bluuebunny/crossref_metadata_2025 huggingface dataset:
Constraining the timescales of mafic magmatism of the Central Karoo Large Igneous Province using high precision U-Pb zircon geochronology
Authors: Muedi T. , MacLennan S. , Szymanowski D. , Schoene B. , Ramezani J. , Oalmann J. , Linol B.
Published: March 2022

Recent U-Pb high-precision geochronological studies have shown rapid emplacement of the intrusive doleritic component of the Karoo Large Igneous Province (KLIP) in Southern Africa. However, these studies focused on a relatively small geographic and altitudinal region of the KLIP. Additionally, the timing of initiation of extrusive volcanism, preserved in the Drakensberg-Lesotho highlands and its relationship to the intrusive suite, has only been imprecisely constrained by Ar-Ar dates. Here, we present new high-resolution U-Pb zircon ages on dolerite sills and dykes from across the central eastern Karoo Basin (South Africa) at elevations between mean sea level and 1 560 m, as well as U-Pb detrital zircon data that can be used to estimate the maximum age of volcaniclastic deposition near the base of the extrusive component of the KLIP. Dolerite samples were taken across two areas: (1) thick dykes exposed along the coast of the Indian Ocean to ~1 600 m flanking the Drakensberg Escarpment in the Eastern Cape; and (2) sills between 20 and 220 m below surface, in a borehole core within the interior of the Karoo Basin, 400 km hinterland from the coastline. Our estimated dolerite emplacement ages span a range of ca. 80 thousand years (Kyr), between 183.122 ± 0.029/-0.061 and 183.042 ± 0.042/-0.072 million years ago (Ma), and fall within the 331 +60/-54 Kyr age range previously established for magmatism related to the KLIP, despite the marked increase in sampling coverage in terms of area and altitude in this study. Therefore, KLIP geochronology is consistent with other LIPS such as the Siberian and Deccan Traps that supports the hypothesis of rapid emplacement timescales (<1 Myr). Additionally, these data are consistent with, but better delineate that the KLIP in southern Africa appears to be ca. 500 Kyr older than the main phase of magmatism in the Ferrar LIP of Antarctica. Detrital zircons from the basal volcanic sequence of the Drakensberg Group exhibit age peaks at ca. 1 and 0.5 Ga, typical of the surrounding Namaqua-Natal and Pan-African basement rocks, as well as younger peaks at ca. 260 and 200 Ma that likely relate to source provenances from south-western Gondwana and reworking of the Karoo Supergroup sedimentary rocks. High-precision U-Pb dates of the youngest zircon grains result in a maximum depositional age for the basal pyroclastics of 185.25 ± 0.25 Ma, allowing for a ca. 2 Myr offset with the intrusive Karoo dolerite suite.
Multi-Criteria Approach to Assessing the Investment Attractiveness of Innovative Projects
Authors: Obuhova E. A.
Published: March 2022

Realistic evaluation of the investment attractiveness of the financed project is the basis for the successful functioning of a venture investor. At the same time, investors often have to act in conditions of a severe lack of information, especially when it comes to projects at an early stage of the life cycle. In these cases, they use multi-criteria methods for assessing investment attractiveness, often also called scoring methods. The aim of this work is to develop a methodology for assessing the investment attractiveness of innovative projects at the early stages of the life cycle, both based on an analysis of theoretical approaches in the field of venture economics, and based on an analysis of existing business practices.We have proposed a method for assessing the investment attractiveness of a project based on dividing the criteria into three macro groups (market and entry strategy, team and product). At the same time, we used a concept that allows us to interpret the value of each of the assessed parameters (seven in each macro group) as a positive or negative signal given by the project to a potential investor.An important difference between the presented methodology and others described in the professional literature is the combination of the use of theoretical models with an in-depth analysis of the criteria used in practice by various players in the venture capital market (funds, business angels, etc.), which together form the methodological basis of the work. This combination of the use of sources of information on the criteria for evaluating projects determines the scientific novelty of the study. The practical significance lies in the possibility of applying the proposed methodology both by venture investors and other actors of the venture capital ecosystem for making specific financial decisions.
Untersuchung der thermisch-oxidativen Stabilität von Gasölen mittels Druckdifferenz-Kalorimetrie (PDSC)
Authors: Zanier Adriano , Debrunner Urs , Jäckle Hans W.
Published: March 2022

Thermoanalytical techniques have found widespread use as a quality-control tool for petroleum and related products. Pressure differential scanning calorimetry (PDSC) has been effectively used as an alternative method to estimate thermal-oxidation stability of middle-destillate fuels. In this paper, the fuels were rated on thermal stability on the basis of their enthalpy of the exothermic reaction 'Oil + O2 → Oxidation Products' under isothermal conditions. The thermograms before and after a certain period of time under thermal-oxidative strain have been compared in order to determine the average heat flow during that period and, therefore, to obtain an indication to fuel storage stability. Six heating oils of diverse composition and origin were selected for the investigation. On the basis of these examples a correlation between the physical-chemical properties and the DSC data has been shown and the factors influencing the thermal-oxidation stability have been evaluated. The reliability of the method with regard to predicting long-term storage stability has been discussed.
Molecular Devices Based on Bridged Transition-Metal Complexes
Authors: Belser Peter
Published: March 2022

The article from A. von Zelewsky, in this issue gives a broad survey about some scientific activities at the Institute of Inorganic Chemistry of the University of Fribourg. The present contribution will be rather focused on a detailed study of the photophysical and photochemical
behavior of a molecular device that is capable to undergo energy- and/or electron-transfer processes.
Catabolism of Tetrapyrroles
Authors: Gossauer Albert
Published: March 2022

The enzymatic degradation of naturally occurring tetrapyrrolic pigments (heme, chlorophylls, and vitamin B12) is shortly reviewed.
Tributyl[2-(trimethylsilyl)-prop-2-enyl]stannane: A Highly Efficient Reagent for the Allylation of Radicals
Authors: Renaud Philippe , Gerster Michèle , Ribezzo Marco
Published: March 2022

Allylation rates of radicals with tributyl[2-(trimethylsilyl)prop-2-enyl]stannane (2) have been compared with the ones of the (prop-2-enyl)stannane (3) and [2-(methyl)-prop-2-enyl]stannane (4). The Me3Si substituent showed a rate-accelerating effect (4.2:1 to 6.5:1) relative to the H-atom and the Me group for nucleophilic radicals. With electrophilic radicals, the Me group has a better rate accelerating effect than the Me3Si group. All these results can be understood by postulating a partially polarized transition state. The 1-substituted vinylsilanes which are produced by radical allylation with 2 have been converted by protiodesilylation and ozonolysis to alkenes and α-hydroxy ketones.
'Physikalische Chemie' an der Universität Freiburg i. Ue.
Authors: Haselbach Edwin
Published: March 2022

The development of Physical Chemistry at the University of Fribourg/Switzerland is described since the foundation of its Faculty of Sciences in 1896.
Sidedness of Biosynthesis of Glycosylphosphatidylinositol Anchors in the Endoplasmic Reticulum of Saccharomyces cerevisiae
Authors: Djafarzadeh Siamak , Conzelmann Andreas
Published: March 2022

Many surface membrane glycoproteins of eucaryotes are attached to the membrane by a glycosylphosphatidylinositol (GPI) anchor. Biosynthesis of these anchors proceeds through two stages. First, the synthesis of the protein and of a free glycosylphosphatidylinositol (GPI) is achieved separately. In a second step, the protein is hooked onto the preformed free GPI whereby a provisional C-terminal hydrophobic peptide is removed. The GPI-anchored protein is subsequently transported to the cell surface by way of vesicular traffic. It is presumed that the attachment of the preformed free GPI's to proteins occurs on the luminal surface of the endoplasmic reticulum (ER). The stepwise addition of sugars by glycosyltransferases onto phosphatidylinositol to form a free GPY is equally presumed to occur in the ER, but it is unclear whether these reactions take place at the cytosolic or the luminal side of the membrane. Here we tried to get some information on the membrane orientation of free GPYs in Saccharomyces cerevisiae surmising that their orientation might tell us something about the probable location of the biosynthetic process. When using trinitrobenzenesulfonic acid as a probe, we find that 75% of the free GPIs in intact ER-derived microsomes get derivatized, whereas 100% get derivatized in detergent-permeabihzed microsomes. This finding is compatible with the idea that in yeast lipid anchors are built up at the cytosolic surface.
Analyse d'un chromatogramme
Authors: Naef Olivier
Published: March 2022

A program for peak detection in chromatograms has been developed using Labview 3.0 which is a modern object oriented graphical programming language that can be operated on many different platforms. The peak detection is based on the calculation of the first derivative. To determine
the limits of this peak detection, computer-simulated chromatograms have been used which is less time consuming than using experimental data.
Analyse des β-agonistes à l'aide de colonnes d'immuno-affinité par CPG/SM
Authors: Jeannet Cyril , Rohrbasser Claude
Published: March 2022

β-Agonists are used in human and veterinary medecine. These chemicals are active at very low concentration (μg/kg meat), causing analytical problems of quantification. The purpose of this work was to develop and test a new analytical method using the principle of immunoselectivity.
Antioxidants for Industrial Applications
Authors: Pitteloud Rita , Dubs Paul
Published: March 2022

The thermooxidative degradation of organic materials as well as its inhibition by classical and nonclassical antioxidants are briefly outlined.
Organic Corrosion Inhibitors
Authors: Kramer Andreas , Wolf Jean-Pierre
Published: March 2022

Organic corrosion inhibitors, which are used as additives in paints and lubricants to provide permanent corrosion protection, are briefly discussed.
Taking Lithography to the Third Dimension
Authors: Bernhard Paul , Hofmann Manfred , Schulthess Adrian , Steinmann Bettina
Published: March 2022

Stereolithography is a new technology which allows the rapid building of plastic models directly from CAD data. The photopolymers needed for this process are developed at Ciba's research center in Marly by a project team from the Polymers Division and the corporate Materials
Research. The stereolithography process is described as well as the requirements for the photosensitive monomer formulations. Two types of stereolithography resins have been developed so far: acrylate mixtures which polymerize by a radical mechanism and epoxy-based formulations which are cured
cationically. The acrylate resins polymerize very rapidly and several formulations with different mechanical properties are available. Cationic resins are a development of the past two years. They are less photosensitive than the acrylates, but have other advantages, such as low viscosity,
high green strength and very high dimensional accuracy. With these resins, parts can be built which can be used directly as patterns for the investment casting process.
Colored Systems with Improved Weatherfastness
Authors: Chassot Laurent
Published: March 2022

Weatherfastness of pigmented organic coatings is a classical problem in the industrial world. We describe the photoreactivity of some heterocyclic pigments from the 1,4-dioxopyrrolo[3,4-c]pyrrole (DPP) family in suspension and in a polymer matrix, and the discovery of the photostabilization
of organic crystals by nitroxy radicals.
Electron-Microscopy Investigations of the Warping Effect in Pigmented High Density Polyethylene
Authors: Bugnon Philippe , Boéchat Jean-Marc , Dudler Vincent , Merian Daniel
Published: March 2022

The warping effect of high-density polyethylene (HDPE) articles produced by organic pigmentation has been studied by scanning electron microscopy. A warping pigment and its warp-free analogue obtained by surface treatment have been observed and compared to an inorganic warp-free pigment.
The results indicate that the generally accepted nucleation theory is not sufficient to describe fully the warping effect. An attempt is made to describe this effect in terms of pigment-polymer compatibility.
ANALISIS PERBANDINGAN PERILAKU STRUKTUR GEDUNG DENGAN KOLOM KOMPOSIT DAN KOLOM NON KOMPOSIT
Authors: Nursani Rosi , Al Huseinny Mohammad Syarif
Published: March 2022

Kolom merupakan salah satu komponen struktur utama dalam sebuah bangunan gedung yang berfungsi sebagai pemikul beban dari bagian atas dan meneruskannya sampai ke pondasi. Kekuatan sebuah gedung sangat didipengaruhi oleh kekuatan kolom. Kolom harus memiliki kapasitas yang baik diantaranya tahan terhadap bahaya tekuk akibat pembebanan. Desain kolom menjadi salah satu hal yang harus diperhatikan agar memiliki kapasitas yang sesuai dengan pembebanan. Dalam perkembangan saat ini, kolom tidak hanya menggunakan material beton atau baja saja akan tetapi banyak digunakan material komposit baja-beton. Material komposit baja-beton digunakan dengan tujuan untuk mendapat kombinasi keuntungan dari kedua material yaitu baja dan beton sehingga dapat meningkatkan kapasitas kolom. Oleh karena itu, penelitian ini bertujuan untuk menganalisis perilaku gedung dengan menggunakan kolom komposit dan non komposit. Penelitian dilakukan dengan memodelkan gedung yang sama dengan variasi kolom yang berbeda yaitu kolom dengan menggunakan material beton, baja dan komposit beton-baja. Gedung yang dimodelkan merupakan gedung 6 lantai dengan dimensi, peruntukan gedung dan pembebanan yang sama yaitu gedung rumah sakit. Hasil penelitian menunjukkan bahwa kolom komposit pada penelitian ini memiliki kapasitas terhadap momen dan geser yang lebih besar dari pada kolom nonn komposit
The Composition of Oxygen Functional Groups on Graphite Surfaces
Authors: Intan Nadia , Pfaendtner Jim
Published: March 2022

The types and compositions of oxygen functional groups on graphite surfaces are heavily subjected to the method in which the graphite is synthesized and processed in experiments, which makes the characterization difficult. The challenge even extends to the modeling of oxygenated graphite surfaces in computational studies. However, determination of both the types and composition of oxygen functional groups on graphite surfaces is of paramount importance as it plays a significantly important role in dictating the behaviors and performances of electrochemical systems. For example, the surface structure and composition of the graphitic anode used in lithium-ion batteries (LIBs) determines the quality of a solid electrolyte interphase (SEI) that forms at the electrode/electrolyte interface, which in turns substantially affects the stability and lifetime of the devices. To help predict the structure and the composition of the surface oxygen functional groups on graphite surfaces resulting from solution-based synthesis and modification processes, we analyze the adsorption of different oxygen functional groups at both edge and basal sites of graphite as a function of pH under which the solution-based processes may take place. A series of DFT calculations reveal that at room temperature and for a pH range from 0 to 14, the (112 ̅0) edge surface of graphite will be fully oxygenated, while the basal sites remain unsaturated. The oxygen functional groups at the edge sites are comprised of mostly hydroxyl and ketonic groups, with carboxyl and carbonyl groups are present only in small amounts. Furthermore, we observe transformation of carbonyl group into ketonic group in the presence of empty surface carbon sites, which further stabilize the graphite surface. Meanwhile, carboxyl groups are more stable when all surface sites within a carboxyl layer are all populated. We conclude that the population of oxygen groups that can be found at the edge surface of a graphite in the ascending order are carboxyl < carbonyl < hydroxyl < ketonic. On the contrary to the edge plane, a small amount of oxygen functional groups may be forced to adsorb on the basal surface upon application of an external potential. The adsorbed groups are found to prefer to cluster together on basal sites in a highly ordered fashion, while the edge surface does not show this preference for adsorption sites.
Installation of cysteine-derived methyllysine mimics on phage-dis- played peptide libraries: optimization of reaction conditions for conversion and phage viability
Authors: Milosevich Natalia , Vizely Katrina H. , Nikolic Roko P.A. , McCallum Jacob F. , Treanor Lee M. , Khan Sarah S. , Derda Ratmir , Hof Fraser
Published: March 2022

We report a synthetic methodology for the installation of methyllysine mimics on cysteine-containing peptides and bacteriophage peptide libraries. Strategies that allow for diversity and high throughput screening of PTM-containing peptides are critical for successfully targeting the many methyllysine reader proteins that are misregulated in cancer and disease. We have de- veloped conditions for alkylation of cysteine containing peptides with (2-haloethyl) amines, providing products that closely mimic methyllysine residues. Extensive optimization on C7C peptide phage constructs allowed for the successful installation of Kme3 mimics in 60–70% yields to create post-translational ε-Lys-N-methylated peptide phage libraries. Optimized reaction conditions between 2-bromo-N,N,N-trimethylethaninium bromide and commercially available PhD C7C library produce >2 × 1011 phage parti- cles and libraries of ~2 × 108 diversity in which each peptide sequence contains the Kme3 mimic. This process adds a new fragment into readily available genetically encoded libraries and opens new avenues for high throughput screening that may give rise to new ligands for a variety of methyllysine reader proteins.
Discovery of Amino Acid fingerprints transducing their amphoteric signatures by field-effect transistors
Authors: Kumar Naveen , Dhar Rakshita Pritam Singh , García César Pascual , Georgiev Vihar
Published: March 2022

Protein sequencing is a key to many of the biological fields to advance science at the sub-atomic level. However, even with advanced techniques such as mass spectrometry, the fluctuations in the amino acids/genes are hard to comprehend. We are presenting something new and disruptive related to FET-based sensors for single amino acid/polypeptide detection with the effect of redundant reactive sites and reduced noise. We have used a modified site-binding model in self-consistency with the Gouy-Chapman-Stern model to express the fingerprints of a single amino acid or polypeptide mutation. Surface potential, 2nd gradient of the surface potential (δΨ2/δpH2) and total surface capacitance are used as fingerprint signals to differentiate between the amino acids including the drain current variation as the signal transduction. A novel noise-filtering technique is proposed using the Fast-Fourier Transform and derived analytical model solved iteratively to smoothen the experimental data while reducing the possible data loss. The minimum pH resolution of δΨ2/δpH2 is 0.1 and the minimum capacitance resolution is 0.01mF/m2 for differentiating the AAs or polypeptides. The effect of noise (>SNR=10dB) and silanol sites can be negated by correlating the AAs signatures from δΨ2/δpH2 and capacitance. Thus, the designed methodology and approach can help immensely in designing a new and efficient tool for protein sequencing while solving the problems related to the signal transduction of sensors.
DeepWEST: Deep learning of kinetic models with the Weighted Ensemble Simulation Toolkit for enhanced kinetic and thermodynamic sampling
Authors: Ojha Anupam , Thakur Saumya , Ahn Surl-Hee , Amaro Rommie
Published: March 2022

Recent advances in computational power and algorithms have made molecular dynamics (MD) simulations reach greater timescales. However, for observing conformational transitions associated with biomolecular processes, MD simulations still have limitations. Several enhanced sampling techniques seek to address this challenge, including the weighted ensemble (WE) method, which samples transition between metastable states using many weighted trajectories to estimate kinetic rate constants. However, initial sampling of the potential energy surface has a significant impact on the performance of WE, i.e., convergence and efficiency. We thereby introduce deep-learned kinetic modeling approaches that extract statistically relevant information from short MD trajectories to provide a well-sampled initial state distribution for WE simulation. This hybrid approach overcomes any statistical bias to the system as it runs short unbiased MD trajectories and identifies meaningful metastable states of the system. It is shown to provide a more refined free energy landscape closer to steady-state that could efficiently sample kinetic properties such as rate constants.
Emerging Era of Biomolecular Membrane Simulations: Automated Physically-Justified Force Field Development and Quality-Evaluated Databanks
Authors: Antila Hanne S. , Kav Batuhan , Miettinen Markus S. , Martinez-Seara Hector , Jungwirth Pavel , Ollila O. H. Samuli
Published: March 2022

Molecular simulations of biological membranes and proxies thereof are entering a new era characterized by several key aspects. Progress starts with the realization that the outcome of the simulations can be only as good as the underlying force field and we actually need to know precisely how good or bad the results are. Therefore, standardized procedures for data quality evaluation are being established and will be applied to biomembrane simulations available in the literature. This provides the necessary basis and impetus for new force field development. Here, we propose to systematically build up physically well-justified models which effectively account for electronic polarization effects for all components of the biomembrane systems in aqueous environments. Such a massive task can only be achieved within a reasonable timescale by applying automated parameterization tools.
The Effect of Creative Drama-Based Psycho-Education Program on Emotional Intelligence of Adolescents
Authors: AKYIL Yusuf , DENİZ M. Engin
Published: March 2022

The aim of this study was to analyze the influence of the creative drama-based psychoeducation program in adolescents on their emotional intelligence level. For this purpose, a true experimental design with pretest-posttest groups was used. The study group of the research consisted of 16 experimental, 16 control and 16 placebo group 12th grade students who are in a public high school in Avcılar, Istanbul. 20-sessions drama-based education program, two sessions per week for 10 weeks, was applied to the experimental group, while film and 10 academic education seminars were applied to the placebo group, and was no application to the control group. Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF) has been applied to all groups. Before the study, data related to the pre-test application of the scale was analyzed with the Kruskal Wallis-H test and it was determined that there was no significant difference between the groups. A meaningful result was found among the groups in favor of the experimental group. This result showed that the creative drama-based educational program increases students’ emotional intelligence levels. In this context of the result, using the creative drama method in education and training activities can be suggested.
The Relationship Between Women's Self-Confidence, and Conspicuous Consumption Tendency on Social Media
Authors: ETİ Hasan Selçuk
Published: March 2022

This study aims to examine the relationship between women's self-confidence and conspicuous consumption tendency on social media. The research was designed in a relational screening model. The study sample consists of 311 university students reached by a simple random sampling method. A questionnaire form was used to collect data in the research. The questionnaire form consists of a demographic information form, self-confidence scale, and conspicuous consumption scale. Within the scope of the study, descriptive statistical analyses, correlation analyses, regression analyses, t-tests and ANOVA analyses were conducted. As a result of the analyses, it has been determined that self-confidence has negative and significant effects on conspicuous consumption. In addition, it has been determined that self-confidence differs significantly according to marital status, and income and conspicuous consumption differs significantly according to marital status. In terms of firms and policymakers, the self-confidence of individuals has been concluded that it is an essential factor that determines the purchasing behavior of consumers. In this context, another crucial point is that individuals with high self-confidence have relatively fewer demands for conspicuous consumption.
An empirical study on the various stock market prediction methods
Authors: Pandya Jaymit Bharatbhai , Jaliya Udesang K.
Published: March 2022

Investment in the stock market is one of the much-admired investment actions. However, prediction of the stock market has remained a hard task because of the non-linearity exhibited. The non-linearity is due to multiple affecting factors such as global economy, political situations, sector performance, economic numbers, foreign institution investment, domestic institution investment, and so on. A proper set of such representative factors must be analyzed to make an efficient prediction model. Marginal improvement of prediction accuracy can be gainful for investors. This review provides a detailed analysis of research papers presenting stock market prediction techniques. These techniques are assessed in the time series analysis and sentiment analysis section. A detailed discussion on research gaps and issues is presented. The reviewed articles are analyzed based on the use of prediction techniques, optimization algorithms, feature selection methods, datasets, toolset, evaluation matrices, and input parameters. The techniques are further investigated to analyze relations of prediction methods with feature selection algorithm, datasets, feature selection methods, and input parameters. In addition, major problems raised in the present techniques are also discussed. This survey will provide researchers with deeper insight into various aspects of current stock market prediction methods.
Progress of TCM Syndrome Differentiation and Treatment of Hypertension with Sleep Disorders
Authors: Kou Linli , Zhao Mingjun
Published: March 2022

It has been discovered that the number of hypertensive patients with various types of sleep disorders is on the rise, which significantly increases the morbidity and mortality of cardiovascular diseases. Modern medicine has not reached a consensus on the mechanism and treatment of these diseases but relies on drugs to improve sleep disorders and blood pressure. We regard TCM syndrome differentiation as the breakthrough point, along with comprehensive modern and traditional medical methods based on dialectical thinking as means of holistic and symptomatic treatment of Western medicine integrated with the eight principles of TCM diagnosis, Zang-Fu organs, six meridians, Qi, blood and fluid, as well as other dialectical methods, in order to provide a broader idea for TCM treatment and lay a foundation for further and better development of integrated TCM and Western medicine treatment.
Ontology of Congenital Spine Defects
Authors:   Bukovinian State Medical University, 1a, Aksenyna Str., apt. 16, Chernivtsi 58001, Ukraine, Komar T. V. , Khmara T. V. , Kovalchuk P. Ye. , Ryznychuk M. O. , Biriuk I. G. , Zamorskii I. I.
Published: March 2022

Deepening and generalization of existing knowledge about rare diseases and congenital anomalies are becoming relevant in modern medical practice. Understanding the features of prenatal morphogenesis of the spine and spinal cord, as well as postnatal changes of the cartilaginous spine, is necessary to interpret the severity of pathologies and predict their complications. The purpose of the study was to analyze and summarize the information of sources of scientific literature on the congenital spine development defects, their classification and interpretation in alphabetical order. This study is a continuation of our previous studies on the congenital development defects of the human skeleton. The embryological development of vertebrae is complex, so errors in the laying and formation of their basic structures can lead to various types of congenital malformations. Disorders of the spine are associated with changes in the number of vertebrae (occipitalization, thoracolization, lumbalization, sacralization); change in the shape of the vertebrae: vertebrae or wedge-shaped vertebrae (with developmental delay in the anterior parts), spondylolysis (with delayed development of the vertebrae in the posterior parts); impaired development of arches and vertebral bodies. Congenital malformations of the spine can be single, multiple, or mixed. Spinal abnormalities are not always noticeable at birth; they may manifest during growth in the form of deformities or neurological disorders. Common spinal deformities are scoliosis, kyphosis, lordoscoliosis or kyphoscoliosis. In addition to congenital malformations of the spine, a number of concomitant abnormalities should be considered, such as thoracic, intravertebral, cardiac, and urogenital. The severity of congenital malformations of the spine is divided into moderate (require serious treatment, but not life-threatening); severe (to save the child's life, it is necessary to urgently carry out treatment); lethal (incompatible with life anomalies, the child dies during childbirth or in the womb). Conclusion. Treatment of congenital malformations of the spine is long and comprehensive, requires a clear plan and the involvement of specialized specialists, including pediatric orthopedists and neurosurgeons. Based on the analysis of literature sources, an attempt was made to summarize the existing information on congenital malformations of the spine and their classification and interpretation according to the alphabet was proposed
Erythrocytes and Their Importance in the Pathogenesis of Community-Acquired Pneumonia
Authors:   Kharkiv Medical Academy of Postgraduate Education. 195, Moskovsky Ave., Kharkiv 61037, Ukraine, Bereznyakov V. I.
Published: March 2022

The purpose of the study was to study the response of erythrocytes in patients with community-acquired pneumonia and to assess its importance in the pathogenesis of this disease. Materials and methods. Thirty patients with community-acquired pneumonia were examined. The diagnosis was established on the basis of epidemiological, clinical, laboratory, radiological data. Erythrocyte count, hemoglobin concentration, hematocrit number, erythrocyte indexes were determined: mean erythrocyte volume, mean hemoglobin content in erythrocyte, mean hemoglobin concentration in erythrocyte. Results and discussion. It is established that with community-acquired pneumonia in the body there is an increase in the formation of reactive oxygen species at all times of observation. The study of the qualitative and quantitative composition of blood cells in our study found significant shifts in all indicators. Thus, the number of erythrocytes on the 1st day of observation increased by 20.9% relative to the group of healthy individuals, and then decreased and remained by 8 % – 10 % less than in the control on the 5th day. Subsequently, after 10 days there was a sharp (2.2 times) decrease in the number of erythrocytes. However, in general, the concentration of erythrocytes in this observation period remained significantly reduced relative to the group of almost healthy individuals by 20%. Changes in hemoglobin concentration had a similar dynamic. The maximum decrease in erythrocytes count and hemoglobin concentration in the blood over time indicates active hemolysis of erythrocytes during this period. Hematocrit in the examined patients increased sharply on the 1st day of the study, which indicated blood clotting. However, on day 5, hematocrit decreased sharply, amounting to only 57% of the level of the practically healthy individuals’ group and practically did not recover to the ascending level on the 10th day. The mean erythrocyte volume did not change significantly during the study. Conclusion. Changes in the number of erythrocytes, hemoglobin and erythrocyte indices in community-acquired pneumonia are due to membrane-destructive processes in erythrocytes, a decrease in their absolute number – due to hemolysis, hematocrit changes – due to redistribution of blood and hypoxia that develops in non-hospital pneumonia. Changes in erythrocytes are oxygen-dependent mechanisms in the pathogenesis of community-acquired pneumonia
PENGARUH ATRAKSI WISATA, AMENITAS DAN AKSESIBILITAS TERHADAP KEPUTUSAN BERKUNJUNG PADA OBJEK WISATA RELIGI MAKAM KH. ABDURRAHMAN WAHID
Authors: Muharromah Gabriele Lailatul , Anwar Moch Khoirul
Published: March 2022

Every year, the number of tourist visit religious tourist attraction, KH. Abdurrahman Wahid cemetery increases. The tourist decision to visit a tourist attraction place can be influenced by several factors, such as tourist attractions, amenities and accessibility. The purpose of this research is to know the impact of tourist attractions, amenities, and accessibility to the decision of visit on the religious tourism KH. Abdurrahman Wahid cemetery. The research methods used are quantitative research and used multiple linear regression analyses. The results showed that tourist attraction variables and accessibility variables were positive and significant to the visiting decision. But the variable of amenities had no significant effect on the visiting decision. Simultaneously variable tourist attractions, amenities and accessibility affected the variable of visiting decisions.
ANALISIS RESPON PELAKU USAHA MINUMAN KOPI (COFFEE SHOP) TERHADAP KEWAJIBAN SERTIFIKASI HALAL
Authors: Ahmad Brilliant
Published: March 2022

Pemerintah mengesahkan UU JPH yang telah berlaku pada Oktober 2019. Undang-Undang tersebut menegaskan bahwa produk yang beredar, masuk, dan dijual belikan di Indonesia wajib bersertifikasi halal. Berbagai macam jenis minuman kopi sangatlah beragam dan kebanyakan dari produk-produk yang beredar belum mendapatkan sertifikat halal dikarenakan kesadaran akan produk bersertifikasi halal para pelaku usaha masih sangat rendah. Tujuan penelitian ini untuk mengetahui respon dari pelaku usaha coffee shop mengenai kewajiban sertifikasi halal yang telah berlaku di Indonesia mengingat rendahnya kesadaran pelaku usaha terhadap produk halal. Penelitian ini dapat dijadikan sebagai solusi dalam menghadapi masalah tentang kewajiban sertifikasi halal. Metode penelitian yang digunakan oleh peneliti adalah kualitatif bersifat deskriptif, yakni melalui data yang telah diperoleh dan dikumpulkan. Kesimpulan dari penelitian ini menunjukkan respon yang dikeluarkan oleh para pelaku usaha sangat mendukung adanya kewajiban sertifikasi halal tersebut, namun adanya masalah dalam implementasi UU JPH membuat para pelaku usaha masih enggan untuk melakukan sertifikasi halal.
HUBUNGAN PENGETAHUAN, RELIGIUSITAS, DAN LINGKUNGAN SOSIAL TERHADAP MINAT MENABUNG MENGGUNAKAN BANK SYARIAH
Authors: Khairunnisa Isma Aulia , Cahyono Hendry
Published: March 2022

Islamic banks still have obstacles, one of which is the low level of public awareness, especially traders regarding Islamic banks, with the proven traders who still conduct transactions through conventional banks and even individuals (daily banks). Therefore, this study was conducted to determine whether or not there is a relationship between knowledge, religiosity, and social environment on the interest to save using Islamic banks. The method of this research is quantitative with an associative approach. The number of sample as 70 respondents with data collection methods using questionnaires and interview. Purposive sampling is a technique for sampling. The data analysis uses multiple correlation test, T test, F test, and coefficient of determination test (R2). The results of this research are that there is a positive and significant relationship between variables of knowledge and social environment on saving money interest using Islamic banks with tcount  values of 2.014 and 2.913. While the religiosity variable does not have a significant relationship to the interest in saving money using an Islamic bank with a tcount of 0.655. The coefficient of determination test (R2) gets a result of 23%, it means that the variables of knowledge, religiosity, and social environment only have a role of 23% of interest in saving using Islamic banks and the rest is controlled by other variables that is not tested in this study.
SHARIA PROPERTY PURCHASE DECISION WITHOUT BANK: ANALYSIS OF THE INFLUENCE OF PRICE FACTORS, ENVIRONMENT AND RELIGIOSITY
Authors: Al Qorni Galuh Finna Wais , Juliana Juliana
Published: March 2022

The increasing population in Indonesia will have an impact on the increasing need for life, one of which is the need for a home. KPR also comes with a sharia system without involving banks to meet the needs of the community in owning a house better known as Sharia Property. Therefore, the purpose of this research is to analyze whether there is an influence of price, environmental and religiosity factors on sharia property purchase decisions in Indonesia. The research method used is descriptive quantitative with technical data analysis using SEM-PLS method. The data of this research is processed from sharia property consumers in Indonesia amounting to 110 people. The results showed the price level, environmental level and religiosity level are in a high category. All of these variables have a positive influence so that it can influence sharia property purchase decisions. This research is expected to provide benefits for various parties in improving public understanding of Sharia property in order to improve development strategies in sharia property purchase decisions in Indonesia.
IMPLEMENTASI STRATEGI ISLAMIC MARKETING MIX PADA KOKUMI TRANSMART RUNGKUT SURABAYA
Authors: Nurfaizah Fatima Carmitha
Published: March 2022

Wide competition causes the need for a marketing strategy that can make its business grow, one of which is the 4P marketing mix (product, price, place, and promotion) as a marketing tool, which will then have an influence on the sales volume owned by the company. The focus of this research is the implementation of the 4P marketing mix strategy at Kokumi Transmart Surabaya which is associated with conformity based on sharia principles. This type of research uses field research, in which to obtain data using interviews, observation, and documentation. This understanding uses a qualitative approach. The conclusions in this study indicate that the implementation of the marketing mix carried out by Kokumi Transmart Rungkut is in accordance with Islamic principles and principles, as evidenced by the condition of the product which does not contain intoxicating elements for consumers and also does not contain pork, for pricing Kokumi provides competitive prices and adjusts From the quality level given, promotional activities are also carried out well, there is no act of cheating or even trying to overthrow other competitors, and in organizing the venue, Kokumi has provided a comfortable and safe place for its consumers.
Pengaruh Penyaluran Dana Zakat Produktif Terhadap Pendapatan Mustahiq Pada Lembaga Manajemen Infaq Perwakilan Jawa Timur Di Surabaya
Authors: Rahayu Dea Putri , Anwar Moch. Khoirul
Published: March 2022

One of the economic problems in society is low income. Economic problems in society often show negative impacts on social life such as poverty, unemployment, so that it can have an impact on low education levels and low income. One of the ways to overcome the problem of poverty is by means of zakat and waqf which are the teachings that exist in Islam as contained in the letter Al-Baqarah: 43. The potential for zakat in Indonesia is quite large in the economy of the people. Based on BAZNAS research, the national zakat potential reaches IDR 217 trillion. This study aims to determine the distribution of productive zakat funds made by the Infaq Management Institute and its effect on mustahiq income. This study uses a quantitative approach. The results showed that the variable productive zakat funds had a positive and significant effect on the mustahiq income variable.
PENGARUH PENERAPAN GOOD CORPORATE GOVERNANCE TERHADAP KINERJA KEUANGAN BANK UMUM SYARIAH DI INDONESIA
Authors: Amelinda Tiara Novia , Anwar Moch Khoirul
Published: March 2022

The development of the sharia banking industry is increasingly diverse, with many sharia products and services, with good corporate governance that is important to practice. The purpose of this study is to prove whether or not there is an effect of the implementation of Good Corporate Governance on financial performance. The type of research used is quantitative with an associative approach and secondary data. Purpose sampling technique is used as a sampling technique. Sources of data taken using secondary data are time series obtained from the company. The data analysis technique in this research uses data analysis in the form of panel data. The study found that only the audit committee board has a significant effect on financial performance. Meanwhile, other results prove that good corporate governance has a significant role in the company's financial performance.
Pengaruh Kompensasi terhadap Kinerja Karyawan melalui Kepuasan Kerja sebagai Variabel Intervening di Bank Rakyat Indonesia Syariah Sidoarjo
Authors: Wulandari Feni , Cahyono Hendry
Published: March 2022

Along with the times. The Islamic banking industry in Indonesia is growing rapidly. This makes competition between organizations or industries very fierce. The organization that already to be able to compete if the organization pays attention to the performance of its employees. This research aims to determine the effect of compensation on employee performance through job satisfaction of employees of Bank Rakyat Indonesia on Sidoarjo branch. This research design uses quantitative and causal associative with primary and secondary data sources. Classical Assumption Test and Path Analysis were chosen as data analysis methods. With this method, the results obtained have a significant direct effect of compensation on employee performance and indirect effect of compensation on employee performance through job satisfaction.
KEMANDIRIAN DAN PEMBERDAYAAN EKONOMI BERBASIS PESANTREN (Studi Kasus pada Pesantren al-Amanah Junwangi Krian)
Authors: Sugiono Mohammad Arif Agus , Indrarini Rahma
Published: March 2022

Pesantren can't be separated from its contibution to educate society, an organization in which was established to be the center of education, religion, culture, and people's economy. Pesantren is one of the empowering institutions and to empower people. This research aims to indentify the potential in pesantren as an independent institution economically and is able to empower people economically. The method used in this research is descriptive qualitative method  by using case study approach. The data collection techinques used were interview, observation, and documentation. The concept of modern independent pesantren of Al-Amanah Junwangi  was institutional potential optimization of pesantren itself, without ignoring the concept of pesantren which holds independence in educationg the students. Pesantren is not actually a profit organization, but it can develop itself and provide economical impacts towards people and its surroundings. Strong institutional value in economy gives courage and motivation for its internal society to stand independent econimically. The concept of independence  and economic empowerement in pesantren has surely lacknesses because of non-competent Human Resource in its field. However, sustainable evaluation and improvement can be an example of how non-economic organization can empower itself and empowering its surrounding
Pengaruh Gaya Hidup dan Tingkat Pendapatan terhadap Perilaku Konsumsi Islami pada New Normal (Studi Kasus Masyarakat Muslim Usia Produktif di Surabaya)
Authors: Fajirin Fauzan Bahamarianto , Indrarini Rachma
Published: March 2022

In the teachings of Islam, consumption behavior is based on the Al-Quran and Hadith where in consumption, satisfaction is not number one, but maslahah (benefit) must be prioritized in carrying out consumption activities. Many factors can influence Islamic consumption behavior, one of which is lifestyle and income level. Situations and conditions during the "new normal" period can also influence changes in Islamic consumption behavior. The purpose of this research is to see the effect of lifestyle and income levels on Islamic consumption behavior in the new normal. This study uses a quantitative descriptive approach with multiple linear regression data analysis techniques. The results of this study are lifestyle and income levels have a positive effect simultaneously or partially on Islamic consumption behavior in the new normal period.
PENERAPAN METODE COLLABORATIVE LEARNING BERBANTUAN MEDIA GAMBAR UNTUK MENINGKATKAN MOTIVASI BELAJAR BAHASA JEPANG
Authors: Mayasari Erma Dewi
Published: March 2022

This type of research is classroom action research. This research was conducted on the grounds of improving the learning methods used by teachers. To improve students motivation to learn japanese in this study using 3 cycles. In each cycle have the applicatition of the same action. The result obtained in each cycle showed a positive increase in student motivation. The Final results obtained until the third cycle, each indicator increased between 5-10%. As in the indicator of being diligent in facing tasks, it increased by 5% from previous cycle. The indicator of interest in learning japanese also increased by 4% from previous cycle. And indicator of working with groups 2hen learning japanese increased 9% previously. Based onthe results obtained, it was decided that this study was terminated because the final result in cycle III had an average of 87,5%. This percentage value has fulfilled the requirements for the success indicator, namely 76%. So a study that focused on increasing students motivation to learn Japanese was decided to stop. Therefore, for the next research in addition to learning motivation, student learning outcomes should also be measured. Currently, classroom action research that has been carried out by researchers in using the collaborative larning method has succeeded in increasing students motivation to learn Japanese.
INTERFERENSI DAN INTEGRASI BAHASA
Authors: Firmansyah Muhammad Arif
Published: March 2022

Dalam masyarakat bilingual, lazim terjadi fenomena kebahasaan berupa interferensi dan integrasi. Kedua fenomena kebahasaan ini muncul karena terjadinya kontak dua bahasa yakni bahasa pertama dan bahasa kedua. Saling kontak tersebut bisa berdampak merugikan atau menguntungkan. Jika kontak bahasa terjadi dan unsur bahasa pertama atau kedua yang digunakan oleh penutur bahasa bilingual ternyata berbeda, hal ini disebut sebagai interferensi dan mengakibatkan kesalahan berbahasa. Sebaliknya, jika kontak bahasa yang terjadi dan itu berarti terjadi peristiwa peminjaman atau penyerapan unsur-usur bahasa pertama ke bahasa kedua atau sebaliknya dan ternyata berdampak positif, yaitu memerkaya bahasa pertama atau kedua, fenomena ini disebut sebagai integrasi. Keduanya merupakan salah satu bahasan dalam kajian sosiolinguistik.Tujuan tulisan ini adalah membahas interferensi dan intergrasi bahasa pertama dan bahasa kedua dalam kajian sosiolinguistik.