bluuebunny/crossref_metadata_2025 huggingface dataset:
The Inter-American System for the Protection of Human Rights and Persons with Disabilities: challenges and perspectives beyond the non-discrimination rule
Authors: Caballero Pérez Adriana , Guzmán Rincón Andrés Mauricio
Published: April 2022

The present article focuses on the InterAmerican System for the Protection of Human Rights (Inter-American System) in the context of disability. It addresses several relevant issues regarding complaint mechanisms. The article is divided into three main parts. The first part explains the organs of the Inter-American System and corpus iuris centered on disability rights. The second part explores rights to nondiscrimination and non-segregation of persons with disabilities based on relevant reports and recommendations issued by the Inter-American Commission on Human Rights, as well as case-law of the Inter-American Court of Human Rights. The last part of this article includes some concluding remarks.
Liability for Withholding Assistance: General Clause or Closed List? A Review of Competing Models in Arab Legislations
Authors: Al Waleed Saher , Jadalhaq Iyad Mohammad
Published: April 2022

This study reviews two main approaches for dealing with omission of assistance in the criminal laws of Arab jurisdictions. The first approach adopts a general clause on the crime of withholding assistance. This approach, following the model of the French Code pénal, prioritises the right to life and bodily integrity over individual freedom, and has been adopted in Algeria, the UAE, Qatar, Lebanon, Bahrain, Morocco, and Sudan. The second approach restricts criminal omission of assistance to a closed list of cases, in which it mandates a duty to intervene. The Palestinian Criminal Code follows this alternative model, with origins in English criminal law, prioritising individual freedom. The study presents the viability of a general omission clause in criminal law. It contrasts this with the absence of a comparable clause in civil liability, where Arab jurisprudence has instead codified a set of requirements for simple omission to result in civil liability.
Digital transformation of music aggregation and distribution companies: The case of Russia
Authors: Altynov Artem
Published: April 2022

Currently distributors ensure the operation of the whole value chain in the music industry, while most researchers focus on technological, streaming and copyright impact in light of digitalization. This paper tries to understand the influence of digitalization on business models and the role of music distributors in a value chain. Research identifies operational processes that were changed due to digitalization, barriers that arose, and actions taken to overcome them on the corporate level. Through retrospective case study based on an interview with the CEO, the experience of the Russian music distribution company Broma16 is analyzed. This paper describes the goals of business model transformation, drivers, performed activities and their results. The research derives four consequences of digitalization for the firm’s business model and role in a value chain: the firm can be considered as a technological company rather than a music company. Distribution relies on digital instruments for management and marketing. Local intermediaries get more opportunities to enter foreign markets, but they have to perform innovations in these markets. Music distributors operate at the complicated intersection of copyright and technological aspects. The research applies a general theoretical framework for the study of digital transformation of business models. A similar approach can be used to do research on companies in music and other creative industries, and to conduct workshops with industry representatives. The paper provides value for practitioners in emerging music markets, for example, Brazil, Argentina and Mexico, due to the presentation of management practices towards digitalization and the consequences of transformation for the distribution role.
Sociable Space and Social Policies in Iranian Urban Local Communities
Authors: Валибейги Моджтаба , Серешти Марьям
Published: April 2022

Changes in the spatial arrangement and dominant social processes of urbanization over the past few decades in Iran have failed to allow communities to shape their social interactions. This paper is a synthesis of a quantitative and qualitative study of community responses aimed at creating good social spaces within local communities in Tehran. First, we identified Perceived Residential Environment Quality indicators (PREQ) as tools for determining the effects of environmental quality (EQ) of sociable spaces. Then key social governance-­related concerns were studied on the basis of five questions including: Are the decision-­making and regulatory processes open, rigorous and accountable? Is the environmental quality assessment process adequate? Does the government have the intention and capacity to monitor and enforce regulations? Has the interaction of community members in decisions been timely and have local actors been significantly involved? Have local governments been included in decision making? It is observed that community residents identified systematic gaps and problems in decision-­making processes and sometimes even used them to advance individual interests, because they do not feel that they are dealt with justice and see the current laws as depriving them of access to more resources. In many cases, regulatory protections and assessments of social and environmental values lagged behind the physical construction. Administrative bureaucracies without creating a real participation have been increased. Overall, we argue that as a common ground, environmental activities can bring together people in the local community but when such functioning systems are put in place to ensure community engagement. So, despite extensive formal endorsement, they should provide for an effective as opposed to a symbolic involvement of stakeholders other than governmental authorities.
Insights into ESP Vocabulary Learning Strategies Used by Vietnamese Tertiary Students
Authors: Duong Tham My
Published: April 2022

Research background: ESP vocabulary is pivotal for learners to master the ESP subject matter, so there has been growing interest in how vocabulary learning strategies (VLS) for ESP are used. In addition, understanding the underlying reasons for using VLS for ESP is indispensable.Purpose of the study: To this end, this paper aims at exploring VLS for ESP in terms of metacognitive strategies, cognitive strategies, memory strategies, determination strategies, social (discovery) strategies, and social (consolidation) strategies employed by Vietnamese tertiary students and their reasons for such VLS deployment.Methods: It involved 270 technical students from a higher education institution in Ho Chi Minh City, Vietnam, who were conveniently selected. This mixed-methods research gathered data by means of a closed-ended questionnaire and semi-structured interviews.Findings and Value added: The findings unraveled that participants employed strategies for learning ESP lexical items moderately. Remarkably, the metacognitive strategies were the most frequently used among six groups of VLS for ESP, whereas social (consolidation) ones received the least attention. The results further uncovered that participants used VLS for ESP because of efficiency and regular practice, while lack of confidence and environment for practice hindered them from making use of VLS for ESP. Such findings are expected to enrich the knowledge of how students learn ESP lexical items in the Vietnamese context and other similar ones.
Family’s role and their Challenging Commitment to English Language Learning: A systematic Review
Authors: Philominraj Andrew , Ranjan Ranjeeva , Saavedra Rodrigo Arellano , Cerón Urzúa Claudio Andrés
Published: April 2022

Background: The English language occupies a prominent role in today’s globalized world. The importance of this language is on the increase to the extent that this has become a major concern for governments, curriculum designers, educators, and parents. There are several factors, which contribute to achieving the successful learning of the English language. One of these factors is the role of the family and their involvement in the language development of their children. Purpose and Method: The present systematic review is framed in a descriptive qualitative approach since its main objective is to analyze articles that contain information regarding family’s role and their challenging pedagogical commitment with their children to the learning of the English language. For this purpose, 16 empirical studies retrieved from SCOPUS and the Web of Science database published between 2016 and 2021 in different EFL contexts were analyzed. The present work followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines and was analyzed thematically. Four themes were identified from the empirical studies and were discussed further. Results: The results clearly suggest that the higher commitment of parents is directly proportional to the success rate in the learning of the English language. It also revealed the need for integrating the Family in the English language learning process and be considered while formulating any language/educational policy as well as curriculum development involving English as a foreign language (EFL) learning context in the future. Finally, the study provides information on limitations and implications followed by a conclusion.
Secukinumab Associated Choroidal Neovascularization
Authors: Edward B Miller , Oren S Yovel
Published: April 2022

A previously healthy 38-year-old woman with non-radiographic spondyloarthritis (nrSpA) developed juxta-foveal Choroidal Neovascularization (CNV) in the right eye three months after starting treatment with the anti-IL-17A inhibitor secukinumab. As there was no sign of ocular inflammation, no known association with CNV and this rheumatic disease, and other etiologic etiologies were excluded, this biologic agent was the suspected cause. Drug discontinuation and treatment with bevacizumab resulted in full suppression of the neovascular activity. IL-17 has a purported etiologic role in ocular neovascular diseases. The onset of this process in a patient receiving anti-IL-17 therapy suggests a possible causative role requiring further clarification.
[RETRACTED] Sports Illustrated Intensi-T - Help You Build Muscle, How can I Get Muscle Fast? v1
Authors: Illustrated Intensi-T Sports
Published: April 2022

[RETRACTED]

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[RETRACTED] Kalmaste CBD Oil Reduces Anxiety, Stress, Improves Sleep*Buy Now* v1
Authors: not provided KainScnt
Published: April 2022

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Mal-Herbal Protocol Version 8 dated 20th August 2020 v1
Authors: not provided kamakak
Published: April 2022

Background: Malaria is a disease of poverty and is still a major global health problem, especially in Africa. Almost all African countries are located in a malaria-endemic area (Figure 1). It was estimated that 228 million cases of malaria occurred worldwide in 2018.The development of insecticide and artemisinin resistance threatens the gains that have been made in the control and elimination of malaria. Tanzania is among the top ten highest-burden countries in the world. Therefore, the scientific investigation of antimalarial herbal remedies to prove their efficacy and safety may be of benefit to the worldwide agenda of malaria control and elimination.Objective: The first primary objective of this study will be to assess the safety and tolerability of malaria herbal remedy of Maytenus senegalensis among healthy male adults aged 18 to 45 years in Tanzania. The second objective is to evaluate the safety, tolerability as well as efficacy of malaria herbal remedy Maytenus senegalensis (MALHERBAL) for the treatment of Tanzanian adults aged 18 to 45 years with uncomplicated malaria compared to Artemether-lumefantrine.Materials & Methods: The study design of the trial will be single-center phase IIa and open-label clinical research with a population of 116 male participants aged 18 to 45 years residing in Bagamoyo District or nearby districts. The primary endpoint is the number of adverse events (AE) after drug intake until day 28. Secondary endpoints are the number of serious adverse events (SAE), adequate clinical and parasitological response rate (ACPR) on day 28, clinical and parasitological failure rates on days 3, 7, 14, and 28, changes in hemoglobin/hematocrit until day 28, and fever and parasite clearance time. Oocyst burden on days 7 and 14 as well as theNumber of developed early ring stage P. falciparum parasites. Case report form will be used to collect all study endpoint data. Categorical data will be presented by treatment group and time-point using counts and percentages of participants. Continuous variables will be also presented by treatment group and time-point, using (at least) the mean, standard deviation (SD), median, minimum (Min), maximum (Max), and number of observations (N). The analysis will be descriptive. In addition, 95% Confidence Intervals will be computed by the treatment group for all the efficacy end-points.
[RETRACTED] Oprah Winfrey CBD gummies@>>> https://www.facebook.com/OprahWinfreyCBDGummiesReviews/ v1
Authors: Winfrey CBD gummies Oprah
Published: April 2022

[RETRACTED]

Oprah Winfrey CBD gummies Rank@:- http://purecbdoilsbrand.com/oprah-winfrey-cbd-gummies/
Fractional Integration Based Feature Extractor for EMG Signals
Authors: SAÇU İbrahim Ethem
Published: April 2022

Electromyography (EMG) signals have been extensively used for
identification of finger movements, hand gestures
and physical activities. In the classification of EMG signals, the
performance of the classifier is widely determined by the feature
extraction methods. Thus, plenty of feature extraction methods
based on time, histogram and frequency domain have been
reported in literature. However, these methods have several
drawbacks such as high time complexity, high computation demand
and user supplied parameters. To overcome these deficiencies, in
this work, a new feature extraction method has been proposed
to classify EMG signals taken from two different data sets finger
movements (FM) and physical actions (PA). While FM data set
includes 14 different finger movements, PA data set involves
20 different physical activities. The proposed method is based
on numerical fractional integration of time series EMG signals
with different fractional-orders. K Nearest Neighborhood (KNN)
classifier with 8-fold cross validation has been employed for
prediction of EMG signals. The derived fractional features can
give better results than the two commonly used time domain
features, notably, mean absolute value (MAV) and waveform
length (WL) in terms of accuracy. The experimental results are
also supported by statistical analysis results.
Modification of quality assessment tool for artificial intelligence diagnostic test accuracy studies (QUADAS-CAD)
Authors: Kodenko M. R. , Reshetnikov R. V. , Makarova T. A.
Published: April 2022

.
The application of MR morphometry of the brain in patients with spastic forms of cerebral palsy in order to determine the predictors of the diagnosis of cerebral palsy and the presence of a unilateral form
Authors: Kliuev E. A. , Sheiko G. E. , Sharabrin E. G.
Published: April 2022

.
Low-dose computed tomography for the diagnosis of COVID-19
Authors: Rumyantsev D. A. , Blokhin I. A. , Gonchar A. P. , Gombolevsky V. A. , Reshetnkov R. V.
Published: April 2022

ABSTRACT
Artificial intelligence approaches in histology
Authors: Yasnov A. O. , Remez A. I. , Mayer A. O.
Published: April 2022

ABSTRACT
Long-term botulinum therapy for overactive bladder: myths and reality
Authors: Kuzmin Igor V. , Slesarevskaya Margarita N. , Amdiy Refat E. , Ulitko Tatiana V. , Al-Shukri Salman Kh.
Published: April 2022

The review article presents data on the efficacy and tolerability of intravesical injections of botulinum toxin in patients with overactive bladder. The pharmacological bases of the use of botulinum therapy in this category of patients are described in detail. Data on the history of the use of botulinum toxin for medical purposes are presented. Experience to date shows that intravesical botulinum toxin injections are highly effective and well tolerated in patients with refractory overactive bladder. Botulinum therapy is included in domestic and foreign clinical guidelines as a 3rd line treatment for idiopathic and neurogenic overactive bladder. Indications for its implementation are the inefficiency and/or poor tolerability of oral pharmacotherapy. It is noted that the only botulinum toxin recommended for use in clinical practice for the treatment of overactive bladder is onabotulinumtoxin A (Botox). The results of clinical studies are presented, showing that the effectiveness and safety of botulinum therapy do not decrease over time.
Benign prostatic hyperplasia with high PSA values: a clinical case
Authors: Protoshchak Vladimir V. , Paronnikov Mihail V. , Karpushchenko Evgenij G. , Ignateva Valentina V. , Ovchinnikov Dmitrii V. , Erohina Alina A.
Published: April 2022

The article presents a clinical case of treatment of a patient with benign prostatic hyperplasia and high serum prostate-specific antigen values. Prostate-specific antigen (total) blood level 160.1 ng/ml. The volume of the prostate gland is 230 cm3, the average proportion is 53 mm. The patient underwent a full range of diagnostic tests. A retropubic transvesical adenomectomy was performed. During a histological examination of the preparation, no data was obtained for the presence of an oncological process.
Cryoablation of localized renal cancer on the MKS cryotherapy unit with liquid nitrogen as a cryogen: functional and oncological efficiency of the method
Authors: Shchekuteev Nikita A. , Nosov Alexander K. , Prohorov Georgiy G. , Burovik Ilia A.
Published: April 2022

BACKGROUND: Ablation is a method of destroying a pathological focus using a controlled temperature or other effect. The most promising ablative treatment for localized kidney cancer today is cryoablation.
AIM: To analyze functional and oncological results of cryoablation of localized kidney cancer using liquid nitrogen as cryogen.
MATERIALS AND METHODS: Between 2017 and 2020, 56 patients with suspected localized kidney cancer were observed and treated at the N.N. Petrov National Medical Research Center of Oncology. With morphological verification, renal cell carcinoma was detected in 19 (65.5%) patients, chromophobe renal cell carcinoma in 3 (10.4%), oncocytoma in 3 (10.4%), in 4 (13.8%) cases the tumor was not detected in morphological material. All patients underwent cryoablation using the MKS cryotherapy unit with liquid nitrogen as a cryogen (ultrasound-guide cryotherapy was performed in 4 (7.1%) cases, CT-guide in 46 (82.1%), laparoscopically in 6 (10.7%) patients).
RESULTS: Renal function in this study was assessed by creatinine level and glomerular filtration rate (GFR) before and after cryoablation. The creatinine level before cryoablation was 101 18 mol/l, after 113.8 18 mol/l (p = 0.21), GFR before cryoablation 63 13 ml/min, after 65 13 ml/min. These differences were not significant (p = 0.87). Local disease control was achieved in 100% of cases. The overall and specific survival rate were 100% (one patient died from synchronous primary multiple cancer at 4 years of observation), the survival rate to recurrence was 90.9 3.9%, and the event-free survival was 70.2 6.6%. During the follow-up period, 9 (16%) recurrences of the disease were diagnosed.
CONCLUSIONS: Cryoablation makes it possible to maintain a large volume of renal parenchyma, thereby not reducing the functional ability of the kidney. In addition, the outcomes and survival rates are quite high, making it an alternative option for other nephron-saving operations.
Malacoplakia of the urinary bladder. Clinical case report
Authors: Barysheva Olga Yu. , Simanov Ruslan N. , Bukalev Andrej V.
Published: April 2022

A clinical case of bladder malacoplakia in a 33-year-old woman, clinically manifested by dysuria and gross hematuria, is presented. Malacoplakia is a rare tumor-like granulomatous-inflammatory disease with a predominant lesion of the bladder mucosa. The literature describes extravesical forms of malacoplakia with involvement of the ureters, renal pelvis and calyces, prostate, testicles and their appendages, intestines and other organs. In women, the disease occurs 4 times more often than in men. The reasons for the development of malacoplakia are not fully understood. The main importance in its pathogenesis is attached to the infectious factor and immunosuppression. Diagnosis is based on histological examination of bladder biopsy specimens and the detection of Hansemann cells and Michaelis Gutman bodies. Treatment of patients with malacoplakia consists of resection of the affected areas of the bladder and antibiotic therapy.
Okul Psikolojik Danışmanlarında Mesleki Doyum ve Psikolojik İyi Oluş: İş Yaşamı Psikolojik Esnekliğinin Aracı Rolü
Authors: GÜNEL Dilek , AYDIN Yasin
Published: April 2022

Bu çalışmanın amacı, okul psikolojik danışmanlarının mesleki doyumları ile psikolojik iyi oluşları arasındaki ilişkide iş yaşamı psikolojik esnekliğinin aracılık rolünü yapısal eşitlik modellemesi (YEM) ile incelemektir. İlişkisel araştırma yönteminin kullanıldığı bu çalışmanın örneklemini 291’i kadın, 114’ü erkek olmak üzere toplam 405 (M = 29,79, SS = 6,99) okul psikolojik danışmanı oluşturmaktadır. Araştırmada veri toplama aracı olarak Kişisel Bilgi Formu, Mesleki Doyum Ölçeği, Psikolojik İyi Oluş Ölçeği, İş Yaşamı Kabul ve Eylem Formu kullanılmıştır. Araştırmada kurulan modelin analiz sonuçlarına göre mesleki doyumun, psikolojik iyi oluş ve iş yaşamı psikolojik esnekliğini anlamlı bir şekilde yordadığı belirlenmiştir. Ayrıca yapısal eşitlik modellemesi doğrultusunda gerçekleştirilen analiz sonucunda iş yaşamı psikolojik esnekliğinin, mesleki doyum ve psikolojik iyi oluş arasındaki ilişkide kısmi bir aracı etkiye sahip olduğu anlaşılmıştır. Okul psikolojik danışmanlarının psikolojik iyi oluş düzeylerindeki varyansın %11’inin iş yaşamı psikolojik esnekliği tarafından açıklandığı sonucuna ulaşılmıştır. Araştırmada elde edilen bulgular, güncel alan yazın ışığında tartışılmıştır. Araştırmanın bulguları doğrultusunda ilgili öneriler sunulmuştur.
NILAI ESTETIS RIAS DAN BUSANA TARI TANI MELATI DESA KALIPRAU SANGGAR SENI KALOKA KABUPATEN PEMALANG
Authors: Mahesa Gessila Siva , Indriyanto R
Published: April 2022

Abstract: Make-up are visual aspects in the elements of dance, which means make-up or grooming and dressing aimed at inviting the audience's attention to enjoy and interpret the content of dance offerings. The aesthetic value of the make-up and clothing of Tani Melati Dance includes the appearance value, the content or meaning value, the expression value of each form, process, color that combines the combination of results of jasmine flower ronce as village branding  in realizing the purity of jasmine sambac and the activities of jasmine farmers. Key Words: Aesthetic Value, Make-up, Tani Melati Dance  Abstrak: Rias dan busana adalah aspek visual dalam unsur elemen tari yang berarti berias atau dandan dan berbusana yang bertujuan untuk mengundang perhatian penonton untuk menikmati dan menginterpretasikan isi sajian tari. Nilai esteis rias dan busana Tari Tani Melati meliputi nilai kesan penampilan, nilai isi atau makna, nilai pengungkapan dari setiap perpaduan bentuk, proses, warna yang menggabungkan perpaduan dari hasil ronce bunga melati sebagai branding desa dalam mewujudkan kemurnian Jasmine Sambac dan aktivitas petani melati. Kata kunci: Nilai Estetis, Rias dan Busana, Tari Tani Melati
Diklofenak Sodyumun Zebra Balığı (Danio rerio) Larvaları Üzerindeki Teratojenik ve Gelişimsel Toksisitesinin Değerlendirilmesi
Authors: ÖZHAN TURHAN Duygu
Published: April 2022

Bu çalışmada tıpta ve veteriner hekimlikte ağrı ve iltihabı kontrol etmek için kullanılan diklofenak sodyumun (DKFS) zebra balığı embriyoları ve larvaları üzerindeki etkileri değerlendirilmiştir. Embriyolar 96 saat süreyle 0.21-5.33 mg L-1 DKFS'ye maruz bırakılmış ve bu bireylerin hayatta kalma oranları, kalp atım sayıları, kuluçkadan çıkma oranları ve vücut malformasyonları belirlenmiştir. LC50, EC50 ve teratojenik indeks (TI) değerleri sırasıyla 1.55 ve 0.81, 1.91 olarak hesaplanmıştır. DKFS, hesaplanan TI değerine göre zebra balığı embriyoları için teratojendir. 0.47 mg L-1 ve daha yüksek konsantrasyonlarda DKFS zebra balıklarında, perikardiyal ödem, yolk kesesi ödemi, kuyruk malformasyonu ve omurga eğriliğine neden olmuştur. En sık rastlanan malformasyonlar perikardiyal ve yolk kesesi ödemi olarak belirlenmiştir. 0.7 mg L-1 ve daha yüksek konsantrasyonlarda zebra balıkları larvalarının boy uzunluklarında ve dakikadaki kalp atım sayılarında önemli oranda inhibisyona neden olmuştur. 2.37 mg L-1 ve daha yüksek konsantrasyonlarda DKFS’nin ise zebra balıklarının kuluçkadan çıkma oranlarını %50’nin altına düşürdüğünü göstermiştir. Bu sonuçlar, DKFS'nin zebra balığı gelişimi üzerinde olumsuz etkilere neden olduğunu ve sucul ortama girmesi durumunda su ekosistemini olumsuz etkileyebileceğini göstermektedir.
DEVLETE GÜVEN VE MALİ YERELLEŞMENİN GÜVEN ÜZERİNDEKİ ETKİSİ
Authors: ÇOBAN Hilmi , BALIKÇIOĞLU Eda
Published: April 2022

Sosyal sermayenin temel belirleyicilerinden birisi toplumdaki bireylerin hem birbirine karşıi hem de devlete arşı duydukları güvenin derecesidir. Birey ve devlet arasındaki bağın güçlenmesi ve yabancılaşma sürecini yavaşlatması bakımından mali yerelleşmenin de güven üzerinde belirgin bir etkiye sahip olduğu kabul edilmektedir. Buna bağlı olarak çalışmada 18 OECD ülkesi için 2011-2022 yılları arasındaki güven endeks değerleri ve mali yerelleşmeye ilişkin yıllık verileri kullanarak ikili logit modeli analizi uygulanmıştır. Çalışma sonucunda harcama yönünde mali yerelleşmenin artmasının devlete olan güveni arttırdığı tespit edilmiştir.
YENİLENEBİLİR ENERJİ KAYNAKLARININ YAYILIMINDA SOSYOEKONOMİK FAKTÖRLERİN ETKİSİ
Authors: YILDIZ Özge , ULUCAK Recep
Published: April 2022

Globalleşmenin yoğun olarak yaşandığı günümüzde ülkelerin birbirleri ile olan etkileşimleri artmasıyla ticari faaliyetler de artmış ve üretim-tüketim kapasitelerinde de büyük oranda artış yaşanmıştır. Bu süreçte enerji hem ekonomik hem de sosyal refaha erişmenin itici gücü olmuştur. Türkiye gün geçtikçe ekonomik faaliyetlerini artıran bir ülkedir. Temel üretim girdisi olarak hem ekonomik hem de sosyal açıdan kalkınmayı sürdürmek ve ihtiyaçlara anında cevap verebilmek adına enerji önemli bir faktördür. Türkiye’nin artan enerji ihtiyacının büyük bir bölümü ithalat ile karşılanmaktadır. Dolayısıyla ülke içinde veya dışında herhangi bir sorun yaşandığında enerjiye erişim aksayabilir veya tamamen durabilir. Bu yüzden Türkiye’nin yenilenebilir enerji sistemlerini ülke içine entegre etmesi, kendi kendine yetebilmesi önem arz etmektedir. Bu düşünceden hareketle bu çalışama da literatürde nispeten yeni olarak kullanılan Belirsizlik, Beşerî Sermaye, Gelir Düzeyi ve Küreselleşme değişkenlerinin 1974-2019 yılları arası ARDL sınır testi ile Türkiye’de yenilenebilir enerji yayılımı üzerinde etkileri araştırılmaktadır. ARDL kısa dönem sonuçlarına göre; bütün değişkenler yenilenebilir enerji kaynaklarının yayılımını olumsuz etkilerken, uzun dönem de ise beşerî sermaye, gelir düzeyi yenilenebilir enerji yayılımını olumlu etkilemesine karşın, belirsizlik ve küreselleşme olumsuz etkilemektedir.
Monitoring Heater pada Inkubasi dengan Android
Authors: Hafidin Hafidin
Published: April 2022

Incubator digunakan untuk memanaskan sample, alat ini bekerja dengan menggunakan heater penggunaan incubator masih mempunyai kendala pada sistem monitoring heater pada incubator. Sehingga penelitian ini memfokuskan pada sistem Android. Tujuan penelitian ini memberikan kemudahan pada penggunaan dan tenaga kesehatan dalam monitoring kondisi suhu alat yang mana alat ini bekerja secara otomatis dan dapat dipantau pembacaan suhu sesuai dengan settingan yang diinginkan user. Metode penelitian yang digunakan yaitu dengan mengambil darah dari pasien terlebih dahulu lalu diinkubasi. Kemudian hasil dari inkubasi tersebut harus dilakukan monitoring dengan cara user memeriksa kondisi suhu pada incubator apakah stabil atau tidak melalui smartphone yang telah terinstal aplikasi Android Blynk tanpa harus mengecek langsung ke modul penelitian. Pada pengujian suhu 37 C pada modul penelitian diperoleh nilai rata-rata 36,5 C tetapi ada perbedaan suhu sebesar 0,5 C dari suhu yang diatas tetapi masih dalam batas toleransi. Hasil akhir dari penelitian ini adalah menampilkan pembacaan suhu dan waktu pada alat berdasarkan suhu dan waktu yang ditentukan yang dapat dipantau pada smartphone.
Rancang Bangun Prototipe Pemanen Energi Getaran pada Speed Bump Menggunakan Tranducer Piezoelectric
Authors: Pratama Legenda Prameswono , Herdiyansyah Rizal Agus , Manfaluthy Mauludi
Published: April 2022

Listrik adalah salah satu aspek penting bagi manusia untuk menjalankan segala kegiatan sehari-hari. Seiring dengan terus meningkatnya jumlah penduduk, maka kebutuhan akan pemakaian energi listrik juga semakin meningkat. Namun, sebagian besar konsumen energi listrik masih mengandalkan PLN (Perusahaan Listrik Negara), sehingga diperlukan banyak inovasi di bidang ketenagalistrikan, terutama energi alternatif yang ramah lingkungan. Dengan memanfaatkan jumlah penduduk yang terus meningkat tiap tahunnya, maka dibuatlah alat yang dapat mengkonversikan energi tekanan dari kendaraan sepeda motor manjadi energi listrik. Metode yang digunakan didalam penelitian ini adalah metode eksperimental. Studi ini telah berhasil mengintegrasikan teknologi daur ulang energi dalam sebuah konsep pemanenan energi menggunakan tranduser piezoelectric  yang divalidasi menggunakan 200 kali pijakan pada prototipe speed bump. Dari total 200 kali pijakan pada speed bump tegangan yang disimpan pada ACCU terus mengalami kenaikan tetapi tegangan yang dihasilkan oleh piezoelectric  terus mengalami penurunan pada 50 pijakan pertama yaitu penambahannya sebesar 1,1V dimana tegangan ACCU awal adalah 3,4 V menjadi 4,5 V, dipijakan ke 100 penambahan tegangan masih stabil yaitu sebesar 1,1 V, dipijakan ke 150 mulai terjadi penurunan interval yaitu menjadi 0,9V, dipijakan terakhir yaitu pijakan ke 200 terjadi lagi penurunan yaitu menjadi 0,5 V.
Rancang Bangun Medicooler Insulin Berbasis Atmega16
Authors: Fajrin Hanifah Rahmi , Hamdu Malik S Rilda Gigan , Handoko Brama Sakti
Published: April 2022

Pada dasarnya, lingkungan penyimpanan insulin membutuhkan waktu dan kondisi suhu yang stabil dengan kisaran suhu 15 °C hingga 20 °C untuk menjaga kualitasnya. Pada penelitian ini akan dibuat alat penyimpan insulin berupa medicooler dengan menggunakan elemen Peltier sebagai penghasil dingin dan aluminium sebagai media penghantar dingin. Metode pengumpulan data dilakukan dengan mengukur suhu menggunakan dua termometer pembanding, yaitu termometer 1 untuk mengukur suhu dalam box dan termometer 2 untuk mengukur suhu dalam cairan yakult (pengganti insulin) dengan menggunakan set point 17°C. Dari hasil pengujian didapatkan nilai error termometer 1 dengan error 1%, nilai error termometer 2 kurang dari 2%. Dapat disimpulkan bahwa alat ini dapat digunakan sebagai tempat penyimpanan insulin.
A role of biomarkers in systemic lupus erythematous: a comprehensive review
Authors: Jindam Shashank , Koraseeka Pranav , Addagarla Suvarna , Gelly Ramya B. P.
Published: April 2022

Systemic lupus erythematous (SLE) is an auto immune disease that can involve almost all body organs. Lupus erythematous may be classified in to several subtypes according to clinical features including systemic and cutaneous lupus erythematous, drug induced lupus and neonatal lupus. SLE progression includes in the immune system. Pathological manifestation of SLE are due to antibody formation and deposition of immune complexes in different organs of the body. Due to formation or disposition of immune complex in different body tissues and vessels, which may lead to complement activation and more organ damage. Other factors include genetic factors, hormonal abnormalities and environmental factors. There is a challenge in establishing a diagnosis, determining disease activity. Therefore, an important needs is a repertoire of biomarkers that can accurately with prediction, diagnosis, and disease, activity monitoring and stratifying patient. SLE can be diagnosed by using different biomarkers as anti-smith antibodies (ANAS), antibodies to double stand deoxyribonucleic acid (DNA) and level of complement components C3 C4, and CH50. More immunological biomarkers are needed to be better understanding of disease SLE. SLE is an autoimmune disease which can travel to any organ or a system i.e. biomarkers for cardiovascular involvement in SLE, biomarkers for respiratory involvement in SLE, biomarkers for lupus arthritis.
Inmazeb: new hope for Zaire Ebola virus disease
Authors: Garg Richa
Published: April 2022

Ebola virus disease first appeared in 1976 in Zaire (now democratic republic of Congo). Since then virus outbreaks occurred periodically in African countries. The cases notified in March 2014 in west Africa was largest outbreak till now. In 2020 there is ongoing outbreak of Zaire Ebola virus in democratic republic of Congo. Ebola virus is single stranded RNA virus which causes viral hemorrhagic fever in humans presenting as high fever, chills, loss of appetite, myalgia, headache. Till now there was no specific treatment, symptomatic treatment methods including infusion of electrolyte and/or antibiotics were mainly used. In October 2020 FDA approved the first treatment for Zaire Ebola virus disease in adult and pediatric patients, including neonates born to a mother who is RT-PCR positive for Zaire ebolavirus infection. The treatment is called Inmazeb, combination of three recombinant human IgG1κ monoclonal antibodies (Atoltivimab, Maftivimab, and Odesivimab-ebgn) each targeting the Zaire ebolavirus glycoprotein.
Molnupiravir: a new hope in the treatment of COVID-19
Authors: Paudel Rama
Published: April 2022

Coronavirus disease-19 (COVID-19), a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been causing pandemic since its first emergence in Wuhan, China in December 2019.1 Most of the people with COVID-19 experience mild to moderate respiratory illness and recover without requiring special treatment. The common presentations of the disease include fever or chills, cough, shortness of breath or difficulty breathing, fatigue, muscle or body aches, headache, new loss of taste or smell, sore throat, congestion or runny nose, nausea or vomiting and diarrhea.2 However, upto 20% patients develop severe disease requiring hospitalization.3 Older adults and people with underlying medical conditions like heart or lung disease or diabetes are at higher risk for developing more serious complications such as pneumonia, acute respiratory distress syndrome, cardiac injury, arrhythmia, septic shock, liver dysfunction, acute kidney injury, multi-organ failure and death of the patients.2,4 The pandemic has presented a major threat to public health worldwide. As of 13 March 2022, World Health Organization (WHO) reported a total of 452,201,564 confirmed cases of COVID-19 with 6,029,852 deaths (case fatality: 1.33%).5
Threat of multidrug resistant bacterial pathogens in COVID-19 pandemic
Authors: Nepal Hari Prasad , Paudel Rama
Published: April 2022

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease first emerged in Wuhan, China in December 2019 and since then, has been spreading worldwide.1 On March 11, 2020, the World Health Organization (WHO) declared the disease a pandemic.2 This pandemic has been described as the greatest threat to global health since the Spanish Influenza pandemic in the 20th century.3
Weight loss methods and diet history among bariatric surgery candidates
Authors: Vertiz Lizbeth Guilbert , Sahagún César Manuel Vargas , Guerrero Elisa Maria Sepúlveda , Licona Carmen Georgina Castelán , Escobedo Sergio Ulises Pérez , Zerrweck Carlos
Published: April 2022

Background: Nowadays there are multiple conservative treatments, medical and alternative for weight loss, with high failure levels in patients with obesity. The history of variability, effectiveness, and diversity of such treatments has been poorly explored in candidates to bariatric surgery, particularly in Latin America, where high rates of overweight and obesity are found.Methods: Cross-sectional study in a single center, where a questionnaire was given to all patients who presented for bariatric surgery evaluation. The primary objective was to identify the dietary history and methods used for weight loss in patients with obesity, focusing in the diet type/method, length, effectiveness, and weight regain. Also, a basal anthropometric/demographic analysis, and type of method used (diet, medications, homeopathy, supplements, and alternative therapies) was performed.Results: 400 questionnaires were evaluated, from which the average age was 40.2 years, 79.5% representing female sex, and an average weight of 114.8 kg. Childhood obesity was reported in 38%. 64.5% used among 1-5 methods to lose weight historically, but 74.7% never associated physical activity. Supervised diet (with and without medication) was the most effective method (44% of cases used medication); however, they were discontinued in 50.5% due to adverse effects.Conclusions: The use of a diet or alternative treatments, with or without medications, have shown poor weight loss and minimum durability. The use of medication is very common, but most people discontinue their use due to adverse effects events.
Comparing the effects of alternate day and daily thyroxine replacement therapy in subclinical hypothyroidism
Authors: Mishra Sanjay , Gupta Arjit
Published: April 2022

Background:  Subclinical hypothyroidism (SCH) is defined as serum thyroid-stimulating hormone (TSH) level above upper limit of normal despite normal levels of serum free thyroxine.  According to recommendations, L-thyroxine treatment for hormone replacement therapy should be continued on daily basis. However, some trials have challenged daily regimen for management of hypothyroidism and have suggested dosage scheduling at weekly, twice-a-week or alternate day as possible alternatives having similar effect as for daily regimen.Methods: Study was prospective randomized cross-over intervention design.  Thyroid functions (T3, T4 and TSH) were measured using third generation non-isotopic immunochemiluminescence method using standard protocol. 120 patients with clinically established hypothyroidism were enrolled in study.Results: Difference in mean TSH levels of group I and group II were not found to be statistically significant at baseline (8.247±2.288 mIU/ml versus 8.210±2.650; p=0.935), at 6 weeks (2.337±1.792 mIU/ml versus 2.843±2.410 mIU/ml; p=0.195) and at 12 weeks (2.508±1.180 mIU/ml versus 2.831±1.200 mIU/ml; p=0.191). Difference in mean T3 levels of group I and group II were not found to be statistically significant at baseline (1.118±0.199 ng/dl versus 1.184±0.187 ng/dl; p=0.061), at 6 weeks (1.266±0.295 ng/dl versus 1.196±0.289 ng/dl; p=0.192) and at 12 weeks (1.121±0.211 ng/dl versus 1.179±0.203 ng/dl; p=0.174). Difference in mean T4 levels group I and group II were not found to be statistically significant at baseline (8.422±2.054 µg/dl versus 7.899±2.333 µg/dl; p=0.196), at 6 weeks (8.852±2.836 µg/dl versus 8.533±2.672 µg/dl; p=0.527) and at 12 weeks (8.159±2.235 µg/dl versus 7.990±2.463 µg/dl; p=0.728).Conclusions: The findings of present study show that alternate day L-thyroxine is a viable solution for the management of SCH.
Estimation of extra-pancreatic necrosis volume and its correlation with the clinical outcome in acute pancreatitis
Authors: Thapa Manish , Sharma Pankaj , Ram Birma
Published: April 2022

Background: The aim of study was to measure extra-pancreatic necrosis volume in acute pancreatitis and associate with the clinical outcome and to determine the threshold volume of extra-pancreatic necrosis that predicts severity of acute pancreatitis.Methods: Hospital based observational study was carried out in the department of radiodiagnosis, Armed forces medical college, Pune, Maharashtra. All cases referred for CT scan in suspected cases of acute pancreatitis (by clinical and/or biochemical parameters) as a part of institutional protocol were included in the study. Multiplanar reconstruction with volumetric analysis was done for measuring the extra-pancreatic necrosis volume (EPNV) using inherent CT scanner volume assessing software.Results: Out of total 41 patients studied, more than one cause was identified in 9 patients. The most common cause of acute pancreatitis was alcohol use 32 (64%), followed by gallstone and diabetes mellitus (8% each). There was a positive correlation between EPNV and duration of hospitalization which was statistically significant with Spearman's correlation coefficient of 0.579 and p<0.001.Conclusions: Our study showed highly significant correlation between the EPNV and the prediction of end organ failure, systemic infection, duration of hospital stay and need for intervention. Statistically patient presenting with EPNV of more than 100 ml was closely associated with end organ failure; hence EPNV may be used as a useful scoring system. This study has highlighted the convenient and easier technique of predicting clinical outcome in patient by simply assessing the severity of acute pancreatitis by measuring EPNV.
Effect of obesity on cognitive function: a cross-sectional study
Authors: Gandhi Piyush P. , Humaney Nalini R.
Published: April 2022

Background: Obesity is the leading cause of many health problems. It mostly affects the brain by cerebrovascular events, but since it is a chronic low-grade inflammatory state, inflammatory cytokines in blood alter neuronal function. The jolly-fat hypothesis says that obese people have better cognition as they have more fat storage which is required to make neurotransmitters. Many studies have been done to support each of the above hypotheses but most are done in the paediatric or geriatric populations which can have other confounding factors. Obesity can be easily treated with proper dietary interventions, exercise, pharmaceutical therapies, or surgical interventions. Thus, it was worth exploring as simple lifestyle changes might lower the incidence of cognitive disabilities.Methods: This study was done on undergraduate medical students with a sample size of 120 (60 male and 60 female). Their body mass index was calculated after taking body weight and height. The cognition of subjects was studied using the Washington click reaction time test. This was correlated with body mass index using a t test to find a p value with a level of significance of 0.05.Results: High body mass index is associated with poor cognition as the p<0.05 (0.025006). There was no role of gender on body mass index or cognitive functions.Conclusions: Obesity does affect the cognitive function in healthy adult populations with no comorbidities irrespective of the gender of the individual. More prospective studies with a more sensitive battery of tests can be done to further understand this.
Urinary bladder paraganglioma: a clinical dilemma in diagnosis and management: our experience at a tertiary care center
Authors: Kriplani Akshay , Jain Deep , Kulshreshtha Mayank , Jayadeva Reddy Suraj , Pandit Shruti , Reddy Bathi Sourabh , Sachdev Gurvansh Singh , Hiremath Vivekanand Kedarlingayya , Chawla Arun
Published: April 2022

Urinary bladder paraganglioma (UBP) are rare neuroendocrine tumors with variable biological behavior. High index of suspicion in the preoperative evaluation would enable the clinician to formulate appropriate management of the rare tumors. Clinical and pathological data of seven cases evaluated and treated as per a devised protocol for suspected bladder paraganglioma from 2008 to 2019 was retrospectively reviewed. Among the seven cases, UBP’s were predominantly seen in middle aged men. Most of these presented with storage symptoms (85.71%; n=7) and gross painless hematuria (42.85%; n=3). Three patients were hypertensives and post-micturition syncope was seen in two patients. Among the seven patients two patients had functionally active tumors confirmed by elevated urinary and serum markers for catecholamine excess. Functional tumors, nonfunctional tumors involving uretero-vesical junction or broad based polypoidal tumor were considered for partial cystectomy. Other small nonfunctional tumors underwent trans-urethral resection of bladder tumour (TURBT). Follow up protocol included repeat ultrasound, check cystoscopy and completion TURBT at one month and annually thereafter. Repeat urinary catecholamines at 1 month was done in functional UBP. Cystoscopic examination of a bladder lesion which are solid, sessile and predominantly intramural, a prior to a definitive planned surgery may differentiate UBP from urothelial cancer. Most of the non-functional UPB are diagnosed by histopathological examination.  In symptomatic cases, functional evaluation with biochemical estimation of catecholamine excess allow better treatment planning and avoiding intraoperative hemodynamic instability. Due to high recurrence rate life-long follow-up despite complete excision is strongly recommended.
Transverse colorectal anastomosis in left-sided colorectal stapled anastomosis and risk of anastomotic leak: a single tertiary centre experience
Authors: Muthukumarasamy Navinakathiresu , Ren Stanley Eng Chee , Henry Fitzgerald
Published: April 2022

Background: Extensive left colorectal resection following a high IMA ligation can lead to an anastomosis with tension and a compromised perfusion. The aim of this study is to compare the safety and feasibility of transverse colorectal anastomosis in anastomotic leak (AL) following left-sided colorectal stapled anastomosis with a descending colon/ileo – rectal anastomosis.Methods: This retrospective study was performed in a prospectively maintained database at a tertiary colorectal surgical institution in Malaysia to evaluate the impact of performing a transverse colon to rectal anastomosis in a group of patients who underwent left-sided colorectal resection followed by stapled anastomosis from 2019 until 2021. This was compared to another cohort comprising of patients who underwent descending colorectal/ileo-rectal anastomosis. Categorical and dichotomous variables were analysed using chi squared test. Results which were considered significant were if p<0.05. The statistical analysis was performed with IBM Statisticalpackage for social sciences (SPSS) statistics for Mac OS, version25.Results: In that 3 years, 170 patients were included. 77 (45.3%) underwent transverse colorectal anastomosis. The median age of these patients was 58.5. Both groups of patients who underwent transverse colorectal anastomosis and ileo/colorectal anastomosis was homogenous with no significant difference. Our anastomotic leak rate was 8.8% (n=15). 48.8% (n=83) successfully completed their resections laparoscopically. And from our analysis, transverse colorectal anastomosis does not significantly affect anastomotic leak rates (p=0.22)Conclusions: In an experienced tertiary health centre, transverse colorectal anastomosis does not impact anastomotic leak rate and has comparable outcomes to descending colon/ ileo-rectal anastomosis.