bluuebunny/crossref_metadata_2025 huggingface dataset:
Torbangun (Plectranthus amboinicus (Lour.) Spreng) Leaf Extract Upregulates Expression of Lactation-Related Genes in Human Mammary Epithelial Cells MCF-12A
Authors: Tafzi Fitri , Andarwulan Nuri , Giriwono Puspo Edi , Dewi Fitriya N
Published: January 2025

Torbangun (Plectranthus amboinicus (Lour). Spreng) leaf is a herbaceous plant capable of increasing breast milk, although the mechanism of bioactive compounds on the molecular level remains relatively unknown. Therefore, this study aimed to evaluate the effect of torbangun leaf extract on the expression of genes associated with alveologenesis and the formation of milk protein, namely prolactin receptor (PRLR), glucocorticoid receptor (GR), signal transducer, as well as activator of transcription 5A (STAT5A) and b-casein (CSN2). The result showed that the extract and fractions of torbangunleaf had IC50 values above 20 ug/ml against MCF-12A cells. Ethyl acetate fraction also enhanced the expression of gene GR, STAT5A, and CSN2. Water fraction of torbangun leaf enhanced expression of gene PRLR, GR, STAT5A, and CSN2. The bioactive compound was found to increase the expression of genes associated with proliferation, alveologenesis, and the formation of milk protein during gestation and lactation.
El accionar político de ANDE en Costa Rica durante ochenta años de historia: una propuesta de análisis tipológico
Authors: Arias-Angulo José Miguel
Published: January 2025

El objetivo de este artículo es identificar las acciones políticas que la Asociación Nacional de Educadores y Educadoras (ANDE) ha realizado desde su surgimiento hasta el presente. La discusión teórica ubica a esta agrupación como una organización que ejerce presión sobre los poderes gubernamentales para cumplir sus fines. Como parte del planteamiento teórico, se aborda conceptos como grupos de presión, sindicato y movimientos sociales, además de los de política, poder, cultura y acción política. La metodología se centra en la construcción de una tipología que clasifica las acciones en seis tipos diferentes. El hallazgo principal es que las acciones varían según el contexto nacional. Desde la década de 1980 se adoptaron formas y repertorios confrontativos, al tiempo que las acciones de propuesta y negociación, que antes predominaban, han disminuido. Esto se explica por el cambio de modelo de Estado, la adopción de políticas neoliberales y la ineficacia del diálogo para llegar a acuerdos. Debido a la constancia de su accionar y los logros alcanzados, se concluye que ANDE constituye un actor influyente en la historia de Costa Rica.
Transdisciplinary environments of learning: an initial proposal
Authors: Cirino de Mattos Max , Maria Abrantes Baracho Renata
Published: January 2025

Over the past decade, we have developed and implemented a simpler Design Science Research (DSR) approach for undergraduate and graduate courses in Administration, Information Science, and Architecture, exploring the potential of transdisciplinary learning environments in both the academic and professional spheres. We have named this approach Transdisciplinary Environments of Learning (TEL) and it is based upon the concept of a complex, presented by Bogdanov – a Russian philosopher highly concerned with the “language of science”. This paper presents the foundational concepts of TEL, a proposed methodology composed of two artifacts: TELsteps and TELdict. The first one, adapted from DSR, provides a structured approach to the design and implementation of TEL, and has four steps: (1) defining the goal, (2) developing the artifact, (3) validating its efficacy, and (4) disseminating the knowledge created. TELdict offers an initial lexicon of relevant terms, concepts, and definitions: abstraction, analogy, artifact, diagram, generalization, informational complex, inner environment, methodological procedure, outer environment, and research methodology. Together, these two artifacts offer an integrated and comprehensive approach to address two major issues faced when establishing a transdisciplinary environment: methodology and language. For TEL, it is not required for the domains to change their methodology, but rather to analyze their results using a common methodology and language. This paper explores the initial concepts of TEL and provides basic steps for facilitating the creation of knowledge among diverse areas. Future research will further investigate and discuss these concepts in greater detail. Ongoing research at LATACI® Research Institute is developing the Relational Model of Informational Complexes (RMIC), exploring rules for diagram design.
Taxonomia de Problemas em Design para a Saúde
Authors: Pötter Rafaela , Fischer Brendler Clariana , Gonçalves Teixeira Fábio
Published: January 2025

Este artigo expõe e documenta o desenvolvimento de uma taxonomia para a classificação de problemas em Design para a Saúde. Sabe-se que as áreas do design e da saúde são distintas quanto às formas de produção de conhecimento e de atuação, mas, também, que são complementares, uma vez que o design tem potencial de resolução de problemas complexos. Assim como a procura por conhecimentos específicos do design por parte de instituições e profissionais da saúde, a pesquisa em Design para a Saúde (DPS) está em evidência nos últimos anos, sendo tema central de periódicos e grupos de pesquisa em diferentes países, com destaque para assuntos como produtos de tecnologia assistiva, acessibilidade e desenvolvimento de produtos em geral. Contudo, lacunas podem ser percebidas quanto ao desenvolvimento da temática: as produções são, na sua maioria, independentes, nem sempre são vinculadas ao Design para a Saúde, e, além disso, há pouca literatura que embase a temática, não estando claramente estabelecidas as relações entre as áreas. Como forma de contribuir para a consolidação do DPS como grande área de concentração de pesquisa, desenvolveu-se uma taxonomia fundamentada no sistema de classificação facetada e nos Níveis de Atenção à Saúde que baseiam a organização dos serviços do Sistema Único de Saúde (SUS). Como procedimentos metodológicos, adotou-se a pesquisa bibliográfica e duas Revisões Sistemáticas da Literatura para o mapeamento de termos, e um passo-a-passo específico elaborado para a construção da proposta de classificação. Ao final, é apresentada como resultado a Taxonomia de Problemas em Design para a Saúde, um sistema de classificação com quatro classes principais desdobradas em subclasses e renques que delineiam o problema conforme Ordem, Público-alvo, Local de ocorrência e Tipo de atendimento. Espera-se que a taxonomia esclareça as relações entre design e saúde, contribua para a unificação da pesquisa na área do DPS e, além disso, seja ferramenta empregada por designers e pesquisadores para clarificar os problemas e auxiliar no planejamento metodológico da problematização.
Proposta de um Software para um Restaurante Universitário utilizando a metodologia Design Centrado no Usuário
Authors: Belisario Luiz Fernando Barboza , Santos Silva Luan Carlos
Published: January 2025

O restaurante universitário (RU) de universidades públicas, em especial o da Universidade Federal da Grande Dourados (UFGD) é uma iniciativa importante para fornecer refeições acessíveis aos estudantes e à comunidade acadêmica, promovendo a igualdade social e contribuindo para a permanência dos alunos na universidade. Com o objetivo de aprimorar a gestão e a experiência dos usuários neste ambiente, propõe-se o desenvolvimento do "Menu Acadêmico", um software centrado no usuário. O problema de pesquisa aborda como a aplicação de tecnologias da informação pode melhorar a experiência dos usuários do restaurante universitário, visando aumentar a satisfação e eficiência no acesso aos serviços oferecidos. O objetivo desta pesquisa consistiu em desenvolver um software para o RU da UFGD, aplicando a metodologia Design Centrado no Usuário (DCU) para atender às necessidades dos usuários de forma eficaz. O estudo baseia-se em uma abordagem qualitativa, combinando pesquisa bibliográfica, documental e estudo de campo. Seguindo as etapas da metodologia DCU, foram coletados dados, analisadas informações e geradas soluções para melhorar o software proposto, com foco na experiência do usuário. O "Menu Acadêmico", desenvolvido em 2023, é uma inovação que otimiza processos no RU da UFGD, refletindo o compromisso com a excelência e satisfação dos usuários. O software desenvolvido está disponibilizado de forma gratuita para que outras universidades públicas brasileiras possam conhecer suas funcionalidades, utilizar para melhorar a gestão dos restaurantes e o relacionamento com os usuários.  A aplicação das fases do DCU garantiu a consideração das necessidades dos usuários desde a concepção do software. Com isso, o estudo contribui para avançar nas fases subsequentes da metodologia DCU, além de fornecer uma base para futuras pesquisas na área de tecnologia aplicada à gestão de restaurantes universitários brasileiros. Tecnologicamente, oferece uma comunicação mais eficaz com os usuários, uma experiência aprimorada e oportunidades contínuas de melhoria com base no feedback dos usuários e na análise de dados. Sua implementação trará benefícios imediatos e oportunidades futuras de aprimoramento contínuo.
Alfa Libras 3D: Uma Ferramenta Inclusiva para Auxiliar na Aprendizagem da Língua Brasileira de Sinais
Authors: Viana Emanueli da Silva , Santos Deborah Macedo
Published: January 2025

As políticas públicas de inclusão permitiram um notório crescimento da quantidade de pessoas com deficiência nas universidades brasileiras, mas ao chegarem lá estas pessoas têm encontrado dificuldades no aprendizado, em parte por causa da carência de materiais pedagógicos adaptados que as auxiliem na aprendizagem das mais diversas áreas do conhecimento. Esta investigação apresenta o desenvolvimento do projeto Alfa Libras 3D: Uma ferramenta inclusiva para auxiliar na aprendizagem da Língua Brasileira de Sinais, que teve como motivação inicial a identificação da problemática da falta de materiais pedagógicos que auxiliassem no ensino e aprendizagem da Língua Brasileira de Sinais (LIBRAS), para um aluno com deficiência visual que teria se matriculado na turma desta disciplina (LIBRAS) na universidade em que estuda, ainda no período de aulas remotas emergenciais por conta do cenário pandêmico. A metodologia utilizada no desenvolvimento desta investigação tem cunho experimental com elaboração de protótipos, que foram desenvolvidos por meio da fabricação digital com auxílio de impressoras 3D como alternativa para criação de elementos táteis. Diversos testes de modelagem e digitalização foram realizados até que se chegasse no melhor meio de modelo virtual, para seguir com a prototipagem física dos objetos. Como resultado do projeto apresentam-se 26 peças no formato de cards referentes as letras do alfabeto, onde cada peça contém a representação 3D do alfabeto em LIBRAS, braile em alto relevo e o alfabeto romano em baixo relevo. Os produtos Alfa Libras impressos foram validados com um aluno com deficiência visual que conseguiu identificar e reproduzir o sinal sem auxílio da audiodescrição. As peças passaram pela validação de uma professora de LIBRAS do ensino superior, que confirmou a acuidade dos sinais, como também o validou como material a ser utilizadas nas aulas de LIBRAS. O resultado foi exposto ainda para a comunidade científica surda em evento específico, com grande aceitação.
Design e Sistemas Agroecológicos: irrigação, colorantes e projeto de espaços como exemplos de conexão
Authors: Mendonça Rosangela Míriam Lemos Oliveira , Pessoa dos Santos Breno , Monteiro de Barros Filho Roberto , Santos Brandão Marcus Paulo , Bertu Valverde Felipe
Published: January 2025

A agroecologia está cada vez mais difundida, inclusive nos contextos urbanos, em função dos seus diversos benefícios. Neste artigo, abordamos esses benefícios, bem como dificuldades. A metodologia do Design Sistêmico é utilizada para construir uma abordagem para, ao mesmo tempo, identificar e lidar com desafios para o desenvolvimento da agroecologia e ser atrativo ao designer, uma vez que, para o estabelecimento e manutenção de um relacionamento, é necessário haver interesse de ambas as partes. Assim, tratando a questão das formas como o designer pode contribuir com sistemas agroecológicos, exemplificamos aqui a questão da irrigação e a busca de uma solução que seja acessível em relação aos custos, à disponibilidade de materiais e ao domínio das variáveis envolvidas. Para isso apresentamos o tema do uso da água e sistemas de irrigação. Dentre eles selecionamos aquele que melhor atenderia a contextos de escassez de recursos e uso eficiente da água. Desenvolvemos então seis conjuntos de experimentos relacionadas à irrigação frugal por gotejamento, que nos permitiram identificar as variáveis que influenciam no padrão de irrigação para indicar a configuração adequada ao contexto de aplicação. As metodologias de testes foram evoluindo a partir dos resultados de cada bateria. O primeiro bloco de testes utilizou um processo manual, com poucos dados coletados. O segundo já empregou a automatização, com o uso de sensores e Arduíno, o que permitiu a coleta de um número alto de dados que foram apresentados em gráficos. Apresentamos também como o designer tem a ganhar com a agroecologia, evidenciando recursos do contexto da agroecologia que fazem parte de áreas tradicionais de atuação do designer, como as diversas aplicações de colorantes naturais e o planejamento de espaços. Desta forma apresentamos processos, investigações, análises de contextos que venham estimular a parceria entre o Design e a Agroecologia, ambos com grande potencial de imprimir mudanças necessárias à nossa sociedade caminhando para o equilíbrio da sustentabilidade.
Handy home improvements: a proposal for a prototype web application for technical assistance in social housing
Authors: Barbosa Villa Simone , Carrer Ruman de Bortoli Karen , Vasconcelos Oliveira Lamonise
Published: January 2025

In the face of the pressing challenges posed by the COVID-19 pandemic, the role of architects and urban planners in delivering evidence-based technical assistance for social housing (TASH) has become more crucial than ever. This article outlines the stages and methodologies employed in developing a prototype web application titled "Reforma na Palma da Mão" (Handy home improvements). The project was funded by CAU-MG under Public Notice 001/2021, focusing on the theme "Healthy Home – Decent Housing." The characteristics, structure, and proposed graphical interface for the application are highlighted, as designed to provide information on alterations with a focus on functionality and thermal comfort in social housing (SH) units of the Brazilian Minha Casa, Minha Vida (PMCMV) housing program. These are attributes of the built environment most directly associated with health, particularly relevant in the face of the consequences of the COVID-19 pandemic on living conditions – such as the need to study/work from home and the provision of thermal qualities required for the successful execution of these activities in indoor environments. The paper highlights the importance of User-Centered Design (UCD) and Post-Occupancy Evaluation (POE) as methodologies that facilitate the development and web-based delivery of tailored alteration guidance strategies, aligned with the characteristics and needs of the target audience. The article also describes the usability testing process of the proposed application, highlighting its potential for use by wider audiences interested in the construction and alteration of SH. Thus, residents, service providers, and architects and urban planners involved in the production of healthier and more resilient SH units find suctivities through the reported pilot project.
Learning Culture and Organizational Effectiveness in Emerging Market: An Exploratory Study in the Logistics Industry
Authors: Budihardjo Andreas , Supriyadi Franky
Published: January 2025

In a highly uncertain and complex business environment, a learning culture is crucial to be adopted. Undoubtedly, it encourages continuous organizational learning to produce innovative products, services, or systems to achieve high organizational effectiveness. This study aims to explore the extent to which logistics companies adopted the learning organization paradigm to achieve high organizational effectiveness or performance. This study examines the implementation of the organizational learning practices of the medium-sized logistic companies operating for more than five years. By identifying the critical role of organizational learning aspects, such as structure, culture, knowledge management, and technology, corporate leaders would have the clue to manage it effectively resulting in better organizational effectiveness. Data was collected by interviewing senior managers; then it was qualitatively analyzed. The findings indicated that the implementation of organizational learning supported the logistics companies to achieve their performance. However, it was also implied that several organizational learning practices such as knowledge management, training and development, and technology use were not strategically managed. The study provides significant input for logistics companies to improve their organizational learning practices for better performance achievement.
STRATEGI PEMBELAJARAN AGAMA ISLAM BAGI SISWA AUTIS DI SLB NEGERI METRO
Authors: Tisnawati Nina , Islahudin Ahmad Noor , Garianto Garianto
Published: January 2025

This research discusses Islamic religious learning strategies for autistic class students at the Metro State Special School. This research focuses on how appropriate learning strategies can be delivered to autistic students, who have different ways of learning from children in general. This requires teachers to be given appropriate direction and strategies in delivering Islamic religious lessons, which is currently only done once a week by their respective homeroom teachers. Application of learning is an activity carried out by SLB teachers using appropriate methods and utilizing various media for students, with the aim of achieving learning objectives. Islamic religious lessons for autistic students require a special approach so that they can be well received. Emotional approach and demonstration method are some of the effective strategies. Apart from that, religious activities are held on religious holidays, such as daily prayer reading competitions and short letters between students. The aim of this research is to find out how effective Islamic learning strategies are for autistic students, so that the messages conveyed by teachers can be well received by them.
An Updated Review of Sinonasal Inverted Papilloma
Authors: Kashoob Musallam , Alsayed Ahmed
Published: January 2025

This comprehensive review provides an in-depth examination of the multifaceted landscape of Sinonasal Inverted Papilloma (IP). A thorough historical overview traces IP from its initial description in 1850 to contemporary classifications, highlighting evolving understandings. Epidemiology, demographics, and clinical presentations are explored to underscore challenges in diagnosis given symptomatic overlap with other sinonasal conditions. The unique histopathology and embryonic origin of tumors, arising from the Schneiderian membrane, are discussed to elucidate the characteristic inverted growth pattern. Surgical resection, particularly endoscopic approaches, is established as the standard treatment. Innovative surgical methods are considered along with examining influences such as Human Papilloma Virus and recurrence rates. The intricate dynamics of recurrence, follow-up strategies, and the rare but impactful malignant transformation are thoroughly analyzed. The Krouse staging system proves instrumental in predicting recurrence, while advancements in endoscopic techniques offer promising avenues for both diagnosis and treatment. The review has shed light on identifying gaps in understanding immunohistochemical markers and biological mechanisms, emphasizing the imperative need for future research to refine diagnostic precision and therapeutic approaches.
Parents' knowledge, awareness, and timing of repair of congenital umbilical hernias in infants and young children in Al-Qunfudah Governorate, Saudi Arabia
Authors: Salih Mohamed , Mahfouz Huda , Alfaqeeh Ahmad , Alshaeri Laila , Mahfouz Mohsen , Alnashri Amani , Alkhairi Atheer , Al-Masoudi Manar , Alrufaydi Nawaf
Published: January 2025

Objective:
This study aimed to assess parental knowledge, perception, and awareness of congenital umbilical hernias in infants and children, as well as the timing of treatment in Al-Qunfudah Governorate.
Methods:
This observational cross-sectional study was conducted from January to March 2024 through a pretested, structured online questionnaire among 386 participants through convenience sampling techniques. All parents who had children living in the Al-Qunfudah governorate and were willing to participate in the study were included.
Results:
Most participants were within the 18-25 age group (33.70%), females (80.60%), and almost all participants were Saudi nationals (99.00%). Most were married (59.30%), had a bachelor's degree (58.00%). Among affected children, most were infants less than one year (4.70%). Most of the participants reported all of the following: abdominal muscle weakness, abdominal and bariatric surgery, congenital, obesity, chronic constipation, and chronic cough as causes of hernia (50.50%). Despite this awareness, there were gaps in recognizing symptoms. Regarding sources of knowledge about hernia, the majority get the knowledge from healthcare professionals (35.80%). The findings on the timing and indications for umbilical hernia repair showed a general inclination toward intervention.
Conclusion:
The participants in the study exhibited varying levels of awareness and knowledge regarding congenital umbilical hernias. There was general agreement that large hernias, strangulated or incarcerated hernias, and symptomatic hernias should be repaired. There was also support for repairing asymptomatic reducible umbilical hernias by the age of five years if they had not spontaneously closed.
Utilization of herbal and complementary medicine in patients receiving chemotherapy at King Abdulaziz University Hospital in Jeddah
Authors: Alkhayyat Shadi , Alshahrani Bandr , Alkhyal Abdullah , Alothaymin Muath , Essa Bandar , Alanazi Muhannad , Baasher Abdullah , Albakri Mohammed , Alssaggaff Ahmed , Madani Hassan , Bahwal Bakur
Published: January 2025

Objective:
This study aimed to evaluate complementary and alternative medicine (CAM) use among chemotherapy patients at King Abdulaziz University Hospital in Jeddah, Saudi Arabia.
Methods:
A cross-sectional study of chemotherapy patients receiving daycare was carried out at King Abdulaziz University Hospital. Data on patient demographics, smoking status, cancer kind and stage, other cancer treatments, CAM use, and usage patterns were gathered by a questionnaire.
Results:
Of the studied 100 cancer patients, 62% were females, 72% were married, 44% had an educational level higher than secondary school, 71% were unemployed, and 18% had a monthly income >6000 SR. The prevalence of CAM was 72% and 37.5%, 12.5% and 6.9% discussed CAM with their doctors, nurses, and patient's educator respectively. The most commonly used types were Zamzam water (77.7%), Quran recitation (65.2%), and olive oil (55.5%). Immunity enhancement was the most frequent justification for CAM use (95.8%), and 80.6% of users reported an improvement. A non-significant relationship was found between CAM use and patients' demographics or smoking status.
Conclusion:
Zamzam water was the most often utilized CAM, and a significant prevalence of its use was noted among cancer patients. It is advisable to comprehend how CAM might enhance the psychological and bodily traits of cancer patients. To demonstrate strong correlations between CAM use and pertinent parameters, long-term research is needed.
Patterns of hepatitis B infection serological markers in the southwestern region of Saudi Arabia: a three-year retrospective study
Authors: Alhazmi Abdulaziz , Gharawi Amal , Almalki Abdullah , Hakami Ehab , Jafar Rafaa , Mobarki Hanin , Madkhali Mohammed , Koriri Megali , Shiwani Hussain , Hamzi Tareq , Moftah Abdullah , AlQassem Anees , Matabi Abdullatif , Alameer Mazen , Melaisi Zakaria
Published: January 2025

Objective:
This study aimed to analyze the demographic characteristics, serological markers, and temporal trends of HBV infection among patients at a tertiary hospital in Jazan, Saudi Arabia, over three years.
Methods:
This retrospective study utilized patient data collected from the years 2021 to 2023. Partic-ipants were identified based on a positive hepatitis B surface antigen (HBsAg) result. Addi-tional demographic details and HBV serological markers, including HBeAg, HBeAb, HBcIgM, and HBcIgG, were recorded.
Results:
Among 43,763 samples received, a total of 1,858 participants tested positive for HBsAg (0.5%), with a male predominance (56.6%), 83.9% being Saudi nationals, and 77.2% aged over 40 years. Active HBV replication, indicated by HBeAg positivity, was observed in 2.6% of cases and was significantly associated with younger age (p-value= 0.011), with the highest replication rates recorded in the year 2021 (50%, p-value= 0.005).
Conclusion:
This study provided an updated understanding of HBV infection dynamics in Jazan, showing a low HBsAg prevalence in the region, likely reflecting the impact of vaccination programs. However, younger individuals demonstrated more active HBV replication, indicating the importance of targeted interventions for this age group. Additionally, the seasonal peaks in testing suggested that enhanced awareness could improve early detection and management.
Prevalence and risk factors of pediatric constipation in Saudi Arabia: a comprehensive systematic review and meta-analysis
Authors: Alahmari Abdulrahman , Alotaibi Nasser , Alshahrani Abdulmajeed , Alshammari Nouf , Albattat Faisal , Alsharaef Abdulaziz , Alrobeishy Aljohara , Mutar Sajidah , Alghamdi Remas , Alshahrani Najim
Published: January 2025

Functional constipation (FC) is a common pediatric gastrointestinal disorder, that affects children's quality of life and imposes a significant burden on healthcare systems. In Saudi Arabia, where FC is a prevalent concern, understanding its epidemiology and associated risk factors is crucial for targeted interventions. This systematic review and meta-analysis aim to estimate the prevalence of pediatric constipation in Saudi Arabia and identify associated risk factors to inform healthcare strategies. A systematic search was conducted using databases including PubMed, Scopus, Web of Science, and regional sources. Observational studies reporting prevalence and risk factors of constipation in Saudi children aged 0–18 years were included. Data extraction and quality assessment were performed independently by two reviewers using standardized tools. A random-effects meta-analysis was conducted to estimate pooled prevalence rates, with heterogeneity assessed using I² and Cochran's Q test. Risk factors were synthesized qualitatively. Seven studies comprising 12,465 participants were included, with prevalence rates ranging from 4.7% to 32.2%. The pooled prevalence of pediatric constipation was 13% (95% CI: 9.2%–17.8%), with substantial heterogeneity (I²=99%). Common risk factors identified included low maternal age, bottle feeding, low dietary fiber intake, psychological stress, and family history of gastrointestinal conditions. The quality assessment rated four studies as high quality and three as moderate quality. Pediatric constipation in Saudi Arabia affects a substantial proportion of children, with notable regional variations and multifactorial risk factors. The findings underscore the need for early screening and tailored interventions to mitigate long-term complications. Further research is recommended to explore underlying mechanisms and evaluate the effectiveness of preventive strategies.
Prediction of long-term survival in acute aortic dissection by the false lumen condition; systematic review
Authors: Alanazi Mazi , Alkhdidi Enad , Assalahi Yazeed , Alqahtani Ziyad , Najmi Nawaf , Almofdhi Musaed , Noura Rami , Maghrabi Sarah , Alrajeh Mohammed , Algawiz Areej
Published: January 2025

This review aimed to find out how the false lumen status impacted the long-term acute aortic dissection (AAD) patient's outcomes. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed in the conduct of this study. A language-neutral automated search of the PubMed, Cochrane, and Embase databases was carried out between the years 2010 and 2024. Papers analyzing the false lumen state and the risk of long-term outcomes in AAD patients were found using the search terms thrombus, thrombosis, thrombi, clot, false lumen, aortic dissection, and dissection of the aorta. In contrast to full false lumen thrombosis (FLT), the analysis of six original research showed a significant relation between elevated risk of long-term aortic events in patients with AAD type A and B and residual patent false lumen (PFL). Furthermore, compared to a fully PFL, partial FLT seems to be a long-term mortality predictor in type B AAD.
Adherence rates and effectiveness of preventive health screening guidelines in family medicine: systematic review
Authors: Najmi Mahmood , Niyazi Razan , Shamlan Ahmed , Sufyani Hamad , Abdulshakur Ahmed , Alabdullgader Abdulaziz , Nabrawi Sarah , Melebari Dania , Mardhamah Abdulmohsen , Alshuaibi Abdulaziz
Published: January 2025

Preventive health screening is a critical component of family medicine, aimed at early detection and intervention to reduce the burden of chronic diseases. However, adherence to screening guidelines varies widely, influencing their effectiveness. This systematic analysis assessed the effectiveness and adherence rates to preventive health screening guidelines in family practice.
The study searched electronic databases for studies on preventive health screening in family medicine, focusing on adherence to guidelines and their effectiveness. Data extraction focused on study characteristics, adherence rates, and screening outcomes. The quality of the studies was evaluated using standardized criteria, and a narrative synthesis was performed to integrate findings. The findings showed that adherence rates vary significantly (1.1% to 80%), depending on patient demographics, provider characteristics, and healthcare system structures. Improved health outcomes in communities with high adherence helped to support the guidelines' effectiveness. However, there was significant variation among demographic groupings, with lesser adherence reported in minority communities and those with lower socioeconomic status. Patient-related factors (e.g., health literacy) and provider-related ones (e.g., knowledge and time restrictions) both hampered adherences. Despite the usefulness of preventive screening guidelines in improving health outcomes, the study emphasized that adherence remains low in a variety of populations. Future research should focus on designing personalized interventions to address the identified barriers, as well as investigating novel techniques to improve adherence to preventive health screening guidelines in family medicine.
Gastrointestinal Manifestations in Children with Autism Spectrum Disorder (ASD) in Saudi Arabia: a Cross-Sectional Study
Authors: Al-Jabri Basma , Alaifan Meshari , Khan Yousef , Sanad Khalid , Alkhotani Abdullah , Siddiqui Malaz , Zahran Abdullah , Al-Qarni Sultan , Dawood Tareq
Published: January 2025

Objectives:
This study aimed to compare the prevalence, types, and frequency of gastrointestinal (GI) symptoms between children diagnosed with autism and those who are not.
Methods:
In this cross-sectional study, a questionnaire was distributed across various regions of the Kingdom of Saudi Arabia, including children of 2 to 18 years.
Results:
A total of 358 responses including 174 (48.6%) about children diagnosed with autism and 184 (51.3%) about typically developing children. Overall, insignificant differences in GI manifestations were observed between children diagnosed with autism spectrum disorder (ASD) and typically developing children. However, specific GI symptoms, such as constipation (39.7% in ASD vs. 24.5% in controls) and gastroesophageal reflux (9.2% in ASD vs. 2.2% in controls), were more prevalent among children with autism. Conversely, symptoms like abdominal pain (41.8% in controls vs. 18.4% in ASD) and vomiting (14.7% in controls vs. 5.7% in ASD) were more common in typically developing children.
Conclusions:
This study indicated that children with autism in Saudi Arabia were more likely to experience specific GI symptoms compared to typically developing peers. Early screening could enhance treatment outcomes and improve quality of life.
The impact of adverse childhood experiences on migraine incidence and severity: a case-control study in Jeddah, Saudi Arabia
Authors: Alotaibi Alaa , Mal Turky , Alorfi Yara , Alshabani Doaa , Alzeer Latifah , Softah Abdulrahman , Alzubide Abdulaziz , Sultan Abdulsamad , Alghamdi Joud
Published: January 2025

Objective:
This study aimed to investigate the potential correlation between adverse childhood experiences (ACEs) and the onset of migraines.
Methods:
This case-control study included 612 participants from Jeddah, Saudi Arabia. The case group consisted of 311 migraine patients from King Abdulaziz University Hospital, while 301 individuals without migraines formed the control group. Data were collected through structured surveys.
Results:
In the migraine group, 80.1% were women, with the highest prevalence among those aged 30 to 45 years (51.4%, p-value0.05, including experiences such as parental loss or household dysfunction. However, in the migraine group, parental loss was related to more severe headaches; median pain score = 9.0, p-value=0.047. Attacks of migraine significantly affect daily life, social activities, and professional activities, high frequency of drug intake (80.1%), and reduced working and academic efficiency.
Conclusion:
Although ACEs were not related to migraine prevalence, parental loss was associated with higher headache severity. These findings indicated the complexity of migraines and the need to incorporate psychosocial variables in their management. Further research into the genetic, environmental, and psychological influences that cause migraine is required.
The diagnostic accuracy of chest x-rays and chest ultrasonography for diagnosing trauma patient's pneumothorax in the emergency room by emergency medicine physicians
Authors: Alanazi Mazi , Alghamdi Mohammed , Alfaraj Fatimah , Almulhim Sarah , Alharthi Ghadah , Marar Fatima , Ghafail Zahra , Alshehri Abdulrahman , Albaqami Renad , Alshuaibi Munirah
Published: January 2025

This study aimed to evaluate the diagnostic precision of chest radiography (CXR) and ultrasonography (US) by physicians to detect pneumothorax in trauma patients in the ED. The PRISMA guideline was followed to conduct this study. Suspected pneumothorax patients were drawn from prospective and comparative studies. In addition to the US performed by physicians, patients had to get a reference standard test (CT scan of the tube thoracostomy). Systematic research was developed and carried out in the electronic databases Cochrane, MEDLINE, Embase, and Web of Science. The publications published between the years 2012 and 2024 were searched that satisfied the inclusion criteria. Ultrasonography was found to be superior to radiography for the first evaluation of patients with serious thoracic cavity injuries. US is a useful triage method for ruling out pneumothorax in patients with chest trauma. Based on the current results, it is recommended to use US as an adjunct in the Advanced Trauma Life Support (ATLS) method.
Depression in emergency department and increased risk of hospitalization and emergency care utilization
Authors: Alanazi Mazi , Alramadhan Hajar , Alkishi Basel , Alramadhan Yahya , Alanazi Ahmed , Almohammadi Yousef , Almutairi Mohammad , Alali Sarah , Wali Muwaffaq , Alalwani Abeer
Published: January 2025

This study examined emergency department (ED) patients with depressed symptoms to detect depression and the issue of patient access to high-quality therapy. Additionally, the incidence of possible treatment obstacles and depressive symptoms were connected in ED patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to conduct this study. A comprehensive search was conducted of the Cochrane and PubMed databases. To be included in the systematic review, studies must evaluate the information currently available regarding adult depressed patients who visited the emergency room. Limits search results to articles released between the years 2012 and 2024. Recurrent use of ED in individuals with nonspecific pain was associated with moderate to severe depression. Significant rates of depression were seen in adult ED patients who did not have psychiatric issues, and these rates were also significantly associated with an increased likelihood of ED usage and hospitalization. Over half of ED depression visits needed inpatient admission.
The place of investment life insurance in personal finance
Authors: Vlasova Yuliya Ashumovna , Gerzelieva ZHanneta Il'yasovna
Published: January 2025

The paper is devoted to the features of such a product as investment life insurance and the assessment of its role in personal finance. The relevance of the topic is due to the growth of investment activity among the population and, accordingly, interest in various forms of accumulation and saving of funds. A special role in this process is played by state policy aimed at developing financial literacy among the population, which lays down an understanding of the need for independent financial planning by the population. One of the tools that can ensure the safety and increase of funds in the medium and long term is such a specific and not yet popular enough tool in the Russian Federation as investment life insurance. The subject of the study is investment life insurance as a financial instrument in the personal finance system. The object of the study is the features and principles of investment life insurance, its relevance, advantages and risks for customers. The purpose of the article is to identify the main characteristics of investment life insurance, assess its role and place in the structure of personal finance, as well as analyze its advantages and disadvantages for private investors and depositors. As conclusion, the author systematized the ideas about the role of investment life insurance in personal finance and proposed the methods to popularize the product. The life insurance investment market will continue to grow in the coming years. We see an increase in customer interest in combined products, as well as in policies with sustainable investments that provide protection against inflation. Investment life insurance is an effective tool for those who are looking for a balance between protection and capital accumulation. It is suitable both for individual financial planning and for ensuring the future of the family.
Artistic features of silver tombstone complexes for the relics of Russian saints of the 1730s-1750s
Authors: Bykova Iuliia Igorevna
Published: January 2025

The purpose of the study is to identify the artistic features of the silver tombstone complexes over the relics of saints of the 1730s–1750s, created by imperial order. The author of the article set tasks to consider the problems related to their authorship, the stylistic analysis of monuments in the context of jewelry art of the XVIII century, the discovery of prototypes and samples in the European culture of that time. To achieve the stated goal of this study, the author applied a comprehensive method based on a combination of art criticism and historical and cultural approach. The object of study were three tombstones: St. Sergius of Radonezh (1731–1737), St. Alexander Nevsky (1748–1752) and St. Dimitry of Rostov (1758), commissioned by Empresses Anna Ioannovna and Elizabeth Petrovna from silver. Groups of various craftsmen took part in their creation (artists, carvers, sculptors, silversmiths, coiners, etc.). To achieve the designated goal of this study, the author applied a comprehensive method based on a combination of art criticism and historical and cultural approach. When working on the article, not only the results of published scientific research were used, but also a large array of unpublished archival documents. Thanks to the reference to archival materials, the author of the article managed to find the names of many craftsmen (carvers, silversmiths, etc.) who made these works of jewelry, as well as artists (painters and sculptors) who created drawings and sketches of these ensembles. In the article, the author cites the prototypes of some tombstone complexes he found. The analysis of the stylistic features of each tombstone complex allowed the researcher to identify both differences between them and common features that differ from similar complexes that were created both before (the Old Russian period of the XVI–XVII centuries) and after (the second half of the XVIII – XIX centuries).
Moscow triumphal arches for the coronation of Catherine II in the sources of the 1760s. New materials
Authors: Tyukhmeneva Ekaterina Alexandrovna
Published: January 2025

The triumphal arches “for the occasion” as part of the ceremonial culture of Russia of the 18th century have not survived to the present day. Only graphic and written sources allow us to recreate their appearance. This article presents and analyzes new, as well as little-researched archival materials on the construction and existence of the Moscow triumphal arches in 1762, dedicated to the coronation of Catherine II. The work with such materials is based on the methods of source studies, art criticism, historical, cultural and iconographic analysis. The main object of this study were two groups of arch inventories from 1762 and 1766 and the documents accompanying them. Special attention is paid to the project of the triumphal arches program, the study of which helps to assess the level of development of allegorical culture in Russia at that time. The authors of this project and the circle of people who participated in its testing are also identified. The written materials presented and analyzed in the article made it possible to reconstruct in sufficient detail the appearance of the realized triumphal arches of 1762, trace the construction process and the further fate of temporary monuments, and complement the creative biographies of the masters involved in the works. The study clarified the number and location of paintings, emblems, statues and inscriptions, the technique and materials of their execution, the color scheme of festive ensembles, as well as the decoration of the inner surface of the arched spans and the space adjacent to the triumphal arches. Together with graphic sources, the written materials considered in the article significantly enriched the available information about the art of festive decoration of the city, the established mechanism of preparation for official celebrations and the artistic life of Moscow in the 18th century.
Features of Seleucid Temple construction: Architecture in a political context
Authors: Sivkina Nataliya Yurievna , Guseva Anastasiya Sergeevna
Published: January 2025

The article examines the features of temple architecture in the context of the religious policy of the early Seleucids. The study is based on archaeological and epigraphic materials, since the narrative information contains only some references to the policies of the first kings of the Seleucid dynasty. Seleucus I, the successor of Alexander the Great, as well as other diadochi, faced the question of strengthening his power. At the same time, the reign of Seleucus Nicator and his son Antiochus is one of the most stable in the history of the Seleucid empire. This was a consequence of the well-thought-out internal policy of the first kings. The research methods were both the traditional general philosophical methods of analysis and synthesis for this type of work, as well as the method of systematization of materials. The novelty of the work lies in the authors' attempt to consider one of the controversial issues on the implementation of the policy of "merging peoples" through the study of the features of temple architecture. Given the state of the source base, according to the authors, attention should be paid to the material evidence. They allow us to supplement existing knowledge about the internal politics of the first Seleucids. Using the example of architectural monuments, it can be argued that integration in the cultural and religious sphere did not just take place, but was a consequence of the purposeful policy of the early Seleucids. Accordingly, the rapprochement of peoples took place within the framework of a new integration model. The historical paradox lies in the fact that the early Seleucid construct turned out to be close to the prototype of Alexander the Great, which was negatively perceived during the reign of the famous conqueror and rejected after his death by the diadochi.
The social and professional heroism of the ceramic artist. The creative and pedagogical path of Pavel Alexandrovich Pakharukov
Authors: Ivlev Nikita Nikolaevich
Published: January 2025

The purpose of the study is the life and creative path of the Chelyabinsk ceramic artist Pavel Alexandrovich Pakharukov. The creative path of the artist-teacher is considered as a manifestation of professional and social heroism in the difficult socio-economic conditions of life in Russia at the end of the XX-beginning of the XXI century. The object of research is the biography, the path of creative and professional formation and development of Pavel Alexandrovich Pakharukov. The subject of the research is the artistic and pedagogical techniques and methods used by Pavel Alexandrovich Pakharukov, the moral guidelines of the teacher-artist. Heroic images created in the cultural space reflect the values of society and realize the function of transferring these values from generation to generation, contribute to the preservation and formation of traditions. This is especially true for decorative and applied art, which has its roots in traditional folk art and is an important element in the preservation and development of traditional values in the arts. The formed heroic images are a spiritual support both for an individual and for our people, create values and guidelines for the whole society. In the course of the study, historical-systemic, historical-genetic, historical-biographical and diachronic methods were applied. The scientific novelty of the research lies in the introduction into scientific circulation of previously unexplored and unpublished information about Pavel Alexandrovich's creative and professional achievements. The work is based on an interview with the main character of the study, P. A. Pakharukov, in which he gives an interpretation of his key creative and pedagogical achievements. Based on the materials obtained during the research, an attempt has been made to present the main milestones of the life and work of the artist and teacher Pavel Alexandrovich Pakharukov in the most complete and consistent way.