bluuebunny/crossref_metadata_2025 huggingface dataset:
La sclerosi multipla in età pediatrica e adolescenziale
Authors: Carrozzi Marco , Iacono Alessandra , Gortani Giulia , Piscaglia Maria Grazia , Marchetti Federico , Barbi Egidio
Published: April 2023

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelin of the brain and spinal cord; it is characterized by recurrent episodes of demyelination in the central nervous system. Paediatric-onset multiple sclerosis (POMS) is a rare disease, with an estimated frequency of approximately 0.05-2.85 per 100,000 children. The diagnosis requires the spatial and temporal dissemination of the disease with clinical evaluation and with laboratory tests such as oligoclonal bands in the liquor and MRI of the brain and spinal cord. The treatment of the acute episode involves cortisone in high doses, then the immunomodulatory treatment (disease-modifying treatment - DMT) is started to prevent the recurrence of the episodes with consequent stabilization of the lesions that could anticipate the time of permanent disability. Hence, the paper aims to review the literature on POMS to guide physicians on the current understanding of its diagnosis and management.
COMPARATIVE ANALYSIS OF THE PERFORMANCE OF BRAKE FRICTION LININGS WITH FUNCTIONAL PROPERTIES
Authors: MELIKSETYAN N.G.
Published: April 2023

A comparative analysis of the performance of various brake friction linings with
functional properties. Friction brake linings of the code TIIR and JSC AZ URAL produced
in the Russian Federation and TRIBO produced in the Ukraine, which are widely used in
the brakes of Ural vehicles, were subjected to bench tests. A comparative analysis of the
performance of these materials and asbestos-free friction composites patented in Republic of Armenia and the Russian Federation with functional properties of the Bastenite type, created in the basic research laboratory “Tribology” of National Polytechnic University of Armenia, was carried out.
As a result of bench tests on the operational simulated operating parameters of drum
brakes of dual-purpose vehicles "Ural", it was found that in terms of braking efficiency,
braking efficiency loss and recoverability parameters, the material of the Bastenit-9 type
provides the necessary performance and meets the requirements of the international
standard SAE J 661 201211. In terms of wear resistance, the material of the Bastenit-9 type is superior to its analogues.
To organize the production of friction materials of the Bastenit type in Republic of
Armenia, it is proposed to conduct joint road tests with interested organizations of the
Russian Federation and Republic of Armenia.
FORMING THE REQUIREMENTS FOR EMOTION DETECTION METHODS
Authors: HARUTYUNYAN E.A.
Published: April 2023

In the technological age, emotion detection has gradually become a research hotspot
and one of the most important fields in human-computer interaction. Different proposed
technologies of recent years on emotion detection have been summarized and compared. The relatively often used emotion types are presented, including Paul Ekman's, Parrot’s, Circumplex model and Plutchik’s Wheel. Speech, Text, Facial Expressions, and Electroencephalogram were discussed as sources of emotions. 2 main sub-branches of emotion detection are discussed: unimodal and multimodal, which use the above sources. Each of these sources has its own advantages and disadvantages, and depending on the problem, the use of one may be more effective than that of the other. As a result, several important problems are highlighted, such as real-time data processing without external servers and devices, resource management, model creation for non-popular languages, etc. For model training a variety of datasets are used, some authors have even combined several for higher accuracy.
Data enhancement methods were used by all authors in order to reduce noise at the preprocessing stage. Although some sources claim that better results can be obtained with the unimodal method, the multimodal method, if properly processed, results in a higher accuracy system.
FORMING THE REQUIREMENTS FOR SIGN LANGUAGE DETECTION
Authors: GALSTYAN D.M.
Published: April 2023

Sign language is a way of communicating through body movements. Body language
recognition has been one of the most challenging research problems in the last few years.
Their recognition plays an increasingly important role due to the huge spread of digital
technologies.
With the development of the fields of deep learning and computer vision, researchers
have developed various automatic motion language recognition methods that can understand body movement.
The idea of this study is to examine the existing sign language recognition systems
in the world. These works are mainly divided into sensor-based systems and vision-based systems. Studies have shown that sensor-based tracking is more resource-intensive and difficult to implement than traditional image-based research, and there are also combinations of these two methods. As a result of this study, it can be seen that there are many sign languages in the world, most of which do not have their own databases available, and also dynamic gesture recognition systems still need new research to improve the results.
During the work, several points have been formed that can help improve the quality
of the work by adding studies and databases for unknown languages, using them also to obtain an acceptable accuracy of dynamic gesture detection, as well as ensuring the system work in real-time and use of few resources.
THE AGING INFLUENCE MINIMIZATION METHOD FOR OPERATIONAL AMPLIFIERS WITH THIN OXIDE TRANSISTORS
Authors: MELIKYAN V.SH. , GHUKASYAN S.A. , HARUTYUNYAN S.S. , KOSTANYAN H.T , VOSKANYAN G.A.
Published: April 2023

Nowadays CMOS technology feature size is being scaled aggressively. Supply voltage is not proportionally scaled, gate dielectric thickness is reduced and as a result, the devices are subjected to stronger electric fields, thereby causing stress on transistor. Stress causes aging degradation, which can lead to dramatic consequences on mobile devices, aircraft, military systems, or medical devices.
A method is proposed for designing two types of operational amplifiers with usage
of only thin oxide devices, which are protected from stress conditions, namely from aging
degradation. The proposed methods can also be implemented on other types of operational amplifiers.
SOLUTION OF ONE-PARAMETER GENERALIZED PALINDROMIC PROBLEMS
Authors: SIMONYAN S.H. , NURJANYAN A.V. , MELIKYAN A.V. , KHACHATRYAN M.G.
Published: April 2023

The issues on applying a computer program created on the language "Python" on the
basis of the developed methods for solving one-parameter generalized palindromic
problems are considered. The results of solving one model example are presented, and the
computational efficiency of the developed tools is shown.
Microbiological and Periodontal Status of Patients Enduring Orthodontic Treatment
Authors: Quraeshi Saima Sameer , Hussain Mudassir , Iqbal Shazia Sarwat , Haider Shajia , Soomro Saba Parveen , Khan Imran
Published: April 2023

Objective: To ascertain the probing depths, plaque scores and organism morphotypes in patients enduring orthodontic treatment, as well as the benzoyl-DL-arginine-naphthylamide test scores of periodontopathic bacteria, counting those of red complex bacteria Treponema denticola, Tannerella forsythia and Porphyromonas gingivalis. Place and Duration: In the Department of Community and Preventive Dentistry, Karachi Medical and Dental College, Karachi for one-year duration from January 2022 to December 2022. Methods: Plaque samples were taken from 26 patients in this prospective research at baseline and followed up at 30 days and four months following treatment after the appliance was removed. The periodontal pathogens were found using a benzoyl-DL-arginine-naphthylamide assay. The morphotypes were identified using dark field microscopy. At each test interval, the probing depths and O'Leary Plaque Index were evaluated to identify the patients' oral health and periodontal status. The Tukey's Honestly Significant Difference test and analysis of variance were used to analyze the data. Results: After the insertion of orthodontic appliances, there were significant rise in the probing depths, plaque score, and scores of benzoyl-DL-arginine-naphthylamide at each follow-up visit. But, after the appliances were removed, the levels went back to normal. Increases in large spirochetes (2.5%), small spirochetes (8.1%), fusiforms (6%), filaments (1%) and non-motile rods (10%) were observed during orthodontic therapy, according to dark field microscopy. Conclusion: Plaque accumulation, probing depth, and microbial activity are all higher in patients receiving orthodontic treatment, which may be a sign of periodontal destruction. The probing depth, benzoyl-DL-arginine-naphthylamide test score and plaque score all came back to baseline levels thirty days after the orthodontic appliance was removed. Keywords: Porphyromonas gingivalis, orthodontic brackets, bacterial adherence, and Treponema denticola.
Diagnostic Accuracy of Modified Alvarado Score (MAS) and Ohmann Scores (OS) in Diagnosing Acute Appendicitis
Authors: Rasheed Zahid , Sayyed Sauleha , Ali Imran , Hameed Fawad , Rizwan Muhammad , Naz Gul , Mirza Natasha Kanwal
Published: April 2023

In the field of General Surgery AA is the frequent clinical condition for which patients who need emergency surgery present with abdominal pain.1 Diagnosis of this pathology is made with the help of history, patient symptoms, and clinical exam and lab investigations. Ultrasonography (USG) and computed tomography (CT) images for acute appendicitis should be considered.2 Methodology: The purpose of the study is to compare the diagnostic accuracy of Modified Alvarado Score (MAS) and Ohmann Scores (OS) in diagnosing the pathology of Acute Appendicitis, while retaining histopathology as the basis for final diagnosis. A total of 411 patients were admitted via the Accidents & Emergency Department of Mayo Hospital Lahore, meeting the inclusion and exclusion requirements having the clinical diagnosis of acute appendicitis. For each patient, both Modified Alvarado and Ohmann scores were assessed prior to undergoing the procedure, i.e. open appendectomy. Abdominopelvic assessments and laboratory results were assessed and abdominal USG was performed in all patients. Biopsy of the removed appendix was sent for histopathology to Pathology Department of King Edward Medical University. Results: For the modified Alvarado and Ohmann score; sensitivity and specificity of was 89.74%, 90.48%, 85.13% and 80.95% respectively. The positive predictive value (PPV) and negative predictive value (NPV) for “modified Alvarado score” was 99.43% and 32.2% and for “Ohmann score” it was 98.81% and 22.67% respectively. Conclusion: Both scoring system are sensitive and specific enough for diagnosis of acute appendicitis. However, sensitivity and specificity of modified Alvarado score is higher as compared to Ohmann score. Keywords: Acute Appendicitis, Diagnostic Accuracy, Modified Alvarado Score, Ohmann Score, Histopathology.
Low-Pressure Laparoscopic Surgery is a Viable and Risk-Free Alternative to Standard Pressure for the Treatment of Benign Gall Stone
Authors: Ali Imran , Naz Gul , Sayyed Sauleha , Rasheed Zahid , Rizwan Muhammad , Hameed Fawad , Jameel Muhammad Khurram
Published: April 2023

When compared to the open cholecystectomy, laparoscopic cholecystectomy (LC) has the benefits of less post-operative pain and quicker return to work. However, up to 80% of individuals after laparoscopic surgery still experience significant pain and needing pain relief. Methodology: The reason for this research was to compare the results of LC performed with and without LPP. LC requires the surgeon to choose a pneumoperitoneum pressure that maximizes working space while avoiding unintended side effects. This study used a Randomized Controlled Trial (RCT) design, and it was done at the West Surgical Ward at Mayo Hospital in Lahore. The study enrolled 60 participants who met the inclusion criteria. The patients were split in two groups: Low-pressure pneumoperitoneum-LPP (Group A) (06-10 mm of Hg) and pneumoperitoneum at standard pressure (SPP) is part of Group B. (12-16 mm of Hg). All had opted for a LC to treat their symptomatic gallstone disease. At 4, 8, and 24 hours following surgery, the severity of postoperative shoulder pain (if present) was evaluated using a visual analogue pain scale (VAS). The frequency of postoperative nausea and vomiting was assessed at 4, 8, 12, and 24 hours. Results: The patients were 35.63 years old on average. Majority of these two groups has no complications. Based on the data, we discovered that the frequency of episodes of nausea/vomiting in both groups was very low and that only a few patients had bouts of nausea/vomiting in the 4 hours and 24 hour time intervals. Conclusion: We have come to the conclusion that LP laparoscopic surgery is a viable and risk-free alternative to SP laparoscopic operation for the treatment of benign gall stone disorders. Our findings lead us to the conclusion that LPP is a superior option for the LC since it reduces the post-operative pain in the shoulder and the risk of PONV while not significantly increasing the risk of intraoperative complications. Keywords: Benign Gall Stone, Treatment, Low-Pressure Laparoscopic Surgery,
Progesterone: A Hope to Prevent Preterm Births & Reduce Perinatal Mortality
Authors: Rafiq Tanzila , Hayat Naheed , Uzma Syeda , Masher Maria , Fatima Naheed , Rafi Piya Muhammad Musammat
Published: April 2023

Objectives: To assess and compare the maintenance of tocolysis in preterm labor by using vaginal and intramuscular progesterone. Study design: Randomized controlled trial. Settings and study duration: Department of Obstetrics & Gynecology, Civil Hospital, Bahawalpur between 12th March 2019 and 11th September 2019 Materials & Methods: A total of 96 women ranging from 18 and 40 years of age presented with threatened preterm labour, at gestational age between 28 to 36 weeks were included. Out of total, Patients having multiple pregnancy, preterm premature rupture of membrane, medical disorders, IUGR and APH were excluded .All patients were given acute tocolytic therapy with oral nifedipine. Then they were divided in 2 groups. In the Group A, vaginal progesterone (Cyclogest 200mg) was given daily while in group B patients, a single intramuscular injection(IM) of 250 mg of 17-alpha-hydroxyprogesterone caproate (17 OHP) was given weekly. All patients in both groups were evaluated upto the delivery and efficacy was documented. Results: The mean age was 29.34 ± .4.92 years. The gestational age was from 28 to 36 weeks with mean age of 30.91 ± 1.44 weeks. Efficacy ( no preterm birth) was seen in 42 (87.50%) in group A (vaginal progesterone) and 34 (70.83%) in group B (intramuscular progesterone) with p-value of 0.044. Conclusion: The verdict of the study is that for preventing preterm birth the efficacy of vaginal progesterone is better than intramuscular. Keywords: vaginal progesterone, preterm birth, perinatal mortality, preterm labour, hydroxyprogesterone, tocolytic maintenance.
Factors Leading to Prolonged Hospital Stay in Patients Undegoing Laproscopic Cholecystectomy at Tertiary Care Hospital, Karachi
Authors: Erum Unaiza , Lakhani Murk , Kazim Erum , Naeem Bushra Kiran , Baig Mirza Arsalan , Shahab Hassan
Published: April 2023

Objective: To determine the frequency of prolonged hospital stay and its associated factors in patients undergoing laparoscopic cholecystectomy for symptomatic cholelithiasis at Tertiary Care Hospital, Karachi. Methods: After the ethical approval from College of Physicians and Surgeons Pakistan, this descriptive study, was conducted at Department of Surgery, Civil Hospital, Karachi, from 08-06-2021 till 08-01-22. Data was prospectively collected from patients after taking a verbal consent. 88 patients who met the diagnostic criteria were included. Quantitative data was presented as simple descriptive statistics giving mean and standard deviation and qualitative variables was presented as frequency and percentages. Effect modifiers were controlled through stratification to see the effect of these on the outcome variable. Post stratification chi square test was applied taking p-value of ≤0.05 as significant Results: A total of 88 patients who met the inclusion and exclusion criteria were included in this study. Mean age, duration of surgery, BMI, height and weight in our study was 50.14±10.49 years, 75.25±20.87 minutes, 29.66±2.56 kg/m2, and 152.3±10.28 cm and 76.9±8.87 kg. Out of 88 patients, 26 (29.5%) and 62 (70.5%) had and did not have prolonged hospital stay. Conclusion: It is possible to shorten the length of time spent in the hospital after surgery if the patient is carefully evaluated beforehand, the operation is performed with precision, and the patient is well cared for afterward. Keywords: Prolonged hospital stay, laparoscopic cholecystectomy, symptomatic cholelithiasis and factors.
The Effect of Two Different Root Canal Sealers on Post Obturation Pain
Authors: Shahroz Nabiya , Surti Sumayya , Zaidi Irha Hussain , Mehdi Mohammad Aun Ali , Sajjad Shahroz , Noor Zain
Published: April 2023

Objective: The purpose of this research was to evaluate the effectiveness of various root canal sealers in reducing postoperative pain and the need for analgesics. Methods: The asymptomatic necrosis and apical periodontitis of 60 single-rooted teeth were studied by randomly assigning them to 2experimental groups (n=30) according to the root canal sealer: AH Plus and MTA Fillapex. Two appointments were needed to complete the endodontic treatment, and calcium hydroxide was employed as the intracanal dressing. The patients were asked to assess the severity of their discomfort as no pain, slight and moderate pain. After 24 hours, 48 hours, and 7 days, patients rated their discomfort on a scale from 1 to 4. The use of pain relievers was also documented. Postoperative pain and the requirement for analgesia were compared using the t-test. Results: The Mean±S.D of the participants age in AH plus and MTA Fillapex group was 39.1±9.4 and 43±9.2 years. Overall, 62% were female and 38% were males were included in the present research. Overall, 37% of the cases (22 patients) had postoperative discomfort after 24 hours, with the number decreasing to 18% (11 patients) after 48 hours. After 7 days, no one in either of the groups had any discomfort. There were no statistically significant differences between groups in the occurrence or severity of postoperative pain or in the use of analgesics at any of the assessment points. Conclusion: Similar rates of postoperative discomfort and the requirement for analgesics were seen with the use of either AH Plus or MTA Fillapex for root canal filling. Keywords: Pain, Postoperative; Root Canal Obturation; Clinical Study
Short Term Outcome of Urethral Meatal Stenosis Surgery in Males
Authors: Inam Qazi Adil , Ali Ashfaq , Chatta Tasawar Hussain , Arshad Furqan , Tahir Tufail Hussain , Shabbir Hasnat
Published: April 2023

Background: MS is one of the common urological problems that is acquired and is faced by urologists as well as pediatric surgeons. Symptomatic boys are offered meatoplasty or meatotomy as a procedure of daycare under the influence of any anesthesia for the treatment of meatal stenosis. However, there is scarcity of literature on outcome of these surgical procedures in Pakistan. Objective: To determine the short-term Outcome of urethral meatal stenosis surgery in males was the objective of this study. Methodology: this prospective study including 50 male patients with urethral metal stenosis was conducted in department of urology, Aziz Bhatti Shaheed Hospital, Nawaz Sharif Medical College Gujrat, from June 2017 to June 2022. All patients underwent meatotomy. Operative findings and success rate were recorded. Results: Mean age of patients was 8.42±3.91 years. All patients were male. Pre-operatively, 36% patients had Meatal stenosis, 2% Meatal stenosis with incomplete circumcision, 8% Moderate meatal stenosis, 2% Narrowed external urethral meatus, 40% Pinhole meatus, 4% Pinhole sub-coronal meatus, 2% Pinhole external meatus, 4% Severe meatal stenosis and 2% patients had Sub-coronal hypospadiasis Pinhole meatus. The success rate is 100% in our study. Conclusions: Success rate of meatotomy in urethral meatal stenosis is high in male children and younger males. Keywords: meatal stenosis; Outcome; meatotomy
Compare the Efficacy of Ipratropium Bromide with Salbutamol and Salbutamol Alone in Recurrent Wheezes in Children with Asthma Presenting to LRH, Peshawar
Authors: Ahmad Furqan , Akhtar Sohail , Haider Zulqarnain , Nafis Sana , Gul Mujtaba , Hussain Ghulam , Din Nizam Ud , . Faiza , Badshah Fazal
Published: April 2023

Objective: Evaluate the effectiveness of Ipratropium Bromide in combination with Salbutamol and Salbutamol alone for the treatment of recurrent wheezes in children with asthma who seek care at LRH, Peshawar. Methods: After the approval from the institution review board, this randomized controlled trial was performed at Department of Pediatrics, LRH, Peshawar, from 7th January 2021 to 7th July 2021. A total of 128 patients who met the inclusion criteria were recruited from the Department of Pediatrics at LRH Peshawar. In Group A, 64 patients were given Ipratropium Bromide in addition to Salbutamol, whereas in Group B, 64 patients were given Salbutamol alone. In group A, children were subjected to salbutamol 2.5 mg thrice a day plus ipratropium bromide 125 ug 8 hourly during the exacerbation episode. In group B, children were subjected to 2.5 mg of salbutamol thrice a day during the exacerbation episode. Patients were contacted three months later to assess progress, and outcomes were recorded using a custom-made proforma. Results: 21.9% of the children were between age 1-2 years, while and 78.1% children were between 3-5 years of Age. Mean age was 4.56±1.357 in both the study groups. 0ver all there were 70.3% male children and 29.7 % were females. In 27.3% of the children duration of the disease was 6 months and 72.7% have more than 6 months. Most of the participated children have weight between 16-20 kg (30.5%), followed by 26.6% have weight more than 30kg, followed by 21.1% have weight between 21-25kg. in 56.2% of the children had a family history of asthma, while 43.8% had no family history of asthma. Group wise distribution of efficacy among 128 children were analyzed as children in Group A (Ipratropium Bromide with Salbutamol) showed 45% decrease number of wheezing episodes and Group B (Salbutamol alone group) showed 51.5% decrease number of wheezing episodes Conclusion: Our research reveals that the addition of ipratropium bromide to salbutamol for the treatment of mild to moderate asthma attacks in children does not improve outcomes over the use of salbutamol alone. Keywords: Efficacy of Ipratropium Bromide with Salbutamol and Salbutamol alone, Recurrent wheezes, Children with asthma
The Issues of Women’s Emancipation in Elpis Kesaratsian’s Essay "Exercising the Right is not Audacity"
Authors:   Institute of Literature after Manuk Abeghian Academy of Sciences of Republic of Armenia, Hambardzumyan Naira
Published: April 2023

XIX դ. արևմտահայ գրականության մեջ հայ առաջին կին խմբագիր և գրող Էլպիս Կեսարացյանի «Իրավունքն ի գործ դնելը յանդգնություն չէ» (1862) էսսեն տպագրվել է նրա հիմնադրած և հրատարակած «Կանանց մասին և կանանց համար» առաջին հայալեզու «Կիթառ» հանդեսում (Կ. Պոլիս, 1861-1863), որի կարգախոսն էր՝ «Հրավեր հայկազն օրիորդաց»: Կնոջ գրավոր տեքստի երկու տարբեր ենթամակարդակները շարժվում են դեպի սուբյեկտիվացման գործընթաց անգիտակից վիճակի միջով: Հեղինակը ստեղծում է իր ներկանացի և ներսուբյեկտիվ լեզուն, ինչն ուշագրավ է իմացաբանական, պատմափիլիսոփայական, իմաստաբանական հիմնախնդիրների տիրույթում։ Կեսարացյանի էսսեներում արտացոլված՝ կին-տղամարդ միջանձնային և սոցիալական հարաբերությունները ոչ թե պարզունակ նկարագրություններ կամ հարցադրումներ են նրանց դերի և տարբերակման վերաբերյալ, այլ առավելապես հասարակության, կրթության, դաստիարակության մեջ կնոջ դերի, իրավունքների, տղամարդկանց հիերարխիայի, իշխանության, կին-տղամարդ փոխհարաբերությունների, նրանց առաջնահերթությունների և այլ խնդիրների քննություն, ուստի հոդվածում առաջին պլան են մղվում ոչ միայն մեթոդական, այլև գաղափարական դրույթները։ Эссе первой армянской писательницы и редактора Элпис Кесарацян «Внедрение права не является дерзостью» (1862) было опубликовано в первом армяноязычном журнале «о женщинах и для женщин» – «Китар» («Кифара»). Журнал издавался в Константинополе в 1861-1863 годах под редакцией Элпис Кесарацян. Воспроизведенные в эссе Э. Кесарацян межличностные и социально-общественные отношения между женщиной и мужчиной не являются простым описанием их ролей и дифференцирующих признаков, не содержат в себе простой постановки вопроса, а представляют собой анализ роли женщины в обществе, ее образования, воспитания, права, ее места в маскулинной иерархии, властной вертикали «женщина-мужчина» и их приоритетов и т.д., выдвигая на первый план не только методологические, но и идеологические установки. The research deals with the interpretation of women’s issues in the 19th century Western Armenian literature and aims to investigate the Armenian female author Elpis Kesaratsian’s essay "Exercising the Right is not Audacity" (1862) published in the first Armenian language journal "about women and for women" "Guitar" with the slogan "an invitation for Armenian young women" established and edited by Kesaratsian during 1861-1863 in Constantinople. The study has led to conclusion that the interpersonal and social relations reflected in Kesaratsian’s essays are not primitive descriptions or primitive questionings on their role and differentiation, but rather an examination of the role of women in society, edu-cation, upbringing, rights, relations with the male hierarchy, male-female authorities, their priorities, and other issues. Therefore not only methodological but also ideologi-cal provisions are pushed to the forefront.
ՀՀ ուսանողների զբաղվածության և աշխատանքի ապահովման նոր մոդել
Authors: Եղիազարյան Սյուզաննա
Published: April 2023

Հոդվածում քննված հիմնահարցի առնչությամբ կատարված վերլուծությունից եկել ենք այն համոզման, որ ՀՀ ուսանողների զբաղվածության և աշխատանքի ապահովման երաշխիք կարող են դառնալ բուհ-գործատու համալիր համագործակցության մոդելի մշակումը և կատարելագործումը: Առաջարկվող մոդելը մշակվել է՝ հիմք ընդունելով այս ոլորտում միջազգային հաջողված փորձը և համանման մոդելները, հաշվի է առնվել նաև կանխատեսումային մոտեցումը: Արդեն գոյություն ունեցող մոդելների հիմնական տարրերը հաշվի առնելով՝ փորձ է արվում դրանք համալրել նոր տարրերով, մասնավորապես բուհ-աշխատաշուկա համագործակցության շղթան ընդլայնվում է, որի մի օղակն է դառնում նաև դպրոցը: Քննարկվող մոդելի իրականացումը ենթադրում է փոխազդող կառույցների լայն շրջանակ, որը ներառում է պետական կառույցներ և ենթակառուցվածքներ, աշխատաշուկայի պետական ու մասնավոր հատվածներ, ոլորտային մասնագետներ ու գործատուներ:
Развитие и совершенствование модели комплексного сотрудничества вуз-работодатель может стать гарантией трудоустройства и занятости студентов РА. Предлагаемая модель была разработана на основе успешного международного опыта в этой области и аналогичных моделей с учетом прогностического подхода. Исходя из основных элементов уже существующих моделей предпринимается попытка дополнить их новыми элементами, в частности, расширяется цепочка взаимодействия вуз-рынок труда, звеном которой становится и школа. Реализация обсуждаемой модели предполагает наличие широкого круга взаимодействующих структур, в который входят: государственные структуры и инфраструктуры, государственный и частный секторы рынка труда, отраслевые специалисты и работодатели.
From the analysis made in relation to the issue examined in the article, we came to the conviction that the development and improvement of the university-employer complex cooperation model can become a guarantee of the employment and job security of RA students. The proposed model was developed based on successful international experience in this field and similar models, and the predictive approach was also taken into account. Having in mind the main elements of the already existing models, an attempt is made to supplement them with new elements, in particular, the chain of university-labor market cooperation is expanding, of which the school also becomes a link. The imple-mentation of the discussed model implies a wide range of interacting structures, which includes: state structures and infrastructures, public and private sectors of the labor market, sector specialists and employers.
The scenario of clinical research after the COVID-19 pandemic: assessment of regulatory aspects based on Anvisa
Authors: Carvalho Rocha Alves da Silva Juliana
Published: April 2023

Clinical research is a study with human subjects to test the efficacy and safety of an intervention. The phase III study, as it has a larger number of participants and has more controls, is the main study to be presented as proof of efficacy and safety in registering products with Anvisa. With the advent of the global Covid-19 pandemic, it was possible to observe a significant increase in clinical studies being carried out worldwide. For this, this study was divided into three parts i. quantitative assessment of the attractiveness of studies in Brazil after the Covid-19 pandemic; ii. qualitative assessment of studies in Brazil after the Covid-19 pandemic, describing their main characteristics; iii. to assess whether the drugs registered in Brazil, for Covid-19, had their clinical trials carried out with an arm in Brazil. In this analysis, it was possible to identify that, in Brazil, the number of clinical trials increased, but not significantly. However, analyzes of DDCMs and DEECs, considering drugs indicated for Covid-19, by Anvisa, increased by more than 100%, reinforcing that clinical research carried out in Brazil, during this period, had the interest of registering drugs or changing their bulls.
Chronic effect of bioresonance therapy on cardiovascular risk factors and physical activity pattern in the elderly: a randomized clinical trial
Authors: Mattera Fernando Otávio Pires , Candeloro Bruno Moreira , Mora José Alfredo Ordenes , Guiguer Elen Landgraf , Correa Maria Elizabeth da Silva Hernandes , Carácio Flávia Cristina Castilho , Detregiachi Cláudia Rucco Penteado , Chagas Eduardo Federighi Baisi
Published: April 2023

The aim of the study was to analyze the effect of 12 months of bioresonance therapy on physical activity behavior and cardiovascular risk factors in the elderly. A randomized, parallel, double-blind clinical trial was carried out in a sample of 20 elderly people. Bioresonance therapy was performed using QUANTEC® PRO. Data on gender, sex and morbidities were obtained. As cardiovascular risk factors, body composition, blood pressure and biochemical profile were analyzed. The behavior change stage related to physical activity was verified by the transtheoretical model and the physical activity pattern evaluated by the Baecke questionnaire. The treatment group showed a significant reduction in total cholesterol, triglycerides, blood glucose, LDL-c and non-HDL-c, and an increase in HDL-c and physical activity and physical exercise scores. The placebo group, showed a regression in the behavior stage for physical activity. Based on the results, we conclude that instrumental biocommunication therapy using QUANTEC® can make a significant contribution to the health of the elderly, particularly in increasing physical activity level, maintaining blood glucose levels and improving the lipid profile.
Bolonjska reforma sveučilišta i pitanje sreće u visokom obrazovanju
Authors: Sertić Marija
Published: April 2023

Rad obrađuje neke od pozitivnih i negativnih aspekata Bolonjskog procesa pri čemu je istraživački akcenat stavljen na koncept sreće kod studenata. Kvantitativnom analizom sadržaja deset dokumenata koje su rezultat ministarskih konferencija za visoko obrazovanje u razdoblju od 2001. do 2020. godine ustvrdili smo kako Bolonjska reforma ne posvećuje izričit i direktan interes za koncept sreće i dobrobiti studenata. Štoviše, pojmovi sreća, sreća studen(a)ta i dobrobit studen(a)ta ne spominju se ni u jednom od tih dokumenata. Potrebito je da visokoobrazovne institucije omoguće studentima stjecanje profesionalnih i stručnih kompetencija i prikladno osposobljavanje za tržište rada, ali i da im se osiguraju prilike za osoban razvoj i za istraživanje i evaluiranje determinanti sretnog, smislenog i dobrog života. U tu svrhu rad elaborira neke od stavaka ključnih za ljudsku sreću, a koje su nedovoljno zastupljene u europskoj reformi visokog obrazovanja na štetu osobnog razvoja studenata. Rad je podijeljen u četiri djela. Prvi dio razlaže Bolonjsku deklaraciju i neke od ciljeva Bolonjskog procesa. Drugi dio analizira pozitivne i negativne aspekte Bolonjskog procesa. Treći dio provodi kvantitativnu analizu sadržaja deset dokumenata koji su rezultat ministarskih konferencija i istražuje koncept sreće i dobrobiti, dok četvrti dio na temelju etičke teorije objektivne istine razvija određena rješenja kako bi se sreći i dobrobiti studenata unutar visokog obrazovanja posvetila adekvatnija pozornost.
Reacción liquenoide oral en joven con policonsumo de sustancias psicoactivas. Reporte de caso clínico
Authors: Espinoza Palma Alicia Samanta , Paz Betanco Manuel Amed , Téllez Castillo Evert Miguel , Herrera Rodríguez Emiliano Andrés
Published: April 2023

Las lesiones liquenoides orales son parte de un grupo de lesiones de mucosa oral descritas como estados patológicos con potencial premaligno, relacionadas a factores locales y hábitos de consumo, que incluyen abuso de drogas. Considerando que el consumo de sustancias psicoactivas es una preocupación creciente entre población joven y existen reportes de aumento en la incidencia de lesiones de mucosa oral y tumores de la cavidad oral en este mismo grupo etario; se ha convertido en una prioridad de salud pública la atención y control de uso de sustancias en muchos países, por sus implicaciones sociales y económicas. El objetivo del estudio fue caracterizar clínica e histopatológicamente lesiones de mucosa oral encontradas como hallazgo eventual en paciente con policonsumo de sustancias psicoactivas, evidencia que es parte de un estudio epidemiológico de mayor envergadura en un grupo caracterizado como población de jóvenes en riesgo de exclusión social en León, Nicaragua. Presentación de caso de paciente masculino de 24 años, historial de policonsumo de sustancias desde hace diez años, actualmente en rehabilitación ambulatoria. Al examen clínico intraoral se encontró lesión blanquecina en toda la extensión de carrillos de forma bilateral. La biopsia mostró resultados compatibles con lesión liquenoide oral, a 6 meses de control se evidencia evolución favorable con reducción del 30% de lesiones. Conclusión: Las lesiones con potencial premaligno requieren modificación y control de hábitos de consumo, así como observación de la evolución de las lesiones cada 6 meses por equipos multidisciplinarios.
Principales riesgos de seguridad en computación móvil en la nube: una revisión de la literatura
Authors: Mendoza de los Santos Alberto , Ríos Reyes Jairo Aldair , Vásquez Chiclayo Renzo Yampier
Published: April 2023

La computación móvil en la nube está expandiéndose entre los usuarios de dispositivos móvil, brindando una plataforma para sus servicios dentro de estos dispositivos. El presente documento expone los principales riesgos de seguridad que existen en la computación móvil en la nube, desarrollando y describiendo lo siguiente: seguridad de los datos, seguridad de dispositivos, seguridad en la red móvil y seguridad en la nube, determinantes de robo de información y la vulnerabilidad de autenticación; se presentan los principales riesgos a los cuales se enfrentan la computación móvil en la nube, sin embargo existen muchas más vulnerabilidades y se brinda para la investigación de futuros lectores.
Navigating the Complex Landscape of COVID-19 Vaccine Hesitancy in Asia: Identifying Key Determinants and Strategies for Improvement
Authors:   University of Tokyo, Kyoto-Japan, Murakami Yukio W.
Published: April 2023

Most LMICs have been slow to receive and distribute vaccines, which are much more available in high-income countries, prompting critiques of global vaccine inequity, which were exacerbated with the distribution of so-called booster shots in high-income countries in the autumn of 2021. Access issues, coupled with vaccine hesitancy, can have catastrophic effects. Vaccination against the novel coronavirus is one of the most effective strategies for combating the global Coronavirus disease (COVID-19) pandemic. However, vaccine hesitancy has emerged as a major obstacle in several regions of the world, including Asia. The COVID-19 pandemic has necessitated the rapid development and distribution of vaccines worldwide. However, vaccine hesitancy, particularly in Asia, poses a significant challenge to achieving herd immunity and controlling the pandemic. This study aims to identify the key determinants of COVID-19 vaccine hesitancy in Asian populations and develop targeted strategies to improve vaccination uptake. A comprehensive review of literature from 2019 to 2020 was conducted, focusing on sociocultural, political, and healthcare system factors that contribute to vaccine hesitancy in the region. Findings reveal that cultural and religious beliefs, misinformation and distrust in government and healthcare systems, and logistical and accessibility issues significantly impact vaccine uptake. To address these challenges, the study proposes strategies such as engaging with community leaders, improving communication, building public trust, and addressing logistical and accessibility barriers. By comprehensively understanding and addressing the determinants of COVID-19 vaccine hesitancy in Asia, the public health community can navigate the complex landscape and facilitate higher vaccination rates, ultimately contributing to the global control of the COVID-19 pandemic. Keywords: COVID-19 vaccine, Vaccine hesitancy, Determinants, Strategies for improvement, Asia
The Tongue: Perception versus Physiology
Authors: Nair Angelika
Published: April 2023

In this article, the author explores the tongue in light of recent science and explains the practical impact of this research on singing voice pedagogy. After a historical survey writings by García, Lehmann, Vennard, Appelman, Miller, and Ladefoged, the author summarizes her own studies of the tongue through the use of MRI and ultrasound technology. The author advocates rethinking traditional pedagogic maxims associated the tongue and argues for recasting verbiage in a way that dovetails art and science.
Between Time and Space: Coordination of Articulator Movements in the Motor Cortex
Authors: Moss Erickson Heidi
Published: April 2023

Singing is the most complex human motor behavior involving the seemingly instantaneous coordination of over 100 diverse muscles. The perceived spontaneous sound production requires precise control in a tight timing window at the level of milliseconds. The synchronous recruitment is a wonder of motor prediction, with calculations, signals, and even some muscle activity occurring prior to any onset of sound. Recent research in neuroscience, using bold in vivo approaches to dissect how the tongue, lips, and jaw are coordinated in the brain, reveal a dynamic relationship between timing, location, and order. Singers and teachers can integrate ideas from this research to generate more targeted pedagogy.
Music Reviews
Authors: Roland-Silverstein Kathleen
Published: April 2023

Review of anthologies by women composers and editors; Marklund ""Arien"" for tenor and bass/ Rosephanye Powell ""Langston Dreams""/ Furore publishers, Arien for Soprano, women composers
Recent Research in Singing
Authors: Simonson Donald
Published: April 2023

The following list of recent research in singing is a brief sampling of dissertations/theses published during the last year. It is by no means comprehensive and reflects only a small fraction of the available documents. If you have published recent research in singing, voice pedagogy, voice science, vocal repertoire, pedagogic methodology, or other topics of interest to the membership of NATS, please send citations and abstracts to Donald Simonson at drs@iastate.edu for review and possible inclusion in future columns.
The Grand Finale
Authors: Edwin Robert
Published: April 2023

“The Grand Finale” marks Robert Edwin’s last entry as an Associate Editor of the NATS Journal of Singing shepherding the “Singing A Cappella to Zydeco” column. The piece is a short summary of his performing, writing, and teaching career, one that covers almost sixty decades, as well as reflections on and thanks to those who helped him on his professional journey.
The Listener’s Gallery
Authors: Berg Gregory
Published: April 2023

A survey of the Kennedy Center's Digital Stage, a review of a CD of 21st century songs of longing, and a look at the recorded legacy of several artists we lost in 2022, including Maria Ewing, Angela Lansbury, and composer Ned Rorem.
Determinants of goodwill: Empirical study from emerging economies
Authors: Chelba Ancuța-Anisia , Melega Anatol , Grosu Veronica
Published: April 2023

Goodwill is increasingly receiving the interest of investors, auditors and other users of financial statements, therefore the need for comprehensive information on this topic has grown over time. The aim of this article is to analyze the determinants of goodwill in companies from emerging economy countries. The research is structured in two stages. The first stage of the research consists of a bibliometric analysis of the literature that is focused on the goodwill topic. The second part of the research consists in building an econometric model in order to assess the determinants of goodwill based on data reported by firms in emerging economy countries in 2021, namely the data reported by 21,977 companies from 100 emerging economy countries, structured into 94 industries. The obtained results are represented by the development of an econometric model that shows the implications of net profit, Economic Value Added (EVA), Earnings before Interest, Taxes, Depreciation and Amortization (EBITDA) and of research and development (R&D) expenses on goodwill fluctuations and vice versa. The results of our research highlight the fact that goodwill fluctuation is generated by the fluctuation of net profit, EVA, EBITDA and less by the R&D expenses. This study adds value to the literature by treating the subject differently, analyzing and evaluating the relationship between net profit, EVA, EBITDA, R&D expenses and goodwill.
Does good financial behavior reduce the negative impact of financial fragility on individuals’ financial optimism? The never-ending Lebanese crisis case
Authors: Mawad Jeanne Laure
Published: April 2023

This study aims to investigate the level of logistical coordination and the state of coordination mechanisms in procurement activities among enterprises involved in supply chains. The research was conducted through a comparative analysis of statistical data obtained from a survey of businesses between July and October 2021. The study proposes a method for identifying general and individual performance indexes for partner companies' interactions by examining joint planning, synchronized documentation, coordinated operational procedures, and resource integration. This method is relevant to both logistics theory and the practical activities of supply chain participants. The research highlights the evolution of metrics used to evaluate the extent of coordination mechanisms employed by businesses in their procurement activities. Based on the selection criteria, an assessment scale is proposed to determine the level of logistical coordination in supply chain companies' procurement activities. The findings offer insights into the development of coordination mechanisms for organizations across various sectors (industrial, trading, freight forwarding), focusing on their scientific significance and impact on the competitiveness of consolidated supply chains. This study contributes to the literature by providing a comprehensive understanding of logistical coordination and coordination mechanisms in procurement activities among supply chain enterprises, as well as offering a practical assessment scale for evaluating logistical coordination levels.
Comprehensive Measurement of Digital Economy in Anhui Province
Authors: Wen Ya
Published: April 2023

Digital economy is an emerging economic development mode, which has brought new vitality to the development of social real economy and promoted the development of regional economy. In this context, Anhui Province also put great efforts into the construction of digital economy, made great efforts to break through the core technology of digital economy, and constantly expanded the scale of digital economy, achieving remarkable results. Taking Anhui Province as the research object, this paper constructs a comprehensive evaluation index system of digital economy development from three aspects: digital infrastructure, digital industry development and digital development environment, and uses entropy method to measure the overall development level of digital economy in each city and Anhui province. The study found that there are still big differences in the level of digital development among different cities, but most cities have large space for digital economy development and good prospects. Anhui's overall digital economy development tends to balance, the comprehensive level has also achieved a great leap. Finally, according to the evaluation results, combined with the development advantages and characteristics of Anhui digital economy, put forward operational suggestions.
Research on the Influence of Supply Chain Finance on Enterprise Operation Performance Under the Background of Digital Transformation
Authors: Xu Zimei
Published: April 2023

In the economic market, small and medium-sized enterprises are the most solid, the most active and the largest entity for promoting economic development, stimulating the demand for innovation, improving people's lives and increasing employment. However, the problem of financing constraint is always the shackle that restricts the development of small and medium-sized enterprises. As a strong support for national development, the integration of the real economy and the financial supply side has been in constant friction. Efforts should be made to create a sound financing ecology, and further promote the solution of the financing difficulties of the real economy, especially for micro, small and medium-sized enterprises. In reality, the shortage of operating capital is always the main factor restricting the improvement of enterprise operation performance. In view of this situation, supply chain finance is regarded as an effective way to solve the financing problems of small and medium-sized enterprises by the theoretical circle and the industrial circle. Supply chain finance, as a new financing solution, helps to optimize the allocation of resources and funds between the upstream and downstream organizations of the supply chain, and gradually becomes an important way to alleviate the shortage of operating funds for small and medium-sized enterprises. This paper systematically reviews the relationships among supply chain finance, supply chain integration, enterprise digital transformation and enterprise operation performance, and reviews the information asymmetry theory and transaction cost theory.