bluuebunny/crossref_metadata_2025 huggingface dataset:
5. A Possible Way of Approaching the Character in the Theater According to the “Role Sheet”
Authors: Chirilă Călin
Published: April 2023

“Match the deed with the word, and the word with the deed. Take care not to exceed the decency and modesty of nature; because everything that exceeds the measure deviates from the goals of the theater, whose purpose from the very beginning and until today is to present a kind of mirror of nature, to show virtue its true face, pride its icon and every age, every era, the pattern and their seal” (Hamlet’s monologue from the play of the same name by W.Shakespeare).
9. Digital Technologies - The Future Way of Learning in Higher Education
Authors: Aliu Nora , Aliu Vlora , Gashi Modest
Published: April 2023

Digitalization trends have moved forward with accelerated steps, surrounding all spheres of our lives with the provision of light services, faster and less expensive communications, more functions, and a great influence on increasing quality of life. In developed countries, digitization of education is seen as one of the priority goals for achieving sustainable development. Higher education is an essential pillar in developing new knowledge economies for the twenty-first century, and Kosovo national authorities are strategically oriented toward the digitalization of higher education. Digitization includes a wide range of activities ranging from lecturers, group work lectures, and inclusion in individual or group study, and exams as an integral part of the revolutionization of higher education. The period of COVID19 has pushed forward the digitization of education in many countries of the world. In Kosovo, this was the period that established the dividing boundaries between the traditional multi-century teaching eras with the new digital era. This period is also characterized by the challenges faced by teaching and learning in the use of efficient digitized methods. This paper explores the impact of digitization on teaching and learning, specifically in medicine and architecture. Also, this work is intended to offer a model of how digital transformation can be used to build competitive advantages for universities. Based on the condition of the accreditation agency and the standards of the International Society for Technology in Education, we can say that the use of software and artistic methods in teaching processes affects the development and advancement of young people.
The legal framework of on call duty for teleworkers
Authors: MARICA Mihaela
Published: April 2023

Today’s Labour Law acknowledges the importance of flexibility in the individual work relationships by the widescale use of teleworking programs. However, the teleworking phenomenon proliferates in parallel with an opposite trend, by which teleworkers are less protected, as a consequence of the current practices by which they are required to respond work-related calls at any time, wherever they are, and the general standards regulating the working time are ignored. While the European Union states show obvious concern with removing such risks, the practice of the Court of Justice of the European Union, given in its interpretation of the Directive concerning certain aspects in the organization of working time, is extremely important. The present study starts from the analysis of certain points in the content of the Working Time Directive 2003/88 adopted across the European Union with regard to the working time, and goes on to provide an overview of relevant decisions issued by the CJEU on working time, then draws conclusions on the legal framework (juridical regime) of on-call duty in the case of teleworkers.
Using SWAT Model to Estimate the Water Balance of Wadi Al-Mohammadi Basin, Western Iraq
Authors: Al-Kubaisi Mahmood H. D. , Al-Kubaisi Qusai Y. S.
Published: April 2023

Water balance as a technique is considered one of the means that is relied upon in solving significant hydrological problems. The soil and water assessment tool (SWAT) model was used in this study to assess the water balance in the Wadi Al-Mohammadi basin located at the eastern edge of the Western Desert. Digital elevation model, soil data, Land use - Land cover, and climate data represent the most important requirements for the SWAT model's input as a database. The Wadi Al-Mohammadi basin delineation results show the overall drainage area was 2286.8 km2 with seven sub-basins. The trend line of climate data indicates a clear increase in the total rainfall, relative humidity, temperature, and solar radiation from 1990-2020, while the wind speed decreased during the observed period. The average monthly hydrological components (precipitation, actual evapotranspiration, surface runoff, lateral flow, and deep aquifer recharge) representing the basin's water balance are 68.8 mm, 67 mm, 2.03 mm, 0.02 mm, and 0 mm, respectively.
The Use of Information Technology in Investigation: Directions, Problems and Prospects
Authors: Frolov Vyacheslav Vladimirovich
Published: April 2023

A high-quality investigation of a crime is impossible without the use of technical means and achievements in the field of information technology. The object of the research of this scientific article is the use of information technologies in the investigation and disclosure of crimes, the subject is the patterns of this activity. The purpose of the scientific article is to determine the directions of the use of information technologies in the investigation of crimes, their characteristics, as well as to establish the reasons that slow down this process and identify priority tasks, the solution of which will eliminate these obstacles. When determining the directions of using information technologies in the investigation, the author was guided by the components (aspects) of crime investigation activities (cognitive, certifying, organizational). It is noted that the process of integrating information technologies into the investigation of crimes is a complex construction of a digital system of criminal justice, which will optimize the activities of the investigator by increasing the efficiency of working with information. The methodology of the conducted research is determined by its purpose and objectives. It is based on a systematic approach to the study of the use of information technology in the investigation and disclosure of crimes. The research methodology used when writing a scientific article was implemented using the following methods: structural and substantive analysis of scientific papers devoted to the topic of this study; logical (when presenting all the material, formulating conclusions, suggestions and recommendations); comparative legal (criminal procedure legislation, regulatory legal acts) and other research methods.
On the Question of the Specifics of the Investigative Actions with Minors in the Investigation of Crimes
Authors: Gritsaev Sergei Ivanovich , Stepanenko Sergei Grigor'evich , Zhukova Polina Stanislavovna , Chiriev Ilya  Sergeevich
Published: April 2023

The object of the study is the criminal procedural relations that develop during the conduct of investigative actions against minors during the preliminary investigation. The subject of the study is the norms of the Constitution of the Russian Federation, the Code of Criminal Procedure of the Russian Federation, other laws regulating relations related to the production of investigative actions involving minors, as well as theoretical foundations and materials of investigative and judicial practice. The procedural features of the interrogation, confrontation, identification, verification of testimony on the spot and other investigative actions with the participation of minors are considered. At the same time, special attention is paid to the use of video recording of their conduct and the involvement of a psychologist or teacher to participate in the investigative action against a minor. The authors note that Federal Law No. 432-FZ of December 28, 2013 has significantly expanded the range of investigative actions involving minors, during which it is necessary to comply with special legal regulations that protect the rights and interests of these persons. The conducted research made it possible to identify some shortcomings in the regulation of investigative actions against minors. The authors propose ways to eliminate them: video filming as a means of fixation should be carried out during all investigative actions involving minors; situations of participation of a psychologist or (and) a teacher, and in some cases a psychiatrist in the production of investigative actions with this category of persons are determined.
Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study
Authors: Srinivas Sahana M , Dhar Sandipan , Gowdra Aruna , Saha Abhijit , Sundararajan Lakshmi , Geetha Thenral S , Banerjee Raghubir , Malakar Rajib , Sil Amrita , Lakshminarayana Shyam Prasad Arakali
Published: April 2023

Background

Filaggrin (FLG) gene encoding the protein filaggrin plays an important role in barrier function of the skin and its alteration is a predisposing factor for atopic dermatitis. FLG gene variants result in absent or decreased filaggrin protein. Worldwide, the prevalence of FLG variants ranges from 14 to 56%. FLG null variants are distinct in each population.

Objectives

To study the FLG gene polymorphisms in Indian children and attempt a genotype-phenotype correlation in atopic dermatitis.

Methods

This was a cross-sectional, multicentre study conducted on 75 Indian children. Demographic details, clinical features and identified FLG null variants were recorded. We performed a whole gene sequencing of the entire FLG coding region using next-generation sequencing technology.

Results

The prevalence of FLG null variants was 34.7%. A total of 20 different FLG loss of function variants in 26 children were documented. Sixteen (80%) variants were novel and four (20%) were previously reported in Asian and European populations. We found a statistically significant association between FLG variants with early age of onset of atopic dermatitis (P = 0.016) and elevated serum IgE levels (P = 0.051). There was no significant difference between atopic dermatitis phenotypes in children having one variant as compared to children harbouring two or more null variants.

Limitation

Small sample size.

Conclusion

Our study reports a unique set of FLG variants different from Asian and European populations, with these variants being significantly associated with an early age of onset of atopic dermatitis and elevated serum IgE levels.
A Roadmap for Achieving Scalable, Safe, and Low-cost Direct Air Carbon Capture and Storage
Authors: Küng Lukas , Aeschlimann Silvan , Charalambous Charithea , McIlwaine Fergus , Young John , Shannon Noah , Strassel Karen , Maesano Cara , Kahsar Rudy , Pike Daniel , van der Spek Mijndert , Garcia Susana
Published: April 2023

Direct air carbon capture and storage (DACCS) involves a set of approaches for capturing CO2 directly from the air and its subsequent long-term storage. DACCS is at an early stage of technical development and currently faces a variety of challenges, including high cost and energy requirements. Building on publicly available data, this paper provides: (i) an overview and classification of DACCS systems, (ii) a harmonization of technical and economic performance of direct air capture technologies, (iii) a comprehensive list of technical- and infrastructure-based obstacles to scaling DACCS systems, and (iv) a roadmap and list of priority initiatives for research, development, demonstration, and deployment of DACCS. Our intent is to drive progress against high-impact priority actions, with a focus on accelerating research, development, and deployment of safe, scalable, and low cost DACCS as a component of the broader carbon dioxide removal portfolio.
Elucidating Trivalent Ion Adsorption at Floating Carboxylic Acid Monolayers: Charge Reversal or Water Reorganization?
Authors: Nayak Srikanth , Kumal Raju R. , Lee Seung Eun , Uysal Ahmet
Published: April 2023

We study trivalent neodymium adsorption on floating arachidic acid films at the air/water interface by two complementary surface specific probes, sum frequency generation (SFG) spectroscopy and X-ray fluorescence near total reflection (XFNTR). In the absence of background ions, neodymium ions compensate the surface charge of the arachidic acid film at 50 µM bulk concentration without any charge reversal. Increasing the bulk concentration to 1 mM does not change the neodymium surface coverage but affects the interfacial water structure significantly. In the presence of a high concentration of NaCl there is overcharging at 1mM of Nd3+ i.e., 30% more Nd3+ than needed to compensate the surface charge. These results show that the total coverage of neodymium ions is not enough to describe the complete picture at the interface, and interfacial water and ion coverage needs to be considered together to understand more complex ion adsorption and transport processes.
On the Automatic Optimization of Lipid Models in the Martini Force Field using SwarmCG
Authors: Empereur-mot Charly , Pedersen Kasper B. , Capelli Riccardo , Crippa Martina , Caruso Cristina , Perrone Mattia , Souza Paulo C.T. , Marrink Siewert J. , Pavan Giovanni M.
Published: April 2023

After two decades of continued development of the Martini coarse-grained force field (CG FF), further refining the already rather accurate Martini lipid models has become a demanding task that could benefit from integrative data-driven methods. Automatic approaches are increasingly used in the development of accurate molecular models, but they typically make use of specifically-designed interaction potentials that transfer poorly to molecular systems or conditions different than those used for model calibration. As a proof of concept here we employ SwarmCG, an automatic multi-objective optimization approach facilitating the development of lipid force fields, to refine specifically the bonded interaction parameters in building blocks of lipid models within the framework of the general Martini CG FF. As targets of the optimization procedure, we employ both experimental observables (top-down references: area per lipid & bilayer thickness) and all-atom molecular dynamics simulations (bottom-up reference), respectively informing on the supra-molecular structure of the lipid bilayer systems and on their sub-molecular dynamics. In our training sets we simulate at different temperatures in the liquid and gel phases up to 11 homogeneous lamellar bilayers, composed of phosphatidylcholine lipids spanning various tail lengths and degrees of (un)saturation. We explore different CG representations of the molecules and evaluate improvements a posteriori using additional simulation temperatures and a portion of the phase diagram of a DOPC/DPPC mixture. Successfully optimizing up to ~80 model parameters within still limited computational budgets, we show that this protocol allows to obtain improved transferable Martini lipid models. In particular, the results of this study demonstrate how a fine tuning of the representation and parameters of the models may improve their accuracy, and how automatic approaches such as SwarmCG may be very useful to this end.
Synthesis and Binding Profile Using Molecular Dynamics of New Building Blocks for PSMA Theranostics and the PSMA617-Cystine-Doxorubicin Therapeutic Bioconjugate Against Prostate Cancer
Authors: Machairas Evangelos , Laros George , Lambrinidis George , Halabalaki Maria , Bouziotis Penelope , Liolios Christos , Kolocouris Antonios
Published: April 2023

GCPII also known as Prostate Specific Membrane Antigen (PSMA), is overexpressed in prostate cancer (PCa) cells and provide a biomarker for tumor targeting PSMA receptor. The development of lysine-urea-glutamate pharmacophore based inhibitors targeting PSMA for theranostics applications led to PSMA11 and PSMA617. In PSMA11, this pharmacophore is attached via aminohexanoic acid (Ahx) spacer to a chelator while in PSMA617 the pharmacophore is connecting with the linker 2-naphthyl-L-Ala, trans-4-(aminomethyl)cyclohexanecarboxylic acid and then to chelator. Here, we synthesized: (a) a squaramide analog of lysine-urea-glutamic acid; (b) two new building blocks for PSMA theranostics in which lysine-urea-glutamic acid was attached with two (i) phenyl alanine residues to target arene binding site of PSMA receptor and (ii) amino hexanoic acid residues. (d) Inspired from the promising structure of PSMA617 we synthesized a new bioconjugate prodrug in which we replaced the chelator in PSMA617 with a cleavable cystine linker attached to the anticancer drug Doxorubicin. Induced fit docking and MD simulations explored the binding profile of the new molecules.
The Correlation of the Terms “Social and Perceptual Images” and “Social Attitudes”
Authors:   Vitebsk State University named after P. M. Masherov, Strelenko A. A. ,   Belarusian State University
Published: April 2023

The article is concerned with the correlation of the concepts “social and perceptual images” and “social attitudes”. The study was aimed at searching for the similarities among the constituents of basic research construct, the correlation between the concepts “social and perceptual images” and “social attitudes”. The study has found that the “social and perceptual images” category includes social attitudes, and the “social attitudes” category contains elements of social and perceptual images. This intersection will be observed in such meta-psychological categories as consciousness and activity. Being fundamental system categories “social and perceptual images” and “social attitudes” may have some effect on other system categories acting as social and perceptual determination.
İşyeri Nezaketsizliğinin Ebelerin Örgütsel Mutluluğuna Etkisi
Authors: AYDIN BEŞEN Meltem , YURDAKUL Mine
Published: April 2023

Amaç: Ebeler, artan iş yükünün yanı sıra mevcut işyeri kültüründen de önemli ölçüde etkilenmektedir. Sağlık işletmelerinde kabalık ve işyerinde şiddetin bir sonucu olarak duygusal iyilik halinin azalması ebelik bakımının kalitesini olumsuz etkileyebilmektedir. Bu araştırmada ebelerin işyerinde algıladıkları nezaketsizlik düzeyi, örgütsel mutluluk düzeyi ve aralarındaki ilişkinin değerlendirilmesi amaçlanmıştır. Yöntem: Araştırma Türkiye genelinde ebe unvanı ile resmi kurumlarda çalışan ve Wep 2 teknolojilerini (WhatsApp, Twitter, Facebook, Instagram) veri toplama formunu dolduracak düzeyde kullanabilen 271 ebe ile yürütülmüştür. Araştırmanın verileri “Tanıtıcı Özellikler Formu” “İşyeri Nezaketsizliği Ölçeği (İNÖ)” ve “Örgütsel Mutluluk Ölçeği (ÖMÖ)” ile toplanmıştır. Tanıtıcı özelliklerin ölçek puanları bakımından farklılıkları için Student t testi ve One Way ANOVA testi kullanılmıştır. Değişkenler arasındaki ilişkiyi belirlemek için Basit Regresyon Analizi yapılmıştır. Bulgular: Araştırmada ebelerin ÖMÖ puan ortalaması 2.86±0.796 ve İNÖ puan ortalaması 2.14±0.918 olarak bulunmuştur. Ebelerin İNÖ puan ortalaması ile ÖMÖ puan ortalaması arasında negatif yönlü, doğrusal bir ilişki tespit edilmiştir (R: -0.494, p<0.001). Sonuç: Bulgularımız ebelerin çalışma ortamında nezaketsizliğe maruz kaldıklarını ve bu durumun örgütsel mutluluğunu olumsuz etkilediğini göstermektedir. Yöneticilerin işyeri nezaketsizliğinin farkında olarak önlem almaları, işyerinde sağlıklı iletişim yollarının geliştirilmesi önerilmektedir.
Rethinking the business process through reengineering
Authors: Hnylianska O.
Published: April 2023

In management, there are many management approaches that make it possible to increase the performance indicators of the enterprise. At the same time, the priority direction of the development of enterprises is the implementation of innovative activities. To achieve success in this area, companies are changing management approaches, organizational structures and business models. However, in the conditions of constant aggravation of the competitive struggle, the achievement of high indicators of the enterprise's activity is best ensured by the reengineering of business processes. The innovativeness of reengineering lies in the fact that it combines the use of the prerogatives of computer technologies, human resource management technologies and changes in business processes. In the current economic conditions, the speed of reaction of all subsystems of the enterprise and the efficiency of operations are of particular importance and are a necessary condition for its effective functioning in the conditions of constantly intensifying competition. In this situation, reengineering is the most effective, because it contributes to increasing the efficiency of the enterprise by changing the business model it uses. Therefore, the study of reengineering procedures, its principles and tasks is relevant in today's conditions. The purpose of the study is to generalize theoretical approaches to the main principles, types and tasks of business process reengineering as a tool for effective enterprise management. The methodological basis of the study was the work of domestic and foreign scientists on the problems of reengineering and change management of enterprises. Business process reengineering is a thorough rethinking and radical redesign of business processes of enterprises that want to significantly improve their performance. . It is used when it is necessary to make a reasoned decision about the reorganization of activities: radical transformations, business restructuring, replacement of existing management structures with new ones, etc. Thanks to the effective use of business process reengineering tools, it is possible to make the enterprise more flexible to changes in the external environment and more stable in competitive conditions. Thus, the reengineering of business processes involves a decisive, fundamental restructuring of business processes and the foundations of the management organization in order to significantly increase the competitiveness of the enterprise on the market and significantly increase the efficiency of the enterprise as a whole system.
Target orientations of the development of state policy for the sustainable development of the "green" economy in Ukraine
Authors: Bilovitska Y.
Published: April 2023

The purpose of the article is to determine the target guidelines for the state policy of sustainable development of the "green" economy in Ukraine. The article uses general scientific and special research methods, the use of which contributed to the solution of the problem in the process of obtaining theoretical and practical results. When studying literary sources, the monographic method was used. The study of concepts, developments, approaches in order to generalize the results of scientific developments of domestic and foreign researchers to solve the problems of formation and implementation of the state policy for the sustainable development of the "green" economy, the method of systematization was used. The methods of classification, induction and deduction were used to determine the targets to which the state policy of sustainable development of the "green" economy should be directed. The abstract-logical method is used for theoretical generalizations and the formation of conclusions. It is proved that the complexity of the problem of formation and implementation of the state policy for the sustainable development of the "green" economy provides for the use of a long-term strategic approach, which will harmoniously integrate such a policy into the public administration system of Ukraine, which is in the process of reforming and adapting to European legislation, which is supported by a number of international obligations. It has been determined that the goal of state policy is to stabilize and improve the state of the environment of Ukraine in order to create an environmentally friendly natural environment for the life and health of the population, the introduction of an ecologically balanced system of nature management and the conservation of natural ecosystems, which are important for all life on planet Earth. The article proposes the Conceptual provisions for the development of a strategy for the state policy of sustainable development of the "green" economy in Ukraine, providing for a gradual move away from the traditional economy (with its areas of activity that are not energy and resource efficient and pollute the environment) to the "green" economy (which is based on qualitative structural shifts, innovative activities and industries that do not harm the environment, efficient use of natural resources, etc.).
Активні та пасивні стратегії управління економічною безпекою суб’єктів господарювання в умовах традиційних та інноваційних загроз
Authors: Зачосова Наталія Володимирівна , Коваль Олексій Вікторович , Сафонов Даніїл Віталійович
Published: April 2023

Визначено обставини, у яких вітчизняні суб’єкти господарської діяльності намагаються функціонувати та досягати цілей свого існування. В умовах традиційних і новітніх загроз існує необхідність дослідження підходів до стратегічного безпеко орієнтованого менеджменту, що покликаний забезпечити безперервне функціонування та рентабельну роботу бізнес-структур, незважаючи на вплив викликів зовнішнього та внутрішнього середовища на цей процес. Метою дослідження є встановлення характерних ознак і формотворчих рис активних і пасивних стратегій управління економічною безпекою суб’єктів господарської діяльності, встановлення їх придатності до використання в умовах війни та під час післявоєнного відновлення економіки України. У процесі дослідження використано методи історичного аналізу, контент-аналізу, синтезу, узагальнення та графічної візуалізації. У результаті вдалося отримати набір факторів, які визначають особливості ефективного стратегічного управління економічною безпекою господарських структур, такі як: війна та окупація, поширення тенденцій Індустрій 4.0 та 5.0, мінливість державної економічної політики, конвергенція з країнами ЄС, глобальна пандемія COVID-19 та її наслідки, BANI World як зовнішнє середовище функціонування підприємств, установ, організацій. Виявлено характеристики активних і пасивних стратегій управління економічною безпекою на мікрорівні. Визначено їх відмінні риси та зроблено висновок, що найбільш ефективною стратегією управління економічною безпекою для підприємств України в умовах повномасштабної війни може стати стратегія, яка поєднає окремі характеристики активних і пасивних стратегій, тобто стратегія змішаного типу, що поміж іншого характеризуватиметься адаптивністю, гнучкістю, інтеграцією з генеральною стратегією та кадровою політикою суб’єкта господарювання.
Recognition of the human right to a healthy environment as customary international law
Authors:   , James Vanessa
Published: April 2023

This thesis proposes an approach that will allow the human right to a healthy environment to be recognised as customary international law. The right has widespread and representative acceptance, and proponents of the right have set out a pathway for its eventual inclusion in the Universal Declaration of Human Rights. However, the right is not yet enshrined in any international human rights treaty or recognised as customary international law. The analysis of evidence in this thesis establishes that the right exists as a rule of customary international law, meeting the criteria for one constituent element of customary international law, but there is insufficient evidence to demonstrate that the content of the right is a general practice of states, the other constituent element of customary international law. This thesis demonstrates that the right can meet the criteria for recognition as customary international law if the UN Sustainable Development Goals (SDGs) are used as evidence that the content of the right to a healthy environment is a general practice of states. This thesis establishes the connection between the SDGs, which are human rights affirming measures, and the right to a healthy environment by demonstrating that all aspects of the right are connected to the SDGs. The analysis in this thesis also shows that the SDGs meet the criteria for a general practice as required for customary international law.
PENGARUH VARIASI KONSENTRASI HPMC TERHADAP KUALITAS MUTU SEDIAAN FACIAL WASH GEL NANOPERAK HASIL BIOSINTESIS EKSTRAK BUAH PEPAYA (Carica papaya L.)
Authors: Hasriyani Hasriyani , Presticasari Hardiyani , P Novam Danu , Mundriyastutik Yayuk
Published: April 2023

AbstrakBuah pepaya (Carica papaya L.) mengandung banyak senyawa flavonoid yang dapat mensintesis perak menjadi nanoperak. AgNP (nanoperak) diketahui memiliki aktivitas sebagai antibakteri pada jerawat. AgNP kemudian diformulasikan ke dalam sediaan Facial Wash gel dengan 3 variasi konsentrasi HPMC kemudian dilakukan uji mutu sediaan meliputi organoleptis, pH, viskositas, daya sebar, dan daya lekat. Sediaan disimpan selama 14 hari di suhu ruang untuk mengetahui pengaruh dari waktu penyimpanannya.Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variasi HPMC dan mengetahui kualitas mutu dari sediaan facial wash gel nanoperak.Jenis penelitian merupakan penelitian true experimental yang menghasilkan data kualitatif dan kuantitatif. Analisis kualitatif berdasarkan penelitian-penelitian terdahulu yang termuat dalam pustaka dan analisis kuantitatif dilakukan dengan metode statistik Two Way Anova (α = 0.05) serta analisis Post-Hoc dengan uji Tukey. Terdapat pengaruh akibat perbedaan HPMC yang digunakan pada 3 formula yaitu Formula 1 (2% HPMC), Formula 2 (3% HPMC), dan Formula 3 (4% HPMC) terhadap kualitas mutu sediaan berdasarkan uji organoleptis, uji pH, uji viskositas, uji daya sebar, dan uji daya lekat. Pada Formula 1 tidak dapat memenuhi kriteria daya lekat yang baik, sedangkan pada Formula 2 dan 3 memenuhi kriteria syarat sediaan facial wash yang baik.Hasil penelitian menunjukkan bahwa ada hubungan antara pengaruh dari variasi konsentrasi HPMC terhadap kualitas mutu sediaan facial wash gel tetapi pengaruh dari waktu penyimpanan selama 14 hari tidak mempengaruhi kualitas mutu sediaan. Kata Kunci : Carica papaya L., Nanoperak, Facial Wash.
UJI AKTIVITAS ANTIJAMUR SEDIAAN KRIM EKSTRAK ETANOL DAUN CIPLUKAN (Physalis angulata L.) TERHADAP Candida albicans
Authors: Khudzaifi Muhamad , Fadel Muhammad Nurul , Arif Fahrudin , Akhyasin Akhyasin , Retnowati Eko
Published: April 2023

Latar belakang : Penyakit infeksi merupakan salah satu permasalahan yang banyak terjadi di Indonesia. Salah satu infeksi yang banyak ditemukan adalah infeksi yang disebabkan oleh jamur Candida albicans. Kejadian resistensi antijamur telah menjadi permasalahan sehingga diperlukan adanya inovasi baru. Salah satunya dengan pengembangan tanaman obat yang telah diteliti memiliki khasiat sebagai antijamur. Salah satunya adalah tanaman Ciplukan (Physalis angulata L.). Daun ciplukan memiliki kandungan senyawa aktif berupa alkaloid, saponin, tanin, dan flavonoid yang merupakan senyawa aktif biologis sebagai antimikroba. Tujuan : Mengetahui aktivitas antijamur krim ekstrak etanol daun Ciplukan (Physalis angulata L.) terhadap jamur Candida albicans. Metode : Penelitian ini menggunakan difusi cakram dengan konsentrasi yang digunakan yaitu 5%, 10%, dan 15% diletakkan pada media SDA yang telah ditumbuhi oleh jamur Candida albicans yang kemudian akan diinkubasi serta diukur diameter zona hambatnya. Hasil : Pada konsentrasi 5% pada hari ke 1 dan ke 21 didapatkan diameter zona hambat sebesar 15 mm dan 14 mm, konsentrasi 10% mendapatkan hasil pada hari ke 1 18 mm dan hari ke 21 sebesar 15 mm, kemudian konsentrasi 15% pada hari ke 1 dan ke 21 mendapat hasil 20 mm, dan pada kontrol positif didapati hasil 34 mm pada hari ke 1 dan pada hari ke 21 mendapat 33 mm. Kesimpulan : Berdasarkan data diatas dapat disimpulkan bahwa krim ekstrak etanol daun Ciplukan (Physalis angulata L.) dapat menghambat jamur Candida albicans.
Mentoring as an effective form of formation and development of a young teacher's personality
Authors: Malinin V. A. , Povshednaya F. V. , Lebedeva O. V. , Pugachev A. V.
Published: April 2023

Introduction. The proposed article is one of the opportunities to show the need to revive the institution of mentoring (tutoring) in the modern socio-economic conditions of the development of the national education system. Based on the research of scientists, the authors give a description of the main categories of research "mentoring" and "tutoring"; rethink different approaches to understanding their essence. Mentoring is defined by the authors as an effective form of formation and development of the personality of a young teacher.   Materials and Methods. As research methods, the method of analysis and systematization of psychological-pedagogical theoretical-experimental and scientific-methodological studies of domestic scientists on the problem of mentoring, tutoring, support was used.

   Results. The historical and pedagogical analysis of the formation and development of the institute of mentoring in pre-revolutionary Russia, during the Soviet period of the development of the domestic education system and shows the possibilities of the revival of mentoring in modern Russia; the goals and objectives of the "School of Mentoring" in the conditions of the region are defined. The study of the problem of mentoring and tutoring forces a new assessment of their role and importance in the formation and development of the personality of a modern professional teacher, mentor, tutor, who can provide significant assistance in self-determination and adaptation to modern society of each student.   Discussion and Conclusions. The article presents the results of the activity of the "Mentoring School" operating on the basis of the MAOU "School No. 187" of Nizhny Novgorod. Special attention in the activities of the "School of Mentoring" was paid to rethinking the system of methodological work, improving the research and methodological culture of the teacher, developingand implementing methodological support for generalizing the experience of mentoring, which ultimately contributes to the self-development of the teacher's personality, his pedagogical skills and career growth.
The relationship between violence at video games and the consumer’s trait anger and anger expression styles of various variable
Authors: Aslan Mahi , Karayazı Hilal , Saddiki Hatice
Published: April 2023

It can be said that games designed with the theme of violence are the risk factor for the appearance of aggressive attitudes and behaviours. In this case, it has become important to understand the extent of the psychological effects of media contents on consumers.The level of consumption of violent video games in which age range and the level of trait anger-anger style is aimed to reveal.The sample of the study consisted of 286 students. Of the participants, 147 (51.4%) were female and 139 (48.6%) were male. Boys (33.3%;n=39) and high school students (33.7%;n=28) play violent video games more frequently. The level of trait anger was found to be higher in the participants (high school level participants) who played games. The level of outward anger (university level participants) of the game-playing participants were found to be high.
A survey on antimicrobial resistance genes of frequently used probiotic bacteria, 1901 to 2022
Authors: Tóth Adrienn Gréta , Judge Maura Fiona , Nagy Sára Ágnes , Papp Márton , Solymosi Norbert
Published: April 2023

Background

Antimicrobial resistance (AMR) is caused by AMR determinants, mainly genes (ARGs) in the bacterial genome. Bacteriophages, integrative mobile genetic elements (iMGEs) or plasmids can allow ARGs to be exchanged among bacteria by horizontal gene transfer (HGT). Bacteria, including bacteria with ARGs, can be found in food. Thus, it is conceivable that in the gastrointestinal tract, bacteria from the gut flora could take up ARGs from food.

Aim

The study objective was to gain insight into the ARG set carried by commonly used probiotic bacteria that may enter the human body with non-fermented foods, fermented foods, or probiotic dietary supplements (FFPs) and to assess ARG mobility.

Methods

Next generation sequencing whole genome data from 579 isolates of 12 commonly employed probiotic bacterial species were collected from a public repository. Using bioinformatical tools, ARGs were analysed and linkage with mobile genetic elements assessed.

Results

Resistance genes were found in eight bacterial species. The ratios of ARG positive/negative samples per species were: Bifidobacterium animalis (65/0), Lactiplantibacillus plantarum (18/194), Lactobacillus delbrueckii (1/40), Lactobacillus helveticus (2/64), Lactococcus lactis (74/5), Leucoconstoc mesenteroides (4/8), Levilactobacillus brevis (1/46), Streptococcus thermophilus (4/19). In 66% (112/169) of the ARG-positive samples, at least one ARG could be linked to plasmids or iMGEs. No bacteriophage-linked ARGs were found.

Conclusion

The finding of potentially mobile ARGs in probiotic strains for human consumption raises awareness of a possibility of ARG HGT in the gastrointestinal tract. In addition to existing recommendations, screening FFP bacterial strains for ARG content and mobility characteristics might be considered.
Fluid-Bonding and Feelings Condoms: Ambivalent Technologies of Queer Safer Sex
Authors: Barcelos Chris
Published: April 2023

There is an abundance of scholarship on knowledge, behaviors, and attitudes related to safer sex technologies and practices, including a growing body of work that analyses the politics of pre-exposure prophylaxis (PrEP). However, there is comparatively little research that applies a queer feminist science and technology studies lens to safer sex technologies and practices other than condoms and PrEP. This paper draws on archival research and thirty-two in-depth interviews with queer- and trans-identified adults about how they make sense of safer sex practices and technologies, in particular gloves and dams as barriers. I argue that the social world of queer safer sex is marked by ambivalent technologies. For users and non-users, the main affective investment in using gloves and dams is one of ambivalence as they attempt to make sense of their own bodies, relationships, and communities while navigating discourses around risk and sexual health. Ambivalent technologies are also entangled with discourses of risk, governmentality, and community care. Attending to the social worlds of queer safer sex technologies provides insights that are not attainable through behavioral or epidemiological research.
Effects on Fat Mass Through 2 Types of Training
Authors: Mateescu Adriana , Mihaiu Costinel
Published: April 2023

The purpose of this study is that of comparing the effects of aquatic training to the effects of land training, to decrease the fat mass. 24 male students from the UPIT Physical Education and Sport Departament were subjects of the study. The subjects do not practice any performance sport except the loisir sport or the sport exercises from during the faculty hours. The same trainings and testing facilities and methods have been used for each evaluation and each lesson. Each training lasted for 45-70 minutes, 3 days per week. To establish fat mass, we used BIA (bioelectrical impedance analysis) principle. A significant difference of 2.72 has been registered (pre=18.2 and post=15.47) between the two groups with regards to the fat tissue established after the water training programs had ended.
Pelatihan Budidaya Kakao Guna Peningkatan Kapasitas Petani Dan Peningkatan Produksi Kakao Di Aceh Utara
Authors: Nazaruddin Muhammad , Yunus Saifuddin , Baidhawi Baidhawi , Murdani Murdani
Published: April 2023

Cocoa is one of the dominant plantation crops in North Aceh. Matangkuli District is a cocoa development area in North Aceh. The planting area is satisfactory, but the yield and quality are still below the national average. The general objective of this activity is to build and foster a farming community through the cocoa commodity business in order to produce reliable quality human resources. Reliable human resources will be able to manage all the potential of existing natural resources in order to produce quality cocoa bean production, both in terms of production and productivity, so as to create added value and competitiveness according to market needs. In addition, in the long term it is hoped that through this activity it will be able to increase people's income and create jobs and be able to increase the competitiveness of the cocoa value chain by providing more business opportunities in the cocoa plantation sub-sector within the North Aceh Regency area, especially Gampong Ceubrek District. Matangkuli. The focus of the implementation of this service is increasing the capacity of knowledge and skills in managing cocoa gardens and plants, rejuvenating old plants, and improving the quality of crops. During extension activities and field practice, cocoa farmers have been able to practice cocoa maintenance, plant rejuvenation and post-harvest fruit treatment practices. At least the farmer groups will make a pilot demonstration plot to apply maintenance, rejuvenation and post-harvest treatment which will then be compared with the results achieved conventionally. In addition, cocoa farmers are also trained in managing farmer groups. Where the harvest will be concentrated to be given fermentation and drying treatment simultaneously. Marketing will be done collectively, not individually. Collective sales will save on transportation costs, so the sales value received will be higher.
Synthesis of Spherical Structure Graphitic Carbon and Its Characterization
Authors: ATEŞ Fadime , TAHTASAKAL Elif , SEVGİLİ Selin ŞAHİN
Published: April 2023

Sanayi tesisleri, araçlardaki egzoz emisyonu, temizlik malzemeleri gibi alanlardan kaynaklanan sıvı veya gaz, su, hava ve doğal ürünleri kirleten organik veya inorganik kirleticilerin giderilmesine yönelik adsorban geliştirme çalışmaları
son yıllarda önemini sürdürerek devam etmektedir. Bu çalışmada, küresel polimerik aktif karbon (PAK) sentezi ve PAK’ın grafitizayonu ile elde edilen küresel grafitik karbon (GPAK) üretim çalışmaları yapılmıştır. Başlangıçta süspansiyon
polimerizasyonu yöntemiyle polimerik kürecikler sentezlenmiş, sonra 700 °C’ye kadar karbonize edilmiş ve son olarak 830 °C’de su buharı ile aktive edilerek küresel PAK üretimi yapılmıştır. Bu yöntemle üretilen PAK’ın BET cihazı
ile yüzey alanı ve ortalama gözenek çapı ölçüldüğünde sırasıyla 1929,6565 m2/g ve 34,054 Å olduğu tespit edilmiştir. PAK’ın SEM ve RAMAN spektroskopisi ile analizleri yapılmıştır. Tüm bu karakterizasyon çalışmaları sonucunda, PAK’ın
küresel yapılı ve homojen mikro-mezo gözenek dağılımına sahip olduğu tespit edilmiştir. PAK’tan 1750°C’de 6 saatte ve 10 L/dk Argon akış hızında, inert atmosferik basınç ve inert 20 mbar vakum altında grafitizasyon çalışmaları
yapılmıştır. Buna göre vakum altında üretilen GPAK2’nin yüzey alanının (1237,2094 m2/g), atmosferik ortamda yapılan GPAK1’in yüzey alanına (1787,1851 m2/g) göre daha düşük olduğu görülmüştür. 1750 °C’de inert 20 mbar vakum atmosferinde
ve 6 saat grafitizasyon süresinin 10 saate çıkarılması ile beraber yüzey alanının 1231,2380 m2/g’a düştüğü tespit edilmiştir. Ayrıca aynı ürünlerin SEM ve Raman karakterizasyon sonuçlarına göre de GPAK3 ürününün daha düzenli bir
yapı sergilediği ve G bandı genişliği ve yüksekliğine göre daha yüksek grafitizasyona uğradığı tespit edilmiştir
Pengaruh Kadar Aspal Efektif dan Tebal Selimut Aspal Terhadap Proporsi Rongga pada Campuran Laston
Authors: Yuniarti Ratna , Mahendra Made , Hasyim Hasyim , Rohani Rohani , Sideman I A O Suwati
Published: April 2023

In the mixing process between asphalt and aggregate, absorption of asphalt by the aggregate occurs through the pores of the aggregate. The volume of asphalt not absorbed by the aggregate can be defined as effective asphalt content which determines the percentage of airspaces in the compacted mix. The proportion of voids formed in the mixture contributes to the durability of the mixture against temperature and climate conditions. This study aims to examine the effect of effective asphalt content and the asphalt film thickness on the voids proportion in asphalt mixture. Based on the analysis, it can be concluded that the particle size distribution of the aggregate affects the total surface area of the aggregate in the mixture and the pores of the aggregate affect the effective percent of asphalt content. Aggregate with a small grain size produced a larger total surface area of aggregate. Meanwhile the use of aggregate with small pores produced a higher effective percent of asphalt content. The higher the effective asphalt content and the asphalt film thickness, the larger the voids in mineral aggregate and the voids filled with bitumen. In contrast, the voids in the mixture decreases with increase the effective asphalt content and the asphalt film thickness. In all the voids proportions analyzed, the effective asphalt content and the asphalt film thickness have a very significant effect.
O uso do Telegram na aprendizagem de resenha crítica no ensino híbrido
Authors: MARTINS AIRA SUZANA RIBEIRO , Seixas Carla Patrícia Vasconcelos
Published: April 2023

Os modos de comunicação acompanham o desenvolvimento do homem e das tecnologias. As novas ferramentas propiciam o surgimento de novas linguagens e, de modo contínuo, são criadas outras a partir da co
ADAPTAÇÕES BILÍNGUES DAS BIBLIOTECAS DA UFG PARA A PROMOÇÃO DA ACESSIBILIDADE AOS DISCENTES: REFLEXÕES SOBRE A ADEQUAÇÃO DO ACERVO EM PORTUGUÊS ESCRITO PARA A LIBRAS – BIBLIOTECA BILÍNGUE
Authors: Carvalho Andréa dos Guimarães de
Published: April 2023

A partir da constatação da importância da leitura e familiaridade com questões que envolvem a linguística, base de estudos dos cursos para a formação de estudantes surdos via acesso às bibliotecas ins
A IMPORTÂNCIA DO LÚDICO NO PROCESSO DE ENSINO E APRENDIZAGEM.
Authors: Krause Nayara Campos
Published: April 2023

Na infância, a criança apresenta a curiosidade natural de aprender, e a forma como ela aprende precisa estar relacionada com o prazer e com a curiosidade, dois aspectos próprios da infância. Por isso a ludicidade é tão importante como ferramenta metodológica na alfabetização. Por meio dos jogos e brincadeiras, as crianças desenvolvem habilidades que contribuem positivamente para a sua formação. De fato, o brincar se constitui um instrumento elementar da aprendizagem, uma vez que é capaz de despertar a cognitividade e de abrir espaços para a criança expressar seus sentimentos, desenvolver emoções e absorver novos conhecimentos. Nesse sentido, o presente trabalho de conclusão de curso tem por objetivo compreender, a partir dos artigos levantados, as contribuições da prática do lúdico para o processo de ensino e aprendizagem de crianças na alfabetização. Trata-se, portanto, de uma pesquisa bibliográfica. Os principais autores pesquisados são Vieira e Oliveira (2010); Rodrigues (2013); Cardia (2011); Sant’Anna e Nascimento (2011) e Dallabona e Mendes (2004). As conclusões a que chagamos apontam que a prática lúdica é fundamental à educação infantil e que o brincar ajuda a fortalecer o senso de segurança e a autoestima das crianças, ensinando valores e normas sociais.