bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Efficacy of the Huo Xue Hua Yu Method Combined with Aspirin in the
Treatment of Acute Cerebral Infarction: A Systematic Evaluation and Meta-analysis
Authors: Chen Chu , Ma Fang , Wen Xinli , Liu Xing , Tang Qing , Wu Yilun
Published: June 2023

Objective:

The study aimed to evaluate the clinical efficacy of the Huo Xue Hua Yu method combined
with aspirin in the treatment of patients with acute cerebral infarction (ACI).

Methods:

By searching electronic databases, such as the Chinese Biomedical Literature Database (CBM), the
China National Knowledge Infrastructure Database (CNKI), the China Science and Technology Journal Database,
Wanfang, PubMed, Embase, and the Cochrane Library, all randomized controlled trials (RCTs) published
before 14 July, 2022, and published in Chinese or English languages were selected. Statistical analysis was performed
using Review Manager 5.4 calculation software to calculate the odds ratio (OR), mean difference (MD),
95% confidence interval (CI), and p values.

Results:

13 articles that included 1,243 patients were identified; in 646 of them, the Huo Xue Hua Yu method
combined with aspirin has been administered, while 597 have only been administered aspirin therapy. The
combined treatment significantly improved clinical efficacy (OR: 4.41, 95% CI: 2.90 to 5.84, p < 0.001, I2 = 0),
as assessed by the National Institutes of Health Stroke Scale score (MD = -4.18, 95% CI: -5.69 to -2.67, p <
0.001, I2 = 94%), Barthel score (MD = -2.23, 95% CI: -2.66 to -1.81, p < 0.001, I2 = 82%), the China Stroke
Scale score (MD = 6.74, 95% CI: -3.49 to 16.96, P = 0.20, I2 = 99%), packed cell volume (MD = -8.45, 95%
CI: -8.81 to -8.09, p < 0.001, I2 = 98%), fibrinogen levels (MD = -0.93, 95% CI: -1.23 to -0.63, p < 0.001, I2 =
78%) and plasma viscosity (MD = -0.51, 95% CI: -0.72 to -0.30, p < 0.001, I2 = 62%).

Conclusion:

The combination of the Huo Xue Hua Yu method and aspirin represents a beneficial adjunctive
therapy for ACI.
Peganum harmala L.: A Review of Botany, Traditional Use, Phytochemistry, Pharmacology, Quality Marker, and Toxicity
Authors: Li Ling-Na
Published: June 2023

Background:

Peganum harmala L. is a perennial herb of Peganum in Zygophyllaceae family. It has been used as a national medicinal herb with the efficacy of strengthening muscle, warming stomach, dispelling cold, and removing dampness in Chinese folk. Clinically, it is mainly used to treat diseases such as weak muscles and veins, joint pain, cough and phlegm, dizziness, headache, and irregular menstruation.

Methods:

The relevant information about P. harmala L. in this review is based on online databases, including Elsevier, Willy, Web of Science, PubMed, ScienceDirect, SciFinder, SpringLink, Google Scholar, Baidu Scholar, ACS publications, SciHub, Scopus, and CNKI. The other information was acquired from ancient books and classical works about P. harmala L.

Results:

P. harmala L. is an important medicinal plant with a variety of traditional uses according to the theory of Chinese medicine. Phytochemical research revealed that P. harmala L. contained alkaloids, volatile oils, flavonoids, triterpenoids, coumarins, lignins, anthraquinones. Modern studies showed P. harmala L. possessed multiple bioactivities, including anti-cancer, neuroprotective, anti-bacterial, anti-inflammatory, hypoglycemic, anti-hypertensive, anti-asthmatic, and insecticidal activities. Furthermore, the contents of the quality marker and toxicity of P. harmala L. were summarized and analyzed in this review.

Conclusion:

The botany, traditional use, phytochemistry, pharmacology, quality marker, and toxicity of P. harmala L. were reviewed in this paper. It will not only provide an important clue for further studying P. harmala L., but also supply an important theoretical basis and valuable reference for in-depth research and exploitations of this plant in the future.
Oncogenic Alterations of Metabolism Associated with Resistance
to Chemotherapy
Authors: Ghasemi Fahimeh , Farkhondeh Tahereh , Samarghandian Saeed , Ghasempour Alireza , Shakibaie Mehdi
Published: June 2023

Metabolic reprogramming in cancer cells is a strategy to meet high
proliferation rates, invasion, and metastasis. Also, several researchers indicated that the
cellular metabolism changed during the resistance to chemotherapy. Since glycolytic
enzymes play a prominent role in these alterations, the ability to reduce resistance to
chemotherapy drugs is promising for cancer patients. Oscillating gene expression of
these enzymes was involved in the proliferation, invasion, and metastasis of cancer
cells. This review discussed the roles of some glycolytic enzymes associated with
cancer progression and resistance to chemotherapy in the various cancer types.
Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of
Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt Hypertensive
Rats
Authors: Cassinotti Luis , Guil María , Bianciotti Liliana , Vatta Marcelo
Published: June 2023

Background:

We previously reported that endothelins (ETs) regulate tyrosine hydroxylase
(TH) activity and expression in the olfactory bulb (OB) of normotensive and hypertensive animals.
Applying an ET receptor type A (ETA) antagonist to the brain suggested that endogenous ETs bind to
ET receptor type B (ETB) to elicit effects.

Objective:

The aim of the present work was to evaluate the role of central ETB stimulation on the regulation
of blood pressure (BP) and the catecholaminergic system in the OB of deoxycorticosterone acetate
(DOCA)-salt hypertensive rats.

Methods:

DOCA-salt hypertensive rats were infused for 7 days with cerebrospinal fluid or IRL-1620
(ETB receptor agonist) through a cannula placed in the lateral brain ventricle. Systolic BP (SBP) and
heart rate were recorded by plethysmography. The expression of TH and its phosphorylated forms in the
OB were determined by immunoblotting, TH activity by a radioenzymatic assay, and TH mRNA by
quantitative real-time polymerase chain reaction.

Results:

Chronic administration of IRL-1620 decreased SBP in hypertensive rats but not in
normotensive animals. Furthermore, the blockade of ETB receptors also decreased TH-mRNA in
DOCA-salt rats, but it did not modify TH activity or protein expression.

Conclusion:

These findings suggest that brain ETs through the activation of ETB receptors contribute to
SBP regulation in DOCA-salt hypertension. However, the catecholaminergic system in the OB does not
appear to be conclusively involved although mRNA TH was reduced. Present and previous findings
suggest that in this salt-sensitive animal model of hypertension, the OB contributes to chronic BP
elevation.
Predicting the Adsorption Behavior of 6-mercaptopurine Anticancer Drug
upon Polyoxazoline Nanocarrier: A Theoretical Study
Authors: Rahmanifar Leila , Azarakhshi Fatemeh , Moniri Elham
Published: June 2023

Predicting the adsorption behavior of the 6-Mercaptopurine (MCP) anticancer drug upon
the polyoxazolinenano-carrier was investigated using DFT and TD-DFT methods by B3LYP/6-31G*
level in the gas phase and water solution. Based on the thermochemical parameters, the MCP/polymer
complex in the solvent water is more stable rather than the gas phase. The adsorption energies of the
MCP/polymer complex displayed that the adsorption process is exothermic. The UV/Vis absorption
and IR spectra analysis were calculated to investigate the changes happening in the interaction of the
MCP with the polymer. FMO analysis indicated that the energy gap (Eg) of the polymer decreased after
the adsorption process. Electronic properties and MEP analysis were also studied. Based on NBO
analysis and charge difference (ΔN), the charge transfer in MCP/polymer occurs essentially from the
polymer to the MCP drug, which is consistent with the results of NBO analysis. It is predicted that the
POZ polymer can be used as a drug delivery system for MCP drug.
Nanotechnology-Based Approaches for Nose-to-Brain Drug Delivery in Neurodegenerative Diseases
Authors: Shukla Sugat , Tiwari Srishti , Bhattacharya Ragghee , Ojha Smriti , Mishra Sudhanshu , Gupta Saurabh Kumar
Published: June 2023

:

Drug delivery to the brain is a challenging task as many drugs do not cross the blood-brain
barrier (BBB). As a result, designing strategies to target drugs to the brain requires significant effort.
However, recent research has focused on the administration of drugs through the nose to the brain, a noninvasive
way to bypass the BBB and deliver therapeutic molecules directly to the brain. Nose-to-brain
drug delivery is a promising approach that allows for the direct transportation of therapeutic molecules to
the brain while increasing drug concentration in the brain. This approach has gained considerable attention
due to its non-invasive nature, which makes it feasible, reliable, and efficient. One promising approach
for nose-to-brain drug delivery is the use of nanoparticles as a platform for drug and gene delivery.
Nanoparticles offer several advantages, including the ability to protect therapeutic drugs from degradation
and increase the efficacy of drug delivery due to their unique size, shape, and surface features. Nanoparticles
can also be engineered to target specific cells or tissues, enabling more precise drug delivery to the
brain. The use of nanoparticles for nose-to-brain drug delivery has been extensively studied, and recent
developments have shown promising results. In addition, patents relating to medication targeting via the
nasal route have been developed. These patents cover various aspects of drug delivery, including the use
of different types of nanoparticles, methods for producing nanoparticles, and methods for delivering nanoparticles
to the brain.
Synthesis and Evaluation of Novel Substituted N-Aryl 1,4-Dihydropyridines as Antituberculostatic Agents
Authors: Seitz Lisa , Reiling Norbert , Vorreiter Christopher , Sippl Wolfgang , Kessler Sonja , Hilgeroth Andreas
Published: June 2023

Background:

Tuberculosis has been the main cause of mortality of infectious diseases
worldwide, with strongly limited therapeutic options. With increasing resistance and missing suitable
drugs in those cases, there is a strong need for novel antituberculostatic drugs. We developed novel
N-aryl 1,4-dihydropyridines with various substitution patterns to evaluate them as antituberculostatic
agents.

Methods:

1,4-Dihydropyridine derivatives were synthesized and purified by column chromatography
or recrystallization. The mycobacterial growth inhibition was determined in a fluorescent mycobacterial
growth assay.

Results:

The compounds were prepared in a simple one-pot reaction under acidic conditions with
structurally varied components. The substituent effects on the determined mycobacterial growth inhibitory
properties are discussed.

Conclusion:

Lipophilic diester substituted derivatives show promising activities that were additionally
affected by the aromatic substituent functions. Thus, we identified compounds with activities almost
reaching that of the used antimycobacterial drug as control.
Entropy Measures with Three-axis Motion Time-series Data: Comparison of Dominant and Non-dominant Hand in Multi-directional Reach
Authors: Praditpod Nuttaporn , Tantipoon Phongpan , Zhang Xinyu , Rauchhaus Petra , Li Chunhui , Huang Zhihong
Published: June 2023

Background:

Motion variance differs among individuals, knowing as the differences in dominant and non-dominant hand functions provide beneficial information to clinicians or therapists regarding accurate diagnosis and rehabilitation purposes. However, due to subjective considerations, there are some limitations of the handedness questionnaires, which are one of the standard methods for evaluating interlimb function differences.

Objective:

This study aims to quantify the differences in upper limb motions between the dominant and non-dominant hands in the reaching task using approximate entropy (ApEn) and sample entropy (SampEn) measures. This study also provides proper combinations of parameter valuesmandrfor the ApEn and SampEn measures in the hand movement data of the reaching task.

Methods:

Twenty volunteers performed a multi-directional reaching task. The acceleration data of hand motions were recorded by GENEActiv 3D acceleration sensor (Activinsights Ltd., UK) with a sampling frequency of 1000 Hz. In addition, the ApEn and SampEn values were analysed.

Results:

The ApEn values of the dominant hand were statistically significantly lower than those of the non-dominant hand for parameter combinations ofm=2,3,4,5 withr=0.15,0.20,0.25 for the Y- and Z-axis (p<0.05). The SampEn values of the dominant hand significantly demonstrated lower than those of the non-dominant hand for all axes when computing on combinations of parameterm=2,3,4,5 withr=0.15,0.20 (p<0.05).

Conclusion:

The ApEn and SampEn measures could be used to predict the degree of regularity or complexity of the reaching hand motion time-series data. These entropy measures also reveal the differences between the dominant and non-dominant hand movements, quantifying movement differences in the dynamic motor tasks associated with hemispheric brain asymmetry.
Strengthening Communication: A Strategy to Increase Community Satisfaction in Stunting Services in Indonesia
Authors: Sazali Hasan , Utami Tri Niswati , Batubara Chuzaimah , Azizah Noor , Susilawati Susilawati , Padli Nasution Muhammad Irwan , Albani Nasution Muhammad Syukri , Sari Seva Maya , Harahap Rafnitul Hasanah
Published: June 2023

Introduction:

The Indonesian government has prioritized stunting management programs, but until 2022 the prevalence of stunting is still high.

Objectives:

The purpose of this research is to develop a strategy to increase community satisfaction with stunting services oriented toward strengthening communication.

Methods:

This is a cross-sectional design research with data collected from a sample population of 298 mothers who have stunted children through a survey and analyzed using path analysis with SEM-PLS.

Results:

The result showed that communication affects stunting service facilities and sanitation management with a P-value of 0.000, respectively. Communication does not directly affect stunting service satisfaction, it is moderated by the variables of facilities and sanitation, which play a role in strengthening or weakening the effect of stunting service satisfaction. An essential factor that can be used to produce optimal stunting service satisfaction is strengthening communication.

Conclusion:

Strengthening communication between regional institutions at the Regency level synergistically supports the provision of the required facilities, thereby increasing community satisfaction. Furthermore, strengthening cross-sectoral communication synergistically in managing environmental sanitation supports stunting service programs. This research contributes to the government's emphasis on stunting service policies to strengthen communication between service providers and cross-sectoral communication.
Studies on Secondary Metabolites and In vitro and In silico Anticholinesterases
Activities of the Sea Urchin Echinometra mathaei Crude Venoms
from the Persian Gulf-Bushehr
Authors: Dehghani Hamideh , Rashedinia Marzieh , Mohebbi Gholamhossein , Vazirizadeh Amir
Published: June 2023

Background:

Echinoderms are a unique source of amazing secondary metabolites with a wide
spectrum of biological activities. Several species of sea urchins contain various toxins and biologically
active metabolites. One of the most attractive approaches to treat Alzheimer's disease is searching for
effective marine natural products with cholinesterase inhibitory activities.

Objective:

The current study is designed to investigate the in vitro and in silico acetylcholinesterase and
butyrylcholinesterase inhibitory activities of the Persian Gulf echinoderm sea urchin Echinometra
mathaei venom and related chemical compounds.

Methods:

The experiments for LD50, total protein, protein bands, in vitro cholinesterase inhibitory activities,
the identity of secondary metabolites, and the in silico evaluations, respectively, were performed by
Spearman-Karber, Lowry, SDS-PAGE, Ellman's spectroscopic, GC-MS, and docking methods.

Results:

The LD50 (IV rat) of the spine, gonad, and coelomic fluid from sea urchin samples were 2.231 ±
0.09, 1.03 ± 0.05, and 1.12 ± 0.13 mg/ml, respectively. The SDS-PAGE and total protein studies showed
that at least a portion of the venom is protein in nature. GC-MS analysis of the identified samples revealed
12, 23, and 21 compounds with different chemical types, including alkaloids, terpenes, and steroids,
respectively. According to the results, all samples act as significant inhibitors of both enzymes. In
silico data for the identified compounds also confirmed the experimental results.

Conclusion:

The alkaloid compound 6H-Indolo[3,2,1-de] [1,5] naphthyridine-6-one,1,2,3a,4,5-
hexahydro-8-hydroxy-3-methyl (C7) had the highest affinity for both enzymes. Further research is needed
to determine whether C7 could be a therapeutic candidate for Alzheimer's disease.
Energy Saving Optimal Operation Strategy of Freight Trains under
Complex Scenarios
Authors: Yi Lingzhi , Xie Cheng , Wang Yahui , Liu Jiangyong , Yi Chuyang , Jiang Wenbo
Published: June 2023

Background:

For the optimization of energy-saving driving of freight trains in complex operating
environments, the use of reasonable train maneuvering methods can largely reduce the energy
consumption of train traction. Recent patents on energy-efficient maneuvering strategies for complex
scenarios of freight trains have been researched.

Objective:

Using the receding horizon algorithm and the improved NSGA-II algorithm to solve the target
speed curve of freight trains to cope with the complex and changing operating environment, and to
explore the recent patents of energy-saving maneuvering strategies for freight trains and methods.

Methods:

The recent patents of energy-efficient maneuvering strategies for freight trains in complex
scenarios are investigated in this research. A multi-objective optimization model for freight train maneuvering
with electrical phasing was developed with the objectives of reducing the traction energy
consumption and running time of the train. A method for determining the optimal operating conditions
of freight trains under complex line conditions is proposed. The offline optimization of the target speed
curve under the electrical phasing constraints of freight trains and the online adjustment under the temporary
speed restriction (TSR) are achieved by using the RH-INSGA-II (receding horizon-improved
NSGA- II) algorithm.

Results:

Combined with an actual freight railroad line data as an example, simulation experiments were
conducted and verified with HXD1 electric locomotive hauling 50 C80 wagons.

Conclusion:

The speed curve considering the split-phase constraint can effectively reduce the traction
energy consumption. The electrical split-phase constraint affects the whole speed optimization process,
not only the speed curve at the split-phase zone. Although the traction energy consumption is increased
with the addition of the TSR on the line, the RH-INSGA-II algorithm dynamically changes the sequence
of optimal train maneuvering conditions according to the planned train running time in order to avoid
further amplification of the late train time.
Synthetic Biology and Tissue Engineering
Authors: Mutlu Betül , Arı-Yuka Selcen , Aslan Ayça , Çakır-Koç Rabia
Published: June 2023

Advanced approaches that can mimic the structure and function of natural
tissue in tissue engineering applications that use multidisciplinary engineering
approaches to repair damaged or dysfunctional tissues are fed forward by current
engineering applications. Manipulating cells or cell groups in an integrated manner into
the scaffold, similar to the native tissue composition, is the main challenge in these
approaches. Synthetic biology approaches, originating from genetic engineering, based
on the use of advanced tools in the manipulation of cells at the molecular level, are one
of the most current issues in tissue engineering that shed light on the programming of
cells. Synthetic biology tools allow the reprogramming of cells whose transcriptional,
translational, or post-translational molecular mechanisms have been engineered by
stimulating them with intrinsic or extrinsic signals. Combining these advanced and
excellent tools from synthetic biology with materials engineering applications of tissue
engineering is the latest fashion. This chapter discusses going beyond conventional
tissue engineering applications, synthetic biological molecular tools, circuit designs
that allow the complex behavior of cells to be manipulated with these tools, and
approaches that enable the integration of these tools into the material component of
tissue engineering
Voorwoord
Authors: Hardyns Wim
Published: June 2023

Voorwoord
Inhoudstafel/Table des matières
Authors: Outreach OCAD/OCAM
Published: June 2023

Inhoudstafel/Table des matières
Gouvernementalité de la guerre d’invasion russe en Ukraine : de la définition de l’état de guerre permanent comme nouvelle « raison d’Etat » en Russie
Authors: Gosset Nicolas
Published: June 2023

En lien indissociable de laquestion géopolitique et du rapport à « l’Ouest collectif » euro-atlantique, laguerre d’invasion de l’Ukraine par la Russie a une dimension manifeste d’exacerbationde la gouvernementalité poutinienne, dans laquelle se précise la redéfinitionen cours de l’état de guerre – permanent ? – comme nouvelle « raison d’État »en Russie. Pendant vingt ans, le pouvoir du gouvernement de Vladimir Poutine atenu grâce à la démobilisation de la population russe, incitée à nes’intéresser ni aux guerres ni à la chose publique en général. Mais le régimeopère aujourd’hui un basculement total, en demandant à la société de se levercomme un seul homme et de consentir à de grands sacrifices. À n’en pointdouter, le poutinisme est aujourd’hui à un point de bascule et demandera deplus en plus à sa population. Une forme de « restalinisation partielle » desrapports entre l’État et la société est en marche en Russie. Les effets en sontaussi larges que profonds.
Electroplating Jig Design for Mild Steel Nut for Cobalt Alloy Plating
Authors: Ahmad Nawawi Natasha , Anyryza Azizee Amirul , Hyie Koay Mei
Published: June 2023

This partly ongoing research focuses on designing a stainless-steel jig holder for varied sizes of mild steel nuts for cobalt alloy plating, scaled to industry-level requirements for field testing. The chosen type of electroplating jig is rack plating. The modelling and analysis of the design were done using SolidWorks software, which included 3D design and finite element analysis. The result shows the strength of the jig holder is reliable for nut sizes ranging from M8 to M16. In conclusion, the jig holder performance has been successfully optimized based on the material and design chosen for its simulation.
Elements, Specifications and Functions of Technical Design of Special Effects in the Musical Theatre Performances
Authors: Hashim Hafshizan , Zulkepeli Mohd Kamil , Abd Rahman Khairul Aidil Azlin
Published: June 2023

Musical theatre performance is a complex work in contrast to the other theatre medium that requires a more dominant combination of acting, singing, music, and choreography. Similarly, the support of the technical special effects design should also be given more attention, especially during its production. This paper reviews the elements of technical special effects on the selected case studies to specify their design needs and purposes. The outcome indicates the effectiveness of the overall musical theatre performance, which features customization specifications and functions in producing technical design of special effects.
Shape Grammar and Formal Aesthetic Functions Spatial Relationship for Car Chassis Design
Authors: Mohd Yusof Wan Zaiyana , Zainul Azman Amirul Syafiq , Isa Siti Salwa , Ali Abu
Published: June 2023

The developing of computer tools accelerate the designs phase for designers but the aesthetics of product appearance cannot be neglected. Shape grammar is a general computational language that manipulates shapes to generate designs. By defining the spatial relationships between those forms and how the forms are related to each other, shape rules can be written. Shape grammar was used as a tool for observing spatial relationships of design elements and principles of a space frame chassis and using biomimicry theory to give inspiration and ideas to create the new concept of supercars chassis design.
Factors Influencing Clinicians’ Use of Hospital Information Systems for Infection Prevention and Control: Cross-Sectional Study Based on the Extended DeLone and McLean Model (Preprint)
Authors: Zheng Feiyang , Wang Kang , Wang Qianning , Yu Tiantian , Wang Lu , Zhang Xinping , Wu Xiang , Zhou Qian , Tan Li
Published: June 2023

BACKGROUND

Healthcare-associated infections have become a serious public health problem. Various types of information systems have begun to be applied in hospital infection prevention and control (IPC) practice. Clinicians are the key users of these systems, but few studies have assessed the use of infection prevention and control information systems (IPCISs) from their perspective.

OBJECTIVE

This study aimed to (1) apply the extended DeLone and McLean Information Systems Success model (D&M model) that incorporates IPC culture to examine how technical factors like information quality, system quality, and service quality, as well as organizational culture factors affect clinicians’ use intention, satisfaction, and perceived net benefits, and (2) identify which factors are the most important for clinicians’ use intention.

METHODS

A total of 12,317 clinicians from secondary and tertiary hospitals were surveyed online. Data were analyzed using partial least squares-structural equation modeling and the importance-performance matrix analysis.

RESULTS

Among the technical factors, system quality (β=.089-.252; P<.001), information quality (β=.294-.102; P<.001), and service quality (β=.126-.411; P<.001) were significantly related to user satisfaction (R2=0.833), use intention (R2=0.821), and perceived net benefits (communication benefits [R2=0.676], decision-making benefits [R2=0.624], and organizational benefits [R2=0.656]). IPC culture had an effect on use intention (β=.059; P<.001), and it also indirectly affected perceived net benefits (β=.461-.474; P<.001). In the importance-performance matrix analysis, the attributes of service quality (providing user training) and information quality (readability) were present in the fourth quadrant, indicating their high importance and low performance.

CONCLUSIONS

This study provides valuable insights into IPCIS usage among clinicians from the perspectives of technology and organization culture factors. It found that technical factors (system quality, information quality, and service quality) and hospital IPC culture have an impact on the successful use of IPCISs after evaluating the application of IPCISs based on the extended D&M model. Furthermore, service quality and information quality showed higher importance and lower performance for use intention. These findings provide empirical evidence and specific practical directions for further improving the construction of IPCISs.
Selecting behaviour change techniques for asthma medication adherence apps: an evidence-based approach for developers (Preprint)
Authors: Wright Alison J , Holland Jeremy , Simpson Iain , Walker Samantha , Bennett-Steele Naomi , Weinman John
Published: June 2023

BACKGROUND

Poor medication adherence is a widespread issue that causes adverse patient outcomes and is expensive to all aspects of the healthcare system. Developing cost-effective and scalable interventions to promote medication adherence is a key goal Mobile apps hold promise as a mode of delivery for adherence interventions, but app design rarely takes into account the behavioural influences on non-adherence with sufficient rigour. As a result, apps may not realise their full potential at enhancing adherence. Medication non-adherence is common among adults prescribed preventer inhalers for asthma and has a variety of influences, creating a need to identify what components, or behaviour change techniques (BCTs), apps should include to effectively tackle each influence.

OBJECTIVE

To identify which BCTs could be included in a medication adherence app to tackle specific influences on adherence to preventer inhalers in people with asthma.

METHODS

Key influences on preventer inhaler adherence in adults with asthma were identified based on reviews of peer reviewed and less formal literature, and domain expert knowledge. These influences were then mapped to a published set of 26 mechanisms of action of behaviour change interventions. Next, candidate BCTs to change each mechanism of action (MoA) were identified using the Theory & Techniques Tool (TaT Tool), an online resource that reflects almost 100 expert behavioural scientists’ consensus about which BCTs are most likely to change particular MoAs. Finally, candidate BCTs were filtered by considering their potential acceptability and practicability.

RESULTS

32 influences on preventer inhaler adherence were identified and coded to 14/26 of the influences on behaviour listed by the TaT Tool. The initial mapping of influences on behaviour to candidate BCTs to change those influences identified 42 candidate BCTs. After applying the acceptability and practicality elements of the APEASE criteria to the BCTs, the number of BCTs suggested for inclusion reduced to 24.

CONCLUSIONS

Using an evidence-based approach, this study identified 24 BCTs that may be particularly useful to include in apps promoting adherence to preventer inhalers in order to target particular influences on adherence. The list can be used by app developers to improve the quality of adherence behaviour change support, which their apps provide, or by healthcare decision-makers to identify which apps contain elements addressing a range of adherence difficulties.
Streamlining data collection and management of mHealth, Wearable, and IoT in Digital Behavioral Health Intervention with ADAM: A Novel Informatics Architecture (Preprint)
Authors: Pulantara I Wayan , Wang Yuhan , Burke Lora E. , Sereika Susan M. , Bizhanova Zhadyra , Kariuki Jacob K. , Beatrice Britney , Loar India , Cedillo Maribel , Conroy Molly B. , Parmanto Bambang
Published: June 2023

UNSTRUCTURED

The Awesome Data Acquisition Method (ADAM) is a versatile web-based system that is designed for integrating data from different sources and managing a large-scale multi-phase research study. As a data collecting system, ADAM allows the collection of real-time data from wearable devices through the device’s Application Programmable Interface (API) and mobile app adaptive real-time questionnaires. As a clinical trial management system, ADAM integrates clinical trial management processes and efficiently supports the recruitment, screening, randomization, data tracking, data reporting, and data analysis during the entire research study process. We used a weight-loss research study (SMARTER Trial) as a test case to evaluate the ADAM system. The study was a randomized controlled trial (RCT) that screened 1741 participants and enrolled 502 adults. The ADAM system was efficiently and successfully deployed to organize and manage the SMARTER Trial. Moreover, with its versatile integration capability, the ADAM system made the necessary switch to fully remote assessments/tracking performed seamlessly and promptly when the COVID-19 pandemic ceased in-person contacts. The remote-native features afforded by the ADAM system minimized the effects of the COVID-19 lockdown on the SMARTER study. Moreover, ADAM was designed to be generalizable and scalable to fit other studies with minimal editing, re-development and customization, making it suitable for various behavioral interventions and different populations.

NIH Grant #: R01HL131583 (PI: LE Burke); R01HL131583 Diversity Supplement (PI: JK Kariuki); F31HL156278 (PI: J Cheng) ClinicalTrials.gov #: NCT03367936
Đánh giá sự phát thải khí nhà kính tại thành phố Cần Thơ - Trường hợp nghiên cứu tại ba quận Ninh Kiều, Cái Răng và Bình Thủy
Authors: Nguyễn Thị Hồng Điệp , Phan Kiều Diễm , Nguyễn Kiều Diễm , Phạm Thị Bích Thảo , Hồ Ngọc Linh , Nguyễn Minh Nghĩa , Nguyễn Trọng Nguyễn
Published: June 2023

Nghiên cứu được thực hiện nhằm phân tích phát thải khí nhà kính (KNK) từ hoạt động dân sinh, khu công nghiệp (KCN) và hoạt động đốt rơm rạ sau thu hoạch tại ba quận Ninh Kiều, Bình Thủy, Cái Răng. Cacbon dioxit (CO2), metan (CH4) và nitơ oxit (NO2) là ba loại KNK chính được chọn phân tích trong nghiên cứu này, và được tính toán từ khối lượng nhiên liệu tiêu thụ trong từng hoạt động nhân với hệ số phát thải của từng nguồn tương ứng. Qua kết quả nghiên cứu, tổng lượng phát thải KNK tại khu vực nghiên cứu là 3.343.145,1 tấn CO2 tđ/năm. Trong đó, quận Bình Thủy phát thải cao nhất với 2.529.732,4 tấn CO2 tđ/năm (chiếm 75,7%), tiếp đến quận Ninh Kiều phát thải 589.178,8 tấn CO2 tđ/năm (chiếm 17,6%) và quận Cái Răng phát thải thấp nhất với 224.233,9 tấn CO2 tđ/năm (6,7%). Qua kết quả nghiên cứu, tổng quan về thực trạng phát thải KNK tại khu vực được cung cấp, từ đó, góp phần hỗ trợ công tác quản lý môi trường và đóng góp cho việc định hướng sử dụng đất trong tương lai.
Giảm thiểu mùi hôi bằng công nghệ lọc sinh học
Authors: Nguyễn Trường Thành , Phạm Văn Toàn , Kim Lavane
Published: June 2023

Nghiên cứu này được thực hiện nhằm đánh giá hiệu suất xử lý của 3 loại vật liệu đệm trong hệ thống lọc sinh học đối với việc kiểm soát các loại khí dễ gây mùi. Mùi hôi được tạo ra bằng cách phân hủy yếm khí các hợp chất hữu cơ giàu protein từ nguyên liệu cá và rác thải. Bộ lọc sinh học hấp phụ các khí có mùi vào một màng sinh học và được phân hủy sinh học bởi vi sinh vật thành các hợp chất đơn giản và ít độc hơn. Hệ thống lọc sinh học có hiệu suất loại bỏ mùi khoảng 91-98% đối với khí ammonia (NH3), từ 85% đến 95% đối với khí hydro sunfua (H2S), từ 78% đến 100% đối với khí CO và khoảng 80% đối với khí CO2. Vật liệu đệm compost với mụn xơ dừa có thời gian hấp phụ đạt trạng thái bão hòa sau 45 phút chậm hơn vật liệu đệm compost và compost với than hoạt tính, lần lượt sau 35 phút. Hệ thống lọc sinh học có khả năng xử lý phổ rộng các loại khí gây mùi và thân thiện với môi trường.
Đánh giá tình hình sử dụng và quản lý đất đai của các làng đồng bào dân tộc thiểu số huyện Krông Pa, tỉnh Gia Lai
Authors: Nguyễn Thị Lý , Đoàn Thị Quỳnh Trâm , Phạm Thị Lệ Thủy
Published: June 2023

Bài báo được thực hiện với mục tiêu góp phần hoàn thiện sử dụng và quản lý đất đai của các làng đồng bào dân tộc thiểu số (ĐBDTTS). Nghiên cứu đã sử dụng các phương pháp nghiên cứu như thu thập thông tin thứ cấp, tham vấn chuyên gia, xử lý, phân tích, tổng hợp số liệu, phương pháp so sánh, sử dụng bản đồ và phương pháp định mức. Kết quả nghiên cứu cho thấy huyện Krông Pa, tỉnh Gia Lai hiện có 81 buôn làng ĐBDTTS, đang sử dụng 43.481,28 ha đất, chiếm 26,78 % diện tích toàn huyện. Đất của 13 buôn ĐBDTTS nghiên cứu đang sử dụng 7.198,23 ha, trong đó diện tích đất nông nghiệp chiếm 84,92%. Tuy nhiên,một số vấn đề còn tồn tại như: đất chưa được đo đạc cắm mốc, đăng ký đất đai và cấp giấy chứng nhận còn nhiều, người dân còn nhiều gặp nhiều khó khăn trong công tác đăng ký đất đai, giao dịch đất đai thông qua giấy chứng nhận quyền sử dụng đất; tình hình người dân được tuyên truyền phổ biến pháp luật về đất đai còn quá thấp (18,76%). Các giải pháp nâng cao hiệu quả quản lý, sử dụng đất của các buôn làng ĐBDTTS được đề xuất gồm: Giải pháp về sử dụng đất và giải pháp về quản lý đất đai.
Xây dựng đường cong tổ hợp lượng mưa – mực nước (I-H) phục vụ thiết kế hệ thống thoát nước mặt ở thành phố Hồ Chí Minh
Authors: Lê Song Giang , Nguyễn Hoàng Thanh Bình , Nguyễn Thị Thanh Hoa , Diệp Nguyên Thịnh
Published: June 2023

Trong thiết kế hệ thống thoát nước đô thị, mực nước trong cống và độ ngập trên khu vực tiêu thoát nước phụ thuộc vào lượng mưa trên khu vực và mực nước tại cửa tiêu thoát. Đối với các đô thị nằm ở vùng trũng thấp và chịu ảnh hưởng của thủy triều như Thành phố Hồ Chí Minh (Tp.HCM), cả hai điều kiện biên, tức lượng mưa và mực nước tại cửa tiêu thoát đều là các biến ngẫu nhiên. Việc tính toán, thiết kế hệ thống thoát nước mặt và cao độ nền đòi hỏi xác định các tổ hợp lượng mưa - mực nước (I-H) ở các chu kỳ lặp lại làm điều kiện biên, thay vì chỉ xác định lượng mưa ở các chu kỳ lặp lại như trước đây. Mục tiêu của bài báo này là giới thiệu phương pháp và kết quả xây dựng các đường cong đồng chu kỳ lặp lại của tổ hợp lượng mưa - mực nước (I-H) cho các chu kỳ thiết kế và áp dụng tại Tp.HCM. Bằng cách sử dụng các đường cong này, việc tính toán và thiết kế hệ thống tiêu thoát nước mặt cũng như thiết kế cao độ nền của Tp.HCM sẽ đảm bảo tuân thủ Quy chuẩn kỹ thuật quốc gia về chu kỳ tràn cống và chu kỳ ngập.
OLS: Capacity Building in Open Science with a Peer-Led, Global, and Diverse Community
Authors: Haynes Sam
Published: June 2023

Join Sam Haynes as he introduces us to Open Life Science; a community-oriented non-profit organisation that promotes open, inclusive and equitable research. Sam discusses what capacity building in open science looks like by presenting OLS's 16-week mentoring and training program, shares the current practices OLS developed to address inequities and increase sustainability, and shares a call for more people to join the OLS community.
Aproximación a la vulnerabilidad socioterritorial de Othón P. Blanco, Quintana Roo en tiempos de COVID-19. Estudio de caso sobre turismo
Authors: Pavón-Ramírez David , Osorio García Maribel
Published: June 2023

Objetivo: analizar la vulnerabilidad socioterritorial de Othón P. Blanco, Quintana Roo en general y de Mahahual en particular, para mostrar las características que conducen a una mayor o menor capacidad de resiliencia postpandemia en un contexto turístico. Metodología: se aplicó el método de estratificación óptima con datos a la localidad urbana del municipio de Othón P. Blanco y al área geoestadística básica de Mahahual. Resultados: la vulnerabilidad se representa en una gradación que va desde muy baja hasta muy alta, y se observa que en la localidad urbana no se presentan los mismos escenarios que en el área geoestadística básica, debido a las condiciones del modelo territorial, a la estructura social y a la escala de análisis. Limitaciones: el estudio se limita a las condiciones sociodemográficas. Valor: el diseño y el cálculo de la fórmula utilizada en la investigación posibilitan la compensación cuando se estandarizan los datos para obtener un resultado equilibrado del número de indicadores establecidos para cada dimensión social. Conclusiones: existen desigualdades propias de la localización geográfica de cada territorio, por lo que los efectos del COVID-19 en los habitantes de cada espacio son heterogéneos.
Plant Disease Detection Using Convolutional Neural Networks
Authors: S Swathi
Published: June 2023

Abstract: Agriculture must complete a huge effort that involves finding plant diseases. This is something that the economy is extremely dependent on. Due to the prevalence of plant illnesses, finding infections inplants is a crucial task in the agriculture industry. It takes constant examination of the plants to spot infections in the leaves. To put it simply, monitoring the plants requires some form of planned method. The detection of damaged leaves is facilitated by program-based disease identification, which also saves time and human effort. Compared to current methods, the suggested algorithm distinguishes between plant diseases and accurately classifies them. Constant plant monitoring is labor-intensive and expensive to do by humans and it is time- consuming too
RAGAM BAHASA MAHASISWA SEMESTER 5 (LIMA) SISTEM INFORMASI STMIK PRABUMULIH
Authors: Safitri Annisa , Eka Permatasari Syelly , Dwi Yosha Ferjiela
Published: June 2023

Bahasa adalah sistem lambang yang dipahami oleh semua penutur bahasa tersebut. Bahasa daerah adalah bahasa yang dituturkan di suatu wilayah dalam sebuah negara berdaulat, yaitu di suatu daerah kecil, negara bagian federal, provinsi, atau teritorial lebih luas. Yang melatar belakangi  penelitian ini ialah adanya ragam bahasa dalam keseharian mahasiswa semester 5 (lima) Sistem Informasi STMIK Prabumulih. STMIK Prabumulih berada disalah satu kota yang ada di Sumatera bagian selatan yaitu kota Prabumulih. Penelitian ini memiliki tujuan untuk mengetahui ragam bahasa yang digunakan oleh mahasisa Sistem Informasi STMIK Prabumulih yang menggunakan tiga bahasa yaitu bahasa Palembang, bahasa Rambang, dan bahasa Belida. Dan faktor apa saja yang mempengaruhi adanya ragam bahasa mahasiswa semester 5 (lima) Sistem Informasi STMIK Prabumulih menggunakan kajian Sosiolinguistik. Penelitian ini menggunakan metode kualitatif dengan teknik deskriptif. Sumber data dalam penelitian ini yaitu ragam bahasa yang digunakan mahasiswa semester 5 (lima) sistem informasi STMIK Prabumulih yang terdiri dari tiga kelas. Teknik pengambilan data yang dipakai yaitu wawancara dan observasi langsung. Ada beberapa instrumen yang digunakan dalam penelitian ini diantaranya kamera, alat perekam, dan pedoman wawancara. Berdasarkan hasil penelitian mahasiswa semester 5 (lima) Sistem Informasi STMIK Prabumulih menggunakan salah satu ragam bahasa yaitu ragam bahasa berdasarkan daerah disebut ragam daerah (logat/dialeg).

Language is a symbol system that is understood by all speakers of that language. Regional language is the language spoken in a region within a sovereign state, namely in a small area, federal state, province, or wider territory. The background of this research is the variety of languages ​​in the daily lives of 5th semester students of the STMIK Prabumulih Information System. STMIK Prabumulih is located in one of the cities in southern Sumatra, namely the city of Prabumulih. This study aims to determine the variety of languages ​​used by Information System students of STMIK Prabumulih who use three languages, namely Palembang, Rambang, and Belida. And what factors affect the language variety of the 5th semester students of the STMIK Prabumulih Information System using sociolinguistic studies. This research uses qualitative methods with descriptive techniques. Sources of data in this study are the variety of languages ​​used by the 5th semester students of the STMIK Prabumulih information system which consists of three classes. The data collection techniques used were interviews and direct observation. There are several instruments used in this study including cameras, recording devices, and interview guides. Based on the results of research by students in semester 5 (five), the STMIK Prabumulih Information System uses a variety of languages, namely a variety of languages ​​based on regions called regional variations (dialeg).
From NEET to ‘NIITO': Defining Social Problem in Japan
Authors: Sari Rima Novita , Sunarti Herlina , Suparwati Ni Luh
Published: June 2023

This research aims to denote the phrase NEET, which became ‘niito' in Japan. NEET stands for Not in Education, Employment, or Training at its inception and refers to social problems faced by productive forces who are not in education or employment. NEET has developed into a social problem in many other countries, and the word was later renamed ‘niito' in Japan. According to the data collected, the term NEET in Japan morphed which spawned a variety of additional ‘niito' that are not only related to the workforce but also individual psychological and mental health concerns. The method of research is qualitative with descriptive analysis. The social problems theory by Richard C. Fuller dan Richard R. Myers (1941) used to find the answer; demonstrates three steps of the problems which are awareness, policy determination and reform. As results of the research, NEET in Japan originally denoted the phrase productive forces solely did not wish to work. However, as the term evolved in society, it gave rise to various ‘niito' meanings. Thus, in Japan, the term NEET refers to labor force concerns and individual psychological disorders that can contribute to a person becoming ‘niito'.
DESENVOLVIMENTO DE UMA FORMULAÇÃO COSMÉTICA ANTIOXIDANTE E FOTOPROTETORA À BASE DE CURCUMINA
Authors: Aguiar Marcelle A. , Novelli Priscilla H.G.S.
Published: June 2023

Os fotoprotetores são cosméticos com o objetivo de proteger a pele contra os efeitos deletérios da radiação solar. Mais recentemente, além de filtros solares, antioxidantes têm sido adicionados à formulação de fotoprotetores a fim de combater os radicais livres gerados pela radiação UVA. Atualmente, diversas pesquisas têm sido realizadas a fim de descobrir novos filtros solares e de origem natural. Dentre estes destaca-se a curcumina,composto polifenólico multifuncional proveniente do açafrão (Curcuma longa Linn). Neste contexto, o presente trabalho objetivou desenvolver uma formulação cosmética antioxidante e fotoprotetora à base de curcumina. Para tanto, foram preparados cinco géis. Todos continham dois filtros químicos sintéticos (octilmetoxicinamato e benzofenona-3). Além do gel padrão, contendo apenas osfiltros, foram feitas associações com curcumina, em diferentes concentrações, e com vitamina C, ambos ativos naturais. Tais formulações foram analisadas em relação à ação fotoprotetora (espectro de absorção no UV, FPS in vitro, taxa UVA/UVB e comprimento de onda crítico), poder antioxidante (DPPH), pH e características organolépticas. Em termos de ação antioxidante, a curcumina apresentou uma ação diretamente proporcional à sua concentração e quantitativamente superior à vitamina C. Já em termos de ação fotoprotetora, a curcumina conferiu às formulações uma absorção na região do UVA longo, difícil de ser contemplada por filtros químicos sintéticos. Além disso, a curcumina promoveu um aumento do FPS, da taxa UVA/UVB e do comprimento de onda crítico em relação à formulação padrão. Este efeito foi diretamente proporcional à sua concentração. Com relação ao objetivo proposto, foi possível desenvolver com sucesso um gel cosmético antioxidante e fotoprotetor contendo 0,5% de curcumina com as seguintes especificações: FPS = 11,76; Taxa UVA/UVB = 0,658; λc = 353,3 nm e IC50 = 0,34μg/mL. O uso de curcumina em fotoprotetores segue a tendência mundial do mercado cosmético de usar ingredientes naturais e desenvolver formulações multifuncionais.
The Relation Between Self-Confidence and Mathematical Problem Solving Ability on Islamic Junior High School Students
Authors: Sholihah Rifa Mar'ah , Putra Harry Dwi , Hendriana Heris
Published: June 2023

Mathematics is very important in life. The self-confidence that students have will certainly affect the process of learning mathematics. Learning objectives measure students' self-confidence towards mathematical problem-solving abilities.The aim of the study was to analyze the relationship between self-confidence and the ability to solve mathematical problems and analyze students' difficulties in solving problems on the System of Two Variable Linear Equations (SPLDV) material at Madrasah Tsanawiyah. Research using quantitative methods with correlation tests. The research sample was 20 Madrasah Tsanawiyah students. The research instrument consisted of a test to measure mathematical problem solving abilities in the form of 3 essay questions, while the non-test instrument was the self-confidence consisting of 20 statement items. . The learning method used conventionally students are divided into several groups randomly. School books are given as a guide for students in learning.The results showed that there was a very strong relationship (r = 0.83) between self-confidence and the ability to solve mathematical problems. ConclusionÂ  the results of the analysis of students' difficulties were found based on the polya step, especially at the stage of proving that students were not yet able to check the correctness of the solution in the process of working on solving mathematics. It is hoped that future research will use problem solving methods to see how self-confidence increases in the ability to solve mathematical problems.