bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of pore size and pore connectivity on trapped gas saturation
Authors: Dias Caroline H. , Eler Felipe M. , Cordeiro Carlos , Ramirez Mateus G. , Soares José A. , Nunes Denise , Lima Maira C.O. , Couto Paulo
Published: February 2023

Trapped or residual air (or gas) is known to affect the multiphase hydraulic properties of both soils and rocks. Trapped air is known to impact many vadose zone hydrologic applications such as infiltration and flow in the capillary fringe, but is also a major issue affecting recoverable oil reserves. Although many studies have focused on the relationship between porosity and trapped gas saturation (S

gt
) in sandstones, far fewer studies have been carried out for carbonate rocks. This work aims to analyze the influence of porous media properties on trapped gas saturation in carbonate rocks. For this we used thirteen Indiana Limestone and Silurian dolomite rock samples from the USA, and several coquinas from the Morro do Chaves formation in Brazil. Pore size distributions were obtained for all samples using Nuclear Magnetic Resonance (NMR), and Mercury Injection Capillary Pressure (MICP) data from three of the samples to determine their pore throat size distributions. Additionally, 3D microtomography (microCT) images were used to quantify macropore profiles and pore connectivities. Results indicate a lower capacity of gas trapping in carbonate rocks in which micro- and mesopores predominate. Results also indicate that in carbonate rocks, pore size exerts a greater influence on the ability of gas trapping compared to pore connectivity, so that rocks with a predominance of macropores have greater capacity for gas trapping, even when the macropores are well interconnected. These findings show that pore characteristics very much affect the processes governing gas trapping in carbonate rocks, and indirectly the multiphase hydraulic properties and recoverable oil reserves of carbonate rock reservoirs.
Effect of gravel content on soil water retention characteristics and thermal capacity of sandy and silty soils
Authors: Beck-Broichsitter Steffen , Rizvi Zarghaam Haider , Horn Rainer , Wuttke Frank
Published: February 2023

The presence of gravel in soils modifies the porosity, pore connectivity and pore size distribution in the soil matrix as well as the soil matrix-gravel interfaces. The aim of the present study is to investigate the effect of relative volume of gravel in samples with gravel mass fractions of 5,10, 20 wt% and varying bulk densities (1.3, 1.45, 1.55, 1.60, 1.65 g cm–3) on (i) total porosity, field capacity, plant available water holding capacity, (ii) pore size distribution and (iii) thermal capacity of repacked sandy and silty soils. The focus of the study was to determine if laboratory measured soil water retention curves considering (i), (ii), and (iii) can be predicted by a gravel-based weighting factor, Rv, considering comprehensive significance tests. The sand-gravel mixtures show a decrease in the volume fractions of macropores and wide cores pores with an increase in the gravel contents, while the silt-gravel mixtures show an opposite trend. The root mean square errors (RMSE) between measured and fitted volumetric water contents, θ, between 0.006 and 0.0352 and between 0.002 and 0.004 for Rv-weighted volumetric water contents indicate that the van Genuchten-based Peters-Durner-Iden (PDI) model is appropriate for fitting. The soil water retention curves with mass gravel contents of up to 10 wt% for silt and 20 wt% for sand can be well predicted by weighting factors (relative volume of rock fragments) in the range between 0.045 and 0.058 for silt, and between 0.112 and 0.119 for sand. The results also indicate a decrease in the Rv-weighted saturated, cvsat, and dry, cvdry, thermal capacity with an increase in the gravel contents for both soils. Further investigations are needed to examine if and whether measured sand- and silt-gravel mixtures with mass gravel contents below 10 % or rather 20 % can be predicted with a weighting factor.
Energy Transformation: Challenges and Opportunities — The Polish Case
Authors: Mitroczuk Igor J.
Published: February 2023

The article, meant as the first in a series, tries to answer some questions around the future desired shape of the new Polish electro-energy mix in relation to the one described in the national energy policy document PEP 2040 (Energy Policy of Poland till 2040) and as compared with the targets set up in the newest UE legislative package, ‘Fit-for-55’. In this article, I first present the rich overview of literature as well as economic theory behind the analysis of the energy transformation and energy-mix decarbonisation, in order to show how the energy mix should evolve in a way that will guarantee the biggest net gain to the society. Second, some comparable cost calculations on selected electro-energy sources, both LCOE (levelized cost of energy) and external costs are presented; these are modifications of my previous work as a co-author. Finally, the comparison of the 2040 electro-energy mix, as designed in the official governmental programme PEP 2040, with the two alternative scenarios, both of which exclude coal, and one also neglects the possibilities for nuclear energy to be included in the mix are presented. The alternative scenarios built into the paper are based on European Union (EU) plans to decarbonise Europe quickly. Recent geopolitical considerations related to the war in Ukraine, however, make it necessary to consider energy security as an important part of the plan. That would mean that nuclear energy would be a necessary component of the future mix in Poland. Security considerations are left to be analysed in the coming months, after a series of articles on lessons learnt by other developed countries in the process of making their energy-mix transformations and will complete the final recommendations for the future of the Polish energy mix.
Assessment of the phenotypic diversity of wild cherry (Prunus avium L.) populations and halfsib lines by multivariate statistical analyses
Authors: Neđić Milena Stanković , Župunski Milan , Orlović Saša , Kovačević Branislav , Kebert Marko , Vaštag Erna , Miljković Danijela , Gutalj Marko , Markić Anđelina Gavranović , Stojnić Srđan
Published: February 2023

Wild cherry (Prunus avium L.) is a multi-purpose tree species with great ecological and economic importance for European forestry. Evaluating this species phenotypic diversity and quantitative traits characterization is of great importance to define its genetic resources conservation and breeding strategies. In this work, variations of physiological, biochemical, anatomical and morphological traits of one-year-old wild cherry seedlings were evaluated within and among populations to distinguish and characterize their phenotypic portfolio. We observed significant differences at the intra- and inter-population levels considering both biochemical and physiological leaf traits, whereas differences in morphological and anatomical traits were found to be significant only among half-sib lines within populations (i.e. intra-population level). With a multivariate approach, we explored the inter-population specificity and found out that the tiered approach spanning from organ morphology, across physiological scale, to the biochemical level gave out enough power to discriminate between different populations, and their acquisition and resource-use strategies. Moreover, stepwise discriminative analysis showed that radical scavenger capacity against 2,2’-azino-bis(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS•+) and water-use efficiency contributed to discrimination of studied populations to the largest extend. Lastly, our study highlights the robustness of certain functional traits, such as ABTS•+, water-use efficiency, net photosynthesis, total flavonoid content, width of stomata guard cell, and stomatal aperture length, which could be considered as a proxy to discriminate between wild cherry populations and assess phenotypic diversity.
Evaluación del tiempo de infusión de una bebida funcional a base de hojas de culén y menta edulcorado con steviósido
Authors: Sosa-León José Luis , Martínez-Zurita Manuel
Published: February 2023

Las plantas de culén y menta tienen una gran importancia en el ámbito industrial y en la salud ya que estas hojas contienen propiedades aromáticas y curativas. Aunque en la actualidad existe poca información de esta materia prima con valor agregado. El presente estudio tuvo como objetivo general elaborar una infusión filtrante utilizando el método de deshidratación artificial a base de hojas de culén y menta edulcorado con steviósido. El estudio inició con la compra de medio kilo de stevia (granulada comercial) y con la recolección de 8 kg de materia prima (5 kg de culén y 3 kg de menta), las mismas que se sometieron a un análisis sensorial para determinar la aceptabilidad del color, aroma y estado de la materia prima. Luego, al obtener resultados aprobados por los 30 panelistas se inició con las actividades para el proceso de obtención del filtrante. El deshidratado se realizó con 2 niveles de temperatura (40 y 60 °C) por un tiempo de 7 horas y para las mezclas se utilizó 3 niveles de concentración (N1 = 50, 35 y 15 %; N2 = 45, 45 y 10 % y N3 = 45, 50 y 5 % con relación al culén, menta y stevia). Asimismo, la investigación contó con 2 variables cada una con sus respectivos niveles de estudio. Luego, para determinar el tratamiento con mayor aceptación en los atributos de color, sabor, aroma y apariencia, el producto terminado fue sometido a un panel de 40 personas para lo cual, se hizo uso de un Diseño Estadístico Completamente al Azar factorial en bloques y el programa SPSS versión 2018 para el análisis de resultados. Los resultados fisicoquímicos y microbiológicos realizados al mejor tratamiento (T5) fueron los siguientes: °Brix 8.7; acidez titulable 6.9 %; pH 7.8; humedad 7.02 % y cenizas totales 6.2 %; Coliformes totales < 6 x 10 UFC/g y recuento de mohos < 8 x 10 UFC/g. Por último, de los 6 tratamientos planteados, el T5 (45 % culén, 45 % menta y 10 % stevia a 40 °C) fue el más aceptado por el consumidor con tiempo de infusión de 1 minuto.
Efecto del fotoperiodo en las truchas (Oncorhynchus mykiss) sobre la maduración gonadal para inducir al desove fuera de estación reproductiva
Authors: Roca Dilmer , Manrique Lisbeth N. , Boza Washinton H.
Published: February 2023

El objetivo de esta investigación fue evaluar el fotoperiodo con luz artificial en las truchas (Oncorhynchus mykiss) para la maduración sexual de las gónadas. Se trabajó con 240 reproductoras de 3 años, de segundo desove, que fueron sometidas al fotoperiodo con luz artificial. Los tratamientos fueron T0 con luz natural, T1 con 18HL:6H0 (fotoperiodo largo) y el T2 con 18HO:6HL (fotoperiodo corto), durante 6 meses.  Se utilizó la energía fotovoltaica para cada cámara oscura, adaptada previamente. A los 3 meses, se realizó el cambio de fotoperiodo para el T1, fotoperiodo horas luz corto y T2 fotoperiodo de horas luz largo. La evaluación del desarrollo gonadal se realizó de manera manual mediante masajes ventrales en dirección opérculo-caudal. Cuando se obtuvieron las ovas maduras, se procedió a realizar el proceso de fertilización. Para ello, se utilizó semen de neomachos que fueron madurados con diferentes medios maduración, por 2 horas a 4 °C. Posteriormente, se realizó la fertilización a partir de ciertos parámetros. Los resultados no evidencian diferencias significativas (p<0.05) entre los tratamientos. Sin embargo, si la época de desove fue en diferentes meses para los tratamientos, para ambos tratamientos y en el testigo no se encontró óvulos maduros. Con respecto los siguientes parámetros número de ovas, volumen de ovas, total de ovas y el diámetro de ovas no fueron influenciados significativamente por los tratamientos (p-valor>0.05). Sin embargo, encontró una diferencia significativa que utilizaron diferentes medios maduración (p-valor<0.05).
Ganancia de peso vivo de terneros lactantes criados bajo dos sistemas de crianza y alimentación, Molinopampa, Perú
Authors: Rojas Diorman
Published: February 2023

El objetivo del presente estudio, consistió en evaluar la ganancia de peso vivo de terneros lactantes de la raza Brown Swiss, criados bajo dos sistemas: crianza y alimentación. La investigación se desarrolló en el distrito de Molinopampa, Amazonas, Perú, desde el 11 de noviembre del 2017 al tres de marzo del 2018, usando 12 terneros en la etapa de lactación, quienes presentaron similares características fenotípicas y genotípicas. Los terneros permitieron evaluar el efecto de las variables: sistema de crianza y sistema de alimentación, sobre los índices productivos, para lo cual se trabajó con un diseño Completamente al azar (DCA), con estructura factorial de tratamientos (2A x 2B). El factor A, estuvo representado por el sistema de crianza y el factor B por el sistema de alimentación. Como resultado se ha determinado que existen diferencias significativas entre las medias de los tratamientos para las variables: ganancia de peso vivo P 0.041 < α 0.05 y conversión alimenticia P 0.030 < α 0.05, obteniendo diferencias altamente significativas para la variable costo de producción P 0.000 < α 0.01. En cambio, para la variable mérito económico, se determinó que no existe diferencias significativas entre tratamientos P 0.097 > α 0.05.
Systemic mastocytosis with an associated hematological neoplasm (acute myeloid leukaemia with RUNX1::RUNX1T1 fusion) – A case study
Authors: Mehta Arpan , Dixit Hemangi , Mistry Krishna , Jinwala Prutha , Shah Parth
Published: February 2023

Systemic mastocytosis (SM) is a rare blood disorder that can affect multiple body organs. There are some patients of SM with coexpression of hematological neoplasm designated in the World Health Organization classification as SM with an associated hematological neoplasm (SM-AHN). A 13-year-old female was referred for immunophenotyping since blasts were reported in the bone marrow aspirate. On performing flow cytometry, abnormal myeloid blasts (>20%) were obtained on flow cytometry suggestive of acute myeloid leukemia with aberrant expression of CD19. Furthermore, there were increased mast cells abnormally expressing CD25. The aspiration slides reviewed showed atypical mast cells Type I and Type II. Molecular analysis revealed RUNX1::RUNX1T1 fusion as well as KIT D816V mutation. Karyotyping revealed a three-way translocation involving chromosomes 8, 12, and 21 consistent with RUNX1::RUNX1T1 fusion. Fluorescence in situ hybridization (FISH) performed using a dual color dual fusion probe for RUNX1::RUNX1T1 showed atypical abnormal pattern consistent with RUNX1::RUNX1T1 fusion. This rare diagnosis could be reached as a result of a strong correlation between morphology, immunophenotyping, cytogenetics, and molecular analysis, leading to a better treatment plan for the patient.
HER2 ‘neu’ promise for mCRC
Authors: Gohel Shruti , Lavingia Viraj
Published: February 2023

Following the staggering impact of anti-HER2 treatment in improving the outcomes for breast and gastric cancers, human epidermal growth factor receptor 2 (HER2 neu) has emerged as a promising new oncogenic target for metastatic colorectal carcinoma (mCRC) also. Through this article, we review the role of HER2 in mCRC as a prognostic biormarker as well as a poor predictive factor and mechanism of resistance against anti-EGFR therapy. We discuss the emergence of dual anti-HER2 blockade as effective therapeutic intervention for HER2 amplified mCRC and the advantageous role of ct-DNA in appropriate clinical setting. Furthermore, we explore the encouraging future paradigms for effectively targeting HER2 in mCRC.
Artificial intelligence in radiation oncology: How far have we reached?
Authors: Chufal Kundan Singh , Ahmad Irfan , Chowdhary Rahul Lal
Published: February 2023

Technological advances have revolutionized the field of radiation oncology (RO) as more and more departments are now equipped with modern linear accelerators and planning systems, resulting in the generation of a considerable amount of clinical, imaging, and dosimetric data. Artificial intelligence (AI) can utilize all these data points to create models which can expedite decision-making, treatment planning, and response assessment. However, various roadblocks impede the speed of development in this field. While data quality and security are the top priorities, legal and ethical issues are equally important. This scoping review provides an overview of the emerging possibilities resulting from an integration of modern RO workflow and AI-based technologies.
Hot Cross Bun Sign in Multisystematized Atrophy: The Cerebellar form HCB in MSA-c
Authors:   Department of Neuroradiology, Hospital of Specialties, ONO, Mohamed V University, Rabat, Morocco, A Waïs , B Wilson ,   Department of Neuroradiology, Hospital of Specialties, CHU Ibn SINA, Mohamed V University, Rabat, Morocco, K Raïssa ,   Department of Neuroradiology, Hospital of Specialties, ONO, Mohamed V University, Rabat, Morocco, F Meryem ,   Professor, Department of Neuroradiology, Hospital of Specialties, ONO, Mohamed V University, Rabat, Morocco, EK Najwa ,   Professor, Department of Neuroradiology, Hospital of Specialties, ONO, Mohamed V University, Rabat, Morocco, J Mohamed ,   Professor, Chef of Service, Department of Neuroradiology, Hospital of Specialties, ONO, Mohamed V University, Rabat, Morocco, T Firdaous ,   Professor, Department of Neuroradiology, Hospital of Specialties, ONO, Mohamed V University, Rabat, Morocco
Published: February 2023

Multisystematized Atrophy (MSA) is one of the Neurodegenerative causes generating Parkinson’s “plus” syndrome having three clinical forms a cerebellar form (MSA-c) characterized by cerebellar ataxia, a predominantly Parkinson form (MSA-p) and MSA with predominant autonomic signs and symptoms [1].
Late-Onset Pituitary Stalk Interruption Syndrome
Authors:   Department of Central Radiology, University Hospital Center Ibn Sina, Rabat, Morocco, D Ali Mohamed , A Ahmed ,   Department of Endocrinology and Metabolic Diseases, University Hospital Center Ibn Sina, Rabat, Morocco, I Fatima Zahra ,   Department of Central Radiology, University Hospital Center Ibn Sina, Rabat, Morocco, N Motassim Billah ,   Department of Central Radiology, University Hospital Center Ibn Sina, Rabat, Morocco, I Nassar ,   Department of Central Radiology, University Hospital Center Ibn Sina, Rabat, Morocco
Published: February 2023

A 21-year-old woman of low socio-economic status and no schooling consults for delayed puberty and primary amenorrhea. Her history includes a home delivery with no reported neonatal suffering. Examination revealed good general condition, normo-colored conjunctiva, statural delay at -3DS, absence of secondary sexual characteristics S1P1 of Tanner staging. Assessment of pituitary hormones showed collapsed GH and gonadotropin (LH and FSH) levels. Other hormones, including TSH/FT4 and ACTH, were normal. In view of the low FSH and LH levels, pituitary MRI was performed and showed an interruption of the pituitary stem with hypoplastic antehypophysis was about 2mm and pituitary stalk was interrupted (Figure 1 and 2). The patient received hormone replacement therapy.
Radiological Manifestations of Progressive Supranuclear Palsy
Authors:   Department of Radiology, The Specialty Hospital, Rabat, Morocco, ID Diallo , S EZ-Zaky ,   Department of Radiology, The Specialty Hospital, Rabat, Morocco, WM Traore ,   Department of Radiology, The Specialty Hospital, Rabat, Morocco, NE El Kettani ,   Department of Radiology, The Specialty Hospital, Rabat, Morocco, M Fikri ,   Department of Radiology, The Specialty Hospital, Rabat, Morocco, M Jiddane ,   Department of Radiology, The Specialty Hospital, Rabat, Morocco, F Touarsa ,   Department of Radiology, The Specialty Hospital, Rabat, Morocco
Published: February 2023

Progressive supranuclear palsy is one of the causes of atypical parkinsonian syndrome. We present the case of an 83-year-old patient with typical symptomatology suggesting progressive supranuclear palsy with characteristic imaging.
Decompensated Neuro-Behçet’s Disease Following Covid-19 Infection
Authors:   Department of Neurology, Military Hospital of Tunis, Tunisia, M Akkari , B Douma ,   Department of Neurology, Military Hospital of Tunis, Tunisia, M Mansour ,   Department of Neurology, Military Hospital of Tunis, Tunisia, H Derbali ,   Department of Neurology, Military Hospital of Tunis, Tunisia, M Messelmani ,   Department of Neurology, Military Hospital of Tunis, Tunisia, J Zaouali ,   Department of Neurology, Military Hospital of Tunis, Tunisia, R Mrissa ,   Department of Neurology, Military Hospital of Tunis, Tunisia
Published: February 2023

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) emerged in December 2019. Beside respiratory insufficiency, neurological complications have been observed with COVID-19. Here, we report a case of meningo-encephalitis following Covid-19 infection who decompensated a Neuro-Behçet’s disease. Case Presentation: A 45-year-old-man which is followed for Neuro-Behçet disease, hospitalized in the intensive care unit for altered state of consciousness. Brain magnetic resonance imaging (MRI) revealed a hyperintense area adjacent to right occipital horn. Cerebrospinal fluid (CSF) analysis revealed a meningitis with polymorphonuclear (PMN) cell predominance. The nasopharyngeal RTPCR was positive for SARS-CoV-2. The patient was treated with therapeutic anticoagulation, aciclovir and methylprednisolone sodium succinate and made a complete recovery. Conclusion: Our study identified a considerable burden of COVID-19 in patients with chronic neurological disorders.
Clinico-Radiological Correlation in COVID-19 Disease: Experience of the Hassan II University Hospital of Fez
Authors:   Department of Radiology, Hassan II University Hospital, Fez, Morocco, ID Diallo , A Sekkat ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, WM Traore ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, N Bouardi ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, M Haloua ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, MY Lamrani ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, M Boubou ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, M Maaroufi ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco, B Alami ,   Department of Radiology, Hassan II University Hospital, Fez, Morocco
Published: February 2023

Covid-19 disease has a great clinico-radiological polymorphism. Through this study, we illustrate the correlation between these lesions and the clinical presentation of patients infected by SARS-CoV-2 at the Hassan II University Hospital of Fez during the second wave.
Bifocal Squamous Cell Carcinoma (Bladder and Renal Pelvis): A Case Report
Authors:   Departement of Urology, Hospital Mongi Slim La Marsa, Tunisia, R Mejri , K Mrad Dali ,   Departement of Urology, La Rabta Hospital, Tunisia, K Chaker ,   Departement of Urology, La Rabta Hospital, Tunisia, S Ben Rhouma ,   Departement of Urology, La Rabta Hospital, Tunisia, Y Ouanes ,   Departement of Urology, La Rabta Hospital, Tunisia, Y Nouira ,   Departement of Urology, La Rabta Hospital, Tunisia
Published: February 2023

Urinary squamous cell carcinoma is a rare variety of urothelial tumors. We report a case of squamous cell carcinoma with dual location in the bladder and renal pelvis resulting in a fatal outcome in a patient suffering from a history of tobacco intoxication and recurrent upper urinary tract infections due to kidney stones. The CT scan showed a bladder tumor mass and a small left kidney destroyed by lithiasis. The study of the kidney surgical specimen confirmed a second location of squamous cell carcinoma. After a review of the literature, this is the first case of a bifocal squamous cell carcinoma.
Pulmonary Interstitial Emphysema in 20-Year-Old Male
Authors:   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, A Chaimae , M Oumaima ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, B Wilson ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, O Mustapha ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, F Meriem ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, EKN Ech-Cherif ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, J Mohamed ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco, T Firdaous ,   Department of Radiology, Hospital of Specialities, CHU Ibn Sina, Mohamed V University, Rabat, Morocco
Published: February 2023

A young man of 20 years, diagnosed and operated in 2010 for a tumor of the Posterior cerebral Fossa (pilocytic astrocytoma), presented intracranial hypertension syndrome in which a Cerebral MRI found a cystic tumor process with hemorrhage, situated in the right hemisphere and vermis, complicated with an active triventricular hydrocephaly, which he got operated for. During his post-operatory stay in reanimation, he presented acute dyspnea for which a chest CT was performed.
A Proposal of a Head Holder for CT Scan Tables: A New Fixation Design
Authors:   Radiology Specialist, Department of Radiology, Al-Namas General Hospital, Ministry of Health, Al-Namas City, Saudi Arabia, A Alahmari
Published: February 2023

All the current headsets for CT scanners tables use very weak immobilizations techniques which can’t work with Parkinson’s or Huntington’s patients. Some head holders use expanding balloons to hold the patients head, but it can’t stop involuntary movement. Therefore, this paper proposes more radical design that can be used especially with such conditions but with an intact skull.
Renal Segmental Artery Resistive Index as a Non-Invasive Indicator of Functional Deterioration in Patients with Chronic Kidney Disease
Authors:   Department of Radiodiagnosis and Imaging, Shahid Gangalal National Heart Centre, Bansbari, Kathmandu, Nepal, NP Neupane , K Koirala ,   Department of Radiodiagnosis and Imaging, Nepal Medical College Teaching Hospital, Jorpati, Kathmandu, S Koirala ,   Nepalese Army Institute of Health Sciences, Syanobharyang, Kathmandu, B Lohani ,   Department of Radiodiagnosis and Imaging, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu
Published: February 2023

Background: Chronic kidney disease refers to the gradual loss of renal function over time and is a significant public health problem worldwide. Doppler ultrasonography can be used as a non-invasive modality to detect renal macroabnormalities and renal vascular status in these patients. The objective of our study was to assess the role of renal segmental artery resistive index in the evaluation of the renal functional status in patients with different grades of chronic kidney disease. Methods: A hospital-based study using a non-interventional study design was employed in the study. The inclusion criteria were adult patients between 20 to 60 years of age with chronic renal disease but not undergoing renal replacement therapy. Renal Doppler was performed by a single operator on these patients with a curvilinear probe of 3.2 megahertz. Data were entered in a predesigned proforma, and analysis was done using IBM SPSS version 20. Results: The mean renal segmental artery resistive index in our study was 0.74 (SD=0.08) for the right kidney and 0.75 (SD=0.07) for the left kidney. A positive correlation was observed between the grade of chronic kidney disease and segmental artery resistive index with an r-value of 0.76 and 0.72 for the right kidney and left kidney, respectively. Conclusion: The renal segmental artery resistive index can be used as a non-invasive indicator for evaluating patients with chronic kidney disease. It correlates with the renal functional status as estimated by the glomerular filtration rate. It can be used as a marker for deterioration of renal function and can also prognosticate the outcome in patients with chronic kidney diseases.
Stenosis of the trunk of the left coronary artery in idiopathic pulmonary hypertension. Case report
Authors: Ivanov Sergei N. , Edemskiy Alexander G. , Vasiltseva Oksana Ya. , Chernyavskiy Aleksandr M. , Kalashnikova Maria V. , Seletskaya Svetlana V.
Published: February 2023

The manuscript presents a clinical case of treatment of a patient with idiopathic pulmonary hypertension and a rare complication left main coronary artery stenosis caused due to compression by the dilated pulmonary artery. This complication was clinically manifested by chest pain. The patient underwent percutaneous coronary angioplasty with stenting of the left main coronary artery and subsequent prescription of combined PAH-specific therapy. During the late follow-up examination in addition to clinical improvement and the absence of pain, 6-minute walking test distance increase, positive dynamics of echocardiography, right heart catheterization, as well as the laboratory marker of heart failure NT-proBNP were noted.
The role of interleukin-6 in the development of cardiovascular diseases: A review
Authors: Alieva Amina M. , Butenko Aleksei V. , Teplova Natalia V. , Reznik Elena V. , Valiev Ramiz K. , Skripnichenko Elina А. , Sozykin Aleksei V. , Nikitin Igor G.
Published: February 2023

Currently, the search and study of new biological markers that can provide early diagnosis of cardiovascular diseases, serve as a laboratory tool for assessing the effectiveness of treatment, or be used as prognostic markers and risk stratification criteria is ongoing. Our literature review indicates the potentially important diagnostic and prognostic value of assessing members of the interleukin-6 family. It is expected that further scientific and clinical studies will demonstrate the possibility of using members of the interleukin-6 family as an additional laboratory tool for the diagnosis, risk stratification and prediction of cardiovascular events in cardiac patients. It is necessary to evaluate in detail the possibilities of blockade of these interleukin-6 molecules in patients with cardiovascular diseases in vitro and in vivo.
Atopic diseases and oncopathology. What do they have in common? A review
Authors: Ustimenko Valeriya I. , Logvinenko Nadezhda  I.
Published: February 2023

The increasing prevalence of cancer worldwide has influenced the interest of researchers to search for factors that may trigger oncogenesis in order to prevent and treat cancer. There is a burning question, can allergic diseases cause or prevent cancer? Numerous epidemiological studies have been conducted that have evaluated aspects of the relationship between allergic diseases and the occurrence of cancers of various localizations. The results of most of these studies are inconsistent, both in the nature of the course of the disease and in the variety of localizations of the occurrence of cancer. In this connection, two basic theories were suggested: the theory of immune surveillance and the theory of inflammation. This review analyzed current scientific work to estimate the incidence of neoplasms against the background of atopic diseases. The analysis of clinical studies shows inconsistent results of the association between allergic diseases and cancer. Several studies an inverse relationship between atopic diseases and cancer risk, which supports the theory of immune surveillance [brain tumor (glioma), pancreatic cancer, colorectal cancer, non-Hodgkin's lymphoma, and breast cancer, cancer of the mouth and throat, larynx]. At the same time, a number of studies note a positive association between atopic diseases and cancer, which confirms the theory of chronic inflammation (lung cancer and colorectal cancer combined with bronchial asthma). The lack of an unequivocal explanation testifies to the urgency of long-term prospective studies aimed at studying the risk factors of cancer in combination with atopic diseases with the subsequent development of risk scale for the purpose of patient stratification, screening, development of early detection programs and new approaches to the treatment of malignant neoplasms.
Differential clinical signs of aphasia syndrome in acute and residual recovery periods. Directions of neurorehabilitation of patients with aphasia syndrome depending on the recovery period
Authors: Shcherbakova Maria M.
Published: February 2023

Background. Speech and cognitive disorders of vascular genesis account for a significant percentage of the existing consequences of local disorders of cerebral circulation. Approximately 2140% of stroke patients suffer from persistent aphasia, which gradually worsens the quality of life and rehabilitation results.
Aim. Improving the quality of neurorehabilitation of patients who have suffered a brain stroke.
Materials and methods. The analysis of differential clinical signs of aphasia syndrome in patients of neuro-intensive care and vascular neurological departments was carried out. The typical clinical symptoms of aphasia syndrome characteristic of ICU patients were identified, a rehabilitation direction was proposed that promotes rapid compensation of syndromes in the acute recovery period (up to 88% of cases). The clinical signs of aphasia syndrome at the late, residual recovery stage have been clarified. An effective method of neurorehabilitation of patients with aphasia syndrome in the late recovery period (significant positive dynamics up to 85% of cases) is proposed.
Results. Achieved high results in the reversibility of the aphasia syndrome, both at an early and late, residual, recovery stage.
Conslusion. Aphasia syndrome in acute and residual recovery periods has a certain specificity of its clinical manifestation. This factor must be taken into account: 1) when making speech diagnoses; 2) when planning rehabilitation programs. An effective rehabilitation technique for the aphasia syndrome involves a functional reorganization of mental processes, which allows speech thinking to either completely return or get as close as possible to its original state, regardless of the stage of recovery work.
Algorithms for management of patients with severe A/H1N1 influenza: from diagnosis to respiratory support techniques. Guidelines
Authors: Avdeev Sergey N. , Zaytsev Andrey A. , Zhdanov Konstantin V. , Patsenko Mikhail B. , Chernov Sergei A. , Stets Valerii V. , Potekhin Nikolai P. , Sergoventsev Aleksander A. , Davydov Denis V. , Kryukov Evgeniy V. , Chernetsov Vladimir A.
Published: February 2023

In 2022, the incidence of swine (A/H1N1) influenza markedly increased. It causes acute lung injury similar to that caused by SARS-CoV-2. These practice guidelines focus on the management of patients with severe influenza: from the diagnostic algorithm to the specifics of therapy and the use of respiratory support techniques. The guidelines provide recommendations on the rational pharmacotherapy principles: antiviral, antibacterial, mucoactive, anticoagulant, and symptomatic. The need to avoid prescribing drugs that may worsen the condition of patients with A/H1N1 influenza that are effective in other viral lung diseases, including SARS-CoV-2, has been pointed out. A detailed review of the criteria for initiation and principles of respiratory support is given.
The impact of sports on the normal functioning of the prostate gland: A review
Authors: Ershov Anton V.
Published: February 2023

This article explores the relationship of physical activity to the normal functioning of the prostate gland. The biomechanism of hormonal activity during exercise was studied, and special attention was paid to the biomechanism of an actively working muscle and the release of myokines. The analysis of the relationship between myokines and the functioning of the prostate gland was carried out. It has been established that physical activity reduces the risk of developing prostate diseases and is an important method of prevention.
Updated the Maastricht VI/Florence Consensus recommendations for the treatment of Helicobacter pylori infection: A review
Authors: Pimanov Sergei I. , Makarenko Elena V.
Published: February 2023

The new Maastricht VI/Florence Consensus clarifies a number of provisions that were previously under discussion. It has been postulated that Helicobacter pylori infection always causes gastritis, regardless of symptoms or complications. Before making a convincing diagnosis of functional dyspepsia, it is necessary to exclude Helicobacters gastritis. Some provisions of the consensus, such as the test and treat tactic, require elements of a critical attitude, taking into account Russian regional conditions. About 90% of stomach cancers are due to H. pylori. Eradication of H. pylori makes it possible to prevent gastric cancer at any age in adulthood, but the effectiveness of such cancer prevention decreases with age. Bismuth quadruple therapy is preferred in the eradication therapy algorithm. Decreased value of triple treatment with clarithromycin. There is a rapid increase in H. pylori resistance to fluoroquinolones. Triple therapy with rifabutin is called the final eradication protocol.
Building a virus propagation modelin a computer network based on a comparison of results simulations with empirical data
Authors: Еремеева Нина Игоревна
Published: February 2023

В статье на основе SI-модели построена иерархия четырех математических моделей, описывающих распространение компьютерного вируса в сети при отсутствии возможности лечения зараженных хостов. Каждая следующая модель отличается от предыдущей введением в рассмотрение нового фактора. Для построенных моделей проведено сравнение результатов численного моделирования с экспериментальными данными (статистическими данными, опубликованными в 2002 году Д. Муром, К. Шенноном и Д. Брауном). На основе построенных моделей с использованием некоторых элементов PSIDR-модели, создана модель, описывающая распространение компьютерного вируса в сети при наличии возможности лечения зараженных хостов, а также проведен численный эксперимент, позволяющий проследить динамику численности всех групп, участвующих в эпидемиологическом процессе.

The article uses the SI model to construct a hierarchy of four mathematical models describing the spread of a computer virus on the network in the absence of the possibility of treating infected hosts. Each subsequent model differs from the previous one by introducing a new factor into consideration. For the constructed models, numerical simulation results were compared with experimental data (statistical data published in 2002 by D. Moore, K. Shannon and D. Brown). Based on the constructed models using some elements of the PSIDR model, a model was created describing the spread of a computer virus in the network if there is a possibility of treating infected hosts, and a numerical experiment was carried out to trace the dynamics of all groups involved in the epidemiological process.
Negative $\lambda$-binomial regression in dose-effect relationship
Authors: Тихов Михаил Семенович
Published: February 2023

Эта статья посвящена проблеме оценки функции распределения и ее квантилей в зависимости доза-эффект с непараметрической отрицательной $\lambda$-биномиальной регрессией. Здесь предложены ядерные оценки функции распределения, ядро которых взвешивается отрицательной $\lambda$-биномиальной случайной величиной при каждой ковариате. Наши оценки состоятельны, т.е. сходятся к своим оптимальным значениям когда число наблюдений $n$ возрастает до бесконечности. Показано, что эти оценки имеют меньшую асимптотическую дисперсию по сравнению, в частности, с оценками типа Надарая-Ватсона и других оценок. Представлены непараметрические оценки квантилей, полученные путем инвертирования ядерной оценки функции распределения. Асимптотическая нормальность этих оценок с поправкой на смещение сохраняется при некоторых условиях регулярности. В первой части анализируются соотношения между моментами отрицательного $\lambda$-биномиального распределения. Получена новая характеризация распределения Пуассона.

This paper is concern to the problem of estimating the distribution function and its quantiles in the dose-effect relationships with nonparametric negative $\lambda$-binomial regression. Here, a kernel-based estimators of the distribution function are proposed, of which kernel is weighted by the negative $\lambda$-binomial random variable at each covariate. Our estimates are consistent, that is, they converge to their optimal values in probability as $n$, the number of observations, grow to infinity. It is shown that these estimates have a smaller asymptotic variance in comparison, in particular, with estimates of the Nadaray-Watson type and other estimates. Nonparametric quantiles estimators obtained by inverting a kernel estimator of the distribution function are offered. It is shown that the asymptotic normality of this bias-adjusted estimator holds under some regularity conditions. In the first part, the relations between the moments of the negative $\lambda$-binomial distribution are analyzed. A new characterization of the Poisson distribution is obtened.
On Jonsson varieties and quasivarieties
Authors: Дудаков Сергей Михайлович
Published: February 2023

В работах некоторых авторов было введено понятие йонсоновского многообразия и квазимногообразия и для таких классов алгебраических систем доказаны разного рода утверждения. Мы показываем, что на самом деле йонсоновские многообразия и квазимногообразия ограничиваются всего лишь классами множеств и либо пунктированных множеств в зависимости от сигнатуры. Таким образом, результаты, полученные в упомянутых выше работах другими исследователями, является тривиальными.

Earlier the notion of a Jonsson varieties and quasivarieties was introduced. For these classes of algebraic structures various assertions were proven by some researchers. We show that Jonsson varieties and quasivarieties are exactly classes of sets or pointed sets, it depends on signature. Thus, the results from the works mentioned above are trivial.
Calculation of temperature field generated by a system of turbular electric heating elements inside a metal press
Authors: Сыромясов Алексей Олегович
Published: February 2023

Работа посвящена численному моделированию системы трубчатых электронагревателей (ТЭНов), внедренных в стальную плиту (пресс), которая покоится на слое инородного материала - дерева или древесноволокнистой плиты МДФ. Целью расчетов является определение количества и мощности ТЭНов, обеспечивающих заданный прогрев пресса. Средняя температура на поверхности соприкосновения стали с МДФ задана, а перепад температур в различных точках этой поверхности не превышает определенного значения, диктуемого особенностями обрабатываемого материала. Результаты расчета внедрены на производстве.

The paper is devoted to numerical simulation of a system of turbular electric heating elements that are embedded in a steel plate (a press) basing on a slice of some other material, i.e. wood or MDF. Calculation purpose is to find the number and the power of heating elements that guarantee preselected heating regime of the press. In more detail, average temperature on the contact surface of the press and MDF is given, and temperature drop on this surface must not exceed some value determined by the properties of material under treatment. The simulation results are adopted by a certain company producing wood-fibre boards.
Experiencias de participación en salud de adolescentes y jóvenes en tiempos de la pandemia de COVID-19 en Chile
Authors: Brito-Placencia Dennisse , Burattini-Fredes Natalia , Martínez-Santana Dayann , Sánchez-Montecinos Solangela , Farías-Cancino Angélica , Contreras-Galvez Alejandra , Sandoval-Zavala Magaly , Caffe Sonja , Abaakouk Zohra
Published: February 2023

Objetivo.

Develar las experiencias y determinantes de la participación de adolescentes y jóvenes en mecanismos formales de participación durante la pandemia por SARS-CoV-2 en Chile.

Métodos.

Estudio transversal, descriptivo de enfoque cualitativo, adscrito al paradigma constructivista de investigación. Se realizaron 3 grupos focales con informantes claves, adolescentes y jóvenes, quienes participan regularmente en consejos consultivos del Ministerio de Salud (MINSAL) en Chile. Se aplicó la técnica de análisis de contenido para categorías teóricas y emergentes del estudio. Los relatos fueron transcritos y estudiados con técnica de análisis de datos y hermenéutica. Este estudio fue realizado durante la pandemia de COVID-19, entre los meses de marzo y noviembre del 2021.

Resultados.

Durante la pandemia, las experiencias de participación en salud de adolescentes y jóvenes se vieron afectadas; no obstante, los mecanismos de participación formales, como los consejos consultivos, permitieron dar continuidad. En este contexto, adolescentes y jóvenes dentro de sus experiencias destacaron algunos factores que facilitaron o limitaron la participación, de acuerdo con tres niveles de gestión: individual, relacional y estructural, destacándo la comunicación virtual, el uso de redes sociales y la salud digital como excelentes herramientas para la participación de jóvenes y adolescentes en tiempos de pandemia en Chile.

Conclusión.

La pandemia ha afectado a los mecanismos de participación de adolescentes y jóvenes en Chile. No obstante, dentro de las experiencias destacadas por los jóvenes han surgido aspectos como la comunicación virtual, la salud digital y otras estrategias que han facilitado la participación. Por otro lado, en esta crisis sanitaria mundial se han acrecentado algunas brechas en la participación en salud, como el acceso principalmente en poblaciones rurales.
Визначення чинників могутності Ірану з огляду основних концепцій регіонального лідерства
Authors: Zarytska Olena , Shynkaruk Nataliia
Published: February 2023

Однією з найголовніших особливостей регіональної геополітичної карти Близького Сходу початку XXI століття стало посилення впливу Ісламської Республіки Іран, який полишив принцип пасивного підходу до регіональних справ, яким він загалом слідував у часи холодної війни та перейшов до фази активного регіонального позиціонування. Упродовж останніх 20 років Іран активно домагається визнання себе як законної регіональної держави на Близькому Сході. Подібні намагання категорично не сприймаються всередині регіону та з обережністю і скептицизмом – за його межами. Зростаюча роль Ірану, без сумніву, визнається міжнародною спільнотою, але те, якими методами Тегеран реалізує свій вплив, викликає величезне занепокоєння. Захід закликає Тегеран вийти із регіональної боротьби, але режим не погоджується здавати регіональні позиції інакше як на гарантії власної національної безпеки. Цікавим в цьому аспекті постає питання – чи насправді Ісламська Республіка Іран представляє собою країну із статусом регіонального лідера, або, навпаки, керується лише захистом національних інтересів, а, отже, не може повною мірою називатися лідером на Близькому Сході. З метою з’ясування чи є сьогодні Іран регіональним лідером, авторами була застосована класифікації німецького дослідника Д. Нолте. У результаті, проведеного аналізу можна стверджувати, що Ісламська Республіка Іран відповідає багатьом вимогам регіональної держави, що зростає на рівні регіонального гравця середньої сили. Втім, фактори іранської міцності не є достатніми для здобуття Іраном регіонального лідерства. Першопричиною чого є ідеологічні розбіжності, недовіра, політичний шантаж та маніпуляції, підкріплені військовою підтримкою незаконних повстанських рухів та ін.