bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst
Authors: Murata Takatsugu , Kawanishi Tatsuya , Sekiguchi Akihiro , Ono Keisuke , Nakata Kenya , Shiina Isamu
Published: August 2018

Various optically active 2-hydroxyamide derivatives are produced based on the kinetic resolution of racemic 2-hydroxyamides with a diphenylacetyl component and (R)-benzotetramisole [(R)-BTM], a chiral acyl-transfer catalyst, via asymmetric esterification and acylation. It was revealed that a tertiary amide can be used with this novel protocol to achieve high selectivity [22 examples; s-value reaching over 250]. The resulting chiral compounds could be transformed into other useful structures while maintaining their chirality.
Biofilm removal and bacterial re-colonization inhibition of a novel erythritol/chlorhexidine air-polishing powder on titanium disks.
Authors: MENSI MAGDA , COCHIS ANDREA , SORDILLO ANNAMARIA , UBERTI FRANCESCA , RIMONDINI LIA
Published: August 2018

Abstract: Air-polishing with low abrasiveness powders is fats arising as a valid and mini-invasive instrument for the management of biofilm colonizing dental implants. The reported advantage is the efficient removal of plaque with respect of the titanium integrity. In the present study, we evaluated the in-situ plaque-removal and continual the post-treatment anti-bacterial efficacy of an innovative erythritol/chlorhexidine air-polishing powder and compared it with sodium bicarbonate. Two peri-implantitis-linked biofilm formers strains Staphylococcus aureus and Aggregatibacter actinomycetemcomitans were selected and used to infect titanium disks before and after the air-polishing treatment. Cells number and viability were assayed by colonies forming units (CFUs) count and metabolic-colorimetric (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide) (XTT) assay. Air-polishing performed with either sodium bicarbonate or erythritol/chlorhexidine was effective in reducing bacteria biofilm viability and number onto pre-infected specimens, while erythritol/ chlorhexidine showed a higher post-treatment biofilm re-growth inhibition. Surface analysis via mechanical profilometry failed to show an increase in titanium roughness, regardless of the powder selected.
Periorbital Hyperpigmentation, a Dermatologic Condition Having a Strong Geographic and Ethnic Determinism
Authors: Andrei Felicia , Grujic Daciana , Lazar Cristina , Dragomirescu Anca
Published: August 2018

POH (Peri Orbital Hyperpigmentation) represents a minor clinical entity that attracts immense aesthetic damages and it generates social integration difficulties. This review focuses on the etiopathogenic causes of this entity, differentiating and reclassifying this defect as having, on the one hand, genetic causes of melanic hyperproduction – for Fitzpatrick cutaneous phototypes IV and V – and, on the other hand, both genetic and acquired vascular causes, in individuals with light-coloured skin phototypes. Hence, there is a big difference in the field of pathogenic treatment, for the two entities. In addition, this study notes the direct relationship between skin aging and POH, especially for aquired vascular causes. In this reasoning, other aesthetic deficiencies of the skin in the palpebral area should be also considered, like: blepharochalasis, wrinkles, the anatomical causes of the lower eyelid shading, symmetrical or asymmetric suborbital oedema. All of these issues will complicate the therapeutic decision and subsidiary, the pharmaceutical advice. In this context, the review shows the guidelines for a honest councelling of the patients, pointing the efficiency limit for the topical pharmaceutical medication (depigmentants, exfoliants) versus the necessity of minimally invasive or/ and surgical treatments (in blefarochalasis).
The Good, the Bad and the Uncertain: Bioenergy use in the European Union
Authors: Philippidis George , Bartelings Heleen , Helming John , M'barek Robert , Smeets Edward , van Meijl Hans
Published: August 2018

As the EU is moving towards a low carbon economy and seeks to further develop its renewable energy policy, this paper quantitatively investigates the impact of plausible energy market reforms from the perspective of bio-renewables. Employing a state-of-the-art biobased variant of a computable general equilibrium model, this study assesses the perceived medium-term benefits, risks and trade-offs which arise from an advanced biofuels plan, two exploratory scenarios of a more 'sustainable' conventional biofuels plan and a 'no-mandate' scenario. Consistent with more recent studies, none of the scenarios considered present significant challenges to EU food-security or agricultural land usage. An illustrative advanced biofuels plan simulation requires non-trivial public support to implement whilst a degree of competition for biomass with (high-value) advanced biomass material industries is observed. On the other hand, it significantly alleviates land use pressures, whilst lignocellulose biomass prices are not expected to increase to unsustainable levels. Clearly, these observations are subject to assumptions on technological change, sustainable biomass limits, expected trends in fossil fuel prices and EU access to third-country trade. With these same caveats in mind, the switch to increased bioethanol production does not result in significant market tensions in biomass markets.
A Neuro-Fuzzy Approach Based Tool Condition Monitoring in AISI H13 Milling
Authors: Alam Md. Shafiul , Aramesh Maryam , Veldhuis Stephen
Published: August 2018

In the manufacturing industry, cutting tool failure is a probable fault which causes damage to the cutting tools, workpiece quality and unscheduled downtime. It is very important to develop a reliable and inexpensive intelligent tool wear monitoring system for use in cutting processes. A successful monitoring system can effectively maintain machine tools, cutting tool and workpiece. In the present study, the tool condition monitoring system has been developed for Die steel (H13) milling process. Effective design of experiment and robust data acquisition system ensured the machining forces impact in the milling operation. Also, ANFIS based model has been developed based on cutting force-tool wear relationship in this research which has been implemented in the tool wear monitoring system. Prediction model shows that the developed system is accurate enough to perform an online tool wear monitoring system in the milling process.
Effects of Natural Antioxidant Agents on the Bitumen Aging Process: An EPR and Rheological Investigation
Authors: Oliviero Rossi Cesare , Caputo Paolino , Ashimova Saltanat , Fabozzi Antonio , D'Errico Gerardino , Angelico Ruggero
Published: August 2018

Bitumen aging is the major factor which contributes to the deterioration of the road pavement. Oxidation and volatilization are generally considered as the most important phenomena affecting aging in asphalt paving mixtures. The present study was carried to investigate whether various antioxidants provided by natural resources such as phospholipids, ascorbic acid as well as lignin from rice husk, could be used to reduce age hardening in asphalt binders. A selected bituminous material was modified by adding 2 % w/w of the anti-aging natural additives and subjected to accelerated oxidative aging regimes according to the Rolling Thin Film Oven Test (RTFOT) method. The effects of aging were evaluated based on changes in sol-gel transition temperature of modified bitumens measured through Dynamic Shear Rheology (DSR). Moreover, changes of Electron Paramagnetic Resonance (EPR) spectra were monitored on the bituminous fractions asphaltene and maltene separated by solvent extraction upon oxidative aging. The phospholipids-treated binder exhibited the highest resistance to oxidation and the lowest age-hardening effect compared to the other tested anti-oxidants. The combination of EPR and DSR techniques represents a promising method for elucidating the changes in associated complex properties of bitumen fractions promoted by addition of free radical scavengers borrowed by green resources.
Two-Step Contractions of Inverted Repeat Region and Psai Gene Duplication from the Plastome of Croton Tiglium (Euphorbiaceae)
Authors: Jo Sangjin , Kim Ki-Joong
Published: August 2018

Croton L. (Euphorbiaceae) is a very specious genus and consists of about 1,250 species, mainly distributed in tropical Asia and China. The first complete plastome sequence from the genus, Croton tiglium, is reported in this study (NCBI acc. No. MH394334). The plastome is 150,021 bp in length. The lengths of LSC and SSC are 111,654 bp and 18,167 bp, respectively. However, the length of the IR region is only 10,100 bp and includes only four rrn and four trn genes, and a small part of the ycf1 gene. We propose two-step IR contractions to explain this unique IR region of the C. tiglium plastome. First, the IR contracted from rps19-rpl2 to ycf2-trnL-CAA on the LSC/IRb boundary. Second, the IR contracted from ycf2-trnL-CAA to rrn16-trnV-GAC on the LSC/IRa boundary. In addition, duplicated copies of psaI genes were discovered in the C. tiglium plastome. Both copies were located side by side between accD and ycf4 genes, but one copy was pseudogenized because of a five-basepair (TAGCT) insertion in the middle of the gene following frameshift mutation. The plastome contains 112 genes, of which 78 are protein-coding genes, 30 are tRNA genes, and four are rRNA genes. Sixteen genes contain one intron and two genes have two introns. The infA gene is lost. Twelve large repeats were detected in the plastome. All large repeats are located in the LSC region. Also, 272 simple sequence repeats (SSRs) were identified. The penta-SSRs accounted for 45% of total SSRs, followed by mono- (32%), di- (12%), tetra (6%) and tri-SSRs (5%). Most of them were distributed in the large single copy (LSC) region (85%). In addition, 76% of the SSRs were located in the intergenic spacer (IGS). Phylogenetic analysis suggested that C. tiglium is a sister group of Jatropha curcas with 100% bootstrap support. Seven Euphorbiaceae species formed one clade with 100% bootstrap support.
Removal Characteristics of N-Nitrosamines and Their Precursorsby Pilot-Scale Integrated Membrane Systems for Water Reuse
Authors: Takeuchi Haruka , Yamashita Naoyuki , Nakada Norihide , Tanaka Hiroaki
Published: August 2018

This study investigated the removal characteristics of N-nitrosamines and their precursors at three pilot-scale water reclamation plants. These plants applies different integrated membrane systems: (1) microfiltration (MF) / nanofiltration (NF) / RO; (2) sand filtration/three-step RO; and (3) ultrafiltration (UF) / NF and UF / RO. Variable removal of N-nitrosodimethylamine (NDMA) by the RO membrane processes could be attributable to membrane fouling and feed water temperature. The effect of membrane fouling on N-nitrosamines removal was extensively evaluated at one of the plants by conducting one month of operation and chemical cleaning of the RO membrane element. Membrane fouling enhanced N-nitrosamines removal by the pilot-scale RO membrane process. This finding contributes to better understanding of variable removal of NDMA by RO membrane processes. This study also investigated the removal characteristics of N-nitrosamines precursors. The NF and RO membrane processes greatly reduced NDMA formation potential (FP), but the UF process had little effect. The contributions of MF, NF, and RO membrane processes for reducing FPs of NDMA, N-nitrosopyrrolidine (NPYR) and N-nitrosodiethylamine (NDEA) were different, suggesting different size distributions of their precursors.
Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine
Authors: Kimura Noriko , Takekoshi Kazuhiro , Naruse Mitsuhide
Published: August 2018

Pheochromocytoma and sympathetic paraganglioma (PPGL) are rare neuroendocrine tumors characterized by catecholamine production in the adrenal medulla and extra-adrenal paraganglia. PPGL with metastasis was termed malignant PPGL. However, the distinction between “benign” and “malignant” PPGLs has been debated. Currently, all PPGLs are believed to have some metastatic potential and are assigned malignant tumors (ICD-O/3) by the WHO Classification of Endocrine Organs (2017, 4th edition). Therefore, the previous categories benign and malignant PPGL have been eliminated in favor of a risk stratification approach. The Grading of Adrenal Pheochromocytoma and Paraganglioma (GAPP) is a tool for risk stratification for predicting metastasis and the prognosis of patients. At least 30% of PPGLs are hereditary, with 20 genes identified and genotype-phenotype correlations clarified. Of these, VHL, RET, and NF1 have been well investigated and are the primary cause of bilateral PCC. In addition, succinate dehydrogenase gene subunits SDHB and SDHD are strongly correlated with extra-adrenal location, younger age, multiple tumors, metastasis, and poor prognosis. Disease stratification by catecholamine phenotype and molecular profiling correlates with histological grading by GAPP. PPGLs should be understood comprehensively based on clinical, biochemical, molecular, and pathological data for patient care. A flow chart for pathological diagnosis is included.
Quantum Correlations and Permutation Symmetries
Authors: Majumdar Mrittunjoy Guha
Published: August 2018

In this paper, the connections between quantum non-locality and permutation symmetries areexplored. This includes two types of symmetries: permutation across a superposition and permutationof qubits in a quantum system. An algorithm is proposed for nding the separability class ofa quantum state using a method based on factorizing an arbitrary multipartite state into possiblepartitions, cyclically permuting qubits of the vectors in a superposition to check which separabilityclass it falls into and thereafter using a reduced density-matrix analysis of the system is proposed.For the case of mixed quantum states, conditions for separability are found in terms of the partialtransposition of the density matrices of the quantum system. One of these conditions turns out tobe the Partial Positive Transpose (PPT) condition. A graphical method for analyzing separabilityis also proposed. The concept of permutation of qubits is shown to be useful in dening a newentanglement measure in the `engle'.
World Citizens: Pathways for the Development of Eco-Citizenship in Higher Education
Authors: Domon Hélène
Published: August 2018

It is time that universities reexamine what is meant by globalization. Contemporary researchers in science and the humanities (Critchley, Chomsky, Mumford, Ostrom, Eisenstein, Ferry, Orr, Shiva, Klein, Margulis, Meadows, Capra and Tolba, just to name a few) have aptly redefined the concept of « world » as a biological and cultural ecosystem. This paper seeks ways to integrate the theory and practice of eco-citizenship into various cross-disciplinary aspects of higher education, with a focus on curricular adjustments that may be steered by World Languages and Cultures programs. While "global citizenship" is still often understood today as a form of supranational citizenship that may find its actualization through the valuable, yet often arrested efforts of the United Nations, or as the individualistic result of a neoliberal economic emancipation of markets and capital throughout the world, this notion must rather be embedded within a radically cultural, natural and ethical bedrock from which a more potent world citizenry will stem. Departments of World Languages and Cultures and cultures are ideally positioned in the academic landscape to foster the development of a greater eco-civic and biospheric awareness that can permeate new curricular orientations of universities in the US and abroad.
Effect of Randomisation to 6-Month Mediterranean versus Low-Fat Diet Intervention on Inflammation and Adiposity in Patients with Coronary Heart Disease; Preliminary Results of the AUSMED Heart Trial
Authors: Mayr Hannah L. , Itsiopoulos Catherine , Tierney Audrey C. , Kucianski Teagan , Radcliffe Jessica , Thomas Colleen J.
Published: August 2018

The Mediterranean diet (MedDiet) is recognised to reduce risk of coronary heart disease (CHD), in part, via its anti-inflammatory properties. Diet efficacy via this mechanism is however unclear in patients with diagnosed CHD. This study aimed to determine the effect of MedDiet versus low-fat diet intervention on inflammatory biomarkers and adiposity in a pilot cohort of Australian patients post coronary event. Participants (62±9 years, 83% male) were randomised to the MedDiet (n=34) or low-fat diet (n=31). At 0-, 3- and 6-months, dietary counselling, anthropometry, body composition (Dual-energy X-ray Absorptiometry) and venepuncture was conducted. Participants adhered well to the MedDiet intervention, however, there were no significant changes in body composition or inflammatory biomarkers hs-C-reactive protein or hs-interleukin-6 in the MedDiet compared to the low-fat diet group after 6-months. Adiponectin, an anti-inflammatory adipokine, tended to increase in response to the MedDiet (+1.1±4.2ng/mL, p=0.11) and decrease in response to the low-fat diet (-0.9±3.3ng/mL, p=0.20). In the pooled cohort, participants with greatest improvement in MedDiet adherence score had significantly lower waist circumference and subcutaneous fat levels at 6-months. A clinically significant effect of the MedDiet on inflammation and adiposity in CHD patients may require a larger sample, adjunct exercise intervention and/or caloric restriction.
Role of PhaC Type I and Type II Enzymes during PHA Biosynthesis
Authors: Mezzolla Valeria , D'Urso Oscar Fernando , Poltronieri Palmiro
Published: August 2018

PHA synthases (PhaC) are grouped into four classes based on the kinetics and mechanisms of reaction. The grouping of PhaC enzymes into four classes is dependent on substrate specificity, according to the preference in forming short chain length (scl) or medium chain length (mcl) polymers: class I, class III, and class IV produce scl-PHAs depending on propionate, butyrate, valerate and hexanoate precursors, while class II phaC synthesize mcl-PHAs based on the alkane (C6 to C14) precursors. PHA synthases of class I, in particular PhaCCs from Chromobacterium USM2 and PhaCCn/RePhaC1 from Cupriavidus necator/R. eutropha, have been analysed and the crystal structures of the C-domains have been determined. PhaCCn/RePhaC1 was also studied by small angle X-ray scattering (SAXS) analysis. Models have been proposed for dimerization, catalysis mechanism, substrate recognition and affinity, product formation and product egress route. The assays based on amino acid substitution by mutagenesis have been useful to validate the hypothesis on the role of amino acids in catalysis and in accommodation of bulky substrates, for the synthesis of PHB co-polymers and medium chain length-PHA polymers with optimized chemical properties.
Relevance of Team Cohesion in Training of Track and Field Athletes: A Review
Authors: D'souza Hamish , Walmiki Ravindra , Mane Manohar
Published: August 2018

Team spirit is often considered a peculiar characteristic of sportspersons. While the importance of unity among athletes is evident in team games, its relevance in the training of sportspersons of individual sports, especially track and field athletics, is often not recognized. The purpose of this study is to review how team cohesion impacts athletes of various sports and understand how it could contribute to the overall performance of track and field athletes, who mainly compete individually.
Statins Improve the Long-term Survival in the Survived Sepsis Patients, a Nationwide Cohort Study in Taiwan
Authors: Hsieh Ming-Shun , Liao Shu-Hui , Hsieh Vivian Chia-Rong , How Chorng-Kuang , Chiang Jen-Huai , Hu Sung-Yuan , Lee Yi-Tzu , Seak Chen-June , Chen Pau-Chung
Published: August 2018

Background:
Most sepsis patients died during their first episode and the long-term survival post discharge was low. Major adverse cardiovascular events and repeated infections were regarded as the major causes in such conditions. No definite medications were proven to effectively improve the long-term outcome. We aimed to examine the benefit of statins on the long-term outcome of survived sepsis patients.
Methods:
Between 1999 and 2013, a total of 220,082 patients with the first episode of sepsis hospitalization were included and 134,448 ones (61.09%) survived to discharge. The survived patients who subsequently had statins use of >30 cumulative defined daily doses (cDDDs) post discharge were defined as the statin users. After propensity score matching of 1:5, a total of 7,356 and 36,780 survived patients were retrieved as the study (statin-users) and comparison cohort (non-statin users), respectively. The main outcome was the long term survival post discharge. HR with 95% CI was calculated using the Cox regression model to evaluate the effectiveness of statins with further stratification analyses according to cDDDs.
Results:
The study cohort, that is, the statin users had an adjusted HR of 0.29 (95% CI, 0.27-0.31) in long term mortality rate compared with the comparison cohort. For statin users with the cDDDs of 30–180, 180–365, and >365, the adjusted HRs were 0.32, 0.22, and 0.16, respectively, (95% CI, 0.30-0.34, 0.19-0.26, and 0.12-0.23, respectively) compared with the non-statin users (defined as statins use <30 cDDDs post discharge), and the P for trend <.0001. In the sensitivity analysis, after excluding the survived patients who died within three and six months post discharge, the adjusted HR of statins use remained significant (0.35, 95% CI 0.32-0.37 and 0.42, 95% CI 0.39-0.45, respectively).
Conclusions:
Statins decreased the long-term mortality post sepsis. Further randomized control trial deserved to be conducted to confirm this observation.
Re-inventing Community Development: Utilizing Relational Networking and Cultural Assets for Infrastructure Provision
Authors: Fonchingong Charles Che
Published: August 2018

Utilizing relational networking and cultural assets provide an arena for village development associations (VDAs) to fill the gaps in infrastructure in resource limited communities of Cameroon’s north-western region. Through case study, this study interrogates the foundational thesis of relational networking and cultural assets deployed to deal with social development challenges. Semi-structured interviews were undertaken with community participants. Purposive sampling was used, and data were analysed and critically synthesized with comparable literature. Communities increasingly shoulder their own development through a multiplicity of agency with internal and external stakeholders. The analysis captures a typology of incremental cultural assets, galvanised and re-engineered, promoting a rejuvenated community. A multi-layered approach centred on intersecting elements with unvarying input from community members are perceptible. Though the translational benefits are not clear-cut, relational networking and incremental cultural assets hold out the prospect for community transformation in infrastructure provision - supply of fresh water, equipping schools, community halls, building roads, bridges and community halls. In the process, social inequality and other barriers of disadvantage are narrowed.
Effect of Heat Stress on Yield, Monoterpene Content and Antibacterial Activity of Essential Oils of Mentha X Piperita Var. Mitcham and Mentha Arvensis Var. Piperascens
Authors: Heydari Milad , Zanfardino Anna , Taleei Alireza , Shah-NejatBoushehri Ali Akbar , Hadian Javad , Maresca Viviana , Sorbo Sergio , Di Napoli Michela , Varcamonti Mario , Basile Adriana , Rigano Daniela
Published: August 2018

Heat stress affects the yield of medicinal plants and can reduce biomass and/or metabolite production. In order to evaluate the effect of heat-induced stress on the essential oil production in Mentha x piperita L. var. Mitcham (Mitcham mint) and Mentha x arvensis var. piperascens Malinv. ex L. H. Bailey (Japanese mint), we studied the chemical composition of the oils of the two mint species under different heat shock stress in growth chambers. The antibacterial activity of the essential oils was also evaluated; microscopic observation (fluorescence and electron transmission) was used to assess the effect of the tested samples on bacterial growth. The results obtained shed light on the mint essential oils composition and biological activity in relation to heat stress.
Orthographies in Grammar Books –Antiquity and Humanism
Authors: Stojanov Tomislav
Published: August 2018

This paper researches the as yet unstudied topic of orthographic content in antique, medieval, and Renaissance grammar books in European languages, as part of a wider research of the origin of orthographic standards in European languages. As a central place for teachings about language, grammar books contained orthographic instructions from the very beginning, and such practice continued also in later periods. Understanding the function, content, and orthographic forms in the past provides for a better description of the nature of the orthographic standard in the present. The evolution of grammatographic practice clearly shows the continuity of development of orthographic content from a constituent of grammar studies through the littera unit gradually to an independent unit, then into annexed orthographic sections, and later into separate orthographic manuals. 5 antique, 22 Latin, and 17 vernacular grammars were analyzed, describing 19 European languages. The research methodology is based on distinguishing orthographic content in the narrower sense (grapheme to meaning) from the broader sense (grapheme to phoneme). In this way, the function of orthographic description was established separately from the study of spelling. As for the traditional description of orthographic content in the broader sense in old grammar books, it is shown that orthographic content can also be studied within the grammatographic framework of a specific period, similar to the description of morphology or syntax. We found that 4 out of 5 antique, 11 out of 22 Latin and 5 out of 17 vernacular grammarians describe orthographic content in the narrower sense.
Preparation and Characterization of Esterified Bamboo Flour by an In Situ Solid Phase Method
Authors: Geng Yaqi , Pei Xiaohan , He Xiaoyu , Li Ping , Wu Yiqiang , Zuo Yingfeng
Published: August 2018

Bamboo plastic composites have become a hot research topic and a key focus of research. However, the many strong, polar, hydrophilic hydroxyl groups in bamboo flour (BF) results in poor interfacial compatibility between BF and hydrophobic polymers. Maleic anhydride-esterified (MAH-e-BF) and lactic acid-esterified bamboo flour (LA-e-BF) were prepared using an in situ solid-phase esterification method with BF as the raw material and maleic anhydride or lactic acid as the esterifying agent. Fourier transform infrared spectroscopy results confirmed that BF esterification with maleic anhydride and lactic acid was successful, with the esterification degrees of MAH-e-BF and LA-e-BF at 21.04 and 14.36%%, respectively. Esterified BF was characterized by scanning electron microscopy, contact angle testing, X-ray diffractometry, and thermogravimetric analysis. The results demonstrated that esterified BF surfaces were covered with graft polymer and the surface roughness and bonding degree of MAH-e-BF clearly larger than those of LA-e-BF. The hydrophobicity of esterified BF was significantly higher than BF and the hydrophobicity of MAH-e-BF better than LA-e-BF. The crystalline structure of esterified BF showed some damage, with MAH-e-BF exhibiting a greater decrease in crystallinity than LA-e-BF. Overall, the esterification reaction improved BF thermoplasticity, with the thermoplasticity of MAH-e-BF appearing better than LA-e-BF.
ZnO Nanoparticles Anchored on a N-Doped Graphene-Coated Separator for a High Performance Lithium/Sulfur Battery
Authors: Wang Suyu , Gao Fan , Ma Ruina , Du An , Tan Taizhe , Du Miao , Zhao Xue , Fan Yongzhe , Wen Ming
Published: August 2018

Fabrication of a nanocrystal zinc oxide (ZnO)/nitrogen-doped (N-doped) graphene composite using a novel and facile in situ sol-gel technique is demonstrated. Two-dimensional nanostructure morphology with uniform ZnO nanoparticles (average diameter of 10.25 nm) anchored on N-doped graphene nanosheets was observed via electron microscopy. Because of the polar heteroatoms on the graphene sheets, an abundance sites for polysulfide absorption were provided. More importantly, the strong chemical interaction between ZnO and polysulfides efficiently hindered the transport of polysulfides. Consequently, the lithium/sulfur (Li/S) battery with the ZnO/N-doped graphene composite-coated separator delivered enhanced performance in terms of discharge capacity and cycling stability when compared to the cell with a normal separator. With the modified separator, the battery achieved a discharge capacity as high as 942 mAh g-1 for the first cycle and remained at 90.02 mAh g-1 after the 100th charge/discharge test at 0.1 C. Results indicate that impeding the shuttling of polysulfides contributes to efficiently improving the behavior of the Li/S battery.
The Creep-Damage Model of Salt Rock Based on Fractional Derivative
Authors: Zhou Hongwei , Liu Di , Lei Gang , Xue Dongjie , Zhao Yang
Published: August 2018

The use of salt rock for underground radioactive waste disposal facilities requires a comprehensive analysis of creep-damage process in salt rock. A computer-controlled creep setup is employed to carry out a creep test of salt rock lasted as long as 359 days under a constant uniaxial stress. The AE space-time evolution and energy releasing characteristics during creep test are studied in the meantime. A new creep-damage model is proposed on the basis of fractional derivative by combining the AE statistical regularity. It indicates that the AE data in non-decay creep process of salt rock can be divided into three stages. Furthermore, the parameters of new creep-damage model are determined by Quasi-Newton method. The fitting analysis suggests that the creep-damage model based on fractional derivative in this paper provides a precise description of full creep regions in salt rock.
Long Sleep Duration and Social Jetlag are Associated Inversely with a Healthy Dietary Pattern in Adults: Results from the UK National Diet and Nutrition Survey Rolling Programme Y1-4
Authors: Almoosawi Suzana , Palla Luigi , walshe Ian , Vingeliene Snieguole , Ellis Jason
Published: August 2018

Limited observational studies have described the relationship between sleep duration and overall diet. The present study investigated the association between sleep duration at weekdays and empirically derived dietary patterns in a nationally representative sample of UK adults, aged 19-64 years old, participating in the 2008-2012 UK National Diet and Nutrition Survey Rolling Programme. Survey members completed between three to four days of dietary records. Sleep duration at weekdays was categorised into tertiles to reflect short, normal and long sleep duration. Social jetlag was calculated as the difference between sleep duration at weekends and weekdays. The association between sleep duration/ social jetlag and dietary patterns, derived by principal components analysis, was assessed regressing diet on sleep whilst accounting for the complex survey design and adjusting for relevant confounders. Survey members in the highest tertile of sleep duration had on average 0.45 (95% CI -0.78, -0.12) lower healthy dietary pattern score compared to middle tertile (p =0.007). There was an inverted u-shaped association between social jetlag and a healthy dietary pattern, such that when sleep at weekends exceeded weekday sleep by 1h 45min, scores for indicating a healthy dietary pattern declined (p =0.005). In conclusion, long sleep duration at weekdays and an increased social jetlag are associated with a lower healthy dietary pattern score. Further research is required to address factors influencing dietary patterns in long sleepers.
Low-temperature electrocatalytic conversion of CO2 to liquid fuels: effect of the Cu particle size
Authors: De Lucas-Consuegra Antonio , Serrano-Ruiz Juan Carlos , Gutierrez-Guerra Nuria , Valverde José Luis
Published: August 2018

A novel gas-phase electrocatalytic system based on a low-temperature proton exchange membrane (Sterion) was developed for the gas phase electrocatalytic conversion of CO2 to liquid fuels. This system achieved gas-phase electrocatalytic reduction of CO2 at low temperatures (below 90 ºC) over a Cu cathode by using water electrolysis-derived protons generated in-situ on an IrO2 anode. Three Cu-based cathodes with varying metal particle sizes were prepared by supporting this metal on an activated carbon at three loadings (50, 20, and 10 wt%; 50%Cu-AC, 20%Cu-AC, and 10%Cu-AC, respectively). The cathodes were characterized by N2 adsorption–desorption, temperature-programmed reduction (TPR), and X-ray diffraction (XRD) whereas their performance towards the electrocatalytic conversion of CO2 was subsequently studied. The membrane electrode assembly (MEA) containing the cathode with the largest Cu particle size (50%Cu-AC, 40 nm) showed the highest CO2 electrocatalytic activity per mole of Cu, with methyl formate being the main product. This higher electrocatalytic activity was attributed to the lower Cu–CO bonding strength over large Cu particles. Different product distributions were obtained over 20%Cu-AC and 10%Cu-AC, with acetaldehyde and methanol being the main reaction products, respectively. The CO2 consumption rate increased with the applied current and the reaction temperature.
Failure Modes, Effects and Criticality Analysis for Wind Turbines Considering Climatic Regions and Comparing Geared and Direct Drive Wind Turbines
Authors: Ozturk Samet , Fthenakis Vasilis , Faulstich Stefan
Published: August 2018

The wind industry is looking for ways to accurately predict the reliability and availability of newly installed wind turbines. Failure modes, effects and criticality analysis (FMECA) is a technique utilized for determining the critical subsystems of wind turbines. There are several studies which applied FMECA for wind turbines in the literature, but no studies so far have considered different weather conditions or climatic regions. Furthermore, various design types of wind turbines have been analyzed applying FMECA but no study so far has applied FMECA to compare the reliability of geared and direct-drive wind turbines. We propose to fill these gaps by using Koppen-Geiger climatic regions and two different turbine models of direct-drive and geared-drive concepts. A case study is applied on German wind farms utilizing the WMEP database which contains wind turbine failure data from 1989 to 2008. This proposed methodology increases the accuracy of reliability and availability predictions and compares different wind turbine design types and eliminates underestimation of impacts of different weather conditions.
A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures
Authors: Anil Kumar Shweta , Tasnim Nishat , Dominguez Erick , Allen Shane C. , Suggs Laura , Ito Yoshihiro , Joddar Binata
Published: August 2018

3D bioprinting holds great promise in the field of regenerative medicine as it can create complex structures in a layer-by-layer manner using cell-laden bioinks, making it possible to imitate native tissues. Current bioinks lack both the high printability and the biocompatibility required in this respect. Hence, the development of bioinks that are capable of both properties is needed. In our previous study, a furfuryl-gelatin based bioink, crosslinkable by visible light, was used for creating mouse mesenchymal stem cell-laden structures with high fidelity. In this study, lattice mesh geometries were printed in a comparative study to test against the properties of a traditional rectangular-sheet. After 3D printing and crosslinking, both structures were analysed for swelling and rheological properties, and their porosity estimated using scanning electron microscopy. Results showed that the lattice structure was relatively more porous but sturdy and exhibited a lower degradation rate compared to the rectangular-sheet. Further, the lattice allowed encapsulation of a greater number of cells, allowing them to proliferate to a greater extent compared to the rectangular-sheet that retained a lesser number of cells initially. All of these results collectively affirmed that the lattice poses as a superior scaffold design for tissue engineering applications.
Synthesis of 1,5-Functionalized 1,2,3-Triazoles Using Ionic Liquid/Iron(III) Chloride as Efficient and Reusable Homogeneous Catalyst
Authors: De Nino Antonio , Merino Pedro , Algieri Vincenzo , Nardi Monica , Di Gioia Maria Luisa , Russo Beatrice , Tallarida Matteo, Antonio , Maiuolo Loredana
Published: August 2018

An efficient, eco-compatible and very cheap method for the construction of triazoles via eliminative azide–olefin cycloaddition (EAOC) reaction has been developed by a catalytic system IL/FeCl3, offering an highly regioselective approach to structurally diverse 1,5-disubstituted 1,2,3-triazoles in up to 95% yield. This strategy features the reuse of catalytic system through simple operations. Mechanistic studies indicated that an asynchronous concerted dipolar cycloaddition-elimination process might be involved.
Design and Development of Weatherproof Seals for Prefabricated Construction: A Methodological Approach
Authors: Orlowski Kristopher , Shanaka Kasun , Mendis Priyan
Published: August 2018

Satisfactory weatherproofing of buildings is vital to maximise their design life and performance which requires the careful design of external sealing technologies. Systems commonly available have served well in conventional construction however with many prefabricated systems emerging in the building industry new and novel means of weatherproofing between panels and modules need to be developed purpose specific to this application. This paper presents a holistic and fundamental methodological approach to Design and Development of waterproof seals and has been applied specific for prefabricated panelised and modular systems. Two purpose specific weatherproof seals are finally presented. Flow charts of the overview of the suggested methodological approach and the processes within which include DfMA that have been incorporated into understanding and developing seals for this practical application. These strategies have enabled a resourceful and holistic set of processes that can be adapted and used for similar forms of product research in new and developing areas of construction such as prefabrication. The design and development process is thoroughly explored and has resulted in an exploration of the technical challenges and potential solutions which take into consideration factors from installation limitations to building tolerances.
Potentiality and Limitations of Open Satellite Data for Flood Mapping
Authors: Notti Davide , Giordan Daniele , Calò Fabiana , Pepe Antonio , Zucca Francesco , Galve Jorge Pedro
Published: August 2018

Satellite remote sensing is a powerful tool to map flooded areas. In the last years, the availability of free satellite data sensibly increased in terms of type and frequency, allowing producing flood maps at low cost around the World. In this work, we propose a semi-automatic method for flood mapping, based only on free satellite images and open-source software. As case studies, we selected three flood events recently occurred in Spain and Italy. Multispectral satellite data acquired by MODIS, Proba-V, Landsat, Sentinel-2 and SAR data collected by Sentinel-1 were used to detect flooded areas using different methodologies (e.g., MNDWI; SAR backscattering variation; Supervised classification). Then, we improved and manually refined the automatic mapping using free ancillary data like DEM based water depth model and available ground truth data. For the areas affected by major floods, we also validated and compared the produced flood maps with official maps made by river authorities. We calculated flood detection performance (flood ratio) for the different datasets we used. The results show that it is necessary to take into account different factors for the choice of best satellite data, among these, the time of satellite pass with respect to the flood peak is the most important one. SAR data showed good results only for co-flood acquisitions, whereas multispectral images allowed detecting flooded areas also with the post-flood acquisition. With the support of ancillary data, it was possible to produce reliable geomorphological based flood maps in the study areas.
Cationic High Molecular Weight Lignin Polymer: A Flocculant for the Removal of Anionic Azo-Dyes from Simulated Wastewater
Authors: Wang Shoujuan , Kong Fangong , Fatehi Pedram , Hou Qingxi
Published: August 2018

The presence of dyes in wastewater effluents made from the textile industry is a major environmental problem due to their complex structure and poor biodegradability. In this study, a cationic lignin polymer was synthesized via the free radical polymerization of lignin with [2- (methacryloyloxy) ethyl] trimethylammonium chloride (METAC) and used to remove anionic azo-dyes (reactive black 5, RB5, and reactive orange 16, RO16) from simulated wastewater. The effects of pH, salt and concentration of dyes, well as the charge density and molecular weight of lignin-METAC polymer on dye removal were examined. Results demonstrated that lignin-METAC was an effective flocculant for the removal of dye via charge neutralization and bridging mechanisms. The dye removal efficiency of lignin-METAC polymer was independent of pH. The dosage of the lignin polymer required for reaching the maximum removal had a linear relationship with the dye concentration. The presence of inorganic salts including NaCl, NaNO3 and Na2SO4 had marginal effect on the dye removal. Under the optimized conditions, greater than 98 % of RB5 and 94 % of RO16 were removed at lignin-METAC concentrations of 120 mg/L and 105 mg/L in the dye solutions, respectively.
Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals
Authors: Barth Bradley , Huang Hsin-I , Hammer Gianna , Shen Xiling
Published: August 2018

Advanced electrode designs have made single-unit neural recordings commonplace among modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges.
Vertex Labeling and Routing for Farey-Type Symmetrically-Structured Graphs
Authors: Jiang Wenchao , Zhai Yinhu , Zhuang Zhigang , Martin Paul , Zhao Zhiming , Liu Jia-Bao
Published: August 2018

The generalization of Farey graphs and extended Farey graphs are all originated from Farey graph and scale-free and small-world simultaneously. We propose a labeling of the vertices for it that allows determining all the shortest paths routing between any two vertices only based on their labels. The maximum number of shortest paths between any two vertices is huge as the product of two Fibonacci numbers, however, the label-based routing algorithm runs in linear time O(n). The existence of an efficient routing protocol for Farey-type models should help the understanding of several physical dynamic processes on it.
Metal Removal from Acid Waters by an Endemic Microalga from the Atacama Desert for Water Recovery
Authors: Martínez Marcela , Leyton Yanett , Cisternas Luis A. , Riquelme Carlos
Published: August 2018

The environmental problems generated by waste from the mining industry in the mineral extraction for business purposes are known worldwide. The aim of this work is to evaluate the microalga Muriellopsis sp. as a potential remover of metallic ions such as copper (Cu+2), zinc (Zn+2) and iron (Fe+2), pollutants of AMD type waters. For this, the removal of these ions was verified in artificial acid waters with high concentrations of the ions under examination. As well as, the removal was evaluated in waters obtained from areas contaminated by mining waste. The results showed that Muriellopsis sp. removed metals in waters with high concentrations after 4 to 12 hours and showed tolerance to pH between 3 to 5. These results allow proposing this species as a potential bioremediator for areas contaminated by mining activity. In this work, some potential alternatives for application in damaged areas are proposed as a decontamination plan and future prevention.
Limits of it-Soft Sets and Their Applications for Rough Sets
Authors: Xie Xiaoliang , He Jiali
Published: August 2018

Soft set theory is a mathematical tool for dealing with uncertainty. This paper investigates limits of interval type of soft sets (for short, it-soft sets). The concept of it-soft sets is first introduced. Then, limits of it-soft sets are proposed and their properties are obtained. Next, point-wise continuity of it-soft sets and continuous it-soft sets are discussed. Finally, an application for rough sets is given.
Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways
Authors: Fuellen Georg , Jansen Ludger , Cohen Alan A. , Luyten Walter , Gogol Manfred , Simm Andreas , Saul Nadine , Cirulli Francesca , Berry Alessandra , Antal Peter , Köhling Rüdiger , Möller Steffen
Published: August 2018

Despite increasing research efforts, there is a lack of consensus on defining aging or health. To understand the underlying processes, and to foster the development of targeted interventions towards increasing one’s health, there is an urgent need: (1) to find a broadly acceptable and useful definition of health, based on a list of features (which may or may not be molecular); (2) to operationalize features of health so that it can be measured; (3) to identify predictive biomarkers and (molecular) pathways of health, and (4) to suggest interventions, such as nutrition and exercise, targeted at putative causal pathways and processes. Based on a survey of the literature, we propose to define health as a state of an individual characterized by the core features of (a) physiological function, (b) cognitive function and (c) physical function, amended, specifically in case of humans, by (d) lack of disease, and by (e) reproductive function. Often used concepts such as lack of frailty, allostatic load, or self-reported health (in case of human), and indices such as the Healthy Aging Index can be viewed as projections or surrogates of our definition. We further define aging as the set of all processes in an individual that reduce its “wellbeing”, that is, its health or survival or both. We define biomarkers of health by their attribute of predicting future health better than chronological age. We define healthspan pathways as molecular features of health that relate to each other, specifically by belonging to the same molecular pathway. Our conceptual framework may integrate diverse operationalizations of health and guide precision prevention efforts that are a key to reducing the need for medical and nursing care.