bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGIC SPATIAL DEVELOPMENT OF MANAGEMENT IN THE SPHERE OF REGIONAL AGROINDUSTRIAL COMPLEX
Authors: Semkin А. G.
Published: May 2019

Improving the management system based on the strategic directions of the regional agricultural sector spatial development in the production distribution area plays a huge role in the management and agricultural production modernization. In the proposed methodological and practical approaches specific recommendations are given on the implementation of program activities for the development of the digital economy and perspective areas based on sound methods and forms that contribute to the spatial development of production and the economy in the sub-industry and rural areas. One of the ways to improve the management system of regional agriculture in the production field should be a strategic approach associated with the transformation of the economic relations of regional authorities and local self-governments with the agricultural business subjects on the basis of information and electronic relationships, where digital technologies the using becomes the main factor of growth of agricultural production competitiveness development. The digitalization development should occur in state authorities, it is necessary to build effective management structures for regional agro-industrial complex in the information space. The effectiveness of management systems when locating production in the agro-industrial complex, as in any other industry, depends on the level of digital technologies mastering and the share of expenditures on the country's digital economy in GDP. The managing processes of the spatial development of the location of the regional agricultural production should be built on the basis of creating new strategy forms: vertically-oriented ways and methods of interaction between the government and the agrarian business. But at the same time one of the main directions of development of these relations should be the effective interaction of municipalities and economic management representatives with the use of the advantages of territorial and sectoral division. The application of the digital economy elements in the regional agro-industrial complex based on the priority of management in locating agricultural production and building interdependent relations of economic and state management will contribute to economic growth and social development of agricultural producers and rural areas directly interacting with them.
Atuação do enfermeiro na área de incontinências: podemos fazer mais
Authors: Assis Gisela Maria
Published: May 2019

Quero convidá-lo à uma reflexão sobre a atuação da nossa estimada estomaterapia na área de incontinências. Ou, como prefiro me referir a ela, a área das disfunções miccionais e evacuatórias, compreendendo que as disfunções vão além da perda urinária ou fecal, contemplando também a retenção urinária e a constipação intestinal.
OPTIMASI SISTEM ANTRIAN PADA LAYANAN KESEHATAN MASYARAKAT MENGGUNAKAN PENDEKATAN SIMULASI
Authors: Findari Widya Setia , Nugroho Yohanes Anton
Published: May 2019

Abstract : The purpose of this study is to optimize service time in a community health center. The average number of patients visiting is 100 to 300 per day. In certain units there is a heavy queue of patients which increases service waiting times, including registration units, inspection units, and pharmaceutical units. The initial observation data on the existing system shows the waiting time for patient services is 2,7 hours. This fact shows that the time of patient service on the existing system needs to be optimized so that the waiting time can be accelerated. This study offers a solution to optimize the service queue system using a simulation approach. The DMAIC (Define, Measure, Analyze, Improve, Control) Six Sigma method is used as a basis for analyzing the waiting time for services from an existing system. The results of the analysis are used in the simulation test to obtain improvement factors using several scenarios. The best simulation results are obtained with the scenario of adding operators in all units. Optimizing the waiting time of patient services using the best scenario simulation approach is shown by the decrease in waiting time of the queue system by 1,05 hours or 38,9% faster than the existing system.Keywords: System Optimizing; Public Health; Queue; Simulation; DMAIC Six SigmaAbstrak : Tujuan penelitian ini adalah untuk mengoptimalkan waktu tunggu pelayanan di sebuah pusat kesehatan masyarakat (Puskesmas). Rata-rata jumlah pasien yang berkunjung adalah 100 hingga 300 per hari. Pada beberapa unit tertentu terjadi antrian pasien yang padat sehingga meningkatkan waktu tunggu pelayanan, antara lain unit pendaftaran, unit pemeriksaan, dan unit farmasi. Data pengamatan awal pada sistem yang ada menunjukkan waktu tunggu pelayanan pasien adalah 2,7 jam. Fakta ini menunjukkan bahwa waktu pelayanan pasien pada sistem yang ada perlu dioptimalkan agar waktu tunggu dapat dipercepat. Penelitian ini menawarkan solusi optimalisasi sistem antrian pelayanan dengan menggunakan pendekatan simulasi. Metode DMAIC (Define, Measure, Analyze, Improve, Control) Six Sigma digunakan sebagai dasar analisis waktu tunggu pelayanan dari sistem yang sudah ada. Hasil analisis digunakan pada uji simulasi untuk mendapatkan faktor perbaikan dengan menggunakan beberapa skenario. Hasil simulasi terbaik diperoleh dengan skenario penambahan operator di semua unit. Optimasi waktu tunggu pelayanan pasien dengan menggunakan pendekatan simulasi skenario terbaik ditunjukkan oleh penurunan waktu tunggu sistem antrian sebesar 1,05 jam atau 38,9% lebih cepat dari sistem yang sudah ada.Kata kunci: Optimasi Sistem, Layanan Kesehatan, Antrian, Simulasi, DMAIC Six Sigma
How curiosity enhances hippocampus-dependent memory: The Prediction-Appraisal-Curiosity-Exploration (PACE) Framework
Authors: Gruber Matthias , Ranganath Charan
Published: May 2019

Curiosity plays a fundamental role for learning and memory, but the neuralmechanisms that stimulate curiosity and its effect on memory are poorlyunderstood. Accumulating evidence suggests that curiosity states are related tomodulations in activity in the dopaminergic circuit, and that these modulationsimpact memory encoding and consolidation for both targets of curiosity andincidental information encountered during curiosity states. To account for thisevidence, we propose the Prediction, Appraisal, Curiosity, and Exploration(PACE) framework, which attempts to explain curiosity and memory in terms ofcognitive processes, neural circuits, behavior, and subjective experience. ThePACE framework generates testable predictions that can stimulate futureinvestigation of the mechanisms underlying curiosity-related memoryenhancements.
Chương trình máy tính Việt bayesvl chính thức xuất bản trên CRAN
Authors: University KHCN Phenika
Published: May 2019

Bài giới thiệu phần mềm Bayesvl được xuất bản chính thức trên CRAN của phòng Khoa học & Công nghệ, đăng tải trên: http://phenikaa-uni.edu.vn/chitiet/su-kien/phan-mem-viet-bayesvl-chinh-thuc-xuat-ban-tren-cran.
'Is there a connection between quantity and quality' in a scientific article?
Authors: Lobo Matheus Pereira
Published: May 2019

Aside from the title, abstract, keywords, and references, I guess we have just set a new world record for the shortest article, i.e., one word (two letters, actually). This is a serious nanoarticle, published in the Open Journal of Mathematics and Physics (OJMP). It poses a valid and important scientific question and address the solution by using methods of research, including the communication of the result in the format of an article, with title, author, affiliation, abstract, keywords, and references. The OJMP is an overlay open access journal, 100% free to read and to publish, mainly with the purpose to show that there are other ways of doing science beyond the traditional way.
On a Quest for Cultural Change - Surveying Research Data Management Practices at Delft University of Technology
Authors: Andrews Heather , Teperek Marta , van Dijck Jasper , Heijer Kees den , Eggermont Robbert , Plomp Esther , der Velden Yasemin Turkyilmaz-van , Kurapati Shalini
Published: May 2019

The Data Stewardship project is a new initiative from the Delft University of Technology (TU Delft) in the Netherlands. Its aim is to create mature working practices and policies regarding research data management across all TU Delft faculties. The novelty of this project relies on having a dedicated person, the so-called ‘Data Steward’, embedded in each faculty to approach research data management from a more discipline-specific perspective. It is within this framework that a research data management survey was carried out at the faculties that had a Data Steward in place by July 2018. The goal was to get an overview of the general data management practices, and use its results as a benchmark for the project. The total response rate was 11 to 37% depending on the faculty. Overall, the results show similar trends in all faculties, and indicate lack of awareness regarding different data management topics such as automatic data backups, data ownership, relevance of data management plans, awareness of FAIR data principles and usage of research data repositories. The results also show great interest towards data management, as more than ~80% of the respondents in each faculty claimed to be interested in data management training and wished to see the summary of survey results. Thus, the survey helped identified the topics the Data Stewardship project is currently focusing on, by carrying out awareness campaigns and providing training at both university and faculty levels.
Breaking the vise of hopelessness: Targeting its components, antecedents, and context
Authors: Marchetti Igor , Alloy Lauren B , Koster Ernst H. W.
Published: May 2019

Hopelessness is a painful state that is related to depression and suicide. In spite of its importance, only unsystematic efforts have been made to specifically target hopelessness in interventions, and no comprehensive review is currently available to guide future clinical studies. Hence, we first analyze the phenomenon of hopelessness, by highlighting its components (e.g., lack of positive expectations, blocked goal-directed processing, and helplessness), antecedents (e.g., inferential styles and future orientation), and contextual factors (e.g., loneliness and reduced social support). Then, we review the currently available interventions and manipulations that target these mechanisms, either directly or indirectly, and we highlight both their strengths and lacunae. Finally, we propose possible avenues to improve our clinical toolbox for breaking the vise of hopelessness.
Nonlinear numerical simulation of punching shear behaviour of reinforced concrete flat slabs with shear-heads
Authors: Bompa D.V. , Elghazouli A.Y.
Published: May 2019

This paper examines the structural response of reinforced concrete flat slabs, provided with fully-embedded shear-heads, through detailed three-dimensional nonlinear numerical simulations and parametric assessments using concrete damage plasticity models. Validations of the adopted nonlinear finite element procedures are carried out against experimental results from three test series. After gaining confidence in the ability of the numerical models to predict closely the full inelastic response and failure modes, numerical investigations are carried out in order to examine the influence of key material and geometric parameters. The results of these numerical assessments enable the identification of three modes of failure as a function of the interaction between the shear-head and surrounding concrete. Based on the findings, coupled with results from previous studies, analytical models are proposed for predicting the rotational response as well as the ultimate strength of such slab systems. Practical recommendations are also provided for the design of shear-heads in RC slabs, including the embedment length and section size. The analytical expressions proposed in this paper, based on a wide-ranging parametric assessment, are shown to offer a more reliable design approach in comparison with existing methods for all types of shear-heads, and are suitable for direct practical application.
Restorasi Sosial Untuk Indonesia Maju dan Bermartabat
Authors: Yunaz Haswan
Published: May 2019

Bersamaan dengan kemajuan zaman, muncul berbagai masalah sosial yang perlu penanganan lebih lanjut, seperti pudarnya semangat persatuan dan kesatuan, terjadinya intoleransi, individualisme, saling menebar hoax, fitnah, turunnya semangat gotong royong dan sebagainya. Untuk itulah diperlukannya penguatan kembali semangat berbangsa dan bernegara, membangun solidaritas sosial guna memperteguh kebhinnekaan dan jatidiri bangsa serta memperkuat Restorasi Sosial Indonesia. Berbagai cara dapat dilakukan guna mengembalikan kebhinnekaan dan jatidiri bangsa Indonesia, antara lain melalui kebijakan memperkuat pendidikan karakter dan menciptakan ruang-ruang dialog antarwarga, bergotong royong dan saling memberi serta membantu dan menghormati antar sesama warga bangsa. Oleh karena itu, melalui penulisan buku Restorasi Sosial ini diharapkan dapat menjadi sebuah pemikiran guna memperkokoh kembali rasa kebersamaan dan kebanggaan sebagai bangsa yang yang maju dan bermartabat.
Measuring Psychological Need States in Sport: Theoretical Considerations and a New Measure
Authors: Bhavsar Nikita , Bartholomew Kimberley , Quested Eleanor , Gucciardi Daniel , Thøgersen-Ntoumani Cecilie , Reeve Johnmarshall , Sarrazin Philippe , Ntoumanis Nikos
Published: May 2019

Research guided by Self-determination Theory (Deci & Ryan, 1985; Ryan & Deci, 2017) has repeatedly demonstrated the importance of focusing on both the bright (satisfaction) and dark (frustration) sides of the three basic psychological needs. Recently, researchers have also argued for the utility of assessing a third need state, that of “unfulfillment”. In this paper, we outline an effort to develop and provide initial validity evidence for scores of a new multidimensional and sport-specific measure, the Psychological Need States in Sport-Scale (PNSS-S), to assess the satisfaction, frustration, and unfulfillment of all three needs. In Study 1, we tested evidence for the factorial structure of the responses to the newly developed items, and provided evidence for the internal consistency and discriminant validity of the subscale scores. Factor models incorporating all three need states showed poor fit with the data. However, following post-hoc modifications, a six-factor, 29-item model assessing the need states of satisfaction and frustration, separately for autonomy, competence, and relatedness, was found to have good fit to the data. The model was refined and the factor structure was re-tested using an independent sample of athletes in Study 2. Evidence for the nomological network of the six subscales of the new measure was demonstrated in Study 2, in terms of relations with athletes’ perceptions of their coaches’ interpersonal behaviors, and key motivation-related outcomes. In conclusion, a tripartite conceptualization of the need states was not empirically supported. Nevertheless, , the PNSS-S makes a unique contribution to the sport literature, as it represents the first sport-specific measure of six distinct, yet, correlated states of the satisfaction and frustration of autonomy, competence, and relatedness needs.
The Yellow Vests Movement - a case of long transient dynamics?
Authors: Morozov Andrew , Petrovskii Sergei , Gavrilets Sergey
Published: May 2019

Understanding the dynamics of protests and social unrest is important in order to ensure a stable, sustainable development of the society. Mathematical models of social dynamics have been increasingly recognised as a powerful research tool in achieving this goal. Here, motivated by the fact that the dynamics of the ongoing Yellow Vest Movement in France exhibit anomalously long duration (currently it is in 30th week), we explore whether this can be a result of a dynamical systems phenomenon known as long transients. To this end, we build and study a hierarchy of mathematical models describing the "population dynamics" of the movement, i.e. how the number of protesters changes with time. We show that in these models long transients appear via two roots: via a ghost attractor and via an interaction of the slow and fast dynamics. We demonstrate that long transients are also present in some earlier models of social protests. Interestingly, our models predict that the Yellow Vest Movement should end abruptly by, at the latest, mid-summer 2019 without any interference from the French government. More generally, we argue that long transients are a generic feature of dynamical models describing social processes in the same way as they are in models of physical, ecological, and evolutionary systems.
Combined Mammographic and Sonographic Evaluation of Palpable Breast Mass
Authors: Badu Muna , Simkhada Rabindra
Published: May 2019

INTRODUCTION: Detection and evaluation of breast mass is challenging. Identification of malignancy in earliest possible stage is rewarding. Several radiological diagnostic modalities are available for this purpose including mammography and ultrasonography. The objective of the study was to evaluate the accuracy of mammography and ultrasonography individually and in combination to detect and characterize palpable breast mass and to correlate the imaging findings with histopathology.

MATERIAL AND METHODS: Patients presented with palpable breast lump were examined prospectively. All patients were examined by both mammography and ultrasonography. Fine needle aspiration cytology was done for all findings. Correlations of mammography and ultrasonography findings were done with histopathology.

RESULTS: A total of 42 patients were evaluated. Fine needle aspiration cytology revealed 30 (71.42%) benign and 12 (28.58%) malignant lesions. The sensitivity and specificity for mammography were 83.33% and 93.33% and for ultrasonography were 81.81% and 90.32% respectively. When findings of mammography and ultrasonography were combined, both sensitivity and specificity were increased to 91.66% and 96.66% respectively.

CONCLUSION: Combined mammography and ultrasonography had higher sensitivity and specificity rate than sensitivity and specificity rate observed for either of single modality. This study suggests that any patient who is advised to go for a single modality of investigation should rather be investigated using the combined modality.
Readmissions for Morbidities among Women within the Puerperium
Authors: Raut Bhaktabatsal
Published: May 2019

INTRODUCTION: There are varieties of morbidities which occurs during the postpartum period. The type and severities of such morbidities will determine the need for hospital readmission and appropriate treatment. To analyze the maternal morbidities among postpartum women who have been readmitted following discharge from the hospital after delivery.

MATERIAL AND METHODS: This was a hospital based descriptive study which was conducted including all women readmitted for postpartum complications within the puerperium after having been delivered at Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu. The variables considered for study were pattern of postpartum morbidities, age and parity of women, mode of delivery and average duration of hospital stay.

RESULTS: The incidence of maternal postpartum readmission after having been delivered in study hospital was 1.25% (n= 80), out of which puerperal sepsis was the most frequent diagnosis comprising 37.5% (n=30), followed by secondary PPH 30% (n=24), urinary tract infections and hypertensive disorders of pregnancy. Seventy percentage of women were within the age group of 20-29 yrs and 56.3% were primipara. When proportion of morbidities were analyzed among age groups of ≤19yrs and ≥ 20 yrs, and primiparity and multiparity, showed statistically insignificant difference. Sixty-six (82.5%) women had vaginal delivery and 14 (17.5%) had caesarean section. The percentage of readmission for postpartum morbidity among caesarean delivery was 1.43%, and in vaginal delivery, it was 1.22% . But this difference was statistically not significant (p value = 0.59).The average duration of hospital stay for postpartum morbidities was 4.53 days.

CONCLUSION: The incidence of maternal readmission for postpartum morbidities after having been delivered in the study hospital was 1.25%, of which infectious morbidity was the commonest one. There is no statistically significant difference among morbidities between different age and parity groups. Women who had caesarean delivery were more likely to have postpartum morbidity requiring hospital readmission than women who had vaginal delivery but this difference was statistically not significant. Prevention and adequate treatment of infections in pregnancy, labor, delivery and postnatal period, and more stringent management of hypertensive disorders of pregnancy are mandatory to reduce the incidence of postpartum morbidity.
Challenges & Issues: Evidence-Based Clinical Skills Teaching and Learning: What Do We Really Know?
Authors: Malone Erin
Published: May 2019

The recent programmatic focus on skills development in veterinary medicine means that many programs are devoting increased time to formal clinical skills teaching. This expansion makes it essential that we use the time as effectively as possible. This review examines current practices and veterinary training principles using the broader field of evidence-based motor skills learning as a lens. In many areas, current practices may be hindering learning. Proposed practices include using videos and discussions for pre-laboratory training, focusing on a single complex skill at a time, using more near-peer instructors rather than faculty, including assessments in each teaching or practice session, and encouraging supervised distributed practice by incorporating practice sessions into the formal curriculum. Ensuring mastery of a few core skills rather than exposure to many may be the new goal. Further research is urgently needed on block versus spiral curricula, optimum instructor-to-student ratios, learning and practice schedules, hours required for proficiency, and the benefits of exercise on motor skills learning.
Estresse | ansiedade | aromaterapia: Pelo olhar da Osmologia, ciência do olfato e do odor
Authors: Oliveira Carlos Jorge Rocha , Amaral Fernando do
Published: May 2019

Nesta breve revisão, buscamos estabelecer o estado da arte sobre o tema com a definição de estresse / ansiedade  como resposta do organismo ao meio através de agentes estressores. Analisamos a realidade das doenças no mundo e no Brasil tendo como percepção a realidade do dia a dia das pessoas. Buscamos dar entendimento ao estresse como modulador da resposta do indivíduo na forma de comprometimento da cognição, emoção e comportamento. Fizemos propostas de ações técnicas práticas inovadoras dentro das especialidades com envolvimento dos óleos essenciais / aromaterapia e analisamos os dados da pesquisa científica sobre óleos essenciais / aromaterapia que buscam qualificar seu uso em quantidade e tempo dependente para sua eficácia. Os procedimentos utilizados no presente trabalho foram: 1. Pesquisa bibliográfica sobre o tema nas principais bases de dados – Biblioteca Virtual em Saúde (BVS); Scientific Electronic Library Online (SciELO), U. S. National Library of Medicine (PubMed).  2. Reflexão crítica sobre o material obtido e 3. Elaboração de sínteses a respeito do tema.
Nefrocalcinose medular bilateral por ingestão de Zantedeschia aethiopica (copo de leite) em filhote canino: Relato de caso
Authors: Perin Rayzza
Published: May 2019

The ornamental plant Zantedeschia aethiopica, commonly known as "milk cup", contains calcium oxalate idioblasts in its leaf blade, petiole and spathe. This component is toxic to the body and may cause gastrointestinal, renal and hepatic disorders, with clinical signs being variable and the diagnosis based mainly on the history of accidental ingestion of the plant. One of the alterations that can be found in these cases is the presence of these crystals of oxalate in the kidneys, generating a nefrocalcinosis. The objective of this work was to report an occurrence of spinal cord nephrocalcinosis by ingestion of Zantedeschia aethiopica in a canine puppy.
Osteopatia hipertrófica em cadela secundária a metástase pulmonar de neoplasia mamária: Relato de caso
Authors: ALBERIGI Bruno , Christianini Belz de Melo Marina , Helms Jamile , Soares Denise
Published: May 2019

Hypertrophic osteopathy is a paraneoplastic disorder characterized by periosteal bone neoformation that is usually associated with primary neoplasms or pulmonary metastases. The diagnosis is made through history, anamnesis, physical and radiographic examinations. The treatment is based on regression of clinical signs with removal of the primary cause, with the prognosis ranging from reserved to unfavorable according to the possibility of resolution of the primary process. A patient of the canine, female, 12-year-old female, without a defined breed, was treated with pain and enlargement in the thoracic limbs, lameness and reluctance to walk. With the findings of the physical examination and radiographic examination associated with the history of previous mammary neoplasia, bone paraneoplastic syndrome was suspected. The present report aims to describe a case of hypertrophic osteopathy secondary to pulmonary metastasis of breast neoplasia in a female dog, describing clinical findings and radiographic examination as diagnostic support and clinical evolution.
Fatores antinutricionais de importância na nutrição animal: Composição e função dos compostos secundários
Authors: De souza Carla Giselly , Moura Andrezza Kyarelle Bezerra de , Silva Jennifer Nandes Pereira da , Soares Kilmer Oliveira , Silva Joelma Vasconcelos Celestino da , Vasconcelos Priscylla Carvalho
Published: May 2019

Anti-nutritional factors are substances that even in vestigial state, reduce or prevent the use of a nutritional element. These anti-nutritional factors, most of which are secondary metabolites, which can be defined as compounds that have no recognized role in the maintenance of vital plant processes that synthesize them, in contrast, play an important role in the interaction of the plant with its environment. Anti-nutritional factors are usually not seen with "good eyes". Although the term anti-nutritional factors refer only to the "bad" characteristics of these substances, it is worth remembering that they are not only responsible for generating adverse effects. On the contrary, virtually all of them, if not all, are capable of conferring, also, possible beneficial effects to the animal organism. Some phenolic compounds of greater representativeness in the animal feed, are: tannins, lignins and gossypol. However, there are also saponins, mimosins, phytate, lectins, protease inhibitors and cyanogenic glycosides. All present in the plants, each with its particularity that will be explained throughout this review.
Peran Pemuda dalam Pengembangan Wisata di Desa Pongkar Kabupaten Karimun
Authors: Akbar Dhani , Setiandika Igiasi Teguh
Published: May 2019

Struktur masyarakat yang berada di Desa Pongkar Kabupaten Karimun terdiri dari beragam latar belakang kebudayaan meskipun masih didominasi oleh Melayu. Namun keberadaan komunitas suku laut yang merupakan bagian dari konsep Komunitas Adat Terpencil dalam Undang-undang, menjadikan wilayah Desa Pongkar menjadi lebih menarik dalam mengembangkan wisata berbasis kearifan lokal masyarakat setempat. Butuh adanya peleburan budaya dalam merencanakan pengembangan potensi ekowisata berbasis kearifan lokal di Desa Pongkar Kabupaten Karimun. Sehingga semua kebudayaan masyarakat di Desa Pongkar terakomodir dan tidak ada nilai-nilai masyarakatnya yang cukup beragam tersebut yang tercederai. Metode yang dipakai untuk mendapat data dalam penelitian ini adalah metode kualitatif maka ada komponen-komponen metode kualitatif yang harus diperhatikan oleh peneliti. Partisipasi pemuda dalam program sadar wisata seharusnya memang digalakkan sebagai sebuah pembelajaran bagi para pemuda bahwa mereka juga punya peran dan tanggung jawab dalam memajukan desanya. Hal ini juga yang sedang dilaksanakan oleh desa Pongkar, yang berada di Kecamatan Tebing, Kabupaten Karimun, Provinsi Kepulauan Riau. Partisipasi para pemuda di desa Pongkar bisa dikatakan cukup baik, namun alangkah baiknya tidak saja berperan dalam partisipasi tapi juga ikut ambil bagian dalam pengembangan desa tersebut karena bisa saja timbul banyak pemikiran-pemikiran yang lebih segar.
Implementasi Program Dana Alokasi Khusus (Dak) Sub Bidang Prasarana Pemerintahan Daerah Tahun 2016
Authors: Wijaya Mendra , Handrisal Handrisal
Published: May 2019

Kajian ini dipilih karena adanya kebijakan pemerintah untuk melakukan pemangkasan anggaran terhadap Dana Alokasi Khusus (DAK) pada tahun 2016. Pemangkasan DAK tersebut tentu saja berdampak pada implemntasi program pembangunan di daerah yang bersumber dari DAK terutama untuk Sub Bidang Prasarana Pemerintahan Daerah. Analisis data dalam laporan ini didasarkan pada data sekunder yang diambil dari statistik dan pelaporan DAK di 19 Provinsi, laporan kegiatan, dokumentasi program, dan semua bahan yang tersedia di perpustakaan dan juga di unit penyimpan arsip atau data. Hasil kajian menemukan bahwa kebijakan pemerintah dengan memotong/mamangkas anggaran DAK telah memberikan pengaruh dalam mengimplementasikan DAK di tingkat daerah terutama untuk Sub Bidang Prasarana Pemerintahan Daerah, selain itu juga masih terdapat hambatan dalam melakukan monitoring dan evaluasi yang disebabkan oleh sangat terbatasnya koordinasi di antara pemerintah pusat dengan pemerintah daerah.
Hair loss: A review of the role of food bioactive compounds
Authors: Wei Grace , Martirosyan Danik
Published: May 2019

Background: The impact that hair loss has on an individual's psychological wellness, and subsequent quality of life, is widespread and long lasting. The current standard treatments for hair loss include surgery and medications, ranging from over-the-counter treatments to corticosteroid injections and immunosuppressants. Unfortunately, these current treatments are either expensive, invasive, or have extremely negative side effects. Recently, the role of vitamins, minerals, and functional foods with their associated bioactive compounds, have gained increasing recognition as a potential means to address this issue. Some of these compounds have been shown to decrease the risk of specific forms of hair loss, particularly alopecia, a form of balding that results due from an autoimmune disorder. These include experimental studies using black raspberry extract and egg yolks as well as epidemiological studies using Mediterranean diets and various micronutrients. Other compounds have been shown to promote hair growth on a more general scale, including in vivo studies using rice bran extract and mouse models using red ginseng oil and annurca apple polyphenols. This review identifies key hair growth promoting vitamins, minerals, and functional foods, as well as summarizes the relevant mechanisms of action of these compounds that have been elucidated. Knowledge regarding the effects of these nutriceuticals on reducing hair loss is rapidly expanding. However, it is imperative that further research be done in order to delineate mechanisms of actions for all compounds related to managing and treating hair loss and subsequently integrate these dietary modifications into clinical treatment recommendations for hair loss.Keywords: Hair loss, alopecia, berry extract, mediterranean diet, rice bran, ginseng, annurca apple, thuja orientalis, marine supplement, honey, egg yolk, functional foods, bioactive compounds
Relaxant mechanism of Eulophia macrobulbon ethanolic extract and 1-(4΄-hydroxybenzyl)-4, 8-dimethoxyphenanthrene-2,7-diol on human corpus cavernosum
Authors: Jansakul Chaweewan , Yorsin Somreudee , Naphatthalung Jomkarn , Tachanaparugse Kuldej , Changwichai Kanokwan , Chootip Krongkarn , Ingkaninan Kornkanok
Published: May 2019

Background: Eulophia macrobulbon (E.C.Parish & Rchb.f.) Hook.F. has been shown to be a promising phosphodiesterase-5 (PDE5) inhibitor that relaxes rat isolated pulmonary artery.Objective: To test this plant’s possible application in human erectile dysfunction (ED) using an ethanolic extract of E. macrobulbon tubers (EM extract), and an isolated constituent, 1-(4΄-hydroxybenzyl)-4, 8-dimethoxyphenanthrene-2,7-diol (HDP).Methods: Dried tubers of EM were extracted with 95% ethanol and the HDP was isolated by several chromatographic methods. The relaxant mechanism of the EM extract and the HDP was studied on isolated human cavernosal strips (HC strip).Results: EM extract (0.1-3 mg/ml) relaxed HC strips precontracted with phenylephrine. The relaxant effect was not modified by N-nitro-L-arginine (L-NNA), ODQ, tetraethylammonium, nor glybenclamide. HDP (0.1-3 mM) relaxed HC strips precontracted with phenylephrine to the same extent as that of sildenafil. EM extract and HDP potentiated relaxation of the HC strips to glyceryl trinitrate in a similar manner to that of sildenafil. EM extract and sildenafil, but not HDP, increased cGMP content of the HC strips in a concentration-dependent manner. In the thapsigargin-pretreated HC strips, nifedipine or EM extract, but not HDP, suppressed the contractile response of the HC strips to phenylephrine. When nifedipine and/or SKF 96365 (stored-operated Ca2+ channel blocker) was added, followed by EM extract or HDP, further suppression was found in the case of HDP but not with EM extract. Ca2+ free Krebs solution suppressed the phenylephrine contraction on HC strips and further suppression was found when adding EM extract or HDP.Conclusion: These results indicate that EM extract causes a relaxation of HC strips by serving as an inhibitor of PDE5, of voltage- and stored-operated Ca2+ channels, and of intracellular Ca2+ mobilization. Thus EM extract might be a good choice for development as a functional food for erectile dysfunction in men. However, further studies are needed to identify other PDE5 and the Ca2+channel inhibiting components of the extract.
Redox-dependent and independent mechanisms of selective pro- and anti-apoptotic activity of Georgian legumes crops extracts on Jurkat and MDCK cells
Authors: Sanikidze Tamar V. , Maminaishvili Tinatin L. , Kipiani Nana V. , Enukidze Maia G. , Machavariani Marine G. , E.R Shekiladze , Ormotsadze Giorgi L.
Published: May 2019

Background: Possibilities of pharmacological regulation of apoptosis play an important role in the treatment of different diseases. Polyphenol-rich plant extracts, as well as isolated polyphenols, can regulate cell apoptosis primarily through intrinsic and extrinsic mechanisms of action and are the most intriguing and studied class of compounds that can be therapeutics for a wide range of common diseases, including cancer. Polyphenols are well known as powerful antioxidants, their action is also associated with pro-apoptotic function in various types of tumor cells.The purpose of this study was to establish the anti-and pro-apoptotic activity of Georgian legume crops in model cellular systems.Methods: Legume crop extracts (LCEs) were prepared in water-alcohol solute. Polyphenols content in the extracts was determined by Folin–Ciocalteu method, antiradical activity (AA) - according the comparative time of the 50% neutralization of 2,2-diphenyl-1-picrylhydrazyl (DPPH) cleavage.Studies were carried out on human leukemic mature T (Jurkat) and normal epithelial MDCK cells lines. For modelling of oxida­tive stress, 30% hydrogen peroxide was used. LCEs were added to intact or incubated under oxidative stress conditions Jurkat and MDCK cells. Cells’ viability was determined by 3-(4,5-dimethyltiazol-2)-2,5-diphenyl-tetrazolium-bromide (MTT) test. Catalase and Superoxidedismutase (SOD) activity in cellular supernatant was measured by spectrophotometry.Results: LCEs revealed selective pro- and antiapoptotic activity on the intact and incubated under oxidative stress conditions Jurkat and MDCK cells. The cytotoxic effect of LCEs on intact Jurkat and MDCK cells was independent of their AA and activity of enzymatic cellular antioxidant defense system.The cytoprotective effect of LCEs on MDCK cells was realized through redox-dependent mechanisms and is associated both with the own AA of the extracts and with the stimulating effect of the extracts on the activity of enzymatic cellular antioxidant defense system, where catalase played a leading role. LCEs didn’t protect Jurkat cells from oxidative stress-induced apoptosis.Conclusion: The obtained results allow us to conclude that in cancer chemotherapy the legume extracts might be combined with prooxidant drugs, in order to protect normal cells, but not the malignant ones, from their apoptosis-inducing effect. On the other hand, these extracts may protect non-malignant tissues/organs from various apoptosis-related disorders.
An Ana-Ano-MBR system for nutrient removal from brewery wastewater at various nitrate recirculation ratios
Authors: Van Thien Nu Thai , Dang Hung Viet , Nguyen Hoa Thi Thanh
Published: May 2019

Anaerobic and anoxic variations were combined with membrane bioreactor to form an Anaerobic/Anoxic configuration in MBR-based (Ana-Ano-MBR) system for improving the system performance in terms of organic degradation and nutrient removal from brewery wastewater. The model of Ana-Ano-MBR system made from polyacrylic with the capacity of 42 liters was operated with organic loading rate of 0.75 kgCOD/m3.day. The results showed that for the nitrate recycling ratios of 100, 200, 300%, average NH4+-N and TN removal efficiencies of the model were 95.1 and 76.6, 98.5 and 89.6, 98.9 and 90.2%, respectively, and the output values of NH4+-N and TN were within the limits of Vietnam National Standards (QCVN 40:2011/BTNMT, column A). Treatment efficiencies of COD and TP were over 90% and below 60%, respectively, during the whole experiment period. Low phosphorus removal efficiency was the drawback of Ana-Ano-MBR system due to the lack of appropriate system configuration and operational conditions for PAOs’ growth and activity.
Evaluating salinity intrusion in estuaries using remote sensing data integrated in-situ observation
Authors: Nguyen Vu Nguyen , Le Trung Van , Tran Van Thi
Published: May 2019

Saline intrusion reduces crop productivity, causes land degradation, decreases water quality, and severely affects agricultural production, the environment as well as livelihoods. Under the evolution of climate change and human activities from the upstream of the Mekong, the downstream areas of Dinh An and Cung Hau estuaries in Tra Vinh province are also significantly affected by saline intrusion from the East Sea. This article presents the integrated solution of remote sensing and GIS in monitoring and mapping salinity intrusion. The data used are Landsat 8 satellite images combined with salinity water monitoring data collected from actual observation stations during the dry season. Analysis showed that there was a statistically significant correlation between the observed salinity value of the water and the pixel value of the first principal component image. Simulation of spatial distribution from the study indicates that saline intrusion is now entering the interior with a distance from the estuary to about 30 - 48 km depending on the time of the dry season. The results of this study will assist managers in planning food safety strategies at the risk of saline intrusion.
THE APOPTOTIC EFFECT OF RESVERATROL ON HUMAN PAPILLOMA VIRUS POSITIVE CASKI CELL-LINE: A TIME AND DOSE DEPENDENCE STUDY.
Authors: Rani Dr. Reena , Singh Dr. Anupam Kumar , Khan Dr. Samreen , Islam Prof. Najmul
Published: May 2019

Background & objectives: Resveratrol (trans-3,4,5’ –trihydroxystilbene) is an active compound in food, such as redgrapes, peanuts, and berries. A body of evidence shows that resveratrol is able to inhibit thegrowth of many cancers such as leukemia, breast cancer and primary brain tumors. The objective of the present study was to demonstrate the dose and time dependent apoptotic effect of Resveratrol on Human Caski cell line.

Methods: We used cell viability assays like MTT and Trypan blue assays to demonstrate the inhibition of cancer cell proliferation in a dose and time dependent manner.

Results: Our results have shown that Resveratrol inhibited proliferation of Caski cells in a concentration and time dependent manner in 48 hr cultures. No significant effect was observed in 24 hour cultures of cell viability assays.

Interpretation & conclusions: The results indicated that Resveratrol and NAC inhibited cell growth in Caski cells as a function of dose and time.

Keywords: Resveratrol , Cervical cancer, apoptosis
El Plan de Acción para la Internacionalización de la Economía Española 2019-2020
Authors: Estrategía de Internacionalización Subdirección General de
Published: May 2019

El Consejo de Ministros aprobó, por el Acuerdo de 29 de marzo de 2019, el Plan de Acción para la Internacionalización de la Economía Española 2019-2020, segundo plan bienal que desarrolla la Estrategia de Internacionalización de la Economía Española 2017-2027. El plan ha sido elaborado por el Ministerio de Industria, Comercio y Turismo a través de la Secretaría de Estado de Comercio, con la participación de todos los ministerios con actividad en materia de internacionalización, consultadas las comunidades autónomas y el sector privado. Su objetivo principal es impulsar la internacionalización de la economía española, afianzando el dinamismo del sector exterior y su impacto positivo sobre el crecimiento económico y el empleo, a través de la mejora en la competitividad y de la mayor presencia de nuestras empresas en el exterior.
Toku toa, he toa rangatira: A qualitative investigation of New Zealand Māori end of life care customs
Authors: Moeke-Maxwell Tess , Wharemate Rawiri , Black Stella , Mason Kathleen , Wiles Janine , Gott Merryn
Published: May 2019

Informal end of life caregiving will increase over the next 30 years in line with the anticipated increase in older Māori deaths. Of concern, New Zealand’s neo-colonial trajectory (loss of lands, cultural disenfranchisement, urban migration, ethnic diversity, global diaspora and changing whānau (family, including extended family) compositions) has restricted some indigenous whānau from retaining their end of life care customs. This article reports on a qualitative pilot study on Māori whānau end of life care customs undertaken to explore how those care customs contribute towards strengthening whānau resilience and bereavement. Five whānau, including thirteen individuals from diverse iwi (tribes), took part in one of six face to face interviews. Kaupapa Māori research methods informed the analysis. The findings report a high level of customary caregiving knowledge among older whānau carers as well as a cohesive whānau collective support system for this group. Tribal care customs were handed down via 1) enculturation with tribal principles, processes and practices 2) observing kaumātua processes and practices and 3) being chosen and prepared for a specific care role by kaumātua. Younger participants had strong cultural care values but less customary care knowledge. The pilot concluded the need for a larger systematic qualitative study of Māori tikanga (customs) and kawa (guidelines) as well as the development of participant digital stories to support a free online educational resource to increase understanding among whānau, indigenous communities and the health and palliative care sectors.
Death and Dying
Authors: Stewart Suzanne , Mashford-Pringle Angela
Published: May 2019

In this issue, we explore three articles about Indigenous knowledge, ceremonies and experiences about the effects of death and dying on Indigenous people. Articles included describe different point of views on a topic that is considered "taboo", however death and dying affect all of us in different ways. These articles are intended to open space for conversations Indigenous death and dying.
Moving and Enhancing System Change
Authors: Stewart Suzanne , Mashford-Pringle Angela
Published: May 2019

All Indigenous peoples across the globe have experienced multiple historical colonial aggression and assaults. In Canada and the USA for example, education was used as a tool of oppression for Indigenous peoples through residential school. Child welfare, health and health care, and forced land relocation are also sites of intensive and invasive harms. Health services continue to be a site of systemic and personal oppression for Indigenous peoples across Canada and the world (Reading 2013). For many years, Indigenous peoples have faced discrimination and racism when accessing biomedical health care. Implementation of colonization in Canada, Australia, New Zealand, and elsewhere, have been well documented to adversely influence aspects of health in many Indigenous communities worldwide and linked to high rates of mental health, education, and employment challenges (see Loppie & Wein, 2009; Mowbray, 2007; Paradies, Harris, & Anderson, 2008); these traumas are rooted attempts in cultural extermination and deep-set pains in regard to identity and well-being (Stout & Downey, 2006; Thurston & Mashford-Pringle, 2015).
Moving Systems to Cultural Safety
Authors: Stewart Suzanne , Mashford-Pringle Angela
Published: May 2019

All Indigenous peoples across the globe have experienced multiple historical colonial aggression and assaults. In Canada and the USA for example, education was used as a tool of oppression for Indigenous peoples through residential school. Child welfare, health and health care, and forced land relocation are also sites of intensive and invasive harms.
Growth and yield of okra influenced by different types of fertilizers and netting
Authors: Muqtadir MA , Islam MA , Haque T , Nahar A
Published: May 2019

An experiment was conducted at the Horticulture Farm of Bangladesh Agricultural University, Mymensingh during the period from March 2017 to June 2017 with a view to evaluate the effect of different types of fertilizer and netting on the growth and yield of okra. The experiment consisted of 4 levels of fertilizer following cow dung 15 t/ha (F1), inorganic fertilizer (NPK) (F2), combined application of cow dung (2/3) + inorganic fertilizer (1/3) (F3), control (F4) and 2 levels of mosquito netting (N0 = control with no netting, N1=blue colour Netting). The experiment was laid out in Randomized Complete Block Design (RCBD) with 3 replications. Overall, the growth like plant height, leaf length, pod length, pod diameter and pods numbers of okra was found higher from the combined effect of F3N1 which was significantly different from other treatments combination. The lowest growth and yield of okra was found from the treatment combination of F4N0 (control). First flowering were observed in F3N1 at 39 days after planting of okra seeds. The control treatment without net gave the lowest production of okra compared to combination of inorganic fertilizer and cow dung with netting.  In case of fertilizers effect, the highest yield (16.06 t/ha) was found from F3.  Blue colour net gave the highest yield (10.99 t/ha) compared to without net (8.88 t/ha). The highest yield of okra (17.55 t/ha) was found from the combined effect of F3N1 which was 78.52% higher compared to control treatment combination F4N0 (3.77 t/ha).

Progressive Agriculture, Vol. 30, Suppl. 1: 1-9, 2019