bluuebunny/crossref_metadata_2025 huggingface dataset:
РОЗРОБЛЕННЯ КОМП’ЮТЕРНОЇ ГРИ З ГОЛОСОВИМ ІНТЕРФЕЙСОМ ДЛЯ ВИВЧЕННЯ АНГЛІЙСЬКОЇ МОВИ ДІТЬМИ ДОШКІЛЬНОГО ВІКУ
Authors: Федусенко Олена Володимирівна , Доманецька Ірина Миколаївна , Семенюк Дар’я Юріївна
Published: November 2021

Стаття присвячена питанням гейміфікації дошкільної освіти, а саме застосуванню комп’ютерних ігор для вивчення іноземної мови. Більшість застосунків для вивчення англійської мови, що існують на цей час, орієнтовані на дітей більш старшого віку та мають стандартний інтерфейс взаємодії з користувачем. Авторами запропоновано використання інтелектуального інтерфейсу, який базується на методах розпізнання голосу, а саме на методах розпізнавання мовлення на основі обмеженого словника та граматики запитів. У статті наведено повний цикл розробки комп’ютерної гри: спочатку було проведено аналіз та визначення вимог до гри, далі була побудована архітектура, після чого розроблено програмне забезпечення та проведено його тестування. Для проєктування гри було використано сучасний архітектурний фреймворк TOGAF (The Open Group Archіtecture Framework) та відповідний інструмент візуального моделювання Archimate. Такий підхід дозволив авторам визначити вимоги до гри, що базуються на основних цілях та проблемах стейкхолдерів; провести аналіз основних бізнес-процесів гри, зокрема процес роботи з голосовим інтерфейсом, як з точки зору розробника, так і гравця; спроєктувати архітектуру комп’ютерної гри. Для програмної реалізації гри авторами було обрано платформу Unity, а для реалізації голосового інтерфейсу один з класів модулю UnityEngine.Windows.Speech. Наведено приклад роботи одного з рівнів гри, який призначено для вивчення назв фруктів та закріплення знання назв кольорів англійською мовою. Останнім етапом проєктування будь-якої інформаційної системи є тестування, авторами розроблено тест-кейс для тестування одного з рівнів комп’ютерної гри. Даний тест-кейс охоплює усі кроки, які робить гравець під час гри, та доводить коректність роботи як програмного застосунку в цілому, так і окремо голосового інтерфейсу. Розроблена авторами гра дозволить підвищити ефективність та якість вивчення англійської мови дітьми дошкільного віку шляхом збільшення їх зацікавленості та спрощення процесу навчання.
EXAMINATION OF TEACHERS' EXPERIENCES IN THE EMERGENCY DISTANCE EDUCATION PERIOD
Authors: Tatlı Ayşenur , Eryilmaz Selami
Published: November 2021

The Covid 19 virus epidemic, which is the greatest danger of the 21st century, has significantly affected the way of life in the world. Scientists do their best to prevent the epidemic. They emphasize that the trio of mask, distance and cleaning will be sufficient. The epidemic, which emerged in China and negatively affected almost all countries in the world in almost every field, has also adversely affected the field of education. The education and training process in schools was suspended temporarily. Due to reasons such as the epidemic could not be stopped and prevented, starting from March 2020, some countries decided to continue their education in distance education environments in order to prevent children and young people from being harmed in their education and training processes. With the rapid transition to the distance education process, almost the entire education process has entered the digitalization process. The biggest share behind the management of the process called “emergency distance education” belongs to teachers. Teachers also use digital media in this process. They changed the way of communication with the students, their teaching methods, and the materials they used. Teachers are in the global epidemic process, they took part in the forefront of education to continue. Although they were caught unprepared for the situation, they carried out various studies to make the process effective. During this period, various concerns and expectations arose among the teachers, who always made an effort, in terms of using technology. With this research, the attitudes of teachers towards distance education, the problems teachers experience during this period, and accordingly the development of their technology use skills and the current situation in evaluating the process in educational environments have been revealed. This study, which was conducted by taking the opinions of the teachers who work in Ankara and selected by random sampling method, is in the case study design, one of the qualitative research methods. The data obtained from the teachers were analyzed by content analysis method. In general, the teachers who participated in the study shared the situations they experienced during this process.
РОЛЬ ЦИФРОВИХ ТЕХНОЛОГІЙ У ФОРМУВАННІ ПОЧУТТЯ ВЛАСНОСТІ МОЛОДОГО ВЧЕНОГО
Authors: Губеладзе Ірина Гурамівна , Яцишин Анна Володимирівна , Сухіх Аліса Сергіївна
Published: November 2021

Застосування цифрових технологій суттєво змінило специфіку науково-дослідної діяльності. Підвищення власної цифрової компетентності є важливим для наукових і науково-педагогічних працівників, аспірантів та докторантів, оскільки саме вони здійснюють наукові дослідження і популяризують науку серед широкої громадськості. Нині цифрові технології є ефективним засобом не тільки для проведення, представлення і впровадження результатів наукових досліджень у практику, а й для формування у молодого вченого відчуття спільності з науковою спільнотою своєї установи, країни і світу загалом, почуття власності та створення власного наукового продукту. Під почуттям власності ми розуміємо суб’єктивне емоційне переживання людини щодо належності їй певних об’єктів власності, що відображає зміст та значення, яке мають для неї реальні або абстрактні, конкретні або узагальнені об’єкти власності, тобто все те, що може назвати своїм («мою установу», «моє робоче місце», «моя наукова праця», «мої матеріали»). Представлено результати емпіричного дослідження, які підтвердили позитивний взаємозв’язок між рівнем прояву почуття власності, рівнем задоволеності науковою діяльністю, психологічним благополуччям і відчуттям ефективності й потрібності власної наукової діяльності. Розроблено рекомендації для формування почуття власності серед аспірантів і молодих учених і посилення його із застосуванням цифрових технологій. Запропоновано та обґрунтовано перелік цифрових технології, що доцільно застосовувати для формування почуття власності молодих учених, зокрема сайт установи, сторінки в соціальних мережах: Facebook, Instagram, канал YouTube, е-пошта, Google Форм, Telegram, Viber, Google Meet, Zoom, Microsoft Teams та ін. Наголошено на важливості застосування цифрових технологій для формування почуття власності аспірантів і молодих учених. Визначено, що створення системи соціально-психологічного супроводу аспіранта і молодого ученого для входження в наукове середовище позитивно позначиться на рівні психологічного благополуччя молодих дослідників та на забезпеченні можливостей побудови ними успішної наукової кар’єри та підвищенні відчуття життєвої успішності.
Obtenção da farinha do resíduo do processamento de acerola e avaliação de compostos bioativos e nutritivos
Authors: Magalhães Marcela Paula Drumond , Gandra Kelly Moreira Bezerra , Cunha Luciana Rodrigues da , Lima Emília Maria França
Published: November 2021

A acerola é uma fruta de grande valor nutricional reconhecida pelo elevado teor de vitamina C, e possui variada aplicabilidade na indústria de alimentos. O seu processamento gera uma quantidade considerável de resíduos, e há carência de informações sobre a composição e o aproveitamento deste material. Diante do exposto, o objetivo desse estudo foi produzir uma farinha a partir do resíduo do despolpamento da acerola, e realizar a caracterização físico-química e análise de compostos bioativos, visando um possível aproveitamento para fins alimentícios. A farinha, constituída de semente e casca da fruta, mostrou-se um subproduto rico nutricionalmente, contendo 9,12% de proteína, 3,40% de lipídios, 1,76% de cinzas, 6,64% de umidade e 79,07% carboidratos, pH de 3,23 e acidez titulável de 3,30 g ácido cítrico/100g. Quanto aos compostos bioativos, a farinha apresentou elevados teores de vitamina C (764,40 mg/100 g), carotenoides (23,93 µg/g), compostos fenólicos totais (28,46 mg AGE/100 g), atividade antioxidante pelo radical DPPH (EC50 113,40 g de farinha/g DPPH) e ABTS (193,90 μmol/g de farinha). A farinha desenvolvida apresentou-se como alternativa de aproveitamento para fins alimentícios, com boa conservação devido ao baixo teor de água, além de contribuir para a redução dos resíduos agroindustriais.
O impacto na qualidade de vida nos indivíduos pós Covid-19: O que mudou?
Authors: Carvalho Mylla Crislley Trindade , Jesus Bruna Maria Barros de , Castro Vinicius Leite de , Trindade Leda Maria Delmondes
Published: November 2021

Objetivos: Avaliar a qualidade de vida relacionada à saúde dos pacientes acometidos pelo Covid -19, através do instrumento SF-36. Métodos: Estudo transversal e observacional realizado entre os meses de janeiro e agosto de 2021. A amostra foi constituída por 221 participantes, com base na aplicação do questionário SF-36, avaliando-se a qualidade de vida em oito domínios naqueles pacientes atendidos pelo Instituto de Promoção e de Assistência à Saúde de Servidores do Estado de Sergipe – IPESAÚDE, diagnosticados com o Covid-19 mediante teste RT-PCR positivo e que tenham sido cadastrados e acompanhados pelo projeto “Monitora Corona”. O nível de significância estatística adotado foi de 0,05 e o software utilizado o R Core Team 2021. Resultados: Um total de 221 pacientes foram incluídos no estudo. Destes, 63,8% eram do sexo feminino, com idade média de 43,6 anos. Os domínios apontaram os determinados valores: Capacidade Funcional - 68,5 DP (desvio-padrão); Limitação por Aspectos Físicos - 48,9 DP; Dor - 55,5 DP; Estado Geral de Saúde - 54,9 DP; Vitalidade - 50,5 DP; Aspectos Sociais - 53,5 DP; Limitação por Aspectos Emocionais - 43,4 DP; Saúde Mental - 54,3 DP. Considerações finais: Na amostra avaliada, a maioria dos pacientes foram constituidos por mulheres adultas jovens com a qualidade de vida e saúde mental significativamente alteradas pela infecção pelo SARS-CoV-2 e seu tratamento. Diante o exposto, sugere-se necessidade de enfrentamento das repercussões negativas da saúde mental com propostas de organização e implementação de serviços de atenção à saúde da população.
Perfil microbiológico e alterações citológicas associadas as amostras cérvico-vaginais coletadas em uma instituição filantrópica no estado de Sergipe
Authors: Resende Angelina Freire , Pinto Douglas Santos , Silva Edclécia Santos , Santos Rafaela Windy Farias dos , Almeida Patrícia de Oliveira Santos
Published: November 2021

O câncer de colo uterino é um problema de saúde pública, sendo o terceiro tipo de câncer mais comum em mulheres no Brasil, podendo ser diagnosticado através do exame citopatológico. O objetivo do trabalho é analisar o perfil microbiológico e alterações citológicas associadas as amostras cérvico-vaginais coletadas em uma instituição filantrópica, no estado de Sergipe. Trata-se de uma pesquisa retrospectiva, descritiva e transversal, em que foram analisados os resultados dos prontuários de mulheres que realizaram o exame citopátológico entre os meses de julho à outubro de 2017. No período de estudo, foram realizados 500 exames citopatológicos, sendo que 96% (480/500) das amostras foram consideradas satisfatórias e 4% (20/500) insatisfatórias. Ao analisar o perfil microbiológico, notou-se: Microbiota Mista em 31,2% (156/500) dos casos, Cocos em 29,45 (147/500), Lactobacilos sem citólise em 16% (80/500), Lactobacilos com citólise em 9,2% (46/500), Bacilos supracitoplasmáticos em 7,4% (37/500), Cocobacilos em 1,6% (8/500), Cândida spp. em 2,4% (12/500), Trichomonas vaginalis em 0,8% (4/500) e ausência de microorganismos em 1,6%. Já os achados citológicos foram representados da seguinte forma: Inflamação em 73,6% (368/500) dos casos, Dupla Alteração, ou seja, Atrofia com Inflamação e Metaplasia Escamosa Imatura e/ou Inflamação com Metaplasia Escamosa imatura 13,4% (64/500) dos casos, Atrofia com Inflamação em 9,4% (47/500), dentro dos limites da Normalidade em 3,4% (17/500) e Metaplasia Escamosa Imatura em 1% (5/500) dos resultados. Portanto, o número de microorganismos encontrados nos resultados foram elevados. Em relação as alterações citológicas, foi observado que a inflamação estava presente na maioria dos casos.
Transtorno de Déficit de Atenção/Hiperatividade, Legislação, Escola e PAE – Breve análise
Authors: Carvalho Aline dos Santos Moreira de , Pereira Pedro Carlos , Oliveira Marta Martins de
Published: November 2021

O Transtorno de Déficit de Atenção e Hiperatividade é um transtorno a nível neurocomportamental que apresenta consequências para a aprendizagem. Todavia, não está compreendido como necessidade educacional especial. Sendo assim, o presente estudo justifica-se pela necessidade de analisar o apoio dado aos alunos com TDAH, na rede municipal de ensino no município de Saquarema, Estado do Rio de Janeiro, esclarecendo acerca do transtorno, pontuando a legislação que versa sobre o tema, o apoio oferecido pelo município aos educandos portadores de TDAH bem como sua eficácia relacionada ao Índice de Desenvolvimento da Educação Básica (IDEB). Para tal utilizou-se pesquisa de caráter descritivo na Escola Municipal Edilson Vignoli Marins assim como de revisão literária em publicações, periódicos, trabalhos acadêmicos e artigos acerca do tema e de seus aspectos relevantes, utilizando a palavras-chave como educação, IDEB, Programa de Apoio ao Educando (PAE), Saquarema, TDAH, selecionados em bases de dados como Pubmed, Scielo, Google Scholar, bibliotecas virtuais, entre outras, como corte de tempo de onze anos (2008 a 2019). Os resultados obtidos foram expostos em subtítulos, pelos quais foram expostos conceitos e características gerais do transtorno bem como seu histórico como tal; a legislação que versa sobre o tema e/ou ausência dessa; a cidade de Saquarema, sua política pública educacional para enfrentamento da questão (Programa de Apoio ao Educando – PAE) e a eficácia desse registrada pelo IDEB e a pesquisa descritiva sobre a Escola Municipal Edilson Vignoli Martins, um dos polos do PAE. Por fim, foram apresentadas as considerações finais acerca do estudo.
O sofrimento da pessoa gorda na busca de cuidados à saúde: relatos de um ativista do Youtube contra gordofobia
Authors: Silva Claudia Valéria Cardim da , Deslandes Suely Ferreira
Published: November 2021

O debate sobre a gordofobia e seus enfrentamentos vem crescendo no Brasil, reunindo milhões de seguidores em diferentes plataformas. O objetivo deste trabalho foi analisar os discursos do ciberativismo gordo, por meio da análise de narrativas relativas à alimentação e às relações com trabalhadores e serviços de saúde. Metodologia: Trata-se de um estudo qualitativo no YouTube, realizado por meio do canal “Bernardo Fala”. A análise de argumentos, na perspectiva de Toulmin, foi adotada como método de compreensão das estruturas argumentativas utilizadas pelo YouTuber. Resultados: As principais teses identificadas pontuam o peso enquanto preditor insuficiente da saúde, os malefícios das dietas, e o constrangimento sofrido pela pessoa gorda no cuidado à saúde. Conclusão: O trabalho evidenciou, nas estruturas de argumentação, um debate comum sobre o ciberativismo gordo que converge para a necessidade de investimentos na educação e formação dos trabalhadores da saúde e nas estruturas de atenção à saúde da pessoa gorda.
Famílias e adoções: um estudo bibliográfico
Authors: Anjos Djaniffer dos , Iop Michela
Published: November 2021

Pais/cuidadores suficientemente bons favorecem o desenvolvimento emocional saudável – a curto, médio e longo prazo - de seus filhos, assim, é interessante pensar nos sujeitos carentes destas figuras e que ficam à mercê da adoção. O objetivo geral é responder como se caracterizam as pesquisas sobre família e adoção, os específicos buscam identificar as configurações familiares estudadas neste contexto, elencar as subáreas de conhecimento que estudaram esta interface e listar as contribuições da psicologia. Este é um estudo bibliográfico, descritivo e exploratório. A partir de buscas nas bases de dados BDTD, BVS, BVS-Psi, Google Acadêmico, PePSIC e SciELO, foram selecionadas 147 pesquisas sendo todas enquadradas na modalidade de campo, nacionais e publicadas na última década, portanto, entre 2010 à 2019. Descobriu-se que as configurações estudadas foram as heterossexuais, homossexuais e monoparentais. Onze foram as subáreas pesquisadoras do tema. Várias e significativas são as contribuições da psicologia. Considera-se por fim que as pesquisas se caracterizam ricas em determinados assuntos e pobres em tantos outros.
Utilização de azul de metileno para investigar a capacidade adsortiva de biomassas
Authors: Castro Matheus Campos , Alves Eloize Silva , Saqueti Bruno Henrique Figueiredo , Montanher Silvana Fernandes
Published: November 2021

O presente trabalho tem como objetivo avaliar a capacidade de adsorção de biomassas, bagaço de laranja (Citrus Sinensis), serragens de Pinus elliotti e Mezilaurus itaúba e cascas de ovos frente ao corante azul de metileno, além de avaliar a montagem do empacotamento da coluna, e após isso verificar se o processo de dessorção foi possível de ser realizado. Para isso os estudos de adsorção foram realizados em coluna de leito fixo utilizando como adsorvente, bagaço de laranja, serragem pinus elliotti, serragem mezilaurus itaúba e cascas de ovos, o processo de adsorção foi realizado como solução extratora ácido clorídrico 1,0 mol L-1. Foi possível observar que utilizando como adsorvente as cascas de ovos, a adsorção era lenta (0,02 mL min-1), e o processo de adsorção não ocorria, já as demais biomassas o processo de adsorção aconteceu, sendo que a biomassa que apresentou melhor valor foi o bagaço de laranja, apresentando capacidade máxima de adsorção de 63 mg g-1, sendo que a serragem pinus elliotti e itaúba apresentaram 29,0 e 15,6 mg g-1 respectivamente. O processo de dessorção foi viável quando utilizando-se como adsorvente ambas as serragens, porém utilizando-se o bagaço de laranja o mesmo não foi observado, pois o processo de dessorção se tornou extremamente lento, cerca de 5 mL h-1, impossibilitando o estudo desse parâmetro. Com isso foi possível concluir que a melhor biomassa testada, foi o bagaço de laranja, ou seja, a qual apresenta a maior capacidade adsortiva para o corante azul de metileno.
Violência obstétrica institucional: uma questão sobre os direitos da mulher
Authors: Moura Amanda Faber Pedro , Tomasoni Yasmin Ferrari , Guimarães Bianca Macêdo , Camargo Marília Ferreira , Borges Mariana do Prado , Markus Jandrei Rogério
Published: November 2021

Objetivo: Esta revisão integrativa tem como objetivo compreender através da literatura como se estabeleceu o        processo institucional da violência obstétrica na mulher levando em conta que este fenômeno é reconhecido através de diferentes tipos de agressões que podem ocorrer no contexto da gestação, parto, puerpério, como também em situações de aborto, pós-aborto e ciclo reprodutivo. Metodologia: Trata-se de uma revisão integrativa de literatura onde foram selecionados artigos utilizando as plataformas do SciELO, PUBMED e MEDLINE e foram escolhidos para o espaço amostral da pesquisa apenas artigos publicados em português, inglês ou espanhol e uma cartilha, que retrataram a temática referente à ocorrência da violência obstétrica e artigos publicados e indexados nos referidos bancos de dados dos últimos 21 anos. Nesta revisão integrativa, realizamos atividades de busca de informações, compilação e registro dos artigos selecionados. Resultados e discussão: A violência obstétrica ainda é uma realidade, ocorrendo principalmente com mulheres de baixa renda e escolaridade, expressando-se através de abusos verbais, procedimentos desnecessários, entre outras formas. Isso se dá pela falta de preparo da equipe de saúde, leis e a não conscientização da mulher. Conclusão: A Violência obstétrica caracteriza-se por práticas inadequadas contra a mulher no período gestacional. É notório o prejuízo psicológico a esta parturiente. Para diminuir essa realidade são necessários projetos de leis que amparam as mulheres, a conscientização das mesmas durante o pré-natal, e uma formação mais humanizada dos futuros profissionais da saúde.
M7 to M2 Pre-congestion Speed Management
Authors: Clark Timothy , Gray Sam
Published: November 2021

This paper explores the development and implementation of the M7 to M2 pre-congestion speed limit management trial conducted on workdays between 26th June 2018 and 31st December 2018. This trial was the first of its kind in NSW and was implemented using a live loop reporting system utilising key trigger values (specific loop metrics) to identify the opportune time to reduce speed limits prior to flow breakdown. Through measuring the rate at which speeds dropped during flow breakdown, the heatmap footprint of congestion, and the instance of congestion related crashes it was established the trial was able to have a calming effect on traffic flow and reduce the overall footprint of congestion.
The AAA Approach to Crash Investigation Reform – The Perspective from Road Policing Practitioners
Authors: Shuey Ray , Myers Des
Published: November 2021

Professional road crash investigation, complemented by intelligent analysis and dynamic actions provide the foundation for road safety reform. However, to date, the real potential resulting from police investigative findings have not been fully realised due to the lack of streamlined connectivity from the crash scene to the reform process. Such deficiencies include inadequate investigations, inadequate data management, convoluted processes, system delays, inadequate analysis and limited immediate and mid-term actions which should be generated following thorough and efficient investigations. A review of processes across high, medium and low-income countries has identified a more effective approach to achieving results in road safety reform across all road safety disciplines. The simple AAA framework to ‘Acquire, Analyse and Action’ is presented as a contemporary model to ensure an evidence-based foundation drives road safety reform to identify root cause analysis locally, nationally and globally. This provides structure, discipline and purpose as well as technical skill and competence to achieve practical recommendations as preventative measures for crash reduction. A multi-disciplined expert review team to validate/assess/modify these recommendations in serious crashes ensures constructive countermeasures are prioritised and actioned. This facilitates a paradigm shift in thinking and analysis to achieve a continuous improvement process designed to reduce road trauma and save lives.
Investigation of Contributing Factors to Traffic Crash Severity in Southeast Texas Using Multiple Correspondence Analysis
Authors: Li Guanlong , Li Yueqing , Li Yalong , Craig Brian , Wu Xing
Published: November 2021

Driving is the essential means of travel in Southeast Texas, a highly urbanized and populous area that serves as an economic powerhouse of the whole state. However, driving in Southeast Texas is subject to many risks as this region features a typical humid subtropical climate with long hot summers and short mild winters. Local drivers would encounter intense precipitation, heavy fog, strong sunlight, standing water, slick road surface, and even frequent extreme weather such as tropical storms, hurricanes and flood during their year-around travels. Meanwhile, research has revealed that the fatality rate per 100 million vehicle miles driven in urban Texas became considerably higher than national average since 2010, and no conclusive study has elucidated the association between Southeast Texas crash severity and potential contributing factors. This study used multiple correspondence analysis (MCA) to examine a group of contributing factors on how their combinatorial influences determine crash severity by creating combination clouds on a factor map. Results revealed numerous significant combinatorial effects. For example, driving in rain and extreme weather on a wet road surface has a higher chance in causing crashes that incur severe or deadly injuries. Besides, other contributing factors involving risky behavioral factors, road designs, and vehicle factors were well discussed. The research outcomes could inspire local traffic administration to take more effective countermeasures to systematically mitigate road crash severity.
Decomposition of Kemp’s ridley (Lepidochelys kempii) and green (Chelonia mydas) sea turtle carcasses and its application to backtrack modeling of beach strandings
Authors: Nero RW , Cook M , Reneker JL , Wang Z , Schultz EA , Stacy BA
Published: November 2021

When a sea turtle dies, it typically sinks to the bottom, begins decomposing, and floats to the surface once sufficient internal gases have accumulated to produce positive buoyancy. This process is poorly characterized and is essential to understanding where and when sea turtles found on shore may have died. We conducted decomposition studies with detailed time-temperature histories using carcasses of cold-stunned sea turtles (22 Kemp’s ridleys Lepidochelys kempii and 15 green sea turtles Chelonia mydas) at temperatures of 14-32°C and depths of 2.2-9.5 m. We found strong depth/pressure-related effects; carcasses took longer to float when incubated at greater depths than shallower depths at similar temperatures. Furthermore, carcasses incubated at colder temperatures (~15°C) took 8 times longer to float than those at 32°C at the same depth. We applied accumulated degree hours (ADH; hourly sum of ambient temperatures a carcass experienced) to characterize environmental conditions associated with different stages of decomposition and key events, including buoyancy and sinking. A formula for temperature-correction of ADH was calculated to fit a non-linear increase in decomposition at higher temperatures. These data were then used to improve an existing backtracking model by incorporating water temperature, depth (pressure), bathymetry, and postmortem condition. Heat maps of the probable mortality locations from the model agreed well with carcass and effigy drift experiments, demonstrating the overall reliability of the enhanced model. Our method can be used to estimate at-sea locations where sea turtles found washed ashore in the northern Gulf of Mexico likely died and may help inform similar efforts in other regions.
DESAIN PROGRAM PENDIDIKAN AGAMA KRISTEN BAGI PEMUDA DI MASA PANDEMI DAN PASCA PANDEMI COVID-19
Authors: Telaumbanua Sozawato
Published: November 2021

Pemuda merupakan generasi penerus bangsa maupun gereja. Namun di tengah pandemi Covid-19, para pemuda tidak luput mengalami dampak yang diakibatkan oleh Covid-19 ini. Sebagian pemuda mengalami stres dalam mengikuti sekolah/perkuliahan online, stres karena kehilangan pekerjaan akibat pemutusan hubungan kerja (PHK) oleh perusahaan di mana mereka bekerja, bosan karena lebih banyak waktu di rumah dan jarang ketemu dengan teman-teman sebaya, jarang ketemu dengan anggota komunitas gereja, bahkan mereka terpaksa hanya bisa beribadah dari rumah. Tidak sedikit pemuda mengalami penurunan dalam hal kerohanian selama masa pandemi ini. Gereja sebagai sebuah komunitas orang percaya harus hadir serta menjawab kebutuhan para pemuda yang sedang mengalami dampak pandemi Covid-19 ini. Di tengah keterbatasan di masa pandemi ini, gereja bisa hadir serta memaksimalkan pelayanan kepada pemuda melalui desain program yang bisa menjawab kebutuhan mereka. Tentunya gereja bisa memanfaatkan teknologi yang berkembang saat ini sehingga pelayanan kepada pemuda, baik di saat pandemi maupun pasca pandemi, tetap berjalan. Oleh karenanya, melalui artikel ini penulis menawarkan sebuah desain program pendidikan agama Kristen bagi pemuda, di mana dalamnya para pemuda bisa memuji Tuhan bersama (praise), berbagi kesaksian (sharing) serta berdoa (pray) bersama. Untuk menjawab permasalahan pemuda tersebut di atas, maka dalam penulisan artikel ini penulis menggunakan metode penelitian kualitatif, yakni membandingkan berbagai literatur, baik itu buku-buku, artikel, maupun jurnal yang berkaitan dengan pembahasan di atas. Tujuan dari tulisan ini adalah menawarkan desain program pendidikan agama Kristen bagi pemuda di masa Pandemi dan Pasca Pandemi. Program ini diharapkan menjawab kebutuhan para pemuda sekaligus membekali mereka melalui terang firman Tuhan agar para pemuda ini tetap berakar, bertumbuh dan berbuah di dalam Kristus dalam segala keadaaan.
Випадок прогресивної деменції на тлі пізнього нейросифілісу
Authors:   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Bondarenko G. M. , Nikitenko I. N. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Bezruchenko A. A. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Kutova V. V. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Gubenko T. V. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine»
Published: November 2021

The objective. Prevention of diagnostic errors associated with the rare detection of syphilis in patients in neurological hospitals. Results. A clinical case from the practice of dermatovenereologists is given. Conclusions. For timely detection of neurosyphilis it is necessary to conduct a cerebrospinal fluid examination of all patients in the neurological hospital who have a positive result of non-treponemal and treponemal tests in the serum.
Developing Empathy with STEAM Learning in Grade VIII SMP Lazuardi Al-Falah Depok
Authors: Kumala Febriandrini
Published: November 2021

Empathy (Burns and Lesseig, 2017) is a skill that is rarely discussed in planning mathematics lessons. The objective of this research is to initiate and explore how mathematics learning can develop empathy skills to students using STEAM based project. This research use qualitative method, in which the observation was executed when students were developing until launching the application prototype to a limited audience. The application created with Google Sheets was called Your Energy Counter, intended to count the energy gathered from the food consumed by the user. This research revealed how empathy was formed during the project execution and how students are able to reflect on themselves being empathetic to others during mathematics lessons.
The Effect of Student Resilience and Self-Regulated Learning On Academic Achievement
Authors: Galizty Risa Cahya Maulani Falencya , Sutarni Nani
Published: November 2021

This study aims to determine the effect of student resilience and self-regulated learning on student academic achievement in economics subjects. The research method used is an explanatory survey using a questionnaire as a data collection. The population in this study were students of class XI and XII of Social Science senior high school in Cianjur regency for the academic year 2021/2022 and a sample of 237 students was taken using simple random sampling technique. The data analysis technique used is multiple linear regression analysis. The results showed that resilience and self-regulated learning had an effect on students' academic achievement in economics subjects
Зонирование территории МО г. Тулы по карстопроявлению
Authors: Басова Ирина Анатольевна , Чекулаев Виктор Владимирович
Published: November 2021

В результате анализа выявлена степень пораженности территории г. Тула карстовыми процессами; на основе изучения литологического состава массива горных пород, тектонической нарушенности и интенисвности проявления на поверхностии предложена карта-схема зонирования территории МО г. Тула по фактору карстообразования.
Геоинформационный анализ расположения зон вероятного возникновения чрезвычайных ситуаций на территории города Иркутска
Authors: Бельц Мария Николаевна , Дубровский Алексей Викторович
Published: November 2021

В статье рассмотрены чрезвычайнее ситуации, которые могут оказать влияние на стоимость объектов недвижимости, выполнен геоинформационный анализ расположения зон вероятного возникновения чрезвычайных ситуаций на территории города Иркутск, на основе анализа сформирована общая схема потенциально опасных территорий города. При выполнении работ используется геоинформационная система с картой-схемой территории города Иркутск, а также План гражданской обороны чрезвычайных ситуаций города Иркутск, который опирается на требования СНиП 2.01.51-90 «Инженерно-технические мероприятия гражданской обороны».
Перспективные методы мониторинга последствий разливов нефтепродуктов по данным дистанционного зондирования Земли
Authors: Гордиенко Антонина Сергеевна
Published: November 2021

В статье обоснована актуальность исследования и разработки методов применения данных дистанционного зондирования Земли при мониторинге последствий разливов нефтепродуктов. Описываются основные методы распознавания загрязнений нефтью водной поверхности и суши. Приводятся их достоинства и недостатки. Обсуждаются результаты выполненного обзора. Сделан вывод о необходимости определить оптимальное соотношение пространственного и спектрального разрешения снимков для установления связи между загрязнением нефтью и угнетением растительности. Предложены направления дальнейших исследований по разработке методов мониторинга последствий разливов нефти по данным дистанционного зондирования Земли с целью повышения их достоверности за счет комплексного подхода и адаптации к различным природно-территориальным комплексам.
Pembatasan Penggantian Pejabat Defenitif Dalam Jangka Waktu 6 (enam) Bulan Setelah Pelantikan Kepala Daerah Dalam Penyelenggaraan Pemerintahan Daerah
Authors: Hidayat Rahmad , Sensu La , Jafar Kamaruddin
Published: November 2021

Penelitian ini dilakukan untuk mengetahui apakah pembatasan penggantian pejabat definitif sebelum enam bulan setelah pelantikan tidak bertentangan dengan tanggung jawab jabatan Kepala Daerah, dan mengetahui peluang digunakannya diskresi oleh Kepala Daerah jika terdapat kondisi-kondisi yang memungkinkan untuk diterbitkannya diskresi tersebut. Jenis penelitian ini adalah penelitian hukum normatif yang menggunakan pendekatan perundang-undangan dan pendekatan konseptual sehingga dalam proses penelitian dilakukan dengan menelaah peraturan perundang-undangan yang terkait dan konseptual yang berhubungan dengan permasalahan hukum yang terjadi serta teori-teori hukum yang relevan. Berdasarkan hasil penelitian menunjukkan bahwa: Pertama, Pembatasan penggantian pejabat definitif yang diatur dalam UU Pilkada telah menghambat kepala daerah dalam menjalankan tugasnya menciptakan pelayanan publik didaerah sehingga aturan ini telah bertentangan dengan tanggung jawab jabatan Kepala Daerah dimana senantiasa dituntut dan bertanggung jawab untuk menjawab ekspektasi masyarakat dalam menciptakan pelayanan publik yang efektif di daerah. Kedua, tindakan diskresi dapat digunakan untuk melakukan penggantian pejabat definitif di daerah sebelum mencapai jangka waktu enam bulan setelah pelantikan selama terdapat kondisi-kondisi mendesak dan persoalan yang mengakibatkan terjadinya stagnasi pemerintahan yang timbul secara tiba-tiba dan tindakan tersebut dilakukan semata-mata untuk tugas-tugas pelayanan publik dan tindakan tersebut dapat dipertanggungjawabkan secara moral dan secara hukum.
Prognostic Value of a Ferroptosis-Related Gene Signature in Patients With Head and Neck Squamous Cell Carcinoma
Authors: He Dongsheng , Liao Shengyin , Xiao Linlin , Cai Lifang , You Mengxing , He Limei , Huang Weiming
Published: November 2021

Background: Ferroptosis is an iron-dependent programmed cell death (PCD) form that plays a crucial role in tumorigenesis and might affect the antitumor effect of radiotherapy and immunotherapy. This study aimed to investigate distinct ferroptosis-related genes, their prognostic value and their relationship with immunotherapy in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: The differentially expressed ferroptosis-related genes in HNSCC were filtered based on multiple public databases. To avoid overfitting and improve clinical practicability, univariable, least absolute shrinkage and selection operator (LASSO) and multivariable Cox algorithms were performed to construct a prognostic risk model. Moreover, a nomogram was constructed to forecast individual prognosis. The differences in tumor mutational burden (TMB), immune infiltration and immune checkpoint genes in HNSCC patients with different prognoses were investigated. The correlation between drug sensitivity and the model was firstly analyzed by the Pearson method.

Results: Ten genes related to ferroptosis were screened to construct the prognostic risk model. Kaplan-Meier (K-M) analysis showed that the prognosis of HNSCC patients in the high-risk group was significantly lower than that in the low-risk group (P < 0.001), and the area under the curve (AUC) of the 1-, 3- and 5-year receiver operating characteristic (ROC) curve increased year by year (0.665, 0.743, and 0.755). The internal and external validation further verified the accuracy of the model. Then, a nomogram was build based on the reliable model. The C-index of the nomogram was superior to a previous study (0.752 vs. 0.640), and the AUC (0.729 vs. 0.597 at 1 year, 0.828 vs. 0.706 at 3 years and 0.853 vs. 0.645 at 5 years), calibration plot and decision curve analysis (DCA) also shown the satisfactory predictive capacity. Furthermore, the TMB was revealed to be positively correlated with the risk score in HNSCC patients (R = 0.14; P < 0.01). The differences in immune infiltration and immune checkpoint genes were significant (P < 0.05). Pearson analysis showed that the relationship between the model and the sensitivity to antitumor drugs was significant (P < 0.05).

Conclusion: Our findings identified potential novel therapeutic targets, providing further potential improvement in the individualized treatment of patients with HNSCC.
LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5
Authors: Gui Zhifu , Zhao Zhenguo , Sun Qi , Shao Guoyi , Huang Jianming , Zhao Wei , Kuang Yuting
Published: November 2021

Long non-coding RNAs (lncRNAs) play important roles in human cancers including gastric cancer (GC). Dysregulation of lncRNAs is involved in a variety of pathological activities associated with gastric cancer progression and chemo-resistance. However, the role and molecular mechanisms of FEZF1-AS1 in chemoresistance of GC remain unknown. In this study, we aimed to determine the role of FEZF1-AS1 in chemoresistance of GC. The level of FEZF1-AS1 in GC tissues and GC cell lines was assessed by qRT-PCR. Our results showed that the expression of FEZF1-AS1 was higher in gastric cancer tissues than in adjacent normal tissues. Multivariate analysis identified that high level of FEZF1-AS1 is an independent predictor for poor overall survival. Increased FEZF1-AS1 expression promoted gastric cancer cell proliferation in vitro. Additionally, FEZF1-AS1 was upregulated in chemo-resistant GC tissues. The regulatory effect of FEZF1-AS1 on multi-drug resistance (MDR) in GC cells and the underlying mechanism was investigated. It was found that increased FEZF1-AS1 expression promoted chemo-resistance of GC cells. Molecular interactions were determined by RNA immunoprecipitation (RIP) and the results showed that FEZF1-AS1 regulated chemo-resistance of GC cells through modulating autophagy by directly targeting ATG5. The proliferation and autophagy of GC cells promoted by overexpression of LncFEZF1-AS1 was suppressed when ATG5 was knocked down. Moreover, knockdown of FEZF1-AS1 inhibited tumor growth and increased 5-FU sensitivity in GC cells in vivo. Taken together, this study revealed that the FEZF1-AS1/ATG5 axis regulates MDR of GC cells via modulating autophagy.
Molecular Surveillance and Ex Vivo Drug Susceptibilities of Plasmodium vivax Isolates From the China–Myanmar Border
Authors: Zeng Weilin , Zhao Hui , Zhao Wei , Yang Qi , Li Xinxin , Li Xiaosong , Duan Mengxi , Wang Xun , Li Cuiying , Xiang Zheng , Chen Xi , Cui Liwang , Yang Zhaoqing
Published: November 2021

Drug resistance in Plasmodium vivax may pose a challenge to malaria elimination. Previous studies have found that P. vivax has a decreased sensitivity to antimalarial drugs in some areas of the Greater Mekong Sub-region. This study aims to investigate the ex vivo drug susceptibilities of P. vivax isolates from the China–Myanmar border and genetic variations of resistance-related genes. A total of 46 P. vivax clinical isolates were assessed for ex vivo susceptibility to seven antimalarial drugs using the schizont maturation assay. The medians of IC50 (half-maximum inhibitory concentrations) for chloroquine, artesunate, and dihydroartemisinin from 46 parasite isolates were 96.48, 1.95, and 1.63 nM, respectively, while the medians of IC50 values for piperaquine, pyronaridine, mefloquine, and quinine from 39 parasite isolates were 19.60, 15.53, 16.38, and 26.04 nM, respectively. Sequence polymorphisms in pvmdr1 (P. vivax multidrug resistance-1), pvmrp1 (P. vivax multidrug resistance protein 1), pvdhfr (P. vivax dihydrofolate reductase), and pvdhps (P. vivax dihydropteroate synthase) were determined by PCR and sequencing. Pvmdr1 had 13 non-synonymous substitutions, of which, T908S and T958M were fixed, G698S (97.8%) and F1076L (93.5%) were highly prevalent, and other substitutions had relatively low prevalences. Pvmrp1 had three non-synonymous substitutions, with Y1393D being fixed, G1419A approaching fixation (97.8%), and V1478I being rare (2.2%). Several pvdhfr and pvdhps mutations were relatively frequent in the studied parasite population. The pvmdr1 G698S substitution was associated with a reduced sensitivity to chloroquine, artesunate, and dihydroartemisinin. This study suggests the possible emergence of P. vivax isolates resistant to certain antimalarial drugs at the China–Myanmar border, which demands continuous surveillance for drug resistance.
IDH1 R132C and ERC2 L309I Mutations Contribute to the Development of Maffucci’s Syndrome
Authors: Cheng Peng , Chen Kun , Zhang Shu , Mu Ke-tao , Liang Shuang , Zhang Ying
Published: November 2021

Background

Maffucci’s syndrome is characterized by the coexistence of multiple enchondromas and soft-tissue hemangiomas. It has been clear that somatic mosaic isocitrate dehydrogenase type 1 (IDH1) or isocitrate dehydrogenase type 2 (IDH2) mutations are associated with Maffucci’s syndrome and Ollier disease, but the mechanisms underlying hemangiomas of the Maffucci’s syndrome is still obscure. This study aimed to determine the mechanism of hemangiomas in Maffucci’s syndrome.

Methods

We received a 26-year-old female patient with typical Maffucci’s syndrome, and exome sequencing was conducted using DNA from her peripheral blood and enchondroma tissues. Somatic mutations were characterized by a comparative analysis of exome sequences and further confirmed by the sequencing of PCR products derived from original blood and tissue samples. The mutations of an additional 69 patients with Ollier disease were further tested. The functional impacts of these somatic mutations on Maffucci’s syndrome, especially the development of hemangiomas, were evaluated.

Results

We reported a typical case of Maffucci’s syndrome, which was confirmed by both imaging findings and pathology. Through exome sequencing of this patient’s DNA samples, we identified an R132C mutation in the isocitrate dehydrogenase type 1 (IDH1) gene and an L309I mutation in the ELKS/RAB6-interacting/CAST family member 2 (ERC2) gene in this patient. Approximately 33.3% of the clones were positive for the IDH1 R132C mutation, and 19.0% of the clones were positive for the ECR2 L309I mutation. The IDH1 R132C mutation was detected in most of the patients with Ollier disease (51/69 patients), and the mean frequency of this mutation was 63.3% in total sequence readouts, but the ECR2 L309I mutation was absent in all of the patients with Ollier disease. In vitro experiments confirmed that the IDH1 R132C mutation promotes chondrocyte proliferation, and the ERC2 L309I mutation enhances angiogenesis.

Conclusions

Our results suggest that while IDH1 is a known pathogenic gene in enchondromatosis, ERC2 is a novel gene identified in Maffucci’s syndrome. The somatic L309I mutation of ERC2 contributes to the pathogenesis of hypervascularization to facilitate the development of hemangiomas in Maffucci’s syndrome. The combination of the IDH1 R132C and ERC2 L309I mutations contributes to the development of Maffucci’s syndrome, and these results may enable further research on the pathogenesis of Maffucci’s syndrome.
Identification and Analysis of Small Interfering RNAs Associated With Heat Stress in Flowering Chinese Cabbage Using High-Throughput Sequencing
Authors: Ahmed Waqas , Xia Yanshi , Li Ronghua , Zhang Hua , Siddique Kadambot H.M , Guo Peiguo
Published: November 2021

Endogenous small interfering RNAs (siRNAs) are substantial gene regulators in eukaryotes and play key functions in plant development and stress tolerance. Among environmental factors, heat is serious abiotic stress that severely influences the productivity and quality of flowering Chinese cabbage (Brassica campestris L. ssp. chinensis var. utilis Tsen et Lee). However, how siRNAs are involved in regulating gene expression during heat stress is not fully understood in flowering Chinese cabbage. Combining bioinformatical and next-generation sequencing approaches, we identified heat-responsive siRNAs in four small RNA libraries of flowering Chinese cabbage using leaves collected at 0, 1, 6, and 12 h after a 38°C heat-stress treatment; 536, 816, and 829 siRNAs exhibited substantial differential expression at 1, 6, and 12 h, respectively. Seventy-five upregulated and 69 downregulated differentially expressed siRNAs (DE-siRNAs) were common for the three time points of heat stress. We identified 795 target genes of DE-siRNAs, including serine/threonine-protein kinase SRK2I, CTR1-like, disease resistance protein RML1A-like, and RPP1, which may play a role in regulating heat tolerance. Gene ontology showed that predictive targets of DE-siRNAs may have key roles in the positive regulation of biological processes, organismal processes, responses to temperature stimulus, signaling, and growth and development. These novel results contribute to further understanding how siRNAs modulate the expression of their target genes to control heat tolerance in flowering Chinese cabbage.