bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultivating learning quality with E-training, principal leadership, teachers’ competences and mujahadah
Authors: Prilianti Ratna , Sutarto Joko , Yanto Heri , Prihatin Titi
Published: November 2022

This study aimed to analyse the effects of e-training, madrasah principals’ leadership and teachers’ pedagogical competence on learning quality through teachers’ mujahadah using descriptive and path analysis with the help of Amos 24. The data were collected from 382 madrasah teachers who have participated in e-training in 2021 using a 4-point Likert scale questionnaire. The results showed that (1) teachers’ mujahadah affected learning quality; (2) teachers’ pedagogical competence affected teachers’ mujahadah; (3) e-training affected learning quality (4) madrasah principals’ leadership affected teachers’ mujahadah; (5) madrasah principals’ leadership affected e-training; (6) madrasah principals’ leadership affected teachers’ pedagogical competence; (7) e-training affected teachers’ mujahadah; and (8) e-training affected teachers’ pedagogical competence. In conclusion, improving the learning quality of madrasahs in Central Java is determined by teachers’ mujahadah, e-training, madrasah principals’ leadership and teachers’ pedagogical competence. Stakeholders are suggested to consecutively provide more courses and trainings to keep teachers voguish of any adjustments, innovations and modifications in education.
Keywords: Learning quality, e-training, mujahadah, pedagogical competence, principal leadership
Satisfaction of female students at the college of education with distance field training in light of some demographic variables
Authors: Abdelgwad Mervat Azmi Zaki
Published: November 2022

The purpose of this research is to identify female students’ satisfaction level with distance field training at the College of Education in light of some of the demographic variables. A questionnaire on students' satisfaction with distance field training was applied to a sample of 102 female students (mean age = 20.029, SD = 0.813). Data were analysed by mean, standard deviations, frequencies and percentages; and t-test was used for differences between independent samples. The research findings revealed that the degree of satisfaction of the female students with distance field training was high. Besides, there were also no differences in their satisfaction level due to the academic specialisation (special education–kindergarten) and the academic average (high, medium and low), while there were significant differences due to the academic level variables (seventh–eighth), in favour of the eighth level. The research results were discussed in light of the previous related literature and further research suggestions were provided to researchers and stakeholders.
Keywords: Demographic variables, distance field training, College of Education, satisfaction.
Enhancing students’ literacy skills through social constructivism-based literacy learning environment model
Authors: Hilmawan Hilman , Musthafa Bachrudin , Agustin Mubiar
Published: November 2022

The aim of this study was to enhance students’ literacy skills through a social constructivism-based literacy learning environment model. The research method used was a quasi-experimental design with a non-equivalent pre-test and post-test control group design. Participants in this study were 74 third-year students of one of the public elementary schools. The instruments were the reading skill test and rubric instruments to assess narrative essay writing skills. Data were analysed through the average score and hypothesis test. The average scores of reading and writing in the experimental class were higher than the control class. Then, there is a significant influence of the social constructivism-based literacy learning environment model and regular learning on students’ literacy skills. Moreover, there is a significant difference between the influence of learning in the experimental and control classes. It can be concluded that a social constructivism-based literacy learning environment model can enhance students’ literacy skills.        
 
Keywords: Literacy learning environment model; literacy skills; social constructivism
Development of the project activities of future primary school teachers based on a collaborative environment
Authors: Seidualiyeva Arailym , Stambekova Assel , Meterbayeva Kulbarshyn , Аrzanbayeva Bakhytzhamal , Aitzhanova Elmira , Sekenova Aigerim
Published: November 2022

The aim of this study is to determine the views of future primary school teachers on the development of project activities based on a collaborative environment. Permanent teaching is provided by providing diversity in learning with new generation learning techniques. For this purpose, the project activities listed in the education faculties of the universities were analysed. Primary school teacher candidates' opinions on whether education is provided in a cooperative learning environment in project activities are very important. Depending on the results of this research, it will be clear whether the prospective classroom teachers will use these techniques in their future professional lives. For this purpose, a qualitative research method was used with the participation of 72 university students in the spring term of 2021–2022 in order to determine the opinions of the students of the classroom teaching department studying at the university about the collaborative environment. Project-based teaching and two universities with education faculties were included in the research. The research study group consists of senior students studying at the education faculty of the university. As a result of the survey, the opinions of future classroom teachers about the probe activities and the collaborative environment were taken. Semi-structured interview questions prepared by the researchers were asked of the students. It was revealed that, in the last year, teacher candidates studying in the department of primary school teaching were effective in project-based learning and supported the collaborative approach. In the same way, it was suggested that the project activities of the teacher candidates should be increased.

 

Keywords: Teacher training, classroom teaching, project-based teaching, collaboration, education
Forming the development of a value relationship to a healthy lifestyle among future primary school teachers based on healthcare technology
Authors: Akzaru Espanova , Uaisova Gulnar , Zhakenkyzy Kurman Nesibeli , Kalimukhasheva Bagit , Koshkin Erkebulan , Kurmanbekova Aigul
Published: November 2022

The aim of this study is to obtain the opinions of prospective teachers in order to create the development of the value relationship between the healthy lifestyle and the value of future primary school teachers based on health technology. This research was created in accordance with the qualitative research method. The study group of the research consists of 25 teacher candidates studying in primary school teaching departments in various universities in Kazakhstan. The data collection tool for the research is the semi-structured interview form developed by the researchers. As a result of the research, future primary school teachers stated that they had a healthy lifestyle, balanced and healthy nutrition, regular exercise, avoided harmful habits like alcohol and smoking, avoided stress, protected mental and emotional health and acquired regular sleep habits. They stated that technological devices are used in the field of health, health technology shortens the healing process, facilitates health practices, saves time, requires professional application and use and increases awareness. Moreover, the majority of future primary school teachers stated that they strongly support the development of the value relationship with a healthy lifestyle based on health technology.

Keywords: Healthy life, health technology, primary school teachers of the future;
Robotic-based takraw blocker technique skill tool: Development and students’ perceptions
Authors: Arwandi John , Bais Syahril , Soniawan Vega , Sari Suci Nanda , Padli Padli , Ridwan M.
Published: November 2022

The purpose of this research is to develop a robotic-based block takraw technique skill tool. This research method is a development that uses the ADDIE model. The sample in this study comprised 25 athletes. The research instrument used was an expert validation questionnaire and a student perception questionnaire. The data analysis technique used is descriptive statistics for quantitative data and Miles and Huberman’s technique for qualitative data. The results of expert validation of exercise measurement and evaluation tests, takraw expert validation and media expert validation showed very good results where the product developed was feasible to use. The results of students’ perceptions of the robotic-based block takraw technique skills showed very good results as well. Therefore, this robotic-based block takraw technique skill tool is very good as a supporting tool in training to improve the smash ability of takraw athletes.

Keywords: Blocker Technique; Development; Perception; Robotics; Skill tool; Takraw
Evaluation of dietary α-lipoic acid supplementation on the growth performance and physiological status of striped catfish Pangasianodon hypophthalmus
Authors: Ratnawati Rifai  , Dedi Jusadi  , Muhammad Agus Suprayudi  , Alimuddin  , Sri Nuryati
Published: November 2022

This study aimed to evaluate the dietary supplementation of α-lipoic acid (ALA) on the growth performance, antioxidative capacity, and protein-sparring effect of striped catfish (Pangasianodon hypophthalmus) fingerling. The striped catfish (individual weight of 1.4 ± 0.0 g) were stocked in 25 cages at 2x1x1.5 m size in a 200-m pond at 50 fish. Fish were fed formulated diets with ALA supplementation, namely: diet A (27% protein: 390 kcal), diet B (27% protein: 390 kcal +ALA 8 g/kg), diet C (27% protein: 400 kcal), diet D (27% protein: 400 kcal +ALA 8 g/kg), and diet E (30% protein: 390 kcal). Feeding was performed until apparent satiation for 60 days. The ALA supplementation significantly produced higher final individual weight, specific growth rate, and protein efficiency ratio, followed by a lower feed conversion ratio on the 27:390+ALA diet treatment (P<0.05) than other diet treatments. The highest liver performance based on superoxide dismutase enzyme activity and glycogen contents was obtained from the 27:390+ALA diet treatment. The malondialdehyde, triglycerides, and lipid accumulation in the liver on the 27:390+ALA diet treatment were lower than other diet treatments (P<0.05). Therefore, the best growth performance and physiological status in striped catfish was obtained from 27:390+ALA diet treatment.
Pouvoir et Action Publique : Cristallisation des Politiques Publiques et Prélude à la Solution des Problèmes Publics
Authors: Ruedarodríguez Dhamaris Maidely Martínez , Mballa Louis Valentin , Rivera Ma. Patricia Torres , Campos Miguel Ángel Vega
Published: November 2022

L'objectif de cet article est d´analyser les aléas des variables de pouvoir et d'action publique dans la recherche de solutions aux problèmes publics à travers l'idéation, la formulation et la mise en œuvre des politiques publiques. Utilisant une méthode d'analyse qualitative, l'article soutient que le pouvoir et l'action publique cristallisent la nature des solutions aux problèmes publics. Cela indique que les politiques publiques constituent aujourd'hui le cordon ombilical entre la société et l’État à travers l'exercice du pouvoir par le gouvernement. En d'autres termes, les politiques publiques ne sont pas des outils ambigus, mais plutôt la mise en œuvre de certaines orientations et styles de gouvernement, ce qui est d'une importance transcendantale car, dans leur dimension fondamentalement empirique, les politiques publiques ont le pouvoir d’inverser, de renforcer ou d'inhiber la capacité d'autres mécanismes qui conduisent au bien-être individuel et collectif. Avec une méthode d'analyse qualitative, nous concluons que les politiques publiques nécessitent d’une vision holistique, plus alignée sur les compétences multidimensionnelles, individuelles et collectives, tant du gouvernement que des citoyens.
Longitudinal analyses of composite resin restoration on erosive lesions
Authors: Reis Renato Gonçalves dos , Tedesco Antônio Cláudio , Curylofo-Zotti Fabiana Almeida , Cortez Thiago Vinicius , Borges Hiago Salge , Souza-Gabriel Aline Evangelista , Corona Silmara Aparecida Milori
Published: November 2022

Aim: To evaluate the influence of the biomodification of erosive lesions with a chitosan nanoformulation containing green tea (NanoCsQ) on the clinical performance of a composite resin. Methods: The study was performed in a split-mouth, randomized and double-blinded model with 20 patients with 40 erosive lesions. The patient’s teeth were randomized into two groups (n=20) according to the surface treatment: 1) Without biomodification (control), and 2) Biomodification with NanoCsQ solution (experimental). The lesions were restored with adhesive (Tetric N-bond, Ivoclar) and composite resin (IPS Empress Direct, Ivoclar). The restorations were polished and 7 days (baseline), 6 months, and 12 months later were evaluated according to the United States Public Health Service (USPHS) modified criteria, using clinical exam and photographics. Data were analyzed by Friedman’s and Wilcoxon signed-rank tests. Results: No significant differences were found between the control and experimental groups (p=0.423), and also among the follow-up periods (baseline, six months, and 12 months) (p=0.50). Regarding the retention criteria, 90% of the restoration had an alpha score in the control group. Only 10% of the restorations without biomodification (control) had a score charlie at the 12-month follow-up. None of the patients reported post-operatory sensitivity. Conclusion: The NanoCsQ solution did not negatively affect the performance of the composite resin restorations after 12 months.
ONION EXTRACT (ALLIUM CEPA) MEDERMA® UNTUK BEKAS LUKA OPERASI PADA WAJAH
Authors: Amandita Tiara , Saputro Iswinarno
Published: November 2022

Penanganan pasien dengan trauma wajah terus mengalami perkembangan dalam era penatalaksanaan terkini.1 Meskipun proses penyembuhan luka berlangsung secara normal, adanya bekas luka pada proses penyembuhan luka merupakan suatu permasalahan medis yang dapat mengakibatkan hilangnya fungsi, limitasi pertumbuhan jaringan, permasalahan estetik dan permasalahan pada psikologis.3 Pada laporan kasus ini, Onion extract (Allium cepa) Mederma® diaplikasikan sebagai penanganan luka bekas operasi pada area wajah. Observasi dan evaluasi yang dilakukan pada pasien menunjukkan hasil yang baik pada bekas luka, sehingga penggunaan Onion extract (Allium cepa) Mederma® pada bekas luka operasi pada wajah dapat menjadi pilihan dalam terapi penanganan luka di daerah wajah.
PASIEN SINDROMA APERT YANG DILAKUKAN OPERASI FRONTO ORBITAL ADVANCEMENT SETELAH OCCIPITAL EXPANSION
Authors: Putria Almahitta Cintami Putria , Prasetyo Arif Tri Prasetyo , Amelia Febrina
Published: November 2022

Sindroma Apert atau acrocephalosyndactyly tipe I merupakan kelainan kongenital yang ditandai dengan adanya kraniosinositosis, exorbitism, midface hypoplasia dan sindaktili simetris pada tangan dan kaki, hal ini disebabkan oleh mutasi genetik dari FGFR-2, S252W dan P253R. Tatalaksana kraniosinostosis bertujuan untuk memperbaiki fungsi serta estetik dari pasien dengan tindakan awal adalah dilakukan dekompresi kalvaria dengan intervensi pembedahan yaitu occipital expansion pada usia 6 bulan dan dilanjutkan dengan fronto-orbital-advancement (FOA). Pada kasus ini dilakukan tatalaksana occipital expansion dan dilanjutkan dengan FOA  dengan hasil yang cukup memuaskan.
Relationship of Sleep Quality with Quality of Life in Chronic Kidney Failure Patients Undergoing Hemodialization During the Covid-19 Pandemic
Authors: Ulinnuha Lu'lu' Luthfiatun , Trishinta Sirli Mardianna , Rosdiana Yanti
Published: November 2022

Introduction :
Poor sleep quality is often experienced by patients with chronic kidney failure (CKD) undergoing hemodialysis (HD) therapy, this can affect their quality of life. The purpose of this study was to determine the relationship between sleep quality and quality of life in chronic kidney failure patients undergoing hemodialysis during the COVID-19 pandemic at Panti Waluya Sawahan Hospital, Malang City.
Method :
This research design is cross sectional. The population in this study were patients with chronic kidney failure who underwent hemodialysis, namely 126 respondents at Panti Waluya Sawahan Hospital, Malang City during January, obtained a sample of 36 respondents using purposive sampling technique. Data collection techniques used the Pittsburgh Sleep Quality Index (PSQI) questionnaire and The World Health Organization Quality of Life (WHOQOL – BREF) questionnaire. Data analysis used Chi Square test (p value < 0.05).
Result :
The results of the study, most of the respondents had poor sleep quality and most of the respondents had poor quality of life. The results of the chi square test showed that there was a relationship between sleep quality and quality of life in chronic kidney failure patients undergoing hemodialysis during the COVID-19 pandemic at Panti Waluya Sawahan Hospital, Malang City with a p-value of 0.000.
Conclusions :
The conclusion of this study is that there is a relationship between sleep quality and quality of life in chronic kidney failure patients undergoing hemodialysis during the COVID-19 pandemic at Panti Waluya Sawahan Hospital, Malang City
Problemas de saúde mental na população rural brasileira: prevalência, fatores de risco e cuidados
Authors: Sombra Neto Luis Lopes , Forte Morgana Pordeus do Nascimento , Pessoa Vanira Matos , Campos Eugênio de Moura
Published: November 2022

Objetivo: Descrever as evidências científicas recentes sobre saúde mental nas populações rurais brasileiras. Método: Trata-se de um artigo de revisão com busca realizada nas bases de dados Scielo, Lilacs e Medline, utilizando-se os descritores “Saúde mental”, “Rural” e “Brasil” e seus correspondentes em inglês, e em documentos publicados pelo Ministério da Saúde, pelo IBGE e pela Fiocruz. Resultados: A porcentagem de pessoas que vivem em territórios rurais brasileiros com diagnóstico de depressão é de 7,6%, predominantemente do gênero feminino. Pesquisas nacionais detectaram 24,1% de indivíduos com transtornos mentais comuns e 8,4% de pessoas com transtornos relacionados ao uso de álcool. Entre os fatores associados aos problemas de saúde mental, sobressaem-se baixa escolaridade, baixa renda, uso de medicamento para dormir, tabagismo e problema mental prévio. Destaca-se o papel da Atenção Primária à Saúde (APS) como responsável por inserir as famílias rurais nos cuidados, entretanto, observa-se a falta de ações específicas voltadas para essa problemática e a carência de capacitação profissional em saúde mental. Conclusão: Todos esses dados demonstram a importância do estudo da saúde mental nas populações rurais e de se buscar a prevenção de fatores de risco, fortalecer o papel da APS nos cuidados e proporcionar melhor qualidade de vida para indivíduos com sofrimento mental.
SIMULASI DAN PERANCANGAN BILAH TURBIN ANGIN SAVONIUS HELIKS DENGAN MEMANFAATKAN FENOMENA ANGIN PADA GEDUNG TINGGI
Authors: Muhammad Irfan
Published: November 2022

Bentuk topografi bumi yang tidak rata menyebabkan banyaknya terjadi fenomena yang dapat membelokkan dan mengubah karakter kecepatan angin. Fenomena ini dapat terjadi karena faktor alam dan faktor campur tangan manusia. Hadirnya kompleks gedung tinggi menjadi salah satu penyebab terjadinya fenomena downwash dan venturi effect. Kedua fenomena tersebut terkenal karena menghasilkan hembusan angin yang cukup signifikan untuk mengganggu kenyamanan pejalan kaki. Oleh karena itu, pada penelitian ini penulis akan menghitung perubahan karakter kecepatan angin dengan pengaruh kedua fenomena tersebut sebagai potensi energi penggerak untuk tiga varian turbin angin sumbu vertikal tipe heliks dengan media simulasi Computational Fluid Dynamic (CFD). Proses simulasi terbagi menjadi dua tahap, yang pertama penulis menjalankan simulasi pengaruh fenomena angin terhadap karakter kecepatan angin alami, yang menunjukkan adanya peningkatan kecepatan angin sebesar 40%. Dan yang terakhir yaitu simulasi keluaran daya masing – masing varian turbin angin dengan menggunakan data kecepatan angin pada tahap sebelumnya. Hasilnya menunjukkan bahwa turbin angin sumbu vertikal tipe heliks dengan variasi bilah normal dapat menghasilkan daya optimal sebesar 447,8 watt.
Limiting carbohydrates to trunk and roots improves bud fruitfulness, fruit set and yield in cv. Malbec
Authors: Carrillo Natalia , Piccoli Patricia , Gallusci Philippe , Guardabrazo María Sol , Berli Federico
Published: November 2022

Many commercial vineyards of Malbec, the most cultivated grapevine in Argentina, show unstable yield because of variations in bud fruitfulness and the occurrence of “shatter”, characterised by poor fruit set and fruitlet abscission. Shatter can be due to plant material, growing conditions and meteorological events. Among the parameters that determine fruit set efficiency and vine yield, the availability of carbohydrates (CH) plays an essential role. We previously showed that controlling CH partitioning by removing part of the phloem tissue through an annular incision at the base of the fruit shoots (shoot girdling) reduced shatter in Malbec. The objective of this research was to evaluate the partitioning of CH for the different sink organs of the aerial part of the plant when an interruption of phloem flux from leaves to storage organs is imposed by a girdle. Shoot and trunk girdling trials were conducted during the 2018 and 2019 growing seasons, respectively. At flowering, girdling was performed on different plant lots either at the base of the shoot (Base G), above the distal cluster of the shoot (Top G), to the trunk (Trunk G) or no girdling (Control). Most of the yield components were increased by Base G and Trunk G with no significant impact on vegetative growth or fruit quality. Total shoot biomass was not affected in Base G, while a 39 % reduction was observed in Top G, as compared to Control. The partitioning pattern within the shoot was modified by shoot girdling, and Base G favoured the accumulation of CH towards clusters at the expense of lateral shoots. Shoot girdling increased node diameter, bud fruitfulness and inflorescence dry weight of the shoot. Trunk-girdled vines showed an increase in fruit set and total yield at harvest, with no significant impact on vegetative growth. The restriction of CH flow to the trunk and roots by Base G and Trunk G at flowering increased yield components at harvest without affecting vegetative growth or grape quality. These results reinforce our hypothesis that the root system of the vines under study constitutes a strong sink during the flowering period that competes for CH.
Is it time to reconsider our understanding of lifelong learning in medical training
Authors:   University of Dundee, McMillan James C. D.
Published: November 2022

In this discussion article, based on research conducted as part of a master’s project at the University of Dundee School of Medicine, I argue that professional training programmes may benefit from more scrutiny of the concept of lifelong learning and less reliance on cultural norms and implicit professional narratives.
El papel del color en la ingesta de fragmentos de microplástico por el pez cebra (Danio rerio)
Authors:   Instituto de Medicina y Biología Experimental de Cuyo (IMBECU, CCT-CONICET), Manuel Ríos Juan
Published: November 2022

Se ha reportado la presencia de microplásticos (MP) en el contenido estomacal de peces de agua dulce a nivel global. Sin embargo, los mecanismos subyacentes al consumo de MP por parte de los animales acuáticos aún no están claros. En este estudio se investigó la pregunta fundamental de por qué los peces silvestres de agua dulce ingieren plástico. La ingesta de MP debida a la confusión por parte de los peces con sus presas naturales, tales como el plancton, es una hipótesis que ha cobrado importancia últimamente. Por lo tanto, el color del MP podría influenciar su consumo, especialmente en depredadores visuales. Con el objetivo de evaluar la ingesta de fragmentos de MP según el color (rojo, verde, amarillo, blanco, negro y azul), se llevó a cabo un experimento de opción múltiple en el laboratorio utilizando al pez cebra (Danio rerio) como modelo de estudio. Los resultados indicaron que frente a una oferta de igual proporción de MP de distintos colores, el pez cebra prefirió consumir los fragmentos de color azul, mientras que evitó consumir los verdes y los blancos. Aunque todavía no está claro en qué forma se relaciona la coloración del plástico con la selectividad y consumo en peces de agua dulce, las habilidades visuales de los peces podrían explicar por qué ciertos colores son atractivos para una especie de pez en particular.
The Effect of Wound Treatment Using Honey on Colonization of Staphylococcus Aureus Bacteria in Diabetic Wounds in Patients with Diabetes Mellitus in the Work Area Banjarmasin Health Center
Authors: Ardila Novia , Maharani Rizky , Sabella Amalia , Negara Candra Kusuma
Published: November 2022

Background : Diabetic wounds are very easy to experience complications in the form of infection due to bacterial invasion, and sugar conditions blood which tall encourage the growth of bacteria.Bacteria that can cause infection in diabetic wounds wrong one is staphylococci aureus . Wound diabetes can treated with honey. Honey contains antibacterial , antioxidant and hydrogen peroxide properties that help kill bacteria dangerous. Objective : The purpose of this study was to determine the effect of the wound dressing contains honey against bacterial colonization Staphylococcus aureus on wound diabetic . Methods : The research design used is pre-experimental with o ne-group pre-test and post-test design . Sampling method using consecutive sampling as many as 7 respondents. Results : Analysis data use test dependent t-test and obtained score p value 0.000 ( p value < = 0.05), so could concluded there is influence care wound use honey to colonization bacteria Staphylococcus aureus in wounds diabetic Diabetes Mellitus patients in the region work Public health center Banjarmasin . Conclusion : best Use honey as product care wound because nature the antibacterial which could prevent infection and speed up process healing wound .
Data-Independent Acquisition (DIA) is Superior for High Precisely Phospho-Peptide Quantification in Fungi
Authors: Bersching Katharina , Michna Thomas , Tenzer Stefan , Jacob Stefan
Published: November 2022

The dynamic interplay of signaling networks in most major cellular processes is characterized by the orchestration of reversible protein phosphorylation. Consequently, analytic methods like quantitative phospho-peptidomics has been pushed forward from a highly specialized edge-technique to a powerful and versatile platform for comprehensively analyzing the phosphorylation profile of living organisms. Despite enormous progress in instrumentation and bioinformatics, a major problem remains a high number of missing values caused by the experimental procedure due to either a random phospho-peptide enrichment selectivity or borderline signal intensities, which both cause the exclusion for fragmentation using the commonly applied data dependent acquisition (DDA) mode. Consequently, an incomplete dataset reduces confidence in the subsequent statistical bioinformatic processing. Here, we successfully applied data independent acquisition (DIA) by using the filamentous fungus Magnaporthe oryzae as model organism and could prove that while maintaining data quality (such as phosphosite and peptide sequence confidence), the data completeness increases dramatically. Since the method presented here reduces the LC-MS/MS analysis from 3 h to 1 h and increases the number of phoshosites identified up to 10-fold in contrast to published studies in fungi, we pushed the phospho-proteomic technique beyond its current limits and could provide a sophisticated resource for investigation of signaling processes in filamentous fungi.
Diagnostic Accuracy of Methods for Detection of Antibodies against Type I Interferons in Patients with Endocrine Disorders
Authors: Nuralieva Nurana , Yukina Marina , Sozaeva Leila , Donnikov Maxim , Kovalenko Liudmila , Troshina Ekaterina , Orlova Elizaveta , Gryadunov Dmitry , Savvateeva Elena , Dedov Ivan
Published: November 2022

Autoantibodies against type 1 interferons (IFN-I) are highly specific marker for type 1 autoimmune polyglandular syndrome (APS-1). In this study, a comparison of three different me-thods, namely, multiplex microarray-based, cell-based and enzyme-linked immunosorbent assays for detection of antibodies against omega-interferon and alpha2-interferon was carried out. A total of 206 serum samples from adult patients with APS-1, APS-2, isolated autoimmune endocrine pa-thologies, non-autoimmune endocrine disorders and healthy individuals were analyzed. In the APS-1 patient cohort (n=18), there was good agreement between the results of anti- IFN-I antibody tests performed by three methods, with 100% specificity and sensitivity for microarray-based assay. Although only the cell-based assay can determine the neutralizing activity of autoantibodies, the microarray-based assay can serve as a highly specific and sensitive screening test to identify anti- IFN-I antibody positive patients.
Resistance and Tolerance to Viroid Infection
Authors: Naoi Takashi , Li Shifang , Sano Teruo
Published: November 2022

Viroids are known the smallest plant pathogens, and although their genome sequences do not encode proteins, they can cause disease in economically important crops. In order to control viroid diseases and mitigate their damage, genetic resources used for breeding of the viroid-resistant crop have been searched, but the practical resistant trait has not been found in almost all viroid-crop combinations, as well as the tolerant trait. Due to the difficulty in exploiting naturally occurring resistance or tolerance, various effective strategies have been devised to control viroid diseases using non-transforming or transforming techniques. Meanwhile, extensive findings related to viroid resistance and tolerance may lead to confer resistance or tolerance to viroid infection by combining with the recently emerged new technologies (e.g., spray-induced gene silencing and genome-editing technologies), which are believed to be more environmentally viable and acceptable to the general public than previously reported approaches. In particular, some genome-modified crops produced by the latter technology are already on the market. In this review, we comprehensively summarize the current status about investigation of naturally occurring genetic traits for viroid resistance and tolerance, accumulating knowledge about host factors involved in viroid pathogenicity, and various basic technologies developed to try to possible viroid disease control strategies. Furthermore, we discuss prospects and challenges for the achievement of more effective, practical, and sustainable disease control of viroid.
Pelatihan Pembuatan Soal Berbasis HOTS Bagi Guru Mata Pelajaran Sejarah SMA di Kabupaten Karanganyar
Authors: Kurniawan Dadan Adi , Sutiyah Sutiyah , Djono Djono , Purwanta Hieronymus , Pelu Musa , Isawati Isawati , Herimanto Herimanto , Suryani Nunuk
Published: November 2022

History is a subject that is often considered boring, especially by students at the high school (SMA) level, including high school in Karanganyar Regency, Central Java. Boredom is generally caused by much historical material, tends to be memorized, and the learning process is monotonous in terms of teachers' models, methods, techniques and questions. History questions are considered less varied because they often feature multiple-choice types and standard descriptions. As a result, students need to be more developed in optimizing their potential thinking power. For this reason, the UNS History Education Study Program initiated training in preparing HOTS (Higher Order Thinking Skills) questions as an essential provision for high school history teachers in Karanganyar. The method used is training, mentoring and assignment. Through this training, it was concluded that: First, history teachers must understand the meaning, purpose and importance of using HOTS-based questions in 21st-century history learning. Second, history teachers must understand various types of history questions such as essays, multiple choice, true-false, completion, short answer, and assignment. Third, history teachers must practice mastering the skills of compiling HOTS-based varied history questions. Fourth, implementing the HOTS-based varied history questions in daily high school history learning so that it becomes a habit.
Elena Poniatowska: El testimonio como impureza de la memoria
Authors: Cavallin Calanche Claudia
Published: November 2022

La imagen del subalterno en las fotografías se asume como complemento de las carencias en el testimonio social de los oprimidos, especialmente en la obra de Elena Poniatowska. La noche de Tlatelolco (1971) forma parte de una realidad censurada, donde las fotografías detallan el dolor de los cuerpos y la ausencia de lo que nunca se pudo incluir en ellas: las palabras, los silencios, los colores, y otras formas de expresar ciertas carencias que Barthes ha categorizado a través de las palabras móviles.
El drama migratorio en el Mediterráneo
Authors: Abreu Colombri José Antonio
Published: November 2022

Etienne Huver y Jean-Baptiste Renaud. Salir del infierno: Libia y sus campos de refugiados. Berlín, DW Documental, 2021, 43 minutos.
A dos décadas del caso Campo Algodonero
Authors: Camarillo Hinojosa Jesús Antonio
Published: November 2022

En noviembre de 2021 se cumplen dos décadas del hallazgo, en el lugar conocido como "Campo Algodonero", de los cuerpos de las jóvenes asesinadas en Ciudad Juárez. El caso adquirió una trascendencia internacional. El texto alude a la sentencia emitida por la Corte Interamericana de Derechos Humanos, haciendo un breve recuento de su contenido, en un asunto que, por muchas razones, sigue abierto en el imaginario y contexto de la violencia contra la mujer
PROTOTYPE ALAT NOTIFIKASI KETINGGIAN AIR DAN PEMUNGUTAN SAMPAH OTOMATIS ANTISIPASI BANJIR DENGAN SENSOR ULTRASONIK WITH GLOBAL SYSTEM FOR MOBILE COMMUNICATIONS
Authors: Kharisma Hidayah Agung , Apriza Ririn , Toyib Rozali
Published: November 2022

Gubernur Rohidin meminta agar Pemerintah Kota Bengkulu harus memperketat perizinan pembangunan perumahan sehingga masih tersedia ruang terbuka hijau, perbaiki Daerah Aliran Sungai (DAS) dengan ekosistemnya dan rutin pemberisihan sampah-sampai yang menyubat drenase di dalam kota dan pintu-pintu air yang masuk dari aliran sungai yang masuk ke Kota Bengkulu yang menyebabkan banjir karena terjadi hujan di hulunya dan tidak adanya peringatan dini ketika air mencapai kota Bengkulu serta banyaknya sampah-sampah yang menyumbat di pintu-pintu air semakin memperparah kondisi. Prototype alat notifikasi ketinggian air sistem for mobile Communication yang memungkinkan pemberitahuan dini bila di pintu air terjadi kenaikan ketinggian sehingga masyarakat bisa waspada serta dirancang juga alat pemungutan sampah otomatis dengan sensor ultrasonic yang bisa mendeteksi sampah yang mendekati  di pintuh air dengan jarak yang telah ditentukan. Hasil pengujian ada  notifikasi yang telah dilakukan dapat mengirim Sms Secara 0tomatis ke nomor tujuan dan mengeluarkan alarm kemudian mengeluarkan suara speaker sebagai petanda adanya ketinggian air. benda yang dapat dipungut oleh konveyor tersebut yaitu berupa sampah sampah yang ringan yang berda di permukaan air. Sistem informasi robot yang berupa LCD yang akan menampilkan hasil ketinggian air tersebut
Robust and Efficient Identification of Hydraulic Flow Units using Differential Evolution Optimization and Two-Stage Clustering Techniques
Authors: Al-Ismael Menhal A. , Awotunde Abeeb A.
Published: November 2022

One essential process in reservoir characterization is the identification of hydraulic flow units (HFUs). It plays a critical role in determining hydrocarbon reserves and improving reservoir productivity. Flow zone indicator (FZI), determined from core data, is widely used to identify HFUs. One of the challenges in the FZI technique is that the number of HFUs is identified using qualitative methods and subjective estimation. This work proposes robust methods to identify the optimal HFUs using differential evolution (DE) and two-stage clustering. The first method tested in this work enumerates through a large number of HFUs scenarios using 10 clustering algorithms and different input parameters (number of clusters, minimum number of samples, etc.). The scenario with the largest average correlation coefficient is selected as optimum. The second method uses the DE algorithm to maximize the average correlation coefficient and hence obtain the optimal HFUs. The third method consists of two stages. The first stage uses the OPTICS clustering algorithm to determine the number of HFUs, while the second stage generates the desired clusters using the Gaussian mixture algorithm. Both iterative evaluation and DE optimization methods achieved the same clustering results. However, DE optimization resulted in 85% reduction in runtime due to the robust search capability of the DE algorithm which leads to the solution more efficiently. Furthermore, another significant reduction in runtime was achieved using the two-stage clustering method which yielded very close results. The proposed methods in this work provide unique and potential opportunity to improve the use of FZI data analysis to identify HFUs. This work uses the power of clustering and stochastic algorithms to support a critical process in reservoir characterization.
Experiments on the Novel Chord-Edge Cutter to Break Rock with Higher Efficiency and Its Field Application
Authors: Yang Bo , Kuang Yuchun , Jingpei Zhou , Hu Li , Fan Peng
Published: November 2022

Aiming at the difficulty of penetration in hard-plasticity formation represented by the Mahu oil field, a new type of chord-edge cutter is proposed. Through theoretical derivation and quantitative analysis of specific unit pressure (SUP) and breaking area, the penetration and rock-breaking area of the chord-edge cutter are studied, which clarifies that the rock-breaking efficiency of the chord-edge cutter is higher than that of the conventional cutter. The first part of the laboratory experiment investigated the drilling efficiency of two mini-bits on a special sample. The results show that the chord-edge cutter mini-bit has higher efficiency than a conventional mini-bit. The second part of the laboratory experiment investigated the influence of rate of penetration (ROP), revolutions per minute (RPM), and rock types on the drilling performance of chord-edge cutter mini-bit. The data show that the chord-edge cutter is more suitable for drilling hard-plastic rocks. It also reveals that the higher the RPM, the lower the stick/slip vibration, but the RPM above a certain value will lead to an increase in lateral vibration. ROP and weight on bit (WOB) are positively correlated. And the higher the drilling speed, the higher the stick/slip vibration and lateral vibration. To verify these conclusions, a field test is carried out in the hard-plastic formation of a well in the Mahu. In this test, compared with a conventional polycrystalline diamond compact (PDC) bit, a roller-cone bit, and a hybrid bit, the chord-edge cutter bit has the best drilling effect. Further, it is found that when using the chord-edge cutter bit, the high RPM and proper control of WOB can achieve a better drilling efficiency. This rule is mutually confirmed with the conclusion of the laboratory experiment. After the above research and its implementation, it can be concluded that the novel chord-edge cutter bit can achieve the research goal of higher efficiency, which provides a new idea to overcome challenges in the hard-plastic strata.
Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora goats
Authors: Kul Bengi Cinar , Bilgen Nuket , Biskin Merve , Akkurt Mustafa Yenal , Cildir Ozge Sebnem , Ozmen Ozge , Kul Oguz
Published: November 2022

Background: Mammals have physiological reprogramming adaptation ability to changing seasonal light and temperature, through their biological clocks maintained by circadian rhythm, photoperiodism and thermoperiodism. These seasonal differences do not only affect vital activities of animals like migration, reproduction, sleeping, but also cause dramatic changes in their economically important characters (e.g. fur quality, fattening levels and milk yield). Mohair is constituted of non-medullary hairs produced by secondary hair follicles in Angora goats and the effects of seasonal differences on mohair structure and related genes are still unknown.
Methods and Results: We examined the gene expression levels of BMP-2, FGF-5, HOXC13, KAP9.2 and TGFBR2 normalized with GAPDH in skin biopsies taken from Angora goats (n=20) in two different follicle development stages; telogen and anagen, sampled in February and June, respectively. HOXC13 showed high level of expression in anagen phase whereas expression was undetectable in telogen phase. TGFBR2, FGF-5, and BMP-2 were significantly upregulated in anagen, while KAP9.2 expression showed no difference between two phases.
Conclusions: This is the first study on hair follicle-related genes in the angora goat and revealed that these genes differ between geographic zones and/or breeds. Additionally, we speculate that overexpression of HOXC13 might be one of the underlying factors associated with non-medullary hair nature, making the mohair more shiny and silky in Angora goats.
Treatment for non-type 1 retinopathy of prematurity by intravitreal injection of anti-vascular endothelial growth factor drugs
Authors: Zhang Haitao , Yang Xin , Zheng Fangfang , Yin Xiangke , Wan Suhua
Published: November 2022

Background: To explore clinical characteristics and treatment reasonsfor intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs in the treatment of non-type 1 retinopathy of prematurity (ROP).
Methods: A retrospective study was conducted to screen the non-type 1 ROP from the collected ROP patients who received intravitreal injection of anti-VEGF drugs in Henan Eye Hospital from September 2018 to June 2021.
Results: A total of 138 ROP cases (262 eyes) were included in this study, including 39 cases (28.3%) 65 eyes (24.8%) were the non-type 1 ROP. Compared with the type 1 ROP group, the non-type 1 ROP group had slightly later treatment time (39.8±2.7 weeks vs 38.1±2.6 weeks, P<0.05) and a higher proportion of fusion protein drugs (87.2% vs 54.5%, P<0.05). After intravitreal injection of anti-VEGF drugs, 27 eyes (41.5%) were cured and 38 eyes (58.5%) were improved in the non-type 1 ROP group, without recurrence and aggravation cases. There were more lesions in zone II (63 eyes, 96.9%), with stage 2 (40 eyes, 61.5%) and stage 3 (23 eyes, 35.4%), and 58 eyes (89.2%) showed pre-plus in the non-type 1 ROP group. Treatment reasons included pre-plus in 58 eyes (89.2%), ridge aggravation in 22 eyes (33.8%), simultaneous treatment of the contralateral eye in 9 eyes (13.8%), no regression of lesions in persistent stage 2 or 3 over PMA 44 weeks of follow-up in 8 eyes (12.3%), and logistical considerations in 4 eyes (6.2%).
Conclusions: Considering some peculiar clinical characteristic, treatment by intravitreal injection of anti-VEGF drugs may be considered carefully for some non-type 1 ROP in critical conditions.
Spindle cell melanoma masquerading as a lipoma: an interesting presentation of a rare cancer
Authors: Lamm Ryan , Lyons Walker , Gargano Stacey M , Willis Alliric I
Published: November 2022

Background: Overall survival is directly correlated to melanoma thickness and definitive surgical excision. Spindle cell melanoma is a rare subtype of malignant melanoma and particularly difficult to diagnose. Identification of histopathological features and referral to specialists are essential.
Case presentation: We describe the case of an 86-year-old male who presented to his family medicine physician with complaints of a large 40 mm mass on his right posterior trunk which was clinically diagnosed as a lipoma. This mass was subsequently removed in his family physician’s office as an office procedure. Less than eight months post-excision, the tumor had erupted through the incision site. At time of surgical oncologist evaluation, the tumor was pedunculated and measured 92 mm at its greatest diameter. This tumor was subsequently biopsied to reveal spindle cell melanoma with thickness of at least 22 mm. Wide local excision was performed with complete removal of the tumor with negative margins.
Conclusion: Our report supports the importance of early and correct diagnosis of cutaneous melanoma which can often be mistaken for other cutaneous lesions, both benign and malignant. In these situations, it is important to obtain a tissue biopsy and consult with specialists in pathology and surgical oncology/dermatology to ensure timely, appropriate treatment.
Diabetes during the COVID-19 pandemic: are people getting access to the right level of care?
Authors: Meyerowitz-Katz Gideon , Ferdousi Shahana , Maberly Glen , Astell-Burt Thomas
Published: November 2022

Introduction
Avoidance of health services, in particular hospital and community services, is problematic for people with diabetes. Evidence has demonstrated that such missed attendances are associated with worse health, faster declines in functioning, and higher rates of mortality long-term.
This paper investigated the impact of the pandemic on healthcare access across community and hospital care, including Virtual Care (VC) using several large datasets of General Practice (GP) and hospital services in western Sydney.
Methods
A retrospective cohort study using a time-series database of 173,805 HbA1c tests done at Blacktown and Mt Druitt hospitals and 1.8 million recorded consultations at GP clinics in the region was undertaken.
Results
The average rate of diabetes in Emergency Department fell from 17.8% pre-pandemic to 11% after January 2020 (p<0.001). This rate varied substantially over time, and correlated well with large outbreaks of COVID-19 in the state. Conversely, attendances of people with diabetes to GP clinics, especially using VC services, increased substantially over the pandemic period.
Discussion/Conclusion
During the pandemic there was a substantial avoidance of hospital care by patients with diabetes. However, this may have been replaced by VC offered in the community for those with less severe diseases.