bluuebunny/crossref_metadata_2025 huggingface dataset:
Erythrokeratodermia Progressiva Symmetrica: A Case Report from the Dermatology Hospital of Bamako
Authors: Guindo B , Kitha P , Keita A , Sangaré M , Kamaté P , Dembélé F. , Dissa L. , Dembele R. , Tounouga D , Diallo Z
Published: May 2024

Progressive erythrokeratodermia (PEK) is a rare génodermatose associated with disorders of keratinization. Mutations are found in genes encoding connexins 31 and 30.3 mapped to chromosome 1 p34-35. This disease is characterized by fixed hyperkeratotic plaques and transient erythematous plaques. Approximately 50% of affected individuals develop palmoplantar keratoderma. Connexins are components of gap junctions, which are intercellular channels present in almost all tissues, including the skin. A 15-year-old Guinean female, a seamstress, presented with asymptomatic black patches on her feet that had been evolving continuously for 5 years, initially starting on the feet and spreading elsewhere, gradually increasing in size with a transient tingling sensation. Previous treatment involved topical phytotherapy. She had no significant medical history, no similar skin conditions in the family, and no history of consanguinity between her parents. On examination, erythematous and keratotic plaques of variable shapes and sizes were noted on the backs of the hands, the posterior surfaces of the forearms, both knees, the lower thirds of the legs, and the backs of the feet, giving a sock-like appearance to the latter location. The complete blood count, lipid profile, and fasting blood glucose were normal. Histopathology was not performed. The diagnosis of progressive erythrokeratodermia of Gottron was considered based on the age of onset, clinical characteristics, and location of the lesions. The patient was prescribed topical keratolytics, oral Acitretin 10 mg, and psychotherapy for both the patient and her parents. It often constitutes an entity encountered in a syndromic context, highlighting the necessity for surveillance.
Radiation Therapy for Non-Melanoma Skin Cancer: A Study of 63 Cases
Authors: Oumayma Bounid , Rokkaya Iharti , Ghita Hadraoui , Youness El-khadir , Samir Barkich , Nezha Oumghar , Mouna Darfaoui , Abdelhamid El Omrani , Mouna Khouchani
Published: May 2024

Cutaneous carcinomas are the most common skin cancers. Our work aims to identify the epidemiological and clinicopathological characteristics of cutaneous carcinomas, especially squamous cell carcinomas and basal cell carcinomas, treated and monitored at the Oncoradiotherapy Department of the Mohammed VI University Hospital of MARRAKECH, treated with radiotherapy, and to evaluate their efficacy and tolerance. Our study is retrospective and descriptive. We collected data from 63 patients treated and monitored between 2019 and 2022 at the Marrakech University Oncohematology Hospital. For each patient, we collected epidemiological, clinicopathological, therapeutic, and evolutionary data using an exploitation form. The age of the patients ranged from 27 to 95 years, with a peak between 61 and 70 years and a median of 64.32. Males predominated (74.6%). The matte skin phenotype was the most common, present in more than half of the patients. Among 63 patients surveyed, 69.8% had a history of prolonged sun exposure. Tumors of the head and neck were found in 65% of cases, with clinical appearance varying: 36.5% ulcerative-budding, 31.7% budding, 22.2% nodular, 6.4% sclerodermiform, and 3.2% ulcerated. Recurrences accounted for only 27% of consultations, and precancerous lesions were found in only 16% of patients. Most patients consulted at locally advanced stages (68.2%). Histologically, squamous cell carcinoma was confirmed in 63.5% of patients. External radiotherapy was performed in all patients, using three-dimensional conformal technique, adjuvant in 77.7% of cases, exclusive definitive in 19%, and palliative in 3.2% of cases. No patient received brachytherapy. Acute complications were observed in 52% of cases and late complications in 8%. After an average follow-up of 2 years, 76% of patients are still being followed in good disease control status with a complete response in 83% of them, 11% local recurrence, and 6% distant metastases. The incidence of cutaneous ........
Primary Renal Squamous Cell Carcinoma Incidentaly Discovred in a Non-Functioning Lithiasis Kidney: A Case Report
Authors: Benbiba S , Lahouaoui A , Dahami Z , Ganouni N Cherif-Idrissi -El , Fakhri Anas , Rais Hanane
Published: May 2024

Introduction: Primary squamous cell carcinoma of the kidney is a rare tumor with a poor prognosis. It often occurs on a lithiasis kidney. Observation: We report a case of a 62-year-old patient admitted for left back pain associated with lower urinary tract symptomes with fever. Clinical examination revealed tenderness of the left lumbar fossa. Radiological examinations showed left ureterohydronephrosis, with the presence of a left kidney stone. A left radical nephrectomy was performed showing the presence of a neoplasm measuring 7cm with on histological examination a moderately differentiated and infiltrating squamous cell carcinoma. Conclusion: The diagnosis of squamous cell carcinoma of the kidney must be evoked in the first place in front of any renal mass with notion of kidney stones.
Pembrolizumab-Induced Pancytopenia: A Case Report
Authors: Lamsyah O. , Lkhoyaali S. , Harrak Y. Al , Kouanga A. , Boutayeb S. , ER-Rihani H. , Badrane N. , Bencheikh R. Soulaymani
Published: May 2024

Introduction: Immunotherapy is increasingly acknowledged as an effective treatment for metastatic melanoma. Hematological immune-mediated adverse events are rarely reported. In this article, we report a case of a patient who developed pancytopenia following administration of pembrolizumab. Case Report: A 63 -year-old woman, followed for a scalp melanoma with pulmonary metastasis developed severe pancytopenia after receiving 4 cycles of pembrolizumab. Outcome and Management: Following the appearance of the adverse effect, Pembrolizumab was stopped. A series of blood tests were performed in order to get the reasons of this event. The patient received high-dose of corticosteroids with tapering the dose over 6 weeks, and blood transfusion was required. Discussion: Checkpoint inhibitors (ICI) stimulate both humoral and cellular immune responses against tumor antigens, potentially resulting in immune-related adverse effects, including hematological issues like pancytopenia. Due to the substantial morbidity and mortality linked to ICI-induced pancytopenia, further data is essential to formulate evidence-based management guidelines.
Orbital Cellulitis in a Neonate: A Case Report
Authors: Laanait Radia , Lahmini Widad , Bourrous Mounir
Published: May 2024

Orbital cellulitis is a serious, yet uncommon infection in neonates. It can result in significant sight and life-threatening complications. Most commonly, it occurs secondarily as the result of a spread of infection from the sinuses or most likely from bacteremia. We hereby report a case of orbital cellulitis secondary to Staphylococcus aureus bacteremia. In a 15 day old neonate.
Invasive Ductal Carcinoma with Choroidal Metastases
Authors: Raboua M. , billah A. El Moutaalik , Elhajjami Y. Bouktib , Boutaqiout B. , Ouali M. Idrissi , Ganouni N. Cherif Idrissi
Published: May 2024

Choroidal metastases, along with choroidal melanoma, are common ocular malignancies. We report a case of a 47-year-old woman with metastatic breast carcinoma to the bone and lung, undergoing chemotherapy, who presented with a rapidly declining visual acuity in her right eye. The diagnosis of right unilateral choroidal metastasis was confirmed using fluorescein angiography, ocular ultrasound, and magnetic resonance imaging. Choroidal metastases typically manifest in advanced stages of disseminated disease and have a poor prognosis. Early detection and appropriate management are crucial for these patients. The treatment approach remains palliative, focusing on systemic disease control and preserving vision when possible.
Why is Clive Bell, an Artist with no Training in Logic, Mathematics, Statistics or Probability, being cited as an Expert on J M Keynes’s A Treatise on Probability?
Authors: Adjunct Michael Emmett Brady
Published: May 2024

Ramsey’s criticism, that “… the obvious one is that there really do not seem to be any such things as the probability relations he describes”, ignored Keynes’s analysis, for example, on page 36 of the A Treatise on Probability that required the propositions linking the premises and conclusion had to be similar. Ramsey ignored the fact that Keynes’s method was based on using Boole’s relational, propositional logic that required that the propositions had to be connected, related or similar before the formal, mathematical, symbolic logic could be applied. Keynes pointed out that the “…analogy between orders of similarity and probability is so great that its apprehension will greatly assist that of the ideas I wish to convey” (Keynes, 1921, p.36; italics added). Ramsay failed to grasp Keynes’s analogy between similarity and probability before criticizing Keynes. Ramsey’s main example of supposed errors in Keynes’s analysis relies on examples, such as his “My carpet is green, Napoleon was a great general “(Ramsey, 1922, p.3), which involves dissimilar and unrelated propositions which are not connected. Keynes’s introductory comments on p.36 were then explored in Part III of the A Treatise on Probability in far greater depth and detail by Keynes. Keynes’s objective, probability relations are simply objective relations connecting old, known situations with new situations that can be shown to be related. Human pattern recognition skills involve using resemblance functions based on past memory that projects past knowledge of old situations into new situations, where there are similarities that are seen to exist between the old, known situation and a new, unexplored situation. One then can come up with a rational degree of belief regarding how some new situation will play out, given the similarities that exist between the old and new situations. All of Ramsey’s examples attacking Keynes’s theory involve examples such as the green carpet -Napoleon example above. Herbert ......
Interest of Locoregional Analgesia for the Management of Pulmonary and Hepatic Hydatid Cyst Disease
Authors: M Matouk, , F Chettibi,
Published: May 2024

Introduction: Pulmonary and hepatic hydatid disease requires complex management. Analgesia is a key element. Objective: Assess the interest of epidural and paravertebral analgesia. Methods: Retrospective study of 8 patients undergoing surgery for pulmonary and hepatic cysts under locoregional analgesia. Comparison of pain scores, hemodynamic and respiratory stability. Results: Effective analgesia observed without instability. One allergic complication noted. Conclusion: These techniques seem interesting in this context. Comparative studies are needed.
Breast Paget Disease: A Rare Cancer in Dermatology
Authors: Diané Boh Fanta , Bah Ibrahima Koussy , Kanté Mamadou Diouldé , Diallo Abdoulaye Sadio , Fofana Kadé , Barry Mamadou Aliou Babemba , Tounkara Thierno Mamadou
Published: May 2024

Paget's disease (PD) of the breast is a rare disease of the nipple-areola complex often associated with underlying carcinoma, accounting for less than 4% of all breast carcinomas. We report a case of Paget's disease remarkable for its rarity, the diagnostic delay and the relatively young age of our patient in the Dermatology department of the Donka National Hospital. A 38-year-old woman consulted for itching of the left nipple associated with an oozing erythematous-squamous plaque and tumor-like left axillary lymphadenopathy evolving since4 years. Clinical examination and histopathology confirmed breast Paget's disease. A left mastectomy with lymph node dissection was performed, supplemented by chemotherapy. The evolution was good with absence of recurrence and metastasis after a follow-up of 16 months. Paget's disease corresponds to the invasion of the nipple epidermis by ductal carcinoma in situ (CIS), a rare variant of CIS. Classically, it develops between the ages of 51 and 70, however cases of Paget's disease of the nipple in young women during periods of genital activity have been reported in the literature as illustrated by our observation. The diagnosis of PD is often made late. An easy biopsy should be offered for all unilateral eczematous lesions of the nipple to compensate for this diagnostic delay. Mastectomy or breast-conserving surgery is often recommended. Adjuvant treatments are discussed on a case-by-case basis.
Moderation of Organizational Justice on the Influence of Leader-Member Exchange and Discipline on the Performance of ASN Employee
Authors: Lukiyana Lukiyana , Wansesa Fitri Nurjati
Published: May 2024

Moderation of organizational fairness and leader-member exchange are important variables that can influence employee performance. This research aims to test and analyze the moderation of organizational justice on the influence of member-leader exchange on the performance of ASN employees of the Ministry of Maritime Affairs and Fisheries. population in this study used a sample of 82 respondents who were employees of the Ministry of Maritime Affairs and Fisheries. The data collection technique uses simple random sampling by distributing research questionnaires in the form of Google Forms via social media. The data processing method in this study is to use smartPLS version 4 to test the hypothesis. The results of this study indicate that leader-member exchange is proven to have a positive and significant effect on employee performance, discipline performance is proven to have a positive and significant effect on employee performance, and organizational justice is proven to affect employee performance. Moderation of Organizational Justice weakens but is significant for the effect of leader-member exchange on performance. Organizational justice strengthens and can moderate Discipline performance on employee performance.
Analysis of Physical Evidence and Promotion of Braga Tourism Village on the Interest in Visiting Tourists
Authors: Oktaviani Desy , Sukma Andhi , Latifah Ifa , Al Hafidz Salma Nur
Published: May 2024

Interest in visiting is an encouragement that arises from within each individual to visit a tourist attraction. Interest in visiting tourists to a tourist attraction is influenced by several factors such as physical evidence and promotions carried out by the manager. If the value of physical evidence and promotional activities is increased, then tourist visits will also increase to a tourist attraction. This study aims to determine the effect of physical evidence and promotion on Tourist Interest in Braga Tourism Village in Bandung City. This study uses quantitative methods with descriptive analysis and verification approaches. The population of this study were prospective tourists who would visit the city of Bandung. The data that has been collected and obtained from the results of this study was then calculated using the SPSS ver. 25 application. 25. From the results of this test, it can be concluded that physical evidence has a significance value of 0.038 less than 0.05 so it can be concluded that it has a positive and significant influence on visiting interest. Promotion also has a significance value of 0.000 less than 0.05 so it can be concluded that the promotion variable has a significant effect on tourist interest.
The Influence of GCG on Disclosure of ESG Scores of Companies Listed on the IDX
Authors: Marheni Dewi Khornida , Erick Erick , Ramadani Arienda Gitty , Wandi Yulfis
Published: May 2024

A sustainability report became one of the requirements for corporations to publish as one of the key factors of why the investor wants to invest in the corporation. In Indonesia, there is a regulation for corporations to implement sustainability. Along with good corporate governance, generated a good sustainability report. In Indonesia, approximately about 55% of the companies have published sustainability reports. Hence, this research is purposed to know the influence of good corporate governance in sustainability reports in Indonesia. This research uses a quantitative research design to collect numerical data to test the hypothesis. In this research, 54 companies listed on the IDX that had published sustainability reports for 5 consecutive years were used. In addition, the study collected secondary data from the selected companies' annual, financial, and sustainability news from 2017 to 2021. The results of this research indicate that board independence significantly affects the disclosure of the ESG Scores of companies included in the IDX index. As a result, the board independence of companies in Indonesia is one of the components that help improve ESG Scores' disclosures.
Increase in Profit Based on Internal Capital and Business Volume in Cooperatives in Indonesia
Authors: Azhari Azhari
Published: May 2024

The cooperatives in Indonesia have hundreds of thousands, but not all are active due to several factors, including member participation, revenue, assets, and external capital. The purpose of this study is to provide the dominant factors that affect the operating profit of cooperatives. This research is quantitative causality, with data from 2001-2021 and multiple regression as an analysis tool. The data source was obtained from the Ministry of Cooperatives and SMEs. The analysis results show that the variables of own capital and sales volume simultaneously affect the remaining operating results, while partially owned capital does not affect cooperative profits. This research can evaluate increasing cooperative profits through policies that can be applied to cooperatives.
The Influence of Creativity and Innovation on Competitive Advantage and Price as a Mediating Variable
Authors: Febrianti R Adjeng Mariana
Published: May 2024

The rapid growth of the creative economy has garnered significant attention from the government. The Kelom Geulis industry evolved its designs, incorporating airbrush and batik elements. Despite achieving recognition nationally and internationally, artisans struggled to diversify their designs, sustain innovation, adapt to changing consumer preferences, and standardize pricing. This research investigates the influence of creativity and innovation on competitive advantage through price within the Kelom Geulis Creative Industry in Gobras Village, Tasikmalaya City. An explanatory research approach was employed to elucidate causal relationships among variables through hypothesis testing. The study used Structural Equation Modeling (SEM) and Partial Least Squares (PLS) analysis to analyze the data. Data was collected from a purposive sample of 200 customers who purchased Kelom Geulis products. The findings demonstrate that creativity (t = 3.071, p = 0.002) significantly influences competitive advantage. Similarly, innovation (t = 8.177, p = 0.000) significantly affects competitive advantage. Additionally, price (t = 4.268, p = 0.000) plays a substantial role in shaping competitive advantage. Indirectly, creativity significantly influences competitive advantage through price (t = 2.299, p = 0.022), while innovation also significantly influences competitive advantage and Price as a mediating variable (t = 3.403, p = 0.000).
Adaptation of Transcendence at Work Measuring Instruments for Muslim Employees
Authors: Cahyono Aryo Bima Fathoni , Kanya Nita , Kadiyono Anissa Lestari
Published: May 2024

Transcendence in the workplace is an individual's sense of connectedness to colleagues and the larger community through the perception of work as a service for the common good that generates a sense of completeness and fulfillment. To analyze it, a measuring instrument is needed that can measure this. This study aims to adapt transcendence at work measuring instruments and test the psychometric properties to be tested on Muslim workers in Indonesia. This measuring instrument has been confirmed suitable for use in Hindu workers in India, but there have been no studies that test this measuring instrument on Muslim workers. The concept of transcendence which is quite attached to the teachings of Islam makes researchers interested in conducting this research. The transcendence at work measuring instrument developed by Khari and Sinha consists of 3 dimensions and 12 items that can measure transcendence in the workplace. The process of adapting measuring instruments refers to the International Test Commission. This study involved 200 Muslim workers in Indonesia.  The reliability tests used are alpha Cronbach and CFA to measure construct validity. It was found that all items in the transcendence at work measuring instrument can measure transcendence in the workplace in Muslim workers in Indonesia.
Maus tratos a animais e teoria do elo
Authors: Rufino Pedro Henrique Quessada , Sousa Fábio dos Santos , Belettini Salviano Tramontim , Dissenha Adriely , Boscarato André Giarola , Paula Dalila Soares de , Rosina Leonardo Matheus Jagelski , Leitzke Arthur Venicius Sbaraini , Borges Talita Bianchin , Broch Natália Regina Alexandrino , Sá Thaís Camaso de , Quessada Ana Maria
Published: May 2024

A presente revisão tem o objetivo de realizar um levantamento na literatura sobre a associação entre os crimes contra animais e os crimes contra pessoas. Para isso, foi realizada uma busca em sites científicos utilizando-se termos relacionados ao tema. Por meio da análise dos artigos resgatados registrou-se que os maus-tratos aos animais fazem parte da realidade de todas as populações. Porém, é preciso dar atenção à crueldade contra os animais, já que, segundo a Teoria do Elo, a violência pode se estender para outros crimes. Estudos mostram que casos de violência animal perpetuados por pessoas ocorrem antes de realizarem crimes mais bárbaros contras seres humanos. Estima-se que os abusadores de animais têm cinco vezes mais probabilidade do que os não abusadores de cometer crimes violentos contra pessoas, quatro vezes mais probabilidade de realizar delitos contra a propriedade e três vezes mais probabilidade de ter um registro de delitos de drogas. Todavia a maioria dos crimes contra animais é ignorada por falta de notificação. Um aspecto importante é que o médico veterinário pode identificar casos de abusos contra animais, tornando-se o elo comunicante desses crimes às autoridades, consequentemente, contribuindo com a prevenção de violência futura contra animais e até mesmo contra pessoas. Conclui-se que os maus tratos a animais são sentinela para violência contra seres humanos. Desta forma, profissionais da lei e da saúde devem encarar a crueldade contra animais como um problema de segurança pública.
Comorbidades psiquiátricas em pacientes com queixas gastrointestinais: relato de caso sobre a importância da medicina centrada na pessoa
Authors: Goldman Ruwel Andressa , Boeira Duarte Victoria , Céspedes Gurski Flávia , Ferreira da Silva Gabriel , Kroeff Schmitz Gibk Cristina , Castagna Wortmann André
Published: May 2024

Introdução: condições psiquiátricas em pacientes com queixas gastrointestinais representam um desafio clínico complexo, exigindo uma abordagem integral das questões de saúde, tanto psíquicas quanto físicas. Objetivo: relatar a presença de comorbidades psiquiátricas em pacientes com queixas gastrointestinais e enfatizar a importância da abordagem baseada no modelo biopsicossocial, tanto na assistência ao paciente quanto na educação médica. Método: relato de experiência construído acerca da história de um caso conduzido por estudantes do oitavo semestre de Medicina em uma clínica de Gastroenterologia. Resultado e conclusão: é necessário a prática de uma abordagem multidisciplinar na medicina, ainda mais para pacientes com queixas gastrointestinais, pois tais sintomas estão presentes diversas vezes com questões psiquiátricas. Isso ressalta a importância da formação médica com a prática da medicina centrada na pessoa.
Tingkat Pengetahuan dan Sikap Pasien terhadap Swamedikasi Pemilihan Obat Tradisional dan Konvensional di Apotek Dharma Medika Badung
Authors: Susianti Luh , Megawati Fitria , Agus Adrianta Ketut
Published: May 2024

Menurut World Health Organization (WHO) swamedikasi merupakan tindakan memilih dan menggunakan obat modern, obat herbal, obat tradisional oleh diri sendiri untuk mengurangi atau mengatasi suatu penyakit atau gejala penyakit. Dalam pelaksanaan swamedikasi tidak lepas dari penggunaan obat tradisional dan obat konvensional, dimana prefrensi terhadap pemilihan obat sangat dipengaruhi oleh faktor pengetahuan dan sikap. Adapun tujuan dari penelitian ini yakni mengetahui tingkat pengetahuan dan sikap terhadap pemilihan obat tradisional dan konvensional dalam melakukan swamedikasi pada pasien di Apotek Dharma Medika Badung.Rancangan penelitian yang digunakan adalah cross sectional dan teknik pengambilan sampel dilakukan dengan metode accidental sampling sebanyak 68 responden yang sesuai dengan kriteria inklusi dan eksklusi. Instrumen dalam penelitian ini adalah kuesioner tertutup dengan 14 pertanyaan, dimana kuesioner tersebut terlebih dahulu telah diuji validitas dan reliabilitasnya oleh peneliti atas nama Ni Komang Pebri Antari Dewi untuk digunakan pada penelitian beliau sebelumnya di Apotek Sahabat Denpasar Timur.Hasil dari penelitian menunjukan tingkat pengetahuan responden dengan kriteria “Baik” sebesar 63%,kriteria “Cukup’ sebesar 28 %, “Kurang Baik” sebesar 6 %, dan “Tidak Baik” sebesar 3%. Sebagian besar pasien di Apotek Dharma Medika Badung memiliki tingkat pengetahuan yang baik dengan sikap responden yang cenderung positif terhadap obat konvensional dalam hal melakukan swamedikasi.
Effectiveness of bruxism treatment in young adults
Authors: Klitynska Oksana V. , Martyts Yurii M. , Gurando Viacheslav R. , Layoch Nataliya V.
Published: May 2024

Aim: This study aimed to assess the effectiveness of the developed algorithm for treatment and prevention measures aimed at eliminating clinical manifestations of bruxism in young people.
Materials and Methods: A cohort of 377 individuals aged 25 to 44 years underwent examination. Based on identified etiological factors, three distinct groups were delineated. Treatment and preventive strategies were then implemented and evaluated. Tailored treatment algorithms were devised for each group: Group one received selective grinding of supracontacts (up to 0.5-0.75 mm) and treatment for orthodontic issues utilizing removable and fixed orthodontic structures. Group two underwent finger self-massage of masticatory muscles, fabrication of biting dental splints, and anti-inflammatory drug therapy. Group three received sedative drug therapy in conjunction with psychiatric consultation, based on indications. Treatment efficacy was assessed 12 months post-initiation. Statistical analyses were conducted using Statistica 10.0 (StatSoft, Inc., USA) and Microsoft Office Excel 2010.
Results: In cases where orthodontic pathology and supracontacts predominated (r=0.99, p<0.05), employing selective grinding and orthodontic treatment according to specific indications yielded significant efficacy. This approach resulted in a notable reduction in bruxism severity, corroborated by occludogram results 12 months post-treatment initiation. Notably, 90.0% of occludogram indicators fell within the 90-100% range, accompanied by a decrease in the BruxChecker abrasion facets area (p<0.05). Further, there was a substantial enhancement in occlusal contacts (Ck=0.68, Ck =0.71, Ck =0.93). In instances where TMJ pathology predominated with high reliability (r=0.98, p<0.05), effective normalization of masticatory muscle tone and alleviation of temporomandibular joint issues were observed. After 12 months, palpation revealed minimal tenderness in specific muscle areas and normalization of electromyography readings from initial indicators (p<0.05). Moreover, when the psycho-emotional factor primarily contributed to bruxism etiology (r=0.97, p<0.05), medical intervention proved effective. This approach led to bruxism disappearance and normalization of the psycho-emotional state within 12 months (p<0.05).
Conclusions: The conducted studies provide high-confidence evidence of the effectiveness of bruxism treatment when diagnosing the prevailing etiological factor and targeting its specific impact, leading to the normalization of all other factors, a reduction in bruxism intensity, and its complete disappearance.
Cytological and microbiological investigations of professional hygiene efficiency in patients with generalized periodontitis
Authors: Ripetska Olha , Hrynovets Volodymyr , Deneha Ihor , Hrynovets Ihor , Potapchuk Anatoliy , Almashi Vasyl
Published: May 2024

Aim: The purpose of this study is to assess the impact of occupational hygiene procedures for microbiological and cytological contents of periodontal pockets.
Material and Methods: Cytological and microbiological content of the periodontal pockets before treatment and after professional hygiene procedures including scaling with hand instruments and root cementum polishing have been investigated in patients with periodontitis.
Results: According to obtained data it can be resumed that in periodontitis patients with the depth of pockets 3-5,5 mm before professional hygiene all the pockets contain great number of Cocci, Spirochetes, Candida Albicans, Flagellated rods and Protozoa species. It was proved by revealing of small amount of Polymorphonuclear leukocytes with active phagocytosis. After scaling and planing of the roots, a decrease in the number of Protozoa and Candida Albicans was observed in 97% and 72% of the investigated cells, respectively.
Conclusions: Cytological and microbiological content of periodontal pockets before treatment and after professional hygiene procedures including scaling and root planning testify to the level of local protective mechanisms, especially process of phagocytosis and virulence of microbial species in periodontal pockets.
Ocular lesions in patients with ulcerative colitis
Authors: Varvarynets Antonina V. , Beliayev Valerii D. , Hechko Mykhailo M. , Kurakh Artur V.
Published: May 2024

Aim: To analyze the data and evaluate the prevalence of ocular lesions in patients with moderate ulcerative colitis.
Materials and Methods: We observed 112 patients aged 18-75 years old with clinically, endoscopically and histologically confirmed moderate ulcerative colitis which lasted at least 6 months. An ophthalmologic exam was performed to determine the presence of ocular symptoms.
Results: Of the 112 patients with moderate ulcerative colitis, 21 (18,75%) had the following ocular lesions: episcleritis - 7 patients (6,25%), keratopathy – 5 patients (4,46%), uveitis - 5 patients (4,46%), cataract - 2 (1,78%) and scleritis - 2 (1.78%).
Conclusions: Because ocular symptoms in patients with UC are often nonspecific, it may be beneficial to perform ophthalmologic examinations as a routine follow-up component of in such patients.
Dynamic comparison the lower extremities length in students education in higher institutions
Authors: Karatieieva Svitlana Yu. , Slobodian Oleksandr M. , Moseychuk Yuriy Yu. , Muzyka Natalya Ya. , Slobodian Kseniya V. , Moroz Olena O.
Published: May 2024

Aim: Dynamic comparison of the lower limbs length, depending on the type of sport, followed by the construction of a mathematical model for predicting sports abilities.
Materials and Methods: The comparison of the lower limbs length in dynamics was carried out on 132 students of higher education institutions of Bukovyna. While the primary study was carried out during September-October 2021, next study of these same students was conducted in September-October 2022. The main group consists of 92 (69.7%) students, the control group - 40 (30.30%) students aged 16 to 18 years. All students underwent an anthropometric study (determination of the length of the lower limbs) according to the method of P.P. Shaparenka. The comparesment of anthropometric parameters in the main group depending on the type of sport used the Kruskel-Wallis test (non-parametric analysis of variance) in order to identify a reliable difference in the average indicators of the respondents depending on the type of sport (the median of the distribution was considered as a measure of central tendency). In order to establish which pairs of age groups had a statistical difference in the medians, the Conover-Iman test was used. A paired t-test (t-test of paired samples) was performed to compare the length of the respondents’ lower limbs during the first measurement and again one year later. Statistical analysis of the obtained data was performed using the licensed RStudio program.
Results: The distribution of the length of the right lower limb of the respondents of the main group by measurement shows that the average value of the length of the right lower limb has changed: a significant difference in the length of the right lower limb was found between the first (M = 88.812, SD = 5.287) and the second (M = 89.377, SD = 5.347) measurements; t (68) = -5.223, p < 0.001. The distribution of the length of the left lower limb shows that the average value of the length of the left lower limb has changed also: a significant difference in the length of the left lower limb was found between the first (M = 88.667, SD = 5.266) and the second (M = 89.435, SD = 5.309) measurements; t (68) = -8.289, p < 0.001.
Conclusions: In order to dynamically compare the length of the lower limbs for comprehensive control and selection of promising students in football, volleyball, handball and basketball, a mathematical model was derived for predicting the length of the lower limbs, in corresponding sports: right lower limb y = 0.506 x and left y = 0.507x, where y – is the length of the left lower limb, x – is the height. The coefficient of determination is 99.8%. A significant predictor for the length of both lower limbs is the height.
Constitutional and legal status of the subject during biomedical research
Authors: Pyroha Serhii S. , Shandra Bohdana B. , Naturkach Ruslana P. , Kohut Maryna G.
Published: May 2024

Aim: To find out the peculiarities of constitutional and legal status of the subject during biomedical research.
Materials and methods: A synergistic approach helps predict possible fluctuations and vectors of development, taking into account various social and technical processes of influence on the status of the subject; comprehensive - involves the analysis of the research subject within the framework of a combination of different scientific schools, concepts and methods and provides opportunities for the development of unified standards, benchmarks, principles and general norms of legal regulation.
Conclusions: The constitutional-legal status of the subject is the position of the subject (patient, object of research) established and established by the norms of constitutional law, which distinguishes him as a special subject of legal relations in the process of conducting biomedical research and consists of a set of rights and obligations and specifics of the legal liability of its participants.
Expanding the possibilities of using sodium-glucose cotransporter 2 inhibitors in patients with heart failure
Authors: Rоsul Мaryana М. , Bletskan Мyroslava М. , Ivano Nataliya V. , Rudakova Svitlana O.
Published: May 2024

Aim: To study the potential mechanisms of the beneficial cardiovascular effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, the possibilities of improving the treatment and prognosis of patients with acute heart failure (HF) during their use.
Materials and Methods: The data analysis of literary sources has been conducted regarding the results of existing studies evaluating the clinical benefit and safety of SGLT-2 inhibitors in patients with acute heart failure.
Conclusions: The peculiarities of the pharmacological action of SGLT-2 inhibitors and the obtained research results expand the possibilities of using this group of drugs, demonstrating encouraging prospects in improving the prognosis of patients hospitalized with acute heart failure.
PENGARUH BERKUMUR LARUTAN MADU HUTAN (APIS DORSATA) TERHADAP INDEKS PLAK PADA MAHASISWA TINGKAT 1 JURUSAN KESEHATAN GIGI POLTEKKES KEMENKES MANADO
Authors: I Ketut Harapan  , Mustapa Bidjuni
Published: May 2024

Plaque is a soft and sticky layer that sticks to teeth consisting of protein and bacteria. Removing plaque from the surface of the teeth is not only by brushing your teeth, but also by gargling with mouthwash that contains antibacterial substances. Honey is able to stop the development of bacteria in the mouth which causes a reduction in the plaque layer so that it can influence a decrease in the plaque index in a person's mouth. The aim of this research is to determine the effect of gargling forest honey solution (Apis Dorsata) on the plaque index in Level 1 Students of the Department of Dental Health, Health Polytechnic of the Ministry of Health Manado. This research method uses a tru experimental method to determine the influence between variables. This research was carried out on 19-23 May 2023 at the Department of Dental Health, Poltekkes, Ministry of Health, Manado. The total population is 51 people, and the sample is the total population. Sampling was determined based on inclusion and exclusion criteria. So the sample obtained in this research was 50 people. The data obtained was tabulated and analyzed using the paired sample t-test statistical test. And this research instrument uses a diagnostic tool and plaque index assessment format. The results of the study showed that the average before gargling with honey solution was 3.16 and after gargling with honey solution was 1.19, with a difference of 1.97. Based on analysis using the paired sample t-test, it shows that there is a significant difference seen from the p value = 0.000 (0.000 <0.05). This means that gargling with honey solution has an effect on reducing the plaque index.
ANALISIS KADAR SERUM GLUTAMIC PIRUVIC TRANSAMINASE DAN SERUM GLUTAMIC OXALOACETIC TRANSAMINASE PADA PASIEN TUBERKULOSIS YANG MENJALANI PENGOBATAN OBAT ANTI TUBERKULOSIS
Authors: Salbiah Salbiah , Diah Lestari  , Dina Indarsita  , Halimah Fitriani Pane  , Yasmine Amira Fadila
Published: May 2024

Introduction: Since 1995, Indonesia began to adopt the Directly Observed Treatment Shortcourse Chemotherapy (DOTS) system in controlling tuberculosis. The main drugs recommended in this system are Antituberculosis Drugs (OAT)  consisting of Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), and Ethambutol (E). The use of Anti-Tuberculosis Drugs can cause side effects which are still other problems, such as liver damage which is characterized by an increase in transaminase enzymes. Therefore, monitoring liver function is very important. The routine examination carried out is a serum transaminase examination, namely SGOT (AST) and SGPT (ALT). Therefore, monitoring liver function is very important. The routine examination carried out is a serum transaminase examination, namely SGOT (AST) and SGPT (ALT).
Objective: the aim of this study is to determine whether there is a difference between SGOT and SGPT levels before and after treatment with Antituberculosis Drugs . 
Method: The research design was cross-sectional analytic using secondary data from examination results of SGOT and SGPT levels from adult tuberculosis sufferers who were undergoing treatment at Cileungsi Regional Hospital, totaling 70 people. The research was conducted from January to August 2023.
Results: There was an increase in SGOT levels by 104%, namely from 21.61 IU/L before treatment to 43.47 IU/L and SGPT levels increased by 107%, namely from 16.41 IU/L before treatment to 34.47 IU /L.. The Wilcoxon test showed a significant difference of 0.000 (p <0.05) for SGOT and SGPT levels before and after treatment..
Conclusion: there is a significant difference between SGOT and SGPT levels before and after treatment with antituberculosis drugs.
Trust, Risk, and Dissonance: Prairie Agriculture and Canada’s Environmental Farm Plan
Authors:   , Harney Patrick
Published: May 2024

In the wake of combined economic and ecological pressure, Prairie farmers and the Canadian ministries responsible for agriculture are pressed to instigate sustainable agricultural development. However, Canada’s central agri-environmental program, the Environmental Farm Planning program (EFP), faces low uptake in the Prairie region. In this thesis, I explore the nature of the dissonance between the EFP and Prairie farmers to understand why participation is so low, the issues embedded in the EFP, and how to develop better agri-environmental policy for the Prairie region. I employ multiple methods, including survey, discourse, and institutional analyses, to make sense of the dissonance. Survey analysis is used to explore the social psychology of risk and characterize participant’s knowledge, risk perceptions, and trust regarding environmental action. Next, I employ discourse analysis to examine taken-for-granted notions embedded in how interviewees articulate their relationship to themselves, society, the environment, and the state. Finally, I utilize an institutional analysis to look at the mechanisms and values built into the EFP and the Prairie context and theorize how these institutional factors affect the EFP dissonance. Using the process of triangulation, I mix my methods to conclude that risk perceptions, economic constraints, and governmental trust are at the core of the EFP dissonance.
Operations and Supply Chain in Automobile Industry
Authors: - Rohit Juneja , - Prof. Dr. Vivek Aggarwal
Published: May 2024

Profitability, customer satisfaction, and innovation in the cutthroat automobile industry depend on well-managed operations and supply networks. Managing operations and supply chains in the automotive industry is complex, and this paper lays forth a comprehensive framework for doing so. An integral part of effective operations management in the automotive industry is demand forecasting and planning. Using collaborative forecasting methodologies, market trend analysis, and advanced analytics, automotive manufacturers can improve production schedules, minimize inventory costs, and foresee changes in demand. Reducing waste, enhancing process efficiency, and managing low inventory levels are all achieved through the use of lean manufacturing techniques like Just-in-Time (JIT) production and Total Productive Maintenance (TPM). Collaboration with suppliers, uninterrupted material flow, and supply chain innovation can all be achieved through supplier relationship management (SRM). Automakers may enhance product quality, cut costs, and lessen supply chain risks by communicating openly, working together to improve processes, and forming agreements that benefit all parties involved. Automobile companies can't afford to have any product flaws that damage their reputation or the loyalty of their customers, which is why quality management is so important in this industry. Statistical Process Control (SPC), Failure Mode and Effects Analysis (FMEA), and Six Sigma are a few of the rigorous quality control methods that manufacturers use to find and rectify flaws early. This helps them maintain high quality standards and meets client needs. Improving operational efficiency and lowering costs in the automotive supply chain are greatly aided by inventory management. By balancing inventory carrying costs and service levels, automotive manufacturers can improve supply chain agility and responsiveness through the use of advanced inventory optimization techniques such as ABC analysis, safety stock optimization, and demand-driven replenishment strategies.
Sleep Spindles using Electroencephalography signals
Authors: - Anchal Agrawal , - Raghavendra Prasad
Published: May 2024

EEG stands for electroencephalography. It is a non-invasive neurophysiological technique that and amplify the tiny electrical signals produced by neurons. A medical imaging method called electroencephalography measures the electrical activity in the scalp that is produced by brain regions (Teplan, 2002). Short oscillations known as sleep spindles can be seen in the human electroencephalogram (EEG) when a person is sleepy or drowsy (Lüthi, 2014). Neither the topography nor the morphology of sleep spindles remains constant throughout the lifespan (Clawson et al., 2016). Sleep spindles frequency range is between 12 Hz and 14 Hz. This frequency was extended to 11 Hz to 16 Hz after the American Academy of Sleep Medicine (AASM) published a new version of their sleep scoring guidelines in 2002 [37,16,15,43,23] One of the two primary sleep cycles that comprise a full sleep cycle is called NREM (Non-Rapid Eye Movement), the other being REM (Rapid Eye Movement) sleep. There are three stages of NREM sleep: N1, N2, and N3 (Al-Salman et al., 2019). With a sensitivity ranging from 89.1% to 100%, deep learning techniques have been developed to detect sleep spindles using 11 to 30 adult sleep EEGs
Implementation of the Anti-violence Against Women and Their Children Act of 2004 (RA 9262)
Authors: - JACQUELINE F. CASTILLO
Published: May 2024

The law RA 9262 otherwise known as Violence against Women and their Children Act of 2004 has been passed for almost a decade. The primary purpose is to value the dignity of women and children and to guarantee full respect for human rights.
Furthermore, it intended to assess the implementation of RA 9262 of Barangay Officials along the Operational Procedure in handling VAWC cases, Elimination of Anti-Violence against Women and their Children, Issuance of BPO’s, Confidentiality and Violation of a Barangay Protection Order. The researcher utilized the descriptive method, Frequency count, and percentage is used to determine the profile of the respondents. The mean rating is used to determine the extent of implementation. Simple Linear Correlation Analysis is used to determine the relationship between the perceived extent of implementation and the profile of the respondents.
The findings of the study on the profile of respondents were great majority of the respondents are married, male, and has been in the service for 0 – 1 year. Half of the respondents are college graduates, belong to the age bracket of 36 – 40 years and are barangay kagawad.
Results revealed that the extent of implementation on the duties and functions of barangay officials is “Implemented”. Furthermore, there is a significant relationship between the profile of the respondents and their perception on the extent of implementation of R.A. 9262. This is observed on civil status (r = .142) which is significant at .05 probability level and position (r = .206) which is significant at .01 probability level.
Recommendations to improve the implementation of RA 9262 are the following: a)Information dissemination on the operational procedure in handling VAWC cases to the residents of the Barangay, b)Seminar and information dissemination on the effects of Violence to the residents & implementers, c)E.O/Resolution for the creation of Counselling committee/ or Counsellor Seminar/Training programs for family accountability, d)Information Dissemination on RA 9262 for Barangay Official, e) Create more activities to solicit the women’s participation in the Barangay, f)Computer literacy and proper document technique, g)Conduct of Training /Seminar for Barangay Officials on their Duties and Functions, h)Training & seminar programs on proper keeping of documents & consequence of divulging such information, i)Allot budget for projects/Programs for the gender and development.
Recipe Recommendation System
Authors: - Abhishek Pandey , - Abhishek gupta , - Roshini Varma , - Bhanu tekwani
Published: May 2024

In the era of rapid urbanization and busy lifestyles, individuals often face the challenge of preparing meals with the limited ingredients available at home. To address this issue, we present a sophisticated Recipe Recommendation System based on ingredients, leveraging the power of Python, flask, and MongoDB. The
proposed system aims to revolutionize the way people approach cooking by providing personalized and efficient recipe suggestions tailored to the ingredients users already have. The proposed system employs advanced algorithms to match user-provided ingredients with a vast and diverse recipe database. By considering factors such as ingredient availability, the system
generates real-time, tailored recipe recommendations. The integration of machine learning techniques ensures accurate ingredient matching and enhances the system's ability to adapt to individual users' tastes and needs