bluuebunny/crossref_metadata_2025 huggingface dataset:
Green Synthesis of Fe3O4 Nanoparticles and Its Applications in Wastewater Treatment
Authors: Bassim Shahnaz , Mageed Alyaa K. , AbdulRazak Adnan A. , Majdi Hasan Sh.
Published: December 2022

In this paper, the extract of Citrus aurantium (CA) was used as a green approach for the preparation of Fe3O4 nanoparticles. The green Fe3O4 (Fe3O4/CA) was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy analysis (EDX), Fourier-transform infrared (FTIR) spectroscopy, Brunauer–Emmett–Teller (BET) surface area measurement, and vibrating sample magnetometry (VSM). The synthesized Fe3O4/CA was used to remove methylene blue (MB) dye from an aqueous solution. A four-factor central composite design (CCD), combined with response surface modeling (RSM), was used to maximize the MB dye removal. The four independent variables, which were initial dye concentration (10–50 mg/L), solution pH (3–9), adsorbent dose (ranging from 200–1000 mg/L), and contact time (30–90 min), were used as inputs to the model of the perecentage dye removal. The results yielded by an analysis of variance (ANOVA) confirmed the high significance of the regression model. The predicted values of the MB dye removal were in agreement with the corresponding experimental values. Optimized conditions for the maximum MB dye removal (93.14%) by Fe3O4/CA were the initial dye concentration (10.02 mg/L), pH (8.98), adsorbent mass (997.99 mg/L), and contact time (43.71 min). The validity of the quadratic model was examined, and good agreement was found between the experimental and predicted values. Our findings demonstrated that green Fe3O4NPs is a good adsorbent for MB removal.
A Binary Mixture of Emamectin Benzoate and Chlorantraniliprole Supplemented with an Adjuvant Effectively Controls Spodoptera frugiperda
Authors: Zhang Junteng , Jiang Jianjun , Wang Kan , Zhang Yixi , Liu Zewen , Yu Na
Published: December 2022

The fall armyworm (FAW) Spodoptera frugiperda is a notorious pest, causing severe crop damage worldwide and prompting effective prevention and control. Over-reliance on and intensive use of insecticides are prone to leading to the rapid evolution of insecticide resistance, urging rational insecticide application. One effective way of rational insecticide application is to apply insecticides of different modes of action in combination or supplemented with adjuvants. In this study, we assessed the efficacies of two individual insecticides, emamectin benzoate (EB) and chlorantraniliprole (CT), and their mixture, supplemented with and without the oil adjuvant Jijian® to control FAW in laboratory bioassays and a field trial. Both EB and CT showed high toxicities to FAW. The EB × CT mixture at a mass ratio of 9:1 yielded a remarkable synergistic effect, with the co-toxicity coefficient (CTC) being 239.38 and the median lethal concentration (LC50) being 0.177 mg/L. In leaf-spray bioassays, the addition of the adjuvant reduced the LC50 values of both the individual insecticides and the EB × CT mixture by more than 59%, significantly improving the efficacies. The field trial confirmed the synergistic effects of the adjuvant, which reduced the amount of EB × CT mixture by 80%. This study provides an effective and promising insecticide–adjuvant mixture to control S. frugiperda.
On the Origin of Neo-Sex Chromosomes in the Neotropical Dragonflies Rhionaeschna bonariensis and R. planaltica (Aeshnidae, Odonata)
Authors: Mola Liliana M. , Vrbová Iva , Tosto Daniela S. , Zrzavá Magda , Marec František
Published: December 2022

Odonata have holokinetic chromosomes. About 95% of species have an XX/X0 sex chromosome system, with heterogametic males. There are species with neo-XX/neo-XY sex chromosomes resulting from an X chromosome/autosome fusion. The genus Rhionaeschna includes 42 species found in the Americas. We analyzed the distribution of the nucleolar organizer region (NOR) using FISH with rDNA probes in Rhionaeschna bonariensis (n = 12 + neo-XY), R. planaltica (n = 7 + neo-XY), and Aeshna cyanea (n = 13 + X0). In R. bonariensis and A. cyanea, the NOR is located on a large pair of autosomes, which have a secondary constriction in the latter species. In R. planaltica, the NOR is located on the ancestral part of the neo-X chromosome. Meiotic analysis and FISH results in R. planaltica led to the conclusion that the neo-XY system arose by insertion of the ancestral X chromosome into an autosome. Genomic in situ hybridization, performed for the first time in Odonata, highlighted the entire neo-Y chromosome in meiosis of R. bonariensis, suggesting that it consists mainly of repetitive DNA. This feature and the terminal chiasma localization suggest an ancient origin of the neo-XY system. Our study provides new information on the origin and evolution of neo-sex chromosomes in Odonata, including new types of chromosomal rearrangements, NOR transposition, and heterochromatin accumulation.
Atherosclerotic Cardiovascular Disease: Risk Assessment, Prevention and Treatment Strategies
Authors: Jeras Jernej , Ugovšek Sabina , Rehberger Likozar Andreja , Šebeštjen Miran
Published: December 2022

Despite enormous advances in both surgical and pharmacological treatment, cardiovascular diseases are still the most common cause of morbidity and disability in the western world [...]
Excessive Supraventricular Ectopic Activity and the Risk of Atrial Fibrillation and Stroke: A Systematic Review and Meta-Analysis
Authors: Yang Min , Lin Yapeng , Cheng Hang , Zheng Danni , Tan Song , Zhu Liping , Li Zimeng , Wang Xiaoyun , Yang Jie
Published: December 2022

Background: Excessive supraventricular ectopic activity (ESVEA) is correlated with the development of atrial fibrillation (AF) and is frequently observed in ischemic stroke patients. This meta-analysis aims to summarize the evidence on the association between ESVEA and the risk of AF and stroke. Methods: PubMed and Embase databases were systematically searched to identify all publications providing relevant data from inception to 23 August 2022. Hazard ratio (HR) and 95% confidence interval (CI) were pooled using fixed-effect or random-effect models. Results: We included 23,272 participants from 20 studies. Pooled results showed that ESVEA was associated with an increased risk of AF in the general population (HR: 2.57; 95% CI 2.16–3.05), increased risk of AF in ischemic stroke patients (HR: 2.91; 95% CI 1.80–4.69), new-onset ischemic stroke (HR: 1.91; 95% CI 1.30–2.79), and all-cause mortality (HR: 1.41; 95% CI 1.24–1.59). Pooled analysis indicated that ESVEA was not associated with recurrent ischemic stroke/transient ischemic attack (TIA) (HR: 1.24; 95% CI 0.91–1.67). Conclusions: ESVEA is associated with AF, new-onset ischemic stroke, and all-cause mortality.
Humeral and Glenoid Version in Reverse Total Shoulder Arthroplasty: A Systematic Review
Authors: Berton Alessandra , Longo Umile Giuseppe , Gulotta Lawrence V. , De Salvatore Sergio , Piergentili Ilaria , Calabrese Giovanni , Roberti Federica , Warren Russell F. , Denaro Vincenzo
Published: December 2022

There is increasing interest in reverse total shoulder arthroplasty (RTSA) as a reliable treatment for arthritic, rotator cuff deficient shoulders. Humeral and glenoid version are controversial parameters that can influence internal and external rotation, muscular forces, and implant stability as outcomes of RTSA. The aim of this study was to obtain an overview of the current knowledge on the effect of both humeral component version and glenoid component version and give recommendations on their most optimal degree for RTSA. A comprehensive quantitative review of the published literature on the effect of humeral version and glenoid version in RTSA was performed, to identify its influence on the range of movement, muscle forces, and intrinsic stability of the reverse prosthesis. Eleven studies were included: nine were biomechanical studies, one was a clinical-radiographic study, and one was an implant design consideration. Anterior stability can be improved by implanting the humeral component in neutral or with some anteversion. Glenoid component retroversion has been proven to reduce the likelihood of subluxation, while increasing ER and ROM at the same time. The study was conducted considering 5° anteversion; neutral; and 5°, 10°, and 20° retroversion of the glenoid component. Although a final opinion has not been yet expressed on the matter, the general consensus tends to agree on restoring 0° to 20° of retroversion of the humeral and glenoid component to yield the best outcomes.
Oral Anticoagulant Use and Appropriateness in Elderly Patients with Atrial Fibrillation in Complex Clinical Conditions: ACONVENIENCE Study
Authors: Bonanad Clara , Formiga Francesc , Anguita Manuel , Petidier Roberto , Gullón Alejandra
Published: December 2022

Non-valvular atrial fibrillation (NVAF) is the most common arrhythmia in older patients. Although direct-acting oral anticoagulants (DOAC) are the antithrombotic treatment of choice, irrespective of age, certain factors may limit their use. The aim of the ACONVENIENCE study was to consult the opinion of a multidisciplinary panel of experts on the appropriateness of using OACs in elderly patients (>75 years) with NVAF associated with certain complex clinical conditions. A consensus project was performed on the basis of a systematic review of the literature, and application of a two-round Delphi survey. The agreement of 79 panellists on 30 Delphi-type statements was evaluated, and their opinion on the appropriateness of different oral anticoagulants in 16 complex clinical scenarios was assessed. A total of 27 consensus statements were agreed upon, including all statements addressing anticoagulation in older patients and in patients at high risk of bleeding complications, and most of those addressing frailty, dementia, risk of falling, and complex cardiac situations. It was almost unanimously agreed upon that advanced age should not influence the anticoagulation decision. Apixaban was the highest-rated therapeutic option in 14/16 situations, followed by edoxaban. There is a high degree of agreement on anticoagulation in older patients with NVAF. Age should not be the single limiting factor when prescribing OACs, and the decision should be made based on net clinical benefit and a comprehensive geriatric assessment. Apixaban, followed by edoxaban, was considered the most appropriate treatment in the various complex clinical situations examined.
Effects of Two-Phase Treatment with Functional Appliances Followed by Extraction versus One-Phase Treatment with Extraction in Class II Growing Patients: A Case–Control Study
Authors: Wong Ka Fai , Chen Wener , Ren Jianhan , Yang Yanqi , Lin Yifan
Published: December 2022

Objectives: Fixed appliance treatment with premolar extraction is often required after functional appliance treatment to relieve crowding and improve facial aesthetics in the Asian population. This study compared the treatment efficacy of two approaches for treating Class II division 1 malocclusion: functional appliance followed by fixed appliance treatment with extraction (two-phase) and fixed appliance treatment with extraction (one-phase). Methods: Growing skeletal Class II patients with an overjet of ≥6 mm treated with two- or one-phase orthodontics were included. The two groups consisted of 29 patients (mean age = 12.55) and 30 patients (mean age = 12.72), respectively. Pre- and post-treatment cephalograms were analysed and skeletal, dental, and soft tissue characteristics were compared using independent t-tests. Treatment changes were compared within and between groups using paired and independent t-tests, respectively. Stepwise discriminant analysis was performed to identify the variables that best predicted pre-treatment group allocations. Results: At baseline, there were no significant between-group differences in age, gender, cervical vertebral maturation, or overjet. The two-phase group had greater Class II skeletal discrepancies (ANB angle and Wits appraisal). During treatment, the two-phase group showed greater improvements in intermaxillary relationship and facial convexity compared with the one-phase group (p < 0.01). Following treatment, the two-phase group had a greater L1/APog distance (p < 0.05). Facial convexity and Wits appraisal were identified as parameters significantly influencing the clinicians’ decision to use a one- or two-phase approach. Conclusions: In patients requiring premolar extraction, two-phase (vs. one-phase) treatment produced greater improvements in the intermaxillary relationship and facial convexity.
Effect of Supervised over Self-Performed Eccentric Exercise on Lateral Elbow Tendinopathy: A Pilot Study
Authors: Oya-Casero Antonio , Muñoz-Cruzado Barba Miguel , Madera-García Manuel , García-LLorent Rosario , Andrade-Ortega Juan Alfonso , Cuesta-Vargas Antonio I. , Roldán-Jiménez Cristina
Published: December 2022

Background: The efficacy of eccentric exercise self-performed by the patient has not been proved in the treatment of lateral elbow tendinopathy (LET). The aim of this study was to compare the effects of a programme of eccentric exercises applied by a physiotherapist to patients with LET through a structured manual programme compared to its self-performance, guided by an illustrated brochure. Method: A single-blind, pilot, randomised, controlled trial was conducted. Twenty patients were randomised. The intervention group carried out eccentric exercises applied directly by a physiotherapist (10 sessions). The control group carried out eccentric exercises that were self-performed by the patient (10 sessions). Both groups received simulated ultrasounds. Pain (visual analogue scale (VAS)), function (DASH questionnaire) and satisfaction (with a Likert scale) were measured at the beginning of the intervention, immediately after the intervention and 3 months after the intervention. Results: The mean age was 53.17 and 54.25 years old. The experimental group presented a greater tendency to improve function (DASH −15.91) and reduce pain (VAS −2.88) compared to the control group, although these differences were not significant (p > 0.05). Conclusion: Eccentric exercise, both performed by the physiotherapist and self-performed by the patient, improved function and pain in the patients with LET.
New Seismoacoustic Data on Shallow Gas in Holocene Marine Shelf Sediments, Offshore from the Cilento Promontory (Southern Tyrrhenian Sea, Italy)
Authors: Aiello Gemma , Caccavale Mauro
Published: December 2022

High-resolution seismoacoustic data represent a useful tool for the investigations of gas-charged sediments occurring beneath the seabed through the identification of the diagnostic intrasedimentary features associated with them. Acoustic blanking revealed shallow gas pockets in the seismostratigraphic units of the inner shelf off the Northern Cilento promontory. Six main seismostratigraphic units were recognized based on the geological interpretation of the seismic profiles. Large shallow gas pockets, reaching a lateral extension of 1 km, are concentrated at the depocenter of Late Pleistocene–Holocene marine sediments that are limited northwards by the Solofrone River mouth and southwards by the Licosa Cape promontory. A morphobathymetric interpretation, reported in a GIS environment, was constructed in order to show the main morphological lineaments and to link them with the acoustic anomalies interpreted through the Sub-bottom chirp profiles. A newly constructed workflow was assessed to perform data elaboration with Seismic Unix software by comparing and improving the seismic data of the previously processed profiles that used Seisprho software. The identification of these anomalies and the corresponding units from the offshore Cilento promontory represent a useful basis for an assessment of marine geohazards and could help to plan for the mitigation of geohazards in the Cilento region.
An Assessment of Catches of Shore and Boat Recreational Angling along the Coast of the Adriatic Sea
Authors: Soldo Alen
Published: December 2022

Recreational fisheries involve millions of people globally, thus there is a growing recognition of the immense economic, sociocultural and ecological importance of recreational fishing as a significant component of global capture fisheries. However, recreational fishing is still not as controlled nor as well investigated as commercial fishing. Although the difference between commercial and recreational fisheries may be obvious, the definition of recreational fishing is not uniform, and the issue becomes more difficult in the case of sport fishing. The clear distinction between sport and recreational fisheries is vague, in particular due to a lack of definition of what constitutes a “recreational” or “sport” fishery. In this study, sport fisheries is considered as the competition-oriented subcategory of recreational fisheries, involving a subset of recreational fishers that participate in fishing competitions. Obtained results from the Adriatic Sea showed differences between shore and boat angling in terms of the species caught and the CPUE, while a comparison of the results from competition and out-of-competition boat angling revealed different tactics and targets of the recreational fishers, which are more efficient than sport fishers. Thus, there is an urgent need for all-inclusive management in the Mediterranean region, particularly because of the social and economic conflicts that may arise and intensify with the decline of the accessible fish resources.
Stability and Growth Pact: Too Young to Die, Too Old to Rock ‘n’ Roll
Authors: Patsoulis Patroklos , Psychalis Marios , Deirmentzoglou Georgios A.
Published: December 2022

This paper discusses the future of the Stability and Growth Pact (hereafter SGP). Although Neoclassical economic models argue that strict fiscal and monetary rules minimize moral hazard and crowding out, in practice many governments adopt fiscal expansion (in recent years in the form of non-standard monetary measures) to mitigate market failures, consequently rethinking monetary rules and targets. Government spending and countercyclical policies are essential tools for soothing business cycles and other market failures. To this end, we empirically test whether current and past forms of the SGP have led to greater convergence, while we critically assess and investigate a possible SGP reform. By adopting more flexible rules, in terms of government spending and fiscal expansion, the Economic and Monetary Union (hereafter EMU) could yield multiple positive spillover effects in long-term economic growth under specific terms and conditions, such as green conditionalities. We conclude that to mitigate the triple crisis threat (economic, environmental and health), what is mostly needed are reforms in the form of fiscal federalism, such as common debt issuance (Eurobonds) that enhance the ability of the EMU to tackle the consequences of the aforementioned crises.
Post-2008 Fiscal Stimulus Packages and the Driving Forces for China’s Urbanization
Authors: Wong David W. H. , Lee Harry F. , Zhao Simon X. B. , Tai Andy C. L.
Published: December 2022

A growing body of research has sought to determine how different factors have affected urbanization in developed countries over the past decades. Yet, few studies have systematically examined urbanization’s driving forces, particularly in emerging economies. In 2008–2009, the Chinese government announced an economic stimulus program to revitalize an economy struck by the 2007–2008 Global Financial Crisis. This study aims to identify how urbanization’s driving forces evolved under a drastic change in fiscal policy and revisit the conventional urbanization theories in the Chinese context. Using a dataset covering 31 Chinese provinces and spanning the periods 2005–2011 and 2013–2015, we employ panel data regressions to analyze whether such a fiscal arrangement affected urbanization in China. Throughout the entire period, the fiscal stimulus program caused a change in the drivers for urbanization at the national and regional levels. Before the implementation of the program, industrialization drove urbanization. After the program’s implementation, land financialization was crucial in promoting urbanization across the country. Our findings challenge the conventional urbanization theory—industrialization is always the primary driving force of urbanization in emerging economies. Land financialization, a kind of tertiary production, can also drive urbanization significantly.
Effect of Photodynamic Therapy with Chlorin e6 on Canine Tumors
Authors: Shrestha Rajeev , Lee Hyun Ji , Lim Junmo , Gurung Pallavi , Thapa Magar Til Bahadur , Kim Young-Tak , Lee Kija , Bae Seulgi , Kim Yong-Wan
Published: December 2022

This work aims to prepare pure Chlorin e6 (Ce6) and establish Ce6-mediated photodynamic therapy (Ce6-PDT) as a better therapy option for canine tumors as well as mouse tumor models. Five dogs suffering from various cancers were treated with Ce6-PDT from one to several times. After receiving the Ce6 (2.5 mg/kg) for 3 h, tumors were illuminated superficially or interstitially with 660 nm light. Two dogs underwent Ce6-guided fluorescence imaging by photodynamic diagnosis (PDD). Cell proliferation and apoptosis were detected by the 4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot assay, respectively. Ce6-PDT efficacy was also determined using melanoma and pancreatic cancer mouse models. Two veterinary patients with mammary carcinoma and histiocytic sarcoma had their tumors significantly diminished and showed improved health after receiving Ce6-PDT. Moreover, in the cases of canine tumors, the adjunctive use of Ce6-PDD revealed cancers that were not visible with white light viewing and provided a visual contrast from surrounding tissues. Also, in vivo, Ce6-PDT remarkably reduced melanoma and pancreatic tumors in the mouse model. These findings could pave the way for a better understanding of the underlying processes of Ce6-PDT, making it an effective and safe candidate for use in human and veterinary applications to abolish various cancers.
Phytochemical Analysis and Binding Interaction of Cotton Seed Cake Derived Compounds with Target Protein of Meloidogyne incognita for Nematicidal Evaluation
Authors: Almutairi Fahad M. , Khan Amir , Ajmal Mohammad Rehan , Khan Rizwan Hasan , Khan Mohd Farhan , Lal Hira , Ullah Mohammad Fahad , Ahmad Faheem , Ahamad Lukman , Khan Arshad , Arif Hussain , Ayaz Ahmad M.
Published: December 2022

The root-knot nematode Meloidogyne incognita is one of the most damaging plant-parasitic nematodes and is responsible for significant crop losses worldwide. Rising human health and environmental concerns have led to the withdrawal of commonly used chemical nematicides. There has been a tremendous demand for eco-friendly bio-nematicides with beneficial properties to the nematode hosting plants, which encourages the need for alternative nematode management practices. The current study was undertaken to determine the nematicidal potential of cotton seed cake (CSC) against second-stage juvenile (J2) hatching, J2 mortality, and J2 penetration of M. incognita in tomato plants in vitro. J2s and egg masses of M. incognita were exposed to four concentrations (250, 500, 750, and 1000 mg/L) of CSC extracts. The higher J2 mortality and inhibition of J2 hatching were found at 1000 mg/L, while the least effective result was observed at 250 mg/L of the CSC extract. The CSC extract applied with the concentrations mentioned above also showed inhibition of J2 penetration in tomato roots; 1000 mg/L showed the highest inhibition of penetration, while 250 mg/L displayed the least inhibition. Using gas chromatography-mass spectroscopy, we identified 11 compounds, out of which 9,12-Octadecadienoic acid, Hexadecanoic acid, and Tetradecanoic acid were found as major compounds. Subsequently, in silico molecular docking was conducted to confirm the nematicidal behavior of CSC based on binding interactions of the above three major compounds with the targeted protein acetylcholine esterase (AChE) of M. incognita. The values of binding free energy are −5.3, −4.5, and −4.9 kcal/mol, observed for 9,12-Octadecadienoic acid, n-Hexadecanoic acid, and Tetradecanoic acid, respectively, suggesting that 9,12-Octadecadienoic acid binds with the receptor AChE more efficiently than the other two ligands. This study indicates that CSC has nematicidal potential that can be used to control M. incognita for sustainable agriculture.
Aerobic Capacity in Adults with Congenital Heart Disease: More than VO2peak, a Follow-Up Study
Authors: Ferri Kelly , Gich Ignasi , Guerra-Balic Myriam , Oviedo Guillermo R. , Doñate Maite , Parra Mireia , Carbonell-Prat Bàrbara , Dos-Subirá Laura , Serra-Grima Ricard
Published: December 2022

To control the development of people with congenital heart disease (CHD), it is important to follow their aerobic capacity (AC), especially when they exercise. This research aimed to study the progress of AC during a follow-up of adults with CHD. This is a longitudinal study which involved 127 adults with a mean age of 33.8 (11.1) years (57.5% female; 75 moderate CHD and 52 complex CHD) who had undergone two cardiopulmonary exercise tests (CEPT) in at least one year between the first and the second test. The AC and exercise performance (EP) (duration of exercise time, velocity and percentage of grade) were assessed using a ramp protocol over a treadmill. In a mean of 4.5 (2.0) years of follow-up, there was a significant decrease in AC. The VO2peak at baseline was 27.8 (27.7) mL/kg/min (82.9% (20.3%) predicted) versus 26.6 (7.8) mL/kg/min (79.3% (20.8%) predicted) at the end of follow-up. This decline was independent of the body weight increase. There was no significant difference in HRpeak and EP among periods. These results suggest a sign of favorable evolution of adults with CHD. More research is needed to study different factors that could contribute to AC reduction.
Chemically Modified Silicone Oil with Enhanced Tribological and Anti-Foaming Properties
Authors: Luan Xiaosheng , Zhang Enhui , Chen Yunlong , Ma Rui , Gong Kuiliang , Li Weimin , Wang Xiaobo
Published: December 2022

Two kinds of chemically modified silicone oil, diisooctyl phosphate-terminated silicone oil (UCP204) and dioctyl dithiophosphate-terminated silicone oil (UCT2003), were synthesized. The tribological properties of silicone oil were evaluated using an SRV tribometer, and the worn surface and chemical composition were examined by scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS). The friction coefficients of UCP204 and UCT2003 were reduced by approximately 62.7% and 56.7% compared with untreated silicone oil. The results indicated that the incorporation of phosphorus and/or sulfur could significantly enhance the tribological performance of modified silicone oil. Benefiting from their unique chemical structure, chemically modified silicone fluids also exhibit good dispersion stability and excellent anti-foaming properties, which are mainly attributed to the low surface tension properties imparted by the silicone backbone and the better dispersion stability provided by the dialkyl dithiophosphate group in chemically modified silicone fluids. It is also found that lubricants containing modified silicone oil remain clear after three months of storage and still maintain good anti-foaming properties.
The Influence of Mortar’s Poisson Ratio and Viscous Properties on Effective Stiffness and Anisotropy of Asphalt Mixture
Authors: Gajewski Marcin D. , Król Jan B.
Published: December 2022

This paper presents the results of a research study and analysis conducted to determine the degree of anisotropy of asphalt concrete in terms of its initial elastic properties. The analysis of asphalt concrete was focused on determining the effective constrained stiffness modulus in three mutually perpendicular directions based on the finite element method. The internal structure of the asphalt concrete was divided into the mortar phase and the mineral aggregate phase. Static creep tests using the Bending Beam Rheometer were conducted for the mortar phase to fit the rheological model. The aggregate arrangement and orientation were analysed using an image analytical technique for the mineral phase. The Finite Element Method (FEM) meshes were prepared based on grey images with an assumption of plane strain in 2D formulation. Using the FEM model, the tension/compression tests using selected characteristic directions were conducted, and the effective constrained stiffness moduli were estimated. This study showed a dominant horizontal direction for all coarse aggregates resulting from the normal force of the road roller and paving machines during laying and compaction on a road site. Depending on the values of the mortar’s mechanical parameters and the load direction, the effective stiffness modulus might differ by ±20%. Based on the FEM analysis, this result was proven and commented on through an effective directional modulus evaluation and a presentation of internal stress distribution. Depending on the shape and orientation of the aggregates, it was possible to observe local “stress bridging” (transferring stresses from aggregate to aggregate when contacting). Moreover, the rheological properties of the mortar were considered by assuming two limiting situations (instantaneous and relaxed moduli), determining the bands of all possible solutions. In the performed FEM analysis, the influence of the Poisson ratio was also considered. The analysed asphalt concrete tends to be isotropic when the Poisson’s mortar ratio is close to the value of 0.5, which agrees with the physical expectations. The obtained results are limited to particular asphalt concrete and should not be extrapolated to other asphalt mixture types without prior analysis.
Loading Rate and Temperature Interaction Effects on the Mode I Fracture Response of a Ductile Polyurethane Adhesive Used in the Automotive Industry
Authors: Perez Mael , Akhavan-Safar Alireza , Carbas Ricardo J. C. , Marques Eduardo A. S. , Wenig Sabine , da Silva Lucas F. M.
Published: December 2022

Due to their high elongation at failure and damping capacity, polyurethanes are one of the main types of adhesives used in automotive structures. However, despite the wide range of applications of adhesives, their fracture mechanics behavior is still poorly studied in the literature, especially when both the loading rate and ambient temperature change. Accordingly, the main aim of the current work is to deal with the research gap. In the current research, mode I fracture energy of a ductile polyurethane adhesive with adaptive properties for its industrial application is determined at different test speeds and temperatures. Tests were done at quasi-static, intermediate, and high-speed levels and each at three different temperatures, including low, high, and room temperature. Mode I fracture toughness was determined using DCB tests. Increasing the loading rate from quasi-static to 6000 mm/min was found to significantly increase the maximum strength of the tested DCBs (from 1770 N to about 4180 N). The greatest sensitivity to the loading rate was observed for the DCBs tested at room temperature, where the fracture energy increased by a factor of 3.5 from quasi-static (0.2 mm/min) to a high loading rate (6000 mm/min). The stiffness analysis of the DCB samples showed that the transition from below the Tg to room temperature decreases the bond stiffness by about 60%, while a further temperature increase (from 23 °C to 60 °C) has no significant effect on this parameter. Since polyurethane-bonded joints often experience a wide range of temperatures and loading rates in service, the obtained results can be used to design these joints more securely against such loading/environmental conditions.
Nonlinear Vibration of Electrostatically Actuated Microbeam
Authors: Ismail Gamal M. , Hosen Md. Alal , Mohammadian Mostafa , El-Moshneb Maha M. , Bayat Mahmoud
Published: December 2022

In this paper, an analytical technique based on the global residue harmonic balance method (GRHBM) is applied in order to obtain higher-order approximate analytical solutions of an electrostatically actuated micro-beam. To illustrate the applicability and accuracy of the method, a high level of accuracy was established for the analytical solutions by comparing the results of the solutions with the numerical solution as well as the already published literature, such as the variational approach (VA), Hamiltonian approach (HA), energy balance method (EBM), and homotopy analysis method (HAM). It is shown that the GRHB method can be easily applied to nonlinear problems and provides solutions with a higher precision than existing methods. The obtained analytical expressions are employed to study the effects of axial force, initial gape, and electrostatic load on nonlinear frequency.
Adverse Events Associated with Universal versus Targeted Antifungal Prophylaxis among Lung Transplant Recipients—A Nationwide Cohort Study 2010–2019
Authors: Crone Cornelia Geisler , Wulff Signe Marie , Helweg-Larsen Jannik , Bredahl Pia , Arendrup Maiken Cavling , Perch Michael , Helleberg Marie
Published: December 2022

Background: Invasive fungal infections in lung transplant (LTX) recipients cause substantial morbidity, but the best strategy for prevention has not yet been determined. We evaluated adherence to and rates of adverse events of universal versus targeted prophylaxis. Methods: All LTX recipients in the Danish National LTX Centre (2010–2019) were included. Before July 2016, universal voriconazole prophylaxis was used. After July 2016, only high-risk patients received targeted prophylaxis with posaconazole and inhaled amphotericin B. Proportions of triazole discontinuation, side-effects, off-target calcineurin-inhibitor (CNI) levels, and acute rejection were compared between the two periods. Results: Universal and targeted prophylaxis was initiated in 183/193 and 6/102 patients, respectively. Only 37% completed > 9 of the intended 12 weeks of voriconazole; 72% of discontinuations were due to hepatotoxicity. In the universal vs. targeted prophylaxis period, 89% vs. 72% (p < 0.001) patients had low CNI episodes, and 37% vs. 1% (p < 0.001) of these were associated with discontinuation of triazole; 40% vs. 14% (p < 0.001) had acute rejection; and 23% vs. 3% (p < 0.001) had acute rejection associated with low CNI episodes. Conclusions: Universal voriconazole prophylaxis was associated with high rates of discontinuation, mainly caused by hepatotoxicity. In comparison to the targeted posaconazole period, more patients had low CNI levels and acute rejection in the universal voriconazole period.
Using Social Media to Collect Dietary Information for Public Health Policy
Authors: Rycroft Catherine , Beer Sarah , Corrigan Nicola , Cade Janet Elizabeth
Published: December 2022

There is no regular, routine measurement of food and nutrient intake regionally in the UK. Our goal was to identify a method to support policy makers tracking the local population food intakes. The aim of this study was to test the feasibility of using social media to obtain a large sample in a short time, with a regional focus; collecting dietary information using online tools. A Facebook (FB) boost approach was used to recruit a regional (Yorkshire and Humberside) sample of adults to complete a brief online survey followed by a detailed measure of food and nutrient intakes for the previous day using myfood24®. The FB posts were boosted for 21 days and reached 76.9 k individuals. 1428 participants completed the main questionnaire and 673 participants completed the diet diary. The majority of respondents were older women. 22% of respondents reported experiencing moderate food insecurity during 2021. Overall nutrient values recorded were similar to national survey data. Intakes of fibre and iron were low. Despite some challenges, this study has demonstrated the potential to use social media, in this case Facebook, to recruit a large sample in a short timeframe. Participants were able to use online tools to report food and nutrient intakes. This data is relevant to local and national policy makers to monitor and evaluate public health programmes.
Assessing the Effect of Plant-Based Mince on Fullness and Post-Prandial Satiety in Healthy Male Subjects
Authors: Muhlhausler Beverly S. , Belobrajdic Damien , Wymond Brooke , Benassi-Evans Bianca
Published: December 2022

This study aimed to assess the effect of substituting plant-based mince for beef mince in a standard pasta meal on the amount consumed and on objective and subjective measures of post-prandial satiety. Healthy, adult males (n = 24) consumed a pasta lunch meal containing either plant-based or beef mince at separate visits, and the amount consumed measured at each visit. Perceptions of hunger, fullness and satisfaction were recorded and blood samples collected before and for 3 h after eating, when a buffet meal was provided. Participants consumed 586 kJ less of the pasta meal prepared with plant-based mince compared to beef mince (p < 0.05). Energy intake at the buffet meal and measures of fullness, satiety and satisfaction after the pasta meal were not different between plant and beef mince (p > 0.05). Post-prandial Glucagon-Like Peptide-1 (GLP-1), but not insulin or leptin concentrations, were lower after the plant-based pasta meal (p < 0.05). Our results suggest that the pasta meal containing plant-based mince was more satiating than an equivalent meal prepared with beef mince, and that this was not associated with greater energy intake at a subsequent meal occasion. Further studies that evaluate the longer-term effects of replacing meat with plant-based mince on energy intakes and explore the mechanisms underlying the lower consumption of the plant-based mince meal would be valuable.
Alpinetin Suppresses Zika Virus-Induced Interleukin-1β Production and Secretion in Human Macrophages
Authors: Wikan Nitwara , Potikanond Saranyapin , Hankittichai Phateep , Thaklaewphan Phatarawat , Monkaew Sathit , Smith Duncan R. , Nimlamool Wutigri
Published: December 2022

Zika virus (ZIKV) infection has been recognized to cause adverse sequelae in the developing fetus. Specially, this virus activates the excessive release of IL-1β causing inflammation and altered physiological functions in multiple organs. Although many attempts have been invested to develop vaccine, antiviral, and antibody therapies, development of agents focusing on limiting ZIKV-induced IL-1β release have not gained much attention. We aimed to study the effects of alpinetin (AP) on IL-1β production in human macrophage upon exposure to ZIKV. Our study demonstrated that ZIKV stimulated IL-1β release in the culture supernatant of ZIKV-infected cells, and AP could effectively reduce the level of this cytokine. AP exhibited no virucidal activities against ZIKV nor caused alteration in viral production. Instead, AP greatly inhibited intracellular IL-1β synthesis. Surprisingly, this compound did not inhibit ZIKV-induced activation of NF-κB and its nuclear translocation. However, AP could significantly inhibit ZIKV-induced p38 MAPK activation without affecting the phosphorylation status of ERK1/2 and JNK. These observations suggest the possibility that AP may reduce IL-1β production, in part, through suppressing p38 MAPK signaling. Our current study sheds light on the possibility of using AP as an alternative agent for treating complications caused by ZIKV infection-induced IL-1β secretion.
Performance of SALP Swarm Localization Algorithm in Underwater Wireless Sensor Networks
Authors: Huchegowda Yogeshwary Bommenahalli , Ningappa Aravind Bettadahalli , Kumar Chandramma Mallesh Naveen , Nanjappa Yashwanth
Published: December 2022

In underwater wireless sensor networks, the optimization strategies for localization might be seen as a new boon for the localization of sensor nodes (UWSNs). The techniques for optimization are those that repair the incorrect value, adapt it to the situation, and correct it. Because the algorithm could adapt to the constantly changing environment, it was widely used in terrestrial applications, and the same can be extended to the underwater environment with modifications. To address the localization issue that arises in UWSNs, the Underwater Salp Swarm Algorithm (USSA), a nature-inspired node localization algorithm, has been presented. With the help of this technique, an effort to discover a solution to the localization problem as an optimization problem is considered. The proposed algorithm is accessed in a simulated water environment. The energy is assigned to the anchor well as non-localized nodes, after deploying them in the simulated underwater network. The suggested algorithm is compared with other optimization algorithms, such as UPSO and UBOA, with reference to the computing time, localization accuracy, and the number of localized nodes. It is possible to localize a greater number of nodes in a much faster and more efficient way by considering the proposed algorithm.
Variability in Maturity, Oil and Protein Concentration, and Genetic Distinctness among Soybean Accessions Conserved at Plant Gene Resources of Canada
Authors: Fu Yong-Bi , Cober Elroy R. , Morrison Malcolm J. , Marsolais Frédéric , Zhou Rong , Xu Ning , Gahagan A. Claire , Horbach Carolee
Published: December 2022

Soybean (Glycine max (L.) Merr.) is one of the important crops in Canada and has the potential to expand its production further north into the Canadian Prairies. Such expansion, however, requires the search for adapted soybean germplasm useful for the development of productive cultivars with earlier maturity and increased protein concentration. We initiated several research activities to characterize 848 accessions of the soybean collection conserved at Plant Gene Resources of Canada (PGRC) for maturity, oil and protein concentration, and genetic distinctness. The characterization revealed a wide range of variations present in each assessed trait among the PGRC soybean accessions. The trait variabilities allowed for the identification of four core subsets of 35 PGRC soybean accessions, each specifically targeted for early maturity for growing in Saskatoon and Ottawa, and for high oil and protein concentration. The two early maturity core subsets for Saskatoon and Ottawa displayed days to maturity ranging from 103 to 126 days and 94 to 102 days, respectively. The two core subsets for high oil and protein concentration showed the highest oil and protein concentration from 25.0 to 22.7% and from 52.8 to 46.7%, respectively. However, these core subsets did not differ significantly in genetic distinctness (as measured with 19,898 SNP markers across 20 soybean chromosomes) from the whole PGRC soybean collection. These findings are useful, particularly for the management and utilization of the conserved soybean germplasm.
Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
Authors: Wani Shahid Ud Din , Masoodi Mubashir Hussain , Gautam Surya Prakash , Shivakumar H. G. , Alshehri Sultan , Ghoneim Mohammed M. , Alam Prawez , Shakeel Faiyaz
Published: December 2022

Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords and medically authorised human analogues made of silk have a long history of use in management. We describe the use of silk in the treatment of eye diseases in this review by looking at the usage of silk fibroin for eye-related drug delivery applications and medication transfer to the eyes. During this ancient art endeavour, a reduced engineering project that employed silk as a platform for medicine delivery or a cell-filled matrix helped reignite interest. With considerable attention, this study explores the present usage of silk in ocular-based drug delivery. This paper also examines emerging developments with the use of silk as a biopolymer for the treatment of eye ailments. As treatment options for glaucoma, diabetic retinopathy, retinitis pigmentosa, and other retinal diseases and degenerations are developed, the trans-scleral route of drug delivery holds great promise for the selective, sustained-release delivery of these novel therapeutic compounds. We should expect a swarm of silk-inspired materials to enter clinical testing and use on the surface as the secrets of silk are unveiled. This article finishes with a discussion on potential silk power, which adds to better ideas and enhanced ocular medicine delivery.
Diverted from Landfill: Reuse of Single-Use Plastic Packaging Waste
Authors: O’Rourke Kit , Wurzer Christian , Murray James , Doyle Adrian , Doyle Keith , Griffin Chris , Christensen Bernd , Brádaigh Conchúr M. Ó , Ray Dipa
Published: December 2022

Low-density polyethylene (LDPE) based packaging films mostly end up in landfill after single-use as they are not commonly recycled due to their flexible nature, low strength and low cost. Additionally, the necessity to separate and sort different plastic waste streams is the most costly step in plastics recycling, and is a major barrier to increasing recycling rates. This cost can be reduced through using waste mixed plastics (wMP) as a raw material. This research investigates the properties of PE-based wMP coming from film packaging wastes that constitutes different grades of PE with traces of polypropylene (PP). Their properties are compared with segregated individual recycled polyolefins and virgin LDPE. The plastic plaques are produced directly from the wMP shreds as well as after extruding the wMP shreds into a more uniform material. The effect of different material forms and processing conditions on the mechanical properties are investigated. The results of the investigation show that measured properties of the wMP fall well within the range of properties of various grades of virgin polyethylene, indicating the maximum possible variations between different batches. Addition of an intermediate processing step of extrusion before compression moulding is found to have no effect on the tensile properties but results in a noticeably different failure behaviour. The wMP does not show any thermal degradation during processing that was confirmed by thermogravimetric analysis. The results give a scientific insight into the adoption of wMP in real world products that can divert them from landfill creating a more circular economy.
Carbonised Human Hair Incorporated in Agar/KGM Bioscaffold for Tissue Engineering Application: Fabrication and Characterisation
Authors: Vitus Vieralynda , Ibrahim Fatimah , Shamsuddin Shamsul Azlin Ahmad , Razali Nuguelis , Noor Azlan Noor Anastasha Balqis , Zaman Wan Safwani Wan Kamarul
Published: December 2022

Carbon derived from biomass waste usage is rising in various fields of application due to its availability, cost-effectiveness, and sustainability, but it remains limited in tissue engineering applications. Carbon derived from human hair waste was selected to fabricate a carbon-based bioscaffold (CHAK) due to its ease of collection and inexpensive synthesis procedure. The CHAK was fabricated via gelation, rapid freezing, and ethanol immersion and characterised based on their morphology, porosity, Fourier transforms infrared (FTIR), tensile strength, swelling ability, degradability, electrical conductivity, and biocompatibility using Wharton’s jelly-derived mesenchymal stem cells (WJMSCs). The addition of carbon reduced the porosity of the bioscaffold. Via FTIR analysis, the combination of carbon, agar, and KGM was compatible. Among the CHAK, the 3HC bioscaffold displayed the highest tensile strength (62.35 ± 29.12 kPa). The CHAK also showed excellent swelling and water uptake capability. All bioscaffolds demonstrated a slow degradability rate (<50%) after 28 days of incubation, while the electrical conductivity analysis showed that the 3AHC bioscaffold had the highest conductivity compared to other CHAK bioscaffolds. Our findings also showed that the CHAK bioscaffolds were biocompatible with WJMSCs. These findings showed that the CHAK bioscaffolds have potential as bioscaffolds for tissue engineering applications.