bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the adaptive properties of potato varieties (Solanum tuberosum L.) according to the main economic and valuable characteristics
Authors: Korol L. V. , Topchii O. V. , Ivanytska A. P. , Bezprozvana I. V. , Piskova O. V. , Kostenko A. V.
Published: May 2023

Purpose. To carry out an analysis of the ecological plasticity and stability of the characteristics of productivity, starch content, dry matter and to determine the parameters of ecological adaptability of potato varieties based on the characteristic “yield” in the soil-climatic zones of the Forest-Steppe and Polissia.
Methods. The following methods were used in the research: laboratory, computational and statistical; to draw conclusions – analysis and synthesis.
Results. The results of the analysis of potato varieties grown in different soil and climatic zones of Ukraine in terms of yield, starch and dry matter content are given. Promising varieties for selection and practical use with high indicators of adaptability, stability and plasticity were identified. It was found that the highest productivity results were obtained for the variety ‘RANOMI’ in the Forest-Steppe and Polissia zones – 34.6; 28.2 t/ha and high adaptability potential – 1.28; 1.27. The varieties ‘RANOMI’, ‘Cherie’ performed best in the Forest-Steppe zone with yields of 34.6 and 31.4 t/ha, in Polissia conditions – the varieties ‘RANOMI’, ‘PARADISO’ – 28.2 and 27.4 t/ha. The varieties with high plasticity were distinguished by starch and dry matter content (‘7 FOUR 7’, ‘PARADISO’, ‘FONTANE’, ‘RANOMI’, ‘LAUDINE’), productivity (‘7 FOUR 7’, ‘Rodriga’, ‘ALOUETTE’, ‘PARADISO’, ‘LAUDINE’). The varieties ‘Mysteriia’, ‘7 FOUR 7’, ‘LAUDINE’, ‘FONTANE’ and ‘LAUDINE’ proved to be very stable in terms of productivity and the varieties ‘Mysteriia’, ‘7 FOUR 7’, ‘Rodriga’, ‘PARADISO’, ‘RANOMI’ in terms of dry matter and starch content. The varieties with the highest productivity were ‘Rodriga’, ‘PARADISO’, and for dry matter and starch content – ‘FONTANE’, ‘LAUDINE’.
Conclusions. In different soil and climatic zones, highly plastic varieties were selected according to yield index – ‘7 FOUR 7’, ‘Rodriga’, ‘ALOUETTE’, ‘PARADISO’, ‘LAUDINE’, according to starch and dry matter content – varieties ‘7 FOR 7’, ‘PARADISO’, ‘FONTANE’, ‘RANOMI’, ‘LAUDINE’. It was found that on average for 2019–2020 the highest productivity and high adaptive potential in the Forest-Steppe and Polissia zones had the variety ‘RANOMI’ – 34.6; 28.2 t/ha, respectively, CA – 1.28; 1.27. In the Forest-Steppe zone it is worth mentioning the varieties ‘Cherie’, ‘Rodriga’ with average CA index 1.15; 1.12 and productivity – 31.4; 30.62 t/ha, in the Polissia zone – ‘PARADISO’, ‘Rodriga’ with CA value – 1.20; 1.11 and productivity – 27.4; 25.5 t/ha.
Evaluation of informativeness of mutation groups of Nigella damascena L. M2 generation
Authors: Hubanova Yu. S.
Published: May 2023

Purpose. To carry out a mathematical and statistical evaluation of the mutagenesis data of the M2 generation of Nigella damascena varieties ‘Berehynia’ and ‘Charivnytsia’ in order to identify relationships between groups of mutations and mathematical justification of their use in the process of further analysis and selection of hereditary changes of mutant plants.
Methods. Seeds of the varieties ‘Berehynia’ and ‘Charivnytsia’ were treated with chemical mutagens. The mutations identified by visual observation of the plants at different stages of their growth and development were divided into eight groups. In each group of each treatment option, the frequency of mutations was calculated as a function of the type of mutagen, its concentration and exposure time. The mathematical and statistical evaluation of the results was carried out using the MS Excel analysis package and Spearman’s rank correlation.
Results. The mutational difference in the M2 generation between eight groups of Nigella damascena varieties ‘Berehynia’ and ‘Charivnytsia’ under the influence of the mutagens ethyl methanesulfonate, nitrosomethylurea and the new chemical mutagen DG-2 (a complex of 3-N,N-dimethylamino sulfonane with dimethyl) was identified and evaluated. It was found that the correlation value of the mutagenic effects ranged from 0.437 to 0.752 with significance levels from 3.540 ´ 10–5 to 0.037. The following groups of mutations can be considered informative: stem, shoot and leaf structures; flower structure; colour of the corolla petals; structure of the capsule; physio­logical changes in the process of growth and development.               
Conclusions. The effect of the mutagens EMS, NMU in concentrations of 0.01 and 0.05% and DG-2 in concentrations of 0.5 and 0.05% was determined on Nigella damascena varieties ‘Berehynia’ and ‘Charivnytsia’ after exposure for 6 and 16 hours. Mutations in the structure of the stem, shoots and leaves, the colour of the petals of the corolla, the structure of the flower and capsule, and those causing a violation of chlorophyll synthesis should be considered informative.
Cowpea (Vigna Savi.) is a promising crop for Ukraine: importance, biological and ecological features and productive potential of plants
Authors: Bondarchuk O. P. , Rakhmetov D. B. , Vergun O. M. , Rakhmetova S. O. , Daudi A. M.
Published: May 2023

Purpose. To carry out an analysis of domestic and foreign scientific literature sources, information resources and the results of previous studies, based on which to evaluate the biological and ecological features and productive potential of plants Vigna genus and to determine their prospects for introduction in Ukraine.
Methods. In the process of research, inventory information of NBG collection funds, catalogs of botanical gardens of Ukraine, directories, registers of varieties were used. Printed and electronic scientific periodicals and searchable scientific databases (Scopus, Web of Science, Pubmed, Researchgate, Research4Life, Science Direct, Google Scholar) were involved in the information search. The work used methods of introduction, analysis, systematization, comparison, and generalization of information data.
Results. In the course of the screening of literary sources, it was found that the center of origin of plants of the genus Vigna is considered to be West Africa. Archaeological finds of these representatives date back to the IV millennium BC. Today, their natural and cultigenic ranges cover the Holarctic, Paleotropical, Neotropical and Australian realms. The genus Vig­na includes 105 species of plants, of which about 10 species are known in culture today, which are characterized by high heat, drought, acid and salt resistance, capable of providing high productivity of above-ground phytomass (3500–4500 kg/ha of absolutely dry matter) and productivity seeds (over 2000 kg/ha). Due to its rich biochemical composition (accumulates proteins, starch, vitamins, micro- and macroelements), it is actively used as a food, medicinal, fodder crop both in its homeland and almost all over the world.
Conclusions. Thus, plants of species of the genus Vigna are promising potential crops of the 21st century. Their high adaptive capacity to biotic and abiotic factors of the environment, productive potential testifies to their prospects for introduction and acclimatization throughout the world, the selection of resistant genotypes capable of effectively resisting the challenges of modern climate changes and preventing a possible food crisis.
Screening of promising potato hybrids by drought tolerance indices
Authors: Pysarenko N. V. , Sydorchuk V. I. , Zakharchuk N. A. , Hordiienko V. V.
Published: May 2023

Purpose. To evaluate promising potato hybrids for productivity and resistance to drought under water deficit conditions and to identify genotypes with a high level of adapta­bility to abiotic environmental factors.
Methods. During 2021–2022, 57 potato genotypes of different ripeness groups were studied in the fields of breeding crop rotation of the breeding laboratory of the Polissia Research Department of the Institute for Potato Research NAAS of Ukraine. Genera­l­ly accepted methods of selective statistical analysis were used.
Results. The research results revealed that in a dry year, the average potato yield loss for all maturity groups was 15.3 t/ha or 66 % compared to the indicators of a wet year. A high total percentage of drought-resistant and moderately drought-resistant hybrids was distinguished in the mid-season group. In total 16 breeding samples out of 54 studied ones under the condition of sufficient moisture produced the highest yield (in the range of 24.4–35.9 t/ha). During dry periods, 21 samples had high productivity (7.8–19.2 t/ha). The following hybrids showed an advantage over the average (Ŷ) for 8–9 evaluated drought tolerance indices: ‘P.15.56-10’, ‘P.17.21/43’, P.19.53/6’, ‘P.17.30-3’, ‘P.17.1-4’, ‘P.18.51/3’, ‘P.17.19-21’, ‘P.17.18/9’, ‘P.17.4/13’ ‘P.17.43/1’, P.17.44-1’, ‘P.17.38/16’, ‘P.17.8-28’, ‘P.17.13/7’ and ‘P.17.38-56’.
Conclusions. According to the results of the research, hybrids with high productivity and response to stress were identified. Thus, 5 samples formed high productivity under optimal conditions and were resistant to drought; 5 samples were flexi­b­le hybrids; 8 hybrids were demanding to moisture supply during the process of crop formation. The sources of drought resistance were 5 hybrids out of 54 studied ones. An average positive correlation (r = 0.528) between yields under diffe­rent moisture conditions was established.
Grain yield and protein content in different ripening varieties of soft winter wheat using various types and doses of fertilizers
Authors: Silifonov Т. V.
Published: May 2023

Purpose. To study of yield formation and protein content in the grain of different ripening varieties of soft winter wheat under the condition of using various types and doses of fertilizers.
Methods. Field and laboratory (determination of protein content), calculation (collection of protein), mathematical and statistical.
Results. It was found that different fertilization systems reliably increased the grain yield of soft winter wheat. The use of N75 increased this indicator by 1.2 times and N150 by 1.4 times in the varieties studied, compared with the no-fertilizer variant. Yield with incomplete return of phosphorus-potassium fertilizer was only 2–3% lower than with complete mineral fertilizer. With the nitrogen-phosphorus and nitrogen-potassium fertilization systems, the yield was 5–7% higher than with the nitrogen system. At the same time, this indicator was 6% lower than in the full mineral fertilizer version of the trial. The use of 75 kg/ha nitrogen fertilizer per year increased the protein content to 13.5%, or by 10% compared to the control. In the double dose nitrogen fertilizer variant, the protein content increased to 14.2% or by 15%. The use of nitrogen fertilizers with phosphorus-potassium only contributed 2–4% to the increase of this indicator. Cultivation of winter wheat under the condition of application of N75 increased the collection of protein up to 724 kg/ha or by 33%, and with a double dose of nitrogen fertilizer – up to 848 kg/ha or by 55% compared to the option without fertilizer. In the N75P30K40 variant, protein yield increased by 10% compared to the nitrogen system. The application of a complete mineral fertilizer (N150P60K40) increased this indicator by 12%.
Conclusions. It was found that the use of N75P30K40 increased the grain yield of soft winter wheat by up to 5.9 t/ha, or 7%, compared to the option where only 75 kg/ha of nitrogen fertilizer was applied. Yield development in soft winter wheat varies considerably from variety to variety. For example, this indicator was 35% higher in the ‘KWS Emil’ variety than in the ‘Prino’ line. In addition, the grain yield of both varieties is reliably influenced by the weather conditions during the growing season. The protein content of soft winter wheat varies considerably depending on the variety and the weather conditions. When growing soft winter wheat varieties, the protein content can vary by 12.8–15.1%. Weather conditions during the growing season can change this indicator by 13.1–14.7%. The protein content index in the grain of the ‘Prino’ line is significantly higher than that of the ‘KWS Emil’ variety. According to the protein yield per hectare indicator, the ‘KWS Emil’ variety (896 kg/ha) has a significant advantage over the ‘Prino’ line (774 kg/ha).
The results of the assessment of new varieties of Solanum tuberosum L. according to the main economic and valuable characteristics depending on the soil and climatic zones of cultivation
Authors: Mykhailyk S. M. , Kyienko Z. B. , Sonets T. D. , Smulska I. V.
Published: May 2023

Purpose. To carry out a comprehensive study and evaluation of new varieties of potatoes (Solanum tuberosum L.) according to the main economic and valuable indicators: yield, resistance to diseases and the content of starch and dry matter.
Methods. The qualification examination of potato varieties for suitability for distribution in Ukraine (PSP) is carried out throughout the territory of Ukraine within the soil and climate zones of the Forest Steppe and Polissia in accordance with the Methodology for the qualification examination of plant varieties for suitability for distribution in Ukraine (General part) and the Methodology for the examination of varieties potato plants and groups of vegetable, melon, spicy-tasty plants for their suitability for distribution in Ukraine.
Results. Economic and valuable characteristics of new potato varieties ‘Acoustic’, ‘Lady Amarilla’, ‘Sensation’, ‘Mia’, ‘Baltic Fire’, included in the State Register of plant varieties suitable for distribution in Ukraine (hereinafter – Register of varieties), were studied. An analysis of the varietal potential of potatoes was carried out based on the results of the qualification examination of the varieties. It was established that the yield of the stu­died potato varieties in all years of examination was higher in the forest-steppe zone and exceeded the yield obtained in the Polissia zone. In particular, the productivity of the varie­ty ‘Sensation’ by 29%, ‘Mia’ by 20%, ‘Lady Amarilla’ by 16%, ‘Baltic Fire’ by 19%, ‘Acoustic’ by 21%. Varieties ‘Sensation’ (24.3–33.8 t/ha) and ‘Acoustic’ (25.5–30.2 t/ha) produced the highest yield over the years of research. The varieties ‘Lady Amarilla’ and ‘Baltic Fire’ prevailed in terms of qua­lity indicators: the starch content in their tubers was 13.7–15.4% and 13.3–13.9%; dry matter content 22.2–23.2% and 21.5–22.0%, respectively. Disease and pest damage was generally average, with late blight causing the most dama­ge to crops in the Polissia zone.
Conclusions. Based on the results of the qualification examination, five positive expert opinions were prepared for the PSP. All studied varieties are recommended for growing in the Forest-Steppe and Polissia zones. Cancer-resistant potato varieties are proposed for introduction in disease foci and use as parental components and obtaining disease-resistant offspring. Cancer-resistant potato varieties are recommended to be grown in areas where the disease is likely to be detected and used in bree­ding to obtain new cancer-resistant varieties.
Twelve legal commandments for Russian surgeons
Authors: Zubkov D. S.
Published: May 2023

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Investigating the Mechanical Properties and Flexibility of N-BAR Domains
in PICK1 by Molecular Dynamics Simulations
Authors: Song Shenghan , Li Tongtong , Stevens Amy O. , Raad Taha , He Yi
Published: May 2023

Introduction:

The proteins of the Bin/Amphiphysin/Rvs167 (BAR) domain superfamily are
believed to induce membrane curvature. PICK1 is a distinctive protein that consists of both a BAR and
a PDZ domain, and it has been associated with numerous diseases. It is known to facilitate membrane
curvature during receptor-mediated endocytosis. In addition to understanding how the BAR domain
facilitates membrane curvature, it's particularly interesting to unravel the hidden links between the
structural and mechanical properties of the PICK1 BAR domain.

Methods:

This paper employs steered molecular dynamics (SMD) to investigate the mechanical properties
associated with structural changes in the PICK1 BAR domains.

Results:

Our findings suggest that not only do helix kinks assist in generating curvature of BAR domains,
but they may also provide the additional flexibility required to initiate the binding between
BAR domains and the membrane

Conclusion:

We have observed a complex interaction network within the BAR monomer and at the
binding interface of the two BAR monomers. This network is crucial for maintaining the mechanical
properties of the BAR dimer. Owing to this interaction network, the PICK1 BAR dimer exhibits different
responses to external forces applied in opposite directions.
Ultrasonographic Evaluation of Normal Liver, Spleen, and Kidney Dimensions
in a Healthy Turkish Community of Over 18 Years Old
Authors: Tiryaki Şaban , Aksu Yusuf
Published: May 2023

Background/Aims:

The dimensions of the liver, spleen, and kidneys either change in primary diseases related to these organs or in secondary diseases that indirectly affect them, such as diseases of the cardiovascular system. Therefore, we aimed to investigate the normal dimensions of the liver, kidneys, and spleen and their correlations with body mass index in healthy Turkish adults.

Material and Methods:

A total of 1,918 adults older than 18 years of age underwent ultrasonographic (USG) examinations. Participants’ age, sex, height, weight, BMI, liver, spleen, and kidney dimensions, biochemistry and haemogram results were recorded. The relationships between organ measurements and these parameters were examined.

Results:

A total of 1,918 patients participated in the study. Of these, 987 (51.5%) were female and 931 (48.5%) were male. The mean age of the patients was 40.74± 15.95 years. The liver length (LL) for men was found to be greater than that for women. The effect of the sex factor on the LL value was statistically significant (p = 0.000). The difference between men and women in terms of liver depth (LD) was statistically significant (p=0.004). The difference between BMI groups in terms of splenic length (SL) was not statistically significant (p=0.583). The difference between BMI groups in terms of splenic thickness (ST) was statistically significant (p=0.016).

Conclusion:

We obtained the mean normal standard values of the liver, spleen, and kidneys in a healthy Turkish adult population. Consequently, values exceeding those in our findings will guide clinicians in the diagnosis of organomegaly and will contribute to filling the gap in this regard.
Computer-aided Diagnosis Systems for Prostate Cancer: A Comprehensive
Study
Authors: Garg Gaurav
Published: May 2023

The American Cancer Society (ACS) reported in their Cancer Facts and Figures 2021 that prostate cancer (PCa) is the second leading cause of death among American men, with an average age of diagnosis being 66 years. This health issue predominantly affects older men and poses a significant challenge for radiologists, urologists, and oncologists when it comes to accurately diagnosing and treating it in a timely manner. Detecting PCa with precision and on time is crucial for proper treatment planning and reducing the increasing mortality rate. This paper focuses on a Computer-Aided Diagnosis (CADx) system, which is discussed in detail with different phases specific to PCa. Each phase of CADx is comprehensively analyzed and evaluated based on recent state-of-the-art techniques in both quantitative and qualitative aspects. This study outlines significant research gaps and findings for every phase of CADx, providing valuable insights to biomedical engineers and researchers.
An Insight into the Development of Potential Antidiabetic Agents along
with their Therapeutic Targets
Authors: Tiwari Siddhita , Kaur Paranjeet , Gupta Deepali , Chaudhury Saumik , Chaudhary Manish , Mittal Amit , Kumar Shubham , Sahu Sanjeev Kumar
Published: May 2023

Diabetes is a metabolic disorder that has been reported to increase the mortality rate worldwide. About 40 million people across the globe suffer from diabetes, with people living in developing countries being affected the most due to this deadly disease. Although the therapeutic management of hyperglycaemia can treat diabetes, metabolic disorders associated with this disease are a greater challenge in its treatment. Hence, potential strategies to treat hyperglycaemia and its side effects are needed. In this review, we have summarized several therapeutic targets, like dipep-tidyl peptidase-4 (DPP-4), glucagon receptor antagonists, glycogen phosphorylase or fructose-1,6-biphosphatase inhibitors, SGLT inhibitors, 11beta-HSD-1 inhibitors, glucocorticoids receptor an-tagonists, glucose-6-phosphatase and glycogen phosphorylase inhibitors. These targets can help in designing and developing novel antidiabetic agents.
A Review on Gastroprotective Mechanisms and their Augmentation by External
Agents
Authors: Sharma Poonam , Agarwal Shweta
Published: May 2023

The oral route is the most typical way to provide medication due to its benefits, including non-invasiveness, patient compliance, and ease of
medication delivery. One of the most often recommended pharmacological groups for the treatment of pain and inflammatory disease is nonsteroidal
anti-inflammatory medicines. However, the major side effect of non-steroidal anti-inflammatory medicines is PUD (peptic ulcer disease).
An imbalance in the action of gastroprotective and aggressive agents causes gastric ulcers. Gastroprotective mechanisms include the mucus layer,
mucosal repair capacity, gastric epithelium, and gastric blood flow. The purpose of this review is to provide an update on gastroprotective
mechanisms. As discussed, mucin acts as a filter, and gastric epithelial defenses include the cell barrier, stem cells, and a sensor on the mucosal
surface.
Autonomy and responsibility
Authors: Hong Le Thi Thu
Published: May 2023

This article presents solutions aimed at enhancing financial management in autonomous and accountable public universities in Vietnam. The study highlights the significance of autonomy and accountability in financial management to promote sustainable development and improve the quality of education. The proposed solutions encompass various aspects, including improving budgeting and financial planning, strengthening revenue management, enhancing expenditure management and rational utilization, reinforcing accounting, auditing, and oversight processes, and enhancing internal expenditure regulations. The research aims to provide practical recommendations that can be implemented to enhance financial governance in Vietnamese public universities, ultimately contributing to their long-term success and the advancement of education in the country.
Analysis of Groundwater Flow on Hydrogeological for Sustainable Development and Environment in the Ternate Basin, North Maluku Province, Indonesia
Authors: Daud Kadri
Published: May 2023

The sustainability of water and sanitation management is an important point in the 2021 SDGs program. To support the program, it is important to understand Indonesia's water cycle. Given the variety of characters, topography, and geology between islands in Indonesia can distinguish hydrogeological systems and their interactions with the surrounding environment. The design and management of water resources, especially groundwater, has an important role, considering the basin area is 106 km2, the character of a volcanic island with the name of an active volcano. Topography from 0-8% is a built-up zone, 8-14% is a cultivation zone, 14-45% is a protected forest, and >45% is a stratovolcano peak zone. Island morphology affects groundwater flow patterns. This study aimed to determine the characteristics of groundwater flow in the Ternate basin. Purposive sampling of 56 production wells, transmissivity value, conductivity, aquifer thickness, and topography was analyzed using the Cubic spline interpolation method. The results showed that the direction of flow and groundwater accumulation based on groundwater modeling using the kriging interpolation technique resulted in the interaction of groundwater flow and depression cones in 56 production wells due to the concentration and massive groundwater abstraction in the Ternate Basin. The decrease in groundwater level is fluctuating, from groundwater flows that occur radially-centrifugally, the total reserves of 56 production wells are 46 million m3/day, the average transmissivity value is 2.17 m2/day, production discharge is 51,710 m3/day.
Visualization in Anatomical Sciences for Effective Teaching and Learning
Authors: Pushpa Nagavalli Basavanna , Ravi Kumar Satish
Published: May 2023

Anatomy is one of the basic subjects of medical science. Medical students gain detailed knowledge of human body by dissecting cadavers. Hence, cadaveric dissection has become an essential tool in teaching and learning anatomy. In anatomy, visualization plays an important role in understanding the spatial orientation of structures. Due to technological advancement and a shortage of cadavers, there is a need to look for various complementary tools which can provide an adequate visualization of bodily structures. This issue was very well understood and reflected during the recent pandemic when cadaveric dissection was substituted by experimenting with various teaching tools. In this paper, we have tried to briefly describe the various options that can complement/supplement dissection and assist in self-directed learning.
Saving Lives Under Fire: The Extraordinary Efforts of ICU Health Professionals in the Ukrainian War
Authors: Kalia Raman , Kaur Charanjit , Kaur Amanpreet , Charan Gopal Singh
Published: May 2023

Amid the Ukrainian War, the heroes of the intensive care unit (ICU) - doctors, nurses, respiratory therapists, and many others - valiantly confront unprecedented challenges, showcasing resilience and dedication in the face of adversity. Despite limited resources and electricity backup issues, these health professionals worked tirelessly to provide life-saving care to critically ill patients, including those with gunshot wounds, shrapnel injuries, burns, and traumatic brain injuries. The article highlights the need to denounce attacks on medical personnel during conflicts, and strategies for supporting ICU health professionals in war zones are suggested, including hazard pay, comprehensive insurance coverage, safety training and equipment, support networks and mental health services, and ongoing education and professional development. The heroic efforts of ICU health professionals during times of war highlight the crucial role they play in healthcare systems worldwide.
The Relationship Between Eating Behaviors and Functional Status in Female Patients Diagnosed with Fibromyalgia
Authors: Mengi Alper
Published: May 2023

Aim. To evaluate whether eating behaviors of female patients with fibromyalgia syndrome differ from those of the healthy population, what factors affect these behaviors, and whether eating behaviors are effective on patients’ life quality and functional status.

Materials and Methods. This cross-sectional and observational study included 55 female fibromyalgia patients and 55 healthy female volunteers. All participants were assessed using demographic data, body mass index (BMI), and the Three-Factor Eating Questionnaire (TFEQ) (Uncontrolled Eating, Cognitive Restraint, Emotional Eating, and Hunger Susceptibility). Fibromyalgia patients were assessed using the Visual Analogue Scale (VAS) and Fibromyalgia Impact Questionnaire (FIQ).

Results. BMI, Uncontrolled Eating, and Hunger Susceptibility scores differed significantly between fibromyalgia patients and healthy volunteers (p < 0.05). In fibromyalgia patients, the TFEQ subscores were not correlated with the FIQ (p > 0.05). There was a positive correlation between the Cognitive Restraint score and age, rest and night pain scores in fibromyalgia patients (p< 0.05). Increasing age was an independent predictor of Cognitive Restraint in fibromyalgia patients (p=0.003).

Conclusions. The proportion of overweight/obese patients, BMI, Uncontrolled Eating, and Hunger Susceptibility were significantly higher among fibromyalgia patients. Fibromyalgia patients’ eating behaviors were not associated with their quality of life and functional status. Increasing age appeared to be a predictor of Cognitive Restraint degree.
Renin-Angiotensin System: A Review of Historical Perspectives
Authors: Kovalyova Olga , Zhuravlyova Anna , Ivanchenko Svitlana
Published: May 2023

The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the subsequent discoveries of angiotensin-converting enzyme 2, angiotensin- (1-7), Mas receptor.

This paper presents a modern classification of the renin-angiotensin system, dividing it into classical and non-classical branches, based on the determination of the biological effects of its components. Significant attention is devoted to elucidating the biochemical cascade of the renin-angiotensin system, its physiological transformations, and its implications in human body processes. The detrimental cardiac effects of the classical renin-angiotensin system are highlighted, along with the crucial role played by its alternative axis in counteracting the development of cardiovascular diseases.

The article presents data on the involvement of angiotensin-converting enzyme 2 and its receptors in coronavirus infections, susceptibility to infection, and disease progression.
“What IVC?”: Deep Vein Thrombosis in the Context of IVC Dysgenesis
Authors: Varkey Thomas C. , Merhavy Cheney E. , Ding Jack B. , Yost Kelli Kosako , Hyman Charles , Hancock Daphne , Garmer Caitlyn A. , Pyada Raaj , Nguyen Anne , Srivastava Arjun , Merhavy Zachary I.
Published: May 2023

Among young, otherwise healthy adults with unprovoked deep vein thrombosis (DVT), uncommon causes like variation in the normal sequential development of the inferior vena cava (IVC), must be explored. Anomalous IVC conditions are estimated to occur in up to 9% of the general population, with the rarest anomaly being IVC agenesis at 0.0005% - 1% general population prevalence. DVTs are more likely to develop in this population due to venous stasis from decreased venous return, even with the formation of extensive collateral veins. Herein, the authorial team presents a 22-year-old patient with leg pain and swelling who was found to have acute DVT, and, incidentally, the absence of the suprarenal IVC with a robust collateral system on further imaging studies. The morbidity of DVTs in this population is very high, and attention should be given to young patients who present with new-onset DVT in the setting of normal coagulation studies and lack of personal or family history of clotting disorders, as the need for specialized imaging such as venograms is necessary to secure the proper diagnosis.
ANALISIS PENERAPAN MODEL PEMBELAJARAN LOK-R TERHADAP KEMAMPUAN LITERASI SISWA DALAM PEMBELAJARAN SEJARAH
Authors: Dhesita Syela Joe
Published: May 2023

Pendidikan sebagai poros utama lahirnya sebuah peradaban harus berinovasi dalam menghadapi tantangan pendidikan abad 21. Pendidikan abad 21 diharapkan dapat melahirkan generasi yang memiliki inovasi dan ketrampilan belajar. Mampu menggunakan dan mengakses media informasi serta dapat bekerja dan menggunakan ketrampilannya untuk bertahan hidup atau memiliki life skills. Rendahnya kemampuan Literasi menjadi permasalah uama bangsa Indonesia dalam menjawab tantangan pendidikan abad 21. Guru sebagai sendi utama pendidikan harus turut mengambil epran dalam perubahan ini, sala satunya adalah dengan melakukan inovasi model pembelajaran. Dalam penelitian ini inovasi yang ditawarkan adalah model pembelajaran LOK-R sebagai solusi peningkatan kemampuan literasi sejarah dalam pembelajaran sejarah di sekolah menengah atas. Penelitian ini menggunakan metode kualitatif deskriptif dengan pendekatan studi kasus pada siswa kelas XI IPS 1 MAN Sukoharjo, Jawa tengah. Teknik pengumpulan data adalah studi literatur, wawancara dan observasi. Berdasarkan hasil analisis diketahui bahwa Model pembelajaran LOK-R dapat digunakan menjadi salah satu solusi dalam meningkatkan literasi sejarah peserta didik dalam pembelajaran sejarah. Hal ini dikarenakan model pembelajaran ini telah memanfaatkan pembelajaran berbasis literasi dimana bertujuan untuk mengembangkan kemampuan siswa dalam memahami teks dan mengaitkannya dengan pengalaman pribadi sehingga terbentuk pribadi pembelajar sepanjang hayat. Selain itu proses pembelajaran yang dilakukan dengan tahapan Literasi, Orientasi, Kolaborasi, dan refleksi ini mendorong peserta didik untuk berpikir kritis hingga pada akhirnya siswa memiliki kemampuan mengelolah informasi dan berkomunikasi secara kreatif baik verbal maupun tulisan, bahkan digital dan visual. Harapannya diterapkannya pembelajaran LOK-R pada pelajaran sejarah dapat melahirkan generasi mud ayng memiliki kepekaan social dan tidak skeptis terhadap perkembangan bangsa hingga akhirnya dapat berperan aktif dalam persaingan global secara positif.Key Word : Model Pembelajaran LOK-R, Litersi Sejarah, Inovasi Pendidikan
LEARNING MATERIALS INNOVATION IN THE CONTEMPORARY HISTORY OF THE WORLD WITH LOCAL HISTORY
Authors: Saputro Pradata Ardi
Published: May 2023

Education has developed along with the progress of the times. Efforts are needed to improve the quality of education at this time. Teachers as central figures in the learning process must be able to improve their quality in teaching and learning activities. Learning innovation in the learning process needs to be done to realize quality education. With learning innovations, it can create a conducive atmosphere in teaching and learning activities so that students can gain knowledge to the fullest. Learning material is one of the important elements in the learning process. Materials related to local history will attract students' attention and interest to learn history. This study aims to innovate material in history learning in high school in order to increase student interest in learning. This is motivated by the declining interest of students in studying history, especially in contemporary world history material. Low interest in learning will affect the achievement of learning objectives. The method used in this research is qualitative research by combining the results of interviews with the study of documents relevant to this research. The results of this study are (1) Knowing history learning in high school, (2) Knowing the background of students feeling bored with history learning, (3) Knowing that material innovation in contemporary world history materials can increase students' interest in learning.
THE INFLUENCE OF TECHNOLOGY-BASED MEDIA OF DIGITAL JAVANESE SCRIPT AMONG JUNIOR HIGH SCHOOL STUDENTS
Authors: Fajrin Hilma Oktaviana
Published: May 2023

The impact of advances in digital technology has eroded the existence of the Javanese language as one of the regional languages used in Indonesia. The Javanese Script, an important component of the Javanese language, is less attractive to the younger generation. Digital literacy can be used to develop culture because it fits the characteristics of the current generation as digital natives. Now, people can write Javanese scripts using a computer because the Javanese Script has been successfully included in the digital standard writing system (Unicode) since 2009. This is also utilised by developing a Javanese script keyboard called Aksaraya which can be installed on the IPad. The method chosen in this research is quasi-experimental. It was carried out by giving treatment with Aksaraya media to reveal its influence through a pretest-posttest control group design experimental design. The analysis in this study is the Paired sample T-Test with the help of SPSS 21 for windows. In this study, the population used was SMP Negeri 4 Pakem, while the sample taken was the eighth-grade students. Their conceptual understanding of data is gained from tests conducted before and after using digital-based Javanese script learning media. The analysis showed that the students' mean scores after using digital-based Javanese writing learning media were higher (80.05) than before (60.96). It showed the correlations (0.670) that indicated a strong relationship with Sig. (0.000) ˂ α = 0.05. It can be concluded that Aksaraya learning media significantly influences students' learning results.
IMPLEMENTASI KEPEMIMPINAN KEPALA SEKOLAH DALAM MENINGKATKAN KOMPETENSI GURU SD NEGERI SE KECAMATAN MERGANGSAN YOGYAKARTA
Authors: Suprapti Suprapti
Published: May 2023

Kepemimpinan kepala sekolah dalam usahanya membantu meningkatkan kompetensi para guru se wilayah Kecamatan Mergangsan belum ada informasi seberapa besar peranannya. Tujuan penelitian ini adalah untuk mengetahui kepemimpinan yang dilaksanakan oleh kepala sekolah SD Negeri se Kecamatan Mergangsan Kota Yogyakarta dalam meningkatkan kompetensi kepribadian guru, kompetensi pedagogi guru, kompetensi profesional guru dan kompetensi sosial guru. Jenis penelitian deskriptif kuantitatif dengan pendekatansurvei. Penelitian ini dilakukan di SD Negeri se Kecamatan Mergangsan Kota Yogyakarta. Subjek penelitian ini berjumlah 76 orang guru yang berasal dari 7 SD Negeri di wilayah Kecamatan Mergangsan. Instrumen yang digunakan dalam penlitian ini adalah angket dan pedoman wawancara. Dalam penelitian ini teknik analisis data menggunakan teknik analisis deskriptif. Hasil penelitian ini menyimpulkan bahwa:(1) secara umum kepemimpinan kepala sekolah dalam meningkatkan  kompetensi guru Sekolah Dasar Negeri se Kecamatan Mergangsan baik sekali. Peningkatan kompetensi guru ini melalui peningkatan kompetensi kepribadian, kompetensi pedagogi, kompetensi profesional dan kompetensi sosial. (2) berdasarkan faktor-faktor yang ada, kepemimpinan kepala sekolah dalam meningkatkan kompetensi guru Sekolah Dasar Negeri se Kecamatan Mergangsan adalah: (a) kompetensi kepribadian dalam kategori baik sekali. Peningkatan kompetensi kepribadian ini dilakukan melalui pengembangan prilaku sopan santun, pengembangan kewibawaan guru, dan meningkatkan ketaqwaan guru, (b) kompetensi pedagogi dalam kategori baik sekali. Peningkatan kompetensi pedagogi ini dilakukan melalui penyiapan perencanaan pembelajaran, perbaikan proses pembelajaran dan melakukan perbaikan evalusi pembelajaran, (c) kompetensi profesional dalam kategori baik sekali. Peningkatan kompetensi profesional ini dilakukan melalui peningkatan penguasaan materi dan menambah ilmu pengetahuan, (d) kompetensi sosial dalam kategori baik sekali. Peningkatan kompetensi sosial ini dilakukan melalui usaha mempererat hubungan baik dengan siswa, mempererat hubungan baik dengan sesama guru, dan mempererat hubungan baik dengan wali murid.
PENINGKATAN SIKAP, KETERAMPILAN, DAN HASIL BELAJAR IPS MELALUI PEMBELAJARAN OBSERVASI
Authors: Sulino Sulino
Published: May 2023

Kegiatan pembelajaran IPS pada SMP Negeri I Karangmojo cenderung teacher centered. Guru lebih banyak aktif menyampaikan materi pelajaran, sedangkan peserta didik pasif menerima materi pelajaran. penelitian ini bertujuan untuk meningkatkan hasil belajar peserta didik pada materi dampak aktivitas manusia terhadap lingkungan sekitar. Di samping itu penelitian tindakan kelas ini juga bertujuan untuk mengetahui sikap peserta didik dengan indikator kedisiplinan, kerjasama, kejujuran, dan tanggung jawab pada saat mengikuti proses pembelajaran, serta keterampilan peserta didik berupa kemampuan presentasi dalam menyampaikan hasil pembelajaran di depan kelas. Penelitian ini menggunakan model pembelajaran observasi yang diterapkan pada penelitian tindakan kelas. Subyek penelitian adalah peserta didik kelas VII.C pada SMP Negeri I Karangmojo tahun pelajaran 2021/2022. Data dikumpulkan dengan menggunakan teknik observasi, dan tes hasil belajar peserta didik. Data dianalisis berdasarkan hasil observasi dan tes hasil belajar yang diperoleh di akhir di setiap siklus. Hasil penelitian menunjukkan bahwa penggunaan model pembelajaran observasi dilihat dari aspek kedisiplinan, kerjasama, kejujuran, dan tanggung jawab peserta didik pada saat mengikuti proses pembelajaran serta kemampuan presentasi peserta didik dalam menyampaikan hasil pembelajaran di depan kelas cukup baik, secara kuantitatif rata-rata 80,4. Sedangkan hasil belajar peserta didik melalui tes juga menunjukkan ketuntasan belajar meningkat signifikan dari 21,4% sebelum menggunakan model observasi menjadi 85,7%.
PERAN ETNIS TIONGHOA DALAM PEMBANGUNAN JALUR KERETA API BATAVIA-PARAHYANGAN TAHUN 1869-1884
Authors: Agustin Rizki Dwi , Maryuni Yuni , Fauzan Rikza
Published: May 2023

Penelitian ini bertujuan untuk memaparkan peran etnis Tionghoa dalam pembangunan jalur kereta api tahun 1869-1884. Metode yang digunakan dalam penelitian ini adalah metode sejarah yang terdiri dari heuristik, kritik, interpretasi, dan historiografi dengan menggunakan pendekatan politik ekonomi. Berdasarkan hasil penelitian terungkap bahwa pembangunan jalur kereta api dari Batavia menuju Parahyangan dimulai pada tanggal 15 Oktober 1869 dan selesai serta diresmikannya stasiun Bandung pada tanggal 17 Mei 1884. Total panjang jalur kereta api dari Batavia menuju Parahyangan berjumlah 182.5 KM. Motif yang melatarbelakangi etnis Tionghoa dalam pembangunan jalur kereta api Batavia-Parahyangan terbagi menjadi dua, yang pertama sebagai kuli dan yang kedua sebagai pemborong. Etnis Tionghoa mau melibatkan diri dalam pembangunan jalur kereta api sebagai kuli karena upah yang didapatkan lebih banyak ketimbang jenis pekerjaan yang sama di tempat lain. Upah yang didapatkan sebagai kuli dalam pembangunan kereta api berkisar antara f1,50-f2,00. Sedangkan dalam pekerjaan lain berkisar antara f0,20-f1,00. Selain sebagai kuli, etnis Tionghoa juga memiliki peran sebagai pemborong. Kebutuhan material untuk pembangunan jalur kereta api Batavia-Parahyangan seperti batu, semen dan yang lainnya banyak didapatkan oleh pemerintah Belanda dari etnis Tionghoa. Dampak sosial ekonomi etnis Tionghoa dalam pembangunan jalur kereta api Batavia hingga Parahyangan adalah mobilitas penduduk yang tinggi menimbulkan banyak pusat keramaian yang dimanfaatkan untuk berwirausaha oleh etnis Tionghoa. Selain itu, dampak lainnya yang timbul adalah akulturasi budaya masyarakat pribumi dengan etnis Tionghoa. Akulturasi ini terjadi bermula dalam penyediaan tenaga kerja kasar atau kuli. Karena dikerjakan bersamaan, maka para pekerja Tionghoa ini berbaur dengan orang-orang pribumi dan terjadilah proses akulturasi.
Why Do Students Plagiarise? An empirical study on Built Environment Students Amidst Covid-19
Authors: Ahmad Zaini Afzan , Wahid Julaihi , Gui Hun Chuen , Tookey John
Published: May 2023

Plagiarism has been battering higher education since the onset of the Covid-19 pandemic. Hence, this research aimed to develop a model to elucidate the types, reasons and strategies to mitigate Plagiarism and misconduct in online examinations. The instrument employed for this research was an online questionnaire, and the study population was determined to be built environment students from five institutions of higher learning. A total of 308 survey forms were analysed using factor analysis, structural equation modelling (SEM) and content analysis. In addition, sixteen (16) case studies were presented and examined to validate the findings.
A Comparative Study of Female Retirement Awareness and Readiness in Malaysia and China
Authors: Yuan Jing , Chong Kim Mee , Hii Ivy Siaw Hung , Li Hao Lun
Published: May 2023

A phenomenon has emerged whereby the life expectancy of women is 74.2 years, and men's is 69.8 years. Hence, it is crucial to encourage early retirement planning among women. This study explores the factors influencing retirement planning awareness and readiness among women in Malaysia and China. 100 Malaysians and 200 Chinese completed a self-administered online questionnaire. Using IBM SPSS and SmartPLS, the determinants examined the moderating effect of self-efficacy toward retirement readiness. This study will provide valuable insights for policymakers to adopt better strategies to address women's issues and improve their quality of life.
Sustaining Students’ Quality Learning Environment by Reviewing Factors to Graduate-on-Time: A case study
Authors: Sidhu Gurnam Kaur , Kannan Sathiamoorthy , Arieff Shamida  , Du Ruofei
Published: May 2023

Research reveals that several factors affect the quality of learning environments. Therefore, this study investigated significant factors that affect postgraduate students’ learning environment with regard to graduate on time (GOT). The study was conducted in a private Malaysian university involving 50 PhD students. Data were collected via tests, a questionnaire, and focus-group interviews. The findings revealed that critical reading skills and supervisory factors were significant factors affecting students’ ability to GOT. This implies that universities should integrate early intervention training programs to hone students’ critical literacy skills and provide effective supervisory practices for a sustainable quality postgraduate learning environment.
Concept and Factors affecting Well-Being as Perceived by Bangkok Homebuyers
Authors: Wongpakdee Sumitra , Nanta Piyarat , Kutintara Benjamas
Published: May 2023

This exploratory study aims to: [1] explore how the Bangkok home buyers define the notion of well-being and [2] identify the built environment and socioeconomic attributes that the home buyers perceived as factors contributing to the state of well-being. Research data is collected from thirteen focus group discussions. Results from this research indicated that the informants perceived well-being as a highly positive feeling derived from having good physical and mental health. Factors contributing to well-being included living in a good environment and friendly community, encompassing a comfortable and convenient lifestyle, safety, and appealing built environment design.
Privacy and Relationships of Roommates in the Situation of Covid 19
Authors: Sanpaychudayan Paramita , Kutintara Benjamas
Published: May 2023

The lack of privacy affected the student roommates' relationships. This study investigates the relationship between privacy and roommates' relationships in the COVID-19 situation and investigates the relationship between sensitivity to the lack of privacy and relationship status among roommates during COVID-19. Data was collected by behavioral traces in 4 bedrooms, conducting interviews and focus group discussions with eight students, and distributing questionnaires to 61 students. Findings found that in COVID-19, half of the sample felt more negatively about their privacy being disturbed. Privacy and relationships were positively correlated, and relationship status did not affect sensitivity to the lack of privacy.
Student Learning Engagement with Emerging Technologies in the EFL Classroom in China: A Case Study
Authors: Fan Min , Gurnam Kaur Sidhu  , Khor Melanie , Jiang Huaying
Published: May 2023

This study investigated learner engagement with emerging technologies as a viable teaching and learning tool. This explorative study was conducted in a public university located in Sichuan Province, China involving 160 sophomore students. Data were collected via a questionnaire consisting of open and close-ended questions. The findings revealed that EFL students frequently used Tencent as the preferred platform for online distance learning. Besides that, the findings demonstrated students' positive perception of learner-to-learner, learner-to-instructor, and learner-to-content interaction through the support of emerging technologies. Thus, it implies that emerging technologies have the potential to boost a quality learning environment.