bluuebunny/crossref_metadata_2025 huggingface dataset:
La práctica profesional de los Departamentos de Consejería Estudiantil (DECE) en Guayaquil
Authors:   UEES-Universidad Espíritu Santo Guayaquil-Ecuador, Manzo-Montesdeoca Ángel , Sigüencia Vivar Dolores ,   Ministerio de Educación del Ecuador, Quito-Ecuador, Soria Castro Eliana ,   Independiente, Guayaquil-Ecuador, Pozo Pachar Valeria ,   Universidad Tecnológica ECOTEC, Guayaquil-Ecuador
Published: February 2025

La relación entre psicología y epistemología fue descrita en su momento como“epistemológicamente atormentada, monstruosa y bicéfala” (Blanco, 2002) a partir de la complejidad tanto de su origen histórico, objetivo de estudio y la subjetividad que implica toda intervención humana.
Terapia sistémica: una visión desde lo dialéctico y transgeneracional
Authors:   Pontificia Universidad Católica, Quito-Ecuador, Ortiz Granja Dorys
Published: February 2025

La reflexión que se propone en este texto se plantea desde la perspectiva sistémica e integra aspectos clave para comprender lo que sucede en alguien que experimenta un sufrimiento. Su sanación implica, tanto la revisión del síntoma en sí mismo como también en su sistema de origen y afecta, finalmente, la construcción identitaria que la persona.
La integración religiosa como factor de protección al comportamiento suicida. Una comprensión hermenéutica desde E. Durkheim
Authors:   Universidad Católica Luis Amigó. Medellín-Colombia, Amador Sánchez Omar , Quintero Arango Luis ,   Universidad Católica Luis Amigó. Medellín-Colombia
Published: February 2025

De acuerdo con la Organización Mundial de la Salud (OMS, 2019), el suicidio es un acto deliberado a través del cual el sujeto desea quitarse la vida, y con base en resultados epidemiológicos, a partir de los años 70 se considera como un problema de salud pública mundial. La OMS reporta a 2019, que la tasa de crecimiento es superior al 20 % anual, calculando que diariamente, más de 9000 personas intentan quitarse la vida. Al año, los datos reportados se acercan al millón de casos, y sugiere que cada 40 segundos hay una muerte por mano propia en algún lugar de la tierra.
Metaverso y neuromarketing:innovación metodológica en el estudio del consumidor y del retail
Authors: Crespo-Pereira Verónica , Sánchez-Amboage Eva
Published: February 2025

Neurotechnologies lead to the study of the nervous system and to improve its function. They are supposed to become one of the great technological leaps of our days. Traditionally they have been used in the field of health, however, their universalization, by operability and cost, has promoted their use in different areas within the social sciences through the discipline called neuromarketing or consumer neuroscience to apply it in market research. The appearance of metaverse could incorporate new formulas for the study of individuals and audiences due to the wide range of neurophysiological recording sensors (eye tracking, EEG, EDA ...) incorporated in the hardware of virtual reality and augmented reality. This paper focuses on the potential of the technologies in the context of metaverse for market research and the creation of innovative metrics of interest for business, communicational, advertising and educational fields. To portray this situation, a literature review, a documentary analysis and interviews with experts in cognitive neuroscience, artificial intelligence (AI) and neuroarchitecture are carried out. Although the results demonstrate the existence of neurophysiological sensors in metaverse devices and the possibility of conducting neurophysiological research in real consumer environments, technological obstacles and basic scientific knowledge must be overcome.
Instagram como herramienta digital para la comunicación y posicionamiento de marcas de moda: estudio de caso en Ecuador
Authors: León-Alberca Tatiana , Calva-Cabrera Daniela , Renés-Arellano Paula , Inzunza-Acedo Beatriz
Published: February 2025

The present study examines Instagram as a strategic tool for communication and brand positioning in the fashion industry, focusing on the accounts of Ropa Gallardo and Afrikana. This research is justifiedby the rise of digital marketing and the need to design effective strategies on visual platforms like Instagram,which have redefined interactions between brands and audiences. The objectives are to analyzethe communication strategies implemented, identify the most effective tactics, and evaluate the impact of these actions on market positioning. The adopted methodology is mixed, combining quantitative and qualitative analyses. Over 2,400 posts from both brands between 2023 and 2024 were examined, analyzing variables such as content formats, posting frequency, hashtag usage, and interaction rates. The analysis focused on identifying engagement patterns and the effectiveness of the implemented strategies. Among the findings, Afrikana stood out for achieving higher engagement proportional to its follower base, driven by the use of formats such as Reels and personal narratives. Ropa Gallardo, despite having a larger number of followers and posts, showed a lower interaction rate. Afrikana recorded a 67,6%increase in its follower base, while Ropa Gallardo grew by 5,6%. The study concludes that the use ofemotional narratives, storytelling, and collaborations with influencers are essential to enhancing engagementand brand positioning.
Slide-Tags using Tissue-Tape v1
Authors: Nadaf Naeem , Rayan Nirmala
Published: February 2025

Slide-tags is a method that involves tagging cellular nuclei from intact fresh frozen tissue sections with spatial barcode oligonucleotides derived from DNA-barcoded beads positioned at known locations. These tagged nuclei are then analyzed using existing single-cell methods, enhanced with spatial positioning information (Nature 625, 101–109 (2024)). The traditional method of placing tissues onto DNA-barcoded pucks can be time-consuming and labor-intensive. This protocol integrates the tape transfer technique for mounting tissues (PLoS One. 2015 Jul 16;10(7)) with Slide-tags. The tape transfer technique allows tissues to be placed on barcoded pucks for Slide-tags, enhancing spatial placement accuracy while preserving the structural integrity of the tissue, and reducing the required time by half. The size of the tape can be chosen and adjusted to accommodate the tissue area. The barcoded single nuclei obtained through this workflow seamlessly integrate with 10x GEM generation, gene expression, and spatial barcode library generation.
Protocol for pollen and dinocyst analysis in marine sediments v1
Authors: Geoget Muriel , Castéra Marie-Hélène , Ludovic DEVAUX , Turon Jean-Louis , Stéphanie Desprat , F. Sanchez Goñi Maria
Published: February 2025

The protocol is dedicated to the preparation of sediment samples from marine cores to analyse pollen and dinocyts.
Subjectivation of Meanings in Perceptions of Adulthood among Young Men and Women
Authors: Shilova N.P.
Published: February 2025

The paper presents research materials that demonstrate the features of subjectivation of meanings in the perceptions of young men and women, based on their interpretation of artistic representations of adulthood. The study aimed to identify the characteristics of subjectivation of meanings in young people’s perceptions as an indicator of their maturation. The research involved a sample of 321 individuals 14–23 years old (M=18, SD=2.88) and utilized an original projective methodology ("Adulthood"), distinguishing it from conventional self-assessment questionnaires. Data analysis included Pearson’s chi-square contingency tables, cluster analysis, and clustering quality assessment via the Rand index. The results highlight that the maturation of young men and women in the modern world is a heterochronous process. By analyzing artistic depictions of adulthood in the classic film “The Prank” (1977) and the contemporary film “Sasha’s Country” (2022), three types of subjectivation of adulthood were identified. The study emphasizes the applicability of these typologies in educational practice and their relevance for educators and psychologists working with adolescents and young adults in life and career guidance programs.
Smartphone Addiction, Religiosity, and Academic Procrastination among College Students: the Mediating Role of Self-Esteem and Self-Regulated Learning
Authors: Sujadi E. , Sulistiyo U.
Published: February 2025

Academic procrastination is a prevalent issue among college students. This study aims to investigate the correlation between smartphone addiction, religiosity, and academic procrastination by considering the mediating role of self-esteem and self-regulated learning (SRL). The Procrastination Scale, Religiosity among Muslim scale, Smartphone Addiction Scale-Short Version (SAS-SV), Rosenberg Self-Esteem Scale (RSE), and Academic Self-Regulated Learning Scale (A-SRL) were administered to 512 Muslim college students (42,19% males and 57,81% females; mean age=19,72, SD=1,36). The hypotheses were evaluated using Partial Least Squares (PLS) modeling. The results revealed that smartphone addiction, religiosity, self-esteem, and SRL were significantly correlated with academic procrastination. The structural equation model revealed that self-esteem and SRL mediated the correlation between religiosity and academic procrastination. In terms of the correlation between smartphone addiction and academic procrastination, only SRL acted as a mediator, while self-esteem did not. The findings are valuable for counselors and college educators, offering insights into the connections among smartphone addiction, religiosity, and academic procrastination. This knowledge can provide practical guidance for preventing and addressing academic procrastination issues in college students effectively.
Academic Adjustments for First-Year Students: Influence Factors and Measurement
Authors: Lubis H. , Atmoko A. , Rahmawati H. , Setiyowati N. , Alfath E.A. , Razak M.
Published: February 2025

The transition from high school to the college stage is a period that students must pass. During the transition period, students who have turned into college students will face various changes in the learning process, demands, conflict problems, and new personalities in college life, which can cause stress and mental health problems. In dealing with these changes, reasonable academic adjustment, support from family and friends, and effective coping strategies are needed so that they can get through this transition period successfully and enjoy new experiences as students in college. Research on academic adjustment has been done before, so researchers are interested in conducting a theoretical study on the factors that influence academic adjustment, especially in first-year students. This research uses a literature study method by analyzing thirty research articles related to student academic adjustment. Based on the analysis results, it can be seen that the factors that affect the academic adjustment of first-year students are 1) demographic factors; 2) psychological factors; 3) environmental factors. Currently, academic adjustment can be measured using self-report questionnaires that have been developed, such as the College Inventory of Academic Adjustment, Student Adaptation to College Questionnaire (SACQ), Academic Adjustment Questionnaire (AAQ), and College Adaptation Scale (CAS).
Correlation of Academic Cyberloafing and Cyberbullying
Authors: Sivrikova N.V. , Tatiana T.G. , Perebeinos A.E.
Published: February 2025

The article presents the results of a study examining the correlation between two forms of deviant behavior associated with the use of virtual space: Cyberloafing and cyberbullying. This phenomena was considerated within the educational context. The research is based on empirical data collected from from schoolchildren and students in Chelyabinsk. 128 schoolchildren aged 14 to 18 years and 216 students aged 17 to 22 years were recruited for this study. The study methods were an Adapted Cyberloafing Scale (developed by N.V. Sivrikova), and a School Bullying Questionnaire (designed by M.A. Novikova, A.A. Rean, and I.A. Konovalov). The results of the study showed, that among the factors causing Internet-related deviations (cyberloafing and cyberbullying) are the level of education, gender, and restrictions on the use of phones within educational institutions. The research established a link between the structures of cyberbullying and cyberloafing. Game-related cyberloafing was found to be associated only with the role of a witness. In contrast, other types of cyberloafing showed a correlation with the degree of involvement in all three roles examined in cyberbullying: victim, aggressor, and witness. Overall, the findings partially validate the model of problematic information technology use proposed by F. Jabeen, A. Tandon, and others.
A arte dos (des)encontros inscrita no jogo ambivalente novo/velho: a mediação de conflitos como percurso emancipatório à condição humana
Authors: Dutra Gabrielle Scola , Gimenez Charlise Paula Colet , Martini Sandra Regina
Published: February 2025

A temática da pesquisa é a mediação de conflitos. O objetivo geral é abordar a mediação de conflitos pelo dueto entre Eligio Resta e Luis Alberto Warat. Os objetivos específicos são: 1) Apresentar a mediação de conflitos através da Metateoria do Direito Fraterno do jurista italiano Eligio Resta; 2) Estudar a mediação de conflitos como resposta ecológica na perspectiva de Luis Alberto Warat. O estudo se arquiteta pelo método hipotético-dedutivo e instruído por uma análise bibliográfica. Diante da arte dos (des)encontros inscrita no jogo ambivalente novo/velho, questiona-se: a mediação de conflitos é uma possibilidade de promover um percurso emancipatório à condição humana? Constata-se que a mediação de conflitos é uma possibilidade de promover um percurso emancipatório à condição humana na dimensão fraterna, sensível e ecológica de tratamento de conflitos.
O sistema de processo judicial eletrônico e dificuldades das equipes de suporte envolvendo a gestão do conhecimento
Authors: Sousa José Francisco Brandão de , Caselli Francisco de Tarso Ribeiro
Published: February 2025

O objetivo deste artigo é investigar as dificuldades enfrentadas no processo de construção do conhecimento sobre o Sistema de Processo Judicial Eletrônico (PJe), um sistema de processamento de informações e prática de atos processuais, com o intuito de facilitar e otimizar os serviços administrativos, aumentando sua eficiência e transparência. Para embasar teoricamente o tema investigado, foi utilizada uma metodologia quali-quantitativa, complementada por uma pesquisa bibliográfica. A pesquisa busca obter dados relacionados ao tempo estimado e ao nível de compreensão que os profissionais de Tecnologia da Informação (TI), envolvidos com o suporte ao sistema, necessitaram para entender determinadas funcionalidades apresentadas pelo PJe. Este trabalho se propõe a evidenciar o objetivo da pesquisa ao coletar e analisar informações sobre as experiências desses profissionais. Os resultados demonstram um cenário caracterizado pela falta de uma eficiente implementação da Gestão do Conhecimento em torno do sistema.
Investigação criminal defensiva como solução democrática ao lawfare
Authors: Araújo Leonardo de Lara , Santin Valter Foletto , Cardoso Henrique Ribeiro
Published: February 2025

O presente trabalho busca demonstrar a influência negativa da prática de lawfare para a democracia e que o mau uso das leis e do processo penal para fins políticos demanda a aplicação de um instrumento processual penal que visa garantir os direitos do acusado e a manutenção do Estado Democrático de Direito. Neste sentido, o instituto da investigação criminal defensiva surge como meio de investigação preliminar própria da defesa a fim de dar efetividade ao princípio da ampla defesa e atuar como mecanismo auxiliar na solução democrática ao autoritarismo da prática de lawfare. A pesquisa se utiliza do método de abordagem hipotético-dedutivo, através da análise do direito comparado e, principalmente, da pesquisa bibliográfica, em livros, revistas eletrônicas e legislação.
Purgação da mora nos contratos de alienação fiduciária de bens móveis à luz do direito do consumidor: uma análise do decreto-lei n° 911/1969
Authors: Cardoso Carlos Henrique Baptista , Oliveira Emerson Ademir Borges de
Published: February 2025

O presente trabalho tem como objetivo estudar os contratos de alienação fiduciária no tocante aos bens móveis perante o Código de Defesa do Consumidor, bem como analisar os princípios do negócio jurídico externados pelo Código Civil. Nessa esteira, analisar-se-ão questões como a purgação da mora nos contratos de alienação, perante o entendimento do Superior Tribunal de Justiça, e aplicabilidade do adimplemento substancial que decorre dos princípios gerais contratuais, tal qual a consonância desta teoria com a sistemática contida na legislação consumerista e constitucional, como mecanismo de coibir a onerosidade excessiva em face do consumidor. Para tanto, foi utilizado o método dedutivo, valendo-se da análise doutrinária, legislação nacional, assim como o exame documental de fatores históricos, políticos e jurídicos. Ademais, a pesquisa realizada tem relevância para a sociedade, tanto do ponto de vista econômico como social, pelo fato de que as aspirações do mercado financeiro podem ser conciliadas à luz do Direito do Consumidor, na busca pela ponderação do sistema.
CALCIFICATING EPITHELIOMA OF MALHERBE: CLINICAL CASE
Authors: Vatina Liana , Isaev Pavel A. , Polkin Viatcheslav , Ilyin Alexei , Yakusheva Anastasiya , Ryzhenkova Maria Igorevna , Ivanov Sergei , Kaprin Andrei D.
Published: February 2025

BACKGROUND: The aim is to present a case of calcificating epithelioma of Malherbe (CEM) in the shoulder area in a 7-year-old female through retrospective review of medical records of a single patient.
CLINICAL CASE DESCRIPTION: A 7-year-old female developed a lesion In the distal part of the right shoulder. On examinationval, subcutaneous tumor measuring up to 2 sm was found . It gave bluish tint under the firmly adherent overlying skin of normal color and texture. Rocky hard and non-tender, it was mobile over the underlying tissues. Total excision biopsy was performed under general anesthesia. Histopathologic analysis confirmed the diagnosis of CEM.
CONCLUSION: CEM is a rare tumor with head, neck. It is often clinically misdiagnosed and/or missed on differential diagnosis. Total surgical excision of the mass is recommended. For children, when families desire greater preoperative certainty, additional diagnostic procedures may be useful.
The 2023 Mw 6.0 Jishishan Earthquake: A Slow Unilateral Rupture on a Blind Thrust Fault Revealed by High-Precision Earthquake Locations and Dynamic Modeling
Authors: Zhang Long , He Zhongqiu , Wang Shiguang , Zhang Yong , Li Shuai , Zhang Zhenguo , Fang Lihua
Published: February 2025

The 18 December 2023 Mw 6.0 Jishishan earthquake struck the Dahejia basin in the northeastern Tibetan Plateau. Three isolated sites of concentrated fractures with a total length of ∼8 km were observed in field surveys. It remains unclear that such surface faulting was the extension of mapped active thrusts or just ground cracking. Moreover, inaccurate and incomplete routine earthquake catalog based on a sparse permanent seismic network makes it difficult to determine the seismogenic fault within a multifault zone. In this study, we develop a high precision aftershock catalog based on a self-deployed dense seismic array, illuminating an unrecognized blind northeast-dipping seismogenic fault and an activated southwest-dipping conjugate fault. We simulate the dynamic rupture process to investigate slip behaviors and delineate the previously suspected ruptures are ground cracking. Our results present a unilateral rupture event with a relatively slow rupture velocity and low radiation efficiency, suggesting that this earthquake may have ruptured an immature basin thrust.
Global Detection Capabilities of T Phases Using the IMS Hydrophone Network
Authors: Oliveira Tiago C. A. , Prior Mark , Saragiotis Christos , Park Jung Ho , Metz Dirk , Bittner Paulina , Qorbani Ehsan , Khukhuudei Urtnasan , Pérez-Campos Xyoli
Published: February 2025

In addition to monitoring the oceans for signs of nuclear explosions, data from the hydroacoustic component of the International Monitoring System (IMS) have been used for a broad range of civil and scientific applications. This includes studying T phases: seismic waves that convert to underwater acoustic energy at the bottom of the ocean and can travel with low attenuation in the ocean’s Sound Fixing and Ranging channel. This study analyzes T phases recorded from 2001 to 2024 at the six IMS hydrophone stations. Analysis reveals global ocean coverage and demonstrates the network’s ability to detect T phases primarily linked to submarine earthquakes concentrated along tectonic plate boundaries, particularly midocean ridges and transform faults. Notably, some T phases were recorded after propagating more than 20,000 km, exceeding the antipodal range. Results highlight the network’s significant contribution to our understanding of global ocean seismicity. A discussion is provided on earthquake events that led to major detection peaks of T phases in analyst-reviewed bulletins. Finally, it is shown that while T phase detection itself is not network dependent, associating them with events relies on IMS seismic network sensitivity for building the events.
relaciones entre León y Toledo (910-932)
Authors: Carriedo Tejedo Manuel
Published: February 2025

Estudio que analiza la secular trayectoria rebelde de la antigua capital de los godos, Toledo, durante los siglos VIII y IX, y las relaciones político-militares de sus dirigentes con los neogóticos reyes de la "Gallaccia" (con capitales respectivas en Oviedo y León) durante el primer tercio del siglo X a través de los testimonios recogidos en las crónicas musulmanas y en los documentos latinos, donde aparecen citados por este mismo tiempo varios personajes de posible procedencia toledana, entre los cuales Lup iben Alcutia, a quien cabe identificar con cabecilla toledano Lope b. Tarbisa.
Dipeptidyl peptidase 4 levels as a novel potential early marker in the identification of complicated appendicitis
Authors: Saucedo Zamora Brandol D. , García Chávez Luis E. , Torres Montelongo Ivan A. , Araiza Martínez Carlos A. , Valencia Sánchez Liliana D. , Medina Moreno Ursula F.
Published: February 2025

Background: Appendicitis represents one of the most prevalent indications for emergency department care due to abdominal pain. Complications risk depends on how soon are diagnosed. Test like c-reactive protein (CRP) and neutrophil-lymphocyte index (NLI) can assist in diagnose complications, but they are not always precise. Dipeptidyl peptidase 4 (DPP4) has been employed as a new marker in other inflammatory pathologies; thus, exist the potential for its use in pathologies such as appendicitis. Evaluate the utility of serum levels of DPP4, CRP and INL in identify and differentiate complications in patients with histopathologically confirmed appendicitis.
Methods: A cohort study with diagnostic test analysis included patients aged 18-80 years with suspected appendicitis undergoing surgery. They had given informed consent to participate. A minimum of 30 subjects per group was considered. Complicated and uncomplicated appendicitis was diagnosed by histological examination of tissue samples. Sensitivity and specificity of DPP4, CRP levels and NL index in diagnosis of complicated appendicitis were determined.
Results: We observed higher levels of DPP4 (7820 vs 5250 pg/dl,) and CRP (4 vs 10 mg/dl) in complicated appendicitis group. These levels were statistically significant (p=0.03; p=0.02, respectively). Sensitivity for DPP4 was 50% versus 64% for CRP and 57% for INL. Specificity of DPP4 was 83% compared to 70% for CRP and 76% for INL.
Conclusions: Compared to CRP and INL, DPP4 levels showed lower sensitivity but higher diagnostic specificity in our population. In acute appendicitis, DPP4 levels could be an early indicator in addition to imaging and clinical assessment of patients.
Incidence and pattern of congenital heart disease in children: an observational cross-sectional study
Authors: Ullah Mohammad Ata , Mamun Sumaiya , Saha Heemel , Al-Miraj A. K.
Published: February 2025

Background: The objective of this study was to analyse the incidence, pattern, and clinical presentation of congenital heart disease in children and evaluate associated risk factors.
Methods: This observational cross-sectional study included 100 children aged 0-14 years diagnosed with CHD at department of cardiac surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh duration of study was 1 year starting from January to December 2022. Detailed clinical evaluation, echocardiography, and relevant investigations were performed for all cases. Associated anomalies and maternal risk factors were documented.
Results: Of 100 cases, 56% were males and 44% females (ratio 1.27:1). The majority (68%) were diagnosed in the first year of life. Acyanotic CHD predominated (72%) with ventricular septal defect being the most common lesion (30%), followed by atrial septal defect (15%) and patent ductus arteriosus (12%). Among cyanotic CHD (28%), tetralogy of Fallot was most frequent (15%). Common presenting features included breathing difficulty (45%), failure to thrive (38%), and recurrent respiratory infections (35%). Associated anomalies were present in 22% cases, with Down syndrome (8%) being the most common genetic association. Significant maternal risk factors included advanced age (15%) and diabetes mellitus (8%).
Conclusions: The study demonstrated patterns of CHD consistent with global literature while highlighting regional variations. Early detection was achieved in the majority of cases, though late presentation remains a concern. The findings emphasize the need for comprehensive screening programs and improved healthcare access, particularly in resource-limited settings. Understanding these patterns can guide resource allocation and healthcare planning for better management of pediatric cardiac care.
Antidiabetic effects of n-hexane extract of terminalia catappa nuts in Wistar rats induced with hyperlipidaemia and hyperglycaemia
Authors: Batubo Nimisoere P. , Reuben Edith , Opusunju Boma H. , Sunday Ogbu Ojeka , Datonye Victor Dapper
Published: February 2025

Background: Hyperlipidaemia and hyperglycaemia significantly impair pancreatic function and glucose metabolism, necessitating therapeutic interventions. This study investigated the effects of n-hexane extract of Terminalia catappa nut (TCN) extract on glucose homeostasis and pancreatic histology in hyperlipidaemic and hyperglycaemic Wistar rats.
Methods: Wistar rats were divided into six groups: negative control, positive control, standard drug control (atorvastatin and metformin), and TCN-treated groups (200, 400, and 800 mg/kg). Fasting blood glucose (FBG), insulin levels, and HOMA indices were measured, and pancreatic tissue was histologically examined. Data were analysed using one-way ANOVA followed by Tukey's post-hoc test for multiple comparisons, with significance set at p<0.05.
Results: TCN treatment produced dose-dependent improvements in glucose metabolism. The 800 mg/kg TCN group exhibited significant reductions in FBG (4.56±0.03 mmol/l) and insulin resistance (HOMA2-IR: 1.30±0.10) and near-normal insulin levels (11.85±1.20 μU/ml), comparable to the negative control. Beta-cell function (HOMA2%B) improved progressively with TCN, with the 800 mg/kg dose achieving values similar to the negative control (118±4.00). Histologically, the negative control group displayed intact islets of Langerhans and organized acinar cells. Conversely, the positive control group showed severe necrosis, inflammation, and disrupted islets. TCN treatment demonstrated dose-dependent histological recovery, with the 800 mg/kg group achieving near-complete restoration of pancreatic architecture.
Conclusions: TCN extract improves glucose homeostasis, enhances beta-cell function, and restores pancreatic integrity in hyperlipidaemic and hyperglycaemic conditions. These findings highlight the therapeutic potential of TCN as an adjunct for managing metabolic disorders.
A retrospective analysis: comparison of nephrotoxicity caused by concurrent weekly cisplatin in patients of head & neck cancer and cervical cancer
Authors: Ranjan Prabhat , Raveendran A. , Ravichandran A. , Manickavasagam M. , Siri Kavuru Naga , Mondal Victor , Chakravarthy Kavi , Lakshmi Ramya , Vuppumala Bhargav
Published: February 2025

Background: Cisplatin is the most common chemotherapeutic drug which is used concurrently with radiation therapy due to its radio sensitizing effect. Cisplatin is known to cause substantial amount of nephrotoxicity and adequate hydration is absolutely essential while administering cisplatin. Once weekly regimen is widely used both in the treatment of head & neck cancers as well as cervical cancer. The main aim of this study is to compare the incidence and severity of nephrotoxicity in patients of head and neck and cervical cancer treated with concurrent chemoradiation
Methods: From January 2023 to December 2023, data of 50 patients each of head and neck cancer and cervical cancer patients treated at our institute was evaluated. Cisplatin was used weekly at the dose of 40 mg/m2 with adequate hydration and necessary pre medications in all the patients. CBC, RFT and Serum Electrolytes were done prior to each cycle. RIFLE criteria were used to classify renal impairment
Results: 50 patients each of head and neck and cervical cancer were selected. Total 5 cycles of concurrent cisplatin were planned in both the arms according to the institutional protocol. During the course of treatment, Renal impairment was seen in 32 out of 50 patients (64%) in head and neck cancer arm whereas in ca cervix arm it was seen in only 14/50 patients (28%)
Conclusions: Renal impairment is more pronounced in head and neck cancer patients as compared to cervical cancer patients thus more aggressive hydration measures are required in patients of head and neck cancer.
Study of understanding, awareness and compliance to treatment in patients of hypertension at tertiary care center, SSG Hospital, Vadodara: a descriptive cross-sectional study
Authors: Bhudhrani Divyang , P. Patel Kush , P. Patel Yashvi , J. Patel Jinesh , S. Patel Rudra , V. Patel Zeel
Published: February 2025

Background: Hypertension represents a major health issue, significantly contributing to the prevalence of cardiovascular diseases worldwide. Effective hypertension management is largely dependent on patients’ understanding, awareness, and adherence to prescribed treatments. This study aimed to assess the levels of understanding, awareness, and compliance with treatment among hypertensive patients at SSG Hospital, a tertiary care center in Vadodara.
Methods: This descriptive cross-sectional study involved 300 hypertensive patients from the outpatient department of SSG Hospital, Vadodara. Data were gathered using a structured questionnaire that included demographic details, understanding about hypertension, awareness of its complications, and adherence to medications and lifestyle adjustments. Blood pressure measurements confirmed hypertension status. Statistical analyses were conducted using SPSS software to identify significant factors influencing treatment compliance.
Results: Among the 427 participants, 62% demonstrated sufficient understanding of hypertension, its risk factors, and complications. Awareness was high, with 75% of patients recognizing the importance of regular medication and lifestyle changes. However, only 54% of patients were fully compliant with their treatment regimens. Higher education levels, consistent follow-up visits, and family support were significantly associated with better compliance.
Conclusions: Although the majority of hypertensive patients at SSG Hospital, Vadodara, have substantial knowledge and awareness of their condition, treatment compliance remains suboptimal. Improving patient education, providing ongoing support, and addressing barriers to adherence are essential for better management of hypertension.
Attachment styles and depression among nursing officers of tertiary care centre in India
Authors: Mamta  , Parihar Aashish , Kumar Ashok
Published: February 2025

Background: The concept of attachment plays a relevant role in mental health. Attachment style refers to how a person perceives and experiences interpersonal relationships. There are various attachment styles or patterns through which an individual attaches or form relationships with others. Attachment has a persistent and long-term impact on depression. The main aim of the study is to assess the attachment styles and depression among nursing officers of tertiary care centre in India.
Methods: Descriptive research design was used. The study was conducted at all India institute of medical sciences (AIIMS), Jodhpur among 250 nursing officers selected by convenient sampling technique. Self-structured attachment style questionnaire was used to assess the attachment style and structured questionnaire centre for epidemiologic studies depression scale was used to assess the depression among nursing officers. Data analysis was done by using statistical package for social sciences-version 25 (SPSS-25). Frequency, percentage, mean, standard deviation, chi square test, Fisher exact test and Pearson correlation were used.
Results: Result revealed that out of 250, majority 213 (85.2%) nursing officers had secure attachment style. Majority 183 (73.2%) nursing officers were normal, showed no depression. Moderate negative correlation was there between secure attachment style and depression scores. Strong positive correlation was found between anxious attachment style and depression scores. There was moderate positive correlation between avoidant, fearful attachments and depression scores respectively.
Conclusions: The study indicates that majority of nursing officers were having secure attachment style and were normal, showed no depression. The study established a relationship between attachment style and depression.
Factors contributing to acute heart failure after a first acute coronary syndrome episode
Authors: Khan Shehla Ashraf , Kothari Aanshi S. , Shrivatsam Paidi , Modi Sagar M. , Narayan Jagadale Pratik
Published: February 2025

Background: Factors that speed up the development of acute heart failure (AHF) after acute coronary syndrome (ACS), are understudied in developing country like India. Therefore, this study was aimed to determine the risk factor of heart failure (HF) among the post-ACS patients.
Methods: This  descriptive  cross-sectional  study  was  performed  at Government General  Hospital  (GGH) Srikakulam, Andhra Pradesh, India. 108 patients who were admitted with HF cardiology unit of GGH after ACS from September 2023 to November 2024 were enrolled in the study. An established inclusion and exclusion criteria along with consecutive sampling technique were used for patients’ recruitment. A self-structured proforma was applied to gather data. Data analysis was done in the statistical package for the social sciences (SPSS) version 25.0.
Results: Clinical features, including glucose levels, dyslipidemia, COPD, and medication history, were analyzed in patients with and without ACS. HF was more common in those aged≥40 years (69.23%), male (62.82%), and with anterior wall myocardial infarction (38.46%). Key risk factors included reduced ejection fraction (67.90%), left anterior descending artery pathology (17.95%), absence of myocardial revascularization (46.15%), diabetes mellitus (52.56%), hypertension (78.20%), anemia (53.85%), hyperlipidemia (75.64%), and smoking history (51.28%). Additionally, glucose dysregulation, dyslipidemia, COPD, and medication history influenced HF progression.
Conclusions: Factors such as an age group with 40 years or above, male gender, anterior wall myocardial infarction, reduced ejection fraction, left anterior descending artery pathology, absence of myocardial revascularization procedure, diabetes mellitus, hypertension, anemia, hyperlipidemia, and history of smoking, all accelerate the development of HF among post-ACS patients.
Study of prescription pattern of antihypertensives in diabetes with hypertension patients in geriatric population at tertiary care centre: a prospective observational study
Authors: Pal Avinash D. , Baig Mirza S. , Rao Shailaja
Published: February 2025

Background: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are prevalent chronic conditions that significantly affect elderly health, especially in India, where the dual occurrence of these diseases exacerbates cardiovascular risks. This study examines the prescription patterns of antihypertensive medications in geriatric patients with both conditions at a tertiary care center in Maharashtra, India.
Methods: A prospective, cross-sectional study was conducted at government medical college, Aurangabad, from March 2023 to August 2024. Patients aged 60 and older with HTN and T2DM were included. Prescription data for antihypertensive medications were collected and analyzed.
Results: The study included 1023 prescriptions, with 57.09% male patients. The most commonly prescribed antihypertensives were telmisartan (38.05%) and amlodipine (31.96%). Monotherapy was prescribed to 22.48% of patients, while 61.97% received two-drug combinations, and 14.66% received three-drug combinations. Only 0.88% of patients were prescribed more than three drugs. The most common combination therapy was Telmisartan and Amlodipine (59.78%). The majority of prescriptions were generic (91.18%), and 85.23% were from the national essential drug list (EDL) (India 2022), indicating cost-effective and standardized treatment practices.
Conclusions: The study reveals a preference for ARBs and calcium channel blockers for managing HTN in elderly patients with T2DM. The widespread use of combination therapies and generic drugs reflects an efficient approach. Additionally, the study follows the WHO prescription parameters, with the average number of drugs per encounter being 1.93, and a high percentage of prescriptions aligning with EDLs.
Neutrophil-to-lymphocyte ratio as predictor of nausea and vomiting after elective laparoscopic cholecystectomy
Authors: Kumar Gupta Amit , Rajput Deepak
Published: February 2025

Background: The neutrophil-lymphocyte ratio (NLR) or platelet-lymphocyte ratio (PLR) has been proposed as a parameter for the diagnosis of inflammatory diseases in different studies; however, the literature does not discuss this relationship for elective laparoscopic cholecystectomy. The purpose of this study was to determine whether preoperative NLR or PLR is associated with postoperative nausea and vomiting (PONV), one of the most common postoperative complications and whether it may act as a biomarker for the illness.
Methods: The clinical data of 146 patients with symptomatic cholelithiasis who underwent elective laparoscopic cholecystectomy (ELC) at our institution were collected and analyzed.
Results: We divided patients into PONV and No-PONV groups. and logistic regression analysis was used to identify predictors for PONV. In logistic regression analysis, the preoperative neutrophil-to-lymphocyte ratio (NLR) [odds ratio (OR): 1.61, 95% confidence interval (CI), p=0.01] was identified as an independent risk factor for the presence of PONV. On ROC analysis, the success of NLR in discriminating PONV was found to be statistically significant [area under curve (AUC)=0.631, p=0.01].
Conclusions: PONV can be predicted in patients undergoing ELC with NLR. As a result, blood parameters should be examined to enhance these patients’ post-operative recovery period.
Prevalence of fecal carriage of vancomycin resistant Enterococci in a tertiary care centre in South India
Authors: Murugesan Vinitha , Gounassegarane Dhanalakshmi , Karanam Gnanaprakash , Jayarajan Jayalakshmi
Published: February 2025

Background: The number of VRE infections gradually increases worldwide and ICUs in hospitals which remains to be the major reservoir of antibiotic-resistant organisms. The current study was carried out to determine prevalence of fecal carriers of vancomycin resistant Enterococci in a tertiary care hospital, thereby preventing the spread of vancomycin resistant Enterococci to patients under high risk.
Methods: A total of 219 stool samples and rectal swabs were collected from health care workers and ICU patients and processed in vancomycin resistant Enterococci agar and subjected to certain phenotypic tests for its species identification. Antimicrobial susceptibility testing was done for all the vancomycin resistant enterococcal isolates.
Results: A total of 73 VRE were isolated of which 64 (36%) were from HCW and 9 (22%) were from ICU patients.   The prevalence of VRE was 33% and the most common VRE isolated was Enterococcus faecium. All the 73 VRE isolates were susceptible to linezolid and 52% were susceptible to quinpristine/dalfopristine.
Conclusions: Screening of stool samples aids in the prevention of spread of multi-drug resistant VRE isolate from HCW to high risk patients. It’s imperative to step up infection control strategies so as to curtail its spread.
A study on the paediatric cases admitted in the otorhinolaryngology department in a tertiary care centre
Authors: Yasmin Sabrina Islam , Sangma Rupanjita , Moran Nirupama
Published: February 2025

Background: In paediatric otorhinolaryngology, abnormalities of the nose, throat, and ears are studied about the development of the head and neck structures. Otorhinolaryngological problems are one of the most common causes of medical consultation among paediatrics. The purpose of this retrospective study is to identify the disease patterns among hospitalized paediatric patients at the Assam Medical College and Hospital (AMCH) in the department of otorhinolaryngology. Aims and objective were to determine the pattern of otorhinolaryngology diseases among paediatric patients.
Methods: This retrospective study is conducted in the otorhinolaryngology department of Assam Medical College and Hospital (AMCH), Dibrugarh, Assam, from January 2023 to December 2023. The study was done on pediatric patients aged 0-12 years, presenting and admitted to the department of otorhinolaryngology, Assam Medical College and Hospital.
Results: A total of 144 cases are studied, which includes 73 males and 71 females with a male-to-female ratio of 1.03: 1. The most common otorhinolaryngological problem noted in our study was foreign bodies (29.86%) and diseases were chronic otitis media (4.16%), cervical lymphadenopathy (4.16%) and epistaxis (4.16%). Maximum cases were admitted in November (12.5%) and minimum cases were admitted in October (4.17%).
Conclusions: In the paediatric age range, otolaryngology emergencies are not unusual. Although the risk of death is low, there is a chance of increasing complications. The most common otorhinolaryngological problem noted in our study was foreign bodies and diseases were chronic otitis media, cervical lymphadenopathy and epistaxis. Parent and caretaker education about the diseases and prevention shall help limit the mortality and complications.
Understanding the clinical spectrum and etiological factors of acute kidney injury in patients at a tertiary care hospital, SSG Hospital, Vadodara: an observational study
Authors: Bhudhrani Divyang , Patel Yashvi P. , Patel Jinesh J. , Patel Kush P. , Patel Rudra S.
Published: February 2025

Background: Acute kidney injury (AKI) represents a significant burden on healthcare systems globally due to its high morbidity and mortality rates. Early identification and management are crucial to mitigate adverse outcomes and enhance patient prognosis. This study aimed to investigate the clinical spectrum and etiological factors contributing to AKI among patients at SSG Hospital, Vadodara.
Methods: This observational study aimed to characterize the clinical presentation of AKI patients and explore the diverse etiologies contributing to AKI in a tertiary care setting. The study assessed demographic profiles, clinical symptoms, and prevalent etiological factors associated with AKI. Conducted from October 1st, 2023, to March 31st, 2024, it included 246 patients aged over 18 years admitted to the medicine ward and intensive care unit, excluding those with diabetic nephropathy or chronic kidney disease. Data collection involved detailed histories, clinical examinations, and application of KDIGO criteria for AKI diagnosis. Statistical analysis was performed using SPSS 11.5 software.
Results: Among the 246 patients, 162 were male and 84 females, with a mean age of 50.6±18.00 years. Common symptoms included decreased urine output (60%), swelling (56%), and vomiting (34%). Principal etiologies were acute gastroenteritis (20%), snake bites (18.8%), infective causes (15.8%), and poisoning/drug-induced (15.2%). Significant associations were found between clinical features and etiological factors.
Conclusions: This study offers insights into the clinical spectrum and diverse etiological factors contributing to AKI at SSG Hospital, Vadodara. Findings emphasize the need for early recognition and tailored management strategies based on prevalent regional etiologies. Further research is needed to validate these results and refine therapeutic approaches.
Navigating advanced polycystic kidney disease: a case study of bilateral nephrectomy and life-saving transplant
Authors: Suooda Fathimath , Maleesha Fathimath , Ali Fathmath Zuha , Ivanovna Yulia Karpovich
Published: February 2025

This case report discusses a 60-year-old female with polycystic kidney disease (PKD) who developed end-stage renal disease (ESRD). Diagnosed with polycystic kidney and liver disease in 2004, her condition worsened over the years, ultimately requiring hemodialysis and, later, kidney transplantation. Pre-transplant preparations included bilateral nephrectomy due to extensive cystic involvement of both kidneys. Post-transplant follow-up showed marked improvement in kidney function, with careful management using immunosuppressive, antifungal, and antihypertensive medications to prevent rejection and infection. This case underscores the critical role of multidisciplinary care in PKD patients undergoing transplantation for ESRD.
A supraorbital nerve Schwannoma: a case report
Authors: Juan Orson R. , Baas Manuel A. , Juan Tomiko I. , Lezama Frida I. , Lozano Jose L.
Published: February 2025

Schwannomas are encapsulated tumors that originate in the peripheral this frequently affect sensory nerves, benign and with low incidence, characterized by a tumor under the skin, usually encapsulated, composed of well-differentiated neoplastic Schwann cells. They are the most common benign tumors of peripheral nerves of the head and neck region and in the extensor aspects of the limbs, but also in the spinal and cranial nerves, especially the vestibular nerve. We present the case of a female patient with schwannoma of the supraorbital nerve with neurological involvement associated with a progressively growing mass in the frontal region of the forehead. We show the clinical diagnosis process and the surgical treatment instituted to perform complete resection and functional preservation, with a definitive anatomopathological diagnosis of supraorbital schwannoma. Due to the infrequency of this pathology, we also perform a review of the literature on the subject.