bluuebunny/crossref_metadata_2025 huggingface dataset:
Saga literacy
Authors: Domsa Zsófia
Published: June 2022

Tanulmányom a tanulási célú irodalomolvasás kontextusában olyan kognitív didaktikai szempontokat tárgyal, amelyek segítik a kevésbé avatott olvasó útját az izlandi nemzetségsagák világában. A kognitív irodalomdidaktika ezáltal a természetes olvasást és a professzionális irodalomértést közelíti egymáshoz. Az izlandi nemzetségsagákra jellemző tömör eseményleírásból hiányoznak az érzelmek, ami az emlékezeti befogadókészséget megnehezíti. A kognitív didaktikai megközelítés ennek az akadálynak a tudatában kínál olyan befogadási sémát, amelyet a hosszabb és bonyolultabb cselekményű szövegek esetében is alkalmazhat a befogadó. Magne Drangeid három perspektívát ajánl az irodalmi művek oktatásban való tárgyalásához. Az első perspektíva azt vizsgálja, hogy az olvasó hogyan navigál a szövegben, a második megfigyeli, hogy az olvasó miként egészíti ki a szövegből kapott információkat, hogy teljes világot építsen, a harmadik szempont pedig az olvasott mű elvont értelmét, metaforikus jelentéstartalmát firtatja. Tanulmányomban e három perspektíva vizsgálatának bevonásával amellett érvelek, hogy a negatív érzelmeket kiváltó mozzanatok a sagák szövegében a befogadást segítő narratív horgonyként működnek.
Is the Sarcasm of M.E. Saltykov-Shchedrin Justified in the Political and Legal Context of the Era of Alexander II? (On the Example of the Novel "The History of a Town"). (On the example of the novel "Stories of a city").
Authors: Shibanov Alexei
Published: June 2022

The article examines the legislative transformations in Russia in the 60–70 years of the XIX century in the political and legal context of the era of Alexander II, as well as the interpretation of these events by M.E. Saltykov-Shchedrin. In The History of a Town, the writer allegorically depicts the city governors, the legislative system and the social structure of Russia in its historical past and post-reformation contemporary time, but the writer's sarcasm is not directed against the Russian people, its historical fate. Polemizing with Russian history presented by the official ideology, Shchedrin tries to find the optimal solution to the problem of law and justice as the basis of the state structure and depicts satirical overthrow of the system of public administration. According to the writer, the reforms coming from "above" are doomed to failure because of their non-viability in the natural course of historical events.
Linguistic and Extralinguistic Features of Linguistic Persona of the Interpreter
Authors: Ulanova Ekaterina
Published: June 2022

In the article the author considers the problems of simultaneous interpreting, focusing on the influence of linguocultural and extralinguistic features of linguistic identity in the interpreting of the TV interview genre. The research is conducted on the material of mass media discourse. The research methods include linguistic analysis of linguistic persona in the interview, cognitive and discursive analysis of the representation of linguistic persona in the interview, the interpretive analysis of simultaneous interpretations. The research results in the description of linguistic and extralinguistic features of the linguistic persona in the interview genre, directly affecting the interpreting process; features of simultaneous interpreting of an interview, analysis of problem situations in the process of interpretation of the television interview.
Sinais-termo correspondentes a território nas provas do Enem
Authors: Felten Eduardo Felipe
Published: June 2022

Este artigo objetiva mostrar as diferentes unidades terminológicas sinalizadas (UTS) empregadas por tradutores no caderno de Ciências Humanas e suas Tecnologias do Exame Nacional do Ensino Médio (Enem) em Língua Brasileira de Sinais (Libras). As UTS são as que correspondem ao termo "território" em português, verificadas nas videoprovas do Enem aplicadas nos anos de 2017, 2018 e 2019. A partir da análise proposta, apresentamos reflexões que visam encontrar estratégias adequadas para a lematização das UTS em glossário semibilíngue de caráter didático-pedagógico Libras-Português. A análise realizada por nós tem base em pressupostos da Teoria Sentido-Texto (TST), particularmente na abordagem Léxico-Semântica para a estrutura de Terminologia proposta por Marie-Claude L’Homme (2004). Além disso, buscamos apoio teórico nos princípios da diferenciação entre Lexicografia e Terminografia em Bevilacqua e Finatto (2006) e da Terminografia Didático-Pedagógica (TD-P) (FADANELLI, 2017). Como resultado da análise, foi possível pensar em critérios para que os sinais-termo correspondentes possam ser lematizados em glossário semibilíngue de caráter didático-pedagógico. Este estudo nos permitiu propor axiomas que orientam a elaboração de uma obra terminográfica semibilíngue destinada ao público surdo do ensino médio.
GEOTRILHA: INTERPRETAÇÃO AMBIENTAL NO DESENVOLVIMENTO DE AÇÃO EDUCATIVA SOBRE GEODIVERSIDADE
Authors: de Oliveira Gladson , Oliveira Fábio Soares de , Moreira Alexa Carmo Testi
Published: June 2022

Este estudo apresenta uma proposta de ação educativa e meios de interpretação ambiental para o percurso de trilhas, integrando os princípios da geodiversidade. Esta é uma das possibilidades de planejamento do uso, baseado na avaliação da paisagem na perspectiva integrada da geoecologia podendo, inclusive, contribuir para a preservação da diversidade geográfica local. O trabalho foi conduzido no Museu de História Natural e Jardim Botânico (MHNJB) da UFMG, a partir da aplicação prática dos resultados do levantamento e análise espacial de diversos elementos da paisagem. Assim, a análise integrada dos geofatores, associada à cartografia da paisagem, permitiu a formulação de um traçado, e perfil geoecológico, para uma trilha interpretativa com o tópico geodiversidade, chamada de geotrilha, possibilitando uma gama de temas interpretativos que podem vir a ser trabalhados. A aplicação da geoecologia demonstrou como a interpretação ambiental em trilhas, principalmente em áreas protegidas, é um importante instrumento educacional e de divulgação científica para a Geografia.
A FARINHADA COMO ESTRATÉGIA DE MANUTENÇÃO DA CONDIÇÃO CAMPONESA DIANTE DOS EUCALIPTAIS NO BAIXO PARNAÍBA (MARANHÃO, BRASIL)
Authors: Botelho Adielson Correia
Published: June 2022

O Baixo Parnaíba, no estado do Maranhão, Brasil, caracteriza-se como o novo “Eldorado do Agronegócio”. Destaca-se, o avanço dos plantios de eucalipto e a pressão fundiária na região cada vez mais presente. Por outro lado, os camponeses usufruem da farinhada como a principal estratégia econômica para resistir na luta pela/na terra e assegurar a sua manutenção. Baseados em pesquisas de campo (empírica), levantamento bibliográfico e documental, evidencia-se que, no período entre 1990 e 2018, o Baixo Parnaíba viveu importantes transformações em espaço agrário. Observa-se que a farinhada representa, mais que uma estratégia econômica, ela concretiza-se como processo de sociabilidade, momento em que o grupo compartilha conhecimentos, valores culturais, regras, costumes, trocas de produtos importantes para assegurar a condição de reprodução social do grupo.
CARTOGRAFIA GEOMORFOLÓGICA E COMPARTIMENTAÇÃO MORFOESTRUTURAL NA BACIA DO RIO NOVO (MG): SUBSÍDIO À COMPREENSÃO DA MORFOGÊNESE NA REGIÃO DOS GRANDES ESCARPAMENTOS DO ESCUDO ATLÂNTICO
Authors: De Paiva Derik Ribeiro , Marques Neto Roberto
Published: June 2022

O presente artigo tem por objetivo divulgar os resultados obtidos com o mapeamento geomorfológico e a compartimentação morfoestrutural da bacia do rio Novo (MG) como ferramentas para a interpretação da evolução do relevo regional. A carta geomorfológica correspondente, editada na escala de 1/50.000, foi concebida em consonância ao plano metodológico estabelecido pelo Instituto Brasileiro de Geografia e Estatística. O trabalho possibilitou mapear unidades geomorfológicas ordenadas em padrões de formas semelhantes segundo os modelados de dissecação e agradação identificados e seus aspectos morfométricos fundamentais (declividade, profundidade de dissecação e amplitude interfluvial). Em um segundo nível de abordagem, foi empreendida a inserção de símbolos representativos de feições morfológicas e processos atuais (escarpas, ravinas, focos de arenização, capturas fluviais). Finalmente, o mapa geomorfológico gerado foi associado aos litotipos existentes e aos lineamentos estruturais extraídos a partir do relevo e da drenagem para elaboração da compartimentação morfoestrutural da bacia, exaltando o papel da cartografia geomorfológica como importante ferramenta para os estudos de cunho morfogenético.
Das críticas de Herbert Marcuse a Wilhelm Reich
Authors: Matthiesen Sara Quenzer
Published: June 2022

Resumo: Uma análise da crítica que Herbert Marcuse dirige a Wilhelm Reich, em Eros e civilização, aponta o abandono dos "vislumbres crítico sociológicos" e que levaram Reich a orientar a Psicanálise "no sentido da relação entre as estruturas social e instintiva", salientando o "grau em que a repressão sexual é imposta pelos interesses de dominação e exploração", em prol de um "primitivismo arrasador", sinônimo, talvez, de uma "racionalidade instintiva" no âmago do pensamento reichiano, cuja análise conceitual revelou significados coerentes com a proposta de trabalho muitas vezes distorcida de Reich e que permitem um diálogo com a "dimensão biológica" marcuseana.
 
Abstract: An analysis of the criticism that Herbert Marcuse adresses to Wilhelm Reich in Eros and civilization, points out the abandoning of the "critical-sociological glimmers" and that took Reich to orient the Psycoanalysis "in the sense of the relation between the social and the instintive structures", salienting the grade in which the sexual repression is imposed by the interests of domination and exploration, in behalf of a "crushing primitivism", similar maybe, of an "instintive rationality" in the heart of Reichian thinking, which conceptual analysis revealed meanings coherent with the proposal work-many times distorted -of Reich and that allow a dialogue with the Marcuse's "biological dimension".
Eclosão no Brasil das vertentes positivistas
Authors: Carvalho José Maurico de
Published: June 2022

Resumo: Este trabalho traça o perfil das principais vertentes do positivismo brasileiro e explica suas especificidades a partir da herança lusa. Os moralistas da geração pombalina semearam certas crenças que irão influenciar no modo como os ideais positivistas foram veiculados no Brasil. Esta circunstância explica as diferenças entre as vertentes francesa e brasileira do movimento.
Palavras-chave: positivismo; vertentes; moral; sociedade; polítical.
 
Résume: Ce travail trace le profil des principaux versants du positivisme brésilien et explique leurs spécificités à partir de l'héritage lusitanien. Les moralistes de la génération pombalienne ont cultivé certaines croyances qui influenceront de la manière où les idéaux positivistes ont été véhículé au Brésil. Cette circonstance explique les différences entre les versants français et brésilien du mouvement
Mots-clé: positivisme; versant; morale; societé; politique.
Especialização em ensino de geociências:
Authors: Negrão Oscar Braz Mendonza
Published: June 2022

Resumo: No início da década de 80, a Sociedade Brasileira de Geologia promoveu pesquisa-diagnóstico que confirmou a necessidade e importância de formação pedagógica para os professores dos cursos de graduação em Geologia. Parte das sugestões e reivindicações que surgiram então no âmbito da comunidade geológica, no sentido de contemplar essa formação, foram atendidas com o oferecimento do Curso de Especialização em Ensino de Geociências na UNICAMP, a partir de 1984. Destinado a professores de disciplinas geológicas e afins, usualmente graduados em Geologia, Geografia, Engenharia e Ciências Biológicas, o curso é estruturado em três fases, nas quais o participante executa atividades respectivamente de planejamento de ensino, aplicação desse planejamento e, finalmente, avaliação do conjunto da experiência. O trabalho do participante na própria instituição de origem constitui o ponto de partida para seu aprofundamento teórico e também a meta a ser atingida, na forma de trabalho renovado. A análise sistemática do curso permitiu detectar deficiências e propor mudanças visando aperfeiçoá-lo.
Palavras-chave: Educação permanente; Geociências; Metodologia de ensino.
 
In the beginnings of the 80's the Brazilian Geological
Abstract: Society sponsored a research that confirmed the need and importance of pedagogic development for undergraduate courses's teachers in geology. A group of suggestions and demands that arose in the midst of the geological community, aiming at this development were met with the offer of the "Specialization Course in the Teaching of Geosciences" at UNICAMP since 1984. Directed to teachers of geological subjects and similar ones, usually graduate in geology, geography, engineering and biological sciences, this course is organized in three stages, where the student is engaged in activities of teaching planning, use of this planning and assessment of this overall trial. The previous work of the participant in his/her original institution set the starting point to the theoretical in-depth study, and also the goals to be attained. This research is oriented to the systematic analysis of this course, aiming at detecting deficiencies and proposing changes that may lead to its improvement.
Descriptors: Continuing education; Earth science; Teaching methods.
Gênese do pensamento pedagógico anarquista
Authors: Oliveira Leila Floresta de
Published: June 2022

Resumo: Este artigo constitui-se de uma discussão de aspectos do pensamento anarquista relevantes para compreender a formulação da questão educacional sob o prisma libertário. Nesse sentido, estabelecerei um contraponto entre um dos grandes expoentes fundadores do pensamento anarquista, Proudhon e o pensamento liberal e democrata, a partir de alguns conceitos caros a essas correntes de pensamento, uma vez que o pensamento libertário se constrói justamente a partir do diálogo com essas correntes de pensamento.
Abstract: This papear consists of a discussion on traits of anarchistic thinking that are relevent to the comprehension of how the education question is stated under libertarian viewpoint. will therein contrast one great distinguished founder of anarchistic thinking, Proudhon, and the liberal and democratic thought. This oppositions will be examined under some highly esteemed concepts from those thought currents, considering that the libertarian thinking is built exactly from the dialogue with them.
Upaya Peningkatan Kemampuan Guru Dalam Menyusun Perangkat Pembelajaran Melalui Kegiatan In House Training Pada Guru MGMP IPA Madrasah Tsanawiyah Kabupaten Sukabumi
Authors: Arifin Widad
Published: June 2022

Problems that often arise in educational institutions are the difficulty of getting teaching staff according to their fields, the limited number of permanent teachers, the inexperience of teaching teachers and the limited infrastructure in madrasas. Completeness of learning according to the KKM is still low, ranging from 40-60%. One of the efforts made is conducting In-House Training activities for teachers in MGMP associations in the preparation of teaching equipment as supervisory action research (PTKP). The purpose of this study was to improve the ability of IPA MGMP teachers in Sukabumi district in compiling teacher learning tools and determine the right steps to improve the ability of teachers in compiling teaching completeness. The research was conducted on teachers who were assembled in the IPA MGMP of Sukabumi Regency for approximately 6 months starting from July s / d. December 2020. Data collection was carried out through questionnaires, observation and documentation. From the questionnaire, it was found that overall the teacher stated it was important to have teaching completeness. The research was conducted in 2 cycles. In Pre-PTKP, only 62.72% of teachers can arrange learning tools, then in the first cycle there is an increase to 68.38%, then in the second cycle, there is an increase of up to 86.52% and all teachers in the preparation of learning tools are GOOD or have intermediate values 76 s / d. 90. All teachers want In-House Training for the preparation of learning tools and 100% of teachers to have high motivation to take part in In-House Training and have a strong desire to make learning tools and will use these learning tools to support the learning process.
Nilai Kejujuran dalam Pendidikan Karakter : Studi Hadis Bukhari No. 5629
Authors: Sahroh Alfi , Rizkiyah Nayla Na’imatur
Published: June 2022

Honesty is one of the basic forms in shaping a person's character, both from the family, school, and community environment. However, as time went on, the value of honesty began to erode. Corruption, cheating, plagiarism are one form of the erosion of the value of honesty. This paper will discuss the value of honesty by referring to the Hadith Bukhari no. 5629. This writing uses the ma'anil hadith method, examining the hadiths from takhrij hadiths, criticism of sanad, rawi, matan and understanding the meaning. The result of this writing is that Bukhari hadith no. 5629 regarding honesty is a valid hadith, both in terms of sanad, rawi, and mind. Understanding the ma'na with the language approach has also explained the essence of the ma'na contained in the hadith. The results of the implementation of the hadith show that the value of honesty in character education is formed from habits. Therefore, always speaking and being honest will lead to harmony and social order. Meanwhile, the habit of lying will lead to social conflict, both from real life and in cyberspace
Pengembangan Soal Berbasis HOTS (Higher Order Thinking Skills) pada Kurikulum 2013
Authors: Markhamah Naelatul
Published: June 2022

Changes in the form of education assessment in Indonesia is currently one of them is the implementation of based assessment HOTS (Higher Order Thinking Skills). The purpose of applying based assessment HOTS is to equip the ability of learners in facing their future in the 21st century, which includes skills as learners are required to think critically, creatively, innovatively, communicatively and collaboratively. Therefore, the purpose of this research is to find out the development of HOTS-based questions in the 2013 curriculum which includes the understanding of HOTS, hots characteristics, and steps for drafting HOTS Problems as well as examples of HOTS problems. The method used in this study is qualitative research with documentation data collection technique. The results of this study show that HOTS characteristics or High-level thinking skills include critical, logical, reflective, metacognitive and creative. The characteristics of HOTS are measuring the ability to think at a high level, using contextual-based problems, diverse questions, not familiar or routine and descriptions. Then, in the preparation of the questions, there are several steps, namely analyzing the Basic Competencies that can be made into the question, compiling a grid of questions, choosing a contextual and interesting stimulus and writing a question item that corresponds to the question grid as well as making rubrics or key answers.
Déconstruire l’« identité », théoriser la race
Authors: Brun Solène , Cosquer Claire
Published: June 2022

Les critiques des travaux sur les questions raciales dénoncent souvent la perspective « identitaire » qui y serait adoptée. Or l’usage du concept d’identité est âprement débattu en sciences sociales, des textes recommandant même son abandon (Brubaker, 2001). Cet article montre que la littérature sur la race permet de la théoriser, à l’encontre de toute compréhension essentialiste de l’identité, comme le produit de trois logiques imbriquées de formation raciale : auto-identification, assignation et socialisation. En interrogeant d’abord les déterminants sociaux des processus d’auto-identification et d’assignation raciales, l’article se tourne ensuite vers les pratiques sociales au fondement de ces modes de catégorisation, pour considérer la race comme ce que l’on fait plutôt que comme ce que l’on est. Nous explorons ainsi les différentes propositions théoriques qui permettent de penser la race comme principe d’action et de pratiques, comme performance réitérative ou comme incorporation de dispositions.
Ne pas se dire victime de racisme ?
Authors: Bouchareb Rachid
Published: June 2022

Les formes de qualification du racisme sont en partie structurées par un discours dominant imputant une étiquette de victime au minoritaire. Dans les récits d’expérience, comment comprendre que des minoritaires racisés soient réticents ou refusent de s’en dire victimes ? Partant d’une enquête par entretien (N=35) avec des minoritaires, descendants d’immigrés et de natifs des DOM-TOM, nous interrogeons la catégorisation profane des expériences et interactions racistes, en relation avec le cheminement identitaire et biographique des individus enquêtés. Nous montrons, dans un premier temps, comment leur définition de la situation met en jeu différentes stratégies identitaires, de conciliation ou de mise à distance de l’identité raciale imputée. Nous interrogeons ensuite la manière dont les épreuves vécues d’altérisation se jouent à l’échelle des interactions avec les majoritaires, mais aussi entre minoritaires. Elles conduisent à rendre incertaines tant l’identité personnelle de l’individu que la qualification du racisme.
The morphogenesis of religion and religious self-organization (with a focus on polytheism and Christianism)
Authors: Wildgen Wolfgang
Published: June 2022

Cognitive semiotics should not only use psychology and neurology as the background of multi-modal sign usage, but it must also take into account the biological, and specifically the evolutionary and developmental aspects of communication with signs, or in Cassirer’s terms, of “symbolic forms”. This article deals with questions of the emergence of religion (in general) and the morphogenesis of specific religious (and mythical) forms. As a theoretical background, it has recourse to René Thom’s “morpho-dynamics” and “semio-physics”. The contours of a catastrophe-theoretical model of morphogenesis of religions and their possible implosion after a phase of hyper-complexity are described with a focus on polytheistic features of Hinduism and its implosion in the Buddhist “revolution”. A section on Christianism describes the early phases of its self-organization (after the death of Jesus) and its stabilization as a state religion. The basic attractors of this morphogenesis are Jesus and (his mother) Mary. Finally, the further unfolding of religion, its semio- and ratio-genesis, are commented on. The morpho-dynamic modeling of religion avoids traditional, cultural and philosophical biases and raises the highly controversial topic of religion to a scientific level, accessible to mathematical treatment and empirical evaluation.
Almost all entries in the character table of the symmetric group are multiples of any given prime
Authors: Peluse Sarah , Soundararajan Kannan
Published: June 2022

We show that almost every entry in the character table of

S
N

{S_{N}}

is divisible by any fixed prime as

N
→
∞

{N\to\infty}

. This proves a conjecture of Miller.
Long-term follow-up of alkaptonuria patients: single center experience
Authors: Bozaci Ayse Ergul , Yazici Havva , Canda Ebru , Uçar Sema Kalkan , Guvenc Merve Saka , Berdeli Afig , Habif Sara , Coker Mahmut
Published: June 2022

Objectives

Alkaptonuria is a rare autosomal recessive genetic disorder resulting from the deficiency of homogentisate 1,2 dioxygenase (HGD), the third enzyme in the tyrosine degradation pathway. Homogentisic acid produced in excess oxidizes into ochronotic pigment polymer. Accumulation of this pigment in various tissues leads to systemic disease.

Methods

Clinical, laboratory, molecular findings and treatment characteristics of 35 patients followed up in Ege University Pediatric Nutrition, and Metabolism Department with the diagnosis of alkaptonuria were evaluated retrospectively.

Results

Twenty-four males (68.57%) and 11 females (31.42%) with a confirmed diagnosis of alkaptonuria from 32 different families were included in the study. We identified 11 different genetic variants; six of these were novel. c.1033C>T, c.676G>A, c.664G>A, c.731_734del, c.1009G>T, c.859_862delins ATAC were not previously reported in the literature. 24 (68.57%) patients only adhered to a low-protein diet in our study group. Seven (20%) patients initiated a low protein diet and NTBC therapy. Mean urinary HGA decreased by 88.7% with nitisinone. No statistical changes were detected in urinary HGA excretion with the low protein diet group.

Conclusions

In our study, alkaptonuria patients were diagnosed at different ages, from infancy to adulthood, and progressed with other systemic involvement in the follow-up. Since the initial period is asymptomatic, giving potentially effective treatment from an early age is under discussion. Raising disease awareness is very important in reducing disease mortality and morbidity rates.
Aristoteles und die athenischen Liturgien
Authors: Dietze-Mager Gertrud
Published: June 2022

An keiner Stelle in seinen Schriften diskutiert Aristoteles das athenische Liturgiesystem, sondern setzt bei seinen wenigen Informationen dazu dessen Kenntnis voraus. An seiner Kritik der athenischen Liturgien im 4. Jahrhundert als ungerechter Belastung der Reichen läßt er allerdings keinen Zweifel. Welches sind die Gründe für seine Ablehnung, und wie sollten die Liturgien Aristoteles zufolge besser organisiert sein? Wir vergleichen Aristoteles’ Aussagen und Bewertung des Liturgiesystems mit Informationen aus externen Quellen und kommen zu dem Schluß, daß viele seiner Vorstellungen in der Verfassung des Demetrios von Phaleron verwirklicht worden sind. Unsere Diskussion beleuchtet die Entwicklung von der privat finanzierten Liturgie zum öffentlichen Amt sowie die problematische Frage, wie in einer Demokratie die nötigen Eigenmittel zur Erledigung der Aufgaben generiert werden konnten, die zuvor von Liturgen ausgeführt wurden, eine Entwicklung, die zu den von Euergeten finanzierten Amtsliturgien in der hellenistischen Zeit führte.
Some Notes on the Athenian Gymnasiarch
Authors: Fauconnier Bram
Published: June 2022

This paper investigates the Athenian gymnasiarchy, an office that remains badly understood. Originally a festival liturgy, the gymnasiarchy was transformed into a magistracy at the end of the fourth century BC. This paper first examines the reasons for the shift and argues that it was connected to broader political currents in late Classical Athens. Secondly, it sheds new light on the nature of the office in the Hellenistic period. Whereas earlier scholars assumed that the Athenian gymnasiarch was a minor official under thekosmetes, epigraphic and literary sources reveal that he was a fully-fledged gymnasium director, just as in otherpoleis.
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis
Authors: Yang Xiaochun , Liang Xuegang , Guo Haohui , Ma Long , Jian Li , Zhao Xin , Wang Jian , Yang Lvlin , Meng Zhiqiang , Jin Qunhua
Published: June 2022

An important causative factor in osteoarthritis (OA) is the abnormal mechanical stress-induced bone remodeling of the subchondral bone. β2-adrenergic receptor (Adrb2) plays a major role in mechanical stresses that induce bone remodeling. The medial tibial plateau (MTP) and lateral tibial plateau (LTP) of patients with varus Knee osteoarthritis (KO) bear different mechanical stresses. The present study aimed to investigate the expression of Adrb2 in medial tibial plateau subchondral bone (MTPSB) and lateral tibial plateau subchondral bone (LTPSB) in patients with varus KO. A total of 30 tibial plateau samples from patients undergoing total knee arthroplasty for varus KO and MTPSB and LTPSB were studied. Statistical analysis was performed using paired sample t-tests. Safranin O-Fast Green staining and Micro-computed tomography showed significant differences in the bone structure between MTPSB and LTPSB. Tartrate-resistant acid phosphatase (TRAP)-positive cell density in MTPSB was higher than that in LTPSB. Immunohistochemistry, reverse transcription-quantitative polymerase chain reaction, and Western blot analysis revealed that compared to LTPSB, the levels of Adrb2, tyrosine hydroxylase (TH), and osteocalcin increased significantly in MTPSB. Double-labeling immunofluorescence showed Adrb2 was present in the majority of TRAP-positive multinuclear cells of the MTPSB. The expression of Adrb2 and TH was significantly higher in MTPSB than in LTPSB, confirming the involvement of these molecules in the development of OA.
Let-7i-3p inhibits the cell cycle, proliferation, invasion, and migration of colorectal cancer cells via downregulating CCND1
Authors: Tu Fei , Li Mengfan , Chen Yinyu , Chu Huiru , Wang Shujie , Hai Lun , Xie Ting , Geng Fangfang , Zhao Tiesuo , Wang Qingzhi , Feng Zhiwei
Published: June 2022

Dysregulated microRNAs are closely related to the malignant progression of colorectal cancer (CRC). Although abnormal let-7i-3p expression has been reported in various human cancers, its biological role and potential mechanism in CRC remain unclear. Therefore, the purpose of this study was to investigate the expression and regulation of let-7i-3p in CRC. Here, we demonstrated that let-7i-3p expression was significantly downregulated in three CRC cell lines while CyclinD1 (CCND1) was upregulated compared with the normal colon epithelial FHC cells. Moreover, bioinformatics and luciferase reporter assays revealed that CCND1 was a direct functional target of let-7i-3p. In addition, let-7i-3p overexpression or CCND1 silencing inhibited cell cycle, proliferation, invasion, and migration and diminished the activation of p-ERK in HCT116 cells. However, exogenously expressing CCND1 alleviated these effects. Taken together, our findings may provide new insight into the pathogenesis of CRC and let-7i-3p/CCND1 might function as new therapeutic targets for CRC.
Effect of heat-treatment on crash performance in bumper beam and crash box design and optimization of the system
Authors: Öztürk İsmail , Kaya Burak Sercan
Published: June 2022

Within the study’s scope, impact analyses of homogeneous bumper beam-crash box systems designed from AA6063-O, AA6063-T5, and AA6063-T6 materials and hybrid systems designed from combinations of these materials were made and compared in terms of energy absorption values. In designs where failure does not occur, the highest energy absorption value was obtained using the AA6063-T5 bumper beam and AA6063-O crash box system, and single and multi-objective optimization studies were conducted using this design. The optimal bumper system improved the crash performance of the structure. Accordingly, this bumper system can be used in vehicles to improve crashworthiness.
Numerical analysis of bent aluminium sandwich panels with different tubular cores
Authors: Eksi Seçil
Published: June 2022

Sandwich panels are frequently used in transportation, automotive, aerospace and marine sectors due to their high rigidity, strength and ability to absorb energy. In this study, finite element analyses investigated the bending behaviour of aluminium sandwich panels fixed at both ends with different geometrical tubular core structures. The sandwich panels consist of 6063-T5 Aluminium core and 7075-T6 Aluminium skin. The core structure used square, circle, triangle, honeycomb, vertical ellipse and horizontal ellipse tube geometries. The square tube-core sandwich panel has the highest specific load-carrying capacity (SLCC) among the different tube-core geometries. In the square tube-core sandwich panel, where the number of tubes varies, the seven-tube-core panel showed the highest SLCC.
High-sensitive and disposable myocardial infarction biomarker immunosensor with optofluidic microtubule lasing
Authors: Niu Panpan , Jiang Junfeng , Liu Kun , Wang Shuang , Wang Tong , Liu Yize , Zhang Xuezhi , Ding Zhenyang , Liu Tiegen
Published: June 2022

The early diagnosis of myocardial infarction can significantly improve the survival rate in emergency treatment, which is mainly implemented by the immunoassay for myocardial infarction biomarkers such as cardiac troponins in blood. In this work, a disposable optofluidic microtubule whispering gallery mode (WGM) immunosensor for label-free cardiac troponin I-C (cTnI-C) complex detection has been proposed and demonstrated with active interrogation enhancement. The disposable microtubule is simply fabricated by a silica capillary with pressurized tapering technology for thin-wall, and the cTnI antibodies are immobilized on the inner wall surface of the microtubule through the self-adherent polydopamine substrate. By configuring the two coupling microfibers, the double-fiber-coupled microtubule cavity can serve as a tunable filter for the mutual-coupled polarimetric fiber ring laser (FRL), whose output laser wavelength is determined by the cTnI-C concentration in the optofluidic microtubule with inherent microfluidic channel. Due to the cyclic-cumulative gain of the FRL, the characteristic resonant peak of optical sensing signal is enhanced in the spectral width compression and the optical signal-to-noise ratio improvement, and therefore the optical immunosensor for cTnI-C can be achieved by tracking the output laser wavelength of the FRL conveniently. The dynamic binding and unbinding process of cTnI-C antigen–antibody is illustrated by monitoring the lasing peak wavelength continuously. Our all-fiber immunosensor demonstrated here has the advantages of fast label-free detection, real-time monitor, high sensitivity and disposable sensing element, which can be an innovative detecting tool in early diagnosis of myocardial infarction.
The Witching Body: Ontology and Physicality of the Witch
Authors: Devereux Katherine R.
Published: June 2022

These considerations illuminate an ontology of the witch by first disclosing how “witch,” as a linguistic gesture, carries a world of meaning, ethics, and a culture of being originating in the body. Witches and witchcraft speak to a communal situatedness of being by acknowledging the power we have over ourselves, others, and that singular lack of control we often experience in everyday life. In dialogue with Ada Agada, Emmanuel Lévinas, and Maurice Merleau-Ponty, I offer an interpretation of the body schema through what I call the “witching-body,” drawing on historical and anthropological examples of witchcraft as related to personhood, thus demonstrating how embodiment philosophy and ontology are already alive in everyday ritual and magical acts. I explain the other’s contradiction of everydayness and transcendence through the reflexivity of self-sensing-self and how aspects of our own body, such as organs and emotions, may be occult or other to us. The everydayness of witchcraft and the ungraspable ambiguity of the witch speak to this necessary transcendence we experience with everyday others; there is both a banality and an infinite plurality. We yearn to know the witch because through the embodied existential expressions of “witch” we find what constitutes being a person.
Of Coase, Cattle, and Crime: Why the Becker Model is Compatible with a Moral Theory of Criminal Law
Authors: Miceli Thomas J.
Published: June 2022

The economic model of crime is often portrayed (and criticized) as being contrary to a moral theory of criminal law. This paper advances the opposing view that the two theories are in fact potentially compatible with one another. The basis for this claim is that, whereas the Becker (1968. Crime and punishment: an economic approach. J. Polit. Econ. 76: 169–217) model is useful in prescribing a theory of optimal enforcement of the law, it does not, and indeed cannot, provide a definitive prescription for its content. The reason is the reciprocal nature of harm in situations involving incompatible rights, a principle first identified by Coase (1960. The problem of social cost. J. Law Econ. 3: 1–44) in the general context of externalities. The paper develops this argument, offers a formal demonstration of it, and draws out some of its implications.
A threshold model for the spread
Authors: Hatzinikolaou Dimitris , Sarigiannidis Georgios
Published: June 2022

Using annual data from two panels, one of 11 Eurozone countries and another of 31 OECD countries, we estimate a two-regime log-linear as well as a nonlinear model for the spread as a function of macroeconomic and quality-of-institutions variables. The two regimes, a high-spread and a low-spread regime, are distinguished by using a threshold, in accordance with the perceived “fair” value of the spread as a reference point. Our results suggest that government-bond spreads are regime-dependent, as most of the regression coefficients of the determinants of the spread are larger (in absolute value) in the high-spread regime than in the low-spread regime. That is, an improvement in the macroeconomic environment (e.g., lower unemployment, lower inflation, lower growth of the debt-to-GDP ratio, less macroeconomic uncertainty, higher growth of real GDP), and/or an improvement in the quality of institutions (e.g., less corruption) reduce the spread facing a country (by enhancing its creditworthiness) to a greater extent in high-spread situations than in low-spread situations. A possible explanation is that the demand for and the supply of loans are inelastic at higher than “fair” interest rates and elastic at lower rates.
Quantitative assessment of a beam hole scatter correction in industrial computed tomography
Authors: Kaufmann Manuel , Pfaffelhuber Carla , Vater Ingo , Wiest Wolfram , Höhe Hendrik , Effenberger Ira
Published: June 2022

In industrial Computed Tomography (CT), scattered radiation causes a loss of quality of the reconstructed 3D volume. Scatter is caused by photon-matter interaction, whereby a photon is deflected from its initial propagation direction. The most prominent contributor to scattered radiation in the scope of photon energies occurring in industrial CT is Compton Scattering. With the used Beam Hole Array (BHA) technology for scatter correction, scatter intensities are determined by subtracting the primary intensities, which are gathered behind small apertures from the total intensities, which are gathered in the absence of the apertures. Intensities measured behind the apertures are assumed to be scatter free, since the transversal components of the radiation are strongly reduced. The scatter correction is performed by subtracting scatter intensities from primary intensities in the projection image. Improvements are evaluated for a newly developed test specimen considering image quality metrics and dimensional accuracy. The contrast could be improved especially for small structures. Cupping artifacts that express as systematic offset of grey values rising with the penetration length were reduced. Measurement deviations towards tactile references were decreased.
Experimentelle Untersuchung des Betriebsverhaltens von Planetenrollengewindetrieben
Authors: Brecher Christian , Axelrad Gabriel , Neus Stephan
Published: June 2022

Für Anwendungen, in denen Linearaktoren mit besonders hohen Tragfähigkeiten und sehr großen Kraftübersetzungen benötigt werden, können neuartige Planetenrollengewindetriebe (PRGT) mit unterschiedlichen Gewindegangzahlen von Spindel und Mutter eingesetzt werden. Das Betriebsverhalten dieser Komponenten weicht von marktverfügbaren Standard-PRGT ab und ist insbesondere im Bereich hoher Axiallasten weitgehend unerforscht. Im vorliegenden Beitrag werden daher Versuche auf einem am Werkzeugmaschinenlabor WZL der RWTH Aachen entwickelten Hochlastprüfstand beschrieben, anhand derer das Betriebsverhalten hinsichtlich Steigung, Wirkungsgrad und Steifigkeit untersucht werden kann.
Intuitives Bedienkonzept für Gabelstapler
Authors: Feiner Leonhard , Geisel Viktoria , Fottner Johannes
Published: June 2022

Bisher werden Gabelstapler durch herstellerspezifische Bedienkonzepte gesteuert. Vor allem für unerfahrene Mitarbeiter sind diese nicht intuitiv nutzbar. Ein neuartiges Bedienkonzept, bei dem die Bewegungsachsen des Bedienelements und der Maschine übereinstimmen, soll dies verbessern. Eine Probandenstudie konnte zeigen, dass dadurch insbesondere bei wenig erfahrenen Benutzern eine Reduzierung der Bedienfehler sowie eine Erhöhung der Gebrauchstauglichkeit und Intuitivität erreicht werden können.
Fabrikplanung 5.0 in und mit Virtual Reality
Authors: Schlegel Marc , Bracht Uwe
Published: June 2022

Menschen sind von Natur aus auf die Orientierung im dreidimensionalen Raum eingerichtet. Sie denken und leben dreidimensional; deshalb ist es ein unersetzbarer Vorteil, bereits die Planung und Gestaltung von Fabriken sowie deren laufende Optimierung dreidimensional durchführen zu können. Im folgenden Beitrag wird eine bahnbrechende, detaillierte Gesamtmethodik vorgestellt, die umfassend den Layoutplanungsprozess über alle Planungsebenen hinweg in die Virtuelle Realität transferiert. Mehrere praktische Anwendungsbeispiele dokumentieren die grundlegende Innovation und zeigen die großen Nutzenpotenziale auf.
Differential Responsiveness for Strength Gain Between Limbs After Resistance Training in Older Women: Impact on Interlimb Asymmetry Reduction
Authors: Nunes João Pedro , Marcori Alexandre J. , Ribeiro Alex S. , Cunha Paolo M. , Kassiano Witalo , Costa Bruna D.V. , Aguiar Andreo F. , Nakamura Masatoshi , Mayhew Jerry L. , Cyrino Edilson S.
Published: June 2022

Nunes, JP, Marcori, AJ, Ribeiro, AS, Cunha, PM, Kassiano, W, Costa, BDV, Aguiar, AF, Nakamura, M, Mayhew, JL, and Cyrino, ES. Differential responsiveness for strength gain between limbs after resistance training in older women: Impact on interlimb asymmetry reduction. J Strength Cond Res 36(11): 3209–3216, 2022—The present study compared strength responses between preferred (PREF) and nonpreferred (N-PREF) legs in older women. Muscular strength was measured unilaterally using an isokinetic dynamometer and was analyzed for reproducibility scores, acute performance, and responsiveness to a resistance training (RT) program. One hundred eleven women (aged ≥60 years) performed 12 weeks of whole-body RT (3 times a week; 4 lower-body exercises). Reproducibility scores (intraclass correlation coefficient ≥0.920; following test-retests in part of the sample at pretraining; n = 19), average acute performances, and average strength gains (PREF = ∼6.9%; N-PREF = ∼7.2%) were similar between legs (p > 0.05). However, the individual analyses showed that some subjects were considered responders to strength gains in 1 leg, whereas nonresponders in the other. Nonetheless, when considering the responses in all strength tests, most subjects (91%) were considered responder to at least 1 measure. In addition, it was observed that the strength ratio between PREF/N-PREF legs was altered for those who presented some asymmetry at baseline, as the limbs became more symmetrical in all strength measures after the RT. In conclusion, we observed that some older women may have different levels of strength between legs; however, a traditional 12-week RT program with bilateral exercises can reduce such asymmetry by inducing greater strength gains in the weaker leg.
No Effect of Interset Palm Cooling on Acute Bench Press Performance, Electromyography Amplitude, or Spectral Frequencies in Resistance-Trained Men
Authors: McMahon Gerard , Kennedy Rodney , Burden Adrian
Published: June 2022

McMahon, G, Kennedy, R, and Burden, A. No effect of interset palm cooling on acute bench press performance, electromyography amplitude or spectral frequencies in resistance-trained men. J Strength Cond Res 37(3): 555–563, 2023—Previous research has suggested that cooling distal to the working agonist muscles during the interset rest periods of high-intensity resistance exercise may facilitate improved performance through increased agonist activation. However, these studies have used inappropriate electromyography (EMG) normalization techniques. Therefore, the aim of this study was to compare 2 palm-cooling conditions with a thermoneutral condition during high-intensity resistance exercise and subsequent effects on exercise performance, EMG amplitude, and spectral frequencies using appropriate normalization methodologies. Eleven healthy, resistance-trained, young men (20–36 years old) performed 4 sets of bench press exercise to exhaustion at 80% 1RM each separated by 3 minutes of passive recovery. Palm-cooling (10° C [TEN] or 15° C [FTN]) or thermoneutral (28° C [CON]) conditions were applied for 60 seconds during the recovery interval of each set in a randomized, double-blind fashion, with 4 days of recovery between experimental conditions. Palm temperature was significantly lower (p < 0.05) in the TEN and FTN conditions compared with CON. Number of repetitions and mean power in the bench press declined significantly after each set in all conditions (p < 0.05). There were no significant differences (p > 0.05) in any bench press performance or EMG-related variables between any of the conditions. Palm cooling at either 10 or 15° C had no effects on bench press performance compared with a thermoneutral condition, with no observable effects on neuromuscular responses during exercise. Therefore, cooling is not currently recommended as an ergogenic strategy to enhance acute bench press performance during high-intensity resistance training.
Validity of Bioelectric Impedance in Relation to Dual-Energy X-Ray Absorptiometry for Measuring Baseline and Change in Body Composition After an Exercise Program in Stroke
Authors: Vanzella Lais M. , Lawand Robert , Shuaib Marya , Oh Paul , Corbett Dale , Marzolini Susan
Published: June 2022

Vanzella, LM, Lawand, R, Shuaib, M, Oh, P, Corbett, D, and Marzolini, S. Validity of bioelectric impedance in relation to dual-energy x-ray absorptiometry for measuring baseline and change in body composition after an exercise program in stroke. J Strength Cond Res 36(12): 3273–3279, 2022—Exercise is an important strategy to improve fat-free mass (FFM) and reduce percent fat mass (FM%). However, no study has reported on a valid, cost-effective method to measure changes in body composition after stroke. The purpose of the study is to determine the level of agreement between bioelectrical impedance analysis (BIA) and dual-energy x-ray absorptiometry (DXA) for assessing baseline and change in FFM and FM% after an exercise training intervention for individuals with mobility deficits after stroke. Fat-free mass and FM% were measured by BIA and DXA at the beginning and after 6 months of participation in an exercise program for individuals with mobility deficits after stroke. Forty-two subjects after stroke were included. Overall, Bland-Altman plots revealed that BIA overestimated the baseline FFM and FM% by only −0.4 ± 1.8 kg and −2.8 ± 1.8%, respectively. BIA underestimated changes in FFM by 0.33 ± 0.45 kg and overestimated changes in FM% by −0.40 ± 0.68%. The 95% CI of the mean bias for baseline FFM was −7.1 to 6.3 kg and −11.8 to 6.0% for FM%, demonstrating good agreement. The 95% CI for the change in FFM was −3.8 to 4.5 kg and −5.0 to 4.2% for FM%, which reflected good agreement. BIA is a good tool for assessing qualitative baseline and change in FFM and FM%. Body composition is important for the prescription and evaluation of rehabilitation programs designed for individuals after stroke. Our results provide clinicians and researchers with a better understanding of the utility of BIA to measure body composition at baseline and in response to exercise interventions in this population.