bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids
Authors: Müllner Markus , Yang Kylie , Kaur Amandeep , New Elizabeth J.
Published: June 2018

Molecular polymer brushes allow for independent tailoring of nanoparticle design parameters. Brush particles with altered shape and aspect ratio revealed that particle shape effects may be decoupled from surface chemistry to achieve higher tumour spheroid interaction and penetration.
A type of thiophene-bridged silica aerogel with a high adsorption capacity for organic solvents and oil pollutants
Authors: Liu Yuetao , Sun Jiawen , Yuan Junguo , Wang Shuai , Ding Yu , Wu Yumin , Gao Chuanhui
Published: June 2018

Thiophene-bridged silica aerogel was prepared from tetraethyl orthosilicate (TEOS) and 2,5-divinyltrimethoxysilanethiophene (DVTHP) through a facile sol–gel reaction and ambient pressure drying process.
A Zn(OTf)2 catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles with indole-derived ketimines: rapid access to hexacyclic spiroindolines
Authors: Liu Yun-Lin , Mao Xiang-Yu , Lin Xiao-Tong , Chen Guo-Shu
Published: June 2018

A Zn(OTf)2 catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles and indole-derived ketimines was developed for the synthesis of hexacyclic spiroindolines featuring three stereocenters including two quaternary stereocenters.
Lactamization of sp2 C–H bonds with CO2 under transition-metal-free and redox-neutral conditions: a computational mechanistic study
Authors: Li Weiyi , Li Caiqin , Lyu Yajing
Published: June 2018

Bases play the primary role in Stages (I) and (III). CO2 serves as an atomic oxidant [O] acceptor in Stage (II).
A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes
Authors: Huang Jen-Huang , Haffey Kiersten , Arefin Ayesha , Akhadov Leyla E. , Harris Jennifer F. , Iyer Rashi , Nath Pulak
Published: June 2018

A unique microfluidic platform to rapidly and accurately measure the bulging heights of polymeric membranes.
Optical constants acquisition and phase change properties of Ge2Sb2Te5 thin films based on spectroscopy
Authors: Xu Zemin , Chen Chaonan , Wang Zhewei , Wu Ke , Chong Haining , Ye Hui
Published: June 2018

The refractive index and extinction coefficient of Ge2Sb2Te5 chalcogenide films can be subtly tuned with post-treatment processes.
Effects of H2 and N2 treatment for B2H6 dosing process on TiN surfaces during atomic layer deposition: an ab initio study
Authors: Park Hwanyeol , Lee Sungwoo , Kim Ho Jun , Woo Daekwang , Park Se Jun , Kim Kangsoo , Yoon Euijoon , Lee Gun-Do
Published: June 2018

Our results showed the effects of H2 and N2 treatment on TiN surfaces, using density functional theory calculations. These imply that the understanding of gas treatment gives us insight into improving the W ALD process for future memory devices.
Engineering substrate promiscuity in 2,4-dichlorophenol hydroxylase byin silicodesign
Authors: Wang Ye , Zhang Chengkai , An Song , Fang Xuexun , Yu Dahai
Published: June 2018

In silicodesigned 2,4-DCP hydroxylase exhibits broader substrate promiscuity for chlorophenols than that of the wild-type enzyme.
Chiral ionic liquids supported on natural sporopollenin microcapsules
Authors: Palazzo Ivan , Mezzetta Andrea , Guazzelli Lorenzo , Sartini Stefania , Pomelli Christian Silvio , Parker Wallace O. , Chiappe Cinzia
Published: June 2018

An access to new chemically modified sporopollenins has been investigated. In a straightforward manner, chiral ionic liquids have been anchored on the surface of the sporopollenin.
Heterocorroles: corrole analogues containing heteroatom(s) in the core or at a meso-position
Authors: Umasekhar Booruga , Shetti Vijayendra S. , Ravikanth Mangalampalli
Published: June 2018

This review article presents an overview of the progress in heterocorrole chemistry including their syntheses, key structural aspects and properties.
The physiological responses of terrestrial cyanobacteriumNostoc flagelliformeto different intensities of ultraviolet-B radiation
Authors: Shen Shi-gang , Jia Shi-ru , Yan Rong-rong , Wu Yi-kai , Wang Hui-yan , Lin Ya-hui , Zhao Dong-xue , Tan Zhi-lei , Lv He-xin , Han Pei-pei
Published: June 2018

The findings would improve the understanding of physiological responses ofN. flagelliformeto UV-B radiation.
Thermal molecular focusing: tunable cross effect of phoresis and light-driven hydrodynamic focusing
Authors: Fukuyama Tatsuya , Nakama Sho , Maeda Yusuke T.
Published: June 2018

A moving temperature gradient controls molecular transport with frequency-tunable hydrodynamic focusing in a polymer solution.
Self-assembly and surface behaviour of pure and mixed zwitterionic amphiphiles in a deep eutectic solvent
Authors: Sanchez-Fernandez A. , Moody G. L. , Murfin L. C. , Arnold T. , Jackson A. J. , King S. M. , Lewis S. E. , Edler K. J.
Published: June 2018

Deep eutectic solvents provide suitable environment for zwitterionic moieties.
Electrostatic interactions between charged dielectric particles in an electrolyte solution: constant potential boundary conditions
Authors: Derbenev Ivan N. , Filippov Anatoly V. , Stace Anthony J. , Besley Elena
Published: June 2018

The problem of electrostatic interactions between colloidal particles in an electrolyte solution has been solved within the Debye–Hückel approximation using the boundary condition of constant potential.
Formation of Ti–Fe mixed sulfide nanoboxes for enhanced electrocatalytic oxygen evolution
Authors: Nai Jianwei , Lu Yan , Yu Xin-Yao
Published: June 2018

Crystalline Ti–Fe mixed sulfide nanoboxes are fabricated and demonstrate enhanced electrocatalytic activity and excellent stability for the oxygen evolution reaction.
Hierarchically structured Co3O4@carbon porous fibers derived from electrospun ZIF-67/PAN nanofibers as anodes for lithium ion batteries
Authors: Zhang Chuan-Ling , Lu Bing-Rong , Cao Fu-Hu , Yu Zhi-Long , Cong Huai-Ping , Yu Shu-Hong
Published: June 2018

Hollow Co3O4 nanoparticle decorated porous carbon fibers with hierarchical structure and enhanced electrochemical performance have been facilely prepared by electrospinning.
Electrochemical n-type doping of carbon nanotube films by using supramolecular electrolytes
Authors: Nonoguchi Yoshiyuki , Kojiyama Keita , Kawai Tsuyoshi
Published: June 2018

This paper describes a rational electrochemical method for selecting appropriate supramolecular dopants that convert p-type SWNTs to their n-type forms.
Maximising the hydrogen evolution activity in organic photocatalysts by co-polymerisation
Authors: Sprick Reiner Sebastian , Aitchison Catherine M. , Berardo Enrico , Turcani Lukas , Wilbraham Liam , Alston Ben M. , Jelfs Kim E. , Zwijnenburg Martijn A. , Cooper Andrew I.
Published: June 2018

The hydrogen evolution activity of a polymeric photocatalyst was maximised by co-polymerisation, using both experimental and computational screening for a family of 1,4-phenylene/2,5-thiophene co-polymers.
Tumor targeting dual stimuli responsive controllable release nanoplatform based on DNA-conjugated reduced graphene oxide for chemo-photothermal synergetic cancer therapy
Authors: Jiang Wenjing , Mo Fan , Lin Yaohui , Wang Xusheng , Xu LiangJun , Fu FengFu
Published: June 2018

A tumor targeting dual stimuli responsive controllable release drug delivery nanoplatform was fabricated for chemo-photothermal synergetic cancer therapy based on DNA-conjugated reduced graphene oxide.
Injection-molded microcellular PLA/graphite nanocomposites with dramatically enhanced mechanical and electrical properties for ultra-efficient EMI shielding applications
Authors: Wang Guilong , Zhao Guoqun , Wang Sai , Zhang Lei , Park Chul B.
Published: June 2018

Lightweight and strong microcellular PLA/graphite nanocomposites with ultra-efficient EMI shielding performance were prepared using mold-opening foam injection molding.
Dual-emission and thermochromic luminescence alkaline earth metal coordination polymers and their blend films with polyvinylidene fluoride for detecting nitrobenzene vapor
Authors: Zhai Lu , Yang Zhu-Xi , Zhang Wen-Wei , Zuo Jing-Lin , Ren Xiao-Ming
Published: June 2018

A facile and effective approach is proposed for fabricating dual-emission luminescent blend films used as dual signal transducer for nitrobenzene vapor detection with excellent performances.
CsPbX3 (X = Br, I) perovskite quantum dot embedded low-melting phosphosilicate glasses: controllable crystallization, thermal stability and tunable emissions
Authors: Chen Daqin , Yuan Shuo , Chen Xiao , Li Junni , Mao Qinan , Li Xinyue , Zhong Jiasong
Published: June 2018

CsPbX3 (X = Br, I) QD embedded glasses are fabricated via a glass crystallization strategy, exhibiting tunable luminescence and superior thermal stability.
Long non-coding RNA HOTTIP promotes prostate cancer cells proliferation and migration by sponging miR-216a-5p
Authors: Yang Bin , Gao Ge , Wang Zhixin , Sun Daju , Wei Xin , Ma Yanan , Ding Youpeng
Published: June 2018

Long non-coding RNAs (lncRNAs) are a class of ncRNAs with >200 nts in length that regulate gene expression. The HOXA transcript at the distal tip (HOTTIP) lncRNA plays an important role in carcinogenesis, however, the underlying role of HOTTIP in prostate cancer (PCa) remains unknown. The aim of the present study was to evaluate the expression and function of HOTTIP in PCa. In the present study, we analyzed HOTTIP expression levels of 86 PCa patients in tumor and adjacent normal tissue by real-time quantitative PCR (qPCR). Knockdown or overexpression of HOTTIP was performed to explore its roles in cell proliferation, migration, invasion, and cell cycle. Furthermore, bioinformatics online programs predicted and luciferase reporter assay were used to validate the association of HOTTIP and miR-216a-5p in PCa cells. Our results found that HOTTIP was up-regulated in human primary PCa tissues with lymph node metastasis. Knockdown of HOTTIP inhibited PCa cell proliferation, migration, and invasion. Overexpression of HOTTIP promoted cell proliferation, migration, and invasion of PCa cells. Bioinformatics online programs predicted that HOTTIP sponge miR-216a-5p at 3′-UTR with complementary binding sites, which was validated using luciferase reporter assay. HOTTIP could negatively regulate the expression of miR-216a-5p in PCa cells. Above all, the knockdown of HOTTIP could represent a rational therapeutic strategy for PCa.
Single‐ended voltage‐mode duobinary transmitter with feedback time reduced parallel precoder
Authors: Ko H. , Chae J.‐H. , Kim S.
Published: June 2018

A duobinary transmitter (TX) is presented in a single‐ended topology using voltage‐mode drivers to support dynamic random access memory (DRAM) interface. A four‐phase parallel duobinary precoder is included. It relaxes one of the critical timing requirements of the duobinary TX by reducing the feedback step of the precoder and performing its feedback at once. Fabricated in a 55 nm CMOS process, the TX occupies 0.053 mm2 active area. The TX achieves 10 Gbps operation at 6.8 pJ/b of energy efficiency and operates up to 12.8 Gbps at 7.6 pJ/b.
Optimum multiplierless compensators for sharpened cascaded‐integrator‐comb decimation filters
Authors: Dudarin A. , Molnar G. , Vucic M.
Published: June 2018

Folding band sharpening of the cascaded‐integrator‐comb filter results in a high passband droop. In applications requiring low passband deviation, the droop is reduced by connecting a low‐order FIR compensator in cascade with the filter. In this Letter, the authors present a method for optimum design of compensators whose coefficients are expressed as sums of signed‐power‐of‐two terms. The method is based on the minimisation of passband deviation, with specified total number of terms.
Modulation of electronic conductivity and bandgap of electrochemically polymerised polycarbazole films using montmorillonite, multi‐walled carbon nanotube and reduced graphene oxide as nanofillers
Authors: Srivastava Aditi , Chakrabarti P.
Published: June 2018

The effect of adding several nanofillers such as montmorillonite (nanoclay), multi‐walled carbon nanotube (MWCNT) and reduced graphene oxide on electrical and optical properties of polycarbazole (PCz) has been experimentally characterised. Polymerisation and deposition of PCz‐based nanocomposite films on Indium Tin Oxide (ITO) coated glass substrate were performed using electrochemical method. Different nanocomposite films were characterised with respect of morphology, bandgap, and conductivity. The effect of nanofillers on the electrical characteristics of Al/PCz Schottky diodes was subsequently studied with devices fabricated in the laboratory. The experimental results demonstrate a radical improvement in the electrical behaviour of the semiconducting polymer after incorporation of nanofillers. It is found from the experimental results that the conductivity is highest and the bandgap is smallest in the case of PCz nanocomposite film using MWCNT as a nanofiller.
Decentralised grid scheduling approach based on multi‐agent reinforcement learning and gossip mechanism
Authors: Wu Jun , Xu Xin
Published: June 2018

As an important class of resource allocation approaches, decentralised job scheduling in large‐scale grids has to deal with the difficulties in acquiring timely model information and improving performance by autonomous coordination. In this study, a gossip‐based reinforcement learning (GRL) method is proposed for decentralised job scheduling in grids. In the GRL method, a decentralised scheduling architecture based on multi‐agent reinforcement learning is presented to improve the scalability and adaptability of job scheduling. A gossip mechanism is designed to realise autonomous coordination among the decentralised schedulers. Simulation results show that the proposed GRL‐based schedulers can complete the task of grid job scheduling effectively and achieve load balancing efficiently.
Stable stitching method for stereoscopic panoramic video
Authors: Tan Zhuo , Zhang Shenghao , Wang Ronggang
Published: June 2018

This paper proposes a stable method of generating a stereoscopic panoramic video with the omnidirectional stereo (ODS) format. Different from the traditional image stitching method which can only be applied to generate a monocular panorama, we adopt an optical flow‐based blending method to create two panoramas for binocular vision. In addition, traditional image stitching methods based on seam‐finding tend to cause the problem of temporal flicker. We address this problem by restricting the optical flow field of the new frame with its previous frame's optical flow field. Thus, the generated video is stable and out of temporal flicker. There are four key operations in our approach. First, we adopt the ODS format which is the basis of stereoscopic panorama. Second, we do effective exposure compensation, making the brightness of the two eyes' panoramas consistent. Third, we employ an optical flow‐based blending method to synthesis the final panorama effectively. Fourth, we take the previous frame's optical flow field as the restriction of the present frame's optical flow field to acquire a stable video. The final output videos can deliver a pleasant and impressive stereoscopic viewing experience to the audience when the audience watches the videos in the virtual reality headset.
Adaptive tracking control of flapping wing micro‐air vehicles with averaging theory
Authors: Qian Chen , Fang Yongchun
Published: June 2018

An input constrained adaptive tracking controller is designed for flapping micro aerial vehicles, wherein the moving averaging filter is adopted to estimate the averaged states of the system. Specifically, in the outer loop controller, an observer is constructed to estimate the disturbances within the system. Moreover, the constrained thrust is designed to keep the frequency in a proper region so as to meet the requirement of average estimation. Then, a tracking differentiator is used to provide trackable trajectories for the inner loop. Subsequently, a new quaternion‐based hybrid attitude tracking controller is designed which successfully deals with high‐frequency noises and avoids possible chattering. As supported by mathematical analysis, the proposed control strategy guarantees the uniform ultimate boundedness of the closed‐loop system, and it keeps the control torques within the permitted range to meet the application requirement. At last, numerical simulations are carried out to support the validity of the proposed controller, whose results are satisfactory even when the thrust and torques are saturated.
Wind and nebula of the M 33 variable GR 290 (WR/LBV)
Authors: Maryeva Olga , Koenigsberger Gloria , Egorov Oleg , Rossi Corinne , Polcaro Vito Francesco , Calabresi Massimo , Viotti Roberto F.
Published: June 2018

Context. GR 290 (M 33/V532 = Romano’s Star) is a suspected post-luminous blue variable star located in M 33 galaxy that shows a rare Wolf–Rayet (WR) spectrum during its minimum light phase. In spite of many studies, its atmospheric structure, its circumstellar environment, and its place in the general context of massive stars’ evolution is poorly known.

Aims. We present a detailed study of this star’s wind and mass loss, and a study of the circumstellar environment associated to the star.

Methods. Long-slit spectra of GR 290 were obtained during its present minimum luminosity phase with the Gran Telescopio Canarias covering the ∼3600–7500 Å wavelength range together with contemporaneous photometry using B, V, R and I filters. The data were compared with non-local thermodynamical equilibrium (non-LTE) model atmosphere synthetic spectra computed with CMFGEN code and with models for ionized interstellar medium regions computed with CLOUDY code.

Results. The current mV = 18.8 mag is the faintest at which this source has ever been observed. The non-LTE models indicate effective temperatures of Teff = 27 000–30 000 K at radius R2/3 = 27−21 R⊙ and mass-loss rate Ṁ = 1.5 × 10−5 M⊙yr−1. The terminal wind speed v∞ = 620 km s−1 is faster than ever before recorded, while the current luminosity L* = (3.1–3.7) × 105L⊙ is the lowest ever deduced. The star is overabundant in He and N and underabundant in C and O. It is surrounded by an unresolved compact H II region with dimensions ≤4 pc, from where H-Balmer, He I lines, and [O III] and [N II] are detected. In addition, we find emission from a more extended interstellar medium (ISM) region, which appears to be asymmetric, with a larger extent to the east (16–40 pc) than to the west.

Conclusions. In the present long lasting visual minimum, GR 290 is in a lower bolometric luminosity state with higher mass-loss rate. The nearby nebular emission seems to suggest that the star has undergone significant mass loss over the past 104–105 yr and is nearing the end stages of its evolution.
Infrared nebulae around bright massive stars as indicators for binary interactions
Authors: Bodensteiner J. , Baade D. , Greiner J. , Langer N.
Published: June 2018

Context. Recent studies show that more than 70% of massive stars do not evolve as effectively single stars, but as members of interacting binary systems. The evolution of these stars is thus strongly altered compared to similar but isolated objects.

Aims. We investigate the occurrence of parsec-scale mid-infrared nebulae around early-type stars. If they exist over a wide range of stellar properties, one possible overarching explanation is non-conservative mass transfer in binary interactions, or stellar mergers.

Methods. For ∼3850 stars (all OBA stars in the Bright Star Catalogue (BSC), Be stars, BeXRBs, and Be+sdO systems), we visually inspect WISE 22 μm images. Based on nebular shape and relative position, we distinguish five categories: offset bow shocks structurally aligned with the stellar space velocity, unaligned offset bow shocks, and centered, unresolved, and not classified nebulae.

Results. In the BSC, we find that 28%, 13%, and 0.4% of all O, B, and A stars, respectively, possess associated infrared (IR) nebulae. Additionally, 34/234 Be stars, 4/72 BeXRBs, and 3/17 Be+sdO systems are associated with IR nebulae.

Conclusions. Aligned or unaligned bow shocks result from high relative velocities between star and interstellar medium (ISM) that are dominated by the star or the ISM, respectively. About 13% of the centered nebulae could be bow shocks seen head- or tail-on. For the rest, the data disfavor explanations as remains of parental disks, supernova remnants of a previous companion, and dust production in stellar winds. The existence of centered nebulae also at high Galactic latitudes strongly limits the global risk of coincidental alignments with condensations in the ISM. Mass loss during binary evolution seems a viable mechanism for the formation of at least some of these nebulae. In total, about 29% of the IR nebulae (2% of all OBA stars in the BSC) may find their explanation in the context of binary evolution.
Supporting farmers’ management of change towards agroecological practices by focusing on their work: a contribution of ergonomics
Authors: Chizallet Marie , Barcellini Flore , Prost Lorène
Published: June 2018

The public authorities and some agricultural actors wish to develop agroecology to meet the rise of new challenges (impacts of agricultural practices on natural resources in particular). New agricultural work systems are therefore being designed, and are raising questions about the inclusion of farmers’ work in the agroecological transition. Our research-action endeavours to support the development of farmers’ change management. To do so, we implement a reflective tool: the “chronicle of change”, which appears to be an interesting way to initiate an “enabling intervention in change management” with farmers, and to better understand their work system.
Construire des savoir-faire perceptifs en apnée
Authors: Schirrer Mary
Published: June 2018

Progresser en apnée suppose notamment d’apprendre à écouter les signes subtils ou violents envoyés par le corps. Cette recherche analyse les difficultés et stratégies des pratiquants et entraîneurs pour s’approprier ce corps vivant qui réagit et s’adapte à l’environnement aquatique et au stress généré par la situation d’apnée. Le cadre théorique est celui de la phénoménologie et de l’anthropologie sensorielle. La démarche est ethnographique. L’enjeu de l’article est double. D’une part rendre compte de l’activité d’apnéistes ordinaires à partir d’observations participantes. Il s’agit d’identifier comment ils apprennent à ressentir et à se repérer parmi cette diversité de sensations corporelles qui émergent de la situation d’apnée ; quelles techniques et quelles procédures favorisent la construction de savoir-faire perceptifs relatifs aux sensations corporelles. D’autre part présenter et analyser une méthode de réflexivité en action initiée par un entraîneur afin de co-construire, avec l’athlète, une échelle esthésiologique, en caractérisant les indices significatifs pour le sujet engagé dans son apnée, ainsi qu’une stratégie permettant de dépasser des blocages éventuels. Finalement, ce travail invite à révéler les savoir-faire et l’expertise d’acteurs engagés sur le terrain afin d’améliorer certains processus perceptifs, au service de performances améliorées et/ou d’une meilleure gestion de son capital corporel.
Assessment: Quality of Life Profi le for Spinal Disorders (QLPSD) – Deutsche Version – Lebensqualität von Menschen mit Skoliose erheben
Authors: Kroggel Lena , Kraus Laurent
Published: June 2018

Viele Menschen mit einer Skoliose sind in ihrer Beweglichkeit eingeschränkt und haben Schmerzen. Meist leidet auch ihre Lebensqualität. Die subjektive Sicht der Betroffenen lässt sich mit dem QLPSD erfassen.
Mycoplasmen-assoziierte Haut- und Schleimhautveränderungen
Authors: Blau K. , Abraham S. , Heyne S. , Hägele B. , Bauer A. , Proske U. , Beissert S. , Günther C.
Published: June 2018

Im Zusammenhang mit einer Mycoplasma pneumoniae-Infektion können erosive Haut- und Schleimhautveränderungen auftreten. Diese wurden als Erythema multiforme, Steven-Johnson-Syndrom oder toxische epidermale Nekrolyse beschrieben.

In den meisten Fällen dominiert eine ausgeprägte Mukositis, wohingegen die Hautveränderungen des restlichen Integuments meist nur sehr spärlich auftreten und als atypische Kokarden beschrieben werden.

Einige Autoren postulieren ein eigenständiges dermatologisches Krankheitsbild, das durch Mycoplasma pneumoniae induziert wird und vordergründig zu einer Mukositis mit diskreter Beteiligung der Haut und Augen führen kann.

Wir stellen zwei Kasuistiken vor, welche im Rahmen einer nachgewiesenen MP-Pneumonie ausgeprägte Hautveränderungen aufwiesen, die nicht eindeutig einem Erythema multiforme oder Steven-Johnson-Syndrom zugeordnet werden konnten. Beide Patienten gaben an, initial Erkältungssymptome bemerkt zu haben, welche auch medikamentös behandelt wurden, sodass auch eine Medikamentennebenwirkung nicht ausgeschlossen werden konnte.

Unter der Therapie mit systemischen Kortikosteroiden, Antibiotika bei Nachweis von MP und intensiver Lokaltherapie zeigten sich die Hautveränderungen komplett rückläufig.

Die Beschreibung dieser beiden Fälle fügt sich in die Reihe des neu definierten dermatologischen Krankheitsbildes bei einer Mycoplasma pneumoniae-Infektion.
Pemphigoid gestationis
Authors: Chapsa M. , Heyne S. , Schneiderat S. , Beissert S. , Günther C.
Published: June 2018

Das Pemphigoid gestationis (PG) ist eine seltene und chronische bullöse Autoimmundermatose, die vorwiegend in der 2. Schwangerschaftshälfte oder postpartal auftritt und durch Ausbildung großer, meist erheblich juckender, entzündlicher, erythematöser Infiltrate und Blasen gekennzeichnet ist. Außerhalb der Schwangerschaft wurde die Erkrankung in Assoziation mit trophoblastischen Tumoren (Chorionkarzinom, Blasenmole) beschrieben. Wir berichten über ein Pemphigoid gestationis bei einer 30-jährigen Patientin in der 33. Schwangerschaftswoche ihrer 2. Schwangerschaft. Nach der 1. Schwangerschaft zeigte sich anamnestisch die Erstmanifestation der Erkrankung mit selbstständiger Abheilung. Bei erneuter Exazerbation in der 2. Schwangerschaft erfolgte nach Diagnosestellung die Einleitung einer topischen und systemischen Prednisolontherapie, welche eine zügige Besserung erbrachte.
Funktionelle Anatomie der Emotionsstörungen
Authors: Lotze Martin
Published: June 2018

Wir scheinen uns alle mit Emotionen gut auszukennen, aber dennoch werden in der Emotionsforschung andere Begriffe verwendet, als das beim Laien der Fall ist. Um
das Zusammenspiel der Gehirnareale in der Verarbeitung von Emotionen zu erfassen, ist es zunächst wichtig zu wissen, wie Emotionen unterschieden und
quantifiziert werden.
Psychiatrische Begleiterkrankungen im Rahmen einer Parkinson-Demenz
Authors: Riedl Lina , Fietzek Urban M.
Published: June 2018

Im späteren Verlauf der Parkinson-Krankheit besteht ein hohes Risiko, neben der charakterisierenden motorischen Symptomatik beeinträchtigende kognitive Funktionsstörungen zu entwickeln. Dieser Störungskomplex kann maßgeblich den klinischen Verlauf bei Patienten in fortgeschrittenen Krankheitsstadien bestimmen. Der Artikel umschreibt knapp das pathophysiologische Konzept kognitiver Beeinträchtigungen bei Parkinson. Er benennt relevante Differenzierungen, die Wege zur Diagnose und aktuelle therapeutische Herangehensweisen.
Cardiovascular Effects of Stress During Acutely Increased Free Fatty Acids in a Randomized, Double-Blind, Cross-Over Study in Humans
Authors: Rezaei Safoura , Litschauer Brigitte , Gouya Gazaleh , Baumgartner-Parzer Sabina , Stulnig Thomas , Wolzt Michael
Published: June 2018

Increased free fatty acids stimulate sympathetic nervous system activity, impair endothelium-dependent vasodilation, and increase regional blood flow. The aim of this study was to assess if fatty acids acutely elevated by infusion of intralipid/heparin affect cardiovascular reactivity employing two stressors eliciting either a cardiac (Stroop test) or vascular (Cold Face test) dominated pressor response. Two stress tasks were performed in 20 healthy subjects (10 women, 10 men) before and during a 180-min intralipid/heparin or saline infusion as placebo on alternate trial days in a randomized crossover study design. Blood pressure, heart rate, cardiac index, and total peripheral resistance index were measured. At baseline, the Stroop test did not affect hemodynamic parameters, and the Cold Face test had an impact on hemodynamic parameters except for heart rate. Plasma fatty acids concentrations increased to 810% (t=11.0, p<0.001) of baseline and C-peptide increased by 17% (t=4.66, p<0.001) during intralipid/heparin infusion. This was paralleled by increased cardiac index (F=9.98; p<0.005 vs. saline) and reduced total peripheral resistance index (F=4.46; p<0.05 vs saline). There was no effect of intralipid/heparin or saline infusion on Stroop test or Cold Face test reactivity of hemodynamic parameters. An acute increase in free fatty acids does not affect the magnitude or pattern of stress response in healthy volunteers, but primarily alter the underlying cardiovascular tone by decreasing total peripheral resistance index and increasing cardiac index to maintain a constant blood pressure.
Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis
Authors: Yang Jiajia , Han Renfang , Chen Mengya , Yuan Yaping , Hu Xingxing , Ma Yubo , Wu Meng , Zhang Xu , Wang Mengmeng , Jiang Shanqun , Pan Faming
Published: June 2018

The associations between PvuII (T>C) and XbaI (A>G) polymorphisms of estrogen receptor alpha (ESR1) gene with type 2 diabetes mellitus (T2DM) or metabolic syndrome (MetS) are reported in many studies, but the results are inconsistent. This present work aims to assess the associations by performing a comprehensive meta-analysis. Relevant studies were searched through several databases. The pooled odd ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of PvuII and XbaI polymorphisms with the risk of T2DM and MetS by using the STATA 14.0 software. Eight studies for T2DM and three articles about MetS were included in this meta-analysis. The overall results indicated that PvuII, rather than XbaI polymorphism, was associated with T2DM (regressive model: OR=0.673, 95% CI=0.550 to 0.823, praw<0.001, pFDR<0.003). The subgroup analysis based on race revealed an association of PvuII polymorphism with the decreased T2DM risk in Chinese population and a relationship between XbaI polymorphism and the reduced T2DM susceptibility in Caucasians. The difference of country may be one source of the heterogeneity for PvuII polymorphism and T2DM. However, neither PvuII nor XbaI polymorphism was related to the risk of MetS. The C allele of PvuII polymorphism presents a protective role in T2DM risk, especially in Chinese people. The G allele of XbaI polymorphism is related to a reduced risk for T2DM in Caucasian population. Nevertheless, neither of PvuII nor XbaI polymorphism is associated with MetS risk.
The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Mansournia Mohammad , Ostadmohammadi Vahidreza , Doosti-Irani Amin , Ghayour-Mobarhan Majid , Ferns Gordon , Akbari Hossein , Ghaderi Amir , Talari Hamid , Asemi Zatollah
Published: June 2018

In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Overall, 33 studies were included in the meta-analyses. Vitamin D supplementation were found to significantly reduce serum high-sensitivity C-reactive protein (hs-CRP) (WMD 0.27; 95% CI, – 0.35, – 0.20; p<0.001) and malondialdehyde (MDA) levels (WMD – 0.43, 95% CI – 0.62, – 0.25, p<0.001) in diabetic patients. In addition, vitamin D supplementation were found to increase markers of nitric oxide (NO) release (WMD 4.33, 95% CI 0.96, 7.70), total serum antioxidant capacity (TAC) (WMD 57.34, 95% CI 33.48, 81.20, p<0.001) and total glutathione (GSH) levels (WMD 82.59, 95% CI 44.37, 120.81, p<0.001). Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO, TAC and GSH levels.
Ischemic Preconditioning Enhances Performance and Erythrocyte Deformability of Responders
Authors: Tomschi Fabian , Niemann David , Bloch Wilhelm , Predel Hans-Georg , Grau Marijke
Published: June 2018

This pilot study aimed to evaluate the differential effects of a remote ischemic preconditioning (rIPC) manoeuvre on performance and red blood cell (RBC) deformability compared to a sham control and a placebo setting. Ten male subjects performed three test settings in a single-blind, crossover, and randomized control design. All settings started with 20 min of rest and were followed by 4 cycles of occlusion/reperfusion consisting of 5 min each. During rIPC and placebo, the cuff pressure was inflated to 200 mmHg and 120 mmHg, respectively. During the sham control setting, 10 mmHg pressure was applied. All tests were followed by a cycle exercise with lactate diagnostics. Power at 2 and 4 mmol/l lactate thresholds were calculated. RBC deformability was measured before and after the respective manoeuvre. Results showed that no effect resulted from any manoeuvre on performance values or RBC deformability. But 6 subjects showed a higher power at the 2 mmol/l threshold, and 5 subjects exerted higher power at the 4 mmol/l threshold when the rIPC manoeuvre preceded the exercise. In these responsive subjects, RBC deformability also improved. Hence, rIPC effects are much influenced by the subjects’ responsiveness, and improved RBC deformability might contribute to enhanced performance in responsive subjects.
Prevention of Thromboplastin-induced Thrombosis in Rabbits by Means of Plasmin
Authors: Storm Ole
Published: June 2018

1. By administration to rabbits of plasmin produced by activation of human plasminogen with human urine activator, fibrinolysis in the blood was obtained without observable side effects.

2. A single injection of plasmin protects the animals from a fatal intra vascular coagulation produced by a subsequent thromboplastin administration. Among the control animals treated with inactive plasmin, ⅔ of the animals died from pulmonary thrombosis or massive intracardial coagulation of the blood.
Metamorphose visqueuse des Plaquettes et Formation du Clou hémostatique
Authors: Hugues Jean
Published: June 2018

L’action locale de trois antihistaminiques sur le développement du clou hémostatique a été étudiée au niveau des vaisseaux microscopiques du mésentère du lapin.

La Téphorine et le Diparcol inhibent le développement du thrombus pla-quettaire; le Multergan est sans action.

L’action antihémostatique des deux premiers antihistaminiques doit être rapprochées de l’entrave qu’ils apportent à la métamorphose visqueuse des plaquettes. Cette dernière parait indispensable à l’agglutination réciproque des thrombocytes extravasés au cours du développement du clou hémostatique.

Par ailleurs, l’action des anticoagulants classiques sur l’élaboration d’un thrombus plaquettaire dépend des doses utilisées.

Les effets différents dont sont responsables les anticoagulants à fortes doses, les antihistaminiques et les anticoagulants à faible dose, permettent de scinder le développement du clou hémostatique en 3 stades successifs: a) l’agglutination — très précoce — des premières plaquettes extravasées aux lèvres du vaisseau, b) la constitution progressive d’un thrombus plaquettaire volumineux mais perméable, c) l’imperméabilisation de ce thrombus.
A “New” Family with Stuart-Prower Deficiency
Authors: Roos J , van Arkel C , Verloop M. C , Jordan F. L. J
Published: June 2018

A description is given of the coagulation disturbances in six patients with a haemorrhagic diathesis due to Stuart-Prower deficiency. Relatives of these patients, if heterozygous for this deficiency, showed no significant haemorrhagic diathesis; in the laboratory, their one-stage “prothrombin” times showed only a slight prolongation. Thromboplastin formation in these relatives was sufficient, but determination of the Stuart-Prower factor revealed lower values. The relatives in question were incapable of giving the same correction of the thromboplastin generation test in their bleeder relatives as normal serum does.

The relation between Stuart-Prower deficiency and Christmas factor is discussed.

One patient is described who combined heterozygotism for Stuart-Prower deficiency with alcaptonuria.

The mode of inheritance of the Stuart-Prower deficiency is discussed.
Agglutination précoce des Plaquettes au cours de la Formation du Clou hémostatique
Authors: Hugues Jean
Published: June 2018

Après section d’un vaisseau microscopique, il se produit un accolement remarquablement rapide de plaquettes à la brêche vasculaire. Cet accolement est visible dans 45% des cas on cours la lère seconde, dans 73% des cas on cours des deux premières secondes.

Les hémorragies prolongées (au delà de 10 minutes) ne sont pas nécessairement liées à un trouble de l’accolement précoce des thrombocytes.

L’action de nombreux facteurs sur la formation du clou hémostatique a été étudiée. Seuls les anticoagulants à forte dose et mieux encore les injections I.V. lentes de thrombine, entravant la fixation rapide des plaquettes.

Le rôle éventuel de processus coagulatifs dans ce phénomène est discuté.
Influence of Dicoumarol Derivatives on Plasma Fibrinolytic System
Authors: Niewiarowska Marta , Wegrzynowicz Zenon
Published: June 2018

The influence of some coumarine derivatives (anticoagulant drugs: pelentan [tromexan], sintrom, marcoumar) on plasma fibrinolytic activity has been investigated. The cases studied included a number of patients with coronary thrombosis treated in long-term anticoagulant therapy and rabbits treated with a single dose of the drug.

The anticoagulants have no significant effect either on fibrinogen or plasminogen level. All of the above mentioned drugs cause a prolongation of the euglobulin fibrinolysis time and an increase of the antiplasmin level. These two changes may be correlated to the prolongation of the prothrombin time.

The authors suggest that the described phenomena may be useful for biological and clinical evaluation of anticoagulant drugs.
The Mechanism of Fibrinolysis Induced by Bacterial Pyrogens
Authors: Deutsch E , Elsner P , Marschner I ,   with the technical assistance of
Published: June 2018

1. The mechanism of the activation of plasmin in blood after intravenous injection of bacterial pyrogens was studied.

2. There was plasmin and an activator present in the spontaneous lytic blood samples. In cases with a high level of plasmin a low amount of plasminogen was found and vice versa.

3. There seem to be two mechanisms of activation. In the most cases the activator has the properties of a fibrinokinase. In the other type a fibrinolysokinase was found.

4. The resistence of the activator against changes in pH and influence of temperature was studied. It was found that the activator was very resistent at acid pH, and, therefore, it shoud be classified as a stable type activator. In addition to this a small amount of a labile type activator seems to be present.

5. Some fibrinolytic activity develops in vitro if the pyrogens are incubated with cell-containing plasma or blood. It is supposed that the leucocytes are involved in the activation mechanism.
Etude de la Recanalisation sous Traitement Anticoagulant des Artères Thrombosées Expérimentalement
Authors: Baeckeland E
Published: June 2018

Nous avons réalisé des thromboses d’artères fémorales superficielles chez le Lapin selon la technique de Wright et Kubik. Un certain nombre de lapins ont été traités par un dérivé du dicoumarol. Nous avons fait une étude histologique approfondie des vaisseaux thromboséd, prélevés 3 à 40 jours après la thrombose. Sous l’influence de la thérapeutique, nous avons constaté une restauration fonctionnelle rapide de l’artère; un processus de fibrinolyse, au cours des premiers jours, est à l’origine de la reperméabilisation.
Comparative Studies of the Fibrinolytic System of Sera of Various Vertebrates
Authors: Niewiarowski Stefan , Latallo Zbigniew
Published: June 2018

1. Comparative studies have been performed on the fibrinolytic system of sera of 18 vertebrates: man, monkey, dog, cat, ox, horse, ram, pig, rabbit, mouse, rat, hamster, guinea-pig, hen, duck, turkey, frog, fish.

2. Spontaneously active plasmin in a considerable amount has been found only in guinea-pig euglobulin.

3. The euglobulins from human, monkey, cat and dog sera can be activated by SK and by SKHP mixture.

4. The euglobulin from hamster, rat, mouse, rabbit, bovine, horse, pig and ram sera can be activated by SKHP but not by SK.

5. The euglobulins of lower vertebrates species cannot be activated by neither SK nor SKHP to any considerable value.

6. The activation of fibrinolytic system runs parallel with the activation of proteolysis in human, bovine and guinea-pig euglobulin.

7. The proactivator activity has been found in the species of human, monkey, dog and cat.

8. Streptokinase activated human plasmin (SKHP) has been inhibited by most of the examined animals sera except of the human, monkey, dog and cat sera.

9. It has been found that in the course of purification bovine plasminogen acquires the ability to be activated by SK. An inhibitor of activation occuring in bovine serum and euglobulin is probably removed by purification of plasminogen.

10. The activation of plasmin in guinea-pig serum has been studied, it was found that spontaneous fibrinolytic activity generates slowly in guinea-pig euglobulin and reaches a maximum after 24 hours. Guinea-pig serum and shortly precipitated euglobulin could be activated by SKHP mixture only.

11. Several possible explanations of the different behaviour of fibrinolytic systems in various animals have been discussed.
Steigerung der endogenen Antithrombokinase-Produktion bei Lungenembolie und Myokardinfarkt
Authors: Kovács Erwin
Published: June 2018

Wir haben über die Gerinnungsverhältnisse bei drei Fällen von Lungenembolie und einem Fall von Myokardinfarkt berichtet, in denen wir eine pathologische Vermehrung endogener Antithrombokinase beobachtet haben. Die im Laufe der thromboembolischen Erkrankung auftretende Vermehrung des Anti-koagulans war während 2 bis 7 Tagen im Blute der Kranken nachweisbar. Bei zwei Kranken traten spontan Blutungen auf. Untersuchungen über die Art-spezifität und einige physiko-chemische Eigenschaften des endogenen Anti-koagulans werden kurz referiert. Außerdem wurden einige Annahmen über mögliche Ursachen der Antikoagulantienvermehrung diskutiert: 1. Die Antithrombokinase entstammt aus nekrotischen Geweben. 2. Die Antithromboplastinämie wird durch Störung im Kompensationsmechanismus (Überkompensation) verursacht. 3. Die Antikoagulantienvermehrung setzt auf Antigenwir-kung ein. Endlich betonten wir die praktische Bedeutung der Antikoagulantienvermehrung.
Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma: The Diagnosis through the “Hartel's Route”
Authors: Casolla Barbara , Candela Serena , Ciacciarelli Antonio , Ciolli Ludovico , Romano Andrea , Acqui Michele , Cox Maria , Sette Giuliano , Orzi Francesco
Published: June 2018

The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma is a systemic malignant disease that localizes in a minority of cases in the central nervous system. We report a case of Garcin syndrome that revealed a diffuse large B cell lymphoma (DLBCL) located in the skull base and in the right kidney. We reached the diagnosis by mean of a nonstandard, mini-invasive, transforamen ovale biopsy of the intracranial lesion (Hartel's route).

The nature of the renal mass was determined ex juvantibus. The patient responded to the polichemotherapy with a complete regression of the intracranial lesion and of the renal mass evaluated by computed tomography and total body positron emission tomography scans. We, therefore, confirmed the DLBCL location in the right kidney. Over 4 years of follow-up, the patient has showed a complete remission of the disease. In this report, we emphasize the importance of biopsy in case of Garcin syndrome.
The Relationship of Assisted Reproductive Technology on Perinatal Outcomes in Triplet Gestations
Authors: Shah Jaimin , Roman Tania , Viteri Oscar , Haidar Ziad , Ontiveros Alejandra , Sibai Baha
Published: June 2018

Objective To assess whether assisted reproductive technology (ART) is associated with increased risk of adverse perinatal outcomes in triplet gestations compared with spontaneous conception.

Study Design Secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. Triplets delivered at ≥ 24 weeks were studied. The primary outcome was the rate of composite neonatal morbidity (CNM) that included one or more of the following: bronchopulmonary dysplasia, respiratory distress syndrome, necrotizing enterocolitis, culture proven sepsis, pneumonia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, or perinatal death.

Results There were 381 triplets (127 women) of which 89 patients conceived via ART and 38 patients spontaneously. Women with ART were more likely to be older, Caucasian, married, nulliparous, have higher level of education, and develop pre-eclampsia. Spontaneously conceived triplets were more likely to delivery at an earlier gestation (31.2 ± 3.5 vs 32.8 ± 2.7 weeks) (p = 0.009) with a lower birth weight (p < 0.001). After adjusting for confounders, no differences were noted in culture proven sepsis, perinatal death, CNM, respiratory distress syndrome, or Apgar score < 7 at 5 minutes. All remaining perinatal outcomes were similar.

Conclusion Triplets conceived by ART had similar perinatal outcomes compared with spontaneously conceived triplets.
Actuación del cirujano ante una parálisis braquial obstétrica en los 2-3 primeros años de edad
Authors: Pradilla Pilar
Published: June 2018

La parálisis braquial obstétrica (PBO) es una grave entidad clínica con muchas cuestiones por resolver. Se desconocen los verdaderos factores de riesgo, y aunque la cirugía nerviosa ha mejorado su técnica y las secuelas se previenen con mayor seguridad que hace unos años, el resultado no es el deseado, pues la incidencia de la enfermedad no ha variado y con la cirugía sigue habiendo un porcentaje alto de fracasos en lesiones extensas o que afecten a la mano. En este artículo, se revisará el tratamiento actual en niños con PBO menores de 2–3 años. Se analizarán las técnicas más actuales como son las transferencias nerviosas, la artroscopia de hombro o el uso de la toxina botulínica.