bluuebunny/crossref_metadata_2025 huggingface dataset:
Acrodermatitis Enteropathica-Like Eruption Associated with Parenteral Nutrition
Authors: Katoh Taizo , Igarashi Minoru , Ohhashi Eisuke , Ohi Ryoji , Hebiguchi Tatuzo , Seiji Makoto
Published: October 2009

This is a case report of a patient with acrodermatitis enteropathica-like eruption that occurred during parenteral nutrition. The skin lesions were similar to those of acrodermatitis enteropathica, but there were no other major symptoms such as diarrhea and alopecia. It was noticed that the lack of linoleic acid in the diet might be the cause of lesions.
Therapy of Resistant Psoriasis with Topical Corticosteroids and Dimethylsulfoxide
Authors: Kaidbey Kays
Published: October 2009

The sequential application of full-strength dimethylsulfoxide (DMSO) and potent topical corticosteroid preparations was very effective in resistant plaque-type psoriasis. Complete clearing may be achieved in 3–4 weeks. Lower strengths of DMSO were less beneficial. Irritation from the solvent was effectively controlled by corticosteroids and was limited to transient burning or stinging. Resistance to topical corticosteroids may be overcome by the concomitant use of DMSO.
Dermic Peripheral Microangiopathy in Plasmo-Proliferative Disorders
Authors: Valdés Eduardo F. , Herrero Maria V. , Calb Ignacio , Vazquez Ricardo
Published: October 2009

Skin biopsy specimens from 12 patients with plasmo-proliferative disease (myeloma and macrogobulinemia) were histopathologically and histochemically examined. In all the cases studied (by a biopsy obtained from the hand) there were alterations in the dermal microvasculature characterized by thickening of the PAS-stained basal membrane, endothelial swelling and proliferation with partial obliteration of the vascular lumen. The lesions were morphologically similar to those found in diabetic and paralymphomatous microangiopathy but in the present investigations greater endothelial proliferation has been observed. We did not find any lesions in the healthy control group. Different immunological, metabolic and hyperviscosity mechanisms are discussed. It is interesting to report that the results for blood coagulation and carbohydrate metabolism were normal; hyperviscosity was found in the serum of the patients examined, and in 3 cases cryoglobulinemia was also found. It will be interesting to carry out further investigations on the different pathogenic and biological aspects of the skin microvascular lesions in plasmo-proliferative diseases in order to increase our knowledge of the microcirculation in immunologic malignant disorders.
Bullous Pemphigoid Controlled by Dapsone
Authors: Piamphongsant Thada , Ausawamongkonpan Somchit
Published: October 2009

Three uncomplicated cases of bullous pemphigoid, confirmed by histology and immunofluorescent studies, responded to dapsone.
Pemphigus Vulgaris Following D-Penicillamine
Authors: From Ellis , Frederiksen Poul
Published: October 2009

A 54-year-old woman with systemic sclerosis developed clinical, histo-pathologic and immunopathologic findings consistent with pemphigus vulgaris after 8 months treatment with D-penicillamine. The course of the bullous disease required sustained steroid treatment.
Syphilis, Homosexuality and Legislation
Authors: Suhonen R. , Wallenius J. , Haukka K. , Elo O. , Lassus A.
Published: October 2009

The proportion of cases with fresh syphilis in males contracted by homosexual contacts in Helsinki before and after the change of the criminal law in 1971 was studied. Since 1971, homosexuality is by law no longer a crime in Finland. In 1964, only 2% of males with fresh syphilis admitted a homosexual contact. The same figure was 8% in 1970, and increased to about 50% in 1974 and 1975. It was concluded that a change of legislation concerning homosexuality, probably by several different routes, changed the proportion of cases of detected homosexually transmitted early syphilis. This was thought to be of special importance for case finding and controlling of the spread of syphilis.
Diffuse Biphasic Amyloidosis
Authors: Piamphongsant Thada , Kullavanijaya Preya
Published: October 2009

Disseminated cutaneous amyloid deposits were found in four Thai patients who had unusual diffuse skin pigmentation covering the skin surface of the entire body. They also had lichenoid lesions on the pretibial areas and hypomelanotic macules on the extremities.
Depigmenting Action of Corticosteroids
Authors: Arnold J. , Anthonioz P. , Marchand J.P.
Published: October 2009

The depigmenting action of corticosteroids was studied on the black skin of the guinea-pig by cutaneous applications followed by repeated histological sections. These experiments demonstrated the depigmenting action of triamcinolone acetonide and betamethasone 17-valerate. The results of this study show the influence of concentration and chemical formula of the corticosteroids on the process of depigmentation. The histological study did not reveal any particular morphological aspect of melanocytes capable of suggesting a mechanism of action by these chemical compounds at the cellular level.
Zur Ultrastruktur des soliden Basalioms
Authors: Rupec M. , Kint A. , Himmelmann G.W. , Brühl R.
Published: October 2009

A morphometric investigation was made on mitochondria of basalioma cells and the cells of the basal layer of the epidermis lying over the tumor. The mitochondria of the basalioma cells occupy 4.7% and of the epidermal basal cells 5.3% of the cytoplasm. The number of mitochondrial sections yields a relation of 6.6:10 in favor of the epidermal cells. These results demonstrate an alteration in the size of the basalioma cell mitochondria. The possible causes of this mitochondria enlargement were discussed. An attenuation of the activities of the mitochondrial, membrane-bound enzymes in the basalioma cells is caused in all probability primarily by a reduction of the cristae material in comparison to the basal epidermal cells. The nucleus-cytoplasm relation amounts to 6.3:10 in the basalioma cells and 3.0:10 in the basal epidermal cells.
Botryomycosis
Authors: Martin-Páscual A. , Pérez García
Published: October 2009

A case of botryomycosis was studied in which a coagulase-negative, DNAse-negative Staphylococcus with wide antibiotic sensitivity in vitro was isolated and which could be classified as having a ‘low pathogenic capacity’. Nevertheless, there was no improvement with appropriate therapy. IgG and complement (C3) were demonstrated in the grains. Botryomycosis can be considered as a state of ‘equilibrium’ between the host and the microorganism. It is not clear if this results from low pathogenicity of the organism or from some peculiar characteristic of the host.
Studies on the Species, Amount and Base Composition of Nucleic Acids in Psoriatic Scales and Normal Horny Layer
Authors: Peter G. , Brand A. , Peter R.
Published: October 2009

The amount of RNA as well as DNA is considerably increased in psoriatic scales as compared with normal horny layer; RNA was characterized as a low-molecular tRNA; as concerns the base composition of DNA, no particularities in comparison with other DNA species were found, and the base composition of tRNA revealed that cytosine and guanosine are in excess; pseudouridine could not be detected in psoriatic tRNA.
Nature of the Sweat Glands in the Hairy Skin of the Beagle
Authors: Cotton D.W.K. , van Hasselt P. , Bergers A.M.G.
Published: October 2009

The local pharmacology, the thermal response and the response to hypothalamic stimulation of the sweat glands of the hairy surface of the beagle are described. The results, together with those of electron-microscopic examinations, support the idea that these sweat glands are apocrine and are not directly innervated. No clear relationship with thermoregulation could be found and a pheromonal function is tentatively suggested.
Miconazole Nitrate in the Treatment of Dermatomycoses
Authors: Degreef H. , Verhoeve L. , van Cutsem J.
Published: October 2009

Miconazole nitrate was used topically in 83 dermatophytic and candidal infections. Complete cure was obtained in 81% of the cases. The in vitro studies made before, during and after treatment showed no evidence of resistance to the drug. The miconazole 2% cream and powder preparations were well tolerated. Only one case of sensitization was observed.
Umbilical Polyp: a Report of Two Cases
Authors: Hejazi Nosratollah
Published: October 2009

Two cases with umbilical polyp are reported. This rare malformation arises from remnants of the omphalomesenteric duct and may be clinically mistaken for a granuloma pyogenicum or other benign or malignant umbilical neoplasms. Histologically umbilical polyp shows branching glandular structures lined by intestinal mucosa in connection with the surface of the skin. When the umbilical polyp is not associated with any other types of underlying abnormalities, it may be treated by a simple surgical excision.
Pretibial Epidermolysis bullosa: Report of Two Families and Review of the Literature
Authors: García-Pérez A.G. , Carapeto F.J.
Published: October 2009

Two pretibial epidermolysis bullosa families, with a total of four cases directly examined and another eight cases known from references, were studied. Both families showed an autosomal dominant inheritance. In one family there was a case of ‘bullous epidermolysis albo-papular of Pasini’. All cases were compared with those of the literature.
Psoriasis: A Review. II
Authors: Baker Harvey
Published: October 2009

Notwithstanding the intense interest in systemic cytotoxic therapy in recent years, the great majority of psoriatics are likely to go on needing topical therapy with tar, dithranol or corticosteroids, and a welcome trend is the spreading of interest in day care centres such as those in Paris (Grupper), Stockholm (Thyresson), Stanford (Farber) and San Francisco (Cram) evolving from the out-patient regimes advocated by Ingram in Leeds a generation ago.
Untersuchungen zum Wirkungsmechanismus von Dithranol: Erhöhte Lipidperoxydation und Enzymhemmung
Authors: Diezel Wolfgang , Meffert Hans , Sönnichsen Niels
Published: October 2009

The results reported in connection with previously published data suggest the importance of increased lipid peroxidation in the epidermis after Dithranol treatment. Malonaldehyde, one of the main products of lipid peroxidation, reacts with epidermal phosphofructokinase and glucose-6-phosphate dehydrogenase to cause enzyme inactivation by cross-linking of the enzyme protein demonstrated by dodecyl sulphate electrophoresis. Enzyme inactivation leads to an inhibition of hexose monophosphate shunt and glycolysis. The effect on energy donating metabolism in psoriatic lesions is discussed.
Elastosis senilis hyperkeratotica striata
Authors: Korting G.W. , Hoede N.
Published: October 2009

‘Senile and striate hyperkeratotic elastosis’ is described and discussed as a new peculiar type of colloid atrophy of the skin in the skull of the aged.
Dyskeratosis Congenita
Authors: Wang S.R. , Wong C.K.
Published: October 2009

A case of dyskeratosis congenita in a Chinese boy is reported. The clinical and laboratory findings are discussed.
Mode of Dermal-Epidermal Adhesion
Authors: Omar A. , Krebs A.
Published: October 2009

The mode of dermal-epidermal adhesion was investigated by a systematic enzyme digestion of the dermo-epidermal junction. The anchoring fibrils and filaments were found to consist of elastin and collagen-like filaments which intertwine to form the adepidermal membrane. A model on the possible in situ conditions is proposed.
Protection against Long Ultraviolet and/or Visible Light with Topical Dihydroxyacetone
Authors: Fusaro Ramon M. , Johnson John A.
Published: October 2009

Dihydroxyacetone (DHA) chemically induces long ultraviolet (UV) and/or visible photoprotection into the stratum corneum as demonstrated by (a) long UV protection of albino rats which were psoralen-photosensitized to black fluorescent light and (b) sunlight protection of five patients with long UV and/or visible photosensitivity. Previously, DHA treatment of skin was considered to provide no protection against UV. For clinical use, the combination of DHA and lawsone (2-hydroxy-1,4-naphthoquinone) is preferred to DHA alone, because it provides rapid, positive protection over a range extending from short UV into the visible region of sunlight.
Skin Surface Retention of an Applied Ointment
Authors: Hellgren Lars , Vincent Jan
Published: October 2009

A routine method using quantitative thin-layer chromatography for the determination of the retention time of an applied ointment on healthy and psoriatic skin is described. The retention time of the ointment was longer on the diseased skin than on the healthy skin. The method is thought to be of practical value in cosmetology and clinical dermatology.
Treatment of Discoid Lupus Erythematosus with Betametasone-Valerate Cream 1%
Authors: Reymann F.
Published: October 2009

A report is presented of a 5-year clinical trial during which 78 patients suffering from discoid lupus erythematosus were treated with 1-percent betametasone 17-valerate in an oil/water emulsion cream. In 10 cases, local treatment had to be supplemented by the oral administration of chloroquine for shorter or longer periods. On the whole, this therapy represented a great advance, the majority of the patients being kept completely or almost completely free of symptoms by means of local treatment alone. No steroid-induced atrophy of the epidermis was observed. It should be emphasized that the patients were checked at intervals of a few months and were carefully instructed as to the procedure to be followed during the local treatment.
Chemical Composition of Hair Melanosomes
Authors: Borovanská»³ J. , Duchoň J.
Published: October 2009

The chemical composition of isolated human hair melanosomes was studied. It was found that hair melanosomes contained 60.54 ± 3.99% of melanin which puts them among the most melanized particles. The amino acid analysis revealed all 18 usual amino acids in the hydrolysate, whereas DOPA could not be found. These data were compared with those of melanosomes isolated from human malignant melanoma.
Das Klarzellakanthom
Authors: Ebner H. , Erlach E.
Published: October 2009

In the last 6 years, 10 patients with a total of 17 clear-cell acanthomas were observed. All lesions but one were located at the legs. On the basis of this material the typical clinical picture as well as the histology and ultrastructure of these tumors is described.
Fokale epitheliale Hyperplasie der Mundschleimhaut: Hecksche Krankheit
Authors: Orfanos C.E. , Strunk V. , Gartmann H.
Published: October 2009

Three children from Turkey were observed, showing an unusual hyperplasia of their oral mucosa, corresponding to focal epithelial hyperplasia (FEH), described by Heck. These are the first cases of Heck’s disease registered in the Federal Republic of Germany. The lesions in FEH are multiple, painless, soft papules of the oral mucosa. In all cases the lower lip was involved. The etiology of this rare condition is still unknown. Our investigations with electron microscope failed to confirm the presence of a virus in the lesions. Local application of vitamin A acid seems justified, since the lesions disappeared after this treatment in two cases. Spontaneous remissions are recorded.
Antigen Dd Reactors in an Indian Population
Authors: Kaur Narinder , Shrivastava Prabodh K.
Published: October 2009

Saline extracts of human dandruff contain a factor, antigen Dd, which precipitates human sera selectively. There is a significant excess (p < 0.001) of antigen Dd reactors among the Punjabi blood donors of India as compared to the blood donors of Poland. Laboratory analysis of assorted hospital sample shows that antibodies to antigen Dd are present more often in autoimmune than in other diseases.
Zur Frage der transepidermalen Ausscheidung von Nävuszellnestern
Authors: Rupec M. , Vakilzadeh F.
Published: October 2009

A transepidermal elimination of junctional nests could be demonstrated in 8 out of 65 junctional active nevus cell nevi (i.e. in 12%).
Effects of DMBA on Melanocytes in Culture
Authors: Klaus Sidney N.
Published: October 2009

The carcinogen, dimethylbenzanthracene (DMBA), selectively destroys guinea pig melanocytes in vitro. Cytotoxicity of DMBA appears to be unrelated to the pigmenting capacity of the cells.
Lentiginoses et anomalies de développement
Authors: Niţelea Olga Galaction , Dociu Igor
Published: October 2009

The present paper reports on a family (2 parents and 3 children) with a minor hereditary polydysplasia: lentiginosis on the face or body, psychic disturbances (oligophrenia, psychopathy) and behavioral troubles, dysraphia (with enuresis up to the age of 8–16 years in the children), strabism and dyscrinism. The EEG was altered in 3 of 4 cases. The three caryotypes performed were normal. The mode of transmission was dominant. The authors review the observations of lentiginosis, published in the medical literature; there is almost always an association with other developmental anomalies; sometimes there are also neuropsychical disturbances. Therefore, the lentiginosis can be generally considered as the cutaneous signature of polydysplasic, often heredo-familial syndromes.
Technische Verbesserung der Fernbestrahlung
Authors: Jung E.G. , Schnyder U.W.
Published: October 2009

The special techniques required for performing X-ray distance irradiation with the ‘Dermopan’ (Siemens) have been described with emphasis on perpendicular radiation.
Hydropic Degeneration of Epidermal Keratinocytes
Authors: Frenk E. , Delacrétaz J.
Published: October 2009

Report of 2 patients with brownish, ill-defined macules on their fingers, in one case also on elbows and knees. Light microscopy revealed identical changes in both cases: scattered, swollen, vacuolated, clear keratinocytes in the suprabasal epidermis and horny layer. Electron microscopy showed alterations which were interpreted as hydropic degeneration of keratinocytes.
Lichenoid Tri-Keratosis (Kaposi-Bureau-Barrière-Grupper)
Authors: Aguadé Joaquín Piñol , de Asprer José , Ferrando Juan
Published: October 2009

A case of peculiar eruption in a 43-year-old man is reported. The eruption was papular, polymorphic, hyperkeratotic, and lichenoid appearing on 4dry skin with patches, linear striation and Sverrucous hyperkeratosis. The histological picture showed a lichenoid lymphohistiocytic infiltrate with hyperkeratosis, hypergranulosis and parakeratosis ‘in cutem penetrans’. The general examination and laboratory findings were normal. Only seven cases have been previously reported. The first one was described by Kaposi, and in four of them there were also mucosal lesions. The differential diagnosis is made with the hypertrophic lichen planus and with the lichen of toxic origin.
Bromoderma in Pregnancy
Authors: Parish Charles Lawrence , Polin Joel I.
Published: October 2009

A 33-year-old white woman, gravida 6, para 5, abortus 0, developed bromoderma during the sixth month of her pregnancy. She had ingested approximately 30 capsules of Nervine® per day for the previous three months. She responded to treatment and a normal male infant was born at term.
Klinik und Therapie der anogenitalen Hidradenitis suppurativa
Authors: Scherrer A.
Published: October 2009

Three patients with anogenital hidradenitis suppurativa who had failed to respond to prolonged medical treatment were cured by radical surgery which included excision of the subcutaneous tissues down to the plane of the musculature. One patient was found to have an anal fistula. The extensive skin defect was allowed to be covered by clean granulation tissue before plastic repair was attempted. Patients were kept in hospital for 2½ to 3½ months. There was no relapse up to 16 months and 6 months respectively after the operations.
Granuloma annulare und Rheumatismus
Authors: Eichmann T.
Published: October 2009

The histological relationship between granuloma annulare (GA) and rheumatoid nodules induced the authors to subject 50 patients with GA to a thorough anamnestic and clinical examination, which would permit recording a possible increase in rheumatic morbidity. No connection was found between GA and inflammatory rheumatism. The investigation revealed a great number of degenerative rheumatic affections, which was in accordance with the Swiss epidemiological study of a healthy population. The only difference apparently is, that more frequently in patients with GA an earlier degenerative rheumatic ailment is observed. In order that this difference be considered significant, it would be necessary to examine at least 150 patients. In analogy to rheumatic and rheumatoid nodules in inflammatory rheumatism, the question remains, whether GA could possibly count as a conditional clue for an early occurring form of degenerative rheumatism, and can be considered as a degenerative rheumatic lesion of the skin without an obligatory equivalent systemic disorder.
Chirurgische Therapie des diabetischen Malum perforans
Authors: Graber W. , Häfliger M. , Krebs A.
Published: October 2009

The healing process of two patients with diabetic malum perforans is casuistically reported. The conservative therapy showed no improvement of three trophic ulcers, even after several months of treatment. However, a rapid healing was observed after surgical excision and suture.
Protection against Long Ultraviolet Light with Dihydroxyacetone/Naphthoquinone
Authors: Johnson John A. , Czaplewski Rodney R. , Fusaro Ramon M.
Published: October 2009

An earlier report described a technique for assessing long ultraviolet (UV) phototoxicity, based on measurement of increased paw weight of psoralen-sensitized rats after exposure to black light. The procedure was modifled and employed to demonstrate that dihydroxyacetone/naphthoquinone (DHA/lawsone) protects sensitized rats against light. The observed effectiveness of DHA/lawsonein the animal model agreeswith our clinical success in protecting photosensitive patients against long UV light.
Dermatomyositis and Lichen Myxedematosus
Authors: Johnson Bernett L. , Horowitz Robert I. , Charles Robert , Cooper David L.
Published: October 2009

The association of lichen myxedematosus and dermatomyositis is uncommon. The patient in this study developed cutaneous mucinosis several years before the myositis. Histological and histochemical studies confirmed the diagnosis of a mucinosis and myositis, and showed that the fibroblast plays a significant role in the production of the skin lesions.
Immunotherapy of Superficial Dermatomycoses
Authors: Tager A. , Lass N. , Avigad J. , Beemer A.M.
Published: October 2009

The long-range efficacy of the standard treatment for superficial dermatomycoses is, in the majority of cases, unsatisfactory, even despite the advent of griseofulvin. The present paper reports an attempt to treat patients suffering from superficial dermatomycoses (Monilia and tinea) by specific immunotherapy. The follow-up period on patients receiving a full course of immunotherapy was 18 months. Of 39 patients receiving immunotherapy with Trichophyton as antigen, 22 were cured completely and an additional 4 showed partial cure (skin lesion healed but nails unaffected). Of 24 patients treated with Monilia antigen, 15 recovered completely. These results, although based on a limited number of cases, are fairly encouraging and point to immunotherapy as an additional method in the treatment of superficial dermatomycoses.
Interpretation pathogénique de l’extension des placards de psoriasis
Authors: Brassinne M. , Pierard G.
Published: October 2009

The extension border of lesions of psoriasis vulgaris has been studied by histogeometric analysis of the epidermis and by autoradiography after in vitro incorporation of tritiated thymidine. The first modification observed is a hyperactivity of in the suprabasal layer associated DNA-synthesis with band-like acanthosis. Later, the basal labelling index is increased and the germinative compartment is exponentially enlarged by extension to more superficial layers, each of them reaching progressively the level of thymidine incorporation in the preceding one. These modifications could result from a defect of cellular differenciation perhaps through a decreased receptivity of the psoriatic epidermal cells to some inhibitory factors and a progressive selection of this population.
Pemphigus Erythematosus Confined to the Post-Burn Scar
Authors: Kudejko J. , Buczkowska J. , Trzebuchowska T.
Published: October 2009

The authors present a case of pemphigus erythematosus with the lesions confined to the post-burn scar. Histological examination showed some features of lupus erythematosus and a typical acantholysis in superficial layers of the epidermis, as well as in the hair follicles. Immunofiuorescent studies have revealed circulating pemphigus antibodies in a titre of 1:80 and in the lesions the presence of in vitro bound immunoglobulins G (IgG) in the intercellular spaces, as well as at the epidermal-dermal junction. A possible pathogenetic relationship between the burn and pemphigus erythematosus is discussed.
Reflex Sympathetic Dystrophy
Authors: Menke H.E.
Published: October 2009

In dermatological literature there is a great paucity of publications on reflex sympathetic dystrophy. A case history and a short review are presented. The variety of apparently unrelated clinical syndromes, terminology and therapy are discussed. It is generally assumed that a high sympathetic outflow, caused by short circuit is the basic mechanism underlying these syndromes. Treatment is directed at interrupting the high sympathetic outflow by means of ganglion blockade.
Persistent Papules After Tick-Bites
Authors: Yesudian Patrick , Thambiah Arthur S.
Published: October 2009

The authors describe the clinical and histological appearances and treatment of a case of tick-bite prurigo. Excellent clinical improvement was obtained to intralesional steroid therapy while all other modes of treatment failed to afford symptomatic relief.
Microangiopathy in Cases of Granuloma annulare
Authors: Haim S. , Shafrir A. , Haim N. , Lichtig C.
Published: October 2009

10 of 16 (62.5%) patients with granuloma annulare presented microangiopathic changes in the skin. The incidence in control groups was 100% in diabetic patients, 40% in old-age patients not known as diabetics and 0 in young victims of road accidents. The frequency of the vascular findings does not seem to be shared equally by the two types of granuloma annulare, the generalized and the localized type. In the first, as in the diabetic group, microangiopathy was observed in all patients examined. Whereas, in the second it was detected in only 2 of the 8 patients. It is concluded, therefore, that from the point of view of their relation to a diabetic state, the two forms of the disorder differ from each other.
Heat, Humidity and Pyodermas
Authors: Singh Gurmohan
Published: October 2009

The effect of humidity and atmospheric heat on the incidence of pyodermas was studied by recording the out-patient department attendance of these patients and general skin attendance and correlating the percentage with the climatic variations. There was a definite increase in incidence of pyodermas during the months of June, July and August. During this period atmospheric temperature and relative humidity were also fairly high. The hydration of stratum corneum, which in turn is influenced by heat and humidity, is responsible for excessive growth of bacteria and higher frequency of pyogenic skin infections.
Acquired Ichthyosis in Kaposi’s Sarcoma
Authors: Krakowski A. , Brenner S. , Covo J. , Loewenthal M. , Baratz M.
Published: October 2009

A case of Kaposi’s sarcoma with associated ichthyosis is presented. Kaposi’s sarcoma should probably be added to the conditions in which acquired ichthyosis is bound to occur.
Third Component of Complement (C3) and Fourth Component of Complement (C4) in Discoid and Systemic Lupus erythematosus
Authors: Risum Gunver
Published: October 2009

In 54 patients with lupus erythematosus – 6 with systemic, 19 with disseminated discoid, and 29 with localized discoid lupus erythematosus determination of the 3rd and 4th components of complement (C3 and C4) was performed in a prospective study. In relation to 42 healthy persons, the mean value of C3 proved significantly reduced in systemic lupus erythematosus, and the mean value of C4 was significantly reduced in systemic as well as in disseminated discoid lupus erythematosus. When C3 and C4 were related to disease activity, a depression of complement was found parallel to an increase in disease activity in all three forms of lupus erythematosus. Compared with other serological tests, C3 and C4 afforded the best serological evaluation of the disease activity. Alterations in the clinical condition in 8 of the patients with discoid lupus erythematosus were preceded by changes in C4. A single determination of C4 was diagnostic in 8% of the patients with discoid lupus erythematosus.
Mitteilungen – Communications Was leistet die mykologisch-kulturelle Untersuchung?
Authors: Fischer Emil
Published: October 2009

The clinical usefulness of 3278 mycological cultures obtained from skin lesions has been assessed. This number represents the requests for mycological identification at the University Dermatology Department in Zurich during 1972. Most specimens were obtained from skin, nails and hair, but blood, faeces, urine and pus were also submitted. Among the dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes were most commonly found and Candida albicans in the yeast group. Cultures were positive more often than direct microscopic examination in all specimens. This was particularly striking with sputum and hair specimens. In view of the time-consuming techniques and the inevitably long delay in obtaining laboratory identification of pathogenic fungi in dermatology requests for identification seem to be justified only if required for diagnosis and treatment in particular of nail infections with Griseofulvin. If fungi can be demonstrated microscopically their identification by culture is rarely necessary and microscopy should always be undertaken by the clinician. In systemic mycoses laboratory identification of the infecting organism is essential.
Spätresultate von bestrahlten Plantarwarzen
Authors: Faessler R. , Krebs A.
Published: October 2009

100 of 250 patients treated for plantar warts with an irradiation dosage of 3–4 × 1000 r/ 50 kV/1.0 mm Al were reexamined after an average interval of 11.3 years. The following results were obtained in the 91 patients who were cured by this treatment: 7 patients showed serious post-irradiation damage; in 2 patients recurrence had taken place; 31 revealed slight X-ray changes of the skin, whereas in 51 patients no pathological changes by irradiation could be detected
Contact Sensitivity in Stasis Dermatitis
Authors: Rudzki Edward , Baranowska Elżbieta
Published: October 2009

A large group of contactants was found to yield positive patch tests much more often in stasis dermatitis than in other forms of dermatitis. Most of these substances were topically applied medicaments and aromatic amines. Positive tests for the other contactants (including potassium dichromate, nickel sulphate, cobalt chloride, mercaptobenzothiazole, tetramethylthiuram disulphide and formaldehyde) were not significantly more frequent in stasis dermatitis than in other forms of dermatitis.
Delayed Cutaneous Metastases of Mucus-Producing Cell Carcinoma of the Stomach
Authors: Feuerman E.J. , Nir M.A. , Lurie Miriam
Published: October 2009

A patient presented with an infiltrate resembling scleromyxoedema Arndt-Gottron which proved to be metastatic signet-ring cell carcinoma of the stomach. Later, round infiltrates appeared on the trunk. The primary lesion was excised 9 years previously and the cutaneous involvement was the sole manifestation of the process for more than a year. Most skin metastases of gastric carcinoma fall into three groups: generalized, by hematogenic dissemination; periumbilical; and those spreading by lymphatics to neck, head and upper thorax. The morphology may in some cases give a clue as to the histological composition of the infiltrate. In our case the scleromyxoedema-like morphology was due to production of mucus by the carcinoma.
Identifizierung «atypischer» Adeninabbauprodukte isolierter Epidermis haarloser Mäuse
Authors: Schwarz E. , Berger M. , Pech H.
Published: October 2009

Two metabolites of 14C-adenine, found by incubation with separated epidermis of hairless mice, show the same behaviour in column or paper chromatography, as those produced by the action of commercial xanthine oxidase. Therefore, also because of the characteristic ultraviolet spectrum of one of the metabolites, they can account for direct products of adenine oxidation: 8-hydroxyadenine and 2,8-dihydroxyadenine. In the experiments with isolated epidermis, the build-up of these metabolites is due to the deficiency of deaminate adenine. The relevance of such a ‘bypath’ of adenine breakdown in the epidermis in vivo is discussed.
Lichenoid Sarcoidosis with Myocardial Involvement
Authors: Harari Z. , Feinstein A. , Schewach-Millet M.
Published: October 2009

A case of systemic, progressive sarcoidosis with a specific histology of skin and lymph node, a positive Kveim test and a typical radiograph of the lungs, as well as good evidence of specific myocardial involvement is presented.
Hypertrichosis lanuginosa acquisita
Authors: van der Lugt L. , de Wit Dudok
Published: October 2009

Two cases of hypertrichosis lanuginosa in female patients with carcinoma of the colon and the rectum, respectively, are described. In 6 of the total of 9 cases reported, this syndrome occurred in association with internal malignancy.
Liver Biopsy in Psoriasis
Authors: Zachariae H. , Søgaard H.
Published: October 2009

147 liver biopsies were performed in 79 patients with severe psoriasis, 18 patients with Parkinson’s disease, and post mortem in 42 patients following sudden death from cardiac failure or traffic accident. 47 of the biopsies in psoriatics were performed prior to treatment with methotrexate. 40 biopsies were taken during treatment. A high incidence of pathological findings were found in both groups of psoriatics. Fatty metamorphosis, periportal inflammation, and focal necroses were found in statistically higher degree among psoriatics than among controls. It is suggested that besides being due to presence of obesity, drug exposure, and alcohol intake, liver pathology in psoriatics may be associated with the disease itself. No statistically significant differences were found between the two groups of biopsies from psoriatics.
Histologische und elektronenmikroskopische Befunde bei Histiocytosis gigantocellularis (multizentrischer Retikulohistiozytose)
Authors: Haustein U.-F. , Thormann T. , Klug H. , Friedrich Carla
Published: October 2009

Histological and electron microscopic examination has been carried out on the biopsies from a patient with histiocytosis gigantocellularis. The following findings have been observed. (1) The cells of histiocytosis gigantocellularis have characteristic granules of different size, form, and electron density, mostly showing a lamellar structure, as well as a membranous limit. These granules are probably synthetized within the cells. Their chemical composition and function are unknown. (2) Similarity between the electron-dense granules and those of Merkel’ cells, as well as the richness of unmyelinic nerve fibers in the immediate environment of the granuloma cells are discussed. Desmosomal structures have not been observed, but there are many cytoplasmic processes which are cogged in labyrinth-like fashion, partly forming a membranous complex. (3) The fine structure of the nucleolus, a well-developed endoplasmic reticulum, as well as a large amount of microfibrils and intracellularly localized collagen fibrils are features of fibroblasts, and may possibly be a transition stage of the granuloma cells. It is supposed that granuloma cells represents a degree of differentiation between reticulum cells and fibroblasts on the one hand and histiocytes (macrophages) on the other. Enlarged hollows are interpreted as a phagocytotic phenomenon of storing of lipids. (4) The nature of the stimulus leading to the formation of systematized giant cell granuloma is thus far unknown.
Serum Insulin and Growth Hormone Response to Arginine Infusion in Healthy and Psoriatic Persons
Authors: Hopsu-Havu V.K. , Niinikoski A. , Haapalahti J.E. , Jansén C.T.
Published: October 2009

Serum insulin and growth hormone responses to intravenous infusion of arginine were measured in 10 normal control persons and 13 age- and weight-matched nondiabetic psoriatics. The average peak insulin levels, 58.2 μU/ml for normal controls and 47.8 μU/ml for the psoriatics, were recorded at 30 min. The average growth hormone peak values, 20.1 ng/ml for normal controls and 17.8 ng/ml for the psoriatics, were recorded in most cases in 60 min. No significant differences were obtained between the normal controls and psoriatics.
Über die Nebenwirkungen der Bleomycintherapie auf der Haut
Authors: Kiefer O.
Published: October 2009

Report on 18 patients showing skin manifestations under bleomycine therapy. These side effects may already become manifest at a total dosage of 90 mg. In order of frequency, the following side-effects are found: hair-loss, swelling of skin and joints, hyperkeratosis, pigmentations and stomatitis. These side effects are reversible and hardly ever necessitate the interruption of therapy.
Fixed Drug Reaction Provoked by Small Differences in Chemical Structure
Authors: Jorgensen Finn
Published: October 2009

A fixed drug reaction following the intake of sulfametomidinum NFN was activated by renewed intake of the drug but not by the ingestion of the almost identical sulfametorinum NFN.
Zur IF-Diagnostik der Gonorrhö
Authors: Rufli T.
Published: October 2009

The increase in gonorrhoea demands more thorough diagnostic measures. In 160 patients with urethritis and 60 female patients with various symptoms suggestive of gonorrhoea 3 different diagnostic methods (Gram staining, direct IF-test, cultural growth on Thayer-Martin medium) were compared. In the 160 male patients the 3 methods showed convergent results in 93%. The 10 cases yielding divergent results are discussed. In the 60 female patients the results were convergent in 86% from urethral smears, in 76% from cervical smears respectively. In 17 women gonorrhoea was diagnosed, 11 times with all 3 methods, 4 times with the culture and IF-test, twice with the IF-test alone. Comparing the results of the 3 methods, the IF-test has advantages both in use of time and equipment and has proved to be the most specific test in our experiments.
Fucidin in Psoriasis
Authors: Nyfors A.
Published: October 2009

The sodium salt of fucidic acid, fucidin, an antibiotic, was given in a dosage of 250 mg t. i. d. to 20 patients with psoriasis vulgaris in a double-blind study over two periods of four weeks each. No adjunctive therapy was allowed the patientsexcept for use of an indifferent ointment, Vaselin aquosum (Pharmaconopea Danica). Patients with recent infections were excluded. No statistical significant effect of fucidin in terms of clearing of psoriasis was found. To rule out new, fashionable drugs for ‘clearing psoriasis’, the importance of a strictly run double-blind study is emphasized.
A Case of Letterer-Siwe’s Disease
Authors: Johansen A.G.
Published: October 2009

The paper gives a report of a case of Letterer-Siwe’s disease, deals with certain dermatologic problems concerning the diagnosis, emphasizes the value of modern treatment, and points to the possibility of encountering mild forms of the disease.
Pityriasis rubra pilaris with Muscle and Joint Involvement
Authors: Aguilar A.R. , Gomez F. , Balsa F.T. , Framil J.P. , Oubina P.N.
Published: October 2009

A case of pityriasis rubra pilaris (PRP) is presented, of the erythrodermic type, with typical keratotic follicular papules and late onset. Muscle and joint symptoms and laboratory findings suggestive of a connective tissue disorder were also present. The patient’s skin manifestations cleared with vitamin A and prednisone therapy. The concept is advanced that PRP is not only a cutaneous disease but possibly a more generalized one, at times presenting with involvement of other systems.
Poikilochromia alba (Albinismus circumscriptus)
Authors: van Velde J.L.
Published: October 2009

Two families with a striking dominant hereditary disorder of pigmentation, poikilochromia alba (albinismus circumscriptus) are reported. The pigmentary changes and the heredity basis of this disorder are described and the pathogenetic difference from vitiligo and albinismus universalis is discussed. As a better name for this disorder, the term poikilochromia alba is proposed.
Ultrastrukturelle Unterscheidungsmerkmale von autosomal-dominanter Ichthyosis vulgaris und X-chromosomal rezessiver Ichthyosis
Authors: Anton-Lamprecht Ingrun , Hofbauer Mechtild
Published: October 2009

Ultrastructural evidence is presented for significant distinction of autosomal dominant ichthyosis vulgaris (ADI) and x-linked recessive ichthyosis (XRI). In the case of ADI a severe disturbance of keratohyalin synthesis reults in a largely reduced deposition of minute abnormal keratohyalin granules of crumbly appearance; on the contrary, keratohyalin in XRI is synthesized in normal or increased amounts. The mode of inheritance has been confirmed by genetic analysis of the patient’s families.
Clear Cell Melanoblastoma
Authors: Hůla M.
Published: October 2009

In a 37-year-old male, a melanoblastoma was observed consisting for the most part of clear vacuolated cells. The tumour cells in the lymph node metastasis were of common appearance typical for melanoblastomas of the alveolar type. The presence of clear cells can be misleading in the establishment of the accurate bioptic diagnosis. The behaviour of the clear cell melanoblastoma shows no difference from other types of this tumour. No definitive explanation of clear cell transformation in melanoblastomas is given at present.
Role of Keratinases in Dermatophytosis
Authors: Collins J.-P. , Grappel Sarah F. , Blank F.
Published: October 2009

Fluorescein isothiocyanate conjugated rabbit antibodies to keratinase II were used to detect keratinase II and antibodies to keratinase II in sections of previously infected guinea pig skin. The presence of the enzyme or an antibody reaction to the enzyme was indicated by a perifollicular pattern of green fluorescence at the level of the external root sheath of the hair follicle. The results indicate that keratinase II is produced during infection with T. mentagrophytes var. granulosum. There is a local reaction to the enzyme in tissue which is also observed at the injection site following immunization with active keratinase II.
The Treatment of Tuberculosis of the Skin with a Combination of Rifampicin, Ethambutol and Isoniazid
Authors: Hulsebosch H.J. , Hendrikse J.C.M. , Ruiter D.
Published: October 2009

In 2 patients with tuberculosis cutis the combination of rifampicin, ethambutol and isoniazid had a good therapeutic result.
ATP-ase-Bestimmungen im menschlichen Spermaplasma
Authors: Brun F. , Sellei K. , Krebs A.
Published: October 2009

A quantitative photometric analysis of adenosine-triphosphatase in human seminal plasma is reported. In all the plasma investigated a decrease in the ATP-ase activity with time was found. The spermatograms of normal individuals displayed an ATP-ase activity which ranged within the limits of 19 IU and 6 IU after 15 and 60 minutes incubation with ATP respectively. Furthermore, limited sperm motility in most of the cases controlled appears to be correlated with a reduced ATP-ase activity.
Anatomic Localization of the Response to Ultraviolet Radiation in Human Skin
Authors: Stern W.K.
Published: October 2009

In an attempt to elucidate the site of injury from ultraviolet radiation (UVR) in human skin, histologic evaluation was performed after irradiation with the various ranges in the UV spectrum. Response to UVA (320–400 nm) irradiation produced changes varying from predominantly dermal (normal) to showing significant epidermal participation (abnormal). UVB (290–320 nm) irradiation produced both dermal and epidermal alterations, developing a moderate perivascular response in normal individuals and increasing to an intense vasculitis with marked epidermal changes in subjects with light associated diseases. UVC (200–290 nm) irradiation induced intense epidermal reactions and only a mild perivascular response. The common denominator in all instances is the apparent vascular injury.
Circulating Antibodies in Dermatophytosis
Authors: Grappel Sarah F. , Blank F. , Bishop C.T.
Published: October 2009

Antibodies to dermatophytes (M. audouinii, T. mentagrophytes var. granulosum and var. interdigitale, T. rubrum, and T. tonsurans) were detected in sera of patients with tinea capitis and tinea corporis by charcoal agglutination tests, immunodiffusion analysis, and complement fixation tests. In tinea capitis, these antibodies were not confined to patients with deep-seated, inflammatory infections. The zoophilic variety of T. mentagrophytes induced antibody formation more frequently than the anthropophilic variety in patients with tinea corporis. Precipitating and complement-fixing antibodies were often found in sera of patients with chronic T. rubrum infections. The agglutinating, precipitating, and complement-fixing antibodies persist for a limited period of time only; therefore, the time in the course of the infection at which blood is taken is of utmost importance for the study of circulating antibodies.
Unterschwellige Griseofulvindosen und Tierpathogenität der Dermatophyten
Authors: Fischer E.
Published: October 2009

Trichophyton gypseum asteroides (strain 830/67) was exposed for 12 month in vitro to a growth-non-inhibitory concentration of Griseofulvin. This treatment abolished its earlier pathogenecity for guinea pigs.
Fixed Drug Eruption to Oxyphenbutazone and Phenylbutazone
Authors: Nayyar K.C. , Pasricha J.S.
Published: October 2009

In the literature there is only one report of a fixed drug eruption due to oxyphenbutazone. We are reporting a patient whose fixed drug eruption was caused by oxyphenbutazone and who showed cross-sensitivity to phenylbutazone. There was no history of phenylbutazone having been administered to this patient earlier than the challenging test dose.
Beitrag zur quantitativen Bestimmung der Hautoberflächenlipide in der Praxis
Authors: Gloor M. , Schulz U. , Wieland G. , Wiegand I. , Friederich H.C.
Published: October 2009

The surface skin lipids were estimated quantitatively (casual level and replacement sum) in 33 subjects using Brun’s osmic acid test and in 14 subjects using Schäfer’s and Kuhn-Bussius’s opaque glass test. Gravimetric estimation of surface lipids were also carried out on symmetrical areas of the upper back using Honsig’s method. Thin layer chromatography was used to analyse the composition of the surface lipids. The osmic acid test was found to be superior to the opaque glass test. The composition of the skin lipids had no significant effect upon either method.
Xanthomatosen als Symptom von hyperlipidämischen Stoffwechselstörungen
Authors: Rufli T. , Stähelin H.
Published: October 2009

Three patients with different types of xanthomata and hyperlipoproteinaemia are described. One patient had eruptive xanthomata with a Fredrickson Type V hyperlipaemia, the second had tuberose xanthomata and Type III hyperlipaemia, while the third had eruptive, tuberose and tendon sheath xanthomata as well as flat xanthomata of palms without continuous evidence of hyperlipaemia and with impaired glucose tolerance. This patient had shown at times features of Fredrickson Type III hyperlipaemia. The different types of cutaneous xanthomata did not correlate with specific hyperlipaemias. Patients with hyperlipaemia and xanthomatosis appear to be more prone to develop occlusive vascular disease than those without skin lesions. Treatment with diet and serum lipid lowering drugs (nicotinic acid derivatives, Clofibrate, Cholestyramine and thyroid preparations) is discussed.