bluuebunny/crossref_metadata_2025 huggingface dataset:
Asset-оriented management of territorial communities: theoretical approaches
Authors: Storonyanska Iryna , Benovska Liliya
Published: December 2020

With the implementation of the reform of administrative and financial decentralization in Ukraine, the changes have occurred in managing the development of territorial communities in the direction of providing their self-development. Each territorial community has some resource potential, but the success of the development of community depends not only on the availability of resources, but on the ability to turn them into development assets. Therefore, when talking about the management of the assets of territorial communities, it is advisable to focus on two aspects: the own resource potential of the territorial community and the effective management aimed at transforming this resource into a community asset. The purpose of the article is to compare conceptual approaches to management with a focus on asset-oriented management of territorial community. Methods. The following methods were used for the study of asset-oriented management of the territorial community: historical, abstract and logical, systematic and comparative analysis. Results. The article analyzes the conceptual approaches to management: problem-oriented management, resource-oriented management, value-oriented management, asset-oriented management. Comparisons are made and the opportunities and expediency of their application for management of territorial community are analyzed. The necessity of using asset-oriented management of territorial community in the conditions of administrative and financial decentralization is substantiated. The features of asset-oriented management of the territorial community are characterized. It is stated that the goal of asset-oriented management is to increase the capacity of territorial communities by mobilizing their own resources and transforming them into community development assets. The assets of the territorial community were identified with grouping them into tangible and intangible assets. The technology of management of assets of territorial communities with separation of stages of management, purpose, subjects and objects of management, interconnections is developed.
Przed "Six years after". Notatki o powrocie pewnego archiwum filmowego w Gwinei-Bissau
Authors: Hering Tobias
Published: December 2020

W 2011 roku artystka Filipa César miała możliwość pracy w archiwach Instituto Nacional de Cinema e Audiovisual (INCA) w Bissau, w których przechowywane są materiały filmowe z okresu wojny wyzwoleńczej i pierwszych lat niepodległości Gwinei-Bissau (1972-1980). Razem z dwoma zaangażowanymi reżyserami z Gwinei-Bissau (Flora Gomes i Sana na N'Hada) i grupą badaczy i filmowców z tego kraju, Filipa César pracuje od tego momentu nad rozmaitymi, często eksperymentalnymi formami ukazania i rewaluacji tego archiwum. Tobias Hering uczestniczył na wielu poziomach w tym procesie i poświęcił temu projektowi esej "Before six years after", opublikowany z okazji wystawy Filipy César w Jeu de Paume w Paryżu (2012). Tekst ten jest rozszerzoną i krytycznie zrewidowaną wersją tamtego eseju.
Postcolonial Museum Laboratory, Clémentine Deliss in conversation with Joanna Sokołowska
Authors: Deliss Clémentine , Sokołowska Joanna
Published: December 2020

A conversation between Clémentine Deliss, the director of the Weltkulturen Museum in Frankfurt, and Joanna Sokołowska, curator at the Muzeum Sztuki in Łódź about new forms of research and exhibition at the Weltkulturen Museum in Frankfurt.
GESTIÓN AMBIENTAL EN LA ENSEÑANZA DE LA QUÍMICA ANALÍTICA
Authors: Espinosa Descalzo Espinosa Descalzo
Published: December 2020

El objetivo del presente artículo es generar reflexión respecto al compromiso docente de actualizarse en la problemática ambiental e introducir la asignatura Educación Ambiental en el desarrollo de los principales contenidos teóricos y prácticos de los cursos de la Escuela Profesional de Química en la formación de futuros profesionales quienes, además de dominar la ciencia, dentro de su campo y rango de acción, profundicen con el suficiente rigor, el compromiso con el ambiente, además de minimizar las emisiones nocivas que sus actividades generan, para contribuir al desarrollo sostenible. Una forma de incluir los principios de la Educación Ambiental, es mediante la realización de una gestión participativa en las prácticas de laboratorio, en base al principio de reducción en la fuente que, además de ayudar en la preservación ambiental, puede generar beneficios económicos como la disminución del consumo de reactivos del orden del 33,33 al 80 %. Asimismo, en el orden formativo, propicia el ejercicio del pensamiento crítico del estudiante y, motiva su participación activa como ciudadano en cuanto a los problemas ambientales, que no sólo son exclusivos al campo de la tecnología, además, tienen el encargo social de formar valores, actitudes y conductas que influyan en las personas y grupos de su entorno.
TEKNİĞİN İNSAN İLİŞKİLERİ ÜZERİNDEKİ ETKİSİNE DAİR BİR GÖZLEM
Authors: ÖREN Mehmet Furkan
Published: December 2020

Teknikle sosyal değişim ve dönüşüm arasındaki ilişki köklü bir tartışmadır. Mary Shelley’nin Frakenstein romanında güzel bir şekilde gösterdiği gibi teknik kimi zaman insan ilişkilerini dönüştürmekle kalmaz bazen ona hükmetmeye onu yönetmeye ve şekillendirmeye başlar. Matbaanın bulunması, teleskopun icadı, barutun kullanılması insanlık tarihine damga vurmuştur.
Bu yazıda Van’nın Saray ilçesine bağlı Yeşilalıç mahalle/köyünden hareketle tekniğin insan ilişkileri üzerindeki etkisine ilişkin saha gözlemlerine dayalı olarak analizler yapılacaktır. Nitel bir araştırma olan bu yazıda yaşlılarla yapılan görüşmelerden hareketle köye elektrik ve traktör gelmeden önceki insan ilişkileriyle sonraki ilişkiler karşılaştırılacaktır. Bu açıdan özellikle merkeze uzak, teknolojiyle görece sonradan tanışmış Yeşilialıç Köyü örneklem seçilmiştir. Buradaki temel amaç teknoloji öncesiyle teknik sonrası arasında net bir çıkarsama yapabilmektir. Elbette teknik geniş bir kavramdır. El arabası, kürek, tekerlek, orak gibi pek çok araç aslında tekniktir. Bu açıdan makalenin sınırlarını aşmamak için özellikle elektrik ve traktör odak olarak belirlenmiştir.
Do universal ao singular: algumas questões candentes no debate recente sobre gestão (democrática) da educação
Authors: Bettiolo dos Santos Aline , Nardi Elton Luiz
Published: December 2020

O artigo tem por objetivo analisar o debate carreado por produções científicas brasileiras da área da Educação, constantes no Portal Periódicos Capes e no Catálogo de Teses e Dissertações, acerca da gestão no campo das políticas educacionais, no período de 2015 a 2018. Com base no exame das produções sobre gestão democrática, sublinha como questões candentes a ênfase na dimensão técnica, nos limites e problemas e nas possibilidades. Destaca a dinâmica do capital, ainda mais recrudescida pela onda neoconservadora corrente desde os anos 1990, que tem dado lugar a medidas, como a introdução de mecanismos de accountability associados a processos de regulação da educação por resultados. Embora reconheça a democratização como um processo, ressalta a influência da lógica neoliberal de modo a esvaziar o sentido político e a estreitar o espaço da democracia na sociedade capitalista.
APRENDIZAGEM ESCOLAR DE CRIANÇAS COM AUTISMO E AS PRÁTICAS PEDAGÓGICAS DESENVOLVIDAS PELOS PROFESSORES
Authors: Christiane Cordeiro Silvestre Dalla Vecchia  , Carla Luciane Blum Vestena
Published: December 2020

O presente tem como objetivo expor e discutir, à luz do referencial teórico de Vygotsky, as análises feitas sobre as práticas pedagógicas dos professores do ensino fundamental regular da rede municipal de Guarapuava/PR que atuam na escolarização de crianças com autismo. É uma pesquisa qualitativa de cunho descritivo que contou com a participação de quatro professoras e duas crianças. Os instrumentos utilizados foram entrevista semiestruturada e observação, estas ocorreram em duas escolas regulares. Para o trato dos dados coletados foi utilizada a técnica da análise do discurso e a teoria proposta por acerca das categorias de mediação, zona de desenvolvimento proximal e dos níveis de desenvolvimento real e potencial. Os resultados apontam na direção de que, a partir do momento em que os professores se reconhecem como mediadores no processo de ensino, então conseguem passar a desenvolver práticas diferenciadas a fim de promover a aprendizagem em crianças com autismo.
Método clase invertida y desarrollo de competencias estadísticas en estudiantes de maestría
Authors: Ramón Ortiz Julia Ángela , Vilchez Jesús
Published: December 2020

El presente artículo trata sobre la gestión de datos en el proceso de investigación a nivel de estudios de maestría como parte de la formación continua del docente, y tuvo como objetivo determinar la efectividad del método Clase Invertida como estrategia didáctica en la mejora de la competencia estadística en estudiantes de maestría en educación, Universidad de Huánuco (Perú). La metodología utilizada fue la cuantitativa, diseño de estudio cuasiexperimental, con una muestra de 47 estudiantes distribuidos en dos grupos (control y experimental), al inicio se administra una prueba previa sobre conocimientos de estadística descriptiva, el proceso experimental se llevó a cabo en los temas: estimación de intervalo de confianza y prueba de hipótesis, durante ocho sesiones de clase en ambos grupos, al final de la intervención se administra la posprueba. Los resultados obtenidos muestran que las competencias previstas y el nivel de satisfacción fueron más significativo en el grupo experimental.  En conclusión, el método Clase Invertida es más efectiva que el método tradicional, para el logro de aprendizajes y el desarrollo de competencias estadísticas de los estudiantes de maestría.

e los estudiantes de maestría.
A disciplina de Libras como espaço de reflexões críticas e decoloniais na formação de professores
Authors: Gediel Ana Luisa Borba , Macedo Lopes Carolina , Alves Mourão Victor Luiz
Published: December 2020

Este trabalho tem como objetivo refletir sobre as implicações da disciplina de Libras na Formação de Professores, a partir das percepções de licenciandos de diferentes áreas do conhecimento. Em uma análise construída no campo da Linguística Aplicada e permeada pela discussão que envolve as políticas linguísticas e as noções de decolonialidade, discutimos a complexidade do desenvolvimento de uma disciplina a partir de múltiplas perspectivas. São pontuados os aspectos de padronização, reconhecimento, status linguístico e a igualdade de direitos dos grupos minoritários em usar sua primeira língua. A partir desse panorama, descrevemos a metodologia que proporcionou a realização da pesquisa. Em seguida discutimos o papel da disciplina de Libras para a construção de conhecimentos críticos tendo em vista sua organização em termos de conteúdos e objetivos, os quais envolvem a apreensão da Libras como primeira e como segunda língua, a interpretação de aspectos referentes à formação de professores voltada para a diversidade e inclusão e a relação do ensino da língua aliado a práticas pedagógicas. Para finalizar, concluímos que a disciplina tem um papel crítico reflexivo na formação dos futuros professores, envolvendo a construção de um olhar frente à língua e seu uso social.
MALİYE TEORİSİ PERSPEKTİFİNDEN TÜRKİYE’DE ERKEN ÇOCUKLUK DÖNEMİ EĞİTİMİNE İLİŞKİN KAMU POLİTİKASI METİNLERİNİN İNCELENMESİ
Authors: KARAGÖZ Berkan
Published: December 2020

Çalışmanın amacı, erken çocukluk dönemi eğitiminin dışsallıklarını teorik olarak inceleyerek ve Türkiye’deki erken çocukluk dönemi eğitimi kurumlarının ve metinlerinin neler olduğundan yola çıkılarak erken çocukluk dönemi eğitimi hedeflerini ortaya koymaktır. Erken çocukluk döneminde eğitime önem verilmesi; çocuklar arasında sınıf tekrarlama ve okulu terk etme oranlarını düşürmekte, daha üretken bir işgücüne sahip olunmasına katkıda bulunmakta, bebek ölüm oranlarını azaltmakta, ileriki dönemlerde okullaşma oranını arttırmakta, daha kalifiye yurttaşlara sahip olunmasını sağlamakta, suç oranlarını düşürmekte, cinsiyet rollerine bağlı eşitsizliği azalmakta, kadınların işgücüne katılımlarını arttırmakta, kente adapte olma koşullarını iyileştirmekte, ilköğretimin kalitesini arttırmakta ve nihayet eğitimin maliyetini düşürmekte olduğu bilimsel çevreler ve ilgili kuruluşlar tarafından ileri sürülmektedir. Türkiye’de ilgili yasal metinler ışığında ve ilgili politika metinlerde, 5 yaş üstü için erken çocukluk dönemi eğitiminin zorunlu hale getirilmesi, 3-6 yaş nüfusu için erken çocukluk dönemi okullaşma oranının %80 düzeyine çıkarılması planlandığı; kırsal kesimdeki çocuklar için değişik uygulamalarla kırsal kesim erken çocukluk dönemi okullaşma oranını arttırma hedefine sahip olunduğu görülmektedir. Milli Eğitim Bakanlığı 2019 Faaliyet Raporu istatistikleri incelendiğinde erken çocukluk dönemi okullaşma oranının %25 seviyesinde olduğu sonucuna ulaşılmıştır. Buna göre, 3-6 yaş nüfusun okullaşması için daha fazla kamu politikası üretilmesine gerek vardır.
Cantos que aprendemos nos sonhos: os grupos de canto/corais Ava-guarani e a transmissão de saberes através da experiência onírica na aldeia Ocoy/ Paraná.
Authors: Refatti Denize
Published: December 2020

Este artigo tem como mote principal descrever as relações existentes entre os sonhos e os Ava-guarani, refletindo principalmente sobre como os sonhos estão presentes na transmissão de saberes dos grupos de canto da aldeia indígena Ocoy, em São Miguel do Iguaçu – Paraná.   Considero que os sonhos são experiências coletivas que envolvem um conjunto de atividades, e possibilitam o acesso a um plano cosmológico que orienta a vida cotidiana. O artigo aponta para os modos como os cantos dos corais se afinam com a experiência onírica no que se refere aos conteúdos, às iniciações, à execução de instrumentos, entre outras dinâmicas que fazem parte das atividades dos grupos de canto.
ESCOLAS EM QUARENTENA: IMPLICAÇÕES DO ENSINO REMOTO NA REDE ESCOLAR PÚBLICA DURANTE O CURSO DA PANDEMIA DA COVID-19
Authors: SANTANA P. C. , ANTUNES Marcos H.
Published: December 2020

As escolas são espaços sociais que, em conjunto com a família e outras instituições, assumem a importante função de agenciar a mediação entre o indivíduo e a sociedade. Assim, para além de viabilizar a educação formal, as escolas são contextos promotores de desenvolvimento humano na medida em que as práticas desenvolvidas nas mesmas, ao transmitirem a cultura e, com ela, modelos socioculturais de comportamentos e valores morais, possibilitam aos indivíduos socializarem-se, exercerem autonomia e perceberem-se pertencentes a grupos (BOCK; FURTADO; TEIXEIRA, 2005).
TEST OF THE EFFECTIVENESS OF THE COMBINATION OF CUCUMBER JUICE (Cucumis sativus Linn,) AND LONG BEANS(Vigna sinensis (L.) Savi Ex Has.)ON THE WISTAR MALE RATS THAT IS INDUCED BY SUKROSA
Authors: Pratama Lumban Tobing Yoga , Robiyanto  , Sari Rafika
Published: December 2020

Diabetes mellitus is metabolic disorder caused by high glucose level due to abnormalities in insulin secretions, work or both that can be caused by alpha-glucosidase and alpha-amylase in intestine. Cucumbers (Cucumis sativus) and cowpeas (Vigna sinensis) are reported as anti-diabetic. The objective of the present study was to determine the effectiveness of cucumber-cowpea juice combination with single juice and metformin on lowering blood glucose level. Rats were made hyperglycemic by induced sucrose 6,825 g/Kg BW orally. Sample was taken on the lateral vein rat tail. Blood glucose levels were observed before and after juice induction in 30, 60, 90, and 120 minutes by using glucometer. The results were analyzed by Mann-Whitney methods. Single cucumber juice 14,11 g/Kg BW and combination cowpea-cucumber juice 26,4 g/Kg BW – 42 g/Kg BW were given the optimum effect. Both the optimum dose have significant level with metformin as positive control (p>0,05). Results showed that the combination have significant level on lowering blood glucose level compared with metformin.
Optimization of HDI West Kalimantan with the Education Sector Effectiveness Strategy
Authors: Kurniawati Dedek Kurniawati
Published: December 2020

Representasi dari hasil pembangunan yang optimal adalah indeks pendidikan yang efektif. Selain itu, ada dua komponen seperti indeks kesehatan dan indeks daya beli yang juga dapat membentuk IPM. Namun, dibandingkan kedua komponen tersebut indeks pendidikan yang relatif paling mempengaruhi IPM khususnya di Kalimantan Barat. Dengan demikian, diharapkan efektivitas pendidikan dapat menjadi solusi untuk mengoptimalkan IPM di Bidang lainnya.

 

Sesuai dengan program Gubernur Kalimantan Barat yang fokus untuk menyelenggarakan pendidikan gratis sebagai satu di antara dukungan dalam pengoptimalan IPM di Kalimantan Barat. Selain itu, peningkatan partisipasi masyarakat dalam pembangunan pendidikan juga perlu untuk dilaksanakan. Penerapan strategi jitu sebagai solusi untuk mengatasi permasalahan pada bidang pendidikan perlu untuk dilakukan secara optimal. Berdasarkan upaya tersebut diharapkan dapat menjawab berbagai permasalahan yang ada di Kalimantan Barat khususnya terkait IPM di Kalimantan Barat.
PENGARUH DENDA PAJAK KENDARAAN BERMOTOR TERHADAP PERILAKU TAAT PAJAK
Authors: Sabinus Sabinus
Published: December 2020

Penelitian dilakukan di Kabupaten Bengkayang terhadap wajib pajak kendaraan bermotor. Penelitian dilakukan karena data tunggakan pajak kendaraan bermotor yang cukup besar di Kalimantan Barat yakni sebesar 920 miliar rupiah yang berpengaruh terhadap potensi penerimaan asli daerah Provinsi Kalimantan Barat. Kondisi ini perlu mendapat perhatian seluruh stakeholders agar tidak terus terjadi karena dapat berefek pada berkurangnya pendapatan asli daerah (PAD) Provinsi Kalimantan Barat. Penelitian bertujuan untuk mengetahui upaya pemerintah dalam meningkatkan realisasi pembayaran pajak kendaraan bermotor dan untuk mengetahui sejauh mana denda berpengaruh terhadap perilaku taat pajak. Manfaat penelitian ini untuk memberikan rekomendasi dalam memformulasikan dan mengevaluasi agar terciptanya mas.yarakat taat pajak kendaraan bermotor. Metode penelitian menggunakan metode kuantitatif dengan berdasarkan data tunggakan pajak kendaraan bermotor yang dipublikasikan oleh Badan Pendapatan Daerah Provinsi Kalimantan Barat serta melakukan wawancara dan penyebaran kuisioner secara daring mulai Februari hingga April tahun 2020. Hasil penelitian menunjukkan perlu adanya sanksi administrasi (denda) keterlambatan pembayaran pajak kendaraan bermotor tetapi dikenakan bukan pada tahun berjalan melainkan pada tahun berikutnya serta harus adanya inovasi system pemberitahuan/notifikasi dari samsat/bapenda secara daring kepada wajib pajak bahwa jatuh tempo pajak sudah berkahir dan adanya penagihan secara langsung oleh petugas.

Kata kunci: Pajak Kendaraan Bermotor, Perilaku, Pendapatan Asli Daerah
Work, Life, and Identity Negotiation in a Foreign Land: A Study of Taiwanese Working Holiday Makers in Belgium
Authors: Lin Hsien Ming , Pang Ching Lin , Liao Da Chi
Published: December 2020

This study examined the living and working experiences of 14 Taiwanese working holiday makers (WHMs) in Belgium as they negotiate their identity and social lives while they live overseas, using both participant observation and semi-structured interviews. The study demonstrates that the low salary level and high work pressure in Taiwan are two of the major factors pushing these young Taiwanese to leave their homeland and work overseas. However, the majority of these Taiwanese WHMs face difficulties in speaking Belgium’s local languages, and their opportunities for work are further limited by the temporary visa regulations. Workplaces run by mainland Chinese, especially in the hospitality industry, have become vital places for Taiwanese WHMs to negotiate their ethnonational identity. Although they only have limited social lives and networks in the host society, they claim that they have developed intercultural competences and a greater open-mindedness by living in the multicultural and international environments of Brussels or other Belgian cities.
Recomendações sobre design informacional aplicado em motion graphics
Authors: Fronza André Luiz , Blum Arina , Meürer Mary Vonni
Published: December 2020

Tendo sua origem no cinema, o motion graphics tornou-se uma linguagem audiovisual bastante difundida a partir dos anos 1990 devido ao avanço tecnológico na área da computação gráfica. É caracterizado por concentrar-se em uma área de criação que permite a combinação e manipulação de ilustrações, elementos gráficos, fotografia e vídeos, num determinado espaço-tempo unido ao uso de música e efeitos sonoros. Neste contexto, o presente artigo relata a pesquisa que objetivou identificar se, para o público jovem, o motion graphicstransmite informações com maior efetividade do que um material estático. Também buscou-se compreender o processo de criação e concepção do motion graphics, tendo o intuito de futuramente formular um guia para os profissionais da área a fim de auxiliá-los no processo de organização visual e cognitiva da mensagem em projetos desse tipo. Para alcance dos objetivos propostos, foi realizada uma pesquisa d  e caráter misto, do tipo exploratória, utilizando dados quantitativos obtidos a partir de um questionário fechado aplicado a alunos de Ensino Médio e informações qualitativas provindas de dois focus group com estudantes de Design. Constatou-se que há diferenças na percepção de informações estáticas em comparação às animadas (motion graphics) e que o motion designer, ao projetar uma animação,deve ter primor na aplicação dos princípios básicos que concernem o design da informação.
Dr. Rune Pettersson
Authors: Padovani Stephania
Published: December 2020

Rune Pettersson, Ph.D., is Professor de Design de Informao no Departamento de Inovao, Design e Desenvolvimento de Produto na Universidade de Mlarden, Eskilstuna, Sweden. Ele ainda presidente da Art Design, Faculdade de Cincia e Tecnologi. Dr Pettersson foi Vice Presidente do Instituto Internacional de Design de Informao (International Institute for Information Design), IIID. Tambm foi Vice President da International Visual Literacy Association, IVLA, seis vezes e presidente durante o perodo de 2000-2001. Tambm foi conselheiro internacional para o International Division of the Association for Educational Communications and Technology. Publicou 206 teses e 65 livros. [ Download ]
Estudo experimental de leitura de uma bula de medicamentos, transcrita para o Sistema Braille, por usuários portadores de cegueira
Authors: Lopes Maria Olinda , Spinillo Carla Galvão
Published: December 2020

Nesse artigo descrito um estudo experimental realizado com usurios portadores de cegueira.Estes fizeram a leitura de uma bula de medicamentos transcrita para o Sistema Braille. Para tanto foi desenvolvido uma entrevista com a aplicao do modelo de apresentao grfica de Karel van der Waarde. O objetivo desse estudo experimental foi o de avaliar a bula em suas caractersticas grficas e informacionais para o usurio cego. [ Download ]
Sistemas semióticos, artefatos cognitivos, Umwelt – uma contribuição ao Design da Informação
Authors: Queiroz João
Published: December 2020

O desenvolvimento e a anlise de ambientes, nichos e paisagens semiticas (semiotic landscapes) podecaracterizar com preciso parte das atividades do Design da Informao. Este trabalho exploraintrodutoriamente esta perspectiva, atravs das noes de artefato cognitivo e semitico, sistemasemitico e Umwelt. Ele se inscreve em um domnio terico em que associa processos semiticos,tecnologias e artefatos cognitivos, e baseia-se em tratamentos empricos, em Ecologia Comportamental,Etologia, e Semitica Cognitiva. [ Download ]
Agentes folkcomunicacionales y memoria colectiva: organizando el territorio desde la experiencia popular
Authors: Mancilla Ivaca Nastassja
Published: December 2020

Nosso artigo é parte de uma pesquisa em andamento que ocorre na região de Los Ríos, sul do Chile, onde ex-moradores buscam recuperar territórios do Complexo Florestal e Madeireiro de Panguipulli (COFOMAP) de onde foram deslocados à força durante a ditadura militar (1973-1989). O objetivo é analisar as práticas de comunicação popular de agentes que dão sentido à apropriação do espaço da cultura popular, que emerge na memória coletiva e fortalece a organização, dimensão que foi identificada a partir do trabalho de campo que incluiu entrevistas grupais e observação participante. Assim, articula-se uma narrativa resistente à expropriação corporativa e ao vívido terrorismo de Estado, conferindo inteligibilidade à luta atual e às demandas por justiça. Memória coletiva; Terrorismo de Estado; Práticas folkcomunicacionais; Deslocamento forçado.
LA PROTECCIÓN DE LOS DERECHOS FUNDAMENTALES EN EL ESPACIO EUROPEO Y LOS DIVERSOS ESTÁNDARES POSIBLES DE PROTECCIÓN: EL CASO DEL RECONOCIMIENTO DE LA DIMENSIÓN SOCIAL DEL DERECHO A LA VIVIENDA POR PARTE DEL TEDH
Authors: Drigo Caterina
Published: December 2020

El presente trabajo se propone clarificar los múltiples contornos de los derechos a la vivienda, con una particular referencia a la dimensión regional europea evidenciando los elementos de juicio utilizados por el TEDH. En concreto, la tutela de los derechos a la vivienda sigue diferentes vías, con la combinación de una pluralidad de mecanismos de protección que pueden combinarse de manera variada entre ellos y que son, ante todo, de carácter político, pero que implican también la intervención de medidas de carácter administrativo y jurisdiccional.

“The protection of fundamental rights in Europe and the possible protection standards: Case study on the recognition of the social dimension of housing rights by the ECtHR.”

 Abstract

With this work we aim to clarify the multifaceted contours of housing rights, with particular reference to the European context, highlighting the standards of judgment used by the ECHR. In particular, the protection of house rights follows various and articulated paths, making use of the combination of a plurality of protection mechanisms that can variously combine and which are primarily political, but which also impose the intervention of administrative and jurisdictional measures.
EFEITO DA APLICAÇÃO DE HERBICIDAS SUPOSTAMENTE ANTAGÔNICOS SOBRE PLANTAS DE ARROZ SUSCETÍVEIS A INIBIDORES DA ENZIMA ACCASE
Authors: Silva Renan Souza , Camargo Edinalvo Rabaioli , Fipke Marcus Vinícius , Andres André , Noldin José Alberto , Kruse Nelson Diehl , De Avila Luis Antonio
Published: December 2020

O controle do arroz-daninho tem sido foco de pesquisas na área de herbologia. Contudo, a ocorrência de fluxo gênico do arroz Clearfield (CL) para a espécie daninha tem resultado em perda na eficiencia do sistema de produção CL. Uma nova cultivar de arroz, resistente a herbicidas inibidores da ACCase, será lançada no mercado e se constitui em mais uma ferramenta para o manejo do arroz-daninho em lavouras de arroz irrigado. Aliada a essa ferramenta, existe a necessidade de aumento no espectro dos tratamentos herbicidas para o controle da diversidade de espécies de plantas daninhas infestantes nas lavouras de arroz irirgado. O objetivo deste estudo foi elucidar o efeito de herbicidas latifolicidas na ação graminicida do quizalofop sobre o arroz cultivado como planta indicadora na simulação de arroz-daninho. Foi realizado um experimento, em casa de vegetação na Epagri-Estação Experimental de Itajaí (SC). Os resultados obtidos indicam que houve redução da eficiência de controle do arroz em todas as doses avaliadas das associações de quizalofop com 2,4-D.
Predictors of Long‐Term Outcome of Subthalamic Stimulation in Parkinson Disease
Authors: Cavallieri Francesco , Fraix Valérie , Bove Francesco , Mulas Delia , Tondelli Manuela , Castrioto Anna , Krack Paul , Meoni Sara , Schmitt Emmanuelle , Lhommée Eugénie , Bichon Amélie , Pélissier Pierre , Chevrier Eric , Kistner Andrea , Seigneuret Eric , Chabardès Stephan , Moro Elena
Published: December 2020

Objective

This study was undertaken to identify preoperative predictive factors of long‐term motor outcome in a large cohort of consecutive Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN‐DBS).

Methods

All consecutive PD patients who underwent bilateral STN‐DBS at the Grenoble University Hospital (France) from 1993 to 2015 were evaluated before surgery, at 1 year (short‐term), and in the long term after surgery. All available demographic variables, neuroimaging data, and clinical characteristics were collected. Preoperative predictors of long‐term motor outcome were investigated by performing survival and univariate/multivariate Cox regression analyses. Loss of motor benefit from stimulation in the long term was defined as a reduction of less than 25% in the Movement Disorder Society–sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) part III scores compared to the baseline off‐medication scores. As a secondary objective, potential predictors of short‐term motor outcome after STN‐DBS were assessed by performing univariate and multivariate linear regression analyses.

Results

In the long‐term analyses (mean follow‐up = 8.4 ± 6.26 years, median = 10 years, range = 1–17 years), 138 patients were included. Preoperative higher frontal score and off‐medication MDS‐UPDRS part III scores predicted a better long‐term motor response to stimulation, whereas the presence of vascular changes on neuroimaging predicted a worse motor outcome. In 357 patients with available 1‐year follow‐up, preoperative levodopa response, tremor dominant phenotype, baseline frontal score, and off‐medication MDS‐UPDRS part III scores predicted the short‐term motor outcome.

Interpretation

Frontal lobe dysfunction, disease severity in the off‐medication condition, and the presence of vascular changes on neuroimaging represent the main preoperative clinical predictors of long‐term motor STN‐DBS effects. ANN NEUROL 2021;89:587–597
Novel Mn(II) and Zn(II) complexes of 6‐bromopicolinic acid as a potential optical material: Synthesis, spectral characterizations, linear, and nonlinear optical properties and density functional theory calculations
Authors: Avcı Davut , Saeedi Yalda , Başoğlu Adil , Dege Necmi , Altürk Sümeyye , Tamer Ömer , Atalay Yusuf
Published: December 2020

The Mn(II) and Zn(II) complexes of 6‐bromopicolinic acid (6‐BrpicH) were synthesized for the first time, and their molecular structures were determined by X‐ray diffraction (XRD) technique. The detailed experimental spectral studies were executed by Fourier‐transform infrared (FT‐IR) and UV–Vis spectra. The experimental optical properties, such as refractive index, linear polarizability, optical susceptibility, optical band gap, extinction coefficient, dielectric constant, and volume energy loss function (VELF) and surface energy loss function (SELF) parameters obtained from the transmission spectra with solution technique in ethanol solvent of these complexes, were investigated. Additionally, the refractive index (n), optical band gap, χ(1) (linear optical susceptibility), χ(3) (third‐order nonlinear optical susceptibility), and first‐ and second‐hyperpolarizability (β and γ) parameters were surveyed by using density functional theory (DFT)/HSEh1PBE/6‐311G(d,p)/LanL2DZ level. The experimental and theoretical optical band gap energies of complex 2 were obtained at 4.26 and 4.67 eV. The experimental and theoretical n values of complex 1 in the mid‐IR region were found to be 1.581 and 1.58 (in gas phase). The experimental linear optical
and χ(1) parameters were calculated at 31.73 × 10−24 and 14.58 × 10−2 esu for complex 1 in the mid‐IR region; the corresponding theoretical parameters for complex 1 in the gas phase were obtained at 36.07 × 10−24 and 18.35 × 10−2 esu. The second‐order nonlinear optical (NLO) results exhibit that complex 1 is a promising candidate to materials with the high second‐order hyperpolarizability values obtained as 540.71 × 10−36 and 56.83 × 10−36 esu in ethanol solvent and gas phase. Moreover, the intermolecular and intramolecular bonding and the definition of coordination geometries around the central metal ions, as well as the electronic charge transfer interactions in the Mn(II) and Zn(II) complexes, were confirmed by natural bond orbital (NBO) analysis. To sum up, the detailed experimental and theoretical structural, spectroscopic, electronic, and optical properties of the synthesized complexes were comparatively presented.
Indirect Formic Acid Fuel Cell Based on a Palladium or Palladium‐Alloy Film Separating the Fuel Reaction and Electricity Generation
Authors: Madrid Elena , Harabajiu Catajina , Hill Robyn S. , Black Kate , Torrente‐Murciano Laura , Dickinson Angus J. , Fletcher Philip J. , Ozoemena Kenneth I. , Ipadeola Adewale K. , Oguzie Emeka , Akalezi Chris O. , Marken Frank
Published: December 2020

An indirect fuel cell concept is presented herein, where a palladium‐based membrane (either pure Pd with 25 μm thickness or Pd75Ag25alloy with 10 μm thickness) is used to separate the electrochemical cell compartment from a catalysis compartment. In this system, hydrogen is generated from a hydrogen‐rich molecule, such as formic acid, and selectively permeated through the membrane into the electrochemical compartment where it is then converted into electricity. In this way, hydrogen is generated and converted in situ, overcoming the issues associated with hydrogen storage and presenting chemical hydrogen storage as an attractive and feasible alternative with potential application in future micro‐ and macro‐power devices for a wide range of applications and fuels.
Naphthalimide‐Based Hydrazone Derivatives: Synthesis, Mechanochromism in the Solid State and Response to Ions in Dilute Solutions
Authors: Shi Shuai , Gu Pei‐Yang , Zhou Shiyuan , Zhu Yutao , He Jinghui , Xu Qingfeng , Lu Jianmei
Published: December 2020

Molecules showing mechanochromic luminescence (MCL) are promising for use in the in the fields of sensing and probes. We report the design and synthesis of new naphthalimide‐based hydrazone derivatives, NI‐TPE and NI‐3BA. Both the luminogens are weakly emissive with sΦf=0.3 % and 0.5 % respectively when aggregated in amorphous states as strong π‐π stacking and intermolecular interaction prevent luminescence. On the contrary, in the crystalline state, single crystal analysis of two derivatives shows that nonradiative decay is reduced or inhibited by molecular stacking modes and intermolecular interactions. Increases of fluorescence emission intensity to sΦf=5.5 % and 6.0 % upon solvent evaporation are attributed to weak π‐π overlapping and hydrogen bonding (N−H ⋅⋅⋅ O, distance 2.99 Å), which are beneficial to the formation of molecules with a loose packing. At the same time, the packing modes that the two derivatives adopt in the crystal lattice are destroyed to result in a low solid‐state fluorescence quantum yield and a bathochromic shift of 23–25 nm upon grinding. All these factors cause the two derivatives show an unusual “turn off” MCL phenomenon. The fluorescence emission, its pH reversibility, and selective response to fluoride and acetate ions of up to 91–93 % in dilute solutions were also demonstrated.
Knockdown of lactate dehydrogenase by adeno‐associated virus‐delivered CRISPR/Cas9 system alleviates primary hyperoxaluria type 1
Authors: Zheng Rui , Fang Xiaoliang , Chen Xi , Huang Yunteng , Xu Guofeng , He Lei , Li Yueyan , Niu Xuran , Yang Lei , Wang Liren , Li Dali , Geng Hongquan
Published: December 2020

Background

Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder caused by endogenous overproduction of hepatic oxalate, leading to hyperoxaluria, recurrent calcium oxalate kidney stones, and end‐stage renal disease. Lactate dehydrogenase (LDH) is an ideal target for diminishing oxalate production as it is responsible for glyoxylate to oxalate conversion in the liver, the last step of oxalate metabolism. Here, we investigated the therapeutic efficacy and potential side effects of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology to ameliorate PH1 via specifically disrupting the hepatic LDH.

Methods

Pheochromocytoma (PC12) cells were used to assess the efficacy of cleavage of single‐guide RNAs in vitro. PH1 neonatal rats were injected with a single administration of adeno‐associated virus to deliver the CRISPR/Cas9 system that targeted LDH. Three weeks after injection, a liver biopsy was performed to detect LDH expression, liver injury, and liver metabolomics. Urinary oxalate was regularly monitored, and renal calcium oxalate deposition was evaluated after 4 weeks of 0.5% ethylene glycol challenge. After 6 months of treatment, animals were euthanized, and ex‐liver organs were harvested for toxicity analysis.

Results

The Ldha gene was specifically knocked out in 20% of the liver cells of PH1 rats in the treatment group, leading to a 50% lower LDH expression than that in the control group. Compared to the control groups, urinary oxalate levels were significantly decreased, and renal calcium oxalate precipitation was largely mitigated in the treatment group throughout the entire 6‐month study period. While no CRISPR/Cas9‐associated off‐target edits or hepatotoxicity were detected, we observed mild metabolic changes in the liver tricarboxylic acid (TCA) and glycolysis pathways.

Conclusions

CRISPR/Cas9‐mediated LDH disruption may represent an applicable new strategy for alleviating PH1 for its long‐lasting effect and low editorial efficiency requirements.
Influence of surface resistivity of insulation films on penetration phenomenon by negative lightning impulse discharge
Authors: Mizusaki Masayuki , Araoka Nobutaka , Takamura Norimitsu , Sasaki Yuki , Ryu Terumasa , Matsuda Mikiya , Namihira Takao , Hanai Masahiro
Published: December 2020

A method is needed to prevent damage of wind power generators from lightning strikes even if lightning strikes the blades. In our experiment, the discharge progressing to the film was hard to penetrate the low surface resistivity polyethylene terephthalate (PET) films with conductive coating on one side, although the discharge always penetrated the uncoated PET film. This result was confirmed when the coated surface of the film was directed to either the high voltage rod electrode side or the ground plate electrode side. It was also confirmed that the progress of negative leader generated from the high voltage rod electrode side was hindered by the film from the photograph with the high speed camera. The time constant was calculated from the product of the surface resistance and the capacitance between the film and the plate electrode. As a result, it was suggested that the propagation of electric potential might be fast because time constant is smaller in the case of the low surface resistivity PET films.
Structural analysis of a compound despite the presence of an isobaric interference by using in‐source Collision Induced Dissociation and tandem mass spectrometry
Authors: Jeanne Dit Fouque Dany , Maroto Alicia , Memboeuf Antony
Published: December 2020

The presence of an isobaric contaminant can drastically affect MS and MS/MS patterns leading to erroneous structural and quantitative analysis, which is a real challenge in mass spectrometry. Herein, we demonstrate that MS and MS/MS structural analysis of a compound can be successfully performed despite the presence of an isobaric interference with as low as few millidaltons mass difference by using pseudo‐MS3. To this end, in‐source collisional excitation (in‐source CID) and the Survival Yield (SY) technique (energy‐resolved collision induced dissociation MS/MS) were performed on two different source geometries: a Z‐spray and an orthogonal spray (with a transfer capillary) ionization sources on two different mass spectrometers. By using soft ionization conditions, the SY curve for the mixture is a linear combination of the SY curves from the pure compounds demonstrating the presence of two components in the mixture. In the case of harsher ionization conditions, the SY curve of the mixture perfectly overlaps the SY curve from the pure analyte. This observation demonstrates the isobaric interference has been completely removed by in‐source CID fragmentation, independently of the source design, leaving then the analyte precursor ions only. Therefore, by measuring the MS spectrum in harsh ionization conditions and according to SY criterium, the compound of interest can be made free from isobaric interference paving the way for, for example, unequivocal HPLC‐MS as well as HPLC‐MS/MS structural and quantitative analysis despite the presence of a co‐eluting isobaric interference.
Portal Vein Complications After Adult Living Donor Liver Transplantation: Time of Onset and Deformity Patterns Affect Long‐Term Outcomes
Authors: Sambommatsu Yuzuru , Shimata Keita , Ibuki Sho , Narita Yasuko , Isono Kaori , Honda Masaki , Irie Tomoaki , Kadohisa Masashi , Kawabata Seiichi , Yamamoto Hidekazu , Sugawara Yasuhiko , Ikeda Osamu , Inomata Yukihiro , Hibi Taizo
Published: December 2020

Portal vein complications (PVCs) after adult living donor liver transplantation (LDLT) are potentially lethal. We categorized PVCs by the time of onset (early versus late, <1 month versus ≥1 month, respectively) and deformity patterns (portal vein stenosis [PVS], portal vein thrombosis [PVT], and portal vein occlusion [PVO]) to establish optimal treatment strategies. Overall, 35/322 (10.9%) recipients developed PVCs between 2000 and 2019. Pretransplant PVT (odds ratio [OR], 15.20; 95% confidence interval [CI], 3.70‐62.40; P < 0.001) was the only independent risk factor for PVS. In contrast, male sex (OR, 5.57; 95% CI, 1.71‐18.20; P = 0.004), pretransplant PVT (OR, 4.79; 95% CI, 1.64‐14.00; P = 0.004), and splenectomy (OR, 3.24; 95% CI, 1.23‐8.57; P = 0.018) were independent risk factors for PVT. PVS was successfully treated with interventional radiology regardless of its time of onset. On the other hand, late PVT and PVO had significantly lower treatment success rates (2/15, 13%) compared with those that occurred in the early period (10/11, 91%) despite aggressive intervention (P < 0.001). Deformity patterns had a significant impact on the 5‐year cumulative incidence of graft loss as a result of PVC (PVO + Yerdel grades 2‐4 PVT group [n = 16], 41% versus PVS + Yerdel grade 1 PVT group [n = 19], 0%; P = 0.02). In conclusion, late grades 2 to 4 PVT and PVO are refractory to treatment and associated with poor prognoses, whereas PVS has a good prognosis regardless of time of onset. A tailored approach according to the time of onset and deformity patterns of PVC is essential.
Targeted nanomedicines for the treatment of bone disease and regeneration
Authors: Ordikhani Farideh , Zandi Nooshin , Mazaheri Mozhdeh , Luther Gaurav A. , Ghovvati Mahsa , Akbarzadeh Abolfazl , Annabi Nasim
Published: December 2020

Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone‐targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical applications. In the present review, the latest advancements in targeting moieties and nanocarrier drug delivery systems for the treatment of bone diseases are summarized. We also review the regeneration capability and effective delivery of nanomedicines for orthopedic applications.
Flow Conditioning of Hatchery-Reared Razorback Sucker Increases Apparent Survival in the Wild
Authors: Franssen Nathan R. , Durst Scott L. , Gilbert Eliza I. , Knight William K. , Ulibarri Manuel
Published: December 2020

Hatchery augmentation of dwindling wild populations has become a common strategy to avoid extinction of endangered fishes. While benign hatchery conditions can lead to low persistence of stocked individuals, experiments have demonstrated that flow conditioning of Razorback Sucker Xyrauchen texanus can increase swimming performance and reduce downstream movements from desired locations after stocking in the Colorado River basin, USA. However, managers have been slow to adopt its use, likely because linking experimental flow conditioning to scales that are relevant to conservation has been difficult. We reared age-2 Razorback Sucker in two raceways (control: n = 530; flow conditioning: n = 533) for 10 weeks to assess whether flow conditioning could increase apparent survival after stocking into the San Juan River, New Mexico. We used riverwide active sampling and remote PIT tag antennas to resample individuals for 3 years after stocking. Using Cormack–Jolly–Seber mark–recapture models, we assessed the effects of flow conditioning, size at stocking, relative condition (Fulton’s K), and their interactions on apparent survival and downstream movement after stocking. Flow conditioning of fish doubled the mean apparent survival (at a mean size of 325 mm TL) during the first overwinter period (control fish: 0.14, 95% CI = 0.09–0.21; flow-conditioned fish: 0.28, 95% CI = 0.19–0.38), with both groups having similar mean overwinter apparent survival estimates thereafter (both > 0.75). Size at stocking and K were positively associated with first-overwinter apparent survival regardless of treatment (mean survival was <0.20 for fish <275 mm TL but was >0.65 for fish >450 mm TL). Downstream movement after stocking was negatively associated with fish size, indicating that emigration likely contributed to higher apparent mortality of smaller fish. Our results suggest that transitioning hatchery practices to include flow conditioning of Razorback Sucker (and potentially other endangered Colorado River fishes) prior to stocking could substantially increase the conservation efficiency of these augmentation programs.