bluuebunny/crossref_metadata_2025 huggingface dataset:
Randomization of Left-Right Asymmetry and Congenital Heart Defects
Authors: Nöthe-Menchen Tabea , Wallmeier Julia , Pennekamp Petra , Höben Inga M. , Olbrich Heike , Loges Niki T. , Raidt Johanna , Dougherty Gerard W. , Hjeij Rim , Dworniczak Bernd , Omran Heymut ,   the PCD study group*, Amirav Israel , Biebach Luisa , Fabricius Dorit , Griese Matthias , Große-Onnebrink Jörg , Häffner Karsten , Hector Andreas , Jung Andreas , Kaiser-Labusch Petra , Kaiser Thomas , Keßler Christina , Kitz Richard , Knowles Michael R. , Koerner-Rettberg Cordula , Kristoffersson Ulf , Leigh Margaret W. , Mertsch Pontus , Mischo Bernhard , Nielsen Kim G. , Poeta Marco , Rietschel Ernst , Roth Samra , Santamaria Francesca , Schmalstieg Christian , Schmidts Miriam , Schwarz Carsten , Schwerk Nicolaus , Seithe Horst , Tebbe Johannes , Werner Claudius , Zariwala Maimoona A.
Published: November 2019

Background:

Nearly one in 100 live births presents with congenital heart defects (CHD). CHD is frequently associated with laterality defects, such as
situs inversus
, a mirrored positioning of internal organs. Body laterality is established by a complex process: monocilia at the embryonic left-right organizer facilitate both the generation and sensing of a leftward fluid flow. This induces the conserved left-sided Nodal signaling cascade to initiate asymmetrical organogenesis. Primary ciliary dyskinesia originates from dysfunction of motile cilia, causing symptoms such as chronic sinusitis, bronchiectasis and frequently
situs inversus totalis
. The most frequently mutated gene in primary ciliary dyskinesia,
DNAH5
is associated with randomization of body asymmetry resulting in
situs inversus totalis
in half of the patients; however, its relation to CHD occurrence in humans has not been investigated in detail so far.

Methods:

We performed genotype/phenotype correlations in 132 patients with primary ciliary dyskinesia carrying disease-causing
DNAH5
mutations, focusing on
situs
defects and CHD. Using high-speed video microscopy-, immunofluorescence-, and in situ hybridization analyses, we investigated the initial steps of left-right axis establishment in embryos of a
Dnah5
-mutant mouse model.

Results:

In patients with primary ciliary dyskinesia carrying disease-causing
DNAH5
mutations, 65.9% (87/132) had laterality defects: 88.5% (77/87) presented with
situs inversus totalis
, 11.5% (10/87) presented with
situs ambiguus
; and 6.1% (8/132) presented with CHD. In
Dnah5
mut/mut
mice, embryonic left-right organizer monocilia lack outer dynein arms resulting in immotile cilia, impaired flow at the left-right organizer, and randomization of Nodal signaling with normal, reversed or bilateral expression of key molecules.

Conclusions:

For the first time, we directly demonstrate the disease-mechanism of laterality defects linked to DNAH5 deficiency at the molecular level during embryogenesis. We highlight that mutations in
DNAH5
are not only associated with classical randomization of left-right body asymmetry but also with severe laterality defects including CHD.
A new species of Neolycaena de Nicville, 1890 (Lepidoptera, Lycaenidae) from the Dzhungarian Gobi desert, Mongolia
Authors: CHURKIN SERGEI V. , KOLESNICHENKO KIRILL A.
Published: November 2019

Neolycaena enkhnasani sp. n. is described from the Dzhungarian Gobi desert. The food plant is Halimodendron halodendron (Fabacea). The new species is distinguished from the related taxa known from East Kazakhstan by small size, dense gray suffusion on the hindwing underside, a delicate and partly reduced submarginal underside pattern as well as the characters of the genitalia: the shape of the valva in males and the shape of the antrum in females. Important new data about the distribution and distinctions of N. zaisana (Zhdanko, 2013) and N. balchaschensis Zhdanko, 1998 are published together with photos of the genitalia of all the three taxa.
Significance of material constitutive model and forming parameters on the crashworthiness performance of capped cylindrical tubular structures
Authors: A Praveen Kumar , Akbar Afdhal , Jusuf Annisa , Gunawan Leonardo
Published: November 2019

An accuracy of crushing performance indicators is critical to evaluate in finite element crushing simulations particularly for the press-formed capped tubular energy absorbing structures. It is essential to select the appropriate material constitutive model and to incorporate the forming parameters into the finite element crushing model as a vital input. Hence in the present article, the influence of various material constitutive models and forming (multi-stage deep drawing) parameters on the axial crashworthiness characteristics of thin-walled capped cylindrical tubes were investigated numerically. Both forming and crushing simulations were executed by nonlinear finite element LS-DYNA® code. The forming parameters such as thickness distribution, residual stress, and effective plastic strain were mapped to a finite element crushing model of the tube. The numerical predictions of the thickness distribution and final deformed profiles of the capped cylindrical tubes are correlated with the experiments. The results revealed that the forming parameters have a substantial effect on the crushing performance of the deep drawn capped cylindrical tubes. As a result of these analyses, the thickness and strain predictions strengthens the tube and significantly influenced the crushing performance indicators such as initial peak crushing force, mean crushing force, and the energy absorbing capacity.
Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer
Authors: Hu Yue-Xin , Zheng Ming-Jun , Zhang Wen-Chao , Li Xiao , Gou Rui , Nie Xin , Liu Qing , Hao Ying-Ying , Liu Juan-Juan , Lin Bei
Published: November 2019

Aim

Cervical cancer is a common malignant carcinoma of the gynecological tract with high morbidity and mortality. Therefore, it is crucial to elucidate the pathogenesis, prevention, diagnosis and prognosis of cervical cancer by searching for the involved key genes.

Method

In this study, the alternative splicing (AS) events of 253 patients with cervical cancer were analyzed, and 41,766 AS events were detected in 9961 genes. Univariate analysis was performed to screen prognostic AS events. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was used to identify the pathways in which these AS events were involved.

Results

We found that exon skip (ES) is the main AS event in patients with cervical cancer. There was pronounced consistency between the genes involved in overall survival and those involved in recurrence. At the same time, we found that a gene may exhibit several different types of AS events, and these different AS events may be related to prognosis. Four characteristic genes, HSPA14, SDHAF2, CAMKK2 and TM9SF1, that can be used as prognostic markers for cervical cancer were selected. Conclusion: The importance of AS events in the development of cervical cancer and prediction of prognosis was revealed by a large amount of data at the whole genome level, which may provide a potential target for cervical cancer treatment. We also provide a new method for exploring the pathogenesis of cervical cancer to determine clinical treatment and prognosis more accurately.
ESR statement on new approaches to undergraduate teaching in Radiology
Authors:   European Society of Radiology (ESR)
Published: November 2019

Medical education is evolving and electronic learning (e-Learning) strategies have now become an essential asset in radiology education. Radiology education is a significant part of the undergraduate medical curriculum and the use of e-Learning in radiology teaching in medical schools is on the rise. If coupled with clinical decision support systems, e-Learning can be a practical way of teaching students clinical decision making, such as selecting the diagnostic imaging tests that are best suited in certain clinical scenarios.

The innovative concept of flipped classroom learning encourages students to work independently and maximises the application of learnt contents in interactive classroom sessions.

For integrated curricula with their student-centred, problem-based, and community-based design, an approach to systematically integrate radiology may be to define diagnostic reasoning as one of the core goals. Radiologists as teachers and scholars may understand themselves as experts in diagnostic reasoning and in mentoring how to make medical decisions.

Computer programs simulating the routine work are available and can be used to teach the recognition of anatomical structures and pathological patterns, and also to teach ultrasonography and interventional radiology, maximising patient safety.
The imagination of eco-disaster: Post-disaster rebuilding in Asian cinema
Authors: Chu Kiu-wai
Published: November 2019

Commercial films today often reduce representations of natural catastrophes to commodified spectacles that de-contextualize the subject matter. To contemporary film viewers, the ‘psychic numbing’ effect is apparent, and it does not apply merely to our perception of numbers, statistics, the big data. It can also be seen when we are bombarded with similar kinds of images over and over again; in this case, the large-scale tsunami, the hurricanes, the earthquake and all the exaggerated destruction scenes in recent disaster movies have become clichés no matter how realistic and intense the shots are made. By focusing on a range of eco-disaster films, this article highlights the importance of cultural sensitivity in the study of eco-disaster films, by exploring several questions: how are eco-disasters culturally shaped and defined, via cinematic means? How are human responses to disasters, as reflected in cinematic representations, shaped by specific sociopolitical, cultural or economic conditions? How does cinema as a media form represent ecological concepts that are shared globally or universally, while at the same time reflecting specific cultural characteristics? Juxtaposing examples from China, Thailand and the Phillippines, particularly with three films: Wonderful Town (Thailand, 2007), Aftershock (China, 2010) and Taklub (Phillippines, 2015), this article demonstrates how Asian eco-disaster films in the Anthropocene epoch reflect specific cultural imaginations of nation and identity rebuilding, which in turn provide a ground to reposition, redefine and reinvent the changing cultural identities in contemporary Asia. Eventually, it argues that eco-disaster narratives in Asia reflect the identity crisis of Asian nations in a global capitalist world, just as much as they are about ecological crises.
Growth hormone deficiency in adults. Introduction to the problem
Authors: Bengt-Ake Bengtsson М.
Published: November 2019

Growth hormone deficiency (GH) for a long time was recognized only in childhood. Compelling evidence has been obtained showing that HR replacement therapy effectively stimulates growth and, in many cases, achieves normal end-points of physical development. More recently, it was shown that the most effective in this regard was the appointment of regular evening injections of the drug, which mimic the physiological secretion of GH during sleep. Despite the fact that the acceleration of linear growth is the most objective criterion for the effectiveness of therapy for GH, it is known that GH has a significant effect on body structure, causing a decrease in fat mass and an increase in muscle mass.

Until recently, GH was not considered an important hormonal regulator in adults, and therefore, there was no study of GH deficiency and treatment of children with GH deficiency when they reached adulthood, as well as patients with hypopituitarism who became ill in adulthood. However, in 1989, as a result of two double-blind trials using placebo in the control group, the effectiveness of GH replacement therapy in adults with an abnormally low level of GH, up to a severe degree of GH deficiency, was revealed. Further studies showed the presence of violations of both physical and mental status in adults in whom GH deficiency develops as a result of the tumor process in the pituitary gland or its therapy. Most of these disorders, but not all, can be corrected as a result of GH replacement therapy, which confirms the significant effect of GH throughout life.
Increasing potato equivalent yield increases returns to investment under potato-legume intercropping systems
Authors: Gitari Harun I , Nyawade Shadrack O , Kamau Solomon , K Gachene Charles K. , Karanja Nancy N , Schulte-Geldermann Elmar
Published: November 2019

In order to enhance sustainable intensification of potato-based cropping systems, especially in sub-Saharan Africa (SSA), there is a need to investigate the economic viability of investing in this lucrative venture. This study evaluated the economic returns under legume intercropping systems using value/cost ratio (VCR) and benefit/cost ratio (BCR) under treatments comprising of potato intercropped with dolichos (Lablab purpureus L.) (P-D), climbing bean (Phaseolus vulgaris L.) (P-B) and garden pea (Pisum sativum L.) (P-G), and a potato pure stand control (P-S). Across the seasons, tuber yield was not significantly (p < 0.05) affected by intercropping with P-D, whereas under P-B and P-G, it decreased by 19% and 16%, respectively compared to P-S. P-G, P-B and P-D recorded 6, 7 and 12% higher potato equivalent yield (PEY) relative to P-S. P-D was the most profitable intercropping system with VCR of 35 and BCR of 5.1 as compared to values recorded in P-S of 31 and 5, respectively. Regression of VCR against PEY resulted in a stronger coefficient (0.98) compared to that of BCR against PEY (0.82) implying that VCR is a simple tool that could be adopted for economic returns to investment studies such as potato-legume inter-cropping systems.
An Activating Mutation in ERK Causes Hyperplastic Tumors in ascribbleMutant Tissue inDrosophila
Authors: Kushnir Tatyana , Bar-Cohen Shaked , Mooshayef Navit , Lange Rotem , Bar-Sinai Allan , Rozen Helit , Salzberg Adi , Engelberg David , Paroush Ze’ev
Published: November 2019

Excessive RTK signaling, often caused by activating mutations in Ras, Raf and/or MEK, occurs in most human tumors. Intriguingly, confirmed cancer-driver mutations in the downstream effector kinase, ERK, have not been reported. To test if...

Receptor tyrosine kinase signaling plays prominent roles in tumorigenesis, and activating oncogenic point mutations in the core pathway components Ras, Raf, or MEK are prevalent in many types of cancer. Intriguingly, however, analogous oncogenic mutations in the downstream effector kinase ERK have not been described or validated in vivo. To determine if a point mutation could render ERK intrinsically active and oncogenic, we have assayed in Drosophila the effects of a mutation that confers constitutive activity upon a yeast ERK ortholog and has also been identified in a few human tumors. Our analyses indicate that a fly ERK ortholog harboring this mutation alone (RolledR80S), and more so in conjunction with the known sevenmaker mutation (RolledR80S+D334N), suppresses multiple phenotypes caused by loss of Ras-Raf-MEK pathway activity, consistent with an intrinsic activity that is independent of upstream signaling. Moreover, expression of RolledR80S and RolledR80S+D334N induces tissue overgrowth in an established Drosophila cancer model. Our findings thus demonstrate that activating mutations can bestow ERK with pro-proliferative, tumorigenic capabilities and suggest that Drosophila represents an effective experimental system for determining the oncogenicity of ERK mutants and their response to therapy.
The Journey of Turk Sindbad: Question of Determination the Source of Lithuanian Tatar Texts Written in Slavic Using Arabic Characters
Authors: Miškinienė Galina
Published: November 2019

This article talks about the problem of determining the source of Lithuanian Tatar manuscripts written in Slavic using Arabic characters. Among the sources used by manuscript writers, there should be a clear distinction between Muslim and non-Muslim sources. Surah (chapter) of the Quran, separate Aja (verse), Hadiths, texts about the life of the prophets from different books and prayers were one of the main sources of Arabic insertions. Tora, The Bible, and the Psalms of David are the most popular non-Muslim sources.The goal of our research is to determine the source of The Journey of Turk Sindbad text from the Poltorzicki manuscript (1830). In this article is presented a thorough description of the text. The researcher tells general assumptions regarding the used source, describes the phonetic, lexical, grammatical, graphic, and orthographic peculiarities of the text.
Tata laksana Pasien Gravida 29–30 Minggu dengan Gagal Napas ec. Hypokalemic Periodic Paralysis yang Diperberat dengan Community Acquired Pneumonia
Authors: Gunadi Mariko , Suwarman Suwarman , Kestriani S Nurita Dian
Published: November 2019

Penatalaksanaan sakit kritis pada wanita hamil memiliki karakteristik yang unik karena  perubahan fisiologi selama kehamilan dan janin yang berkembang dalam uterus yang mendapat implikasi yang signifikan. Pada kasus ini, seorang perempuan 27 tahun yang sedang hamil gemeli usia kehamilan 29–30 minggu datang ke Instalasi Gawat Darurat (IGD) Rumah Sakit Dr. Hasan Sadikin Bandung dengan keluhan utama kelemahan keempat anggota gerak. Hasil pemeriksaan laboratorium didapatkan kadar kalium sangat rendah dan didiagnosis dengan hypokalemic periodic paralysis. Pasien mengalami gagal napas  sehingga dilakukan intubasi dan diberikan bantuan ventilasi mekanik, kemudian dirawat di Intensive Care Unit (ICU). Gagal napas disertai penyulit community acquired pneumonia. Tata laksana ventilasi mekanik pada wanita hamil di ICU bersifat suportif dengan teknik sama seperti pada pasien tidak hamil, namun memiliki target khusus yang berbeda. Monitoring fetal heart rate (FHR) dapat mencerminkan kesejahteraan janin dan kondisi ibu. Tujuan penulisan laporan kasus ini adalah mengetahui pentingnya target pemberian ventilasi mekanik dan melakukan monitoring FHR pada pasien hamil di ICU. Management of Respiratory Failure Due to Hypokalemic Periodic Paralysis Complicated with Community Acquired Pneumonia in 29–30 Weeks of GestationManagement of critically ill pregnant women in Intensive Care Unit (ICU) has unique characteristics due to the physiological changes during pregnancy and the presence of growing fetus in the uterine which may present significant implications. This study presented a case of a 27 years old woman with 29–30 weeks of gestation of twin pregnancy who came to Emergency Room (ER) with the chief complaint of weakness in both lower and upper extremities. Laboratory investigations showed a very low potassium level and the patient was diagnosed with hypokalemic periodic paralysis. Patient then experienced respiratory failure at the ER, intubated, and mechanically ventilated and was sent to the ICU. Community-acquired pneumonia was complicating the respiratory failure. Basically, mechanical ventilation management for pregnant patient in ICU is supportive in nature and uses the same techniques employed for the non-pregnant patient. However, the goals are different as it is important to monitor fetal heart rate (FHR) in pregnant woman as this does not only reflect the fetal well-being but also the maternal condition. This case report is intended to show the importance of mechanical ventilation goal and FHR monitoring in pregnant patients in ICU.
Pankreas Kanserinde Hedefsel Nanopartikül Tedavisi ve Klinik Denemeler
Authors: KAYA Kaya , İYİÖZ Sude , KAYACAN Bensu , ABİT Hatice , ŞENYİĞİT Şeyma Ceren , ÖZBALCI Furkan İlker , GÜRBÜZ Nilgün
Published: November 2019

Mortalitesi en yüksek kanser türleri arasında yer alan pankreas kanserinin günümüzde klinik tedavisinde kullanılan kemoterapötik ajanlar, hastalarda sağkalım süresini uzatmada ve pankreas kanserinin ölümcül etkilerini ortadan kaldırmakta yetersiz kalmaktadır. Çeşitli kemoterapötik ajanların, albumin gibi proteinlerle kombine edilerek tedavi için hastalara verilmesi sonucu sağkalım süresinin yaklaşık 1 - 2 ay uzadığı fakat ciddi yan etkilerin meydana geldiği gözlenmiştir. Pankreas kanserinin daha etkin tedavisinin sağlanması için selektif olarak sağlıklı hücreden ziyade hedefsel olarak kanser hücresine yönelik terapötik yaklaşımlara ihtiyaç duyulmaktadır. Tam da bu noktada hedefsel tedavilerin sağlanmasında nanopartikülün önemi son yıllarda öne çıkmakta olup yapılan çalışmalar, nanopartikül ile kaplı hem hidrofilik hem de hidrofobik karakterdeki ilaçların ayrı ayrı veya beraberce verilebildiği yeni tedavi yaklaşımlarının pankreas kanserinde umut verici sonuçlara ulaştığını göstermiştir. Genel olarak solid tümörler için günümüzde faz aşamasında veya faz aşamasını geçmiş olan nanopartikül bazlı hedefsel ilaç denemeleri bulunmakla birlikte, bunlardan 15-20 tanesi Faz 2 ve Faz 3 aşamasında olup klinik denemeleri devam etmektedir. Kolesterol, fosfokolin gibi nötral lipidlerden, katyonik lipidlerden ve polietilenglikol (PEG) ile konjuge edilmiş lipidlerden oluşan nanotaşıyıcılar, hedefsel olarak pankreas kanseri hücrelerine ilaç taşınmasında etkin rol oynamaktadırlar. Bu nanotaşıyıcıların yüzeyine kovalent bir şekilde yerleştirilen aptamer, folat, tripeptit, antikor gibi moleküller hedefe spesifik ilaç iletimini sağlamaktadır. Nanolipozomlar ile taşınan siRNA veya miRNA gibi oligonükleotidler, peptit ve proteinler, hidrofilik ve hidrofobik ilaçlar direkt olarak kanser hücrelerinin içerisine hedefe yönelik olarak ulaşabilmektedirler. Bu sayede nanopartikül aracılı hedefsel tedavi ile, daha az dozda ilaç alımı ve ilaçların vücut içerisindeki toksik etkisinin azaltılması da sağlanmış olur. Yapılan çalışmalar sonucunda elde edilen olumlu veriler ışığında, hedefe yönelik nanopartikül bazlı tedavi türlerinin geliştirilmesi pankreatik kanser tedavisinde yeni bir umut olacaktır.
Holocene Rupture History of the Central Teton Fault at Leigh Lake, Grand Teton National Park, Wyoming
Authors: Zellman Mark S. , DuRoss Christopher B. , Thackray Glenn D. , Personius Stephen F. , Reitman Nadine G. , Mahan Shannon A. , Brossy Cooper C.
Published: November 2019

Prominent scarps on Pinedale glacial surfaces along the eastern base of the Teton Range confirm latest Pleistocene to Holocene surface-faulting earthquakes on the Teton fault, but the timing of these events is only broadly constrained by a single previous paleoseismic study. We excavated two trenches at the Leigh Lake site near the center of the Teton fault to address open questions about earthquake timing and rupture length. Structural and stratigraphic evidence indicates two surface-faulting earthquakes at the site that postdate deglacial sediments dated by radiocarbon and optically stimulated luminescence to ∼10–11  ka. Earthquake LL2 occurred at ∼10.0  ka (9.7–10.4 ka; 95% confidence range) and LL1 at ∼5.9  ka (4.8–7.1 ka; 95%). LL2 predates an earthquake at ∼8  ka identified in the previous paleoseismic investigation at Granite Canyon. LL1 corresponds to the most recent Granite Canyon earthquake at ∼4.7–7.9  ka (95% confidence range). Our results are consistent with the previously documented long-elapsed time since the most recent Teton fault rupture and expand the fault’s earthquake history into the early Holocene.
Interpreting China: A Study of Five Issues of Arquitectura Viva about contemporary Chinese Architecture
Authors: Li Xiangning Wanli Mo and
Published: November 2019

Since2004,ArquitecturaViva,arenownedSpanisharchitecturaljournal,haspublished fiveissuesoncontemporaryarchitecturalpracticesinChina.Threeofthemofferdistinct perspectives through essays and projects,theseinclude:China Boom(AVMonografias 109-110) from 2004, Made in China (AV Monografias 150) from 2011, and Timeless China (Arquitectura Viva 180) published in 2015. Two more issues were devoted to the architecture of global events: Olympic Beijing (Arquitectura Viva 118-119) from 2008 and Shanghai 2010 (Arquitectura Viva 129) put out for the 2010 EXPO. Published over a span of a decade, these five issues interpret a contemporary image of China from different perspectives with respect to architectural practices while building a narrative based on the journal’s underlying value orientation. Based on a close reading of these five issues in respect to editorial statements, issue structure and project choice, as well as an interview with their editor-in-chief, this essay attempts to shed light on the journal’s latent value orientation, while simultaneously offering a reflection on these values.
Suburban Villages: Conceptualizing Urban Fringes in a Global Context. The Case of Wangzhai
Authors: Duvallon Vincent Peu
Published: November 2019

Early settlements, or “Suburban Villages,” are organized along the Wenruitang water network, a millenary old canal system which structured the territory around Wenzhou. The extension of the urban boundaries from the late 1980’s onward included the rural villages along the Wenruitang in a form of diffused urbanism. Those villages became linked to create an Urban Archipelago, deﬁning an indigenous kind of suburbs. At present, the sevillages are threatened by the constant mutating character of this suburb: the agricultural land preservation policy will preserve the diffuse urban form but puts the burden on the already built areas, i.e. the suburban villages, as the only place of redevelopment, and real estate speculation. Ourresearchprojectaimstodeﬁnethismutatingterritoryandfocusparticularlyonthe relation between the Wenruitang water system and the settlements, within this new suburban situation. Our goal is to show the patterns of its architecture and urbanism in order to propose either a preservation and rehabilitation plan. OurﬁrstcasestudyisthevillageofWangzhaiinWenzhouinZhejiangProvince.Located on one branch of the Wenruitang water network, Wangzhai village is both typical and speciﬁc. As part of these Suburban Villages network, it is typical with its relation to the river, its spontaneous urban development, and its modern vernacular architecture heritage. However it is located within the boundaries of the Sino-American Wenzhou-Kean University, and is part of the planned Kean Town. The objective of our research is to examine the condition of the village in order to propose conceptual tools that might be used for design strategies.
Built Environment Education Across Boundaries. The Case of Energy Retroﬁt As a Tool for Low Carbon Transition
Authors: Sibilla Maurizio , Kurul Esra
Published: November 2019

Since the 1990s, several studies have focused on the concept of Transformative Pedagogy as a strategy to foster inter-disciplinary abilities to rise to the challenge of sustainable development. Although the impact of these transformative pedagogies is widely recognized, their integration in traditional educational programmes is often neglected, speciﬁcally in programmes that develop future practitioners in the built environment(BE).In this realm,research has promoted the integration across disciplines as key element to build locally appropriate technological solutions to deal with energy issues that building and urban scales. However,the lack of inter-disciplinary training and tools necessary to support the understanding of complex problems within an inter-disciplinary context has remained an issue. This project deals with this lacuna by developing an innovative learning platform for knowledge integration in Energy Retroﬁt(ER).This paper starts with an overview of the methodological approach,which was used to conﬁgure the main structure of the cognitive tool (i.e., cmapER). Then, the results of the workshop which involved twelve senior researchers with different backgrounds (e.g. economists, architects, planners, engineers and project managers) in a mutual process of knowledge exchange, are presented. The main ﬁndings point out a set of new functionalities and properties of the CmapER as a cognitive tool that canstimulateinterdisciplinaryperspectivesinER.Thiscontributionrepresentsafurther development on the combined use of cognitive mapping technique and meaningful learning activities in the realm of BE disciplines.
Explorations: Teaching and Research Methods Beyond Boundaries
Authors: Setti Giulia
Published: November 2019

The essay shows a critical reﬂection on different forms of intensive courses (such as workshops and seminars) and on possible design outcomes. The research studies how to teach architectural design subjects is changing and how forms of ‘open’ learning could help to overcome barriers and disciplinary boundaries. In particular, the essay describes some experiences of intensive workshops conducted in recent years by the Politecnico di Milano in collaboration with Universities in China and India, supporting on one hand a better and deeper knowledge of other contexts, on the other, questioning the traditional teaching methodologies of the architectural design in favor of more dynamic processes. The investigated contexts lead students to reﬂect on the meaning of the architectural design and on its different forms in contemporary scenarios. The article describes the deﬁnition of these research and design activities and the principles that led to the formulation of programs and topics, useful to form student more aware of dynamic sand transformations underway in contemporary cities.
Urban Renewal Design-A Probe into the Reconstruction Mode of Urban Villages in Xi’an
Authors: Liu Xiaojie
Published: November 2019

Theproblemofvillagesinthecityisaproblemleftoverbythehistoryofdifferentstages of urban development.Itislikeapieceof” urban psoriasis”that affects the construction of the future city. How to explore a reasonable urban village reconstruction mode is of great signiﬁcance for the future development of the city. In this paper, based on the investigation and analysis of the existing urban village construction environment in Xi’an, the author proposes the imagination of future living space mode of the village in the city, and explores how to transform the existing construction environment space of thevillageinXi’anCitytoreconstructthenewurbanpubliclivingspace,thus effectively driving the urban regional vitality, reasonably integrating villages in the City into the existing urban space development, and giving the village a new function and vitality.
Oscillation Criteria for Third Order Neutral Generalized Difference Equations with Distributed Delay
Authors: Reddy P.Venkata Mohan , Manuel M.Maria Susai , Kilicman Adem
Published: November 2019

This paper aims to investigate the criteria of behaviour of certain type of third order neutral generalized difference equations with distributed delay. With the technique of generalized Riccati transformation and Philos-type method, some oscillation criteria are obtained to ensure convergence and oscillatory solution of suitable example is listed to illustrate the main result.
Identification and Preference of Game Styles in LaLiga Associated with Match Outcomes
Authors: Castellano Paulis Julen , Pic Miguel
Published: November 2019

The objective was to model the teams’ style of play (SoP) in elite football and relate them to the match result. For this, the twenty Spanish first division teams in the 2016-17 season were analysed, using nine interaction performance indicators (IRi). A principal component (PC) analysis was applied. From two PCs four SoPs were established: deep or high-pressure defending, and elaborate or direct attack. The SoPs were distributed according to average performance obtained throughout the championship. The connection between the preferred SoP and the final result was estimated. Teams with elaborate offensive styles and teams defensively minded got better results. In addition, most of the teams showed variability in their SoP. The applications of the study are: 1) the IRi have served to identify SoP and can be used as a reference to optimize team performance; 2) teams should have a varied SoP repertoire, as well as being prepared to deal with different SoPs; 3) particular player profiles should be connected with the desired SoP when creating the squad. 4) clubs should develop a varied range of SoPs at their academies.
Damage Mechanism of Cu6Sn5 Intermetallics Due to Cyclic Polymorphic Transitions
Authors: Zhang Zhihao , Wei Cunwei , Cao Huijun , Zhang Ye
Published: November 2019

The formation of high-melting-point Cu6Sn5 interconnections is crucial to overcome the collapse of Sn-based micro-bumps and produce reliable intermetallic interconnections in three-dimensional (3D) package. However, because of the multiple reflows in 3D package manufacturing, Cu6Sn5 interconnections will experience the cyclic polymorphic transitions in the solid state. The repeated and abrupt change in the Cu6Sn5 lattice due to the cyclic polymorphic transitions can cause extreme strain oscillations, producing damages at the surface and in the interior of the Cu6Sn5 matrix. Moreover, because of the polymorphic-transition-induced grain splitting and superstructure phase formation, the reliability of Cu6Sn5 interconnections will thus face great challenges in 3D package. In addition, the Cu6Sn5 polymorphic transition is structure-dependent, and the η′↔η polymorphic transition will occur at the surface while the η′↔ηs↔η polymorphic transition will occur in the deep matrix. Our results can provide in-depth understandings of structural evolution and damage mechanism of Cu6Sn5 interconnections in real 3D package manufacturing.
Efficacy and Safety of Immunotherapy and Standard of Care in High-Grade Gliomas: A Systematic Review and Meta-analysis
Authors: Zhang Shengnan , Xu Libo , Chen Guanyu , Liu Jiangmin , Wang Qian , Hu Xindan , Wen Naiyan , Liu Xiaomin , Peng Xinyu , Fan Lei , Guo Baofeng , Zhang Ling
Published: November 2019

BACKGROUND: Immunotherapy combined with standard of care (SOC) is often used for high-grade glioma (HGG). There are few comparisons of immunotherapy with SOC treatment or without SOC treatment (IMT) versus SOC. It is important to understand what interventions exist and their relative effectivenesses.
METHODS: The Cochrane Library, Embase, Medline, and the Web of Science Core Collection were systematically searched by two librarians. Retrieved hits were screened for inclusion. Subgroup analysis was used to examine the main factors associated with overall survival (OS) and progression-free survival (PFS), which were used as primary endpoints to assess the efficacy and safety of IMT. This study was registered with PROSPERO, number CRD42019112356.
RESULTS: The search yielded 2,315 results, of which 11 met the eligibility criteria. We identified 6 publications through exploration. Compared to SOC alone, IMT including viral therapy (VT) and dendritic cell vaccination improved the OS (HR = 0.55, 95% CI 0.42-0.72; p < 0.0001) and PFS (HR = 0.67, 95% CI 0.53-0.84; p = 0.0005).
CONCLUSIONS: We found that IMT in the era of TMZ has an improved effectiveness over SOC. Our findings support the use of immunotherapy for brain tumors to improve HGG outcomes.
A description of Surgical counting safety practices among operating room nurses and midwives in Rwanda
Authors: Mukantwari Joselyne , Omondi Lilian , Ntakirutimana Christian , Nyirasafari Emerthe
Published: November 2019

Background : The retained surgical item is a critical double burden to the patients and their families. One way of minimizing the risks of this critical burden is the surgical counting process which is costless, effective and preventive method. The present study aimed to determine the knowledge and practice towards surgical counting among operating room nurses and midwives at referral teaching hospitals in Rwanda. Methods: A descriptive cross-sectional study was conducted at four referral teaching hospitals on 160 randomly selected nurses and midwives working in the operating rooms. Nurses and midwives working in OR reported their knowledge and practices in surgical counting exercise using a self-administered questionnaire. A checklist was used by the researchers to observe the compliance with surgical count policy in the OR. Data were entered in Statistical Package for Social Sciences (SPSS version 21.0) for analysis. A correlation between knowledge and practices and association between demographic characteristics with knowledge and practices were tested in this study. The ethical principles were valued. Results: Out of 156 participants who responded to this study, the majority were females (62.8%), Married (70.5%), 30-39years old (53.8%), advanced diploma (82.1%) and with clinical experience below 6 years (52.5%). The majority (78.2%) had good knowledge of surgical count but the majority reported the poor practices (57.8%, n=89). Compared to self reported practices, the observation reports of 35 cases revealed very poor performance. Being female and 1-3 years experience in OR are factors for performing surgical counting practices (OR:3.030562;p≤0.027); and (OR; 9.215279;p ≤0.002) respectively). Conclusion : The surgical count practices were self-reported and observed at low level. The experience and female gender was associated with the practices towards surgical count safety. Others barriers that may hinder the practices were not explored in this study and recommended for further research. Increasing a number of specialized perioperative nurses in OR and in service training and policy implementation follow up may improve Surgical count safety practices. Key words: Surgical count, Operating room, Practice and Referral hospital
Correlation between expression of XB130, AKT and prognosis in non-small cell lung cancer patients
Authors: Chen Ling , Zhou Xinyi , Han Zenglei , Gai Kai , Liu Yang , Guo Chengye , Zhang Tenglong
Published: November 2019

Objective To examine XB130 and AKT expression levels in the pathological tissues of non-small cell lung cancer (NSCLC) followed by analysis of their relationship with other common prognostic indicators.Methods A retrospective analysis of the clinical and pathological characteristics of 120 NSCLC subjects from August 1, 2014 to August 1, 2015 was conducted. The expression of XB130 and AKT was detected by immunohistochemistry. Correlation analysis of XB130 with various other factors was analyzed by the Chi-squared test. Relationship between XB130, AKT and patient overall survival (OS), as well as progression-free survival (PFS) was examined using Cox analysis.Results The XB130 expression was significantly correlated to tumor differentiation (P = 0.004), T staging (P = 0.045), lymphatic metastasis (P = 0.028), and AKT expression (P = 0.043). Univariate analysis of the Cox proportional hazard model revealed that high XB130 expression, lymphatic metastasis, T staging, and high AKT expression were adverse prognostic factors for NSCLC (P < 0.05). Besides, the multivariate analysis demonstrated that high XB130 expression, lymph node metastasis, and high AKT expression were the independent prognostic factors (P < 0.05).Conclusion XB130, AKT, and lymph node metastasis are independent risk factors for NSCLC prognosis. XB130 might affect patient prognosis through AKT. XB130 may be a prognostic marker for the survival and a candidate for the treatment of NSCLC, with potential therapeutic prospects.
Association of HLA-DRB1 and -DQ Alleles and Haplotypes with Type 1 Diabetes in Jordanians
Authors: Khdair Sawsan I. , Jarrar Wassan , Jarrar Yazun Bashir , Bataineh Safa’a , Al-Khaldi Omar
Published: November 2019

Background:

The Human Leukocyte Antigen (HLA) class II genes, particularly the HLADR
and -DQ loci, have been shown to play a crucial role in Type 1 Diabetes (T1D) development.

Objective:

This study is the first to examine the contribution of the HLA-DR/DQ alleles and haplotypes
to T1D susceptibility in Jordanians.

Methods:

Polymerase chain reaction sequence-specific primers (PCR-SSP) were used to genotype 41
Jordanian healthy controls and 50 insulin-dependent diabetes mellitus (IDDM) patients.

Results:

The following alleles were found to be significant high risk alleles in T1D Jordanian patients:
DRB1*04 (OR=3.95, p<0.001), DRB1*0301(OR=5.27, p<0.001), DQA1*0301 (OR=5.67, p<0.001),
DQA1*0501(OR=3.18, p=0.002), DQB1*0201(OR=2.18, p=0.03), DQB1*0302 (OR=5.67, p<0.001).
However, Jordanians harboring the DRB1*0701 (OR=0.37, p=0.01), DRB1*1101 (OR=0.2, p=0.01),
DQA1*0505 (OR=0.31, p=0.02), DQA1*0103 (OR=0.33, p=0.04), DQA1*0201 (OR=0.45, p=0.04),
DQB1*0301 (OR=0.23, p=0.001), DQB1*0501 (OR=0.18, p=0.009) alleles had a significantly lower
risk of developing T1D.

Conclusion:

A strong positive association of DRB1*04-DQA1*0301-DQBl*0302 (OR=5.67,
p<0.001) and DRB1*0301-DQA1*0501-DQB1*0201 (OR=6.24, p<0.001) putative haplotypes with
IDDM was evident in Jordanian IDDM patients whereas DRB1*1101-DQA1*0505- DQB1*0301
(OR=0.23, p=0.03) was shown to have a protective role against T1D in Jordanians. Our findings show
that specific HLA class II alleles and haplotypes are significantly associated with susceptibility to T1D
in Jordanians.
Спектроскопические исследования изменений во вторичной структуре белков дентинной и десневой жидкостей по данным синхротронной ИК микроскопии
Authors: Середин П.В. , Голощапов Д.Л. , Ипполитов Ю.А. , Vongsvivut Jitraporn (Pimm)
Published: November 2019

На основе данных ИК спектромикроскопии с использованием синхротронного излучения проведено исследование вторичной структуры белков дентинной и десневой жидкостей человека при развитии кариозного процесса в глубоких тканях дентина. Показано, что изменение формы профиля полосы Амид I в области 1700-1605 cm-1 связано как с изменением соотношения интегральных интенсивностей вторичных структур alpha-cпираль и beta-лист, так и положением компонент beta-витки и beta-лист в спектре. Установлено, что величина соотношения alpha-спираль/beta-лист как для дентинной, так и десневой жидкостей лежит ниже порогового уровня, при котором наблюдаются значительные изменения во вторичной структуре белков биологических жидкостей и однозначно свидетельствует о развитии патологии в твердой ткани. Обнаруженные нами особенности в профиле полосы Амид I биологических жидкостей ротовой полости совместно со спектральными маркерами развития кариозного процесса в дентине являются достоверными спектроскопическими сигнатурами патологии и могут быть детектированы с использованием десневой жидкости. Ключевые слова: ИК микроскопия, синхротронное излучение, кариес дентина, спектроскопические сигнатуры патологических процессов.
Рентгенолюминесценция толстых пленок оксида цинка
Authors: Веневцев И.Д. , Родный П.А. , Муслимов А.Э. , Каневский В.М. , Бабаев В.А. , Исмаилов А.М.
Published: November 2019

Studies of thick films (approximately 30 μm) of undoped zinc oxide on sapphire substrate obtained by magnetron sputtering method with the use of an uncooled target were conducted. The structural and luminescent properties of the initial films and films that underwent additional recrystallization annealing in the air were investigated. The time and temperature dependent characteristics of the samples were considered. It was shown that annealing in air leads to an improvement in the structural, optical, and luminescent properties of the obtained film.
Identification of Type 2 Diabetes Management Mobile App Features and Engagement Strategies: Modified Delphi Approach (Preprint)
Authors: Alenazi Hanan A , Jamal Amr , Batais Mohammed A
Published: November 2019

BACKGROUND

Diabetes is a significant public health issue. Saudi Arabia has the highest prevalence of type 2 diabetes mellitus (T2DM) in the Arab world. Currently, it affects 31.6% of the general population, and the prevalence of T2DM is predicted to rise to 45.36% by 2030. Mobile health (mHealth) offers improved and cost-effective care to people with T2DM. However, the efficiency of engagement strategies and features of this technology need to be reviewed and standardized according to stakeholder and expert perspectives.

OBJECTIVE

The main objective of this study was to identify the most agreed-upon features for T2DM self-management mobile apps; the secondary objective was to identify the most agreed-upon strategies that prompt users to use these apps.

METHODS

In this study, a 4-round modified Delphi method was applied by experts in the domain of diabetes care.

RESULTS

In total, 11 experts with a mean age of 47.09 years (SD 11.70) consented to participate in the study. Overall, 36 app features were generated. The group of experts displayed weak agreement in their ranking of intervention components (Kendall W=0.275; P<.001). The top 5 features included insulin dose adjustment according to carbohydrate counting and blood glucose readings (5.36), alerting a caregiver of abnormal or critical readings (6.09), nutrition education (12.45), contacts for guidance if required (12.64), and offering patient-specific education tailored to the user’s goals, needs, and blood glucose readings (12.90). In total, 21 engagement strategies were generated. Overall, the experts showed a moderate degree of consensus in their strategy rankings (Kendall W=0.454; P<.001). The top 5 engagement strategies included a user-friendly design (educational and age-appropriate design; 2.82), a free app (3.73), allowing the user to communicate or send information/data to a health care provider (HCP; 5.36), HCPs prescribing the mobile app in the clinic and asking about patients’ app use compliance during clinical visits (6.91), and flexibility and customization (7.91).

CONCLUSIONS

This is the first study in the region consisting of a local panel of experts from the diabetes field gathering together. We used an iterative process to combine the experts’ opinions into a group consensus. The results of this study could thus be useful for health app developers and HCPs and inform future decision making on the topic.
Un desarrollo preocupante: sobre una tendencia reciente en el control constitucional de leyes penales
Authors: Grez Hidalgo Pablo , Wilenmann von Bernath Javier
Published: November 2019

The paper criticizes recent case law by the Chilean Constitutional Court regarding probation granting. It contains criticism of the two substantive (and incompatible) reasoning lines developed by the Court, the type of institutional orientation that the generation of those two lines supposes and, especially, the institutional understanding and consequences expressed by these decisions.
Déficits en la medición del miedo al delito en Chile
Authors: Galleguillos Agurto Sebastián
Published: November 2019

The purpose of this paper is to identify a series of conceptual and methodological difficulties in Chilean research on crime fear. In order to carry out the aforementioned, the introduction includes a section regarding the main dimensions of crime fear, in order to describe the problems that comparative literature has detected on the traditional way of measuring said phenomenon. The document ends by outlining suggestions for future research in the Chilean context.
Георгий Феодосьевич Вороной (1868--1908)
Authors: Долбилин Николай Петрович
Published: November 2019

Данная статья посвящена 150-летию со дня рождения выдающегося российского математика Георгия Феодосьевича Вороного.
Uso de Laboratórios Remotos no Brasil: uma revisão sistemática
Authors: Tulha Carinna Nunes , Carvalho Marco Antonio Garcia de , Coluci Vitor Rafael
Published: November 2019

Laboratórios remotos são ferramentas computacionais de apoio à educação consolidadas na literatura. Esta ferramenta possibilita a realização de atividades práticas via internet. Neste trabalho, realizou-se uma revisão sistemática, visando verificar o estado da arte atual da utilização dos laboratórios remotos na educação brasileira. O levantamento de estudos foi realizado em bases interdisciplinares de dados, devido ao caráter educacional e computacional da pesquisa. No total foram encontrados 23 artigos, sendo identificado dois possíveis focos descritivos, (i) técnicos, incluindo desenvolvimento e arquitetura dos experimento, ou (ii) didático, descrevendo atividades e avaliações em sala de aula. Os experimentos remotos encontrados são voltados a disciplinas da área de STEM (acrônimo em inglês para Ciências, Tecnologia e Engenharia). Também foi possível notar que, apesar de adaptáveis a diferentes níveis educacionais, há tendência de validação desta ferramenta no ensino superior.
Resumos de Teses
Authors: Gomes Raquel Salcedo
Published: November 2019

Teses homologadas entre maio e agosto de 2019.