bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Informasi Penjualan Produk Pertanian Pada Badan Usaha Milik Desa (BUMDES) Sinar Bulan
Authors: Muhammad Fajrian Noor  , Nanang Rahman  , Sofyar
Published: February 2024

Technological developments that are increasingly advanced and developing can be utilized to support human work, including in the government sector. One form of good government can be seen from the services provided to the public which have been carried out effectively and efficiently. In the business world, the role of information technology and reliable application programs is no longer in doubt in supporting the ability of business units to win business competition. BUMDes Sinar Bulan Village has several business units that have been developed, one of which is the sale of agricultural products, because almost all of the people of Sinar Bulan Village are farmers, so agricultural products can be used as an opportunity by the village government to increase BUMDes income. In terms of recording buying and selling transactions, it is still done manually and does not comply with the rules in the accounting application program, resulting in an ineffective and inefficient recording system. Therefore, this research aims to create a Sinar Bulan village-owned enterprise (BUMDES) application program for WEB-based sales of agricultural products
Analisis Pengaruh Manajemen Kas Dalam Proses Pengambilan Keputusan
Authors: Sandra Iriawan  , Windy Sharlina Indrianti  , Hikmahwati
Published: February 2024

Penelitian ini bertujuan untuk mengetahui seberapa pengaruh  manajemen kas untuk mengelola perputaran kas dalam perusahaan sehingga mampu menjadi salah satu faktor penting untuk membuat keputusan suatu perusahaan kedepannya. Manajemen kas diketahui sebagai bagian dari pengendalian kas dimana arus kas yang terjadi harus dikelola dengan efektif sesuai dengan tingkat likuiditasnya. Tujuan dari manajemen kas ini sendiri tidak lain adalah untuk mengelola kas yang baik dalam suatu perusahaan yang akan membantu mendanai pengeluaran untuk memenuhi operasi jangka pendek maupun jangka panjang dan memenuhi kewajiban yang harus dipenuhi ketika jatuh tempo. Metode yang dilakukan hanya berdasarkan artikel-artikel atau jurnal-jurnal yang mengulas tentang dampak yang diberikan oleh manajemen kas beserta peranannya sebagai pengendali kas perusahaan. Berdasarkan hasil penelitian yang menitikberatkan literasi diketahui bahwa proses pengambilan keputusan sangat penting untuk kemajuan perusahaan dan kas, sebagai salah satu sumber daya terpenting dalam menggerakkan perusahaan pun perlu dikelola dengan baik sehingga tujuan perusahaan tercapai dengan tepat. Sebuah perusahaan yang tidak mampu mengelola arus kas tersebut akan berdampak pada kehancuran dari segi keuangan yang menyebabkan menurunnya nilai suatu perusahaan. Pengendalian inilah yang harus dikelola oleh seseorang yang kredibel oleh petinggi perusahaan.
Preferensi Masyarakat Dalam Penyaluran Zakat dan Infak Sedekah : Tinjauan Pada Sebagian Masyarakat di Kabupaten Banjar
Authors: Basyirah Ainun  , Mahyuni  , Nifa Silvia
Published: February 2024

Zakat merupakan sejumlah harta yang wajib dikeluarkan oleh seorang muslim atau badan usaha untuk diberikan kepada pihak yang berhak menerimanya sesuai dengan syariat Islam. Kabupaten Banjar dikenal sebagai salah satu kabupaten di Kalimantan Selatan yang masyarakatnya mayoritas muslim dan sangat religius sehingga seharusnya dapat mengoptimalkan potensi pengumpulan zakatnya. Tujuan penelitian ini adalah untuk mengetahui preferensi masyarakat di Kabupaten Banjar yang merupakan muzakki dalam menyalurkan dana zakat apakah melalui organisasi pengelola zakat atau langsung kepada mustahik dan faktor apa saja yang mempengaruhinya. Metode penelitian yang digunakan adalah kualitatif deskriptif dengan menggunakan data primer berupa hasil tanggapan kuisioner yang telah disebarkan kepada responden. Pemilihan sampel menggunakan teknik probability sampling yang memberikan peluang yang sama bagi setiap anggota populasi untuk dipilih menjadi anggota sampel dengan jumlah sampel sebanyak 100 orang yang merupakan muzakki yang ada di Kabupaten Banjar. Kesimpulan yang diperoleh adalah sebagian besar dari sampel penelitian yaitu sebanyak 60% lebih memilih menyalurkan zakat langsung kepada mustahiq karena kurangnya pengetahuan mereka tentang organisasi pengelola zakat, sedangkan 40% dari sampel penelitian memilih menyalurkan zakat melalui organisasi pengelola zakat dengan perincian 30% memilih menyalurkan zakat lewat organisasi pengumpul zakat bentukan pemerintah (BAZNAS) dan 10% memilih menyalurkan zakat lewat organisasi pengelola zakat bentukan masyarakat seperti LAZISMU, Rumah Zakat, Dompet Dhuafa, dan BSI Maslahat. Diketahui beberapa faktor yang mempengaruhi kepercayaan masyarakat terhadap organisasi pengelola zakat diantaranya adanya keterbukaan, pengelolaan yang kompeten, kejujuran, integeritas, akuntabilitas dan penghargaan pada orang lain.
Faktor-faktor yang Mempengaruhi Return Saham di Perusahaan Syariah
Authors: Syafitri Puspa Rosiana , Fadhillah Rizky , Andriani
Published: February 2024

Tujuan dari setiap investor pemaksimalan terhadap return. Namun dalam beberapa dekade terakhir terjadi fluktuasi. Hal ini dipengaruhi oleh beberapa faktor. Faktor yang mempengaruhi return saham yaitu Total Asset Turnover, Return On Asset, Return On Equity, dan Price to Book Value. Penelitian ini bertujuan untuk mengetahui pengaruh Total Asset Turnover, Return On Asset, Return On Equity, dan Price to Book Value terhadap return saham syariah pada perusahaan yang terdaftar dalam kelompok Jakarta Islamic Index. Metode penelitian yang digunakan adalah kuantitatif dan ualitatif dengan pendekatan deskriptif. Populasi dalam penelitian ini adalah seluruh perusahaan syariah yang tercatat dalam Jakarta Islamic Index (JII) selama periode 2017-2021 yakni sebanyak 51 perusahaan dengan sampel sebanyak 16 perusahaan. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan metode pengumpulan data diperoleh bersumber dari laporan tahunan perusahaan-perusahaan yang terkait. Hasil dari pengujian hipotesis dalam penelitian ini secara parsial ditunjukkan bahwa Total Asset Turnover (TATO) tidak mempunyai pengaruh positif dan signifikan terhadap return saham syariah pada perusahaan syariah, Return On Asset (ROA) mempunyai pengaruh positif dan signifikan terhadap return saham syariah, Return On Equity (ROE) tidak mempunyai pengaruh positif dan signifikan terhadap return saham syariah, dan Price to Book Value (PBV) tidak mempunyai pengaruh positif dan signifikan terhadap return saham syariah. Adapun secara simultan Total Asset Turnover (TATO), Return On Asset (ROA), Return On Equity (ROE) dan Price to Book Value (PBV) berpengaruh terhadap return saham syariah
Pendampingan Produktivitas Umkm UD.Widya Handicraft Pasca Pandemi Covid-19 Desa Gintangan, Kec. Blimbingsari, Kab. Banyuwangi
Authors: Agus Salim Helmi , Untari Dewi , Hamliyah Hamliyah
Published: February 2024

Kegiatan pendampingan terhadap UMKM merupakan salah satu bentuk dari tri dharma perguruan tinggi. UD Widya Handicraft yang terletak didesa Gintangan kecamatan Blimbingsari kabupaten banyuwangi merupakan mitra yang mempunyai dinamika yang terkena pengaruh dan terdampak secara ekonomi semenjak awal pandemi covid-19 sampai pendemi hampir berakhir dan sekarang salah satu UMKM yang mencoba bangkit dari pandemi tersebut. UD. Widya Handicraft adalah UMKM di bidang kerajinan tangan yang memproduksi berbagai macam produk untuk kebutuhan pokok dan seni yang berbahan dasar bambu . Berdasarkan data penjualan yang dimiliki UD. Widya Handicraft terjadi penurunan yang signifikan mulai tahun 2019 – 2022. Tahun 2022 merupakan awal kebangkitan iklim usaha di era kemajuan teknologi informasi yang berbasis digital. Era digital mengakibatkan selera konsumen terhadap jenis produk kerajinan mengalami perubahan, UD. Widya Handicraft harus mulai berbenah untuk melihat potensi jenis produk hasil kerajinan dengan model atau selera konsumen pada generasi sekarang. Dengan kolaborasi keunggulan produk dengan selera konsumen sekarang menjadi pemicu UMKM ini untuk menaruh harapan besar dalam menatap pasar baru di era baru.
Pendampingan Praktek Dokter Hewan menuju Rintisan Klinik Dokter Hewan Mandiri
Authors: Sulaksono Hary , Hidayah Tamriatin
Published: February 2024

UKM Satwa Sehat Karimata, di jalan Karimata Jember berdiri sejak tahun 2021. Usaha yang oleh Drh. Agung Triraharja ini mulai berkembang cukup baik. Praktek Dokter hewan telah berlangsung melewati tantangan dan peluang, dan kemauan untuk survive dan berkelanjutan, Program pendampingan praktis menjadi suatu hal yang diperlukan sebagai bentuk  kolaborasi antara praktisi usaha dengan akademisi. Belum terselenggaranya pengelolaan usaha mandiri yang profitable dan bebas riba, serta taat pajak. Pendampingan melalui kolaborasi prktis dg akademisi. Gerai yang ada sebagai lokasi petshop merupakan lahan yang disewa per 2 tahunan meskipun  dapat diperbaharui secara berkala. Manajemen usaha petshop masih memerlukan peningkatan pelayanan dan memperbaiki/membantu fasilitas layanan melalui penyiapan SDM.  Rekrutmen dan seleksi karyawan agar trampil dan jujur, Membangun perilaku disiplin dan ramah, Kompensasi (reward) yang memadai, punishment masih perlu dibenahi lebih lanjut, penataan ulang Lay out/ tata letak, perlu renovasi atau pengadaan Display, dan rak barang dagangan, Stok barang dagangan relative terbatas menyesuaikan dengan trend permintaan dan kebutuhan. Kandang opsional belum cukup proposional, meja dan kursi terbatas.
Peningkatan Pengetahua Kematangan Karir Siswa Smk Yosonegoro Magetan
Authors: Raihana Permata Ashfi , Roesmalita Mita , Mahira Raisa Suri
Published: February 2024

Abstract

This research aims to improve the career maturity of students of SMK Yosonegoro in Magetan Regency, East Java. Career maturity is the readiness of individuals to face the tasks of career development according to their stage of development. However, some students of SMK Yosonegoro face challenges related to career maturity. To overcome this problem, the researchers conducted community service activities that included several stages, namely: interviewing BK and 2 students to obtain initial data on the problems faced by students; giving a career maturity scale consisting of 33 items to 16 grade 12 students as a sample to measure their level of career maturity before and after participating in psychoeducation; providing psychoeducation on career maturity that contains material on career maturity strategies and raising awareness about careers in the future for students; and analysis of post-test data using Excel to find the average and standard deviation to determine the category range of low, medium, and high on the post-test results. From the results of the post-test data analysis, it was found that most students (12 people) had a moderate level of career maturity, only one person had a low level of career maturity, and three people had a high level of career maturity. This shows that the psychoeducation given has a positive impact on increasing students’ career maturity.Thus, it can be concluded that this community service activity successfully helped students of SMK Yosonegoro in improving their career maturity according to their stage of career development. 

 

Keywords: Career Maturity, Psychoeducation, Vocational High School Students
The Effect of Apathy and Depressive Syndromes on Functional Outcomes in Alzheimer’s Disease
Authors: Njomboro Progress , Lekhutlile Tlholego
Published: February 2024

Background: Alzheimer’s disease (AD) is the most common cause of dementia. Its initially characterized by progressive short-term memory loss followed by cross-domain cognitive decline in later stages resulting in significant functional deficits and loss of activities of daily living (ADLs) independence. Apathy and depression are frequent neuropsychiatric sequelae in AD, but their contribution to functional deficits is poorly understood. Objective: We aimed to quantitatively investigate if apathy and depressive symptoms predict ADLs in AD. We also wanted to fractionate apathy dimensions by factor-analyzing the apathy evaluation scale (AES) and then investigate the dimensions’ relation to ADLs. Methods: We recruited a sample of 115 patients with probable or possible AD and assessed them for depression, apathy, and ADLs alongside other measures. We hypothesized that apathy and depressive symptoms would predict ADLs and that AES items will load into cognitive, behavioral, and affective factors that would differentially relate to ADLs. Results: Our results indicated that apathy symptoms predict ADLs deficits. The AES items resolved into a three-factor solution but the manner of clustering diverged from that proposed by AES authors. When these factors were regressed simultaneously, only behavioral apathy predicted global ADLs. Distinguishing basic from instrumental ADLs showed that behavioral and cognitive apathy symptoms associate with ADLs deficits while affective symptoms do not. Conclusions: Our results highlight the influence of apathy on ADLs in AD. This has important implications for patient care considering the high prevalence of apathy in AD and other dementing illnesses.
Music Therapy as a Complementary Treatment in Patients with Dementia Associated to Alzheimer’s Disease: A Systematic Review
Authors: Rossi Eleonora , Marrosu Francesco , Saba Luca
Published: February 2024

Background: Alzheimer’s disease (AD) is a complex condition that affects various aspects of a patient’s life. Music therapy may be considered a beneficial supplementary tool to traditional therapies, that not fully address the range of AD manifestations. Objective: The purpose of this systematic review is to investigate whether music therapy can have a positive impact on AD patients and on which symptoms. Methods: The main research databases employed have been PubMed and Cochrane, using the keywords “dementia”, “music therapy”, “Alzheimer”, “fMRI”, “music”, and “EEG”. Results: After removing duplicates and irrelevant studies, 23 were screened using set criteria, resulting in the final inclusion of 15 studies. The total number of participants included in these studies has been of 1,196 patients. For the fMRI analysis the search resulted in 28 studies on PubMed, two of which were included in the research; the total number of participants was of 124 individuals. The studies conducted with EEG were found using PubMed. The initial search resulted in 15 studies, but after a more accurate evaluation only 2 have been included in the analysis. Conclusions: Even though the data currently available is not sufficient to draw conclusions supported by robust statistical power, the impact of music therapy on AD neuropsychiatric symptoms deserves great interest. Further research should be ushered, possibly multicentric studies, led with neuroimaging and other recent techniques, which can eventually open views on the music role in improving the cognitive status in AD.
Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer’s Disease
Authors: Sabbir Mohammad Golam
Published: February 2024

Background: Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) has been linked to the pathogenesis of Alzheimer’s disease (AD). Our recent study found significantly lower CHRM1 protein levels in AD patient cortices, linked to reduced survival. Furthermore, using knockout mice (Chrm1−/−) we demonstrated that deletion of Chrm1 alters cortical mitochondrial structure and function, directly establishing a connection between its loss and mitochondrial dysfunction in the context of AD. While CHRM1’s role in the brain has been extensively investigated, its impact on peripheral neurons in AD remains a crucial area of research, especially considering reported declines in peripheral nerve conduction among AD patients. Objective: The objective was to characterize Chrm1 localization and mitochondrial deficits in Chrm1−/− dorsal root ganglion (DRG) neurons. Methods: Recombinant proteins tagged with Green or Red Fluorescent Protein (GFP/RFP) were transiently expressed to investigate the localization of Chrm1 and mitochondria, as well as mitochondrial movement in the neurites of cultured primary mouse DRG neurons, using confocal time-lapse live cell imaging. Transmission electron microscopy was performed to examine the ultrastructure of mitochondria in both wild-type and Chrm1−/− DRGs. Results: Fluorescence imaging revealed colocalization and comigration of N-terminal GFP-tagged Chrm1 and mitochondrial localization signal peptide-tagged RFP-labelled mitochondria in the DRGs neurons. A spectrum of mitochondrial structural abnormalities, including disruption and loss of cristae was observed in 87% neurons in Chrm1−/− DRGs. Conclusions: This study suggests that Chrm1 may be localized in the neuronal mitochondria and loss of Chrm1 in peripheral neurons causes sever mitochondrial structural aberrations resembling AD pathology.
Improving Healthcare Quality and Clinical Outcomes for Persons with Dementia in the Sub-Acute Hospital Through Person-Centered Care Practice
Authors: Chenoweth Lynn , Burley Claire , Cook Jacquelene , Cheah Seong-Leang , Reyes Patricia , Maiden Genevieve , McGuire Jane , McCade Donna , Brodaty Henry , Sukhapure Mayouri , Harrison Fleur , Williams Anna
Published: February 2024

Background: Person-centered care is considered beneficial for persons with dementia. Objective: To evaluate the impact of a person-centered knowledge translation intervention on the quality of healthcare and outcomes for persons with dementia. Methods: Over nine months, sub-acute hospital nursing, allied health, and medical staff (n = 90) participated in online and/or face-to-face person-centered education and were supported by senior nursing, allied health, and medical staff champions (n = 8) to implement person-centered healthcare. The quality of healthcare service, ward climate and care delivery were evaluated pre/post study intervention. In the week following hospital admission (Time 1) and week of discharge (Time 3), agitation incidence (co-primary outcome) was assessed in participants with dementia (n = 80). Participant delirium (co-primary outcome), accidents/injuries, psychotropic medicines, length of stay, readmission and discharge destination (secondary outcomes) were compared with a retrospective group (n = 77) matched on demographics, cognition and function in activities of daily living. Results: Improvements occurred post-intervention in service quality by 17.5% (p = 0.369, phi = 0.08), ward climate by 18.1% (p = 0.291, phi = 0.08), and care quality by 50% (p = 0.000, phi = 0.37). Participant agitation did not change from Time 1 to Time 3 (p = 0.223). Relative to the retrospective group, significant reductions occurred in participant delirium (p = 0.000, phi = 0.73), incidents/injuries (p = 0.000, phi = 0.99), psychotropic medicine use (p = 0.030, phi = 0.09), and hospital readmissions within 30 days (p = 0.002, phi = 0.25), but not in discharge to home (p = 0.171). Conclusions: When person-centered healthcare knowledge is translated through staff education and practice support, persons with dementia can experience improved healthcare services and clinical outcomes, while healthcare services can benefit through reductions in unplanned service use.
Fuzzy speech emotion recognition considering semantic awareness
Authors: Xiong Yu , Cai Ting , Zhong Xin , Zhou Song , Cai Linqin
Published: February 2024

Speech emotion recognition is of great significance in the industry such as social robots, health care, and intelligent education. Due to the obscurity of emotional expression in speech, most works on speech emotion recognition (SER) ignore the consistency of speech emotion recognition, leading to fuzzy expression and low accuracy in emotional recognition. In this paper, we propose a semantic aware speech emotion recognition model to alleviate this issue. Specifically, a speech feature extraction module based on CNN and Transformer is designed to extract local and global information from the speech. Moreover, a semantic embedding support module is proposed to use text semantic information as auxiliary information to assist the model in extracting emotional features of speech, and can effectively overcome the problem of low recognition rate caused by emotional ambiguity. In addition, the model uses a key-value pair attention mechanism to fuse the features, which makes the fusion of speech and text features preferable. In experiments on two benchmark corpora IEMOCAP and EMO-DB, the recognition rates of 74.3% and 72.5% were obtained under respectively, which show that the proposed model can significantly improve the accuracy of emotion recognition.
RETRACTED: A hybrid stacking classifier with feature selection for handling imbalanced data
Authors: Abraham Asha , Kayalvizhi R. , Mohideen Habeeb Shaik
Published: February 2024

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Similarity measure between generalized intuitionistic fuzzy sets with three kinds of negation
Authors: Wu Xiaogang
Published: February 2024

The similarity measure of intuitionistic fuzzy sets is a primary method for dealing with uncertainty and fuzzy problems and is commonly used in fuzzy decision-making and pattern recognition. The current mainstream similarity measure is based on the classical fuzzy set with only one negation, which often violates the intuitionistic problem in applications because the actual semantics of multiple negations are not considered. To solve the inconsistency and irrationality problems in the classical similarity methods, we introduce three negations (contradiction negation, opposition negation, and mediation negation) in the intuitionistic fuzzy set to obtain the generalized intuitionistic fuzzy set and prove its related property theorem. On this basis, our similarity measure adopts a mediational negation to represent non-membership, which fully utilizes the multiple negation information of non-membership and hesitancy and avoids the loss of fuzzy information. We verify the method’s rationality, validity, and originality through pattern recognition experiments and numerical examples, which improves the performance of intuitionistic fuzzy set similarity in practical applications and provides a new approach for future research on intuitionistic fuzzy inference.
Transformer-based lithium battery fault diagnosis research for electric vehicles
Authors: Huang Jui-Chan , Shu Ming-Hung , Lin Hsiang-Tsen , Day Jen-Der
Published: February 2024

With the fast advances of new energy vehicles, the EV battery technology needs to be further improved to follow the step. How to effectively diagnose the electric vehicle’s lithium battery fault becomes a hotspot in the academic circle. This study has proposed new method that uses the state of charge of the battery and self-coder depth to detect faults in the lithium battery group of electric vehicles. First, the study investigates the single lithium battery faults. Then, it builds a lithium battery group fault diagnosis model by integrating the battery charge state and denoising converter network. Finally, it uses a dataset and retired battery group to validate the model’s performance. The results show that the proposed model achieves an accuracy of 93.18% and a recall rate of 93.73% in identifying the faults in the lithium batteries of the electric vehicles and its F1 value is as high as 0.95. Moreover, the modeling method has the lowest prediction error, indicating its high accuracy and robustness in diagnosing the faults of battery packs. This study aims to provide an effective solution for the fault diagnosis of lithium battery packs in electric vehicles.
Disease Trajectories in the Revised Hammersmith Scale in a Cohort of Untreated Patients with Spinal Muscular Atrophy types 2 and 3
Authors: Wolfe Amy , Stimpson Georgia , Ramsey Danielle , Coratti Giorgia , Dunaway Young Sally , Mayhew Anna , Pane Marika , Rohwer Annemarie , Muni Lofra Robert , Duong Tina , O’Reilly Emer , Milev Evelin , Civitello Matthew , Sansone Valeria A. , D’Amico Adele , Bertini Enrico , Messina Sonia , Bruno Claudio , Albamonte Emilio , Mazzone Elena , Main Marion , Montes Jacqueline , Glanzman Allan M. , Zolkipli-Cunningham Zarazuela , Pasternak Amy , Marini-Bettolo Chiara , Day John W. , Darras Basil T. , De Vivo Darryl C. , Baranello Giovanni , Scoto Mariacristina , Finkel Richard S. , Mercuri Eugenio , Muntoni Francesco ,   on behalf of the international SMA consortium (iSMAc)
Published: February 2024

Background:

Spinal muscular atrophy (SMA) is a neuromuscular disorder characterised by progressive motor function decline. Motor function is assessed using several functional outcome measures including the Revised Hammersmith Scale (RHS).

Objective:

In this study, we present longitudinal trajectories for the RHS in an international cohort of 149 untreated paediatric SMA 2 and 3 patients (across 531 assessments collected between March 2015 and July 2019).

Methods:

We contextualise these trajectories using both the Hammersmith Functional Motor Scale Expanded (HFMSE) and Revised Upper Limb Module (RULM). At baseline, this cohort included 50% females and 15% of patients had undergone spinal fusion surgery. Patient trajectories were modelled using a natural cubic spline with age, sex, and random effects for each patient.

Results:

RHS and HFMSE scores show similar trends over time in this cohort not receiving disease modifying therapies. The results confirm the strong correlation between the RHS and RULM previously observed in SMA types 2 and 3a. Scoliosis surgery is associated with a reduction of 3 points in the RHS, 4.5 points in the HFMSE for the SMA 2 population, and a reduction of 11.8 points in the RHS, and 13.4 points in the HFMSE for the SMA 3a populations. When comparing the RHS and RULM, there is a lower correlation in the type 3a’s than the type 2 patients. In the SMA 2 population, there is no significant difference between the sexes in either the RHS or HFMSE trajectories. There is no significant difference in the RULM trajectory in the SMA 2 or 3a participants by sex.

Conclusions:

This study demonstrates that the RHS could be used in conjunction with other functional measures such as the RULM to holistically detect SMA disease progression. This will assist with fully understanding changes that occur with treatments, further defining trajectories and therapy outcomes.
Reduced Prevalence of Parkinson’s Disease in Patients Prescribed Calcineurin Inhibitors
Authors: Silva Jacqueline D. , Jupiter Daniel C. , Taglialatela Giulio
Published: February 2024

Background:

Preclinical evidence suggests calcineurin inhibitors (CNIs) combat α-synuclein-induced neuronal dysfunction and motor impairments. However, whether CNIs prevent or treat Parkinson’s disease (PD) in humans has never been investigated.

Objective:

We seek to ascertain if prescription of CNIs is linked to a decreased prevalence of PD in a varied patient population and to glimpse into the mechanism(s) and target site through which CNIs might decrease PD prevalence.

Methods:

We analyzed electronic health records (EHRs) from patients prescribed the brain penetrant CNI tacrolimus (TAC), the peripherally restricted CNI cyclosporine (CySp), or the non-CNI sirolimus (SIR). For comparison, EHRs from a diverse population from the same network served as a general population-like control. After propensity-score matching, prevalence, odds, and hazards of PD diagnoses among these cohorts were compared.

Results:

Patients prescribed CNIs have decreased odds of PD diagnosis compared to the general population-like control, while patients prescribed SIR do not. Notably, patients prescribed TAC have a decreased prevalence of PD compared to patients prescribed SIR or CySp.

Conclusions:

Our results suggest CNIs, especially those acting within the brain, may prevent PD. The reduced prevalence of PD in patients prescribed TAC, compared to patients prescribed SIR, suggests that mechanisms of calcineurin inhibition— other than immunosuppression, which is common to both drugs— are driving the reduction. Therefore, CNIs may provide a promising therapeutic approach for PD.
Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease?
Authors: Koukoulis Tiana F. , Beauchamp Leah C. , Kaparakis-Liaskos Maria , McQuade Rachel M. , Purnianto Adityas , Finkelstein David I. , Barnham Kevin J. , Vella Laura J.
Published: February 2024

Parkinson’s disease (PD) is an increasingly common neurodegenerative disease. It has been suggested that the etiology of idiopathic PD is complex and multifactorial involving environmental contributions, such as viral or bacterial infections and microbial dysbiosis, in genetically predisposed individuals. With advances in our understanding of the gut-brain axis, there is increasing evidence that the intestinal microbiota and the mammalian immune system functionally interact. Recent findings suggest that a shift in the gut microbiome to a pro-inflammatory phenotype may play a role in PD onset and progression. While there are links between gut bacteria, inflammation, and PD, the bacterial products involved and how they traverse the gut lumen and distribute systemically to trigger inflammation are ill-defined. Mechanisms emerging in other research fields point to a role for small, inherently stable vesicles released by Gram-negative bacteria, called outer membrane vesicles in disease pathogenesis. These vesicles facilitate communication between bacteria and the host and can shuttle bacterial toxins and virulence factors around the body to elicit an immune response in local and distant organs. In this perspective article, we hypothesize a role for bacterial outer membrane vesicles in PD pathogenesis. We present evidence suggesting that these outer membrane vesicles specifically from Gram-negative bacteria could potentially contribute to PD by traversing the gut lumen to trigger local, systemic, and neuroinflammation. This perspective aims to facilitate a discussion on outer membrane vesicles in PD and encourage research in the area, with the goal of developing strategies for the prevention and treatment of the disease.
Sine tangent search algorithm enabled LeNet for cotton crop classification using satellite image
Authors: Bhamare Devyani Jadhav , Pudi Ramesh , Krishna Garigipati Rama
Published: February 2024

Economic growth of country largely depends on crop production quantity and quality. Among various crops, cotton is one of the major crops in India, where 23 percent of cotton gets exported to various other countries. To classify these cotton crops, farmers consume much time, and this remains inaccurate most probably. Hence, to eradicate this issue, cotton crops are classified using deep learning model, named LeNet in this research paper. Novelty of this paper lies in utilization of hybrid optimization algorithm, named proposed sine tangent search algorithm for training LeNet. Initially, hyperspectral image is pre-processed by anisotropic diffusion, and then allowed for further processing. Also, SegNet is deep learning model that is used for segmenting pre-processed image. For perfect and clear details of pre-processed image, feature extraction is carried out, wherein vegetation index and spectral spatial features of image are found accurately. Finally, cotton crop is classified from segmented image and features extracted, using LeNet that is trained by sine tangent search algorithm. Here, sine tangent search algorithm is formed by hybridization of sine cosine algorithm and tangent search algorithm. Then, performance of sine tangent search algorithm enabled LeNet is assessed with evaluation metrics along with Receiver Operating Characteristic (ROC) curve. These metrics showed that sine tangent search algorithm enabled LeNet is highly effective for cotton crop classification with superior values of accuracy of 91.7%, true negative rate of 92%, and true positive rate of 92%.
EROI development and validation of a framework to assess the return on the environment of RFID deployment
Authors: Aliakbarian Bahar , Ghirlandi Stefano , Rizzi Antonio , Stefanini Roberta , Vignali Giuseppe
Published: February 2024

This study is grounded in the growing significance of environmental sustainability and the widespread adoption of RFID technology across various industries and is aimed to explore the influence of RFID implementation in supply chains by developing a tool that calculates the net balance of CO2 annual emissions. The tool, known as “Return on the Environment” (EROI), is based on a widely accepted environmental assessment method and it calculates the Global Warming Potential (GWP100) incurred and avoided at various stages in the supply chain strictly related to RFID technology introduction. To validate the tool, two RFID deployments have been assessed: one involving a pharmaceutical product tagged on its secondary packaging to monitor the flow of products through the distribution channel, and another a medical device tagged on both primary and secondary packaging to oversee product flow from the supplier distribution center to the hospital operating theatres. In both cases, the results indicate that implementing RFID technology reduced GWP100 compared to the scenarios without RFID. This was primarily due to decreased product shrinkage, lower missing or expired products, and reduced additional transportation due to shipping errors. The tool is versatile and it could be applied to any type of product, serving as a source of inspiration for those who want to assess the sustainability of RFID technology not only from an economic perspective, i.e. ROI calculation, but also from an environmental view. Future work will address the third level of sustainability, RFID social sustainability, that is the impact RFID deployments may have on empowering people, improving staff and employees working conditions, and creating possibilities for high-value job opportunities.
The effect of pre- and post COVID-19 hazard and risk management of nurses on performance evaluation
Authors: Bingöl Ümran , Kutlu Adalet
Published: February 2024

BACKGROUND: It is important to identify the hazards encountered by nurses before and after COVID-19, assess the potential risks and risk levels, take measures for the identified hazards and risks, and determine the effect of risk management on employee performance evaluation. OBJECTIVE: The aim of this study was to determine the effect of hazard and risk management of nurses before and after COVID-19 on performance evaluation. METHODS: The study consisted of two stages. The first stage had a descriptive design, while the second stage had a one-group pre-test and post-test design. The second stage of the study was conducted during the COVID-19 pandemic. There were 377 nurses who agreed to participate in the study in the first stage and 201 nurses in the second stage. The study data was collected via Information Form, Hazard and Risk Identification Form, and Employee Performance Scale (EPS). In the second stage of the study, training was provided using instruction cards called “Means of Protection Against Hazards and Risks” for potential moderate- and high-level hazards and risks existing after the pre-test. The post-test stage was conducted two weeks after the training. Mann-Whitney U Test, Kruskal-Wallis Test, and Spearman’s correlation coefficients were used for statistical analyses of descriptive statistics. RESULTS: The mean EPS score was found to be pre training 3,85±0,60, after training was found to be 3.92±0.55. Moreover, there was a weak negative correlation between pre- and post-training risk levels during the COVID-19 pandemic. CONCLUSION: Hazard and risk management training had a positive effect on the performance of employees.
Productivity of spring wheat varieties against the background of different methods of basic tillage in arid conditions
Authors: Panfilov Aleksandr , Abdrashitov Rinat Rimovich
Published: February 2024

Abstract. The article provides data on the reserves of productive moisture, the content of nitrate nitrogen, and the yield of spring wheat varieties when grown under different backgrounds of basic tillage. The purpose of the research is to study the response of spring soft and durum wheat varieties to the methods of basic tillage. Methods. The object of research is 3 varieties of spring soft wheat and 2 varieties of spring durum wheat. The experiments were carried out in the central zone of the Orenburg region. For 5 years, two options for basic soil cultivation were studied: plowing to a depth of 23–25 cm and moldless loosening to a depth of 25–27 cm. Scientific novelty. The reaction of spring wheat varieties to the methods of basic tillage, taking into account the reserves of productive moisture and the content of nitrate nitrogen in the soil, in the arid conditions of the Orenburg Cis-Urals was revealed. Results. The reserves of productive moisture during the sprouting phase of spring wheat in a meter layer of soil were satisfactory (less than 130 mm) for four years out of five years of research, and good for one year (150-153 mm). The advantage of non-moldboard tillage was noted in all years of research with the exception of 2019, when the mouldboard background contained 18 mm more soil moisture. Depending on weather conditions, the amount of nitrate nitrogen in the soil varied from very low values in 2022 to high and very high values in 2017 and 2019–2020. The yield of spring wheat, on average according to experience, was 0.6 c per 1 ha higher against the background of moldless loosening. The varietal response to basic soil tillage methods has been established. The Uchitel’ variety did not respond to processing techniques. For other varieties, the difference in favor of non-moldboard tillage ranged from 0.4 centners per 1 hectare for the Tulaykovskaya zolotistaya variety, to 0.7–0.8 centners per 1 hectare for the varieties Ul’yanovskaya 105, Orenburgskaya 10, Bezenchukskaya 210.
Selection and optimization of DNA extraction methods from the leaves of Gleditsia triacanthos L.
Authors: Ryabuha Anna Fedorovna , Kuz'min Petr
Published: February 2024

Abstract. Currently, molecular genetic methods using DNA markers are increasingly used in studies of polymorphism of various populations of woody and shrubby plants. The purpose of this work was the evaluation and selection of protocols for the isolation and purification of DNA from the leaves of Gleditsia triacanthos L. for further studies using DNA labeling. Methods. Four protocols were used to isolate DNA from the leaf blade of Gleditsia triacanthos L. Anionic detergent sodium dodecyl sulfate was used in three isolation protocols for cell lysis, potassium acetate was used for purification from polysaccharides and proteins. In the fourth protocol, a cationic surfactant cetyltrimethyl ammonium bromide was used for cell lysis, the extract was purified with a mixture of chloroform-isoamyl alcohol (24 : 1). Precipitation of the isolated DNA was carried out with isopropanol. The quality of the isolated DNA was evaluated by spectrophotometry, horizontal electrophoresis and Real-time PCR with two types of primers. Results. Optimal conditions for DNA extraction from samples of Gleditsia triacanthos L. containing a large number of metabolites affecting the quality of the isolated extract were selected. By electrophoresis, it was found that both the isolation protocol with sodium dodecyl sulfate and the isolation protocol with cetyltrimethyl ammonium bromide make it possible to obtain a sufficient amount of DNA. The most purified DNA was obtained by the third protocol using sodium dodecyl sulfate and dithiotreitol and by the fourth protocol using cetyltrimethylammonium bromide. The results of PCR of the obtained samples with ITS and psbI-psbK primers indicate that a sufficient amount of product has been obtained and the reproducibility of ISSR markers. The scientific novelty of the work consists in choosing the optimal method of DNA extraction from the leaves of Gleditsia triacanthos L., which is a complex object containing a large number of potential PCR inhibitors. The protocol with sodium dodecyl sulfate and dithiotreitol made it possible to obtain DNA in the right amount and of acceptable quality.
Sanktionierung im Schweizer Unternehmensstrafrecht
Authors:   University of Bern, Wenk Jan Daniel
Published: February 2024

Seit 2003 können Unternehmen in der Schweiz Beschuldigte im Rahmen eines Strafverfahrens sein sowie strafrechtlich sanktioniert werden. Solche Strafverfahren finden immer wieder öffentliche Beachtung, stossen mitunter jedoch auf Kritik. Da namentlich das Sanktionsinstrumentarium gegenüber Unternehmen seit seiner Einführung keinerlei nennenswerte Änderungen erfahren hat, wird im Rahmen dieser Arbeit der Frage nachgegangen, welche Zwecke die Sanktionierung von Unternehmen verfolgt und inwiefern das aktuelle Unternehmensstrafrecht diesen Zwecken gerecht wird. Im Kontext der Sanktionierung spielen die Möglichkeiten der Verfahrenserledigung eine wesentliche Rolle. Daher werden auch diese auf den Prüfstand gestellt und Defizite identifiziert.
PENANAMAN NILAI-NILAI MODERASI BERAGAMA PADA SISWA MADRASAH ALIYAH BILINGUAL KOTA BATU
Authors: Ruma Mubarak  , Nurul Lail Rosyidatul Mu'ammaroh Nurul , A. Zaki Mubaraq
Published: February 2024

Indonesia merupakan sebuah negara yang majemuk, dimana Indonesia memiliki beragam suku, ras, budaya, bahasa, dan agama. Akibat keberagaman ini seringkali timbul konflik di negara Indonesia, salah satunya adalah konfilik beragama. Untuk menghindari konflik tersebut dan adanya perpecahan perlu adanya satu paham. Paham tersebut adalah paham moderasi beragama yang tengah digaungkan oleh Kementerian Agama Republik Indonesia. Pendekatan yang digunakan adalah kualitatif dengan jenis studi kasus. Hasil penelitian menunjukkan bahwa, (1) peran guru pendidikan agama Islam dalam menanamkan nilai-nilai moderasi beragama pada siswa Madrasah Aliyah Bilingual di Kota Batu sangat signifikan; (2) Faktor-faktor yang mempengaruhi keberhasilan guru PAI dalam menanamkan nilai moderasi beragama meliputi pemahaman dan kompetensi guru, dukungan dan kerjasama dengan pihak sekolah, partisipasi aktif siswa, serta pengaruh lingkungan sosial dan keluarga; (3) Strategi dan metode yang efektif dalam menanamkan nilai moderasi beragama pada siswa MA Bilingual Kota Batu meliputi pendekatan dialogis, pemanfaatan sumber daya yang relevan, pembelajaran berbasis pengalaman, penggunaan teknologi informasi, serta penerapan model peran guru sebagai contoh teladan yang mempraktikkan nilai-nilai moderasi beragama dalam kehidupan sehari-hari.
Kelayakan Usaha Gula Kelapa Di Kabupaten Kulonprogo
Authors: Anisya Ayu Putri Merry , Wibowo Teguh Nova Eko
Published: February 2024

The coconut plant (Cocos nucifera L.) is a strategic commodity that has an important role in the social, cultural and economic aspects of society. Kulon Progo Regency has a coconut plantation area of ​​16,104 ha, with productivity reaching 26,152 tons. Meanwhile, Panjatan District contributed 3,856 tons of coconut production with a coconut plantation area of ​​2,065 ha (BPS Kulon Progo Regency, 2021). The large area and high productivity of coconut in Panjantan District have great potential in developing the coconut sugar agro-industry. Apart from that, coconut sugar business actors in Kulon Progo Regency have received the European standard CSQA (Certified Software Quality Analyst) geographical indication certificate from the Ministry of Law and Human Rights. Coconut sugar has an important role in meeting local sugar needs, especially for people who still rely on natural sugar as a source of sugar. Coconut sugar also has high economic value, is in demand in local and international markets. So, this research wants to see the feasibility of the brown sugar business in Panjatan. The location determination technique was carried out purposively, while sampling was carried out using simple random sampling. Data was collected for one week. The results of the analysis show that the feasibility of the coconut sugar business in Panjatan is worth pursuing, because the results of the R/C value analysis are more than 1, namely 1.02. Capital productivity of 1.93% is greater than the bank savings interest rate of 0.175%. Labor productivity of Rp. 112,729,- exceeds the daily wage in Luweng Lor Village, namely Rp. 40,000,-. The BEP price is Rp. 13,106,- which is smaller than the average price for the coconut sugar household industry in Luweng Lor Village, which is Rp. 13,313,-. Meanwhile, the production BEP of 42 kg is smaller than the average production amount for coconut sugar craftsmen, namely 43 kg. To increase the coconut sugar business by using a larger tool for boiling sap, so that productivity will increase.
Pengaruh Corporate Governance Terhadap Pengungkapan Laporan Keberlanjutan dengan Moderasi Peran Audit Internal
Authors: Grediani Evi , Kapti Ani Sri Murwani Kumoro
Published: February 2024

Penelitian ini bertujuan menyelidiki pengaruh corporate governance terhadap pengungkapan laporan keberlanjutan dengan moderasi audit internal. Teknik pemilihan sampel adalah purposive sampling diperoleh 38 perusahaan consumer cyclicals terdaftar di Bursa Efek Indonesia periode tahun 2018-2023 yang membuat laporan berkelanjutan dengan lengkap sehingga total ada 190 pengamatan.. Menggunakan regresi linier berganda untuk menguji hipotesis. Corporate governance diproksikan dengan variabel proporsi jumlah dewan komisaris independen, ukuran dewan komisaris, komite audit. Hasil penelitian menemukan bahwa proporsi jumlah dewan komisaris independen berpengaruh positif terhadap pengungkapan laporan berkelanjutan. Hasil lainnya menemukan ukuran dewan komisaris berpengaruh positif terhadao pengungkapan laporan berkelanjutan. Hasil berikutnya menemukan bahwa variabel seluruh anggota komte berpengaruh positif terhadap pengungkapan laporan berkelanjutan. Namun demikian variabel moderasi peran audit internal tidak secara signifikan memperkuat hubungan corporate governance terhadap pengungkapan laporan berkelanjutan.
The Intervention of Isometric Exercise and Yoga Breathing on Hypertension
Authors: Muhammad Farriz Satriatama  , Agianto
Published: February 2024

Hypertension is the most common disease suffered by Sungai Rangas Ulu Village people. The majority of people who are living in the village are fishermen. The fish obtained are preserved in salted fish and consumed by them. The patient in this case report is a smoker and one of the residents who often consume salted fish. Local culture is one of the factors that cause hypertension. One of hypertension management is complementary therapy such as isometric exercise and yoga breathing. This study described the results of nursing care on hypertension patients through isometric exercise interventions and yoga breathing. This study used a case study method on one of the hypertension sufferers. A client in Sungai Rangas Ulu Village was chosen randomly or accidentally for the case report. A client was given isometric exercise and yoga breathing intervention and observed their blood pressure using a sphygmomanometer every day for six days. The assessment results on the client can establish a nursing diagnosis: risk of the ineffectiveness of peripheral tissue perfusion associated with hypertension. The client was given an isometric exercise and yoga breathing intervention to achieve the outcome. The intervention result was decreased blood pressure (before = 180/120 mmHg, and after = 153/100 mmHg). Isometric exercise and yoga breathing can make the client more relaxed and increase blood circulation, decreasing blood pressure. There is an effect when given isometric exercise intervention and yoga breathing on reducing blood pressure in a client with hypertension.