bluuebunny/crossref_metadata_2025 huggingface dataset:
Negative emotions and their management in Chinese convalescent cervical cancer patients: a qualitative study
Authors: Ji Juan , Zhu Hui , Zhao Ju-zhen , Yang Yi-qun , Xu Xiao-ting , Qian Ke-yan
Published: September 2020

Objective

The aim of the study was to understand the experience of negative emotions and coping styles of patients with cervical cancer during the rehabilitation period.

Methods

A descriptive qualitative research method was used. Purposive sampling was used to recruit participants. Semi-structured interviews were conducted with 18 cervical cancer patients and the data were analysed using content analysis.

Results

The analysis identified three relevant themes. Theme 1: Negative emotions in convalescent cervical cancer patients mainly comprised fear of recurrence, worries about sex and feelings of inferiority. Theme 2: Patients used positive and negative coping styles to manage negative emotions. Theme 3: Patients expressed a strong need for rehabilitation information.

Conclusions

Patients with cervical cancer exhibited negative emotions during the rehabilitation period. To help these patients, medical staff should develop an understanding of their needs by communicating more with patients and providing them with targeted care to help them return to society more quickly.
Transcriptome sequencing identifies genes associated with invasion of ovarian cancer
Authors: Peng Xiandong , Yu Min , Chen Jiazhou
Published: September 2020

Objective

To identify key genes in ovarian cancer using transcriptome sequencing in two cell lines: MCV152 (benign ovarian epithelial tumour) and SKOV-3 (ovarian serous carcinoma).

Methods

Differentially expressed genes (DEGs) between SKOV-3 and MCV152 were identified. Candidate genes were assessed for enrichment in gene ontology function and Kyoto Encyclopaedia of Genes and Genomes pathway. Candidate gene expression in SKOV-3 and MCV152 cells was validated using Western blots.

Results

A total of 2020 upregulated and 1673 downregulated DEGs between SKOV3 and MCV152 cells were identified that were significantly enriched in the cell adhesion function. Upregulated DEGs, such as angiopoietin 2 ( ANGPT2), CD19 molecule ( CD19), collagen type IV alpha 3 chain ( COL4A3), fibroblast growth factor 18 ( FGF18), integrin subunit beta 4 ( ITGB4), integrin subunit beta 8 ( ITGB8), laminin subunit alpha 3 ( LAMA3), laminin subunit gamma 2 ( LAMC2), protein phosphatase 2 regulatory subunit Bgamma ( PPP2R2C) and spleen associated tyrosine kinase ( SYK) were significantly involved in the extracellular matrix-receptor interaction pathway. Downregulated DEGs, such as AKT serine/threonine kinase 3 ( AKT3), collagen type VI alpha 1 chain ( COL6A1), colony stimulating factor 3 ( CSF3), fibroblast growth factor 1 ( FGF1), integrin subunit alpha 2 ( ITGA2), integrin subunit alpha 11 ( ITGA11), MYB proto-oncogene, transcription factor ( MYB), phosphoenolpyruvate carboxykinase 2, mitochondrial ( PCK2), placental growth factor ( PGF), phosphoinositide-3-kinase adaptor protein 1 ( PIK3AP1), serum/glucocorticoid regulated kinase 1 ( SGK1), toll like receptor 4 ( TLR4) and tumour protein p53 ( TP53) were involved in PI3K-Akt signalling. Expression of these DEGs was confirmed by Western blot analyses.

Conclusion

Candidate genes enriched in cell adhesion, extracellular matrix–receptor interaction and PI3K-Akt signalling pathways were identified that may be closely associated with ovarian cancer invasion and potential targets for ovarian cancer treatment.
Improving Traffic Flow Efficiency at Motorway Lane Drops by Influencing Lateral Flows
Authors: Subraveti Hari Hara Sharan Nagalur , Knoop Victor L. , van Arem Bart
Published: September 2020

Lane drops are a common bottleneck source on motorway networks. Congestion sets in upstream of a lane drop as a result of the lane changing activity of merging vehicles. This causes the queue discharge rate at the bottleneck to decrease and drop below the capacity, leading to capacity drop and further congestion. The objective of this study is to minimize the total travel time of the system by controlling lateral flows upstream of the lane drop. This is equivalent to maximizing the exit flows at the bottleneck. An optimization problem is formulated for a 3–2 lane drop section with high inflow. The problem is solved for different test cases where the direction of lateral flows being controlled is varied. An incentive based macroscopic model representing the natural lane changing scenario is used as a benchmark for comparison. The results showed that by influencing the lateral flows upstream of the bottleneck, the queue discharge rate increased by more than 4.5%. The total travel time of the system was consequently found to be reduced. The improvements in performance were primarily a result of the distribution of lane changing activity over space and the balancing of flow among the lanes which lead to the decrease in the severity of congestion. The findings reveal a potentially effective way to reduce the severity of congestion upstream of lane drop bottlenecks during high demand which could be implemented using roadside and in-car advisory systems.
The Effect of Resection Size in the Treatment of Cam-Type Femoroacetabular Impingement in the Typical Patient With Hip Arthroscopy: A Biomechanical Analysis
Authors: Bonano John C. , Johannsen Adam , Mardones Rodrigo M. , Fithian Andrew , Storaci Hunter , Tam Kaysie , Safran Marc R.
Published: September 2020

Background:

Arthroscopic osteochondroplasty may improve range of motion and relieve pain in patients with symptomatic hip impingement. Femoral neck fracture is a risk of this procedure because of the weakening of the proximal femur. To our knowledge, there are no biomechanical studies in young human cadaveric bone evaluating the effect of osteochondroplasty on femoral neck strength.

Purpose/Hypothesis:

The purpose was to evaluate loads to fracture in young human cadavers after resection depths of 25% and 40% at the head-neck junction. We hypothesized that both depths will maintain ultimate loads to failure above previously published loads, as well as above physiologic weightbearing loads.

Study Design:

Descriptive laboratory study.

Methods:

Cadaveric proximal femoral specimens (6 matched pairs, under the age of 47 years) were divided into 2 groups: 25% or 40% of the diameter at the head-neck junction was resected. The length of the resection was 2 cm and the width of the resection was determined by the length of the anterolateral quadrant at the head-neck junction in all cases. A compressive load was applied directly to the femoral head. Peak load, stiffness, and energy to fracture were compared between groups.

Results:

The average peak load to fracture after 25% resection (7347 N) was significantly higher than after the 40% resection (5892 N) ( P = .010). The average energy to fracture was also significantly higher in the 25% resection group (30.2 J vs 19.2 J; P = .007). The average stiffness was higher in the 25% group, although not statistically significant ( P = .737).

Conclusion:

Resection depths of 25% and 40% at the anterolateral quadrant of the femoral head-neck junction may be safe at previously described functional loads such as standing and walking in the age range more typically seen in patients undergoing hip arthroscopy. Loads to fracture were significantly higher than previously reported using older cadaveric specimens.

Clinical Relevance:

Currently, most surgeons limit weightbearing after femoral osteochondroplasty in part because of risk of femoral neck fracture. Given the higher observed loads to fracture, young patients could possibly bear weight sooner after surgery, although postoperative protocols should be individualized based on patient age, weight, bone density, amount of bone resected, concomitant procedures, and potential compliance with activity restrictions.
Primary Care and Access to Mental Health Consultations among Immigrants and Nonimmigrants with Mood or Anxiety Disorders: Soins de première ligne et accès aux consultations en santé mentale chez les immigrants et les non-immigrants souffrant de troubles de l’humeur ou anxieux
Authors: Rivera Joanna Marie B. , Puyat Joseph H. , Wiedmeyer Mei-ling , Lavergne M. Ruth
Published: September 2020

Objective:

To examine the association between usual place of primary care and mental health consultation among those with self-reported mood or anxiety disorders. We also describe access to mental health services among people who are recent immigrants, longer-term immigrants, and nonimmigrants and determine whether the association with place of primary care differs by immigration group.

Methods:

We used data from the Canadian Community Health Survey (2015 to 2016) to identify a representative sample of individuals with self-reported mood or anxiety disorders. We used logistic regression, with models stratified by immigration group (recent, longer-term, nonimmigrant), to examine the association between usual place of primary care and receiving a mental health consultation in the previous 12 months.

Results:

Higher percentages of recent and longer-term immigrants see a doctor in solo practice, and a higher percentage of recent immigrants use walk-in clinics as a usual place of care. Compared with people whose usual place of care was a community health center or interdisciplinary team, adjusted odds of a mental health consultation were significantly lower for people whose usual place of care was a solo practice doctor’s office (AOR = 0.71; 95% CI, 0.62 to 0.82), a walk-in clinic (AOR = 0.75; 95% CI, 0.66 to 0.85), outpatient clinic/other place (AOR = 0.72 95% CI, 0.59 to 0.88), and lowest among people reporting no usual place other than the emergency room (AOR = 0.59; 95% CI, 0.51 to 0.67). Differences in access to mental health consultations by usual place of primary care were greatest among immigrants, especially recent immigrants.

Conclusions:

People with mood or anxiety disorders who have access to team-based primary care are more likely to report mental health consultations, and this is especially true for immigrants. Expanded access to team-based primary health care may help reduce barriers to mental health services, especially among immigrants.
The Algorithmic University: On-Line Education, Learning Management Systems, and the Struggle over Academic Labor
Authors: Ovetz Robert
Published: September 2020

The use of on-line education (OLE) to deliver higher education using learning management systems (LMS) has received growing critical attention for its reliance on precarious faculty, high dropout and failure rates, and as a form of privatization. While these critiques are well grounded, they overlook the role of OLE as a strategy for rationalizing teaching and deskilling academic labor in order to produce more self-disciplined precarious “platform” workers who can labor remotely under the control of algorithmic management. To recompose the power of academic workers, new tactics, strategies, and objectives based on an analysis of the new technical composition of capital in higher education are needed.
Modulation of T-Cell Activation Markers Expression by the Adipose Tissue–Derived Mesenchymal Stem Cells of Patients with Rheumatic Diseases
Authors: Kuca-Warnawin Ewa , Janicka Iwona , Szczęsny Piotr , Olesińska Marzena , Bonek Krzysztof , Głuszko Piotr , Kontny Ewa
Published: September 2020

Background:

Activated T lymphocytes play an important role in the pathogenesis of rheumatic diseases (RD). Mesenchymal stem cells (MSCs) possess immunoregulatory activities but such functions of MSCs from bone marrow of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and ankylosing spondylitis (AS) patients are impaired. Adipose tissue–derived MSCs (ASCs) are an optional pool of therapeutically useful MSCs, but biology of these cells in RD is poorly known. This study aimed at investigating the effect of ASCs from RD patients and healthy donors (HD) on the expression of the key T-cell activation markers.

Methods:

ASCs were isolated from subcutaneous abdominal fat from SLE ( n = 16), SSc ( n = 18), and AS ( n = 16) patients, while five human ASCs lines from HD were used as a control. Untreated and cytokine (tumor necrosis factor α + interferon γ)-treated ASCs were co-cultured with allogenic, mitogen (phytohemagglutinin)-stimulated peripheral blood mononuclear cells (PBMCs) or purified anti-CD3/CD28-activated CD4+T lymphocytes. Contacting and noncontacting ASCs-PBMCs co-cultures were performed. RD/ASCs were analyzed in co-cultures with both allogeneic and autologous PBMCs. Flow cytometry analysis was used to evaluate expression of CD25, HLA-DR, and CD69 molecules on CD4+and CD8+cells.

Results:

In co-cultures with allogeneic, activated CD4+T cells and PBMCs, HD/ASCs and RD/ASCs downregulated CD25 and HLA-DR, while upregulated CD69 molecules expression on both CD4+and CD8+cells with comparable potency. This modulatory effect was similar in contacting and noncontacting co-cultures. RD/ASCs exerted weaker inhibitory effect on CD25 expression on autologous than allogeneic CD4+and CD8+T cells.

Conclusion:

RD/ASCs retain normal capability to regulate expression of activation markers on allogeneic T cells. Both HD/ASCs and RD/ASCs exert this effect independently of their activation status, mostly through the indirect pathway and soluble factors. However, autologous CD4+and CD8+T cells are partially resistant to RD/ASCs inhibition of CD25 expression, suggesting weaker control of T-cell activation in vivo.
Neuroscience and the Social Origins of Moral Behavior: How Neural Underpinnings of Social Categorization and Conformity Affect Everyday Moral and Immoral Behavior
Authors: Ellemers Naomi , van Nunspeet Félice
Published: September 2020

Neuroscientific evidence identifies the brain networks and cognitive processes involved in people’s thoughts and feelings about their behavior. This helps individuals understand the judgments and decisions they make with regard to their own and others’ moral and immoral behavior. This article complements prior reviews by focusing on the social origins of everyday moral and immoral behavior and reviewing neuroscientific research findings related to social conformity, categorization, and identification to demonstrate (a) when people are motivated by social norms of others to follow particular moral guidelines, (b) what prevents people from considering the moral implications of their actions for others, and (c) how people process feedback they receive from others about the appropriateness of their behavior. Revealing the neural mechanisms involved in the social processes that influence the moral and immoral behaviors people display helps researchers understand why and when different types of interventions aiming to regulate moral behavior are likely to be successful or unsuccessful.
Learning to Write Words
Authors: Treiman Rebecca
Published: September 2020

Learning to produce the written forms of individual words is an important part of writing. In this article, I review research on how children acquire this skill. I begin by discussing young children’s knowledge about the visual appearance of writing and then consider how learners of alphabetic writing systems begin to use letters to symbolize the sounds they hear in words. The English writing system, the focus of this review, is complex. In the final section of the article, I discuss how older children learn about its subtler patterns. Implications of the research for how children learn and for how spelling should be taught are considered.
Informing patients: The Bolam legacy
Authors: Cave Emma , Milo Caterina
Published: September 2020

In the context of medical advice to patients, the UK decision in Montgomery v. Lanarkshire Health Board rejected the application of Bolam v. Friern Hospital Management Committee. This article argues that the rejection is neither complete nor settled. We explore doctrinal, conceptual and practical limitations of Montgomery to demonstrate the vestiges of Bolam’s relevance to medical advice. Medical advice does not end with disclosure of material risk but incorporates information on prognosis, diagnosis and treatment alternatives. Montgomery does not always apply in these cases, nor outside the medical mainstream or where patients lack capacity to consent. We identify ways in which the extension of patient-centred care in the giving of medical advice can be achieved through incremental development of Montgomery and application of the Bolitho gloss to require that processes conform to Montgomery principles of partnership and autonomy.
Civil courts and COVID-19: Challenges and opportunities in Australia
Authors: McIntyre Joe , Olijnyk Anna , Pender Kieran
Published: September 2020

This article provides an overview of the response of Australian courts to the COVID-19 crisis, and critically examines a number of structures and systemic issues that arise from the shift to the online deliver of justice. It places the current responses in the context of the emerging literature regarding online dispute resolution, and draws upon that literature to consider issues including open justice, symbolism and ‘court architecture’ in the digital space, technological limitations, access to justice and issues of systemic bias. It argues that by examining these issues, the present crisis will help map opportunities for future reform.
Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment
Authors: Di Tizio Federico , Gattazzo Irene , Di Staso Federico , Di Pippo Mariachiara , Guglielmelli Fabio , Scuderi Gianluca
Published: September 2020

Purpose:

To present a modified surgical technique, based on a combination of human amniotic membrane (hAM) patch and autologous Platelet-rich plasma (PRP) in a case of recurrent retinal detachment (RRD) due to a perivascular retinal hole over an area of staphyloma in an eye with pathologic myopia.

Methods:

Presenting the surgical technique with the disposal of surgical video. After performing 23-gauge pars plana vitrectomy (PPV) the hAM patch was inserted under the neuroretina through the perivascular hole and PRP was injected on top to speed up the closure of the hole. To complete the surgical procedure High Viscosity Silicon oil (5000cst) was used as tamponade. The patient was prescribed to maintain a face-down position for the first 3 days after the operation. Follow-up was evaluated through Optical coherence tomography (OCT) scans.

Results:

The 3 days postoperative OCT showed a flat retina with the filling of the myopic staphyloma. The hAM patch was well positioned and the retinal hole could not be identified. At 6 weeks from intervention, the site of the retinal hole at OCT scan was covered by new tissue. Silicone oil was removed 3 months later with no recurrence.

Conclusion:

hAM transplantation is a novel technique in case of retinal detachment recurrences to seal retinal holes over high myopic chorioretinal atrophy. The adjunctive use of PRP and high viscosity silicon oil allows to reducing the standard face-down positioning timing, representing a valid solution for elderly patients who have difficulties maintaining the position for long periods.
Acute syphilitic posterior placoid chorioretinopathy presenting as atypical multiple evanescent white dot syndrome
Authors: Azar Georges , Wolff Benjamin , Azam Stéphane , Mauget-Faÿsse Martine
Published: September 2020

Background:

This paper reports the case of a young man who presented with syphilis masquerading as multiple evanescent white dots syndrome (MEWDS), which turned out to be an acute syphilitic posterior placoid chorioretinopathy (ASPPC) during follow-up.

Case presentation:

A 59-year-old healthy male consulted for a three days’ history of visual impairment in both eyes. On multimodal imaging, he was diagnosed as MEWDS. Fundus fluorescein angiography (FFA) showed early peripheral bilateral granular hyperfluorescence that correlated with the yellow-white dots found on fundus exam. Indocyanine green angiography (ICGA) depicted hypofluorescent dots on late phase. Spectral-domain optical coherence tomography (SD-OCT) revealed numerous inner retinal highly reflective deposits in the outer nuclear layer and disruption of the ellipsoid zone. After initial improvement, he presented again for a sudden visual loss at 3 weeks. FFA, ICGA and SD-OCT demonstrated the same but more numerous and outer lesions suggesting an ASPPC. A full inflammatory work-up revealed highly positive titers of rapid plasma regain (RPR) and fluorescent treponemal antibody absorption (FTA-Abs), suggesting a syphilis infection. The ophthalmological manifestations dramatically improved after the patient was admitted for high-dose intravenous penicillin G 24 million per day for 2 weeks.

Conclusion:

This is the first case that reports an ocular syphilitic infection masquerading as MEWDS at presentation and that turns to be an ASPPC. Syphilis serology should be routinely done in every case of atypical MEWDS especially when unusually presented in a young healthy man, with bilateral involvement and a bad clinical evolution.
ZMAT2 in Humans and Other Primates: A Highly Conserved and Understudied Gene
Authors: Baral Kabita , Rotwein Peter
Published: September 2020

Recent advances in genetics present unique opportunities for enhancing our understanding of human physiology and disease predisposition through detailed analysis of gene structure, expression, and population variation via examination of data in publicly accessible genome and gene expression repositories. Yet, the vast majority of human genes remain understudied. Here, we show the scope of these genomic and genetic resources by evaluating ZMAT2, a member of a 5-gene family that through May 2020 had been the focus of only 4 peer-reviewed scientific publications. Using analysis of information extracted from public databases, we show that human ZMAT2 is a 6-exon gene and find that it exhibits minimal genetic variation in human populations and in disease states, including cancer. We further demonstrate that the gene and its encoded protein are highly conserved among nonhuman primates and define a cohort of ZMAT2 pseudogenes in the marmoset genome. Collectively, our investigations illustrate how complementary use of genomic, gene expression, and population genetic resources can lead to new insights about human and mammalian biology and evolution, and when coupled with data supporting key roles for ZMAT2 in keratinocyte differentiation and pre-RNA splicing argue that this gene is worthy of further study.
Sexting and Substance Use among Women Arrested for Domestic Violence: A Brief Report
Authors: Florimbio Autumn Rae , Brem Meagan J , Grigorian Hannah L , Garner Alisa R , Stuart Gregory L
Published: September 2020

Background:

Advances in technology provide opportunities for communication using electronic mediums. Sexting is one form of electronic communication and includes the sending of explicit sexual content (e.g., photos, text) through electronic mediums. Previous research demonstrated a positive association between sexting and behaviors such as substance use. Moreover, substance use increases the risk for intimate partner violence and is also associated with risky behaviors.

Objectives:

The aim of the present study was to examine the prevalence of sexting in a sample of 84 women mandated to attend batterer intervention programs following arrest for domestic violence. The associations between sexting, substance use, and intimate partner violence were also examined.

Method:

Participants completed self-report questionnaires that assessed sexting, intimate partner violence, and alcohol and drug use symptoms.

Results:

Fifty-four percent of participants reported being asked to send a sext, 35.1% reported sending a sext, and 32.0% reported requesting a sext. Drug use symptoms were positively associated with some forms of sexting and intimate partner violence. There was a significant difference in drug use symptoms, such that women who received a request to send a sext had significantly more symptoms relative to women who had not received a request to send a sext.

Conclusion:

This is the first examination of sexting in a sample of women arrested for domestic violence. Findings indicate an association between drug use symptoms, sexting, and intimate partner violence, warranting continued research in this domain.
Pulmonary Embolism in COVID-19 Treated with VA-ECLS and Catheter tPA
Authors: Akoluk Arda , Mazahir Usman , Douedi Steven , Aziz Adel , Obagi Aref , Kiss Daniel , Flynn Daniel , Costanzo Eric , Simsir Sinan A , Saybolt Matthew D
Published: September 2020

Background:

Novel coronavirus 2019 (COVID-19) has been the focus of the medical world since being declared a pandemic in March 2020. While the pathogenesis and heterogeneity of COVID-19 manifestations is still not fully understood, viral evasion of cellular immune responses and inflammatory dysregulation are believed to play essential roles in disease progression and severity.

Case Presentation:

We present the first case of a patient with COVID-19 with massive pulmonary embolism treated successfully with systemic thrombolysis, VA-ECLS, and bail out catheter directed thrombolysis. He was discharged from the hospital after an eventful hospital course on therapeutic anticoagulation with warfarin.

Conclusions:

We present the first case of a patient with COVID-19 with massive pulmonary embolism (PE) treated successfully with systemic thrombolysis, VA-ECLS and bail out catheter directed thrombolysis. In our experience catheter directed thrombolysis comes with an acceptable bleeding risk despite use of mechanical circulatory support, particularly with meticulous attention to vascular access and dose response monitoring.
Risk factors for leaving employment due to multiple sclerosis and changes in risk over the past decades: Using competing risk survival analysis
Authors: Chen Jing , Taylor Bruce , Blizzard Leigh , Simpson-Yap Steve , Palmer Andrew J , Kirk-Brown Andrea , Van Dijk Pieter , van der Mei Ingrid
Published: September 2020

Background:

No studies have assessed changes in employment survival in multiple sclerosis (MS) populations over recent decades, including the introduction of disease-modifying therapies (DMTs).

Objectives:

To evaluate factors associated with leaving employment due to MS; to assess whether the risk of leaving employment has changed over recent decades in Australia, stratified by MS phenotype.

Methods:

We included 1240 participants who were working before MS diagnosis. Information on employment status, reasons for leaving employment and year of leaving were collected. Data were analysed using competing risk survival analysis.

Results:

Males, progressive MS, lower education level and older age at diagnosis were associated with a higher sub-distribution hazard of leaving employment. Compared to the period before 2010, the sub-distribution hazard during 2010–2016 for relapsing-remitting multiple sclerosis (RRMS) was reduced by 43% (sub-distribution hazard ratio (sHR) 0.67, 95% confidence interval (CI): 0.50 to 0.90), while no significant reduction was seen for primary-progressive multiple sclerosis (PPMS) (sHR 1.25, 95% CI: 0.72 to 2.16) or secondary-progressive multiple sclerosis (SPMS) (sHR 1.37, 95% CI: 0.84 to 2.25).

Conclusion:

Males, people with progressive MS and those of lower education level were at higher risk of leaving employment. The differential changed risk of leaving employment between people with different MS phenotype after 2010 coincides with the increased usage of high-efficacy DMTs for RRMS.
I saw it on YouTube! How online videos shape perceptions of mind, morality, and fears about robots
Authors: Küster Dennis , Swiderska Aleksandra , Gunkel David
Published: September 2020

Robots have the potential to transform our existing categorical distinctions between “property” and “persons.” Previous research has demonstrated that humans naturally anthropomorphize them, and this tendency may be amplified when a robot is subject to abuse. Simultaneously, robots give rise to hopes and fears about the future and our place in it. However, most available evidence on these mechanisms is either anecdotal, or based on a small number of laboratory studies with limited ecological validity. The present work aims to bridge this gap through examining responses of participants ( N = 160) to four popular online videos of a leading robotics company (Boston Dynamics) and one more familiar vacuum cleaning robot (Roomba). Our results suggest that unexpectedly human-like abilities might provide more potent cues to mind perception than appearance, whereas appearance may attract more compassion and protection. Exposure to advanced robots significantly influences attitudes toward future artificial intelligence. We discuss the need for more research examining groundbreaking robotics outside the laboratory.
Large eddy simulation of a double-injection cycle and the impact of the needle motion on the sac-volume flow characteristics of a single-orifice diesel injector
Authors: Chouak Mohamed , Dufresne Louis , Seers Patrice
Published: September 2020

Study of the flow within diesel injector has gained in importance over the years as several authors have reported that the injector flow in the sac volume highly influenced the nozzle-flow characteristics at low lifts. Few studies have, however, characterized the sac volume and its dynamics. Thus, this paper reports on a numerical characterization of the needle displacement effects (static vs dynamic) on the internal flow of a sac-volume, single-hole diesel injector. To this end, a transient double-injection “closing-opening-closing-opening” cycle was simulated with a monophasic incompressible CFD model in combination with a moving mesh strategy to capture axial needle displacement. A large eddy simulation (LES) approach was chosen to gain better insight into the complexity of this unsteady turbulent flow. The emphasis of the paper is on the dynamic effects of needle movement on the sac flow, while static needle LES results are also shown to illustrate differences. The main findings reported herein are that the dynamic model shows a hysteresis effect associated with the needle motion between opening/closing phases. Quantitatively, the transient needle movement caused a difference in mass flow rate between the sac entrance and exit that was found to reach a maximum of [Formula: see text]. The hysteresis effect was found to be more pronounced at low needle lifts; both static and dynamic models seem to have performed similarly at very high needle lifts. Qualitatively, the LES sac-volume flow representations revealed a fuel jet attachment/detachment with needle movement, while static partial-lift simulations always predict an attached fuel jet. Further analysis of sac vortex dynamics revealed a high-energy vortex-structure breakdown just before the nozzle entrance that could help explain the higher turbulence production reported in the literature, both experimentally and numerically, at low needle lifts.
Safety and efficacy of low-dose aspirin in ischemic stroke patients with different G6PD conditions
Authors: Chen Yicong , Li Jianle , Ou Zilin , Zhang Yusheng , Liang Zhijian , Deng Weisheng , Huang Weixian , Wu Zhengdong , Jiang Haihong , Liu Qinghua , Ouyang Fubing , Xing Shihui , Zeng Jinsheng
Published: September 2020

Background and purpose

Aspirin is the first recommended antiplatelet agent to prevention secondary stroke, but its safety and efficacy in stroke patients with glucose-6-phosphate dehydrogenase deficiency remain unclear. We sought to evaluate its safety and efficacy in ischemic stroke patients with and without glucose-6-phosphate dehydrogenase deficiency.

Methods

Patients with ischemic stroke receiving aspirin (100 mg/day) for three months were recruited for a multicenter, prospective, cohort study. Blood glucose-6-phosphate dehydrogenase activity was examined after stroke. Safety outcomes including acute hemolysis, moderate-to-severe bleeding, and death (vascular, all-cause), and efficacy outcome indicated as stroke recurrence were evaluated at three months. Risk factors associated with moderate-to-severe bleeding and all-cause death were determined using multivariate or Cox regression analysis.

Results

Among the included 1121 patients, 81 of 130 glucose-6-phosphate dehydrogenase deficient and 576 of 991 glucose-6-phosphate dehydrogenase normal patients received aspirin for three months. Acute hemolysis was observed in one of the glucose-6-phosphate dehydrogenase deficient and in none of the glucose-6-phosphate dehydrogenase normal patients ( p = 0.876). The rates of moderate-to-severe bleeding were 2.5% and 0.3% ( p = 0.045), and the percentages of all-cause death were 6.2% and 1.4% ( p = 0.008) in the glucose-6-phosphate dehydrogenase deficient and glucose-6-phosphate dehydrogenase normal patients. Stroke recurrence rate was similar in the two groups (2.5% vs. 1.7%; p = 0.608). Glucose-6-phosphate dehydrogenase deficiency was significantly associated with increased risk of moderate-to-severe bleeding (adjust p = 0.048) and all-cause death during aspirin use (adjust p = 0.008).

Conclusions

Long-term low-dose aspirin therapy might relate to worse safety outcomes in patients with glucose-6-phosphate dehydrogenase deficiency and large clinical trials are needed to further confirm these findings.
Autophagy plays a protective role during Pseudomonas aeruginosa-induced apoptosis via ROS–MAPK pathway
Authors: Han Lu , Ma Qinmei , Yu Jialin , Gong Zhaoqian , Ma Chenjie , Xu Yanan , Deng Guangcun , Wu Xiaoling
Published: September 2020

Pseudomonas aeruginosa infection can induce alveolar macrophage apoptosis and autophagy, which play a vital role in eliminating pathogens. These two processes are usually not independent. Recently, autophagy has been found to interact with apoptosis during pathogen infections. Nevertheless, the role of autophagy in P. aeruginosa-infected cell apoptosis is unclear. In this study, we explored the impact of P. aeruginosa infection on autophagy and apoptosis in RAW264.7 cells. The autophagy activator rapamycin was used to stimulate autophagy and explore the role of autophagy on apoptosis in P. aeruginosa-infected RAW264.7 cells. The results indicated that P. aeruginosa infection induced autophagy and apoptosis in RAW264.7 cells, and that rapamycin could suppress P. aeruginosa-induced apoptosis by regulating the expression of apoptosis-related proteins. In addition, rapamycin scavenged the cellular reactive oxygen species (ROS) and diminished p-JNK, p-ERK1/2 and p-p38 expression of MAPK pathways in RAW264.7 cells infected with P. aeruginosa. In conclusion, the promotion of autophagy decreased P. aeruginosa-induced ROS accumulation and further attenuated the apoptosis of RAW264.7 cells through MAPK pathway. These results provide novel insights into host–pathogen interactions and highlight a potential role of autophagy in eliminating P. aeruginosa.
Capturing the costs of acute hand and wrist injuries: Lessons learnt from a prospective longitudinal burden of injury study
Authors: Robinson Luke Steven , Brown Ted , O’Brien Lisa
Published: September 2020

Introduction

Given the high incidence of hand and wrist injuries, they are exceptionally costly to the economy. This prospective, longitudinal study aimed to establish methods for capturing the burden of acute hand and wrist injury from an individual and societal perspective.

Methods

A prospective longitudinal design with baseline measures of injury type and severity, and repeated measures of disability, cost, and activity limitations and participation restrictions at six weeks, three months, and six months was selected. Participants were recruited from two large urban Australian public health care services. We sought to establish methods for capturing the burden of acute hand and wrist injury from an individual and societal perspective and compare survey completion by the method of administration.

Results

A total of 206 patients consented to participate in this study, representing 54% of those invited to participate. The survey completion rates were 18% at six weeks, 2.4% at twelve weeks, and 0.004% at six months following injury. From the limited data collected at six weeks, it was noted that nearly half of the patients reported a decrease in usual financial income, 14% reported absenteeism, and 62% reported presenteeism. Participants who elected to have data collected via phone call had the highest survey completion rate ( n = 6/10; 30%) at six-week’s follow-up.

Discussion

The study findings highlight the difficulties of completing longitudinal survey research investigating individual and societal burden with this population. Future research should be carefully designed to encourage participation and retention by considering patient and public involvement in study design, the time burden placed on the participants within and across selected survey time points, providing participants with incentives to participate, and highlighting the relevance and real-world applications of the findings.
An Analysis of 2019 FDA Adverse Events for Two Insulin Pumps and Two Continuous Glucose Monitors
Authors: Krouwer Jan S.
Published: September 2020

US Food and Drug Administration adverse event data for 2019 were analyzed for two insulin pumps and two continuous glucose monitors (CGMs). The analyses were selective—they were guided by the text described in the adverse events. They included (1) percent using auto mode for the Medtronic 670G pump, (2) distributions of hyper and hypo glucose values for Medtronic and Tandem pumps, (3) a Parkes error grid for Dexcom CGM vs glucose meter when the complaint was inaccuracy, and (4) the most frequent events for Abbott Freestyle. We found that for the 670G pump, there were more hypo events when auto mode was on than when auto mode was off. With Dexcom CGMs, users complained about inaccurate result when most results were in the B zone. With the Abbott Freestyle, the most frequent adverse event was an allergic skin reaction.
Does Functional Bracing of the Unstable Shoulder Improve Return to Play in Scholastic Athletes? Returning the Unstable Shoulder to Play
Authors: Kwapisz Adam , Shanley Ellen , Momaya Amit M. , Young Chris , Kissenberth Michael J. , Tolan Stefan J. , Lonergan Keith T. , Wyland Douglas J. , Hawkins Richard J. , Pill Stephan G. , Tokish John M.
Published: September 2020

Background:

Functional bracing is often used as an adjunct to nonoperative treatment of anterior shoulder instability, but no study has evaluated the effectiveness of in-season bracing. The purpose of this study was to examine successful return to play in a nonoperative cohort of adolescent athletes with in-season shoulder instability and compare those athletes treated with bracing to those who were not.

Hypothesis:

The use of functional bracing will improve success rates in a cohort of athletes treated nonoperatively for in-season shoulder instability.

Study Design:

Cohort study.

Level of Evidence:

Level 3.

Methods:

A total of 97 athletes with anterior shoulder instability were followed for a minimum of 1 year. The mean age was 15.8 ± 1.4 years (range, 12.0-18.0 years). All athletes were treated with initial nonoperative management. Twenty athletes (21%) were also treated with bracing while 77 (79%) were not. The athlete completing the current season and 1 subsequent season without surgery or time lost from shoulder injury was defined as a successful outcome.

Results:

There was no statistical difference in nonoperative success rates between the braced and nonbraced athletes ( P = 0.33). Braced athletes (n = 20) returned to play 80% of the time, while nonbraced athletes (n = 77) returned at a rate of 88%. Of the braced athletes, 85% were football players (n = 17). A football-only comparison demonstrated no difference between braced failures (26%) and nonbraced failures (16%) ( P = 0.47).

Conclusion:

This is the first study to evaluate the utility of functional bracing in returning an athlete to sport and completing a full subsequent season without surgery or time loss due to injury of the shoulder. In adolescent athletes with shoulder instability treated nonoperatively, functional bracing did not result in increased success rates when compared with no bracing.

Clinical Relevance:

The data from this study indicate that functional bracing may not improve success rates for athletes with shoulder instability.
A single-centre observational study comparing the impact of different cytomegalovirus prophylaxis strategies on cytomegalovirus infections in kidney transplant recipients
Authors: Tan Mabel Si Hua , Chung Shimin Jasmine , Ho Quan Yao , Thangaraju Sobhana , Kee Terence Yi Shern
Published: September 2020

Background/objective:

Prevention of cytomegalovirus (CMV) infection is an important component of post kidney transplant care. We aimed to evaluate the impact of two different CMV prophylaxis protocols on the epidemiology and outcomes of CMV infections at our centre.

Methods:

This is a single-centre retrospective before/after observational study. Kidney transplant recipients who received Protocol 1, a valacyclovir- or valganciclovir-based regimen prescribed for one to three months based on the CMV risk status between 2004 and 2008, were compared to those who received Protocol 2, a valganciclovir-based regimen prescribed for three months and six months for those at moderate and high risk, respectively, between 2010 and 2014. The impact of different prophylaxis regimens on the incidence of CMV infections, disease, recurrent infections and onset of CMV infection at 24 months were reviewed.

Results:

There were 192 patients included; 106 patients received Protocol 1, 86 received Protocol 2. At 24 months, the incidence of CMV infection was 53.8% and 55.8% in Protocols 1 and 2, respectively ( p=0.884). The incidence rates of CMV disease and recurrent CMV infections were higher in Protocol 1, but this was not statistically significant. The median time to first CMV infection was significantly shorter in patients who received Protocol 1: 132 days (interquartile range (IQR) 125–139 days) versus 185 days (IQR 178–192 days), p=0.001. Both prophylaxis protocols were well tolerated.

Conclusion:

The incidence of CMV infection was similar in both protocols. Where valganciclovir is not available, valacyclovir may be considered over no prophylaxis. Post-prophylaxis CMV infections are not uncommon, and vigilance for it should be advocated.
Networked Remembrance in the Time of Insta-Memories
Authors: Serafinelli Elisa
Published: September 2020

Since its invention, photography has always maintained a close relationship with the concept of preserving memory of the past and stopping the passage of time. In the digital age, this function is influenced by the arrival of the internet, social media platforms, and smart phones. Considering recent technological developments, this article explores the practice of photosharing on Instagram and how this popular platform is changing the way people think about and practice visual remembering. To do so, this article explores these issues qualitatively, using netnography, computer-mediated interviews, online participant observation, and visual content analysis. Findings show that digital photography does not walk away from its traditional function of maintaining memories of the past—instead new and creative practices have developed. In allowing users to share visual narratives, Instagram has led to the creation of “networked archives” of both personal and collective memories.
Interdisciplinary Surgical Management of Simultaneous Bone Metastases in Uterine Cervix Carcinoma: Total Replacement of Temporomandibular Joint and Stabilization of the Cervical Spine
Authors: Eckardt André M. , Reichstein Klaus , Heine M.
Published: September 2020

Metastasis to the mandibular condyle and cervical spine in oncologic patients is rare, and clinicians should therefore be alert if patients present with such suspicious lesions for further clinical and pathological examinations.  A 58-year old female patient with uterine cervical cancer initially presented with mild left condylar dysfunction. CT-imaging revealed a progressive osteolytic lesion of the left condyle and at the same time CT-scans revealed an osteolytic lesion of the cervical spine. Further metastatic bone lesions were ruled out. An incisional biopsy of the left condyle revealed metachronous metastasis from the uterine cervical carcinoma. Based on clinical and radiological examinations the patient underwent surgery with total alloplastic replacement of the temporomandibular joint (TMJ) and in a second surgical approach stabilization of the cervical spine. Suspicious symptoms with TMJ dysfunction in conjunction with osteolytic lesions of the maxillofacial skeleton in oncologic patients should be addressed quickly to prevent further diagnostic delay. Surgical resection of metastatic lesions should be considered as a palliative treatment option in selected patients.
A Simple Method for Percutaneous Reduction of Isolated Zygomatic Arch Fractures With a Dental Elevator: A Technical Note
Authors: Sorghabi Wais , Kleinbergen Jurrijn , Bos Ruud , Van Minnen Baucke
Published: September 2020

Isolated zygomatic arch fractures are common fractures of the facial skeleton. Dislocation may result in facial disharmony and/or restricted mouth opening if not treated properly. Different methods of minimally invasive treatment of depressed fractures of the zygomatic arch have been described. Most of them are based on either a direct percutaneous approach with a malar hook, a temporal approach according to Gillies, or transorally according to Keen. For these methods, general anesthesia is often preferred. In this technical note, an alternative method of a percutaneous approach for reduction of a zygomatic arch fracture under local anesthesia is presented.
Beyond Entanglement: (Socio-) Materiality and Organization Studies
Authors: Cooren François
Published: September 2020

Although we have to welcome the renewed interest in socio-materiality in organization studies, I claim that we are yet to understand what taking matter seriously really means. The mistake we especially need to stop making consists of automatically associating matter to something that can be touched or seen, that is, something tangible or visible, an association that irremediably leads us to recreate a dissociation between the world of human affairs and the so-called material world. To address this issue, I mobilize a communication-centered perspective to elaborate that (1) materiality is a property of all (organizational) phenomena and that (2) studying these phenomena implies a focus on processes of materialization, that is, ways by which various beings come to appear and make themselves present throughout space and time. In the paper I conceptualize the contours of these materialization processes and discuss the implications of this perspective on materiality for organizational theory and research.