bluuebunny/crossref_metadata_2025 huggingface dataset:
TargetAntiAngio: A Sequence-Based Tool for the Prediction and Analysis of Anti-Angiogenic Peptides
Authors: Laengsri Vishuda , Nantasenamat Chanin , Schaduangrat Nalini , Nuchnoi Pornlada , Prachayasittikul Virapong , Shoombuatong Watshara
Published: June 2019

Cancer remains one of the major causes of death worldwide. Angiogenesis is crucial for the pathogenesis of various human diseases, especially solid tumors. The discovery of anti-angiogenic peptides is a promising therapeutic route for cancer treatment. Thus, reliably identifying anti-angiogenic peptides is extremely important for understanding their biophysical and biochemical properties that serve as the basis for the discovery of new anti-cancer drugs. This study aims to develop an efficient and interpretable computational model called TargetAntiAngio for predicting and characterizing anti-angiogenic peptides. TargetAntiAngio was developed using the random forest classifier in conjunction with various classes of peptide features. It was observed via an independent validation test that TargetAntiAngio can identify anti-angiogenic peptides with an average accuracy of 77.50% on an objective benchmark dataset. Comparisons demonstrated that TargetAntiAngio is superior to other existing methods. In addition, results revealed the following important characteristics of anti-angiogenic peptides: (i) disulfide bond forming Cys residues play an important role for inhibiting blood vessel proliferation; (ii) Cys located at the C-terminal domain can decrease endothelial formatting activity and suppress tumor growth; and (iii) Cyclic disulfide-rich peptides contribute to the inhibition of angiogenesis and cell migration, selectivity and stability. Finally, for the convenience of experimental scientists, the TargetAntiAngio web server was established and made freely available online.
ЭФФЕКТИВНОСТЬ ВНЕДРЕНИЯ СОЧНЫХ КОРМОВ ДЛЯ МОЛОЧНОГО СКОТОВОДСТВА В УСЛОВИЯХ ЦЕНТРАЛЬНОЙ ЯКУТИИ
Authors: PESTEREVA E.S. , PAVLOVA S.A.
Published: June 2019

В целях получения сбалансированного корма определен оптимальный видовой состав смешанных посевов зеленого конвейера и сенажа, установлены оптимальные сроки посева и режим использования однолетних культур. В соответствии с методикой исследования была проведена производственная проверка полученных результатов и изучена эффективность скармливания молочным коровам «сенажа в упаковке» и использования зеленого конвейера в пастбищный период для подкормки молочных коров. Разработаны и подобраны однолетние кормовые культуры для производства прогрессивной технологии «сенажа в упаковке».Включение в состав рациона молочных коров «сенажа в упаковке», повысило переваримость питательных веществ кормов, стимулировало процесс молокообразования, что дало возможность увеличить производство молока и получить дополнительный чистый доход. Эффективность использования зеленого конвейера в пастбищный период для подкормки молочных коров подтвердилась увеличением производства молока. За пастбищный период в хозяйстве надоено 2326 ц молока, в том числе от 1 фуражной коровы получено 1351 кг молока. С августа дойным коровам дополнительно к пастбищным травам давали в виде подкормки зеленую массу из вико-овсяной смеси, выращенной в виде зеленого конвейера.

In order to obtain a balanced feed, the optimal species composition of mixed crops of green conveyor and haylage was determined, the optimal sowing time and the mode of use of annual crops were established. In accordance with the methodology of the study, a production check of the results was carried out and the efficiency of feeding dairy cows «haylage in a package» and the use of a green conveyor in the pasture period for feeding dairy cows was studied. Developed and selected annual forage crops for the production of advanced technology «haylage in the package». Inclusion in the diet of dairy cows «haylage in the package», increased the digestibility of feed nutrients, stimulated the process of milk formation, which made it possible to increase milk production and obtain additional net income. The efficiency of using the green conveyor in the pasture period for feeding dairy cows was confirmed by an increase in milk production. Over the grazing period on the farm milked 2326 kg of milk, including 1 of feed the cow received 1351 kg of milk. Since August, dairy cows in addition to pasture herbs were given a green mass of Vico—oat mixture grown in the form of a green conveyor in the form of feeding.
PADR�O DE CONSUMO ALIMENTAR: UM ESTUDO ACERCA DOS H�BITOS ALIMENTARES.
Authors: Freire Maria Bianca Brasil , Nascimento Ellany Gurgel Cosme do
Published: June 2019

Introdu��o: Desde a inf�ncia, a escolha alimentar � despertada, atrav�s das sensa��es t�teis, gustativas e olfativas, sendo dessa forma imposs�vel de homogeneizar as escolhas. Objetivo: o objetivo descrever os padr�es de consumo de alimentos mais frequentemente encontrados nas publica��es cientifica. M�todo: Trata-se de uma revis�o sistem�tica da literatura, realizada nas bases de dados National Library of Medicine - PubMed e Scientific Electronic Library Online � SciELO, utilizando o termo de busca �h�bitos alimentares�. Resultados: O consolidado dos aspectos encontrados foi distribu�do em quatro categorias: alimentos saud�veis: uma analise acerca dos mesmos; ades�o � alimenta��o saud�vel; fatores relacionados a escolhas alimentares e estrat�gias para mudan�as de h�bitos alimentares. Conclus�o: Conclui-se que o padr�o alimentar atual sofre influ�ncia da agrega��o familiar, da baixa renda, da rela��o do sexo e a quest�o do peso, al�m de fatores socioculturais, imagem corporal, influ�ncia da m�dia, observando-se certo distanciamento a cerca dos h�bitos alimentares recomendados.
TECNOLOGIAS DIGITAIS E RECURSOS F�SICOS NA ABORDAGEM DE CRIAN�AS COM TRANSTORNO DO ESPECTRO AUTISTA
Authors: Pontes Evellyn L�dya Franco , Kleparde Adriana Aparecida , Silva Taynara Pereira , Puggina Ana Claudia Giesbrecht , Apostolico Ma�ra Rosa , Pina-Oliveira Alfredo Almeida
Published: June 2019

Introdu��o: Avan�os nas tecnologias digitais podem contribuir para ampliar as abordagens de educadores, profissionais de sa�de e outros envolvidos no desenvolvimento integral de crian�as com Transtorno do Espectro Autista (TEA). Objetivo: identificar potencialidades e aspectos comparativos entre o emprego de tecnologias digitais e de recursos f�sicos na abordagem de crian�as com TEA. M�todo: Trata-se de um estudo de atualiza��o por meio da an�lise comparativa entre aplicativos exclusivamente criados para ajudar na comunica��o com crian�as com TEA e os recursos f�sicos existentes com a mesma finalidade. Resultados: Os recursos f�sicos apresentados s�o o Picture Exchange Communication System (PECS), Livro de Velcro, Troca de Figuras e Rotina Di�ria. Os aplicativos m�veis Livox�, Aboard�, Tobii Sono Flex�, Autismo Imagem e Discuss�o� e o Minha Rotina Especial� s�o apresentados e discutidos em rela��o as vantagens do uso desse tipo de recurso. Conclus�o: ambos os recursos podem mediar o processo de comunica��o de crian�as com TEA e destaca-se que os aplicativos contribuem para aprimorar a qualidade das intera��es realizadas com a crian�a com TEA.
Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy
Authors: Watson Jessica , Jones Hayley E , Banks Jonathan , Whiting Penny , Salisbury Chris , Hamilton Willie
Published: June 2019

Background

Research comparing C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and plasma viscosity (PV) in primary care is lacking. Clinicians often test multiple inflammatory markers, leading to concerns about overuse.

Aim

To compare the diagnostic accuracies of CRP, ESR, and PV, and to evaluate whether measuring two inflammatory markers increases accuracy.

Design and setting

Prospective cohort study in UK primary care using the Clinical Practice Research Datalink.

Method

The authors compared diagnostic test performance of inflammatory markers, singly and paired, for relevant disease, defined as any infections, autoimmune conditions, or cancers. For each of the three tests (CRP, ESR, and PV), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under receiver operator curve (AUC) were calculated.

Results

Participants comprised 136 961 patients with inflammatory marker testing in 2014; 83 761 (61.2%) had a single inflammatory marker at the index date, and 53 200 (38.8%) had multiple inflammatory markers. For ‘any relevant disease’, small differences were seen between the three tests; AUC ranged from 0.659 to 0.682. CRP had the highest overall AUC, largely because of marginally superior performance in infection (AUC CRP 0.617, versus ESR 0.589, P<0.001). Adding a second test gave limited improvement in the AUC for relevant disease (CRP 0.682, versus CRP plus ESR 0.688, P<0.001); this is of debatable clinical significance. The NPV for any single inflammatory marker was 94% compared with 94.1% for multiple negative tests.

Conclusion

Testing multiple inflammatory markers simultaneously does not increase ability to rule out disease and should generally be avoided. CRP has marginally superior diagnostic accuracy for infections, and is equivalent for autoimmune conditions and cancers, so should generally be the first-line test.
Socioeconomic deprivation scores as predictors of variations in NHS practice payments: a longitudinal study of English general practices 2013–2017
Authors: Levene Louis S , Baker Richard , Bankart John , Walker Nicola , Wilson Andrew
Published: June 2019

Background

A previous study found that variables related to population health needs were poor predictors of cross-sectional variations in practice payments.

Aim

To investigate whether deprivation scores predicted variations in the increase over time of total payments to general practices per patient, after adjustment for potential confounders.

Design and setting

Longitudinal multilevel model for 2013–2017; 6900 practices (84.4% of English practices).

Method

Practices were excluded if total adjusted payments per patient were <£10 or >£500 per patient or if deprivation scores were missing. Main outcome measures were adjusted total NHS payments; calculated by dividing total NHS payments, after deductions and premises payments, by the number of registered patients in each practice. A total of 17 independent variables relating to practice population and organisational factors were included in the model after checking for collinearity.

Results

After adjustment for confounders and the logarithmic transformation of the dependent and main independent variables (due to extremely skewed [positive] distribution of payments), practice deprivation scores predicted very weakly longitudinal variations in total payments’ slopes. For each 10% increase in the Index of Multiple Deprivation score, practice payments increased by only 0.06%. The large sample size probably explains why eight of the 17 confounders were significant predictors, but with very small coefficients. Most of the variability was at practice level (intraclass correlation = 0.81).

Conclusion

The existing NHS practice payment formula has demonstrated very little redistributive potential and is unlikely to substantially narrow funding gaps between practices with differing workloads caused by the impact of deprivation.
Suivre l’engagement des apprenants dans l’activité de construction de cartes mentales
Authors: Carrillo Rubiela , Prié Yannick , Guillaume Leslie , Lavoué Élise
Published: June 2019

Notre travail a pour objectif d’aider les enseignants à suivre l’engagement des apprenants pendant des activités de construction de cartes mentales. Les cartes mentales sont utilisées pour aider les apprenants à organiser les contenus étudiés en classe. Étant donnée la complexité des cartes, les enseignants ont besoin d’outils qui assistent la compréhension des cartes produites et de leur processus de construction. Nous avons défini avec des enseignants un ensemble d’indicateurs d’engagement, reposant sur les traces d’interaction des apprenants. Ces indicateurs ont été implémentés dans un tableau de bord à destination des enseignants. Cet article présente la première version du tableau de bord implémenté, sa conception, son implémentation et les résultats d’une évaluation sur les aspects d’utilisabilité et d’utilité.
Peranan Guru Pendidikan Agama Kristen Terhadap Perilaku Siswa-Siswi Di SD Negeri 01 Ujung Watu Jepara
Authors: Ermindyawati Lilis
Published: June 2019

Pengajaran pendidikan Agama Kristen mempunyai peran penting dalam membantu pertumbuhan kerohanian siswa dalam lingkup pendidikan, pengajaran Pendidikan Agama Kristen pada dasarnya sangat dibutuhkan dan memiliki pengaruh yang besar terhadap perilaku siswa-siswi. Pengajaran pendidikan Agama, sangatlah penting dalam kehidupan umat manusia, terlebih khusus umat Agama Kristen.  Pendidikan Agama, lebih khususnya pendidikan Agama Kristen sangatlah penting untuk diterapkan dalam peningkatan potensi spiritual, sehingga membantu peserta didik agar menjadi manusia yang beriman dan taat kepada Tuhan. Berdasarkan hasil dari koefisien determinasi melalui perhitungan dengan SPSS 23 menghasilkan, 29,8 % artinya Pengaruh Pengajaran Pendidikan Agama Kristen memberi sumbangan yang cukup besar, atau ,29,8 % terhadap Perilaku Siswa-siswi kelas III-VI di Sekolah Dasar Negeri 01 Ujungwatu Jepara.  Sisanya (100 – 29,8 % = 61,2 %) di pengaruhi oleh faktor yang lain. Berdasarkan hasil penelitian ini, maka guru perlu memperhatikan setiap perilaku siswa-siswinya sehari-hari dan selalu bijak dan bertindak terlebih dalam hal memberi Pengajaran Pendidikan Agama Kristen.
Keseimbangan Pertumbuhan Spiritual dan Intelektual: Teladan Yesus dan Paulus bagi Hamba Tuhan Masa Kini
Authors: Baskoro Haryadi , Siburian Hendro Hariyanto
Published: June 2019

Ketidakseimbangan antara spiritualitas dan intelektualitas terbukti sering mengganggu pertumbuhan pelayanan hamba-hamba Tuhan. Bahkan ketidakseimbangan itu bisa menjerumuskan hamba Tuhan dalam kesesatan dan kejatuhan.  Melalui studi Alkitab (eksegesa) dan penelitian kualitatif, peneliti mencoba memahami keteladanan Yesus dan Paulus sebagai model pertumbuhan yang seimbang antara spiritualitas dan intelektualitas.            Dari pembahasan ditemukan kebenaran penting bahwa Yesus dan Paulus adalah figur-figur pelayan yang melayani dengan kompetensi ganda: spiritual dan intelektual. Kompetensi ganda itu dikembangkan dalam rangka menunaikan tugas pelayanan. Pengembangan kompetensi ganda itu berdasarkan Alkitab, Firman Tuhan. Mengacu pada Yesus dan Paulus, hamba Tuhan masa kini juga harus bertumbuh seimbang dalam kompetensi ganda itu. Keseimbangan antara spiritualitas dan intelektualitas menjadikan hamba Tuhan lebih sehat secara rohani, terjaga dari kesesatan, kritis dan cerdas, namun tetap menyala-nyala di dalam Roh Kudus. Kompetensi ganda akan memampukan hamba Tuhan masa kini melakukan pelayanan-pelayanan besar. Dan ketika keberhasilan itu diperoleh, kompetensi ganda itu akan menjaga agar hamba Tuhan tidak terjatuh.  Kata kunci: spiritualitas, intelektualitas, keseimbangan, pelayanan, Alkitabiah.                The imbalance between spirituality and intellect has often been shown to disrupt the growth of the ministry of God's servants. Even that imbalance can plunge the servant of God in error and fall. Through Bible study (exegesis) and qualitative research, researchers try to understand Jesus and Paul as models of balanced growth between spirituality and intellect.               From the discussion I discovered the important truth, that Jesus and Paul are servant figures who serve with multiple competencies: spiritual and intellectual. Double competency was developed in order to fulfill service duties. The development of multiple competencies is based on the Bible, God's Word. Referring to Jesus and Paul, God's servants today must also grow in balance in that dual competence. The balance between spirituality and intellect makes the Lord's servant have spiritual health, maintained from heresy, critical and intelligent, but still on fire in the Holy Spirit. Multiple competencies will enable God's servants today to carry out great services. And when the success is obtained, that dual competence will keep the servants of God from falling. Key words: spirituality, intelect, balance, service, Biblical.
Ibadah Jemaat Kristen Kontemporer Abad 21 Dan Tinjauan Kritis-Liturgis
Authors: Panjaitan Firman , Lumingkewas Marthin Steven
Published: June 2019

Fenomena liturgi dewasa ini begitu dikuasai oleh berbagai macam bentuk ibadah yang bersifat ‘kekinian’, atau yang dikenal dengan istilah ibadah kontemporer. Jenis ibadah ini sudah merebak dengan sangat jauh dan bahkan menjadi ibadah yang begitu disukai oleh setiap anak muda (tidak menutup kemungkinan orang tua juga), sehingga muncul anggapan bahwa jenis ibadah ini adalah jenis ibadah yang perlu untuk terus dipertahankan dan dikembangkan.Tulisan ini hendak mencoba melihat dengan kritis bentuk ibadah kontemporer dan sekaligus membedahnya dengan pisau analitis-teologis yang cukup tajam untuk menemukan apa saja yang harus dikembangkan dan diupayakan dalam menjalankan ibadah kontemporer ini. Jangan sampai ibadah kontemporer menjadi sebuah ibadah yang hanya mengutamakan kepuasan jasmaniah saja tetapi melupakan pertumbuhan dan perkembangan iman. Oleh sebab itu, dalam tulisan ini disajikan sebuah ulasan kritis yang hendak membenahi bentuk ibadah kontemporer sehingga dapat menjadi bentuk ibadah yang benar-benar sesuai dengan apa yang dikehendaki oleh Tuhan dan sekaligus menyenangkan hati Tuhan.
The effect of long-term fertilization on phosphorus content determined in different soil extractants on meadow chernozem soil
Authors: Emese B. Szabó
Published: June 2019

The 0.01 M CaCl2 universal extractant is known all over Europe since the 90’s. During my research, I exam the phosphorus content determined in 0.01 M CaCl2 of the samples originated from the B 17 National Uniformed Long Term Fertilisation Trials in the experimental site Karcag, in the 40th year of the experiment. Relationships between the CaCl2-P and the AL-P content of the soil, the average yields, and the phosphorus balance of the2006/2007 year were studied. From the results of the study it was concluded as follows:– Correlation was close (r=0.68-0.7) between the AL-P and CaCl2-P. This is in accordance with the results of previous experiments in Hungary and other countries.– My studies confirmed that the calcium-chloride method indicates well the deficiency and the surplus of plant available phosphorus. In case of different degrees of negative balance, the amount of CaCl2 extractable phosphorus showed no changes, or decreased, and in case of positive balance it increased exponentially by the long-term effect of P rates.– The 120 and 180 kg ha-1 rates resulted in significant increases in the amount of CaCl2-P according to the control and treatments that are not fertilized with phosphorus. The 60 kg ha-1 rate didn’t result any increase as it didn’t meet the phosphorus requirement of winter wheat, and presumably the P-balance was negative in the earlier years as well.– It can be stated that the 0.01 M CaCl2 was able to assess the deficiency and the excess of phosphorus causing negative impacts on environment as well.
KORELASI ANTARA PENDIDIKAN DAN UMUR DENGAN PENGETAHUAN IBU HAMIL TENTANG ANEMIA
Authors: Ariningtyas Ristiana Eka , Hardianti Titin
Published: June 2019

Low consumption  of  Fe tablets in pregnant wome is the cause of anemia prevalence in Yogyakarta City. Sleman regency is the district with the highest Fe cell coverage rate among other districts. Godean II Community Health Centers, recorded the highest incidence of maternal anemia was 25,81%. Examination of hemoglobin  (Hb) in 217 pregnant women, the result is 86 anemia pregnant women. The design of this study used Analytical Survey with Cross Sectional, sample amounted 30 pregnant women used saturated sampling technique, statistic test  used Chi Square. The results of the study can be concluded that there was a correlation between education and knowledge of pregnant mothers about Anemia in Godean II Community Health Centers, Sleman Regency with p-value of 0,019 and odd ratio value of 9,33. There was correlation between age with knowledge of pregnant woman about Anemia Godean II Community Health Center, Sleman Regency with p-value equal to 0,004 and odd ratio value 20,0.

 Keywords: Knowledge, Pregnant Women, Anemia

ABSTRAK

 Konsumsi tablet  Fe yang rendah pada ibu hamil menjadi penyebab tingginya prevalensi anemia di Kota Yogyakarta.  Cakupan tablet Fe tertinggi ada di Kabupaten Sleman dibndingkan dengan  kabupaten lainnya. Kasus anemia ibu hamil sebesar 25,81% yang tercatat di Puskesmas Godean II wilayah Kabupaten Sleman, dan merupakan  kasus tertinggi. Pemeriksan hemoglobin (Hb) pada 217 ibu hamil, didapatkan hasil 86 ibu hamil anemia. Penelitian ini menggunakan Survei Analitik dengan rancanagan Cross Sectional, sampel berjumlah 30 ibu hamil, diambil dengan teknik sampling jenuh, uji statistik dengan Chi Square. Hasil penelitian  menunjukkan ada korelasi antara pendidikan dengan pengetahuan ibu hamil tentang Anemia ditunukkan dengan nilai p sebesar 0,019 dan nilai odd ratio sebesar 9,33. Korelasi antara umur dengan pengetahuan ibu hamil tentang anemia di Puskesmas Godean  II, Kabupaten Sleman dengan nilai p sebesar 0,004 dan nilai odd ratio sebesar 20,0.

 Kata Kunci : Pengetahuan, Ibu Hamil, Anemia
THE SUBJECT OF ASSETS VALUATION CONTRIBUTED CAPITAL TO BUSINESS UNDER THE PROVISIONS OF BUSINESS LAW IN 2014
Authors: Ngo Thao Thi Phuong , Do Thu Thi Mai
Published: June 2019

The article refers to the legal provisions of Business Law in 2014 on the subject of assets valuation contributed capital to the types of businesses: limited liability  company, partnership, joint-stock company. This article does not discuss businesses with foreign elements and State businesses. From the analysis of legal  provisions, this article has pointed out the limitations of the law on the subject of assets valuation contributed capital to business, and proposed the ways to improvement of the law on this issue.
FACTORS INFLUENCING REVISIT DECISION OF INTERNATIONAL TOURISTS IN CAN THO CITY
Authors: Dinh Thanh Cong , Pham Nhung Le Hong
Published: June 2019

This study aims to identify factors that affect the revisit decision of international tourists in Can Tho city. The data was collected by interviewing 110 foreign tourists. The result of binary logistic regression identifies four important factors that have possitive impacts on the revisit decision including: (i) perception ofinternational tourist, (ii) tourism infrastructure, (iii) tourism resources and (iv) travel demand. Particularly, perception of international tourist has the strongest effect on the revisit decision. The study also proposes the solutions for enticing more foreign tourists to revisit Can Tho city.
APPLICATION OF THE REAL – TIME PCR FOR THE DETECTION OF CYP2C19*2 SINGLE NUCLEOTIDE POLYMORPHISM IN PATIENS WITH GASTRITIS AT TRA VINH GENERAL HOSPITAL
Authors: Ngo Duy Anh , Tran Trung Thien , Nguyen Anh Tuan , Nguyen Thanh Tien
Published: June 2019

The aim of this study is to identify CYP2C19*2 single nucleotide polymorphisms in patients with gastritis at TraVinh General Hospital. A cross-sectional study was conducted in 280 endoscopic gastric biopsy samples of patients with gastritis at TraVinh General Hospital. CYP2C19*2 genotypes were determined by realtime PCR method using TaqMan probes. Data were stored and analyzed by IBM SPSS Statistic (version 20.0; Armonk, New York, USA) and Excel 2010. The prevallelece of GG, AG and AA genotypes were 51.8, 39.6 and 8.6% correspondingly. The ratio of allele G and A were 0.716 and 0.284 respectively. The correlation of CYP2C19*2 polymorphisms with age (p=0.891), gender (p=0.652) was not significantly distinguished
HEALTH RISKS ASSOCIATED WITH WASTE ACCUMULATION IN THE CONTEXT OF ENVIRONMENTAL LAWS OF DEVELOPMENT
Authors: Ustinova Іryna , Trakhtengerz Grygoryi
Published: June 2019

This work highlights the results of studies of
environmental laws of development of urban systems that
determine the cause of waste accumulation. It was disclosed
that environmental pollution is an ultimative environmental
factor that increases its pressure on humanity and sign of
imbalance of ecological system.
A Catalog of Known Galactic K-M Stars of Class I Candidate Red Supergiants in Gaia DR2
Authors: Messineo M. , Brown A. G. A.
Published: June 2019

We investigate individual distances and luminosities of a sample of 889 nearby candidate red supergiants (RSGs) with reliable parallaxes (ϖ/σ

ϖ
 > 4 and RUWE < 2.7) from Gaia Data Release 2 (DR2). The sample was extracted from the historical compilation of spectroscopically derived spectral types by Skiff, and consists of K-M stars that are listed with class I at least once. The sample includes well-known RSGs from Humphreys, Elias et al., Jura & Kleinmann, and Levesque et al. Infrared and optical measurements from the Two Micron All Sky Survey, Catalog of Infrared Observations (CIO), Midcourse Space Experiment, Wide-field Infrared Survey Explorer, MIPSGAL, Galactic Legacy Infrared Midplane Extraordinaire (GLIMPSE), and The Naval Observatory Merged Astrometric Dataset catalogs allow us to estimate the stellar bolometric magnitudes. We analyze the stars in the luminosity versus effective temperature plane and confirm that 43 sources are highly probably RSGs with

M

bol

 < −7.1 mag. Of the stars in the sample, 43% have masses >7 M
⊙. Another ≈30% of the sample consists of giant stars.
Optimizing Ground-based Observations of O2 in Earth Analogs
Authors: López-Morales Mercedes , Ben-Ami Sagi , Gonzalez-Abad Gonzalo , García-Mejía Juliana , Dietrich Jeremy , Szentgyorgyi Andrew
Published: June 2019

We present the result of calculations to optimize the search for molecular oxygen, O2, in Earth analogs transiting around nearby, low-mass stars using ground-based, high-resolution Doppler shift techniques. We investigate a series of parameters, namely spectral resolution, wavelength coverage of the observations, and sky coordinates and systemic velocity of the exoplanetary systems, to find the values that optimize detectability of O2. We find that increasing the spectral resolution of observations to R ∼ 300,000–400,000 from the typical R ∼ 100,000 more than doubles the average depth of O2 lines in planets with atmospheres similar to Earth’s. Resolutions higher than ∼500,000 do not produce significant gains in the depths of the O2 lines. We confirm that observations in the O2
A-band are the most efficient except for M9V host stars, for which observations in the O2 near-infrared (NIR) band are more efficient. Combining observations in the O2
A, B, and NIR bands can reduce the number of transits needed to produce a detection of O2 by about one-third in the case of white noise limited observations. However, that advantage disappears in the presence of typical levels of red noise. Therefore, combining observations in more than one band produces no significant gain versus observing only in the A band, unless red noise can be significantly reduced. Blending between the exoplanet’s O2 lines and telluric O2 lines is a known problem. We find that problem can be alleviated by increasing the resolution of the observations, and by giving preference to targets near the ecliptic.
Constraining Strangeness in Dense Matter with GW170817
Authors: Gomes R. O. , Char P. , Schramm S.
Published: June 2019

Particles with strangeness content are predicted to populate dense matter, modifying the equation of state of matter inside neutron stars as well as their structure and evolution. In this work, we show how the modeling of strangeness content in dense matter affects the properties of isolated neutron stars and the tidal deformation in binary systems. For describing nucleonic and hyperonic stars we use the many-body forces model at zero temperature, including the ϕ mesons for the description of repulsive hyperon–hyperon interactions. Hybrid stars are modeled using the MIT Bag Model with vector interaction (vMIT) in both Gibbs and Maxwell constructions, for different values of bag constant and vector interaction couplings. A parameterization with a Maxwell construction, which gives rise to a third family of compact stars (twin stars), is also investigated. We calculate the tidal contribution that adds to the post-Newtonian point-particle corrections, the associated love number for sequences of stars of different composition (nucleonic, hyperonic, hybrid, and twin stars), and determine signatures of the phase transition on the gravitational waves in the accumulated phase correction during the inspirals among different scenarios for binary systems. In light of the recent results from GW170817 and the implications for the radius of ∼1.4 M
⊙ stars, our results show that hybrid stars can only exist if a phase transition takes place at low densities close to saturation.
Spectropolarimetric Characteristics of Brown Dwarfs. II. Uniform Clouds
Authors: Sanghavi Suniti , West Robert
Published: June 2019

Scattering processes in the atmosphere of a fast-rotating brown dwarf (BD) or self-luminous extrasolar giant planet (EGP) produce distinct polarimetric, in addition to spectrometric, signatures. An ability to unambiguously interpret these signals would improve our understanding of their atmospheric evolution, structure, and dynamics. To this end, we have incorporated molecular opacities to define the wavelength-dependent vertical structure of the atmosphere as a function of the internal energy, surface gravity, and metallicity of the BD. This allows us to use our recently developed semianalytic conics-based radiative transfer framework to generate realistic spectropolarimetric simulations. We have examined the simulated effects of the internal energy and surface gravity of BDs and of the grain size and atmospheric depth of clouds on polarized spectra in the J, H, and K near-infrared bands. We find that T-dwarf spectra can be fit more easily using cloudless atmospheres or high clouds, while fitting L-dwarf spectra requires an assumption of deep clouds. Polarimetry contains a wealth of information orthogonal to what can be obtained from photometry alone. However, under current limits of instrument sensitivity, the greatest benefits of polarimetry will apply to high clouds bearing small grains. Future work will examine the effect of gravitational darkening and disequilibrium chemistry on the spectropolarimetry of these BDs.
Episodic Jets from Black Hole Accretion Disks
Authors: Shende Mayur B. , Subramanian Prasad , Sachdeva Nishtha
Published: June 2019

Several active galactic nuclei and microquasars are observed to eject plasmoids that move at relativistic speeds. We envisage the plasmoids as pre-existing current carrying magnetic flux ropes that were initially anchored in the accretion disk corona. The plasmoids are ejected outwards via a mechanism called the toroidal instability (TI). The TI, which was originally explored in the context of laboratory tokamak plasmas, has been very successful in explaining coronal mass ejections from the Sun. Our model predictions for plasmoid trajectories compare favorably with a representative set of multi-epoch observations of radio emitting knots from the radio galaxy 3C 120, which were preceded by dips in X-ray intensity.
Probing the Assembly of Dwarf Galaxies through Cosmic Time with Damped Lyα Absorption Spectroscopy
Authors: Jeon Myoungwon , Besla Gurtina , Bromm Volker
Published: June 2019

We investigate the absorption features associated with a gas-rich dwarf galaxy, using cosmological hydrodynamics simulations. Our goal is to explore whether the progenitors of the lowest-mass dwarf galaxies known to harbor neutral hydrogen today (

,

) could possibly be detected as Damped Lyα Absorbers (DLAs) over cosmic time. We trace the evolution of a single dwarf galaxy, preselected to contain DLAs, from the era of the first metal-free, so-called Population III (Pop III) stars, down to z = 0, thus allowing us to study the metal enrichment history of DLAs associated with the simulated galaxy. We find that the progenitors of the simulated dwarf are expected to be seen for most of their evolution as DLAs that are contaminated by normal, Population II stars. The time period during which DLAs are only metal-enriched by Pop III stars, on the other hand, is likely very brief, confined to high redshifts, z ≳ 6. The susceptibility of the dwarfs to the external UV radiation background allows them to preserve neutral gas only at the center (a few ∼100 pc). This results in a small probability that the simulated dwarf would be observed as a DLA. This study suggests that DLAs are unlikely to be hosted in the lowest-mass dwarfs that can harbor neutral gas (

), below which neutral gas is unlikely to exist. However, this study does illustrate that, when detected, absorption lines provide a powerful method for probing ISM conditions inside the smallest dwarf galaxies at intermediate to high redshifts.
Benchmark Rovibrational Linelists and Einstein A-coefficients for the Primordial Molecules and Isotopologues
Authors: Amaral Paulo H. R. , Diniz Leonardo G. , Jones Keith A. , Stanke Monika , Alijah Alexander , Adamowicz Ludwik , Mohallem José R.
Published: June 2019

Complete benchmark rovibrational energy linelists calculated for the primordial polar molecules of the universe, namely HD+, HD, and the HeH+ isotopologues, with accuracy up to 10−2 cm−1 for low-lying states, are presented. To allow for these calculations to be performed, new high-accuracy potential energy curves, which include the diagonal Born–Oppenheimer adiabatic corrections and the leading relativistic corrections, are determined. Also, a new approach for calculating non-adiabatic corrections involving an effective vibrational nuclear mass obtained based on the atoms-in-molecules theory is employed. The vibrational and rotational masses are taken as being different and dependent on the nuclear distance. Accurate dipole moment curves are calculated and used to generate lists of Einstein A-coefficients. The energy linelists and the sets of Einstein A-coefficients for HD are upgrades of previous calculations including quasibound states, while for HD+ and HeH+ and its isotopologues the present results represent significant improvement over the previous calculations. The results obtained here suggest that, with the inclusion of the non-adiabatic corrections, the accuracy limit at least for low-lying states might have been reached. Thus, further progress should involve accounting for even smaller effects such as the quantum-electrodynamics corrections. The present results represent the state-of-the-art of theoretical spectroscopy of the primordial polar molecules.
Detection of 4765 MHz OH Emission in a Preplanetary Nebula: CRL 618
Authors: Strack A. , Araya E. D. , Lebrón M. E. , Minchin R. F. , Arce H. G. , Ghosh T. , Hofner P. , Kurtz S. , Olmi L. , Pihlström Y. , Salter C. J.
Published: June 2019

Jets and outflows are ubiquitous phenomena in astrophysics, found in our Galaxy in diverse environments, from the formation of stars to late-type stellar objects. We present observations conducted with the 305 m Arecibo Telescope of the preplanetary nebula CRL 618 (Westbrook Nebula)—a well-studied late-type star that has developed bipolar jets. The observations resulted in the first detection of 4765 MHz OH in a late-type stellar object. The line was narrow (FWHM ∼ 0.6 km s−1) and ∼40 km s−1 blueshifted with respect to the systemic velocity, which suggests association with the expanding jets/bullets in CRL 618. We also report nondetection at Arecibo of any other OH transition between 1 and 9 GHz. The nondetections were obtained during the observations in 2008, when the 4765 MHz OH line was first discovered, and also in 2015 when the 4765 MHz OH line was not detected. Our data indicate that the 4765 MHz OH line was a variable maser. Modeling of the 4765 MHz OH detection and nondetection of the other transitions is consistent with the physical conditions expected in CRL 618. The 4765 MHz OH maser could originate from dissociation of H2O by shocks after sublimation of icy objects in this dying carbon-rich stellar system, although other alternatives such as OH in an oxygen-rich circumstellar region associated with a binary companion are also possible.
A New Class of Large-amplitude Radial-mode Hot Subdwarf Pulsators
Authors: Kupfer Thomas , Bauer Evan B. , Burdge Kevin B. , Bellm Eric C. , Bildsten Lars , Fuller Jim , Hermes JJ , Kulkarni Shrinivas R. , Prince Thomas A. , van Roestel Jan , Dekany Richard , Duev Dmitry A. , Feeney Michael , Giomi Matteo , Graham Matthew J. , Kaye Stephen , Laher Russ R. , Masci Frank J. , Porter Michael , Riddle Reed , Shupe David L. , Smith Roger M. , Soumagnac Maayane T. , Szkody Paula , Ward Charlotte
Published: June 2019

Using high-cadence observations from the Zwicky Transient Facility at low Galactic latitudes, we have discovered a new class of pulsating, hot compact stars. We have found four candidates, exhibiting blue colors (g − r ≤ −0.1 mag), pulsation amplitudes of >5%, and pulsation periods of 200–475 s. Fourier transforms of the light curves show only one dominant frequency. Phase-resolved spectroscopy for three objects reveals significant radial velocity, T
eff, and

variations over the pulsation cycle, which are consistent with large-amplitude radial oscillations. The mean T
eff and

for these stars are consistent with hot subdwarf B (sdB) effective temperatures and surface gravities. We calculate evolutionary tracks using MESA and adiabatic pulsations using GYRE for low-mass, helium-core pre-white dwarfs (pre-WDs) and low-mass helium-burning stars. Comparison of low-order radial oscillation mode periods with the observed pulsation periods show better agreement with the pre-WD models. Therefore, we suggest that these new pulsators and blue large-amplitude pulsators (BLAPs) could be members of the same class of pulsators, composed of young ≈0.25–0.35 M
⊙ helium-core pre-WDs.
An Atypical Presentation of a Strangulated Bochdalek Hernia in a 60-Year-Old Man
Authors: Coco Danilo , Leanza Silvana
Published: June 2019

BACKGROUND: Bochdalek hernia is a type of congenital diaphragmatic hernia (CDH), which more commonly affects children. Congenital left diaphragmatic hernias, such as Bochdalek, rarely occur in adults. Most such cases do not present any symptoms. CASE PRESENTATION: Here, we report the case of a 60-year-old male with a left-sided Bochdalek diaphragmatic hernia, who presented with abdominal pain and dyspnea. The patient was successfully treated by laparoscopic approach.CONCLUSION: The 60-year-old male patient had left-sided BH and was successfully cured by the laparoscopic approach.
The Protective Effect of Nitroglycerin, N-Acetyl Cysteine and Metoprolol in CCL4 Induced Animal Model of Acute Liver Injury
Authors: Al-Jawad Faruk H. , Al-Attar Zaid , Abbood Muayyad S.
Published: June 2019

OBJECTIVE: The current study was designed to determine the hepatoprotective effect of well-known drugs. Nitroglycerin, N-acetyl cysteine and Metoprolol in acute liver injury induced by CCL4. The antioxidant effects of b-blockers, especially carvedilol, have been described by several investigators. However, for metoprolol, the effect is a bit query as there is only one in-vitro study showing a little hepatoprotective effect. Thus, it is worthy to re-study the hepatoprotective effect of metoprolol. AIM: To explore the possible hepatoprotective effect of Nitroglycerin, N-acetyl cysteine and Metoprolol TartrateMATERIAL AND METHODS: The normal serum values of ALP, AST, ALT, TSB and TSP were determined in 35 healthy rabbits allocated to 5 groups before CCL4 induction and at three occasions 24, 72, 120 hrs after induction by CCL4 and treatment with the tested drugs: Nitroglycerin, N-acetyl cysteine and Metoprolol for five successive days.RESULTS: Showed significant decrease in serum levels of ALP, AST, ALT and TSB with a significant increase in TSP level of all the tested drugs measured at 120 hrs compared with the control and their levels measured at 24, 72 hrs.CONCLUSION: All the tested drugs proved in having a hepatoprotective effect when they are given orally to animals. The histopathological sections of the liver tissue supported the real effect of these drugs in the management of ALI.
The usefulness of Veno-Arterial Extracorporeal Membranous Oxygenation in Patients with Cardiogenic Shock
Authors: Abouelwafa Mohamed , Radwan Waheed , Abdelfattah Alia , Abdelbary Akram , Khaled Mohamed , Samy Wael , Yousry Mohamed , Saed Ahmed , Saad Mahmood
Published: June 2019

BACKGROUND: Venoarterial extracorporeal membranous oxygenation is a form of temporary mechanical circulatory support that gets as a salvage technique in patients with cardiogenic shock, we intended to evaluate the effect of (VA ECMO) support on hemodynamics and lactate levels in patients with cardiogenic shock.AIM: The aim of our study is to detect the ability to introduce veno-arterial extracorporeal membranous oxygenation (VA ECMO) as a temporary extracorporeal life support system (ECLS) in our unit, demonstrate the role of ECMO in cardiogenic shock patients regarding improving hemodynamics and microcirculation, and demonstrate the complications and drawbacks in our first center experience regarding VA ECMO.MATERIAL AND METHODS: This was a single-centre observational study that included 10 patients admitted with cardiogenic shock for which VA ECMO was used as mechanical circulatory support. RESULTS: The MAP increased after initiation of the support. It was 41.8 ± 9.3 mmHg and 59.5 ± 6.8 mmHg (P = 0.005). The use of VA ECMO support was associated with a statistically significant decrease in the base deficit (-10.6 ± 4.2 and -6.3 ± 7.4, P = 0.038). The serum lactate declined from 5.9 ± 3.5 mmoL/L to 0.6 ± 4.4 mmoL/L by the use of VA ECMO; a statistically significant change (P = 0.005).CONCLUSIONS: We concluded that VA ECMO as mechanical support for patients with cardiogenic shock might improve mean arterial blood pressure, base deficit and lactate clearance.
Making Known and Available: The importance of digitization of a historical malacological collection in the Science Museum of the University of Coimbra
Authors: Breves André , Girão da Cruz M. Teresa , Casaleiro Pedro
Published: June 2019

The Science Museum of the University of Coimbra (MCUC) manages the oldest zoological collections in Portugal. The molluscs are among the most relevant invertebrates within this collection, with over one hundred thousand specimens. A significant part of the Portuguese malacological collection in MCUC comes from the Madeira Archipelago, a group of oceanic islands with a high diversity of terrestrial molluscs and a hotspot of endemic taxa.

A recent review of land snails from Madeira hosted at the MCUC revealed that there were around 130 lots and 2,000 specimens offered by naturalists since the 19th Century and none of them had been previously digitized. A significant number of these specimens was offered by António da Costa de Paiva (Barão de Castelo de Paiva) who described ten land snail species from the Madeira Archipelago in 1866 and published an extensive monograph on non-marine molluscs in 1867.

The main goal of our work was to carry out the inventory of the mollusc collections from the Madeira Archipelago in the database of MCUC, and to discuss the importance of specimens’ digitization for making the collections known and available to researchers and the general public.

We inserted data for 1,916 specimens of the Madeira Archipelago collection in the MCUC database ‘In Natura - Natural Heritage Management’ with information on their taxonomy, old inventory numbers (if available), correspondent lot, collector and the study areas, complemented with information about habitat, among others. In addition, we also included photographs of the lots and of some of the most remarkable individuals in the database. The specimens were then reconditioned and identified in the general mollusc collection, although the identification and designation of the type material are still lacking.

Digitization is crucial in the field of biological collections in order to transfer specimen data onto worldwide accessible repositories, potentially benefiting the work of researchers and other stakeholders in the ecological and conservation communities. For instance, even when researchers are intensively searching for a type material in a certain collection, if the data are neither known nor available, they cannot trace it and compare it with their material.

Thus, this work is fundamental for the accessibility of the malacological collections in the MCUC for researchers and also the society-at-large that has the possibility of consulting them through the digital museum (http://museudaciencia.inwebonline.net), as well as for the dissemination of the important historical and scientific heritage of the University of Coimbra and Portugal, both nationally and internationally.
SpOccSum: An easy-to-use Python tool to summarize species occurrence data from material examined lists in taxonomic revisions
Authors: Trizna Michael , Dikow Torsten
Published: June 2019

Taxonomic revisions contain crucial biodiversity data in the material examined sections for each species. In entomology, material examined lists minimally include the collecting locality, date of collection, and the number of specimens of each collection event. Insect species might be represented in taxonomic revisions by only a single specimen or hundreds to thousands of specimens. Furthermore, revisions of insect genera might treat small genera with few species or include tens to hundreds of species. Summarizing data from such large and complex material examined lists and revisions is cumbersome, time-consuming, and prone to errors. However, providing data on the seasonal incidence, abundance, and collecting period of species is an important way to mobilize primary biodiversity data to understand a species’s occurrence or rarity. Here, we present SpOccSum (Species Occurrence Summary)—a tool to easily obtain metrics of seasonal incidence from specimen occurrence data in taxonomic revisions. SpOccSum is written in Python (Python Software Foundation 2019) and accessible through the Anaconda Python/R Data Science Platform as a Jupyter Notebook (Kluyver et al. 2016). The tool takes a simple list of specimen data containing species name, locality, date of collection (preferably separated by day, month, and year), and number of specimens in CSV format and generates a series of tables and graphs summarizing:

number of specimens per species,

number of specimens collected per month,

number of unique collection events, as well as

earliest, and

most recent collecting year of each species.

number of specimens per species,

number of specimens collected per month,

number of unique collection events, as well as

earliest, and

most recent collecting year of each species.

The results can be exported as graphics or as csv-formatted tables and can easily be included in manuscripts for publication. An example of an early version of the summary produced by SpOccSum can be viewed in Tables 1, 2 from Markee and Dikow (2018). To accommodate seasonality in the Northern and Southern Hemispheres, users can choose to start the data display with either January or July. When geographic coordinates are available and species have widespread distributions spanning, for example, the equator, the user can itemize particular regions such as North of Tropic of Cancer (23.5˚N), Tropic of Cancer to the Equator, Equator to Tropic of Capricorn, and South of Tropic of Capricorn (23.5˚S). Other features currently in development include the ability to produce distribution maps from the provided data (when geographic coordinates are included) and the option to export specimen occurrence data as a Darwin-Core Archive ready for upload to the Global Biodiversity Information Facility (GBIF).