bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of steroidal cardenolides from Calotropis procera as novel HIV-1 PR inhibitors: A molecular docking & molecular dynamics simulation study
Authors: Swapna Kandagatla , Srujana M. , Mamidala Estari
Published: October 2024

Background & objectives

Despite advancements in antiretroviral therapy, drug-resistant strains of HIV (human immunodeficiency virus) remain a global health concern. Natural compounds from medicinal plants offer a promising avenue for developing new HIV-1 PR (protease) inhibitors. This study aimed to explore the potential of compounds derived from Calotropis procera, a medicinal plant, as inhibitors of HIV-1 PR.

Methods

This in silico study utilized natural compound information and the crystal structure of HIV-1 PR. Molecular docking of 17 steroidal cardenolides from Calotropis procera against HIV-1 PR was performed using AutoDock 4.2 to identify compounds with higher antiviral potential. A dynamic simulation study was performed to provide insights into the stability, binding dynamics, and potential efficacy of the top potential antiviral compound as an HIV-1 therapeutic.

Results

We found that all tested cardenolides had higher binding affinities than Amprenavir, indicating their potential as potent HIV-1 PR inhibitors. Voruscharin and uscharidin displayed the strongest interactions, forming hydrogen bonds and hydrophobic interactions with HIV-1 PR. Voruscharin showed improved stability with lower RMSD (Root Mean Square Deviation) values and reduced fluctuations in binding site residues but increased flexibility in certain regions. The radius of gyration analysis confirmed a stable binding pose between HIV-1 PR and Voruscharin.

Interpretation & conclusions

These findings suggest that Calotropis procera could potentially be a source of compounds for developing novel HIV-1 PR inhibitors, contributing to the efforts to combat HIV. Further studies and clinical trials are needed to evaluate the safety and efficacy of these compounds as potential drug candidates for the treatment of HIV-1 infection.
α9β1 integrin & its ligands as new potential biomarkers in FMF
Authors: Ellergezen Pınar , Coşkun Belkıs Nihan , Bozkurt Zeynep Yılmaz , Çeçen Gülce Sevdar , Ağca Harun , Pehlivan Yavuz , Dalkılıç Hüseyin Ediz , Çavun Sinan , Yanar Yusuf Berkcan
Published: October 2024

Background & objectives

Familial Mediterranean Fever (FMF) manifests as a hereditary condition characterized by repeated bouts of fever, abdominal, chest, and joint discomfort, and swelling. Colchicine is the most common form of treatment, but it does not eliminate the disease. The underlying causes of the inflammatory mechanism are still not fully known.

Methods

A total of 20 healthy controls, 16 individuals with FMF in the attack period, and 14 in the remission period participated in the study. ITGA9, ITGB1, OPN, TNC, VEGF, VCAM-1, TGM2, TSP-1, Emilin-1, and vWF levels were measured by ELISA by obtaining serum from blood samples of individuals. In addition, gene expressions of α9β1 (ITGA9, ITGB1) and its best known ligands (TNC, SPP1) were analyzed by quantitative real-time PCR (qPCR).

Results

The findings of this study showed that serum levels of α9β1 and its ligands were higher in individuals with FMF in the attack period than in the healthy controls and the FMF group in the remission period (P<0.05). The marker levels of the healthy group were also higher than those in the remission period (p<0.05). In addition, when the gene expressions were compared between the healthy controls and FMF group, no significant difference was found for ITGA9, ITGB1, TNC, and SPP1 genes.

Interpretation & conclusions

The function of α9β1 and its ligands in FMF disease was investigated for the first time in this study as per our knowledge. Serum levels of these biomarkers may help identify potential new targets for FMF disease diagnosis and treatment approaches.
Surgical Treatment of Spinal Intra-Extradural Meningioma: A Clinical Case
Authors: Molotkovets Vitaliy Y. , Nekhlopochyn Oleksii S. , Marushchenko Myroslava O.
Published: October 2024

Spinal meningiomas are rare, predominantly benign tumors that exhibit slow growth and typically have a non-invasive pattern of development. They originate from arachnoid cells and fibroblasts of the dura mater. Despite their benign nature, some meningiomas can exhibit intra-extradural extension, complicating both diagnosis and treatment. This article presents a clinical case involving a patient with an intra-extradural spinal meningioma. Despite radiological imaging suggesting a neurinoma, the final diagnosis confirmed a meningioma.
Case Report: A female patient underwent surgical tumor resection through a posterolateral approach with laminectomy and facetectomy at the C4-C5 vertebral levels. The tumor, extending through the intervertebral foramen, was completely resected along with the affected nerve root. Histological examination verified a Grade II meningioma.
Discussion: Despite advancements in neuroimaging and surgical techniques, intraoperative findings can be unpredictable, necessitating an adaptive approach to tumor resection. The article emphasizes the importance of adequate preoperative planning and the use of intraoperative neurophysiological monitoring to reduce the risk of complications and improve treatment outcomes.
Conclusions: The primary treatment for spinal meningiomas is surgical. For dorsal and lateral localizations, total resection with the involved dura mater (Simpson Grade I) is optimal. For ventral localizations, tumor resection with coagulation of the dural attachment site (Simpson Grade II) is preferred. Preoperative and intraoperative use of electrophysiological methods is recommended to assess the functional status of neural structures. Intra-extradural localization of meningiomas is rare and presents significant challenges in preoperative diagnosis, requiring specific skills for effective removal.
Assessment of the Implementing The COVID-19 Health Protocol in Pandemic Situation at PT. Bank XYZ Tbk, Medan, Indonesia
Authors: Syahlan Nabila , J. EL-Matury Herlina
Published: October 2024

Background: Large-scale social Restrictions were implemented in the workplace during the COVID-19 pandemic from March 2020 to February 2022. The government has imposed restrictions on the number of workers in the workplace by implementing COVID-19 protocols at the workplace and work-from-home. This research aims to analyze the implementation of the COVID-19 protocol at PT. Bank XYZ Medan office. Methods: Observational descriptive research provides a clear picture by observing the conditions that occur directly to see how the COVID-19 protocol is implemented at PT.Bank XYZ Medan office. Quantitative methods are used. The instruments are the provision of Health Protocols from the Indonesian Minister of Health Decree No. 328 of 2020 regarding Guidelines for Preventing Control of COVID-19 in Office and Industrial Workplaces to Support Business Continuity in Pandemic Situations. Results: The implementation of the COVID-19 health protocol in the PT. Bank XYZ Medan office has a "Very Good" level of achievement. Companies can maintain the implementation of existing COVID-19 protocols during the pandemic to prevent the spread of the COVID-19 virus in the company. Conclusion: PT. Bank XYZ is expected to maintain the implementation of the COVID-19 protocol if the pandemic has not been declared over by the government of the Republic of Indonesia, and in the future improvements can be made to prevent the transmission of other diseases. Employees must continue to follow the regulations set by the company.
Fingerprint Analysis of X-Ray Absorption Spectra of Catalysts: From Linear Combination Fit to Machine-Learning Trained on Multielement Experimental Library
Authors: Protsenko Bogdan , Kakiuchi Yuya , Guda Sergey , Trummer David , Zabilska Anna , Shapovalova Svetlana , Soldatov Alexander , Safonova Olga , Coperet Christophe , Guda Alexander
Published: October 2024

X-ray absorption near edge structure (XANES) spectroscopy is a powerful method to probe the oxidation state and local structure of metals in catalytic materials. However, it suffers from the lack of unbiased data analysis protocols. Machine learning (ML) overcomes human-related factors by uncovering relevant spectrum-structure relationships and subsequent cross-validation analysis. The bottlenecks in the automatic processing of experimental data are the lack of chemically diverse XANES reference libraries and systematic differences between theory and experiment. Therefore, compiling experimental reference libraries across the periodic table and rational application of ML methodology to small (in terms of data science) training datasets becomes increasingly important. This work revises the classical XANES fingerprint analysis by database augmentation, feature extraction, cross-validation, and uncertainty analysis. We apply the developed methodology to decipher the oxidation state and local coordination of supported vanadium-oxo species (VOx), which change their structure participating in oxidative dehydrogenation catalysis. The developed library and instruments for analysis may serve as a starting point for a unified platform of fingerprint XANES data analysis.
Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties
Authors: Stopper Daniel , Biermann Lukas , Watson Paris , Li jingyu , König Beate , Gaynes Matthew , de Carvalho Lais Pessanha , Hanl Maria , Hamacher Alexandra , Schäker-Hübner Linda , Held Jana , Christianson David , Kassack Matthias , Hansen Finn Kristian
Published: October 2024

In this work, we synthesized a series of peptoid-based HDAC inhibitors with variations in the linker region and zinc-binding groups. All compounds were investigated for their HDAC inhibition, antiplasmodial activity, and cytotoxicity against native and cisplatin-resistant carcinoma cell lines. The ethylhydrazide 20 (DS-103) proved to be the most effective compound in these primary screenings. DS-103 showed nanomolar inhibition of class I HDACs and of HDAC6 (class IIb). To further investigate the binding mode of DS-103, a crystal structure of DS-103 in complex with HDAC6 was obtained, which represents the first reported crystal structure of an alkylhydrazide in complex with an HDAC enzyme. Importantly, DS-103 completely reversed cisplatin resistance in two different platinum-resistant solid cancer cell lines and demonstrated strong synergism with cisplatin. The synergistic anticancer effects are mediated by increased DNA damage and p21 expression, resulting in caspase-mediated apoptosis and cell death.
Supramolecular Self-assembly of Galactose-Based Reversed N-Nucleosides for Removal of Disperse Dyes from Aqueous Solutions
Authors: Muhammad Shoaib , Ali Firdous , Riaz Kashif , Javed Muhammad Naveed , Wasim Agha Arslan , Abid Tooba , Nabeel Muhammad , Rafique Faisal , Bari Ahmed , Saricaoglu Furkan , Hashmi Imran
Published: October 2024

This paper describes the design and synthesis of an efficient galactose-triazole based reversed N-nucleoside as a thermoreversible, low molecular weight organogelator (8a). The gelator 8a showed a phase-selective behavior toward ethyl acetate with respect to water. XRD, SEM, FTIR, and UV results showed that the xerogel has a multilamellar structure due to supramolecular forces identified as H-bonding, van der Waals interactions and stacking. The viscoelastic behavior of 8a was examined through rheology experiments, suggesting a dominant viscoelastic structure. The dye adsorption studies and desorption characteristics of 8a were explored against disperse dyes, including Foron Red RD-RBLS, Foron Blue SE-2R and Foron Black S-2B2S via UV and FTIR and SEM. The data revealed that H-bonding between dye molecules and 8a is the main force responsible for dye adsorption. Adsorption kinetics studies showed that physisorption resulted in dye adsorption. Dye removal efficiency was found to be in the range of 80%-90% in 1 h without agitation. The dyes and 8a could be recycled in excellent yields (98% and 92 %, respectively) in their pure forms.
Yielding of double-network hydrogels with systematically controlled Tetra-PEG first networks
Authors: Matsuda Takahiro , Kashimura Naohiro , Sakai Takamasa , Nakajima Tasuku , Matsushita Takuto , Gong Jian Ping
Published: October 2024

Mechanical yielding of double-network (DN) hydrogels is a distinctive feature out of the classical polymer networks, which links to the toughening of the DN gels. Previous studies have focused on the effect of swelling on yield point; however, yield strain and yield stress could not be decoupled from each other which restricted the solid understanding of the micromechanical model of the yielding. In this study, we investigated the yield point of various DN gels where the first network parameters (preparation concentration, strand arm length and network connectivity) have been systematically varied using the well-established Tetra-PEG networks. This experimental approach clarified the universal relations of (1) yield elongation ratio to the finite extensibility of the first network and (2) yield stress to the number density of the first network strands regardless of the strand length, network connectivity and orientation. This research will lead to unveiling the true physical criterion of the yielding of double-network materials.
Photocatalytic Semi-Hydrogenation of Acetylene to Polymer-Grade Ethylene with Molecular and Metal-Organic Framework Cobaloximes
Authors: Stone Aaron E.B.S. , Fortunato Anna , Wang Xijun , Saggioro Edoardo , Snurr Randall Q. , Hupp Joseph T. , Arcudi Francesca , Dordevic Luka
Published: October 2024

The semi-hydrogenation of acetylene to ethylene in ethylene-rich gas streams is a high-priority industrial chemical reaction for producing polymer-grade ethylene. Traditional thermocatalytic routes for acetylene reduction to ethylene, despite progress, still require high temperatures and high H2 consumption, possess relatively low selectivity, and use a noble metal catalyst. Light-powered strategies are starting to emerge, given that they have the potential to use directly the abundant and sustainable solar irradiation, but are ineffective. Here we report an efficient, >99.9% selective, visible-light powered, catalytic conversion of acetylene to ethylene. Our catalyst is a homogeneous molecular cobaloxime that operates in tandem with a photosensitizer at room temperature and bypasses the use of non-environmentally friendly and flammable H2 gas feed. The reaction proceeds through a cobalt-hydride intermediate with nearly 100% conversion of acetylene under competitive (ethylene co-feed) conditions after only 50 minutes, and with no evolution of H2 or over-hydrogenation to ethane. We further incorporate the cobaloxime as linker in a metal-organic framework; the result is a heterogeneous catalyst for the conversion of acetylene under competitive (ethylene co-feed) conditions that can be recycled up to six times and remains catalytically active for 48 hours, before significant loss of performance is observed.
The Exception Rights Utilization Strategy to Enhance Defendant's Freedom Protection in Criminal Justice Proceedings
Authors: Sulistyowati Sulistyowati , Maharani Dewi Nadya
Published: October 2024

The criminal justice must be carried out based on the Code of Criminal Procedure. According to Article 156, paragraph (1), the exception is the right of the defendant to answer the indictment given by the Public Prosecutor. The memorandum of objection must be made well when observing the indictment. If there are weaknesses in the indictment, they must be disclosed in the exception appropriately so that the results are optimal in restoring the defendant's human rights that had been deprived, in the form of freedom if the defendant is detained. The case does not proceed as in the Interim Decision number 1473/Pid.Sus/2017/PN Jkt.Sel. When it wants to continue as a case, the prosecutor must make a new indictment. The goal is to optimize so that the rights of the accused remain protected. That then there are efforts of the public prosecutor is a natural thing. The research method in this study is juridical normative. Data collection by making court decisions is also done through literature research.
The Revitalization of Extraordinary Legal Remedies Cassation for Legal Interests in the Criminal Justice System in Indonesia
Authors: Jupriyadi Jupriyadi
Published: October 2024

The decision of judges are not free from errors or mistakes, and often even shows partiality (not neutral) towards certain parties. Extraordinary legal action: cassation for legal purposes can be filed against all decisions that have obtained permanent legal force from other courts, apart from the Supreme Court. Great. The purpose of this research is to determine the factors that cause the Attorney General to rarely use the extraordinary legal remedy of cassation for legal purposes. To revitalize the extraordinary legal effort of cassation for legal purposes so that it can run effectively in the criminal justice system in Indonesia. The findings from this research are that revitalization can be carried out by providing adequate explanations, especially the phrases "legal interests" and "must not harm interested parties" or even eliminating the provisions of Article 359 paragraph (2) of the Criminal Procedure Code, so that it does not give rise to different interpretations and judges can give fair decisions, without being shackled by the phrase "must not harm interested parties".
Relationship Between Single-Leg Vertical Jump and Drop Jump Performance, and Return to Sports After Primary Anterior Cruciate Ligament Reconstruction Using Hamstring Graft
Authors: Ohji Shunsuke , Aizawa Junya , Hirohata Kenji , Ohmi Takehiro , Kawasaki Tomoko , Koga Hideyuki , Yagishita Kazuyoshi
Published: October 2024

Background

After anterior cruciate ligament reconstruction (ACLR), asymmetry is likely to persist in single-leg (SL) vertical jump and drop jump performance than in SL hop distance. However, its relationship with the return to sport (RTS) remains unclear.

Hypothesis/Purpose

This study aimed to determine the association between vertical jump performance after primary ACLR using hamstring tendon autograft and RTS at a pre-injury competitive level.

Study design

Cross-sectional study

Methods

Patients who underwent primary ACLR using hamstring tendon autograft were recruited for this study. Participants who returned to pre-injury competition after ACLR were recruited at least eight months postoperatively. Knee condition was assessed, including joint laxity, range of motion, muscle strength, and knee pain intensity during sports activities. Performance variables were also assessed, including SL hop distance, jump height in SL vertical jump, and reactive strength index (RSI; jump height/contact time) in SL drop jump. Participants were asked to subjectively report whether they had returned to the same level of competition as pre-injury and their perceived sport performance intensity. Those who answered “Yes” to the dichotomous question and had a postoperative subjective athletic performance of > 80% were categorized into the Yes-RTS group. The primary outcome was the ability to achieve RTS at the preinjury level.

Results

Sixty-five patients (female, 35; male, 30) at 13.0 (13.0) [median (interquartile)] months after ACLR participated in this study. Thirty-nine (60%) were assigned to the Yes-RTS group. Regarding knee conditions, the No-RTS group had a significantly higher knee pain intensity, as assessed using a numerical rating scale (p<0.001, effect size -0.45). In the performance tests, the No-RTS group exhibited a significantly lower limb symmetry index of RSI during the SL drop jump compared to the Yes-RTS group (p=0.002, effect size 0.81).

Conclusion

Patients unable to achieve RTS after primary ACLR using hamstring grafts are more likely to exhibit asymmetric performance during the SL drop jump test, suggesting the significance of assessing jump symmetry when evaluating post-ACLR rehabilitation success.

Level of Evidence

3c
Rehabilitation Protocol Variability Following Arthroscopic Bankart Repair and Remplissage for Management of Anterior Shoulder Instability: A Systematic Review
Authors: Villarreal-Espinosa Juan B. , Reinold Michael M. , Khak Mohammad , Shariyate Mohammad J. , Mita Carol , Kay Jeffrey , Ramappa Arun J.
Published: October 2024

Background

Augmentation of an arthroscopic Bankart repair with the remplissage (ABR) procedure has shown to confer a decrease in recurrence rates, yet, at the expense of potentially compromising shoulder motion.

Purpose/Hypothesis

The purpose was to examine clinical studies that described a post-operative rehabilitation protocol after an arthroscopic Bankart repair and remplissage procedure. It was hypothesized that a review of the literature would find variability among the studies and that, among comparative studies, there would be a limited distinction from protocols for isolated Bankart repairs.

Study design

Systematic Review

Materials and Methods

A search was conducted using three databases (PubMed, EMBASE, and CINAHL) according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. The following terms were combined while utilizing Boolean operators: (Bankart lesion OR labral tear) AND (remplissage). Studies evaluating patients after arthroscopic stabilization for unidirectional anterior glenohumeral instability with the addition of the remplissage procedure and at least 1 year follow-up were included for analysis.

Results

A total of 41 studies (14 Level IV, 24 Level III, 2 Level II, and 1 Level I) were included with a total of 1,307 patients who underwent ABR. All patients had <30% glenoid bone loss and a range of 10-50% humeral head size Hill-Sachs lesion. Type and position of immobilization were the most reported outcomes (41/41) followed by time of immobilization (40/41). Moreover, 23/41 studies described their initial post-operative shoulder range of motion restrictions, while 17/41 specified any shoulder motion allowed during this restrictive phase. Time to return to sport was also described in 37/41 of the retrieved studies. Finally, only two of the 27 comparative studies tailored their rehabilitation protocol according to the specific procedure performed, underscoring the lack of an individualized approach (i.e. same rehabilitation protocol for different procedures).

Conclusion

The results of the present systematic review expose the variability among rehabilitation protocols following ABR. This variability prompts consideration of the underlying factors influencing these disparities and underscores the need for future research to elucidate optimal rehabilitation. Based on the results of this systematic review and the senior authors´ clinical experience, a rehabilitation approach similar to an isolated Bankart repair appears warranted, with additional precautions being utilized regarding internal rotation range of motion and external rotation strengthening.

Level of Evidence

Level 3
Clinical Utility of Qualitative Change of Direction Movement Assessment in ACL Injury Risk Evaluation
Authors: Andreyo Evan , Unverzagt Casey , Dos'Santos Thomas , Dawes J. Jay
Published: October 2024

Anterior cruciate ligament (ACL) injuries are complex and influenced by numerous internal and external risk factors that should be considered to effectively mitigate injury and facilitate informed return to sport decision-making. Among these risk factors, movement quality exhibited during sport-specific tasks has been identified as a significant predictor of injury occurrence. Particularly, change of direction (COD) movements, when performed with sub-optimal movement quality, such as knee valgus and lateral trunk flexion, are prominent mechanisms of ACL injury in multidirectional sports. Unfortunately, the formal and objective assessment of COD movement quality is underutilized in clinical and sports practice, with existing methods often confined to expensive, sophisticated laboratory settings impractical for everyday clinicians. The purpose of this clinical commentary is to demonstrate the necessity of integrating COD movement assessments to screen for potential ACL injury risk, particularly among higher-risk populations. The authors will review cost-effective and clinic-friendly objective tests used to qualitatively screen COD movements, such as the Cutting Movement Assessment Score and The Expanded Cutting Alignment Tool. Additionally, this commentary will discuss key considerations when assessing COD movement.

Level of Evidence

5
Research on the Application of PBL + SPOC Blended Teaching Model in Probability and Statistics Course
Authors: Li Hairong
Published: October 2024

To cultivate talents with an exploratory spirit and practical skills in the era of information technology, it is imperative to reform teaching methods and approaches. In the teaching process of the Probability and Statistics course, an application-oriented blended teaching model combining problem-based learning and small private online course was explored. By organizing and implementing online and offline teaching activities based on problem-based learning, a multidimensional process-oriented learning assessment system was established. Practice has shown that this model can effectively enhance classroom teaching effectiveness, benefiting the improvement of students’ overall skills and mathematical literacy.
Construction of Biological Experiment Curriculum System in the Context of Innovation and Entrepreneurship Education
Authors: Tang Li , Zhang Ju
Published: October 2024

Innovation and entrepreneurship education is an important direction for the current reform of higher education and should be included in the professional talent training plan and the construction of the biological experiment curriculum system. Specific measures include in-depth excavation of the connotation of biological experiment teaching courses from the perspective of talent training, building an innovation and entrepreneurship biological experiment curriculum system guided by the needs of social development, establishing a comprehensive and diversified platform for practice and innovation, and constructing a teaching team that integrates innovation and entrepreneurship education and professional education.
Exploration of Interdisciplinary Integration in Teaching Reform of Legal Studies and Auditing
Authors: Hao Lili
Published: October 2024

This paper attempts to explore interdisciplinary integration from four aspects: the necessity of interdisciplinary integration between legal studies and auditing, the difficulties and challenges encountered in this integration, the ideas for teaching reform in the context of interdisciplinary integration, and the expected outcomes. The aim is to achieve an organic integration of legal studies and auditing through systematic teaching reforms, thereby providing students with comprehensive and integrated knowledge and skills training, ensuring the quality of talent cultivation, and adapting to the needs of social development.
A Literature Review on the Identification of Socialist Core Values
Authors: Fan Yangyang
Published: October 2024

Socialist core values are the concentrated expression and highly condensed values of the state, society, and individuals. They are also the embodiment of the values and spiritual consensus and pursuit in the life of the state and society. This article analyzes and summarizes the research results on the identification of socialist core values in China in recent years, mainly sorting out aspects such as the significance of identification, the dialectical relationship between identification and practice, differences in identification levels among different groups, and paths to enhance identification. Finally, suggestions for further deepening future research are proposed.
Discussion on “School is Society” and Its Enlightenment to the Construction of University Environment
Authors: Hao Shiwen , Liu Ruyue
Published: October 2024

The principle of “school is society” indicates that controlling the environment is the only educational method. By transforming the school into a microcosm of society, we can cultivate individuals who possess a social spirit and adaptability, preparing them to thrive in real-world social situations. By analyzing the social performance of colleges and universities in terms of their training objectives for society, research concepts for the development of society, and service consciousness for the improvement of society, as well as the current demand for a proper connection with society, it can be found that taking “school is society” as the guiding ideology for the construction of the university environment tends to be simplified, purified, balanced, broadened, and provided with practical space. This will be beneficial to the development of higher education.
КРИСТАЛЛИЧЕСКАЯ СТРУКТУРА КОМПЛЕКСА ЗОЛОТА(III) С ТЕТРАКИС-(4-ЦИАНОФЕНИЛ)ПОРФИРИНОМ
Authors: Бардина Е.Э. , Макотченко Е.В. , Бирин К.П. , Шремзер Е.С. , Байдина И.А. , Сухих Т.С. , Новиков А.С. , Горбунова Ю.Г. , Гущин А.Л.
Published: October 2024

Методом РСА установлена кристаллическая структура нового комплекса золота(III) с тетракис-(4-цианофенил)порфирином состава [Au(ТCNРР)][AuCl4]×DMF. Структура содержит комплексный катион [Au(ТCNРР)]+ и комплексный анион [AuCl4]–, атом золота(III) в которых находится в типичном квадратном окружении; координационный узел AuN4 и AuCl4 соответственно. Выявлены короткие межмолекулярные контакты Au···Au и Au···Cl между эти комплексными ионами, природа которых изучена с помощью квантово-химических расчётов в рамках теории функционала плотности (ωB97XD/DZP-DKH) и топологического анализа распределения электронной плотности по Бейдеру (QTAIM).
Antimicrobial Potential of Calotropis gigantea Leaf Against Klebsiella pneumoniae in Ventilator-Associated Pneumonia
Authors: Zulfikar Teuku , Siregar Tongku N. , Rozaliyani Anna , Sutriana Amalia
Published: October 2024

Calotropis gigantea or biduri has traditional medicinal properties. However, the effect of C. gigantea leaves in assisting the function of antibiotic-resistant ventilator-associated pneumonia (VAP), particularly caused by Klebsiella pneumoniae, has not been evaluated. The purpose of this study was to identify the active compounds of C. gigantea leaf extracts growing in the coastal area of Alue Naga, Banda Aceh, Indonesia, and assess its antimicrobial potential in preventing microbial resistance. C. gigantea leaves were extracted using three different solvents: ethanol, ethyl acetate, and n-hexane. The three extracts of C. gigantea leaves were analyzed for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the active compounds of C. gigantea were identified using gas chromatography-mass spectroscopy (GC-MS). The dominant bioactive compounds of the C. gigantea extract were enrolled for molecular docking analysis. The results of this study showed that the inhibitory concentration 50% (IC50) of the ethanol extract had a higher antioxidant activity (IC50 value of 3.3 ppm) than the ethyl acetate (IC50 value of 22.97 ppm) and n-hexane (IC50 value of 32.9 ppm). Bioactive compound identification using GC-MS from the three extracts showed similar dominant compounds, which were α-amyrin and lup-20(29)-en-3-ol, and these compounds belonged to the class of triterpenoid derivative compounds. Molecular docking analysis showed that α-amyrin (-9.6 Kcal/mol), β-amyrin (-9.6 Kcal/mol), and epilupeol (-9.2 Kcal/mol) in C. gigantea leaves had higher binding free energy values compared to cefixime (-8.7 Kcal/mol). Thus, it could be concluded that C. gigantea leaf extract is assumed to have great potential as an antimicrobial agent and in preventing microbial resistance, particularly in cases of VAP caused by Klebsiella pneumoniae. Doi: 10.28991/HEF-2024-05-03-010 Full Text: PDF
Comparative analysis of types of collective housing depending on social conditions, the presence of common goals and the duration of residence
Authors: Pavlyuk Alena , Shirokova Ol'ga
Published: October 2024

In Russian practice, there are examples of negative experiences with collective housing, such as communal apartments. However, given certain conditions and factors, collective housing can motivate creation and inspire experiments. The article examines three types of collective housing, varying in length of stay, presence or absence of common goals and values, voluntary or forced participation, size of personal space, and various financial capabilities. Communal apartments, corridor and block-type dormitories, and the organization of short-term festivals are considered as examples. A matrix of evaluation criteria has been formed for each type.
The model for automating the management of the building inspection process at the operational stage
Authors: Sluchevskij Leonid , Knyazeva Natal'ya , Orekhov Aleksej
Published: October 2024

The article presents a study of the possibilities of automating the inspection processes of load-bearing building structures, with a special emphasis on the use of CRM systems with specialized modules. Practical examples of the implementation of such systems in the activities of construction organizations are analyzed. The necessity of engineering and technical inspection of buildings at all stages of their life cycle is discussed, based on the relevance of information on the technical condition of structures to ensure the safety of users. A process map has been developed covering various stages, such as data preparation, task creation, accounting and reporting documentation, using Bitrix 24. The key actions involved in each stage are identified, as well as the role and interaction of various departments of the organization. The importance of using BPMN for business process modeling is emphasized, which makes it possible to improve the management and coordination of work, reduce the risks of errors and increase the deadline for completing tasks. The work offers a systematic approach to conducting building surveys, covering key aspects of automation and process organization, which can significantly improve the quality and efficiency of surveys in the construction industry. Such modeling makes it possible to optimize the interaction between specialists, minimize the likelihood of errors and speed up the execution of work, ensuring systematization and control at all stages of the examination.
ON THE QUESTION OF THE CONCEPT AND GUARANTEES OF LEGALITY
Authors: Shapoval Nataliya , Lysenko Viktoriya
Published: October 2024

The article reveals the concept of legality as a social and legal phenomenon. When establishing the content of the category of legality, an important question is through what guarantees its reality is ensured. The article discusses general and special guarantees, under the influence and assistance of which the regime of legality is implemented, protected, and in case of violation, restored. Special attention is paid to measures to strengthen the rule of law. The definition of “legality” is introduced into scientific circulation.
Patrones dietéticos en el aumento de masa muscular en adultos mayores: Una revisión sistemática
Authors: Collado Carrera Cristell , Priego Álvarez Heberto Romeo , Magaña Castillo Margarita , González Javier Flor del Pilar
Published: October 2024

Introducción: El envejecimiento es un proceso natural que trae consigo síndromes propios de la edad como la pérdida de masa muscular, en el que es necesario el consumo de energía, proteínas, aminoácidos, vitaminas para la obtención de este. No se requiere de un solo nutrimento sino del conjunto de todos ellos para la síntesis de músculo que se pueden obtener por medio de patrones dietéticos saludables. Objetivo: Describir la efectividad de los diferentes patrones dietéticos que sean similares a la dieta de la milpa sobre el aumento de masa muscular en el adulto mayor. Material y Método: Se realizó una revisión sistemática de acuerdo con la guía PRISMA 2020, en 3 bases de datos con las palabras dieta, patrones alimentarios, músculo y adulto mayor en inglés. Resultados: Se identificaron 4 revisiones sistemáticas que cumplieron con los criterios de inclusión, participación de adultos mayores y relación entre dieta y masa muscular. Conclusión: Los patrones dietéticos regionales saludables son parte importante para el aumento y preservación de la masa muscular a lo largo de la vida, hacen falta más estudios con respecto a patrones alimentarios saludables como la dieta de la milpa para llenar el vacío de información existente en este tema.
Use of a Set-up Fee to Encourage Survey Participation and Electronic Health Record Submission for a National Health Care Survey
Authors: Cummings Nicole A. , Onukwufor Joy E. , Ward Brian W. , Williams Sonja N.
Published: October 2024

In 2021, the National Ambulatory Medical Care Survey Health Center (NAMCS HC) Component modernized its data collection and began collecting clinical visit data from health centers using transmission of electronic health record (EHR) data. With this redesign, there are potential cost implications for a health center to participate. Beginning in 2021, a one-time set-up fee (i.e., payment) of up to $10,000 was offered to centers who participated in the NAMCS HC Component. Starting in 2022, a Set-up Fee Questionnaire was used to capture data on the use of this money. Results show on average the fee appeared adequate in covering participation costs, with the fee most often used to cover costs of health center and EHR vendor information technology staff. Although this fee was offered only during the initial year of participation, retention rates for centers appeared high. Implications from the findings of this case study on use of a set-up fee in establishment surveys are also briefly discussed.
THE FRAGMENTATION OF IDENTITY: COMMUNAL VIOLENCE AND PERSONAL TRAUMA IN CHAMAN NAHAL’S AZADI
Authors: Shahjadi  , Gupta Monika
Published: October 2024

This paper analyzes the fragmentation of personal and collective identities in Chaman Nahal’s Azadi, focusing on the emotional and psychological impacts of the Partition of India in 1947. Set against the backdrop of communal violence, the novel examines the trauma experienced by its protagonist, Lala Kanshi Ram, a prosperous Hindu merchant forced to flee his home in Sialkot due to religious tensions. The paper explores how Kanshi Ram’s displacement erodes his identity, transforming him from a respected figure into a displaced refugee struggling to adapt to post-Partition India. The novel emphasizes how communalism fractures identities, forcing characters to redefine themselves within new religious and national contexts. The analysis further highlights the theme of emotional rebirth as the characters, now refugees, grapple with their losses and strive to rebuild their lives in a fragmented society. By focusing on themes of identity, trauma, and resilience, this paper asserts that this novel is not just a recounting of historical events but a profound exploration of the emotional and psychological impact of Partition on both individuals and the wider society.
THE PERSONAL AND THE COLLECTIVE: A STUDY OF THE EXILE OF KASHMIRI PANDITS THROUGH MULTIPLE GENRES
Authors: Bhat Javaid
Published: October 2024

This paper will probe the meaning of “home” as a subjective category for healing through a comparative examination of selected poems by Lalita Pandit Hogan (1950- ) and two documentaries Tell them: ‘The Tree they had planted has now Grown’ and The Lost Paradise : A documentary on plight of Kashmiri Pandits by Ajay Raina and Akshay Labroo respectively. Both the poems and the documentaries summon the notion of Home as a potential “end”, with the latter deliberately invested in the double meaning of loss and purpose. In identifying the “end” of return to home, the two genres fuse the personal with the trans-personal, blend the concrete with the political, mix the haunting memory of past with a confusing present and an uncertain future. The welding of diverse poles in each evokes the tragedy of the unending conflict in modern Kashmir. While the erasure of hope in the “end” of home is strongly present in Lalita Pandit’s poems, the documentaries appeal to the political establishment to rend the wall between the despair of present and the free home of the future. For Raina and Labroo, as with Pandit, the present is rife with desolation and fear. However, while documentaries hint at the transience of the Now, Pandit, rooted in the fear of the radical other in the altered political scenario, evokes the permanent migration of the Self from the healing home. Both cautiously present the past as far more adjusting and accommodative than the insularly exclusivist perceptions of the present saturated with the growing cries of liberation from a country with which her Hindu community has deep cultural connections. In all, personal expression transcends the individual limits to acquire a putative representative voice for their respective cultural configurations. Neither is dedicated to a narrow essentialist rendering of those configurations.
OPTIMIZING PIGMENT PRODUCTION FROM PENICILLIUM SP. FOR SUSTAINABLE SILK DYEING
Authors: Naaz Shumaila , Gupta Charu , Aggarwal Sunita
Published: October 2024

This study explores the use of microbial pigments from Penicillium sp. as a sustainable alternative to synthetic dyes in textile dyeing, focusing on optimizing pigment production and assessing color fastness on silk. Static Potato Dextrose Broth (PDB) at 28°C produced the highest concentration of red pigment after 27 days of incubation, with an optical density (O.D) of 1.010 at λmax = 530 nm. In contrast, 15°C resulted in slower pigment production (O.D = 0.860), and 37°C showed negligible growth. Adjusting the PDB pH to 5 increased pigment yield, aligning with previous studies showing Penicillium sp. thrive in acidic conditions. The final broth pH decreased to 4.0 due to organic acid production by the fungus.Silk samples dyed with these pigments were evaluated for color strength and fastness. The colorimetric values indicated moderate color intensity (K/S = 4.25) with a bright, pastel-like appearance (L* = 81.23), and a warm reddish-yellow hue (a* = 9.23, b* = 6.48). Fastness tests showed excellent performance for dry rub (rating 5), good results for wet rub (rating 4), and favorable wash fastness (rating 4 for staining and color change). However, light fastness was lower, suggesting potential fading under prolonged exposure.Overall, the study identifies Penicillium sp. as a promising source of natural dyes for silk, with optimized fermentation conditions (PDB, 28°C, pH 5, 27 days) leading to high pigment yield and strong fastness performance, offering a sustainable alternative to synthetic dyes in textiles.
IR 5.0: A CONCEPTUAL STUDY ON THE IMPLICATIONS FOR EMPLOYER BRANDING FOR GEN Z
Authors: Anute Nilesh , Nagre Ajay , Mude Girish
Published: October 2024

This paper explores the intersection of Industry 5.0 (IR 5.0) and employer branding, with a specific focus on how organizations can leverage IR 5.0 principles to attract, engage, and retain Generation Z (Gen Z) talent. The study aims to provide insights into how the human-centric and sustainability-focused aspects of IR 5.0 reshape employer branding strategies, aligning them with the values and expectations of Gen Z. A conceptual framework was developed by reviewing existing literature on Industry 5.0, employer branding, and generational workforce preferences, particularly those of Gen Z. The paper employs a qualitative approach, synthesizing key themes from the literature to propose strategic employer branding adaptations. Insights were gathered from case studies, secondary data, and industry reports to illustrate real-world applications and potential outcomes. The study identifies several key areas where IR 5.0 enhances employer branding for Gen Z, including the emphasis on personalized work experiences, sustainability, ethical practices, innovation-driven cultures, and human-machine collaboration. It also highlights Gen Z's demand for flexible work arrangements, continuous learning, and purpose-driven roles. These alignments present opportunities for companies to differentiate themselves in a competitive job market. However, a successful alignment requires a comprehensive and authentic integration of IR 5.0 principles into the company’s branding strategy. The conceptual nature of this study limits empirical testing of the proposed framework. Further quantitative research and case studies are needed to validate the findings across different industries and regions. Additionally, rapid technological advancements may require continuous updates to the proposed model as IR 5.0 evolves. Organizations looking to enhance their employer brand and appeal to Gen Z should integrate IR 5.0 principles into their strategic approach. This includes fostering a culture of sustainability, promoting lifelong learning, and leveraging advanced technologies for human-centric innovation. Adopting these practices can strengthen employer branding and attract tech-savvy, value-driven Gen Z talent. This paper is among the first to conceptually link Industry 5.0 with employer branding for Gen Z, offering fresh insights into how the next industrial revolution impacts talent management strategies. It adds to the emerging discourse on how technological and human-focused innovations can reshape workforce dynamics and recruitment practices.
Formulasi Serbuk Wedang Tahu dan Pendugaan Umur Simpan Menggunakan Metode Kadar Air Kritis
Authors: Palupi Nurheni Sri , Husna Aliya , Kusnandar Feri , Sitanggang Azis Boing
Published: October 2024

Indonesia silken tofu dessert is a traditional dish made from silken tofu and ginger sauce. To enhance its shelf life, this study explored the development of silken tofu dessert into a powdered form. Traditionally, silken tofu is coagulated using calcium sulfate (CaSO₄), but there has been little research on the optimal concentration of CaSO₄ necessary for forming curd in powdered silken tofu comparable to the traditional version. This study aimed to identify the ideal concentration of CaSO₄ as a coagulant to be added to powdered silken tofu and to estimate its shelf life using the critical moisture method. Sensory testing was conducted to select the appropriate concentration of CaSO₄, comparing different levels to a control method. The results revealed significant differences between the powdered silken tofu dessert and the traditional counterpart. Among the three CaSO₄ concentrations tested (3, 5, and 7%), the dessert prepared with 3% CaSO₄ exhibited the closest resemblance to the traditional silken tofu dessert. A single serving of this powdered silken tofu dessert provides 125 kcal of total energy, accounting for 12% of the recommended daily allowance (RDA) for protein, 3% for total fat, and 6% for carbohydrates. When packaged in metallized plastic and stored at a relative humidity of 78% and a temperature of 30 °C, the shelf life of the powdered silken tofu dessert is extended up to 12 months.