bluuebunny/crossref_metadata_2025 huggingface dataset:
An Improved Demand Forecasting Model Using Deep Learning Approach and Proposed Decision Integration Strategy for Supply Chain
Authors: Kilimci Zeynep Hilal , Akyuz A. Okay , Uysal Mitat , Akyokus Selim , Uysal M. Ozan , Atak Bulbul Berna , Ekmis Mehmet Ali
Published: March 2019

Demand forecasting is one of the main issues of supply chains. It aimed to optimize stocks, reduce costs, and increase sales, profit, and customer loyalty. For this purpose, historical data can be analyzed to improve demand forecasting by using various methods like machine learning techniques, time series analysis, and deep learning models. In this work, an intelligent demand forecasting system is developed. This improved model is based on the analysis and interpretation of the historical data by using different forecasting methods which include time series analysis techniques, support vector regression algorithm, and deep learning models. To the best of our knowledge, this is the first study to blend the deep learning methodology, support vector regression algorithm, and different time series analysis models by a novel decision integration strategy for demand forecasting approach. The other novelty of this work is the adaptation of boosting ensemble strategy to demand forecasting system by implementing a novel decision integration model. The developed system is applied and tested on real life data obtained from SOK Market in Turkey which operates as a fast‐growing company with 6700 stores, 1500 products, and 23 distribution centers. A wide range of comparative and extensive experiments demonstrate that the proposed demand forecasting system exhibits noteworthy results compared to the state‐of‐art studies. Unlike the state‐of‐art studies, inclusion of support vector regression, deep learning model, and a novel integration strategy to the proposed forecasting system ensures significant accuracy improvement.
A Review on Managing Agroecosystems for Improved Water Use Efficiency in the Face of Changing Climate in Tanzania
Authors: Kimaro Jerome
Published: March 2019

Agroecosystems are important for food production and conservation of biodiversity while continuing to provide several ecosystem services within the landscape. Despite their economic and ecological benefits, most agroecosystems in Tanzania are degraded at alarming rates. Rapid increase of human population and unprecedented impacts of climate change have influenced depletion of natural resource base within agroecosystem in recent decades compared to what communities have experienced before. Increased food demands owing to population increase have increased pressure on exploitation of land resources including water. Cultivation area and irrigation water demands have increased steadily in the last six decades. Nevertheless, approaches used for water supply have not been improved; thus, water use efficiency in most irrigation schemes is quite poor. Conversely, climate smart agricultural practices are practiced less in Tanzania. There is poor adoption of recommended adaptation among smallholder farmers due to several socioeconomic reasons. One of the key objectives of climate smart agriculture is to improve bio-geochemical interactions within landscape and decrease competition of natural resources between humans and other component of agroecosystems. This underscores the assumptions that most cropping systems in Tanzania are not managed sustainably. Moreover, comprehensive assessment of hydrological dynamics within smallholder farming in Tanzania is highly lacking. Therefore, actual causes and extent of water resources depletion are largely unknown among stakeholders. In most tropical landscapes, water resources degradation is influenced by interaction of both anthropogenic and biophysical factors operating at different times and space scales. As the capacity of water-supplying sources continues to decline, Tanzania needs profound changes in agricultural production systems in order to nourish the growing human population. This calls for strategic approaches that have wider adaptability. A literature survey study with the following objectives was conducted (i) to assess current state of agricultural water use and irrigation activities in Tanzania and (ii) to determine major constraints for sustainable water management and identify appropriate adaptation measures for their improvement across diverse cropping systems.
EWSR1-NFATC2 and FUS-NFATC2 Gene Fusion-Associated Mesenchymal Tumors: Clinicopathologic Correlation and Literature Review
Authors: Bode-Lesniewska Beata , Fritz Christine , Exner Gerhard Ulrich , Wagner Ulrich , Fuchs Bruno
Published: March 2019

The spectrum of mesenchymal tumors associated with rearrangements of the EWSR1 gene has been growing in recent years due to progress in molecular detection techniques. Originally identified as the gene involved in the pathogenesis of Ewing sarcoma, the EWSR1 gene is now known to be rearranged in diverse clinical and histopathological entities. The NFATC2 gene is one of the many translocation partners of EWSR1 in gene fusions in a morphologically typical, albeit rare, subgroup of mesenchymal tumors. Little is known about the clinical characteristics of tumors containing NFATC2 gene rearrangements since most of the few reports published describe molecular rather than clinical aspects. In the current study, we report three patients with tumors carrying the EWSR1-NFATC2 gene translocation, including one rare primary tumor of soft tissues. Another patient with a benign-appearing bone tumor with a unique FUS-NFATC2 gene translocation is described. In various mesenchymal tumors (e.g., myxoid/round cell liposarcoma, low-grade fibromyxoid sarcoma, or angiomatoid fibrous histiocytoma), the FUS gene, as a member of the TET family, may be alternatively rearranged instead of the EWSR1 gene without any noticeable influence on the microscopical appearance or clinical outcome. This fact seems not to apply to mesenchymal tumors with the involvement of the NFATC2 gene because both in our experience and according to the extensive literature review, they have different properties on the morphological and molecular level. Both ESWSR1-NFATC2 and FUS-NFATC2 fusion-carrying tumors do not show microscopical or clinical features of Ewing sarcoma.
Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol
Authors: Wang Dongying , Zhao Chunhua , Fu Li , Liu Yang , Zhang Weiyang , Xu Tianmin
Published: March 2019

Objectives. Cervical clear cell adenocarcinoma (CCAC) is a rare malignant tumor with independent biological behavior in the female reproductive system. In this report, we collect the clinical and histopathological characteristics of 18 CCAC patients without exposure to diethylstilbestrol (DES) and conduct relevant clinical analysis. Methods. We retrospectively analyzed the clinical data of 18 patients with CCAC who were diagnosed and treated from January 2009 to August 2017 in the Second Hospital of Jilin University. Results. A total of 18 patients were enrolled. The age of patients ranged from 37 to 74 years with the peak incidence between 45 and 55 years. The median age was 53 years. The most common symptom was vaginal bleeding (66.7%, 12/18). The most common type of lesion was the endocervical type (66.7%, 12/18). The negative rate of human papillomavirus (HPV) examination was 88.9% (8/9). Based on the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) cervical cancer clinical stage in 2018, 55.6% patients were stage I (n=10), 16.7% were stage II (n=3), 22.2% were stage III (n=4), and 5.6% were stage IV (n=1). Seventeen patients underwent surgery; 64.7% (11/17) of cases showed infiltration of the entire layer of the cervix, pelvic lymph node (PLN) metastasis was observed in 4 patients (26.7%, 4/15), endometrium metastasis was observed in 4 patients (25%, 4/16), and 13 patients (72.2%, 13/18) were diagnosed at an early stage (stage IB1-IIA2). Fifteen patients’ immunohistochemistry indicated that napsin A, CK7, CK (AE1/AE3), and PAX-8 were positive, and p53, p16, ER, and vimentin were expressed to different degrees. Follow-up data were obtained in 13 patients (72.2%, 13/18). One patient died of recurrence 5 months after surgery, and the other patients’ progression-free survival (PFS) ranged from 9 to 59 months. Tumor size (>4 cm), tumor stage (FIGO IIA2-IV), PLN, and endometrium metastasis had negative effects on PFS (P<0.05). Conclusions. CCAC is a highly invasive malignant tumor, whose pathogenesis may not be associated with HPV infection. Radical hysterectomy combined with chemotherapy (paclitaxel + platinum) has the ideal short-term curative effect. In the future, larger samples of clinical data are required to confirm these insights.
Association Between Extra-Genital Congenital Anomalies and Hypospadias Outcome
Authors: Al-Juraibah Fahad , Lucas-Herald Angela , Nixon Rachael , Toka Christine , Wang Cunyi , Flett Martyn , O'Toole Stuart , Ahmed S Faisal
Published: March 2019

Extra-genital congenital anomalies are often present in cases of hypospadias, but it is unclear whether they have an association with the outcome of hypospadias surgery. The aim of this study was to review all hypospadias cases that had surgery between 2009 and 2015 at a single centre and identify clinical determinants of the surgical outcome. An extra-genital congenital anomaly was reported in 139 (22%) boys and 62 (10%) had more than 1 anomaly. Of the 626 boys, 54 (9%), including 44 with proximal hypospadias, had endocrine as well as limited genetic evaluation. Of these, 10 (19%) had a biochemical evidence of hypogonadism and 5 (9%) had a molecular genetic abnormality. At least 1 complication was reported in 167 (27%) patients, with 20% of complications (most frequently fistula) occurring after 2 years of surgery. The severity of hypospadias and the existence of other anomalies were clinical factors that were independently associated with an increased risk of complications (p < 0.001). In conclusion, complications following surgery are more likely in those cases that are proximal or who have additional extra-genital anomalies. To understand the biological basis of these complications, there is a greater need to understand the aetiology of such cases.
Sebaceous gland adenoma in a free-ranging Baird’s Tapir Tapirus bairdii (Tapiridae: Perissodactyla)
Authors: Arguedas Randall , Guevara-Soto Marcruz , Rojas-Jiménez Jorge
Published: March 2019

An external mass was observed on the ear of a free-ranging Baird’s Tapir Tapirus bairdii.  The mass was surgically removed under general anesthesia and was histopathologically identified as sebaceous gland adenoma. Hematological and biochemical analyses were also performed.  The animal showed a mild anemia and the other values were unremarkable.  Only few cases of tumors have been reported in tapirs and this is the first report of a tumor in a free ranging Baird´s Tapir.  The presence of any disease in free-ranging wildlife should call our attention in order to develop a better understanding of disease ecology, especially in threatened species.
Overcoming the Impassable Gulf: Phenomenologizing Psychophysics
Authors: Whitehead Patrick M. , Smith Tayha G.
Published: March 2019

This paper examines Fechner’s (1859) introduction to experimental psychophysics from a phenomenological perspective. Horst’s (2005) analysis is used to demonstrate the phenomenology that is inherent to classical perceptual psychophysics (Fechner’s “outer” psychophysics). Horst argues that the psychophysical event of perception can only be understood as an intentional intertwining of subject and object. From this we move to physiological component of psychophysics—that is, the processes that mediate perceptual awareness (Fechner’s “inner” psychophysics). Drawing primarily on the work of Rosen (2008, 2015), it is argued the phenomenology provides the most appropriate approach for what could be understood as a contemporary psychophysics—one that borrows from recent trends in physics, neuro-physiology, and perception as classical psychophysics had done (or promised to do). This results in a psychiatric neurophenomenology. Examples of the placebo effect and treatment of traumatic brain injury are used to demonstrate the usefulness of a phenomenological psychophysics, one that ultimately meets the demands of Fechner’s original proposal.
Checklist of the adult nematode parasites of fishes in freshwater localities from Mexico
Authors: GARRIDO-OLVERA LORENA , GARCÍA-PRIETO LUIS , DE LEÓN GERARDO PÉREZ-PONCE
Published: March 2019

Based on original data gathered from fieldwork during the last years and from previous records from all published accounts, a checklist of the adult nematode parasites of freshwater fishes from Mexico is presented. The checklist is organized as a nematode-host list and comprises taxonomic and geographic distributional information. In total, the checklist includes 70 taxa (50 identified at species level) pertaining to 13 families. These taxa have been collected from 107 freshwater fish taxa in 198 localities along the Mexican Republic. The information we provide herein indicates that sampling effort has been concentrated in Central and South East Mexico, with the Northern region remaining mostly unexplored. The proportion of endemic nematodes is high in the country (74%, i.e., 37 of the 50 taxa identified at species level). The family Rhabdochonidae displays the highest species richness (12 species), and Rhabdochona kidderi is the most widespread nematode species in the country. Cichlids represent the host group with the largest number of samples in Mexico. Finally, we present a list containing new records of larval nematodes from localities in the states of Michoacán, Nayarit, Oaxaca, Tamaulipas and Veracruz.
Revision of Neotropical species of Empidoidea (Diptera) described by Mario Bezzi. X. The species described in Apalocnemis Philippi (Brachystomatidae, Trichopezinae)
Authors: RAFAEL J. A. , SINCLAIR BRADLEY J.
Published: March 2019

Bezzi described two species in Apalocnemis Philippi, which at that time was placed in Empididae. This genus is presentlyassigned to Brachystomatidae, Trichopezinae. The type specimen of A. variegata Bezzi, 1905 is lost. Apalocnemis cingulata Bezzi, 1909 is redescribed and a lectotype designated based on a male specimen from Sicuani, Peru.
Caridina vithuraensis sp. nov. (Decapoda: Atyidae) from Vamanapuram River, Kerala region of Western Ghats, India
Authors: VIJAYAMMA JAYACHANDRAN KUNJURAMAN , THOMAS TESSA
Published: March 2019

A new species of Caridina H. M. Edwards, 1837, namely, C. vithuraensis, collected from Kallar, a tributary of Va-manapuram River, Kerala at Vithura is being described in this paper. The species is characterized by : small shrimps hav-ing short rostrum, extending to the tip of 1st segment of antennular peduncle, rarely reaching beyond, rostral formula : 11–19/2–5 (2–5 post-orbital); carpus of 1st pereiopod deeply excavated, 1.3 to 1.45 times as long as broad; dactylus of 3rdpereiopod ends in a terminal spine and with 5–7 accessory spines; dactylus of 5th pereiopod with 24–45 comb-likespinules; appendix interna on endopod of male 1st pleopod is prominent; uropodal diaeresis with 16–20 spines; telson con-ical in shape with 4–6 pairs of spinules on the dorsal and 6–8 spinules at the distal end. The species shows affinities withspecies like C. malayensis Cai et al., 2007; C. congoensis Richard & Clark, 2009 and C. roubaudi Richard & Clark, 2009. However they can be separated based on the specific characters given in Table 1.
A new iridescent “elfin” butterfly species of Podanotum (Lepidoptera: Lycaenidae: Eumaeini) from the Colombian Andes
Authors: PRIETO CARLOS , RODRIGUEZ GABRIEL
Published: March 2019

A new butterfly species, Podanotum pulsar Prieto & Rodríguez n. sp. is described from the high Andes of Colombia. Wepresent a brief discussion on its systematic placement and on adult ecology. Adult specimens and the genitalia of the male andfemale are illustrated and compared with the most closely related species Podanotum glorissimum Bálint & Wojtusiak, according to morphological characters.
Contribution to the knowledge of the Nolini of the Maputo Special Reserve in South Mozambique with description of two new species and several taxonomic updates (Lepidoptera, Nolidae, Nolinae)
Authors: LÁSZLÓ GYULA M. , VETINA ALVARO A.
Published: March 2019

Present paper contains the first comprehensive summary of the Nolini species of the Maputo Special Reserve collected between November 2016 and February 2018. The Nolini fauna counts 21 species in total, 17 species are proved to be new for the fauna of Mozambique, two species are new to science and described here as Mecothrix maputuana sp. n. and Meganola shangaana sp. n. The subgenus Mecothrix Hacker, 2012 is upgraded to genus rank. Mecothrix cana Hacker, 2012 and Nola submelanoscelis Hacker, 2012 are downgraded to subspecies rank (Mecothrix aegyptiaca cana Hacker, 2012 stat. n., Nola biangulata submelanoscelis Hacker, 2012 stat. n.). Meganola meridianissima Hacker, 2012 syn. n. and Meganola kakamega Hacker, 2012 syn. n. are synonymized with Meganola bispermutata Hacker, 2012, in addition Nolidia nanoxantha Hacker, 2012 syn. n. and Nolidia polionana Hacker, 2012 syn. n. are synonymised with Nolidia elachistomorpha Hacker, 2012. Nolidia elachistomorpha is transferred to the genus Hampsonola László, Ronkay & Ronkay, 2015 (Hampsonola elachistomorpha (Hacker, 2012) comb. n.). With 43 colour and 40 black and white figures.
On the Effectiveness of airborne infrasound in eliciting vestibular-evoked myogenic responses
Authors: Jurado Carlos , Marquardt Torsten
Published: March 2019

The use of airborne infrasound and other stimuli to elicit (cervical) vestibular-evoked myogenic potentials (cVEMPs) was studied to address the common proposition that infrasound may efficiently stimulate the vestibular system, an effect which may underlie the so-called wind-turbine syndrome. cVEMPs were measured for both ears of 15 normal-hearing subjects using three types of airborne sound stimulation: (1) 500-Hz tone bursts (transient); (2) 500-Hz sinusoidally amplitude-modulated tones at a 40-Hz rate (SAM); and (3) low-frequency and infrasound pure tones (LF/IS). The two former stimulation types served as control and allowed a systematic comparison with (3). It was found that SAM stimulation is effective and appears to be comparable to transient stimulation, as was previously observed in a yet small number of studies. Although the vestibular system is reported to be highly sensitive to low-frequency mechanical vibration, airborne LF/IS stimulation at ∼80–90-phon loudness levels did not elicit significant saccular vestibular responses.
Underwater laser communication with sloped pulse modulation in turbid water
Authors: Kang Taewoong , Kim Kiman , Kim Serim , Lee Donghun
Published: March 2019

In this article, we propose the demonstration of an underwater wireless laser communication link operating at data rates of up to 100 Mbps over a band-limited turbid water channel using a modified pulse position modulation scheme with a sloped pulse. The communication link uses an avalanche photodiode module as the receiver. The bit error rate of a 5.4 × 10−6 by 450-nm blue laser diode in turbid water with 1.4 Nephelometric Turbidity Unit was below the forward error correction limit. Our demonstrated underwater wireless laser communication system is simple to use and maintains a high data transmission rate.
Meeting the Needs of Children with Autistic Spectrum Disorders in the Early Years
Authors: Jordan Rita
Published: March 2019

The spectrum of autistic disorders is now known to be far more prevalent than previously thought and diagnosis is being made at earlier ages. There is also a consensus that early intervention and support can have a significant impact on the quality of life for individuals and their families. This presents the problem of how to organise effective education and support in the early years. This paper analyses some of these issues and makes the case for considering a principled eclectic approach, including the best aspects of some specialist approaches, to meet these very individual needs.
Safe Play Areas for Prevention of Young Children Drowning in Farm Dams
Authors: Depczynski Julie , Fragar Lyn , Hawkins Antonia , Stiller Laurence
Published: March 2019

INJURIES ARE THE LEADING cause of death to young children in rural Australia, with drowning in farm dams being a major risk. This paper assesses the impact of an intervention to increase safe play areas on farms to prevent unsupervised access by young children to water bodies and other hazards.

Surveys of 1,117 adult farmers attending Ag Quip Agricultural Field Days in NSW between 2003 and 2007 were used to identify the child security level of fences and changes in the percentage of farms with fenced house yards. Over this four-year period, the percentage of people who had a fenced yard on their farm ranged from 75 per cent to 79 per cent with no significant fluctuations. However, those with a safe play area who stated the area was difficult/almost impossible for a child 0-5yrs to breach, ranged from 40 per cent to 55 per cent over the period, with a statistically significant positive trend (X2=13.46 df=4 p≤.01). Actions to improve child safety on farms and recall of child farm safety messages in the media in association with programs promoting securely fenced house yards are also discussed. In order to affect further reduction in child drowning incidents, there is an ongoing need to promote improved security of fenced house yards on farms in Australia.
The Victorian Early Years Learning and Development Framework: Managing Change in a Complex Environment
Authors: Garvis Susanne , Pendergast Donna , Twigg Danielle , Flückiger Bev , Kanasa Harry , Phillips Carmel , Bishop Maggie , Lockett Kerryn , Leach Darlene
Published: March 2019

THIS ARTICLE REPORTS ON an Educational Change Model originally developed for the middle years of schooling (Pendergast et al., 2005) and applied here to an Australian early childhood education reform initiative. The Victorian Early Years Learning and Development Framework (VEYLDF) was released in 2009 (DEECD & VCAA, 2009). Implementation of the VEYLDF was accompanied by a three-stage independent evaluation on early childhood professionals perceptions of implementation. According to the Educational Change Model, three distinct phases can be identified as individuals and groups move towards full implementation of reforms. The phases are: Initiation, Development, and Consolidation.

Evaluation of initiatives delivered in the implementation of the VEYLDF against key elements of the Educational Change Model revealed that: critical model elements of visioning, policy development, stakeholder engagement and information dissemination were achieved at a high level; resources were developed for early childhood professionals to implement in a range of formats and mediums; the importance of leadership in educational change was recognised in the VEYLDF implementation; inhibitors and enablers to the implementation of the VEYLDF were identified in anticipation of the Development phase of the Educational Change Model.

• The staged implementation of the VEYLDF provided opportunities for progressive feedback on implementation successes and challenges.
The Tensions between Food Choices and Sustainable Practices in Early Childhood Centres
Authors: Boyd Wendy
Published: March 2019

THIS STUDY EXPLORED HOW educators implement policies that support children's health and wellbeing, and that promote sustainable practices in five Australian early childhood (EC) centres. In early childhood centres where parents provide the food, educators are responsible for supervising children's eating and often have to manage children's food that is highly processed and packaged. Interview data from children, parents and educators from five EC centres where parents provide children's food was analysed. The key findings demonstrate that the differing perspectives by the educators, parents and children produced challenges for enactment of healthy food choices and sustainable practices, even though EC centres sought advice from government agencies. Parents' food decisions were often misaligned with centre policies and children were frequently caught between the EC centre's policies and parents' choices of food. Educators felt ineffective influencing parents' food choices and sustainable practices regarding waste minimisation. A holistic educational approach is required where all stakeholders have social responsibility towards this approach.
An Analysis of Young Children's Engagement with Single and Group Interview Methods
Authors: Ey Lesley-anne
Published: March 2019

SEEKING CHILDREN'S PERSPECTIVES regarding matters that concern them is widely accepted and practised among researchers. Despite this, literature on research methods with young children is inconsistent. This paper reports on an analysis of semi-structured, single and group interviews conducted with six-year-old children over two visits to six diverse schools in an Australian state capital city. The findings highlighted that six-year-old children understood their role in the research process and sustained active engagement for lengthy amounts of time. This article highlights the need for researchers to critically evaluate their perspectives of children's capacity to participate in research. If researchers position children as disproportionately vulnerable, their voice could be restricted. Providing children every opportunity to express their perspectives in interviews is paramount, therefore the author presents considerations for best practice.
Diterpenoid Alkaloids from Aconitum Longzhoushanense
Authors: He Ping , Jian Xi-Xian , Chen Dong-lin , Wang Feng-Peng
Published: March 2019

A new aconitine-type C19-diterpenoid alkaloid, longzhoushansine (1), along with fourteen known alkaloids, were isolated from the roots of Aconitum longzhoushanense. Their structures were established by spectral analysis and chemical methods.
Simultaneous Quantification of Eight Major Bioactive Phenolic Compounds in Chinese Propolis by High-Performance Liquid Chromatography
Authors: Sha Na , Huang Hui-Lian , Zhang Jin-Qiang , Chen Guang-Tong , Tao Si-Jia , Yang Min , Li Xing-Nuo , Li Ping , Guo De-An
Published: March 2019

A simple, sensitive and specific high-performance liquid chromatography-UV (HPLC-UV) method has been developed to simultaneously quantify the eight major bioactive phenolic compounds in Chinese propolis, namely caffeic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin 5-methyl ether, pinocembrin, benzyl caffeate, chrysin and galangin. This HPLC assay was performed on an Agilent Zorbax Extend-C18 (250 × 4.6 mm, 5 μm) column with a gradient of methanol and 0.2% aqueous acetic acid (v/v) in 50 min, at a flow rate of 1.0 mL/min, and detected at 290 nm. All calibration curves showed good linearity (r2 >0.999) within the test ranges. The intra- and inter-day assay precision (RSD) of eight phenolic compounds were in the range of 0.07-4.92%. The recoveries were between 98.3% and 104.8%. This assay was applied to the evaluation of nineteen samples from different origins in China. The results indicated that the developed assay could be readily utilized for the quality control of propolis.
The Effect of Temperature on the Essential Oil Components of Salvia potentillifolia Obtained by Various Methods
Authors: Öztürk Mehmet , Tel Gülsen , Duru Mehmet Emin , Harmandar Mansur , Topçu Gülaçtı
Published: March 2019

The chemical compositions of the essential oils of Salvia potentillifolia (Lamiaceae) were analyzed by GC and GCMS. The oils were obtained by four different methods (hydrodistillation, steam distillation, and two extraction methods) to investigate the effect of temperature on the volatile compounds. In total, 121 components were detected in the various oils. The major compounds characterized were α-pinene (30.2, 31.2, 10.6, and 14.8 %) and β-pinene (15.0, 14.6, 7.6, and 11.4%), respectively. Surprisingly, the percentage concentrations of α-pinene and β-pinene in the hydrodistilled and steam distilled oils were high, even though prepared at high temperature, whereas the contents of both compounds were lower in the essential oils obtained by the extraction methods prepared without added heat. The percentage concentration of 8,13-epoxy-labda-14-en-2-one, a diterpenoid, in the extracted essential oil was 22 times higher than in the hydrodistilled and steam distilled essential oils. However, the concentrations of cis-p-menth-2-en-1-ol was four times, and β-bourbonene and β-caryophyllene two times superior than their percentage concentrations in the hydrodistilled and steam distilled essential oils.
Pancreatic Lipase Inhibitory Alkaloids of Murraya koenigii Leaves
Authors: Birari Rahul , Roy Somendu Kumar , Singh Anubha , Bhutani Kamlesh Kumar
Published: March 2019

In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro. All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, koenigicine and clausazoline-K, with IC50 values of 17.9 μM, 168.6 μM, 428.6 μM and ≤500 μM, respectively. This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants.
A Protocol for HPLC-based Activity Profiling for Natural Products with Activities against Tropical Parasites
Authors: Adams Michael , Zimmermann Stefanie , Kaiser Marcel , Brun Reto , Hamburger Matthias
Published: March 2019

HPLC based activity profiling is an effective strategy to accelerate the discovery of new hits and leads from nature. It conveniently combines the superior separation power of HPLC micro scale compound separation with miniaturized biological screening methods, and on-line and off-line spectroscopy (PDA, MSn, HR-MS, NMR) for structure elucidation. We here describe a protocol for the discovery of natural products with antimalarial, antileishmanial and antitrypanosomal activity, from extracts libraries in 96-well format. Analytical gradient HPLC on a 3 × 150 mm column of 350 μg of extract, and collection of one-minute fractions into 96 deep-well microtiter plates, parallel evaporation of the micro-fractions, and a suitable dilution scheme permitted parallel activity profiling against three parasites from a single HPLC injection. The protocol was validated with extracts and positive controls such as Artemisia annua.
Chemical Constituents of Cichorium intybus and their Inhibitory Effects against Urease and α-Chymotrypsin Enzymes
Authors: Saied Sumayya , Shah Shazia , Ali Zulfiqar , Khan Ajmal , Marasini Bishnu P. , Choudhary Muhammad Iqbal
Published: March 2019

Phytochemical investigation of the aerial parts of Cichorium intybus L. resulted in the isolation and identification of two new natural metabolites, 2,6-di[but-3( E)-en-2-onyl]naphthalene (1), and 3,3′,4,4′-tetrahydroxychalcone (2), along with nine known compounds. Their structures were determined by spectroscopic techniques including 1D and 2D NMR. The known compounds were identified as scopoletin (3), 4-hydroxyphenylacetic acid (4), 3-hydroxy-4-methoxybenzoic acid (5), 4,4′-dihydroxychalcone (6), 6,7-dihydroxycoumarine (7), 1-triacontanol (8), lupeol (9), β-sitosterol (10), and β-sitosterol-3- O-β-glucopyranoside (11). Compounds 4-6 and 8 are reported for the first time from C. intybus. Compounds 2 and 3 showed weak inhibitory activities against urease and α-chymotrypsin enzymes, respectively.
Antimicrobial Chemical Constituents from the Endophytic Fungus Phomopsis sp. from Notobasis syriaca
Authors: Hussain Hidayat , Tchimene Michel Kenne , Ahmed Ishtiaq , Meier Kathrin , Steinert Michael , Draeger Siegfried , Schulz Barbara , Krohn Karsten
Published: March 2019

Phomosine K (1), a new phomosine derivative, has been isolated from Phomopsis sp., in addition to six known compounds: phomosine A (2), phenylalanine amide (3), 2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-en (4), (-)-phyllostine (5), (+)-epiepoxydon (6), and (+)-epoxydon monoacetate (7). Preliminary studies showed that compound 1 had strong antibacterial activity, while compounds 4-7 showed good antifungal, antibacterial, and algicidal properties, except compounds 4 and 6, which lacked antifungal activity.
The Construct Validation of the Math Anxiety Scale for Teachers
Authors: Ganley Colleen M. , Schoen Robert C. , LaVenia Mark , Tazaz Amanda M.
Published: March 2019

Past research indicates that teacher math anxiety is related to student outcomes and can be decreased through intervention. However, there is little research on this topic, partially due to a lack of math anxiety measures validated for use with practicing teachers. In this study of 399 elementary school teachers, we report on the construct validation of the Math Anxiety Scale for Teachers. Factor analyses support a distinction between components of general math anxiety and anxiety about teaching math. Math anxiety scores correlate with other teacher characteristics in expected ways: higher math anxiety is associated with lower mathematical knowledge for teaching, more traditional beliefs about math teaching and learning, being a lower elementary school teacher, and a lack of math-specific teaching credentials. The 15-item Math Anxiety Scale for Teachers can be administered efficiently in large-scale studies and may support advances in research exploring relations among practicing teachers’ math anxiety, instruction, and student learning.
Correction to: Following in their footsteps: an analysis of the impact of successive migration on rural household welfare in Ghana
Authors: Egger Eva-Maria , Litchfield Julie
Published: March 2019

The original version of this article [1] has been published with an incorrect copyright holder and license text.
DMM Prize 2018 winner: Wenqing Zhou
Authors: Justice Monica J.
Published: March 2019

Disease Models & Mechanisms (DMM) is delighted to announce that the winner of the DMM Prize 2018 is Wenqing Zhou, for her paper entitled ‘Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish’ (Zhou et al., 2018a). The prize of $1000 is awarded to the first author of the paper that is judged by the journal's editors to be the most outstanding contribution to the journal that year. To be considered for the prize, the first author must be a student or a postdoc of no more than 5 years standing.
SEROLOGICAL AND IMMUNOLOGICAL STUDY OF A FOOT - AND - MOUTH DISEASE VIRUS STRAIN, TYPE 0,WHICH CAUSED AN EPIZOOTIC IN EVROS DEPARTMENT IN 1972
Authors: ΜΠΡΟΒΑΣ Δ. , ΠΑΠΠΟΥΣ Χ.
Published: March 2019

The Foot — and — Mouth Disease (FMD) virus strain, type O, which caused an epizootic in cattle of Peplos community in the Evros Department, near the turkish border, at the end of November 1972 (Strain Ο Peplos/72) was compared with the Dutch strain Ox used for the production of stock vaccines. Besides the strain Ο Peplos/72 was compared serologically with the strain Ο Ferrai/67 which had previously caused an epizootic in the same area. For the serological study the microtechnique of complement fixation described by Darbyshire, Hedger and Ann Arrowsmith and modified by Forman was applied. The value (R) between the strain O, Peoplos/72 and Ο Holland was 30%. The respective value between the strains Ο Peplos/72 and Ο Ferrai/67 was 50%. The immunological study was carried out on guinea - pigs using experimental vaccines prepared from virus grown on BHK cells. The immunological relationship between the stains Ο Peplos/72 and O, Holland was 24%. According to the biomathematical system of dominance (D) proposed by Stellmann et alt. the strain Ο Peplos/72 appears to dominate both over O, Holland and 0 Ferrai 67 giving values D 1.183 and 1.424 respectively. The above data and the observations in the field justifie the use of the strain Ο Peplos 72 for vaccine production.
BIOTIN DEFICIENCY IN TURKEY POULTS
Authors: ΔΕΣΠΟΤΟΠΟΥΛΟΣ Α. , ΔΕΜΕΡΤΖΗΣ Π. , ΜΑΓΚΟΥΤΑΣ Π.
Published: March 2019

An outbreak of leg weakness in turkey poults of the Larissa district (Central Greece) is described. Turkey poults at the age of on3 week were affected, the symptoms being more severe in male than in female. Chemical analysis of the used food disclosed low biotin content. Biotin addition to the food or drinking water prevented further cases. Tne increased needs for biotin in new breeds of turkeys are discussed under the light of recent knowledge on the subject.
VIRUS ABORTION OF MARES
Authors: ΣΕΪΤΑΡΙΔΗΣ Κ. , ΡΑΝΤΣΙΟΣ Α. , ΤΣΑΓΓΑΡΗΣ Θ. , ΟΜΗΡΟΣ Α.
Published: March 2019

A case of virus abortion in mares is described. The diagnosis is based upon the presence of eosinophilinic inclusions in the bronchial epithelium and the hepatic cells as well as in the presence of Herpes virus antibodies. The mares which gave birth to which died alter a few to 96 hours with central nervous system symptoms (excitation - depression) have had a normal pregnancy (333, 75 ± 2,31 days). The mares were presenting also symptoms of vesicular coital exanthema
A CASE OF DERMATITIS IN PIGLETS
Authors: ΣΤΟΦΟΡΟΣ Ε. , ΡΑΝΤΣΙΟΣ Α. , ΜΑΣΤΡΟΓΙΑΝΝΗ-ΚΟΡΚΟΛΟΠΟΥΛΟΥ Μ.
Published: March 2019

The authors describe a case of dermatitis in piglets. The histological findings (presence of eosinophilinij polynucleatei cells in the skin) and the impossibility of isolating a pathological agent suggest an allergic etiology of this dermatitis.
DIGESTIVE AND RESPIRATORY DISORDERS WITH INTRANUCLEAR INCLUSION BODIES IN TWO CALVES
Authors: ΠΑΠΑΔΟΠΟΥΛΟΣ Χ. , ΣΙΜΟΣ Ε.
Published: March 2019

The authors give a cytological description of liver and kidneys from two cal ves with digestive and respiratory troubles. Characteristic spherical nuclear inclusions were noticed. In one calf nuclear inclusion were noticed. In the other calf acidophilic nuclear inclusions were found in the kidneys •capillary endothelium especially in the cortex and partial vacuolated degeneration in the myocardial fibres.
Do Hospitals Participating in Accountable Care Organizations Discharge Patients to Higher Quality Nursing Homes?
Authors: Bain Alexander M , Werner Rachel M , Yuan Yihao , Navathe Amol S
Published: March 2019

We examined whether hospitals participating in Medicare's Shared Saving Program increased the use of highly rated skilled nursing facilities (SNFs) or decreased the use of low‐rated SNFs hospital‐wide after initiation of their accountable care organization (ACO) contracts compared with non‐ACO hospitals. Using a difference‐in‐differences design, we estimated the change in the probability of discharge to 5‐star and 1‐star SNFs among all beneficiaries discharged from ACO‐participating hospitals after the hospital initiated ACO participation. After joining an ACO, the percentage of hospital discharges going to a high‐quality SNF increased by 3.4 percentage points on a base of 15.4% (95% confidence interval [CI] 1.3‐5.5, P = .002) compared with non‐ACO‐participating hospitals. The probability of discharge from an ACO‐participating hospital to low‐quality SNFs did not change significantly compared with non‐ACO‐participating hospitals. Our findings indicate that ACO‐participating hospitals were more likely to discharge patients to highly rated SNFs after they began their ACO contract but did not change the likelihood of discharge to lower rated SNFs in comparison with non‐ACO hospitals.
Atividade física e dor lombar em brasileiros: uma revisão sistemática
Authors: Polli Gabriela Ribeiro , Falqueto Hugo , Czarnobai Izadora , Christofaro Diego Giulliano Destro , Guerra Paulo Henrique
Published: March 2019

O objetivo deste estudo é identificar e sumarizar os estudos observacionais conduzidos em território brasileiro que avaliaram as possíveis associações entre a prática de atividade física (AF) e a dor lombar (DL), bem como analisar seus métodos. Para isto, foram realizadas buscas em cinco bases de dados eletrônicas (Lilacs, Pubmed, Scielo, Sportdiscus e Web of Science), além de buscas manuais nas listas de referências. Foram incluídos estudos observacionais desenvolvidos em território brasileiro, sem restrições quanto à idade, que apresentaram análises de associações entre AF e DL, disponíveis até 10 de outubro de 2017. Dos 153 estudos inicialmente recuperados, 11 compuseram a síntese descritiva (sete deles envolvendo adultos). Das 14 análises de associação recuperadas, apenas uma apresentou associação de risco entre a prática excessiva de AF e DL, em adolescentes. A presente síntese aponta para a necessidade de importantes avanços metodológicos nos futuros estudos, tais como: a necessidade da realização de estudos longitudinais; a investigação de possíveis relações entre distintos domínios da AF e diferentes tipos de DL; a necessidade de padronização nos pontos de corte utilizados pelos instrumentos para determinar AF suficiente e a prevalência da DL; e a utilização de medidas objetivas, em paralelo ao questionário, para avaliação da AF.
INTERCULTURALIDADE CRÍTICA: APRENDER A DECOLONIZAR A EDUCAÇÃO COM SABERES DE MULHERES RIBEIRINHAS DA AMAZÔNIA
Authors: Tavares Neri Isabell Thereza , Oliveira Ivanilde Apoluceno de
Published: March 2019

Neste artigo analisa-se os saberes de mulheres em tratamento hospitalar, vítimas de escalpelamento nos rios da Amazônia ou acompanhantes, e que frequentam, em um espaço de acolhimento, uma classe hospitalar. Este estudo consiste em um recorte de uma pesquisa, concluída em 2018, financiada pela FAPESPA, realizada em um ambiente hospitalar, em que se desenvolve uma educação intercultural crítica freireana, que fomenta o empoderamento das mulheres ribeirinhas por meio do reconhecimento de suas vozes, saberes, práticas e manifestações culturais. É uma pesquisa de campo qualitativa com os seguintes procedimentos metodológicos: levantamento bibliográfico e documental, entrevistas com 15 mulheres de faixas etárias variadas, oriundas de diferentes comunidades ribeirinhas da Amazônia Paraense e observação participante. Entre os resultados destaca-se que a aprendizagem se dá por meio de narrativas das mulheres sobre o “enfrentamento da violência de gênero”, o “trabalho”, a “medicina popular” e o “imaginário”, que fazem parte do contexto de diversidade biossocial e cultural das comunidades ribeirinhas da Amazônia.
Cutaneous sun damage and skin protection: a focus on FiltaClear
Authors: Paterson Sue
Published: March 2019

Phototoxicity (sunburn) and photosensitivity are the two most important forms of sunlight induced disease recognised by veterinary surgeons in the dog, cat and horse. Phototoxicity is mediated by UVB radiation and has a spectrum of presentations, ranging from sunburn to more severe actinic damage and squamous cell carcinoma. Phototoxicity is usually seen on white or non-pigmented skin, especially where there is little hair covering, and is recognised in all three species. Photosensitisation is most commonly seen in the horse and represents an abnormal reaction of the skin to light, caused by photodynamic agents in or on the skin. Sun avoidance and sun protection are important in all of the domestic species, to prevent sunlight induced disease.
Effect of tibial component alignment on knee kinematics and ligament tension in medial unicompartmental knee arthroplasty
Authors: Sekiguchi K. , Nakamura S. , Kuriyama S. , Nishitani K. , Ito H. , Tanaka Y. , Watanabe M. , Matsuda S.
Published: March 2019

Objectives

Unicompartmental knee arthroplasty (UKA) is one surgical option for treating symptomatic medial osteoarthritis. Clinical studies have shown the functional beneﬁts of UKA; however, the optimal alignment of the tibial component is still debated. The purpose of this study was to evaluate the effects of tibial coronal and sagittal plane alignment in UKA on knee kinematics and cruciate ligament tension, using a musculoskeletal computer simulation.

Methods

The tibial component was first aligned perpendicular to the mechanical axis of the tibia, with a 7° posterior slope (basic model). Subsequently, coronal and sagittal plane alignments were changed in a simulation programme. Kinematics and cruciate ligament tensions were simulated during weight-bearing deep knee bend and gait motions. Translation was defined as the distance between the most medial and the most lateral femoral positions throughout the cycle.

Results

The femur was positioned more medially relative to the tibia, with increasing varus alignment of the tibial component. Medial/lateral (ML) translation was smallest in the 2° varus model. A greater posterior slope posteriorized the medial condyle and increased anterior cruciate ligament (ACL) tension. ML translation was increased in the > 7° posterior slope model and the 0° model.

Conclusion

The current study suggests that the preferred tibial component alignment is between neutral and 2° varus in the coronal plane, and between 3° and 7° posterior slope in the sagittal plane. Varus > 4° or valgus alignment and excessive posterior slope caused excessive ML translation, which could be related to feelings of instability and could potentially have negative effects on clinical outcomes and implant durability. Cite this article: K. Sekiguchi, S. Nakamura, S. Kuriyama, K. Nishitani, H. Ito, Y. Tanaka, M. Watanabe, S. Matsuda. Bone Joint Res 2019;8:126–135. DOI: 10.1302/2046-3758.83.BJR-2018-0208.R2.
Bullying homofobikoari buruzko aurrezagutzak
Authors: Zarraga Amets , Tejada Eneko , López de la Serna Arantzazu , Bilbao Naiara
Published: March 2019

ABSTRACTBullying is a current problem that occurs in education and has recently become extremely important for society. However, homophobic bullying has not been given the importance it should have. This one, refers to the harassment that is suffered by sexual orientation or condition, sometimes being the reason for such negative behaviors. Therefore, with this research work, by quantitative study, it has been analyzed the knowledge that primary education teachers have on this matter. The inormation received shows that education professionals have a general idea of the subject, but exposes the lack of precision about homophobic bullying.KEYWORDS: bullying, homophobic bullying, preconceptions.LABURPENABullying-a eskolan errepikatua izan den eta azken aldian gizartearentzat garrantzia duen arazoa da. Eskola jazarpena duen aldaeretako bati, hots, bullying homofobikoari oraindik ez zaio behar besteko garrantzia eman. Azkeneko honek, ikasle batzuek bullying-a orientazio edo baldintza sexualarengatik sufritzen duten erasoei erreferentzia egiten dio, jokaera negatiboen arrazoia delarik. Hortaz, ikerketa lan honen bitartez, Lehen Hezkuntzako bost ikastetxeetako irakasleriak problematika honen inguruan duen ezagutza maila aztertu da. Ikerketan jasotako datuek, hezkuntzako profesionalek gaiaren inguruan ideia orokor bat dutela adierazi duten arren, bullying homofobiko kontzeptuaren inguruko zehaztapenak falta zaizkiela jaso da emaitzetan.GAKO-HITZAK: eskola jazarpena, bullying homofobikoa, aurreiritziak.