bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Clinical and Demographic Factors on Quality of Life in End-Stage Renal Disease. A Multicenter Cross-Sectional Study
Authors: Fradelos Evangelos C.
Published: May 2020

The aim of this study was to assess the quality of life (QoL) in end-stage renal disease (ESRD) patients undergoing hemodialysis and to examine the clinical and demographic attributes associated with it.This is a multicenter, cross-sectional study, conducted in 2018, in which 367 patients with ESRD undergoing hemodialysis were recruited. Data were collected through a two-part anon-ymous, self-completed questionnaire. The first part contained questions regarding demographic, social, and clinical information, and the Greek version of Missoula–Vitas Quality of Life Index-15 (MVQoL-15) scale was used to assess QoL. Descriptive and inferential statistical methods were applied. All reported p-values were two-tailed, and the statistical significance level was set at 0.05. Of the study participants, 62.1% were male, with a mean age of 61.80 ±15.11. Of the participants, 67.3% were living in urban areas and 59.1% were married. The majority of the Hemodialysis (HD) patients evaluated possessively all the domains of MVQoL except the wellbeing Domain. QoL was found to be influenced, among others, by age (0.001), occupation (0.002), education (0.003), and additional health problems (<0.001). The role of patient characteristics in QoL is an area of interest, and early and proper intervention is important to enhance QoL.
Victor Nunes Leal, a ciência política e as linhagens do pensamento político brasileiro
Authors: Marino Rafael , Pereira Daniela Costanzo de Assis
Published: May 2020

Resumo: Este trabalho pretende dar continuidade a uma interpretação da obra de Victor Nunes Leal sugerida por Gildo Marçal Brandão em meio ao projeto das linhagens do pensamento político brasileiro, no qual o cientista político uspiano aproxima-o do assim chamado radicalismo de classe média - baseado numa visão democratizante sobre o Brasil e assentado na totalidade social. Para atingir este objetivo, lançaremos mão de algumas obras do autor e fortuna crítica, com o fito de distanciar o pensamento do jurista de interpretações que: a) vinculam-no a certa tradição de ciência política, a qual se estabeleceu no Brasil principalmente sob o paradigma da autonomia da esfera política em relação às demais esferas da vida social; b) ou ao pensamento conservador de Oliveira Viana.
A participação institucional em São Paulo: Trajetória e a experiência no governo Haddad (PT, 2013-16)
Authors: Coelho Rony
Published: May 2020

Resumo O artigo aborda o percurso da participação institucionalizada em São Paulo. A bibliografia identificou momentos em que a participação se expande e se contrai na capital paulista, em um movimento caracterizado como uma “sanfona”. Verificar se essa dinâmica se estendeu à gestão Haddad (PT, 2013-16), é um dos seus objetivos. Recorrendo à análise descritiva, com dados inéditos para o último período, e ao conceito de instituições participativas, pretende-se também traçar um panorama da configuração desses mecanismos e avaliar os dados empíricos analisados à luz dos balanços mais recentes da literatura. Dentre os resultados encontrados, aponta-se que houve não apenas uma ampliação na quantidade de canais de participação em relação às gestões anteriores, mas que a experiência recente foi marcada por diversas inovações, embora tenha sido ofuscada pelo contexto em que se deu.
Influência do Aporte Térmico sobre as Características e Propriedades de Cordões de Solda dos Aços AISI 316 e AISI 316L
Authors: Silva Rafaela dos Santos , Demarque Rudineli , Santos Ellem Patrícia dos , Castro José Adilson de
Published: May 2020

Resumo: Aços AISI 316 e AISI 316L possuem ampla aplicação industrial, por isso a importância de avaliar a soldabilidade dessas ligas. Neste estudo, foi feita análise comparativa entre as amostras de ambos os aços soldados com aportes de 0,5, 1,5 e 2,5 kJ/mm utilizando processo TIG autógeno. Foi analisada a variação do aporte térmico sobre a morfologia do cordão de solda, o espaçamento entre ferritas δ, a fração volumétrica de ferrita δ e a microdureza na zona fundida. Os resultados mostraram que as dimensões do metal de solda, o espaçamento entre as ferritas e a fração volumétrica de ferrita δ tornam-se maiores com o aumento do aporte. As amostras soldadas do aço AISI 316L apresentaram maior espaçamento entre ferritas δ e maiores frações de ferrita δ que o aço AISI 316. Quanto à microdureza, o estudo mostrou que quanto mais próximo do centro da zona fundida, maior é o valor de microdureza, sendo a microdureza do aço AISI 316 maior que a do aço AISI 316L. Através de modelagem computacional foi possível avaliar a distribuição de temperatura ao longo das chapas soldadas e comparar o ciclo térmico obtido por simulação com o ciclo calculado experimentalmente para o aporte de 0,5 kJ/mm.
Elaboração e validação de uma tecnologia educacional acerca da violência contra a mulher
Authors: Sousa Elayne Kelly Sepedro , Morais Erica Jorgiana dos Santos de , Amorim Fernanda Cláudia Miranda , Oliveira Adélia Dalva da Silva , Sousa Kayo Henrique Jardel Feitosa , Almeida Camila Aparecida Pinheiro Landim
Published: May 2020

RESUMO Objetivo elaborar e validar uma tecnologia educacional acerca da violência contra a mulher. Método estudo metodológico de validação de conteúdo e aparência. Para a validação, participaram deste estudo 11 especialistas de conteúdo e técnicos, 7 especialistas de design e 79 mulheres. Foram utilizados três instrumentos para a coleta de dados, um para cada grupo de participantes, e os dados foram analisados quanto ao nível de concordância e Índice de Validade de Conteúdo. Resultados a média de concordância dos especialistas de conteúdo e técnicos foi de 87%, o Índice de Validade de Conteúdo global por parte dos especialistas de design foi de 0,92 e o nível de concordância das respostas positivas pelo público-alvo foi de 96,2%. Conclusão e implicações para a prática o Alertômetro mostrou-se uma tecnologia educacional válida para ser utilizada, pois promove conhecimento acerca das diversas manifestações da violência contra a mulher.
Stream contamination by trace elements: biota incorporation and phytoremediation
Authors: Loureiro Rafael Chaves , Hepp Luiz Ubiratan
Published: May 2020

Abstract: In this review, we present information about the presence of trace elements on streams and the consequences related to the increase of these chemical elements on aquatic systems. Although several studies on trace elements contamination in aquatic environments are conducted on point sources, non-point sources also have a high potential to contaminate water bodies. Some trace elements are important for the development of an organism. However, even essential elements, in high concentrations, may be toxic to aquatic organisms. In some cases, trace elements may accumulate and be transferred along food webs, generating changes in the structure and functioning of terrestrial ecosystems. The phytoremediation techniques could be an important tool in reducing the problems generated by trace elements. Thus, understanding the effects generated by the increase of trace elements concentrations on aquatic ecosystems becomes important to help public managers to apply solutions for the mitigation of this chemical pollution on natural resources.
Emerging Therapeutic Implications of STK11 Mutation: Case Series
Authors: Laderian Bahar , Mundi Prabhjot , Fojo Tito , E. Bates Susan
Published: May 2020

STK11 was first recognized as a tumor suppressor gene in the late 1990s based on linkage analysis of patients with Peutz-Jeghers syndrome. STK11 encodes LKB1, an intracellular serine-threonine kinase involved in cellular metabolism, cell polarization, regulation of apoptosis, and DNA damage response. Recurrent somatic loss-of-function mutations occur in multiple cancer types, most notably in 13% of lung adenocarcinomas. Recent reports indicate that KRAS-mutant non-small cell lung cancers harboring co-mutations in STK11 do not respond to PD-1 axis inhibitors. We present three patients with STK11-mutated tumors and discuss the proposed mechanisms by which germline and somatic alterations in STK11 promote carcinogenesis, potential approaches for therapeutic targeting, and the new data on resistance to immune checkpoint inhibitors.

Key Points

STK11 is a tumor suppressor gene, and loss-of-function mutations are oncogenic, due at least in part to loss of AMPK regulation of mTOR and HIF-1-α. Clinical trials are under way, offering hope to patients whose STK11-mutated tumors are refractory and/or have progressed on chemotherapeutic regimens. Whether gastrointestinal cancers with STK11 loss of function will show the same outcome and potential refractoriness to immune therapy that were reported for lung cancer is unknown. However, physicians managing such patients should consider the experience in lung cancer, particularly outside the context of a clinical trial. In the CheckMate-057 trial lung tumors harboring co-mutations in KRAS and STK11 had an inferior response to PD-1 axis inhibitors. Coupled with the observation that STK11-mutated tumors were found to have a cold immune microenvironment regardless of KRAS status, the conclusion could extend to KRAS wild-type tumors with STK11 mutation. Current data suggest that the use of PD-1 axis inhibitors may be ill advised in the presence of STK11 mutation.
Degree Distance of Zero-Divisor Graph Г[Z_n ]
Authors: YALÇIN N.feyza
Published: May 2020

In this article, degree distance of zero-divisor graph Г[Z_n ] is computed for n=p^2,n=pq and n=p^3, where p,q are distinct prime numbers.
Artic Determination of Dynamic Characteristics the Structure with ARX and ARMAX Estimation Methods
Authors: UYAR Hidayet , AĞCAKOCA Elif
Published: May 2020

In this study, the dynamic behavior of a single-span four-storey steel model structure is tried to determine by using 2 different methods. Connections between beams and columns are produced as rigid and the structure is connected to the shake table by a fixed support. In order to measure the forced vibration values applied to the model structure with the help of the shaking table, the smartphone was placed on the shaking table base and the top of the steel model structure and acceleration records were taken. After the records have been processed, structural algorithm is created using MATLAB autoregressive ARX and autoregressive moving average ARMAX models. Smartphone records from the shake table are defined as inputs and smartphone from the top of the structure are defined as outputs in MATLAB autoregressive ARX and autoregressive moving average ARMAX models. By doing this, structure’s dynamic behavior is to be obtained by MATLAB autoregressive ARX and autoregressive moving average ARMAX models when only vibrating table acceleration record is inputted. Dynamic characteristics obtained by ARX and ARMAX were tried to be confirmed by finite element method using Sap2000 software. In order to determine the dynamic characteristics of the building, the earthquake records of Kobe, Sakarya, Loma-Priate and El-Centro were used as forced vibration. At the end of the study, dynamic properties obtained by numeric models (ARX and ARMAX) using input acceleration record are compared to the dynamic properties obtained by Sap2000 analysis. By doing this it was determined whether dynamic properties can be reliably obtained using autoregressive ARX and autoregressive moving average ARMAX models. Advantages and disadvantages of using this method to define structural behavior are discussed.
Effect of Different Heat Treatments on Mechanical Properties of AISI Steels
Authors: EKŞİ Seçil
Published: May 2020

Heat treatment has great importance on the mechanical properties of materials. This paper reports experiments on effects of heat treatment on the mechanical and microstructures behavior of AISI 1040 and AISI 1060 steel. To analyze the effect of different heat treatments, AISI 1040 specimens were prepared through quenching, quenching and tempering, normalizing and spheroidizing. To understand effect of tempering time/temperature and annealing time on AISI 1060 steel specimens were prepared through annealing and tempering. Tensile test and hardness test were performed on steel specimens. The mechanical properties of steel specimens were correlated with the microstructure of steels.
Mechanical and Electrical Response of Structural Capacitor for Various Dielectric Materials
Authors: EĞRİSÖĞÜT TİRYAKİ Aysun , KURUKAYA Oğuzhan Bartuğ
Published: May 2020

Due to the run out of the fossil energy sources and environmental issues, new energy storage systems are developed in conjunction with renewable energy technologies. The machines that supplied energy from the batteries consume extra energy because they carry both the weight of the batteries and the structural weight. Recently, the idea of storing energy in structural elements has been studied. In this study, the multifunctionality of structural capacitors made by placed of varied dielectric layers between the carbon fiber plates has been investigated. The effects on the mechanical and electrical properties of different dielectric material combinations has been investigated by the simulation, experimentally and by the calculations based on Hook's law. Thus, the results of structural dielectric capacitors in these combinations have been compared and discussed.
Modeling Active Learning in a Robot Collective
Authors: ERBAŞ Mehmet Dinçer
Published: May 2020

In this research, we model an active learning method on real robots that can visually learn from each other. For this purpose, we initially design an experiment scenario in which a teacher robot presents a simple classification task to a learner robot through which the learner robot can discriminate different colors based on a predefined lexicon. It is shown that, with passive learning, the learner robot is able to partially achieve the given task. Afterwards, we design an active learning procedure in which the learner robot can manifest what it understand from the presented information. Based on this manifestation, the teacher robot determines which parts of the classification system are misunderstood and it rephrases those parts. It is shown that, with the help of active learning procedure, the robots achieve a higher success rate in learning the simple classification task. In this way, we qualitatively analyze how active learning works and why it enhances learning.
Alloying Effect on the Local Atomic Pressures of Nanoclusters
Authors: TARAN Songül
Published: May 2020

In this study, simulations were performed to investigate local atomic pressures of icosahedral nanoclusters with 55 atoms. Before analyzing the local atomic pressures, the best chemical ordering structures were obtained using Monte Carlo Basin-Hopping algorithm within Gupta potential. Binary and ternary alloying effect on the local atomic pressures of mono, binary and ternary nanoclusters formed by Cu, Ag and Pt atoms was investigated in detail. It was obtained that adding one atom of second alloying metal in pure nanoclusters and also third alloying metal in binary nanoalloys can change the local atomic pressure due to locating tendency in the icosahedral structure. Also, it was observed that adding a smaller atom at the central site of the icosahedral structure exhibits decreasing of core stress.
Современное состояние горно-лесных почв в бассейне реки Зеямчай и горно-черноземных почв около села Дюзюрт
Authors: Эюбова Зулейха Ифтихар
Published: May 2020

Цель – разработка научной основы предотвращения деградации горно-лесных и горно-черноземных почв и пути их восстановления на исследуемых территориях. В статье рассматриваются естественные и антропогенные деградации горно-бурых лесных почв под буковым лесом, горно-коричневых лесных почв под грабовым и дубовым лесами в бассейне Зеямчай и карбонатных черноземных почв около села Дюзюрт. Рельеф исследуемых территорий сильно эрозионно-опасный, представлен расчлененными низкогорьями, среднегорьями и горными котловинами, изрезанные горными реками. В этих зонах почвы распространяются на сухих низкогорьях и в верхнюю увлажненную часть среднегорья. Результаты и обсуждение. Выяснено влияние некоторых свойств почвы на рост и развитие древесных пород в лесных ценозах. На исследуемых территориях заложены почвенные разрезы. Изучено влияние высоты, крутизны и экспозиции склонов, состава лесного покрова, литологического состава почвообразующих пород и физико-химического состава почвы на интенсивность процесса деградации. Кроме того, физико-химический состав этих почв по почвенному профилю анализируется в сравнении с анализом предыдущих годов (1966-1990).
Вклад С. В. Чефранова и Г. Г. Швиттау в подготовку географических кадров в Воронеже
Authors: Шмыков Виктор Ильич
Published: May 2020

Цель – дать обзор основных этапов жизни и деятельности профессоров С. В. Чефранова и Г. Г. Швиттау, работавших в вузах города Воронежа в довоенный период и участвовавщих в становлении высшего географического образования. В современной географической среде эти ученые и педагоги мало известны, не осталось материалов о их деятельности в городе Воронеже, во время войны были уничтожены архивы вузов и нет теперь живых носителей памяти о них. Проанализированы их научно-педагогический уровень, вклад в подготовку географов для высшей и средней школы в ВГУ и ВГПИ. Профессор С. В. Чефранов являлся одним из соавторов учебников и хрестоматий по физической географии частей света, России и СССР, читал в ВГУ и ВГПИ курс «Физическая география СССР». Это был уровень географического центра образования СССР – Московского университета. Профессор Г. Г. Швиттау представитель научной экономической школы Санкт-Петербургского университета, внесший лично большой вклад в экономическую статистику, трудовое и социальное право. В Воронежском университете и Воронежском пединституте читал курс «Экономическая география зарубежных стран», работал над учебным пособием по курсу, руководил аспирантами. Пройдя замечательную научную школу, опыт работы по ведению научных исследований в Западной Европе, свободное владение десятком иностранных языков, опыт преподавания в Петербургском университете, он пользовался большим уважением преподавателей и студентов. С Воронежем связана загадочная история его интернирования во время войны в Восточную Европу и возвращение на работу в 1945 году. Идеи Г. Г. Швиттау и в настоящее время не утратили своей актуальности.
Subcellular fractionation of suspension Chinese Hamster Ovary (CHO) cells v1
Authors: Perez Rodriguez Saumel , De Jesús Ramírez-Lira María , Wulff Tune , Gunnar Voldbor Bjørn , T Ramírez Octavio , A Trujillo-Roldán Mauricio , A Valdez-Cruz Norma
Published: May 2020

Subcellular fractionation is a widely adopted technique to study cellular biology, and localization and functions of several proteins , and, more recently, it has been applied previous to proteomics to quantify low concentration proteins, and characterize many subcellular organelles . Since CHO cells play a central role for recombinant protein (RP) production, a deeper study of their cellular biology is mandatory in order to construct new cell sub-lines with a more robust RP expression phenotype. Therefore, the goal of the present protocol is to provide the necessary basis for separation of subcellular organelles from suspension Chinese hamster ovary (CHO) cells for a subsequent proteomic study of isolated fractions. Differential and isopycnic centrifugation based sections are presented for enrichment of different subcellular compartments, together with a precipitation section for recovering of proteins from isolated fractions. Isopycnic centrifugation is based on discontinuos sucrose gradients, of which one is adapted from the literature for the separation of nuclear and mitochondrial precipitates , and the other is designed in our laboratory for the separation of the microsomal precipitate. This protocol provides a novel discontinuous sucrose gradient for the separation of the components of the microsomes, which increases the separation efficiency with respect to previously reported protocols .
Minimal Event Distance Aneuploidy Lineage Tree (MEDALT) inference based on single cell copy number profile v1
Authors: Wang Fang , Wang Qihan , Mohanty Vakul , Liang Shaoheng , Dou Jinzhuang , Han Jincheng , Conterno Minussi Darlan , Gao Ruli , Ding Li , Navin Nicholas , Chen Ken
Published: May 2020

This protocol describes two innovative algorithms: 1) A minimal event distance aneuploidy lineage tree (MEDALT) inference algorithm allows implementing genetically meaningful distances and is scalable to current single-cell datasets containing thousands of cells, and 2) A statistical routine, Lineage Speciation Analysis (LSA), enables prioritization of CNAs and genes that are non-randomly associated with the observed lineage expansion and thereby are potentially functionally important.
Recombinant Protein Expression of MMLV-RT H+ v1
Authors: Brown Alex
Published: May 2020

This protocol has been optimized for recombinant expression of molony virus based reverse transcriptases (RT). The plasmid used contains a reverse transcriptase gene which is derived from Moloney Murine Leukemia Virus. The enzyme when expressed recombinantly can synthesizes a complementary DNA strand from single-stranded RNA, DNA, or an RNA:DNA hybrid. The enzyme contains point mutations to generate a highly processive, thermostable, and improved fidelity mutant reverse transcriptase. Details, incluiding the sequence of this enzyme are published and can be found here PMID: 22691702. The enzyme contains an active RNAse H domain and is highly thermostable. The point muitations utilised here are currently filed under a provisioal patent with Thermo Fisher Scientific. Commcercial use of this enzyme must go though Thermo Fisher Scientific. This expression protocol can also implemented to express other MMLV based reverse transcriptases or diversely related retroviral RTs, provided the genes are in an expresison construct with an N- terminal 6-10 His Tag and are expressed under a T7 promoter. The plasmid used can be found on reclone.org
Analisis Putusan Mahkamah Konstitusi Nomor:137/PUU-XIII/2015 Tentang Pembatalan Kewenangan Gubernur dalam Pembatalan Peraturan Daerah Kabupaten/Kota
Authors: Bonadi Ahmad , Syafa'at Rachmad , Sudarsono Sudarsono
Published: May 2020

This paper aims to analyzes the consideration of Constitutional Court judges in canceling Article 251 paragraph (2), paragraph (3), paragraph (4) and paragraph (8) of the Republic of Indonesia Law No. 23 of 2014 concerning Regional Autonomy and the impact of the Constitutional Court Decision Number: 137 / PUU-XIII / 2015. The study uses normative legal research with a statute approach, conceptual approach, and case approach. The decision of the Constitutional Court judges in deciding their cases is based on the principles of constitutionalism, the principle of the unitary state of the Republic of Indonesia, the principle of regional autonomy and decentralization, and the principle of judicial power and rule of law. The impact of the Constitutional Court Ruling Number: 137/PUU-XIII/2015 is the increased burden of the case of material testing rights in the Supreme Court, the abolition of the governor’s authority to cancel district/city regulations, and hinder the deregulation program to accelerate development.
Implikasi Yuridis Peraturan pemerintah tentang Pungutan Otoritas Jasa Keuangan Terhadap Notaris Pemegang Surat Tanda Terdaftar yang tidak pernah Berkegiatan di Pasar Modal
Authors: Puspitasari Ratna Ayu , Koeswahyono Imam , Soekesi Titik Soeryati
Published: May 2020

This paper aims to describe the authority of the Financial Services Authority (OJK) in conducting supervision and regulation of the financial services sector, and the juridical implications of Government Regulation Number 11 of 2014 concerning OJK Levy for capital market notaries registered with Registered Letters (STTD) who are not active in the capital market. The research method used in this paper is a normative juridical. The results of the study indicate that the OJK has the authority to levy notaries. Legal implications arising from Government Regulation Number 11 of 2014 concerning Financial Services Authority Levies for notaries who have STTD but do not engage in capital market activities becomes the state’s receivables. Payments will be made by the state receivable committee, with a forced letter that has the same legal force as the Grosse deed.
Analisis Putusan Pengadilan Negeri Jombang Nomor:15PDT.G/2014/PN.JMB Tentang Peralihan Hak Atas Tanah Dengan Menggunakan Bilyet Giro
Authors: Hartatik Hartatik , Puspitawati Dhiana
Published: May 2020

This paper aims to review the Court Decision Number: 15 / Pdt.G / 2014 / PN.JMB dated October 14, 2014, relating to the validity of the transfer of land rights by buying and selling through payment using Bilyet Giro, and analyzing the settlement of the transfer of land rights using Bilyet Giro according to customary law. The method used in this paper is normative research to find a solution to the problem of transferring land rights through buying and selling using Bilyet Giro to produce a new opinion, theory or concept as a prescription related to the problem. The results of the analysis in this paper show that the payment in full with the Bilyet Giro against the price agreed in the sale of land rights must be declared valid and valuable, both in terms of the Civil Code and the concept of customary law, and according to the provisions of customary law, cash payment with Bilyet Giro is sufficient for the transfer of land rights due to buying and selling.
Technologies of Spectacle and ‘The Birth of the Modern World’
Authors: Röttger Kati
Published: May 2020

The article unfolds a proposal to approach a history of spectacle. With a specific focus on technologies of spectacle it tends to trace the interconnectedness of technics, art and science events across disciplinary and geographical borders at the cusp of modernity around 1800 in Europe. Technics, arts and science went hand in hand to produce a new spectacular knowledge culture resulting from the relation of both analogy and causality between industrial transformation and the social revolution. It is claimed that on the one hand the arrival of new technologies like the steam machine, electricity, magnetism and so on produced the spectacular; on the other hand, spectacular practices like panorama, diorama, and phantasmagoria right up to the melodrama (all emerging in that time) took intrinsically part in the formation of modern societies.
Tussen wetenschap en spektakel
Authors: Wils Kaat
Published: May 2020

Between Science and Spectacle: Hypnosis on the Belgian Theatre Scene, 1875–1900. This article focuses on the performances of itinerant magnetiser/hypnotist Donato and on the public debate he generated on his travels throughout Europe. Around this time, magnetism was increasingly being presented in a new form – hypnotism – which walked the line between scientific experiment and public spectacle, navigating the realms of alternative medicine and of recognised medical therapies. This article explores Donato’s use of the trappings of science in his shows, his relationships with the medical and scientific communities, and the ban on public demonstrations of hypnotism that was introduced in Belgium in 1892. While the Belgian law revealed just how unequal the battle between magnetisers and physicians really was, it did not result in a decisive victory for the medical community, nor did it spell an end to hypnosis shows. However, it did herald the end of a brief period of intense exchange between magnetisers and academics.
Role of risk factors, clinical features and treatment modality in early detection and management of Buerger’s disease: a study from tertiary care centre Pondicherry
Authors: Kiruba Krithika , Koranga Himadra , Ramaraj Chandrasekaran , Takalkar Anant A.
Published: May 2020

Background: Thromboangiitis obliterans is a disease of unknown aetiology seen under 45 years of age with no form of treatment has been successful in offering the victims of this disease a cure nor even a long-term remission. Objective of the study was to study the role of different risk factors, clinical features and treatment modality in early detection and management of Buerger’s disease.Methods: This is an experimental study carried out in 50 cases of Buerger’s disease after obtaining a well-informed written consent in department of General Surgery in Aarupadai Veedu Medical College and Hospital. Period of study was from October 2015 to October 2017. Data was analysed with SPSS 23.0 version.Results: Majority were from 31-40 years age group i.e. 30 (60%). Left lower limb was involved in 52% subjects. 80% smoked more than 20 cigarettes per day. Signs of ischemia was present in all 50 patients. Gangrene of the limb was seen in 14 patients (28%). Out of 3 patients with recurrent pain, 2 (66.7%) were relieved. Ulcer healing occurred in 5 out of 6 patients i.e. 83.3% and intermittent claudication was relieved in 2 out of 7 patients i.e. 28.6%.Conclusions: Males are commonly involved in our study. Majority of patients were in age group 31-40 years. Smoking is an important and definite risk factor in relation with the development of Buerger’s disease. Lower limb is commonly involved. Majority of patients in our series were treated by conservative management.
Research on Health Effects of Environmental Chemicals Based on Structure and Gene Association Analysis
Authors: Zhang Yinbing
Published: May 2020

China is a major producer and consumer of chemicals. The production and use of chemicals play a role in the development of the entire national economy. Therefore, effective chemical management has a huge impact on the development of the national economy. At present, chemical management guidelines have achieved a lot in chemical operations, but there are still many shortcomings. Relevant institutions should further improve the standard system, strengthen the coordination of subjective institutions, the supervision and management, establish information standards, complete information sharing, build a feedback system, strengthen the transformation of experimental results and trust training.
WHICH IS THE MOST APPROPRIATE LEARNING MODEL TO IMPROVE STUDENTS’ ENTREPRENEURIAL INTEREST? A COMPARISON OF TWO KINDS OF ACTION RESEARCH
Authors: Sari Melati Inaya , Jenudin Ahmad
Published: May 2020

Purpose of the study: This study introduced a new learning model called GEPPRAK (Grup: Group, Eksplorasi: Exploration, Pengembangan Ide: Idea Development, Penyusunan dan PresentasiRencana Usaha: Preparation and Presentation of the Business Plan, Aksi dan Kompetisi: Action and Competition)and compared higher education students' interest change in entrepreneurship through the application of the GEPPRAK learning model and the Problem Based Learning (PBL) learning model.

Methodology: This research was quantitative research with an experimental research design. The design in this study was the true experimental design using pre-test and post-test control group design. Data collection used documentation, observation, and questionnaire. Data analysis techniques in this study used an independent sample t-test using IBM SPSS 22.

Main Findings: The results showed that entrepreneurship learning using the GEPPRAK learning model proved to be able to improve entrepreneurial interest better than the Problem Based Learning (PBL) model in the experimental class in this study.

Applications of this study: The results of this study can be used by teachers and lecturers as a reference for the selection of entrepreneurship learning models in schools and universities.

Novelty/Originality of this study: The GEPPRAK learning model is a new learning model developed in Indonesia so that it still needs to be tested for its effectiveness in improving students’ entrepreneurial interest.
Generalization Driven Fuzzy Classification Rules Extraction using OLAM Data Cubes
Authors: Bhukya Raghuram
Published: May 2020

An fuzzy classification rules extraction model for online analytical mining (OLAM) was explained in this article. The efficient integration of the concept of data warehousing, online analytical processing (OLAP) and data mining systems converges to OLAM results in an efficient decision support system. Even after associative classification proved as most efficient classification technique there is a lack of associative classification proposals in field of OLAM. While most of existing data cube models claims their superiority over other the fuzzy multidimensional data cubes proved to be more intuitive in user perspective and effectively manage data imprecision. Considering these factors, in this paper we propose an associative classification model which can perform classification over fuzzy data cubes. Our method aimed to improve accuracy and intuitive ness of classification model using fuzzy concepts and hierarchical relations. We also proposed a generalization-based criterion for ranking associative classification rules to improve classifier accuracy. The model accuracy tested on UCI standard  database.
An Empirical Analysis of Overtime Greek Regional Development Strategies/Policies the Period 1976-2015: The Case of the Region of Thrace
Authors: Stathakis Dr. E. , Stambologlou E.
Published: May 2020

Thrace had and has relatively favor conditions for substantial development, that is, good and adequate physical, environmental and cultural resources, but paradoxically remains the poorest Greek region. What missed was the smart, consistent and effective regional development policies, capable of counterbalancing the disadvantages. Some not well-designed policies, based on generous financial incentives after 1976, contributed very little to its growth because they were fragmentary without focus and cohesion. They supported a shallow growth, unable to create a good/stable and sustainable basis for cost, quality and functional competitive advantages. Our empirical research proves well- documented the insufficiency of regional policies followed the last 40 years, 1976-2015. In this context, we suggest some indicative new regional policies that will have to be based on both, in smart incentives, supporting smart/flexible specialization well-branded globally and in intelligent production systems capable of supporting effectively, either outsourcing production via long term cooperation, or domestic production for niche markets.
Teachers’ Strategies for Managing Adolescent Students with Maladaptive Behaviours in Ghana
Authors: Amoah Charles Agyei , Dontoh Samuel , Adjei Augustine , Amanfo Barnabas Addai
Published: May 2020

Maladaptive behavior is arguably the most common disruptive behaviour among adolescents and in order to transform these students into productive members in the society, the need for quality education cannot be overrated. It is in this regard that this study seeks to examine the strategies that teacher use to manage maladaptive behaviours in Offinso Municipality. A quantitative approach and an explanatory research design was adopted to ensure that the right data is collected and the appropriate analytical techniques are used. Further, Krejcie and Morgan (1970) and stratified random sampling was used to select a total of 171 teachers from the three schools with the aid of questionnaire as the research instrument. All ethical issues were strictly adhered to ensure Full Corporation with the study. SPSS version 22 was used to code and capture the data collected. A combination of descriptive analysis and sequential linear regression was used to analyse the data. The results showed that the students of the three schools in the Offinso Municipality exhibit maladaptive behaviour and the teachers have adapted strategies that significantly manages the maladaptive behaviours. The factors influencing maladaptive behaviour in the adolescents includes parental, environmental and the school. For resource allocation and policy implications, management should first consider committing resources to enhancing the teacher’s strategy before considering the three category of factors influencing the maladaptive behaviour in the adolescent students. Further, management should engage the parents, the community leaders and government to develop strategies in mitigating maladaptive behaviour in adolescent students. The need for counselling service centres cannot be overrated besides orientation practices.
The Role of Organizational Citizenship Behavior as a Mediator on The Effect of Employee Engagement and Organizational Culture on Employee Perfomance in BPJS Ketenagakerjaan
Authors: Nurzam Aghnia Ilmi Sadida
Published: May 2020

The study aims to find out and analyze the relationship between employee engagement, organizational culture, organizational citizenship behavior (OCB), and employee performance. The author administered 224 participants employee engagement scale, organizational culture scale, OCB scale, and employee performance scale in BPJS Ketenagakerjaan East Java area. The data is analyzed by path analysis method in SPSS program. The result indicated that employee engagement and organizational culture affects positive significantly on OCB. Employee engagement, organizational culture and OCB also affects positive significantly on employee performance.
Characteristics of Phosphorus Adsorption and Release in Different Types of Sediments
Authors: Yang Pengqiang , Huanghe  , Gao Rujun
Published: May 2020

Taking different types of sediments as the research object, this research studied the adsorption and release characteristics of phosphorus under different conditions of different temperatures, coexisting heavy metal ion system, organic matter content and sediment particle size. Through used correlation analysis and principal component analysis, it discussed the influence of various factors on the adsorption and release of phosphorus in sediments. The results show that the adsorption of phosphorus by five different types of sediments from different sources reached saturation equilibrium in about 10 hours, and the increasing rates of 0 ℃, 15 ℃ and 30 ℃ are 17.5% ~ 23.7% and 18.2% ~ 38.3%, respectively.  The addition of coexisting heavy metal ion solution accelerated the adsorption of phosphorus in the sediment and reduced the total amount of phosphorus adsorption, that is, heavy metal ions inhibited the adsorption of phosphorus in the sediment; the presence of organic matter in the sediment would reduce its adsorption of phosphorus , Taihu farm and wetland sampling points have the largest sediment organic matter content. Compared with the other three points, the adsorption of phosphorus of these two  points accounted for 20.6% and 22.1%; the adsorption and release of phosphorus by sediment increased with the decrease of particle size. The maximum release rate was 5.216mg/kg-1·h-1. The result of principal component analysis shows that the order of influence on the adsorption and release of phosphorus by sediments is temperature> disturbance> organic matter content> heavy metal ion influence> particle size of sediments.
Morbimortalidad del embarazo gemelar en el Hospital Universitario del Valle
Authors: Cañas Giraldo Camilo Agusto , Cifuentes B. Rodrigo , Montes Héctor Fabio
Published: May 2020

Se presenta la experiencia con relación a morbimortalidad del embarazo gemelar en el Hospital Universitario del Valle-Cali (Colombia), donde se atendieron en un periodo de un año 7890 partos. Hubo 164 casos de embarazo múltiple (1 de cada 48 partos; o sea 2.07%). Hubo 1 mortalidad materna por eclampsia (0.56%) y 39 muertes fetales (11.85% de mortalidad). El 53.8% (21/39) de la mortalidad fetal ocurrió en menores de 750 gramos. Se presentaron trillizos en 1 ocasión (1 en 7890 partos o sea 0.012%) y siameses toracópagos en 1 ocasión. El odds ratio de nacer prematuro por ser gemelar fue de 5.48 (IC 4.9 – 6.1). La mitad de los embarazos gemelares nacieron por cesárea. A diferencia de lo reportado a nivel mundial no se encontraron diferencias en morbilidad o mortalidad en los recién nacidos con relación a su orden de nacimiento.
Prolapso de la cúpula vaginal revisión del manejo médico y quirúrgico
Authors: Sepúlveda Agudelo Janer , Quintero Eliana Maribel , Mejía Martín Bernardo , Oróstegui Correa Simón , Alarcón Nivia Miguel Angel
Published: May 2020

El prolapso de cúpula vaginal no es causa de mortalidad pero si afecta la calidad de vida. Suele estar acompañado de enterocele y en ocasiones de rectocele y/o cistocele con una incidencia entre el 0.5 y el 2%.Siempre que nos enfrentemos a una paciente con prolapso de cúpula vaginal debemos buscar métodos que mejoren la calidad de vida y que preserven en lo posible la función sexual.El tratamiento va desde el uso de pesarios hasta procedimientos quirúrgicos ya sea por vía vaginal o por vía abdominal.Los objetivos del manejo quirúrgico son el alivio de los síntomas, la corrección del defecto del piso pélvico, la restauración del eje normal de la vagina, de la función vesical normal e intestinal y el mantenimiento de un potencial sexual satisfactorio.El abordaje abdominal causa menos dispareunia, menor recurrencia y no afecta el ángulo vaginal; la vía vaginal consume menos tiempo con recuperación postquirúrgica más rápida y menor posibilidad de lesión intestinal.En el presente artículo se hace una revisión del manejo médico y quirúrgico de prolapso de cúpula vaginal.
La ética Vs el abuso de la investigación clínica
Authors: Alarcón Nivia Miguel Angel
Published: May 2020

Se comentan en forma breve las más conocidas e infames investigaciones realizadas en humanos en aras de la ciencia. Se muestra la necesidad de crear y fortalecer los Comités de Ética en instituciones donde se investiga y se exponen las normas vigentes del Ministerio de Salud de Colombia que rigen los estudios con humanos y animales. Este documento está especialmente dirigido a los jóvenes investigadores que dan sus primeros pasos en el campo de la salud humana.
Cultivo y transferencia de blastocistos ¿La respuesta?
Authors: Giraldo Juan Luis , Serafini Paulo , Habana Antonia , Olive Davd
Published: May 2020

En la década de los noventa el desarrollo de la técnica para cultivar y transferir blastocistos luego de una fertilización in vitro ha reportado beneficios en ciertos aspectos cruciales de esta práctica. El mayor control sobre la incidencia de embarazos múltiples es una de sus principales bondades. El proceso de autoselección al que se someten los embriones ha permitido que se transfieran embriones mas viables y con una mayor capacidad de implantarse en el endometrio. También ha contribuido al desarrollo de una nueva ola en la evaluación y el diagnóstico preimplantación del embrión. Detallados análisis de los fenómenos metabólicos cambiantes en el embrión temprano han permitido la aparición de nuevos medios de cultivo que soportan el crecimiento embrionario in vitro hasta su estado de blastocisto. Estos medios están reemplazando al cocultivo como herramienta preferida para cultivar blastocistos. Sin embargo aun existen interrogantes sobre el mecanismo de acción de los cocultivos y sobre la forma en que algunos de sus efectos benéficos como la producción de factores embriotroficos específicos, puedan ser incorporados a los nuevos medios.
Costos comparativos entre laparoscopia ginecológica ambulatoria y Cirugía ginecológica por laparotomía
Authors: Argüello Argüello Ramiro
Published: May 2020

Se comparan costos entre procedimientos ginecológicos que pueden realizarse por laparoscopia operatoria ambulatoria, o por laparotomía. Se utilizaron las tarifas del Instituto de Seguro Social de 1.999, por ser las más utilizadas a nivel nacional. En todos los procedimientos, a excepción de uno, fue mayor el costo (0,7% al 55,7%) al realizarlo por laparotomía. Se analizan las causas de disminución de costos de la laparoscopia en Colombia. Se concluye que en nuestro país la primera opción quirúrgica, para la mayoría de la patología benigna ginecológica intraabdominal, debe ser la laparoscopia ambulatoria, realizada por ginecólogos entrenados y en condiciones adecuadas.
Embarazo y metabolismo de las proteínas
Authors: Osorio O. José Henry
Published: May 2020

El papel de las proteínas como bloques edificadores de nuevos tejidos, es fundamental para el crecimiento y desarrollo fetal. La oxidación proteica (sin tener en cuenta el modelo de la fenilalanina), provee la misma cantidad de energía como combustible en todos los estadíos de la mujer embarazada, así como en la que no lo está. Los demás requerimientos extra de energía en el embarazo avanzado son provistos por un incremento en la utilización de los Iípidos. En la presente revisión podemos recordar los mecanismos básicos y la secuencia de eventos metabólicos relacionados con las proteínas durante la gestación.
Inducción de trabajo de parto con cérvix desfavorable. Experimento clínico aleatorizado doble ciego Oxitocina vs Misoprostol
Authors: Ardila Montealegre Javier , Botero Luis Fernando , Sabogal Germán
Published: May 2020

Se compara la eficacia y seguridad del Misoprostol con la Oxitocina para inducción de pacientes con HIE, RPM y Embarazo Prolongado y cérvix desfavorable (Bishop menor o igual a 6), que tuvieran una edad entre 15 y 45 años; mediante un experimento clínico aleatorizado doble-ciego con doble enmascaramiento. Se reclutan 182 pacientes que se asignan aleatoriamente a los grupos una vez fueran elegibles y de acuerdo a los criterios de inclusión y exclusión ( Antecedente de cesárea y/o cirugía previa en el cuerpo uterino o en el cérvix, sufrimiento fetal agudo o crónico, placenta previa, corioamnionitis, distocias, embarazo múltiple). Se aplicaron en el análisis el T-Test, Pearson Chi2 según el tipo de variable que se analizaba, encontrando que el Misoprostol mostró ser más eficaz para inducir pacientes con cérvix desfavorable, se disminuyó la incidencia de cesáreas por inducción fallida y no se demostró un aumento en la incidencia de SFA en el grupo del misoprostol.
Correlación entre corioamnionitis histológica y clínica en pacientes con ruptura prematura de membranas mayor de 12 horas
Authors: Ortiz Javier U. , Rebolledo Mario A. , Alvarado Ricardo
Published: May 2020

OBJETIVOS: Los objetivos de este estudio fueron: establecer la frecuencia de corioamnionitis histológica en pacientes con ruptura prematura de membranas con y sin evidencia clínica de corioamnionitis, correlacionar los factores de riesgo para desarrollar corioamnionitis y establecer el tipo histológico más frecuente de corioamnionitis en la población estudiadaMATERIALES Y METODOS: Se evaluaron los signos clínicos, histológicos y factores de riesgo para corioamnionitis y las complicaciones maternas y fetales en pacientes con embarazo ;>: 24 semanas, diagnóstico de ruptura prematura de membranas y tiempo ;>: 12 horas entre la ruptura prematura de membranas y el parto.RESULTADOS: De 55 pacientes con ruptura prematura de membranas, 30 (54,5%) no tuvieron corioamnionitis, 18 (32, 7%) tuvieron corioamnionitis histológica únicamente y 7 (12,7%) tuvieron corioamnionitis histológica y clínica. El estadio II (corionitis) fue el más frecuente ( 48% ). La aparición de algún signo clínico favorece el parto por vía vaginal (p = 0,04). Los factores de riesgo no se correlacionan con la aparición de corioamnionitis (p = NS). Se presentó una paciente con endometritis postcesárea y un recién nacido con neumonía in útero.CONCLUSIONES: La corioamnionitis histológica es más frecuente que la corioamnionitis clínica. Los signos clínicos se correlacionan siempre con la corioamnionitis histológica.