bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal Pattern of Carbon Compensation Potential and Network Association in Urban Agglomerations in the Yellow River Basin
Authors: Song Haihong , Li Yifan , Gu Liyuan , Tang Jingnan , Zhang Xin
Published: October 2023

The Yellow River Basin is an important energy base and economic belt in China, but its water resources are scarce, its ecology is fragile, and the task of achieving the goal of carbon peak and carbon neutrality is arduous. Carbon compensation potential can also be used to study the path to achieving carbon neutrality, which can clarify the potential of one region’s carbon sink surplus to be compensated to the other areas. Still, there needs to be more research on the carbon compensation potential of the Yellow River Basin. Therefore, this study calculated the carbon compensation potential using the β convergence test and parameter comparison method. With the help of spatial measurement tools such as GIS, GeoDa, Stata, and social network analysis methods, the spatiotemporal pattern and network structure of the carbon compensation potential in the Yellow River Basin were studied from the perspective of urban agglomeration. The results demonstrate the following: (1) The overall carbon compensation rate of the YRB showed a downward trend from 2005 to 2019, falling by 0.94, and the specific pattern was “high in the northwest and low in the southeast”. The spatial distribution is roughly spread along the east–west axis, and the distribution axis and the center of gravity keep shifting to the northwest. It also showed a weak divergence and a bifurcation trend. (2) The carbon compensation rate in the YRB passed the spatial correlation and β convergence tests, demonstrating the existence of spatial correlation and a “catch-up effect” among cities. (3) The overall distribution pattern of the carbon compensation potential in the YRB is a “low in the west and high in the east” pattern, and its value increased by 8.86% during the sampled period. (4) The network correlation of carbon compensation potential in the YRB has been significantly enhanced, with the downstream region being more connected than the upstream region. (5) The Shandong Peninsula Urban Agglomeration has the largest network center, followed by the Central Plains Urban Agglomeration, and the Ningxia along the Yellow River Urban Agglomeration has the fewest linked conduction paths. According to the research results, accurate and efficient planning and development suggestions are proposed for urban agglomeration in the Yellow River Basin.
H-Dot Mediated Nanotherapeutics Mitigate Systemic Toxicity of Platinum-Based Anticancer Drugs
Authors: Yamashita Atsushi , Park Seung Hun , Zeng Lingxue , Stiles Wesley R. , Ahn Sung , Bao Kai , Kim Jonghan , Kang Homan , Choi Hak Soo
Published: October 2023

Platinum-based anticancer agents have revolutionized oncological treatments globally. However, their therapeutic efficacy is often accompanied by systemic toxicity. Carboplatin, recognized for its relatively lower toxicity profile than cisplatin, still presents off-target toxicities, including dose-dependent cardiotoxicity, neurotoxicity, and myelosuppression. In this study, we demonstrate a delivery strategy of carboplatin to mitigate its off-target toxicity by leveraging the potential of zwitterionic nanocarrier, H-dot. The designed carboplatin/H-dot complex (Car/H-dot) exhibits rapid drug release kinetics and notable accumulation in proximity to tumor sites, indicative of amplified tumor targeting precision. Intriguingly, the Car/H-dot shows remarkable efficacy in eliminating tumors across insulinoma animal models. Encouragingly, concerns linked to carboplatin-induced cardiotoxicity are effectively alleviated by adopting the Car/H-dot nanotherapeutic approach. This pioneering investigation not only underscores the viability of H-dot as an organic nanocarrier for platinum drugs but also emphasizes its pivotal role in ameliorating associated toxicities. Thus, this study heralds a promising advancement in refining the therapeutic landscape of platinum-based chemotherapy.
Erdheim–Chester Disease Due to a Novel Internal Duplication of NRAS: Response to Targeted Therapy with Cobimetinib
Authors: Riancho José A. , Hernández José L. , González-Vela Carmen , López-Sundh Ana E. , González-Lopez Marcos A. , Gomez de la Fuente Francisco , Quirce Remedios , Diamond Eli L.
Published: October 2023

Histiocytoses encompass a group of exceptionally rare disorders characterized by the abnormal infiltration of tissues by histocytes. Among these, Erdheim–Chester disease (ECD) stands out as a multisystem histiocytosis that typically affects bones and various other tissues. Historically, the treatment of ECD has been challenging. However, recent breakthroughs in our understanding, particularly the discovery of somatic mutations in the RAS-MAPK pathway, have opened new opportunities for targeted therapy in a significant subset of patients with ECD and other histiocytoses. In this report, we present the case of a patient with ECD harboring a previously unidentified microduplication in the NRAS gene in a small fraction of skin cells. This discovery played a pivotal role in tailoring an effective therapeutic approach involving kinase inhibitors downstream of NRAS. This case underscores the crucial role of deep sequencing of tissue samples in ECD, enabling the delivery of personalized targeted therapy to patients.
The Communication from Immune Cells to the Fibroblasts in Keloids: Implications for Immunotherapy
Authors: Zhang Xiya , Wu Xinfeng , Li Dongqing
Published: October 2023

Keloids are a type of fibrotic disease characterized by excessive collagen production and extracellular matrix (ECM) deposition. The symptoms of pain and itching and frequent recurrence after treatment significantly impact the quality of life and mental health of patients. A deeper understanding of the pathogenesis of keloids is crucial for the development of an effective therapeutic approach. Fibroblasts play a central role in the pathogenesis of keloids by producing large amounts of collagen fibers. Recent evidence indicates that keloids exhibit high immune cell infiltration, and these cells secrete cytokines or growth factors to support keloid fibroblast proliferation. This article provides an update on the knowledge regarding the keloid microenvironment based on recent single-cell sequencing literature. Many inflammatory cells gathered in keloid lesions, such as macrophages, mast cells, and T lymphocytes, indicate that keloids may be an inflammatory skin disease. In this review, we focus on the communication from immune cells to the fibroblasts and the potential of immunotherapy for keloids. We hope that this review will trigger interest in investigating keloids as an inflammatory disease, which may open up new avenues for drug development by targeting immune mediators.
The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art
Authors: Argano Christiano , Mirarchi Luigi , Amodeo Simona , Orlando Valentina , Torres Alessandra , Corrao Salvatore
Published: October 2023

In the last decade, an increasing awareness was directed to the role of Vitamin D in non-skeletal and preventive roles for chronic diseases. Vitamin D is an essential hormone in regulating calcium/phosphorous balance and in the pathogenesis of inflammation, insulin resistance, and obesity. The main forms of vitamin D, Cholecalciferol (Vitamin D3) and Ergocalciferol (Vitamin D2) are converted into the active form (1,25-dihydroxyvitamin D) thanks to two hydroxylations in the liver, kidney, pancreas, and immune cells. Some anti-inflammatory cytokines are produced at higher levels by vitamin D, while some pro-inflammatory cytokines are released at lower levels. Toll-Like Receptor (TLR) expression is increased, and a pro-inflammatory state is also linked to low levels of vitamin D. Regardless of how it affects inflammation, various pathways suggest that vitamin D directly improves insulin sensitivity and secretion. The level of vitamin D in the body may change the ratio of pro- to anti-inflammatory cytokines, which would impact insulin action, lipid metabolism, and the development and function of adipose tissue. Many studies have demonstrated an inverse relationship between vitamin D concentrations and pro-inflammatory markers, insulin resistance, glucose intolerance, metabolic syndrome, obesity, and cardiovascular disease. It is interesting to note that several long-term studies also revealed an inverse correlation between vitamin D levels and the occurrence of diabetes mellitus. Vitamin D supplementation in people has controversial effects. While some studies demonstrated improvements in insulin sensitivity, glucose, and lipid metabolism, others revealed no significant effect on glycemic homeostasis and inflammation. This review aims to provide insight into the molecular basis of the relationship between vitamin D, insulin resistance, metabolic syndrome, type 1 and 2 diabetes, gestational diabetes, and cardiovascular diseases.
Habitat Characteristics of Camellia quephongensis and Adaptation Mechanisms in Que Phong District, North-Central Vietnam
Authors: Tran Tuyen Thi , Takahashi Kazuya , Nishikawa Hiroaki , Tanabe Reiko , Nguyen Trang Thanh Thi , Nguyen Viet Ha Thi , Nguyen Thanh Mai Thi , Bui Hien Van
Published: October 2023

Camellia quephongensis Hakoda et Ninh is a yellow-flowered camellia that inhabits the Que Phong District, Nghe An Province, North-Central Vietnam, and its taxon includes approximately 50 species from South China and Vietnam. Researchers have primarily focused on the taxonomy and biochemistry of medicinal substances found in camellia flowers and on horticultural studies of their propagation. Consequently, habitat characteristics and adaptation mechanisms still need to be better understood. Thus, this study investigated the habitats of C. quephongensis in terms of landscape and stand composition, analyzed the morphological variabilities and age distribution patterns among different habitat types, and explored its adaptation mechanisms. The results revealed that this species preferentially inhabited forests on vulnerable slopes and stream banks, which were frequently disturbed by slope failure or flooding, while its multi-stemming traits were key factors in recovering from damage and persisting in such habitats. Relatively stable sites with fewer disturbances can be a source habitat, whereas frequently disturbed sites can be a sink habitat for the populations. Regular thinning of the shrub and herb layers in the plantation maintained a stand composition similar to that of natural stands; thus, succession control is recommended to conserve the naturally growing site of this species. The findings of this study will aid in the future conservation and restoration of growing areas.
Two Distinct Genotypes of Spissistilus festinus (Say, 1830) Reproduce and Differentially Transmit Grapevine Red Blotch Virus
Authors: Flasco Madison T. , Fuchs Marc F.
Published: October 2023

Two phenotypically similar but genetically distinct genotypes of Spissistilus festinus (Say, 1830) (Hemiptera: Membracidae), a pest of legume crops in Southern United States and a vector of grapevine red blotch virus (GRBV) in California vineyards, exist. No information is available on whether the two S. festinus genotypes, i.e., California (CA) and Southeastern (SE), are sexually compatible or whether the SE genotype can transmit GRBV. In this study, we established mixed mating S. festinus pairs for which the F1 offspring varied phenotypically compared with the offspring of same genotype pairs but acquired GRBV isolate NY175 at similar rates (p = 0.96) and with a similar viral genome copy number (p = 0.34). Likewise, rates of GRBV acquisition were alike for the two parental CA (58%, 61/105) and SE (61%, 65/106) genotypes (p = 0.74), though the GRBV copy number in the salivary glands was overall significantly higher for SE than CA individuals (p = 0.02). Furthermore, the GRBV transmission rate was significantly higher for the SE genotype (89%, 16/18) than the CA genotype (50%, 8/16) (p = 0.04). These results revealed the existence of two sexually compatible S. festinus genotypes with distinct GRBV transmission abilities, suggesting the need to study GRBV ecology in Southeastern United States and areas where the two genotypes might co-exist.
High-Flow Oxygen Therapy in the Perioperative Setting and Procedural Sedation: A Review of Current Evidence
Authors: Al-Husinat Lou’i , Jouryyeh Basil , Rawashdeh Ahlam , Alenaizat Abdelrahman , Abushehab Mohammad , Amir Mohammad Wasfi , Al Modanat Zaid , Battaglini Denise , Cinnella Gilda
Published: October 2023

High-flow oxygen therapy (HFOT) is a respiratory support system, through which high flows of humidified and heated gas are delivered to hypoxemic patients. Several mechanisms explain how HFOT improves arterial blood gases and enhances patients’ comfort. Some mechanisms are well understood, but others are still unclear and under investigation. HFOT is an interesting oxygen-delivery modality in perioperative medicine that has many clinical applications in the intensive care unit (ICU) and the operating room (OR). The purpose of this article was to review the literature for a comprehensive understanding of HFOT in the perioperative period, as well as its uses in procedural sedation. This review will focus on the HFOT definition, its physiological benefits, and their mechanisms, its clinical uses in anesthesia, and when it is contraindicated.
Janus Kinase Inhibitors in Rheumatoid Arthritis: An Update on the Efficacy and Safety of Tofacitinib, Baricitinib and Upadacitinib
Authors: Harrington Robert , Harkins Patricia , Conway Richard
Published: October 2023

Janus kinase inhibitors (JAKis) are the most recent new drug class to arrive to the market for rheumatoid arthritis (RA) treatment. While they have proven to be a very effective treatment option, there remains significant concern regarding the risk of cardiovascular events, thrombosis and malignancy, particularly given the findings of the post-marketing ORAL Surveillance study and FDA black box warnings. This article reviews the key findings of the most impactful cohort of studies and registry data since ORAL Surveillance. It also evaluates the role of JAKis in practice and offers guidance on risk stratifying patients and determining their suitability for a JAKi.
Due Diligence of a Diastolic Index as a Prognostic Factor in Heart Failure with Preserved Ejection Fraction
Authors: Hoshida Shiro
Published: October 2023

Of the existing non-invasive diastolic indices, none consider arterial load. This article reveals points of caution for determining the diastolic prognostic index using a novel index of vascular resistance-integrated diastolic function in old, real-world patients with heart failure with preserved ejection fraction (HFpEF) in Japan. This index represents the ratio of left ventricular diastolic elastance (Ed) to arterial elastance (Ea), where Ed/Ea = (E/e′)/(0.9 × systolic blood pressure), showing a relative ratio of left atrial filling pressure to left ventricular end-systolic pressure. The role of hemodynamic prognostic factors related to diastolic function, such as Ed/Ea, may differ according to the clinical endpoint, follow-up duration, and sex. In HFpEF patients with heterogenous cardiac structure and function, an assessment using a serial echocardiographic diastolic index in clinical care can provide an accurate prognosis.
Chiari Syndrome: Advances in Epidemiology and Pathogenesis: A Systematic Review
Authors: Rodríguez-Blanque Raquel , Almazán-Soto Cristina , Piqueras-Sola Beatriz , Sánchez-García Juan Carlos , Reinoso-Cobo Andrés , Menor-Rodríguez María José , Cortés-Martín Jonathan
Published: October 2023

Arnold Chiari syndrome is a rare congenital disease of unknown prevalence and whose origin is still under study. It is encompassed within the posterior cranial malformations, showing a wide spectrum of symptomatology that can range from severe headache, dizziness, and paresthesia to complete asymptomatology. It is for this reason that early diagnosis of the disease is difficult, and it is usually diagnosed in adolescence. Treatment is based on remodeling and decompression of the malformed posterior cranial fossa, although the risk of residual symptoms after surgery is high. The aim of this review is to update all the existing information on this pathology by means of an exhaustive analysis covering all the scientific literature produced in the last 5 years. In addition, it has been carried out following the PRISMA model and registered in PROSPERO with code CRD42023394490. One of the main conclusions based on the results obtained in this review is that the origin of the syndrome could have a genetic basis and that the treatment of choice is the decompression of the posterior cerebral fossa.
Efficacy of Switching to Adalimumab for Maintenance of Remission Following Induction Therapy with Tacrolimus in Patients with Ulcerative Colitis
Authors: Numa Keijiro , Kakimoto Kazuki , Tanaka Yasuyoshi , Mizuta Noboru , Kinoshita Naohiko , Nakazawa Kei , Koshiba Ryoji , Hirata Yuki , Ota Kazuhiro , Miyazaki Takako , Nakamura Shiro , Higuchi Kazuhide , Nishikawa Hiroki
Published: October 2023

Background: Tacrolimus (TAC) effectively induces remission in refractory ulcerative colitis (UC). However, TAC therapy usually lasts for 3 months. Although azathioprine (AZA) is often used in maintenance therapy, the relapse rate remains high. Herein, we evaluated the efficacy of adalimumab (ADA) for remission maintenance in patients with UC after induction therapy with TAC. Methods: We prospectively enrolled patients with moderate-to-severe UC who achieved clinical remission after 3 months of TAC therapy with endoscopic non-mucosal healing (Cohort A). After TAC discontinuation, the remission maintenance rate up to 1 year after starting ADA therapy was examined. We retrospectively enrolled patients with UC treated with TAC (Cohort B). Among patients in clinical remission after TAC treatment for 3 months, those who received AZA as remission maintenance therapy after TAC discontinuation constituted the AZA group. Patients in Cohort A who received ADA and AZA as remission maintenance therapy after TAC discontinuation constituted the ADA + AZA group. We compared the remission maintenance rates in the AZA and ADA + AZA groups for up to 5 years after TAC discontinuation. Results: In Cohort A, of the 46 patients with UC treated with TAC, 17 were eligible for analysis after receiving ADA as remission maintenance therapy. A notable 88.2% (15/17) were still in remission 1 year after starting ADA. The ADA + AZA group (n = 16) exhibited a significantly higher relapse-free rate than the AZA group (n = 26) (p < 0.05; log-rank test). Conclusion: switching to ADA for remission maintenance in patients with refractory UC who achieved clinical remission with TAC is clinically useful.
A Simplified Convex Optimization Model for Image Restoration with Multiplicative Noise
Authors: Che Haoxiang , Tang Yuchao
Published: October 2023

In this paper, we propose a novel convex variational model for image restoration with multiplicative noise. To preserve the edges in the restored image, our model incorporates a total variation regularizer. Additionally, we impose an equality constraint on the data fidelity term, which simplifies the model selection process and promotes sparsity in the solution. We adopt the alternating direction method of multipliers (ADMM) method to solve the model efficiently. To validate the effectiveness of our model, we conduct numerical experiments on both real and synthetic noise images, and compare its performance with existing methods. The experimental results demonstrate the superiority of our model in terms of PSNR and visual quality.
Analysis of the Factors Intervening in the Prehospital Time in a Stroke Code
Authors: Astasio-Picado Álvaro , Chueca Yolanda Cruz , López-Sánchez Miriam , Lozano Rocio Ruiz , González-Chapado María Teresa , Ortega-Trancón Vanesa
Published: October 2023

Introduction: Strokes continue to be considered public health problems due to the great social and health impact they entail. They are the second cause of death in the world, with a high incidence and prevalence. They are time-dependent diseases, and more than 80% of cases could be avoidable with greater management of risk factors. Objective: to analyze the factors that influence prehospital time in a stroke code. Assess the population’s knowledge of stroke symptoms and teach them how to act when a case is suspected. Document the continued training of health professionals for the early identification of patients with a suspected stroke. Demonstrate the importance of calling EMS as the first contact to reduce delays in prehospital time in a stroke. Methodology: A bibliographic review was carried out focusing on articles published between December 2014 and August 2023. The following databases were consulted: Pubmed (Medline), Dialnet, Google Scholar, Web of Science (WOS), Scielo, Scopus, and ScienceDirect. Results: After applying the article selection criteria and evaluating the quality of the methodology, a total of 18 articles were obtained. The results affirm that the importance of achieving a reduction in prehospital time is based mainly on knowledge of the symptoms and the use of new technologies. Conclusions: The evidence supports that the prehospital time of action in the stroke code is affected by numerous factors. These factors are determining factors in the time of action to achieve good effectiveness in the treatment of the pathology.
Employment of Land-Expropriated Farmers: The Effects of Land Expropriation and Gender Difference
Authors: Wang Yue , Liao Dengjiao , Yan Bin , Lu Xinhai
Published: October 2023

The employment inequality between males and females in the context of land expropriation is not conducive for land-expropriated farmers to earn a sustainable livelihood. In this study, based on the data of two waves of household surveys, the “Chinese Family Panel Study” in 2016 and 2018, the PSM-DID method is used to test the effects of land expropriation on the employment behavior of the rural labor force, and the heterogeneous results of men’s and women’s employment behaviors are analyzed. The following conclusions are drawn. Land expropriation significantly reduces the employment probability of the labor force, encouraging the rural labor force to withdraw from the labor market voluntarily; land expropriation significantly shortens the employment distance of the labor force overall, promoting the urbanization of the rural labor force in the vicinity; land expropriation has a greater impact on the unemployment of the female labor force than that of the male labor force, and it increases the employment distance of males and reduces that of females, promoting the return of females’ labor to the family. The policy significance of this study is to attach importance to the long-term sustainable livelihoods of rural households and the employment equality of males and females in urbanization. Findings suggest family–friendly compensation for land expropriation should be formulated, rural construction land should be allowed to enter the market instead of being expropriated, and cooperation between county and developed regions should be encouraged for the creation of more jobs.
Accepting Solar Photovoltaic Panels in Rural Landscapes: The Tangle among Nostalgia, Morality, and Economic Stakes
Authors: Li Shengyuan , Gou Zhonghua
Published: October 2023

In the context of climate change and rural revitalization, numerous solar photovoltaic (PV) panels are being installed on village roofs and lands, impacting the enjoyment of the new rural landscape characterized by PV panels. However, the visual acceptance of PV panels in rural areas of China is not yet fully understood. This study aims to identify and correlate three key influential factors that contribute to the acceptance and appreciation of PV panels in China’s rural settings. A quasi-experiment was conducted, incorporating diverse landscapes into six rural settings, each containing both the original landscape and PV panels. The findings demonstrated that the original rural landscape was significantly more scenic than PV panels, and factors contributing to the appreciation of traditional landscapes, such as nostalgia, played a vital role in rejecting PV panels. Conversely, renewable energy-related factors, such as economic stakes and moral desirability, were found to contribute to the acceptance of PV panels. This study contributes to the strategic planning and design of solar PV panels in rural landscapes, taking into consideration social acceptance and local contexts.
Identification of Destruction Processes and Assessment of Deformations in Compressed Concrete Modified with Polypropylene Fibers Exposed to Fire Temperatures Using Acoustic Emission Signal Analysis, Numerical Analysis, and Digital Image Correlation
Authors: Adamczak-Bugno Anna , Lipiec Sebastian , Adamczak Jakub , Vičan Josef , Bahleda František
Published: October 2023

This article presents the results of tests conducted to identify the failure process and evaluate the deformation of axially compressed concrete specimens modified with polypropylene fibers (PP). The test specimens were previously stored at ambient temperature and subjected to fire temperatures of 300 °C, 450 °C, and 600 °C. Acoustic emission (AE) signals were recorded during loading, along with force and strain measurements. The recorded AE signals were analyzed using the k-means clustering method. The compilation of the test results made it possible to determine the classes of signals characteristic of different stages of the material failure process and to indicate the differences in the failure mechanisms of specimens stored under ambient conditions and subjected to fire temperatures. Digital image correlation (DIC) measurements were conducted during the strength tests. A numerical model of the material (FEM) was also prepared, and a comparison of the obtained results was carried out.
Effect of Artificial Saliva Modification on Pitting Corrosion and Mechanical Properties of the Remanium®-Type Orthodontic Archwire
Authors: Łosiewicz Bożena , Osak Patrycja , Górka-Kulikowska Karolina , Goryczka Tomasz , Dworak Michał , Maszybrocka Joanna , Aniołek Krzysztof
Published: October 2023

The pitting corrosion of orthodontic apparatus elements in the oral environment is an interest of both clinicians and scientists dealing with the assessment of the biocompatibility of medical materials. This work presents a study on the effect of ready-to-use Listerine® and Meridol® mouthwashes and sodium fluoride on the resistance of the commercial Remanium®-type orthodontic archwire to pitting corrosion in artificial saliva at 37 °C. XRD, SEM, EDS, mechanical properties, and microhardness measurements were used to characterize the archwire. The in vitro corrosion resistance of the archwire was examined using the open-circuit potential method, electrochemical impedance spectroscopy, and anodic polarization curves. The physicochemical characteristics confirmed the presence of a bi-phase alloy with a mixed austenite/ferrite structure containing Fe 74.4(7) at.%, Cr 18.4(4) at.%, and Ni 7.2(4) at.%. The Fe–Cr–Ni alloy was characterized by high tensile strength and Vickers microhardness. EIS revealed the capacitive behavior with high corrosion resistance. It was found that the kinetics of pitting corrosion in the artificial saliva decreased in the presence of NaF and mouthwashes. The potentiodynamic characteristics confirmed the decrease in susceptibility to pitting corrosion after the modification of artificial saliva. The pitting corrosion mechanism of the self-passive oxide layer on the surface of the Fe–Cr–Ni electrode in the biological environment containing chloride ions was discussed in detail. Mechanical properties after corrosion tests were weakened.
Dual-Emissive Monoruthenium Complexes of N(CH3)-Bridged Ligand: Synthesis, Characterization, and Substituent Effect
Authors: Wu Si-Hai , Zhang Zhe , Zheng Ren-Hui , Yang Rong , Wang Lianhui , Shao Jiang-Yang , Gong Zhong-Liang , Zhong Yu-Wu
Published: October 2023

Three monoruthenium complexes 1(PF6)2–3(PF6)2 bearing an N(CH3)-bridged ligand have been synthesized and characterized. These complexes have a general formula of [Ru(bpy)2(L)](PF6)2, where L is a 2,5-di(N-methyl-N’-(pyrid-2-yl)amino)pyrazine (dapz) derivative with various substituents, and bpy is 2,2′-bipyridine. The photophysical and electrochemical properties of these compounds have been examined. The solid-state structure of complex 3(PF6)2 is studied by single-crystal X-ray analysis. These complexes show two well-separated emission bands centered at 451 and 646 nm (Δλmax = 195 nm) for 1(PF6)2, 465 and 627 nm (Δλmax = 162 nm) for 2(PF6)2, and 455 and 608 nm (Δλmax = 153 nm) for 3(PF6)2 in dilute acetonitrile solution, respectively. The emission maxima of the higher-energy emission bands of these complexes are similar, while the lower-energy emission bands are dependent on the electronic nature of substituents. These complexes display two consecutive redox couples owing to the stepwise oxidation of the N(CH3)-bridged ligand and ruthenium component. Moreover, these experimental observations are analyzed by computational investigation.
Effect of Mud Powder on the Performance of Bridge Deck Leveling Concrete in a Seasonally Frozen Region
Authors: Shi Chenglin , Zhao Ruize , Wang Wensheng
Published: October 2023

Mud powders in aggregates are often found to cause deterioration of concrete properties. Based on a study of the mechanical properties of bridge deck leveling concrete (BDLC) containing different mud powders at various ages, the effects of mud powders on concrete durability were evaluated through rapid chloride permeability testing, freeze–thaw testing, and the coupling of salt solution and a freeze–thaw test. The properties of the interfacial transition zone (ITZ) were also investigated via microhardness testing. The test results showed that mud powder reduced the compressive strength, static compressive elastic modulus, and bond strength at early stages of curing. Moreover, mud powder was found to reduce the tensile properties and durability of concrete, with clay powder causing a greater reduction than mud powder in river sands and coarse aggregate. In addition, the width of the ITZ of concrete containing mud powder was found to increase by 23.1–48.3%. A significant correlation between the ITZ and the tensile properties, as well as the durability of concrete, was also observed. Therefore, in order to improve the tensile properties and durability of BDLC in seasonally frozen regions, the content of mud powder in the aggregates should be minimized according to the different compositions of mud powders. The coupling effect of salt solution and a freeze–thaw cycle should also be taken into consideration.
Stress Distribution Prediction of Circular Hollow Section Tube in Flexible High-Neck Flange Joints Based on the Hybrid Machine Learning Model
Authors: Dai Kaoshan , Du Hang , Luo Yuxiao , Han Rui , Li Ji
Published: October 2023

The flexible high-neck flange is connected to the circular hollow section (CHS) tube through welding, and the placement of the weld seam and corresponding stress concentration factor (SCF) are crucial determinants of the joint’s fatigue performance. In this study, three hybrid models combining ant colony optimization (ACO), a genetic algorithm (GA), and grey wolf optimization (GWO) with a random forest (RF) model were developed to predict the stress distribution on the inner and outer walls of the CHS tube under different flange parameter combinations. To achieve this, an automated finite element (FE) analysis program for flexible high-neck flange joints was initially developed based on ABAQUS 2020 software. Parameter combinations were randomly selected within a reasonable range to simulate the nonlinear mechanical behavior of the joint under uniform tension, generating a dataset comprising 5417 sets of data. The accuracy of the FE model was validated through experimental data from the literature. Based on this, feature importance analysis was conducted to reveal the influence of different variable parameters on the stress distribution in the tube of the joint. The flange parameters and tube stress distribution are considered as inputs and outputs, respectively. Three hybrid RF models, specifically ant colony optimization-based random forest (ACO-RF), genetic algorithm-based random forest (GA-RF), and grey wolf optimization-based random forest (GWO-RF), are trained for regression prediction. The results demonstrate that the three hybrid models outperform the original machine learning model in predictive accuracy. The ACO-RF model achieved the highest accuracy with average coefficients of determination (Rmean2) of 0.9983 and 0.9865 on the testing and training sets, respectively. Building upon this foundation, the study developed a corresponding open-source graphical user interface (GUI) as a tool for facilitating computations and visualizing results. Finally, a case study on fatigue damage assessment of a flexible high-neck flange joint in a wind-turbine tower is presented to demonstrate the application of the proposed model in this study.
Cost-Effectiveness of Treatment Decisions for Early Childhood Caries in Infants and Toddlers: A Systematic Review
Authors: Wolf Thomas Gerhard , Campus Guglielmo
Published: October 2023

Background and Objectives: Early childhood caries (ECC) is a multifactorial, biofilm-mediated, sugar-related, dynamic disease of primary dental hard tissues occurring in varying degrees of severity in infants and toddlers. Untreated ECC may lead to pain, infections, and severe systemic complications. The aim of this study was to systematically review and evaluate the scientific evidence on the cost-effectiveness of treatment decisions in ECC in infants and toddlers. Materials and Methods: Observational epidemiological studies, i.e., cohort studies, case–control studies, and randomized controlled trials, reporting cost-effectiveness of treatment decisions in ECC in infants and toddlers were included in the systematic review following the PRISMA guidelines. Using an ad hoc search with search terms or keywords (MeSH), electronic databases Embase, MEDLINE via PubMed, Scopus, and gray literature were searched. Results: The search identified 494 articles, of which 446 remained after removing duplicates. A total of 417 articles were excluded after title and abstract evaluation; 29 full-text articles were screened for eligibility, and five articles were discarded. Twenty-four full-text articles were included in the systematic review, assigning 17 to prevention and seven to restoration. Results were heterogeneous; comparability of included studies is difficult because of the different methodologies used. Conflicting efficacies were demonstrated for different interventions implemented, and cost-effectiveness data were documented. Conclusions: Socioeconomic, cultural, and ethnic differences must be considered when comparing conditions in terms of cost-effectiveness. A paradigm shift from surgical towards preventive treatment decisions can be observed. Cost-effectiveness studies on therapies for ECC in infants and toddlers are needed to identify the best practice approach and the most cost-effective therapy decisions.
Assessment of Knowledge, Attitude, and Practice Patterns in Pulmonary Arterial Hypertension among Cardiologists and Pulmonologists: Evidence from Turkey
Authors: Günaydın Fatma Esra , Belen Erdal , Altın Sedat , Demir Ahmet Uğur , Güven Gülden , Durmuş Gündüz
Published: October 2023

Background and Objectives: Pulmonary arterial hypertension (PAH) is a rare chronic disease of the small pulmonary arteries that causes right heart failure and death. Accurate management of PAH is necessary to decrease morbidity and mortality. Understanding current practices and perspectives on PAH is important. For this purpose, we intended to determine physicians’ knowledge, attitudes, and practice patterns in adult pulmonary arterial hypertension (PAH) in Turkey. Materials and Methods: Between January and February 2022, an online questionnaire was sent via e-mail to all cardiologists and pulmonologists who were members of the Turkish Society of Cardiology (TSC) and the Turkish Thoracic Society (TTS). Results: A total of 200 physicians (122 pulmonologists and 78 cardiologists) responded to the questionnaire. Cardiologists were more frequently involved in the primary diagnosis and treatment of PAH than pulmonologists (37.2% vs. 23.8%, p = 0.042). More than half of the physicians had access to right heart catheterization. In mild/moderate PAH patients with a negative vasoreactivity test, the monotherapy option was most preferred (82.8%) and endothelin receptor antagonists (ERAs) were the most preferred group in these patients (73%). ERAs plus phosphodiesterase-5 inhibitors (PDE-5 INH) were the most preferred (69%) combination therapy, and prostacyclin analogues plus PDE-5 INH was preferred by only pulmonologists. Conclusions: Overall, clinical management of patients with PAH complied with guideline recommendations. Effective clinical management of PAH in specialized centers that having right heart catheterization achieve better outcomes.
A Mediterranean-Style Diet Improves the Parameters for the Management and Prevention of Type 2 Diabetes Mellitus
Authors: Derrick Stefani A. , Nguyen Sarah T. , Marthens Jordan R. , Dambacher Leah L. , Sikalidis Angelos K. , Reaves Scott K.
Published: October 2023

Background and Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition recognized as the inability to maintain glucose homeostasis, typically presenting with insulin resistance and systemic inflammation. With the prevalence of T2DM and major risk factors, such as prediabetes and obesity, increasing each year, the need to address risk factor reduction strategies is crucial. Materials and Methods: Twenty-two men and women, overweight-to-obese adults (BMI mean: 26.1–31.6) (age range mean: 44.6–51.8) with T2DM, indicators of prediabetes, or who were metabolically healthy, participated in Cal Poly’s Nutrition and Exercise in Type 2 Diabetes (CPNET) study. There were no significant differences in terms of age, BMI, or sex distribution among the groups at the baseline. This study’s protocol included following a Mediterranean-style diet, the daily consumption of a high-quality whey protein supplement, and physical activity recommendations for 16 weeks. Body composition data, via dual-energy X-ray absorptiometry (DXA), and fasting blood samples were collected at the baseline and following the intervention. Due to restrictions associated with the outbreak of the COVID-19 pandemic, only 13 of the 22 participants who started this study were able to return for the second data collection to complete this study following the 16-week intervention. Results: The prediabetic and T2DM groups exhibited reductions in their fasting plasma glucose (12.0 mg/dL reduction in the prediabetic group; 19.6 mg/dL reduction in the T2DM group) to that of normal and prediabetic levels, respectively, while the T2DM group also demonstrated improvement in their hemoglobin A1c (reduced from 6.8% to 6.0%) to prediabetic levels. Additionally, the metabolically healthy, overweight group exhibited significant improvements in adiposity, while the obese prediabetic and T2DM groups showed non-significant improvements in all the measured metrics of body composition. No significant changes were observed in the inflammatory biomarkers (p-values ranged from 0.395 to 0.877). Conclusions: Collectively, our results suggest that adherence to a well-balanced, nutritious diet and activity may improve the parameters of glycemic control and provide benefits to body composition that help to manage and prevent the development of T2DM. Our study was able to yield significant findings signifying that the effects of a Mediterranean-style diet are observed even for a more conservative sample size.
The Benefits of Combining Bobath and Vojta Therapies in Infants with Motor Development Impairment—A Pilot Study
Authors: Parau Daniela , Todoran Anamaria Butila , Barcutean Laura , Avram Calin , Balasa Rodica
Published: October 2023

Background: In infants presenting with motor development impairment, early kinesiotherapeutic interventions aim to normalise the pattern of movements and improve recovery. By applying Bobath and Vojta methods, we aimed to identify a combined approach regarding motor deficit in infants with neurological disabilities. Methods: We designed a prospective interventional study on 108 infants with motor developmental delay and applied Bobath, Vojta, or combined Bobath and Vojta therapy in three equal groups. Results: In the combined Bobath and Vojta group, complete motor recovery was achieved for 50% of the participants, with full recovery after six months, whereas in Bobath- or Vojta-only therapy groups, the total recovery for all participants was achieved at seven months. Regarding infants with muscular hypertonia, Bobath therapy initiation demonstrated complete recovery in 5 months in more than 50% of the cases, while for Vojta this was achieved in only 33.57% of the cases. Conclusions: The comparative evaluation conducted by analysing the data regarding the application of the Bobath and Vojta methods showed that combining these two therapies results in a shorter motor deficit recovery time than if a single therapy is applied. These findings have important implications for the selection of rehabilitation therapies in infants with neurological motor development issues.
Two Cases of Congenital Hypothyroidism Revealing Thyroid Agenesis
Authors: Năstase Leonard , Cristea Octaviana , Diaconu Alexandra , Stoicescu Silvia-Maria , Mohora Ramona , Pascu Bogdan Mihai , Tala Simona Tania , Roșca Ioana
Published: October 2023

Congenital hypothyroidism (CH) may have major detrimental effects on growth and neurological development, but early intervention leads to excellent outcomes. CH is classified as transient or permanent, primary or secondary, with primary CH being the most common neonatal endocrine disorder. Most patients with CH do not present any typical signs and symptoms of hypothyroidism shortly after birth, partly due to transplacental maternal thyroid hormone transfer and residual neonatal thyroid function. This paper reports on two CH cases. During the initial Neonatal Intensive Care Unit (NICU) admission phase, CH was not suspected due to nonspecific signs. The distinct characteristics of our cases are as follows: both infants were admitted to the NICU for respiratory distress syndrome, requiring invasive mechanical ventilation, and both were born to diabetic mothers. Following extubation, they both showed similar neurological issues, including reduced muscle tone and feeding difficulties. Initially, those symptoms were attributed to delayed clearance of analgesic and sedative medication. However, symptoms progressively worsened over time. Subsequent tests revealed both meeting CH diagnostic criteria: an unusual ultrasound indicating thyroid agenesis and abnormal hormone levels. Guided by the pediatric endocrinology team, prompt hormonal treatment was started with improvements in neurocognitive function and feeding. Usually, CH screening involves blood samples from healthy newborns at 2–3 days of life. Abnormal results require confirmation, prompting treatment within two weeks. Certain NICU-admitted infants face higher diagnosis delays, as seen in those two cases where CH screening was postponed. Thus, for all neonates with persistent pathologies unresponsive to standard etiological treatment, conducting a comprehensive anamnestic evaluation of the medical history, along with maternal preconceptional and prenatal nutrition, is recommended.
Effects of Finish Rolling Temperature on the Critical Crack Tip Opening Displacement (CTOD) of Typical 500 MPa Grade Weathering Steel
Authors: Wu Junping , Bai Guangming , Zhao Liyang , Zhang Zhongde , Peng Yan , Chu Juefei , Wang Qingfeng
Published: October 2023

In this study, the effect of finish rolling temperature on the critical crack tip opening displacement (CTOD) of typical 500 MPa grade weathering steel was elucidated. The microstructures were observed via optical microscope (OM), scanning electron microscope (SEM), transmission electron microscope (TEM), and electron back-scattered diffraction (EBSD). The cryogenic fracture toughness and microstructures of steels were analyzed at different finish rolling temperatures (780–840 °C). The results show that a mixed microstructure, i.e., granular bainitic ferrite (GBF), polygonal ferrite (PF), and martensite/austenite (M/A), constituent was formed in each sample. With the decrease of the finish rolling temperature, the GBF content decreased, PF content increased, and the high angle grain boundary (HAGB) number fraction of the matrix increased. Furthermore, the fraction of M/A constituents was increased with reduced average size. The value of CTOD increased significantly from 0.28 to 1.12 mm as the finish rolling temperature decreased from 840 to 780 °C. Both the decrease of M/A constituents and the increase of HAGB increased the cryogenic (−40 °C) fracture toughness of the typical 500 MPa grade weathering steel.
An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of Helichrysum splendidum and Its Pharmaceutical Potentials
Authors: Lephatsi Motseoa Mariam , Choene Mpho Susan , Kappo Abidemi Paul , Madala Ntakadzeni Edwin , Tugizimana Fidele
Published: October 2023

South Africa is rich in diverse medicinal plants, and it is reported to have over 35% of the global Helichrysum species, many of which are utilized in traditional medicine. Various phytochemical studies have offered valuable insights into the chemistry of Helichrysum plants, hinting at bioactive components that define the medicinal properties of the plant. However, there are still knowledge gaps regarding the size and diversity of the Helichrysum chemical space. As such, continuous efforts are needed to comprehensively characterize the phytochemistry of Helichrysum, which will subsequently contribute to the discovery and exploration of Helichrysum-derived natural products for drug discovery. Thus, reported herein is a computational metabolomics work to comprehensively characterize the metabolic landscape of the medicinal herb Helichrysum splendidum, which is less studied. Metabolites were methanol-extracted and analyzed on a liquid chromatography–tandem mass spectrometry (LC-MS/MS) system. Spectral data were mined using molecular networking (MN) strategies. The results revealed that the metabolic map of H. splendidum is chemically diverse, with chemical superclasses that include organic polymers, benzenoids, lipid and lipid-like molecules, alkaloids, and derivatives, phenylpropanoids and polyketides. These results point to a vastly rich chemistry with potential bioactivities, and the latter was demonstrated through computationally assessing the binding of selected metabolites with CDK-2 and CCNB1 anti-cancer targets. Molecular docking results showed that flavonoids (luteolin, dihydroquercetin, and isorhamnetin) and terpenoids (tiliroside and silybin) interact strongly with the CDK-2 and CCNB1 targets. Thus, this work suggests that these flavonoid and terpenoid compounds from H. splendidum are potentially anti-cancer agents through their ability to interact with these proteins involved in cancer pathways and progression. As such, these actionable insights are a necessary step for further exploration and translational studies for H. splendidum-derived compounds for drug discovery.