bluuebunny/crossref_metadata_2025 huggingface dataset:
Modification of Heterocycles by Amidoalkylation
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991 Russia, Gorunova O. N.
Published: September 2021

The functionalized derivatives of heterocyclic compounds find extensive application in medicine, agriculture, and many fields of chemistry as precursors for more complex products that display remarkable biological and catalytic activities. A whole range of different heterocycles can be obtained by intra- or intermolecular amidoalkylation. This review presents the examples of successful application of the reactions of C-amidoalkylation, in particular, enantioselective reactions for the modification of heterocycles and outlines the prospects of their further application.
Evaluation of antibacterial potentials of Parthenium hysterophorus L. leaf extract against some pathogenic and nonpathogenic bacteria
Authors: Kallol M. A. , Pinky N. J. , Asaduzzaman  , Das B. K. , Rahman M.
Published: September 2021

Background: The herb, P. hysterophorus L. has been used in folk medicine for many years to treat neurological disorders, inflammation, fever and malaria. This study aimed to evaluate the antibacterial activity of P. hysterophorus L. leaf extracts against some pathogenic and nonpathogenic bacterial strains. Methods: Methanol and chloroform extracts of P. hysterophorus L. leaf were applied against pathogenic Vibrio (V.) parahaemolyticus ATCC 17802, Escherichia coli 0157 ATCC 43894, Sarcina (S.) lutea IFO 3232) and nonpathogenic Bacillus (B.) subtilis IFO 3026 strains by agar well diffusion assay. Visible zones of inhibition were measured. Results: The methanol and chloroform extracts of P. hysterophorus leaf exhibited remarkable antibacterial activity against all three pathogenic (V. parahaemolyticus, E. coli 0157, S. lutea) and nonpathogenic (B. subtilis) bacterial strains. Chloroform solvent extract of P. hysterophorus leaves showed highest zone of inhibition (23 mm) against gram positive pathogenic S. lutea and methanolic leaf extract showed highest zone of inhibition (26 mm) against B. subtilis. The lowest zone of inhibition was observed for gram negative pathogenic V. parahaemolyticus in the response of methanolic (9 mm) and the chloroform (10mm) leaf extract. Conclusion: The findings of this study suggest that, leaf extracts of Parthenium hysterophorus L. could be a potential source of antibacterial agents to cope with antibiotic resistance and new drug discovery.
IMPLEMENTASI NILAI-NILAI PENDIDIKAN ISLAM DALAM AKTIVITAS REMAJA MASJID IMAM RIJALI IAIN AMBON
Authors: Walalayo Sadila Salma
Published: September 2021

Abstract: The result of this study that the from of the Rijali IAIN Ambon Imam mosque youth programs that contains, the value of Islamic education is . 1). Preaching or preachers programs, Islamic studies programs, Community comford programs, Cooperative programns and government programs. This programs was formed by means of deliberations between the chairman of the Takmir mosque, the youth of the mosque, and other members. 2). Activities that contain the value of Islamic education including for women there are certain assignments including: a). cleaning the veil, b). reviewing women’s jurisprudence studies, c). training young preachers training, d). lecturing training, e). tahlil training, f). yasinan, g). cult before zhuhur prayer as well as Islamic studies, and big day celebrations Islamic. The implementation of Islamic values contained in the activities of the youth of the Imam Rijali IAIN Ambon mosque itself includes character formation, monotheism, worship n the morals. Islamic values are implemented through the program activities that exist in the youth mosque the Imam of the Ambon. Including the student component itself which was fully supported by the head of the mosque’s takmir Rijali IAIN Ambon.

Keywords: Implementation of Islamic values, Adolescent mosque.

Abstrak: Hasil penelitian ini bahwa bentuk program Remaja Masjid Imam Rijali IAIN Ambon adalah, 1). Program dakwah atau mubaligh, Program kajian keIslaman, Program kenyamanan umat, Program koperasi dan Program keputrian. Program-program ini dibentuk dengan cara bermusyawarah antara ketua takmir masjid, ketua remaja masjid dan para anggota lainnya. 2). Aktivitas yang mengandung nilai pendidikan Islam diantaranya untuk para akhwat ada tugas-tugas tertentu antara lain: a).Pembersihan mukena-mukena,b).Kajian - kajian fiqih wanita, c). Pelatihan-pelatihan mubaligh-mubaligh muda, d). Pelatihan ceramah, e). Pelatihan tahlil, f). Yasinan, g). Kultum sebelum shalat zhuhur serta kajian-kajian keIslaman, dan perayaan hari-hari besar Islam. Implementasi nilai-nilai Islam yang terdapat dalam aktivitas remaja masjid sendiri yaitu meliputi pembentukan karakter, ketauhidan, ibadah serta akhlak. Nilai-nilai Islam itu di terapkan melalui aktivitas program yang ada di Remaja Masjid Imam Rijali IAIN Ambon tersebut. Dengan adanya implementasi nilai-nilai Islam ini sangat mempengaruhi bagi remaja masjid termasuk didalamnya komponen mahasiswa itu sendiri yang sepenuhnya mendapat dukungan ketua takmir masjid.

Kata kunci: Aktivitas Remaja Masjid, Nilai-Nilai Pendidikan Islam
PERANCANGAN LOGO DAN DESAIN KEMASAN COOKYE COOKIES SEBAGAI IDENTITAS VISUAL
Authors: Permatasari Ervina Indah , Rahmadianto Sultan Arif , Sukmaraga Ayyub Anshari
Published: September 2021

Sektor industri makanan & minuman di Indonesia cukup banyak dan berkembang, sehingga banyak pula UMKM yang memulai menggambil peluang bisnis makanan dan minuman dikarenakan meningkat cukup pesat. Semakin berkembangnya jaman banyak pula bermunculan inovasi dalam pembuatan produksi makanan. Berbagai jenis makanan mulai dari makanan berat hingga makanan ringan sebagai pelengkap telah banyak melalui perkembangannya. Dessert merupakan salah satu makanan ringan yang cukup memiliki banyak varian rasa dan jenis seperti Cookye Cookies, dimana usaha rumahan ini memproduksi jenis kue kering dan soft cookies. Soft cookies yang diproduksi cukup unik dengan varian rasa yang ditawarkan, namun sebagai perusahaan makanan yang ingin berkembang Cookye Cookies belum memiliki identitas visual sebagai ciri dari perusahaannya. Perancangan untuk pembuatan logo, desain kemasan dan sosial media instagram karena era serba digital saat ini dapat membantu produk Cookye Cookies semakin dikenal oleh konsumen. Metode pengumpulan data dengan observasi dan wawancara, untuk metode perancangan dalam tugas mengunakan metode kualitatif, pada analisis data menggunakan teknik analisis SWOT. Perancangan digunakan agar data yang terkumpul digunakan sebagai acuan membuat konsep visual. Hasil akhir yang didapat berupa logo sebagai identitas visual, desain kemasan primer dan sekunder, foto untuk instagram, dan merchendise berupa tumbler, tote bag, dan t-shirt.
PERANCANGAN ANIMASI 2D ASAL USUL REOG PONOROGO ADAPTASI CERITA RAKYAT SEBAGAI UPAYA PELESTARIAN BUDAYA INDONESIA
Authors: Wijaya Patricia Abigail , Rahmadianto Sultan Arif , Nugroho Didit Prasetyo
Published: September 2021

Perkembangan teknologi telah membawa perubahan dalam berbagai aspek, salah satunya media pembelajaran dan hiburan. Cerita rakyat yang merupakan salah satu budaya literatur Indonesia, mulai kurang diminati dengan adanya bermacam budaya lain yang masuk ke Indonesia. Upaya pelestarian perlu dilakukan karena cerita rakyat mengandung nilai-nilai moral dan budaya yang baik, khususnya bagi anak-anak. Perancangan ini mengadaptasi cerita rakyat “Asal Usul Reog Ponorogo” dalam bentuk animasi 2D, sebagai video edukatif yang menghibur mengenai salah satu cerita rakyat kurang diketahui oleh anak-anak. Metode penelitian dilakukan secara kualitatif dengan pengumpulan data yang berupa studi pustaka terhadap kesenian reog ponorogo, dan observasi serta wawancara terhadap anak-anak sekolah dasar. Observasi dan wawancara dilakukan untuk memperoleh data ketertarikan anak terhadap cerita rakyat dan animasi. Analisis data dilakukan dengan metode 5W+1H untuk memperoleh suatu sintesis dan konsep yang mendasari perancangan. Produksi perancangan animasi dimulai dari pembuatan alur, naskah, desain karakter dan background, storyboard, animatic, animation, coloring, dan kemudian post-production. Animasi 2D yang dihasilkan berdurasi 4 menit dan detik dengan audio berupa musik, sound effects, dan voice over. Perancangan ini didukung dengan beberapa media yaitu, video teaser, poster, serta merchandise yang berupa gantungan kunci.
PERANCANGAN KONTEN VISUAL SEBAGAI MEDIA PROMOSI PADA SOSIAL MEDIA INSTAGRAM KAFE REGINA DI KABUPATEN TULUNGAGUNG
Authors: Paskalina Anastasia Jovita , Nirwana Aditya , Nugroho Didit Prasetyo
Published: September 2021

Dengan adanya peningkatan pembangunan kafe di area Jawa Timur khususnya Kabupaten Tulungagung, kompetitor semakin meningkat sehingga mengharuskan para pemilik usaha kafe memiliki kreatifitas untuk mempromosikan bisnis mereka kepada target audiens yang dituju. Maka dari itu, peran fotografi dan videografi berpengaruh besar dalam mempromosikan sebuah bisnis agar dapat menarik minat target audiens dan terlihat lebih meyakinkan untuk dijual. Konsep fotografi yang diangkat yaitu fotografi makanan dan landscape, kemudian konsep videografi menggunakan teknik berupa B-Roll dan cinematic, hasil dari perancangan di unggah pada sosial media Instagram @reginakopii yang memiliki tujuan untuk mempromosikan kafe Regina kemudian menggunakan jasa Instagram ads untuk memperluas promosi di sosial media. Metode perancangan ini menggunakan data primer dan data sekunder yang dalam pengumpulan datanya menggunakan metode kualitatif. Kesimpulan dari perancangan yaitu mendapatkan hasil visual berupa kumpulan foto – foto makanan dan 2 video yang mengusung tema profil kafe. Perancangan ini juga didukung oleh beberapa media pendukung seperti sosial media Instagram, t-shirt, masker, totebag, sticker, dan gantungan kunci akrilik.
PERANCANGAN MOTIF SATWA ENDEMIK INDONESIA PADA PRODUK FASHION SEBAGAI GERAKAN KEPEDULIAN SATWA MELALUI GAYA HIDUP
Authors: Sari Belinda Carlita
Published: September 2021

Indonesia menjadi negara dengan peringkat keenam dalam hal kepunahan biodiversitas alamnya termasuk satwa – satwa endemik yang hanya bisa ditemukan di Indonesia. Hal tersebut dikarenakan banyaknya ekploitasi dan kurangnya rasa peduli masyarakat terhadap keberadaan satwa endemik tersebut. Tujuan dirancang motif dengan mengangkat tema satwa endemik ini adalah sebagai suatu gerakan kepedulian satwa khususnya satwa endemik melalui gaya hidup yaitu dengan berpenampilan atau menggunakan produk fashion, seperti kaos, topi, sandal, sepatu dan tas. Metode yang digunakan dalam perancangan ini pertama-tama dengan pengumpulan data dengan mencari berbagai referensi desain motif satwa dan penerapannya, kemudian yang kedua menganalisis data dan mendapatkan hasil visualisasi desain. Hasil dari rancangan ini berupa 14 motif satwa endemik Indonesia yang berupa motif tanpa batas yang dapat diaplikasikan terutama pada media yang dapat dicetak dan dibentuk menjadi produk fashion seperti kaos, topi, tas, sepatu, sandal, masker dan case hp. Dari hasil perancangan ini diharapkan produk fashion yang dihasilkan dapat digunakan sehari hari, dengan demikian maka masyarakat akan lebih mengenal, lebih peduli akan kelestarian hewan edemik Indonesia.
Postural Stability Change Under Sleep Deprivation and Mental Fatigue Status
Authors: Cheng Shan , Yang Jinghua , Su Miao , Sun Jicheng , Xiong Kaiwen , Ma Jin , Hu Wendong
Published: September 2021

AbstractBACKGROUND: Based on posturography parameters during sleep deprivation (SD), a mental fatigue index (MFI) was constructed for healthy male cadets.METHODS: There were 37 young male subjects who volunteered for two successive days of SD. Their posturography
balance, profile of mood status (POMS), and heart rate variability (HRV) were measured at four different times (10:00 and 22:00 of day 1, 10:00 and 22:00 of day 2). According to the methods used in our previous research, similar MFIs based on posturography parameters were computed. Then, correlations
of MFIs with POMS scores and HRV values were evaluated by linear and nonlinear methods including quadratic, S-curve, growth, and exponential analyses.RESULTS: MFI continued to increase during SD and MFI as the independent variable had quadratic relationships with fluster (R2
0.057), depression (R2 0.067), and anger (R2 0.05) scores of POMS. A linear correlation was found between MFI and the depression score (R2 0.045) and MFI correlated linearly (R2 0.029) and nonlinearly (R2 0.03) with heart rate. Similarly,
MFI reflected changes in the time and frequency domain parameters of HRV, with linear (R2range: 0.0290.082) or nonlinear (R2range: 0.0300.082) relationships.DISCUSSION: The increase of MFI was linked with amplification of personal negative moods and an imbalance
of autonomic nervous system activity. The findings suggest that MFI might be a potential indicator of mental fatigue and provide a method to prevent driving fatigue and human errors.Cheng S, Yang J, Su M, Sun J, Xiong K, Ma J, Hu W. Postural stability change under sleep deprivation
and mental fatigue status. Aerosp Med Hum Perform. 2021; 92(8):627632.
IMPLEMENTATION OF DEMONSTRATION METHODS IN IMPROVING TEACHERS' PEDAGOGIC COMPETENCE DURING THE COVID-19 PANDEMIC AT SLB MELATI RUMBAI
Authors: Maidar Maidar
Published: September 2021

Based on the observations, there are irregularities in the teacher's ability to teach. This can be seen from the symptoms, among others, There are still teachers who are not able to develop a learning syllabus, they only use the old syllabus, There are still those who have not been able to manage the class properly and properly, There are still teachers who have not been able to interact and communicate well with students., There are still teachers who have not been able to allocate time properly. There are still teachers who do not motivate students to be actively involved in the learning process. This study aims to determine whether the teacher's pedagogical competence can be improved by using the demonstration method at SLB Melati Rumbai Pekanbaru City. Based on the background description, problem identification and problem limitation, the focus of this research relates to the Implementation of the Demonstration Method in Improving Teacher Pedagogic Competence during the Covid-19 Pandemic at SLB Melati Rumbai Pekanbaru City. This School Action Research was carried out only at SLB Melati Rumbai Pekanbaru City. This research was conducted in two cycles. The duration of this research is approximately 1 month. From the description of data processing and discussion, it was concluded that the teacher's pedagogic competence was obtained in the first cycle of 65% in the good category and in the second cycle increased to 87% in the very good category.
Formation of mathematical education and science at the Belarusian State University (1919–1920s)
Authors: Yanouski Aleh A.
Published: September 2021

On the basis of archival materials and other sources, the complex process of formation at the Belarusian State University of mathematical education and scientific research in various fields of science is considered. Particular attention is paid to the years that did not stop in 1919–1921 discussions among officials and scientists about the legality of creating a separate mathematics faculty specifically for the opening of the Belarusian State University. In this case, for the first time, the position of an outstanding mathematician and organiser of mathematical education, a native of Belarus, I. R. Braitsev, is presented in detail. The author defines the 1920s as an undoubtedly significant stage not only in the formation of the mathematical component in the general character of Belarusian State University, but also in the formation of the foundations of the future high level of university mathematics.
Pelatihan dan Pendampingan Peningkatan Keahlihan Modelling Character 3D untuk Siswa dan Guru di SMK ST. FRANSISKUS SEMARANG
Authors: . Muslih , Susanto Ajib , Muqoddas Ali , P. Elkaf Rahmawan , Soeleman M. Arief
Published: September 2021

Perkembangan saat ini teknologi informasi dan komunikasi (TIK) berjalan sangat begitu cepat yang diiringi dengan perkembangan bidang lainnya seperti teknologi telekomunikasi, termasuk juga pada jaringan komputer dan aplikasi 3D, seperti saat ini yang sedang ada wabah virus Corona (Covid-19) informasi dengan 3D sangatlah membantu. Kurikulum di SMK dengan DUDI (dunia usaha dan industri) diselaraskan agar lulusan SMK dapat siap pakai dengan lapangan pekerjaan yang tersedia. Tujuan pelatihan dan pendampingan agar Guru dan siswa dapat meningkatkan keahlian modelling character 3D di lingkungan Sekolah Menengah Kejuruan (SMK) ST. Fransikus Semarang. Implementasi kegiatan dengan melakukan pelatihan dan pendampingan melalui virtual secara bertahap dengan memberikan contoh dana penugasan modelling character 3D sehingga hasil karya multimedia lebih interaktif dan menarik.
PENDAMPINGAN MANAJEMEN PRODUK UMKM “TAHU BAROKAH” MADIUN
Authors: Wardoyo Putro Prima Utama , Sulistiyowati Liliek Nur , Asmike Metik
Published: September 2021

Perkembangan dunia modern menciptakan tekanan yang besar terhadap pelaku usaha dewasa ini, tak terkecuali Usaha Mikro Kecil Menengah (UMKM). Perubahan teknologi, budaya, dan arus informasi yang cepat menciptakan kompetisi pasar yang begitu hebat. Hal ini cukup berdampak terhadap daya saing UMKM yang memiliki keterbatasan dari segi teknologi, informasi, dan akses ke dunia luar. Salah satu UMKM yang merasakan dampak ini adalah UMKM Tahu Barokah yang berada di Kota Madiun. Keterbatasan pengetahun terhadap perkembangan dunia modern membuat UMKM yang memproduksi olahan tahu ini semakin sulit bernafas ditengah persaingan yang begitu ketat. Pelaksanaan pengabdian masyarakat ini menyasar pelaku usaha Tahu Barokah di Kota Madiun. Dalam pelaksanaan kegiatan ini, difokuskan pada manajemen produk yang meliputi: pengemasan produk yang bisa meningkatkan daya Tarik produk, manajemen pengolahan yang bisa menciptakan efisiensi,  pemasaran produk untuk memperluas jangkauan pemasaran, serta administrasi pembukuan usaha. Kegiatan ini diharapkan bisa meningkatkan daya saing UMKM Tahu Barokah ditengah ketatnya persaingan produk serupa. Kegiatan yang dilakukan selama kurang lebih dua bulan ini, mendapat respon yang baik dari pelaku usaha dan masyarakat sekitar.
Penyuluhan Dan Pelatihan Invisible & Visible Knowledge Profiling Untuk Meningkatkan Kompetensi Pada SMA Negeri 3 Semarang
Authors: Gamayanto Indra , Sukamto Titien Suhartini , Sani Ramadhan Rakhmat , Wibowo Sasono , Winarno Sri , Rohmani Asih
Published: September 2021

AbstrakPendidikan memiliki arti menggabungkan antara pengetahuan dan pengalaman untuk menghasilkan inovasi yang bermanfaat bagi umat manusia. Keduanya saling terhubung satu sama lain dan tidak boleh dipisahkan. Oleh sebab itu, menggabungkan antara pengetahuan dan pengalaman adalah hal mutlak yang seharusnya diterapkan dalam semua lini pendidikan agar siap dalam menghadapi globalisasi dengan level tertinggi. Definisi kesempurnaan adalah menggabungkan antara pengetahuan dan pengalaman sehingga menghasilkan hal-hal inovatif yang bermanfaat dan memberikan kontribusi positif terhadap hidup orang banyak. Artikel ini merupakan penyuluhan dan pelatihan invisible & visible knowledge profiling yang merupakan dua hal penting yang harus dapat dikembangkan di dalam pendidikan dan dunia kerja. Lebih jauh lagi, artikel ini merupakan pengembangan dari artikel sebelumnya yaitu pelatihan dan implementasi social media profiling. Pengabdian masyarakat yang kami lakukan haruslah berkelanjutan dan terus dikembangkan hingga mencapai tingkat kualitas tertinggi dalam pengetahuan, inilah prinsip yang terdapat pada invisible & visible knowledge profiling. Hasil dari artikel ini adalah bagaimana car akita meningkatkan kinerja sumber daya manusia yang terdapat di dalam dunia pendidikan, profil lengkap kemampuan dan sumber daya manusia yang ada, klasifikasi dan tahapan apa saja yang seharusnya dapat dilakukan. Konsep dalam artikel ini menggabungkan dengan tiga metode yaitu  3SDP-mendukung komunitas belajar aktif, merancang peluang kepemimpinan, menghasilkan sumber daya pendidikan (yang berasal dari Harvard University), Johari window dan E=KM.C2. Kata kunci: Pendidikan, Invisible-visible knowledge, Inovasi, Profiling, Sumber Daya Manusia
Community Diagnosis dan Peningkatan Pengetahuan Penyakit Hipertensi pada Masyarakat RT. 02 Desa Dalam, Kecamatan Alas, Sumbawa
Authors: Utami Dian Oktamulada , Sulistyawati Sulistyawati
Published: September 2021

Community diagnosis is a technique to capture the main health problems. Hypertension is a common problem in Indonesian society and is even ignored because the disease development process is not visible. This community service aims to carry out a community diagnosis to see priority problems in the location for further intervention to the community. It was found that hypertension was the main problem. Increasing knowledge of the society about hypertension is conducted by installing posters in the public space.
Strategi Partisipatif Pembangunan Sosial di Pulau Penyengat Kota Tanjungpinang
Authors: Mahadiansar Mahadiansar , Romadhan Fedro
Published: September 2021

Pembangunan sosial merupakan bagian strategi dalam penggerakan partisipasi masyarakat agar pada sektor pembangunan yang berkelanjutan bisa memiliki peran dengan menghadirkan masyarakat yang partisipatif. Tulisan ini menjelaskan kondisi kekinian yang terjadi dipulau penyengat sebagai wilayah yang strategis dalam menjaga kehidupan sosial menjadi lebih baik. Jenis pengabdian masyarakat menggunakan metode pendekatan dialog face to face, observation, dan win-win solution yang kemudian penulis interpretasikan dengan kata-kata yang diuraikan secara deskriptif. Hasil pengabdian menghasilkan sebuah solusi pada penguatan partisipasi masyarakat dalam pembangunan sosial. Selain itu untuk mendukung strategi inovasi pembangunan sosial, perlunya peningkatan kualitas sumber daya manusia atau masyarakat bisa berperan aktif dari lima sektor (infrastruktur, kesehatan, budaya, sosial dan lingkungan) yang menjadi fokus utama dalam mendorong inovasi pembangunan sosial berbasis masyarakat. Diharapkan dengan adanya strategi inovasi pembangunan sosial tersebut dapat meningkatkan kemandirian masyarakat pulau penyengat dalam melakukan upaya peningkatan kesejahteraan masyarakat mendapatkan dampak positif yang telah diimplementasikan sebagai rujukan inovasi pembangunan sosial di Kota Tanjungpinang.
Pendidikan ketika Pandemi Covid-19 di Desa Rejosari, Grobogan, Jawa Tengah
Authors: Sujatmiko Riky Fajar , Anggraini Wike
Published: September 2021

Kebijakan pembelajaran daring merupakan salah satu cara pemerintah Indonesia untuk tetap memberikan jaminan pendidikan dengan mengurangi resiko penyebaran Covid-19. Namun para guru, murid-murid, dan orang tua kesulitan dalam melaksanakan kebijakan tersebut. Tujuan kegiatan pengabdian masyarakat ini untuk meningkatkan kesadaran masyarakat akan pentingnya pendidikan demi kemajuan Bangsa Indonesia meskipun dalam keterbatasan disaat pandemi Covid-19 agar semangat dalam belajar tetap terjaga. Kegiatan pengabdian masyarakat ini dilaksanakan dengan metode sosialisasi yang ditunjukkan untuk tiga kelompok, yaitu kelompok anak-anak, kelompok remaja, dan kelompok orang tua. Pada pelaksanaan sosialisasi untuk kelompok anak-anak, mereka merasa lebih nyaman belajar dengan tatap muka. Kemudian penulis membuat sebuah lomba cerdas cermat melalui platform quizizz.com agar mereka termotivasi untuk menggunakan smartphone dalam proses pembelajaran. Kemudian pada kelompok remaja, penulis menyampaikan sosialisasi pada kegiatan Pusat Informasi dan Konseling Remaja di Dusun Plosonambangan. Sosialisasi pada kelompok dewasa, dilaksanakan di Balai Desa Rejosari dengan peserta ibu-ibu. Kegiatan sosialisasi berjalan dengan lancar dan sukses yang ditandai dengan ketertarikan peserta ketika mendengar penyampaian sosialisasi, antusiasme dalam bertanya serta hasil dari survei melalui Google Form.
Pelatihan Inklusif Advokasi Kebijakan Hak-Hak Penyandang Disabilitas di Komunitas SOBAT Difabel
Authors: Rizky Ulfah Fatmala
Published: September 2021

Pengabdian kepada masyarakat ini bertujuan untuk melatih keterampilan dan kapabilitas penyandang disabilitas dan non-penyandang disabilitas supaya dapat memperjuangkan perlindungan dan pemenuhan hak-hak penyandang disabilitas melalui proses advokasi kebijakan. Pengabdian masyarakat ini dilaksanakan secara daring dengan menggunakan aplikasi konferensi video Google Meet dan aplikasi presentasi Mentimeter. Metode yang digunakan dalam pengabdidan kepada masyarakat ini, yaitu: pertama, metode seminar untuk menjelaskan materi. Kedua, metode latihan soal dan diskusi untuk memperdalam dan mengonfirmasi pemahaman peserta. Ketiga, metode kuantitatif deskriptif dengan menggunakan instrumen kuesioner untuk mengevaluasi pelaksanaan dan luaran dari kegiatan pengabdian kepada masyarakat ini.
The Challenge of Home Allergen Re-introductions Using the Ladder Approach in Children With Non-IgE Mediated Gastrointestinal Food Allergy
Authors: Meyer Rosan , De Koker Claire , Dziubak Robert , Godwin Heather , Reeve Kate , Chebar-Lozinsky Adriana , Foong Ru-Xin , Skrapac Ana-Kristina , Ellmer Marlene , Shah Neil
Published: September 2021

Background: Oral food challenges remain the most reliable method for allergy confirmation. Although consensus guidelines have been published to unify Immunoglobulin E (IgE)-mediated challenges, this does not exist for non-IgE mediated gastrointestinal allergies outside of Food Protein Induced Enterocolitis Syndrome. We therefore set out to establish the use of home introduction protocols (HIP) for confirmation of food allergy for milk, soya, egg and wheat using a ladder approach in children with non-IgE mediated allergy.

Materials and Methods: Patients with suspected non-IgE mediated gastrointestinal allergies (0–16 years) were recruited following symptom improvement on an elimination diet. All children had skin prick or specific IgE tests to rule out IgE-mediated allergies prior to suggestion the HIP. Number of trials and outcome was documented. HIPs were developed using a published ladder approach for cow's milk as baseline and final dose was calculated based on guidelines for food protein induced enterocolitis syndrome and portions for age from the National Diet and Nutrition Survey. First foods were baked/highly processed and every 4th day patients moved to a more unprocessed/unheated food.

Results: From 131 recruited patients, 117 (89.3%) followed the HIP for food allergens. No adverse events were documented. In more than 50% of cases one attempt at the HIP was sufficient to establish allergy status, but many required 2–5 attempts before the outcome was clear. About half of the children were fully tolerant to foods they initially eliminated: 36, 26 and 30% were partially tolerant to milk, soya, and egg and only 15% achieved partial tolerance to wheat. Wheat was the allergen introduced earliest, followed by soya, cow's milk and egg.

Conclusions: This study indicates that home HIPs are safe in non-IgE mediated gastrointestinal food allergy and that the ladder approach may be useful in re-introducing allergens in children at home with non-IgE mediated gastrointestinal allergies. From this study we can also conclude that tolerance to processed/baked allergens was observed in many children. Further studies should be performed on the HIP and ideally reintroduction should occur pre-defined time intervals.
Exosomal Proteins and miRNAs as Mediators of Amyotrophic Lateral Sclerosis
Authors: Chen Qiao Yi , Wen Ting , Wu Peng , Jia Rui , Zhang Ronghua , Dang Jingxia
Published: September 2021

Recent advances in the neurobiology and neurogenerative diseases have attracted growing interest in exosomes and their ability to carry and propagate active biomolecules as a means to reprogram recipient cells. Alterations in exosomal protein content and nucleic acid profiles found in human biological fluids have been correlated with various diseases including amyotrophic lateral sclerosis (ALS). In ALS pathogenesis, these lipid-bound nanoscale vesicles have emerged as valuable candidates for diagnostic biomarkers. Moreover, their capacity to spread misfolded proteins and functional non-coding RNAs to interconnected neuronal cells make them putative mediators for the progressive motor degeneration found remarkably apparent in ALS. This review outlines current knowledge concerning the biogenesis, heterogeneity, and function of exosomes in the brain as well as a comprehensive probe of currently available literature on ALS-related exosomal proteins and microRNAs. Lastly, with the rapid development of employing nanoparticles for drug delivery, we explore the therapeutic potentials of exosomes as well as underlying limitations in current isolation and detection methodologies.
Magnetic Properties of Electrodeposited Cobalt-Platinum (CoPt) and Cobalt-Platinum-Phosphide (CoPtP) Thin Films
Authors: Park D.-Y. , Myung N. V.
Published: September 2021

CoPt and CoPtP thin films were synthesized using direct current (DC) aqueous electrodeposition from weak alkaline solutions. The basic plating solutions of binary CoPt thin films consisted of cobalt pyrophosphate [Co2P2O7] and chloroplatinic acid [H2PtCl6]. Various amounts of sodium hypophosphite [NaH2PO2] was added to deposit ternary CoPtP thin films. The film composition was adjusted by varying the several electrodeposition parameters including electrolyte composition, solution pH, and current density and correlated to their microstructure and magnetic property (i.e. coercivity and squareness). For the binary CoPt thin films, the maximum coercivities [in-plane coercivity (Hc,//) = ∼1,600 Oe, and perpendicular coercivity (Hc,⊥) = ∼2,500 Oe] were obtained from electrolytes containing 0.01 M H2PtCl6 + 0.04 M Co2P2O7 at current density (CD) of 7.5 mA cm−2. In the case of ternary CoPtP electrodeposits, the maximum coercivities (Hc,// = ∼2,600 Oe, and Hc,⊥ = ∼3,800 Oe) were achieved from baths containing 0.015 M H2PtCl6, 0.07 M Co2P2O7, 0.8 M NaH2PO2 at CD of 7.5 mA cm−2 and solution pH 9. It was suggested that microstructure and magnetic properties are affected not only by the type of substrate but also by chemical compositions and electrodeposition conditions.
Health Inequity by Design: Waiting Rooms and Patient Stress
Authors: Lamb Matthew D.
Published: September 2021

Little attention has been paid to health inequities designed into the physical spaces themselves. Clearly design is an important part of patient care. Design is simultaneously a complex system itself while existing as part of a larger complex (healthcare) system. For example, it is not enough to say that a patient experiences more stress because she/he is being treated in a hospital in a lower income area. The key, here, is that evidence demonstrates design as an important component, systemically, in healthcare. We know this to be true and base re-design efforts on this fact, but only in certain places. The central addition of this study is to point out that hospitals in higher income areas utilize the waiting room’s ecology and its influence on patient stress and care. Efforts to intervene, through design, in waiting room ecology have consequences to equitable access to healthcare. Therefore, this study examines the implications of health inequities designed-into physical space. Additionally, this study seeks to forefront the influence communication ecologies have in addressing health inequities. Innovations in addressing mental health needs in humanitarian settings: A complexity informed Action Research Case Study. Frontiers in Communication: Health Communication. 10.3389/fcomm.2020.601792 para 19, 2020). Thus, the purpose of this paper is to investigate, but also articulate, the ways design decisions impact people unequally and perpetuate health inequalities. To do so, this study investigates the communication ecologies of waiting rooms and their influence on patient stress and health equity and elucidates under-examined systemic components patient stress and well-being.
Usefulness of Diastolic Function Score as a Predictor of Long-Term Prognosis in Patients With Acute Myocardial Infarction
Authors: Bae SungA , Yoon Hyun Ju , Kim Kye Hun , Kim Hyung Yoon , Park Hyukjin , Cho Jae Yeong , Kim Min Chul , Kim Yongcheol , Ahn Youngkeun , Cho Jeong Gwan , Jeong Myung Ho
Published: September 2021

Background: Left ventricular diastolic function (LVDF) evaluation using a combination of several echocardiographic parameters is an important predictor of adverse events in patients with acute myocardial infarction (AMI). To date, the clinical impact of each individual LVDF marker is well-known, but the clinical significance of the sum of the abnormal diastolic function markers and the long-term clinical outcome are not well-known. This study aimed to investigate the usefulness of LVDF score in predicting clinical outcomes of patients with AMI.

Methods: LVDF scores were measured in a 2,030 patients with AMI who underwent successful percutaneous coronary intervention from 2012 to 2015. Four LVDF parameters (septal e′ ≥ 7 cm/s, septal E/e′ ≤ 15, TR velocity ≤ 2.8 m/s, and LAVI ≤ 34 ml/m2) were used for LVDF scoring. The presence of each abnormal LVDF parameter was scored as 1, and the total LVDF score ranged from 0 to 4. Mortality and hospitalization due to heart failure (HHF) in relation to LVDF score were evaluated. To compare the predictive ability of LVDF scores and left ventricular ejection fraction (LVEF) for mortality and HHF, receiver operating characteristic (ROC) curve and landmark analyses were performed.

Results: Over the 3-year clinical follow-up, all-cause mortality occurred in 278 patients (13.7%), while 91 patients (4.5%) developed HHF. All-cause mortality and HHF significantly increased as LVDF scores increased (all-cause mortality–LVDF score 0: 2.3%, score 1: 8.8%, score 2: 16.7%, score 3: 31.8%, and score 4: 44.5%, p < 0.001; HHF–LVDF score 0: 0.6%, score 1: 1.8%, score 2: 6.3%, score 3: 10.3%, and score 4: 18.2%, p < 0.001). In multivariate analysis, a higher LVDF score was associated with significantly higher adjusted hazard ratios for all-cause mortality and HHF. In landmark analysis, LVDF score was a better predictor of long-term mortality than LVEF (area under the ROC curve: 0.739 vs. 0.640, p < 0.001).

Conclusion: The present study demonstrated that LVDF score was a significant predictor of mortality and HHF in patients with AMI. LVDF scores are useful for risk stratification of patients with AMI; therefore, careful monitoring and management should be performed for patients with AMI with higher LVDF scores.
Redox-Controlled Ammonium Storage and Overturn in Ediacaran Oceans
Authors: Hallmann Christian , Grosjean Emmanuelle , Shapiro Nathan D. , Kashiyama Yuichiro , Chikaraishi Yoshito , Fike David A. , Ohkouchi Naohiko , Summons Roger E.
Published: September 2021

As a key nutrient, nitrogen can limit primary productivity and carbon cycle dynamics, but also evolutionary progress. Given strong redox-dependency of its molecular speciation, environmental conditions can control nitrogen localization and bioavailability. This particularly applies to periods in Earth history with strong and frequent redox fluctuations, such as the Neoproterozoic. We here report on chlorophyll-derived porphyrins and maleimides in Ediacaran sediments from Oman. Exceptionally light δ15N values (< –10‰) in maleimides derived from anoxygenic phototrophs point towards ammonium assimilation at the chemocline, whereas the isotopic offset between kerogens and chlorophyll-derivatives indicates a variable regime of cyanobacterial and eukaryotic primary production in surface waters. Biomarker and maleimide mass balance considerations imply shallow euxinia during the terminal Ediacaran and a stronger contribution of anoxygenic phototrophs to primary productivity, possibly as a consequence of nutrient ‘lockup’ in a large anoxic ammonium reservoir. Synchronous δ13C and δ15N anomalies at the Ediacaran–Cambrian boundary may reflect one in a series of overturn events, mixing ammonium and isotopically-light DIC into oxic surface waters. By modulating access to nitrogen, environmental redox conditions may have periodically affected Ediacaran primary productivity, carbon cycle perturbations, and possibly played a role in the timing of the metazoan radiation across the terminal Ediacaran and early Cambrian.
A Perspective on the Educational Psychological Value of Jurassic Park and Similar Films for Bioethics Discussions
Authors: Attwood Adam I.
Published: September 2021

This paper, with recommendations for teachers and teacher educators, discusses the Jurassic Park science-fiction series with a parallel mention of the Night at the Museum trilogy addressing the educational value of this subgenre of film for bioethics discussion in social studies classes. These film series were selected for analysis because of their long-standing popularity, especially Jurassic Park that has continued as a series for over three decades. As such, this paper posits that representations of anthropology, archaeozoology, and related fields in popular entertainments films can be motivational for students to explore these careers for themselves or at least develop and interest in studying bioethics as an important discussion in social studies and science.
Pornography Use Could Lead to Addiction and Was Associated With Reproductive Hormone Levels and Semen Quality: A Report From the MARHCS Study in China
Authors: Cui Zhihong , Mo Min , Chen Qing , Wang Xiaogang , Yang Huan , Zhou Niya , Sun Lei , Liu Jinyi , Ao Lin , Cao Jia
Published: September 2021

This study aimed to investigate the situations of pornography use among male college students of China, to explore the addiction possibility for pornography use, and to study the associations between pornography use and reproductive hormone levels and semen quality. Five hundred sixty-eight participants met the inclusion criteria and finished all of the questionnaires and hormone level and semen parameter examinations. A majority of participants (except one) had pornography use experience, 94.2% participants started pornography use before college, and 95.9% participants reported they had masturbation experience when using pornography. Early contact to pornography, frequent pornography use, high amount of time spending on pornography use, and frequent masturbation during pornography use were correlated with addiction trends. Earlier pornography use was found to be associated with lower serum prolactin (PRL), follicle-stimulating hormone (FSH), and progesterone (Prog), as well as lower sperm concentration and total sperm count. Higher frequency of pornography use was associated with lower serum estrogen (E2). In conclusion, pornography use was common among male college students in China. Early contact, high frequent use, and high frequency of masturbation during pornography use could lead to addiction trends and aberrant reproductive hormone levels and semen quality.
Characteristics Analysis of Small Insulated Vans Based on Thermoelectric Cooling
Authors: Yuan Xiao-Hong , Qin Chuang-Hui , Wang Yi-Ping , Liu Xun
Published: September 2021

In cold chain logistics, refrigerated trucks are used for long-distance transportation across cities, and insulated trucks are used for short-distance delivery within cities. However, the small insulated vans for short-distance transportation like delivering home in urban have heat leakage and no pre-cooling, the transportation time of traffic congestion becomes longer, resulting in poor insulation effect. So, to achieve stable temperature control is difficult, it leads to a big fluctuation in the temperature of the cargo. The thermoelectric cooling technology has the unique advantages of compact structure, flexible layout, no refrigerant, and environmental friendliness, which is very suitable for controlling the temperature of the small insulated vans. In the paper, relationship among COP, working power, and working current of the designed thermoelectric cooler (TEC) is investigated first. And then the best working state of the TEC is obtained. Next, set hot and cold dual temperature zones to ensure the effective use of energy based on thermoelectric cooling characteristics, arranged the cooling device in the insulated van, and revealed the changes in the temperature of the compartment and the cargo through the actual vehicle test. Compared the thermal insulation effect of the compartment with or without thermoelectric cooling technology through CFD. According to the simulation results, the cargo temperature of the insulated van fluctuates between 4 and 6°C within 2.5 h of actual delivery in urban, the insulated van using thermoelectric cooling technology can make the temperature of the cargo fluctuate within 1.5°C. The above proved the good insulated effect of the thermoelectric cooling insulated vans. Finally, the influence of the working time of the thermoelectric refrigeration system on the temperature control effect is also studied. The research results have a certain guiding significance for the application of thermoelectric cooling technology in insulated vans.
Changes of a Landfill Leachate Toxicity as a Result of Treatment With Phragmites australis and Ceratophyllum demersum–A Case Study
Authors: Szymańska-Pulikowska Agata , Wdowczyk Aleksandra
Published: September 2021

Most phytoremediation studies are limited to several of the most common plants and in most cases these studies are performed to a very limited extent. There are also few publications on the assessment of the effectiveness of the removal of pollutants, performed simultaneously with various plants and using physicochemical analyses as well as toxicity tests. Therefore, the conducted studies focused on assessing the removal of pollutants from leachate by physicochemical analyses and toxicity tests. The leachate was collected from four municipal waste landfills of different ages (2 non-operational facilities and 2 active). The studies were conducted for two biological systems: using emergent macrophytes (Phragmites australis) and submergent macrophytes (Ceratophyllum demersum L.). It has been observed that efficiency of biological treatment of leachates with Phragmites australis and Ceratophyllum demersum shows significant differences at lower concentrations of solutions. Even after the treatment with Phragmites australis and Ceratophyllum demersum, the analyzed leachate samples produced a toxic effect on the test organisms. A reduction or no toxicity of the leachate after the biological treatment was observed only in some cases. The observed effects of the biological leachate treatment were not conclusive. Particular attention should be paid to the persistent toxicity, which can pose a real threat to the environment when discharging leachates after treatment.
Identification of a miRNA–mRNA Regulatory Networks in Placental Tissue Associated With Tibetan High Altitude Adaptation
Authors: Tenzing Noryung , van Patot Martha Tissot , Liu Huifang , Xu Qiying , Liu Juanli , Wang Zhuoya , Wang Yanjun , Wuren Tana , Ge Ri-Li
Published: September 2021

The Tibetan population has lived and successfully reproduced at high altitude for many generations. Studies have shown that Tibetans have various mechanisms for protection against high-altitude hypoxia, which are probably due, at least in part, to placental adaptation. However, comprehensive in silico analyses of placentas in Tibetans are lacking. We performed a microarray-based comparative transcriptome analysis of 10 Tibetan women from Yushu, Qinghai, CHN (∼3,780 m) and 10 European women living in Leadville, CO, United States (∼3,100 m) for less than three generations. Expression of HIF-1α, STAT3, EGFR, HSP5A, XBP1, and ATF6A mRNA was less in the Tibetan placentas as compared with European placentas. A total of 38 miRNAs were involved in regulating these genes. Differentially expressed genes were enriched for HIF1α signaling pathways, protein processing in the endoplasmic reticulum, PI3K-AKT signaling pathways, and MAPK signaling pathways. Based on the transcriptome profiles, the Tibetan population was distinct from the European population; placental tissues from the Tibetan population are lacking hypoxic responses, and “passivation” occurs in response to hypoxic stress. These results provide insights into the molecular signature of adaptation to high altitudes in these two populations.
Gibberellin Induced Transcriptome Profiles Reveal Gene Regulation of Loquat Flowering
Authors: Jiang Yuanyuan , Liu Yicun , Gao Yongshun , Peng Jiangrong , Su Wenbing , Yuan Yuan , Yang Xianghui , Zhao Chongbin , Wang Man , Lin Shunquan , Peng Ze , Xie Fangfang
Published: September 2021

Flowering is an integral part of the life cycle of flowering plants, which is essential for plant survival and crop production. Most woody fruit trees such as apples and pears bloom in spring, but loquat blooms in autumn and winter. Gibberellin (GA) plays a key role in the regulation of plant flower formation. In this study, we sprayed loquat plants with exogenous GA3, which resulted in vigorous vegetative growth rather than floral bud formation. We then performed a comprehensive RNA-seq analysis on GA3-treated and control-treated leaves and buds over three time periods to observe the effects of exogenous GA3 application on floral initiation and development. The results showed that 111 differentially expressed genes (DEGs) and 563 DEGs were down-regulated, and 151 DEGs and 506 DEGs were up-regulated in buds and leaves, respectively, upon treatment with GA3. Among those that are homologs of the DELLA-mediated GA signal pathway genes, some may be involved in the positive regulation of flower development, including EjWRKY75, EjFT, EjSOC1, EjAGL24, EjSPL, EjLFY, EjFUL, and EjAP1; while some may be involved in the negative regulation of flower development, including EjDELLA, EjMYC3, EjWRKY12, and EjWRKY13. Finally, by analyzing the co-expression of DEGs and key floral genes EjSOC1s, EjLFYs, EjFULs, EjAP1s, 330 candidate genes that may be involved in the regulation of loquat flowering were screened. These genes belong to 74 gene families, including Cyclin_C, Histone, Kinesin, Lipase_GDSL, MYB, P450, Pkinase, Tubulin, and ZF-HD_dimer gene families. These findings provide new insights into the regulation mechanism of loquat flowering.
Myo-Inositol Restores Tilapia’s Ability Against Infection by Aeromonas sobria in Higher Water Temperature
Authors: Yang Man-jun , Jiang Ming , Peng Xuan-xian , Li Hui
Published: September 2021

Bacterial infection presents severe challenge to tilapia farming, which is largely influenced by water temperature. However, how water temperature determines tilapias’ survival to infection is not well understood. Here, we address this issue from the perspective of metabolic state. Tilapias were more susceptible to Aeromonas sobria infection at 33°C than at 18°C, which is associated with differential metabolism of the fish. Compared to the metabolome of tilapia at 18°C, the metabolome at 33°C was characterized with increased an tricarboxylic acid cycle and a reduced level of myo-inositol which represent the most impactful pathway and crucial biomarker, respectively. These alterations were accompanied with the elevated transcriptional level of 10 innate immune genes with infection time, where il-1b, il-6, il-8, and il-10 exhibited a higher expression at 33°C than at 18°C and was attenuated by exogenous myo-inositol in both groups. Interestingly, exogenous myo-inositol inactivated the elevated TCA cycle via inhibiting the enzymatic activity of succinate dehydrogenase and malate dehydrogenase. Thus, tilapias showed a higher survival ability at 33°C. Our study reveals a previously unknown relationship among water temperature, metabolic state, and innate immunity and establishes a novel approach to eliminate bacterial pathogens in tilapia at higher water temperature.