bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of carbon on whole-biofilm metabolic response to high doses of streptomycin
Authors: Jackson Lindsay M.D. , Kroukamp Otini , Wolfaardt Gideon
Published: February 2023

Biofilms typically exist as complex communities comprising multiple species with the ability to adapt to a variety of harsh conditions. In clinical settings, antibiotic treatments based on planktonic susceptibility tests are often ineffective against biofilm infections. Using a CO2 evolution measurement system we delineated the real-time metabolic response in continuous flow biofilms to streptomycin doses much greater than their planktonic susceptibilities. Stable biofilms from a multispecies culture (containing mainly Pseudomonas aeruginosa and Stenotrophomonas maltophilia), Gram-negative environmental isolates, and biofilms formed by pure culture P. aeruginosa strains PAO1 and PAO1 ΔMexXY (minimum planktonic inhibitory concentrations between 1.5 and 3.5 mg/l), were exposed in separate experiments to 4000 mg/l streptomycin for 4 h after which growth medium resumed. In complex medium, early steady state multispecies biofilms were susceptible to streptomycin exposure, inferred by a cessation of CO2 production. However, multispecies biofilms survived high dose exposures when there was extra carbon in the antibiotic medium, or when they were grown in defined citrate medium. The environmental isolates and PAO1 biofilms showed similar metabolic profiles in response to streptomycin; ceasing CO2 production after initial exposure, with CO2 levels dropping toward baseline levels prior to recovery back to steady state levels, while subsequent antibiotic exposure elicited increased CO2 output. Monitoring biofilm metabolic response in real-time allowed exploration of conditions resulting in vulnerability after antibiotic exposure compared to the resistance displayed following subsequent exposures.
“Distract parcels in combined sums”: The Stratford Festival Archives' Stage-Managerial Collections
Authors: Malone Toby
Published: February 2023

The Stratford Festival Archives houses the largest single-theatre archive in the world, spanning more than sixty years of performing history, artefacts, production materials, and ephemera. Uniquely, the Stratford Archives also hosts a growing collection of palimpsestic composite scripts, layered master texts which feature every dramaturgical cut in the Festival's history. Through consideration of Festival prompt-books and composite scripts, this paper illustrates Stratford’s approach to stage-managerial material, with particular focus on the industry of archivist Nora Polley. Featuring a collection of high-quality prompt-book scans, this paper examines the efficacy of composite prompt-books, both as a practical dramaturgical tool and effective work of ongoing archival memorialization.
Мethod of Narrow Fractions Complex Analysis of the Contemporary Oil Refinery
Authors:   LLC “Lukoil-Nizhegorodorgsintez”, Karpov A. N. , Fadeev V. V. ,   LLC «RN-RD CENTER», Rudyak K. B. ,   LLC «RN-RD CENTER», Maksimov A. L. ,   A. V. Topchiev Institute of Petrochemical Synthesis, RAS, Chernysheva E. A. ,   Gubkin Russian State University of Oil and Gas, Tarasov A.V. ,   Yaroslavl State Technical University, Tarusov D. V. ,   Slavneft-YANOS PJSC, Ivanov P. S. ,   Slavneft-YANOS PJSC, Dutlov E. V. ,   Slavneft-YANOS PJSC, Vakhromov N. N. ,   Slavneft-YANOS PJSC, Bubnov M. A. ,   Slavneft-YANOS PJSC, Gudkevich I. V. ,   Slavneft-YANOS PJSC, Borisanov D. V. ,   Slavneft-YANOS PJSC
Published: February 2023

The existing methods to assess the quality of feed for obtaining various petroleum products from it are described.An algorithm for narrow fractions complex analysis of refinery flows is proposed, which makes it possible to determine the optimal ways for their further processing or involvement in commercial products. An application methodfor this algorithm is given. Examples of the method application for the formation of an optimized feedfor the diesel fuel isodewaxing unit, when obtaining hydrocarbon base for drilling fluids, and assessing the origin of mercaptans contained in straight-run jet fuel fractions are given.
Family Kinship and its Impact on Age and Livelihood Based on the Sunnah of the Prophet
Authors: Foda Eman Abdel Aziz Al-Sayed
Published: February 2023

Kinship ties is not only amongst the greatest acts of worship and obedience, but it is also a permanent and indefinite duty, and severing ties of kinship is a major sin, and it means Kindness to the relatives by doing whatever achieve the relation as much as possible by Al-Wasil, whether by money, visiting, or by asking about them, or with the participation in their events, to other licit relation, and the research has dealt with the extent of the Prophet's Sunnah interest of Kinship ties and its impact on longevity and extension in sustenance. This appears in many Hadeeths, and through this study the researcher reached many of the following conclusions and recommendations: that Kinship ties is an obligation and severing it is a major sin and that it has degrees, some are higher than others, and the lowest is achieved by leaving abandonment, the more the relationship is confirmed, and its attachment, and that Kinship ties prolong life and expand in the sustenance, whether this increase is real or a moral increase, and Kinship ties has many virtues, and many impacts on the individual and society, and the one who break it, His punishment is severe in this world and the Hereafter.
Análisis del discurso con perspectiva de género de los textos narrativos incluidos en los libros de texto gratuito del primer ciclo de educación primaria
Authors: Hernández Gaspar Marilu
Published: February 2023

La presente investigación tiene por objeto de estudio el discurso en los textos narrativos incluidos en los libros de texto gratuito (LTG) del primer ciclo de educación primaria. Basada en el método de análisis del discurso, se sigue una línea de interpretación propia de la investigación cualitativa. El análisis del discurso propicia la interpretación de textos y el uso del lenguaje humano, se convierte pues en una herramienta para la reformulación de concepciones dominantes dentro del ámbito educativo. Para fines de esta investigación se confronta el discurso de los textos con la perspectiva de género. Dichos textos se eligen de los libros de lengua materna, donde se encuentra el mayor concentrado de lecturas narrativas; primero se realiza la revisión teórica de género y perspectiva de género, que son el punto clave de esta investigación; posteriormente se hace la selección del material y análisis del discurso en los cuentos para determinar el tipo de ideología que transmiten y reconocer si estos reproducen o no desigualdad social respecto al género. Se realiza un análisis de manera general de las intenciones o sentido de los textos seleccionados, mostrando qué tipo de discurso plantean, sin embargo, por el tipo de investigación, parcial, no se llega al estudio semántico del texto de manera profunda, pero se encuentran hallazgos que hacen notoria la reproducción del orden social dentro de los textos.
TEKS MANTRA SRI POHACI PADA TRADISI DI KAMPUNG CIPICUNG: SEBUAH ANALISIS STRUKTURAL
Authors: Dede Dede rifadah , Firdaus Asep
Published: February 2023

Mayoritas masyarakat di Kampung Cipicung, Desa Kertaangsana, Kecamatan Nyalindung, Kabupaten Sukabumi masih mengikuti kebiasaan masyarakat terdahulu yang diwariskan dari nenek moyangnya, yaitu bertani. Ada beberapa tahap ritual upacara pada saat sebelum proses penanaman padi hingga selesai panen, salah satunya yaitu pembacaan mantra pada saat ritual tertentu (ketika menanam padi). Mantra tersebut di kampung Cipicung dikenal dengan nama mantra Sri Pohaci. Tujuan dari penelitian ini adalah untuk mengetahui struktur teks mantra Sri Pohaci pada Tradisi Sangar masyarakat Kampung Cipicung. Metode yang digunakan dalam penelitian ini menggunakan metode penelitian kualitatif deskriptif. Teknik pengumpulan data dilakukan, dengan wawancara, observasi, dan pencatatan dilakukan dalam upaya mengalihbahasakan teks mantra dari lisan menjadi bentuk tulisan, strategi penelitian yang digunakan dalam penelitian ini adalah penelitian etnografi untuk mendapatkan deskripsi tentang jalannya tradisi Sangar dan pembacaan mantra Sri Pohaci. Ada enam mantra dalam mantra sri pohaci, mantra ngukus, mantra tandur , mantra nyawen, mantra mitemeyan, mantra babak salira dan mantra pertobat, Struktur mantra sripohaci, terdiri dari unsur judul, unsur pembuka, unsur sugesti dan unsur tujuan.
UPAYA MENINGKATKAN PEMAHAMAN PESERTA DIDIK PADA MATERI CARITA PONDOK MELALUI MODEL PEMBELAJARAN PROBLEM BASED LEARNING
Authors: Yuanita Tika , Nurhayati Lestari Tika
Published: February 2023

Penelitian ini bertujuan untuk mengetahui bagaimana upaya meningkatkan pemahaman peserta didik pada materi carita pondok melalui model pembelajaran problem based learning. Metode penelitian yang digunakan adalah penelitian tindakan kelas (PTK). Metode ini dilakukan melalui 4 tahapan, yakni perencanaan, pelaksanaan, pengamatan dan refleksi. Instrumen yang digunakan adalah lembar observasi peserta didik, instrumen tes, dan catatan lapangan. Hasil Penelitian menunjukkan bahwa nilai rata-rata hasil tes pemahaman peserta didik diakhir siklus I adalah 62, kemudian meningkat menjadi 74 di akhir siklus II. Sedangkan persentase aktivitas peserta didik mengalami peningkatan, yakni dari siklus I 63,35% dan di siklus II menjadi 82,13%. Dengan demikian dapat disimpulkan bahwa penggunaan model  pembelajaran problem based learning dapat meningkatkan pemahaman peserta didik pada materi
PENERAPAN HIPNOTERAPI TERHADAP KECEMASAN BELAJAR MATEMATIKA DENGAN PEMBELAJARAN JARAK JAUH
Authors: Suryaman Oman , Ricki Yuliardi  , Agus Saeful Anwar
Published: February 2023

Tujuan penelitian ini adalah agar siswa tidak mengganggap bahwa pelajaran Matematika merupakan mata pelajaran yang tidak menyenangkan, yang meninmbulkan kecemasan dan bahkan ada rasa takut bagi siswa setiap akan bertemu dengan pembelajaran matematika. Metode penelitian ini menggunakan penelitian kuantitatif dengan metode eksperimen dengan design penelitian one group pretest-postest, design. Populasi dalam penelitian adalah siswa SDN Sukamulya 2 yang berjumlah 20 orang, dengan sampel 10 orang. Penelitian ini adalah untuk membuktikan secara empiris penerapan hipnoterapi terhadap gangguan kecemasan. Penelitian ini penting untuk dilaksanakan karena dapat dijadikan bahan pertimbangan dalam proses penyembuhan gangguan kecemasan bagi para terapis. Penelitian ini menggunakan penelitian eksperimen. Data penelitian didapat dari observasi, wawancara dan kuesioner. Pada teknik observasi, peneliti datang untuk mengamati proses pembelajaran. Selanjutnya peneliti melakukan wawancara dan memberikan kuesioner pada siswa. Penelitian dilakukan dengan cara memberikan terapi hipnoterapi pada siswa. Data diperoleh dari pretest dan posttest. Hasil penelitian ini adalah ada pengaruh yang signifikan penerapan hipnoterapi terhadap penurunan gangguan kecemasan pada Peserta didik (siswa) SD Negeri 2 Sukamulya khusunya kelas 5. Hal ini dibuktikan dari hasil penghitungan tes akhir kelompok penerapan hipnoterapi yaitu thitung = 49.3978 lebih besar dari pada ttabel = 2.145 dengan taraf signifikasi 5%.
KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS PADA MATERI STATISTIKA SISWA SMK KELAS 12
Authors: Sari Ismi Novita , Warmi Attin
Published: February 2023

Tujuan dari penelitian ini untuk mendeskripsikan kemampuan pemahaman konsep matematis siswa SMK kelas 12 di Karawang pada materi statistika dengan indikator dari kilpatrickyaitu 1) Mampu menyatakan kembali sebuah konsep; 2) Memberikan contoh dan non contoh sebuah konsep; 3) Mampu mengembangkan syarat konsep; 4) Mampu menggunakan prosedur yang tepat; 5) Mampu mengaplikasikan konsep pemecahan masalah. Metode penelitian yang saya gunakan adalah metode deskriptif kualitatif. Subjek dari penelitian ini terdiri dari 3 orang siswa kelas 12 yang kemudian digolongkan kedalam kategori subjek dengan kemampuan tinggi, subjek berkemampuan sedang, dan subjek berkemampuan rendah. Penelitian ini menggunakan instrumen uji berupa soal tes berbentuk kuis dengan 2 jenis soal, yakni soal pengetahuan konsep dan hitungan yang dapat menguji pemahaman matematis siswa. Hasil dari penelitian menunjukkan bahwa 1) subjek dengan kategori tinggi sudah mampu memenuhi indikator indikator kemampuan pemahaman konsep matematis siswa menurut Kilpatrick; 2) subjek dengan kemampuan sedang sudah mampu memenuhi sebagian besar indikator indicator menurut Kilpatrick; 3) subjek dengan kemampuan rendah hanya mampu menyajikan definisi statistika dan membedakan contoh dan noncontoh statistika pada sesi tanya jawab.
PENERAPAN MODEL EXPERIENTIAL LEARNING BERBASIS ETNOMATEMATIKA TERHADAP KEMAMPUAN BERPIKIR KREATIF MATEMATIS SISWA
Authors: Sari Sari , Wahyuni Rika , Prihatiningtyas Nindy Citroresmi
Published: February 2023

Penelitian ini bertujuan untuk: (1) Mengetahui perbedaan kemampuan berpikir kreatif matematis siswa antara kelas yang diterapkan model experiential learning berbasis etnomatematika dengan kelas yang diterapkan model pembelajaran langsung pada materi bangun ruang sisi datar MTs Al-Fatah Singkawang, (2) Mengetahui bagaimana aktivitas belajar siswa ketika diterapkan pembelajaran dengan menggunakan model experiential learning berbasis etnomatematika pada materi bangun ruang sisi datar, (3) Mengetahui bagaimana minat belajar siswa terhdap pembelajaran matematika dengan menggunakan model experiential learning berbasis etnomatematika pada materi bangun ruang sisi datar. Metode penelitian yang digunakan adalah metode eksperimen dengan model experiential learning berbasis etnomatematika. Penelitian ini dilaksanakan di MTs Al-Fatah Singkawang pada siswa kelas VIII. Instumen pengumpulan data yang digunakan berupa soal tes kemampuan berpikir kreatif matematis siswa, lembar observasi aktivitas siswa, dan angket minat belajar siswa. Hasil penelitian menunjukkan bahwa: (1) Terdapat perbedaan kemampuan berpikir kreatif matematis siswa yang menggunakan model experiential learning berbasis etnomatematika dengan model pembelajaran langsung pada materi bangun ruang sisi datar, (2) Aktivitas belajar siswa tergolong aktif sesudah diterapkannya pembelajaran model experiential learning berbasis etnomatematika pada materi bangun ruang sisi datar di MTs Al-Fatah Singkawang, (3) Minat belajar siswa tergolong tinggi jika diterapkannya model experiential learning berbasis etnomatematika pada materi bangun ruang sisi datar di MTs Al-Fatah Singkawang.
MENINGKATKAN KEMAMPUAN KOMUNIKASI MATEMATIS SISWA DENGAN PERAPAN STRATEGI LEARNING WITH QUIS TEAM
Authors: Gumilar Agung Cahya , Lia Yuliantika  , Puji Budilestari
Published: February 2023

Penelitian ini berjudul “Meningkatkan kemampuan komunikasi matematis siswa dengan penerapan strategi learning with quiz team”. Kemampuan komunikasi matematis siswa merupakan salah satu dari keampuan siswa yang harus dikembangkan dan sesudah proses pembelajaran. Hal ini karena melalui kemempuan komunikasi matematis siswa dapat mengorganisasikan berpikir matematis siswa secara lisan maupun tulisan. Salah satu untuk meningkatkan kemampuan komunikasi matematis siswa dengan penerapan strategi learning with quiz team. Penelitian ini bertujuan untuk mengetahui kemampuan komunikasi matematis siswa yang mendapatkan penerapan strategi learning with quiz team lebih baik dari siswa yang mendapatkan pembelajaran konvensional. Penelitian ini menggunakan metode eksperimen dengan sifat penelitian kuantitatif dan kualitatif. Populasi penelitian ini adalah seluruh siswa kelas VII SMPN 3 Purwadadi dan sampel dari penelitian ini diambil dua kelas yaitu kelas VII F dan VII C. Instrumen yang digunakan dalam penelitian ini adalah lembar observasi dan tes kemampuan komunikasi matematis siswa terhadap pembelajaran yang menggunakan strategi learning with quiz team. Berdasarkan analisis data hasil penelitian menggunakan SPSS V.23 for windows, bahwa 1) Proses pembelajaran strategi learning quiz team dapat terlaksana dengan sangat baik. 2) Terdapat peningkatan kemampuan komunikasi matematis tertulis siswa setelah diterapkan strategi learrning with quiz team. 3) Terdapat peningkatan kemampuan komunikasi matematis lisan siswa setelah diterapkan strategi learrning with quiz team. 4) Kemampuan komunikasi matematis tertulis siswa yang pembelajarannya menggunakan strategi learning with quiz team lebih baik daripada kemampuan komunikasi matematis tertulis siswa yang belajar menggunakan pembelajaran konvensional.5) Kemampuan komunikasi matematis tertulis siswa yang pembelajarannya menggunakan strategi learning with quiz team lebih baik daripada kemampuan komunikasi matematis lisan siswa yang belajar menggunakan pembelajaran konvensional.
PENERAPAN KOMUNIKASI TERAPEUTIK DALAM PELAYANAN KESEHATAN
Authors: Sari Ayu , Saragih Rasianna
Published: February 2023

Tujuan penelitian ini adalah mendeskripsikan penerapan komunikasi terapeutik yang terjadi antaradokter spesialis Obstetri dan Ginekologi dengan pasien ibu hamil di Apotek Al-Khair Bengkulu.denganpendekatan kualitatif yang bersifat deskriptif. Objek penelitian ini adalah bentuk komunikasi terapeutikdalam pelayann kesehatan Apotek Al-Khair Bengkulu. Sumber data penelitian ini adalah Dokter SpesialisObgyn di Apotek Al-Khair Bengkulu, dengan model analisis interaktif (interactive models of analysis).Hasil peneltian menunjukan bahwa: (1) Komunikasi terapeutik diperlukan selama proses interaksi dananamnesis (2) Dari 16 teknik komunikasi terapeutik yang ada, dokter Obgyn telah melakukan 11 teknikkomunikasi terapeutik. (3) Komunikasi terapeutik, sangat penting diterapkan pada saat berinteraksidengan pasien, (4) Komunikasi terapeutik yang diterapkan Dokter Spesialis Obgyn bersifat konsultasidan monitor kondisi janin/bayi.
Strategi Komunikasi Pembangunan Kebudayaan Pasca Bencana 28 September 2018 (Studi pada Dinas Pendidikan dan Kebudayaan Kabupaten Donggala, Provinsi Sulawesi Tengah)
Authors: Sari Eka Vuspa
Published: February 2023

Tujuan dilakukannya penelitian ini guna mengetahui strategi komunikasi dan program pembangunan kebudayaan Dinas Pendidikan dan Kebudayaan Kab. Donggala pasca bencana 28 September 2018. Menggunakan metode penelitian kualitatif, mendeskripsikan hasil terkait strategi komunikasi pembangunan kebudayaan dan program kegiatan DIKBUD Kab. Donggala. Strategi komunikasi pembangunan kebudayaan DIKBUD Kab. Donggala tergambar pada perumusan perencanaan program yang memperhatikan aspek potensi budaya (kualitas dan kuantitas tenaga budaya), tingkat pendidikan dan seberapa besar tingkat pemikiran negatif terhadap kebudayaan. Pelaksanaan program dilakukakan dengan kerjasama baik dan intens antara pihak DIKBUD dan penggiat budaya, program sosialisasi pengembangan kebudayaan pedesaan dan pelestarian melalui berbagai event daerah, program pemeliharaan cagar budaya sudah pada tahap persiapan yang tergambar dengan ketersediaan data potensi yakni, tenaga, organisasi, benda dan non benda terkait kebudayaan.
BATAVIA KECIL DIBUMI RAFFLESIA (Potret kehidupan penambang emas di Desa Lebong Tandai)
Authors: Hidayat M. Arif
Published: February 2023

Penelitian ini bertujuan memberikan informasi kepada masyarakat tentang kehidupan masyarakat desa Lebong Tandai yang bermata pencaharian sebagai penambang emas. Hal ini dikarenakan kondisi desa Lebong Tandai tidak seperti dulu, pada zaman penjajahan Belanda desa ini memiliki sumber daya alam yang melimpah dan menjadikan desa ini kota metropolitan dengan hasil emasnya. Diawali dengan langkah hunting lokasi kemudian dilanjutkan dengan menyiapkan peralatan. Dengan tahap pra produksi, produksi dan pasca produksi. Hasil dari peneitian ini adalah desa ini dapat menjadi salah satu ikon wisata di Provinsi Bengkulu, yang memang layak untuk dinikmati karena memiliki wisata sejarah dan wisata alamnya. Lokasi ini adalah tempat penghasil emas pada masa peninggalan Belanda. Dahulu, wilayah tersebut pernah menjadi incaran banyak pihak seperti Portugis, Inggris, Belanda, China dan Jepang.
PERSEPSI OTAKU MENGENAI NILAI-NILAI KESETARAAN GENDER DALAM ANIME DAN MANGA NARUTO
Authors: Wijayadiningrat Sutrisno
Published: February 2023

Penelitian ini bertujuan untuk mengetahui bagaimana persepsi otaku mengenai nilai-nilai kesetaraan gender dalam anime dan manga Naruto dengan analisis teori perkembangan perseptual Gibson. Penelitian ini merupakan penelitian deskriptif kualitatif, yaitu penelitian untuk menjelaskan secara mendalam persepsi otaku mengenai nilai-nilai kesetaraan genderdalam anime dan manga Naruto. Teknik pengumpulan data yang digunakan yaitu menggunakan data utama yang diperoleh melalui wawancara mendalam dengan para informan. Hasil penelitian mengungkapkan persepsi otaku bahwa terwujudnya kesetaraan gender dalam anime dan manga Naruto telah ditandai dengan tidak adanya diskriminasi antara perempuan dan laki-laki, dan dengan demikian mereka memiliki akses, kesempatan berpartisipasi, kontrol atas pembangunan dan memperoleh manfaat yang setara dan adil dari pembangunan, sehingga dapat disimpulkan bahwa anime dan manga Naruto adalah serial yang memuat nilai-nilai kesetaraan gender.Kata kunci: anime, manga, persepsi otaku, kesetaraan gender, perseptual Gibson
ANALISIS DAYA TARIK IKLAN POP-UP YOUTUBE DI KALANGAN MAHASISWA
Authors: Pratama Devin Rizky , Gushevinalti .
Published: February 2023

Pendekatan penelitian ini adalah pendekatan kualitatif yang bersifat deksriptif. Proses pengumpulan data dilakukan dengan wawancara, observasi yang sudah dituliskan dalam catatan lapangan, dokumen pribadi, dokumen resmi, gambar foto dan sebagainya. Uji keabsahan data menggunakan teknik triangulasi data, dengan cara memeriksa data yang telah diperoleh melalui beberapa sumber. Teori yang dipakai dalam penelitian ini menggunakan teori AIDDA (Attention, Interest, Desire, Decision, Action) oleh Wilbur Schramm. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis daya tarik iklan pop-up dalam kalangan mahasiswa. Ketertarikan untuk menonton iklan pop-up muncul ketika iklan yang tayang memiliki unsur – unsur yang dapat menangkap perhatian dari mahasiswa. Hasil penelitian menunjukkan bahwa setelah iklan tersebut berhasil mendapatkan perhatian, maka secara otomatis mahasiswa memiliki ketertarikan terhadap apa yang diiklankan lalu melanjutkan tahapan selanjutnya seperti menunjukkan keinginan, membuat keputusan, lalu melakukan tindakan.
TRADITIONAL TITLES AND POLITICAL COMMUNICATION IN GORONTALO
Authors: Sumarjo  , Bajari Atwar
Published: February 2023

Each region has its own peculiarities that refers to the culture of its people. In this diverse culture, there are customs that are maintained as continuous, preserved and practiced in social life. The aims of the research are: (a) to reveal the meaning of adat title in local political communication, (b) to know the meaning of political communication capital in local government in Gorontalo, and (c) to get the pattern of political communication capital in local government in Gorontalo. The research doing by the critical ethnography, which is focus on the discovery, interpretation, and application of local knowledge to practice, rather than on testing hypotheses or outcomes. As a customary area, Gorontalo has a tradition of giving traditional titles (Pulanga)to the local son who is considered to have a great contribution to the region. The awarding of traditional titles/returns as a form of homage to new officials to distinguish them from others in society. The preservation of the traditions of the awarding ceremony is a sign that custom exists in Gorontalo society. So far, the awards have not clashed with democracy, although in certain aspects such as the recognition of women's leadership, not yet fully compatible with democracy. This paper examines how customary / traditional titles can be used as political capital in a contestation in Gorontalo for political office positions.Key words: gelaradat, modal politik, Gorontalo.
MAKNA UNGKAPAN “IKAN SEJEREK, BERE SECUPAK, MADAR…” DALAM AKTUALISASI KEHIDUPAN MASYARAKAT BERKAS KOTA BENGKULU
Authors: Loveana Nanda , Sinaga Lamhir S. , Budiman Dwi Aji
Published: February 2023

Tujuan penelitian ini adalah untuk mengetahui bagaimana masyarakat asli Bengkulu khususnya masyarakat Berkas mengaktualisasikan ungkapan “Ikan Sejerek, Bere Secupak, Madar…” dalam hidup sehari-hari, serta mengetahui bagaimana masyarakat memaknai ungkapan itu, dan bagaimana pergeseran nilai-nilai yang terjadi bila ditinjau dari kaum tua dan kaum mudanya. Metode yang penelitian gunakan dalam penelitian ini adalah penelitian kualitatif dengan metode deskriptif. Dari hasil penelitian yang peneliti lakukan dengan melakukan wawancara mendalam dan observasi bahwa ungkapan itu sekarang mengalami pola-pola pergeseran terhadap nilai-nilai yang ada di masyarakat dalam memaknai ungkapan itu. Kata Kunci ; Ikan Sejerek, Bere Secupak, Madar, Aktualisasi Kehidupan, Masyarakat Berkas, Kota Bengkulu
MANAGEMENT PUBLIC RELATIONS MELALUI PROSES KOORIENTASI BAGI KEPENTINGAN PENGELOLAAN ARSIP BISNIS JASA PERHOTELAN
Authors: Adhrianti Lisa
Published: February 2023

Penelitian ini bertujuan untuk mengidentifikasi proses manajemen Public Relations pada hotel Grand Marina Pantai Panjang Bengkulu melalui proses koorientasi komunikasi. Teori Koorientasi yang dipilih akan menunjukkan derajat orientasi manager PR dengan petugas administrasi keuangan dan front office hotel terkait dengan efektifitas pengelolaan arsip bagi kepentingan promosi hotel untuk membentuk dan meningkatkan citra positif perusahaan.Metode penelitian studi kasus intrisnsik dengan pendekatan kualitatif akan mendeskripsikan kesimpulan dan rekomendasi bagi pengembangan keilmuan sosial di bidang komunikasi, kearsipan dan kehumasan.Kata kunci : Management, Public Relations, Teori Koorientasi, Pengelolaan Arsip, Perhotelan
FABRICATION AND CONTROLLING MORPHOLOGY OF POLYETHYLENE OXIDE/SODIUM ALGINATE BEADS AND/OR FIBERS: EFFECT OF VISCOSITY AND CONDUCTIVITY IN ELECTROSPINNING
Authors: EREN BÖNCÜ Tuğba
Published: February 2023

Objective: The aim of the study is to determine the viscosity and conductivity of PEO/NaAlg polymer solutions, to formulate PEO/NaAlg beads, bead-on-string fibers and fibers via electrospinning, and to perform advanced morphological characterization studies on them.

Material and Method: Effect of PEO and NaAlg concentration and ratio of them on spinnability, viscosity and conductivity of solutions, and also on the morphological properties of PEO/NaAlg electrospun fibers, and beads (length, width and aspect ratio of beads, number of beads and bead area) were investigated.

Result and Discussion: As a result, electrospun materials were produced using PEO/NaAlg beads and/or fibers, which are valuable for medical and biological applications such as tissue engineering, wound dressing, drug delivery system. Viscosity and conductivity of solutions, and morphological properties of the obtained materials were found to be affected by PEO and NaAlg concentration and the ratio of them. Spinnability was improved thanks to the increase in conductivity in the presence of PEO. The lower viscosity and conductivity resulted in the production of beads that were generally smaller and greater in number in the material and having higher area. The morphological properties of PEO/NaAlg electrospun materials can be modified by controlling the parameters examined in the study.
Regeneration of coenzyme Q9 redox state and inhibition of oxidative stress by rooibos tea (Aspalathus linearis) administration in carbon tetrachloride liver damage
Authors: Kucharská J , Uličná O , Gvozdjáková A , Sumbalová Z , Vančová O , Božek P , Nakano M , Greksák M
Published: February 2023

The effect of rooibos tea (Aspalathus linearis) on liver antioxidant status and oxidative stress was investigated in rat model of carbon tetrachloride-induced liver damage. Synthetic antioxidant N-acetyl-L-cysteine (NAC) was used for comparison. Administration of carbon tetrachloride (CCl4) for 10 weeks decreased liver concentrations of reduced and oxidized forms of coenzyme Q9 (CoQ9H2 and CoQ9), reduced a-tocopherol content and simultaneously increased the formation of malondialdehyde (MDA) as indicator of lipid peroxidation. Rooibos tea and NAC administered to CCl4-damaged rats restored liver concentrations of CoQ9H2 and a-tocopherol and inhibited the formation of MDA, all to the values comparable with healthy animals. Rooibos tea did not counteract the decrease in CoQ9, whereas NAC was able to do it. Improved regeneration of coenzyme Q9 redox state and inhibition of oxidative stress in CCl4-damaged livers may explain the beneficial effect of antioxidant therapy. Therefore, the consumption of rooibos tea as a rich source of natural antioxidants could be recommended as a market available, safe and effective hepatoprotector in patients with liver diseases.
Bronze Age Platform Round-houses, Lee Burn Head, Cardrona, Scottish Borders
Authors: Barrett Dominic
Published: February 2023

An archaeological excavation was undertaken in 2020 to assess the condition and impact of accidental tree planting on two poorly recorded unenclosed platforms on the hills south of Cardrona, Scottish Borders. The work recorded two round-houses in the centre of the platforms, and excavation focused on Platform 2, revealing evidence of multi-phased occupation. An artefact assemblage of coarse stone tools, stone objects and pottery sherds was recovered. Radiocarbon dating and artefactual evidence suggest a Middle Bronze Age date.
Penguatan dan Pendampingan Pelaku Usaha Mikro Kecil dan Menengah (UMKM) di Desa Cikujang, Serangpanjang, Subang, Jawa Barat
Authors: Wulandari Serly
Published: February 2023

Maindset para pelaku Usaha Mikro Kecil dan Menengah (UMKM) yang beranggapan bahwa tanpa perlunya berbagai strategi dalam pemasaran, produk tetap akan laku dipasaran menjadi salah 1 faktor penyebab penjualan produk dengan kemasan yang sederhana dan apa adanya. Padahal, desain kemasan dari suatu produk yang dipasarkan merupakan hal pertama yang dilihat dan dapat mempengaruhi psikologis seorang konsumen, juga menjadi salah satu persyaratan khusus dalam pembuatan Izin Usaha melalui Online Single Submission (OSS) baik itu Nomor Induk Berusaha (NIB) maupun Sertifikat Pemenuhan Komitmen Produksi Pangan Olahan Industri Rumah Tangga (SPP-IRT). Kegiatan pengabdian ini bertujuan untuk memberikan penguatan berupa peningkatan literasi terkait desain kemasan produk dan izin usaha serta pendampingan dalam pembuatan desain kemasan baru dengan label lengkap dan Izin Usaha berupa NIB maupun SPP-IRT melalui OSS kepada pelaku UMKM Produktif di Desa Cikujang. Metode kegiatan pengabdian ini dilakukan melalui FGD bersama pelaku UMKM Produktif Desa Cikujang, edukasi melalui sosialisasi dan pelatihan terkait desain kemasan produk dan izin usaha serta simulasi dan pendampingan untuk membuat desain kemasan produk dengan label lengkap dan izin usaha. Temuan dalam kegiatan pengabdian ini, yakni adanya berbagai maindset negatif yang telah mengakar, terbatasnya kemampuan dan pengetahuan terkait perkembangan pasar, desain kemasan produk dan izin usaha maupun teknologi, terbatasnya sarana dan prasarana terkait teknologi dalam membuat desain kemasan produk dan mendaftarkan izin usaha melalui OSS bagi pelaku UMKM Produktif di Desa Cikujang. Kegiatan pengabdian masyarakat ini dapat disimpulkan memberikan dampak yang positif dengan output kegiatan berupa desain kemasan produk baru dengan label lengkap bagi pelaku UMKM produk Keripik dan Cemilan Kampung serta terbitnya izin usaha berupa 3 (tiga) NIB dan 2 (dua) SPP-IRT.
Angular Velocity-Addition Formula
Authors: Soltani Abolfazl
Published: February 2023

We are all familiar with Galileo's velocity-addition formula, which is about the sum of linear velocities. Our investigations show that there is also a formula for the sum of angular velocities. Here we obtain this formula.
Phosphoric acid pretreatment of poplar to optimize fermentable sugars production based on orthogonal experimental design
Authors: Chen Deming , Tang Wenjing , Wang Hui , Sheng Yequan , Tan Xin , Shi Yang , Fan Wei , Ge Shengbo
Published: February 2023

The recalcitrant structure of raw poplar limited the production of fermentable sugars when applied as the material in the pretreatment of biochemical conversions. Phosphoric acid pretreatment is an efficient method to destroy the compact lignocellulose matrix presence in the poplar. In this study, phosphoric acid pretreatment of poplar was optimised by an orthogonal experimental design [L9(33)] to improve enzymatic digestibility through investigating the effects of reaction temperature, time duration, and phosphoric acid concentration. The optimal conditions were selected based on the variance of chemical compositions, hemicellulose removal ratio, and delignification of the woody material after pretreatment. The optimum enzymatic hydrolysis yield of up to 73.44% was obtained when the phosphoric acid pretreatment performed at 190°C for 150 min under 1.5% of v/v phosphoric acid concentration.
Analysis of the amplified p-wave enables identification of patients with atrial fibrillation during sinus rhythm
Authors: Huang Taiyuan , Schurr Patrick , Muller-Edenborn Bjoern , Pilia Nicolas , Mayer Louisa , Eichenlaub Martin , Allgeier Juergen , Heidenreich Marie , Ahlgrim Christoph , Bohnen Marius , Lehrmann Heiko , Trenk Dietmar , Neumann Franz-Josef , Westermann Dirk , Arentz Thomas , Jadidi Amir
Published: February 2023

Aim

This study sought to develop and validate diagnostic models to identify individuals with atrial fibrillation (AF) using amplified sinus-p-wave analysis.

Methods

A total of 1,492 patients (491 healthy controls, 499 with paroxysmal AF and 502 with persistent AF) underwent digital 12-lead-ECG recording during sinus rhythm. The patient cohort was divided into training and validation set in a 3:2 ratio. P-wave indices (PWI) including duration of standard p-wave (standard PWD; scale at 10 mm/mV, sweep speed at 25 mm/s) and amplified sinus-p-wave (APWD, scale at 60–120 mm/mV, sweep speed at 100 mm/s) and advanced inter-atrial block (aIAB) along with other clinical parameters were used to develop diagnostic models using logistic regression. Each model was developed from the training set and further tested in both training and validation sets for its diagnostic performance in identifying individuals with AF.

Results

Compared to standard PWD (Reference model), which achieved an AUC of 0.637 and 0.632, for training and validation set, respectively, APWD (Basic model) importantly improved the accuracy to identify individuals with AF (AUC = 0.86 and 0.866). The PWI-based model combining APWD, aIAB and body surface area (BSA) further improved the diagnostic performance for AF (AUC = 0.892 and 0.885). The integrated model, which further combined left atrial diameter (LAD) with parameters of the PWI-based model, achieved optimal diagnostic performance (AUC = 0.916 and 0.902).

Conclusion

Analysis of amplified p-wave during sinus rhythm allows identification of individuals with atrial fibrillation.
Efficacy of unblinded and blinded intermittently scanned continuous glucose monitoring for glycemic control in adults with type 1 diabetes
Authors: Guo Lixin , Li Yuxiu , Zhang Mei , Xiao Xinhua , Kuang Hongyu , Yang Tao , Jia Xiaofan , Zhang Xianbo
Published: February 2023

Objective

Intermittently scanned continuous glucose monitoring (isCGM) is used for unblinded or blinded monitoring of interstitial glucose. We aimed to compare the efficacy of blinded and unblinded isCGM with the FreeStyle Libre system for glycemic control in adults with type 1 diabetes (T1D).

Research design and methods

This randomized clinical trial conducted between October 2018 and September 2019 across four endocrinology practices in China included 273 adults aged ≥18 years with T1D, who were randomly divided in a 2:1 ratio into the unblinded (n = 199) or blinded isCGM group (n = 78). In the blinded group, the clinician used FreeStyle Libre Pro system for monitoring, but self-monitoring was also performed by the patients.

Results

Two hundred sixteen (78%) participants completed the study (152 [75%] in the unblinded and 64 [82%] in the blinded group). At 12 weeks, a significant increase in TIR (3.9-10.0 mmol/L) was only observed in the unblinded group, along with a significant decrease in hyperglycemia (>13.9 mmol/L), hypoglycemia (<3.0 mmol/L), glycemic variability. Further, the mean HbA1c reduction from baseline to 12 weeks was 0.5% in the unblinded isCGM group and 0.4% in the blinded isCGM group respectively (P < 0.001), but the significance did not remain after adjustment for between-group differences. Finally, 99.5% of the blinded isCGM values and 93.8% the of unblinded isCGM values were obtained at the final visit.

Conclusions

The unblinded isCGM system was associated with benefits for glucose management, but nearly 100% of the attempted profiles were obtained successfully with the blinded isCGM system. Thus, combining real-time and retrospective data with isCGM might be the most impactful way to utilize flash glycemic monitoring devices.
Game study on safety supervision of imported aquatic products in China
Authors: Tong Xia , Gu Yutong , Yang Ruirui , Gao Shenrong
Published: February 2023

With the expanding scale of aquatic product imports, safety issues have arisen. Among them, the lack of supervision by government agencies, illegal importation by unscrupulous enterprises and the lack of regulatory bodies such as consumers are major reasons for the occurrence of unsafe imported aquatic products. Therefore, this paper adopts a two-by-two static game model between government agencies and importers, importers and consumers, and a three-way sequential dynamic game model between government agencies, importers and consumers to analyze the causes of quality and safety problems of imported aquatic products in China. The results show that when the safety problems of imported fishery products occur, consumers choose to report importers when the compensation they receive due to reporting increases or when the cost of reporting is reduced by not reporting; government agencies choose to strictly regulate importers when the cost of regulation is reduced by loose regulation and reputation loss increases, or when the revenue from fines obtained by strict regulation increases. It is further verified through empirical evidence that both government agency regulation and consumer monitoring have positive effects on importers’ self-regulation. Finally, countermeasures to ensure the quality and safety of imported aquatic products in China are proposed.
Mucosal immunization with Ad5-based vaccines protects Syrian hamsters from challenge with omicron and delta variants of SARS-CoV-2
Authors: Braun Molly R. , Martinez Clarissa I. , Dora Emery G. , Showalter Laura J. , Mercedes Annette R. , Tucker Sean N.
Published: February 2023

SARS-CoV-2 variant clades continue to circumvent antibody responses elicited by vaccination or infection. Current parenteral vaccination strategies reduce illness and hospitalization, yet do not significantly protect against infection by the more recent variants. It is thought that mucosal vaccination strategies may better protect against infection by inducing immunity at the sites of infection, blocking viral transmission more effectively, and significantly inhibiting the evolution of new variants of concern (VOCs). In this study, we evaluated the immunogenicity and efficacy of a mucosally-delivered, non-replicating, adenovirus type 5-vectored vaccine that expresses the spike (S) gene of Wuhan (rAd5-S-Wuhan), delta (rAd5-S-delta), or omicron (rAd5-S-omicron) SARS-CoV-2 VOCs. Hamsters were immunized with these vaccines intranasally prior to challenge with omicron or delta variants. Additionally, one group was vaccinated by oral gavage with rAd5-S-Wuhan prior to challenge with the delta variant. Both intranasal and oral administration of rAd5-S-Wuhan generated cross-reactive serum IgG and mucosal IgA to all variant spike and RBD proteins tested. rAd5-S-omicron and rAd5-S-delta additionally elicited cross-reactive antibodies, though rAd5-S-omicron had significantly lower binding antibody levels except against its matched antigens. Two weeks after the final vaccination, hamsters were challenged with a SARS-CoV-2 variant; omicron or delta. Whether matched to the challenge or with rAd5-S-Wuhan, all vaccines protected hamsters from weight loss and lung pathology caused by challenge and significantly reduced viral shedding compared to placebo. Vaccination with rAd5-S-Wuhan provided significant protection, although there was an improved reduction in shedding and disease pathology in groups protected by the matched VOC vaccines. Nevertheless, Wuhan-based vaccination elicited the most cross-reactive antibody responses generally. Overall, heterologous vaccination via mucosal routes may be advantageous for second-generation vaccines.
Allogeneic hematopoietic stem cell transplantation in the COVID-19 era
Authors: Bordat Jonathan , Maury Sébastien , Leclerc Mathieu
Published: February 2023

Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) recipients are especially vulnerable to coronavirus disease 19 (COVID-19), because of their profound immunodeficiency. Indeed, the first pandemic wave was marked by a high mortality rate in this population. Factors increasing immunodepression such as older age, immunosuppressive treatments or a short delay between transplant and infection appear to worsen the prognosis. Many changes in clinical practice had to be implemented in order to limit this risk, including postponing of transplant for non-malignant diseases, preference for local rather than international donations and for peripheral blood as stem cell source, and the widespread use of cryopreservation. The great revolution in the COVID-19 pandemic came from the development of mRNA vaccines that have shown to be able to prevent severe forms of the disease. More than 75% of allo-HSCT recipients develop seroconversion after 2 doses of vaccine. Multiple studies have identified lymphopenia, exposure to immunosuppressive or anti-CD20 therapies, and a short post-transplant period as factors associated with a poor response to vaccination. The use of repeated injections of the vaccine, including a third dose, not only improves the seroconversion rate but also intensifies the immune response, both in B cells and T cells. Vaccines are an effective and well-tolerated method in this high-risk population. Some studies investigated the possibility of immune protection being transferred from a vaccinated donor to a recipient, with encouraging initial results. However, dynamic mutations and immune escape of the virus can lead to breakthrough infections with new variants in vaccinated individuals and still represent a threat of severe disease in allo-HSCT recipients. New challenges include the need to adapt vaccine protection to emerging variants.
Intervention strategies in early childhood to prevent celiac disease—a mini-review
Authors: Andrén Aronsson Carin , Agardh Daniel
Published: February 2023

A higher intake of gluten during childhood is associated with increased risk of celiac disease, and the incidence of celiac disease peaks shortly after the time point when associations with higher gluten intake during the second and third year of life occur. Additional environmental factors are most likely necessary for celiac disease to develop. It is hypothesized that gastrointestinal infections increase gut permeability and exposure to gluten. Alternatively, infections may lead to gut dysbiosis and chronic inflammation, with leakage of self-antigens that mimic gluten peptides that leads to an autoimmune-like response. Different gluten interventions to prevent celiac disease have been proposed. Early clinical studies suggested an optimal time point introducing gluten between 4 and 6 months of age while the infant is being breastfed. However, later clinical trials on reduced gluten intake given to infants have shown no protection from celiac disease if gluten introduction was delayed or if gluten was introduced in small amounts during the child’s first year of life. Still, more randomized clinical trials (RCTs) are warranted to answer the question if a reduced amount of gluten, not only at the time of introduction during infancy but also in a longer time frame, will prevent children at genetic risk from having lifelong celiac disease. It needs to be clarified whether dietary interventions are effective strategies to be proposed as future prevention of celiac disease in the general population. The present mini-review provides an overview of ongoing or completed RCTs that have focused on interventions during early childhood with the aim of preventing celiac disease.
Pathological complete response to neoadjuvant tislelizumab plus chemotherapy in stage IIIB small cell lung cancer: A case report and literature review
Authors: Zhou Nan , Chen Yuhong , Huang Qian , Jiang Lili , Liao Hu , Gou Hongfeng , Lu You , Che Guowei , Zhang Yan
Published: February 2023

Immunotherapy plus chemotherapy has been approved for the first-line treatment of extensive-stage small cell lung cancer (ES-SCLC, stage IV). Recently, the 2023 version of the National Comprehensive Cancer Network Guidelines recommended immunotherapy plus chemotherapy as the neoadjuvant regimen in patients with resectable non-small cell lung cancer (NSCLC). However, it is still unclear whether the combination regimen of immunotherapy plus chemotherapy is also beneficial for SCLC in the neoadjuvant context. Here, we report the case of a patient with stage IIIB SCLC who showed long-term survival and good tolerance to the neoadjuvant chemoimmunotherapy consisting of tislelizumab (an anti–PD-1 monoclonal antibody) plus etoposide-carboplatin. The patient achieved pathological complete response after receiving two cycles of neoadjuvant tislelizumab and chemotherapy followed by surgery. Two courses of post-operative tislelizumab and etoposide-carboplatin treatment were performed. The patient has survived for more than 23 months with no recurrence or metastases after neoadjuvant therapy. Multiplexed immunofluorescence and immunohistochemistry staining showed that the post-treatment specimens had remarkable immune cells infiltration, including CD3+ T cells, CD4+ T cells, and CD8+ T cells, which contrasted with very low levels of these cells in the pre-treatment samples. This study is, to the best of our knowledge, the first attempt to present the neoadjuvant chemoimmunotherapy of tislelizumab in combination with etoposide-carboplatin in SCLC. Our study suggested that neoadjuvant tislelizumab plus chemotherapy may facilitate radical resection and benefit patients with locally advanced (stage IIB-IIIC) SCLC.