bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Learning Automata and Genetic Algorithm-based Energy Efficient and Reliable Data Delivery Mechanism in Wireless Sensor Networks
Authors: Gudla Sateesh , Siripurapu Sridhar
Published: January 2025

Wireless sensor networks (WSNs) pose many challenges- in spite of their crucial role in data transmission and reception covering wide range of applications. However, in adverse environmental conditions, wireless link instability prevents sensed data from reaching the sink node as well as leading to packet loss. In order to improve reliability of data delivery, retransmission and redundancy-based strategies can be employed. Nevertheless, these strategies lead to higher energy consumption with longer packet delivery delays. Therefore, ensuring energy efficiency and consistent delivery of data is of primary concern with WSNs. The proposed research work is predominantly focused on the route construction by selecting best resourceful nodes in terms of all the vital parameters of sensor nodes like residual energy, buffer space, distance & link quality (that leads to packet dropping). This work presents a routing mechanism for WSNs that leverages learning automata (LA) and genetic algorithm (GA). At first LA is hired to generate initial population. Further, GA is employed to establish energy efficient and reliable routes. Moreover, a novel fitness function is developed with due consideration of parameters like residual energy, buffer space, distance and link quality. Thus, this approach guarantees best possible parent chromosomes for the genetic operations. Simulation results depict that this algorithm condenses energy consumption, diminishes data delivery delays, decreases the number of data transmissions, while outspreading lifetime of network.
Synergistic Potential of Thymoquinone and Caffeic Acid in Experimental Ulcerative Colitis: A Biochemical and Histopathological Investigation
Authors: Ersak Can , Ergüder Ender , Erguder B.Imge , Altiner Saygin , Pekcici M. Recep
Published: January 2025

Aim
This study aims to model ulcerative colitis in rats using acetic acid and monitor colitis development with the "Disease Activity Index (DAI)." Additionally, the clinical, biochemical, and histopathological effects of thymoquinone (TQ) and caffeic acid phenethyl ester (CAPE) on this model are examined.
Materials and Methods
The study used 40 male Wistar Albino rats, weighing between 190–303 grams. The rats were divided into five groups of 8 each: Group 1 (Control) received intraperitoneal 0.9% saline solution for 5 days; Group 2 (Colitis) received acetic acid to induce colitis and 10% ethanol solution intraperitoneally for 5 days; Group 3 (TQ) received acetic acid to induce colitis and intraperitoneal thymoquinone (10 mg/kg/day) for 5 days; Group 4 (CAPE) received acetic acid to induce colitis and intraperitoneal caffeic acid (10 micromol/kg/day) for 5 days; Group 5 (TQ + CAPE) received acetic acid to induce colitis and intraperitoneal thymoquinone and caffeic acid for 5 days. On the 5th day, rats underwent laparotomy under anesthesia, colectomy was performed, and colon samples were taken for biochemical and histological analysis. Serum samples were also collected for biochemical analysis.
Results
Significant differences were observed in the Disease Activity Index, TNF-α, catalase, glutathione peroxidase, IL-10, and MDA, indicating a balance between oxidant and antioxidant parameters. CAPE was found to have a higher anti-inflammatory effect than TQ histopathologically. The combined application of CAPE and TQ showed a synergistic effect, reducing oxidative stress markers and enhancing antioxidant levels.
Conclusion
The hypothesis of this study is that CAPE and TQ will effectively reduce inflammation in an experimental colitis model induced by acetic acid. The results largely support this hypothesis, showing that CAPE has a higher anti-inflammatory efficacy than TQ and that their combined use is more effective in reducing inflammation. These findings suggest that CAPE and TQ could be a potential combination for colitis treatment and should be considered for clinical applications. This study provides new insights into the use of anti-inflammatory agents in experimental colitis models and highlights the potential advantages of combining CAPE and TQ in clinical settings.
Cystitis Glandularis: Analysis of Multiparametric MRI Appearance in 40 Patients.
Authors: Weng Bei , Lin Yingyu , Wen Zhihua , Guo Yan , Wang Huanjun , Kong Lingmin , Cai Qian , Lin Jian
Published: January 2025

Purpose
Cystitis glandularis (CG) is a rare, benign proliferative and metaplastic disorder of the bladder mucosa. However, CG is often confused with bladder cancer due to similar clinical symptoms and imaging findings. The aim of this study was to investigate the multiparametric MRI manifestations of CG, with the goal of improving the diagnostic accuracy of CG.
Methods
Patients with pathologically confirmed CG who underwent pelvic MRI between November 2011 and September 2023 were retrospectively reviewed. The MR imaging characteristics of CG were analyzed and summarized. Additionally, apparent diffusion coefficient (ADC) values were measured to assess the diffusion restriction within the lesions.
Results
A total of 40 patients (mean age, 49.4 years ± 14.4 [SD]; 35 male) with CG were analyzed. The lesions were predominantly located in the trigone and/or bladder neck (36 of 40, [90.0%]). A characteristic multi-layered structure, referred to as the “floating water weeds sign”, was observed in 29 lesions (72.5%) on T2WI, with or without bubble-like high signal intensity. Based on MRI morphology, CG were classified into four types, and most patients showed nodular thickening type (24 of 40, 60.0%). The majority of lesions (34 of 40, 85.0%) exhibited marked enhancement, with 24 patients (60.0%) showing linear contrast enhancement on the lesion surface. Most lesions (36 of 40, 90.0%) showed no or mild diffusion restriction with a mean ADC value of 1.67 ± 0.38×10− 3 mm2/s.
Conclusion
There are several representative characteristic MRI findings for CG, especially on T2WI and DWI, which are valuable for differential diagnosis.
ATOH8 upregulated by IL-6/STAT3 attenuates endoplasmic reticulum stress and promotes oxaliplatin resistance in gastric cancer
Authors: Li Shaowei , Ma Zhenfeng , Li Guanjun , Liu Xiaohan , Wang Jiao , Sun Fei , Liang Bishan , Wang Yawen , Wang Chunlin , Rong Xiaoxiang , Wu Jianhua , Wu Qijing , Shi Yulu , Liao Wangjun , Shi Min , Tan Yujing , Huang Qiong
Published: January 2025

Gastric cancer (GC) is a highly malignant tumor, and oxaliplatin is widely used in its chemotherapy. However, drug resistance limits its clinical effectiveness. This study aimed to identify potential therapeutic strategies to overcome oxaliplatin resistance in GC. RNA sequencing was conducted to compare oxaliplatin-resistant GC cells with their parental counterparts. Using the Limma package, we identified an immunosuppressive microenvironment and six key transcription factors associated with resistance, with ATOH8 showing the most significant correlation with oxaliplatin resistance. Functional assays revealed that ATOH8 expression was linked to increased drug resistance, and its knockout induced upregulation of endoplasmic reticulum (ER) stress-related pathways. Mechanistically, we found that IL-6 facilitated nuclear translocation of STAT3, which subsequently upregulated ATOH8 expression. This established a negative STAT3/ATOH8/ER stress regulatory axis that contributes to chemotherapy resistance. In conclusion, ATOH8 acts as a key regulator of ER stress and chemotherapy resistance in GC. Targeting the STAT3/ATOH8 axis may offer a new therapeutic approach for overcoming resistance in advanced GC.
Diversity and Spatio-seasonal Distribution of Aquatic Macrophytes inMoutore Reservoir, West Bengal
Authors: BISWAS ANUPA , Behera Samarendra
Published: January 2025

A study was conducted to find out the biodiversity of macrophytes and their seasonal variation in the beautiful perennial reservoir during October, 2021 to September, 2022. The reservoir drains the excess water through canal in Damodar River which is passing through northern side of the reservoir. During the study period, a total of 10 species of macrophytes were recorded. The diversity index i.e. Margalef Richness Index (d=0.62) and Pielou’s evenness Index (J’=0.9) was highest in summer months, Shannon and Weiner Index (H’=1.57) and Simpson’s Index (λ’=0.77) was highest in monsoon months respectively. Lowest value for all the Index was observed in rainy season. The aquatic macrophytes are naturally occurring, well adopted to the environment and thus play an important role to reduce the water pollution by absorbing the nutrients of water. The surrounding villagers use the reservoir as a source of water for drinking, washing, bathing, household activity as well as important source of income generation by harvesting of fish and also open defecation on reservoir bank resulting anthropogenic source of pollution and enrichment of nutrients for macrophytes, gradually degrading the quality of reservoir. The spatial distribution of macrophytes as well as annual and seasonal variability is essential for planning, development and management of the reservoir.
Global disease burden of non-Hodgkin lymphoma in adolescents and young adults aged 15 to 39 from 1990 to 2021
Authors: Tang Bin , Zhu Yuqing , Xiao Qifan , Kang Mande
Published: January 2025

Background
Non-Hodgkin lymphoma (NHL) can occur at any age but is more common in middle-aged and older adults. Although the incidence of NHL is lower in adolescents and young adults (AYAs) aged 15–39 years, certain types have seen an increase in incidence in recent years. However, specific data remains incomplete, with regional and population-based differences.
Methods
This study, based on the latest global burden of disease data from 2021, provided a comprehensive analysis of the incidence, mortality, disability-adjusted life years (DALYs), and associated risk factors for NHL in AYAs aged 15–39 years, considering multiple dimensions such as age, gender, social-demographic index (SDI), and nationality.
Results
From 1990 to 2021, the global incidence of NHL in AYAs aged 15–39 years increased from 1.75 per 100,000 in 1990 to 2.15 per 100,000 in 2021. However, both mortality and DALYs showed a declining trend. Specifically, mortality decreased from 0.79 per 100,000 in 1990 to 0.71 per 100,000 in 2021, while DALYs dropped from 49.75 per 100,000 in 1990 to 44.57 per 100,000 in 2021. The incidence of NHL was significantly higher in high SDI regions compared to low SDI regions. The primary risk factor associated with NHL mortality and DALYs was a high body mass index (BMI)
Conclusion
Over the past 32 years, the global disease burden of NHL in AYAs aged 15–39 years has increased, with significant differences in burden levels across regions with varying SDI.
Alerta vermelho: relato extensionista de um projeto sobre saúde menstrual
Authors: OLIVEIRA Marília Kárita de , SANTOS Sandylla Sabrinna Souza , MIRANDA ⁠Isabela de Almeida , BEZERRA ⁠Ingrid Fernandes Borges , SANTOS Lorena Marques , FRANÇA ⁠Layla Camargo Campos , COSTA Yasmin Godoy , LIMA Bruno Cassiano de
Published: January 2025

Falar sobre menstruação, mesmo nos dias atuais, ainda é um tabu. Nesse contexto, o presente estudo tem como objetivo identificar como o projeto de extensão “Alerta vermelho: um olhar humanizado sobre a saúde menstrual” contribuiu para levar informações aos alunos de uma escola estadual. O projeto é uma parceria entre universidade e sociedade através das Ligas Acadêmicas de Humanização e Saúde da Mulher de uma universidade goiana e uma escola estadual do município de Goianésia-GO. Por meio da interação dialógica, interdisciplinaridade e interprofissionalidade, indissociabilidade ensino-pesquisa-extensão foi possível gerar impacto na formação de acadêmicos de medicina e transformação social. Por fim, é válido ressaltar que o projeto não apenas contribuiu para a disseminação de saberes científicos sobre o ciclo menstrual, mas também promoveu a quebra de paradigmas, a conscientização sobre saúde íntima e a formação de uma comunidade mais informada e colaborativa.
Thorite: An Oddity in Phase Stability Amongst the Zircon-Structured Orthosilicates at High Pressures
Authors: Strzelecki Andrew C. , Baker Jason L. , Chariton Stella , Zhao Xiaodong , Prakapenka Vitali , Bollinger David , Ahmed Sohan , Fortner Jeffrey , Szenknect Stephanie , Mesbah Adel , McCloy John S. , Yoo Choong-Shik , Ewing Rodney C. , Dacheux Nicolas , Xu Hongwu , Guo Xiaofeng
Published: January 2025

Synthetic thorite and huttonite, two polymorphs of ThSiO4, were investigated by a combination of in situ high-pressure synchrotron X-ray powder diffraction and in situ high pressure Raman spectroscopy. The average onset pressure of the thorite-to-huttonite transition was determined to be 6.6 ± 0.2 GPa, using both techniques. The bulk moduli of thorite and huttonite were determined to be 139(9) and 246(11) GPa, respectively, by fitting their unit-cell volume data to a second order Birch-Murnaghan equation of state (EOS). Based on its bulk modulus, thorite is the most compressible zircon-structured orthosilicate, as it has the largest unit cell volume among tetravalent metal orthosilicates. The pressure derivatives of the vibrational modes of thorite were found to be consistent with those previously reported for other orthosilicates (e.g., zircon, hafnon, stetindite, and coffinite), while having the smallest Grüneisen parameter. A new P-T phase diagram for ThSiO4 is proposed, where the boundary of the thorite → huttonite transition is: P(T) = (7.8 ± 0.9 GPa) − (0.006 ± 0.002 GPa/K)T. Based on the new P-T phase diagram, we further estimated the enthalpy of formation of huttonite, ΔHf,ox, to be 0.6 ± 6.0 kJ/mol, suggesting its metastability and rare locality in nature.
Theory of kinetically-constrained-models dynamics
Authors: Perrupato Gianmarco , Rizzo Tommaso
Published: January 2025

The mean-field theory of Kinetically-Constrained-Models is developed by considering the Fredrickson-Andersen model on the Bethe lattice. Using certain properties of the dynamics observed in actual numerical experiments we derive asymptotic dynamical equations equal to those of Mode-Coupling-Theory. Analytical predictions obtained for the dynamical exponents are successfully compared with numerical simulations in a wide range of models, including the case of generic values of the connectivity and the facilitation, random pinning and fluctuating facilitation. The theory is thus validated for both continuous and discontinuous transitions and also in the case of higher order critical points characterized by logarithmic decays.
Errors and optimization of management of patients with chronic lumbalgia: Discussion based on the clinical observation
Authors: Mukhametzyanova A. Kh. , Parfenov V. A.
Published: January 2025

Chronic nonspecific low back pain (chronic lumbalgia) is one of the most common causes of disability in the adult population. Currently, effectivemethods of treatment of chronic nonspecific lumbalgia have been proposed, which include an educational program, kinesiotherapy, psychologicalmethods of treatment and optimization of drugtherapy. However, these methods are not often used in real clinical practice, which reflects the observation of a 52-year-old patient who had no positive effect from therapy for 6 months. According to the MRI data, the patient had herniated discs at the level of the lower lumbar discs, with which the patient associated a persistent pain effect. However, the examination revealed signs of damage to the facet joints and sacroiliac joint, which were of leading importance as an anatomical cause of pain. The patient also had emotional disorders, the phenomenon of catastrophization, and painful behavior. An educational conversation was held with the patient, therapeutic exercises were selected, Novema in the afternoon and Novema Night in the evening were prescribed as a non-steroidal anti-inflammatory drug. After 7 days, the pain decreased significantly, sleep improved, adherence to therapeutic gymnastics increased, after 1.5 months the pain syndrome regressed, the patient became active as before the disease. The issues of optimizing the management of patients with chronic lumbalgia and the possibility of widespread implementation of an integrated approach in clinical practice are discussed.
Late diagnosis of spinal muscular atrophy, primary symptoms of the disease according to the patient registry of the SMA Families Foundation
Authors: Artemyeva S. В. , Papina Yu. О. , Germanenko O. Yu.
Published: January 2025

Introduction. Spinal muscular atrophy 5q is a common childhood disease in the practice of a pediatrician and pediatric neurologist. Despite the introduction of neonatal screening in the Russian Federation since 2023, there is a cohort of patients who were not included in neonatal screening and the relevance of knowledge of the clinical symptoms of SMA remains.

Aim. To study the reasons for delayed diagnosis of spinal muscular atrophy in the Russian Federation.

Materials and methods. We analyzed the data of the registry of 1452 patients with SMA: the time of delay in diagnosis from the onset of the first clinical symptoms, identified the first clinical symptoms and analyzed erroneous primary diagnoses that increased the time of correct diagnosis. Patients were divided into two groups: group 1 of patients (1170) born before 2019, the second group of patients (274) born from 2019 to 2023. An analysis of the medical records of 330 patients with SMA observed at the Veltischev Scientific Research Institute was conducted in order to analyze the clinical symptoms of SMA that were underestimated by primary care physicians and led to a delay in correct diagnosis.

Results. In the 1st group of patients, 146 patients with SMA type 1, 531 SMA type 2, 493 – SMA type 3, 8 – SMA type 4 were registered. The delay in diagnosis was 4 months, 2 years 4 months, 5 years 2 months, 11 years, respectively. In the 2nd group of patients, 176 patients with SMA type 1, 81 – SMA type 2, 17 – SMA type 3 were registered. The delay in diagnosis was SMA1 – 2 months, SMA2 – 6 months, SMA3 – 6 months. Since 2019, there has been a significant decrease in the delay in diagnosis, especially for SMA types 2 and 3 up to 6 months. The primary and most significant clinical symptoms for patients with different types of SMA are determined.

Conclusions. Underestimating of clinical symptoms of spinal muscular atrophy leads to late molecular genetic diagnosis of the disease. The identified initial clinical signs of spinal muscular atrophy of different types will allow primary care physicians to suspect the disease in time and refer patients for confirmatory molecular genetic diagnostics.
coordenador(a) de ensino do NEI/CAp-UFRN:
Authors: Fonseca Silvia Cristiane Vieira , Silva Piedade Beatriz Ferreira de Almeida , Almeida Cibele Lucena de , Melo Elda Silva do Nascimento
Published: January 2025

O presente artigo originou-se de dez observações realizadas durante a disciplina “Atividade Especial Coletiva Estágio Supervisionado III, em Coordenação Pedagógica”, realizada no Núcleo de Educação da Infância, Colégio de Aplicação da Universidade Federal do Rio Grande do Norte em 2018. A pesquisa tem por finalidade compreender qual o papel do(a) coordenador(a) pedagógico(a) na efetivação de práticas inclusivas realizadas na escola da infância, considerando a diversidade apresentada na instituição educativa. Para tanto, realizou-se um estudo de caso de natureza qualitativa, adotando-se como instrumentos para a construção dos dados, a observação e o registro em diário de campo. O referencial teórico consultado centralizou-se em Almeida (2005), Freire (1996), Mantoan (2015) e Orsolon (2005). Como resultado, verificou-se que as ações desenvolvidas pelas coordenadoras de ensino da escola possuem uma perspectiva inclusiva,pois os partícipes da instituição (crianças e servidores) têm seus direitos e subjetividades considerados desde o planejamento até a execução das experiências pedagógicas.
Pengaruh Harga, Lokasi, Keamanan, Kenyamanan, Dan Fasilitas Terhadap Minat Sewa
Authors: Agriansyah Ahmad
Published: January 2025

As a city with the highest number of university students in East Java, Malang has the most users of Mamikos, a platform for room-rent seekers. However, anxiety still hampers the application’s users and partners, mostly caused by price, location, security, comfort, and facility. The objective of this research is to identify the effects of price, location, security, comfort, and facility on the intention of university students in Malang City to rent rooms via the platform. The respondents of this quantitative explanatory research were selected using purposive sampling technique, resulting in 400 people. The validity, reliability and classical assumption tests were conducted in the Statistical Package for the Social Science (SPSS), while the data analysis was performed using multiple linear regression. The hypothesis testing was held to assess the model’s feasibility and the partial effects. Based on the hypothesis testing, this study finds that price, location, security, comfort, and facility partially have some effects on the intention to rent rooms via Mamikos.
 
Abstrak
Kota Malang sebagai kota dengan jumlah mahasiswa terbanyak se-Provinsi Jawa Timur mengakibatkan tingginya jumlah pengguna platfrom Mamikos. Namun, masih banyak keresahan yang dialami oleh pengguna dan mitra dalam menggunakan platform Mamikos terutama pada aspek harga, lokasi, keamanan, kenyamanan dan fasilitas. Penelitian ini bertujuan untuk mengetahui pengaruh harga, lokasi, keamanan, kenyamanan dan fasilitas terhadap minat sewa melalui platfrom Mamikos (studi pada mahasiswa di Kota Malang). Jenis penelitian ini adalah explanatory research dengan metode kuantitatif. Penelitian ini menggunakan sampel sebanyak 400 responden dan pengambilan sampel menggunakan teknik purposive sampling. Penelitian ini menggunakan Statistical Package for the Social Sciences (SPSS) untuk melakukan uji validitas, uji reliabilitas dan uji asumsi klasik. Teknik analisis data menggunakan uji regresi linear berganda. Uji hipotesis dilakukan untuk menguji hipotesis kelayakan model dan pengaruh secara parsial. Berdasarkan hasil pengujian hipotesis diperoleh data variabel harga, lokasi, keamanan, kenyamanan dan fasilitas masing-masing berpengaruh terhadap minat sewa indekos pada platfrom Mamikos.
Evaluating Whether Nonimmersion Virtual Reality Simulation Training Improves Nursing Competency in Isolation Wards: Randomized Controlled Trial
Authors: Zhang Dandan , Fu MuLi , Zhang Jianzhong , Li Yuxuan , Chen Li , Chen Yong-Jun , Zhong Zhefeng , Zhang Yin-Ping
Published: January 2025

Background

During infectious disease outbreaks such as the COVID-19 pandemic, nurses are crucial in patient care and public health safety; however, they face challenges such as inadequate training and high stress in isolation wards. Virtual reality (VR) technology offers innovative training solutions to enhance nurses’ clinical skills and preparedness. However, extensive studies on its effectiveness in isolation ward environments are still limited.

Objective

This study aims to develop a nonimmersive VR (NIVR) simulation training program for isolation wards and further validate its feasibility and training effectiveness in aiding nurses in adapting to isolation ward settings.

Methods

This study was a prospective, parallel, open-label, randomized controlled trial. A total of 90 nurses from 3 hospitals in China were randomly assigned to either the control or intervention group, with 45 (50%) individuals in each group. Both groups received training on isolation ward layout and nursing procedures. The control group underwent a 4-hour conventional training session consisting of 2 hours of face-to-face lectures and 2 hours of ward visits. The intervention group received a 4-hour NIVR simulation training session. Subsequently, both groups completed approximately 4 hours of emergency drills and assessments.

Results

After the intervention, there were no significant differences in theoretical test or performance assessment scores between the 2 groups (t88=–0.30, P=.75; Cohen d=–0.06; z score=0.00, P>.99), using a 2-tailed t test. However, the intervention group completed 6 tasks faster than the control group (t88=5.10, P<.001; Cohen d=1.08), with an average reduction of about 3 minutes (control group: mean 43.91, SD 2.99 min; intervention group: mean 40.77, SD 2.85 min). Notably, they completed task 3 (patient reception inward) and task 6 (exiting the isolation area) significantly quicker (t88=3.22, P=.002; Cohen d=0.68; t88=3.03, P=.003; Cohen d=0.64, respectively), with no significant differences for the other tasks.

Conclusions

This study highlights the potential of NIVR simulation training for nurses working in isolation wards. Although NIVR simulation training does not significantly surpass traditional methods in imparting theoretical knowledge, it does reduce task completion time for specific activities. Its capacity for safe, repetitive practice and realistic scenario simulation makes NIVR a valuable tool in medical education. Further research and optimization of VR simulation training programs are recommended to enhance nurses’ practical skills and pandemic preparedness.

Trial Registration

Chinese Clinical Trial Registry ChiCTR240083155; https://www.chictr.org.cn/hvshowproject.html?id=250356&v=1.0
Exploring Youth Perspectives on Digital Mental Health Platforms: a Qualitative Descriptive Study (Preprint)
Authors: Daniel Sarah , Volko Lauren , Bassi Emilie , Hews-Girard Julia , Bright Katherine , Barker Marianne , Norman Lia , Pitson Karina , Henry Geneca , Soufi Sumaya , Omorotionmwan Efrem , Fersovitch Melanie , Stamp Leanne , Moskovic Karen , Johnson David , Dimitropoulos Gina
Published: January 2025

BACKGROUND

The increasing prevalence of mental health disorders among youth underscores the need for accessible and effective interventions. Digital mental health (dMH) platforms like Innowell offer promising solutions by increasing access to mental health care for young people. However, understanding youth perspectives on these platforms is crucial for ensuring successful implementation and sustained engagement.

OBJECTIVE

This study aimed to explore youth perspectives on the implementation of the Innowell platform, identifying key factors influencing uptake, engagement, and long-term retention.

METHODS

A qualitative descriptive approach was used to examine youth perspectives. Data were collected through nine focus groups and one interview, involving 39 participants aged 15-24 years from urban (59%) and rural (41%) communities in Alberta, Canada. Participants were recruited through mental health clinics and community organizations. Thematic analysis was conducted on the transcripts to identify factors that support or hinder engagement with the platform.

RESULTS

Participants emphasized the importance of privacy, security, and personalization in building trust in the platform, with 72% reporting that clear communication about data protection would increase their likelihood of use. Progress tracking features, such as symptom trend visualizations and diaries, were identified by 65% of participants as critical for sustaining engagement. Ease of use was highlighted, with 58% preferring mobile app functionality over web-based interfaces. Dynamic content and personalized notifications were suggested as strategies to maintain long-term use, with 64% of participants valuing customizable reminders to encourage daily interactions. Rural participants (41%) noted the need for offline functionality due to inconsistent internet access. Additionally, participants recommended features such as crisis support, professional communication channels, and access to local mental health resources.

CONCLUSIONS

Youth-centered design is essential for enhancing the usability and engagement of dMH platforms like Innowell. Key features prioritized by participants included privacy, security, progress tracking, and personalization. Dynamic and user-friendly interfaces, along with the ability to customize notifications and access professional support, were critical for fostering long-term engagement. Insights from this study provide actionable recommendations for optimizing dMH platforms to meet the mental health needs of young people, particularly in diverse urban and rural settings. Future research should explore implementation strategies tailored to specific user demographics to enhance the scalability and impact of dMH interventions.
Rainwater Harvesting for Drought Disaster Prevention in Seraya Village, Karangasem Regency, Bali Province, Indonesia
Authors: Ardana Putu Doddy Heka , Pamungkas Tri Hayatining , Putra I Gede Adi Alit
Published: January 2025

Drought is a recurring disaster in several regions of Indonesia, often happening from April to September annually. During the dry season, a substantial reduction in rainfall leads to inadequate water supplies and drought. Drought significantly affects food crop output, water scarcity, and reduced water availability for daily necessities, disrupting everyday activities like bathing, washing, and cooking. Seraya Village, situated in Karangasem Regency, Bali Province, frequently faces drought conditions. Seraya, a settlement prone to drought, was officially designated as such by the Karangsem Regent by Regulation Number 36 of 2008, specifying the location of drought natural disasters in Seraya settlement, East Seraya, and West Seraya in the Karangasem District. This study aimed to compare the capacity of rainwater harvesting with the current home water demand in Seraya-Karangasem Village to determine the feasibility of using rainwater to address water shortages and avert drought. This study employs quantitative descriptive methods by analyzing primary data on the regional conditions and limits of the study area, along with secondary data on demographic (population), geographical, and rainfall data spanning a decade. The study revealed that the rainwater harvesting potential in Seraya Village, Karangasem District, was 254342191.15 liters per year, while the total water demand was 227660565 liters yearly. This resulted in excess harvested water amounting to 26681626.15 liters per year, 12% more than the total water needs. The excess amount of rainwater that may be harvested compared to the entire domestic water demand demonstrates the effective utilization of rainwater harvesting systems in preventing water shortages and droughts in Seraya-Karangasem Village.
Seismic and Tsunamis Vulnerability Assessment of the Shelter School Building Structure with and without Retrofitting
Authors: Fauzan  , Zev Al Jauhari  , Geby Aryo Agista  , Yokota Atsushi , Masharya Eko Putra
Published: January 2025

Understanding the vulnerability of school shelters to tsunamis is crucial for developing effective mitigation strategies and increasing the resilience of coastal communities in the education sector. SDN 02 Sasak Ranah Pasisia, an elementary school in West Pasaman Regency, West Sumatera, Indonesia, had a shelter building constructed in 2010. However, the construction remains incomplete. A structural assessment using current Indonesian building codes and vulnerability analysis is necessary to proceed with construction and ensure the building’s strength against the working loads. Thestructural assessment revealed that several columns could not support the working load, necessitating local retrofitting. In this study, the retrofitting of the building was designed using concrete jacketing. Furthermore, structural fragility curves of the school building were developed before and after retrofitting against earthquake and tsunami loads. The seismic fragility curve was determined from the maximum displacement of the building for varied earthquake acceleration, using nonlinear time history dynamic response analysis scaled using the incremental dynamic analysis method and damage limits defined by ATC-40, characterized by Hazus. Meanwhile, the tsunami fragility curve was determined from the maximum displacement due to tsunami load for each variation of tsunami inundation depth. The vulnerability analysis results indicated that retrofitting the school building with concrete jacketing reduces the probability of building damage due to earthquake loads by 18% at the level of complete damage at a PGA of 0.520 g (based on the Indonesian Seismic Map). Similarly, it reduced the probability of building damage due to tsunami loads by 20%, at the level of complete damage corresponding to a tsunami wave height of 5.00 m for West Pasaman, Indonesia.
A produção científica sobre a regulação de medicamentos sem registro no Brasil, nos Estados Unidos e na Europa
Authors: Dos Santos Teles Cardoso Amanda , Alves Costa Ediná
Published: January 2025

Introduction: The use of unregistered drugs indicates a shift in the regulatory paradigm for innovative medicines by shortening access to drugs that are still in the experimental phase, which also increases uncertainties regarding the risks associated with their use. Objective: to identify the characteristics of scientific publications on the regulation of unregistered drugs in Brazil, the United States, and Europe. Method: This is a descriptive, quantitative study involving bibliometric analysis. A total of 58 studies were selected based on the descriptors and eligibility criteria from the SciELO, Portal Capes, and Web of Science databases. Absolute and relative frequency analyses, as well as averages of the categories listed in the analysis plan, and keyword profiles using VOSviewer® were performed. Results: Researchers’ interest in this topic has been growing since 2016. Academic production was concentrated in the United States, with original articles having low methodological rigor, and focused on medical journals. Some studies declared conflicts of interest with the pharmaceutical industry. The central themes were  “aspects of the regulatory framework for expanded access/compassionate use” and “ethics in the use of unregistered drugs,” with the main keywords being: expanded access, efficacy, safety, Covid-19, risk, emergency authorization, and real-world data.  Conclusions: The regulation of unregistered drugs deserves further exploration through high-quality studies in the field of Public Health, particularly in  countries of the global south, with research that focuses on building elements of individual and collective health protection in the regulation of unregistered drugs.
Solubility and Dissolution Enhancement of Poorly Soluble Drug Aripiprazole through Solid Dispersion
Authors: Y Anand Kumar  , Srivatsa Sangawar
Published: January 2025

Aripiprazole (ARP) having lowest water solubility indicates class II drugs of BCS. These classes of drugs could potentially exhibit dissolution rate limited absorption. The objective of the present study is to improve the solubility and dissolution of Aripiprazole through solid dispersion (SD) technique. ARP-SDs were prepared by Kneading (KNE), Solvent evaporation (SE), Melt solvent (MS) and Microwave irradiation (MW) methods using PEG 4000, PEG 6000 at 1:1, 1:4 ratios. ARP-SDs were studied in solution state by solubility, in vitro dissolution rate and solid state by FTIR, XRD, and relative dissolution parameters through PCP Disso V3 software. The FTIR studies indicate no interaction in all the ARP-SDs, the powder XRD studies indicate lot of decrement in the principle peak heights of ARP in ARP-SDs suggest the transformation of crystalline ARP into nearer amorphous state predicting micronization mechanism. The solubility was improved linearly with increase in concentrations PEG 4000 and PEG 6000. The amount of ARP release from ARP-SDs prepared by KNE were found to be greater than other ARP-SDs and was in the order KNE>SE>MS >MW >PM>ARP. The dissolution of ARP-SDS, obeyed first order kinetics and model fitted with Hixon crowel. One-way ANOVA results suggest the DP60, and DE60 values were significantly higher (P<0.01) in ARP-SDS than pure drug. The result concludes that solid dispersion technique was can be used increase the solubility and dissolution of poorly soluble drug Aripiprazole.
Solid Lipid Nanoparticles as Novel Carriers for Enhancing Classical Antifungal Therapies
Authors: Sadule Akshay S  , Dr. Sameer Shafi  , Komal Jadhav  , Vijay Shinde  , Punam Londhe
Published: January 2025

Fungi are increasingly recognized as significant human pathogens, making effective diagnosis and treatment crucial. While the introduction of new antifungal agents over the past two decades has advanced treatment options, rising drug resistance presents a challenge. Nanoparticles (NPs) have emerged as a promising solution for delivering antifungal drugs, offering greater inhibitory effects at lower concentrations compared to traditional antibiotics. Key issues such as reduced efficacy, limited tissue penetration, poor solubility, and decreased bioavailability often hinder antifungal treatments. Incorporating antifungal drugs into various NP delivery systems aims to overcome these limitations. This review discusses different types of NPs used for antifungal delivery and highlights their advantages over conventional drugs.
The trends of tourism sector after COVID-19 period: A study of strategy and implications
Authors: Efthimiou Stavros G.
Published: January 2025

In recent years, international economic growth has been slow. The influence of the COVID-19 pandemic on the world’s economies must be considered. COVID-19 is not only a risk to the public health sector, but it is also a serious threat to the entire global economy. The paper examines the diversification of tourism industry trends and volumes as a result of the COVID-19 pandemic. Furthermore, the paper presents the tourism industry’s contribution to economic development, as well as its levels and trends before, during, and after the period of COVID-19 pandemic, along with predictions for the future transformation of tourism trends (International Monetary Fund [IMF], 2021; Organisation for Economic Co-operation and Development [OECD], 2022). The main contribution of this paper to the existing literature is the addition of new and more relevant views about COVID-19 and the tourism sector around the world by a comparative bibliographic review with a presentation of data on tourism and economic development and how COVID-19 affected the sector, the new normality of tourism, in order that tourism is a complex and very dynamic factor in the economic cycle of each country, at the same time to its influence on the social stability of each country as a whole.
„Sloga, sloga i ništa drugo nego sloga”
Authors: Leček Suzana
Published: January 2025

U članku je istražen problem unutarstranačke demokracije u Hrvatskoj seljačkoj stranci nakon Šestosiječanjske diktature. U uvjetima pravne nesigurnosti, u kojima se rad stranaka tolerirao, ali nije legaliziran, Hrvatska seljačka stranka ne obnavlja sva stranačka tijela. Analizirano je na koje načine stranka kompenzira taj strukturni nedostatak (konzultacije, simbolička podrška, disciplina) te kako koristi pridružene organizacije (Gospodarska sloga, Seljačka sloga) i položaje u samoupravnim tijelima (općina, Banovina Hrvatska) da bi razvijala stvarnu demokraciju.
Hrvatske postrojbe u Desetoj sočanskoj bitci 1917. godine
Authors: Tominac Nikola
Published: January 2025

Na temelju raspoložive literature i izvorne arhivske građe iz fundusa Austrijskoga državnog arhiva autor obrađuje 10. sočansku bitku, i to borbe na Banjškoj planoti, prvenstveno za greben od samostana Svete Gore do kote 383 kod sela Plave, gdje su se brutalno sukobile talijanske i austrougarske snage. Tu su znatno sudjelovale postrojbe s današnjega područja Hrvatske, Slovenije te Bosne i Hercegovine.
Nano simply alpha open set and novel neighborhood techniques for accurate symptom detection in medical applications
Authors: El Sayed
Published: January 2025

This study introduces the nano simply alpha open set and proposes a new
approximation space extending Pawlak?s approximation. This new space
includes the nano simply alpha lower and nano simply alpha upper
approximations, denoted by specific notations, offering a refined framework
for analyzing data. The ? n?-lower and ? n?-upper approximations for any set
Also, we study nano ? n?-rough approximation. Those investigations look at
the connections between various approximation types and their
characteristics, proposing methods applicable to medical diagnosis and other
decision-making fields. These methods provide deeper data insights,
enhancing precision and reliability in complex problem-solving. We
introduce a ?general neighborhood? concept, expanding on Pawlak space with
a general upper and lower approximation. A case study for chronic kidney
disease demonstrates the effectiveness of these methods in identifying
critical symptoms. Additionally, an algorithm a, supports application for
any number of patients or decision-making issues.
Quantum battery systems: Analyzing two-mode field charging, qubit interactions, and environmental influences
Authors: Zahia Ahmed , Abd-Rabbou Mahmoud , Khalild Eied , Al-Awfi Saud
Published: January 2025

This study investigates the dynamical behaviour of a two-cell (two-atom)
quantum battery driven by a two-mode charging field. We explore the
influence of varying interaction strengths on the system?s performance. This
includes increasing the coupling between cells and charging fields, and
cells themselves through a dipole interaction and Ising interaction along
the z-axis. Additionally, the impact of environmental effects is examined by
incorporating decay terms for both the charging fields and the cells. Our
analysis focuses on key performance metrics such as stored energy, average
power, ergotropy, energy fluctuations, and quantum speed limit time. The
results reveal that the environment negatively impacts stored energy, power,
and ergotropy, but leads to higher speed limits. Enhanced coupling between
the charging fields and the cells improves the studied correlations,
promoting efficient energy transfer and decreasing speed limit time.
Increasing the coupling between the cells, either via the dipole or Ising
interaction, generally exhibits a similar effect. This involves a decrease
in maximum achievable energy storage, accompanied by the emergence of more
erratic energy fluctuations.
The security of text data based on cyclic codes over algebraic structure
Authors: Bahaddad Adel , Asif Muhammad , Ashraf Usman , Asiri Yousef , Alkhalaf Salem
Published: January 2025

The demand for network security is increasing exponentially as businesses
strive to protect personal data from theft or loss. Data security is a
paramount concern for both individuals and organizations engaged in various
forms of communication, particularly in cyberspace due to the rise of
digital computing and communication. With the rapid advancement in digital
data exchange, securing information during transmission and storage has
become increasingly critical. Given the extensive use of text in security
agencies and industries, it is crucial to protect confidential text data
from unauthorized access. This paper proposes the use of Bose Chaudhary
Hochquenghem (BCH) codes over the Galois field in a modified advanced
encryption standard (AES) algorithm to secure text data. Secret keys are
generated using the generator polynomial of BCH codes over the Galois field,
which is also applied to construct maximum distance separable (MDS)
matrices. The proposed scheme enhances the mixed column operation and
sub-key construction steps of the AES algorithm using BCH codes over the
Galois field. The secret key, based on the designed distance of BCH codes,
is difficult to predict using exhaustive key search methods. The avalanche
effect test, involving single-bit changes in plaintext and secret keys,
along with the popular national institute of standards and technology (NIST)
test, confirms that the proposed scheme improves ciphertext encryption.
Security analysis results demonstrate better encryption performance for
text data. In the future, this approach could be adapted for encrypting
images, audio, and video.
The normalized emission spectrum of the effective atom-photon-magnon system
Authors: Abu-Zinadah Hanaa , Khalil Eied
Published: January 2025

This paper explores the behaviour of the normalized emission spectrum within
the confines of the atom-photon-magnon regime at its dispersive limit, with
a focus on its dependency on various parameters and initial conditions. The
investigation reveals several significant findings. Firstly, regarding the
mixing angle and detuning, minimal variation in the spectrum is observed
with small detuning values, although the influence of the mixing angle
becomes more pronounced for the initial squeezed coherent and initial
binomial states, particularly notable in the case of the squeezed coherent
state. Secondly, concerning the initial state strength, an increase in
strength results in a gradual decrease in the spectrum across all states
except the binomial state, which finally experiences an increase. However,
the squeezed coherent state displays a gradual decay without reaching zero,
whereas the thermal state decays completely. Lastly, concerning
magnoncavity coupling, stronger coupling between magnon-and cavity causes
a shift in the spectrum towards higher positive detuning, with a more
pronounced shift observed in the squeezed coherent state compared to other
states.
Prediction of rock slope failure based on multiple machine learning algorithms
Authors: Mnzool Mohammed
Published: January 2025

Slope failures have the potential to seriously jeopardize access to
sustainable development since they cause numerous casualties as well as
disastrous effects on society and the economy. It is imperative to use
precise operable computational designs in this case. This study examined
the efficacy of five distinct machine learning models, namely support vector
machines, decision trees, gradient boost machine learning, and random
forest, in predicting the slope safety factors. This article?s primary goal
is to assess and improve the different machine learning-based analytical
representations in relation factor of safety computations. The genetic
algorithm mimics the processes of growth, hybridization, and mutagenesis
found in the expected collection and inherent procedures to resolve the
hyperparameters of machine learning algorithms. A total of 217 cases were
collected in order to train and evaluate these models. Multiple convergence
analysis is also used to study the independence of individual
characteristics. The assessed methods? competence was assessed through the
application of diverse performance assessment indicators. The various
classifiers function satisfactorily for slope failure inquiry, according to
the evaluation and comparison of the data. Random forest was found to be the
best classification method for slope failure prediction, with an accuracy of
91%.
Generalized hyperbolic function space of mixed norms with some applications
Authors: Abdalla Mukhtar
Published: January 2025

This paper presents new definitions for Bloch spaces, hyperbolic derivatives,
and general hyperbolic Besov spaces. Furthermore, we present a fresh
demonstration of the hyperbolic function through the application of Holder
inequality. Through the application of Holder inequality. We also provide
attributes for functions within the declared classes in the unit disc.
Furthermore, a collection of weighted tent functions is studied, and
features of identity operators are investigated for the new tent function
spaces.