bluuebunny/crossref_metadata_2025 huggingface dataset:
Divine Temporality and Providential Bodgery
Authors: Mullins Ryan T.
Published: November 2020

In contemporary debates, one is presented with temporal and timeless conceptions of divine eternality. Each conception is said to have various consequences for understanding divine perfection and providence. In this paper, I shall consider a pair of arguments against divine temporality that suggest that a temporal God could potentially make mistakes, thus making the temporal God less than perfect. I shall develop these objections, and discuss various ways for the temporalist to reply.
Immersive telepresence in theatre: performing arts education in digital spaces
Authors: Gorman Tom , Kanninen Mikko , Syrjä Tiina
Published: November 2020

This case study examines a joint project in performer training and rehearsal conducted between Coventry University (UK) and Tampere University (Finland) using a variety of telepresence and app-based technologies. In this project, two identical spaces, equipped with rear projection screens and linked by videoconferencing technology, were created in both institutions. This study reports on the adaptation of the pedagogical practices to a digital setting.
Recognising participation in virtual exchange: open badges and the CLAVIER contribution
Authors: MacKinnon Teresa , Ensor Simon , Kleban Marcin , Trégoat Claude
Published: November 2020

The CLAVIER (Connected Learning And Virtual Intercultural Exchange Research) network grew rhizomatically as a result of open practice (Blyth, 2019), which is central to the CLAVIER approach. Informed by the field of Computer-Mediated Communication (CMC), the network has provided a safe space to experiment with the development and implementation of open badges to support sustained participation in Virtual Exchanges (VEs). This case study describes the rationale for CLAVIER’s open badge framework and its links with the Erasmus+ VE (E+VE) badges.
Virtual exchange strengthens international youth work
Authors: Van de Kraak Sandra , Lai Jan
Published: November 2020

Pathways to Youth Leadership was an Erasmus+: Youth in Action long term training involving 24 youngsters from 12 countries. Grant cuts required squeezing the residential programme, originally planned to last three weeks, into two. That is why, after taking part in the Erasmus+ Virtual Exchange (E+VE) training, we successfully added five VE sessions to the project. Youth work relies on personal interaction, experiential learning, and non-formal education. Transferring that into online interaction has been our greatest innovation and challenge. In our field, there is resistance to online activities, but the Covid-19 pandemic is changing this. We need to practise online facilitation, develop the required skills, and define the role E+VE can play in youth work.
Women in Engeenering – Dynamics of Access to Studies and Professional Career
Authors: Szymczak Emilia
Published: November 2020

This article describes the history of women in the engineering world, the changing social and economic conditions and women’s rising educational aspirations (it appears that they are interested in the traditional scientific disciplines but they also increasingly with to try typically male – form the point of view of traditional socialization – educational and then professional careers). The article presents the dynamics of the access of women to higher education through the years, including especially scientific and technical fields of study. It also presents the statistical data about the participation of women in the stereotypically male areas of education. This article provides historical examples of women, famousbecause of their spectacular scientific achievements.
Interrelationships between Cellular Density, Mosaic Patterning, and Dendritic Coverage of VGluT3 Amacrine Cells
Authors: Keeley Patrick W. , Lebo Mikayla C. , Vieler Jordan D. , Kim Jason J. , St. John Ace J. , Reese Benjamin E.
Published: November 2020

Amacrine cells of the retina are conspicuously variable in their morphologies, their population demographics, and their ensuing functions. Vesicular glutamate transporter 3 (VGluT3) amacrine cells are a recently characterized type of amacrine cell exhibiting local dendritic autonomy. The present analysis has examined three features of this VGluT3 population, including their density, local distribution, and dendritic spread, to discern the extent to which these are interrelated, using male and female mice. We first demonstrate thatBax-mediated cell death transforms the mosaic of VGluT3 cells from a random distribution into a regular mosaic. We subsequently examine the relationship between cell density and mosaic regularity across recombinant inbred strains of mice, finding that, although both traits vary across the strains, they exhibit minimal covariation. Other genetic determinants must therefore contribute independently to final cell number and to mosaic order. Using a conditional KO approach, we further demonstrate thatBaxacts via the bipolar cell population, rather than cell-intrinsically, to control VGluT3 cell number. Finally, we consider the relationship between the dendritic arbors of single VGluT3 cells and the distribution of their homotypic neighbors. Dendritic field area was found to be independent of Voronoi domain area, while dendritic coverage of single cells was not conserved, simply increasing with the size of the dendritic field.Bax-KO retinas exhibited a threefold increase in dendritic coverage. Each cell, however, contributed less dendrites at each depth within the plexus, intermingling their processes with those of neighboring cells to approximate a constant volumetric density, yielding a uniformity in process coverage across the population.

SIGNIFICANCE STATEMENTDifferent types of retinal neuron spread their processes across the surface of the retina to achieve a degree of dendritic coverage that is characteristic of each type. Many of these types achieve a constant coverage by varying their dendritic field area inversely with the local density of like-type neighbors. Here we report a population of retinal amacrine cells that do not develop dendritic arbors in relation to the spatial positioning of such homotypic neighbors; rather, this cell type modulates the extent of its dendritic branching when faced with a variable number of overlapping dendritic fields to approximate a uniformity in dendritic density across the retina.
Organizational Forms and Methods of Overcoming Pedagogical Risks in the Management of Innovative Educational Platform
Authors:   Moscow socio-economic institute, Кiseleva Olga Olegovna
Published: November 2020

The article actualizes the problem of planning ways to overcome pedagogical risks. The purpose of the article is to identify methods of overcoming the pedagogical risks of managing innovative platforms in education, to substantiate the classification of such methods. Research methodology and methods. The methodological basis of the study is a systematic approach, which made it possible to consider the interrelationships of the management elements of the innovation platform. To achieve the goal of the study, methods of analysis of the fundamental ideas of pedagogical science and the theory of risk management, modeling of content analysis of projects of existing federal innovation platforms, ranking of methods for minimizing pedagogical risks in the management of an innovative educational platform were used. Research results. As a result of the study, a structural model of forms and methods of overcoming the pedagogical risks of managing an innovative educational platform was created, the prevailing forms and methods of overcoming the pedagogical risks of managing an innovative educational platform were identified.In conclusion, it is concluded that the methods of overcoming pedagogical risks are adequate to the management require the use of mainly pedagogical forms and methods of minimizing such risks, and the phenomena of the organization of activities determine the priority of management methods to neutralize risks. the teaching staff of the innovation platform.
Research of the Attitude of Students of Pedagogical Profiles for Future Professional Activity
Authors:   Novokuznetsk Institute (branch) of the Kemerovo State University, Elkina Olga Yurievna , Lozovan Lyubov Yaroslavovna ,   Novokuznetsk Institute (branch) of the Kemerovo State University, Martynova Alla Vasilievna ,   Novokuznetsk Institute (branch) of the Kemerovo State University
Published: November 2020

The article presents the results of studying the relationship of students to future professional activities, describes the dynamics of changes in their relationship to pedagogical activity in the process of studying of pedagogical disciplines, examines the causes affecting the formation of positive attitude of students to this professional activity. The purpose of the article is a quantitative and qualitative analysis of the results of a diagnostic study among 1st – 5th year students enrolled in pedagogical profiles of full – time bachelor’s degree programs of the Novokuznetsk Institute (branch) Kemerovo state University, aimed at identifying their attitude to future teaching activities. Methodology. To achieve this goal, a set of complementary methods was used: conceptual analysis of psychological and pedagogical literature to identify the initial research positions; generalization of scientific information obtained during the research; diagnostic methods (pedagogical observation, conversation, study of products, questionnaires, testing, etc.); methods of mathematical processing of primary data (statistical processing of experimental results and their analysis, graphical interpretation of research results, etc.). Results. It is proved that the formation of a positive attitude of students of pedagogical profiles of preparation for future teaching activities is influenced by their difficulties and disturbing expectations.
An Empirical Study of the Use of Mirror Repetition Technology as a Means of Phonetic Re-Printing (On the Example of Students With Visual Impairment)
Authors:   Novosibirsk State Pedagogical University, Zaitceva Mariya Vladimirivna , Voloshina Tatyana Victorovna ,   Novosibirsk State Pedagogical University
Published: November 2020

The article speculates upon the problem of phonetic re-imprint forming through the acoustic mirroring technology application. The aim is to represent and analyse the results of the empirical study held as part of our scientific research and to consider the effectiveness of the acoustic mirroring technology application. Methodology. The study was carried out on the basis of theoretical and practical analysis within the framework of activity and system approaches. Results. The authors highlight the effectiveness of imitation and mirroring mechanisms. Theoretical basis of re-imprint pattern forming mechanism as well as the empirical study results are given in the research paper. Student t-criterion for linked samples was applied to calculate the acoustic mirroring technology effectiveness. Taking into account the research data we can say that the acoustic mirroring technology is more effective for post-sensitive period phonetics mastering compared with standard methods. Conclusion. The acoustic mirroring technology application effectiveness for re-imprint forming is proved and fortified through the empirical research and analysis. We do not deny the importance of standard phonetics mastering methods but we consider it to be less effective for the phonetic re-imprint forming then the acoustic mirroring technology.
Functional Development of Children 6–7 years old with Different Levels of Informatization of Living Conditions
Authors:   Institute of the Russian Academy of Education Institute for Developmental Physiology, Krivolapchuk Igor Allerovich , Gerasimova Anstasia Allerovna ,   Institute of the Russian Academy of Education Institute for Developmental Physiology, Chernova Maria Borisovna ,   Institute of the Russian Academy of Education Institute for Developmental Physiology
Published: November 2020

Currently, world science is actively conducting research aimed at analyzing the influence of the modern digital environment on motor fitness, physical development and functional capabilities of preschoolers. Despite the available data, the problem under consideration remains poorly understood, especially in relation to preschool children. The aim of the study is to identify the features of the functional development of children 6–7 years old, taking into account the level of informatization of living conditions. Research methodology. The study involved practically healthy children 6–7 years old. To assess the information load of children when using digital technologies, a modified index of informatization of living conditions was used. The set of physical fitness tests included control exercises to assess speed, speed-strength, coordination motor abilities, flexibility, general and strength endurance. According to the well-known formulas, a double product, Kerdo’s vegetative index, Myznikov’s index, an indicator of the body’s adaptive potential and body mass index were determined. Results. The data obtained indicate that boys, on average, are characterized by a higher indicator of informatization of living conditions in comparison with girls. The differences were revealed, determined by the degree of informatization of living conditions, in terms of general and strength endurance, speed, speed-strength and coordination abilities, physical development, as well as the functional capabilities of the organism. The results of the study give grounds to believe that an adequate mode of physical education, ensuring the satisfaction of the biological needs of children for physical activity, may be the most important factor in increasing their motor fitness, preventing adverse changes in functional development with the active use of digital technologies in everyday life. Conclusions. Analysis of the influence of digital technologies on the functional development of children aged 6–7 years has shown that the features of motor fitness, functional capabilities of the body and physical development of boys and girls aged 6-7 years depend on the level of informatization of living conditions. It turned out that with an increase in the time of using digital technologies in the daily routine, there is a decrease in the considered indicators of the morphological and functional development of children.
Modern Scientific Understanding of the Concept «Spiritual and Moral Education»: Theoretical Aspect
Authors:   Voronezh state pedagogical University, Veretennikova Svetana Viktorovna
Published: November 2020

Problem and goal. “Spiritual and moral education” is a key category of a number of Federal regulations that have come into force over the past decade. However, this category is not always interpreted unambiguously by the scientific and pedagogical community. The purpose of the article: to consider how “spiritual and moral education” is understood in the modern scientific and pedagogical discourse. Research base and literature. The article provides a review of scientific works published in 2019 on the pedagogical category “spiritual and moral education”, which is a key one in the leading legal acts. The review was based on publications published on the neb portal eLIBRARY.RU. in the public domain, in which the category under study is included in the title of the work, annotation, and / or keywords. Statistics are provided that reflect the geography of the publications under consideration, the value bases of spiritual and moral education, and groups of authors. Research base and literature. This review focuses on publications of a theoretical nature, which made up ⅓ of all the considered works. All publications of a theoretical nature are conditionally divided into works of “spiritual” (meaning-seeking) and” moral» (behavioral) orientation; their distinctive features and value bases are considered. The article analyzes publications that present a retrospective analysis of spiritual and moral education. Conclusion. The essential characteristics of spiritual and moral education are revealed. The analysis showed that they are updated in only one-third of the reviewed publications; the remaining two-thirds are devoted to the external side of its organization. Although most authors assign a strategic role to spiritual and moral education not only in solving educational problems, but also in stabilizing society, this category is considered in isolation from the experience of the past and without a proper understanding of the role of the teacher.
Entrenamiento de la pliometría y propiocepción en discapacidad cognitiva, síndrome de Down y autism
Authors: Aguilar Mejía Cesar Alonso , Rodríguez Cepeda Ricardo
Published: November 2020

El propósito de esta investigación fue contribuir en la mejora de la estabilidad postural estática unipodal (epeu) y la capacidad de salto vertical (csv) por medio del entrenamiento de la pliometría y propiocepción en sujetos con síndrome de Down (sd), autismo (a) y discapacidad cognitiva (dc) de la ciudad de Bogotá, Colombia, en el 2019. Como método se utilizó la valoración de la epeu, que se ejecutó bajo el protocolo de Iowa Brace (ib), y la csv, bajo el protocolo de Abalakov (abk). Se realizó un entrenamiento de propiocepción y pliometría de dos meses y tres semanas (once semanas) con una frecuencia de dos sesiones semanales y una duración por sesión de dos horas. Se obtuvo como resultados una mejora significativa en la csv (r = 0.95, et (Error típico) 2.81, p < 0.000) y en la epeu (r = 0.57, et = 0.60, p < 0.005). Hubo un cambio entre el pre y postest de un 23.7 % a favor del protocolo de abk, y un 48.4 % favorable con el protocolo ib. Se concluyó que ambos tipos de entrenamiento (pliométrico y propioceptivo) mejoran significativamente la epeu y la csv en sujetos con sd, a y dc, contribuyendo a la coordinación y estabilidad de gestos mecánicos cotidianos y disminución de la pérdida del equilibrio. Se recomiendan entrenamientos de fortalecimiento (en glúteos y core) y de corrección postural.
COVID 19 frente a los avances de la ciencia
Authors: Olga Lucia Ostos Ortiz
Published: November 2020

Curso para padres de Familia USTA – “ROCCA SECCA” - Módulo de herramientas para la investigación y la innovación: Descubrimientos de la ciencia, COVID 19, qué enfrentamos perspectiva y prospectiva desarrollada por la Dirección de Investigación e Innovación.
Cyclic loading test of a bamboo-steel hybrid frame with novel energy-dissipation connections
Authors: Wang Yanhua , Feng Yan , Huang Zirui , Chen Zhongfan
Published: November 2020

Pseudo-static tests of a novel energy-dissipation connection, comprised of a hinge and two steel brackets, have proven their reliability and superior energy-dissipation capability. To verify the effectiveness of the connection further, a full-scale one-story one-bay engineered bamboo-steel hybrid frame jointed with the novel energy-dissipation connections was investigated through experimental test and finite element analysis (FEA) in this paper. The experimental results showed that the failure mode of the frame was restricted in the local buckling of the energy-dissipation panels (EDPs) in the innovative connections, whereas no obvious damage was observed in the other components of the frame. The hysteresis loops of the frame with energy dissipation connections revealed less pinching. Thus, the ductility and damping ratio of the engineered bamboo-steel frame can reach 1.46 and 14.1%, respectively. Based on the analysis of effectual simulation models in ABAQUS software, the relationship between the initial stiffness, the peak load, the ductility ratio of the hybrid frame and the size of EDP was studied. Recommendations are made for the design of the EDPs.
Beta Decay Studies of Nuclides in the Heavy Region
Authors: M.K. Preethi Rajan  , R.K. Biju R.K. Biju , K.P. Santhosh K.P. Santhosh
Published: November 2020

In the present work we studied the β-decay of various isotopes in the heavy region using the empirical formula of Fiset and Nix. It is found from the half-life that as the neutron number increases the possibility of β-decay increases. From the dependence of beta decay half-life on neutron number of parent and Q-value, we modified empirical formula of Fiset and Nix for beta decay half-life. We also developed an empirical formula for the Z-value of most stable isobar against β-decay. From the study of mass parabola for different isobars with mass number ranging from 200-223 it was found that the lowest point in the parabola, which is the Z-value of most stable isobar against β-decay, matches well with our formula predictions.
ASSESSMENT OF THE ECOLOGICAL CONDITIONS OFFERED BY DECIDOUS STANDS FROM THE NORTHERN ROMANIA FOR THE AVIAN POPULATIONS
Authors: Măciucă Anca , Dănilă Alin
Published: November 2020

Bird populations are fundamental elements of forest biodiversity and play a very important role in maintaining the ecological balance and normal functions of forest ecosystems, so that they are an indicator of sustainable management taken into account at European level. Consequently, the existence or setting up by management measures of the most favourable conditions for diverse assemblages of birds is one of the objectives of sustainable forest management. For this purpose the paper aims to assess the ecological conditions offered by broadleaved stands from the northern Romania for the avian populations. The parameters considered were the stands layers, the composition and spatial distribution of forest shrubs, the stand density, the biological potential of forest species, stand age and stand ecological dynamic, landscape parameters. Using these parameters as partial favourability indices, a simple method for assessing the ecological conditions offered to bird populations based on a Total Favourability Index (TFI) is proposed for practical forest management purposes. According to this index, in the case study of the northern broadleaved managed stands, the ecological favourability for birds is medium.
PRIORITIZING THE POTENTIAL OF NON-WOOD FOREST PRODUCTS FROM ARAD COUNTY BY USING THE ANALYTICAL HIERARCHY PROCESS
Authors: Pleșca Ioana Maria , Blaga Tatiana , Dincă Lucian , Breabăn Iuliana Gabriela
Published: November 2020

Romanian forest management plans and policies, traditionally focused on timber production, need to reconsider the NWFPs (non-wood forest products) importance in the development of the socio-economic sector. Within the country’s forestry economy, the nature, quantity and weight of NWFPs are variable factors from one county to another, influenced to a large extent by the area covered by forests. The aim of this study is to unravel the most important NWFPs available in Arad County. In order to analyze the potential of NWFPs, data from the forest management plans of the ten subunits within the structure of the Arad Forest Directorate and statistical data from various institutions were used. In accordance with the purpose of the study, NWFPs were clustered into four categories as designed in the European project COST FP1203 European Non-Wood Forest Products (NWFPS) Network: mushrooms, tree products, understory plants and animal origin products. Eight different types of NWFPs were identified and analyzed using the analytic hierarchy process. Potential NWFPs were prioritized in accordance with the 19 criteria selected, and thus the most promising NWFPs were determined. Subsequently, AHP results were implemented in the Choice Expert Desktop software package. The results of the study indicate that Coturnix coturnix and Vulpes vulpes are in the top of the most promising NWFPs. More importantly, the obtained results can help to better address the management of NWFPs from Arad County.
Számít-e a gyógyszer dózisa a túlérzékenységi reakciókban?
Authors: Jenei Kluch Lenke , Erdei Irén , Remenyik Éva , Surányi Éva , Bodnár Ferenc , Emri Gabriella , Szegedi Andrea
Published: November 2020

Összefoglaló. Két fiatal nőbetegnél a valproátról lamotriginre
történő gyógyszerátállítás során a 3–4. héten influenzaszerű prodromalis
tüneteket követően toxikus epidermalis necrolysis (TEN), más néven
Lyell-szindróma alakult ki. Mindkét beteg 5 napja kezdődött bőr- és
nyálkahártyatünetekkel, kiterjedt hámleválást okozó hámnekrózissal került
felvételre a Debreceni Egyetem Bőrgyógyászati Klinikájának Égési Intenzív
Osztályára. Multidiszciplináris szupportív terápia mellett nagy dózisú szteroid-
és immunglobulin-terápiát alkalmaztunk. A 37 éves nőbetegnél 3 hét után a kórkép
fatális kimenetellel végződött. A 19 éves nőbeteg tünetei 4 hét intenzív terápia
után szövődményekkel gyógyultak. A TEN ritka, gyógyszer által okozott, életet
veszélyeztető, késői hiperszenzitivitási reakció. Patogenezisében a
gyógyszermolekula, a humán leukocytaantigén (HLA) I. osztályú molekula és a
T-sejt-receptor kóros interakciója szerepel. Kezelésében a legfontosabb a
kiváltó gyógyszer elhagyása, valamint az azonnal kezdett komplett szupportív
terápia alkalmazása. A specifikus kezelést illetően nincsenek egységes szakmai
irányelvek. A veszélyes gyógyszerek titrált bevezetése csökkentheti a kialakuló
hiperszenzitivitás súlyosságát, ezenfelül a beteg szoros követése és az adverz
tünetek korai felismerése javíthatja a TEN kimenetelét. Orv Hetil. 2020;
161(46): 1959–1965.

Summary. After switching from valproate to lamotrigine, on the
3rd–4th weeks, two young female patients developed flu-like prodromal symptoms,
followed by the development of toxic epidermal necrolysis (TEN), also known as
Lyell syndrome. Both patients were admitted to the Burn Intensive Care Unit of
the Department of Dermatology, University of Debrecen with skin and mucosa
symptoms; extensive epithelial death and detachment started 5 days earlier. In
addition to multidisciplinary supportive treatment, high-dose corticosteroid and
immunoglobulin therapy were administered. In the case of the 37-year-old female
patient, the disease resulted in a fatal outcome. The 19-year-old patient healed
with some sequelae. TEN is a rare, life-threatening delayed-type
hypersensitivity reaction caused by drugs. Its pathogenesis involves an
interaction between small-molecule drug, human leukocyte antigen class I
molecule and T-cell receptor. The most important treatment is immediate
withdrawal of potentially causative drugs and prompt application of supportive
therapy. There is no standard guidance on specific treatment. Slow dose
escalation of dangerous drugs can be beneficial in avoiding severe reactions,
furthermore, close patient follow-up and early detection of the possible adverse
reactions contribute to a more favourable outcome of TEN. Orv Hetil. 2020;
161(46): 1959–1965.
The management of gynecological patients with varicose veins disease
Authors:   Kharkiv Medical Academy of Postgraduate Education, Ukraine, Lakhno I.V.
Published: November 2020

The review of existing concepts of the pathogenesis, clinical manifestations, diagnosis and treatment of varicose veins of the lower limbs and pelvic organs in women was performed. A significant negative impact of hormone-induced phlebopathy and chronic pelvic pain syndrome of circulatory genesis on the quality of life of gynecological patients was shown. The conclusion about the expediency of usage taking into account the possible benefits of the drug Venovital to treat women with varicose veins disease was done. Key words: varicose veins disease, treatment, Venovital.
Forecasting of unsuccessful attempts of auxiliary genesial technologies
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Paluga I.E.
Published: November 2020

The objective: development of algorithm of forecasting of unsuccessful attempts of auxiliary genesial technologies on the basis of the mathematical analysis of the main reasons and risk factors. Patients and methods. 97 married couples which passed sterility treatment on the basis of clinic of auxiliary genesial technologies were surveyed. The complex of the conducted researches included clinical, endocrinologic, immunohistochemical, ehografical and statistical methods. Results. For forecasting of unsuccessful attempts of auxiliary genesial technologies it is necessary to use the constructed mathematical model which includes 4 most significant changes (as significance value depression): optical density of an expression of LIF in superficial and glandular epithelium the endometrium, received in the period of assumed «implantation windows» in cycle before carrying out an extracorporal fertilization, the maintenance of VEGF in cervical slime in day of transvaginal puncture, S/D and IR of spiral arteries in day of introduction of triger of an ovulation. Conclusion. Use of offered algorithm allows to increase forecasting effectiveness of unsuccessful attempts of auxiliary genesial technologies. Key words: auxiliary genesial technologies, unsuccessful attempts, forecasting.
Decompensation placental dysfunction: diagnostics and delivery tactics
Authors:   Medical Institute of Sumy State University, Ukraine, Boyko V.I. , Tkachenko S.A. ,   Medical Institute of Sumy State University, Ukraine
Published: November 2020

The objective: depression of frequency of perinatal pathology at women with decompensation form of placental dysfunction by improvement of the main diagnostic and treatment-and-prophylactic actions. Patients and methods. 154 pregnant women in gestation term from 22 to 40 weeks were surveyed. Depending on features of course of pregnancy and families of all surveyed it was divided into 4 groups. The group of the retrospective analysis was made by 45 pregnant women with decompensation placental dysfuction, the group of prospective research included 109 pregnant women of whom the main group was made by 38 women with decompensation form of placental dysfunction, the group of comparison included 47 pregnant women with the compensated form of placental dysfunction. The control group was made by 24 pregnant women with the uncomplicated course of pregnancy and labors. The complex of the conducted researches included clinical, ehografical, dopplerometrical, laboratory, morphological and statistical methods. Results. Use of advanced algorithm of diagnostic and treatment-and-prophylactic actions allows to increase efficiency of diagnostics of decompensation form of placental dysfunction for 33.3%, and rational tactics of a delivery leads to depression of perinatal pathology for 22.7%. Conclusion. Decompensation placental dysfuction is one of the main reasons for perinatal mortality and a case rate at the present stage. Use of the algorithm of diagnostic and treatment-and-prophylactic actions improved by us allows major factors of risk of this complication and the indication for change of tactics and delivery times. Key words: decompensation placental dysfunction, diagnostics, delivery tactics.
News the treatment of vaginal microbiota in perimenopausal period
Authors:   Dnepropetrovsk State Medical Academy, Dnepr, Ukraine, Dubossarska Z.M.
Published: November 2020

The aim of the research: to evaluate the clinical efficacy and prevention of relapses of inflammatory and degenerative processes of the vagina in patients in perimenopausal period with the drug Femheal. Materials and methods. The study included 40 women aged from 49 to 56 years in perimenopausal period with clinical and laboratory confirmation of nonspecific vulvovaginitis and degenerative processes of the vagina: held pH meter before the appointment of therapy Femheal, 7 days and 3 months after the application Femheal. According to the severity of menopausal disorders to treatment included menopausal hormonal therapy, lipid-lowering and antihypertensive drugs. Results. The use of complex therapy with the use Femheal helps to restore the vaginal microbiota, which is accompanied by disappearance of clinical manifestations nonspecific vulvovaginal (feeling pain in the abdomen, in the genitals, itching, burning, swelling, discomfort and disperion), by normalization of pH. This therapy was effective in the prevention of recurrence, and with an integrated approach to reproductive aging - improving the quality of life. Conclusion. Practicing obstetrician-gynecologists, introducing the pathogenesis of chronic nonspecific vulvovaginal and related violations, especially in a situation when the pathological condition has completely pathognomonic clinical and laboratory evidence, should exclude bacterial vaginosis, sexually transmitted infections, timely identification of changes in the vaginal environment through pH test. Given the high efficiency Femheal in our study and documented in international publications relative to the positive evaluation reattain of action of the drug in the complex treatment of nonspecific vulvovaginitis and prevention of their recurrence, recommended his application for restoration of the vaginal biotope. Key words: nonspecific vulvovaginitis, perimenopausal period, Femheal.
A paradigm shift in the concept of arrhythmogenic cardiomyopathy: expanding the clinical and genetic spectrum, new diagnostic criteria for left ventricular phenotypes
Authors: Vaikhanskaya T. G. , Sivitskaya L. N. , Kurushko T. V. , Rusak T. V. , Levdansky O. D. , Danilenko N. G. , Davydenko O. G.
Published: November 2020

Recent multicenter studies using high-tech cardiac imaging and novel translational technologies have shown that cardiac fibrofatty replacement, characteristic of arrhythmogenic cardiomyopathy (ACM), is observed in both ventricles; left ventricular (LV) involvement may be minimal, on par with the right ventricle (RV), or dominant. In 2019, the Heart Rhythm Society (HRS) proposed a new approach to the assessment of arrhythmic and genetic diseases with the inclusion of new phenotypes — left-dominant ACM and biventricular ACM. In 2020, to improve the diagnosis of left ventricular phenotypes, European experts revised ACM criteria (based on the 2010 ITF criteria), which are called the Padua criteria.

The presented article highlights the clinical and genetic aspects of the new concept and the difficulties in ACM diagnosis, the practical experience of using new diagnostic algorithm. To help practitioners, step-by-step differential diagnosis and risk stratification of right and left ventricular phenotypes are presented using clinical examples (leftdominant ACM with a pathogenic variant in the LMNA gene; right-dominant ACM associated with a desmoplakin gene mutation, with predominant RV and moderate LV involvement; and an isolated RV ACM associated with a mutation in the plakophilin 2 gene).
Next generation sequencing in sudden cardiac death (pilot study)
Authors: Maksimov V. N. , Ivanoshchuk D. E. , Orlov P. S. , Ivanova A. A. , Malyutina S. K. , Maksimova S. V. , Rodina I. A. , Khamovich O. V. , Novoselov V. P. , Voevoda M. I.
Published: November 2020

Aim.To search for causal mutations in candidate genes responsible for the development of sudden cardiac death (SCD) in men who died under the age of 45.

Materialandmethods.The SCD group (n=37) was formed using the criteria the World Health Organization and the European Society of Cardiology. Autopsy material was collected from men who died suddenly outside medical institutions and underwent forensic medical examination according to the standard protocol. Autopsy revealed no morphological changes that could explain sudden death. The mean age was 32,4±6,4 years. Genomic DNA was isolated from myocardial tissue using phenol-chloroform extraction. Clinical exome sequencing was performed. At first, we analyzed the results of sequencing of 24 genes, mutations in which lead to cardiovascular diseases associated with an increased risk of SCD:KCNQ1,KCNH2,SCN5A,AKAP9,ANK2,CACNA1C,CALM1,CALM2,CAV3,KCNE1,KNCJNE2,KCNE2,SCN4B,SNTA1,MYH2,APOB,KCNA5,TGFB3,NEB,PDX1,FLNC,PLEC,KCND3.

Results.Of 37 samples, we revealed 13 probable pathogenic missense mutations in 9 samples (24,3%). Of 13 probable pathogenic variants, 5 were new.

Conclusion.This pilot study provides following conclusions: it is necessary to continue molecular autopsy research in Russia; to increase the effectiveness of detecting causal mutations, it is necessary to reduce the age of patients with SCD included in the study; studying the families of deceased; cooperation of experienced specialists — forensic pathologist, laboratory geneticist, cardiologist.
Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure
Authors: Pecherina T. B. , Kutikhin A. G.
Published: November 2020

Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice.
TExpression of matrix metalloproteinases 1, 2, 9, 12 in xenogenic tissues of epoxy-crosslinked bioprosthetic heart valves explanted due to dysfunction
Authors: Kostyunin A. E. , Glushkova T. V.
Published: November 2020

Aim. To study the expression patterns of matrix metalloproteinases (MMPs) -1, -2, -9, -12 in the leaflets of the epoxy-treated bioprostheses explanted due to dysfunction and to identify the pathways for the accumulation of these enzymes in the xenogenic tissues.

Methods. 19 leaflets from seven epoxy-treated bioprostheses (Kemcor (n = 2), PeriCor (n = 2), UniLine (n = 2) and TiAra (n = 1)) explanted from the mitral or aortic positions during repeat heart valve replacements were included in a study. Sections for microscopic studies were cut on a standard rotary microtome. Cell typing and the expression of MMP-1, -2, -9, -12 were evaluated using immunohistochemical staining with the antibodies against PTPRC/CD45, CD68, neutrophil myeloperoxidase and the corresponding MMPs. Stained samples were examined by light microscopy.

Results. Sporadic cell infiltrates, mainly composed of macrophages (PTPRC/CD45+, CD68+), were found in 17 leaflets from six explanted bioprostheses. Positive staining for MMP-1, -2, -9, -12 was colocalized with immune cell infiltrates. It is worth noting that MMP-9 staining was visualized even in the absence of cell infiltration, while more intense staining was found in the areas with a loose extracellular matrix. There were no signs of macrophage infiltration or MMP expression in xenotissues of pericardial bioprostheses failed due to thrombosis and explanted two days after implantation. However, a blood clot formed on its surface showed intense MMP-9 staining and included a large proportion of neutrophils positive for myeloperoxidase.

Conclusion. Macrophages and other immune cells that infiltrate xenotissues of epoxy-treated bioprostheses are sources of MMP-1, -2, -9, -12. In addition, MMP-9 can diffuse into bioprosthetic valve leaflets from blood plasma of patients. Thus, MMPs deposition in xenotissues may contribute to the leaflet ruptures and calcifications leading to the development of bioprosthetic valve dysfunction.
Prevalence of geriatric syndromes in persons over 65 years: the first results of the EVCALIPT study
Authors: Tkacheva O. N. , Vorob’eva N. M. , Kotovskaya Yu. V. , Ostroumova O. D. , Chernyaeva M. S. , Silyutina M. V. , Chernov A. V. , Testova S. G. , Ovcharova L. N. , Selezneva E. V.
Published: November 2020

Aim.To study the prevalence of geriatric syndromes and assess their relationship with senile asthenia in persons aged ³65 years living in Russian regions with different demographic, climatic and socio-economic characteristics.

Material and methods.We examined 664 patients aged 65-107 years (mean age, 79±9 years; men, 25%) living in Moscow (n=365) and Voronezh (n=299). All patients underwent a comprehensive geriatric examination, which consisted of two stages: a survey with original questionnaire and an objective examination.

Results.The prevalence of senile asthenia was 66,4%, including 47,4% in people aged 65-74, 71,1% — 75-84 years, and 82,8% — ³85 years (p for trend <0,001). Senile asthenia was associated with age (odds ratio (OR), 2,36; 95% confidence interval (CI), 1,89-2,93; p<0,001) and female sex (OR, 1,52; 95% CI 1,06-2,18; p=0,024). Patients with senile asthenia had a lower socioeconomic status. Also, close associations of senile asthenia with other geriatric syndromes (dementia, depression, vision and hearing impairment, incontinence, falls, high risk of falls, functional decline, failure to thrive) with OR from 1,32 to 7,22 were revealed.

Conclusion.The first results of the EVCALIPT study indicate a high incidence of senile asthenia in persons aged ³65 years and its close association with other geriatric syndromes and socio-economic factors.
Prospects for the implementation of a bachelor’s degree in medicine
Authors: Sirotkina O. V. , Ischuk T. N. , Golubeva I. S. , Parmon E. V. , Shlyakhto E. V.
Published: November 2020

According to modern healthcare requirements, it is necessary to increase workforce capacity of primary care practice, therefore, improving the specialist training is one of the high-priority problems of medical education. Not enough attention is paid to paramedic education and their role in Russian healthcare. The presented analysis of the paramedic profession history and the current state of high-quality healthcare in Russia shows the need to create a regulatory basis for the training of paramedics in the higher education system — a bachelor’s degree.
Satellite applications in diamond exploration and mine monitoring
Authors: Steenkamp N.C. , Goosen S.L. , Bouwer P.J.
Published: November 2020

SYNOPSIS Satellite-based applications for the monitoring of diamond exploration, operational mines, and post-closure mine sites is gaining traction. A variety of imagery is used to detect both kimberlite and alluvial deposits. Hyperspectral data is utilized mainly for primary deposits, and elevation models for secondary deposits. The data is used to constrain the exploration and ground truthing efforts, resulting in savings on both cost and time. Operational mines benefit from near-real-time monitoring of mining and related activities, including include environmental and security aspects. Satellite imagery can also be used to detect illegal and artisanal diamond diggings, with particular value for ethical sourcing validation in the supply chain. Post-closure monitoring of dumps and rehabilitation reduces the on-site presence of staff. The limitations of satellite applications are related mainly to the cost of obtaining images and the resolution or number of bands available on a detection platform. Keywords: remote sensing, satellite, monitoring, diamond, exploration, kimberlite, alluvial.
Next-generation, affordable SO2 abatement for coal-fired power generation - A comparison of limestone-based wet flue gas desulphurization and Sulfacid® technologies for Medupi power station
Authors: Strickroth A. , Schumacher M. , Hasse G.W. , Kgomo I.
Published: November 2020

SYNOPSIS Coal is used to generate more than three-quarters of South Africa's electricity, while numerous coal-fired boilers are employed for steam generation in industrial processes. However, coal-fired power generation is responsible for the release of the largest quantities of SO2 emissions to the atmosphere and leads to detrimental health and welfare effects in communities in the proximity of coal-fired plants. The classical industrial SO2 abatement solution for the coal-fired power generation industry is wet flue gas desulphurization, which uses a limestone adsorbent and produces a gypsum by-product (WFGD L/G). In South Africa, due to the poor quality of the limestone the gypsum product is unsaleable and is co-disposed with coal ash. In comparison, the Sulfacid® process technology converts SO2 contained in industrial flue gas into saleable sulphuric acid using a catalytic process requiring only water and air. This process does not require limestone. The scale of the latest commercial applications of the Sulfacid® SO2 abatement technology in the chemical, fertilizer, and copper mining industries demonstrates the potential and readiness of this technology to be employed in the coal-fired electricity and steam production sectors. This paper provides a first-order direct comparison between the techno-economic aspects of the WFGD (L/G) and Sulfacid® technologies using the requirements specified for the 6 x 800 MWe Eskom coal-fired Medupi power station. The results indicate that affordable flue gas desulphurization technology exists that could be adopted by the South African industry to reduce SO2 emissions to legislative limits and beyond. Keywords: SO2 abatement, coal-fired power, and heat generation, sulphuric acid, wet fluidized gas desulphurization, Sulfacid®, waste-to-chemicals.
Construyendo el tercer espacio en la formación inicial del profesorado. Una experiencia práctica desde el enfoque de los fondos digitales de conocimiento e identidad
Authors: Gutiérrez-Cabello Barragán Aingeru
Published: November 2020

The initial teacher training needs more inclusive approaches to allow a coherent articulation between theory, practise and recognition of identity and knowledge of students. The purpose of this article is to explore the fund of knowledge and identity of a student at the University of the Basque Country on his training period. Furthermore, we analyse the relations created between his biographical elements and his teaching practice at school during his traineeship. We study different strategies to enable the building of third space (Bhabha, 1994; Gutiérrez, 2008), strengthening university-school relationship. The development of this experience has allowed us to discover the educational possibilities offered by a change in the epistemology of teacher training, to establish a better relationship between personal and professional areas of students, and academic and practical dimensions during their training.