bluuebunny/crossref_metadata_2025 huggingface dataset:
دراسة بعض أراء محمد أفندي حجازي الصوتية في باب مخارج الحروف في كتابه الهدية النبوية في شرح الجزرية
Authors: أيمن عبد الله احمد
Published: April 2023

هذا البحث يهدف إلى دراسة ومناقشة بعض أراء محمد أفندي حجازي في باب مخارج الحروف من كتابه المسمى (الهِدية النبوية في شرح الجزرية)، فسمي البحث بعنوان: (دراسة بعض أراء محمد أفندي حجازي الصوتية في باب مخارج الحروف في كتابه الهدية النبوية في شرح الجزرية)، وقد قسمت البحث على مبحثين: الأول عرَّفت به بمحمد أفندي حجازي وشيوخه ومؤلفاته ووفاته، أما المطلب الثاني فكان للدراسة.وجد الباحث في نهاية البحث بأنَّ لمحمد أفندي حجازي آراء ومذاهب اتفق في بعضها مع من سبقه وأخرى خالفهم فيها، ومنها ما انفرد به ولم أجده عند غيره، من ذلك استشهاده بحديث منسوب إلى النبي لإثبات صحة أن حروف العربية تسعة وعشرون، ولم يجد الباحث تخريجاً لما استشهد به في كتب الحديث، كما أنه نسب إلى المبرد والخليل أراء وهماً منه والصواب خلاف ما قاله، وله موافقات ومخالفات بين سيبويه وابن الجزري، ومن نتائج البحث نجد أنَّ لمحمد أفندي حجازي تقسيما خاصاً بالأسنان. وسوف لا أطيل على القارئ الكريم حيث يتطلب المقام الاختصار، إذ هناك تفصيلا ونتائج أخرى ذكرت في ثنايا البحث كلا في موضع، أسال الله التوفيق والسداد.
أثر استراتيجية المعرفة السابقة والمكتسبة (K.W.L) في تحصيل طالبات الصف الثاني المتوسط في مادة الرياضيات وتفكيرهن التأملي
Authors: فاتن حسام طه
Published: April 2023

هدفت دراسة البحث الحالي الى معرفة أثر استراتيجية المعرفة السابقة والمكتسبة (K.W.L) في تحصيل طالبات الصف الثاني المتوسط في مادة الرياضيات وتفكيرهن التأملي، حيث تكونت عينة البحث من (50) طالبة مقسمين الى مجموعتين، المجموعة الاولى (25) طالبة تمثل المجموعة التجريبية التي درست وفق استراتيجية (K.W.L) والمجموعة الثانية (25) طالبة ايضا وهي تمثل المجموعة الضابطة التي درست وفق الطريقة الاعتيادية. تم تنفيذ التجربة من خلال استخدام مستلزماتها والتي من اهمها الخطط الدراسية المعدة للمجموعتين التجريبية والضابطة وتطبيق الاختبار التحصيلي البعدي ومقياس للتفكير التأملي بعد التحقق من صدقهما وثباتهما. وبمعالجة البيانات احصائيا كانت النتائج كما يأتي:1. يوجد فرق ذو دلالة احصائية عند مستوى (0.05) وهذا الفرق لصالح المجموعة التجريبية التي درست وفق استراتيجية جدول التعلم (K.W.L).2. يوجد فرق ذو دلالة احصائية عند مستوى دلالة (0.05) بين متوسطي التفكير التأملي لطالبات المجموعة التجريبية اللواتي درسن وفق استراتيجية (K.W.L)، وطالبات المجموعة الضابطة اللواتي درسن وفق الطريقة الاعتيادية.
غبطة حضرتي شعرية المخاتلة الأجناسية ومتعة البحث عن المستور
Authors: محمد يونس صالح
Published: April 2023

تنحدر القصيدة العربية الحديثة من سلسلة إدراك تام للمحيط بفلسفة الشعر وحمولاته وما يجب أن ينطوي عليه من مجالات جديدة تحدد هُويتها وتطرز مناخها الخاص، ولعل قابلية الانفتاح على المجاور القولي والسمعي والبصري هي من خير أدوات المخاتلة ومتعة البحث عن المستور على الصعيد الفنّي والدلالي، ولم تكن دقة الخصوصيّة الشعريّة وما تلتف عليه من أصول جذرية بمنأى عن ثورة (الحديث)، وصولًا إلى قصيدة تثير لبسًا في مفاهيمها ومستوياتها وحدودها.
The Interface Between Reproductive Health and Reported Mental Health Issues: DASS-42
Authors: Debnath Paramita , Shekhar Chander
Published: April 2023

The paper is on the interface between reproductive health and reported mental health issues of women in Delhi, India. Here Reproductive health has been divided into three categories: reproductive, gynaecologic, and contraceptive morbidities. As these illnesses account for a significant component of the disease burden in women. Therefore, they might lead to mental health issue among them. The research objectives of this study are to explore relationship between the two issues exiting in women.
Data on mental health status was collected using the Hindi version of the Depression Anxiety Stress Scale (DASS-42), while demographic household and Parental & spousal characteristics and details related to reproductive health were collected via a questionnaire devised for the study.
Women's age and reporting of a major illness were associated with reproductive and mental health issues. Also, women with 2 or more menstrual complication were more likely to have stress, for 2 or more gynaecological complication women were found to have symptoms of anxiety and women who had 2 or more delivery complications had major symptoms of depression.
From the study we can conclude that the stress of specific life events such as miscarriage, abortion, and menopause affect female mental health from a biological and psychosocial standpoint with the potential for secondary mood and anxiety disorders.

Keywords: Reproductive issues, mental health, menstrual, gynaecological and delivery complications.
MICROPLASTICS AND NANOPLASTICS IN THE AQUATIC ENVIRONMENT: CONTAMINATION, DETERMINATION AND INTERACTION WITH OTHER CONTAMINANTS
Authors: Banegas Maria Elena Nolasco , Saboia Luana , Barros Yasmin , Lemos Viviane Agostinho da Silva , Oliveira André Henrrique Barbosa de , Vidal Carla Bastos , Cavalcante Rivelino Martins
Published: April 2023

Background: After more than half a century since the increase in the dumping of plastics in the oceans and other bodies of water, the damage caused by these products and their fractions has been verified. Its presence compromises the quality of the environment due to its prolonged permanence in the habitat and potential for the adsorption of substances and release of chemical compounds to the environment responsible for the durability of the plastic. Aims: This paper aims to gather information about the source, characterization, and interactions of micro- and nanoplastic in the environment and provide current material for those curious about this pollution. Methods: This review was conducted searching for papers on micro and nanoplastics on Science Direct, Springer, and Elsevier databases using keywords such as “microplastic”, “nanoplastic”, “sources”, “contamination”, “instruments”, “analysis,” and “ocean”. This review used only published works and comprise the last seven years of research on the topic from the date the review was initiated. The work is structured in the definition of micro and nanoplastics, main sources, levels of contamination, adsorption processes, and characterization techniques. Results: Degradation drives the main role in producing micro- and nanoplastic. Studies have reported interactions between microplastic and hydrophobic and hydrophilic compounds and demonstrated that microplastics can concentrate inorganic and organic compounds in several orders of magnitude, acting as vectors for co-pollutants in the environment. Discussion: Factors such as exposure time, pH, salinity, temperature, and adsorbate concentration directly affect MP-pollutant selection processes. The adsorption process might happen in presence of micro- and nanoplastic since organic pollutants have a high affinity with solid or particulate materials. Methodologies and quantification vary significantly among studies making it difficult to synthesize data. Conclusions: This study demonstrates that numerous techniques are being modified to characterize micro- and nanoparticles. However, standardizing analysis methodologies has proven challenging due to the nature of these particles and their nanometer-scale size.
Predicting Financial Failure using Altman’s Z-Score Model:Evidence from CommercialBanks in Pakistan
Authors: Muhammad Junaid Khawaja
Published: April 2023

This paper aims to explore the predictability of financial failure in commercialbanks in Pakistan using Altman Z-score Model. Predicting the early financial failure indicates the concerned parties to intervene and take appropriate corrective actions before the bank finally fails. To achieve these objectives, the Altman Z-score model and current ratio tests are applied to the commercialbanks in Pakistan based on their financial statements and the analysis of the financial ratios during the period from 2016 to 2021. Theresults of the study show that Altman’s Z-Score model and current ratio appropriately predict the financial distress of commercialbanks in Pakistan, especially during the last two years. The results show that there isrisk of financial failure inalmost half of the commercialbanks of Pakistan.
Comparison between the Diagnostic Performances of Rapid Diagnostic Test (RDT) using Advantage Malaria Card Pf/Pv Ag, Microscopy, and Polymerase Chain Reaction (PCR) in Malaria Suspected patients at the Merauke Regional General Hospital
Authors: Milka Betaubun Amarensi , Oetama Adiatmaja Christophorus , V. Butarbutar Trieva , Wardhani Puspa , Aryati Aryati
Published: April 2023

Malaria prevalence in Indonesia is still high, especially in eastern Indonesia, namely Papua, reaching a peak of 16%, for example, in Merauke. The diagnosis of Malaria is conducted according to the gold standard, using the microscopy method. However, it is still limited, raising the need for a Rapid Diagnostic Test (RDT) examination. This study aims to evaluate the diagnostic performances of Immunochromatography (ICT) based RDT (using Advantage Malaria Card Pf/Pv Ag), compared to the diagnostic performances of microscopy and Polymerase Chain Reaction (PCR).This cross-sectional observational study took all fever patients of outpatient and inpatient care at the Merauke Regional General Hospital (hereinafter referred to as RSUD Merauke) from June to July 2019 as the samples. The sample population included all malaria patients with positive microscopy results, and the control population included all non-malarial fever patients at RSUD Merauke. Each specimen underwent microscopy (thick and thin preparations), RDT, and Real-Time (RT)-PCR tests using a Rotor Gene-Q (Qiagen) with abTESTM malaria 5qPCR III reagent. The diagnostic performances of RDT were analyzed by calculating its sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV). The study was conducted on 105 samples, namely 55 malaria samples and 50 control samples, who underwent microscopy, RDT, and RT-PCR. RDT sensitivity to microscopy, P. vivax 100%, P. falciparum 89.5%; specificity of P. vivax 95.7%, P. falciparum 97.7%. RDT sensitivity to RT-PCR, P. vivax 53.5%, P. falciparum 48.6%; specificity of P. vivax 100%, P. falciparum 98.5%. The RDT p-value for microscopy and RT-PCR was p=0.000. RDT k-coefficient of microscopy, P. vivax 0.937, P. falciparum 0.871. RDT k-coefficient of PCR, P. vivax 0.427, P. falciparum 0.531. RDT is more sensitive to P. vivax than microscopy. RDT is more specific to P. vivax than RT-PCR. Further studies are suggested to discuss anti-malaria drug resistance and sequencing.
Pengaruh Serbuk Besi Dan Natrium Silika Serta Natrium Hidroksida Terhadap Beton
Authors: Randa Yosua Kevin Jordan , Phengkarsa Frans , Sandy Desi
Published: April 2023

Penggunan serbuk besi sebagai penganti sebagian dari pasir pada campuran beton merupakan Salah satu alternatif untuk mengurangi limbah serbuk besi yang dapat mencemarkan lingkungan. Penelitian ini menggunakan serbuk besi dan natrium silika serta natrium hidroksida pada campuran beton yang bertujuan untuk mengetahui pengaruh sifat mekanis beton yang dihasilkan. Dalam penelitian ini dilakukan serangkaian tahapan proses yang meliputi pengujian karakteriktik material lalu perencanaan komposisi campuran beton dengan mix design serta pembuatan benda uji berupa silinder dengan ukuran 15 cm x 30 cm sebanyak 48 benda uji dan balok dengan ukuran 60 cm x 15 cm x 15 cm sebanyak 12 benda uji kemudian dilakukan pengujian benda uji dengan umur beton yang telah ditentukan yaitu 7 hari, 21 hari, dan 28 hari. Dari hasil penelitian penggunaan serbuk besi dengan variasi 0%, 10%, 15%, 20% diperoleh nilai kuat tekan sebesar 25,146 MPa, 18,514 MPa, 17,505 MPa, dan 16,770 MPa, sedangkan pada nilai kuat tarik didapatkan hasil sebesar 2,642 MPa, 1,463 MPa, 1,415 MPa, 1,345 MPa dan pada nilai kuat lentur berturut-turut diperoleh hasil sebesar 2,642 MPa, 1,463 MPa, 1,415 MPa dan 1,345 MPa. Dari hasil diatas menunjukkan bahwa penggunaan serbuk besi dan natrium silika serta natrium hidroksida dapat menurunkan sifat mekanis beton.
Penggunaan Abu Marmer Dan Fly Ash Sebagai Pengganti Sebagian Semen Pada Beton Normal
Authors: Papendang George Andre , Tanijaya Jonie , Sanggaria Olan Jujun
Published: April 2023

Setiap tahunnya jumlah limbah terus menerus bertambah, salah satunya limbah abu marmer, jumlah limbah akan terus bertambah baik dalam industri konstruksi, ekstraktif, fasilitatif dan lainnya. Tujuan dari penelitian ini untuk mengetahui nilai kuat tekan, kuat tarik belah dan modulus elastisitas dengan penelitian yang dilakukan di Laboratorium Struktur dan Bahan Universitas Kristen Indonesia Paulus Makassar. Benda uji yang digunakan yaitu silinder dengan diameter 150mm dan tinggi 300mm. Hasil pengujian kuat tekan dengan penambahan abu marmer 0% dengan fly ash 10% mengalami peningkatan sebesar 4,930% dari kuat tekan rencana, juga pada penambahan abu marmer 8% dengan fly ash 10% mengalami peningkatan sebesar 1,533%. Namun, pada penambahan abu marmer 12% dengan fly ash 10%, terjadi penurunan sebesar 9,035% dari nilai kuat tekan rencana sebesar 25 MPa. Hasil pengujian kuat tarik belah (ft) didapatkan nilai kuat tarik belah sebesar 2,713 MPa, 2,642 MPa dan 2,477 MPa. Untuk hasil pengujian Modulus Elastisitas (E) didapatkan nilai dengan penambahan abu marmer 0% dengan fly ash 10%, abu marmer 8% dengan fly ash 10% dan abu marmer 12% dengan fly ash 10%, sebesar 7979,762 MPa, 7597,352 MPa dan 7451,366 MPa. dari hasil penelitian dapat disimpulkan bahwa penambahan fly ash dengan variasi 10% masih mampu meningkatkan nilai kuat tekan, kuat tarik belah dan modulus elastisitas. Namun untuk penambahan abu marmer lebih dari 8% dapat menurunkan nilai kuat tekan, kuat tarik belah dan modulus elastisitas.
Relato de caso de diagnóstico de encefalite por dengue
Authors: Benassuly Erick Matheus Moreira , Osório Paulo Victor Machado , Hurtado Thiago Almeida , Areal Adriana Ferreira Barros
Published: April 2023

INTRODUÇÃO: A dengue é uma arbovirose, cursando como uma doença febril autolimitada, mas que pode evoluir com graves complicações. A encefalite é uma complicação rara. No Distrito Federal, em 2019, foram notificados 53.967 casos suspeitos de dengue. Considerando tal endemia, o presente trabalho visa relatar um caso de encefalite por dengue. RELATO DE CASO: W.F.L, 38 anos, hipertenso, encaminhado para atendimento com quadro de rebaixamento do nível de consciência com crise convulsiva tônico clônica generalizada de aproximadamente 4 minutos de duração. Quatro dias antes da admissão apresentou febre, cefaleia, dor retro-orbitária, mialgia, artralgia e náuseas, evoluindo com confusão mental, agressividade e perda de funções cognitivas. Como conduta inicial, foram prescritos aciclovir e dexametasona. Fora realizada sorologia IgM para dengue (reagente) sendo confirmado o diagnóstico de encefalite por dengue, conforme critérios diagnósticos. Paciente evoluiu com melhora do nível neurológico, recebendo alta hospitalar. DISCUSSÃO: A encefalite é uma das possíveis complicações da infecção pelo vírus da dengue, cursando com alteração do nível de consciência, alteração do comportamento e confusão mental. Devem ser realizados punção de líquido cefalorraquidiano, ressonância magnética e sorologia, para definição do agente etiológico e diagnóstico diferencial. CONCLUSÃO: O vírus da dengue deve ser pensado como um importante diagnóstico etiológico para encefalite, principalmente em regiões endêmicas, como o Brasil. Líquor compatível, síndrome febril com alteração do nível e conteúdo de consciência dentro de um cenário de endemia de arbovirose deve sempre alertar para encefalite por dengue dentre um dos diagnósticos diferenciais.
Síndrome da deiscência do canal semicircular superior: relato de caso
Authors: Melo Ana Couto de , Tolentino Paula D`Avila Sampaio , Braga Débora Cristiane Rocha , Diniz Nathalia Lima , Amaral Gabriela Ramos do , Dahmer Giuliane da Silva , Viana Lucas Moura
Published: April 2023

INTRODUÇÃO: A síndrome da deiscência do canal semicircular superior (SDCSS) é rara e ocorre devido ao desgaste da camada óssea que recobre o canal semicircular superior. As principais manifestações são vertigem e nistagmo, que são desencadeados pela alteração de pressão intracraniana e exposição à ruídos intensos. RELATO DE CASO: Paciente G.L.M.P., 41 anos, sexo masculino, apresentou-se ao ambulatório queixando-se de dificuldade de compreensão das palavras e hipoacusia esquerda há seis meses. Relatava ainda zumbido bilateral. Negava vertigem ou desequilíbrio. Sem alterações otológicas ao exame físico. Sem relato familiar de disacusia e sem exposição a ruídos. Ao exame audiológico, os limiares estavam normais em orelha direita, com presença de disacusia condutiva leve à esquerda com gap aéreo-ósseo em 500 Hz e 1.000 Hz, apresentando reflexo estapediano, curva tipanométrica tipo A. A tomografia computadorizada (TC) evidenciou deiscência do canal semicircular superior bilateral. Afastado demais queixas de hipoacusia, estabeleceu-se o diagnóstico de SDCSS. O tratamento estabelecido na ocasião foi de orientações e acompanhamento semestral. CONCLUSÃO: O paciente apresenta manifestações clínicas e achados tomográficos da SDCSS, contudo, devido à grande variedade de sinais e sintomas esse diagnóstico diferencial nem sempre é cogitado. O tratamento, na maior parte dos casos, é de orientação e de conduta conservadora. Em casos mais raros, pode ser necessário a intervenção cirúrgica. Portanto, o conhecimento sobre essa patologia é relevante por impactar na qualidade de vida do paciente.
SPECTER FROM A FICTION: AN UNTOLD STORY OF A WOMAN, BY A WOMAN, POSSIBLY TO EVERYONE…
Authors: Devi M. Sarada , Shaik Shakila Bhanu , Rao Dr. Ayyagari Nageswara
Published: April 2023

The present paper focuses on the projection of Indian women of Eastern world fighting for their faith in fiction with special insight to Kavita Kane’s “The Fisher Queen’s Dynasty”- a story of not-so-great portrayed mythological woman character Mastyagandha- The Queen of Hastinapur. Kane depiction of Satyavathi is admirable as she is able to bring out concoction of beauty, ambition, vulnerable and sorrow in her character. Author exposes the raw ambition of character in discourse brings out Satyavathi character through the words “It is better to I use my ambition wisely. I would rather make use of it and get benefits from it, as I have done it to Rishi Parashar”. Kavita Kane is one of the notable Indian authors, who had created tremor with her characters inspired from Mythology. The inquisition of least praised characters of mythology especially women who were marginalized, prejudice, or misrepresented. Providing cathartic voice to these victimized women (as projected in her writings) of patriarchal traditions. All the characters of Kane punctured the patriarchal expression by raising the voices of these woman characters of mythology. Her books are a beautiful exploration of human contradictions. The fallout of these contradictions leads to notable disaster and it induces the reader to appreciate these tensions as there were no standard answers to solve them. Kavita Kane excels in this art of persuasion with her exquisite characterization and gripping narrative. The success of her six novels which are purely based on myth is a testimony for this. This paper delves into the excellence of Kane’s ability in representing the mythical characters in her modern fiction.
THE OPTIMIZATION OF PUMP TYPE HYDRAULIC PUMPING UNIT BY REDESIGNING WELL SB-02 AT PT SMD TAMPI FIELD
Authors: Andalucia Sefilra , Moh. Riza Zakaria  , Rendi Sahputra
Published: April 2023

Production is an activity to transport hydrocarbon fluids from the subsurface (reservoir) to the surface. To increase the productivity of a Hydraulic Pump Unit, it is necessary to pay attention to pump production capacity, stroke length, pumping speed. A decrease in pump production can be caused by a variety of factors. This study aims to evaluate the possibility of increasing production in the study well by redesigning the Hydraulic Pump Unit in order to achieve optimum volumetric efficiency in the SB-02 Well in the Lampi Field. In this study, the data processing method by evaluating the installed pump and calculating the evaluation of the installed pump then calculating the volumetric efficiency of the pump if the production of SB-02 Well has not reached the specified target, it is necessary to optimize it. Based on dynagraph analysis, it is known that there is damage in the pump, namely in the fluid pound, so that the pump can be optimized by changing the pump parameters. HPU pump optimization is making an IPR Curve using the Darcy Method, because the water cut is only 1%. The optimization method was doing to change the pump parameters, namely pump stroke speed (SPM) and pump stroke length (SL). To get the optimal combination of pump parameters is done by nodal analysis (Pump Intake Curve). The redesign of the HPU pump optimization method is to change the pump stroke speed from 10 SPM to 9 SPM, Fixed Stroke Length which is 80 inches. After optimization was carried out on the SB-02 Well, the result obtained was an increase in the volumetric efficiency of the installed pump. The volumetric efficiency of the previously installed pump was 58.25% to 75.45%, the increase in production flow rate (Qt) from SB-02 Well was 32.90 bfpd, with the previous flow rate of 217.10 bfpd rising to 250 bfpd.
Evaluation of potentially toxic metal biosorption kinetics Mn (II) in acai pit residues (Euterpe Oleracea Mart.)
Authors: Souza Áurea Catarine , Nascimento Jéssica , Oliveira Jorge Diniz
Published: April 2023

Contamination of ecosystems with industrial and population advances has caused numerous problems to the environment and human health, as inappropriate disposal of effluents contaminated by potentially toxic metals impairs soil and groundwater. A low-cost and efficient alternative for the removal of these metals is biosorption which can be performed through biosorbents such as the açai pit residue (Euterpe Oleracea Mart.). This work evaluates the reuse of acai pit waste in fresh form and as chemically activated charcoal with HCl in Mn (II) ions biosorption. The reuse of acai residue as Mn (II) ions biosorbent has shown good biosorption capabilities, and modified biomass performed better performance in a shorter contact time than fresh (186.72 mg kg-1 in 10 hours). The kinetic study according to PFO, PSO, ELOVICH, and intraparticle biomass diffusion models in fresh and chemically modified form has shown for both better adjustment to the pseudo-second-order model, indicating that the Mn (II) ion biosorption process occurs via chemiosorption.
Technological tools for project management in the digital transformation context
Authors: Gonçalves Marcelo , Penha Renato , Da Silva Luciano , Kniess Claudia , Bizzarias Flavio
Published: April 2023

This article aims to identify the technological tools described in patents that present the relationship between Project Management (PM) and Digital Transformation (DT). The research is characterized as exploratory, with a qualitative approach, and investigates patents in public access bases. The research was carried out in the databases of the office of the World Intellectual Property Organization (WIPO) and the European Patent Office (EPO), bringing a set of 45 patents that addressed technological tools together with the relationship between PM and DT. The results show a great concentration in the patent classification groups G (Physics) and H (electricity), with predominance in the G group. The results also show that, in the context of DT and PM, individuals and teams capable of working with digital technologies and tools are more willing in scenarios of technological automation, process rationalization, agility, cost reduction, and value creation. This research contributes to expanding the knowledge in the use of technological tools in patents in a DT and PM context. In addition, evidence demonstrates that patents require technological capabilities with competent individuals to use technological tools and innovations.
Promising Treatments for Duchenne Muscular Dystrophy: Restoring Dystrophin Protein Expression Using Nucleic Acid Therapeutics
Authors: Hu Guo , Chen Chen
Published: April 2023

Review
Promising Treatments for Duchenne Muscular Dystrophy: Restoring Dystrophin Protein Expression Using Nucleic Acid Therapeutics

Guo Hu  and Chen Chen *

Division of Cardiology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
* Correspondence: chenchen@tjh.tjmu.edu.cn; Tel. & Fax: 86-27-6937-8422
 
 
Received: 10 October 2022
Accepted: 4 November 2022
Published: 11 January 2023
 

Abstract: Duchenne muscular dystrophy is caused by inadequate generation of functional dystrophin protein. Traditional clinical treatments can only slightly mitigate the progression of the disease, but not completely stem or reverse the decline in muscle function. Therapies aimed at dystrophin recovery are currently under development, among which are exon skipping and stop codon readthrough therapies. They are now used in clinics, while gene addition therapies are in phase III clinical trials. Gene editing therapies have also been approved for the first clinical trial recently. This review will discuss these emerging therapies, clinical trials, and directions for future developments.
Assessing Good Practices in Construction Safety and Phasing Plans
Authors: Korkmaz Kasim
Published: April 2023

Construction Safety and Phase Planning (CSPP) is a crucial document to have an impact on normal airport operations for any airport construction project. The basic intent of every CSPP is to minimize risk and to ensure that airport operations are not hindered at the time of construction activities taking place on the site. It is important to have such documents readily planned and prepared before initiating any construction activity at the airport. However, the requirements for such documents vary significantly around the world. International Civil Aviation Organization (ICAO) helps to create a mutual understanding of aviation policy, framework, and guidance. There is a lack of data identifying the differences between ICAO and CSPP. This can be challenging in terms of participating in the overseas market for consultancies and engineering firms for the very first time. Eventually, to perform the best practice for CSPP development, a lot of practicing firms find it arduous as there is little data available on understanding the best practice. This paper provides data that discusses and questions the possibility of best practices for CSPP development within the current industry and is further bolstered by case studies, surveys, and other empirical research found in project management research. The paper also confers the key differences present in the current practicing CSPP developments and the requirements published in ICAO states.
Simulation of Time and Frequency Domain of Photosensitizers Effect During Light Transport through Tissue as Applied to Photodynamic Therapy using a Steady State Monte Carlo Method with Simulink
Authors: N Felix Wejeyan
Published: April 2023

Photodynamic therapy (PDT) is a treatment process that makes use of a non-ionizing light source targeted at specific section of cells (a tumor) in order to induce apoptosis, and eventually, the death of cells in such area. This is achieved using specific light sensitive photosensitizing (PS) agents (in the case of this research Metvix-Methyl Aminolevulinate (MAL)) used to saturate the treatment area for a recorded time period before irradiating with non-ionizing light source. This research was designed to observe the time and frequency domains as the PS signal decays during the PDT process. During the process, the PS agent degenerates and becomes less and less interactive with the light source. Using the Hop/drop/spin nomenclature, the source of the incident photon is simulated using A Gaussian White Noise (AGWN) on Simulink and the incident signal is allowed to attenuate through the target area while the time and frequency domain of the photosensitizer MAL is recorded as it decays. It is observed that the amplitude of the absorption coefficient of the PS agent dropped to almost 0 during a short sample time while the normalized frequency decays with a highly damped and irregular oscillatory pattern. The improvement in attenuation due to the presence of the PS agent degenerates sharply during the initial state of the treatment in order to ensure that the generation of singlet oxygen terminates just after treatment time.
Opera, Audio Technologies, and Audience Practices in the Late Nineteenth Century
Authors: Palazzetti Nicolo
Published: April 2023

This article analyzes several novels and short stories by Jules Verne devoted to opera, audio technologies, and audience practices. This portion of Verne’s output is particularly thought-provoking for the cultural history of recording technologies, technologically-influenced listening practices, audience behavior, and music fandom. As often in Verne, the exploration of art worlds is connected with the exploration of technological inventions, such as recording and broadcast technologies. This article focuses in particular on L’Île à hélice (1895) and Le Château des Carpathes (1892). These novels are linked to their wider cultural, social, and technological contexts as well as to recent theoretical frameworks developed in the field of opera studies, sound studies, media studies, fan studies, the cultural history of technology, and Verne studies. The aim of the article is to shed light on the genesis of the relation between operatic audiences and audio technologies through a survey of Jules Verne’s visionary and imaginative narratives.
A PROTEÇÃO JURÍDICA DOS GRUPOS MINORITÁRIOS E VULNERÁVEIS: A IMPORTÂNCIA DA FUNÇÃO CONTRAMAJORITÁRIA DO PODER JUDICIÁRIO
Authors: Soares Gabrielle Valeri , Bôas Regina Vera Villas
Published: April 2023

O estudo ora desenvolvido pretende centrar-se na exploração do vínculo existente entre a proteção jurídica de minorias e de grupos vulneráveis e a função contramajoritária exercida pelo Poder Judiciário, notadamente, mediante a diferenciação existente entre o ativismo judicial e o efetivo espaço de atuação do Poder Judiciário. Perquire, igualmente, a demonstração de que o Poder Judiciário é, também, um espaço de exercício da democracia, constatação esta que ganha especial relevo diante de determinadas figuras (amicus curiae) e de certos diplomas legais (Lei da Ação Civil Pública e Lei da Ação Popular). Destaca, oportunamente, as decisões do Supremo Tribunal Federal que trouxeram a possibilidade de interrupção da gravidez em casos de anencefalia do feto e do enquadramento da homofobia e da transfobia como tipo penal definido na Lei do Racismo. Em termos teóricos, os principais autores utilizados na construção da pesquisa são Hannah Arendt, John objetivos da presente pesquisa podem ser assim sumarizados: explorar as funções representativa e contramajoritária do Poder Judiciário, a importância da proteção efetiva de grupos minoritários e vulneráveis, a existência do vínculo existente entre o controle do Poder e a proteção retromencionada, bem como a possibilidade de o Poder Judiciário vir a ser enxergado como um lugar em que a democracia deva ser exercida. A justificativa à construção e elaboração da presente pesquisa está nos prementes e constantes debates sobre eventual postura ativista do Poder Judiciário e seu papel desempenhado em um Estado Democrático de Direito. A metodologia utilizada é de abordagem qualitativa, de natureza básica e apresenta procedimento bibliográfico, documental, histórico e observacional, além de possuir objetivo explicativo. Os resultados do estudo desenvolvido apontam a existência de uma imbricação entre um bom funcionamento da limitação do Poder e a defesa de grupos minoritários e vulneráveis, podendo o Poder Judiciário designar importante função na consecução e efetivação da democracia.
EDUCAÇÃO PARA TODOS: UMA FERRAMENTA PARA A EQUIDADE E REDUÇÃO DAS DESIGUALDADES SOCIAIS
Authors: Iadocicco Fernanda Neves , De Oliveira Oséias Santos
Published: April 2023

A democratização da educação é inegável para o desenvolvimento social em todas as áreas, o que contribui para a construção de uma sociedade participativa e mais justa para todos. Sob este prisma o presente artigo tem como propósito analisar o processo de democratização desenvolvido no Brasil, a partir dos propósitos da Educação Para Todos, e as implicações na diminuição da desigualdade educacional, resultando em uma ferramenta para a equidade e redução das desigualdades sociais. A pesquisa, de natureza qualitativa, estrutura-se em uma análise bibliográfica, a partir de enfoques teóricos discutidos por autores que pesquisam sobre o tema, e também em uma análise documental, na qual são objetos de exploração o Relatório de Monitoramento Global de Educação para Todos e o Censo Escolar da Educação Básica dos períodos estudados. A partir destes enfoques são analisados, além do contexto histórico, os índices educacionais brasileiros e a avaliação feita por organismos internacionais do desempenho brasileiro. O estudo revela que o Brasil não cumpriu quatro desses seis objetivos: educação e cuidados na primeira infância, habilidades para jovens e adultos, alfabetização de adultos e a qualidade da educação. Isso nos mostra como a educação no Brasil ainda está longe de promover a igualdade social.
Efektivitas Pelaksanaan Pengaggaran Dengan Indikator Sstandar Biaya Pada Pemerintahan Pusat Dan Pemerintah Daerah
Authors: Ednoer Elzami Haqie , Ardiansyah Sondy Akbar , Firmansyah Amrie
Published: April 2023

Penelitian ini bertujuan untuk mengulas efektivitas dari pemanfaatan standar biaya pada pemerintahan pusat dan daerah di Indonesia. Data penelitian berdasarkan data sekunder mengacu artikel jurnal terdahulu yang membahas implementasi standar biaya pada pemerintah pusat dan pemerintah daerah. Penelitian ini menggunakan 12 literatur terindeks Sinta dengan kata kunci efektivitas pelaksanaan penganggaran dengan standar biaya. Penelitian ini menyimpulkan bahwa secara umum pelaksanaan penganggaran dengan penetapan standar biaya belum mampu diterapkan secara optimal karena keterbatasan pemahaman pegawai terhadap peraturan yang berlaku, serta perbedaan persepsi pegawai dalam menindaklanjuti pelaksanaan penganggaran. Di sisi lain, pemanfaatan standar satuan biaya di suatu daerah sudah terlaksana dengan baik, sehingga kinerja pengelolaan anggaran dengan standar biaya mampu mendorong pelaksanaan efisiensi anggaran.
Review of Resilience Conceptual , Assessment and Intervention
Authors: Yang Zongsheng
Published: April 2023

Resilience is a crucial resource for promoting the development of both mental and physical health. Researchers have divided resilience into three main categories, namely qualitative definition, outcome definition, and process definition, depending on their perspective. Typically, resilience is evaluated using resilience scales and emotional scales, and interventions can be carried out through social movements, community education, school education, individual counseling, and group counseling. Protective factors in resilience facilitate effective coping with negative events and promote healthy physical and mental development. The aim of this study is to review the existing research on the concept, assessment, and intervention of resilience and to identify future research directions. These directions include clarifying the connotation and extension of the concept, constructing the assessment index system, exploring the mechanism of action, expanding the coverage groups and contents, combining the theory and empirical evidence related to resilience and mental health literacy, and conducting in-depth research to improve the overall health and well-being of the public.
TO STUDY THE DEVELOPMENT OF SMART ROAD FOR ECONOMICAL & SOCIAL GROWTH OF URBAN AREA
Authors: Sharma Amit Kumar
Published: April 2023

Govt. of India Plan to develop 100 smart cities in which Bhopal is one of the part of it. The Bhopal Smart City have 342 acres area which is well planned with smart roads and with many amenities in South and North TT Nagar Bhopal. The area is designed for different sectors as PSP, Commercial area, Residential area, Green land, etc. The land is divided in different zones; this is one of the big projects that is designed as a smart city for the social and economic growth for the public and private sector. The road is designed with full amenities accordingly for the different sectors. The smart road is designed which enhances the development of the entire area. The era we live in is often regarded as the era of smart technology. Smart is a very popular term today and means clever, intelligent, perceptive and receptive. As an acronym for Self- Monitoring Analysis and Reporting Technology, it can be understood in its broadest sense ifit describes the essential characteristics of the innovative technologies that shape today's society in everyday life. Thus, the advent of the Smart Age, the era of intelligent technology, has greatly shaped and changed many aspects of today's society compared to the past. In this panorama, several new issues are related to transport infrastructure systems and more importantly road transport. Road transport in the modern sense, in pre-World War II India, very few vehicles used gasoline or diesel as fuel and had internal combustion engines.
Detection of Deep Fake in Face Images Based Machine Learning
Authors: Sabah Abdul kareem Hanady , Mahdi Altaei Mohammed Sahib
Published: April 2023

Fake face images is a recent critical issue of artificial intelligent due to it has directly impacts on the social lives, and may be made to imply threats against privacy, fraud, and other issues. Currently, creating fake images has become relatively simple due to the powerful yet user-friendly mobile applications that navigate in the social media world and with the invention of the Generative Adversarial Network (GAN) that provides a good quality  images that might be difficult for humans to differentiate with their eyes and makes image and video manipulation simple to do, quickly spread and hard to detect, Therefor, image processing and artificial intelligence are crucial in solving such problems. That is why scientists must create technologies or algorithms to control and to avoid these various negative impacts by different detection approaches can be applied. The proposed approach is more robust than current methods when propose a model based on support vector machine as a classifiers to detect fake human faces created by machines. The first stages includes a preprocessing that start with changing images from RGB to YCbCr and then applying the gamma correction. finalize the results show that the extracted edges using Canny filter were useful for detecting fakes in face images. After that, applying two distinct methods of detection by utilizing "Support Vector Machine" with "Principal Component Analysis" and "Support Vector Machine" without "Principal Component Analysis" as a classifiers. The findings show that the highest accuracy gained is 96.8% when using the SVM with PCA while the accuracy obtained is 72.2% when using the SVM alone.
Localización y supervivencia empresarial de los emprendimientos del sector comercial de la Provincia de Los Ríos
Authors: Monge Garcia Marcelo Geovanny , Cobo Litardo Elsye Teresa
Published: April 2023

La localización geográfica empresarial es una decisión de tipo estratégico. dicha decisión dependerá algunos elementos que pueden beneficiar o perjudicar la actividad económica de la misma, con esto el objetivo de la presente investigación es estudiar la localización y los irregulares niveles de supervivencia empresarial de las empresas y emprendimientos del sector comercial tanto mayorista y minorista de la provincia de Los Ríos, dentro de su metodología se puede mencionar que el presente articulo tiene un enfoque mixto de investigación con un predominante cuantitativo, además, es de orden descriptivo correlacional, para la comprobación de hipótesis se utilizó el Test Log-Rank y Kaplan-Meier para las curvas de supervivencia, como principales resultados se puede destacar que localización incide en la supervivencia empresarial de las empresas y emprendimientos del sector comercio mayorista y minorista de la provincia de los Ríos, conjuntamente la probabilidad de supervivencia empresarial es del 55,80%, el promedio de vida empresarial es de 13,94 años con un límite inferior de 13,83 años y un límite superior de 14,04 años.
Review of Malaysian Medicinal Plants with Potential Anticancer Activity
Authors: Mat Jusoh Muhammad Ashraf Aiman , Aris Farizan , Mohd Jalil Mohd Taufiq , Ahmad Kamil Khairunnisa , Zakaria Nurul Aili
Published: April 2023

The global cancer incidence and its high mortality rate indicate limitations in its current treatment and chemotherapeutic strategies. This sparked a worldwide interest in the demand for chemical diversity in searching for therapeutic drugs derived from natural products. Natural products from medicinal plants, whether as pure compounds or crude extracts, offer inexhaustible sources of new drugs because of their unparalleled chemical diversity. This review aims to disseminate detailed information on the anticancer potential of Malaysian medicinal plants, focusing on the bioactive phytochemicals and mechanisms of action against cancer development in both in vitro and in vivo studies. A comprehensive search of PubMed, Google Scholar, Scopus, and ScienceDirect databases was conducted to find relevant articles on the anticancer activity of Malaysian medicinal plants. A total of hundred and twenty-two (122) articles on the anticancer activity of Malaysian medicinal plants was identified and reviewed. Eighty-five (85) plants (in vitro) and 16 plants (in vivo) have been identified to possess anticancer activity. The activity reported was attributed primarily to diverse chemical groups of naturally occurring phytochemicals such as flavonoids, phenolics, glycosides, quercetin, and gallic acid. Henceforth, the findings will hope to aid further research in understanding the underlaying mechanism and the efficiency of the isolation of the bioactive compounds.
Genetic Variability of Wild Populations of Invasive Redclaw Crayfish (Cherax quadricarinatus) von Martens 1868 Across Peninsular Malaysia
Authors: Mohd Dali Mohamad Zulkarnain , Mohd Nasir Muhammad Syafiq Aiman , Khaleel Aliyu Garba , Madiran Nor Ainsyafikah , Ismail Norshida , Kamarudin Ahmad Syazni
Published: April 2023

The redclaw crayfish had been listed as an invasive species in Malaysia following the various negative impacts displayed on both environment and economy. The species are largely culture in Malaysia for food, but unluckily escaped and expands to several waterbodies across the country. For effective control management of redclaw crayfish species, a total of 52 wild samples were collected from six locations in Peninsular Malaysia and analyzed using a 16S mitochondrial DNA to assess their genetic diversity and introduction history. Five haplotypes were detected associated with an overall low genetic diversity (Hd = 0.385, π = 0.00133). A single genetic structure was detected with a phylogenetic relationship showing two clusters related to the haplotypes from Australia and Papua New Guinea. The finding of this study provides the basic data that will aid the appropriate Malaysian authorities for both monitoring and management strategies of redclaw crayfish in Peninsular Malaysia.
Self-Care Activities by Patients with Chronic Cardiovascular Morbidities: Explanatory Sequential Facility-Based Mixed Method Study in West Bengal, India
Authors: Banerjee Anagha , Goswami Pramit , Mandal Sutapa , Taraphdar Pranita
Published: April 2023

Background: Chronic cardiovascular morbidities are major public health concern. The objective was to assess awareness and practice of selfcare activities among patients with chronic cardiovascular morbidity in Burdwan Medical College (BMC) and to explore constraints in selfcare practice.
Materials & Methods: A facility-based, explanatory sequential, mixed-method study was conducted in Cardiology super-specialty outpatient department of BMC, West Bengal. A calculated sample of 185 patients with chronic cardiovascular morbidity were selected randomly; interviewed with predesigned, pretested schedule (adapted from H-SCALE) for quantitative component. For qualitative component, eight study participants, selected purposively, were interviewed with In-depth-interview guide. Multivariable logistic regression was done to find out predictors of selfcare practice. Thematic inductive analysis was done to explore constraints.
Results: 73% study participants were aware about overall selfcare practices; 43.8% performed satisfactory overall selfcare practice. Below secondary level educational status [AOR:0.412, 95% CI (0.178-0.956)] and lower & lower-middle socioeconomic status [AOR:0.063, 95% CI (0.017-0.230)] were found to create negative influence on favourable self-care practice. Thematic analysis revealed false belief, lack of motivation, lack of proper knowledge, emotional disturbances and Covid-19 pandemic impact as major constraints in selfcare practice.
Conclusion: Selfcare awareness & practice both are low. Interventions are needed to ensure healthy lifestyle of patients.
The impact of digitalization on the banking sector: Evidence from fintech countries
Authors: Bousrih Jihen
Published: April 2023

Banking services are now branded and are provided in distinct ways. It has been proven that the development of new financial services and products substantially impacts bank performance. This paper investigates the effect of e-banking services on the performance of banks before the pandemic. The study looks at a sample of 24 nations, including leading fintech nations. Data from 2012 to 2019 was gathered from the World Development Indicators and the Bank for International Settlements (BIS) databases. The findings show a significant positive correlation between cashless payments and banks' ROA. The performance of a bank is significantly impacted by mobile subscribers. In fact, customers are willing to use mobile transactions in place of traditional bank accounts. Banks' ability to generate revenue from assets (in the form of credits) is consequently restricted, which has an impact on their ability to earn a profit. The research suggests a range of policy implications and policy interconnections between digital financial services, banking stability, and efficiency. The banking sector has become more digitalized after the recent pandemic. To date, there is very little literature that has focused on the effect of digitalization on the banking sector before the Covid-19 crisis. The current study contributes to the literature by providing an overview of the relationship between the banking industry and digitalization before the latest pandemic for some leading fintech countries. This research will contribute to later comparisons between the different situations of the banking sector pre- and post-pandemic.
De rafelranden van de vernietiging van algemene voorwaarden
Authors: Spanjaard J.H.M.
Published: April 2023

De rafelranden van de vernietiging van algemene voorwaarden

Er zijn vier uitzonderingen op het recht van vernietiging van algemene voorwaarden wegens het verzaken door de gebruiker van de op hem rustende informatieplicht uit hoofde van artikel 6:233 onder b BW. Het zijn er vier in getal: (1) de wederpartij is een grote wederpartij, (2) de wederpartij is een in het buitenland gevestigde professional, (3) de wederpartij gebruikt zelf dezelfde of nagenoeg dezelfde set algemene voorwaarden, en (4) de wederpartij komt naar maatstaven van redelijkheid en billijkheid geen beroep op vernietiging van de algemene voorwaarden toe. Deze vier uitzonderingen worden in het artikel besproken aan de had van in 2022 gewezen rechtspraak.