bluuebunny/crossref_metadata_2025 huggingface dataset:
Model Geographically Weighted Weibull Regression pada Indikator Pencemaran Air Biochemical Oxygen Demand di Daerah Aliran Sungai Mahakam
Authors: Rahmah Siti Mahmudatur , Suyitno Suyitno , Siringoringo Meiliyani
Published: November 2023

Geographically Weighted Weibull Regression (GWWR) Model is a Weibull regression model applied to spatial data. Estimation of the GWWR model is performed at every observation location using spatial weighting. The purpose of this study was to determine the GWWR model of water pollution indicator Biochemical Oxygen Demand (BOD) data and the factors that influence BOD in the Mahakam River. The estimating parameters method of the GWWR model was the Maximum Likelihood Estimation (MLE) and it’s estimator was obtained by Newton-Raphson Iterative method. Spatial weighting in parameter estimation was determined using the Adaptive Bisquare weighting function and bandwidth optimum was determined by using Generalized Cross-Validation (GCV) criteria. Based on the GWWR model parameters testing, the factors that influence BOD locally was nitrate concentrations, while the factors influence globally were temperature and nitrate concentration.
Peramalan Jumlah Kunjungan Wisatawan Mancanegara Ke Indonesia Menggunakan Autoregressive Integrated Moving Average (ARIMA)
Authors: Ramadhani Adelia , Wahyuningsih Sri , Siringoringo Meiliyani
Published: November 2023

Autoregressive Moving Average (ARIMA) is a general model that is often used in time series modeling. One application of ARIMA can be used on the data foreign tourist visits to Indonesia. The tourism sector is one of the priority sectors in Indonesia's economic development. One of the determining factors in the tourism sector is the number of foreign tourist visits. Therefore, forecasting the number of foreign tourist visits is very necessary. The purpose of this study was to obtain a model and forecast results for the number of foreign tourist visits from March 2020 to October 2021 using the ARIMA model. The results of the analysis showed that the ARIMA model (0,1,1) was the best model with a MAPE of 6.23%. The forecasting results with the best model showed that the highest number of foreign tourist visits is in Agustus 2021 and the lowest is in December 2020.
Model Geographically Weighted Weibull Regression Pada Indikator Pencemaran Air COD di Daerah Aliran Sungai Mahakam Kalimantan Timur
Authors: Primadigna Ullimaz Sam , Suyitno Suyitno , Siringoringo Meiliyani
Published: November 2023

The Geographically Weighted Weibull Regression (GWWR) model is a Weibull regression model applied to spatial data. Parameter estimation is carried out at each observation location using spatial weighting. This study aimed to determine the GWWR model on the Chemical Oxygen Demand (COD) water pollution indicator data and to obtain the factors that influence COD in the Mahakam watershed. The parameter estimation method was Maximum Likelihood Estimation (MLE). Spatial weighting in parameter estimation has been determined using the adaptive tricube weighting function and the criteria for determining the optimum bandwidth was Generalized Cross-Validation (GCV). The research sample was 20 location points of the Mahakam river determined by the Environmental Department of East Kalimantan Province. The results showed that the factors that influence COD locally was temperature, while the factors that influence globally were temperature, Total Suspended Solids (TSS), and Fecal Coli.
Pengelompokan Kabupaten/Kota Di Pulau Kalimantan Berdasarkan Indikator Indeks Pembangunan Manusia Tahun 2020 Menggunakan Optimasi K-Means Cluster Dengan Principle Component Analysis (PCA)
Authors: Anwar Khoiril , Goejantoro Rito , Prangga Surya
Published: November 2023

Data mining is a technique or process to obtain useful information from a large database. Based on its functionality, one of the tasks of data mining is to group data. Cluster analysis is an analysis that aims to group objects based on the information found in the data. One of the cluster analysis methods is the K-Means cluster method, which is a non-hierarchical grouping method by dividing the data set into a number of groups that do not overlap between one group and another. This study aims to classify districts/cities on the island of Kalimantan based on indicators of the human development index and obtain the sillhoutte coefficient value from the optimal cluster analysis using the K-Means algorithm on principle component analysis. The data used is the 2020 human development index data in districts / cities on the island of Kalimantan and used 8 variables from the human development index indicator. The results of the optimal cluster formed in the grouping of regencies/cities on the island of Kalimantan using the K-Means cluster method on the principle component analysis are 4 clusters. Cluster 1 has 20 regencies/cities, cluster 2 has 3 regencies/cities, cluster 3 has 26 regencies/cities and cluster 4 has 7 regencies/cities. The sillhoutte coefficient value for data validation from district/city clustering on the island of Kalimantan using the K-Means cluster method on principle component analysis produces 4 clusters of 0.540 which states that the cluster structure formed in this grouping is a medium structure.
Optimasi Algoritma Naïve Bayes Menggunakan Algoritma Genetika Untuk Memprediksi Kelulusan
Authors: Feronica Elisa , Nasution Yuki Novia , Purnamasari Ika
Published: November 2023

The Naïve Bayes algorithm is classification method that uses the principle of probability to create predictive models. Naïve Bayes is based on the assumption that all its attributes are independent which can be optimized by genetic algorithms. Genetic algorithm is an optimization technique which works by imitating the process of evaluating and changing the genetic structure of living creatures. In this study, the Naive Bayes algorithm was optimized using by genetic algorithm to predict student graduation with attributes, namely gender, regional origin, admission path and employment status. The data used is the students of the Mathematics Department, Faculty of Mathematics and Natural Sciences, Mulawarman University who graduated in March 2018 to December 2020. The results of this study indicate the accuracy value generated by Naïve Bayes of 50% increased by 16,67% after the attributes were optimized by using the genetic algorithm to 66,67% with 3 selected attributes, namely regional origin, admission path and employment status
A Data Streaming Architecture for Air Quality Monitoring in Smart Cities
Authors: Miletić Aleksa , Lukovac Petar , Naumović Tamara , Stojanović Danijela , Labus Aleksandra
Published: November 2023

This paper aims to present a modeling approach for the seamless data streaming process from smart IoT systems to Apache Kafka, leveraging the MQTT protocol. The paper begins by discussing the concept of real-time data streaming, emphasizing the need to transfer data from IoT/edge devices and sensors to Apache Kafka in a timely manner. The second part consists of a literature overview that shows the analysis and systematization of different types of architectures in the broad sense of crowdsensing, followed by specific architectures regarding edge and cloud computing. The methodology section will propose an infrastructure and data streaming architecture for smart environment services, such as air quality monitoring. Lastly, a discussion about results and future development will be shown in the last two sections. The proposed integration approach offers several advantages, including efficient and scalable data streaming, real-time analytics, and enhanced data processing capabilities. Keywords: real-time data streaming, smart healthcare, Apache Kafka, data integration, stream processing
Retrospective Analysis of Fresh Single Blastocyst Transfer versus Two Cleavage-Stage Fresh Day-3 Embryo Transfer with High-Quality Embryos during Gonadotropin-Releasing Hormone Antagonist Cycles in High Responders
Authors: Xing Weijie , Ou Jianping , Yuan Feilv , Lin Xiaoqi , Zhang Yuan , Xia Tingting
Published: November 2023

Background: High responders are characterized by a large number of retrieved oocytes and/or a high level of estradiol on the day of administration of human chorionic gonadotropin. There is controversy in the literature regarding live birth rates from fresh day-5 single blastocyst transfer (day-5 SBT) compared to cleavage-stage fresh day-3 embryo transfer (day-3 ET) in high responders. The aim of this study was therefore to compare reproductive outcomes between day-5 SBT and day-3 ET using high-quality embryos and gonadotropin-releasing hormone (GnRH) antagonist protocols in high responders undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods: This was a single-center retrospective study of 282 high responders who underwent fresh day-5 SBT (day-5 SBT group, n = 142) or two cleavage-stage fresh day-3 embryo transfer (day-3 ET group, n = 140) between 2015 and 2019. Results: No significant differences were observed between the day-5 SBT and day-3 ET groups in terms of clinical pregnancy rate (51.41% vs. 59.29%, p = 0.183) or live birth rate (41.55% vs. 52.86%, p = 0.057). The incidence of multiple pregnancy (1.37% vs. 36.14%) and of low birth weight (5.00% vs. 32.26%) were significantly less frequent in the day-5 SBT group than in the day-3 ET group (p < 0.001 and p < 0.001, respectively). Conclusions: SBT may be the preferred choice for high-quality embryos in high responders undergoing IVF/ICSI during GnRH antagonist cycles with fresh embryo transfers. This is due to the lower incidence of obstetric complications compared to day-3 ET, although the clinical outcomes for the two groups are comparable.
Objective Measurement of Blood Loss following Vaginal Delivery in a UK Hospital
Authors: Devall Adam J. , Easter Christina L. , Price Malcolm J. , Islam Md Asiful , Coomarasamy Arri
Published: November 2023

Background: Postpartum haemorrhage (PPH) is the leading cause of maternal morbidity and mortality worldwide. The reported incidence of PPH varies globally, which is often due to the use of subjective visual estimation of blood loss. The aim of this study was to measure the rate of PPH and severe PPH at a UK hospital using objective measurement of blood loss. Methods: Blood loss after vaginal birth was objectively measured in 2009 women at Birmingham Women’s Hospital, UK using a blood collection drape. Results: The postpartum haemorrhage rate, defined as blood loss of 500 mL or more, was 22.2%. The severe PPH rate, defined as blood loss of 1000 mL or more, was 5.3%. Conclusions: The objective measurement of blood loss following vaginal birth is necessary for the accurate calculation of PPH rates.
Effect of Mifepristone Preconditioning on Stress Response and Sex Hormone Levels after Combined Laparoscopic Treatment for Cesarean Scar Pregnancy: A Prospective Randomized Trial
Authors: Chen Yan , Peng LiXiu , Shou Quan , Song Hong , Wang Qian
Published: November 2023

Background: This study aimed to explore the effect of mifepristone pretreatment on stress response and sex hormone levels after combined laparoscopic treatment for cesarean scar pregnancy. Methods: We conducted a prospective, randomized, controlled study from January 2020 to September 2022. A total of 98 pregnant women with cesarean scar pregnancy were included and divided into two groups by the random number table method. The control group received hysteroscopy combined with laparoscopy treatment, and the observation group received mifepristone pretreatment before hysteroscopy, combined with laparoscopy treatment. The surgical efficacy, surgical indices, menstrual recovery time, postoperative residual muscle layer, and scar morphology were observed and evaluated. The ovarian hemodynamic indices, stress indices, and sex hormone levels were measured, and the incidence of complications such as postoperative infection and liver function impairment was calculated. Results: There was no significant difference in the surgical success rate between the two groups (97.96% vs 95.92%), as well as the thickness and proportion of residual muscle layer, the width, length, and depth of scars, and the incidence of postoperative complications (p > 0.05). Combined mifepristone pretreatment reduced intraoperative bleeding, shortened the average time for beta human chorionic gonadotropin (β-hCG) to fall to negative (20.5 days, p < 0.05) and vaginal bleeding (19.8 days, p < 0.05), lowered Vmax (49.8 cm/s, p < 0.05), and elevated resistance index (RI) (0.7, p < 0.05) and pulsatility index (PI) (2.5, p < 0.05). Moreover, combined mifepristone pretreatment reduced C-reactive protein (CRP: 8.1 mg/L, p < 0.05), cortisol (COR: 21.7 mg/L, p < 0.05), adrenocorticotropic hormone (ACTH: 40.2 ng/L, p < 0.05), as well as progesterone (P: 10.2 mmol/L, p < 0.05), luteinizing hormone (LH: 13.2 µg/L, p < 0.05), and follicle-stimulating hormone (FSH: 14.8 µg/L, p < 0.05). Combined mifepristone pretreatment promoted the recovery of menstruation (25 days, p < 0.05). Conclusion: Mifepristone pretreatment can promote postoperative recovery, reduce postoperative stress response, improve hemodynamics, regulate sex hormone levels, and promote the early recovery of menstruation in patients with cesarean scar pregnancy. Clinical Trial Registration: The study was registered at Chinese Clinical Trial Registry (https://www.chictr.org.cn), registration number: ChiCTR1800015514.
Optimal Fasting Insulin Cutoff Value to Predict Clinical and/or Biochemical Hyperandrogenism in Korean Women with Polycystic Ovary Syndrome
Authors: Lee Seula , An Hyeonjun , Rhee Soojin , Chun Sungwook
Published: November 2023

Background: Insulin resistance and compensatory hyperinsulinemia play a critical role in the development of hyperandrogenism (HA) in polycystic ovary syndrome (PCOS) patients. To the best of our knowledge, however, few studies have determined the optimal fasting insulin cutoff value to predict HA in PCOS patients. Through this study, we aimed to investigate the optimal cutoff values for insulin and homeostatic model assessment for insulin resistance (HOMA-IR) to predict HA in women with PCOS. Methods: One hundred forty-eight women whose menarche occurred over eight years ago and were newly diagnosed with PCOS with irregular menstrual cycles (IM) and polycystic ovaries (PCO) using ultrasound after ruling out other etiologies were enrolled in this study. In this study, participants were categorized into two groups: those with clinical or biochemical HA (the IM/PCO/HA group) and those without HA (the IM/PCO group). To assess the relationship between androgen levels, including total testosterone (TT) and free testosterone (FT), and fasting glucose and insulin levels and HOMA-IR values, we performed correlation analysis using Spearman’s rank correlation coefficient. We used receiver operating characteristic (ROC) analysis to identify the optimal cutoff values for fasting insulin and HOMA-IR to predict HA in PCOS patients. Results: Fasting glucose and insulin levels and HOMA-IR values were significantly different between the IM/PCO/HA and IM/PCO groups. TT and FT levels exhibited significant correlations with fasting glucose and insulin levels and HOMA-IR values. The ROC analysis identified the most suitable fasting insulin cutoff value of 9.85 µU/mL with an area under the ROC curve (AUC) of 0.817 (60.7% sensitivity and 91.3% specificity) for predicting HA in women with PCOS. The ROC analysis also showed a HOMA-IR value of 2.22 as the optimal cutoff value for predicting HA (AUC, 0.820; 60.7% sensitivity, and 92.4% specificity). Conclusions: Our results support the classical concept that hyperinsulinemia contributes to HA in PCOS patients. Women with PCOS with fasting insulin levels of 9.85 µU/mL or higher (approximately ≥10 µU/mL) are strongly suspected to have HA.
Protective Effect of Ursodeoxycholic Acid in Experimental Endometriosis Induced Rat Model
Authors: Seven Ali , Kucur Suna Kabil , Erkayiran Uğurkan , Deger Ayşe Nur
Published: November 2023

Background: Considering the presence of an inflammatory process in the pathogenesis of endometriosis, anti-inflammatory agents could be an alternative option. The study aimed to elucidate the curative efficacy of Ursodeoxycholic acid (UDCA) on the experimental rat model of endometriosis. Methods: This experimental research included a total of 60 mature female Wistar albino rats (250 ± 50 g) with no pregnancy. They were grouped as Standard (n: 20), Laparoscopic Pretreatment (n: 10), Laparoscopic Posttreatment (Sham) (n: 10), UDCA-Pretreatment (n: 10) and UDCA-Posttreatment (n: 10). Transforming growth factor β1 (TGF-β1), matrix metallo-proteinases-2 (MMP-2), Tissue inhibitor of metalloproteinase-1 (TIMP-1), Tumor necrosis factor-α (TNF-α) were analyzed. Results: In the UDCA post-treatment group, endometriotic focal volume (43.3 ± 24.04 mm3) was lower than the pre-treatment values (165.7 ± 21.7 mm3) (p = 0.005). There was no significant change UDCA group before and after the treatment in terms of MMP-2, TGF-β1, TIMP-1 and TNF-α levels (p > 0.05). Comparing the posttreatment values of the Sham srugery group and the UDCA group, while the endometriotic focal volume was 251 ± 51 mm3 in the Sham group, it decreased to 43.3 ± 24 mm3 in the UDCA (p < 0.0001). Histological scoring decreased from 2.6 ± 0.51 to 1 ± 0.81 after the treatment (p = 0.001). Conclusions: The pre-treatment laparotomy group exhibited elevated TNF-α levels, indicating an inflammatory response. UDCA treatment reduced endometriotic focal volume and histological scoring, indicating a potential therapeutic benefit.
Association between Plasma Protein C Activity and Adverse Pregnancy Outcome in Pregnant Women: A Retrospective Cohort Study
Authors: Wang Yunxia , Wang Xiaoli , Xu Jian , Zhang Xiaojing , Wang Shan
Published: November 2023

Background: To assess the variations in protein C (PC) activity throughout pregnancy and investigate potential correlations between plasma PC activities and adverse pregnancy outcomes. Methods: A retrospective cohort study was conducted among 1511 women who underwent PC activity testing at a hospital in China from June 2011 to August 2021. t-test, Kruskal Wallis, Fisher’s exact test, logistic regression and receiver operator characteristic (ROC) analysis were used for analysis of data. Results: The PC activity demonstrated a significant increase during the second trimester of pregnancy. The PC activity was found to be lower in pregnant women with a history of thrombosis (median, 95.70% [interquartile range (IQR), 85.50–114.60%]) as compared to those without (median, 109.00% [IQR, 95.00–124.60%], p = 0.008) or with current thrombosis (median, 101.10% [IQR, 85.30–117.00%]) compared to those without such events (median, 109.00% [IQR, 95.00–124.78%], p = 0.013). History of thrombosis was the independent risk factor of current thrombosis during pregnancy (odd ratio (OR) 260.57; 95% confidence interval (95% CI), 76.751–884.689; p < 0.001). The PC activity of 125 cases of threatened abortion was significantly lower than that of asymptomatic women (median, 100.80% [IQR, 91.30–113.15%] vs median, 110.00% [IQR, 95.65–125.00%], p < 0.001). Multivariate analysis showed that the low PC activity (OR 0.985; 95% CI, 0.976–0.994, p = 0.001), gestational age (OR 0.960; 95% CI, 0.946–0.975; p < 0.001) and hypothyroidism (OR 1.888; 95% CI, 1.054–3.381; p < 0.05) were risk factors for threatened abortion. There was no difference in PC activity between fetal loss, hypertensive disorder complicating pregnancy (HDCP), fetal growth restriction (FGR), oligohydramnios, placental abruption and those without. Conclusions: Women with a history of thrombosis and decreased PC activity are risk factors for thrombosis and threatened abortion during pregnancy, respectively. However, no significant correlation was observed between PC activity and fetal loss, HDCP, FGR, oligohydramnios or placental abruption.
PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage
Authors: Xiong Xiao-Yi , Liang Yan-Jing , Zhang Xin-Xiao , Yang Su-Hao , Zhong Zhan-Qiong , Liu Shu-Qing , Sun Jia-Yi , Tang Yong , Yu Shu-Guang
Published: November 2023

Background: The purpose of this study was to investigate the potential involvement of pyruvate kinase M2 (PKM2), an enzyme acting as a rate-limiting enzyme in the final phase of glycolysis, in the regulation of glial activation and brain damage of intracerebral hemorrhage (ICH). Methods: Western blotting and immunofluorescence were performed to investigate PKM2 expression, terminal deoxynucleotidyl transferase deoxyurinary triphosphate (dUTP) nick end labeling staining, hematoxylin and eosin staining, and behavioral tests were employed to evaluate the brain damage of ICH mice, and RNA-seq and bioinformatic analyses were performed to detect gene expression changes in ICH mice treated with TEPP-46. Results: Increased PKM2 levels in perihematomal brain tissue were found starting from 3 days following ICH and peaked at 5 and 7 days post ICH. The increased expression of PKM2 was mainly co-localized with glial fibrillary acidic protein (GFAP)+ astrocytes and ionized calcium binding adaptor molecule-1 (IBA-1)+ microglia. Furthermore, we observed a notable increase in the nuclear translocation of PKM2 in glial cells following ICH. TEPP-46 treatment significantly reduced PKM2 nuclear translocation, and effectively attenuated glial activation and brain injury, and improved functional recovery of mice with ICH. RNA-seq data indicated that 91.1% (205/225) of differentially expressed genes (DEGs) were down-regulated in the TEPP-46 treated groups compared with the vehicle-treated groups in ICH brains. Furthermore, bioinformatic analyses revealed that these down-regulated DEGs were involved in a variety of biological processes, including autophagy and metabolic processes. In addition, the majority of these downregulated DEGs had a primary high expression in neurons, with subsequent expression seen in endothelial cells, microglia, and astrocytes. Conclusions: These results indicate that increased PKM2 nuclear translocation promotes the activation of glial cells after ICH, hence aggravating ICH-induced brain damage, and aggravates the brain injury induced by ICH. This highlights a potential therapeutic target for inhibiting glial activation to attenuate brain injury after ICH.
Review of Techniques for Protecting Side Branch from Occlusion during Provisional Stenting in Coronary Bifurcation Lesions
Authors: Li Dongdong , Dai Huimiao , Gao Chuncheng , Liu Hao , Yang Aili , Guo Wangang
Published: November 2023

Coronary bifurcation lesions remain one of the most challenging lesions for cardiology interventionists. The provisional stenting strategy has been regarded as the first option for most of these lesions. However, the main complication of this technique is side branch (SB) occlusion, which could lead to a peri-procedural myocardial infarction or even death. Various studies have focused on addressing this issue, but there are no definitive guidelines in the literature to treat these lesions. There isn’t enough clinical evidence from randomized controlled trial or two-arm cohort studies to illustrate which techniques provide the best outcomes. In this review, we summarize the mechanisms, independent predictors and predictive models of SB occlusion, and review seventeen techniques involving SB protection and occlusion rescue. Every technique was evaluated according to related bench tests, clinical studies and our own clinical experiences. The aim of this review is to provide interventionists with new insights for the treatment of coronary bifurcation lesions.
Vitamin D on Cardiac Function in Heart Failure: A Systematic Review and Meta-Analysis of 10 RCTs
Authors: Chen Xuemeng , Zhao Wenli , Zhao Yan , Ma Jingchao , Bu Huaien , Zhao Ye
Published: November 2023

Background: Systematic evaluation of the effects of vitamin D supplementation in heart failure (HF) patients. Methods: Searches were conducted on National Library of Medicine, Web of Science, Cochrane Library, Google Scholar, China National Knowledge Infrastructure, and WANFANG databases. We analyzed data by using Review Manager 5.4 software. All are from the earliest records to March 2023. Outcome indicators analyzed the left ventricular ejection fraction (LVEF), the left ventricular end-diastolic internal diameter (LVEDD), the B-type brain natriuretic peptide (BNP) level and the 25-hydroxy vitamin D (25(OH)D) level. Results: Ten studies with 1099 patients were included. LVEF (mean difference (MD) = 0.74, 95% CI: –0.29 to 1.76, p = 0.41), LVEDD (MD = –0.59, 95% CI: –1.83 to 0.66, p = 0.25), BNP (MD = –0.08, 95% CI: –0.24 to 0.08, p = 0.34), 25(OH)D (MD = 0.41, 95% CI: –0.28 to 1.11, p = 0.25) are not statistically significant. And there is no heterogeneity in the results of LVEF, LVEDD and BNP indicators. Conclusions: Vitamin D supplementation may not be helpful in the clinical management of patients with HF.
Rate, Timing, and Duration of Unplanned Readmissions Due to Cardiovascular Diseases among Hospitalized Patients with Cancer in the United States
Authors: Han Sola , Sohn Ted J. , Avanceña Anton L.V. , Park Chanhyun
Published: November 2023

Background: Cardiovascular disease (CVD) can lead to unplanned care in patients with cancer, which may affect their prognosis and survival. We aimed to compare the rates, timing, and length of stay of unplanned CVD readmission in hospitalized patients with and without cancer. Methods: This study used the 2017–2018 Nationwide Readmissions Database to identify adult hospitalized patients with and without cancer. The primary outcome was 180-day unplanned CVD readmission rates. CVD was defined based on a composite variable that included atrial fibrillation, coronary artery disease, cardiomegaly, cardiomyopathy, heart failure, peripheral artery disease, and stroke. For patients readmitted due to CVD, the timing between admissions (based on the mean number of days between index hospitalization and readmission) and length of stay were further identified. Results: After matching, 300,398 patients were included in the two groups. The composite CVD readmission rates were significantly higher in patients with cancer (5.92% vs 4.10%; odds ratio (OR) 1.47, 95% CI 1.44–1.51, p < 0.001). Patients with cancer were also associated with shorter mean number of days to composite CVD readmission (60.48 days vs 68.32 days, p < 0.001) and longer length of stay of composite CVD readmission (8.21 days vs 7.13 days, p < 0.001). These trends were maintained in analyses of the individual CVD. Conclusions: Hospitalized patients with cancer experienced higher rates of unplanned readmission due to CVD, and their CVD readmissions occurred sooner and required longer lengths of stay compared to patients without cancer. Efforts to reduce unplanned CVD readmissions, such as providing optimized chronic post-discharge care, may improve the health outcomes of patients with cancer.
Moderate Ischemic Mitral Regurgitation with Ejection Fraction <40% Undergoing Concomitant Mitral Valve Repair during Revascularization: A Single-Center Observational Study
Authors: Yang Ye , Liu Fangyu , Wang Yulin , Xia Limin , Wang Chunsheng , Ji Qiang
Published: November 2023

Background: Numerous studies have examined the therapeutic effects of mitral valve repair during revascularization on moderate ischemic mitral regurgitation (IMR), as well as the incremental benefit of subvalvular repair alongside an annuloplasty ring. However, the impact of depressed left ventricular (LV) function on the surgical outcome of patients with moderate IMR has been rarely investigated. The aims of this single-center, retrospective, observational study were firstly to evaluate short- and medium-term outcomes in this patient group after undergoing mitral valve repair during revascularization, and secondly to assess the impact of depressed LV function on surgical outcomes. Methods: A total of 272 eligible patients who had moderate IMR and underwent concomitant mitral valve repair and revascularization from January 2010 to December 2017 were included in the study. These patients were categorized into different groups based on their ejection fraction (EF) levels: an EF <40% group (n = 90) and an EF ≥40% group (n = 182). The median time course of follow-up was 42 months and the shortest follow-up time was 30 months. This study compared in-hospital outcomes (major postoperative morbidity and surgical mortality) as well as midterm outcomes (moderate or more mitral regurgitation, all-cause mortality, and reoperation) of the two groups before and after propensity score (PS) matching (1:1). Results: No significant difference was observed in surgical mortality between groups (8.9% vs. 3.3%, p = 0.076). More patients in the EF <40% group developed low cardiac output (8.9% vs. 2.7%, p = 0.034) and prolonged ventilation (13.3% vs. 5.5%, p = 0.026) compared to the EF ≥40% group. Propensity score (PS) matching successfully established 82 patient pairs in a 1:1 ratio. No significance was discovered between the matched cohorts in terms of major postoperative morbidity and surgical mortality, except for prolonged ventilation. Conditional mixed-effects logistic regression analysis revealed that EF <40% had an independent impact on prolonged ventilation (odds ratio (OR) = 2.814, 95% CI 1.321–6.151, p = 0.031), but was not an independent risk factor for surgical mortality (OR = 2.967, 95% CI 0.712–7.245, p = 0.138) or other major postoperative morbidity. Furthermore, the two groups showed similar cumulative survival before (log-rank p = 0.278) and after (stratified log-rank p = 0.832) PS matching. Cox regression analysis suggested that EF <40% was not related to mortality compared with EF ≥40% (PS-adjusted hazard ratio (HR) = 1.151, 95% CI 0.763–1.952, p = 0.281). Conclusions: Patients with moderate IMR and EF <40% shared similar midterm outcomes and surgical mortality to patients with moderate IMR and EF ≥40%, but received prolonged ventilation more often. Depressed LV function may be not associated with surgical or midterm mortality.
Prognostic Significance of Peripheral Artery Disease in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Authors: Xia Yihua , Han Kangning , Cheng Yujing , Wang Zhijian , Gao Fei , Ma Xiaoteng , Zhou Yujie
Published: November 2023

Background: Peripheral artery disease (PAD) elevates the risk of adverse outcomes. The current work aimed to evaluate the influence of PAD in acute coronary syndrome (ACS) cases administered percutaneous coronary intervention (PCI), and to determine whether PAD adds incremental prognostic value to the global registry of acute coronary events (GRACE) scale. Methods: To retrospectively analyze a single-center, prospective cohort trial, we consecutively included ACS cases administered PCI. Individuals with and without PAD were comparatively examined for clinical outcomes. The primary endpoint was major adverse cardiovascular events (MACEs), a compound item encompassing all-cause death, myocardial infarction (MI), stroke and repeat revascularization. The added value of PAD based on a reference model was examined. Results: PAD was detected in 179 (10.4%) of the 1,770 included patients. The incidence rates of MACEs (40.3% vs. 17.9%), all-cause death (11.2% vs. 1.6%), cardiovascular death (8.9% vs. 1.4%), MI (8.4% vs. 2.2%) and repeat revascularization (30.2% vs. 15.2%) were all markedly elevated in PAD cases in comparison with the non-PAD group (p < 0.001). After adjusting for other confounding variates, PAD independently predicted MACE occurrence (hazard ratio = 1.735, 95% confidence interval: 1.281–2.351). Addition of PAD resulted in remarkably increased predictive performance for MACE compared to the baseline GRACE score (Harrell’s C-statistic: 0.610 vs. 0.587, p < 0.001; net reclassification improvement: 0.134, p < 0.001; integrated discrimination improvement: 0.035, p < 0.001). Conclusions: In ACS cases administered PCI, PAD independently worsens clinical outcomes and adds incremental value to the GRACE risk score.
Forskare som noviser inom vetenskapsfostran av barn
Authors: Aaltonen Martina , Holm Gunilla
Published: November 2023

Studien bidrar till kunskap om hurdant stöd forskare utan lärarbehörighet eller tidigare gedigen erfarenhet av att undervisa barn upplever att de behöver för att klara av att planera och leda en framgångsrik vetenskaplig verkstad för barn i åk 3–6, samt kunskap om vad forskarna upplevde att de själv lärde sig av uppdraget. Tio personer som lett en vetenskaplig verkstad för barn intervjuades inom U-projektet som ordnar vetenskapliga verkstäder för barn i åk 3–6 i Finland som hobbyverksamhet. Sex av de intervjuade personerna hade inte tidigare gedigen erfarenhet av att undervisa barn i samma ålder eller lärarbehörighet medan fyra av de intervjuade också var lärare. Studien indikerar att uppdraget att planera och leda en vetenskaplig verkstad för barn i åk 3–6 kan vara en trygg, trevlig och lärorik erfarenhet för forskare utan tidigare erfarenhet av att undervisa barn då tillräckligt stöd erbjuds före och under verkstaden. Studien indikerar också att uppdraget ligger inom ZPD för dessa forskare, vilket innebär att stödet före och under verkstaden inte bara var värdefullt utan också centralt för forskarna. Tidigare studier har visat att det har varit lärorikt för forskare att delta i vetenskapsfostran av barn i skolkontext. Denna studie visar att samma gäller vetenskapsfostran av barn som hobbyverksamhet.
Compte rendu: Mokhtar Amoudi, Les Conditions idéales, Paris, Gallimard, 2023
Authors:   Universitatea din Bucureşti, Académie de Lyon, Franţa, Giroud Adnana
Published: November 2023

Book review
Navigating the Future: Human-Centric Integration of AI and Robotics
Authors: Tobiloba Bamigboye , Tera Terry , Kelvin Lawrence
Published: November 2023

As technology propels us into a future characterized by unprecedented AI and roboticsintegration, this article champions a human-centric paradigm. In this exploration, we delve intothe historical underpinnings of human influence on technology, tracing the threads of intuition,empathy, and creativity. Through compelling examples, we illuminate how AI and robotics,when harnessed judiciously, can amplify human capabilities. Addressing societal needs becomesa focal point, emphasizing the ethical considerations and human responsibility essential fornavigating this technological landscape. The discourse extends to the harmonization oftechnology with human values, aligning with cultural, ethical, and moral perspectives. Amidstthe possibilities, challenges and limitations are acknowledged, underlining the significance ofhuman oversight and risk mitigation. This article calls for a future where technology, guided by aresolute human touch, advances responsibly and harmoniously.
Sistem Otomasi Sistem Pengendalian
Authors: Madani Muhammad Ashim
Published: November 2023

Perguruan tinggi merupakan ujung tombak pengembangan inovasi, kreativitas, inovasi dan pengembangan manusia secara responsif. Universitas atau perguruan tinggi diharapkan untuk dapat meningkatkan kualitas dan relevansinya dengan melakukan reformasi atas tata kelola organisasinya dari waktu ke waktu. Hal ini perlu dilakukan untuk menjawab berbagai tantangan dan perubahan yang cepat pada lingkungan yang terus berkembang .Tujuan pendidikan tersebut dapat dicapai bila mutu pendidikan yang ditawarkan oleh perguruan tinggi di Indonesia juga baik. Mutu pendidikan ini dapat dilihat dari kinerja perguruan tinggi itu sendiri. Kinerja perguruan tinggi di Indonesia dapat dilihat dari pemeringkatan perguruan tinggi yang dilakukan oleh Kementrian Riset dan Teknologi Direktorat Pendidikan Tinggi (Kemenristekdikti) berdasarkan pada penilaian akademik dan non akademik.
Building energy use in COVID-19 lockdowns: did much change?
Authors: Hollick Frances , Humphrey Dominic , Oreszczyn Tadeusz , Elwell Cliff , Huebner Gesche
Published: November 2023

The UK national lockdowns introduced to prevent the spread of COVID-19 had huge impacts on daily lives, as people were largely confined to their homes. It could be expected that residential energy use would drastically increase while non-residential decreased, however the picture is not so clear. In this paper three complementary datasets on different scales are used to explore changes in building energy use during two national lockdowns (spring 2020 and winter 2021): the complete building stock of Great Britain, a sample of ~1000 residential buildings, and a sample of ~24,000 residential boilers. Energy signature analysis was used for the building data to estimate the changes in energy consumption for space heating and otherwise, with the boiler data able to separate space and water heating and explore changes in these. In the 2020 lockdown residential energy consumption for water heating and appliances increased, with decreased use for heating, resulting in a reduction in total energy use during the heating season. In the 2021 lockdown total energy consumption changed little, however a decrease in the use of gas space heating was observed. These residential changes counteracted any non-domestic changes, resulting in little difference in national energy consumption.
Digital marketing dalam islam
Authors: FAJAR
Published: November 2023

Evolusi komunikasi melalui media sosial telah menyebabkan lonjakan informasi dan konten online. Munculnya media Digital dimulai pada akhir 1930-an dengan penemuan komputer dan iterasi Internet yang mencakup berbagai teknologi. Sejak awal abad ke-21, banyak analis media dan sarjana ilmu sosial telah mempengaruhi dinamika perubahan dalam komunikasi publik dan media. Akibatnya, media sosial telah mengubah komunikasi dan interaksi individu secara global dengan memengaruhi banyak aspek komunikasi manusia termasuk perilaku. Dalam beberapa tahun terakhir, media sosial dan situs jaringan seperti Instagram, YouTube, Facebook, Twitter, dan Tiktok, antara lain, telah menjadi praktik sehari-hari bagi sebagian besar pengguna, termasuk wisatawan dan alat penting untuk mendapatkan informasi mendalam tentang situs
Sistem Otomasi Pengendalian Suhu
Authors: Helmi Guswita
Published: November 2023

Burung walet merupakan ternak unggas yang dibudidayakan dengan sarang sebagai produksi utama. Umumya burung wallet menyenangi tempat yang bersuhu hangat sebagai tempat tinggalnya untuk membuat sarang, selain itu keadaan suhu dan kelembaban udara yang stabil dapat menghasilkan sarang burung walet yang berkualitas sehingga memiliki harga jual yang tinggi. Oleh sebab itu penerangan yang mirip dengan gua-gua alami yang remang-remang maupun gelap pada umumnya sangat disukai oleh burung walet untuk dijadikan sebagai sarang, sehingga peternak walet biasanya menggunakan berbagai media untuk membuat ruangan jadi gelap, seperti menggunakan cat dinding warna hitam, namun hal ini tidak disukai oleh burung walet karena umumnya sangat sensitif terhadap bau yang pekat sehingga hanya akan membuat burung walet tidak tinggal di dalam ruangan tersebut. Rancangan sistem pengendali suhu kelembaban dan cahaya pada rumah walet berbasis mikrokontroller ini dirancang dengan tujuan untuk mempermudah peternak melakukan pengontrolan secara berkala. Hasil penelitian ini diharapkan dapat memberikan keriganan bagi para peternak sehingga mereka tidak terlalu banyak membuang waktu untuk mengurus rumah walet.
Automated Deduction in Propositional Product Logic
Authors: Guller Dusan
Published: November 2023

The product logic belongs to the basic fuzzy logics with continuous t-norms, exploiting the multiplication t-norm on the unit interval [0,1].This paper investigates the propositional product logic from a computational perspective.Our aim is to accommodate well-established automated deduction (theorem proving) to fuzzy inference.As a first step, we generalise the procedure of Davis, Putnam, Logemann, and Loveland (DPLL) to the context of the product logic.We provide the proof that the procedure is refutation sound and finitely complete as well.As a consequence, solutions to the deduction, satisfiability, and validity problems will be presented for the finite case.The achieved results contribute to the theoretical (logic and computational) description of fuzzy inference.
Application of Strategic Process Model to Military Strategy Studies
Authors: Yu Chen
Published: November 2023

This article explores the application of Henry Mintzberg’s Strategic Process Model to analyze and enhance adaptive strategy in military operations. The model's components, including emergent strategy, organic structure, learning and feedback loops, and scenario planning, are examined in the context of military organizations' response to dynamic threats and changing environmental conditions. By leveraging the model, military leaders and strategists can navigate uncertainty, make rapid adjustments, and capitalize on emerging opportunities while addressing dynamic threats. Envisioning 8 application scenarios, the article highlights the model's significance in facilitating decentralized decision-making, institutionalized learning, and future-oriented planning to ensure readiness and agility in the face of complex and unpredictable challenges.
Sistem Otomasi Pengendalian Kelembaban
Authors: Helmi Guswita
Published: November 2023

Internet of things dalam pengertian secara luas membuat semuayang ada di dunia terkoneksi ke dalam internet yang tersambungsecara terus menerus. Internet of things bisa mengontrol, mengirimdata, dan sebagainya yang memanfaatkan internet sehingga bisadilakukan dengan jarak jauh tanpa mengenal jarak. Implementasisaat ini pengendalian kelembaban udara masih dilakukan denganmerasakan langsung melalui kulit manusia kemudian akanmelakukan pengkabutan apabila kelembaban dirasa kurang.Dengan adanya internet of things dapat diimplementasikanpengendali kelembaban udara dari jarak jauh melalui website.Untuk melakukan pembuatan pengendali kelembaban udaradiperlukan alat seperti sensor kelembaban dan temperatur udaraSHT11, mikrokontroler, relay, sprayer.Untuk hubungan interaksi sensor kelembaban dan temperaturudara, mikrokontroler, ataupun alat bantu lainnya melalui internetdigunakan website. Website ini digunakan untuk mempermudahpengguna untuk mengakses internet dimanapun dan menggunakandevice yang mampu membuka website. Website dibuat denganmenggunakan php. Mikrokontroler yang digunakan adalah WeMosD1 R2 yang terdapat ESP8266 didalamnya.Hasil akhir dari pengembangan pengendali kelembaban udara iniadalah mikrokontroler dapat mengirimkan data dari sensor ke webserver, kelembaban udara yang sesuai dengan setpoint. Penggunadapat melihat grafik kelembaban dan temperatur udara per-hari.
Bàn về “vũ khí hóa” nghị sự chống khủng hoảng khí hậu và sinh thái: Rủi ro, thực tế và hậu quả
Authors: Hoàng Vương Quân , Phương Lã Việt , Hoàng Nguyễn Minh
Published: November 2023

Trong những năm gần đây, tính cấp thiết và tầm quan trọng của việc giải quyết vấn đề biến đổi khí hậu ngày càng gia tăng, từ một vấn đề thuần túy về môi trường, nó đã trở thành một thách thức chính trị - xã hội phức tạp. Thậm chí, một số nhà nghiên cứu cho rằng tác động của biến đổi khí hậu toàn cầu đối với an ninh quốc tế có thể mang tính lịch sử, thách thức hơn những mối đe dọa toàn cầu trước đây như phổ biến vũ khí hạt nhân, Đại suy thoái và khủng bố. (Kinh tế và Dự báo; ngày 23/11/2023)
Real-time incentivizing survey completion with game-based rewards in experience sampling research may increase data quantity, but reduces data quality☆
Authors: Dejonckheere Egon , Verdonck Stijn , andries Joren , Röhrig Natalie , Piot Maarten , kilani ghijs , Mestdagh Merijn
Published: November 2023

Experience sampling methodology (ESM) requires participants to repeatedly rate various psychological states in everyday life. This can be quite burdensome, leading to frequently skipped or missed assessments that undermine the ecological validity of collected data. Financially compensating participants for their effort may counter suboptimal response rates, but monetary rewards are not always feasible or ethical, and are unfitting to counter non-response in the moment. Here, we investigated the potential of gamification as a momentary reward strategy to encourage survey completion. In a between-person experiment, we randomly assigned 193 participants to take part in a gamified or standard ESM protocol. Upon completing a survey in the gamified condition, participants immediately received some virtual coins to purchase various in-app rewards (fun facts or personalized graphs). Gamifying momentary survey completion resulted in higher response rates and shorter latencies, but only for participants who frequently bought rewards in the coin store. Paradoxically, gamification also caused participants’ responses to be more unreliable. Completion times did not differ. The reward schemes of future ESM studies should focus on both response quantity and quality. To further explore the potential of momentary incentive strategies, we provide open access to customizable gamification building blocks within our ESM platform, m-Path.
“The whole thing is a juggling act”: Qualitative Exploration of Goal Systems among Activists and Nonactivists
Authors: Grzymala-Moszczynska Joanna , Coenen Ann-Cathrin , Jasko Katarzyna , Gore-Gorszewska Gabriela , Kunst Jonas R. , Kałwak Weronika
Published: November 2023

Whereas the importance of considering the relationships between multiple goals is acknowledged within motivational frameworks, it has received surprisingly little attention in the political domain. Using the motivational perspective of goal systems theory (Kruglanski et al., 2002), the present study explored the relationships between political goals and other life goals among individuals with varying levels of political engagement. Through 40 qualitative, preregistered, semi-structured interviews conducted with activists and non-activists from Poland and Norway, we examined how they experience their political and non-political goals and the relationships between them. The results uncover complex relationships between political engagement and life goals related to work, relationships, health, and personal growth, as well as basic psychological needs. These connections can lead to conflicts with potential negative consequences, yet they can also serve as facilitators of political engagement. We identified distinct goal structures, offering insights into the motivational dynamic of activists, non-activists, and former activists.
A metabolic trade-off impacting childhood language development and body growth
Authors: Bouton Sophie , Chevallier Coralie , Cissé Aminata Hallimat , Heude Barbara , Jacquet Pierre O.
Published: November 2023

During human childhood, brain development and body growth compete for limited metabolic resources, resulting in a trade-off where energy allocated to brain development can decrease as body growth accelerates. This preregistered study explores the potential links between language skills, used as a proxy for brain development, and body mass index at 3 distinct developmental stages, serving as proxies for body growth. Analyzing longitudinal data from 2002 children in the EDEN mother-child cohort using structural equation modeling, we identified a compelling pattern of associations: girls with a delayed adiposity rebound, signaling slower growth rate, demonstrated better language proficiency at ages 5-6. Importantly, this correlation appears specific to language skills and does not extend to non-verbal cognitive abilities. Exploratory analyses show that early environmental factors that contribute to enhanced cognitive development, such as higher parental socio-economic status and higher levels of cognitive stimulation, are positively linked to both language skills and the age at which adiposity rebound occurs in girls. Overall, our findings lend support to the existence of an energy allocation trade-off mechanism that appears to prioritize language function over body growth investment, in girls.