bluuebunny/crossref_metadata_2025 huggingface dataset:
Running with whole-body electromyostimulation improves physiological determinants of endurance performance – a randomized control trial
Authors: Krause Anne , Walser Nicolas , Centner Christoph , Memmert Daniel , da Mota de Moreia Ivo , Ritzmann Ramona
Published: October 2023

Background

This study aimed to evaluate the physiological and metabolic adaptations to an eight-week running intervention with whole-body electromyostimulation (wbEMS) compared to running without wbEMS.

Methods

In a randomized controlled trial (RCT), 59 healthy participants (32 female/ 27 male, 41 ± 7 years, rel.V̇O2max 40.2 ± 7.4 ml/min/kg) ran twice weekly à 20 min for eight weeks either with a wbEMS suit (EG) or without wbEMS (control group, CG). Before and after the intervention, (i) rel.V̇O2max, heart rate and time to exhaustion were recorded with an incremental step test with an incremental rate of 1.20 km/h every 3 min. They were interpreted at aerobic and (indirect) anaerobic lactate thresholds as well as at maximum performance. (ii) Resting metabolic rate (RQ) as well as (iii) body composition (%fat) were assessed.

Results

Following the intervention, V̇O2max was significantly enhanced for both groups (EG ∆13 ± 3%, CG ∆9 ± 3%). Velocity was elevated at lactate thresholds and maximum running speed (EG ∆3 ± 1%, CG ∆2 ± 1%); HRmax was slightly reduced by -1 beat/min. No significant changes were observed for time until exhaustion and lactate. RQ was significantly enhanced following both trainings by + 7%. %fat was reduced for both groups (EG ∆-11 ± 3%, CG ∆-16 ± 5%), without any changes in body mass. Results did not differ significantly between groups.

Conclusions

Both interventions had a positive impact on aerobic power. The rightward shift of the time-velocity graph points towards improved endurance performance. The effects of wbEMS are comparable to those after high-intensity training and might offer a time-efficient alternative to affect physiological and metabolic effects.

Trial registration

German Clinical Trials Register, ID DRKS00026827, date 10/26/21.
Evaluation of the health-related quality of life and associated factors in Zimbabwean adults living with HIV: a cross-sectional study
Authors: Tigirigi Tendai Orial , Sithole Grace Yolanda , Chakara Princess , Chirombo Gracious Z. , Chiweza Annamore Rutendo , Mubayiwa Trish R. , Muchemwa Sidney , Chibanda Dixon , Dambi Jermaine M.
Published: October 2023

Objective

HIV remains a global burden, with the Sub-Saharan Africa (SSA) region reporting the largest number of people living with HIV/AIDS (PLHIV). An exponential improvement in the accessibility and uptake of antiretroviral treatment across SSA has significantly improved outcomes for PLHIV. Hence, HIV care goals have shifted from reducing mortality and morbidity to improving health-related quality of life (HRQoL). This study uses generic and condition-specific HRQoL outcomes to holistically determine the HRQoL of Zimbabwean adult PLHIV and associated factors. HRQoL is a dynamic subject construct that warrants continuous evaluation to provide meaningful feedback to various stakeholders. We enrolled 536 adult PLHIV in Zimbabwe. Collected data were analyzed through descriptive statistics and multivariate binary logistic regression.

Results

Our study shows a high HRQoL perception by Zimbabwean PLHIV. Anxiety, depression, and poor environmental health were widely reported domains influencing HRQoL. Also, being aware of HIV status for over a year, not experiencing an adverse event, being married, having adequate finances and food security and having higher educational status were associated with higher HRQoL. It is essential to integrate mental health care into routine HIV care to improve treatment outcomes and HRQoL. Last, implementing bespoke multisectoral HRQoL-enhancement interventions is paramount.
Coronary slow flow research: a bibliometric analysis
Authors: Tong Jing , Bei Gui-Guang , Zhang Li-Bo , Yang Ben-Qiang
Published: October 2023

Background

Studies on coronary slow flow are receiving increasing attention, but objective evaluations are still lacking. The purpose of this study was to visualize the current status and research hotspots of coronary slow flow through bibliometric analysis.

Methods

All relevant publications on coronary slow flow from 2003 to 2022 were extracted from the Web of Science Core Collection database and analyzed by VOSviewer and CiteSpace visualization software. Year of publication, journal, country/region, institution, and first author of each paper, as well as research hotspots were identified.

Results

A total of 913 publications were retrieved. The journal with the most publications was Coronary Artery Disease. The country/region with the most publications was Turkey, followed by China and the United States. The institution with the largest publication volume was Turkey Specialized Higher Education Research Hospital. The author with the largest publication volume was Chun-Yan Ma from China. Keyword analysis indicated that “treatment and prognosis”, “pathogenesis and risk factors” and “diagnosis” were the clustering centers of coronary slow flow, and the research hotspots gradually changed with time, from pathogenesis to treatment and prognosis.

Conclusion

Future research will focus on the search for effective and non-invasive detection indicators and treatments of coronary slow flow. Collaboration needs to be enhanced between different institutions or countries/regions, which would improve clinical outcomes for patients with coronary slow flow.
Identification of a novel NPM1 mutation in acute myeloid leukemia
Authors: Yao Yiyi , Lin Xiangjie , Wang Chen , Gu Ying , Jin Jie , Zhu Yinghui , Wang Huafeng
Published: October 2023

Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It is estimated that 25–35% of adult patients with acute myeloid leukemia (AML) carryNPM1mutations. The classicNPM1type A mutation occurs in exon 12, which accounts for 75–80% of adult patients withNPM1-mutated AML. It produces an additional leucine and valine-rich nuclear export signal (NES) at the C-terminus, and causes aberrant cytoplasmic dislocation of NPM1 protein. Notably, emerging evidence indicates that besides the classic type A mutation, rare mutants occurring in other exons may also lead to the imbalance of the nucleocytoplasmic shuttle of NPM1. Identification of novel non-type A mutants is crucial for the diagnosis, prognosis, risk stratification and disease monitoring of potential target populations. Here we reported a novelNPM1mutation in exon 5 identified from a de novo AML patient. Similar to the classic type A mutation, the exon 5 mutation had the NPM1 mutant bound to exportin-1 and directed the mutant into the cytoplasm by generating an additional NES sequence, resulting in aberrant cytoplasmic dislocation of NPM1 protein, which could be reversed by exportin-1 inhibitor leptomycin B. Our findings strongly support that besides the exon 12 mutation, the exon 5 mutant is anotherNPM1“born to be exported” mutant critical for leukemogenesis. Therefore, similar to the classic type A mutation, the identification of our novelNPM1mutation is beneficial for clinical laboratory diagnosis, genetic risk assessment and MRD monitoring.
Definitions, End Points, and Clinical Trial Designs for Bladder Cancer: Recommendations From the Society for Immunotherapy of Cancer and the International Bladder Cancer Group
Authors: Kamat Ashish M. , Apolo Andrea B. , Babjuk Marek , Bivalacqua Trinity J. , Black Peter C. , Buckley Roger , Campbell Matthew T. , Compérat Eva , Efstathiou Jason A. , Grivas Petros , Gupta Shilpa , Kurtz Neil J. , Lamm Donald , Lerner Seth P. , Li Roger , McConkey David J. , Palou Redorta Joan , Powles Thomas , Psutka Sarah P. , Shore Neal , Steinberg Gary D. , Sylvester Richard , Witjes J. Alfred , Galsky Matthew D.
Published: October 2023

PURPOSE

There is a significant unmet need for new and efficacious therapies in urothelial cancer (UC). To provide recommendations on appropriate clinical trial designs across disease settings in UC, the Society for Immunotherapy of Cancer (SITC) and the International Bladder Cancer Group (IBCG) convened a multidisciplinary, international consensus panel.

METHODS

Through open communication and scientific debate in small- and whole-group settings, surveying, and responses to clinical questionnaires, the consensus panel developed recommendations on optimal definitions of the disease state, end points, trial design, evaluations, sample size calculations, and pathology considerations for definitive studies in low- and intermediate-risk nonmuscle-invasive bladder cancer (NMIBC), high-risk NMIBC, muscle-invasive bladder cancer in the neoadjuvant and adjuvant settings, and metastatic UC. The expert panel also solicited input on the recommendations through presentations and public discussion during an open session at the 2021 Bladder Cancer Advocacy Network (BCAN) Think Tank (held virtually).

RESULTS

The consensus panel developed a set of stage-specific bladder cancer clinical trial design recommendations, which are summarized in the table that accompanies this text.

CONCLUSION

These recommendations developed by the SITC-IBCG Bladder Cancer Clinical Trial Design consensus panel will encourage uniformity among studies and facilitate drug development in this disease.
Τα άνθη στην αιγαιακή εικονογραφία της εποχής του χαλκού
Authors: Παπαγεωργίου Αθανάσιος
Published: October 2023

Αναμφίβολα τα άνθη ως συστατικό στοιχείο της φύσης δεν είναι τυχαίο που αποτελούν αναπόσπαστο κομμάτι της εικονιστικής τέχνης της Αιγαιακής Χαλκοκρατίας. Από την τοιχογραφία, την κεραμεική έως την μικρογλυπτική, την ειδωλοπλαστική και την κοσμηματοτεχνία διάφορα μοτίβα ανθέων «διανθίζουν» τον υλικό πολιτισμό των προϊστορικών κατοίκων του Αιγαίου. Ωστόσο, στόχος της διατριβής υπό τον τίτλο «Τα Άνθη στην Αιγαιακή Εικονογραφία της Εποχής του Χαλκού» δεν είναι μόνο η δημιουργία μίας ολοκληρωμένης εικόνας για την τυπολογία, ερμηνεία και σημασία των ανθέων στις παραστατικές τέχνες, αλλά και η βαθύτερη κατανόηση του ρόλου και της συνεισφοράς τους στην Αιγαιακή κοινωνία της Εποχής του Χαλκού. Συνολικά, η παρούσα διατριβή διαρθρώνεται σε 8 επιμέρους κεφάλαια εξαιρουμένων της εισαγωγής και των συμπερασμάτων. Στην εισαγωγή ορίζονται επιγραμματικά και συνοπτικά οι ερευνητικές γραμμές, το πλαίσιο και η δομή της μελέτης. Ακολούθως, το 1ο Κεφάλαιο αναφέρεται στην ιστορία της έρευνας πάνω στην συγκεκριμένη θεματική. Γίνεται σύντομη αναφορά πάνω στις σημαντικότερες μελέτες από τις απαρχές της εκδήλωσης ενδιαφέροντος των ερευνητών για την παρουσία των ανθέων στο αρχαιολογικό υλικό έως και σήμερα. Στο 2ο Κεφάλαιο συζητείται η μεθοδολογία αναφορικά με την προσέγγιση του υλικού. Στο 3ο Κεφάλαιο παρουσιάζονται όλα τα δημοσιευμένα εικονογραφικά παραδείγματα στα οποία απαντούν μοτίβα ανθέων. Δίνεται μεγαλύτερη έμφαση στην τοιχογραφία καθώς είναι το εικονογραφικό μέσο από το οποίο αντλούνται οι περισσότερες πληροφορίες σχετικά με τον χαρακτήρα και την συμβολική διάσταση των ανθέων. Στο 4ο Κεφάλαιο γίνεται παράθεση των δεδομένων που αφορούν στην παρουσία των ανθέων στα γραπτά κείμενα της Αιγαιακής Χαλκοκρατίας, δηλαδή τις Γραμμικές γραφές (Ιερογλυφική, Γραμμική Α και Β γραφή). Στο 5ο Κεφάλαιο αναφέρονται τα όποια δεδομένα διαθέτουμε για κάθε άνθος μέσα από τις αναλύσεις του αρχαιοβοτανικού υλικού. Το 6ο Κεφάλαιο εξετάζει το ακανθώδες ζήτημα του συμβολισμού και χωρίζεται σε δύο υποκεφάλαια. Το α΄ υποκεφάλαιο πραγματεύεται το ζήτημα του συμβολισμού γενικώς αλλά και ειδικώς αναφορικά με την παρουσία των ανθέων στην Αιγαιακή εικονογραφία. Στο β΄ υποκεφάλαιο αναλύεται ο συμβολικός χαρακτήρας των ανθέων μέσα από εικονογραφικά παραδείγματα. Για λόγους καλύτερης μελέτης του υλικού γίνεται ομαδοποίηση των κατά καιρούς προταθέντων ερμηνευτικών σχημάτων ανά θέμα και ερμηνεία. Στο 7ο Κεφάλαιο επιχειρείται πραγμάτευση του πολυαισθητηριακού φαινομένου στο οποίο μετέχουν τα άνθη στο πλαίσιο τελετουργικών πρακτικών με λατρευτικό ή «κοσμικό» χαρακτήρα. Το 8ο Κεφάλαιο χωρίζεται σε δύο Υποκεφάλαια. Στο α΄ υποκεφάλαιο συζητείται η οικονομική και κοινωνική διάσταση των ανθέων στον Αιγαιακό κόσμο της Εποχής του Χαλκού, ενώ στο β΄ υποκεφάλαιο παρουσιάζονται, αναλυτικά για κάθε άνθος, τα στοιχεία που αφορούν στις ιδιότητες και στις χρήσεις των ανθέων στις Αιγαιακές κοινωνίες της Χαλκοκρατίας. Τέλος, διατυπώνονται τα Συμπεράσματα όπου παράλληλα τίθενται και σχετικά ερωτήματα για την μελλοντική έρευνα.
Exosomes: Mediators of cellular communication in potentially malignant oral lesions and head and neck cancers
Authors: Solomon Monica Charlotte , Chandrashekar Chetana , Kulkarni Spoorti , Shetty Nisha , Pandey Aditi
Published: October 2023

Exosomes are a unique type of extracellular vesicles that contain a plethora of biological cargo such as miRNA, mRNA, long non-coding RNA, DNA, proteins and lipids. Exosomes serve as very effective means of intercellular communication. Due the presence of a lipid bilayer membrane, exosomes are resistant to degradation and are highly stable. This makes them easily identifiable in blood and other bodily fluids such as saliva. The exosomes that are secreted from a parent cell directly release their contents into the cytoplasm of a recipient cell and influence their cellular activity and function. Exosomes can also transfer their content between cancer cells and normal cells and regulate the tumor microenvironment. Exosomes play a vital role in tumor growth, tumor invasion and metastasis. Exosomes provide a multitude of molecular and genetic information and have become valuable indicators of disease activity at the cellular level. This review explores the molecular characteristics of exosomes and the role that exosomes play in the tumorigenesis pathway of potentially malignant oral lesions and head and neck cancers The application of exosomes in the treatment of oral cancers is also envisioned.

Exosomes are very small and can easily pass through various biological barriers, making them very good delivery vectors for therapeutic drugs as well as to selectively induce DNA’s mRNA and miRNAs into targeted cancer cells.
Novel five-phase model for understanding the nature of misophonia, a conditioned aversive reflex disorder
Authors: Dozier Thomas , Mitchell Nathanael
Published: October 2023

Background: Misophonia is a recently identified condition in which a person perceives a subtle stimulus (e.g., eating sounds, hair twirling) and has an intense, negative emotional response. Misophonia cannot be classified with established nosological systems.

Methods: We present a novel five-phase model of misophonia from a cognitive-behavioral framework. This model identifies a learned reflex of the autonomic nervous system as the primary etiology and maintenance of misophonia. Phase one is anticipatory anxiety and avoidance. Phase two is a conditioned physical reflex (for example, the tensing of calf muscles) that develops through stimulus-response Pavlovian conditioning. Phase three includes intense negative emotional responses and accompanying physiological distress, thoughts, urges, and emotion-driven behavior. Phase four is the individual’s coping responses to emotional distress, and phase five is the environmental response and resulting internal and external consequences of the coping behaviors. Each phase helps explain the maintenance of the response and the individual’s impairment.

Results: Anticipatory anxiety and avoidance of phase one contribute to an increased arousal and awareness of triggers, resulting in increased severity of the trigger experience. Both the Pavlovian-conditioned physical reflex of phase two and the emotion-driven behavior caused by the conditioned emotional response of phase three increase with in vivo exposure to triggers. A newly identified feature of phase four is a covert review of the trigger experience. Phase five includes the consequences of those behaviors with internal consequences of beliefs and new emotions (e.g., shame, guilt) based on environmental responses to anger and panic.

Conclusions: We assert the Mitchell-Dozier model provides a novel framework to understanding misophonia as a multi-sensory reflex condition. Our model states that misophonia initially develops as a Pavlovian-conditioned physical reflex and subsequent conditioned emotional responses. Treatments that identify patients’ specific conditioned physical reflex of phase two have shown promising early results, further supporting this model
Logistics and Technical Support Strategy for a Service Enterprise
Authors: Ahmetgareeva A. , Valeeva Yu. , Teterkin A.
Published: October 2023

At present, with the latest events in the world, in particular, the refusal of many foreign companies providing ERP systems, to work in Russia, is increasingly topical consideration of the transition from import accounting systems to domestic products. The article is aimed to consider the theoretical aspects of developing a strategy for the development of the material and technical base of the organization and to develop the application of the studied enterprise on the basis of strategic analysis. The article considers key factors of success, degree of influence on them of political, economic, socio-cultural, technological factors, driving forces of market of products and services 1C, consumer portrait, value proposition to the client, competitive advantage, Strategic management plan, strategic interventions. The following empirical research methods were used - expert survey and questionnaire. The empirical basis of the study was made up of analytical and statistical data on franchising, media materials, Internet resources, results of discussions with specialized specialists in the field of franchising, representatives of franchising companies, information on operating franchising enterprises, own expert data of the author.
Autoimmune encephalitis as a possible reason for psychiatric hospitalisation in the teenage population
Authors: Konopka Anna , Jaz Kamila , Kapłon Kamil , Dylewska Dagmara , Tyszkiewicz-Nwafor Marta
Published: October 2023

Wstęp: Autoimmunologiczne zapalenie mózgu (autoimmune encephalitis - AE) to rzadko występująca choroba, charakteryzujące się m.in. szybko postępującymi zaburzeniami pamięci krótkotrwałej i innych funkcji poznawczych, którym mogą towarzyszyć różnorodne objawy związane z zajęciem układu limbicznego. Pierwsze symptomy AE mogą sugerować występowanie zaburzenia psychicznego, co może opóźniać rozpoznanie i wdrożenie odpowiedniego leczenia. Opis przypadku: 15- letni pacjent został przyjęty do oddziału psychiatrii dzieci i młodzieży ze wstępnym rozpoznaniem ostrych zaburzeń psychotycznych. Prezentował on początkowo omamy wzrokowe i wypowiadał liczne treści o charakterze urojeniowym. Był pobudzony psychoruchowo, skarżył się na kłopoty ze snem i nieustający ból głowy. Badanie neurologiczne wykazało osłabioną siłę mięśniową kończyn górnych. W związku z nietypowym obrazem klinicznym oraz brakiem efektu leczenia przeciwpsychotycznego, u chorego wykonano badania laboratoryjne w tym panel przeciwciał, badanie płynu mózgowo-rdzeniowego oraz rezonans magnetyczny mózgu. Całość obrazu klinicznego przemawiała za rozpoznaniem autoimmunologicznego zapalenia mózgu. W leczeniu zastosowano sterydoterapię, immunoglobuliny i plazmaferezę. Schemat leczenia powtarzano do uzyskania remisji.
Letter to the Editor. Therapy of mental disorders with the use of transcranial magnetic stimulation and the limitations of the method. Commentary on the article Transcranial magnetic stimulation (TMS) in treatment of psychiatric disorders – review of current studies
Authors: Hobot Justyna
Published: October 2023

bez streszczenia
The stress of war. Recommendations for the protection of mental health and wellbeing for both Ukrainian refugees as well as Poles supporting them.
Authors: Zabłocka-Żytka Lidia , Lavdas Michalis
Published: October 2023

Obecność dużej liczby Ukraińców szukających schronienia w Polsce to dla Polaków nowe doświadczenie. Trwająca wojna i niepewność sytuacji przesiedleńców może wywoływać niepokój i prowadzić do reakcji stresowych, potęgowanych nieustającymi informacjami o działaniach wojennych. Dlatego poczucie bezpieczeństwa może być zagrożone nie tylko wśród Ukraińców, którzy uciekli do Polski, ale także wśród osób wspierających Ukraińców, którzy oferują im pomoc i schronienie. Długotrwałe wsparcie, jeśli nie towarzyszy mu odpowiednie dbanie o siebie, może zwiększać ryzyko wypalenia, a także prowadzić do odczuwania trudnych emocji, takich jak poczucie bezradności, beznadziejności, niechęć do dalszej pomocy, a nawet wrogość. W artykule przedstawiono sytuację i aktualne potrzeby psychospołeczne uchodźców ukraińskich w Polsce oraz zaproponowano zestaw zaleceń dotyczących organizacji ochrony zdrowia psychicznego w obliczu toczącej się na Ukrainie wojny. Dostępne są narzędzia, z których mogą skorzystać polscy specjaliści oraz wolontariusze, aby wesprzeć ukraińskich uchodźców. Piramida interwencji dla zdrowia psychicznego i wsparcia psychospołecznego (MHPSS), opracowana przez the Inter-Agency Standing Committee, jest przykładem modelu organizacji ochrony zdrowia psychicznego. Adekwatne wsparcie powinno być dostępne zarówno dla uchodźców, jak i populacji przyjmującej osoby uciekające i wspierające ich.
The position statement of the Working Group on the diagnosis of the post-traumatic stress disorders in adults
Authors: Koweszko Tytus , de Barbaro Bogdan , Izydorczyk Bernadetta , Mastalerz-Migas Agnieszka , Samochowiec Jerzy , Szulc Agata , Kowalska Adrianna , Wachowska Katarzyna , Gałecki Piotr
Published: October 2023

Doświadczenie sytuacji ekstremalnego zagrożenia może prowadzić do poważnych zaburzeń stresowych, które mogą dotknąć zarówno ofiar, jak i osób niosących profesjonalną pomoc. Działania wojenne na terenie Ukrainy w pierwszej połowie 2022 roku zainicjowały trwający kryzys migracyjny, skutkujący przesiedleniem do Polski blisko 3,5 miliona ludzi. Wiele badań wskazuje, że doświadczenie ekstremalnego zagrożenia prowadzi do poważnych zaburzeń stresowych, takich jak zespół stresu pourazowego, który dotyka od jednej trzeciej do połowy dorosłych uchodźców. Ekspozycja na traumatyczny stres związany z napaścią, ograniczeniem podstawowych zasobów, lękiem, niepewnością, śmiercią oraz poczuciem niesprawiedliwości dotknęły całą populację kraju. W rezultacie uchodźcy, pracownicy ochrony zdrowia i służb mundurowych, wolontariusze i pracownicy organizacji pozarządowych stanowią grupę zagrożoną rozwinięciem zaburzeń związanych ze stresem, w tym zespołu stresu pourazowego. Przedstawione stanowisko grupy roboczej zostało opracowane przez interdyscyplinarny zespół ekspertów z obszaru psychiatrii, psychologii klinicznej, psychoterapii i medycyny rodzinnej w celu przedstawienia usystematyzowanych zaleceń dotyczących postępowania diagnostycznego w praktyce lekarskiej i psychologicznej.
Methods of treating gestational diabetes through an adapted diet and physical activity
Authors: Skorek Klaudia , Babiak Rafał , Bajak Karolina , Czuchryta Paulina , Domańska Anastazja , Gawęda Agnieszka , Grabek Agata , Rutkowska Julia , Rzęsa-Tokarczyk Żaneta , Urbańczyk Agnieszka
Published: October 2023

Gestational diabetes mellitus (GDM) is a carbohydrate tolerance disorder that results in elevated blood glucose levels and was first recognized during pregnancy. Diabetes is the most common metabolic complication that complicates pregnancy. Therefore, it is important to quickly diagnose and prevent the effects of diabetes, which may arise in the mother and fetus. The occurrence of diabetes during pregnancy is a risk factor for diabetes and cardiovascular diseases later in life. Studies have shown a reduction in complications in patients with gestational diabetes after personalized health education in the field of nutrition. All pregnant women should be screened for impaired glucose tolerance as soon as possible after pregnancy is diagnosed. In the risk group, additionally, a 75g OGTT test should be performed on the first visit. Gestational diabetes affects one in ten pregnant women worldwide, and this percentage is increasing day by day. The main goal is to strive, during therapy, to equalize the glycemic value. The aim of this publication is to present the diagnostic process and, most importantly, the treatment of diabetes diagnosed in pregnancy. The publication focuses on gestational diabetes treated with an adapted diet, exercise and lifestyle changes. This publication describes how to create a balanced diet with a low glycemic index and how to choose physical exercise for a patient with gestational diabetes.
Burning mouth syndrome - causes and modern treatment methods
Authors: Blicharz Monika , Miazga Dominika , Bartosik-Zielińska Diana , Bartosik Magdalena
Published: October 2023

Introduction and purpose: Burning Mouth Syndrome (BMS) is a chronic painful disorder characterized by a burning or stinging sensation in the oral mucosa. It is a condition that affects a significant portion of the population, and its definition has recently been clarified. BMS can be divided into primary (idiopathic) or secondary forms, depending on the presence or absence of an identifiable cause.

Brief description of the state of knowledge: Currently, it is estimated that BMS affects 1 in 1000 people, with women over the age of 60 being particularly susceptible. The exact causes of BMS are not well understood, but research suggests they may have a multifactorial nature, involving neuropathic, endocrinological, and psychosocial factors. BMS symptoms include oral burning, taste disturbances, dry mouth, tingling, and numbness of the tongue. Patients often experience burning sensations on the tongue, palate, gums, lower lip, and throat. In addition to physical symptoms, the condition can lead to sleep disturbances, health problems, and psychological disorders. Diagnosing BMS is challenging and time-consuming. A physician must rule out other causes of symptoms, such as oral infections or nutritional deficiencies. A detailed medical history, intraoral examination, and laboratory tests are necessary for diagnosis. Treating BMS requires the collaboration of multiple specialists, including neurologists, dentists, orofacial pain specialists, and psychologists.

Summary: Burning Mouth Syndrome remains poorly understood in terms of its causes and treatment. Patients often experience not only physical discomfort but also psychological issues such as depression and anxiety. Treatment is challenging and often does not provide complete relief. Continued research into this condition is crucial to better understand its nature and find more effective treatment methods.

Keywords: BMS, Burning Mouth Syndrome, stomatodynia
REVIEW OF COUNTER-TERRORISM SYSTEMS DURING SUMMER OLYMPIC GAMES IN THE 21ST CENTURY
Authors: Michalski Daniel , Radomyski Adam Marek , Bernat Paweł
Published: October 2023

The research results presented in the article pertain to the organization of security systems by the host countries during the Summer Olympic Games in Athens (2004), Beijing (2008), London (2012), and Rio de Janeiro (2016). The central part of the considerations focuses on the complex issue of searching for methods and tools to effectively protect participants of such large mass sports events, not only against terrorists. Taking into account the identified problem situation, it was agreed that the aim of the article will be to characterize the security methods and tools employed by the organizers of the Summer Olympic Games. The research was conducted with the use of selected theoretical scientific methods, including analysis, synthesis, comparison, analogy, generalization, and inference. These methods were applied in a structured way to a research process that focused on case studies of selected Summer Olympic Games that were considered representative samples. The results of the carried out research clearly indicate a high complexity of the security systems created for the needs of the Olympic Games. In every analyzed case, the need occurred to integrate state institutions and international organizations, including various agencies dealing with security issues, including terrorism.
Additionally, based on the obtained results, it was also determined that properly forecasting threats is crucial in ensuring the safety of participants in the Olympic Games. It should be further emphasized that in each analyzed case study, the organizers of these large sports events fulfilled their role as hosts very well. They should, therefore, be recognized as a good example for other countries that will apply for organizing this type of mass sports events in the future. They must also be aware that each sporting event of this type requires a significant organizational and financial effort and that the threats are not limited to terrorism but can be posed by various external and internal factors.
This article is one of the first attempts to assess the justification of implementing various methods and tools to the security systems of mass international sporting events through the prism of their effectiveness. In addition, the proposed solutions, including the threat forecasting methodology, may be useful to both practitioners and theoreticians in creating more effective solutions in the field of national and international security.
EUROPEAN UNION AT THE DAWN OF TECHNOLOGICAL COLD WAR
Authors: Gajewski Tomasz
Published: October 2023

The purpose of the study was to construct a picture of the EU’s global position in a world defined by the US-Chinese technological Cold War. Morphological analysis has been used to enable a comprehensive analysis of the relationship between the technological and social domains. Structured interviews were also used to support the analytical process. The results of the exploration showed a picture of the EU’s multi-level technological weakness compared to competing powers. While the EU is not a weak entity, its future international position will depend on the creation of its own technological capabilities and on cooperation with the United States. Both lines of action are subject to multiple risks. Firstly, some aggressive technological developments (such as the plans to place microchips production in Europe) can generate more problems than diversification. Secondly, the EU must extend its work on high-tech (primarily AI) beyond the logic of market regulation and focus on their geopolitical and military dimension. It must also be ready for possible obstacles in cooperation with the United States. The alternative to this track, as the analysis shows, is the technological, and hence the political and economic peripheral status, where two technological superpowers – the United States and authoritarian China will compete. The most negative result for the EU is the status of “digital colony”. The paper aspires to be a part of the effort to fill the existing void in the scientific output of Polish social sciences, regarding exploration of the geopolitical dimension of technological progress, especially its impact on EU’s position in the new power distribution model, which will be the result of the rivalry between the US and China.
El concepto de democracia plebiscitaria en Max Weber (1919/1920)/Max Weber's Concept of Plebiscitary Democracy (1919/1920)
Authors: Abellán García Joaquín
Published: October 2023

El artículo analiza los dos únicos escritos en los que Max Weber emplea la expresión democracia plebiscitaria, en 1919/1920, y muestra dos cosas: 1) el fenómeno al que Max Weber denomina democracia plebiscitaria, que no es sino la modernización de los partidos políticos como consecuencia de la extensión del sufragio electoral (de acuerdo con una afirmación del propio autor, usualmente ignorada); 2) la ubicación de la democracia plebiscitaria dentro de la tipología weberiana de los tipos de poder legítimo. Sobre esta base se concluye que la democracia plebiscitaria no es para Max Weber una forma de Estado o de gobierno, que suele ser, sin embargo, la suposición con la que se ha operado habitualmente en la interpretación del mencionado concepto. Visto desde la perspectiva de la historia conceptual éste es el caso de una palabra a la que se le ha asociado posteriormente un contenido semántico que el propio autor no le había atribuido
El espejo enterrado. Una biografía de nuestra cultura/The Buried Mirror: a biography of our culture
Authors: Weinberg Liliana
Published: October 2023

El espejo enterrado (1992) ocupa un lugar clave en la producción ensayística del escritor mexicano Carlos Fuentes y lo confirma como uno de los más notables intelectuales de nuestro tiempo. La obra y la serie documental a ella vinculada se reprodujeron ampliamente para contribuir a la reflexión en torno al significado de los quinientos años del primer viaje de Colón a través del Océano Atlántico, así como también para pensar la posibilidad de una comunidad iberoamericana apoyada en una historia, una lengua, una tradición cultural y un imaginario compartidos. Este ensayo de interpretación de la vida de América y España se piensa a su vez como una biografía de nuestra cultura y una autobiografía intelectual del propio autor. Fuentes encontró en un año tan significativo como 1992 una oportunidad dorada para escribir la biografía de una cultura que consideró unida por el que llamó “territorio de La Mancha”, repensar la relación entre España y América y emprender una nueva valoración de su perfil, su destino y su aporte al concierto de las naciones en una nueva etapa del orden mundial. Tiempo, lenguaje e imaginación: la historia se toca con la biografía y el análisis de los datos se toca con la recreación narrativa, a la vez que la relectura de la relación entre lengua, historia y cultura alimentadapor el análisis de imágenes y documentos no sólo permiten al intelectual dar cuenta de una experiencia compartida sino además interpretar su propia vida a la luz de la vida de nuestra cultura.
El arte de vivir ecológico/The art of ecological living
Authors: Schmid Wilhelm , Ordóñez Roig Vicente
Published: October 2023

El problema ecológico no es nuevo; ha acompañado toda la historia reciente de la humanidad. Sin embargo, lo que es nuevo es el alcance que ha tenido desde la modernización tecnológica e industrial de los siglos XIX y XX y que, si los indicios y la información no son engañosos, amenaza con convertirse en un desastre para toda la humanidad en el siglo XXI. El informe de la ONU de la Conferencia sobre el Cambio Climático, del año 2007, y recientemente el desastre nuclear de Fukushima aportan evidencias en esta dirección. ¿Cómo se llegó a esa problemática, cómo evolucionó el saber al respecto y cómo se deja justificar convincentemente la actuación humana y social? ¿Qué puede hacer un individuo para proyectar una vida más sostenible? ¿Qué es el Antropoceno? ¿Es posible construir una sociedad ecológica y solidaria? Estas y otras preguntas se abordan desde la reflexión filosófica en el presente artículo.
The laicity of the State and its challenges/A laicidade do Estado e seus desafios
Authors: Fischmann Roseli
Published: October 2023

The definition of the relationship between the State and religions is part of the legal order of the countries, indicating whether the State is laic and must be kept separate from all religions, or if an official religion is attributed to it, or if it is a theocratic State. This article is based on qualitative, historical, bibliographical and documental research. It seeks to offer a contribution to a better understanding of the theme of the laicity of the State. It focuses on the case of Brazil, specifically with regard to the Brazil-Holy See Agreement (or Concordat), signed in November 2008 at the Vatican
Conservadurismo y pensamiento reaccionario en Colombia: a propósito de la obra de Nicolás Gómez Dávila / Conservatism and reactionary thought in Colombia: a review of the work of Nicolás Gómez Dávila
Authors: Uribe López M. , Piedrahíta Ramírez L.F. , Sánchez Marín L.
Published: October 2023

El auge de los populismos de extrema derecha en el último tiempo amerita una indagación acerca de las características de la ideología reaccionaria. Una forma de aproximarse a esta es a través del pensamiento de sus principales autores. Nicolás Gómez Dávila es el mejor representante del pensamiento reaccionario en la filosofía latinoamericana, de modo que, a partir del análisis de algunos de sus escritos y siguiendo la propuesta de Richard Shorten para identificar lo reaccionario con base en tres pilares retóricos: decadencia (logos), conspiración (ethos) e indignación (pathos), este artículo enfatiza algunas características propias de la ideología reaccionaria que la distinguen del conservadurismo, ilustrando esas diferencias con la retórica de algunos líderes reaccionarios que antecedieron a Nicolás Gómez Dávila en la Colombia del siglo XX.
La Germania de Tácito. Una alteridad al servicio del imperialismo romano/Tacitus' Germania. An otherness at the service of Roman imperialism
Authors: Díaz Martínez Pablo C.
Published: October 2023

La lectura de la Germania ha pasado por avatares diversos, procedentes tanto de las propias proyecciones del presente como de la naturaleza imprecisa del texto. Su ‘imperfecta’ etnografía provocó una minusvaloración que llevó a ignorar la intencionalidad política subyacente al discurso erudito. Sin embargo, presentar el texto como una mera descripción, o el divertimento académico de un estudioso, contradice la incuestionable implicación pública de su autor. Tácito es un genuino representante de una facción senatorial que, además de añorar el pasado, pretende influir en la política imperial, promover un impulso expansionista que la lógica estratégica defensiva parecía ya desaconsejar
Explorando el discurso de enfermos crónicos sobre la legalización de la muerte médicamente asistida
Authors: Ordóñez Vázquez Norma Alicia
Published: October 2023

Introducción: Las enfermedades crónicas van en aumento, y conllevan múltiples consecuencias que en un determinado momento, con el paso de los años, puede llegar a un estado terminal de la enfermedad. Es importante conocer la visión de estos enfermos sobre la muerte médicamente asistida. 

Objetivo: Conocer y analizar el discurso de enfermos crónicos sobre la  muerte digna, la eutanasia y el suicidio médicamente asistido para visibilizar la necesidad de la regulación de la muerte digna.

Método: Se realizó una investigación cualitativa que se inserta dentro del paradigma del construccionismo social. Se llevaron a cabo entrevistas utilizando una guía semiestructurada. Se utilizó el análisis del discurso para encontrar convergencias y diferencias en los discursos.

Resultados: Se entrevistaron siete participantes que padecen una enfermedad crónica. Los discursos convergen hacia una muerte digna sin dolor, sufrimiento, tranquila y en casa. Coinciden sus discursos en legalizar la eutanasia y el suicidio médicamente asistido; sin embargo, algunas difieren en cuanto a solicitarlas. Las experiencias previas de muerte de sus seres queridos es un factor que influye para desear una muerte digna.  

Discusión y conclusiones: La experiencia de la enfermedad crónica es un factor importante para aceptar en un futuro la muerte médicamente asistida, si ser una carga para otros y evitar el dolor y sufrimiento al final de la vida. La religión influye en las decisiones, pero se puede observar una mayor apertura para aceptar la legalización de la muerte médicamente asistida.

Palabras clave: enfermedad crónica, muerte digna, eutanasia, suicidio médicamente asistido, análisis del discurso.
When Variety Seeking Meets Unexpectedness: Incorporating Variety-Seeking Behaviors into Design of Unexpected Recommender Systems
Authors: Li Pan , Tuzhilin Alexander
Published: October 2023

In this paper, we study the consumers’ variety-seeking behavior in recommender system applications and propose a comprehensive framework to measure such behavior based on past consumption records. The effectiveness of the proposed framework is validated through user questionnaire studies conducted at Alibaba, where our constructed variety-seeking measures match well with consumers’ self-reported levels of their variety-seeking behaviors. We subsequently present a recommendation framework that combines the identified variety-seeking levels with unexpected recommender systems in the data mining literature to address consumers’ heterogenous desire for product variety, in which we provide more unexpected product recommendations to variety-seeking consumers and vice versa. Through off-line experiments on three different recommendation scenarios and a large-scale online controlled experiment at a major video-streaming platform, we demonstrate that those models following our recommendation framework significantly increase various business performance metrics and generate tangible economic impact for the company. Our findings lead to important managerial implications to better understand consumers’ variety-seeking behaviors and design recommender systems. As a result, the best performing model in our proposed frameworks is deployed by the company to serve all consumers on the video-streaming platform.
Is Financial Management Mediating the Role of Love of Money and Human Resources Competence in Explaining MSMEs’ Performance?
Authors: Herawaty Netty
Published: October 2023

This study aims to analyze the role of financial management in mediating the impact of the love of money and human resource competence on MSMEs’ performance. It used primary data gathered from 143 respondents through a direct survey. The respondents were the owners of culinary MSMEs in the City of Jambi that were selected based on a cluster sampling method to represent all types of culinary MSMEs. Six hypotheses were formulated to achieve the aim of the study. Path analysis based on multiple regression and Sobel tests were applied to test the hypotheses. The analysis results show that human resource competence affects financial management and impacts MSMEs’ performance directly and indirectly. On the other hand, love of money did not impact financial management. It did not impact MSMEs’ performance either directly or indirectly. Thus, this study provides a piece of evidence for financial management as a mediating variable between human resources competence and MSMEs’ performance.
Legal responsibilities relating to isolation
Authors: Finch John
Published: October 2023

Isolation can cause harm in everyday life, even in the most benign conditions. Taking on responsibility for a patient in the community who is isolated can entail a responsibility to steer them on a course, which they might otherwise not have taken and which might redound to their benefit. In this article, John Finch, a freelance journalist specialising in clinical law and ethics, examines some of the legal responsibilities which are added by the effects of isolation to the already heavy burden carried by community nurses.
Why are some people susceptible to Super-Helper Syndrome and what can be done about it?
Authors: Baker Jess , Vincent Rod
Published: October 2023

Chartered Psychologists Jess Baker and Rod Vincent coined the term Super-Helper Syndrome as a useful moniker for the net effects of compulsive helping and not meeting one's own needs—where helping others is to the detriment of one's own wellbeing. Together, they have written an award-winning book that includes excerpts from their qualitative research to offer insights into this common phenomenon that until now has gone unexplored. In this article, the authors provide an overview of Super-Helper Syndrome and why some people are more susceptible to it than others. They describe the range of practical interventions that have been most successful in ameliorating its harmful effects.
Why breast milk matters
Authors: De Boer Rachel , Gray Denise , Harris Gillian , Sahota Pinki , Singhal Atul , Upton Lucy
Published: October 2023

Midwives understand the benefits of breastfeeding, both for the infant and mother. However, the biochemical and physiological reasons for the superiority of breast milk are less widely known. This is, in part, because of the extraordinary complexity of breast milk's composition. Its key components include nucleotides, which benefit gut and immune development, human milk oligosaccharides, which promote an optimal gut biome, lipids in the milk fat globule membrane, which promote gut health and brain development, immunoglobulins, which modulate the infant's immune system, and an optimum protein content, which is high in the first 2 weeks after birth but decreases thereafter. A greater awareness and understanding of the mechanisms behind the benefits of breastfeeding could help midwives to have informed discussions with parents and potentially contribute to improving the UK's breastfeeding rates. Growing understanding of breast milk's unique composition may also help infant formula manufacturers drive innovation and improve the formulation of their products.
Mass casualty triage: using virtual reality in hazardous area response teams training
Authors: Thompson Steven
Published: October 2023

Background:

In recent years, virtual reality (VR) has become a pedagogic resource that complements the general training health professionals receive. VR could revolutionise hazardous area response team (HART) mass casualty incident (MCI) triage training.

Aims:

The study aimed to establish whether VR could improve the overall effectiveness of HART triage training and increase practitioner confidence and preparedness for an MCI.

Methods:

The author co-developed a VR marauding terrorist attack (MTA) triage scenario at a football stadium. The software was loaded onto Oculus Quest 2 VR headsets. HART paramedic participants completed an online survey before the exercise, which focused on demographics and experience. They were then familiarised with the VR equipment, which incorporated a tutorial on patient interaction. This was followed by a VR MTA exercise with 15 casualties, after which they completed an online survey to gauge their opinions.

Results:

All 36 HART paramedics recruited agreed VR would improve the effectiveness of HART paramedic training for mass casualty triage. Furthermore, 30 (83%) agreed that VR was more effective than the sand manikins currently used in training. Following the VR scenario, 31 (86%) of participants reported increased confidence in responding to an MCI and carrying out mass casualty triage.

Conclusion:

VR can improve the effectiveness of the HART triage training and may increase HART paramedic confidence in responding to an MCI and carrying out primary triage. Further studies with larger samples could determine if the results from this study can be generalisable across all frontline paramedic clinicians. Additionally, participant accuracy and time on task data should be evaluated.
Gastrointestinal morphology and feeding intensity of Periophthalmus gracilis caught from some coastal provinces in the Mekong Delta, Vietnam
Authors:   Institute of Food and Biotechnology, Can Tho University, Can Tho 900000, Vietnam, Van Hua U ,   Department of Biology, Hoang Dieu High School, Soc Trang 950000, Vietnam, Quang Minh Dinh ,   Department of Biology, School of Education, Can Tho University, Can Tho 900000, Vietnam, Nguyen Ton Huu Duc ,   Department of Biology, School of Education, Can Tho University, Can Tho 900000, Vietnam
Published: October 2023

This study provided data on gastrointestinal morphology and feeding intensity of slender mudskipper Periophthalmus gracilis distributed in some coastal provinces in the Mekong Delta, Vietnam (VMD). Fish specimens were sampled monthly by hand-catching, from 01/2022 to 12/2022, in four provinces in the VMD: Tra Vinh, Soc Trang, Bac Lieu, and Ca Mau. After sexing, the fish total length and weight, gut length, and gastrointestinal morphology were measured and described. The study showed that Periophthalmus gracilis had a protruding upper jaw with a longer upper jaw bone length. The teeth are large and sharp, with pointed molars and unevenly distributed in a row on the upper jaw. The tongue was short and had a round tip. The gastrointestinal had an elastic tube-shaped esophagus, a short sac-shaped stomach, and long, straight, curving tube intestines. The feeding intensity of the mudskipper varied by season and month, with differences between males and females. These findings provided new information on the mudskipper’s gastrointestinal morphology and feeding habit.