bluuebunny/crossref_metadata_2025 huggingface dataset:
À perlaboração da violência traumática da repressão: o caso brasileiro
Authors: Rosa Johnny Roberto
Published: June 2020

Resumo No Brasil, o conjunto de medidas administrativas, judiciais, legais, a aplicação de atividades compensatórias, de ações educativas e de políticas de memória assumidas ao acerto de contas com a violência cometida pelos agentes do Estado durante a ditadura civil-militar (1964-1985) levam em conta ações compensatórias, educativas e políticas de memória e verdade agenciadas por meio dos trabalhos da Comissão Especial sobre Mortos e Desaparecidos Políticos, da Comissão de Anistia e da Comissão Nacional da Verdade. Questiona-se aqui a possibilidade de as representações feitas pelas medidas de justiça de transição implementadas pelas comissões de reparação e de verdade assumirem um sentido terapêutico, condicionando a perlaboração dos traumas decorrentes das atrocidades perpetradas pelos agentes da repressão. Para isso, no contexto no qual o Estado brasileiro implementa medidas ao reconhecimento, à reparação, à reconciliação, ao esclarecimento e à responsabilização dos crimes da repressão, submetem-se as narrativas produzidas pelas comissões de reparação e de verdade a uma análise que leva em conta o processo de perlaboração do trauma dessas experiências. Averiguado que as debilidades do processo transicional brasileiro inibem o debate e o engajamento social, dificultam o reconhecimento da violência, colocam obstáculos à simbolização e à apreensão coletiva de suas representações e conduzem os seus termos ao esquecimento ou à revisão, conclui-se que as representações feitas pelas medidas de justiça transicional não condicionam a perlaboração social dos legados traumáticos da violência cometida pelos agentes da repressão durante a ditadura civil-militar no Brasil. Tais condições seguem dificultando que um trabalho de memória da violência da ditadura se configure em um trabalho de perlaboração dos legados de seus traumas.
Por entre as arestas do inquérito: a circulação de informações na prisão e o interrogatório de Henri Pòmpignac, c. 1476-1477
Authors: Fernandes Fabiano
Published: June 2020

RESUMO A multiplicação da capacidade do poder real de levantar informações por meio de um aparato judicial cada vez mais complexo tornava a guerra da fixação de memórias por escrito bastante desigual na segunda metade do século XV. Os príncipes, por mais que se organizassem por meio de ligas, cartas, selos e promessas, estavam diante de um poder real cada vez mais intrusivo, bem informado por espiões e comissionados, economicamente hegemônico e militarmente muito superior. A despeito do esforço de preservação da honra alto-nobiliárquica e da razoável fidelidade demonstrada pelos fiéis de Nemours, a capacidade de produção de verdade jurídica do inquérito extraordinário era algo profundo. Inquirir, comparar, classificar, coagir, moldar percepções eram, em conjunto, uma poderosa arma do poder real.
A Relevância da Transmissão da Pesquisa Científica em Psicanálise para a Graduação
Authors: Silva Isis Graziele da , Bechara Laura Carrasqueira , Hentz Rita Dambros , Pizzimenti Enzo Cléto , Aguiar Gabriela Medeiros Rodrigues
Published: June 2020

Resumo Constata-se, a partir da experiência dos autores enquanto psicólogos recém-graduados por diferentes universidades brasileiras, uma desproporção tanto nas oportunidades oferecidas aos graduandos para que se envolvam com pesquisas quanto no que diz respeito à comunicação daquilo que se produz na pós-graduação. Fazendo uso da metodologia de relato de experiência, objetiva-se refletir de que maneira a interlocução entre ensino e pesquisa contribui para a integração entre a graduação e a pós-graduação. Com isso, pretende-se discutir a inserção da psicanálise enquanto método de pesquisa e de produção de saber na universidade, problematizando a relação entre o campo científico e os psicanalistas que se dedicam à atividade de pesquisa. Uma vez que os programas de pós-graduação e os órgãos de fomento de pesquisa priorizam candidatos que tenham experiência em pesquisa científica a fim de selecionar pesquisadores melhor preparados, é fundamental entender como se dá a transmissão da pesquisa em psicanálise para alunos da graduação. A aposta deste trabalho é que a transmissão da pesquisa acadêmica pode suscitar o interesse e a qualificação necessária nos graduandos para o ingresso na pós-graduação, bem como o desenvolvimento da psicanálise enquanto método de pesquisa acadêmica.
O cotidiano revelado por imagens da cidade
Authors: Gonçalves Monica Villaça , Bezerra Neto Luiz Rafael , Malfitano Ana Paula Serrata
Published: June 2020

Durante uma pesquisa de doutorado, a produção de dados foi realizada em conjunto com os jovens participantes, que narraram sua mobilidade urbana pela cidade do Rio de Janeiro, Brasil. Um desses jovens apresentou, durante o processo, suas fotografias e o desejo de exibi-las, representando os lugares pelos quais circulava na cidade. Elaboramos conjuntamente uma exposição virtual de suas fotografias, nomeada “Cotidiano”. A exposição está disponível on-line e pode ser acessada em diferentes redes sociais. Apresentamos aqui o processo de criação da exposição e as histórias de algumas das imagens que a compõem. A partir deste relato, tendo como foco o processo de pesquisa, buscamos refletir sobre a produção colaborativa de dados e a utilização de atividades significativas para os sujeitos participantes do processo. Acreditamos na implicação do pesquisador no processo de pesquisa e na composição conjunta com seus colaboradores.
Uremic Toxic Blood-Brain Barrier Disruption Mediated by AhR Activation Leads to Cognitive Impairment during Experimental Renal Dysfunction
Authors: Bobot Mickaël , Thomas Laurent , Moyon Anaïs , Fernandez Samantha , McKay Nathalie , Balasse Laure , Garrigue Philippe , Brige Pauline , Chopinet Sophie , Poitevin Stéphane , Cérini Claire , Brunet Philippe , Dignat-George Françoise , Burtey Stéphane , Guillet Benjamin , Hache Guillaume
Published: June 2020

Significance Statement

Uremic toxicity may play a role in the elevated risk of developing cognitive impairment observed in patients with CKD. Some uremic toxins, such as indoxyl sulfate, are agonists of the transcription factor aryl hydrocarbon receptor (AhR). The authors found that cognitive impairment in three models of CKD in rats is correlated with serum levels of indoxyl sulfate as well as blood-brain barrier disruption as detected by SPECT/CT imaging. Using AhR−/− knockout mice, the authors described for the first time that indoxyl sulfate–induced activation of AhR is responsible for blood-brain barrier disruption. These findings demonstrate that blood-brain barrier disruption seems to be an important mechanism involved in cognitive impairment in the context of CKD and that AhR may be a promising therapeutic target to prevent cognitive impairment in CKD.

Background

Uremic toxicity may play a role in the elevated risk of developing cognitive impairment found among patients with CKD. Some uremic toxins, like indoxyl sulfate, are agonists of the transcription factor aryl hydrocarbon receptor (AhR), which is widely expressed in the central nervous system and which we previously identified as the receptor of indoxyl sulfate in endothelial cells.

Methods

To characterize involvement of uremic toxins in cerebral and neurobehavioral abnormalities in three rat models of CKD, we induced CKD in rats by an adenine-rich diet or by 5/6 nephrectomy; we also used AhR−/− knockout mice overloaded with indoxyl sulfate in drinking water. We assessed neurologic deficits by neurobehavioral tests and blood-brain barrier disruption by SPECT/CT imaging after injection of 99mTc-DTPA, an imaging marker of blood-brain barrier permeability.

Results

In CKD rats, we found cognitive impairment in the novel object recognition test, the object location task, and social memory tests and an increase of blood-brain barrier permeability associated with renal dysfunction. We found a significant correlation between 99mTc-DTPA content in brain and both the discrimination index in the novel object recognition test and indoxyl sulfate concentrations in serum. When we added indoxyl sulfate to the drinking water of rats fed an adenine-rich diet, we found an increase in indoxyl sulfate concentrations in serum associated with a stronger impairment in cognition and a higher permeability of the blood-brain barrier. In addition, non-CKD AhR−/− knockout mice were protected against indoxyl sulfate–induced blood-brain barrier disruption and cognitive impairment.

Conclusions

AhR activation by indoxyl sulfate, a uremic toxin, leads to blood-brain barrier disruption associated with cognitive impairment in animal models of CKD.
John Fransham, the Norwich Polytheist: An English Pagan In The Eighteenth Century
Authors: Wheeler Graham John
Published: June 2020

This article seeks to shed new light on an unresolved question in modern religious history: how did classical traditions of paganism come to be revived in modern times in the form of neo-paganism? It seeks to contribute to addressing this question by identifying a hitherto overlooked
individual who embraced revived paganism as a religious philosophy before other, better known figures who have been discussed by previous scholars. The individual in question was the teacher and writer John Fransham (1730–1810). This article seeks to elucidate the main tenets of Fransham's
religious outlook and to locate him within the intellectual context of his time, as both a product of and a rebel against the British Enlightenment. It also publishes his most explicitly pagan piece of writing for the first time.
Anglo-Catholicism in West Wales: Lewis Gilbertson, Llangorwen And Elerch
Authors: Chapman Mark
Published: June 2020

Lewis Gilbertson (1815–1896) was one of the most prominent Anglo-Catholic clergy of St David's' diocese. He became the first incumbent of the new church at Llangorwen just outside Aberystwyth, built by Matthew Davies Williams, eldest brother of the Tractarian poet Isaac Williams
(1802–65). Gilbertson adopted ritualist practices and Tractarian theology, which later influenced the church he was to build in Elerch (also known as Bont Goch) where his father, William Cobb Gilbertson (1768–1854), had built his house in 1818. After a brief survey of the development
of Tractarianism in Wales, the paper discusses the building of the church at Llangorwen, which had the first stone altar since the Reformation in the Diocese of St David's, before discussing Gibertson's ministry in the parish. From Llangorwen Gilbertson moved to Jesus College, Oxford where
he served as vice-principal and where he became increasingly convinced of the need for a new church and parish for his home village. He had earlier built a National School in 1856 commissioning the well-known Gothic revival architect G. E. Street. For St Peter's church, completed in 1868,
he turned to William Butterfield, who had built the Tractarian model church of All Saints', Margaret Street in London. Gilbertson, who appointed himself as first incumbent for a brief period, set the ritualist tone of the parish while at the same time ensuring regular Welsh-language services
to attract villagers from what he called the 'broken shadow of practices of the primitive Church' of the Welsh Methodists. The paper concludes with a brief discussion of Gilbertson's later career before assessing the impact of Tractarianism in west Wales, especially the confident and idealistic
vision of a return to the apostolic faith for all the people of Wales on which it was established.
Employability as a complex problem
Authors: Hernández Corredor Luisa Fernanda , Beltrán Martínez Ronald Sneyder B
Published: June 2020

Introduction:This article is developed within the framework of the Emple-ap project, coordinated since 2018 by the Universidad Distrital Francisco José de Caldas in Bogotá.
Problem:Recent graduates of higher education face a problem of employability that is affected by multiple interdependent and changing variables, actors and contexts, which makes it more complex in nature. However, the problem is usually approached from a simplistic perspective that prevents the construction of proposals that generate a high impact in practice.
Objective: The objective of this research is to generate a proposal to study the problem of employability from the perspective of complex thinking.
Methodology:The methodology used is based on a literature review and a panel of experts through structural analysis.
Results:The predominance of the simplistic approach in the understanding of employability is made evident, being expressed in a limited set of variables and generally focused on the professional. In addition, the structural analysis makes it possible to highlight the high interdependence existing between the variables that encompass different actors and contexts.
Conclusions: It is necessary to redirect the approach from which employability is studied, recognizing that the problem must be tackled globally and is in a state of constant change, in order to generate dynamic solutions that adapt to it.
Originality:This research offers a first proposal to understand employability as a complex problem, emphasizing the interdependence of variables.
Limitations:The presented results are too recent to make a generalization and although the proposed variables were verified in the panel, they have not yet been validated.
Modernización del bioterio de producción del Instituto Nacional de Higiene “Rafael Rangel”
Authors: Moya-Acosta Manuel , Esteves-Guerra Carmen , Sifones-Díaz Freddy , Fernández Rafael
Published: June 2020

Propósito: el uso de animales para investigaciones biomédicas y producción de reactivos, requiere del cumplimiento de estrictas normas internacionales estandarizadas, para garantizar resultados experimentales confiables, reproducibles y comparables. El bioterio de producción del Instituto Nacional de Higiene “Rafael Rangel” (INHRR) presentaba fallas en su infraestructura, con equipos que habían superado su tiempo de vida útil, cuyo mantenimiento deficiente y ausencia de reposición, resultaban en mayor concentración de amoníaco, incremento de la humedad relativa por encima del 70 % y malos olores concomitantes.

Temas: en 2016 se decidió la ejecución de un Plan de Desarrollo de la Planta Física de 1200 m2, con la finalidad de adecuar sus instalaciones mejorar las condiciones sanitarias y optimizar los procesos y flujos a efecto de para garantizar la calidad, cantidad y el manejo adecuado de los animales empleados como sustratos biológicos.

Desarrollo: a partir del estudio y evaluación de posibles alternativas, la edificación fue modificada en su infraestructura, acabados, redistribución de servicios, incorporación de equipos de tecnología de punta, y sistemas de ventilación y bioseguridad, en cumplimiento de las Normas COVENIN e ISO 9001:2015.

Conclusiones: la infraestructura y barreras sanitarias que fueron creadas o modificadas, permiten el flujo unidireccional para el ingreso en áreas limpias y la separación efectiva de estos espacios, con el área de lavado, garantizando mayor seguridad en el núcleo de fundación, de acuerdo con las normas internacionales para la producción de animales de laboratorio. Así, el bioterio pasó de la clasificación microbiológica de Animales Convencionales a la condición de Animales Convencionales controlados con Barreras Sanitarias.
Testosterone boosters: a report of a supplement’s misleading labelling claims
Authors: De Lange Rudi Wynand
Published: June 2020

This paper illustrates how labelling claims of a testosterone booster supplement mislead consumers. The labelling claims misappropriate scientific terminology, exaggerate and misrepresent research as evidence for the product’s purported efficacy.
Trends in HIV pre-exposure prophylaxis uptake in Ontario, Canada, and impact of policy changes: a population-based analysis of projected pharmacy data (2015–2018)
Authors: Tan Darrell H. S. , Dashwood Thomas M. , Wilton James , Kroch Abigail , Gomes Tara , Martins Diana
Published: June 2020

Objectives

HIV pre-exposure prophylaxis (PrEP) is a proven tool for HIV prevention, but PrEP use in Ontario, Canada, and the effects of recent policies are unknown. We estimated the number and characteristics of PrEP users in Ontario and evaluated the impacts of policy changes between July 2015 and June 2018.

Methods

We obtained tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) dispensation data for Ontario from IQVIA, and applied an algorithm to identify use for PrEP. We report prevalent PrEP use for the second quarter of 2018 according to age, sex, region, prescriber specialty, and payer type, and generate “PrEP-to-need ratios” (PNR) by dividing these numbers by the estimated numbers of new HIV diagnoses. We used interventional autoregressive integrated moving average models to examine the impact of three policy changes on PrEP use: Health Canada approval (February 2016), availability of generic TDF/FTC and partial public drug coverage (September 2017), and public drug coverage for individuals aged < 25 years (January 2018).

Results

The estimated number of individuals receiving PrEP increased 713%, from 374 in 2015 Q3 to 3041 in 2018 Q2. Among PrEP users in 2018 Q2, 97.5% were male, 60.4% were < 40 years, 67.7% obtained PrEP from a family physician, 77.2% used private insurance, and 67.0% were in Toronto. PNRs were highest in 30–39-year-olds, males, Toronto and the Central East and West regions. Time series analyses found that Health Canada approval (p = 0.0001) and introducing generics/partial public drug coverage (p = 0.002) led to significantly increased use.

Conclusions

PrEP use has risen in Ontario in association with favourable policy changes, but remains far below guideline recommendations.
Kommunikáció Android okostelefon és Raspberry Pi3-on üzemelő saját MySQL adatbázis között
Authors: Molnár Ádám , Erdei Timotei István
Published: June 2020

Az okostelefonok egyre nagyobb hullámú terjedésének köszönhetően nagyobb igény keletkezik arra, hogy adatainkat saját adatbázisban tároljuk, illetve mindezt mobiltelefonról is elérhetővé tegyük, valamint prezentálható formában tároljuk. Ezen technológia akár nagyvállalati környezetben is könnyen megvalósítható, például adott cégvezetők azonnali, naprakész információt képesek kapni a vállalat jelenlegi állásáról egy Android operációs rendszerrelellátott okostelefonról. Projektünkben egy egyedi-saját tervezésű adatbázis fut egy Raspberry PI 3-as alaplapon működő webszerveren. Az adatbázis és adatai bármilyen Android alapú mobil eszközről - a megfelelő applikáció birtokában - bármikor, bárhonnan interneten keresztül lekérdezhetőek/frissíthetőek/újrekordok helyezhetőek el.
PROPOSALS FOR THE DEVELOPMENT OF RECREATION IN THE SCHEMES OF TERRITORIAL PLANNING ON THE EXAMPLE OF THE PROJECT LYMANSKA AMALGAMATED HROMADA, DONETSKA OBLAST
Authors: Syvak Oksana Olegovna
Published: June 2020

Purpose: The article deals with the perspective development of recreation within the area of Lymanska amalgamated hromada in Donetska Oblast. These perspectives are defined on the materials of the projects of urban planning documentation. The basis for the further effective territorial development is the rational organization of the usage of territorial resources and other ones, as urban planning documentation is a strategic document for further territorial, demographic, economic and environmental development.

Metods: The decision of the tasks was carried out on the basis of generalization and integration of scientific methods, methodology of constructive geography and territorial planning.

Results: There are all opportunities for the development of the recreational sphere at Lymanska amalgamated hromada in consequence of nature-recreational resources. The author considers the boundary loads on the territory, defines the general threshold values of the recreational capacity of the territory for each project recreation areas and the further formation of their infrastructure.

Scientific novelty: analyze the features of the rational use of available resources for the development of recreation at the level of a separate territorial community in the schemes of planning the territory

The practical significance: The materials presented in the article are the basis for the territorial development of the recreational sphere of the Lyman hromada.
MYKOLAIV OBLAST RECREATIONAL POTENTIAL AS A PREMISE OF THE TOURIST BUSSINESS’S DEVELOPMENT IN MYKOLAIV REGION
Authors: Avteniuk Maryna Victorivna , Melnychuk Anatoliy Leonidovych , Melnychuk Anatoliy Leonidovych
Published: June 2020

The main purpose of the article is – on the basis of the research of Mykolaiv oblast recreational potential to define problems and ways of improvement of tourist industry, in particular on the example of Voznesensky district.

Methods. The following research methods were used in the article: cartographic, historical, statistical, literary, analysis method.

Results. The current state of tourist industry of Mykolaiv region and perspectives of tourism development in one of its regions, namely Voznesensky is considered. The tourist object of the district are investigated. A tourist route has been developed.

Scientific novelty. The problems of development of the tourist industry of the region are determined, and also the tourist route has been developed.

Practical significance. The recommendations for the tourist industry of Mykolaiv region and in particular Voznesensky region are given.
Kınalızâde'nin Aile Ahlâkına Bakışı
Authors: GÖZ Kemal
Published: June 2020

Kınalızâde Ali Çelebi ahlâk felsefesi içerikli önemli bir eser kaleme almıştır. Bu eser kendisine ulaşan eserlerin içeriğini geliştirmiştir. İçeriğiyle özgün bir İslâm Ahlâk Felsefesi kaynağıdır. Birinci bölüm ahlâki erdemlerin geniş bir açıklamasını içermektedir. İkinci bölümde aile bireylerinin temel ahlâkî erdemlerle müzehhez olduklarında erdemli birey olarak kendi mutluluklarını elde ettikleri gibi toplumun mutluluğuna da katkı sağladıklarını zikretmektedir. Hayatın her alanının ahlâki alan olarak değerlendirilmesi gerektiğini ortaya koymuş ve bunu eserinde değerlendirmiştir.
Aile söz konusu olunca ailenin mekânı olarak evleri değerlendirmiştir. Evler övünç malzemesi yapılmaması gereken mekânlar olarak değerlendirilmelidir. Kınalızâde ailenin oluşumunda bireylerin erdemli olmasının önemli olduğunu vurgular. Aileleri oluşturan bireyler erdemli olursa toplum da erdemli olur der. Toplumda erdemler yaşam tarzı olarak hayata hâkim olursa mutluluk elde edilir. Bu mutluluk toplumun bütün bireylerini kapsar.
Hikmet, iffet, şecaat ve adalet erdemlerinin bütün alt başlıklarıyla beraber yaşanması biret, aile ve toplumun mutluluğunu sağlayacaktır. Bu erdemler aynı zamanda birlikte yaşama kültürünün gerçekleşmesini de sağlayacaktır. Ailenin yönetiminde de bu erdemler önemlidir. Kınalızâde bu kitaptan yani aile ahlakı kısmından maksadının insanların hallerinin düzene girmesi, hem seçkinlerin hem de avamın dünya ve ahiret hayatının iyileştirilmesi olduğunu ifade etmektedir.
LIGHTWEIGHT NATURAL PUMICE COMPOSITES FOR REHABILITATION OF HISTORICAL BUILDINGS AND LANDSCAPE WORKS
Authors: ÖZODABAŞ Aylin , KARAKURT Cenk
Published: June 2020

Historical buildings are made of
traditional materials such as mud bricks, lime mortars, stone, and wood. Mudbrick is not a durable material against water and compression effects. The aim
of this study is to increase the usage of natural pumice in both mortar and
block production to obtain efficient restoration material in this area. The
specimens obtained by using pumice, slaked lime, tile dust, gypsum and expanded
clay at certain ratios were cured in both steam and laboratory conditions. The
characterization of the raw materials and specimens were carried out by using BET,
XRD, SEM analyses. Also, the physical and mechanical properties of the mortar
and block specimens were determined with laboratory tests. The test results
showed that the highest compressive strength values were obtained from steam
cured specimens. It was observed that the water absorption values ​​of the
specimens which were steam cured slightly better than the naturally cured
specimens.
Preliminary Evaluation of the Antidiarrheal Effects of Ethanol Leaf Extract and Fractions of Rauwolfia vomitoria Afzel. (Apocynaceae)
Authors: Odenigbo Abel , Akah Peter A. , Ilodigwe Emmanuel E. , Ajaghaku Daniel L. , Erhirhie Earnest O. , Ogbonnaya Mba , Ihekwereme Chibueze P.
Published: June 2020

Context: Diarrhea, a major leading cause of death among under-five children in developing countries is still ravaging the society today due to limitations associated with conventional treatment approaches. The leaf of Rauwofia vomitoria (R. vomitoria) is used by the locals in Nigeria for the treatment of diarrhea. Aim: This study evaluated the anti-diarrheal activity of the leaf extract and fractions of R. vomitoria using animal models. Methods: Phytochemical screening of the extract was carried out. The extracts and fractions of R. vomitoria were screened using castor-oil induced diarrhea, castor-oil induced enteropooling, charcoal meal test and ex-vivo anti-spasmomodic models. The tests groups received 400 mg/kg of the extract, n-hexane, ethyl acetate and water fractions based on the result of preliminary study. The Negative control (5 ml/kg of 5% Tween-80) and Positive control (Loperamide, 2 mg/kg and atropine sulphate, 10 mg/kg) were used. Ex-vivo anti-spasmodic test was carried out using isolated guinea pig ileum. Results: Phytochemical test revealed the presence of alkaloids, saponins, tannins, flavonoids, cardiac glycoside, terpenoids and steroids. In castor oil-induced diarrhea model, 400 mg/kg of the extract and fractions significantly (p≤0.05) prolonged diarrhea onset, decreased frequency of defecation, weight of feces, and volume of intestinal content. The extract and n-hexane fraction produced more significant (p<0.05) antidiarrheal activity in castor oil –induced enteropooling and charcoal meal test models. The extract exhibited a dose dependent inhibition of acetylcholine induced contraction of isolated ileum. Conclusion: Results obtained from this study validate the folkloric use of R. vomitoria leaf extract in the treatment of diarrhea.
Role of multidetector computed tomography angiography in evaluation of peripheral arterial disease
Authors: Kumar Rakesh , Taneja Anil
Published: June 2020

Background: Diagnostic imaging plays an important role in the evaluation of peripheral arterial disease. Many imaging modalities are available ranging from conventional modalities to the cross-sectional modalities like Doppler ultrasound, DSA, CT and MRI. The main principles of imaging are to characterize the all lesions detected including type of plaques, no. of lesions, length of stenosis, diameter of vessel in pre-stenotic and post-stenotic segments, degree of wall calcification, assisting in pretreatment planning with respect to route of access, selection of balloon and demonstrates size, extent, neck dimention, and presence of thrombosis in cases with aneurysm.Methods: A Cross-sectional observational study was done in 30 patients. Clinically suspected patients of peripheral arterial disease based on history, sign and symptoms and patients diagnosed with peripheral arterial disease on color doppler were included in our study. Both modalities were compared for detecting the occlusion and stenotic segments.Results: A total of 476 vessel segments were imaged by both modalities. When all arterial segments were considered, MDCTA detected stenosis or occlusion lesions in 30% of arterial segments, versus 18.8% compared to DUS. MDCTA showed 9.8% (95% CI:[4.3%, 15.3%]) more lesions than DUS when all arterial segments were considered together, 11.2% (95% CI: [2.7%, 22.1%]) more lesions when only the iliac arteries were compared, 9.1% (95% CI: [3.2%, 17.2%]) more lesions when only the femoropopliteal arteries were compared, 8.9% (95% CI: [1.5%, 16.3%]) more lesions when only infrapopliteal arteries were compared and 13% (95% CI: [2.6%, 25.4%]) more lesions when only the upper limb arterial segments were compared, (p <0.05 for all comparisons).Conclusions: MDCTA may be used as a screening tool in patients with peripheral arterial disease as it is a non-invasive and more accurate modality when compared to DUS and plays important role in management.
Prospective randomised study of cases of pelvic fracture urethral distraction defects managed by early alignment versus initial suprapubic urinary diversion with delayed urethroplasty
Authors: Kumar Arun , Kaur Gunjeet , Singh Krishna Kant , Pahwa H. S. , Kumar Awanish , Pratap Dhirendra , Agrawal Priyanka
Published: June 2020

Background: In complex pelvic fracture urethral distraction defects (PFUDD), early management prevents incidence of devastating complications such as urinary incontinence, restenosis and urethra cutaneous fistula. The aim of the present study was to study the outcome of patients with PFUDD undergoing early alignment (either by rail roading or endoscopic) compared with initial suprapubic urinary diversion with delayed urethroplasty.Methods: This was a prospective randomized study done at KGMU, Lucknow; having PFUDD during the period from June 2014 to July 2017. Patients with PFUDD were randomized in to two groups. Group A included 22 patients and managed by supra pubic cystostomy followed by delayed urethroplasty. Group B included 23 patients and managed by primary alignment by rail-roading and early endoscopic alignment. Patients were followed up after 6 weeks, 3 months and 6 months for measuring the primary and secondary outcomes during follow up.Results: The most common age group that sustained pelvic fracture urethral distraction defects injury are male of 21-40 years. In group A, stricture was present in all patients at 6 weeks post-surgery. Open urethroplasty was done at 3 months in 60% and 10% patients at 6 months.  In group B, stricture was present in 80% at 6 weeks, 40% at 3 months and 10% at 6 months. The incidence of ED in group A at 6 weeks, 3 months, was 25% patient which reduced to 20% at 6 months. In group B, ED was present in 30% patients 6 weeks, 3 months and which reduced to 25% at 6 months. No incontinence was observed in both groups.Conclusions: Primary realignment has significant benefits compared to SPC as realignment approach is associated with a 50%-55% decrease in stricture formation.
A study on patients with coronary artery disease with special reference to bone mineral density
Authors: Ete Tony , Khan Shakeel Ahamad , Wankhar Baphira , Pala Star , Malviya Amit , Mobing Habung , Naku Narang , Bamon Amethyst , Kumar Utpal , Kumar Arun , Fanai Vanlalmalsawmdawngliana , Pohlong Stephenson , Mishra Animesh
Published: June 2020

Background: Osteoporosis and Coronary artery disease are known to share common risk factors, like inflammation, but a direct relationship between the two has not been established. Some of the previous studies showed low BMD (osteoporosis and/orosteopenia) as an independent predictive factor for coronary artery disease in ambulatory patients. However, some reports have failed to demonstrate a direct relationship between low bone mineral density (BMD) and CAD or cardiovascular risk factors. This study was carried out to estimate bone mineral density (BMD) in patients with coronary artery disease (CAD) and also to evaluate the association between bone mineral density and coronary artery disease.Methods: Hospital based prospective observational study, involving 96 consecutive patients who were referred for coronary angiography for the evaluation of established or suspected CAD and also patients who had acute coronary syndrome (ACS) are enrolled in this study. BMD was determined for the lumbar spine (L2-L4) and femoral neck using DXA scan.Results: The total number of subjects was 96. Out of 96, 24 (25%) patients were females and remaining 72 (75%) were males. Coronary angiography was carried out in all patients. 42 patients from the total had coronary angiography proven single vessel disease (SVD), 33 patients had double vessel disease (DVD) and 21 patients had triple vessel disease (TVD). DXA scan was carried out in all patients. T- score of neck of femur region and lumbar spine was calculated. Neither the presence of significant coronary stenoses ≥50% in two or more coronary vessels nor the prevalence of severe coronary stenoses ≥70% differed significantly between patients with normal bone density, osteopenia, or osteoporosis (p<0.05, respectively).Conclusions: The result of this study suggests that in patients undergoing coronary angiography for the evaluation of CAD, the prevalence of low BMD is high; however, there is no statistically significant relationship between osteoporosis, osteopenia and coronary artery disease state.
Role of common salt in the treatment of umbilical cord granuloma
Authors: Sharma Chandra Madhur , Aggarwal Bindu , Chaudhary Piyush
Published: June 2020

Background: Umbilical granuloma is an overgrowth of granulation tissue following the separation of umbilical cord. Treatment options for this common entity are limited and have side effects such as chemical burns. In this study, we want to highlight the salt application method for treatment of infants with umbilical granuloma.Methods: Thirty six infants were enrolled in present study after institutional ethics committee approval and consent from the parents. After thoroughly explaining the method to all mothers, they are advised to apply a pinch of salt on granuloma twice a day for 3 days .The area of application was cleaned, and common table salt was carefully applied over the lesion. The granuloma was then occluded with surgical adhesive tape for 30 minutes. Cases were followed up after 3 days for assessment of improvement.Results: All thirty six cases responded well to this approach with complete resolution of lesions after 3 days. Small clot like shrunken tissue was found at the site of granuloma, which was easily scraped off during gentle cleansing. No major complication or recurrence was noted in follow-up.Conclusions: The use of common salt in treating umbilical granuloma is simple, cost-effective, curative, and safe. It is easily administered and can be performed by parents at home.
Modelos de cientificidade da gramática em disputa no Brasil no fim do século XIX: a polêmica entre Júlio Ribeiro e Augusto Freire da Silva
Authors: De Aquino José Edicarlos
Published: June 2020

Este artigo trata dos modelos de cientificidade da gramática em disputa no Brasil no fim do século XIX, analisando a polêmica os gramáticos Júlio Ribeiro e Augusto Freire da Silva, que tem como fundamento justamente uma discordância quanto às bases científicas do estudo da linguagem e à definição, divisão e orientação teórica da gramática. Chamando a atenção para a existência de todo um movimento gramatical importante no Brasil a ser considerado além do eixo Rio de Janeiro-São Paulo, mostramos como a gramática geral e a gramática histórica-comparada concorrem como padrão de ciência na produção gramatical brasileira na virada para o século XX, sendo não apenas retomadas, tal como trabalhadas no exterior, mas ressignificadas, num movimento de reivindicação de um trabalho autoral pelos gramáticos brasileiros.
Uma questão glotológica
Authors: Da Silva Jr. Manuel Pacheco
Published: June 2020

Texto sobre a natureza sintática do pronome se.
Strategies for whole-exome sequencing analysis in a case series study of familial male infertility
Authors: Askari Masomeh , Mohammad Kordi Tamandani Dor , Almadani Navid , Totonchi Mehdi
Published: June 2020

Background: Infertility is one of the common health issues around the world. The prevalence of male factor infertility among infertile couples is approximately 30%- 35%, of which genetic factors account for 15%. The family-based whole-exome sequencing (WES) approach can accurately detect novel variants. However, selecting an appropriate sample for data generation using WES has proven to be challenging in familial male infertility studies. The aim of this study was to identify types of pathogenic male infertility in cases of familial asthenozoospermia.
Case: Two families with multiple cases were recruited for the purpose of WES. The study population included two affected cases in pedigree I and three affected cases in pedigree II. Two different variant callers (SAMtools and GATK) with a single-sample calling strategy (SSCS) and a multiple-sample calling strategy (MSCS), were applied to identify variant sites.
Conclusion: In this study, we represented the results for variant prioritization of WES data without sequencing fertile siblings in the same pedigree by applying two different pipelines (homozygosity and linkage-based strategy). Using the aforementioned strategies, we prioritized annotated variants and generated a logical shortlist of private variants for each pedigree.
Key words: Male infertility, Whole-exome sequencing, GATK, SAMtools.
derecho operacional y la cultura de la paz en la institución castrense
Authors: Martín Moreno Luis Antonio
Published: June 2020

En Colombia, las estrictas razones humanitarias aliviaron el horror y los excesos de la violencia hasta lograr la vigencia del Derecho Internacional de los Conflictos Armados (DICA), en un ambiente operacional incierto y complejo. El derecho operacional surge como fortaleza y complemento en las misiones desplegadas por las Fuerzas Militares y la transición hacia la cultura de la paz, cumpliendo con las exigencias de los organismos internacionales en articulación con una noción constructivista para coadyuvar a la reducción de la violencia y legitimar cada vez más los métodos pacíficos como salida al conflicto. Sin embargo, las nuevas amenazas, acompañadas de un sinnúmero de factores de inestabilidad, dificultan su entendimiento y entorpecen la aplicación de los procedimientos operacionales junto al accionar de la fuerza pública. En este sentido, se crea la urgencia de educar mucho mejor a la población castrense en cuanto a la aplicación de las normativas jurídicas nacionales e internacionales para tal fin, pues ni siquiera la teoría del justum bellum ofrece respuestas claras en la justificación de las nuevas formas de conflicto armado.
Herramienta de entrenamiento neuropsicológico para operadores de Aeronaves Remotamente Tripuladas Scan Eagle
Authors: Páez López Gerson Adolfo , Corzo Zamora María Alejandra , Díaz Ariza Alexander , Rodríguez Guerrero Nohora Inés
Published: June 2020

Los eventos de seguridad no deseados en las Aeronaves Remotamente Tripuladas (art) tipo Scan Eagle se han atribuido a los errores humanos, en particular, en latoma de decisiones y los errores durante la operación, los cuales pueden ser susceptibles a mejorar con entrenamiento específico como medida para mitigar el riesgo de accidentes. Este artículo propone una herramienta de entrenamiento basada en el funcionamiento neuropsicológico para los operadores de art en la Fuerza Aérea Colombiana, para el mejoramiento de habilidades y gestión del riesgo, basada en el funcionamiento neuropsicológico y las áreas cerebrales. Se empleó un método de estudio no experimental de corte transversal analítico, realizando monitoreo de la actividad eléctrica cerebral mediante electroencefalografía (EEG) con el equipo B-alert x10, durante misiones reproducidas en simulador de Scan Eagle para identificar las áreas de actividad cerebral en frecuencia beta, y se aplicó  la batería banfe-2 para evaluar funciones ejecutivas y tipo de pensamiento. Se evaluaron 17 operadores masculinos de 28 ± 2,7 años, los resultados fueron analizados según la formación académica de los participantes en experiencia en vuelo, ingenieros y otras formaciones. Se encontró que las seis áreas más utilizadas en la operación de art son las encargadas  de desarrollar habilidad numérica, maniobras que requieren el uso de la mano contraria a la dominante, utilización de la imaginación, lenguaje hablado, razonamiento,  y por último, el área de la percepción tridimensional. Los operadores con experiencia previa en vuelo presentan una actividad cerebral medial y orbital, tienen un pensamiento de tipo automático intuitivo con menor carga cognitiva en el monitoreo electroencefalográfico, mientras que los otros grupos sin experiencia previa en vuelo presentan un pensamiento frontal dorsolateral de pensamiento reflexivo con mayor carga cognitiva. Con los  resultados obtenidos se diseñó una herramienta para el entrenamiento neurocognitivo autónomo y se proponen alternativas adicionales para complementar el entrenamiento de los operadores de art, que permita potencializar el pensamiento automático intuitivo con menor carga cognitiva.
Otra mirada, otra forma de compartir saberes en el aula de matemáticas
Authors: Castellanos Yefferson
Published: June 2020

En este artículo se busca incentivar a los educadores de matemáticas a reflexionar sobre el rol social, político y cultural del quehacer cotidiano en el aula de clase. Para ello, se resaltan la connotación política de la enseñanza de las matemáticas y la perspectiva sociopolítica como otra forma de orientar y compartir saberes. La discusión sobre la connotación política del área de la matemática brinda un panorama de la monocultura del saber, que permea la enseñanza en la escuela regular y convierte el escenario escolar en un reproductor de la cultura hegemónica, el cual determina qué conocimientos enseñar y cuáles no.Luego, se analiza la importancia de enseñar matemáticas desde la pedagogía crítica, puesto que toda acción en el aula es política y tiene incidencia social. Para finalizar, se exploran estrategias pedagógicas para aproximar a educandos y educadores al saber matemático desde una práctica reflexiva y contextual, como estrategia para hacer una matemática cultural.
Caratteristiche di una coorte di pazienti con co-infezione HIV/HCV: i dati dell’Ambulatorio di Malattie Infettive dell’Ospedale San Gerardo di Monza.
Authors: E Colella , al. et
Published: June 2020

Gli ultimi dati epidemiologici indicano un decremento della prevalenza dell’infezione da HCV nella popolazione generale, tendenza apparentemente confermata anche dai dati della Coorte ICONA di pazienti HIV-positivi. Tuttavia, è noto come i dati inerenti alla prevalenza di questa infezione subiscano fluttuazioni talvolta importanti a seconda delle epidemiologie locali.
Abbiamo analizzato le caratteristiche dell’infezione da HCV nella nostra coorte di 1974 pazienti HIV+. La prevalenza dei pazienti co-infetti HIV/HCV è risultata pari al 19% (371 pazienti); di questi, il 79% (294) era di sesso maschile; la nazionalità era italiana nel 94% (348) dei pazienti; il fattore di rischio di maggiore rilievo è risultato essere l’utilizzo di sostanze per via endovenosa (IVDU) (162, 44%). L’età media della popolazione HIV/HCV è risultata essere di 52.8 anni (deviazione standard 8.6). Il 65% (241) dei pazienti aveva HCV-RNA rilevabile alla diagnosi, mentre attualmente, su 262 pazienti HIV/HCV attivamente seguiti il 92% (240) ha raggiunto la risposta virologica sostenuta (SVR).
L’elevata prevalenza di eradicazione in questa popolazione di pazienti co-infetti HIV/HCV potrebbe indicare la micro-eliminazione come possibile approccio gestionale dell’eradicazione dell’infezione da HCV. Resta tuttavia ancora una sfida importante e ambito di miglioramento la retention in care del paziente sia HIV+, che HCV/HCV co-infetto.
Penguatan konsep parenting bagi masyarakat/orang tua murid Raudhatul Athfal Desa Batujai, Praya Barat, Lombok Tengah
Authors: Zohdi Ahmad
Published: June 2020

[Bahasa]: Pola asuh pada tahap awal sangat menentukan sifat, watak dan karakter anak pada masa yang akan datang. Kebanyakan orang tua sering melupakan pola asuh anak, tidak berfikir pentingnya keamanan, kenyamanan, pengaruh sosial, dan lingkungan anak. Kesalahan pola asuh orang tua bagi anak usia dini akan berakibat fatal seperti anak akan mengalami kelemahan mental, pendiam, penakut, keras, brutal, dan sebagainya. Disinilah pentingnya penguatan Konsep Parenting bagi masyarakat khusunya bagi wali murid yang memiliki anak usia dini agar dapat melewati masa kritis dan memanfaatkan masa golden age (usia keemasan) anak usia dini.

Kata Kunci: karakter, parenting, golden age
Pelatihan manajemen organisasi kepemudaan dalam upaya penguatan idealisme kepemudaan guna menangkal paham radikalisme
Authors: Rosyid Bahrur
Published: June 2020

[Bahasa]: Dalam kaidah bahasa Qurani pemuda atau yang disebut “asy-syabab”didefinisikan dalam ungkapan sifat dan sikap seperti: 1). berani merombak dan bertindak revolusioner terhadap tatanan sistem yang rusak, 2). memiliki standar moralitas (iman), berwawasan, bersatu, optimis dan teguh dalam pendirian serta konsisten dalam dengan perkataan, seperti tergambar pada kisah Ash-habul Kahfi (para pemuda penghuni gua. 3). seorang yang tidak berputus-asa, pantang mundur sebelum cita-citanya tercapai. Peran penting dari seorang pemuda adalah pada kemampuannya melakukan perubahan. Perubahan menjadi indikator suatu keberhasilan terhadap sebuah gerakan pemuda. Perubahan menjadi sebuah kata yang memiliki daya magis yang sangat kuat, sehingga membuat gentar orang yang mendengarnya, terutama mereka yang telah merasakan kenikmatan dalam iklim status quo. Tujuan pengabdian pada masyarakat dengan pengambilan tema dalam kegiatan ini adalah Untuk melatih Pemuda dalam meningkatkan Idealismenya guna menangkal Paham Radikalisme dalam sebuah Wadah Organisasi Kepemudaan, untuk Membentuk Wadah Organisasi Kepemudaan dalam hal ini adalah Karang Taruna, sebagai lembaga penghimpun dan menyalurkan bakat dan minat masing-masing pemuda, harapannya supaya pemuda di Lingkungan Gegutu Timur terarah dan tepat menyalurkan minat dan bakatnya, sehingga akan terbentuk idealisme pemudanya secara kuat dan kokoh guna menangkal paham Radikalisme. Kegiatan pemberdayaan  masyarakat ini diharapkan dapat memberikan manfaat di antaranya : Peningkatan pemahaman dan kesadaran Pemuda tentang pemberdayaan diri dengan potensi yang ada melalui Wadah Organisasi Kepemudaan, Dengan adanya Wadah Organisasi Kepemudaan ini dapat menjadi wadah menyalurkan potensi, minat dan bakat berikut mengolalanya tentunya dengan proses pendampingan secara kontinue dan dievaluasi pada ahir kegiatan, sehingga kedepannya akan tercipta rasa aman dan tentram dalam kehidupan bermasyarakat, dengan Pemuda yang punya Inisiatif tinggi untuk melaksankan perubahan, tentunya perubahan ini didasari dengan jiwa kreatif dan inovatif, maka akan terjawab bahwa pemuda merupakan tulang punggung kemajuan dalam kehidupan bermasyarakat, berbangsa dan bernegara.

Kata Kunci: kepemudaan
Pelatihan “Co-Fe (Microsoft Office)” sebagai upaya pembekalan Soft Skill di bidang ilmu komputer bagi pemuda pasca lulus SLTA Desa Keselet, Sakra, Lombok Timur
Authors: Nurman Muhammad
Published: June 2020

[Bahasa]: Tujuan pengabdian ini  untuk membekali ilmu berupa soft skill di bidang komputer terutama menggunakan microsoft office yang dapat menunjang kemampuan masyarakat sehingga mempunyai modal untuk bekerja dan bisa bersaing di dunia kerja. Metode pemecahan masalah yang digunakan dalam kegiatan pengabdian pada masyarakat ini adalah dengan menggunakan metode: ceramah, diskusi dan praktek. Melalui gabungan metode-metode tersebut diharapkan mampu mempraktekan microsoft office. Agar program ini berjalan maksimal, maka diperlukan perencanaan atau persiapan, diantaranya: (a) Survei tempat pelaksanaan kegiatan, (b) Pembuatan proposal dan penyelesaian administrasi perijinan tempat atau lokasi pengabdian masyarakat, (c) Pembuatan modul pelatihan MS Word dan MS Excel, (d) Pembuatan atau pencarian video tutorial MS Word dan MS Excel (d) Perbanyakan modul sesuai dengan jumlah peserta. (e) Penentuan nara sumber. Hasil pelaksanaan kegiatan: (1) Kegiatan Desa Binaan yang dilaksanakan dalam bentuk pelatihan Co-Fe (Microsoft Office) ini dapat terlaksana dengan baik dan lancar, meskipun tidak terlepas pula dari beberapa hambatan dan keterbatasan di lapangan. (2) Warga binaan memiliki keterampilan praktis sehingga menjadi bekal memasuki dunia kerja. (3) Warga binaan atau peserta pelatihan memiliki keterampilan life skill yang dapat dijadikan modal untuk mengikuti persaingan pada era dimana keterampilan dibidang komputer sangat dibutuhkan. (4) Warga binaan atau peserta pelatihan tidak asing lagi dengan istilah-istilah komputer yang mana selama ini mereka beranggapan bahwa komputer itu adalah suatu barang yang aneh bagi mereka dan tidak mungkin mereka dapat mengoperasikannya.

Kata Kunci: pelatihan, soft skill , komputer, Co-Fe (Microsoft Office)