bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Acquisition Factor and Satisfaction of Alternative Real Estate after Land Expropriation
Authors:   Residential Environment Institute Of Korea, Park Sung Moo , Kang Jung Gyu
Published: September 2022

The state expropriates private land to meet the demand for realization of the public interest, and individuals want to be compensated in a fair price if they cannot refuse to take land for a state-led development project. Many previous studies have been conducted on the topic of resolving conflicts and confrontations between land expropriators and prisoners, and accordingly, various solutions such as improvement of laws and systems have been suggested. However, conflicts and confrontations over fair compensation for land expropriation have not completely disappeared from our society, and efforts to amicably resolve them are continuing. The research results obtained through this study showed that 'investment' was the most common purpose at the time of initial acquisition of expropriated land, and the period of holding it for 3~5 years was the most. 'Land' was the most common type of real estate acquired by substitution, followed by 'Land + Building'. 'About 70%' had the highest percentage of using the compensation amount as an alternative acquisition. The reasons for replacing accommodation compensation with real estate were 'tax benefits' and 'high future value'. The biggest obstacle to the acquisition of alternative real estate is that the land price rises significantly as speculators purchase land near the land compensation area for profit. Then, the damage is passed on to the replacement buyer, and the government needs to block such speculative demand in advance. In addition, if a landowner receives land compensation and pays capital gains tax, the remaining land compensation amount cannot be replaced with land of the same size or value as the existing ownership. Therefore, it is necessary to further expand the reduction in capital gains tax to the acquirers of alternative real estate, and an improvement plan is needed for a wide range of 'recognition of the total amount of compensation for expropriation of the expropriated land'.
Analyzing the Classification and Characteristics of Regional Types according to the Balanced National Development Index
Authors:   Residential Environment Institute Of Korea, Kim Sung Rok
Published: September 2022

This study is significant in that it provides basic data for enforcing relevant policy by classifying basic local governments across the country into types according to the Balanced National Development Index.
The analysis results reveal that, out of the 229 analysis target areas, 62 centering on Si(city) were classified as cluster 1, 73 centering on GU(borough) were classified as cluster 2, and 94 areas centering on GUN(county) were classified as cluster 3. A look into characteristics depending on regional type shows how cluster 1 demonstrated relatively more positive outcomes than clusters 2 and 3 in terms of ‘changing trends within the period’ such as rate of change in population and rate of change in the number of businesses. Next, cluster 2 indicated more positive outcomes than clusters 1 and 3 in terms of ‘facility access’, such as the percentage of infants and young children within daycare center service areas, the percentage of school-aged children within elementary school service areas, and the population percentage within library service areas. Cluster 3 exhibited a high level of outcomes in indices based on population numbers, such as the number of schools per 1,000 students and the number of cultural infrastructure facilities per 10,000 population. As cluster 3 centers on gun areas, these outcomes paradoxically assume the realities of local extinction as a result of population decreases in gun areas.
The association between iron deficiency anemia and obesity in children
Authors: Atrushi Akrem M. , Armishty Farhad , Saleh Sirwan A. , Abdulrahman Mehvan Sh.
Published: September 2022

Objectives: To examine the association between obesity and iron status and the presence of iron deficiency anemia in children.
Methods: This case-control study included 100 children between 2-14 years of age who were divided into two age- and sex- matched equal groups of 50 children each. Children with a body mass index (BMI) greater than or equal to 95th centile were categorized as obese while the other 50 children with a BMI greater than or equal to 5th centile but less than 95th centile were considered the normal weight group. Children with cardiac disease, liver disease, chronic gastrointestinal disease and chronic hematologic disorders except iron deficiency (with or without anemia) and those taking Vitamin or mineral supplements regularly during the previous year were excluded.  Each participant was sent for serum iron, ferritin, total iron binding capacity (TIBC), transferrin saturation TS and complete blood count. Iron deficiency is defined as Transferrin Saturation (TS) lower than 16% and IDA is defined as TS lower than 16% and hemoglobin (Hb) concentration lower than 120 g/l or 12 mg/dl for children. The data were analyzed using SPSS-23 software and for all data normal distribution was tested so that P-value<0.05 is the level of threshold for statistical significance.
Results: The gender distribution between the both group is reversed with male being more common in obese group but no statistical difference. The age distribution shows dominance of the age group 5-10 years in the both group with some differences which are of no statistical significance (P=0.294). The values of Hemoglobin, serum iron, serum ferritin, total iron binding capacity and transferrin saturation are obviously similar between the both genders of the whole study population with no statistically significant differences (P=0.084, 0.469, 0.48,0.4, 0.571 respectively). Obese children have higher level of Hemoglobin(P=0.069), Ferritin(P=0.5) and total iron binding capacity(P=0.449) but lower levels of serum iron (P =0.234) and transferrin saturation(P=0.45) but with no statistical significance.
Conclusion: There is no significant association between obesity and iron status and the presence of iron deficiency anemia despite a lower level of serum iron and lower transferrin saturation in obese than normal weight children.
Effect of pollution represented by Polycyclic Aromatic Hydrocarbons on the levels of p53 and some antioxidant enzymes in Baghdad traffic police
Authors: R. Salem Ashraf , A.R. Al-Wasiti Estabraq , A. Hasan Fahem
Published: September 2022

Objectives: To ascertain the protective effect of p53 tumor protein by monitoring its levels in comparison with the levels of antioxidant enzymes, against any type of cancer that can be caused by chronic exposure of traffic policemen to air pollutants.

Methods: This study comprises 140 participants, who have been divided into two groups (Traffic police and Office police). PAHs were analyzed for each participant by GC/FID while p53 protein and antioxidant enzymes were measured by the ELISA technique. 

Results: The concentrations of polycyclic aromatic hydrocarbons and p53 tumor protein were high in the blood of traffic police compared to office police, while higher levels of antioxidant enzymes (Catalase and G-Px) were observed in the blood of office police.

Conclusion: Exposure to PAHs can cause oxidative stress, which can damage DNA and lead to cancer. However, because natural endogenous biomolecules like p53 protein can neutralize PAHs' carcinogenic effects, their elevation has a beneficial anti-cancer effect by reducing oxidative stress and preventing tumorigenesis.
Relationship of Midkine in Myocardial Infarction patients and some biochemical parameters
Authors: Abdlkhaliq Abass Alkado Obeda , Abd Ali Al-Helaly Luay
Published: September 2022

Objectives: This study aims to estimate the concentrations of MK, hs-CRP, TnI, AST, ALT and ALP in serum for MI in comparison to wholesome controls, in an effort to check the quantity of this impact at the pathological condition, in addition to understanding the position of MK in MI sufferers and its relationship to liver function tests and may be used as biochemical markers to decide the severity of MI in sufferers.

Methods: The studying include the investigation of midkine (MK), High-sensitivity C-reactive protein (hs-CRP), Troponin I (TnI), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels in myocardial infarction (MI) patients. The study includes (84) samples: 34 of myocardial infarction patients (19 male and 15 female) and 50 sample of apparently healthy as control group (25 male and 25 female). Samples were collected during the period from Jan. 2021 to July 2021 from in-patients of Cardiac Surgery Center admitted at Ibn Sina Teaching Hospital and Mosul General Hospital, Mosul, Iraq with matching age ranged between 26-86 years. The clinical diagnosis in each case is made according to a cardiovascular specialist.

Results: The results showed that there was a significant increase in MK, TnI, GOT, GPT and ALP for all studied groups (males and females) of MI patients compared with control groups, and there was no any a significant in hs-CRP. Beside of, showed significant positive correlation between MK with BMI, hs-CRP, TnI, AST, ALT and ALP in control and patients group. Whereas there were no any correlation between MK with age, in patients and control under study.

Conclusion: The study indicated that the MK increased in patients with myocardial infarction, and it’s increased in males more than female patients, and that may act as a good markers for diagnosis of myocardial infarction disease.
Lógica bélica y régimen de verdad. Análisis crítico de la formación del discurso jurídico penal de intervención máxima en la sociedad costarricense
Authors: Morales-Jiménez Juan Carlos
Published: September 2022

Escudriñar cuáles son los principales factores y estrategias que guían la construcción discursiva en el ámbito penal dentro del contexto de la sociedad costarricense actual, mediante la utilización cualitativa, correlacional y exploratoria de un instrumental crítico basado principalmente en la etnometodología y el socioconstruccionismo y nutrido por los insumos que ofrecen Michel Foucault y diferentes autores, permite establecer que la lógica bélica está ejerciendo una influencia definitoria en la formación del discurso jurídico penal y en la consecuente construcción del régimen de verdad en el entorno nacional; por lo que, con la intención de sentar algunas bases para fomentar un cambio de paradigma, en este artículo se realiza un examen general de aspectos como la noción de guerra permanente que se yergue en el imaginario colectivo gracias a la influencia de los centros de ejercicio de poder, el valor de los dispositivos discursivos legales como una herramienta para la dicotomización social y la perpetuación del poder, la relación orbicular entre el discurso, la verdad y el poder para la producción de efectos en el ámbito penal, así como de la utilización del miedo colectivo y de la intolerancia discursiva como elementos inherentes a la noción prioritariamente guerrera que se le está otorgando al discurso jurídico penal en Costa Rica.
La imagen que se crea sobre el artista y el medio que lo rodea, un estudio de caso de la película "El Comediante" de Gabriel Nuncio y Rodrigo Guardiola
Authors: García Macías Omar
Published: September 2022

En el presente trabajo, se pretende estudiar a partir de las ideas de arte y el concepto de artista según Emmanuel Kant y Pierre Bourdieu, cómo es que la sociedad formula y encadena a las personas que buscan en el arte su forma de expresión y su deseo de vida. Lo anterior abordando como caso de estudio la película El comediante, dirigida por Nuncio y Guardiola (2021).
Sexual imprinting leads to speciation in locally adapted populations
Authors: Sibly Richard , Curnow Robert
Published: September 2022

Sexual imprinting is widespread in birds and other species but its
existence requires explanation. Here we show that sexual imprinting
leads to speciation in locally-adapted populations if a neutral mating
cue – e.g., novel plumage coloration – arises through mutation. Local
adaptations occur when evolution results in stable genetic polymorphisms
with one allele predominating in some areas while others predominate
elsewhere. Here we use a deterministic two-niche population genetic
model to map the set of migration and selection rates for which
polymorphic evolutionary outcomes, i.e., local adaptations, can occur.
Equations for the boundaries of the set of polymorphic evolutionary
outcomes were derived by (Bulmer, 1972), but our results, obtained by
deterministic simulation of the evolutionary process, show that one of
Bulmer’s equations is inaccurate except when the level of dominance is
0.5, and fails if one of the alleles is dominant. Having an accurate map
of the set of migration and selection rates for which polymorphic
evolutionary outcomes can occur, we then show using the model of (Sibly
et al., 2019) that local adaptation in all cases leads to speciation if
a new neutral mating cue arises by mutation. We finish by considering
how genome sequencing makes possible testing of our results.
Induction with prostaglandin and risk of uterine rupture in multiparous women: a national population-based cohort study
Authors: Ryberg Johanna , Carlsson Ylva , Thunström Erik , Svanvik Teresia
Published: September 2022

Objective To assess whether prostaglandin among multiparous women have
an increased risk of uterine rupture compared to primiparous and women
with one previous delivery. Design Retrospective observational
population-based cohort study. Setting All maternity wards in Sweden
Population Women that have undergone induction with prostaglandin
between May 1996 and December 2019, (n=59,019). Methods The study cohort
was obtained by using data from the Swedish Medical Birth Register,
which contains information from maternity and delivery records. Results
are presented as odds ratios with 95% confidence intervals. Main
Outcome Measures Uterine rupture Results Multiparous women without a
previous caesarean section giving birth after induction with
prostaglandins had an increased absolute risk (0.11%) of uterine
rupture compared to primiparous (0.03%) (crude OR 3.57; 95% Cl
1.49-8.59, p-value 0.004). Multiparous women without a previous
caesarean section had a lower absolute risk (0.04%) of uterine rupture
compared to women with a previous caesarean section (1.62%).
Multiparous women with one previous caesarean section, had a decreased
risk (0.83%) of uterine rupture compared to women with one previous
delivery with caesarean section (2.02%) (crude OR 0.4; 95% Cl
0.21-0.78, p-value 0.006). Conclusion Our study implies that multiparity
is a risk factor for uterine rupture when induced with prostaglandin in
women with no previous caesarean section and this should be taken into
account when deciding on the appropriate method of induction.
Busulfan Fludarabine and Melphalan is effective conditioning for pediatric and young adult patients with myeloid malignancies underdoing matched sibling or alternative donor transplantation
Authors: Katsanis Emmanuel , Truscott Laurel , Pariury Holly , Hanmod Santosh , Davini Monica , Maza Michelina de la , CPNP Lauren Sapp, MSN, , Staples Kyleigh , Proytcheva Maria
Published: September 2022

Background: Allogeneic hematopoietic cell transplantation
(allo-HCT) remains a curative option for patients with high-risk myeloid
malignancies. Procedure: We present our ten-year experience
(October 2012-October 2021) of consecutive allo-HCT in patients with
myeloid malignancies treated on the pediatric HCT service and
conditioned with myeloablative targeted dose-busulfan (BU), fludarabine
(FLU) and melphalan (MEL). Twenty-three children, adolescents, and young
adult patients (CAYA) (median age 15.4yr) with acute myeloid leukemia
(AML, n=17), myelodysplastic syndrome (MDS, n=4), or chronic myeloid
leukemia (CML, n=2) underwent allo-HCT post-BU-FLU-MEL. Four patients
had treatment-related AML/MDS. Donor/stem cell source was MSD PBSC
(n=7), MUD PBSC (n=2), UCB (n=3) or haploidentical-BMT (n=11). Risk
stratification was low (n=2), intermediate (n=15), high (=3) and very
high risk (n=1). The two patients with CML had failed tyrosine kinase
inhibitor therapies. Results: With a median follow-up of 39.6
months the relapse rate is only 4.5% with an OS 100%, PFS 95.5% and
graft-versus-host-free-relapse-free survival (GRFS) 67.8%. The donor
source and the GvHD prophylaxis regimen significantly impacted grades
II-IV aGvHD 66.7% versus 19.2% ( P=0.039) and cGvHD 66.7%
versus 0% ( P=0.002) in the patients receiving matched sibling
(MSD) or matched unrelated donor (MUD) PBSC compared to haplo-BMT
respectively, resulting in improved GRFS in haplo-BMT, 83.3% compared
to 40% matched donor PBSCT ( P=0.025). Conclusions: Our
results demonstrate that BU-FLU-MEL is efficacious conditioning for
disease control in young patients with myeloid malignancies undergoing
MSD or alternative donor allo-HCT but in the setting of PBSC grafts with
CSA-MTX GvHD prophylaxis it results in an unacceptably high incidence of
GvHD.
An Infrared Camera Array Calibration Method using Constant Temperature Heating Checkboard
Authors: Wu Tianhao , Zhang Yuxiang , Yang Jungang
Published: September 2022

Infrared camera array has been widely used in computer vision, remote
sensing and computational Imaging. Due to the lack of a infrared camera
array imaging model and a high-quality calibration object, high-quality
calibration of the intrinsic and extrinsic parameters of the infrared
array camera is a challenge. This letter proposes a calibration method
for Infrared camera array. Firstly, we propose an infrared camera array
imaging model which contains intrinsic, extrinsic and distortion
parameters of all sub-cameras of the infrared camera array. Then, we
propose an objective function for infrared camera array calibration and
use a non-linear algorithm to solve all parameters in infrared camera
array calibration model. To get stable infrared checkboard images, we
design a constant temperature heating checkboard. Experiment results
show our method can efficiently solve intrinsic, extrinsic and
distortion parameters with a low reprojection error and an excellent
refocusing performance.
Characterizing the Services of a Rehabilitation Centre Specialized in Spinal Cord Injury/Disorder using the International Classification of Service Organization in Rehabilitation 2.0 and Implications for Health Reporting: A Demonstration Project
Authors: Scheel-Sailer Anke , Selb Melissa , Baumberger Michael , Gemperli Armin , Eriks-Hoogland Inge , Jelmoni Luca , Metzger Stefan , Pannek Jürgen , Sigrist-Nix Diana , Stucki Gerold
Published: September 2022

Objectives: To characterize the services of a rehabilitation centre specialized in spinal cord injury/disorder (SCI/D) using the International Classification of Service Organization in Rehabilitation (ICSO-R) 2.0, and to evaluate its potential use in meeting health reporting and certification requirements.Methods: The post-acute and outpatient rehabilitation services at this specialized SCI/D centre were described, the SCI/D Framework of rehabilitation service type definitions considered, various rehabilitation centre stakeholders were consulted, and data were collected using the centre’s digital quality management system and institutional management tool. A structured internet search identified the national health reporting and certification systems relevant for SCI/D rehabilitation. The resulting systems were subsequently mapped with ICSO-R 2.0 categories.Results: ICSO-R 2.0 categories pertaining to the provider dimension were generally the same across the post-acute and outpatient services. ICSO-R 2.0 highlighted the nuances in service delivery between these 2 service types. Most of the categories could be mapped to at least 1 of the 10 health reporting and certification systems detected in the website search.Conclusion: ICSO-R 2.0 can be used to comprehensively describe the rehabilitation services of a specialized SCI/D centre in Switzerland. Despite some challenges, ISCO-R 2.0 has the potential to facilitate national health reporting and certification.
LAY ABSTRACTThe International Classification of Service Organization in Rehabilitation (ICSO-R) 2.0 has been developed to characterize rehabilitation services in different fields of rehabilitation. The aim of this study was to characterize different rehabilitation services in a centre specialized in spinal cord injury and disorder. Out of 9 rehabilitation services detected, post-acute and outpatient services were described. ICSO-R 2.0 highlighted the nuances in service delivery between these 2 service types. Most of the categories could be mapped to at least 1 of the 10 health reporting and certification systems detected in the website search. Despite some challenges, ISCO-R 2.0 has the potential to facilitate national health reporting and certification.
Potencial bioactivo de los residuos del cultivo de fresa (Fragaria x ananassa) en Costa Rica
Authors: Salas-Arias Karla Melissa , Salas-Morgan Bridget , Calvo-Castro Laura A.
Published: September 2022

El fruto de la fresa (Fragaria x ananassa) es un alimento ampliamente consumido a nivel mundial, y al cual se le han atribuido una amplia gama de propiedades beneficiosas para la salud humana, mayoritariamente asociadas a su potencial antioxidante. La búsqueda de fitoquímicos bioactivos en la fresa se ha enfocado en el fruto, mientras que el perfil bioquímico de las hojas ha sido poco estudiado y sigue siendo poco aprovechado, a pesar de constituir una fuente potencial de metabolitos bioactivos que podrían ser utilizados en la formulación de productos para el sector alimenticio, industrial y farmacéutico. Además, se ha reportado mayor contenido de polifenoles bioactivos en las hojas de fresa que en el fruto, y las hojas de fresa podrían ser una fuente importante de ácido elágico, un compuesto antioxidante bioactivo poco abundante en la dieta humana pero de gran potencial biomédico. Este artículo de revisión bibliográfica tiene como objetivo evaluar las características del cultivo de fresa (Fragaria x ananassa) en Costa Rica, con miras al aprovechamiento integral de los residuos agroindustriales de este cultivo. La información consultada demostró que la comercialización del cultivo de fresa se enfoca en el fruto, mientras que las hojas y el resto del material vegetativo de la planta se descartan periódicamente, y podrían ser incorporados en nuevas cadenas productivas. Este tipo de estrategias son de especial importancia para países pequeños en desarrollo y con economías de base agrícola, para mejorar el aprovechamiento de los residuos agroindustriales y darles un mayor valor agregado a los cultivos, en beneficio del ambiente y la salud humana.
Thyroglobulyn in Pleural Effusion in Metastasic Papillary Thyroid Cancer
Authors: Alvarez Castillo Marlen Alejandra
Published: September 2022

We report case of massive pleural effusion caused by papillary thyroid cancer, which was accompanied by multiple pulmonary metastasis. A 60‑year‑old female patient presented with shortness of breath and cough due to massive left pleural fluid. Since cytological and cytochemical studies were not conclusive for the primary tumor, and the measurement of thyroglobulin washout has been recommended as a complementary study in suspicious cervical lymph nodes, we performed it using the cut- off points used in cervical lymph nodes.
Primary Hyperparathyroidism due to Ectopic Intrathymic Parathyroid Adenoma in A Child: A Case Report
Authors: Maali Ben Nasr
Published: September 2022

Primary hyperparathyroidism (PHPT) is a rare endocrine disorder in children and adolescents. Surgery is curative in most pediatric patients with PHPT. PHPT due to ectopic parathyroid adenoma (EPA) presents the difficulty of their exact topographic diagnosis and there is no consensus for the optimal imaging modality. The 99mTc-sestamibi (99mTechnetium -labeled methoxy-isobutyl-isonitrile) scintigraphy appears to be the best exam to establish a topographic diagnosis of parathyroid adenoma. Herein, we present the case of a 14-year-old girl with the diagnosis of PHPT with bone involvement. Parathyroid scintigraphy (dual-phase and dual tracer subtraction imaging), has shown an abnormal tracer uptake in the anterior mediastinum. Computed tomography (CT), has confirmed the mediastinal seat of the adenoma, measured 40 x 24.6 mm, repressing the thymus. An adenectomy was performed using video-assisted mini-thoracoscopic surgery. Histological findings have shown intrathymic ectopic parathyroid adenoma. After surgery, the patient had profound and persistent hypocalcemia as a result of extensive remineralization in a relation to Hungry Bone Syndrome (HBS). Through this clinical report, we insist on the importance of preoperative localization of parathyroid adenoma to select the surgical approach and to avoid failed cervicotomy especially in cases of ectopic adenomas.
An Update on the Risk Factors Correlating NAFLD with Cardiovascular Disease: Specifically Mitochondrial - Fatty Acids β Oxidation in Liver with Therapeutic Approaches of Avoidance of CVD Associated Mortality-A Systematic Review
Authors: Kochar Kaur Kulvinder
Published: September 2022

Nonalcoholic fatty liver disease (NAFLD) is a rapidly escalating disorder which impacts a large population worldwide. Nevertheless, cardiovascular disease (CVD) represents the biggest etiology for mortality with regards to patients of NAFLD. Atherogenic dyslipidemia, possessing the properties of plasma hypetriglyceridemia, enhancement of small dense (low density lipoproteins)LDL’s particles in addition to reduction of high density lipoproteins cholesterol HDL-C) concentrations are generally seen in patients with a presentation of NAFLD. Thus here we conducted a systematic review utilizing search engine PubMed, Google scholar ;web of science; embase; Cochrane review library utilizing the MeSH terms like NAFLD; CVD; atherosclerosis; insulin resistance(IR); NASH; chronic heart failure; dyslipidemia; hepatokines; endothelial impairment; pro inflammatory cytokines; FA’s oxidation; SREBP1c; ChREBP; Sirtuin; LKB1; lipogenesis; mitochondrial lipid β oxidation; genetic mutations from 2010 to 2022. We found a total of 500 articles out of which we selected 143 articles for this review. No meta-analysis was done. Thus here we have detailed the more recent genetic corroboration, with provision of distinctive type of metabolic pathways implicated in NAFLD pathogenesis. Assessment of the genetic results that are accessible pointed that the crucial process that correlated NAFLD modulated dyslipidemia, along with escalation of risk of CVD implied is the changes in the handling of fatty acids β oxidation in the liver mitochondria. NAFLD correlated genes possessing reported anti-atherosclerotic or cardio protective actions in addition to existent Pharmacologic approaches that are concentrated on tackling both treatment of NAFLD in addition to reducing the risk of CVD. Further research demonstrates that inhibitors of de novo’’ lipogenesis (DNL) might prove to be of benefit.
Glucocorticoid-Induced Growth Inhibition: An Update
Authors: I Goudochnikov Viktor
Published: September 2022

The mini-review is presented, including both early and recent investigations, on growth inhibition induced by glucocorticoids. These data are discussed, together with current concepts of growth regulation, involving tissue streaming and some evidence, as referred to stem and progenitor cells. It is outlined that future studies on cultures of induced pluripotent stem cells may open translational perspective for such area, important for endocrine aspects of pediatrics and perinatology
An Update on the Role of PI3K/ PTEN/ AKT Signaling Pathways in the Generation of Germ Cell Along with their Implications in Germ Cell Tumors Besides Ovarian Impairment: A Narrative Review
Authors: Kochar Kaur Kulvinder
Published: September 2022

Numerous studies have pointed that the PI3K/ PTEN/ AKT signaling pathways are the key controllers of generation of germ cells precursors labeled as Primordial germ cells in addition to sustenance of follicular pool. Earlier we have already highlighted the role of MAPK/ERK along with Hippo/MST signaling for escalating of effectiveness as well as avoidance of chemo resistance in various Cancer Therapies besides modes by which chemotherapy with utilization of alkylating Agents result in follicular activation if there was any further deletion of primordial follicles? along with use of manipulation of the signaling pathways inclusive of PI3K/Akt pathway along with Hippo signaling path way in the Yes-associated protein (YAP) transcriptional coactivator with post synaptic density protein, drosophila disc large tumor suppressor [PDZ] and zonula occludens-1-binding motif (TAZ) -besides other controlling constituents in the generation of the EFs correlated with development of Early/ Primordial Follicles for the escalated ART results in premature ovarian insufficiency (POI) & DOR patients. Here we concentrated on further updating the knowledge regarding germ cell tumors production besides reemphasizing on the dynamics of the ovarian Primordial germ cells pools besides decontrolling of these pathways In the generation of germ cell tumors along with ovarian impairment inclusive of, premature ovarian insufficiency (POI), premature ovarian failure (POF) & diminished ovarian reserve (DOR) patients. Thus here we conducted a review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms like germ cells origin; Primordial germ cells; PI3K/PTEN/AKT signaling pathways; Hippo/MST pathways; mammalian target of rapamycin complex (mTORC); eukaryotic translation initiation factor 4E binding protein 1( (4E-BP1) c; TAZ; YAP ; MST1/2. We searched from 1990’s till date in 2022 We found 150 articles of which we used 62 articles for this narrative review or updating the pathways implicated and detail these PI3K/ PTEN/AKT signaling pathways mainly from point of view of Primordial germ cells development besides germ cell tumors development.
Dinámica económica de las familias campesinas de las regiones de Huancavelica y Junín
Authors: Alzamora Norena Freddy Eutimio
Published: September 2022

Existe un problema latente en el sector agrícola en el cultivo de la papa ya que no siempre es rentable para los agricultores debido a que su precio de venta no solo depende de la cantidad de producto ofrecido en el mercado y de la demanda por parte de los consumidores sino, de la posibilidad de que ellos mismos realicen su comercialización. Este aspecto es analizado en esta investigación, cuyo objetivo se orientó a explicar los motivos por los que la comercialización de la papa afecta a la economía de las familias campesinas de las siguientes provincias: Tayacaja (Huancavelica) y, Huancayo (Junín). La investigación fue de tipo básico de nivel descriptivo-explicativo con diseño no experimental-longitudinal. La población estuvo conformada por 120 familias campesinas productoras y comercializadoras de papa de las provincias de Tayacaja y Huancayo de las que se extrajo una muestra de 91 familias. Para el trabajo de campo se utilizaron como instrumentos guías de análisis documental, fichas bibliográficas y un cuestionario. Se encontró a través de la aplicación de modelos econométricos que el 79% de los encuestados acepta que el precio de venta de la papa influye en la economía de las familias campesinas de las provincias en estudio dado que es muy bajo y no permite obtener ingresos económicos y que, la falta de almacenamiento de la papa a ser comercializada afecta la economía de las familias campesinas de estas provincias porque el producto se pierde y ello genera perjuicio económico.
Учение о любви-агапэ в трудах К.Льюиса
Authors: Рубцова Мария , Павенков Олег
Published: September 2022

В статью рассматриваются проблемы учения о любви-агапэ К.Льюиса как идейно-теоретических источников развития представлений агапэлогии. В данной статье мы рассмотрели вклад К.Льюиса к развитие агапэлогии как незавимой сферы знания. В работе подчёркивается необходимость создания агапэлогии как не только теоретической, но и практической сферы знания
Montados en la cultura de paz
Authors: Nava-Preciado José María
Published: September 2022

Este escrito presenta la sistematización de una experiencia de intervención con estudiantes de la Universidad de Guadalajara, México, en el marco del «Programa Integral de Cultura de Paz», a dos años de su implementación. Dicho programa se diseñó como estrategia de colaboración con el estudiantado para erradicar las violencias naturalizadas en este ámbito. Metodológicamente, la experiencia recupera las iniciativas y los conocimientos aplicados para enfrentarlas. Pese a la pandemia, la evaluación arroja ciertos logros; sin embargo, mientras los/as estudiantes no estén en las aulas, no contamos con evidencias sobre su efectividad.
“Educación técnica de la mujer”: el informe de Cecilia Grierson para Argentina y su recepción en Uruguay (1900-1918)
Authors: Clavero White Carolina
Published: September 2022

En el año 1899 la médica y profesora normal Cecilia Grierson fue encomendada por el gobierno argentino a estudiar todo lo relativo a la enseñanza de las mujeres en varios países de Europa. En 1902, presentó un informe donde exhibió el funcionamiento y los resultados de la enseñanza práctica ofrecida y finalizó con un análisis de la situación de este tipo de enseñanza en la República Argentina, las ventajas de su posible aplicación y los prejuicios que se debían combatir. El presente artículo sintetiza críticamente las ideas cardinales del informe de Cecilia Grierson y describe las relaciones entre los actores más relevantes identificados hasta este momento. Interesa demostrar que sus observaciones y argumentos fueron decisivos en Uruguay porque se constituyeron en fundamentos de las autoridades educativas y del sector gobernante para impulsar una política orientada a desarrollar la enseñanza de la economía doméstica. Se aborda el caso de la maestra valdense Ana Armand Ugon para exponer el carácter que tomó dicha orientación en Uruguay. También interesa aportar a un marco de discusiones académicas y políticas que buscan, en las experiencias del pasado, los cimientos que estructuraron las desigualdades sociales en los ámbitos domésticos, mercantiles y estatales.
El Departamento Nacional del Trabajo y las trabajadoras a domicilio
Authors: Bertolo Maricel
Published: September 2022

En este artículo se revisan las principales acciones impulsadas desde 1934 por el Departamento Nacional del Trabajo en relación al trabajo a domicilio, que antecedieron a la sanción de una nueva legislación en 1941. A partir del análisis de fuentes oficiales, se afirma que la agencia estatal desempeñó un rol activo frente a la problemática del trabajo a domicilio dentro de su esfera de competencia, en un sector laboral altamente feminizado. A su vez, este accionar promovió el desarrollo de negociaciones colectivas, en un contexto de creciente visibilidad y movilización de las costureras a domicilio.
La mentalidad del niño varón. La medición de las aptitudes en las primeras décadas del siglo XX en Buenos Aires
Authors: Benítez Sebastián Matías
Published: September 2022

El presente artículo tiene como objetivo analizar el conocimiento psicológico sobre los niños varones en las primeras décadas del siglo XX y su rol en la constitución de una idea específica de mentalidad masculina. Desde una perspectiva histórico-crítica, se analizan fuentes primarias que relacionan el ámbito de la psicología y la pedagogía en tópicos como la memoria, la atención, la imaginación y la medición del nivel intelectual. La recolección de datos psicológicos sobre los niños varones definió un tipo de masculinidad ligada al desarrollo de la razón y con posibilidades de trasformación del ámbito público, a partir de cierta estabilidad en el desarrollo de las aptitudes psicológicas. Ello sería consistente con los modelos de masculinidad hegemónica del momento, aunque pueden encontrarse algunas peculiaridades que complejizan esta caracterización.
Burton, Julia (2020). Desbordar el silencio, tejer complicidades. Acciones y voces del feminismo neuquino por el derecho al aborto. Temperley, Tren en Movimiento Ediciones, 220 págs.
Authors: Beliera Anabel Angélica
Published: September 2022

Revisión del libro Desbordar el silencio, tejer complicidades. Acciones y voces del feminismo neuquino por el derecho al aborto por J. Burton
Tossounian, Cecilia (2021). La joven moderna en la Argentina de entreguerras: Género, nación y cultura popular. Rosario, Prohistoria Ediciones, 174 págs.
Authors: Mezquita Juana
Published: September 2022

Revisión del libro La joven moderna en la Argentina de entreguerras: Género, nación y cultura popular por C. Tossounian
Right and left ventricular structures and functions in acute HFpEF: comparing the hypertensive pulmonary edema and worsening heart failure phenotypes
Authors: Iacovoni Attilio , Palmieri VIttorio , Abete Raffaele , Vecchi Andrea Lorenzo , Mortara Andrea , Gori Mauro , Tomasoni Daniela , De Ponti Roberto , Senni Michele
Published: September 2022

Background

Limited data are available on right (RV) and left (LV) ventricular structures and functions in acute heart failure with preserved ejection fraction (AHF-pEF) presenting with hypertensive pulmonary edema (APE) versus predominant peripheral edema (peHF).

Methods and Results

In a prospective study of consecutive patients with AHF-pEF, 80 patients met inclusion and not exclusion criteria, and underwent echocardiographic and laboratory examination in the emergency ward. The survived (94%) were re-evaluated at the discharge. At admission, systolic, diastolic, pulse blood pressure (BP), and high sensitivity troponin I were higher (all P < 0.05) with APE than with peHF while brain-type natriuretic peptide (BNP), hemoglobin and estimated glomerular filtration rate (eGFR) did not differ between the two phenotypes. LV volumes and EF were comparable between APE and peHF, but APE showed lower relative wall thickness (RWT), smaller left atrial (LA) volume, higher pulse pressure/stroke volume (PP/SV), and higher ratio between the peak velocities of the early diastolic waves sampled by traditional and tissue Doppler modality (mitral E/e′, all P < 0.05). Right ventricular and atrial (RA) areas were smaller, tricuspid anular plane systolic excursion (TAPSE) and estimated pulmonary artery peak systolic pressure (sPAP) were higher with APE than with peHF (all P < 0.05) while averaged degree of severity of tricuspid insufficiency was greater with peHF than with APE. At discharge, PP/SV, mitral E/e′, sPAP, RV sizes were reduced from admission in both phenotypes (all P < 0.05) and did not differ anymore between phenotypes, whereas LV EF and TAPSE did not show significant changes over time and treatments.

Conclusion

In AHF-pEF, at comparable BNP and LV EF, hypertensive APE showed eccentric LV geometry but smaller RV and RA sizes, and higher RV systolic function, increased LV ventricular filling and systemic arterial loads. AHF resolution abolished the differences in PP/SV and LV diastolic load between APE and peHF whereas APE remained associated with more eccentric RV and higher TAPSE.
Hierarchical Bayesian Model with Inequality Constraints for US County Estimates
Authors: Chen Lu , Nandram Balgobin , Cruze Nathan B.
Published: September 2022

In the production of US agricultural official statistics, certain inequality and benchmarking constraints must be satisfied. For example, available administrative data provide an accurate lower bound for the county-level estimates of planted acres, produced by the U.S. Department of Agriculture’s (USDA) National Agricultural statistics Services (NASS). In addition, the county-level estimates within a state need to add to the state-level estimates. A sub-area hierarchical Bayesian model with inequality constraints to produce county-level estimates that satisfy these important relationships is discussed, along with associated measures of uncertainty. This model combines the County Agricultural Production Survey (CAPS) data with administrative data. Inequality constraints add complexity to fitting the model and present a computational challenge to a full Bayesian approach. To evaluate the inclusion of these constraints, the models with and without inequality constraints were compared using 2014 corn planted acres estimates for three states. The performance of the model with inequality constraints illustrates the improvement of county-level estimates in accuracy and precision while preserving required relationships.
Small Domain Estimation of Census Coverage – A Case Study in Bayesian Analysis of Complex Survey Data
Authors: Elleouet Joane S. , Graham Patrick , Kondratev Nikolai , Morgan Abby K. , Green Rebecca M.
Published: September 2022

Many countries conduct a full census survey to report official population statistics. As no census survey ever achieves 100% response rate, a post-enumeration survey (PES) is usually conducted and analysed to assess census coverage and produce official population estimates by geographic area and demographic attributes. Considering the usually small size of PES, direct estimation at the desired level of disaggregation is not feasible. Design-based estimation with sampling weight adjustment is a commonly used method but is difficult to implement when survey nonresponse patterns cannot be fully documented and population benchmarks are not available. We overcome these limitations with a fully model-based Bayesian approach applied to the New Zealand PES. Although theory for the Bayesian treatment of complex surveys has been described, published applications of individual level Bayesian models for complex survey data remain scarce. We provide such an application through a case study of the 2018 census and PES surveys. We implement a multilevel model that accounts for the complex design of PES. We then illustrate how mixed posterior predictive checking and cross-validation can assist with model building and model selection. Finally, we discuss potential methodological improvements to the model and potential solutions to mitigate dependence between the two surveys.
Variable Inclusion Strategies through Directed Acyclic Graphs to adjust Health Surveys subject to Selection Bias for Producing National Estimates
Authors: Li Yan , Irimata Katherine E. , He Yulei , Parker Jennifer
Published: September 2022

Along with the rapid emergence of web surveys to address time-sensitive priority topics, various propensity score (PS)-based adjustment methods have been developed to improve population representativeness for nonprobability- or probability-sampled web surveys subject to selection bias. Conventional PS-based methods construct pseudo-weights for web samples using a higher-quality reference probability sample. The bias reduction, however, depends on the outcome and variables collected in both web and reference samples. A central issue is identifying variables for inclusion in PS-adjustment. In this article, directed acyclic graph (DAG), a common graphical tool for causal studies but largely under-utilized in survey research, is used to examine and elucidate how different types of variables in the causal pathways impact the performance of PS-adjustment. While past literature generally recommends including all variables, our research demonstrates that only certain types of variables are needed in PS-adjustment. Our research is illustrated by NCHS’ Research and Development Survey, a probability-sampled web survey with potential selection bias, PS-adjusted to the National Health Interview Survey, to estimate U.S. asthma prevalence. Findings in this article can be used by National Statistics Offices to design questionnaires with variables that improve web-samples’ population representativeness and to release more timely and accurate estimates for priority topics.
Application of foam separation in production of β-glucanase in Pichia
Authors: Yuhang Qin , Yuqing Chen , Yajuan Peng , Wenyao Shao
Published: September 2022

β-glucanase is widely used in many fields and has great economic value and development space, but it faces the difficulties of separation and nutrient destruction in the process of industrial production. Foam separation is a simple, mild and efficient adsorption separation technique that enables efficient separation and extraction of β-glucanase. In this study, five single factors (loading volume, pH, separation gas velocity, fermentation loading concentration, surfactant concentration) of foam separation and harvest of β-glucanase produced by Pichia pastoris were studied. The best univariate condition was: 600 mL/min separation gas velocity, loading volume of 200 mL, initial enzyme concentration of 100 g/mL, surfactant concentration of 0.3 mg/mL and pH of 5. Based on the best univariate condition, the optimal separation conditions of β-glucanase were further explored, and the five-factor four-level orthogonal test was designed. From the experimental results, the best separation condition was: 600 mL/min, loading volume of 200 mL, initial enzyme concentration of 100 μg/mL, surfactant concentration of 0.5 mg/mL and pH of 5. Under this separation condition, the enrichment ratio (E) was 0.56 and the recovery rate (R) was 96.01%.
Nathaniel Hawthorne’s Ecophilosophy in “Rappaccini’s Daughter”
Authors: Mnassar Sabri
Published: September 2022

This paper examines Nathaniel Hawthorne’s ecophilosophy in “Rappaccini’s Daughter” by focusing on his various representations of the natural environment and the human relationship to it. It suggests that the story reflects his belief that nature is divinely arranged and that humanity should protect rather than manipulate its systems. From his perspective, the disruption of natural systems would not only cause the extinction of many animal species but also endanger human life and existence on earth. The paper further suggests that Hawthorne promotes a view of nature as a living organism whose entities possess souls and spirits. Their capacity to have feelings and emotions makes them entitled to moral respect and consideration. In its study of the author’s environmental values and ethics, the essay claims that Hawthorne advocates the idea that human beings do not occupy a privileged position in the universe and that they are not superior or more important than nonhumans. In contrast to the Biblical vision of humankind, he portrays humans as weak and flawed creatures that cannot attain divine perfection. For these reasons, the paper asserts that “Rappaccini’s Daughter” exhibits Hawthorne’s deep ecological awareness and underlines his stature as a pioneer of American literary environmentalism.
Laughing with Beckett in Waiting for Godot and Endgame
Authors: Miyanrostaq Mohammad Masoodi , Mousavi Seyyed Mehdi
Published: September 2022

This paper examines the use of laughter as redemption in Samuel Beckett’s Waiting for Godot and Endgame. By acknowledging the somatic life of characters, Beckett’s humour problematises un-embodied philosophies of life. Challenging Hugh Kenner’s claim that Beckett’s humour is not redemptive because of the dryness and repetitions involved, it is argued that the foregrounding of fragility and vulnerability is a way of expressing deeply humane laughter in Waiting for Godot and Endgame. While highlighting that the dialectic of lack and excess is one source of Beckettian laughter, the main thrust of the argument emphasises the possibility of transcendence in a comic situation. The play of lack and excess, rather than suspending transcendental redemption, presents the human condition in its existential mundane realities. Accordingly, visceral and repetitive laughter are discussed in the two plays to bring to the fore the ironic and redemptive aspect of the comic, especially in the scenes where some sort of existential humour is implied.