bluuebunny/crossref_metadata_2025 huggingface dataset:
Usage of meat and bone meal in animal, poultry and fish feeds: A survey and risk analysis for the occurrence of Bovine Spongiform Encephalopathy in Bangladesh
Authors: Islam Dr. Md. Nazrul , Siddiqui Dr. Md. Saiful , Islam Dr. Md. Rafiqul , Chowdhury Emdadul Haque
Published: March 2022

Background: Bovine Spongiform Encephalopathy (BSE) is an emerging
zoonotic disease of cattle associated with prion protein (PrPsc)
transmitted via meat and bone meal (MBM). Although Bangladesh did not
experience a BSE outbreak but the country could not export animal
products to developed countries as has not yet been declared BSE free
country by OIE due to lack of scientific risk evaluation for BSE. The
objectives was identification of hazard, release and exposure pathways
of prion protein through MBM and analysis of risk for the occurrence of
BSE in Bangladesh. Methods: The scientific data were reviewed, hazards
were scheduled and surveys were conducted - on livestock production
system, import of MBM and its use to identify the hazards present in
Bangladesh context. The analysis was done by the “OIE Risk Analysis
Framework 2006 and European Union (EU) Scientific Steering Committee
(SSC) 2003”. From the historical reviews, import of MBM and its use was
identified, as external hazards. Results: The analysis revealed that,
this hazards had negligible or moderate risk, for the introduction of
infectious PrPsc as Bangladeshi cattle are vegetarian cattle. No milk
replacer was used and use of slaughtered waste in the animal feed
industry is absent. Un-consumable bones are processed to produce bone
chips, fertilizers and bone meal for poultry feeds. Scrapie was never
prevalent in Bangladesh. Therefore, risk from the internal challenge was
negligible in Bangladesh for the occurrence of BSE. This prevented the
propagation of BSE infectivity and eliminated BSE infectivity from the
system very fast, if that was present. Conclusion: It was concluded
that, introduction of PrPsc into cattle population of Bangladesh through
MBM was very negligible. Key Words: MBM, risk assessment, risk analysis,
BSE
Right Ventricular Outflow Tract Tachycardia in a COVID-19 Patient: A Case Report and Review of the Literature
Authors: Hallak Yusuf , Battistin Umberto , Hasan Ahmedyar , Alsmadi Montaser , Hallak Fatima , Butt Mehmood
Published: March 2022

Objectives: The novel Coronavirus (SARS-CoV2) adversely affects cardiac
status and may cause arrhythmias. The objective of this study is to
describe the case of a 41 year-old female presenting to the emergency
department with Right ventricular outflow tract (RVOT) ventricular
tachycardia; as well as to appraise and compare etiologies proposed in
the literature with our case. Methods: The study design is a case report
and review of the literature. A PubMed/Medline search was conducted
including studies published in peer-reviewed journals between December,
2019 and November, 2020. Papers discussing the relationship between
COVID-19 and cardiac arrhythmias were included, excluding the pediatric
population and papers with major confounding factors to the
predisposition of cardiac arrhythmias. Results: 6 papers were included
in the qualitative synthesis. These papers discussed different
mechanisms by which COVID-19 can cause arrhythmias. These results were
compared with the findings in our case in an attempt to better
understand the etiology behind our case of RVOT-VT. Proposed etiologies
included ACE2-mediated direct damage of cardiomyocytes, raised serum CRP
levels, and raised systemic inflammatory markers and activation of the
Ca2+/Calmodulin protein kinase I. Conclusion: The lack of associated
comorbidities and risk factors in our patient highlights the unique
challenge of identifying the clinical sequelae of COVID-19. Proposed
pathophysiologies in the literature were not applicable to our case,
highlighting the need for clinical monitoring in patients, and the need
for further research on the topic.
Uniqueness of solution for a nonlinear heterogeneous evolution dam problem
Authors: Attia Messaouda Ben , Zaouche Elmehdi , bousselsal mahmoud
Published: March 2022

By choosing convenient test functions and using the method of doubling
variables, we prove the uniqueness of the solution to a nonlinear
evolution dam problem in an arbitrary heterogeneous porous medium of
IR^n (n≥2) with an impermeable horizontal bottom.
The muscle bundle approach for catheter ablation of the cavotricuspid isthmus: a propensity score-matched cohort study
Authors: Alvarez Miguel , Jordán Laura , Ballesteros Guillermo Gutierrez , Macias-Ruiz Rosa , Lerma Manuel Molina , Sánchez-Millán Pablo , Jiménez-Jáimez Juan , Rivera-López Ricardo , Tercedor Luis
Published: March 2022

Introduction Pathological studies have demonstrated that the
cavotricuspid isthmus (CTI) is often composed of discrete muscle bundles
that correlate with high-voltage local electrograms. The main objective
was to demonstrate that ablation of high-voltage muscle bundles in the
cavotricuspid isthmus (CTI), identified using an intracardiac mapping
system, reduces radiofrequency (RF) time compared to the conventional
technique. Methods A retrospective analysis of patients who had
undergone CTI ablation guided by a mapping system. The patients were
divided into two groups according to operator experience and selected by
propensity score-matched analysis: group A, RF delivery in high-voltage
bundles and group B, RF delivery producing a contiguous line of ablation
lesions along the entire CTI length. Results Thirty-eight patients
[92.1% male, 64 yrs (57-70)] were selected, 19 in each group. There
were no differences in baseline characteristics or clinical results:
success (A: 94.7% vs B: 94.7%), complications (A: 5.3% vs B: 0%) and
recurrence (A: 10.5% vs B: 5.3%). In the procedures in group A, fewer
RF applications were delivered [14 (9–19) vs 20 (2–25);
P < 0.05] with greater contact force [14.5 g (13–16.2) vs
12 g (9-14); P < 0.01] and greater lesion size index (LSI)
[5.3 (4.9–6) vs 4.5 (4.1–4.7); P < 0.001]. The RF time
was less (P < 0.001) in group A [310 s (211–479) vs 577 s
(312–858)]. Conclusions Application of RF in CTI muscle bundles
reduces RF time, compared to conventional linear ablation, with similar
clinical results.
The lost superior vena cava: advancement in leadless pacemaker usability
Authors: Morani Giovanni , Moretti Marina , Bolzan Bruna , Puntel Gino , Ribichini Flavio
Published: March 2022

A 70-year-old man affected by a metastatic lung adenocarcinoma developed
an atrioventricular block. Due to an extensive thrombosis of the
superior vena cava with invasion of the right atrium, a traditional
transvenous pacemaker system (TTPS) implantation was not feasible.
Despite the extensive development of the thrombosis in the right atrium,
the patient successfully underwent Micra transcatheter pacing system
(MTPS) implantation. This case report describes a quite rare condition
in which a leadless pacemaker (LP) is the best option to treat an
atrioventricular block and where the recent introduction of the
groundbreaking AV MTPS would be the optimal therapy.
Albumin - globulin ratio and Eosinophil-neutrophil ratio as potential predictive biomarkers for Anti-PD-1/PD-L1 treatment in advanced malignant tumors.
Authors: Ma Yan , Shang Kun , Wu Shanshan , Wang Jing , Cao Bangwei
Published: March 2022

Purpose To investigate the predictive value of peripheral serum
biomarkers such as albumin - globulin ratio (AGR) and eosinophilic -
neutrophil ratio (ENR) in the advanced malignant tumors with
anti-PD-1/PD-L1. Methods We retrospectively analyzed the clinical
efficacy of 95 patients with advanced metastatic malignancies treated
with PD-1/PD-L1 inhibitor from January 1, 2017 to May 1, 2020 in our
cancer center. The predictive value of baseline AGR, baseline ENR,
baseline neutrophil-lymphocyte ratio (NLR) and other serum biomarkers
was evaluated. We also develop a risk scoring tool and draw a Nomogram.
Results The disease control rate was 64.2%, and the median
progression-free survival(PFS) was 108 days. Univariate COX analysis
showed that age, NLR, Eastern Cooperative Oncology Group (ECOG)
performance status (PS), platelet-neutrophil ratio (PLR), ENR, AGR),
LDH, treatment lines, and treatment were closely correlated with PFS.
Multivariate COX analysis showed that age, AGR, ENR, and treatment were
independent prognostic factors for PFS. The low-risk group
(-4~0 points) had significantly higher PFS than the
high-risk group (1~3 points) when the risk scoring tool
was constructed based on COX regression model. The Nomogram Concordia
Index (C-index) with independent prognostic factors was 0.716.
Conclusions Baseline AGR and baseline ENR may be effective biomarkers
for predicting the efficacy of anti-PD-1/PD-L1 in the advanced malignant
tumors, and their clinical value needs to be verified by further
large-sample and prospective studies.
Unusual Clinical Behavior of a Very Late Retinoblastoma Relapse in a Patient with a Germline RB Mutation
Authors: Persaud Yogindra , Seddiq Marjilla , Wu Yi-Mi , Robinson Dan , Janet Poulik , Sood Sandeep , Altinok Deniz , ROARTY JOHN , Geller James , Mody Rajen , Taub Jeffrey
Published: March 2022

Retinoblastoma is the most common ocular tumor of childhood with cure
rates exceeding 95%. Patients with high-risk features typically relapse
within 3 years of diagnosis. We report a patient with low-risk bilateral
retinoblastoma who suffered systemic relapse after eight years. His
disease at first relapse was chemosensitive without PET avidity or bone
marrow disease following therapy. Six months later, he experienced an
isolated CNS relapse and succumbed to refractory disease. “Oncoseq”
exome sequencing confirmed the presence of germline RB mutation among
all tissues as well as somatic changes which may provide insights into
the biology of relapse and tumor.
Slip flow between co-rotating disks with heat transfer
Authors: Turkyilmazoglu Mustafa
Published: March 2022

The current research addresses hydrodynamic and thermal solutions of the
incompressible fluid flowing through uniformly co-rotating disks of
finite radii. The narrow gap between the disks necessitates the
consideration of slip flow in the radial direction, rather than the
classical no-slip model. Perturbation approach is adopted and full
analytical approximations from the Navier-Stokes and energy equations
are derived up to the second-order, otherwise numerical effort is
required for higher level truncations, owing to the lengthy and complex
expressions. In the absence of slip, the momentum solutions are shown to
match perfectly with those available in the literature. The convergence
of series solutions with slip is then demonstrated through some
selection of parameter set. The main conclusion is that slip and
Reynolds number lead to reduction in the momentum and thermal layers,
with more cooled disk surfa
A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetric cholestasis.
Authors: Mohan Manoj , Prabhu Sanjay , Pullatayil Abdul , Lindow Stephen
Published: March 2022

Objective To determine the prevalence of gestational diabetes in women
with obstetric cholestasis. Design Systematic review and meta-analysis
of data published since 2010. Selection Observation studies with
quantifiable data. Sample A total of 16748 patients with obstetric
cholestasis from 21 studies were included. Methods A pre-defined
protocol with extensive literature search plus other sources to obtain
all possible articles was followed. All articles were evaluated and
included in the study with specified criteria for the risk of bias using
the Newcastle Ottawa Score. A meta-analysis was performed with MOOSE
specifications met. Main Outcome measure Prevalence of gestational
diabetes in the obstetric cholestasis population. Results The prevalence
of gestational diabetes in the obstetric cholestasis population was
13.9% (20 studies analysed). Gestational diabetes was seen more in the
obstetric cholestasis group compared to the non-obstetric group (OR
2.129, 95%CI, 1.697 to 2.670,10 studies). Severe cholestasis has more
gestational diabetes cases (OR 2.168, 95% CI, 1.429 to 3.289, 4
studies) compared to mild cholestasis. Conclusion There is a significant
co-relation of gestational diabetes among the diagnosed obstetric
cholestasis population. With a diagnosis of obstetric cholestasis is
made, it is necessary to test for undiagnosed gestational diabetes
further. This approach may reduce the risk of stillbirth in severe
obstetric cholestasis cases. PROSPERO Registration number CRD42021223886
Some Results for Fuzzy Dominated Maps and Related Applications in Graph Theory, Integral Equations and Functional Equations in Dynamic Programming
Authors: Rasham Tahair , Shahzad Aqeel , Marino Giuseppe , Shoaib Abdullah
Published: March 2022

This paper is devoted to find out some realization of the concept of
b-metric like space. First, we attain a fixed point for two fuzzy
mappings satisfying a suitable requirement of contractiveness.
Subsequently, we apply such result to graphic contractions. Also, we
attain a unique solution for a system of integral equations and lastly
we give an application to ensure that there exists a common bounded
solution of a suitable functional equation in dynamic programming.
Liquiritigenin, an active component of Xin Su Ning, inhibits hERG channel conductance in a bisigmoidal fashion
Authors: Sweeney Owen , Wang Taiyi , Ellory Clive , Wilkins Robert , Ma Yuling
Published: March 2022

Background and Purpose: Xin Su Ning (XSN) is a multi-herbal
anti-arrhythmic medicine with strong clinical evidence endorsing its
safety, tolerability and efficacy. The medicine contains over 70
identified active components, and the mechanisms of many are yet to be
fully understood. In silico modelling has identified several compounds
likely to be of pharmacological significance, one of which is
Liquiritigenin (LTG). Experimental approach: To investigate the LTG’s
mechanism on cardiac ion channels and to assess the compound’s broader
anti-arrhythmic contribution to XSN, whole cell patch clamp experiments
were carried out on a CHO cell line stably transfected to express hERG
K+ channels. Key Results: LTG weakly inhibited the peak conductance of
the channel with unusual bisigmoidal kinetics. Performing channel
activation and inactivation kinetics experiments showed that at very low
concentrations, LTG bound to the open hERG channel and antagonised hERG
activation without affecting inactivation. Only at very high
concentrations was hERG inactivation potentiated and channel conductance
completely inhibited. Conclusions and Implications: This study suggests
LTG may bind to multiple hERG channel sites and modulate channel
activity to give an anti-arrhythmic effect.
WHO AWaRe strategy and antimicrobial stewardship to combat antimicrobial resistance: An Indian perspective
Authors: Meena Dinesh , Mathaiyan Jayanthi
Published: March 2022

Antimicrobial resistance is a serious problem to solve especially in
developing countries like India. Antibiotic use in India increased
several times since 2005. Many studies in India have reported
inappropriate and overuse of antibiotics which could be one of the
possible reasons for increased antibiotic resistance in country. This is
an important and urgent issue that mandate strict regulations regarding
rational use of antibiotics. World Health Organization (WHO) has done
major revision in essential medicines list which classify antibiotics in
three categories (access, watch and reserve) to ensure the availability
and correct use of antibiotics. Several countries started antimicrobial
stewardship programme to promote appropriate use of antibiotics, reduce
antibiotic resistance as well as financial burden. Indian government
implemented national action plan on antibiotic resistance in 2017 with
the aim of prompting rational use of antibiotics but it is still in its
formative stage as all stewardship components are yet to be implemented.
This review emphasizes on the importance and the need for implementing
WHO’s AWaRe classification and antimicrobial stewardship to promote
rational antibiotic use in country.
Determination of a criminal suspect using environmental plant DNA metabarcoding technology
Authors: Liu Yanlei , Xu Chao , Dong Wenpan , Yang Xueying , Zhou Shi-Liang
Published: March 2022

There are criminal cases that no frequently used evidence, for example,
DNAs from the criminal, is available. Such cases usually are
unresolvable. With the advent of DNA metabarcoding, evidences are mined
from environmental DNA and such cases become resolvable. This study
reports how a criminal suspect was determined by environmental plant DNA
metabarcoding technology. A girl was killed in a rural wet area in China
without a witness or video record. Pants with dried mud was found from
one of her boyfriend’s house. The mud was removed from the pants and 11
more mud or soil samples surrounding murder scene were collected. DNA
was extracted from the soil. Chloroplast rbcL gene fragments were
amplified and sequenced on a next generation sequencing platform. Of the
2980 ZOTUs in total from the 12 samples, 1495 ZOTUs were identified to
species, genera or families based on the existing public database. The
feast analysis based on either taxa or taxa plus abundance data
demonstrated that the mud on the suspect’s pants was from the criminal
scene. The suspect finally made a clean breast of his crime. This case
implies that plant DNA in the environment soil is a new source of
evidence in determination of suspects using DNA metabarcoding technology
and has high potentials of extensive applications in criminal cases.
COVID-19 in a case of Toxic Epidermal Necrolysis
Authors: Shahidi-Dadras Mohammad , Shahri-Gharahkoshan Shaghayegh , Yazdi Esmat , Fatemi Alireza , Mahboubi-Fooladi Zahra , Dadkhahfar Sahar
Published: March 2022

The COVID-19 pandemic is a major health issue and patients with
underlying conditions are more susceptible to catastrophic outcomes.
Toxic epidermal necrolysis (TEN) is a severe systemic disease caused by
immune system hypersensitive reaction. We present a case of TEN that
later complicated with COVID-19,Deep Vein Thrombosis(DVT),Pulmonary
Emboli(PE),and death.
Diagnostic performance of rapid antigen test for COVID-19 and the effect of viral load, sampling time, subject's clinical and laboratory parameters on test accuracy
Authors: Amer Rania , Samir Mohamed , Gaber Osama , EL-Deeb Nahawand , Abdelmoaty Ahmed , Ahmed Alshymaa , Samy Walaa , Atta Amal , Walaa Mohammed , Anis Reham
Published: March 2022

The ongoing COVID-19 pandemic has highlighted the central role of
diagnostic tests in pandemic control. Although reverse transcriptase
quantitative real-time PCR (RT-qPCR) is the gold standard for the
diagnosis of COVID-19, several rapid antigen tests (RAT) have been
commercialized as rapid point-of-care diagnostics. To the best of our
knowledge, there are limited data on the effect of patient’s clinical
and laboratory parameters on RAT performance and no studies exist that
tested the importance of combining laboratory measurements in patient’s
blood in enhancing the performance of RAT. Here we tried to fill these
gaps by evaluating the diagnostic performance of the RAT “Standard ™ Q
COVID-19 Ag” in participant’s subgroups studying the influence of viral
load, sampling time-post symptoms, clinical and laboratory features on
test performance. Eighty-three nasopharyngeal and oropharyngeal swabs
were tested for sever acute respiratory syndrome-coronavirus 2
(SARS-CoV-2) by both RT-qPCR and RAT. Diagnostic accuracy of the RAT was
evaluated for participant’s subgroups that have various features.
Support vector machine model was then used to investigate whether
laboratory measurements in subject’s blood would enhance the predictive
accuracy of this RAT. The sensitivity, specificity and accuracy of the
RAT were 78.2, 64.2 and 75.9%, respectively. Samples with high viral
load and those that were collected within one week post-symptom showed
the highest sensitivity and accuracy. Measuring Laboratory indices did
not enhance the predictive accuracy of this RAT. It is concluded that
“Standard ™ Q COVID-19 Ag” should not be used alone for COVID-19
diagnosis due to its low diagnostic performance. This RAT is best used
at early disease stage and in patients with high viral load.
Knowledge Enhancement and Understanding of Diversity
Authors: Tiwari Siddhartha Paul
Published: March 2022

In many societies, diversity has been neglected. The importance of diversity in the society for knowledge generation has become increasingly apparent in recent years. In order to achieve diversity, we need to take into account people from various backgrounds and backgrounds, and to understand that every individual is unique. Differentiating people can be based on race or ethnicity, nationality, age, gender, sexual orientation, economic background, and disabilities. We must recognize that each of these differences results in different experiences for individuals, and that all of these experiences can be synthesized to generate knowledge that is both more inclusive and more comprehensive. Diverse initiatives can be used to promote diversity in educational institutions, such as affirmative action and diversity programs. As diversity enhances receptivity to learning from others’ experiences, it is essential for creativity and innovation. Furthermore, diversity promotes productivity and performance as a team can draw on the experience of each individual to find solutions to problems. Individuals must be aware of different opportunities and possibilities in order to grow as individuals, and diversity allows this to happen. As diversity prepares individuals for a diverse world, it is also important to students’ learning. Ultimately, diversity contributes significantly to the creation of new knowledge due to the fact that it helps people draw on their own experiences and the experiences of others in order to discover new approaches to problems.
The effect of the plasma methotrexate concentration during high-dose methotrexate therapy on prognosis of childhood acute lymphoblastic leukemia
Authors: Liao Chan , Xu Xiao-Jun , Zhang Jing-Ying , Song Hua , Xu Wei-Qun , Shen He-Ping , Shen Di-Ying , Zhao Fen-Ying , Liang Juan , Tang Yong-Min
Published: March 2022

Aim: High-dose methotrexate (HD-MTX) therapy is commonly used in acute
lymphoblastic leukemia (ALL) which need drug monitoring. This study was
to analyze the influence factors and prognostic role of the plasma MTX
concentration in ALL. Methods: 1435 HD-MTX courses of 246 childhood ALL
were enrolled. MTX doses were 3 g/m2 for low-risk (LR) group and 5 g/m2
for intermediate or high-risk groups. The target 24-hours (24h) MTX
concentrations were set at 33 μmol/L for LR and 65 μmol/L for non LR
group. Results: The median 24h MTX concentrations were 42.0 μmol/L for
LR and 70.0 μmol/L for non LR group. Only SLCO1B1 genotype in the LR
group and age in the non LR group was associated with the 24h MTX
concentrations. The survival results were comparable between patients
with or without courses failed to reach the target 24h MTX
concentration. MTX excretion delay was observed in 211/1435 (14.7%)
courses of 125 patients, which more commonly caused MTX-induced
toxicities. All the 6 CNS relapses occurred in patients with MTX
excretion delay, while in those without did not have any type of CNS
relapse (6/119 vs. 0/121, P=0.015). Patients with more than 20% of MTX
excretion delay courses had significant worse survival (83.8%±5.0% vs.
93.7%±1.8% for EFS, P=0.014, and 88.8%±4.3% vs. 97.2%±1.1% for OS,
P=0.010). Conclusions: Achieving the target 24h MTX concentration during
HD-MTX therapy is not the useful indicator to predict the survival of
ALL patients. MTX excretion delay is an independent factor for
predicting the CNS relapses and worse prognosis.
A case study of a patient with CMT4F based on ICF-CY framework
Authors: Zhang Jing , Yuan Longyuan , Li Zhihui , Lv Wei , He Jing
Published: March 2022

This case is the first time to combine ICF-CY conceptual framework with
GMFM-88 item functional scale and use it in the rehabilitation and
diagnosis of early childhood onset patients with CMT4F.Through
periodical training, the effectiveness to guide rehabilitation diagnosis
and treatment for early onset CMT4F patients was proved.
Effect of Rehmannia glutinosa and Cornus officinalis herb couple on CKD rats via modulating the intestinal microbiota and enhancing intestinal barrier
Authors: wang ling , zhu jin hui , jiang xiao dan , ma zhenxiang , Tao Jin Hua
Published: March 2022

Background and Purpose: CKD is a clinical syndrome with slow development
and gradual deterioration of renal function. At present, modern medicine
still lacks an ideal treatment method for this disease, while TCM has
accumulated rich clinical experience in the treatment of CKD, which can
effectively improve renal function and delay renal failure, and has
unique advantages. RC is widely used in clinical practice to treat CKD,
especially the ‘Kidney-Yin’ deficiency syndrome. However, the
compatibility mechanisms responsible for its effects in experimental
studies, including preclinical and clinical researches, are still not
fully understood. Experimental Approach: Adenine-induced CKD rats were
used to investigated the preventive effect of RC on CKD rats. According
to the Illumina-based high-throughput 16S rRNA gene sequencing results,
to discuss the flora abundance of rats in different treatment group.
Using Chamber, Western blot and PCR were used to investigate the effects
of RC on intestinal barrier function and its molecular mechanism in
model animals. H&E and M&T staining diagram were used to observe the
pathological state of renal tissue in different group. ELISA was used to
study the expression of inflammatory factors in different treatment
group. Conclusion and Implications: We obtained evidence showing an
obvious effect of RC on strengthening the intestinal barrier and
modulating gut microbiota in adenine-induced CKD rats. This project
revealed the compatibility mechanism of RC in regulating intestinal
microecology and barrier function to intervene in CKD, and provided
basis and ideas for the clinical application of RC and the development
of innovative drugs for CKD.
The effects of deliberation on citizen knowledge, attitudes and preferences: A case study of a Belgrade deliberative mini public
Authors: Djordjevic Ana , Vasiljevic Jelena
Published: March 2022

Participation in deliberative arenas is often lauded for its transformative impact on citizens? attitudes, sense of agency and ability to formulate concrete policy proposals. The focus of this paper is the first ever deliberative mini public in Belgrade, centred on the topic of expanding the pedestrian zone and rerouting traffic in the city core. By relying on a set of qualitative and quantitative data collected before and after the deliberation, we aim to explore the effects of the public deliberation on the participants? knowledge, attitudes and preferences. Our hypothesis was that participation in this deliberative process led to better understanding (enhanced knowledge) of the discussed topic and change in attitudes and preferences regarding its realization. The scope of this study is limited, given the non-experimental design and small sample. Overall, the results indicate that participants` knowledge on the topic of deliberation is enhanced, becoming more precise, elaborate and encompassing different perspectives. As for the attitudes and preferences, in most cases, around two-thirds of the sample changed their positions, while about a third of the sample changed sides, mostly agreeing less with the expansion of the pedestrian zone. The findings support the conclusion that, on a local level, deliberation has the capacity to inform and enhance competence for greater political participation.
The finishing and cleaning of long parts in screw rotors
Authors: Lebedev V. A. , Al-Obaidi L. M. R. , Koval N. S.
Published: March 2022

Introduction. To search for effective methods of finishing and stripping of long-length parts, it is advisable to create a rotary-screw process system of a pass-through type. Its main working element is a screw rotor, which is a combination of flat elements of various shapes and sizes, multidirectional with respect to the helical lines around the perimeter. The purpose of this study is to justify the intensity of the machining process in devices equipped with a screw rotor.

Materials and Methods. Metal removal is accepted as the main parameter determining the intensity of the machining process in screw rotors. Within the framework of the presented study, processing was performed on an experimental rotary-screw installation. The processing medium consisted of molded abrasive pellets of the PT 10x10 brand. The research conditions were as follows: loading volume (without part) — 60 %; rotor speed — 50 rpm; processing time – 30, 60, 90 min; rotor axis tilt angles — 0о and 5о. The influence of treatment modes and conditions on the process intensity was considered on plate samples with dimensions of 80×10×1 mm made of aluminum alloy D16T. To determine metal removal, the samples were weighed on Ohaus AX223 analytical balance before and after processing.

Results. The patterns of metal removal from samples at different processing times, the location of samples in the working area of a screw rotor with different angles of inclination, and its speed are presented.

Discussion and Conclusions. The regularities established in the course of research indicate the efficiency of rotaryscrew process systems for solving problems on the finishing treatment of long-length parts. The main factors that control such processing in devices with a screw rotor and affect its intensity (and, as a consequence, the process performance) are the screw rotor speed, the shape of the perimeter, and the axis angle.
Kajian Analisis Model Pembelajaran Problem Based Learning Terhadap Peningkatan Kemampuan Komunikasi Matematis Siswa
Authors: Panjaitan M. Azhari , Panjaitan Asmin
Published: March 2022

Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan komunikasi matematis siswa yang diajar dengan model pembelajaran problem based learning, Untuk mengetahui pengaruh model pembelajaran problem based learning terhadap kemampuan komunikasi matematis siswa, Untuk mengetahui kelebihan dan kekurangan dari model pembelajaran problem based learning berdasarkan hasil temuan penelitian. Metode yang digunakan dalam penelitian ini adalah studi literatur (penelitian kepustakaan). Data yang dikumpulkan merupakan data sekunder berupa hasil penelitian dari jurnal ilmiah, buku, dan skripsi atau tesis. Selanjutnya, data tersebut dianalisis dengan teknik “analisis anotasi bibliografis”. Hasil penelitian menunjukkan bahwa (1) Penerapan model pembelajaran problem based learning yang diajarkan kepada siswa pada saat pembelajaran matematika dapat meningkatkan kemampuan komunikasi matematis siswa. (2) Terdapat Pengaruh dari model pembelajaran problem based learning terhadap kemampuan komunikasi matematis siswa. (3) Beberapa kelebihan dan kekurangan model pembelajaran problem based learning berdasarkan temuan penelitian,  yaitu dari sisi kelebihannya bahwa kemampuan komunikasi matematis siswa meningkat setelah pembelajaran dengan model problem based learning, siswa menjadi lebih aktif dalam pembelajaran, menjadikan siswa mampu mengerjakan soal yang berbeda dari contoh yang diberikan, siswa mampu mencari dengan sendiri, mengalami interaksi antar kelompok dan saling tukar pemikiran secara ilmiah, dan mampu menyelesaikan proses pemecahan masalah. Akan tetapi ada terdapat nilai negatif atau kekurangan dibalik pelaksanaan model pembelajaran berbasis masalah atau kendala yang dialami berupa persiapan pelaksanaan, kurangnya memahami apresiasi guru, jumlah kelompok terlalu banyak, dan keterbatasan waktu dalam pembelajaran
Determinants of Debt Maturity Structure: Evidence from Indonesian Companies
Authors: Elsa Theresia , Butar Sansaloni Butar
Published: March 2022

AbstractThis study examines the effect of earnings management, firm size, asset maturity, and leverage on the debt maturity structure. The debt maturity structure refers to the proportion of long-term debt to total debt. The choice between long-term and short-term debt has its own consequences. Long-term debt bears higher debt costs but the payback period is long enough to make it easier for companies to pay debt installments. Samples were taken from public companies listed on the Indonesia Stock Exchange (IDX) in 2016-2020 that met the sample criteria. The final observations that meet the sample criteria during the research period are 2,229 company years. Hypotheses were tested using multiple linear regression and the results showed that earnings management had a negative effect on the debt maturity structure. These results indicate that the company prefers short-term debt rather than long-term debt. In addition, firm size and asset maturity have a positive effect on the structure of debt maturity and leverage has no effect on the structure of debt maturity.AbstrakPenelitian ini menguji pengaruh manajemen laba, ukuran perusahaan, maturitas aset, dan leverage terhadap struktur maturitas utang. Struktur jatuh tempo utang mengacu pada proporsi utang jangka panjang terhadap total utang. Pilihan antara utang jangka panjang dan jangka pendek memiliki konsekuensi tersendiri. Utang jangka panjang menanggung biaya utang yang lebih tinggi namun payback periodnya cukup lama sehingga memudahkan perusahaan dalam membayar cicilan utang. Sampel diambil dari perusahaan publik yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2016-2020 yang memenuhi kriteria sampel. Observasi akhir yang memenuhi kriteria sampel selama periode penelitian adalah 2.229 tahun perusahaan. Pengujian hipotesis menggunakan regresi linier berganda dan hasilnya menunjukkan bahwa manajemen laba berpengaruh negatif terhadap struktur jatuh tempo utang. Hasil ini menunjukkan bahwa perusahaan lebih menyukai utang jangka pendek daripada utang jangka panjang. Selain itu, ukuran perusahaan dan jatuh tempo aset berpengaruh positif terhadap struktur jatuh tempo utang dan leverage tidak berpengaruh terhadap struktur jatuh tempo utang.
Realization of Economic Justice Through Teleworking.
Authors: Safdari Mehdi , Bafrani Alireza Arab , Ghomi Afsaneh Bagheri
Published: March 2022

The economy of any country is unique to its own ideology, studying economic conditions and management/work arrangement are not separated. Methodology: Hence, in devising a model, it is necessary to respect work style changes that impact on work distribution among potential people. Automating the works and performance whole or partly by teleworking can have an impact on increasing digital economic power. likewise, teleworking can be along with removing time and place barriers, using rural workforce, women with small children, disabled persons, part time forces and so on which would employ higher forces and would reduce the unemployment rate. Results: Despite its costs, in the case, that teleworking is executed properly; it would cause a big economic revolution due to its resilience and compensating its costs. In the present study, the impact of teleworking on economic justice will be discussed.  Conclusion: It can be said that teleworking increase competitive potency and reduce the unemployment rate as, as a result, would establish economic justice.
The analysis of personality features, coping strategies and stress relations in drug addicts
Authors: Jenaabadi Hossein , Issazadegan Ali
Published: March 2022

The purpose of this study is the analysis of the relation between personality features with coping strategies against mental disorders and stress in drug addicts in Kahnuj city. Methodology: Personality features include five factors: extroversion, mental disorders, solution, agreement, and consciousness. The coping strategy mentioned in this study is dealing with the excitement and it is avoidable. The questionnaire was given to 120 drug addicts who voluntarily looked up to the clinic. In order to collect the data 2 types of the questionnaire were used: Neo questionnaire, and Endler & Parker questionnaire. The collected data was analyzed according to descriptive, correlation and Regression procedures. Results: Conclusion illustrated that drug addicts use the coping strategy of excitement more and instead of dealing with the problem that the purpose is to eradicate the problem, they use a coping strategy of excitement. In this coping strategy, the person tries to control the excitement results, does not consider solving the problem, and does not use matter strategies a lot. Conclusion: Regarding the aspect of mental disorders, drug addicts have high scores and due to wrong evaluation, these persons are usually disturbed, worried, depressed and affected by feelings and excitements. They act according to important people's expectation or decision and affected by their environmental condition.
Poverty and the Measurements
Authors: Yadollahi Mehdi , Jafari Maryam Arabzadeh , Roohbakhsh Najmeh , Bakhtiary Mojtaba
Published: March 2022

Poverty is a condition in which a person or community lacks the fundamentals for having a minimum standard of well-being and life. Methodology: These fundamentals may be material resources such as food, safe drinking water, and shelter or they may include social resources like access to information, education, health care, social status, and political power, or the opportunity to develop meaningful connections with other people in society. Results: Poverty amid plenty is the world's greatest challenge and eradicating poverty is an ethical, social, political and economic imperative of humankind. To eliminate or reduce poverty it should be measured. The aim of measuring poverty is usually to make economic status comparisons between two or more groups. Conclusion: The present research examined the measures of poverty and then consequences and different aspects of poverty were regarded. Finally, poverty reduction and critiques of the poverty measure were described.
Comparative study of cultural and social factors affecting urban and rural women's Burnout in Shahrekord Township
Authors: Shirvani Mina , Mohammadi Asghar , Shirvani Faramarz
Published: March 2022

This study, entitled "a comparative study of cultural and social factors affecting urban and rural women's Burnout in Shahrekord Township in the form of a case study is done. Methodology This method was a kind of causal-comparative is. The study of the Statistical Society of all working women in rural and urban areas of the city in the year 2013 has been established based on the information available total urban and rural employed 28712 is n. Results: The sample size of the study was determined against the person with 379 samples using a quota method combination;-cluster, were selected. For hypothesis testing research of using MANOVA test and SPSS software version, 19 is used to. Conclusion: The research results showed that the level of education and urban and rural women's satisfaction on the job Burnout and influencing them in between the urban and rural women is almost equal, and no significant difference in effect on Burnout but other variables with significant differences between urban and rural women employed Burnout they overshadowed him.
Study of Effective Factors on Job Satisfaction of Omid Hospital Staff in Isfahan City
Authors: Haghshenas Soheila , Iravani Mohammadreza , Nasrabadi Hasanali Bakhtiar
Published: March 2022

This study investigated factors affecting the job satisfaction of Omid hospital staff is performed. This research is correlational and cross-sectional study was conducted in 2013 the sample population included all Omid hospital staff. It is also stratified random sampling; 183 people were selected according to Cochran's sampling formula. Methodology: Data also were collected using a standard questionnaire with good validity and reliability, and then to analyze the statistical methods included analysis of variance (ANOVA), T-test and Pearson's correlation coefficient was used. According to these findings, with an average satisfaction rate of pay received (M=9.40) has the lowest levels of satisfaction among employee job satisfaction. Satisfaction with job promotion with a mean (M=10.17) is the next category. On the other hand, with the average job satisfaction (M=22.52) the highest levels of satisfaction among job satisfaction, dedicated to the satisfaction with the supervisor, with a mean (M=21.56) is the next category. Results: These data indicate that job satisfaction and supervisor satisfaction among employees better salary of satisfaction, and satisfaction with the job promotion. Conclusion: In the bivariate analysis also showed that there is a significant difference between job satisfaction and gender, the inverse relationship between job satisfaction and lower-income workers and there, While the relationship between age and job satisfaction, and the other between education level and work experience personnel, and there is no significant relationship between job satisfaction and so on, depending on the type of employment between job satisfaction, and there is no significant difference in terms of marital status.
Benchmarking in the healthcare system
Authors: Slinin A. S. , Kostin F. N.
Published: March 2022

The article presents a generalized analysis of information on benchmarking in the healthcare system of both the Russian Federation and foreign countries. The possibilities of benchmarking in the analysis, comparative evaluation of the methods used in the implementation of the functions of medical organizations are shown.
The diagnostic value of presepsin as a marker for congenital infections in newborns
Authors: Sharafutdinova D. R. , Balashova E. N. , Sukhova Yu. V. , Kessler Yu. V. , Kirtbaya A. R. , Ryndin A. Yu. , Golubtsova Yu. M. , Shakin I. A. , Solomonova A. V. , Artamkina E. I. , Ivanets T. Yu. , Ionov O. V. , Zubkov V. V.
Published: March 2022

The identification of the earliest diagnostic markers for infections in newborns remains one of the priorities in neonatology. In our study, we aimed to assess the diagnostic value of presepsin (P-SEP) as a marker for congenital infections in newborn children. The study was prospective in design and took place from January 2020 to February 2021. We enrolled a total of 64 children with a gestational age of 24 to 40 weeks. The study was approved by the Biomedical Research Ethics Committee (Minutes No.12 of 17 November 2016) and the Scientific Council (Minutes No.19 of 29 November 2016) of the V.I. Kulakov NMRC OGP of Ministry of Healthcare of the Russian Federation. Written voluntary consent to the patients’ participation in the study was obtained from their legal representatives. The patients were divided into 2 groups: a group of interest consisting of newborn children with congenital infections (n = 30), and a control group comprising newborns without signs of infection (n = 34). The group of interest included children with congenital pneumonia (n = 25), urinary tract infections (n = 3), and infections specific to the perinatal period, without a focus of infection (n = 2). Gestational age and birth weight were comparable between the groups. No statistically significant differences in CRP levels, neutrophil counts, immature-to-total neutrophil ratios and lactate concentrations on days 1 and 3 of life were found between the two groups. In the group of interest, P-SEP on day 1 of life was significantly higher than in the control group (р = 0.015). Our findings suggested that P-SEP levels ≥ 481 pg/mL could predict a high risk of congenital infections in newborns. The sensitivity and specificity were 91.0% and 60.0% respectively. P-SEP levels determined in capillary blood were similar to those obtained from venous blood samples suggesting that either can be used for P-SEP measurement with equal success. P-SEP levels were shown to decrease by day 3 of life in the children with congenital infections who had been treated with antibiotics.
The best use of technology in the health emergency operation centers during COVID-19 pandemic
Authors: Dinar Hisham , Alqarni Abdullah , Ali Mohammad , Abualenain Jameel
Published: March 2022

Since the outbreak of the coronavirus in the Kingdom of Saudi Arabia in 2020, National Health Emergency Center aligned itself to the Saudi Arabia's Vision 2030 and has played a key role to link the different health sectors in the country with Ministry of Health, through the use of state-of-the-art infrastructure, innovative digital technologies, location intelligence, data analysis, and real time data. Thereby, General Directorate of Emergency, Disasters and Medical Transportation - Deputyship of Curative Services, launched the National Health Emergency Operation Center, which integrates digital technologies to deliver substantial improvements to emergency healthcare management. Through real-time maps, apps, and dashboards, the innovative integration of different technologies has revolutionized the Center's operations by providing location intelligence and evidence-based analysis that shapes sound policy and saves lives. Disaster health management has become a key goal for every nation in order to reduce the impact of disasters on human health and wellbeing. It is an important aspect of any resilient healthcare system.
Implementation of a Targeted Inhaled Corticosteroid De-Escalation Process in Patients with Chronic Obstructive Pulmonary Disease in the Primary Care Setting
Authors: Hahn Nicole M. , Nagy Michael W.
Published: March 2022

Purpose: To evaluate the feasibility and success of a pharmacist-led, targeted inhaled corticosteroid (ICS) de-escalation process in patients with chronic obstructive pulmonary disease (COPD) where the risks of ICS therapy outweigh the potential benefits.
Methods: A population health data management tool was leveraged to identify patients who may qualify for ICS de-escalation. Primary care pharmacists clinically reviewed and subsequently contacted patients who were determined to be appropriate candidates. After discussion on the risks and benefits of ICS therapy, a stepwise algorithm was utilized to assist with ICS de-escalation and optimization of bronchodilator therapy. Outcomes analyzed include the proportion of patients for whom ICS was de-escalated, patient acceptability of the intervention, time taken to complete the intervention, barriers to implementation, and the number of additional interventions made by pharmacists.
Results: Of the 126 patients originally identified as potential candidates, 58 (46.0%) were deemed appropriate to proceed with ICS de-escalation and successfully contacted by a pharmacist. Of these patients, 49 (84.5%) were agreeable and ultimately 42 were successfully de-escalated with 37 patients maintained off ICS. The average time required for an encounter was 15.8 minutes.
Conclusion: There is utility in a pharmacist-driven, targeted ICS de-escalation process to facilitate meeting guideline-directed medication therapy goals in patients with COPD, granted the availability of efficient tools to assist in identifying patients that qualify. Such a targeted approach increases pharmacist involvement in medication management of COPD and can expand the primary care pharmacy practice.