bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Nilai-Nilai Kebangsaan Bersumber dari Pancasila dan UUD 1945 dalam Meninjau Strategi Manajemen Sekuriti pada PT. PLN (Persero) Guna Meningkatkan Kepuasan Pemenuhan Kebutuhan Listrik untuk Menyejahterakan Masyarakat Indonesia
Authors: Annisa Karenina Ajie  , Edy Soesanto  , Luthfia Salsabilla
Published: September 2024

PLN is a state-owned company which operates in the fields of electricity generation, electricity supply, telecommunications, finance and maintenance services. In accordance with the existing electricity supply law, the Indonesian state-owned company which is given the authority to manage the electricity industry, starting from the industrial, housing, business, government office and public street lighting sectors is PT. PLN. Apart from that, PT. PLN is also obliged to improve the welfare of the Indonesian people by fulfilling electricity needs in accordance with the 5th principle of Pancasila. The method used in this research is the literature review journal method. This research is to describe the extent to which national values originating from Pancasila and the 1945 Constitution are implemented in PT's security management strategy. PLN to increase satisfaction with meeting the electricity needs of the Indonesian people. The aim of this research is to analyze the implementation of security management strategies at PT. PLN is based on national values, namely the 5th principle of Pancasila and Law Number 30 of 2009 concerning Electricity Articles 28a and 28b. PT. PLN as a state-owned business actor which is fully obliged and responsible for its design in accordance with existing laws, must ensure that the security management system implemented by this company covers security and safety aspects in its operations.
Strategi Brand Image Pada Rumah Makan Ayam Geprek Sai di Kabupaten Lamongan Prespektif Studi Kelayakan Bisnis Islam
Authors: Riris Trimaulida Rahmawati  , Abdurrahman Abdurrahman
Published: September 2024

This study focuses on the strategic brand image of Ayam Geprek Sai Lamongan Branch in the context of Islamic business. This research aims to understand the influence of Islam on consumer perceptions of a company's brand image and its impact on business success, financial performance and reputation. This study uses qualitative and descriptive research methods to analyze the brand image of Ayam Geprek Sai Lamongan Branch. This research focuses on studying the Islamic business environment in Lamongan Regency, especially Rumah Makan Geprek Sai. This research uses descriptive qualitative methods to collect data from restaurants and data sources collected through observations. This study contributes to the understanding of Islamic business feasibility studies and the potential that can contribute to company success.
Pengaruh Brand Ambassador, Brand Image dan Persepsi Harga Terhadap Keputusan Pembelian Produk Kosmetik Emina
Authors: Hana Selfiana  , Retno Susanti
Published: September 2024

The aim of this research is to analyze the significance of the influence of brand ambassadors, brand image and price perceptions on purchasing decisions for Emina cosmetic products in Surakarta. This research is a survey with data types using qualitative and quantitative data. Data sources use primary data and secondary data. The population in this research are all consumers who use Emina products in Surakarta. The total research sample was 100 people with a sampling technique using purposive sampling. Data analysis uses descriptive analysis, multiple linear regression test, t test, F test and coefficient of determination test. The research results show that brand ambassadors have a significant influence on purchasing decisions for Emina cosmetic products in Surakarta, brand image has no significant influence on purchasing decisions for Emina cosmetic products in Surakarta and price perceptions have a significant influence on purchasing decisions for Emina cosmetic products in Surakarta. The F test results show a calculated F value of 38.275 with a significance value (p-value) of 0.000 < 0.05. The coefficient of determination test result (adjusted R2) is 0.530, meaning that the contribution of the independent variables to the dependent variable is 53%.
Dampak Program Bank Sampah Terhadap Tingkat Pendapatan Nasabah Bank Sampah
Authors: Risa Valentine  , Muhammad Yasin
Published: September 2024

One of the major breakthroughs in waste management in Indonesia is the waste bank program. Through this program, it is formed in people's minds that waste is something that is useless and is simply thrown away, converted into something that also has value and price. Through the waste bank, people can save waste, which can then generate money within a certain period of time. Research using descriptive research methods with quantitative analysis. This study aims to find out how the impact of the waste bank program on the socio-economic community in Sememi Village, Benowo District, Surabaya City. Impact is defined as an influence that brings both positive and negative consequences. In this case the impact is aimed at the socio-economic life of the community at the Eka Jaya Garbage Bank, Sememi Village, Benowo District, Surabaya City. Based on the results of data analysis, it was concluded that there was a positive impact on the socio-economic life of the people in Sememi Village, Benowo District after the construction of the Garbage Bank. This is indicated by an increase in people's income, although it is small, it provides significant benefits for the community. Not only income has increased, but health and better social interaction among people, most importantly, a cleaner environment has also increased from time to time.
Pengaruh Good Corporate Governance Dan Firm Size Terhadap Nilai Perusahaan Dengan Profitabilitas Sebagai Variabel Moderasi (Studi Empiris Pada Perusahaan Sektor Pertambangan Yang Terdaftar di Bursa Efek Indonesia Tahun 2019-2022)
Authors: Ratih Kusuma Mawardani  , Imam Baidlowi  , Tatas Ridho Nugroho  , Nur Ainiyah
Published: September 2024

This study aims to examine the effect of independent variables on the dependent variable and examine moderating variables that can support the relationship between the independent variable and the dependent variable. The independent variables used in this study are Good Corporate Governance (GCG) and Firm size, and the dependent variable is firm value and the moderating variable used is profitability. The method used in this research is quantitative method. The population in this study was 59 Go Public companies listed on the Indonesia Stock Exchange in 2019-2022. The sampling technique used in this study was purposive sampling technique and obtained sample results of 13 companies during the 2019-2022 period with a total sample of 52 financial reports. Hypothesis testing in this study used Partial Least Square (PLS) analysis. The results showed that Good Corporate Governance (GCG) and firm size have a significant positive effect on firm value, while profitability has no significant effect in moderating the relationship between Good Corporate Governance (GCG) and firm size on firm value.
Pengaruh Kualitas Pelayanan, Citra Merek dan Persepsi Harga Terhadap Kepuasan Pelanggan Pada Layanan Go-ride
Authors: Sumarah Budi Santoso  , Rayhan Gunaningrat  , Esti Dwi Rahmawati
Published: September 2024

The development of information technology, in terms of the internet is increasing and increasingly making people feel more comfortable to carry out various activities. The transportation business is also not spared from advances in internet technology. Online motorcycle taxis and taxis are a business opportunity that takes advantage of the development of internet technology. Traditional motorcycle taxis and taxis can only be found at the base or contacted by telephone. However, the current access can be accessed using an Android-based application. The emergence of transportation businesses such as Go-jek, Grab, Maxim and Indriver is proof that information technology has also penetrated into public transportation. The type of research used is quantitative research using multiple linear regression analysis techniques. The population in this study were 100 Go-ride service users in Solo Raya. The data collection technique used is questionnaire using the Linkert scale. The conclusions of this study are (1) There is a significant influence between service quality on customer satisfaction, (2) There is no significant influence between brand image on customer satisfaction, (3) There is a significant influence between price perceptions on customer satisfaction, (4) Simultaneously service quality, brand image and price perceptions have an effect on customer satisfaction.
Pengaruh Pelatihan Kerja Dan Disiplin Kerja Terhadap Kinerja Karyawan UPTD Puskesmas Pagu
Authors: Nauvan Dwi Ferdian Penulis  , Iing Sri Hardiningrum  , Anita Sumelvia Dewi
Published: September 2024

The problem in the object of research is the lack of effectiveness of job training in the field of technology, while in work discipline there are still employees who do not carry out discipline on time or are late in working. This thesis aims to prove the hypothesis of the researcher: there is a partial influence of Job Training (X1), Work Discipline (X2), on employee performance (Y). This study used quantitative methods with multiple linear regression analysis techniques. This research data was obtained by interview, observation, literature study, and questionnaire methods. The sample return in this study used a saturated sampling technique, namely all employees of UPTD Company. Puskesmas Pagu as many as 32 people. The results of the study using the help of SPSS program proposal version 25, showed that: (1) job training has a partial but not significant effect on employee performance with a calculated value of -1.381 and a value of Sig. 0.178 > 0.05. (2) and work discipline partially affects employee performance with a calculated value of 3.795 and a value of Sig.0.001 < 0.05 (3) job training, and work discipline simultaneously has a significant effect on employee performance with a value of Fcalculate 13.489 and a value of Sig. 0.003 < 0.05. From the test results of multiple linear regression analysis, it produces the equation formula Y = 13.489 + -1.381 X1 + (3.795X2) + e.
Analisis Break Event Point (BEP) Sebagai Alat Perencanan Laba Jangka Pendek Pada UMKM Cafe Limas Palembang
Authors: Sinta Agustiani Putri  , Eka Jumarni Fithri
Published: September 2024

This final report is made to help performing profit planning with fixed costs and variable costs as a basis in doing profit planning using Break Even Point (BEP). The title of this final report is "Break Even Point Analysis As A Short Term Profit Planning Tool at UMKM Café Limas Palembang". In completing this final report the authors obtained data by conducting field research through interviews and observation, library research. Based on the data that the author obtained, the company has not done separation of fixed costs and variable costs, so the company does not know how much fixed costs and variable costs, calculation of Break Even Point (BEP) and Margin of Safety (MOS) calculation, which are useful as a tool of corporate profit planning. The author suggests that company should classify fixed costs and variable costs in advance in order to perform calculation of Break Even Point (BEP), calculation of Margin of Safety (MOS) and profit planning.
Pengaruh CAR, NPF, FDR Terhadap Profitabilitas Bank Umum Syariah di Indonesia Dengan Pembiayaan Sebagai Variabel Mediasi
Authors: Ulfatul Khasanah
Published: September 2024

The purpose of this study is to determine the financing ability to mediate CAR, NPF and FDR on the Profitability of Sharia Commercial Banks in Indonesia. This study used a quantitative approach with secondary data types. The sample of this study is a sharia commercial bank registered with OJK for the period 2016 to 2020. By using purposive sampling, 9 Islamic banks were obtained. This study used PLS-SEM analysis. The results showed that CAR, NPF and FDR had a positive effect on profitability. While financing has no effect on profitability. This has an impact on the financing ability to mediate CAR, NPF and FDR. These three variables have not been able to be mediated by financing to profitability.
Pengaruh Kesulitan Keuangan, Perjanjian Hutang, dan Harga Transfer terhadap Penghindaran Pajak yang Dimoderasi Kepemilikan Asing
Authors: Salsabila Salsabila  , Nera Marinda Machdar
Published: September 2024

In Indonesia, the effort to maximize tax revenue is not without obstacles. In the process of tax reform carried out by the government, differences in the interests of the government and the business world become apparent. The existence of these differences causes tax avoidance by the taxpayer. Researchers made this scientific article, aiming to examine and examine the effect of financial difficulties, debt agreements and transfer prices on tax avoidance moderated by foreign ownership. This study uses a qualitative descriptive method to examine a phenomenon by describing the data obtained from literature studies. The results of this study indicate that the variables of financial difficulties, debt agreements, and transfer prices affect tax avoidance. As well as financial difficulties, debt agreements, and transfer prices are able to be moderated by foreign ownership on tax avoidance.
Pengaruh Inovasi, Kreativitas Dan Etika Bisnis Terhadap Bisnis Dalam Novel Gadis Kretek Karya Ratih Kumala
Authors: Satria Kamal  , Muhammad Fajar Ramadan  , Eva Dwi Kurniawan
Published: September 2024

This research aims to find out and prove that innovation, creativity and business ethics are needed for business sustainability in the novel Gadis Kretek by Ratih Kumala. The method used is a qualitative method with a descriptive approach based on the novel Gadis Kretek by Ratih Kumala. The results of this research are about the importance of innovation, creativity and business ethics in business sustainability as well as the importance of making business innovations that can keep up with current developments.
Analisis Dinamika Proses Antara Le Minerale Dan Aqua Dalam Industri Air Mineral
Authors: Reditya Putra Octevio Rezky  , Sandi Hardiansya  , Syamsul Hidayat 
Published: September 2024

This research aims to analyze the impact of the high demand for quality water by the community on the popularity of Bottled Drinking Water (BDW). The primary focus involves considerations of product innovation, market expansion, and consumer preferences for naturally sourced products. Additionally, the study will assess the consequences of high BDW consumption, particularly from specific brands, on plastic waste issues. Solutions in the form of green consumer behavior will also be examined as a step to address the negative environmental impact, especially in Indonesia, which faces limitations in plastic waste management. In tackling the complexity of these challenges, this research investigates the consumer purchasing decision process related to BDW, identifies factors influencing the community's need for quality water, and evaluates innovations in BDW products to meet consumer demands for instant and high-quality water. By detailing the research findings, the ultimate goal is to formulate recommendations to enhance the sustainability of BDW, including concrete steps in plastic waste management and increasing awareness of environmental issues.
Analisis Anggaran Biaya Produksi dalam Menunjang Efektivitas Pengendalian Biaya Produksi untuk Meningkatkan Laba
Authors: Tiya Bella Aprillia  , Sri Luayyi  , Fauziyah Fauziyah
Published: September 2024

It is important for companies to calculate production cost budgets in order to increase a company's profits. Researchers conducted research on CV. GTT Kediri by calculating the production cost budget. The researcher aims to find out how production cost budget analysis supports the effectiveness of controlling production costs to increase profits. In this research, researchers used quantitative descriptive research. The data sources used in this research are interviews and documentation as well as the analysis techniques used, namely calculating the production cost budget, calculating the effectiveness of production costs, calculating the cost of production, and comparing profit and loss report data from the company with research results. The result of this research is that by calculating the production cost budget, it proves that production costs can be said to be effective because the results are above 90%. Calculating the production cost budget is able to increase company profits, the company's net profit data for 2022 is IDR 767,264,000. then the net profit results from the research without using the 2023 production cost budget calculation were IDR 892,934,000 and the profit and loss results from research using the 2023 production cost budget calculation were IDR 901,705,000.
Private International Law: Some Development Trends, Traditional and Novelization Institutions
Authors: Sinitsyn Sergey
Published: September 2024

The unprecedented impact of technology on society, the dramatic change in the climate of international relations due to the economic blockade of the Russian economy had a direct and immediate impact on the development of national law and private international law. This is not about slowing down, but about reversing the processes of globalization. The agenda includes the issues of updating the personal statute of a legal entity, the tort statute in the aspect of personal rights protection, the formation of the statute of intellectual property rights and securities in Russian legislation. Relations on the use of artificial intelligence systems, cryptocurrencies and blockchain require special regulation in private international law. The aggressive anti-Russian sanctions policy of the United States and Europe necessitates the modernization of public order regimes and superimperative norms, and the development of regulation of foreign property expropriation in Russian law. This article is devoted to the discussion of these issues, prepared on the basis of the author's report at the plenary session of the XVII Scientific Readings in memory of Professor S. N. Bratus.
Predicting Stock Prices using Data Mining Technique
Authors: Thi Thu Thuy Nguyen , Nghiem Thi-Lich
Published: September 2024

The stock market, for a long time, has been known as a complicated yet captivating system. It is a mainstream investment platform for both beginners and financially savvy people to grow and hold their assets. While it remains a good way to earn profit, the stock market is often considered as one of the risky approaches, mostly due to the nature of the field, and an enormous number of various factors that not often welcome the naïve investors. Therefore, the demand for using a tool that can support us on an overall view of the market trends, facilitating the financial analysis and strategies to identify the optimal time to purchase stocks and the actual stocks to purchase has risen for many years recently. In this study, we focus on using data mining techniques that can support investors in predicting the stock price with existing data from previous phrases. Given data is taken from Yahoo Finance within the 7-year period from 2015-2022. This data will be used to train the algorithms, then we can decide which one is the most suitable for the data mining tools to give the best suggestions for investors.
Correlation of Vitamin D and Core Stabilization Exercise in Low Back Pain: A Narrative Review
Authors: Patel Lilima , Alagesan Jagatheesan
Published: September 2024

Background and Aim: Low back pain is a complex condition that can have various causes and its management involves multiple treatment strategies as per the cause. Use of vitamin D supplementation for LBP has gained attention due to its anti-inflammatory effect and helps to improves bone density whereas core stabilization exercises can help to strengthen core and spinal muscles and stabilize the spine. While there is evidence to suggest that both Vitamin D and core stabilization exercise may have potential benefits for low back pain, the direct correlation between these two factors is not well established. So the aim of this narrative review is to find out the correlation of Vitamin D and Core Stabilization exercise in low back pain. Methods: We searched the articles using PubMed and Google Scholar regarding the correlation of Vitamin D and Core Stabilization exercise in male and female low back pain subjects. Results: Evidence from human studies suggest that Vitamin D and core stabilization exercises both are important for overall functioning of intervertebral disc integrity and its stability. Vitamin D is a vital nutrient that plays a critical role in maintaining bone health, regulating the immune system, and reducing inflammation whereas Core stabilization exercises improves core and spinal muscle strength that stabilizes the spine. Conclusions: Clinicians caring for patients must be aware of this Vitamin D and Core stabilization exercises to find the right treatment course for each patient. In many cases quick Vitamin D supplementation along with Core stabilization exercises may be used to manage LBP. While there is a rightful role for Vitamin D in management of lumbar low back pain, non-pharmacological options like Core stabilization exercises should also be considered as they can play an important role in physiotherapy management of low back pain.
Representasi Nilai-Nilai Karakter di Kampung Naga Sebagai Referensi Pengembangan Bahan Ajar Pendidikan Pancasila dan Kewarganegaraan
Authors: Suherman Ade , Sekti Pipyn Hidroga , Hidayat Rahmat , Akbar Gilang Muhamad , Yusup Dani Mulyadi , Sutisna Muhamad
Published: September 2024

This study examines the representation of character values in Naga Village as a reference for the development of teaching materials for Pancasila and Citizenship Education (PPKn). Naga Village, as a traditional community in West Java, has local wisdom that is rich in cultural and moral values, such as environmental values, maintaining a clean and healthy lifestyle, fostering spirituality, applying discipline, and showing strong social concern. This study uses a qualitative approach with a case study method to explore how these values are integrated in the daily life of the people of Naga Village. Data was obtained through observation, in-depth interviews, and document analysis. The results of the study show that the character values in Naga Village are very relevant to the educational goals of PPKn, especially in the formation of attitudes and behaviors in accordance with Pancasila. Therefore, these values can be used as an important reference in the development of contextual and applicable teaching materials for students, in order to strengthen character and citizenship education in Indonesia.
Travesías y negociaciones en el Altiplano mexicano: Recolectores médicos, aficionados y empresarios de especímenes botánicos
Authors: Cházaro Laura
Published: September 2024

This paper contributes to studies on the practices of collectionism, going beyond the institutional histories of museums and herbariums to examine how specimens were collected and to identify the people who consolidated those practices. Centered on research by Mexico’s Instituto Médico Nacional (IMN, National Institute of Medicine, Mexico City, 1890-1915), I trace the itineraries and explorations of various figures: naturalists, collectors, physicians, and entrepreneurs. The article describes the distinct strategies these figures used to collect medicinal plants, animals, and minerals in rural areas, far from the spaces of scientific institutions. Through the accounts of the naturalist Fernando Altamirano (1848-1908) of the IMN, and the American Cyrus Guernesey Pringle (1838-1911) of the Gray Herbarium and Smithsonian Institution, I visit the places where they collected, focusing as well on the invisible actors who participated in those searches for knowledge, includ- ing indigenous peasants and peons who, from the countryside, contributed significantly to their medical and botanical surveys of “Mexico’s nature.”
Pengaruh Citra Merek dan Kualitas Produk terhadap Keputusan Pembelian Laptop merek Asus di Tenggarong
Authors: Wildan Muhammad Wildan , Wijayanti Silvana Kardinar , Hendra
Published: September 2024

This study entitled The Effect of Brand Image and Product Quality on Purchasing Decisions for Asus brand laptops aims to determine the effect of brand image on purchasing decisions, the effect of product quality on purchasing decisions and the effect of brand image and product quality on purchasing decisions for Asus brand laptops. This study uses two independent variables, namely brand image and product quality and one dependent variable, namely purchasing decisions. The data in this study were collected through distributing questionnaires to 100 Tenggarong people who used Asus brand laptops as research samples. The sampling technique used was purposive sampling. Based on data analysis, the results showed that the indicators in this study were valid and reliable. In the classical assumption test, the data is normally distributed, there is no heteroscedasticity and multicollinearity. In the hypothesis test in the t test it is known that the brand image variable has a significant effect on purchasing decisions, the product quality variable also has a significant effect on purchasing decisions. In the F test it is known that brand image and product quality have a joint effect on purchasing decisions. In the R2 test, it is known that the magnitude of the influence of brand image and product quality on purchasing decisions is 87.8%. While the remaining 12.2% is influenced by other factors outside the brand image and product quality variables.
The Effectiveness of Social-Cognitive Competence Skills Training on Positive Affects and Executive Functions of Adolescents
Authors: Kahaki Fatemeh
Published: September 2024

Background and Objective: Executive functions and positive affect are crucial aspects of adolescents' psychosocial development, significantly impacting their well-being and academic and social success. This study aimed to evaluate the effectiveness of social-cognitive competence skills training on positive affect and executive functions in adolescents. Methods and Materials: This randomized controlled trial included 40 adolescents (22 boys and 18 girls) from district 11 of Tehran. Participants were randomly assigned to experimental (n = 20) and control (n = 20) groups. The experimental group received ten 75-minute sessions of social-cognitive competence skills training. Data were collected at three stages: pre-test, post-test, and three-month follow-up, and analyzed using repeated measures ANOVA and Bonferroni post-hoc test. Findings: The results indicated that social-cognitive competence skills training significantly improved executive functions (F = 46.27, p < .001) and increased positive affect (F = 56.18, p < .001) in the experimental group. The mean scores for executive functions in the experimental group increased from 30.25 in the pre-test to 42.68 in the post-test and 41.87 at follow-up. The mean scores for positive affect increased from 22.45 in the pre-test to 34.89 in the post-test and 33.97 at follow-up. Conclusion: Social-cognitive competence skills training can significantly enhance executive functions and increase positive affect in adolescents. These findings underscore the importance of implementing similar educational programs in schools and counseling centers to improve adolescents' psychosocial well-being.
The Effectiveness of Emotion-Focused Therapy on Resilience and Emotion Regulation in Women Experiencing Domestic Violence
Authors: Vejdani Najmeh , Ahmadian Hamzeh , Yarahamdi Yahya , Karimi Qumarth
Published: September 2024

Background and Objective: The present study aimed to determine the effectiveness of emotion-focused therapy on resilience and emotion regulation in women experiencing domestic violence in Tehran. Methods and Materials: This semi-experimental study employed a pre-test and post-test design with experimental and control groups and follow-up. The statistical population comprised all women victims of domestic violence in Tehran who visited psychological clinics in the first half of 2023. Participants were selected voluntarily through convenience sampling and divided into two groups: an experimental group (15 individuals) and a control group (15 individuals). The experimental group received 12 sessions of 90-minute group emotion-focused psychotherapy, while the control group remained on a waiting list. The measurement tools used in the study were the Connor-Davidson Resilience Scale (2003) and the Emotion Regulation Questionnaire (Garnefski & Kraaij, 2006). Data analysis was conducted using SPSS version 23 in both descriptive and inferential sections (mixed ANOVA). Findings: The results indicated that emotion-focused therapy increased resilience in women experiencing domestic violence. Additionally, the findings showed that emotion-focused therapy enhanced emotion regulation in these women. Conclusion: Therefore, it can be concluded that group emotion-focused psychotherapy is an effective method for improving resilience and emotion regulation in women experiencing domestic violence.
Vital A Fish: A Critical Review of Zebrafish Models in Disease Scenario and Case Reports Screens
Authors: Filik Nurdan
Published: September 2024

ABSTRACT
Virtually every major medical advance of the last century and at still has depended upon research with animals. Zebrafish's journey from the ocean to the laboratory leads to major scientific breakthroughs. Transparency structure of zebrafish helps in monitoring their internal structures and are permitting scientist to see effectes of nano particles in fish. Their organs share the same main features as humans and so can be used to study human developmental processes. Zebrafish congruence 70% of their genes with humans, and 84% of ailment-depended genes have zebrafish congruence. The zebrafish embryos can also genetically modified. Certain fishes like zebrafish are able to regenerate damaged retinal nerve cells. Müller galia cells in retina of zebrafish can transform in response to injury and act like stem cells to regrow the retina and replace all damaged neurons. Though humans have the same exact Müller galia cell, they don’t respond to damaged in the same way. Zebrafish are also very responsive to having their genomes edited. Zebrafish regenerate some tissue such as heart in during larval stage. In additionaly zebrafish are used as an animal model to study pharmocology – how drugs work and what they do to an organism’s body. Aim of this review, here, we review current knowledge of how these specialized structures and model organism by focusing on cellular behaviors and molecular mechanisms, highlighting findings from in vivo models and briefly discussing the recent advances in tissue cell culture and organoids. Review discusses the applications of human organoids models of disease on model organism and outlines the ailment treatments.
Respiratory mechanics characteristics at the time of barotrauma presentation in patients with critical COVID-19 infection
Authors: Steckert Gabriela Vieira , Borba Sophia Andreola , Marchese Gabriela Meirelles , Medeiros Fabrício Schultz , Garcia Tiago Severo , Boniatti Marcio Manozzo , Wawrzeniak Iuri Christmann
Published: September 2024

ABSTRACT Objective: To evaluate how ventilatory support, the duration of invasive ventilatory support use and lung mechanics are related to barotrauma development in patients who are severely infected with COVID-19 and who are admitted to the intensive care unit and develop pulmonary barotrauma. Methods: Retrospective cohort study of patients who were severely infected with COVID-19 and who developed pulmonary barotrauma secondary to mechanical ventilation. Results: This study included 60 patients with lung barotrauma who were divided into two groups: 37 with early barotrauma and 23 with late barotrauma. The early barotrauma group included more individuals who needed noninvasive ventilation (62.2% versus 26.1%, p = 0.01). The tidal volume/kg of predicted body weight on the day of barotrauma was measured, and 24 hours later, it was significantly greater in the late barotrauma group than in the early barotrauma group. During the day, barotrauma was accompanied by plateau pressure and driving pressure accompanied by tidal volume, which significantly increased in the late barotrauma group. According to the SAPS 3, patients in the early barotrauma group had more pulmonary thromboembolism and more severe illness. However, the intensive care unit mortality rates did not significantly differ between the two groups (66.7% for early barotrauma versus 76.9% for late barotrauma). Conclusion: We investigated the effect of respiratory mechanics on barotrauma in patients with severe COVID-19 and found that 25% of patients were on nonprotective ventilation parameters when they developed barotrauma. However, 50% of patients were on protective ventilation parameters, suggesting that other nonventilatory factors may contribute to barotrauma.
EVALUATION OF THE GLYCOREGULATION EFFICACY BEFORE AND AFTER TREATMENT WITH INSULIN DEGLUDEC IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN THE REPUBLIC OF NORTH MACEDONIA
Authors: VELKOSKA NAKOVA Valentina , NAKOV Zoran , JANEVA Ruzica , VOLKANOVSKA ILIJEVSKA Cvetanka
Published: September 2024

Patients with type 2 diabetes mellitus (T2DM) who have unsatisfactory glycoregulation with concurrent use of basal insulin and oral hypoglycemics, should be switched to a more intensive therapy regime. To evaluate the efficacy of newly available insulin degludec 70/insulin aspart 30 (IDegAsp), we retrospectively analyzed glycoregulation in 131 patients with T2DM treated with this insulin. All 131 patients were with unsatisfactory glycoregulations, and were switched to IDegAsp from other insulins (except basal-bolus insulin regimen). After a mean period of 11.75±5 months of the treatment with IDegAsp, we found statistically significant improvement in fasting and postprandial glucose levels, and HbA1c (12.5±4.4 vs. 8.8±3.9mmol/l, 13.2±4.6 vs. 9.6±4.1mmol/l, 9.7±1.8 vs. 8.1±1.6%, p<0.01, respectively). The total average daily dose of insulin units (IU) was the same, and there weren’t statistically significant differences in the frequency of hypoglycaemia (p<0.05). From the results, we can conclude that patients with T2DM, who switched to IDegAsp from previous antidiabetic insulin treatment (except basal-bolus insulin regimen) had improved glycaemic control without increased insulin units, and without higher risk for hypoglycemia.
Industrial Online Gambling as Dangerous Cyber Crime in Indonesia
Authors: Susanto Budi , Suhana  , Husain Azis
Published: September 2024

Currently, the reality of a lifestyle that tends to be consumptive, especially combined with the increase in daily necessities due to the speedy rate of economic inflation, makes everyone want to achieve everything practically and instantly, or they think it is easy. One of the things done is gambling. Gambling is a criminal act, i.e., risking a certain amount of money where the winning party will get the entire bet. Gambling can also be referred to as a matter of luck, as it can harm society and the nation's moral values. This crime also disturbs public order, peace, and security. In addition, the influence of gambling does not only affect adults but the impact of gambling also affects children. The Online Gambling Task Force (Satgas), formed by President Joko Widodo and the Financial Transaction Reporting and Analysis Center (PPATK), found several findings related to online gambling in Indonesia. Among them, the turnover of online gambling money reached Rp 600 trillion, and the flow of funds flowed to several countries abroad, including several ASEAN countries such as Cambodia, Vietnam, Thailand, and the Philippines. Online gambling turnover will reach 600 T, and the January-March 2024 period will reach 100 T. A total of 2,370,000 residents are addicted to online gambling, 2% (800,000) of children under the age of 10 years.
The Development and Application of Biosensors in Medical Diagnostics in Indonesia
Authors: Sabrina Hayati  , Abdul Karim
Published: September 2024

Biosensors are analytical devices that combine biological sensing elements with physicochemical detectors to provide rapid, accurate, and cost-effective solutions for medical diagnostics. Globally, these devices have revolutionized the detection and monitoring of diseases, significantly impacting patient outcomes. In Indonesia, the adoption and development of biosensor technology have accelerated over the past decade, particularly in response to the growing healthcare needs and the government's push for technological innovation. This study aims to review and analyze the development and application of biosensors in Indonesia medical diagnostics sector between 2014 and 2024. The research focuses on identifying key technological advancements, the integration of biosensors into healthcare, the challenges faced in their development and deployment, and the prospects for future growth. The study employs a comprehensive literature review and analysis of scientific publications, industry reports, and government documents related to biosensor technology in Indonesia. The review covers the evolution of biosensing materials, point-of-care testing applications, integration with digital health technologies, and regulatory frameworks. Data were synthesized to provide a detailed overview of the current state of biosensor technology and its impact on medical diagnostics in Indonesia. The findings indicate significant advancements in biosensor technology, particularly in the development of novel nanomaterials, the integration of biosensors with mobile health (mHealth) platforms, and the expansion of point-of-care testing (POCT) for infectious diseases. However, the sector faces challenges, including technological limitations, regulatory hurdles, and economic constraints, which have slowed the widespread adoption of biosensors in clinical settings. Despite these challenges, the future of biosensors in Indonesia appears promising, with continued investment and innovation expected to drive further advancements in this field.
The Impact Of Clients' Knowledge On Compliance With Anti-Tuberculosis Medication At Home
Authors: Jelita Siburian  , Rotua Elvina Pakpahan  , Vina Ys Sigalingging
Published: September 2024

Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, namely acid-fast bacteria. Successful treatment of patients with tuberculosis (TB) is a problem in today's society. One of the reasons for the increase in pulmonary TB cases is the low level of education of sufferers. One of the causes of failure of tuberculosis treatment therapy is the side effects of anti-tuberculosis drugs (OAT) which can affect the adherence to medication in tuberculosis patients. The success of TB treatment is compliance in taking anti-tuberculosis medication at the prescribed dose. The aim of this research was to determine the relationship between clients' knowledge of pulmonary tuberculosis and compliance with taking anti-pulmonary tuberculosis medication at Harapan Pematang Siantar Hospital. This research was conducted at Harapan Pematangsiantar Hospital in May 2023. This type of research is descriptive quantitative correlational with a cross-sectional approach. Data collection was carried out using a questionnaire with the Gutman scale. The population of this study was all outpatient clinic patients at Harapan Pematang Siantar Hospital in October-December 2022. The sampling technique was accidental sampling, namely 58 respondents who came in May 2023. Statistical test results used the chi square test with a confidence level of 95% (α = 0.05) shows the p value = 0.001, meaning that there is a relationship between the level of knowledge of tuberculosis clients and compliance with taking anti-tuberculosis medication at Harapan Pematang Siantar Hospital in 2023
School Heads’ Decision – Making Styles And Educational Leadership: Their Influence On School Culture
Authors: Guillergan Yves
Published: September 2024

This study investigated the influence of school heads' decision-making styles and educational leadership on school culture, as perceived by teachers in the Schools Division of Iloilo City, Philippines. Utilizing a descriptive-correlational design and stratified random sampling, 350 teachers assessed their school heads' decision-making styles, educational leadership levels, and the prevailing school culture. Findings revealed a predominance of the Planner decision-making style among school heads, with no significant variations observed across teacher demographics. The level of educational leadership was generally perceived as very satisfactory, although differences emerged based on school level and teacher experience. While the dominant school culture wasn't explicitly identified, significant variations were found based on school level and length of service. Importantly, both decision-making styles and educational leadership were found to significantly influence school culture, highlighting the crucial role of school heads in shaping a positive and effective learning environment. The study underscores the importance of context-specific leadership approaches and collaborative decision-making in fostering a conducive school culture.
MADE IN DIGITAL SPACES: CONNECTING, (RE)DEFINING AND (RE)ACTIVATING CRAFTS
Authors:   Institute of Art History Faculty of Philosophy University of Belgrade Belgrade, Serbia, Đorđević Marija
Published: September 2024

Contemporary approaches to cultural heritage insist on procuring new ways of understanding and utilizing of objects and knowledge that is important for local communities, societies, and humanity. Following the demand within the humanities to establish applied research practices, heritage studies are defining new methods that understand cultural heritage as living practices of communities, that should foster development, diversity, and emancipation. The development of cultural/creative industries brings together the holistic approach to heritage, characterized by mindful application of objects and practices in contemporary cultural production; and with the fast development of digital domain and its functions in heritage field, the demand for connecting, (re)defining and (re)activating “traditional” crafts is becoming even more vocal. This paper will provide an insight in the emancipatory potential cultural/creative industries, the digital domain and traditional heritage intuitions can have when intangible cultural heritage is in question, through an example of the project MADE IN Platform for contemporary crafts and design.
REPORT | Media and Politics: An Arab Media & Society Symposium
Authors: Aly Basem
Published: September 2024

The Kamal Adham Center for Television and Digital Journalism in the School of Global Affairs and Public Policy at the American University in Cairo (AUC) hosted a symposium on “Media and Politics” on Wednesday, May 24, 2017. The symposium, which brought together professors specialized in multiple scholarly disciplines, senior journalists, diplomats, and legal experts was organized by the Research and Publications Division of the center. International students from several countries, including Indonesia, South Africa, Malaysia, India, Chad, and Thailand, attended the event, which was extensively covered by Egyptian private and state-owned media outlets.
Preliminary Assessment of the In Vitro Immunological Activity of Native Lactobacillus Strains from
the Ecuadorian Amazon
Authors: Scalvenzi Laura , Torres Gutiérrez Roldán , Cerda Mejía Liliana , Riofrio Carrión Andrea , Pérez Quintana Manuel
Published: September 2024

The isolation and characterization of new Lactobacillus strains from fermented traditional foods is a global
trend as it enhances the potential for discovering novel probiotic foods. The fermented cocoa (Theobroma
cacao) mucilage is an intriguing substrate for isolating lactic acid bacteria involved in fermentation. This study
represents a preliminary investigation into the isolation, quantification, characterization, and immunological
activity of Lactobacillus strains derived from cocoa beans sampled from two farmer associations (Kallari and
Wiñak) in the Ecuadorian Amazon region. A mother culture was prepared using fermented cocoa pulp, cultivated on selective MRS media. After growth, the isolates were morphologically characterized. A significantly
higher bacterial concentration was recorded in Kallari Association samples if compared with Wiñac. A total
of 25 strains were isolated, eight of which were rod-shaped and positive to catalase tests and were characterized as Lactobacillus. In vitro, immunological activity was performed on differentiated THP-1 cell lines. Cells
were treated with bacterial concentrates, and immunological activity was determined through interleukin-10
expression. Results indicated that W6 strain showed the highest immunological activity. These results indicated that Lactobacillus strains isolated from fermented cocoa pulp in the Ecuadorian Amazon show promise
as a new source of probiotics.
Keywords: cocoa; lactic acid bacteria; biological activity; isolation; cocoa fermentation; probiotics; cocoa
pulp
Stimulus representation in human frontal cortex supports flexible control in working memory
Authors: Shao Zhujun , Zhang Mengya , Yu Qing
Published: September 2024

When holding visual information temporarily in working memory (WM), the neural representation of the memorandum is distributed across various cortical regions, including visual and frontal cortices. However, the role of stimulus representation in visual and frontal cortices during WM has been controversial. Here we tested the hypothesis that stimulus representation persists in the frontal cortex to facilitate flexible control demands in WM. During functional MRI, participants flexibly switched between simple WM maintenance of visual stimulus or more complex rule-based categorization of maintained stimulus on a trial-by-trial basis. Our results demonstrated enhanced stimulus representation in the frontal cortex that tracked demands for active WM control and enhanced stimulus representation in the visual cortex that tracked demands for precise WM maintenance. This differential frontal stimulus representation traded off with the newly-generated category representation with varying control demands. Simulation using multi-module recurrent neural networks replicated human neural patterns when stimulus information was preserved for network readout. Altogether, these findings help reconcile the long-standing debate in WM research, and provide empirical and computational evidence that flexible stimulus representation in the frontal cortex during WM serves as a potential neural coding scheme to accommodate the ever-changing environment.
Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses
Authors: Fang Yujie , Guan Zihan , Zhu Xiangtao , Guan Zhenqiong , Li Shufen , Peng Ke
Published: September 2024

Apoptosis has been recognized as a suicidal host-defense programmed cell death pathway against invading pathogens. However, recent evidences showed that viruses can employ caspases to cleave and inactivate immune signaling molecules to facilitate infection. Whether caspases can promote anti-viral immune responses is currently unknown. Here, we demonstrated that the NSs protein of RVFV triggers activation of apoptotic caspases, which cleave the mitochondrial fission factor DRP1 resulting in mitochondrial elongation. Elongated mitochondria promote MAVS aggregation leading to enhanced anti-viral immunity. Apoptotic caspases, including caspase-3, -6, -7 and -8, cleave DRP1 at the motifs of D
500
FAD
503
and/or AEAD
556
, suggesting that this cleavage event may occur during infection of different viruses. Indeed, infection of H1N1, SeV and HSV-1 all triggered apoptotic caspases activation to cleave DRP1 promoting anti-viral immune responses. Compared with wild-type DRP1, introduction of caspase-resistant DRP1 strongly attenuated immune responses triggered by virus infection. These results revealed a novel mechanism through which apoptotic caspases promote anti-viral immunity by regulating mitochondrial morphodynamics.