bluuebunny/crossref_metadata_2025 huggingface dataset:
Sport and Politics in Africa
Authors: Sikes Michelle
Published: April 2019

African politics have always had a significant effect on sport, despite cherished mantras that sport and politics are mutually exclusive. Conversely, sport has played a meaningful role in the politics of African nations, from nation-building to widening foreign policy options, to making national alliances of countries that may not have otherwise supported each other, particularly with respect to the anti-apartheid struggle. Twentieth-century African politics have been a laboratory for the testing and ultimate debunking of the long-standing notion that African sport (or any human activity) exists in a vacuum, apart from the political realities of the culture within which it exists.
Constructions of Social Justice, Marginalization, and Belonging
Authors: Li Yongjian , Dervin Fred
Published: April 2019

The theme of social justice appears to be central in education research. A polysemic and sometimes empty notion, social justice can be defined, constructed, and used in different ways, which makes it a problematic notion to work with intra- and interculturally. Global education research has often relied on constructions of the notion as they have been “done” in the West, leaving very little space to constructions from peripheries. This problematic and somewhat biased approach often leads to research that ignores local contexts and local ways of “discoursing” about social justice. Although some countries are said to be better at social justice in education (e.g., top performers in the OECD PISA studies), there is a need to examine critically and reflexively how it is “done” in different contexts (“winners” and “losers” of international rankings) on macro- and micro-levels. Two different educational utopias, China and Finland, are used to illustrate the different constructions of social justice, and more specifically marginalization and belonging in relation to migrant students—an omnipresent figure in world education—in the two countries. A call for learning with each other about social justice, and questioning too easily accepted definitions and/or formulas, is made.
Classroom Ethics
Authors: Sockett Hugh
Published: April 2019

Classroom ethics is the responsibility of both the teacher and the learner. The teacher is an autonomous moral agent; and the child-learner is in the process of becoming one, so classroom ethics cannot be seen as managed by the teacher, or salient sources of moral agency will be neglected. Definitions of both “classroom” and “ethics” situate an inquiry focused on American schools. The child’s ethical experience of a classroom can be found in friendship and trustworthiness, or the lack of either, and in children’s ethical transgressions, cheating and bullying. Classrooms are not always benign environments and can be places of fear and loneliness. How teachers respond to these four elements of the child’s classroom experience is central to their moral agency as teachers. The quality of ethics in a classroom is central to, not exclusively determined by, the four elements in moral agency—namely, ethical sensitivity, including race, prejudice, and diverse classrooms; ethical judgment and religious issues; ethical motivation and a plea for altruism, yielding teachers’ ethical actions. Classroom ethics are not acquired by teachers as moral techniques. The basis for classroom quality lies in teachers and student teachers having a strong moral identity, presently being crowded out by testing, management theory such that teachers are unable to grow their moral autonomy as professionals through the onerous and threatening activities of educational systems, their administrators and politicians.
Use of Qualitative Methods in Evaluation Studies
Authors: Ranganathan Namita , Wadhwa Toolika
Published: April 2019

Evaluation studies typically comprise research endeavors that are undertaken to investigate and gauge the effectiveness of a program, an institution, or individuals working in educational contexts, such as teachers, students, administrators, and other stakeholders in education. Usually, research studies in this genre use empirical methods to evaluate educational practices and systems. Alternatively, they may take up theoretical reflections on new policies, programs, and systems. An evaluation study requires a rigorous design and method of assessment to focus on the specific context and set of issues that it targets. In general, research studies that attempt to evaluate a program, an individual, or an institution place emphasis on checking their efficacy. They do not seek to find explanations that have led to the level of efficacy that the variables under study may have achieved. Thus, quite often, they are contested as not being full-fledged research.

Evaluation studies use a variety of methods. The choice of method depends on the area of study as well as the research questions. An evaluation study may thus fall within the qualitative or quantitative paradigms. Often, a mixed method approach is used. The purpose of the study plays a significant role in deciding the method of inquiry and analysis. Establishing the probability, plausibility, and adequacy of the program can be some of the main aims of evaluation studies. This implies as well that the programs, institutions, or individuals under study would have an impact on the course and direction of future programs and practices. An evaluation study is thus of vital importance to ensure that appropriate decisions can be made about efficacy, transferability to different contexts, and difficulties and challenges to be faced in subsequent applications.

Evaluation studies in India have been done in a vast range of areas that include program evaluation, impact studies, evaluations of specific interventions, performance outcome assessments, and the like. Some examples of studies undertaken by the government and the development sector in this regard are the following: assessment of interventions for adolescence education; impact studies of interventions, programs, and policies launched for education of minorities, including girls; and evaluation of performance outcomes stemming from programs for education of the marginalized.

The key challenges in evaluation studies are to gather accurate data in order to establish reliable outcomes, to establish clear relationships between the outcomes and the interventions being studied, and to safeguard against researcher bias.
Women's Legal Rights in Africa
Authors: Bond Johanna
Published: April 2019

In the colonial and postcolonial period, African women have advocated for legal reforms that would improve the status of women across the continent. During the colonial period, European common and civil law systems greatly influenced African indigenous legal systems and further entrenched patriarchal aspects of the law. In the years since independence, women’s rights advocates have fought, with varying degrees of success, for women’s equality within the constitution, the family, the political arena, property rights, rights to inheritance, rights to be free from gender-based violence, rights to control their reproductive lives and health, rights to education, and many other aspects of life. Legal developments at the international, national, and local levels reflect the efforts of countless African women’s rights activists to improve the status of women within the region.
Bayesian Vector Autoregressions: Estimation
Authors: Miranda-Agrippino Silvia , Ricco Giovanni
Published: April 2019

Vector autoregressions (VARs) are linear multivariate time-series models able to capture the joint dynamics of multiple time series. Bayesian inference treats the VAR parameters as random variables, and it provides a framework to estimate “posterior” probability distribution of the location of the model parameters by combining information provided by a sample of observed data and prior information derived from a variety of sources, such as other macro or micro datasets, theoretical models, other macroeconomic phenomena, or introspection.

In empirical work in economics and finance, informative prior probability distributions are often adopted. These are intended to summarize stylized representations of the data generating process. For example, “Minnesota” priors, one of the most commonly adopted macroeconomic priors for the VAR coefficients, express the belief that an independent random-walk model for each variable in the system is a reasonable “center” for the beliefs about their time-series behavior. Other commonly adopted priors, the “single-unit-root” and the “sum-of-coefficients” priors are used to enforce beliefs about relations among the VAR coefficients, such as for example the existence of co-integrating relationships among variables, or of independent unit-roots.

Priors for macroeconomic variables are often adopted as “conjugate prior distributions”—that is, distributions that yields a posterior distribution in the same family as the prior p.d.f.—in the form of Normal-Inverse-Wishart distributions that are conjugate prior for the likelihood of a VAR with normally distributed disturbances. Conjugate priors allow direct sampling from the posterior distribution and fast estimation. When this is not possible, numerical techniques such as Gibbs and Metropolis-Hastings sampling algorithms are adopted.

Bayesian techniques allow for the estimation of an ever-expanding class of sophisticated autoregressive models that includes conventional fixed-parameters VAR models; Large VARs incorporating hundreds of variables; Panel VARs, that permit analyzing the joint dynamics of multiple time series of heterogeneous and interacting units. And VAR models that relax the assumption of fixed coefficients, such as time-varying parameters, threshold, and Markov-switching VARs.
Equality of Opportunity in Health and Healthcare
Authors: Jusot Florence , Tubeuf Sandy
Published: April 2019

Recent developments in the analysis of inequality in health and healthcare have turned their interest into an explicit normative understanding of the sources of inequalities that calls upon the concept of equality of opportunity. According to this concept, some sources of inequality are more objectionable than others and could represent priorities for policies aiming to reduce inequality in healthcare use, access, or health status.

Equality of opportunity draws a distinction between “legitimate” and “illegitimate” sources of inequality. While legitimate sources of differences can be attributed to the consequences of individual effort (i.e. determinants within the individual’s control), illegitimate sources of differences are related to circumstances (i.e. determinants beyond the individual’s responsibility).

The study of inequality of opportunity is rooted in social justice research, and the last decade has seen a rapid growth in empirical work using this literature at the core of its approach in both developed and developing countries. Empirical research on inequality of opportunity in health and healthcare is mainly driven by data availability. Most studies in adult populations are based on data from European countries, especially from the UK, while studies analyzing inequalities of opportunity among children are usually based on data from low- or middle-income countries and focus on children under five years old.

Regarding the choice of circumstances, most studies have considered social background to be an illegitimate source of inequality in health and healthcare. Geographical dimensions have also been taken into account, but to a lesser extent, and more frequently in studies focusing on children or those based on data from countries outside Europe. Regarding effort variables or legitimate sources of health inequality, there is wide use of smoking-related variables.

Regardless of the population, health outcome, and circumstances considered, scholars have provided evidence of illegitimate inequality in health and healthcare. Studies on inequality of opportunity in healthcare are mainly found in children population; this emphasizes the need to tackle inequality as early as possible.
Health Insurance and Labor Supply
Authors: Colman Gregory , Dave Dhaval , Lenhart Otto
Published: April 2019

Health insurance depends on labor market activity more in the U.S. than in any other high-income country. A majority of the population are insured through an employer (known as employer-sponsored insurance or ESI), benefiting from the risk pooling and economies of scale available to group insurance plans. Some workers may therefore be reluctant to leave a job for fear of losing such low-cost insurance, a tendency known as “job lock,” or may switch jobs or work more hours merely to obtain it, known as “job push.” Others obtain insurance through government programs for which eligibility depends on income. They too may adapt their work effort to remain eligible for insurance. Those without access to ESI or who are too young or earn too much to qualify for public coverage (Medicare and Medicaid) can buy insurance only in the individual or nongroup market, where prices are high and variable. Most studies using data from before the passage of the Patient Protection and Affordable Care Act (ACA) in 2010 support the prediction that ESI reduced job mobility, labor-force participation, retirement, and self-employment prior to the ACA, but find little effect on the labor supply of public insurance. The ACA profoundly changed the health insurance market in the U.S., removing restrictions on obtaining insurance from new employers or on the individual market and expanding Medicaid eligibility to previously ineligible adults. Research on the ACA, however, has not found substantial labor supply effects. These results may reflect that the reforms to the individual market mainly affected those who were previously uninsured rather than workers with ESI, that the theoretical labor market effects of expansions in public coverage are ambiguous, and that the effect would be found only among the relatively small number on the fringes of eligibility.
The Economics of Diet and Obesity: Public Policy
Authors: Etilé Fabrice
Published: April 2019

The rise in obesity and other food-related chronic diseases has prompted public-health officials of local communities, national governments, and international institutions to pay attention to the regulation of food supply and consumer behavior. A wide range of policy interventions has been proposed and tested since the early 21st century in various countries. The most prominent are food taxation, health education, nutritional labeling, behavioral interventions at point-of-decision, advertising, and regulations of food quality and trade. While the standard neoclassical approach to consumer rationality provides limited arguments in favor of public regulations, the recent development of behavioral economics research extends the scope of regulation to many marketing practices of the food industry. In addition, behavioral economics provides arguments in favor of taxation, easy-to-use front-of-pack labels, and the use of nudges for altering consumer choices. A selective but careful review of the empirical literature on taxation, labeling, and nudges suggests that a policy mixing these tools may produce some health benefits. More specifically, soft-drink taxation, front-of-pack labeling policies, regulations of marketing practices, and eating nudges based on affect or behavior manipulations are often effective methods for reducing unhealthy eating.

The economic research faces important challenges. First, the lack of a proper control group and exogenous sources of variations in policy variables make evaluation very difficult. Identification is challenging as well, with data covering short time periods over which markets are observed around slowly moving equilibria. In addition, truly exogenous supply or demand shocks are rare events. Second, structural models of consumer choices cannot provide accurate assessment of the welfare benefits of public policies because they consider perfectly rational agents and often ignore the dynamic aspects of food decisions, especially consumer concerns over health. Being able to obtain better welfare evaluation of policies is a priority. Third, there is a lack of research on the food industry response to public policies. Some studies implement empirical industrial organization models to infer the industry strategic reactions from market data. A fruitful avenue is to extend this approach to analyze other key dimensions of industrial strategies, especially decisions regarding the nutritional quality of food. Finally, the implementation of nutritional policies yields systemic consequences that may be underestimated. They give rise to conflicts between public health and trade objectives and alter the business models of the food sector. This may greatly limit the external validity of ex-ante empirical approaches. Future works may benefit from household-, firm-, and product-level data collected in rapidly developing economies where food markets are characterized by rapid transitions, the supply is often more volatile, and exogenous shocks occur more frequently.
Bayesian Vector Autoregressions: Applications
Authors: Miranda-Agrippino Silvia , Ricco Giovanni
Published: April 2019

Bayesian vector autoregressions (BVARs) are standard multivariate autoregressive models routinely used in empirical macroeconomics and finance for structural analysis, forecasting, and scenario analysis in an ever-growing number of applications.

A preeminent field of application of BVARs is forecasting. BVARs with informative priors have often proved to be superior tools compared to standard frequentist/flat-prior VARs. In fact, VARs are highly parametrized autoregressive models, whose number of parameters grows with the square of the number of variables times the number of lags included. Prior information, in the form of prior distributions on the model parameters, helps in forming sharper posterior distributions of parameters, conditional on an observed sample. Hence, BVARs can be effective in reducing parameters uncertainty and improving forecast accuracy compared to standard frequentist/flat-prior VARs.

This feature in particular has favored the use of Bayesian techniques to address “big data” problems, in what is arguably one of the most active frontiers in the BVAR literature. Large-information BVARs have in fact proven to be valuable tools to handle empirical analysis in data-rich environments.

BVARs are also routinely employed to produce conditional forecasts and scenario analysis. Of particular interest for policy institutions, these applications permit evaluating “counterfactual” time evolution of the variables of interests conditional on a pre-determined path for some other variables, such as the path of interest rates over a certain horizon.

The “structural interpretation” of estimated VARs as the data generating process of the observed data requires the adoption of strict “identifying restrictions.” From a Bayesian perspective, such restrictions can be seen as dogmatic prior beliefs about some regions of the parameter space that determine the contemporaneous interactions among variables and for which the data are uninformative. More generally, Bayesian techniques offer a framework for structural analysis through priors that incorporate uncertainty about the identifying assumptions themselves.
LaBeouf, Rönkkö & Turner, Digital Remix, and Group Authorship
Authors: Corsa Andrew J
Published: April 2019

I argue that sometimes a group can author a work of art without the work being either co-authored or multiply-authored. Sometimes the group, itself, is an author, rather than any of its members alone or together. I argue that when a group is an author like this, it has mental properties that no individual member of the group possesses. For example, we can consider the groups that authored digital remixes based on a film titled #INTRODUCTIONS created by the artists LaBeouf, Rönkkö & Turner. YouTubers posted their digital remixes online, and the question is: Who authored those remixes? I contend that many digital remixes are authored by groups that are capable of cognition.
A Tour of the Senses
Authors: Korsmeyer Carolyn
Published: April 2019

Traditionally, the bodily senses of smell, taste, and touch have been designated ‘nonaesthetic’ senses and their objects considered unsuited to be fashioned into works of fine art. Recent innovations in the art world, however, have introduced scents, tastes, and tactile qualities into gallery exhibits, movements that, at least superficially, appear parallel to philosophical revaluations of the senses. This paper investigates the aesthetic scope of the five external senses, addressing some standard arguments about the limits of the ‘lower’ senses. I defend the artistic scope of the bodily senses by appealing to cross-modal perception and to the sensuous aspects of appreciative emotional responses to art.
When Constitutional Theories Migrate: A Case Study
Authors: Geiringer Claudia
Published: April 2019

The last decade or so has witnessed a burgeoning of literature on the role of cross-jurisdictional influences in the design (as well as subsequent interpretation) of national constitutions. The consensus emerging from that literature is that transnational borrowing in the course of constitution making is both inevitable and impossible. In a globalized world, those involved in the design of a new constitution naturally look beyond their borders for inspiration. Borrowing is thus endemic. But borrowing, in any true sense, is also impossible because in the process of migration, constitutional ideas must be de- and then recontextualized in order to fit them for the new legal system.

What, though, if the object of transnational influence is not a constitutional text or an institutional mechanism but, rather, a scholarly theory? That is the question addressed by this Article. Specifically, the Article examines the intriguing (and little known) story of how John Hart Ely’s representation-reinforcing theory of (American) constitutional interpretation was transformed into a blueprint for the design of the New Zealand Bill of Rights Act. It suggests that Ely’s journey to the South Pacific has the potential to illuminate both the study of constitutional migration generally and, more specifically, the linkages between comparative law and constitutional theory.
Establishing Absolute Lymphocyte Count Thresholds for Further Review of Peripheral Blood Lymphocytosis to Judiciously Screen for Monoclonal B-Cell Populations in Older Adults
Authors: Muscara Matthew J , Cook Benjamin A , Dhesi Mary S , Groo Stephen C , Andrews Jared M
Published: April 2019

Objectives

Lymphocytosis may represent either a lymphoproliferative disorder (LPD) or a reactive process. The absolute lymphocyte count (ALC) threshold for further evaluation of lymphocytosis is not well established.

Methods

We prospectively performed flow cytometry on blood samples from patients 50 years or older with ALCs of 4.0 × 109 cells/L or greater without a history of an LPD.

Results

Monoclonal B-cell populations were found in 34 (19.1%) of 178 cases, with incidence increasing with age. In patients younger than 75 years, no monoclonal B-cell population was identified in patients with ALCs less than 4.4 × 109 cells/L, while such clones were found below and above this threshold in patients 75 years and older.

Conclusions

These findings support a threshold for smear review and flow cytometry no lower than 4.4 × 109 cells/L in patients younger than 75 years and a threshold as low as 4.0 × 109 cells/L in patients 75 years and older.
Preference of Peponapis pruinosa (Hymenoptera: Apoidea) for Tilled Soils Regardless of Soil Management System
Authors: Skidmore Amanda R , Short Clancy A , Dills Chasity , Goodell Karen , Bessin Ricardo T
Published: April 2019

Concerns about global pollinator declines have placed a growing focus on understanding the impact of agriculture practices on valuable native pollinators in these systems. Cultivation practices such as tillage disturb agroecosystems and can have negative impacts on ground-nesting pollinators. The squash bee, Peponapis pruinosa (Say), is a ground-nesting specialist pollinator of Cucurbita (Cucurbitaceae) crops (i.e., pumpkins and squash) that often nests in agricultural fields and thus may be vulnerable to these practices. We investigated the impact of tillage on nesting behavior of P. pruinosa in plasticulture and strip-tilled squash systems. We used choice experiments to test nesting substrate preference and nesting success of caged P. pruinosa in two soil tillage systems: strip tillage and plasticulture. The strip tillage system comprised two tillage zones (strip-tilled row with no-till edges), and the plasticulture system comprised two tillage zones (plastic bed and conventional tillage edge). The results of our study indicate that P. pruinosa nesting density did not significantly differ between the strip tillage and plasticulture systems. Within each system, P. pruinosa preferred excavating nests in the most disturbed soil zones (strip-tilled row and conventionally tilled edge). In the strip tillage system, the strip-tilled row had significantly more nests than the no-till edge. Results of these studies suggest that soil tillage practices can influence P. pruinosa nesting choice and production practices should be considered when developing a pollinator protection plan.
Impact of recurrent mitral regurgitation after mitral valve repair for functional mitral regurgitation: long-term analysis of competing outcomes
Authors: Petrus Annelieke H J , Dekkers Olaf M , Tops Laurens F , Timmer Eva , Klautz Robert J M , Braun Jerry
Published: April 2019

Aims

Recurrent mitral regurgitation (MR) has been reported after mitral valve repair for functional MR. However, the impact of recurrent MR on long-term survival remains poorly defined. In the present study, mortality-adjusted recurrent MR rates, the clinical impact of recurrent MR and its determinants were studied in patients after mitral valve repair with revascularization for functional MR in the setting of ischaemic heart disease.

Methods and results

Long-term clinical and echocardiographic outcome was evaluated in 261 consecutive patients after restrictive mitral annuloplasty and revascularization for moderate to severe functional MR, between 2000 and 2014. The cumulative incidence of recurrent MR ≥ Grade 2, assessed by competing risk analysis, was 9.6 ± 1.8% at 1-year, 20.3 ± 2.5% at 5-year, and 27.6 ± 2.9% at 10-year follow-up. Cumulative survival was 85.8% [95% confidence interval (CI) 81.0–90.0] at 1-year, 67.3% (95% CI 61.1–72.6%) at 5-year, and 46.1% (95% CI 39.4–52.6%) at 10-year follow-up. Age, preoperative New York Heart Association Class III or IV, a history of renal failure, and recurrence of MR expressed as a time-dependent variable [HR 3.28 (1.87–5.75), P < 0.001], were independently associated with an increased mortality risk. Female gender, a history of ST-elevation myocardial infarction, a preoperative QRS duration ≥120 ms, a higher preoperative MR grade, and a higher indexed left ventricular end-systolic volume were independently associated with an increased likelihood of recurrent MR.

Conclusion

Mitral valve repair for functional ischaemic MR resulted in a low incidence of recurrent MR with favourable clinical outcome up to 10 years after surgery. Presence of recurrent MR at any moment after surgery proved to be independently associated with an increased risk for mortality.
Weaning of Children With Burn Injury by Noninvasive Ventilation: A Clinical Experience
Authors: Piastra Marco , Picconi Enzo , Morena Tony C , Brasili Luca , Pizza Alessandro , Luca Ersilia , Tortorolo Luca , De Luca Daniele , Cati Gabriele , Conti Giorgio , De Bellis Andrea
Published: April 2019

The aim of this study was to report the respiratory management of a cohort of infants admitted to a Pediatric Intensive Care Unit (PICU) over a 7-year period due to severe burn injury and the potential benefits of noninvasive ventilation (NIV). A retrospective review of all pediatric patients admitted to PICU between 2009 and 2016 was conducted. From 2009 to 2016, 118 infants and children with burn injury were admitted to our institution (median age 16 months [IQR = 12.2–20]); 51.7% of them had face burns, 37.3% underwent tracheal intubation, and 30.5% had a PICU stay greater than 7 days. Ventilated patients had a longer PICU stay (13 days [IQR = 8–26] vs 4.5 days [IQR = 2–13]). Both ventilation requirement and TBSA% correlated with PICU stay (r = .955, p < .0001 and r = .335, p = .002, respectively), while ventilation was best related in those >1 week (r = .964, p < .0001 for ventilation, and r = −.079, p = .680, for TBSA%). NIV was introduced in 10 patients, with the aim of shorten the invasive ventilation requirement. As evidenced in our work, mechanical ventilation is frequently needed in burned children admitted to PICU and it is one of the main factors influencing PICU length of stay. No difference was found in terms of PICU length of stay and invasive mechanical ventilation time between children who underwent NIV and children who did not, despite children who underwent NIV had a larger burn surface. NIV can possibly shorten the total invasive ventilation time and related complications.
Differential Interaction Strengths and Prey Preferences Across Larval Mosquito Ontogeny by a Cohabiting Predatory Midge
Authors: Cuthbert Ross N , Callaghan Amanda , Dick Jaimie T A
Published: April 2019

Understandings of natural enemy efficacy are reliant on robust quantifications of interaction strengths under context-dependencies. For medically important mosquitoes, rapid growth during aquatic larval stages could impede natural enemy impacts through size refuge effects. The identification of biocontrol agents which are unimpeded by ontogenic size variability of prey is therefore vital. We use functional response and prey preference experiments to examine the interaction strengths and selectivity traits of larvae of the cohabiting predatory midge Chaoborus flavicans (Meigen 1830) (Diptera: Chaoboridae) towards larval stages of the Culex pipiens (Diptera: Culicidae) mosquito complex. Moreover, we examine the influence of search area variation on selectivity traits, given its importance in consumer-resource interactions. Chaoborids were able to capture and consume mosquito prey across their larval ontogeny. When prey types were available individually, a destabilizing Type II functional response was exhibited towards late instar mosquito prey, whereas a more stabilizing Type III functional response was displayed towards early instars. Accordingly, search efficiencies were lowest towards early instar prey, whereas, conversely, maximum feeding rates were highest towards this smaller prey type. However, when the prey types were present simultaneously, C. flavicans exhibited a significant positive preference for late instar prey, irrespective of water volume. Our results identify larval chaoborids as efficacious natural enemies of mosquito prey, with which they frequently coexist in aquatic environments. In particular, an ability to prey on mosquitoes across their larval stages, coupled with a preference for late instar prey, could enable high population-level offtake rates and negate compensatory reductions in intraspecific competition through size refuge.
Preventable Cancer Burden Associated With Poor Diet in the United States
Authors: Zhang Fang Fang , Cudhea Frederick , Shan Zhilei , Michaud Dominique S , Imamura Fumiaki , Eom Heesun , Ruan Mengyuan , Rehm Colin D , Liu Junxiu , Du Mengxi , Kim David , Lizewski Lauren , Wilde Parke , Mozaffarian Dariush
Published: April 2019

Background

Diet is an important risk factor for cancer that is amenable to intervention. Estimating the cancer burden associated with diet informs evidence-based priorities for nutrition policies to reduce cancer burden in the United States.

Methods

Using a comparative risk assessment model that incorporated nationally representative data on dietary intake, national cancer incidence, and estimated associations of diet with cancer risk from meta-analyses of prospective cohort studies, we estimated the annual number and proportion of new cancer cases attributable to suboptimal intakes of seven dietary factors among US adults ages 20 years or older, and by population subgroups.

Results

An estimated 80 110 (95% uncertainty interval [UI] = 76 316 to 83 657) new cancer cases were attributable to suboptimal diet, accounting for 5.2% (95% UI = 5.0% to 5.5%) of all new cancer cases in 2015. Of these, 67 488 (95% UI = 63 583 to 70 978) and 4.4% (95% UI = 4.2% to 4.6%) were attributable to direct associations and 12 589 (95% UI = 12 156 to 13 038) and 0.82% (95% UI = 0.79% to 0.85%) to obesity-mediated associations. By cancer type, colorectal cancer had the highest number and proportion of diet-related cases (n = 52 225, 38.3%). By diet, low consumption of whole grains (n = 27 763, 1.8%) and dairy products (n = 17 692, 1.2%) and high intake of processed meats (n = 14 524, 1.0%) contributed to the highest burden. Men, middle-aged (45–64 years) and racial/ethnic minorities (non-Hispanic blacks, Hispanics, and others) had the highest proportion of diet-associated cancer burden than other age, sex, and race/ethnicity groups.

Conclusions

More than 80 000 new cancer cases are estimated to be associated with suboptimal diet among US adults in 2015, with middle-aged men and racial/ethnic minorities experiencing the largest proportion of diet-associated cancer burden in the United States.
Characteristics and preparation of the last-minute traveler: analysis of vaccine usage in the Global TravEpiNet Consortium
Authors: Yates Johnnie A , Rao Sowmya R , Walker Allison Taylor , Esposito Douglas H , Sotir Mark , LaRocque Regina C , Ryan Edward T ,   Global TravEpiNet Consortium, Abraham George M , Alvarez Salvador , Ansdell Vernon , Yates Johnnie A , Atkins Elisha H , Birich Holly K , Vitek Dagmar , Cahill John , Chen Lin , Connor Bradley A , Dismukes Roberta , Kozarsky Phyllis , Wu Henry , Dosunmu Ronke , Goad Jeffrey A , Mirzaian Edith , Agudelo Higuita Nelson Iván , Hess Karl , Hynes Noreen A , Jacquerioz Frederique , McLellan Susan , Katsolis Jenn , Kelly Paul , Knouse Mark , Lee Jennifer , Leung Daniel , Oladele Alawode , Demeke Hanna , Oladele Alawode , Otuata Althea , Pasinski Roger , Wheeler Amy E , Showler Adrienne , Coster Laura , Rosen Jessica , Schwartz Brian S , Stauffer William , Walker Patricia , Vinetz Joseph
Published: April 2019

Background

Last-minute travellers (LMTs) present challenges for health care providers because they may have insufficient time for recommended vaccinations or pre-travel preparation. Our objective was to obtain a better understanding of LMTs in order to help travel medicine providers develop improved strategies to decrease the number of LMTs and potentially reduce travel-related morbidity.

Methods

We defined LMTs as travellers with a departure date of 7 days or fewer from the medical encounter. We analysed the characteristics and health preparation of 12 494 LMTs who presented to a network of US clinical practices for pre-travel health advice between January 2009 and December 2015.

Results

LMTs comprised 16% of all travellers. More LMTs than non-LMTs travelled for business or to visit friends and relatives (VFR) (26% vs 16% and 15% vs 8%, respectively; P < 0.0001). More LMTs also travelled for longer than 1 month (27% vs 21%; P < 0.0001) and visited only urban areas (40% vs 29%; P < 0.0001). At least one travel vaccine was deferred by 18% of LMTs because of insufficient time before departure. Vaccines that required multiple vaccinations, such as Japanese encephalitis and rabies, were the most likely to be deferred because of time constraints.

Conclusion

Interventions to improve the timing of pre-travel health consultations should be developed, particularly for business and VFR travellers. Recently endorsed accelerated vaccine schedules for Japanese encephalitis and rabies may help some LMTs receive protection against these infections despite late presentation for pre-travel health care.
Reconceiving the Divine in Eliette Abécassis’ La répudiée
Authors: Bostow Raquelle K
Published: April 2019

Eliette Abécassis’ La répudiée (2000) narrates a rare story of female mystical practice in the face of her impending repudiation from a Hasidic community, which excludes women from intellectual engagement with religious texts. Set in the fictionalised neighbourhood of Meah Shearim in Jerusalem, the novel’s main character, Rachel, faces a divorce under the law of halakhah when she fails to become pregnant after ten years of marriage. Yet, throughout the novel, Rachel asserts her own individualised spiritual practice by locating the ‘divine’ within the love that she shares with her partner, placing her on the path of mysticism. To articulate Rachel’s intuition of the divine within human relationships, I rely on French author Hélène Cixous’ secularised notion of the juifemme: a woman who rewrites sacred texts, conceives of a God detached from dogmatic religion, and locates the divine within the other and the self.
Origin of the DAMPE 1.4 TeV peak
Authors: Chan Man Ho , Lee Chak Man
Published: April 2019

Recent accurate measurements of cosmic ray electron flux by the Dark Matter Particle Explorer (DAMPE) reveal a sharp peak structure near 1.4 TeV, which is difficult to explain by standard astrophysical processes. In this Letter, we propose a simple model that the enhanced dark matter annihilation via the e+e− channel and with the thermal relic annihilation cross-section around the current nearest black hole (A0620-00) can satisfactorily account for the sharp peak structure. The predicted dark matter mass is ∼1.5–3 TeV.
Robust Method for Detecting Convergent Shifts in Evolutionary Rates
Authors: Partha Raghavendran , Kowalczyk Amanda , Clark Nathan L , Chikina Maria
Published: April 2019

Identifying genomic elements underlying phenotypic adaptations is an important problem in evolutionary biology. Comparative analyses learning from convergent evolution of traits are gaining momentum in accurately detecting such elements. We previously developed a method for predicting phenotypic associations of genetic elements by contrasting patterns of sequence evolution in species showing a phenotype with those that do not. Using this method, we successfully demonstrated convergent evolutionary rate shifts in genetic elements associated with two phenotypic adaptations, namely the independent subterranean and marine transitions of terrestrial mammalian lineages. Our original method calculates gene-specific rates of evolution on branches of phylogenetic trees using linear regression. These rates represent the extent of sequence divergence on a branch after removing the expected divergence on the branch due to background factors. The rates calculated using this regression analysis exhibit an important statistical limitation, namely heteroscedasticity. We observe that the rates on branches that are longer on average show higher variance, and describe how this problem adversely affects the confidence with which we can make inferences about rate shifts. Using a combination of data transformation and weighted regression, we have developed an updated method that corrects this heteroscedasticity in the rates. We additionally illustrate the improved performance offered by the updated method at robust detection of convergent rate shifts in phylogenetic trees of protein-coding genes across mammals, as well as using simulated tree data sets. Overall, we present an important extension to our evolutionary-rates-based method that performs more robustly and consistently at detecting convergent shifts in evolutionary rates.
Oncolytic HSV therapy increases trametinib access to brain tumors and sensitizes them in vivo
Authors: Yoo Ji Young , Swanner Jessica , Otani Yoshihiro , Nair Mitra , Park Flora , Banasavadi-Siddegowda Yeshavanth , Liu Joseph , Jaime-Ramirez Alena Cristina , Hong Bangxing , Geng Feng , Guo Deliang , Bystry Darlene , Phelphs Mitch , Quadri Haroon , Lee Tae Jin , Kaur Balveen
Published: April 2019

Background

Hyperactivation of the RAS-RAF-MEK-ERK signaling pathway is exploited by glioma cells to promote their growth and evade apoptosis. MEK activation in tumor cells can increase replication of ICP34.5-deleted herpes simplex virus type 1 (HSV-1), but paradoxically its activation in tumor-associated macrophages promotes a pro-inflammatory signaling that can inhibit virus replication and propagation. Here we investigated the effect of blocking MEK signaling in conjunction with oncolytic HSV-1 (oHSV) for brain tumors.

Methods

Infected glioma cells co-cultured with microglia or macrophages treated with or without trametinib were used to test trametinib effect on macrophages/microglia. Enzyme-linked immunosorbent assay, western blotting, and flow cytometry were utilized to evaluate the effect of the combination therapy. Pharmacokinetic (PK) analysis of mouse plasma and brain tissue was used to evaluate trametinib delivery to the CNS. Intracranial human and mouse glioma-bearing immune deficient and immune competent mice were used to evaluate the antitumor efficacy.

Result

Oncolytic HSV treatment rescued trametinib-mediated feedback reactivation of the mitogen-activated protein kinase signaling pathway in glioma. In vivo, PK analysis revealed enhanced blood–brain barrier penetration of trametinib after oHSV treatment. Treatment by trametinib, a MEK kinase inhibitor, led to a significant reduction in microglia- and macrophage-derived tumor necrosis factor alpha (TNFα) secretion in response to oHSV treatment and increased survival of glioma-bearing mice. Despite the reduced TNFα production observed in vivo, the combination treatment activated CD8+ T-cell mediated immunity and increased survival in a glioma-bearing immune-competent mouse model.

Conclusion

This study provides a rationale for combining oHSV with trametinib for the treatment of brain tumors.
Model Choice, Missing Data, and Taxon Sampling Impact Phylogenomic Inference of Deep Basidiomycota Relationships
Authors: Prasanna Arun N , Gerber Daniel , Kijpornyongpan Teeratas , Aime M Catherine , Doyle Vinson P , Nagy Laszlo G
Published: April 2019

Resolving deep divergences in the tree of life is challenging even for analyses of genome-scale phylogenetic data sets. Relationships between Basidiomycota subphyla, the rusts and allies (Pucciniomycotina), smuts and allies (Ustilaginomycotina), and mushroom-forming fungi and allies (Agaricomycotina) were found particularly recalcitrant both to traditional multigene and genome-scale phylogenetics. Here, we address basal Basidiomycota relationships using concatenated and gene tree-based analyses of various phylogenomic data sets to examine the contribution of several potential sources of bias. We evaluate the contribution of biological causes (hard polytomy, incomplete lineage sorting) versus unmodeled evolutionary processes and factors that exacerbate their effects (e.g., fast-evolving sites and long-branch taxa) to inferences of basal Basidiomycota relationships. Bayesian Markov Chain Monte Carlo and likelihood mapping analyses reject the hard polytomy with confidence. In concatenated analyses, fast-evolving sites and oversimplified models of amino acid substitution favored the grouping of smuts with mushroom-forming fungi, often leading to maximal bootstrap support in both concatenation and coalescent analyses. On the contrary, the most conserved data subsets grouped rusts and allies with mushroom-forming fungi, although this relationship proved labile, sensitive to model choice, to different data subsets and to missing data. Excluding putative long-branch taxa, genes with high proportions of missing data and/or with strong signal failed to reveal a consistent trend toward one or the other topology, suggesting that additional sources of conflict are at play. While concatenated analyses yielded strong but conflicting support, individual gene trees mostly provided poor support for any resolution of rusts, smuts, and mushroom-forming fungi, suggesting that the true Basidiomycota tree might be in a part of tree space that is difficult to access using both concatenation and gene tree-based approaches. Inference-based assessments of absolute model fit strongly reject best-fit models for the vast majority of genes, indicating a poor fit of even the most commonly used models. While this is consistent with previous assessments of site-homogenous models of amino acid evolution, this does not appear to be the sole source of confounding signal. Our analyses suggest that topologies uniting smuts with mushroom-forming fungi can arise as a result of inappropriate modeling of amino acid sites that might be prone to systematic bias. We speculate that improved models of sequence evolution could shed more light on basal splits in the Basidiomycota, which, for now, remain unresolved despite the use of whole genome data.
I English Language
Authors: Kostadinova Viktorija , Yáñez-Bouza Nuria , Dreschler Gea , Gregersen Sune , Gyuris Beáta , Allan Kathryn , Scott Maggie , Anderwald Lieselotte , Leuckert Sven , Kraš Tihana , Cogo Alessia , Gan Tian , Parise Ida , Ting Shawnea Sum Pok , Souza Da Silva Juliana , Hansen Beke , Norledge Jessica
Published: April 2019

This chapter has fourteen sections: 1. General; 2. History of English Linguistics; 3. Phonetics and Phonology (not covered this year); 4. Morphology; 5. Syntax; 6. Semantics; 7. Lexicography, Lexicology, and Lexical Semantics; 8. Onomastics; 9. Dialectology and Sociolinguistics; 10. New Englishes and Creolistics; 11. Second Language Acquisition. 12. English as a Lingua Franca; 13. Pragmatics and Discourse. 14. Stylistics. Section 1 is by Viktorija Kostadinova; section 2 is by Nuria Yáñez-Bouza; sections 4 and 5 are by Gea Dreschler and Sune Gregersen; section 6 is by Beáta Gyuris; section 7 is by Kathryn Allan; section 8 is by Maggie Scott; section 9 is by Lieselotte Anderwald; section 10 is by Sven Leuckert; section 11 is by Tihana Kraš; section 12 is by Tian Gan, Ida Parise, Sum Pok Ting, Juliana Souza da Silva and Alessia Cogo; section 13 is by Beke Hansen; section 14 is by Jessica Norledge.
Exploring Validity Evidence Associated With Questionnaire-Based Tools for Assessing the Professional Performance of Physicians: A Systematic Review
Authors: van der Meulen Mirja W. , Smirnova Alina , Heeneman Sylvia , oude Egbrink Mirjam G.A. , van der Vleuten Cees P.M. , Lombarts Kiki M.J.M.H.
Published: April 2019

Purpose

To collect and examine—using an argument-based validity approach—validity evidence of questionnaire-based tools used to assess physicians’ clinical, teaching, and research performance.

Method

In October 2016, the authors conducted a systematic search of the literature seeking articles about questionnaire-based tools for assessing physicians’ professional performance published from inception to October 2016. They included studies reporting on the validity evidence of tools used to assess physicians’ clinical, teaching, and research performance. Using Kane’s validity framework, they conducted data extraction based on four inferences in the validity argument: scoring, generalization, extrapolation, and implications.

Results

They included 46 articles on 15 tools assessing clinical performance and 72 articles on 38 tools assessing teaching performance. They found no studies on research performance tools. Only 12 of the tools (23%) gathered evidence on all four components of Kane’s validity argument. Validity evidence focused mostly on generalization and extrapolation inferences. Scoring evidence showed mixed results. Evidence on implications was generally missing.

Conclusions

Based on the argument-based approach to validity, not all questionnaire-based tools seem to support their intended use. Evidence concerning implications of questionnaire-based tools is mostly lacking, thus weakening the argument to use these tools for formative and, especially, for summative assessments of physicians’ clinical and teaching performance. More research on implications is needed to strengthen the argument and to provide support for decisions based on these tools, particularly for high-stakes, summative decisions. To meaningfully assess academic physicians in their tripartite role as doctor, teacher, and researcher, additional assessment tools are needed.