bluuebunny/crossref_metadata_2025 huggingface dataset:
Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
Authors: Woodard Vanessa , Thoene Melissa , Van Ormer Matthew , Thompson Maranda , Hanson Corrine , Natarajan Sathish , Mukherjee Maheswari , Yuil-Valdes Ana , Nordgren Tara , Ulu Arzu , Harris Jackson Kristina , Anderson-Berry Ann
Published: March 2021

Polyunsaturated fatty acids (PUFAs) are essential for fetal development, and intrauterine transfer is the only supply of PUFAs to the fetus. The prevailing theory of gestational nutrient transfer is that certain nutrients (including PUFAs) may have prioritized transport across the placenta. Numerous studies have identified correlations between maternal and infant fatty acid concentrations; however, little is known about what role maternal PUFA status may play in differential intrauterine nutrient transfer. Twenty mother–infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood, and placental tissue samples. Plasma concentrations of PUFAs were assessed using gas chromatography (GC-FID). Intrauterine transfer percentages for each fatty acid were calculated as follows: ((cord blood fatty acid level/maternal blood fatty acid level) × 100). Kruskal–Wallis tests were used to compare transfer percentages between maternal fatty acid tertile groups. A p-value < 0.05 was considered significant. There were statistically significant differences in intrauterine transfer percentages of arachidonic acid (AA) (64% vs. 65% vs. 45%, p = 0.02), eicosapentaenoic acid (EPA) (41% vs. 19% vs. 17%, p = 0.03), and total fatty acids (TFA) (27% vs. 26% vs. 20%, p = 0.05) between maternal plasma fatty acid tertiles. Intrauterine transfer percentages of AA, EPA, and TFA were highest in the lowest tertile of respective maternal fatty acid concentration. These findings may indicate that fatty acid transfer to the fetus is prioritized during gestation even during periods of maternal nutritional inadequacy.
An Epidemiological Survey Regarding Ticks and Tick-Borne Diseases among Livestock Owners in Punjab, Pakistan: A One Health Context
Authors: Hussain Sabir , Hussain Abrar , Ho Jeffery , Li Jun , George David , Rehman Abdul , Zeb Jehan , Sparagano Olivier
Published: March 2021

Recent global changes have led to an increase in the spread of ticks and tick-borne diseases (TBDs) affecting domestic ruminants and humans, with an annual loss of US $13.9–$18.7 billion. The current study determined the perception and practices of livestock farmers regarding tick infestation. A total of 112 livestock farms were surveyed in Punjab, Pakistan, among which animals from 42 (37.5%) farms were infested with ticks. Only 28.6% (n = 32) of the dairy farmers were consulting veterinarians for ticks control, while 86.7% (n = 97) of the respondents did not consider biosecurity measures in the control of tick transmission. Most of the respondents, 71.4% (n = 80), did not consider manual tick removal from their animals (i.e., by hand, followed by physically crushing) as a risky practice for spreading zoonotic diseases. Improper disposal of bottles of acaricides in the farm drainage was also observed, putting the environment and aquatic life at risk. These wrong practices may contribute to high disease burdens and economic losses, increasing the possibility of transmission of zoonotic TBDs and pollution of the environment. Therefore, an integrated One Health approach is required for the control of TBDs through environmentally friendly approaches.
High-Throughput Microfluidic Real-Time PCR for the Detection of Multiple Microorganisms in Ixodid Cattle Ticks in Northeast Algeria
Authors: Boularias Ghania , Azzag Naouelle , Galon Clemence , Šimo Ladislav , Boulouis Henri-Jean , Moutailler Sara
Published: March 2021

Ixodid ticks are hematophagous arthropods considered to be prominent ectoparasite vectors that have a negative impact on cattle, either through direct injury or via the transmission of several pathogens. In this study, we investigated the molecular infection rates of numerous tick-borne pathogens in ticks sampled on cattle from the Kabylia region, northeastern Algeria, using a high-throughput microfluidic real-time PCR system. A total of 235 ticks belonging to seven species of the genera Rhipicephalus, Hyalomma, and Ixodes were sampled on cattle and then screened for the presence of 36 different species of bacteria and protozoans. The most prevalent tick-borne microorganisms were Rickettsia spp. at 79.1%, followed by Francisella-like endosymbionts (62.9%), Theileria spp. (17.8%), Anaplasma spp. (14.4%), Bartonella spp. (6.8%), Borrelia spp. (6.8%), and Babesia spp. (2.5%). Among the 80.4% of ticks bearing microorganisms, 20%, 36.6%, 21.7%, and 2.1% were positive for one, two, three, and four different microorganisms, respectively. Rickettsia aeschlimannii was detected in Hyalomma marginatum, Hyalomma detritum, and Rhipicephalus bursa ticks. Rickettsia massiliae was found in Rhipicephalus sanguineus, and Rickettsiamonacensis and Rickettsia helvetica were detected in Ixodesricinus. Anaplasma marginale was found in all identified tick genera, but Anaplasma centrale was detected exclusively in Rhipicephalus spp. ticks. The DNA of Borrelia spp. and Bartonella spp. was identified in several tick species. Theileria orientalis was found in R. bursa, R. sanguineus, H. detritum, H. marginatum, and I. ricinus and Babesia bigemina was found in Rhipicephalus annulatus and R. sanguineus. Our study highlights the importance of tick-borne pathogens in cattle in Algeria.
Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine
Authors: Moatasim Yassmin , Kandeil Ahmed , Mostafa Ahmed , Kutkat Omnia , Sayes Mohamed El , El Taweel Ahmed N. , AlKhazindar Maha , AbdElSalam Elsayed T. , El-Shesheny Rabeh , Kayali Ghazi , Ali Mohamed A.
Published: March 2021

Since its emergence in 2014, the highly pathogenic avian influenza H5N8 virus has continuously and rapidly spread worldwide in the poultry sector resulting in huge economic losses. A typical inactivated H5N8 vaccine is prepared using the six internal genes from A/PR8/1934 (H1N1) and the two major antigenic proteins (HA and NA) from the circulating H5N8 strain with the HA modified to a low pathogenic form (PR8HA/NA-H5N8). The contribution of the other internal proteins from H5N8, either individually or in combination, to the overall protective efficacy of PR8-based H5N8 vaccine has not been investigated. Using reverse genetics, a set of PR8-based vaccines expressing the individual proteins from an H5N8 strain were rescued and compared to the parent PR8 and low pathogenic H5N8 strains and the commonly used PR8HA/NA-H5N8. Except for the PR8-based vaccine strains expressing the HA of H5N8, none of the rescued combinations could efficiently elicit virus-neutralizing antibodies. Compared to PR8, the non-HA viral proteins provided some protection to infected chickens six days post infection. We assume that this late protection was related to cell-based immunity rather than antibody-mediated immunity. This may explain the slight advantage of using full low pathogenic H5N8 instead of PR8HA/NA-H5N8 to improve protection by both the innate and the humoral arms of the immune system.
Anti-Inflammatory Effects of a Polyphenol, Catechin-7,4′-O-Digallate, from Woodfordia uniflora by Regulating NF-κB Signaling Pathway in Mouse Macrophages
Authors: Kim Eui Jin , Seo Ji Bin , Yu Jae Sik , Lee Seoyoung , Lim Jae Sung , Choi Jeong Uk , Lee Chang-Min , Rashan Luay , Kim Ki Hyun , Cho Young-Chang
Published: March 2021

Inflammation is a defense mechanism that protects the body from infections. However, chronic inflammation causes damage to body tissues. Thus, controlling inflammation and investigating anti-inflammatory mechanisms are keys to preventing and treating inflammatory diseases, such as sepsis and rheumatoid arthritis. In continuation with our work related to the discovery of bioactive natural products, a polyphenol, catechin-7,4′-O-digallate (CDG), was isolated from Woodfordia uniflora, which has been used as a sedative and remedy for skin infections in the Dhofar region of Oman. Thus far, no study has reported the anti-inflammatory compounds derived from W. uniflora and the mechanisms underlying their action. To investigate the effects of CDG on the regulation of inflammation, we measured the reduction in nitric oxide (NO) production following CDG treatment in immortalized mouse Kupffer cells (ImKCs). CDG treatment inhibited NO production through the downregulation of inducible nitric oxide synthase expression in lipopolysaccharide (LPS)-stimulated ImKCs. The anti-inflammatory effects of CDG were mediated via the inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation, an important inflammatory-response-associated signaling pathway. Moreover, CDG treatment has regulated the expression of pro-inflammatory cytokines, such as IL-6 and IL-1β. These results suggested the anti-inflammatory action of CDG in LPS-stimulated ImKCs.
The Objective Bayesian Probability that an Unknown Positive Real Variable Is Greater Than a Known Is 1/2
Authors: Fiorillo Christopher D. , Kim Sunil L.
Published: March 2021

If there are two dependent positive real variables x1 and x2, and only x1 is known, what is the probability that x2 is larger versus smaller than x1? There is no uniquely correct answer according to “frequentist” and “subjective Bayesian” definitions of probability. Here we derive the answer given the “objective Bayesian” definition developed by Jeffreys, Cox, and Jaynes. We declare the standard distance metric in one dimension, d(A,B)≡|A−B|, and the uniform prior distribution, as axioms. If neither variable is known, P(x2x1). This appears obvious, since the state spaces x2x1 have equal size. However, if x1 is known and x2 unknown, there are infinitely more numbers in the space x2>x1 than x2<x1. Despite this asymmetry, we prove P(x2x1∣x1), so that x1 is the median of p(x2|x1), and x1 is statistically independent of ratio x2/x1. We present three proofs that apply to all members of a set of distributions. Each member is distinguished by the form of dependence between variables implicit within a statistical model (gamma, Gaussian, etc.), but all exhibit two symmetries in the joint distribution p(x1,x2) that are required in the absence of prior information: exchangeability of variables, and non-informative priors over the marginal distributions p(x1) and p(x2). We relate our conclusion to physical models of prediction and intelligence, where the known ’sample’ could be the present internal energy within a sensor, and the unknown the energy in its external sensory cause or future motor effect.
Mitochondrial mRNA Processing in the Chlorophyte Alga Pediastrum duplex and Streptophyte Alga Chara vulgaris Reveals an Evolutionary Branch in Mitochondrial mRNA Processing
Authors: Proulex Grayson C. R. , Meade Marcus J. , Manoylov Kalina M. , Cahoon A. Bruce
Published: March 2021

Mitochondria carry the remnant of an ancestral bacterial chromosome and express those genes with a system separate and distinct from the nucleus. Mitochondrial genes are transcribed as poly-cistronic primary transcripts which are post-transcriptionally processed to create individual translationally competent mRNAs. Algae post-transcriptional processing has only been explored in Chlamydomonas reinhardtii (Class: Chlorophyceae) and the mature mRNAs are different than higher plants, having no 5′ UnTranslated Regions (UTRs), much shorter and more variable 3′ UTRs and polycytidylated mature mRNAs. In this study, we analyzed transcript termini using circular RT-PCR and PacBio Iso-Seq to survey the 3′ and 5′ UTRs and termini for two green algae, Pediastrum duplex (Class: Chlorophyceae) and Chara vulgaris (Class: Charophyceae). This enabled the comparison of processing in the chlorophyte and charophyte clades of green algae to determine if the differences in mitochondrial mRNA processing pre-date the invasion of land by embryophytes. We report that the 5′ mRNA termini and non-template 3′ termini additions in P. duplex resemble those of C. reinhardtii, suggesting a conservation of mRNA processing among the chlorophyceae. We also report that C. vulgaris mRNA UTRs are much longer than chlorophytic examples, lack polycytidylation, and are polyadenylated similar to embryophytes. This demonstrates that some mitochondrial mRNA processing events diverged with the split between chlorophytic and streptophytic algae.
Eggplant Peels as a Valuable Source of Anthocyanins: Extraction, Thermal Stability and Biological Activities
Authors: Condurache (Lazăr) Nina-Nicoleta , Croitoru Constantin , Enachi Elena , Bahrim Gabriela-Elena , Stănciuc Nicoleta , Râpeanu Gabriela
Published: March 2021

This study aimed to use eggplant peels as a potential source of anthocyanins with biological activities. Two different extraction methods were tested in order to obtain extracts with a high anthocyanin content. The selected methods were the solid–liquid extraction (SLE) and ultrasound-assisted extraction (UAE) methods. For each method, two concentrations of ethanol (EtOH) were used, while varying the extraction time and temperature. Based on the results, the extracts obtained by SLE using EtOH 96% after 30 min of extraction at 50 °C showed the highest anthocyanin concentration. The UAE allowed the best results with EtOH 96% after 30 min at 25 °C. Both selected extracts showed similar chromatographic profiles, with delphinidin 3-O-rutinoside as the major anthocyanin, but in a higher concentration in UAE. The extracts also presented inhibitory activity against lipoxygenase (LOX), lipase, and α-amylase, thus suggesting a possible involvement in reducing the risk of various disorders. The first order kinetic model was used to predict the changes that can occur in the anthocyanin content and antioxidant activity from the eggplant peel extract. The calculated kinetic and thermodynamic parameters confirm the irreversible degradation of phytochemicals.
Indirect Monitoring of Anaerobic Digestion for Cheese Whey Treatment
Authors: Flores-Mejia Hilario , Lara-Musule Antonio , Hernández-Martínez Eliseo , Aguilar-López Ricardo , Puebla Hector
Published: March 2021

Efficient monitoring is an open problem in the operation of anaerobic digestion processes, due to the lack of accurate, low-cost, and proper sensors for the on-line monitoring of key process variables. This paper presents two approaches for the indirect monitoring of the anaerobic digestion of cheese whey wastewater. First, the observability property is addressed using conventional and nonconventional techniques, including an observability index. Then, two model-based observer techniques, an extended Luenberger observer, a sliding mode observer, and a data-driven technique based on fractal analysis are formulated and discussed. The performance and capabilities of the proposed methodologies are illustrated on a validated model with experimental data of the anaerobic digestion of cheese whey. Experimental pH measurements are used for the data-driven approach based on fractal analysis. The experimental data sets correspond to experimental conditions (pH > 7.5 and temperature (T) = 40 °C) favoring volatile fatty acid (VFA) production (30 g/L) with simultaneously acceptable biogas production (3420 mL). Results also show that the proposed observers were able to predict satisfactory key process variables. On the other hand, the fractal analysis provides reliable qualitative trends of VFA production and chemical oxygen demand (COD) consumption.
Special Issue “Design, Control and Optimization of Desalination Processes”
Authors: Onishi Viviani C. , Mujtaba Iqbal M.
Published: March 2021

Water scarcity due to the ever-increasing worldwide demand and climate change is one of the greatest hurdles of our time [...]
Observation Quality Assessment and Performance of GNSS Standalone Positioning with Code Pseudoranges of Dual-Frequency Android Smartphones
Authors: Robustelli Umberto , Paziewski Jacek , Pugliano Giovanni
Published: March 2021

The new generation of Android smartphones is equipped with GNSS chips capable of tracking multi-frequency and multi-constellation data. In this work, we evaluate the positioning performance and analyze the quality of observations collected by three recent smartphones, namely Xiaomi Mi 8, Xiaomi Mi 9, and Huawei P30 pro that take advantage of such chips. The analysis of the GNSS observation quality implies that the commonly employed elevation-dependent function is not optimal for smartphone GNSS observation weighting and suggests an application of the C/N0-dependent one. Regarding smartphone code signals on L5 and E5a frequency bands, we found that they are characterized with noticeably lower noise as compared to E1 and L1 ones. The single point positioning results confirm an improvement in the performance when the weights are a function of the C/N0-rather than those dependent on the satellite elevation and that a smartphone positioning with E5a code observations significantly outperforms that with E1 signals. The latter is expressed by a drop of the horizontal RMS from 8.44 m to 3.17 m for Galileo E1 and E5a solutions of Xiaomi Mi 9 P30, respectively. The best positioning accuracy of multi-GNSS single-frequency (L1/E1/B1/G1) solution was obtained by Huawei P30 with a horizontal RMS of 3.24 m. Xiaomi Mi 8 and Xiaomi Mi 9 show a horizontal RMS error of 4.14 m and 4.90 m, respectively.
Evaluation of the Metrological Performance of a Handheld 3D Laser Scanner Using a Pseudo-3D Ball-Lattice Artifact
Authors: Bonin Rémi , Khameneifar Farbod , Mayer J.R.R.
Published: March 2021

This paper proposes the use of a pseudo-3D ball-lattice artifact to characterize a handheld laser scanner from a metrological standpoint. The artifact allows the computation of local and global errors in measurement by using the reference-frame-independent parameters of size, form, and distance within the measuring volume of the scanner, and in a single point cloud, without the need for registration. A set of tests was performed using the whole measuring volume, and three acquisition parameters, namely the orientation of the sweeps during the scans, the exposure time, and the distance to the scanner were analyzed for their effects on the accuracy of the scan data. A composite error including the errors in measuring size, form, and distance was used as a single figure of merit to characterize the performance of the scanner in relation to the data-acquisition parameters. The orientation of sweeps did not have a considerable effect on the errors. The accuracy of the scan data was strongly affected by exposure time and its interaction with the distance at which the artifact was scanned. The errors followed a quadratic trend with respect to the distance of the artifact to the scanner. The tested scanner performed best at its manufacturer’s recommended stand-off distance.
Human Body Parts Proximity Measurement Using Distributed Tactile Robotic Skin
Authors: Klimaszewski Jan , Władziński Michał
Published: March 2021

Safety in human–machine cooperation is the current challenge in robotics. Safe human–robot interaction requires the development of sensors that detect human presence in the robot’s workspace. Detection of this presence should occur before the physical collision of the robot with the human. Human to robot proximity detection should be very fast, allowing machine elements deceleration to velocities safe for human–machine collision. The paper presents a new, low-cost design of distributed robotic skin, which allows real-time measurements of the human body parts proximity. The main advantages of the proposed solution are low cost of its implementation based on comb electrodes matrix and real-time operation due to fast and simple electronic design. The main contribution is the new idea of measuring the distance to human body parts by measuring the operating frequency of a rectangular signal generator, which depends on the capacity of the open capacitor. This capacitor is formed between the comb electrodes matrix and a reference plate located next to the matrix. The capacitance of the open capacitor changes if a human body part is in vicinity. The application of the developed device can be very wide. For example, in the field of cooperative robots, it can lead to the improvement of human–machine interfaces and increased safety of human–machine cooperation. The proposed construction can help to meet the increasing requirements for cooperative robots.
Neural Network for Enhancing Microscopic Resolution Based on Images from Scanning Electron Microscope
Authors: Tsai Chia-Hung Dylan , Yeh Chia-Hao
Published: March 2021

In this paper, an artificial neural network is applied for enhancing the resolution of images from an optical microscope based on a network trained with the images acquired from a scanning electron microscope. The resolution of microscopic images is important in various fields, especially for microfluidics because the measurements, such as the dimension of channels and cells, largely rely on visual information. The proposed method is experimentally validated with microfluidic structure. The images of structural edges from the optical microscope are blurred due to optical effects while the images from the scanning electron microscope are sharp and clear. Intensity profiles perpendicular to the edges and the corresponding edge positions determined by the scanning electron microscope images are plugged in a neural network as the input features and the output target, respectively. According to the results, the blurry edges of the microstructure in optical images can be successfully enhanced. The average error between the predicted channel position and ground truth is around 328 nanometers. The effects of the feature length are discussed. The proposed method is expected to significantly contribute to microfluidic applications, such as on-chip cell evaluation.
BLAINDER—A Blender AI Add-On for Generation of Semantically Labeled Depth-Sensing Data
Authors: Reitmann Stefan , Neumann Lorenzo , Jung Bernhard
Published: March 2021

Common Machine-Learning (ML) approaches for scene classification require a large amount of training data. However, for classification of depth sensor data, in contrast to image data, relatively few databases are publicly available and manual generation of semantically labeled 3D point clouds is an even more time-consuming task. To simplify the training data generation process for a wide range of domains, we have developed the BLAINDER add-on package for the open-source 3D modeling software Blender, which enables a largely automated generation of semantically annotated point-cloud data in virtual 3D environments. In this paper, we focus on classical depth-sensing techniques Light Detection and Ranging (LiDAR) and Sound Navigation and Ranging (Sonar). Within the BLAINDER add-on, different depth sensors can be loaded from presets, customized sensors can be implemented and different environmental conditions (e.g., influence of rain, dust) can be simulated. The semantically labeled data can be exported to various 2D and 3D formats and are thus optimized for different ML applications and visualizations. In addition, semantically labeled images can be exported using the rendering functionalities of Blender.
A Survey-Based Education Needs Analysis of Employment Support Programs for Hospitality Undergraduate Students
Authors: Na Tae-Kyun , Lee Sun-Ho
Published: March 2021

The purpose of this study was to analyze employment support programs that should be prioritized for hospitality undergraduate students in Korea, given the lack of such programs that are tailored to students’ majors. Using a questionnaire survey, we measured the differences between the perceived importance and the perceived current level of availability of employment support programs recognized by 384 students enrolled in hospitality-related courses. Both 2-year and 4-year majors recognized employment information support, certificate programs, career seminars, overseas training support, field practice programs, and overseas employment support as high-priority programs. Individual career counseling, mentoring, and industry–academic cooperation courses were the highest priority programs that should be applied to 2-year majors, but in the case of 4-year majors, these three programs were found to be relatively well supported by universities. Mock interviews, language programs, and employment-related courses were the top priority programs to support 4-year majors. However, 2-year majors perceived that mock interviews and language programs were of low importance, and there was little difference between the importance and current level of employment-related courses. It is necessary to develop support programs from the learner’s point of view by accurately grasping the needs for employment support programs.
Biodiesel Production from Reutealis trisperma Oil Using Conventional and Ultrasonication through Esterification and Transesterification
Authors: Riayatsyah Teuku Meurah Indra , Thaib Razali , Silitonga Arridina Susan , Milano Jassinnee , Shamsuddin Abd. Halim , Sebayang Abdi Hanra , Rahmawaty  , Sutrisno Joko , Mahlia Teuku Meurah Indra
Published: March 2021

The limitation of fossil fuel sources and negative environmental impact persuade scientists around the world to find a solution. One possible solution is by using renewable fuel to replace fossil fuel with an inexpensive, fast, and effective production process. The objective of this study is to investigate the biodiesel production from crude Reutealis trisperma oil using the conventional and the ultrasonic bath stirrer method through the esterification and transesterification process. The result shows that the most effective reaction time with an optimum condition for the esterification and transesterification of Reutealis trisperma oil is at 2 h 30 min by using the ultrasonic bath stirrer method. The optimum conditions at a temperature of 55 °C for the esterification and at 60 °C for transesterification with 2% (v/v) of sulphuric acid with catalyst concentration of 0.5 wt.% were a methanol-to-oil ratio of 60%, and agitation speed of 1000 rpm. This optimum condition gives the highest yield of 95.29% for the Reutealis trisperma biodiesel. The results showed that the ultrasonic bath stirrer method had more effect on the reaction time needed than using the conventional method and reduced half of the conventional method reaction time. Finally, the properties of Reutealis trisperma biodiesel fulfilled the ASTM D6751 and EN 14214 biodiesel standards with density, 892 kg/m3; pour point, −2 °C; cloud point, −1 °C; flash point, 206.5 °C; calorific value, 40.098 MJ/kg; and acid value, 0.26 mg KOH/g.
A Measure of Tourist Responsibility
Authors: Dias Álvaro , Aldana Inês , Pereira Leandro , da Costa Renato Lopes , António Nelson
Published: March 2021

In a post-pandemic context, destinations are questioning mass tourism, and are focusing on more sustainable segments, looking for more responsible tourists. This requires obtaining relevant information to assess what kind of tourists visit the destination and, at the same time, to monitor changes in tourists’ behavior and attitudes. This study aims to respond to this challenge by creating a measure to assess the tourist’s responsibility. Using a scale development method, a sequential mixed-method approach is conducted to identify scale dimensions and items. An initial qualitative approach is implemented for item generation using focus group and face-to-face interviews. Then, a second study based on a survey is conducted for exploratory factor analysis. A third study, also based on a survey is performed to obtain a new sample for confirmatory factor analysis. Findings show two dimensions: civic responsibility and philanthropic responsibility, allowing an understanding of how tourists can act responsibly in destinations without compromising the ecological footprint on the planet. Theoretical and managerial implications are discussed.
Organizational Commitment and Lean Sustainability: Literature Review and Directions for Future Research
Authors: Benkarim Amal , Imbeau Daniel
Published: March 2021

The vast majority of works published on Lean focus on the evaluation of tools and/or the strategies needed for its implementation. Although many authors highlight the degree of employee commitment as one of the key aspects of Lean, what has gone largely unnoticed in the literature, is that few studies have examined in-depth the concept of organizational commitment in connection with Lean. With this narrative literature review article, our main objective is (1) to identify and analyze an extensive body of literature that addresses the Lean Manufacturing approach and how it relates to employee commitment, emphasizing affective commitment as the main type of organizational commitment positively associated with Lean, and (2) to highlight the management practices required to encourage this kind of commitment and promote the success and sustainability of Lean. This paper aims to provide a comprehensive overview that can help researchers and practitioners interested in Lean better understand the importance of employee commitment in this type of approach, and as well, to identify related research questions.
Are Cities Truly Dispersed? A Long-Term Analysis of Vertical Profile of Settlements in Athens’ Metropolitan Region
Authors: Rodrigo-Comino Jesús , Ermini Barbara
Published: March 2021

Using nonparametric, exploratory statistics, the spatial structure of the city’s vertical profile was investigated at the municipal scale in Athens’ metropolitan region (Greece), evaluating changes over a sufficiently long time interval (1983–2019) that encompasses different phases of the urban cycle in Greece. Assuming the vertical profile of cities as an honest indicator of urban form, the study was aimed to test the intensity and spatial direction of the (supposed) change in settlement models toward sprawl. Transitioning slowly from a dense to a more dispersed settlement structure, Athens’ dynamics revealed a quite representative model for cities expanding significantly but remaining substantially compact and dense, while responding similarly to different (external) economic stimuli. Nonparametric correlation between the average (vertical) profile of each municipality and the distance from downtown Athens revealed a substantially stable mono-centric structure over time, with small changes over time still responding to factors dependent on the urban gradient. The inherent shift towards “horizontal” urban expansion was relatively modest and characteristic of few periurban contexts. The empirical results of this study can be envisaged as a practical tool of regional planning, allowing continuous monitoring of urban sprawl and land take in complex systems under rapid socioeconomic changes.
The Effects of Green Transformational Leadership on Adoption of Environmentally Proactive Strategies: The Mediating Role of Green Engagement
Authors: Huang Stanley Y. B. , Ting Chih-Wen , Li Ming-Way
Published: March 2021

To explore key antecedents of environmentally proactive strategies, this work uses upper echelons theory to examine a novel concept-green engagement with its antecedents (green transformational leadership) and consequence (environmentally proactive strategies). This work employed a potential growth curve model with 501 CEOs and top management teams of technology manufacturing businesses in Greater China at three times over eight months to analyze the theoretical model. The results of this work showed that the green transformational leadership of CEOs significantly predicts positive changes of green engagement of top management teams, which consequently predicts environmentally proactive strategies. These findings provide theoretical insights for the field of environmental development that can advance the literature on environmentally proactive strategies.
Would Overconfident CEOs Engage More in Environment, Social, and Governance Investments? With a Focus on Female Representation on Boards
Authors: Lee Jaehong , Kim Eunsoo
Published: March 2021

This study examines the relationship between CEO overconfidence, environment, social, and governance investments, and firm value. Drawing on insights from upper echelon and agency theory, greater female representation on boards is expected to act as an independent monitoring mechanism to control and reconcile CEO overconfidence which leads to enhancement of corporate value induced by environment, social, and governance investments. Empirical evidence in this study finds that, on average, overconfident managers tend to engage in ESG investments in South Korea. Furthermore, in firms with high environment, social, and governance investments, the negative association between CEO overconfidence and firm value is mitigated, showing that environment, social, and governance investments are effective moderators in controlling and constraining managerial overconfidence. Finally, we find that the joint impact of CEO overconfidence and environment, social, and governance investments on corporate value is distinctive in firms with female board representation. Taken together, we find that negative effects associated with CEO overconfidence can be alleviated by the role of female leadership that links corporate environment, social, and governance investments to firm value.
Food Waste and Social Practices in Australian Households
Authors: Keegan Emily , Breadsell Jessica K.
Published: March 2021

Food waste is a critical sustainability issue, and the solutions, particularly in middle- to high-income countries, lie in shifting practices within households. The purpose of this paper is to contribute to the research in an Australian context, provide insights from a social practice theory approach and understand the influence of growing your own food to waste production. The research is based on respondents completing a two-week food diary documenting food acquisition and disposal and then undertaking a survey on their food practices and attitudes to waste. This study finds that the preparation of meals and storage practices are critical towards the production of food waste. These practices can be shifted by focusing on upskilling and the introduction of new materiality or technologies. The acquisition of food is also a pivotal practice in which to intervene in order to reduce waste in other food practices in the household. Interventions, such as growing your own food, are recommended to shift food practices to reduce an output of waste to landfill. The research is limited by its reliance on self-reported data for food waste. However, the focus on social practices in food waste is novel in an Australian context.
Quantitative Dissection of Salt Tolerance for Sustainable Wheat Production in Sodic Agro-Ecosystems through Farmers’ Participatory Approach: An Indian Experience
Authors: Sheoran Parvender , Kumar Arvind , Sharma Raman , Prajapat Kailash , Kumar Ashwani , Barman Arijit , Raju R. , Kumar Satyendra , Dar Yousuf Jaffer , Singh Ranjay K. , Sanwal Satish Kumar , Yadav Rajender Kumar , Chahal Ved Prakash , Sharma Parbodh Chander
Published: March 2021

To explore the comparative effects of field sodicity (soil pH) and irrigation water residual alkalinity (RSCiw) on physiological and biochemical attributes of salt tolerance, and crop performance of two wheat varieties (KRL 210, HD 2967), a total of 308 on-farm trials were carried out in sodicity affected Ghaghar Basin of Haryana, India. Salt tolerant variety KRL 210 maintained relatively higher leaf relative water content (RWC; 1.9%), photosynthetic rate (Pn; 5.1%), stomatal conductance (gS; 6.6%), and transpiration (E; 4.1%) with lower membrane injury (MII; −8.5%), and better control on accumulation of free proline (P; −18.4%), Na+/K+ in shoot (NaK_S; −23.1%) and root (NaK_R; −18.7%) portion compared to traditional HD 2967. Altered physiological response suppressed important yield-related traits revealing repressive effects of sodicity stress on wheat yields; albeit to a lesser extent in KRL 210 with each gradual increase in soil pH (0.77–1.10 t ha−1) and RSCiw (0.29–0.33 t ha−1). HD 2967 significantly outyielded KRL 210 only at soil pH ≤ 8.2 and RSCiw ≤ 2.5 me L−1. By comparisons, substantial improvements in salt tolerance potential of KRL 210 with increasing sodicity stress compensated in attaining significantly higher yields as and when soil pH becomes >8.7 and RSCiw > 4 me L−1. Designing such variety-oriented threshold limits of sodicity tolerance in wheat will help address the challenge to enhance crop resilience, closing the yield gaps and improve rural livelihood under the existing or predicted levels of salt stress.
Effects of Marketing Decisions on Brand Equity and Franchise Performance
Authors: Lee Eunkyung , Kim Ji-Hern , Rhee Chang Seop
Published: March 2021

The purpose of this study is to provide a way of pursuing a balanced profitability between franchisors and franchisees leading to the sustainability in franchising. Based on a belief that the formation of brand-centric relationship is vital for the success of franchising system, we constructed a model that examines the relationships between marketing decisions, brand equity, and the financial performances of franchisors and franchisees. We used actual data of the Korean franchise chains, including measures of channel intensity and advertising and promotional activities as franchise marketing decisions as well as the profitability of franchisors and franchisees for the analysis. The results of analysis show that while advertising and promotion expenditure has a positive impact on the performances of both franchisors and franchisees, the number of stores does not influence them in the same way. This indicates that their interests may conflict. This study suggests that marketing decisions can be utilized as a means of achieving balanced profitability that would benefit the sustainability in franchising between franchisors and franchisees.
Early Education Care from Its Practitioners to Achieve Sustainability
Authors: Gavín-Chocano Óscar , Molero David , García-Martínez Inmaculada
Published: March 2021

(1) Background: Early intervention professionals are involved in the reconceptualisation of their service due to the exceptional situation caused by the COVID-19 epidemic, within the family context and aware of the children’s needs, with an impact on their emotional well-being to ensure sustainability. An analysis of their socio–emotional profile and training is increasingly needed to face their professional development effectively; (2) Methods: In this study, 209 early intervention professionals participated (n = 209), with an average age of 37.62 (±9.02). The following instruments were used: Satisfaction with Life Scale (SWLS), Wong Law Emotional Intelligence Scale (WLEIS-S) and the Utrecht Work Engagement Scale (UWES-9). The purpose of the study was to examine the relationship between early intervention (EI) and engagement as predictors of greater life satisfaction using Structural Equation Modelling (SEM). (3) Results: There exists a relationship between some dimensions of the instruments used (p < 0.01). The model obtained good structural validity (χ² = 3.264; Root Mean Square Error of Approximation (RMSEA) =.021; Goodness-of-Fit Index (GFI) = 0.991; Comparative Goodness of Fit Index (CFI) = 0.999; Incremental Fit Index (IFI) = 0.999). Subsequently, the results described above were verified through Bayesian statistics, thereby reinforcing the evidence provided; (4) Conclusions: Findings highlight the importance of providing professionals with emotional tools and strategies, from the educational context, in order to carry out their activity effectively and ensure the sustainability within the current situation, while remaining fully engaged.
Connected Fundamental Groups and Homotopy Contacts in Fibered Topological (C, R) Space
Authors: Bagchi Susmit
Published: March 2021

The algebraic as well as geometric topological constructions of manifold embeddings and homotopy offer interesting insights about spaces and symmetry. This paper proposes the construction of 2-quasinormed variants of locally dense p-normed 2-spheres within a non-uniformly scalable quasinormed topological (C, R) space. The fibered space is dense and the 2-spheres are equivalent to the category of 3-dimensional manifolds or three-manifolds with simply connected boundary surfaces. However, the disjoint and proper embeddings of covering three-manifolds within the convex subspaces generates separations of p-normed 2-spheres. The 2-quasinormed variants of p-normed 2-spheres are compact and path-connected varieties within the dense space. The path-connection is further extended by introducing the concept of bi-connectedness, preserving Urysohn separation of closed subspaces. The local fundamental groups are constructed from the discrete variety of path-homotopies, which are interior to the respective 2-spheres. The simple connected boundaries of p-normed 2-spheres generate finite and countable sets of homotopy contacts of the fundamental groups. Interestingly, a compact fibre can prepare a homotopy loop in the fundamental group within the fibered topological (C, R) space. It is shown that the holomorphic condition is a requirement in the topological (C, R) space to preserve a convex path-component. However, the topological projections of p-normed 2-spheres on the disjoint holomorphic complex subspaces retain the path-connection property irrespective of the projective points on real subspace. The local fundamental groups of discrete-loop variety support the formation of a homotopically Hausdorff (C, R) space.
A Reduced Dose Whole Virion Aluminum Adjuvanted Seasonal Influenza Vaccine Is Immunogenic, Safe, and Well Tolerated in Pediatric Patients
Authors: Vajo Zoltan , Balaton Gergely , Vajo Peter , Torzsa Peter
Published: March 2021

Background: Data suggest that pediatric patients might react differently to influenza vaccination, both in terms of immunity and side effects. We have recently shown that using a whole virion vaccine with aluminum phosphate adjuvants, reduced dose vaccines containing 6 µg of viral hemagglutinin (HA) per strain are immunogenic, and well tolerated in adult and elderly patients. Here we show the results of a multicenter clinical trial of pediatric patients, using reduced doses of a new, whole virion, aluminum phosphate adjuvanted vaccine (FluArt, Budapest, Hungary). Methods: A total of 120 healthy volunteers were included in two age groups (3–11 years, receiving 3 µg of HA per strain, and 12–18 years, receiving 6 µg of HA per strain). We used hemagglutination inhibition testing to assess immunogenicity, based on EMA and FDA licensing criteria, including post/pre-vaccination geometric mean titer ratios, seroconversion and seropositivity rates. Safety and tolerability were assessed using CHMP guidelines. Results: All subjects entered the study and were vaccinated (ITT population). All 120 subjects attended the control visit on Day 21 (PP population). All immunogenicity licensing criteria were met in both age groups for all three vaccine virus strains. No serious adverse events were detected and the vaccine was well tolerated by both age groups. Discussion: Using a whole virion vaccine and aluminum phosphate adjuvants, a reduction in the amount of the viral hemmaglutinin is possible while maintaining immunogenicity, safety and tolerability in pediatric and adolescent patients.
In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?
Authors: Esteban Ignasi , Pastor-Quiñones Carmen , Usero Lorena , Plana Montserrat , García Felipe , Leal Lorna
Published: March 2021

Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure.
Foamy Viruses, Bet, and APOBEC3 Restriction
Authors: Jaguva Vasudevan Ananda Ayyappan , Becker Daniel , Luedde Tom , Gohlke Holger , Münk Carsten
Published: March 2021

Non-human primates (NHP) are an important source of viruses that can spillover to humans and, after adaptation, spread through the host population. Whereas HIV-1 and HTLV-1 emerged as retroviral pathogens in humans, a unique class of retroviruses called foamy viruses (FV) with zoonotic potential are occasionally detected in bushmeat hunters or zookeepers. Various FVs are endemic in numerous mammalian natural hosts, such as primates, felines, bovines, and equines, and other animals, but not in humans. They are apathogenic, and significant differences exist between the viral life cycles of FV and other retroviruses. Importantly, FVs replicate in the presence of many well-defined retroviral restriction factors such as TRIM5α, BST2 (Tetherin), MX2, and APOBEC3 (A3). While the interaction of A3s with HIV-1 is well studied, the escape mechanisms of FVs from restriction by A3 is much less explored. Here we review the current knowledge of FV biology, host restriction factors, and FV–host interactions with an emphasis on the consequences of FV regulatory protein Bet binding to A3s and outline crucial open questions for future studies.
Only the Best Olive Oil, Please: On New Amphorae Finds From Mursa
Authors: Tonc Asja
Published: March 2021

Large scale rescue excavations in the former Barracks area in present-day Osijek (Mursa) in eastern Croatia yielded important Late La Tène and Roman finds. Thin-walled pottery, terra sigillata and amphorae point to a flourishing 1st c. AD phase of the Roman settlement, especially from the middle of the century until the Flavian era. Amphorae present a small percentage in the recovered pottery, among them dominate those of type Dressel 6B with two stamped pieces. Other types are less common and correspond to the usual type assemblage of other contemporary sites in the region. Since the Dressel 6B type is usually associated with the distribution of olive oil but also to the movements of the Roman army, these examples are used as an opportunity to discuss possible final recipients of the recovered vessels and reflect on the frequency of stamps during the 1st c. AD in Pannonian amphorae samples.