bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Natural Compounds for Cardiovascular Research: Myeloperoxidase Inhibition and Toxicity Prediction Studies
Authors: Ferrari Ivan Vito
Published: February 2024

This study focused on the investigation of myeloperoxidase through a Molecular Docking approach with various natural compounds to identify potential substances for cardiovascular research. Recent research has linked elevated myeloperoxidase levels to the severity of coronary artery disease. The results of the docking analysis revealed Polydatin, Daidzin, Astringin, Ginkgetin, and Amentoflavone as promising compounds with excellent binding capacity. To complement this, toxicity prediction studies were conducted using pkCSM. Overall, all four investigated molecules (Amentoflavone, Daidzin, Ginkgetin, and Astringin) were found to be non-toxic, exhibiting high maximum tolerated doses (human) and favorable values for Oral Rat Acute Toxicity and Oral Rat Chronic Toxicity. Moreover, they showed non-AMES toxicity and non-hepatotoxicity. Astringin, in particular, stood out with the highest positive effects, including a high maximum tolerated dose (human) and favorable values for Oral Rat Chronic Toxicity, along with dual inhibition of hERG II and hERG I. These findings suggest the potential utility of these compounds in cardiovascular research with minimized unwanted effects.
Increasing Efficiency in Tertiary Buildings through PoE LVDC Nanogrid in the island of La Réunion
Authors: Graillet Olivia , Genon-Catalot Denis , Lucas de Peslouan Pierre-Olivier , Bernard Flavien , Alicalapa Frédéric , Lemaitre Laurent , Chabriat Jean-Pierre
Published: February 2024

In the context of the French tertiary decree, it is crucial to reduce the energy consumption of buildings by first addressing the design of the electrical architecture. Implementing Direct Current (DC) nanogrids in buildings could offers a promising advantage for energy efficiency, significantly impacting overall energy consumption and sustainability goals. For an insulated area with a subtropical climate, such as La Réunion island, DC nanogrids could also facilitate the insertion of local renewable energy sources, especially solar energy. This article presents the deployment and efficiency evaluation of an end-to-end Low Voltage Direct Current (LVDC) nanogrid, from conception to real-world installation within a company. The nanogrid consists of a photovoltaic power plant, a Lithium-Iron-Phosphate (LFP) battery, and DC end-use equipment such as LED lighting and DC fans for two individual offices. An innovation is provided for the power supply and energy management of terminal equipment using the Power Over Ethernet (PoE) standard IEEE 802.3bt. The efficiency of the nanogrid is measured to be 40% higher than the efficiency of an installation powered by PV and distributed at 230 VAC. These results are obtained under certain deployment conditions, which are discussed in this article, in order to enhance the energy efficiency of buildings by using 48VDC. The nanogrid hardware and software infrastructure, the methodology employed for efficiency quantification and the measurement results are described in the paper.
Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics
Authors: Fernández-Borbolla Andrés , García-Hevia Lorena , Fanarraga Mónica L.
Published: February 2024

Nanoencapsulation has emerged as a recent improvement in the delivery of drugs, offering and improving stability and bioavailability, and allowing for the controlled and targeted delivery of substances to specific cells or tissues. However, traditional nanoparticle delivery faces challenges such as short circulation time and immune recognition. To address these issues, cell membrane-coated nanoparticles have been proposed as a promising alternative. The production of cell membrane-coated nanoparticles involves three key stages: cell lysis and membrane fragmentation, membrane isolation, and nanoparticle coating. Typically, cell membranes are fragmented using hypotonic lysis in combination with homogenization or sonication. Subsequent membrane fragments are isolated through multiple centrifugation steps. The coating of nanoparticles can be achieved through extrusion, sonication, or a combination of both methods. This analysis shows the absence of a universally applicable method for nanoparticle coating, as the three stages exhibit notable differences in their procedures. Here we review ongoing developments and approaches to cell membrane-coated nanoparticles that position this technology as a promising alternative for effective targeted drug delivery and many other therapeutic applications.
Energy Modeling for Electric Vehicles Based on Real Driving Cycles: An Artificial Intelligence Approach for Microscale Analysis
Authors: Mądziel Maksymilian
Published: February 2024

The paper outlines a methodology for developing a model to estimate energy consumption in electric vehicles (EVs). The most robust validation indicators were exhibited by an artificial intelligence method, specifically neural networks. Within this framework, two predictive models for EV energy consumption were developed for winter and summer conditions, based on actual driving cycles. Such models hold particular significance for microscale road analyses. The resultant model for test data in summer conditions demonstrates validation indicators with an R2 of 86% and an MSE of 1.4, while for winter conditions, the values are 89% and 2.8, respectively, confirming its high precision. The paper also presents exemplary applications of the developed models, utilizing both real and simulated microscale data. The results obtained and the presented methodology can be especially advantageous for decision-makers in city road management and infrastructure planners, aiding both cognitive understanding and better planning of charging infrastructure networks.
Psychological Factors, Digital Health Technologies and Best Asthma Management: Three Fundamental Factors in Modern Care
Authors: Caponnetto Pasquale , Prezzavento Graziella Chiara , Casu Mirko , Quattropani Maria Catena
Published: February 2024

New digital interventions have shown potential in managing asthma and improving patients' quality of life compared with conventional interventions. Our objective was to conduct an exhaustive survey of the application of digital health technologies in evaluating, treating, and self-managing psychological and psychopathological elements linked to asthma. We analyzed a compendium of research papers and systematic reviews pertaining to asthma, encompassing themes such as outdoor air pollution, early life wheezing disorders, atopic dermatitis, digital strategies for asthma self-management, psychiatric conditions and asthma, familial impacts on pediatric asthma, and the utilization of mobile health apps for managing asthma. We scrutinized eight chosen studies to evaluate the capacity of digital health technologies to enhance the man-agement and treatment outcomes of psychological factors related to asthma. The studies under review indicate that eHealth interventions, mixed reality instruments, mHealth technolo-gy-augmented nurse-led interventions, and smartphone apps incorporating Bluetooth-enabled sensors for asthma inhalers can markedly enhance self-management of symptoms, quality of life, and mental health outcomes, particularly in children and adolescents with asthma. Nonetheless, additional research is required to ascertain their efficacy and practicability across diverse populations and environments. Customized interventions that cater to the unique needs and preferences of asthma patients and associated psychological elements are vital to ensure the persistent and equitable adoption of these technologies. We underscore the significance of addressing psychological elements in the management and treatment of asthma and advocate for ongoing research and development in this domain.
Performance of Self-Sensing Cementitious Composite under Various Loading Conditions
Authors: Roshan Mohammad Jawed , Abedi Mohammadmahdi , Gomes Correia António , Fangueiro Raul
Published: February 2024

Numerous elements, such as the composition and characteristics of carbon nanomaterials, the composition and characteristics of the matrix material, moisture levels, temperature, and loading circumstances, influence the piezoresistive behaviour of self-sensing cementitious composites. While some past research has explored the impact of some of these factors on the performance of self-sensing cementitious composites, additional investigations need to be conducted to delve into how loading conditions affect the sensitivity of self-sensing cement-stabilized composites. Therefore, this study explores the influences of various loading conditions (i.e., location of loading regarding the location of recording electrodes, and loading level) on the electromechanical performance of self-sensing cement-stabilized sand. To this end, firstly, the evaluation of the percolation threshold based on 10% cement-stabilized sand specimens containing various multiwall carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs) was performed. Then, 10% cement-stabilized sand containing 4% MWCNTs/GNPs was tested under various cyclic compressive stresses. The results suggested that the distance between the loading area and the electrode location used for recording the electrical resistance significantly impacts the sensitivity of cement-stabilized sand. Optimal sensitivity was achieved when the electrodes were positioned directly beneath the loading area. Moreover, the study yielded that the stress sensitivity of self-sensing cement-stabilized sand increases proportionally with the stress level. Examination through scanning electron microscopy (SEM) demonstrated that the loading condition influences the bridging characteristics of carbon nanomaterials in cement-stabilized sand, leading to diverse electromechanical behaviors based on the loading condition. This study underscores the importance of considering specific parameters when designing the application of self-sensing cement-stabilized sand for practical field use.
Functional, Structural and Proteomic Effects of Ageing in Resistance Arteries
Authors: Jensen Lars Jørn
Published: February 2024

The normal ageing process significantly affects resistance arteries, leading to various biological and physiological consequences. Systolic hypertension is a common occurrence in ageing individuals, accompanied by increased large artery stiffening, heightened pulsatility, small artery remodeling, and damage to critical microvascular structures. Starting from young adulthood, there is a progressive elevation in mean arterial pressure, supported by clinical and epidemiological evidence as well as findings from animal models. The myogenic response, a protective mechanism for the microcirculation, may face disruptions during ageing. Dysregulation of calcium entry channels (T-type, L-type, TRP channels), dysfunction in intracellular calcium storage and extrusion mechanisms, altered expression of potassium channels, and a change in smooth muscle calcium sensitization may contribute to age-related dysregulation of myogenic tone. Flow-mediated vasodilatation, a hallmark of endothelial function, is compromised in ageing. This result of endothelial dysfunction is related to oxidative stress, lower nitric oxide bioavailability and a low-grade inflammatory response, further exacerbating vascular dysfunction. Resistance artery remodeling in ageing emerges as a hypertrophic response of the vessel wall, often seen in conjunction with outward remodeling (in normotension), but can also present as inward hypertrophic remodeling (in hypertension). The remodeling process involves oxidative stress, inflammation, reorganization of extracellular matrix fiber proteins and actin cytoskeletal components. Reactive oxygen species (ROS) signaling and chronic low-grade inflammation, often referred to as "inflammaging”, play substantial roles in age-related vascular dysfunction. Due to its role in regulation of vascular tone as well as structural proteins, the RhoA/Rho-kinase pathway becomes a new target in age-related vascular dysfunction and associated diseases. Understanding the intricate interplay of these factors is crucial for developing targeted interventions to mitigate the consequences of ageing on resistance arteries and enhance overall vascular health.
Design and Fluid-Structure Coupling Analysis of Far-Field Flat Mirror for AliCPT-1 Telescope Calibration
Authors: Cai Jianrong , Zhang Aimei , Li Xufang , Liu Congzhang , Li Yongping , Xin Zhongxue , Li Zhengwei , Lu Xuefeng
Published: February 2024

: AliCPT-1 is the first Cosmic Microwave Background (CMB) experiment in China, dedicated to achieve accurate measurements of B-mode polarization. Situated in Ali of Tibet, China, this telescope is currently undergoing deployment and will operate in two frequency bands centered at 90 and 150 GHz. The Far-Field Flat Mirror（FFF）is a calibration device of AliCPT-1 telescope for far-field beam mapping. The design of FFF is optimized for easy assembly and adjustment. Meteorological station data reveals that the maximum wind speed near FFF is 17.5 m/s, while the maximum wind speed on the windward side is 8 m/s. The wind pressure on FFF was analysed using a maximum wind speed of 17.5m/s as the input condition, based on the fluid-structure coupling method in ANSYS. The results demonstrate that it is safe and reliable when withstanding combined gravity and wind pressure loads. The torque on the mount is within the motor rated torque. The flatness of the FFF reflective surface can be adjusted to an RMS value of 0.05 mm when taken into account the effect of gravity and assembly accuracy. The deformation caused by the maximum wind loads is approximately 0.0587 mm under the protection of wind-proof wall. The combined deformation is 0.077 mm in RMS value combining the two influences, which is less than 1/20 of wavelength. The FFF mirror assembly is stable and precisely for telescope calibration.
Fungal Methane Production Controlled by Oxygen Levels and Temperature
Authors: Schroll Moritz , Lenhart Katharina , Bender Thomas , Hötten Piet , Rudolph Alexander , Sörensen Sven , Keppler Frank
Published: February 2024

Saprotrophic fungi are key in global carbon cycling, capable of decomposing lignocellulose in wood. This study, for the first time, explores the influence of oxygen (O2) and temperature on methane (CH4) production by two fungi, Laetiporus sulphureus and Pleurotus sapidus. We examined CH4 formation under varying O2 levels (0 to 98%) and temperatures (17, 27, and 40 °C) when the fungi grew on pine wood, beech wood, and grass under sterile conditions. Our findings reveal a strong dependency of fungal CH4 production on O2 mixing ratios. Methane formation was highest when O2 levels exceeded 5%, whilst no CH4 formation was observed after complete O2 consumption by the fungi. Reintroducing O2 immediately resumed fungal CH4 production. When CH4 formation was normalized to O2 consumption (CH4_norm) a different pattern between species was observed. L. sulphureus showed higher CH4_norm rates with higher O2 levels, whereas P. sapidus showed elevated rates between 0-5% O2. Temperature also significantly influenced CH4 and CH4_norm rates, with the highest production at 27 °C, and comparatively lower rates at 17 and 40 °C. These results demonstrate that O2 levels and temperature are critical in controlling fungal CH4 emissions, a consideration necessary for future CH4 source predictions.
Evolutionary Reinforcement Learning of Neural Network Controller for Acrobot Task — Part3: Differential Evolution
Authors: Okada Hidehiko
Published: February 2024

Evolutionary algorithms find applicability in reinforcement learning of neural networks due to their independence from gradient-based methods. To achieve successful training of neural networks using evolutionary algorithms, careful considerations must be made to select appropriate algorithms due to the availability of various algorithmic variations. In Part1 and Part2, the author previously reported experimental evaluations on Genetic Algorithm and Evolution Strategy for reinforcement learning of neural networks, utilizing the Acrobot control task. This article constitutes Part3 of the series of comparative research. In this study, Differential Evolution is adopted as the third instance of major evolutionary algorithms. The experimental results show a statistically significant superiority of DE over both GA and ES (p < .01). In addition, DE exhibits its robustness to variations in hyperparameter configurations (the number of offsprings and generations). In the previous experiments, both ES and GA showed significant performance differences depending on the configurations, whereas in the experiment reported in this article, such differences are not detected for DE.
Serpihan Hati yang Tangguh di Kala Pandemi
Authors: Setiawan Hamzah
Published: February 2024

Rasa syukur selalu tercurah kepada Allah SWT yang senantiasa melimpahkan rahmat, hidayah serta kesehatan, sehingga kami dapat melaksanakan program Kuliah Kerja Nyata Tangguh (KKN-Tangguh) Universitas Muhammadiyah Sidoarjo tahun 2020. Kuliah Kerja Nyata (KKN) adalah program yang ditempuh mahasiswa Universitas Muhammadiyah Sidoarjo merupakan perwujudan dari salah satu Catur Dharma Perguruan Tinggi, yaitu bermaksud memberikan pengalaman secara langsung baik fisik maupun mental kepada calon sarjana dengan terjun bersama masyarakat dengan menerapkan ilmu jurusan masing-masing. Didalam KKN-Tangguh 2020 Universitas Muhammadiyah Sidoarjo, lokasi kegiatan tersebar di berbagai wilayah yakni Cangkring Sidokare, Sumberingin Gempol, Canggu Mojokerto, Sidowayah Sidoarjo, Dsn Tebuseren Jabon, Perum Persona Sari, Sawotratap Gedangan, Cangkring Krembung, Ploso Wonoayu, Gebang, Anggaswangi, Dsn Carat Gempol, Ds Prasung Buduran, Sugihwaras candi, Urang Agung Sidoarjo.
Antara Pengabdian dan Hidup di Masa Pandemi
Authors: Hanun Nur Ravita
Published: February 2024

Rasa syukur selalu tercurah kepada Allah SWT yang senantiasa melimpahkan rahmat, hidayah serta kesehatan, sehingga kami dapat melaksanakan program Kuliah Kerja Nyata Tangguh (KKN-Tangguh) Universitas Muhammadiyah Sidoarjo tahun 2020. Kuliah Kerja Nyata (KKN) adalah program yang ditempuh mahasiswa Universitas Muhammadiyah Sidoarjo merupakan perwujudan dari salah satu Catur Dharma Perguruan Tinggi, yaitu bermaksud memberikan pengalaman secara langsung baik fisik maupun mental kepada calon sarjana dengan terjun bersama masyarakat dengan menerapkan ilmu jurusan masing-masing.
Effects of Stress on Transport Properties in Fractured Porous Rocks
Authors: Ba Jing , Min Jinyi , Zhang Lin , Carcione José M.
Published: February 2024

The nonlinear characteristics of the rock transport properties (permeability and electrical conductivity in this study) as a function of stress are closely related to the geometry of the pore space, which consists of stiff pores, microcracks, or microfractures. We consider two behaviors of the pore space, one linear and the other exponential, related to the stiff pores and microfractures, respectively, where the relation between stress and strain can be described by the Two-Part Hooke’s Model. With this model, the relations between porosity, transport properties, and effective stress (confining minus pore pressure) can be obtained and validated with the experimental data of four tight sandstones collected from the Shaximiao Formation of Sichuan Basin, southwest China. The agreement is good. At low effective stresses, the closure of cracks is the main mechanism affecting the transport properties, whose behavior is similar in terms of their parameters. Subsequently, experimental data of nine tight sandstones from the Yanchang Formation, collected from the Ordos Basin, west China, are employed to confirm the previous results, indicating that the fluid and electrical current follow the same path in the pore space.
La implementación de plan de marketing para la marca de ropa Yemicat
Authors:   , Arriaga Mendoza Andres Alexander , Sotelo Escobar Aldrin Jhonny
Published: February 2024

El propósito principal de esta tesis es llevar a cabo un análisis exhaustivo del contexto en el que opera la empresa YEMICAT, la cual se dedica al sector textil en el mercado peruano. Este análisis del entorno tiene como objetivo brindar una visión general de los factores demográficos, económicos, políticos, legales, socioculturales y otros que afectan tanto a la industria textil en general como a la empresa en particular. En relación al análisis demográfico, se examinará el desarrollo de la población peruana y su distribución en las diferentes regiones del país, así como las tendencias de natalidad y mortalidad. También se considerarán los datos sobre migración y su impacto en la población. En el análisis económico, se evaluará el crecimiento del Producto Bruto Interno (PBI) en el sector manufacturero, específicamente en la industria textil. Asimismo, se analizará el aporte de las micro, pequeñas y medianas empresas (MIPYMES) al PIB, así como las medidas implementadas por el gobierno para respaldar a estas empresas durante la pandemia de COVID-19. En el ámbito político y legal, se examinarán las normativas laborales aplicables a las micro y pequeñas empresas (MYPEs) y se evaluará el panorama político durante el período de estudio. Se prestará especial atención a la estabilidad política y su impacto en el entorno empresarial. El análisis sociocultural se enfocará en la demanda de productos básicos y cómo esta demanda afecta al mercado textil. Se explorarán las tendencias de consumo, las preferencias de los clientes y las oportunidades laborales generadas por esta demanda. Por último, se considerarán otros factores como el avance tecnológico y la expansión a nivel global, los cuales están cambiando la forma en que las empresas tradicionales operan en el mercado. Se resaltará la importancia de la actividad en línea…
Prevalencia de dientes impactados y dientes supernumerarios por valoración radiográfica en centros de diagnóstico por imágenes de tres países latinoamericanos
Authors:   , Tetay Salgado Sindy
Published: February 2024

Introducción: La hiperodoncia es un trastorno dental donde se supera la formula dental habitual, existen diferentes diferenciarlos lo cual depende de su disposicion anatómica, entre otros aspectos; son diversas las teorias que lo ocasionan. Objetivo: Determinar la prevalencia de dientes impactados y supernumerarios en una muestra de radiografías panorámicas de tres países de Latinoamericanos. Materiales y Métodos: Estudio descriptivo retrospectivo con enfoque cuantitativo, se realizó observación y análisis radiográfico de 2000 radiografías panorámicas, suministradas por diferentes centros radiológicos de Perú, Colombia y Bolivia. Todas las imágenes fueron evaluadas en cuarto oscuro en formato digital; para determinar presencia de dientes supernumerarios e impactados, se utilizó el paquete de SPSS versión 23, para el análisis estadístico, se relacionó la edad, sexo y nacionalidad con la presencia de dientes impactados o supernumerarios, usando la prueba de chi cuadrado. El nivel de significancia aceptado de P < 0.05. Resultados: La prevalencia de dientes impactados fue de 1.7%, y la de supernumerarios fue de 3.15% (76 casos), el supernumerario con mayor frecuencia fue el Mesiodens con el 1.7%(34), siendo Perú el país que presentó mayor prevalencia de Mesiodens (chi cuadrado p=0.019). Conclusión: La prevalencia encontrada para dientes impactados es baja, siendo el canino superior izquierdo el diente impactado con mayor frecuencia. Igual comportamiento se presentó a dientes supernumerarios, siendo el mesiodens el supernumerario con mayor prevalencia.
Fenotipos de obesidad metabólica y su asociación con el Síndrome de fragilidad en adultos mayores
Authors:   , Ramirez Alarcon Lilian Beatriz , Rojas Silva Beatriz Ivette
Published: February 2024

Introducción: La fragilidad está definida como un síndrome médico con diversas causas y factores los cuales van a contribuir al desarrollo, que está caracterizado por una disminución de la resistencia, de la fuerza y reducción de las funciones fisiológicas, las cuales incrementan la vulnerabilidad del individuo al momento de desarrollarse la dependencia funcional y/o muerte. Objetivo: Determinar la asociación entre los fenotipos de obesidad metabólica y fragilidad en adultos mayores. Materiales y métodos: El estudio se definió como un análisis secundario con base de datos, transversal analítico retrospectivo de tipo observacional que utilizó los datos del estudio “Prevalence and factor associated with frailty among Peruvian older adults”. Se hizo un análisis Bivariado teniendo en cuenta la variable dependiente que es fragilidad, y se utilizó la técnica de Chi cuadrado, y finalmente se hizo regresiones de Poisson para cuantificar las asociaciones. Resultados: con respecto a la obesidad metabólica se encontró que un 45.52% de los participantes se categorizan como no obesos metabólicamente saludables y un 34.76% de ellos fueron no obesos no metabólicamente saludables. También se encontró que la frecuencia de fragilidad fue de 24.48% De igual manera, entre los pacientes con fragilidad un 73.52% fue catalogado como no obesos no metabólicamente saludables y un 13.52% como obesos no metabólicamente saludables. Asimismo, se encontró que los no obesos metabólicamente saludables y los obesos metabólicamente saludables tenían un mayor riesgo de fragilidad en comparación a los no obesos no metabólicamente saludables. En un modelo ajustado por las otras covariables encontramos que ser no obeso metabólicamente saludable incrementa la probabilidad de ser frágil en 2.99 veces y ser obeso metabólicamente saludable incrementa el riesgo de fragilidad en 3.06 veces, mas no se halló asociación entre ser obeso no metabólicamente saludable y fragilidad. Conclusiones: Se encontró que en obesos o no obesos…
Producción científica peruana sobre VIH/SIDA del 1986 al 2022: un análisis bibliométrico
Authors:   , Saravia Alvan Elena , Gomez Cornelio Lousiana Renata
Published: February 2024

Objetivos: Describir las características bibliométricas sobre los documentos publicados sobre VIH/SIDA de autores peruanos en Scopus, SciELO, Web of Science entre 1986 y 2022. Materiales y métodos: Estudio bibliométrico. Se recopilaron los documentos publicados entre 1986 y 2022 en Scopus, Web of Science y SciELO. Las redes de colaboración y las redes bibliométricas de palabras clave fueron creados en VosViewer 1.6.19. Mediante el paquete bibliometrix en R 4.2.2 se realizó el análisis de coautoría internacional. Resultados: Se analizaron 747, 669 y 126 registros en Scopus, Web of Science y SciELO respectivamente. El país con el que Perú presenta más coautoría fue Estados Unidos en las tres bases de datos. Además, la Universidad Peruana Cayetano Heredia lidera la producción nacional a nivel de instituciones. Conclusiones: La producción peruana sobre VIH/SIDA muestra una tendencia ascendente y con alto porcentaje de colaboración internacional en Scopus y Web of Science, principalmente de Estados Unidos.
Establecimiento de criterios de evaluación uniformes de uso obligatorio para evaluar la idoneidad de trabajadores en período de prueba y evitar el despido arbitrario
Authors:   , De Bustamante De la Puente Rafael Ignacio
Published: February 2024

La presente tesis presenta como objeto establecer criterios de evaluación uniformes para los trabajadores del sector privado durante el período de prueba, que confirmen que la extinción del vínculo laboral se debe a la falta de idoneidad del trabajador para el desarrollo satisfactorio de las labores y responsabilidades que conforman el puesto de trabajo. Para este fin se desarrollará la investigación con un enfoque cualitativo, con un diseño de tipo documental y será de nivel correlacional – aplicada. Las principales conclusiones obtenidas del estudio son que esta institución nace originalmente para posibilitar que empleador y empleado constaten la viabilidad de una relación dependiente a largo plazo, eximiendo al empleador de la obligación de indemnizar. Asimismo, se establece que la implementación de criterios estandarizados elimina la posibilidad de una actuación arbitraria del empleador al terminar el vínculo.
Resultados de la trabeculectomía con derivación supracoroidea en comparación con la trabeculectomía tradicional en pacientes de 40 a 70 años de una clínica oftalmológica de Lima, Perú
Authors:   , Perez Simons Rodolfo Antonio , Prado Rosas Stephano Rolando
Published: February 2024

Objetivos: El estudio tiene como objetivo comparar los resultados de dos tipos de cirugía, la trabeculectomía con derivación supracoroidea y la trabeculectomía tradicional, en pacientes de 40 a 70 años con glaucoma de ángulo abierto. Se evaluarán aspectos como la presión ocular, la agudeza visual, los medicamentos después de la cirugía y las complicaciones, con el propósito de determinar qué procedimiento es más efectivo y proporcionar información sobre esta nueva técnica quirúrgica para el tratamiento del glaucoma. Materiales y Métodos: Se realizará un estudio retrospectivo en un grupo de pacientes que se sometieron a una de estas dos cirugías. Se utilizarán historias clínicas proporcionadas por un instituto especializado que realiza estas cirugías. Resultados: El estudio involucró a 80 pacientes divididos en dos grupos: 40 para la trabeculectomía convencional y 40 para la trabeculectomía con derivación supracoroidea. La edad promedio fue de 66 años. Se agruparon según el tiempo de diagnóstico de glaucoma. No hubo diferencias significativas en la presión ocular ni en la agudeza visual entre los grupos en diferentes momentos de seguimiento. Sin embargo, el grupo de derivación supracoroidea tuvo un 15% menos de probabilidad de usar medicamentos postquirúrgicos en comparación con el grupo de referencia. La cirugía de derivación supracoroidea también se asoció con un mayor tiempo sin progresión del glaucoma. Conclusión: La trabeculectomía con derivación supracoroidea demostró ser más beneficiosa en términos de tiempo sin progresión del glaucoma y uso de medicamentos después de la cirugía en comparación con la trabeculectomía tradicional.
Riesgo cardiovascular y su relación con el trabajo por turnos en el personal de una Empresa de transporte interprovincial de pasajeros público - 2019
Authors:   , Cruz Lopez Laura Mirella
Published: February 2024

Objetivo: Determinar la relación entre el riesgo cardiovascular y el trabajo por turnos en el personal de una empresa interprovincial de transporte de pasajeros público, 2019. Materiales y Métodos: Estudio observacional, retrospectivo, transversal y de nivel correlacional. La población en estudio estuvo conformada por el total de trabajadores de una empresa de transporte interprovincial de pasajeros público. La muestra incluyó a 141 trabajadores seleccionados por muestreo aleatorio simple. Se utilizó la base de datos de las historias médicas de estos trabajadores. El riesgo cardiovascular se estimó utilizando las tablas de predicción de riesgo cardiovascular de la OMS/ISH. Se categorizó el turno de trabajo (trabajo fijo vs trabajo rotativo o trabajo por turnos). Se realizó un análisis bivariado en el software estadístico SPSS utilizando la prueba estadística Chi2 y F Exacta de Fisher, según corresponda. Resultados: La muestra incluyó en su mayor parte a trabajadores del sexo masculino (97.9%, n=138). El turno de trabajo predominante fue el trabajo rotativo (79.4%, n=112). La mayoría de los trabajadores presentó un riesgo cardiovascular bajo (94.3%, n=133). Los que mostraron un riesgo cardiovascular moderado desarrollaban un trabajo por turnos. El grupo de trabajo rotativo incluyó a la mayoría con diabetes y a la totalidad de fumadores actuales. Sin embargo, presentaron cifras menores de trabajadores con hipertensión arterial y colesterol alto. La relación entre el riesgo cardiovascular y trabajo por turnos no resultó significativa. Conclusiones: En esta empresa, el turno de trabajo predominante en los trabajadores de transporte fue el trabajo rotativo. La mayoría de trabajadores de la empresa de transporte interprovincial que trabajan por turnos presentaron un riesgo cardiovascular bajo. La asociación entre el trabajo por turnos y el riesgo cardiovascular no resultó significativa.
Síndrome de burnout y su influencia en la satisfacción laboral del personal sanitario de un hospital público de Cajamarca - Perú
Authors:   , Bazan Durand Jazmine Stephanie , Rojas Valqui Annellys Rossalym
Published: February 2024

Objetivo. Determinar la influencia del Síndrome de Burnout (SB) en la satisfacción laboral (SL) del personal sanitario de un hospital público en Cajamarca, Perú. Métodos. Se realizó un diseño transversal analítico. La población fueron trabajadores asistenciales sin restricción de edad y sexo. La recolección se hizo en el abril del 2023. La satisfacción laboral se midió mediante el cuestionario “Escala de Satisfacción Laboral” y el síndrome de Burnout mediante el “MBI-Human Services Survey (MBI-HSS)”. Se halló la asociación mediante el cálculo de la razón de prevalencia por medio de un análisis de regresión multivariado. Resultados. Se incluyeron a 132 sujetos, donde el 53% tenía menos 40 años y 7 de cada 10 eran mujeres. El 64 % era personal de enfermería entre técnicos y profesionales y de 3 de cada 4 tenían menos 5 años de trabajo. Del total de la muestra, el 49% presentó SB y el 31.8% presentó mala SL. La prevalencia de mala satisfacción laboral fue del 21.9% en aquellos con SB y del 41.2% entre aquellos que no presentaron SB (p=0.017). En el análisis multivariado la presencia de SB se asocia a una menor prevalencia de mala satisfacción laboral, disminuyendo en un 52% ajustado a edad y sexo (RP 0.48; IC95%; 0.29. a 0.81; p=0.006). Conclusión. En esta población, la presencia del Síndrome de Burnout se asocia a una menor prevalencia de la mala satisfacción laboral. Ser una población joven y de poco tiempo laboral podría interferir en la asociación. Se requieren estudios prospectivos para confirmar esta relación en poblaciones similares.
Reservoir Modeling Predicts Effect of Cold-Water Injection on Geothermal PTA
Authors: Carpenter Chris
Published: February 2024

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 212615, “Reservoir Modeling To Predict the Effect of Cold-Water Injection in Geothermal Pressure Transient Analysis,” by Purnayan Mitra, SPE, University of Petroleum and Energy Studies, and Nihal Mounir Darraj, SPE, Imperial College London. The paper has not been peer reviewed.

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Geothermal reservoirs are one of the cleanest renewable sources of energy poised to address the global energy challenge. A major issue in the exploitation of geothermal reservoirs, however, is to find best-fit analytical methods for pressure transient analysis (PTA). This is because the assumptions made to predict PTA in hydrocarbon reservoirs are not satisfied by geothermal reservoirs. In the complete paper, the effect of cold-water injection on PTA of geothermal reservoirs is studied by varying the temperature of the injected cold water from room temperature to reservoir temperature.

Introduction

A major method of extracting heat energy from the Earth is the injection of water. Cold water is injected deep into geothermal reservoirs at a depth of 2–4.5 km. In this environment, cold water is essentially heated by the hot granite rock. Hydraulic fracturing is used to produce a large crack within the geothermal reservoir. Two boreholes intercept the crack. These boreholes are used for passing the cold fluid stream and the hot stream, respectively. In many scenarios, the gradient within the geothermal reservoir is so strong that a dry stream is produced. The greater the temperature difference between the injected fluid and the interior of the Earth, the greater the heat transfer. Therefore, it is always desirable to inject cold water inside geothermal reservoirs to maximize heat transfer and extract more heat. The steam coming out from the reservoir after heat transfer is used to run turbines to generate electricity. The steam also is used for a variety of other purposes. However, instances exist in which the temperature gradient is not as high, and it is difficult to produce a sufficiently heated dry stream. In such cases, an organic Rankine cycle is used for heating the steam on the surface. In such a case, the hot water or steam mixture is passed through a heat exchanger for heating the fluid to a desired temperature.

When cold water is injected into the reservoir, a need exists to analyze the pressure transience throughout the reservoir. Different formations affect PTA in different ways. PTA across the geothermal reservoir currently is performed using the empirical correlations available for hydrocarbon reservoirs. Although the method is not 100% effective because of differences in reservoir parameters, PTA provides an idea about reservoir conditions. To reduce imperfection, it is often preferred to use reservoir parameters rather than injectate properties. In the complete paper, the authors study the effect of injected water on geothermal reservoirs while varying temperature from 14 to 312°C.
Evaluation of Stresses Induced by OT Bridge Prosthetic System with Different Number of Scews in All on Six Maxillary Prosthesis (In Vitro Study)
Authors: Alattar Shymaa Ibrahim abdalaziz , Ouda Shaimaa Lotfy Mohammed , Mohamed Sara Ibrahim Soliman
Published: February 2024

The hazardous stresses that could be induced by missing or broken screws in full-arch implant prostheses and the occasional esthetic need for eliminating screws mandate selecting stable prosthetic systems even with a lack of full screw connection. Using finite element analysis this study aims to evaluate the stresses induced by the OT-bridge system (Rhein83®) in the absence of an entire screw anchorage. After exporting the geometry information of; a CAD/CAM prototype of an edentulous maxilla with six implants, and its framework that will be simulated using OT bridge system “extragrade” abutments to the meshing software, boundary and loading conditions will be set and the analysis will be run under axial load 250 N and non- axial load 150 N at 30° inclination. The average Von Mises stress, and displacement values will be calculated for a number of 43 components of five test groups categorized according to the number and distribution of the applied screws. Data obtained from comparing the groups will be used to determine what is the maximum number of screws that could be eliminated without affecting the prosthetic stability or inducing hazardous stresses.
Metal-organic frameworks for the capture of dissolved CO2 and generated carbonate ions from water
Authors: Wuttke Stefan , Andreo Jacopo , Dutta Subhajit , Barroso Nagore , Ejsmont Aleksander , Baumgartner Bettina , Jankowska Agata , Tittel Jonas , Marcé Rafael , Frankowski Marcin , Weckhuysen Bert M. , Ploetz Evelyn , Goscianska Joanna
Published: February 2024

Anthropogenic CO2 emissions are the major driver of climate change of this century. The natural hydrological cycles cause atmospheric CO2 to be absorbed by the natural water bodies, which necessitates urgent removal of dissolved CO2 and their generated carbonate species from water. Herein, we report the first benchmark study to explore the potentials of the highly porous hybrid material class of metal-organic frameworks (MOFs) for the effective removal of dissolved CO2 and carbonic acid species from water. Seven diverse MOFs with a wide range of structural, and compositional varieties were selected on the basis of their gaseous phase CO2 capture performance. Single component adsorption studies revealed remarkably diverse CO2 removal performances, highlighting key roles of the pH (e.g., 2, 6.3, 8.3, and 10) and the nature of the carbonic species present. Amongst all materials, JUK-8 exhibited the highest adsorption capacity of 6.79 mmol/g toward carbonic acid species at pH 6.3 (CO2 and HCO3¯). Importantly, the MOFs were also found to exhibit substantial removal performance while tested with diverse natural water samples.
Identification of a Unique Subpopulation of Mucosal Fibroblasts in Colorectal Cancer with Tumor- Restraining Characteristics
Authors: Gu Jamin , Jeong Eunjin , Gong Jeong-Ryeol , Cho Kwang-Hyun , Sung Chang Ohk , Kim Seok-Hyung
Published: February 2024

While Tumor-restraining cancer-associated fibroblasts (Tr-CAFs) have been investigated in various cancers, their existence in colorectal cancer remains unexplored. We performed a comprehensive analysis of diverse colorectal cancer datasets, including single-cell RNAseq/ATACseq data from colorectal samples, TCGA RNAseq, and histological samples. We identified a fibroblast subpopulation uniquely expressing ADAMDEC1, CXCL14, EDNRB, and PROCR, strongly associated with favorable patient outcomes, implicating their role as Tr-CAFs. Pseudotime trajectory analysis suggested these cells as terminally differentiated mucosal fibroblasts. Pathway analysis indicated that this subpopulation was significantly associated with tumor-suppressive functions, such as reduced extracellular matrix secretion, augmented immune response and enhanced responsiveness to immunotherapy. Single-cell ATAC-seq analysis revealed that this putative Tr-CAF subset exhibited unique epigenetic profiles characterized by super-enhancer regulated tumor-suppressive genes, thereby supporting its identity as a stable lineage rather than a transient phenotypic state induced by external stimuli. Immunohistochemistry showed that key markers identifying this putative Tr-CAF subset—CXCL14, ADAMDEC1, EDNRB, and PROCR—were predominantly localized to fibroblasts within normal colonic mucosa and less frequently in cancer-associated fibroblasts (CAFs). Their expression levels exhibited statistically significant associations with favorable clinicopathological indicators, including prolonged disease-free survival. Notably, ADAMDEC1 expression in CAFs was significantly correlated with T-cell infiltration within the tumor microenvironment. In conclusion, our investigation elucidates the characteristics and clinical relevance of Tr-CAFs in colorectal cancer, suggesting novel avenues for targeted anti-CAF therapy.
Mitochondrial coding and control region variants are associated with Type-2 Diabetes in Pakistani population
Authors: Farooq Saad , Naqvi Syed Faizan-ul-Hasan , Muhammad Shahid , Piotrowska-Nowaka Agnieszka , Bukhari Syed Ali Raza Shah , Javed Ahsan , Irfan Muhammad , Khan Ishtiaq Ahmad
Published: February 2024

Background
Sequence changes of human mitochondrial DNA (mtDNA) are involved in many human diseases. Mitochondrial DNA variants have been associated with development of type 2 diabetes, which is becoming more prevalent in the Pakistani population. We conducted a case-control study to investigate the role of mtDNA variants associated with diabetes in the Pakistani population.
Results
Analysis of the HVS2 region showed two variants m.309_310insCT and m.315dup were associated with diabetes. By analyzing complete mtDNA, no variant was found to have significantly different distribution between groups. However, comparison of our diabetic samples’ variants with 1000 Genome Project variants showed eight highly significant variations in mitochondrial genome, four in non-coding region i.e. (m.513G > A, m.195T > C, m.16189T > C, m.16265A > C) and four in coding regions i.e. m.9336A > G (CO-III gene), m.11935T > C (ND4 gene), m.14766C > T (CYB gene) and m.7193T > C (CO-I gene) the last one being a rare mitochondrial variant also. We also found one novel variant m.570C > CACCC in the diabetic group.
Conclusion
We found specific variations in the mitochondrial genome are associated with type 2 diabetes in the Pakistani patients. These findings suggest that mtDNA variations may play a role in the development of type 2 diabetes in the Pakistani population.
Gastric Amyloidosis- A Case Report
Authors: Kibria Md.Golam , Khalil Md.Musab , Saha Tanmoy , Hossain Anwar , Gain Gobinda , Miah Shah Alam , Datta Raj , Alam Jan E , Khan Sharmin Tahmina , Akter Dilruba , Islam Mohammad Shahidul , Akhter Tuhin
Published: February 2024

Introduction: Amyloidosis are abnormal misfolded proteins that are resistant to degradation. Due to defective metabolism, they may be deposited in various organs causing organ dysfunction. Localized amyloidosis is a rare disorder.
Case Presentation: We are describing a case of isolated Gastric amyloidosis who presented with recurrent hematemesis and melena due to gastric ulcers. Gastroscopy revealed Multiple Gastric ulcers of variable sizes and shapes. Biopsy followed by histopathology with Congo red staining revealed Gastric amyloidosis.
Conclusion: Amyloidosis is a rare disorder. Localized amyloidosis is much rarer compared to systemic amyloidosis. Compared to systemic amyloidosis, localized amyloidosis has a better prognosis. High level of suspicion is needed to diagnose amyloidosis as a rare case of gastric ulcer.
Associations between metabolic syndrome and allergic diseases: a nationwide study in Korea and literature review
Authors: Kwon Min Jung , An Jihye , Yu Jin Woo , Kim Jung Eun , Bae Youin , Park Young Lip , Moon Jong Youn , Lee Sul Hee
Published: February 2024

Atopic dermatitis (AD), allergic rhinitis (AR), and asthma are typical allergic diseases, with a common pathogenesis involving increased type 2 immunity. Despite numerous studies, the association between these diseases and metabolic syndrome (MetS) remains controversial. This study aimed to explore relationships between AD, AR, and asthma both to MetS and to each of its components. Population-based, cross-sectional data were obtained from the Korean National Health and Nutrition Examination Survey from 2019 to 2020. Multiple logistic regression analyses were conducted to evaluate the association between allergic diseases and MetS. The results were compared with those of previous studies of the association between MetS and allergic diseases, identified in a literature review following a search of PubMed and the Cochrane Library. Based on assessments of 1,329, 4,824, and 1,172 patients with AD, AR, and asthma, respectively, negative associations between both AD and AR and MetS were determined, after adjusting for confounding factors. By contrast, asthma was positively associated with MetS (odds ratio [OR] 0.58, 95% confidence interval [CI] 0.50–0.67; OR 0.73, 95% CI 0.67–0.78; OR 1.70, 95% CI 1.51–1.92, respectively). The heterogeneous findings highlight the need for further investigation of associations between the studied allergic diseases and MetS as well as each of its components.
Air pollution weakens global spring greening
Authors: Wu Chaoyang , Hua Hao , Wang Jian , Dong Lingwen , Zohner Constantin , Penuelas Josep , Wang Yunqi , Zhou Yuyu , Peng Shushi , Zhu Zaichun , Wei Jing , Yuan Wenping , Chen Xiuzhi , Chen Lei , Fu Yongshuo , Li Jialing , Ju Weimin , Zhou Yanlian , Liang Dan , Friedlingstein Pierre , Sitch Stephen , Guo Yuming , Ge Quansheng
Published: February 2024

Climate change is causing widespread land surface greening in spring1–4, but the impacts of anthropogenic air pollution on these changes remain poorly understood. Using global ground and satellite observations of fine particulate matter ≤ 2.5 μm (PM2.5) from 2000 to 2020, here we show that PM2.5 concentration offsets global spring greening as indicated by significant decreases in the normalized difference vegetation index (NDVI), leaf area index (LAI), and solar-induced fluorescence (SIF). Our experiments and meta-analyses involving up to 104 worldwide species reveal that pollution-induced greenness declines are primarily due to physical blockage and damage to leaf stomata. However, factors such as increased diffuse radiation and nitrogen deposition may occasionally enhance greening. Moreover, we observed significant variations among state-of-art terrestrial ecosystem models in replicating these greenness declines, with incorrect representation of PM2.5 effects on vegetation greening for roughly one third of global land coverage, further underscoring the importance of empirical data for benchmarking these models. This study reveals the negative feedback between anthropogenic air pollution and terrestrial carbon uptake, emphasizing the critical need for major polluting countries to mitigate air pollution and CO2 emissions.