bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Peningkatan Kualitas SDM Melalui Program PEKA (Produktif, Edukatif, Kooperatif dan Aksi)
Authors: Mulyadi  , Fadlilah Andi Hidayatul , Sudianto  , Nugraha Andika Prasetya
Published: March 2023

Tujuan dari kegiatan ini yaitu untuk memberitahukan kepada Pelajar SMK AL Jabar Batam, pentingnya meningkatkan kualitas SDM, dalam menghadapi dunia kerja, dan tantangan apa saja yang dihadapi dalam dunia kerja, sehingga pelajar bisa lebih mengenal potensi diri yang dimiliki. Kegitan ini dilakukan hasil Kerjasama MOU dan MoA antara Universitas ibnu sina dengan Sekolah Al Jabar Bengkong kota Batam. Sehingga bentuk Implikasi dari hasil Kerjasama dituangkan dengan  kegitatan pengabdian, Alasannya lebih fokus kepada Sumber Daya Manusia (SDM) hal ini yang sangat penting dikarenakan tinggi jumlah angka pencari kerja dikota batam, yang mana lulusan SMK/SMA yang paling dominan. Sehingga tidak dapat dipisahkan dari tujuan  meningkatkan SDM untuk mencapai tujuan organisasi, baik berupa Instansi Pemerintah, Akademik, perusahaan maupun industri. Semoga dengan pelaksanaan yang telah dilakukan bisa memberikan Semangat kepada para pelajar dalam menhadapi persaingan Global yang di hadapi setelah lulus dari sekolah. Juga kepada para guru-guru untuk dapat selalu meningkatkan Kulaitas SDM. Supaya para Guru dapat mengimplementasikan PEKA di pembelajaran.
Pengembangan Kewirausahaan Untuk Siswa SMA Islam Nabilah Batam Melalui Pelatihan Penyusunan Laporan Keuangan Sederhana
Authors: Mustika Ita , Ferdila  , Khadijah  , Sarmini  , M. Arpah  , Diana Nabella Septa
Published: March 2023

Pelaksanaan kegiatan pengabdian pada masyarakat ini dalam rangka mendukung mitra yaitu SMA Islam Nabilah Batam. SMA Islam Nabilah Batam adalah Sekolah Menengah Atas Swasta yang berada di Taman Dutamas, Baloi Permai, Kec. Batam Kota, Kota Batam. Permasalahan yang dihadapi mitra yaitu kurangnya motivasi dan pemahaman siswa akan pentingnya kewirausahaan. Kegiatan pengembangan kewirausahaan siswa SMA Islam Nabilah Batam melalui pelatihan penyusunan laporan keuangan sederhana bertujuan untuk mengembangkan jiwa wirausaha, motivasi, dan kreatifitas siswa SMA Islam Nabilah Batam serta pengetahuan yang cukup untuk menyusun laporan keuangan sederhana dengan harapan kedepannya mereka memiliki usaha sendiri untuk mengurangi tingkat pengangguran dan kemiskinan serta menciptakan lapangan kerja. Tim pengabdi membekali siswa dengan pengetahuan kewirausahaan dan keahlian terkait dengan penyusunan laporan keuangan sederhana dengan menggunakan metode ceramah, tanya jawab, diskusi dan evaluasi. Kegiatan dilaksanakan selama 2 hari yaitu tanggal 19 - 20 Januari 2023 dengan diikuti 35 peserta.
Pelatihan Pemanfaatan Tongkol Jagung untuk Media Tanam Jamur di Desa Muliasari Tanjung Lago Banyuasin
Authors: Sriati  , Priyanto Gatot , Junaidi Yulian , Arbi Muhammad
Published: March 2023

Pelatihan ini bertujuan meningkatkan motivasi, pengetahuan, ketrampilan dan kemampuan   Anggota KSU Trans Mekar Sari Mandiri dalam pemanfaatan tongkol jagung sebagai media tanam jamur. di Desa Muliasari, Tanjung Lago Banyuasin. Pelatihan dilakukan dengan penyampaian materi dan praktek memanfaatan tongkol jagung untuk media tanam jamur, kepada 20 orang peserta. Pre tes dan post tes dilakukan untuk evaluasi kegiatan. Hasil kegiatan menunjukkan adanya peningkatan motivasi, pengetahuan, ketrampilan dan kemampuan peserta tentang pemanfaatan tongkol agung untuk media tanam jamur. Peserta merespon baik materi yang disampaikan. Berdasarkan diskusi kelompok, permasalahan yang dihadapi dalam memanfaatkan limbah tongkol jagung adalah pemasaran produk, nilai gizi jamurnya, dan permodalan. Peserta berharap kedepannya ada pelatihan tentang pemanfaatan limbah jagung dan limbah pertanian lainnya, yang mencakup teknis pengolahan dan pemanfaatan limbah, aspek analisis usaha dan pemasaran serta membentuk Kelompok Usaha bersama.
Peningkatan Daya Tarik Desa Kare Kecamatan Kare Kabupaten Madiun melalui Pengembangan Ekowisata Berbasis Pasrtisipatif – Kolaboratif
Authors: Widiyanti Prihartini , Qulub Fitriyatul , Jayadi Akhmad , Sari Gadis Meinar
Published: March 2023

Desa Kare adalah salah satu desa di wilayah Kabupaten Madiun yang potensial untuk pengembangan wisata dan produk alam. Pengabdian masyarakat bertema ekowisata bertujuan (1) mengembangkan kawasan wisata berbasis partisipatif-kolaboratif, (2) meningkatkan pola kesadaran masyarakat terhadap kesehatan, (3) memberikan fasilitas kesehatan sesuai protokol kesehatan, (4) menarik minat para wisatawan melalui promosi media sosial, (5) menambah wawasan tentang cara pengolahan limbah dan produk unggulan ciri khas Desa Kare. Pelaksanaan kegiatan berlangsung dalam tiga level tahapan yaitu perencanaan kegiatan, pelaksanaan kegiatan dan tindak lanjut acara. Ekowisata dijalankan menitikberatkan pada peran aktif masyarakat setempat dan dalam kegiatan Program Pengembangan Desa Binaan (PPDB) telah dilakukan pembinaan produk dan kemasan terstandar destinasi wisata pada Unit Mikro Kecil dan Menengah (UMKM). Melalui pengmas PPDB, masyarakat setempat diberikan edukasi untuk menyiapkan masyarakat supaya sadar akan potensi alam untuk ikut menjaga dan melestarikan. Kegiatan secara berkelanjutan diharapkan untuk meningkatkan kesejahteraan serta taraf hidup masyarakat Desa Kare.
Diagnóstico da produção de alevinos na microrregião de Toledo no Paraná
Authors: Costa Leonan Coelho da , Feiden Aldi
Published: March 2023

Atualmente o estado do Paraná está em primeiro lugar na produção aquícola do país, estando essa produção concentrada na região Oeste. Dados da FAO apontam o contínuo crescimento da atividade, e os recentes investimentos estruturais na região Oeste, como a instalação do maior abatedouro de peixes do Brasil mostra a tendência regional de crescimento da atividade aquícola. O objetivo deste estudo foi diagnosticar através do levantamento de dados a produção da alevinagem na microrregião de Toledo. Previamente, foi realizado um levantamento sobre a quantidade de propriedades ativas existentes junto à ADAPAR e análise dos dados de produção da SEAB. A produção da microrregião de Toledo se concentra em torno da tilápia, espécie que assim como a nível nacional é a produzida em todo o regional estudado. Nos próximos anos deve-se incrementar ainda mais a produção principalmente expandindo as instalações e atraindo novas cooperativas. Assim, criando novos postos de trabalho no meio rural e na indústria.
Influence of Finishing Procedures on Surface Roughness and Biaxial Flexural Strength of High-translucent 4Y-PSZ, 5Y-PSZ, and 6Y-PSZ Monolithic Zirconia
Authors: DOĞRU Gülsüm , DEMİRALP Elif , KOÇAK Emre , ÖRKCÜ H. Hasan , AYDIN Prof. Dr. Cemal , YILMAZ Handan
Published: March 2023

Objective: This study aims to investigate the effects of glazing, polishing and polishing with a polishing paste of newly developed highly translucent materials on the flexural strength of these materials and aims to illuminate where there is not much study yet on the finishing procedures to be done.

Methods: Three different high translucency Y-PSZ (Yittria partially stabilized zirconia): KST (Katana STML), KUT (Katana UTML), NCQ (Nacera Pearl Q3 Multi-Shade) and one translucent 3Y-TZP (3-yttria stabilized tetragonal zirconia polycrystalline): NCMS (Nacera Pearl Multi-Shade) zirconia system were used. A total of 120 specimens were prepared in the form of discs with a diameter of 14 mm and dimensions of 1.2 ± 0.2

mm. Three experimental groups (n = 30) were formed from each type of material, using three finishing protocols: Diamond Polishing system (DP); Diamond Polishing system followed by Polishing Paste (PP); Glaze Application (GP). Surface Roughness (Ra) was measured by using a contact profilometer, and a biaxial flexural strength test was applied to determine their flexural strength. The obtained data were analyzed using the Weibull distribution. All results were evaluated statistically.

Results: For Ra values, there was a statistical difference between all the procedures applied in the KST material as in the NCQ material. However, there was no statistical difference between GP and PP procedures in Ra values in the NCMS material and between DP and PP procedures in the KUT material. The characteristic strengths of DP applied to NCMS and NCQ material, PP applied to KST, and KUT material had the highest value. The highest m values for DP were determined in KST, NCMS, NCQ materials, while in KUT material, PP was determined in the finishing procedure.

Conclusion: Finishing procedures have significant effects on surface roughness and flexural strength values for translucent zirconia materials. The lowest Ra value and the highest flexural strength were found in the DP group of NCMS. In KST and KUT materials, the highest flexural strength results were found in the PP procedure while NCQ was not affected by finishing procedures.
Motor Functional Level and Quality of Life According to Feeding Types in Children With Cerebral Palsy
Authors: CENGİZ Emre , SEREL ARSLAN Selen , DEMIR Numan , KARADUMAN Aynur Ayşe
Published: March 2023

Objective: The study aimed to compare motor functions and quality of life of children with cerebral palsy (CP), as well as anxiety and depression levels of caregivers according to the feeding types of the children.

Methods: The study included children with CP aged between 5-17 years. There were two groups: children with oral feeding (n=19) and children with non-oral feeding (n=16). Gross Motor Function Classification System (GMFCS) to classify children according to gross motor function, Gross Motor Function Measurement (GMFM) to evaluate gross motor functions, and parent-reported Pediatric Quality of Life Inventory to evaluate the quality of life of children were used. Beck Depression Inventory and Beck Anxiety Inventory were used to measuring caregivers’ anxiety and depression levels.

Results: Significant differences were found between groups regarding the GMFCS, GMFM, and parent-reported Pediatric Quality of Life scores of children in favor of children with oral feeding (p
Nanoparticles and Their Application in Prosthetic Dentistry
Authors: GÜRSOY Ezgi , YILMAZ Handan
Published: March 2023

In recent years, nanoparticles produced with nanotechnology have been widely used in many fields of medicine and dentistry such as prosthetic dental treatment. The advanced properties of nanoparticles such as biocompatibility, durability, solubility, large surface area, high stability, and thermal conductivity facilitate the development of dental materials. Compared to the traditional materials used, they can offer useful features, such as better diagnosis, treatment plans, improvement, and protection of oral health. Therefore, a better understanding of nanotechnology and nanoparticles is essential to appreciate how these materials can be utilised in our daily practice. This review provides an overview of nanoparticles and their applications in dentistry.
PERFORMANCE ANALYSIS BETWEEN INTERPRETED LANGUAGE-BASED (LARAVEL) AND COMPILED LANGUAGE-BASED (GIN) WEB FRAMEWORKS
Authors: Yang Jason Aaron , Aklani Syaeful Anas
Published: March 2023

Web frameworks are essential for web developers, allowing them to build web applications more efficiently and effectively. This research paper compared two web frameworks with different programming language implementations: interpreted programming language and compiled programming language. PHP/Laravel was chosen as the representative interpreted programming language, and Go/Gin was chosen as the representative compiled programming language, because they were the most popular based on their star counts on GitHub. Based on a research paper by the University of Minho, Go was nearly 10 times faster than PHP in terms of execution time. Despite this, PHP is still the most commonly used web technology among the top 1 million websites. The results of a series of tests comparing the two showed that Gin was over 86 times faster than Laravel in terms of requests per second and time per request. The choice of which web framework to use will depend on the specific needs and goals of the project. However, if performance is the only criterion, then Gin is a better choice than Laravel.
Pengaruh Implementasi Content Management System Terhadap Kecepatan Kinerja Menggunakan One Way Anova
Authors: Palupi Retno , Prasetya Andrew Eka
Published: March 2023

This study analyzes the performance speed measures of the Content Management System (CMS), namely Concrete, Drupal, Joomla and Wordpress. The purpose of this study was to determine whether there is a difference or not in the implementation of the four CMS. The data used are categorical and numeric types, categorical data is the CMS type and numerical data is obtained from observations made by recording the CMS installation on an offline server using the Active Presenter application, then calculating the installation time, admin system and database migration. The data obtained are then processed using the One Way ANOVA method in Statistical Product and Services Solution (SPSS) version 23. The indicator used for data sampling is the performance speed of the CMS which is measured in seconds. From data processing and analysis using One Way Anova, it can be concluded that from the CMS used (Concrete, Drupal, Joomla and Wordpress) there is no significant difference to the speed of CMS performance. Each CMS has advantages, but in terms of speed of performance there is no significant difference.
PERANCANGAN APLIKASI REKOMENDASI OBJEK PARIWISATA KOTA PEKANBARU BERBASIS ANDROID MENGGUNAKAN LOCATION BASED SERVICE UNTUK DINAS PARIWISATA KOTA PEKANBARU
Authors: Kreshna Jan Alif , Surya Ibnu , Kusuma Wardani Kartina Diah , Weslie Weslie
Published: March 2023

Tourists who visit the city of Pekanbaru not only come from within the country, but also from abroad. To provide services to people inside and outside Pekanbaru City, the Pekanbaru City Tourism Office currently has an official website as a medium to convey information about tourist attractions in Pekanbaru City. On the website, there is already a list of tourist attractions in the city of Pekanbaru. This research will develop applications that can be used by tourists who will visit tourist attractions in Pekanbaru City. Applications developed based on Android will provide recommendations for tourist attractions that are around application users by utilizing the Location Based Service feature. The application will also be equipped with a map and use the BellmanFord algorithm to get the shortest route to that location. It is hoped that the application generated from this research can be used as an alternative media that can be used by the Pekanbaru City Tourism Office in order to provide the best service for people inside and outside Pekanbaru City.
ANALISIS COVERAGE AREA JARINGAN 4G LTE TELKOMSEL, XL AXIATA DAN INDOSAT OOREDOO DI KECAMATAN BAYUNG LENCIR, KABUPATEN MUSI BANYUASIN, PROVINSI SUMATERA SELATAN.
Authors: Ariyadi Tamsir , Ariyudi Ariyudi
Published: March 2023

The research is to analyze the coverage area of ​​the 4G LTE network of telecommunications operators Telkomsel, XL Axiata, and Indosat Ooredo in Bayung Lencir District, Musi Banyuasin Regency, South Sumatra Province, Indonesia. The information obtained by the result of this research is expected to be useful for the public to determine and choose a telecommunications operator that has the widest coverage area and is a catalyst for improvement for telecommunications operators whose coverage area is not yet wide. This study will analyze the parameters of the 4G LTE network coverage area, namely: Reference Signal Received Power (RSRP) and Signal to Noise Ratio (SINR), on the 4G LTE network. The aim of this study to analyze the coverage area of ​​the 4G LTE network of Telkomsel, XL Axiata and Indosat Ooredoo in Bayung Lencir District, Musi Banyuasin Regency, South Sumatra Province using the G-NetTrack Pro application. The study was conducted in 9 villages/kelurahan in Bayung Lencir District, Musi Banyuasin District, South Sumatra Province. The results of the measurement of the coverage area parameters using the G-NetTrack Pro software were then analyzed statistically with the Single Factor Analysis of Variance. The results of the study, that  find RSRP and SINR parameters for cellular operators Telkomsel, XL Axiata, and Indosat Ooredoo, it was found that statistically the RSRP value between operators was not significantly different, which means that the RSRP values ​​for Telkomsel, XL Axiata, and Indosat Ooredoo were considered the same and the SINR parameter for operators Telkomsel, XL Axiata, and Indosat Ooredoo are statistically different where the SINR value of Telkomsel is the highest, followed by Indosat Ooredo at position number 2, and XL Axiata at position 3.
Review: Women in plant disease management
Authors: Gullino Maria Lodovica
Published: March 2023

Women first began to take a stance in science over 50 years ago, and since then, they have produced a great number of publications. However, the first step towards science was a matter of accrediting women as rightful members of the scientific community. During the late nineteenth and early twentieth centuries, women started to enter into graduate programmes, and such a step helped them to make a difference. In many cases and many countries, botanists and mycologists were, in some way, pioneering in the plant pathology discipline. This manuscript considers some of the women who led the way in plant pathology, with a special focus on those who also dealt with the early aspects of plant disease management. Women who were active in different geographical areas are featured, and an attempt has also been made to provide some less well-known stories. Moreover, the importance of women behind the scenes, as is the case for many lab and field technicians, whose lives have not been chronicled, is acknowledged. Finally, some suggestions are given on how to improve the present situation and increase the number of women in science as well as in technical positions, with special emphasis on the positive effect of female mentors and role models.
Elucidating the genomic history of commercially used Bacillus thuringiensis subsp. tenebrionis strain NB176
Authors: Schäfer Lea , Volk Frank , Kleespies Regina G. , Jehle Johannes A. , Wennmann Jörg T.
Published: March 2023

Bacillus thuringiensis subsp. tenebrionis (Btt) produces a coleopteran-specific crystal protoxin protein (Cry3Aa δ-endotoxin). After its discovery in 1982, the strain NB125 (DSM 5526) was eventually registered in 1990 to control the Colorado potato beetle (Leptinotarsa decemlineata). Gamma-irradiation of NB125 resulted in strain NB176-1 (DSM 5480) that exhibited higher cry3Aa production and became the active ingredient of the plant protection product Novodor® FC. Here, we report a comparative genome analysis of the parental strain NB125, its derivative NB176-1 and the current commercial production strain NB176. The entire genome sequences of the parental and derivative strains were deciphered by a hybrid de novo approach using short (Illumina) and long (Nanopore) read sequencing techniques. Genome assembly revealed a chromosome of 5.4 to 5.6 Mbp and six plasmids with a size range from 14.9 to 250.5 kbp for each strain. The major differences among the original NB125 and the derivative strains NB176-1 and NB176 were an additional copy of the cry3Aa gene, which translocated to another plasmid as well as a chromosomal deletion (~ 178 kbp) in NB176. The assembled genome sequences were further analyzed in silico for the presence of virulence and antimicrobial resistance (AMR) genes.
Atrial fibrillation episode status and incidence of coronary slow flow: A propensity score-matched analysis
Authors: Gao Ya-fang , Chen Yan , Wang Cheng-jian , Du Ying , Ding Ya-hui
Published: March 2023

Background

Previous studies have shown that patients with a history of atrial fibrillation (AF) have a higher risk of developing coronary slow flow (CSF). However, whether AF episode status affects the incidence of CSF has not been confirmed. This study investigated the correlation between AF episode status and the incidence of CSF.

Methods

We enrolled patients with AF who underwent coronary angiography for symptoms of myocardial ischemia between January 1, 2017, and April 30, 2022, at our institution and classified them according to whether they had an episode of AF in the perioperative period. The outcomes were defined the occurrence of CSF overall and in each of the three coronary arteries. The analysis was repeated after adjusting the baseline information by the propensity score matching method in a 1:1 ratio.

Results

214 patients who met the inclusion and exclusion criteria were included in the study (AF episode group: 100 patients, AF non-episode group: 114 patients). Before matching, age, left atrial size, ejection fraction, heart rate, CSF incidence, and mean corrected thrombolysis in myocardial infarction frame counts were higher in patients with intraoperative AF episodes than in patients without episodes. To prevent the dependent variable (CSF incidence) from being confounded by confounding factors, we matched the two groups for age, left atrial size, and ejection fraction. In the logistic regression analysis, the incidence of CSF was significantly higher in the intraoperative AF episode group (P = 0.010, OR = 2.327, 95% CI: 1.226–4.416) than in the non-episode group.

Conclusion

In patients with AF, AF episode status is significantly correlated with an increased overall incidence of CSF.
A comprehensive evaluation method for the site selection of new healthcare facilities in geological hazard-prone areas
Authors: Yu Miao , Hu Shi-yu , Cai Jian-min , Guo Peng-ning , Li Hai-bo , Xing Hui-ge
Published: March 2023

Healthcare facilities in geological hazard-prone areas not only are responsible for local basic medical services but also are the main provider of hazard emergency rescue work. The selection of their sites is further complicated by the need to consider both the equalization of regional medical services and resource allocation and the impact of geological hazards on site safety. Shimian County in Sichuan Province, a geological disaster-prone area, was chosen as the study area. First, suitability analysis of the construction land was used to determine the site alternatives for new healthcare facilities, and an evaluation index system of construction land suitability consisting of geological hazard susceptibility, slope and aspect was established. Then, the suitability was evaluated by the Ordered Weighted Averaging (OWA) operator, and the Analytic Hierarchy Process (AHP) and the quantitative method of Regular Increasing Monotone (RIM) were used to calculate the criterion weights and order weights in the Ordered Weighted Averaging operator respectively. The suitability results were classified into five levels: high, moderate, average, barely suitable, and unsuitable. Twelve site alternatives were identified in the highly and moderately suitable areas. Finally, a comprehensive evaluation index system consisting of indices such as construction land suitability and medical service accessibility was established, the PROMETHEE II method was conducted to comprehensively evaluate the site alternatives, and ranked results for the 12 site alternatives were obtained. These ranked results were analyzed by subindexes and Graphical Analysis for Interactive Aid (GAIA) to obtain a score for each alternative index and its similarity to the alternative, which could significantly help decision-making. This study achieves reasonable and scientific site selection for healthcare facilities in geological hazard-prone areas, and the results can provide references for relevant decision-makers.
Karst landslides detection and monitoring with multiple SAR data and multi-dimensional SBAS technique in Shuicheng, Guizhou, China
Authors: Sun Rongrong , Zhao Chaoying , Li Bin , Chen Hengyi , Chen Liquan
Published: March 2023

Shuicheng District is a karst mountain area, located in Guizhou Province, China. Its fragile stratum and frequent underground mining activities makes it prone to landslides. Owning to its wide coverage and frequent revisit, the InSAR technology has advantages in potential landslide identification and deformation monitor. However, affected by dense vegetation and atmospheric delay, it is much difficult to get sufficient effective targets to derive the deformation in this area. Besides, deformation derived from single orbit SAR data can result in the missing identification of some potential landslides and the misinterpreting of the real kinematics process of landslides. In this study, the multi-source SAR data, atmospheric error correction by quadratic tree image segmentation method, and phase-stacking method were selected to derive the surface deformation of this area. Besides, DS-InSAR and MSBAS method were combined to derive the deformation of Pingdi landslide. First, the potential landslides in this area were identified, surface deformation result, optical remote sensing images and geomorphological features were jointly considered. Then, the landslide distribution characteristics was analyzed in terms of slope, elevation and stratum. After that, the deformation along the LOS direction was acquired using the DS-InSAR method. The MSBAS method was used to retrieve the two-dimensional deformation of Pingdi landslide. Finally, the comprehensive analysis of triggering factors and failure process were conducted according to the spatial-temporal deformation characteristics and field investigation. The results indicated that landslides in Shuicheng district were mostly located in the junction of T1 and P3 stratum and mining related. Mining activity was the main cause of the Pingdi landslide deformation, the precipitation was the driving factor of the landslide instability. The research provides an insight into the explore the unstable slope distribution characteristic and the failure process of the landslides.
Survival and human resource strategies of private higher education in facing an era of change: Insight from Indonesia
Authors: Ramaditya Muhammad , Effendi Syahrul , Burda Agustian
Published: March 2023

Purpose Survival in private higher education is possible if universities have the superior talent to withstand the shocks of change. Hence, the human resource strategy is an essential part of surviving. Thus, this study aims to identify and determine the implementation of survival and human resource strategies in Indonesia’s private higher education is facing an era of change. The research method used is a descriptive qualitative approach. In collecting data, researchers used the archival method. The data is sourced from news, a total of 602 data sources, and obtained from online publications through trusted news and media. This study found six strategies of survival and human resource by private higher education in Indonesia to encounter an era of change: Efficiency; Quality Assurance; Customer Retention Program; Intensive Marketing Program; Opening of New Programs; Mergers, and Acquisitions. This research is expected to provide an extension of the survival and human resource strategies implemented by private universities in Indonesia in facing an era of change.
Autophagy and its therapeutic potential in diabetic nephropathy
Authors: Han Yu-Peng , Liu Li-Juan , Yan Jia-Lin , Chen Meng-Yuan , Meng Xiang-Fei , Zhou Xin-Ru , Qian Ling-Bo
Published: March 2023

Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most significant microvascular complication of diabetes and poses a severe public health concern due to a lack of effective clinical treatments. Autophagy is a lysosomal process that degrades damaged proteins and organelles to preserve cellular homeostasis. Emerging studies have shown that disorder in autophagy results in the accumulation of damaged proteins and organelles in diabetic renal cells and promotes the development of DN. Autophagy is regulated by nutrient-sensing pathways including AMPK, mTOR, and Sirt1, and several intracellular stress signaling pathways such as oxidative stress and endoplasmic reticulum stress. An abnormal nutritional status and excess cellular stresses caused by diabetes-related metabolic disorders disturb the autophagic flux, leading to cellular dysfunction and DN. Here, we summarized the role of autophagy in DN focusing on signaling pathways to modulate autophagy and therapeutic interferences of autophagy in DN.
Characteristics of small pancreatic neuroendocrine tumors and risk factors for invasion and metastasis
Authors: Mei Wentong , Cao Feng , Lu Jiongdi , Qu Chang , Fang Zhen , Li Jia , Li Fei
Published: March 2023

Background

The number of people with small pancreatic neuroendocrine tumors (pNETs) (tumors with a diameter less than or equal to 2 cm) is gradually increasing, but the selection of treatment strategy is still controversial. Our aim was to characterize small pNETs with a poor prognosis and to define the impact of aggressive small pNETs on survival and the risk factors for the development of invasive disease.

Methods

Patients with pNETs diagnosed between 2004 and 2019 and a tumor diameter of 2 cm or less were selected from the SEER Registry. Kaplan–Meier survival analysis was used to identify the factors affecting patient survival, and binary logistic regression was used to identify the associated risk factors.

Results

A total of 3261 patients with pNETs were enrolled in the study. Both older and younger patients benefited from surgery. Regional invasion occurred in 10% of the patients, and distant metastases occurred in 9% of the patients, but in both categories, those who underwent surgery had better survival outcomes than those who did not. There was no difference in survival between patients with a tumor diameter of 1–2 cm and those with a tumor diameter of less than 1 cm, and there was no difference in survival between patients with functional and nonfunctional small pNETs. However, the survival of patients with pNETs in the head of the pancreas was worse than that of patients with tumors in other parts of the pancreas. Survival was worse in elderly patients and in those with poorly differentiated and undifferentiated tumors. Lymphatic metastasis, regional invasion, and distant metastasis all worsened the prognosis of patients. The presence or absence of neuroendocrine function, the degree of tumor differentiation, and the location of the tumor were associated with the risk of lymphatic metastasis and regional invasion; the risk factors for distant metastasis were associated with the degree of differentiation and tumor location.

Conclusion

The pNETs ≤ 2 cm in diameter could be still aggressive, and patient prognosis worsens after invasive disease develops. Attention to the characteristics of aggressive tumors can improve patient survival.
The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses
Authors: Bourebaba Lynda , Serwotka-Suszczak Anna , Pielok Ariadna , Sikora Mateusz , Mularczyk Malwina , Marycz Krzysztof
Published: March 2023

Background

Equine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis. Among the several molecular mechanisms underlying EMS pathogenesis, increased negative insulin signalling regulation mediated by protein tyrosine phosphatase 1 B (PTP1B) has emerged as a critical axis in the development of liver insulin resistance and general metabolic distress associated to increased ER stress, inflammation and disrupted autophagy. Thus, the use of PTP1B selective inhibitors such as MSI-1436 might be considered as a golden therapeutic tool for the proper management of EMS and associated conditions. Therefore, the present investigation aimed at verifying the clinical efficacy of MSI-1436 systemic administration on liver metabolic balance, insulin sensitivity and inflammatory status in EMS affected horses. Moreover, the impact of MSI-1436 treatment on liver autophagy machinery and associated ER stress in liver tissue has been analysed.

Methods

Liver explants isolated from healthy and EMS horses have been treated with MSI-1436 prior to gene and protein expression analysis of main markers mediating ER stress, mitophagy and autophagy. Furthermore, EMS horses have been intravenously treated with a single dose of MSI-1436, and evaluated for their metabolic and inflammatory status.

Results

Clinical application of MSI-1436 to EMS horses restored proper adiponectin levels and attenuated the typical hyperinsulinemia and hyperglycemia. Moreover, administration of MSI-1436 further reduced the circulating levels of key pro-inflammatory mediators including IL-1β, TNF-α and TGF-β and triggered the Tregs cells activation. At the molecular level, PTP1B inhibition resulted in a noticeable mitigation of liver ER stress, improvement of mitochondrial dynamics and consequently, a regulation of autophagic response. Similarly, short-term ex vivo treatment of EMS liver explants with trodusquemine (MSI-1436) substantially enhanced autophagy by upregulating the levels of HSC70 and Beclin-1 at both mRNA and protein level. Moreover, the PTP1B inhibitor potentiated mitophagy and associated expression of MFN2 and PINK1. Interestingly, inhibition of PTP1B resulted in potent attenuation of ER stress key mediators’ expression namely, CHOP, ATF6, HSPA5 and XBP1.

Conclusion

Presented findings shed for the first time promising new insights in the development of an MSI-1436-based therapy for proper equine metabolic syndrome intervention and may additionally find potential translational application to human metabolic syndrome treatment.
Battery data integrity and usability: Navigating datasets and equipment limitations for efficient and accurate research into battery aging
Authors: Gering Kevin L. , Shirk Matthew G. , Kim Sangwook , Walker Cody M. , Dufek Eric J. , Wang Qiang
Published: March 2023

A tremendous commitment of resources is needed to acquire, understand and apply battery data in terms of performance and aging behavior. There are many state of performance (SOP) and state of health (SOH) metrics that are useful to guide alignment of batteries to end-use, yet how these metrics are measured or extracted can make the difference between usable, valuable datasets versus data that lacks the necessary integrity to meet baseline confidence levels for SOP/SOH quantification. This work will speak to 1) types of data that support SOP and SOH evaluations on mechanistic terms, 2) measurement conditions needed to assure high data integrity, 3) equipment limitations that can compromise data high fidelity, and 4) the impact of cell polarization on data quality. A common goal in battery research and field use is to work from a data platform that supports economical paths of data capture while minimizing down-time for battery diagnostics. An ideal situation would be to utilize data obtained during normal daily use (“pulses or cycles of convenience”) without stopping the daily duty cycles to perform dedicated SOP/SOH diagnostic routines. However, difficulties arise in trying to make use of daily duty cycle data (denoted as cycle-by-cycle, CBC) that underscores the need for standardization of conditions: temperature and duty cycles can vary over the course of a day and throughout a week, month and year; polarization can develop within an immediate cycle and throughout successive cycles as a hysteresis. If CBC data is envisioned as a data source to determine performance and aging trends, it should be recognized that polarization is a frequent consequence of CBC and thus makes it difficult to separate reversible and irreversible components to metrics such as capacity loss and resistance increase over aging. Since CBC conditions can have a major impact on data usability, we will devote part of this paper to CBC data conditioning and management. Differential analyses will also be discussed as a means to detect changing trends in data quality. Our target cell chemistries will be lithium-ion types NMC/graphite and LMO/LTO.
Power system intelligent operation knowledge learning model based on reinforcement learning and data-driven
Authors: Zhou Yibo , Mu Gang , An Jun , Zhang Liang
Published: March 2023

With the expansion of power grid scale and the deepening of component coupling, the operation behavior of power system becomes more and more complex, and the traditional function decoupling dispatching architecture is not available anymore. Firstly, this paper studies the corresponding relationship between reinforcement learning method and power system dispatching decision problem, and constructs the artificial intelligent dispatching knowledge learning model of power system based on reinforcement learning (AIDLM). Then, a data-driven intelligent dispatching knowledge learning method is proposed, and interpretable dispatching decision knowledge is obtained. Finally, a knowledge efficiency evaluation indexes is proposed and used to guide the extraction of original acquired knowledge. The intelligent economic dispatching problem of a regional power grid is analyzed. The results show that the AIDLM method can intelligently give the dispatching strategy of power generation according to the time series changing load, which effectively reduces the cost of power generation in the grid. The method proposed in this paper can make up for the shortcomings of traditional dispatching methods and provide strong support for modern power system dispatching.
High entropy nanomaterials for energy storage and catalysis applications
Authors: Modupeola Dada , Popoola Patricia
Published: March 2023

In the past decade, high entropy alloys have been a research field of interest largely attributed to the enormous possibilities in alloy compositions, solid solution microstructures, and enhanced properties. The progress accomplished so far in the innovative growth and development of the mechanical, nanomechanical, chemical, electrochemical properties for energy storage systems using high entropy alloys on the nanoscale has limited reports in the literature. Mastering the synthesis of high entropy alloys is the deciding factor, if not the holy grail, when interested in a new material. For nanoparticles, in particular, this is true. Hence, the study on the production of high entropy alloy nanoparticles (HE-NPs) and the impact of synthesis on the structure of the resulting nanomaterial is valid for newly emerging components like HEA-NPs and the linkages between synthesis, structure, and property are essential for creating HEA-NP-based applications for energy storage applications, requiring the creation of a fundamental protocol to enable their mass manufacture and efficiency in service. In this study, we have presented a straightforward review of high entropy alloys, recent advances in high entropy nanoparticles and their various syntheses for energy and catalysis applications.
Managerial ability, compensation incentives, and corporate performance
Authors: Chen Sidi , Fan Min , Wang Xiaohong , Fan Yaojun , Chen Sze-Ting , Ren Shichi
Published: March 2023

Enterprise managers play a decisive role in management decisions. With the emergence of managerial ability measurement methods, the influence of managerial ability on enterprise development has received wide attention. Taking Chinese A-share listed companies from 2007 to 2019 as samples, this paper uses a fixed-effect model to examine the impact of management abilities on corporate performance and studies the moderating effect of compensation incentives on this impact. It is found that managerial ability has a significant positive correlation with the performance of listed companies, and this positive correlation is more obvious when the management has higher compensation incentives. Further research shows that higher ability management helps improve the performance of firms with low financing constraints but has no significant effect on the performance of firms with high financing constraints. In addition, compared with state-owned enterprises, the managerial ability of non-state-owned enterprises can promote the improvement of enterprise performance. This paper studies the impact of managerial ability on firm performance from the perspective of compensation incentives, enriching the related literature on managerial ability and firm performance.
Digitalization, financing constraints and firm performance
Authors: Kuang Yiming , Fan Min , Fan Yaojun , Jiang Yan , Bin Jie
Published: March 2023

The development of low-level digital technology and communication technology such as “huge wisdom moving cloud” has driven the rise of digital economy, and various fields of social economy have gradually realized deep integration with digital technology. From the micro level of enterprises, digitalization transforms business activities such as research and development, production, supply chain and sales, and forms new data resources to help enterprises achieve lean management through data integration and analysis. To investigate whether digitalization ultimately affects firm performance, this study conducted theoretical discussions, selected Chinese listed companies to study, and empirically tested the relationship. Research has found that digitisation does boost corporate performance. After the robustness test, the conclusion remains the same. To deepen the understanding of the impact of digitalization on corporate performance, a mechanism analysis is also performed in this study. We found that digitization improves corporate performance by improving corporate innovation. In addition, we carried out an applicability analysis. We find that digitalization has a greater impact on firm performance in non-state-owned enterprises and those whose executives have an information technology background. Finally, by means of the economic consequences test, we find that the improvement in corporate performance caused by the growth of the digital hierarchy improves the corporate debt structure in the future. The findings of this study enrich theories related to digitalization and improve empirical evidence for the positive externalities of digitalization.
A novel study on bean common mosaic virus accumulation shows disease resistance at the initial stage of infection in Phaseolus vulgaris
Authors: Çelik Ali , Emiralioğlu Orkun , Yeken Mehmet Zahit , Çiftçi Vahdettin , Özer Göksel , Kim Yoonha , Baloch Faheem Shehzad , Chung Yong Suk
Published: March 2023

Accurate and early diagnosis of bean common mosaic virus (BCMV) in Phaseolus vulgaris tissues is critical since the pathogen can spread easily and have long-term detrimental effects on bean production. The use of resistant varieties is a key factor in the management activities of BCMV. The study reported here describes the development and application of a novel SYBR Green-based quantitative real-time PCR (qRT-PCR) assay targeting the coat protein gene to determine the host sensitivity to the specific NL-4 strain of BCMV. The technique showed high specificity, validated by melting curve analysis, without cross-reaction. Further, the symptoms development of twenty advanced common bean genotypes after mechanical BCMV-NL-4 infection was evaluated and compared. The results showed that common bean genotypes exhibit varying levels of host susceptibility to this BCMV strain. The YLV-14 and BRS-22 genotypes were determined as the most resistant and susceptible genotypes, respectively, in terms of aggressiveness of symptoms. The accumulation of BCMV was analyzed in the resistant and susceptible genotypes 3, 6, and 9 days following the inoculation by the newly developed qRT-PCR. The mean cycle threshold (Ct) values showed that the viral titer was significantly lower in YLV-14, which was evident in both root and leaf 3 days after the inoculation. The qRT-PCR thus facilitated an accurate, specific, and feasible assessment of BCMV accumulation in bean tissues even in low virus titers, allowing novel clues in selecting resistant genotypes in the early stages of infection, which is critical for disease management. To the best of our knowledge, this is the first study of a successfully performed qRT-PCR to estimate BCMV quantification.
Clinical and genetic characterization of pediatric patients with Wilson’s disease from Yunnan province where ethnic minorities gather
Authors: Wang Yanjun , Fang Jiahui , Li Bin , Li Chongyang , Liu Shan , He Juan , Tao Lvyan , Li Cuifen , Yang Ya , Li Li , Xiao Shufang
Published: March 2023

Background: Wilson’s disease (WD) is an autosomal recessive disease that is caused by mutations in the ATP7B (a copper-transporting P-type ATPase) gene. The disease has a low prevalence and is characterized by a copper metabolism disorder. However, various characteristics of the disease are determined by race and geographic region. We aimed to discover novel ATP7B mutations in pediatric patients with WD from Yunnan province, where there is a high proportion of ethnic minorities. We also performed a comprehensive analysis of ATP7B mutations in the different ethnic groups found in Southwest China.

Methods: We recruited 45 patients who had been clinically diagnosed with WD, from 44 unrelated families. Routine clinical examinations and laboratory evaluations were performed and details of age, gender, ethnic group and symptoms at onset were collected. Direct sequencing of the ATP7B gene was performed in 39 of the 45 patients and their families.

Results: In this study, participants came from seven different ethnic groups in China: Han, Bai, Dai, Zhuang, Yi, Hui and Jingpo. Three out of ten patients from ethnic minorities presented with elevated transaminases, when compared to the majority of the Han patients. Forty distinct mutations (28 missense, six splicing, three non-sense, two frameshift and one mutation of uncertain significance) were identified in the 39 patients with WD. Four of the mutations were novel and the most frequent mutation was c.2333G > T (p.R778L, allelic frequency: 15.38%). Using the phenotype-genotype correlation analysis, patients from ethnic minorities were shown to be more likely to have homozygous mutations (p = 0.035) than Han patients. The patients who carried the c.2310C > G mutation had lower serum ceruloplasmin levels (p = 0.012). In patients with heterozygous mutations, c.3809A > G was significantly associated with ethnic minorities (p = 0.042). The frequency of a protein-truncating variant (PTV) in Han patients was 34.38% (11/32), while we did not find PTV in patients from ethnic minorities.

Conclusion: This study revealed genetic defects in 39 pediatric patients with WD from Yunnan province. Four novel mutations were identified and have enriched the WD database. We characterized the genotypes and phenotypes in different minorities, which will enhance the current knowledge on the population genetics of WD in China.