bluuebunny/crossref_metadata_2025 huggingface dataset:
Fatores associados à injúria renal aguda em pessoas idosas com covid-19 no período pré-vacinação: um estudo de coorte
Authors: Maciel Camilla de Godoy , Cavalcanti Belvania Ramos Ventura da Silva , Ferreira Aline Bezerra , Vasconcelos Eliane Maria Ribeiro de , Borba Anna Karla de Oliveira Tito
Published: January 2025

Resumo Objetivo analisar a incidência de injúria renal aguda e os fatores associados em pessoas idosas com covid-19 no período pré-vacinação. Métodos estudo de coorte retrospectivo, realizado com 137 indivíduos, com idade igual e superior a 60 anos e diagnóstico confirmado de covid-19, internados em hospital público, na cidade do Recife, Pernambuco, Brasil, no período de abril de 2020 a abril de 2021. Os dados foram analisados por meio da estatística descritiva, inferencial e análise de regressão logística multivariada. Resultados a injúria renal aguda ocorreu em 36,3% das pessoas idosas com covid-19, sendo 45,5% homens, com predomínio de indivíduos com 70 anos ou mais. Foi observada uma incidência de 61,2% de pacientes necessitando de hemodiálise, dos quais 70,2% não recuperaram a função renal e 63,3% faleceram. Na análise multivariada, a injúria renal aguda foi associada à doença renal crônica no estágio conservador [OR 8,59 (1,33-55,32), p=0,024], internação em unidade de terapia intensiva [OR 3,71 (1,10-12,53), p=0,034] e uso de drogas vasoativas [OR 7,07 (2,41-20,79), p<0,001]. Conclusão a identificação das variáveis envolvidas nesse processo e a implementação de estratégias são fundamentais para otimizar o diagnóstico oportuno e medidas de tratamento a fim de dirimir a ocorrência de disfunção renal e de suas potenciais complicações.
Fatores associados à readmissão em até 30 dias em pessoas idosas: estudo de caso-controle
Authors: Sanseverino Amanda Xavier , Garcia Yanka Eslabão , Santos Mariana Timmers dos , Lima Maria Alice Dias da Silva , Acosta Aline Marques
Published: January 2025

Resumo Objetivo Analisar os fatores de risco associados à readmissão hospitalar de pessoas idosas em até 30 dias. Método Trata-se de estudo retrospectivo, do tipo caso-controle. Participaram 568 pacientes que tiveram alta de unidades de internação de hospital no Sul do Brasil, sendo 284 casos (que readmitiram após a alta) e 284 controles (que não readmitiram). Os dados foram coletados por meio de consulta aos prontuários eletrônicos e foram analisados utilizando-se análise bivariada e regressão logística multivariada. Resultados Variáveis relacionadas a motivo da admissão, comorbidades, histórico de internação no ano anterior, admissão pela emergência, tempo de permanência e tipos de orientações para alta tiveram diferenças significativas (p<0,05) entre os grupos na análise bivariada. Na regressão logística multivariada, identificaram-se como fatores protetores: motivo de admissão por doenças infecciosas/parasitárias (p=0,007) e comorbidades categorizadas como “outros” (p<0,001). Como fatores de risco, identificaram-se: motivo de admissão por neoplasias (p<0,001), comorbidades geniturinárias (p=0,028), histórico de internação no ano anterior (p<0,001), admissão pela emergência (p=0,016), tempo de permanência na admissão em dias (p<0,001), e orientação de alta de retorno para procedimento ambulatorial ou cirúrgico (p=0,008). Conclusão Evidenciam-se fatores de risco clínicos e organizacionais associados à readmissão em até 30 dias em pessoas idosas, os quais merecem atenção ao se planejar ações de transição do cuidado.
Which is the shear force that defines the lamb's sensory acceptance?
Authors: Battagin Heloísa Valarine , Rocha Yana Jorge Polizer , Gotardo Luciana Ruggeri Menezes , Oliveira Letícia Zanichelli de , Gonçalves Letícia Aline , Ganeco Aline Giampietro , Cardoso Susana , Moreira Ricardo Targino , Guimarães Judite Lapa , Gallo Sarita Bonagurio , Trindade Marco Antonio
Published: January 2025

Abstract The lamb meat tenderness acceptance threshold has been little studied and has never been evaluated for the Brazilian population. So, this study aimed to find the maximum acceptable shear force for Brazilian lamb meat consumers. Three muscles were previously tested and chosen Longissimus thoracis et lumborum (LTL), psoas major and semimembranosus muscles received different treatments in the post-slaughter period (Hot deboning followed by cooling on ice, Standard carcass cooling and Ageing), aiming to create samples with varying levels of tenderness, which were evaluated by acceptance tests and descriptive analysis of tenderness by a trained team. Sarcomere length, myofibril fragmentation index, proximate composition, weight loss and pH analyses were performed to observe the biochemical phenomena in each treatment's meats. Variations caused in samples by treatments were more significant than differences inherent to the different muscles. Pearson and Multiple Factor correlation analyses indicated positive correlations between sarcomere length, myofibril fragmentation index and the scores assigned in sensory tests by 140 panelists and a trained team. Both groups noted that the differences between the meats in terms of tenderness and the sarcomere length also influenced the perception of juiciness observed by the groups. The maximum shear force indicated as acceptable for lamb meat was 44.1 N. The results obtained are important to guide the lamb meat producer for certain practices in the post-slaughter moments, avoiding actions that lead to sarcomere shortening and encouraging the production of aged meats.
CO2 emission in soil under eucalyptus cultivation with biochar application
Authors: Silva Chansislayne Gabriela da , Passos Renato Ribeiro , Santos Danilo Andrade , Mendonça Eduardo de Sá , Machado Lorena Contarini
Published: January 2025

ABSTRACT The use of biochar to fix carbon in the long term has become promising for reducing CO2 emissions, with eucalyptus bark being an excellent source of raw material for its production. This study aimed to evaluate the effect of applying eucalyptus bark biochar on soil CO2 emissions, in an area planted with eucalyptus. A randomized block design, with a 2 x 5 factorial scheme, was used, encompassing two pyrolysis temperatures (350 and 600 ºC) and five biochar doses (0, 0.625, 1.25, 2.5 and 5 Mg ha-1), with three replications, where the doses corresponded to 25 % of the dose used at planting. The soil CO2 emissions, humidity and temperature were measured at 90, 97, 105, 112, 120 and 127 days of surface application of biochar. The 5 Mg ha-1 dose contributed to reduce the accumulated CO2 emissions by 65 and 24 %, respectively for the pyrolysis temperatures of 350 and 600 ºC, when compared to the 0 Mg ha-1 dose, thus contributing to mitigate emissions and support agricultural and environmental sustainability. In order to reduce the CO2 flow, the period indicated for its application is when the soil temperature is higher and the soil humidity is lower.
Silicon as a salt stress mitigator in yellow passion fruit seedlings
Authors: Almeida Cristóvão Jacques de Sousa , Dantas Jussara Silva , Mesquita Evandro Franklin de , Sousa Caio da Silva , Soares Vitória Carolina da Silva , Diniz José Paulo Costa , Pereira Rennan Fernandes , Lins Lays Klécia Silva , Nogueira Virgínia de Fátima Bezerra , Silva Filho Irinaldo Pereira da
Published: January 2025

ABSTRACT In the Brazilian semi-arid region, the production of passion fruit seedlings often faces challenges such as irrigation with saline water. However, silicate fertilization stands out as an effective solution for mitigating the salinity effects. This study aimed to evaluate the use of silicon as a salt stress mitigator in yellow passion fruit seedlings, under greenhouse conditions. The experimental design was completely randomized, with six replications, in a 5 × 2 factorial scheme, referring to five silicon doses (0, 0.25, 0.50, 0.75 and 1.0 g plant-1) and two electrical conductivity levels of the irrigation water (1.2 and 3.5 dS m-1). Variables related to plant growth, biomass and physiology were analyzed. Silicon doses between 0.50 and 0.60 g plant-1 provided the best results for the passion fruit seedlings’ growth, water status and physiology, both under lower (1.2 dS m-1) and higher (3.5 dS m-1) salinity conditions. The silicon strengthened the plants and improved water absorption, mitigating the negative effects of salinity on the yellow passion fruit.
Bem Viver e Gestão Social: em Busca de um Diálogo Descolonial no Campo dos Estudos Organizacionais
Authors: Cunha Eduardo Vivian da , Sousa Washington José de
Published: January 2025

Resumo Costuma-se apontar a necessidade da construção de um pensamento brasileiro e latino-americano próprio em contraposição ao pensamento eurocêntrico, colonial. Sob essa premissa, é nosso objetivo, neste artigo, suscitar reflexões acerca da descolonialidade pela via da conciliação entre práticas e ideias de Bem Viver – na concepção original equatoriana – e atributos de Gestão Social. Tal reflexão é realizada com a mediação de referenciais provenientes, principalmente, de debates latino-americanos sobre descolonialidade e Bem Viver e brasileiros em torno dos estudos organizacionais críticos e gestão social. Sintetizamos, assim, confluências e divergências em torno de visões de mundo construídas, contemporaneamente, a partir do pensamento indígena do Bem Viver e que são compartilhadas pela Gestão Social. Como resultado do exercício realizado, visualizamos aproximações entre a cosmovisão enfeixada pelo Bem Viver e aquela derivada do debate brasileiro em torno da Gestão Social, todavia, com diferenças circunscritas a aplicações em períodos de tempo e contextos distintos, bem como em algumas premissas epistemológicas. Consideramos que a inclusão do debate descolonial no escopo da Gestão Social pode ajudar a alargar seu horizonte de compreensão e de atuação, sem prejuízo ou substituição da construção já realizada até o momento. Propomos, ao final, uma agenda de pesquisa para aprofundamento do debate.
Potentially paraneoplastic glomerulopathies in a Brazilian cohort: a retrospective analysis
Authors: Laferreira Marcella Soares , Kirsztajn Gianna Mastroianni
Published: January 2025

Abstract Introduction: Glomerular diseases can be associated with solid or hematopoietic malignancies. The prevalence of these associations varies according to the studied glomerular disease. This study aimed to evaluate the frequency and type of neoplasms in patients with glomerular diseases as well as their clinical, laboratory, and histopathological features and the relationship with immunosuppressive therapy. Methods: This was a retrospective, descriptive, observational, longitudinal study that reviewed 4,820 medical records and included 95 patients with glomerular disease and neoplasms. Demographic, clinical, laboratory, and histologic data were collected. Results: The prevalence of neoplasms was 1.97% (95 patients; 81 [85.3%] malignant, 14 [14.7%] benign). Hematologic malignancies (35.8%) showed the highest prevalence, followed by colon, rectal, and gynecologic tumors. The glomerulopathy with the highest frequency was membranous glomerulopathy (MGN, 25 patients, 35.7%). The dose of the immunosuppressive agents among patients with neoplasms before or after immunosuppression was not statistically different. Neoplasm was diagnosed before glomerulopathy in 53% of patients. Among cases in which neoplasms were diagnosed after glomerulopathy, 43% were diagnosed in the first year of follow-up of the renal disease. The predominant syndrome at presentation was nephrotic syndrome. Progression to chronic kidney disease stage 5 at the end of follow-up occurred in 8.4% of the cases. Conclusions: Neoplasms manifested before or, less frequently, after the diagnosis of glomerular diseases. As neoplasms diagnosed after presentation of glomerulopathy often appeared early after this diagnosis, it is necessary to be aware of neoplasms during the first year of follow-up of glomerulopathies, especially in patients with nephrotic syndrome, and MGN.
Glomerulopatias potencialmente paraneoplásicas em uma coorte brasileira: análise retrospectiva
Authors: Laferreira Marcella Soares , Kirsztajn Gianna Mastroianni
Published: January 2025

Resumo Introdução: Doenças glomerulares podem estar associadas a malignidades sólidas ou hematopoiéticas. A prevalência dessas associações varia conforme a doença glomerular estudada. O objetivo deste estudo foi avaliar frequência e tipo de neoplasias em pacientes com doenças glomerulares, bem como suas características clínicas, laboratoriais e histopatológicas e a relação com a terapia imunossupressora. Métodos: Estudo retrospectivo, descritivo, observacional e longitudinal que analisou 4.820 prontuários e incluiu 95 pacientes com doença glomerular e neoplasias. Foram coletados dados demográficos, clínicos, laboratoriais e histológicos. Resultados: A prevalência de neoplasias foi 1,97% (95 pacientes; 81 [85,3%] malignas, 14 [14,7%] benignas). As malignidades hematológicas (35,8%) apresentaram maior prevalência, seguidas por tumores de cólon, reto e ginecológicos. A glomerulopatia com maior frequência foi a glomerulopatia membranosa (GM, 25 pacientes, 35,7%). A dose dos agentes imunossupressores entre pacientes com neoplasias, antes ou após a imunossupressão, não foi estatisticamente diferente. A neoplasia foi diagnosticada antes da glomerulopatia em 53% dos pacientes. Entre os casos em que as neoplasias foram diagnosticadas após a glomerulopatia, 43% foram detectadas no primeiro ano de acompanhamento da doença renal. A síndrome predominante na apresentação foi a síndrome nefrótica. A progressão para doença renal crônica estágio 5 ao final do acompanhamento ocorreu em 8,4% dos casos. Conclusões: Neoplasias se manifestaram antes ou, menos frequentemente, após o diagnóstico de doenças glomerulares. Como as neoplasias diagnosticadas após a apresentação da glomerulopatia frequentemente surgem logo após esse diagnóstico, é necessário atenção às neoplasias durante o primeiro ano de acompanhamento das glomerulopatias, especialmente em pacientes com síndrome nefrótica e GM.
Apoio social e garantia de equipamentos de proteção individual para profissionais de enfermagem na COVID-19
Authors: David Helena Maria Scherlowski Leal , Silva Tarciso Feijó da , Faria Magda Guimarães de Araújo , Miranda Rogério Bittencourt de , Duarte Rafael Bezerra , Silva Maria Rocineide Ferreira da
Published: January 2025

Resumo Objetivo analisar as redes de apoio social entre profissionais de enfermagem para garantir o acesso a equipamentos de proteção individual durante a pandemia de COVID-19, em dois municípios brasileiros. Método estudo transversal realizado com 163 profissionais de enfermagem do Rio de Janeiro e de Fortaleza cuja coleta de dados ocorreu no ano de 2020, por meio de um questionário on-line. Os dados foram analisados utilizando-se a Análise de Redes Sociais com o software Gephi. Resultados administradores e enfermeiros chefes desempenharam papéis centrais nas redes de apoio social, assegurando o acesso aos equipamentos de proteção individual. No entanto, foram identificadas lacunas, como a ausência de categorias profissionais, como biólogos, nutricionistas e médicos pneumologistas, o que indica possíveis falhas na comunicação ou na colaboração entre diferentes setores. Conclusão e implicações para a prática redes de apoio social estruturadas são essenciais para a proteção dos profissionais de saúde em situações de crise. As lideranças devem ser fortalecidas e uma maior integração entre categorias profissionais deve ser promovida. Programas de capacitação e políticas institucionais que incentivem a colaboração e o apoio mútuo são essenciais para melhorar a capacidade de resposta a emergências e garantir a segurança dos profissionais de saúde.
Modelling and Neuro-Adaptive Robust Control Algorithms for Solid Fuel Rockets
Authors: Carvalho Christian Danner Ramos de , Fonseca Neto João Viana da
Published: January 2025

ABSTRACT This study presents the development of a methodology for designing neuro-adaptive robust controllers based on a reference model associated with an artificial neural network of radial basis functions (ANN-RBF) for solid fuel suborbital rockets. The modelling and neuro-adaptive robust control algorithms for these rockets are presented. Initially, the methodology is evaluated for a robust controller based on a reference model with ANN-RBF for altitude control. The main objective of the control is to suppress the effect of non-linear uncertainties inherent in the process. The method involves mathematical and computational modelling, together with the design of adaptive controllers for stability and performance analysis. The controllers considered include model reference adaptive control (MRAC) techniques and a model reference neuro-adaptive control (MRNAC) approach. The analysis, carried out using computer simulations, evaluates the behavior of each controller in relation to system stability and performance. The final objective is to select the most suitable controller for the suborbital rocket, taking into account the system constraints, robust performance requirements, robust stability, and optimal adaptability. This research promotes the development of adaptive controllers for suborbital rockets, with possible applications in scientific research and commercial launches.
Ética, inclusão e Interculturalidade em Educação
Authors: Lins Maria Judith Sucupira da Costa
Published: January 2025

Resumo O problema que motiva esse artigo é a confusão concernente aos significados dessas três palavras: Ética, Inclusão e Interculturalidade. São categorias de diferentes áreas, mas observamos que são usadas erroneamente como instâncias similares. Partimos do pressuposto que Inclusão e Interculturalidade são dependentes de Ética. Ética, que é um dos três ramos da Filosofia, (Estética e Lógica são os outros dois) é necessariamente a base para as ideias e práticas de Inclusão e Interculturalidade. Ética não se encontra no mesmo nível epistemológico de ambas as palavras. O objetivo é explicar cada um dos conceitos, a relação entre Ética, Inclusão e Interculturalidade e como Inclusão e Interculturalidade necessitam da Ética para que se tornem realidade. A abordagem metodológica é a hermenêutica, que oferece a possibilidade de compreensão dentro da perspectiva lógica. A fundamentação teórica está principalmente no pensamento aristotélico. Concluímos que Inclusão e Interculturalidade são essenciais para a vida humana e dependem da Ética.
The Effect of Detethering Surgery on the Bladder Function and Psychology of Children with Primary Tethered Cord Syndrome
Authors: Yang Shuai , Zhou Zhaokai , Liu Xingchen , Wang Zhan , Zhang Yanping , Zhang He , Lv Lei , Wen Yibo , Wang Qingwei , Jia Wei , Hu Jinhua , Wen Jian Guo
Published: January 2025

ABSTRACT Purpose: Currently, detethering surgery (DS) is the modality most extensively utilized to treat primary tethered cord syndrome (TCS). Disappointingly, some children without bladder impairment showed a deterioration of bladder function after surgery, which critically influences the health-related quality of life. It was hypothesized that the DS might have a significant effect on bladder function and psychology. Therefore, the purpose of this study was to investigate the effect of DS on bladder function and quality of life in children with primary TCS. Materials and Methods: A retrospective study of 83 patients aged 6 to 10 years who were diagnosed with TCS and underwent DS between 2022 and 2023. The urodynamic parameters and score, psychological-behavioral profile, and lower urinary tract symptoms were compared before and after DS. Additionally, the patients were divided into the normal group and the abnormal group according to the preoperative urodynamics parameters. Results: A total of 66 children fulfilled the criteria, with a mean age at surgery of 89.5 ± 13.7 months. There were statistically significant differences in bladder detrusor sphincter synergy and urodynamic score and no statistically significant difference in the remaining urodynamic parameters and psychological-behavioral items before and after DS. The proportion of bladder dysfunction that improved or did not worsen after surgery was higher in the Abnormal group than in the Normal group. Nevertheless, the detection rate of each psychological behavior abnormality in children with TCS was higher compared with that of normal children, both preoperatively and postoperatively. Conclusions: DS could not considerably ameliorate pre-existing bladder dysfunction and patients exhibiting non-progressive bladder dysfunction could be treated conservatively with close observation. TCS plagues patients all the time even if detethering. Psychological counseling for children with TCS should be strengthened after DS.
Comparison of Morphological and Functional MRI Assessments of Periprostatic Fat for Predicting Prostate Cancer Aggressiveness
Authors: Vieira David Freire Maia , Torres Cecília Vidal de Souza , Secaf André de Freitas , Palma Matheus de Moraes , Gouvea Gabriel de Lion , Júnior Jorge Elias , Reis Rodolfo Borges , Muglia Valdair
Published: January 2025

ABSTRACT Purpose: The objective of this study was to evaluate whether morphological (linear measurements) and functional (ADC value) assessments of periprostatic fat can predict the aggressiveness of prostate cancer (PCa) over a 5-year follow-up period. Material and Methods: This retrospective study included patients with histologically proven PCa who underwent 3.0T MRI between July 2016 and June 2018. Clinical and demographic data collected included PSA, PSA density (dPSA), ISUP grade, clinical and pathological staging, and treatment details. MRI-derived parameters were assessed by an experienced radiologist, who measured subcutaneous and periprostatic fat thickness, and calculated ADC values from ROI plots in periprostatic fat. Clinical and MRI parameters were analyzed for associations with biochemical recurrence, systemic metastasis, and PCa-related mortality. Results: After applying exclusion criteria, 109 patients were included. Using the Cox model, dPSA (p<0.01), systemic disease at diagnosis (p<0.01), and mean ADC (p<0.02) were independent predictors of overall survival (OS). For progression-free survival (PFS), only dPSA (p<0.01) and systemic disease at diagnosis (p<0.01) were significant predictors. In the Poisson Model for systemic recurrence risk, dPSA had a relative risk (RR) of 1.04 (95%CI 1.0-1.07, p=0.03), systemic disease at diagnosis had an RR of 63.3 (95%CI 3.7-86.4, p<0.01), and average ADC had an RR of 3.42 (95%CI 1.52-7.69, p<0.01). Conclusions: The ADC value of periprostatic fat may serve as an additional tool for PCa risk stratification, correlating with poorer outcomes such as systemic recurrence and overall survival. If validated by external, prospective, multicenter studies, these findings could impact future therapeutic decisions.
The Management of Children and Adolescents with Overactive Bladder Refractory to Treatment with Parasacral Transcutaneous Electrical Nerve Stimulation
Authors: Macedo Carlos Eduardo Rocha , Braga Antônio Vitor Nascimento Martinelli , Marimpietri Felipe Santos , Argollo Beatriz Paixão , de Abreu Glicia Estevam , da Fonseca Maria Luiza Veiga , Braga Ana Aparecida Nascimento Martinelli , Barroso Jr. Ubirajara
Published: January 2025

ABSTRACT Background: Although parasacral TENS (pTENS) has been employed in various centers, there is a lack of studies on how children with overactive bladder (OAB) respond after failing to complete pTENS sessions. This study aimed to describe and assess treatments for OAB in children who did not respond to pTENS. Material and Methods: This retrospective case series examined patients aged 4-17 years. Patients were given subsequent treatment options, including: behavioral therapies; oxybutynin; imipramine; a combination of oxybutynin and imipramine; parasacral percutaneous electrical nerve stimulation (PENS); or a repeat course of pTENS. Outcomes were evaluated using the Dysfunctional Voiding Scoring System (DVSS) and the Visual Analogue Scale (VAS). Results: Thirty children were included, with a median age of 7 years. Patients received one or more treatments. Of these, 70% underwent monotherapy. Among them, 57% experienced complete resolution of symptoms, 28% had partial resolution and were satisfied with the results, and 14% discontinued treatment. 30% out of the whole sample continued to experience bothersome symptoms. Complete response, according to initial subsequent, was achieved in: 54% with intensified behavioral therapies, 33% with oxybutynin, and 50% with imipramine alone. The median DVSS score decreased from 7.0 to 2.0 (p=0.025), while the median VAS score increased from 80 to 100 (p<0.001). Conclusion: Children with OAB refractory to pTENS who received structured subsequent treatments showed partial response in all cases, with complete symptom resolution in half of the patients. More intensive urotherapy, medications, or repeat pTENS in combination with oxybutinin can be effective for managing this challenging condition.
Comparative Study of Gleason 7 (3+4) and (4+3) Prostatic Adenocarcinomas with Prognostic Criteria and Immunohistochemical Profiles of AMACR, PSA and Ki-67
Authors: Osório Clarice F. E. M. , Costa Waldemar S. , Gallo Carla B. M. , Favorito Luciano A. , Sampaio Francisco J. B.
Published: January 2025

ABSTRACT Background: To compare Gleason 7 (3+4) and (4+3) prostatic adenocarcinoma (PC) with different prognostic criteria through immunohistochemical analysis with anti-PSA, anti-Ki 67 and anti-AMARC antibodies. Methods: We analyzed 221 surgical specimens from patients between 40 and 86 years-old (mean=63) with PC. The immunohistochemical study was performed with anti-PSA, anti-Ki 67 and anti-AMARC. The microscopic fields were photographed with an Olympus DP70 digital camera coupled to an Olympus BX51 microscope and archived in TIFF. Proportion and intensity criteria were used to quantify the anti-PSA antibody and for the anti-Ki 67 antibody, the quantification by similarity of this antibody in breast carcinomas. Anti-AMACR protein expression was based on four scores: negative, weak, moderate and strong. The statistical analysis was performed with the Graph Pad Prism 5 program. Results: In the Gleason score 7 (3+4) we had 91.72% in pT2 and 8.27% in the pT3 group; 8.27% recurrences, of which 90.90% in the pT2 group. In the Gleason score 7 (4+3) we had 77.27% in the pT2 group and 22.72% in the pT3 group and 10.22% of relapses, of which 66.66% in the pT2 group and 33.33% in the pT3 group. In 6.81% of cases there was an increase in the anti-Ki 67 index and in 2.27% of the cases, there was an increase in the immunoexpression of anti-p53 when comparing Gleason score 7 (3+4) with Gleason score 7 (4+3). Conclusion: Our study confirmed differences in the Gleason score 7 (3+4) and Gleason score 7 (4+3) of PC when comparing prognostic criteria. Anti-Ki 67 and anti-PSA antibody immunostaining showed a positive correlation as the Gleason score 7 increased from (3+4) to (4+3).
Sociodemographic factors of violent deaths related to licit or ilicit psychoactive substances: a cross-sectional study, Ceará, Brazil, 2015-2019
Authors: Holanda Júnior Wanderley Pinheiro de , Maceno Raimunda Hermelinda Maia , Ferreira Maria Augusta Drago
Published: January 2025

ABSTRACT Objective To assess association between sociodemographic factors, presence of licit or illicit psychoactive substances, and types of legal death in Ceará state, Brazil. Methods Cross-sectional study based on autopsy data and toxicology tests on victims of cases registered by the Ceará Forensic Expert service, from 2015 to 2019. Results Of the 4,198 cases analyzed, 55.6% were positive for licit and/or illicit substances, with greater frequency of benzodiazepines (22.4%) and cocaine (21.7%) among males (45.0%), young adults (58.7%), single people (49.0%), and those with low education levels (52.8%). Association was found between benzodiazepines (29.5%) and tricyclic antidepressants (15.6%) and suicides; cocaine (28.1%) and cannabis (27.1%) and homicides; and cocaine (28.2%) and tricyclic antidepressants (5.9%) and suspicious deaths. Conclusion Sociodemographic factors were associated with the use of psychoactive substances and types of legal death. Benzodiazepines and cocaine were the most frequent substances in suicide and homicide cases, respectively.
Criminal Procedure: Practical Applications
Authors:   Universidad Cooperativa de Colombia, Anaya Caraballo Liliana , Mogollón Anaya Nuby , Urzola Mestra Enrique Carlos
Published: January 2025

This class note aims to clarify the content and practical applications of the Criminal Procedure subject, and it will delve into matters related to its conceptualization, the importance of understanding the basic concepts of criminal law, criminal offenses, and their consequences. The theoretical part of criminal procedure, the fundamental principles of procedural criminal law, and their relationship with other areas of law will be analyzed. A conceptual characterization of the penal system, the normative hierarchy, and a detailed overview of the legal order in the Colombian penal regime will be developed, taking into account the current regulations. Finally, the aim is to provide a well-detailed outline of the topics to be covered in the Criminal Procedure course. Moreover, it will demonstrate how these contents can be practically applied in the legal field to resolve common situations encountered during the student’s academic journey.
Perspectivas tributarias y financieras en sectores estratégicos del Ecuador
Authors:   Universidad Politécnica Salesiana, Ecuador
Published: January 2025

En el dinámico panorama económico de Ecuador, los aspectos tributarios y financieros juegan un rol fundamental en el desarrollo del país y el bienestar de sus ciudadanos. El libro Perspectivas tributarias y financieras en sectores estratégicos del Ecuador ofrece una visión integral sobre cómo las políticas fiscales, la gestión empresarial y el cumplimiento de normas contables impactan en sectores clave de la economía nacional. Esta obra aborda, en cinco capítulos, temas esenciales como los beneficios fiscales para los adultos mayores, el impacto del Impuesto a la Salida de Divisas (ISD) en startups de comercio electrónico, y el cumplimiento de la NIC 16 en empresas agrícolas, ganaderas, silvícolas y pesqueras. También examina el efecto de la gestión de inventarios en la rentabilidad del sector farmacéutico y la relación entre liquidez y rentabilidad en las grandes empresas acuícolas y pesqueras. Dirigido a académicos, profesionales y gestores, este libro combina análisis crítico, iluminando los desafíos y oportunidades del entorno económico ecuatoriano. Al explorar cómo las políticas fiscales y financieras pueden promover la equidad social y el crecimiento sostenible, esta obra es una herramienta invaluable para comprender y fomentar el desarrollo del país.
Implicaciones sociales de los beneficios fiscales en adultos mayores
Authors:   Universidad Politécnica Salesiana, Baños Ortega Maikol , Guijarro Barahona Leslie ,   Universidad Politécnica Salesiana, Ecuador, Morales Ericka Issa ,   Universidad Politécnica Salesiana, Ecuador
Published: January 2025

En el Ecuador, los adultos mayores son uno de los sectores más vulnerables, por lo que el gobierno implementa políticas y beneficios fiscales para mejorar sus condiciones de vida. Según el artículo 5 de la Ley Orgánica de las Personas Adultas Mayores (LOPAM), se considera adulto mayor a toda persona de 65 años o más, según lo establecido en el Suplemento del Registro Oficial No. 484, del 9 de mayo de 2019.
The Hidden Legacy of 1968
Authors: Kempter Klaus
Published: January 2025

Conventional historical and political wisdom in Western Europe has it that therevolutionary aspirations of the 68ers failed – and that, paradoxically, this veryfailure constitutes their great success. The movements of ‘68 (to be moreprecise: their radical wings, whose picture dominates the historical memory inpublic images und cultural representations) more or less aimed at some kind ofanti-authoritarian, anarchist, later on also socialist/communist overthrow ofthe ruling order. The experience of Paris May 1968, for instance, seems to bemirrored in the catch-phrase “All Power to Imagination” (“L’immagination aupouvoir”).
Aligning Information Systems with Complex Work Environments
Authors:   , Nimley Kenneth , Rogers Michelle
Published: January 2025

The integration of case management information systems into complex work environments like child welfare services aims to enhance performance and support informed decision-making. However, despite case management information systems designed to improve efficiency and collaboration, caseworkers have a noticeable information deficit, highlighting significant challenges in adequately meeting their needs. This dissertation investigates a socio-technical information systems approach that informs users' dynamics in environments characterized by high complexity and variable information demands. Employing a mixed-methods approach, this research combines qualitative and quantitative techniques to explore challenges to the work process. Data was collected through surveys and semi-structured interviews with caseworkers, clinical supervisors, and program directors from a child welfare non-profit organization in Philadelphia, Pennsylvania. The study utilized Work Domain Analysis in conjunction with iStar modeling frameworks to systematically analyze the socio-technical landscape, uncovering stakeholders' information needs and the complex relationships influencing system interactions. Key findings of this dissertation research include (1) a detailed identification of specific information deficits, such as difficulties accessing real-time updates and dealing with fragmented data entries, (2) insights into how information deficits lead to inefficiencies and delays in impacting related and unrelated processes, and (3) a thorough examination of the broader implications for complex socio-technical system design, highlighting the need for adaptable interfaces and improved integration with workflows. This research introduces novel insights into the specific information deficits encountered by caseworkers and the broader implications for designing effective information systems. Additionally, the study expands the application of Work Domain Analysis and iStar modeling frameworks to complex socio-technical environments, providing new insights into stakeholder information needs and system interactions. In terms of practical impact, by bridging theory and practice, this work contributes to information system design by offering actionable guidance for improving case management information systems, focusing on user-centered design and the integration of technical and socio-cultural factors.
A CASE OF CHICKENPOX INFECTION FOLLOWING COVID-19 VACCINATION
Authors: Durusu İrem Nur , Gurel Gulhan
Published: January 2025

We are in the middle of Coronavirus disease 2019 (COVID-19) pandemic and to take control the disease burden several COVID-19 vaccines have been authorized and approved for distribution worldwide. Pfizer-BioNTech vaccine which is a nucleoside-modified RNA vaccine (BNT162b2 Comirnatry) is one of the most important and effective COVID-19 vaccines. As the number of vaccinated people increases, we see various cutaneous side effects related to vaccination. Delayed local reactions, morbilliform rashes, urticaria are among the most common side effects. Herein, a 38-year-old immunocompetent patient with second time experienced chickenpox infection developed immediately after the second dose of Pfizer-BioNTech vaccine is presented. With this case, we reviewed the fact that chickenpox disease is not supply a life-long immunity in all people, it can be re-triggered by some immune mechanisms related with vaccination.
BETA BLOCKER THERAPY IMPROVES RIGHT VENTRICULAR FUNCTIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Aksu Uğur , Aksu Deya , Aksakal Emrah , Sevil Fehim Can
Published: January 2025

OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a clinical condition with a high mortality and morbidity rate. Cardiac involvement is common in COPD patients. In this disease, beta-blocker (BB) treatment could not be used in sufficient doses most of the time since it is thought that this treatment may aggravate the disease. However, BB is the main drug therapy in patients with atherosclerotic heart disease. In this study, right ventricular (RV) functions were examined using speckle-tracking echocardiography in COPD patients under BB therapy.
MATERIAL AND METHODS: Patients, who were followed up with the diagnosis of COPD, were involved in the study. Patients under BB treatment for three months or more were assigned to Group 1 and patients with similar demographic and clinical features to the control group by using propensity score matching (PSM) analysis. Baseline demographic and clinical features of patients were compared, and the effects of BB treatment were analyzed.
RESULTS: After PSM analysis, right ventricular free-wall global strain (p <0.001), right ventricular global longitudinal strain (p <0.001), right ventricular right ventricular free-wall global strain rate (p: 0.001), and right ventricular global longitudinal strain rate (p: 0.005) were found to be significantly higher in Group 1.
CONCLUSIONS: COPD and atherosclerosis have similar pathways such as inflammation and endothelial dysfunction, and the use of BB in COPD patients may have a positive effect on the improvement of right ventricular functions. This effect can be demonstrated by making use of the deformation analysis rather than conventional parameters.
YOĞUN BAKIM ÜNİTESİNE ALINAN YENİDOĞAN BEBEKLERİN EBEVEYNLERİ: SOSYODEMOGRAFİK ÖZELLİKLERİ, STRES DÜZEYLERİ VE PSİKOPATOLOJİLERİ İLE İLGİLİ KARŞILAŞTIRMALI BİR ANALİZ
Authors: Çobanoğlu Osmanlı Cansu , Şahin Berkan , Hoşoğlu Esra , Önal Bedia Sultan
Published: January 2025

AMAÇ: Yenidoğan döneminde bebeklerin Yenidoğan Yoğun Bakım Ünitesi (YYBÜ)’ ne yatışları özellikle anne ve babaları için oldukça sancılı ve zorlu bir süreçtir. Çalışmamızda yenidoğan döneminde yoğun bakım yatışı olan bebeklerle, doğdukları andan itibaren anne-baba yanına verilen bebeklerin anne-baba stres düzeyleri ve ebeveyn psikopatolojilerini karşılaştırmayı amaçladık. Ayrıca anne babaların bu süreci daha iyi yönetebilmeleri adına değiştirilmesi ya da uygulanması gereken parametreleri belirlemek de amaçlarımız arasındadır.
GEREÇ VE YÖNTEM: : Ocak 2023 - Haziran 2023 tarihleri arasında üçüncü basamak bir sağlık kuruluşu YYBÜ’ne yatışı olan 43 bebeğin ebeveynleri ile yenidoğan ve direk anne yanına verilen 103 bebeğin ebeveynleri değerlendirmeye alınmış, kendilerine çalışmacılar tarafından hazırlanan Sosyodemografik Veri Formu, Anne-Baba Stres Ölçeği, Durumluk-Sürekli Kaygı Envanteri (STAI Form TX-I ve TX-II) ile Belirti Tarama Testi (SCL-90-R) doldurtulmuştur.
BULGULAR: YYBÜ grubu bebeklerin doğum haftası ve doğum kilosu medyanı kontrol grubuna göre daha düşük bulunurken (sırasıyla; p<0.001, p=0.038)annelerinin düşük doğum yapma öyküsü yüksek bulunmuştur (p=0.002). Ayrıca YYBÜ grubu bebeklerin babalarının çalışma durumu anlamlı düzeyde düşük bulunurken (p=0.022), babalarında fiziksel sağlık sorunu bulunma oranı yüksek bulunmuştur (p=0.017). YYBÜ grubu bebeklerin annelerinin SCL-90-Depresyon alt-skoru medyanı ile SCL-90-Kişilerarası duyarlılık alt-skoru medyanı yüksek bulunmuştur (sırasıyla; p=0.019, p=0.046).
SONUÇ: Babanın çalışmama ve fiziksel hastalığa sahip olma durumları ailenin ekonomik sürecini etkileyebileceğinden gebelik öncesi ve süresince gerekli takip ve kontrollerde aksaklıklar ile bebeğin sağlık sürecinin etkilenmesine sebep olabileceği, sonuçta YYBÜ için dolaylı bir risk faktörü olarak değerlendirilmiştir. Ayrıca YYBÜ’nde kalan bebeklerin annelerinde depresyon, kişiler arası duyarlılık gibi birtakım mental problemlerin de takibi önemlidir. Çalışmamız özellikle ailenin destek sisteminin güçlenmesinin, aile içi ekonomik güvencenin oluşturulmasının ve ebeveynin sağlık hizmetlerinden en iyi şekilde faydalanabilmesinin önemini vurgulamaktadır.
The exchange rate passthrough to domestic prices, new evidence from Colombia
Authors: Larrahondo Cristhian , Chávez Augusto , Giles Álvarez Laura , Andrian Leandro Gaston
Published: January 2025

This paper calculates the exchange rate pass through (ERPT) with time constant and time varying coefficients for Colombia between 2006 and 2023. It then estimates the ERPT during four specific depreciation events during the period of analysis: the 2008 financial crisis, the 2014-2016 fall in international fuel prices, the COVID-19 pandemic and the post-COVID recovery. A Bayesian Vector Autoregressive model with exogenous variables (BVARX) model with time constant and time varying coefficients is used for the exercise. The results for time constant coefficients show that a 1 percentage point (p.p.) increase in the depreciation of the exchange rate leads to an increase in imported, producer and consumer inflation of 0.42 p.p., 0.15p.p., and 0.01 p.p. respectively in the first month of the shock. Time varying coefficient results suggest that the nature and the size of the shock result in a heterogeneous ERPT and monetary policy response. Moreover, higher ERPT in imported inflation and producer inflation does not seem translate into higher ERPT in consumer inflation. Further studies could look at: First, the nature of the ERPT on different types of inflation and why this is heterogeneous in a time varying analysis. Second, how the combined effect of different factors in the Colombian economy led to different monetary policy responses in each of the four episodes under analysis.
Spillover effects of public capital stock: A case study for Ecuador
Authors: Zurita Roberto , Morales-Oñate Víctor
Published: January 2025

This research examines the spatial spillovers of public capital on gross value added across 216 cantons in continental Ecuador. The investigation is conducted within the framework of Spatial Econometrics, utilizing various model specifications and spatial weight matrices, complemented by a Cobb Douglas-type model that incorporates spatial dependence. The findings highlight a positive spatial impact of the public capital stock, with approximately 30% of the overall effect attributed to the indirect component. This underscores the importance of considering spatial structure when assessing the effects of capital on gross value added. Consequently, the study extends its exploration to derive column and row effects, aimed at identifying the most influential cantons within the neighborhoods established by the spatial structure.
Evaluation of saline treatments on bacteriological quality of Tiger Nut) Cyperus esculentus L.) for consumption post purchase
Authors: Arkoh Nana Ewusi , Amenya Priscilla Cecilia , , Aboagye George
Published: January 2025

Food-borne diseases are usually caused by ingestion of contaminated food. One of such foods susceptible to microbial contamination is Tiger nut (Cyperus esculentus L.). We evaluated the bacteriological quality of Tiger nuts under various consumer treatment conditions post purchase.Three tiger nut samples each from 7 vendors were obtained by convenient sampling in Ho, the capital of the Volta Region of Ghana. The samples were subjected to vigorous washes in 1%, 2% and 3% sterile saline with tap water as control. The resulting liquids were analysed for microbial load and species using specific media and standard microbial methods. Data obtained from the study were analysed by ANOVA, and significant differences among means were defined at p<0.05. The mean bacterial count for the fresh tiger nut in tap water ranged from 1.95×106 to 1.59×107 cfu/mL whilst that in tap water only (control), 1%, 2% and 3% saline solutions recorded a range of 7.08×105 to 1.18×107, 7.31×105 to 1.34×107, 4.0×104 to 1.13×107 and 1.11×105 to 9.62×106 cfu/mL respectively. The higher bacterial load from the tiger nut in the sterile tap water was above the acceptable reference limit of 105 cfu/mL by the National Administration for Food Drugs and Control (NAFDAC). The mean bacterial count of Escherichia coli and Staphylococcus aureus in all the 21 samples was 6.15 log10 and 6.18 log10 cfu/mL respectively, all of which exceeded the acceptable range from 102 to 103 cfu/mL by the International Commission on Microbiological Specifications for Foods (ICMSF).To improve the bacteriological quality of tiger nut, proper farming practices, handling and treatment regimens under hygienic conditions should be employed to reduce or eliminate the occurrence of contaminants to ensure the protection and safety of the consumer.
Predicting Attitudes towards Extramarital Relationship Based on Sexual Satisfaction and Performance in Individuals with Attention Deficit/Hyperactivity Disorder
Authors: Zaddah Bahareh , Babakhani Vahideh , Poyamanesh Jafar , Majd Mojtaba Amiri
Published: January 2025

Introduction: Extramarital relationships pose a challenge to family life and can negatively affect the mental health and well-being of family members. Various factors can contribute to the development of extramarital relationships. The present study aimed to predict attitudes towards extramarital relationships based on sexual satisfaction and performance in individuals with attention deficit/hyperactivity disorder (ADHD).
Methods: This study was correlational in nature. The study population included all married individuals seeking counseling and psychological services in Qazvin city in 2023, from which 216 individuals were selected by purposive sampling method. The World Health Organization ADHD self-report scale, Yeniceri and Kokdemir Extramarital Relationship Questionnaire, Larson Sexual Satisfaction Questionnaire, and the Farajina Sexual Performance Questionnaire were used for data collection. Data analysis was performed using SPSS-25 software and multiple regression analysis. All inferential analyses were conducted at a significance level of 0/05.
Rusults: The results indicated that sexual satisfaction (β = 0/19, t = 2/85) and sexual performance (β = 0/15, t = 2/26) could predict the variance of changes related to attitudes towards extramarital relationships.
Conclusion: Based on the obtained results, it is recommended to provide couples with this awareness during premarital counseling so that they can discuss sexual issues with marriage counselors and specialists and receive specialized counseling if needed to prevent the tendency towards extramarital relationships.
Gap Filling and consistency analysis in monthly rainfall series: case study in southeastern Mato Grosso
Authors: Todeschini Thaiana , Menezes Filho Frederico Carlos Martins de
Published: January 2025

The analysis of precipitation time series is crucial for understanding climate patterns and managing water resources. However, data gaps caused by missing information, technical issues, and data transmission failures compromise the accuracy of climate analyses and forecasts. This study aims to address these gaps and assess the consistency of monthly rainfall series in southeastern Mato Grosso, using the regional weighting method and the double-mass analysis. Data from five rainfall stations were selected: Vale Rico (01654005), Alto Araguaia (01753000), Fazenda Taquari (01853000), Alto Garças (01653004), and Itiquira (01754000), covering the period from 1984 to 2019, were extracted from the Hidroweb platform of the National Water and Sanitation Agency (ANA). The regional weighting method was effective in filling gaps. Consistency checks using the double-mass method revealed a linear trend in data, indicating no inconsistencies in the filled data. Notably, the Fazenda Taquari station (01853000), with had the mostgaps filled, showed a pronounced linear trend, demonstrating the effectiveness of the methodology. The findings suggest that the regional weighting method is suitable approach for gap filling in rainfall series, thereby enhancing the quality of data for hydrological studies in the region.