bluuebunny/crossref_metadata_2025 huggingface dataset:
A survey of patients’ views from eight European countries of interpretive support from Specialists in Laboratory Medicine
Authors: Watson Ian D. , Oosterhuis Wytze P. , Jorgensen Per E. , Dikmen Z. Gunnur , Siodmiak Joanna , Jovicic Snezana , Aakre Kristin M. , Palicka Vladimir , Kutt Marge
Published: May 2017

Background:

There is increasing interest in direct patient engagement including receiving their laboratory medicine results. We previously established an appetite for Specialists in Laboratory Medicine to support patients in understanding results. The aim of this study was to establish whether patients agreed with such an approach, determined through surveying views in eight European countries.

Methods:

A standardized five-question survey was administered across eight European countries to a total of 1084 individuals attending medical outpatient clinics, with 100 patients each in Poland, Serbia, Netherlands, Turkey and Czech Republic, 101 in Estonia, 116 in Denmark and 367 in Norway. The responses across countries were compared using the chi-square test (p<0.05).

Results:

Patients wanting their results ranged from 50% to 94% (mean 65%) of those responding positively, a mean of 72% wanted additional information with their results; direct receipt was preferred over referral to a website. Specialists in Laboratory Medicine providing such information were acceptable to a mean of 62% of those respondents wishing their results; in countries where payment was possible, there was little interest in making additional payment for such a service.

Conclusions:

A clear proportion of patients are interested in receiving their laboratory medicine results, the majority with explanatory notes; a role for Specialists in Laboratory Medicine is acceptable and raises the potential for direct engagement by such specialists with patients offering a new paradigm for the provision of laboratory medicine activities.
Mean curvature flow of noncompact hypersurfaces with Type-II curvature blow-up
Authors: Isenberg James , Wu Haotian
Published: May 2017

We study the phenomenon of Type-II curvature blow-up in mean curvature flows of rotationally symmetric noncompact embedded hypersurfaces. Using analytic techniques based on formal matched asymptotics and the construction of upper and lower barrier solutions enveloping formal solutions with prescribed behavior, we show that for each initial hypersurface considered, a mean curvature flow solution exhibits the following behavior near the “vanishing” time T: (1) The highest curvature concentrates at the tip of the hypersurface (an umbilic point), and for each choice of the parameter

γ
>

1
2

{\gamma>\frac{1}{2}}

, there is a solution with the highest curvature blowing up at the rate

(

T
-
t

)

-

(

γ
+

1
2

)

{(T-t)^{{-(\gamma+\frac{1}{2})}}}

. (2) In a neighborhood of the tip, the solution converges to a translating soliton which is a higher-dimensional analogue of the “Grim Reaper” solution for the curve-shortening flow. (3) Away from the tip, the flow surface approaches a collapsing cylinder at a characteristic rate dependent on the parameter γ.
On two questions concerning representations distinguished by the Galois involution
Authors: Gurevich Maxim , Ma Jia-Jun , Mitra Arnab
Published: May 2017

Let

E
/
F

{E/F}

be a quadratic extension of non-archimedean local fields of characteristic 0.
In this paper, we investigate two approaches which attempt to describe the irreducible smooth representations of

GL
n

⁢

(
E
)

{\mathrm{GL}_{n}(E)}

that are distinguished by its subgroup

GL
n

⁢

(
F
)

{\mathrm{GL}_{n}(F)}

.
One relates this class to representations which come as base change lifts from a quasi-split unitary group over F, while another deals with a certain symmetry condition.
By characterizing the union of images of the base change maps, we show that these two approaches are closely related.
Using this observation, we are able to prove a statement relating base change and distinction for ladder representations.
We then produce a wide family of examples in which the symmetry condition does not impose

GL
n

⁢

(
F
)

{\mathrm{GL}_{n}(F)}

-distinction, and thus exhibit the limitations of these two approaches.
Regularity of complex geodesics and (non-)Gromov hyperbolicity of convex tube domains
Authors: Pflug Peter , Zwonek Włodzimierz
Published: May 2017

We deliver examples of non-Gromov hyperbolic tube domains with convex bases (equipped with the Kobayashi distance). This is shown by providing a criterion on non-Gromov hyperbolicity of (non-smooth) domains. The results show the similarity of geometry of the bases of non-Gromov hyperbolic tube domains with the geometry of non-Gromov hyperbolic convex domains. A connection between the Hilbert metric of a convex domain Ω in

ℝ
n

{\mathbb{R}^{n}}

with the Kobayashi distance of the tube domain over the domain Ω is also shown. Moreover, continuity properties up to the boundary of complex geodesics in tube domains with a smooth convex bounded base are also studied in detail.
A two-dimensional backward heat problem with statistical discrete data
Authors: Minh Nguyen Dang , To Duc Khanh , Tuan Nguyen Huy , Trong Dang Duc
Published: May 2017

We focus on the nonhomogeneous backward heat problem of finding the initial temperature

θ
=

θ
⁢

(
x
,
y
)

=

u
⁢

(
x
,
y
,
0
)

{\theta=\theta(x,y)=u(x,y,0)}

such that

{

u
t

-

a
⁢

(
t
)

⁢

(

u

x
⁢
x

+

u

y
⁢
y

)

=

f
⁢

(
x
,
y
,
t
)

,

(
x
,
y
,
t
)

∈

Ω
×

(
0
,
T
)

,

u
⁢

(
x
,
y
,
t
)

=
0

,

(
x
,
y
)

∈

∂
⁡
Ω

×

(
0
,
T
)

,

u
⁢

(
x
,
y
,
T
)

=

h
⁢

(
x
,
y
)

,

(
x
,
y
)

∈

Ω
¯

,

\left\{\begin{aligned} \displaystyle u_{t}-a(t)(u_{xx}+u_{yy})&\displaystyle=f%
(x,y,t),&\hskip 10.0pt(x,y,t)&\displaystyle\in\Omega\times(0,T),\\
\displaystyle u(x,y,t)&\displaystyle=0,&\hskip 10.0pt(x,y)&\displaystyle\in%
\partial\Omega\times(0,T),\\
\displaystyle u(x,y,T)&\displaystyle=h(x,y),&\hskip 10.0pt(x,y)&\displaystyle%
\in\overline{\Omega},\end{aligned}\right.\vspace*{-0.5mm}

where

Ω
=

(
0
,
π
)

×

(
0
,
π
)

{\Omega=(0,\pi)\times(0,\pi)}

. In the problem, the source

f
=

f
⁢

(
x
,
y
,
t
)

{f=f(x,y,t)}

and the final data

h
=

h
⁢

(
x
,
y
)

{h=h(x,y)}

are determined through random noise data

g

i
⁢
j

⁢

(
t
)

{g_{ij}(t)}

and

d

i
⁢
j

{d_{ij}}

satisfying the regression models

g

i
⁢
j

⁢

(
t
)

=

f
⁢

(

X
i

,

Y
j

,
t
)

+

ϑ
⁢

ξ

i
⁢
j

⁢

(
t
)

,

\displaystyle g_{ij}(t)=f(X_{i},Y_{j},t)+\vartheta\xi_{ij}(t),

d

i
⁢
j

=

h
⁢

(

X
i

,

Y
j

)

+

σ

i
⁢
j

⁢

ε

i
⁢
j

,

\displaystyle d_{ij}=h(X_{i},Y_{j})+\sigma_{ij}\varepsilon_{ij},

where

(

X
i

,

Y
j

)

{(X_{i},Y_{j})}

are grid points of Ω. The problem is severely ill-posed.
To regularize the instable solution of the problem, we use the trigonometric least squares method in nonparametric regression associated with the projection method. In addition, convergence rate is also investigated numerically.
Identification of a kernel in an evolutionary integral equation occurring in subdiffusion
Authors: Janno Jaan , Kasemets Kairi
Published: May 2017

An inverse problem to determine a kernel in an evolutionary integral equation occurring in modeling of subdiffusion is considered.
The existence, uniqueness and stability of a solution of the inverse problem are proved in an abstract setting.
The results are global in time.
Depth dependent resolution in Electrical Impedance Tomography
Authors: Alessandrini Giovanni , Scapin Andrea
Published: May 2017

We consider the two-dimensional version of Calderòn’s problem. When the Dirichlet-to-Neumann map is assumed to be known up to an error level

ε
0

{\varepsilon_{0}}

, we investigate how the resolution in the determination of the unknown conductivity deteriorates the farther one goes from the boundary. We provide explicit formulas for the resolution, which apply to conductivities which are perturbations, concentrated near an interior point q, of the homogeneous conductivity.
Plasma free fatty acids in hyperemesis gravidarum pregnancy
Authors: Ulubay Mustafa , Ozturk Mustafa , Ozturk Ozlem , Keskin Ugur , Fidan Ulas , Sertoglu Erdim , Aydin Hakan , Yilmaz Ali , Cemal Yenen Mufit
Published: May 2017

We evaluated the free fatty acids differences in plasma between hyperemesis gravidarum(HG) and healthy pregnant in first trimester pregnancy.

Objective

We aimed to compare the plasma levels of DHA, AA and EPA, between HG patients and healthy pregnant women

Design

Fifty-two pregnants were involved in the study. Twenty-six pregnants of them were HG as study group, and twenty-six pregnants were enrolled as healthy pregnant women at the similar gestational age. The saturated fatty acids C14, C15, C16, C18, C20, C22, and C24; the omega-3 fatty acids eicosapentaenoic acid, (EPA) and docosahexaenoic acid, (DHA); the omega-6 fatty acids linoleic acid, arachidonic acid (AA), and homo-gamma-linolenic acid; and the omega-9 fatty acids oleic acid, erucic acid, and nervonic acid were analysed by gas chromatography.

Results

Statistically differences was not seen between the groups with maternal age, gestational age, or plasma levels of EPA, DHA, and AA. Statistically significant difference was seen between the groups with plasma levels of C20 and C22(p<0.05). C20 was declined but C22 was rised in the HG patients.

Conclusion

EPA, DHA, or AA, which related to placental and fetal neural development are not changing from Hyperemesis gravidarum.
Brain strokes related to aortic aneurysma – the analysis of three cases
Authors: Pastuszak Żanna , Stępień Adam , Kordowska Joanna , Rolewska Agnieszka , Galbarczyk Dariusz
Published: May 2017

Brain stroke connected with aortic blood flow disturbances is a rare disease and its incidence is difficult to assume. Nevertheless, 10-50% of patients with aortic dissection may not experience any pain. In case of 18-30% patients with aortic dissection neurological signs are first disease presentation and among them ischemic stroke is the most common. The most popular aortic dissection classification is with use of Stanford system. Type A involves the ascending aorta and type B is occurring distal to the subclavian artery. Aortic dissection risk factors include hypertension, cystic medionecrosis, bicuspid aortic valve and Marfan’s or Ehlers-Danlos syndrome.
Influence of the polyacrylonitrile proportion on the fabricated UF blend membranes’ performance for humic acid removal
Authors: Abdallah Heba , Jamil Tarek S. , Shaban A.M. , Mansor Eman S. , Souaya Eglal R.
Published: May 2017

Asymmetric blend membranes of polyethersulfone (PES)/polyacrylonitrile (PAN) were prepared and developed for ultrafiltration applications. The membranes were prepared by dissolving two polymers in N-methyl-2-pyrrolidone (NMP) as a solvent with diethylene glycol (DEG) and polyvinylpyrrolidone (PVP) as non-solvent and pore former, respectively. The produced membranes were characterized by scanning electron microscopy (SEM) and fourier transform infrared (FTIR) spectroscopy, and the hydrophilicity of membranes was tested by contact angle measurements. The performance of prepared membranes was carried out by an ultrafiltration testing unit, where the efficiency of membranes was determined according to the humic acid separation and treated water permeate flux. The results indicated that using 1 wt.% of PAN in polymer mixture provided a blending membrane with high mechanical properties and high performance; the humic acid rejection reached 92.47% with treated water permeate flux 70 l/m2·h at feed pressure 6 bar.
Europeanization and minority policies in post-conflict Kosovo. Genuine inclusion or window dressing?
Authors: Potter Michael
Published: May 2017

This paper examines the position of minorities in Kosovo in the light of Kosovo’s potential candidacy as a member state of the European Union (EU). The paper contends that although the international community has constructed a comprehensive suite of protections and guarantees for minorities, nation-building by internal actors in Kosovo has followed an exclusively ethnocentric dominant narrative, running counter to the state-building project, which promotes a multiethnic Kosovo. The paper considers this dichotomy in the context of Kosovo’s Europeanization. It is concluded that the conditionality principle is not sufficiently defined or measurable in order to set criteria relating to the inclusion or exclusion of minorities in Kosovo to significantly influence decisions on EU membership.
Security sector reform in Bosnia and Herzegovina. A case study of the Europeanization of the Western Balkans
Authors: Kudlenko Anastasiia
Published: May 2017

Security sector reform (SSR) has become an important part of the EU’s efforts to transform the Western Balkans from a conflict-ridden area into a stable and democratic part of Europe. This paper studies SSR in Bosnia and Herzegovina (BiH) as an illustration of the multifaceted and complex Europeanization policies employed by the EU in the region. It does not present a study of the European Security and Defence Policy (ESDP) missions, as there is already a wealth of material available on this subject, but offers instead a broader examination of changes in two sectors of BiH’s security system with the aim of improving understanding of the EU’s impact on the domestic environments of candidate states. Its main argument is that the EU used police and intelligence reforms in Bosnia, both of which were part and parcel of the SSR efforts in the country, as state-building tools. But because domestic competence in Bosnia was lacking and the EU was rather inexperienced in implementing SSR, the reforms have had a mixed record of success and reveal the limitations of the region’s Europeanization.
Mirroring transitional justice. Construction and impact of European Union ICTY-conditionality
Authors: Wentholt Niké
Published: May 2017

The European Union (EU) developed a state-building strategy for the aspiring member states in the Western Balkans. Demanding full cooperation with the International Criminal Tribunal for the former Yugoslavia (ICTY), the EU made transitional justice part of the accession demands. Scholars have recently criticized the EU’s limited focus on retributive justice as opposed to restorative justice. This paper goes beyond such impact-orientated analyses by asking why the EU engaged with retributive transitional justice in the first place. The EU constructed ICTY-conditionality by mirroring its own post-Second World War experiences to the envisioned post-conflict trajectory of the Western Balkans. The EU therefore expected the court to contribute to reconciliation, democratization and the rule of law. Using Serbia as a case study, this article examines the conditionality’s context, specificities and discursive claims. Finally, it relates these findings to the agenda of a promising regional initiative prioritizing restorative justice (RECOM) and sheds new light on the impact of ICTY-conditionality on transitional justice in the Western Balkans.
Counting for what purpose? The paradox of including ethnic and cultural questions in the censuses of Croatia, Bosnia-Herzegovina, and Macedonia
Authors: Hoh Anna-Lena
Published: May 2017

The Western Balkan countries are on the long road to European Union (EU) membership. One aspect of the accession process is the requirement for a population census, which falls under the acquis communautaire chapter covering the statistics needed. In the Western Balkans, censuses have included questions on ethnicity, language, and religion. The collection of data on ethnic and cultural characteristics raises an unresolved paradox: such questions are highly sensitive, but, in order to be able to protect minorities through, for example, antidiscrimination laws, the authorities need to know that these minorities exist. This article uses the additional coverage model mixed methods approach to illustrate the effects of including ethnic and cultural characteristics in the census questionnaires in Croatia, Bosnia-Herzegovina, and Macedonia, where population numbers are used to determine group rights and/or proportional representation. The article argues that, although taking a census forms part of the EU conditions, it is not possible to speak of Europeanization in this area, since there is no coherent European approach on how to collect ethnic and cultural data. However, as what appears in the censuses is linked to rights, the census processes can be highly politicized, and this is being overlooked in the general process of Europeanization.
Talk the talk, or walk the walk? Changing narratives in Europeanization research
Authors: Agarin Timofey , Yilmaz Gözde
Published: May 2017

Over the past two decades, there has been a growing interest in Europeanization, both within and beyond the European Union (EU). The impact of Eastern enlargement in 2004 on candidate and neighbourhood countries has attracted scholarly attention, and a consensus currently exists on the success of the EU’s transformative power through the employment of a conditionality mechanism. However, the limits of EU conditionality upon candidate countries and neighbourhood Europeanization, in addition to the problems experienced by the EU itself, have brought into question whether the end of Europeanization research is in sight. Considering this, we critically evaluate the issues discussed in the scholarship on Europeanization and review several points of interest in relation to EU candidate countries in the Western Balkans as well as Turkey.
Effect of Short-term Coenzyme Q10 Supplementation and Precooling on Serum Endogenous Antioxidant Enzymes of Elite Swimmers
Authors: Emami Ali , Tofighi Asghar , Asri-Rezaei Siamak , Bazargani-Gilani Behnaz
Published: May 2017

Emami, A, Tofighi, A, Asri-Rezaei, S, and Bazargani-Gilani, B. Effect of short-term coenzyme Q10 supplementation and precooling on serum endogenous antioxidant enzymes of elite swimmers. J Strength Cond Res 32(5): 1431–1439, 2018—This study aimed to investigate the effect of the use of a 2-week precooling strategy and supplementation coenzyme Q10 (CoQ10) on superoxide dismutase (SOD), catalase (CAT), and serum glutathione peroxidase (GPx) in elite, adolescent swimmers during heavy and regular trainings and recording of freestyle swimming. Thirty-six healthy males (mean ± SD; age: 17.5 ± 1.1 years, body fat content: 14.55 ± 1.75%) were randomly selected and divided into 4 groups of CoQ10 (300 mg·d−1), precooling (immersion in the water at 18 ± 0.5° C), supplementation with precooling, and control, each with 9 participants. During an 18-session protocol in the morning and evening, participants attended speed and endurance trainings for 5 km every session. A 3-stage blood sampling was conducted before the first recording and before and after the second recording in 800, 200, and 50 m. Repeated measurement and the Bonferroni correction were used for the statistical analyses of the data (α = 0.05). According to the results, there was no significant difference between the mean serum level of SOD, CAT, and GPx in the groups at the first stage of blood sampling (p > 0.05). At the third stage, a significant difference was observed among all groups (p < 0.05). At the second stage, precooling and control groups show a significant increase compared with the supplementation and supplementation with precooling groups (p < 0.05). As an antioxidant essential for adenosine triphosphate synthesis, CoQ10 supplementation prevented adverse changes of antioxidant enzymes during heavy trainings and swimming recording and decreased the serum level, while precooling individually increased serum level of antioxidant enzymes by itself.
Short-Term Heat Acclimation and Precooling, Independently and Combined, Improve 5-km Time Trial Performance in the Heat
Authors: James Carl A. , Richardson Alan J. , Watt Peter W. , Willmott Ashley G.B. , Gibson Oliver R. , Maxwell Neil S.
Published: May 2017

James, CA, Richardson, AJ, Watt, PW, Willmott, AGB, Gibson, OR, and Maxwell, NS. Short-term heat acclimation and precooling, independently and combined, improve 5-km time trial performance in the heat. J Strength Cond Res 32(5): 1366–1375, 2018—Following heat acclimation (HA), endurance running performance remains impaired in hot vs. temperate conditions. Combining HA with precooling (PC) demonstrates no additive benefit in intermittent sprint, or continuous cycling exercise protocols, during which heat strain may be less severe compared to endurance running. This study investigated the effect of short-term HA (STHA) combined with mixed methods PC, on endurance running performance and directly compared PC and HA. Nine amateur trained runners completed 5-km treadmill time trials (TTs) in the heat (32° C, 60% relative humidity) under 4 conditions; no intervention (CON), PC, short-term HA (5 days—HA) and STHA with PC (HA + PC). Mean (±SD) performance times were; CON 1,476 (173) seconds, PC 1,421 (146) seconds, HA 1,378 (116) seconds and HA + PC 1,373 (121) seconds. This equated to the following improvements versus CON; PC −3.7%, HA −6.6% and HA + PC −7.0%. Statistical differences were only observed between HA and CON (p = 0.004, d = 0.68, 95% CI [−0.27 to 1.63]) however, similar effect sizes were observed for HA + PC vs. CON (d = 0.70, 95% CI [−0.25 to 1.65]), with smaller effects between PC vs. CON (d = 0.34, 95% CI [−0.59 to 1.27]), HA vs. PC (d = 0.33, 95% CI [−0.60 to 1.26]) and HA + PC vs. PC (d = 0.36, 95% CI [−0.57 to 1.29]). Pilot testing revealed a TT typical error of 16 seconds (1.2%). Precooling offered no further benefit to performance in the acclimated individual, despite modest alleviation of physiological strain. Maintenance of running speed in HA + PC, despite reduced physiological strain, may indicate an inappropriate pacing strategy therefore, further familiarization is recommended to optimize a combined strategy. Finally, these data indicate HA, achieved through cycle training, yields a larger ergogenic effect than PC on 5-km running performance in the heat, although PC remains beneficial when HA is not possible.
Acute Effect of Upper and Lower Body Postactivation Exercises on Shot Put Performance
Authors: Kontou Eleni I. , Berberidou Fani T. , Pilianidis Theophilos C. , Mantzouranis Nikolaos I. , Methenitis Spyridon K.
Published: May 2017

Kontou, EI, Berberidou, FT, Pilianidis, TC, Mantzouranis, NI, and Methenitis, SK. Acute effect of upper and lower body postactivation exercises on shot put performance. J Strength Cond Res 32(4): 970–982, 2018—The purpose of this study was to investigate the effect of different types of upper and lower' extremities exercises on acute increase of shot put performance, in moderate experienced throwers. Eight (n = 8) males and 9 (n = 9) female throwers participated in this study. Their bench press and squat maximum strength were measured while their shot put performance from power position was evaluated before and after 4 interventions: (a) plyometric push-ups (Plyo), (b) 6 s isometric push-ups (Iso), (c) 3 countermovement jumps (CMJs) and (d) 10 reps. of skipping (Skip). Interventions were performed in counterbalanced order with a 48-hour interval. Significant increase (p < 0.05) of shot put performances was observed after Plyo, Iso, and CMJ (range: 2.30 ± 1.82%–5.72 ± 4.32%). In addition, Iso induced the highest increase while Skip did not induce any improvement of throwing performance. The highest increases were recorded in men's performance after CMJ (5.72 ± 4.32%) while in women's performance after Iso (3.59 ± 2.7%). Javelin and discus throwers increase higher their performance after CMJs while shot putters after Iso. Significant correlations were found between training experience, maximum/relative strength, shot put performance and increase of throwing performance (%) after the interventions (r: 0.519–0.991, p < 0.05). Percentage increase of performance between Iso and Plyo have negative correlations (r: −0.569, p < 0.05) in contrast of those between Skip and CMJ (r: 0.710, p < 0.05). These results suggest that upper or lower body postactivation interventions may acutely increase the throwing performance. However, experience and strength are significant determinant of this increase.
Effects of Two Combined Exercise Designs Associated With High-Fat Meal Consumption on Postprandial Lipemia, Insulinemia, and Oxidative Stress
Authors: Farinha Juliano B. , Macedo Carlos Ernani O. , Rodrigues-Krause Josianne , Krüger Renata L. , Boeno Francesco P. , Macedo Rodrigo C.O. , Queiroz Jéssica N. , Teixeira Bruno C. , Reischak-Oliveira Alvaro
Published: May 2017

Farinha, JB, Macedo, CEO, Rodrigues-Krause, J, Krüger, RL, Boeno, FP, Macedo, RCO, Queiroz, JN, Teixeira, BC, and Reischak-Oliveira, A. Effects of two combined exercise designs associated with high-fat meal consumption on postprandial lipemia, insulinemia, and oxidative stress. J Strength Cond Res 32(5): 1422–1430, 2018—Impaired postprandial lipemia (PPL) response after the consumption of a high-fat meal (HFM) is linked to diabetes, oxidative stress, and cardiovascular events. The aim of this study was to investigate lipid and glucose metabolism and oxidative stress responses of 2 different combined exercise designs associated with HFM consumption. Eleven healthy and physically active men (27.36 ± 5.04 years) participated in this study. After the pretrial visits, participants were randomly assigned to perform 2-day trials in 3 different conditions (interspaced by at least 1 week): resting (REST), circuit combined exercise (CIRC), or traditional combined exercise (COMB), on the evening of day 1. On the morning of day 2, an HFM was provided and blood samples were obtained before and after 1, 3, and 5 hours of HFM consumption. No differences were found with respect to glucose, thiobarbituric acid–reactive substances, or total thiol levels in between time points or conditions. One-way analysis of variance demonstrated a difference between REST and CIRC (p = 0.029; reduction of 35.29%) and between REST and COMB (p = 0.041; reduction of 33.41%) conditions with incremental area under the curve (iAUC) for triacylglycerol levels. A difference between REST and CIRC (p = 0.03; reduction of 34.22%) conditions in terms of iAUC for insulin was also found. Both CIRC and COMB exercise designs can reduce PPL associated with HFM consumption. Moreover, CIRC reduces the iAUC for insulin, suggesting additional benefits for prescribing this type of exercise.
A Comparison of Load-Velocity and Load-Power Relationships Between Well-Trained Young and Middle-Aged Males During Three Popular Resistance Exercises
Authors: Fernandes John F.T. , Lamb Kevin L. , Twist Craig
Published: May 2017

Fernandes, JFT, Lamb, KL, and Twist, C. A comparison of load-velocity and load-power relationships between well-trained young and middle-aged males during 3 popular resistance exercises. J Strength Cond Res 32(5): 1440–1447, 2018—This study examined the load-velocity and load-power relationships among 20 young (age 21.0 ± 1.6 years) and 20 middle-aged (age 42.6 ± 6.7 years) resistance-trained males. Participants performed 3 repetitions of bench press, squat, and bent-over-row across a range of loads corresponding to 20–80% of 1 repetition maximum (1RM). Analysis revealed effects (p < 0.05) of group and load × group on barbell velocity for all 3 exercises, and interaction effects on power for squat and bent-over-row (p < 0.05). For bench press and bent-over-row, the young group produced higher barbell velocities, with the magnitude of the differences decreasing as load increased (ES; effect size 0.0–1.7 and 1.0–2.0, respectively). Squat velocity was higher in the young group than the middle-aged group (ES 1.0–1.7) across all loads, as was power for each exercise (ES 1.0–2.3). For all 3 exercises, both velocity and 1RM were correlated with optimal power in the middle-aged group (r = 0.613–0.825, p < 0.05), but only 1RM was correlated with optimal power (r = 0.708–0.867, p < 0.05) in the young group. These findings indicate that despite their resistance training, middle-aged males were unable to achieve velocities at low external loads and power outputs as high as the young males across a range of external resistances. Moreover, the strong correlations between 1RM and velocity with optimal power suggest that middle-aged males would benefit from training methods which maximize these adaptations.
Seasonal Variations of Bone Metabolism and Bone Mineral Density in Collegiate Alpine Skiers
Authors: Sato Teruyuki , Sakuraba Keishoku , Tsuchiya Yosuke , Maruyama Shinya , Ochi Eisuke
Published: May 2017

Sato, T, Sakuraba, K, Tsuchiya, Y, Maruyama, S, and Ochi, E. Seasonal variations of bone metabolism and bone mineral density in collegiate alpine skiers. J Strength Cond Res 32(5): 1448–1454, 2018—This study investigated the seasonal variations in bone metabolism, mineral density, and physical characteristics in collegiate alpine skiers. Twelve male subjects (20.6 ± 1.5 years) were evaluated for body composition, bone mineral density (BMD), serum levels of osteocalcin (OC), bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase 5b (TRACP-5b), parathormone, and 25-hydroxy vitamin D. We also measured the knee extensor and flexor strength, maximal power, and vertical jump. Measurements were conducted in the preseason period (T1), competitive period (T2), end-of-season period (T3), and resting period (T4). The percentage of body fat significantly increased from T1 to T2—T4 (p < 0.05), but lean body mass significantly decreased from T1 to T2—T4 (p < 0.05). Although BMD increased at T2 (0.9%) and T3 (0.8%), as compared with that at T1 (p < 0.05), BAP and OC decreased at T2 and T3, as compared with that at T1 (p < 0.05). Tartrate-resistant acid phosphatase 5b significantly increased from T1 to T2 (p < 0.05). We concluded that it is important to monitor bone metabolism markers and BMD of male alpine skiers throughout the season.
Depression, Anxiety, and Cardiovascular Disease in Chinese: A Review for a Bigger Picture
Authors: Pan Xiong-Fei , Meng Ruiwei , Liu Na , Pan An
Published: May 2017

Cardiovascular disease (CVD) and depression and anxiety contribute substantially to the current disease burden worldwide as well as in China. Both depression and anxiety are highly prevalent among patients with CVD. We systematically reviewed the literature to disentangle the role of depression and anxiety disorders in the onset and prognosis of CVD with an emphasis on cohort studies conducted in the Chinese population. Despite the lack of large-scale prospective studies in China, the available evidence implies that both depression and anxiety are closely associated with the onset and prognosis of CVD, including ischemic heart disease and stroke, in Chinese adults. Putative behavioral and biological mechanisms are implicated in the link between depression/anxiety and CVD. Timely screening and diagnosis followed by proper treatment should be implemented for depression and anxiety in both the general population and patients with CVD. Current standard treatments such as selective serotonin reuptake inhibitors and psychotherapies are recommended for CVD patients with depression, although their efficacy for reducing CVD morbidity and mortality remains uncertain. In conclusion, prospective studies on the link between depression/anxiety and the onset and prognosis of CVD are urgently needed in the Chinese population, and more efforts are warranted to examine the efficacy of depression and anxiety treatments for CVD patients, particularly the integrated care model of including psychiatrists in a multidisciplinary clinical group.
Catheter Ablation of Atrial Fibrillation: Where Are We?
Authors: Han Xinqiang , Li Jianming
Published: May 2017

Atrial fibrillation (AF) is the commonest cardiac arrhythmia, with significant morbidity and mortality. More than half of patients with AF are still symptomatic despite adequate anticoagulation and rate control. If antiarrhythmic drugs are ineffective or poorly tolerated, AF patients are then typically treated with catheter ablation to restore sinus rhythm. In the past 20 years, AF ablation has developed from a specialized, experimental procedure into a common treatment in the cardiovascular field. Various ablation techniques and mapping technologies have been described and are continuing to evolve for increased safety and efficacy. An incomplete list of such techniques and technologies would include focal and segmental, circumferential and linear, complex fractionated atrial electrogram, ganglionated plexus, focal impulse and rotor modulation, body surface potential mapping–guided, real-time MRI–guided, cryoballoon, visually guided laser balloon, radiofrequency hot balloon, contact force sensing catheter, multielectrode catheter, and hybrid ablations. This review examines the history of invasive AF treatment and its evolution into catheter ablation but mainly focuses on the discussion of various ablation techniques and technologies leading to our current understanding of the ablation therapy of this most common arrhythmia.
Antithrombotic Therapy: Focus on the Elderly
Authors: Zhang Jingwei , Liu Meilin
Published: May 2017

Advanced age brings a higher incidence of thrombosis-related diseases. Although antithrombotic therapy significantly reduces the risk of ischemic events, relatively higher bleeding rates result in increased mortality and worse prognosis in the elderly. Thus the benefits and harms of antithrombotic drugs should to be carefully evaluated. In this review, we summarize current evidence and updated guidelines regarding antithrombotic therapy in the aging population.
Chronic Kidney Disease is a New Target of Cardiac Rehabilitation
Authors: Kohzuki Masahiro , Ito Osamu
Published: May 2017

Chronic heart failure is increasingly prevalent worldwide and is associated with significant morbidity and mortality. The Cochrane review demonstrated that cardiac rehabilitation (CR) resulted in improvements in QOL and a reduction in long-term mortality. Chronic kidney disease (CKD) is another worldwide public health problem. This review focuses on the importance and efficacy of rehabilitation for CKD patients as a new target of CR. Patients with CKD on hemodialysis (HD) have a high mortality rate, with cardiovascular diseases, such as chronic heart failure. A new systematic review and meta-analysis of randomized controlled trials reported that exercise-based renal rehabilitation improved aerobic capacity, muscular functioning, cardiovascular function, walking capacity, and QOL in CKD patients with HD. Moreover, exercise training may have renal protective effects, not only in some animal models of pre-HD CKD, but also in pre-HD CKD patients. Exercise therapy could be an effective clinical strategy in improving renal function, lowering the need for renal replacement therapy, such as HD, and reducing renal transplant risk in pre-HD CKD patients. This led the Ministry of Health, Labor and Welfare of Japan to extend renal rehabilitation partial coverage to stage 4 pre-HD CKD patients for the first time in the world in 2016.
Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma
Authors: Rao Dipti , Peitzsch Mirko , Prejbisz Aleksander , Hanus Katarzyna , Fassnacht Martin , Beuschlein Felix , Brugger Christina , Fliedner Stephanie , Langton Katharina , Pamporaki Christina , Gudziol Volker , Stell Anthony , Januszewicz Andrzej , Timmers Henri J L M , Lenders Jacques W M , Eisenhofer Graeme
Published: May 2017

Context

Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and metanephrine is unclear.

Objective

Evaluation of the additional utility of methoxytyramine compared to plasma normetanephrine and metanephrine for diagnosis of PPGLs and HNPGLs.

Design

Comparative prospective study.

Methods

Comparison of mass spectrometric-based measurements of plasma methoxytyramine, normetanephrine and metanephrine in 1963 patients tested for PPGLs at six tertiary medical centers according to reference intervals verified in 423 normotensive and hypertensive volunteers.

Results

Of the screened patients, 213 had PPGLs and 38 HNPGLs. Using an upper cut-off of 0.10 nmol/L for methoxytyramine, 0.45 nmol/L for metanephrine and age-specific upper cut-offs for normetanephrine, diagnostic sensitivity with the addition of methoxytyramine increased from 97.2% to 98.6% for patients with PPGLs and from 22.1% to 50.0% for patients with HNPGLs, with a small decrease in specificity from 95.9% to 95.1%. Addition of methoxytyramine did not significantly alter areas under receiver operating characteristic curves for patients with PPGLs (0.984 vs 0.991), but did increase (P < 0.05) areas for patients with HNPGLs (0.627 vs 0.801). Addition of methoxytyramine also increased the proportion of patients with PPGLs who showed highly positive predictive elevations of multiple metabolites (70.9% vs 49.3%).

Conclusions

While the benefit of additional measurements of plasma methoxytyramine for the detection of PPGLs is modest, the measurements do assist with positive confirmation of disease and are useful for the detection of HNPGLs.
A New Method, “Reverse Yeast Two-Hybrid Array” (RYTHA), Identifies Mutants that Dissociate the Physical Interaction Between Elg1 and Slx5
Authors: Lev Ifat , Shemesh Keren , Volpe Marina , Sau Soumitra , Levinton Nelly , Molco Maya , Singh Shivani , Liefshitz Batia , Ben Aroya Shay , Kupiec Martin
Published: May 2017

The vast majority of processes within the cell are carried out by proteins working in conjunction. The Yeast Two-Hybrid (Y2H) methodology allows the detection of physical interactions between any two interacting proteins. Here, we describe a novel systematic genetic methodology, “Reverse Yeast Two-Hybrid Array” (RYTHA), that allows the identification of proteins required for modulating the physical interaction between two given proteins. Our assay starts with a yeast strain in which the physical interaction of interest can be detected by growth on media lacking histidine, in the context of the Y2H methodology. By combining the synthetic genetic array technology, we can systematically screen mutant libraries of the yeast Saccharomyces cerevisiae to identify trans-acting mutations that disrupt the physical interaction of interest. We apply this novel method in a screen for mutants that disrupt the interaction between the N-terminus of Elg1 and the Slx5 protein. Elg1 is part of an alternative replication factor C-like complex that unloads PCNA during DNA replication and repair. Slx5 forms, together with Slx8, a SUMO-targeted ubiquitin ligase (STUbL) believed to send proteins to degradation. Our results show that the interaction requires both the STUbL activity and the PCNA unloading by Elg1, and identify topoisomerase I DNA–protein cross-links as a major factor in separating the two activities. Thus, we demonstrate that RYTHA can be applied to gain insights about particular pathways in yeast, by uncovering the connection between the proteasomal ubiquitin-dependent degradation pathway, DNA replication, and repair machinery, which can be separated by the topoisomerase-mediated cross-links to DNA.
Efeito da terapia LED na disfunção temporomandibular: estudo de caso
Authors: Costa Davidson Ribeiro , Costa David Ribeiro , Pessoa Diego Rodrigues , Masulo Leandro Júnio , Arisawa Emília Ângela Lo Schiavo , Nicolau Renata Amadei
Published: May 2017

*** Effect of LED therapy on temporomandibular disorder: a case study ***AIMS: To evaluate the effect of light emitting diode (LED) therapy on temporomandibular disorder.CASE DESCRIPTION: A woman diagnosed with temporomandibular disorder was subjected to four LED therapy sessions at a seven-day interval. In the initial examination of the temporomandibular joint the patient presented a mouth opening without pain of 23 mm, a maximum opening of 25 mm and a maximum opening with the aid of 27 mm. After the treatment, there was an increase of 7 mm in the opening without pain between the first and last evaluation, while the maximum opening of the mouth and the maximum opening with aid increased 6 mm between the first and last evaluation. After 21 days of treatment, a 50% reduction in painful sites was detected on the palpation examination. After the end of the treatment, the visual analog pain scale detected a decrease in pain intensity on both sides, and there was a decrease in the total mean pain intensity. By analyzing the responses to the Medical Outcomes Study 36-item Short Form Health Survey (SF-36), of the eight quality of life domains evaluated, four showed improvement. CONCLUSIONS: In this case study, after LED therapy there was reduction in pain intensity and increase of the mandibular range of motion. The resolution of the signs and symptoms of temporomandibular disorder resulted in patient’s better quality of life.
Terapia baseada em realidade virtual usando o Leap Motion Controller para reabilitação do membro superior após acidente vascular cerebral
Authors: Soares Nayron Medeiros , Pereira Gabriela Magalhães , Figueiredo Renata Italiano da Nóbrega , Morais Gleydson Silva , De Melo Sandy Gonzaga
Published: May 2017

*** Virtual reality therapy using the Leap Motion Controller for post-stroke upper limb rehabilitation ***AIMS: To evaluate the applicability of a virtual reality-based motion sensor for post-stroke upper limb rehabilitation.CASES DESCRIPTION: Three post-stroke patients were subjected to virtual reality training for rehabilitation of their upper limbs using the Leap Motion Controller technology and the game Playground 3D® for 3 consecutive days. On the first and last days, the Box and Blocks test, the De Melo Eye-Hand Coordination Test, and transcranial magnetic stimulation were applied. On the last day, the patients were evaluated with the Experience Evaluation Form. After the proposed training, a lower motor threshold was observed in both cerebral hemispheres, as well as better performance in the tests that evaluated hand and eye-hand coordination skills. The proposed therapy was well received by the patients.CONCLUSIONS: No adverse effects were observed, and promising and precise results were obtained for the virtual reality-based training using the Leap Motion Controller and Playground 3D®. The training allowed patients to have an active role in the rehabilitation of stroke-induced upper limb sequelae.
Atitudes de professores e futuros professores em relação à Matemática
Authors: Faria Paulo Cézar , Moro Maria Lucia Faria , Brito Márcia Regina Ferreira de
Published: May 2017

O estudo compara a existência e a direção da atitude em relação à Matemática de quatro grupos amostrais: estudantes de licenciatura em matemática em dois momentos de sua formação, e professores de matemática em dois momentos de exercício profissional. Os dados foram obtidos de participantes voluntários (N = 440), por meio de escala de atitude, texto autobiográfico, questionário e entrevista semi-estruturada. A análise estatística dos dados permitiu constatar diferenças na medida de atitudes em relação à Matemática entre os grupos amostrais, sendo significativa a presença de atitude favorável de alunos do início da licenciatura em comparação à de professores em exercício. Essas diferenças foram corroboradas por traços característicos dos tipos de atitude, identificados por análise qualitativa. A mudança de atitude em relação à Matemática pode ser explicada pelas particularidades das diferentes circunstâncias da vida estudantil e profissional. Recomendações para a formação docente em Matemática são sugeridas.
Adaptação do questionário sobre significados do trabalho - QST - para o Brasil
Authors: Goulart Patrícia Martins
Published: May 2017

Este artigo discorre sobre o processo de adaptação do Questionário sobre Significados do Trabalho - QST - no Brasil. Este instrumento se constitui de dois inventários e quatro escalas com fatores relacionados a significados, percepções, atribuições, valores e atitudes com relação ao ato de trabalhar. Os procedimentos metodológicos para a validação deste instrumento consistiram nas etapas de revisão e sistematização das bases teórico-empíricas sobre as quais se constrói a versão original do QST, a administração do instrumento piloto e o pré-teste da versão adaptada em um total de 680 pessoas. Participaram deste processo adultos jovens, dos sexos masculino e feminino, de categorias de trabalho heterogêneas e diferentes níveis de formação acadêmica e de renda. Os dados psicométricos do instrumento apresentam alta consistência interna para o total dos itens dos inventários e escalas, e evidenciam que a versão em português do QST mostra-se adequada à administração no contexto brasileiro.
Trabalho, adoecimento e histórias de vida em trabalhadoras da indústria calçadista
Authors: Ramos Márcia Ziebell , Bianchessi Desirée Luzardo Cardozo , Merlo Álvaro Roberto Crespo , Poersch Ana Luisa , Veeck Critiane , Heisller Simone Zanotelli , Vieira Jean Alexandre
Published: May 2017

Os portadores de Lesões por Esforços Repetitivos (LER/DORT), além das queixas de dores osteomusculares, manifestam sofrimento psíquico relacionado ao adoecimento. Nesta investigação, buscou-se, por meio do método das Histórias de Vida, compreender como se constituíram as relações sociais de trabalho e os processos de adoecimento de trabalhadoras portadoras de LER/DORT, oriundas da indústria calçadista do Rio Grande do Sul, atendidas no Ambulatório de Doenças do Trabalho do Hospital de Clínicas de Porto Alegre. Realizaram-se entrevistas individuais abertas, que foram transcritas e analisadas. As recorrências e as singularidades presentes nos depoimentos originaram cinco categorias temáticas: trabalho infantil; baixa escolaridade e início da trajetória de trabalho na indústria calçadista; relação de prazer e sofrimento com o trabalho; marcas do trabalho no corpo; e afastamento do trabalho e sofrimento. As histórias destas trabalhadoras apontaram para as vivências de culpa, fracasso e exclusão, por não mais poderem desempenhar o que lhes é socialmente esperado: o trabalho.
Atribuições de causas ao desemprego e valores pessoais
Authors: Gondim Sonia Maria Guedes , Estramiana José Luis Álvaro , Luna André de Figueiredo , Oliveira Thiago Santana Souza de , Souza Graceane Coelho de
Published: May 2017

O artigo explorou a associação entre atribuições de causas ao desemprego e valores pessoais. Participaram do estudo 205 pessoas empregadas e desempregadas. Utilizou-se uma escala de atribuição sobre as causas do desemprego baseada em Furnham (1982), o Perfil de Valores Pessoais (PVQ 21 - versão breve) de Schwartz incluído no European Social Survey (ESS) e um questionário sociodemográfico. Desempregados e empregados não diferem significativamente em relação às atribuições de causas do desemprego. Em relação aos valores, enquanto os desempregados apresentam valores de universalismo e benevolência, ligados à dimensão de autotranscedência, os trabalhadores empregados apresentam valores de segurança, ligados à dimensão de conservadorismo. Finalmente, encontrou-se uma associação significativa entre atribuições fatalistas e valores de tradição e segurança, entre atribuições sociais e valores de tradição, e entre atribuições individuais e valores de estimulação.
Una aproximación a los postgrados e investigación en psicología paraguaya
Authors: Coppari Norma B.
Published: May 2017

El derrotero histórico del país, en materia de desarrollo científico y tecnológico, muestra ausencia o peso insignificante, en las políticas de los gobiernos. En particular, los postgrados en Psicología han sido esporádicos, de cuestionable calidad y de escasa trascendencia en el contexto académico y profesional. Se requiere la implementación y fortalecimiento de políticas educativas de calidad y sistemáticas en educación superior y en especial de la formación científica en básica, aplicada y tecnológica. Se destacan los Tratados del MERCOSUR en formación, la creación de ANEAES (2003) para los procesos de acreditación de la calidad, y la labor de la SPPs para la Ley de Colegiatura. El siglo XXI espera por una Psicología Paraguaya fortalecida en su perfil científico-practicante local frente a desafíos regionales y mundiales.