bluuebunny/crossref_metadata_2025 huggingface dataset:
Output-based measurement of accounting comparability: A survey of empirical proxies
Authors: Gross Christian , Perotti Pietro
Published: September 2017

Accounting comparability has been the subject of significant interest in empirical financial accounting research. Recent literature, particularly that following De Franco et al.’s (2011) influential study, has focused on utilizing the output of the financial reporting process to measure accounting comparability. In this paper, we conduct an early survey of studies using output-based measures of comparability. We provide two distinct contributions to the literature. First, we describe and comment on four important measurement concepts as well as the studies that introduced them. With this methodological contribution, we aim to facilitate the measurement choice for empirical accounting researchers engaged in comparability research. Second, we classify the sub-streams of literature and related studies. In providing this content-related contribution, we sum up what has already been achieved in output-based accounting comparability research and highlight potential areas for prospective research. As a whole, our study attempts to guide empirical researchers who (plan to) undertake studies on accounting comparability in selecting relevant topics and choosing adequate approaches to measurement.
Comparing Electrical Stimulation With and Without Ultrasound Guidance for Phenol Neurolysis to the Musculocutaneous Nerve
Authors: Matsumoto Mary E. , Berry Jessica , Yung Herbie , Matsumoto Martha , Munin Michael C.
Published: September 2017

Background

Ultrasound guidance is increasingly being used for neurolytic procedures that have traditionally been done with electrical stimulation (e‐stim) guidance alone. Ultrasound visualization with e‐stim−guided neurolysis can potentially allow adjustments in injection protocols that will reduce the volume of neurolytic agent needed to achieve clinical improvement.

Objective

This study compared e‐stim only to e‐stim with ultrasound guidance in phenol neurolysis of the musculocutaneous nerve (MCN) for elbow flexor spasticity. We also evaluated the ultrasound appearance of the MCN in this population.

Design

Retrospective review.

Setting

University hospital outpatient clinic.

Participants

Adults (N = 167) receiving phenol neurolysis to the MCN for treatment of elbow flexor spasticity between 1997 and 2014 and adult control subjects.

Methods

For each phenol injection of the MCN, the method of guidance, volume of phenol injected, technical success, improved range of motion at the elbow postinjection, adverse effects, reason for termination of injections, and details of concomitant botulinum toxin injection were recorded. The ultrasound appearance of the MCN, including nerve cross‐sectional area and shape, were recorded and compared between groups.

Main Outcome Measures

The volume of phenol injected and MCN cross‐sectional area and shape as demonstrated by ultrasound.

Results

The addition of ultrasound to e‐stim−guided phenol neurolysis was associated with lower doses of phenol when compared to e‐stim guidance alone (2.31 mL versus 3.69 mL, P < .001). With subsequent injections, the dose of phenol increased with e‐stim guidance (P < .001), but not with e‐stim and ultrasound guidance (P = .95). Both methods of guidance had high technical success, improved ROM at elbow postinjection, and low rates of adverse events. In comparing the ultrasound appearance of the MCN in patients with spasticity to that of normal controls, there was no difference in the cross‐sectional area of the nerve, but there was more variability in shape.

Conclusions

Combined e‐stim and ultrasound guidance during phenol neurolysis to the MCN allows a smaller volume of phenol to be used for equal effect, both at initial and repeat injection. The MCN shape was more variable in individuals with spasticity; this should be recognized so as to successfully locate the nerve to perform neurolysis.

Level of Evidence

IV
Radiation of internal waves from groups of surface gravity waves
Authors: Haney S. , Young W. R.
Published: September 2017

Groups of surface gravity waves induce horizontally varying Stokes drift that drives convergence of water ahead of the group and divergence behind. The mass flux divergence associated with spatially variable Stokes drift pumps water downwards in front of the group and upwards in the rear. This ‘Stokes pumping’ creates a deep Eulerian return flow that sets the isopycnals below the wave group in motion and generates a trailing wake of internal gravity waves. We compute the energy flux from surface to internal waves by finding solutions of the wave-averaged Boussinesq equations in two and three dimensions forced by Stokes pumping at the surface. The two-dimensional (2-D) case is distinct from the 3-D case in that the stratification must be very strong, or the surface waves very slow for any internal wave (IW) radiation at all. On the other hand, in three dimensions, IW radiation always occurs, but with a larger energy flux as the stratification and surface wave (SW) amplitude increase or as the SW period is shorter. Specifically, the energy flux from SWs to IWs varies as the fourth power of the SW amplitude and of the buoyancy frequency, and is inversely proportional to the fifth power of the SW period. Using parameters typical of short period swell (e.g. 8 s SW period with 1 m amplitude) we find that the energy flux is small compared to both the total energy in a typical SW group and compared to the total IW energy. Therefore this coupling between SWs and IWs is not a significant sink of energy for the SWs nor a source for IWs. In an extreme case (e.g. 4 m amplitude 20 s period SWs) this coupling is a significant source of energy for IWs with frequency close to the buoyancy frequency.
Circulation control in magnetohydrodynamic rotating flows
Authors: Borisevich V. D. , Potanin E. P. , Whichello J.
Published: September 2017

A model of a laminar viscous conducting flow, near a dielectric disc in a uniform magnetic field and in the presence of external rotation, is considered, where there is a uniform suction and an axial temperature gradient between the flow and the disc’s surface. It is assumed that the parameters of the suction or the magnetohydrodynamic (MHD) interaction are such that the nonlinear inertial terms, related to the circulation flow, are negligible in the differential equations of the MHD boundary layer on a rotating disc. Analysis of the motion and energy equations, taking the dependence of density on temperature into account, is carried out using the Dorodnitsyn transformation. The exact analytical solution for the boundary layer and heat transfer equations is obtained and analysed, neglecting the viscous and Joule dissipation. The dependence of the flow characteristics in the boundary layer on the rate of suction and the magnetic field induction is studied. It is shown that the direction of the radial flow in the boundary layer on a disc can be changed, not only by variation of the ratio between the angular velocities in the external flow and the boundary layer, but also by changing the ratio of the temperatures in these two flows, as well as by varying the hydrodynamic Prandtl number. The approximate calculation of a three-dimensional flow in a rotating cylinder with a braking disc (or lid) is carried out, demonstrating that a magnetic field slows the circulation velocity in a rotating cylinder.
Implicit renewal theory in the arithmetic case
Authors: Kevei Péter
Published: September 2017

We extend Goldie's implicit renewal theorem to the arithmetic case, which allows us to determine the tail behavior of the solution of various random fixed point equations. It turns out that the arithmetic and nonarithmetic cases are very different. Under appropriate conditions we obtain that the tail of the solution X of the fixed point equations X =DAX + B and X =DAX ∨ B is ℓ(x) q(x) x-κ, where q is a logarithmically periodic function q(x eh) = q(x), x > 0, with h being the span of the arithmetic distribution of log A, and ℓ is a slowly varying function. In particular, the tail is not necessarily regularly varying. We use the renewal theoretic approach developed by Grincevičius (1975) and Goldie (1991).
Marginal standardization of upper semicontinuous processes. With application to max-stable processes
Authors: Sabourin Anne , Segers Johan
Published: September 2017

Extreme value theory for random vectors and stochastic processes with continuous trajectories is usually formulated for random objects where the univariate marginal distributions are identical. In the spirit of Sklar's theorem from copula theory, such marginal standardization is carried out by the pointwise probability integral transform. Certain situations, however, call for stochastic models whose trajectories are not continuous but merely upper semicontinuous (USC). Unfortunately, the pointwise application of the probability integral transform to a USC process does not, in general, preserve the upper semicontinuity of the trajectories. In this paper we give sufficient conditions to enable marginal standardization of USC processes and we state a partial extension of Sklar's theorem for USC processes. We specialize the results to max-stable processes whose marginal distributions and normalizing sequences are allowed to vary with the coordinate.
Excursion sets of infinitely divisible random fields with convolution equivalent Lévy measure
Authors: Rønn-Nielsen Anders , Vedel Jensen Eva B.
Published: September 2017

We consider a continuous, infinitely divisible random field in ℝd, d = 1, 2, 3, given as an integral of a kernel function with respect to a Lévy basis with convolution equivalent Lévy measure. For a large class of such random fields, we compute the asymptotic probability that the excursion set at level x contains some rotation of an object with fixed radius as x → ∞. Our main result is that the asymptotic probability is equivalent to the right tail of the underlying Lévy measure.
On the outcome of epidemics with detections
Authors: Lefèvre Claude , Picard Philippe
Published: September 2017

The classical SIR epidemic model is generalized to incorporate a detection process of infectives in the course of time. Our purpose is to determine the exact distribution of the population state at the first detection instant and the following ones. An extension is also discussed that allows the parameters to change with the number of detected cases. The followed approach relies on simple martingale arguments and uses a special family of Abel–Gontcharoff polynomials.
Finite-pool queueing with heavy-tailed services
Authors: Bet Gianmarco , van der Hofstad Remco , van Leeuwaarden Johan S. H.
Published: September 2017

We consider the Δ(i)/G/1 queue, in which a total ofncustomers join a single-server queue for service. Customers join the queue independently after exponential times. We considerheavy-tailedservice-time distributions with tails decaying asx-α, α ∈ (1, 2). We consider the asymptotic regime in which the population size grows to ∞ and establish that the scaled queue-length process converges to an α-stable process with a negative quadratic drift. We leverage this asymptotic result to characterize the head start that is needed to create a long period of uninterrupted activity (a busy period). The heavy-tailed service times should be contrasted with the case of light-tailed service times, for which a similar scaling limit arises (Betet al.(2015)), but then with a Brownian motion instead of an α-stable process.
Rare events of transitory queues
Authors: Honnappa Harsha
Published: September 2017

We study the rare-event behavior of the workload process in a transitory queue, where the arrival epochs (or 'points') of a finite number of jobs are assumed to be the ordered statistics of independent and identically distributed (i.i.d.) random variables. The service times (or 'marks') of the jobs are assumed to be i.i.d. random variables with a general distribution, that are jointly independent of the arrival epochs. Under the assumption that the service times are strictly positive, we derive the large deviations principle (LDP) satisfied by the workload process. The analysis leverages the connection between ordered statistics and self-normalized sums of exponential random variables to establish the LDP. In this paper we present the first analysis of rare events in transitory queueing models, supplementing prior work that has focused on fluid and diffusion approximations.
Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12status compared with pregnant women of European ethnicity
Authors: Schroder Theresa H. , Sinclair Graham , Mattman Andre , Jung Benjamin , Barr Susan I. , Vallance Hilary D. , Lamers Yvonne
Published: September 2017

Maternal vitamin B12(B12) status has been inversely associated with adverse pregnancy outcomes and positively with fetal growth and infant development. South Asians, Canada’s largest ethnic minority, are prone to B12deficiency. Yet, data are lacking on B12status in South Asian pregnant women in North America. We sought to determine B12status, using multiple biomarkers, in 1st and 2nd trimester pregnant women of South Asian and, for comparison, European ethnicity living in Vancouver, Canada. In this retrospective cohort study, total B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine concentrations were quantified in two routinely collected (mean gestational week: 11·5 (range 8·3–13·9) and 16·5 (range 14·9–20·9)), banked serum samples of 748 healthy pregnant South Asian (n371) and European (n377) women. South Asian pregnant women had significantly lower B12status than European pregnant women at both time points, as indicated by lower serum total B12and holoTC concentrations, and higher MMA concentrations (allP≤0·001). The largest difference, which was substantial (Cohen’sd≥0·5), was observed in mean serum total B12concentrations (1st trimester: 189 (95 % CI 180, 199)v. 246 (95 % CI 236, 257) pmol/l; 2nd trimester: 176 (95 % CI 168, 185)v. 226 (95 % CI 216, 236) pmol/l). Further, South Asian ethnicity was a significant negative predictor of B12status during pregnancy. South Asian women living in Vancouver have substantially lower B12status during early pregnancy. Future research identifying predictors and health consequences of this observed difference is needed to allow for targeted interventions.
A review of the 0.1 reconnection rate problem
Authors: Cassak P. A. , Liu Y.-H. , Shay M. A.
Published: September 2017

A long-standing problem in magnetic reconnection is to explain why it tends to proceed at or below a normalized rate of 0.1. This article gives a review of observational and numerical evidence for this rate and discusses recent theoretical work addressing this problem. Some remaining open questions are summarized.
Emerging treatments for the behavioral and psychological symptoms of dementia
Authors: Anand Abhinav , Khurana Puneet , Chawla Jasneet , Sharma Neha , Khurana Navneet
Published: September 2017

Dementia is referred to a loss of memory and decline in other mental abilities at levels critical enough to hinder performance of daily activities. It can be of several types, depending on the underlying pathophysiology. The behavioral and psychological symptoms of dementia (BPSD) are various, but the most clinically significant are depression, apathy, and anxiety. Other BPSD include agitation, aberrant motor behavior, elation, hallucinations, and alterations in sleep and appetite. About 90% of sufferers of dementia are affected by BPSD during the course of the illness. These symptoms occur in demented patients irrespective of the dementia subtype. However, there has not been significant development in the areas of disease-modifying pharmacotherapeutics for dementia. Therefore, tackling BPSD has emerged as a research avenue in the recent past. Existing antidepressants, antipsychotics, and cholinergic agents have been extensively used in the treatment of BPSD, independently and in different combinations. However, these agents have not successful in completely alleviating such symptoms. Research in this field is going on globally, but it is still limited by various factors. There is a strong need to develop new entities and test them clinically. This review focuses on emerging treatments for the management of clinically significant BPSD.
Relationship between Cognitive Performance and Measures of Neurodegeneration among Hispanic and White Non-Hispanic Individuals with Normal Cognition, Mild Cognitive Impairment, and Dementia
Authors: Burke Shanna L. , Rodriguez Miriam J. , Barker Warren , Greig-Custo Maria T , Rosselli Monica , Loewenstein David A. , Duara Ranjan
Published: September 2017

Objectives:The aim of this study was to determine the presence and severity of potential cultural and language bias in widely used cognitive and other assessment instruments, using structural MRI measures of neurodegeneration as biomarkers of disease stage and severity.Methods:Hispanic (n=75) and White non-Hispanic (WNH) (n=90) subjects were classified as cognitively normal (CN), amnestic mild cognitive impairment (aMCI) and mild dementia. Performance on the culture-fair and educationally fair Fuld Object Memory Evaluation (FOME) and Clinical Dementia Rating Scale (CDR) between Hispanics and WNHs was equivalent, in each diagnostic group. Volumetric and visually rated measures of the hippocampus entorhinal cortex, and inferior lateral ventricles (ILV) were measured on structural MRI scans for all subjects. A series of analyses of covariance, controlling for age, depression, and education, were conducted to compare the level of neurodegeneration on these MRI measures between Hispanics and WNHs in each diagnostic group.Results:Among both Hispanics and WNH groups there was a progressive decrease in volume of the hippocampus and entorhinal cortex, and an increase in volume of the ILV (indicating increasing atrophy in the regions surrounding the ILV) from CN to aMCI to mild dementia. For equivalent levels of performance on the FOME and CDR, WNHs had greater levels of neurodegeneration than did Hispanic subjects.Conclusions:Atrophy in medial temporal regions was found to be greater among WNH than Hispanic diagnostic groups, despite the lack of statistical differences in cognitive performance between these two ethnic groups. Presumably, unmeasured factors result in better cognitive performance among WNH than Hispanics for a given level of neurodegeneration. (JINS, 2018,24, 176–187)
Three-Dimensional (3D) Nanometrology Based on Scanning Electron Microscope (SEM) Stereophotogrammetry
Authors: Tondare Vipin N. , Villarrubia John S. , Vladár András E.
Published: September 2017

Three-dimensional (3D) reconstruction of a sample surface from scanning electron microscope (SEM) images taken at two perspectives has been known for decades. Nowadays, there exist several commercially available stereophotogrammetry software packages. For testing these software packages, in this study we used Monte Carlo simulated SEM images of virtual samples. A virtual sample is a model in a computer, and its true dimensions are known exactly, which is impossible for real SEM samples due to measurement uncertainty. The simulated SEM images can be used for algorithm testing, development, and validation. We tested two stereophotogrammetry software packages and compared their reconstructed 3D models with the known geometry of the virtual samples used to create the simulated SEM images. Both packages performed relatively well with simulated SEM images of a sample with a rough surface. However, in a sample containing nearly uniform and therefore low-contrast zones, the height reconstruction error was ≈46%. The present stereophotogrammetry software packages need further improvement before they can be used reliably with SEM images with uniform zones.
Depressed Multiple-Suicide­Attempters – A High-Risk Phenotype
Authors: Sher Leo , Grunebaum Michael F. , Burke Ainsley K. , Chaudhury Sadia , Mann J. John , Oquendo Maria A.
Published: September 2017

Abstract. Background: There is compelling evidence that suicide attempts are among the strongest predictors of suicide and future suicide attempts. Aim: This study aimed to examine psychopathology in multiple-suicide attempters. Method: We compared the demographic and clinical features of three groups: depressed patients without a history of suicide attempts (non-attempters), depressed patients with a history of one to three suicide attempts (attempters), and depressed patients with a history of four or more suicide attempts (multiple attempters). Results: We found that attempters and multiple attempters had higher levels of depression, hopelessness, aggression, hostility, and impulsivity and were more likely to have borderline personality disorder and family history of major depression or alcohol use disorder compared with non-attempters, but did not differ between each other on these measures. Multiple attempters had greater suicidal ideation at study entry and were more likely to have family history of suicide attempt compared with attempters. Importantly, multiple attempters had greater suicide intent at the time of the most medically serious suicide attempt and more serious medical consequences during their most medically serious suicide attempt compared with attempters. Limitations: The cross-sectional design of the study. Conclusion: Our data suggest that multiple-suicide attempters require careful evaluation as their behavior can have serious medical consequences.
Deepwater Horizon Dispersant Cleared the Air, New Model Shows
Authors: Kaufman Rachel
Published: September 2017

A simulation of oil and gas leakage during the Deepwater Horizon disaster finds that the main chemical dispersant used improved air quality for emergency responders.
Unusual interlayer quantum transport behavior caused by the zeroth Landau level in YbMnBi2
Authors: Liu J. Y. , Hu J. , Graf D. , Zou T. , Zhu M. , Shi Y. , Che S. , Radmanesh S. M. A. , Lau C. N. , Spinu L. , Cao H. B. , Ke X. , Mao Z. Q.
Published: September 2017

Relativistic fermions in topological quantum materials are characterized by linear energy–momentum dispersion near band crossing points. Under magnetic fields, relativistic fermions acquire Berry phase of π in cyclotron motion, leading to a zeroth Landau level (LL) at the crossing point, a signature unique to relativistic fermions. Here we report the unusual interlayer quantum transport behavior resulting from the zeroth LL mode observed in the time reversal symmetry breaking type II Weyl semimetal YbMnBi2. The interlayer magnetoresistivity and Hall conductivity of this material are found to exhibit surprising angular dependences under high fields, which can be well fitted by a model, which considers the interlayer quantum tunneling transport of the zeroth LL's Weyl fermions. Our results shed light on the unusual role of zeroth LLl mode in transport.
Sequence-controlled supramolecular terpolymerization directed by specific molecular recognitions
Authors: Hirao Takehiro , Kudo Hiroaki , Amimoto Tomoko , Haino Takeharu
Published: September 2017

Nature precisely manipulates primary monomer sequences in biopolymers. In synthetic polymer sequences, this precision has been limited because of the lack of polymerization techniques for conventional polymer synthesis. Engineering the primary monomer sequence of a polymer main chain represents a considerable challenge in polymer science. Here, we report the development of sequence-controlled supramolecular terpolymerization via a self-sorting behavior among three sets of monomers possessing mismatched host–guest pairs. Complementary biscalix[5]arene-C60, bisporphyrin-trinitrofluorenone (TNF), and Hamilton’s bis(acetamidopyridinyl)isophthalamide-barbiturate hydrogen-bonding host–guest complexes are separately incorporated into heteroditopic monomers that then generate an ABC sequence-controlled supramolecular terpolymer. The polymeric nature of the supramolecular terpolymer is confirmed in both solution and solid states. Our synthetic methodology may pave an avenue for constructing polymers with tailored sequences that are associated with advanced functions.
Interlayer excitons in a bulk van der Waals semiconductor
Authors: Arora Ashish , Drüppel Matthias , Schmidt Robert , Deilmann Thorsten , Schneider Robert , Molas Maciej R. , Marauhn Philipp , Michaelis de Vasconcellos Steffen , Potemski Marek , Rohlfing Michael , Bratschitsch Rudolf
Published: September 2017

Bound electron–hole pairs called excitons govern the electronic and optical response of many organic and inorganic semiconductors. Excitons with spatially displaced wave functions of electrons and holes (interlayer excitons) are important for Bose–Einstein condensation, superfluidity, dissipationless current flow, and the light-induced exciton spin Hall effect. Here we report on the discovery of interlayer excitons in a bulk van der Waals semiconductor. They form due to strong localization and spin-valley coupling of charge carriers. By combining high-field magneto-reflectance experiments and ab initio calculations for 2H-MoTe2, we explain their salient features: the positive sign of the g-factor and the large diamagnetic shift. Our investigations solve the long-standing puzzle of positive g-factors in transition metal dichalcogenides, and pave the way for studying collective phenomena in these materials at elevated temperatures.
IgG1 memory B cells keep the memory of IgE responses
Authors: He Jin-Shu , Subramaniam Sharrada , Narang Vipin , Srinivasan Kandhadayar , Saunders Sean P. , Carbajo Daniel , Wen-Shan Tsao , Hidayah Hamadee Nur , Lum Josephine , Lee Andrea , Chen Jinmiao , Poidinger Michael , Zolezzi Francesca , Lafaille Juan J. , Curotto de Lafaille Maria A.
Published: September 2017

The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B cells in IgE production and find that two subsets of IgG1 memory B cells, CD80+CD73+and CD80−CD73−, contribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE. Furthermore, repertoire analysis indicates that high affinity IgE and IgG1 plasma cells differentiate from rare CD80+CD73+high affinity memory clones without undergoing further mutagenesis. By identifying the cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate, our findings provide fundamental insights into the pathogenesis of allergies, and on the mechanisms of antibody production in memory B cell responses.
Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction
Authors: Lee Hsiang-Chun , Chen Chih-Chieh , Tsai Wei-Chung , Lin Hsin-Ting , Shiao Yi-Lin , Sheu Sheng-Hsiung , Wu Bin-Nan , Chen Chu-Huang , Lai Wen-Ter
Published: September 2017

Very-low-density lipoproteins (VLDL) is a hallmark of metabolic syndrome (MetS) and each manifestation of MetS is related to atrial fibrillation (AF) risks. Slowed atrial conduction is a mechanism of AF in MetS. We hypothesized that VLDL can modulate and reduce atrial gap junctions. VLDLs were separated from normal (Normal-VLDL) and MetS (MetS-VLDL) individuals. VLDLs (15 µg/g) and equivalent volumes of saline (CTL) were injected respectively to C57BL/6 mice for 6 weeks. Electrocardiograms demonstrated that MetS-VLDL induced prolongation of P wave (P = 0.041), PR intervals (P = 0.014), QRS duration and QTc interval (both P = 0.003), but Normal-VLDL did not. Optical mapping of perfused hearts confirmed slowed conduction on atria and ventricles of MetS-VLDL mice. Slowed cardiac conduction was associated with significant atrial and ventricular remodeling, along with systolic dysfunction and comparable intra-cardiac fibrosis. MetS-VLDL induced downregulation of Cx40 and Cx43 at transcriptional, translational and tissue levels, and it also enhanced O-GlcNAcylation of Cx40 and Cx43. Protein structure analyses predicted O-GlcNAcylation at serine 18 of Cx40 and Cx43 which may impair stability of gap junctions. In conclusion, MetS-VLDL modulates gap junctions and delays both atrial and ventricular conduction. VLDL may contribute to the pathophysiology of atrial fibrillation and ventricular arrhythmias in MetS.
Microfluidic manipulation of magnetic flux domains in type-I superconductors: droplet formation, fusion and fission
Authors: Berdiyorov G. R. , Milošević M. V. , Hernández-Nieves A. D. , Peeters F. M. , Domínguez D.
Published: September 2017

The magnetic flux domains in the intermediate state of type-I superconductors are known to resemble fluid droplets, and their dynamics in applied electric current is often cartooned as a “dripping faucet”. Here we show, using the time-depended Ginzburg-Landau simulations, that microfluidic principles hold also for the determination of the size of the magnetic flux-droplet as a function of the applied current, as well as for the merger or splitting of those droplets in the presence of the nanoengineered obstacles for droplet motion. Differently from fluids, the flux-droplets in superconductors are quantized and dissipative objects, and their pinning/depinning, nucleation, and splitting occur in a discretized form, all traceable in the voltage measured across the sample. At larger applied currents, we demonstrate how obstacles can cause branching of laminar flux streams or their transformation into mobile droplets, as readily observed in experiments.
Importance of time in therapeutic range on bleeding risk prediction using clinical risk scores in patients with atrial fibrillation
Authors: Rivera-Caravaca José Miguel , Roldán Vanessa , Esteve-Pastor María Asunción , Valdés Mariano , Vicente Vicente , Lip Gregory Y. H. , Marín Francisco
Published: September 2017

Bleeding risk with vitamin K antagonists (VKAs) is closely related to the quality of anticoagulation in atrial fibrillation (AF) patients, reflected by time in therapeutic range (TTR). Here we compared the discrimination performance of different bleeding risk scores and investigated if adding TTR would improve their predictive value and clinical usefulness. We included 1361 AF patients stables on VKA for at least 6 months. Bleeding risk was assessed by the HAS-BLED, ATRIA, ORBIT and HEMORR2HAGES scores. Major bleeding events were recorded after a median of 6.5 years follow-up. In this period 250 patients suffered major bleeds. Comparison of receiver operating characteristic (ROC) curves demonstrated that HAS-BLED had the best discrimination performance, but adding the ‘labile INR’ criteria (i.e. TTR <65%) to ATRIA, ORBIT and HEMORR2HAGES increased their ability of discrimination and predictive value, with significant improvements in reclassification and discriminatory performance. Decision curve analyses (DCA) showed improvements of the clinical usefulness and a net benefit of the modified risk scores. In summary, in AF patients taking VKAs, the HAS-BLED score had the best predictive ability. Adding ‘labile INR’ to ATRIA, ORBIT and HEMORR2HAGES improved their predictive value for major bleeding leading to improved clinical usefulness compared to the original scores.
High levels of ammonia do not raise fine particle pH sufficiently to yield nitrogen oxide-dominated sulfate production
Authors: Guo Hongyu , Weber Rodney J. , Nenes Athanasios
Published: September 2017

High levels of ammonia (NH3) have been suggested to elevate ambient particle pH levels to near neutral acidity (pH = 7), a condition that promotes rapid SO2 oxidation by NO2 to form aerosol sulfate concentration consistent with “London fog” levels. This postulation is tested using aerosol data from representative sites around the world to conduct a thorough thermodynamic analysis of aerosol pH and its sensitivity to NH3 levels. We find that particle pH, regardless of ammonia levels, is always acidic even for the unusually high NH3 levels found in Beijing (pH = 4.5) and Xi’an (pH = 5), locations where sulfate production from NO
x
is proposed. Therefore, major sulfate oxidation through a NO2-mediated pathway is not likely in China, or any other region of the world (e.g., US, Mediterranean) where the aerosol is consistently more acidic. The limited alkalinity from the carbonate buffer in dust and seasalt can provide the only likely set of conditions where NO2-mediated oxidation of SO2 outcompetes with other well-established pathways. The mildly acidic levels associated with excessive amounts of ammonia can promote high rates of SO2 oxidation through transition metal chemistry, this may be an alternative important aerosol chemical contributor to the extreme pollution events.
Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis
Authors: Domaszewska Teresa , Scheuermann Lisa , Hahnke Karin , Mollenkopf Hans , Dorhoi Anca , Kaufmann Stefan H. E. , Weiner January
Published: September 2017

Immunity in infection, inflammation and malignancy differs markedly in man and mouse. Still, we learn about human immunity in large extent from experimental mouse models. We propose a novel data integration approach which identifies concordant and discordant gene expression patterns of the immune responses in heterologous data sets. We have conducted experiments to compare human and murine transcriptional responses to Mycobacterium tuberculosis (Mtb) infection in whole blood (WB) as well as macrophages and compared them with simulated as well as publicly available data. Our results indicate profound differences between patterns of gene expression in innate and adaptive immunity in man and mouse upon Mtb infection. We characterized differential expression of T-cell related genes corresponding to the differences in phenotype between tuberculosis (TB) highly and low susceptible mouse strains. Our approach is general and facilitates the choice of optimal animal model for studies of the human immune response to a particular disease.
Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins
Authors: Chabert Clovis , Khochbin Saadi , Rousseaux Sophie , Furze Rebecca , Smithers Nicholas , Prinjha Rab , Schlattner Uwe , Pison Christophe , Dubouchaud Hervé
Published: September 2017

Some of the Chronic Obstructive Pulmonary Disease (COPD) patients engaged in exercise-based muscle rehabilitation programs are unresponsive. To unravel the respective role of chronic hypoxia and pulmonary inflammation on soleus muscle hypertrophic capacities, we challenged male Wistar rats to repeated lipopolysaccharide instillations, associated or not with a chronic hypoxia exposure. Muscle hypertrophy was initiated by bilateral ablation of soleus agonists 1 week before sacrifice. To understand the role played by the histone acetylation, we also treated our animals with an inhibitor of bromodomains and extra terminal proteins (I-BET) during the week after surgery. Pulmonary inflammation totally inhibited this hypertrophy response under both normoxic and hypoxic conditions (26% lower than control surgery, p < 0.05), consistent with the S6K1 and myogenin measurements. Changes in histone acetylation and class IIa histone deacetylases expression, following pulmonary inflammation, suggested a putative role for histone acetylation signaling in the altered hypertrophy response. The I-BET drug restored the hypertrophy response suggesting that the non-response of muscle to a hypertrophic stimulus could be modulated by epigenetic mechanisms, including histone-acetylation dependant pathways. Drugs targeting such epigenetic mechanisms may open therapeutic perspectives for COPD patients with systemic inflammation who are unresponsive to rehabilitation.
MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis
Authors: Chen Heming , Li Xiaoyi , Liu Shuiyi , Gu Lu , Zhou Xinmin
Published: September 2017

Atherosclerosis, a serious threat to human cardiovascular health, involves inflammation throughout its various stages of development. MicroRNAs play an important regulatory role in macrophages that respond to inflammation, but the underlying mechanisms are largely unknown. In this work, we study the impact of miR-19a in macrophage-derived foam cell formation during atherogenesis. A microarray-based analysis of serums from patients with coronary heart disease in comparison with healthy controls reveals a significant enrichment of miR-19a in the serums of atherosclerosis patients. A higher level of miR-19a is also observed in atherosclerosis-prone ascending aortic wall tissues than in internal mammary artery amongst patients with coronary heart disease. We identify HMG-Box Transcription Factor 1 (HBP-1) as a target gene of miR-19a. HBP1 is repressor of macrophage migration inhibiting factor (MIF) and overexpression of miR-19a increases MIF expression. By administering a miR-19a antagonist to the caudal vein, we found a decrease in atherosclerotic plaques and lipids load in apoE-null mice fed with high-fat diet. These results support inhibition of miR-19a reduces inflammatory reaction and constitutes a potent therapeutic approach against atherosclerosis.
Location of Cerebral Microbleeds And Their Association with Carotid Intima-media Thickness: A Community-based Study
Authors: Chung Chih-Ping , Chou Kun-Hsien , Chen Wei-Ta , Liu Li-Kuo , Lee Wei-Ju , Huang An-Chun , Chen Liang-Kung , Lin Ching-Po , Wang Pei-Ning
Published: September 2017

To assess whether high cerebral microbleeds (CMBs) are associated with carotid intima-media thickness (CIMT), a marker of systemic atherosclerosis, we cross-sectionally evaluated participants from a community-based study, the I-Lan Longitudinal Aging Study. The participants’ demographics and cardiovascular risk factors were determined by questionnaire and/or laboratory measurements. CIMT was measured by ultrasonography. CMBs were assessed by susceptibility-weighted-imaging on 3 T MRI. Of the 962 subjects [62.5(8.6) years, 44.2% men] included, CMBs were found in 134(14.0%) subjects. Among the subjects with identified CMB’s, 85(63.4%) had deep or infratentorial (DI) and 49(36.6%) had strictly lobar(SL) CMBs. After the results were adjusted for age and sex, the analysis revealed that hypertension, hyperlipidemia, obesity, and higher triglyceride levels correlated with DI but not SL CMBs. The subjects with DI CMBs also had a higher mean CIMT and higher prevalence of top quartile CIMT. The multivariate analysis demonstrated that high CIMT (top quartile) significantly predicted the presence of DI CMBs (odds ratio = 2.1; 95% confidence interval = 1.3–3.4; P = 0.004), independent of age, sex, cardiovascular risk factors, and other cerebral small vessel diseases, lacune, and white matter hyperintensity. There was no association between CIMT and SL CMBs. Our results support that there are distinct pathogenesis in DI and SL CMBs.
Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells
Authors: Vahedi Fatemeh , Nham Tina , Poznanski Sophie M. , Chew Marianne V. , Shenouda Mira M. , Lee Dean , Ashkar Ali A.
Published: September 2017

Adoptive immune cell therapy is emerging as a promising immunotherapy for cancer. Particularly, the adoptive transfer of NK cells has garnered attention due to their natural cytotoxicity against tumor cells and safety upon adoptive transfer to patients. Although strategies exist to efficiently generate large quantities of expanded NK cells ex vivo, it remains unknown whether these expanded NK cells can persist and/or proliferate in vivo in the absence of exogenous human cytokines. Here, we have examined the adoptive transfer of ex vivo expanded human cord blood-derived NK cells into humanized mice reconstituted with autologous human cord blood immune cells. We report that ex vivo expanded NK cells are able to survive and possibly proliferate in vivo in humanized mice without exogenous cytokine administration, but not in control mice that lack human immune cells. These findings demonstrate that the presence of autologous human immune cells supports the in vivo survival of ex vivo expanded human NK cells. These results support the application of ex vivo expanded NK cells in cancer immunotherapy and provide a translational humanized mouse model to test the lifespan, safety, and functionality of adoptively transferred cells in the presence of autologous human immune cells prior to clinical use.
S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells
Authors: Zhang Jinhua , Jiao Ying , Hou Shasha , Tian Tian , Yuan Qi , Hao Huaijie , Wu Zhenlong , Bao Xuexiang
Published: September 2017

S100A4 has been implicated in cancer and several inflammatory diseases, but its role in inflammatory bowel disease has not been well investigated. Here, upon infection with Citrobacter rodentium, a model for enteropathogenic Escherichia coli infection in humans, induced the infiltration of a large number of S100A4+ cells into the colon in wild type (WT) mice. Deficiency of S100A4 reduced weight loss, bacterial colonization and colonic pathology. Furthermore, the expression of inflammatory cytokines and the recruitment of macrophages and neutrophils also decreased significantly in S100A4 knock out (S100A4−/−) mice. In vitro, soluble S100A4 directly up-regulated expression of integrin β−1 in intestinal epithelial cells and significantly increased the adherence of C. rodentium to intestinal epithelial cells. Additionally, the effects of S100A4 on the adherence of C. rodentium to epithelial cells could be abolished by a receptor for advanced glycation end products (RAGE)-specific inhibitor (FPS-ZM1). Therefore, these data indicate a novel mechanism for S100A4 that promotes colitis development by enhancing host adhesion and colonization of Citrobacter rodentium through the S100A4-mediated host inflammatory responses.
Polystyrene nanoplastics inhibit reproduction and induce abnormal embryonic development in the freshwater crustacean Daphnia galeata
Authors: Cui Rongxue , Kim Shin Woong , An Youn-Joo
Published: September 2017

We assayed the toxicity of polystyrene nanoparticles (PS-NP, 52 nm) to Daphnia galeata. Survival and reproduction were significantly decreased in individuals exposed to 5 mg/L of PS-NP for 5 days, and embryos showed abnormal development, including a low hatching rate. Using fluorescence confocal microscopy, we recorded the transfer of PS-NP from the external surface of the body to the internal organs, including the thoracic appendices, ovaries, caudal appendices, and brood chamber, as well as PS-NP storage in lipid droplets. Although embryos were exposed to PS-NP in the brood chamber, they did not internalize PS-NP. Exposed D. galeata adults that were not pregnant stored significantly fewer lipid droplets than did the control group, and the lipid droplets that they did store were smaller; meanwhile, there were no significant changes in lipid storage in exposed pregnant individuals. Some embryos showed a high level of lipid storage, a response that occurs when embryos experience an abnormal state, and these embryos showed a very low hatching rate. However, the offspring of exposed adults showed normal survival and lipid storage. This study provides visual evidence that confirms the transfer and effects of PS-NP in Daphnia species, and suggests a relationship between toxicity and lipid storage.
Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder
Authors: Hnoonual Areerat , Thammachote Weerin , Tim-Aroon Thipwimol , Rojnueangnit Kitiwan , Hansakunachai Tippawan , Sombuntham Tasanawat , Roongpraiwan Rawiwan , Worachotekamjorn Juthamas , Chuthapisith Jariya , Fucharoen Suthat , Wattanasirichaigoon Duangrurdee , Ruangdaraganon Nichara , Limprasert Pornprot , Jinawath Natini
Published: September 2017

Chromosomal microarray (CMA) is now recognized as the first-tier genetic test for detection of copy number variations (CNVs) in patients with autism spectrum disorder (ASD). The aims of this study were to identify known and novel ASD associated-CNVs and to evaluate the diagnostic yield of CMA in Thai patients with ASD. The Infinium CytoSNP-850K BeadChip was used to detect CNVs in 114 Thai patients comprised of 68 retrospective ASD patients (group 1) with the use of CMA as a second line test and 46 prospective ASD and developmental delay patients (group 2) with the use of CMA as the first-tier test. We identified 7 (6.1%) pathogenic CNVs and 22 (19.3%) variants of uncertain clinical significance (VOUS). A total of 29 patients with pathogenic CNVs and VOUS were found in 22% (15/68) and 30.4% (14/46) of the patients in groups 1 and 2, respectively. The difference in detected CNV frequencies between the 2 groups was not statistically significant (Chi square = 1.02, df = 1, P = 0.31). In addition, we propose one novel ASD candidate gene, SERINC2, which warrants further investigation. Our findings provide supportive evidence that CMA studies using population-specific reference databases in underrepresented populations are useful for identification of novel candidate genes.
Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice
Authors: Korshunov Vyacheslav A. , Wang Hexuan , Ahmed Rifat , Mickelsen Deanne M. , Zhou Qian , Yan Chen , Doyley Marvin M.
Published: September 2017

Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice. However, ultrasound could not detect differences in the carotid wall even at 2 weeks post-surgery. The Young’s modulus was measured based on displacements of the carotid artery wall, and Young’s modulus was 2-fold greater in shams at 1 week post ligation, and 3-fold greater 2 weeks after ligation. Finally, the higher Young’s modulus was most associated with higher intimal thickness but not medial or adventitial thickness as measured by histology. In conclusion, we developed a robust ultrasound-based elastography method for early detection of intimal changes in small animals.
A distributional multivariate approach for assessing performance of climate-hydrology models
Authors: Vezzoli Renata , Salvadori Gianfausto , De Michele Carlo
Published: September 2017

One of the ultimate goals of climate studies is to provide projections of future scenarios: for this purpose, sophisticated models are conceived, involving lots of parameters calibrated via observed data. The outputs of such models are used to investigate the impacts on related phenomena such as floods, droughts, etc. To evaluate the performance of such models, statistics like moments/quantiles are used, and comparisons with historical data are carried out. However, this may not be enough: correct estimates of some moments/quantiles do not imply that the probability distributions of observed and simulated data match. In this work, a distributional multivariate approach is outlined, also accounting for the fact that climate variables are often dependent. Suitable statistical tests are described, providing a non-parametric assessment exploiting the Copula Theory. These procedures allow to understand (i) whether the models are able to reproduce the distributional features of the observations, and (ii) how the models perform (e.g., in terms of future climate projections and changes). The proposed methodological approach is appropriate also in contexts different from climate studies, to evaluate the performance of any model of interest: methods to check a model per se are sketched out, investigating whether its outcomes are (statistically) consistent.