bluuebunny/crossref_metadata_2025 huggingface dataset:
EFEKTIFITAS BIMBINGAN PRA NIKAH TERHADAP ANGKA PERCERAIAN DI KANTOR URUSAN AGAMA (KUA) KECAMATAN SEI BEDUK KOTA BATAM TAHUN 2019
Authors: S Fajri , Pratiwi Diah Ayu , Sutarto Dendi
Published: September 2022

Bimbingan pranikah merupakan tahapan yang wajib sebelum menikah, bimbingan pranikah merupakan tahapan sebagai pengetahuan calon pengantin untuk mempersiapkan hubungan setelah menikah. Kehidupan setelah menikah memiliki peran dan kewajiban, tanggungjawab yang harus dilaksanakan dalam berkeluarga. Mengidentifikasi dan mengetahui program bimbingan pranikah terhadap angka perceraian di Kantor Urusan Agama Kecamatan Sei Beduk Kota Batam Tahun 2019. Penelitian ini akan mendeskripsikan terkait efektivitas bimbingan pranikah dalam indikantor berikut ini, efisiensi, kecukupan, perataan, resposnsivitas, dan ketepatan. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Pengumpulan yang digunakan melalui studi lapangan berupa observasi, wawancara dan dokumentasi. Kantor Urusan Agama Sei Beduk sudah melaksanakan bimbingan pranikah denngan efektif dalam menekan angka perceraian dengan melakukan secara mandiri. Kantor Urusan Agama mewajibkan calon pengantin untuk mengikuti bimbingan pranikah sebelum melaksanakan akad nikah. Bimbingan pranikah merupakan tahapan yang harus dijalankan calon pengantin sebelum akad nikah. Bimbingan pranikah terhadap calon pengantin sangat membantu dalam mempersiapkan calon pengantin untuk menghadapi setelah pernikahan, tujuan dari bimbingan pranikah yang dilakukan oleh Kantor Urusan Agama  Sei Beduk untuk mencegah terjadinya angka perceraian di Kecamatan Sei Beduk.
PEMBERDAYAAN MASYARAKAT DESA MELALUI BUMDES DI DESA SUGAI NIBUNG
Authors: Rahayu Siti , Febrina Rury
Published: September 2022

BUMDes dibangun dengan tujuan untuk menggerakan dan mengakselerasi perekonomian desa. Harapannya segala sumber daya yang dimiliki desa bias di kelola oleh warga desa sendiri untuk meningkatkan pendapatan asli desa , sehingga bisa mandiri. Namun BUMDes yang dirancang sebagai ujung tombak ekonomi desa banyak yang mati sebelum berkembang karena minimya partisipasi warga.BUMDes perlu belajar dari gagalnya praktik institusi-institusi ekonomi desa sebelumnya. Arsitektur kebijakan yang berpola top-down terbukti tidak mampu meningkatkan ekonomi desa. Justru malah menjadi meda kapitalisasi elite desa atas sumber daya yang dimiliki desa. Untuk menuju kemandirian, perlu syarat material berupa partisipasi yang ditopang oleh kepemilikan. Warga desa memiliki hak untuk menjadi pemilik atas sumber daya desanya. Oleh karenanya membangun BUMDes perlu mempertimbangkan kepemilikan yang diperluas. Maka tujuan tersebut bias dilembagakan dengan langkah membangun BUMDes secara inklusif. Mengadaptasi pemberdayaan , warga desa bias menjadi member/pemilik dari BUMDes.
PERAN TOKOH MASYARAKAT DALAM PEMILIHAN CALON LEGISLATIF DI KECAMATAN BURU KABUPATEN KARIMUN
Authors: Andrian Enggi , Wahyuni Sri , Solina Emmy
Published: September 2022

Pada pemilihan legislatif Kabupaten Karimun tahun 2014 salah seorang masyarakat Kecamatan Buru mencalonkan diri menjadi angota legislatif dengan partai pengusung partai Demokrat. Partai Demokrat bukan partai unggulan  didalam pemilihan legislatif di Daerah Pemilihan 1 Kabupaten Karimun. Hal ini dibuktikan dengan pada pemilihan Legislatif sebelumnya tahun 2009 calon dari partai Demokrat tidak ada yang terpilih menjadi angota Legislatif di Daerah Pemilihan 1 Kabupaten Karimun. Pada pemilihan legislatif 2014 dan 2019 calon dari partai Demokrat ini terpilih menjadi angota DPRD  Kabupaten Karimun, terpilihnya calon legislatif dari partai Demokrat ini tidak terlepas dari peran tokoh masyarakat yang telah membantu memperkenalkan calon ke masyarakat  sehingga masyarakat memilih dikarenakan keberadaan dari tokoh masyarakat. Oleh karena itu peneliti tertarik mengetahui lebih dalam peran dari tokoh masyarakat dalam pemilihan calon legislatif di Kecamatan Buru Kabupaten Karimun. Metode dalam penelitian ini menggunakan metode kualitatif, dengan pendekatan Deskriptif karena peneliti ingin memberikan gambaran secara sistematis, faktual, akurat serta data mengenai peran tokoh masyarakat dalam pemilihan calon legislatif di Kecamatan Buru Kabupaten Karimun. Data tersebut peneliti dapatkan melalui wawancara terstruktur mengunakan pedoman wawancara dan observasi terhadap informan. informan peneliti dapatkan melalui teknik purposive sampling. Data yang didapatkan dengan teknik analisis data berupa, peran dari tokoh masyarakat yang telah didapatkan direduksi, agar hanya data yang berkaitan dengan peran tokoh masyarakat yang disajikan dengan narasi dan kemudian ditarik kesimpulannya. Hasil dari penelitian ini yaitu tokoh masyarakat dapat mempengaruhi masyarakat dalam pemilihan legislatif. Peran tokoh masyarakat dalam pemilihan calon legislatif  di Kecamatan Buru Kabupaten Karimun yang peneliti jumpai yaitu: peran dari tokoh masyarakat didalam memenangkan calon legislatif dipengaruhi dengan nilai-nilai masyarakat solidaritas mekanis yaitu ikatan emosional.
Faktor-Faktor Penentu Dalam Mengambil Keputusan Pembelian Mobil Merek Toyota New Avanza Di Kota Batam
Authors: Nasution Habibuddin , Rasal Amrullah
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh harga dan kualitas kualitas produk terhadap keputusan pembelain mobil merek toyota avanza di kota batam. Jenis penelitian ini adalah kuantitatif dan menggunakan analisis regresi berganda. Analisis meliputi: validitas dan reliabilitas, uji asumsi klasik, dan pengujian hipotesis dengan uji t dan f. Penelitian ini menggunakan 156 responden sebagai sampel dari total populasi 250 orang yang telah membeli mobil merek toyota avanza di kota batam. Hasil penelitian menunjukkan bahwa harga dan kualitas produk berpengaruh secara positif dan signifikan terhadap keputusan pembelain mobil merek toyota avanza di kota batam. Secara parsial harga dan kualitas produk berpengaruh terhadap keputusan pembelain mobil merek toyota avanza di kota batam. Kata Kunci: Harga, Kualitas Produk, Keputusan Pembelian. ABSTRACT This study aims to determine the effect of price and product quality on the decision to buy a Toyota Avanza car in Batam City. This type of research is quantitative and uses multiple regression analysis. The analysis includes: validity and reliability, classical assumption test, and hypothesis testing with t and f tests. This study uses 156 respondents as a sample from a total population of 250 people who have bought a Toyota Avanza brand car in Batam City. The results showed that the price and product quality had a positive and significant effect on the decision to buy a Toyota Avanza car in Batam City. Partially the price and product quality affect the decision to buy a Toyota Avanza car in Batam.
Perlindungan Hukum Hak Kekayaan Intelektual Terhadap Budaya Tradisional di Indonesia
Authors: Ardiansyah Irfan
Published: September 2022

Penelitian yang dilakukan pada makalah ini merupakan penelitian normatif. Tulisan ini membahas tentang budaya tradisional Indonesia tidak termasuk perlindungan Hak Kekayaan Intelektual. Hal ini jelas merugikan sebagian masyarakat tradisional. Menyikapi hal tersebut, urgensi perlindungan budaya tradisional tidak bisa lagi sebatas menunggu konsensus internasional, tetapi harus ada beberapa regulasi perlindungan nasional. Pemerintah Indonesia harus bertindak cepat agar budaya tradisional di Indonesia segera mendapat perlindungan hukum. Jenis penelitian yang digunakan pada karya tulis ini adalah penelitian hukum normatif. Jenis pendekatan yang digunakan pada karya tulis ini adalah statue approach. Teknik pengumpulan bahan hukum berupa studi kepustakaan. Temuan Bentuk perlindungan hukum terhadap Budaya Tradisional di Indonesia berdasarkan Undang-Undang Nomor 28 Tahun 2014 telah memberikan perlindungan hukum dalam bentuk pelarangan terhadap pihak asing atau bukan warga negara Indonesia untuk mengumumkan atau memperbanyak ciptaan Budaya Tradisional dari hasil kebudayaan Indonesia.
Gerard Kruisman, pseudoniem Gerard Cruys, 1944-
Authors: Koenders Edith
Published: September 2022

Van meet af aan heeft vertalen een beslissende rol gespeeld in het leven van Gerard Kruisman (ps. Gerard Cruys). Als kind moest hij kunnen switchen tussen het Westfriese dialect, dat werd gesproken in zijn geboortedorp Wervershoof, en het Standaardnederlands. Zijn liefde voor taal motiveerde hem om Slavische Talen en literatuurwetenschap te gaan studeren en de liefde voor een vrouw bracht hem naar Denemarken, waar hij sinds de jaren zeventig woont en werkt. Zijn vertaaloeuvre bestaat uit meer dan zeventig titels uit het Deens, Russisch, Noors en Nederlands en vormt een weerspiegeling van zijn leven. Leven en werk vloeien in elkaar over, of zoals hij het zelf heeft verwoord: ‘Literatuur kan je helpen het leven te begrijpen.’ Het is aan zijn grote toewijding te danken dat de boeken van bijzondere auteurs zoals de Deen Jens Christian Grøndahl en de Rus Michaïl Sjisjkin de Nederlandse lezer hebben kunnen bereiken en verrijken.
DEVELOPMENT OF A COMPREHENSIVE METHOD FOR ASSESSING THE PHYSIOLOGICAL STATE OF THE SKIN
Authors:   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Omelchenko A. V.
Published: September 2022

The objective. Development of a comprehensive method for assessing the impact of external treatments on the functional state of the skin. Materials and methods. The study included 27 healthy people (21 women and 6 people), which were divided into two groups: I – 17 people (Ia - from 18 to 35 years, Ib – from 36–67 years), II – 10 people (IIa – from 18–35 years, IIb -from 36–67 years). And the group received emollient applications with ceramides on the skin of the hands 1–2 times a day for one week. Group II did not apply any external agents to the skin of the hands. All subjects were determined physiological parameters of the skin (moisture, elasticity, smoothness, pigmentation) on the device Aramo TS using Skin XPPRO programs. Results. In all groups at the beginning of the study, the skin was assessed as moderately dehydrated with altered relief and reduced folds and wrinkles. The degree of pigmentation and elasticity of the skin corresponded to the norm. After a week of observation, the moisture of the epidermis was restored in groups Ia and Ib, groups IIa and IIb did not change significantly. The skin relief in persons Ia and Ib groups was better smoothed and corresponded to the limits of the norm, in groups IIa and IIb the indicators remained unchanged. The elasticity of the skin in group I increased, in group II remained unchanged according to the indicators at the beginning of the study. The level of skin pigmentation decreased significantly in group Ia, tended to decrease in group Ib and almost did not change in groups IIa and IIb. Conclusions: The complex technique with the use of instrumental studies of structural and functional parameters of the skin on the device Aramo TS provides an opportunity to objectify the assessment of the impact of external means on the functional state of the skin. The effectiveness of the emollient with ceramides in the subjects under 35 years of age was established, which was more pronounced in comparison with the group of people over 35 years of age.
Pelatihan Penulisan Naskah Ilmiah Jurnal Investigasi Volume 3 Nomor 1 Maret – Juni 2022 bagi Guru-guru se Kota Tangerang Selatan
Authors: Kusjono Gatot , Suprianto Suprianto , Syamruddin Syamruddin
Published: September 2022

Community service activities Scientific Manuscript Writing Training Journal Investigation Volume 3 Number 1 March-June 2022 For Teachers throughout South Tangerang City aims to help elementary / junior high school / junior high school / high school / vocational school teachers in South Tangerang City in writing scientific manuscripts that will be published in journals with ISSN. The training method is carried out using the method of assistance, discussion, workshop and technical guidance (bimtek) of writing scientific manuscripts in accordance with journal manuscript standards. The training results were obtained as many as 8 elementary school teacher manuscripts (62%), 3 junior high school teacher manuscripts (23%), and 2 high school / vocational school teacher manuscripts (15%) published in the journal INVESTIGATION Volume 3 Number 1 March-June 2022. The publication of teachers' scientific manuscripts in the journal INVESTIGATIVE is certainly very helpful for teachers in fulfilling the obligation to journalize their scientific manuscripts, so that they are not constrained in increasing classes or positions.
PERAN DARUD DA’WAH WAL IRSYAD (DDI) DALAM PENGEMBANGAN PENDIDIKAN DI KOTA KENDARI: 1950-2020
Authors: Fatma Fatma , Juma Wa Ode , Wardani Ajeng Kusuma , Arman Arman
Published: September 2022

Permasalahan penelitian ini adalah sebagai berikut: (1) Bagaimana Peran Darud Da’wah Wal Irsyad (DDI) dalam Bidang Pendidikan di Kota Kendari 1950-2020? (2) Apa kendala-kendala yang dihadapi Darud Da’wah Wal Irsyad (DDI)  dalam mengembangkan pendidikan Kota Kendari 1950-2020? Penelitian ini menggunakan metode sejarah yang terdiri dari  lima  tahapan  penelitian,  yaitu:  (a)  Pemilihan  topik,  (b)  Heuristik sumber, (c) Verifikasi sumber, (d) Interpretasi sumber, (e) Historiografi.  Hasil  penelitian  ini  menunjukkan  bahwa:  (1)  Peran DDI dalam pendidikan di Kota Kendari yaitu dengan membangun sekolah-sekolah keagamaan dari tingkat Raudhatul  Athfal (TK), hingga tingkat SMA  seperti Sekolah TK Satria DDI Kota Kendari yang didirikan pada tahun 1992, Sekolah MI DDI Al-Mujahidin Kota Kendari didirikan tahun 2010, Sekolah MTs DDI 2 Bungkutoko yang didirikan pada tahun 1950, sekolah MTs Swasta DDI Kendari  didirikan tahun 1992, sekolah SMA Swasta DDI Kendari didirikan pada tahun 1986, dan sekolah Madrasah Aliyah (MA) DDI Labibia  didirikan pada tahun 2006; (2) Kendala yang dihadapi Darud Da’wah Wal Irsyad (DDI) dalam mengembangkan pendidikan di Kota Kendari yaitu rendahnya sumber daya manusia (SDM) dalam menghadapi perkembangan teknologi, kendala di bidang pendanaan, dan rendahnya minat siswa masuk sekolah.
FUNGSI SOSIAL EKONOMI PELABUHAN LAINO DAN PERKEMBANGANNYA: 1992-2021
Authors: Sindi Sindi , Hamuni Hamuni , Saputri Shinta Arjunita , Marhini La Ode
Published: September 2022

Tujuan penelitian ini yaitu untuk: (1) mengetahui fungsi sosial ekonomi Pelabuhan Rakyat Laino Kabupaten Muna (2) mengetahui perkembangan Pelabuhan Rakyat Laino Kabupaten Muna tahun 1992-2020. Penelitian ini menggunakan metode sejarah yang terdiri dari lima tahapan penelitian yaitu: (a) Pemilihan topik, (b) Heuristik sumber, (c) Verifikasi sumber, (d) Interpretasi sumber, (e) Historiografi. Hasil penelitian ini menunjukkan (1) Pelabuhan Rakyat Laino terletak di Kelurahan Laiworu Kabupaten Muna yang memiliki fungsi sosial dan ekonomi bagi masyarakat Kota Raha khususnya masyarakat Laiworu. secara ekonomi, Pelabuhan Rakyat Laino berfungsi sebagai penggerak roda perekonomian karena memudahkan distribusi hasil-hasil dari Kota Raha ke Kecamatan Maligano, Kecamatan Batu Kara, Kecamatan Pasir Putih, Kecamatan Pasikolaga dan Kecamatan Wakorumba Selatan. Fungsi sosial Pelabuhan Rakyat Laino menjadi fasilitas publik tempat berlangsungnya interaksi antarmasyarakat di Kecamatan Maligano, Kecamatan Batu Kara, Kecamatan Pasir Putih, Kecamatan Pasikolaga dan Kecamatan Wakorumba Selatan. (2) Pelabuhan Rakyat Laino mengalami perkembangan di setiap tahun dimana pada tahun 1992, perkembangan fisik mengalami peningkatan seperti sarana dan prasarana. Perkembangan dari sektor armada laut di Pelabuhan Rakyat Laino juga mengalami peningkatan dalam hal ini, yakni jumlah kapal dan jumlah penumpang di setiap tahun mengalami peningkatan. Pada tahun 1996-2013 Pelabuhan Rakyat Laino mengalami peningkatan pada tahun 1996 sebanyak 4 unit, tahun 2014 sampai dengan 2020 transportasi laut di Pelabuhan Rakyat Laino mengalami perkembangan dari segi ukuran daya tampung kapal dan speed boat. Kemudian penumpang di Pelabuhan Laino Tahun 1992-2021 juga mengalami peningkatan.
Race and Faith: The Role of Congregations in Racial Justice
Authors: Glazier Rebecca , Driskill Gerald , Hanson Dominika
Published: September 2022

In the summer of 2020, catalyzed by the killing of George Floyd, some places of worship more fully entered the conversation on race. Religious traditions often have tools for conflict resolution, repentance, and even reconciliation. How are congregations and religious leaders using the tools of religion to engage questions of racial justice? Our answers come through a multimethod data set collected over two years: (a) surveys of 2,293 congregants from 35 diverse congregations find that race relations is the issue they most want their place of worship to address; (b) 90 sermons from 15 congregations reveal how clergy talked about race in the weeks after Floyd’s murder depended on racial background; (c) 21 clergy interviews illustrate differences in how clergy use religion to engage on racial issues; and (d) interviews with seven national leaders and focus groups with six congregations resulted in a collection of publicly-available faith-based racial justice resources.
Catholic Liberalism
Authors: Bazela Maciej
Published: September 2022

This paper explores the axiological convergence between classical liberalism and Catholic Social Thought (CST). The paper argues that CST and classical liberals should build on their complementary values to strengthen public support for liberal democracy and a free-market economy among Catholic voters and in society at large. Although populist regimes, in particular far-right conservative nationalists, portray liberalism as an antithesis of Catholicism, this paper shows that there is a broad consensus between the two traditions. Contrary to far-right populist positions, it is possible to maintain Catholic values in a liberal market democracy without denouncing one’s religious identity. The paper emphasizes the importance of re-constructing a centrist tradition of Catholic liberal thought to mitigate populist assault on political, economic, and social freedoms.
Computation of Binomial, Factorial and Multinomial Theorems for Machine Leaning and Cybersecurity
Authors: Annamalai Chinnaraji
Published: September 2022

Combinatorial techniques with binomial coefficients, factorials and multinomial computation are used as computing algorithm or cryptographic algorithm for the programs development to apply in artificial intelligence and cybersecurity. Methodological advances in combinatorics and mathematics play a vital role in machine learning and cryptology for data analysis and artificial intelligence-based cybersecurity for protection of the computing systems, devices, networks, programs and data from cyber-attacks. In this article, combinatorial geometric series is discussed more for the application of machine learning and cybersecurity.
Pemetaan Literatur dalam Tesis Manajemen Informasi Perpustakaan
Authors: Rachmaningsih Dewi Maharani
Published: September 2022

Scientific publication must be accountable for its sources, processes and results. This research is based on allegations of diversity citations used in research. These assumptions are influenced by research topics, knowledge development, technology, shifting of the library paradigm, librarian and student competencies. The purpose of this research is to mapping developments literature on thesis Library Information Management (MIP) students. The results of the study can be used as a reference consideration (secondary data) for further research. The research method uses bibliometric citation analysis. Citations are grouped with the help of co-classification mapping theory and will be elaborated descriptively based on predetermined indicators. The total data examined is 63 theses consisting of 2709 literatures. The Indicators used to analyze include the language of literature, the type of literature, the subject of literature, the list of authors along with the title of the essay and the list of publishers. The Citation analysis results include: (1). Analysis of the language of literature is to find out the variety of languages, it can be seen from the increasing use of foreign-language literature. (2). Analysis of the type of literature is to answer the development of literature. (3). Analysis of the subject used to mapping knowledge, the subject is influenced by the research perspective. (4). The essence of the results of the citation analysis using these indicators reveals that the citations in the Information Management and Library thesis of the 2007/2008-2012 / 2013 class vary. The mapping of the literature shows that annually experiencing development, change, and dynamic due to the main factor of technology and student ability.
Analisis Kinerja Aparatur Sipil Negara (ASN) dalam Pembangunan Zona Integritas (ZI) di Kantor Pertanahan Kabupaten Majene
Authors: Putra Amin , Hakim Hamka , Darmanto Darmanto
Published: September 2022

ABSTRAK

Penelitian ini bertujuan untuk menganalisis kinerja ASN dalam pembangunan zona integritas di kantor Pertanahan Kabupaten Majene, menelaah faktor-faktor yang mempngaruh i analisis kinerja ASN dalam pembangunan ZI di Kantor Pertanahan Kabupaten Majene.

Pengumpulan data primer dan data sekunder maka peneliti menggunakan beberapa teknik pengumpulan data melalui observasi yaitu metode yang menitik beratkan pada pengamatan langsung di lokasi penelitian guna melihat dan mengetahui secara pasti, dan wawancara yaitu kegiatan tanya jawab lisan secara langsung kepada informan dengan terlebih dahulu merancang suatu pedoman wawancara yang akan dipakai sebagai panduan untuk menggali informasi yang relevan dengan tujuan penelitian.Wawancara dilakukan adalah untuk mengkonstruksi mengenai seseorang, kejadian, organisasi, perasaan, motivasi, tuntutan, kepedulian: merekonstruksi kebutuhan-kebutuhan sebagai yang telah diharapkan untuk dialami pada masa yang akan datang, memverifikasi, mengubah dan memeperluas informasi yang diperoleh dari orang lain, baik manusia maupun bukan manusia (triangulasi); dan memverifikasi, mengubah dan memperluas konstruksi yang dikembangkan oleh peneliti sebagai pengecekan anggota.

Hasil penelitian menunjukkan bahwa kinerja ASN yang berkaitan dengan aspek hasil kerja, sehubungan dengan pembangunan zona integritas yang  menunjukkan hasil dari pada kerja ASN dalam pembangunan zona integritas tersebut belum terlaksana secara maksimal, Faktor yang mempengaruhi kinerja yaitu faktor individu dan dukungan organisasi terhadap hasil kerja, kedisiplinan dan kerja sama. Faktor individu dimaksudkan adalah kemampuan dan keterampilan, dalam hal pendidikan merupakan salah satu alat ukur penguatan SDM yang dimiliki bagi ASN dalam capaian kinerja yang dapat melahirkan hasil kerja yang diolah dari suatu proses kerja yang dilaksanakan oleh individu dalam mencapai tujuan. Kemudian kedisiplinan yang dimiliki oleh individu ASN juga dapat memberi dampak terhadap kinerja organisasi, kemampuan yang berdasar pada pendidikan sebagai alur berfikir untuk perluasan wawasan individu ASN terhadap proses capaian kinerja individu maupun organisasi, dalam hal ini Kantor Pertanahan Kabupaten Majene.
The Effect of Organizational Commitment, Leadership and Culture Toward Performance of ASN Employees in The Regional Secretariat of Kaltim District
Authors: Gaibu Ilyas
Published: September 2022

This study aims to examine the effect of independent variables which include organizational commitment, leadership style, and organizational culture toward dependent variable, namely employee performance. Research data is primary data in the form of a questionnaire with a Likert scale distributed directly to all research respondents. The sample in this study were employees of the State Civil Apparatus (ASN) within the scope of the Regional Secretariat of East Halmahera Regency with a total of 105 respondents. The data analysis method in this study uses multiple linear regression analysis.The results obtained by the regression equation . The partial analysis results obtained t test, organizational commitment of  leadership style of (6,1434), organizational culture of  table  then  is rejected. So it can be concluded that there is a partial effect on employee performance. While the results of the simultaneous analysis using the F test obtained the calculated F value (69,032) > F table then  s rejected. Thus, it can be concluded that organizational commitment, leadership style, and organizational culture together (F test) has a positive effect on the performance of ASN employees in the Regional Secretariat of East Halmahera district.
Recent advances in engineering nanotopographic substrates for cell studies
Authors: Casanellas Ignasi , Samitier Josep , Lagunas Anna
Published: September 2022

Cells sense their environment through the cell membrane receptors. Interaction with extracellular ligands induces receptor clustering at the nanoscale, assembly of the signaling complexes in the cytosol and activation of downstream signaling pathways, regulating cell response. Nanoclusters of receptors can be further organized hierarchically in the cell membrane at the meso- and micro-levels to exert different biological functions. To study and guide cell response, cell culture substrates have been engineered with features that can interact with the cells at different scales, eliciting controlled cell responses. In particular, nanoscale features of 1–100 nm in size allow direct interaction between the material and single cell receptors and their nanoclusters. Since the first “contact guidance” experiments on parallel microstructures, many other studies followed with increasing feature resolution and biological complexity. Here we present an overview of the advances in the field summarizing the biological scenario, substrate fabrication techniques and applications, highlighting the most recent developments.
A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes
Authors: Rahmatnejad Vida , Tolosa Michael , Ge Xudong , Rao Govind
Published: September 2022

Disposable small-scale vessels are commonly used in cell culture studies in academia as well as early stages of bioprocess development. These types of research are crucial for our understanding about cells and bioprocesses as they provide important information regarding different parameters affecting cells. Dissolved carbon dioxide (DCO2) is one main parameter affecting cell metabolism. It is also an indicator of cell culture well-being. Despite CO2 being a critical process parameter, there is a lack of appropriate monitoring system for CO2 in small-scale vessels. Here, we present a membrane-based noninvasive method for measuring DCO2 in cell culture medium. The idea was achieved by modifying a T-flask and replacing a small area of it with CO2 permeable silicone membrane. In the proposed method, the concentration of CO2 dissolved in the cell culture medium is determined by measuring the initial diffusion rate of CO2 through a silicone membrane attached to the bottom wall of the T-flask. The measurement method was validated previously, and the efficacy of the noninvasive method was evaluated by growing E.coli, Pichia pastoris, and CHO cells in the proposed prototype. The results obtained from this method were verified with other quantitative data obtained from the process such as optical density (OD), cell density, dissolved oxygen (DO) and pH. The results show that the proposed membrane-based method is an effective way for completely noninvasive monitoring of DCO2 in small-scale cell culture processes. Additional diffusing species such as oxygen could also be measured using the same approach.
Regulation and coordination of the different DNA damage responses in Drosophila
Authors: Baonza Antonio , Tur-Gracia Sara , Pérez-Aguilera Marina , Estella Carlos
Published: September 2022

Cells have evolved mechanisms that allow them to respond to DNA damage to preserve genomic integrity and maintain tissue homeostasis. These responses include the activation of the cell cycle checkpoints and the repair mechanisms or the induction of apoptosis that eventually will eliminate damaged cells. These “life” vs. “death” decisions differ depending on the cell type, stages of development, and the proliferation status of the cell. The apoptotic response after DNA damage is of special interest as defects in its induction could contribute to tumorigenesis or the resistance of cancer cells to therapeutic agents such as radiotherapy. Multiples studies have elucidated the molecular mechanisms that mediate the activation of the DNA damage response pathway (DDR) and specifically the role of p53. However, much less is known about how the different cellular responses such as cell proliferation control and apoptosis are coordinated to maintain tissue homeostasis. Another interesting question is how the differential apoptotic response to DNA damage is regulated in distinct cell types. The use ofDrosophila melanogasteras a model organism has been fundamental to understand the molecular and cellular mechanisms triggered by genotoxic stress. Here, we review the current knowledge regarding the cellular responses to ionizing radiation as the cause of DNA damage with special attention to apoptosis inDrosophila: how these responses are regulated and coordinated in different cellular contexts and in different tissues. The existence of intrinsic mechanisms that might attenuate the apoptotic pathway in response to this sort of DNA damage may well be informative for the differences in the clinical responsiveness of tumor cells after radiation therapy.
PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease
Authors: Li Ke , Ran Beibei , Wang Yu , Liu Lulu , Li Weidong
Published: September 2022

Alzheimer’s disease (AD) is an irreversible neurodegenerative disease mainly characterized by memory loss and cognitive decline. The etiology of AD is complex and remains incompletely understood. In recent years, genome-wide association studies (GWAS) have increasingly highlighted the central role of microglia in AD pathology. As a trans-membrane receptor specifically present on the microglia in the central nervous system, phosphatidylinositol-specific phospholipase C gamma 2 (PLCγ2) plays an important role in neuroinflammation. GWAS data and corresponding pathological research have explored the effects of PLCG2 variants on amyloid burden and tau pathologies that underline AD. The link between PLCγ2 and other AD-related effectors in human and mouse microglia has also been established, placing PLCγ2 downstream of the triggering receptor expressed on myeloid cells 2 (TREM2), toll-like receptor 4 (TLR4), Bruton’s tyrosine kinase (BTK), and colony-stimulating factor 1 receptor (CSF1R). Because the research on PLCγ2’s role in AD is still in its early stages, few articles have been published, therefore in this paper, we integrate the relevant research published to date, review the structural features, expression patterns, and related pathways of PLCγ2, and summarize the recent studies on important PLCG2 variants related to AD. Furthermore, the possibility and challenge of using PLCγ2 to develop therapeutic drugs for AD are also discussed.
A peptide-DNA hybrid bio-nanomicelle and its application for detection of caspase-3 activity
Authors: Zhang Fan , Mao Changqing , Cao Siyu , Zhang Runchi , Guo Yi , Chen Guifang , Feng Chang
Published: September 2022

Bio-nanomicelles based on biomaterials such as nucleic acids, peptides, glycans, and lipids have developed rapidly in the field of bioanalysis. Although DNA and peptides have unique advantages, unfortunately, there are few bio-nanomicelles integrating DNA with peptides. Here, we designed a peptide-DNA hybrid bio-nanomicelle for the activity detection of caspase-3. The detection mechanism is based on caspase-3 specific recognition and cleavage of peptide substrates, which owns high sensitivity and selectivity. Under optimal conditions, the detection of caspase-3 activity can be achieved using our designed bio-nanomicelles and the detection limit is 0.72 nM. Furthermore, the proposed method was also successfully applied for the detection of caspase-3 in cell lysate samples after apoptosis-inducing.
Cinefluoroscopy for assessment of mechanical heart valves with suspected dysfunction
Authors: Derda Anselm A. , Marquardt Marvin M. , Martens Andreas , Mirena Elion , Vogel-Claussen Jens , Kempf Tibor , Haverich Axel , Bauersachs Johann , Napp L. Christian
Published: September 2022

Background

Mechanical heart valves (MHVs) are preferred prosthesis types in many, especially younger patients who need surgical valve replacement. Although echocardiography is most frequently performed for prosthesis assessment during follow-up, ultrasound artifacts usually preclude a precise investigation of prosthesis function. Cinefluoroscopy (CF) is a simple and effective method to analyze and quantify opening and closing of prosthesis leaflets but requires careful visualization of the valve using optimal viewing angles. Here, we investigated the quality of CF studies in clinical routine and their suitability for quantitative analysis of prosthesis function.

Methods and results

We retrospectively identified 94 patients with 118 cinefluoroscopies performed by 31 different investigators in one tertiary center from 2012 to 2021. Of 150 MHVs (98% bi-leaflet prostheses), 87 (58%) were aortic, 53 (34%) mitral, 7 (5%) tricuspid, and 5 (3%) pulmonary valve prostheses, respectively. CF studies were categorized by their suitability to quantitatively assess opening and closing angles. Visualization of valve function was “sufficient” in 23%, “suboptimal” in 46%, and “unsuitable” in 31% of the cases.

Conclusion

In clinical routine, only one-fourth of CF studies allow for a complete assessment of leaflet motion of MHVs. Although this may be in part due to the varying experience of operators, the high number of unsuitable studies suggests that optimal viewing angles may not be achievable in all patients. Further research is required to investigate standard viewing angles and anatomy after MHV implantation to improve the quality of CF studies and reduce radiation exposure of patients and operators.
Concomitant transcatheter occlusion versus thoracoscopic surgical clipping for left atrial appendage in patients undergoing ablation for atrial fibrillation: A meta-analysis
Authors: Zhang Shijie , Cui Yuqi , Li Jinzhang , Tian Hongbo , Yun Yan , Zhou Xiaoming , Fang Hui , Zhang Haizhou , Zou Chengwei , Ma Xiaochun
Published: September 2022

Background

Both catheter left atrial appendage occlusion combined with ablation (COA) and thoracoscopic surgical left atrial appendage clipping combined with ablation (TCA) have shown favorable outcomes in management of patients with atrial fibrillation (AFib). However, studies comparing the endpoints of both techniques are still lacking. Herein, a meta-analysis of safety and efficacy outcomes of COA versus TCA was performed in patients with AFib.

Methods

Pubmed, Embase, Cochrane, and Web of Science databases were searched for retrieving potential publications. The primary outcome was the incidence of stroke during follow-up period of at least 12 months. Secondary outcomes were acute success rate of complete left atrial appendage (LAA) closure by COA or TCA, postprocedural mortality and complications, and all-cause mortality during follow-up period of at least 12 months.

Results

19 studies of COA containing 1,504 patients and 6 studies of TCA with 454 patients were eligible for analysis. No significant difference in stroke and all-cause mortality was found in patients undergoing COA versus TCA after at least a 12-month follow-up (stroke: p = 0.504; all-cause mortality: p = 0.611). COA group had a higher acute success rate compared with TCA group (p = 0.001). COA placed the patients at a higher risk of hemorrhage during the postprocedural period compared with TCA (p = 0.023). A similar risk of other postprocedural complications (stroke/transient ischemic attack and pericardial effusion) and mortality was found in the COA group in comparison with TCA group (p>0.05).

Conclusion

This meta-analysis showed that COA and TCA did not differ in stroke prevention and all-cause mortality in patients with AFib after a follow-up of at least 12 months. Postprocedural complications and mortality were almost comparable between the two groups. In the near future, high-quality randomized controlled trials exploring the optimal surgical strategies for AFib and endpoints of different procedures are warranted.

Systematic review registration

[https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42022325497].
Transforming growth factor serum concentrations in patients with proven non-syndromic aortopathy
Authors: Karalko Mikita , Pojar Marek , Zaloudkova Lenka , Stejskal Vaclav , Timbilla Salifu , Brizova Pavla , Vojacek Jan
Published: September 2022

Background

The mechanism underlying aortic dilatation is still unknown. Vascular dilatation is thought to be the result of progressive aortic media degeneration caused by defective vascular matrix hemostasis, including TGF-β1 dysregulation. The goal of this study is to draw attention to the potential utility of TGF-β1 as a diagnostic marker in non-syndromic patients with aortic dilatation.

Methods

TGF-β1 levels in plasma were measured in 50 patients who had undergone surgery and had a tricuspid or bicuspid aortic valve as well as a normal or dilated ascending aorta. A pathologist also examined thirty resected aorta samples. To specify the reference range of TGF-β1, a control group of 40 volunteers was enrolled in this study.

Results

We discovered a significant difference in TGF-β1 levels between patients with aortic dilatation and the control group (32.5 vs. 63.92;P< 0.001), as well as between patients with non-dilated aorta but with aortic valve disease, and the control group (27.68 vs. 63.92;P< 0.001). There was no difference between the dilated ascending aorta group and the non-dilated ascending aorta group. We found a poor correlation between TGF-β1 levels and ascending aorta diameter as well as the grade of ascending aorta histopathological abnormalities.

Conclusion

TGF-β1 concentration does not meet the criteria to be a specific marker of aortic dilatation, but it is sensitive to aortic valvulopathy-aortopathy. A larger patient cohort study is needed to confirm these findings.
Variation of luminescence sensitivity of quartz grains from loess in eastern Tibetan Plateau and its provenance significance
Authors: Liu Li , Yang Shengli , Liu Xiaojing , Li Pushuang , Wang Haiyan , Zhou Jiantao
Published: September 2022

The loess deposits widely distributed in the eastern Tibetan Plateau (ETP) are important archives for reconstructing the paleoenvironmental changes and dust transportation history of the Tibetan Plateau. A lack of sufficient investigations on the source of the ETP loess has limited our understanding of dust transportation and paleoenvironmental implications. Quartz luminescence sensitivity holds great potential for tracing eolian dust sources. Numerous quartz luminescence sensitivity investigations have provided new insights into the dust sources and transportation of the Chinese loess. However, studies on luminescence sensitivity and its significance for the ETP loess provenance are scarce. In this work, we selected quartz grains in loess from different sites of the ETP to investigate the variation of luminescence sensitivity by testing the 110°C thermoluminescence (TL) peak and optically stimulated luminescence (OSL) sensitivities of quartz grains and discussed the provenance implications for the ETP loess based on quartz luminescence sensitivities. Our results show the quartz luminescence sensitivities of loess at different locations were significantly different in the ETP. The luminescence sensitivity values of the Machang (MC), Xiaojin (XJ), and Wenchuan (WCH) sections were much higher than those of the Xinshi (XS) and Zhouqu (ZQ) sections. The sensitivity values of the 110°C TL peaks and OSL in the paleosol and loess layers show distinct differences. The quartz luminescence sensitivities of the ETP loess are mainly influenced by the dust sources. Our results show that the luminescence sensitivities of quartz grains have great potential for identifying the loess sources in the ETP.
Hierarchically porous carbon nanofiber binder-free electrode for high-performance lithium–sulfur batteries
Authors: Xiao Ming , Li Ruixue , Dai Yu , Yang Ting
Published: September 2022

It is still a challenge for lithium–sulfur (Li-S) batteries to possess high sulfur utilization and excellent electrochemical performances due to the low electrical conductivity and dissolution of polysulfides. To resolve these issues, a free-standing sulfur host composed of hierarchically porous carbon nanofibers (HPCNFs) has been synthesized via electrospinning technology. The HPCNFs with an interconnected and porous structure can facilitate electron transfer and electrolyte penetration. The mesopores in HPCNFs can provide high levels of sulfur loading, and the micropores can inhibit shuttle effects of the sulfur cathode during discharge and charge processes. After encapsulating a high mass of sulfur (76.4 wt%, HPCNFs@S), the electrode was directly applied as a cathode for the Li-S battery, which exhibited a high specific discharge capacity of 1,145 mA h g−1 at 0.1 C (1 C = 1,675 mA g−1) and maintained 787 mA h g−1 after 150 charge/discharge cycles. This work provides a new insight into optimizing the electrochemical performance of Li-S batteries.
Stator single-line-to-ground fault protection for powerformers based on HSGC and CNN
Authors: Liu Xiaohan , Wang Yuanyuan , Luo Xiaomin , Cao Chengjun , Li Wei , Wang Buming , Wang Jiabao , Wang Yin
Published: September 2022

It is necessary for powerformers running in parallel to identify which powerformer occurs at the stator single-line-to-ground (SLG) fault. Some state-of-the-art fusion discriminations are used to identify stator SLG fault, but these methods extract fault features artificially, and application conditions are limited. Convolutional neural network (CNN) has shown superior automatic feature extraction ability in various fields, but it cannot directly extract features from one-dimensional time series vectors collected by powerformers. Therefore, this article proposed a novel SLG fault protection scheme based on the hub-and-spoke grid data converting algorithm (HSGC) and CNN. First, Pearson product-moment correlation coefficients (PCCs) are used to calculate the correlations of one-dimensional time series vectors, establish a correspondence between them and the distance of two-dimensional grid cells, and then convert one-dimensional time series vectors to two-dimensional grid-structured data by HSGC. Second, the trained CNN automatically extracts the features of two-dimensional grid-structured data. Finally, the faulty powerformer can be identified based on the output of CNN. The proposed protection scheme is verified through the simulation of ATP-EMTP and Python. The results show that the scheme can accurately detect a faulty Powerformer under different conditions where neutral point is high-resistance or reactance grounding, even if fault resistance is 8,000 Ω.
National accounting scheme for biodiversity loss: An international trade perspective
Authors: Li Xuemei , Xing Lu , Zhang Zhe , Zhang Ying
Published: September 2022

International trade has emerged as a threat to biodiversity. Identifying the biodiversity loss in countries/regions driven by international trade is a prerequisite for effective protection. Considering the lack of existing research, it is urgently necessary to construct an equitable and reasonable accounting scheme for biodiversity loss. Therefore, based on the multi-regional input–output model framework, this study uses the International Union for Conservation of Nature Red List of Threatened Species data to evaluate and compare the biodiversity footprints of 188 countries/regions between 2006 and 2015. We find that the world’s biodiversity footprint is characterized by a significant spatial non-equilibrium driven by developed countries and developing countries with large economies. Financial intermediation and business activities, education, health, and other services, and construction and agriculture sectors play an important role in the accounting scheme for biodiversity and hence must be strictly controlled. This study will help construct a biodiversity conservation framework in the 2020s.
Laying it on thick: Ecosystem effects of sediment placement on a microtidal Rhode Island salt marsh
Authors: Raposa Kenneth B. , Bradley Michael , Chaffee Caitlin , Ernst Nick , Ferguson Wenley , Kutcher Thomas E. , McKinney Richard A. , Miller Kenneth M. , Rasmussen Scott , Tymkiw Elizabeth , Wigand Cathleen
Published: September 2022

Heightened recognition of impacts to coastal salt marshes from sea-level rise has led to expanding interest in using thin-layer sediment placement (TLP) as an adaptation tool to enhance future marsh resilience. Building on successes and lessons learned from the Gulf and southeast U.S. coasts, projects are now underway in other regions, including New England where the effects of TLP on marsh ecosystems and processes are less clear. In this study, we report on early responses of a drowning, microtidal Rhode Island marsh (Ninigret Marsh, Charlestown, RI) to the application of a thick (10–48 cm) application of sandy dredged material and complimentary extensive adaptive management to quickly build elevation capital and enhance declining high marsh plant species. Physical changes occurred quickly. Elevation capital, rates of marsh elevation gain, and soil drainage all increased, while surface inundation, die-off areas, and surface ponding were greatly reduced. Much of the marsh revegetated within a few years, exhibiting aspects of classic successional processes leading to new expansive areas of high marsh species, although low marshSpartina alterniflorarecovered more slowly. Faunal communities, including nekton and birds, were largely unaffected by sediment placement. Overall, sediment placement provided Ninigret Marsh with an estimated 67–320 years of ambient elevation gain, increasing its resilience and likely long-term persistence. Project stakeholders intentionally aimed for the upper end of high marsh plant elevation growth ranges to build elevation capital and minimize maintenance costs, which also resulted in new migration corridors, providing pathways for future marsh expansion.
Promoting sustainable entrepreneurship in training and education: The role of entrepreneurial culture
Authors: Zahrani Aida Ahmed
Published: September 2022

The main purpose of this research was to investigate how universities may help Saudi Arabian students who are planning to become entrepreneurs promote sustainability development goals. The intersection of ecological development and entrepreneurship is referred to as “sustainable entrepreneurship.” Entrepreneurs want to provide practical educational solutions. Thus, this study seeks to fill this gap by developing a new model for measuring the relationships between entrepreneurial culture, sustainability training, and sustainability education in Saudi Arabia. A quantitative research “survey questionnaire” found in the human relations theory of sustainable entrepreneurship was used to collect data. This study looked at the impact of three dimensions connected to the role of entrepreneurship in higher education using AMOS and Structural Equation Modelling (SEM). The data (n= 252) was examined using AMOS and SEM. Therefore, this study specifies 37 items, three of which are the most important. 1) a sustainable entrepreneurial culture, 2) sustainability training, and 3) sustainability education. The findings imply that a sustained entrepreneurial culture has a good influence on training and education. Furthermore, sustainability training has a good influence on sustainability education. As a result, this research supports the extended human relations theory of the function of a sustainable entrepreneurial culture by indicating that the model anticipates university students increasing their entrepreneurial cultureviatraining and education in higher education.