bluuebunny/crossref_metadata_2025 huggingface dataset:
An Image-Based Gradation Calculation Method considering Crushed Stone Morphology
Authors: Jiang Chong , Ding Xin , Pang Li , Deng Liang , Shi Zexiong
Published: July 2022

An image-based gradation calculation method considering crushed stone morphology is proposed in this paper. Eight kinds of crushed stones are prepared to figure out the effect of the particle shape on the gradation. All particles are pictured, and the photos are processed to obtain particle shape indices by using the image-based method. A minimum Feret diameter analysis method is used, which can reflect the influence of the particle shape. Then, the paper proposes a developed overall regularity to describe the morphology of particles, which is calculated by the weight of three shape indices: aspect ratio, convexity, and sphericity. The developed overall regularity is applied on gradation curve equations to provide an image-based gradation calculation method. And the provided method is validated to well fit the actual case. Furthermore, the method is also applied on two examples of gradation designation and the result proves to be feasible and practicable.
The Establishment of a Mouse Model for Degenerative Kyphoscoliosis Based on Senescence-Accelerated Mouse Prone 8
Authors: Hu Zongshan , Tang Ziyang , Kiram Abdukahar , Li Jie , Xu Hui , Xu Yanjie , Jiang Huiming , Zhu Zezhang , Qiu Yong , Liu Zhen
Published: July 2022

Objective. Degenerative kyphoscoliosis (DKS) is a complex spinal deformity associated with degeneration of bones, muscles, discs, and facet joints. The aim of this study was to establish an animal model of degenerative scoliosis that recapitulates key pathological features of DKS and to validate the degenerative changes in senescence-accelerated mouse prone 8 (SAMP8) mice. Methods. Thirty male mice were divided into 2 groups: 10 bipedal C57BL/6J mice were used as the control group, and 20 bipedal SAMP8 mice were used as the experimental group. Mice were bipedalized under general anesthesia. The incidence of scoliosis and bone quality was determined using radiographs and in vivo micro-CT images 4, 8, and 12 weeks after surgery, respectively. Histomorphological studies of muscle samples were performed after sacrifice at 12 weeks after surgery. Results. On the 12th week, the incidence rates of kyphosis in C57BL/6J and SAMP8 groups were 50% and 100%, respectively. Overall, the incidence and angle of kyphosis were significantly higher in the bipedal SAMP8 group compared to the C57BL/6J group (44.7°± 6.2° vs. 84.3°± 10.3°,

P
<
0.001

). Based on 3D reconstruction of the entire spine, degeneration of the intervertebral disc was observed in bipedal SAMP8 mice, including the reduction of disc height and the formation of vertebral osteophytes. The bone volume ratio (BV/TV) was significantly suppressed in the bipedal SAMP8 group compared with the bipedal C57BL/6J group. In addition, HE staining and Mason staining of the paraspinal muscle tissue showed chronic inflammation and fibrosis in the muscles of the bipedal SAMP8 group. Conclusions. The SAMP8 mouse model can be taken as a clinically relevant model of DKS, and accelerated aging of the musculoskeletal system promotes the development of kyphosis.
Identification of Ferroptosis-Related lncRNA Pairs for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma
Authors: Wu Congxiao , Liu Fei , Chen Haixu , Liu Qin , Song Chao , Cheng Kang , Gao Zhiyong , Fan Cheng
Published: July 2022

Background. Ferrogenesis was strongly associated with tumorigenesis and development, and activating the ferrogenic process was a novel regimen in treating cancer, especially conventional treatment-resistant cancers. The purpose of the article was to construct a ferroptosis-related long noncoding RNAs (FRlncRNAs) signature, regardless of expression levels to effectively predict prognosis and immunotherapeutic response for head and neck squamous cell carcinoma (HNSCC). Methods. The RNA-seq data for HNSCC and corresponding clinical information were obtained in the TCGA database, and ferroptosis-related genes (FRGs) were extracted in the ferroptosis database. On this basis, differentially expressed FRlncRNAs (DEFRlncRNAs) pairs were identified through coexpression analysis, differential expression analysis, and a fresh pairing algorithm. Then, a risk assessment model was established with univariate Cox, LASSO, and multivariate Cox regression analysis. Finally, we evaluated the model from various aspects, including survival status, clinicopathological characteristics, infiltration status of immune cells, immune functions, chemotherapeutic sensitivity, immune checkpoint inhibitors (ICIs)-related molecules, and N6-methyladenosine (m6A) mRNA status. Result. We established a signature of 11-DEFRlncRNA pairs related to the prognosis of HNSCC that had AUC values above 0.75 in the one-, three-, and five-year ROC curves, underscoring the high susceptibility and specifiability of predicting HNSCC prognosis. Survival rates were remarkably higher for the low-risk patients than for the high-risk patients, and the signature was significantly correlated with survival, clinical, T, and N stages. Finally, immune cell infiltration status, immune functions, chemotherapeutic sensitivity, and expression levels of ICIs-related and m6A-related molecules were statistically different among different groups. Conclusion. Our study established a novel lncRNA signature, which is independent of specific expression levels, could predict patient prognosis, and might have promising clinical applications in HNCSS.
Monitoring the Physical Condition of Basketball Players using IoT and Blockchain
Authors: Song Bo , Tuo Peixing
Published: July 2022

As a popular competitive sport, basketball has attracted the attention of many people due to its warm and sunny characteristics. Athletics means results, but not everyone gets the results they want. With the continuous development of technology, people have gradually discovered that the physical function of athletes is one of the important factors affecting the performance of sports. The long-standing principle of “three big and one small” ignores the overall physical fitness of athletes, resulting in insufficient physical coordination and slow performance improvement. Competitive sports have always followed the principle of “three big and one small,” which means emphasizing high-strength and high-intensity training, and fundamentally ignoring the impact of small muscle groups and overall physical fitness on athletes. To overcome this disadvantage, this paper aims to study the physical condition monitoring of basketball players based on the Internet of Things and blockchain. It is expected to use the Internet of Things and blockchain technology to monitor the physical function of athletes in real time, formulate scientific training plans, and improve athletes’ competition. The essence of blockchain is a decentralized database, which is used to verify the validity of messages. With the promotion of Internet technology, it is essential to store and extract information from large network information. This paper compared the results of experimental methods to show the impact of the connection between physical function training and high-level basketball traditional training, proposed a new scalable storage and privacy protection scheme to solve the problem that a large amount of data cannot be stored on the blockchain. The experimental results in this paper showed that the lowest hemoglobin content of athletes before training was 131 g/L, and the highest was 157 g/L, indicating that the athletes were generally in good physical condition at this moment. After training, the lowest hemoglobin content of athletes was 117 g/L and the highest was 131 g/L, indicating that the athlete’s physical function state declined and the training intensity was too high.
Characteristics of Tight Oil Reservoir Based on Nano-CT
Authors: Liu Zhe , Li Wenke , Li Jiajing , Wang Wei , Fu Guang
Published: July 2022

Besides biotechnology, nano-CT, the ideal technology, can also be used to observe three-dimensional nanostructures in intact cells as part of research into the characteristics of tight oil characteristics. There are few applications in the process and it is still in the early stage of development, but the advantages shown by 3D nanostructure technology are very strong and have strong applicability. Even in the face of tight oil reservoirs with poor physical properties, rapid decline in oil production after volume fracturing, and low oil recovery, it also shows very strong advantages. In order to promote the study of tight oil characteristics and avoid various problems, this article studies the characteristics of tight oil reservoirs based on nano-CT. The results show that the introduction of nano-CT technology into the study of tight oil reservoir characteristics can meet the market demand of tight oil and increase by 3.54%. It can continuously expand and develop rich oil resources under the condition of protecting geology and reservoirs, providing strong technical support for the next generation of large-scale tight oil storage and efficient growth, and can be used to a certain extent for research. The resulting reservoir characteristics solve the problem of excess resources.
Surrounding Environment and Civil Airport Fire Emergency Management Based on Big Data Simulation
Authors: Jia Jingyun , Chen Xiantao , Sun Qiang
Published: July 2022

The new generation of information and communication technologies represented by the Internet of Things, big data, and cloud computing are developing rapidly. Through continuous integration with other emerging technologies, the Internet of Things technology accelerates its penetration into the fields of smart medicine, new energy, and materials. In this article, we will explore the airport peripheral environment and civil airport fire emergency management. In airport emergency management, bird strike and fire management are the most frequent problems. Bird strikes most often occur in aircraft take-off, taxi, and landing areas. Therefore, the study of airport environmental characteristics is particularly important. In order to improve the emergency support capability of the civil airport fire department and the level of airport operation support, it is necessary to clarify the factors that affect the emergency support capability of the airport fire department. This article is based on the research of the airport surrounding environment of Big Data Internet of Things and applies it to the research of civil airport fire emergency management, which improves the emergency ability of airport firefighters.
Correlation Analysis of Positive Therapy Based on High Content Image Analysis Technology on Posttraumatic Nerve Growth in Patients with COVID‐19 in the Context of Intelligent Medical Treatment
Authors: Zheng Ting , Lin Jie , Tu Liwen , Hu Jiaying , Wei Weiping
Published: July 2022

Objective. To investigate the correlation between posttraumatic stress disorder (PTSD) and the incidence of anxiety, depression, and mental disorders in patients with novel coronavirus pneumonia. Methods. Novel coronavirus pneumonia patients in Wuhan from 2020 to April were selected for treatment from hospitals and isolation wards from 1 to April. 70 rehabilitated patients were randomly divided into the control group (35 patients) and the observation group (35 patients) who were treated with conventional therapy. Positive therapy and full perfusion therapy were introduced on the basis of conventional therapy, and the related performances of different patients were observed and evaluated. Results. The anxiety, depression, and incidence rate of related psychotic patients in the observation group after treatment were significantly reduced. Patients could maintain a good mood, increase their confidence in conquering diseases, and promote their early recovery. Conclusion. Active treatment of novel coronavirus pneumonia has positive effects on posttraumatic growth of new crown pneumonia patients, relieving anxiety and negative emotions, improving emotional control, eliminating bad emotions, actively guiding patients, and promoting psychological rehabilitation of patients.
Characterization Method of Tight Sandstone Reservoir Heterogeneity and Tight Gas Accumulation Mechanism, Jurassic Formation, Sichuan Basin, China
Authors: Jiang Lin , Zhao Wen , Zhang Benjian , Zheng Chao , Hong Feng , Hao Jiaqing
Published: July 2022

Although significant progress has been made in tight gas exploration and development, there is still a limited understanding of the gas accumulation mechanism in tight formation. The description of heterogeneity in the tight reservoir is still an obstacle during tight gas exploration. In this work, we will develop a 3D gas accumulation facility that can reflect the high temperature and pressure under the geological condition to simulate the gas accumulation process in the tight formation of the Jurassic Formation, Sichuan Basin. Both the physical experiment simulation and numerical simulation methods will be combined to reveal the mechanism of gas accumulation. The results show that (1) the permeability ratio can characterize the heterogeneity of tight reservoirs. Based on this parameter, petroleum geologists can understand the interlayer heterogeneity during fluvial deposition and predict the sweet spots of tight gas; (2) the permeability ratio relationship between hydrocarbon accumulation of the tight sandstone reservoir mainly manifests as long as there is the existence of the differential permeability and there will be differences in natural gas migration dynamics, so that the natural gas accumulates in pores and depends on the extent of source rock; and (3) although the difference between capillary force curves is at the core of the influence of the permeability ratio on the gas-bearing capacity of the “sweet spot” sand body, the permeability ratio is a parameter of practical engineering significance. This work adds new methods to tight gas formation heterogeneity characterization and sheds light on the mechanisms of hydrocarbon accumulation in tight formation.
DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a
Authors: Zhang Yaxin , Dai Jihang , Yan Lianqi , Lin Qun , Miao Haixiang , Wang Xingkai , Wang Jingcheng , Sun Yu
Published: July 2022

Osteoarthritis (OA) has been reported as a progressive disease in the elderly, primarily characterized by degenerated articular cartilage. There has been no satisfactory drug for the treatment of OA. DL-3-n-butylphthalide (NBP), a small molecule compound extracted from celery seeds, may have antiapoptotic, antioxidant, and anti-inflammatory activities in numerous studies. However, the effects of NBP on OA and its mechanisms have been rarely reported. In this study, the effect of NBP on OA in vitro and in vivo and its possible mechanism were investigated. The results showed that NBP injection into the knee joint inhibited osteoarthritis development in a rat model of osteoarthritis induced by DMM+ACLT. NBP could increase the expressions of extracellular matrix-related components (such as type II collagen, aggrecan, proteoglycan 4, and SRY-box 9) in human osteoarthritic chondrocytes and cartilage explants. Moreover, NBP promoted the expressions of SOD and CAT. NBP upregulated the expression of FoxO3a by inhibiting the PI3K/AKT pathway, which subsequently inhibited the apoptosis of human OA chondrocytes. In conclusion, NBP promotes cartilage extracellular matrix synthesis and inhibits osteoarthritis development and the underlying mechanism related to the activation of FoxO3a.
Development and Application of MOOC System for English Intercultural Communication Courses Using Neural Network
Authors: Jiang Peipei , Hou Xia
Published: July 2022

Presently, many researchers are focusing on the English intercultural communication course. However, these courses face serious challenges, such as individual student variances in conventional English cross-cultural teaching, fostering students’ cross-cultural communication abilities, and enhancing teaching quality. These problems need to be solved; therefore, this paper aims to explore the development and application of the Massive open online courses (MOOCs) system in the English cross-cultural communication course based on neural networks. Firstly, the overall function modules of the MOOC system for the English intercultural communication courses are described, with emphasis on the student function module, teacher function module, administrator function module, and system database design of the MOOC system. Second, the MOOC system’s teaching technique in an English intercultural communication course is based on a genetic algorithm, and the MOOC system’s teaching quality index in an English intercultural communication course is chosen using principal component analysis. We conducted several tests to demonstrate that the MOOC system of the English intercultural communication course using the neural network suggested in this work is resilient and may successfully increase teaching quality. The experiment proves that the MOOC system of the English intercultural communication course based on the neural network developed in this paper has efficient results as compared to existing studies. In addition, it can effectively improve the teaching quality and can train students’ intercultural communication skills and their ability to adapt to intercultural communication.
Time‐Frequency Characteristics of Ground Motion and Seismic Response Analysis of Typical Structures in the Yangbi Earthquake in Yunnan Province
Authors: Xu Qin , Chai Shaofeng , Zhou Shihu , Bao Liqun , Li Quan
Published: July 2022

The ground motion records obtained by the CDSMON during the Ms6.4 earthquake in Yangbi, Yunnan Province, on May 21, 2021, were subjected to routine processing such as baseline correction and filtering. The nonstationary time‐frequency characteristics of ground motion signals were analysed by the wavelet transform, and the acceleration response spectrum characteristics of typical stations under different epicentral distances, magnitudes, and site conditions were analysed. Finite element software was used to establish a model to analyse the seismic response of a typical three‐span continuous beam bridge. The maximum peak ground acceleration (PGA) of this earthquake (720.29 gal) was obtained from 53YBX in the NS direction at the epicentral distance of 8.6 km. The energy at station 53YBX was mainly concentrated in 0–15 Hz range, and the low‐frequency component energy caused great damage to buildings with natural frequencies in this frequency band. The Sa value near the origin of the earthquake is relatively large, as the distance from the epicentre increases, the predominant period of Sa also gradually increases, and the high‐frequency component diminishes. With the increase in earthquake magnitude, the Sa peak increased, and the long‐period component became more obvious. The soil station had more obvious long‐period components than the bedrock station, which is consistent with the amplification result of the response spectrum of overburden thickness to surface acceleration. The earthquake had little influence on the pier displacement of the three‐span continuous beam bridge with a fundamental period of 0.77 s but had a great influence on the bending moment at the bottom of the piers.
Wann hilft Belimumab bei der Lupusnephritis?
Authors: von Vietinghoff Sibylle
Published: July 2022

We performed a post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN), a Phase 3, multinational, double-blind, 104-week trial, in which 448 patients with lupus nephritis were randomized to receive intravenous belimumab 10 mg/kg or placebo with standard therapy (cyclophosphamide/azathioprine or mycophenolate mofetil). Add-on belimumab was found to be most effective in improving the primary efficacy kidney response and complete kidney response in patients with proliferative lupus nephritis and a baseline urine protein/creatinine ratio under 3 g/g. However, there was no observed improvement in the kidney response with belimumab treatment in patients with lupus nephritis and sub-epithelial deposits or with a baseline protein/creatinine ratio of 3 g/g or more. Belimumab significantly reduced the risk of kidney-related events or death and lupus nephritis flare in the overall population. Belimumab reduced the risk of a sustained 30% or 40% decline in estimated glomerular filtration rate (eGFR) versus standard treatment alone and attenuated the annual rate of eGFR decline in patients who remained on-study. Thus, our data suggest that the addition of belimumab to standard therapy could attenuate the risk of lupus nephritis flare and eGFR decline in a broad spectrum of patients with lupus nephritis. Trial registration: ClinicalTrials.gov NCT01639339
ILD: VOC-Analyse des Atemabdrucks als vielversprechende Methode der nicht invasiven Diagnostik
Authors: Drakopanagiotakis Fotios , Günther Andreas
Published: July 2022

Background: Fibrotic Interstitial lung diseases (ILD) are a heterogeneous group of chronic lung diseases characterized by diverse degrees of lung inflammation and remodeling. They include idiopathic ILD such as idiopathic pulmonary fibrosis (IPF), and ILD secondary to chronic inflammatory diseases such as connective tissue disease (CTD). Precise differential diagnosis of ILD is critical since anti-inflammatory and immunosuppressive drugs, which are beneficial in inflammatory ILD, are detrimental in IPF. However, differential diagnosis of ILD is still difficult and often requires an invasive lung biopsy. The primary aim of this study is to identify volatile organic compounds (VOCs) patterns in exhaled air to non-invasively discriminate IPF and CTD-ILD. As secondary aim, the association between the IPF and CTD-ILD discriminating VOC patterns and functional impairment is investigated. Methods: Fifty-three IPF patients, 53 CTD-ILD patients and 51 controls donated exhaled air, which was analyzed for its VOC content using gas chromatograph-time of flight-mass spectrometry. Results: By applying multivariate analysis, a discriminative profile of 34 VOCs was observed to discriminate between IPF patients and healthy controls whereas 11 VOCs were able to distinguish between CTD-ILD patients and healthy controls. The separation between IPF and CTD-ILD could be made using 16 discriminating VOCs, that also displayed a significant correlation with total lung capacity and the 6 min’ walk distance. Conclusions: This study reports for the first time that specific VOC profiles can be found to differentiate IPF and CTD-ILD from both healthy controls and each other. Moreover, an ILD-specific VOC profile was strongly correlated with functional parameters. Future research applying larger cohorts of patients suffering from a larger variety of ILDs should confirm the potential use of breathomics to facilitate fast, non-invasive and proper differential diagnosis of specific ILDs in the future as first step towards personalized medicine for these complex diseases.
Chinese Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021 Edition)
Authors: Yang Yu , Sun Juxian , Wu Mengchao , Lau Wan Yee , Zheng Shusen , Wang Xue-Hao , Chen Xiaoping , Fan Jia , Dong Jiahong , Cai Jianqiang , Chen Minshan , Chen Yongjun , Cheng Zhangjun , Dai Chaoliu , Shan Jianzhen , Du Cheng-You , Fang Chihua , Hu Heping , Ji Zhili , Jia Weidong , Li Gong , Li Jing , Li Jiangtao , Liu Chang , Liu Fubao , Ma Yong , Mao Yilei , Niu Zuoxing , Shen Jie , Shi Jie , Shi Xuetao , Song Wenjie , Sun Hui-Chuan , Tan Guang , Tao Ran , Wang Xiaohu , Wen Tianfu , Wu Liqun , Xia Jinglin , Xiang Bang-De , Yan Maolin , Ying Mingang , Zhang Ling , Zhang Xuewen , Zeng Zhao Chong , Zhang Yubao , Zhang Zhiwei , Zhou Jie , Zhou Cuncai , Zhou Jun , Zhou Ledu , Zhou Xinmin , Zhu Ji , Zhu Zhenyu , Zhang Qi , Li Qiu , Cheng Shuqun ,   on behalf of Chinese Association of Liver Cancer and Chinese Medical Doctor Association
Published: July 2022

Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. Most HCC patients are first diagnosed at an advanced stage, and systemic treatments are the mainstay of treatment. Summary: In recent years, immune checkpoint inhibitors have made a breakthrough in the systemic treatment of middle-advanced HCC, breaking the single therapeutic pattern of molecular-targeted agents. To better guide the clinical treatment for effective and safe use of immunotherapeutic drugs, the Chinese Association of Liver Cancer and Chinese Medical Doctor Association has gathered multidisciplinary experts and scholars in relevant fields to formulate the “Chinese Clinical Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021)” based on current clinical studies and clinical medication experience for reference in China. Key Messages: The consensus contained 17 recommendations, including the preferred regimen for first- and second-line immunotherapy, evaluation and monitoring before/during/after treatment, management of complications, precautions for special patients, and potential population for immunotherapy.
Molecular Detection and Genotyping of Human Cytomegalovirus in Kidney Transplant Recipients under Ganciclovir Prophylaxis in Iran
Authors: Behnezhad Farzane , Parhizgari Najmeh , Shafiei-Jandaghi Nazanin Zahra , Yavarian Jila , Mokhtari-Azad Talat
Published: July 2022

Introduction: Human cytomegalovirus (HCMV) infection is one of the most common viral complications in kidney transplant recipients. Although there are effective treatments strategies for the HCMV infection, this infection is still one of the causes of kidney transplant rejection. Methods: A total of 246 kidney transplant recipients participated in this cross-sectional study. Viral DNA was extracted from these plasma samples, and the presence of HCMV genome was determined by semi-nested PCR with specific primers for the HCMV B glycoprotein gene. Sanger sequencing analyses were carried out to determine HCMV genotypes, and the Mega x software was used for nucleotide alignment and construction of a phylogenetic tree. Results: HCMV DNA was detected in 11 (4.47%) recipients. According to the phylogenetic analysis, HCMV gB3 was 50% among kidney transplant recipients, followed by gB4 30% and gB1 20%; however, the gB2 genotype was not detected. Conclusions: This study demonstrated that the HCMV infection in our patients is relatively low because all transplant recipients received appropriate prophylaxis, thereby antiviral prophylaxis is recommended for all patients at risk of HCMV infection after kidney transplantation. Also, gB3 was the most predominant genotype among our kidney transplant recipients that was related to the higher rate of prevalence of severe HCMV infections. Moreover, an elevated serum creatinine level was detected in patients at the time of detection of HCMV infection.
Pelatihan Pembuatan Biobriket Ramah Lingkungan Berbahan Dasar Campuran Limbah Bonggol Jagung/Ampas Kopi/Serbuk Gergaji Kayu Kelompok Masyarakat Petani (GAPOKTAN) KM 12 Balikpapan Utara
Authors: Soemarsono Annisa Rahmita , Ernawati Lusi , Nafisah Azmia Rizka , Tarmidzi Fadhil Muhammad
Published: July 2022

Kebutuhan energi masyarakat yang meningkat tiap tahun masih sangat bergantung kepada energi fosil. Untuk pemenuhan kebutuhan rumah tangga masih mengandalkan minyak tanah dan gas LPG. Salah satu cara mengurangi penggunaan energi fosil adalah dengan menggunakan limbah bonggol jagung hasil kelompok masyarakat petani jagung menjadi biobriket. Biobriket merupakan salah satu sumber energi terbarukan. Limbah bonggol jagung adalah limbah padat dari hasil pertanian dan industri. Limbah bonggol jagung memiliki kandungan selulosa, hemiselulosa, dan lignin. Kadar selulosa yang tinggi pada limbah bonggol jagung dapat dimanfaatkan sebagai bahan utama penyusun biobriket. Peningkatan kualitas biobriket berbanding lurus dengan peningkatan kadar selulosa. Selain selulosa, juga dibutuhkan bahan perekat untuk mengikat matriks biobriket. Tepung tapioka dipilih menjadi bahan perekat dalam kegiatan pengolahan biobriket ramah lingkungan. Biobriket dipastikan memiliki tingkat keefektifan yang baik untuk mengurangi penggunaan energi fosil dan memiliki nilai ekonomis yang tinggi bagi produsen dan konsumen di Kalimantan Timur. Kelompok masyarakat petani Balikpapan Utara adalah salah satu kelompok petani yang kurang memiliki wawasan terkait pemanfaatan limbah pertanian menjadi produk ramah lingkungan bernilai ekonomis dan berpotensi sebagai pengganti bahan bakar, seperti biobriket. Oleh karena itu, dilakukan sosialisasi dan pelatihan pembentukan biobriket menggunakan bahan dasar limbah pertanian terhadap kelompok petani tersebut. Dengan demikian, biobriket dari kombinasi limbah bonggol jagung/serbuk gergaji kayu/ampas kopi dengan perekat tepung tapioka diharapkan dapat mengatasi kebutuhan energi bagi masyarakat pada masa yang akan datang.
Peran Kader Kesehatan Terhadap Kualitas Hidup Lanjut Usia (Lansia) Di Wilayah Kelurahan Kalibaru Kecamatan Cilincing Jakarta Utara Tahun 2018
Authors: Sastrahadi Susi Susilawati
Published: July 2022

Pertumbuhan penduduk lanjut usia di Indonesia cenderung meningkat dari tahun ke tahun. Proses penuaan merupakan kondisi alami yang tidak dapat dihindari. Menurunnya fungsi fisiologis, psikologis dan sosial yang dialami oleh lansia akan berdampak pada kualitas hidup lansia. Tujuan penelitian untuk mengetahui pengaruh kader relawan komunitas terhadap kualitas hidup pasien lansia di Kelurahan Kalibaru Kecamatan Cilincing Jakarta Utara Tahun 2018. Penelitian dilakukan dengan desain cross sectional melalui pendekatan kuantitatif. didukung oleh kualitatif. Populasi penelitian adalah seluruh lansia yang ada di wilayah kelurahan Kalibaru dengan jumlah populasi 60 lansia > 59 tahun. Pengumpulan data penelitian kuantitatif melalui wawancara terstruktur. Analisis statistik dengan uji regresi logistik. Pengumpulan data kualitatif melalui wawancara mendalam dan diskusi kelompok terfokus. Hasil penelitian menunjukkan bahwa peran kader relawan tinggi berpeluang 3,2 kali dalam meningkatkan kualitas hidup lansia baik dibandingkan peran kader rendah setelah dikontrol oleh variabel jenis kelamin, usia, pendidikan dan perkawinan (p value = 0,046; adjor = 3,23; 95% CI = 1,02-10,24). Peran kader relawan dalam peningkatan kualitas hidup lansia dimulai dengan identifikasi kebutuhan, perawatan paliatif di rumah lansia dengan pengawasan tenaga kesehatan (dokter poliklinik), kebutuhan tindak lanjut, pemberian edukasi, serta koordinasi dan administrasi. Peningkatan keterampilan kader secara terus menerus diperlukan untuk memberikan perawatan paliatif kepada lansia. Lansia terbanyak berjenis kelamin perempuan yaitu 41 orang (68,3%), kelompok usia lanjut (lansia) 60 - <75 tahun sebanyak 37 orang (61,7%), berpendidikan rendah (tidak sekolah/tidak tamat SD), yaitu 41 orang (68,3%), dan status belum kawin/duda/duda sebanyak 39 orang (65%). Sedangkan untuk peran keluarga lansia, sebagian besar lansia menyatakan peran keluarga sudah baik yaitu 43 orang (71,7%). Sebagian besar lansia menyatakan peran kader relawan tinggi yaitu 31 orang (51,7%). Kualitas hidup secara keseluruhan dengan nilai median 72,5 diperoleh hasil yang sama yaitu 50% lansia dengan kualitas hidup baik dan 50% lansia dengan kualitas hidup buruk. Peran kader relawan dalam peningkatan kualitas hidup lansia dimulai dengan mengidentifikasi kebutuhan perawatan lansia, melakukan perawatan paliatif di rumah lansia di bawah pengawasan petugas kesehatan (dokter puskesmas), menindaklanjuti kebutuhan perawatan dan kesejahteraan lansia, memberikan pendidikan kepada lansia, koordinasi dan administrasi.
Como usar as histórias em quadrinhos na sala de aula
Authors: Oliveira Caio Augusto Guimarães de
Published: July 2022

Resenha da obra Como Usar as Histórias em Quadrinhos na Sala de Aula.
Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score
Authors: He Quanwei , Guo Hongxiu , Bi Rentang , Chen Shaoli , Shen Jing , Long Chunnan , Li Man , Xia Yuanpeng , Zhang Lei , Sun Zhou , Chen Xiaolu , Wang Zhaowei , Gong Daokai , Xu Jingwen , Zhu Dondya , Wan Yan , Hu Bo
Published: July 2022

Background

Intracerebral hemorrhage is the most disabling and lethal form of stroke. We aimed to develop a novel clinical score for neurological deterioration during hospitalization after intracerebral hemorrhage.

Methods and Results

We analyzed data from the CHERRY (Chinese Cerebral Hemorrhage: Mechanism and Intervention) study. Two‐thirds of eligible patients were randomly allocated into the training cohort (n=1027) and one‐third into the validation cohort (n=515). Multivariable logistic regression was used to identify factors associated with neurological deterioration (an increase in National Institutes of Health Stroke Scale of ≥4 or death) within 15 days after symptom onset. A prediction score was developed based on regression coefficients derived from the logistic model. The site, size, gender, National Institutes of Health Stroke Scale, age, leukocyte, sugar (SIGNALS) score was developed as a sum of individual points (0–8) based on site (1 point for infratentorial location), size (3 points for >20 mL of supratentorial hematoma volume or 2 points for >10 mL of infratentorial hematoma volume), sex (1 point for male sex), National Institutes of Health Stroke Scale score (1 point for >10), age (1 point for ≥70 years), white blood cell (1 point for>9.0×10
9
/L), and fasting blood glucose (1 point>7.0 mmol/L). The proportion of patients who suffered from neurological deterioration increased with higher SIGNALS score, showing good discrimination and good calibration in the training cohort (C statistic, 0.821; Hosmer‐Lemeshow test,
P
=0.687) and in the validation cohort (C statistic, 0.848; Hosmer‐Lemeshow test,
P
=0.592), respectively.

Conclusions

The SIGNALS score reliably predicts the risk of in‐hospital neurological deterioration of patients with intracerebral hemorrhage.
Polygenic Risk, Midlife Life's Simple 7, and Lifetime Risk of Stroke
Authors: Thomas Emy A. , Enduru Nitesh , Tin Adrienne , Boerwinkle Eric , Griswold Michael E. , Mosley Thomas H. , Gottesman Rebecca F. , Fornage Myriam
Published: July 2022

Background

Recent genetic discoveries in stroke have unleashed the potential of using genetic information for risk prediction and health interventions aimed at disease prevention. We sought to estimate the lifetime risk of stroke (LTRS) by levels of genetic risk and to investigate whether optimal cardiovascular health can offset the negative impact of high genetic risk on lifetime risk of stroke.

Methods and Results

Study participants were 11 568 middle‐aged adults (56% women, 23% Black adults), who were free of stroke at baseline and were followed up for a median of 28 years. The remaining LTRS was estimated according to levels of genetic risk based on a validated stroke polygenic risk score, and to levels of cardiovascular health based on the American Heart Association Life's Simple 7 recommendations. At age 45, individuals with high, intermediate, and low polygenic risk score had a remaining LTRS of 23.2% (95% CI, 20.8%–25.5%), 13.8% (95% CI, 11.7%–15.8%), and 9.6% (95% CI, 7.3%–11.8%), respectively. Those with both a high genetic risk and an inadequate Life's Simple 7 experienced the highest LTRS: 24.8% (95% CI, 22.0%–27.6%). Across all polygenic risk score categories, those with an optimal Life's Simple 7 had a ≈30% to 43% lower LTRS than those with an inadequate Life's Simple 7. This corresponded to almost 6 additional years lived free of stroke.

Conclusions

The LTRS varies by levels of polygenic risk and cardiovascular health. Maintaining an optimal cardiovascular health can partially offset a high genetic risk, emphasizing the importance of modifiable risk factors and illustrating the potential of personalizing genetic risk information to motivate lifestyle changes for stroke prevention.
Women Who Know Ritual
Authors: Wang Hwa Yeong
Published: July 2022

Too often Confucian women’s voices and experiences are neglected as insignificant. This paper provides a wide and diverse set of examples of traditional Chinese and Korean women who knew and practiced Confucian ritual. Though representing only a small percentage of traditional women, these examples provide clear evidence and compelling arguments that support the following three conclusions. First, that the Confucian tradition did not deny women’s ability to know and perform rituals; second, that Confucian women read, learned, evaluated, decided, and contributed to re/create the conception and practice of ritual; and third, that this led at least some women and the men around them to recognize and admire not only their moral agency but also their ability to become sages.
Beyond Confucianism: Feminist Scholarship on Daoism and Buddhism
Authors: Dai Yuanfang
Published: July 2022

In this paper, I present and assess feminist philosophical thinking related to Daoism and Buddhism. I argue that despite the complexity, feminist scholarship on Daoism and Buddhism illustrates the diversity of feminist scholarship regarding Chinese traditions because it goes beyond the dominant Confucianism. I also argue that it exhibits a transcultural trend in which issues about gender intersect with Daoism and Buddhism. In addition, I suggest that Chinese philosophy should interact with Chinese feminism and gender studies in China to cultivate an explicit Chinese feminist philosophy.
Irigaray and Confucius: A Collaborative Approach to (Feminist) Agency
Authors: Amarantidou Dimitra , D’Ambrosio Paul J.
Published: July 2022

In this paper we take Luce Irigaray’s idea of fluid feminine subjectivity as productive for the project of rethinking agency in a collaborative feminist-Confucian context. We discuss how diffused agency in the Analects can be used alongside Irigaray’s work to critique contemporary notions of atomic agency. Our argument employs the notions of fluidity and agency in Irigaray and the Analects with concentrations on: 1) similarities between Irigaray’s “philosophy of breath” and Confucian ritual; 2) parallels between fluid feminine subjectivity and diffused agency; and 3) a shared concern for the ethical life. We thus see how Confucianism can contribute to contemporary feminist discourse.
詮釋與本體—論本體詮釋學
Authors: Pan (潘德榮) Derong
Published: July 2022

摘 要

成中英從中西比較哲學的視角創造性地提出了本體詮釋學理論, 反思海德格爾與伽達默爾的本體論詮釋學, 揭示出其存在論中的價值缺失；並通過援引中國易學傳統中的道與本體發生, 以自本體與對本體的 “本體詮釋圓環” 使得認識論進路與本體論詮釋進路相結合, 實現了把價值維度和方法論融入了本體詮釋, 以推動當代詮釋學發展。本體詮釋學的創立, 開啟了 “本” 與 “體” 之間循環的本體綜合, 通過本體規範方法與通過方法條理化本體, 使得理解、 價值和方法構成一個有機的圓融整體, 指向了一種德福一致的本體展開, 即德 行詮釋學的發展可能。
The Phantom Senex
Authors: Cowan Robert
Published: July 2022

The character designated by the manuscripts as Senex, who accompanies Andromache and Astyanax in act three of Seneca’s Troades, is problematic in many ways. He is not identified or acknowledged by any other character; his entrance and exit are unannounced; his presence onstage in the first half of the act requires that Astyanax’s two words of dialogue be delivered by a fourth actor or through ventriloquism; his very existence conflicts with the obvious interpretation of at least two sections of Andromache’s dialogue. All of these anomalies can be removed if there is in fact no Senex and the dialogue attributed to him by the manuscripts is spoken by the Chorus leader. This level of involvement in the action by the Chorus would itself be unusual in Senecan tragedy, but it does have parallels and would also fit with the exceptional treatment of the Chorus throughout Troades.
Beyond Violence: Understanding Social Cohesion and Peace Attributes on the Tanzania-Mozambique Border
Authors: Walwa William John
Published: July 2022

The analysis of cross-border issues on the Tanzania-Mozambique border is increasingly influenced and reduced to the current war in northern Mozambique. In effect, positive images, such as social cohesion that historically tied together the communities from the two countries, and which could be tapped to find solutions, received little attention. As such, this paper analyzed the social cohesion attributes of communities on the Tanzania-Mozambique border. It uncovered that cross-border farming, fishing and religious activities have been key sources of social cohesion – helping to reinforce community resilience, livelihoods and peace. However, recent attacks from an extremist group based in Mozambique have undermined these social cohesion attributes and increased risks and vulnerabilities of communities to conflicts and violence. Among other things, achieving sustainable solutions to the ongoing war will demand investing in the protection and promotion of already existing social cohesion attributes that contribute to address socio-economic challenges of border communities.
How can shared reading be used to develop community connectivity in the contemporary church?
Authors: Baverstock Alison , Steinitz Jackie , Cowie Andrew
Published: July 2022

This paper reports on a project to use, within church communities, previous experience in universities and schools of shared reading for the purposes of outreach, widening participation, and community inclusion. It outlines and explores the experience of selecting a book, and its subsequent discussion among a group of parishioners, to promote a sense of connectedness and belonging. The outcomes have implications for creating and strengthening links within existing church communities, reaching out to those who live locally but are not regular church attenders, and drawing others towards the church from the wider, not necessarily geographically local, community.
Discovery through iNaturalist: new species and new records of oak gall wasps (Hymenoptera: Cynipidae: Cynipini) from Texas, USA
Authors: ZHANG Y. MILES , SASAN KIMBERLIE , O’KENNON ROBERT J. , KRANZ ADAM J.
Published: July 2022

A new species of the genus Druon Kinsey, 1937, D. laceyi Zhang, Sasan & O’Kennon sp. nov. is described on host plant Quercus laceyi Small from central Texas. We also re-establish Andricus lustrans Beutenmüller, 1913 comb.rev., and transfer Striatoandricus aciculatus (Beutenmüller, 1909) comb. nov. from Andricus. Finally, we report a new state and host record for Druon gregori Melika, Nicholls & Stone, 2022. All observations were first shared on the social platform iNaturalist, highlighting the potential of cybertaxonomy in uncovering overlooked biodiversity.
The Application of Sensitive Nano-Confined Nanoparticle System Using siRNA Targeting Extracellular Signal-Regulated Kinase (ERK)/Mitogen-Activated Protein Kinase (MAPK) Pathway in Gastrointestinal Cancer
Authors: Wu Runda , Tong Shan , Kahrizi Mohammad Saeed , Zhu Zheng , Chen Xin
Published: July 2022

In this study we tried to develop a Sensitive Nano-Confined Nanoparticles (S-NCN) system using siRNA against Programmed death-ligand 1 (PDL-1) and Polo Like Kinase 1 (Plk1) to treat gastrointestinal cancer. In this regard, we first synthesized the corresponding materials, prepared the
S-NCN system, and verified its functionality. Subsequently, we demonstrated in vitro that S-NCN delivery of siPlk1 could effectively downregulate the expression of Plk1 gene in GC1436 cells and lead to significant apoptosis of tumor cells. Xenografted gastrointestinal cancer model mice
were used to evaluate the in vivo efficacy of the nanoparticle. We have demonstrated that the developed S-NCN system can efficiently bind siRNA and deliver it into target tumor cells, solving the main obstacle of siRNA delivery in vivo and effectively silencing target genes with
a very potential delivery option.
Enhanced Glioblastoma Selectivity of Harmine via the Albumin Carrier
Authors: Liu Shi-Hui , Wang Qing-Zhen , Liu Tao , Bai Ru , Ma Man-Man , Liu Qiao-Lin , Zhou Hui-Ge , Liu Jing , Wang Mei
Published: July 2022

Glioblastoma, the most common tumor in the brain, has witnessed very little clinical progress over the last decades. Exploring and discovering new therapeutic strategies for glioblastoma has become a critical problem. Harmine (HM), belonging to the beta-carboline alkaloid, is a natural
product and isolated from the seeds of Peganum harmala L., which own notable antitumor activity in vitro. However, the poor water solubility and less selectivity of HM severely limit its clinical use. For enhancing its selective ability to tumor cells, we fabricated a kind of
protein nanoparticles (BSA-HM NPs), composed of the modified bovine serum albumin (BSA) and HM. It was substantiated through in vitro and in vivo experiment that BSA-HM NPs could predominantly accumulate in tumor tissues and exhibited remarkably enhanced antitumor efficacy. This
study provides a promising strategy to improve the bioavailability and avoid side effects of HM as antitumor agents by choosing BSA as carriers.
Two New 3D Supramolecular Complexes: Photocatalytic Properties and Treatment Activity for Gastric Cancer
Authors: Lu Jiangkun , Yu Wei , Ji Guoguo , Wu Ming , Geng Jinhong , Qi Jinhui , Gong Jianming
Published: July 2022

Two new coordination polymers, [Cu2(5-MeO-Hip)4(py)4]n (1) and [Co(5-EtO-ip)(4,4′-bipy)]n·n(MeOH) (2) (5-MeO-H2ip is 5-methoxyisophthalic acid, 5-EtO-H2ip is 5-ethoxyisophthalic acid,
py is pyridine, and 4,4′-bipy is 4,4′-bipyridine), were created via solvothermal self-assembly. The thermal steadiness and photocatalytic functions of 1 and 2 were detected, and their application values in gastric cancer and the related mechanism were discussed. CCK-8
assay was used to determine the inhibitory activity toward gastric cancer cells’ viability, and real-time RT-PCR was employed to examine the gastric cancer cells’ Notch signaling pathway activity.
Targeting the Conserved Sequence of the Substrate for the Proteinase of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2) Using Nano-Networks: Efficacy, Stability, and No Cytotoxicity
Authors: Nahhas Alaa F. , Webster Thomas J.
Published: July 2022

Herein, we designed a nano peptide that contains three important motifs for targeting the chemotrypsin-like cysteine protease (3CLpro) which is the enzyme responsible for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication. The novel nano peptide contains
the Nap Phe-Phe motif that is responsible for peptide self-assembly, an octapeptide (Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe) motif where the enzyme recognizes the substrate and induces enzyme sensitivity, and a tetrapeptide motif which is positively charged containing the peptide (Lys)4
that facilitates penetration into a cell. The nano peptide was characterized using Proton Nuclear Magnetic Resonance (H-NMR) and Liquid Chromatography-Mass Spectrometry (LC-MS) to confirm its structure. In vitro results showed that the presently formulated nano peptide was not cytotoxic
to fibroblasts for up to 72 hours, bound to 3CLpro, inhibited SARS-CoV-2 Omicron variant virus replication, and was stable for binding for up to one week in culture. In this manner, this timely study demonstrates that this novel nano peptide should be studied for a wide range of
Coronavirus Disease (COVID-19) prophylactic or therapeutic applications.