bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of 220 ml cup supplier selection with AHP method and rating scale: case study PT. sabina tirta utama
Authors: Lumenta Karine Nathania , Wahyuda Wahyuda , Gunawan Suwardi
Published: May 2024

PT. Sabina Tirta Utama is a company that produces Bottled Drinking Water (AMDK) in 220 ml cup packaging. The company has problems related to 220 ml cup suppliers such as found in cup packaging with holes when the goods arrive, the quantity does not match the demand so the company needs suppliers who match the company's criteria and produce good quality packaging through supplier selection and assisted with the selection method. decision. The method used in supplier selection is AHP and rating scale. The AHP method is used to obtain global weight values which are then used to assist in ranking with the rating scale method. The purpose of this study was to determine the criteria and sub-criteria for a 220 ml cup and to identify priority suppliers. Supplier selection using 5 criteria and 11 sub-criteria. AHP weighting results on quality criteria is 0.197, price with a weight result of 0.296 delivery with a weight result of 0.401, communication system with a weight result of 0.035, and packaging capability of 0.07. The results of supplier ranking with a rating scale obtained the priority of the first supplier with a final assessment result of 3.551, namely supplier A with a high-performance category. Meanwhile, another alternative priority is supplier B with a final result of 2.641 in the performance category according to standards.
Pola Komunikasi Dalam Proses Interaksi Sosial Di Dewan Pimpinan Pusat Perkumpulan Penyandang Disabilitas Indonesia
Authors: Sakaril Gufroni , Yoedtadi Moehammad Gafar
Published: May 2024

Abstrak Proses komunikasi dalam organisasi tidak jarang terjadi konflik. Bahkan  konflik itu terjadi  antar anggota pengurus organisasi. Tujuan penelitian ini untuk mengetahui Pola Komunikasi Organisasi  Dalam Proses Interaksi Sosial di Dewan Pengurus Pusat Perkumpulan Penyandang Disabilitas Indonesia. PPDI menggunakan pola komunikasi dengan pola bintang dan pola rantai. Pola bintang digunakan untuk berkomunikasi secara umum, dimana ketua bebas berkomunikasi kepada anggota dan anggota bebas berkomunikasi kepada ketua tanpa perantara orang lain Untuk komunikasi rantai digunakan untuk memberikan informasi yang bersifat pengumuman dari satu bagian kepada seluruh anggota pengurus yang harus melalui Sekretaris Jenderal Proses komunikasi kelompok berlangsung baik karena ketua dapat menerima masukan dari anggoya pengurus demi tercapainya tujuan organisasi Sedangkan proses interaksi sosial yang berlangsung di PPDI  proses assosiatif dan proses dissosiatif. Proses assosiatif meliputi kerja sama, akomodasi dan asimilasi  Didalam mereka melakukan kegiatan proses assosiatif, mereka mampu bergotong royong, rukun, kompak di dalam melakukan kegiatan organisasi.   Proses dissosiatif meliputi persaingan dan konflik. . Proses ini hanya bersifat sebentar dan tidak lama dalam prosesnya karena segera dapat diselesaikan dengan baik.Kata Kunci :   :  Pola Komunikasi, Organisasi,  Interaksi Sosial, Perkumpulan,  Disabilitas
Pengelolaan Media Sosial Instagram Pusat Pelatihan Kerja Daerah Sebagai Alat Informasi Publik
Authors: Amaliyah Putri Riski , Kussanti Devy Putri
Published: May 2024

Abstrak. Instagram @ppkd.jakartatimur yang membahas tentang strategi untuk mengelola media sosial Instagram. Tujuan dari penelitian ini untuk mengetahui bagaimana Instagram @ppkd.jakartatimur dalam menyebarkan informasi publik kepada masyarakat yang dikelola oleh Humas Pusat Pelatihan Kerja Daerah (PPKD) Jakarta Timur tersebut. Peneliti menggunakan metode deskriptif kualitatif. Sedangkan metode pengumpulan data yang digunakan yaitu observasi, wawancara, dokumentasi dan kepustakaan. Teori penelitian ini adalah Humas, Strategi Humas, dan Media Sosial. Teori Humas dalam penelitian ini berkaitan dengan tujuan dan fungsi Humas. Sedangkan Teori Strategi Humas yang digunakan adalah teori Strategi Publikasi, Strategi Persuasi, Strategi Argumentasi, dan Strategi Pencitraan. Teori media sosial yang digunakan berkaitan dengan fitur-fitur yang tersedia di Instagram dan aktivitas yang bisa dimanfaatkan di Instagram. Penelitian ini menemukan bahwa strategi media sosial Instagram @ppkd.jakartatimur yang digunakan oleh Humas Pusat Pelatihan Kerja Daerah (PPKD) Jakarta Timur adalah menyebarkan informasi terkait kegiatan pelatihan yang diimplementasikan ke dalam 4 (empat) strategi yaitu Strategi Publikasi, Strategi Persuasi, Strategi Argumentasi, dan Strategi Pencitraan yang kemudian dituangkan ke dalam unggahan foto atau video di Instagram @ppkd.jakartatimur dengan menggunakan fitur-fitur di Instagram. Kata kunci: Humas, Strategi Humas, Media Sosial dan Instagram
MANIPULASI IDENTITAS DIRI DI MEDIA SOSIAL (Analisis Isi Kualitatif Pada Film “The Tinder Swindler”)
Authors: Vianty Marda , Umarella Farid Hamid
Published: May 2024

Social media exists as a means to communicate with other people. Socializing, working, dating, and sharing life stories on social media are daily activities carried out by people from all over the world. As a result of freedom of communication, various crimes arise on social media.This research focuses on the elaboration of the act of identity manipulation, which describes the acts of self-identity manipulation on social media contained in the documentary film “The Tinder Swindler” so that it can be seen how this phenomenon occurs in real life.The research method used is a qualitative research method with a content analysis approach which aims to analyze the manipulation actions used, so that it can be known how fraud perpetrators manipulate other people.The results obtained from this study are 45 scenes that are in accordance with the categorization in the analysis. Identity manipulation was found related to name, job, appearance, social environment, and photos & videos on social media. With the elaboration of self-identity manipulation in this research, it is hoped that the public will be more aware of other people they meet on social media in order to avoid similar scams, as happened in The Tinder Swindler film.
ANALISIS FRAMING KONTEN YOUTUBE PODCAST CLOSE THE DOOR TERKAIT FILM DOKUMENTER NETFLIX “ICE COLD: MURDER, COFFEE AND JESSICA WONGSO”
Authors: Adi Kun Muhammad
Published: May 2024

Penelitian ini bertujuan untuk mengidentifikasi pembingkaian informasi oleh channel Youtube Podcast Close The Door yang mengangkat isu dari film dokumenter Netflix berjudul “Ice Cold: Murder, Coffee And Jessica Wongso”. Penelitian ini merupakan penelitian kualitatif dengan pendekatan analisis framing model Robert N. Entman. Peneliti menganalisis dua video Youtube yaitu video pertama yang menghadirkan Otto Hasibuan dan video kedua yang menghadirkan Edward Omar Sharif Hiariej. Hasil yang didapat setelah peneliti mengamati dua video tersebut pertama adalah pemilihan narasumber dalam kedua video tersebut menunjukan sisi keberpihakan setiap narasumber sehingga memberikan informasi dari sudut pandang yang kontradiktif. Kedua, munculnya film dokumenter tersebut kembali menyita perhatian publik dengan adanya fakta-fakta baru yang diungkap oleh kedua narasumber. Ketiga, peneliti melihat bahwa sikap Jessica Wongso yang tenang tetap harus menjalani aturan hukum yang berlaku berdasarkan sejumlah kategori barang bukti yang didapatkan. Keempat, kedua video tersebut menunjukan kemungkinan Peninjauan Kembali (PK) kasus Jessica Wongso tetap berpeluang untuk dilakukan meskipun setiap proses penyelidikan hingga pengadilan telah melalui proses yang panjang dan dilakukan secara profesional dan berimbang.
ETIKA NETIZEN INDONESIA DALAM PERKEMBANGAN TEKNOLOGI KOMUNIKASI
Authors: Kristiana Bunga , Rohimah Neli Anggraeni , Yasinta Pasha , Rahmawati Shisi , Agustin Silfiana
Published: May 2024

ABSTRACT: Advances in information technology make society experience a shift or change in lifestyle, including culture, ethics and norms. The fact that Indonesia is a friendly country that upholds norms/values seems to be fading with the development of this technology. The purpose of this research is to find out the attitude of the Indonesian people (netizens) in using social media. This research uses a library study method with a qualitative approach. Data collection techniques use various journals and online articles. This research shows that Indonesian netizens in social media still ignore the norms/values that exist in society. In conclusion, many Indonesian netizens use social media for negative things.Keywords: modernization, social media, ethics.ABSTRAK: Kemajuan teknologi informasi membuat masyarakat mengalami pergeseran atau perubahan gaya hidup baik budaya, etika, dan norma. Fakta Indonesia sebagai Negara yang ramah, menjunjung norma/nilai seakan luntur dengan perkembangan teknologi ini. Tujuan penelitian ini adalah untuk mengetahui bagaimana sikap masyarakat (netizen) Indonesia dalam bersosial media. Penelitian ini menggunakan metode studi perpustakaan dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan berbagai jurnal dan artikel online. Penelitian ini menunjukan bahwa netizen Indonesia dalam bersosial media masih mengabaikan norma-norma/nilai-nilai yang ada di masyarakat. Kesimpulannya, banyak netizen Indonesia yang menggunakan sosial media untuk hal-hal negatif.Kata Kunci: modernisasi, sosial media, etika.
Comparative Study of DGA for Transformer Service Life
Authors: Mohamed Siti Hajar , Abu Bakar Ab. Halim , Syukri Ali Mohd
Published: May 2024

This paper investigates the accuracy and reliability of each DGA method via dissolved gases. Key Gas Method, Doernenburg Ratio Method, Rogers Ratio Method, IEC Ratio Method, and Duval Triangle Method are used to test the 100 sample units. The results obtained are Doernenburg and IEC 94% accuracy each, Duval Triangle 80% accuracy, Rogers 79% accuracy, and Key Gas 75% accuracy. The said individual ratio methods are combined to proceed with newly developed hybrid testing methods that could probably improve the existing DGA methods. The first hybrid method is a combination between Doernenburg and Rogers which produced a slight improvement of 86% accuracy. Then a combination between Doernenburg and IEC delivered a stable prediction result of 94%. It seems that Doernenburg and IEC are the most accurate DGA methods. Although both methods are combined, they still produced a constant accuracy result. While the other methods, such as Key Gas, Rogers, and Duval Triangle, do not achieve satisfactory results.
Effect of Magnesium Oxide Nanoparticle as Additive with Diesel Karanja Biodiesel Blend on Performance of Diesel Engine
Authors: Ahmed Abu Saleh , Gopalan Kalaiyarasu , Binti Ali Dayang Siti Hazimmah , Bin Osman Mohammad Shahril
Published: May 2024

The research study was conducted to produce biodiesel from Karanja oil (Pongamia pinnata) to evaluate the performance and compare the efficiency of samples involving conventional diesel, B10(10% biodiesel and 90% conventional diesel), B10MgO5(10% biodiesel, 85% conventional diesel and 5% Magnesium Oxide), and B10MgO10(10% biodiesel, 80% conventional diesel and 10% Magnesium Oxide), tested with the diesel engine. The production process undergoes a two-step transesterification process since the free fatty acid (FFA) percentage is more than 4%. The titration process reduces the FFA by using Ethanol and Potassium Hydroxide (KOH). Apart from that, the pre-treatment of oil for acid and base transesterification use methanol as a reactant with the presence of Sulfuric Acid and Sodium Hydroxide ((NaOH) as a catalyst. Moreover, Karanja Biodiesel undergoes three characterization tests: Bomb Calorimeter Test, Fourier Transform Infrared Spectroscopy (FT-IR), and Diesel Engine Performance Testing. From the Bomb Calorimeter test, the highest calorific value was recorded by conventional diesel with 45.5815 MJ/kg, followed by B10MgO10 and B10MgO5. While the smallest value was obtained by B10 with 38.7741 MJ/kg. The inclusion of MgO as an additive increases the calorific value for biodiesel. Throughout FT-IR analysis, four fuel samples were evaluated from the wavelength range from 600 to 4000 . The oxidation process that happens due to the presence of magnesium oxide introduces a new bond at the B10MgO5 and B10MgO10 that is the O-H bond. Meanwhile, the performance of the diesel engine is analyzed at the speed of 1400 rpm until 2200 rpm with an interval of 200 rpm. Conventional diesel has a higher brake horsepower (BHP) value at the speed of 2200 rpm. While Karanja biodiesel with 10% Magnesium Oxide as additives has a greater BHP value among other samples from the speed of 1400 to 1600 rpm. Next, the addition of MgO reduces fuel consumption in the blended Karanja biodiesel samples.
Impact of temperature and reaction time on the conversion of polystyrene waste to pyrolytic oil and its diesel engine performance, emission, and lubricity characteristics
Authors: Nizam Awang Muhamad Sharul , Mohd Zulkifli Nurin Wahidah , Mujtaba Abbas Muhammad , Amzar Zulkifli1 Syahir , Mohd Yusoff Mohd Nur Ashraf , Hazwan Ahmad Muhammad , Ashri Wan Daud Wan Mohd , Kalam Md Abul
Published: May 2024

The focus of this research is to see how temperature and reaction time affect the yield and quality of liquid oil obtained by pyrolysis. In a small batch pyrolysis reactor, polystyrene waste was employed as a feedstock. This study also studied the performance and emission characteristics of liquid oil produced at optimal condition (PS100), and its tribological characteristics in diesel engine. The ideal temperature and reaction time were discovered to be 400 °C and 30 min, where the liquid oil yield was 92.94% by mass. PS100 had similar properties to commercial diesel. PS100 comprises 34.6% aromatics, 25.2% alkanes, and 4.3% alkenes. PS100 delivered superior performance than B10 diesel. The brake thermal efficiency, brake power, and brake torque were up by 15.5, 5.6, and 2.38%, respectively, while the brake-specific fuel consumption was down by 8.00%. PS100 emitted 97.06 and 17.3% more hydrocarbon and carbon dioxide than B10, respectively. Its poor exhaust gas emissions have proven a key stumbling block in its application in diesel engine. PS100 demonstrated 27.6% increase in coefficient of friction and 29.8% increase in lubricant contamination as compared to B10. Despite its low lubricity and emissions, PS100 has a lot of potential as a diesel engine alternative fuel.
Predicting Potential Challenges of Regional Hydrogen Cooperation Through a Case Study of the European Union
Authors: Lee Jun Kun , Dhar Ms.
Published: May 2024

Climate disasters will become more common if carbon emissions continue unabated. In response, the United Nations (UN) has called for countries to achieve net-zero carbon emissions by 2050. For many countries, adopting hydrogen energy through imports and regional cooperation is critical to achieving this goal. This study will look at the potential benefits and challenges of regional hydrogen cooperation through a case study of regional hydrogen cooperation in the European Union (EU). The main argument is that the challenges confronting the EU are likely to be encountered elsewhere. The EU provides a particularly favourable environment for regional cooperation. If these challenges were encountered in a favourable environment, they would likely be encountered in less favourable regions as well. The main implication is that other regional cooperations will likely face challenges such as domestic opposition, weak international cooperation in hydrogen R&D, overly lenient carbon emissions accounting, and exacerbated regional inequality.
Microwave Assisted Pyrolysis of Moringa Seed and Karanja for Bio-Oil Production
Authors: Ahmed Abu Saleh
Published: May 2024

Microwave-assisted pyrolysis is an alternative technique of conventional heating which undergo thermochemical process to convert biomass to bio oil, bio char and biogas. Microwave-assisted pyrolysis is more rapid and efficient to produce product compared to conventional heating. A modified household microwave oven with 800W was used to pyrolyze Moringa seed and Karanja to become bio oil and bio char. This experiment was repeated in different parameters such as time, temperature and power to obtain maximum bio oil yield. Bio oil yield of Moringa seed increased from 7.2 wt% at 300°C in 5 minutes to 10.6 wt% at 450°C in 13 minutes. Bio oil of both raw materials showed maximum yield when pyrolysis time is 13 minutes in 800W but after 13 minutes, the bio oil yield of Moringa decrease of 2.4% and bio oil yield of Karanja decrease of 4.7%. The calorific value of Moringa bio oil is 25.08MJ/kg whereas Karanja bio oil is 20.36 MJ/kg. Functional group of both bio oil mainly include alcohol, ketones, aldehydes and carboxylic acid. The pH value of Moringa bio oil and Karanja bio oil are 4.38 and 5.86 respectively.
Carbon Monoxide-Resistant Anode Catalysts for Single-Cell Direct Carbon Monoxide Fuel Cells: Platinum-Ruthenium Anode Electrocatalysts
Authors: Zabihian Farshid , Davari Asad , Osei-Prempeh Gifty
Published: May 2024

The objective of this paper is to present the results of experimentations on the state-of-the-art anode electrocatalysts and the membrane-electrode assemblies (MEAs) developed for direct carbon monoxide fuel cells (DCMFCs). The custom-made platinum-ruthenium (Pt-Ru) MEAs along with a commercial MEA were tested to evaluate the impacts of cell temperature, different types of fuel and oxidant, the flow rate of fuel and oxidant, and humidification temperature on the performance of the MEAs. It was shown that both the catalyst manufacturing process and the test procedure are repeatable. Also, it was shown that the performance of Pt-Ru cells when fueled by CO and CO-containing fuels was markedly inferior to that of hydrogen-fueled fuel cells. However, there were some promising signs that with the right catalysts and optimum operating conditions, the performance of DCMFCs can be significantly improved. It was also shown that increasing the operating temperature always improved the performance. While increasing the flow rates of the reactants improved the performance of the MEAs, there was a limit to this improvement. Furthermore, generally speaking, the performance of the MEAs was better when fed with CO rather than CO-N2 and O2 rather than air but the actual impact depended on other operating conditions.
Prime Editing in vivo: Correcting the Leptin Receptor of db/db Mice
Authors: Lee Kyung , Xu Yanping , Geng Bingchuan , Kim Jongsoo , Kellon Natalie , He Michele , Zhang Zhentao , Li Deqiang , Gouchoe Doug , Zhu Hua
Published: May 2024

Genetic diseases can be caused by monogenic diseases, which result from
a single gene mutation in the DNA sequence. Many innovative approaches
have been developed to cure monogenic genetic diseases, namely by genome
editing. A specific type of genomic editing, prime editing, has the
potential advantage to edit the human genome without requiring
double-strand breaks or donor DNA templates for editing. Additionally,
prime editing does not require a precisely positioned protospacer
adjacent motif (PAM) sequence, which offers flexible target and more
precise genomic editing. Here we detail a novel construction of a prime
editing extended guide RNA (pegRNA) to target mutated leptin receptors
in B6.BKS(D)-Leprdb/J mice (db/db mice). The pegRNA was then injected
into the flexor digitorum brevis (FDB) muscle of db/db mice to
demonstrate in vivo efficacy, which resulted in pegRNA mediated base
transversion at endogenous base transversion. Genomic DNA sequencing
confirmed that prime editing could correct the mutation of leptin
receptor gene in db/db mice. Furthermore, prime editing treated skeletal
muscle exhibited enhanced leptin receptor signals. Thus, the current
study showed in vivo efficacy of prime editing to correct mutant protein
and rescue the physiology associated with functional protein.
2-Hydroxyl hispolon reverses high glucose induced endothelial progenitor cell dysfunction through the PI3K/AKT/eNOS and AMPK/HO1 pathways
Authors: Wang Tajung , Hou Wen-Chi , Yang Chang-Hang , Liu Ju-Chi
Published: May 2024

Background and Purpose: In diabetes, elevated blood sugar (BS) levels
contribute to the overproduction of reactive oxygen species (ROS),
leading to endothelial progenitor cell (EPC) dysfunction. 2-hydroxy
hispolon (2HH), a derivative of Hispolon (HIS), shows potential in
reversing high glucose-induced EPC dysfunction. Experimental Approach:
In vitro, we inspected the effect of 2HH on three different angiogenic
cells, including outgrowth endothelial cell (OEC), circulating
angiogenic cell (CAC) and endothelial cell (EC). In vivo, High-fat diet
and streptozotocin induced diabetic mice and hindlimb ischemic model
were utilized to evaluate the effect of 2HH on angiogenesis and CAC
mobilization. Key Results: Treatment with 2HH significantly improved the
proliferation, migration, and tube formation, NO synthesis and ROS
diminishing of OEC under high glucose conditions. Moreover, 2HH
administration potentiates the AMP-activated protein kinase (AMPK)/heme
oxygenase-1 (HO-1) and phosphoinositide 3-kinases (PI3K)/protein kinase
B (AKT)/endothelial nitric oxide synthase (eNOS) signaling pathways in
OECs exposed to high glucose levels. Additionally, 2HH reverses high
glucose-induced impairment of CAC function but fails to restore EC
dysfunction under high glucose conditions. Hindlimb ischemic assay
demonstrated that 2HH treatment enhances blood flow recovery in ischemic
hindlimbs and increases the number of circulating CACs in diabetic mice
after femoral ligation. Conclusion and Implications: Our study has
demonstrated that 2HH effectively reduces oxidative stress, thereby
preventing EPC dysfunction induced by high glucose levels, primarily
through the PI3K/AKT/eNOS and AMPK/HO-1 pathways. These findings offer a
promising therapeutic avenue for attenuating the susceptibility to
critical limb ischemia in patients with diabetes.
Hypothalamic inflammation improves through bariatric surgery and hypothalamic volume predicts short-term weight loss response in adults with or without type 2 diabetes.
Authors: Pané Adriana , Videla Laura , Calvet Àngels , Viaplana Judith , Vaqué-Alcázar Lidia , Ibarzabal Ainitze , Rozalem-Aranha Mateus , Pegueroles Jordi , Moize Violeta , Vidal Josep , Ortega Emilio , Barroeta Isabel , Camacho-Marti Valle , Chiva-Blanch Gemma , Fortea Juan , Jiménez Amanda
Published: May 2024

OBJECTIVE: Preclinical research implicates hypothalamic inflammation (HI) in obesity and type 2 diabetes pathophysiology. However, their pathophysiological relevance and potential reversibility need to be better defined. We sought to evaluate the effect of bariatric surgery (BS) on radiologic biomarkers of HI and the association between the severity of such radiologic alterations and post-BS weight loss (WL)-trajectories. The utility of cerebrospinal fluid large extracellular vesicles (CSF-lEV) enriched for microglial and astrocyte markers in studying HI was also explored.

RESEARCH DESIGN AND METHODS: We included 72 individuals with obesity (20 with/52 without type 2 diabetes) and 24 controls. Participants underwent lumbar puncture and 3T magnetic resonance imaging at baseline and 1-year post-BS. We assessed mean hypothalamic diffusivity (MD) (higher values indicate lesser microstructural integrity) and the volume of the whole and main hypothalamic subregions. CSF-lEV enriched for glial and astrocyte markers were determined by flow cytometry.

RESULTS: Compared with controls, obesity and type 2 diabetes groups showed a larger volume and higher MD in the hypothalamic tubular inferior region, the area encompassing the Arcuate nucleus. These radiological alterations were positively associated with baseline anthropometric and metabolic measures and improved post-BS. A larger baseline tubular inferior hypothalamic volume was independently related to lesser WL one and two years after BS. CSF-lEV did not differ between groups and were unrelated to WL-trajectories.

CONCLUSIONS: These findings suggest HI improvement after BS and may support a role for HI in modulating the weight loss response to these interventions.
Discontinuation of imatinib in patients with oligometastatic gastrointestinal stromal tumour who are in complete radiological remission: a prospective multicentre phase II study
Authors: Hompland Ivar , Boye KJetil , Wiedswang Anne Marit , Papakonstantinou Andri , Røsok Bård , Joensuu Heikki , Bruland Øyvind
Published: May 2024

Introduction: Metastatic gastrointestinal stromal tumour (GIST) is considered incurable, and life-long treatment with tyrosine kinase inhibitors is recommended. We investigated whether selected patients with metastatic GIST may remain in durable remission despite imatinib discontinuation.
Patients: In this 1-group, prospective, multicentre phase II trial selected patients with oligometastatic (≤3 metastases) GIST discontinued imatinib treatment. Eligible patients had been treated with imatinib >5 years without progression and had no radiologically detectable metastases after metastasectomy, radiofrequency ablation (RFA) or complete response to imatinib. The primary endpoint was progression-free survival (PFS) 3-years after stopping imatinib. Overall survival (OS) and quality of life (QoL) were secondary endpoints.
Results: The trial closed prematurely due to slow accrual. Between January 5, 2017, and June 5, 2019, 13 patients were enrolled, of whom 12 discontinued imatinib. The median follow-up time was 55 months (range, 36 to 69) after study entry. Five (42%) of the 12 eligible patients remained progression free, and seven (58%) progressed with a median time to progression 10 months. Median PFS was 23 months and the estimated 3-year PFS 41%. Six of the seven patients who progressed restarted imatinib, and all six responded. Three-year OS was 100%, and all patients were alive at the time of the study analysis. QoL measured 5 and 11 months after discontinuation of imatinib demonstrated improvement compared to the baseline.
Interpretation: A substantial proportion of selected patients with oligometastatic GIST treated with imatinib and metastasis surgery/RFA may remain disease-free for ≥3 years with improved QoL after stopping of imatinib.
An Explorative Study on Calcium Electroporation for Low-risk Basal Cell Carcinoma
Authors: Wiegell Stine R. , Hendel Kristoffer , Fuchs Christine S.K. , Gehl Julie , Vissing Mille , Bro Sara W. , Troelsen Jesper T. , Jemec Gregor B.E. , Haedersdal Merete
Published: May 2024

In electrochemotherapy, permeabilization of the cell membrane by electric pulses increases the anti-tumour effect of chemotherapeutics. In calcium electroporation, chemotherapy is replaced by calcium chloride with obvious benefits. This study explores the effect and underlying mechanisms of calcium electroporation on basal cell carcinomas using either high- or low-frequency electroporation. Low-risk primary basal cell carcinomas were treated in local anaesthesia with intratumoral calcium chloride followed by electroporation with high (167 kHz) or low (5 kHz) frequencies. Non-complete responders were retreated after 3 months. The primary endpoint was tumour response 3 months after last calcium electroporation. Plasma membrane calcium ATPase was examined in various cell lines as plasma membrane calcium ATPase levels have been associated with calcium electroporation efficacy. Twenty-two out of 25 included patients complete the study and 7 of these (32%) achieved complete response at 3 months with no difference in efficacy between high- and low-frequency pulses. High-frequency calcium electroporation was significantly less painful (p=0.03). Plasma membrane calcium ATPase was increased 16–32-fold in basal cell carcinoma cell lines compared with 4 other cancer cell lines. Calcium electroporation for low-risk basal cell carcinomas does not fulfil the requirements of a new dermatological basal cell carcinoma treatment but may be useful as adjuvant treatment to surgery in more advanced basal cell carcinomas. The elevated PMCA levels in basal cell carcinomas may contribute to low efficacy.
A Profile of Modern Hunters in Burdur Province, Türkiye and Compared to European Data
Authors: Aksan Şengül , Y Yıldırım
Published: May 2024

This study aimed to investigate the socio-demographic characteristics of hunters in Burdur province in Türkiye based on the data of the Game Management Information System (AVBIS) being overseen by and under the control of the General Directorate of Nature Conservation and National Parks, the Ministry of Agriculture and Forestry of Türkiye. Hunter educational status, and their professional status were determined using the chi-squared test. In the light of the data obtained from a total of 3185 hunters, the group with the primary school level 36.4%, secondary school 10.9%, high school 15.6%, associate 3.1%, undergraduate 8.0%, master's degree 0.8%, doctoral degree graduates 0.1% and the unknown educational status were determined to be 25% (P<0.01). Considering the professional status, it has been determined that the largest share among occupational groups consists of 33.8% of self-employed and 23% of public sector employees, followed by 17.5% of tradesmen and 15.4% of retirees. Occupational groups with the lowest rate 1.7% the private sector, 1.3% students, and 0.3% industrialists with (P<0.01). A comparison of data regarding hunting grounds and the number of game animals hunted was made with Anova-Duncan. It was revealed that for gaming the hunters visited highest catch in the hunting grounds of Burdur province was 45.4% in Kemer (P<0.05). The lowest catch was found in Pamucak with 9.76%. The most hunted animal species in the hunting grounds of Burdur Province were found as 96.45% C. livia (P<0.01) and S. rusticola and G. gallinago species is quite low compared to other animal species. As is evident from this study, socio-demographic profiles of hunters in Burdur province, Türkiye, and in Europe appear to be similar. A significant difference was observed in terms of the number of female hunters. While the average of female hunters in some European countries reached 10,5% there is no female hunter registered in the AVBIS in Türkiye.
Prospects for Livestock Nutrition in the View of COVID-19
Authors: Attia Youssef , AF Khafaga , CS Thompson
Published: May 2024

Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a global pandemic. Remarkable negative impacts of the pandemic have already been observed in ecosystems, human civilization, food security and safety, and global environments. In addition, various sectors involved in the food production chain, particularly the agricultural and livestock sectors, also severely affect food production, food security, food safety, as well as cause economic loss. A sharp reduction in the production of meat, milk, eggs, etc., as a consequence of the global pandemic, has already been well documented. Movement restrictions were imposed locally and internationally as part of the COVID-19 control strategy. As a result, businesses related to the supply of raw materials to livestock, farmers, farm output, veterinary services, and farm workers have dramatically decreased. So has animal welfare. A few months have passed since the Centers for Disease Control and Prevention (CDC) officially announced the COVID-19 pandemic over and the food chain has not yet recovered. This review highlights the prospects of livestock nutrition in view of the COVID-19 crisis for global pandemic prevention.
The Close and Multiple Relationship between Health and Development
Authors: Leal Daniela de Ulysséa
Published: May 2024

Health and development are linked concepts. The pioneering studies of Samuel H. Preston (1975) showed a strong, positive and non-linear correlation between life expectancy (longevity) and the per capita income of countries at three different times (1900s, 1930s and 1960s)
The Association of Asthma with Onset of Dementia-An Initial Exploration by Meta-Analysis
Authors: Zhi Xinyue , Y Ren , Z Zhang , Y Fang , JM Jonassond , P Tiwar
Published: May 2024

Objective: A meta-analysis was performed to assess the association between asthma and dementia, aimed to provide initial exploration for further etiolotical/preventive/clinical discussion. Methods: A systematic search of Pubmed, Embase, Web of Science and Cochrane library databases was conducted to screening evidence. Cohort/case control studies that are focused on the association between asthma and the onset of dementia were identified in the current meta-analysis. The search time frame was from database establishment to August, 1st, 2023, with independent reviewers screening the literature. The quality of the literature was evaluated by Newcastle-Ottawa Quality Assessment Scale (NOS). R 4.3.2 was used in data analysis. Results: 9 studies including 234248 participants were included. The overall quality of the included studies was high, with an average NOS score of over 8. The results of the meta-analysis in the current study confirmed that there is an association between asthma and cognitive dysfunction. It is noteworthy that the significant association was found between all-severity levels-of-asthma and the risk of onset of all-types-of-dementia when we define it as dichotomous variable. Moreover, subgroup analysis revealed a high risk of dementia in specific asthma patients. Conclusion: Our findings showed a significant increase in the risk of dementia among patients with asthma, and this risk is not affected by the types of dementia, however it seems especially obviously among specific asthma patients.
Have Countries Ignored Infertility for Too Long? - India Case Study
Authors: Kishanrao Suresh
Published: May 2024

Fertility has been one of man’s desired attributes since the beginning of recorded history and remains a driving need for young couples to prove their fertility as soon as possible after marriage. Though this trend is changing a bit over a decade, due to some people with higher education, getting married late, working couple and some who are intentionally delaying parenthood. In India, pregnancy is usually viewed as a normal physiologic phenomenon, that does not require any intervention by professionals, unless there is some problem in conceiving, or pregnancy going to full term or in birthing. Most Indian families believe that they have little or no control over their pregnancies or outcomes. The importance of motherhood in traditional patriarchal cultures is rooted in the teachings of all the religions. The World Health Organisation (WHO) has recognised infertility as a public health issue. Although biological factors are the primary cause, factors like social, health, and lifestyle factors do have an adverse effect on a couple’s ability to reproduce. The current fertility rate for India in 2024 is 2.122 births per woman, in 2023 it was 2.139 births per woman, in 2022 it was 2.159, in 2021 = 2.179 births per woman, and 2.159 in 2020, witnessing a reduction of 0.95% each year. Replacement level fertility needed to maintain a stable population size, is estimated to be 2.1. below which the population starts declining as we see in China (1.705 in 2023) today. High levels of infertility will generate low desire for contraception. Fertility and infertility are social conditions which are intricately connected. Where fertility is highly valued, infertility will conversely be devalued. Infertile across Indian women in 2019-21 (NFHS-5) by duration of marriage varied from i) women married for ≥1 year = 42.9%, ii) married for ≥2 years =30.7% Married for ≥3 years =24.1%, married duration ≥4 years =20.7% and married for ≥5 years = 18.7%. Age at marriage, biological factors, and lifestyle factors are strongly linked to infertility. People with higher education levels, late marriages, working couple and those intentionally delaying parenthood are more likely to experience primary infertility. Materials and Methods: This article is based on authors experience of guiding four cases of primary sterility in last 5 years. For different reasons first case has succeeded, second is progressing towards success, third is 30% hopeful as the cause is not necessarily associated with infertility and in the fourth all efforts have failed except IVF which the couple could not afford. The case studies suggest that Infertility in India needs to be Public Health Concern!
Awareness of Endemics Fighting Agents about Sun Exposure
Authors: Machado Diego Gimenez
Published: May 2024

Introduction: Sunlight plays a crucial role in sustaining human life, however, its impacts vary according to factors such as duration of exposure, intensity and frequency. These impacts can be beneficial, such as the synthesis of vitamin D and the stimulation of melanin production, which have positive effects on the human body. However, inadequate and unprotected exposure to solar radiation can cause damage to the body, such as premature aging and, ultimately, the development of skin cancer. The objective of this study was to analyze whether awareness had an impact on the habits of Endemic Disease Control Agents in the municipality of Ourinhos-SP in relation to sun exposure. Method: The research was carried out using a questionnaire on sun exposure and photoprotection, which contains 11 questions regarding photoprotection and sun exposure habits, applied to 27 (twenty-seven) agents combating endemic vector diseases, in Ourinhos- SP, after a period of two months, the same questionnaire was administered again. Results: A total of 14.8% of participants do not apply sunscreen daily, while 40.7% of those who use sunscreen apply it twice a day and 92.6% use a hat, cap or visor as a protective measure against sunscreen. sun exposure. Conclusion: It is concluded that, despite the high risk of developing skin cancer, these professionals demonstrate greater awareness.
Public Policies for Health Promotion in Brazil: A Look at Dengue Control
Authors: Leal Daniela de Ulysséa
Published: May 2024

In 2024, Brazil recorded more than a thousand deaths from dengue in the first thirteen weeks of the year, the third highest number since the beginning of the historical series in 2000. On the same date, eleven Brazilian states declared an emergency because of dengue fever
Comparison of Doppler Guided Seldinger Technique Versus Classic Palpatory Seldinger Technique for Radial Artery Cannulation-an Open Label Randomized Controlled Trial
Authors: G* Neha
Published: May 2024

Objective: Radial artery cannulation is commonly performed by the conventional palpatory technique. However, in circumstances where the cannulation is difficult, other methods such as Doppler or ultrasound are used to guide the cannulation. Incorporating the Seldinger technique can further improve the successful cannulation. The aim of the study was to compare the first attempt success rate of radial artery cannulation between conventional palpatory Seldinger technique and Doppler guided Seldinger technique. Methods: Ninety patients undergoing major open abdominal surgeries were divided into two groups -the Classic palpatory and the Doppler guided radial artery cannulation. The Seldinger Technique was used in both the groups. First attempt success rate of radial artery cannulation and time to cannulation were noted by both the techniques. Results: The number of attempts and the time to cannulation were significantly less in the palpatory Seldinger group as compared with the Doppler Seldinger group. Complication rates were similar in both the groups but there were 4 failure in palpatory Seldinger group. Conclusion: The classic palpatory technique along with the Seldinger technique for radial artery cannulation is better in terms of first attempt cannulation rate and duration of cannulation than the Doppler guided Seldinger technique in patients undergoing elective surgeries. However, Doppler method had no failures and can be a useful rescue method in failed cannulation.
O IMPACTO DA TECNOLOGIA NO PROCESSO DE ALFABETIZAÇÃO: DESAFIOS E OPORTUNIDADES
Authors: Mafra Mackson Azevedo , Carvalho Núbia Costa , Alves Cleny Ferreira , Silva Éverton Marques da , Azevedo Celine Maria de Sousa , Floriano Maria Bárbara , Caetano Athyla , Malta Daniela Paula de Lima Nunes
Published: May 2024

Este estudo abordou o impacto da tecnologia no processo de alfabetização, enfocando os desafios e oportunidades que surgem com a integração de tecnologias digitais na educação infantil. O objetivo geral foi explorar como essas tecnologias afetam a alfabetização e identificar maneiras de transformar os desafios em oportunidades para enriquecer a experiência educacional. Adotou-se uma metodologia de revisão bibliográfica, com critérios específicos de seleção que incluíram a relevância, a atualidade e a qualidade metodológica dos estudos analisados. Os resultados revelaram que, embora existam barreiras significativas, como a equidade no acesso às tecnologias e a necessidade de formação docente adequada, há também um grande potencial para as tecnologias digitais promoverem uma aprendizagem mais inclusiva e personalizada. As considerações finais destacaram a importância de investir na capacitação dos educadores e no desenvolvimento de estratégias de ensino adaptáveis, visando maximizar os benefícios das tecnologias digitais na educação. Concluiu-se que a integração efetiva dessas tecnologias representa uma oportunidade significativa para avançar na qualidade da educação infantil.
SUSTENTABILIDADE DIGITAL: COMO A TECNOLOGIA PODE IMPULSIONAR PRÁTICAS SUSTENTÁVEIS
Authors: Caldeira Vanessa Morgado Madeira , Souza Átila de , Araújo Karine do Nascimento , Gomes Ivanilda de Argolo , Medeiros Geisiélli Aparecida Carvalho Marin de , Caiado Magno Antonio Cardozo , Amaral Rejane da Silva , Marcondes Pollyanna
Published: May 2024

Este estudo explorou a intersecção entre tecnologia e sustentabilidade, focando no problema de como a digitalização pode contribuir para práticas sustentáveis. O objetivo geral foi analisar o papel das tecnologias digitais na promoção da sustentabilidade em diversos contextos, desde a educação até o impacto ambiental das empresas. Utilizando uma metodologia de revisão bibliográfica, o trabalho reuniu e analisou estudos anteriores que abordaram desde a definição e evolução do conceito de sustentabilidade digital até exemplos práticos de sua aplicação. Os resultados demonstraram que, apesar de existirem desafios significativos, como o alto custo de implementação e a resistência à mudança, existem também inúmeras oportunidades para que a tecnologia atue como facilitadora de práticas sustentáveis. Através da análise de casos de sucesso, foi possível identificar como a integração efetiva da tecnologia em estratégias sustentáveis pode resultar em benefícios ambientais, sociais e econômicos significativos. As considerações finais reiteraram a importância da colaboração entre governos, setor privado e sociedade civil para superar as barreiras à implementação de tecnologias sustentáveis e destacaram as tendências futuras que indicam uma convergência crescente entre tecnologia e sustentabilidade.
Letramentos
Authors: Teixeira Aline Thomaz de Oliveira , Moraes Fernanda Beatriz Caricari
Published: May 2024

Este trabalho apresenta a elaboração de estratégias de Letramento Visual na educação de alunos surdos e tem por finalidade mostrar sugestões de materiais para compor uma sala de leitura multimodal, naperspectiva bilíngue, intitulada “Espaço de Letramento”. A proposta é de desenvolver um espaço de convivência online, o qual reúne exemplares da Literatura Surda de diferentes gêneros textuais, comabordagem bakhtiniana de gêneros discursivos, e representações artísticas, que expressam suasexperiências nesses meios. O trabalho agrega duas grandes temáticas, o letramento ancorado na perspectiva dos multiletramentos (NLP, 1996) e o ensino de Língua Portuguesa como segunda língua para surdo. Portanto, espera-se que essa proposta de letramento on-line colabore para o desenvolvimento do aprendiz surdo em LP e Libras, fomentando o sujeito dialógico.
Poesia em sala de aula
Authors: Nascimento Rafaela Menezes Melo , Queiroz Amilton José Freire de
Published: May 2024

O presente trabalho analisa sob a perspectiva decolonial, a poética da Negritude feminina contemporânea. Onde, se propõe o poema como horizonte de recepção e circulação das diásporas negras, para ampliar as possibilidades de abordagens das literaturas São- Tomense e Afro-brasileira em sala de aula. Como corpus de análise, tem-se “Vozes- Mulheres” de Conceição Evaristo (2017) e “Canto obscuro às raízes” de Conceição Lima (2006). Poemas, cuja dimensão lírica, dramática e simbólica mapeiam uma escritura do corpo e itinerários transfronteiriços com imagens poéticas distendidas, desvelando um mosaico intertextual, intercultural e intersemiótico das vozes da negritude hoje. Para examinar essa questão, adotamos as reflexões de Amâncio (2023) Ballestrin (2013) Bernd (2010), Candido (2006), Cosson (2009), Duarte (2011), Figueiredo (2013), Goulart (2022), Mignolo (2003) e Walsh (2013). Além disso, são sugeridas propostas didático-metodológicas que abordam a educação antirracista por meio da Literatura Afrodescendente, destacando um eu-lírico que tece diásporas, memórias, tradições e saberes, dando voz à mulher negra no âmbito familiar, social e literário.
Utilization of Biomethane to Support Energy Security in Indonesia, Riau Province: A Case Study
Authors: Fahrudin Ali , Hakam Dzikri Firmansyah , Prawiraatmadja Widhyawan
Published: May 2024

As the largest global palm oil producer, Indonesia contributes 59% to the world’s palm oil supply, producing 46.9 million tons of Crude Palm Oil (CPO) in 2021. However, this extensive production poses an environmental challenge through Palm Oil Mill Effluent (POME), estimated at 156 million m3 annually. POME treatment facilities release Biogas, predominantly Methane (CH4) at 50%–75%, a potent Greenhouse Gas (GHG) with 21 times the global warming potential of CO2. Conversely, Methane is a key component of widely used Natural Gas. Properly treated, POME-derived biogas can be upgraded to Biomethane, a clean and carbon-negative alternative for the Natural Gas Grid or fossil fuel substitution, estimated at 1,280 MWe, equivalent to 288 MMSCFD CH4. Despite Biomethane’s potential, its utilization remains limited to self-use in Palm Oil Mills or power plants, even in Riau Province, home to Indonesia’s largest oil palm plantation. PT Perusahaan Gas Negara Tbk survey identified potential customers in Riau willing to adopt natural gas, hindered by infrastructure and economic scale challenges. This research analyzes obstacles to biomethane business development in Indonesia, focusing on Riau Province, aiming to formulate an optimal distribution scheme and sustainable strategies. Methodologically, a mix of quantitative and qualitative data collection techniques, including literature studies, interviews, and questionnaires, informed a comprehensive analysis employing geographical, transportation cost, financial modeling, SWOT, and risk analyses. Findings suggest trucking as the optimal distribution mode for biomethane to scattered customers. Economic viability hinges on biomethane volume, necessitating stability and increased sales volume strategies. For Riau, four potential customers with a total daily demand of 11,248.93 m3 can be served affordably by selecting palm oil mills within a 76 km radius. Price and security supply considerations are crucial. This research provides insights into overcoming challenges and optimizing the biomethane business in Riau, offering a sustainable model for broader adoption in Indonesia.