bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating System Perspectives to Optimize Ecosystem Service Provision in Urban Ecological Development
Authors: Cai Wenbo , Shu Chengji
Published: September 2024

System-based approaches are critical for addressing the complex and interconnected nature of urban ecological development and restoration of ecosystem services. This study adopts a system perspective to investigate the spatiotemporal drivers of key ecosystem services, including carbon sequestration, water conservation, sediment reduction, pollution mitigation, and stormwater regulation, within the Yangtze River Delta Eco-Green Integrated Development Demonstration Area (YRDDA) from 2000 to 2020. We propose a novel framework for defining enhanced-efficiency ecosystem service management regions (EESMR) to guide targeted restoration. Our analysis revealed the complex interplay of 11, 9, 6, 6, and 10 driving factors for selected ecosystem services, highlighting the spatiotemporal heterogeneity of these drivers. By overlaying these key factors, we identified high-efficiency restoration priority areas for EESMR that ensure high returns on investment and the efficient restoration of ecosystem functions. This system-oriented approach provided critical spatial guidance for integrated ecological restoration, green development, and eco-planning. These findings offer valuable insights for policymakers and planners in the Yangtze River Delta and other rapidly urbanizing regions, supporting the formulation of effective land-use policies that balance environmental sustainability and urban growth.
Tuning VSV-G Expression Improves Baculovirus Integrity, Stability and Mammalian Cell Transduction Efficiency
Authors: Mattioli Martina , Raele Renata A. , Gautam Gunjan , Borucu Ufuk , Schaffitzel Christiane , Aulicino Francesco , Berger Imre
Published: September 2024

Baculoviral vectors (BVs) derived from Autographa californica multiple nucleopolyhedrovirus (AcMNPV) are an attractive tool for multigene delivery in mammalian cells, which is particularly relevant for CRISPR technologies. Most applications in mammalian cells rely on BVs that are pseudotyped with vesicular stomatitis virus G-protein (VSV-G) to promote efficient endosomal release. VSV-G expression typically occurs under the control of the hyperactive polH promoter. In this study, we demonstrate that polH-driven VSV-G expression results in BVs characterised by reduced stability, impaired morphology, and VSV-G induced toxicity at high multiplicities of transduction (MOTs) in target mammalian cells. To overcome these drawbacks, we explored five alternative viral promoters with the aim of optimising VSV-G levels displayed on the pseudotyped BVs. We report that Orf-13 and Orf-81 promoters reduce VSV-G expression to less than 5% of polH, rescuing BV morphology and stability. In a panel of human cell lines, we elucidate that BVs with reduced VSV-G support efficient gene delivery and CRISPR-mediated gene editing, at levels comparable to those obtained previously with polH VSV-G-pseudotyped BVs (polH VSV-G BV). These results demonstrate that VSV-G hyperexpression is not required for efficient transduction of mammalian cells. By contrast, reduced VSV-G expression confers similar transduction dynamics while substantially improving BV integrity, structure, and stability.
Toward the Eradication of Herpes Simplex Virus: Vaccination and Beyond
Authors: Chang Jane Y. , Balch Curt , Oh Hyung Suk
Published: September 2024

Herpes simplex virus (HSV) has coevolved with Homo sapiens for over 100,000 years, maintaining a tenacious presence by establishing lifelong, incurable infections in over half the human population. As of 2024, an effective prophylactic or therapeutic vaccine for HSV remains elusive. In this review, we independently screened PubMed, EMBASE, Medline, and Google Scholar for clinically relevant articles on HSV vaccines. We identified 12 vaccines from our literature review and found promising candidates across various classes, including subunit vaccines, live vaccines, DNA vaccines, and mRNA vaccines. Notably, several vaccines—SL-V20, HF10, VC2, and mRNA-1608—have shown promising preclinical results, suggesting that an effective HSV vaccine may be within reach. Additionally, several other vaccines such as GEN-003 (a subunit vaccine from Genocea), HerpV (a subunit vaccine from Agenus), 0ΔNLS/RVx201 (a live-attenuated replication-competent vaccine from Rational Vaccines), HSV 529 (a replication-defective vaccine from Sanofi Pasteur), and COR-1 (a DNA-based vaccine from Anteris Technologies) have demonstrated potential in clinical trials. However, GEN-003 and HerpV have not advanced further despite promising results. Continued progress with these candidates brings us closer to a significant breakthrough in preventing and treating HSV infections.
Identification and Characterization of Novel Serpentoviruses in Viperid and Elapid Snakes
Authors: Tillis Steven B. , Chaney Sarah B. , Crouch Esther E. V. , Boyer Donal , Torregrosa Kevin , Shuter Avishai D. , Armendaris Anibal , Childress April L. , McAloose Denise , Paré Jean A. , Ossiboff Robert J. , Conley Kenneth J.
Published: September 2024

Viruses in the subfamily Serpentovirinae (order Nidovirales, family Tobaniviridae) can cause significant morbidity and mortality in captive snakes, but documented infections have been limited to snakes of the Boidae, Colubridae, Homalopsidae, and Pythonidae families. Infections can either be subclinical or associated with oral and/or respiratory disease. Beginning in June 2019, a population of over 150 confiscated snakes was screened for serpentovirus as part of a quarantine disease investigation. Antemortem oropharyngeal swabs or lung tissue collected postmortem were screened for serpentovirus by PCR, and 92/165 (56.0%) of snakes tested were positive for serpentovirus. Serpentoviruses were detected in fourteen species of Viperidae native to Asia, Africa, and South America and a single species of Elapidae native to Australia. When present, clinical signs included thin body condition, abnormal behavior or breathing, stomatitis, and/or mortality. Postmortem findings included variably severe inflammation, necrosis, and/or epithelial proliferation throughout the respiratory and upper gastrointestinal tracts. Genetic characterization of the detected serpentoviruses identified four unique viral clades phylogenetically distinct from recognized serpentovirus genera. Pairwise uncorrected distance analysis supported the phylogenetic analysis and indicated that the viper serpentoviruses likely represent the first members of a novel genus in the subfamily Serpentovirinae. The reported findings represent the first documentation of serpentoviruses in venomous snakes (Viperidae and Elapidae), greatly expanding the susceptible host range for these viruses and highlighting the importance of serpentovirus screening in all captive snake populations.
Insights into the Role of VPS39 and Its Interaction with CP204L and A137R in ASFV Infection
Authors: Dolata Katarzyna Magdalena , Karger Axel
Published: September 2024

The African swine fever virus (ASFV) is a large and complex DNA virus that causes a highly lethal disease in swine, for which no antiviral drugs or vaccines are currently available. Studying viral–host protein–protein interactions advances our understanding of the molecular mechanisms underlying viral replication and pathogenesis and can facilitate the discovery of antiviral therapeutics. In this study, we employed affinity tagging and purification mass spectrometry to characterize the interactome of VPS39, an important cellular factor during the early phase of ASFV replication. The interaction network of VPS39 revealed associations with mitochondrial proteins involved in membrane contact sites formation and cellular respiration. We show that the ASFV proteins CP204L and A137R target VPS39 by interacting with its clathrin heavy-chain functional domain. Furthermore, we elaborate on the potential mechanisms by which VPS39 may contribute to ASFV replication and prioritize interactions for further investigation into mitochondrial protein function in the context of ASFV infection.
Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Studies
Authors: Khalifa Mahmoud E. , Ayllón María A. , Rodriguez Coy Lorena , Plummer Kim M. , Gendall Anthony R. , Chooi Kar Mun , van Kan Jan A.L. , MacDiarmid Robin M.
Published: September 2024

Mycoviruses are highly genetically diverse and can significantly change their fungal host’s phenotype, yet they are generally under-described in genotypic and biological studies. We propose Botrytis cinerea as a model mycovirus system in which to develop a deeper understanding of mycovirus epidemiology including diversity, impact, and the associated cellular biology of the host and virus interaction. Over 100 mycoviruses have been described in this fungal host. B. cinerea is an ideal model fungus for mycovirology as it has highly tractable characteristics—it is easy to culture, has a worldwide distribution, infects a wide range of host plants, can be transformed and gene-edited, and has an existing depth of biological resources including annotated genomes, transcriptomes, and isolates with gene knockouts. Focusing on a model system for mycoviruses will enable the research community to address deep research questions that cannot be answered in a non-systematic manner. Since B. cinerea is a major plant pathogen, new insights may have immediate utility as well as creating new knowledge that complements and extends the knowledge of mycovirus interactions in other fungi, alone or with their respective plant hosts. In this review, we set out some of the critical steps required to develop B. cinerea as a model mycovirus system and how this may be used in the future.
New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs
Authors: Marra Maria , Catalano Alessia , Sinicropi Maria Stefania , Ceramella Jessica , Iacopetta Domenico , Salpini Romina , Svicher Valentina , Marsico Stefania , Aquaro Stefano , Pellegrino Michele
Published: September 2024

More than 80 million people worldwide have been infected with the human immunodeficiency virus (HIV). There are now approximately 39 million individuals living with HIV/acquired immunodeficiency syndrome (AIDS). Although treatments against HIV infection are available, AIDS remains a serious disease. Combination antiretroviral therapy (cART), also known as highly active antiretroviral therapy (HAART), consists of treatment with a combination of several antiretroviral drugs that block multiple stages in the virus replication cycle. However, the increasing usage of cART is inevitably associated with the emergence of HIV drug resistance. In addition, the development of persistent cellular reservoirs of latent HIV is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Thus, several efforts are being applied to new generations of drugs, vaccines and new types of cART. In this review, we summarize the antiviral therapies used for the treatment of HIV/AIDS, both as individual agents and as combination therapies, and highlight the role of both macrophages and HIV cellular reservoirs and the most recent clinical studies related to this disease.
Research on Water Content Spatial Distribution Pattern of Fine—Grained Sediments in Debris Flow—Taking Beichuan Debris Flow as a Case
Authors: Wang Qinjun , Xie Jingjing , Yang Jingyi , Liu Peng , Xu Wentao , Yuan Boqi , He Chaokang
Published: September 2024

Due to being lightweight, fine-grained sediments easily flow with water and thus amplify the destructive effect of debris flow hazards. In such hazards, water content and shear strength are key inter-controlled factors relating to the stability of fine-grained sediments and thus control the density, scale, and danger of debris flow hazards. Although the correlation between water content and sediment stability has been studied, there are still some issues to be solved: what is the changing trend of shear strength with increasing water content? What is the water content spatial distribution pattern of fine-grained sediments in debris flow? What is the role/impact of this pattern on debris flow hazards prevention? Therefore, the objective of this research is to show the spatial distribution pattern of water content and establish a correlation between the water content and the shear strength of fine-grained sediments to provide a scientific basis for debris flow hazard prevention. Taking the Beichuan debris flow for our study, with a length of 37.6 km, and a 341 km2 study area, the results show that (1) the average water content shows an increasing trend, from 9.9% in the upstream of the river (SP01–SP05) to 21.7% in the downstream of the river (SP13–SP15). (2) When unsaturated, the correlation between the water content and shear strength is determined by combining the cohesion, normal stress, and internal friction angle; when saturated, the water content is negatively correlated with shear strength. (3) Water content and shear strength are the key inter-controlled factors relating to the stability of fine-grained sediments, and the water content distribution pattern of this research indicates the key locations that require attention: locations with high water content in the downstream river or with high curvature, which is of some significance for debris flow hazard prevention.
What Is Relatively Permanent? Flow Regimes of Arizona Streams within the Context of the 2023 Conforming Rule on the Revised Definition of “Waters of the United States”
Authors: Julian Jason P. , Stuhldreher Courtney , Wade Madeline T.
Published: September 2024

The classification of stream flow regimes has been a subject of study for over a half century in the fields of hydrology, geomorphology, ecology, and water resources management. But with the most recent Supreme Court decision on jurisdictional Waters of the United States (WOTUS) and the 2023 Conforming Rule, the answer to the question of which waters are relatively permanent has increased in importance and urgency. One state where this question is salient is Arizona, where approximately 95% of its streams are nonperennial. In this study, we use long-term (>30 years) daily discharge records from Arizona to assess semi-natural flow regimes of arid streams within the context of the 2023 Conforming Rule. Using flow percentile distributions, we distinguished flow permanency—ephemeral vs. intermittent vs. perennial—for 70 stream reaches distributed throughout the state. Ephemeral streams had a median flow of 0 cms and a 75th percentile flow permanence less than 25% (i.e., less than 3 months of flow for every 7.5 out of 10 years). On the other end of the spectrum, perennial streams had a 90th percentile flow permanence of 100%. In the middle, intermittent streams had a 75th percentile flow permanence greater than 25% and a 90th percentile flow permanence less than 100%. We also assessed the effect of the recent megadrought (since 1994) on flow permanency. As a result of the megadrought, four perennial streams transitioned to intermittent, four intermittent streams transitioned to ephemeral, and one perennial stream became ephemeral. The flow classification we present here is specific to Arizona streams but could be useful to other arid regions seeking to answer the question of which streams are relatively permanent in a typical year.
Ensuring the Safety of an Extraction Well from an Upgradient Point Source of Pollution in a Computationally Constrained Setting
Authors: Nenninger Christopher , Mihelcic James R. , Cunningham Jeffrey A.
Published: September 2024

Shallow groundwater is an important resource, especially in low- and middle-income countries; however, shallow groundwater is particularly vulnerable to point sources of pollution such as latrines or unlined waste disposal ponds. The objective of this paper is to derive a quantitative criterion for siting an extraction well and an upgradient point source of pollution to ensure that they are hydraulically disconnected, i.e., that no water flows from the point source to the well. To achieve this objective, we modeled the flow of shallow groundwater considering uniform regional flow, a single point source of pollution, and a single extraction well. For any set of flow rates and upgradient point source distance, we sought the minimum “off-center distance” ymin (i.e., the distance in the direction perpendicular to regional flow) that ensures the well and the point source are hydraulically disconnected. For constituencies with access to computing resources and coding expertise, we used a computer-based method for determining ymin that is exact to within the accuracy of a root-finding algorithm; this approach is recommended when computer access is available. For constituencies lacking these resources, we determined a simple, closed-form, approximate solution for ymin that has an average error of less than 3% for the conditions we tested. For a subset of scenarios in which the point source is sufficiently far upgradient of the well (n = 77), the root mean square relative error of the approximate solution is only 0.52%. We found that ymin depends on a length parameter (Qw + Qps)/QR, where Qw is the extraction rate of the well, Qps is the injection rate of the point source, and QR is the regional groundwater flow rate per unit of perpendicular length. Either the exact solution or the closed-form approximation can help to site wells near point sources of pollution, or to site point sources near wells, in a manner that protects the health of the well user. The approximate solution is valuable because many constituencies that rely on shallow wells for water supply and latrines for sanitation also lack access to the computer resources necessary to apply the exact solution.
A Comprehensive Evaluation of Water Resource Carrying Capacity Based on the Optimized Projection Pursuit Regression Model: A Case Study from China
Authors: Su Yuelong , Xu Xiangdong , Dai Meng , Hu Yan , Li Qianna , Shu Shumiao
Published: September 2024

The Han River Ecological Economic Belt (HREEB) has a substantial amount of water resources; however, its distribution is uneven, and issues such as seasonal and engineering water shortages are prevalent. This necessitates a thorough assessment of the current water resource situation and trends in water resource carrying capacity (WRCC) to provide scientific support for the rational allocation of water resources. This study employed the RAGA-PP model to establish a WRCC evaluation index system composed of four subsystems: water resources, economy, society, and the ecological environment. The WRCC of the 17 major cities in the HREEB was evaluated from 2008 to 2022. The differentiation method was introduced to compare the reliability of the RAGA-PP model with three evaluation methods: the entropy weight TOPSIS method, the rank sum ratio method, and the principal component analysis method. In addition, an obstacle degree model was introduced to analyze the factors influencing WRCC enhancement. The results indicated the following. (1) In the differentiation test of the four models, the RAGA-PP model was found to have the highest differentiation value, and the results showed that it was more reliable in the WRCC evaluation of HREEB. (2) WRCC in the HREEB underwent significant changes between 2008 and 2022. (3) The WRCC in Shiyan and Wuhan, which are located in the eastern part of the HREEB, were high in Hubei, low in four cities in Henan, and satisfactory in three cities in Shaanxi. (4) The carrying capacity of the subsystems of the cities in the HREEB exhibited fluctuating changes with obvious internal variations. (5) The problems in the WRCC guideline layer were consistent across all cities in the HREEB, with limited per capita water resources being the primary issue in the indicator layer. Assessing WRCC is essential for achieving sustainable water resource use and high-quality regional development.
Application of Hydrogeophysical Techniques in Delineating Aquifers to Enhancing Recharge Potential Areas in Groundwater-Dependent Systems, Northern Cape, South Africa
Authors: Baloyi Lucky , Kanyerere Thokozani , Muchingami Innocent , Pienaar Harrison
Published: September 2024

The application of hydrogeophysical techniques to delineating aquifers was conducted in De Aar, the eastern part of the Karoo region, Northern Cape, South Africa. Previously, recharge estimations in this region assumed a uniform aquifer type, overlooking the presence of diverse aquifer systems. This study identified both unconfined and confined aquifers to improve recharge potential assessments. Vertical electrical resistivity sounding (VES) and ground telluric methods were applied. Six VES stations and eleven profiles were measured using a 1D Wenner array configuration. The VES data, processed with IPI2win software, generated a 2D subsurface model. In contrast, the telluric data were analyzed using an automated algorithm to create a 2D profile. The electric potential difference curve was interpreted in comparison with lithological cross-sections. The VES results revealed three to four distinct layers of low-resistivity (0.9–8.1 Ωm), moderate-resistivity (22.4–125 Ωm), and high-resistivity (68–177 Ωm) values, indicating three lithological formations. The telluric data suggested that shallow groundwater boreholes were located in areas with groundwater levels above 50 m. These findings, which matched the lithological data, pointed to a double-layer aquifer system, suggesting that recharge estimates should be carried out to different aquifer layers. The study demonstrated how hydrogeophysical methods can effectively delineate aquifer systems and enhance the identification of recharge areas.
Life-Cycle Analysis of Natural Treatment Systems for Wastewater (NTSW) Applied to Municipal Effluents
Authors: Chirinza Nicolau , Zerpa Federico A. Leon , Muguirrima Paulino , del Pino García Tania , Rodriguez Gilberto Martel , Gutierrez Camila , Pino Carlos A. Mendieta
Published: September 2024

The objective of the described activity is to develop technologies or proposals that can be implemented within the cycle to enhance the relationship between climate change, water, energy, and food. The focus is on analyzing natural treatment systems for wastewater (NTSW) within the context of Macaronesia, considering factors such as life-cycle assessment (LCA), carbon footprint, impacts, and mitigation capacity. The analysis of real case data from the Canary Islands and Cape Verde will inform the development of appropriate technologies tailored to different areas and scales within Macaronesia. This work includes a comprehensive life-cycle analysis of the Santa Catarina (Cape Verde) NTSW. This analysis encompasses: (a) Inventory analysis of the construction phase: This involves the assessment of inputs and outputs associated with the construction of the NTSW, including materials, energy consumption, transportation, and waste generation. The maintenance and operation phases are then evaluated, with a focus on the ongoing maintenance and operation activities required for the NTSW, including energy consumption, water usage, chemical inputs (if any), labor, and equipment maintenance. (b) Finally, the impacts of the NTSW are evaluated. The environmental, social, and economic impacts generated by the NTSW are assessed. This includes an analysis of factors such as carbon emissions, water usage, land use, ecosystem impacts, human health effects, and economic costs. By conducting a comprehensive analysis of the Santa Catarina NTSW, the document aims to provide insights into the environmental performance and sustainability of the system. This information can then be used as a tool and experience of educational innovation for final-year undergraduate students to identify areas for improvement, develop mitigation strategies in the water sector, and inform decision-making processes regarding wastewater treatment technologies in Macaronesia. Furthermore, lessons learned from real case studies in the Canary Islands and Cape Verde can be applied to similar regions within the Macaronesia archipelago (IDIWATER project).
Tendencias actuales del marketing digital: Revisión sistemática
Authors: Ordoñez Gavilanes Magdalena Emilia , Aguayza Mainato Luz Patricia
Published: September 2024

El marketing digital permite a las organizaciones alcanzar una audiencia global de manera eficiente, medir el impacto de sus campañas en tiempo real y personalizar la experiencia del cliente. El estudio pretendió analizar desde la revisión sistemática las tendencias actuales en la gestión del marketing digital y su aplicación en el ámbito empresarial, en publicaciones científicas entre los años 2018 y 2024. La investigación fue realizada aplicando el método PRISMA, iniciado con la búsqueda de artículos científicos en bases de datos como Scopus, Web of Science y Ebsco, entre otras, seleccionando bajo los criterios del método 34 publicaciones que se analizaron utilizando una matriz de registro. Los resultados identifican que el Big Data y la Inteligencia Artificial, impulsan la aplicación del marketing digital y su desarrollo, en beneficio de las organizaciones que optimizan sus procesos de interacción con el cliente, gestión de mercadeo, incrementando la cartera de clientes y brindando mayor satisfacción de sus necesidades y deseos.
MIGRATION POLICY IN RUSSIA: PLACE AND ROLE OF VISA LABOR MIGRATION TODAY
Authors:   Primakov Institute of World Economy and International Relations, Russian Academy of Sciences, Moscow, Russia, Komarovsky V.V.
Published: September 2024

The subject of the study is the place and role of visa labor migration in modern Russian migration policy. The purpose of the paper is to analyze the current state of visa labor migration in the context of federal districts and specific regions, meeting their needs for skilled labor. The relevance of the study is due to the emerging trend of increasing annual volumes of quota migration, the prospects for the development of these trends, and the analysis of the role of the main countries supplying labor migrants. The research methods include analysis, systematization, synthesis, and classification of the objects under study. In the course of the study, an attempt was made to classify the country’s regions by the scale of visa labor migration and to assess the impact of regional imbalances on its development and the stability of the quota system. A conclusion was made about the high degree of sustainability of the existing migration flows from a number of countries. The practical results of the study are determined by the possibility of using the obtained data to forecast and plan the scale and structure of attracting visa-based foreign labor to Russia.
REMUNERATION AND INCENTIVES TO IMPROVE PERFORMANCE OF CIVIL SERVANTS
Authors:   All-Russian Research Institute of Labor, Moscow, Russia, Vashalomidze E.V.
Published: September 2024

The study is devoted to the assessment and analysis of the current system of remuneration and incentives for civil servants in Russia. The purpose of the paper is to develop solutions designed to determine the scientific principles and main directions for improving the system of remuneration and incentives for civil servants in the long term. The empirical basis of the study is the statistical data of Rosstat, the Ministry of Finance of the Russian Federation, and specialized scientific literature. The study uses the methods of critical analysis of the state and problems of incentives for civil servants, comparative and statistical analysis, abstraction, and modeling of socio-economic phenomena. As a result of the analytical work, systemic and structural problems in the mechanisms of remuneration of civil servants, shortcomings associated with the insufficient transparency of establishing the amounts and forms of remuneration and incentives, as well as justification for the differentiation of official salaries and allowances were identified. It is noted that financial incentives for civil servants in Russia do not fully meet the rational requirements for accounting for labor productivity, especially in the context of existing and developing digital competencies. There are imbalances in non-financial incentives, including a reduction in the social package. To solve the identified problems and eliminate the existing contradictions, specific measures are proposed aimed at increasing transparency and actively using digital tools in the field of planning and improving technologies for remuneration and incentives for civil servants, developing new, more effective methods of non-material incentives, and establishing additional bonus payments for the development of digital competencies. The author concludes that the system of remuneration and incentives for the Russian civil servants, taking into account their actual performance, regulated by bonus payment, allowances and a certain social package, and opportunities for career growth, with the realization of aspirations to honestly and conscientiously serve their homeland, should be developed in a timely and effective manner, taking into account the proposed approaches.
Otoimmün Hastalıklarda Probiyotikler Bir Tedavi Yöntemi Olabilir mi?
Authors: Şeker Elif , Özdemir Öner
Published: September 2024

Probiyotikler, günümüzde gastrointestinal enfeksiyonlar başta olmak üzere, ürogenital ve periodontal enfeksiyonların tedavi ve profilaksisinde sıklıkla kullanılmaktadır. Gastrointestinal sistemin mikrobiyatanın en çok olduğu bölgedir. Diyet, toksinler, ilaçlar, patojenler ve çeşitli çevresel faktörler tarafından mikrobiyota değişikliğe uğrayabilir. Mikrobiyom içeriğinin değişmesi barsak bariyerinin bozulmasına ve kronik inflamatuar hastalık ve otoimmün hastalıkların gelişmesine yol açabilir. Probiyotiklerin bağışıklık mekanizmalarını da düzenlediği bilinmektedir. Konak ve mikrobiyata arasındaki ilişki hastalıkların immünopatolojik açıdan değerlendirilmesine olanak sağlamıştır. Bağışıklık dengesini korumak ve geri kazanmak için probiyotiklerin etkisi birçok çalışmanın odak noktası olmuştur. Burada mikrobiyomun otoimmün hastalıklardaki rolünü ve probiyotik kullanımının otoimmün hastalıklara etkisinden bahsedeceğiz.
Violência doméstica: medidas adotadas na Polícia Militar do Paraná
Authors: Sartor Indianara
Published: September 2024

A violência contra a mulher é um grave problema social com proporções mundiais, a qual ganha cada vez mais destaque devido a sua magnitude. Traz prejuízos para a construção de uma sociedade mais justa e igualitária,  não se restringindo somente à violência física, mas também à violência moral, psíquica e patrimonial. Como ferramenta para proteção dos direitos e integridade da mulher, foi criado em 2006, a Lei Maria da Penha, e neste contexto é fundamental o papel da Polícia Militar, enquanto órgão que está “na linha da frente” no auxilio ao cumprimento da lei, atuando não somente de forma repressiva, mas preventivamente a fim de coibir e minimizar a violência contra às mulheres, através de, por exemplo, visitas contínuas às vítimas de violência doméstica e familiar. Neste contexto destaca-se a criação das Patrulhas Maria da Penha na Polícia Militar do Paraná, com equipes policiais especializadas para atendimento às vitimas de violência doméstica, com visitas, encaminhamentos e orientações direto às vitimas, palestras para a público geral sobre o tema, e ainda suporte ao judiciário quanto a efetivação das medidas protetivas de urgência. Assim, o presente estudo tem como finalidade expor a problemática do tema, através de análises documentais e dados quantitativos, e apresentar as medidas e ferramentas que estão sendo executadas, não somente a nível de Estado, mas as medidas adotadas na Polícia Militar do Paraná.
Avaliação do uso de cetamina em bolus intravenoso no atendimento de emergências pediátricas
Authors: Marafante Maria Eduarda Osório , Schiattarella Millan Christinne da Silva , Azevedo Renata Cristina Santos de , Nepomuceno Tiago Leal , Reis Marcelo Arteiro Costa , Soares Luiz Eduardo Vilar , Araújo Ingrid Katherine Bezerra de , Pinheiro Kamylle Ferreira , Faria Ivan Aurélio Fortuna Kalil de , Faria Anna Beatriz Inácio Fortuna Kalil de , Netto Hilário Gurgel da Cunha , Álvares Júlia Porcino Reinaldo Marinho , Costa Gabriela de Macedo , Gonçalves Luzia Valberligia Batista , Lemos Eduarda Campos , Rocha Rafael de Luna , Costa Lívia Albuquerque , Artmann Sueli Adriana Ferreira Teixeira , Loverbeck Vitoria Robattom , Pontes Pedro Henrique Fonseca , Melo Matheus de Alencar Lira , Braga Bruno de Vasconcelos , Andrade Filho Áureo Pedro Silva de , Gomes João Vitor Ferraz , Melo Luis Eduardo Barros de
Published: September 2024

Devido ao aumento do uso de cetamina intravenosa em situações de emergência pediátrica, principalmente para sedação, alívio da dor e tratamento de condições graves como traumatismo craniano e ideação suicida, é imprescindível avaliar de forma crítica sua eficácia e segurança nessas situações. O presente estudo visa examinar e analisar de maneira sistemática diversos estudos que investigaram a administração intravenosa de cetamina em situações de emergência pediátrica, com foco em seus resultados clínicos, perfil de segurança e eficácia global. Os resultados obtidos indicam que a cetamina intravenosa é eficaz para proporcionar sedação e alívio da dor rapidamente, com um perfil de segurança favorável quando administrada por profissionais de saúde capacitados. Foi observado que a cetamina reduz de forma significativa a intensidade da dor, diminui a ideação suicida e controla de maneira eficaz a pressão intracraniana em crianças com traumatismo craniano grave. No entanto, a revisão também destacou a variação nos tempos de recuperação e a ocorrência de efeitos colaterais leves a moderados, como tontura, náusea e sonolência. Além disso, a necessidade de doses adicionais foi mais comum na administração intravenosa em comparação com a via intramuscular, apesar de oferecer um início de ação mais rápido e uma duração mais curta. Concluímos que, embora a cetamina intravenosa seja uma ferramenta valiosa em situações de emergência pediátrica, sua administração deve ser monitorada com cuidado, especialmente em pacientes de alto risco, a fim de minimizar os possíveis efeitos adversos. São necessárias mais pesquisas para aprimorar as estratégias de dosagem, investigar os desfechos a longo prazo e estabelecer protocolos padronizados para maximizar os benefícios terapêuticos da cetamina e reduzir os riscos.
Análise epidemiológica da morbidade hospitalar devido quedas de própria altura da população idosa na cidade de Maringá-PR
Authors: Soares Lilian Capelari , Melo Tércio Ernandes Cruz de , Silva Vítor Montanha da , Thomazetto Matheus Gomes , Magalhães Hortênsia Cândida Félix , Oliveira Matheus Santana Almeida Prado de , Mourad Malek Abdo Abou , Silva João Victor Alves da , Miranda Ana Luísa Tavares de , Silva Lucas Carvalho da
Published: September 2024

O envelhecimento global traz vários desafios para políticas públicas de saúde, com projeções que indicam que até 2050 cerca de 20% da população mundial será composta por idosos. No Brasil, a população idosa já é significativa, podendo alcançar 30% até 2050. Com o crescente número de idosos no Brasil, episódios de queda tornam-se cada vez mais frequentes. Devido a esse fato, o conhecimento dos dados acerca da internação de indivíduos idosos vítimas de quedas tem sua importância para o planejamento de políticas de prevenção, além de mostrar um cenário muitas vezes negligenciado ou desconhecido pela população. Este trabalho trata-se de um estudo transversal, retrospectivo, com abordagem quantitativa acerca do número de internações de idosos na cidade de Maringá-PR devido a quedas, analisando também a mortalidade dos episódios. Os dados foram obtidos através do sistema DATASUS.  Os dados obtidos mostram 205 internações do total, sendo a maioria delas (79) na população com mais de 80 anos.  Cabe destacar que a população feminina sofre mais com internações devido a quedas de própria altura do que a população masculina, 151 contra 54 respectivamente. Porém, quando analisado a taxa de mortalidade, a população masculina possui números maiores que a população feminina. A cidade de Maringá segue com a mesma tendência de estudos mais robustos tanto envolvendo o Brasil quanto outros países. Apesar da baixa taxa de mortalidade, o quadro de quedas nessa população está atrelado à condições que podem desencadear vários outros problemas de saúde, impedindo esse indíviduo de envelhecer com qualidade de vida.
Influência dos desreguladores endócrinos no desenvolvimento puberal: uma revisão integrativa
Authors: Mendonça Kamylly Reina Carneiro de , André Luiz Cardoso  , Silva Rayana Queiroz da
Published: September 2024

Considerando a crescente preocupação com os desreguladores endócrinos (DEs) e seus impactos na saúde humana, especialmente no desenvolvimento puberal, este estudo visa investigar a relação entre a exposição a DEs e a ocorrência de puberdade precoce. Objetiva-se analisar os mecanismos pelos quais os DEs influenciam o sistema endócrino e identificar as substâncias mais comuns envolvidas. Para tanto, procede-se à uma revisão integrativa da literatura, seguindo seis etapas recomendadas, incluindo a seleção de artigos relevantes publicados nos últimos cinco anos. Desse modo, observa-se que a exposição a DEs, como bisfenóis e ftalatos, está associada a alterações no desenvolvimento puberal, com evidências de impactos significativos na saúde reprodutiva e metabólica das crianças, permitindo concluir que é essencial adotar medidas preventivas para minimizar a exposição a esses compostos, promovendo práticas de consumo e estilo de vida mais seguras, além de regulamentações mais rigorosas sobre o uso de substâncias químicas potencialmente perigosas.
Alopecia androgenética feminina: do diagnóstico ao tratamento
Authors: Coelho Maria Paula Borsari
Published: September 2024

A alopecia androgenética feminina ou alopecia de padrão feminino (APF) é a forma mais comum de queda de cabelo nas mulheres, possuindo alta prevalência e infligindo grande impacto na qualidade de vida feminina. O presente estudo busca analisar a APF de modo a abordar seu diagnóstico, epidemiologia, fisiopatologia e tratamentos. Para tanto, realizou-se uma revisão bibliográfica baseada em 16 artigos científicos selecionados por sua relevância e qualidade metodológica. Observa-se, dessa forma, que apesar de várias pesquisas realizadas visando o entendimento da etiologia da doença, a atuação hormonal sobre o corpo feminino não foi ainda totalmente compreendida. Assim, a complexidade da APF exige uma contínua evolução de pesquisas e desenvolvimento de novas terapêuticas no futuro.
Obstrucción intestinal en el paciente oncológico, revisión de tema
Authors: Coello Guido Arturo Panchana , León Erick Alexander Jara , Francisco Llerena Freire Luis , Chico Tatiana Michelle Ron , Arévalo Leonardo Nicolay Vinueza , Ramos Gabriel Matías Alcivar , Casquete Dumar Esteban Mera , Diez Walter Andrés Cercado
Published: September 2024

La obstrucción intestinal maligna es una condición compleja que, a pesar de su baja frecuencia, causa un gran malestar debido a los síntomas derivados de alteraciones mecánicas y funcionales en los mecanismos fisiopatológicos. Entre estos mecanismos se incluyen la obstrucción del lumen intestinal, las alteraciones en la motilidad y la acumulación de secreciones. El tratamiento de esta condición debe ser personalizado para cada paciente, considerando ya sea una intervención quirúrgica o un tratamiento médico. En general, se recomienda emplear una estrategia que combine de manera sinérgica diversas opciones para lograr un control óptimo de los síntomas.
ANALISIS PENERAPAN SOCIAL MEDIA MARKETING INSTAGRAM PADA HOTEL HORISON PALMA PANGANDARAN MENGGUNAKAN FRAMEWORK DRAGONS
Authors: Firmansyah Nur Iman , Chan Arianis , Dai Raden Ratna Meisa
Published: September 2024

Hotel Horison Palma Pangandaran is a company engaged in the hotel industry. This research aims to obtain information and a real picture of how to implement  the Instagram social media marketing strategy at the Horison Palma Pangandaran Hotel. The research method used is qualitative descriptive which explains descriptively how to implement  the Instagram social media marketing strategy  carried out by Hotel Horison Palma Pangandaran. The data collection technique of this study is through interviews with 6 informants, documentation and literature studies, source triangulation, and using the DRAGONS framework analysis. The results of this study show that the company in implementing the dimensions  of content creation, content sharing, and community building has been running well. Meanwhile,  the connecting dimension  still experiences several obstacles that can be repaired and maximized by the Horison Palma Pangandaran Hotel.
IMPLEMENTASI KONTEN MARKETING SOSIAL MEDIA INSTAGRAM PMJ UNIFORM TAHUN 2024
Authors: Muhammad Miftahul Huda  , Widya Sastika
Published: September 2024

Fashion has always been a necessity for everyone from babies to adults. Every Indonesian knows what they wear every day. Globally, fashion means a popular style in a particular culture to support the appearance of someone who uses it, or it can be interpreted as a unique characteristic for the person who wears it. The purpose of this study was to determine methods for implementing, executing, and evaluating business social media marketing content for PMJ UNIFORM marketing. Data was collected through observations of other uniform competitors on Instagram social media and interviews with internal MSME informants. This research  was conducted  using  descriptive  qualitative  research,  with  object analysis. The results of this study found marketing content needed to increase interaction and knowledge on the @pmjuniform_official Instagram account, when this research was conducted PMJ UNIFORM did not have an Instagram account as a means of promotional media on the internet. With that, the hope of the researcher is also umkm will continue to post interesting and consistent content after this research, because it is very important to maintain and increase insight on Instagram in order to increase sales.
PENGARUH KESADARAN WAJIB PAJAK, SOSIALISASI PERPAJAKAN, DAN PROGRAM PEMUTIHAN PAJAK TERHADAP KEPATUHAN WAJIB PAJAK KENDARAAN BERMOTOR
Authors: Nyale M Hendri Yan , Condrowati Shinta Dewi
Published: September 2024

The regional revenue heavily relies on vehicle taxes, playing a crucial role as one of the main pillars in generating significant income to support local development. Therefore, optimizing state revenue becomes crucial to achieve the government's expected targets. This research aims to examine the effects of taxpayer awareness, tax socialization efforts, and tax amnesty programs on the compliance level of vehicle taxpayers. The population focused on in this study consists of vehicle taxpayers registered at the SAMSAT office in Bogor City. Data collection utilized the simple random sampling method and Slovin's formula to obtain a sample size of 400 respondents. The type of data used is primary data analyzed through the use of a questionnaire with the assistance of SPSS software version 26, and the results were analyzed using a multiple linear regression analysis approach. The findings of this research prove that taxpayer awareness, tax socialization, and tax amnesty programs have a positive impact at a significance level of 5% (X1= 0.266, X2= 0.306, and X3= 0.318).
ANALISIS STRATEGI SOCIAL MEDIA MARKETING DALAM MEMPERTAHANKAN BRAND AWARENESS PADA DOTATO DONAT KAMPUNG (Studi Kasus pada Instagram Dotato)
Authors: Jihan Hanifah Sony  , Cecep Safa’atul Barkah
Published: September 2024

Dotato Donat Kampung, a prominent MSME in the culinary sector, has effectively built substantial brand awareness among students in Jatinangor. However, it faces challenges in sustaining this awareness. This research aims to analyze the social media marketing strategies employed by Dotato Donat Kampung to maintain its brand presence. Utilizing a qualitative approach with a descriptive method, the research involved detailed interviews with both the owners. The effectiveness of the social media marketing strategies was evaluated using the TOWS method. The findings indicate that Dotato Donat Kampung's social media marketing is fairly successful in boosting brand awareness and product sales, although there are certain Instagram features that have not been fully utilized. The analysis highlights the need to optimize the use of Instagram ads and broadcast channels to sustain brand awareness and broaden audience reach.
Dotato Donat Kampung, a prominent MSME in the culinary sector, has effectively built substantial brand awareness among students in Jatinangor. However, it faces challenges in sustaining this awareness. This research aims to analyze the social media marketing strategies employed by Dotato Donat Kampung to maintain its brand presence. Utilizing a qualitative approach with a descriptive method, the research involved detailed interviews with both the owners. The effectiveness of the social media marketing strategies was evaluated using the TOWS method. The findings indicate that Dotato Donat Kampung's social media marketing is fairly successful in boosting brand awareness and product sales, although there are certain Instagram features that have not been fully utilized. The analysis highlights the need to optimize the use of Instagram ads and broadcast channels to sustain brand awareness and broaden audience reach.
The Analysis of Learning Performance Satisfaction for Physical and Online Learning: A Case Study from Taiwan
Authors: Chiu Kuei-Chien , Chen Rung-Ching
Published: September 2024

Management education, continuously evolving since the 1990s, recognizes the need to develop proficient management professional’s adept at strategic decision-making. The present research delves into the effectiveness of a management course for first-year students at a chosen School of Management, underlining its paramount importance in ensuring student retention and bolstering departmental stability. The purpose of this research is to evaluate the effectiveness of traditional physical and online learning methods in a management course for first-year students at a university in Taiwan, focusing on students' satisfaction with their learning performance. The study aims to compare the educational efficacy of these two instructional modes and analyze the variations in student performance and satisfaction. The methodology involved a longitudinal design with data collection from first-year students in 2022 (online learning) and 2023 (physical learning). The research employed pre-test and post-test evaluations, regression analysis, and Importance-Performance Analysis (IPA) to assess the impact of course units on students' learning satisfaction. This study employed regression analysis to determine the influence of enhancing "Management Basis" and "Management Operations" on satisfaction. The results revealed that online learning outperformed physical learning in terms of overall student satisfaction, particularly in understanding "Management Basis" and "Management Operations." However, physical learning demonstrated higher improvements in student scores and satisfaction, particularly in areas requiring detailed explanations and hands-on engagement, such as "Control Tools.". The novelty of this research lies in its comparative approach to evaluating two distinct learning environments during a critical period marked by the COVID-19 pandemic. The findings offer valuable insights into how different teaching modalities impact student satisfaction and learning outcomes, providing guidance for educators to refine instructional strategies to enhance student learning efficacy across different formats. The study underscores the importance of adapting teaching methods to suit the specific demands of online and physical learning environments.