bluuebunny/crossref_metadata_2025 huggingface dataset:
ПРИСУТНІСТЬ ВІДЧУТТЯ РАДОСТІ ЯК ЖИТТЄСТВЕРДЖУЮЧИЙ КОМПОНЕНТ ОСОБИСТОСТІ В УМОВАХ НЕВИЗНАЧЕНОСТІ
Authors: Панченко О. А. , Кабанцева А. В. , Стеценко Г. В.
Published: October 2023

У статті розглянуто питання прояву відчуття радості як одного з базових компонентів особистості який відображає її ментальне здоров’я у проживанні невизначеності, що є характерною для періоду воєнного стану в Україні. Наведено результати дослідження актуального функціонування респондентів, що вміщує психологічну, фізичну, соматичну та інформаційну складові. Розглянуто прояви емоційних станів, відношення населення до інформації, їх потреба у радості та джерела її отримання. Зроблено порівняння результатів між трьома групами респондентів, які проживають на різних відстанях від територій активних бойових дій, зокрема: особи з числа вимушено переміщених осіб (І група), мешканці прифронтової зони (ІІ група) та особи, які проживають у центральному регіоні України (ІІІ група). Встановлено, що у всіх трьох групах переважав загальний психоемоційний стан з тенденцією до негативного, але у першій групі проявлялася збільшена тенденція до позитивного стану. Клінічно виражений рівень тривоги мав однакові показники у всіх трьох групах по 26% відповідно. Ознаки депресії на високому клінічному рівні переважали у мешканців центрального регіону – 29%. Респонденти з усіх груп мали однаково високу потребу в радості, а ось джерела радості мали відмінності. Виявлено зворотній кореляційний зв’язок між відчуттям радості та депресією (r=-0,568, p<0,01) та непрямий зв’язок з тривогою (r=-0,373, p<0,01). Прямий кореляційний зв’язок встановлено між відчуттям радості та загальним емоційним станом (r=0,475, p<0,01). Місце перебування мешканців істотно не впливало на їх психоемоційний стан, оскільки люди всюди відчували небезпеку, але поряд із цим, респонденти гідно приймали виклики долі і намагалися самостійно справлятися з ними.
HACIA LA GESTIÓN ÁGIL
Authors: Niezwida Sonia Romina , García Bárbaro Nora Adriana , Michalus Juan Carlos
Published: October 2023

En el presente artículo se expone un estudio de caso con diagnóstico, análisis y resultados tras incorporar la polivalencia y polifunción en el sector de logística de una PyME (Pequeña y Mediana Empresa) distribuidora de alimentos ubicada en la provincia de Misiones, de la República Argentina, como aplicación desde el punto de vista de la gestión ágil y la manufactura esbelta. El trabajo comenzó en la época de pandemia por el COVID-19, situación que obligó a la empresa a implementar cambios en la forma de operación debido al riesgo que conllevó la falta de operarios por enfermedad, en especial en sectores donde había una sola persona con conocimiento de la operación, que llevó al detenimiento del servicio y situación de caos en el proceso de reparto de mercaderías, debido a la ausencia de personas clave. El objetivo del estudio es mostrar el método utilizado para la lograr operarios multifunción mediante el uso de herramientas de metodologías ágiles. En el escrito, se muestra como ubicar las situaciones de caos mediante Cynefin, se desarrolla una matriz de policompetencias y se muestran los criterios utilizados para lograr la polifunción de operarios en el área de reparto de la empresa, en la cual se pudieron notar mejoras significativas, tanto en la gestión del proceso, como en los indicadores tomados como referencia para la medición de dichas mejoras.
 
En el presente artículo se expone un estudio de caso con diagnóstico, análisis y resultados tras incorporar la polivalencia y polifunción en el sector de logística de una PyME (Pequeña y Mediana Empresa) distribuidora de alimentos ubicada en la provincia de Misiones, de la República Argentina, como aplicación desde el punto de vista de la gestión ágil y la manufactura esbelta. El trabajo comenzó en la época de pandemia por el COVID-19, situación que obligó a la empresa a implementar cambios en la forma de operación debido al riesgo que conllevó la falta de operarios por enfermedad, en especial en sectores donde había una sola persona con conocimiento de la operación, que llevó al detenimiento del servicio y situación de caos en el proceso de reparto de mercaderías, debido a la ausencia de personas clave. El objetivo del estudio es mostrar el método utilizado para la lograr operarios multifunción mediante el uso de herramientas de metodologías ágiles. En el escrito, se muestra como ubicar las situaciones de caos mediante Cynefin, se desarrolla una matriz de policompetencias y se muestran los criterios utilizados para lograr la polifunción de operarios en el área de reparto de la empresa, en la cual se pudieron notar mejoras significativas, tanto en la gestión del proceso, como en los indicadores tomados como referencia para la medición de dichas mejoras.
DIAGNÓSTICO DE LA EXPORTACIÓN DE PRODUCTOS Y SERVICIOS DE PARAGUAY- AÑO 2022
Authors: Wiesenhutter Mariane , Lopez Guadalupe
Published: October 2023

Esta investigación tuvo como objetivo diagnosticar la exportación de productos y servicios de Paraguay en el año 2022 debido a que las exportaciones han aumentado en los últimos años, generando un impacto positivo en la balanza comercial del país. La metodología tuvo enfoque cuantitativo, descriptivo y no experimental, puesto que se estudiaron datos numéricos existentes y se compilaron informaciones referentes a la exportación de distintos productos. La recolección de los datos fueron de fuentes secundarias, documentales: Banco Central del Paraguay (BCP), Servicio Nacional de Salud Animal (SENACSA), Cámara Paraguaya de Exportadores y Comercializadores de Cereales y Oleaginosas (CAPECO), Trade - Map y Penta Transaction, Ministerio de Industria y Comercio (MIC), Dirección Nacional de Aduanas (DNA) y fueron analizados a través de la técnica de la estadística descriptiva sobre las variaciones monetarias en miles de dólares americanos y el volumen exportado en kilogramos. Los resultados evidenciaron que las exportaciones aumentaron en chía, arroz, semilla de oleaginosas, yerba mate, madera, trigo, carne bovina y petitgrain como consecuencia de las condiciones climáticas, también incrementaron los servicios de Maquila, mientras que disminuyeron las exportaciones de banana, soja, aceite de soja, almidón de mandioca, harina de soja, por la sequía y bajante del río pero con remonte del precio unitario, por lo tanto, el sector de producción de materia prima crece y logra ser reconocido por distintos países por su calidad y duración, lo cual se ha vuelto fundamental para los productores y la economía del país fortalecer las integraciones y exportaciones a mercados internacionales.
POLÍTICAS SOCIAIS, ASSISTÊNCIA SOCIAL E APAES
Authors: Szelbracikowski Karen , Rotta Edemar
Published: October 2023

O presente artigo analisa as Associações de Pais e Amigos dos Excepcionais (APAES) da Região das Missões/RS em sua inserção na Política Nacional de Assistência Social (PNAS). Tem como objetivo compreender as contribuições dadas pelas APAES da Região das Missões/RS na garantia dos direitos sociais às pessoas com deficiência, no âmbito da PNAS. Se trata de pesquisa com abordagem fundada no método dialético-crítico, com prisma qualitativo, de natureza aplicada e caráter exploratório, realizada através de pesquisa bibliográfica, estudo de documentos e levantamento de dados empíricos via questionário eletrônico. Os materiais coletados foram analisados via técnica de análise de conteúdo. Estabelece-se uma articulação entre os conceitos de políticas sociais, assistência social e APAES, relacionando-os aos direitos sociais. Evidencia-se a realidade concreta das dez APAES das Missões/RS. Quanto à historicidade, cinco das APAES dessa Região foram criadas antes da promulgação da CF/88, e as outras cinco após esse período. Em termos de estruturas físicas e recursos humanos evidencia-se que a maioria possui prédios próprios e os profissionais são contratados, predominantemente, por vínculo celetista, havendo em todas elas assistente social. No tangente aos recursos financeiros, percebe-se que as suas principais fontes estão nos recursos municipais. No tocante aos serviços socioassistenciais constatou-se que todas elas trabalham na área da política de assistência social, enquanto cinco delas atuam na política de educação e três delas trabalham na área de saúde. Quanto às PCDS, essas APAES atendem, preferencialmente, às intelectuais e múltiplas, mas também às pessoas com deficiências visuais, físicas, auditivas, entre outras.
MOVIMENTOS SOCIAIS E AS PREOCUPAÇÕES AMBIENTAIS E SOCIAIS
Authors: Rotta Edemar , Gerhardt Milton César
Published: October 2023

O presente artigo discute a temática dos movimentos sociais e suas preocupações ambientais e sociais. As questões que envolvem esses diferentes atores perfazem as reivindicações nos diferentes campos da sociedade, abordando temas que remetem à vida do planeta. Os movimentos sociais, hoje situados e envolvidos em redes e fóruns de cooperação, assumiram questões novas e que demandam profundas investigações. Há, contudo, uma grande articulação entre as redes de movimentos sociais que na atualidade se caracterizam em unir heterogeneidades dos múltiplos atores coletivos em torno das pautas e lutas em questão. Em meio aos diferentes enfoques de frentes de lutas que abordam a questão ambiental, o recorte deste artigo recai sobre o tema das mudanças climáticas, propondo refletir acerca de como se pode conjugar a vida e a economia, que implica produzir e distribuir, procurando integrar e valorizar essas questões de modo a preservar o meio que habitamos com as diferentes organizações sociais existentes. Reconhecendo as diferentes iniciativas, experiências e pesquisas dos caminhos de conscientização da temática ambiental, o desafio é avançar cada vez mais para o cuidado do planeta. Em tempos que se vê o ser humano e o planeta ameaçados, se faz necessário outras formas de pensar e organizar a vida como expressão de um todo. A ética como uma reflexão profunda sobre a vida pode auxiliar no sentido de apontar reflexões sobre os valores e fins a serem buscados como meios de conseguir uma transformação do modo de vida, atualmente pautado pelo ter e não pelo ser.
Efektivitas Penggunaan Serbuk Cangkang Telur Ayam Sebagai Penetralisir Derajat Keasaman dan Kekeruhan Pada Air Limbah Industri Makanan
Authors: Baharsyah Affan Ananda , Sabdiansyah  , Munira  , Suryanto Andi
Published: October 2023

Chicken egg shells are food waste that is usually produced from household activities, which has an impact on environmental pollution. Chicken egg shells are known to have a high calcium carbonate (CaCO3) content that can be utilized. The purpose of this study was to determine the pH and turbidity of food industry waste water and to determine the best mass of chicken eggshell flour as a filter media. This research was conducted in a filter column where the wastewater samples that entered the filter column would pass through the prepared chicken egg shell filter media with several mass variations, namely 50 g, 100 g, 150 g, 200 g, and 250 g
ІНКЛЮЗИВНО-РЕСУРСНІ ЦЕНТРИ В УМОВАХ ВІЙНИ: ОКРЕМІ ПИТАННЯ ОСВІТИ ДІТЕЙ З ОСОБЛИВИМИ ПОТРЕБАМИ
Authors: Прохоренко Леся
Published: October 2023

У статті теоретично обґрунтовано основні проблеми в освіті осіб з особливими освітніми потребами (ООП) в умовах воєнного стану. Проаналізовано підходи доступності і дитиноцентризму, які є ключовими у моделі освіти України, що передбачають такі характеристики якості, як рівний доступ до навчання, ефективний навчальний процес, безпечне і здорове навчальне середовище; участь усіх учасників навчального процесу у шкільному менеджменті; багаторівнева громадська взаємодія тощо. Зазначено, що рівноправний доступ до якісної освіти, у тому числі осіб з особливими потребами, є міжнародною програмою, в якій запропоновано п’ять вимірів освітньої якості: ефективність, продуктивність, рівність і відповідність (вимогам учнів, їх сімей і вимогам суспільства). В Україні на цьому шляху здійснено чимало змін як на рівні законодавства, так і на рівні практики: внесені зміни в основні Закони України про розвиток і впровадження інклюзивної освіти; створені умови для навчання дітей і молоді з особливими освітніми потребами на базі багатьох дошкільних, загальноосвітніх і вищих навчальних закладів, розвинуто мережу інклюзивно-ресурсних центрів, які визначають для осіб з особливими потребами індивідуальний освітній вектор в умовах інклюзивного освітнього середовища тощо. Обґрунтовано сучасний практичний досвід функціонування ІРЦ в умовах війни, що зумовлює потребу у проведенні емпіричних розвідок, узагальненні результатів, а також визначенні тих умов діяльності ІРЦ, дефіцит яких негативно впливає на весь процес супроводження осіб з особливими потребами. Зокрема, йдеться про: розроблення інноваційних підходів до системного кваліфікованого супроводу та надання психолого-педагогічних і корекційно-розвивальних послуг особам з особливими освітніми потребами в умовах війни та повоєнного відродження; удосконалення нормативно-правового, методичного, кадрового забезпечення інклюзивно-ресурсних центрів; оновлення психолого-педагогічних і корекційно-розвивальних послуг у територіальних громадах, які є необхідними для дітей з особливими освітніми потребами та їх сімей, у тому числі внутрішньо переміщених.Окреслено коло проблемних питань, які потребують вирішення, зокрема, брак ресурсів, досвіду, розуміння основних переваг нової філософії освіти; створення адекватних умов для дітей з різними рівнями освітніх труднощів у навчанні (в тому числі для осіб з різних національних меншин та обдарованих).
Die "Waldzuweisung im Brixner Kreise"
Authors: Barbacetto Stefano
Published: October 2023

Die Entwicklung des Tiroler Forstrechts: Eine Untersuchung der Eigentumsübertragung an die politischen Gemeinden und Gemeindefraktionen im 19. Jahrhundert Mit der allerhöchsten Entschließung vom 6. Februar 1847 verzichtete Kaiser Ferdinand auf das umstrittene Forsthoheitsrecht, das seit dem Mittelalter jedes Privateigentum an Tiroler Wäldern ohne landesfürstliche Verleihung ausschloss. Das ärarische Eigentum wurde auf die Salinen- und Montanwaldungen beschränkt, die heute zu den Bundesforsten oder den Südtiroler Landesdomänen gehören. Im heutigen Osttiroler und Südtiroler Gebiet wurde diese grundlegende Reform 1847–1855 durch die Landgerichte und die "Waldzuweisungskommission" durchgeführt. Die Alttiroler Wälder wurden den Gemeinden übergeben; die bestehenden Nutzungsrechte durften weiter ausgeübt werden. Diese Forschungsarbeit ist ein Beitrag zur Erklärung des alten Tiroler Forstrechts und der rechtlichen Natur der vom Kaiser "beschenkten" Rechtssubjekte: der politischen Gemeinde und der Gemeindefraktion. Diese bildet die Voraussetzung um die späteren, verschiedenen Entwicklungen der Gemeindegutsfrage im Bundesland Tirol und im Land Südtirol zu verstehen.
Adaptation of business and consumers to modern challenges in Ukraine
Authors: Bila I , Zakrevska L , Kovalchuk I , Tkachenko O , Shevchenko O
Published: October 2023

Purpose. To study the process of adaptation and identify factors influencing the adaptability of business and consumers. To develop recommendations for increasing the level of adaptation of business and consumers and for ensuring the appropriate level of consumption by individuals. To develop a mathematical model of the current assessment of the level of adaptation. Methodology. General and special methods of cognition are used: abstract-logical method – to establish the complex nature of impact of large-scale challenges on the level of adaptation; induction and deduction – to establish the additive and multiplicative nature of threats; comparative analysis – to establish the fact that the adaptation process has a differentiated and unstable character and to identify factors influencing the adaptability of business and consumers. The generalization method is applied to propose the formation of a state Strategy for promoting the adaptation of business and consumers and ways of implementing it. The method of induction and deduction is used to establish the fact that the unstable nature of the adaptation capabilities of consumers requires the implementation of institutional measures, to propose these measures. Based on mathematical methods, a model of step-by-step adaptation and assessment of the level of adaptation was developed. Findings. Factors affecting the level of business and consumer adaptation were studied. It is established that adaptation processes have differentiated, uneven and unstable character and reasons for this are indicated. It is indicated that the impact of set threats can be additive and multiplicative in nature. It is indicated that effective adaptation of enterprises is possible only with the integration of efforts by management of enterprises and by state institutions. It is proposed to introduce the State Strategy for Facilitating the Adaptation of Businesses and Consumers. Originality. A mathematical model of the current assessment of the level of adaptation is developed. Practical value. The developed mathematical model makes it possible to assess compliance with the direction of adaptation and conduct operational planning of the enterprise in a more relevant manner.
¿Descolonizar o neo-colonizar los museos? Los objetos como rehenes y botín de guerra
Authors: Di Liscia María Silvia
Published: October 2023

La intervención en el debate obedece a reflexionar sobre la necesidad de la devolución a quienes reclaman legítimamente objetos de otras culturas y comunidades nacionales, existentes en museos coloniales y producto de conquistas y guerras anteriores. Se trata de capturas producidas con el carácter de botín de guerra y mantenerlos en colecciones ajenas a su origen, con el argumento patrimonial o técnico, es una forma de neo colonización museal
Mortality rate and factors associated with mortality of carbapenem-resistant Enterobacteriaceae infection
Authors: So-ngern Apichart , Osaithai Naphol , Meesing Atibordee , Chumpangern Worawat
Published: October 2023

Background: Carbapenem-resistant Enterobacteriaceae (CRE) is a serious pathogen with high mortality. Recognition of factors associated with mortality and treating these modifiable factors are crucial to reducing mortality.Objective: To determine the 30-day mortality and factors associated with a 30-day mortality of CRE infection.Methods: A retrospective cohort study was conducted between January 1, 2015, and December 31, 2019. All patients diagnosed with CRE infection aged ≥18 years were included. Multivariate logistic regression was used for evaluating the factors associated with 30-day mortality and presented as adjusted odds ratio (aOR) with 95% confidence interval (CI).Result: One hundred and ninety-four patients were enrolled. The 30-day mortality occurred in 75 patients (38.7%). The common antibiotic regimen was monotherapy and combination of carbapenem, colistin, amikacin, tigecycline, and fosfomycin. CRE isolates were susceptible to tigecycline (93.8%), colistin (91.8%), fosfomycin (89.2%), and amikacin (89.2%). The independent factors associated with 30-day mortality were an increasing simplified acute physiology (SAP) II score (aOR 1.11, 95% CI 1.05-1.16, p < 0.001), sepsis at time of CRE infection diagnosis (aOR 7.93, 95% CI 2.21-28.51, p = 0.002), pneumonia (aOR 4.48, 95% CI 1.61-12.44, p = 0.004), monotherapy (aOR 4.69, 95% CI 1.71-12.85, p = 0.003), and improper empiric antibiotic (aOR 5.13, 95% CI 1.83-14.40, p = 0.002).Conclusion: The overall 30-day mortality of CRE infection was high. The factors associated with mortality were an increasing SAP II score, sepsis at time of CRE infection diagnosis, pneumonia, monotherapy, and improper empiric antibiotic. The study suggested that proper empiric antibiotic and combination antibiotics might reduce mortality from CRE infection.
Comparing the Performance of Medical Students, ChatGPT-3.5 and ChatGPT-4 in Biostatistics Exam: Pros and Cons as an Education Assistant.
Authors: ASKER Ömer Faruk , ÖZGÜR Emrah Gökay , ERİÇ Alper , BEKİROĞLU Nural
Published: October 2023

Studies have shown that the level of knowledge in biostatistics among medical students is lower than expected. This situation calls for the need to implement new methods in biostatistics education. The aim of this study is to evaluate the feasibility of ChatGPT as an education assistant in biostatistics. ChatGPT is a natural language processing model developed by OpenAI. It provides human-like responses to questions asked by users and is utilized in various fields for gaining information. ChatGPT operates with the latest GPT-4 model, while the previous version, GPT-3.5, is still in use. In this study the biostatistics performance of 245 Marmara University School of Medicine students was compared to ChatGPT-3.5 and ChatGPT-4 using an exam covering basic biostatistics topics. According to findings, ChatGPT-3.5 achieved 80% success rate in the exam, while ChatGPT-4 achieved 100% success rate. In contrast, the students achieved 67.9% success rate. Furthermore, ChatGPT-3.5 only recorded 33% success rate in questions requiring mathematical calculations, while ChatGPT-4 achieved 100% success rate in these questions. In conclusion, ChatGPT is a potential education assistant in biostatistics. Its success has increased significantly in the current version compared to the previous one. Further studies will be needed as new versions are released.
Experimental Study on the Pull-Out Capacity of Blind Rivet Nuts (BRNs) Mounted on Cold-Formed Square Hollow Section Members with Different Wall Thickness
Authors: COSGUN Suleyman Istemihan
Published: October 2023

In this study, pull-out tests of blind rivet nuts (BRNs) mounted on cold-formed square hollow section (SHS) webs with 100×100 mm nominal cross-section dimensions and different wall thicknesses (2.0 to 5.0 mm) were performed, and the effect of different wall thicknesses and BRN thread sizes on the test results was experimentally investigated. M10 and M12 stainless steel BRNs were mounted on SHSs using a standard riveter tool, and the test elements were prepared for the experiment. Load–displacement curves and the final damage modes were obtained for each test specimen. The results show that the pull-out capacity depends on both the SHS wall thickness and rivet nut thread size. Although the pull-out capacity increased in both thread sizes with the increase in wall thickness parameters, the effect of thread size is negligible in the case of 2.5, 3.0, and 4.0 wall thickness. In addition, when a connection is created using a BRN, the design should consider the stripped thread strength in addition to the pull-out capacity.
IDENTIFIKASI SEKTOR UNGGULAN DALAM MENINGKATKAN EKONOMI DAERAH DI KABUPATEN BANYUMAS
Authors: Pangestika Maulida Dewi
Published: October 2023

Abstract.

Identification of leading sectors in banyumas regency is one of the means to develop economy according to its potential. This is opportunity for the region to employ natural resources. However, there is a decentralization policy  haven’t been able to improve economy. Its indicated by the high regional inequality even though the source of financing has been fully managed by the local government. This study purpose to determine the superior sector of banyumas regency. The study uses secondary data sources from the central statistics agency in the 2018-2022. The analysis used includes location quentiont (LQ), shift share (SS), and Tipology Klassen. The results showed that Banyumas regency had a shift in leading sectors with prime categories sectors including industrial processing, construction, information and communication. While, potential conditions including retail trade, agriculture.

Keyword: leading sector, gross domestic bruto, fiscal decentralization

Abstraksi.

Identifikasi sektor unggulan pada kabupaten banyumas merupakan salah satu upaya dalam mengembangkan ekonomi sesuai dengan potensi yang dimiliki. Hal tersebut menjadi peluang bagi wilayah dalam memanfaatkan sumber daya alam. Namun adanya kebijakan desentralisasi fiskal ternyata belum mampu memaksimalkan perekonomian. Hal ini ditunjukkan dengan tingginya ketimpangan wilayah walaupun sumber pendanaan sepenuhnya telah dikelola oleh pemerintah daerah. Penelitian ini bertujuan unuk mengetahui sektor unggulan kabupaten banyumas. Penelitian ini menggunakan sumber data sekunder dari badan pusat statistik pada rentan waktu tahun 2018-2022. Analisis yang digunakan antara lain Location Quentiont, Shift Share, dan tipologi klassen. Hasil penelitian didapat bahwa kabupaten banyumas memiliki pergeseran sektor unggulan dengan kategori prima atau perekonomian cepat antara lain industri pengolahan, konstruksi,dam informasi dan komunikasi, sedangkan kondisi potensial yaitu perdagangan besar dan eceran serta pertanian, pertenak, dan perikanan.

Kata kunci: sektor unggulan, produk domestik regional bruto, desentralisasi fiskal
RPP BERBASIS MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERDASARKAN PROSEDUR PENGEMBANGAN ADDIE
Authors: Emylda Kusuma Trisna Wati  , Nur Kuswanti  , Noer Afâ€™idah
Published: October 2023

Abstract: The effectiveness and achievement of learning objectives are determined by the educators. Educators must design lesson plans before learning activities take place. This study aims to develop lesson plans based on cooperative learning model type STAD, quality excretion system material based on the level of validity. This development uses ADDIE (analysis, design, development, application, and evaluation). However, due to constrained conditions during the Covid-19 epidemic, the implementation stage was not carried out. The data collection method used lesson plan validation sheet. The data were obtained through a validity test. The results of the validity test in the form of lesson plans developed are classified as valid with an average value of 4.5 so that they are suitable to be used in learning.

Keywords: Lesson Plans, Cooperative Learning, STAD

 

 

Abstrak: Efektifitas dan tercapainya tujuan pembelajaran ditentukan oleh pendidik. Pendidik harus merancang RPP sebelum kegiatan pembelajaran berlangsung. Penelitian ini bertujuan mengembangkan RPP berbasis model pembelajaran kooperatif Tipe STAD materi sistem ekskresi yang berkualitas berdasarkan tingkat kevalidan. Pengembangan ini menggunakan ADDIE (analisis, perancangan, pengembangan, penerapan, dan evaluasi). Akan tetapi, dikarenakan terkendalanya kondisi pandemi covid-19, tahap penerapan tidak dilakukan. Metode pengumpulan data menggunakan lembar validasi RPP. Perolehan data dilakukan uji validitas. Hasil uji validitas berupa RPP yang dikembangkan tergolong valid dengan nilai rata-rata 4,5 sehingga layak untuk digunakan dalam pembelajaran.

Kata kunci: RPP, Pembelajaran Kooperatif, STAD
PERBEDAAN HASIL BELAJAR GEOMETRI SISWA MENGGUNAKAN MODEL KOOPERATIF TIPE GROUP INVESTIGATION BERBANTUAN GEOGEBRA, MODEL KOOPERATIF TIPE GROUP INVESTIGATION, DAN MODEL DIRECT INSTRUCTION
Authors: Virginia Polii  , James U. L. Mangobi  , Derel F. Kaunang
Published: October 2023

This research was carried out at SMA Negeri 1 Dumoga in the second semester of the 2020/2021 academic year. The research method used is quasi-experimental. The research subjects were 23 students of class X MIA 1 who were taught using the Cooperative learning model of Group Investigation tipe, 23 students of class X MIA 2 who were taught using the Direct Instruction learning model, and 24 students of class X MIA 3 who were taught using the Geogebra-Asissted Group Investigation Cooperative learning model. The research instrument used was a test of learning outcomes in the form of posttest questions. Hypothesis testing shows the value of Fcount > Ftable which means H0 is rejected, thus it can be concluded that there is a significant difference in average learning outcomes. Furthermore, based on further testing with the BNT test, It was obtained: The learning outcomes of students that applied the Geogebra-Asissted Cooperative learning model were not significantly different from the class that applied the Group Investigation type of Cooperative learning model. The learning outcomes of students that applied the Geogebra-Asissted Cooperative learning model were significantly different from the class that applied the Direct Instruction model. The learning outcomes of students that applied the Group Investigation type of Cooperative learning model were significantly different from the class that applied the Direct Instruction learning model.Keywords: Geometry Learning Outcomes, Group Investigation, Direct Instruction, Geogebra
PENINGKATAN HASIL BELAJAR PESERTA DIDIK MATERI TEKS DEBAT MELALUI PEMBELAJARAN TIME TOKEN DI KELAS X MM 1 SMK NEGERI 1 PUNGGING
Authors: IM. SHOFIâ€™I
Published: October 2023

The purpose of this research is to know the results of the implementation of the time token learning method based on the implementation of the lesson plans that have been developed, and the activities during student learning and learning outcomes related to debate material. The research being conducted was classroom action research conducted in Class X MM 1 Semester 2 of the 2019/2020 Academic Year at SMK Negeri 1 Pungging involving 32 students. The results of the research that has been carried out explain that the application of the time token learning method is able to provide an increase in student learning outcomes. This is evidenced by the percentage value of student learning test results which was only 16.63% in the initial conditions, then in the first cycle it became 75% and increased to 93.37% in the second cycle. The lesson plan implementation section also experienced an average increase, namely the average score from 2.75 in the first cycle to 3.64 in the second cycle and the lesson plan implementation section received a score of 100% in both cycles. In the student activity section it is also shown that learning is student-centered, this can be seen from the increase in the percentage when implementing time token learning and discussions and there is a decrease in inappropriate/inappropriate behavior.
Sistem Informasi Pada Kantor Dinas Perdagangan Kota Palopo Berbasis Website
Authors: Hardiana Hardiana , Akrammunisa Akrammunisa
Published: October 2023

Penelitian ini bertujuan untuk merancang dan membangun sistem informasi pada kantor Dinas Perdagangan Kota Palopo berbasis website. Metode penelitian yang digunakan untuk merancang dan membangun dalam penelitian ini adalah Research and Development (RD) yang mengacu pada metode pengembangan waterfall. Tahapan penelitan dimulai dengan tahap analisis kebutuhan dengan melakukan pengumpulan data berupa observasi, wawancara, dan studi pustaka. Kemudian dilanjutkan dengan tahap desain sistem menggunakan UML (Unifed Modeling Language) dengan bantuan aplikasi Microsoft Visio 2016. Perancangan interface dibuat menggunakan aplikasi Balsamiq Mokcups. Pada tahap pembuatan sistem menggunakan bantuan bahasa pemrograman HTML dan PHP, serta Framework Bootstrap untuk membangun website. Penulisan kode program menggunakan aplikasi Sublime Text 3. Database yang digunakan MySQL dengan bantuan aplikasi XAMPP sebagai lokal server. Google Chrome digunakan untuk melihat tampilan interface website. Tahap pengujian dilakukan dengan teknik pengujian blackbox dan pengujian. Pengujian blackbox yang telah dilakukan dengan total jumlah menu 22, hasil dari pengujian ini menunjukkan bahwa semua fungsionalitas tombol dan menu website dapat berjalan dengan baik. Sedangkan untuk pengujian ahli mendapatkan jumlah rata-rata sebanyak 4,6, dimana angka tersebut masuk dalam kategori sangat baik. Hasil dari penelitian ini berupa sistem inforrmasi layanan pada kantor Dinas Perdagangan Kota Palopo Berbasis Website. Sistem telah diimplementasikan kedalam bentuk website yang sudah layak untuk digunakan.
Transcriptional regulatory network for neuron-glia interactions and its implication for DYT6 dystonia
Authors: Yellajoshyula Dhananjay
Published: October 2023

Advances in sequencing technologies have identified novel genes associated with inherited forms of dystonia, providing valuable insights into its genetic basis and revealing diverse genetic pathways and mechanisms involved in its pathophysiology. Since identifying genetic variation in the transcription factor coding THAP1 gene linked to isolated dystonia, numerous investigations have employed transcriptomic studies in DYT-THAP1 models to uncover pathogenic molecular mechanisms underlying dystonia. This review examines key findings from transcriptomic studies conducted on in vivo and in vitro DYT-THAP1 models, which demonstrate that the THAP1-regulated transcriptome is diverse and cell-specific, yet it is bound and co-regulated by a common set of proteins. Prominent among its functions, THAP1 and its co-regulatory network target molecular pathways critical for generating myelinating oligodendrocytes that ensheath axons and generate white matter in the central nervous system. Several lines of investigation have demonstrated the importance of myelination and oligodendrogenesis in motor function during development and in adults, emphasizing the non-cell autonomous contributions of glial cells to neural circuits involved in motor function. Further research on the role of myelin abnormalities in motor deficits in DYT6 models will enhance our understanding of axon-glia interactions in dystonia pathophysiology and provide potential therapeutic interventions targeting these pathways.
Insights into the reactivity and lithium plating mechanisms of ultra-thin metal oxide coatings for anode-free solid-state lithium metal batteries
Authors: Counihan Michael J. , Kim Taewoo , Pathak Rajesh , Zagorac Teodora , Yang Yingjie , Burns Meghan E. , Cabana Jordi , Klie Robert F. , Hanley Luke , Connell Justin G. , Mane Anil U. , Elam Jeffrey W. , Tepavcevic Sanja
Published: October 2023

Solid-state batteries (SSBs) in an “anode-free” cell format using lithium metal anodes are the best candidates for high energy density battery applications. However, low lithium metal Coulombic efficiency and charge loss due to solid electrolyte interphase (SEI) formation severely limit the cycle life of anode-free SSBs. Here, we explore ultra-thin (5–20 nm) Al2O3 and ZnO coatings deposited by atomic layer deposition (ALD) on copper electrodes for anode-free cells with a solid polymer electrolyte. Voltammetry shows that lithium inventory loss from SEI formation is reduced over 50% with Al2O3@Cu electrodes, but these electrodes experience orders of magnitude higher interface resistances than bare Cu and ZnO@Cu electrodes due to low ionic and electronic conductivities. The electrochemical differences are reflected in XPS, where Al2O3 undergoes a self-limiting lithiation reaction with Li0, while ZnO reacts completely with Li0 to form LiZn and Li2O. These chemical differences result in higher and lower lithium plating nucleation overpotentials for Al2O3 (up to 220 mV) and ZnO (down to 15 mV) coatings, respectively, relative to uncoated Cu electrodes (35 mV). ToF-SIMS reveals lithium plating underneath a LiyAlOx coating and through emergent defects and pinholes with Al2O3@Cu electrodes, while it plates exclusively on top of converted ZnO@Cu electrodes. SEM corroborates these mechanisms, showing sparse coverage of isolated Li clusters plated with Al2O3@Cu electrodes, while Cu and ZnO@Cu grow more dense and interconnected deposits. Despite both coatings improving different aspects of anode-free battery design, unmodified Cu electrodes show higher Coulombic efficiencies (∼77%) than Al2O3@Cu (up to 70%) and ZnO@Cu (up to 75%) electrodes. Increasing Al2O3 thickness decreases the practical current density compared to unmodified Cu (30 µA/cm2), but increasing ZnO thicknesses can double or triple this value. These (electro)chemical and morphological observations suggest two mechanisms: less-reactive metal oxides develop lithium ion conductivity through their structure to plate lithium underneath, while more-reactive metal oxides undergo full reduction and conversion with lithium plating above the coating. This fundamental research opens future work to leverage these mechanisms and explore other materials for high-efficiency anode-free SSBs.
Endothelial glycocalyx sensitivity to chemical and mechanical sub-endothelial substrate properties
Authors: Hamrangsekachaee Mohammad , Wen Ke , Yazdani Narges , Willits Rebecca K. , Bencherif Sidi A. , Ebong Eno E.
Published: October 2023

Glycocalyx (GCX) is a carbohydrate-rich structure that coats the surface of endothelial cells (ECs) and lines the blood vessel lumen. Mechanical perturbations in the vascular environment, such as blood vessel stiffness, can be transduced and sent to ECs through mechanosensors such as GCX. Adverse stiffness alters GCX-mediated mechanotransduction and leads to EC dysfunction and eventually atherosclerotic cardiovascular diseases. To understand GCX-regulated mechanotransduction events, an in vitro model emulating in vivo vessel conditions is needed. To this end, we investigated the impact of matrix chemical and mechanical properties on GCX expression via fabricating a tunable non-swelling matrix based on the collagen-derived polypeptide, gelatin. To study the effect of matrix composition, we conducted a comparative analysis of GCX expression using different concentrations (60–25,000 μg/mL) of gelatin and gelatin methacrylate (GelMA) in comparison to fibronectin (60 μg/mL), a standard coating material for GCX-related studies. Using immunocytochemistry analysis, we showed for the first time that different substrate compositions and concentrations altered the overall GCX expression on human umbilical vein ECs (HUVECs). Subsequently, GelMA hydrogels were fabricated with stiffnesses of 2.5 and 5 kPa, representing healthy vessel tissues, and 10 kPa, corresponding to diseased vessel tissues. Immunocytochemistry analysis showed that on hydrogels with different levels of stiffness, the GCX expression in HUVECs remained unchanged, while its major polysaccharide components exhibited dysregulation in distinct patterns. For example, there was a significant decrease in heparan sulfate expression on pathological substrates (10 kPa), while sialic acid expression increased with increased matrix stiffness. This study suggests the specific mechanisms through which GCX may influence ECs in modulating barrier function, immune cell adhesion, and mechanotransduction function under distinct chemical and mechanical conditions of both healthy and diseased substrates.
Microbial involvement in iodine cycle: mechanisms and potential applications
Authors: Duborská Eva , Vojtková Hana , Matulová Michaela , Šeda Martin , Matúš Peter
Published: October 2023

Stable iodine isotopes are essential for humans as they are necessary for producing thyroid gland hormones. However, there are hazardous radioactive iodine isotopes that are emitted into the environment through radioactive waste generated by nuclear power plants, nuclear weapon tests, and medical practice. Due to the biophilic character of iodine radionuclides and their enormous biomagnification potential, their elimination from contaminated environments is essential to prevent the spread of radioactive pollution in ecosystems. Since microorganisms play a vital role in controlling iodine cycling and fate in the environment, they also can be efficiently utilized in solving the issue of contamination spread. Thus, this paper summarizes all known on microbial processes that are involved in iodine transformation to highlight their prospects in remediation of the sites contaminated with radioactive iodine isotopes.
Mesenchymal stromal/stem cells and bronchopulmonary dysplasia
Authors: Zhang Shuqing , Mulder Cassidy , Riddle Suzette , Song Rui , Yue Dongmei
Published: October 2023

Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants, leading to chronic respiratory disease. There has been an improvement in perinatal care, but many infants still suffer from impaired branching morphogenesis, alveolarization, and pulmonary capillary formation, causing lung function impairments and BPD. There is an increased risk of respiratory infections, pulmonary hypertension, and neurodevelopmental delays in infants with BPD, all of which can lead to long-term morbidity and mortality. Unfortunately, treatment options for Bronchopulmonary dysplasia are limited. A growing body of evidence indicates that mesenchymal stromal/stem cells (MSCs) can treat various lung diseases in regenerative medicine. MSCs are multipotent cells that can differentiate into multiple cell types, including lung cells, and possess immunomodulatory, anti-inflammatory, antioxidative stress, and regenerative properties. MSCs are regulated by mitochondrial function, as well as oxidant stress responses. Maintaining mitochondrial homeostasis will likely be key for MSCs to stimulate proper lung development and regeneration in Bronchopulmonary dysplasia. In recent years, MSCs have demonstrated promising results in treating and preventing bronchopulmonary dysplasia. Studies have shown that MSC therapy can reduce inflammation, mitochondrial impairment, lung injury, and fibrosis. In light of this, MSCs have emerged as a potential therapeutic option for treating Bronchopulmonary dysplasia. The article explores the role of MSCs in lung development and disease, summarizes MSC therapy’s effectiveness in treating Bronchopulmonary dysplasia, and delves into the mechanisms behind this treatment.
Exercise training affects hemodynamics and exercise capacity in cases of heart failure with preserved ejection fraction: a non-randomized controlled trial in individuals aged 65–80 years
Authors: Sugita Yousuke , Ito Katsuhiko , Yoshioka Yui , Kudo Ayano , Arakawa Sota , Sakai Satoshi
Published: October 2023

Introduction

Exercise training is an established intervention method for improving exercise capacity and survival rates in patients with heart failure with preserved ejection fraction (HFpEF). However, most reports have focused on European and American patients, with limited data regarding the effects of exercise training on cardiac function, hemodynamics, and exercise capacity in East Asian patients. This study investigated the effects of exercise training on cardiac function, hemodynamics, and exercise capacity in Japanese patients aged 65–80 years with HFpEF.

Methods

This single-center, open-label, non-randomized, controlled trial prospectively enrolled 99 outpatients. Eligibility criteria for HFpEF patients were an HFA score ≥5 in addition to clinical symptoms of heart failure and left ventricular diastolic dysfunction. Exercise training in the intervention group consisted of aerobic exercise and strength training thrice weekly for 5 months. Patients in the control group continued the usual treatment for 5 months. Resting cardiac function was evaluated using echocardiography. Peak oxygen uptake (peakVO2), ventilatory equivalent (VE) vs. carbon dioxide output (VCO2) slope, peak cardiac output index, and arteriovenous oxygen difference were calculated using cardiopulmonary exercise testing combined with impedance cardiography.

Results

After 5 months of exercise training, remarkable interactions were observed, with peakVO2 as the primary outcome. Additionally, significant interactions were observed between hemodynamic indices and some echocardiographic parameters. The mean percentage change in peakVO2 from baseline was 8.3% in the intervention group. Fifteen study participants (30.1%) in the intervention group achieved a clinically meaningful change of 3.0 ml/min/kg (10% improvement) in peakVO2 from baseline. The group with 3.0 ml/min/kg or 10% improvement in peakVO2 from baseline had a considerably lower prevalence of diabetes mellitus and VE vs. VCO2 slope and considerably higher left atrial-global longitudinal strain values than the group without any notable improvements.

Conclusions

Although exercise training can help improve exercise intolerance in Japanese patients aged 65–80 years with HFpEF, its benefits are limited. Our results suggest that HFpEF, complicated by diabetes mellitus and decreased ventilatory efficiency during exercise, may require reconsideration of intervention strategies. This trial was registered with the University Hospital Medical Information Network, a trial registry in Japan (registration number: UMIN000045474).
Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus
Authors: Shaikh M. Guftar , Lucas-Herald Angela K. , Dastamani Antonia , Salomon Estebanez Maria , Senniappan Senthil , Abid Noina , Ahmad Sumera , Alexander Sophie , Avatapalle Bindu , Awan Neelam , Blair Hester , Boyle Roisin , Chesover Alexander , Cochrane Barbara , Craigie Ross , Cunjamalay Annaruby , Dearman Sarah , De Coppi Paolo , Erlandson-Parry Karen , Flanagan Sarah E. , Gilbert Clare , Gilligan Niamh , Hall Caroline , Houghton Jayne , Kapoor Ritika , McDevitt Helen , Mohamed Zainab , Morgan Kate , Nicholson Jacqueline , Nikiforovski Ana , O'Shea Elaine , Shah Pratik , Wilson Kirsty , Worth Chris , Worthington Sarah , Banerjee Indraneel
Published: October 2023

Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion. CHI is of heterogeneous aetiology with a significant genetic component and is often unresponsive to standard medical therapy options. The treatment of CHI can be multifaceted and complex, requiring multidisciplinary input. It is important to manage hypoglycaemia in CHI promptly as the risk of long-term neurodisability arising from neuroglycopaenia is high. The UK CHI consensus on the practice and management of CHI was developed to optimise and harmonise clinical management of patients in centres specialising in CHI as well as in non-specialist centres engaged in collaborative, networked models of care. Using current best practice and a consensus approach, it provides guidance and practical advice in the domains of diagnosis, clinical assessment and treatment to mitigate hypoglycaemia risk and improve long term outcomes for health and well-being.
Goldfish adiponectin: (I) molecular cloning, tissue distribution, recombinant protein expression, and novel function as a satiety factor in fish model
Authors: Zheng Yunhua , Ye Cheng , He Mulan , Ko Wendy K. W. , Chan Ying Wai , Wong Anderson O. L.
Published: October 2023

Adiponectin (AdipoQ) is an adipokine involved in glucose homeostasis and lipid metabolism. In mammals, its role in appetite control is highly controversial. To shed light on the comparative aspects of AdipoQ in lower vertebrates, goldfish was used as a model to study feeding regulation by AdipoQ in fish species. As a first step, goldfish AdipoQ was cloned and found to be ubiquitously expressed at the tissue level. Using sequence alignment, protein modeling, phylogenetic analysis and comparative synteny, goldfish AdipoQ was shown to be evolutionarily related to its fish counterparts and structurally comparable with AdipoQ in higher vertebrates. In our study, recombinant goldfish AdipoQ was expressed in E. coli, purified by IMAC, and confirmed to be bioactive via activation of AdipoQ receptors expressed in HepG2 cells. Feeding in goldfish revealed that plasma levels of AdipoQ and its transcript expression in the liver and brain areas involved in appetite control including the telencephalon, optic tectum, and hypothalamus could be elevated by food intake. In parallel studies, IP and ICV injection of recombinant goldfish AdipoQ in goldfish was effective in reducing foraging behaviors and food consumption. Meanwhile, transcript expression of orexigenic factors (NPY, AgRP, orexin, and apelin) was suppressed with parallel rises in anorexigenic factors (POMC, CART, CCK, and MCH) in the telencephalon, optic tectum and/or hypothalamus. In these brain areas, transcript signals for leptin receptor were upregulated with concurrent drops in the NPY receptor and ghrelin receptors. In the experiment with IP injection of AdipoQ, transcript expression of leptin was also elevated with a parallel drop in ghrelin mRNA in the liver. These findings suggest that AdipoQ can act as a novel satiety factor in goldfish. In this case, AdipoQ signals (both central and peripheral) can be induced by feeding and act within the brain to inhibit feeding behaviors and food intake via differential regulation of orexigenic/anorexigenic factors and their receptors. The feeding inhibition observed may also involve the hepatic action of AdipoQ by modulation of feeding regulators expressed in the liver.