bluuebunny/crossref_metadata_2025 huggingface dataset:
Oil and gas prediction basing on seismic inversion of elastic properties in Chaoshan depression, south China sea
Authors: Guangjian Zhong , Zhongquan Zhao , Guanghong Tu , Kangshou Zhang , Jing Zhao , Hai Yi , Changmao Feng , Junhui Yu
Published: May 2023

The marine Mesozoic is widely distributed in the northeastern waters of the South China Sea and is an important field for oil-gas exploration in the South China Sea. The Chaoshan Depression is the largest residual depression in this sea. At a previous well, LF35-1-1, no oil and gas have been discovered with then pre-drilling prediction techniques. Post-drill analysis shows that the physical properties of the Mesozoic reservoir are not favorable there. So, in accurate prediction of the oil-gas reservoirs is necessary. Since the drilling at the LF35-1-1, extensive surveys and studies have been carried out which shows a number of favorable trapping structures. In the middle low bulge of the Chaoshan Depression, the DS-A structures found with potential reservoirs, complete trap structures, and dual source hydrocarbon supply on both sides, making it the most favorable zone for oil-gas accumulation. We apply the state of art prediction techniques for it using pre-stack seismic raw gather. The sensitivity analysis results of reservoir physical properties indicate that the difference in P- wave velocity between sand and mudstone is 500 m/s, the difference in density is 0.02 g/cm3, and the Poisson’s ratio ranges between 0.11 and 0.33. The Mesozoic sandstone reservoirs in the Chaoshan Depression have characteristics of high velocity and low Poisson’s ratio, and the P-wave velocity, density, and Poisson’s ratio are the main sensitive parameters for predicting reservoir and its oil-gas bearing properties. The density inversion, P-wave impedance inversion, and S-wave impedance inversion jointly characterize the “wedge-shaped” sand body in the DS-A structural area, with a maximum thickness of over 400 m and an area of ∼130 km2. The overlap of the sand body contour map and Poisson’s ratio inversion results indicates that the “wedge-shaped” sand body is an oil-gas bearing sand body. It can be concluded that pre-stack elastic parameter inversion is an effective method for reservoir prediction in deep-sea no-well exploration areas. It has the characteristics of high signal-to-noise ratio, strong stability and reliability, and high accuracy, which is conducive to reduce the non-uniqueness and uncertainty of seismic inversion. The inversion results predict that the DS-A structure is an oil-gas bearing structure.
The Kulbäcksliden Research Infrastructure: a unique setting for northern peatland studies
Authors: Noumonvi Koffi Dodji , Ågren Anneli M. , Ratcliffe Joshua L. , Öquist Mats G. , Ericson Lars , Tong Cheuk Hei Marcus , Järveoja Järvi , Zhu Wei , Osterwalder Stefan , Peng Haijun , Erefur Charlotta , Bishop Kevin , Laudon Hjalmar , Nilsson Mats B. , Peichl Matthias
Published: May 2023

Boreal peatlands represent a biogeochemically unique and diverse environment in high-latitude landscape. They represent a long-term globally significant sink for carbon dioxide and a source of methane, hence playing an important role in regulating the global climate. There is an increasing interest in deciphering peatland biogeochemical processes to improve our understanding of how anthropogenic and climate change effects regulate the peatland biogeochemistry and greenhouse gas balances. At present, most studies investigating land-atmosphere exchanges of peatland ecosystems are commonly based on single-tower setups, which require the assumption of homogeneous conditions during upscaling to the landscape. However, the spatial organization of peatland complexes might feature large heterogeneity due to its varying underlying topography and vegetation composition. Little is known about how well single site studies represent the spatial variations of biogeochemical processes across entire peatland complexes. The recently established Kulbäcksliden Research Infrastructure (KRI) includes five peatland study sites located less than 3 km apart, thus providing a unique opportunity to explore the spatial variation in ecosystem-scale processes across a typical boreal peatland complex. All KRI sites are equipped with eddy covariance flux towers combined with installations for detailed monitoring of biotic and abiotic variables, as well as catchment-scale hydrology and hydrochemistry. Here, we review studies that were conducted in the Kulbäcksliden area and provide a description of the site characteristics as well as the instrumentation available at the KRI. We highlight the value of long-term infrastructures with ecosystem-scale and replicated experimental sites to advance our understanding of peatland biogeochemistry, hydrology, ecology, and its feedbacks on the environment and climate system.
Integration of nurse-led virtual reviews with growth hormone device-linked patient adherence information: a mixed methods feasibility study
Authors: Stokes Helen , Jones Julie , Worth Chris , Nicholson Jacqueline , Fullwood Catherine , Banerjee Indraneel
Published: May 2023

Introduction

Easypod-connect™ for childhood growth disorders is a unique connected system that enables transmission of injection adherence information for recombinant human growth hormone (r-hGH). Although this system has the potential to facilitate greater adherence, observational studies have shown declining adherence over prolonged periods when used without additional support. Supplemental nurse practitioner support has been envisaged but not investigated; in this study, we have undertaken feasibility analysis of nurse-led virtual reviews (NVR) in combination with easypod-connect™ in a single centre using quantitative and qualitative analyses.

Aims

We aimed to test feasibility by assessing compliance with NVR, height standard deviation score (SDS) gain, adherence improvement and patient opinions.

Methods

Patients using easypod™ r-hGH were recruited prospectively to a 12-month study with two telephone NVR appointments in addition to standard of care in-person hospital outpatient visits. A subset was recruited for a semi-structured interview for qualitative thematic analysis.

Results

Forty-three patients of median (range) age 10.7 (6.7, 15.2) were recruited for a period of 1.1 (0.7, 1.8) years. Thirty-three (76.7%) patients were fully compliant with NVR integration with easypod-connect™, establishing feasibility. Median (inter-quartile range, IQR) height SDS improved from -1.85 (-2.44, -1.37) to -1.48 (-2.14, -1.07) (p<0.001) while adherence remained similar in the majority from study start [96.5 (88.8, 100.0)] to end [99.0 (94.0, 100.0)]. Qualitative analysis identified themes supporting patient benefit: practicalities of appointments, perceived purpose and significance of virtual reviews, and the importance of optimising growth. Four patients complained of injection pain, of whom two switched to an alternative r-hGH device.

Conclusion

Our study has demonstrated the feasibility of nurse-led virtual review integration with easypod-connect™ in a mixed methods study, laying the foundation for research in larger groups over longer periods. Nurse practitioner supported application of easypod-connect™ offers the potential for improved growth outcomes in all r-hGH devices providing adherence information.
Trends of the burden of type 2 diabetes mellitus attributable to high body mass index from 1990 to 2019 in China
Authors: Wang Jianglin , Zhou Lingyun , Yin Wenjun , Hu Can , Zuo Xiaocong
Published: May 2023

Background

Overweight and obesity are well-known risk factors for developing type 2 diabetes (T2DM). However, details on the evolution of the T2DM burden attributed to China’s high body mass index (BMI) in China have not been thoroughly studied. This study aimed to investigate the temporal trends of the T2DM burden attributable to a high BMI in China from 1990 to 2019 and to evaluate the independent effects of age, period, and cohort on the burden of T2DM attributed to a high BMI.

Methods

Data on T2DM burden attributable to a high BMI from 1990 to 2019 were obtained from the Global Burden of Disease Study 2019. Deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of T2DM attributable to a high BMI were estimated by age and sex. The joinpoint regression model was performed to calculate the annual percentage change (APC) and the average annual percentage change (AAPC) in the burden of T2DM attributed to a high BMI. The age–period–cohort analysis was applied to estimate the independent effects of age, period, and cohort on the temporal trends of mortality and the DALY rate.

Results

In 2019, deaths and DALYs from T2DM attributable to a high BMI in China were 47.53 thousand and 3.74 million, respectively, five times higher than in 1990. Among those under 60 years of age, men had higher deaths and DALYs than women, while the gender differences reversed in those over 60 years of age. Furthermore, the ASMR and ASDR in 2019 were 2.39 per 100,000 (95%UI 1.12–3.90) and 181.54 per 100,000 (95%UI 93.71–286.33), respectively, representing a 91% and 126% increase since 1990. In China, women previously had a higher ASMR and ASDR than men, while the differences in the ASMR and ASDR between the sexes were reversed in recent years. From 1990 to 2019, the ASMR in women increased before 2004 and then decreased from 2004 to 2015, and increased again after, with an overall AAPC value of 1.6%. In contrast, the ASMR in men continued to increase, with an overall AAPC value of 3.2%. The ASDR continued to increase in men and women, with AAPCs of 2.2% and 3.5%, respectively. The age effect showed that the relative risk of mortality increased with age in both men and women, except for the 75–84 age group. The impact of the age on the DALY rate revealed a trend of first rising and then decreasing, peaking at 65–69 years. The effect of the period on the burden of T2DM attributable to a high BMI increased from 1990 to 2019. The cohort effect generally showed a downward trend.

Conclusion

The burden of T2DM attributed to a high BMI in China increased substantially from 1990 to 2019, particularly in men. Therefore, there is an urgent need for gender- and age-based public health guidelines on prevention strategies, early diagnosis, and effective management of T2DM, overweight, and obesity in China.
Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms
Authors: Crescenzi Anna , Baloch Zubair
Published: May 2023

The use of immunohistochemistry cannot be underestimated in the everyday practice of thyroid pathology. It has evolved over the years beyond the traditional confirmation of thyroid origin to molecular profiling and the prediction of clinical behavior. In addition, immunohistochemistry has served to implement changes in the current thyroid tumor classification scheme. It is prudent to perform a panel of immunostains, and the immunoprofile should be interpreted in light of the cytologic and architectural features. Immunohistochemistry can also be easily performed in the limited cellularity specimen preparation generated from thyroid fine-needle aspiration and core biopsy; however, it will require laboratory validation of immunostains specific to these preparations to avoid diagnostic pitfalls. This review discusses the application of immunohistochemistry in thyroid pathology with a focus on limited cellularity preparations.
Wind tunnel test study on the wind load variation law of a point focus solar furnace
Authors: He Mingfei , Huang Penglin , Gong Bo , Zang Chuncheng , Wang Zhifeng
Published: May 2023

This work studied the wind load acting on a point focus solar furnace composed of a 110 m2 heliostat and a 77 m2 concentrator through wind tunnel testing. Based on wind tunnel test data under 305 different working conditions, the variation laws of the wind pressure coefficient, power spectral density, and wind load coefficient of the heliostat and concentrator were analyzed. The results showed that due to the interaction between the concentrator and heliostat, the wind speed near the heliostat and concentrator decreased but the turbulence intensity increased, which caused the peak wind load coefficient to rise slightly. The results suggested that a safety factor of 1.1–1.2 should be considered for structural design and optimization of solar furnaces.
On the role of energy infrastructure in the energy transition. Case study of an energy independent and CO2 neutral energy system for Switzerland
Authors: Schnidrig Jonas , Cherkaoui Rachid , Calisesi Yasmine , Margni Manuele , Maréchal François
Published: May 2023

The transition towards renewable energy is leading to an important strain on the energy grids. The question of designing and deploying renewable energy technologies in symbiosis with existing grids and infrastructure is arising. While current energy system models mainly focus on the energy transformation system or only investigate the effect on one energy vector grid, we present a methodology to characterize different energy vector grids and storage, integrated into the multi-energy and multi-sector modeling framework EnergyScope. The characterization of energy grids is achieved through a traditional energy technology and grid modeling approach, integrating economic and technical parameters. The methodology has been applied to the case study of a country with a high existing transmission infrastructure density, e.g., Switzerland, switching from a fossil fuel-based system to a high share of renewable energy deployment. The results show that the economic optimum with high shares of renewable energy requires the electric distribution grid reinforcement with 2.439 GW (+61%) Low Voltage (LV) and 4.626 GW (+82%) Medium Voltage (MV), with no reinforcement required at transmission level [High Voltage (HV) and Extra High Voltage (EHV)]. The reinforcement is due to high shares of LV-Photovoltaic (PV) (15.4 GW) and MV-wind (20 GW) deployment. Without reinforcement, additional biomass is required for methane production, which is stored in 4.8–5.95 TWh methane storage tanks to compensate for seasonal intermittency using the existing gas infrastructure. In contrast, hydro storage capacity is used at a maximum of 8.9 TWh. Furthermore, the choice of less efficient technologies to avoid reinforcement results in a 8.5%–9.3% cost penalty compared to the cost of the reinforced system. This study considers a geographically averaged and aggregated model, assuming all production and consumption are made in one single spot, not considering the role of future decentralization of the energy system, leading to a possible overestimation of grid reinforcement needs.
Seasonal variation of ecosystem photosynthetic capacity and its environmental drivers in global grasslands
Authors: Chen Xiuzhi , Ren Xiaoli , He Honglin , Zhang Li , Lv Yan
Published: May 2023

Ecosystem maximum photosynthetic rate (Amax) is an important ecosystem functional property, as it is critical for ecosystem productivity modeling. However, little is known about the mechanisms that regulate the seasonal variation of Amax in grasslands, one of the dominant vegetation types worldwide. In this study, we analyzed the seasonal variability of Amax of grassland sites across the globe and its environmental drivers. We found that grassland Amax had strong seasonal variations, which were influenced by the climate and agricultural management, such as grass cutting and grazing. Second, the seasonal variation of Amax at all arid grasslands [mean annual vapor pressure deficit (VPD) > 10 hPa] was driven more by changes in canopy physiological property (i.e., maximum photosynthetic rate per leaf area Amaxa) than canopy structural property (i.e., leaf area, presented by LAI), because Amaxa had stronger temporal variability than LAI in these ecosystems. Third, temperature and VPD were the most influential factors for the seasonal variability of Amax and LAI, but environmental variables only explained a small proportion of the seasonal variation of Amaxa, which was probably because Amaxa was more related to plant traits. Our findings provide new ideas for better parameterizations of Amax in terrestrial ecosystem models.
The application of clinical variable-based nomogram in predicting overall survival in malignant phyllodes tumors of the breast
Authors: Li Wei , Fang Kun , Chen Jiaren , Deng Jian , Li Dan , Cao Hong
Published: May 2023

Background: We aimed to explore prognostic risk factors in patients with malignant phyllodes tumors (PTs) of the breast and construct a survival prediction model.

Methods: The Surveillance, Epidemiology, and End Results database was used to collect information on patients with malignant breast PTs from 2004 to 2015. The patients were randomly divided into training and validation groups using R software. Univariate and multivariate Cox regression analyses were used to screen out independent risk factors. Then, a nomogram model was developed in the training group and validated in the validation group, and the prediction performance and concordance were evaluated.

Results: The study included 508 patients with malignant PTs of the breast, including 356 in the training group and 152 in the validation group. Univariate and multivariate Cox proportional hazard regression analyses showed that age, tumor size, tumor stage, regional lymph node metastasis (N), distant metastasis (M) and tumor grade were independent risk factors for the 5-year survival rate of patients with breast PTs in the training group (p < 0.05). These factors were used to construct the nomogram prediction model. The results showed that the C-indices of the training and validation groups were 0.845 (95% confidence interval [CI] 0.802–0.888) and 0.784 (95% CI 0.688–0.880), respectively. The calibration curves of the two groups were close to the ideal 45° reference line and showed good performance and concordance. Receiver operating characteristic and decision curve analysis curves showed that the nomogram has better predictive accuracy than other clinical factors.

Conclusion: The nomogram prediction model constructed in this study has good predictive value. It can effectively assess the survival rates of patients with malignant breast PTs, which will aid in the personalized management and treatment of clinical patients.
Characterization of HSP70 family in watermelon (Citrullus lanatus): identification, structure, evolution, and potential function in response to ABA, cold and drought stress
Authors: Wang Xinsheng , Jin Zhi , Ding Yina , Guo Meng
Published: May 2023

Watermelon (Citrullus lanatus) as a crop with important economic value, is widely cultivated around the world. The heat shock protein 70 (HSP70) family in plant is indispensable under stress conditions. However, no comprehensive analysis of watermelon HSP70 family is reported to date. In this study, 12 ClHSP70 genes were identified from watermelon, which were unevenly located in 7 out of 11 chromosomes and divided into three subfamilies. ClHSP70 proteins were predicted to be localized primarily in cytoplasm, chloroplast, and endoplasmic reticulum. Two pairs of segmental repeats and 1 pair of tandem repeats existed in ClHSP70 genes, and ClHSP70s underwent strong purification selection. There were many abscisic acid (ABA) and abiotic stress response elements in ClHSP70 promoters. Additionally, the transcriptional levels of ClHSP70s in roots, stems, true leaves, and cotyledons were also analyzed. Some of ClHSP70 genes were also strongly induced by ABA. Furthermore, ClHSP70s also had different degrees of response to drought and cold stress. The above data indicate that ClHSP70s may be participated in growth and development, signal transduction and abiotic stress response, laying a foundation for further analysis of the function of ClHSP70s in biological processes.
Transoral incisionless fundoplication and open hiatal hernia repair: A case report
Authors: Turaga Anjani H. , Salem Yasser H.
Published: May 2023

Introduction

Transoral incisionless fundoplication is a new procedure that has recently emerged as a potential alternative to traditional anti-reflux surgeries. It is a less invasive option with fewer complications and reduced recovery time. Hiatal hernia repair is also commonly performed in conjunction with transoral incisionless fundoplication to improve outcomes. In this case, it details a successful transoral incisionless fundoplication and hiatal hernia repair procedure in a patient with long standing gastroesophageal reflux disease (GERD). The case is unique as it involved a patient with an uncharacteristically large hiatal hernia measuring above 5cm, which is a size that is generally not considered suitable for transoral incisionless fundoplication. The hiatal hernia was repaired with a gastrectomy instead of laparoscopically due to the size and adhesions present.

Case details

This case report presents an 86 year old female patient with a history of long-standing GERD symptoms from the past 10 years who had failed to respond to medical therapy. Endoscopic imaging revealed a hernia of more than 5cm in size, which was confirmed by a bravo study. A DeMeester score of 446 was reported. The patient was referred for surgery and underwent transoral incisionless fundoplication with hiatal hernia repair. Despite the large size of the hiatal hernia, it was decided to proceed with a transoral incisionless fundoplication (TIF) procedure combined with hiatal hernia repair. The gastrectomy was chosen due to significant adhesions and anatomical distortion, making it difficult to continue laparoscopically. The esophagus was fibrosed to the pericardium, and the stomach was stuck in a retrocardiac position. Laparoscopic removal of the adhesions proved difficult since the patient had friable tissues, and there was a high risk of injury to surrounding organs. The surgery was therefore converted to an open approach, and the hernia was repaired with a gastrectomy. The TIF procedure was performed successfully, and the patient had no complications postoperatively.

Conclusion

This case details a successful transoral incisionless fundoplication procedure for GERD in a patient with an uncharacteristically large hiatal hernia. Despite the challenges posed by the hernia’s size and anatomical distortion, the TIF procedure combined with hiatal hernia repair was successful in providing relief from GERD symptoms, with no postoperative complications. The case highlights the potential suitability of TIF as an alternative to laparoscopic fundoplication in patients with large hiatal hernias, although gastrectomy may be necessary in cases with significant adhesions or anatomical distortion.
Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis
Authors: Kou Haiyang , Huang Lei , Jin Meng , He Qi , Zhang Rui , Ma Jianbing
Published: May 2023

Objective

The aim of this study is to evaluate the effectiveness and safety of curcumin in rheumatoid arthritis patients.

Methods

A computerized search from PubMed, Embase, Cochrane Library, and Web of Science databases was performed until 3 March 2023. Literature screening, basic data extraction and risk of bias evaluation were independently performed by two researchers each. The quality evaluation of the literature was performed according to the Cochrane Handbook for Risk of Bias Assessment tool for treatment evaluation.

Results

The current study includes six publications covering 539 rheumatoid arthritis patients. The activity of rheumatoid arthritis was assessed using erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), protein, disease activity score (DAS), rheumatoid factor (RF), Visual Analogue Scale (VAS) pain, tender joint count (TJC) and swollen joint count (SJC). ESR (MD = -29.47, 95% CI [-54.05, -4.88], Z=2.35, P = 0.02), DAS28 (MD = -1.20, 95% CI [-1.85, -0.55], Z=3.62, P = 0.0003), SJC (MD = -5.33, 95% CI [-9.90, -0.76], Z = 2.29, P = 0.02) and TJC (MD = -6.33, 95% CI [-10.86, -1.81], Z = 2.74, P = 0.006) showed significantly change in experimental patients compared with controls.

Conclusion

Curcumin is beneficial for rheumatoid arthritis treatment. Inflammation levels and clinical symptoms in patients with rheumatoid arthritis can be improved by curcumin supplementation. Large sample randomized controlled trials on the effects of curcumin on patients with rheumatoid arthritis are needed in the future.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42022361992).
Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population
Authors: Khor Seik-Soon , Ueno Kazuko , Nishida Nao , Kawashima Minae , Kawai Yosuke , Aiba Yoshihiro , Hitomi Yuki , Nagasaki Masao , Nakamura Minoru , Tokunaga Katsushi
Published: May 2023

Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex. Three-field-resolution HLA imputation of 1,670 Japanese PBC patients and 2,328 healthy controls was conducted using Japanese population-specific HLA reference panels. Eighteen previously reported Japanese PBC-associated HLA alleles were confirmed and extended to 3-field-resolution, including HLA-DRB1*08:03 to HLA-DRB1*08:03:02, HLA-DQB1*03:01 to HLA-DQB1*03:01:01, HLA-DQB1*04:01 to HLA-DQB1*04:01:01 and HLA-DQB1*06:04 to HLA-DQB1*06:04:01. In addition, additional significant novel HLA alleles were identified, including 3 novel susceptible HLA-DQA1 alleles: HLA-DQA1*03:03:01, HLA-DQA1*04:01:01, HLA-DQA1*01:04:01 and 1 novel protective HLA-DQA1 allele, HLA-DQA1*05:05:01. In addition, PBC patients carrying HLA-DRB1*15:01:01 and HLA-DQA1*03:03:01 would have a higher predisposition toward developing concomitant autoimmune hepatitis (AIH). Further, late-stage and symptomatic PBC shared the same susceptible HLA alleles of HLA-A*26:01:01, HLA-DRB1*09:01:02 and HLA-DQB1*03:03:02. Lastly, HLA-DPB1*05:01:01 was identified as a potential risk HLA allele for development of hepatocellular carcinoma (HCC) in PBC patients. In conclusion, we have extended the current knowledge of HLA allele associations to 3-field resolution and identified novel HLA allele associations with predisposition risk, staging, symptomatic state, and AIH and HCC events for Japanese PBC patients.
The role of inflammatory biomarkers in the development and progression of pre-eclampsia: a systematic review and meta-analysis
Authors: Guan Xiaohan , Fu Yanwen , Liu Yixin , Cui Mingxuan , Zhang Caishun , Zhang Qing , Li Chunmei , Zhao Jian , Wang Chaofan , Song Jiarun , Dong Jing
Published: May 2023

Background

Pre-eclampsia (PE) is a pregnancy complication associated with maternal and fetal morbidity and mortality. Among the potential pathogenesis discussed, inflammation is considered an essential initiator of PE. Previous studies have compared the levels of various inflammatory biomarkers that indicate the existence of PE; however, the relative levels of pro-inflammatory and anti-inflammatory biomarkers and their dynamic changes during PE progression remain unclear. This knowledge is essential to explain the occurrence and progression of the disease.

Objective

We aimed to identify the relationship between inflammatory status and PE using inflammatory biomarkers as indicators. We also discussed the underlying mechanism by which inflammatory imbalance contributes to PE by comparing the relative levels of pro-inflammatory and anti-inflammatory biomarkers. Furthermore, we identified additional risk factors for PE.

Methods

We reviewed PubMed, Embase, and the Cochrane Library for articles published until 15th September 2022. Original articles that investigated inflammatory biomarkers in PE and normal pregnancy were included. We selected healthy pregnant women as controls. The inflammatory biomarkers in the case and control groups were expressed as standardized mean differences and 95% confidence intervals using a random-effects model. Study quality was assessed using the Newcastle-Ottawa Scale. Publication bias was assessed using Egger’s test.

Results

Thirteen articles that investigated 2,549 participants were included in this meta-analysis. Patients with PE had significantly higher levels of C-reactive protein (CRP), interleukin (IL)-4, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF) than the controls. CRP and pro-inflammatory cytokine levels were higher than those of anti-inflammatory cytokines. Patients with gestational age > 34 weeks had significantly higher IL-6 and TNF levels. Patients with higher systolic blood pressure had significantly higher IL-8, IL-10, and CRP levels.

Conclusion

Inflammatory imbalance is an independent risk factor for PE development. Impairment of the anti-inflammatory system is a crucial initiating factor for PE development. Failed autoregulation, manifested as prolonged exposure to pro-inflammatory cytokines, leads to PE progression. Higher levels of inflammatory biomarkers suggest more severe symptoms, and pregnant women after 34 weeks of gestation are more susceptible to PE.
Differential expression and correlation of immunoregulation related piRNA in rheumatoid arthritis
Authors: Ren Ruyu , Tan Huiling , Huang Zhuochun , Wang Yuanyi , Yang Bin
Published: May 2023

Background

Although PIWI-interacting RNAs (piRNAs) have recently been associated with germline development and many human diseases, their expression pattern and relationship in autoimmune diseases remain indistinct. This study aimed to investigate the presence and correlation of piRNAs in rheumatoid arthritis (RA).

Methods

We first analyzed the expression profile of piRNAs using small RNA sequencing in peripheral leukocytes of three new-onset untreated RA patients and three healthy controls (HCs). We then selected piRNAs related to immunoregulation by bioinformatics analysis and verified them in 42 new-onset RA patients and 81 HCs by RT-qPCR. Furthermore, a receiver operating characteristic curve was generated to quantify the diagnostic performance of these piRNAs. A correlation analysis was conducted to observe the link between piRNA expression and RA clinical characteristics.

Results

A total of 15 upregulated and 9 downregulated piRNAs among 1,565 known piRNAs were identified in peripheral leukocytes of RA patients. Dysregulated piRNAs were enriched in numerous pathways related to immunity. After selection and validation, two immunoregulation piRNAs (piR-hsa-27620 and piR-hsa-27124) were significantly elevated in RA patients and have good abilities to distinguish patients from controls, which have the potential to serve as biomarkers. PIWI and other proteins implicated in the piRNA pathway were also associated with RA.
Therapy response in seronegative versus seropositive autoimmune encephalitis
Authors: Berger Benjamin , Hauck Sophie , Runge Kimon , Tebartz van Elst Ludger , Rauer Sebastian , Endres Dominique
Published: May 2023

Background

Autoimmune encephalitis (AE) might be seropositive or seronegative, depending on whether antibodies targeting well-characterized neuronal antigens can be detected or not. Since data on treatment efficacy in seronegative cases, are scarce, the main rationale of this study was to evaluate immunotherapy response in seronegative AE in comparison to seropositive cases.

Methods

An electronic database search retrospectively identified 150 AE patients, treated in our tertiary care university hospital between 2010 and 2020 with an AE. Therapy response was measured using both general impression and the modified Rankin Scale (mRS).

Results

Seventy-four AE patients (49.3%) were seronegative and 76 (50.7%) seropositive. These cases were followed up for a mean of 15.3 (standard deviation, SD, 24.9) and 24.3 months (SD 28.1), respectively. Both groups were largely similar on the basis of numerous clinical and paraclinical findings including cerebrospinal fluid, electroencephalography, magnetic resonance imaging, and 18-F-fluor-desoxy-glucose-positron-emmission-tomography pathologies. The majority of patients (80.4%) received at least one immunotherapy, which were glucocorticoids in most cases (76.4%). Therapy response on general impression was high with 49 (92.5%) of treated seronegative, and 57 (86.4%) of treated seropositive AE cases showing improvement following immunotherapies and not significantly different between both groups. Notably, the proportion of patients with a favorable neurological deficit (mRS 0-2) was twice as high during long-term follow-up as compared to baseline in both groups.

Conclusion

Since both, patients with seronegative and seropositive AE, substantially benefitted from immunotherapies, these should be considered in AE patients irrespective of their antibody results.
Etiology, effects and management of comorbidities in multiple sclerosis: recent advances
Authors: Marrie Ruth Ann , Fisk John D. , Fitzgerald Kathryn , Kowalec Kaarina , Maxwell Colleen , Rotstein Dalia , Salter Amber , Tremlett Helen
Published: May 2023

Comorbid conditions commonly affect people with multiple sclerosis (MS). Population-based studies indicate that people with MS have an increased incidence of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders as compared to people without MS. People with MS from underrepresented minority and immigrant groups have higher comorbidity burdens. Comorbidities exert effects throughout the disease course, from symptom onset through diagnosis to the end of life. At the individual level, comorbidity is associated with higher relapse rates, greater physical and cognitive impairments, lower health-related quality of life, and increased mortality. At the level of the health system and society, comorbidity is associated with increased health care utilization, costs and work impairment. A nascent literature suggests that MS affects outcomes from comorbidities. Comorbidity management needs to be integrated into MS care, and this would be facilitated by determining optimal models of care.
Per-length biomass estimates of Antarctic krill (Euphausia superba)
Authors: Smith Abigail J. R. , Wotherspoon Simon J. , Cox Martin J.
Published: May 2023

Total biomass and areal biomass density are often necessary to establish ecological relationships and enable informed management decisions, in particular setting fisheries catch limits. Further refining these estimates to sub-population biomass based on length informs ecological models of predator-prey dynamics, ecosystem energy transfer and biogeochemical cycles; however, measures of uncertainty in these per-length biomass estimates are needed. We present a statistical method to calculate the per-length biomass of Antarctic krill (Euphausia superba) from conversion factors using acoustic and net sample data. Variability in krill length-frequency, and wetmass introduced by net sampling is also explored through non-parametric bootstrapping. We applied this method on a 1 mm length window to active acoustic and net sample data collected during an Antarctic krill biomass survey in CCAMLR Division 58.4.2 (62 – 67°S; 55 – 80°E, with a survey area of 775,732 km2) performed between February – March 2021. We found that 77% of the total estimated biomass was attributable to krill of length 14 – 49 mm. The largest biomass of krill in a single length bin was estimated as 340,000 t (95% CI: 148,000 - 408,000 t) and was found in the 49 mm length bin (i.e., 48.5 to 49.5 mm). This method will allow future surveys (with sufficient data) to estimate biomass of krill on a per-length basis along with associated uncertainty (confidence intervals) derived from net sampling and so may be used to provision size-based ecosystem models with krill biomass.
Shrinking of the Arabian Sea oxygen minimum zone with climate change projected with a downscaled model
Authors: Vallivattathillam Parvathi , Lachkar Zouhair , Lévy Marina
Published: May 2023

In Arabian Sea (AS), land-locked northern boundary and strong seasonal productivity lead to the formation of one of the most intense open ocean Oxygen Minimum Zones (OMZs). Presence of this perennial OMZ has significant consequences on adjacent coastal fisheries and ecosystem. Simulations from CMIP5 suggest significant weakening of both monsoonal winds and productivity under high emission scenario. But the fate of AS OMZ in this scenario - whether it will expand or shrink - still remains elusive, mainly due to poor representation of extent and strength of AS OMZ in CMIP5 present-day simulations. To address this, we analyze the distribution of O2 in AS from a subset of three contrasted CMIP5 simulations, and complemented with a set of regional downscaled model experiments which we forced at surface and open boundaries using information from those three CMIP5 models. We tested two regional downscaling approaches - with and without correction of CMIP5 biases with respect to observations. Using a set of sensitivity experiments, we disentangle the contributions of local (atmospheric) forcing vs. remote (at the lateral boundaries) forcing in driving the future projected O2 changes. While CMIP5 projects either shrinking or expansion of the AS OMZ depending on the model, our downscaling experiments consistently project a shrinking of AS OMZ. We show that projected O2 changes in OMZ layer are affected by both local and remote processes. In the southern AS, the main response to climate change is oxygenation that originates from the boundaries, and hence downscalled and CMIP5 model responses are similar. In contrast, in northern AS, downscaling yields a substantial reduction in O2 projection discrepancies because of a minimal influence of remote forcing there leading to a stronger sensitivity to improved local physics and improved model representation of present-day conditions. We find that when corrected for present-day biases, projected deoxygenation in the northern AS is shallower. Our findings indicate the importance of downscaling of global models in regions where local forcing is dominant, and the need for correcting global model biases with respect to observations to reduce uncertainties in future O2 projections.
Plant trait-mediated drag forces on seedlings of four tidal marsh pioneer species
Authors: Steinigeweg Charlotte S. , Löbel Swantje , Schröder Boris , Schoutens Ken , Reents Svenja , Evans Ben R. , Temmerman Stijn , Bouma Tjeerd J. , Möller Iris , Paul Maike
Published: May 2023

Salt marshes play an important role in coastal protection by reducing the impact of waves and shoreline erosion risks. While mature vegetation is responsible for the persistence and stability of marsh ecosystems, seedling survival of pioneer species is especially crucial for marsh propagation. Marsh seedlings, however, may be threatened by climate change induced increased coastal storm surge intensity and accompanying (extreme) wave conditions, imposing stronger drag forces on marsh seedlings. We test the hypothesis that drag forces experienced by seedlings increase with horizontal orbital velocity (Uw) in a species-specific manner, and that the drag forces experienced are individual-plant trait-mediated. To test our hypotheses, seedlings of four contrasting pioneer marsh species (Bolboschoenus maritimus, Schoenoplectus tabernaemontani, Spartina anglica, and Puccinellia maritima) were exposed to storm wave conditions in a flume, where Uw and experienced drag forces were measured. Linear mixed effect models demonstrated that seedling’s susceptibility to storm wave conditions is at least partly mediated by individual plant traits. Drag forces experienced by seedlings tended to increase with Uw, and with stem length and diameter. The interplay of both traits was complex, with increasing stem length being the most important trait accounting for increases in drag forces experienced at low to moderate Uw, while the stem diameter became more important with increasing Uw. Furthermore, experienced drag forces appeared to be affected by species-specific traits such as rigidity and leaf growth, being highest for Bolboschoenus maritimus and lowest for Puccinellia maritima. Our results provide important mechanistic insights into the drivers of tidal marsh seedling vulnerability to storm wave conditions due to experienced drag, both based on the traits of individual plants and species-specific ones. This type of knowledge is of key importance when modelling saltmarsh establishment and resilience under climate change.
Decades performance of marine science and education by region and discipline in China
Authors: Hua Tianran , Ruan Xiao , Qu Ziyu , Xue Cheng , Yang Shengyun , Yao Yanming , Ye Guanqiong
Published: May 2023

Strengthening scientific research, technological capacity and sustainable use of oceans in developing countries are the goals of the UN’s 2030 Agenda for Sustainable Development. Marine science and education as the key foundation for achieving these goals has been seldom evaluated quantitatively and collectively. This paper adopted the DEA modelling from economics for analyzing the long-term input and output performance of marine science and education at a national scale in China both by region and discipline. It is found that China’s marine science and education level has been improving annually in the last decade. The input/output efficiency of science and education in 11 coastal provinces however has slightly declined except Guangdong. The input/output performance among 14 research disciplines was further evaluated and was found the similar improving trends. The input/output efficiency of 70% research disciplines showed an increasing trend while 30% of which showed a slightly declining trend. The results could provide important references for prioritizing the science and education resources allocation both in different coastal regions and marine research disciplines to save the investment and achieve more progress.
A flexible bearing plate based on steel plate and rubber mat
Authors: Hou Gui , Zheng Guozhi , Zhang Naitian
Published: May 2023

The bearing plates used in plate load test for highway engineering are typically rigid. However, due to limitations in obtaining the accurate distribution of compressive stress at the bottom of the bearing plate, there is often a significant deviation between the measured subgrade resilient modulus and the actual condition. To address this issue, a flexible bearing plate can be used to test the subgrade and obtain a more accurate resilient modulus. In this study, we use variance and degree of mean deviation to quantitatively evaluate the distribution uniformity of compressive stress. To create a rigid-flexible bearing plate that is similar to a flexible bearing plate, we explore the combinatorial design of steel plates and rubber mats. We examine factors such as the thickness (10, 20, and 30 mm) of the steel plate, elastic modulus (5, 10, and 20 MPa) and thickness (10, 20, and 30 mm) of the rubber mat, friction coefficient (μ:0, 0,2, 0.4, 0.6, 0.8, ∞) between the bearing plate and subgrade, and the combined shape characteristics of the rubber mat and steel plate. To reduce friction between the rubber mat and subgrade, we use lubricant, and through our design process, we develop a flexible bearing plate with relatively uniform compressive stress. Our computations show that when μ = 0.05, the variance is 0.0001, and the degree of mean deviation is 0.0780. These results indicate that the distribution uniformity of the compressive stress is very close to the uniform distribution load, which meets the necessary accuracy requirements for engineering applications.
Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis
Authors: Reiterer Christian , Fleischmann Edith , Kabon Barbara , Taschner Alexander , Kurz Andrea , Adamowitsch Nikolas , von Sonnenburg Markus Falkner , Fraunschiel Melanie , Graf Alexandra
Published: May 2023

Background

Supplemental oxygen leads to an increase in peripheral vascular resistance which finally increases systemic blood pressure in healthy subjects and patients with coronary artery disease, heart failure, undergoing heart surgery, and with sepsis. However, it is unknown whether this effect can also be observed in anesthetized patients having surgery. Thus, we evaluated in this exploratory analysis of a randomized controlled trial the effect of 80% versus 30% oxygen on intraoperative blood pressure and heart rate.

Methods

We present data from a previous study including 258 patients, who were randomized to a perioperative inspiratory FiO2 of 0.8 (128 patients) versus 0.3 (130 patients) for major abdominal surgery. Continuous arterial blood pressure values were recorded every three seconds and were exported from the electronic anesthesia record system. We calculated time-weighted average (TWA) and Average Real Variability (ARV) of mean arterial blood pressure and of heart rate.

Results

There was no significant difference in TWA of mean arterial pressure between the 80% (80 mmHg [76, 85]) and 30% (81 mmHg [77, 86]) oxygen group (effect estimate −0.16 mmHg, CI –1.83 to 1.51; p = 0.85). There was also no significant difference in TWA of heart rate between the 80 and 30% oxygen group (median TWA of heart rate in the 80% oxygen group: 65 beats.min−1 [58, 72], and in the 30% oxygen group: 64 beats.min−1 [58; 70]; effect estimate: 0.12 beats.min−1, CI –2.55 to 2.8, p = 0.94). Also for ARV values, no significant differences between groups could be detected.

Conclusion

In contrast to previous results, we did not observe a significant increase in blood pressure or a significant decrease in heart rate in patients, who received 80% oxygen as compared to patients, who received 30% oxygen during surgery and for the first two postoperative hours. Thus, hemodynamic effects of supplemental oxygen might play a negligible role in anesthetized patients.

Clinical Trail Registration

https://clinicaltrials.gov/ct2/show/NCT03366857?term=vienna&cond=oxygen&draw=2&rank=1
The parasites of my rival are my friends
Authors: Orlansky Sigal , Ben-Ami Frida
Published: May 2023

The competitive exclusion principle asserts that two species cannot stably coexist in the same habitat. However, the presence of a parasite can facilitate temporary coexistence between two host species occupying the same habitat. Studies of parasite-mediated interspecific competition typically use two host species that are both susceptible to a single parasite species, as it is rare to find a resistant host species that requires a parasite to enable coexistence with a competitively superior susceptible host. We therefore investigated how two host species characterized by different susceptibility profiles affect each other when they coexist in the same habitat, by conducting two long-term mesocosm experiments in the laboratory. We followed populations of Daphnia similis coexisting with Daphnia magna, in either the presence or absence of the microsporidium Hamiltosporidium tvaerminnensis and then the bacterium Pasteuria ramosa. We found that in the absence of parasites, D. magna competitively excluded D. similis within a short period of time. However, in the presence of either parasites, the competitive ability of D. magna decreased dramatically. Our results emphasize the importance of parasites in shaping community structure and composition, by allowing coexistence of a resistant host species that would otherwise become extinct.