bluuebunny/crossref_metadata_2025 huggingface dataset:
Holistic Approach for Creating Environmentally Friendly Campus
Authors: Andoko Andrey , Prastomo Niki
Published: July 2021

To achieve an environmentally friendly campus, UMN operates gas engine generator with co-generation system. Waste heat from generator powers absorption chiller for air conditioning. UMN benefits clean energy sources, reduced pollution, and energy saving. The next phases rely on energy consumption reduction by applying passive design. Two towers were designed with double-skin facade. The perforated aluminum panel reduces solar heat gain on the building wall while still allows sunlight into the room for natural lighting. Lower room temperature will reduce cooling load, which will save energy. Combined with energyefficient appliances and natural air ventilation for corridors and open space, this concept saves more than half of energy consumption. Both towers were awarded the first and second winners of ASEAN Energy Award in 2014 and 2019. Various trees have been planted and produce oxygen to supply fresh air to create comfortable studying environment without air conditioning. To reduce carbon footprint, UMN provides shuttle bus and bike-sharing service. A holistic approach is implemented by recycling and conserving water with sewage water treatment and infiltration wells surrounding the campus. As part of the sustainability program, UMN has also utilized solar energy.
O filmowości literatury: korespondencje, powinowactwa, paralele (na przykładzie polskiego międzywojnia)
Authors: Otto Wojciech
Published: July 2021

Podstawą przeprowadzonej refleksji jest świadomość istnienia wyraźnych korespondencji, powinowactw i paraleli pomiędzy literaturą a filmem. Dokonane ustalenia teoretyczne z wprowadzoną egzemplifikacją umożliwiają precyzyjną identyfikację tzw. punktów stycznych pomiędzy sztuką słowa a sztuką ekranu oraz rozpoznanie charakteru owych interakcji. Związki między filmem a literaturą mają dwutorowy, czyli paralelny charakter, a ich wzajemne relacje są różnorodne i wielopłaszczyznowe. Filmowość literatury może być rozpatrywana jako nawiązania pośrednie (wspólnota i homologia struktur) i bezpośrednie (filmowość właściwa) do filmu. Podczas analizy strukturalnej poszczególnych dzieł literackich należy uwzględnić również perspektywę socjokulturową, zawężoną do określonej formacji społeczno-kulturowej, w tym przypadku ograniczonej cezurami roku 1918 i 1939. Inspiracje literatury sztuką filmową można rozpatrywać na płaszczyźnie fabularnej, narracyjnej i genologicznej.
Multi beam microprocessing for printing and embossing applications with high power ultrashort pulsed lasers
Authors: Bruening Stephan , Gillner Arnold , Du Keming
Published: July 2021

Micro structuring of surfaces is of great interest for various applications, e.g. for the tooling industry, the printing industry and for consumer goods. In suitable mass production applications, such as injection molding or roll-to-roll processing for various markets, the final product could be equipped with new properties, such as hydrophilic behavior, adjustable gloss level, soft-touch behavior, light management properties etc. To generate functionalities at reasonable cost, embossing dies can be augmented with additional micro/nano-scale structure using laser ablation technologies. Despite the availability of ultrashort pulsed (USP) high power lasers (up to several hundred watts), it is still a challenge to structure large areas, as required on embossing rolls, in an acceptable processing time for industrial production. In terms of industrial implementation, direct digital transfer is a limiting factor for ultrahigh resolution. Shorter machining times by further increasing spot or workpiece motion are limited. Enlarging the ablation diameter, and thus the tool diameter, delivers a higher ablation rate with the comparable ablation quality, but entails a reduction in resolution. While maintaining the achieved state-of-the-art performance, upscaling of single modulated lasers provides a less demanding way to increase productivity. In the processing of steel surfaces, an increase in material removal can also be achieved by using pulse burst. In this work, the parallel process of single modulated multi laser sources is compared with a laser source split by diffractive optical elements (DOE) for applications in a cylinder micro patterning system. A newly developed highly compact ps laser with repetition rates up to 8 MHz and an average power of 300 or 500 W was divided into 8 or 16 parallel beamlets by a DOE. The ablation rate of each approach was investigated by typical microstructures on copper surfaces. At surface speeds of 10 m/s and a resolution of 5080 dpi, an ablation rate of up to 27 mm³/min was achieved. Different functional surface geometries were realized on an embossing roll as master, which is used for replication of the structures in roll-to-roll processes. Functional structures, such as friction reduction, improved soft touch or light guiding elements on large surfaces are demonstrated.
Diversity in Science at the Global Women’s Breakfast Network
Authors: Garson Mary J. , McConnell Laura L. , Soby Lynn M.
Published: July 2021

In a year marked by unprecedented challenges, IUPAC hosted the largest ever Global Women’s Breakfast (GWB2021) on 9 February 2021, bringing together more than 20,000 people around the world to celebrate the achievements of women scientists, to strengthen and expand professional networks, to inspire the next generations, and to challenge the status quo with respect to equality for women scientists in the workplace.
Parametric numerical study and optimization of mass transfer and bubble size distribution in a gas-liquid stirred tank bioreactor equipped with Rushton turbine using computational fluid dynamics
Authors: Salehi Sanaz , Heydarinasab Amir , Shariati Farshid Pajoum , Nakhjiri Ali Taghvaie , Abdollahi Kourosh
Published: July 2021

Designing and optimizing a bioreactor can be an especially challenging process. Computational modelling is an effective tool to investigate the effects of various operating parameters on bioreactor performance and identify the optimum ones. In this work, a computational fluid dynamics-population balance model (CFD-PBM) was developed to elucidate the effect of different geometrical and operating parameters on the hydrodynamics and mass transfer coefficient of a batch stirred tank bioreactor. The validated model was projected to predict the effect of different parameters including the gas flow rate, the impeller off-bottom clearance, the number of agitator blades, and rotational speed of the impeller on the velocity profiles, air volume fraction, bubble size distribution, and the local gas mass transfer coefficient (K

l

a) in the bioreactor. Air bubble breakup and coalescence phenomena were considered in all simulations. Factorial experimental design approach was employed to statistically investigate the impacts of the aforementioned operating and geometrical parameters on K

l

a and bubble size distribution in the bioreactor in order to determine the most significant parameters. This can give an essential insight into the most impactful factors when it comes to designing and scaling up a bioreactor.
The sono-photocatalytic performance of a novel water based Ti+4 coated Al(OH)3-MWCNT’s hybrid nanofluid for dye fragmentation
Authors: Malika Manjakuppam , Sonawane Shriram S.
Published: July 2021

The present study investigates the efficiency of a novel 3D artificially illuminated sono-photocatalytic reactor filled with the suspension of Ti+4 coated Al(OH)3-MWCNT's hybrid nanofluid in removing toxic fragments from the industrial wastewater. Within 40 min of reaction time, the synergistic effect of sonication induced photocatalysis achieved 99 percent dye degradation. Using response surface methodology (RSM-CCD) and artificial neural network (ANN) methods, the behaviour of the process in terms of reactor independent variables on dye removal was investigated and optimised. Both approaches proved to have a very good performance in modelling of the process and from RSM model, the optimum experimental conditions were at 0.5 vol% nanofluid concentration, 60 °C nanofluid temperature, and 60 min reaction time. Besides that, a quadratic polynomial equation (R
2 = 0.984) well describes the equilibrium data. Furthermore, the study of variance (ANOVA) approach revealed that the input parameters and their interactions had a substantial impact on the response variable. With an R
2 value of 0.999, the engineered multilayer perceptron ANN successfully validated the experimental findings. Given the significant improvement in photocatalytic degradation of industrial wastewater, the current research can be viewed as a promising pre-treatment step for producing low toxic intermediates.
Modeling the interaction of birds and small fish in a coastal lagoon
Authors: Kant Shashi
Published: July 2021

Coastal lagoons are high value productive and important systems for different projects. For example, aquaculture, fisheries and tourism are few of them. The quality of coastal waters in the ecosystems of lagoons can be greatly influenced by the growth of unwanted elements, e.g., excessive fisheries, tourism, etc. In this paper, a mathematical model is proposed and analysed to study the general and simplified form of an ecosystem of Chilika Lake, India. Chilika Lake (19°28′N–19°54′N and 85°06′E–85°36′E) is the largest wintering ground for migrating water fowl found anywhere on the Indian sub-continent. These migratory birds utilize the Chilika Lake for feeding, resting and breeding. The interaction of birds and small fish in the Chilika Lake is considered to be Leslie–Gower Holling type II. Since big fish are being sourced as income for local fishermen and the population of big fish is highly variable, and hence birds and small fishes are mainly the two types of biomass considered for this study. It must be noted that, in this study, we have considered the case of Chilika lake theoretically only and no practical data is collected for this study, and the name of Chilika is used only for better ecological understanding. Therefore, this theoretical study maybe linked to any such ecosystem. Their interaction is found mathematically, a two-dimensional continuous-time dynamical system modeling a simple predator–prey food chain. The dynamical system is represented in the form of two nonlinear coupled ordinary differential equation (ODE) systems. The main mathematical results are given in terms of boundedness of solutions, existence of equilibria, local and global stability of the coexisting interior point. An ecosystem in Indian coastal lagoons may suffer immediate environmental perturbations, such as depressions, tropical cyclones, earthquakes, epidemics, etc. To model such situations, the ODE model is further extended to a stochastic model driven by L

e

́

$\check{d}{e}$

vy noise. The stochastic analysis includes the existence of the unique global solution, stability in mean, and extinction of the population. The proposed model is numerically simulated with the help of an assumed set of parameters for the possible pictorial behavior of the theoretical model. The proposed model may be used for planning purposes by using the data on meteorological and weather shocks such as heavy rainfall, heat-waves, cold-waves, depressions, tropical cyclones, earthquakes, etc. from India Meteorological Department (IMD).
Feasibility, face, and content validity of quantitative computed tomography in interstitial lung disease related to connective tissue diseases
Authors: Sambataro Gianluca , Sambataro Domenico , Orlandi Martina , Battisti Sofia , Cavagna Lorenzo , Sverzellati Nicola , Silva Mario , Palmucci Stefano , Colaci Michele , Malatino Lorenzo , Ariani Alarico
Published: July 2021

Objectives

Quantitative computed tomography (QCT) is a promising tool for objective assessment of interstitial lung disease (ILD) related to connective tissue diseases (CTD). However, its validity was never investigated. The aim of this study was to assess QCT feasibility, face, and content validity evaluation concerning CTD-ILD.

Methods

A rheumatologist and a chest radiologist conceived an online survey with nine statements: Two about general issue involving CTD-ILD, one for the face validity, three both for content validity and feasibility. Each statement had to be rated with a score from 0 to 100, respectively, (complete disagreement and agreement). We considered a statement supported by the experts if the median score was ≥75.0.

Results

A panel of 14 experts (11 from Europe, three from America) with a nine years median experience was enrolled. All the statements about feasibility, face and content validity were supported, except for QCT capability to recognize elementary lesions.

Conclusions

The panel of experts supported feasibility, face, and content validity of QCT assessment concerning CTD-ILD. This may stimulate a greater use in clinical practice and further studies to confirm its discriminative properties and its construct validity.
Arcuate and Preoptic Kisspeptin Neurons Exhibit Differential Projections to Hypothalamic Nuclei and Exert Opposite Postsynaptic Effects on Hypothalamic Paraventricular and Dorsomedial Nuclei in the Female Mouse
Authors: Stincic Todd L. , Qiu Jian , Connors Ashley M. , Kelly Martin J. , Rønnekleiv Oline K.
Published: July 2021

Kisspeptin (Kiss1) neurons provide indispensable excitatory input to gonadotropin-releasing hormone (GnRH) neurons, which is important for the coordinated release of gonadotropins, estrous cyclicity and ovulation. However, Kiss1 neurons also send projections to many other brain regions within and outside the hypothalamus. Two different populations of Kiss1 neurons, one in the arcuate nucleus (Kiss1ARH) and another in the anteroventral periventricular nucleus (AVPV) and periventricular nucleus (PeN; Kiss1AVPV/PeN) of the hypothalamus are differentially regulated by ovarian steroids, and are believed to form direct contacts with GnRH neurons as well as other neurons. To investigate the projection fields from Kiss1AVPV/PeNand Kiss1ARHneurons in female mice, we used anterograde projection analysis, and channelrhodopsin-assisted circuit mapping (CRACM) to explore their functional input to select target neurons within the paraventricular (PVH) and dorsomedial (DMH) hypothalamus, key preautonomic nuclei. Cre-dependent viral (AAV1-DIO-ChR2 mCherry) vectors were injected into the brain to label the two Kiss1 neuronal populations. Immunocytochemistry (ICC) for mCherry and neuropeptides combined with confocal microscopy was used to determine the projection-fields of both Kiss1 neuronal groups. Whole-cell electrophysiology and optogenetics were used to elucidate the functional input to the PVH and DMH. Our analysis revealed many common but also several clearly separate projection fields between the two different populations of Kiss1 neurons. In addition, optogenetic stimulation of Kiss1 projections to PVH prodynorphin, Vglut2 and DMH CART-expressing neurons, revealed excitatory glutamatergic input from Kiss1ARHneurons and inhibitory GABAergic input from Kiss1AVPV/PeNneurons. Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.
Temporal Correlates to Monaural Edge Pitch in the Distribution of Interspike Interval Statistics in the Auditory Nerve
Authors: Li Yi-Hsuan , Joris Philip X.
Published: July 2021

Pitch is a perceptual attribute enabling perception of melody. There is no consensus regarding the fundamental nature of pitch and its underlying neural code. A stimulus which has received much interest in psychophysical and computational studies is noise with a sharp spectral edge. High-pass (HP) or low-pass (LP) noise gives rise to a pitch near the edge frequency (monaural edge pitch; MEP). The simplicity of this stimulus, combined with its spectral and autocorrelation properties, make it an interesting stimulus to examine spectral versus temporal cues that could underly its pitch. We recorded responses of single auditory nerve (AN) fibers in chinchilla to MEP-stimuli varying in edge frequency. Temporal cues were examined with shuffled autocorrelogram (SAC) analysis. Correspondence between the population’s dominant interspike interval and reported pitch estimates was poor. A fuller analysis of the population interspike interval distribution, which incorporates not only the dominant but all intervals, results in good matches with behavioral results, but not for the entire range of edge frequencies that generates pitch. Finally, we also examined temporal structure over a slower time scale, intermediate between average firing rate and interspike intervals, by studying the SAC envelope. We found that, in response to a given MEP stimulus, this feature also systematically varies with edge frequency, across fibers with different characteristic frequency (CF). Because neural mechanisms to extract envelope cues are well established, and because this cue is not limited by coding of stimulus fine-structure, this newly identified slower temporal cue is a more plausible basis for pitch than cues based on fine-structure.
Representing climate evolution in ensembles of GCM simulations for the Hudson Bay System
Authors: Braun Marco , Thiombiano Alida N. , Vieira Michael J. F. , Stadnyk Tricia A.
Published: July 2021

Climate impact studies often require a reduction of the ensembles of opportunity from the Coupled Model Intercomparison Project when the simulations are used to drive impact models. An impact model’s nature limits the number of feasible realizations based on complexity and computational requirements or capacities. For the purpose of driving a hydrological model and an ocean model in the BaySys research program, two hierarchical, differently sized simulation ensembles were produced to represent climate evolution for the region of the Hudson Bay Drainage Basin. We compare a 19-member ensemble to a 5-member subset to demonstrate comparability of the driving climate used to produce model results. Ten extreme climate indicators and their changes are compared for the full study region and seven sub regions, on an annual and seasonal basis and for two future climate horizons. Results indicate stronger warming in the North and for cold temperatures and an East-West gradient in precipitation with larger absolute increases to the East and South of the Hudson Bay. Generally, the smaller ensemble is sufficient to adequately reproduce the mean and spread in the indicators found for the larger ensemble. The analysis of extreme climate indicators ensures that the tails of the distribution of temperature and precipitation are addressed. We conclude that joint analysis at the interface of the hydrological and ocean model domains are not limited by the application of differently sized climate simulation ensembles as driving input for the two different modeling exercises of the BaySys project environmental studies, yet acknowledging that impact model output may be dependent on other factors.
Perioperative control of paroxysmal hypertension using esmolol with alpha-blockade in a child with a germline mutated paraganglioma
Authors: Babiker Amir , Al Hamdan Wejdan , Kinani Sondos , Kazzaz Yasser , Habeb Abdelhadi , Al Harbi Talal , Al Dubayee Mohammed , Al Namshan M , Attasi Abdul Aleem
Published: July 2021

The use of antihypertensive medications in patients with pheochromocytomas and paragangliomas (PCC/PG) is usually a challenge. We report a case of familial paraganglioma that was successfully treated by esmolol and other antihypertensive medications without associated perioperative complications. Our patient was an 11-year-old girl who presented with classic symptoms and signs of PCC/PG and a CT scan of the abdomen that showed a right-sided paravertebral mass. Her father was diagnosed with paraganglioma a few years ago. Prazosin had been started but she continued to experience uncontrolled paroxysms of blood pressure (BP). She was known to have asthma; hence, she developed serious bronchospasm with atenolol. She was, therefore, switched to esmolol that successfully controlled her BP in addition to prazosin and intermittent doses of hydralazine prior to laparoscopic surgery with no side effects of medications or postoperative complications. Esmolol could be a good alternative to routinely used beta-blockers in children with PCC/PG with labile hypertension and related symptoms in the pre and intra-operative periods. It is titrable, effective, and can be weaned rapidly helping to avoid postoperative complications. Further larger studies on the use of esmolol in children with PCC/PG are needed to confirm our observation.

Learning points

In addition to alpha-blockers, esmolol could be a good alternative for routinely used beta-blockers to control paroxysmal hypertension and tachycardia in the pre- and intra-operative periods.

Esmolol is titrable and an effective beta-blocker. It can be weaned rapidly helping to avoid postoperative complications in children with PCC/PG.

Children with PCC/PG and other comorbidity like asthma may particularly benefit from the use of esmolol due to no or less side effects on airway resistance and the advantage of rapid titration of the medication compared to other beta-blockers.
Biochemical transition during triphasic postpartum thyroiditis: confusion with central hypothyroidism
Authors: Oyibo Samson O , Green Olivia S , Laliwala Nabeel M , Sagi Satyanarayana V
Published: July 2021

Hypothyroidism occurring in the postpartum period can be due to pituitary or hypothalamic disease as in Sheehan’s syndrome and postpartum autoimmune hypophysitis or due to a primary thyroid disease as in postpartum thyroiditis. It is important that the correct diagnosis is ascertained because hypothalamic or pituitary disorders are often associated with other pituitary hormone deficiencies, especially life-threatening adrenal insufficiency or adrenal crisis. A combination of various symptoms and biochemical markers, especially serum thyroid-stimulating hormone levels dictate the initial diagnostic pathway. We present a case of a woman who presented with a 2-month history of tiredness and neck discomfort following delivery. A thyroid function test demonstrated results, which we initially interpreted as central hypothyroidism. Follow-up results indicated that this was in fact the transition period between the thyrotoxic phase and hypothyroid phases of postpartum thyroiditis. This case highlights the potential for diagnostic confusion between central hypothyroidism and postpartum thyroiditis.

Learning points

Postpartum thyroiditis affects one in twenty mothers within 12 months of delivery.

The majority of patients have transient thyrotoxicosis only, some have transient hypothyroidism only, and the rest has a triphasic pattern (thyrotoxic, hypothyroid then a euthyroid phase).

During the transition from the thyrotoxic phase to hypothyroid phase, when serum TSH is still suppressed, the biochemical results can resemble that of central hypothyroidism.

If central hypothyroidism is suspected, then urgent diagnostic investigations should be carried out along with the assessment of adrenal function.

There is a potential for diagnostic confusion between postpartum central hypothyroidism and postpartum thyroiditis; however, the obstetric history, clinical symptoms, and signs (headaches, breastfeeding, goitre, etc.) and serum adrenocorticotropic levels should help with the differential diagnosis.
An analysis of renewable energy consumption efficiency in terms of greenhouse gas production in selected European countries
Authors: Rozenský Ladislav , Hájek Miroslav , Vrba Zdeněk , Pokorný Richard , Hansen Justin Michael , Lípa Jan
Published: July 2021

The consumption of renewable energy sources results in the minimal production of greenhouse gases. However, the issue of environmentally efficient use of renewable energy sources remains a key concern. The primary aim of this article was to assess whether the energy production from renewable energy sources was environmentally efficient in four selected European countries: Germany, Austria, Poland, and the Czech Republic. In order to achieve the primary research goal, a regression analysis method was used for several variables. The results of the analysis suggested that with an increase in the consumption rate of renewable energy sources and biofuels equivalent to one thousand tons of oil, the volume of emissions from all sectors would increase by 0.0048 thousand tons (4.8 tons) on average. The system of emission allowances was rather environmentally inefficient at the lower allowance levels; in the monitored period of 2007 to 2016, the dependence of greenhouse gas production on the consumption of fossil fuels did not statistically manifest itself. Based on the analysis, the land use, land-use change, and forestry production activities do not contribute to increasing total greenhouse gas emissions.
Improving Care Management in Attention-Deficit/Hyperactivity Disorder: An RCT
Authors: Guevara James P. , Power Thomas J. , Bevans Katherine , Snitzer Lisa , Leavy Siobhan , Stewart Denise , Broomfield Caroline , Shah Salima , Grundmeier Robert , Michel Jeremy J. , Berkowitz Steven , Blum Nathan J. , Bryan Matthew , Griffis Heather , Fiks Alexander G.
Published: July 2021

OBJECTIVES

To compare the effectiveness of care management combined with a patient portal versus a portal alone for communication among children with attention-deficit/hyperactivity disorder (ADHD).

METHODS

Randomized controlled trial conducted at 11 primary care practices. Children aged 5 to 12 years old with ADHD were randomly assigned to care management + portal or portal alone. The portal included parent-reported treatment preferences and goals, medication side effects, and parent- and teacher-reported ADHD symptom scales. Care managers provided education to families; communicated quarterly with parents, teachers, and clinicians; and coordinated care. The main outcome, changes in the Vanderbilt Parent Rating Scale (VPRS) score as a measure of ADHD symptoms, was assessed using intention-to-treat analysis.

RESULTS

A total of 303 eligible children (69% male; 46% Black) were randomly assigned, and 273 (90%) completed the study. During the 9-month study, parents in the care management + portal arm communicated inconsistently with care managers (mean 2.2; range 0–6) but similarly used the portal (mean 2.3 vs 2.2) as parents in the portal alone arm. In multivariate models, VPRS scores decreased over time (Adjusted β = −.015; 95% confidence interval −0.023 to −0.07) in both groups, but there were no intervention-by-time effects (Adjusted β = .000; 95% confidence interval −0.011 to 0.012) between groups. Children who received ≥2 care management sessions had greater reductions in VPRS scores than those with fewer sessions.

CONCLUSIONS

Results did not provide evidence that care management combined with a patient portal was different from portal use alone among children with ADHD. Both groups demonstrated similar reductions in ADHD symptoms. Those families with greater care management engagement demonstrated greater reductions than those with less engagement.
Development of a molecular biological assay for the detection of markers related to decreased susceptibility to macrolides and lincomycin in Mycoplasma hyorhinis
Authors: Földi Dorottya , Kreizinger Zsuzsa , Bekő Katinka , Belecz Nikolett , Bányai Krisztián , Kiss Krisztián , Biksi Imre , Gyuranecz Miklós
Published: July 2021

The control of Mycoplasma hyorhinis infection relies mainly on antimicrobial therapy. However, the antibiotic susceptibility testing of the bacteria is usually not performed before applying the treatment, and thus therapeutic failures are not uncommon. In the case of M. hyorhinis, several antibiotic-resistance-related single nucleotide polymorphisms (SNPs) are known but assays for their detection have not been described yet. The aims of the present study were to investigate macrolide- and lincomycin-resistance-related SNPs in Hungarian M. hyorhinis isolates and to develop mismatch amplification mutation assays (MAMA) to detect the identified resistance markers. Minimal inhibitory concentrations (MIC) of different drugs and whole genome sequences of 37 M. hyorhinis isolates were used to find the resistance-related mutations. One MAMA assay was designed to detect the mutation of the 23S rRNA gene at nucleotide position 2058 (Escherichia coli numbering). For further evaluation, the assay was challenged with 17 additional isolates with available MIC data and 15 DNA samples from clinical specimens. The genotypes of the samples were in line with the MIC test results. The developed assay supports the practice of targeted antibiotic usage; hence it may indirectly reduce some bacterial resistance-related public health concerns.
Notes on Dineutus helleri Ochs, 1925, with new records for the Cyclops Mountains Whirligig Beetle, Dineutus h. stueberi Ochs, 1955 (Coleoptera, Gyrinidae)
Authors: Surbakti Suriani , Balke Michael , Hájek iří , Gustafson Grey
Published: July 2021

We review Dineutus helleri Ochs, 1925, a whirligig beetle species endemic to New Guinea’s north coast mountains. Its diagnostic characters are illustrated for easy species identification. We provide a summary and geographic interpretation of historical records, provide new records and, for the first time, habitat photographs for the subspecies D. h. stueberi Ochs, 1955, which is endemic to the Cyclops Mountains area. We also discuss the subspecies classification of this species.
Identification of c.199-10T>G mutation in SLC25A20 gene related to fatty acid oxidation disorders on a Vietnamese patient
Authors: Hoang Nguyen Huy , Thanh Duong Chi , Dung Vu Chi
Published: July 2021

Fatty acid oxidation disorders (FAODS) consist of rare diseases which affect the energy production of the mitochrondria by disrupting the β-oxidation of fatty acid, resulting in energy deficiency and toxic acumulation in the patient’s body. Typical clinical symtoms of FAODS include rhabdomyolysis, myoglobinuria, cardiomyopathy, hypoketotic hypoglycemia and liver dysfunction on the newborns and could lead to mortality in most of the cases. Mutations occur in different genes in the enzymatic pathway of the mitochrondria may cause diffirent types of FAODS.The objective of this study was to screen and identify genetic mutations associated with fatty acid oxidation disorders in Vietnamese patients through whole exome sequencing analysis. The result revealed a reported homozygous c.199-10T>G mutation in the position of 10 nucleotides before the exon 3 of the SLC25A20 gene. The SLC25A20 gene encodes the carnitine acylcarnitine translocase (CACT), which plays an important role in transporting acylcarnitine and carnitine in the mitochondria. Genetic mutations in this gene often lead to carnitine-acylcarnitine translocase deficiency (CACTD) - a rare form of FAODs. By in silico analysis, the c.199-10T>G mutation was predicted as a splite site mutation that could lead to exon skipping during the creation of mature mRNA. Genetic analysis of the patient’s family showed that both parents had the mutation c.199-10T>G in heterozygous form. This result suggests that every mutant allele in the patient is inherited from parents. Our finding not only improved our understanding of the c.199-10T>G mutation in SLC25A20 gene of our patient but also provides important information for future research, diagnosis and genetic counseling of FAOS in Vietnamese patients.
Improved in vitro rooting and acclimatization of “Violetta” Artichoke and “Green Globe” Artichoke
Authors: Khai Hoang Dac , Mai Nguyen Thi Nhu , Anh Hoang Le Lan , Nguyet Nguyen Nhu Minh , Long Ho Viet , Luan Vu Quoc , Hien Vu Thi , Tung Hoang Thanh , Cuong Do Manh , Lich Tran Van , Nhung Tran Thi , Ha Chu Duc , Thuc Le Van , Nhut Duong Tan
Published: July 2021

Artichoke (Cynara scolymus L.), a medicinal plant with high economic value, contains high levels of phenolic compounds; especially cynarine, which plays an important role in preventing cancer, cardiovascular disease, osteoporosis, diabetes and neurodegeneration, etc. Currently, Artichoke micropropagation has achieved some success; however, the rooting efficiency and plantlet quality are still limited. In this study, improving the quality of Artichoke plantlet related to the shoot quality and suitable substrates in in vitro rooting stage was studied on “Violetta” Artichoke (VA) and “Green Globe” Artichoke (GA). The results showed that shoots (1.5 cm) cultured on MS medium supplemented 0.5 mg/L KIN were most suitable to shoot multiplication of VA with the number of shoots/explant (3.67 shoots), number of shoots ≥ 2 cm (3 shoots); while, 1.0 mg/L BA was suitable to shoot multiplication of GA (5.33 shoots; 5.00 shoots; respectively) after 4 weeks of culture. Besides, the in vitro rooting was improved using 8 g/L commercial agar for VA; meanwwhile, 3 g/L gelrite for GA. In addition, the nylon bag culture system (120 mm × 250 mm) has potential in plantlet production (15 plants/bag) and can be applied for large scale micropropagation. In addition, VA and GA plantlets derived from in vitro culture gave the good acclimatization, growth and development after 8, 12 and 20 weeks cultivating at the green house conditions.
Proteogenomics and its applications in biology and precision medicine
Authors: Van Chi Phan , Thi Bich Thao Le
Published: July 2021

In this review, we briefly discuss proteogenomics, the integration of proteomics with genomics and transcriptomics, whereby the underlying technologies are next-generation sequencing (NGS) and mass spectrometry (MS) with processing the resulting data, an emerging field that promises to accelerate fundamental research related to transcription and translation, as well as its applicability. By combining genomic and proteomic information, scientists are achieving new results due to a more complete and unified understanding of complex molecular biological processes. Part of this review introduces some of the results of using proteogenomics in solving problems such as annotation, gene/genome re-annotation, including editing of open reading frames (ORFs), or improving a process to detect new genes in a number of different organisms, including humans. In particular, the paper also discusses the potential of proteogenomics through research achievements on human genome/proteome in precision medicine, especially in projects on phylogenetic and diagnostic research. and cancer treatment. The challenges and future of proteogenomics are also discussed and documented.
Isolation, sequencing and expression of the gene encoding acetoacetyl-coa thiolase from Panax vietnamensis Ha et Grushv.
Authors: Trinh Vu Thi , Han Ly Luu , Hue Huynh Thi Thu , Thu Hien Le Thi
Published: July 2021

Panax vietnamensis Ha et Grushv., naturally distributed in Ngoc Linh Mountain, is an endemic Panax species of Vietnam. For centuries, P. vietnamensis has been used in traditional folk medicine to treat many serious diseases or enhance physical strength. Ginsenosides are responsible for most of the medicinal effects of the Panax species. Acetoacetyl-CoA thiolase (AACT) is considered as an important enzyme involved in the biosynthesis of ginsenoside. In this study, a full-length cDNA of the gene encoding AACT protein (GeneBank accession number MZ272018) was obtained from P. vietnamensis using reverse transcription PCR. The gene open reading frame (1224 bp) encodes 408 amino acids. This cDNA sequence is 99.08% similar to the cDNA sequence of Panax notoginseng (KJ804173.1). The functional analysis of its protein by InterPro showed that the structure of AACT monomer consists of three domains, including thiolase-like domain (17-285), N-terminal (18-276), and C-terminal (286-406). Although there were some differences in the nucleotide sequence of the AACT cDNA gene between P. vietnamensis and the reference species, all important domains and sites related to the thiolase activity were observed. Phylogenetic analysis using AACT cDNA gene sequence revealed a close relationship of P. vietnamensis with P. notoginseng and Trachyspemum ammi. The quantitative real-time PCR results indicated the expression of AACT gene of P. vietnamensis depended on types of tissue and plant developmental stages (1, 4, 6 and 11 years old). The gene was expressed at higher levels in roots than in leaves and the highest expression of AACT gene was detected in the 11-year-old roots. The results provided valuable information for further studies on the biosynthesis of ginsenoside in P. vietnamensis in particular and Panax species in general.
Social control and nursing performance in defense of life in the COVID-19 pandemic
Authors: Martins Amanda de Lucas Xavier , Crisostomo Júnior Vicente José Leitão , David Helena Maria Scherlowski Leal
Published: July 2021

ABSTRACT Objective: to reflect on social control in health and the contributions that nursing can make to cope with the COVID-19 pandemic. Methods: this is a theoretical reflection, elaborated from discussions based on literature and the experience of authors’ performance in social control and in Primary Care. It is divided into two topics: the first, related to aspects of institutionalized social control; the second, related to the perspectives for nursing in this space. Results: limits and relevant aspects for nurses’ role in social control are presented, contributing to a perspective of praxis in health based on their ethical-political commitment and their technical competence in the coordination and management of care to face the pandemic. Final considerations: nurses’ role in social control favors the strengthening of the struggle for the right to life above profits, especially through popular participation in the community context in Primary Care.
The role of the radiologist in the assessment of thoracic changes after radiotherapy
Authors: Ando Sabrina de Mello , Fonseca Eduardo Kaiser Ururahy Nunes , Frassei Julliana dos Santos , Farias Lucas de Pádua Gomes de , Neves Yuri Costa Sarno , Chate Rodrigo Caruso , Sawamura Márcio Valente Yamada
Published: July 2021

Abstract Radiotherapy plays a central role in the palliative and curative treatment of neoplasms of the chest wall or intrathoracic structures. However, despite technical advances, radiotherapy can alter previously normal organs and tissues, those alterations presenting as various types of imaging findings. Post-radiation alterations must be promptly recognized by radiologists, in order to avoid confusion between complications of radiotherapy and the recurrence of a tumor. This pictorial essay aims to illustrate different thoracic changes after radiotherapy.
Prostatic artery embolization for giant prostatic hyperplasia: a single-center experience
Authors: Assis André Moreira de , Moreira Airton Mota , Carnevale Francisco Cesar , Lanz-Luces José Ramón
Published: July 2021

Abstract Objective: To describe the safety and efficacy of prostatic artery embolization (PAE) in patients with a markedly enlarged prostate. Materials and Methods: This was a retrospective study including 18 consecutive patients (mean age, 74 years) with benign prostatic hyperplasia, all with a prostate volume ≥ 200 cm3, who were enrolled to receive PAE for the treatment of moderate-to-severe lower urinary tract symptoms. Results: The PAE procedure was technically successful in 17 patients (94.4%). During follow-up, clinical failure (defined as an International Prostate Symptom Score [IPSS] ≥ 8) was observed in two (11.1%) of those 18 patients. At 3 months of follow-up, there was significant improvement over baseline in all relevant outcome measures: total IPSS (from 15.7 to 2.9); IPSS quality of life score (from 5.2 to 1.0); prostate specific antigen (from 11.4 to 1.82 ng/mL); peak urinary flow rate (from 7.45 to 18.6 mL/s); prostate volume (from 252.4 to 151.6 cm3); and post-void residual volume (from 143.7 to 28.3 mL)-p < 0.05 for all. Of the 18 patients, one (5.6%) presented detachment of prostate tissue and self-limited hematuria, which did not require specific treatment. Conclusion: In patients with a markedly enlarged prostate, PAE proved to be safe and effective, resulting in significant improvements in clinical, imaging, and urodynamic parameters.
Pancreas-kidney transplantation: what every radiologist should know
Authors: Minoda Alexandre Makoto , Ferreira Fernando dos Santos , Santos Karllos Diego Ribeiro , Leão Cristiano de Souza , Silva Eduardo Just da Costa e , Melo-Leite Andréa Farias de
Published: July 2021

Abstract Pancreas transplantation is a well-established treatment for patients with complicated diabetes mellitus and advanced renal failure. The most common procedure is simultaneous pancreas-kidney transplantation, in which the pancreas graft is positioned in the right pelvic region and the kidney graft is positioned in the left iliac fossa. Various imaging methods are used for the post-transplantation evaluation of the graft parenchyma and vascular anatomy, as well as for the identification of possible complications. As the number of cases increases, it is fundamental that radiologists understand the surgical procedure and the postoperative anatomy, as well as to recognize the possible postoperative complications and their imaging aspects, with the aim of providing the best guidance in the postoperative management of transplant recipients.
Virtual reality in interventional radiology education: a systematic review
Authors: Gelmini And Yara Particelli , Duarte Márcio Luís , Assis André Moreira de , Guimarães Junior Josias Bueno , Carnevale Francisco César
Published: July 2021

Abstract The aim of this study was to compare virtual reality simulation with other methods of teaching interventional radiology. We searched multiple databases-Cochrane Library; Medline (PubMed); Embase; Trip Medical; Education Resources Information Center; Cumulative Index to Nursing and Allied Health Literature; Scientific Electronic Library Online; and Latin-American and Caribbean Health Sciences Literature-for studies comparing virtual reality simulation and other methods of teaching interventional radiology. This systematic review was performed in accordance with the criteria established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Best Evidence Medical Education (BEME) Collaboration. Eligible studies were evaluated by using the quality indicators provided in the BEME Guide No. 11 and the Kirkpatrick model of training evaluation. After the eligibility and quality criteria had been applied, five randomized clinical trials were included in the review. The Kirkpatrick level of impact varied among the studies evaluated, three studies being classified as level 2B and two being classified as level 4B. Among the studies evaluated, there was a consensus that virtual reality aggregates concepts and is beneficial for the teaching of interventional radiology. Although the use of virtual reality has been shown to be effective for skill acquisition and learning in interventional radiology, there is still a lack of studies evaluating and standardizing the employment of this technology in relation to the numerous procedures that exist within the field of expertise.
Post-bariatric body contouring surgery: analysis of complications in 180 consecutive patients
Authors: CINTRA JUNIOR WILSON , MODOLIN MIGUEL LUIZ ANTONIO , COLFERAI DIEGO RICARDO , ROCHA RODRIGO ITOCAZO , GEMPERLI ROLF
Published: July 2021

ABSTRACT Introduction: bariatric surgery is the main treatment for cases of severe obesity and body contour surgery to correct body dysmorphia resulting from weight loss. However, these procedures are associated with a significant number of postoperative complications. Objective: this study aims to analyze complications in post-bariatric patients undergoing body contour surgeries and correlating them with the age and BMI of these patients. Methods: the current study is a retrospective study evaluating 180 consecutive patients undergoing body contour surgery after bariatric surgery within a period of three years (2014-2016). Data such as age, gender, Body Mass Index before bariatric and plastic surgeries, type of surgery performed and complications were collected, and correlated the age as well as the BMI of the patients in the pre-bariatric (PB) and pre-plastic (PP) periods with the complications presented. Results: of the 180 patients evaluated, 91.7% were females (n = 165), and the mean age was 46.3 ± 1.7 years. The most performed surgery was abdominoplasty (48.9%), followed by mammaplasty (21.1%). Some complications occurred in 26.1% of the patients with partial dehiscence (40.4%) and seroma (14.9%) being the most frequent. Patients who presented complications had a higher mean age (50.8 years) than those who presented with no complications, and major complications accounted for 2.7% of the sample. Conclusions: a statistically significant number of surgeries progressed without complications and, when they occurred, there were minor complications in most of the sample. Complications were more frequent in older patients with some of them having a BMI over 30 Kg/m2.
Household pesticide exposure: an online survey and shelf research in the Metropolitan Region of Rio de Janeiro, Brazil
Authors: Galdiano Leandro Lopes da Silva , Baltar Valéria Troncoso , Polidoro Silvia , Gallo Valentina
Published: July 2021

Abstract: This study aimed to estimate household pesticide exposure in adult individuals in the Metropolitan Region of Rio de Janeiro, Brazil, and to verify the accessibility of these products in local and online businesses. The data were collected by an online questionnaire (1,015 responses) and a shelf survey in physical and online stores. Among the responses analyzed, 87.5% used pesticides in the previous year, most of which against mosquitoes (64.7%). The most common application method was aerosol spray (38.1%), and the most frequent places of use were bedrooms (29.7%) and living rooms (22.1%). About 30% of respondents reported invasion of pests, and the most common pests were ants (79.1%) and cockroaches (40.4%). Service area (71.6%) and kitchen (17.5%) were the most common storage locations. Approximately 91% of those who lived with children aged under 18 used pesticides. The use of chemical group of pyrethroids prevailed (81.6%), and 90.8% of the reportedly used products are class II [55.7% (highly toxic)] or class III [35.1% (medium toxic)]. The most significant amount of purchased products was in the pest category, followed by mosquitoes. More variety of products were available in online stores than in physical stores. The high exposure of the population to pesticides at household is a public health issue and confirms the need for studies that better assess the risks and consequences of chronic and low-dose exposure to these substances. It is essential to inform the population about the uncertainties and potential risks of indiscriminate use so that they can choose whether to use pesticides in their households.