bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Different Post-Curing Temperatures on Mechanical and Physical Properties of Waste-Modified Polymer Composites
Authors: Dębska Bernardeta , Almada Bruna Silva , Brigolini Silva Guilherme Jorge
Published: October 2024

One of the key trends affecting the future of the construction industry is the issue of ecology; therefore, current activities in construction aim to reduce the use of raw materials, which is made possible by including recycled materials in composites, among other methods. This article describes the results of tests conducted using four types of epoxy composites, i.e., composites modified with waste rubber (WR), composites modified with waste polyethylene (PE) agglomerate, glycolysate obtained using polyethylene terephthalate (PET) waste, and control unmodified mortars (CUM). Selected properties of the mortars were monitored during their maturation under laboratory conditions, as well as after post-curing at elevated temperatures in the range of 60 °C–180 °C. With the increase in the reheating temperature, an increase in the flexural strength of all types of mortars was noted, with the highest more than twofold stronger than the unmodified composites. The compressive strength increased up to a temperature of 140 °C, and then decreased slightly. The highest value of 139.8 MPa was obtained using PET mortars. Post-curing also led to a slight loss of mass of all samples in the range of 0 to 0.06%. Statistical methods were employed, which made it possible to determine the post-curing temperature and composite composition for which the determined properties are simultaneously the most beneficial, especially for the prefabricated elements.
Analysis of Tribological Properties of Engine Lubricants Used in Hybrid Vehicles
Authors: Skonieczna Daria , Vrublevskyi Oleksandr , Janulin Michał , Szczyglak Piotr
Published: October 2024

A problem has been noted regarding the admixture of fuel to a low viscosity lubricant in hybrid electric vehicles (HEVs). This is very detrimental to the wear and tear of engine operating components. In this study, the operating conditions of HEVs were analysed. Using X-ray fluorescence spectrometry (XRF), engine oils of two different viscosity classes were compared after the operating process and these data were compared with fresh reference samples. Attention was paid to the content of elements such as Ca, Zn, Mo, Sn, Cd, Fe Pb, Si, Cu, and Ni. The depletion of anti-wear additives, as well as the higher content of metallic wear products relative to the operated 5W30 (engine oil), contributed to the overall assessment of the lubricity of the 0W30 oil, as well as to the tribological results. Then, under laboratory conditions, oil samples contaminated with up to 1 to 8% fuel were subjected to rheological (mini AV-X viscometer) and tribological (four-ball tester) tests. The dependence of the local pressure at the metal-to-metal contact point in the kinematic node on viscosity showed the dissimilar nature of the used and fresh oil and the divergence of the domains for the two groups of samples. Increasing the fuel contamination of used oil above 4% drastically reduces the pressure responsible for maintaining the oil film. In order to improve lubricant performance during HEV operation in urban conditions, it was proposed to carry out extra-urban traffic driving in order to evaporate the fuel from the engine oil. A shorter oil change interval is also recommended.
A Novel Triad of Bio-Inspired Design, Digital Fabrication, and Bio-Derived Materials for Personalised Bone Repair
Authors: Dei Rossi Greta , Vergani Laura Maria , Buccino Federica
Published: October 2024

The emerging paradigm of personalised bone repair embodies a transformative triad comprising bio-inspired design, digital fabrication, and the exploration of innovative materials. The increasing average age of the population, alongside the rising incidence of fractures associated with age-related conditions such as osteoporosis, necessitates the development of customised, efficient, and minimally invasive treatment modalities as alternatives to conventional methods (e.g., autografts, allografts, Ilizarov distraction, and bone fixators) typically employed to promote bone regeneration. A promising innovative technique involves the use of cellularised scaffolds incorporating mesenchymal stem cells (MSCs). The selection of materials—ranging from metals and ceramics to synthetic or natural bio-derived polymers—combined with a design inspired by natural sources (including bone, corals, algae, shells, silk, and plants) facilitates the replication of geometries, architectures, porosities, biodegradation capabilities, and mechanical properties conducive to physiological bone regeneration. To mimic internal structures and geometries for construct customisation, scaffolds can be designed using Computer-aided Design (CAD) and fabricated via 3D-printing techniques. This approach not only enables precise control over external shapes and internal architectures but also accommodates the use of diverse materials that improve biological performance and provide economic advantages. Finally, advanced numerical models are employed to simulate, analyse, and optimise the complex processes involved in personalised bone regeneration, with computational predictions validated against experimental data and in vivo studies to ascertain the model’s ability to predict the recovery of bone shape and function.
Transparent and Flexible Hierarchical Porous Structure of Polyvinyl Alcohol Aerogel: A Microstructure Study
Authors: Li Xiaoli , Zhang Xuguang , Zhang Hexiang , Sun Xiao , Mu Ying , Barrett Thomas , Doyle Conor , Minus Marilyn L. , Zheng Yi
Published: October 2024

Aerogels have gained increasing attention due to their unique properties since their introduction in 1932. Silica aerogel, one of the earliest and most advanced types, is known for its high transparency and excellent thermal insulation. However, its internal pearl-like structure makes it extremely brittle, which limits its practical applications. To address this, through multiple refinements in formulation and production techniques, we developed a novel Polyvinyl Alcohol (PVA) aerogel using an innovative one-step standing method. This method significantly reduces the gelling time compared to the freeze–thaw method and eliminates the need for refrigeration, making it a more environmentally friendly and sustainable process. The resulting one-step standing PVA aerogel features a hierarchical porous structure, remarkable transparency, improved strength, and enhanced thermal insulation. Mechanical tests demonstrated that the PVA aerogel produced by the one-step standing method exhibited a significantly higher Young’s modulus of 4.2596 MPa, surpassing that of silica, copper nanowire (Cu NM), and graphene aerogels. Additional tests, including transmittance and thermal analysis, further confirmed that the one-step standing PVA aerogel excels in both transparency and thermal insulation. This combination of improved mechanical performance and light transmission opens novel potential applications, such as drug delivery systems, where the aerogel’s pore structure can store drugs while maintaining strength and transparency.
Design of Shape Forming Elements for Architected Composites via Bayesian Optimization and Genetic Algorithms: A Concept Evaluation
Authors: Kazmer David O. , Olanrewaju Rebecca H. , Elbert David C. , Nguyen Thao D.
Published: October 2024

This article presents the first use of shape forming elements (SFEs) to produce architected composites from multiple materials in an extrusion process. Each SFE contains a matrix of flow channels connecting input and output ports, where materials are routed between corresponding ports. The mathematical operations of rotation and shifting are described, and design automation is explored using Bayesian optimization and genetic algorithms to select fifty or more parameters for minimizing two objective functions. The first objective aims to match a target cross-section by minimizing the pixel-by-pixel error, which is weighted with the structural similarity index (SSIM). The second objective seeks to maximize information content by minimizing the SSIM relative to a white image. Satisfactory designs are achieved with better objective function values observed in rectangular rather than square flow channels. Validation extrusion of modeling clay demonstrates that while SFEs impose complex material transformations, they do not achieve the material distributions predicted by the digital model. Using the SSIM for results comparison, initial stages yielded SSIM values near 0.8 between design and simulation, indicating a good initial match. However, the control of material processing tended to decline with successive SFE processing with the SSIM of the extruded output dropping to 0.023 relative to the design intent. Flow simulations more closely replicated the observed structures with SSIM values around 0.4 but also failed to predict the intended cross-sections. The evaluation highlights the need for advanced modeling techniques to enhance the predictive accuracy and functionality of SFEs for biomedical, energy storage, and structural applications.
Experiments and Modeling of Three-Dimensionally Printed Sandwich Composite Based on ULTEM 9085
Authors: Nowak Radosław , Rodak Dominik , Pytel Stefan , Rumianek Przemysław , Wawrzyniak Paweł , Dębski Daniel Krzysztof , Dudziak Agnieszka , Caban Jacek
Published: October 2024

This article presents the concept, research, and modeling of a sandwich composite made from ULTEM 9085 and polycarbonate (PC). ULTEM 9085 is relatively expensive compared to polycarbonate, and the composite structure made of these two materials allows for maintaining the physical properties of ULTEM while reducing the overall costs. The composite consisted of outer layers made of ULTEM 9085 and a core made of polycarbonate. Each layer was 3D-printed using the fused filament fabrication (FFF) technology, which enables nearly unlimited design flexibility. The geometry of the test specimens corresponds to the ISO 527-4 standard. Tensile and three-point bending tests were conducted. The structure was modeled in a simplified manner using averaged stiffness values, and with the classical laminate theory (CLT). The models were calibrated through tensile and bending tests on ULTEM and polycarbonate prints. The simulation results were compared with experimental data, demonstrating good accuracy. The 3D-printed ULTEM-PC-ULTEM composite exhibits favorable mechanical properties, making it a promising material for cost-effective engineering applications.
Synthesis and Thermal Properties of Bio-Based Janus Ring Siloxanes Incorporating Terpenes and Terpenoids
Authors: Yagafarov Niyaz , Kuang Jiaorong , Takeda Nobuhiro , Liu Yujia , Ouali Armelle , Unno Masafumi
Published: October 2024

A mild and highly selective hydrosilylation method was employed to synthesize five novel well-defined Janus ring siloxanes bearing terpenes and terpenoids, which are the main bioactive components of essential oils. The characterization of these new bio-sourced molecular materials, derived from hydrosilyl-substituted all-cis-cyclotetrasiloxane, was conducted through comprehensive analyses using multinuclear NMR, infrared spectroscopy, elemental analysis, and mass spectroscopy. The thermal stability of the newly synthesized Janus rings was investigated, and the siloxane skeleton was shown to confer an enhanced thermal stability compared with free terpenes and terpenoids.
Weighted Asymmetry Index: A New Graph-Theoretic Measure for Network Analysis and Optimization
Authors: Koam Ali N. A. , Nadeem Muhammad Faisal , Ahmad Ali , Eshaq Hassan A.
Published: October 2024

Graph theory is a crucial branch of mathematics in fields like network analysis, molecular chemistry, and computer science, where it models complex relationships and structures. Many indices are used to capture the specific nuances in these structures. In this paper, we propose a new index, the weighted asymmetry index, a graph-theoretic metric quantifying the asymmetry in a network using the distances of the vertices connected by an edge. This index measures how uneven the distances from each vertex to the rest of the graph are when considering the contribution of each edge. We show how the index can capture the intrinsic asymmetries in diverse networks and is an important tool for applications in network analysis, optimization problems, social networks, chemical graph theory, and modeling complex systems. We first identify its extreme values and describe the corresponding extremal trees. We also give explicit formulas for the weighted asymmetry index for path, star, complete bipartite, complete tripartite, generalized star, and wheel graphs. At the end, we propose some open problems.
Numerical Modeling of Two-Phase Fluid Filtration for Carbonate Reservoir in Two-Dimensional Formulation
Authors: Uzyanbaev Ravil M. , Bobreneva Yuliya O. , Poveshchenko Yury A. , Podryga Viktoriia O. , Polyakov Sergey V. , Rahimly Parvin I. , Gubaydullin Irek M.
Published: October 2024

This work considers the isothermal process of incompressible viscous fluid filtration in an oil-saturated, fractured-porous reservoir. A study of the pressure and water saturation distribution process is carried out for a case in which a production well is put into operation. For this problem, i.e., a mathematical model in a two-dimensional formulation, a numerical method and a parallel algorithm are proposed. The mathematical model of two-phase filtration is written in accordance with the classical laws of continuum mechanics and Darcy’s law and also includes a function of fluid exchange between low-permeability pores and high-permeability natural fractures within the framework of the Warren–Root model. The numerical solution is based on the finite-difference method and a splitting scheme of physical processes and spatial coordinates. For a split system with respect to piezoconductivity, an implicit finite-difference scheme with fixed saturations is constructed, and with respect to saturation transfer, explicit and implicit difference schemes are constructed. For parallel implementation of the developed numerical approach, a method based on geometric parallelism is selected. Testing of the developed method is performed using the example of calculating liquid mass transfer for a wide range of parameters. To verify the model, the obtained calculated pressure curves are compared with field data recorded by a deep-well measuring device. The results allow for estimation of the distribution of reservoir pressure and water saturation depending on the permeability of the fracture set and the pore part. The obtained results allow for monitoring of well operations, reducing unexpected accident risks and optimizing the development system in order to increase oil production in fractured-porous reservoirs. Computational experiments confirm the efficiency of the developed numerical algorithm and its parallel implementation.
Evolutionary Game Analysis of Electric Vehicle Distribution Entities with Shared Charging Facilities
Authors: Xu Guangcan , Chen Jieyu , Yu Dennis Z. , Liu Yong
Published: October 2024

This study investigates the evolutionary game dynamics among electric vehicle distribution entities in the context of shared charging facilities, addressing the critical issue of inadequate charging resources. To understand the behavior of different stakeholders under government incentive policies, we develop an evolutionary game model involving a government department and two logistics enterprises (A and B). Through stability analysis, we explore equilibrium conditions of evolutionarily stable strategies (ESSs) for the tripartite evolutionary game. To ensure the robustness of our findings, we conduct a MATLAB simulation analysis to validate the analytical results. Our findings highlight that government subsidies, the costs incurred by logistics enterprises to share charging facilities, and the additional distribution income derived from this sharing are critical in determining whether the evolutionary game can achieve a stable equilibrium state. This research enables logistics companies to optimize the use of charging resources, lower operating costs, and enhance delivery efficiency. Additionally, government subsidy policies play a crucial role in encouraging logistics enterprises to engage in charging facility sharing, thereby fostering the sustainable development of the entire logistics industry. Based on these insights, the paper offers practical recommendations to further promote the sharing of charging facilities in electric vehicle distribution.
Ulam–Hyers and Generalized Ulam–Hyers Stability of Fractional Differential Equations with Deviating Arguments
Authors: Dilna Natalia , Fekete Gusztáv , Langerová Martina , Tóth Balázs
Published: October 2024

In this paper, we study the initial value problem for the fractional differential equation with multiple deviating arguments. By using Krasnoselskii’s fixed point theorem, the conditions of solvability of the problem are obtained. Furthermore, we establish Ulam–Hyers and generalized Ulam–Hyers stability of the fractional functional differential problem. Finally, two examples are presented to illustrate our results, one is with a pantograph-type equation and the other is numerical.
A Vibrotactile Belt for Measuring Vibrotactile Acuities on the Human Torso Using Coin Motors
Authors: Wang Shaoyi , Dai Wei , Yu Lichao , Liu Yong , Yang Yidong , Guo Ruomi , Hong Yuemin , Chen Jianning , Lin Shangxiong , Ruan Xingxing , Ouyang Qiangqiang , Wang Xiaoying
Published: October 2024

Accurate measurement of the vibrotactile acuities of the human torso is the key to designing effective torso-worn vibrotactile displays for healthcare applications such as navigation aids for visually impaired persons. Although efforts have been made to measure vibrotactile acuities, there remains a lack of systematic studies addressing the spatial, temporal, and intensity-related aspects of vibrotactile sensitivity on the human torso. In this work, a torso-worn vibrotactile belt consisting of two crossed coin motor arrays was designed and a psychophysical study was carried out to measure the spatial, temporal, and intensity-related vibrotactile acuities of a set of human subjects wearing the designed belt. The objective parameters of vibrational intensity and the timing latency of the coin motor were also determined before measuring the vibrotactile acuities. The experimental results indicated that the tested coin motor was able to generate a median number of five and six available just-noticeable differences in intensity and duration, respectively. Among the four parameters of vibrational intensity, the perceived intensity was the most relevant to vibrational displacement. The spatial acuities measured as the degree of two-point spatial thresholds (TPTs) showed less individual difference than the distance TPTs. The results from the current work provide valuable guidance for the design of a comfortable torso-worn vibrotactile display using coin motors.
Five Unreported Ketone Compounds—Penicrustones A–E—From the Endophytic Fungus Penicillium crustosum
Authors: Lin Dongmei , Yang Lian , Yang Jin , Li Feixing , Cui Xiuming , Yang Xiaoyan
Published: October 2024

Five unreported ketone compounds—penicrustones A–E—were isolated from the solid fermentation of the endophytic fungus Penicillium crustosum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography. All compounds were evaluated for their antimicrobial and antitumor activities. Compounds 4 and 5 showed moderate inhibitory effects on Micrococcus luteus, with MIC values of 12.5 and 25.0 μg/mL, respectively. In addition to this, compound 4 also showed cytotoxicity on tumor cell lines KTC-1 and Hela, with IC50 values of 4.28 and 4.64 μg/mL, respectively.
Sequencing and Analysis of Wolbachia Strains from A and B Supergroups Detected in Sylvatic Mosquitoes from Brazil
Authors: da Silva Luísa Maria Inácio , da Silva José Irnaldo , da Silva Alexandre Freitas , Dezordi Filipe Zimmer , Machado Lais Ceschini , Qin Si , Fan Hang , Tong Yigang , Campos Túlio de Lima , Paiva Marcelo Henrique Santos , Wallau Gabriel Luz
Published: October 2024

Wolbachia are endosymbiotic bacteria that infect a wide range of arthropods and filarial nematodes, often manipulating host reproduction. The efficacy of Wolbachia-based interventions for dengue and chikungunya control has been validated through numerous field studies in recent years. This study aimed to investigate the diversity and prevalence of Wolbachia infections in sylvatic mosquitoes from two locations in Recife, Brazil. Multiple mosquito species were screened for Wolbachia using both target marker gene amplification coupled with Sanger sequencing and whole-genome sequencing (WGS) approaches. Phylogenetic analyses were conducted to classify Wolbachia strains into supergroups and assess their evolutionary relationships. Results revealed the presence of Wolbachia in eleven mosquito species examined, with different infection rates. Both supergroups A and B of Wolbachia strains were identified, with Aedes albopictus showing co-infection by both supergroups through the WGS approach. We also detected indirect evidence of Wolbachia horizontal transmission among mosquitoes and other distant host orders. This study provides valuable insights into the distribution and diversity of Wolbachia in sylvatic mosquitoes from Brazil and adds new important data about Wolbachia detection through target marker gene amplicon coupled with Sanger sequencing and WGS methods, highlighting its complementarity to ascertain the presence of Wolbachia in mosquito samples.
Leuconostoc pseudomesenteroides Bacteremia in an Immunocompromised Patient with Hematological Comorbidities—Case Report
Authors: Simoiu Madalina , Filipescu Mihai-Cezar , Omer Meilin , Borcan Alina Maria , Olariu Mihaela-Cristina
Published: October 2024

Leuconostoc pseudomesenteroides is a rare pathogen that can cause bacteremia in immunocompromised patients, particularly those with hematological conditions like acute myeloid leukemia. In this case, a 56-year-old woman developed Leuconostoc bacteremia following chemotherapy and multiple infections, including invasive aspergillosis. Despite broad-spectrum antibiotic treatments, her fever persisted until the blood cultures identified Leuconostoc pseudomesenteroides. Switching to intravenous ampicillin led to the resolution of symptoms. This case highlights the challenges in diagnosing and treating rare, glycopeptide-resistant bacteria in immunosuppressed patients and underscores the importance of repeated blood cultures and automated diagnostic systems. It also highlights the need for more rapid ways of diagnosing and treating such rare infections.
Enhancing Mechanical and Tribological Properties of Epoxy Composites with Ultrasonication Exfoliated MoS2: Impact of Low Filler Loading on Wear Performance and Tribofilm Formation
Authors: Jayasinghe Ravisrini , Ramos Maximiano , Nand Ashveen , Ramezani Maziar
Published: October 2024

This study highlights the impact of low amounts of MoS2 quantities on composite performance by examining the effects of ultrasonication exfoliated MoS2 at different loadings (0.1–0.5 wt%) on the mechanical and tribological parameters of epoxy composites. Even at low concentrations, the ultrasonication and exfoliation procedures greatly improve the dispersion of MoS2 in the epoxy matrix, enabling its efficient incorporation into the tribofilm during sliding. Optimum mechanical properties were demonstrated by the MoS2/epoxy composite at 0.3 wt%, including a modulus of elasticity of 0.86 GPa, an ultimate tensile strength of 61.88 MPa, and a hardness of 88.0 Shore D, representing improvements of 61.5%, 35.45%, and 16.21%, respectively. Corresponding tribological tests revealed that high sliding velocity (10 N load, 0.2 m/s) resulted in a 44.07% reduction in the coefficient of friction and an 86.29% reduction in wear rate compared to neat epoxy. The enhanced tribological performance is attributed to the efficient removal and incorporation of MoS2 into the tribofilm, where it acts as a solid lubricant that significantly reduces friction and wear. Even though an ultra-low amount of filler concentration was added to the composite, a unique finding was the high MoS2 content in the tribofilm at higher sliding speeds, enhancing lubrication and wear protection. This study establishes that even ultralow MoS2 content, when uniformly dispersed, can profoundly improve the mechanical and tribological properties of epoxy composites, offering a novel approach to enhancing wear resistance.
Effect of Thermal Processing on the Structural and Magnetic Properties of Epitaxial Co2FeGe Films
Authors: Vovk Andrii , Popadiuk Dariia , Postolnyi Bogdan , Bunyaev Sergey , Štrichovanec Pavel , Pardo José Ángel , Algarabel Pedro Antonio , Salyuk Olga , Korenivski Vladislav , Kakazei Gleb N. , Golub Vladimir O. , Araujo João Pedro
Published: October 2024

The structure and magnetic properties of epitaxial Heusler alloy films (Co2FeGe) deposited on MgO (100) substrates were investigated. Films of 60 nm thickness were prepared by magnetron co-sputtering at different substrate temperatures (TS), and those deposited at room temperature were later annealed at various temperatures (Ta). X-ray diffraction confirmed (001) [110] Co2FeGe || (001) [100] MgO epitaxial growth. A slight tetragonal distortion of the film cubic structure was found in all samples due to the tensile stress induced by the mismatch of the lattice parameters between Co2FeGe and the substrate. Improved quality of epitaxy and the formation of an atomically ordered L21 structure were observed for films processed at elevated temperatures. The values of magnetization increased with increasing TS and Ta. Ferromagnetic resonance (FMR) studies revealed 45° in-plane rotation of the easy anisotropy axis direction depending on the degree of the tetragonal distortion. The film annealed at Ta = 573 K possesses the minimal FMR linewidth and magnetic damping, while both these parameters increase for another TS and Ta. Overall, this study underscores the crucial role of thermal treatment in optimizing the magnetic properties of Co2FeGe films for potential spintronic and magnonic applications.
Combined Toxicity of Multi-Walled Carbon Nanotubes and Cu2+ on the Growth of Ryegrass: Effect of Surface Modification, Dose, and Exposure Time Pattern
Authors: Xie Wenwen , Peng Cheng , Wang Weiping , Chen Xiaoyi , Tan Jiaqi , Zhang Wei
Published: October 2024

The escalating release of multi-walled carbon nanotubes (MWCNTs) into the environment has raised concerns due to their potential ecotoxicological impacts. However, their combined phytotoxicity with heavy metals such as copper (Cu) is still unclear. This study investigated the individual and combined toxic effects of MWCNTs (MWCNT, MWCNT-OH, and MWCNT-COOH) and Cu2+ on ryegrass (Lolium multiflorum), uniquely considering different addition orders. The results show that Cu severely inhibited the growth of ryegrass while MWCNTs exhibited a hormesis effect on ryegrass. When MWCNT and Cu were combined, the malondialdehyde (MDA) content in ryegrass showed a 32.39% increase at 20 mg/L MWCNT exposure, suggesting reduced oxidative stress. However, at the higher concentration of 1000 mg/L, it led to a significant 75.22% reduction in ryegrass biomass. MWCNT-COOH had the most pronounced effect, reducing the total chlorophyll content by 39.76% compared to unmodified MWCNT and by 10.67% compared to MWCNT-OH (500 mg/L). Additionally, pre-induced MWCNTs might alleviate the Cu in the plant by 23.08–35.38% through adsorption in the nutrient solution. Small molecule organic acids and amino acids primarily mediated the response to environmental stress in ryegrass. This research provides crucial insights into understanding the complex interactions of MWCNT and Cu2+ and their combined effects on plant ecosystems.
Heterogeneous Catalytic Ozonation of Pharmaceuticals: Optimization of the Process by Response Surface Methodology
Authors: Tsiarta Nikoletta , Gernjak Wolfgang , Cajner Hrvoje , Matijašić Gordana , Ćurković Lidija
Published: October 2024

Batch heterogeneous catalytic ozonation experiments were performed using commercial and synthesized nanoparticles as catalysts in aqueous ozone. The transferred ozone dose (TOD) ranged from 0 to 150 μM, and nanoparticles were added in concentrations between 0 and 1.5 g L−1, with all experiments conducted at 20 °C and a total volume of 240 mL. A Ce-doped TiO2 catalyst (1% molar ratio of Ce/Ti) was synthesized via the sol–gel method. Response surface methodology (RSM) was applied to identify the most significant factors affecting the removal of selected pharmaceuticals, with TOD emerging as the most critical variable. Higher TOD resulted in greater removal efficiencies. Furthermore, it was found that the commercially available metal oxides α-Al2O3, Mn2O3, TiO2, and CeO2, as well as the synthesized CeTiOx, did not increase the catalytic activity of ozone during the degradation of ibuprofen (IBF) and para-chlorobenzoic acid (pCBA). Carbamazepine (CBZ) and diclofenac (DCF) are compounds susceptible to ozone oxidation, thus their complete degradation at 150 μM transferred ozone dose was attained. The limited catalytic effect was attributed to the rapid consumption of ozone within the first minute of reaction, as well as the saturation of catalyst active sites by water molecules, which inhibited effective ozone adsorption and subsequent hydroxyl radical generation (●OH).
Development, Content Validity and Usability of a Self-Assessment Instrument for the Lifestyle of Breast Cancer Survivors in Brazil
Authors: de Souza Jaqueline Schroeder , Kliemann Nathalie , Vieira Francilene Gracieli Kunradi , Al Nahas Aline , Reitz Luiza Kuhnen , Aglago Elom Kouassivi , Copetti Cândice Laís Knöner , Vieira Lilian Cardoso , Huybrechts Inge , de Pinho Nivaldo Barroso , Di Pietro Patricia Faria
Published: October 2024

Background/Objectives: Breast cancer is the most common cancer among women globally, and it negatively impacts diet and quality of life, increasing the risk of recurrence. Adhering to World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) lifestyle guidelines, such as healthy eating habits and nutritional status, can help in primary and secondary cancer prevention. However, no questionnaire was found for self-assessment of these guidelines for the Brazilian population. The aim of this study is to carry out content validity, pilot, and usability testing of the self-administered digital instrument “PrevCancer” assessing adherence to the WCRF/AICR recommendations in Brazilian female breast cancer survivors. Methods: We conducted a psychometric study that involved the development of an instrument based on WCRF/AICR recommendations. Assessment of content validity involved the Content Validity Index (CVI) based on expert assessments (n = 7). The pilot study involved the System Usability Scale (SUS) after applying the developed instrument (n = 65) and anthropometric assessment for convergent validity by female participants (n = 55). The final usability test consisted of evaluating the satisfaction with the instrument of women with breast cancer (n = 14). Results: The “PrevCancer” instrument demonstrated good content (CVI = 1.0) as well as good usability and acceptability in the pilot study (mean SUS score = 88.1). The convergent validity stage demonstrated positive associations between the PrevCancer parameters and anthropometric parameters (p < 0.001). In the final usability study (mean SUS score = 90.3), participants’ receptivity to the instrument was excellent. Conclusions: The PrevCancer instrument had valid content and great usability by the target population, proving to be a useful tool for future cancer research.
Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review
Authors: Ansari Prawej , Khan Joyeeta T. , Chowdhury Suraiya , Reberio Alexa D. , Kumar Sandeep , Seidel Veronique , Abdel-Wahab Yasser H. A. , Flatt Peter R.
Published: October 2024

Diabetes mellitus (DM) is currently regarded as a global public health crisis for which lifelong treatment with conventional drugs presents limitations in terms of side effects, accessibility, and cost. Type 2 diabetes (T2DM), usually associated with obesity, is characterized by elevated blood glucose levels, hyperlipidemia, chronic inflammation, impaired β-cell function, and insulin resistance. If left untreated or when poorly controlled, DM increases the risk of vascular complications such as hypertension, nephropathy, neuropathy, and retinopathy, which can be severely debilitating or life-threatening. Plant-based foods represent a promising natural approach for the management of T2DM due to the vast array of phytochemicals they contain. Numerous epidemiological studies have highlighted the importance of a diet rich in plant-based foods (vegetables, fruits, spices, and condiments) in the prevention and management of DM. Unlike conventional medications, such natural products are widely accessible, affordable, and generally free from adverse effects. Integrating plant-derived foods into the daily diet not only helps control the hyperglycemia observed in DM but also supports weight management in obese individuals and has broad health benefits. In this review, we provide an overview of the pathogenesis and current therapeutic management of DM, with a particular focus on the promising potential of plant-based foods.
Improvement in Symptoms of Depression and Anxiety and Cardiometabolic Risk Factors in Children and Adolescents with Overweight and Obesity Following the Implementation of a Multidisciplinary Personalized Lifestyle Intervention Program
Authors: Vourdoumpa Aikaterini , Paltoglou George , Manou Maria , Mantzou Emilia , Kassari Penio , Papadopoulou Marina , Kolaitis Gerasimos , Charmandari Evangelia
Published: October 2024

Background/Objectives: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems, which persist for a long time. The aim of the study was to assess the effect of a multidisciplinary personalized lifestyle intervention for depressive and anxiety symptoms, as evaluated by psychometric questionnaires, and their effect and association with cardiometabolic parameters in children and adolescents with overweight and obesity before and after the intervention. Methods: Six hundred and eleven (n = 611) children and adolescents (mean age ± SE: 10.39 ± 0.10 years; 51.5% females, 46.6% pubertal) were studied prospectively. Subjects were classified as being obese (50.2%), overweight (33.5%), or having a normal BMI (16.2%) according to IOTF criteria. All participants entered a 1-year lifestyle intervention program; laboratory investigations were obtained at the beginning and end of the study and two psychometric questionnaires were completed, the CDI and SCARED, which evaluate symptoms of depression and anxiety, respectively. Results: Following the lifestyle intervention, a significant decrease was noted in anxiety scores in all subjects and in depression scores in youth with obesity, as well as in adolescents with obesity, while females displayed a reduced response to the intervention. Insulin resistance and metabolic syndrome parameters, cortisol, PRL, and LH concentrations were positive predictors for depressive and anxiety symptoms. Conclusions: The implementation of a multidisciplinary personalized lifestyle intervention program in the management of childhood obesity is associated with a significant decrease in cardiometabolic and psychosocial comorbidities in children with and without excess adiposity. The improvement in mental health is likely mediated by an improvement in energy metabolism with subsequent improvement in neuroinflammation owing to lifestyle changes.
Vertical Association Between Dietary Total Choline and L-alpha-glycerylphosphorylcholine and the Cognitive Function in Chinese Adults Aged over 55, Result from China Health and Nutrition Survey 1997–2018
Authors: Guan Fangxu , Jia Xiaofang , Huang Feifei , Zhang Jiguo , Wei Yanli , Li Li , Bai Jing , Wang Huijun
Published: October 2024

Background: With the aging process in China showing an accelerated trend, cognitive decline and impairment have become a major issue in older people. Dietary choline supplement may be a changeable lifestyle to improve this situation. Method: We analyzed 7659 adults aged over 55 in the China Health and Nutrition Survey (CHNS), evaluated cognitive function by the global cognition score, and found the association between cognitive function and dietary intake of total choline or L-alpha-glycerylphosphorylcholine (GPC). Linear and logistic mixed models with three levels were applied to analyze the association between dietary total choline/GPC intake and global cognition score, and the risk of poor cognition. Results: The average dietary intake at baseline was 178.8 mg/d for total choline, and 16.3 mg/d for GPC. After an average follow up of 6.8 years, we found that higher intake of total choline (β = 0.083, 95%CI: 0.046,0.119, p < 0.001) and GPC (β = 0.073, 95%CI: 0.034–0.111, p < 0.001) had positively associated with global cognitive scores. Additionally, higher intake of total choline had a better effect on improving the cognitive function of women (β = 0.092, 95%CI: 0.042–0.142, p < 0.01) and individuals between 55–65 years old (β = 0.089, 95%CI: 0.046–0.132, p < 0.01). However, higher GPC intake had a better effect on the cognitive function of men (β = 0.080, 95%CI: 0.020–0.141, p < 0.05). Higher total choline intake had a protective factor against poor cognition (OR = 0.762, 95%CI: 0.676,0.860, p < 0.001); the protective effect was more pronounced for women (OR = 0.750, 95%CI: 0.639,0.879, p < 0.001) and individuals aged 55–65 (OR = 0.734, 95%CI: 0.636–0.848, p < 0.001). Conclusions: higher dietary choline and GPC intake were beneficial for cognitive function, although we found that higher dietary choline was more effective in improving global cognitive scores at older ages; dietary choline should be supplemented as early as possible in old age to prevent poor cognition.
Differences in Associations of Three Types of Alcoholic Beverages with Age-Related Cognitive Decline in Men
Authors: Grønkjær Marie Stjerne , Flensborg-Madsen Trine , Osler Merete , Sørensen Holger Jelling , Becker Ulrik , Mortensen Erik Lykke
Published: October 2024

Objectives: To investigate the influence of wine, beer, and spirits consumption, respectively, on non-pathological, age-related cognitive decline from young adulthood to late midlife in a large follow-up study of Danish men. Methods: The study includes 2456 middle-aged Danish men from the Lifestyle and Cognition Follow-up study 2015, with information on adult-life consumption (from age 26) of wine, beer, and spirits self-reported in late midlife and age-related cognitive decline assessed using the same validated intelligence test administered in young adulthood and late midlife. Associations were adjusted for consumption of other alcoholic beverages, year of birth, age at follow-up, retest interval, education, young adulthood intelligence, and personality. Results: Most of the men had wine (48%) or beer (42%) as their preferred beverage type. For all three alcoholic beverages, consumption of more than 14 units weekly was associated with a greater decline in unadjusted analyses, but this trend was only significant for wine. In contrast, adjusted models showed that moderate wine and spirits consumption was associated with less decline than abstention for these alcohol types (p = 0.03 for 8–14 units/week of wine and p = 0.03 for 1–7 units/week of spirits). Statistical tests suggested a difference between the estimated effects of consumption of 8–14 units/week of wine and beer on cognitive decline. Conclusions: While patterns of associations were similar across beverages, moderate wine and spirits consumption may mitigate cognitive decline, in contrast with beer. However, the results should be interpreted with caution due to inherent differences between men with different alcoholic beverage preferences.
Triglyceride and Glucose Index as an Optimal Predictor of Metabolic Syndrome in Lebanese Adults
Authors: Haidar Suzan , Mahboub Nadine , Papandreou Dimitrios , Abboud Myriam , Rizk Rana
Published: October 2024

Background: Globally, the prevalence of metabolic syndrome (MetS) is on the rise, especially in Arab countries, which emphasizes the need for reliable ethnic-specific biochemical screening parameters. Methods: Two hundred twenty-one Lebanese adults were enrolled in this cross-sectional study. Biochemical parameters including Homeostasis Model Assessment (HOMA), Triglyceride and Glucose index (TyG), ratio of Triglycerides to High-Density Lipoprotein Cholesterol (TG/HDL-C), Atherogenic Index of Plasma (AIP), and Visceral Adiposity Index (VAI) were assessed for their prediction of MetS. Analysis of covariance, logistic regression, expected-versus-observed case ratio were used to determine model calibration, concordance statistic, area under the receiver operating characteristic curve (AUC) and 95% confidence intervals (CIs), sensitivity, specificity, and negative and positive predictive values (PPV, NPV). Results: The prevalence of MetS was 44.3%. All biochemical parameters were significantly associated with MetS, with a strong model discrimination (c-statistic between 0.77 and 0.94). In both sex categories, TyG best predicted MetS (females: cut-off value, 8.34; males: cut-off value, 8.43) and showed good estimation among females, but overestimation among males. HOMA had the lowest discriminatory power in both sex categories. Conclusions: This study suggests that TyG best predicts MetS, while HOMA has the lowest predictive power. Future larger studies need to focus on harmonizing ethnic specific cut-offs and further validating our results.
The Relationship Between Dance Training Volume, Body Composition, and Habitual Diet in Female Collegiate Dancers: The Intercollegiate Artistic Athlete Research Assessment (TIAARA) Study
Authors: Saenz Catherine , Sanders David J. , Brooks Samantha J. , Bracken Lacey , Jordan Aydan , Stoner Justen , Vatne Emaly , Wahler Marley , Brown Ann F.
Published: October 2024

Background: This study’s purpose was to evaluate the relationship between dance training volume, body composition, and habitual diet in female collegiate dancers. Methods: Thirty-three female collegiate dancers from three dance programs (20.4 ± 1.05 yrs.; 165.4 ± 11.3 cm, BMI 21.3 ± 3.4 kg/m2) participated in “The Intercollegiate Artistic Athlete Research Assessment (TIAARA)” study. We assessed dance training volume, body composition, and habitual diet. Data were analyzed using descriptive statistics (means ± SD). Two-sample t-tests were conducted to compare reported intake values versus sports nutrition recommendations. Two-tailed Pearson correlations (r) were computed for body composition and dietary intake (p < 0.05). Results: Collegiate dancers were enrolled in 16 ± 2.09 semester credits, with 7.7 ± 3.8 credits as dance movement courses and an additional 3.0 ± 1.5 h/week of rehearsal time. Body composition assessments included fat mass (24.4 ± 6.8%), lean mass (LM) (42.4 ± 10.1 kg), and total body water (32.6 ± 4.6 L). Habitual diets reflected a low-calorie diet (1399 ± 648 kcal/d), with ~20% of dancers consuming a very low-calorie diet (≤1000 kcal/d). Dancers reported under-consuming dietary protein (54.3 ± 26.2 g) and carbohydrate (171.8 ± 77.8 g). LM was positively correlated with daily total energy (r = 0.333), fat (r = 0.37), protein (r = 0.349), and leucine intake (r = 0.352). Conclusions: Our findings emphasize the positive effect of adequate nutritional quantity and quality on body composition in female collegiate dancers.
Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy
Authors: Oršolić Nada , Jazvinšćak Jembrek Maja
Published: October 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard cancer therapies often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death and increased drug resistance. Moreover, the use of multiple agents also contributes to added toxicity, resulting in poor treatment outcomes. Cancer cells gradually develop resistance to almost all chemotherapeutics through various mechanisms, such as drug efflux, alterations in drug metabolism and transport, changes in signal transduction pathways, enhanced DNA repair capacity, evasion of apoptosis, increased mutations, reactivation of drug targets, interaction with the cancer microenvironment, cancer cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, and the effect of cancer stem cells (CSCs). Developing new strategies to improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes and enhancing patients’ quality of life. One promising approach involves combining conventional cancer treatments with propolis and its flavonoids. These natural compounds may enhance tumor response to treatment while reducing toxicity. Propolis and its components can sensitize cancer cells to chemotherapeutic agents, likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), and thereby reducing the release of matrix metalloproteinase (MMP)-9, cytokines, chemokines, and the vascular endothelial growth factor (VEGF). By reducing TAMs, propolis and its components may also overcome EMT-mediated chemoresistance, disrupt the crosstalk between macrophages and CSCs, inhibit the maintenance of stemness, and reverse acquired immunosuppression, thus promoting an antitumor response mediated by cytotoxic T-cells. This review highlights the potential of flavonoids to modulate the responsiveness of cancer to conventional treatment modalities. The evidence suggests that novel therapeutic strategies incorporating flavonoids could be developed to improve treatment outcomes. The positive effects of combining propolis with chemotherapeutics include reduced cytotoxicity to peripheral blood leukocytes, liver, and kidney cells. Therefore, polyphenolic/flavonoid components may hold potential for use in combination with chemotherapeutic agents in the clinical treatment of various types of cancers.
Methanolic Extract of the Nutritional Plant (Diospyros kaki Thunb.) Exhibits Anticancer Activity by Inducing Mitochondrial Dysfunction in Colorectal Cancer Cells
Authors: Bianchini Stefano , Bovio Federica , Negri Stefano , Bisson Leonardo , Piccinelli Anna Lisa , Rastrelli Luca , Forcella Matilde , Fusi Paola
Published: October 2024

Background/Objectives: Diospyros kaki, the most widely cultivated species of persimmon, has been long used in traditional medicine since its leaves’ extracts contain high amounts of flavonoids and terpenoids, endowed with several beneficial effects. However, its anticancer activity towards colorectal cancer (CRC) has not been investigated in depth. Methods: The effect of a methanolic extract of D. kaki leaves, rich in kaempferol and quercetin derivatives, have been evaluated on an E705 CRC cell line, representative of most CRC patients, and on SW480 cells, carrying a KRAS-activating mutation. Results: This extract is effective in reducing tumor cells’ viability without affecting the healthy mucosa cell line CCD 841. In fact, Western blot experiments showed its ability to induce apoptosis in cancer cells by increasing oxidative stress and disrupting mitochondrial functionality, as shown by reactive oxygen species measurement and Seahorse analysis. Conclusions: With the aim of increasing healthspan, as well as the substantial societal and macroeconomic costs associated with cancer, our results could pave the way to a role for D. kaki extract in both CRC treatment and prevention.