bluuebunny/crossref_metadata_2025 huggingface dataset:
«АПТЕКА ЩАСТЯ» – БЛАГОДІЙНИЙ ЗАХІД ПРОФЕСІЙНОГО ТА МОРАЛЬНО-ЕТИЧНОГО СПРЯМУВАННЯ СТУДЕНТА-ФАРМАЦЕВТА
Authors: Fylypiuk O. M. , Nesteruk T. M. , Shtrimaitis O. V. , Sabadyshyn R. O.
Published: December 2019

У статті проаналізовано продуктивність роботи професійно-зорієнтованого благодійного заходу «АПТЕКА ЩАСТЯ» для формування професійної компетентності студентів спеціальності «Фармація».

Розробили методологію та принцип роботи «АПТЕКИ ЩАСТЯ» як професійно-зорієнтованої структури. Задекларували асортимент та анотації до «чудодійних» ліків. Залучили студентство до формування асортименту, пакування «чарівних пігулок», а пізніше і до їх реалізації. Вартість «цікавинок» не обмежувалася, всі кошти за реалізовані препарати збирали у спеціальні скриньки та були передані з благодійною метою.

«АПТЕКА ЩАСТЯ» – благодійний захід професійно-зорієнтованого спрямування. Має на меті сформувати стійкі моральні якості майбутнього фармацевтичного працівника: людяність, доброту, милосердя, відповідальність, порядність та доброчинність. Тому повномасштабне залучення студентів до проведення подібних виховних заходів формує соціально активні та творчі особистості, які поєднують у собі високі моральні й етичні принципи та професійну компетентність.
THE DEVELOPMENT OF MEDICINE AND HEALTH CARE IN PODILLIA IN THE XIX AT THE BEGINNING OF XX CENTURY
Authors: Sopiha M. O. , Mashtalir A. I.
Published: December 2019

The article is devoted to coverage of problems in medicine and health care in Podillia in 1793–1917 years. It is noted that in all corners of the Podillia region, the level of professional medicine in Podillia was extremely low. It was analyzed that in the vast majority of cases the medical aid was provided by charlatans and adventurers who shamelessly sold “miraculous medicines”, and the initiators of medical sanitation on Podillia were mostly city and city dwellers. The article also analyzes the achievements and contributions to the medicine of Podillia of such scholars as Yakiv Postolovskyi, Prokip Danilevskyi, Edmund Fahrenholz, Joseph Rollie, Mykola Pyrohov, Danylo Zabolotnyi, Ludwig Malinowski, Mykola Boliarskyi and others.
Lombo preto
Authors: Santana Joyce Maria Dos Reis
Published: December 2019

Poema
Nas Trilhas da memória
Authors: Santos Adelino Pereira dos , Ferreira Derneval Andrade
Published: December 2019

O objetivo deste trabalho é apresentar reflexões sobre o lugar da memória na construção da história da luta do povo angolano contra o colonialismo europeu, registrada simbolicamente nas narrativas dos romances  Mayombe, de Pepetela, e Noites de Vigília, de Boaventura Cardoso, considerando-se como pressupostos teóricos estudos da História Cultural e da Crítica Literária. Quando se toma o texto ficcional como base de estudos referente à memória, é preciso compreender as diversas vertentes que a literatura assume como instrumento de pesquisa. Nesse caso, o texto literário, dentre outras funções, pode assumir quase um lugar de memória, visto que o texto fictício apresenta certos aspectos que revolvem a memória, contribuindo assim para a ressignificação de papéis, um melhor entendimento cultural e também para reavaliar certas atividades e práticas sociais. Uma primeira versão deste texto foi apresentada como seção de capítulo da tese de doutorado em Estudos Étnicos e Africanos de um dos autores deste trabalho, defendida em 2016.
Corpos – fêmeos (in)visibilizados e socializados nas redes
Authors: ALVES CRISTIANE DE MESQUITA
Published: December 2019

Poesia - Corpos-fêmeos (in)visibilizados e socializados nas redes
Análise do conto “Impacto Poético”, de Luiz Silva, sob a ótica da experiência no Movimento Negro
Authors: Santos Anderson Caetano dos
Published: December 2019

Este trabalho toma o gênero conto como referência para estudar a produção narrativa de Cuti, Luiz Silva, escritor contemporâneo, que se dedica à temática afro-brasileira, à inserção do negro na sociedade brasileira, à experiência desse grupo, às suas vicissitudes, à dualidade entre aceitar a condição social imposta por anos de apagamento/silenciamento ou empreender a participação em movimento de resistência.
Bandeira Branca
Authors: Matos Zainne Lima
Published: December 2019

Poema
Novas perspectivas para o Comparatismo Literário de Língua Portuguesa
Authors: Inácio Emerson Da Cruz
Published: December 2019

A partir da discussão a reseito do Comparatismo Literário/ Literatura Comparada, apresento neste artigo algumas provocações para a leitura crítica da produção literária afroidescendente brasileira e portuguesa.
Entrevista com Lubi Prates
Authors: Bento Oluwa-Seyi Salles
Published: December 2019

Entrevista realizada com a poeta Lubi Prates, por email, em 16 de julho de 2019, em São Paulo.
A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction
Authors: Chen Si , Zhang Yishuai , Lighthouse Janet K. , Mickelsen Deanne M. , Wu Jiangbin , Yao Peng , Small Eric M. , Yan Chen
Published: December 2019

Background:

Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles of PDE10A in cardiovascular biology and disease are largely uncharacterized. The current study is aimed to investigate the regulation and function of PDE10A in cardiac cells and in the progression of cardiac remodeling and dysfunction.

Methods:

We used isolated adult mouse cardiac myocytes and fibroblasts, as well as preclinical mouse models of hypertrophy and heart failure. The PDE10A selective inhibitor TP-10, and global PDE10A knock out mice were used.

Results:

We found that PDE10A expression remains relatively low in normal and exercised heart tissues. However, PDE10A is significantly upregulated in mouse and human failing hearts. In vitro, PDE10A deficiency or inhibiting PDE10A with selective inhibitor TP-10, attenuated cardiac myocyte pathological hypertrophy induced by Angiotensin II, phenylephrine, and isoproterenol, but did not affect cardiac myocyte physiological hypertrophy induced by IGF-1 (insulin-like growth factor 1). TP-10 also reduced TGF-β (transforming growth factor-β)–stimulated cardiac fibroblast activation, proliferation, migration and extracellular matrix synthesis. TP-10 treatment elevated both cAMP and cGMP levels in cardiac myocytes and cardiac fibroblasts, consistent with PDE10A as a cAMP/cGMP dual-specific PDE. In vivo, global PDE10A deficiency significantly attenuated myocardial hypertrophy, cardiac fibrosis, and dysfunction induced by chronic pressure overload via transverse aorta constriction or chronic neurohormonal stimulation via Angiotensin II infusion. Importantly, we demonstrated that the pharmacological effect of TP-10 is specifically through PDE10A inhibition. In addition, TP-10 is able to reverse pre-established cardiac hypertrophy and dysfunction. RNA-Sequencing and bioinformatics analysis further identified a PDE10A-regualted transcriptome involved in cardiac hypertrophy, fibrosis, and cardiomyopathy.

Conclusions:

Taken together, our study elucidates a novel role for PDE10A in the regulation of pathological cardiac remodeling and development of heart failure. Given that PDE10A has been proven to be a safe drug target, PDE10A inhibition may represent a novel therapeutic strategy for preventing and treating cardiac diseases associated with cardiac remodeling.
Incidental Congestive Heart Failure in Patients With Aldosterone‐Producing Adenomas
Authors: Huang Wei‐Chieh , Chen Ying‐Ying , Lin Yen‐Hung , Chen Likwang , Lin Po‐Chih , Lin Yu‐Feng , Liu Yu‐Chun , Wu Che‐Hsiung , Chueh Jeff S. , Chu Tzong‐Shinn , Wu Kwan Dun , Huang Chun‐Yao , Wu Vin‐Cent , Lai Tai‐Shuan , Yang Shao‐Yu , Liu Kao‐Lang , Chang Chin‐Chen , Lee Bo‐Chiag , Wang Shuo‐Meng , Huang Kuo‐How , Lin Lian‐Yu , Liao Shih‐Cheng , Yen Ruoh‐Fang , Lu Ching‐Chu , Chan Chieh‐Kai , Er Leay‐Kiaw , Hu Ya‐Hui , Chang Chia‐Hui , Tsai Yao‐Chou , Ho Chen‐Hsun
Published: December 2019

Background

Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure (
CHF
). However, the effect of target treatment to the incidental
CHF
has not been elucidated. We aimed to investigate the risk of new‐onset
CHF
in patients with aldosterone‐producing adenomas (
APAs
) and explore the effect of adrenalectomy on new onset of
CHF
.

Methods and Results

From 1997 to 2009, 688
APA
were identified and matched with essential hypertension controls. The risks of developing incidental
CHF
(hazard ratio, 0.49; 95%
CI
, 0.31–0.75;
P
=0.001) and mortality (hazard ratio, 0.29; 95%
CI
, 0.20–0.44;
P
<0.001) were significantly lower in the
APA
group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of
CHF
(subdistribution hazard ratio, 0.55; 95%
CI
, 0.34–0.90;
P
=0.017) and mortality (adjusted hazard ratio, 0.27; 95%
CI
, 0.16–0.44;
P
<0.001) compared with essential hypertension controls.

Conclusions

In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental
CHF
and all‐cause mortality in a long‐term follow‐up.
miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart
Authors: Banavath Hemanth N. , Roman Barbara , Mackowski Nathan , Biswas Debjit , Afzal Junaid , Nomura Yohei , Solhjoo Soroosh , O'Rourke Brian , Kohr Mark , Murphy Elizabeth , Steenbergen Charles , Das Samarjit
Published: December 2019

Background

Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐
COX
1. miR‐181c/d
−/−
hearts experience less oxidative stress during ischemia/reperfusion (I/R) and are protected against I/R injury. Additionally, miR‐181c overexpression can increase mitochondrial matrix Ca
2+
([Ca
2+
]
m
), but the mechanism by which miR‐181c regulates [Ca
2+
]
m
is unknown.

Methods and Results

By
RNA
sequencing and analysis, here we show that hearts from miR‐181c/d
−/−
mice overexpress nuclear‐encoded Ca
2+
regulatory and metabolic pathway genes, suggesting that alterations in miR‐181c and mt‐
COX
1 perturb mitochondria‐to‐nucleus retrograde signaling and [Ca
2+
]
m
regulation. Quantitative polymerase chain reaction validation of transcription factors that are known to initiate retrograde signaling revealed significantly higher Sp1 (specificity protein) expression in the miR‐181c/d
−/−
hearts. Furthermore, an association of Sp1 with the promoter region of
MICU
1 was confirmed by chromatin immunoprecipitation‐quantitative polymerase chain reaction and higher expression of
MICU
1 was found in the miR‐181c/d
−/−
hearts. Conversely, downregulation of Sp1 by small interfering
RNA
decreased
MICU
1 expression in neonatal mouse ventricular myocytes. Changes in
PDH
activity provided evidence for a change in [Ca
2+
]
m
via the miR‐181c/
MICU
1 axis. Moreover, this mechanism was implicated in the pathology of I/R injury. When
MICU
1 was knocked down in the miR‐181c/d
−/−
heart by lentiviral expression of a short‐hairpin
RNA
against
MICU
1, cardioprotective effects against I/R injury were abrogated. Furthermore, using an in vitro I/R model in miR‐181c/d
−/−
neonatal mouse ventricular myocytes, we confirmed the contribution of both Sp1 and
MICU
1 in ischemic injury.

Conclusions

miR‐181c regulates mt‐
COX
1, which in turn regulates
MICU
1 expression through the Sp1‐mediated mitochondria‐to‐nucleus retrograde pathway. Loss of miR‐181c can protect the heart from I/R injury by modulating [Ca
2+
]
m
through the upregulation of
MICU
1.
Notes on the genus Zeravschania (Apiaceae) with description of two new species from Afghanistan and Iran

Authors: KLJUYKOV EUGENE , TERENTIEVA ELENA , UKRAINSKAJA ULIANA , LYSKOV DMITRY
Published: December 2019

Two species of Apiaceae are described as new to science: Zeravschania khorasanica from the Khorasan Province, eastern Iran, and Z. podlechii from the Ghor Province, central Afghanistan. Zeravschania khorasanica is related to Z. regeliana and Z. scabrifolia, but differs in rigid remains of petioles and sheaths, deeply laciniate ultimate segments of leaves, and broad-keeled ribs of mericarps. Zeravschania podlechii differs from other species of the genus in multiple stems, short internodes, dichotomous branching, and an unusual life form (сushion plant). In addition, Z. knappii is transferred to the genus Dichoropetalum on the basis of morphological evidence.
Crickets of the genus Gryllus in the United States (Orthoptera: Gryllidae: Gryllinae)
Authors: WEISSMAN DAVID B. , GRAY DAVID A.
Published: December 2019

Gryllus field and wood crickets of the United States, mostly west of the Mississippi River, are reviewed and revised. We validate the following 18 Gryllus cricket names: G. armatus, G. assimilis, G. brevicaudus, G. cayensis, G. cohni, G. firmus, G. fultoni, G. integer, G. lineaticeps, G. multipulsator, G. ovisopis, G. pennsylvanicus, G. personatus, G. rubens, G. texensis, G. veletis, G. vernalis, and G. vocalis. We synonymize G. alogus under G. vocalis. We designate a lectotype for G. armatus. We describe the following 17 new Gryllus species: G. chisosensis, G. leei, G. lightfooti, G. longicercus, G. makhosica, G. montis, G. navajo, G. planeta, G. regularis, G. saxatilis, G. sotol, G. staccato, G. thinos, G. transpecos, G. veintinueve, G. veletisoides, and G. vulcanus. We present biology, distribution, and genetic analysis of all taxa and discuss their nearest relatives.
2. Fifty Years of Innovation and Discovery
Authors: Windham Patrick , Van Atta Richard
Published: December 2019

Chapter 2, by Richard Van Atta, is a history of DARPA’s first fifty years.
3. NSF and DARPA as Models for Research Funding
Authors: Piore Michael J. , Colatat Phech , Beck Reynolds Elisabeth
Published: December 2019

Chapter 3, by Michael Piore, Phech Colatat and Elisabeth Beck Reynolds, compares DARPA’s culture with more traditional federal R&D agencies, including NSF.
8. DARPA’s Process for Creating New Programs
Authors: Cheney David W. , Van Atta Richard
Published: December 2019

Chapter 8, by David W. Cheney and Richard Van Atta, explores the processes through which DARPA creates new programs, looking at the origins of several past DARPA programs.
11. Program Management at DARPA
Authors: Jackel Larry
Published: December 2019

Chapter 11, by Larry Jackel, a former DARPA program manager, provides a perspective on the role of DARPA program managers in the DARPA model.
12. Lessons from DARPA for Innovating in Defense Legacy Sectors
Authors: Boone Bonvillian William
Published: December 2019

Chapter 12, by William B. Bonvillian, examines the lessons that DARPA’s model of creating innovation provides for other, older, “legacy sector” parts of the Department of Defense.
13. ARPA-E and DARPA
Authors: Boone Bonvillian William , Van Atta Richard
Published: December 2019

Chapter 13, by William B. Bonvillian and Richard Van Atta, discusses how leaders might effectively apply the DARPA model to the (then) relatively new Advanced Research Project Agency-Energy (ARPA-E) as well as organizational lessons from ARPA-E itself.
Moment Symmetry Models and Decompositions of Symmetry for Multi-way Contingency Tables
Authors: Yoshimoto Takuya , Tahata Kouji , Iki Kiyotaka , Tomizawa Sadao
Published: December 2019

For square contingency tables, Caussinus[ 1 ] demonstrated that the symmetry model holds if and only if both the quasi-symmetry and marginal homogeneity models hold. Bishop, Fienberg, and Holland[ 2 , p. 307] and Bhapkar and Darroch[ 3 ] provided similar theorems for multi-way tables. The present article proposes a moment symmetry model and unique decompositions of the symmetry model. For two-way tables, the second-order moment symmetry model decomposes the symmetry model into the second-order moment symmetry and marginal homogeneity models, while the [Formula: see text]th-order moment symmetry model decomposes the [Formula: see text]th-order marginal symmetry model using the [Formula: see text]th-order marginal symmetry model for multi-way tables.

AMS 2000 subject classification: 62H17
Re-examining Bartholomew's Index of Social Mobility: Some New Derivations with Statistical Inference
Authors: Chattopadhyay Nachiketa , Dewanji Anup , Roy Bimal K.
Published: December 2019

Based on Bartholomew's [1] index of social mobility, simple indices of directional, structural and exchange mobility over generations based on transition matrices are developed. Statistical inference on these measures are also presented along with an empirical illustration.
Book review: Anindita Chakrabarati, Faith and Social Movements: Religious Reform in Contemporary India
Authors: Chaudhury Sukant K.
Published: December 2019

Anindita Chakrabarati, Faith and Social Movements: Religious Reform in Contemporary India. Delhi: Cambridge University Press, 2018, 231 pp., Price not listed (hardback). ISBN: 978-93-86392-42-8.
Time constants for understanding building dynamics
Authors: Levermore Geoffrey
Published: December 2019

Building dynamics are key to summer overheating, plant sizing and ventilation strategies. Building designers need to consider the thermal mass of a building explicitly to understand fully a building’s response. Simulation programs readily show the dynamic responses but they are deduced from the solution of embedded intrinsic differential equations without simple understanding for initial design and appreciation. The admittance method gives such a simple understanding but the thermal mass effects are not obvious. Added to which the admittance is limited to a regular 24 h cycles of heat gains and losses. The Chartered Institution of Building Services Engineers (CIBSE) response factor is an approximation to the response of a building but it is limited to defining just slow or fast responses. Frequently, designers refer to heavyweight and lightweight buildings or even long and short time constants. The latter are simple and understandable. This paper explores the time constants and derives a simple multiple time constant equation to indicate thermal storage in a building. It is suggested that the simple time constant for building components is added to the data in the next edition of the CIBSE Guide A. This will aid designers in understanding a building’s winter heating and potential summer overheating and plant size implications.
Total Versus Completion Thyroidectomy: A Multidimensional Evaluation of Long-Term Vocal Alterations
Authors: Minni Antonio , Rosati Davide , Cavaliere Carlo , Ralli Massimo , Sementilli Giulio , Gallo Andrea , Brozzetti Stefania , Ossola Paolo , Cavallaro Giuseppe , Bononi Marco
Published: December 2019

Background:

Total thyroidectomy (TT) and completion thyroidectomy (CT) are two common surgical operations that are frequently followed by vocal symptoms despite preservation of the recurrent laryngeal nerve (RLN) and of the external branch of superior laryngeal nerve (EBSLN). The aim of this study was to analyze vocal alterations through endoscopic findings, videolaryngostroboscopy (VLS), acoustic vocal parameters and impact on patients’ quality of life after surgery in the absence of laryngeal nerve injury.

Methods:

We enrolled 198 patients who underwent thyroidectomy by the same surgeon. One hundred twenty-six patients underwent TT (group TT) while 72 underwent CT (group CT). All patients underwent preoperative VLS and Voice Handicap Index (VHI) assessment and postoperative VHI, VLS and Acoustic Voice Analysis with Multidimensional Voice Program Analysis 12 to 18 months after surgery.

Results:

We observed a statistically significant higher rate of EBSLN injury in CT compared to TT. Even in the absence of RLN and EBSLN injury, patients who underwent TT and CT presented slightly worse acoustic vocal parameters and VHI scores compared to healthy controls. Interestingly, some acoustic vocal parameters and VHI scores were significantly worse in group CT compared to group TT.

Conclusions:

The higher rate of EBSLN injury in CT rather than in TT suggests a higher surgical risk in CT. The vocal parameters of loudness and self-perception of voice were significantly worse after CT, suggesting a larger trauma in patients’ vocal outcome in CT if compared to TT, although these alterations were not reported as psychologically limiting daily life of patients. Nevertheless, the existence of multiple factors contributing to vocal alterations after thyroidectomy highlight the importance of a routine comprehensive functional voice analysis before and after surgery.
Modified graphene quantum dots-zinc oxide nanocomposites for photocatalytic degradation of organic dyes and commercial herbicide
Authors: Phophayu Suchada , Pimpang Pichitchai , Wongrerkdee Sawitree , Sujinnapram Supphadate , Wongrerkdee Sutthipoj
Published: December 2019

The high crystallinity of graphene quantum dots-ZnO nanocomposites is considered to have a significant effect in improving the carrier lifetime for enhanced photocatalytic degradation. The graphene quantum dots-ZnO nanocomposites were synthesized by adding graphene quantum dots solution into starting precursors during the precipitation. Characterization was performed using various techniques. High crystallinity of graphene quantum dots-ZnO nanocomposites is obtained in terms of increased crystal size and decreased dislocation density. The improved crystallinity increases the carrier lifetime on the material surface for the functional improvement of photocatalytic material. Photocatalytic test of methylene blue and methyl orange was performed under UV irradiation. Degradation rate constant reaches the maximum value for both organic dyes for the appropriate preparing condition of graphene quantum dots-ZnO nanocomposites. The graphene quantum dots-ZnO nanocomposites were then applied to degrade commercial glyphosate herbicide contaminants for an agricultural wastewater treatment investigation. The investigation aims to demonstrate a facile useful way of herbicide contaminant reduction for the better health of farmers. The graphene quantum dots-ZnO nanocomposites show an enhancement of the photocatalytic process with improved degradation rate constant (23% increased) in comparison to pure ZnO. Therefore, this work demonstrates that graphene quantum dots-ZnO nanocomposites can be used as a photocatalytic material for degrading organic dyes and commercial herbicide contaminants owing to its low-cost and environmental-friendly properties.
Preparation and properties of polyurethane coatings modified by polysilazane
Authors: Liu Xiaoli , Ge Zhen , Zhang Wenguo , Luo Yunjun
Published: December 2019

Due to their unique physicochemical properties, polysilazanes exhibit excellent performance when combined with some resin matrixes, which had drawn great research attention. In this article, polyurethane (PU) was firstly prepared by polytetrahydrofuran glycol, isophorone diisocyanate, and 1,4-butanediol as main materials. Then, the prepared PU was blended with polysilazane by mixing the two solutions together, which was cured to films via dip-coating method at room temperature. The structure, thermal stability, and surface properties of the composite coatings were investigated by Fourier-transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and X-ray photoelectron spectroscopy. The results demonstrated that after modification with polysilazane, the heat resistance, hydrophobicity, and mechanical property of the PU coatings were improved. When the content of polysilazane was 6 wt%, the mechanical property of the composite films was optimized, with a maximum tensile strength of 25.7 MPa and elongation at break of 797%. Meanwhile, the water contact angle of the composite film was 107° and the water absorption reached a minimum of 2.1%, which showed improved hydrophobicity and water resistance.
Investigation on surface roughness of piston in mini-magnetorheological damper using dissipative particle dynamics modeling
Authors: Ghafarian Eidgahi Moghadam Mohsen , Shahmardan Mohammad Mohsen , Norouzi Mahmood
Published: December 2019

Mini-magnetorheological damper is modeled using dissipative particle dynamics method, as a molecular modeling technique by applying various arrangement patterns of rough sections on the surface area of piston as four proposed scenarios of A, B, C, and D to obtain optimal damper performance. Modeling is developed to achieve 10-N damping force utilized in micro-machines and compared to experimental results that show good conformity. Weierstrass–Mandelbrot function is used to apply rough surface profile on the piston, and bounce back boundary condition is utilized as no-slip boundary condition. Results of modeling show that 140-CG magnetorheological fluid is suitable as the agent fluid. Also, it is observed that by increasing fractal dimension of roughness profile, damping force has an initial enhancement and then trends to a constant value. Results shown by utilizing Bouc–Wen model and genetic algorithm method and fractal dimension of roughness profile of 1.5 using at the beginning and the end of the piston as presented in scenario B; by applying 20% magnetic field strength, considered damping force of 10 N is achieved within 2 s, while under conventional conditions, using the smooth surface area of piston, more damping time is needed and more electrical energy is used than the developed model.
Radiological Evaluation of a Preoperative First Metatarsal Realignment Test for Metatarsus Primus Varus and Hallux Valgus Correction by the Syndesmosis Procedure
Authors: Wu Daniel Yiang , Lam Eddy Kwok Fai
Published: December 2019

Background:

Metatarsus primus varus correction is one of the primary surgical objectives for hallux valgus correction. Some soft tissue procedures have shown that the first metatarsal can be adequately realigned without osteotomy. The hypothesis of this study was that this correctability should also be demonstrable preoperatively. The purpose of this study was to assess whether a simple forefoot taping technique could do so and whether it could also be correlated with operative results after the syndesmosis procedure.

Methods:

Between May 2014 and December 2015, 147 feet with hallux valgus from 85 patients with an average age of 46.2 years underwent the syndesmosis procedure. All were followed prospectively with standing radiographic assessment of their first intermetatarsal angle, metatarsophalangeal angle, and medial sesamoid position preoperatively without and with a forefoot wrapping technique and postoperatively at 10 days, 6 months, and 1 year.

Results:

Their average preoperative intermetatarsal angle was reduced from 14.4 to 8.4 degrees by the wrapping technique, and their average metatarsophalangeal angle was spontaneously reduced from 31.8 to 21.8 degrees. After a minimum 1-year follow-up, they stabilized at 7.4 and 18.6 degrees, respectively. There was significant correlation between hallux valgus and metatarsus primus varus corrections by both forefoot wrapping and surgical methods with Spearman’s rank correlation of metatarsophalangeal angle and intermetatarsal angle corrections ( r = 0.6077, P < .0001 due to the wrapping method; r = 0.7157, P < .0001 due to the syndesmosis procedure). All raw working radiographic images for this study can be viewed in the Supplemental Material section.

Conclusion:

This study found that a simple forefoot tape-wrapping technique could be used preoperatively to verify first metatarsal mobility for metatarsus primus varus correction by the soft tissue syndesmosis procedure without osteotomies.

Level of Evidence:

Level II, prospective comparative study.
Epicutaneo-caval catheters in neonates: New insights and new suggestions from the recent literature
Authors: Barone Giovanni , Pittiruti Mauro
Published: December 2019

Epicutaneo-caval catheters have been widely used in neonatal intensive care units since Shaw has described them in 1973. These central venous access devices are usually placed at bedside and they have the purpose of delivering parenteral nutrition and/or drugs that are not compatible with the peripheral route. Even though in the last decade there was a fast advancement in the world of vascular access devices, such changes have only marginally affected the field of neonatal venous access. The aim of this editorial is to give 10 recommendations that correspond to 10 novelties in the field of epicutaneo-caval catheter: some are already evidence-based and should be introduced in our daily practice now, while others are particularly interesting and deserve further clinical studies.
Methodological and epistemological demands in advancing the study of subjectivity from a cultural-historical standpoint
Authors: González Rey Fernando
Published: December 2019

Historically, psychology has given little attention to the ontological definition of its main theoretical representations and has consequently avoided the epistemological and methodological challenges that new theoretical constructions should have implied. This fact, to some extent, has resulted from the rupture between psychology, particularly American psychology (Note: I refer to American psychology not only because it was characterized by this theoretical orientation, but also because at the beginning of the 20th century American psychology came to have a position of leadership in world psychology, due both to its level of organization as well as to its growing number of publications.), and philosophy and the other social sciences since the beginning of the 20th century. In fact, American psychology is strongly oriented toward being recognized as a natural science. In following that goal, methodology has been an object of special attention to the detriment of theory and epistemology. That “methodolatry,” has defined the trend in psychology of considering above on methodology as scientific, independent of the problems to be studied and of its requirements in terms of knowledge production. In fact, the methodology of psychology has oriented itself up until the present toward five main ontological definitions of what psyche is: behavioral, cognitivist, semiotic operational, linguistic, and discursive, with emotions being understood as epiphenomena within each of these representations.
Data linkage analysis of giant cell arteritis in Italy: Healthcare burden and cost of illness in the Italian region of Friuli Venezia Giulia (2001–2017)
Authors: Valent Francesca , Bond Milena , Cavallaro Elena , Treppo Elena , Rosalia Maria Da Riol , Tullio Annarita , Dejaco Christian , De Vita Salvatore , Quartuccio Luca
Published: December 2019

Giant cell arteritis (GCA) is the most common vasculitis in adults. However, comprehensive analyses of the healthcare burden are still scarce. The aim of the study is to report the healthcare burden and cost of illness of GCA in the Friuli Venezia Giulia (FVG) region of Italy, based on a data linkage analysis. To this end, a retrospective study was conducted through the integration of many administrative health databases of the FVG region as the source of information. Cases were identified from two verified, partially overlapping sources (the rare disease registry and medical exemption database). From 2001 to 2017, 208 patients with GCA were registered. The prevalence of GCA in the population aged ⩾ 45 years as of December 31, 2017 was 27.2/100,000 inhabitants (95% CI 23.5–31.4). The mean time of observation was 4.5 ± 3.6 years. A total of 3182 visits (338 per 100 patient-years) was recorded. The most frequent specialty visits were rheumatology ( n = 610, 19.2%), followed by internal medicine ( n = 564, 17.7%). A total of 287 hospitalizations (30 per 100 patient-years) were reported. A total of 13,043 prescriptions (1386 per 100 patient-years) were registered. More than half of the patients were prescribed an immunosuppressive agent. The overall estimated direct healthcare cost was €2,234,070, corresponding to €2374 per patient-year. Overall, GCA is a rare disease which implies a high healthcare cost.
Secret agents: Algorithmic culture, Goodreads and datafication of the contemporary book world
Authors: Murray Simone
Published: December 2019

Goodreads, the Anglophone world’s dominant book-centric social networking platform, is a compelling example of algorithmic selection of cultural goods. By exploring in detail Goodreads’s corporate history, financing arrangements and commodification of user data, the article poses questions about the designed opacity of algorithmic selection processes, their self-perpetuating cultural effects, and potential privileging of the commercial interests of corporate owner Amazon. More broadly, the article ponders the optimal theoretical and methodological tools for examining the 21st-century book world. It ponders the shortcomings of standard book history approaches and canvasses what cultural and media studies frameworks may add. Given the increasing interpenetration of bookish dispositions and digital technologies, the article argues it is time for these disciplines themselves to merge.
Response analysis of the nonlinear vibration energy harvester with an uncertain parameter
Authors: Huang Dongmei , Zhou Shengxi , Han Qun , Litak Grzegorz
Published: December 2019

In this paper, the Chebyshev polynomial approximation is firstly utilized to analyze the dynamical characteristics of the nonlinear vibration energy harvester with an uncertain parameter. First, the stochastic energy harvester is transformed into a high-dimensional equivalent deterministic system by the Chebyshev polynomial approximation. And the ensemble mean response of the stochastic energy harvester is introduced to discuss the stochastic response. Then, the effectiveness of the approximation method is verified by numerical results. Furthermore, the bifurcation property of the displacement and voltage is analyzed, which is also consistent with the results derived by the top Lyapunov exponent. It is found that random factor can induce the appearance of multi-periodic phenomena and lead to appear the behavior of the periodic bifurcation. The strong random factor induces the fluctuation of the output voltage. In addition, the existence of the random factor greatly influences the property of the sub-harmonics and super-harmonics of the spectrum. Overall, the response mechanism of the nonlinear vibration energy harvester with an uncertain parameter is revealed.
Unexpected cytosine–AuCl4− interaction under electrospray ionization mass spectrometry conditions—Formation of cytosine–Au(I) complexes
Authors: Frańska Magdalena , Konował Emilia
Published: December 2019

The interaction of cytosine with AuCl4−, under electrospray ionization mass spectrometric conditions, is discussed. On the basis of respective full scan mass spectra and product ion spectra, obtained in positive and negative ion mode, it has been deduced that cytosine is very prone to form Au(I)-containing complexes. The complexes may be formed in the gas phase by decomposition of Au(III)-containing complexes and also in the electrospray ionization source as a result of the occurrence of redox process. It has also been found that the interaction of cytosine with Au+ is stronger than that with Cu+ or Ag+, although taking into account the electrostatic attraction, it is not expected.
Catching the ghost: the digital gaze of motion capture
Authors: Chang Vanessa
Published: December 2019

Created with digital motion capture, or mocap, the virtual dances Ghostcatching and as.phyx.ia render movement abstracted from choreographic bodies. These depictions of gestural doubles or ‘ghosts’ trigger a sense of the uncanny rooted in mocap’s digital processes. Examining these material processes, this article argues that this digital optical uncanny precipitates from the intersubjective relationship of performer, technology, and spectator. Mocap interpolates living bodies into a technologized visual field that parses these bodies as dynamic data sets, a process by which performing bodies and digital capture technologies coalesce into the film’s virtual body. This virtual body signals a computational agency at its heart, one that choreographs the intersubjective embodiments of real and virtual dancers, and spectators. Destabilizing the human body as a locus of perception, movement, and sensation, mocap triggers uncanny uncertainty in human volition. In this way, Ghostcatching and as.phyx.ia reflect the infiltration of computer vision technologies, such as facial recognition, into numerous aspects of contemporary life. Through these works, the author hopes to show how the digital gaze of these algorithms, imperceptible to the human eye, threatens individual autonomy with automation.
A qualitative examination of the perceived impact of bureaucratic managerialism on evidence-based practice implementation in Nigeria: a collective case study
Authors: Ominyi Jude N , Agom David A , Ekuma Chidiebere Valentine
Published: December 2019

Background

Evidence-based practice (EBP) is widely recognised as an essential aspect of contemporary healthcare delivery. However, the rise in cost containment and quest for profitability in healthcare management is found to be compromising implementation of evidence-based initiatives aimed at improving care quality.

Aims

The aim of this work was to examine perspectives of nurses regarding the impact of bureaucratic managerialism on EBP implementation in the Nigerian acute care setting.

Methods

A qualitative case study methodology was utilised to gather data from two large acute care settings. Drawing on semi-structured interviews, 12 staff nurses, 21 ward managers and 2 nurse managers were interviewed. Data were inductively analysed and themes generated.

Results

The managerial practice in this context is founded on bureaucratic managerialism, which in turn generated hierarchical constraints that denied nurses the opportunity to self-govern. Implementation of evidence-based initiatives was consequently opposed by the managerial desire to maximise throughput.

Conclusions

There is need for nurse managers to have greater managerial influence, which would allow opportunities for implementing EBPs to be created. Managerial autonomy for nurse managers would allow them to create enabling environments capable of facilitating successful implementation.
Features of radiological and physiological findings in pulmonary capillary hemangiomatosis: an updated pooled analysis of confirmed diagnostic cases
Authors: Anazawa Rie , Terada Jiro , Sakao Seiichiro , Shigeta Ayako , Tanabe Nobuhiro , Tatsumi Koichiro
Published: December 2019

Pulmonary capillary hemangiomatosis (PCH) is a very rare and refractory disease characterized by capillary angioproliferation. The updated classification of pulmonary hypertension categorizes PCH into a subgroup of pulmonary arterial hypertension (PAH) alongside pulmonary veno‐occlusive disease (PVOD). However, the definitive diagnosis of PCH only with noninvasive tools remains difficult. The aim of this study was to elucidate the radiological and physiological characteristics of PCH. We searched for cases of pathologically confirmed PCH in the English literature published between 2000 and 2018. We identified 26 cases among 39 studies. Then, we extracted and evaluated the relevant clinical information in all cases with available data. On chest computed tomography (CT), ground‐glass opacities (GGOs) were observed in 92% of the cases, in which poorly defined nodular pattern was the most common (88%). GGOs in a bat‐wing distribution were observed in one case. Septal lines and lymph node enlargement were observed less frequently (each 19%, 12%). Seven cases (27%) had overlapping abnormalities. Diffusing capacity of the lung for carbon monoxide (DLCO) was remarkably decreased. Alveolar hemorrhage by histological findings or bronchoalveolar lavage (BAL) was observed in seven cases. The present study showed that the most characteristic findings of CT in PCH was centrilobular GGOs with a poorly defined nodular pattern, and septal lines and lymph node enlargement were seen less frequently. Alveolar hemorrhage detected by BAL and decreased DLCO may also be helpful to recognize the possibility of PCH like PVOD.
Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature
Authors: Takeshima Takao , Wan Qi , Zhang Yanlei , Komori Mika , Stretton Serina , Rajan Narayan , Treuer Tamas , Ueda Kaname
Published: December 2019

Background

The objective of this review was to determine the unmet needs for migraine in East Asian adults and children.

Methods

We searched MEDLINE and EMBASE (January 1, 1988 to January 14, 2019). Studies reporting the prevalence, humanistic and economic burden, and clinical management of migraine in China (including Hong Kong and Taiwan), Japan, and South Korea were included. Studies conducted before 1988 (before the International Headache Society [IHS] first edition of the International Classification of Headache Disorders) were not included.

Results

We retrieved 1337 publications and 41 met the inclusion criteria (28 from China, 7 from Japan, and 6 from South Korea). The 1-year prevalence of migraine (IHS criteria) among adults ranged from 6.0% to 14.3%. Peak prevalence ranged from 11% to 20% for women and 3% to 8% for men (30- to 49-year-olds). For children, prevalence of migraine increased with age. Information on the economic burden and clinical management of migraine was limited, particularly for children. When reported, migraine was significantly associated with high levels of disability and negative effects on quality of life. Studies suggested low levels of disease awareness/diagnosis within each country. Of individuals with migraine from China, 52.9% to 68.6% had consulted a physician previously, 37.2% to 52.7% diagnosed with headache had not been diagnosed with migraine previously, and 13.5% to 18% had been diagnosed with migraine previously. Of individuals with migraine from Japan, 59.4% to 71.8% had never consulted a physician previously, 1.3% to 7.3% regularly consulted physicians for their headache, and only 11.6% of individuals with migraine were aware that they had migraine. In addition, studies suggested that over-the-counter medication use was high and prescription medication use was low in each country.

Conclusions

This review suggests that there are unmet needs for migraine in terms of sufficient and appropriate diagnosis, and better management and therapies for treatment of migraine in East Asia. The findings are limited by a lack of recent information and significant gaps in the literature. More recent, population-based studies assessing disease burden and clinical management of migraine are needed to confirm unmet needs for migraine across East Asia.
Magnetic Assembly Route to Construct Reproducible and Recyclable SERS Substrate
Authors: Zou Bingfang , Niu Chunyu , Ma Ming , Zhao Lu , Wang Yongqiang
Published: December 2019

The fabrication of a uniform array film through assembly of colloidal building blocks is of practical interest for the integrated individual and collective functions. Here, a magnetic assembly route was put forward to organize monodisperse noble metal microspheres into a uniform array film for surface-enhanced Raman scattering (SERS) application, which demonstrated the integrated signal sensitivity of single noble metal microspheres and reproducibility of their assembled uniform array film. For this purpose, monodisperse multifunctional Fe3O4@SiO2@TiO2@Ag (FOSTA) colloidal microspheres as building blocks were successfully synthesized through a homemade ultrasonic-assisted reaction system. When used in SERS test, these multifunctional microspheres could firstly bind the analyte (R6G) from solution and then assembled into a uniform film under an external magnetic field, which exhibited high SERS detection sensitivity with good reproducibility. In addition, due to the TiO2 interlayer in FOSTA colloidal microspheres, the building blocks could be recycled and self cleaned through photocatalytic degradation of the adsorbed analyte for recycling SERS application.
Prostate cancer screening: assessment of knowledge and willingness to screen among men in Obio Akpor LGA, Rivers State, Nigeria
Authors: Enemugwem Rogers A. , Eze Beatrice A. , Ejike Ukamaka , Asuquo Eme O. , Tobin Alafaka
Published: December 2019

Background

Worldwide prostate cancer is the second most frequent cause of cancer deaths and is the commonest cancer diagnosed among Nigerian men. Screening techniques can be employed to detect the disease earlier in apparently healthy individuals, and increasing evidence shows that this can decrease morbidity and mortality of the disease. The objective of this study was to assess the knowledge and intention to screen for prostate cancer among men in Obio Akpor Local Government Area, Rivers State, Nigeria.

Results

Respondents were within the ages of 40 and 75 years. The most frequently reported source of information about prostate cancer screening was the news media 72 (35.0%) and healthcare workers 62 (30.1%). Thirty (14.9%) of the respondents had good knowledge of prostate cancer, while 80 (39.6%) had good knowledge of prostate cancer screening methods. Concerning prostate cancer screening methods, only 47 (23.3%) were able to correctly identify screening methods for prostate cancer. With regards to intention to screen, 104 (51.5%) were willing to be screened for prostate cancer.

Conclusion

This study showed that the knowledge of prostate cancer was poor with only approximately half of the participants expressing intentions to screen for the disease. This emphasizes the need for the Rivers State Ministry of Health to carry out awareness campaigns on the importance of prostate screening.
Evolution of cis- and trans-regulatory divergence in the chicken genome between two contrasting breeds analyzed using three tissue types at one-day-old
Authors: Wang Qiong , Jia Yaxiong , Wang Yuan , Jiang Zhihua , Zhou Xiang , Zhang Zebin , Nie Changsheng , Li Junying , Yang Ning , Qu Lujiang
Published: December 2019

Background

Gene expression variation is a key underlying factor influencing phenotypic variation, and can occur via cis- or trans-regulation. To understand the role of cis- and trans-regulatory variation on population divergence in chicken, we developed reciprocal crosses of two chicken breeds, White Leghorn and Cornish Game, which exhibit major differences in body size and reproductive traits, and used them to determine the degree of cis versus trans variation in the brain, liver, and muscle tissue of male and female 1-day-old specimens.

Results

We provided an overview of how transcriptomes are regulated in hybrid progenies of two contrasting breeds based on allele specific expression analysis. Compared with cis-regulatory divergence, trans-acting genes were more extensive in the chicken genome. In addition, considerable compensatory cis- and trans-regulatory changes exist in the chicken genome. Most importantly, stronger purifying selection was observed on genes regulated by trans-variations than in genes regulated by the cis elements.

Conclusions

We present a pipeline to explore allele-specific expression in hybrid progenies of inbred lines without a specific reference genome. Our research is the first study to describe the regulatory divergence between two contrasting breeds. The results suggest that artificial selection associated with domestication in chicken could have acted more on trans-regulatory divergence than on cis-regulatory divergence.