bluuebunny/crossref_metadata_2025 huggingface dataset:
Conformal Dose Modulator for Proton Beam Therapy Part 1: A Simulation Study
Authors: Zhang Zhexuan , Zhao Weizhao , Butkus Michael , Wu Xiaodong
Published: April 2022

Purpose

Conformal dose deliveries in proton therapy utilize either a passive scattering system with a modulator or a pencil beam scanning (PBS) system. Efforts have been made to achieve conformal dose delivery by scanning a single energy layer of pencil beams through a 3D conformal modulator (3DCM), which combines a spread-out Bragg peak (SOBP) modulator consisting of a micro-pyramid array and a range compensator. The current published approach of designing such 3DCM relies on forward calculation methods to determine the geometry of the modulator. This study presents an alternative designing algorithm that inversely generates the geometry of a 3DCM paired with a corresponding fluence map, customized to patient-specific clinical indications.

Methods

Critical spacing governing the size and separation between neighboring micro-pyramids was first determined, under which the dose homogeneity at desired depths could be achieved. We designed an adaptive ring optimization method using a modified gradient descent algorithm to inversely calculate the geometry of the 3DCM. This method includes several stages that progressively optimize both target coverage and dose conformity. The output contains the geometry of the 3DCM and its corresponding proton fluence map. Monte Carlo (MC) simulation was used to validate the results.

Results

The critical size and spacing of Lucite pyramids was determined to be 0.5 cm for a 184-MeV pristine proton beam. Using MATLAB (R2020a), the inverse designing algorithm generated an optimized 3DCM geometry and a fluence distribution achieving 100% target coverage with the 90% isodose surface and a corresponding conformity index of 1.057 on a spherical target. The resulting geometry was pruned to accommodate the MC simulation software and a currently accessible 3D printing service. The pruned geometry gave 95% target coverage by 90% isodose surface with a conformity index of 1.09 by ray-tracing dose computation. The MC simulation validated the 3DCM with 95% target coverage by 87% isodose surface and a conformity index of 1.12.

Conclusion

We have demonstrated the feasibility of using a novel inverse optimization algorithm to generate 3DCM geometry and its corresponding proton beam fluence/intensity map, which could deliver highly conformal dose distribution with pencil beam scanning system using a single energy layer.
MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer
Authors: Wang Tao , Zhang Peng , Li Chengguo , Liu Weizhen , Shen Qian , Yang Lei , Xie Gengchen , Bai Jie , Li Ruidong , Tao Kaixiong , Yin Yuping
Published: April 2022

MUS81 is a critical endonuclease involved in heterodimer formation with Eme1/Mms4 and an important DNA damage repair regulatory molecule. Our previous study suggested that MUS81 was overexpressed and its high expression was positively correlated with gastric cancer metastasis. However, the therapeutic potential of targeting MUS81 in gastric cancer requires further exploration. Therefore, in this study, the Cancer Genome Atlas (TCGA) data were analyzed and showed that MUS81 is a key regulator of cell cycle distribution and DNA damage repair in gastric cancer. In vitro and in vivo, MUS81 knockdown significantly enhanced the anticancer effect of the PARP inhibitor talazoparib. Mechanistically, MUS81 inhibition impaired the activation of the ATR/CHK1 cell cycle signaling pathway and promoted gastric cancer cells with talazoparib-induced DNA damage to continue mitosis. Moreover, addition of the bromodomain-containing protein 4 inhibitor AZD5153 increased the anticancer effect of talazoparib via MUS81 inhibition in gastric cancer cells, and this combination effect was largely impaired when MUS81 was knocked down. In conclusion, these data suggested that MUS81 regulated ATR/CHK1 activation, a key signaling pathway in the G2M checkpoint, and targeting MUS81 enhanced the antitumor efficacy of talazoparib. Therefore, AZD5153 combined with talazoparib may represent a promising therapeutic strategy for patients with MUS81 proficient gastric cancer.
A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer
Authors: Zuppone Stefania , Assalini Chiara , Minici Claudia , Botrugno Oronza A. , Curnis Flavio , Degano Massimo , Corti Angelo , Montorsi Francesco , Salonia Andrea , Vago Riccardo
Published: April 2022

Although toxin may have some advantages compared to chemotherapeutic drugs in cancer therapy, e.g. a potent cytotoxic activity and a reduced risk of resistance, their successful application in the treatments to solid tumors still remains to be fully demonstrated. In this study, we genetically modified the structure of the plant-derived single-chain ribosome inactivating protein saporin (SAP) by fusing its N-terminus to the ACDCRGDCFCG peptide (RGD-4C), an αv-integrin ligand, and explored the anti-tumor activity of the resulting protein (called RGD-SAP) in vitro and in vivo, using a model of muscle invasive bladder cancer. We found that the RGD-4C targeting domain enhances the cytotoxic activity of SAP against various tumor cell lines, in a manner dependent on αv-integrin expression levels. In a subcutaneous syngeneic model of bladder cancer, RGD-SAP significantly reduced tumor growth in a dose-dependent manner. Furthermore, systemic administration of RGD-SAP in combination with mitomycin C, a chemotherapeutic drug currently used to treat patients with bladder cancer, increased the survival of mice bearing orthotopic bladder cancer with no evidence of systemic toxicity. Overall, the results suggest that RGD-SAP represents an efficient drug that could be exploited, either alone or in combination with the state-of-the-art therapies, for the treatment of bladder cancer and, potentially, of other solid tumors.
A Novel Nomogram for Prediction and Evaluation of Lymphatic Metastasis in Patients With Renal Cell Carcinoma
Authors: Li Wenle , Wang Bing , Dong Shengtao , Xu Chan , Song Yang , Qiao Ximin , Xu Xiaofeng , Huang Meijin , Yin Chengliang
Published: April 2022

Background

Lymphatic metastasis is an important mechanism of renal cell carcinoma (RCC) dissemination and is an indicator of poor prognosis. Therefore, we aimed to identify predictors of lymphatic metastases (LMs) in RCC patients and to develop a new nomogram to assess the risk of LMs.

Methods

This study included patients with RCC from 2010 to 2018 in the Surveillance, Epidemiology, and Final Results (SEER) database into the training cohort and included the RCC patients diagnosed during the same period in the Second Affiliated Hospital of Dalian Medical University into the validation cohort. Univariate and multivariate logistic regression analysis were performed to identify risk factors for LM, constructing a nomogram. The receiver operating characteristic (ROC) curves were generated to assess the nomogram’s performance, and the concordance index (C-index), area under curve value (AUC), and calibration plots were used to evaluate the discrimination and calibration of the nomogram. The nomogram’s clinical performance was evaluated by decision curve analysis (DCA), probability density function (PDF) and clinical utility curve (CUC). Furthermore, Kaplan-Meier curves were performed in the training and the validation cohort to evaluate the survival risk of the patients with lymphatic metastasis or not. Additionally, on the basis of the constructed nomogram, we obtained a convenient and intuitive network calculator.

Results

A total of 41837 patients were included for analysis, including 41,018 in the training group and 819 in the validation group. Eleven risk factors were considered as predictor variables in the nomogram. The nomogram displayed excellent discrimination power, with AUC both reached 0.916 in the training group (95% confidence interval (CI) 0.913 to 0.918) and the validation group (95% CI 0.895 to 0.934). The calibration curves presented that the nomogram-based prediction had good consistency with practical application. Moreover, Kaplan-Meier curves analysis showed that RCC patients with LMs had worse survival outcomes compared with patients without LMs.

Conclusions

The nomogram and web calculator (https://liwenle0910.shinyapps.io/DynNomapp/) may be a useful tool to quantify the risk of LMs in patients with RCC, which may provide guidance for clinicians, such as identifying high-risk patients, performing surgery, and establishing personalized treatment as soon as possible.
In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis
Authors: Moubarak Rana S. , Koetz-Ploch Lisa , Mullokandov Gavriel , Gaziel Avital , de Pablos-Aragoneses Ana , Argibay Diana , Kleffman Kevin , Sokolova Elena , Berwick Marianne , Thomas Nancy E. , Osman Iman , Brown Brian D. , Hernando Eva
Published: April 2022

Melanoma is a highly prevalent cancer with an increasing incidence worldwide and high metastatic potential. Brain metastasis is a major complication of the disease, as more than 50% of metastatic melanoma patients eventually develop intracranial disease. MicroRNAs (miRNAs) have been found to play an important role in the tumorigenicity of different cancers and have potential as markers of disease outcome. Identification of relevant miRNAs has generally stemmed from miRNA profiling studies of cells or tissues, but these approaches may have missed miRNAs with relevant functions that are expressed in subfractions of cancer cells. We performed an unbiased in vivo screen to identify miRNAs with potential functions as metastasis suppressors using a lentiviral library of miRNA decoys. Notably, we found that a significant fraction of melanomas that metastasized to the brain carried a decoy for miR-124a, a miRNA that is highly expressed in the brain/neurons. Additional loss- and gain-of-function in vivo validation studies confirmed miR-124a as a suppressor of melanoma metastasis and particularly of brain metastasis. miR-124a overexpression did not inhibit tumor growth in vivo, underscoring that miR-124a specifically controls processes required for melanoma metastatic growth, such as seeding and growth post-extravasation. Finally, we provide proof of principle of this miRNA as a promising therapeutic agent by showing its ability to impair metastatic growth of melanoma cells seeded in distal organs. Our efforts shed light on miR-124a as an antimetastatic agent, which could be leveraged therapeutically to impair metastatic growth and improve patient survival.
Metformin Regulates TET2 Expression to Inhibit Endometrial Carcinoma Proliferation: A New Mechanism
Authors: Zhang Jingbo , Kuang Lei , Li Yanyu , Wang Qing , Xu Hui , Liu Jianwei , Zhou Xueyan , Li Yang , Zhang Bei
Published: April 2022

Objectives

To investigate the relationship between TET2 expression and endometrial cancer’s clinicopathological features and prognosis, and the effect of metformin on TET2 and 5hmC levels in endometrial cancer cells.

Methods

The clinical significance of TET2 expression in endometrial carcinoma was analyzed from TCGA public database. Eighty-eight patients with endometrial cancer and 20 patients with normal proliferative endometrium were enrolled in this study. TET2 and 5hmC were respectively detected by Immunohistochemistry and ELISA in endometrial tissues. Kaplan-Meier and Cox proportional hazard regression models were used to analyze relationships between TET2 and 5hmC and the overall survival of EC patients. Endometrial cell proliferation was assessed after TET2 gene knockdown. Western blotting and real-time PCR were used to detect the effect of metformin on TET2 expression and to explore whether AMPK is involved in metformin-mediated TET2 regulation.

Results

The clinical significance of expression of TET2 in endometrial cancer from TCGA public database confirmed that TET2 expression was significantly down-regulated in cancer samples and TET2 expression was also significantly different among different histopathological samples and TET2 is down-regulated in advanced, high-grade, and relapsed endometrial carcinoma tissues(P<0.05). Immunohistochemical analysis showed that TET2 and 5hmC levels were significantly lower in endometrial adenocarcinoma(P<0.05). TET2 expression was correlated with the degree of EC differentiation (P < 0.05). 5hmC levels were associated with clinical stage, differentiation, the depth of myometrial invasion, and lymph node metastasis (P < 0.05). The mean survival time of patients with negative staining for TET2 and 5hmC was shorter than that of patients with positive staining for both markers (P<0.05). Multivariate Cox regression analysis showed that TET2 expression was an independent risk factor for prognosis in patients with endometrial adenocarcinoma (HR = 14.520, 95% CI was 1.From 060 to 198.843, P = 0.045). siRNA-mediated TET2 knockdown increased the proliferation of EC cells. Metformin increased the levels of TET2 and 5hmC in EC cells. AMPK was involved in the regulation of TET2 by metformin.

Conclusions

TET2 may play an important role in EC development and may be a prognostic marker. Moreover, TET2 may be involved in a novel mechanism by which metformin inhibits EC cell proliferation.
Mechanisms and Therapeutic Strategies of Viral Myocarditis Targeting Autophagy
Authors: Yu Kun , Zhou Ling , Wang Yinhui , Yu Chengxin , Wang Ziyi , Liu Hao , Wei Haoran , Han Liang , Cheng Jia , Wang Feng , Wang Dao Wen , Zhao Chunxia
Published: April 2022

Viral myocarditis is caused by infection with viruses or bacteria, including coxsackievirus B3 (CVB3), and is characterized by acute or chronic inflammatory responses in the heart. The mortality associated with severe viral myocarditis is considerable. In some patients, viral myocarditis may develop into dilated cardiomyopathy or heart failure. Autophagy is involved in a wide range of physiological processes, including viral infection and replication. In the present review, we focus on the responses of cardiac tissues, cardiomyocytes, and cardiac fibroblasts to CVB3 infection. Subsequently, the effects of altered autophagy on the development of viral myocarditis are discussed. Finally, this review also examined and assessed the use of several popular autophagy modulating drugs, such as metformin, resveratrol, rapamycin, wortmannin, and 3-methyladenine, as alternative treatment strategies for viral myocarditis.
Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension via STAT3/HIF-1α/VEGF and FAK/AKT Signaling Pathways
Authors: Wang Ran-Ran , Yuan Tian-Yi , Chen Di , Chen Yu-Cai , Sun Shu-Chan , Wang Shou-Bao , Kong Ling-Lei , Fang Lian-Hua , Du Guan-Hua
Published: April 2022

Traditional Chinese medicine (TCM) plays an important role in the treatment of complex diseases, especially cardiovascular diseases. However, it is hard to identify their modes of action on account of their multiple components. The present study aims to evaluate the effects of Dan-Shen-Yin (DSY) granules on hypoxia-induced pulmonary hypertension (HPH), and then to decipher the molecular mechanisms of DSY. Systematic pharmacology was employed to identify the targets of DSY on HPH. Furthermore, core genes were identified by constructing a protein-protein interaction (PPI) network and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analysis. Related genes and pathways were verified using a hypoxia-induced mouse model and hypoxia-treated pulmonary artery cells. Based on network pharmacology, 147 potential targets of DSY on HPH were found, constructing a PPI network, and 13 hub genes were predicted. The results showed that the effect of DSY may be closely associated with AKT serine/threonine kinase 1 (AKT1), signal transducer and activator of transcription 3 (STAT3), and HIF-1 signaling pathways, as well as biological processes such as cell proliferation. Consistent with network pharmacology analysis, experiments in vivo demonstrated that DSY could prevent the development of HPH in a hypoxia-induced mouse model and alleviate pulmonary vascular remodeling. In addition, inhibition of STAT3/HIF-1α/VEGF and FAK/AKT signaling pathways might serve as mechanisms. Taken together, the network pharmacology analysis suggested that DSY exhibited therapeutic effects through multiple targets in the treatment of HPH. The inferences were initially confirmed by subsequent in vivo and in vitro studies. This study provides a novel perspective for studying the relevance of TCM and disease processes and illustrates the advantage of this approach and the multitargeted anti-HPH effect of DSY.
A Dual-Polarized Horn Antenna Covering Full Ka-Band Using Turnstile OMT
Authors: Xiao Jun , Teni Geer , Li Hongmei , Ding Tongyu , Ye Qiubo
Published: April 2022

This article presents a dual-polarized corrugated horn antenna incorporated a turnstile orthomode transducer (OMT) covering the full Ka-band (26.5–40 GHz). A three-stepped cylindrical tuning stub scattering element is designed in the turnstile junction to combine/split the two linearly polarized waves with high isolation. The proposed turnstile OMT shows a good simulated return loss better than 20 dB and a high isolation higher than 57 dB within the whole Ka-band. Then, a corrugated horn antenna with five-stage choke rings is designed. Finally, the proposed horn antenna incorporated in the turnstile OMT is fabricated and measured. The measured impedance bandwidth for |S11/22|≤ −15 dB is 50.7% from 25 to 42 GHz. The measured peak gain is 11.9 dBi. The proposed antenna system is a promising candidate for the 5G millimeter-wave applications.
Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction
Authors: Centner Christoph , Jerger Simon , Mallard Alistair , Herrmann Anna , Varfolomeeva Eugenia , Gollhofer Sandra , Oesser Steffen , Sticht Carsten , Gretz Norbert , Aagaard Per , Nielsen Jakob L. , Frandsen Ulrik , Suetta Charlotte , Gollhofer Albert , König Daniel
Published: April 2022

Previous evidence suggests that resistance training in combination with specific collagen peptides (CP) improves adaptive responses of the muscular apparatus. Although beneficial effects have been repeatedly demonstrated, the underlying mechanisms are not well understood. Therefore, the primary objective of the present randomized trial was to elucidate differences in gene expression pathways related to skeletal muscle signal transduction following acute high-load resistance exercise with and without CP intake. Recreationally active male participants were equally randomized to high-load leg extension exercise in combination with 15 g CP or placebo (PLA) supplementation. Muscle biopsies from the vastus lateralis muscle were obtained at baseline as well as 1, 4 and 24 h post exercise to investigate gene expression using next generation sequencing analysis. Several important anabolic pathways including PI3K-Akt and MAPK pathways were significantly upregulated at 1 and 4 h post-exercise. Significant between-group differences for both pathways were identified at the 4 h time point demonstrating a more pronounced effect after CP intake. Gene expression related to the mTOR pathway demonstrated a higher visual increase in the CP group compared to PLA by trend, but failed to achieve statistically significant group differences. The current findings revealed a significantly higher upregulation of key anabolic pathways (PI3K-Akt, MAPK) in human skeletal muscle 4 h following an acute resistance training combined with intake of 15 g of specific collagen peptides compared to placebo. Further investigations should examine potential relationships between upregulated gene expression and changes in myofibrillar protein synthesis as well as potential long-term effects on anabolic pathways on the protein level.
Transient Effects of Snow Cover Duration on Primary Growth and Leaf Traits in a Tundra Shrub
Authors: Unterholzner Lucrezia , Prendin Angela Luisa , Dibona Raffaella , Menardi Roberto , Casolo Valentino , Gargiulo Sara , Boscutti Francesco , Carrer Marco
Published: April 2022

With the recent climate warming, tundra ecotones are facing a progressive acceleration of spring snowpack melting and extension of the growing season, with evident consequences to vegetation. Along with summer temperature, winter precipitation has been recently recognised as a crucial factor for tundra shrub growth and physiology. However, gaps of knowledge still exist on long-living plant responses to different snowpack duration, especially on how intra-specific and year-to-year variability together with multiple functional trait adjustments could influence the long-term responses. To fill this gap, we conducted a 3 years snow manipulation experiment above the Alpine treeline on the typical tundra species Juniperus communis, the conifer with the widest distributional range in the north emisphere. We tested shoot elongation, leaf area, stomatal density, leaf dry weight and leaf non-structural carbohydrate content of plants subjected to anticipated, natural and postponed snowpack duration. Anticipated snowpack melting enhanced new shoot elongation and increased stomatal density. However, plants under prolonged snow cover seemed to compensate for the shorter growing period, likely increasing carbon allocation to growth. In fact, these latter showed larger needles and low starch content at the beginning of the growing season. Variability between treatments slightly decreased over time, suggesting a progressive acclimation of juniper to new conditions. In the context of future warming scenarios, our results support the hypothesis of shrub biomass increase within the tundra biome. Yet, the picture is still far from being complete and further research should focus on transient and fading effects of changing conditions in the long term.
Exploring Online and In-Store Purchase Willingness: Associations With the Big Five Personality Traits, Trust, and Need for Touch
Authors: Hermes Anna , Sindermann Cornelia , Montag Christian , Riedl René
Published: April 2022

Nowadays, customers can utilize both online and in-store retail channels. Consequently, it is crucial for retailers to understand the possible drivers of retail channel selection, including customers’ personalities, degrees of trust, and product touch preferences. Unfortunately, current omnichannel research only scarcely addresses the effects of personality, trust, and desire to touch a product before purchasing it on willingness to purchase and how those effects vary between online and in-store shopping. Thus, we conducted an exploratory study. Our analysis of survey data (N = 1,208)—which controls for respondents’ age, gender, and education—reveals that across both the willingness to purchase in-store and online, a higher level of e-vendor trust is a significant, positive predictor. However, we also identify several channel-related differences, including that Trust Propensity, as well as the Big Five traits of Extraversion, Agreeableness, and Conscientiousness are significantly positively related to in-store, but not online, purchase willingness. We also find that Instrumental Need for Touch (defined as goal-motivated touch of a product) is positively related to in-store, but negatively related to online, purchase willingness. Finally, we highlight opportunities for future research and discuss how retail managers might enhance customer experiences in their physical and online stores.
The Science of Lie Detection by Verbal Cues: What Are the Prospects for Its Practical Applicability?
Authors: Brennen Tim , Magnussen Svein
Published: April 2022

There is agreement among researchers that no simple verbal cues to deception detectable by humans have been demonstrated. This paper examines the evidence for the most prominent current methods, critically considers the prevailing research strategy, proposes a taxonomy of lie detection methods and concludes that two common types of approach are unlikely to succeed. An approach to lie detection is advocated that derives both from psychological science and common sense: When an interviewee produces a statement that contradicts either a previous statement by the same person or other information the authorities have, it will in many cases be obvious to interviewer and interviewee that at least one of the statements is a lie and at the very least the credibility of the witness is reduced. The literature on Strategic Use of Evidence shows that features of interviews that foster such revelatory and self-trapping situations have been established to be a free account and the introduction of independent information late and gradually into the proceedings, and tactics based on these characteristics constitute the best current general advice for practitioners. If any other approach 1 day challenges this status quo, it is likely to be highly efficient automated systems.
How to Optimize the Allocation of Anti-epidemic Materials in Public Health Emergencies From the Perspective of Public Economics
Authors: Tang Ziqi , Wang Zhengyi , An Yixuan
Published: April 2022

During the COVID-19 public health crisis, market failures such as shortage of supplies and soaring prices of anti-epidemic materials – with masks as the core – have occurred. In essence, such anti-epidemic materials have the dual nature of necessities with low elasticity of demand and private products with positive externalities. This research explores the understanding of anti-pandemic materials and how different initiatives, and evaluation to increase availability of necessary resources can be effective in curbing a pandemic. Market regulation results in a non-Pareto optimal allocation of resources and the difficulty of exerting the positive externalities of products. However, in China, the market failure of anti-epidemic materials was quickly resolved, due to the institutional advantages of socialism with Chinese characteristics, the social responsibility drive of domestic enterprises, and cultural genes that focus on equity and concern for the disadvantaged. The optimal allocation of anti-epidemic materials gave access to exerting efficiency and fairness effects, positive external effects, and public effects.
Differences in Decision-Making Behavior Between Elite and Amateur Team-Handball Players in a Near-Game Test Situation
Authors: Hinz Matthias , Lehmann Nico , Aye Norman , Melcher Kevin , Tolentino-Castro J. Walter , Wagner Herbert , Taubert Marco
Published: April 2022

Athletic features distinguishing experts from non-experts in team sports are relevant for performance analyses, talent identification and successful training. In this respect, perceptual-cognitive factors like decision making have been proposed to be important predictor of talent but, however, assessing decision making in team sports remains a challenging endeavor. In particular, it is now known that decisions expressed by verbal reports or micro-movements in the laboratory differ from those actually made in on-field situations in play. To address this point, our study compared elite and amateur players’ decision-making behavior in a near-game test environment including sport-specific sensorimotor responses. Team-handball players (N = 44) were asked to respond as quickly as possible to representative, temporally occluded attack sequences in a team-handball specific defense environment on a contact plate system. Specifically, participants had to choose and perform the most appropriate out of four prespecified, defense response actions. The frequency of responses and decision time were used as dependent variables representing decision-making behavior. We found that elite players responded significantly more often with offensive responses (p < 0.05, odds ratios: 2.76–3.00) in left-handed attack sequences. Decision time decreased with increasing visual information, but no expertise effect was found. We suppose that expertise-related knowledge and processing of kinematic information led to distinct decision-making behavior between elite and amateur players, evoked in a domain-specific and near-game test setting. Results also indicate that the quality of a decision might be of higher relevance than the required time to decide. Findings illustrate application opportunities in the context of performance analyses and talent identification processes.
Analysis of Teaching Practices During the COVID-19 Pandemic: Teachers’ Goals and Activities in Virtual Classrooms
Authors: Echeverría María-Puy Pérez , Pozo Juan-Ignacio , Cabellos Beatriz
Published: April 2022

To research teachers’ priorities on what was to be taught and learned during the COVID-19 lockdown, we asked Spanish Primary and Secondary teachers to choose and describe the activity they preferred among those carried out with their students during the pandemic. Our interest was to investigate what really happened in the classrooms, the type of learning favored by the practices (reproductive vs. constructive), and the agreement between the teacher’s goals and their teaching We obtained 272 activities that we analyzed according to the proposed goals, the types of learning worked (verbal, procedural, and attitudinal), and the kind of teaching promoted (content or student-centered). Results showed that most teachers proposed content-centered activities, oriented above all to verbal learning. There were clear differences between the proposed goals, partly student-centered, and what was really taught, essentially content-centered. We obtained two teaching profiles, one reproductive and the other constructive.
School Refusal in Immigrants and Ethnic Minority Groups: A Qualitative Study of Adolescents' and Young Adults' Experiences
Authors: Brault Camille , Thomas Isaiah , Moro Marie Rose , Benoit Laelia
Published: April 2022

Background

School refusal is one cause of school absenteeism along with truancy, and the two can be difficult to distinguish. School absenteeism behaviors among students in transcultural situations (immigrants or children of immigrants) and from ethnic minority groups are subject to misdiagnosis and decreased access to care. To improve the care provided, this exploratory study addresses the experience of adolescents and young adults engaging in school refusal, from immigrant and ethnic minority groups.

Methods

Sixteen participants between the ages of 16 and 20 years old presenting with school refusal were interviewed for this qualitative study. All participants were either immigrants, children of immigrants, or from an ethnic minority group. We conducted a qualitative analysis based on Interpretative Phenomenological Analysis.

Results

Participants experienced school refusal as a loss of identity and as a failure to achieve what was perceived as parental expectations of success, which triggered feelings of worthlessness, shame, and guilt. The loss of a peer group, namely their classmates, as a result of school absenteeism was experienced as a marginalization from the larger society. Although participants denied having personally experienced racism, some of them recalled their parents experiencing racism at school.

Conclusion

School refusal complicates identity construction, autonomy, and integration into society. For adolescents and young adults from immigrant and ethnic minority backgrounds, it also triggers guilt, transgenerational traumatic memories, and the fear of marginalization. In addition to validated therapies for school refusal, sociological, intersectional, and cross-cultural tools would be a valuable addition to treatment.
Emotional Dysregulation and Adaptive Functioning in Preschoolers With Autism Spectrum Disorder or Other Neurodevelopmental Disorders
Authors: Davico Chiara , Marcotulli Daniele , Cudia Valentina Francesca , Arletti Luca , Ghiggia Ada , Svevi Barbara , Faraoni Chiara , Amianto Federico , Ricci Federica , Vitiello Benedetto
Published: April 2022

Aim

Emotional dysregulation (ED), defined by deficits in the ability to monitor and modulate the valence, intensity, and expression of emotions, is typically expressed with irritability, tantrums, mood fluctuations, and self-harm in young children with autism spectrum disorder (ASD). Although ED does not represent a diagnostic feature of ASD, its manifestations are an important contributor to functional impairment and clinical referral. This study aims to examine the relationship between ED and adaptive functioning in preschoolers clinically referred for ASD or other neurodevelopmental disorders.

Methods

A sample of 100 children (74% males, mean age 39.4 ± 12.3 months), consecutively referred to a university clinic for neurodevelopmental disorders, received clinical assessments of psychopathology with the CBCL and the Autism Diagnostic Interview-Revised, of ED- with the CBCL-Attention, Anxious/Depressed, and Aggression index (CBCL-AAA), of autism symptom severity with the ADOS-2 Calibrated Severity Score (ADOS-CSS), and of global developmental/cognitive delay (GDD) with the WPPSI-IV or other age-appropriate standardized scales. Adaptive functioning was measured with the ABAS-II. Sixty-five children met DSM-5 criteria for ASD. Multivariate regression models were applied to evaluate the relative contribution of ED, ASD severity and GDD to the ABAS-II general (GAC), conceptual (CAD), social (SAD), and practical (PAD) adaptive functioning domains.

Results

Overall (n = 100), lower adaptive functioning was associated with higher CBCL-AAA (p = 0.003), higher ADOS-CSS (p < 0.001), and presence of GDD (p = 0.023). In the ASD group (n = 65), worse CAD was predicted by GDD (p = 0.016), and worse SAD and PAD by higher ADOS-CSS (p = 0.032) and ED (p = 0.002). No sex differences were detected in the study variables.

Conclusion

Together with the severity of global developmental delay and of autism symptoms, ED is a significant contributor to impairment in adaptive functioning among young children with a neurodevelopmental disorder and, in particular, with ASD. ED could represent a specific target for early interventions aimed at enhancing adaptive functioning in early childhood.
Ambulophobia as a Specific Phobia—Defining the Problem Among Patients of Long-Term Care Facilities in Poland
Authors: Górski Michał , Buczkowska Marta , Krzywkowska Karolina , Całyniuk Beata , Górska Karolina , Buczkowski Krzysztof , Fojcik Joanna , Grajek Mateusz , Polaniak Renata
Published: April 2022

Background

Ambulophobia is a type of specific phobia that involves a fear of walking. This phobia mainly affects older people, who prefer not to leave their bed or home to avoid walking on uneven surfaces and reduce the risk of falling. The problem seems to be very important in terms of public health and the organization of long-term care, as Poland has one of the highest rates of elderly population growth.

Objectives

The aim of the study was to determine the prevalence of ambulophobia among patients of long-term care facilities in Poland and to identify factors increasing the risk of this specific phobia in the study group.

Material and Methods

The study was conducted between January and July 2021. Data collected from 379 patients of 16 long-term care facilities located in Poland were analyzed. The study used the diagnostic criteria for specific phobias according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, and standardized questionnaires such as MMSE, GDS-16, DOS and ADL. The χ2 test was used to test the significance of differences (p = 0.05).

Results

The prevalence of ambulophobia in the study group was 30.1%. Ambulophobia significantly more often concerned the female sex (37.7%) and people over 70 years of age (42,1%). Factors such as depression, Parkinson's disease, orthostatic hypotonia, a history of falling or being a witness to another person falling, and disability of at least a moderate degree increased the likelihood of ambulophobia.

Conclusions

Based on the obtained results, it was found that the protective factors in the development of ambulophobia are male sex, younger age, high independence, fewer drugs used per day and no previous falls or seeing another person fall.
Cumulative Family Risk and Internet Gaming Disorder Among Adolescents: A Serial Mediating Model of Personal Growth Initiative and Gratitude
Authors: Gan Xiong , Xiang Guo-Xing , Li Hao , Wang Shao-Hua , Jin Xin , Zhu Cong-Shu
Published: April 2022

In the digital era, playing internet games enriches the entertainment forms for young generations. At the same time, it also raises some social issues, and internet gaming disorder (IGD) is one of them. Abundant studies demonstrate that IGD is harmful to individual physiological and psychological health. Therefore, it is necessary to figure out the reasons and mechanisms behind this phenomenon. Based on the ecological systems theory, the present study investigated the cumulative effect of family risks on adolescent IGD and the serial mediating effects of personal growth initiative (PGI) and gratitude in a chain mediation model. Using random cluster sampling, a sample of 600 Chinese adolescents was recruited to complete the questionnaire. Results of regression analysis suggested that cumulative family risks could positively predict IGD among adolescents. Moreover, PGI and gratitude mediated the relationship between cumulative family risk and IGD, separately, and sequentially. These findings may provide some guidance for the prevention and intervention to prevent or reduce IGD in adolescents.
The Association Between Maternal Shaking Behavior and Inappropriate Infant Parenting: The Japan Environment and Children's Study
Authors: Sakakihara Aya , Masumoto Toshio , Kurozawa Youichi
Published: April 2022

Background

Although many studies have identified risk factors for maternal shaking behavior, it is unknown whether mothers who have shaken their infants repeat shaking behavior or show other inappropriate parenting behaviors. Using data from the Japan Environment and Children's Study (JECS) birth cohort study, we investigated the associations between continuous shaking behavior and the associations between shaking behavior and other inappropriate parenting behaviors.

Methods

JECS data starting from 2011 were used. Logistic regression was used to perform a cross-sectional analysis. The explanatory variable was shaking behavior and the dependent variables were leaving the infant home alone and hitting the infant (both at 1 month postpartum), and non-vaccination and infant burns (both at 6 months postpartum). A longitudinal analysis using logistic regression was also performed; here the explanatory variable was shaking behavior at 1 month postpartum and the dependent variables were shaking behavior, non-vaccination of the infant, and infant burns (all at 6 months postpartum).

Results

In this study, 16.8% and 1.2% of mothers reported shaking behavior at 1 month and 6 months postpartum, respectively. Mothers who shook their infants at 1 month postpartum were approximately five times more likely to shake them at 6 months postpartum compared with mothers who had not shown previous shaking behavior (OR = 4.92, 95% CI [4.22, 5.73], p < 0.001). In Cross-sectional study, there were associations between shaking behavior and inappropriate parenting behavior such as hitting the infant and infant burns.

Conclusion

The findings suggest that mothers who report early shaking behavior tend to subsequently repeat this behavior, and that shaking behavior may be associated with other inappropriate parenting behaviors.
Analysis of Urban Built Environment Impacts on Outdoor Physical Activities—A Case Study in China
Authors: Li Bo , Liu Qiuhong , Wang Tong , He He , Peng You , Feng Tao
Published: April 2022

Outdoor physical activities can promote public health and they are largely influenced by the built environment in different urban settings. Understanding the association between outdoor physical activities and the built environment is important for promoting a high quality of life. Existing studies typically focus on one type of outdoor activity using interview-based small samples and are often lack of systematic understanding of the activities' intensity and frequency. In this study, we intend to gain deeper insight into how the built environment influences physical activities using the data extracted from individual's wearables and other open data sources for integrated analysis. Multi-linear regression with logarithm transformation is applied to perform the analysis using the data from Changsha, China. We found that built environment impacts on outdoor physical activities in Changsha are not always consistent with similar studies' results in other cities. The most effective measures to promote outdoor physical activities are the provision of good arterial and secondary road networks, community parks, among others in Changsha. The results shed light on future urban planning practices in terms of promoting public health.
Smartphone Use, Technology Affordance for Healthcare and Elders' Life Satisfaction
Authors: Li Geling , Jin Chenfei , Zhao Bin , Wu Bao
Published: April 2022

Previous studies have examined how smartphones influence the life satisfaction of the elderly, but the existence of conflicting conclusions suggests the existence of a “black box”. In this study, using a survey from 941 elders, we examine whether smartphone use can improve life satisfaction of the elders by inducing emotional affordance offered by social networking Apps and functional affordance offered by healthcare system Apps. It is found that both emotional affordance and functional affordance acted as intermediating variables between the use of smartphone and elders' life satisfaction. In addition, it is founded that living arrangement with adult children moderates the positive impact of smartphone use on functional affordance, but there was no such moderating effect on emotional affordance. This study offers insights about how digital healthcare innovation will be applied to increase well-being of elders by applying framework of selective optimization with compensation.
Neuroticism Trait and Mental Health Among Chinese Firefighters: The Moderating Role of Perceived Organizational Support and the Mediating Role of Burnout—A Path Analysis
Authors: Tao Yanqiang , Ma Zijuan , Hou Wenxin , Zhu Yuanyuan , Zhang Liang , Li Chunbo , Shi Congying
Published: April 2022

Perceived organizational support (POS) in the relationship between neuroticism and job burnout among firefighters received little attention in China. A sampling of 716 firefighters in China, we drew on perceived organization support theory and the notion of support as a buffer in job burnout, examining moderating effects of POS on the relationship between neuroticism and three components of burnout (emotional exhaustion, depersonalization and reduced personal accomplishment). Also, this study explored the mediating effect of burnout on the relationship between neuroticism and mental health (i.e., anxiety and depression). We found that two components (depersonalization and emotional exhaustion) of burnout have significantly mediated the relationship between neuroticism and anxiety and depression. At the same time, POS reinforced the relationship between neuroticism and depersonalization and emotional exhaustion. Therefore, organizations can take our analysis into account when taking actions to improve firefighters' mental health. The implications of these findings were discussed.
A Model of Unified Perception and Cognition
Authors: Wang Pei , Hahm Christian , Hammer Patrick
Published: April 2022

This article discusses an approach to add perception functionality to a general-purpose intelligent system, NARS. Differently from other AI approaches toward perception, our design is based on the following major opinions: (1) Perception primarily depends on the perceiver, and subjective experience is only partially and gradually transformed into objective (intersubjective) descriptions of the environment; (2) Perception is basically a process initiated by the perceiver itself to achieve its goals, and passive receiving of signals only plays a supplementary role; (3) Perception is fundamentally unified with cognition, and the difference between them is mostly quantitative, not qualitative. The directly relevant aspects of NARS are described to show the implications of these opinions in system design, and they are compared with the other approaches. Based on the research results of cognitive science, it is argued that the Narsian approach better fits the need of perception in Artificial General Intelligence (AGI).
From Start-to-Finish: A Partnership With Advanced Practice Providers in Tele-Consultation Within Pediatric Urology
Authors: Crigger Chad , Sholklapper Tamir , Mitchell Katharina , Eckert Kristie , Zupper Shirley , Bartlett Megan , Ost Michael C. , Al-Omar Osama
Published: April 2022

Background

Telemedicine is now commonplace and an accepted modality for delivering health care due to the coronavirus pandemic. It has proven useful in increasing access to traditionally limited subspecialties and bridged the gap of local regional geographic restraints. We report a follow up of our experience building tele-consultation capacity for pediatric urology in a resource constrained area. Specifically, we hypothesize that hybrid tele-consultation is a safe modality for postoperative evaluation. A secondary goal of this study is to evaluate perceived barriers to implementing this practice from the perspective of advanced practice providers (APPs).

Methods

After obtaining IRB approval (IRB# 1910741113), patients were prospectively recruited for tele-consultation encounters with a tertiary academic center between August 2018 and March 2020 (pre-dating the coronavirus pandemic). Advanced practice providers received additional training in physical diagnosis and examination prior to returning to satellite clinics in their local communities and facilitating tele-consultation with an academic pediatric urologist. Postoperative outcomes were analyzed out to eight weeks and any peri- and postoperative complications were assessed using the Clavien-Dindo classification system. Finally, anonymous surveys were administered to the APPs at the conclusion of the recruitment period to assess their satisfaction with telemedicine clinics and perceived barriers to implementation.

Results

92 telemedicine encounters took place between August 2018 and March 2020. The most common reasons for presentation were undescended testis (UDT) (n=15), urinary tract infection (n=13) and enuresis (n=13). The most common surgical case booked by the APPs in the satellite clinic was orchiopexy (n=10). Mean distance travel saved was 299.8 miles. In 23 patients who were schedule surgery, only two patients (8.7%) had an initial diagnosis that differed with their APP pre-operative diagnosis. Of the 22 patients who underwent surgery, all elected telemedicine visits for postoperative evaluation. No patient experienced complications. Initial consultations averaged 14 minutes (range 9 to 20 minutes), while mean duration of postoperative evaluations was 9 minutes (range 6 to 13 minutes). With regards to surveys, APPs reported an overall positive experience with tele-consultation (4.5/5, n=7) and all planned on incorporating it into their future practice (4.9/5, n =7).

Conclusion

A hybrid tele-consultation video conferencing clinic with heavy reliance on APPs is a safe, reliable and economical way to address pediatric subspecialty surgical needs in the rural setting. With proper training and exposure, APPs can safely perform preoperative assessments and correctly refer patients for surgical intervention, adding efficiency to the surgical subspecialty workflow.