bluuebunny/crossref_metadata_2025 huggingface dataset:
Formation of intracellular vesicles within the Gram+ Lactococcus lactis induced by the overexpression of Caveolin-1β
Authors: Flourieusse Anthony , Bourgeois Pauline , Schenckbecker Emma , Palvair Jovanne , Legrand Déborah , Labbé Clarisse , Bescond Thomas , Avoscan Laure , Orlowski Stéphane , Rouleau Alain , Frelet-Barrand Annie
Published: July 2022

Background: Caveolae are invaginated plasma membrane domains of 50-100 nm in diameter involved in many important physiological functions in cells. They are composed of different proteins, including the membrane-embedded caveolins and the peripheric cavins. Caveolin-1 has already been expressed in various expression systems (E. coli, insect cells, Toxoplasma gondii, cell-free system), generating intracellular caveolin-enriched vesicles in E. coli, insect cells and T. gondii. These systems helped to understand the protein insertion within the membrane and its oligomerization. There is still need for fundamental insights into the formation of specific domains on membrane, deformation of a biological membrane driven by caveolin-1, the organization of a caveolar coat, and the requirement of specific lipids and proteins during the process. The aim of this study was to test whether the heterologously expressed caveolin-1β was able to induce the formation of intracellular vesicles within a Gram+ bacterium, Lactococcus lactis, since it displays a specific lipid composition different from E. coli and appears to emerge as a good alternative to E. coli for efficient overexpression of various membrane proteins.Results: Recombinant bacteria transformed with the plasmid pNZ-HTC coding for the canine isoform of caveolin-1β has been shown to produce caveolin-1β, under its functional oligomeric form, at a high expression level unexpected for an eukaryotic membrane protein. Electron microscopy revealed several intracellular vesicles from 30 to 60 nm, a size comparable to E. coli h-caveolae, beneath the plasma membrane of the overexpressing bacteria, showing that caveolin-1β is sufficient to induce membrane vesiculation. Immunolabelling studies showed antibodies on such neo-formed intracellular vesicles, but none on plasma membrane. Density gradient fractionation allowed the correlation between detection of oligomers on Western blotting and appearance of vesicles measurable by DLS, showing the requirement of caveolin-1β oligomerization for vesicle formation. Conclusion: These caveolin-1β enriched intracellular neo-formed vesicles might be useful for potential co-expression of membrane proteins of pharmaceutical interest for their simplified functional characterization.
Eating behavior and physical activity leading to gender differences in overweight and obesity among college students in China
Authors: Mu Lianwei , Qiu Ping-xue , Wang Hai-ying
Published: July 2022

Overweight and obesity are showing an increasing prevalence among college students. But gender differences related to overweight and obesity in Chinese college students have not been adequately characterized. This cross-sectional study aimed to investigate the gender differences in overweight and obesity among college students, then, investigate why these gender differ-ences exist. A total of 622 undergraduate students (females: N = 245, male: N = 377), aged 18–23 years, were recruited from the Hebei Sport University in China. Anthropometric data, physical activity and sedentary behaviors, eating behaviors (cognitive restraint, uncontrolled eating, and emotional eating) and food addiction were collected through anthropometric measurements and questionnaires that included the International Physical Activity Questionnaire short-form (IPAQ-SF), the Modified Food Addiction Scale version 2.0 (mYFAS 2.0), and the Three Factor Eating Questionnaire (TFEQ). Here, we show that female college students had a significantly higher prevalence of overweight and obesity (Female: BFP ≥ 25%; Male: BFP ≥ 20%) than male students. Meanwhile, Female college students had a higher mean body fat percentage (BFP) and a lower waist circumference, waist-to-hip ratio, visceral fat area, fat-free mass, muscle mass, and skeletal muscle mass compared to male college students. Additionally, female college students were more likely to be moderate physical activity than males, while male college students were more likely to be severe physical activity. Female college students had significantly higher mean scores for cognitive restraint, uncontrolled eating, and emotional eating than males. Our findings indicated that the higher prevalence of overweight and obesity rates in female college students than male students may be due to de differences in physical activity and eating behavior.
Clusterwise multivariate regression of mixed-type panel data
Authors: Vávra Jan , Komárek Arnošt , Grün Bettina , Malsiner-Walli Gertraud
Published: July 2022

Multivariate panel data of mixed type are routinely collected in many different areas of application, often jointly with additional covariates which complicate the statistical analysis. Moreover, it is often of interest to identify unknown groups of units in a study population using such data structure, i.e., to perform clustering.
In the Bayesian framework, we propose a finite mixture of multivariate generalised linear mixed effects regression models to cluster numeric, binary, ordinal and categorical panel outcomes jointly. The specification of suitable priors on the model parameters allows for convenient posterior inference based on Markov chain Monte Carlo (MCMC) sampling with data augmentation. The Bayesian approach allows to obtain both a classification of the subjects in the data and new subjects as well as cluster-specific parameter estimates. Finally, model estimation and selection of the number of data clusters are simultaneously performed when approximating the posterior for a single model using MCMC sampling without resorting to multiple model estimations.
The performance of the proposed methodology is evaluated in a simulation study. Its application is illustrated on two data sets, one from a longitudinal patient study to infer prognosis groups, and a second one from the Czech part of the EU-SILC survey where households are annually interviewed to obtain insights into changes in their financial capability.
Case Serie of Hybrid Brachytherapy followed by Intensity Modulated Radiation Therapy (HyBIRT) Technique for the Definitive Management of Tongue Squamous Cell Carcinoma (TSCC)
Authors: Musa Muhamad Yusri , Appalanaido Gokula Kumar , Ch’ng Ewe Seng , Shukor Syadwa Abdul , Soon Eu Chong , Noor Siti Noor Fazliah Mohd , Azahari Ahmad Naqiuddin , Kamaruddin Siti Hajariah , Ishak Nor Hafizah , Aziz Mohd Zahri Abdul , Jalil Jasmin
Published: July 2022

Introduction
The Hybrid Brachytherapy followed by Intensity Modulated Radiation Therapy (HyBIRT) technique reverses the commonly used sequence by delivering high dose rate interstitial brachytherapy (HDRIBT) first followed by IMRT in the management of tongue squamous cell carcinomas (TSCC).
Materials and methods
Eleven patients treated with 20Gy in 5 fractions HDRIBT to TSCC followed by definitive IMRT to 69.96Gy to the involved nodes; 61.71Gy to the high risk volume and 56.1Gy to the low risk volume over 33 fractions in a single institution were analyzed retrospectively.
Results
All 11 patients achieved clinical complete response (cCR) and 9 patients with available radiological imaging achieved radiological complete response (rCR) at the primary site. One year locoregional progression-free survival was 90% (95% CI: 73.2% − 100%) and 18-month disease-free survival (DFS) for 8 patients who achieved rCR was 66.7% (95% CI: 30% − 100%). Median times to cCR and rCR at the primary site were 3.91 months and 4.34 months, respectively. Seven out of 8 patients with nodal disease achieved rCR of the nodes with a median time for rCR of 4.58 months. Two patients had persistent ulcer at 8 months and 11 months of follow-up.
Discussion
HyBIRT technique has the advantage of easy tumor identification during HDRIBT applicator insertion, ability to maneuver the subsequent IMRT plan and reduced the overall treatment time (OTT) while delivering tumoricidal dose to gross disease. Studies with larger sample size are needed to further confirm the efficacy of this organ sparring technique.
Single-Cell Transcriptomic and Chromatin Accessibility Atlas of Peripheral Blood Mononuclear Cells Reveal the Immune Cell Heterogeneity of Pigs
Authors: Bao Wenbin , Fan Hairui , Xu Chao , Du Cui , Wang Haifei , Wang Yuejun , Zhao Bin , Chen Chao , Shang Shaobin , Wu Shenglong , Sun Ming-an
Published: July 2022

Pig is a widely-used for biomedical studies and xenotransplantation, yet its immune cell heterogeneity remains poorly characterized. Here, we generate single-cell transcriptomes and chromatin maps for the Peripheral Blood Mononuclear Cells (PBMCs) of two porcine breeds with distinct immune traits. Dozens of cell types are annotated, with γδ T lymphocytes making up one-fifth of all PBMCs. Both the cellular composition and immune gene expression abundance underlie the immune trait variations across breeds. Transcription factors associated with each immune lineage are also identified, including many known to be critical for T, B and myeloid development. Furthermore, most cell populations and the corresponding markers match between pigs and human. Our study would be valuable not only for better understanding of the immune heterogeneity and immune traits in pigs, but also for identifying novel immune cell subsets, markers and regulators to facilitate future biomedical studies about human immunology and organ xenotransplantation.
Influencе of peptides from the bursa of Fabricius in broiler chickens on the functional activity of subpopulations of lymphocytes in immunosuppressed mice
Authors: Kolberg N. A. , Tikhonov S. L. , Tikhonova N. V. , Kudryashov L. S.
Published: July 2022

It is known that peptides inhibit the enzymes of viruses and are able to penetrate into cells by their embedding in the cell membrane, as a result of which the penetration of viruses into the host cell is blocked, which makes it possible to consider peptides as an alterna  tive to antiviral drugs. In this regard, the demand for immune-boosting nutraceuticals and functional foods containing biologically active peptides is growing. The immunomodulating effect of the peptides were studied on the mice of the BALb/c line that suffered from experimentally induced immunodeficiency; the mice got injections of peptides isolated from the bursa of Fabricius (bursal sac) of broiler chickens. 5 groups of BALb/c mice were formed. The animals of the 1st group (control one) received physiological saline per os as a placebo, animals of the 2nd group got bursal peptides per os at a dose of 0.02 mg/kg per body weight, the mice of 3rd group (immunosuppressed) got saline per os as a placebo, the 4th group (immunosuppressed) was administered the bursal peptides per os at a dose of 0.02 mg/kg of body weight, the 5th group was held as the control one (immunosuppressed group). Blood for tests was taken on days 1, 7 and 14 of the experiment. The functional activity of neutrophils was determined by the method of spontane  ous and induced chemiluminescence. Among the immudepressive animals (the 3rd group) on the 7th day the researchers observed a decrease in CD3+ by 55.3%, CD22+ by 83.7%, CD3+CD4+ by 51.9% and CD3+CD8+ by 54.6% in comparison with the intact (the 1st group). Administration of peptides to immunosuppressed mice (the 4th group) increases the number of subpopulations of CD3+ lymphocytes by 126.6%, CD22+ by 381.6%, CD3+CD4+ by 8.9% and CD3+CD8+ by 81.8% compared to immunosuppressed ani  mals, receiving saline per os as a placebo (group 3). Similar results were obtained on the 14th day of the experiment. On the basis of the performed studies, it can be argued that the immunocompetent organs of broiler chickens (bursa of Fabricius) are a promising source of immunotropic peptides.).
J. P. SARTRE FELSEFESİNDE VARLIĞIN FAZLADANLIĞI VE BULANTI DUYGUSU
Authors: GÜVENÇ Emel
Published: July 2022

Varoluşçuluk, bireye vurgu yapan, varoluş sorununa odaklanan, gelenekçi felsefeyi sığ bulan felsefelerin ortak adıdır. O nedenle tek bir varoluşçuluktan değil varoluşçu felsefelerden söz edilebilir. Önemli bir varoluşçu filozof olan Sartre’a göre yeryüzüne atılmış olumsal bir varlık olarak insan, fazladanlığının bilincine vardığında varoluşun saçmalığını idrak eder. Bu idrak onda bulantı hissi uyandırır. Sartre felsefesinde bulantı, özgürlüğünün farkına varan bireyin sorumluluklarının ağırlığıyla tecrübe ettiği bunaltı duygusundan farklı bir deneyimdir. Bulantı, olumsallığının bilincine varan bireyin hissettiği tiksinme duygusudur; boğucu bir sıkıntıdır; bir tür iç daralmasıdır. Bedeniyle kendinde varlık olan insan, bilinciyle kendisi için varlık olarak yeryüzünde bulantıyı tecrübe eder ve başkasıyla gerilimli bir ilişki içinde yaşar. Bu makalede Sartre’ın fenomenolojik ontolojisinin önemli kavramlarından olan kendinde varlık, kendisi için varlık kategorileri incelenmiş ve başkasının varoluşuna değinilmiştir; varlığın kökensel olumsallığı bağlamında ortaya çıkan fazladanlık bilincinin ve bulantı hissinin neliği üzerinde durulmuştur. Çalışmamızın amacını, Sartre’ın içeriklendirdiği şekliyle varlığın fazladanlığının ve bulantı duygusunun açıklanması oluşturmuştur.
Al-Mushkilāt fī al-Tamyīz bayna al-Tarkīb al-Iḍāfī wa-al-Tarkīb al-Naʿtī fī al-Qirā’ah li-Ṭalabat al-Jāmiʿah
Authors: Ramadlan M. ‘Athif Audl , Masngut Masngut
Published: July 2022

There are still many students in the Arabic Language Teaching Department at Walisongo State Islamic University Semarang who still face the difficulty of distinguishing between phrase and adjective structures in reading skill. There must be many reasons that cause difficulties and problems in distinguishing between phrase and adjective structures. The objectives of this research are: To find out the causes of problems in distinguishing between phrase and adjective structures in reading skill for students of the Arabic Language Teaching Department in 2017 at Walisongo State Islamic University Semarang and to know the appropriate solutions to overcome the problems. The researcher held a survey study with the statistical community of all students of the Arabic Language Teaching Department in 2017, with a number of 70 students. The researcher used the test and interview to collect data. The results of this research are that one of the reasons for its problems is the lack of control over the rules of auxiliary structure and the adjective structure and the differences between them, the lack of practice in determining the phrase and adjective structures and distinguishing between them in Arabic texts, the lack of practice in reading Arabic texts that contain the phrase and adjective structures, the lack of vocabulary, and the lack of understanding Vocabulary Genres. As for the solutions to the problems, they are supposed to the understand the rules of phrase and adjective structures and the differences between them, a lot of practice in identifying and differentiating between them in Arabic texts, more rehearsing in reading Arabic texts, a lot of reading Arabic texts so that students get a lot of vocabulary, and a lot of understanding the types of vocabulary.
Climate change impact on water balance and hydrological extremes in the Lower Mekong Basin: a case study of Prek Thnot River Basin, Cambodia
Authors: Ich Ilan , Sok Ty , Kaing Vinhteang , Try Sophal , Chan Ratboren , Oeurng Chantha
Published: July 2022

Climate change alters hydrological cycles and streamflow regimes at the local, regional and global levels. In this study, we aimed to assess the change in water balance change and hydrological extremes in the Prek Thnot River Basin of the Lower Mekong in Cambodia through a hydrological model (SWAT) under the two climate change scenarios (RCP2.6 and RCP8.5) following three different GCMs. An ensemble of 3 GCMs included GFDL-CM3, GISS-E2-R-CC and IPSL-CM5A-MR models and was applied to a well-calibrated SWAT model through climate change factors. Annual precipitation under RCP2.6 likely decreases by 0.1–0.5% for the near future (2021–2040) and mid-future (2051–2070) and decreases by 0.2–1.3% under RCP8.5. The decrease in precipitation will lead to reductions in water yield by 1–4% (RCP2.6) and 2–5% (RCP8.5). However, peak flow is expected to increase, while the low flow was projected to decrease (1–2% for RCP2.6 and 8–9% for RCP8.5). The study further found that high flow events will increase in both magnitude and frequency. The finding highlights water resources management issues in the Prek Thnot River Basin, including the frequency of future flood events.
The transform of Laplace, orthogonal transformations, moving fields
Authors: Pavlov Andrei Valerianovich
Published: July 2022

It is proved in article, that from point of numbers and new scalar work of diagonal of arbitrary rhombus it is possible to consider identical as a result of the orthogonal transformation, when lengths of vectors are measured in the same units of measuring as on sides of the rhombus. In the second part of article some class of functions is resulted: the values of the functions restore on the known positive values of the transform of Laplace. In the third part of article the examples are resulted, when a function of points of complex plane become periodic with the arbitrary period (from point of some introduction of two systems of co-ordinates).
Criança com diagnóstico de câncer sob cuidados paliativos e seu familiar: contribuições para o cuidado de enfermagem
Authors: Dias Lilian Laine da Conceição , Santos Larissa Christiny Amorim dos , Ribeiro Wanderson Alves , Fassarella Bruna Porath Azevedo , Alves Ana Lúcia Naves , Neves Keilado Carmo
Published: July 2022

O presente estudo consiste em uma revisão integrativa da literatura que viabiliza a compreensão do objetivo de levantar a produção científica sobre as ações de enfermagem nos cuidados paliativos junto a criança cm câncer e seu familiar e discutir os principais resultados e suas contribuições para o cuidado de enfermagem. O levantamento bibliográfico foi feito nas bases da Biblioteca Virtual de Saúde (BVS), sendo utilizado as bases de dados   Literatura Latino Americana e do Caribe em Ciências da saúde (LILACS), Scientific eletronic Library Online (Scielo) e a Base de Dados da Enfermagem (Bdenf). Através da revisão foi identificado algumas atuações de enfermagem, como ter um cuidado holístico, saber ouvir, ter um contato direto, tocá-la, proporcionar carinho, respeitar os sentimentos e saber proporcionar um ambiente onde esta criança se sinta acolhida, se sinta à vontade e tenha momentos de prazer, já que ela se encontra distante do seu cotidiano, longe do seu lar, da sua família, dos seus amigos, da sua escola, restrita ao lazer. Conclui-se que ter sensibilidade ao cuidar ainda é um grande desafio, pois existe uma grande esfera de pacientes onde a enfermagem tem dificuldade de proporcionar um suporte emocional mais completo e adequando. Ou no caso de uma criança com câncer esse emocional, pode estar mais exacerbado, o que pode alterar a rotina e os sentimentos desse profissional. Tais reflexões podem ser temas de futuros trabalhos e trazer novos subsídios para a assistência a esses pacientes.
Descritores: Enfermagem Pediátrica; Câncer Infantil, Cuidado de Enfermagem; Cuidado Paliativo.
Fractional solution of helical motion of a charged particle under the influence of Lorentz force
Authors:   Department of Physics, Mutah University, Mutah, Jordan, Altarawneh Moaz Mohammad
Published: July 2022

In this study, a generalized solution for the helical motion of a charged particle in uniform electric and magnetic fields is obtained using a powerful fractional derivative approach. Using this approach, the differential equations that describe the helical motion of a charged particle in the fields were obtained. The solution for the fractional differential equations is presented in great detail in terms of a series solution using the Mittag-Leffler function. The Laplace transform technique was used to solve the differential equations in the regular form and in the fractional form (with fractional parameter γ). Two and three-dimensional plots were presented for the trajectory of the particle before and after introducing the fractional operator for different values of γ. Features of delay in the motion and dissipation in the medium have been observed in the fractional solution too. The importance of our work stems from the two- and three-dimensional visualization of the obtained generalized helical trajectories that can be applied to similar types of motions in nature and the universe.
Co-created Technological Solutions for Caregivers in Health Care: Systematic Review (Preprint)
Authors: Merchán-Baeza Jose Antonio , Borralleras Andreu Cristina , Minobes-Molina Eduard , Grau Carrión Sergi , Romero-Mas Montse , Ramon-Aribau Anna
Published: July 2022

BACKGROUND

Support interventions for caregivers can reduce their stress, possibly improving the quality of patients’ care while reducing care costs. Technological solutions have been designed to cover their needs, but there are some challenges in making them truly functional for end users. Co-design approaches present important opportunities for engaging diverse populations to help ensure that technological solutions are inclusive and accessible.

OBJECTIVE

This study aimed to identify co-created technological solutions, as well as the process followed for their co-creation, in the field of health for caregivers.

METHODS

The literature review was conducted in the Medline, Web of Science, Scopus, Science Direct, Scielo, and IEEE Xplore databases. The inclusion criteria were studies written in English or Spanish and with a publication date until May 2021. The content had to specify that the caregivers actively participated in the co-creation process, which covered until the development phase of the technological solution (prototype). The level of evidence and the methodological quality were analyzed when possible, using the Scottish Intercollegiate Guidelines Network criteria and the Mixed Methods Appraisal Tool, version 2018, respectively.

RESULTS

In total, 410 papers were identified, and 11 met the eligibility criteria. The most predominant articles were mixed methods studies and qualitative studies. The technology used in the analyzed articles were mobile or web applications (9 studies) and specific devices such as sensors, cameras, or alarm systems (2 studies) to support the health and social aspects of caregivers and improve their education in care. The most common patient profile was older people (7 studies); 6 studies used co-creation in the requirements phase, 6 studies detailed the design phase. In 9 studies, the prototype was iteratively refined in the development phase, and the validation phase was performed in 5 of the reviewed studies.

CONCLUSIONS

This systematic review suggests that existing co-created technological solutions in the field of health for caregivers are mostly mobile or web applications to support caregivers’ social health and well-being and improve their health knowledge when delivering care to patients, especially older people. As for the co-creation process, caregivers are particularly involved during development and in the design. The scarce literature found indicates that further research with higher methodological quality is needed.

CLINICALTRIAL
Mutu Fisik Buah Salak Pondoh (Salacca edulis Reinw): Pengaruh Pelilinan dan Pengemasan Menggunakan Kantong Plastik Low Density Polyethylene
Authors: Djaafar Titiek Farianti , Marwati Tri , Indrasari Siti Dewi , Hatmi Retno Utami , Siswanto Nugroho , Purwaningsih Purwaningsih , Ambarsari Indrie , Supriyadi Supriyadi
Published: July 2022

Salak Pondoh (Salacca edulis Reinw) merupakan komoditi unggulan Yogyakarta, khususnya Kabupaten Sleman. Buah salak Pondoh telah diekspor ke beberapa Negara. Penelitian ini bertujuan untuk mempelajari pengaruh pelilinan dan kemasan individu salak Pondoh menggunakan plastik Low Density Polyethylene (LDPE). Lima perlakuan pelilinan dan pengemasan, yaitu pengemasan individu buah (kantong LDPE) dengan pengemasan sekunder (kotak karton berlubang) (A), pengemasan individu buah (kantong LDPE) dengan pengemasan sekunder (keranjang plastik) (B), pelilinan dengan penambahan ekstrak lengkuas 5% dengan pengemasan sekunder (keranjang plastik) (C), pengemasan sekunder (keranjang plastik) (D), dan pengemasan dengan kotak karton berlubang (E). Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap dengan ulangan sebanyak 3 kali. Hasil penelitian menunjukkan bahwa penggunaan kantong LDPE dengan kemasan sekunder keranjang plastik maupun karton berpengaruh positif dalam menurunkan susut bobot, mempertahankan tekstur dan warna daging buah. Pelilinan dengan penambahan ekstrak lengkuas 5% berpengaruh negatif pada penurunan susut bobot, mempertahankan kekerasan (tekstur) dan warna daging buah. Penggunaan kantong LDPE untuk pengemasan buah salak dapat mempertahankan umur simpan sampai hari ke-30 dengan susut bobot di bawah <10%.
Relationship of Family Function to the Quality of Life of Persons with Disabilities
Authors: Susanti Budi , Claramita Mora , Istiono Wahyudi
Published: July 2022

Background: People with disabilities are often referred to as disabled people, and regarded as unproductive members of society, unable to perform their duties and responsibilities so that their rights are sometimes not protected and violated. The number of persons with disabilities is about 15% of the world population, with 2.45% in Central Java and 0.75% in Purworejo Regency. Many people with disabilities need family attention. As a direct result, family has an important role in improving the quality of life of persons with disabilities. Assessment of family function using the family APGAR score and the quality of life of persons with disabilities using the WHOQOL-BREF instrument can be performed by most family doctors. Objective: This research aimed to determine the relationship of family function in people with disabilities using Family APGAR scores and quality of life using the WHOQOL-BREF instrument. Methods: This research was a quantitative analytical study with a cross-sectional design. Out of a total of 535 people with disabilities as research subjects and respondents, 190 people were excluded and 345 respondents were included. Statistical analysis used Spearman correlation tests to determine the relationship between the quality of family function and quality of life. Data processing used the Syntax program with significance set as p<0.05. Results: Data collection in 29 villages that became the locations of the study obtained 345 samples. Statistical analysis results showed significant associations of APGAR score, sex and age with WHOQOL-BREF measurement (p=0.00). The family function had a significant relationship with the quality of life in the domain of social and environmental relations. Conclusion: There is a relationship between family function and the quality of life of persons with disabilities in the domain of social and environmental relations.
Energy and basic reproduction number of n-Corona graphs prior to order 1
Authors: Vivik J. Veninstine
Published: July 2022

This paper advances the corona product to n times corona in the aspect of increasing and decreasing product of graphs and calibrates its energy and basic reproduction number. The proposed model emanates as a graph with successive generations of complexity, whose structure is constructed as a matrix based on its adjacency. The energy is measured from the sum of the absolute values of the eigenvalues of the adjacency matrix of graph G and the largest eigenvalue is known to be R0. The energy upper bound for increasing and decreasing n-corona product with order 1 of complete graphs are attained.
Reformismo borbónico y educación. El Colegio de San Ildefonso y sus colegiales (1768-1816)
Authors: Hidalgo Pego Mónica
Published: July 2022

Este libro analiza las reformas introducidas en el Colegio de San Ildefonso en cuatro aspectos básicos: gobierno, financiamiento, saberes y beneficiarios. Los cambios convirtieron al colegio en una institución compleja y jerarquizada; fiel reflejo de ello fue la coexistencia de diferentes grupos de colegiales con características, cualidades y privilegios distintos o la apertura de aulas para el estudio que lo trasformaron en un colegio de pleno ejercicio o de enseñanza. San Ildefonso fue un digno representante de los cambios educativos orquestados desde el poder.
Personalized Book Recommendation System using TF-IDF and KNN Hybrid
Authors: S Rashika
Published: July 2022

Abstract: A recommendation system helps an organization to create loyal customers and build trust by offering their desired products and services. These systems today are so powerful that they can handle the new customer too who has visited the site for the first time. With the increasing number of books, people prefer to use e-books. Today, online businesses have emerged that are dedicated only for e-books. They allow their users to purchase any books of their interest or even read them online. This improves their business targets. To make their users engaged, they use machine learning models that recommend users the books based on their preferences. Such a system is called Book Recommendation System. Over the past, a large number of book recommendation systems have been built, most of them are found to be useful for both the organization and the users, and are being put into use in the real world. In this proposed system, we build a Book Recommendation System which recommends a set of books to users based on their previous ratings and readings using content-based filtering, collaborative filtering, and hybrid filtering model. This will save users time in searching the books of their interest.
Review of Database Management Systems and Their Categories with Use Cases
Authors: Kumar Raman
Published: July 2022

Abstract: Data has become very important in today’s world for industries, education and research, healthcare, and many different services. With the advancements in technologies and tools, data can be preserved and manipulated to draw meaningful conclusions and accomplish tasks. The database management systems provide the platform to store and manage the data and thus perform the expected tasks efficiently. In the paper, popularly used databases are reviewed for the features and the use case scenarios are identified for application. Five common Database management systems categories namely, document store, spatial, graph, search engine and time series database management systems are reviewed with the types of data that has to be stored in that category.
Programming in OpenCL and its advantages in a GPU Framework
Authors: Harshavardhan K S
Published: July 2022

Abstract: OpenCL is a framework used for building applications that mostly run on heterogenous platforms containing CPUs, GPUs, and DSPs. OpenCL provides an interface for parallel programming that can be used to take advantage of the GPUs high parallel computing power. Programmers who need complete control over the parallelization process and who are required to write portable heterogeneous code mostly use OpenCL. OpenCL views a processing unit as a collection of compute units which in turn are made up work items. According to OpenCL’s workflow and memory hierarchy, each work item is a thread as far in terms of control and memory model. A collection of work items is called a work group which is mapped to a compute unit. The language used to write “compute kernels” is called kernel language. OpenCL uses C/C++ to carry over the kernel computations done on the device. The host code specifies the kernel specifications that is needed for the computation of the device which includes creating buffers, calling kernels, mapping the memory back to CPU from device, etc. OpenCL also has specific optimization techniques that helps improve parallelization while computing on a GPU which results in better performance numbers
Review on Iris Recognition Research Directions- A Brief Study
Authors: M R Dr. Lokesh
Published: July 2022

Abstract : Biometric methods, which identify people based on physical or behavioral characteristics, are of interest because people cannot forget or lose their physical characteristics in the way that they can lose passwords or identity cards. Among these biometric methods, iris is currently considered as one of the most reliable biometrics because of its unique texture‘s random variation. It is found that this method for Iris Recognition design offers good class discriminacy. The iris recognition technique consists of iris localization, normalization, encoding and comparison. The Neural Classifier will be a feed forward network with three hidden layers and be used after normalization and feature extraction phase. Simulation results will be very promising in person identification.
Evaluation of the Health Impacts of PM2.5 (Stroke, IHD, LRI)
Authors: Srivastav Ankeshit
Published: July 2022

Abstract: In this study, an attempt has been made to determine the human health risk due to exposure to PM2.5 in the State of Uttar Pradesh during the years 2017, 2018, and 2019. The values of Burden of Disease for the respective years and location were taken from the Global Burden of Disease (GBD) Portal. The Relative Risk is calculated using the AIRQ+ software from which Population Attributable Fraction was estimated. We got the Mortality by using the values of Attributable Burden of Disease. From which we came the results that the values of relative risk (central) for Stroke for the years 2017, 2018, and 2019 are 1.436, 1.429, and 1.388 respectively, and the relative risk for Ischemic Heart Disease (IHD) is 1.522, 1.528, and 1.646 for the year 2017, 2018 and 2019 respectively and the values for relative risk for LRI for the year 2017, 2018, and 2019 is 1.825, 1.815 and 1.701 respectively.
Reconstruction of Gene Regulatory Network for Colon Cancer Dataset
Authors: Bhyratae Suhas A
Published: July 2022

Abstract: Molecular networks involve interacting proteins, RNA, and DNA molecules, which underlie the major functions of living cells. DNA microarray probes how the gene expression changes to perform complex coordinated tasks in adaptation to a changing environment at a genome-wide scale. Microarray is a technology that has been widely used to probe the presence of genes in a sample of DNA or RNA. This technology helps to check the expression levels of thousands of genes together. The DNA microarray was established as a tool for the efficient collection of mRNA expression for a large number of genes. The mapping function route maps pairs of genes that present similar positive, and negative interactions and also defines how the range of each gene is going to be segmented. From all the combinations a function transforms each pair of labels into another one that classifies the type of interaction. This project addresses the challenge of reconstructing molecular networks and gene regulation from gene expression data. Reconstruction of gene regulatory networks which can also be called reverse engineering is a process of identifying gene interaction networks from the experimental microarray gene expression profiles through computation techniques. The main features involved in the computation of interaction in the filtered genes are the discretization mapping function, gene-gene mapping function, and filtering function.
Stream Processing for Association Rule to Generate Student Dataset using Apriori Algorithm
Authors: Ghodke Keerti
Published: July 2022

Abstract: Analytical techniques have been used for many years to analyse and predict academic achievement from various perspectives. One of the most challenging problems for higher education is predicting students' paths through the education system. Many factors influence successful student outcome prediction in the early course stage. Apriori algorithm techniques use a variety of methods to find out and collect based on stored data patterns student information. Colab and Python applications are used in this project to predict each student based on characteristics in the given dataset. Each student's information is included in the dataset. Because it arrives as it is being created, received real-world data is referred to that as streaming data.
The Manoeuvring of ERP in Education
Authors: Shamma Aashitha L
Published: July 2022

Abstract: The goal of this project is to raise productivity levels in the installation of enterprise resource planning (ERP) software, notably in the educational sector. In order to do this, it was determined what factors related to benefits sought through the use of ERP systems and what crucial criteria underpinned successful ERP deployment. An institutional enterprise resource product that will connect all the departments within the institution, including academics, finance, administrative, communication, and information; contribute to the automation process; provide a dashboard for the institution; allow for the payment of fees and the keeping of logs; and have a better user interface and multi-platform usability (web & android) Android app. ERP college web applications are the only web applications that combine all of the modules and features of the college system that the administrative head may manage and students and faculty can access with a legitimate user ID and password. The project's goal is to provide a solid interface that allows educational institutions to easily and quickly handle all of their workflows, from students, preceptors, and management to all notices. Even in virtual mode, it will enable better security and stable operation. This can be particularly useful when there is a pandemic. If done with sophisticated intelligence, it might even assist the institutions in identifying management weak points or transmit its information back to top level board for development and general organizational well-being, assisting it in fulfilling its true mission.
A review on Buffer Chips and growing Memory Bandwidths
Authors: Y Manoj
Published: July 2022

Abstract: The rapid development of CPU technology and the increase in the number of functionalities involved in a chip demand improvement in the memory bandwidth to feed data to the growing pipeline technology. Slower memory bandwidth would result in reduced CPU utilization and make the processor stay idle. The rise in memory bandwidth comes with the challenge of maintaining the signal integrity and affects the number of DIMM (Dual Inline Memory Module) slots in a channel and reduces memory capacity. The challenge of maintaining the signal integrity with the increase in the frequency of operation is solved by introducing additional interfacing chips between the memory controller or CPU and memory module. Buffer chips are used in servers to maintain signal integrity and meet the timing parameters for the commands and addresses sent to the memory modules. Buffer chips help in increasing the frequency of operations as well as the number of memory modules connected. Register Clock Driver (RCD) is one buffer chip used between the memory controller and DRAM that supports the bandwidth and capacity needed in the next-generation data centres. This paper aims at reviewing importance of buffer chips and their application in modern day data centres.
A Study on Air Pollution Exposure on Commuters in Jaipur
Authors: Mandal Priyanka
Published: July 2022

Abstract: One of the most important challenges that are escalating in emerging nations like India is air pollution. Motor vehicle usage has significantly increased as a result of rapid development of India. Ninety percent of all emissions are contributed by the transportation sector. A major environmental health risk to people is air pollution. The negative effects might include anything from nausea, breathing problems, skin rashes, birth defects, immunodeficiency, and cancer. Air pollutants can seriously impair a person's health if they are exposed to them for a lengthy period of time, therefore it is common for people to endure unpleasant travel situations and alter their travel plans, destinations, or modes of transportation. The present study is a case study of an increase in vehicular pollution in Jaipur, capital of Rajasthan which is one of the highly polluted cities in state.
DAMPAK EKOWISATA TERHADAP KESEJAHTERAAN MASYARAKAT DI KAWASAN WISATA AIR TERJUN KOTA BATU
Authors: Permono Eki , Boedirochminarni Arfida , Wahyudi M.Sri
Published: July 2022

This study had a objective, that is : to analyze about fover the fuction of forest and the walfare in tourist area of Batu waterfall so it can be known are over the forest fuction commensurate with the well being og obtained by local communities. Analysis tools used are descriptive quantitative  using t-test, the results of this study showed people's income are changed, this can be seen from the average revenue of the society. Where the average income is Rp 770.000 growing up 77.99% to Rp 1,355,000. The social impact is assessed of changes in the quality and means of education. Improvement of facilities and quality of this became the catalyst so that the public send his son. Healthy life patterns society became better as well as the existence of a new business field that makes labor can be absorbed around the tourist areas. The negative impact of any missed over the function of the forest, that is because of the numbers of visitors to much adn resulted in noise at citizens when entering the rest time.Keywords : environmental impact, Batu waterfall, revenue, social impact, tourist development
ANALISIS PENDAPATAN INDUSTRI MEBEL DI KELURAHAN TUNJUNGSEKAR KECAMATAN LOWOKWARU KOTA MALANG
Authors: Kristian Natalia Popy , Zuhroh Idah , Susilowati Dwi
Published: July 2022

This study aims to investigate the characterictics of furniture industry, effect of capital, wages, and long effort towards income of furniture industry in Malang. In this study, researcher uses 30 respondents of stakeholders. The data type used is a cross-section then do hypothesis testing with F-test, t-test, and the coefficient of Determination on error rate α=5%. Furthermore, in this study also analyze cost efficiency and income. The findings of this study shows that capital variable has not significant effect towards income. Whereas, other variable such as wages and long effort have significant impact on the income of furniture industry in Malang. However, simultaneosly capital, wages, and long effort have significant impact. While the value of the coefficient of determination (R2) is 0,48, this indicates the ability of capital variable, wages, and long effort in explaining the amount of income of 48%. In addition, the cost of furniture industry in Malang is quite efficient and has average income 35,7 million.
ANALISIS SEKTOR EKONOMI UNGGULAN DAN PERGESERAN STRUKTUR PEREKONOMIAN KOTA BATU TAHUN 2012-2016
Authors: Silvya Nadya Bella , Hidayat Wahyu , Syaifullah Yunan
Published: July 2022

Economic development must include economic growth, where economic development greatly encourages economic growth and economic growth facilitates the process of economic development. With this to know the leading economic sectors in the economy in Batu City in 2012-2016. By using analysis tools Merging Static Location Quotient (SLQ) and Dynamic Location Quotient (DLQ), Klassen Typologies and Shift-Share.The research results obtained that in Batu City based on the analysis of the Merger of Static Location Quotient (SLQ) and Dynamic Location Quotient (DLQ) belonging to the superior economic sector is the economic sector of Construction. The Klassen Typology analysis, which is classified as a fast-developing and fast-growing sector, is the Construction, Large and Retail Trade sector; Reparas for Cars and Motorbikes, Provision of Accommodation and Food Drinking,   Information and Communication, and Other Services. While, the Shift-Share analysis which is classified as capable of competing or competitive is the sector of Large Trade and Retail; Repair of Cars and Motorbikes, Provision of Accommodation and Food Drinking, and Construction.
DETERMINAN PENGGELAPAN PAJAK (TAX EVASION) DENGAN RELIGIUSITAS SEBAGAI VARIABEL PEMODERASI
Authors: Jamalallail Ulfa Fauzi , Indarti Maria Goreti Kentris
Published: July 2022

Tujuan pene1itian ini ada1ah untuk menguji pengaruh machiave11ian, 1ove of money, sanksi perpajakan dan se1f assessment system terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion) dengan re1igiusitas sebagai variabe1 moderasi. Popu1asi yang digunakan da1am pene1itian ini ada1ah wajib pajak orang pribadi yang terdaftar di KPP Pratama Semarang Barat tahun 2020 sebanyak 38.891 wajib pajak  orang pribadi. Jum1ah sampe1 da1am pene1itian ini ada1ah sebanyak 100 wajib pajak orang pribadi. Metode pene1itian  menggunakan regresi 1inier berganda. Hasi1 ana1isis menunjukkan bahwa machiave11ian  berpengaruh positif terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Love of money berpengaruh positif terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Sanksi perpajakan tidak berpengaruh terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Se1f assessment system tidak berpengaruh terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh machiave11ian terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh 1ove of money terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh sanksi perpajakan terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion). Re1igiusitas mampu memoderasi pengaruh se1f assessment system  terhadap persepsi wajib pajak mengenai pengge1apan pajak (tax evasion).
In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum
Authors: Prawesty Diah Utami  , Febrianti Zuhro Putri Febrianti
Published: July 2022

Abstract

                Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose uses the biota because many reports that there is a failure of malaria treatment therapy due to Artemisinin-based Combination Therapy (ACT) resistance. The purpose of this study was to find out the antimalarial activity of Holothuria atra extract with ethyl acetate solvent at dose 0.01; 0.1; 1; 10; and 100 Ug/ml against Plasmodium falciparum in vitro. Extract lollyfish using the maceration method. The lollyfish powder will be dissolved with ethyl acetate solvent for 24 hours. Antimalarial activity testing is measured through 4 parameters, namely the measurement of parasitemia rates, % parasite growth, % inhibitory rate, and IC50. Antimalarial activity with ethyl acetate solvent belongs to a very active category with an IC50 value of 1.52 µg/mL. These results can kill the P. falciparum parasite with a percentage that reaches 0%. A decrease in the percentage of growth occurs when the dose given is too low so that the parasite can grow and survive. The result of higher concentrations of extracts will have a higher percentage of resistance to the growth of parasites. The potential for antimalarial activity in lollyfish extract is influenced by the presence of active content such as alkaloids, flavonoids, catechins, and pyrogallol owned by marine biota animals. This study suggests that lollyfish (H. atra) can be developed as an alternative treatment for malaria.

Keywords: Holothuria atra, antimalarial, Plasmodium falciparum, in vitro