bluuebunny/crossref_metadata_2025 huggingface dataset:
The Salinity Survival Strategy of Chenopodium quinoa: Investigating Microbial Community Shifts and Nitrogen Cycling in Saline Soils
Authors: Zhao Xuli , Meng Tianzhu , Jin Shenghan , Ren Kaixing , Cai Zhe , Cai Bo , Li Saibao
Published: November 2023

Quinoa is extensively cultivated for its nutritional value, and its exceptional capacity to endure elevated salt levels presents a promising resolution to the agricultural quandaries posed by salinity stress. However, limited research has been dedicated to elucidating the correlation between alterations in the salinity soil microbial community and nitrogen transformations. To scrutinize the underlying mechanisms behind quinoa’s salt tolerance, we assessed the changes in microbial community structure and the abundance of nitrogen transformation genes across three distinct salinity thresholds (1 g·kg−1, 3 g·kg−1, and 6 g·kg−1) at two distinct time points (35 and 70 days). The results showed the positive effect of quinoa on the soil microbial community structure, including changes in key populations and its regulatory role in soil nitrogen cycling under salt stress. Choroflexi, Acidobacteriota, and Myxococcota were inhibited by increased salinity, while the relative abundance of Bacteroidota increased. Proteobacteria and Actinobacteria showed relatively stable abundances across time and salinity levels. Quinoa possesses the ability to synthesize or modify the composition of keystone species or promote the establishment of highly complex microbial networks (modularity index > 0.4) to cope with fluctuations in external salt stress environments. Furthermore, quinoa exhibited nitrogen (N) cycling by downregulating denitrification genes (nirS, nosZ), upregulating nitrification genes (Archaeal amoA (AOA), Bacterial amoA (AOB)), and stabilizing nitrogen fixation genes (nifH) to absorb nitrate–nitrogen (NO3−_N). This study paves the way for future research on regulating quinoa, promoting soil microbial communities, and nitrogen transformation in saline environments.
Effusanin B Inhibits Lung Cancer by Prompting Apoptosis and Inhibiting Angiogenesis
Authors: Hou Jiantong , Li Ying , Xing Honghong , Cao Ruyu , Jin Xiaomeng , Xu Jing , Guo Yuanqiang
Published: November 2023

Cancer is one of the deadliest human diseases, causing high rates of illness and death. Lung cancer has the highest mortality rate among all malignancies worldwide. Effusanin B, a diterpenoid derived from Isodon serra, showed therapeutic potential in treating non-small-cell lung cancer (NSCLC). Further research on the mechanism indicated that effusanin B inhibited the proliferation and migration of A549 cells both in vivo and in vitro. The in vitro activity assay demonstrated that effusanin B exhibited significant anticancer activity. Effusanin B induced apoptosis, promoted cell cycle arrest, increased the production of reactive oxygen species (ROS), and altered the mitochondrial membrane potential (MMP). Based on mechanistic studies, effusanin B was found to inhibit the proliferation and migration of A549 cells by affecting the signal transducer and activator of transcription 3 (STAT3) and focal adhesion kinase (FAK) pathways. Moreover, effusanin B inhibited tumor growth and spread in a zebrafish xenograft model and demonstrated anti-angiogenic effects in a transgenic zebrafish model.
Illicium verum L. (Star Anise) Essential Oil: GC/MS Profile, Molecular Docking Study, In Silico ADME Profiling, Quorum Sensing, and Biofilm-Inhibiting Effect on Foodborne Bacteria
Authors: Noumi Emira , Ahmad Iqrar , Adnan Mohd , Patel Harun , Merghni Abderrahmen , Haddaji Najla , Bouali Nouha , Alabbosh Khulood Fahad , Kadri Adel , Caputo Lucia , Polito Flavio , Snoussi Mejdi , Feo Vincenzo De
Published: November 2023

Illicium verum, or star anise, has many uses ranging from culinary to religious. It has been used in the food industry since ancient times. The main purpose of this study was to determine the chemical composition, antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil (EO) obtained via hydro-distillation of the aerial parts of Illicium verum. Twenty-four components were identified representing 92.55% of the analyzed essential oil. (E)-anethole (83.68%), limonene (3.19%), and α-pinene (0.71%) were the main constituents of I. verum EO. The results show that the obtained EO was effective against eight bacterial strains to different degrees. Concerning the antibiofilm activity, trans-anethole was more effective against biofilm formation than the essential oil when tested using sub-inhibitory concentrations. The results of anti-swarming activity tested against P. aeruginosa PAO1 revealed that I. verum EO possesses more potent inhibitory effects on the swarming behavior of PAO1 when compared to trans-anethole, with the percentage reaching 38% at a concentration of 100 µg/mL. The ADME profiling of the identified phytocompounds confirmed their important pharmacokinetic and drug-likeness properties. The in silico study using a molecular docking approach revealed a high binding score between the identified compounds with known target enzymes involved in antibacterial and anti-quorum sensing (QS) activities. Overall, the obtained results suggest I. verum EO to be a potentially good antimicrobial agent to prevent food contamination with foodborne pathogenic bacteria.
Options in the (Semi-)Periphery: A Review of Multilingual Scholars’ Choices of Topics, Methodologies, and Theories in Research and Publishing
Authors: Xu Xiatinghan
Published: November 2023

In most global contexts, academic publishing plays an essential part of scholars’ professional lives. For multilingual scholars, who may use multiple languages and publish for different communities, publishing can entail making a range of important choices. To date, while there has been a substantial amount of research on multilingual scholars’ choices of language and genre, little has focused on their choices of topics, methodologies, and theories, which are also important aspects of their research and publishing practices. In this review article, I explore specifically what the extant research has found about why multilingual scholars make particular choices of topics, methodologies, and theories outside of Anglophone contexts. Reviewing research published between 2004 and 2023, I found that overall, scholars’ choices in such aspects are motivated by their desire for professional success and their aims of making academic and social contributions. Also, their choices can be further complicated by various sociopolitical factors. I argue that the current strand of research mainly focuses on the neoliberal contexts of publishing and the effects of Anglophone academia on global knowledge production, whereas the practices of multilingual scholars outside the Anglosphere can be also affected by many other factors that have received less attention.
Slope-Scale Evolution Categorization of Deep-Seated Slope Deformation Phenomena with Sentinel-1 Data
Authors: Cardone Davide , Cignetti Martina , Notti Davide , Godone Danilo , Giordan Daniele , Calò Fabiana , Verde Simona , Reale Diego , Sansosti Eugenio , Fornaro Gianfranco
Published: November 2023

Deep-seated gravitational slope deformations (DsGSDs) are slope-scale phenomena which are widespread in mountainous regions. Despite interacting with human infrastructures and settlements, only a few cases are monitored with ground-based systems. Remote sensing technologies have recently become a consolidated instrument for monitoring and studying such widespread and slow processes. This paper proposes a three-step novel methodology to analyze the morpho-structural domain of DsGSDs by exploiting the advanced Differential Synthetic Aperture Radar Interferometry (A-DInSAR) technique through (i) the analysis of A-DInSAR measurement point density and distribution defining a coverage threshold; (ii) the assessment of the actual ground deformation with respect to the orientation of phenomena based on slope, aspect, and C-index; and (iii) ground deformation mapping with previously ranked velocity interpolation. The methodology was tested on two differently oriented phenomena: the mainly north–south-oriented Croix de Fana and the mainly east–west-oriented Valtournenche DsGSD, located in the Aosta Valley Region, northern Italy. The results show a variation in the kinematic behavior between the morpho-structural domains, while also considering any other superimposed surficial deformations. This work provides the lines for the implementation of a rapid and low-cost tool based on the use of A-DInSAR measurements which are suitable for assessing the impact of any type of DsGSD on the anthropic facilities and infrastructures in mountainous areas.
Research on a Wire Rope Breakage Detection Device for High-Speed Operation Based on the Multistage Excitation Principle
Authors: Zhou Zhou , Zhang Xiuheng , Deng Ran , Han Lu , Zhou Meng , Ma Zhuangzhuang , Chang Xiangdong , Peng Yuxing
Published: November 2023

Wire rope breakage, as damage easily produced during the service period of wire rope, is an important factor affecting the safe operation of elevators. Especially in the high-speed elevator operation process, the problem of magnetization unsaturation caused by speed effects can easily lead to deformation of the magnetic flux leakage detection signal, thereby affecting the accuracy and reliability of wire breakage quantitative detection. Therefore, this article focuses on the problem that existing wire rope detection methods cannot perform non-destructive testing on high-speed elevator wire ropes and conducts design and experimental research on a high-speed running wire rope breakage detection device based on the principle of multi-stage excitation. The main research content includes simulation research on the multistage excitation, structural design, and simulation optimization of open–close copper sheet magnetizers and the building of a detection device for wire rope breakage detection experimental research. The simulation and experimental results show that the multistage magnetization method can effectively solve the problem of magnetization unsaturation caused by the velocity effect. The multistage excitation device has a good wire breakage recognition effect for speeds less than or equal to 3 m/s. It can detect magnetic leakage signals with a minimum of four broken wires and has good detection accuracy. It is a new and effective wire breakage detection device for high-speed elevator wire rope, providing important technical support for the safe and reliable operation of high-speed elevators.
A Communication-Efficient, Privacy-Preserving Federated Learning Algorithm Based on Two-Stage Gradient Pruning and Differentiated Differential Privacy
Authors: Li Yong , Du Wei , Han Liquan , Zhang Zhenjian , Liu Tongtong
Published: November 2023

There are several unsolved problems in federated learning, such as the security concerns and communication costs associated with it. Differential privacy (DP) offers effective privacy protection by introducing noise to parameters based on rigorous privacy definitions. However, excessive noise addition can potentially compromise the accuracy of the model. Another challenge in federated learning is the issue of high communication costs. Training large-scale federated models can be slow and expensive in terms of communication resources. To address this, various model pruning algorithms have been proposed. To address these challenges, this paper introduces a communication-efficient, privacy-preserving FL algorithm based on two-stage gradient pruning and differentiated differential privacy, named IsmDP-FL. The algorithm leverages a two-stage approach, incorporating gradient pruning and differentiated differential privacy. In the first stage, the trained model is subject to gradient pruning, followed by the addition of differential privacy to the important parameters selected after pruning. Non-important parameters are pruned by a certain ratio, and differentiated differential privacy is applied to the remaining parameters in each network layer. In the second stage, gradient pruning is performed during the upload to the server for aggregation, and the final result is returned to the client to complete the federated learning process. Extensive experiments demonstrate that the proposed method ensures a high communication efficiency, maintains the model privacy, and reduces the unnecessary use of the privacy budget.
Aerosol Emissions from Heated Tobacco Products: A Review Focusing on Carbonyls, Analytical Methods, and Experimental Quality
Authors: Sussman Roberto A. , Sipala Federica , Emma Rosalia , Ronsisvalle Simone
Published: November 2023

We provide an extensive review of 17 independent and industry-funded studies targeting carbonyls in aerosol emissions of Heated Tobacco Products (HTPs), focusing on quality criteria based on the reproducibility of experiments, appropriate analytic methods, and puffing regimes. Most revised studies complied with these requirements, but some were unreproducible, while others failed to consider analytical variables that may have affected the results and/or produced unrealistic comparisons. We also provide a review of the literature on the physicochemical properties of heated tobacco and HTP aerosols, as well as the evaluation of HTPs by regulatory agencies, addressing various critiques of their relative safety profile. The outcomes from the revised studies and regulatory evaluations tend to agree with and converge to a general consensus that HTP aerosols expose users to significantly lower levels of toxicity than tobacco smoke.
Short-Term Ambient Air Pollution and Urticaria in Guangzhou, China: Estimating the Association and Population Attributable Fraction
Authors: Wang Huanli , Matusik Morgan , Wunderlich Robert , Hanson Sarah E. , Babich Kelly , Samad Lilianne , Qian Aaron M. , McMillin Stephen Edward , Ye Xingdong , Zhang Sanquan , Liu Yumei , Chen Xiaoyin , Li Zhenjie , Lin Hualiang , Zhu Huilan , Wang Xiaojie
Published: November 2023

Limited evidence is available regarding the association between acute exposure to ambient air pollutants and the risk of urticaria, even though the skin is an organ with direct contact with the external environment. This study utilized generalized additive models to investigate the association between particulate matter with an aerodynamic diameter smaller than 10 μm (PM10) and 2.5 μm (PM2.5), nitrogen dioxide (NO2) and sulfur dioxide (SO2), and daily outpatient visits for urticaria in Guangzhou, China from 2013 to 2017. We also estimated the attributable fraction of urticaria outpatient visits due to air pollution. A total of 216,648 outpatient visits due to urticaria occurred during the study period. All air pollutants were significantly associated with an increased excess risk of urticaria. Each 10 μg/m3 increase in PM2.5, PM10, NO2, and SO2 was associated with an increase of 1.23% (95% CI: 0.42%, 2.06%), 0.88% (95% CI: 0.28%, 1.49%), 3.09% (95% CI: 2.16%, 4.03%), and 2.82% (95% CI: 0.93%, 4.74%) in hospital visits for urticaria at lag05, respectively. It was estimated that 3.77% (95% CI: 1.26%, 6.38%), 1.91% (95% CI: 0.60%, 3.26%), 6.36% (95% CI: 4.38%, 8.41%), and 0.08% (95% CI: 0.03%, 0.14%) of urticaria outpatient visits were attributable to PM2.5, PM10, NO2, and SO2 using the World Health Organization’s air quality guideline as the reference. Relatively stronger associations were observed during the cold season. This study indicates that short-term air pollution may play a significant role in outpatient visits for urticaria, and that such relationships could be modified by season.
Some Unmodified Household Adsorbents for the Adsorption of Benzalkonium Chloride—A Kinetic and Thermodynamic Case Study for Commercially Available Paper
Authors: Bitay Enikő , Csavdari Alexandra
Published: November 2023

The extensive use of biocide surfactant benzalkonium chloride (BAC) during the SARS-CoV-2 pandemic has led to the buildup of this hazardous chemical in waste, surface and groundwater. e The study aims to elucidate whether various low-cost household materials are suitable, in their unmodified and untreated form, to effectively adsorb BAC from its aqueous solutions.. Additionally, if a proper adsorbent is identified, a description of the kinetics and thermodynamics of the process is also targeted. From among the five tested materials, a commercially available white household paper towel was chosen to best satisfy the criteria of low price, large availability, and standardization degree, as well as high adsorption capacity within a fairly short time window needed until equilibrium. Batch experiments were carried out with a commercial mixture of BAC-12 and BAC-14 within a temperature range of 18-45 degrees Celsius, and a 25-100 mg/g BAC/adsorbent initial mass ratio range, respectively. The overall process follows a pseudo-second-order kinetic law, with an apparent activation energy of 73.35 KJ/mole. Both the Langmuir and the Redlich–Peterson isotherms describe the equilibrium data at 298 K well, with a Gibbs free energy of −20.64 KJ/mole. These findings are in agreement with previous reports and suggest a hybrid but chemisorption-dominated process.
Knowledge, Attitudes, and Willingness of Healthcare Workers in Iraq’s Kurdistan Region to Vaccinate against Human Monkeypox: A Nationwide Cross-Sectional Study
Authors: Ahmed Sirwan Khalid , Abdulqadir Salar Omer , Omar Rukhsar Muhammad , Hussein Safin , Qurbani Karzan , Mohamed Mona Gamal , Abubaker Blbas Hazhar Talaat , Fahrni Mathumalar Loganathan , Lazzarino Antonio Ivan
Published: November 2023

Although human monkeypox infections had not been recorded in the Kurdistan region of Iraq as of August 2023, the rapid growth of cases worldwide and the detection of monkeypox in neighboring Middle Eastern nations call for careful planning and timely response measures. Educating and empowering frontline healthcare workers (HCWs) so that they can act to curb the spread of monkeypox infections are core elements of primary prevention and protecting public health. Therefore, this study aimed to assess HCWs’ knowledge and attitudes about monkeypox and their willingness to vaccinate against monkeypox. By employing a convenience sampling method, an online survey was disseminated via Google Forms between 1 November 2022 and 15 January 2023. The researchers utilized regression analyses to ascertain the factors associated with the three parameters: knowledge, attitude, and the willingness to vaccinate. A total of 637 HCWs were included in the analysis (ages ranged between 21 and 51 years). The mean overall scores were 8.18 of a max score of 16 (SD 3.37), 3.4 of 5 (SD 1.37), and 2.41 of 5 (SD 1.25) for knowledge, attitude, and willingness to vaccinate, respectively. A multivariate logistic regression analysis demonstrated that HCWs who had heard about monkeypox before 2022 rather than later had a higher level of knowledge (AOR: 4.85; 95% CI: 2.81–8.36; p < 0.001). In addition, those who had newly joined the workforce or had less than 1 year experience in practice had more positive attitudes about curbing monkeypox (AOR: 0.35; 95% CI: 0.20–0.59; p < 0.01) than those who practiced for longer. No significant predictors of willingness to vaccinate against monkeypox were identified. The research revealed that HCWs exhibited a relatively low level of monkeypox knowledge. They also had poor attitudes towards monkeypox vaccination and were therefore reluctant to receive the vaccines. Imparting knowledge about the infectious disease can cultivate better awareness and attitudes among HCWs as to their roles in mitigating the spread of an epidemic in the foreseeable future.
Patients’ experience with German primary care practices during Covid-19: an interview study
Authors: Otto Daniel , van der Wardt Veronika
Published: November 2023

Background

Patient access to and communication with German primary care practices (PCPs) changed due to Covid-19. Patients had to comply with Covid-19 regulations, which included closed waiting rooms and appointment-based consultations. It is unclear how patients experienced these changes and how the pandemic impacted their primary care attendance.

Aim

The aim of the study was to explore how patients, who frequently attended PCPs before the pandemic, perceived primary care during the initial phase of Covid-19 in Germany.

Design & setting

Between January and June 2021, we completed 17 semi-structured interviews. Participants included primary care patients from two regions in Germany who frequently attended their physician before the start of the pandemic.

Method

Data were analysed using content analysis.

Results

Four interconnected themes emerged in the analysis: ‘fear of COVID-19 infection’, ‘practice organisation’, ‘information about COVID-19’, and ‘telemedicine’. Participants were unconcerned about being infected in their practice and mostly agreed with COVID-19 regulations, although waiting outside for their appointment was uncomfortable for some. Participants consulted their primary care physician in relation to different vaccines but felt they were sufficiently informed regarding general information about COVID-19. Views on telemedicine, which was mostly understood as contact via telephone or video call, differed widely, with some participants being very accepting and interested, while others dismissed telemedicine categorically.

Conclusion

Participants regarded the new COVID-19 regulations as sensible. Telemedicine using telephone or video call consultations should be further explored under the assumption that this would be acceptable for some but not all patients.
PERANCANGAN SISTEM APLIKASI PEMBAYARAN MENGGUNAKAN QR-CODE DI KANTIN UNIVERSITAS DINAMIKA BANGSA
Authors: M. Ade. Maulana  , Ibrahim Mikhail , Hendryzal  , Dodo Zaenal Abidin
Published: November 2023

Sistem Pembayaran menjadi sangat penting di masa sekarang untuk melakukan transaksi untuk meningkatkan efisiensi dan keefektivan. Proses pembayaran di kantin Universitas Dinamika Bangsa Kota Baru masih dilakukan secara konvensional, hal tersebut tidak efisien baik dalam waktu dan tempat karena dapat memakan waktu ketika penjual harus memberikan uang kembalian dan dapat menimbulkan antrian. Dari permasalahan yang ada diperlukan sistem yang dapat memudahkan penjual dan pembeli dalam melakukan transaksi. Adapun metode pengembangan sistem yang digunakan adalah waterfall, alat bantu pemodelan program yaitu UML diantaranya use case diagram, activity diagram, dan class diagram. Serta sistem dirancang dengan bahasa pemrograman Dart dan database FireBase. Penelitian ini menghasilkan sebuah aplikasi pembayaran menggunakan Qr-Code yang dapat membantu pihak kantin dalam melakukan transaksi si kantin Universitas Dinamika Bangsa Kota Baru.
Perancangan Sistem Informasi Persediaan Pada Reklame Afia Berbasis Web
Authors: Muhammad Afif Dzaky Khairullah  , Rohaini Eni , Yovi Pratama
Published: November 2023

Pengolahan data dan pembuatan laporan masih dilakukan dengan bantuan buku sehingga terkadang dalam pencatatan dapat terjadi kesalahan yang menyebabkan ketidak akuratan data. Tujuan penelitian ini adalah untuk menganalisa sistem yang sedang berjalan agar dapat mengatasi masalah-masalah yang dihadapi pada Reklame Afia dengan cara merancang Sistem Informasi Persediaan Pada Reklame Afia Berbasis Web. Metode pengembangan sistem menggunakan model air terjun (waterfall), implementasi penelitian ini menggunakan Bahasa Pemrograman PHP dan Framework Laravel versi 6 serta DBMS MySQL, hingga menghasilkan aplikasi yang dapat memberikan kemudahan bagi pemilik toko dalam melakukan persediaan barang masuk dan barang keluar pada Reklame Afia. Toko Reklame Afia dalam melakukan mengolah data customer, supplier, Persediaan barang masuk dan barang keluar agar laporan yang dibutuhkan lebih baik dan tersistem.
Perancangan Sistem Informasi Inventory Barang Berbasis Web pada Toko Laris Furniture Jambi
Authors: Calista Stephanie , Husaein Ahmad , Gunardi
Published: November 2023

Toko Laris Furniture Jambi adalah salah satu toko furniture yang ada di Kota Jambi yang berlokasi di Jl. Pangeran Hidayat, RT. 23, Kel. Paal Lima, Kec. Kota Baru, Kota Jambi. Saat ini, semua proses transaksi persediaan stok dan penjualan barang pada Toko Laris Furniture Jambi ini masih bersifat konvensional atau manual, yaitu masih menggunakan nota manual dan buku tulis sebagai media dalam mencatat jumlah persediaan stok dan penjualan barang. Oleh karena itu, penelitian ini bertujuan untuk memberikan solusi pemecahan masalah terbaik atas masalah yang dihadapi dengan merancang sistem informasi inventory barang dengan menggunakan bahasa pemograman PHP dan DBMS MySQL. Penelitian ini menerapkan model perancangan sistem waterfall (air terjun) dan menggunakan metode UML (Unified Modelling Language) dengan membuat pemodelan sistem seperti Use Case Diagram, Activity Diagram, Class Diagram, dan Flowchart Diagram. Dengan adanya sistem informasi ini diharapkan dapat memberikan kemudahan bagi pengguna sistem baik admin, pemilik, kasir dan gudang untuk mengurangi kesalahan dalam pengolahan data inventory barang serta membantu dalam rekapitulasi dan pembuatan laporan yang tersimpan secara otomatis, lengkap, terkomputerisasi dan terintegrasi dengan baik.
PELATIHAN APLIKASI PLATFORM DIGITAL E-COMMERCE SEBAGAI MEDIA PEMASARAN DIGITAL PADA UMKM UP2K KELURAHAN PAALMERAH
Authors: Utami Febby Nanda , Yossinomita  , Mira Gustiana Pangestu  , Dwi Angraini
Published: November 2023

Situasi era digital telah memasuki era industri 4.0 dimana perkembangannya saat ini tidak hanya berdampak pada perkembangan teknologi dan administrasi saja tetapi juga telah berdampak pada sektor ekonomi. Manfaat dari perkembangan teknologi dirasakan sangat besar menjadi titik balik perubahan gaya hidup masyarakat.Situasi ini dimanfaatkan oleh pemilik usaha, khususnya pemilik UMKM, menjadikan media sosial sebagai salah satu media yang digunakan untuk mengembangkan bisnis dan jaringan bisnisnya (Tabrani et al., 2022).Bagi pelaku bisnis modern, jaringan teknologi komunikasi dan informasi menjadi alternatif dalam mengelola bisnis, baik dalam pengelolaan manajerial, maupun dalam melakukan interaksi antar internal perusahaan (Putra Zai et al., 2021).Pemasaran sendiri dilakukan menggunakan media-media sosial dan yang lebih terbaru berupa e-commerce sebagai media digital baru dalam pemasaran. Penggunaan media digital berupa e-commerce membuat promosi produk dapat dilakukan tanpa batasan ruang dan waktu (ES et al., 2021).E-  commercemenjadi prospek yang baik bagi para pelaku usaha karena telah  memangkas biaya operasional. Melalui e-commerce penjual tidak diharuskan memiliki outlet fisik untuk berjualan (Ujiandari & Saputro, 2018).
Pemanfaatan Media Sosial Berbasis AR Untuk Mengidentifikasi Dalam Pemilihan Bingkai Kacamata Pada Toko Kacamata Idri
Authors: Valensia Vally , Kurniabudi Kurniabudi
Published: November 2023

At the Toko Kacamata Idri, currently users who want to buy glasses can try the product directly and use it physically at the shop or glasses users who are far outside the city can order via Instagram or Whatsapp. However, ordering online makes glasses users unable to see and try the shape of the glasses ordered directly due to the distance constraint. This study aims to develop virtual eyeglass frames based on Augmented Reality with the Face Tracker Decoration method and the Augmented Reality Random method which are able to provide views and recommendations for glasses based on face shape by adapting the morphology of facial indexes as determining the type of face at the Toko Kacamata Idri. This design is done using the Meta Spark Studio application. The design results are in the form of effects that can be used in the Instagram application. There are three designs in this study, effect designs to identify face types, effects designs to display glasses recommendations and designs to display eyewear products.
TNF-α from the Proximal Nephron Exacerbates Aristolochic Acid Nephropathy
Authors: Wen Yi , Lu Xiaohan , Privratsky Jamie R. , Ren Jiafa , Ali Saba , Yang Bo , Rudemiller Nathan P. , Zhang Jiandong , Nedospasov Sergei A. , Crowley Steven D.
Published: November 2023

Key Points

Proximal tubular TNF aggravates kidney injury and fibrogenesis in aristolochic acid nephropathy.

Tubular TNF disrupts the cell cycle in injured tubular epithelial cells.

TNF-mediated toxic renal injury is independent of systemic immune responses.

Background

Aristolochic acid nephropathy (AAN) presents with tubular epithelial cell (TEC) damage and tubulointerstitial inflammation. Although TNF-α regulates cell apoptosis and inflammatory responses, the effects of tubular TNF in the progression of AAN require elucidation.

Methods

Floxed TNF mice on the 129/SvEv background were crossed with PEPCK-Cre mice to generate PEPCK-Cre

+

TNF

flox/flox
(TNF PTKO) mice or bred with Ksp-Cre mice to generate KSP-Cre

+

TNF

flox/flox
(TNF DNKO) mice. TNF PTKO, TNF DNKO, and wild-type controls (Cre negative littermates) were subjected to acute and chronic AAN.

Results

Deletion of TNF in the proximal but not distal nephron attenuated kidney injury, renal inflammation, and tubulointerstitial fibrosis after acute or chronic aristolochic acid (AA) exposure. The TNF PTKO mice did not have altered numbers of infiltrating myeloid cells in AAN kidneys. Nevertheless, kidneys from AA-treated TNF PTKO mice had reduced levels of proteins involved in regulated cell death, higher proportions of TECs in the G0/G1 phase, and reduced TEC proportions in the G2/M phase. Pifithrin-α, which restores the cell cycle, abrogated differences between the wild-type and PTKO cohorts in G2/M phase arrest of TECs and kidney fibrosis after AA exposure.

Conclusions

TNF from the proximal but not the distal nephron propagates kidney injury and fibrogenesis in AAN in part by inducing G2/M cell cycle arrest of TECs.
Introduction: About This Issue
Authors: Allen Natalie
Published: November 2023

This special issue of Asylum, guest edited by The Urban Advisory, is an opportunity to broaden the remit of the publication to be a curated collection of peer-reviewed and practitioner-led articles designed to challenge our collective thinking about a key urban topic. Specifically, the editors were challenged to bring together ideas commonly restricted to academic journals and share them more widely into the professional sphere. The theme of this issue is Rethinking Our Future Neighbourhoods, a concept at the essence of what the team at The Urban Advisory strives to do. As a result, this issue is focused on evolving the discourse in Aotearoa about the design and delivery of our future neighbourhoods. We have drawn together articles that explore ways to address our social, cultural and environmental challenges, opportunities for decolonisation, what embracing citizen-centric approaches to designing our neighbourhoods might look like, and how the built-environment professions might work together in new ways to deliver these wellbeing outcomes. The issue includes new, young voices, and some less-than-conventional ideas. The combination of peer-reviewed and practitioner articles asks the reader to imagine what a neighbourhood might be, and challenge their own preconceptions.
Imagining a Narrative Form for Place
Authors: Billing Charlotte , Allen Liz
Published: November 2023

Applying long-term thinking to placemaking is challenging when practitioners work within short timeframes to deliver a project – usually from the length of a funding window to that of an on-the-ground build. In order for placemaking activities to uphold the future vision for a place, new frameworks can be applied to widen our lens. Narrative structure is the framework of storytelling, in which the beginning, middle and end are distinct phases where the action of each propels the story and its characters forward, creating plot. The success of a story relies on sustaining the integrity of how the action of each phase links to what happens next. Telling the story of our future neighbourhoods by mapping out their history, their present, and their possibility will help to shape more people-centric places in vital areas of our towns and cities. This article demonstrates how to use narrative structure as a lens to deliver our future neighbourhoods in a way that shifts our time scale for meaningful placemaking. It articulates each phase of a place’s lifespan: the place’s past, present and future, in order to develop a context for placemaking activities. Within each phase, practical guidance is given on what to consider, and how to apply this thinking to places and placemaking.
Designing Neighbourhoods to Facilitate Intercultural Encounters: Negotiating Between Self, Society and Place
Authors: Soni Niyati
Published: November 2023

Globalisation, and the consequent migratory processes, have radically transformed many countries across the world. A greater number of people with diverse backgrounds have been travelling to more places for numerous reasons. Consequently, immigrants have become an intrinsic part of most societies across the globe. When an individual travels from one place to another, they carry unique cultural information about specific areas. As such, immigrants inadvertently influence the spatial environment they interact with. Consequently, the built context of destination areas can be interpreted as the physical manifestation of accumulated information over time. Thus, immigrants effectively serve as catalysts for increasing levels of cultural flow between the place they have come from and the place they choose to resettle.
Walking Backwards into the Future in Te Pokapū Tāone, Auckland’s City Centre
Authors: Nicholls Liz
Published: November 2023

Te pokapū tāone o Tāmaki, Auckland’s city centre, is the belly of Tāmaki Makaurau, Aotearoa New Zealand’s fastest-growing residential neighbourhood and a significant contributor to the region and to the country. Globally, cities have been significantly impacted by Covid-19 and this has led to questions of the viability of city centres and central business districts and their future role. If we look to the patterns of this wāhi, or place, Tāmaki Makaurau Auckland’s city centre has been founded on, and will continue to be, a neighbourhood, drawing together diverse functions such as being a place for people to live, for trade, for education and for entertainment. However, we know that the city-centre experience will change, and we need to look far into the future to help the city centre become a resilient place that supports human and environmental wellbeing. This paper outlines the importance of future thinking in planning, development and programming, and behaviour change to support the city centre to be a healthy neighbourhood and to become a resilient place for people.
The Fires of Ambition: Te Awa Tupua 2040
Authors: Ta'ala Ahlia-Mei
Published: November 2023

Upon introduction, Māori will often, ask “Ko wai koe?”, or at the beginning of a pepeha, Māori might say, “Ko wai au?” The concept of ‘ko wai au’ is both a question and a statement in one. In one sense ‘ko wai au’ is asking “Who am I?”, in another, it is also stating who I am by saying “I am water.” Ko wai au – wai is me. So the question really asks, which waters are you from? Which are the waters that feed you, that nourish you, that have sustained you and given you life? Ancestrally, tūrangawaewae (a place to stand and belong) was founded within the centralised societal frameworks of pre-colonial Aotearoa, based on whānau/hapū (family/sub-tribe), and it was formed in relation to the geographical features of a place: to the mountains, the rivers and the lakes that define a place. For Māori, water is central to who we are; and our waters have become inaccessible to us. For many of us, growing up Māori in New Zealand can be an extremely confusing time, particularly when living in urban centres, which applies to 84 percent of Māori, according to Te Ara – The Encyclopedia of New Zealand. Contemporary urban neighbourhoods in Aotearoa do not reflect our whakapapa, histories and connections to whenua, disconnecting us from tūrangawaewae, providing an unstable environment to build our identity and culture on. We know we’re from here, but we don’t really know how, and what that means anymore. Not in the sense that our ancestors knew in detail how they were connected to every little part of the ecosystem that they were in. So if we don’t really know who we are, and where we come from, how do we then know where to go? How do we build an abundant pathway forward, without a clear understanding of the cultural, historical, ancestral, geographical and spiritual foundations that we live on? How do we connect to place? How do we build a strong sense of identity, when the awa (rivers) continue to be siphoned for money and power, the maunga (mountains) are quarried or built over, and the moana (ocean) is dominated by our built environment and polluted with our waste? And how do we connect to place, especially when we feel disconnected from our hau kāinga (true home)?
Resilient Hub
Authors: Hickling Ben
Published: November 2023

The proposal describes a community hub; a site located within the suburban and urban built environment, made up of an arrangement of community-run buildings and facilities. Modern sustainable technologies and building typologies will be promoted and community interaction encouraged. Multiple functions will work in unison, with all members of the surrounding community interfacing with it. Through participation, collaboration and creative contribution, the Resilient Hub will demonstrate in a tangible, real-time way the connection between energy, water, food production, food preparation, food consumption, compost and energy use. The knowledge and practices gained will proliferate in community members’ daily practices and help to accelerate the uptake of sustainable technology, building construction and use. Involving the community at the design stage will further integrate the relevance of these sustainable methods. All these aspects combine to challenge us to think in a more integrated way about our future neighbourhoods and how all aspects of them are part of an interconnected system.
Developing Urban Furniture by Unitec Students for an Emerging Urban Fabric in Auranga, New Zealand: The Socio-Ecological Dynamics of Creative Sustainable Prototyping Production During the Covid Crisis
Authors: Shamout Sameh , Patel Yusef , Premier Alessandro
Published: November 2023

As the number of suburban communities in Tāmaki Makaurau Auckland grows, it’s essential to consider the social component when planning and developing these communities in order to improve social resilience and reduce social and economic disparities between residents in these areas and those in the city centre. Since the Covid-19 crisis forced people to stay in their neighbourhoods during lockdowns, social urban spaces have become one of the most important urban necessities for achieving urban resilience and sustainable development goals. Given the role that urban furniture plays in making urban social spaces more attractive and liveable, this paper discusses two student-built urban furniture projects, a multi-functional bike pod and a popup performance container. Students from Unitec School of Architecture designed and built the two projects for MADE Group’s Auranga housing development in Karaka, South Auckland, as an example of enhancing social resilience in a suburban community in Tāmaki Makaurau Auckland.
FAKTOR YANG MEMPENGARUHI PERILAKU GEN Z TERHADAP KEPUTUSAN MEMBELI DALAM PENGGUNAAN APLIKASI TIK TOK
Authors: Rosita Rahmi
Published: November 2023

A phenomenon that has emerged recently is the shift in consumer buying interest from e-commerce based platforms to purchasing via tok tok as a digital platform. This research aims to describe 1. The influence of advertising on interest in buying 2. To determine the influence of the Tik Tok application on interest in buying. 3. To find out the influence of advertising and the Tik Tok application on interest in buying This research uses a quantitative type of research. The sample in this study was 60 residents of the city of Bekasi using the specified purposive sampling technique. The research instrument uses data analysis techniques and quasi-questionnaire questionnaires with instrument testing using multiple linear regression analysis methods with analytical requirements tests, hypothesis testing. The research results show that: 1, Advertising Advertising has a positive and significant effect on interest in buying, with a t-table value of 1.295 and a significance level of 0.000<0.05. (2). The Tik Tok application influences interest in buying with a t-table value of 1.295 with a significance level of 0.000 < 0.05. (3). Advertisements and the Tik Tol application together have a positive and significant effect on interest in buying with a calculated F value of 47.386 > F Table 2.39 and a significance level of 0.000 < 0.05. The magnitude of the influence of advertising and the Tik Tok application on interest in buying is 61.2%.

Keywords : Tik tok application, advertising influence, purchase interest.
Development and Characterization of Novel FAP-Targeted Theranostic Pairs: A Bench-to-Bedside Study
Authors: Huang Wei , Pang Yizhen , Liu Qiufang , Liang Chenyi , An Shuxian , Wu Qianyun , Zhang You , Huang Gang , Chen Haojun , Liu Jianjun , Wei Weijun
Published: November 2023

Fibroblast activation protein (FAP) is among the most popular targets in nuclear medicine imaging and cancer theranostics. Several small-molecule moieties (FAPI-04, FAPI-46, etc.) are used for developing FAP-targeted theranostic agents. Nonetheless, the circulation time of FAP inhibitors is relatively short, resulting in rapid clearance via kidneys, low tumor uptake, and associated unsatisfactory treatment efficacy. To address the existing drawbacks, we engineered 3 peptides named FD1, FD2, and FD3 with different circulation times through solid-phase peptide synthesis. All the 3 reported peptides bind to human and murine FAP with single-digit nanomolar affinity measured by surface plasmon resonance. The diagnostic and therapeutic potential of the agents labeled with
68
Ga and
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Lu was assessed in several tumor models exhibiting different levels of FAP expression. While radiolabeled FD1 was rapidly excreted from kidneys, radiolabeled FD2/FD3 have significantly prolonged circulation, increased tumor uptake, and decreased kidney accumulation. Our findings indicated that [
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Ga]Ga-DOTA-FD1 positron emission tomography (PET) effectively detected FAP dynamics, whereas [
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Lu]Lu-DOTA-FD2 and [
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Lu]Lu-DOTA-FD3 exhibited remarkable therapeutic efficacy in FAP-overexpressing tumor models, including pancreatic cancer cell models characterized by abundant stroma. Moreover, a pilot translational investigation demonstrated that [
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Ga]Ga-DOTA-FD1 had the capability to identify both primary and metastatic tumors with precision and distinction. In summary, we developed [
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Ga]Ga-DOTA-FD1 for same-day PET imaging of FAP dynamics and [
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Lu]Lu-DOTA-FD2 and [
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Lu]Lu-DOTA-FD3 for effective radioligand therapy of FAP-overexpressing tumors.
Optimasi Proses Pembuatan Asap Cair dari Tempurung Kelapa Melalui Response Surface Methodology (RSM)
Authors: Kholisoh Siti Diyar , Achmad Zubaidi , Hadi Faizah
Published: November 2023

Response Surface Methodology (RSM) is a collection of mathematical and statistical techniques that are useful for analyzing complex processes that are influenced by several variables. This research aimed to apply RSM in optimizing the process of making liquid smoke from coconut shell pyrolysis. Optimum process conditions were reviewed based on the content of several functional compounds in liquid smoke including carbonyl content, phenol content, and acid content. The process variables comprised pyrolysis temperature (within the temperature range of 350 oC as low level (-1) and 450 oC as high level (+1)), pyrolysis time (within the range of 45 minutes as low level (-1) and 75 minutes as high level (+1)), and the water content in the coconut shell (within the range of 10% water content as low level (-1) and 20% as high level (+1)). This study results showed that the best carbonyl content in liquid smoke was 3.58% at temperature of 395 oC, pyrolysis time of 60 minutes, and water content of 16%. The optimum phenol content of 5.55% was achieved with a combination of pyrolysis time of 65 minutes and water content of 15.5%. Based on the acid content, an optimum value of 19.55% was obtained at a combination of pyrolysis time of 62 minutes and water content of 15.5%. The hypothesis H0 could be accepted statistically for the carbonyl content.
COMMENTS TO COMMENTS (Regarding the preparation of the Complete Works of A.N. Ostrovski in 18 volumes)
Authors: Tikhomirov Vladimir V.
Published: November 2023

The author of this article shows us how the work on the comments contributes to an in-depth understanding of the artistic features of Ostrovski´s plays; problems of the genre as an essential factor in the understanding of a dramatic work; specific attitude to history, confrontation of characters, mastery of psychological analysis, setting ethical problems.
The effect of intra- and interphase interactions on strength of polyamide-6-based composites
Authors: Tochiev D. S. , Dolbin I. V. , Sapaev Kh. Kh.
Published: November 2023

The effect of filler-filler and filler-polymer matrix interactions on the strength of polyamide-6-based composites has been studied. It is shown that the strengthening of interactions of both mentioned types leads to an increase in the strength of the investigated composites. Fillers with a layered structure are preferred over dispersed ones.
Marcado dimorfismo sexual de Heliura fenestrifer (Zerny, 1931) (Lepidoptera: Erebidae: Arctiinae: Ctenuchina)
Authors: Grados Juan
Published: November 2023

Se presenta el marcado dimorfismo sexual de Heliura fenestrifer (Zerny), revelado mediante el código de barras de ADN. Se redescribe el macho, y se describe por primera vez la hembra. Se dan a conocer los caracteres de los genitales de ambos sexos. Se discute la existencia de un espécimen rotulado como lectotipo de Heliura seitzi (Draudt), depositado en el Museo de Historia Natural de París y que corresponde a una hembra de H. fenestrifer.
Exotic and predatory: a spider (Araneae: Salticidae) that preys on native stingless bees (Hymenoptera: Meliponini) in Brazil
Authors: Trindade-Santos Matheus Eduardo , Lima Ramos Ramon , Silva Melo Tércio , Brescovit Antônio Domingos , de Oliveira Favízia Freitas
Published: November 2023

Pollination is a fundamental ecosystem service for the natural balance. Bees are the main biological agents for carrying out this service. It is known that the excessive simplification process of the landscape through anthropic action hinders the establishment of more sensitive species and favors generalist, exotic and invasive species. Thus, urbanization is a process that threatens native species. Thus, it is essential to understand the impact of this relationship, since it can foster tools that make cities more pleasant environments for pollinators. The aim of this study was to record the predation of a eusocial stingless bee species by an invasive exotic spider. Understanding this relationship is important from an environmental and economic point of view, since the preyed species is a potential pollinator of agricultural crops, and its rational breeding is widespread in Brazil.