bluuebunny/crossref_metadata_2025 huggingface dataset:
Public-private partnership as an institution contributing to the integration of the economy of the Donetsk People's Republic into the economy of the Russian Federation: methodological aspect
Authors: Dmytrychenko Lilia I. , Chausovsky Alexander M. , Kanapukhin Pavel A.
Published: May 2024

Subject. With the entry of the Donetsk People's Republic (DPR) into the Russian Federation, it has become highly important to study the mechanisms of interaction and interpenetration of the two economies contributing to the formation of a single state. To implement this task, it is of paramount importance to adjust institutions, including the institution of public-private partnership (PPP). Objectives. To study the system of relations of public-private partnership and to find a model of public-private partnership which will fit the current state of the production forces in the DPR and contribute to the corresponding integration process. Methodology. The core principles of economic theory that address issues related to public-private partnership, the development of PPP relations, its forms, and models serve as the theoretical and methodological foundation of this study. The study is based on the dialectical method, which made it possible to identify inconsistencies within the public-private partnership system and suggest solutions to resolve them. This will ensure the integration of the DPR economy into the economy of the Russian Federation. The results of the study were substantiated by means of the retrospective analysis of the practice of public-private partnership relations in the Russian Federation, the DPR, and in foreign countries. Such analysis allowed validating the most effective mechanisms and models of PPP appropriate for the current circumstances in the DPR and the Russian Federation, encompassing the context of the special military operation. Results and discussion. As a result of the study, it was concluded that there are different methodological approaches to defining PPP. Scientists and practitioners tend to use a pragmatic approach and characterise PPP in the context of specific projects, which allows them to implement its specific models and mechanisms. On the other hand, a lack of thorough analysis of socio-economic relations within PPPs makes it difficult to search for an effective model of relations between the state and business. Therefore, the authors studied the subject within a socio-economic approach. This made it possible to develop a concept of public-private partnership relations which will fit the current circumstances, challenges, and threats (in which the economy of the DPR is functioning) and contribute to the integration of the economy of the DPR into the economy of the Russian Federation.
Self-Efficacy (SE) and Motivation of the Indonesian Teacher Educator Authors (TEAs) in Writing Articles for Publication: The Bloom Digital Taxonomy (BDT) Perspective
Authors: Turmudi Dedi , Dacholfany Muhammad Ihsan , Rasyidah Ummi
Published: May 2024

Background: Writing articles is inevitable for Teacher Educator Authors (TEAs) at the university level, and many studies reported writing articles for publication. However, self-efficacy (SE) and motivation in writing scientific articles by higher education teachers remained unexplored compared to the Bloom Digital Taxonomy (BDT).
Purpose: This study explored self-efficacy (SE) as well as intrinsic and extrinsic motivation (IM & EM) in writing articles for publication by Teacher Educator Authors (TEAs) in the light of the Bloom Digital Taxonomy (BDT). Furthermore, it measured how prior empirical evidence and current findings are presented in the Bloom Digital Taxonomy (BDT).
Method: The design used qualitative descriptive content data from an ethnographic study, and 21 Teacher Educator Authors (TEAs) of English in Indonesia with specific characteristics were purposively selected. The participants constituted state and private universities in Java, Sumatra, Borneo, and Celebes. Data were collected through questionnaire, in-depth interviews, and electronic observation. The participants were then requested to complete a Google Form, and directly interviewed electronically and physically. The questionnaire data were subsequently addressed in the in-depth interview. This study utilised the Criteria Content Analysis (CCA) method and exploratory-provisional coding to analyse the transcription data.   
Results: The results showed that self-efficacy (SE) features were mainly related to profession, self-development, and attributes of Teacher Educator Authors (TEAs). Furthermore, self-esteem, expertise markers, and a way to learn dominated intrinsic motivation (IM), while appreciation, shaping expertise, and seeking dignity dominated the extrinsic. The findings were in the high order of affective skills (HOAs) with valuing (A3) and internalising (A5). The study had practical implications that writing for scholarly publications should inevitably be part of the curriculum in higher education, and grants should increase to maintain the internalisation of Teacher Educator Authors (TEAs) in producing articles. In addition, the results contributed to the theoretical implication that HOAs, valuing, and internalising dominated roles in creating quality articles at any level.
Tiyatronun Rönesansı: Pandemi Döneminde Dijitalleşme ve Britanya Tiyatrosu
Authors: Şentürk Tatar Gamze
Published: May 2024

2019 yılında ortaya çıkıp dünyayı etkisi altına alan ve insanları evlerine hapseden pandemi süreci, tiyatro başta olmak üzere sahne sanatları üzerinde benzersiz bir etki yaratarak sahneyi bir dönüşüme uğratmıştır. Bu süreçte sahne sanatları alanında gelişen yeni duruma uygun olarak önlemler alınmaya çalışılmış ve sahne adeta yeniden şekillenmeye başlamıştır. Tiyatroda köklü değişikliklerin olduğu bu dönemde Britanya tiyatrosu da önerdiği yenilikçi ve deneysel uygulamalarla pandemi sürecini yönetmeye çalışmıştır. Kuşkusuz bu noktada teknolojinin sunduğu katkı göz ardı edilemez. Pandemi sürecinde dijitalleşen tiyatro, seyircisine yeni deneyimler yaşatmıştır. Sanatın evrensel gücünün bir kez daha anlaşıldığı bu süreçte teknoloji, biçim, içerik ve uygulama açısından tiyatroyu destekleyici bir unsur olarak ortaya çıkmıştır. Seyircisini oyunla buluşturan ve yenilikçi biçimlerin kullanılmasına büyük olanaklar tanıyan teknolojinin tiyatroda bir dönüşüm yaratması söz konusu olmuştur ve adeta tiyatroda bir rönesans yaşanmıştır. Bu çalışma, Britanya tiyatrosunun pandemi sürecini teknolojinin verdiği imkânlarla nasıl aştığını ortaya koymayı ve pandemi sürecinde tiyatro-teknoloji etkileşimini açığa çıkararak teknoloji çağında tiyatro endüstrisinin geleceğini tartışmayı amaçlamaktadır.
Generation of stable LysoTag expressing cell lines and LysoTag immunoprecipitation of lysosomes v1
Authors: Saarela Daniel
Published: May 2024

Molecular homeostasis in cells is regulated in part by protein degradation, which is facilitated by the proteasome and lysosomal proteolysis. Lysosomes are membrane bound organelles involved in the turnover of proteins, metabolites and lipids. Recent literature implicates lysosomal dysfunction to be a feature of many a disease, including neurodegenerative diseases. Focused investigation of lysosomal content (proteome/lipidome/metabolome) in disease states could lead to the discovery of novel therapeutics and disease mechanisms. Here we describe how to produce stable LysoTag expressing cell lines and how to perform rapid isolation of lysosomes in cultured cells with immunoprecipitation of the LysoTag using HA-coupled magnetic beads. The immunoprecipitation protocol is very fast, less than 15min from start of the incubation with the beads. The protocol can be used to immunoprecipitate lysosomes from commonly cultured cells such as mouse embryonic fibroblast, HEK293 and A549 cells expressing the LysoTag.
Contribution to the study of an eco-sand concrete containing recycled sands from waste granite and recycled clinker
Authors:   Department of Civil Engineering, 20 August 1955 University, LMGHU Laboratory, Rezaiguia Nouha , Hebhoub Houria ,   Department of Civil Engineering, 20 August 1955 University, LMGHU Laboratory, Kherraf Leila ,   Department of Civil Engineering, 20 August 1955 University, LMGHU Laboratory, Benhalilou Mohammed Ichem ,   TCT; University Batna 2
Published: May 2024

The reuse of waste materials, particularly granite and undercooked or overcooked clinker, in sand concrete formulation is the focus of this study aimed at conserving natural resources and protecting the environment within the framework of sustainable development. To achieve this objective, we replaced ordinary sand with recycled sands in the sand concrete volume. Specifically, we incorporated granite waste (GS) and recycled clinker (CS) at rates of 20 and 40%. Subsequently, we conducted a series of evaluations on the different formulations. These evaluations included fresh state properties such as density, workability, and air content, as well as mechanical properties like compressive strength, flexural strength, rebound hammer, ultrasonic pulse velocity, modulus of elasticity, and X-ray diffraction (XRD). Additionally, we analyzed durability parameters such as water absorption, dimensional variation, freeze-thaw resistance, acid attacks, and chloride penetration on hardened concrete. We compared these results with reference samples and considered potential correlations among the different parameters. The results obtained showed improvements in workability, hardness, and homogeneity with enhancements in microstructure, with the best results obtained from SCC compared to the control concrete and SCG. The results of mechanical properties demonstrated that concretes containing recycled clinker sand are more resistant in compression and flexural strength compared to SC0 and SCG, with maximum strengths observed in concrete containing 40% recycled clinker at ages 7, 28, and 90 days. Durability parameters were acceptable with slight reductions in ultrasonic pulse velocity and modulus of elasticity after freeze-thaw cycles. A good correlation was observed among the various parameters.
Estructura interna de la escala de estrés percibido (PSS) en personal de medicina y enfermería del Perú: un análisis exploratorio de grafos
Authors:   Universidad Privada del Norte, Cajamarca, Sánchez-Villena Andy Rick , de La Fuente-Figuerola Valeria ,   Centro de Estudios Familiares, Cajamarca
Published: May 2024

Introducción: la escala de estrés percibido (PSS), en su versión de 14 (PSS-14) y 10 (PSS-10) ítems, es un instrumento ampliamente utilizado. Sin embargo, ha sido poco estudiada en personal de medicina y enfermería y se ha reportado variedad de estructuras factoriales. Objetivo: examinar la estructura interna de la PSS en personal de medicina y enfermería del Perú mediante análisis exploratorio de grafos y análisis factorial confirmatorio. Materiales y métodos: la muestra se conformó por 2848 enfermeros y 2219 médicos, quienes participaron de ENSUSALUD del Ministerio de Salud de Perú en 2015 y se les administró la PSS-14 y PSS-10. El análisis se realizó con el paquete EGAnet y lavaan en R. Resultados: la PSS-14 formaba 2 dimensiones en personal de medicina y 3 dimensiones en el de enfermería, pero los ítems 12 y 13 mostraron poca solidez en este último grupo. El reanálisis, luego de retirar dichos reactivos, indicó que la versión de 12 ítems es plausible en enfermeros. Además, la PSS-10 mostró una estructura sólida con bidimensionalidad en ambos grupos. El análisis factorial confirmatorio encontró que los modelos bidimensionales tuvieron buen ajuste, además de tener confiabilidad y consistencia adecuadas. Conclusiones: la PSS es un instrumento útil para medir el estrés en personal de medicina y enfermería. Sin embargo, la PSS-10 es más adecuada; mientras que en la PSS-14 deben omitirse los ítems 12 y 13. Ambas versiones son bidimensionales, tanto para médicos como enfermeros.
A MODEL OF TRANSFORMATION OF A CHILD'S TRAUMATIC EXPERIENCES HIBUKI THERAPY METHOD
Authors:   Institution of Higher Education University of Educational Management, Kyiv, Ukraine, SHARON-MAKSIMOV Dafna
Published: May 2024

Background. The article is devoted to the description of the model of transformation of a child's traumatic experiences, which is part of the concept of Hibuki therapy, which is being actively implemented in Ukraine now by Israeli and Ukrainian psychologists. Methods. Modeling of a constructed ideal object-based on the identification of relationships between variables for the purpose of further verification for solving applied problems in the field of psychotherapy for children's trauma. Results. The presented model is a methodologically justified system that reflects the structural and functional connections of the recovery of the psyche of children of primary school age under the influence of therapeutic interventions with the help of a doll – a dog (Hibuki). It is assumed that children project their feelings and anxieties onto the toy object, identifying with these feelings and regulating emotions while caring for the Hibuki. The model reflects four levels of a child's mental functioning, which are the main "targets" of interventions in Hibuki therapy: emotional, cognitive, behavioral, physical. The spheres of traumatic experiences of younger schoolchildren are described, which meet certain criteria and expected results. Cognitive – reflective sphere. Criterion: awareness and understanding. Expected result: overcoming traumatic memories of past events. Emotional – affective sphere. Criterion: empathy and optimism. Expected result: stabilization of psycho-emotional state. Motivational and behavioral sphere. Criterion: attitude and effectiveness. Expected result: the ability to receive and provide support, establishing contacts and interactions. Physical and somatic sphere. Criterion: restoration of the body's functional capabilities. Expected result: recovery of physical activity. Conclusions. It is assumed that the complexity of the psychotherapeutic influence on various spheres of the child's psyche starts the process of personality dissociation, leads to the transformation of traumatic experiences, which are gradually integrated into the general picture of life.
Adaptation of a Russian Version of the Perceived Choice and Awareness of Self Scale (PCASS)
Authors: Kostromina S.N. , Molodtsova G.I. , Zinovieva E.V. , Odintsova M.M. , Filatova A.F.
Published: May 2024

To date, the issue of expanding the arsenal of adapted foreign tools (or creating their own) for assessing the level of self-determination of personality remains quite relevant. For this reason, the objective of the present study was to adaptation on the Russian-language sample of the modern version of the Self-Determination Scale by K. Sheldon and co-authors, in an updated version called the Perceived Choice and Awareness of Self Scale. Methods. The scale was translated with subsequent questioning of 588 respondents (residents of Russia, students of St. Petersburg educational institutions), including 325 women and 263 men (mean age - 20,5 ± 2,39, Mo = 21). Results. When assessing the psychometric properties of the Russian-language version of the adaptable questionnaire, significant results were obtained, indicating the reproducibility of the number and structure of the factors that form the two subscales of the original methodology. Also, psychometric indicators confirm the reliability, internal consistency, structural and constructive validity of the Russian version of the methodology. In addition, according to our study, the questionnaire is characterized by high differentiating ability and diagnostic sensitivity: significant gender differences were found in the Russian-speaking sample in terms of perceived choice and self-awareness. Conclusions. According to the results obtained, the adapted version of the questionnaire has good psychometric characteristics and can be used as a qualitative research tool.
Development and Analysis of Psychometric Properties of a New Russian Version of the Adverse Childhood Experience — International Questionnaire (ACE-IQ)
Authors: Kibitov A.A. , Trusova A.V. , Vyshinsky K.V. , Mazo G.E. , Kibitov A.|O.
Published: May 2024

Background. Adverse childhood experiences (ACE) is one of the most important risk factors for mental and somatic disorders and needs to be considered and evaluated in clinical and research practice. The aim of this study was to develop, adapt and validate the new Russian version of ACE-IQ. Methods. A total of 123 people (88 women, Me = 25 years) were included, of which about a half (n = 68) of the sample were patients with depression, the rest of the participants had no psychiatric diagnoses based on the results of the diagnostic interview. Results. ACE-IQ showed good reliability and internal consistency (Cronbach's alpha = 0.801). A six–factor structure of the questionnaire was identified («Sexual abuse», «Family violence», «Violence outside the family», «Mental disorders and substance abuse in the family», «Dysfunctional family factors», «Social Cataclysms»). Conclusions. We developed, adapted and validated the new Russian–language version of the ACE-IQ, retaining the structure and semantic equivalence of the original version of the questionnaire. Although confirmation of factor structure in other samples is needed, our data allows to recommend the new Russian version of the ACE-IQ for use in clinical and research practice.
Profile of Notifications of Deaths Due to Acute Myocardial Infarction in the I GERES Municipalities of Pernambuco, 2018-2021
Authors: Silva Matheus Vinicius Barbosa da , Araujo Gustavo Baroni , Neto Augusto Cesar Barreto
Published: May 2024

Abstract
In Brazil and around the world, cardiovascular diseases are responsible for thousands of deaths every year. Among these, those related to ischemic heart disease stand out. From this perspective, to assist in the development of effective and timely health strategies and policies, this study aimed to analyze deaths from Acute Myocardial Infarction (AMI) reported in municipalities belonging to the I Regional Health Management (GERES) of Pernambuco in the years 2018 to 2021. This is a retrospective ecological study, carried out using data from the Mortality Information System. The variables used to describe deaths from AMI were: municipality of coverage, sex, age, color/race, education, marital status and place of death. The results showed a reduction in deaths due to heart attacks in the municipalities and years investigated. The variables studied showed a statistically significant association with the rates of deaths from AMI. The predominant profile of deaths from heart attacks was among residents of the reef, male, mixed race, with one to three years of education, aged 75 and over and married. This study makes important contributions by describing the profile of deaths due to AMI in the I GERES municipalities of Pernambuco and can help guide public health strategies.
Keywords: Acute Myocardial Infarction. Mortality. Public Health.
Resumo
No Brasil e no Mundo, as doenças cardiovasculares são responsáveis por milhares de mortes todos os anos. Entre tais, destacam-se aqueles relacionados à doença isquêmica do coração. Nesta perspectiva, para auxiliar na elaboração de estratégias e políticas de saúde eficazes e oportunas, este estudo teve como objetivo analisar as mortes por Infarto Agudo do Miocárdio notificadas nos municípios pertencentes à I Gerência Regional de Saúde (GERES) de Pernambuco nos anos de 2018 a 2021. Trata-se de um estudo ecológico retrospectivo, realizado através de dados do Sistema de Informação de Mortalidade. A variáveis utilizadas para a descrição das mortes por IAM foram: município de abrangência, sexo, idade, cor/raça, escolaridade, estado civil e local de ocorrência do óbito. Os resultados mostraram redução dos óbitos por Infarto nos municípios e anos investigados. As variáveis estudadas apresentaram associação estatisticamente significativa com as taxas de mortes por IAM. O perfil predominante das mortes por infarto foi entre os residentes do recife, sexo masculino, pardos, escolaridade de um a três anos, com faixa etária de 75 anos e mais e com estado civil casado. Este estudo traz contribuições importantes ao descrever o perfil dos óbitos por IAM nos municípios da I GERES de Pernambuco, podendo auxiliar no direcionamento de estratégias em saúde pública.
Palavras-chave: Infarto Agudo do Miocárdio. Mortalidade. Saúde Pública.
Transforming Health Care Delivery: Innovations in Payment Models for Interprofessional Team-Based Care
Authors: Khalili Hossein
Published: May 2024

By examining the strengths, limitations, and implications of different payment models we seek to inform policymakers, practitioners, and educators on the path toward patient-cen­tered, efficient, and sustainable primary health care deliv­ery. Health care payment model reform should be viewed as an investment in future health asset capacity and equity production rather than an immediate return on investment for short-term health care cost reduction.
Oil Dependency: Impact on the economy of Ecuador
Authors: Bernal Yamuca Jorge Luis , Molina Argudo Fernando Antonio , Maldonado Castro Ángel Boris , Vera Valdiviezo Nivaldo Apolonides , Zamora Rizzo Alex Adrián , Sánchez Toala Ximena Nicole
Published: May 2024

Oil is Ecuador's main export product and its financial income an important part of the General State Budget. Being Ecuador a country dependent on crude oil is the reason why this investigation is carried out. For this purpose, an investigation with a quantitative approach was used, with a descriptive and explanatory scope strengthened in the Solow model, for which an econometric model with time series data was estimated using the Ordinary Least Squares (OLS) method. The results show that oil barrel exports have a positive effect on economic growth. Likewise, it is concluded that oil imports, the price of oil, will have a greater dynamism in economic growth, since there is a strong causality with the aforementioned variables.
Hotel demand forecasting models and methods using artificial intelligence: A systematic literature review
Authors:   Universidade do Algarve, Escola Superior de Gestão, Hotelaria e Turismo, Research Centre for Tourism, Sustainability and Well-Being (CinTurs), Portugal, Henriques Henrique , Nobre Pereira Luis ,   Universidade do Algarve, Escola Superior de Gestão, Hotelaria e Turismo, Research Centre for Tourism, Sustainability and Well-Being (CinTurs), Portugal
Published: May 2024

This systematic literature review (SLR) explores current state-of-the-art artificial intelligence (AI) methods for forecasting hotel demand. Since revenue management (RM) is crucial for business success in the hotel industry, this study aims to identify state-of-the-art effective AI-based solutions for hotel demand forecasting, including machine learning (ML), deep learning (DP), and artificial neural networks (ANNs). The study conducted an SLR using the PRISMA model and identified 20 papers indexed in Scopus and the Web of Science. It addresses the gaps in the literature on AI-based demand forecasting, highlighting the need for clarity in model specification, understanding the impact of AI on pricing accuracy and financial performance, and the challenges of available data quality and computational expertise. The review concludes that AI technology can significantly improve forecasting accuracy and empower data-driven decisions in hotel management. Additionally, this study discusses the limitations of AI-based demand forecasting, such as the need for high-quality data. It also suggests future research directions for further enhancing AI forecasting techniques in the hospitality industry.
Dynamics of the content of reactive oxygen species and the state of the glutathione system in the oral cavity during subchronic intoxication wuth the fungicide thiram and its antioxidant correction
Authors: Korolev V.A. , Felker E.V. , Yachmeneva L.A. , Babkina L.A. , Azarova Y.A. , Churilin M.I. , Milova A.I.
Published: May 2024

Thiram is a dithiocarbamate derivative, which is used as a fungicide for seed dressing and spraying during the vegetation period of plants, and also as an active vulcanization accelerator in the production of rubber-based rubber products. In this study the content of reactive oxygen species (ROS) and the state of the glutathione system have been investigated in the oral fluid and gum tissues of adult male Wistar rats treated with thiram for 28 days during its administration with food at a dose of 1/50 LD50. Thiram induced formation of ROS in the oral cavity; this was accompanied by an imbalance in the ratio of reduced and oxidized forms of glutathione due to a decrease in glutathione and an increase in its oxidized form as compared to the control. Thiram administration caused an increase in the activity of glutathione-dependent enzymes (glutathione peroxidase, glutathione transferase, and glutathione reductase). However, the time-course of enzyme activation in the gum tissues and oral fluid varied in dependence on the time of exposure to thiram. In the oral fluid of thiram-treated rats changes in the antioxidant glutathione system appeared earlier. The standard diet did not allow the glutathione pool to be fully restored to physiological levels after cessation of thiram intake. The use of exogenous antioxidants resviratrol and an Echinacea purpurea extract led to the restoration of redox homeostasis in the oral cavity.
Assessment of platelet functional activity in healthy individuals and patients receiving antiplatelet therapy. Possible inconsistencies between aggregation and flow cytometry tests
Authors: Bodrova V.V. , Shustova O.N. , Golubeva N.V. , Alieva A.K. , Vlodzyanovsky V.V. , Pevzner D.V. , Mazurov A.V.
Published: May 2024

Platelet functional activity was assessed in healthy volunteers (HV, n=92), patients with stable angina pectoris (SA, n=42) and acute coronary syndrome (ACS, n=73), treated with acetylsalicylic acid (ASA) + clopidogrel and ASA + ticagrelor, respectively. In all HV and patients we have compared parameters of platelet aggregation (maximum light transmission and velocity, Tmax and Vmax) and parameters, characterizing exposure of platelet activation markers, evaluated by flow cytometry. HV platelets were activated by 10 μM, 1 μM TRAP, and 20 μM, 5 μM, 2.5 μM ADP; patient platelets were activated by 10 μM TRAP and by 20 μM and 5 μM ADP. Strong and significant correlations between the aggregation and flow cytometry parameters (the r correlation coefficient from 0.4 up to >0.6) most frequently were registered in HV platelet during activation by 1 μM TRAP and in SA patients during platelet activation by 20 μM and 5 μM ADP. However, in many other cases these correlations were rather weak (r < 0.3) and sometimes statistically insignificant. In HV the differences in PAC-1 binding parameters between platelets activated by 10 μM TRAP (the strongest agonist) and all ADP concentrations were negligible (≤ 10%), while CD62P binding (at all ADP concentrations) and LTA parameters for (5 μM and 2.5 μM ADP) were significantly lower (by 40–60%). Antiplatelet therapy in patients decreased all parameters as compared to HV, but to varying extents. For 10 μM TRAP the MFI index for PAC-1 binding (40–50% decrease) and for both ADP concentrations the Tmax values (60–85% decrease) appeared to be the most sensitive in comparison with the other parameters that decreased to a lesser extent. The data obtained indicate a possibility of inconsistency between different LTA and flow cytometry parameters in assessing platelet activity and efficacy of antiplatelet drugs.
Determination of the levels and possible associations of alpha2-macroglobulin with autoantibodies in the serum of patients with various forms of autoimmune thyroiditis
Authors: Rahimova R.R. , Efendiyev A.M. , Shahverdiyeva I.J. , Dashdamirova G.S. , Kerimova I.A.
Published: May 2024

Antibodies to thyroid peroxidase (AB-TPO), antibodies to thyroglobulin (AB-TG), and the content of α2-macroglobulin (α2-MG) have been studied in serum samples of patients with autoimmune thyroiditis (AIT). All the patients were divided into 3 groups depending on age: 25–35, 36–50, 51–65 years. We found a significant change in the thyroid panel parameters in AIT, but without significant changes in the average concentration of α2-MG in the age groups of patients. This may be due to the accumulation and retention of complexes of defective forms of α2-MG in the circulation associated with their decreased ability to bind to receptors.
IDENTIFICATION OF MOBILITY STRATEGIES FOR SMALL AND URBANIZED BRAZILIAN MUNICIPALITIES
Authors: Herszon Meira Leonardo , De Oliveira Leise Kelli , Pires Dannúbia Ribeiro
Published: May 2024

Due to intense urbanization and inadequate planning, various mobility problems have emerged in small Brazilian municipalities. To reverse this scenario, it is necessary to adopt sustainable mobility policies. Thus, this article aims to identify mobility strategies for small and urbanized Brazilian municipalities. Firstly, based on the literature, twenty strategies were identified. Then, experts and managers evaluated these strategies to identify the most suitable ones for small municipalities. Next, the data was analyzed to measure the reliability of the responses, the correlation, and the ranking of the strategies. Finally, the most appropriate strategies were identified using Categorical Principal Component Analysis. The results indicated that the most relevant strategies to be implemented in small Brazilian municipalities are related to policy issues, promoting active transportation, and encouraging public transportation. The findings can improve public policies and transportation planning, with implications for quality of life and sustainable development in small Brazilian municipalities.
Papillary thyroid cancer and its gene polymorphism; A molecular mechanistic perspective
Authors: Sheikh Abid Ali , Makhdoomi Mudassir Jan , Rather Abid Hussain , Lone Tasleem Arif , Syed Nisar Ahmad
Published: May 2024

Thyroid cancer stands as the predominant malignancy within the endocrine system, comprising about 1% of newly identified cancer instances. Papillary Thyroid Cancer (PTC) is the predominant form of thyroid cancer, representing 80% or more of thyroid malignancies. Thyroid carcinoma harbours assorted genetic alterations which are highly prevalent, several of these characteristics are unique to this form of cancer. The conventional oncogenic genetic modifications frequently observed in thyroid carcinoma encompass RAS mutations RET/PTC rearrangements and PAX8-peroxisome proliferator-activated receptor g (PPARg) fusion oncogene. The lately discovered activating mutation in BRAF (the gene for the B-type RAF kinase, BRAF) the most widespread genetic modification in thyroid cancer (30-83%). RKIP (RAF kinase inhibitory protein) had formerly been delineated as a phospholipid binding protein. Mammalian RKIP/PEBP differs from other identified proteins and its role is still being clarified. RKIP over-expression can inhibit MEK interaction with RAF-1 and B-RAF. It plays a role in thyroid cancer progression and lymph node metastasis. So, elucidating mutational profile and protein expression of above cell signalling molecules will be very useful in determining a proper therapeutic target for anti-cancer molecules. Given that tumors often possess numerous genetic and cell signalling abnormalities, thus inhibiting a single signalling pathway is often therapeutically inefficacious, more success could be foreseen with agents directed against multiple cellular pathways.

By determining the genetic profile and protein expression of mentioned MAP Kinase pathway molecules new targets can be identified for chemotherapic drugs and novel strategies will be charted out to make modifications in the map kinase pathway with the aim to stop the occurrence and distant metastasis of thyroid cancer.
Investigation of effect of ellagic acid on premature ovarian insufficiency
Authors: Sarode Vinay Vishnudas , Gautam Sadhna P.
Published: May 2024

One common medical condition affecting the reproductive system in older women is premature ovarian failure (POF). POF can result from radiation therapy, chemotherapy, immune system problems, infection, inflammation, and genetic mutation.

The current study examined the effect of Ellagic acid on Premature Ovarian Insufficiency.

The study utilized, 8-12 months old 150 ± 20 gm, 42 female wistar rats. For the induction of Premature Ovarian Insufficiency, Tripterygium Glycoside (TG) was administered at a dosage of 50 mg/ml dissolved in water for injection once daily. Clomiphene Citrate, 1 mg/kg was administered orally once daily for 21 days. Ellagic acid was given orally once daily at concentration of 10 mg/kg, 20 mg/kg, 30 mg/kg. The statistic of the data was determined by using ANOVA test.

The results showed that effect of Ellagic acid on premature ovarian insufficiency as evidenced by decreased levels of cholesterol, triglycerides, follicle stimulating hormone and Luteinizing hormone and increased levels of estrogen.

According to the current study, female wistar rats with Tripterygium Glycoside induced Premature Ovarian Insufficiency can benefit from treatment with an Ellagic acid.
Cost-effective analysis of enalapril, amlodipine, and enalapril plus amlodipine combination in newly diagnosed patients of hypertension: A pharmacoeconomic comparison of the antihypertensive efficacy of drugs
Authors: Katariya Kajalben Jashubhai , Gosai Tushar , Parmar Akshay Hasmukhbhai
Published: May 2024

Hypertension (HTN) is a chronic condition with severe complications, so early detection and effective management are essential to prevent cardiovascular events and reduce the associated economic burden. This study aims to compare the cost-effectiveness of enalapril, amlodipine, and their combination in terms of blood pressure reduction, considering overall efficacy and economic implications.

A prospective, observational cost-effectiveness analysis was conducted in 150 newly diagnosed hypertensive patients who were prescribed either enalapril (5 mg), amlodipine (5 mg), or enalapril plus amlodipine (2.5 mg each). The primary outcome was the difference in systolic and diastolic blood pressure between baseline and follow-up, as well as the evaluation of overall efficacy and cost. Based on the data, statistical analysis was carried out using ANOVA and post hoc Tukey tests for drug efficacy, and cost-effectiveness was compared using MS Excel.

After 30 days, all treatments significantly reduced systolic and diastolic blood pressure (p = 0.0001). The combination therapy with a lower dose showed superior efficacy in blood pressure reduction and was most cost-effective, requiring less expense for a 1 mmHg reduction in blood pressure compared to individual drugs with a higher dose. Quality of life assessment favored low-dose combination therapy, with fewer reported adverse effects.

The combinationof amlodipine and enalapril at a lower dose demonstrated superior cost-effectiveness, efficacy in blood pressure reduction, and a favorable impact on patients' quality of life compared to individual drugs at a higher dose. This suggests that combination therapy may be a preferred option in the management of hypertension, emphasizing the importance of considering both clinical and economic factors in treatment decisions.
Revista Integración & Comercio No. 49: Año 28, Mayo 2024: El giro verde: la nueva agenda de comercio de América Latina y el Caribe
Authors: Ramos María Priscila , Rozemberg Ricardo , Schwartz M. Marco , Kern F. Werther , Marchant S. Ricardo , Mango Francisco , Calvo Jimena , Arias Mahiques Victoria , Villafañe María Fernanda , De la Vega Pablo , Park Leonardo , Sancisi Ángeles , Gutman Verónica , Fagundes Cezar Rodrigo , Camargo Juliana , Sun Yixian , Cabrini Silvina , Cristeche Estela , Amaro Ignacio Benito , Faverin Claudia , Gastaldi Laura , Pace Guerrero Ignacio , Olemberg Demián , Piperata Marcela , Recavarren Paulo , Said Andrés , Tieri María Paz , Vidal Ruy , Canepa Pérez Ileana M. , Meneses Requena Salvador , Dzul Caamal Ricardo , Martinez Cruz Adan , De Angelis Jesica , Michalczewsky Kathia , Sternberg Sofía
Published: May 2024

Esta edición número 49 de la revista tiene como objetivo abordar los nuevos desafíos y oportunidades de la agenda ambiental y sus implicancias para el comercio internacional de los países de América Latina y el Caribe. A través de seis artículos, se aporta evidencia empírica y conceptual innovadora sobre temas clave para impulsar esta agenda a nivel regional, con la intención de generar sugerencias y recomendaciones de políticas para los sectores público y privado en los países de América Latina y el Caribe. De los seis artículos que componen la publicación, cinco de ellos fueron elaborados por los ganadores de un llamado a investigación en colaboración con el Instituto Interdisciplinario de Economía Política de Buenos Aires (IIEP) de la Facultad de Ciencias Económicas de la Universidad de Buenos Aires (UBA). En tanto, un sexto artículo fue producido por el equipo del Instituto para la Integración de América Latina y el Caribe (INTAL) del Sector de Integración y Comercio (INT) del Banco Interamericano de Desarrollo (BID). Desde el BID INTAL creemos que el comercio internacional es un canal esencial para avanzar hacia un desarrollo verde, resiliente e inclusivo en los próximos años. Y puede contribuir a reducir los efectos del cambio climático y acompañar los esfuerzos de adaptación y mitigación.
Aprovechamiento de recursos turísticos de Perú para su puesta en valor: casos de estudio de Ayacucho
Authors: Mesías Changa Luis Alberto
Published: May 2024

El turismo es uno de los principales sectores con gran potencial de crecimiento en las economías andinas. Frente al desafío de llevar a cabo un proceso de transformación productiva, varios países de la Región Andina han señalado al turismo como un sector con gran potencial de desarrollo en la región. Hoy en día, este sector ha tenido solamente un rol limitado en estas economías, el cual se vio aún más reducido por la pandemia. Pese al rol limitado que ha tenido este sector, su potencial de crecimiento es importante, especialmente dado el gran capital natural y cultural que hace únicos a los países andinos. Construyendo sobre esta idea, este estudio explora cómo el sector turismo en Perú puede jugar un papel más prominente. Esta es una de seis notas que analizan esta cuestión para cada uno de los países de la Región Andina Bolivia, Colombia, Ecuador, Perú y Venezuela y para la región de manera agregada. Específicamente, se explora el estado del sector, el marco institucional relevante en el país, así como un estudio de caso de activos con potencial a desarrollar.
Electrical transport properties of Cu2ZnSnSe4 thin films for solar cells applications
Authors: Seña Neyder Jesús , Dussan Cuenca Anderson , Gordillo Guzmán Gerardo
Published: May 2024

In this work we study the electrical transport properties of Cu2ZuSnSe4 (CZTse) thin films. CZTSe thin films were prepared by PVD method; the parameters of deposition as substrate temperature (T,) and mass, (Mx), (Mx = ZnSe, Cu) were varied for a range wide. Conductivity and resistivity measurements as a function of temperature were obtained between 120 and 400 K. It was observed, that high-temperature range above room temperature (>300 K) the carrier transport is thermally activated, with a single activation energy that changes with the variation of T, and Mx. In the low-temperature range (<300 K)), variable range hopping (VRH) was established as a predominant electronic transport mechanism for all samples. Hoppmg parameters were obtained by Difíusinal model and percolation theory.
Grätzel type-solar cells sensitized with some Colombian's dyes
Authors: Perez Eduardo , Montalvo Kiara , Acuña María , Rada Tomás , Buchholz Florian
Published: May 2024

In the present work we want to show some progress related to the effects of two colombian's natural dyes in the sensitized solar cells (Grätzel type). The dyes used are achiote and blackberry, which are used to develop a photochemical process that mimics photosynthesis. The use of sensitizers in conjunction with nanocrystalline oxide semiconductor films (TiO2) permits to increase the absorption of sunlight. Raman spectroscopy technique has been used to characterize the achiote. They show that the samples have a strong fluorescence in the range between 640 and 800 nm, and this fluorescence is very sensitive to the laser power. After the construction of the solar cells, the efficiencies determined are around 0.13%, in the best of our cases.
Characterization of Cr/CrN nano multilayers obtained through reactive sputtering with different degrees of unbalance in the magnetron
Authors: Piratoba Morales Ulises , Olaya Flórez Jhon Jairo
Published: May 2024

Nanoscale hard coatings of bilayers of Cr/CrN were obtained and characterized through unbalanced magnetron sputtering (UBMS) in an atmosphere of Ar and Ar + N2 on silicon and hardened and tempered H13 steel, with a degree of unbalanced K0 between 0.87 and 1.37. The deposition parameters were as follows: a power of 160 watts, Ar and N2 flow rates of 9 and 3 sccm, and a substrate target distance of 5 cm. A Gen coa VT 100 magnetron with varying degrees of unbalance, obtained by displacing its central magnet, was used. The electrochemical behavior of these coatings was characterized using the technique of potentiodynamic anodic polarization. The coatings' microstructure and hardness were analyzed via X-ray diffraction (XRD) and nanoindentation tests; Cr, CrN, and Cr2N phases were obtained, with a hardness that increases with the degree of unbalance between 18.90 and 24.97 GPa.
Morphological, structural and magnetic characterization of black sanos of the Guajira- Colombia
Authors: Parra Sua Johana Patricia , Sjogreen Blanco Carlos Andrés , Alfonso Orjuela José Edgar , Landínez Téllez David Arsenio , Roa-Rojas Jairo
Published: May 2024

This article shows the morphological, structural and magnetic properties of the black sand on the surface soil obtained in the Guajira-Colombia. Morphological characterization of samples is performed by SEM. The compositional analysis of the compounds and elements was carried out through the XRF technique and by applying the Rietveld method to the X-ray diffraction data by quantifying the polycrystalline phases present in the sample such as ilmenite and magnetite. Magnetic characterization was performed by obtaining the hysteresis curve of magnetization as a function of applied fields at 300K temperature. Results evidence a ferromagnetic behavior of sample with magnetic parameters that permit to discuss the origin of magnetic character in the black sands. From heat treatments on air at different temperatures, the present magnetic phases are studied in order to determine the possibility obtaining of a single phase.
New report of decapod crustaceans from the Miocene of Iran
Authors: Garassino Alessandro , Pasini Giovanni , Ataabadi Majid Mirzaie , Hadi Mehdi , Parsazad Meraj , Nyborg Torrey , Vega Francisco J.
Published: May 2024

We report some brachyuran crabs from the late Miocene of Dar Pahn unit, Makran Province, Iran. The studied specimens have been assigned to Ixoides MacGilchrist, 1905, with I. miocenicus n. sp. (Leucosiidae Samouelle, 1819) and Persianus arcuatus n. gen., n. sp. (Portunidae Rafinesque, 1815). Ixoides miocenicus n. sp. represents the first fossil representative of the genus, enlarging its stratigraphic range to the Miocene. Persianus arcuatus n. gen., n. sp. represents the first report of a portunid crab from the Miocene of Iran. We also report an indeterminate majoid crab, representing the first report for the Majoidea from the Miocene of Iran. Finally, one portunid crab is compared with Persianus n. gen. based on some similar morphological characters.
An analysis of translanguaging practices in an Indonesian EFL classroom: teacher perception
Authors: Sakkir Geminastiti , Al Amir Fitrah , Atmowardoyo Haryanto , Weda Sukardi , Rosmayanti Vivit
Published: May 2024

This study aimed to find out a teacher’s perceptions about translanguaging. This study used a qualitative descriptive method, and data was collected through interviews. The interview process was conducted with a teacher from class IX.2 SMPN 4 Bulukumba. The findings showed that the teacher argued that translanguaging makes students understand the material more quickly, students are more active, and it creates a supportive learning environment. The teacher thought that translanguaging has a drawback, namely it limits the development of students' vocabulary. To ensure that the use of translanguaging did not interfere with the development of students’ English skills, the teacher tried to use English more often than Indonesian. The teacher also thought that translanguaging was one of the best ways to teach English. Based on the results of the research, it can be concluded that the implementation of translanguaging has a positive impact on the process of teaching and learning English in EFL classrooms.
Multilingual views of food service signage
Authors: Atabekova Anastasia
Published: May 2024

The paper considers the multilingual views of food services signage. The food ser-vice sign boards are selected as the research topic due to their sociocultural relevance: food is viewed as part of national cultural codes and international universals. The paper aims to determine the variants of multilingual names of food service companies (cafes, restaurants) and the attitude to the respective names' variants from the part of various categories of the population. The method-ology uses a mixed-method approach, combining theoretical analysis of the academic sources, empirical categorization of food signages, interviews of various catego-ries of respondents, and statistical processing of the respondents' data and their replies. The research results have made it possible to identify major trends in the language repertoire of food service signages, identify different groups of the re-spondents' population regarding their attitudes towards the linguistics repertoire of food service sign boards, and outline promising communicative practices in the field. The results can be used for linguists' training in the field of sociolinguis-tics for advertising specialists-to-be education regarding the potential and bound-aries of the multilingual landscape concerning its communicative, pragmatic, and ideological values. Moreover, the collected data can be used as a didactic back-ground for translators' training focusing on the translanguaging phenomenon.
Textual mediation for adult immigrants in initial teacher training
Authors: Peña-Acuña Beatriz , Cislowska Anna I.
Published: May 2024

Initial teacher trainees are preparing for multilingualism and multicultural work environments that present the challenge of mediating texts aimed at teaching adult immigrants in an additional language. The study aims to investigate the perceptions of university education students regarding textual mediation suitable for immigrant adults. Qualitative inquiry involves 130 university students through discussion groups after a textual mediation intervention. Results emphasize the impact of applied practice on skill perception and acquisition across educational levels and highlight the necessity of integrating practical experiences into teacher training.