bluuebunny/crossref_metadata_2025 huggingface dataset:
Penyuluhan Tentang Menyikapi Pandemi Corona Dengan Hidup Sehat Dan Makanan Bergizi
Authors: Aprilia Anissa , Shafariyah Aras , Elmariah Elmariah , F Lilis Cindy , Ariani Niken Dwi
Published: October 2021

Kegiatan Pengabdian Kepada Masyarakat, Mahasiswa ini bertujuan untuk memberikan informasi dan semangat di masa pandemi ini supaya tidak lupa untuk tetap menjaga pola hidup sehat dengan memakan makanan bergizi di lingkup anggota Masyarakat terutama anak remaja yang beralamat di Jln.Achmad Family No.42 RT 02/06 Gandul, Cinere, Depok. Hasil dari kegiatan tersebut adalah para peserta menjadi lebih mengerti akan pentingnya menjaga pola makan dalam kehidupan sehari-hari di masa pandemi untuk tetap mempertahankan imun tubuh dan mencegah virus masuk kedalam tubuh dengan mudah.Kata Kunci: Pendidikan, KesehatanThis Student Community Service activity aims to provide information and enthusiasm during this pandemic so that you don’t forget to maintain a healthy lifestyle by eating nutritious food among community members, especially teenagers, whose address is Jln. Achmad Family No. 42 RT. 02/06 Gandul, Cinere, Depok. The result of this activity was that the participants became more aware of the importance of maintaining a diet in daily life during a pandemic to maintain the body’s immune system and prevent viruses from entering the body easily.Keywords: Education, Health
VECTORS OF DEVELOPMENT OF EDUCATIONAL AND METHODOLOGICAL COMPETENCE OF THE MODERN TEACHER IN THE CONDITIONS OF MODERNIZATION OF VOCATIONAL EDUCATION OF UKRAINE
Authors: Shevchuk Svitlana , Kulishov Volodymyr , Shchypska Tetiana
Published: October 2021

The modern model of socio-economic development of Ukraine must meet an effective system of vocational and professional higher education, which can quickly adapt to market demands and provide training for skilled workers who are able to be competitive in the existing socio-economic space.. In recent years, a change in the educational paradigm is taking place in the state: from information-cognitive, inherent in industrial society, to personal-activity, based on a competency-based approach to the educational process, characteristic of the post-industrial, information society. Educational practice objectively needs to make a particular student the main figure in the educational process, thus focusing the activities of teachers of vocational education on the personification of the process of professional training. Significant changes in society, social life, the productive sector of the economy and the sphere of state services necessitate the training of a pedagogical worker with a fundamentally new type of thinking. An employee who is ready to carry out innovative pedagogical and scientific-methodical activities, professionally competent, who is able to perform constructive actions in various situations of a professional nature and carry out educational and methodological activities at a high scientific level in accordance with modern educational requirements. The article presents the main approaches to the development of professional competence of a teacher of the system of vocational and professional higher education. One of the leading components of professional development of a teacher is his ability to modern educational and methodological activities, which involves designing classes based on a competency approach, the use of innovative educational technologies, the introduction of integrated learning in the system of vocational education.
Els escarabeoïdeus (Coleoptera, Scarabaeoidea) de l’Àfrica paleàrtica dipositats al Museu de Ciències Naturals de Barcelona
Authors: Batet-Muñoz J. , Brañas N. , Masó G. , Viñolas A. , Caballero-López B.
Published: October 2021

We provide a detailed list of the 182 taxa and 2,836 specimens of Scarabaeoidea (families Geotrupidae, Glaphyridae, Hybosoridae, Lucanidae, Scarabaeidae and Trogidae) from Palaearctic Africa. All information associated with each specimen is now available in the MCNB open collections and GBIF platform. Reference is also provided regarding the historical context in which the collection began and the main collectors who made it possible.

Data published through GBIF (Doi: 10.15468/dl.3rbjve)
ДРАМА Б. ШОУ «СВЯТА ІОАННА» ЯК ХУДОЖНЄ ВТІЛЕННЯ КОНЦЕПЦІЇ «НОВОЇ ЖІНКИ»
Authors: Карпіна Олена , Молька Наталя
Published: October 2021

Предметом даного дослідження стала драма Б. Шоу «Свята Іоанна». У роботі відзначається історичний контекст виникнення документальної драми, спрямованої на відродження демократичного руху в суспільстві, в умовах якого виникає необхідність звернення до жіночих персоналій, які вплинули на розвиток історичних подій. Визначено основні проблеми, пов’язані з недостатньо освітленим питанням ролі жінок в історичному процесі. Охарактеризована новаторська ідея Б. Шоу, яка полягає у формуванні концепції «нової жінки», в рамках якої жінка відноситься не тільки до вирішення побутових питань, а й чий голос повинен враховуватися в суспільному розвитку. В роботі визначені причини, за якими драматург відносить Жанну д’Арк до святих. Б. Шоу розглядає Жанну як героя, до якого світ не готовий. У висновку підкреслюється, що Жанна д’Арк являє собою образ жінок, яким не дозволялося переходити за область чітко обмежених сфер діяльності.
Modernist Influences in Churchill Weavers Textiles: 1922-1949
Authors: Broomfield Sarah Stopenhagen
Published: October 2021

“Modernist Influences in Churchill Weavers Textiles: 1922-1949” is an interdisciplinary study of the Berea, Kentucky, handweaving production center, Churchill Weavers, which operated from 1922 to 2007. It documents craft production from Kentucky’s Appalachian foothills that exhibited a fusion of traditional and modern craft practices while incorporating a modernist design style. The study highlights traditional hand weaving production with a modern look from the interwar period, coming from a location not typically thought of as a center for innovation, national, or international movements. The study examines textiles designed by Eleanor Churchill in the beginning decades of the company and woven on flyshuttle handlooms designed and built by David Carroll Churchill. Taking into account the cosmopolitan influences from India, Sweden, and the German Bauhaus school, the research documents a craft production center that provided economic development in a rural community. The project highlights the unique role that Churchill Weavers played in American handweaving and craft history by moving textiles into the modern industrial age while maintaining an artisanal practice. The study notes the influences that early twentieth-century feminism and cultural pluralism played in the economic development work of craft promotion, and how Churchill Weavers’ founders navigated those influences in their economic enterprise. The Churchills were settler-colonialists whose commitment to artisanal work made a long-lasting contribution to the lives of many in Berea, Kentucky. The author is a Kentucky Community Scholar and a former designer at the company with multiple exposures to the archives of the Churchill Weavers company’s rich material culture.
The souls of the dead: images woven in women’s clothing of the Jalq’a cultural area (south-central Bolivia)
Authors: Cereceda Verónica
Published: October 2021

Both their style of dress and, particularly, the textile designs that distinguish them already at a first look have made three ethnic groups stand out in south-central Bolivia: “Llameros,” “Yamparas,” and “Jalq’as” inhabit neighboring lands in the departments of Potos and Chuquisaca. Ethno-historians and archaeologists define the pre-conquest and early colonial past of these contemporary identities as only two groups: populations belonging to the great ayllus of the high plains, Norpotosinos (Llameros) and Yamparas, with their two political centers: janan (upper) in Jatun Yampara and urin (lower) in Quila Quila.

Today the panorama is more complex: the two Yamparas centers split and each sub-region has its own diacritical definitions. An analysis of the transformations in the textile patterns (pallays in Quechua), over the past one hundred years permits us, nonetheless, to perceive today a new path of integration by means of profound levels of visual-plastic language where only a joint reading permits an integral vision of the contemporary indigenous cosmos.

The European structuring of the world in three parts, imposed by Christianization, though reinterpreted, has given expression to these three regional identities: the Llameros designs and style of dress are Gloria or heaven, the Yamparas are this Earth of ours, those of the Jalq’a belong to Hell. How does the unity of plastic and sensual identity arise to permit the reading of three such different appearances as a single whole, the universe? That is the topic of this talk.
Efecto del Triticum Vulgare intravaginal, en el tratamiento del síndrome genitourinario de la menopausia, en mujeres del Quindío, 2017-2019.
Authors: Espitia De La Hoz Franklin José
Published: October 2021

Introducción: el principal objetivo terapéutico, en el síndrome genitourinario de la menopausia, es aliviar los síntomas. Objetivo: determinar el efecto del Triticum vulgare, en el tratamiento del síndrome genitourinario de la menopausia. Métodos: estudio observacional; incluyó mujeres en posmenopausia, sexualmente activas con diagnóstico de síndrome genitourinario de la menopausia; entre 2017 y 2019, en Armenia (Colombia). El efecto se evaluó mediante la observación de la evolución de la mejoría y desaparición de los síntomas del síndrome genitourinario de la menopausia y con la puntuación del índice de función sexual femenino. Se midió la aparición de reacciones adversas. Se utilizó dosis de 200 mg vía intravaginal diario por cinco semanas, luego cada tercer día por cinco semanas y finalmente una vez a la semana por cinco semanas; se completaron quince semanas de seguimiento. Resultados: el estudio incluyó 109 mujeres, con edad media de 58,29 ± 3,17 años. Los síntomas vaginales fueron los más frecuentes, en el 69,72% de las participantes. Al final del estudio el positivo efecto fue notorio al observarse mejoras significativas en los síntomas, con una disminución de la severidad del 91,74%, y en la mediana de los síntomas (4 vs. 1, p=0,001). En el índice de función sexual femenino la puntuación final alcanzó 27,16 ± 5,29 con una elevación media de 3,57 ±1,18 puntos (p=0,001). No se presentaron reacciones adversas. Conclusión: el Triticum Vulgare intravaginal, mostró un efecto positivo en el tratamiento del síndrome genitourinario de la menopausia. Se requieren ensayos clínicos aleatorizados controlados, sobre su eficacia y seguridad en poblaciones más numerosas.
Suplementos deportivos: ¿Cómo definimos a estos productos?
Authors: Muñoz-Maldonado Gerardo Enrique , Ochoa-Ahmed Fernando Alberto , Díaz-Ochoa Eduardo Alejandro , Ramírez-Orozco Ricardo Ernesto , Gómez Renaud5 Víctor Manuel
Published: October 2021

Existe una gran variedad de suplementos alimenticios, los cuales pueden ser utilizados con diversas finalidades, por lo que la categorización de los suplementos deportivos ha sido compleja y hasta el día de hoy insatisfactoria en el área científica e incluso legal, por lo que es importante intentar contribuir a la descripción de una definición de suplemento deportivo para su contextualización en México y de esta forma homologar la terminología en futuros trabajos de investigación científica en diversas áreas.
Theoretical and methodological approaches to assessment of industrial enterprises’ investment attractiveness
Authors: Bieloborodova Mariia
Published: October 2021

The purpose of the research is to expand theoretical and methodological approaches to assessing the investment attractiveness of industrial enterprises. Modern methodological approaches to the issue were analyzed to highlight their advantages and disadvantages and provide a common toolkit of each approach. Based on the results of a critical analysis of the relevant scientific literature, a classification of existing theoretical and methodological approaches is proposed with the allocation of four classification groups which are combined, market, strategic and financial accounting approaches. The article substantiates the expediency of using an integrated rating approach to assessing the investment attractiveness of industrial enterprises. This approach is based on the involvement of a wide range of statistical, financial and mathematical tools, as well as on the study of the impact on the investment attractiveness of "hard" external and "soft" internal factors with ranking their significance for the resulting indicator. The proposed approach involves the assessment of a two-level system of factors, the first level of which includes factors characterizing the efficiency of activities, and the second level includes indicators of financial stability and solvency of industrial enterprises. The advantages of this approach are the attraction of versatile coefficients that allow the most complete characterization of the investment attractiveness of a particular enterprise. The results of the research create the necessary basis for further systematic study of the problem of estimation investment attractiveness in the context of the most complete realization of the economic potential of industrial enterprises, determining the investment potential of territories, regions and industries. Together with the qualitative indicators of the significance of factors based on expert assessments, the proposed approach allows determining ways to increase the level of the industrial enterprises’ investment attractiveness.
ВИХОВНИЙ ПОТЕНЦІАЛ СУЧАСНОЇ ЗАРУБІЖНОЇ ЛІТЕРАТУРИ У ФОРМУВАННІ ЗАГАЛЬНОЛЮДСЬКОЇ ЦІННОСТІ – ЛЮБОВІ
Authors: Андреєва О.
Published: October 2021

У статті обґрунтована ідея, що художня література наділена великою силою виховного потенціалу. Література є одним із найголовніших чинників впливу на формування та виховання загальнолюдських цінностей та якостей людини у будь-якому віці. Особливий інтерес представляє проблема виховання за допомогою сучасної зарубіжної літератури такої загальнолюдської цінності, як любов. У статті розглянуто цю цінність як зацікавленість та прагнення до культивації у своїй свідомості таких чеснот, як добро, духовність, творення, прийняття себе та іншої людини. Література – це віддзеркалення дійсності, особливостей суспільства країни, мислення та звичок народів. Письменник, митець споглядає та відтворює дійсність середовища через призму свого сприйняття у творі. Літературний твір – це засіб комунікації автора, представника суспільства, народу окремої країни з читачем. Значна роль в процесі формування студентської молоді належить засобам художньої літератури. Високий виховний потенціал художньої літератури та сучасної зарубіжної літератури обумовлений специфікою її змісту, засвоєння якого розвивається особистістю та збагачує її внутрішній світ знаннями духовних цінностей, переживаннями їх смислової значущості. Таким чином, ми, занурюючись у світ, що його зображує митець, сприймаємо, відчуваємо емоції, думки, настрої, тенденції та проблеми розвитку або деградації людини, представника суспільства, нації, носія менталітету. Мета статті – дослідити виховний потенціал сучасної зарубіжної літератури щодо виховання любові.
The Role of Procalcitonin as a Prognostic Variable in Ovarian Cancer Patients at Dr. Soetomo General Hospital Surabaya
Authors: Rasjad Irma Savitri , Tjokroprawiro Brahmana Askandar
Published: October 2021

Background: Procalcitonin (PCT) is a pro-hormone calcitonin that is strongly associated with bacterial infections, especially bacteremia. High serum PCT levels have been correlated with Lung cancer, colorectal cancer, thyroid cancer, and tumors of neuroendocrine. Studies on the role of PCT in ovarian tumors are still limited. This study aims to evaluate the role of PCT as a prognostic variable to determine the effectiveness of diagnostics in predicting ovarian cancer progression and metastasis.Methods: This was a descriptive analytic study with a cross sectional design, conducted in Dr. Soetomo General Hospital Surabaya from July until October 2019. The subject selection used total quota sampling with inclusion criteria of female aged >12 or already menstruating, undergoing surgical removal of ovarian tumors either cystic or solid, with risk malignancy index (RMI) of >200, and with imaging results of suggestive ovarian malignancy. The data were analyzed descriptively using Chi-square test (α <0.05) and receiver operating characteristic (ROC) curve analysis.Results: There were 36 study subjects; 38.9% of them are 40-49 years old; 77.8% have malignant tumors; and 22.2% of them have benign tumors with epithelial histopathology of 78.5% and nonepithelial of 21.4%. The optimal cut-off for PCT levels in ovarian tumors is 0.07 ng/ml with a 57.1% sensitivity and 87.5% specificity. There was a significant correlation between levels of PCT and ovarian tumors based on tumor types, postoperative tumor residues, and stages (p <0.05). There was no significant correlation between PCT levels and histopathological types and tumor grade.Conclusions: Procalcitonin can be used as a prognostic variable to determine disease progression in ovarian tumors, especially in ovarian cancer.
Profile of Ovarian Cancer Patients In Mangusada Badung Regional Public Hospital
Authors: Kamajaya I Gusti Ngurah Agung Trisnu , Brahmantara Bagus Ngurah , Wirawan AA Ngurah Agung Putra
Published: October 2021

Background: Ovarian cancer is still one of the neoplasms within the gynecology scope. Besides, World Health Organization (WHO) states that ovarian cancer ranks fourth cancer in women with the lowest five-year survival rate (43%). Thus, this research aims to recognize the risk factors in patients with ovarian cancer and the commonly found characteristic.Methods: This cross-sectional observational research on 29 women diagnosed with ovarian cancer observed the age, parity, body mass index (BMI), contraception, character, and stadium. The medical record samples based on patients’ registers were obtained from the Obstetrics and Gynecologic Polyclinic in Mangusada Badung Regional Public Hospital in the January–December 2019 period, and the result data were distributed using contingency tables. Results: The data dominantly diagnosed ovarian cancer, with age distribution 51-60 years (34.5%), 44.8% with obesity, 44.8% nullipara, without a history of contraceptive use, menarche within 12 years old (41.4%), diagnosed stage IIIC (42.3%), and with serous epithelial tumor subclassification (65.5%).Conclusions: Predominant ovarian cancer is found at a late stage. The most common risk factors of developing ovarian cancer, including the age of 51–60, obesity, menarche within 12 years old, and no history of hormonal contraceptive use, are consistent with this research hypothesis about risk factors dominantly found in patients with ovarian cancer
Uji Efektivitas Daun Maja (Aegle marmelos) Sebagai Bioinsektisida Hama Plutella xylostella pada Tanaman Brokoli (Brassica oleracea var. italica)
Authors: Azizah Silvia Fitrotul , Laili Saimul , Lisminingsih Ratna Djuniwati
Published: October 2021

Indonesia has many insecticide producing plants that can be used as a control of plant pests.. Fermentation of squeeze maja leaves is suspected to be used as an herbal insecticide. Broccoli as a vegetable plant brassicacea tribe, one of the pests destroying broccoli plants is the caterpillar Plutella xylostella. The purpose ofthis research is to find out the effectiveness of fermentation of maja leaves as a pest of Plutella xylostella. Experimental research method is done using randomized design group (RDG) with 5 treatment concentrations sprayed fermentation maja leaves that is P0 = control (0%), P1 (25%), P2 (50%), P3  (75%), P4 (100%) and 4 repeats. Data from the analysis using Anova. The results showed Fhit > F(0.05) which is 11.12 > 3.26 there is a significant influence. But for the treatment of group Fhit < F(0.05) which is 1.15 < 3.49. The temporary conclusion of fermentation spraying of maja leaves has an effect  on the mortality of the pest Plutella xylostella, but has no significant effect on the treatment of the group.Keywords: Maja Leaf Fermentation Solution, Herbal Insecticide, Plutella xylostella Pest  ABSTRAKIndonesia mempunyai banyak tumbuhan penghasil insektisida yang dapat dimanfaatkan sebagai mengendalikan hama tanaman. Fermentasi perasan daun maja diduga dapat digunakan sebagai bahan insektisida herbal. Brokoli sebagai tanaman sayuran suku brassicacea, salah satu hama perusak tanaman brokoli adalah ulat Plutella xylostella. Tujuan penelitian ini untuk mengetahui efektivitas fermentasi perasan daun maja sebagai mengendali hama Plutella xylostella.Metode penelitian dilakakuan secara eksperimental menggunakan Rancangan Acak Kelompok (RAK) dengan 5 perlakuan konsentrasi yang disemprot fermentasi perasan daun maja yaitu P0 = kontrol (0%), P1 (25%), P2 (50%), P3 (75%), P4 (100%) dan 4 kali ulangan. Data hasil penelitian dianalisis menggunakan Anova. Hasil penelitian menunjukkan Fhit > F(0,05) yaitu 11.12 > 3.26 terdapat pengaruh yang signifikan. Tetapi untuk perlakuan kelompok Fhit < F(0.05) yaitu 1.15 < 3,49. Kesimpulan sementara penyemprotan fermentasi perasan daun maja berpengaruh terhadap mortalitas hama Plutella xylostella, tetapi tidak berpengaruh secara signifikan terhadap perlakuan kelompok.Kata kunci : Larutan Fermentasi Daun Maja, Insektisida Herbal, Hama Plutella xylostella
InterPepRank: Assessment of Docked Peptide Conformations by a Deep Graph Network
Authors: Johansson-Åkhe Isak , Mirabello Claudio , Wallner Björn
Published: October 2021

Peptide-protein interactions between a smaller or disordered peptide stretch and a folded receptor make up a large part of all protein-protein interactions. A common approach for modeling such interactions is to exhaustively sample the conformational space by fast-Fourier-transform docking, and then refine a top percentage of decoys. Commonly, methods capable of ranking the decoys for selection fast enough for larger scale studies rely on first-principle energy terms such as electrostatics, Van der Waals forces, or on pre-calculated statistical potentials. We present InterPepRank for peptide-protein complex scoring and ranking. InterPepRank is a machine learning-based method which encodes the structure of the complex as a graph; with physical pairwise interactions as edges and evolutionary and sequence features as nodes. The graph network is trained to predict the LRMSD of decoys by using edge-conditioned graph convolutions on a large set of peptide-protein complex decoys. InterPepRank is tested on a massive independent test set with no targets sharing CATH annotation nor 30% sequence identity with any target in training or validation data. On this set, InterPepRank has a median AUC of 0.86 for finding coarse peptide-protein complexes with LRMSD < 4Å. This is an improvement compared to other state-of-the-art ranking methods that have a median AUC between 0.65 and 0.79. When included as a selection-method for selecting decoys for refinement in a previously established peptide docking pipeline, InterPepRank improves the number of medium and high quality models produced by 80% and 40%, respectively. The InterPepRank program as well as all scripts for reproducing and retraining it are available from: http://wallnerlab.org/InterPepRank.
Preparation and Application in Water Treatment of Magnetic Biochar
Authors: Zhao Qingshuang , Xu Ting , Song Xueping , Nie Shuangxi , Choi Sun-Eun , Si Chuanling
Published: October 2021

This paper reviews the preparation of magnetic biochar and its application in wastewater treatment, and briefly discusses the adsorption mechanism of biochar to remove pollutants and the modification methods of biochar. Due to the good physical and chemical properties of biochar, including its rough porous structure, it has been widely used to absorb pollutants from water. Magnetic biochar is commonly prepared by combining biochar with magnetic material. The biochar is endowed with the characteristics of the magnetic material, which could effectively solve the problems of difficult recovery and easy loss of adsorbent in water treatment. Magnetic biochar with high carbon content, large specific surface area, magnetic separation, and other excellent properties, has become a hot research topic in recent years. The preparation methods and application properties of magnetic biochar are reviewed. The future research directions of magnetic biochar are put forward to provide directions for further research and application of magnetic biochar materials.
Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner
Authors: Trelford Charles B. , Di Guglielmo Gianni M.
Published: October 2021

The mechanism(s) in which transforming growth factor beta 1 (TGFβ) modulates autophagy in cancer remain unclear. Here, we characterized the TGFβ signaling pathways that induce autophagy in non-small cell lung cancer cells, using cells lines stably expressing GFP-LC3-RFP-LC3ΔG constructs that measure autophagic flux. We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. Further analysis revealed that the canonical Smad4 pathway and the non-canonical TGFβ activated kinase 1/tumor necrosis factor receptor-associated factor 6/P38 mitogen activated protein kinase (TAK1-TRAF6-P38 MAPK) pathway are important for TGFβ1-induced autophagy. The TAK1-TRAF6-P38 MAPK pathway was essential for downregulating mTOR S2448 phosphorylation, ULK1 S555 phosphorylation and autophagosome formation. Furthermore, although siRNA-mediated Smad4 silencing did not alter mTOR-dependent ULK1 S757 phosphorylation, it did reduce AMPK-dependent ULK1 S555 phosphorylation and autophagosome formation. Additionally, Smad4 silencing and inhibiting the TAK1-TRAF6-P38 MAPK pathway decreased autophagosome-lysosome co-localization in the presence of TGFβ. Our results suggest that the Smad4 and TAK1-TRAF6-P38 MAPK signaling pathways are essential for TGFβ-induced autophagy and provide specific targets for the inhibition of TGFβ in tumor cells that utilize autophagy in their epithelial-mesenchymal transition program.
Ginsenoside Rg3 Promotes Cell Growth Through Activation of mTORC1
Authors: Liu Wei , Zhang Sheng-Xiong , Ai Bo , Pan Hua-Feng , Zhang Dan , Jiang Yu , Hu Lei-Hao , Sun Ling-Ling , Chen Zhe-Sheng , Lin Li-Zhu
Published: October 2021

Graphical Abstract

Ginsenoside Rg3 promotes cell growth through activation of mTORC1 and increasing mitochondrial biogenesis.
Dopant-Free Hole Transporting Material Based on Nonconjugated Adamantane for High-Performance Perovskite Solar Cells
Authors: Fan Dongyu , Zhang Ren , Li Yuheng , Shan Chengwei , Li Wenhui , Wang Yunhao , Xu Feiyang , Fan Hua , Sun Zonghao , Li Xuehui , Zhao Mengshuai , Kyaw Aung Ko Ko , Li Gongqiang , Wang Jianpu , Huang Wei
Published: October 2021

A new dopant-free hole transporting material (HTM) 4′,4‴,4‴'',4‴''''-(adamantane-1,3,5,7-tetrayl)tetrakis(N,N-bis(4-methoxyphenyl)-[1,1′-biphenyl]-4-amine) (Ad-Ph-OMeTAD) (named FDY for short), which consists of a nonconjugated 3D bulky caged adamantane (Ad) as the core, triphenyl amines as side arms, and phenyl units as a linking bridge, is synthesized and applied in an inverted planar perovskite solar cell (PSC). As a result, the champion device with FDY as HTM yields an impressive power of conversion efficiency (PCE) of 18.69%, with JSC = 22.42 mA cm−2, VOC = 1.05 V, and FF = 79.31% under standard AM 1.5G illumination, which is ca. 20% higher than that of the device based on PEDOT:PSS (only 15.41%). Notably, the stability of PSC based on FDY is much better than that of devices based on PEDOT:PSS, and the corresponding devices retain over 90% of their initial PCEs after storing for 60 days in a nitrogen glove box without any encapsulation. Even when stored in an open air condition with 50–60% relative humidity for 188 h, the retained PCE is still over 81% of its initial one. All these results demonstrate that the new design strategy by combing the bulky and nonconjugated (aliphatic) adamantane unit as the core and triphenyl amines as side arms can efficiently develop highly efficient HTMs for PSCs, which is different from the traditional way based on conjugated backbones, and it may open a new way for scientists to design small-molecule HTMs for PSCs.
Spontaneous Remission After a Hypercalcemic Crisis Caused by an Intracystic Hemorrhage of Bilateral Parathyroid Adenomas: A Case Report and Literature Review
Authors: Liu Yaoxia , Li Jianwei , Liu Hui , Yang Han , Qiao Jingtao , Wei Tao , Wang Tao , Yu Yerong
Published: October 2021

Background

Hyperparathyroidism is a common cause of hypercalcemia; however, spontaneous remission after a hypercalcemic crisis caused by an intracystic hemorrhage of parathyroid adenomas is very rare. The question, then, is “What is the best treatment strategy for this type of case?”

Method

A 47-year-old male patient with primary hyperparathyroidism and a hypercalcemic crisis is reported. Hypercalcemia was spontaneously relieved thereafter. Postoperative paraffin pathology results indicated an intracystic hemorrhage of bilateral parathyroid adenomas.

Results

After the case report, a literature review is also included to summarize the clinical features of this patient and to provide special reference for clinical diagnosis and treatment of similar cases.

Conclusions

The choice of surgical timing for such cases can be made based on the comprehensive consideration of clinical symptoms and changes in parathyroid function.
Rapid Power Compensation-Based VSC-HVDC Control Strategy for Low-Frequency Oscillation Suppression of the Island Power System
Authors: Lv Haipeng , Abuduwayiti Xiwang , Meng Lingpeng , Shi Cunjin
Published: October 2021

Owing to the increased proportion of new energy power generation, such as wind power and photovoltaics, connected to the island grid, the system powered by the voltage source converter-based HVDC (VSC-HVDC) is prone to oscillate or even lose stability when disrupted. In this study, considering the rapid power compensation (RPC), an active power control strategy has been suggested for the receiving-end converter station of VSC-HVDC that could efficiently suppress the low-frequency oscillation of the island power system. First, the mechanism of VSC-HVDC inhibiting low-frequency oscillation of the island grid is analyzed in this study, and then, it theoretically determines that the damping capacity and inertia level of the rapid power compensation control strategy are stronger than those of conventional droop control and inertia control. Second, the receiving-end converter station switches from the RPC mode to droop control in order to allow the system to have a smooth recovery from the steady-state operation in the later stage of oscillation suppression. Moreover, detailed control logic and state-switching strategies have been designed. Finally, the simulation reflects that the proposed control strategy has a stronger oscillation suppression ability, allowing it to obtain rapid suppression of low-frequency oscillation.
Risk Assessment of Dam-Breach Flood Under Extreme Storm Events
Authors: Lin Xiajing , Huang Guohe , Wang Guoqing , Yan Denghua , Zhou Xiong
Published: October 2021

In recent years, as a result of increasingly intensive rainfall events, the associated water erosion and corrosion have led to the increase in breach risk of aging dams in the United States. In this study, a hydrodynamic model was used to the inundation simulation under three hypothetical extreme precipitation-induced homogeneous concrete dam-breach scenarios. All hydraulic variables, including water depth, flow velocity, and flood arriving time over separated nine cross-sections in the Catawba River, were calculated. The hypothetical simulation results illustrate that the impact of Hurricane Florence’s rainfall is far more severe over the downstream of hydraulic facilities than that of the Once-in-a-century storm rainfall event. Although Hurricane Florence’s rainfall observed in Wilmington had not historically happened near the MI Dam site, the river basin has a higher probability to be attacked by such storm rainfall if more extreme weather events would be generated under future warming conditions. Besides, the time for floodwaters to reach cross-section 6 under the Hurricane Gustav scenario is shorter than that under the Once-in-a-century rainfall scenario, making the downstream be inundated in short minutes. Since the probability can be quantitatively evaluated, it is of great worth assessing the risk of dam-break floods in coastal cities where human lives are at a vulnerable stage.
Grazing Effects on Mongolian Steppe Vegetation—A Systematic Review of Local Literature
Authors: Munkhzul Oyunbileg , Oyundelger Khurelpurev , Narantuya Naidan , Tuvshintogtokh Indree , Oyuntsetseg Batlai , Wesche Karsten , Jäschke Yun
Published: October 2021

The Mongolian steppes with a long history of nomadic pastoralism cover a large area of the Palaearctic steppe biome and are still relatively intact. As livestock number has increased over the last two decades, grazing has been considered as the main reason of pasture degradation. However, the impact of grazing on vegetation dynamics, and its interaction with climate, is still not clear. We reviewed 44 publications in Mongolian language, covering 109 sites in five main steppe types, i.e., desert, dry, meadow, mountain, and high mountain steppe, with a mean annual precipitation and temperature range from 120 to 370 mm and from −6 to +5°C, respectively. We calculated relative changes in vegetation cover, species richness, and aboveground biomass from heavily grazed with respect to lightly/non-grazed conditions. Multiple linear regression models were used to test the impact of environmental factors, i.e., mean annual precipitation, coefficient of variation for precipitation, mean annual temperature and elevation. Grazing had a stronger effect on the vegetation of dry, desert and high mountain steppes, whereas its effect was less pronounced in the meadow and mountain steppes with mesic climate and high productivity. Vegetation cover, species richness and aboveground biomass were reduced by heavy grazing in the dry, desert and high mountain steppes. In the meadow steppes, grazing reduced vegetation cover, but increased richness and had nearly no effect on biomass. In the mountain steppe, richness and cover were not affected, but biomass was reduced by heavy grazing. Additionally, grazing effects on biomass tended to be more pronounced at sites with higher amounts of annual precipitation, and effects on cover changed from negative to positive as elevation increased. In conclusion, grazing effects in Mongolian steppes are overall negative in desert, dry and high mountain steppes, but no or even positive effects are found in meadow and mountain steppes. Especially, heavy grazing showed a detrimental effect on all vegetation variables in desert steppes, indicating the existence of combined pressure of climate and grazing in arid habitats, making them potentially sensitive to overgrazing and climate change. Grassland conservation and management should consider characteristics of different steppe types and give importance to local environmental conditions.
A Core Response to the CDX2 Homeoprotein During Development and in Pathologies
Authors: Gourain Victor , Duluc Isabelle , Domon-Dell Claire , Freund Jean-Noël
Published: October 2021

Whether a gene involved in distinct tissue or cell functions exerts a core of common molecular activities is a relevant topic in evolutionary, developmental, and pathological perspectives. Here, we addressed this question by focusing on the transcription factor and regulator of chromatin accessibility encoded by the Cdx2 homeobox gene that plays important functions during embryonic development and in adult diseases. By integrating RNAseq data in mouse embryogenesis, we unveiled a core set of common genes whose expression is responsive to the CDX2 homeoprotein during trophectoderm formation, posterior body elongation and intestinal specification. ChIPseq data analysis also identified a set of common chromosomal regions targeted by CDX2 at these three developmental steps. The transcriptional core set of genes was then validated with transgenic mouse models of loss or gain of function of Cdx2. Finally, based on human cancer data, we highlight the relevance of these results by displaying a significant number of human orthologous genes to the core set of mouse CDX2-responsive genes exhibiting an altered expression along with CDX2 in human malignancies.
Single-Cell Transcriptome Profiling Identifies Phagocytosis-Related Dual-Feature Cells in A Model of Acute Otitis Media in Rats
Authors: Rao Yufang , Zhong Dalin , Qiu Ke , Cheng Danni , Li Li , Zhang Yi , Mao Minzi , Pang Wendu , Li Daibo , Song Yao , Li Junhong , Dong Yijun , Zhang Wei , Yu Haopeng , Ren Jianjun , Zhao Yu
Published: October 2021

Background

The molecular mechanisms of acute otitis media (AOM) development, and the intercellular crosstalk within the multicellular ecosystem of AOM, are not clear.

Methods

We established a model of AOM in rats (with normal rats as controls) and undertook single-cell RNA sequencing (scRNA-seq) for the middle-ear mucosa (MEM). Cell clustering and trajectory analyses were undertaken using Seurat and Monocle 2 packages in R software. Pathway analyses were done by gene set enrichment analysis (GSEA). Cell–cell interactions were inferred by CellChat. Cell scores were calculated to identify cells with dual-feature.

Results

A total of 7023 cells from three samples of inflamed MEM and 5258 cells from three samples of healthy MEM underwent scRNA-seq, which identified 20 cell clusters belonging to eight major cell types. After exposure to lipopolysaccharide, the MEM underwent significant conversion of cell types characterized by rapid infiltration of macrophages and neutrophils. M2 macrophages seemed to play a key part in inflammatory intercellular crosstalk, which facilitated the maintenance and proliferation of macrophages, cell chemotaxis, and regulation of the proinflammatory activities of cytokines. Three rare cell clusters with phagocytosis-related dual-feature were also identified. They coexisted with professional phagocytes in the MEM, and displayed distinct immunoregulatory functions by maintaining a normal immune microenvironment or influencing inflammation progression.

Conclusions

Macrophages might be the “master” initiators and regulators of the inflammatory response of the MEM to external stimuli. And their functions are fulfilled by a specific polarization status (M2) and sophisticated intercellular crosstalk via certain signaling pathways. Besides, the coexistence of professional phagocytes and non-professional phagocytes as well as their interplay in the MEM provides new clues for deciphering the underlying pathogenic mechanisms of AOM.
Knowledge Co-construction by Citizens and Researchers to Create a SNAPSHOT of the Marine Environment During and After the Covid-19 Lockdown
Authors: Giuffredi Rita , Criscuolo Laura , De Lazzari Amelia , Fanelli Giovanni , Giordano Raffaele , Petrocelli Antonella , Portacci Giuseppe , Pugnetti Alessandra , L’Astorina Alba
Published: October 2021

Lockdown measures adopted in Italy to contain the diffusion of Covid-19 altered many variables influencing the anthropogenic pressure on marine ecosystems. Public reactions included surprise at how quickly changes in human activity seemingly improved natural recovery and, at the same time, a generalized anxiety to restart economic activities. In this situation several Institutions from the Italian National Research Council (CNR) made a joint effort to quantify the effects of the unprecedented experimental conditions induced by the reduction of many anthropogenic pressures. The resulting project was conceived with a holistic, interdisciplinary approach, geared to combine scientific, economic and cultural observations to promote collective actions suitable to the governance of socio-ecological systems, reconciling respect for the environment with human activities and wellbeing, and thus grounding an ethical approach to marine resources. Alongside collecting considerable amount of scientific observations, the project is working to complement samplings and analyses with the non-formal knowledge carried by the inhabitants of a set of coastal zones, thus enriching the generated knowledge and widening inclusion and pluralism in defining the challenges at stake; simultaneously it focuses on stimulating a reflection in the research community over the process of knowledge co-construction, its meaning, role and responsibility in the societal context. After a brief contextualization of this activity, we present here the perspective adopted by researchers to build a responsible marine research plan, inclusive on the grounds of both involved actors and knowledge sources. We comment the process- and community-related features, explore limits and opportunities, and propose a set of recommendations, based on a preliminary review of our experience and oriented to promote the development of a shared Ocean ethics.
The Therapeutic Intervention of Sex Steroid Hormones for Sarcopenia
Authors: Huang Le-Tian , Wang Jia-He
Published: October 2021

Sarcopenia, characterized by the excessive loss of skeletal muscle mass, strength, and function, is associated with the overall poor muscle performance status of the elderly, and occurs more frequently in those with chronic diseases. The causes of sarcopenia are multifactorial due to the inherent relationship between muscles and molecular mechanisms, such as mitochondrial function, inflammatory pathways, and circulating hormones. Age-related changes in sex steroid hormone concentrations, including testosterone, estrogen, progesterone, and their precursors and derivatives, are an important aspect of the pathogenesis of sarcopenia. In this review, we provide an understanding of the treatment of sarcopenia through the regulation of sex steroid hormones. The potential benefits and future research emphasis of each sex steroid hormone therapeutic intervention (testosterone, SARMs, estrogen, SERMs, DHEA, and progesterone) for sarcopenia are discussed. Enhanced understanding of the role of sex steroid hormones in the treatment for sarcopenia could lead to the development of hormone therapeutic approaches in combination with specific exercise and nutrition regimens.
OneHealth Approaches Contribute Towards Antimicrobial Resistance: Malaysian Perspective
Authors: Mariappan Vanitha , Vellasamy Kumutha Malar , Mohamad Nor Alia , Subramaniam Sreeramanan , Vadivelu Jamuna
Published: October 2021

On a global scale, antimicrobial resistance (AMR) is recognized as a One Health challenge due to the continual and increased development and distribution of resistant microbes and genes among humans, animals, and the environment. These sectors contribute to the increase in AMR, as antibiotics are widely used in healthcare to treat or prevent bacterial infection; as growth enhancers, therapeutics and metaphylactics in animal husbandry; and transmitted in the environment through irrigation using wastewater or inappropriate disposal and treatment of human and agricultural waste. However, there is a major drawback in terms of the lack of research assessing the coexistence of AMR in these sectors. Extensive research highlighted food–animal manufacture structures that are likely to harbor reservoirs or promote transmission of AMR, in addition to increasing human colonization with AMR commensal bacteria. Numerous antibiotic stewardship policies have been designed and implemented in medical practices and animal husbandry in high- and middle-income countries. However, research concentrating on high-income settings, attitudes, emotions, and beliefs on the utilization of antimicrobials remain underexplored in lower- and middle-income countries such as Malaysia. Microbiological, epidemiological, and social science exploration are required at community and farming across the One Health range to fill huge gaps in information and knowledge of AMR. Manipulating human activities and character associated with antibiotics is a multifaceted progression that includes elements like knowledge, social behavior, attitudes, approaches, social standards, socioeconomic settings, peer pressure, experiences, and biophysical environment. Therefore, understanding these aspects in the utilization of antimicrobial drugs among the different sectors is essential to develop and implement policies to curb AMR development and transmission that overarch all sectors within the One Health consortium in Malaysia.
“Kambakutaisoto” and Emotional Instability Associated With Premenstrual Syndrome
Authors: Shiota Atsuko , Shime Chika , Nakai Kyoko , Kageyama Mitsuru
Published: October 2021

Many women suffer from premenstrual syndrome (PMS), which can be considered a modern illness in this busy society; mental symptoms, such as irritability, often affect the surroundings and result in loss of self-confidence. The symptoms of PMS are diverse, and it is often difficult to treat psychiatric and social symptoms with low-dose estrogen progestin combination drug (LEP) alone. Selective serotonin reuptake inhibitors (SSRIs) are also effective; however, many are unable to take them owing to their side effects. “Kambakutaisoto” is a Kampo medicine consisting of “jujube,” “licorice,” and “wheat,” which is often described as “food”; however, it is highly effective in treating emotional instability attributed to PMS in sensitive young women. There are many reports on the effects of kambakutaisoto; the molecular nutritional findings of kambakutaisoto, which has dramatic effects despite its mild composition of crude drugs, have also been reported, suggesting an association with premenstrual exacerbation of functional hypoglycemia. A narrative review of its clinical effects on PMS and the results of molecular nutrition studies was performed.
H2AFZ Is a Prognostic Biomarker Correlated to TP53 Mutation and Immune Infiltration in Hepatocellular Carcinoma
Authors: Dong Mingwei , Chen Jing , Deng Yiran , Zhang Danying , Dong Ling , Sun Dalong
Published: October 2021

H2A family member Z (H2AFZ) is a highly conserved gene encoding H2A.Z.1, an isoform of histone variant H2A.Z, and is implicated in cancer. In this study, we report that overexpression of H2AFZ is associated with tumor malignancy and poor prognosis in HCC patients. Functional network analysis suggested that H2AFZ mainly regulates cell cycle signaling and DNA replication via pathways involving several cancer-related kinases and transcription factor E2F1. Further studies revealed that H2AFZ overexpression is regulated by TP53 mutation and led to an attenuation of rapid proliferation phenotype and aggressive behavior in HCC cells. Moreover, we found that H2AFZ was related to immune infiltrations and was co-expressed with immune checkpoint genes, including CD274 (PD-L1), CTLA-4, HAVCR2 (TIM3), LAG3, PDCD1 (PD-1), and TIGIT (VSIG9) in HCC, indicating that H2AFZ-overexpressed HCC patients may be sensitive to immune checkpoint blockades (ICBs). Integrated analysis suggested that H2AFZhigh/TP53mut patients had the shortest OS and PFS time, but most likely to respond to ICBs. These findings indicate that the H2AFZ possesses potential value as a novel prognostic indicator for HCC patients and is correlated with immune infiltration in HCC, laying a foundation for future study of HCC investigation and intervention.