bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-frequency cabin noise of rapid transit trains
Authors: Lee Hsiao Mun , Lee Heow Pueh
Published: March 2024

Rapid transit or mass rapid transit (MRT) is a high-capacity public transport designed to carry a large number of passengers, especially during the peak hours. They are becoming very popular in major cities and some deem the presence of the rapid transit system in a city as a symbol of modern development and essential feature of urban life. As the rapid transit system expands, the traveling time on a rapid transit train may increase due to longer journey and cabin noise has become an environmental concern for the passengers. In the present study, we would attempt to do a more detailed study of the effect of viaduct height, in particular viaducts of different heights on the cabin noise of various rapid transit systems. The present study examined and benchmarked the cabin noise in terms of both dB(A) and dB(C) for four different rapid transit systems, namely part of the East-West line including the Tuas-West extension on elevated tracks with very high viaduct of the Singapore MRT System; part of Paris Line 2 from Anvers to Belleville station including a stretch of elevated track on viaduct; part of the Piccadilly line of London from Heathrow Airport to Green Park station with a stretch on surface ground; and finally part of Chongqing Line 3 from Gongmao to Lianglukou station across the Yangtze river. It was found that the cabin noise would be dominated by low-frequency content and would be better reflected if the measurements were presented in dB(C), especially for trains running on elevated tracks of greater height.
Boosted electrochemical properties of Co3O4 nanoflakes by the addition of a redox-additive electrolyte
Authors: Murugan Anbazhagan , Siva Vadivel , Shameem Abdul samad , Pannerselvam Maruthasalam , Kim Ikhyun , Al-Sehemi Abdullah G. , Sivaprakash Paramasivam
Published: March 2024

Metal oxide-based electrode materials and redox additive electrolytes hold great promise as essential components of energy storage devices and have a great impact on their overall performance. Co3O4 nanoflakes (NFs) have been prepared by a simple hydrothermal method. After thorough characterization of structure, functional group, and surface morphology, the potential of the as-prepared Co3O4 NFs is assessed as an electrode material for a supercapacitor. The powder XRD analysis confirms the formation of the spinel cubic phase and space group Fd

3
‾

$\bar{3}$

m. Morphological studies showed prepared Co3O4 having nanoflakes-like structures and, with analysis by EDX, the presence of elemental composition has been confirmed. The electrochemical performance of the Co3O4 electrodes has been studied in three electrode configurations using a redox-additive electrolyte. The electrode demonstrates enhanced supercapacitor performance with a redox additive electrolyte due to the reversible oxidation states of Co2+/Co3+ and Fe2+/Fe3+, which significantly reinforced the Faradaic redox reaction. The CV curve has maintained its shape even at all scan rates, confirming the outstanding rate capability of the electrode. The Co3O4 electrode showed a greater specific capacitance (C
sp) of 611.16  F g−1 at a current density of 10 A g−1 in a redox additive electrolyte solution and capacitance retentions up to 69.23 % after 10,000 cycles. The calculated charge transfer resistance (R

ct
) of before and after GCD 10,000 cycles is obtained. The overall performance of the electrode material being consider as a promising candidate for supercapacitor applications.
Történeti áttekintés. A magyarországi drogrehabilitációs intézmények működésének szakpolitikai háttere
Authors: Molnár Dániel
Published: March 2024

A tanulmány a drogrehabilitáció témakörének megjelenését vizsgálja a drogpolitika szempontjából releváns stratégiai dokumentumok felhasználásával. A rendszerváltást megelőző időszak, majd a '90-es meghatározó jelentőségű szakpolitikai dokumentumainak áttekintését követően részletesen foglalkozunk a 2000-ben elfogadott Nemzeti stratégia a kábítószer-probléma visszaszorítására című dokumentum drogrehabilitációt érintő részeivel, illetve a stratégiai program értékelésével. A tanulmányban ismertetjük az Országgyűlés által 2009-ben és 2013-ban elfogadott drogstratégiák drogrehabilitációt érintő célkitűzéseit.
A terápiás közösségek értékelésének kérdései
Authors: B. Erdős Márta , Kelemen Gábor , Szijjártó Linda
Published: March 2024

Tanulmányunkban először a terápiás közösségek (TC)eredményértékelésének problémáit tekintjük át. Az eredmények értékeléseazért jelent különös nehézséget, mert a szokásos módszerek nemműködnek a TC-k komplex és individualizált környezetében. A terápiás sikermérése, de még meghatározása is problémát jelenthet. A szerzők újnézőpontot javasolnak, felfogásukban a terápiás siker nem más, mint egykészség kialakítása a józanság élethosszig tartó tanulására. Ezzelösszefüggésben áttekintenek néhány konkrét módszert az identitás és azattitűdök változásának mérésére. A folyamatértékelés a legtöbb terápiáskörnyezetben természetes hangsúlyt kap. A folyamatértékelésben akvalitatív technikáknak, az etnográfiai jellegű kutatásoknak lehet nagyszerepe.
A felépülés folyamata és értékelése kliensek, valamint segítőik részéről
Authors: B. Erdős Márta , Szijjártó Linda , Márk Mónika , Madácsy József , Mihaldinecz Csaba
Published: March 2024

A szerzők a felépülés folyamatait és perspektíváit terápiás közösségek korábbi és jelenlegi klienseinek, valamint segítőinek bevonásával vizsgálják. Tartós felépülésben és a felépülés korai szakaszában lévő személyekkel, főként polidrog-használókkal interjúztak. A kritikus incidenselemzés módszerét hivatásos („normi”) és/vagy tapasztalati (felépülő függő) segítő szakemberekkel készült interjúkban alkalmazták. A kiilleszkedő szerhasználó útja a „számkivetett” állapottól vezethet a terápiás közösségbe való befogadásig. A mélypont tapasztalata gyakori, de nem feltétele a józanság felé tett lépéseknek. A terápiás közösség biztonságos környezetet nyújt, amely elősegíti a szociális tanulást, a felépülésért való fokozatos felelősségvállalást, miközben megkérdőjelezi a korábbi identitáselemeket. A segítők saját élettapasztalata és közöskölcsönös fejlődésre való hajlandósága a siker fontos feltétele. Problémát jelent, ha egy kliens idő előtt hagyja el a közösséget – ezeknek az eseteknek a tanulmányozása hozzájárulhat a terápiás programok továbbfejlesztéséhez.
Individuals with Nazi and Nazi-Sympathizer Family History: Psychotherapeutic Issues
Authors: Wieland-Burston Joanne
Published: March 2024

This article presents the findings of an ongoing supervision group (founded in 1999) researching the after-effects of the Nazi period on people in psychotherapy in Germany today. The unacknowledged collective shadow hidden behind half-truths, prevarications, and silence itself prevents a genuine working through of the Nazi past. Patients’ lack of knowledge concerning their families’ own past leads to unconscious guilt, which often then leads to psychosomatic disturbances. But this is not only a problem in Germany. Unacknowledged collective shadows are prevalent in many countries worldwide. Psychological difficulties on the individual and societal levels result.
The End of Evolution
Authors: Brockman Richard
Published: March 2024

Charles Darwin's theory of evolution was founded on the core belief that natural history is one of slow, incremental change, a concept he called “speciation.” A hundred years later Eldredge and Gould challenged Darwin's theory, arguing that the data of paleontology reveals something quite different: long periods of stasis followed by bursts of change, a concept they called “punctuated equilibria.” This article will follow that progression and then describe the three punctuated equilibria that I believe led to Homo sapiens. I argue that two of the three transitions are revealed in the hard data of the fossil record. The third is in the soft tissue of the brain. This third punctuated equilibrium placed Homo sapiens outside of evolution. Its arrival, 50,000 years ago, marked the beginning of the end of evolution.
Aggression in Psychodynamic Psychotherapy and Supervision: Becoming a More Effective Therapist
Authors: Shapiro Elizabeth L.
Published: March 2024

Access to one's healthy aggression is critical for both patient and therapist. On the patient's end, the ability to access and modulate aggression is fundamental to the establishment of healthy self-esteem and the capacity to sustain relationships and pursue life goals. On the therapist's end, access to aggression allows for the setting of a secure therapeutic frame and the subsequent conduct of the deep work of therapy. Conversely, lack of access to aggression creates burdensome and problematic situations that may subvert the treatment. Beginning therapists have a particular susceptibility to minimize their own aggression given certain factors in their choice of profession. Supervisors’ modeling of the experience of aggression, as well as the provision of a safe atmosphere in which new clinicians become comfortably aware of their own and their patients’ aggression, will help fortify beginning therapists’ capacity to harness their aggression in the service of the work.
EMENDAS IMPOSITIVAS MUNICIPAIS
Authors: Carvalho Valladão Nogueira Villela Lucila , Augusto Ferreira Giovanni , Leal Roger , Roberto Caríssimo Cláudio
Published: March 2024

O objetivo deste artigo é analisar os principais impedimentos de ordem técnica à execução das emendas impositivas ao orçamento de 2022 do município de Três Corações/MG. Para tal propósito, constrói-se um teórico a partir do conceito de planejamento e orçamento público no Brasil. Em seguida apresenta-se a discussão teórica sobre as naturezas impositiva e autorizativa do orçamento público sob a ótica do poder legislativo e por fim, aponta os impedimentos legais à execução orçamentária e financeira das emendas impositivas individuais. É estudado o caso do município de Três Corações a partir de uma análise documental empregando a estatística descritiva. Os fatores em evidência nos resultados são a ausência de individualização e instrumento jurídico não permitido, enquanto questões relacionadas à regulamentação e valor insuficiente, mesmo que não apareçam com a mesma frequência, podem ser consideradas barreiras importantes. A principal conclusão desta pesquisa é que há uma qualidade questionável na elaboração dos projetos de autoria dos vereadores do município para os recursos de emendas.
GESTÃO DEMOCRÁTICA NAS IFES
Authors: Dantas Diniz Isca , Silva Napie
Published: March 2024

Este artigo analisa a perspectiva dos ocupantes de cargos de direção do Instituto Federal de Educação Tecnológica do Rio Grande do Norte, quanto à inovação de se estabelecer eleições para todos os ocupantes destes cargos. A pesquisa foi realizada como estudo de caso descritivo explicativo, fundamentada em revisão de literatura sobre os temas de ocupação de cargos de confiança e gestão democrática. Para tal, foram aplicados questionários com uma amostra de servidores ocupantes de cargos de direção contendo questões estruturadas e não estruturadas. Os resultados indicaram que, apesar de haver uma razoável aceitação à iniciativa, ficou evidente o receio em relação aos problemas que podem prejudicar a gestão da instituição. Verificou-se também a ausência de elementos que comprovem que efetivamente essa iniciativa gera maior grau de comprometimento da comunidade acadêmica com a gestão da instituição.
The European Union’s Strategic Test in Ukraine
Authors: Smith Karen E.
Published: March 2024

Russia’s ongoing invasion of Ukraine is the most severe challenge that the European Union faces. The EU has generally responded in a united and robust manner, overcoming the clash of national interests that had previously characterized its policymaking vis-à-vis Russia. The most transformative and significant decision that the EU has made is to treat Ukraine as a candidate for EU membership. However, cracks have appeared in the EU’s unity, and the enlargement process will be long and difficult—and it could be derailed if Ukraine’s territorial integrity is not restored. That will depend on increased European efforts and continued US military assistance to Ukraine, neither of which appear certain.
France’s Identity Crisis
Authors: Chabal Emile
Published: March 2024

While many other democracies in the world celebrate or simply tolerate public expressions of difference, France has traditionally remained hostile toward them in the name of republican universalism. The rise of identity politics in recent decades, however, has posed a serious challenge to this position. Today, France is torn between republican values that do not reflect the complexity of a multicultural society, and a global culture war that has supercharged local disagreements and polemics.
The Nordic Countries Face a Colonial Reckoning
Authors: Andersen Astrid Nonbo
Published: March 2024

In recent years, all four Scandinavian countries have been urged to reckon with their histories of dominion over and injustices committed against Arctic Indigenous Peoples and Finnic-speaking minorities on their territories. Within the past six years, truth commissions and historical inquiries have been set up in all four. With a special focus on public history and different parts of the former Danish colonial realm, this article examines both the long-term and short-term histories of injustices in Scandinavia and Greenland, and how indigenous and minority representatives have pushed governments and parliaments to act.
Transformation Processes toward Low-Impact Pleasure
Authors: Wennerscheid Sophie
Published: March 2024

Taking Karen Blixen’s short story “Babette’s Feast” (1950) as the starting point of reflection, this article examines the role of culinary pleasure in relation to social and environmental transformations. Combining literary criticism and food studies, the article explores the transformative potential of culinary art both as it is represented in the literary text and as it might affect people in real life. While Blixen in her story makes the case for culinary pleasure as an experience of abundance and extravagance, the article argues that we need to rethink pleasure according to sustainability criteria, including frugal practices. By presenting a method that engages in processes of change by both examining a literary food text and reflecting on a cooking workshop as a speculative exercise on how to create low-impact pleasure, this contribution seeks to introduce an integrated approach to literary criticism, food studies, and socioecological transformation.
Remaking the Qualities of Turkish Olive Oil
Authors: Silverstein Brian
Published: March 2024

The geography that is now Turkey has produced olives and their oil for millennia, but major changes in the industry have been underway in the last decade, with many producers now focusing on quality over quantity. Based on fieldwork with olive oil producers, harvesters, laboratory technicians, equipment engineers, and others in the industry, this article describes this “quality turn,” what is driving it, who is involved in it, how it unfolds, and what its effects are. Some of the players involved in producing olive oil in Turkey for decades or longer have witnessed important generational changes, including more women entering the sector and technological innovation. Prominent roles are now played by laboratories and tasting competitions, involving the recalibration of human sense perceptions on the part of producers (and, more slowly, consumers) to be commensurate with international standards for defining target aroma profiles in olive oil.
Individual and Collective Karma in the Works of Thích Nhất Hạnh
Authors: Soucy Alexander
Published: March 2024

The version of Buddhism put forward by Thích Nhất Hạnh in his writing and teaching has led some scholars and Buddhist practitioners to question whether he is representative of Vietnamese Buddhism. This essay asserts that while Thích Nhất Hạnh’s framing of Buddhist doctrine was highly influenced by globalized Buddhist currents, it cannot be separated from the Vietnamese context from which he emerged. Through an examination of Thích Nhất Hạnh’s writings about collective karma [cộng nghiệp], this essay shows that his ideas of karma overlap with common understandings of karma in Vietnam, which see karma as being shared in the community and especially in the family. This view of karma stands in contrast to the individualism that is central to the modernist framing of Buddhism.
Insulin autoimmunity associated with vitiligo: a rare case presentation
Authors: Kuruvilla Presoon , John Angel , Murali Ashith
Published: March 2024

Insulin autoantibody syndrome (IAS) or Hirata’s disease is a rare condition characterized by recurrent fasting hypoglycaemic and postprandial hyperglycaemic episodes. Insulin autoantibodies are diagnostic for the condition. Hirata’s disease has been seen to be associated with other autoimmune conditions. Vitiligo is a common depigmentation disorder whose exact cause is unknown but thought to have an autoimmune aetiology. Although autoimmunity plays a role in the pathogenesis of both the diseases, association between the two has not been reported till date. In our case, a 72-year-old Indian woman with vitiligo for the past 30 years presented with recurrent episodes of fasting hypoglycaemia. She was found to have very high levels of fasting insulin, C-peptide, and insulin antibody and was diagnosed with IAS. Thus, we conclude that the clinical spectrum of Hirata’s disease has to be taken as more heterogenous than previously assumed.

Learning points

Insulin autoantibody syndrome (IAS) or Hirata’s disease is a rare condition characterized by recurrent fasting hypoglycaemic and postprandial hyperglycaemic episodes in which insulin plays a major role.

Insulin autoantibodies are diagnostic for IAS. The endocrine insulin and its autoantibodies play a major role in the pathogenesis of the disease.

Vitiligo is a common depigmentation disorder whose exact cause is unknown but thought to have an autoimmune aetiology.

IAS and vitiligo are two diseases with autoimmune aetiology which has been seen to be associated with each other (the first case to be reported).

The clinical spectrum of Hirata’s disease has to be taken as more heterogenous than previously assumed.

On dealing with autoimmune diseases, we should also keep in mind about other diseases with autoimmune pathogenesis.
Successful treatment of dumping syndrome with diazoxide in an infant with hypoplastic left heart syndrome
Authors: Aldawsari Khalifah A , Mattos Claudia , Khan Danyal M , Beckett Omar , Pagan Pedro
Published: March 2024

Dumping syndrome is a rare but potentially serious condition that causes inappropriate postprandial hyperinsulinemia leading to hypoglycemia in children following gastrointestinal surgeries. While dietary modifications are often the first line of treatment, severe cases may require pharmacological intervention to prevent severe hypoglycemia. We present a case of successful treatment of dumping syndrome with diazoxide. A 2-month-old infant with left hypoplastic heart syndrome who underwent single ventricle palliation pathway and developed feeding intolerance that required Nissen fundoplication. Postprandial hypoglycemia was detected following the procedure, with glucose level down to 12 mg/dL, and the diagnosis of dumping syndrome was established. The patient was successfully managed with diazoxide, which effectively resolved postprandial hypoglycemia without any major adverse events. The patient was eventfully weaned off the medication at the age of 5 months. This case highlights the potential role of diazoxide in the management of pediatric patients with postprandial hyperinsulinemic hypoglycemia secondary to dumping syndrome.

Learning points

Dumping syndrome is a possible complication of gastrointestinal surgeries and should be suspected in children with abnormal glucose levels.

Postprandial hyperglycemia should be monitored closely for significant subsequent hypoglycemia.

Diazoxide might be considered as part of the treatment plan for dumping syndrome.
Formative Assessment: A Significant Facilitator of Student Learning
Authors: Yang Yaodong
Published: March 2024

In recent decades, formative assessment has garnered substantial interest of teachers and educational researchers. Definitions of formative assessment vary in the literature. Relatively well-accepted among them is the one that describe it as the process of seeking and interpreting evidence for learners and their teachers to determine where the learners are in their learning, where they need to go and how best to get there (Antoniou & James, 2014). As opposed to summative assessment, formative evaluation gives comprehensive evaluation and feedback throughout the learning process of students, with the purpose of assisting students in identifying learning gaps, modifying learning methods, and enhancing learning outcomes. Common forms of formative assessment include quizzes, observation records, face-to-face conversations, questionnaires, feedback, student self-assessment, etc. It is meant to evaluate not only students’ academic performance but also their progress in learning attitudes, learning strategies, emotional skills, and other aspects (Wu, 2023).
The Ethical Challenges of Educational Artificial Intelligence and Coping Measures: A Discussion in the Context of the 2024 World Digital Education Conference
Authors: Chen Hong
Published: March 2024

Artificial intelligence (AI), as the core technology of the fourth industrial revolution, has been widely deployed in many areas, bringing tremendous changes to human society. At the same time, AI has also instigated a variety of ethical issues regarding basic human rights, social order, private safety, and more. In order to maintain a balance between technological development and the ethics of AI, governments of various countries and international organizations are working to develop AI regulations and ethical norms. A forum themed “Artificial Intelligence and Digital Ethics” was held as a side event during the 2024 World Digital Education Conference (WDEC), showcasing the Chinese government’s adherence to the ethical notion of “human-centered AI” and the principle of “digital for good” in using AI in digital education. The forum emphasized the importance of establishing the ethics of educational AI for circumventing relevant ethical risks and creating healthy environments for the digital transformation of education. Based on the forum’s theme, this article seeks to set forth the necessity of formulating a code of ethical norms for educational AI and to explore pathways to building an ethical framework in this regard in order to provide insights into the rational application of AI in education and promote the sustainable development of digital education.
Future Directions in Calendering Research
Authors:   Paprican Pointe-Claire, QC, Canada, Browne T.C. , Crotogino R.H. ,   Paprican Pointe-Claire, QC, Canada
Published: March 2024

Calendering is the papermaker’s last chance to reduce thickness variations along the length and width of the finished sheet, and to improve the sheet smoothness. A smoother sheet results in improved print quality, while more uniform thickness profiles improve the winding process. The calendering operation thus improves the quality of the finished product. In recent years there has been an increase in the loads, speeds and temperatures at which soft-nip calenders, whether on or off line, can be operated without mechanical failure of the cover; the result has been an improvement in the surface and printing properties achievable with mechanical printing grades of paper, and an increase in the production rates which can be sustained. As a result, these calenders have slowly replaced traditional machine calenders in new and retrofit installations. The best available design and trouble-shooting tools for modern machine calenders are based on empirical models, whose coefficients have not been related to fundamental paper or fibre properties. New furnishes therefore require experimental determination of these coefficients, and extrapolation to new calendering conditions involves some risk. As well, there are no published models, empirical or otherwise, for the design and troubleshooting of soft-nip calenders, an unfortunate state of affairs given the increased number of installations of these machines. The purpose of this review is to outline the current understanding of the process, and to identify areas where further research could be useful to allow better prediction of paper properties arising from a change in the equipment or operating conditions.
Gingival recession: how to choose the best surgical technique?
Authors: Cunha Fabiano , Lima Costa Barcellos Giovanna , Ruben Caramello Carlos , José Verges Juan , Aparecida Gonçalves de Melo Cunha Maria
Published: March 2024

Objective: to present the main decision -making criteria when choosing a surgery technique for the most variety forms of gingival recession. Data sources: A bibliographic review was carried out with a search in the database: VHL Odontologia, Scielo and Pubmed on the subject. Data synthesis: the fundamental criteria for determining the best surgery Technique I'm be used in the treatment of gingival recessions are: the classification of recessions , the location of the recession ( maxilla or mandible ), the fact that it is single or multiple , the presence or absence of keratinized apical or lateral gingiva _ the recession, the thickness characteristic of the periodontal (periodontal biotype) and the skill of the operator. Conclusions: the choice of surgery technique, with the objective of root coverage, must follow a careful assessment of clinical findings, diagnosis and operator skill. This increases the predictability of success of the surgery therapy I'm be used.
Ethical and Legal Issues Surrounding Genetic Testing in the NICU
Authors: Callahan Katharine P. , Clayton Ellen W. , Lemke Amy A. , Chaudhari Bimal P. , Wenger Tara L. , Lyle Allison N. J. , Brothers Kyle B.
Published: March 2024

Clinicians practicing in a modern NICU are noticing an increase in the proportion of patients who undergo genetic testing as well as changes in the types of genetic testing patients receive. These trends are not surprising given the increasing recognition of the genetic causes of neonatal illness and recent advances in genetic technology. Yet, the expansion of genetic testing in the NICU also raises a number of ethical questions. In this article, we will review the ethical issues raised by genetic testing, with a focus on the practical implications for neonatologists. First, we outline the complexities of measuring benefit, or utility, for neonatal genetic testing. Next, we discuss potential harms such as inequity, unexpected findings, disability biases, and legal risks. Finally, we conclude with a discussion of ethical issues related to consent for genetic testing. Throughout this article, we highlight solutions to challenges toward the ultimate goal of minimizing harms and maximizing the substantial potential benefits of genetic medicine in the NICU.
A Practical Guide to Whole Genome Sequencing in the NICU
Authors: Seither Katelyn , Thompson Whitney , Suhrie Kristen
Published: March 2024

The neonatal period is a peak time for the presentation of genetic disorders that can be diagnosed using whole genome sequencing (WGS). While any one genetic disorder is individually rare, they collectively contribute to significant morbidity, mortality, and health-care costs. As the cost of WGS continues to decline and becomes increasingly available, the ordering of rapid WGS for NICU patients with signs or symptoms of an underlying genetic condition is now feasible. However, many neonatal clinicians are not comfortable with the testing, and unfortunately, there is a dearth of geneticists to facilitate testing for every patient that needs it. Here, we will review the science behind WGS, diagnostic capabilities, limitations of testing, time to consider testing, test initiation, interpretation of results, developing a plan of care that incorporates genomic information, and returning WGS results to families.
Group A Streptococcus Infections
Authors: Bhavsar Sejal Makvana
Published: March 2024

Group A Streptococcus causes a variety of clinical manifestations, including pharyngitis and skin and soft tissue infections as well as more invasive disease. There are also multiple nonsuppurative complications of group A Streptococcus infection, including acute rheumatic fever and poststreptococcal glomerulonephritis. Pediatricians should be able to diagnose and treat the various presentations of the infection.
Síntesis de tioureas con isoniacida y niacida estructural: test frente a bacterias Gram + y Gram –
Authors: Tovar-Taboada Carlo Felipe , Angulo-Cornejo Jorge
Published: March 2024

Se han sintetizado los ligandos N-(2-nicotinoilhidrazina-1-carbonotioil)benzamida (H3L1) y su isómero N-(2-isonicotinoilhidrazina-1-carbonotioil)benzamida (H3L2) tipo N, S, O dadores, por reacción del isotiocianato de benzoilo con la hidracida nicotínica y la isoniacida respectivamente. Los ligandos H3L1 y  H3L2 fueron caracterizados por 1H-RMN ,13C-RMN, FT-IR y análisis elemental. Se ha realizado el análisis computacional utilizando las funciones de Fukui para determinar las razones por la cuales no se formaron los 1,2,4-triazoles. Se han realizado pruebas preliminares de los ligandos sintetizados frente a Staphylococcus aureus (Gram+) y Escherichia coli (Gram-),  habiéndose demostrado importante actividad frente las bacterias mencionadas.
Estudio computacional de las interacciones moleculares entre el timol y los residuos HIS41 y CYS145 presentes en el sitio activo de la proteasa 3CLpro
Authors: González Acosta José Gregorio , Parra José Gregorio , Iza Peter
Published: March 2024

La proteína proteasa 3CLpro del SARS-CoV-2 es una enzima crucial para la replicación viral, convirtiéndose en un blanco terapéutico de gran importancia. El timol (2-isopropil-5-metilfenol), un compuesto natural que se encuentra en el tomillo (Thymus vulgaris), exhibe potencial actividad antiviral contra la proteasa 3CLpro. En este estudio, usando acoplamiento molecular con AutoDockTools-1.5.6, se evaluaron las energías de interacción molecular entre el timol y los residuos de aminoácidos en el sitio activo de la proteína proteasa 3CLpro. Luego, con la teoría cuántica de Átomos en Moléculas (QTAIM) y la de Interacciones no covalentes (NCI) se analizaron los tipos de interacciones moleculares entre los residuos de aminoácidos identificados y el timol. Los cálculos cuánticos se llevaron con el software Orca-5.0.3, utilizando el método DFT con el funcional M06-2X y el conjunto base aug-cc-pVDZ en fase gaseosa. Los resultados de acoplamiento molecular indican que el timol se une a la proteína 3CL con una energía de interacción igual a -3,784 kcal/mol. El análisis QTAIM indica la presencia de puntos críticos de enlace entre el timol y los residuos HIS41 y CYS145. Además, se observa la formación de un enlace de hidrógeno entre el grupo OH del timol con el residuo CYS145, lo cual es corroborado por los análisis ELF (Electron Localization Function) y NCI (Non Covalent Interactions). Finalmente, el método NCI confirma la presencia de interacciones de van der Waals con el residuo HIS41. Los resultados sugieren que el mecanismo de inhibición de la actividad de la proteína 3CLpro es controlado por interacciones moleculares tipo puente de hidrógeno e interacciones débiles.
Avaliação do Pensamento Computacional
Authors: Cordenonzi Walkiria Helena , Cardoso Vanessa Mattoso , Corrêa Adriane Rodrigues , Oliveira Eliezer dos Santos , Del Pino Jose Claudio
Published: March 2024

O pensamento computacional (PC) tem sido tema de muitas pesquisas e, paulatinamente, está sendo incorporado aos currículos escolares da educação básica no Brasil. Porém, as investigações no que tange à forma de avaliação do pensamento computacional, bem como sua aplicabilidade na educação de adultos são ainda incipientes. Esta pesquisa objetiva apresentar quatro estudos de caso, utilizando o Modelo de Referência de Pensamento Computacional (MRPC) e um constructo andragógico, para desenvolver e avaliar as habilidades do PC em indivíduos adultos, discentes de um curso superior na área de tecnologia. Esta práxis avaliativa está ancorada no conceito de transdisciplinaridade, abarcando as áreas de filosofia, matemática e ciência da computação e, por conseguinte, a classificação dos sujeitos como Alfabetizado em Código, Letrado em Código, Pensador Computacional Desplugado ou nenhuma delas. Um dos resultados obtidos na pesquisa foi que 80% dos sujeitos foram classificados como Alfabetizados em Código, o que significa que os discentes conseguiram desenvolver as habilidades propostas no MRPC, inclusive a de programação de aplicativos móveis.
A rare case of a large tumour located under the facial nerve trunk
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Tymofieiev O.O. , Ushko N.O. ,   Shupyk National Healthcare University of Ukraine, Kyiv
Published: March 2024

Aim: to introduce a technique of total parotidectomy sparing the facial nerve branches based on a clinical case. The article presents a clinical case of a large parotid tumour located under the facial nerve trunk, the stages of its surgical removal, and the postoperative course. Parotidectomy is one of the most complicated operations in maxillofacial surgery. When performing this surgical intervention, a surgeon must observe the principles of ablastics, consider individual peculiarities of the facial nerve anatomy structure and relations of nerve and tumour, and be ready to expand the scope of the operation from subtotal to total parotidectomy. Conclusions. To improve the treatment outcomes of patients with benign parotid tumours and to reduce the number of such postoperative complications as paresis and paralysis of the mimetic muscles caused by facial nerve injury, one should know and follow the technique of parotidectomy, especially in the case of a neoplasm located under the trunk or branches of facial nerve. The research was adhered to the principles of the Declaration of Helsinki. The patient informed consent was obtained for the study. No conflict of interests was declared by the authors.
Analysis of the occurrence of postoperative cognitive dysfunction with the use of morphine hydrochloride after hip arthroplasty under spinal anesthesia
Authors:   National Pirogov Memorial Medical University, Vinnytsya, Ukraine, Svirhun M.V. , Semenenko A.I. ,   National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Published: March 2024

Purpose - to analyze the state of cognitive function of patients according to the Mini Mental State Examination (MMSE) scale in points at different follow-up periods; to establish the relationship between the occurrence of postoperative cognitive dysfunction (POCD) and a single administration of morphine hydrochloride after hip arthroplasty under spinal anaesthesia in the early postoperative period Materials and methods. The study was conducted on the basis of the Vinnytsia City Clinical Hospital of Emergency Medical Care with the participation of 120 patients. All patients were operated on for a hip fracture - hip joint replacement under spinal anesthesia. All patients in the postoperative period were evaluated for pain intensity according to the visual analog scale (VAS). In the early postoperative period, patients received: a combination of paracetamol and dexketoprofen. In case of insufficient effectiveness of paracetamol and dexketoprofen, which was assessed as the impossibility of maintaining the pain level according to VAS no more than 4 points, morphine hydrochloride 10 mg was used. The MMSE scale was used as one of the main evaluation scales for the dynamics of POCD. In this part of the work, patients were divided into two main groups depending on the dynamics of the cognitive deficit, which was determined by the MMSE scale during the entire period of observation, which generally divided the patients into two groups: «Without negative dynamics of cognitive functions» (n=85) and «With negative dynamics of cognitive functions» (n=35). Statistical processing was carried out using StatPlus programs according to parametric and non-parametric criteria, differences were considered significant at p<0.05. Results. On the 7th day after hip arthroplasty, the negative dynamics of cognitive function, compared to the data during hospitalization, remained in 68.6% of patients with morphine hydrochloride among them: in 41.6% of patients, mild cognitive disorders appeared in their absence at the stage of hospitalization, in 29.2% there was a transition from mild cognitive disorders to mild dementia and in another 29.2% - mild to moderate dementia (p=0.03). Conclusions. The obtained data indicate that 92.3% of patients who had cognitive impairment at the time of discharge from the hospital received morphine hydrochloride, which may indicate a negative effect of the use of this drug on the cognitive functions of patients with hip arthroplasty on the background of a hip fracture. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the patients was obtained for the research. No conflict of interests was declared by the authors.
Analysis of the modern treatment protocols for complicated and uncomplicated infantile hemangiomas. Literature review and own data
Authors:   Ukrainian Military Medical Academy, Kyiv, Bogomolets O.V. ,   Academy of Silesia, Katowice, Poland,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine, Hryshchenko R.V. ,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine, Pavelko M.V. ,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine, Krishchenko I.O. ,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine, Bogomolets-Sheremetieva S.O. ,   Dr. Bogomolets’ Institute of Dermatology and Cosmetology, Kyiv, Ukraine,   Bogomolets National Medical University, Kyiv, Ukraine
Published: March 2024

Infantile hemangioma (IH), a benign tumor of the vascular endothelium, is the most common type of vascular pathology of the infant’s skin, which grows and significantly increases in size mostly during the first 12 months of a child's life. Statistics indicate that IH affects up to 10% of newborns and children aged <1 year. The proliferative activity of IHs during the first year of a child's life differs significantly and could mislead parents and doctors. Lack of timely treatment at an early stage leads to an increase in the size of the tumor and high risks of cosmetic defects. Thus, the proliferation of IH can cause a gross deformation of the skin and a dysfunction of nearby organs. Purpose - to analyze modern data on the treatment of patients with complicated and uncomplicated hemangiomas, to study international experience and compare it with own observations and own experience, and to improve patient treatment protocols. In this review, we analyzed 19 articles involving more than 2400 children with different types of IH, compared different treatment protocols, their outcomes, and complications, and demonstrated our methods, results, and clinical cases. It may be resumed that β-blockers are “first-line” drugs for local and systemic treatment of IHs, as they allow slowing of the proliferation and activating resorption of the tumor without cosmetic defects or complications. Treatment of IH in babies following modern treatment protocols should be carried out non-surgically, without operations, anesthesia, scars, or cosmetic defects. Ulceration is the most common complication of IHs and the result of the late start of the treatment and thus could be prevented by the timely beginning of the therapy. No conflict of interests was declared by the authors.
DINAMIKA POPULASI IKAN KAKAP MERAH (Lutjanus malabaricus) di PERAIRAN PINRANG
Authors: Rapi Nuraeni L , Djumanto Djumanto , Murwantoko Murwantoko
Published: March 2024

Ikan kakap merah merupakan salah satu komoditas perikanan yang bernilai tinggi sebagai ikan konsumsi. Pengetahuan sebaran panjang, umur, pertumbuhan, dan mortalitas digunakan untuk mengetahui kondisi stok ikan. Penelitian ini bertujuan untuk menganalisis pertumbuhan, mortalitas, laju eksploitasi dan pola rekrutmen ikan kakap merah (Lutjanus malabaricus). Sampling dilakukan tiap bulan sekali dari April 2019 sampai Maret 2020 di perairan Kabupaten Pinrang. Contoh ikan diperoleh dari hasil tangkapan nelayan gill net,rawai dasar dan bubu. Tiap contoh ikan dilakukan pengukuran panjang menggunakan penggaris dengan ketelitian 0,1 mm. Data frekuensi panjang dianalisis menggunakan paket program FiSAT II untuk mengetahui sebaran panjang, laju pertumbuhan, mortalitas,tingkat eksploitasi dan pola rekrutmen. Total sampel ikan yang dikumpulkan selama penelitian sebanyak 916 ekor. Nilai L∞ sebesar 72,95 cm, nilai K sebesar 0,41/tahun dan nilai t0 sebesar-0,28. Laju mortalitas total sebesar 1,21, mortalitas alami (M) sebesar 0,5, mortalitas penangkapan (F) sebesar 0,71, dan Tingkat eksploitasi (E) sebesar0,59. Rekrutmen berlangsung tiap bulan dengan persentase tertinggi pada akhir musim hujan, puncak musim kemarau dan awal musim hujan. Perlu pengaturan penangkapan tentang ukuran mata pancing dan mata jaring agar tingkat eksploitasi sumberdaya ikan kakap merah berkesinambungan Red snapper is a fisheries commodity with high value as a potential export. Knowledge of the distribution of length, age, growth, and mortality is used to determine fish stocks' condition. This study analyzes the growth, mortality, exploitation rate, and recruitment pattern of red snapper (Lutjanus malabaricus). Sampling has been carried out every month from April 2019 to March 2020 in Pinrang Regency waters. Fish samples were obtained from the catch of gill net fishermen, bottom longlines, and traps. Each fish sample is measured using a ruler to a length of 0.1 mm. Long frequency data were analyzed using the FiSAT II program package to determine the length distribution, growth rate, mortality, exploitation rate, and recruitment patterns. The total fish samples collected during the study were 916 individuals. The L∞ value is 72.95 cm, the K value is 0.41 / year, and the t0 value is -0.28. The total mortality rate is 1.21, natural mortality (M) is 0.5, fishing mortality (F) is 0.71, and the exploitation rate (E) is 0.59. Recruitment occurs every month with the highest percentage at the end of the rainy season, the dry season's peak, and the beginning of the rainy season. Fishing arrangements are needed about size hook and mesh size  so that the level of exploitation of red snapper resources is sustainable.
INDEKS KEANEKARAGAMAN JENIS IKAN DEMERSAL DI LAUT ARAFURA
Authors: Nurulludin Nurulludin , Prihatiningsih Prihatiningsih , Panggabean Anthony Sisco , Taufik Muhammad , Kembaren Duranta Diandria , Mahulette Ralph Thomas , Saimroh Saimroh , Nurdin Erpind
Published: March 2024

Ikan demersal merupakan salah satu sumber daya yang memiliki potensi sangat tinggi di Laut Arafura. Informasi indeks keanekaragaman ikan demersal diperlukan setelah adanya moratorium pukat tarik di Laut Arafura. Kegiatan penelitian dilaksanakan pada tanggal 20 Oktober sampai 20 November 2018 dengan mengikuti survei sumber daya ikan di Wilayah Pengelolaan Perikanan (WPP) 718 Laut Aru dan Arafura. Analisis data menggunakan beberapa nilai indeks biodiversitas meliputi keanekaragaman jenis (species diversity), kemerataan (species evenness),  kekayaan jenis (species richness), dan dominansi jenis (species dominant). Keanekaragaman jenis dibagi dalam 3 (tiga) wilayah penelitian yaitu Timur, Barat dan  Utara Laut Arafura. Indeks Keanekaragaman Shannon Wiener (H’) ikan demersal bervariasi antara 1,26 – 2,89. Nilai indeks kekayaan jenis ikan 9,37—16,8, indeks dominansi (D) antara 0,09-0,51. Indeks kemerataan jenis dari Pielou (E) Arafura bagian timur 0,13 dan utara dengan nilai 0,24 dan perairan Arafura bagian barat nilai indeks sebesar 0,27. Nilai indeks kemerataan jenis antara 0,26-0,50. Kondisi tersebut menunjukkan adanya keseimbangan dalam pemanfaatan sumber daya ikan demersal yang ada baik dari segi pemangsaan maupun secara spasial di Laut Arafura.Demersal fish is a resource that has very high potential in the Arafura Sea. Information on the diversity index of demersal fish is needed after the moratorium on trawling in the Arafura Sea. The research activity was carried out from 20 October to 20 November 2018 by participating in a survey of fish resources in the 718 Aru and Arafura Sea Fisheries Management Area (WPP). Data analysis used several biodiversity index values including species diversity, species evenness, species richness, and species dominance. Species diversity is divided into 3 (three) research areas, namely East, West and North Arafura Sea. The Shannon Wiener Diversity Index (H') of demersal fish varies between 1.26 – 2.89. Fish species richness index value is 9.37-16.8, dominance index (D) is between 0.09-0.51. The evenness index of Pielou (E) eastern Arafura is 0.13 and north is 0.24 and the Arafura waters is 0.27. The value of the species evenness index is between 0.26-0.50. This condition shows that there is a balance in the utilization of existing demersal fish resources, both feeding habits and  spatial in the Arafura Sea.
Zarządzanie i administrowanie edukacją pozaformalną realizowaną w formie e-learningowej
Authors: Tuczyński Krystian , Warchoł Tomasz
Published: March 2024

Artykuł analizuje kwestie związane z zarządzaniem i administrowaniem edukacją pozaformalną realizowaną w formie e-learningowej. Opracowanie koncentruje się na zagadnieniach organizacyjnych związanych z edukacją pozaformalną, kładąc nacisk na kluczowe elementy, takie jak personalizacja nauki, innowacje pedagogiczne, edukacja online oraz skuteczne administrowanie. W kontekście omawiania zagadnień organizacyjnych w obszarze edukacji pozaformalnej opracowanie analizuje rolę platform e-learningowych w ułatwianiu administrowania realizacją zajęć edukacyjnych. Ponadto przedstawia strategie zarządzania procesem kształcenia przy wykorzystaniu platform e-learningowych. Wyniki przyczyniają się do pełniejszego zrozumienia skomplikowanych aspektów skutecznego zarządzania i administrowania edukacją pozaformalną w formie e-learningowej.