bluuebunny/crossref_metadata_2025 huggingface dataset:
PELATIHAN SIKLUS PENJUALAN MENGGUNAKAN SOFTWARE ACCURATE BAGI SISWA/I SMA TARSISIUS 1
Authors: Verawati Verawati , Valencia Valencia , Felia Susanto Marcella
Published: November 2023

Digitalisasi semakin berkembang dalam setiap aspek, terutama dalam aspek usaha. Hal ini didukung oleh adanya perkembangan teknologi dan internet. Ketika suatu usaha sudah terdigitalisasi, maka kegiatan akuntansi pun akan ikut menyesuaikan. Kegiatan akuntansi akan ikut terdigitalisasi karena fungsi akuntansi merupakan suatu infrastrukur yang mendukung kegiatan usaha, dimana setiap kegiatan usaha perlu mencatat dan menghasilkan laporan keuangannya. Siklus penjualan merupakan suatu siklus dimana suatu usaha mendapatkan pelanggan dan memperoleh pendapatan. Penggunaan software dapat membantu kegiatan dalam siklus penjualan sehingga menjadi lebih efisien dan hemat biaya. Namun, salah satu kendala yang dihadapi dalam kegiatan penjualan yang sudah terdigitalisasi adalah kemampuan dari sumber daya manusia yang dimilikinya untuk mengoperasikan perangkat dan teknologi yang ada. Pelatihan siklus penjualan menggunakan software Accurate ini dilakukan dengan tujuan supaya para siswa SMA Tarsisius 1 yang mengambil ekstrakurikuler akuntansi dapat mengetahui langkah-langkah dan cara mengoperasikan software Accurate untuk mendukung kegiatan dalam siklus penjualan. Pelatihan dilaksanakan pada tanggal 08 Februari 2023 secara tatap muka di ruang komputer SMA Tarsisius 1. Materi yang disampaikan antara lain mencakup teori mengenai transaksi dalam siklus penjualan dan latihan soal transaksi penjualan yang dipraktekkan langsung penginputannya ke dalam software Accurate. Luaran dari kegiatan PKM ini adalah artikel dalam prosiding.
PELATIHAN PENYUSUNAN LAPORAN KEUANGAN PADA TOKO SEMBAKO DEWI DI BEKASI
Authors: Ruslim Herman , Rizka Yukianti Chaira , Laurent Margaret
Published: November 2023

Laporan keuangan merupakan suatu informasi yang menjelaskan kondisi keuangan badan usaha yang digunakan sebagai bayangan performance keuangan lembaga usaha. Untuk itu, laporan keuangan dapat dinyatakan sebagai alat yang sangat penting dalam upaya mencapai tujuan dalam memperoleh informasi, baik yang menyangkut kondisi keuangan suatu usaha, sampai pada hasil kinerja yang akan dicapai oleh perusahaan tersebut. Melalui laporan keuangan ini, dapat diketahui kinerja keuangan suatu usaha, sehingga dapat digunakan sebagai dasar evaluasi dalam langkah keputusan selanjutnya. Program PKM ini berupa pelatihan pembuatan laporan laba rugi pada toko sembako ini di Bekasi. Tujuan dari kegiatan ini adalah memberikan input kepada usaha ini untuk memulai melakukan pencatatan terhadap aktivitasnya. Melalui pencatatan yang tepat maka pada akhirnya dapat merapikan keuangan toko ini. Universitas Tarumanagara turut membantu dalam hal penyediaan dana dalam terciptanyanya kegiatan ini.
PENGENALAN YOUTH AND SUSTAINABLE DEVELOPMENT GOALS (SDGs) BAGI SISWA/I SMA KRISTEN YUSUF
Authors: Henny Wirianata  , Catherine Carissa Tanaya  , Felicia Ivana
Published: November 2023

Youth atau pemuda sangat berkaitan dengan Sustainability Development Goals (SDGs) / Tujuan Pembangunan Berkelanjutan (TPB), karena pemuda merupakan salah satu prioritas penting dalam pencapaian SDGs. Generasi pemuda masa kini merupakan calon pemimpin dan pengambil keputusan di masa depan. Melihat pada pentingnya keberadaan pemuda dalam masyarakat Indonesia dan dunia, maka perlu dilakukan sosialisasi dan pengenalan tentang SDGs agar para pemuda dapat bertindak dan berperan serta dalam mendukung pencapaian SDGs. Tim PKM Untar berkesempatan untuk melakukan pelatihan dalam bentuk sosialisasi dan pengenalan tentang SDGs kepada siswa/i SMA Kristen Yusuf. Pelatihan dilakukan pada hari Senin, 3 April 2023 pukul 13.15 – 14.00. Pelatihan dilakukan secara luring (tatap muka) di sekolah SMA Kristen Yusuf. Selama kegiatan pelatihan berlangsung, peserta pelatihan menunjukkan antusias dan ketertarikan tentang SDGs. Berdasarkan hasil evaluasi di akhir pelatihan, dapat disimpulkan bahwa siswa-siswi SMA Kristen Yusuf dapat menerima dengan baik penjelasan tentang Youth and Sustainable Development Goals (SDGs). Hasil evaluasi juga menunjukkan bahwa pelatihan ini bermanfaat bagi para peserta pelatihan. Para peserta cenderung memilih untuk menjadi Critical thinkers dan Change-makers dalam upaya mendukung SDGs. Hasil kuesioner juga menunjukkan ide-ide para peserta dalam melakukan tindakan nyata untuk mendukung pencapaian SDGs.
PSIKOEDUKASI PENGENALAN DIRI DI SD NEGERI 03 SIJUK KABUPATEN BELITUNG
Authors: Cut Salma Komala Thayeb  , Riska Andini Hasnabila  , Nur Laeli Fentilia  , Reynaldi Salim  , Michael Housen  , Denrich Suryadi
Published: November 2023

Pendidikan seks masih menjadi hal yang tabu dalam masyarakat terlebih jika dibicarakan kepada anak usia dini, padahal pendidikan seks ini sangat penting mengingat anak akan memasuki usia remaja. Tingkat kekerasan seksual di Indonesia juga menjadi salah satu alasan mengapa pendidikan seks ini perlu diberikan kepada anak usia muda, karena tahun demi tahun kekerasan seksual ini mengalami peningkatan. Tujuan Pengabdian Kepada Masyarakat (PKM) ini adalah untuk membantu anak mengetahui topik biologis seperti pertumbuhan dan masa puber selain itu juga mencegah anak-anak dari tindak kekerasan dan mengurangi rasa malu ketika sedang mengalami masa pubertas. Kegiatan PKM dilaksanakan pada tanggal 3 April 2023 bertempat di Sekolah Dasar Negeri 03 Sijuk, Kabupaten Belitung dan dihadiri oleh 46 siswa-siswi SD tersebut. Metode yang digunakan dalam kegiatan pengabdian masyarakat ini berupa penyuluhan mengenai pengenalan diri dan pendidikan seks pada siswa. Sesi penyuluhan dibagi menjadi 2 sesi yaitu sesi pertama untuk penyampaian pendidikan seks kepada siswa laki-laki dan dilanjutkan dengan sesi 2 penyampaian pendidikan seks kepada siswa perempuan. Adapun materi yang disampaikan yaitu mengenai alasan individu harus mengenal diri, pengenalan anggota tubuh dan organ reproduktif, fase pubertas, perubahan psikis, gender role, dan masih banyak materi lain yang berhubungan dengan pendidikan seks secara umum. Kegiatan psikoedukasi ini membantu siswa-siswi untuk memiliki pengetahuan yang baik mengenai pendidikan seks dan belajar berani bertanya kepada orangtuanya saat membahas mengenai masalah seksualitas. Pihak sekolah juga sebaiknya melakukan kegiatan edukasi bagi para orangtua untuk mempersiapkan diri dengan ragam informasi mengenai seksualitas dan kesediaan untuk mendamping anak.
UPAYA PENGEMBANGAN PENGELOLAAN PERPUSTAKAAN SDN 1 SIJUK
Authors: Audreya Christine  , Tejaputra  , Griselda  , Steven Liauw  , Riyadh Akbar  , Fransisca Iriani R. Dewi
Published: November 2023

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk mengembangkan perpustakaan pada SDN 1 Sijuk. Perpustakaan penting dimiliki setiap sekolah karena murid dapat mengumpulkan informasi dan ilmu dari berbagai buku yang ada.Kenyataan yang ditemukan tim, perpustakaan di SDN 1 Sijuk tidak berjalan sebagimana yang seharusnya. Kurangnya sumber daya manusia di SDN 1 Sijuk menjadi salah satu alasana kondisi perpustakaan kurang atau tidak terurus dengan baik. Kurangnya SDM  atau tepatnya pegawai di SDN 1 Sijuk, dapat dicarkan solusi dengan memanfaatkan potensi SDM yang ada yaitu para murid. Tujuan dari kegiatan pengabdian masyarakat di SDN 01 Sijuk ini adalah untuk membantu sekolah SDN 01 Sijuk membuka kembali perpustakaan yang sudah tidak beroperasi karena kurangnya sumber daya manusia sebagai petugas perpustakaan melalui program pengembangan pengelolaan perpustakaan. Adanya pembentukan petugas perpustakaan yang diberi nama Superlib yang beranggotakan siswa SDN 01 Sijuk dari kelas 4 dan kelas 5 yang dipilih secara langsung oleh guru. Sasaran dari kegiatan PKM adalah para siswa yang akan diajarkan menjadi seorang petugas perpustakaan. Metode pelaksanaan dengan pendampingan untuk membentuk tim petugas perpustakaan. Tiga ( 3) tahapan yang dilakukan  yaitu:  (1)  persiapan dengan mengumpulkan data menggunakan teknik observasi, wawancara dan dokumentas,(2)  pelaksanaan dan evaluasi.Hasilnya pembentukan petugas perpustakaan dalam kelompok Superlib sebagai pelaksana petugas perpustakaan harian dapat berjalan dengan baik, melalui proses penyampaian materi oleh mahasiswa mengenai pengelola perpustakaan dan simulasi petugas perpustakaan. Hasil menunjukkan bahwa ada pengaruh terhadap layanan perpustakaan yang lebih efektif karena perpustakaan sekarang dapat berjalan kembali seperti semula dengan adanya sistem piket harian yang dilakukan oleh siswa SD.
PENGENALAN SISTEM PEMBAYARAN NON-TUNAI PADA SISWA SMA
Authors: Imelda Martinelli  , Samantha Elizabeth Fitzgerald  , Chakradevi Prawira
Published: November 2023

Perkembangan teknologi yang memudahkan dilakukannya transaksi antara para pihak tanpa keperluan untuk saling bertemu secara fisik. Hal ini didukung dengan perkembangan teknologi yang didampingi perlindungan yang diberikan oleh hukum yang mengatur mengenai transaksi. Secara konsep, transaksi jual-beli elektronik dan transaksi jual-beli konvensional memiliki persyaratan yang sama yaitu dilakukan antara paling sedikit terdapat dua pihak, seperti yang diamanatkan dalam Pasal 1313 KUH Perdata, Pasal 1320 KUH Perdata, dan Pasal  1473 KUH Perdata. Pada nyatanya banyak dikalangan siswa SMA yang melakukan transaksi dengan pembayaran menggunakan dompet digital dan membuat kesepakatan hukum ini diacuhkan demi terjualnya produk yang dijual. Para penyelenggara sistem elektronik (dompet digital atau platform pasar digital) tidak terlalu mempedulikan persyaratan hukum yang dimintakan atau diamanatkan oleh undang-undang.Permasalahan timbul pada saat transaksi jual-beli yang dilakukan secara elektronik terjadi, terutama transaksi yang dilakukan oleh para siswa SMP. Terdapatnya persyaratan yang tidak terpenuhi oleh para pembeli yang didasarkan persyaratan yang ditentukan oleh undang-undang mengenai kecakapan hukum. Menggunakan sistem pembayaran non-tunai, yaitu cicilan, paylater, atau kartu kredit menimbulkan suatu perikatan antara siswa dengan lembaga/pihak yang meminjamkan uang di mana remaja tersebut memiliki kewajiban untuk melunaskan seluruh uang yang jumlahnya setara dengan harga dari barang yang ia beli. Akan lebih merugikan lagi ketika ia telat bayar dan dikenakan denda atau beban biaya tambahan. Oleh karena itu, seorang siswa kurang mendapatkan pengedukasian terkait pemakaian alat-alat pembayaran tersebut maka dapat menimbulkan masalah dalam ranah hukum di kemudian hari.
LATAR BELAKANG DAN PERKEMBANGAN TINDAK PIDANA KORUPSI DI INDONESIA (MAKNA DAN SEJARAH BERKEMBANGNYA KEJAHATAN KORUPSI DAN BERDIRINYA KOMISI PEMBERANTASAN KORUPSI)
Authors: Ade Adhari  , Sherryl Naomi
Published: November 2023

Korupsi di Indonesia sudah menjadi budaya sejak era Orde Lama, Orde Baru hingga pada era Reformasi. Sudah dilakukannya berbagai upaya dalam memberantas korupsi, namun budaya ini tetap terjadi yang didorong oleh motif kekuasaan dan kekayaan. Pada era reformasi akhirnya lahirlah lembaga independen yaitu komisi pemberantasan korupsi (KPK) yang berfungsi dalam memberantas korupsi. Dalam Focus Group Discussion yang diselenggarakan oleh LPKAN Indonesia dan LKHAI, Pelaksana Pengabdian Kegiatan Masyarakat (PKM) berkesempatan untuk menjadi pembicara secara luring dalam diskusi terkait Analisis dan Evaluasi Pencegahan Kejahatan Korupsi di Indonesia. Fokus diskusi ini salah satunya membahas mengenai latar belakang, makna dan sejarah berkembangnya tindak pidana korupsi di Indonesia, lahirnya norma-norma terkait pemberantasan tindak pidana korupsi di Indonesia dan bagaimana akhirnya komisi pemberantasan korupsi dapat hadir di era reformasi sebagai lembaga independen yang bebas dari pengaruh kekuasaan manapun untuk memberantas korupsi secara professional, intensif dan berkesinambungan secara efektif dan efisien. Hasil dari kegiatan ini hendak menunjukkan bagaimana korupsi telah mewabah di Indonesia dan sudah seharusnya untuk diberantas bersama.
PEMBERIAN PEMAHAMAN URGENSI PERUBAHAN UU ITE BAGI KEMINFO
Authors: Ade Adhari  , Sherryl Naomi
Published: November 2023

Perkembangan globalisasi secara intensif telah terjadi dengan berkembangnya teknologi informasi dan komunikasi yang menyebabkan banyak perubahan kegiatan masyarakat dalam berbagai bidang. Seiring dengan perkembangan teknologi yang semakin kompleks, maka hukum harus bersifat dinamis untuk dapat mengikuti perkembangan masyarakat. Perubahan dalam suatu hukum bertujuan untuk mencapai keadilan di dalam masyarakatnya. Pemerintah perlu mendukung perkembangan teknologi informasi melalui infrastruktur hukum dan pengaturannya untuk tujuan pencegahan penyalahgunaan dengan memperhatikan nilai agama dan sosial budaya masyarakat Indonesia. Dalam kegiatan ini, Pelaksana Pengabdian Kegiatan Masyarakat (PKM) berkesempatan untuk menjadi pembicara secara daring dan luring dalam diskusi Pembaruan UU ITE dalam Perspektif Kebijakan Kriminal (Criminal Policy) dan Komentar terhadap DIM. Hasil kegiatan ini hendak memberikan pemahaman terhadap urgensi perubahan UU ITE bagi Kementerian Komunikasi dan Informasi.
The Role of the Fashion Industry and Textiles in Lung Health and Associated Pathogens: A Review
Authors: Yadav Ekta
Published: November 2023

The fashion industry is a significant contributor to global pollution, which can adversely impact lung health. This review examines the impact of the fashion industry and textiles on lung health and the pathogens involved, as reported in recent studies published within the last five years. We discuss the various sources of air pollutants, toxic fibers, and allergens in the fashion industry and textiles that can contribute to lung diseases and infections. Furthermore, we highlight the importance of taking appropriate preventative measures to minimize these risks and ensure better lung health
Impact of Sarcoidosis on Outcomes of Hospitalized COVID-19 Patients: A Nationwide Retrospective Cohort Study
Authors: Ibrahim Garad , Zaigham Afsah
Published: November 2023

The COVID-19 pandemic has been a global health crisis that has resulted in significant morbidity and mortality worldwide. Sarcoidosis, a chronic inflammatory disease, may potentially affect the course and outcomes of COVID-19 patients. This study aims to evaluate the impact of sarcoidosis on the outcomes of hospitalized COVID-19 patients.
The Five Wits in English Medical Literature, 1375-1600
Authors:   University of Helsinki (Finland), Taavitsainen Irma , Honkapohja Alpo ,   University of Oslo (Norway)
Published: November 2023

The five wits were an important component of culture in the Middle Ages, and passages dealing with the bodily wits occur frequently in early vernacular medical literature (1375- 1600). Our aim is to relate these texts to their readers to detect how the commonplace was presented to various audiences. We shall apply two lines of research. First, we shall discuss the linguistic realizations with qualitative discourse analysis. The data come from two digital corpora, Middle English Medical Texts (Taavitsainen, Pahta and Mäkinen 2005) and Early Modern English Medical Texts (Taavitsainen et al. 2010), compiled from edited versions. The scope of these passages is wide, ranging from theoretical treatises of natural philosophy and surgery to compendia and practical adaptations in recipes and remedybooks. Second, we provide case studies on the underlying manuscript reality by philological methods and study the same or related passages in some Cambridge and British Library manuscripts. The analysis showcases the importance of going back to the versions that reached the medieval audiences for the dissemination of medical knowledge in the early periods.
PRODUCTION OF RECOMBINANT RBD GLYCOPROTEIN SPIKE OF THE SARS-COV-2 VIRUS IN MAMMALIAN AND METHYLOTROPHIC YEAST CELLS
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Snegireva A.A. , Prudnikova E.Yu. , Ivkina D.I. , Imatdinov I.R.
Published: November 2023

This work is devoted to obtaining a homogeneous recombinant receptor-binding domain of the Spike glycoprotein of two variants of the SARS-CoV-2 virus (Delta B.1.617.2, Omicron B.1.1.529) for the study of antigen — antibody complexes with immunoglobulins of COVID-19 reconvalescents.
NORMALIZATION OF DEVIATED BIOCHEMICAL BLOOD PARAMETERS DURING LABORATORY TESTING OF AN EXPERIMENTAL PLASMA FILTER
Authors:   Ammosov North-Eastern Federal University, Yakutsk, Troev I.P. , Sleptsov A.A. , Alekseev V.A.
Published: November 2023

A laboratory prototype of a hybrid plasma filter based on live hepatocytes for extracorporeal correction and normalization of biochemical blood parameters in patients with liver failure was made. The results obtained demonstrate promising results for further work in order to fabricate a biological circuit for clinical use.
IDENTIFICATION OF TRANSGENE INTEGRATION REGIONS IN THE ARABIDOPSIS THALIANA GENOME, PROVIDING A HIGH YIELD OF THE RECOMBINANT PROTEIN
Authors:   Institute of Cytology and Genetics SB RAS, Novosibirsk, Tsmokalyuk D.A. , Zagorskaya A.A. , Belavin P.A. , Uvarova E.A. , Deineko E.V.
Published: November 2023

This work summarizes the results of genomic safe harbor method implementation for increasing recombinant protein yield in the transgenic plants. A collection of transgenic Arabidopsis thaliana plants was assessed for recombinant protein accumulation level. For plants with superior accumulation level (up to 0,8 % of total soluble protein) adjacent to transgene genomic sequences were defined.
ANTIOXIDANT AND ANTIPLATELET PROPERTIES OF NANOPARTICLES WITH LIPOIC ACID
Authors:   MIREA — Russian Technological University, Moscow, Shchelkonogov V.A. , Inshakova A.M. , Darnotuk E.S. , Shipеlova A.V. , Shastina N.S. , Baranova O.A. , Chekanov A.V. , Kazarinov K.D. , Soloveva E.Yu. , Fedin A.I. ,   Pirogov Russian National Research Medical University, Moscow,   Kotelnikov Institute of Radio Engineering and Electronics RAS, Fryazino
Published: November 2023

Nanoparticles (NPs) with lipoic acid (LA) with a particle size 25–350 nm were obtained, characterized by its slow release from nanodispersions and high stability during long-term storage at room temperature. In nanoemulsions, it was possible to solubilize LA by 1.5 times than in liposomes. It was shown that NPs with LA have pronounced antioxidant and antiplatelet properties.
Keeping an “eye” on the experiment: computer vision for real-time monitoring and control
Authors: El-khawaldeh Rama , Guy Mason , Bork Finn , Taherimakhsousi Nina , Jones Kris , Hawkins Joel , Han Lu , Pritchard Robert , Monfette Sebastien , Hein Jason
Published: November 2023

This work presents a generalizable computer vision (CV) and machine learning model that is used for automated real-time monitoring and control of a diverse array of workup processes. Our system simultaneously monitors multiple physical parameters (e.g., liquid level, homogeneity, turbidity, solid, residue, and color), offering a method for rapid data acquisition and deeper analysis from multiple visual cues. We demonstrate a single platform (consisting of CV, machine learning, real-time monitoring techniques, and flexible hardware) to monitor and control vision-based experimental techniques, including solvent exchange distillation, antisolvent crystallization, evaporative crystallization, cooling crystallization, solid ̶ liquid mixing, and liquid ̶ liquid extraction. Both qualitative (video capturing) and quantitative data (parameters measurement) were obtained which provided a method for data cross-validation. Our CV model's ease of use, generalizability, and non-invasiveness make it an appealing complementary option to in situ and real-time analytical monitoring tools and mathematical modeling. Additionally, our platform is integrated with Mettler-Toledo’s iControl software, which acts as a centralized system for real-time data collection, visualization, and storage. With consistent data representation and infrastructure, we were able to efficiently transfer the technology and reproduce results between different labs. This ability to easily monitor and respond to the dynamic situational changes of the experiments is pivotal to enabling future flexible automation workflows.
Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors
Authors: Governa Paolo , Biagi Marco , Manetti Fabrizio , Forli Stefano
Published: November 2023

ATP-binding cassette (ABC) transporters are a large family of proteins involved in membrane transport of a wide variety of substrates. Among them, ABCB1, also known as MDR-1 or P-glycoprotein (P-gp), is the most characterized. By exporting xenobiotics out of the cell, P-gp activity can affect the ADME properties of several drugs. Moreover, P-gp has been found to mediate multidrug resistance in cancer cells. Thus, the inhibition of P-gp activity may lead to increased absorption and/or intracellular accumulation of co-administered drugs, enhancing their effectiveness. Using the human cryoEM 3D structure of the P-gp in the inhibitor-bound intermediate form (PDBID: 6qee), approximately 200'000 commercially available natural compounds from the ZINC database were virtually screened. To build a model able to discriminate between substrate and inhibitors, two datasets of compounds with known activity, including P-gp inhibitors, substrates, and inactive molecules were also docked. The best docking pose of selected substrates and inhibitors were used to generate 3D common feature pharmacophoric models that were combined with the Autodock Vina binding energy values to prioritize compounds for visual inspection. With this consensus approach, 13 potential candidates were identified and then tested for their ability to inhibit P-gp, using zosuquidar, a P-gp inhibitor of clinical use, as a reference drug. Eight compounds were found to be active with 6 of them having an IC50 lower than 5 µM in a membrane-based ATPase activity assay. Moreover, the P-gp inhibitory activity was also confirmed by two different cell-based in vitro methods. These results demonstrate the ability of the combined structure-based pharmacophore modeling and docking-based virtual screening approach to predict novel hit compounds with inhibitory activity toward P-gp. The resulting chemical scaffolds could serve as inspiration for the optimization of novel and more potent P-gp inhibitors.
Traversing Chemical Space with Active Deep Learning
Authors: van Tilborg Derek , Grisoni Francesca
Published: November 2023

Deep learning is accelerating drug discovery. However, current approaches are often affected by limitations in the available data, e.g., in terms of size or molecular diversity. Active learning is poised to be a solution for drug discovery in low-data regimes. In active learning, a model is updated iteratively by taking multiple smaller screening steps, instead of suggesting many molecules at once with a single model for traditional ‘one-shot’ screening. This iterative approach aims to improve models during the screening process and can adjust course along the way. Despite pioneering applications, it is currently unclear how active learning holds up to traditional approaches and what the best strategies are for prospective drug discovery applications. In this study, we combine six active learning strategies with two distinct deep learning methods and analyse their performance on three large-scale libraries. For each strategy, we investigate its capacity to discover bioactive hits and explore the chemical space. We found that active learning can achieve up to a six-fold improvement in hit retrieval compared to traditional methods in a low-data scenario. The strategy to acquire new molecules at each cycle resulted to be the primary driver of performance, and it determined the ‘molecular journey’ throughout screening cycles. Finally, we show that active learning can quickly compensate for a lack of molecular diversity in the starting set. These results advocate for the adoption of active deep learning to accelerate drug discovery in low-data regimes.
From Traditional Librarian to Scholar in the Field of Information and Documentation Sciences
Authors:   “Mihai Eminescu” Central University Library, Iași, Olariu Ivona , Szekely Adriana ,   “Lucian Blaga” Central University Library, Cluj-Napoca
Published: November 2023

"The present article comprises the results that synthesise the current professional training preferences of the members of the Romanian Library Association (RLA). The directions of professional development have emerged from a survey conducted between September and November 2022, on a national-level representative sample. The professionals in the field were approached on the matter of their motivation to participate in the training programmes and of the extent of the importance they confer to professional training, as well as their expectations after the completion of the aforementioned programmes and the level of their involvement in such endeavours over the past 3 years (financial resources, allotted time). The analysis focused on the training topics chosen by the respondents, the criteria based on which the programmes had been selected, the difficulties that had been encountered etc. In order to outline a comprehensive view on the evolution of the RLA members’ preferences, a comparison was made between the current results and the ones obtained in 2016 by a similar study. The analysis also covers the differences that occurred during the pandemic period, which emphasised the necessity for certain approaches that were different with respect to the means of exercising the profession, which implicitly led to the acquisition of new skills and abilities."
Current Situation and Improvement Strategies of Teaching Engagement by Teachers in Higher Medical Colleges Under the Background of “New Medical Education”
Authors: Jia Yuanyuan , Cai Yu , Wu Ge , Wang Siqi , Tian Chang , Feng Yu
Published: November 2023

The “New Medical Education” is a new requirement for the development of medical education in the new era. As a key and core element of the construction of the “New Medical Education,” the engagement in teaching work of university teachers is a key issue that determines the level of teaching development of university teachers and affects the quality of talent cultivation in universities. Using the literature review method, this study analyzed 39 relevant literatures retrieved from China National Knowledge Infrastructure (CNKI) from 1997 to 2023. The concept, connotation, current situation, influencing factors, and improvement strategies of teaching engagement by university teachers were reviewed and summarized. The results showed that the issue of teaching engagement by university teachers has not received high attention in the field of higher education, especially in higher medical education, which has not yet been reported. Although the overall number of literature is not large, some of the conclusions have important implications for the next research on the influencing factors and mechanisms of double-qualified teacher engagement in higher medical colleges.
Polymorphism of allelic variants of milk protein genes
Authors: Ilina Anna Vladimirovna , Abramova Marina Vladimirovna , Evdokimov Evgeniy Georgievich
Published: November 2023

The polymorphism of allelic variants of milk productivity genes (alpha-lactoglobulin, beta-casein, kappa-casein, prolactin, somatotropin) in cattle of the yaroslavl breed was studied in conjunction with an assessment of the genetic diversity of the studied population. The distribution of frequencies of occurrence of genotypes in the genes of the studied herds (0.1...0.716049) was determined. Based on the calculations of the average values ??of the genetic diversity indices, the effective number of alleles (1.679...1.994), the Shannon information index (0.594...0.692), the observed heterozygosity (0.087...0.716), the expected heterozygosity (0.404...0.498), fixation index (-0.498...0.823).The coefficient of inbreeding of subpopulations in the studied genes relative to the entire population indicates a weak differentiation of different herds (-0.023 ... -0.002). According to the analysis of the equilibrium distribution of genotypes according to the Hardy-Weinberg law, it is noted that the largest part of the herds has an equilibrium distribution of genotypes. The exception is yaroslavka breeding Plant JSC for the A1A2 beta-casein gene (20.095) and Agromir LLC (Mikhailovskoe branch) for the beta-casein gene (15.581).
Theoretical substantiation of optimal geometric parameters of the nozzle of a jet fan rain-forming nozzle for watering champignons
Authors: Azizov Irek Railevich , Rusinov Alexey Vladimirovich , Chumakova Svetlana Valentinovna , Anisimov Sergey Aleksandrovich
Published: November 2023

The materials of the article consider theoretical studies of optimal geometric parameters of the nozzle of a jet fan rain-forming nozzle for watering champignons and experimental substantiation of the results obtained.
Adaptive capabilities seedless grape varieties in a sharply continental climate
Authors: Polukhina Elena Vladimirovna
Published: November 2023

The article presents the results of the study of winter hardiness, drought resistance, heat resistance of seedless grape varieties at the initial stages of culture development in a sharply continental climate. The purpose of the research was to study and identify promising highly adaptive seedless grape varieties with a complex of economically valuable traits for cultivation in arid conditions of the North-Western Caspian Sea. The objectives of the research included: determination of the degree of winter hardiness of introduced grape varieties; assessment of drought resistance and heat resistance of the studied seedless varieties. The research was carried out in 2021...2022 at the vineyard of the Precaspian agrarian federal scientific center of the Russian academy of sciences, located in the Chernoyarsk district of the Astrakhan region. The object of research was 16 seedless grape varieties planted in 2020. The Radiant variety, zoned in the Lower Volga region, was adopted as the standard. It was found that, on average, over two years of research, the maximum degree of winter hardiness was characterized by varieties Golden, Lucia, Rose and Century with the safety of eyes after overwintering from 61.4 to 70.9 %. Varieties Radiant, Azak, Attica, Aphrodite, Ballet, Veles, Zolotce, Iskander, Nakhodka, Neptune, Tangra, Himrod, Jupiter they had an average degree of winter hardiness – from 43.1 to 58.1 %. The varieties Azak, Attica, Ballet, Zolotce, Iskander, Lucia, Neptune, Himrod, Jupiter were characterized by maximum resistance to stress factors of the summer period in the third year of vegetation. The most heat-resistant varieties were Zolotce, Century, Himrod, Jupiter, which lost the least amount of water during wilting (24.2...28.6 %) and, to a greater extent, restored hydration at saturation (60.2...87.9 %).
Simulation of slotting conditions on irrigated lands in the south of Russia under increasing climate change
Authors: Bandurin Mikhail Aleksandrovich , Sukharev Denis Vladimirovich , Prikhodko Igor Aleksandrovich , Komsyukova Yana Alekseevna
Published: November 2023

The article considers the results of numerical studies on the improvement of existing tillage tools, namely, the improvement of the technical parameters of the furrower, which will improve the water-physical properties of irrigated lands in southern Russia with increasing climate change. Every year, the areas of irrigated land are reduced as they are exposed to natural (for example, rains; floods; surface runoff; diversity of soil cover, the influence of micro- and macrorelief) and anthropogenic (for example, non-compliance with irrigation norms, crop rotation composition, soil cultivation rules; introducing incorrect doses of fertilizers; exclusion of technological operations in order to save resources) factors. In this regard, the solution to the problem of preserving the agro-resource potential of the lands is relevant, and its solution guarantees the food security of Russia. Numerical modeling of dangerous loadings of the technical parameters of the slotter-furrower has been carried out, the types and types of equipment have been selected, their parameters have been calculated, as well as the organization and technology of tillage processes.
Justification of the parameters of the rotary vane device for the orientation of beetroot during their planting
Authors: Ovtov Vladimir Aleksandrovich , Chirkova Natalya Sergeevna , Gorshkov Kirill Andreevich , Tsurenko Pavel Denisovich
Published: November 2023

The existing market of sugar beet seeds shows a significant dependence of Russian agricultural entities engaged in the cultivation of sugar beet on the supply of hybrids of foreign agricultural firms, mainly from the European Union. First of all, this is due to the fact that over the past decades, capital investments in the material and technical base of breeding and seed production on the part of the state were insignificant, which led to the aging of the seed technology used. As is known, the most labor-intensive operation of the technological process associated with the production of sugar and fodder beet seeds is their planting, which is least mechanized and requires a lot of human labor spent on the selection, orientation of root crops and supply them into the planted cones of planting machines with subsequent embedding in the soil with the sharp end down. Currently, a planting machine MV-2.8 is used for planting sugar beet root crops, which is serviced by four people. Consequently, research related to the mechanization of orientation and feeding of root crops into planting cones without the participation of planters is relevant. The article presents a 3D model of a rotary vane device of a planting machine for orienting conical root crops and feeding them into the planting cones of the planting apparatus. At the same time, with a vane length of 280 mm, its thickness will be 11.9 mm, and the greatest deflection is no more than 3 mm, which will ensure the orientation of root crops and their supply to the planting cones of the planting apparatus.
The effectiveness of using a trichogram to protect corn from cotton scoops in the Left bank of the Saratov region
Authors: Chistin Mikhail Igorevich , Likhatskaya Svetlana Gennadievna , Eskov Ivan Dmitrievich
Published: November 2023

The article presents data on the biological effectiveness of the use of the parasitic entomophage trichogram on corn crops to control the number of Helicoverpa armigera Hbn. In 2021, the average number of cotton scooper larvae was 7.4 per 100 plants. The double release of the trichogram on corn crops in 2021 made it possible to significantly reduce the number of phytophagous eggs. The biological efficiency of the first release of a parasitic insect averaged 42.6%, the second is 89.0%.
The effect of the zinc preparation "Asparzink" on the morphological parameters of pheasant blood
Authors: Novikova Maria Vyacheslavovna , Pudovkin Nikolai Aleksandrovich , Zakharkina Natalia Ivanovna
Published: November 2023

The article presents the results of studies on the effect of the drug "Asparzink" on the morphological parameters of pheasant blood. For the prevention of zinc deficiency conditions, various additives have been often used recently. One of them is "Asparzink", which includes zinc asparginate. However, its effect on blood morphological parameters has not been fully established. The aim of the work was to study the effect of the zinc preparation "Asparzink" on the morphological parameters of pheasant blood. The studies were carried out on pheasants of the North Caucasian breed. Pheasants were kept in the conditions of the GBU of JSC "Directorate of Southern PLO and GOH "Astrakhan". Hematological parameters were determined on Mindray BC-2800 Vet (China). It was found out that the studied compound has a pronounced positive effect on the morphological parameters of peripheral blood, which is expressed by an increase in the number of red blood cells by 18.7 and 19.3%, hemoglobin levels by 10.7 and 14.6%, average volume of red blood cells by 12.0 and 13.8%, hematocrit levels by 13.9 and 19.4% when administered at a dose of 1 and 2 mg/kg, respectively. An increase in the number of monocytes and basophils was determined. The most effective dose is 2 mg/kg of body weight.
Biological value of the meat protein of Edilbaev lambs when enriching diets with es-sential microelements
Authors: Irina Aleksandrovna  , Molchanov Aleksandr Vyacheslavovich , Sazonova Svetlana Olegovna , Chemodankin Sergey Nikolaevich
Published: November 2023

The article presents the results of studying the quality and usefulness of the protein in meat products obtained from lambs of the Edilbaev breed. The experiment involved one control and three experimental groups of animals, the diet of which was enriched with essential microelements in the form of feed additives "Yoddar-Zn" and "DAFS-25". The results of the research showed that in the rams of the experimental group, which were fed in combination with the main diet supplements Ioddar-Zn and DAFS-25, the maximum amino acid score and protein-quality index were noted, which indicates a high biological value of meat. According to the coefficients of utility and comparable redundancy, it is assumed that in the meat of rams from the control group, amino acids are better balanced and can be more rationally used by the human body. Among the experimental groups of young sheep, the meat of the experimental group, where two feed additives were used at once, had the best rationality.
Analysis of the results of laboratory tests of the system of automatic control of the illumination of the led light
Authors: Anashkin Anatoly Aleksandrovich , Anashkin Anton Anatolievich , Ugarov Gennady Grigiroevich , Bakirov Sergey Mudarisovich , Strelnikov Vladimir Aleksandrovich
Published: November 2023

The article discusses the results of experimental data on the response of a photoconverter under the influence of radiation reflected from the working surface of various light sources (LED light source, incandescent lamp, fluorescent lamp, natural light source - the sun). The results of mathematical planning by three-factor and two-factor experiments are presented. As a result of the tests, it was found that when calibrating the automatic illumination control system for an LED lamp, when creating the same illumination on the working surface, the illumination coefficient should be taken into account. If the working surface is additionally affected by a solar light source, then an illumination coefficient of 3.99 is taken to calculate the resulting output signal; for fluorescent lamps - 3.38; incandescent lamps - 1.71.
Fractal structure analysis and mechanical properties of elastomer nanocomposite for recovery of technical parts
Authors: Li Roman Innakentievich , Psarev Dmitry Nikolaevich , Melnikov Anton Yurievich
Published: November 2023

The article considers the results of fractal analysis of the structure of elastomeric nanocomposites in the form of molecular and structural characteristics, as well as their experimentally determined mechanical properties. The optimal composition is determined, at which the nanocomposite has the highest mechanical properties. In comparison with the unfilled F-40S elastomer, the strength of the nanocomposite increased by 32%, and the deformation increased by 1.66 times.
The use of modern digital devices for fixing the parameters of movement of agricultural units
Authors: Us Semyon Sergevich , Marshanin Evgeniy Vladimirovich , Kuznetsov Konstantin Evgenievich , Kuznetsov Evgeniy Evgeievich , Shchitov Sergey Vasilievich
Published: November 2023

Despite a significant range of methods for determining mechanical failures known in modern industries, the issue of large-scale use and expansion of the scope of modern digital devices and instrumentation systems, which previously had rather limited specifics in the form of individual elements of control systems, remains relevant as before. Taking into account that in the modern state of technology, high-tech digital solutions are most in demand, capable of carrying out in-place research and fixing the operating parameters of complex systems and units used in the agro-industrial complex at a qualitative level and with a minimum time spent on diagnostic work or testing, it seems to be the most promising the use of digital inclinometers, with their low cost, manufacturability and availability, providing significant opportunities for measuring and fixing the design and technological parameters of a complex, machine or unit. The article substantiates the use of a high-precision inclinometric complex both for carrying out diagnostic work and for measuring the necessary parameters of a technological complex in motion and presents the results of experimental studies.
Feeding microalgae is the key to increasing the economic efficiency of milk production
Authors: Vasiliev Alexei Alekseevich , Syrovatskiy Maxim Viktorovich , Kurilova Nina Mikhailovna
Published: November 2023

The article discusses the results of feeding green microscopic aquatic plants Chlorella Vulgaris to black-and-white cows. Drinking a suspension of chlorella to fresh cows for 99 days of lactation showed that feeding a suspension of chlorella kept the average daily milk yield of the cows of the experimental group, in the transitional spring-summer season, at a high level during the entire accounting period. The average daily milk yield in the experimental group of first-calf heifers was 9.3 % higher than in the experimental group. This made it possible to milk in the experimental group, on average, one head more milk in its natural form than in the control group by 250.5 liters. Additional milk yield in the experimental group, in terms of the basic milk fat content of 3.4 %, amounted to 547.5 liters, and the profit from the sale of this milk per 1 head of the experimental group was more by 16.6 thousand rubles, compared with the control. The use of chlorella suspension in feeding cows of the 2-nd and 3-rd lactations shows that 534.2 liters of milk can be additionally obtained from one cow in 99 days, based on a basic fat content of 3.4 %. Additional profit from the sale of milk per 1 cow, in this case, will be 16.1 thousand rubles.
Influence of various dosages of probiotic "Cellobacterin-T" on biochemical indicators of chicken blood
Authors: Prytkov Yuri Nikolaevich , Kistina Anna Aleksandrovna , Ageev Boris Vladimirovich
Published: November 2023

The article presents data from experimental studies on the effect of various dosages of the Cellobacterin-T probiotic in the diets of laying hens on hematological parameters. It was established that the use of the probiotic additive Cellobacterin-T in the compound feed at the rate of 100 mg/100 g contributed to an increase in the content of hemoglobin and erythrocytes at 30 weeks, respectively, by 2.2 and 13.3%; at 46 weeks - by 2.9 and 3.7%; at 64 weeks - 1.9 and 1.8% compared to the control group. The inclusion of the supplement somewhat changed the content of total protein in the blood serum, the level of protein in the blood was more at 30 weeks by 3.4%; at 46 weeks - by 3.9%; at 64 weeks - by 3.1%. To improve the physiological status of laying hens, it is recommended to include the probiotic feed additive "Cellobacterin-T" in the compound feed at a dosage of 100 mg/100 g of compound feed by stepwise mixing.
The use of medicinal plants in the diets of lactating cows
Authors: Lashkova Tatiana Borisovna , Petrova Galina Vasilievna
Published: November 2023

In studies conducted on the territory of a farm belonging to the Novgorod Research Institute on Ayrshire cows during lactation, the use of plants with medicinal properties – crushed leaves of stinging nettle and fruits of red mountain ash for forcing the excretion of cesium and potassium radionuclides through the gastrointestinal tract and kidneys was studied. Seven groups of cows were selected for the research (n = 10 in each). For animals of the first three groups, in addition to the main feed, crushed nettle leaves were used (5, 10 and 30 g/head/day), for the next three groups, crushed rowan berries (5, 10 and 30 g/head/day) were used. For animals of the control group, a set of feeds was used, established and adjusted for this farm. It was found that when using herbal supplements in the diet, the concentration of caesium-137 in the urine of animals of all experimental groups significantly exceeded the control indicators. The content of potassium-40 in the urine of the fourth experimental group exceeds the control by 43%, in the rest the indicator is stable. In the feces of cows of the experimental groups, there is a significant increase in the concentration of both caesium-137 (from 31 to 136% relative to the control) and potassium-40 (from 24 to 166%). Accordingly, the release of radionuclides by the gastrointestinal tract and kidneys in the experimental groups is more active, relative to the indicators of the control groups. In some cases, more radionuclides were excreted than were ingested with food.
Indicators of metabolism in the body of purebred and crossbred yearlings
Authors: Pogodaev Vladimir Anikeevich , Kits Elena Aleksandrovna
Published: November 2023

The need to improve the genetic potential of sheep in the meat direction is dictated by increasing the efficiency of sheep breeding due to the production of high -quality lamb. Why in recent years, meat sheep, including Dorper breed sheep, have been imported to Russia. In this connection, with which a comprehensive study of the monthly animals obtained by inter -ended crossing of the sheep of the Kalmyk Kurdishporoda and the Dorper breed is relevant. The aim of this work was to determine the characteristics of metabolism in the body of purebred and monthly re-obtained, obtained as a result of crossing the purebred female individuals of the Kalmyk fatty breed with male individuals of the Dorper breed. Scientific and production experience was conducted during 2022 on the basis of the KFK "Arl", the Republic of Kalmykia, where two re-sampling were formed from the general number of sheep, the experimental groups of the re-yield, which includes 15 heads of purebred animals of the Kalmyk fatty breed and 15 heads of estates Perevyariki of blood of which was a 1/2 -Kilmy Kurdish breed and 1/2 Dorper breed. It was established that the horses are superior to the purebred peers of the Kalmyk chicken rock through the breed that the estates surpass the purebred peers in the total blood serum of the protein by 2.33 %, its albumin faction by 7.02 %, and the ? and ?-globulin fractions At 9.54 and 2.10 %, respectively. According to the activity of alanine aminotransferase  by 8.16%, aspartate aminotransferase by 6.67 %, concentration of urea by 5.7 %, in terms of creatinine is 20.6 %. This indicates that they have a more intense nitrogen metabolism, and therefore more active protein metabolism. The absence of intergroup distinctions established by the studies in the content of glucose in the blood serum is explained by the fact that they have an equal ability to absorb carbohydrates from feed and preservation of glucose in the blood, which is one of the most perfect mechanisms.
Traction resistance study of the stuff seeder SKP-2.1
Authors: Shmidt Andrey Nikolaevich , Kem Aleksandr Aleksandrovich , Damanskij Roman Viktorovich , Mikhaltsov Evgeny Mikhailovich , Soyunov Aleksey Sergeevich
Published: November 2023

The article presents the results of a study of the traction resistance of a stubble grain planter-cultivator SKP-2.1 with mass-produced standard foot coulters and experimental combined coulters of the design of the Omsk ANC. Comparative studies were carried out on an aggregate consisting of the MTZ-82.1 tractor + the SKP-2.1 seeder according to the stubble agrophone from the previous crop – wheat. The speed of the unit: 7, 9, 11 km/h. Stroke depth of working bodies: 0.04, 0.06, 0.08 m. The study of the traction resistance of the seeder was carried out using the information-measuring system EMA-PM and the strain gauge link. It was found that the traction resistance of a drill with experimental combined coulters at a speed of 9 km/h and a sowing depth of 0.04 m is 33.3 % less than that of a drill with standard foot coulters; at the same speed and sowing depth of 0.06 m, the difference was 13.8 % in favor of a combined coulter. With an increase in the sowing depth to 0.08 m, the traction resistance of the combined coulter is only 3 % less.