bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of circuit rhythms disturbances on the clinical picture of the disease in patients with metabolic syndrome
Authors: Gribanov I. A. , Zarubina E. G.
Published: February 2023

The purpose of this study was to evaluatey the effect of dark deprivation of various durations on the course of the metabolic syndrome (MS).

Material and research methods. To achieve this aim, based on WHO criteria, we selected patients with MS and disturbed circadian rhythms – a total of 102 people (all men) from among people who constantly work at night, in whom a decrease in melatonin levels was recorded at a preliminary stage. In accordance with the tasks set, 102 patients (all men) of working age (young age according to WHO criteria) were divided into three groups of 33, 37 and 32 people, respectively, according to the criterion "duration of work at night and duration of history of MS": 0–5, 5–10 and over 10 years. In the first group, the mean age was 30.1 ± 1.4 years; in the second group, the mean age was 36.5 ± 1.5 years; in the third group, the mean age did not exceed 40.3 ± 0.9 years. As a control group, 45 patients with MS were examined, comparable with the main groups in terms of background pathology and age and different duration of MS history.

Results. It was found that the main symptom of MS - abdominal type of obesity (waist circumference more than 80 cm for men) was detected in 100% of patients of the main and control groups of observation. At the same time, it was found that the severity of abdominal obesity is combined with an increase in body mass index (BMI) and tends to increase in patients in the main groups, compared with patients from the control group. In the control group, 35.5% of the examined patients had grade 1-2 hypertension, and another 15.6% had elevated normal blood pressure.

Conclusions: In patients with MS, against the background of violations of regulatory mechanisms, the disease is more severe than in patients with a similar history of MS, but without violations of circadian rhythms. The severity of the course of MS against the background of a decrease in the level of melatonin increases with the duration of the violation of regulatory mechanisms.
The results of bacterial contamination of dangerous and borderline cases of burns
Authors: Tolstov A. V. , Novikov I. V. , Milyudin E. S. , Yunusov R. R. , Kivaeva O. I.
Published: February 2023

The aim is to study the microbiological picture of purulent inflammation of superficial local burns in the center of thermal lesions of Samara.

Material and methods. The etiological structure of local burn infection was analyzed in 29 patients with limited, borderline burns of I-II degree in all phases of the wound process. The collection of wound material was carried out in accordance with the requirements of the Methodological Guidelines of MU 4.2.2039-05 "Technique of collecting and transporting biomaterials to microbiological laboratories". The material was delivered to the laboratory in test tubes with a transport medium under isothermal conditions at a temperature of 20–22 °C within a day after collection.

Results. The analysis of the etiological structure of burn infection showed that staphylococcus (St. aureus, St. warneri, St. gallinarium, St. spp, St. epidermidis) plays a leading role in microbiological examination – in 26 patients (89.6 %) and E. coli (E. coli) in 11 (37.9 %). There were no significant differences in the studied signs in the comparison groups (p > 0.05, p = 0.55, χ2 = 3.841).

Conclusion. The obtained results of the etiological structure of purulent inflammation of limited burns are statistically reliable and can be used in the development of antibacterial agents for the treatment of burn infection.
O pronome pleno no português afro-brasileiro em construções de ODA
Authors: Sousa Lílian Teixeira de , Figueiredo Cristina
Published: February 2023

Neste artigo, discutimos a possibilidade de a aquisição do pronome pleno (PP) no português por africanos como L2 ter sido resultado da seleção e competição de traços (MUFWENE, 2008; ABOH, 2015) durante o período de colonização do Brasil, devido ao multilinguismo ocorrido, principalmente entre o português e as línguas africanas do grupo Banto. Propomos que os traços de concordância de pessoa e gênero, através do sistema de classificadores, nas línguas do grupo Banto tenha sido o input para a seleção do PP na retomada de um DP com a seguinte combinação de traços [+animado, +humano], traços que também estão presentes na partícula anexada ao verbo dessas línguas. Para testar essa hipótese, foram analisados dados de quatro comunidades afro-brasileiras do estado da Bahia, que vivem em relativo isolamento: Helvécia, Arraiais de Rio de Contas, Cinzento e Sapé. Assume-se que o objeto nulo (ON) nas primeiras situações de contato tenha sido a estratégia eleita para retomada de um DP na posição de objeto direto em todos os contextos semânticos possíveis e que o PP tenha sido adquirido posteriormente durante as sucessivas situações de contato que se repetiam devido à constante chegada de navios negreiros durante os três primeiros séculos de colonização do Brasil, o que levou à aquisição do português como L2 em diversos momentos da história.
Development Potential of Russian and Kazakh Agricultural Exports to China
Authors: Karlova N. , Payurova E.
Published: February 2023

Due to their vast territory suitable for agriculture, surplus production of agricultural products and geographical proximity to the northern and western provinces of China, Russia and Kazakhstan can take significant positions in the growing Chinese market. The development of international transport corridors with access to China will contribute to the increase of the competitive capabilities of the two countries and the growth of export volumes. In this context, the interstate railway corridor with Dostyk border station (Kazakhstan) as a connecting link seems very promising. The development of this direction of agro-logistics will contribute to the inclusion of Siberian and Ural regions of the Russian Federation in international trade, will be an important factor in the international role of the Republic of Kazakhstan by attracting transit cargo from Russia. The transport corridor through Dostyk is also relevant in the context of sanctions against Russia and the need to reorient trade flows with unfriendly countries to other directions. The article identifies the types of agricultural products and regions of the cargo area that are the most promising for exports from Russia and Kazakhstan through Dostyk. To assess the potential for the development of this transport corridor, the analysis of agricultural cargo export flows from Russia and Kazakhstan to China in terms of ports and border crossings is presented, the problems and bottlenecks of agro-export logistics of Russia and Kazakhstan are studied, the economic efficiency of traditional railway and container transportation is compared, and the competitiveness of Russian agricultural products supplies to China through Dostyk in comparison with other logistics directions is estimated. The findings indicate that the regions of the cargo zone of Russia and Kazakhstan have high shipping potential for railway deliveries to China through Dostyk. However, its implementation is possible under a number of conditions: changes in railway transportation tariffs and removal of export restrictions, while intensifying negotiations between countries with China to reduce the level of customs and administrative barriers.
On Certain Research Approaches to the World Information and Communication Order
Authors: Snapkovskii V. , Fedotov L.
Published: February 2023

The article analyzes new trends and features of development of the World Information and Communication Order (WICO). Particular attention is focused on scientific approaches of Russian and Western authors to modern problems of international communication. The role and place of WICO in the world order are shown. While in the 1970–1980s, the disputes around the establishment of the New World Information and Communication Order (NWICO) used to be a popular object of investigation in political, social and legal sciences, this interest died away as soon as NWICO ceased to be a factor in global political debates. However, the authors reject the attitude towards NWICO as being merely a historic phenomenon, because it has been referred to in the UN General Assembly acts until recently. As soon as the world order incorporates the urge for an ideal and objective reality, NWICO is considered as an indispensable part of WICO. In the article, WICO is regarded as a sub-system of the world political order and world economic order, which is greatly influenced by the developments experienced by the latter. In the meantime, WICO itself contains at least four sectoral sub-systems which have reached different levels of evolution: the technical cooperation sub-system, the economic sub-system, the content sub-system and the security sub-system. As far as approximately 55 regional organizations have established their cooperation frameworks in the information and communication field, WICO contains a highly developed regional sub-system which in many cases has reached much more advanced levels than the global WICO. The authors analyze the influence on WICO exerted by such trends in the world order system as non-state actors’ strengthening and the expansion of the order’s comprehensive rules on national policies’ spheres. The WICO evolution is shown as a continuous process throughout which its rules have emerged in the growing number of segments of the information and communication sphere, fueled, on the one hand, by the progress in information receiving, transfer, storage and processing and, on the other hand, by developments in the world political order and world economic order. According to the article, from the middle of the 19th century until early 21st century, this evolution had passed seven stages. The authors expect the upcoming switch to the realistic approach in the further development of WICO, which presupposes a restriction of its rules to those issues, which can be a subject to broad international consensus.
A Study on Community Vitality using Combined Overlap Block Fuzzy Cognitive Maps
Authors:   M.Phil Mathematics, Department of Mathematics, Loyola College, Chennai, India, Mr S.Santhakumar , Devadoss A.Victor ,   Head & Associate Professor, Department of Mathematics, Loyola College, Chennai-34, India, Mr D.Ajay ,   Ph.D Research Scholar, Department of Mathematics, Loyola College, Chennai-34, India
Published: February 2023

In this paper, we analyzed about vitalizing the community using COBFCMs which was defined by W.B.Vasanthakandasamy. The Combined Overlap Block FCMs defined in this method becomes effective when the number of concepts can be grouped and are large in numbers. Community vitality is one of the factors for happiness of the people. It has become very important to vitalize the communities. This paper has five sections. First section gives the information about development of Fuzzy Cognitive Maps and Community Vitality. Second section gives preliminaries of Fuzzy Cognitive Maps and Combined Overlap Block Fuzzy Cognitive Maps. In section three, we explain method of determining the hidden pattern. In the fourth section, we give the concepts of problem. Final section gives the conclusion based on our study.
Primitive vs. Advanced Theory-of-Mind: Defending and Reformulating the Difference
Authors: Bejarano Teresa
Published: February 2023

Abstract. Can we nowadays keep a qualitative difference between the primitive and advanced Theory-of-Mind? The old criteria have become blurry. In addition, it is clear that in ‘apes’ lifestyle’ it is not necessary to use the communicative-cognitive basic abilities which became indispensable in ‘the new lifestyle’. Thus, it is usual to conclude that apes would have to some degree such abilities. However, this article tries to reformulate and defend that qualitative difference. Thus, after underlining the contrast between two kinds of mental states (‘contents’ and ‘expectations’), I apply it to the detection of foreign mental states as well. Then, three points are proposed: First, ‘vicarious expectations’ sustain the primitive ToM; second, a subject can have no expectation of inner states which are intrinsically impossible for him; third, the state of interacting with ourselves as with a different person –e.g., the thinking what others think of us– cannot be a vicarious expectation of ours, but it requires the estimation of foreign contents. From this hypothesis, I deduce that vicarious expectations are unable to sustain self-conscious emotions or the really effective reception of pointing gestures. These abilities could appear only when ‘the estimation of foreign contents’ –i.e., the origin of the advanced ToM– arose.
Ventilation Strategies for Mitigating Airborne Infections in Healthcare Facilities: A Mini-Review and Bibliometric Analysis (1970 to 2021)
Authors: Saupi Syahmi Bazlisyam Mohd , Kek Hong Yee , Tan Huiyi , Othman Mohd Hafiz Dzarfan , Nyakuma Bemgba Bevan , Goh Pei Sean , Altowayti Wahid Ali Hamood , Qaid Adeb , Wahab Nur Haliza Abdul , Lee Chia Hau , Lubis Arnas , Wong Syie Luing , Wong Keng Yinn
Published: February 2023

Over the years, researchers have been developing different ventilation strategies as a potential solution for controlling infectious airborne transmissions in healthcare facilities. The effects of ventilation systems on airflow characteristics have been extensively discussed among researchers since SARS-CoV-2 outbreak in 2019. Based on a bibliometric study of 154 publications from 1970 to 2021 retrieved from the Web of Science (WoS) database, this paper examines the research landscape on the effects of ventilation strategies on airflow analysis in healthcare facilities. Results show that China is the most productive country due to its significant contributions to the top prolific authors and funding agencies, which have promoted the research development of the topic. Several research hotspots were identified through keyword co-occurrence analysis. Cluster 1 highlights the ventilation studies involving ventilation layouts and ventilation rates in healthcare facilities. Cluster 2 underlines the computational analysis of ventilation performance for reducing the exposure risk of occupants, which promotes the development of infection control measures. Cluster 3 strengthens the knowledge of the emission and dispersion characteristics of respiratory droplets in healthcare facilities. Overall, this paper highlights the future direction of the current research field other than identifying strategic collaborators and suitable publication outlets for interested researchers.
DOMINUS LITIS DALAM PENGHENTIAN PENUNTUTAN BERDASARKAN KEADILAN RESTORATIF (Studi Kasus di Kejaksaan Negeri Surakarta)
Authors: Monica Candra Apriliana Georgia
Published: February 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui alasan penuntut umum melakukan penghentian penuntutan terhadap kasus tindak pidana penganiayaan yang terjadi dalam wilayah hukum Kejaksaan Negeri Surakarta serta pertimbangan penuntut umum sebagai fasilitator perdamaian dengan menggunakan asas dominus litis sebagai asas penuntut umum dalam bertindak atas kasus yang ditangani serta dilandasi Peraturan Kejaksaan Republik Indonesia Nomor 15 Tahun 2020 tentang Penghentian Penuntutan Berdasarkan Keadilan Restoratif. Metode penelitian yang digunakan adalah penelitian hukum normatif. Sumber dan bahan hukum yang digunakan adalah bahan hukum primer dan bahan hukum sekunder, teknik analisis bahan hukum menggunakan metode silogisme dan interpretasi dengan menggunakan pola pikir deduktif. Berdasarkan hasil penelitian yang penulis lakukan, diketahui bahwa alasan penghentian penuntutan oleh penuntut umum atas tindak pidana penganiayaan yang tercantum dalam Surat Ketetapan Penghentian Penuntutan Nomor: B-1349/M.3.11/Eoh.2/06/2022 telah sesuai dengan Peraturan Kejaksaan Republik Indonesia Nomor 15 Tahun 2020 tentang Penghentian Penuntutan Berdasarkan Keadilan Restoratif, sehingga sah dan meyakinkan penghentian penuntutan yang dilakukan oleh penuntut umum telah tepat dilakukan secara keadilan restoratif berdasarkan syarat-syarat yang telah terpenuhi.
Kata kunci: Keadilan restoratif; penghentian penuntutan; tindak pidana penganiayaan
PENGATURAN PEMBEBANAN RESTITUSI TERHADAP PELAKU ANAK SEBAGAI BENTUK PERTANGGUNGJAWABAN KERUGIAN TERHADAP KORBAN TINDAK PIDANA
Authors: Yossafa Satriadjie Abdee
Published: February 2023

Penelitian ini bertujuan untuk menganalisis mengenai pengaturan pembebanan restitusi terhadap pelaku anak sebagai bentuk pertanggungjawaban kerugian terhadap korban tindak pidana. Penelitian ini difokuskan untuk mengkaji penerapan hukum acara pidana pada putusan Nomor : 15/Pid.Sus-Anak/2021/PN Yyk yang dalam putusannya hakim membebankan restitusi kepada pelaku anak. Jenis penelitian ini adalah penelitian normatif dengan pendekatan kasus (Case Approach). Bahan hukum yang digunakan adalah bahan primer yang meliputi berbagai jenis peraturan perundang-undangan yang mempunyai sifat autoritatif termasuk putusan dan bahan hukum sekunder. Pengumpulan bahan hukum penelitian ini menggunakan studi kepustakaan. Berdasarkan hasil pembahasan, bahwa putusan Nomor : 15/Pid.Sus-Anak/2021/PN Yyk secara formil sudah mengakomodir hak-hak korban tinak pidana dengan dikabulkannya permohonan restitusi namun putusan tersebut belum sepenuhnya mengakomodir hak-hak anak dikarenakan belum ada pengaturan mengenai pelaku anak yang dapat dibebani restitusi sehingga diperlukan keseimbangan (Balance) antara perlindungan hukum korban dan pelaku anak.
PERTIMBANGAN HAKIM PENGADILAN NEGERI SUKOHARJO DALAM MEMUTUS PERKARA TINDAK PIDANA KEKERASAN SEKSUAL
Authors: Assidiqi Rafli , Rustamaji Muhammad
Published: February 2023

Artikel ini menganalisis Hukum Acara Pidana terkait kekerasan seksual terhadap anak dibawah umur ditinjau dari perlindungan hukum korban. Tujuan artikel ini adalah untuk mengetahui bagaimana pertimbangan hakim dalam memutus perkara kekerasan seksual terhadap anak dibawah umur. Metode penelitian yang digunakan adalah penelitian hukum doktrinal atau normative. Penelitian ini bersifat preskriptif dan terapan. Pengumpulan bahan hukum dengan studi kepustakaan dan bahan hukum yang digunakan adalah bahan hukum primer dan sekunder. Berdasarkan hasil penelitian dapat disimpulkan bahwa Majelis Hakim dalam memutus perkara dalam putusan Nomor: 82/Pid.Sus/2022/Pn Skh menggunakan dakwaan alternatif kedua, dimana Majelis Hakim berpendapat bahwa dakwaan yang seharusnya digunakan adalah dakwaan subsidair dan Majelis Hakim tetap memberikan putusan pemidanaan karena hakim memiliki keyakinan bahwa terdakwa dalam melakukan tindak pidana persetubuhan diawali dengan bujuk rayu kepada korban. Majelis Hakim dalam menjatuhkan putusan pemidanaan juga memperhatikan perlindungan hukum korban dengan mempertimbangkan pada Unsur yang memberatkan terhadap terdakwa.
Zespół Turnera w aspekcie współistniejących zaburzeń neurologicznych
Authors:   Katedra i Klinika Neurologii Dziecięcej, Śląski Uniwersytet Medyczny w Katowicach, Gawlik Aneta , Tokarska Agnieszka ,   Katedra i Klinika Pediatrii i Endokrynologii Dziecięcej, Śląski Uniwersytet Medyczny w Katowicach, Paprocka Justyna ,   Katedra i Klinika Neurologii Dziecięcej, Śląski Uniwersytet Medyczny w Katowicach
Published: February 2023

Zespół Turnera (ang. Turner’s syndrome, łac. syndroma Turner) spowodowany jest całkowitym lub częściowym brakiem jednego z chromosomów X we wszystkich komórkach organizmu lub w pewnej ich części. Występuje u 1 na 2000 – 2500 żywo urodzonych noworodków płci żeńskiej. Jest jedną z najczęstszych aberracji chromosomowych. Szerokie spektrum problemów zdrowotnych w tym zespole nakłada obowiązek zapewnienia pacjentce wielospecjalistycznej opieki medycznej Artykuł oparty jest na przeglądzie najnowszej literatury, a jego celem jest zwrócenie uwagi na to, że zaburzenia neurologiczne w tym neuropsychiatryczne oraz neuropsychologiczne, choć nie stanowią objawów osiowych w zespole to opracowywanie procedur medycznych dla tych nieprawidłowości powinno być uwzględnione w optymalnym modelu opieki nad pacjentkami z zespołem Turnera. Przeprowadzenie dalszych prac badawczych i poszerzenie wiedzy w tej dziedzinie może spowodować rozwój metod terapeutycznych, których zastosowanie z pewnością korzystnie wpłynie na codzienne funkcjonowanie chorych i poprawi ich jakość życia.
Clavicular Fractures in the Adolescent
Authors: Patel Midhat , Heyworth Benton E. , Dehghan Niloofar , Mehlman Charles T. , McKee Michael D.
Published: February 2023

➤ Current evidence suggests that the majority of clavicular fractures in adolescents can and should be treated nonoperatively.

➤ Although rare, in certain patients or fracture patterns, nonoperative management may be associated with delayed healing, prolonged disability, and/or poor functional outcome requiring secondary reconstruction.

➤ When warranted, primary open reduction and internal fixation with plate and screw application has consistently good outcomes with a low complication rate, with the most common complication being implant-related symptoms requiring a secondary surgical procedure for implant removal.

➤ Prospective, comparative studies examining operative and nonoperative treatment, including measures of early return to function, injury burden, return to athletic activity, complication and reoperation rates, and shoulder-girdle-specific, long-term outcome measures are warranted to further elucidate which fractures may benefit from primary fixation.
Analysis of Learning Outcomes Module Material for Madrasah Ibtidaiyah Teachers of Teacher Professional Education in Position
Authors: Muthmainnah Fitri , Budiyono Budiyono
Published: February 2023

This study examines the analysis of learning outcomes for the deepening module of Madrasah Ibtidaiyah (Islamic Primary Schools) teachers in teacher professional education in position. The research method used is a qualitative method with a case study approach. The first findings show that the LMS PPG Daljab operational system phase 1 in 2022 has slightly changed or improved from 2021 to 2022. There are several things that must be fulfilled by lecturers and students, namely there are pretests, study contracts, resumes, analysis of teaching materials, analysis material, formative tests, module final tests organized by the center of the matter. Second, there are eight of the thirty Madrasah Ibtidaiyah teachers who must take remedial, seven students repeat the learning and learning theory module with an average value of 66.56 and then two students in the teacher professional development module with an average score of 66.91 and two students in the learning evaluation module with an average score of 60.58. Based on these data, some Madrasah Ibtidaiyah teachers still encounter problems in mastering learning and learning theory, while the ability is one of the important factors in determining learning success.
INCERTIDUMBRE SEXUAL E IMAGEN CORPORAL PERCIBIDA COMO FACTORES PREDICTORES PARA LA DEPENDENCIA DEL CONSUMO DE ALCOHOL EN ESTUDIANTES DE ENFERMERÍA
Authors: Medina-Fernández Josué Arturo , Hernández-Martínez Eva Kerena , Molina Sánchez Janeth Wendoline , Torres-Obregón Reyna , Ruíz-Lara Anahí , Leija-Mendoza Alejandra
Published: February 2023

El consumo excesivo de alcohol puede ser causado por diversos factores, entre ellos los factores psicológicos como la incertidumbre sexual, enfocada a las creencias y valores sexuales. Otro factor es la percepción de imagen corporal, se define como la imagen mental sobre el propio cuerpo. Objetivo. Determinar la influencia de la incertidumbre sexual e imagen corporal sobre la dependencia del consumo de alcohol en estudiantes de enfermería. Método. Estudio predictivo-correlacional, con una muestra de 182 estudiantes recolectado con un muestreo basado en la red por conveniencia. Se aplicó la escala de incertidumbre sexual, el pictograma de Stunkard (imagen corporal) y el instrumento AUDIT (dependencia del consumo de alcohol), se analizó con estadística descriptiva e inferencial mediante SPSS V22. Resultados. Se encontró correlación entre la incertidumbre sexual (r=.152, p=.041) y la imagen corporal (r=.202, p=.006) con el consumo de alcohol. La incertidumbre sexual e imagen corporal percibida influye en un 4.9% de la dependencia del consumo de alcohol, siendo ambos factores predictores (p<.05). Conclusión. La incertidumbre sexual y la imagen corporal predicen el consumo de alcohol en los estudiantes de enfermería, se requiere abordar la medición de otras variables para profundizar los motivos de consumo.
INCREASED VALUE OF SUBSTANCES OR DECREASING ALTERNATIVES? BEHAVIORAL ECONOMICS IN THE TIME OF COVID-19
Authors: González-Roz Alba , Martínez-Loredo Víctor , Secades-Villa Roberto , Coloma-Carmona Ainhoa , Carballo Crespo José Luís
Published: February 2023

COVID-19 offers a chance to test the Reinforcer Pathology (RP) model through the effects of social constraints on the motivation to use drugs. Aims. This study aimed to empirically assess the RP model in the context of a cross-sectional online survey in Spain. Method. During the strictest period of confinement (14th March-12th April 2020), 203 participants provided measures on past 30-day use of legal and illegal substances and responded to hypothetical alcohol and cigarette purchase tasks. Univariate and bivariate analyses were conducted to inform on pre- and intra-pandemic substance use patterns. Breakpoint (i.e., price at which consumption ceases), elasticity (i.e., sensitivity of demand to rises in costs) and intensity (i.e., unrestricted consumption) were used as indicators of substance use demand. Results. Past 30-day alcohol use decreased from 71.4% (145/203) to 50.7% (103/203), tobacco from 14.3% (30/203) to 12.8% (26/203), and cannabis from 8.9% (18/203) to 4.4% (9/203). Predictably, illegal substance use went from 1% (2/203) to 0%. Conclusions. Despite reductions in substance use, alcohol and tobacco reinforcement, as measured by intensity and breakpoint, slightly increased within the first month of confinement. Potentially beneficial nudges and intervention strategies are discussed from the preventive and treatment standpoint.
Consecuencias psicosociales de la regulación del cannabis: un estudio cualitativo
Authors: Molina-Fernández Antonio , Medrano Chapinal Paula , Comellas Sanz Pol
Published: February 2023

Introducción: Las diferentes legalizaciones de uso de cannabis terapéutico y recreativo han intensificado la presencia de este tema en los ámbitos científico, político y social. La regulación del consumo de cannabis recreativo debería tener en cuenta cuáles pueden ser sus consecuencias psicosociales y los enfoques utilizados. El estudio de dichas consecuencias psicosociales es el principal objetivo de esta investigación. Método: Metodología cualitativa: revisión bibliográfica y entrevistas a expertos, con diseño de investigación-acción. Resultados: La regulación debe plantearse desde un enfoque de salud pública y derechos humanos, no desde posturas socioeconómicas o de libertades individuales. Las consecuencias para la población general se integran sobre todo la salud mental y los accidentes, tanto laborales como de tráfico. El principal grupo de riesgo son los jóvenes, especialmente  la combinación de fracaso escolar, dificultades en el ámbito laboral y el descenso del riesgo percibido del consumo de cannabis. La respuesta ante una regulación debe ser proporcional, estructurada y con acciones desde la prevención e intervención temprana. Conclusiones: contemplar el impacto psicológico sobre la salud mental de los consumidores. Se señala el problema que representa la ineficacia de los programas actuales de prevención y tratamiento para los consumidores de cannabis de riesgo.
Factores protectores y conductas sexuales protegidas en estudiantes de secundaria venezolanos
Authors: Guerrero Alcedo Jesús Manuel , Lucena Torrellas Adriana Isabel , Espina Romero Lorena del Carmen
Published: February 2023

Introducción: el comportamiento sexual ha cobrado mayor énfasis entre los profesionales dedicados a la salud, debido a las repercusiones sociales y personales que ha originado en las nuevas generaciones. El mismo se ha convertido en un problema de salud pública a nivel nacional e internacional, el cual incide en una población tan vul­nerable como son los adolescentes. Objetivo: este estudio se propone evaluar empíricamente la influencia directa e indirecta de la edad, el sexo, la autoeficacia para prevenir el VIH, la resiliencia sexual, el bienestar psicológico, el autoconcepto, el apoyo social funcional y la comunicación familiar sobre los comportamientos sexuales protegidos en estudiantes de secundaria venezolanos. Método: comprende un estudio no experimental, correlacional, explica­tivo y con un diseño transversal. Se ha tomado una muestra de 317 estudiantes, seleccionados bajo un muestreo no probabilístico accidental. Resultados: se encontró que los comportamientos sexuales de protección se ven influidos de manera directa por la autoeficacia para la prevención del VIH, la resiliencia sexual y el autoconcepto, e indirecta por el apoyo social funcional, el sexo y la comunicación familiar. Conclusión: Estos hallazgos permitirán diseñar es­trategias de promoción de la salud que fomenten recursos personales que ayudarán a los estudiantes a mantener comportamientos sexuales seguros.
Re-entry Needs Among a Population with Co-occurring Opioid Use and Mental Health Disorders in Massachusetts, USA Jails: Part of a National Plan to Address the Opioid Epidemic
Authors: Posada Rodríguez Camilo , Shaffer Paige M. , Gaba Ayorkor , Drawbridge Dara , Smelson David
Published: February 2023

Introduction. Studies show that the release from jail is a vulnerable transition for individuals with opioid use disorder re-entering their communities. Less is known about individuals with co-occurring mental health and opioid use disorders (COD), particularly their specific needs following release. Objectives. To describe the needs of people with COD within two weeks of release jail. Methods. Baseline data from 155 individuals with COD were collected within two weeks of release from jail across 9 counties in Massachusetts. Univariate analyses were conducted to determine baseline needs. Results. The majority of participants were male (78.7%), White (64.5%), and non-Hispanic (75.5%). The most relevant needs among participants were employment (88.4% were unemployed), opioid overdose prevention (67.7% had at least one non-fatal opioid overdose), mental health symptoms (participants reported anxiety or tension an average of 8.9 days in the past 30 days), and trauma support/treatment (71.6% reported at least one traumatic event in their lifetime). Conclusions. Individuals with COD re-entering their communities have critical needs that must be addressed upon release.
“Sir, you’re hurting me!”: The perspectives of survivors of interpersonal violence and breast cancer
Authors: Simon-Plumb Casey Lu , Hamdan Kate , Fikre Tsion , Singerman Amanda , Bair-Merritt Megan , Rothman Emily F. , Ko Naomi Y.
Published: February 2023

Background
Studies suggest that experiences of interpersonal violence victimization (i.e., partner violence, childhood sexual or physical abuse, and sexual assault) might play a role in breast cancer diagnosis and treatment. To address gaps in knowledge, our study aimed to understand how prior interpersonal trauma affects breast cancer. We conducted 20 semi-structured in-person interviews and asked patients how their interpersonal trauma affected their breast cancer experience and if they had suggestions to improve breast cancer care.
Methods
Patients were recruited through flyers or from providers to whom they had previously disclosed a history of interpersonal violence. One-on-one interviews lasted approximately one hour each. Results were thematically coded in an iterative fashion and analyzed for main themes.
Results
Three themes addressed the relatedness of interpersonal violence and cancer care: 1) perceptions that violence caused the cancer or led to worse outcomes, 2) how breast cancer diagnosis and treatment can trigger interpersonal violence memory (triggers), and 3) difficulty trusting. In addition, three suggestions emerged that related to improving care: the importance of female providers, improved provider communication, and the potential benefits of a buddy system to pair newly diagnosed breast cancer patients with a history of interpersonal violence with breast cancer survivors with a similar background.
Conclusion
Interpersonal violence can influence how women feel about their breast cancer diagnoses, interactions with health care providers, and receiving care for cancer. Improving trauma-informed health care practice would be beneficial for women with breast cancer.
Electronic health records to capture primary outcome measures: two case studies in HIV prevention research
Authors: Dunn David , McCabe Leanne , White Ellen , Delpech Valerie , Kirwan Peter , Khawam Jameel , Croxford Sara , Ward Denise , Brodnicki Elizabeth , Rodger Alison , McCormack Sheena
Published: February 2023

Background

There is increasing interest in the use of electronic health records (EHRs) to improve the efficiency and cost-effectiveness of clinical trials, including the capture of outcome measures.

Main Text

We describe our experience of using EHRs to capture the primary outcome measure – HIV infection or the diagnosis of HIV infection – in two randomised HIV prevention trials conducted in the UK. PROUD was a clinic-based trial evaluating pre-exposure prophylaxis (PrEP), and SELPHI was an internet-based trial evaluating HIV self-testing kits. The EHR was the national database of HIV diagnoses in the UK, curated by the UK Health Security Agency (UKHSA). In PROUD, linkage to the UKHSA database was performed at the end of the trial, and identified five primary outcomes in addition to the 30 outcomes diagnosed by the participating clinics. Linkage also produced an additional 345 person-years follow-up, an increase of 27% over clinic-based follow-up. In SELPHI, new HIV diagnoses were identified either by participant self-report (through internet surveys) or via UKHSA linkage. Rates of survey completion were low, and only 14 of the 33 new diagnoses recorded in the UKHSA database were also self-reported. Thus UKHSA linkage was essential for capturing HIV diagnoses and therefore the successful conduct of the trial.

Conclusions

Our experience of using the UKHSA database of HIV diagnoses as a source of primary outcomes in two randomised trials in HIV prevention was highly favourable, and encourages the use of a similar approach in future trials in this disease area.
Impact of Neurofibromatosis Type 1 on Quality of Life Using the Skindex-29 Questionnaire Quality of Life in Nf1
Authors: Rivera Ana M. Cieza , Fuertes Carlos Lobato , Fernández-Villa Tania , Martín Vicente , Atallah Isis
Published: February 2023

Background: Neurofibromatosis type 1 (NF1) is the most common genodermatose which predisposed affected patients to melanic lesions and benign tumors. NF1 is associated with considerable esthetic and functional burden affecting negatively patients’ quality of life (QoL). This study aims to assess the clinical features of NF1 patients and evaluate their impact on QoL. NF1 patients were identified from a public health database of a region in Spain. All patients underwent clinical and ophthalmological evaluation for NF1 features. QoL was measured with the Spanish version of the Skindex-29. Logistic regression was performed to determine the factors associated with quality of life.
Results: Fourty patients fulfilling NF1 National Institute of Health criteria were recruited (40.95 years ± 16.1 SD). The mean total Skindex-29 score was 14 ± 11 (emotion: 20 ±18, symptoms 10±11, functioning 9±10).Woman, NF1 patients with lower educational level or macrocephaly were associated with poorer quality of life scores. Itching, headaches and sleep troubles were identified to negatively influence quality of life of NF1 patients.
Conclusion: NF1 considerably influences the psychological well-being of NF1 patients. We observed that female patients, low-educated patients and macrocephalic patients scored higher on the emotional dimension of the skindex-29 and could therefore be more at risk of depression. We also pointed out some “minor symptoms” that negatively impacts NF1 patients QoL such as itching, sleep troubles or headache which could be treated if seek by doctors.
Synthetic Aperture Sensing for Occlusion Removal with Drone Swarms
Authors: Nathan Rakesh John Amala Arokia , Kurmi Indrajit , Bimber Oliver
Published: February 2023

We demonstrate how efficient autonomous drone swarms can be in detecting and tracking occluded targets in densely forested areas, such as lost people during search and rescue missions. Exploration and optimization of local viewing conditions, such as occlusion density and target view obliqueness, provide much faster and much more reliable results than previous, blind sampling strategies that are based on pre-defined waypoints. An adapted real-time particle swarm optimization and a new objective function are presented that are able to deal with dynamic and highly random through-foliage conditions. Synthetic aperture sensing is our fundamental sampling principle, and drone swarms are employed to approximate the optical signals of extremely wide and adaptable airborne lenses.
Janus Porous Polylactic Acid Membranes with Versatile Metal-Phenolic Interface for Biomimetic Periodontal Bone Regeneration
Authors: Li Jianhua , Ge Shaohua , Zhang Yaping , Chen Yi , Ding Tian , Zhang Yandi , Yang Daiwei , Zhao Yajun , Liu Jin , Ma Baojin , Bianco Alberto
Published: February 2023

Conventional treatment to periodontal and many other bone defects requires the use of barrier membranes to guided tissue regeneration (GTR) and guided bone regeneration (GBR). However, current barrier membranes normally lack of the ability to actively regulate the bone repairing process. Herein, we proposed a biomimetic bone tissue engineering strategy enabled by a new type of Janus porous polylactic acid membrane (PLAM), which was fabricated by combining unidirectional evaporation-induced pore formation with subsequent self-assembly of a bioactive metal-phenolic network (MPN) nanointerface. The prepared PLAM-MPN simultaneously possesses barrier function on the dense side and bone-forming function on the porous side. In vitro, the presence of MPN nanointerface potently alleviated the proinflammatory polarization of rat bone marrow-derived macrophages (BMDMs), induced angiogenesis of human umbilical vein endothelial cells (HUVECs), and enhanced the attachment, migration and osteogenic differentiation of periodontal ligament stem cells (PDLSCs). The implantation of PLAM-MPN into rat periodontal bone defects remarkably enhanced bone regeneration. This bioactive MPN nanointerface within a Janus porous membrane possesses versatile capacities to regulate cell physiology favoring bone regeneration, demonstrating great potential as GTR and GBR membranes for clinical applications.
Performance analysis of vacation interruption queue with balking and reneging
Authors: Majid Shakir , Vijaya Laxmi Pikkala , Angelika Bouchentouf Amina , M Aijaz
Published: February 2023

This paper presents a comprehensive study of an infinite buffer M/M/1 queue with variant working vacations subjected to Bernoulli schedule vacation interruption wherein the customers balk with a probability. The server commences a working vacation as soon as the system becomes empty and resumes a regular busy period by interrupting the working vacation with probability 1 − p if the system is non-empty at a service completion instant or continues the vacation with probability p. The customers may renege due to slow service rate during the working vacation. The inter-arrival times, service times (both during regular busy period and working vacation periods), vacation times and reneging times are mutually independent and exponentially distributed. We derive the probability generating function of the steady-state probabilities and obtain the closed form expressions of the system size for different server states. Various performance measures and the monotonicity on some performance measures with respect to K are discussed, and a cost optimization problem through quadratic fit search method has been considered. The stochastic decomposition structures of the mean queue length and mean waiting time are verified.
Mathematics Subject Classification (2000) 60K25 · 68M20 · 90B22
A Practical Approach for Employing Tensor Train Decomposition in Edge Devices
Authors: Kokhazadeh Milad , Keramidas Georgios , Kelefouras Vasilios , Stamoulis Iakovos
Published: February 2023

Deep Neural Networks (DNN) have made significant advances in various fields including speech recognition and image processing. Typically, modern DNNs are both compute and memory intensive, therefore their deployment in low-end devices is a challenging task. A well-known technique to address this problem is Low-Rank Factorization (LRF), where a weight tensor is approximated by one or more lower-rank tensors, reducing both the memory size and the number of executed tensor operations.
However, the employment of LRF is a multi-parametric optimization process involving a huge design space where different design points represent different solutions trading-off the number of FLOPs, the memory size, and the prediction accuracy of the DNN models. As a result, extracting an efficient solution is a complex and time-consuming process. In this work a new methodology is presented that formulates the LRF problem as a (FLOPs vs. memory vs. prediction accuracy) Design Space Exploration (DSE) problem. Then, the DSE space is drastically pruned by removing inefficient solutions. Our experimental results prove that the design space can be efficiently pruned, therefore extract only a limited set of solutions with improved accuracy, memory, and FLOPs compared to the original (non-factorized) model. Our methodology has been developed as a stand-alone, parameterized module integrated into T3F library of TensorFlow 2.X.
WITHDRAWN: Non-interference patterns evolving to orthogonal interference patterns in same wave experiment
Authors: Peng Hui
Published: February 2023

Young’s double slit experiments revived the wave theory of light. The interpretation is that light behaves as waves before and after passing through the double slit. In this article, we study the evolution of the patterns of the wave experiments. The experiments show the novel universal phenomena: (1) Within a certain macroscopic distance from the diaphragm, light behaves as photons and produces a non-interference pattern; while near the screen, the photons produce an interference pattern; namely the nature and characteristics of the patterns are distance-dependent; (2) The non-interference patterns evolves to the orthogonal interference patterns gradually in the same wave experiment; (3) The convex lens stops the evolution of the patterns at the position where it is placed. We suggest that a complete theory should be able to interpret the non-interference pattern, the interference pattern, and the evolution from one pattern to another.
Vaccine Promotion Strategies in Community Pharmacy Addressing Vulnerable Populations: a Scoping Review
Authors: Chadi Alexandre , Thirion Daniel J. G. , David Pierre-Marie
Published: February 2023

Context: Social determinants of health drivers of vaccine inequity and leading to higher risks of complication from infectious diseases in under vaccinated communities. In many countries, pharmacists have gained the rights to prescribe and administer vaccines, which contributes in improve vaccination rates. Little is however known on how they define and target vulnerable communities. Objective: The purpose of this study is to describe how vulnerable communities are targeted in community pharmacies. Methods: We performed a systematic search of the Embase and Medline database in August 2021 inspired by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocols (PRISMA ScR). Articles in English, French or Spanish addressing any vaccine in a community pharmacy context and that target a population defined as vulnerable were screened for inclusion. Results: A total of 1039 articles were identified through the initial search and 63 articles met the inclusion criteria. The vast majority of the literature originated from the North America (n = 54, 86%) and was addressed influenza vaccination (n = 29, 46%), pneumonia (n = 14, 22%), herpes zoster (n = 14, 22%) or human papilloma virus (n = 14, 22%). Lifecycle vulnerabilities (n = 48, 76%) such as age and pregnancy were most often used to target vulnerable patients followed by clinical factors (n = 18, 29%), socio-economical determinants (n = 16, 25%) and geographical vulnerabilities (n = 7, 11%). The most frequently listed strategy was providing a strong recommendation for vaccination, promotional posters in pharmacy, distributing leaflet/bag stuffers and providing staff training. A total of 24 barriers and 25 facilitators were identified. The main barriers associated to each vulnerable category were associated to effective promotional strategies to overcome them. Conclusion: Pharmacists prioritize lifecycle and clinical vulnerability at the expense of narrowing down the definition of vulnerability. Some vulnerable groups are also under targeted in pharmacies. A wide variety of promotional strategies are available to pharmacies in order to overcome the specific barriers experienced by various groups.
The emergence of socioeconomic inequalities in smoking during adolescence and early adulthood
Authors: Alves Joana , Perelman Julian , Ramos Elisabete , Kunst Anton E
Published: February 2023

Background

While it is known that educational inequalities in smoking start during early and middle adolescence, it is unknown how they further develop until adulthood. The aim of this article is to map, in the Portuguese context, how educational inequalities in smoking emerge from pre-adolescence until young adulthood.

Methods

This study used longitudinal data from the EPITeen Cohort, which recruited adolescents enrolled in schools in Porto, Portugal. We included the 1,038 participants followed at ages 13 (2003/2004), 17, 21, and 24 years. We computed the odds ratio (OR) for the prevalence of smoking states (never smoking, experimenter, less-than-daily, daily and former smoker) and the incidence of transitions between these states, as function of age and education, stratified by sex. We also added interaction terms between age and education.

Results

Educational inequalities in daily smoking prevalence, with higher prevalence among those with lower educational level, emerged at 17 years old and persisted until higher ages. They were formed in a cumulative way by the increased risk of experimenting between 13 and 17 years, and increased risk of becoming daily smoker between 17 and 21 years. The incidence of smoking cessation was higher among the higher educated. Inequalities were formed similarly for women and men, but with lower level and showed no significance among women.

Conclusions

These results highlight that actions to prevent smoking should also take in account the potential impact in smoking inequalities, and should focus not only on middle adolescence but also on late adolescence and early adulthood.