels and lower total protein (TP) and CD8+ T lymphocyte levels than the no recurrence group. Cox multivariate regression analysis demonstrated that drinking history (HR, 1.312; 95% CI, 1.042–1.652), CTP class C (HR, 1.236; 95% CI, 1.037–1.473), TACE treatment (HR, 1.241; 95% CI, 1.026–1.501), GGT (HR, 1.138; 95% CI, 1.042–1.243), TP (HR, 0.729; 95% CI, 0.555–0.957), and AFP (HR, 2.519; 95% CI, 1.343–4.726) were independently associated with early postoperative recurrence.

Conclusion

Drinking history, CTP class C, TACE, serum AFP, GGT, and TP levels were independently associated with early postoperative recurrence in patients with single and small HBV-HCC.
Cardiac contractility modulation attenuates structural and electrical remodeling in a chronic heart failure rabbit model
Authors: Ning Bin , Zhang Feifei , Song Xuelian , Hao Qingqing , Li Yingxiao , Li Rong , Dang Yi
Published: October 2020

Background

Cardiac contractility modulation (CCM) is non-excitatory electrical stimulation for improving cardiac function. This study aimed to evaluate the effects of CCM on structural and electrical remodeling in a rabbit model of chronic heart failure (CHF).

Methods

Thirty rabbits were randomly divided into the sham, CHF, and CCM groups. The CHF model was induced 12 weeks after trans-aortic constriction by pressure unloading and CCM was delivered to the myocardium for 4 weeks. Corrected QT intervals, the ventricular effective refractory period, and inducibility of ventricular tachycardia were measured by an electrophysiological examination. Connective tissue growth factor, galectin-3, Kv4.3, KCNQ1, KCNH2, and connexin 43 protein levels were measured by western blotting.

Results

The CHF group had a significantly prolonged corrected QT interval and ventricular effective refractory period, and increased inducibility of ventricular tachycardia. Prominent myocardial fibrosis and increased hydroxyproline content were observed in the CHF group, but these were suppressed in the CCM group. Kv4.3, KCNQ1, KCNH2, and connexin 43 protein levels were significantly lower in the CHF group, but treatment with CCM partially restored their levels.

Conclusions

CCM attenuates myocardial structural and electrical remodeling during CHF. These findings provide evidence for clinical use of CCM in treating CHF.
Spatial Reference Frame but Neither Age nor Gender Predict Performance on a Water-Level Task in 8- to 11-Year-Old Children
Authors: Barhorst-Cates Erica M. , Creem-Regehr Sarah H. , Stefanucci Jeanine K. , Gardner Jean , Saccomano Trish , Wright Cheryl
Published: October 2020

Successful performance on the water-level task, a common measure of spatial perception, requires adopting an environmental, rather than object-centered, spatial frame of reference. Use of this strategy has not been systematically studied in prepubertal children, a developmental period during which individual differences in spatial abilities start to emerge. In this study, children aged 8 to 11 reported their age and gender, completed a paper-and-pencil water-level task, and drew a map of their neighborhood to assess spontaneous choice of spatial frame of reference. Results showed a surprising lack of age or gender difference in water-level performance, but a significant effect of spatial frame of reference. Although they made up only a small portion of the sample, children who drew allocentric maps had the highest water-level score, with very high accuracy. These results suggest that children who adopt environmental-based reference frames when depicting their familiar environment may also use environmental-based reference frame strategies to solve spatial perception tasks, thereby facilitating highly accurate performance.
Waiting for a deus ex machina: ‘Sustainable extractives’ in a 2°C world
Authors: Rajak Dinah
Published: October 2020

In recent years the oil industry has shifted from climate change denialism to advocacy of the Paris Agreement, championing sustainability in an apparent assertion (rather than rejection) of corporate responsibility. Meanwhile growth forecasts continue unabated to finance the industry’s enthusiasm for upstream ventures in uncharted territories. How do extractive companies, and those who work in them, square this contradiction? Fieldwork among oil company executives points to a new wave of techno-optimism: a deus ex machina that will descend from the labs of corporate research and development (R&D) labs to reconcile these irreconcilable imperatives. Rather than denial, the projection of win-win synergies between growth and sustainability involves a suspension of disbelief; an instrumental faith in the miraculous power of technology that tenders salvation without forsaking fossil fuels, or restructuring markets.
Invisible children? Non-recognition, humanitarian blindness and other forms of ignorance in Sabah, Malaysia
Authors: Allerton Catherine
Published: October 2020

In the Malaysian state of Sabah, public antipathy towards the presence of large numbers of migrant workers influences a widespread ignorance of the educational and other exclusions of their children. Children of migrants are rendered invisible in Sabahan cultural discourse because they are not recognized as proper subjects, or even as ‘normal’ children. Cultural denial of such children’s circumstances can be seen in local newspaper reports that consider such children with reference to fears of ‘illegals’ and their threat to future Sabahan citizens. This discourse draws on a particular understanding of child deservingness, and utilizes what Cohen describes as ‘neutralization techniques’. However, such apparently wilful blindness can best be understood by considering it on a spectrum of different forms of ignorance and denial. This includes the blatant lack of recognition afforded by powerful individuals who should be more aware of the children of their workers, the humanitarian blindness of volunteer teachers who over-emphasize the saving power of education, and the complex and situational ignorance of children of migrants themselves. Appreciating other, potentially more benign or protective, forms of denial is crucial to understanding how ignorance of the complexity of the situation of children of migrants continues, even among those hoping to resolve it.
Melanopsin hypersensitivity dominates interictal photophobia in migraine
Authors: Zele Andrew J , Dey Ashim , Adhikari Prakash , Feigl Beatrix
Published: October 2020

Purpose

To define the melanopsin and cone luminance retinogeniculate pathway contributions to photophobia in healthy controls and migraineurs.

Methods

Healthy controls and migraineurs were categorized according to the International Classification of Headache Disorders criteria. Photophobia was measured under full-field illumination using electromyography in response to narrowband lights spanning the melanopsin and cone luminance action spectra. Migraineurs were tested during their interictal headache-free period. Melanopsin-mediated post-illumination pupil responses quantified intrinsically photosensitive Retinal Ganglion Cell (ipRGC) function.

Results

A model combining the melanopsin and cone luminance action spectra best described photophobia thresholds in controls and migraineurs; melanopsin contributions were ∼1.5× greater than cone luminance. In the illumination range causing photophobia, migraineurs had lower photophobia thresholds (∼0.55 log units; p < 0.001) and higher post-illumination pupil response amplitudes ( p = 0.03) than controls.

Conclusion

Photophobia is driven by melanopsin and cone luminance inputs to the cortex via the retino-thalamocortical pathway. In migraineurs, lower photophobia thresholds reflect hypersensitivity of ipRGC and cone luminance pathways, with the larger and prolonged post-illumination pupil response amplitude indicative of a supranormal melanopsin response. Our findings inform artificial lighting strategies incorporating luminaires with low melanopsin excitation and photopic luminance to limit the lighting conditions leading to photophobia.
‘Our befores and our afters’: Another antipodean perspective on Bernard Smith?
Authors: Gaston Robert W.
Published: October 2020

Much has been published on the career and scholarly achievements of Bernard Smith (1916–2011) since his retirement from teaching in 1977 and has predictably gathered pace after his death. It is clear that the reception of his very substantial body of writings, addressing so many fields within the humanities, critical thought and art history in particular, is only just beginning. The present study focuses on a large recent collection of Smith’s studies in which critical responses are integrated. I argue that the profoundly personal nature of historiography, necessarily incorporating praise and blame in its rhetorical structure, requires that the critic position oneself openly in relation to the life and work of the subject undergoing scrutiny. Smith’s antipodean experience was in many ways distinctive. But those of us who knew him personally, or felt his influence as a teacher and writer, will need to reassess honestly their own genesis in order to deal effectively with the challenges embedded in his work.
Investigating the Impact of Integrating Vocabulary Exercises Into an Adventure Video Game on Second Vocabulary Learning
Authors: Chen Hao-Jan Howard , Hsu Hsiao-Ling , Chen Zhi-Hong , Todd Andrew G.
Published: October 2020

Many studies have found that computer video games can offer a facilitative vocabulary learning environment. Among different types of computer games, adventure games have received much attention because of their rich input and immersive learning environment. However, some researchers have indicated that because of the characters’ fast-talking speed and many new vocabulary, more lexical supports should be provided in the games. This study thus developed an adventure game with two versions. One version was an adventure game and the other was the same game supported with vocabulary exercises. Two classes were randomly assigned to play two versions of the game and to take a pre-test, post-test, and delayed post-test. A survey was also conducted to investigate the participants’ perceptions. The results showed that both groups acquired new words, but the experimental group performed significantly better in both the immediate and delayed post-tests. These findings indicated that the adventure game alone can help participants acquire new words. However, the inclusion of word-focused exercises further helped learners retain more new words. Thus, it is suggested that game developers can incorporate word-focused exercises into video games. The additional exercise can allow learners to benefit from both implicit and explicit vocabulary learning.
A Point-Based Risk Calculator Predicting Mortality in Patients That Developed Postoperative Sepsis
Authors: Gabriel Rodney A. , Trivedi Suraj , Schmidt Ulrich H.
Published: October 2020

Background:

Predicting the mortality from post-operative sepsis remains a continuing problem. We built a statistical model using national data to predict mortality in patients who developed post-operative sepsis.

Methods:

This is a retrospective study using the American College of Surgeons National Quality Surgical Improvement Program database, in which we gathered data from adult patients between 2011 and 2016 who experienced postoperative sepsis. We designed a predictive model using multivariable logistic regression on a training set and validated the model on a separate test set.

Results:

There were 128,325 patients included in the final dataset, in which 18,499 (14.4%) died within 30-days of surgery. The model consisted of 10 covariates: American Society of Anesthesiologists Physical Status classification score, preoperative sepsis, age, chronic obstructive pulmonary disease, postoperative myocardial infarction, postoperative stroke, postoperative acute renal failure, transfusion requirement, and infection type. A point-based risk calculator was developed, which had an area under the receiver operating characteristics curve of 0.819 (95% confidence interval 0.814-0.823).

Conclusion:

Although further work is needed to confirm and validate our model on external datasets, our scoring system provides a novel way to measure mortality in septic post-operative patients.
Optimization of FDM process parameters for tensile properties of polylactic acid specimens using Taguchi design of experiment method
Authors: Heidari-Rarani M , Ezati N , Sadeghi P , Badrossamay MR
Published: October 2020

Fused deposition modeling (FDM) is the most common method for additive manufacturing of polymers, which is expanding in various engineering applications due to its ability to make complex parts readily. The mechanical properties of 3D printed parts strongly depend on the correct selection of the process parameters. In this study, the effect of three important process parameters such as infill density, printing speed and layer thickness were investigated on the tensile properties of polylactic acid (PLA) specimens. Taguchi design of experiment method is applied to reduce the number of experiments and find the optimal parameters for maximum mechanical properties, minimum weight and minimum printing time. Experimental results showed that the optimum process parameters for the modulus of elasticity and ultimate tensile strength were infill density of 80%, printing speed of 40 mm/s and layer thickness of 0.1 mm, while for the failure strain were the infill density of 80%, printing speed of 40 mm/s and layer thickness of 0.2 mm. Finally, the accuracy of the Taguchi method was assessed for prediction of mechanical properties of FDM-3D printed specimens.
A study on the filtration efficiency and regeneration capacity of the gasoline particulate filter
Authors: Yue Hongchao , Lehmen Allen , Van Nieuwstadt Michiel , Pan Zhaoxiong , Wang Jia , Fang Zhijun
Published: October 2020

Gasoline particulate filters (GPF) are becoming a standard technology in gasoline engines because of the need for compliance with particulate matter (PM) emissions requirement. Generally, GPFs can be placed after a three-way catalysts (TWC) in the same can, or in a separate can downstream. As typical wall-flow filters, particulate matter is removed from the exhaust by physical filtration using a honeycomb structure similar to an emissions catalyst substrate but with the channels blocked at alternate ends. The goal of work was to the study the filtration efficiency and regeneration capacity of the GPF. Laboratory emission tests were carried out for one 2.0L gasoline turbo direct injection (GTDI) prototype vehicle according to the new World Harmonized Light Vehicle Test Cycle (WLTC). The data showed that the vehicle has a reliable and high GPF filtration efficiency to intercept the particulate pollution from the exhaust. Meanwhile, five 2.0L GTDI prototype cars from respective China stage 6 platforms were used for further study of soot accumulation and regeneration capacity. The results, in terms of modeled emissions in tests under real driving conditions of China cities (Nanjing and Hainan), showed that the heavy traffic road conditions lead to a low probability of soot regeneration. However, the GPF regeneration capacity of the test convoy was still adequate. In addition, the drive cycle exhibiting good road conditions with more aggressive driving behaviors offered a better regeneration environment due to the elevated GPF temperature and more frequent occurrence of deceleration fuel shut off (DFSO) creating an environment of excess oxygen content.
Influence of rotor geometry on tip leakage and port flow areas in gerotor-type twin screw compressors
Authors: Read MG , Smith IK , Stosic N
Published: October 2020

Conventional twin-screw compressors are positive displacement machines that form working chambers between two helical, parallel rotors and an outer casing. This study investigates an alternative configuration of rotors for compressor applications, in which the working chambers are formed by continuous contact between meshing inner an outer rotors. This is a similar configuration to gerotor machines, which are commonly used in fuel and oil pumping applications and as hydraulic motors. For compressor applications, the use of helical rotors with appropriate porting in a gerotor-type configuration has been identified as having potentially lower rotor contact forces and larger port areas than occur with non-helical rotors. This study investigates how key performance parameters of a gerotor-type screw compressor (volume, port flow areas and tip leakage areas) are influenced by the profile, dimensions and wrap angle of the rotors. The results of this geometric analysis are compared with a conventional twin-screw compressor, and suggest that the gerotor-type screw compressor can achieve higher axial port areas and lower tip leakage area over most of the compression cycle.
Towards a methodology for new technologies assessment in aircraft operating cost
Authors: Vercella Valeria , Fioriti Marco , Viola Nicole
Published: October 2020

The need for a greener and competitive aircraft is leading to the use of new technologies. A thorough assessment of these technologies is mandatory from the initial phases of aircraft design to understand their feasibility and to select the most promising one both in terms of performances and in terms of costs. This paper proposes a methodology to assess the operating cost of innovative technologies for regional aircraft. In particular, two NASA studies have been adopted to determine the impact onto costs of MEA and AEA technologies and advanced ECS solutions for two innovative regional aircraft concepts developed during the European Clean Sky 2 research. The proposed methodology is able to assess the effect of on-board systems electrification level in terms of fuel and maintenance costs savings. The methodology, which allows to evaluate the effect of specific technological improvements onto costs, is applied exploiting the results provided by a reliable cost model and gives the opportunity to quantify operating cost savings for different regional aircraft. Applying the modified cost model to the reference aircraft under study, savings ranging from 1.6 to 3.1% of direct operating cost are estimated for MEA and AEA technologies. Greater savings are estimated for the individual cost items involved. More specifically, a reduction of fuel cost ranging from 6 to 14.5% is envisaged as a consequence of the lower SFC associated to innovative ECS technologies.
Haploidentical Hematopoietic Stem Cell Transplantation Versus Umbilical Cord Blood Transplantation in Hematologic Malignancies: A Systematic Review and Meta-Analysis
Authors: Wu Ran , Ma Liyuan
Published: October 2020

Haploidentical hematopoietic stem cell transplantation (Haplo-SCT) and umbilical cord blood transplantation (UCBT) are two important alternatives when a matched sibling donor is unavailable. Several studies have reported inconsistent clinical outcomes comparing Haplo-SCT and UCBT. Therefore, it is necessary to synthesize the existing evidence regarding outcomes of stem cell transplantations comparing Haplo-SCT with UCBT. We searched article titles that compared transplantation with Haplo-SCT and UCBT in MEDLINE (PubMed), Cochrane library, and EMBASE database. To compare clinical outcomes between Haplo-SCT and UCBT, we performed a meta-analysis of 12 studies and reported the pooled odds ratios (ORs) of 6 end points including overall survival (OS), progression-free survival (PFS), nonrelapse mortality (NRM), relapse rate (RR), acute graft-versus-host disease (aGVHD), and chronic graft-versus-host disease (cGVHD). We found that Haplo-SCT was associated with a significantly superior OS (pooled OR of 0.74, 95% confidence interval [CI] 0.68 to 0.80) and PFS (0.77, 95% CI 0.72 to 0.83), as well as a lower NRM (0.72, 95% CI 0.64 to 0.80) and aGVHD (0.87, 95% CI 0.77 to 0.98) compared to the UCBT group. We also found a significantly increased risk of cGVHD in Haplo-SCT group (1.40, 95% CI 1.22 to 1.62). In terms of RR, Haplo-SCT was comparable to UCBT (0.91, 95% CI 0.79 to 1.05). Results of this meta-analysis demonstrate that Haplo-SCT results in better clinical outcomes compared to UCBT in terms of OS, PFS, TRM, and aGVHD, but is inferior to UCBT in terms of increased cGVHD risk. Further prospective comparisons between Haplo-SCT and UCBT are needed.
Fans of Violent Music: The Role of Passion in Positive and Negative Emotional Experience
Authors: Olsen Kirk N. , Powell Merrick , Anic Aydin , Vallerand Robert J. , Thompson William Forde
Published: October 2020

Extreme metal and rap music with violent themes are sometimes blamed for eliciting antisocial behaviours, but growing evidence suggests that music with violent themes can have positive emotional, cognitive, and social consequences for fans. We addressed this apparent paradox by comparing how fans of violent and non-violent music respond emotionally to music. We also characterised the psychosocial functions of music for fans of violent and non-violent music, and their passion for music. Fans of violent extreme metal ( n=46), violent rap ( n=49), and non-violent classical music ( n=50) responded to questionnaires evaluating the cognitive (self-reflection, self-regulation) and social (social bonding) functions of their preferred music and the nature of their passion for it. They then listened to four one-minute excerpts of music and rated ten emotional descriptors for each excerpt. The top five emotions reported by the three groups of fans were positive, with empowerment and joy the emotions rated highest. However, compared with classical music fans, fans of violent music assigned significantly lower ratings to positive emotions and higher ratings to negative emotions. Fans of violent music also utilised their preferred music for positive psychosocial functions to a similar or sometimes greater extent than classical fans. Harmonious passion for music predicted positive emotional outcomes for all three groups of fans, whereas obsessive passion predicted negative emotional outcomes. Those high in harmonious passion also tended to use music for cognitive and social functions. We propose that fans of violent music use their preferred music to induce an equal balance of positive and negative emotions.
Strengths, Pitfalls, and Potential in Norway’s Approach to Special Education
Authors: Gøranson Ingrid E. , Ochoa Theresa A. , Zoeller Katherine A.
Published: October 2020

Despite not having specific special education laws, Norway’s Lov om grunnskolen og den vidaregåande opplæringa (Act Relating to Primary and Secondary Education and Training) law provides individualized instruction to students who qualify for special education services after an extensive evaluation process. Improvements are recommended in special education competency among general education teachers to improve the educational outcomes of students with behavioral challenges and also to help educators meet Norway’s preference to keep students with disabilities in general education classrooms.
Do Violations of Global Beliefs and Goals Drive Distress and Meaning Making Following Life Stressors?
Authors: George Login S. , Park Crystal L.
Published: October 2020

Theoretical and treatment approaches posit that violations of beliefs and goals by stressful experiences drive distress and meaning making. However, empirical work examining this notion is limited. Accordingly, we tested violations’ role in driving distress and meaning-making using repeated assessments among 180 undergraduates coping with a recent significant stressor. On four occasions over two months, we collected data on belief and goal violations, distress, and meaning making. A within-person analytic approach showed that when participants' violations changed, their distress and meaning making also changed in the same direction. Additionally, violations had a unique association with meaning making, independent of distress. Results suggest that experiencing discrepancy between a stressor and one's beliefs and goals may be distressing and lead to efforts to reduce that discrepancy. Additional research on how individuals successfully resolve violations could improve understanding and treatment of individuals dealing with significant stressors.
Ankyloglossia Superior Syndrome With Complex Craniofacial Anomalies: Case Report and Literature Review
Authors: Hara Takayuki , Tanaka Susumu , Kogo Mikihiko
Published: October 2020

Ankyloglossia superior syndrome is an extremely rare entity in which centrally located glossopalatine ankylosis is a principal feature. Some cases are accompanied by cleft palate, micrognathia, or tongue hypoplasia, and affected patients need careful nutritional and respiratory support. We describe a newborn girl in whom ankyloglossia superior syndrome comprised complex craniofacial malformations, including cleft palate, micrognathia, microglossia, and natal teeth as well as limb anomalies. Surgical treatment entailed release of synechiae, and glossopexy was performed successfully to prevent postsurgical airway complications and to ensure adequate nutrition by nipple feeding during infancy.
Acceptability of pharmacist-led interventions to resolve drug-related problems in patients with chronic myeloid leukaemia
Authors: Tan Bee Kim , Chua Siew Siang , Chen Li-Chia , Chang Kian Meng , Balashanker Sharmini , Bee Ping Chong
Published: October 2020

Purpose

Chronic myeloid leukaemia (CML) patients on long-term tyrosine kinase inhibitor (TKI) therapy are susceptible to drug-related problems (DRPs). This study aimed to evaluate the acceptability and outcomes of pharmacist-led interventions on DRPs encountered by CML patients.

Methods

This study included participants from the intervention arm of a randomised controlled trial which was conducted to evaluate the effects of pharmacist-led interventions on CML patients treated with TKIs. Participants were recruited and followed up in the haematology clinics of two hospitals in Malaysia from March 2017 to January 2019. A pharmacist identified DRPs and helped to resolve them. Patients were followed-up for six months, and their DRPs were assessed based on the Pharmaceutical Care Network Europe Classification for DRP v7.0. The identified DRPs, the pharmacist’s interventions, and the acceptance and outcomes of the interventions were recorded. A Poisson multivariable regression model was used to analyse factors associated with the number of identified DRPs per participant.

Results

A total of 198 DRPs were identified from 65 CML patients. The median number of DRPs per participants was 3 (interquartile range: 2, 4). Most participants (97%) had at least one DRP, which included adverse drug events (45.5%), treatment ineffectiveness (31.5%) and patients’ treatment concerns or dissatisfaction (23%). The 228 causes of DRPs identified comprised the following: lack of disease or treatment information, or outcome monitoring (47.8%), inappropriate drug use processes (23.2%), inappropriate patient behaviour (19.9%), suboptimal drug selection (6.1%), suboptimal dose selection (2.6%) and logistic issues in dispensing (0.4%). The number of concomitant medications was significantly associated with the number of DRPs (adjusted Odds Ratio: 1.100; 95% CI: 1.005, 1.205; p = 0.040). Overall, 233 interventions were made. These included providing patient education on disease states or TKI-related side effects (75.1%) and recommending appropriate instructions for taking medications (7.7%). Of the 233 interventions, 94.4% were accepted and 83.7% were implemented by the prescriber or patient. A total of 154 DRPs (77.3%) were resolved.

Conclusions

The pharmacist-led interventions among CML patients managed to identify various DRPs, were well accepted by both TKI prescribers and patients, and had a high success rate of resolving the DRPs.
Clinical outcomes of open hip abductor tendon repair with minimum two-year follow-up
Authors: Balazs George C , Dooley Matt , Wang Dean , O’Sullivan Eilish , Kelly Bryan T
Published: October 2020

Background:

The results of open hip abductor tendon repair remains poorly defined. We sought to present the results and complications of this procedure using modern suture anchor fixation.

Materials and Methods:

Our prospective institutional hip preservation registry was queried for all patients who underwent open hip abductor tendon repair with minimum 2-year follow-up were identified. Demographic, clinical, intraoperative, and functional outcome details were recorded. Patient-reported outcome scores (PROs) including the modified Harris Hip Score (mHHS), HOS-ADL, HOS-S, and iHOT-33 were collected for the preoperative and final postoperative state. Risk factors for lower final mHHS and change in mHHS were analysed using a multiple regression model.

Results:

A total of 21 patients with mean 48 months clinical follow-up (range 24–84 months). Median mHHS improved from 49.50 preoperatively to 82.50 postoperatively ( p < 0.001), median HOS-ADL improved from 60.29 to 82.35 ( p = 0.001), median HOS-S improved from 37.50 to 60.00 ( p = 0.04), and median iHOT-33 improved from 29.81 to 70.15 ( p = 0.001). All patients had +4 or +5 hip abductor strength at final in-person examination at mean 17 months postoperatively. All patients with a preoperative Trendelenburg gait had complete resolution at final examination. There 2 complications, and no patient had re-tear or revision surgery. LCEA < 25° and a history of prior ipsilateral hip surgery were independently predictive of smaller improvement in mHHS at final follow-up.

Conclusions:

Open abductor tendon repair is a safe and effective procedure that provides sustained symptomatic and functional improvements at mid-term follow-up.
Identification of Hub Genes and Potential Molecular Mechanisms in Patients with HBV-Associated Acute Liver Failure
Authors: Sun Ying , Yu Haitao , Li Fangfang , Lan Liqiang , He Daxin , Zhao Haijun , Qi Dachuan
Published: October 2020

Hepatitis B virus (HBV) infection is a major cause of acute liver failure (ALF) in China, and mortality rates are high among patients who do not receive a matched liver transplant. This study aimed to determine potential mechanisms involved in HBV-ALF pathogenesis. Gene expression profiles under access numbers GSE38941 and GSE14668 were downloaded from the Gene Expression Omnibus database, including cohorts of HBV-ALF liver tissue and normal samples. Differentially expressed genes (DEGs) with false discovery rates (FDR) <0.05 and |log2(fold change)| >1 as thresholds were screened using the Limma package. Gene modules associated with stable disease were mined using weighed gene co-expression network analysis (WGCNA). A co-expression network was constructed and DEGs were analyzed using gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A gene-based network was constructed to explore major factors associated with disease progression. We identified 2238 overlapping DEGs as crucial gene cohorts in ALF development. Based on a WGCNA algorithm, 10 modules (modules 1-10) were obtained that ranged from 75 to 1078 genes per module. Cyclin-dependent kinase 1 ( CDK1), cyclin B1 ( CCNB1), and cell-division cycle protein 20 ( CDC20) hub genes were screened using the co-expression network. Furthermore, 17 GO terms and 6 KEGG pathways were identified, such as cell division, immune response process, and antigen processing and presentation. Two overlapping signaling pathways that are crucial factors in HBV-ALF were screened using the Comprehensive Toxicogenomics Database (CTD). Several candidate genes including HLA-E, B2M, HLA-DPA1, and SYK were associated with HBV-ALF progression. Natural killer cell-mediated cytotoxicity and antigen presentation contributed to the progression of HBV-ALF. The HLA-E, B2M, HLA-DPA1, and SYK genes play critical roles in the pathogenesis and development of HBV-ALF.