bluuebunny/crossref_metadata_2025 huggingface dataset:
Mind the gap between non-activated (non-aggressive) and activated (aggressive) indoor fungal testing: impact of pre-sampling environmental settings on indoor air readings
Authors: Efthymiopoulos Spyros , Yasemin Aktas , Hector Altamirano
Published: December 2022

Indoor fungal testing has been within the researchers’ scope of interest for more than a century. Various sampling and analysis techniques have been developed over the years, but no testing protocol has been yet standardised and widely accepted by the research and practitioner communities. The diversity in fungal taxa within buildings with varied biological properties and implications on the health and wellbeing of the occupants and the building fabric complicates the decision-making process for selecting an appropriate testing protocol. This study aims to present a critical review of non-activated and activated approaches to indoor testing, with an emphasis on the preparation of the indoor environment prior to sampling. The study demonstrates the differences in the outcomes of non-activated and activated testing through a set of laboratory experiments in idealised conditions and a case study. The findings suggest that larger particles are particularly sensitive to the sampling height and activation, and that non-activated protocols, despite dominating the current literature, can significantly underestimate the fungal biomass and species richness. Therefore, this paper calls for better-defined and activated protocols that can enhance robustness and reproducibility across the research domain focused on indoor fungal testing.
El aterrizaje de la tecnología educativa y la transformación digital en nuestros colegios
Authors: Vázquez Valencia Diego
Published: December 2022

La tecnología ha llegado a nuestros colegios para quedarse, y contar con una estrategia para su aterrizaje es clave para encarar con seguridad una transformación digital real, efectiva y global. Hoy más que nunca necesitamos dar sentido a las posibilidades del mundo digital dentro del aula para enriquecer el proceso de aprendizaje de nuestro alumnado, dotándoles de la competencia digital necesaria para el mundo de hoy.
Rompiendo (literalmente) con lo tradicional
Authors: Capote González Alba
Published: December 2022

Algunas alumnas de 3.º del Grado en Educación Primaria hemos realizado un proyecto innovador que consiste en la reforma de los espacios de un centro educativo para mejorar el rendimiento del alumnado y aumentar el rendimiento del profesorado. Para ello, hemos elaborado una programación que se llevará a cabo a lo largo de un curso escolar, basada en investigaciones anteriores y utilizando un pretratamiento y un postratamiento cuya muestra se basa en los miembros que forman parte del colegio.
Las chicas no juegan a videojuegos
Authors: Sánchez Lastra Marcos
Published: December 2022

Tenemos muy claro que los chicos suelen jugar a videojuegos, pero ¿y en el caso de las niñas? En este artículo desmentiremos un estigma muy aceptado por la sociedad “Las chicas consumen más redes sociales que los chicos, pero no juegan a videojuegos”. Analizaremos el motivo por el que las chicas no acuden a terapia a pesar de presentar los mismos síntomas propios de la adicción.
The Role of Colonialism in Creating and Perpetuating Statelessness in Southern Africa
Authors:   Institute for Security Studies, Mbiyozo Aimee-Noel
Published: December 2022

Some of the largest stateless populations in the world are in Southern Africa. Statelessness in the region is primarily linked to colonial histories, border changes, migration, gender, ethnic and religious discrimination, and poor civil registry systems. Colonial and white minority rulers created and implemented multi-tiered citizenship systems – extending full rights only to settlers. Like all other aspects of society, colonizers based citizenship on ethnic exclusion, exploitation, and discrimination. Native Africans were forced into legal subordination with minimal rights that were superseded by those of white settlers. At independence, most Southern African countries adopted nationality laws based on the models of their former colonial rulers while making efforts to reverse the systems of discrimination. Efforts to redress the inequalities via nationality laws have had unintended and intended consequences on vulnerable populations and exacerbated statelessness. Xenophobia is another consequence of colonial heritage that has perpetuated statelessness. Colonial powers relied on political exclusion. They used violence to 'divide and conquer,’ creating and reinforcing racial, ethnic, and tribal clashes. In many parts of Southern Africa, we see an increase in xenophobia and nationalism as the emerging form of political exclusion, resulting in restrictive and repressive migration responses to prevent migrants from arriving or integrating into societies. There are concerning signs that states are instrumentalizing statelessness as a migration management tool. Rising nationalism and anti-migrant sentiments threaten to undo gains in the fight against statelessness.
Statelessness, Development, and Protection of ‘Disadvantaged Groups’: bridging the post-2030 sustainable development gaps
Authors:   University of Pittsburgh, Badewa Adeyemi
Published: December 2022

Statelessness constricts development opportunities, human capital and potentials of affected communities and persons over successive generations. The marginalisation of stateless persons, deprivation of their basic rights, legal recognition and access to essential services further induce their vulnerability and the risk of intergenerational statelessness. However, the nexus between statelessness and development remains poorly investigated amid the lack of coherent measures to address it. Hence, the need to understand the increased deprivations by statelessness and its conditions of vulnerability, suspicion, and exclusion, and the mismatch in the implementation of multilateral development programmes and national policies against statelessness. The paper maintains that neglect of stateless persons and communities by development actors and processes often lags them in global, regional, or national development. Although not explicitly encapsulated to address statelessness, the Sustainable Development Goals (SDGs) unlock significant opportunities, with relevance and applicability of several goals in this regard. Therefore, incorporating statelessness into the post-2030 development agenda is critical for addressing its challenges, and improving human security and conditions of stateless persons.
Políticas culturales y ciudadanía. Estrategias simbólicas para tomar las calles: Víctor Vich
Authors: Crispin Jairo
Published: December 2022

Vich, V. (2021). Políticas culturales y ciudadanía. Estrategias simbólicas para tomar las calles. CLACSO.
Para lograr una cultura para vivir en Paz - Hallazgos y Recomendaciones. Informe Final de la Comisión de la Verdad
Authors: Parada Bernal Miguel Ángel
Published: December 2022

Comisión para el Esclarecimiento de la Verdad, la Convivencia y la No Repetición. (2022). Para lograr una cultura para vivir en Paz en: Hallazgos y Recomendaciones. Informe Final. Hay futuro si hay verdad. Comisión de la Verdad.
Open Transcatheter Mitral Valve Implantation Into the Native Mitral Valve for Inoperable “Big MAC”
Authors: Stelzmueller Marie-Elisabeth , Zilberszac Robert , Laufer Guenther , Wisser Wilfried
Published: December 2022

Because of the growing population of older adult patients, the prevalence of severe mitral annulus calcification (“big MAC”) is increasing. The surgical techniques used to treat big MACs are technically demanding; despite the technical aspect, up to one-third of patients are considered too high risk for conventional surgery but are candidates for the coulisse technique, which is a procedure that implants a transcatheter valve into a native mitral annulus. The anterior leaflet is unfolded, thus reducing the risk of obstructing the left ventricular outflow tract and for paravalvular leak and avoiding valve migration. Preoperative planning, based on a computed tomography scan, is mandatory.
La precariedad en los programas de inclusión de tecnología en la educación básica en México en el siglo XXI
Authors: Trejo-Quintana Janneth , Oliver Espinoza Rubén
Published: December 2022

La precariedad se ha asociado a las condiciones sociales y económicas que engendra el capitalismo contemporáneo, por lo tanto, repercute en la educación. Por eso es relevante identificar las acciones que los gobiernos llevan a cabo para enfrentarla, así como examinar sus características. En este marco, se analizan los siete programas públicos de inclusión de tecnología en la educación que distintos gobiernos mexicanos han implementado desde 1997 hasta 2021. Con base en una investigación documental (exploratoria y descriptiva) y a partir de la construcción de una matriz analítica, se responden las preguntas ¿qué características han tenido los programas de inclusión de tecnología en la educación implementados en México en el siglo XXI? Y ¿Por qué no se han sostenido en el tiempo? Las respuestas señalan deficiencias en la gestión pública, persistencia de condiciones precarias en infraestructura básica, diseño de los programas desde una lógica instrumentalista de la tecnología educativa, concepción tecnocentrista del proceso educativo. Se confirma que los gobiernos muestran desinterés en diseñar una política de Estado en materia de inclusión de tecnología en la educación.
El papel de la educación para la prevención de violencias machistas. Estudio cualitativo en Lamu, Kenia
Authors: Fernández-Quiroga Ana , Terrón-Caro Teresa , Cárdenas-Rodríguez Rocío
Published: December 2022

Cada año, 15 millones de niñas se siguen casando antes de cumplir la mayoría de edad (UNICEF, 2020a); siendo esta una de las manifestaciones de la violencia y la desigualdad de género que sufren las mujeres junto con otros tipos de violencia como la física, la sexual y la económica. En Kenia, contexto en el que centramos nuestra aportación, el 35% de las jóvenes menores de 19 años ya ha tenido su primer hijo/a (Kenya National Bureau of Statistics «KNBS», 2015). Partiendo de estas premisas y teniendo en cuenta que la educación es una herramienta para combatir la Violencia hacia las mujeres, la investigación que presentamos tiene como uno de sus principales objetivos analizar la influencia de la educación en la prevención de las Violencias Machistas, especialmente respecto al matrimonio infantil, así como la violencia económica o los abusos sexuales desde el punto de vista de las propias mujeres, jóvenes de distintos orígenes étnicos. Para alcanzar dicho fin, vamos a utilizar una metodología de corte cualitativo, utilizando la entrevista (en profundidad y semi-estructurada) a mujeres y agentes clave como principal instrumento de recogida de información. El estudio se contextualiza en Lamu, isla de Kenia. En las conclusiones establecemos que, aunque todavía deben revisarse los procesos y contenidos educativos para evitar la transmisión de estereotipos sexistas y discriminatorios, la educación es una estrategia para retrasar los matrimonios infantiles y prevenir otras manifestaciones de violencia machista, asimismo, se concibe como una forma de alcanzar la independencia económica de las mujeres.
Homiletická otázka je otázka otevřená
Authors: Macek Ondřej
Published: December 2022

The Homiletic Question is an Open Question. The professor of practical theology, Josef Smolík (1922–2009), whose hundredth anniversary of birth was in March of this year, concluded his textbook on homiletics with the remark that until the arrival of the Kingdom of Heaven we will seek means of conveying the Gospel to our contemporaries. The present article points out several contemporary homiletic questions. It focuses, for instance, on the views of Manfred Josuttis, Christian Möller, Isolde Karle, Albrecht Grözinger, Helmut Schwier, Birgit Weyel, Wilhelm Gräb, Hans-Günter Heimbrock, etc., on the power of God, on the role of the pastor as a witness, on the reflection of the listener and his world, and also on the place of the sermon in a church service. The article is divided into five sub-chapters: sermon, listener, pastor, Bible, church service. Special focus is given to topics in material homiletics.
An Example of Innovative Teaching: How to Start and Run a Financial Investment Company from a Finance and Accounting Perspective?
Authors: Kohli Raj K. , Pant Anurag
Published: December 2022

An example of an account of practice is presented in this paper. Such action learning methods are highly desired in the attempts to make our courses experiential.  Specifically, this project is a new idea for applying and enhancing an undergraduate Capstone Finance course (F444) as well as for a Graduate Financial Management Course (F542). This project guides students to start a new investment company in the State of Indiana and then run it during the semester.   As part of an advanced financial course, students maintain and grow an actual portfolio of securities, called Student Managed Investment Fund (SMIF). Hands-on training of this kind is expected to lead to stronger learning of concepts, better application of theories, and significantly more student satisfaction.
The Effect of Auditors’ Accountability, Independence, and Experience on Audit Service Quality (Survey on Public Accounting Firms in DKI Jakarta in 2022)
Authors: Hernawan Rivatedi Rona , Setiyawati Hari
Published: December 2022

The public accounting profession has an important role in auditing financial statements in an organization and is a profession of public trust. Public accountants, tasked with assessing and verifying the financial statements issued by the company's management, and ultimately provide their opinion on the financial statements they have audited. This study examines the effect of accountability, independence, and auditors' experience on the quality of audit services and the impacts on clients' satisfaction at Public Accounting Firms in DKI Jakarta in 2022. The population of this study was 221 Public Accounting Firms in Jakarta, and the samples were 90 auditors. The data were obtained by using a questionnaire. This study used Structural Equation Modeling (SEM) as the data analysis with PLS as the test tool. The results showed that accountability, independence, and auditors' experience had a significant positive effect on audit quality.
How has Globalisation Contributed to the Development of the Arab Countries Concept of Human Rights?
Authors: Almuqren Abdullah
Published: December 2022

"Human rights emanate from a European, Judeo-Christian, and/or Enlightenment heritage (typically labelled Western) and cannot be enjoyed by other cultures that don’t emulate the conditions and values of "Western" societies." (Shaheed and Richter, 201). According to this perception, the term "human rights" is seen to be fundamentally a set of Western values. This study seeks to question this assertion by investigating the origins of rights in both secular and religious societies. It is proposed to examine if human rights are truly a product of the Judeo-Christian Enlightenment that should be enforced onto those countries who do not, on the face, appear to share such human values. While universality and globalisation may be justified and beneficial to international trade and economic growth, their suitability for what can be seen as a colonialism of ideas and values is at the very least questionable (Mikander, 2016). This paper does not propose a judgement on the value of source, be it human or divine, but simply suggests that entry to the global political, economic and trading markets imposes an obligation on Islamic states to adopt United Nations standards. Thus, the purpose of this paper is to investigate how globalisation has affected the spread of Western values and to what extent it can be argued that this is a new form of neo-Western colonialism carried out through trade, wealth, and the promise of a brighter economic future for developing countries.
Effect of non-return valves on the time-of-arrival of new medication in a patient after syringe exchange in an infusion set-up
Authors: Konings Maurits K. , Gevers Robin , Mejri Sabrine , Timmerman Annemoon M.
Published: December 2022

The presence of a non-return valve in an infusion set-up is expected to affect the time-of-arrival of new medication in a patient after syringe exchange. Using Computational Fluid Dynamics (CFD) we have studied the flow through a typical non-return valve, focusing on two separate effects: (A) the overall delay in the time-of-arrival, and (B) timing effects due to the distortion of the Poiseuille flow profile in the non-return valve. The results show that (A) the additional delay in time-of-arrival of new medication, caused by the non-return valve alone, corresponds to the delay that would be caused by 11.2 cm of extra infusion line instead of the valve, and that (B) the non-Poiseuille flow profile inside the non-return valve gives rise to an extra slow wash-out of the last portion of the remnant fluid of the old medication. We conclude that awareness of these extra delays may be important for clinicians in certain time-critical situations.
Variation of canonical height for\break Fatou points on ℙ1
Authors: DeMarco Laura , Mavraki Niki Myrto
Published: December 2022

Let

f
:

ℙ
1

→

ℙ
1

{f:\mathbb{P}^{1}\to\mathbb{P}^{1}}

be a map of degree

>
1

{>1}

defined over a function field

k
=

K
⁢

(
X
)

{k=K(X)}

, where K is a number field and X is a projective curve over K. For each point

a
∈

ℙ
1

⁢

(
k
)

{a\in\mathbb{P}^{1}(k)}

satisfying a dynamical stability condition, we prove that the Call–Silverman canonical height for specialization

f
t

{f_{t}}

at point

a
t

{a_{t}}

, for

t
∈

X
⁢

(

ℚ
¯

)

{t\in X(\overline{\mathbb{Q}})}

outside a finite set, induces a Weil height on the curve X; i.e., we prove the existence of a

ℚ

{\mathbb{Q}}

-divisor

D
=

D

f
,
a

{D=D_{f,a}}

on X so that the function

t
↦

h
^

f
t

⁢

(

a
t

)

-

h
D

⁢

(
t
)

{t\mapsto\hat{h}_{f_{t}}(a_{t})-h_{D}(t)}

is bounded on

X
⁢

(

ℚ
¯

)

{X(\overline{\mathbb{Q}})}

for any choice of Weil height associated to D. We also prove a local version, that the local canonical heights

t
↦

λ
^

f
t

,
v

⁢

(

a
t

)

{t\mapsto\hat{\lambda}_{f_{t},v}(a_{t})}

differ from a Weil function for D by a continuous function on

X
⁢

(

ℂ
v

)

{X(\mathbb{C}_{v})}

, at each place v of the number field K. These results were known for polynomial maps f and all points

a
∈

ℙ
1

⁢

(
k
)

{a\in\mathbb{P}^{1}(k)}

without the stability hypothesis,
[21, 14],
and for maps f that are quotients of endomorphisms of elliptic curves E over k and all points

a
∈

ℙ
1

⁢

(
k
)

{a\in\mathbb{P}^{1}(k)}

. [32, 29].
Finally, we characterize our stability condition in terms of the geometry of the induced map

f
~

:

X
×

ℙ
1

⇢

X
×

ℙ
1

{\tilde{f}:X\times\mathbb{P}^{1}\dashrightarrow X\times\mathbb{P}^{1}}

over K; and we prove the existence of relative Néron models for the pair

(
f
,
a
)

{(f,a)}

, when a is a Fatou point at a place γ of k, where the local canonical height

λ
^

f
,
γ

⁢

(
a
)

{\hat{\lambda}_{f,\gamma}(a)}

can be computed as an intersection number.
Examining the application of nominalization in segmented abstracts: a corpus-based study
Authors: Yuan Yuwei
Published: December 2022

The aim of this study was to explore the use of nominalizations in segmented abstracts, examining their distribution and characteristics and whether they differ from traditional non-segmented abstracts in terms of the use of nominalizations. The study adopted a corpus-based approach, querying nominalization tokens using suffixes of nominalization, to analyse different sections of abstracts from 30 research articles in the American Journal of Psychiatry. Statistical analysis revealed that the Conclusions section among the four sections (Objective, Methods, Results, and Conclusions) utilized nominalizations most frequently, and a significant difference was found in the frequency of nominalizations between the four sections. The most frequently used suffixes of nominalization were -sion/-tion, followed by -ment and -ity, all of which reflected the functions of nominalization such as information condensation, cohesion construction, and agent or doer avoidance. Segmented abstracts show distinct strategies for the adoption of nominalizations in different sections. This study will contribute to English for Specific Purposes (ESP) in writing research articles.
The presence of person-centered language in orthopedic-related amputation research: a cross-sectional analysis
Authors: Reddy Arjun K. , Norris Grayson R. , Nayfa Rob , Sajjadi Nicholas B. , Checketts Jake X. , Scott Jared T. , Hartwell Micah
Published: December 2022

Context

Amputations are routine in orthopedics, specifically during trauma and when patients have recurrent surgical site infections. When undergoing amputations, patients must combat the psychosocial factors associated with the loss of an extremity, including stigmatization.

Objectives

This study analyzes the presence of person-centered language (PCL) within amputation-related orthopedic publications in the top orthopedic journals.

Methods

We conducted a cross-sectional analysis with a database search on February 14, 2021 utilizing PubMed. Utilizing a previously published search string, we isolated studies that were published in the top 20 orthopedic journals based on the Google h5-index. In addition to the top 20 orthopedic journals, we included the top two hand and foot & ankle journals in our search to incorporate more amputation literature. Our search yielded 687 returns. The sample was then randomized, and the first 300 studies that fit our inclusion criteria were examined for prespecified non-PCL terminology.

Results

Our results show that 157 (52.2%) studies were adherent to PCL according to the American Medical Association’s Manual of Style 10th Edition (AMAMS). Of the 143 (47.7%) studies that were not adherent to PCL, 51 studies (35.7%) had more than one type of non-PCL language. The term “amputee,” which is being labeled as identity-first language (IFL), was found in 101 articles (33.7%). Further investigation found that 73.3% (74/101) of the studies containing IFL were found to have other non-PCL terms. Of the other studies in the sample, non-PCL was found 34.7% (88/199) of the time. This analysis was done due to the discrepancies in stigmatization of the term “amputee.” No statistical association was found between adherence to PCL and study characteristics.

Conclusions

Our findings show that amputation literature within the top orthopedic journals has limited adherence to PCL. Additionally, the use of the term “amputee,” which is widely accepted by the amputation community, resulted in a greater rate of non-PCL terminology within orthopedic amputation literature. Efforts should be implemented within orthopedics to avoid the use of stigmatizing language, regarding individuals that underwent amputations, to minimize psychosocial stressors.
Globale Produktionsstrategien in der Praxis – Strategieformulierung und -implementierung
Authors: Gerhard Schalm Karl , Kaiser Jens , Friedli Thomas
Published: December 2022

Basierend auf Benchmarkingdaten von 68 Industrieunternehmen und vertiefenden Expertenbefragungen bietet dieser Beitrag eine Orientierung für die Formulierung und Implementierung von globalen Produktionsstrategien. In der Formulierung stellen die Zusammenarbeit mit dem Topmanagement und eine konsistente Einbettung in die Unternehmensstrategie Erfolgsfaktoren dar. Hoshin Kanri und die Balanced Scorecard sind dabei die am häufigsten verwendeten Methoden zur erfolgreichen Implementierung.
Wie effizient sind gleichspannungsversorgte Maschinen?
Authors: Kuhlmann Timm , Zeiser Reinhard , Hohmann Andrea , Sauer Alexander
Published: December 2022

Steigende Strompreise erhöhen den Druck auf Unternehmen eine Vielzahl an Maßnahmen zur Reduktion des Energieverbrauchs zu realisieren. Die Versorgung von Maschinen aus einem Gleichspannungsnetz (DC-Netz) birgt ein hohes Effizienzpotenzial und bietet so eine Möglichkeit zur Energieverbrauchsreduktion. Dieses kann aber nicht pauschal, sondern muss auf Grund der unterschiedlichen Maschinenstrukturen, Prozessabläufe und Leistungsbedarfe individuell abgeschätzt werden. Die hier vorgestellte Messmethode und das entwickelte Messsystem ermöglichen ein einfaches Erfassen des zu erwartenden Potenzials bei Umrüstung einer Maschine auf DC.
Gestational diabetes and its correlation with maternal socio-demographic characteristics
Authors: Jubrael Nask , Alalaf Shahla , Shabila Nazar , Ali Salah
Published: December 2022

Background and objective: Gestational diabetes mellitus is the most common metabolic disorder of pregnancy with increasing prevalence at epidemic rates. This study aimed to determine the prevalence of gestational diabetes mellitus and related risk factors in a sample of pregnant women in Erbil city. Methods: A cross-sectional study was conducted on a convenience sample of 216 pregnant women at primary health care centers in Erbil city, Kurdistan Region, Iraq, from April 2019 to January 2021. The pregnant women were selected independent of having or not having risk factors. Pregnant women were screened for diabetes mellitus using 50 gm glucose challenge test in 24–28th weeks of gestational age. Women with positive glucose challenge test underwent 100 g glucose tolerance test. Results: The 50g glucose challenge test revealed that 54 women (25.0%) were positive for gestational diabetes mellitus. Glucose tolerance test (100 gm) revealed that the prevalence of diabetes among the sample was 11.9%. The association between the different characteristics and risk factors with the diagnosed diabetic status of the study participants showed that there was a significant association with the older age, obesity, higher parity, and history of recurrent miscarriage. Conclusion: Pregnancy is associated with a high prevalence of gestational diabetes mellitus in the current research. Pregnant women, particularly those in advanced maternal age, with pre-pregnancy high body mass index and having a history of recurrent miscarriages, should be investigated for the possibility of the presence of gestational diabetes mellitus.
Tranexamic acid for the prevention of postpartum hemorrhage and decreasing blood loss after vaginal delivery in high-risky parturient: A double-blind randomized controlled trial
Authors: Hasan Chro , Alalaf Shahla , Khoshnaw Sazgar
Published: December 2022

Background and objective: The purpose of this study was to examine the effectiveness of Tranexamic acid administered in the third stage of labor to reduce vaginal blood loss and prevent postpartum hemorrhage in women with high-risk factors for postpartum Hemorrhage. Methods: A double-blind randomized placebo-controlled trial with two parallel groups was conducted in women scheduled to undergo vaginal delivery at the Maternity Teaching Hospital, Erbil city, Kurdistan Region, Iraq. The women were randomly assigned to receive tranexamic acid (97 women) or placebo (99 women) immediately after fetal delivery in the third stage of labor. The vaginal blood loss and the time from fetal to placental delivery were measured. Results: The mean blood loss in the placebo group (Group 1) was 354.5 gram, which was considerably greater than the mean blood loss in the tranexamic group (Group 2), which was 284.4 gram. The incidence of postpartum hemorrhage (blood loss of ≥500 ml.) and (blood loss of ≥250 ml.) was significantly higher in G1 than G2. The length of the third stage of labor lasted 10.28 minutes in G1, which was longer than in G2, which lasted 7.82 minutes. Oxytocin was given to both groups as an active management of the third stage of labor. Conclusion: In this single-center study, women with risk factors for postpartum hemorrhage who received tranexamic acid had lower postpartum blood loss and a shorter time for placental delivery than those women who received placebo. Larger multicenter randomized clinical trials are needed to generalize these findings.
The Phytochemical assay, and in vitro assessment of the antioxidant, antibacterial, and anti-inflammatory properties of Beta vulgaris L. (Amaranthaceae), and Corchorus olitorius L. (Malvaceae) crude leaf extracts
Authors: Adham Aveen
Published: December 2022

Background and objective: The traditional herbs Beta vulgaris and Corchorus olitorius are cultivated in Iraq and recorded in the Kurdish ethnobotany for various health problems including expectorant, laxative, diuretic, and anti-inflammatory and to relieve fever and pain. This study aimed to assess and compare the different biological properties of methanolic leaf extracts of Beta vulgaris and Corchorus olitorius cultivated in Iraq and recognize various classes of phytoconstituents present in each one. Methods: The bioactive entities in the crude methanolic leaves extracts of Beta vulgaris and Corchorus olitorius were subjected to phytochemical evaluations. The antioxidant and anti-inflammatory activities were evaluated with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and egg albumin denaturation assays, respectively. The leaf extracts were tested for antibacterial properties using the agar well diffusion and broth microdilution methods. Results: The crude methanolic extracts of Beta vulgaris and Corchorus olitorius showed the presence of carbohydrates, alkaloids, cardioactive glycosides, coumarins, flavonoids, phenols, tannins, terpenoids, and steroids. The Beta vulgaris displayed higher gallic acid content 417.90±0.52 mg/gm of the extract compared to 79.85±0.99 mg/gm for Corchorus olitorius with (P <0.001).The antioxidant activity of Beta vulgaris leaves extract was significantly higher with (P = 0.035) in reference to ascorbic acid. Among the selected bacterial species, Klebsiella pneumoniae revealed pronounced sensitivity towards the methanolic extracts of both plants. The Corchorus olitorius leaves extract showed higher antibacterial activity than Beta vulgaris. Beta vulgaris presented greater anti-inflammatory activity at 1000 μg/mL with inhibition of 93.0% compared to 83.2% using acetylsalicylic acid as positive control. Conclusion: The methanolic leaf extracts of Beta vulgaris and Corchorus olitorius possess antibacterial, antioxidant, and anti-inflammatory potentials.
AKSARAY GÜZELYURT GELVERİ EKMEĞİ VE YASSI EKMEK ÜRETİMİ
Authors: KOÇAN Deniz
Published: December 2022

Gelveri Ekmeği hiçbir katkı kullanılmadan; tam buğday unu, maya, tuz ve sudan üretilmektedir. Gelveri Ekmeğinde mayalama ekşi hamurla sağlanmaktadır. Ekşi hamur kültüründe bulunan Lactobacillus spp. çok miktarda laktik asit ve asetik asit üretmektedir. Bu da ekşi hamur ekmeğine kendine özgü lezzet vermektedir. Gelveri Ekmeği coğrafi işaret ile tescillenmiştir. Güzelyurt Kapadokya Bölgesi’nin karakteristik çizgilerini taşır. Bunun en önemli belirtisi ise kaya oluşumları ile dolu olmasıdır. Kayalardan yapılmış fırınlarda asırlardır yapılan Gelveri Ekmeği yöre halkının hâlâ devam ettirdiği geleneklerden biridir. Güzelyurt ve çevre ilçelerde de tanınan Gelveri Ekmeği dayanıklılığı ile bilinmektedir.
Multiple endocrine neoplasia type 4: a new member of the MEN family
Authors: Singeisen Hélène , Melanie Renzulli Mariko , Pavlicek Vojtech , Probst Pascal , Hauswirth Fabian , Muller Markus K , Adamczyk Magdalene , Weber Achim , Kaderli Reto Martin , Renzulli Pietro
Published: December 2022

Objective

Multiple endocrine neoplasia type 4 (MEN4) is caused by a CDKN1B germline mutation first described in 2006. Its estimated prevalence is less than one per million. The aim of this study was to define the disease characteristics.

Methods

A systematic review was performed according to the PRISMA 2020 criteria. A literature search from January 2006 to August 2022 was done using MEDLINE® and Web of ScienceTM.

Results

Forty-eight symptomatic patients fulfilled the pre-defined eligibility criteria. Twenty-eight different CDKN1B variants, mostly missense (21/48, 44%) and frameshift mutations (17/48, 35%), were reported. The majority of patients were women (36/48, 75%). Men became symptomatic at a median age of 32.5 years (range 10–68, mean 33.7 ± 23), whereas the same event was recorded for women at a median age of 49.5 years (range 5–76, mean 44.8 ± 19.9) (P  = 0.25). The most frequently affected endocrine organ was the parathyroid gland (36/48, 75%; uniglandular disease 31/36, 86%), followed by the pituitary gland (21/48, 44%; hormone-secreting 16/21, 76%), the endocrine pancreas (7/48, 15%), and the thyroid gland (4/48, 8%). Tumors of the adrenal glands and thymus were found in three and two patients, respectively. The presenting first endocrine pathology concerned the parathyroid (27/48, 56%) and the pituitary gland (11/48, 23%). There were one (27/48, 56%), two (13/48, 27%), three (3/48, 6%), or four (5/48, 10%) syn- or metachronously affected endocrine organs in a single patient, respectively.

Conclusion

MEN4 is an extremely rare disease, which most frequently affects women around 50 years of age. Primary hyperparathyroidism as a uniglandular disease is the leading pathology.
Das Gesetz über den Stabilisierungs- und Restrukturierungsrahmen für Unternehmen (StaRUG) aus Bankensicht
Authors: Brinkmann Moritz
Published: December 2022

Das am 1. Januar 2021 in Kraft getretene Gesetz über den Stabilisierungs- und Restrukturierungsrahmen für Unternehmen hat die Rahmenbedingungen für Restrukturierungsverhandlungen in Deutschland erheblich verändert. Der Beitrag stellt die Neuregelung im Überblick vor und beleuchtet dann insbesondere die Position von Banken in Restrukturierungsverfahren. Dabei werden auch bankaufsichtsrechtliche Aspekte berücksichtigt. Abschließend werden die Konsequenzen der neuen Rechtslage für das Distressed Debt trading erörtert.
Designing a Master Course on Architectures for Big Data: A Collaboration between University and Industry
Authors: Condorelli Andrea CONDORELLI , Malchiodi Dario
Published: December 2022

We describe a collaboration between Marelli and Università degli Studi di Milano that allowed the latter to add a course on «Architectures for Big Data» in its Master programme of Computer Science, with the aim of providing a teaching approach characterized by an intertwined exposition of discipline, methodology and practical tools. We were motivated by the need of filling, at least in part, the gap between the expectation of employers and the competences acquired by students. Indeed, several big-data-related tools and patterns of widespread use in working environments are seldom taught in the academic context. The course also allowed to expose students to company-related processes and topics. So far, the course has been taught for two editions, and a third one is currently ongoing. Using both a quantitative and a qualitative approach, we show that students appreciated this new form of learning activities, in terms of enrollments, exam marks, and activated external theses. We also exploited the received feedback in order to slightly modify the content and the structure of the course.
Challenging the Patriarchal Norms: Examining Hegemonic Masculinity in Dickinson TV Series
Authors: Rahmawati Andieni , Syahriyani Alfi
Published: December 2022

In the 19th century, hegemonic masculinity and patriarchal system were part of the society and even became the norms that people believed and obeyed. Emily Dickinson, a female character in Dickinson series, had to deal with gender discrimination practiced by the patriarchal society, specifically hegemonic masculine figure. This research aims to investigate the hegemonic masculinity experienced by the main female character in Dickinson season 1, and how she challenged the notion of hegemonic masculinity. The writer uses descriptive qualitative method as well as the theory of hegemonic masculinity by Raewyn Connell. This study found that there were various traits of hegemonic masculinity that Emily had to face from the hegemonic masculine figure, namely authority, aggression, technical competence, and subordination of women. It also showed that the character in the series tried to challenge the hegemonic masculinity performed by her hegemonic father. The acts proved that the female character put effort in fighting againts the injustice and discrimination toward her as a woman.
Length of Stay and Barriers to Discharge for Technology-Dependent Children During the COVID-19 Pandemic
Authors: Rush Margaret , Khan Amina , Barber John , Bloom Miriam , Anspacher Melanie , Fratantoni Karen , Parikh Kavita
Published: December 2022

BACKGROUND AND OBJECTIVE:

During the coronavirus disease 2019 pandemic, technology-dependent children are at risk of encountering barriers to hospital discharge because of limits to in-home services. Transition difficulties could increase length of stay (LOS). With this study, we aim to (1) evaluate change in LOS and (2) describe barriers to hospital discharge between prepandemic and early pandemic periods for technology-dependent children.

METHODS:

A retrospective chart review of technology-dependent children discharged from an acute and specialty pediatric hospital within a single urban area between January 1 and May 28, 2020 was conducted. Technology dependence was defined by using a validated complex chronic condition coding system. Patients discharged prepandemic and during the pandemic were compared. Outcomes included LOS and the number and type of discharge barriers (a factor not related to a medical condition that delays discharge). Multivariate regression modeling and parametric and nonparametric analysis were used to compare cohorts.

RESULTS:

Prepandemic, 163 patients were discharged, and 119 were discharged during the early stages of the pandemic. The most common technology dependence was a feeding tube. The unadjusted median LOS was 7 days in both groups. After adjusting for patient-level factors, discharge during the pandemic resulted in a 32.2% longer LOS (confidence interval 2.1%–71.2%). The number of discharge barriers was high but unchanged between cohorts. Lack of a trained caregiver was more frequent during the pandemic (P = .03).

CONCLUSIONS:

Barriers to discharge were frequent for both cohorts. Discharge during the pandemic was associated with longer LOS. It was more difficult to identify a trained caregiver during the pandemic.
Historicko‑demografické bádanie na Slovensku
Authors: Tišliar Pavol
Published: December 2022

The paper deals with an overview of historical‑demographic research in Slovakia. It names selected important works that contributed to the enlihtenment of the population history of Slovakia and personalities who directly addressed this issue. The paper pays particular attention to the institutionalization of historical‑demographic research in Slovakia and workplaces. There, the paper focuses on demographic research, especially in terms of the projecting and publishing area.
Vitamin D sufficiency and the effect of its deficiency on the course of allergic diseases in children
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Marushko Yu.V. , Yesipova S.I. ,   Bogomolets National Medical University, Kyiv, Ukraine, Hyshchak T.V. ,   Bogomolets National Medical University, Kyiv, Ukraine,, Boyko N.S. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: December 2022

The prevalence of allergic pathology is increasing significantly in both adults and children, and at the same time, the problem of vitamin D deficiency remains relevant. Recent studies have revealed a close connection between vitamin D deficiency and the development of allergic diseases in children. In addition to its role in bone and calcium metabolism, recent observations have shown its possible role as an immunomodulator in allergic diseases. This is due to the presence of vitamin D receptors in most cells of the human body. One of the most important functions of vitamin D is to modulate the response of the immune system, both innate and adaptive. Currently, there is no consensus on the possible mechanisms of vitamin D involvement in the pathogenesis of allergies. It is believed that the role of vitamin D in the pathogenesis of allergic diseases is due to its regulatory effect on the immune system, participation in antimicrobial protection and ensuring the barrier function of the skin and mucous membranes. In this regard, considerable attention is paid to the study of the role of vitamin D in the development and course of allergic diseases in children. Purpose - to summarize the literature data on the biological role of vitamin D and the impact of its deficiency on the course of allergic diseases in children. Results and conclusions. In most scientific studies, the adverse effect of vitamin D deficiency on the allergic process has been established - an insufficient level of 25(OH)D in blood serum was found in children with asthma, allergic rhinitis, atopic dermatitis and food allergies. Also, a number of authors found a connection between the status of vitamin D and the risk of development and exacerbation of an allergic disease or indicators of a severe course. Although other researchers deny such relationship. Despite the inconsistencies in the literature, it is possible to note the important role of vitamin D in the development and course of allergic diseases in children. No conflict of interests was declared by the authors.
High frequency of the 472AA COMT (Val158) homozygous genotype of the catechol-O-methyltransferase (COMT) gene in children with irritable bowel syndrome
Authors:   Danylo Halytsky Lviv National Medical University, Ukraine, Semen M.O. , Lychkovska O.L. ,   Danylo Halytsky Lviv National Medical University, Ukraine, Shymanska I.E. ,   Institute of Hereditary Pathology of the NAMS of Ukraine, Lviv, Semen V.D. ,   Lviv Regional Children’s Clinical Hospital «OHMATDYT», Ukraine, Makukh H.V. ,   Institute of Hereditary Pathology of the NAMS of Ukraine, Lviv
Published: December 2022

Following the biopsychosocial model of medicine, the pathophysiological basis of irritable bowel syndrome (IBS) is a combination of biological, psychoemotional, and psychosocial factors, the contribution of each of them to the development of this disorder remains unclear. Psychoemotinal factors, which are involved in the pathogenesis of IBS, are caused not only by the environment but also by the metabolism of catecholamines, particularly by the functional activity of catechol-O-methyltransferase (COMT). Purpose - to determine the role of Val158Met COMT polymorphism in development of IBS in children; to identify associations between genotype and clinical variant of the disorder and the nature of the provoking factor. Materials and methods. The material for the molecular genetic study were DNA samples obtained from nuclear cells of venous blood of 54 patients aged 6-12 years with diagnosed IBS. In 48 practically healthy children of the same age DNA samples were isolated from buccal epithelial cells. Molecular genetic study of single nucleotide polymorphism rs4680 of COMT gene was performed by polymerase chain reaction followed by analysis of restriction fragment length polymorphism. Microsoft Excel 2016 and GraphPad Prism 5 software were used for statistical analysis. Results. We have revealed significant differences in the distribution of Val158Met COMT genotypes in children with IBS in comparison with the control group. There was established that the 472GА COMT is more prevalent in healthy children and has a protective role in the development of IBS. In contrast, homozygous genotypes 472GG and 472AA, which are associated with changes in functional activity of enzyme COMT, may be considered as the risk factors for IBS (p≤0.0001). Conclusions. Genotype 472АА COMT was mostly detected in сhildren with stress-associated IBS, which is more related to dysnociception, disorders of cognition, and emotional disturbances. The higher prevalence of 472GA COMT heterozygotes among children with postinfectious IBS and IBS associated with antibiotic therapy indicates a less important role for the psychoemotional component and nociceptive disorders in the onset of this disorder (p=0.03). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
APPLICATION OF WAQF IN MODERN ISLAMIC BOARDING SCHOOL DARUSSALAM GONTOR PONOROGO REGENCY IN THE PERSPECTIVE OF SHARIA ECONOMIC LAW AND LAW NUMBER 41 OF 2004 CONCERNING WAQF
Authors: Taufik Fikfik , Aprillillah Yusi Nur Iman
Published: December 2022

Pondok Modern Darussalamm Gontor is an example of an educational institution that is successful in managing waqf by Nazir organizations. Because individual nazirs tend to be lay and they are afraid that waqf assets will not be managed properly. However, PMDG carries out waqf activities with the concept of fund raising, one of which is not regulated in Law No. 41 of 2004 concerning waqf, namely self waqf which is still used today. The research method used is a normative juridical approach. This research was conducted by examining library materials as the basic material for research, by conducting a search on legislation and literature related to the problem under study. The basis of the implementation of this self-waqf is maqashid sharia, namely realizing benefit and avoiding harm. This is in accordance with the thinking of the Maliki School and the Hanafi School, with the background of its implementation being Law No. 41 of 2004 article 16 no. 3 point g. Therefore, self waqf is still carried out because there is a noble goal, namely: to continue the leadership relay and PMDG ideals if the leader dies.
The possibility of osteoporosis and avascular necrosis caused by the COVID-19 pandemic. Analysis of literature
Authors: Prytula Nataliya , Fedotova Inga , Golbaum Maksym
Published: December 2022

The SARS-CoV-2 (COVID-19) coronavirus pandemic has prompted scientific research. Hypotheses regarding its pathogeneticmechanisms and treatment are formulated, unwanted consequences of the infection are determined. Objective. To provideuseful information for clinicians about possible complications from the musculoskeletal system after COVID-19 for thetimely application of effective methods of their prevention. Materials: Electronic databases PMC, PubMed and Scopus wereused to search for the sources of information published from December 2019 to December 2021. The full text of the articleswas reviewed to confirm their relevance to the stated purpose of the review. Results. Patients after a severe course of SARSCoV-2 have a high risk of complications such as osteoporosis and avascular osteonecrosis due to a number of reasons. It isnoted that hypocalcemia is considered as an indicator of the severity and progression of the course of COVID-19. Vitamin Ddeficiency increases the risk of contracting COVID-19 and is associated with increased severity and mortality from the infection.Decreased proliferation and differentiation of osteoblasts can provoke elevated levels of cytokines under cytokine stormconditions. Hypoxia caused by SARS-CoV-2 is an important factor in increasing the differentiation and activity of osteoclastsand, accordingly, increasing osteoresorption. The relationship between the development of avascular osteonecrosis and longterm use of high doses of corticosteroids in patients with severe acute respiratory syndrome has been established. Conclusions. Research of musculoskeletal complications after COVID-19 is ongoing for correct forecasting and effective prevention. The use of corticosteroids in the treatment of patients with COVID-19 should be considered. It is necessary to pay attention to the diagnosis of osteoporosis, since there are many risk factors for increased bone fragility in hospitalized patients. Patients suffering from the effects of COVID-19 will need a comprehensive recovery and rehabilitation treatment plan