bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonal Impact on Free Flap Surgery in Terms of Flap Loss and Wound Healing Disorders: A Retrospective Cohort Study of 158 Free Flaps
Authors: Klietz Marie-Luise , Mewe Chiara , Wiebringhaus Philipp , Hirsch Tobias , Aitzetmüller Matthias Michael , Kückelhaus Maximilian
Published: January 2023

(1) Background: Postoperative flap loss and wound healing disorders are severe complications after microsurgical free flap surgery. Despite multiple clinical observations, a possible influence of season and external temperature on outcome are largely missing. (2) Methods: Retrospectively, data were collected from 151 patients receiving microsurgical free flaps from March 2018 to August 2019. Patients were divided into two cohorts. The winter group includes all patients who underwent surgery from October 2018 to March 2019 and the summer group al those who underwent surgery from April 2018 to September 2018. Data included demographic information, pre-existing conditions, flap characteristics, and postoperative complications like flap losses and wound healing problems. External temperatures during the first 14 postoperative days were documented and the predictor of flap loss and wound healing disorders was detected. (3) Results: In the winter group (October-March; Ø 7.24 °C) 72 patients (46 female, 24 males; Ø 57.0 years) and in the summer group (April-September; Ø 18.79 °C) 81 patients (48 female, 33 males; Ø 56.0 years) received free flap surgery. There were no significant differences in demography (age: p = 0.593; gender: p = 0.419; BMI: p = 0.141). We found a significant increase in flap loss during summer (χ2(1) = 6.626; p = 0.010; V = 0.209) strengthened by logistic regression analysis (p = 0.037; Exp(B) = 9.655). Additionally higher average temperatures 14 days postoperatively represents another main driver (p = 0.023, Exp(B) = 1.161) for postoperative flap loss. (4) Conclusions: The data confirm a significantly higher postoperative flap loss in the summer group. This information may potentially contribute to optimization of perioperative management and planning of elective and semi-elective surgeries.
Association between Prehospital Visits and Poor Health Outcomes in Korean Acute Stroke Patients: A National Health Insurance Claims Data Study
Authors: Shin Jinyoung , Kim Hyeongsu , Kim Youngtaek , Moon Jusun , Lee Jeehye , Jung Sungwon , Hwang Rahil , Kim Mi Young
Published: January 2023

This study aimed to determine whether prehospital visits to other medical institutions before admission are associated with prolonged hospital stay, readmission, or mortality rates in acute stroke patients. Using the claims data from the Korean Health Insurance Service, a cross-sectional study was conducted on 58,418 newly diagnosed stroke patients aged ≥ 20 years from 1 January 2019 to 31 December 2019. Extended hospital stay (≥7 days; median value) following initial admission, readmission within 180 days after discharge, and all-cause mortality within 30 days were measured as health outcomes using multiple logistic regression analysis after adjusting for age, sex, income, residential area, and medical history. Stroke patients with a prehospital visit (10,992 patients, 18.8%) had a higher risk of long hospitalization (odds ratio = 1.06; 95% confidence interval = 1.02–1.10), readmission (1.19; 1.14–1.25), and mortality (1.23; 1.13–1.33) compared with patients without a prehospital visit. Female patients and those under 65 years of age had increased unfavorable outcomes (p < 0.05). Prehospital visits were associated with unfavorable health outcomes.
Bayesian Hierarchical Framework from Expert Elicitation in the South African Coal Mining Industry for Compliance Testing
Authors: Made Felix , Kandala Ngianga-Bakwin , Brouwer Derk
Published: January 2023

Occupational exposure assessment is important in preventing occupational coal worker’s diseases. Methods have been proposed to assess compliance with exposure limits which aim to protect workers from developing diseases. A Bayesian framework with informative prior distribution obtained from historical or expert judgements has been highly recommended for compliance testing. The compliance testing is assessed against the occupational exposure limits (OEL) and categorization of the exposure, ranging from very highly controlled to very poorly controlled exposure groups. This study used a Bayesian framework from historical and expert elicitation data to compare the posterior probabilities of the 95th percentile (P95) of the coal dust exposures to improve compliance assessment and decision-making. A total of 10 job titles were included in this study. Bayesian framework with Markov chain Monte Carlo (MCMC) simulation was used to draw a full posterior probability of finding a job title to an exposure category. A modified IDEA (“Investigate”, “Discuss”, “Estimate”, and “Aggregate”) technique was used to conduct expert elicitation. The experts were asked to give their subjective probabilities of finding coal dust exposure of a job title in each of the exposure categories. Sensitivity analysis was done for parameter space to check for misclassification of exposures. There were more than 98% probabilities of the P95 exposure being found in the poorly controlled exposure group when using expert judgments. Historical data and non-informative prior tend to show a lower probability of finding the P95 in higher exposure categories in some titles unlike expert judgments. Expert judgements tend to show some similarity in findings with historical data. We recommend the use of expert judgements in occupational risk assessment as prior information before a decision is made on current exposure when historical data are unavailable or scarce.
Socioeconomic Macro-Level Determinants of Hypertension: Ecological Analysis of 138 Low- and Middle-Income Countries
Authors: Abba Mustapha S. , Nduka Chidozie U. , Anjorin Seun , Zanna Fatima H. , Uthman Olalekan A.
Published: January 2023

Aim: To assess the relative importance of major socioeconomic determinants of population health on the burden of hypertension in Low-and-Middle-Income Countries (LMICs). Methods: Country-level data from 138 countries based on World Development Indicators 2020 were used for correlation and linear regression analyses of eight socioeconomic predictors of hypertension: current health expenditure, domestic general government health expenditure per capita, GDP per capita, adult literacy rate, unemployment rate, urban population, multidimensional poverty index, and total population. Results: The median prevalence of age-standardised hypertension was 25.8% across the 138 countries, ranging from 13.7% in Peru to 33.4% in Niger. For every 10% increase in the unemployment rate, the prevalence of hypertension increased by 2.70%. For every 10% increase in the percentage of people living in urban areas, hypertension was reduced by 0.63%. Conclusions: The findings revealed that countries with high GDP, more investment in health and an improved multidimensional poverty index have a lower prevalence of hypertension.
Electrocardiographic Pathological Findings Caused by the SARS-CoV-2 Virus Infection: Evidence from a Retrospective Multicenter International Cohort Longitudinal Pilot Study of 548 Subjects
Authors: Susca Nicola , Solimando Antonio Giovanni , Borrelli Paola , Marziliano Donatello , Monitillo Francesco , Raimondo Pasquale , Vestito Domenico , Lopizzo Agostino , Brindicci Gaetano , Abumayyaleh Mohammad , El-Battrawy Ibrahim , Saracino Annalisa , Grasso Salvatore , Brunetti Natale Daniele , Racanelli Vito , Santoro Francesco
Published: January 2023

COVID-19 has threatened the capability of receiving and allocating patients in emergency departments (EDs) all over the world. This is a retrospective cohort study to explore the role of a simple procedure like an ECG to screen for the severity of COVID-19 on admission to the ED. For this study, 548 consecutive patients were enrolled in a multicenter international registry and stratified upon ECG on admission with a simple distinction between normal vs. abnormal rhythm. Among patients in the abnormal ECG group were those with heart rates higher than 100 beats per minute and/or atrial fibrillation. Survival in patients with normal ECG rhythm was deemed below 75% after 58 days and then stabilized, while survival in patients with abnormal ECG rhythm was deemed below 75% after 11 days and below 50% after 21 days. A multivariate analysis including abnormal rhythm, gender, age, diabetes, obesity, respiratory failure during hospitalization, heart failure during hospitalization, and abnormal rhythm was an independent predictor of death (HR 7.20 95% CI 3.63–14.28, p < 0.01). This finding, if confirmed in large prospective studies, is promising for identifying a cheap and simple procedure for patients in need of a closer look.
Arterial Blood-Flow Acceleration Time on Doppler Ultrasound Waveforms: What Are We Talking About?
Authors: Trihan Jean-Eudes , Mahé Guillaume , Laroche Jean-Pierre , Dauzat Michel , Perez-Martin Antonia , Croquette Magali , Lanéelle Damien
Published: January 2023

In recent years, the assessment of systolic acceleration in lower-extremity peripheral artery disease (PAD) has been brought back into the spotlight, whatever measure is used: time (in s) or acceleration (in cm.s−2). Acceleration time (also called systolic rise time) and maximal acceleration are two different but very useful measurements of growing interest in PAD. A background of the historical development, physics rationale, semantics, and methods of measurement, as well as their strengths and weaknesses, are discussed herein. Acceleration time is a powerful tool for predicting significant arterial stenosis or for estimating the overall impact of PAD as it is highly correlated to the ankle or toe pressure indexes. It could even become a new diagnostic criterion for critical limb ischemia. Similarly, maximal systolic acceleration ratios are highly predictive of carotid or renal stenosis. However, the literature lacks reference standards or guidelines for the assessment of such variables, and their measurement techniques seem to differ between authors. We propose herein a semantic and measurement statement order to clarify and help standardize future research.
Acuity and Quality of Vision in Eyes with Epithelial Basement Membrane Dystrophy after Regular Pseudophakia
Authors: Bellucci Carlo , Mora Paolo , Tedesco Salvatore A. , Carta Arturo , Gandolfi Stefano , Bellucci Roberto
Published: January 2023

Purpose: This retrospective case-control study was conducted to quantitatively and qualitatively assess the visual impairment in eyes with Epithelial Basement Membrane Dystrophy (EBMD) after regular cataract surgery. Methods: EBMD pseudophakic eyes were compared with matched pseudophakic eyes free from surface disorders. At least 3 weeks after surgery we evaluated uncorrected and best-corrected distance visual acuity (UDVA and CDVA), objective aberrometry, Point Spread Function (PSF), Modulation Transfer Function (MTF), and patient complaints. Results: Twenty-five EBMD eyes and 25 control eyes (13 patients per group) were included. Nine patients per group had a monofocal IOL, and four patients had a trifocal IOL. All the EBMD patients complained of postoperative blurred vision with ocular discomfort; intensive use of lubricants induced subjective improvement only in eyes with monofocal IOLs. Postoperative mean UDVA was 0.19 ± 0.16 LogMAR in the EBMD eyes and 0.11 ± 0.04 LogMAR in the control group (p = 0.016). Mean CDVA was 0.18 ± 0.15 LogMAR in the EBMD eyes and 0.06 ± 0.04 LogMAR in the control eyes (p = 0.001). The PSF curve width was significantly worse in the EBMD group (p < 0.001). The MTF cut-off value was lower in the EBMD group than in the control group (p < 0.001). Conclusion: After cataract removal, eyes with EBMD had significantly lower UDVA and CDVA than controls. All the aberrometric parameters were significantly worse in EBMD cases. EBMD patients complained about their postoperative visual outcome, while control patients did not.
Comparing the Clinical Efficacy of Coil Embolization in GDA Stump versus Common Hepatic Artery in Postoperative Hemorrhage after Pancreatoduodenectomy
Authors: Wu Chia-Chien , Chen Huan-Wu , Lee Ker-En , Wong Yon-Cheong , Ku Yi-Kang
Published: January 2023

Background: Hemorrhage after pancreaticoduodenectomy is an uncommon but fatal complication. In this retrospective study, the different treatment modalities and outcomes for treating post-pancreaticoduodenectomy hemorrhage are analyzed. Methods: Our hospital imaging database was queried to identify patients who had undergone pancreaticoduodenectomy during the period of 2004–2019. The patients were retrospectively split into three groups, according to their treatment: conservative treatment without embolization (group A: A1, negative angiography; A2, positive angiography), hepatic artery sacrifice/embolization (group B: B1, complete; B2, incomplete), and gastroduodenal artery (GDA) stump embolization (group C). Results: There were 24 patients who received angiography or transarterial embolization (TAE) treatment 37 times (cases). In group A, high re-bleeding rates (60%, 6/10 cases) were observed, with 50% (4/8 cases) for subgroup A1 and 100% (2/2 cases) for subgroup A2. In group B, the re-bleeding rates were lowest (21.1%, 4/19 cases) with 0% (0/16 cases) for subgroup B1 and 100% (4/4 cases) for subgroup B2. The rate of post-TAE complications (such as hepatic failure, infarct, and/or abscess) in group B was not low (35.3%, 6/16 patients), especially in patients with underlying liver disease, such as liver cirrhosis and post-hepatectomy (100% (3/3 patients), vs. 23.1% (3/13 patients); p = 0.036, p < 0.05). The highest rate of re-bleeding (62.5%, 5/8 cases) was observed for group C. There was a significant difference in the re-bleeding rates of subgroup B1 and group C (p = 0.00017). The more iterations of angiography, the higher the mortality rate (18.2% (2/11 patients), <3 times vs. 60% (3/5 patients), ≥3 times; p = 0.245). Conclusions: The complete sacrifice of the hepatic artery is an effective first-line treatment for pseudoaneurysm or for the rupture of the GDA stump after pancreaticoduodenectomy. Hepatic complications are not uncommon and are highly associated with underlying liver disease. Conservative treatment, the selective embolization of the GDA stump, and incomplete hepatic artery embolization do not provide enduring treatment effects.
Influencing Factors of Nurses’ Practice during the Bedside Handover: A Qualitative Evidence Synthesis Protocol
Authors: Cruchinho Paulo , Teixeira Gisela , Lucas Pedro , Gaspar Filomena
Published: January 2023

Nursing Bedside Handover (NBH) is acknowledged as a nursing practice implemented at the patient’s bedside to improve communication safety during the shift change, but it is vulnerable due to inconsistent application among nurses. This synthesis of qualitative evidence aims to review and synthesize the perceptions and experiences of nurses regarding the factors that, in their perspective, influence NBH practice. We will follow the thematic synthesis methodology of Thomas and Harden and the Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) Statement guidelines. A search will be conducted through the databases of MEDLINE, CINAHL, Web of Science, and Scopus, and we will follow the three-step search process to identify primary studies with qualitative or mixed-method research designs and projects of quality improvement. The screening and selection of the studies will be carried out by two independent reviewers. We will use the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) to report the screening, search, and selection of studies. To assess its methodological quality, two reviewers will independently use the CASM Tool. The extracted data will be reviewed, categorized, and summarized in tabular and narrative formats. The findings obtained will allow us to inform future research and change management led by nurse managers.
Planning and Designing Natural and Urban Environments with an Adaptive Visualization Framework: The Case of Pazhou Island, Guangzhou, Pearl River Delta
Authors: Tomkins Adam , Lange Eckart
Published: January 2023

In the planning and design of natural and urban environments, visualization plays an increasingly important role. It has become a core component of communication and dissemination within the various formats of project representation, environmental assessment, workshops, and stakeholder involvement in general. However, as a practical technology, the outputs of our visualizations are, too often, regarded as a static product rather than as a living and evolving tool in and of itself, often due to the inherent restrictions present in both the analog and digital technologies used in data curation and visualization creation. In this paper, we argue that with the increasing complexity and usability of digital technologies, we are now capable of bringing a heightened level of interactive dynamism to planning and design, improving the communicative power of landscape visualization. We introduce a theoretical adaptive visualization (AV) framework, designed to support project meetings and stakeholder interactions with iterative planning and design elements. To demonstrate the merits of the framework, we develop an augmented reality application following AV principles; we discuss the novel design interactions afforded by integrating alongside traditional analog and digital data sources, in an interactive and dynamic application. This is highlighted by a case study from the Pearl River Delta region, with a focus on planning and design for flood risk mitigation.
Revisiting Vegetation Gradient Analysis and the Intermediate Disturbance Hypothesis for the Interpretation of Riverine Geomorphic Patterns
Authors: Sitzia Tommaso , Iacopino Simone , Alterio Edoardo , Comiti Francesco , Surian Nicola , Mao Luca , Lenzi Mario Aristide , Campagnaro Thomas , Picco Lorenzo
Published: January 2023

Human effects on the water economy of the river systems are currently well documented at the worldwide scale, impacting a range of ecosystem services. In this perspective article, we discuss the findings of recent papers that under different intensities of human disturbance have coupled the analyses of riverine geomorphological and plant community patterns. The discussion is carried out within the historical framework of past and current methods of sampling and analysing the river geomorphology and the plant communities along cross-sectional profiles. The research has been conducted along three major gravel-bed rivers of the south-eastern Italian Alps: Brenta, Piave, and Tagliamento. The collated and summarised results here demonstrate the existence of a strong relationship between the woody species variance that can be explained by geomorphologic patterns and human disturbance intensity. The less disturbed river has an intermediate value of species variance that can be explained by geomorphology, the intermediate-disturbed river has the highest value, and the highly disturbed river has the lowest value. Then, we proposed an interpretation key and an adaptation of the intermediate disturbance hypothesis, which reads as: “in rivers, the greatest influence of geomorphic properties on vegetation occurs in the moderate or middle ranges of a human disturbance gradient”. We argue that the “influence of the geomorphic properties on vegetation” is assessed through the species constrained variance through an ordination analysis, such as that which is explained here. The most recent collection techniques based on field survey and remote sensing are making it increasingly easy and accurate to study of the trends of geomorphic and plant community variables throughout time and space. Thus, we encourage that researchers should check whether and how our observation is conserved through different groups of taxa and intensities of natural and human disturbance.
Assessment of Intra-Abdominal Pressure with a Novel Continuous Bladder Pressure Monitor—A Clinical Validation Study
Authors: Iacubovici Liat , Karol Dana , Baar Yuval , Beri Avi , Herzberg Haim , Zarour Shiri , Goren Or , Cohen Barak
Published: January 2023

Introduction: Intra-abdominal hypertension and the resulting abdominal compartment syndrome are serious complications of severely ill patients. Diagnosis requires an intra-abdominal pressure (IAP) measurement, which is currently cumbersome and underused. We aimed to test the accuracy of a novel continuous IAP monitor. Methods: Adults having laparoscopic surgery and requiring urinary catheter intra-operatively were recruited to this single-arm validation study. IAP measurements using the novel monitor and a gold-standard foley manometer were compared. After anesthesia induction, a pneumoperitoneum was induced through a laparoscopic insufflator, and five randomly pre-defined pressures (between 5 and 25 mmHg) were achieved and simultaneously measured via both methods in each participant. Measurements were compared using Bland–Altman analysis. Results: In total, 29 participants completed the study and provided 144 distinct pairs of pressure measurements that were analyzed. A positive correlation between the two methods was found (R2 = 0.93). There was good agreement between the methods, with a mean bias (95% CI) of −0.4 (−0.6, −0.1) mmHg and a standard deviation of 1.3 mmHg, which was statistically significant but of no clinical importance. The limits of agreement (where 95% of the differences are expected to fall) were −2.9 and 2.2 mmHg. The proportional error was statistically insignificant (p = 0.85), suggesting a constant agreement between the methods across the range of values tested. The percentage error was 10.7%. Conclusions: Continuous IAP measurements using the novel monitor performed well in the clinical setup of controlled intra-abdominal hypertension across the evaluated range of pressures. Further studies should expand the range to more pathological values.
Consequences of Real-World Surveillance of Fellow Eyes in Neovascular Age-Related Macular Degeneration
Authors: Onwuka Oluchukwu , Saddemi Jackson L. , Akkan Aydoğmuş Fatma Sema , Lasalle Claudia C. , Ramsey David J.
Published: January 2023

This study investigated whether the interval of monitoring at-risk, fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD) has any bearing on the severity of the disease at the time of diagnosis. The study comprised a retrospective, cross-sectional comparative case series of treatment-naïve eyes in patients who were diagnosed sequentially with nAMD. We compared the visual acuity (VA) and central macular thickness (CMT) of patients who were actively receiving intravitreal injections (IVIs) of anti-vascular endothelial growth factor (anti-VEGF) agents at the time of second eye diagnosis with the VA and CMT of patients who had ceased treatment in their first eye because of reaching end-stages of disease. Intervals of visits and frequency of monitoring the macula of fellow eyes by means of optical coherence tomography (OCT) were abstracted from the medical record. We found that the at-risk fellow eyes of patients who had stopped treatment for nAMD in their first eye prior to fellow eye conversion were monitored significantly less frequently than the fellow eyes of patients who continued to receive treatment at the time of second eye diagnosis. Despite less frequent monitoring, VA and CMT were similar at the time of fellow eye diagnosis for both groups.
Effect of Tempforming on Strength and Toughness of Medium-Carbon Low-Alloy Steel
Authors: Yuzbekova Diana , Dudko Valeriy , Pydrin Alexander , Gaidar Sergey , Mironov Sergey , Kaibyshev Rustam
Published: January 2023

The effect of tempforming on the strength and fracture toughness of 0.4%C-2%Si-1%Cr-1%Mo-VNb steel was examined. Plate rolling followed by tempering at the same temperature of 600 °C increases yield stress by 25% and the Charpy V-notch impact energy by a factor of ~10. Increasing rolling reduction leads to the reorientation and elongation of grains toward the rolling direction (RD) and the development of a strong {001} <110> (rotated cube) texture component that highly enhances fracture toughness. A lamellar structure with a spacing of 72 nm between boundaries and a lattice dislocation density of ~1015 m−2 evolves after tempforming at 600 °C with a total strain of 1.4. Two types of delamination were found, attributed to crack branching and the propagation of secondary cracks along the rolling plane perpendicular to the propagation direction of the primary crack. Delamination toughness is associated with the nucleation of secondary cracks in RD and their propagation over a large distance. The critical condition for delamination toughness is the propagation of primary cracks by the ductile fracture mechanism and the propagation of secondary cracks by the brittle quasi-cleavage mechanism.
Robust Online Support Vector Regression with Truncated ε-Insensitive Pinball Loss
Authors: Shan Xian , Zhang Zheshuo , Li Xiaoying , Xie Yu , You Jinyu
Published: January 2023

Advances in information technology have led to the proliferation of data in the fields of finance, energy, and economics. Unforeseen elements can cause data to be contaminated by noise and outliers. In this study, a robust online support vector regression algorithm based on a non-convex asymmetric loss function is developed to handle the regression of noisy dynamic data streams. Inspired by pinball loss, a truncated ε-insensitive pinball loss (TIPL) is proposed to solve the problems caused by heavy noise and outliers. A TIPL-based online support vector regression algorithm (TIPOSVR) is constructed under the regularization framework, and the online gradient descent algorithm is implemented to execute it. Experiments are performed using synthetic datasets, UCI datasets, and real datasets. The results of the investigation show that in the majority of cases, the proposed algorithm is comparable, or even superior, to the comparison algorithms in terms of accuracy and robustness on datasets with different types of noise.
Methods for Fungicide Efficacy Screenings: Multiwell Testing Procedures for the Oomycetes Phytophthora infestans and Pythium ultimum
Authors: Marcianò Demetrio , Toffolatti Silvia Laura
Published: January 2023

Oomycetes-borne diseases represent a serious problem for agriculture sustainability due to the high use of chemical products employed for their control. In recent years, increasing concerns on side effects associated with fungicide utilization have led to the reduction of the permissible modes of action, with the remaining ones continuously threatened by the increase of resistant strains in the pathogen populations. In this context, it is mandatory to develop new generation fungicides characterized by high specificity towards the target species and low environmental impact to guarantee the sustainability, productivity, and quality of food production. Fungicide discovery is a lengthy and costly process, and despite these urgent needs, poor description and formalization of high-throughput methodologies for screening the efficacy of active compounds are commonly reported for these kinds of organisms. In this study, a comprehensive picture of two high-throughput practices for efficient fungicide screening against plant-pathogenic oomycetes has been provided. Different protocols using multiwell plates were validated on approved crop protection products using Phytophthora infestans and Pythium ultimum as the model species. In addition, detailed statistical inputs useful for the analysis of data related to the efficacy of screenings are included.
The Functional Roles of ISG15/ISGylation in Cancer
Authors: Yuan Yin , Qin Hai , Li Huilong , Shi Wanjin , Bao Lichen , Xu Shengtao , Yin Jun , Zheng Lufeng
Published: January 2023

The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified member of the ubiquitin-like protein family and exists in the form of monomers and conjugated complexes. Like ubiquitin, ISG15 can mediate an ubiquitin-like modification by covalently modifying other proteins, known as ISGylation. There is growing evidence showing that both the free and conjugated ISG15 are involved in multiple key cellular processes, including autophagy, exosome secretion, DNA repair, immune regulation, and cancer occurrence and progression. In this review, we aim to further clarify the function of ISG15 and ISGylation in cancer, demonstrate the important relationship between ISG15/ISGylation and cancer, and emphasize new insights into the different roles of ISG15/ISGylation in cancer progression. This review may contribute to therapeutic intervention in cancer. However, due to the limitations of current research, the regulation of ISG15/ISGylation on cancer progression is not completely clear, thus further comprehensive and sufficient correlation studies are still needed.
Charge Asymmetry of Muons Generated in a Muon Generator from Ultra-Dense Hydrogen D(0) and p(0)
Authors: Holmlid Leif
Published: January 2023

Laser-induced nuclear reactions in ultra-dense hydrogen H(0) (review in Physica Scripta 2019) create mesons (kaons and pions). These mesons decay mainly to muons. The muons created are useful (patented source) for the muon-induced fusion process. The sign of the muons from the source depends on the initial baryons used. With D(0) (ultra-dense deuterium) the source produces mainly positive muons and with p(0) (ultra-dense protium) the source produces mainly negative muons. Negative muons are required for muon-induced fusion. This charge asymmetry was reported earlier, and has now been confirmed by experiments with a coil current transformer as the beam detector. The current coil detector would give no signal from the muons if charge symmetry existed. The charge asymmetry could indicate unknown processes, for example, caused by the different annihilation processes in D(0) and p(0). The conclusions of a new analysis of the results are presented here. Using D(0) in the muon source, the asymmetry is likely due to the capture of µ- in D atoms and D2 molecules. This leads to emission of excess µ+ from D(0). With p(0) in the muon source, the capture rate of µ- is lower than in D(0). The emitted number of µ+ will be decreased by the reaction between µ+ and the surrounding abundant electrons, forming neutral muonium particles. This effect decreases the amount of emitted µ+ for both p(0) and D(0), and it is proposed to be the main reason for a larger fraction of emitted µ- in the case of p(0). Thus, there is no dominant emission of negative muons which would violate charge conservation.
Pharmacists’ Experiences, Perceptions, and Attitudes towards Suicide and Suicide Prevention: A Scoping Review
Authors: Kamal Lujain , Jacob Sabrina Anne
Published: January 2023

It is important to understand pharmacists’ experiences, stigmas, trainings, and attitudes to suicide, as they can affect the way pharmacists interact with at-risk individuals and influence outcomes. The aim of this scoping review is to explore pharmacists’ willingness, experiences, and attitudes towards suicide prevention, as well as to examine the impact of suicide prevention training programs. A systemic search was conducted using the following databases: PubMed, EMBASE, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. Studies included were from database inception to 31 August 2022, in English, with full-text available. A total of 13 studies were included. Training was a key factor which had an impact on pharmacists’ attitudes, experiences, and preparedness to participate in suicide care, with studies revealing the lack of training and the call for more training by pharmacists. Another key factor was closeness to mental illness, which also impacted pharmacists’ attitudes and experiences with at-risk patients. More research is needed worldwide to understand the different barriers and facilitators to pharmacist involvement in suicide care. Targeted training programs should also be developed to not only increase knowledge and competence, but also to address stigma related to suicide.
Active Polarization Imaging for Cross-Linear Image Histogram Equalization and Noise Suppression in Highly Turbid Water
Authors: Zhang Huajun , Gong Jianrui , Ren Mingyuan , Zhou Ning , Wang Hantao , Meng Qingguo , Zhang Yu
Published: January 2023

The absorption and scattering of impurity particles in turbid water cause the target signal light to be attenuated and to produce backscattered light, resulting in the reduced quality of underwater polarimetric imaging. As water turbidity increases, the effect of backscattered light becomes greater, making polarization imaging in highly turbid water a challenge. Theory and experiment show that the increase in the intensity of backscattered light leads to high noise gain in the underwater active polarization imaging model. In order to enhance image contrast and suppress noise gain in highly turbid water, we propose an underwater imaging enhancement method that appropriately combines the non-physical and physical models. The method uses contrast limited adaptive histogram equalization (CLAHE) for a certain number of cross-linear images (Imin) before calculating their polarization enhancement images, and it constructs joint filtering (multi-frame averaging and bilateral filtering) to suppress the high noise gain introduced by the imaging model and CLAHE. The experimental results in highly turbid water validate the rationality and feasibility of the proposed method, and the comparative processing results (52.7~98.6 NTU) outperform those of the conventional non-physical and physical model methods. The method maintains the complexity of the system and facilitates the application of conventional polarimetric imaging in harsher underwater environments.
Kinetics of Micellization and Liquid–Liquid Phase Separation in Dilute Block Copolymer Solutions
Authors: Sato Takahiro
Published: January 2023

A lattice theory for block copolymer solutions near the boundary between the micellization and liquid–liquid phase separation regions proposes a new kinetic process of micellization where small concentrated-phase droplets are first formed and then transformed into micelles in the early stage of micellization. Moreover, the thermodynamically stable concentrated phase formed from metastable micelles by a unique ripening process in the late stage of phase separation, where the growing concentrated-phase droplet size is proportional to the square root of the time.
Creep Analysis of Bamboo Composite for Structural Applications
Authors: Zanker Hayden , Rajabipour Ali , Huang Dongsheng , Bazli Milad , Tang Siyuan , Cui Zhaoyan , Zhu Jia , Kennaway Joel , Diaz Luis
Published: January 2023

The present study investigates the phenomena of creep in a bamboo composite. The material was tested under tensile and compressive loading and simulated in finite element analysis software to estimate the creep coefficients. The presented findings have displayed the material’s propensity to fail at loads lower than the recorded ultimate strength, as early as 65% of this strength within 100 h, showing the importance of considering creep when designing structural components. Larger resistance to creep was observed under tensile stresses. Coefficients of the time-hardening creep model were estimated, which were found to be different under compression and tension. The findings provide insight into the reliable strength value of the Bamboo Composite. They could be also essential in estimating the long-term deflations in Bamboo Composite structures.
Evaluation of the Processing of Multi-Crop Plants into Pelletized Biofuel and Its Use for Energy Conversion
Authors: Petlickaitė Rita , Jasinskas Algirdas , Domeika Rolandas , Pedišius Nerijus , Lemanas Egidijus , Praspaliauskas Marius , Kukharets Savelii
Published: January 2023

Multi-crop plants (fibrous hemp, maize, and faba bean) can potentially be an alternative to wood biomass pellets, but there is no detailed knowledge to support the suitability of this biomass for solid biofuel production. The aim of this study is to analyze and justify the suitability of multi-crop plant biomass for the production of biofuel pellets and to assess the environmental impact of burning them. This paper presents studies of physical-mechanical, thermal, and chemical characteristics of biofuel pellets from multi-crop plants and emissions during their combustion under laboratory conditions. The main parameters of the produced pellets were determined according to international standards, which are detailed in the methodology part. The length of the produced pellets ranged from 17.6 to 26.6 mm, and the diameter was about 6 mm. The density of wet pellets varied from 1077.67 to 1249.78 kg m−3. The amount of ash in the pellets varied from 5.75% to 8.02%. Determined lower calorific value of all pellets was close to 17.1 MJ kg−1. The lowest CO and CxHy emissions were determined when burning MIX2-1 pellets (biomass of the binary crop); their values were 572 and 29 ppm, respectively. The lowest content of CO2 was determined when burning S-Mz pellets (mono crop biomass), and it was 3.5%. The lowest NOx emissions were also determined when burning the pellets of this sample, with a value of 124 ppm. Research results show that multi-crop plants are a suitable raw material for the production of solid biofuel, the burning of which does not cause negative consequences for the environment.
Rehydration Activity of High-Temperature Calcined Recycled Sand Autoclaved Aerated Concrete
Authors: Yang Xiuli , Zhu Renmiao , Xu Bin
Published: January 2023

Autoclaved aerated concrete is an excellent thermal insulation wall material, but with a large amount of waste. This paper describes the high-temperature activation and rehydration activity of waste cement–lime–sand autoclaved aerated concrete (SAAC) and discusses the high-temperature phase transition of SAAC. SAAC calcined at 750 °C was confirmed to be a metastable and amorphous state, which could hydrolyze Ca2+ ions with reactivity in water. The conductivity curve demonstrates that the concentration of ions in the suspension decreases rapidly at 150–250 min, and the hydration reaction turns dominant at this time. The hydration heat curve also displays a hydration exothermic peak at 2.5 h. In addition, the conductivity measurement of suspension and the exothermic measurement of hydration reaction proves that SAAC calcined at 750 °C has a hydration activity and can rehydrate with SiO2 in the system. The rehydration activity was verified by replacing 30% cement in the standard test block with calcined SAAC because the calcined SAAC at 750 °C has high hydration activity, and its activity index reached 89.58%. Fly ash is a commonly used cement admixture at present. Hence, the SAAC calcined at 750 °C and the fly ash were used to replace 30% of the cement in the cement test block, respectively. The results of this comparative experiment vividly showed that the reaction activity of SAAC calcined at 750 °C was higher than that of fly ash. Therefore, according to this research, SAAC has activity after calcination at 750 °C and can be hydrated again.
An Unexpected 12.6 Centimeter Nail in the Thorax Damaging Vital Structures: A Case Report “Nailed It”
Authors: Avedissian Thomas H. , Thuijs Daniel J. F. M. , Timmermans Lucas , Maat Alexander P. W. M. , Mahtab Edris A. F.
Published: January 2023

We report a patient who was referred to the emergency room with pulmonary complaints and where a computed tomography (CT) scan showed an unexpected 12.6 cm nail in the thorax penetrating part of the left pulmonary upper lobe, the left pulmonary artery, the left main bronchus, and the descending aorta, which had been in situ for at least three days. The quickly deteriorating patient had to be transferred to a tertiary academic hospital where the nail was successfully surgically removed. The comprehensive description of this unique case with a discussion of the critical decision moments could render insights into the management of challenging trauma cases.
Investigation of the Effects of Monosodium Glutamate on the Embryonic Development of the Eye in Chickens
Authors: Bölükbaş Ferhan , Öznurlu Yasemin
Published: January 2023

MSG is the most ubiquitous food additive in the food industry. The aim of this report was to investigate the effects of in ovo MSG administration on embryonic chicken eye development using histological and histometric methods. A total of 410 fertilized eggs obtained from Babcock Brown laying hens (Gallus gallus domesticus) were used and divided into 5 groups: I (untreated control), II (vehicle control), III (0.12 mg/g egg MSG), IV (0.6 mg/g egg MSG), and V (1.2 mg/g egg MSG), and injections were performed via the egg yolk. At incubation day 15, 18, and 21, 6 embryos from each group were sacrificed by decapitation and pieces of eye tissue were obtained. In all MSG groups, it was determined that both corneal epithelium thickness and total corneal thickness decreased at incubation time points 15, 18, and 21 days compared with the controls (p < 0.05). The total retinal thickness, thickness of the outer nuclear layer (ONL), inner nuclear layer (INL), ganglion cell layer (GL), and nerve fibre layers (NFL), as well as the number of ganglion cells decreased significantly at incubation days 15, 18, and 21 (p < 0.05), and degenerative changes such as vacuolar degeneration and retinal pigment epithelial detachment were also observed. In conclusion, MSG in ovo administration can affect the cornea and distinct layers of retinal cells.
Behavior of Control and Inhibitive Polyaspartic Coatings Using Alkylammonium and Zinc Phosphate Corrosion Inhibitors in Soil
Authors: Elhoud Abdu , Van Everbroeck Tim
Published: January 2023

This study is part of an anti-corrosion coating development project at CHEMSYSTEMS. The corrosion performance was assessed through erosion, immersion and soil corrosion experiments. The erosion results have previously been published. This article discusses the impact of soil on control polyaspartic coatings used to protect concrete and the modified polyaspartic coating intended to protect underground steel substrates. The modified polyaspartic coating was boosted with a micaceous iron oxide barrier, a liquid alkylammonium corrosion inhibitor, a powdered zinc phosphate corrosion inhibitor and a novel hardener. The surface finish of the steel samples was of a milled and blasted nature (SA 2.5). The coating was applied directly to the metal without the application of a primer or second layer of coating. The average thickness of the coating was 220±10 µm as a direct-to-metal protection system. The experiments were conducted in soil at room temperature (RT) and 35°C over 30 days. The experimental results of the control polyaspartic coating loaded on steel substrates exhibited severe blistering. The polyaspartic coating dispersed with a liquid alkylammonium inhibitor also exhibited blistering, whereas the modified polyaspartic coating with a zinc phosphate corrosion inhibitor showed an adequate degree of resistance to the impact of soil under the evaluated conditions. The results confirmed that the presence of a zinc phosphate corrosion inhibitor in combination with a micaceous iron oxide barrier improved the resistance of the coating to the evaluated soils in which it was positioned and at the investigated temperatures.
Joint and soft tissue injections in Irish primary care: a survey of GPs’ attitudes and practices
Authors: Farrell James , Cullen Walter , Broughan John
Published: January 2023

Background

Musculoskeletal conditions are common in primary care, causing significant morbidity. Intra-articular and soft tissue corticosteroid injections are commonly performed by GPs internationally. It is unknown how commonly they are performed by GPs in the Republic of Ireland.

Aim

To determine the frequency and type of joint and soft tissue injections performed by GPs in the Republic of Ireland and investigate factors affecting their use.

Design & setting

A cross-sectional online questionnaire, which was based on previous international research, was devised for completion by GPs practising in the Republic of Ireland.

Method

GPs were invited to electronically complete a questionnaire on their practices and attitudes regarding joint and soft tissue injections.

Results

A total of 147 of 204 GPs (72.1%) had performed an intra-articular or soft tissue injection in the preceding year. GPs who were principals or partners, male, or worked in a rural or mixed urban and rural practice setting were more likely to perform these procedures. The most common injection sites were the shoulder and knee. Participants were confident about performing joint and soft tissue injections. It was found that 80.4% had received prior training in this treatment modality, most commonly during their GP training programme. A prolonged wait for secondary care intervention, symptom duration, and symptom severity were factors that increased the likelihood of performing injections. Difficulty maintaining skills and medicolegal concerns were common barriers to performing joint and soft tissue injections.

Conclusion

Most GPs surveyed carried out joint and soft tissue injections, most commonly injecting the shoulder and knee. Irish GPs experience many of the same barriers to performing intra-articular injection as experienced internationally.
Re-examining advice to complete antibiotic courses: a qualitative study with clinicians and patients
Authors: Borek Aleksandra J , Edwards George , Santillo Marta , Wanat Marta , Glogowska Margaret , Butler Christopher C , Walker Ann Sarah , Hayward Gail , Tonkin-Crine Sarah
Published: January 2023

Background

Antibiotic treatment duration may be longer than sometimes needed. Stopping antibiotics early, rather than completing pre-set antibiotic courses, may help reduce unnecessary exposure to antibiotics and antimicrobial resistance (AMR).

Aim

To identify clinicians' and patients' views on stopping antibiotics when better (SAWB) for urinary tract infections (UTIs), and to explore comparisons with other acute infections.

Design & setting

An exploratory qualitative study with general practice clinicians and patients in England.

Method

Primary care clinicians and patients who had recent UTI experience were recruited in England. Remote one-to-one interviews with clinicians and patients, and one focus group with patients, were conducted. Data were audiorecorded, transcribed, and analysed thematically.

Results

Eleven clinicians (seven GPs) and 19 patients (14 with experience of recurrent and/or chronic UTIs) were included. All participants considered SAWB unfamiliar and contradictory to well-known advice to complete antibiotic courses, but were interested in the evidence for risks and benefits of SAWB. Clinicians were amenable if evidence and guidelines supported it, whereas patients were more averse because of concerns about the risk of UTI recurrence and/or complications and AMR. Participants viewed SAWB as potentially more appropriate for longer antibiotic courses and other infections (with longer courses and lower risk of recurrence and/or complications). Participants stressed the need for unambiguous advice and SAWB as part of shared decision making and personalised advice.

Conclusion

Patients were less accepting of SAWB, whereas clinicians were more amenable to it. Patients and clinicians require good evidence that this novel approach to self-determining antibiotic duration is safe and beneficial. If evidence based, SAWB should be offered with an explanation of why the advice differs from the ‘complete the course’ instruction, and a clear indication of when exactly to stop antibiotics should be given.