bluuebunny/crossref_metadata_2025 huggingface dataset:
Concept Mapping STI/HIV Prevention and Condom Use among Young African American Adults
Authors: Carmack Chakema , Nganga Sarah , Ahmed Eisha , Coleman Taylor
Published: June 2024

Theory-based HIV prevention programs have resulted in increased condom use, which remains the best method for the prevention of sexually transmitted infections (STIs) among sexually active heterosexual individuals. Particularly, the integrative model of behavior prediction theorizes that attitudes, norms, self-efficacy, and socioenvironmental factors influence intention and behavior and has been useful in understanding STI risk among adolescents. However, more research is needed regarding young African American adults. Given the increased freedom and decision-making independence afforded to young adults compared to adolescents, it is important to consider the STI/human immunodeficiency virus (HIV) prevention messages that would resonate with them, particularly regarding condom use. The present study sought to explore how attitudes, subjective norms, self-efficacies, and socioenvironmental factors may influence condom use and STI/HIV prevention, as conceptualized by the participants. We conducted a group-based concept map, a systems-thinking mixed methodology that resulted in a geospatial map reflecting the conceptualizations of the participants. Self-identified young heterosexual African American adults (N = 43) aged 20–26 engaged in an interactive concept mapping procedure in order to “map out” their overarching concepts about STI/HIV risk and condom use. Seven overall conceptual domains emerged: self-efficacy for partner communication, condom use self-efficacy, social media/sociocultural influences, condom use/STI knowledge, condom use cons, condom use pros, and subjective and social norms about condom use. We presented the concept map and discussed the conceptual interpretations and the relationships among the overarching concepts. We also discussed how the social environment, including the social media environment, was conceptualized regarding STI/HIV risk and prevention among young African American adults. Concept mapping can be viewed as a way to determine worthwhile messages for intervention development. The findings may provide information for prevention programs aimed at reducing the incidence of STIs among young adult heterosexual persons within African American communities.
Factors Influencing Users’ Perceptions of Digital Platform Indispensability: A Comparative Study of Korea and Finland
Authors: Jang Moonkyoung , Nikou Shahrokh , Kim Seongcheol
Published: June 2024

The pervasive integration of digital platforms into daily life has amplified their perceived indispensability. This study investigates the factors influencing this perception across countries with contrasting platform landscapes, focusing on platform quality and usage patterns. We conducted surveys in Finland and Korea, countries representing distinct platform ecosystems. The results revealed higher perceived indispensability in Korea than in Finland, with usefulness and habitual platform use emerging as significant predictors of indispensability in both countries. However, the specific aspects of platform quality influencing this perception diverged. In Finland, the platform’s comprehensiveness and security risk significantly impacted indispensability, while social interaction features played a negligible role. Conversely, in Korea, social interaction features significantly influenced indispensability, while platform comprehensiveness and security risk were non-significant. These findings underscore the multifaceted nature of digital platform indispensability, shaped by the interaction of platform quality and usage patterns. The contextual variations highlighted by our cross-country comparison suggest that a one-size-fits-all approach to platform regulation or user education may be ineffective. Future research should explore these cultural and platform-specific nuances to devise tailored policies.
Research on the Production Capacity Evaluation of Prefabricated Component Manufacturing Enterprises
Authors: Cao Lifei , Cong Weiyi , Su Yikun , Zheng Zhizhe
Published: June 2024

Due to the industrialization of the construction sector, enterprises that manufacture prefabricated components are developing rapidly. Because the production capacity of each enterprise varies immensely, the upstream enterprises are unable to match the component manufacturing enterprises that are suitable for the supply target. With respect to the product capacity, scientific and accurate evaluations are crucial. The authors preliminarily determined factors that impact the production capacity of components and considered a literature review and the inspection results of component manufacturing enterprises. By performing a thorough investigation and analysis, they constructed the index system for evaluating the production capacity of enterprises that manufacture prefabricated components, and each index was interpreted. To determine the weight of the evaluation index, an analytic hierarchy process was utilized; furthermore, the characteristics of each grade were described, and a fuzzy comprehensive evaluation model was built. Moreover, to empirically analyze the built model, the authors selected a construction company and analyzed 127 questionnaires filled in by employees at all the organizational levels related to PCT production and to 34 evaluation results of experts from standard quota research institutions in various provinces. The results of the two methods revealed the following: This enterprise level is the “Reinforcement level” (level 3). The evaluation results are consistent with the empirical results of the model established herein, which verifies its feasibility.
Enhancing BIM Integration: A Comparative Analysis of Novel Composite Structure Documentation Methods
Authors: Szalai Dóra , Ajtayné Károlyfi Kitti
Published: June 2024

The proper selection and planning of building materials are crucial tasks in architectural design, as they fundamentally impact the functioning of the structure. In traditional design processes, this information is recorded in text form, typically using word processing software. However, this approach hinders the integration with modern, data-driven design methods and is incompatible with the increasingly popular building information modeling (BIM) processes. To address this, two new methods have been developed: one database-like method in the form of an Excel spreadsheet and the other as a dedicated web application. This article introduces and compares these methods based on pilot projects conducted by university students and an expert. Based on the results of the study conducted among students and expert, the database-like method proves to be the fastest. For students, creating a composite structure took an average of 14–20 min, while for experts, it took an average of 1.2 min. According to the evaluation of participants, the traditional method does not facilitate automatic communication with BIM, while both the database and web solutions promote it. The web-based solution, with its dedicated layout and functionality, offers additional advantages in this regard. The research underscores the importance of structured data in BIM and proposes new methods to streamline composite documentation processes during the design phase.
Effect of Project Control Practices on the Performance of Building Construction Companies in Uganda: A Case Study of the City of Kampala
Authors: Tukundane Hillary , Yang Yu
Published: June 2024

This research paper analytically evaluates the project control practice levels used by the building construction companies within Kampala, Uganda. The research also assesses the impact of project control practices on the productivity of companies. The research was performed to ascertain the current control practices among 160 respondents from various construction companies registered with the Uganda Registration Services Bureau. This research used amalgamation from multiple studies in the literature to obtain the variables. This research adopts 34 standard control practices from 4 vital project control duties: planning, monitoring, analyzing, and reporting. These project control tasks were organized using mean response ratings grounded in their relevance to the construction companies. This process authorized researchers to prioritize tasks based on their perceived importance or relevance to the construction companies involved. Results showed that evaluating performance with the use of S-curves (4.32), timely access to information and encouragement (4.55), report representation using quantitative tools 4.75, and cost value comparison application during analysis (4.76) were rated least among the control practices. On the other hand, the top project control practices included formulation of the project schedule (8.88), project feasibility validation (8.86), budgeting for each activity (8.84), key project route definition (8.81), team awareness of the budget (8.77), setting realistic targets for projects (8.50), and consultation from subcontractors (8.74). From the results obtained by the sample respondents specified, it can be concluded that planning is the most vital project control task practiced in the building construction industry in Uganda. In addition, this research ascertained a substantial relationship between project control practices and the performance of building construction companies. Accordingly, this research recommends that project control practices be effectively observed by both contracting and consulting companies to enhance their overall performance and governance.
Experimental Investigation of the Bond Performance at the Interface between Engineered Geopolymer Composites and Existing Concrete
Authors: Li Zhibin , Tan Jiaqi , Ouyang Ji , Yu Yongxin , Li Shibin , Lin Taoxin , Liu Runan , Li Wen
Published: June 2024

Engineered geopolymer composite (EGC) exhibits ultra-high toughness, excellent crack control capability, and superior durability, making it highly promising for applications in bridge connecting slabs, wet joints of prefabricated components, and concrete structure reinforcement. However, the bond performance and failure mechanisms at the interface between EGC and existing concrete remain unclear. To elucidate the bond performance of EGC to existing concrete, direct shear tests were conducted on 15 sets of EGC–existing concrete bond specimens. This study explored the effects of existing concrete strength, interface roughness, and EGC strength on the bond performance and mechanisms. Additionally, a direct shear bond mechanical model was established to predict the interface bond strength. The results indicate that, with comparable compressive strength, the preparation of EGC can reduce the total carbon emissions by up to 127% compared to ECC. The failure mode of EGC-existing concrete bond specimens was mainly adhesive failure (except for specimen C30-III-G95), which can be categorized into serrated interfacial failure and alternating crack paths. The change in interface roughness was the primary factor leading to the transition between failure paths. The changes in interface roughness and EGC strength significantly influenced the bond performance. Under their combined effect, the interface bond strength of specimen C50-III-G95 increased by 345% compared to C50-I-G45. In contrast, the improvement in existing concrete strength had a relatively smaller effect on the increase in interface bond strength. Based on the experimental results and the bonding mechanism under direct shear stress, a direct shear bond mechanical model correlating existing concrete strength, interface roughness, and EGC strength was established. The model predictions showed good consistency with the experimental results. This study provides theoretical support and experimental data for the engineering application of EGC.
Evaluation of Synchronous Use of Portable Personal Comfort and Environment Conditioning Systems in Real Office Occupancy Conditions
Authors: Wegertseder-Martinez Paulina , Berges-Alvarez Ileana , Piderit-Moreno Beatriz
Published: June 2024

Personal Comfort Systems (PCSs) have emerged as an innovative solution to address variable individual conditions that traditional comfort models excluded. This study investigates the impact of the simultaneous application and use of three PCSs in real office environments on an occupant’s thermal, light, and air quality perception and seeks to understand different environmental stimuli behind personal actions and behaviors. It uses qualitative and quantitative monitoring of specific environmental conditions and individual actions of 72 participants in four office buildings in different climatic zones of Chile in summer and winter. The PCSs tested differ in their costs, technological level, usability, and portability. The results show that 85.5% improved their perceived comfort by using the PCSs, although not from simultaneous use, but rather from the use of one system over another. The desk fan stands out as having the highest acceptance and utilization rate. However, certain environmental conditions cause opposite actions: limited lighting control or little daylight causes the fan to be turned on. The present study’s data could contribute to a new environmental comfort model for shared office spaces, fostering significant improvements in occupant satisfaction and energy efficiency. This practical and scientific research is of interest to architects, designers, and stakeholders from the construction production field.
Public Perception of Accommodation Structures in the Cultural Landscape: An Exploration of Integration and Significance
Authors: Oltean Raul-Catalin , Arion Felix Horatiu
Published: June 2024

Since the end of the communist era in Romania (c. 1989) an economic shift has influenced new construction in the rural parts of the region. New construction faces challenges due to a potential clash between the historic architectural style of the region and the surrounding environment that has been highlighted by the architectural guidebooks from the Romanian Order of Architects. Research surrounding the preference of the region’s inhabitants is limited. A survey was conducted to analyze three main questions and their significance for individuals native to the region and for specialists. This survey addresses how the respondents (1) will define the blending (and the differences between blending and integration), (2) how respondents evaluate the blending of construction styles, and (3) if it is important to pay attention to the visual impact of new construction. These architectural considerations were identified after a literature review illuminated concerns regarding landscape blending disparities due to new construction and where the survey was conducted using a diverse sample population of individuals who were engaged in the study via social media. Respondents were shown images of buildings and asked to rate the blending of these structures with the cultural landscape using a scale from one to five. The survey data were collected and analyzed to determine preferences in each key area. The findings indicate that respondents perceive blending as a valuable tool, with a significant visual impact, favoring positive examples irrespective of their professional background. Notably, there is a substantial preference for positive examples over negative ones regarding color. However, respondents without experience in the field tend to choose negative options more often. Researchers anticipate that these findings could inform the planning process and aid in seamlessly integrating new construction with the traditional and natural elements of the region.
Decarbonization Potential of Energy Used in Detached Houses—Case Study
Authors: Kalmár Ferenc , Bodó Béla , Li Baizhan , Kalmár Tünde
Published: June 2024

The main objectives of this study were the energy assessment of detached houses built in different periods in a central European city. A total of 236 detached houses built between 1930 and 2023 in Debrecen (Hungary) were analyzed from an energy perspective, and their CO2 emissions were measured. It was found that the net floor area of family houses built in recent years has increased but that the compactness of buildings has increased as well. The specific heat loss coefficient and the specific energy demand for heating in new buildings have decreased to 15.2% and 18.5%, respectively, over the last 90 years. Furthermore, around one third of the analyzed buildings built several decades ago must have already been renovated at least once for energy efficiency, as their heat demands are 27.6–41.4% lower than estimated. Energy consumption in six houses built in recent years was measured and studied. It was found that the occupants’ behavior may increase CO2 emissions from heating by 26%, while CO2 emissions from hot-water preparation may decrease by 38.2%. The potential of the locally available sources of renewable energy was calculated, and the costs of decarbonization packages for eight building groups were evaluated.
Experimental Study on Small-Scale Shake Table Testing of Cable-Stiffened Single-Layer Spherical Latticed Shell
Authors: Zhao Ying , Zhang Zhiyu , Chen Yuzhen , Lu Cheng , Zhou Yu , Zhang Tianhao , Li Pengcheng , Xiong Gang
Published: June 2024

The cable-stiffened single-layer latticed shell is an innovative structural design that achieves a perfect balance between lightweight and stability by combining cables and a latticed shell. However, the study on dynamic response and failure mechanism of cable-stiffened single-layer latticed shell under seismic action is still lacking. Therefore, small-scale shaking table tests of two kinds of single-layer spherical latticed shells are carried out; the dynamic response and failure mode of the two shells under sine wave earthquake are investigated by using time history analysis. The conclusions show that the introduction of the prestressed cable plays an important role in improving the seismic performance of the single-layer latticed shell, and the cable-stiffened single-layer latticed shell has better load capacity and seismic performance under earthquake action than the ordinary single-layer latticed shell structure.
Performance Evaluation and Degradation Analysis of Suspended Dense Broken Stone Road Foundation Stabilized by Cement under Conditions of Freezing and Thawing
Authors: Deng Haihong , Huang Kainan , Wu Fei , Wang Yinghan
Published: June 2024

A suspended dense graded broken stone road foundation stabilized by cement is a commonly employed material in roadworks, which is vulnerable to harm caused by freezing and thawing processes. This investigation intends to evaluate the laboratory behavior and the characteristics of freezing and thawing process-induced deterioration in a broken stone road foundation stabilized by cement with suspended dense grading, employing mechanical examinations and acoustical methods. The rate of mass loss in the broken stone road foundation stabilized by cement progressively rises, and the rate of decline in the compressive strength could potentially intensify as freezing and thawing processes augment. The modulus of resilience diminishes as freezing and thawing processes progress, and ultrasonic wave velocity also decreases. The patterns of mass loss, compressive strength decline, resilience modulus reduction, and ultrasonic wave velocity alteration adhere to a parabolic fitting relationship with freeze–thaw cycles, with an R2 above 0.95. The curves depicting the relationship of mass, compressive strength, resilience modulus, and ultrasonic wave velocity exhibit a steeper trend significantly after 10–15 cycles, which can be ascribed to the emergence of microcracks and the progression of flaws within the material. The evolution of damage in the broken stone road foundation stabilized by cement is monitored to progress through three distinct stages based on acoustic emission: initial, stationary, and failure. As freezing and thawing processes accumulate to 20 cycles, the length of initial phase correspondingly rises to three times, the length of failure stage diminishes to about one fifth.
Systematic Review on the Barriers and Challenges of Organisations in Delivering New Net Zero Emissions Buildings
Authors: Mahmoodi Masoud , Rasheed Eziaku , Le An
Published: June 2024

Achieving the net zero emissions target that was set in the Paris Agreement to mitigate the risks of climate change seems increasingly difficult as countries and sectors of the economy are falling behind the expected trajectory. The building and construction industry, as one of the main contributors to global emissions, has an essential role to play toward this aim. Net zero emissions target has been introduced to this sector as well; however, achieving it is a very challenging and complex task. Many studies have been undertaken on implementing different measures and strategies to reduce the industry’s carbon footprint. These studies identified many challenges and barriers in transforming the industry. This paper aims to provide a systematic review of challenges that organisations face in delivering new net zero emissions buildings. The relevant journal articles published since the Paris Agreement were identified and analysed using mixed-method data analysis, including quantitative (science mapping) and qualitative (thematic) analysis. The result showed increased attention to the subject over this period, with China, the UK, and Australia being the top contexts for research. The most discussed groups of barriers were “economic”, “knowledge”, and “technical”, respectively, followed by “organisational”, “market”, “technological”, and “legal” barriers.
A Review of Factors Affecting the Lighting Performance of Light Shelves and Controlling Solar Heat Gain
Authors: Masoud Shadan , Zamani Zahra , Hosseini Seyed Morteza , Attia Shady
Published: June 2024

In areas with a deep floor plan, the distribution of natural light is not uniform. Consequently, relying solely on daylight may not suffice to meet the space’s lighting requirements, necessitating the use of artificial lighting in darker areas. Therefore, a lighting system is needed that not only controls the glare near the windows but also increases the light at the end of the room and provides uniform daylight. One of the widely used systems is the “light shelf”, which has three main functions: shading, increasing the depth of light penetration, and reducing glare. Review articles about light shelves were published in 2015 and 2017, while more than 80% of the studies have been carried out since 2016, and light shelves with more diverse forms and dynamic elements and many consolidations have been proposed. Therefore, there is a need for a more comprehensive review. The main question of this research is how different parameters (including climate, material, ceiling, and integrated systems) can help to increase the efficiency of light shelves. By using a systematic review, studies in the past three decades were classified in order to determine the effect of these parameters on improving lighting performance and controlling solar heat gain.
Parameter Design of a Photovoltaic Storage Battery Integrated System for Detached Houses Based on Nondominated Sorting Genetic Algorithm-II
Authors: Hou Yaolong , Yuan Quan , Wang Xueting , Chang Han , Wei Chenlin , Zhang Di , Dong Yanan , Yang Yijun , Zhang Jipeng
Published: June 2024

With the deteriorating environment and excessive consumption of primary energy, solar energy has become used in buildings worldwide for renewable energy. Due to the fluctuations of solar radiation, a solar photovoltaic (PV) power system is often combined with a storage battery to improve the stability of a building’s energy supply. In addition, the real-time energy consumption pattern of the residual houses fluctuates; a larger size for a PV and battery integrated system can offer more solar energy but also bring a higher equipment cost, and a smaller size for the integrated system may achieve an energy-saving effect. The traditional methods to size a PV and battery integrated system for a detached house are based on the experience method or the traversal algorithm. However, the experience method cannot consider the real-time fluctuating energy demand of a detached house, and the traversal algorithm costs too much computation time. Therefore, this study applies Nondominated Sorting Genetic Algorithm-II (NSGA-II) to size a PV and battery integrated system by optimizing total electricity cost and usage of the grid electricity simultaneously. By setting these two indicators as objectives separately, single-objective genetic algorithms (GAs) are also deployed to find the optimal size specifications of the PV and battery integrated system. The optimal solutions from NSGA-II and single-objective GAs are mutually verified, showing the high accuracy of NSGA-II, and the rapid convergence process demonstrates the time-saving effect of all these deployed genetic algorithms. The robustness of the deployed NSGA-II to various grid electricity prices is also tested, and similar optimal solutions are obtained. Compared with the experience method, the final optimal solution from NSGA-II saves 68.3% of total electricity cost with slightly more grid electricity used. Compared with the traversal algorithm, NSGA-II saves 94% of the computation time and provides more accurate size specifications for the PV and battery integrated system. This study suggests that NSGA-II is suitable for sizing a PV and battery integrated system for a detached house.
Financial Policies for Single-Person Household Housing in South Korea
Authors: Jeon Seran , Lee Myounghoon , Kim Seiyong
Published: June 2024

We investigated the determinants of awareness, utilization, and satisfaction regarding financial aid programs for single-person households in South Korea and proposed policy enhancements. Our analysis employed logistic regression on microdata from the “2020 Housing Survey” by Statistics Korea, covering the nation and all age groups. We categorized single-person household traits affecting program awareness, utilization, and satisfaction into demographic, socio-economic, housing, and housing perception factors. The dependent variables included awareness, utilization status, and satisfaction levels of government-sponsored financial support programs, which were measured on a four-point Likert scale. The independent variables encompassed demographic, socio-economic, and housing characteristics, which were analyzed comprehensively. We identified factors that influenced awareness, utilization, and satisfaction and recommended tailored policy measures. The findings revealed lower awareness among elderly individuals, women, rural residents, and rental households. Moreover, older age, lower income, rental, and one-room dwelling households exhibited lower utilization rates, with decreased housing and residential environment satisfaction correlating with diminished program satisfaction. Due to the diverse characteristics of single-person households, strategic interventions are crucial. Measures to bridge information gaps, establish comprehensive long-term support systems, and develop differentiated policies tailored to single-person household traits are imperative for improving financial aid programs for this demographic.
Multi-Dimensional Iterative Constitutive Model of Concrete under Complex Stress Conditions in Composite Structures
Authors: Rong Chong , Duan Zhipeng , Tang Jun
Published: June 2024

In composite structures or complex concrete members, some concrete bears multiple forces, called core concrete. The properties of the core concrete are variable under complex stress conditions, which will influence the structure performance analysis. Therefore, it is necessary to establish an accurate and theoretical constitutive model of concrete under complex stress conditions. The elastic–plastic properties of concrete in complex stress conditions were analyzed first. Then, the failure criterion of concrete in complex stress conditions was discussed to identify the key parameters. And the relationship between the stress–strain curve and failure criterion was analyzed through mathematical derivation. Finally, the multi-dimensional iterative constitutive model of concrete under complex stress conditions was established and verified. Based on the analysis results, the concrete under multi-axial stress conditions shows a spindle-shape stress envelope diagram. The failure criterion should be established by the analysis of concrete under high multi-axial compression conditions, tension–compression conditions, and shear–compression conditions. The plastic modulus is the key to reflecting the plastic strain development trend and the stress–strain relationship.
Evaluation of Critical Thresholds for Surrounding Rock Stability in TBM Tunnels Utilizing Limit State Analysis
Authors: Guo Fawang , Yu Xiaoxuan , Shi Yipeng , Shen Chunyong , Zhu Baoqiang , Peng Hao , Zhou Haizuo
Published: June 2024

The safety and stability of tunnel construction are paramount concerns in tunnel engineering. Traditionally, the assessment of tunnel stability involves evaluating whether tunnel displacement and deformation velocities exceed acceptable thresholds, using specifications and analogical reasoning. However, standardized cautionary indicators often lack adaptability and can result in unnecessary reinforcement and increase economic costs. This study presents a method for determining limit displacement and deformation velocities based on tunnel deformation limit states. Based on the finite difference method, which considers the quality of surrounding rock mass and tunnel geometric configuration, a parametric analysis of these velocities is presented. The vault settlement, relative spandrel displacement, relative hance displacement, and deformation velocity are investigated to establish the thresholds for displacement and deformation velocities. Furthermore, a sensitivity analysis using a multivariate adaptive spline regression model is performed to measure the parameter effects on the early allowance values. Finally, a response surface method is developed to estimate the indicators in order to provide criteria for assessing and warning about surrounding rock stability. The obtained results show that the proposed limit state analysis method is effective for providing a standardized criterion for tunnel excavation, and the sensitivity analysis indicates tunnel depth as the most influential factor on tunnel reliability.
Challenges and Strategies for Achieving High Energy Efficiency in Building Districts
Authors: Chen Xiaoting , Vand Behrang , Baldi Simone
Published: June 2024

Achieving climate neutrality requires reducing energy consumption and CO2 emissions in the building sector, which has prompted increasing attention towards nearly zero energy, zero energy, and positive energy communities of buildings; there is a need to determine how individual buildings up to communities of buildings can become more energy efficient. This study addresses the scientific problem of optimizing energy efficiency strategies in building areas and identifies gaps in existing theories related to passive design strategies, active energy systems, and renewable energy integration. This study delineates boundaries at the building and community scales to examine the challenges of attaining energy efficiency goals and to emphasize the intricate processes of selecting, integrating, and optimizing energy systems in buildings. The four boundaries describe: (B1) energy flows through the building envelope; (B2) energy flows through heating, ventilation, air conditioning and energy systems; (B3) energy flows through individual buildings; (B4) energy flows through a community of buildings. Current theories often treat these elements in isolation, and significant gaps exist in interdisciplinary integration, scalable frameworks, and the consideration of behavioral and socioeconomic factors. Achieving nearly zero energy, zero energy, and positive energy communities requires seamless integration of renewable energy sources, energy storage systems, and energy management systems. The proposed boundaries B1–B4 can help not only in analyzing the various challenges for achieving high energy efficiency in building communities but also in defining and evaluating these communities and establishing fair methods for energy distribution within them. The results demonstrate that these boundaries provide a comprehensive framework for energy-efficient designs, constructions, and operational practices across multiple buildings, ensuring equitable energy distribution and optimized performance. In addition, the definition of boundaries as B1-B4 contributes to providing an interface for energy-efficient designs, constructions and operational practices across multiple buildings.
Disentangling the Modifiable Areal Unit Problem in Housing Density and Price Associations
Authors: Cheung Ka-Shing , Sham Chiu-Wing , Yiu Chung-Yim
Published: June 2024

Urban planning education must address the Modifiable Areal Unit Problem (MAUP) to comprehend the critical impact of urban density on sustainable city development. Quantitative studies using administrative area units face indefinite aggregate level biases. This paper introduces an efficient block-searching method to calculate property densities around residences of various boundary scales and empirically examines their relationship with housing prices in Auckland, New Zealand. Results reveal negative associations between housing prices and densities within neighbourhoods, emphasising the limitations of administrative boundaries. These findings underscore the necessity for planning education to navigate MAUP’s complexities in shaping urban development policies.
Parametric Modeling and Numerical Simulation of a Three-Dimensional Random Aggregate Model of Lime–Sand Piles Based on Python–Abaqus
Authors: Yuan Jia , Si Jianhui , Qiao Yong , Sun Wenshuo , Qiao Shibo , Niu Xiaoyu , Zhou Ming , Ju Junpeng
Published: June 2024

A lime–sand pile is a three-phase particle composite material composed of a lime matrix, sand, and a loess aggregate at the meso level. Establishing a random aggregate model that can reflect the actual aggregate gradation, content, and morphology is the premise of numerical simulations of the meso-mechanics of lime–sand piles. In this paper, the secondary development of Abaqus 2022 is realized by writing Python 3.12 scripts, and a parameterized three-phase mixed lime–sand pile random meso-spherical aggregate model is obtained. A meso-modeling idea of lime–sand piles is creatively proposed, the integrated-generation algorithm of a spherical aggregate of different materials is written, and the material’s properties and mesh generation are given by the algorithm. Finally, a numerical simulation of temperature–expansion statics is carried out using an established mesoscopic model. Under different mixing ratios, the expansion force increases with an increase in the lime proportion. The increase in the expansion force is approximately 45% of that without an increased lime proportion. The simulated expansion forces are 8.81 kN, 12.61 kN, and 18.89 kN, respectively, which are similar to the experimental results for laboratory specimens, and the relative error is less than 3%. In the case of different height ratios, with increases in height, the change in the expansion force is very small, and the relative error between the simulated value and the experimental value is less than 2%, which further verifies the reliability of the mesoscopic random model of lime–sand piles. The model can be used to guide the practical application of engineering.
Audiological Outcomes of Weekly vs. Triweekly Cisplatin in Head and Neck Cancer with Cochlear-Sparing Intensity-Modulated Radiation Therapy
Authors: Gamez Mauricio E. , Blakaj Dukagjin M. , Bhateja Priyanka , Custer Amy , Klamer Brett G. , Pan Jeff , Gogineni Emile , Baliga Sujith , Bonomi Marcelo R.
Published: June 2024

Cisplatin, one of the most ototoxic anti-neoplastic agents, causes permanent hearing loss in up to 90% of patients. We assessed ototoxicity rates and prospectively collected audiologic outcomes of patients receiving low-dose or high-dose cisplatin with concurrent cochlear-sparing intensity-modulated radiation therapy (IMRT). Patients with head and neck squamous cell carcinoma (HNSCC) receiving definitive or adjuvant cisplatin-based chemoradiotherapy (CRT) were analyzed. Cisplatin was administered either in low doses weekly (40 mg/m2) for up to seven doses or in high doses triweekly (100 mg/m2) for up to three doses. Cochlear-sparing IMRT was delivered in all cases. Audiologic data were prospectively collected before, during, and after treatment completion. The primary endpoint was a hearing change grade of ≥3 after CRT completion. Of the 96 HNSCC patients evaluated, 69 received weekly cisplatin and 58 received definitive CRT. Of patients receiving weekly cisplatin, 13% developed ≥G3 ototoxicity vs. 56% of patients who received triweekly cisplatin (p < 0.001). In multivariable modeling, the cisplatin dose schedule remained significant (OR: 8.4, 95%CI: 2.8–27.8, p < 0.001) for risk of severe irreversible ototoxicity. Triweekly cisplatin CRT significantly increased the ≥G3 severe irreversible ototoxicity risk compared to low-dose weekly cisplatin, irrespective of the cumulative cisplatin dose, even with the use of cochlear-sparing IMRT. No significant difference in oncologic outcomes was observed between the two schedules.
Enhancing Early Lung Cancer Diagnosis: Predicting Lung Nodule Progression in Follow-Up Low-Dose CT Scan with Deep Generative Model
Authors: Wang Yifan , Zhou Chuan , Ying Lei , Chan Heang-Ping , Lee Elizabeth , Chughtai Aamer , Hadjiiski Lubomir M. , Kazerooni Ella A.
Published: June 2024

Early diagnosis of lung cancer can significantly improve patient outcomes. We developed a Growth Predictive model based on the Wasserstein Generative Adversarial Network framework (GP-WGAN) to predict the nodule growth patterns in the follow-up LDCT scans. The GP-WGAN was trained with a training set (N = 776) containing 1121 pairs of nodule images with about 1-year intervals and deployed to an independent test set of 450 nodules on baseline LDCT scans to predict nodule images (GP-nodules) in their 1-year follow-up scans. The 450 GP-nodules were finally classified as malignant or benign by a lung cancer risk prediction (LCRP) model, achieving a test AUC of 0.827 ± 0.028, which was comparable to the AUC of 0.862 ± 0.028 achieved by the same LCRP model classifying real follow-up nodule images (p = 0.071). The net reclassification index yielded consistent outcomes (NRI = 0.04; p = 0.62). Other baseline methods, including Lung-RADS and the Brock model, achieved significantly lower performance (p < 0.05). The results demonstrated that the GP-nodules predicted by our GP-WGAN model achieved comparable performance with the nodules in the real follow-up scans for lung cancer diagnosis, indicating the potential to detect lung cancer earlier when coupled with accelerated clinical management versus the current approach of waiting until the next screening exam.
Unilateral Post-Chemotherapy Robot-Assisted Retroperitoneal Lymph Node Dissection for Stage II Non-Seminomatous Germ Cell Tumors: Sexual and Reproductive Outcomes
Authors: Tufano Antonio , Cilio Simone , Spena Gianluca , Izzo Alessandro , Castaldo Luigi , Grimaldi Giovanni , Muscariello Raffaele , Franzese Dario , Quarto Giuseppe , Autorino Riccardo , Passaro Francesco , Perdonà Sisto
Published: June 2024

We aimed to report sexual and reproductive outcomes following post-chemotherapy robot-assisted retroperitoneal unilateral lymph node dissection (PC-rRPLND) for non-seminomatous germ cell tumors (NSGCTs) at a high-volume cancer center. We collected records regarding sexual and reproductive outcomes of patients undergoing unilateral PC-rRPLND for stage II NSGCTs from January 2018 to November 2021. Preoperative and postoperative (at 12 months) ejaculatory function as well as erectile function, based on the International Index of Erectile Function-5 (IIEF-5) and Erection Hardness Score (EHS), were assessed. Only patients with a pre-operative IIEF-5 of ≥22 and EHS of ≥3 were included in this analysis. Overall, 22 patients undergoing unilateral PC-rRPLND met the inclusion criteria. Of these, seven (31.8%) patients presented an andrological disorder of any type after PC-rRPLND. Specifically, retrograde ejaculation was present in three (13.6%) patients and hypospermia was present in one (4.5%) patient. Moreover, three (13.6%) patients yielded erectile dysfunction (IIEF-5 < 22 and/or EHS < 3). Lastly, two (9.1%) succeeded in naturally conceiving a child after PC-rRPLND. Retrograde ejaculation is confirmed to be one of the most common complications of PC-rRPLND. Moreover, a non-negligible number of patients experience erectile dysfunction.
Extracellular Vesicle- and Mitochondria-Based Targeting of Non-Small Cell Lung Cancer Response to Radiation: Challenges and Perspectives
Authors: Leonov Sergey , Dorfman Anna , Pershikova Elizaveta , Inyang Olumide , Alhaddad Lina , Wang Yuzhe , Pustovalova Margarita , Merkher Yulia
Published: June 2024

During the cell life cycle, extracellular vesicles (EVs) transport different cargos, including organelles, proteins, RNAs, DNAs, metabolites, etc., that influence cell proliferation and apoptosis in recipient cells. EVs from metastatic cancer cells remodel the extracellular matrix and cells of the tumor microenvironment (TME), promoting tumor invasion and metastatic niche preparation. Although the process is not fully understood, evidence suggests that EVs facilitate genetic material transfer between cells. In the context of NSCLC, EVs can mediate intercellular mitochondrial (Mt) transfer, delivering mitochondria organelle (MtO), mitochondrial DNA (mtDNA), and/or mtRNA/proteinaceous cargo signatures (MtS) through different mechanisms. On the other hand, certain populations of cancer cells can hijack the MtO from TME cells mainly by using tunneling nanotubes (TNTs). This transfer aids in restoring mitochondrial function, benefiting benign cells with impaired metabolism and enabling restoration of their metabolic activity. However, the impact of transferring mitochondria versus transplanting intact mitochondrial organelles in cancer remains uncertain and the subject of debate. Some studies suggest that EV-mediated mitochondria delivery to cancer cells can impact how cancer responds to radiation. It might make the cancer more resistant or more sensitive to radiation. In our review, we aimed to point out the current controversy surrounding experimental data and to highlight new paradigm-shifting modalities in radiation therapy that could potentially overcome cancer resistance mechanisms in NSCLC.
The European Thyroid Imaging and Reporting Data System as a Remedy for the Overdiagnosis and Overtreatment of Thyroid Cancer: Results from the EUROCRINE Surgical Registry
Authors: Hellmann Andrzej Rafał , Wiśniewski Piotr , Śledziński Maciej , Raffaelli Marco , Kobiela Jarosław , Barczyński Marcin
Published: June 2024

Background: The European Thyroid Imaging and Reporting Data System (EU-TIRADS) aims to reduce the overdiagnosis of thyroid cancer (TC) by guiding the selection of nodules for fine-needle aspiration biopsy (FNAB). This study sought to validate EU-TIRADS nodule selection criteria using data from EUROCRINE, an extensive international endocrine surgery registry. Method: We reviewed indications for FNAB among patients with TC compared to those with benign disease who underwent surgery between March 2020 and March 2022, considering preoperative EU-TIRADS scores and dominant nodule size (FNAB is recommended in Category 5 (˃10 mm or ˂10 mm with suspicious lymph nodes), 4 (˃15 mm), and 3 (˃20 mm)). Patients were categorized into three risk groups: minimal risk (patients with papillary microcarcinoma), high risk (patients with pT3b stage or higher, pN1b, or pM1), and low–moderate risk (all other patients). We conducted a Receiver Operating Characteristic (ROC) analysis to assess the diagnostic accuracy of the EU-TIRADS. Results: We analyzed 32,008 operations. Approximately 68% of the surgical records included EU-TIRADS classifications. The EU-TIRADS exhibited diagnostic accuracy across high-volume sites, with a median ROC Area Under the ROC Curve (AUC) of 0.752, indicating its effectiveness in identifying malignancy. Among the cases, 7907 patients had TC. Notably, 55% of patients with TC underwent FNAB despite not initially meeting the EU-TIRADS criteria. These patients were distributed across the minimal- (58%), low–moderate- (36%), and high-risk (5.8%) categories. Of the patients with TC recommended for FNAB, 78% were deemed low–moderate risk, 21% high risk, and only 0.7% minimal risk. Conclusion: The EU-TIRADS offers effective preoperative malignancy risk stratification. Promoting the proper use of the EU-TIRADS in clinical practice is essential to mitigate the overdiagnosis and overtreatment of low-risk TC.
Mixtures of Three Mortaparibs with Enhanced Anticancer, Anti-Migration, and Antistress Activities: Molecular Characterization in p53-Null Cancer Cells
Authors: Wadhwa Renu , Yang Shi , Meidinna Hazna Noor , Sari Anissa Nofita , Bhargava Priyanshu , Kaul Sunil C.
Published: June 2024

Mortalin, a member of the Hsp70 family of proteins, is commonly enriched in many types of cancers. It promotes carcinogenesis and metastasis in multiple ways of which the inactivation of the tumor suppressor activity of p53 has been firmly established. The downregulation of mortalin and/or disruption of mortalin–p53 interactions by small molecules has earlier been shown to activate p53 function yielding growth arrest/apoptosis in cancer cells. Mortaparibs (Mortaparib, MortaparibPlus, and MortaparibMild) are chemical inhibitors of mortalin isolated by cell-based two-way screening involving (i) a shift in the mortalin staining pattern from perinuclear (characteristics of cancer cells) to pancytoplasmic (characteristics of normal cells) and (ii) the nuclear enrichment of p53. They have similar structures and also cause the inhibition of PARP1 and hence were named Mortaparibs. In the present study, we report the anticancer and anti-metastasis activity of MortaparibMild (4-[(4-amino-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-N-(4-methoxyphenyl)-1,3-thiazol-2-amine) in p53-null cells. By extensive molecular analyses of cell proliferation, growth arrest, and apoptosis pathways, we demonstrate that although it causes relatively weaker cytotoxicity compared to Mortaparib and MortaparibPlus, its lower concentrations were equally potent to inhibit cell migration. We developed combinations (called MortaparibMix-AP, MortaparibMix-AM, and MortaparibMix-AS) consisting of different ratios of three Mortaparibs for specifically enhancing their anti-proliferation, anti-migration, and antistress activities, respectively. Based on the molecular analyses of control and treated cells, we suggest that the three Mortaparibs and their mixtures may be considered for further laboratory and clinical studies validating their use for the treatment of cancer as well as prevention of its relapse and metastasis.