bluuebunny/crossref_metadata_2025 huggingface dataset:
Factores que influyen en la sostenibilidad de los emprendimientos de las madres soltera de Guayaquil
Authors: Jara-Nivelo Jimmy , Macías-Chuto Elizabeth , Orellana-Intriago Carlos
Published: June 2022

El tema del emprendimiento, ha sido en los últimos tiempos, muy visible, permitiendo diseñar normas y leyes en favor de brindarle a los emprendedores el apoyo para el desarrollo de los mismos. No obstante, en Ecuador a pesar de contar con un gran abanico de leyes, se considera que aún queda por hacer, en especial para apoyar el emprendimiento de las madres solteras, las cuales muchas veces, por no tener los conocimientos de cómo mejorar sus competencias o cómo acceder a ayudas financieras, sus emprendimientos mueren al nacer, resolviendo solamente por un momento su situación económica familiar. Por ello, el objetivo de este trabajo es develar a través de la literatura consultadas, los ítems más importantes del emprendimiento de las mujeres solteras en Guayaquil, con el fin de identificar cuáles son los factores que influyen el emprendimiento femenino. Esta revisión bibliográfica permitió identificar las concepciones básicas sobre emprendimiento, los factores para la sustentabilidad de los mismos, la realidad de las mujeres solteras de Guayaquil, así como los decretos y políticas de las diferentes entidades gubernamentales. Logrando al final argumentar que existen grandes avances en esta materia, pero aún falta un camino por recorrer para el triunfo de los emprendimientos femeninos, ya que no solo depende de las autoridades del Estado, sino de las mujeres que deben comprometerse y buscar las alternativas educacionales y financieras.
ANIMASI INTERAKTIF PEMBELAJARAN SHALAT MENGGUNAKAN METODE MULTIMEDIA DEVELOPMENT LIFE CYCLE PADA RA AT-TAUFIQ CIKARANG
Authors: Yulihani Yulihani , Masturoh Siti , Fazriansyah Agung , Kahfi Ahmad Hafidzul
Published: June 2022

Abstract— Education is one of the main foundations in shaping one's personality. Learning to pray must be instilled in children from an early age. Prayer is a weapon of believers, a pillar of religion, light in the sky and on earth. Prayers can prevent vile and morbid deeds. Prayers can be judged if they fulfill all the conditions and pillars. The obligation to perform prayer as well as by carrying out other obligations according to the Islamic Shari'ah. This research was conducted using the Adobe Flash application program, using the method of developing Multimedia Development Life Cycle (MDLC) software, the data collection method used in this study were Observation, Interview, and Library methods. From the results of this study, obtained an Interactive Animation of Five Times Prayer Learning using Adobe Flash CS6 as a learning vehicle for students and facilitating RA Ataufiq students at  Cikarang in obtaining material information, especially for prayer learning.
ANALISIS MANFAAT E- AGRICULTURAL MENGUNAKAN METODE SEMPLS (STUDY KASUS LIMAKILO.ID)
Authors: Arfian Andi
Published: June 2022

In the era of development of the world of digital information can be one of the answers to the challenges of the era in the current era. Answered, it answered the discussion in Indonesia, which was occasionally still haunted by the distribution chain that was too long and resulted in price spikes. One way is by implementing an online-based sales system and one of them is a partner with a profit sharing system between farmers and buyers. In its management, starting from capital lending, agricultural management, post-harvest processing to sales, packaging, to shipping. Each product supports the Limakilo.id website and the main objective is the empowerment of the Limakilo.id website for farmers in rural areas. In this study, researchers used the da Mclean delone model by using the sem method and qualitative pls tools. The purpose of this research is to study e-commerce. Most of the fields of agriculture can help improve the economics of farmers and villages in obtaining information on data but done through interviews, observations and direction of farmers and farmers of agricultural businesses in empowering the economy of rural communities in agriculture. The study analyzed activities regarding agricultural output in several villages in Sukamakmur District, Bogor Regency, West Java, using the system development model with the Delone and Mclean model and management data using SmartPls. From the results of this study it can be concluded that the limakilo e-commerce research. Id by Farmers also supports the agricultural economy in the villages is still very low in its utilization. Many are of the opinion and difficulties in carrying out these sales activities.
IMPLEMENTASI METODE WARD DAN PEPPARD DALAM PERENCANAAN SI/TI DI KANTOR ARSIP DAN PERPUSTAKAAN KOTA TASIKMALAYA
Authors: Pertiwi Melisa Winda
Published: June 2022

Development Strategy of Information Systems and Technology (SI/TI) in an organization of Government as well as a pemanfaata absolutely necessary to continue to improve the performance of employees in running business processes such as in the areas of coaching and Development Office of the archives and library of the town of Tasikmalaya don't have a business process excellence. Therefore, design kerangaka do it with in the planning SI/TI Using the method of analysis of the ward and Peppard has been in the form of results define strategy SI/TI The design of the framework of planning strategies SI/TI featuring the resulting Roadmap to future Application Portfolio. This future application can serve as a reference for the development of information systems are integrated to support the needs of the SI/TI Office of archives and library of the town of Tasikmalaya.
SISTEM PENGAMBILAN KEPUTUSAN KEPUASAN MUTU SEKOLAH DENGAN METODE PROFILE MATCHING
Authors: Dalis Sopiyan , Bahri Syamsul , Damanik Rahman Tuah
Published: June 2022

SMA Kanaan Global School  is a private school in Jakarta which has many achievements both in academic and non-academic terms including in the quality of the school. It cannot be separated from the use of even more information that is needed to always advance and develop in order to support the quality of school quality. For this reason, the writer tries to make a thesis on the assessment of school quality satisfaction at SMA Kanaan Global School Jakarta. This school itself is moving to improve quality towards national standard schools plus so that it is at the forefront of global competition. By more actively improving the quality of education and improving teacher qualifications, as well as increasing the average grade of passing national examinations to become one of the best and satisfying schools. In processing the data the author uses the profile matching method. the final results obtained by the author of the satisfaction of high school quality Kanaan Global School Jakarta Jakarta is "PUAS" with an assessment range of 3.6 - 4.5 as many as 37 respondents.
IMPLEMENTASI METODE NAIVE BAYES PADA ANALISA PENERIMAAN KARTU JAKARTA PINTAR DI SMK AL KAUTSAR JAKARTA
Authors: Fahdia Muhammad Rizki , Asnonik Novi , Putri Sukmawati Anggraeni Putri
Published: June 2022

Kemajuan dari suatu negara tergantung dari kemajuan dari aspek Pendidikan guna menciptakan pembangunan nasional yang lebih baik dan sebagai cara mencerdaskan anak bangsa. Pendidikan di Jakarta merupakan salah satu aspek yang menjadi cerminan untuk daerah-daerah lain yang ada di negara indoensia. Pemerintah DKI Jakarta melakukan pembangunan dalam aspek Pendidikan dengan program wajib belajar 12 tahun. Pada kenyataannya masih banyak anak yang putus sekolah karena keterbatasan kemampuan orang tua untuk memenuhi biaya Pendidikan. Pemerintah berupaya untuk memberikan subsidi antara lain Bantuan Operasional Sekolah (BOS), bantuan Operasional Pendidikan (BOP), dan Kartu Jakarta Pintar (KJP). Temuan pokok menunjukan bahwa pelanggaran dan penyalahgunaan dana Kartu Jakarta Pintar (KJP) masih terjadi. Masih banyak ketidakakuratan data dan masih salah sasaran meskipun pengelolaan aturan dan juga mekanisme sudah di berikan. Oleh karena itu, penulis menerapkan metode data mining untuk mengklasifikasikan diterimanya ajuan siswa dalam kategori diterima dan tidak diterima berdasarkan data KJP dimasa sebelumnya, kemudian digunakan dalam penentuan kelayakan ajuan siswa dimasa depan, yaitu dengan algoritma Naive Bayes. Penulis menggunakan aplikasi RapidMiner 9.2.0 untuk menguji tingkat akurasi algoritma tersebut. Pengujian dilakukan dengan menyiapkan data  sebanyak 324 data yang diambil dari Arsip KJP SMK Al-Kautsar Jakarta ditahun 2017-2019. Hasil pengujian akurasi yang didapatkan menggunakan aplikasi RapidMiner maupun perhitungan manual diperoleh akurasi yaitu 60.49% dengan persentase eror 39.50%. Jadi, dapat disimpulkan bahwa Algoritma Naive Bayes dapat diterapkan untuk penentuan kelayakan penerimaan Kartu Jakarta Pintar kepada siswa pada SMK Al-Kautsar Jakarta.
MODEL PENILAIAN SISWA TERHADAP PENERIMAAN MATERI AJAR KKPI BERDASARKAN PENDEKATAN FIS MAMDANI
Authors: Sartini Sartini
Published: June 2022

Tercapainya kepuasan siswa dalam proses pembelajaran, menunjukan pembelajaran dilaksanakan secara berkualitas. Penilaian siswa terhadap pemahaman materi ajar (khususnya matapelajaran KKPI), ditentukan berdasarkan silabus pengajaran KKPI antara lain pemahaman tentang system operasi, pengolahan software, pengolahan data, jaringan, dan web.  Evaluasi penilaian siswa terhadap penerimaan materi ajar KKPI masih menggunakan sistem manual hingga memakan waktu yang lama dan dapat berdampak pada hasil yang kurang akurat. Untuk itu perlu di buat model penilaian siswa terhadap penerimaan materi ajar KKPI berbasis komputer (soft computing)  menggunakan program Matlab 7.9.0.529 (R2009b) dengan menggunakan metode Fuzzy Inference System (FIS) Mamdani. Hasil yang dicapai adalah diperoleh aplikasi penilaian siswa terhadap penerimaan materi ajar KKPI dalam format Graphical User Interface (GUI) yang memudahkan proses penilaian dengan waktu yang lebih efisien.
Lapses: When Friends Clock Out
Authors: Ronell Avital
Published: June 2022

Remembrance involves so many shots in the dark, part of an effort to locate the disappeared as they clock out. In the dead center of Hölderlin’s hymn, Andenken, the question flares: ‘But–where are my friends?’ Nancy, writing on Derrida’s inconceivable demise, says we await them, demanding a return in some form, drawing on a shadowing nearness, maybe an image that appears in distinction to the non-image of the living friend. Have they really elapsed – ? Or, are they bound to show up at midnight, like the Rat Man’s father or Hamlet’s ghost? Derrida wonders if we don’t take another few laps with them, worried and anxious about their well-being over there. Ach! Give us the off chance of an apparition, a sign, an alias vanishing down the block. With Derrida Nancy turns a radical corner: We don’t have at hand the syntax to say a disappearance so resolute. We have no cause to assert a fact that is not fact, the factum negativum, of one perpetually disappearing. For nobody is dead, not so dead or dead so, as if we were not still involved in naming a state of being, of being de-parted. That is why he offers a sidebar on rethinking the philosophical formulation, ‘God is dead’.
Dynamics of indicators of chemical and biochemical oxygen consumption in the Southern Bug river for 2016–2020
Authors: Morozova L.
Published: June 2022

The analysis of modern ecological problems of the Southern Bug river basin is carried out, which allows to reveal the most painful ecological threats. Ways to solve these problems and optimize the management of environmental safety of water resources of Vinnytsia region are proposed. The article examines the dynamics of chemical and biochemical oxygen consumption in the Southern Bug basin and its main tributaries, starting in 2016 and ending in 2020. There is a tendency to increase the value of BOD5 annually in drinking water intakes of the Southern Bug basin in Kirovohrad region, which indicates an increase in water pollution of the rivers Ingul, Sukhoklia and Chorny Tashlyk organic compounds. It is shown that a significant part of organic pollution, estimated by BODp, is formed by the three largest cities: Vinnytsia, Khmelnytsky and Kropyvnytskyi. The total share of these cities among the studied point sources reaches 74% of the total amount of discharged organic matter identified by monitoring. Also, the pollution of the Southern Bug River with organic compounds is a consequence of their entry into surface waters from peatlands and swamps. The share of industry in surface water pollution, compared to utilities; industrial wastewater contains almost nine times less organic matter. The main sources of industrial pollution are Ladyzhyn TPP, Ingul and Smolin mines, JSC BOD in Voznesensk.
Scientific fundamentals of formation and development of agricultural land use on the basis of transformation of land relations
Authors: Drebot O. , Dobriak D. , Melnyk P. , Sakharnatska L.
Published: June 2022

The article highlights the essence of the concept of agricultural land use, its formation and development as a result of the transformation processes in land relations during land reform.
The concept of land use has been substantiated, which in the scientific interpretation is used in a double sense, namely: as a system of land use, regulated by law for different categories of land, landowners and land users; as a territory, land owned or used.
Considerable attention has been paid to the analysis and interpretation of the concepts of transformation, land use, reform and their derivatives, which led to the search for the optimal definition of the concept of transformation of agricultural land use.
It has been found that in market conditions, based on the implementation of transformation processes, there was a significant reduction in the area of arable land and an increase in ecologically stabilizing lands (hayfields, pastures) and wooded areas. This has a positive effect on solving environmental problems in the field of agriculture. However, practical experience confirms that such positive changes in land use will occur only if the structure of the land fund is improved. That is, degraded unproductive lands must be removed from active cultivation.
A proof of the Riemann hypothesis
Authors: Abe Yukitaka
Published: June 2022

We prove the Riemann hypothesis.
Hemoglobin and Red Blood Cells Count in Pregnant Sudanese Women
Authors: Awad Elmadih Manal Hamed , Khalid Abdurrahman , Abdelrhim Ali Ibrahim , Hussein Adam Abdurrahman , elaziz Musa Omer Abd
Published: June 2022

The study discussed the physiological changes of pregnancy in Sudanese pregnant women the study aimed to assess the effect of pregnancy in Red blood cell, Packed Cell Volume (PCV) and hemoglobin among Sudanese pregnant women, and to correlate the PCV as an indicator of hemodilution in different trimesters among Sudanese women using or not using iron and folic acid supplement. The researcher used across sectional study which applied on 300 pregnant women presented to Port-Sudan obstetrical Hospital for antenatal care from 2019 to 2020. The samples were collected with Chemically clean and sterile disposable needles, syringes and swab were used for all blood samples, 4.5 mL of blood was collected from each participant into a tube containing the anticoagulant Ethylene Diamine Tetraacetic Acid (EDTA), gently mixed the tube five to six times A full blood count was performed using Hematological analyzer (Sysmex XP 300). The study found out that 90 women in each trimester of pregnancy (first, second and third) the mean value of Hemoglobin (Hb) in pregnant women was 11.3±1.4 g/dl, 11.4 ±1.4 g/dl and 10.3±1.2 g/dl in 1st, 2nd and 3rd trimester respectively. The study also found out that the mean value of PCV was 33.35%. Moreover, Hb was lower during 3rd trimester compared with 1st (hemodilution). The cut off level for anemia in Sudanese non pregnant females could be even lower than 11g/dl as the normal level was found to be lower than the international one. Due to hemodilution anemia in pregnancy is considered if Hb less than 9g/dl. The study recommends that diagnosis of anemia should be revised during pregnancy as this study has shown Hb level less than 9g/dl (66%) can be the cut off level.
URBAN MINING BATERAI LITHIUM BEKAS SEBAGAI SUMBER ALTERNATIF BAHAN BAKU BATERAI LITHIUM
Authors: Puspita Daniel Fajar , Deni Cahyadi
Published: June 2022

Telah dibuat usulan urban mining yang menawarkan solusi tata kelola sampah baterai lithium. Hal ini dilatarbelakangi belum adanya sistem pengelolaan sampah yang spesifik menangani baterai lithium. Penelitian dilakukan secara kuantitatif untuk percobaan electrochemical discharge dan kualitatif untuk pengumpulan data, pengolahan dan perumusan usulan urban mining. Dari hasil penelitian eksperimental didapatkan bahwa NaCl 5% merupakan konsentrasi optimum untuk electrochemical discharge. Analisa kualitatif dari data tata kelola sampah di Indonesia didapat bahwa masih ditemukan kendala khususnya untuk sampah baterai lithium. Sistem urban mining yang diusulkan mencakup lingkup masyarakat dan pengumpul sementara. Diharapkan usulan urban mining ini bisa memberikan masukan untuk perencanaan tata kelola sampah baterai lithium yang efektif dan berwawasan lingkungan.
Pemanfaatan Fasilitas Kesehatan dan Biaya Pengeluaran bagi Akseptor KB dalam Mendapatkan Layanan Kontrasepsi di Jawa Barat
Authors: Nilam Sari Atriany , Susanti Ari Indra , Indraswari Noormarina
Published: June 2022

Introduction: The family planning program is a promotive and preventive service, including counseling and the use of non-long-term contraceptive methods and long-term contraceptive methods (MKJP). However, there is a decrease in the use of Intrauterine Contraceptive Devices caused by health service factors, namely procedures, health workers, costs, and infrastructure related to the selection of contraceptives. Purpose: This study describe the utilization of health facilities and the costs of spent by family planning acceptors in obtaining contraceptive services in West Java. Methods: This study used secondary data from the 2019 SKAP data with 5,430 modern family planning acceptors. Results: Most respondents, who used sterilization, IUDs, implants, and injections, received the services from private midwives (54.54%) and village midwives (24.25%). Meanwhile, for users of contraceptive pills and male condoms, the majority of respondents received these contraceptives from pharmacies/drug stores (64.9%). For non-MKJP users, 95.92% of them without insurance coverage. While 76,52% MKJP users also used the services without being covered by insurance. Conclusion: Utilization of health facilities with the cost of birth control services borne by BPJS or Jamkesda is still very low. Thus, promote health related to the use of MKJP and the use of BPJS need to be improved.
 
 
ABSTRAK
Pendahuluan: Program KB merupakan pelayanan promotif dan preventif, mencakup konseling dan penggunaan kontrasepsi non Metode Kontrasepsi Jangka Panjang (Non MKJP) dan Metode Kontrasepsi Jangka Panjang (MKJP). Terdapat penurunan pemakaian Alat Kontrasepsi Dalam Rahim (AKDR) disebabkan oleh prosedur, petugas, biaya, dan sarana prasarana yang berhubungan pemilihan alat kontrasepsi. Tujuan: Penelitian ini bertujuan untuk mengetahui pemanfaatan fasilitas kesehatan dan biaya pengeluaran bagi akseptor KB dalam mendapatkan layanan kontrasepsi di Jawa Barat. Metode: Penelitian ini menggunakan pendekatan potong lintang dengan data sekunder dari data Survei  Kuesioner Akuntabilitas Penelitian (SKAP) tahun 2019. Subjek penelitiannya adalah akseptor KB modern sebanyak 5.430 orang. Hasil: Pengguna alat/metode KB, (IUD, implan, dan suntik) paling banyak mendapatkan pelayanan KB dari praktik bidan swasta (54,54%) dan bidan desa (24,25%). Sedangkan untuk pengguna pil KB dan kondom pria paling banyak mendapatkan alat KB tersebut dari apotik/toko obat (64,9%). Pada bukan pengguna MKJP, sebanyak 95,92% tidak menggunakan asuransi dalam mendapatkan pelayanan KB. Sedangkan pengguna MKJP 76,52% responden juga tidak menggunakan asuransi. Simpulan: Pemanfaatan fasilitas kesehatan dengan biaya pelayanan KB yang ditanggung BPJS atau Jamkesda masih sangat rendah. Dengan demikian, upaya promosi kesehatan terkait penggunaan layanan MKJP dan pemanfaatan BPJS perlu ditingkatkan.
Theoretical Study of Alkaline-Earth Metal (Be, Mg, and Ca)-Substituted Aluminum Nitride Nanocages With High Stability and Large Nonlinear Optical Responses
Authors: He Hui-Min , Yang Hui , Li Ying , Li Zhi-Ru
Published: June 2022

By replacing one Al or N atom of aluminum nitride nanocage Al12N12 with an alkaline-earth metal atom, two series of compounds, namely, M@Al12N11 and M@Al11N12 (M = Be, Mg, and Ca), were constructed and investigated in theory. The substituted effect of alkaline-earth metal on the geometric structure and electronic properties of Al12N12 is studied in detail by density functional theory (DFT) methods. The calculated binding energies, HOMO–LUMO gaps, and VIE values of these compounds reveal that they possess high stability, though the NBO and HOMO analyses show that they are also excess electron compounds. Due to the existence of diffuse excess electrons, these alkaline-earth metal-substituted compounds exhibit larger first hyperpolarizabilities (β0) than pure Al12N12 nanocage. In particular, these considered compounds exhibit satisfactory infrared (IR) (>1800 nm) and ultraviolet (UV) (˂ 250 nm) transparency. Therefore, these proposed excess electron compounds with high stability may be regarded as potential candidates for new UV and IR NLO molecules.
Release Our River, Let the Salmon Swim: Skokomish Efforts to Restore Their River
Authors: Stoffle Richard
Published: June 2022

The Skokomish Indian people have successfully argued for the restoration of the North Fork of the Skokomish River on the Olympic Peninsula, USA. These people have adapted to and culturally incorporated this river since time immemorial, which is for well over 14,000 years. The tribe argued in a U.S. Federal court helped by three cultural anthropologists, for the release of river water from the two Cushman dams managed by Tacoma Water and Power (TWP). The tribe insisted that the cultural landscape produced by the traditional flow of the river still exist despite damage from the dams. They argued that returning river water could restore the salmon natural habitat and the people could have access to their spiritual locations. In 2009 a settlement between TWP and the Skokomish Indian Nation resulted in a 2010 amendment to the Federal Energy Regulatory Commission licensing agreement for the dams. This resulted in reassertion of tribal sovereignty, including restoration of channel maintaining flows and salmon populations. The case contributes to the discussion of the Protected Landscape Approach, Category V of the International Union for Conservation of Nature, World Commission on Protected Areas.
Model Embraced Electromechanical Coupling Time for Estimation of Heart Failure in Patients With Hypertrophic Cardiomyopathy
Authors: Hu Su , Mi Lan , Fu Jianli , Ma Wangxia , Ni Jingsong , Zhang Zhenxia , Li Botao , Guan Gongchang , Wang Junkui , Zhao Na
Published: June 2022

Objective

This study aimed to establish a model embraced electromechanical coupling time (EMC-T) and assess the value of the model for the prediction of heart failure (HF) in patients with hypertrophic cardiomyopathy (HCM).

Materials and Methods

Data on 82 patients with HCM at Shaanxi Provincial People’s Hospital between February 2019 and November 2021 were collected and then formed the training dataset (n = 82). Data were used to screen predictors of HF using univariate and multivariate analyses. Predictors were implemented to discover the optimal cut-off value, were incorporated into a model, and shown as a nomogram. The cumulative HF curve was calculated using the Kaplan–Meier method. Additionally, patients with HCM at other hospitals collected from March 2019 to March 2021 formed the validation dataset. The model’s performance was confirmed both in training and validation sets.

Results

During a median of 22.91 months, 19 (13.38%) patients experienced HF. Cox analysis showed that EMC-T courses in the lateral wall, myoglobin, PR interval, and left atrial volume index were independent predictors of HF in patients with HCM. Five factors were incorporated into the model and shown as a nomogram. Stratification of patients into two risk subgroups by applying risk score (<230.65, ≥230.65) allowed significant distinction between Kaplan–Meier curves for cumulative incidence of HF events. In training dataset, the model had an AUC of 0.948 (95% CI: 0.885–1.000, p < 0.001) and achieved a good C-index of 0.918 (95% CI: 0.867–0.969). In validation dataset, the model had an AUC of 0.991 (95% CI: 0.848–1.000, p < 0.001) and achieved a strong C-index of 0.941 (95% CI: 0.923–1.000). Calibration plots showed high agreement between predicted and observed outcomes in both two datasets.

Conclusion

We established and validated a novel model incorporating electromechanical coupling time courses for predicting HF in patients with HCM.
Role of Electromechanical Dyssynchrony Assessment During Acute Circulatory Failure and Its Relation to Ventriculo-Arterial Coupling
Authors: Andrei Stefan , Popescu Bogdan A. , Caruso Vincenza , Nguyen Maxime , Bouhemad Belaid , Guinot Pierre-Grégoire
Published: June 2022

Introduction

Two parallel paradigms of cardiovascular efficiency and haemodynamic optimisation coexist in haemodynamic research. Targeting ventriculo-arterial (VA) coupling [i.e., the ratio between arterial and ventricular elastance (EV)] and electromechanical coupling are two promising approaches in acute circulatory failure. However, validation of the parameters of electromechanical coupling in critically ill patients is ongoing. Furthermore, a unifying link between VA and electromechanical coupling may exist, as EV is correlated with different times of the cardiac cycle.

Materials and Methods

This study was a retrospective analysis of a prospectively collected observational database from one tertiary center ICU. We analyzed the relationship between electromechanical dyssynchrony and acute circulatory failure hemodynamics before and after treatment (i.e., fluid expansion, dobutamine, or norepinephrine infusion). The relationship between electromechanical coupling and VA coupling was also investigated. Adult patients with haemodynamic instability were included. Haemodynamic parameters, including arterial pressure, cardiac index, VA coupling, stroke work index/pressure–volume area (SWI/PVA), t-IVT, and Tei's index, were collected before and after treatment. A t-IVT of >12 s/min was classified as intraventricular dyssynchrony.

Results

We included 54 patients; 39 (72.2%) were classified as having intraventricular dyssynchrony at baseline. These patients with baseline dyssynchrony showed a statistically significant amelioration of t-IVT (from 18 ± 4 s to 14 ± 6 s, p = 0.001), left ventricular EV [from 1.1 (0.72–1.52) to 1.33 (0.84–1.67) mmHg mL−1, p = 0.001], VA coupling [from 2 (1.67–2.59) to 1.80 (1.40–2.21), p = 0.001], and SWI/PVA [from 0.58 (0.49–0.65) to 0.64 (0.51–0.68), p = 0.007]. Patients without baseline dyssynchrony showed no statistically significant results. The improvement in VA coupling was mediated by an amelioration of EV. All patients improved their arterial pressure and cardiac index with treatment. The haemodynamic treatment group exhibited no effect on changing t-IVT.

Conclusion

Acute circulatory failure is associated with electromechanical dyssynchrony. Cardiac electromechanical coupling was improved by haemodynamic treatment only if altered at baseline. The improvement of cardiac electromechanical coupling was associated with the improvement of markers of cardiocirculatory efficacy and efficiency (i.e., SWI/PVA and VA coupling). This study was the first to demonstrate a possible link between cardiac electromechanical coupling and VA coupling in patients with acute circulatory failure.
Causal Inference in the Presence of Interference in Sponsored Search Advertising
Authors: Nabi Razieh , Pfeiffer Joel , Charles Denis , Kıcıman Emre
Published: June 2022

In classical causal inference, inferring cause-effect relations from data relies on the assumption that units are independent and identically distributed. This assumption is violated in settings where units are related through a network of dependencies. An example of such a setting is ad placement in sponsored search advertising, where the likelihood of a user clicking on a particular ad is potentially influenced by where it is placed and where other ads are placed on the search result page. In such scenarios, confounding arises due to not only the individual ad-level covariates but also the placements and covariates of other ads in the system. In this paper, we leverage the language of causal inference in the presence of interference to model interactions among the ads. Quantification of such interactions allows us to better understand the click behavior of users, which in turn impacts the revenue of the host search engine and enhances user satisfaction. We illustrate the utility of our formalization through experiments carried out on the ad placement system of the Bing search engine.
Effect of Orthodontic Appliances on the Oral Environment and Microbiome
Authors: Mulimani Priti , Popowics Tracy
Published: June 2022

Orthodontic treatment is an appliance-intensive endeavor, where an array of mechanical devices is used to bring about tooth movement. By virtue of remaining in close proximity to the enamel, gingiva and periodontal ligament intra-orally over a prolonged period of time, orthodontic appliances have a significant impact on the paradental tissues, oral environment and oral microbiome. Orthodontic appliances, by acting as anchors for biofilm and plaque formation, accumulate bacteria and other microorganisms in amounts unfavorable for maintenance of healthy equilibrium. The resulting loss of balance in the oral microbiome causes dysbiosis, which manifests clinically as increased enamel demineralization, dental caries and periodontal disease. Mechanical removal of the accumulated plaque by maintaining rigorous oral hygiene has been proven to be the single most important factor to mitigate the harmful effects of dysbiosis. This review investigates how each of the various components of orthodontic appliances, different types of appliances and unique surface properties of biomaterials have contributory effects at the interface of orthodontic biomaterials and oral biology. The information thus obtained will be critical in instituting the best diagnostic and therapeutic measures at the clinical level. It will also be instrumental in devising improvements and providing new directions for future research in general and precision orthodontics in particular.
Eco-Friendly Energy Production: The Influence of Price Factors in the Regions of Russia
Authors: Roslyakova Natalia , Vechkinzova Elena
Published: June 2022

Our review focuses on statistical data on the relationship between electricity prices and emissions, energy availability, and energy consumption in 2017–2020. We used the nonparametric method of data envelopment analysis (DEA) as a methodological basis for analyzing the impact of the "green policy" on electricity consumption in the regions of Russia and regression analysis to quantify dependencies between the parameter. The results of the DEA allowed us to check the effectiveness of the ratio of costs (emissions) and results (electricity consumption by the population and industry). The results of the regression analysis allowed us to find the equation of the relationship between the amount of electricity generated by a renewable energy source (RES), the amount of consumption, and average electricity prices. The obtained equations proved the strong influence of an increase in the amount of energy generated from renewable energy sources on the average electricity price increase and a decrease in energy consumption. In the conclusion, we talk about the low elasticity of the demand for electricity from the Russian population and the significant impact of electricity generated by the RES on increasing the average prices of energy producers and reducing energy consumption.
Coexistence, Energy, and Trophic Cascade in a Three-Level Food Chain Integrating Body Sizes
Authors: Campillay-Llanos William , Córdova-Lepe Fernando D. , Moreno-Gómez Felipe N.
Published: June 2022

Predation is a biological interaction that influences demographic patterns by modifying community structure. In the current ecological crisis, there is a need to better understand the conditions of coexistence between predators, prey and their resources. The body size is considered a key feature to explain community-scale phenomena, energetic, and evolutionary constraints. This raises the question of how species body size directly or indirectly affects the demographic patterns that enable coexistence. Considering the above, we conducted a theoretical study that implements a Rosenzweig-MacArthur type model, which represents a three-level chain that integrates body sizes and includes a Holling type I functional response. In this model, we characterize coexistence through body size-dependent net reproductive rates. Our results suggest that the body sizes of consumer species strongly affect the size-density relations and energy requirements. We obtain the negative relationship between body size and density of intermediate consumers and discuss the energy equivalence rule. Furthermore, larger predators have a more significant impact on the intensity of the trophic cascade than smaller predators. Finally, we discuss potential extensions and applications of our modeling approach.
Honey-Bearing Potential of Tilia cordata Mill. Forests in the Southern Urals
Authors: Sultanova Rida , Martynova Maria , Sazgutdinova Regina
Published: June 2022

This article examined the honey-bearing potential of Tilia cordata Mill. stands in the Southern Urals using forest management and taxation methods. The studies were conducted in pure and mixed even- and uneven-aged forests with T. cordata Mill. in different natural zones of the Southern Urals on the territory of the Bashkirs. These were forests of the South Ural forest-steppe region, the forest-steppe region of the European part of Russia, the area of coniferous-deciduous (mixed) forests of the European part of Russia. The research employed the method of laying temporary and permanent trial areas. T. cordata Mill. forests on the republic’s territory were divided into zones by forest districts. There is a discrepancy between the territorial localization of “nectar” (honey-bearing) linden and designated forest areas, that is, honey-bearing forest areas on the republic’s territory. It could be due to the lacking methodology for assigning linden to these categories. The increased rotation age of linden trees to 81–90 years for several decades, a ban on final cutting, reduced annual cut of soft-leaved forests by 15% enlarged the stocks of overmature forest to 48%. Depending on the age, the number of flowers on one T. cordata Mill. tree varies from 0 to 60.2 thousand pieces. The maximum amount of nectar is 69.04 kg/ha at 12-day linden flowering. The honey productivity of plants including T. cordata Mill., calculated concerning the linden age, its share in the forest composition, the average number of flowers on the tree, nectar per 1 ha of linden and the flowering period ranged from 252.8 to 662.8 kg/ha.
Genetic Diversity Analysis of the Chinese Daur Ethnic Group in Heilongjiang Province by Complete Mitochondrial Genome Sequencing
Authors: Jia Mansha , Li Qiuyan , Zhang Tingting , Dong Bonan , Liang Xiao , Fu Songbin , Yu Jingcui
Published: June 2022

Mitochondrial DNA (mtDNA) has the characteristics of maternal inheritance, high mutation rate, high copy number, and no recombination. As the most powerful tool for studying the origin and evolution of modern humans, mtDNA has great significance in the research of population genetics and evolutionary genetics. Here, we provide new insights into the maternal genetic history of the Daur ethnic group by generating complete mitochondrial genomes from a total of 146 Daur individuals in China. We also collected the published complete mitochondrial genome sequences of 5,094 individuals from 56 worldwide populations as reference data to further explore the matrilineal genetic landscape of the Daur ethnic group. First, the haplotype diversity was 0.9943 ± 0.0019 and nucleotide diversity was 0.0428 ± 0.0210. The neutrality tests of the Daur group showed significant negative values and the mismatch distribution curve was obviously distributed in a unimodal pattern. The results showed that the Daur ethnic group has high genetic diversity and may have experienced recent population expansion. In addition, the main haplogroups of the Daur population were haplogroup D (31.51%), M* (20.55%), C (10.28%), F (7.53%), and B (6.85%), all of which were prevalent in northern China. It probably implies the northern Chinese origin of the Daur population. The PCA, FST, and phylogenetic analysis results indicated that the Daur group formed a cluster with East Asian populations, and had few genetic differences with the populations in northern China. More importantly, we found that disease-related mutation sites of the mitochondrial genome may be related to ethnic groups, which may have important implications for the prevention and occurrence of specific diseases. Overall, this study revealed the complexity and diversity of the matrilineal genetic background of the Daur ethnic group. Meanwhile, it provided meaningful data for the research on the diversity of the human genome.
Potential Determinants for Radiation-Induced Lymphopenia in Patients With Breast Cancer Using Interpretable Machine Learning Approach
Authors: Yu Hao , Chen Fang , Lam Ka-On , Yang Li , Wang Yang , Jin Jian-Yue , EI Helali Aya , Kong Feng-Ming (Spring)
Published: June 2022

Radiation-induced lymphopenia is known for its survival significance in patients with breast cancer treated with radiation therapy. This study aimed to evaluate the impact of radiotherapy on lymphocytes by applying machine learning strategies. We used Extreme Gradient Boosting (XGboost) to predict the event of lymphopenia (grade≥1) and conduced an independent validation. Then, we induced feature attribution analysis (Shapley additive explanation, SHAP) in explaining the XGboost models to explore the directional contribution of each feature to lymphopenia. Finally, we implemented the proof-of-concept clinical validation. The results showed that the XGboost models had rigorous generalization performances (accuracies 0.764 and ROC-AUC 0.841, respectively) in the independent cohort. The baseline lymphocyte counts are the most protective feature (SHAP = 5.226, direction of SHAP = -0.964). Baseline platelets and monocytes also played important protective roles. The usage of taxane only chemotherapy was less risk on lymphopenia than the combination of anthracycline and taxane. By the contribution analysis of dose, we identified that firstly lymphocytes were sensitive to a radiation dose less than 4Gy; secondly the irradiation volume was more important in promoting lymphopenia than the irradiation dose; thirdly the irradiation dose promoted the event of lymphopenia when the irradiation volume was fixed. Overall, our findings paved the way to clarifying the radiation dose volume effect. To avoid radiation-induced lymphopenia, irradiation volume should be kept to a minimum during the planning process, as long as the target coverage is not compromised.
Effects of Occult Hypoperfusion on Local Circulation and Inflammation - An Analysis in a Standardized Polytrauma Model
Authors: Halvachizadeh Sascha , Kalbas Yannik , Teuben Michel Paul Johan , Teuber Henrik , Cesarovic Nikola , Weisskopf Miriam , Cinelli Paolo , Pape Hans-Christoph , Pfeifer Roman
Published: June 2022

Introduction

Occult hypoperfusion (OH) is defined as persistent lactic acidosis despite normalization of vital parameters following trauma. The aim of this study was to analyze the association of occult hypoperfusion with local circulation and inflammation of injured soft tissue in a porcine polytrauma model.

Methods

This experimental study was performed with male landrace pigs who suffered a standardized polytrauma, including a femoral fracture, blunt chest trauma, liver laceration and a mean arterial pressure (MAP) controlled hemorrhagic shock. One hour after induction of trauma, the animals were resuscitated with retrograde femoral nailing, liver packing and volume replacement. Animals were stratified into Group Norm (normalizing lactate levels after resuscitation) and Group occult hypoperfusion (OH) (persistent lactate levels above 2 mmol/l with normalizing vital parameters after resuscitation). Local circulation (oxygen saturation, hemoglobin amount, blood flow) was measured with optical sensors at the subcutaneous soft tissue at the fractured extremity as well as at the stomach and colon. Local inflammatory parameters [interleukin (IL) 6, 8, 10, and heat shock protein (HSP)] were analyzed in the subcutaneous tissue of the fractured extremity.

Results

Group Norm (n = 19) and Group OH (n = 5) were comparable in baseline vital and laboratory parameters. The shock severity and total amount of blood loss were comparable among Group Norm and Group OH. Following resuscitation Group OH had significantly lower local relative hemoglobin amount at the injured soft tissue of the fractured extremity when compared with Group Norm (39.4, SD 5.3 vs. 63.9, SD 27.6 A.U., p = 0.031). The local oxygenation was significantly lower in Group OH compared to Group Norm (60.4, SD 4.6 vs. 75.8, SD 12.8, p = 0.049). Local IL-6 in the fatty tissue was significantly higher in Group OH (318.3, SD 326.6 [pg/ml]) when compared with Group Norm (73.9,SD 96.3[pg/ml], p = 0.03). The local circulation at the abdominal organs was comparable in both groups.

Conclusion

OH is associated with decreased local circulation and increased local inflammation at the injured soft tissue of the extremity in polytrauma. OH might reflect the severity of local soft tissue injuries, and guide treatment strategies.
Timing of Tocilizumab Administration Under the Guidance of IL-6 in CAR-T Therapy for R/R Acute Lymphoblastic Leukemia
Authors: Zhang Yinqiang , Zhou Fen , Wu Zhuolin , Li Yingnan , Li Chenggong , Du Mengyi , Luo Wenjing , Kou Haiming , Lu Cong , Mei Heng
Published: June 2022

Chimeric antigen receptor T (CAR-T) cells targeting CD19 have achieved great clinical responses in patients with relapsed or refractory (R/R) acute B lymphoblastic leukemia. However, severe adverse events such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome restrict it to further application. Tocilizumab is the corner stone for the treatment of severe CRS. It has been used to treat mild CRS in recent years, whereas some statistical supports clarifying the suitable timing of its administration are lacking. Sixty-seven patients with B-cell acute lymphoblastic leukemia (B-ALL) were treated with CD19-CART and enrolled in the study, of which 33 patients received Tocilizumab. Application of Tocilizumab in patients with grade 2 CRS in American Society for Transplantation and Cellular Therapy (ASTCT) criteria can significantly shorten the duration of CRS without affecting side effects and long-term efficacy. However, a number of patients still developed severe CRS with early use of Tocilizumab, indicating the significance of the introduction of clinical laboratories to assist medications. Statistically, patients with less than fourfold increase in IL-6 levels had a higher incidence of severe CRS after receiving Tocilizumab (37.5% versus. 0%, p=0.0125), which provided a basis for refining CRS intervention strategies under the guidance of IL-6.

Clinical Trial Registration

www.clinicaltrials.gov, NCT02965092 and NCT04008251
Distribution and Production of N2O in the Subtropical Western North Pacific Ocean During the Spring of 2020
Authors: Heo Jang-Mu , Kim Hyo-Ryeon , Eom Sang-Min , Yoon Joo-Eun , Shim JeongHee , Lim Jae-Hyun , Kim Ju-Hyoung , Thangaraj Satheeswaran , Park Ki-Tae , Joo HuiTae , Kim Il-Nam
Published: June 2022

Nitrous oxide (N2O) is an important greenhouse gas emitted in significant volumes by the Pacific Ocean. However, the relationship between N2O dynamics and environmental drivers in the subtropical western North Pacific Ocean (STWNPO) remains poorly understood. We investigated the distribution of N2O and its production as well as the related mechanisms at the surface (0–200 m), intermediate (200–1500 m), and deep (1500–5774 m) layers of the STWNPO, which were divided according to the distribution of water masses. We applied the transit time distribution (TTD) method to determine the ventilation times, and to estimate the N2O equilibrium concentration of water parcels last in contact with the atmosphere prior to being ventilated. In the surface layer, biologically derived N2O (ΔN2O) was positively correlated with the apparent oxygen utilization (AOU) (R2 = 0.48), suggesting that surface N2O may be produced by nitrification. In the intermediate layer, ΔN2O was positively correlated with AOU and NO3− (R2 = 0.92 and R2 = 0.91, respectively) and negatively correlated with nitrogen sinks (N*) (R2 = 0.60). Hence, the highest ΔN2O value in the oxygen minimum layer suggested N2O production through nitrification and potential denitrification (up to 51% and 25% of measured N2O, respectively). In contrast, the deep layer exhibited a positive correlation between ΔN2O and AOU (R2 = 0.92), suggesting that the N2O accumulation in this layer may be caused by nitrification. Our results demonstrate that the STWNPO serves as an apparent source of atmospheric N2O (mean air−sea flux 2.0 ± 0.3 μmol m-2 d-1), and that nitrification and potential denitrification may be the primary mechanisms of N2O production in the STWNPO. We predict that ongoing ocean warming, deoxygenation, acidification, and anthropogenic nitrogen deposition in the STWNPO may elevate N2O emissions in the future. Therefore, the results obtained here are important for elucidating the relationships between N2O dynamics and environmental changes in the STWNPO and the global ocean.