bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical laboratory strategies for managing pandemic outbreaks
Authors: Alotaibi Maaly Zayed , Alsoor Seham Sultan , Alnajrani Amani Sameer , Mobarki Amjad Ahmed , Albalawi Afrah Ali , Alsuwaidi Badriyh Furaih , Alsedmi Alaa Yehey , Asiri Mohammed Alhussain
Published: February 2024

This review article comprehensively examines clinical laboratory strategies for managing pandemic outbreaks, with a particular focus on lessons learned from the COVID-19 pandemic. Drawing upon an extensive analysis of existing literature from databases such as PubMed, Web of Science, and Cochrane, as well as manual searches on Google Scholar, the study aims to provide insights into key aspects of pandemic preparedness and response. The literature review encompasses diverse combinations of medical terminology, emphasizing the role and response of clinical laboratories during pandemics. The primary focus areas include rapid test development and deployment, increased testing capacity, sample collection, and transportation protocols, data management, personnel safety, resource allocation, adaptability, and quality control measures. The inclusion of articles in this study adheres to rigorous criteria, ensuring a thorough and robust review process. The findings highlight the critical importance of rapid and accurate diagnostic testing, especially in the early stages of a pandemic, to facilitate timely interventions and containment. Efficient sample collection and transportation systems are crucial for maintaining the integrity of specimens, while advanced data management and reporting systems contribute to informed decision-making. Adaptability and flexibility are identified as indispensable traits for navigating the dynamic challenges of a pandemic, and stringent quality control measures are foundational for upholding the accuracy of diagnostic testing. The review underscores the collaborative efforts needed among clinical laboratories, public health agencies, and research institutions to strengthen global pandemic preparedness and response strategies.
Overview of JN.1 the variant of interest: strengths, weaknesses, opportunities, and threats analysis
Authors: Krishnasamy Narayanasamy , Sundar Jasmine S. , Dev Deivendiran Sulochana Monica , Govindarajulu Srinivas
Published: February 2024

Amidst the ongoing global battle against the COVID-19 pandemic, the World Health Organization (WHO) emphasizes monitoring variants of interest (VOIs) of the SARS-CoV-2 virus. The JN.1 variant, initially considered within the framework of BA.2.86, has rapidly gained global prevalence, prompting its reclassification as an independent VOI. This study assesses the strengths, weaknesses, opportunities, and threats (SWOT) analysis of the JN.1 variant. A literature review from PubMed, and expert opinions from newspaper articles were utilized for information collection. The study incorporates a comprehensive SWOT analysis, associated with the JN.1 variant. The JN.1 variant's global dominance is marked by exponential increases in COVID-19 cases, impacting healthcare systems. While strengths include global guidance, vaccine effectiveness, and a robust surveillance system, weaknesses encompass wastewater analysis, seasonal impacts, and immune escape capabilities. Opportunities lie in continuous vaccination campaigns, monitoring, research, vaccine adaptation, and adaptive strategies. Threats include co-circulation with respiratory diseases, lower antibody responses, and potential global spread. The study underscores the importance of clear public communication, continuous surveillance, and research efforts in addressing the challenges posed by the JN.1 variant. Recommendations include assessing vaccine effectiveness, updating strategies and fostering global collaboration for a more effective response.
PLANIFICACIÓN COLABORATIVA
Authors: Francisco Antonio Enrique
Published: February 2024

La experiencia que a continuación se expone, está situada en la Escuela Normal Bilingüe e Intercultural de Oaxaca, México; con estudiantes de la licenciatura en Educación Preescolar y Primaria Intercultural Bilingüe. Se muestra la posibilidad del trabajo por proyecto integral de aprendizaje, con los alumnos que cursan el tercer semestre en la formación inicial de los futuros docente en educación básica, donde se trabaja con ellos, la cosmovisión de los pueblos originarios, y en complementariedad con los contenidos escolares, estableciendo un diálogo de saberes; recuperando las experiencias de aprendizaje desarrollados en los contextos pluriculturales y multilingües, para un aprendizaje situado y contextual.
PRESENÇA E A SIMBOLOGIA DAS FLORES NA ICONOGRAFIA CEMITERIAL
Authors: Comerlato Fabiana
Published: February 2024

Não de aplica.
Multi-Modal Deep Learning based Metadata Extensions for Video Clipping
Authors: Kim Woo-Hyeon , Kim Geon-Woo , Kim Joo-Chang
Published: February 2024

General video search and recommendation systems primarily rely on metadata and personal information. Metadata includes file names, keywords, tags, and genres, among others, and is used to describe the video's content. The video platform assesses the relevance of user search queries to the video metadata and presents search results in order of highest relevance. Recommendations are based on videos with metadata judged to be similar to the one the user is currently watching. Most platforms offer search and recommendation services by employing separate algorithms for metadata and personal information. Therefore, metadata plays a vital role in video search. Video service platforms develop various algorithms to provide users with more accurate search results and recommendations. Quantifying video similarity is essential to enhance the accuracy of search results and recommendations. Since content producers primarily provide basic metadata, it can be abused. Additionally, the resemblance between similar video segments may diminish depending on its duration. This paper proposes a metadata expansion model that utilizes object recognition and Speech-to-Text (STT) technology. The model selects key objects by analyzing the frequency of their appearance in the video, extracts audio separately, transcribes it into text, and extracts the script. Scripts are quantified by tokenizing them into words using text-mining techniques. By augmenting metadata with key objects and script tokens, various video content search and recommendation platforms are expected to deliver results closer to user search terms and recommend related content.
Conformité des pratiques de reporting en matière de développement durable avec le cadre de la Global Reporting Initiative : Une analyse du secteur mondial de la santé
Authors: Macuda Małgorzata
Published: February 2024

L'Objectif : Le but de cet article est d'étudier la conformité des pratiques de reporting en matière de développement durable pour le secteur de la santé avec le cadre de la Global Reporting Initiative (GRI).
Conception/méthodologie/approche : 2440 rapports de développement durable publiés entre 1999 et 2019 par 632 organisations de santé dans le monde entier ont été examinés à l'aide d'une analyse de contenu. Une méthodologie de recherche descriptive, comprenant une revue de la littérature, a été appliquée afin d'atteindre l'objectif déclaré.
Résultats : Les résultats indiquent que (1) la tendance croissante des organisations de santé à publier des rapports de développement durable conformément aux lignes directrices GRI ou aux standards GRI est remarquée chaque année ; et que (2) 68% des 2440 rapports publiés par les organisations de santé (services et produits) sont conformes au cadre GRI. Les tendances observées concernant la conformité des rapports avec le cadre GRI pourraient fournir une image complète des pratiques de divulgation des informations non financières dans le secteur mondial de la santé. L'article offre une étude intéressante sur les rapports de développement durable qui sont les instruments les plus couramment utilisés par les organisations pour rendre compte de leurs performances économiques, environnementales et sociales.
Originalité/valeur : Cette recherche contribue à une littérature croissante sur la standarisation des rapports de développement durable dans le secteur mondial de la santé en fournissant une vision empirique de l'utilisation réelle du cadre GRI. L'article comble une lacune en matière de recherche dans le domaine des pratiques de reporting extra-financier des organisations de santé du monde entier.
Correspondance entre formations et emplois : Cas des diplômés de la FSHSE/ULSHB
Authors: Traoré Souaïbou Samba Lamine , Berthé Bakary , Dembélé Fatoumata
Published: February 2024

L'objectif : L'objectif principal de ce papier était d'identifier les facteurs qui sont susceptibles d'influencer les diplômés de la FSHSE pour accéder à un emploi lié au domaine de formation initiale.
Conception/méthodologie/approche : Les données utilisées dans le cadre de cette étude sont issues d'une enquête personnelle, qui a été réalisée auprès de deux cent trois (203) diplômés de la FSHSE, l'approche méthodologique s'appuie principalement sur la construction et l'estimation d'un modèle de régression logistique multinomial pour l'identification des facteurs.
Résultats : Les résultats obtenus à travers l'estimation du modèle logistique multinomial, ont révélé un certain nombre de facteurs expliquant dans l'accès des diplômés à l'emploi correspondant à leur domaine de formation initiale. Ces facteurs sont à savoir : la filière de formation, le type de diplôme, la tranche d'âge, le stage, le milieu de résidence, l'origine sociale des parents. Originalité/valeur : Comme apport théorique, cette étude vient d'enrichir la littérature théorique soutenue par les théoriciens du capital humain et les conclusions qui ont été avancées dans d'autres travaux empiriques. Au plan méthodologique, l'originalité de cette étude réside du fait qu'on s'intéresse au problème d'adéquation entre formations initiales et emplois dans le cas spécifique de la FSHSE. En dehors des contributions théoriques et méthodologiques enrichissantes, notre travail de recherche permet également de faire des propositions aux responsables de la FSHSE et éclairer les décideurs d'emplois sur le problème d'adéquation entre formations et emplois afin de trouver des solutions.
Samuel Beckett a Irlandia
Authors: Uchman Jadwiga
Published: February 2024

Artykuł stanowi bardzo obszerne i szczegółowe studium złożonych relacji Becketta z Irlandią jako krajem oraz z irlandzkością pojmowaną jako stan ducha. Autorka wyczerpująco omawia fakty biograficzne, wypowiedzi Becketta oraz krytyków, a także same dramaty, aby oddać całą niejednoznaczność i nerwowość relacji autora Czekając na Godota do własnego kraju. Przy okazji artykuł staje się wyczerpującym wprowadzeniem do całej twórczości Irlandczyka, wskazując jednocześnie na tak ważne elementy jego dzieła i krytycznej recepcji, jak: problem języka, problem przekładu czy rolę biografii w kształtowaniu się twórczości tego autora.
Awareness of parents of preschool children about selected heavy metals in food
Authors: Dolibóg Magdalena , Osmala-Kurpiewska Weronika
Published: February 2024

Wstęp

Działalność człowieka przyczyniła się do szerokiego rozpowszechnienia metali ciężkich w środowisku naturalnym. Skutki narażenia na metale ciężkie mogą się ujawnić dopiero po upływie wielu lat. Narażenie dzieci na metale ciężkie drogą pokarmową może stanowić istotne ryzyko zdrowotne, dlatego wiedza oraz postawy zdrowotne rodziców i opiekunów prawnych mają niebagatelne znaczenie w zakresie minimalizacji ryzyka zdrowotnego dzieci. Celem pracy była ocena poziomu wiedzy rodziców na temat metali ciężkich, ich występowania w żywności oraz zagrożeń dla zdrowia dzieci, wynikających ze spożywania żywności zanieczyszczonej metalami ciężkimi.

Materiał i metody

Narzędzie badawcze stanowił autorski kwestionariusz ankiety, składający się z części „metryczka” oraz pytań zamkniętych, głównie jednokrotnego wyboru. Grupę badaną stanowiło 100 rodziców z dwóch placówek przedszkolnych zlokalizowanych na terenie województwa śląskiego. Wyniki kwestionariusza ankiety zostały opracowane w programie Microsoft Office Excel 2019. Za pomocą programu Statistica 13 (StatSoft) wykonano analizę statystyczną (test chi-kwadrat), a istotność statystyczną przyjęto na poziomie α = 0,05.

Wyniki

Rodzice dzieci w wieku przedszkolnym nie są świadomi zagrożeń związanych z ekspozycją na metale ciężkie. Większość respondentów nie zapoznawała się z informacjami ogólnymi na temat obecności metali ciężkich w produktach spożywczych.

Wnioski

Świadomość rodziców dzieci w wieku przedszkolnym dotycząca wybranych metali ciężkich występujących w żywności jest niska. Wskazane jest wdrożenie działań edukacyjnych w celu zwiększenia poziomu wiedzy rodziców na temat możliwych następstw zdrowotnych i sposobów zmniejszania ryzyka zdrowotnego wynikającego z narażenia na metale ciężkie drogą pokarmową.
Economia Circular, Gestão da Cadeia de Suprimentos e Commodities: Agenda de Pesquisa no Contexto Sustentável
Authors: Johann Daiane , Santos Ruan Carlos dos , Tutida Alessandra Yula
Published: February 2024

Objetivo: A pesquisa aborda a implementação da economia circular na cadeia de suprimentos sustentável, viabilizado por meio dos comodities no contexto sustentável. O artigo busca maiores níveis de sustentabilidade, atendendo a forte mobilização da sociedade por produtos com melhores desempenhos ambientais.

Método: Apesar de muitos estudos abordarem separadamente os conceitos, poucos estudos avançam na visão integrada de funcionamento da cadeia de suprimentos de produtos circulares. A revisão sistemática da literatura buscou relacionar a integração dos conceitos identificando aspectos chaves das partes interessadas, processos e ferramentas, que podem ser sincronizados para auxiliar as organizações na implantação do ambiente circular nas operações da cadeia de suprimentos e gerar ganhos de sustentabilidade.

Resultados: A evolução da cadeia de suprimentos como um resultado das necessidades de competição dos produtores, visando melhorias de mercado e redução de custos, a geração de valor ao longo da cadeia está muito focada na entrega de especificidade ao cliente. Por isso, a cadeia de suprimentos é sustentável, pois precisa obter um bom desempenho em medidas financeiras tradicionais, incluindo que se trata de sustentabilidade na cadeia de suprimentos para formar as três dimensões: social, ambiental e econômica.

Conclusão: O trabalho abre caminho para pesquisas futuras e aplicações práticas, considerando a necessidade de funcionamento sistêmico de tecnologias que promovam a atuação conjunta e ambiente de cooperação entre organizações, que favoreçam ganhos de sustentabilidade.
Current state of endovascular repair of thoracoabdominal aortic aneurysms
Authors: Rodrigues Diego V. S. , Lima Guilherme B. Barbosa , DeMartino Randall R. , Mendes Bernardo C.
Published: February 2024

Thoracoabdominal aortic aneurysm (TAAA) is a severe and complex condition with multifactorial etiology that can lead to life-threatening complications. Its treatment is genuinely complex irrespective of the chosen technique, open or endovascular repair. Fenestrated-branched endovascular aneurysm repair (F/B-EVAR) has been increasingly accepted in patients with suitable anatomy, resulting in outcomes compared to or superior to open repair. The selection of patients, judicious surgical planning, and device selection are paramount to achieving successful treatment. The field of TAAA repair is continuously evolving with ongoing research and the development of new techniques and devices to further improve patient outcomes. This paper aims to present a review of endovascular TAAA treatment, summarizing anatomical and clinical features relevant to technical performance and treatment indications.
Newborn screening in South Africa: the past, present, and plans for the future
Authors: Malherbe Helen L. , Bonham Jim , Carrihill Michelle , Chetty Karmani , Conradie Engela H. , Dercksen Marli , Goeiman Hilary , Gomes Marianne C. M. , Klopper Brenda , McKerrow Neil , Padilla Carmencita , Pillay Tahir S. , Roussot Bronwyn , Satekge Tumelo M. , Urban Michael , van der Watt George , Vreede Helena , Webster Dianne , Zampoli Marco , Vorster Barend C.
Published: February 2024

Worldwide, comprehensive newborn screening (NBS) now includes a clinical examination at birth, hearing screening, pulse oximetry measurement for congenital heart defects, and biochemical screening to identify congenital disorders early in life, preventing irreversible damage, early mortality and enhancing overall health outcomes. This article provides a comprehensive overview of biochemical NBS in South Africa, outlining the history, current status, and future plans for NBS expansion. In South Africa, NBS is fragmented, with some investigations included in neonatal health assessments. Historically, biochemical NBS pilot projects in the country in the 1960s and 1980s focused on phenylketonuria and congenital hypothyroidism (CH). Despite showing initial promise, these programmes were discontinued, largely due to competing health priorities. The current status of biochemical NBS in South Africa is discussed, both for the state and private healthcare sectors, which collectively screen approximately 0.5% of births annually. While recent clinical guidelines provide for a national biochemical NBS programme, implementation has been limited, and guideline adherence remains a challenge. A brief report of a two-day meeting held in Cape Town in February 2023 focusing on biochemical NBS for South Africa is provided. The meeting addressed the importance of NBS, technology requirements, and the need for a comprehensive demonstration project for biochemical CH NBS. Key challenges identified included early newborn post-delivery discharge, technical, logistical, and infrastructure issues, as well as limited financial and human resources. Meeting recommendations included the establishment of a National Advisory Panel for Biochemical NBS, and the development and implementation of a demonstration project for CH biochemical NBS in two provinces.
Analysis of Socio-emotional Development in Mathematics Learning Through Multi-representative Based Test Instruments
Authors: Nisa Iftita Maharani Nisa Iftita Maharani
Published: February 2024

Artikel ini mengkaji perkembangan sosial emosional dalam pembelajaran matematika melalui tinjauan pustaka yang sistematis. Rumusan masalah dalam penelitian ini adalah sebagai berikut: Bagaimana perkembangan kesadaran sosial emosional dalam karya sastra? Bagaimana ciri-ciri sosial emosional siswa? Kesulitan apa saja yang mungkin dihadapi siswa dengan tingkat sosial emosional rendah ketika belajar matematika? konteks untuk mengamati perkembangan sosial-emosional siswa. Hasil penelitian ini menunjukkan bahwa perkembangan sosial emosional dalam sastra mencapai perkembangan sosial emosional siswa dalam pembelajaran, khususnya siswa menunjukkan sikap minat, partisipasi, dan komunikasi. Komunikasi, interaksi, kemampuan bekerja dalam kelompok dan mandiri. percaya diri, namun poin yang belum diraihnya adalah ketenangan, kesulitan beradaptasi, privasi dan kesulitan berkomunikasi dengan orang yang dianggapnya asing. Tercapainya perkembangan sosial emosional siswa di luar jam sekolah yaitu siswa menunjukkan rasa empati, peduli, suka membantu teman, tidak egois dan tahu cara mengendalikan emosi saat berinteraksi dan bersenang-senang, sedangkan yang belum tercapai hanya bermain-main dengan teman dekat. , kurang tercapai. Perhatikan apa yang terjadi di sekitar Anda, bicaralah hanya jika diperlukan, dan lebih memilih belajar daripada bermain.
Characterization of Mannanase-Producing Bacteria from Porang Tubers (Amorphophallus muelleri Blume)
Authors: Dwi Retnaningtyas Utami Dwi Retnaningtyas Utami
Published: February 2024

Porang tubers have the potential as a source of carbon and energy for the growth of mananolytic bacteria. Mananolytic are bacteria producing mananase enzymes that are able to break down manan compounds and their derivatives. Mananase can be widely applied in the food, pharmacy, animal feed sectors, paper industries and many more. In this study, Ai isolate have been isolated and characterized, porang tubers are used as substrates for measuring the activity of mananase. The optimum temperature mananase at 40 ° C, stable at a temperature of 30 ° C-50 ° C, have optimum pH 7 and are stable at pH 4-7. Fe2+ was an activator, while Ca2+ and Mg ions were inhibitor of mananase.
The Existence of Female Online Motorcycle Taxi Drivers as a Form of Gender Equality
Authors: Bashitq Basitha Ayu Savira
Published: February 2024

Emansipasi wanita adalah sebuah ruang kesetaraan. Dengan ini, perempuan mendapatkan kekuatan untuk menyetarakan kedudukannya dengan kaum laki-laki yang berhak memiliki kapasistas serta multi peran dalam kehidupan salah satunya adalah menjalan profesi yang dipilih oleh perempuan itu sendiri. Tujuan dari
penelitian ini adalah untuk melihat dan mengetahui efek dari eksistensi driver ojek online wanita sebagai bentuk kesetaraan gender. Penelitian ini menggunakan metode deskriptif dengan menggunakan metode wawancara dalam mengumpulkan datanya. Pada penelitian ini ditemukan bahwa eksistensi driver ojek online wanita bisa menjadi bentuk kesetaraan gender dilihat dari pola masyarakat yang berubah mengenai pengemudi wanita, namun diantara itu pula masih banyak masalah yang timbul yang dirasakan oleh pengemudi wanita yang dilakukan oleh pengemudi pria maupun customer. Penelitian ini terdapat keterbatasan dimana diantaranya adalah tidak banyak data pendukung yang bisa menunjang penelitian ini seperti jumlah pengemudi khususnya wanita serta data penunjang lain sehingga hasil penelitian ini hanya dari hasil wawancara dari pengemudi ojek online wanita yang ditemui dan teman-teman relasinya.
Kata Kunci: Driver wanita, Eksistensi Ojek Online Wanita, Kesetaraan Gender, Emansipasi Wanita, Feminitas
Disabilitas dan Relasi Sosial Keluarga dalam Film An Irish Goodbye: Analisis Semiotika Roland Barthes
Authors: Reza Reza Ulil Albab
Published: February 2024

An Irish Goodbye merupakan film yang mengangkat tema relasi sosial keluarga. Film yang meraih piala Oscar 2023 ini menceritakan pertemuan kembali Turlough dengan Lorcan, adiknya yang memiliki down syndrome, pada saat kematian ibu mereka. Dalam hal ini terjadi dinamika komunikasi antara Turlough dan Lorcan dalam menjalani hubungan keluarga. Penelitian ini bertujuan untuk memahami gambaran disabilitas dan dinamika relasi sosial dalam keluarga yang terbentuk antara Turlough dan Lorcan menggunakan analisis semiotika Roland Barthes yang melibatkan tiga tahap: denotasi, konotasi, dan mitos, untuk mengungkap makna dari tanda yang terdapat dalam adegan. Pendekatan kualitatif deskriptif dipilih dengan pengumpulan data melalui observasi adegan, dokumentasi tangkapan layar, dan studi pustaka dari berbagai referensi. Hasil penelitian, ditemukan 13 scene yang menggambarkan tiga temuan. Pertama, stereotipe terhadap disabilitas yang dialami oleh Lorcan digambarkan dengan Turlough yang melihat adiknya sebagai individu yang lemah dan tidak mempunyai logika sehingga ia mengabaikannya. Kedua, relasi keluarga dan kedekatan emosional yang terbentuk antara Turlough dan Lorcan memiliki jarak yang menciptakan konflik serta dinamika dalam relasi mereka. Ketiga, bonding antara saudara yang digambarkan melalui usaha Lorcan untuk memperkuat ikatan emosionalnya dengan Turlough, yang akhirnya menjadi lebih kuat ketika Turlough memahami dan mempercayai Lorcan. Turlough mengabaikan Lorcan karena kondisinya dan menciptakan jarak emosional dalam relasi mereka, keberhasilan upaya Lorcan, memperkuat kembali ikatan mereka dan menciptakan dinamika dalam relasi yang positif.
Lifestyle Construction in Coffee Shops in Malang City from the Perspective of Symbolic Violence
Authors: Marlina Baiq Nana
Published: February 2024

The coffee shop industry is experiencing rapid growth as coffee consumption increases in Indonesia. The focus of this research is Malang City, which is the center of coffee shop growth in Indonesia. Through a cultural studies paradigm approach, this research aims to understand the construction process of coffee consumer lifestyles in Malang City. This phenomenon marks a shift in consumer behavior from necessity to a sub-culture where coffee shops are not only a gathering place, but also a symbol of self-identity and an urban lifestyle. The research used visual methods with 6 participants from two different coffee shops. The data collection process focused on coffee shops, interior design, consumers, and visual elements that influence lifestyle. The concept of Pierre Bourdieu's social praxis theory is used as an analytical framework to understand the construction of lifestyle and the role of symbolic power. The research results show that the existence of coffee shops influences culture and lifestyle in Malang City. Starbucks, as the main agent, shapes the values and standards adopted by local coffee shops such as Amstirdam. Patterns of symbolic violence emerge in consumer clothing standards, depicting coffee shops not only as places to buy and sell coffee, but also as public spaces that shape identity and social norms. This research contributes to a deeper understanding of the role of coffee shops in shaping lifestyle and culture in society.
The Structural Equation Modelling of First Level Health Facilities’ Performance-Based Capitation Payment in National Health Service
Authors: Aryani Ari Dwi , Bachtiar Adang , Candi Cicilya
Published: February 2024

The BPJS Healthcare Security implemented performance-based capitation/Kapitasi Berbasis Kinerja(KBK) payments to conduct structured and ongoingmonitoring of the First Level Health Facilities/Fasilitas Kesehatan Tingkat Pertama(FKTP)'s performance throughout Indonesia. This study aimed to examinethe direct and indirect effects of FKTP capacity on KBK and FKTP performance. This study was conducted in February 2023, and Structural EquationModelling analysis was performed with secondary data from the BPJS Healthcare Security system database in 2021. Human resources were defined as theavailability of doctors in FKTP, infrastructure as credentialing value, ownership and type of FKTP, and KBK, and performance as first contact, non-specialistoutpatient referral ratios, and Chronic Disease Management Program/Program Pengelolaan Penyakit Kronis(Prolanis) participant ratio. The analytical resultsrevealed that human resources directly and positively affected the KBK. The indirect effect analysis results suggested that only human resources impactedFKTP performance. In conclusion, human resources are critical in achieving the KBK and FKTP performance.
The Importance of Blood Pressure Control in the Survival of Peritoneal Dialysis Patients Using a Multistate Model
Authors: Najafimehr Hadis , Rahimi Foroushani Abbas , Yekaninejad Mir Saeed , Yousefifard Mahmoud , Hosseini Mostafa
Published: February 2024

Since less attention has been paid to the effect of passing blood pressure states on the survival of peritoneal dialysis (PD) patients, this study aimed to inves­tigate the survival of PD patients with and without hypertension, estimate the probability of hypertension and determine the influential factors. In this retro­spective cohort study, the data of 700 patients visiting dialysis centers from all provinces of Iran from 1997-2009 were analyzed. For data analysis, the multistate survival model was used. The median survival time (months) and five-year survival were 75% and 56%, respectively. Males had a higher probability of hypertension (63%) than females (52%). The risk of death in normotensive patients increased with age and fast blood sugar (FBS) (age: HR = 1.02, p-va­lue <0.001; FBS: HR = 1.03, p-value = 0.034) and decreased with increasing albumin (HR = 0.60, p-value = 0.015). When experiencing hypertension, the death risk increased with age (age: HR = 1.03, p-value<0.001); also, higher serum albumin and blood urea nitrogen (BUN) had a protective effect against mortality (albumin: HR = 0.66, p-value = 0.038; BUN: HR = 0.99, p-value = 0.014). Paying attention to age, obesity, and blood sugar in PD patients seems necessary.
WITHDRAWN: Dark Current in Pinned Photodiode CMOS Image Sensors: A Pre-Fabrication Physics-based Model
Authors: Suharwerdi Mohsin , Qazi Gausia
Published: February 2024

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
A strategic optimizing carbon neutrality within profit and emission reduction efficiency: A Stackelberg game analysis under a cap-and-trade scheme
Authors: Hussain Jafar , Lee Chien-Chiang , Ren Jifan
Published: February 2024

Carbon emissions (CO2e) are a main problem, and many countries are committed to reducing CO2e to attain carbon neutrality. To narrow this gap, this research considers green technology implementation (GTI) and CO2e quota in dual green gaming. The objective is to explore the integration of GTI and CO2e quotas into optimal production and pricing decisions in emission-generating companies (EGCs). To achieve this, a two-party simulation Stackelberg game model involving the CO2e strategy of EGCs and governments is proposed. We formulate a mathematical model and experimental methods to optimize EGCs' decision-making using neutral indicators. EGCs optimize production quantity, achieving CO2e reduction through ERE maximization. EGCs exhibit a strong commitment to ERE enhancement practices, enhancing profit and carbon-neutral goals. Our findings demonstrate the effectiveness of CO2e quotas and GTI as carbon-neutral indicators in EGCs, contributing to global carbon emission reduction. Our research provides both literature and inspiration for global CO2e reduction efforts. Moreover, it aids governments in exploring optimal incentives and decisions for pricing and production. Last, this work enables EGCs to maximize profits and move toward a carbon-neutral environment.
Genomic heterogeneity of Multidrug Resistance E.coli recovered from diarrheagenic children under five years from Mukuru Informal Settlement, Nairobi, Kenya
Authors: Kiiru Susan , Kasiano Purity , Maina John , Mwaniki John Njeru , Songoro Edinah , Kariuki Samuel
Published: February 2024

Introduction High genomic plasticity within E. coli enables it to acquire and accumulate genetic material through horizontal gene transfer like mobile genetic elements. In this study, we sought to investigate the virulence genes, phylogroups, antibiotic resistance genes( ARGs), plasmid replicons, MLST, and cgMLST of multidrug-resistant E.coli recovered from diarrheagenic children under five years from Mukuru Informal Settlement, Nairobi Kenya.
Methods A total of 39 MDR strains had their DNA extracted, and Whole Genome Sequencing was done using the Illumina HiSeq 2500 platform. Twenty-six E.coliassemblies were analyzed using web-based bioinformatics tools available at the Centre for Genomic Epidemiology (TDU) and EnteroBase.
Results The isolates fell into 4 main phylogroups, where 10/26(38.5%) belonged to the B2 phylogroup, 4/26 ( 15.4%) belonged to D, 3/26( 11.5%) belonged to A, 1/26( 3.8%) belonged to B1, while 8/26 ( 30.8%) were not determined. FimH30 was predominantly found in the most frequent phylogroup B2 and Sequence Type(ST) 131. A total of 40 diverse virulence genes were detected among the isolates. 13 different STs were isolated from the E. coli genomes, which included ST 131, ST 3036, ST 38, ST 10, ST 12569, ST 15271, ST 2076, ST 311, ST 3572, ST 394, ST 453, ST 46 and ST 1722. Only two isolates ( 2/26, 7.7%) from the Municipal City Council ( MCC) clinic were genetically related. Additionally, the most abundant plasmid replicon identified belonged to the IncF family, IncFII(pRSB107) in particular, followed by the Col family. Of 26 isolates, 15 had at least one nonsynonymous mutation in the housekeeping genes gyrA (p.S83L), gyrA (p.D87N), parC (p.S80I), parC (p.E84V), parC(p.S57T), and parE(p.I529L),associated with resistance to fluoroquinolones.
Conclusion The study highlighted the first E.coli ST46 to harbor the NDM5 gene encoded in Col(BS512), IncFII(pRSB107), and IncFIB(AP001918) plasmid replicons in Kenya. We further demonstrated the diversity of MDR E. coli associated with diarrhea in an endemic setting in Kenya.
Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice
Authors: Ananth Mala R. , Gardus John D. , Huang Chuan , Palekar Nikhil , Slifstein Mark , Zaborszky Laszlo , Parsey Ramin V. , Talmage David A. , DeLorenzo Christine , Role Lorna W.
Published: February 2024

In a series of translational experiments using fully quantitative positron emission tomography (PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([18F]VAT) in vivo in humans, and genetically targeted cholinergic markers in mice, we evaluated whether changes to the cholinergic system were an early feature of age-related cognitive decline. We found that deficits in cholinergic innervation of the entorhinal cortex (EC) and decline in performance on behavioral tasks engaging the EC are, strikingly, early features of the aging process. In human studies, we recruited older adult volunteers that were physically healthy and without prior clinical diagnosis of cognitive impairment. Using [18F]VAT PET imaging, we demonstrate that there is measurable loss of cholinergic inputs to the EC that can serve as an early signature of decline in EC cognitive performance. These deficits are specific to the cholinergic circuit between the medial septum and vertical limb of the diagonal band (MS/vDB; CH1/2) to the EC. Using diffusion imaging, we further demonstrate impaired structural connectivity in the tracts between the MS/vDB and EC in older adults with mild cognitive impairment. Experiments in mouse, designed to parallel and extend upon the human studies, used high resolution imaging to evaluate cholinergic terminal density and immediate early gene (IEG) activity of EC neurons in healthy aging mice and in mice with genetic susceptibility to accelerated accumulation amyloid beta plaques and hyperphosphorylated mouse tau. Across species and aging conditions, we find that the integrity of cholinergic projections to the EC directly correlates with the extent of EC activation and with performance on EC-related object recognition memory tasks. Silencing EC-projecting cholinergic neurons in young, healthy mice during the object-location memory task impairs object recognition performance, mimicking aging. Taken together we identify a role for acetylcholine in normal EC function and establish loss of cholinergic input to the EC as an early, conserved feature of age-related cognitive decline in both humans and rodents.
Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD
Authors: Leno Virginia Carter , Begum-Ali Jannath , Goodwin Amy , Mason Luke , Pasco Greg , Narvekar Nisha , Pickles Andrew , Charman Tony , Johnson Mark , Jones Emily , Team The STAARS
Published: February 2024

Autism and ADHD are characterised by atypical sensory responsivity, and this may be driven by alterations in the balance of cortical excitation to inhibition (E/I). Studies in early development are required to establish the primary of effects. We utilised data from a prospective longitudinal cohort of infants with and without a family history (FH) of autism and/or ADHD (N=151; 55% male, 83% white). We extracted electroencephalography (EEG) metrics of E/I balance at 5, 10 and 14 months; the aperiodic exponent of the slope of the power spectrum (‘1/f’). Models estimated correlated latent growth curves of parent-reported hyper and hypo-responsivity between 10 – 36 months. Analyses tested associations between developmental trajectories of sensory responsivity and FH, parent-rated neurodevelopmental traits at 3 years and E/I balance. Results showed that FH-autism was associated with steeper increases in parent-reported hyper-responsivity between 10 to 36 months, whereas FH-ADHD was associated with steeper increases in hypo-responsivity. Higher hypo-responsivity at 10-month baseline was associated with both autistic and ADHD traits at 3 years. A steeper slope of hypo-responsivity predicted ADHD traits at 3 years. Neither the baseline or slope of hyper-responsivity was associated with FH-ADHD, or autistic or ADHD traits at 3 years. Males displayed higher baseline hypo-responsivity. Aperiodic exponent values at 5 and 10, but not 14 months, were associated with hyper-responsivity. Results suggest that hypo-responsivity in infancy may be an indicator of later autism and ADHD outcomes. Alterations in E/I balance may contribute to early differences in sensory responsivity and thus could represent a useful target for intervention development.
Subcellular functions of tau mediates repair response and synaptic homeostasis in injury
Authors: Grosshans David , Thomas Riya , Zhang Die , Cronkite Christopher , Thomas Rintu , Singh Sanjay , Bronk Lawrence , Morales Rodrigo , Duman Joseph
Published: February 2024

Injury responses in terminally differentiated cells such as neurons is tightly regulated by pathways aiding homeostatic maintenance. Cancer patients subjected to neuronal injury in brain radiation experience cognitive declines similar to those seen in primary neurodegenerative diseases. Numerous studies have investigated the effect of radiation in proliferating cells of the brain, yet the impact in differentiated, post-mitotic neurons, especially the structural and functional alterations remain largely elusive. We identified that microtubule-associated tau is a critical player in neuronal injury response via compartmentalized functions in both repair-centric and synaptic regulatory pathways. Ionizing radiation-induced injury acutely induces increase in phosphorylated tau in the nucleus and directly interacts with histone 2AX (H2AX), a DNA damage repair (DDR) marker. Loss of tau significantly reduced H2AX after irradiation, indicating that tau may play an important role in neuronal DDR response. We also observed that loss of tau increases eukaryotic elongation factor levels after irradiation, the latter being a positive regulator of protein translation. This cascades into a significant increase in synaptic proteins, resulting in disrupted homeostasis. Consequently, novel object recognition test showed decrease in learning and memory in tau-knockout mice after irradiation, and electroencephalographic activity showed increase in delta and theta band oscillations, often seen in dementia patients. Our findings demonstrate tau’s previously undefined, multifunctional role in acute responses to injury, ranging from DDR response in the nucleus to synaptic function within a neuron. Such knowledge is vital to develop therapeutic strategies targeting neuronal injury in cognitive decline for at risk and vulnerable populations.
Predictors of disability trajectories in individuals with spinal cord injury in mainland China
Authors: li lunlan , huang hui , feng linsheng , ding peipei , xia xiaoxiao , Dai Qing
Published: February 2024

Study Design: Observational cohort study.
Objectives: To identify classes of disability trajectories from spinal-cord injury to 6 months after discharge and to investigate whether psychosocial resources and disease factors can predict disability trajectory.
Setting: Spinal surgery in three Class III hospitals. Hospitals in China are divided into three classes (Class I, II and III). Class III hospitals are the highest-level hospitals in China.
Methods: All the participants were submitted to WHO Disability Assessment Schedule (WHO-DAS 2.0) at three times；and personal data anamnesis, hope, PTSD, social support
were recorded at first time. All the data collected by the master's students who participated in this study.
Results: Two disability trajectories were identified using the latent class growth model: the continuous high disability group (N=196, 93.3%) and the low starting point stabilization group (N=14, 6.7%). Participants with higher American Spinal Injury Association (ASIA) (β=1.26; 95% confidence interval [CI] 1.00-12.21) and more depression (β=0.249; 95% CI 1.05-1.56) in the stable condition after SCI surgery were more likely to be classified as having higher disability than those with a lower disability
trajectory. Occupation, annual family income, hope, social support, and Post-traumatic Stress Disorder (PTSD) cannot predict individuals belonging to trajectory classes.
Conclusion: These findings emphasize the importance of ASIA and depression in the early recovery stage after SCI and support the opinion that strengthening psychological nursing and rehabilitation management at an early stage after SCI will benefit individuals with a lower disability trajectory.
Trans-Ancestry Analysis of Psychosis Biotypes: Shared Polygenic Risk and Unique Genomic Associations
Authors: Gershon Elliot , Xia Cuihua , Alliey-Rodriguez Ney , Tamminga Carol , Keshavan Matcheri , Pearlson Godfrey , Keedy Sarah , Parker David , Lencer Rebekka , Hill Scot , Bishop Jeffrey , Gandal Michael , Wen Cindy , Dai Rujia , Chen Chao , Liu Chunyu
Published: February 2024

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) has categorized psychosis disorders (Schizophrenia, Schizoaffective Disorder and Bipolar Disorder) into three distinct Biotypes, based on neurobiological measurements in a multi-ancestry sample. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Trans-Ancestry PRSs (TAPRSs), which allow for PRS analysis of multi-ancestry samples. Applied to schizophrenia PRS, we found the Khera TAPRS method to show superior portability and comparable prediction accuracy as compared with the Ge method. The three Biotypes of psychosis disorders had similar TAPRSs across ancestries. In genomic analysis of Biotypes, nine genes and isoforms showed significant genomic associations with Biotypes in Transcriptome-Wide Association Study (TWAS) of gene expression in adult brain and fetal brain, and of gene isoforms. TWAS inflation was successfully controlled by inclusion of genotype Principal Components in the association analyses. Biotypes and Biotype-related diagnosis distributions differ between African American and European ancestries.
Laparoscopic debulking plus HIPEC for gastric cancer in Colombia: Our first case
Authors: Rojas-Sierra Juliana , Moreno-Salamanca maria andrea , Vivero Alvaro Restrepo-de , Flórez-Castro Juan Pablo
Published: February 2024

Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy via a moderately invasive technique is a procedure used for treating colon and ovarian neoplasms, and this approach has widely documented benefits in this area. However, in patients with gastric adenocarcinoma, the potential benefit of this approach has not been fully demonstrated, and little evidence is available. This report describes a patient with gastric cancer who underwent cytoreduction and HIPEC and the perioperative management of this patient, with emphasis on the intraoperative course from an anesthetic point of view and the immediate and early postoperative follow-up. This type of report will generate knowledge documenting behaviors and outcomes in this particular population that can potentially benefit from this therapy.
The Effect of Health Belief Model-Based Training on the Self-Compassion and Self-Efficacy of Premenopausal Women
Authors: Rezaei Elham , Maqsoud Zeinab Mirzaei , Moghadam Zahra Behboudi
Published: February 2024

Introduction: The premenopausal period causes many mental and physical problems in women due to hormonal changes. Education can be effective in adapting to this transitional period. This study aimed to assess the effect of health belief model-based training on the self-compassion and self-efficacy of premenopausal women.
Method: This randomized clinical trialincluded 90 Iranian women (45 intervention and 45 control) in their premenopausal period (40-50 years old), referred to comprehensive health centers in 2021. The intervention group was trained in four sessions using Skype software based on dimensions of the health belief model. The primary and key secondary outcomes were self-efficacy and self-compassion, which were assessed using questionnaires three times: before, immediately, and one month after intervention. The data were analyzed with SPSS 27 using the ITT method.
Result: The results showed that most women in each group were aged 45-50. According to the results, immediately and one month after the intervention, self-efficacy (MD(SDD):43.91(0.83);P<0.001), self-compassion(MD (SDD):59.46(0.83) ;P<0.001), or the total score of the health belief model (MD (SDD):58.12(0.81) ;P<0.001)were significantly different between the two groups .
Conclusion: This study showed that the level of self-efficacy and self-compassion of premenopausal women increased after education based on the health belief model.
Association between Stress Hyperglycemia Ratio and Functional Outcomes in Patients with Acute Ischemic Stroke
Authors: Xiao Shiyan , Gao Maofeng , Hu Shoudi , Cao Simin , Teng Liting , Xie Xiaohua
Published: February 2024

Objective: This study aimed to evaluate the association between stress hyperglycemia ratio (SHR) and poor functional outcomes at 90 days in patients with acute ischemic stroke (AIS).
Methods: Retrospective collection of 1988 patients with AIS admitted to two hospitals in the Shenzhen area between January 2022 and March 2023. A total of 1255 patients with Fasting Blood-glucose (FBG) and hemoglobin A1c (HbA1C) values at admission were included in this analysis. SHR, measured by FBG/HbA1C, was evaluated as both a tri-categorical variable (Tertile 1: ≤0.83; Tertile 2: 0.84 -0.95; Tertile 3: ≥0.96). The outcome was poor functional outcomes (modified Rankin Scale [mRS] score 2-6) at 90 days. We performed univariate analysis, multiple equation regression analysis, stratified analysis, and interactive analysis.
Results: Compared with patients in the lowest tertile of SHR, the highest tertile group had significantly lower odds of achieving poor functional outcomes (adjusted odds ratio, OR=2.84, 95% CI: 2.02-3.99, P<0.0001) at 90 days after adjusting for potential covariates. Similar results were observed after further adjustment for white blood cell count, neutrophil count, lymphocyte count, fasting blood glucose, stroke type, intravenous thrombolytic therapy, baseline Glasgow score, and baseline NIHSS score.
Conclusion: Stress hyperglycemia ratio, as measured by the FBG/HbA1C, was associated with an increased odds of achieving poor functional outcomes in patients with AIS at 90 days.