bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Annexins Family as Potential Biomarker for Predicting Progression and Prognosis in Clear Renal Cell Carcinoma
Authors: Zhao Jiyu , Chang Luchen , Tu Jianping , Sun Bei , Wei Xi
Published: August 2021

Background: Annexins family (ANXAs), as a Ca2+-dependent, phospholipid-binding protein super family, participated in a wide variety of biological activities and has been reported to be dysregulated in numerous types of human cancers. Evidence from cell lines and human tissues indicates that ANAXs are involved in kidney clear renal cell carcinoma (KIRC) tumorigenesis. However, their prognostic value and expression pattern associated with KIRC remain to be elucidated. Methods: We visited public databases including ONCOMINE, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioportal and GeneMANIA to conduct comprehensive bioinformatics analysis, and tried to detect basic relationships between each Annexins family member and KIRC. Results: In the present study, we found that the expression level of ANXA1/2/4/5/6/7/8/13 in clear renal cell carcinoma tissue was higher than that in kidney tissue, while the expression level of ANXA3/9/11 in the former was lower than that in the latter. The expression level of ANXA7/8/13 is related to the stage of the tumor. Survival analysis using the Kaplan-Meier plotter database showed that the high transcription level of ANXA2/5/8/10 is related to the low overall survival rate (OS) in predicting KIRC patients. In contrast, high ANXA3/4/7/9/11/13 levels are associated with high OS in these patients.Conclusions: Our study implies that ANXA4/8/13 are potential targets of precision therapy for patients with KIRC and that ANXA2/5/8/10 are new biomarkers for the prognosis of KIRC.
Synthesis, Tribological Properties and Mechanism of Nickel Nanoparticles as Additives in Lithium Grease
Authors: Zhang Hong , hu wenjing , Li Jiusheng , Han sheng
Published: August 2021

The advanced nano-additives can effectively improve the tribological properties of grease, which can greatly reduce friction consumption. Therefore, we prepared nickel nanoparticles by direct reduction method using Ni(HCOO)2 • 2H2O as the basic raw material. The morphology and structure of the nanoparticles were characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), FT-IR spectrometer (FT-IR) and thermal gravimetric analysis (TGA). In order to investigate the lubrication performance of nickel nanoparticles in lithium grease, friction experiments were carried out on four-ball friction tester and TE77 ball-on-plate reciprocating model. Then, the worn surfaces were analyzed by scanning electron microscope and white light interferometry. Meanwhile, the element composition and valence state on friction surfaces were detected by energy dispersive spectrometer and X-ray photoelectron spectroscopy. Based on the experimental results, it was concluded that the nickel nanoparticles can effective improved the tribological properties by interlayer sliding. Moreover, the nickel nanoparticles could promote the formation of friction film on boundary lubrication surface and chemical reaction film between friction pairs. This study could provide a new direction for metal nano-additives to improve the tribological properties of grease.
Identification of Potential Biomarkers and Therapy Targets involved in Gastric Cancer Using Bioinformatics Analysis
Authors: Teng YangYang , Shan Na , Lu GuangRong , Ni LeYi , Gao ZeJun , Shen Yao , Xu Sheng , Wang QinJian , Ying QingJi , Zhang Jing , Yu HeJie , Xue ZhanXiong , Xing Chao , Cai ZhenZhai
Published: August 2021

Gastric cancer remains one of the five major malignant tumors in the world, posing a great threat to public life and health. As gene sequencing technology develops, it is urgent to find out specific molecular markers for cancer therapy. In this study, datasets of GSE13911, GSE30727, GSE63089 and GSE118916 were investigated by bioinformatics analysis, and differentially expressed genes (DEGs) between GC tissues and normal tissues were screened for potential cancer therapeutic targets. Furthermore, the GSE63089 dataset was analyzed by Weighted Gene Co-expression Network Analysis (WGCNA), and the highly related genes were clustered. Then, the hub genes were searched using co-expression network and Molecular Complex Detection (MCODE) plug-in from Cytoscape software. Finally, ASPM, COL11A1 and CDC20 were obtained by intersection of hub genes and DEGs. The expressions of ASPM, COL11A1 and CDC20 gene in gastric cancer tissues and normal tissues from TCGA database were detected. For these genes, the least absolute shrink and selection operator (LASSO) Cox expression analysis was used to establish the prognostic risk model. COL11A1 and CDC20 genes were identified as candidate prognostic risk markers for GC. Analysis using qRT-PCR has shown that COL11A1 and CDC20 were significant differentially expressed between gastric cancer tissues and normal gastric tissues (P < 0.01). In conclusion, our study identifies specific DEGs involved in ECM process and metabolism by cytochrome P450 process, and these DEGs may be potential targets for GC therapy. The model constructed by COL11A1 and CDC20 genes can predict the prognosis risk of GC patients. Taken together, these findings provide reference for further analyses of key alterations during GC progression.
Accuracy and Influencing factors of Pulmonary Artery Systolic Pressure estimated by Doppler Echocardiography: Comparsion with Right Heart Catheterization
Authors: Lv Guangjie , Li Aili , Tao Xincao , Zhai Yanan , Zhang Yu , Lei Jieping , Gao Qian , Xie Wanmu , Zhai Zhenguo
Published: August 2021

Purpose

This study aimed to explore the accuracy and influencing factors of noninvasive assessment of pulmonary artery systolic pressure by Doppler echocardiography (sPAPECHO) with right heart catheterization (RHC) as reference.
Methods

A total of 218 highly suspected pulmonary hypertension (PH) patients who underwent RHC and echocardiography within 7 days were included. The ratio of (sPAPECHO-sPAPRHC)/sPAPRHC was calculated and divided into three groups, namely, the underestimation group, accurate group and overestimation group by ± 10% as the boundary. The correlation and consistency between tricuspid regurgitation (TR) derived parameters and RHC results were tested by Pearson and Bland-Altaman methods. With mPAP ≥ 25mmHg measured by RHC as the standard diagnostic criteria of PH, ROC curve was used to evaluate the diagnostic efficacy. The influencing factors of sPAPECHO were analyzed by ordered regression analysis.
Results

sPAPECHO had the greatest correlation coefficient (r = 0.781, P < 0.001) and best diagnostic efficiency (AUC = 0.98) compared with other TR related methods. Bland-Altman analysis demonstrated the bias of sPAPECHO (mean bias = 0.07mmHg, 95% limits of agreement: -32.08 to + 32.22mmHg) was lower than that of TR-PG (mean bias = 5.87mmHg, 95% limits of agreement: -26.46 to + 38.21mmHg). The results of ordered regression analysis showed that TR signal quality, PAWP and sPAPRHC level affected the accuracy of sPAPECHO (P < 0.05). Relative to the signal quality of type A, the OR value of type B and C signal quality were 0.26 (95%CI: 0.14, 0.48) and 0.23 (95%CI: 0.07, 0.73), respectively. The OR value of PAWP was 0.94 (95%CI: 0.89, 0.99). Compared with high sPAPRHC level, the OR value of low and medium sPAPRHC level were 21.56 (95%CI: 9.57, 48.55) and 5.13 (95%CI: 2.55, 10.32), respectively.
Conclusion

sPAPECHO was superior than other TR-related methods in screening PH. TR signal quality is vital for accurate assessment of sPAPECHO. For patients with pre-capillary disease, a higher echocardiographic threshold is more suitable for determining the possibility of PH, especially during the initial stage of disease.
An Extended DMPs framework for Decoupled Quaternions Learning and generalization
Authors: Liao Zhiwei , Zhao Fei , Jiang Gedong , Mei Xuesong
Published: August 2021

Dynamic Movement Primitives (DMPs) as a robust and efficient framework has been studied widely for robot learning from demonstration. Classical DMPs framework mainly focuses on the movement learning in Cartesian or joint space, and can't properly represent end-effector orientation. In this paper, we present an Extended DMPs framework (EDMPs) both in Cartesian space and Riemannian manifolds for Quaternion-based orientations learning and generalization. Gaussian Mixture Model and Gaussian Mixture Regression are adopted as the initialization phase of EDMPs to handle multi-demonstrations and obtain their mean and covariance. Additionally, some evaluation indicators including reachability and similarity are defined to characterize the learning and generalization abilities of EDMPs. Finally, the quaternion-based orientations are successfully transferred from human to the robot, and a real-world experiment is conducted to verify the effectiveness of the proposed method. The experimental results reveal that the presented approach can learn and generalize multi-space parameters under multi-demonstrations.
Multifunctional PD-L1 Targeted Fe3O4@DOX Nanoparticles Under MRI Monitoring For Combination Therapy of Triple-Negative Breast Cancer
Authors: Zhao Jie , Li Ming , Duan Jiazhi , Guo Hang , Yu Dexin
Published: August 2021

Background: The triple negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat, with currently restricted treatment of chemotherapy. However, evidence suggests that immunomotropy is only effective for a small portion of patients. The combination therapy of both immunotherapy and chemotherapy has demonstrated great promise in its treatment efficiency. However, this combination therapy is limited by both the organ toxicity of the chemotherapeutic drugs and the inaccessibility of the in vivo monitoring of individual tumor response to therapies. With the development of the nanomedicine, synchronous targeting therapy, imaging diagnosis and monitoring can be achieved convenientlly using the multifunctional nano-platform for TNBC. Results: In our study, we prepared the DOX loaded Fe3O4 nanoparticles targeting the PD-L1 (PD-L1@Fe3O4-DOX, FPD) to obtain the real-time magnetic resonance imaging (MRI) monitoring and combination therapy of both chemotherapy and immunotherapy for TNBC. The results showed that FPD inhibited tumor growth more effectively than either DOX chemotherapy or PD-L1 immunotherapy alone. Conclusion: Our study demonstrated that FPD has shown a great potential for theranostics and clinical translation in synchronous MRI imaging-guided monitoring and combined treatment of both DOX and immunotherapy of TNBC.
Prognostic Biomarker SYK and its Correlation with Immune Infiltrates in Glioma
Authors: Liu Pei , Guo Jiamin , Xu Xiaoxiao , Sun Haixin , Gong Zheng
Published: August 2021

Background: Tumor microenvironment (TME) has great effects on the development process of glioma, and we sought to identify effective prognostic factors by analyzing data from patients with glioma. In this paper, CIBERSORT and ESTIMATE calculations were employed to figure up the ratio of tumor-infiltrating immune cells (TICs) and the quantity of immune and stromal components in 698 glioma dates from The Cancer Genome Atlas (TCGA) database. In addition, differentially expressed genes (DEGs) were studied by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and single genes associated with prognosis were identified by PPI network and COX combined analysis. Results: Immune and stromal scores of TME were significantly correlated with glioma patient survival. Through protein–protein interaction (PPI) network and regression analysis of COX, we finally determined that SYK was the best prognostic factor for patients with glioma. Gene Set Enrichment Analysis (GSEA) and CIBERSORT analysis were also employed, with the former showed that high-expression SYK group’s genes are principally enriched immune-related activities and the latter revealed that SYK expression was positively associated with T cells CD4 memory resting and Monocytes. All the above experimental analyses provided the theoretical basis for the biological prediction of SYK.Conclusions: SYK contributes to immune predictors in glioma patients by facilitating the shift of TME from immune dominance to metabolic activity, which provides promising insights into the treatment of glioma.
Positional Relationship Between Lacrimal Sac and Skull Base: Implication of Risk of Cerebrospinal Fluid Leakage During Dacryocystorhinostomy
Authors: Kono Shinjiro , Vaidya Aric , Naito Munekazu , Nakano Takashi , Ito Makoto , Kakizaki Hirohiko , Takahashi Yasuhiro
Published: August 2021

Cerebrospinal fluid (CSF) leakage is a rare but severe complication during dacryocystorhinostomy (DCR). Understanding the details of the anatomy of the lacrimal drainage system and skull base is essential to avoid this complication. We examined the positional relationship between the lacrimal sac and skull base using 16 cadavers (22 sides) and computed tomographic images taken in 81 patients (81 sides). Consequently, the frontal sinus intervened between the lacrimal sac and skull base in 81.8–90.1% of cases. The lacrimal sac fundus and posterior lacrimal crest were far from the skull base/cribriform plate, and the skull base above the lacrimal sac was considerably thick. These results indicate that the risk of skull base injury and following CSF leakage during DCR is extremely low. However, surgeons should be cautious of this complication by indirect injury due to a twisting movement of a bone rongeur applied to the maxillary bone during the creation of a bony window in patients with no interposition of the frontal and ethmoid sinuses between the lacrimal sac and skull base.
PMN-PSMNT ceramics fabricated using the twin-crystal mixed co-firing method
Authors: Bao Guocui , Shi Dongliang , Li Kun , Yang Guang , Fang Bijun , Lam Kwok-ho
Published: August 2021

(1-w)[Pb(Mg1/3Nb2/3)0.67Ti0.33O3]-w[Pb1 − 1.5xSmx(Mg1/3Nb2/3)yTi1−yO3] ((1-w)PMN-wPSMN-PT) piezoelectric ceramics were prepared using the newly proposed twin-crystal mixed co-firing method in which two pre-sintered precursor powders were mixed and co-fired with designated ratios (w = 0.3, 0.4, 0.5, 0.6). X-ray diffraction results show that all the samples presented a pure perovskite structure. The grains were closely packed and the average size was ~ 5.18 µm from the observations of scanning electron microscopy images, giving the high density of ceramics to be 97.8% of the theoretical one. The piezoelectric, dielectric, and ferroelectric properties of the ceramic samples have been investigated systematically. It was found that the performance of ceramics was significantly enhanced when compared to the ceramics fabricated using the conventional one-step approach. Outstanding piezoelectric coefficient d33 of 1103 pC/N and relative dielectric permittivity εr of 9154 could be achieved for the ceramics with w = 0.5.
Prediction of the Risk of Preoperative Deep Vein Thrombosis in Non-fractured Patients Awaiting Total Joint Arthroplasty Using a Support Vector Machine
Authors: Wang Haosheng , Fan Tingting , Chen Yanhua , Li Wenle , Zhao Fujiang , Liu Qiuming , Yang Mingyu
Published: August 2021

Background: We developed a potential useful alternative prediction model based on the support vector machine (SAM) algorithm to predict the risk of preoperative deep vein thrombosis (DVT) in non-fractured patients awaiting total joint arthroplasty (TJA). Methods: From March 2015 to August 2020, a retrospective review of the preoperative ultrasound examination findings of lower extremity venous vessels was performed on non-fractured patients of 369 elective TJA. Based on the ultrasound examination findings of preoperative lower extremely venous vessels, these patients were divided into two groups: the DVT group and the Non-DVT group. We collected the clinical, imaging, and laboratory findings from an electronic medical record system. These variables were imported into univariate, multivariate and logistic regression analysis to identify the risk factor for preoperative DVT. According to published literature and clinical experience, a series of variables were selected to construct a prediction model based on the SVM machine learning algorithm. Results: Among the 369 patients, preoperative DVT was observed in 21 patients (5.7%). The Multivariate regression analysis showed the following 5 independent factors associated with preoperative DVT: preoperative fibrinogen odds ratio [OR] = 7.306), age (OR = 1.133), history of hypertension (OR = 3.848), preoperative hematocrit (OR = 0.315), and D-dimer (OR = 2.032). The SVM model achieved a maximum and average area under the receiver operating characteristic curve (AUC) of 0.94 and 0.77 in the 10-fold cross-validation. Meanwhile, the accuracy, precision, and recall of the model were 0.98, 0.92, and 0.93, respectively. Additionally, the confusion matrix showed the classification results of the discriminant analysis.Conclusions: SVM machine modeling is a promising method for the prediction of the risk of DVT in non-fractured patients awaiting TJA. However, future external validation is needed.
Liraglutide improves cognitive function by reducing amyloid-beta peptide accumulation and inhibiting inflammation in 5×FAD mice
Authors: Qi Liqin , Lin Lijing , Zheng Jiaping , Liu Xiaoying , Liu Xiaohong , Chen Zhou , Liu Libin
Published: August 2021

The glucagon-like peptide-1 analog, liraglutide, has been shown to be effective in Alzheimer’s disease (AD); however, the underlying mechanism remains unknown. In this study, we evaluated the effects of liraglutide (25 nmol/day for 8 weeks) on the cognitive ability of 12-month-old 5× familial Alzheimer’s disease (FAD) mice. The spatial cognitive ability was improved in 5×FAD mice after administration of liraglutide, associated with an increased number of pyramidal cells in the cortex and hippocampus. Liraglutide also alleviated the ultrastructural changes in chemical synapses and pyramidal cells and reduced local and universal inflammation in AD mice. Furthermore, liraglutide reduced the expression of amyloid β protein through the regulation of nuclear factor kappa B/beta-secretase 1 pathways in AD mice. The potential of liraglutide to improve the cognitive function in AD animals offers an effective pharmacological approach for treating neurodegenerative diseases.
Challenges in the Management of Malignant Adenomioepithelioma of the Breast: a Case Report and Review of the Literatures
Authors: Wang Yu , Ling Yuwei , Li Kaifu , Zhang Yan , Zhao Ye , Kang Hua
Published: August 2021

Background: Malignant adenomyeloblastoma is a rare tumor, with no guidelines available for its treatment. Case presentation: We discuss a case of malignant adenomyeloblastoma of the right breast in a 59-year-old woman. The patient underwent a lumpectomy, and pathological diagnosis of malignant adenomyeloblastoma was distinct from the preoperative needle-biopsy diagnosis of intraductal papilloma. The patient underwent mastectomy and chemotherapy immediately. However, local recurrence was occurred 11 months after the initial operation. We summarize the characteristics of patients with malignant adenomyeloblastoma in PubMed and Web of Science databases, and share our experience and discoveries. Statistics included the univariate and multivariable Cox proportional hazards models. Overall, 34 patients were analyzed. Conclusions: At diagnosis, the median age was 59.3 years and the median tumor size was 30.0 mm. The most common initial surgery was breast-conserving surgery (50%), and a proportion of patients underwent axillary lymph node dissection (32%). Age, max diameter, and axillary status were associated with overall survival. Complete surgical excision with adequate margins is the most important treatment. Patients may not benefit from remedial adjuvant therapy, but may benefit from prompt postoperative adjuvant therapy. Multidisciplinary cooperation and follow-up are essential for the management of these patients. Our data would provide novel insights into a rare tumor that might avoid over- or under-treatment of the patients.
Case study: Awareness of indigenous knowledge associated with traditional herbs for health and sustainable development
Authors: Gupta Astha , Raj Priyaranjan , Lama Pemala Khyungba , priya Pragati , Kumar Utsav , Lalmuansangi C , Dolo Yame
Published: August 2021

Background

Traditional herbs are renowned from very ancient time due to historical, mythologicaland medicinal significance. In present scenario, traditional herbs are “Necessity of the new era” because they are also effective for deadly coronavirus disease (COVID-19).
Methods

To explore to pre-existing knowledge of traditional herbs, we investigated good numbers of participants from different location and age group. Most of the participants belong from age group of 18–25 (79.4%) followed by age group 26–30 (11.8%). Remarkably, good number of female candidate (58.8%) was actively involved as compared to male candidates (41.2%). Maximum number of peoples (26.5%) responded from Kathmandu (Nepal) and Mizoram, (India) followed by Nepalgunj (17.6%, Nepal) and Uttar Pradesh (11.8%, India).
Results

Interestingly, 82.4% peoples were aware about medicinal plants and 73.5% showed interest for learning. However, 64.7% and 35.3% peoples prefer medicinal herbs and pharmaceutical medicines respectively. Some participants explained that medicinal herbs are effective without side effects but very slow and are not helpful in emergencies. As data indicated 76.5% individuals were given the positive attention for medicinal plants farming.Data depicts that 82.4% individuals have been tried the medicinal herbs (turmeric, basil, giloy and aloe vera) in daily life and cured but 17.6% individuals were not cured after application. Besides, 11.8 % peoples were allergic and rest of the 88.2 % peoples was non-allergic to medicinal herbs and feel considerable positive effect (refresh, relax and glowing skin). Good number of the candidates was known to tulsi (70.6%) and aloe vera (64.7%). However, 14.7% peoples were unconvinced for medicinal herbs efficiency.
Conclusion

Traditional herbs are undervalued due to lack of knowledge/awareness and low availability in market. Therefore, present survey would be useful for society awarenessand daily consumption may improve the physical and mental health. In future, herbs farming would be good choice for extra income source and sustainable development in both rural and urban community.
Nonlocal Euler-Bernoulli Beam Theories with Material Nonlinearity and their Application to Single-Walled Carbon Nanotubes
Authors: huang kun , Qu Benning , Xu Wei , Yao Ji
Published: August 2021

The small-scale effect and the material nonlinearity significantly impact the mechanical properties of nanobeams. However, the combined effects of two factors have not attracted the attention of researchers. In the present paper, under the displacement’s Euler-Bernoulli assumption, we proposed two new nonlocal models to describe the mechanical properties of slender nanobeams for two centroid locus conditions: the locus extensibility and the locus inextensibility. Two new theories consider both the material nonlinearity and the small-scale effect induced by the non-local effect. The new models are used to analyze the static bending and the forced vibration for single-walled carbon nanotubes (SWCNTs). The results indicate that the stiffness’ softening effect induced by the material nonlinearity has more prominent impact than the nonlocal effect on SWCNT’s mechanical properties. Therefore, neglecting the material nonlinearity may cause qualitative mistakes.
The association between serum albumin and LOS of patients with acute heart failure: a retrospective study based on the MIMIV-IV database
Authors: Liu Tao , xuan haochen , wang lili , li xiaoqun , lu zhihao , tian zhaoxuan , chen junhong , wang chaofan , li dongye , xu tongda
Published: August 2021

Objective: To assess the relationship between serum albumin and length of stay (LOS) of the intensive care unit (ICU).Design and Participants: we retrospectively analyze 2280 patients with acute heart failure(AHF) from the medical information mart for intensive care IV (the MIMIC-IV ) database. Materials and Methods: The exposure variable of the present study was serum albumin. The outcome variable was LOS. The final models were established by multivariate linear regression, and subgroup analysis was performed. Trend test and smooth fitting curves were used to evaluate the association between serum albumin and LOS. Results: When the value of serum albumin was less than 5.1g/dl, the analysis of 2280 patients showed that the linear relationship between albumin and LOS. LOS was gradually shortened with the albumin increasing (β: -0.636; 95%CI: -0.819, -0.453; P <0.001). In subgroup, sepsis and serum albumininitial had an interactive effect on LOS (P=0.036), and there was significantly different between AHF patients with sepsis (β:-1.927; 95%CI:-3.823, -0.030) and without sepsis(β: -1.412; 95%CI:-1.737, -1.087) .Conclusion: When serum albumin was less than 5.1g/dl, the negative association was presented between serum albumin level and LOS among patients with AHF, and this association is even closer in patients with sepsis.
Effectiveness of Ivermectin/Doxycycline combination in COVID-19: a systematic review and meta-analysis
Authors: Omrani Mohammad Ali , Salehi-Abargouei Amin , Heydari Behrooz , Kermanshahi Nazgol , Joukar Fatemeh , Aryanfar Amir
Published: August 2021

BackgroundThis systematic review and meta-analysis aimed to assess the efficacy of the Ivermectin/Doxycycline combination for the treatment of coronavirus disease 2019 (COVID-19).MethodsWe searched PubMed, Web of Science, Scopus, ClinicalTrials.gov, and Google Scholar from database inception to August 26, 2021 for relevant studies. We included studies reporting at least one of the outcomes of interest: all-cause mortality; time to clinical recovery; hospital stay and viral clearance. The logarithm of risk ratios or mean differences and their corresponding standard errors for each outcome were pooled using a random-effects model. The risk of bias was assessed using the Cochrane Collaboration's tool for randomized clinical trials and the Newcastle-Ottawa Scale for cohort studies.ResultsFour randomized clinical trials and one prospective study involving 789 patients, including 399 in the Ivermectin/Doxycycline group and 390 in the control group, were enrolled. The all-cause mortality rate of patients with COVID-19 in the Ivermectin/Doxycycline group was 0.79% (2/253), which was lower than in the control group (3.6%; 9/250). However, the difference was not statistically significant (Log risk ratio=-1.288; 95% CI:-2.671, 0.096; P = 0.068; I2 = 0%). The effect of Ivermectin/Doxycycline on time to clinical recovery was found to be significant (Difference in means =-2.427 days; 95% CI:-4.033, -0.820; P = 0.003, I2 = 91.475%). There is no significant effect of Ivermectin/Doxycycline on hospital stay (Difference in means =-0.379 days; 95% CI:-1.965, 1.208; P = 0.640, I2 = 91.95%) and time to negative PCR or viral clearance (Difference in means =-0.768 days; 95% CI:-1.550, 0.013; P = 0.054, I2 = 91.48%).DiscussionBased on low-quality evidence, this meta-analysis showed that Ivermectin/Doxycycline combination is accompanied with shorter time of clinical recovery in COVID-19 patients. However, it did not reduce all-cause mortality, viral clearance, and hospital stay significantly. Not only the number of the studies are limited but also they ranked methodologically medium to low with limited participants. To assess the exact effective dose and efficacy of this combination therapy, high-quality and large-scale randomized clinical trials are needed.OtherThis study was registered in Prospero (registration number: CRD42021272400). The authors declare they have no competing financial interests.
A formula for calculating the rotational period of planet or star
Authors: zhai xiaozhong
Published: August 2021

This paper reports a formula for calculating the rotation period of planet or star. The rotational radius, the orbital velocity and the gravitational acceleration at its surface, the three factors, determine the rotational period of planet or star.
A REVIEW: IMPACT OF SOIL SALINITY ON ECOLOGICAL, AGRICULTURAL AND SOCIO-ECONOMIC CONCERNS
Authors:   V.P. & R.P.T.P. Science College, VallabhVidhyanagar., N. Thaker Pooja , Brahmbhatt Nayana ,   V.P. & R.P.T.P. Science College, VallabhVidhyanagar., Shah Karishma ,   V.P. & R.P.T.P. Science College, VallabhVidhyanagar.
Published: August 2021

In recent years, salinization of soil is one of the challenging environmental concerns occurring all over the world. The effects of concentration of salt can be detected in both natural (primary) as well as man-made (secondary) environment. This is due to massive urbanization and industrialization in coastal regions, Soil salinity may lead to degradative changes in the composition of natural water resources, loss of fertile soil, loss of biodiversity, changes in local climatic conditions which in turn affects many aspects like, increasing salinization (salt affected soil) of lands converted in to non-productive conditions which significantly affects human life and posing major interruption to the economic development of farmers and their economy in the country. Furthermore, the overview of salinization and its effects on ecology, agriculture and economic growth and development is presented in this paper. Purpose of this review paper represented is according to most recent literature and refines knowledge on consistent research efforts for the types of soil salinity, problems of soil salinization, effect on plant growth and management strategies in agriculture to mitigate soil conditions in the salinity affected areas as well as rise in crop productivity and suggests future perspectives for on-going salinity research in the country.
EFFECTIVENESS OF ROBOTIC-ASSISTED GAIT TRAINING IN STROKE REHABILITATION: REVOLUTION IN PATIENT OUTCOME
Authors:   Physiotherapy Specialist, Qatar Rehabilitation Institute., Annethattil Amjad , Prabahar Pushparaj Joseph ,   Qatar Rehabilitation Institute, Doha, Qatar., Sabbagh Ayman ,   Qatar Rehabilitation Institute, Doha, Qatar., Farraj Mohammad ,   Qatar Rehabilitation Institute, Doha, Qatar., Muniraj Manoj ,   Qatar Rehabilitation Institute, Doha, Qatar., Ahmadul Al-Madzhar ,   Qatar Rehabilitation Institute, Doha, Qatar., Khairallah Leila ,   Qatar Rehabilitation Institute, Doha, Qatar., Mohmamed Abdullah Saad Rafat ,   Qatar Rehabilitation Institute, Doha, Qatar.
Published: August 2021

Objective: To evaluate the effectiveness of robotic-assisted gait training (RAGT) in improving the functional outcomes among stroke survivors Design: Retrospective matched control study. Setting: Inpatients stroke unit, Qatar Rehabilitation Institute. Outcome Measures: The Functional Ambulation classification (FAC), The Functional independence measure (FIM), The Berg Balance Scale (BBS), The Dynamic Gait index (DGI), The Ten-meter walk test (10MWT), The timed up and Go test (TUG) and the Five times sit to stand (5XSTS) Data Analysis: A retrospective comparison of stroke patients who received robotic assisted gait training performed statistically using the 20th version of SPSS statistical package (SPSS Inc. Chicago, IL, USA) Study Procedures: The investigators reviewed the medical records, the physiotherapy treatment sessions records and data from the Clinical Management System of Qatar rehabilitation institute of the patients during the period from 1stJanuary 2018 to 31 December 2019. RAGT group was created to assign the patients who received more than four RAGT sessions. The other group was created from the patients who completed the stroke rehabilitation program without RAGT to cross match Conclusion: All the outcome measures were compared between admission and discharge regardless of their group and found that there was a good improvement in the outcome and statistically significant (p value 0.0001) While comparing the lokomat and non lokomat group in functional outcome measurements lokomat group (RAGT) had significant improvement in discharge scores.
CONTRIBUIÇÕES DO CÍRCULO DE CULTURA À PARTICIPAÇÃO POPULAR NA GESTÃO DA EDUCAÇÃO BÁSICA: DIÁLOGOS COM PAULO FREIRE
Authors: Tomelin Nilton Bruno , Rausch Rita Buzzi
Published: August 2021

O presente estudo tem como objetivo identificar possíveis contribuições do Círculo de Cultura à participação popular na gestão da educação básica numa perspectiva democrática. Trata-se de uma pesquisa teórica fundamentada no pensamento de Paulo Freire. O estudo sinaliza que uma gestão democrática na educação básica, nesta perspectiva, implica em assumir valores como comunhão, iniciativa, reciprocidade, comprometimento e solidariedade. Desta forma o Círculo de Cultura é uma alternativa possível à uma educação popular e ao protagonismo da participação popular na sociedade.
Paulo Freire: Gestão Democrática em três formações
Authors: Kruppa Sonia Maria Portella , Telles Silvia Andrade da Silva , Angelo Aline Aparecida
Published: August 2021

O artigo aborda três formações baseadas na gestão democrática de Paulo Freire, a partir da Educação Popular e da extensão universitária: o MOVA-SP, a Licenciatura em Educação do Campo e o Núcleo de Avaliação Institucional da FEUSP. A força e atualidade deste autor estão na gestão participativa, democrática e dialógica de diferentes coletivos em defesa de uma educação libertadora. São relatos que anunciam elementos para políticas alternativas e novas formas de organização da educação. São possibilidades contra hegemônicas a propostas conservadoras de conceber e fazer a gestão do trabalho pedagógico.
A CULTURA DO SILÊNCIO: CULTURA DE POBREZA, DOMINAÇÃO E PEDAGOGIA DA LIBERTAÇÃO
Authors: Silva Alberto , Sguissardi Valdemar
Published: August 2021

Artigo publicado originalmente com o nome "Culture de pauvreté, domination et pédagogie de la libération", no número 47 da Revista francesa Orientations, em julho de 1973.
Diacetate Naphthoquinone Derivatives Tethered to 1,2,3-Triazoles: Synthesis and Cytotoxicity Evaluation in Caco-2 Cells
Authors: Costa Dora , Francisco Adriane , Matuck Beatriz , Furtado Priscila , de Oliveira Alana , Rabelo Vitor , Sathler Plínio , Abreu Paula , Ferreira Vitor , da Silva Luiz Cláudio , da Silva Fernando
Published: August 2021

Acetylated compounds prepared from naphthoquinones have been reported as antitumoral prodrugs. Exploring the synthetic versatility of the naphthoquinone and triazolic nuclei, herein we report a simple and efficient synthetic route to prepare a series of sixteen prodrugs prototype of 1,2,3-triazoles-naphthoquinodoic acetyl derivatives. The compounds 10a-10h and 11a-11h were obtained by oxidative cycloaddition reaction between lawsone and 4-vinyl-1H-1,2,3-triazoles promoted by ceric ammonium nitrate (CAN) in alkaline medium followed by reductive acetylation of the quinones in excess of metallic zinc and acetic anhydride in yields up to > 98%. All derivatives revealed to be hemocompatible and the compound 11e exhibited the most promising profile against Caco-2 cells showing the higher selectivity index. Molecular docking suggests that these compounds could exert their cytotoxic activity through inhibition of one topoisomerase II isoform, at least.
Mature Cystic Teratoma of the Ovary; Clinicopathological Evaluation of 143 Cases in our Series, 5 Years Experience
Authors: Ogut Betul , Kazanci Ferah , Yapar Dilek , Erdem Özlem , Onan M.Anil
Published: August 2021

OBJECTIVE: Mature cystic teratoma, also known as a dermoid cyst, is the most common germ cell tumor of the ovary. In this retrospective study, it is aimed to evaluate clinicopathological findings of the patients who were operated on due to the preliminary diagnosis of dermoid cyst.
STUDY DESIGN: Between May 2013 and May 2018, the findings of a total of 143 patients who were operated on with a preliminary diagnosis of dermoid cyst in our institution were analyzed retrospectively. In addition to demographic characteristics such as age, parity number and tumor size, lateralization, preoperative tumor markers, surgical procedure, presence of other pathological findings, and the rate of malignant transformation were analyzed.
RESULTS: The median age of patients was 35.4 years and the ratio of nulliparous, primiparous, and multiparous patients was 46.9%, 25.2%, and 28%, respectively. The median tumor diameter was 6.7 cm, 50.3% of which were right-sided, 46.9% were left-sided and the remaining 2.8% were bilateral. Intraoperative torsion was found in 15 (10.5%) cases. The treatment consisted of 60.1% cystectomy by laparoscopy, 3.5% unilateral salpingo-oophorectomy by laparoscopy, 9.8% unilateral salpingo-oophorectomy by laparotomy, while the rate of 16.1% cases underwent hysterectomy with bilateral salpingo-oophorectomy by laparotomy, 10.5% of the cases, cysts were excised during cesarean section. As the final pathology report revealed, of 143 patients, immature teratoma was observed in five cases (3.5%), in one of them (0.7%) mixed germ cell tumor and in three of them (2.1%) borderline mucinous cancer, squamous cell carcinoma, and carcinoid tumor on mature cystic teratoma base were observed.
CONCLUSION: Torsion is the most common complication with mature cystic teratoma. The size of the tumor is an important prognostic factor in terms of the malignant transformation of teratoma. Fertility sparing surgery with a minimally invasive surgical approach is available for fertility patients diagnosed with Mature cystic teratoma.
The Impact of P53 and KI67 Expression in Endometrial Cancer and its Effect on Survival
Authors: Sahin Zekiye , Bayraktar Burak , Karadeniz Tugba , Sarici Muzaffer
Published: August 2021

OBJECTIVE: This study was conducted to evaluate the relationship of p53 and Ki67 expression with prognostic factors in patients who underwent surgery due to a diagnosis of endometrial cancer, and to evaluate their use as molecular markers that can help with survival prediction.
STUDY DESIGN: This retrospective cohort study included patients who underwent surgery for endometrial cancer indication at the Gynecologic Oncology Clinic of the University of Health Sciences Tepecik Training and Research Hospital between 2011 and 2019, and whose p53 and Ki67 from the dissected material were pathologically studied and who underwent pelvic/paraaortic lymph dissection between the relevant dates.
RESULTS: The study included 140 patients who met the inclusion criteria, 60% (n=84) of whom had endometrioid type endometrial carcinoma and 40% (n=56) had non-endometrioid type endometrial carcinoma. Estrogen and progesterone receptor positivity was significantly higher in the endometrioid type endometrial carcinoma group (p<0.001 and p<0.001, respectively). The non-endometrioid type endometrial carcinoma group had a high degree of positive staining (+3 and +4 staining) with p53 was 51.8%, while this rate was 11.9% in the endometrioid type endometrial carcinoma group. The non- endometrioid group also had a high degree of positive staining of Ki67 at 51.8%, whereas the endometrioid group had 25%. The total staining rate with p53 and Ki67 was significantly higher in the non-endometrioid type group (p<0.001 and p=0.001, respectively). The mean survival duration was less than six months in cases with high degree positive p53 [57.4±2.7, (52.1-62.8) vs 51.9±5.9, (41.8-61.9)] and the mean survival duration was less than eight months in cases with high degree positive Ki67 [59.6±2.9, (53.8-65.4) vs 51.6±4.3, (43.2-60.1)].
CONCLUSION: p53 and Ki67 can be new markers for the prediction of prognosis and duration in endometrial cancer. The results of this study pave the way for new studies: however, randomized controlled prospective and multi-center studies are needed for immunohistochemical measures to be used as a parameter.
The water dispatching of river basins during dry periods under the most stringent water management system in China
Authors: He Yanhu , Gong Zhenjie , Zheng Yanhui , Bai Xiaoyan , Wang Peng
Published: August 2021

Since 2011, China has implemented its most stringent water management system to effectively protect water resources and guarantee socioeconomic development. More basin-scale water division schemes have been developed to act as references for basin-scale water resources management. Water dispatching during dry periods is an effective way to guarantee the water supply for the river basin, and is also an important component of basin-scale water resources management. Given this, the present study proposes a framework for the water dispatching of river basins during dry periods under the most stringent water management system in China. This framework mainly consists of the analysis and forecasting of rainfall and inflow, the dispatching requirements for the main water users, major reservoirs, and sections, as well as safeguard measures. The Jian River Basin in South China is presented as a case study. The total discharge of the Gaozhou Reservoir in 2017 was 25 million m3 more than the target discharge specified in the water dispatching scheme, and the total water storage utilization ratio during the dispatch period was 4.7% higher than the target utilization ratio. These factors demonstrate the effectiveness and applicability of the proposed framework.
An analytical model for vortex at vertical intakes
Authors: Sarkardeh Hamed , Marosi Morteza
Published: August 2021

In the present paper, free surface vortex formation at intakes is investigated analytically. By assuming a spiral form for vortex streamlines, continuity and momentum equations were integrated and solved in a vortex flow domain. From this solution, velocity and pressure distributions were found above the intake under vortex action. An equation for the water surface profile was also found and compared with another research. By considering that in an air core vortex, pressure at the intake entrance drops to zero, a relationship was found for critical submerged depth and verified by experimental data and another analytical equation. It was concluded that the results of the proposed spiral analytical model had good agreement with the experimental data.
La Participación Ciudadana desde un Acercamiento Sociopolítico. Una Perspectiva del Docente Universitario
Authors: Abraham Abraham Alfredo Hernández Paz , Hernández Pedro Paul Rivera , Mejía Dave Alexander López
Published: August 2021

La participación ciudadana ha sido por mucho un tema de constante estudio, donde se han generado diversos modelos y acercamientos según los tipos de democracias acorde tiempo y espacio del entorno social. En este artículo se hace una revisión sobre los modelos de participación ciudadana y la perspectiva que tiene el docente universitario desde el ámbito comunitario, pues se busca identificar que perciben los trasmisores del conocimiento acerca de la participación, desde lo personal hasta sus experiencias vividas como habitantes dentro de una comunidad; en lo que corresponde a la metodología del estudio es de corte cualitativo, ya que se aplicaron entrevistas semiestructuradas. Los objetivos del presente estudio consisten en indagar cuáles son las perspectiva de los docentes universitarios con relación a la participación ciudadana en espacios comunitarios, de igual forma, conocer las causas o factores que, en opinión de los docentes universitarios influyen o no en las y los ciudadanos para participar en sectores comunitarios, así como comprobar la existencia de acciones sociales impulsadas por instituciones universitarias que motivan al alumnado a participar en actividades cívicas.
Decrescimento na Perspectiva das Cidades em Transição: Resiliência e Ética Socioambiental
Authors: Alcântara Liliane Cristine Schlemer , Sampaio Carlos Alberto Cioce
Published: August 2021

Na esteira da instabilidade socioeconômica e destruição dos ecossistemas, certas dinâmicas sociais e ecológicas surgem ancoradas nos princípios do Decrescimento e das Cidades em Transição. O objetivo deste artigo é apresentar o estado da arte do Decrescimento e avançar sua correlação com casos emblemáticos de Cidades em Transição. Metodologicamente realizou-se revisão de literatura em profundidade e análise crítica e descritiva sobre iniciativas em transição no Brasil e no mundo. Os resultados levam a crer que o principal desafio dessas iniciativas gira em torno da criação de redes populares capazes de transformar comunidades em modelos sustentáveis, integrados à natureza. Demonstrar que Cidades em Transição à luz do Decrescimento configuram-se como uma alternativa de desenvolvimento viável quando implantado em agrupamentos populacionais com escala reduzida. Percebeu-se que os movimentos analisados apresentam uma discussão ética ambiental, que pode efetivamente reduzir a pegada de carbono e aumentar a resiliência das comunidades urbanas frente a crise socioeconômica e ambiental.
Response Control of Structures with Friction Dampers under Blast Loading
Authors: Gowda Kiran Kupphalli Krishne , Farsangi Ehsan Noroozinejad
Published: August 2021

Introduction:

This study investigates the performance of the surface blast load acting on Moment Resistance Frames (MRF)with a novel slip load friction damper. Recently the world is facing terrorist activities that lead to the damage of the structures, including commercial, industrial, and public buildings.

Methods:

These structures should be protected by using control devices. Friction damper is a passive damping device that absorbs maximum energy released during vibrations. Blast loads are calculated based on empirical equations.In this study, single slip and double slip load friction dampers considering the hysteresis loops are used for controlling the response of the MRFs exposed to blast loadings.

Results:

The four storey, eight storey, and twenty storey MRFs with surface blast responses are controlled by using single and double slip load friction dampers. The response includes displacement, accelerations, velocity, storey drift, storey drift ratio, pressure impulse curve, etc. The torsional effect with two dimensions is considered for the high-rise structure as well.

Conclusion:

It was concluded that using friction dampers plays a vital role in controlling the response of MRFsunder blast loadings.