bluuebunny/crossref_metadata_2025 huggingface dataset:
The Moderating Effect of Gender on the Relationship Between Self-neglect and Suicidal Ideation in Older Adults of Korea
Authors: Jeong Kyuhyoung , Jang Daeyeon , Nam Boyoung , Kwon Soyoung , Seo Eunsol
Published: August 2022

Objectives: Previous studies have reported that self-neglect, which may be a sign of elder abuse, can result in suicide among older adults. The signs of self-neglect and its impact on the risk of suicide may differ by gender. Thus, this study explored the association between self-neglect and suicide risk in older Korean adults and examined the potential moderating effect of gender on this relationship.Methods: Data were collected from 356 Korean adults aged 65 or older through an online survey. Multiple regression analysis was used to test the research hypothesis. First, the associations between 4 sub-dimensions of self-neglect (i.e., daily life management issues, personal hygiene issues, financial management issues, and relational issues) and suicidal ideation were examined. Then, the moderating effect of gender on these relationships was investigated by including interaction terms.Results: Self-neglect was significantly associated with suicidal ideation in older adults. Aspects of self-neglect related to daily life management and relational factors were key predictors of suicidal ideation. Gender significantly moderated the effect of the relational dimension of self-neglect on suicidal ideation. The relational dimension of self-neglect was more strongly associated with suicidal ideation in older women than in older men.Conclusions: The findings suggest the importance of screening older adults with signs of self-neglect for suicide risk. Special attention should be paid to older women who experience relational issues as a high-risk group for suicidal ideation. Public programs and support systems should be established to improve daily life management and promote social relationships among older adults.
Substantive Social Metaphysics
Authors: Taylor Elanor
Published: August 2022

Social metaphysics is a source of important philosophical and moral insight. Furthermore, much social metaphysics appears to be substantive. However, some have recently argued that standard views of metaphysics cannot accommodate substantive social metaphysics. In this paper I offer a new diagnosis of this problem and defend a new solution, showing that this problem is an illuminating lens through which to examine the nature and boundaries of metaphysics. This case instantiates a broad, common pattern generated by attempts to align distinctions between realism and anti-realism, mind-independence and mind-dependence, and legitimate and non-legitimate inquiry. I show that the best response is to abandon the association between substantive metaphysics and mind-independence, and I sketch a new definition of substantivity, given in terms of explanatory power, that makes room for substantive social metaphysics while also offering an attractive basis for general metaphysics.
Adopting IFRS as a Moderating Variable on the Relationship Between Accounting Information and Market Responses
Authors: Deef Alaa , Radi Mohamed Sami
Published: August 2022

The purpose of this paper is to examine the impact of adopting International Financial Reporting Standards (IFRS) on the relationship between accounting information and market responses. We investigate the impact of the IFRS adoption on financial statements quality and whether this impact, if any, has a positive implication of the capital market (especially, market liquidity and equity value). Data were collected from 147 non- financial firms listed on the Saudi exchange for the period 2015-2019. The findings show that disclosure quality has increased because of IFRS adoption. Moreover, the results find that the adoption of IFRS improves market liquidity and increases the share price of firms listed on the Saudi exchange. Our findings show that adopting IFRS have positive economic implications on the Saudi business environment.
Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life – a meta-analysis of randomized, placebo-controlled trials
Authors: Kardos Peter , Lehmacher Walter , Zimmermann Andrea , Brandes-Schramm Juliette , Funk Petra , Matthys Heinrich , Kamin Wolfgang
Published: August 2022

Background: Cough is a leading symptom of viral acute respiratory infections such as acute bronchitis (AB) and the common cold (CC), which can be debilitating and may persist for several weeks. We investigated whether treatment with Pelargonium extract EPs 7630 may reduce cough and improve disease-related quality of life (QoL).Methods: We performed a meta-analysis of randomized, placebo-controlled trials investigating the efficacy of EPs 7630 in AB or CC. Efficacy analyses included change from baseline in a cough intensity score, remission of cough, and disease-associated impairments of QoL.Results: Data of 2,195 participants from 11 trials (3 in children/adolescents with AB, 3 in adults with AB, 5 in adults with CC) were eligible. In children/adolescents with AB, 79.6% of participants treated with EPs 7630 and 41% treated with placebo showed a reduction in intensity of cough by at least 50% of baseline values at day 7 [meta-analysis rate/risk ratio (RR), EPs 7630 / placebo: 1.86 (95% CI: 1.34; 2.95)], and 18.0% vs 5.5% presented with complete remission of cough [RR: 2.91 )95% CI: 1.26; 6.72)]. In adults with AB, 88.7% of participants in the EPs 7630 group and 47.6% in the placebo group showed a ≥50% response for cough intensity [RR: 2.13 (95% CI: 1.37; 3.31)], while 26.0% vs 6.3% did not cough any more at day 7 [RR: 5.00 [95% CI: 3.10; 8.07)]. Cough scale results were supported by significant improvements over placebo in the pursuit of normal daily activities and other QoL measures. In CC, 56.8% of participants treated with EPs 7630 and 38.8% treated with placebo showed a ≥50% cough intensity reduction [RR: 1.40 (95% CI: 1.19; 1.65)] at day 5, while 26.1% versus 18.4% showed complete remission of cough for EPs 7630 and placebo, respectively [RR: 1.40 (95% CI: 1.06; 1.84)]. CC-associated pain/discomfort and an impairment of usual activities were no longer present in 41.5% and 48.8% of participants treated with EPs 7630 compared to less than 40% of patients in the placebo group. Conclusions: The results show that EPs 7630 reduces the burden and leads to earlier remission of cough. Advantages for EPs 7630 were also reflected in self-rated measures of disease-associated QoL. Of note, patients treated with the herbal product felt able to resume their usual daily activities sooner.
Novel pyriproxyfen based treatment for Aedes breeding control through a long-lasting formulation
Authors: Tilak Rina , Wankhede Urmila , Mukherjee Reema
Published: August 2022

Background & objectives: There is a need to evaluate novel techniques for dengue control in India. Several formulations of pyriproxyfen have been assessed for efficacy and duration of action. Pyriproxyfen is also used as a microencapsulated ready-to-use formulation against the Aedes vector. We evaluated a novel pyriproxyfen-based microencapsulated formulation. This slow-release, ready-to-use aqueous spray is a larvicidal formulation, and we assessed its efficacy and residual action through laboratory and semi-field trials against Aedes immature stages.

Methods: The study was carried out as per the guidelines for laboratory and field/small-scale field testing of mosquito larvicides by the World Health Organization. The evaluation was conducted in laboratory and semi-field conditions from August to December 2018. We tested the novel formulation on three materials (plastic, ceramic, and enamel) in the laboratory for its action as an antilarval. Four containers of each kind were sprayed with the formulation and kept as replicates. Four controls were used in the laboratory trials - 120 larvae (third instar) were introduced in the replicates and the controls each. Readings were taken daily till complete adult emergence or larval and pupal mortality. In the semi-field trials, we applied this formulation to the inside of desert coolers and observed larvicidal and pupicidal activity over five months. Data is presented in numbers and percentages, along with mean and standard deviation. Adult emergence and Emergence Inhibition was calculated.

Results: There was 100% adult emergence inhibition amongst the exposed larvae in the treated containers in the laboratory trials. In the untreated controls, adult emergence ranged from 80–95% in all types of containers. In the semifield trials, Inhibition Emergence was 100% in the treated desert coolers during the five months of the study period.

Interpretation & conclusion: This advancement in insecticide formulation technology promises to make dengue control more effective and efficient.
Biological toxicity of Ruta graveolens essential oil against three species of diptera Drosophila melanogaster, Culex pipiens and Culiseta longiareolata
Authors: Bouabida Hayette , Dris Djemaa
Published: August 2022

Background & objectives:

Recently, the use of biodegradable and environment friendly plant-based bioinsecticides has received a great deal of attention from researchers to control insect disease vectors. The aim of this research is to determine the larvicidal efficacy of Ruta graveolens essential oil against third instar larvae of two species of mosquito (Culex pipiens and Culiseta longiareolata) and a biological model Drosophila melanogaster.

Methods:

Culiseta longiareolata and Culex pipiens larvae were collected from untreated areas located in Tebessa and Drosophila melanogaster, the wild strain collected from rotten apples in the Tebessa region. Ruta graveolens essential oil has been tested at different concentrations between 2.5μ/mL and 140μL/mL against third instar larvae of the three species under standard laboratory conditions according to the recommendations from the Word Health Organization. The effects were examined on mortality, growth and the main components (proteins, carbohydrates, lipids).

Results:

The essential oil showed larvicidal activity with LC50 and LC90 values (10.85μL/mL, 70.95μL/mL and 39.4μL/mL), (26μL/mL, 144.5μL/mL and 89.57μL/mL) against third instar larvae of Drosophila melanogaster, Culex pipiens and Culiseta longiareolata respectively. In addition, it disrupted the growth and several morphological malformations were observed. It also affected growth and the main components (proteins, carbohydrates, lipids).

Interpretation & conclusion:

The essential oil affected growth and energy reserves for all three species. The results indicated that the essential oil of Ruta graveolens has good potential as a source of natural larvicides.
Biomarkers
Authors: Firdous Parveena , Nissar Kamran , Masoodi Shariq Rashid , Ganai Bashir Ahmad
Published: August 2022

Maturity Onset Diabetes of Young (MODY), characterized by the pancreatic b-cell dysfunction, the autosomal dominant mode of inheritance and early age of onset (often ≤25 years). It differs from normal type 1 and type 2 diabetes in that it occurs at a low rate of 1-5%, three-generational autosomal dominant patterns of inheritance and lacks typical diabetic features such as obesity. MODY patients can be managed by diet alone for many years, and sulfonylureas are also recommended to be very effective for managing glucose levels for more than 30 years. Despite rapid advancements in molecular disease diagnosis methods, MODY cases are frequently misdiagnosed as type 1 or type 2 due to overlapping clinical features, genetic testing expenses, and a lack of disease understanding. A timely and accurate diagnosis method is critical for disease management and its complications. An early diagnosis and differentiation of MODY at the clinical level could reduce the risk of inappropriate insulin or sulfonylurea treatment therapy and its associated side effects. We present a broader review to highlight the role and efficacy of biomarkers in MODY differentiation and patient selection for genetic testing analysis.
Efficacy and Safety of Novel Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in the Management of Diabetic Kidney Disease
Authors: Dutta Deep , Surana Vineet , Bhattacharya Saptarshi , Aggarwal Sameer , Sharma Meha
Published: August 2022

Background:

Data are scant on use of finerenone in diabetic kidney disease (DKD). We undertook this meta-analysis to address this knowledge gap.

Methods:

Electronic databases were searched for randomized controlled trials (RCTs) involving diabetes patients receiving finerenone compared to controls. The primary outcome was changes in urine albumin-creatinine ratio (UACR). Secondary outcomes were time to kidney failure (decline in GFR by >40% from baseline over 4 weeks), time to end-stage kidney disease, hospitalization for any cause, death and adverse events reported.

Results:

From initially screened 79 articles, data from 7 RCTs involving 13,783 patients were analyzed (3 in active control group [ACG] defined as having eplerenone/spironolactone as active comparator; 4 in passive control group [PCG] defined as having placebo as controls). Patients receiving finerenone had greater percentage lowering of UACR from baseline as compared to PCG [MD23.82% (95%CI: –24.87 to –22.77); P < 0.01; I
2 = 96%] at 90 days, after 2 years [MD 37.9% (95%CI: –38.09 to –37.71); P < 0.01] and 4 years [MD 25.20%(95%CI: –25.63 to –24.77);P < 0.01] of treatment. Patients receiving finerenone has lower chance of >40% decline in GFR (OR 0.83 [95%CI: 0.75 to 0.92];P < 0.01; I
2 = 0%). Patients receiving finerenone had lower occurrence of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for heart failure, as compared to placebo/eplerenone (OR0.86 [95%CI: 0.78 to 0.95]; P = 0.003; I
2 = 0%). TAEs was similar (RR0.97 [95%CI: 0.88–1.07]; P = 0.56; I
2 = 0%), but SAEs significantly lower (RR0.91 [95%CI: 0.84 to 0.97]; P < 0.01; I
2 = 0%) in finerenone-group compared to controls.

Conclusion:

This meta-analysis provides reassuring data on beneficial impact of finerenone in reducing UACR and GFR decline as compared to placebo. We still lack head-to-head comparison of renal outcomes of finerenone vs eplerenone/spironolactone in DKD.
A Rare Presentation of Multifocal Anaplastic Oligodendroglioma
Authors: Reddy Ravikanth
Published: August 2022

Multifocal tumors are usually reported within the same cerebral hemisphere due to widespread dissemination along the white matter tracts. This case report describes the magnetic resonance imaging appearances of multifocal anaplastic oligodendroglioma in a 28-year-old adult male that showed three discrete heterogeneously enhancing cortical-based lesions in the left frontoparietal lobes. Left frontal craniotomy was performed and biopsy of the lesion was obtained, histopathology of which showed features of anaplastic oligodendroglioma.
Role of p63 in Determining the Histogenesis of Low-Grade Neoplasms versus Cystic Lesion
Authors: Aggarwal Dipanshu , Yadav Shefali , Jain Anshi , Shetty Devi Charan
Published: August 2022

The biological nature of salivary gland neoplasms and the overlapping characteristics that result from the heterogeneity of the cells of origin make diagnosis difficult. Hence, we intend to present a case of low grade mucoepidermoid carcinoma (MEC) on the palate and to understand the importance of biomarker such as p63 in the early diagnosis of tumor as it also has a role in its histogenesis. A 53-year-old female reported with a unilateral swelling for 3 months on posterolateral palatal region of the right side. Clinical differentials for such palatal swellings include a varied spectrum of lesions such as reactive, benign, and malignant lesions. Based on the incisional and excisional biopsy, histopathological findings and immunohistochemical examination with p63 the case were diagnosed with low grade MEC. The tumor cell differentiation in MEC could be the result of multiplicity of differentiation pathways leading to the formation of various histological patterns. This case report highlights the complexity of salivary gland pathology diagnosis and role of specific tumor marker such as p63 as an early marker for differentiation of salivary gland tumor such as low grade MEC from other cystic lesions occurring on the palate.
Топологическая классификация потоков без гетероклинических траекторий на связной сумме многообразий $\mathbb{S}^{n-1}\times \mathbb{S}^{1}$
Authors: Grines Vyacheslav Zigmuntovich , Gurevich Elena Yakovlevna
Published: August 2022

In this paper, we announce a result on the possibility of obtaining sufficient conditions for topological conjugacy of gradient-like flows without heteroclinic intersections, given on a connected sum of products $S^{n-1}\times S^1$ in combinatorial terms.
Functional state of regulatory CD4+T cell pool in HIV/hepatitis C virus coinfected subjects
Authors: Saidakova Evgeniya V. , Korolevskaya L. B. , Shmagel K. V.
Published: August 2022

Coinfection with HIV and hepatitis C virus (HCV) leads to development of systemic inflammation associated with increased risk for liver, kidney and cardiovascular diseases, as well as higher mortality from AIDS-associated and non-AIDS-associated illnesses. To a large extent, systemic inflammation is controlled by regulatory T lymphocytes, a subset of CD4+ T cells. While expressing various functional molecules, regulatory CD4+T cells limit functional activity of immunocytes and prevent the development of excessive inflammatory reactions and autoimmune diseases. At the same time, there are no available data in literature concerning the sizes of certain functionally active regulatory CD4+T cell subsets in HIV/HCV coinfected patients. Our aim was to estimate the size of functional pool of the regulatory CD4+T lymphocytes in HIV/ HCV coinfected patients receiving antiretroviral therapy.
Two groups of HIV-positive patients were examined: 1) HIV/HCV coinfected subjects (n = 21); 2) HIV mono-infected patients (n = 22). The control group included voluntary blood donors without HIV and HCV infections (n = 23). Regulatory CD4+T lymphocytes were identified by multicolor flow cytometry based on the expression of the following markers: CD3, CD4, CD25, CD127, and FoxP3. Functional subsets of regulatory CD4+T cells were discerned by the expression of CD39, GARP, LAP, and CD71 molecules. Relative and absolute counts of suppressor CD4+T lymphocytes were calculated for each subset. TGF-1 concentrations in blood plasma were determined with ELISA technique.
Absolute counts of regulatory CD4+T lymphocytes in peripheral blood of HIV/HCV coinfected patients proved to be twice lower than in healthy subjects, while being not accompanied by a decrease in relative frequency of these cells. Despite their deficiency, the number of functionally active CD39-positive,
GARP/LAP-positive, and CD71-positive suppressor cells in HIV/HCV coinfected persons remained at the level found in HIV-monoinfected and healthy people. The frequency of functionally active regulatory CD4+T lymphocytes was increased in HIV/HCV coinfected patients compared with HIV-monoinfected (CD39+, GARP+LAP+) and healthy (CD39+, GARP+LAP+, CD71+) subjects.
In HIV/HCV coinfected patients receiving antiretroviral therapy, the pool of regulatory CD4+T lymphocytes is rich in cells possessing high suppressive capacity. However, the absolute number of functionally active regulatory CD4+T cells remain at the level corresponding to healthy individuals, thus, apparently, is not sufficient to control the systemic inflammation developing in HIV/HCV coinfection.
Immune-hormonal imbalance in chemical cancerogenesis
Authors: Glushkov Andrew N.
Published: August 2022

The present article deals with experimental and clinical aspects of immuno-hormonal interactions in chemical carcinogenesis i.e., formation of DNA-adducts with chemical carcinogens as a trigger of tumor initiation; synthesis of specific antibodies as markers of human exposure to environmental carcinogens; immunomodulation of chemical carcinogenesis by the specific antibodies in experimental studies; interactions of antibodies against environmental carcinogens with endogenous steroid hormones in human carcinogenesis; immunological interference and inversion of immuno-hormonal interactions by the action of antibodies against environmental carcinogens; immune stimulation of tumor progression in cancer patients. It is shown that antibodies specific to estradiol and progesterone participate in regulation of serum estradiol and progesterone levels in healthy women. Excessive production of antibodies against benzo[a]pyrene is associated with impaired physiological balance between the levels of antibodies to estradiol and progesterone, thus causing disturbed physiological balance between serum estradiol and progesterone. Immuno-hormonal imbalance promotes tumor initiation, its growth and progression. The new approaches to the personalized cancer immunoprediction and immune prevention are discussed. Coordinated synthesis of antibodies against benzo[a]pyrene and estradiol seems to reflect production of DNA-adducts with genotoxic metabolic effects of these compounds manifesting as synergistic carcinogenic effects upon the target cells. Hence, simultaneously increased levels of serum antibodies against benzo[a]pyrene and estradiol in healthy people may be considered an immunological marker of high oncological risk and an reason to use of new immunoprotective tools against polycyclic aromatic hydrocarbons and phytoestrogens. However, ability of these antibodies to raise the blood serum levels of environmental carcinogens and endogenous estradiol, as shown in vitro and in vivo, excludes the opportunity for active cancer immune prevention. Usage of anticarcinogen vaccines aimed for induction of protective secretory antibodies is likely to further increase high levels of procarcinogenic serum antibodies against benzo[a]pyrene and estradiol, followed by additional enhancement of immuno-hormonal imbalance and promotion of carcinogenesis. Development of probiotics transduced with genes encoding human antibodies against environmental carcinogens may present an alternative approach to cancer immune prevention. The antibodies produced by such probiotics would bind appropriate carcinogens and prevent their invasion into the organism, thus inhibiting emergence of DNA-adducts and suppressing synthesis of specific autoantibodies that may promote carcinogenesis. The aim is to substantiate the concept of immuno-hormonal imbalance for the carcinogen-induced hormone-dependent tumors.
Macrophages in gouty inflammation
Authors: Malyshev I. Yu. , Chernysheva O. O. , Kuznetsova L. V. , Pikhlak A. E.
Published: August 2022

Gout disorder is likely to be the most common cause of inflammatory arthritis. Hyperuricemia leads to formation of poorly soluble crystalline urate salts in tissues and joints, thus being etiological factor of the gout. The review summarizes modern views on the mechanisms of autoinflammation in gout disorder and it provides an outlook for the new treatment approaches. Inflammation in gout is related to phagocytosis of the urate crystals and the macrophagic NLRP3 inflammosome activation. This process consists of preliminary stage and proinflammatory cytokine generation phases. During the preliminary phase, soluble and crystalline urate salts initiate mRNA transcription for IL-1 and other proinflammatory cytokines precursors in macrophages, synthesis of NLRP3 inflammosome components, and formation of immune memory. Enhanced transcription of IL-1 and other cytokine precursors is implemented via PRAS49-AKT-mTOR signaling, IL- 1ra anti-inflammantory factor and TLR-MyD88-IRAK-NF-B pathway; the enhanced synthesis of NLRP3 inflammasome components provided via the TLR-NF-B pathway. The immune memory develops due to the epigenetic modifications, associated with (de-) acetylation and (de-) methylation of histones and DNA. During the next phase, the effect of soluble and crystalline urate salts upon macrophages promotes NLRP3 inflammosome activation, due to the following events: 1. К+, Cl- and Са2+ ionic currents shift; 2. lysosomic and mitochondrial damage, leading to the cathepsin B release and enhancement of reactive oxygen production, respectively; 3. NLRP3 relocation between the endoplasmic reticulum, Golgi complex and cytosol; 4. alteration of the NLRP3 structure due to auxiliary proteins attachment, phosphorylation, ubiquitination and acetylation. The NLRP3 inflammosome activity results into increased caspase 1 production which, in turn, produces IL-1 and pyroptotic pores proteins. The pyroptotic pores allow IL-1 passage, which further amplifies inflammation. During the pyroptosis, soluble and crystalline urate salts release from the cells, further increasing inflammation and tissue damage. Understanding the mechanisms of gout-associated inflammation helps us to formulate promising approaches to development of novel treatments. Macrophages are the key cells to crystal-induced inflammation development. Thus, new biothechnologies based on macrophage engineering may appear to be prospective in gout treatment. In this review, we have analyzed the prospects of M3 phenotype macrophages (AB-M3) usage in therapy, unlike M1 and M2 phenotypes, is able to produce anti-inflammatory cytokines in response to the inflammatory factors and, therefore, to inhibit crystal-induced inflammation. Meanwhile, unlike the anti-IL-1 medications, e.g., canakinumab, targeting a single end product of the gout inflammation (IL-1), AB-M3 macrophages inhibit not only IL-1 production, but also a group of other inflammatory cytokines.
Killer cell cluster immunity state in adult patients with common variable immunodeficiency
Authors: Prokopovich Svetlana  S. , Novikova I. A.
Published: August 2022

The subpopulation spectrum of killer cluster lymphocytes in peripheral blood was assessed by flow cytometry in combination, along with analysis of clinical manifestations in 30 adult patients (12 males and 18 females, mean age 37.512.3 years) diagnosed with common variable immunodeficiency (CVID). All the patients were observed at the Department of Immunopathology and Allergology at the State Institution Republican Scientific and Practical Center of Radiation Medicine and Human Ecology (Gomel, Republic of Belarus). The diagnosis was based on clinical and laboratory criteria developed by the European Society for Immunodeficiencies, using Common Variable Immunodeficiency Diagnostic Criteria, 2020. The patients were examined in the apparent absence of infectious inflammatory disease, prior to monthly immunoglobulin injections. The control group consisted of 30 healthy subjects, comparable in age and sex with the patients cohort, free of clinical and laboratory signs of immunological insufficiency. The patients with CVID had a reduced content of NK cells (CD3-CD16+CD56+) and CD3-CD8+ lymphocytes in peripheral blood (p% = 0.009, rabs = 0.03 and p%, abs 0.001 respectively), along with increase of T cytotoxic cells and NKT lymphocytes (CD3+CD8+; p% = 0.02, rabs = 0.009 and CD3+CD16+CD56+; p%, 0.001, rabs = 0.004, respectively). Severe NK cell lymphopenia showed inverse correlation with the numbers of T cyclers (rs% = -0.545, p = 0.03), activated T cytotoxic lymphocytes (CD3+CD8+CD38+; rs% = -0.38, p = 0.04), and directly correlated with CD3-CD8+ cell counts (rs% = 0.481, p = 0.008). We also revealed a correlation between the parameters of killer lymphocyte cluster (CD3-CD16+CD56+, CD3-CD8+, CD3+CD16+CD56+) and severity of clinical manifestations in CVID patients. The most pronounced changes in the killer cell subpopulations were observed in patients with a combined clinical phenotype infection syndrome + autoimmune syndrome and infection syndrome + autoimmune syndrome + enteropathy. Thus, the marked changes of killer cell subpopulations manifesting as decreased counts of NK cells and CD3-CD8+ lymphocytes, along with increased NKT lymphocytes and T killer numbers are associated with more severe clinical phenotypes of CVID and, above all, with development of autoimmune disorders.
Oil-producing enterprise
Authors: Nikonoshina N. A. , Dolgikh O. V. , Zaitseva N. V.
Published: August 2022

Arterial hypertension is an urgent health problem worldwide causing an increase in temporary and permanent disability, invalidity and mortality due to cardiovascular diseases. Researchers recognize the multifactorial nature of arterial hypertension, but environmental factors are of particular potential importance. The working conditions at oil production enterprises are characterized by a more pronounced influence of these factors which may predispose for early development of disadaptation disorders, functional changes in immune and humoral regulation, and, finally, for increased risk of cardiovascular diseases in people engaged in oil production. The aim of the present work was to study the features of immunity and humoral risk factors of arterial hypertension in hypertensive employees at an oil-producing enterprise. To this purpose, a comparative analysis of lymphocyte subpopulations (CD3+CD4+, CD3+CD25+), markers of apoptosis (CD3+CD95+, TNFR, p53, Bax, Annexin V-FITC+7AAD), phagocytic activity of leukocytes (absolute phagocytosis index), and the levels of vascular humoral factors (nitric oxide and homocysteine) was performed in employees of an oil production enterprise exposed to adverse production factors. The observational group consisted of employees with established episodes of increased blood pressure. A comparison group consisted of individuals without clinical manifestations of cardiovascular disease. As a result of the clinical and laboratory examination of employees at the oil-producing enterprise with arterial hypertension, some functional changes in immune regulation were revealed. This group was characterized by a significantly (p 0.05) decreased CD3+CD4+, and CD3+CD25+ lymphocyte contents, along with increased levels of regulatory CD127 lymphocytes against the comparison group (p 0.05). The workers at an oil production enterprise with arterial hypertension are characterized by decreased (p 0.05) phagocytic activity of peripheral blood leukocytes using the criteria of absolute phagocytosis. We found some signs of inhibited lymphocyte apoptosis (p 0.05), i.e., a decrease in CD95+, TNFR, and p53 over the background values, as well as increased Bax levels over the comparison group (p 0.05). However, the content of TNFR and p53 significantly (p 0.05) exceeded the reference level, regardless of previous arterial hypertension episodes. Development of the high blood pressure episodes among the employees at oi-producing plant showed a significant association (p 0.05) with elevated levels of homocysteine and nitric oxide concentrations which are known to induce endothelial dysfunction, atherogenesis and, hence, a persistent increase in blood pressure.
Formation of professional skills of future physicians in the process of professional training
Authors: Tsekhmister Yaroslav , Viznіuk Inessa , Humeniuk Vasyl , Dolynnyi Serhii , Polishchuk Anna
Published: August 2022

In the article are grounded and experimentally tested organizational-pedagogical conditions of the formation process of professionalism of future medics. The aim is to show the ways of educational environment modernization by adapting them to modern requirements for professional activity. The methods included an exeperiment –the updating of preparation of the future medical workers by the introduction of innovative educational technologies and interactive methods of training. The results showed an improvement of pedagogical skill of teachers of medical institutions using scientific and methodical work; activation of formation of practical abilities and skills of medical workers through simulation modeling in quasi-professional activity.
Soft Skills formation in professional-oriented foreign language education at higher education institutions
Authors: Hladkoskok Lesia , Buhinska Tetiana , Botvinko-Botiuk Olena , Tytun Oksana , Demianenko Olena
Published: August 2022

The article aims to analyze the constituent characteristics of soft skills and evaluate students' existing skills and their readiness to receive professionally-oriented foreign language training. General scientific methods of cognition are used for the study, including analysis of foreign investigations, periodicals, and surveys conducted by experts and scientists. During the study, the requirements of employers to the personnel for the qualities of soft skills in students are determined. The results show that in foreign language teaching, insufficient attention is paid to the education of these qualities. The study results are of great importance for the higher education teachers forming methodological developments in fostering these soft skills among students.
Esperança e caridade: a proposta evangelizadora de Vasco de Quiroga para os indios da Nova Espanha
Authors: Witeze Geraldo
Published: August 2022

Este artigo apresenta a proposta evangelizadora de Vasco de Quiroga para os índios da Nova Espanha. Trata-se de uma análise a partir de suas obras que abordaram a questão, destacando o contexto de produção, tanto na Europa quanto na América, bem como as influências literárias em sua composição. Ademais, há uma breve discussão sobre o conceito de evangelização que sublinha a importância de compreendê-lo em termos históricos para alcançar um bom entendimento sobre as tentativas de cristianização dos índios no início do período colonial.Palavas-chave: Evangelização; Nova Espanha; Colonização; Vasco de Quiroga.
A construção a partir do outro: a formação da ideia de fronteira no Paraguai colonial baseado na ideia do estrangeiro, século XVII
Authors: Aguiar Ribeiro Fernando Victor
Published: August 2022

Pretendemos contribuir com o debate acerca dos processos de formação de fronteiras na América durante o período colonial. Partindo da premissa de que no século XVI e XVII as fronteiras foram construídas pelos agentes locais, esboçamos um estudo sobre a identidade do estrangeiro no Paraguai de meados do século XVII. Isso porque a delimitação de uma localidade passa pela identidade e pela exclusão dos demais indivíduos. Assim, por meio do estudo de dois casos, o processo de expulsão de um carpinteiro francês de Assunção e da Junta de Guerra de 1676, estabelecemos como se gestou no Paraguai a formação da ideia de alteridade e, portanto, de uma fronteira. Tal delimitação, que assume características de plasticidade e fluidez, é gestada pelos agentes locais conforme suas necessidades e demandas.Palavras-chave: fronteira, estrangeiro, Paraguai
Evidências de circulação e apropriação de saberes farmacológicos e médico-cirúrgicos em um manuscrito anônimo (América Platina, século XVIII)
Authors: Deckmann Fleck Eliane Cristina
Published: August 2022

Neste artigo, apresentamos a análise dos capítulos que compõem o Libro de cirugía, de 1725, um manuscrito ainda inédito e anônimo de medicina e farmácia, que se encontra na Biblioteca do convento da ordem franciscana de Catamarca, Argentina, apontando também para as evidências da apropriação de autores clássicos e contemporâneos ao autor-compilador. Sua transcrição e análise contribuem significativamente para a reconstituição da cultura científica vigente na América platina do Setecentos, principalmente, no que concerne aos saberes e às práticas medicinais que circulavam na região e eram empregados nas reduções jesuíticas da Província Jesuítica do Paraguai.Palavras-chave: Libro de Cirurgía, reduções jesuíticas, Província Jesuítica do Paraguai
La encomienda paraguaya: pueblos de indios en el siglo XVII. Población, familia y trabajo
Authors: Salinas Maria Laura
Published: August 2022

En este artículo nos ocuparemos de abordar aspectos referidos a la población indígena sometida a la encomienda en el período colonial, centrándonos en el siglo XVII en la región que denominamos Nordeste de la gobernación del Río de la Plata y Paraguay. Intentaremos reflexionar sobre las características de la familia indígena en el marco de los pueblos de indios, la relación entre la dinámica demográfica y la aplicación de las encomiendas como así también las posibilidades y las limitaciones de trabajar con las Visitas de indios como fuentes para abordar estas temáticas. Trabajaremos específicamente con una Visita realizada a mediados el siglo XVII por el oidor de la Audiencia de la Plata: Andrés Garabito de León. Encomienda, tributo y formas laborales son algunos de los conceptos que guiarán nuestro análisis en este contexto. Con fuentes de diversos repositorios (Archivo Nacional de Asunción, Archivo General de la Nación – Buenos Aires- entre otros) se pretende ofrecer un estado de la cuestión sobre fuentes y estudios, además de presentar la situación de esta población en el período señalado, temática que invita siempre a reflexionar sobre la formación de la identidad en Paraguay en relación con el nordeste de la actual argentina.Palabras claves: Paraguay- Río de la Plata. Indígenas. Siglos XVII.XVIII
PRAVNI I INSTITUCIONALNI OKVIR JAVNO-PRIVATNOG PARTNERSTVA U REPUBLICI SRBIJI
Authors:   University of Kragujevac, Faculty of Law, Jovanović Zoran
Published: August 2022

As a result of an increasing demand for building new public infrastructures, investing into goods of general interests and more efficient offering of public services, a need has arisen for establishing a suitable legal and institutional framework for attracting private investments into Republic of Serbia. Therefore, new Law on public-private partnership and concessions was adopted in 2011 which introduced the term “public-private partnership” into the legal system of the Republic of Serbia allowing the Government, as well as the provincial government and local self- government units to pass decisions on initiating procedures for the realization of public-private partnerships for the purpose of financing, building, reconstructing, maintaining and managing of infrastructural and other objects of public importance, as well as offering public services, which can be made on contractual or institutional basis. The public-private partnership projects should be economically efficient and socially responsible. The value received from the invested funds should be larger than the one obtained from traditional investment models (through the state budget).
POVREDA FUNKCIJE UPUĆIVANjA NA POREKLO I REKLAMNE FUNKCIJE UPOTREBOM ŽIGA U USLUGAMA KEYWORD-ADVERTISING-A
Authors:   University of Kragujevac, Faculty of Law, Vlašković Božin
Published: August 2022

An infringement of the referral to origin function does not exist when a commercial advertisement appears in an appropriately designated ad block, which is clearly separated from the list of results. In addition, the condition is that the ad unit does not include a trademark, neither refers to the trademark holder and products or services marked with the trademark. In the case of a list of results, an infringement of a referral to origin function exists if the average Internet user is not able to recognize whether the ads originate from the trademark holder, companies economically related to him, or from a third party. An infringement of the advertising function in the case of known trademarks is solved by applying the principles contained in the "Interflora" judgment of the European Court.
SASTAV I NADLEŽNOSTI ETIČKOG ODBORA SRBIJE
Authors:   University of Kragujevac, Faculty of Law, Planojević Nina
Published: August 2022

The topic of this paper is the position and role of one kind of ethics boards in the national law – Ethics Committee of Serbia. The first part of the paper is dedicated to the analysis of the concept, scope, origin and types of ethics boards in Serbia. The second part deals with the issues of the appointment of the members of the Ethics Committee of Serbia and their mandates. In the third section, the author reviews the question of its jurisdiction dividing it into a paralel and exclusive jurisdiction. In the concluding part of the paper the author sums up the results achieved researching this topic and points to some deficiencies in the laws that regulate this matter which should be eliminated in future.
POJEDINAČNO IZUZEĆE UGOVORA O TRANSFERU TEHNOLOGIJE OD KARTELNE ZABRANE U PRAVU KONKURENCIJE EVROPSKE UNIJE
Authors:   University of Kragujevac, Faculty of Law, Šokinjov Stefan
Published: August 2022

The question of individual exemption of technology transfer agreements is propounded in two main cases. The first is when market shares of contractual parties exceed prescribed thresholds for block exemption. The second is when technology transfer agreement involves more than two parties. In these cases the technology transfer agreement can not be exempted on the basis of block exemption rules, but it does not automatically mean that such agreement is prohibited and void. If such technology transfer agreement does not restrain competition or does but general conditions for exemption of restrictive agreements are fulfilled it is considered valid and enforceable.
Gerakan Komunitas Pencinta Alam Bujang Squad Dalam Pelestarian Lingkungan Di Desa Terak
Authors: Pratama M Ade , Zulkarnain Iskandar , Herdiyanti Herdiyanti
Published: August 2022

Lingkungan penting untuk dijaga demi menjamin keberlangsungan makhluk hidup. Gerakan sosial lingkungan menjadi cara penjagaan lingkungan yang mulai marak dilakukan oleh masyarakat yang berkaitan erat dengan komunitas Pencinta alam. Penelitian ini bertujuan untuk menganalisis gerakan dari Komunitas Pencinta Alam Bujang Squad dalam pelestarian lingkungan di Desa Terak, Kecamatan Simpang Katis, Kabupaten Bangka Tengah. Penelitian ini menggunakan metode penelitian kualitatif deskriptif dengan pengumpulan data melalui observasi, wawancara, dan studi pustaka dengan narasumber dari Komunitas Pencinta Alam Bujang Squad, masyarakat serta pemerintah di Desa Terak. Hasil dari penelitian ini menunjukkan bahwa Komunitas Pencinta Alam Bujang Squad terbentuk pada 23 Juli 2017 kemudian dilegalkan pada 2018 dengan diketuai oleh Dondon. Komunitas Pencinta Alam Bujang Squad melakukan kegiatan pelestarian lingkungan yang meliputi pengelolaan terpadu yang mencakup pembibitan, penanaman, pemeliharaan, dan pemanfaatan lahan yang kadangkala melibatkan masyarakat setempat. Selama melakukan kegiatan pelestarian lingkungan di Air Terjun Bukit Mangkol, Komunitas Pencinta Alam Bujang Squad telah menjalin kerja sama dengan beberapa pihak, antara lain Yayasan Gunung Mangkol Lestari (GML); Dinas Lingkungan Hidup (DLH) Kabupaten Bangka Tengah; Dinas Kebudayaan, Pariwisata, Pemuda, dan Olahraga (DISBUDPARPORA) Kabupaten Bangka Tengah; PT PLN (Persero); PT Timah Tbk; Balai Pengelolaan Daerah Aliran Sungai dan Hutan Lindung (BPDASHL) Baturusa Cerucuk; dan, Pusat Penyelamatan Satwa (PPS) ALOBI Foundation.
Perancangan Ulang Identitas Visual UMKM Nagari Kopi Mojokerto Untuk Meningkatkan Brand Awareness
Authors: Nugraeni Elsa Graciana
Published: August 2022

Banyak pelaku bisnis seringkali mengabaikan pentingnya identitas visual merek pada pengembangan bisnisnya. Padahal identitas visual sangat berpengaruh pada keputusan pembelian. Seperti contoh kasus UMKM Nagari Kopi. Nagari Kopi merupakan salah satu UMKM di Kota Mojokerto, Jawa Timur yang menawarkan produk beberapa jenis biji kopi lokal. UMKM ini telah berdiri sejak tahun 2015 namun ternyata belum dikenal banyak masyarakat lokal. Hal ini memengaruhi penjualan produk dan munculnya kedai kopi lokal baru yang lebih terkenal dibanding Nagari Kopi. Oleh karena itu penelitian ini bertujuan untuk merancang identitas visual yang lebih sesuai. Metode penelitian yang digunakan yaitu metode kualitatif dengan teknik pengumpulan data wawancara, observasi dan studi pustaka. Sedangkan teknik analisis data menggunakan analisis SWOT untuk mengetahui faktor internal dan eksternal brand tersebut. Melalui pembahasan dan analisis yang telah dilakukan, didapat hasil bahwa UMKM Nagari Kopi punya potensi untuk berkembang. Cara paling potensi untuk memperbaiki weakness yang ada yaitu dengan membangun identitas visualnya. Maka dari itu dilakukan perancangan identitas visual UMKM Nagari Kopi agar tercipta kebaruan identitas visual yang lebih sesuai dan menarik, serta digunakan secara konsisten. Perancangan ini diharapkan mampu menaikkan brand awareness dan penjualan produk biji kopi lokal UMKM Nagari Kopi.
Hubungan Kesiapan E-Learning Terhadap Hasil Belajar Mata Pelajaran IPA Dan Matematika
Authors: Chriswibowo Dionisius Regenza Kevindanu
Published: August 2022

Kesiapan E-learning merupakan situasi atau kondisi yang menunjukkan kesiapan secara fisik maupun mental dalam memberikan respon dalam proses pembelajaran dengan menggunakan jaringan internet. Penelitian ini bertujuan untuk melihat hubungan antara kesiapan e-learning siswa terhadap hasil belajar pada mata pelajaran IPA dan Matematika kelas III A SD Strada Budi Luhur I. Penelitian ini menggunakan penelitian deskriptif korelasional, di mana pengambilan subjek diambil kelas III A berjumlah 42 siswa. Instrumen pengambilan data yang digunakan yaitu angket kesiapan e-learning dan tes hasil belajar pada mata pelajaran IPA dan Matematika. Hasil penelitian dianalisis dengan menggunakan uji normalitas, untuk melakukan uji korelasi product moment. (1) Hasil analisis menunjukkan terdapat hubungan positif kesiapan e-learing dengan hasil belajar IPA sebesar 0,425 dan (2) kesiapan e-learning dengan hasil belajar matematika sebesar 0,118. Kesimpulan penelitian ini yaitu adanya hubungan yang positif kesiapan e-learning siswa dengan hasil belajar pada mata pelajaran IPA di SD Strada Budi Luhur I. Saran dari penelitian ini yaitu guru membimbing siswa supaya pembelajaran menggunakan e-learningdapat ditingkatkan
Upaya Meningkatkan Kemampuan Koneksi Matematis Siswa Dengan Model PBL (Problem Based Learnin) Pada Materi Integral Kelas XI IPS 1
Authors: Aprilyani Nuri
Published: August 2022

Penelitian tindakan kelas ini bertujuan untuk meningkatkan kemampuan koneksi matematis pada materi integral siswa kelas XI IPS 1 SMA Negeri 3 Tangerang. Pembelajaran tindakan kelas didasarkan pada rendahnya rata-rata nilai ulangan harian sebelum tindakan. Hipotesis penelitian tindakan yang diajukan dalam penelitian ini adalah peningkatan kemampuan koneksi matematis siswa dengan model PBL pada kelas XI IPS 1 semester genap SMA Negeri 3 Tangerang". Subjek penelitian berjumlah 37 siswa. Berdasarkan penelitian yang telah dilakukan dapat disimpulkan hal-hal sebagai berikut: pada kemampuan Koneksi Matematis siswa sebelum tindakan, nilai rata-rata kelas 68,135 dengan persentase ketercapaian KKM 48,65% dan pada kemampuan koneksi matematika siswa siklus I nilai rata-rata naik menjadi 73,432 dengan persentase ketercapaian KKM 64,86% sedangkan pada siklus II nilai rata-rata meningkat menjadi 78,270 dengan pencapaian KKM 83,78%.
Pembentukan Karakter Mahasiswa Melalui Pendidikan Kewarganegaraan
Authors: Al Fikri Muhammad Arif
Published: August 2022

Tujuan dari penulisan artikel ini adalah untuk mengungkap pembentukan karakter mahasiswa melalui Mata Kuliah Pendidikan Kewarganegaraan (PKn).  Permasalahan karakter pada generasi muda yang banyak ditemukan akhir-akhir ini. Penuruanan karakter tersebut umumnya ditunjukkan gambaran ke arah yang lebih kelam, antara lain aksi anarki, aksi curang, mengabaikan aturan yang berlaku, kematangan seksual yang sangat dini, menurunnya tanggung jawab warganegara dan masih banyak sebagainya. Penulisan artikel ini menggunakan metode studi kepustakaan, yaitu dengan mengumpulkan literatur-literatur dari berbagai sumber yang berkaitan dengan “Pembentukan Karakter Mahasiswa Melalui Pendidikan Kewarganegaraan”. Artikel ini menghasilkan bahwa pendidikan karakter adalah usaha menanamkan kebiasaan-kebiasaan yang baik (habituation) sehingga peserta didik mampu bersikap dan bertindak bersadarkan nilai-nilai yang telah menjadi kepribadiannya. Pembangunan karakter dilakukan pendekatan sistematik integrative melibatkan satuan pendidikan, pemerintah, sipil, anggota legsilatif, dan media masa. Pendidikan Kewarganegaraan di perguruan tinggi sangat berguna umtuk membentuk mahasiswa berkarakter nilai luhur ideologi Negara Indonesia. Memperkokoh dan mengembangkan karakter mahasiswa dari pendidikan sebelumnya. Pendidikan Kewarganegaraan merupakan salah satu formulasi yang tepat untuk membangun karakter generasi muda.