bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning Organizations and Competitive Advantage as Mediating the Effect of Network Capability on Organizational Performance
Authors: Bunyamin Bunyamin , Kadarusman Kadarusman
Published: June 2023

This study aims to test the effect between the Network Capability and Organizational Performance and Learning Organization, with the Competitive Advantage being served as the moderating variable conducted at Small and Medium Enterprises (SME) in Malang city. This study was done by distributing the questioners filled in by the owners and the heads of the small and medium enterprises firms in Malang city. The data was processed using smartpls program. The result shows that the Network Capability directly affects the Organizational Performance, Learning Organization, and Competitive Advantage. Organizational Performance is also directly and positively affected by the Learning Organization and Competitive Advantage.  The indirect effect suggests that the Learning Organization and Competitive Advantage are variables that mediate the effect between the Network Capability and Organizational Performance and serve as partial mediation. Based on this study, it is hoped that it gives. This result is expected to give a deeper understanding of the importance of the strategy implementation referring to the resource-based view of the organization. The Network Capability improvement can be a trigger to develop the organization's learning capability, competitive and organizational performance. Practically, is expected to be implemented within an organization to collaborate either with internal or external parties
Manajemen Strategik dalam Transformasi Koperasi Himpunan Pedagang Pasar Cikapundung Menuju Koperasi Modern
Authors: Suarna Indri Ferdiani , Rahayu Agus , Adi Wibowo Lili
Published: June 2023

Di era new normal koperasi diharapkan dapat terus kreatif dan responsif dalam menjalankan bisnis usahanya. Melalui modernisasi koperasi dengan memanfaatkan teknologi digital menjadi strategi inovasi untuk mencapai efisiensi dan aktivitas layanan koperasi. Koperasi modern juga harus memiliki skala usaha dan kapasitas produksi besar, melakukan sinergi antar pihak berbasis ekosistem, serta dikelola oleh manajemen profesional. Koperasi pasar bisa jadi role model koperasi modern. Penelitian ini bertujuan untuk mengetahui faktor-faktor internal dan eksternal yang mempengaruhi kinerja Koperasi Himpunan Pedagang Pasar Cikapundung (KOHIPPCI) mengidentifikasi posisi koperasi dengan analisis matriks internal eksternal, grand strategy matrix, GE matriks, BCG matriks, dan TOWS matriks, serta menemukan alternatif strategi yang bisa dikembangkan untuk meningkatkan kinerja koperasi tersebut. Penelitian menggunakan metode deskriptif kualitatif dengan analisis SWOT yang dikembangkan untuk mengidentifikasi Strategic Factor Analysis Summary (SFAS). Hasil penelitian menunjukkan ada banyak kekuatan dan kelemahan dari lingkungan internal serta peluang dan ancaman dari faktor eksternal terhadap KOHIPPCI. Meski demikian, KOHIPPCI masih mampu mengelola faktor-faktor tersebut yang ditunjukkan dengan posisinya pada kelompok tumbuh dan bangun pada matriks internal eksternal serta kuadran I grand strategy matrix, GE matriks di kuadran V dan BCG matriks di posisi cash flow.
The Effect of State Sukuk and Macroeconomics on The Trading Volume of Corporate Sukuk with Yield and Sukuk Rating as Control Variables
Authors: Purniaji Mellyana Alvi , Sunarsih Sunarsih
Published: June 2023

Penelitian ini bertujuan untuk menganalisis pengaruh sukuk negara dan makroekonomi terhadap volume perdagangan sukuk korporasi di pasar sekunder Indonesia dengan yield dan peringkat sukuk korporasi sebagai variabel kontrol. Metode yang digunakan dalam penelitian ini adalah analisis regresi data panel dengan menggunakan alat uji Stata-14. Hasil penelitian ini menemukan bahwa setelah menggunakan variabel kontrol variabel sukuk negara yang diukur dengan nilai outstanding sukuk ritel berpengaruh negatif signifikan terhadap volume perdagangan sukuk korporasi di pasar sekunder dan variabel pertumbuhan ekonomi (GDP) berpengaruh positif signifikan terhadap volume perdagangan sukuk korporasi di pasar sekunder Indonesia. Sementara variabel inflasi dan suku bunga tidak berpengaruh terhadap volume perdagangan sukuk korporasi di pasar sekunder Indonesia
Impact of The Covid 19 Pandemic: Is There Overreaction in LQ 45 Stock?
Authors: Rizal Riadi Deden , Garnia Erna , Tahmat T Tahmat
Published: June 2023

The Covid-19 pandemic has had an impact on various aspects of life, including the capital market which has caused a negative response on most stock exchanges around the world, including the Indonesia Stock Exchange. The Effecieny Market Hypothesis (EMH) explains that the price of a stock will always be reflected from the information available in the market or investors tend to be rational. However, dramatic events such as COVID-19 allow investors to overreact. The results showed that there was an overreaction in both winner and loser stocks in the LQ 45 group on the IDX in 3 months of observation since covid was announced as a pandemic. This overreaction is then followed by a price reversal even though it has not given a significant return after t+13 for both winner and losser stocks. The speed of price recovery (magnitude effect) after the price reversal on the loser stock is higher (faster) than the winner stock. The speed of this price recovery is significantly affected by the company's capital structure and share ownership of individual investors (local and foreign).
Pengaruh Program KUR dan BLT terhadap Kinerja UMKM dengan Strategi Diferensiasi sebagai Variabel Mediasi
Authors: Suryani Irma , Rita Maria Rio
Published: June 2023

This study aims to examine the impact of the Kredit Usaha Rakyat (KUR) and Bantuan Langsung Tunai (BLT) programs on the performance of MSMEs through differentiating mediation strategies. This study involved SMEs in Salatiga City using a purposive sampling method to purchase samples. Data is processed using Partial Least Square-Structural Equation Modeling (PLS-SEM). The reported findings are that the KUR and BLT programs have a significant positive effect on the differentiation strategy and also on the performance of MSMEs. It is also proven that differences in strategy mediate the effect of the KUR and BLT programs on MSME performance. This can be a reference for MSME actors to increase capital in a business by wisely using the KUR and/or BLT programs to support the implementation of a differentiation strategy to improve operations.
Peran Barrier Memoderasi Pengaruh Motivasi dan Enabler terhadap Perilaku Berbagi Pengetahuan Pegawai
Authors: Yoasti Ilafi Rani , Riwayati Hedwigis Esti , Ovalia  , Iqbal Muhammad
Published: June 2023

This study aims to investigate and analyze the effect of motivation, enabler and enabler on knowledge sharing behavior in Ministry of Finance with barrier as moderating variable. This study adopts a quantitative method with a sample of 100 employees of Ministry of Finance. The data employed are primary data derived from questionnaire. Moderated Regression Analysis (MRA) is used to analyse the data. From the results of the study, it was found that motivation and enabler had a significant and positive effect on the knowledge sharing behavior of Ministry of Finance employees. The results also showed that the barrier did not moderate the influence of motivation or enabler on the knowledge sharing behavior of MoF employees.
Analisis Komparasi Kinerja Keuangan PT Bank BTPN. Tbk Sebelum dan Sesudah Merger
Authors: Anabella Nike , Intanie dewi Vera
Published: June 2023

The purpose of this study is to conduct a comparative test of Bank BTPN Tbk.,financial performance before and after the merger using the Risk-Based Bank Rating approach. The method used is verificative study, carried out by conducting a paired t-test of two samples. This study found that Bank BTPN Tbk. financial performancedeclined after the merger. This is indicated by the increasing LDR, indicating that the bank's liquidity risk becomes greater after the merger. The NIM and ROA ratios were smaller and the BOPO ratio increased after the merger, indicating that Bank BTPN Tbk. ability to generate profits has decreased. The level of bank capital with the CAR indicator also decreased. Based on the results of comparative analysis, it can be proven that there are differences in the financial performance of Bank BTPN between before and after the merger
Undang-Undang Peradilan Agama 1989 dalam Tinjauan Pemikiran Mark Cammack
Authors: Ichwan Ahnaz Alamudi Ichwan Ahnaz Alamudi
Published: June 2023

Penelitian ini dilatarbelakangi oleh sahnya Undang-Undang Nomor 7 tahun 1989 tentang Peradilan Agama oleh Presiden Soeharto. Sebelum berlakunya UU tersebut, kompetensi substantif pengadilan Islam di pulau-pulau padat penduduk di Jawa dan Madura hanya mencakup masalah perkawinan dan perceraian dengan adanya undang-undang ini menambah yurisdiksi pengadilan Islam untuk memasukkan warisan di seluruh negeri. Penelitian ini merupakan penelitian normatif yang bertujuan untuk mengetahui pemikiran dan pembahasan terkait lahirnya Undang-Undang Peradilan Agama tahun 1989. Hasil penelitian ini memperlihatkan bahwa Peradilan Agama telah hadir dalam bagian hukum di Indonesia sejak masuknya Agama Islam ke Indonesia, hal tersebut dalam rangka memenuhi kebutuhan masyarakat muslim akan penegakkan keadilan, pemerintah mewujudkan dan menegaskan kedudukan peradilan agama di Indonesia. Pengesahan Undang-Undang Peradilan Agama 1989 menjadikan Peradilan Agama memiliki kedudukan yang sejajar dengan peradilan-peradilan lainnya.
PRILAKU SOSIAL KEAGAMAAN BURUH TANI DI SUNGKAI JAYA LAMPUNG UTARA
Authors: Arifa Reza Nur
Published: June 2023

Perilaku sosial keagamaan adalah melaksanakan ajaran agama yang dilakukan dengan sadar dan kesungguhan hati yang di praktik kan di lapisan sosial masyarakat. Tujuan dari penelitian ini untuk mengetahui perilaku sosial keagamaan buruh tani di Sungkai Jaya, Lampung Utara serta faktor penghambat buruh tani dalam melaksanakan praktik sosial keagamaan yang ada di Sungkai Jaya, Lampung Utara. Metode yang digunakan adalah metode deskriptif kualitatif. Data di peroleh melalui metode observasi, wawancara dan dokumentasi. Penyajian dan analisis data di narasikan secara deskripsi kualitatif  dengan melalui tiga tahap yaitu reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukan bahwa perilaku sosial buruh tani sangat baik dilihat dari kegiatan gotong royong, menjenguk orang sakit, ronda malam, serta tolong menolong yang masih diterapkan hingga saat ini akan tetapi untuk keagamaannya sendiri masih kurang dilihat dari ketika waktu shalat tiba buruh tani masih tetap berada diladang contohnya saja pada waktu shalat Dzuhur tiba mereka menggunakan waktunya untuk beristirahat tidak untuk beribadah sama halnya dengan hari Jum’at hanya sedikit yang datang untuk melaksanakan shalat Jum’at di masjid. Faktor penghambat untuk melaksanakan kegiatan sosial keagamaan adalah rendahnya ekonomi buruh tani yang memaksa mereka menghabiskan waktu bekerja keras agar dapat memenuhi kebutuhan hidup serta tingkat pendidikan yang rendah sehingga mereka tidak mempunyai pilihan lain selain bekerja sebagai buruh tani.
PEMASYARAKATAN PROFETIK : TINJAUAN POLITIK PROFETIK TERHADAP UNDANG-UNDANG NOMOR 22 TAHUN 2022
Authors: Daulay Royyan Mahmuda Al'Arisyi
Published: June 2023

Undang-Undang Nomor 22 Tahun 2022 tentang Pemasyarakatan merupakan kebijakan baru oleh Negara dalam penyelenggaraan sistem kepenjaraan nasional. Namun, dalam proses legislasi kebijakan ini banyak mengalami penolakan akibat image buruk yang sering didengar oleh masyarakat. Padahal kebijakan ini memuat nilai-nilai yang hidup dalam masyarakat, agama dan pancasila. Atas dasar itu, penelitian ini memiliki tujuan untuk menggali nilai-nilai pemasyarakatan dengan tinjauan politik profetik. Teori politik profetik memiliki 3 unsur, yaitu humanisasi, liberasi dan transendensi. Jenis penelitian ini adalah  penelitian kualitatif kepustakaan dengan pendekatan normatif-yuridis menggunakan metode deskriptif-analitik. Data primer adalah Undang-Undang Nomor 22 Tahun 2022 dan data sekunder adalah literatur tentang politik profetik. Data-data tersebut dikumpulkan lalu dianalisis serta dideskripsikan secara komprehensif. Menurut pandangan politik profetik, pemasyarakatan dalam Undang-Undang Nomor 22 Tahun 2022 memuat nilai-nilai humanisasi, liberasi dan transendensi di dalam asas dan pasal-pasalnya. Nilai profetik tercermin pada asas-asas seperti asas pengayoman, persamaan perlakuan dan pelayanan, penghormatan harkat dan martabat manusia, kehilangan kemerdekaan merupakan satu-satunya penderitaan, dan terjaminnya hak untuk tetap berhubungan dengan keluarga dan orang-orang tertentu. Sehingga bisa dikatakan bahwa Undang-Undang No. 22 Tahun 2022 tentang Pemasyarakatan sebagai kebijakan yang memiliki nilai-nilai politik profetik. Kajian tentang pemasyarakatan perlu ditingkatkan agar menambah khazanah keilmuan tentang sistem kepenjaraan. Serta menambah pengetahuan publik tentang nilai-nilai positif pemasyarakatan.
ANALISIS OPTIMALISASI MANAJEMEN EKONOMI PONDOK PESANTREN NURUL HUDA KOTA TANGGERANG
Authors: Najib Murobbi Muhammad
Published: June 2023

Tujuan dari penelitian ini adalah untuk dapat mengetahui bagaimana model pentahelix dalam mengoptimalkan pengelolaan unit usaha pemupukan pondok pesantren. Dalam proses optimalisasi pondok pesantren Nurul Huda menerapkan ilmu manajemen, pelatihan kewirausahaan dan pelatihan santripeneur. Penelitian ini menggunakan pendekatan kualitatif dengan pengumpulan data melalui wawancara, observasi dan dokumentasi. Metode muwajjahah sebagai metode pelatihan program santripeneuer yaitu berupa pupuk tanaman UD Mitra Pesantren Berkah Tani. Hasil penelitian menunjukkan bahwa optimalisasi dapat diketahui dengan menerapkan model pentahelix yang terdiri dari akademisi, pelaku bisnis, pemerintah, komunitas, dan media. Akademisi terdiri dari guru, pembina kewirausahaan dan pihak-pihak yang terkait dengan santripenuer. Pelaku usaha terdiri dari tim produksi pupuk UD Mitra Pesantren. Pemerintah beranggotakan Forum Silaturahmi Pesantren (FSPP) Kota Tangerang yang merupakan naungan Kementerian Agama. Masyarakat terdiri dari perusahaan dan pabrik yang berperan sebagai akselerator dalam proses pengembangan santripenuer, dan media merupakan strategi pemasaran dalam proses penjualan pupuk. Sebagai bentuk optimalisasi berkelanjutan, pondok pesantren Nurul Huda harus mampu menyeimbangkan santri dengan bekal berupa kurikulum sebagai acuan pembelajaran dan pembinaan santri. Di beberapa pesantren di Indonesia, belum banyak pesantren yang menerapkan pentahelix model ini sebagai optimalisasi. Penelitian ini diharapkan dapat memberikan pengetahuan yang lebih luas tentang optimalisasi manajemen.
Pelatihan Penulisan Karya Tulis Ilmiah Bagi Guru dan Mahasiswa di Kota Tangerang
Authors: Latuconsina Hudaya , Atrisia Marchela Indah , Khusaini - , Kurniawati Ria
Published: June 2023

Kegiatan pelatihan penulisan karya tulis ilmiah ini bertujuan untuk meningkatkan keterampilan riset dan publikasi para guru dan mahasiswa. Kegiatan ini diikuti 43 peserta yang terdiri dari para guru dan mahasiswa. Metode pelaksanaan kegiatan meliputi tahapan persiapan, pelaksanaan, evaluasi dan pelaporan. Sedangkan teknik pelaksanaan kegiatan pelatihan adalah secara daring.  Hasil kegiatan pelatihan ini menunjukkan bahwa peserta merasa cukup puas dengan kegiatan pelatihan ini.  Selama pelaksanaan kegiatan pengabdian kepada masyarakat, para guru dan mahasiswa konsisten mengikuti kegiatan dengan baik. Kegiatan ini memberikan kontribusi kepada para guru dan mahasiswa dalam meningkatkan pengetahuan, pemahaman, dan keterampilan dalam penulisan karya ilmiah. Selain itu, dengan diadakannya pelatihan ini diharapkan guru dapat melaksanakan kegiatan pembelajaran yang lebih berkualitas. Dengan demikian, perlu adanya pelatihan bagi guru dan mahasiswa agar dapat menuliskan hasil tersebut ke dalam karya ilmiah.
Assessment of the suitability of soils for the production of organic plant production at the local level of territory development
Authors: Podzerei R.
Published: June 2023

The development of organic production in Ukraine is a promising and relevant issue today. Organic farming has many advantages, including the preservation of soil fertility, reduced environmental impact, and the provision of high-quality and safe products. A farm that utilizes its fertile soil for organic production can have a positive impact on the quality of its products and increase their value on the market. It is important to note that maintaining organic farming requires systematic work to support soil fertility. That is why it is recommended to regularly conduct agrochemical analyses and implement restorative measures to increase soil fertility. The article provides scientific evidence that the soils of the agricultural company “Bazis” located in the Uman district of Cherkasy region are suitable for the production of organic crops. To do this, an assessment of the territorial location relative to possible sources of anthropogenic impact and radiation contamination of the territory was carried out. In the settlement, there is no landfill for solid household waste and storage facilities for pesticides and chemicals. The main polluting enterprises are located 12 km away, in the district center, Uman. Сontinuous agrochemical land survey of agricultural land was conducted. This analysis allowed us to establish that the soils have an optimal level of humus and nutrients, do not contain harmful metals and other toxic substances. Thus, it can be stated that the soils of the farm of the agricultural company “Bazys” of the Uman district, Cherkasy region are suitable for growing organic plant products, which guarantees the quality and safety of the produced products.
Solar
light assisted degradation of Rhodamine B dye by chemically synthesized silver
nanoparticles
Authors: Chandulal Vithalani Priya , Sumantray Bhatt Nikhil
Published: June 2023

Utilization of dyes and dyestuff is increasing day by day, which affects environmental health and sustainability. Rhodamine B (RhB) is a synthetic xanthene class of dye that has a major application in cosmetic, painting, printing, and textile industries. The toxicity of RhB has been reported in animals, insects as well as humans in parts per billion (ppb) concentration. Exposure to this dye causes skin irritation, nervous system issues, and developmental changes. Therefore, the remediation of the dye is a crucial factor. The aim of this study was solar-assisted photocatalytic degradation of RhB. Synthesis of silver nanoparticles (AgNPs) was carried out with chemical reduction method, and characterization with the X-ray diffraction (XRD). The photocatalytic activity was checked with 1000 mL wastewater in which 10 ppm dye was added. Optimization of physicochemical parameters was performed by one-factor-at-a-time (OFAT) method. Maximum 99.32 % decolourization was observed at 2 g/L catalyst concentration, pH = 6, and 10 ppm dye concentration in 50 min irradiation time at 0.19 mg/L/min rate of decolourization. The initial degradation was confirmed based on chemical oxygen demand (COD) reduction; 89.25 % COD removal at a 0.17 mg/L/min rate was observed. The confirmation of degradation was carried out with UV-visible spectrophotometer and high-performance thin-layer chromatography (HPTLC) analysis. AgNPs were the efficient catalyst for the degradation of RhB. The toxicity study proved that, after degradation of RhB with AgNPs, the degraded products were less toxic than the original ones.
Arsenic uptake and accumulation in plants
Authors: Barhai Akan , Das Suchismita
Published: June 2023

Arsenic uptake by plants is species-specific and its level in terrestrial plants of uncontaminated sites ranged from 0.009 to 1.5 mg/kg. Plants with high metal or metalloid uptake capability in their biomass are called hyperaccumulators. The most efficient arsenic (As) hyperaccumulator belongs to Pteridaceae with species Pteris vittata L. and Pityrogramma calomelanos L., both species can accumulate more than 8000 mg/kg As in their above-ground parts. Higher concentrations of As can interfere with various metabolic activities and manifest through several morphological impairments. A higher concentration of As accelerates the production of free radicals and reactive oxygen species (ROS) within the cell. Plants have a scavenging system to regulate the production of ROS; the scavenging system is also known as the antioxidant defence system. The defence mechanism consists of both an enzymatic and non-enzymatic antioxidant system. Non-enzymatic antioxidant includes carotenoids, ascorbic acid, and glutathione whereas the enzymatic antioxidant system comprises superoxide dismutase, catalase, ascorbate peroxidase, guaiacol peroxidase, and glutathione reductase.
Informing Sustainable Energy Policy in Developing Countries: An Assessment of Decarbonization Pathways in Colombia Using Open Energy System Optimization Modelling
Authors: Plazas-Niño Fernando , Yeganyan Rudolf , Cannone Carla , Howells Mark , Quirós-Tortós Jairo
Published: June 2023

In this study, we assess plausible decarbonization pathways in Colombia using an open-source national energy system optimization model (OSeMOSYS). We build three scenarios over 2021-2050 and contrast them in terms of emissions, energy consumption, technology deployment, costs, and benefits. The results show that a decarbonized energy system can reduce carbon intensity by 93%, energy intensity by 44%, fossil fuel imports by 90%, and provide socioeconomic benefits equivalent to 21% of the Colombia's 2021 GDP. We use these results to recommend milestones and policy actions that can help inform policymakers about cost-effective strategies to achieve a sustainable, efficient, and more resilient energy system by mid-century. Our transparent and systematic methodology provides a tool for long-term energy planning in Colombia which can also be replicated in other developing countries for assessing decarbonization pathways.
An algebraic non-equilibrium turbulence model of the high Reynolds number transition region
Authors: Basse Nils
Published: June 2023

We present a mixing length based algebraic turbulence model calibrated to pipe flow; the main purpose of the model is to capture the increasing turbulence production-to-dissipation ratio observed in connection with the high Reynolds number transition region. The model includes the mixing length description by Gersten and Herwig which takes the observed variation of the von Kármán number with Reynolds number into account. Pipe wall roughness effects are included in the model. Results are presented for area-averaged (integral) quantities which can be used both as a self-contained model and as initial inlet boundary conditions for computational fluid dynamics simulations.
T-junction Configuration Performance in aTransmission Sub-system
Authors: Fahmi Hakim Muhammad , Hermawan Ahmad , Ridzki Imron , Setya Wiwaha Sigit , Azizah Nurjannah Hamka Putri Gadis
Published: June 2023

A cement factory, namely PT Semen Imasco Asiatic, requires a large supply of power for production. However, in the area where the cement factory was established, namely Puger District, there was no electricity capable of supplying it, so PLN built the Puger substation. In the original plan, the transmission line will be built directly from GI Tanggul to GI Puger. However, because the plant must operate immediately, the electricity supply is taken from the existing Tanggul substation-Jember substation transmission line using the T-Junction configuration. In this paper, an analysis of the power flow of the Paiton-Grati subsystem will be carried out when the power supply from Tanggul Substation to Puger Substation is passed through the T-Junction configuration or when the transmission line is connected from the Tanggul Substation to the Puger Substation directly. The result of this research is that there is no significant difference between the two conditions in power losses, voltage drop, current, and power factor parameter so that the T-Junction configuration is quite feasible to use even though it is temporary.
Monopole Antenna Design Analysis for TNI AD Satellite Telecommunication
Authors: Rohadi Erfan , Arga Yoda Vincensius , Datumaya Wahyudi Sumari Arwin
Published: June 2023

Antenna that is made dynamically, light and cheap are the characteristics of microstrip antenna. Microstrip antennas have the characteristics of working at high frequencies according to the antenna calculations if the dimensions are small, the working frequency becomes high frequency. So the monopole microstrip antenna is the solution to the existing military communications. This research will study a monopole antenna design with small dimensions using parameters in millimeters (mm). This antenna works at a working frequency of 3.73 GHz. The substrate used has a size of 99.53 mm x 84.35 mm with a thickness of 0.787 mm, = 4.4×10−12F·m−1 and an impedance of 50 . Antenna performance can be seen from the value of Return Loss, Bandwidth, VSWR, and Radiation Pattern of the antenna. The simulation result data is presented using the WIPL-D software based on the Method of Moment. This indicates that at 3.73 GHz the highest gain value is 5.4 dB, VSWR 1.46 with a bandwidth of 10.18% and a return loss of -14.44 dB. This result is sufficient to meet the satellite communication in the coverage area of ​​the C Band which works in the frequency range of 3-4 Ghz.
Chemical and Sensory Characteristics of Clover (Marsilea crenata) Powder Infusion with the Addition of Red Ginger (Zingiber officinale)
Authors: Linda Mei Velina  , Lia Amalia  , Muhammad Fakih Kurniawan
Published: June 2023

Clover (Marsilea crenata) has the potential to be used as powder infusion products because its benefits to health. The disadvantage of clover leaf is it produce an unpleasant aroma that requires the addition of spices. This study aims to study the effect of clover powder  formulations and red ginger (Zingiber officinale) spice on the chemical and sensory characteristics of herbal infusion. This study used Completely Randomized Design (CRD), namely the comparison of Clover leaf powder and red ginger powder, namely (95%:5%), (90%:10%), (85%:15%) and (80%:20%). The analysis included moisture content, ash content, antioxidant activity, water soluble extract content as well as sensory quality tests and hedonic tests. The data were analyzed statistically using ANOVA and continued with DNMRT at the 5% level. The addition of red ginger powder had a significant effect on moisture content, ash content, antioxidant activity (IC50), water soluble extract content, and descriptive and hedonic sensory assessment and overall assessment. The selected formula based on the final result is the addition of 80% clover powder and 20% red ginger powder with a water content of 16.68%; ash content 4.71%; antioxidant activity 207.745 ppm; and water-soluble essence content of 19.02%. The sensory quality test of the selected products obtained a brownish-green color, not unpleasant, and a bit spicy. The results of the hedonic test showed that the color, aroma, and taste of powder infusion were preferred by the panellists.
Engineered extracellular vesicles as therapeutics of degenerative orthopedic diseases
Authors: Wei Junyu , Ou Zixuan , Tong Bide , Liao Zhiwei , Yang Cao
Published: June 2023

Degenerative orthopedic diseases, as a global public health problem, have made serious negative impact on patients’ quality of life and socio-economic burden. Traditional treatments, including chemical drugs and surgical treatments, have obvious side effects and unsatisfactory efficacy. Therefore, biological therapy has become the focus of researches on degenerative orthopedic diseases. Extracellular vesicles (EVs), with superior properties of immunoregulatory, growth support, and drug delivery capabilities, have emerged as a new cell-free strategy for the treatment of many diseases, including degenerative orthopedic diseases. An increasing number of studies have shown that EVs can be engineered through cargo loading, surface modification, and chemical synthesis to improve efficiency, specificity, and safety. Herein, a comprehensive overview of recent advances in engineering strategies and applications of engineered EVs as well as related researches in degenerative orthopedic diseases, including osteoarthritis (OA), osteoporosis (OP), intervertebral disc degeneration (IDD) and osteonecrosis of the femoral head (ONFH), is provided. In addition, we analyze the potential and challenges of applying engineered EVs to clinical practice.
Intracoronary imaging-guided rotational atherectomy combined with intravascular lithotripsy in the treatment of severe coronary artery calcification—A case report
Authors: Cui Fengwen , Tong Yaliang , Liu Guohui , Zhang Wenqi , Liu Kun , Si Daoyuan , He Yuquan
Published: June 2023

Background

Severe coronary artery calcification increases the difficulty of percutaneous coronary intervention procedures and impairs stent expansion. Herein, we report a case of a patient who was successfully treated with rotational atherectomy using a stepped burr strategy combined with intravascular lithotripsy for plaque modification under intracoronary imaging.

Case summary

A 65 year-old woman presented to our hospital with recurrent chest pain evolving for 1 year. Coronary angiography showed approximately 80% stenosis of the proximal mid-left anterior descending artery. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) revealed a 360° annular calcification. The calcification was rotablated with 1.5 and 1.75 burrs, and the lesion was undilatable with a 3.0 mm non-compliant balloon at 14 atm. Subsequently, the intravascular lithotripsy was reset for the modification of the calcified lesion. A shockwave balloon measuring 3.0 mm × 12 mm was delivered, and 40 pulses were performed at 6 atm. Intravascular imaging modalities (IVUS and OCT) revealed a circumferential calcified plaque with deep fractures. After post-balloon expansion followed by drug-eluting stent placement with a final stent expansion of 84%, there were no intraoperative complications and no major adverse cardiovascular events within 90 days postoperatively.

Conclusion

A combination of rotational atherectomy and intravascular lithotripsy may be an effective and complementary strategy for the treatment of severely calcified lesions that cannot be resolved using a single procedure. However, more clinical studies are required to clarify this finding.
Modeling inter-individual differences in ambulatory-based multimodal signals via metric learning: a case study of personalized well-being estimation of healthcare workers
Authors: Paromita Projna , Mundnich Karel , Nadarajan Amrutha , Booth Brandon M. , Narayanan Shrikanth S. , Chaspari Theodora
Published: June 2023

Introduction

Intelligent ambulatory tracking can assist in the automatic detection of psychological and emotional states relevant to the mental health changes of professionals with high-stakes job responsibilities, such as healthcare workers. However, well-known differences in the variability of ambulatory data across individuals challenge many existing automated approaches seeking to learn a generalizable means of well-being estimation. This paper proposes a novel metric learning technique that improves the accuracy and generalizability of automated well-being estimation by reducing inter-individual variability while preserving the variability pertaining to the behavioral construct.

Methods

The metric learning technique implemented in this paper entails learning a transformed multimodal feature space from pairwise similarity information between (dis)similar samples per participant via a Siamese neural network. Improved accuracy via personalization is further achieved by considering the trait characteristics of each individual as additional input to the metric learning models, as well as individual trait base cluster criteria to group participants followed by training a metric learning model for each group.

Results

The outcomes of the proposed models demonstrate significant improvement over the other inter-individual variability reduction and deep neural baseline methods for stress, anxiety, positive affect, and negative affect.

Discussion

This study lays the foundation for accurate estimation of psychological and emotional states in realistic and ambulatory environments leading to early diagnosis of mental health changes and enabling just-in-time adaptive interventions.
Characterization of thermal infrared medium- and short-term anomaly information from block to fault in mainland China
Authors: Zhang Jingye , Sun Ke , Du Chen , Zhu Junqing
Published: June 2023

The relationship between satellite thermal infrared anomalies and earthquakes or fault activity has been studied for more than 30 years. In this study, five strong earthquakes (the MS6.1 earthquake in Biru, Tibet; the MS7.4 earthquake in Madoi, Qinghai; the MS6.0 earthquake in Delingha, Qinghai; the MS6.1 earthquake in Lushan, Sichuan; and the MS6.8 earthquake in Luding, Sichuan) that occurred on the western mainland of China over the past 2 years were studied. Based on monthly MODIS land surface temperature (LST) data and daily NOAA satellite longwave radiation data, the departure algorithm and the Robust Satellite Techniques (RST) algorithm were used to extract and analyze the characteristics of thermal infrared anomaly information for blocks and faults around the earthquake from different temporal and spatial scales. The results showed the following: 1) In the medium-term scale study based on monthly data, blocks near the epicenters of five earthquakes showed temperature increase anomalies of 1–6 months before the earthquakes; the areas of temperature increase anomalies were clearly controlled by the spatial distribution of the blocks, and earthquakes mostly occurred within blocks with frequent temperature increase anomalies. 2) In the short-term, thermal infrared anomaly feature tracking based on daily data meant that obvious thermal anomalies were also found. The thermal anomalies before the five seismic events all appeared within a period of 3 months before the earthquake, and there were multiple consecutive days of anomalies. The significant temperature increases generally occurred a month before the earthquake, and the distribution of the anomalies was mostly in the form of strips, which is basically consistent with the trend of the fault zone. The use of thermal infrared remote sensing data to summarize the dynamic evolution of thermal infrared anomalies of blocks and faults before strong earthquakes can provide a basis for the long-term monitoring of fault activity and seismic monitoring by satellite thermal infrared technology.
Sensitivity limits for strain detection of hypothetical remote fluid-induced earthquakes (Mw ≥ 4): a case study in Taiwan
Authors: Canitano Alexandre
Published: June 2023

Capturing and quantifying the timing of remotely triggered earthquakes and understanding the physical processes responsible for this delay represent major challenges in earthquake forecasting. In this study, we propose a physical framework for the integration of borehole strainmeter observations for the investigation of remote triggering of moderate to large earthquakes (Mw ≥ 4) in Taiwan. Based on the time-delay computation between regional events and global earthquakes, we establish a selection of earthquakes showing fault zone properties (hydraulic diffusivity and nucleation length) that may be compatible with a magnitude-dependent fluid-induced nucleation process. Using theoretical fault zones parameters, we calculate the evolution of fluid pressure transiting along the nucleation region under the assumption of a one-dimensional, homogeneous poroelastic medium. Pore pressure levels reached before earthquake rupture are ranging from about 0.02 kPa to 3 kPa in the case of teleseismic wave-induced elastic pressure ranging from 0.15 kPa to 27.3 kPa. To compute the time-dependent evolution of deformation generated by a remote diffusing pressure front, we model the nucleation region using the analogue volcano source represented by a horizontal circular crack, and calculate synthetic dilatation at the strainmeter location from displacements using a finite-difference approach. In general, predictions are about two to four orders of magnitude smaller than observations (∼ 10–5 to 10–3 nϵ). Therefore, this suggests that detection of pore pressure-related deformation would have required change of volume in the nucleation region that is at least one order of magnitude larger than for the hypothetical cases considered here. The study represents the first attempt to analyze strain time-series for detecting pre-earthquake strain anomalies related to fluid-induced earthquakes and illustrates the challenge for detecting and characterizing intermediate-to far-field earthquake precursors caused by fluid flow in active regions.
Marrow adipose tissue is increased in overweight and obese women with PCOS independently of hyperandrogenism related obesity and metabolic disorders
Authors: Xu Li , Min Min , Li Xintong , Blake Glen M. , Zhao Kaiping , Ruan Xiangyan , Cheng Xiaoguang
Published: June 2023

Purpose

This study aimed to investigate the increase in bone marrow adipose tissue (BMAT) in overweight and obese women with polycystic ovary syndrome (PCOS) and its relationship with hyperandrogenism, obesity, and metabolic disorders.

Methods

The study included 87 overweight or obese women with PCOS (mean age 29 ± 4 years), as well as 87 age-matched controls recruited from a separate population study. All PCOS patients were measured for anthropometric features, abdominal adipose tissue areas, BMAT, biochemistry, and sex hormones. BMAT was compared between the PCOS patients and controls. In PCOS patients, subgroup comparisons of BMAT and its associations with body adiposity indices, biochemistry, and sex hormones were analyzed. The odds ratios (ORs) of elevated BMAT (defined as BMAT ≥ 38%) were calculated.

Results

On average BMAT was increased by 5.6% ( ± 11.3%) in PCOS patients compared to controls. BMAT were significantly higher in the upper tertiles of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C). BMAT was not correlated with abdominal adiposity indices or biochemistry except for LDL-C (r = 0.253—0.263, p = 0.014—0.018). LDL-C was not significantly different between the normal and abnormal androgen PCOS subgroups (p = 0.10-0.887). LDL-C, follicle stimulating hormone (FSH), and total testosterone (TT) were risk factors for elevated BMAT, with ORs of 1.899 (p = 0.038-0.040), 1.369 (p = 0.030-0.042), and 1.002 (p = 0.040-0.044) for each unit increase, respectively.

Conclusion

BMAT was increased in overweight and obese PCOS patients, but the increase in BMAT was not associated with the hyperandrogenism related obesity or metabolic disorders.
Modeling the systemic trade risk of crude oil from a network perspective, combined with a sentiment proxy
Authors: Chang Hao , Luo Aiguo , Zheng Yilin , Chang Ridong , Liu Yifan
Published: June 2023

Introduction: Trade networks of crude oil are susceptible to cascade of initial shocks that increase systemic trade risks and threaten energy security. This study introduces a novel method of modelling systemic trade risk of crude oil which is combined with a sentiment proxy from a network perspective.

Method: We construct sentiment instability to evaluate the uncertainty of crude oil trade in a country and use the PageRank algorithm to measure supplier diversity from a network perspective instead of direct trade partners.

Result: At the global level, we show that the distribution of systemic oil trade risk has an obvious heterogeneity and a significant negative correlation between systemic trade risk of crude oil and trade volume volatility. At the regional level, we compare the systemic trade risk of crude oil between China and America and systemic trade risks show strongly significant correlations with the price volatility in both China and America. Furthermore, the structure of trade network can effectively reduce the systemic risk in America while it increases the systemic trade risk in China.

Discussion: Our results can give a reason for an irrational practice of Chinese crude oil imports which are “buying when the price is rising and not buying when the price is declining”.
Drought did not change the linear relationship between chlorophyll fluorescence and terrestrial gross primary production under universal biomes
Authors: Jia Liping , He Yi , Liu Wanqing , Li Yanlin , Zhang Yaru
Published: June 2023

Introduction

Satellite observations of sun-induced chlorophyll fluorescence (SIF) are increasingly considered a “probe” for photosynthesis. In recent years the emergence of SIF has facilitated regional and global monitoring of vegetation photosynthesis. On the one hand, there is still controversy about the liner or non-linear SIF-GPP relationship and whether high-temperature events will change the linear relationship. On the other hand, it is unclear whether different vegetation types will affect the SIF-GPP. We used GOSIF and MOD17A2 GPP to study the different relationships under five vegetation types during the long-term climate change period and the extreme drought in 2009/2010 in southwest China.

Methods

In this study, curve fitting was used to explore the relationship of SIF and GPP under long time series and extreme drought period.

Results

We found that during the long-term climate change period, there was a generally linear SIF-GPP relationship under five vegetation types. The correlation is almost universally maintained at the r2 = 0.92 level. During the drought, the extremely high temperature did not change the linear relationship. Besides the farmland ecosystem, the correlation remained at the r2 = 0.85.

Discussion

Our study shows that the linear relationship of SIF-GPP is not influenced by drought on a large scale, and there is a general SIF-GPP relationship in different vegetation types. In the case of extreme drought, irrigation measures adopted by farmers in response to heat conditions may affect the SIF-GPP relationship of farmland.
Construction of a neural network diagnostic model for renal fibrosis and investigation of immune infiltration characteristics
Authors: Guo Yangyang , Cen Kenan , Hong Kai , Mai Yifeng , Jiang Minghui
Published: June 2023

Background

Recently, the incidence rate of renal fibrosis has been increasing worldwide, greatly increasing the burden on society. However, the diagnostic and therapeutic tools available for the disease are insufficient, necessitating the screening of potential biomarkers to predict renal fibrosis.

Methods

Using the Gene Expression Omnibus (GEO) database, we obtained two gene array datasets (GSE76882 and GSE22459) from patients with renal fibrosis and healthy individuals. We identified differentially expressed genes (DEGs) between renal fibrosis and normal tissues and analyzed possible diagnostic biomarkers using machine learning. The diagnostic effect of the candidate markers was evaluated using receiver operating characteristic (ROC) curves and verified their expression using Reverse transcription quantitative polymerase chain reaction (RT-qPCR). The CIBERSORT algorithm was used to determine the proportions of 22 types of immune cells in patients with renal fibrosis, and the correlation between biomarker expression and the proportion of immune cells was studied. Finally, we developed an artificial neural network model of renal fibrosis.

Results

Four candidate genes namely DOCK2, SLC1A3, SOX9 and TARP were identified as biomarkers of renal fibrosis, with the area under the ROC curve (AUC) values higher than 0.75. Next, we verified the expression of these genes by RT-qPCR. Subsequently, we revealed the potential disorder of immune cells in the renal fibrosis group through CIBERSORT analysis and found that immune cells were highly correlated with the expression of candidate markers.

Conclusion

DOCK2, SLC1A3, SOX9, and TARP were identified as potential diagnostic genes for renal fibrosis, and the most relevant immune cells were identified. Our findings provide potential biomarkers for the diagnosis of renal fibrosis.
Single-cell sequencing in primary intraocular tumors: understanding heterogeneity, the microenvironment, and drug resistance
Authors: He Lin-feng , Mou Pei , Yang Chun-hui , Huang Cheng , Shen Ya , Zhang Jin-di , Wei Rui-li
Published: June 2023

Retinoblastoma (RB) and uveal melanoma (UM) are the most common primary intraocular tumors in children and adults, respectively. Despite continued increases in the likelihood of salvaging the eyeball due to advancements in local tumor control, prognosis remains poor once metastasis has occurred. Traditional sequencing technology obtains averaged information from pooled clusters of diverse cells. In contrast, single-cell sequencing (SCS) allows for investigations of tumor biology at the resolution of the individual cell, providing insights into tumor heterogeneity, microenvironmental properties, and cellular genomic mutations. SCS is a powerful tool that can help identify new biomarkers for diagnosis and targeted therapy, which may in turn greatly improve tumor management. In this review, we focus on the application of SCS for evaluating heterogeneity, microenvironmental characteristics, and drug resistance in patients with RB and UM.
Case Report: High-dose immunoglobulins prior to plasma exchange in severe pulmonary renal syndrome
Authors: Schäfer Ann-Kathrin , Dierks Sascha , Schnelle Moritz , Korsten Peter , Hakroush Samy , Tampe Björn
Published: June 2023

Plasma exchange rapidly depletes pathogenic anti-neutrophil cytoplasmic autoantibodies (ANCAs) and is considered for induction therapy in severe ANCA-associated vasculitis. The aim of plasma exchange is to remove putative disease mediators from the circulation, such as toxic macromolecules and pathogenic ANCAs. To our knowledge, we here provide the first report of applying high-dose IVIGs prior to plasma exchange and assessment of ANCA autoantibody elimination in a patient with severe pulmonary renal syndrome due to ANCA-associated vasculitis. After high-dose application of intravenous immunoglobulins (IVIGs) prior to plasma exchange treatment, efficacy of myeloperoxidase (MPO)-ANCA autoantibody elimination was substantially increased, associated with rapid clearance of MPO-ANCA autoantibodies. High-dose IVIGs resulted in marked reduction of MPO-ANCA autoantibody levels and did not directly affect autoantibody clearance by plasma exchange itself, as also confirmed by comparable MPO-ANCAs in the exchange fluid relative to serum levels. Moreover, measurements of serum creatinine and albuminuria confirmed that high-dose IVIGs were well tolerated and did not exacerbate kidney injury.