bluuebunny/crossref_metadata_2025 huggingface dataset:
Logistics and supply chain for mice cities
Authors:   , Sriraksa Chanmatha
Published: April 2023

The aim of this study was threefold; 1) to examine success factors of logistics and supply chain for MICE cities, 2) to investigate influences of socio-demographic factors on stakeholders perception of logistics and supply chain for MICE cities, and 3) to identify significant competitive advantage determinants of logistics and supply chain for a city to be selected as MICE city. Based on some common characteristics and differences by nature of location, Phitsanulok, Khon Kaen and Krabi were purposively selected. Research tool is a set of questionnaire consisting of four main parts that were demographic information, logistics and supply chain success factors for MICE cities, pairwise comparison of MICE cities, and suggestion. Participants were 429 respondents from two main industries; transportation industry and the Meetings industry, as well as related stakeholders. Data analysis employed descriptive statistics for socio-demographic description. Analysis of Variance (ANOVA) and independent sample t-test were used to examine impacts of socio-demographic factors. Through Analytical Hierarchy Process (AHP) and Multinomial Logistic Regression (MLR), significant attributes affecting probability of one city to be selected as MICE city were identified. Findings revealed that seven factors influencing MICE city competitiveness were international routes, airport-city connectivity, MICE experience, accommodation, innovation city, exhibition city, and leisure city. However, the results show that each factor considerably provided different effects on each city. This study shed light on how the government and stakeholders can construct a strategic guideline to develop logistics and supply chain to their full potential and the city future growth as MICE city
Graph grabbing games and toucher-isolator games
Authors:   , Boriboon Sopon
Published: April 2023

In this research, we study the graph grabbing game and the Toucher-Isolator
game. In the graph grabbing game, we partially confirm a conjecture of Seacrest
and Seacrest which states that Alice wins the game on every weighted connected
bipartite even graph. In the Toucher-Isolator game, we give a simple alternative
proof of a result of Räty that determines the most suitable tree on n vertices for
Toucher which answers a question of Dowden, Kang, Mikalački and Stojaković.
Knight's tours on ringboards, deficient 4 x n chessboards and some l-boards
Authors:   , Srichote Wasupol
Published: April 2023

A (legal) knight's move is the result of moving the knight two squares horizontally or vertically on the board and then turning and moving one square in a perpendicular direction. A closed knight's tour is a sequence of knight's moves that visits every square on a given chessboard exactly once and returns to its start square. A closed knight's tour and its variations are studied widely over the rectangular chessboard or a three-dimensional rectangular box. For m,n > 2r, an (m,n,r)-ringboard or RB(m,n,r) is defined to be an m x n chessboard, denoted by CB(m x n), with the middle part missing and the rim contains r rows and r columns. Next, if A is a set of two squares of CB(4 x n), then CB(4 x n) - A is the deficient board after deleting these two squares. In this dissertation, we study the existence of closed knight's tours on RB(m,n,r) and CB(4 x n) - A.
Application of phage display technology for the production of antibodies againstStreptococcus suis serotype 2
Authors:   , Sulong Pattarawadee
Published: April 2023

Streptococcus suis (S. suis) serotype 2 infection is problematic in the swine industry and responsible for most cases of human infection worldwide. Since current multiplex PCR cannot differentiate between serotypes 2 and 1/2, then serotype-specific antibodies (Abs) are required for serotype identification to confirm S. suis serotype 2 infection. This study aimed to generate Abs specific to S. suis serotype 2 by phage display from a human heavy chain variable domain (VH) antibody library. For biopanning, whole cells of S. suis serotype 2 were used as the target antigen. With increasing selection stringency, we could select the VH Abs that is specifically bound to S. suis serotype 2 surface antigen, which was identified as the capsular polysaccharide (CPS). From ELISA analysis, the specific phage clone 47B3 VH with the highest binding activity to S. suis serotype 2 was selected and shown to have no cross-reactivity with S. suis serotypes 1/2, 1, and 14 that share a common epitope with serotype 2 and occasionally cause infections in human. Moreover, 47B3 VH shown no cross-reactivity with other septic bacteria colonizing blood specimens. Then, 47B3 VH was successfully expressed as soluble 47B3 VH in SHuffle® T7 E. coli. The soluble 47B3 VH was tested for the binding ability in a dose-dependent ELISA assay. The results indicated that the activity of phage clone 47B3 was still retained even in the soluble form. The specificity test of the soluble 47B3 VH was further determined. The results showed that the soluble 47B3 VH was also specifically bound with serotype 2 human clinical isolate and had no cross-reactivity with other virulent S. suis serotypes in human cases. The quellung reaction demonstrated that the soluble 47B3 VH could differentiate between S. suis serotypes 2 and 1/2 in terms of bioactivity. Thus, this VH Ab is beneficial in the diagnosis of disease or the discrimination of S. suis serotypes. Furthermore, the results of this study here could warrant the phage display VH platform to produce serotyping Abs.
Neutrophil Extracellular Traps (NETs) formation of Fcgr2b deficient mice in lupus mouse model with ischemic reperfusion injury
Authors:   , Saisorn Wilasinee
Published: April 2023

Acute kidney injury (AKI) caused by renal ischemic reperfusion (I/R) is the most prevalent cause of morbidity and mortality in patients. Neutrophil extracellular traps (NETs) are important for the progression of lupus nephritis after renal I/R injury. Because neutrophils are the first immune cell that respond to tissue damage, neutrophils might be an important cell that determines renal I/R injury. Additionally, NET components, including cell-free DNA, histone, nucleosome, and cytoplasmic protein compartment release the auto-antigens that accelerate lupus disease activity. Therefore, this project aimed to compare NETs formation in several internal organs following renal I/R injury in Fcgr2b deficient (Fcgr2b-/-) mice, a lupus mouse model, and wildtype (WT) mice. At 24 h after I/R injury, Fcgr2b-/- mice had a higher level of NET biomarkers; PAD4, IL-1β expression, serum dsDNA, and the co-staining of neutrophil elastase (NE) with myeloperoxidase (MPO), in kidney and peripheral blood when compared with WT mice. Furthermore, the cell apoptosis activated caspase-3 in the kidney, serum anti-dsDNA, and immunoglobulin (IgG) deposition in glomeruli in Fcgr2b-/- mice at 120 h after I/R injury was also higher than the WT mice. Likewise, NETs formation and apoptosis Fcgr2b-/- neutrophils after stimulation with phorbol myristate acetate (PMA) or lipopolysaccharide (LPS) were more prominent than WT neutrophils. These findings support that Fcgr2b-/- mice with renal I/R had a higher NETs formation, cell apoptosis in the kidney and in the remote organs that induced serum anti-dsDNA and accelerated lupus disease aggression.
Prevalence of eating problems and related factors in professional female models above 18 years old in Bangkok
Authors:   , Elstow Worada
Published: April 2023

The purpose of this cross-sectional descriptive study was to study the prevalence of eating problems in professional models and to study the related factors that contribute to eating problems in professional models above 18 years old in bangkok. The data was collected in 109 female models in Bangkok. Self-report questionnaires include general background questionnaire created by the researcher to ascertain personal and occupational information along with the use of the Thai Eating Attitude Test 40 (EAT-40), The Thai Body Image Dissatisfaction Scale, and The Thai Hospital Anxiety and Depression Scale (HADS). Statistical analysis of Chi-square and Fisher’s Exact tests were performed to examine associated factors which had significant relations to the models’ eating problems.

The results revealed that Fifteen point six percent of models have a problematic eating attitude with statistically significant relating factors being depression, anxiety, body dissatisfaction, Body Mass Index (BMI), diet frequency, and self-comparison to model colleagues.
A causal model of functional status among persons with liver cirrhosis
Authors:   , Maninet Surachai
Published: April 2023

This cross-sectional correlation study aimed to develop and test a causal relationship among alcohol consumption, illness perception, social support, fatigue, and functional status among persons with liver cirrhosis. The hypothesized model was constructed based on the theory of unpleasant symptoms and the review of the literature. A stratified three-stage random sampling approach was utilized to recruit 400 persons with liver cirrhosis aged 40 years old and older who visited four hospitals from three regions of Thailand. Research instruments consisted of the demographic data form, Alcohol Use Disorders Identification Test Consumption, Brief Illness Perception Questionnaire, Multidimensional Scale of Perceived Social Support, Fatigue Severity Scale, and the Functional Status Questionnaire. Data were collected from May to August 2020. The developed model was verified via a structural equation modeling using SPSS and Mplus program.

 The study findings revealed that the hypothesized model fit the empirical data and explained 71.3% of the variance of functional status χ2 = 386.458, df = 172, (p =.061), χ2/df = 2.397, RMSEA = .056, CFI = .985, TLI = .981, SRMR = .048. Social support was the most the influential factor affecting functional status by having both positive direct and indirect effects on functional status through illness perception and alcohol consumption (β = .744, p<.001). In addition, illness perception had a negative both direct and indirect effects on functional status through fatigue (β = -.291, p<.001). Alcohol consumption had a negative direct and indirect effects on functional status through fatigue (β = -.231, p<.001). Fatigue had only a negative direct effect on functional status (β = -.218, p<.001).

The findings indicated that social support, alcohol consumption, illness perception, and fatigue were important factors influencing functional status among persons with liver cirrhosis. Therefore, further nursing intervention should consider on enhancing social support, reducing alcohol consumption, promoting positive illness perception, and managing fatigue into account to maintain or enhance functional status among persons with liver cirrhosis.
GENERALIDADES SOBRE FRACTURAS
Authors: Alvaro Alex , Bermeo Karina , Sanmartín Carmen , Cortés Mayra , De La Cadena Margarita , Echeverria Daniel , Freire Byron , Guamán Clara , Reyes Byron , Samueza Diana
Published: April 2023

Este material va dirigido sobre todo a los médicos jóvenes o estudiantes en etapa de formación con el afán de recordar y adquirir conocimientos básicos sobre Generalidades sobre fracturas que serán aplicados durante su vida en residencia. Teniendo en cuenta la gran importancia que significa manejar este tema, por la alta incidencia según la epidemiologia reportada en nuestro país y de forma mundial. Este texto y la información contenido en el mismo no pretenden reemplazar el consejo de un profesional sobretodo en una situación de emergencia. Recomendando al lector o profesional que curse estudios de especialización profundizar o complementar cada tema con literatura médica más específica para cada tema tomando en cuenta la gran cantidad de texto científico que se genera día a día en el campo de la Medicina.
Sorption of Eosine Y dye onto pre-treated hen feathers in aqueous solution
Authors: Pawar Madhavi
Published: April 2023

The present study reports Eosine Yellow (EosineY) dye removal by adsorption method. For this purpose hen feathers (HF) are used as sorbent. After optimization of various parameters, it was observed that 75.7% removal of dye (25ppm) occurs at pH 4, contact time 1 h using 1.25 g of adsorbent. Adsorption isotherm studies shows that Langmuir model is best fitted for sorption of the dye on selected sorbent. The kinetics and thermodynamics studies revealed that adsorption process follows pseudo second order kinetics and is exothermic in nature. Use of hen feathers for removal of Eosin Y is found to be efficient and cost effective.
MUSEUM EXHIBITION TEXT: INTERCULTURAL AND TRANSLATION ASPECTS
Authors: Novozhilova A.A.
Published: April 2023

The article is devoted to the study of the texts of the museum exhibition, which play the mediator role between visitors of a museum and its artifacts. The purpose of the study is to consider the text of the museum exhibition as an effective tool for intercultural communication. The review of foreign and domestic works shows that multilingual museum exposition helps to develop a dialogue and understanding between different cultures. The author studied the museum labels of the State Hermitage Museum, their grammatical and stylistic peculiarities, which should be taken into account while translating museum texts from Russian into English. It is determined that the grammatical peculiarities of the museum texts are verbless constructions, incomplete sentences, where linguistic norms are violated. The style of the texts of museum expositions is, as a rule, publicistic, some texts also have features of scientific, spoken and literary styles. While translating, the translator should aim to save the meaning and functional style.
ADVENTURES OF THE SOUL: TRANSMISSION OF THE SYSTEM OF MYSTICAL POETRY IN THE LANGUAGE OF VENIAMIN BLAZHENNY
Authors: Azarova N.M.
Published: April 2023

The poetry of Veniamin Blazhenny (the Blessed) can be seen as a vivid example of the translation of the typological properties of the language of mysticism in late 20th century poetry. The artistic nature of the work of the Blessed during this time did not receive a fundamental analysis. The soul, a key concept of Blazhenny’s poetry, reveals undoubted similarities with the conceptualization of the soul and the idea of metempsychosis in Jewish and Judeo-­Christian mysticism. This study focuses on grammatical elements, and in particular the system of pronouns and negative poetics, the way the subject is constructed and the strategy of anti-discursiveness. The key word and concept of Blazhenny’s poetry is the Soul which reveals an undoubted similarity with the conceptualization of the soul and the idea of metempsychosis in Jewish and Jewish-­Christian mysticism.
Movie Ticket Booking Website
Authors: P Uvansankar. , P Vasantha Kumar. , M Ganesh Kumar , devi Kiruba
Published: April 2023

The project objective is to book cinema tickets in online. The Ticket Reservation System is an Internet based application that can be accessed throughout the Net and can be accessed by anyone who has a net connection. This application will reserve the tickets. This online ticket reservation system provides a website for a cinema hall where any user of internet can access it. User is required to login to the system and needs a credit card or must have any of the online payment mode for booking tickets. Tickets can be collected at the counter and Watching movies with family and friends in theatres is one of the best medium of entertainment after having a hectic schedule. But all this excitement vanishes after standing in hours in long queues to get tickets booked. The website provides complete information regarding currently running movies on all the screens with details of show timings, available seats. Ticket reservations are done using credit card and can be cancelled if needed. Our online tickets reservation system is one of the best opportunities for those who cannot afford enough time to get their tickets reserved standing in long queues. People can book tickets online at any time of day or night. Our reservation system also provides option to cancel the tickets which are reserved. Key Word: Online, Ticket, booking, Snacks, Movie.
Using Landsat satellite imagery for assessment and monitoring of long-term forest cover changes in Dak Nong province, Vietnam
Authors: Thien Bui , Phuong Vu
Published: April 2023

Forests are essential in regulating climate and protecting land resources from natural disasters. In Vietnam's Dak Nong province, forest cover has changed significantly between 1989 and 2021. This study applies remote sensing and geographic information systems (GIS) approaches to detect negative changes in forest cover as well as other land cover types. The maximum likelihood classification tool was used to classify Landsat images for the years 1989, 2001, 2011, and 2021, with post-classification accuracy evaluated through kappa coefficient statistics. The potential to based classification on Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI) to detect changes in forest cover compared with supervised classification was also evaluated. The land use and land cover change detection results show that the forest area decreased from 77.54% of the study area in 1989 to 33.97% in 2021, with a total forest loss of 2,953.48 km 2 and only 117.12 km 2 of newly planted forest during this period. Broadly, forest cover in the area has been severely reduced, often due to indiscriminate logging and expansion of agricultural land on the forest edge.
Geospatial analysis of population ageing in Bosnia and Herzegovina
Authors: Kadušić Alma , Smajić Sabahudin , Kunosić Suad , Smajić Nedima
Published: April 2023

The aim of this research is to analyze the spatial distribution of the population ageing in Bosnia and Herzegovina and identify areas of the country that are particularly vulnerable to negative demographic trends. To achieve the goal of the study, data on the ageing coefficient and ageing index for the period 2013-2020 were used. The geospatial analysis of these indicators was performed using global (Global Moran's I and Getis-Ord General G) and local (Anselin Local Moran's I and Getis-Ord G*) indexes of spatial autocorrelation. The research results confirmed the clustering of both indicators. Ageing coefficient values are clustered in municipalities in western, northwestern, Eastern, and central Bosnia and Herzegovina. Ageing index values are clustered in municipalities in central, western, northwestern, and northeastern Bosnia and Herzegovina. This study provides insight into the research methods of spatial demographic trends and phenomena, and its findings can serve as a basis for future demographic research and development in Bosnia and Herzegovina.
Ectopic pelvic kidney in a child: A case report
Authors: Miolski Jelena , Marjanović Jasminka , Stanojević Sanja , Didić Nevena , Zdravković Vera
Published: April 2023

Ntroduction. An ectopic pelvic kidney is an anatomical anomaly in the position of the kidney. In the stage of metanephros, its movement, rotation, and lifting from the pelvis to the lumbar area are absent. Due to vascular or other abnormalities, the kidney does not reach its usual anatomical position and therefore remains ectopic. The position in which it can be placed is retroperitoneal, abdominal, or thoracic, with numerous variations. Case report: A three-month-old male infant underwent kidney screening during an ultrasound examination of the hips. There had been a positive family history in the mother and maternal aunt of the existence of an ectopic, left pelvic kidney, without complications and accompanying symptoms. The clinical findings of the infant's systems were normal, he was developing in terms of body mass. The analyzes of urine, biochemistry, and urine culture did not show any pathological findings. Ultrasound examination showed that the left renal lobe was completely filled with spleen, without visualization of the left kidney. In the right lumbar box, there was the right kidney, with regular dimensions, clear edges and normal thickness of the parenchyma. Inferior to the right kidney, in the area of the right lumbar region, facing inwards, there was the left kidney with regular ultrasonographic characteristics. Urinary bladder was properly positioned, with normal dimensions and wall thickness. The infant was advised to see a pediatric nephrologist. Conclusion: This is another case of an ectopic kidney recorded during an echosonographic examination of the hips, thus demonstrating the importance of routine ultrasound examinations of the abdomen, in order to increase the possibility of early detection of anomalies of the abdominal organs.
The effect of the early "skin-to-skin" contact method on breastfeeding
Authors: Miolski Jelena , Raus Mišela , Radusinović Milica , Zdravković Vera
Published: April 2023

The task of public health is to encourage the mother to initiate and maintain breastfeeding of her child. The main proponents of early breastfeeding should be pediatricians and gynecologists in maternity hospitals. Early "skin-to-skin" contact means that after birth, in the first ten minutes, the newborn is placed in close contact with the mother. After it is born and cries, it is transferred to the bare chest of the mother, who is comfortably placed in bed with her head elevated. The child is placed in a longitudinal position in relation to her, between and above her breasts. The child's head is turned to the side with mandatory monitoring of breathing, and both are covered with a clean, dry sheet. The basis of the mechanism is hormonal. With this kind of mutual contact, oxytocin is released in the mother, and catecholamine concentrations increase in the newborn. The first two hours after birth, the newborn is awake, active, sensitive to touch, smell and temperature simulations that he receives from the mother, which is why this period is the best for starting breastfeeding. The advantages of this method for the mother are: easier and faster stopping of bleeding after childbirth, earlier expulsion of the placenta, greater calmness and relaxation, as well as greater self-efficacy in breastfeeding. The advantages for the newborn are: reduction of postpartum stress and anxiety, less crying, better control of reaching optimal body temperature, importance in establishing microcolonization of the intestinal flora and more effective breastfeeding with earlier discharge from the hospital to home. The application of this method is simple and economically profitable, and short-term and long-term effects are achieved for both the mother and the child.
Vitamin D in the diet and its effects on the nervous system
Authors: Koprivica Marko , Bjelanović Jelena
Published: April 2023

Vitamin D is a liposoluble organic compound that, in addition to calcium metabolism and its effect on the skeletal system, also has numerous other effects on other organ systems, such as the cardiovascular, endocrine, skeletal and immune, but also on the central nervous system. The primary source of vitamin D is food of animal origin; however, vitamin D is synthesized in the skin upon its exposure to sunlight. In this paper, we will also present the studies corroborating the theory that numerous neurological and psychiatric manifestations are due to deficiency of vitamin D.
Nutritional recommendations during long-term administration of glucocorticoids
Authors: Požar Hajnalka
Published: April 2023

Glucocorticoids are highly effective medications used for the treatment of inflammatory and autoimmune disorders in rheumatology, pulmonology and neurology. However, using these medications for a long period of time, or in excessive doses, carries the risk of unwanted effects. Most typical sideeffects can be successfully prevented or reduced with adequate nutritional strategies. Increased appetite and weight gain can be reduced with regular meals with a selection of fresh, unprocessed foods in accordance with the principles of proper nutrition. Hypertension requires a reduced salt intake by < 3.75 g (1/2 teaspoon), along with the use of other herbs spices. Insulin resistance and elevated blood sugar levels can be reduced, by avoiding foods rich in simple carbohydrates, sugar and by preferring complex carbohydrates (whole grains, starchy foods, fruits, vegetables). Due to the high risk of osteoporosis, it is recommended to consume three servings of dairy products and fish per day in order to obtain an adequate intake of vitamin D. However, patients may find these recommendations unclear or overly strict, and they may require assistance, motivation, and repetition of information for practical application of these advice in everyday life.
Patellofemoral joint: Morphology, dysplasia and influence on the onset of chondromalacia of the patella
Authors: Stamatović Ratko , Dulović Dragan , Vojinović Radiša , Vasić-Vilić Jasenka , Ilić Slađana , Nurković Jasmin , Kostić Dejan
Published: April 2023

The patellofemoral joint, the anterior compartment of the knee, undergoes the earliest degenerative changes throughout life and joint morphology is of great importance in the appearance of pain in the anterior knee and chondromalacia of the patella. Chondromalacia of the patella is a progressive disease with a change in normal morphology and structure, with the formation of minor or major defects in the cartilage itself and represents a significant socioeconomic problem because it occurs in young, physically active people. Quadriceps wasting, patellofemoral crepitus, and effusion are obvious clinical indications. In addition, radiological examinations are also necessary for diagnosis. Magnetic resonance imaging (MRI) is a non-invasive diagnostic method, which promises a unique ability to potentially identify cartilage lesions.
The impact of Covid-19 pandemic on coverage of children with mandatory vaccines in the Republic of Serbia
Authors: Krstić Bojana , Despotović Milena , Krstić Miloš , Milovanović Marija , Zlatanović Milena
Published: April 2023

Objective. Infectious diseases have always been a challenge for medicine and healthcare workers. In addition to the enormous progress of medicine, they still represent a major public health problem. The pandemic caused by Covid-19 shows that. Due to the pandemic itself, the overload of the health care system, the fear of infection, the reallocation of health resources to respond to the pandemic, and other measures to control and suppress the infection, routine immunization services for children have been disrupted around the world. The aim of the work is to examine the impact of Covid-19 on the frequency of immunization of children with mandatory vaccines. Methods. Through retrospective analysis of data from the annual reports of the WHO and the Institute for Public Health of the Republic of Serbia "Dr. Milan Jovanović Batut", comparative data on coverage of required vaccination against infectious diseases in the Republic of Serbia was provided. Results. The results of a five-year analysis in the Republic of Serbia indicate that coverage of more than 95% was met only with immunization against tuberculosis, while against diphtheria, tetanus and whooping cough, coverage of 95% was until 2019, only to record a decline later. In 2021, a percentage decrease can be seen for all vaccines except the tuberculosis vaccine, and the lowest coverage is for the MMR vaccine (74.8%). In Serbia, in 2020 compared to 2019, the percentage of people vaccinated with the MMR vaccine decreased by 9.9%, i.e. by 3.3% in 2021 compared to 2020, and the data for central Serbia show a decrease of 11.6% in time period from 2019 to 2021. Conclusion. The trend of decline in immunization coverage of mandatory vaccines in Serbia follows the global trend, with the exception of the MMR vaccine, where a significantly greater decline is recorded in Serbia.
Occupational diseases in the Republic of Srpska from 2011-2020
Authors: Marić Nada , Peričević-Medić Sonja , Španović Milorad
Published: April 2023

Background/Aim: The importance of occupational diseases is due to their influence on workers' quality of life and significant socioeconomic problems for the health sector, employers and the state. Occupational diseases are generally not curable but are preventable diseases, so it is extremely important to develop a good system of detection, registration and prevention. Therefore, special attention should be paid to the occupational incidence analysis. Aim of this study was to assess the incidence of occupational diseases in the Republic of Srpska. Methods: The research was conducted as a cross-sectional study based on the obtained data on occupational diseases in the Republic of Srpska for ten years (from 2011 to 2021). Results: In the observed period, 12 cases of occupational diseases were registered in the Republic of Srpska and the incidence was less than 1/100,000 per year. Occupational diseases were diagnosed in: - agriculture, forestry and fishing; - construction and - healthcare and social welfare. Conclusion: The study showed a low incidence of occupational disease and it was observed that certain industrial sectors were particularly undervalued. The current situation regarding occupational diseases in the Republic of Srpska requires an urgent response from the occupational medicine services and the state. It is necessary to initiate procedures as soon as possible to ensure uniformity in the criteria of diagnosis and records of occupational diseases and revision of the list of occupational diseases by the International Labour Organisation. In the future, it is necessary to conduct additional and more detailed research in the field of occupational diseases.
Secoisolariciresinol Diglucoside (SDG) from flaxseed in the prevention and treatment of diabetes mellitus
Authors: Prasad Kailash , Bhanumathy Kalpana
Published: April 2023

This review focuses on the role of reactive oxygen species (ROS) on the development of type 1 and type 2 diabetes and its treatment with secoisolariciresinol diglucoside (SDG) isolated from flaxseed which is an antioxidant and suppresses phosphoenolpyruvate carboxykinase (PEPCK) gene expression, a ratelimiting enzyme in the gluconeogenesis in the liver. Role of ROS in the development of type 1 diabetes [diabetic prone Bio Breeding (BBdp) rats and streptozotocin-induced diabetic (STZ) rats and type 2 diabetes (Zucker diabetic fatty female rats, ZDF rats)] has been discussed. Oxidative stress has been assessed by measuring serum and pancreatic malondialdehyde (MDA), pancreatic chemiluminescence (pancreatic-CL) and oxygen radical producing activity of white blood cells (WBCCL). Diagnosis of diabetes was made by hyperglycaemia and glucosuria. Incidence of diabetes was 100 % in SDZ rats, 72 % in BBdp rats and 100 % in ZDF rats by the age of 72 days. Development of diabetes was associated with increases in the serum and pancreatic MDA, WBC-CL and pancreatic-CL and glycated haemoglobin (HbA1 c). SDG prevented the development of diabetes by 75 % in STZ rats, by 71 % in BBdp rats and by 20 % at 72 days of age in ZDF rats. However, 80 % of the rats which did not develop diabetes by 72 days of age, developed diabetes later on, suggesting that SDG treatment delays the development of diabetes in ZDF rats. Treatment with SDG decreased the levels of serum and pancreatic MDA, WBC-CL and pancreatic-CL. In conclusion, development of type 1 and type 2 diabetes is mediated through oxidative stress and the prevention or delay in the development of diabetes with SDG could be due to its antioxidant activity and its suppressant effect on PEPCK enzyme. Lignan complex which contains 34 % to 38 % of SDG is effective in lowering serum glucose and HbA1 c in type 2 diabetes in humans.
Antioxidative potential of pomegranate peel extract: In vitro and in vivo studies
Authors: Mandić-Kovačević Nebojša , Kukrić Zoran , Latinović Staniša , Cvjetković Tanja , Šobot Tanja , Bajić Zorislava , Maličević Uglješa , Marinković Sonja , Đukanović Đorđe , Uletilović Snežana , Suručić Relja
Published: April 2023

Background/Aim: Due to the numerous beneficial effects of pomegranate that can be explained through its antioxidative effects, the aim of this study was to determine the antioxidant potential of pomegranate peel extract (PoPEx) prepared from pomegranate that was harvested in the southeast region of Herze-govina (Bosnia and Herzegovina), through in vitro and in vivo studies. Methods: In PoPEx total phenols, flavonoids, flavonols, flavan-3-ols and antho-cyanins content was determined, as well as several antioxidative assays, including 2,2 diphenyl-1-picrylhydrazyl assay (DPPH), 2,2'-azino bis(3-ethylbenzothi-azoline-6-sulphonic acid) assay (ABTS), iron (III)-2,4,6-tripyridyl-S-triazine complex assay (FRAP), reduction of copper(II) ions (CUPRAC) assay, Briggs-Rauscher oscillatory reactions, neutralisation of OH radicals and lipid peroxidation assay. In vivo studies were performed by administrating 100 mg/ kg of body weight of PoPEx to the rats by gavage for 7 days, after which the rats were euthanised and prooxidative parameters (thiobabrituric acid reactive substances-TBARS as an index of lipid peroxidation, nitrites-NO 2 , hydrogen peroxide-H 2 O 2 and superoxide anion radical O 2-) were determined in plasma, as well as antioxidative parameters (superoxide dismutase-SOD, reduced gluta-thione-GSH and catalase-CAT) in erythrocyte lysates. Results: High content of phenolic compounds was found in PoPEx, which resulted in high antioxidative potential in all in vitro tests performed. In vivo study showed that PoPEx administration caused a significant decrease in TBARS, NO 2-, as well as an increase in reduced glutathione (p < 0.05) in comparison to the control group, while H 2 O 2 and O 2 * showed a lowering trend and SOD and CAT showed an increasing trend in PoPEx group, but without statistical significance. Conclusion: PoPEx demonstrated high antioxidative capacity measured in vitro and in vivo and can be potentially used as a supplement treatment in the prevention of various inflammatory conditions.
Clinical features and management of human monkeypox
Authors: Moisova Diana , Daguf Vladislav , Grebennikova Maria , Tretyakova Yuliya , Oflidi Georgy , Filonov Anton
Published: April 2023

The COVID-19 pandemic is abating, but the threat of a new epidemic is growing due to the spread of monkeypox in non-endemic regions of the world. In 2022, there were the monkeypox outbreaks throughout Europe, in the Western Hemisphere. With the cessation of the vaccine, due to the global eradication of smallpox, outbreaks of monkeypox have become more common. Currently, there are no exact recommendations for complex treatment and alleviation of the monkeypox symptoms for infected people. Under these conditions, it is especially important to know the pathogenetic mechanisms and epidemiology of the virus for the most effective containment of its spread, especially in view of the negative experience gained in combating the COVID-19 epidemic. The purpose of this study was to summarise the known data on the epidemiology, clinical course and treatment of monkeypox, as well as an attempt to assess the possibility of a new world-spanning pandemic. A targeted search was performed on the keywords "monkeypox", "virology", "Tecovirimat", "Cidofovir", "Brincidofovir" in PubMed, in the period up to July 2022. 661 articles were reviewed, among them as reviews, original research and clinical trials. Preference was given to articles in English that dealt in most detail with cases of monkeypox infection outside the Africa and included comments on the therapy. Seventeen articles were selected and analysed, as well as links within them for additional information on the case. It was revealed that monkeypox is mainly treated with maintenance therapy and the treatment of more complex cases is based on the use of specific antiviral drugs: Tecovirimat, Cidofovir, Brincidofovir. However, there is no widespread therapeutic practice for these drugs. Little is currently known about the monkeypox virus; the transmission of infection, the animal reservoirs, the host range and the prospects for specific treatment are not fully understood. Sharing resources and data with outbreak tracking around the world will greatly facilitate the process of learning about the virus and how to deal with it effectively
Dual practice, factors and solutions for healthcare professionals
Authors: Milošević-Gačević Marijana
Published: April 2023

Dual practice is a phenomenon found in most countries, but it is noticeably more frequent in low-income countries, such as ours. It has been gaining more and more importance lately due to the fact that it may contribute to reducing the already insufficient number of professional health workers in healthcare systems. The reasons that lead to dual practice have not been sufficiently studied. Research results mainly point to economic factors as predictors, but apart from these factors, it is necessary to investigate the prevalence, real consequences, managing this phenomenon, as well as the assessment of the impact of policy measures implemented in this area. Although dual practice is seen as a possible systemic solution to issues such as limited resources (and revenues) in the public sector, low regulatory capacity and the interaction between market forces and human resources, if poorly regulated, it can lead to a conflict of interest as well as resource drain from the public to the private sector. An optimal regulation of the situation and the mobility of health workforce depends on the exceptional circumstances of the country, government capabilities, and the improvement of the health system. At the international level, governments react differently to the phenomenon of dual practice. To recognize the role of dual practice and mobility in the health workforce market, experts advocate more data on dual practice of healthcare workers and the need to integrate these data into national health workforce accounts. The need to develop a national health policy for monitoring dual practice in our country and to develop strategies for mitigating negative effects was highlighted. This paper analyzes the available literature on dual practice, the factors that influence the emergence of this phenomenon, and possible solutions for health workers.
Gender differences at the workplace: Sickness absence and productivity loss at work and their association with health and work-related factors
Authors: Đikanović Bosiljka , Kouwenhoven-Pasmooij Tessa , Kraaijenhagen Roderik , Roeters Van , Burdorf Alex , Vasilev Vladimir , Robroek Suzan
Published: April 2023

Introduction: Differences in sickness absence and productivity loss at work between men and women are recognized but need to be better understood. Materials and methods: In a cross-sectional study, 10,407 employees from 37 companies in the Netherlands participated in a Web-based health risk assessment, between 2010 and 2014. Self-reported short-term (<9 days) and long-term (10 or more days) sickness absences during the preceding 12 months were assessed. The questionnaire also asked about productivity loss at work, physical and psychosocial work-related factors, and health problems. Log-linear models were used to estimate prevalence ratios (PR), with 95% confidence intervals (CI). Results: Women, more often than men, experienced short-term and long-term sickness absence (PR 1.06, 95% CI 1.01 - 1.11, and PR 1.33, 95% CI 1.21 - 1.46, respectively) but were less likely to have productivity loss at work (more than 30%), (PR 0.90, 95% CI 0.81 - 0.99). In short-term sickness absence, gender differences were reduced by 20%, after controlling for psychosocial work-related factors, and by 60%, after controlling for health problems, separately. None of the factors mentioned above could explain a large productivity loss at work among men. Conclusions: Higher prevalence of sickness absence among women can partly be explained by psychosocial work-related factors and health problems. Further studies are needed to explore large productivity loss at work among men.
Neutrino and EM asterometric detection of habitable exoplanets
Authors: Shapshak Paul
Published: April 2023

Discovering habitable exoplanets and exomoons increases the possibility of detecting extraterrestrial life. A bilateral approach, using neutrino and electromagnetic (EM) radiation technologies, can be used to simultaneously characterize star types that generally have exoplanets and exomoons. This includes cool main-sequence, sub-giant, and red-giant stars. Additionally, supernovae, black holes, and neutron and dwarf stars, will be included to widen the investigation, since they sometimes have companions, including stars and planets. Currently, space exploration is advancing beyond the solar system and proliferating into deep space. For this expansion, sophisticated artificial intelligence (AI) is required and being developed for self-coordination and interactive regulation of the various exploratory vehicles and telescopes. [1-6]
Phytochemical screening and anti-obesity, anti- diabetic and anti-oxidant properties of Scoparia dulcis leaf decoction (crude)
Authors: Clara Mary Arulandhu
Published: April 2023

Due to their rising prevalence, diabetes and obesity were both classified as epidemics by the World Health Organization.The natural leaf essence of Scoparia dulcis (S. dulcis), is used as herbal remedy for diabetes and obesity worldwide. However, the objective of the current research was to examine the effects of consuming commercially available S. dulcis porridge on both diabetes and obesity. The S. dulcis plants were collected and the essence was prepared in a traditional way. Phytochemical screening was carried out to identify the secondary metabolites present in the essence. The GC-MS analysis was carried out to identify the bioactive compounds present in the extracts. In order to understand the molecular interaction of identified compounds with selected target proteins from anti-diabetic, anti-oxidant, anti-obesity molecular docking studies was carried out. Results of this docking studies confirmed that identified compounds showed the strong interaction with all the selected target protein. Further experimental analysis is needed to confirm this activity.
A Symbol behind the Image: Reading the Painting by Alexander Volkov
Authors: Abbasova Galina
Published: April 2023

Alexander Nikolaevich Volkov (1886–1957) is one of the Soviet Uzbekistan fine art founders. He actively taught in Tashkent and had a significant impact on the younger generation of the artists. He was a member of the association "New East Masters", headed the informal group "Volkov's Brigade" trying to solve the problems of monumental painting. In addition, the artist's work has some traces of symbolism and impressionism, cubism and primitive art. This article is devoted to Volkov's painting "Teahouse with a portrait of V.I. Lenin”, created in 1928 and stored in The Karakalpakstan State Museum of Art. This picture was painted at a time when the master, in his own words, again turned to human. Therefore the masterpiece corresponded the request to design a new Soviet way of life, to invent the heroes among workers and dekhkans (peasants). However, behind the simple interpretation of "Teahouse", there is a deep symbolism, thanks to which the images go beyond the scope of an ideological statement, turning into a kind of myth. The novelty of this research can be found in the formulation of a problem that has not previously been considered in the scientific literature - the symbolic interpretation of the works of A.N. Volkov of the "socialist realist" period. This symbolic layer in the artist's works is the additional evidence of his sincere passion from the ideas of the cultural revolution and socialist movement in Central Asia. In addition, Volkov's paintings of the late 1920s and 1930s are often overshadowed by his earlier creative experiments. The purpose of this article is to consider and analyze one of the most revealing work belonged to the late period of the artist oeuvre, to identify the semantic layers behind the “tangible breath of the flesh”.
On the Restoration of the Northern Stalls of the Ostankino Estate Amusement Park
Authors: Bairamova Varvara Fedorovna , Isaev Sergei Sergeevich , Samokhina Ekaterina Borisovna
Published: April 2023

The authors discusses the issues that arose when making adjustments to the project documentation with the performance of the function of a technical customer for carrying out repair and restoration work with an adaptation for modern use of windows of federal significance "Ostankino Manor, the end of the XVIII century". The possible ways of solving the problems of creating an image of the garden of its heyday - the end of the XVIII century - the first quarter of the XIX century are presented and analyzed. The arguments justifying design decisions when choosing planting material are demonstrated. The authors focus their attention on this aspect, as one of the numerous markers of the representation of local historical phenomena - in this case, the development of a certain park object. The scientific novelty of the work is connected with the identification of all factors and combinations of planning elements of the estate, which determined the achievement of that aesthetic expressiveness, which determines the status of the object as a cultural heritage and national treasure. We believe that when carrying out new restoration work, it is necessary to raise the question of restoring "flower beds" in historical outlines. In modern conditions, when the scale of the Ostankino park has changed, its functional purpose has changed, it would be wrong to suggest restoring "flowerbeds", while using tree and shrub vegetation. Six "klomps" are formed in accordance with and on the basis of these iconographic materials. The proposed floral assortment is similar to the solutions of the front yard – herbaceous peony (Latin Paeónia), hosta (Latin Hósta), lily (Latin Lílium) and spring flowering ephemeroids.
Tools and Mechanisms for the Implementation of Chinese Cultural Diplomacy towards Russian Federation
Authors: Yang Ziye
Published: April 2023

The article is devoted to the identification and characterization of the main tools and mechanisms for the implementation of Chinese cultural diplomacy in relation to the Russian Federation. The author proceeds from the fact that in the context of the new international situation and a new stage in the development of Sino-Russian relations, the maintenance and intensification of cultural exchanges between the two countries plays an important role. The article emphasizes that the means by which China conducts cultural diplomacy in Russia differ in ways and mechanisms depending on the sphere. It is shown that China's cultural diplomacy in Russia has achieved more significant results mainly in the field of education, literature, artistic cooperation and exchange between the media. Strategic, fateful decisions taken by the top political leadership of the two countries aimed at uniting the two states should be understood and accepted by the population of these countries, which is impossible without a deep mutual understanding of cultural heritage and cultural features. In the article, the author gives numerous examples demonstrating the variety of tools and mechanisms used by Beijing to implement cultural diplomacy in relation to Russia. The author concludes that China uses cultural diplomacy as a means of spreading its culture in Russia, effectively presenting the image of modern China. Cooperation between China and Russia in the field of culture is of great strategic importance for the development of relations between the two countries.