bluuebunny/crossref_metadata_2025 huggingface dataset:
Monocyte/Lymphocyte Ratio and MCHC as Predictors of Collateral Carotid Artery Disease—Preliminary Report
Authors: Urbanowicz Tomasz , Michalak Michał , Olasińska-Wiśniewska Anna , Rodzki Michał , Krasińska Aleksandra , Perek Bartłomiej , Krasiński Zbigniew , Jemielity Marek
Published: December 2021

Background: Carotid artery disease accounts for 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated for predicting either the progression or the severity of the disease. The aim of this retrospective study was to compare hematologic indices among patients referred for surgical interventions due to severe carotid disease. Methods: In total, 135 patients (87 (64.4%) men and 48 (35.6%) women) with a mean age of 70 ± 8 years who underwent surgical carotid intervention were enrolled into the study. Results: A Mann–Whitney test for independent samples revealed significant differences in monocyte to lymphocyte ratio (MLR) and mean corpuscular hemoglobin concentration (MCHC) between patients with one and two (collateral) carotid diseases. The cut-off value for MLR was 0.3 (AUC = 0.654, p = 0.048, 70.0% sensitivity and 74.6% specificity) and for MHCH was 21.6. (AUC = 0.730, p < 0.001, 70.0% sensitivity and 77.2% specificity). A multivariable model of logistic regression revealed two significant parameters for collateral carotid stenosis disease including MLR > 0.3 (OR 6.19 with 95% CI 2.02–19.01, p = 0.001) and MCHC > 21.6 (OR 7.76, 95% CI 2.54–23.72, p < 0.001). Conclusions: MLR above 0.3 and MCHC above 21.6 have predictive values for colleterial carotid stenosis and may be used as easily accessible indicators for atherosclerosis severity.
The Effect of Intravenous Dexamethasone and Dexmedetomidine on Analgesia Duration of Supraclavicular Brachial Plexus Block: A Randomized, Four-Arm, Triple-Blinded, Placebo-Controlled Trial
Authors: Hong Boohwi , Oh Chahyun , Jo Yumin , Chung Woosuk , Park Eunhye , Park Hanmi , Yoon Seokhwa
Published: December 2021

Intravenous dexamethasone and dexmedetomidine, in conjunction with peripheral nerve blockade, have each been reported to prolong the duration of analgesia. This study tested whether combined use further prolongs analgesia duration after supraclavicular brachial plexus block (BPB) in patients undergoing orthopedic upper extremity surgery. One hundred twenty patients were randomized 1:1:1:1 to Control (saline bolus and midazolam infusion [0.05 mg/kg loading, 20 µg/kg/h thereafter]); DMED (saline bolus and dexmedetomidine infusion [1 μg/kg loading, 0.4 μg/kg/h thereafter]); DEXA (dexamethasone [10 mg] bolus and midazolam infusion); and DMED-DEXA (dexmedetomidine infusion and dexamethasone bolus) groups. The primary outcome was the duration of postoperative analgesia, defined as the time from the end of the BPB to the first dose of analgesia via a patient-controlled device. Median (interquartile range) times to first dose of analgesia in the Control, DMED, DEXA, and DMED-DEXA groups were 8.1 (6.2–11.6), 9.0 (8.1–11.3), 10.7 (8.1–20.5), and 13.2 (11.5–19.1) hours, respectively (p < 0.001). Pairwise comparisons showed significant prolongation of analgesia in the DEXA included groups compared with the non-DEXA included groups (DEXA vs. control, p = 0.045; DEXA vs. DMED, p = 0.045; DMED-DEXA vs. control, p < 0.001; DMED-DEXA vs. DMED, p < 0.001). A mixed effect model showed that dexamethasone was the only significant factor for the prolongation of analgesia (p < 0.001). Intravenous dexamethasone prolonged the analgesia duration of supraclavicular BPB after orthopedic upper extremity surgery. The concurrent use of mild to moderate sedation dose of intravenous dexmedetomidine in addition to intravenous dexamethasone showed no additional benefit to the prolongation of analgesia.
Simultaneous Analysis of Insurance Participation and Acreage Response from Subsidized Crop Insurance for Cotton
Authors: Sall Ibrahima , Tronstad Russell
Published: December 2021

US crop insurance is subsidized to encourage producers to participate and reduce their risk exposure. However, what has been the impact of these subsidies on insurance demand and crop acres planted? Using a simultaneous system of two equations, we quantify both insurance participation and acreage response to subsidized crop insurance for cotton-producing counties across the US at the national and regional levels. We also quantify the impact of both the realized rate of return and the expected subsidy per pound, plus the combined effects of expected yield and price while accounting for the adoption of Bacillus thuringiensis (Bt) technology and other factors. Results show that both the rate of return and the expected subsidy per unit of production have a statistically significant and positive effect on the percentage of arable acres planted. Furthermore, the marginal effect of expected price on insurance participation is much more significant for low- than high-yield counties. Results indicate that not all regions respond the same to subsidized crop insurance and that subsidies should be based on dollars per expected unit of production rather than expected production to be less distorting. Overall, US cotton acreage response is estimated to be inelastic (0.58) to insurance participation.
Green and Sustainable Life Insurance: A Bibliometric Review
Authors: Nobanee Haitham , Alqubaisi Ghaith Butti , Alhameli Abdullah , Alqubaisi Helal , Alhammadi Nouf , Almasahli Shahla Alsanah , Wazir Noora
Published: December 2021

Presently, there is a growing concern about implementing sustainable practices among businesses worldwide. Risk management is observed to contribute to the promotion of exercised business sustainability significantly. The study aims to examine published articles focusing on the role of risk management in promoting business sustainability practices and its advancement in the Cambridge online database to determine the current trend direction of this field. The paper’s conducted analysis is based on bibliographic co-word clustering analysis of the collected studies from the database. The research’s output disclosed four keyword clusters in the gathered articles’ titles and identified the most interested journals, countries, authors, subject areas, and organizations in the said topic and its popular research period. Based on the research output, recommendations regarding future research were provided, including expanding the list of databases for the data collection phase and utilizing the bibliographic coupling relations approach in the bibliometric analysis.
The Determinants of Investment Account Holders’ Disclosure in Islamic Banks: International Evidence
Authors: Saidani Raoudha , Taktak Neila Boulila , Hussainey Khaled
Published: December 2021

In this paper, we offer a novel contribution to Islamic accounting literature by examining the determinants of Investment Account Holder (IAH) disclosure in Islamic banks’ annual reports. Using data from Islamic banks around the world, our regression analysis shows that the level of IAH funds, the return on IAH funds, adoption of AAOIFI standards, liquidity level, bank size and ownership have a positive significant relationship with IAHs’ disclosure level. Our findings can be useful for IAHs, regulatory bodies and information users in general as they help them to understand IAH practices in Islamic banks and the main incentives of managers to disclose IAHs’ information. The present study offers an original contribution to the Islamic accounting literature as it is the first one—to the best of our knowledge—that investigates the relationship between the specificities of Islamic banks and the extent of IAH disclosure.
Creating Unbiased Machine Learning Models by Design
Authors: Breeden Joseph L. , Leonova Eugenia
Published: December 2021

Unintended bias against protected groups has become a key obstacle to the widespread adoption of machine learning methods. This work presents a modeling procedure that carefully builds models around protected class information in order to make sure that the final machine learning model is independent of protected class status, even in a nonlinear sense. This procedure works for any machine learning method. The procedure was tested on subprime credit card data combined with demographic data by zip code from the US Census. The census data serves as an imperfect proxy for borrower demographics but serves to illustrate the procedure.
Post-Acquisition Performance of Emerging Market Firms: A Multi-Dimensional Analysis of Acquisitions in India
Authors: Das Arindam
Published: December 2021

M&A performance is a multifaceted, compound construct with no overarching factor that captures all different dimensions. This paper examines the concept of acquisition performance and proposes a model that links firm-level factors and transaction parameters with firms’ short-term and long-term performance, extending to financial-, market- and innovation measures. Building on past empirical studies on the influence of various factors on M&A performance, a multi-dimensional structural equation model has been developed and it has been tested with a dataset on acquisitions in the Indian technology sector over a period of ten years. The results suggest that: (a) smaller acquirers with higher book value and leveraged firms demonstrate better long-term performance; (b) contrary to established understanding, short-term market returns are not influenced by deal parameters; (c) majority stake purchases show relatively lesser gains—suggesting the possible presence of post-acquisition integration issues and, (d) acquirers with high intangible assets continue to do well on innovation performance post-acquisition. By indicating situations and conditions under which an acquisition would potentially lead to a performance gain for the acquirer, these results provide significant insight to practitioners pursuing M&As for growth opportunities.
Project Management Maturity Models for Construction Firms
Authors: Machado Filipe , Duarte Nelson , Amaral António , Barros Teresa
Published: December 2021

This paper aims to identify and analyze project management maturity models in order to identify those best suited to be adopted in construction firms. To do so, models from papers available in academic repositories were analyzed. To be successful, the construction business deeply depends on projects outcomes; thus, the implementation of project management maturity models is important for this sector. A maturity model is a valuable technique to assess project management capabilities within a single part of an organization or to assess an organization as a whole. Its main purpose is to provide a means to create a more organized and predictable way for organizations to achieve their goals, increasing their chances of success regarding the outputs, outcomes, and benefits. In this paper, documentary research was performed to identify available project management maturity models and togather information about their performance. The information gathered was used to find elements to be compared with the identified models. Reviewing the literature, 39 project management maturity models were identified. The authors selected two PMMMs that were well fitted to assess the project management capabilities in construction firms: OPM3 and MMGP Prado.
Trust, Transparency and Welfare: Third-Sector Adult Social Care Delivery and the COVID-19 Pandemic in the UK
Authors: Chaney Paul , Sophocleous Christala
Published: December 2021

Since the move to quasi-federalism in the 1990s, different territorial welfare mixes on adult social care (ASC) have emerged in the four nations of the UK. This study explores policy actors’ views on their effectiveness in the pandemic with reference to the role of institutions, trust and transparency. The analysis is based on extensive secondary data analysis and primary interviews with key individuals involved in the delivery and regulation of ASC. The findings highlight how the pandemic exposed existing pathologies and the need for reform in all four systems. Notably, the analysis shows how the present market-based tendering systems for allocating ASC contracts undermine inter-personal and institutional trust and compromise care quality. The wider significance of this lies in showing the pivotal role of trust during the emergency and that post-pandemic welfare reform needs to embed trust-building measures to deliver effective care.
Using Keeper Questionnaires to Capture Zoo-Housed Tiger (Panthera tigris) Personality: Considerations for Animal Management
Authors: Bullock Natalie , James Charlotte , Williams Ellen
Published: December 2021

Individual personalities affect animal experiences of zoo environments, impact on an animal’s coping ability and have potential implications for welfare. Keeper assessments have been identified as a quick and reliable way of capturing data on personality in a range of species and have practical application in improving animal welfare on an individual level. Despite widespread recognition of the importance of animal personality within a zoo environment, there is a paucity of research into tiger personality and the potential impact of this on tiger experiences within zoos. This research investigated the personality of 34 tigers (19 Amur and 15 Sumatran) across 14 facilities in the UK using keeper ratings and identified changes keepers made in animal husbandry to support tiger welfare. Reliability across keepers (n = 49) was established for nine adjectives and a principal component analysis identified three personality components: ‘anxious’, ‘quiet’ and ‘sociable’. When subspecies were combined, there was no relationship between tiger scores on the personality components and age or sex of tigers (p > 0.05). Subspecies of tiger was not related to scores on the ‘quiet’ or ‘sociable’ components (p > 0.05). Sumatran tigers scored more highly than Amur tigers on the ‘anxious’ component (mean ± SD, Sumatran: 3.0 ± 1.7, Amur: 1.8 ± 0.6, p < 0.05). Analysis within subspecies found that male Amur tigers were more sociable than females (mean ± SD, males: 5.5 ± 0.707; females: 4.15 ± 0.55). Amur tiger age was also negatively correlated with scores on the sociable personality component (R = −0.742, p < 0.05). No significant differences were seen in Sumatran tigers. Keepers reported a number of changes to husbandry routines based on their perceptions of their tigers’ personality/needs. However, there was no significant relationship between these changes and tiger personality scores (p > 0.05). Despite significant evolutionary differences between Amur and Sumatran tigers, there are no subspecies specific guidelines for zoo tigers. This research has highlighted the potential for these two subspecies to display personality differences and we advocate further research into this area. Specifically, we highlight a need to validate the relationship between tiger personality, management protocols and behavioural and physiological metrics of welfare. This will enable a fuller understanding of the impact of personality on zoo tiger experiences and will enable identification of evidence-based best practice guidelines.
Integrated Planning: Towards a Mutually Inclusive Approach to Infrastructure Planning and Design
Authors: Schoulund Dario Hernan , Amura Carlos Alberto , Landman Karina
Published: December 2021

Increasingly independent fields of specialization, civil engineering, and urban design find themselves practicing in isolation on the same urban issues. The result surfaces on the relative qualities of public spaces: projects that are functionally successful but spatially poor, and vice versa This is critical in the global south, where infrastructure is prioritized, and politicized, as the key driver of change but often heedless of spatial consequences. The present study explores the dynamics of integration between logics arising from technical and spatial fields, and the planning processes under which such integration is feasible. An urban design/infrastructural project in Argentina, stalled for more than two decades under regulatory policies, was selected as a case study. An overview and background of the adopted planning/design methodologies are followed by a structural/spatial analysis, focusing on type, logistics, and construction on the one hand, and on indicators of successful public spaces on the other: access, uses, comfort and image. Aspects that a priori appeared as inevitable compromises found a common, but the critically logical ground in which urban and structural thinking complemented each other. More than a functional asset, infrastructure presents an opportunity to re-think the future of the built environment as a typology that could be conceived, designed and evaluated, on the same terms as successful public spaces.
Islandscapes and Sustainable Creative Tourism: A Conceptual Framework and Guidelines for Best Practices
Authors: Baixinho Alexandra , Santos Carlos , Couto Gualter , Albergaria Isabel Soares de , Silva Leonor Sampaio da , Medeiros Pilar Damião , Simas Rosa Maria Neves
Published: December 2021

As strategies for the development of creative tourism multiply in contexts ranging from global cities to small communities, the need for a clearer conceptual framework, capable of better differentiating existing approaches, has become more evident. Building upon existing knowledge on cultural and creative tourism, and on a prior review of the literature on creative tourism on islands, this paper proposes a typology of creative tourism initiatives, and after examining this new categorization, develops the concept of sustainable creative tourism. Through highlighting the need for creative tourism developers, policymakers, and practitioners to deepen their engagement with more holistic and integrated approaches oriented towards sustainable development in all its dimensions (economic, environmental, social, and cultural), the authors systematize a set of international principles and policy recommendations meant to promote sustainable creative tourism development strategies, duly adjusted to different places and realities, with an emphasis on vulnerable islandscapes.
Research on the Influencing Factors of Urban Ecological Carrying Capacity Based on a Multiscale Geographic Weighted Regression Model: Evidence from China
Authors: Liu Ke , Xie Xinyue , Zhou Qian
Published: December 2021

Based on the comprehensive evaluation method, a comprehensive urban ecological carrying capacity (UECC) evaluation system is established. It includes ecological support, ecological resilience, and ecological pressure. Multiscale geographically weighted regression (MGWR) was used to conduct a thorough examination of the spatial and temporal patterns, and the factors that influenced the UECC of 286 prefecture-level cities in China from 2010 to 2019. The results show that (1) China’s UECC index ranges from 0.0233 to 0.2811 in 2019, which is still at a low level. (2) The spatial distribution is relatively stable: high-value agglomerations of UECC are distributed primarily in the Yangtze River Delta and Pearl River Delta, while low-value agglomerations are primarily distributed in the regions in the Central Plains. (3) All influencing factors have a positive effect on the improvement of UECC and are heterogeneous in spatial distribution. Lastly, this paper gives corresponding suggestions, so that governments can formulate differentiated policies and effectively improve UECC.
The Impact of Mosaic Land Use and Land Cover on the Quality of River Waters (Case Study: Lubelskie Province, E Poland)
Authors: Dymek Dorota , Zgłobicki Wojciech , Baran-Zgłobicka Bogusława
Published: December 2021

Human activity with respect to land use and land cover can impact the quality of river water. Understanding the correlation between these two factors makes it possible to improve the management of space and mitigate negative human impacts on the environment. The present study encompassed 34 catchments in Lubelskie Province, a typically agricultural region in eastern Poland. Six main types of land use and land cover (LULC) and 15 indices of water quality have been analysed. An unequivocally negative impact of LULC on the river water parameters has not been found. For some indices, no correlations occur, while for others the statistical correlations are weak. One possible reason is the impact of other factors or the unique land use mosaic of the province having a significant impact on the circulation of pollutants in the landscape. It may be that the absence of clear correlations is the result of the relatively low anthropogenic pressure in the region.
A Validation Procedure for Ecological Corridor Locations
Authors: Lalechère Etienne , Bergès Laurent
Published: December 2021

Connectivity conservation analysis is based on a wide range of approaches designed to pinpoint key ecological corridors in order to maintain multispecies flows. However, the lack of validation procedures with accessible data prevents one from evaluating the accuracy of ecological corridor locations. We propose a new validation procedure to evaluate the accuracy of ecological corridor locations in landscape connectivity approaches. The ability of the procedure to properly rank the accuracy of different landscape connectivity approaches was illustrated in a study case. Maxent model and circuit theory were used to locate ecological corridors for forest bird species, following three approaches based on land cover, umbrella species and multispecies presence data. The validation procedure was used to compare the three approaches. Our validation procedure ranked the three approaches as expected, considering that accuracy in locating ecological corridors is related to the biological realism of calibration data. The corridors modelled were more accurate with species presence data (umbrella and multispecies approaches) compared to land cover proxy (habitat-based approach). These results confirm the quality of the validation procedure. Our validation procedure can be used to: (1) evaluate the accuracy of the location of ecological corridors; (2) select the best approach to locate ecological corridors, and (3) validate the underlying assumptions of landscape connectivity approaches (e.g., dispersal and matrix resistance values).
The Southern Moroccan Dialects and the Hilāli Category
Authors: Francisco Felipe Benjamin
Published: December 2021

The aim of this paper is to review the classification of the southern Moroccan dialects, advancing on the general description of these varieties. Recent descriptive studies provided us with new sources on the linguistic reality of southern Morocco, shedding light on the status of dialects commonly classified as Bedouin or ‘Hilāli’ within the Maghrebi context. To do so, the paper highlights conservative and innovative features which characterize the dialects of the area, focusing mainly—but not exclusively—on the updated data for two distant localities in southern Morocco: Essaouira and its rural outskirts—the Chiadma territory (Aquermoud and Sīdi Īsḥāq)—and Tafilalt, in south-eastern Morocco. The southern dialects have been situated in an intermediary zone between pre-Hilāli and Hilāli categories for a long time. Discussing their situation may contribute to understanding what distinguishes them as a dialectal group and also the validity of the ‘Hilāli’ category in the Moroccan context.
HPV and Recurrent Respiratory Papillomatosis: A Brief Review
Authors: Ouda Amr Mohamed , Elsabagh Ahmed Adel , Elmakaty Ibrahim Mohamed , Gupta Ishita , Vranic Semir , Al-Thawadi Hamda , Al Moustafa Ala-Eddin
Published: December 2021

Recurrent Respiratory Papillomatosis (RRP) is a rare but severe manifestation of human papillomavirus (HPV). As our knowledge about HPV infections has expanded, it has become possible to understand the course of RRP disease and unravel plausible efficient methods to manage the disease. However, the surge in reports on HPV has not been accompanied by a similar increase in research about RRP specifically. In this paper, we review the clinical manifestation and typical presentation of the illness. In addition, the pathogenesis and progression of the disease are described. On the other hand, we discuss the types of treatments currently available and future treatment strategies. The role of vaccination in both the prevention and treatment of RRP will also be reviewed. We believe this review is essential to update the general knowledge on RRP with the latest information available to date to enhance our understanding of RRP and its management.
COVID-19 and Artificial Intelligence: An Approach to Forecast the Severity of Diagnosis
Authors: Udriștoiu Anca Loredana , Ghenea Alice Elena , Udriștoiu Ștefan , Neaga Manuela , Zlatian Ovidiu Mircea , Vasile Corina Maria , Popescu Mihaela , Țieranu Eugen Nicolae , Salan Alex-Ioan , Turcu Adina Andreea , Nicolosu Dragos , Calina Daniela , Cioboata Ramona
Published: December 2021

(1) Background: The new SARS-COV-2 pandemic overwhelmed intensive care units, clinicians, and radiologists, so the development of methods to forecast the diagnosis’ severity became a necessity and a helpful tool. (2) Methods: In this paper, we proposed an artificial intelligence-based multimodal approach to forecast the future diagnosis’ severity of patients with laboratory-confirmed cases of SARS-CoV-2 infection. At hospital admission, we collected 46 clinical and biological variables with chest X-ray scans from 475 COVID-19 positively tested patients. An ensemble of machine learning algorithms (AI-Score) was developed to predict the future severity score as mild, moderate, and severe for COVID-19-infected patients. Additionally, a deep learning module (CXR-Score) was developed to automatically classify the chest X-ray images and integrate them into AI-Score. (3) Results: The AI-Score predicted the COVID-19 diagnosis’ severity on the testing/control dataset (95 patients) with an average accuracy of 98.59%, average specificity of 98.97%, and average sensitivity of 97.93%. The CXR-Score module graded the severity of chest X-ray images with an average accuracy of 99.08% on the testing/control dataset (95 chest X-ray images). (4) Conclusions: Our study demonstrated that the deep learning methods based on the integration of clinical and biological data with chest X-ray images accurately predicted the COVID-19 severity score of positive-tested patients.
CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities
Authors: Gao San-Hui , Liu Sheng-Zhi , Wang Gui-Zhen , Zhou Guang-Biao
Published: December 2021

The development of cancer is a multistep and complex process involving interactions between tumor cells and the tumor microenvironment (TME). C-X-C chemokine ligand 13 (CXCL13) and its receptor, CXCR5, make crucial contributions to this process by triggering intracellular signaling cascades in malignant cells and modulating the sophisticated TME in an autocrine or paracrine fashion. The CXCL13/CXCR5 axis has a dominant role in B cell recruitment and tertiary lymphoid structure formation, which activate immune responses against some tumors. In most cancer types, the CXCL13/CXCR5 axis mediates pro-neoplastic immune reactions by recruiting suppressive immune cells into tumor tissues. Tobacco smoke and haze (smohaze) and the carcinogen benzo(a)pyrene induce the secretion of CXCL13 by lung epithelial cells, which contributes to environmental lung carcinogenesis. Interestingly, the knockout of CXCL13 inhibits benzo(a)pyrene-induced lung cancer and azoxymethane/dextran sodium sulfate-induced colorectal cancer in mice. Thus, a better understanding of the context-dependent functions of the CXCL13/CXCR5 axis in tumor tissue and the TME is required to design an efficient immune-based therapy. In this review, we summarize the molecular events and TME alterations caused by CXCL13/CXCR5 and briefly discuss the potentials of agents targeting this axis in different malignant tumors.
A Systematic Review of Systematic Reviews on the Epidemiology, Evaluation, and Treatment of Plantar Fasciitis
Authors: Rhim Hye Chang , Kwon Jangwon , Park Jewel , Borg-Stein Joanne , Tenforde Adam S.
Published: December 2021

The number of systematic review and meta-analyses on plantar fasciitis is expanding. The purpose of this review was to provide a comprehensive summary of reviews on the topic pertaining to plantar fasciitis, identify any conflicting and inconsistent results, and propose future research direction. A qualitative review of all systematic reviews and meta-analyses related to plantar fasciitis up to February 2021 was performed using PubMed, Embase, Web of Science, and the Cochrane Database. A total of 1052 articles were initially identified and 96 met the inclusion criteria. Included articles were summarized and divided into the following topics: epidemiology, diagnosis, and treatment. While the majority of reviews had high level of heterogeneity and included a small number of studies, there was general consensus on certain topics, such as BMI as a risk factor for plantar fasciitis and extracorporeal shockwave therapy as an effective mode of therapy. A qualitative summary of systematic reviews and meta-analyses published on plantar fasciitis provides a single source of updated information for clinicians. Evidence on topics such as the epidemiology, exercise therapy, or cost-effectiveness of treatment options for plantar fasciitis are lacking and warrant future research.
Gene Expression Profiles in Two Razor Clam Populations: Discerning Drivers of Population Status
Authors: Coletti Heather A. , Bowen Lizabeth , Ballachey Brenda E. , Wilson Tammy L. , Waters Shannon , Booz Michael , Counihan Katrina L. , Hollmen Tuula E. , Pister Benjamin
Published: December 2021

With rapidly changing marine ecosystems, shifts in abundance and distribution are being documented for a variety of intertidal species. We examined two adjacent populations of Pacific razor clams (Siliqua patula) in lower Cook Inlet, Alaska. One population (east) supported a sport and personal use fishery, but this has been closed since 2015 due to declines in abundance, and the second population (west) continues to support commercial and sport fisheries. We used gene expression to investigate potential causes of the east side decline, comparing razor clam physiological responses between east and west Cook Inlet. The target gene profile used was developed for razor clam populations in Alaska based on physiological responses to environmental stressors. In this study, we identified no differences of gene expression between east and west populations, leading to two potential conclusions: (1) differences in factors capable of influencing physiology exist between the east and west and are sufficient to influence razor clam populations but are not detected by the genes in our panel, or (2) physiological processes do not account for the differences in abundance, and other factors such as predation or changes in habitat may be impacting the east Cook Inlet population.
Colorectal Cancer Screening: Impact of COVID-19 Pandemic and Possible Consequences
Authors: Harber Isabelle , Zeidan Dania , Aslam Muhammad N.
Published: December 2021

Colonoscopy procedure has been the key screening method to detect colorectal cancer (CRC). As a fatal disease, CRC needs early detection. The COVID-19 pandemic caused screening tests (colonoscopy) to be halted and delayed. As a result, there could be dire consequences such as later-stage or missed diagnosis or greater mortality. This report will analyze scientific literature pertaining to interrupted CRC screenings due to COVID-19 while drawing historical parallels from the 1918 flu pandemic. We conducted literature searches in the PubMed database as well as in Google Scholar. One of the main lessons learned from the 1918 flu pandemic was to employ social distancing to stop the spread of the virus. So, the global response at the start and peak of the COVID-19 pandemic was decreased hospital visits for any non-emergency cases. That led to a halt and delays in cancer (including CRC) screenings. The Medical community predicted this lag will cause more CRC cases and deaths in the future. However, reorganizing and changing screening method strategies were helpful during the ongoing pandemic. In conclusion, COVID-19 greatly affected CRC screening, including how we view the future of CRC screening. We can learn from this prospect to better prepare for future pandemics or other public health crises.
SMCKAT, a Sequential Multi-Dimensional CNV Kernel-Based Association Test
Authors: Maus Esfahani Nastaran , Catchpoole Daniel , Kennedy Paul J.
Published: December 2021

Copy number variants (CNVs) are the most common form of structural genetic variation, reflecting the gain or loss of DNA segments compared with a reference genome. Studies have identified CNV association with different diseases. However, the association between the sequential order of CNVs and disease-related traits has not been studied, to our knowledge, and it is still unclear that CNVs function individually or whether they work in coordination with other CNVs to manifest a disease or trait. Consequently, we propose the first such method to test the association between the sequential order of CNVs and diseases. Our sequential multi-dimensional CNV kernel-based association test (SMCKAT) consists of three parts: (1) a single CNV group kernel measuring the similarity between two groups of CNVs; (2) a whole genome group kernel that aggregates several single group kernels to summarize the similarity between CNV groups in a single chromosome or the whole genome; and (3) an association test between the CNV sequential order and disease-related traits using a random effect model. We evaluate SMCKAT on CNV data sets exhibiting rare or common CNVs, demonstrating that it can detect specific biologically relevant chromosomal regions supported by the biomedical literature. We compare the performance of SMCKAT with MCKAT, a multi-dimensional kernel association test. Based on the results, SMCKAT can detect more specific chromosomal regions compared with MCKAT that not only have CNV characteristics, but the CNV order on them are significantly associated with the disease-related trait.
Bee Venom, Honey, and Royal Jelly in the Treatment of Bacterial Infections of the Oral Cavity: A Review
Authors: Otręba Michał , Marek Łukasz , Tyczyńska Natalia , Stojko Jerzy , Rzepecka-Stojko Anna
Published: December 2021

Oral diseases affect a very large number of people, and the applied pharmacological methods of treatment and/or prevention have serious side effects. Therefore, it is necessary to search for new, safer methods of treatment. Natural bee products, such as honey, royal jelly, and bee venom, can be a promising alternative in the treatment of oral cavity bacterial infections. Thus, we performed an extensive literature search to find and summarize all articles about the antibacterial activity of honey, royal jelly, and bee venom. Our analysis showed that these bee products have strong activity against the bacterial strains causing caries, periodontitis, gingivitis, pharyngitis, recurrent aphthous ulcers, supragingival, and subgingival plaque. An analysis of average MIC values showed that honey and royal jelly have the highest antimicrobial activity against Porphyromonas gingivalis and Fusobacterium nucleatum. In turn, bee venom has an antibacterial effect against Streptococcus mutans. Streptococcus sobrinus and Streptoccus pyogenes were the most resistant species to different types of honey, and royal jelly, respectively. Moreover, these products are safer in comparison to the chemical compounds used in the treatment of oral cavity bacterial infections. Since the antimicrobial activity of bee products depends on their chemical composition, more research is needed to standardize the composition of these compounds before they could be used in the treatment of oral cavity bacterial infections.
Assessment of Collaboration-Based and Non-Collaboration-Based Logistics Risks with Plithogenic SWARA Method
Authors: Ulutaş Alptekin , Meidute-Kavaliauskiene Ieva , Topal Ayse , Demir Ezgi
Published: December 2021

Background: Uncertainty is the major source of hazards, and it is present in a wide range of business activities. Due to the high level of unpredictability in logistics operations, the logistics sector has traditionally operated in a high-risk environment. These risks have become considerably more complicated as the corporate environment has changed in recent years, such through globalization, environmental concerns, and changes in demand. As a result, in order for a logistics firm to thrive, it is necessary to evaluate and assess the risks associated with logistics. Methods: The Plithogenic Stepwise Weight Assessment Ratio Analysis (SWARA) has been used in this study to assess the logistics risks. The logistics risk considered in this study are transportation-related risks, purchasing-related risks, inventory-related risks, information-related risks, packaging-related risks, operational-related risks, geographical location-related risks, natural disaster-related risks, and organization-related risks. Results: The most significant logistics risks are found to be Inventory-Related Risks, while the least significant are Geographical Location-Related Risks. When compared to the standard SWARA approach, the Plithogenic SWARA method may be employed in group decision-making issues without losing information. Conclusions: The proposed technique will help logistics professionals make informed decisions and manage and analyze risks more efficiently. This study will also contribute to the literature as it is the first time that logistical risks have been addressed by utilizing the Plithogenic SWARA technique.
CF3-Bis-TEMPO-Vis: New Visible Light Active Bis-Benzimidazolequinone Alkoxyamine
Authors: Kielty Patrick , Farràs Pau , Smith Dennis A. , Aldabbagh Fawaz
Published: December 2021

Alkoxyamines of TEMPO usually dissociate thermally at >100 °C; however, room temperature homolysis, activated by visible light, occurs with benzimidazolequinone derivatives. 1,1’-Dimethyl-2,2’-bis{[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]methyl}-6-(trifluoromethyl)-1H,1’H-[5,5’-bibenzimidazole]-4,4’,7,7’-tetrone (CF3-Bis-TEMPO-Vis) is prepared in a 59% yield through NBS/H2SO4 oxidative demethylations of the dimethoxybenzimidazole-benzimidazolequinone precursor with aqueous work up. The alternative basic work up in air gave the epoxide derivative of CF3-Bis-TEMPO-Vis. Unlike the latter CF3-epoxide, both alkoxyamine residues are labile under green light (470–600 nm), and the rate of TEMPO release is three times slower than Bis-TEMPO-Vis.
4,4’-(Pyridin-4-ylmethylene)dibenzonitrile
Authors: Lancaster Ben M. J. , Nicholls Alexander J. , Baxendale Ian R.
Published: December 2021

This communication describes an unprecedented substitution cascade, in which 4-methylpyridine, following deprotonation with LDA, twice acts as a carbon nucleophile in an unusual SNAr process, to form a novel triarylmethane structure. A proposed mechanism for this sequence is presented that is supported by single crystal X-ray analysis of the resulting product. We believe this unique transformation is of note as it highlights a neat and efficient entry as a single step to complex triarylmethane architectures containing both substituted phenyl and pyridyl aromatics.
Multivariate Assessment of Procedures for Molecularly Imprinted Polymer Synthesis for Pesticides Determination in Environmental and Agricultural Samples
Authors: Marć Mariusz , Bystrzanowska Marta , Pokajewicz Katarzyna , Tobiszewski Marek
Published: December 2021

In the case of quantitative and qualitative analysis of pesticides in environmental and food samples, it is required to perform a sample pre-treatment process. It allows to minimalize the impact of interferences on the final results, as well as increase the recovery rate. Nowadays, apart from routinely employed sample preparation techniques such as solid-phase extraction (SPE) or solid-phase microextraction (SPME), the application of molecularly imprinted polymers (MIPs) is gaining greater popularity. It is mainly related to their physicochemical properties, sorption capacity and selectivity, thermo-mechanical resistance, as well as a wide range of polymerization techniques allowing to obtain the desired type of sorption materials, adequate to a specific type of pesticide. This paper targets to summarize the most popular and innovative strategies since 2010, associated with the MIPs synthesis and analytical procedures for pesticides determination in environmental and food samples. Application of multi-criteria decision analysis (MCDA) allows for visualization of the most beneficial analytical procedures in case of changing the priority of each step of analysis (MIPs synthesis, sample preparation process—pesticides extraction, chromatographic analysis) bearing in mind metrological and environmental issues.
Numerical Simulations of Laser-Induced Shock Experiments on Graphite
Authors: Morena Alberto , Peroni Lorenzo
Published: December 2021

The development of particle accelerators with ever increasing energies is raising the standards of the structures which could interact with the particle beams. These structures could be subjected to strong shockwaves in accidental scenarios. In order to test materials in such conditions, one of the most promising techniques is the impact with high-power lasers. In view of the setting up of future experimental campaigns within the Petawatt High-Energy Laser for Heavy Ion Experiments (PHELIX), the present work aims at the development of a numerical approach for the simulation of graphite impacted by laser beams. In particular, the focus is on the spallation damage caused by shockwave reflection: a sufficiently intense laser beam could ablate the matter until plasma conditions, hence producing a shockwave which could travel inside the material and reach a free surface. A numerical model to properly describe the spall fragmentation of graphite has been calibrated on the basis of literature-available experimental data. The numerical approach is a ‘two-step’ procedure: the first step is the definition of the laser–matter interaction and the second one concerns the description of the shockwave evolution into matter. The simulations satisfactorily reproduce the dynamic response of graphite impacted by two different laser sources with various intensities, despite the difficulties of characterising a phenomenon which is extremely fast and chaotic.
Effect of Low-Level Cyclic Loading on Bond Behavior of a Steel Bar in Concrete with Pre-Existing Damage
Authors: Yi Chongku , Lee Jeeho , Hong Kee-Jeung
Published: December 2021

Understanding the bond behavior of steel rebar in concrete is important in order to determine the performance of a reinforced concrete structure. Although numerous studies have been carried out by many researchers to develop a robust model for numerical analysis, no consensus has been reached as the bond behavior depends on hysteresis. In this study, the bond behavior of a steel bar in concrete with pre-existing damage is investigated under low-level cyclic loading. Based on the experimental bond stress and slip curve, a numerical model for finite element analysis to simulate the effect of low-level cyclic loading is proposed. The results from the numerical analysis show good agreement with the experimental data, including accumulated damage on stiffness and strength throughout entire load cycles.
Diamond for Electronics: Materials, Processing and Devices
Authors: Araujo Daniel , Suzuki Mariko , Lloret Fernando , Alba Gonzalo , Villar Pilar
Published: December 2021

Progress in power electronic devices is currently accepted through the use of wide bandgap materials (WBG). Among them, diamond is the material with the most promising characteristics in terms of breakdown voltage, on-resistance, thermal conductance, or carrier mobility. However, it is also the one with the greatest difficulties in carrying out the device technology as a result of its very high mechanical hardness and smaller size of substrates. As a result, diamond is still not considered a reference material for power electronic devices despite its superior Baliga’s figure of merit with respect to other WBG materials. This review paper will give a brief overview of some scientific and technological aspects related to the current state of the main diamond technology aspects. It will report the recent key issues related to crystal growth, characterization techniques, and, in particular, the importance of surface states aspects, fabrication processes, and device fabrication. Finally, the advantages and disadvantages of diamond devices with respect to other WBG materials are also discussed.
Using In Situ Measurements to Experimentally Characterize TiO2 Nanoparticle Synthesis in a Turbulent Isopropyl Alcohol Flame
Authors: Franzelli Benedetta , Scouflaire Philippe , Darabiha Nasser
Published: December 2021

The objective of the present work is to show the potential of in situ measurements for the investigation of nanoparticles production in turbulent spray flames. This is achieved by considering multiple diagnostics to characterize the liquid break-up, the reactive flow and the particles production in a spray burner for TiO2 nanoparticle synthesis. The considered liquid fuel is a solution of isopropyl alcohol and titanium tetraisopropoxide (TTIP) precursor. Measurements show that shadowgraphy can be used to simultaneously localize spray and nanoparticles, light scattering allows to characterize the TiO2 nanoparticles distribution in the flame central plane, and spontaneous CH* and OH* chemiluminescences, as well as global light emission results, can be used to visualize the reactive flow patterns that may differ with and without injection of TTIP. Concerning the liquid, it is observed that it is localized in a small region close to the injector nozzle where it is dispersed by the oxygen flow resulting in droplets. The liquid droplets rapidly evaporate and TTIP is quasi-immediately converted to TiO2 nanoparticles. Finally, results show high interactions between nanoparticles and the turbulent eddies.
Confirmation of Calcium Phosphate Cement Biodegradation after Jawbone Augmentation around Dental Implants Using Three-Dimensional Visualization and Segmentation Software
Authors: Alkhasawnah Qusai , Elmas Sera , Sohrabi Keywan , Attia Sameh , Heinemann Sascha , El Khassawna Thaqif , Heiss Christian
Published: December 2021

The use of autologous bone graft for oral rehabilitation of bone atrophy is considered the gold standard. However, the available grafts do not allow a fast loading of dental implants, as they require a long healing time before full functionality. Innovative bioactive materials provide an easy-to-use solution to this problem. The current study shows the feasibility of calcium phosphate cement paste (Paste-CPC) in the sinus. Long implants were placed simultaneously with the cement paste, and provisional prosthetics were also mounted in the same sessions. Final prosthetics and the full loading took place within the same week. Furthermore, the study shows for the first time the possibility to monitor not only healing progression using Cone Beam Computer tomography (CBCT) but also material retention, over two years, on a case study example. The segmented images showed a 30% reduction of the cement size and an increased mineralized tissue in the sinus. Mechanical testing was performed qualitatively using reverse torque after insertion and cement solidification to indicate clinical feasibility. Both functional and esthetic satisfaction remain unchanged after one year. This flowable paste encourages the augmentation procedure with less invasive measure through socket of removed implants. However, this limitation can be addressed in future studies.