bluuebunny/crossref_metadata_2025 huggingface dataset:
CAPM Intertemporal: um teste empírico utilizando dados brasileiros
Authors: Machado Octavio Portolano , Bortoluzzo Adriana Bruscato , Martins Sérgio Ricardo , Sanvicente Antonio Zoratto
Published: October 2019

O artigo examina a validade empírica do Inter-temporal Capital Asset Pricing Model (ICAPM) com o uso de dados do mercado brasileiro. É empregada a metodologia de Bali e Engle (2010), com a estimação de covariâncias condicionais entre retornos de carteiras de ações e fatores de precificação. As covariâncias são a seguir utilizadas como variáveis explicativas na equação de precificação. Os resultados confirmam o modelo para o período de 1988 a 2012. O coeficiente de aversão a risco é positivo e significante, e os fatores relevantes são taxas de juros e de inflação, além do preço do ouro. O oposto ocorre com a taxa de câmbio. A quebra do período de estudo em subperíodos indica que eventos importantes, como mudanças de regime econômico e a crise de 2008 têm o poder de modificar as associações encontradas e enfraquecer a validade do modelo.
Os efeitos da introdução de agentes de liquidez no mercado acionário brasileiro
Authors: Perlin Marcelo
Published: October 2019

O objetivo principal deste artigo é analisar empiricamente o efeito da introdução de formadores de mercado no processo de compra e venda de ações no mercado acionário brasileiro. Agregando informações sobre as datas de início de contrato de formadores de mercado a uma privilegiada base de dados de alta frequência, foi possível efetivar um estudo de evento para verificar os efeitos da introdução dos agentes de liquidez. Conforme esperado, observou-se que o formador de mercado aumentou significativamente a liquidez dos papéis. Foi possível verificar um aumento médio de 31% no número de negócios entre o período anterior e posterior ao início das atividades do formador de mercado. Reporta-se também que a entrada do agente de liquidez muda significativamente a autocorrelação dos sinais de transação em aproximadamente 10%, sendo este resultado mais forte para as ações menos líquidas. Além disso, a pesquisa também indica resultados heterogêneos para a performance do formador de mercado quando os mesmos são segmentados pela instituição financeira de origem. Tal informação pode servir de base para uma escolha inteligente do formador de mercado por parte das empresas negociadas em bolsa.
A Volatilidade do Fluxo de Capital para Economias Emergentes
Authors: Rocha Katia , Moreira Ajax
Published: October 2019

O artigo propõe um modelo de painel para os determinantes da volatilidade do fluxo de capital para um grupo de 18 economias emergentes no período de 2000-2011. Avaliamos a robustez do modelo em relação a diferentes medidas de volatilidade e a vários tipos de fluxo de entrada de capital; e enfatizamos o papel do desenvolvimento do sistema financeiro doméstico e da qualidade institucional do governo. Os emergentes analisados representavam em Janeiro de 2013 aproximadamente 95% do índice EMBIG, além de constituírem as maiores economias emergente para destino do fluxo de capital internacional segundo relatório do Banco de Compensações Internacionais - BIS (2009). Os principais resultados sugerem uma redução da volatilidade do fluxo de capital mediante adoção de políticas voltadas para melhorias na qualidade institucional do governo e que promovam o desenvolvimento, estabilidade e eficiência do sistema financeiro doméstico.
Exposição a Risco e Captação em Fundos de Investimento: os Cotistas Monitoram a Alocação de Ativos?
Authors: Schiozer Rafael Felipe , Tejerina Diego Lins de Albuquerque Pennachi
Published: October 2019

Esse estudo identifica o impacto do risco dos ativos dos fundos de renda fixa e referenciados sobre sua captação no mercado brasileiro, explorando a variação exógena na percepção de risco de passivos emitidos por bancos (CDBs), causada pela crise financeira internacional que se seguiu à quebra do banco Lehman Brothers nos EUA, em setembro de 2008. A hipótese central é que a exposição dos fundos a ativos negativamente impactados pela crise afete negativamente sua captação. Dentre os fundos não-exclusivos, encontrou-se que a proporção de ativos mais afetados pela crise impactou negativamente a captação, o que indica que os cotistas monitoram a alocação de ativos e exercem um poder disciplinador sobre a gestão por meio de saque de seus recursos. Nos fundos exclusivos, em que se supõe que o cotista tenha maior poder de influenciar na realocação de ativos, não se identifica relação significativa entre exposição a ativos afetados pela crise e captação.
Lista de Avaliadores - 2013
Authors: Leal Ricardo Pereira Câmara
Published: October 2019

Cinquenta e três indivíduos avaliaram artigos em 2013, dos quais nove trabalham em universidades estrangeiras. De acordo com a política da RBFin, cada avaliador deve realizar apenas uma avaliação por ano, com a exceção de avaliações subsequentes do mesmo artigo. Em 2013, foram feitos 79 convites para avaliar, uma média de 2,3 convites para cada um dos 35 artigos admitidos para avaliação. Destes, 50 pessoas aceitaram o convite (63%) mas 3 não entregaram o parecer prometido, 7 apresentaram uma justificativa para não aceitar e 22 não responderam ao convite (28%).
Index Tracking com Controle do Número de Ativos
Authors: Sant'Anna Leonardo Riegel , Filomena Tiago Pascoal , Borenstein Denis
Published: October 2019

Index tracking é uma estratégia de investimento passiva, com objetivo de formar portfólios para reprodução do desempenho de um índice do mercado. Esse artigo apresenta uma proposta de modelagem de otimização de index tracking com controle do número de ativos na carteira, correspondente à restrição de custos de transação. O modelo é aplicado ao Ibovespa entre Jan/2009 e Jul/2012. Foram formadas carteiras sem limite de ativos e com limite de 40, 30 e 20 ativos, com rebalanceamento em 20, 40 e 60 períodos. Os resultados evidenciam a composição de carteiras estatisticamente significativas para acompanhar a rentabilidade do índice, especialmente para rebalanceamento de 60 períodos, com custos de transação mais baixos devido ao maior intervalo de rebalanceamento. Verificou-se também que alterações de parâmetros do solver Cplex não influenciaram os resultados, especialmente para tempo de solução. Assim, concluímos sobre a necessidade de aplicar métodos heurísticos para formação de carteiras com menos ativos.
Eficiência da Carteira de Mercado no Plano Média-Variância
Authors: Noda Rafael Falcão , Martelanc Roy , Securato José Roberto
Published: October 2019

Este estudo procura responder à crítica de inconsistência do CAPM baseada na alegação de que a carteira de mercado não está sobre a fronteira eficiente. Para tanto, faz-se uma otimização numérica, utilizando-se dados de ações brasileiras entre 2003 e 2012. Obtêm-se retornos e desvios padrão ajustados tais que (i) a fronteira eficiente passe pela carteira de mercado e (ii) sejam minimizadas as distâncias entre retornos e desvios padrão amostrais e ajustados. Da mesma forma que Levy & Roll (2010) encontraram para o mercado dos EUA, conclui-se que os ajustes necessários não são significativos, tanto para retornos quanto para desvios padrão. O resultado sugere que possíveis imprecisões do CAPM decorrem principalmente de erros de estimativa dos parâmetros utilizados, e não de inconsistência do modelo, e que outros fatores explicativos dos retornos podem ser pouco relevantes. Em decorrência, o resultado refuta a mencionada alegação de inconsistência do CAPM no Brasil.
Geração de Cenários de Estresse para Curva de Juros
Authors: Dario Alan De Genaro , Fernández Mariela
Published: October 2019

Este trabalho descreve uma aplicação da classe de

modelos Heath-Jarrow-Morton na geração de cenários de estresse para a estrutura a termo da taxa de juros. Por meio da análise de componentes principais consegue-se reduzir a dimensão do problema e criar uma ponte entre a informação que um especialista possui para definir cenários, informação geralmente de dimensão baixa, e a robustez do modelo Heath-Jarrow-Morton. A metodologia é aplicada ao mercado brasileiro no auge da crise em 2008 e em outras oportunidades.
Modelando Contágio Financeiro através de Copulas
Authors: Valls Pereira Pedro Luiz , De Souza Santos Ricardo Pires
Published: October 2019

O presente artigo tem por objetivo testar a hipótese de contágio entre os índices dos mercados financeiros dos Estados Unidos, Brasil, Japão e Inglaterra para o período de 2000 a 2009. Cópulas variantes no tempo foram usadas para captar o impacto da crise do Subprime na dependência entre mercados. O modelo implementado foi um modelo ARMA(1,0) st-GARCH(1,2) para as distribuições marginais e cópulas Normal e Joe-Clayton (SJC) para a distribuição conjunta. Os resultados obtidos permitem concluir que tanto para a cópula gaussiana quanto para a cópula SJC há evidências de contágio entre o mercado americano e o mercado brasileiro. Para os outros dois mercados, londrino e japonês, as evidências da presença de contágio entre estes mercados e o americano não mostraram-se suficientemente claras em ambas as cópula
Reservas de Óleo e Gás em Modelos de Avaliação para Empresas Petrolíferas
Authors: Ribeiro Eduardo Pontual , Menezes Neto Luiz Teles , Bröker Bone Rosemarie
Published: October 2019

O objetivo deste artigo é avaliar o efeito da acumulação de reservas de petróleo e gás sobre o valor de mercado de empresas integradas do setor petrolífero. A análise baseia-se no modelo de Ohlson, que possui como casos especiais os múltiplos P/L (preço/lucro), P/E (preç patrimônio líquido) e, para o caso da indústria petrolífera, o múltiplo P/R (preço- reservas). Reservas são importantes para petrolíferas, mas não aparecem no patrimônio líquido (PL), nas práticas contábeis geralmente aceitas. Baseado em dados de empresas listadas na NYMEX, os resultados mostram que as reservas correlacionam-se positivamente com o preço de mercado das empresas. Todavia, o mercado parece penalizar uma estratégia de aumento de reservas sem contrapartida de aumento de lucros ou PL, com redução esperada no preço das ações. Por fim, o uso de múltiplos pode ser considerado ineficiente para a avaliação deste tipo de empresa, pois a relação entre lucros ou PL e preço da ação não parece proporcional.
Efeitos da Estabilização de Preços sobre os Retornos de Curto Prazo dos IPOs
Authors: Pinheiro Douglas Beserra , Carvalho Antonio Gledson de
Published: October 2019

Durante a estabilização de preços em IPOs, o underwriter recompra parte da emissão (ASC do inglês aftermarket short covering), motivando duas suposições sobre o propósito da mesma: manter o preço artificialmente alto para favorecer clientelas específicas ou ludibriar investidores e evitar a flutuação de preço decorrentes do fluxo inicial de informação e da ação de flippers. Nossa análise indica que no período pós estabilização os retornos dos IPOs estabilizados são inferiores aos dos não-estabilizados; quanto maior a intensidade da estabilização, menores são retornos pós-estabilização; IPOs cuja sobrealocação é inteiramente coberta pelo ASC apresentam retornos inferiores aos não-estabilizados, o que não ocorre naqueles em que o ASC é parcial. Assim, as duas suposições são parcialmente certas: em alguns casos a estabilização é usada para manter o preço em um patamar sustentável e em outros é usada para manter o preço em nível artificial.
Previsibilidade de Retornos e Eficiência no Mercado Acionário Brasileiro
Authors: Ely Regis Augusto
Published: October 2019

Este artigo procura evidências de previsibilidade no mercado acionário brasileiro usando portfólios agrupados por setores e tamanho das firmas com dados de 1999 a 2008. É conduzido um teste de razão de variância automático usando wild bootstrap que elimina a escolha arbitrária dos valores de truncagem e melhora as propriedades de amostra finita. Os resultados sugerem que (i) ações de empresas do setor industrial são altamente previsíveis, (ii) ações de empresas menores são mais previsíveis do que de empresas maiores, (iii) o mercado acionário brasileiro, mensurado através do índice Ibovespa de 1986 a 2008, mostrou um aumento de eficiência desde 1994.
Case Report: Renal impairment and bilateral cataracts in a patient with Maffucci syndrome
Authors: Nawaz Abid , Iqbal Aqsa , Shaukat Nauman , Khan Muhammad Aslam , Farukhuddin FNU , Kumar Anil A. , Kumar Vinesh
Published: October 2019

Maffucci syndrome is a sporadic, non-hereditary condition that is characterized by the presence of multiple skeletal and vascular lesions. We present the case of a 37-year-old man who complained of multiple swellings on the hands, face and wrists affecting the quality of his life. Bilateral cataract and renal impairment were two other features identified in our patient. Renal impairment was likely due to renal vascular malformation, as all other causes of renal compromise were ruled out. Radiographic images showed multiple radiolucent areas in both hands. Multiple enchondromas with pathologic confirmation of skin lesions as cavernous haemangiomas confirmed the diagnosis of Maffucci syndrome in our patient. The patient was referred to the orthopaedic department for osteotomy. Currently, the patient is on dialysis and no other complications have been observed in follow-up visits. This is the first report of Maffucci syndrome which discusses renal involvement. Regular screening of renal functions in patients with Maffucci syndrome could prevent renal complications.
Can Brands Circumvent Marketing Regulations? Exploiting Umbrella Branding in Financial Markets
Authors: Lu Yan , Mitra Debanjan , Musto David , Ray Sugata
Published: October 2019

Hedge funds benefited from their umbrella brand mutual fund affiliate’s advertising and exploited this effect to circumvent a marketing ban.
One Step at a Time: Does Gradualism Build Coordination?
Authors: Ye Maoliang , Zheng Jie , Nikolov Plamen , Asher Sam
Published: October 2019

This study investigates a potential mechanism to promote coordination. With theoretical guidance using a belief-based learning model, we conduct a multiperiod, binary-choice, and weakest-link laboratory coordination experiment to study the effect of gradualism—increasing the required levels (stakes) of contributions slowly over time rather than requiring a high level of contribution immediately—on group coordination performance. We randomly assign subjects to three treatments: starting and continuing at a high stake, starting at a low stake but jumping to a high stake after a few periods, and starting at a low stake while gradually increasing the stakes over time (the Gradualism treatment). We find that relative to the other two treatments, groups coordinate most successfully at high stakes in the Gradualism treatment. We also find evidence that supports the belief-based learning model. These findings point to a simple mechanism for promoting successful voluntary coordination.

This paper was accepted by Axel Ockenfels, behavioral analysis.
Committed Diversification: Why Authenticity Insulates Against Penalties for Diversification
Authors: Hahl Oliver , Ha Jaekyung
Published: October 2019

Work in organization theory has highlighted that diversification triggers concerns over the newly diversified firm’s capability or commitment to serve its audience. Although this work has shown that perceived lack of commitment may be an important problem for diversifying firms, it has not been established what might resolve these commitment concerns and reduce demand-side penalties for diversifying to serve new customers. We argue that a firm’s ability to signal authenticity will increase perceptions of commitment and resolve ambiguities about commitment generated by diversification. We use a multimethod approach including qualitative evidence from a case in the behavioral health industry and experimental methods to isolate these observed effects. In a qualitative study, we examine a case in which two firms saw divergent outcomes when they tried to engage in the exact same diversification activity and show that when a firm signals that they are highly authentic (i.e., when stakeholders perceive the firm to be willing to fulfill commitments even while sacrificing short-term rewards), diversification does not threaten perceived commitment. However, those who cannot signal authenticity are less likely to be selected in the market because diversification is seen as a threat to perceived commitment. We then test these findings in two experiments using the primary customer audience, addiction recovery therapists, as participants. In a final experiment, we test some key boundary conditions of our argument, finding support in the context of markets for car mechanics, which suggests that our argument may be applicable more broadly than healthcare into markets for various types of credence goods.
‘We are just obsessed with risk’: healthcare providers' views on choice of place of birth for women
Authors: McCauley Hannah , McCauley Mary , Paul Gillian , van den Broek Nynke
Published: October 2019

Women make choices throughout pregnancy and childbirth and interactions with healthcare providers are integral to the journey. Healthcare providers have the potential to advise, influence and support women in their choices as to where to give birth. The aim of this study was to examine Northern Ireland healthcare providers' attitudes and experiences of women choosing place of birth, independent of risk profile. A qualitative study design was used to undertake key informant interviews with healthcare providers who were involved in caring for women antenatally, intrapartum and postnatally. Seven midwives and five obstetricians were interviewed. These interviews were transcribed, coded and presented in themes. Emerging themes included: informed decision-making among pregnant women; understanding and judgement of risk; autonomy and choice; culture of control and fear; and human rights. Interviewees highlighted barriers to women being able to access their chosen place of birth because of legal concerns, cultural perception of birth, and lack of senior managerial support for those providing clinical care to women who are considered at risk of complications during pregnancy or birth. Proposed solutions include developing a human rights-based approach which is about health and not isolated pathologies and focuses on empowering women, and not merely avoiding maternal morbidity or mortality.
Perinatal mental ill health: the experiences of women from ethnic minority groups
Authors: Watson Helen , Soltani Hora
Published: October 2019

Objectives

This study aimed to investigate ethnic minority women's experiences and opinions of perinatal mental health problems and the provision support services.

Methods

An exploratory survey was undertaken using a questionnaire. Quantitative data were analysed using descriptive statistics and a simple thematic analysis was used for the qualitative data. A total of 51 responses from women of 14 different ethnic minority backgrounds were analysed.

Findings

Women from minority ethnic groups face barriers to seeking help for perinatal mental ill health as a result of ongoing stigma, the poor attitudes and behaviours of health professionals and inappropriately designed services.

Conclusions

Future interventions should focus on providing adequate cultural competency for health professionals and ensure that all women are able to access culturally appropriate spaces to talk and be listened to in community settings and wider services.
The legacy of Thatcherism in European labour relations: the impact of the politics of neo-liberalism and austerity on collective bargaining in a fragmenting Europe
Authors: Lucio Miguel Martínez , Koukiadaki Aristea , Tavora Isabel
Published: October 2019

The ongoing popularity of neo-liberalist ideologies and the impact of state-imposed austerity measures has been having a detrimental impact on the structure of industrial relations within the European Union (EU), especially in the periphery of Europe. This report assesses these developments in the EU member states most affected by the most recent economic crisis, namely Greece, Ireland, Italy, Portugal, Romania, Slovenia and Spain. We highlight how trade unions in the countries assessed are increasingly constrained in their ability to regulate the conditions of work through collective agreements, which have systematically deteriorated, making it difficult to sustain mobilisation and negotiation strategies. This has had a deleterious effect on pay and working time. Broader austerity measures have also had a substantial impact on areas such as labour inspection, judicial processes and state mediation services, leading to heightened disorganisation of labour relations with negative effects for both workers and management. The impact of neo-liberal and anti-trade union ideas initially inspired by the New Right in the United Kingdom and the United States of America during the 1980s has played a significant role in shaping the ideology behind this shift in EU policy towards ‘weaker states’. We therefore argue that this political heritage of disorganising labour relations carries great risks in social and organisational terms for all actors concerned, especially workers and their representatives. To this end, we develop the critique of deregulation outlined in Ewing et al (2016) and argue that coordinated structures are important for questions of social justice.
Double-J stents forgotten for four years: a case report
Authors: Prihadi Johannes Cansius , Kusumajaya Christopher
Published: October 2019

Placement of double-J ureteral stents after endourologic procedures and some open urological surgeries are practical and safe. However, when neglected in situ, undesired problems may occur, leading to serious medical and legal issues. Complications from ureteral stents with protracted indwelling durations include urosepsis, renal failure, encrustation, and spontaneous fractures which may be retained or voided in the urine (stenturia). We report a 40-year-old woman of forgotten double-J ureteral stents, inserted 4 years prior to this study during a gynecologic operation. The patient had pulled out the double-J stents from her urethra herself and presented with impending sepsis. Then, she underwent ureterorenoscopic lithotripsy, but it failed to remove the remaining encrusted double-J stent. As a result, percutaneous nephrolithotomy was performed successfully and she had symptom-free thereafter.
Discovering Cross-Reactivity in Urine Drug Screening Immunoassays through Large-Scale Analysis of Electronic Health Records
Authors: Hughey Jacob J , Colby Jennifer M
Published: October 2019

BACKGROUND

Exposure to drugs of abuse is frequently assessed using urine drug screening (UDS) immunoassays. Although fast and relatively inexpensive, UDS assays often cross-react with unrelated compounds, which can lead to false-positive results and impair patient care. The current process of identifying cross-reactivity relies largely on case reports, making it sporadic and inefficient, and rendering knowledge of cross-reactivity incomplete. Here, we present a systematic approach to discover cross-reactive substances using data from electronic health records (EHRs).

METHODS

Using our institution's EHR data, we assembled a data set of 698651 UDS results across 10 assays and linked each UDS result to the corresponding individual's previous medication exposures. We hypothesized that exposure to a cross-reactive ingredient would increase the odds of a false-positive screen. For 2201 assay–ingredient pairs, we quantified potential cross-reactivity as an odds ratio from logistic regression. We then evaluated cross-reactivity experimentally by spiking the ingredient or its metabolite into drug-free urine and testing the spiked samples on each assay.

RESULTS

Our approach recovered multiple known cross-reactivities. After accounting for concurrent exposures to multiple ingredients, we selected 18 compounds (13 parent drugs and 5 metabolites) to evaluate experimentally. We validated 12 of 13 tested assay–ingredient pairs expected to show cross-reactivity by our analysis, discovering previously unknown cross-reactivities affecting assays for amphetamines, buprenorphine, cannabinoids, and methadone.

CONCLUSIONS

Our findings can help laboratorians and providers interpret presumptive positive UDS results. Our data-driven approach can serve as a model for high-throughput discovery of substances that interfere with laboratory tests.
OS CLÁSSICOS DA SOCIOLOGIA E NÓS: REFLEXÃO SOBRE TRÊS LIVROS PARADIDÁTICOS
Authors: Shiota Ricardo Ramos
Published: October 2019

Os clássicos da sociologia variam conforme cada país, eles são os autores que gozam de status superior, artífices de práticas exemplares de pesquisa, que levantaram problemas e propuseram soluções teóricas que ainda elucidam aspectos das sociedades contemporâneas. Karl Marx, Émile Durkheim e Max Weber se tornaram clássicos no Brasil, entre outras coisas, devido ao esforço de Florestan Fernandes na década de 1950, quando sistematizou a contribuição de cada um desses autores para uma teoria da investigação sociológica. A recepção desses clássicos no país não perdeu de vista os problemas da sociedade brasileira, que tradicionalmente esteve voltada para explicar o país. Por isso, determinadas leituras foram rotinizadas, criando versões próprias desses autores clássicos. Dessa perspectiva, esse texto faz uma reflexão sobre três livros paradidáticos da coleção “pontos de referência” da Editora Vozes, escritos por especialistas franceses: A sociologia de Marx, de Jean-Pierre Durand; A sociologia de Durkheim, de Philippe Steiner; e A sociologia de Weber, de Catherine Colliot- Thélène.
Endogenous secretion of insulin and its relationship with immunogenetic markers in infants with insulin-dependent diabetes mellitus
Authors: Osokina I. V. , Scherbacheva L. N. , Lebedev N. B. , Belovalova I. M. , Knyazeva A. P. , Yazdovsky V. V. , Dedov I. I.
Published: October 2019

The level of C-peptide is a marker determining the clinical course of insulin-dependent diabetes mellitus (IDDM). The factors influencing the volume of residual endogenous secretion of insulin in IDDM patients are not yet well known. In order to elucidate the effect of HLA-phenotype on the residual function .of pancreatic beta-cells and the course of diabetes, 114 children, 55 boys and 59 girls aged 8 months to 6.5 years, suffering from IDDM, were examined. HLA phenotype was detected by the standard microlymphocytotoxic test. Fifty-nine HLA antigens of classes I and II, locuses A, B, DR, DQ were taken into consideration. Basal and radial C-peptide was assessed by radioimmunoassay. The pancreatic insulin-secretory function was found reduced in young patients with IDDM. The mean values of C- peptide were 0.13 ± 0.01 nmol/liter. Residual secretion of insulin was revealed in 56.2% of children. HLA markers of high risk of IDDM development in the first yeais of life were revealed: DQw3. DR3/4. DR4, DR3, B8 antigens. The markers of high risk of diabetes DR3 and DR4, and moreover, DR3/4. as well as the age by the disease onset and duration of IDDM were found to influence the size and duration of functioning of beta-cells.
Clinicobiochemical correlations in patients with the predominance of high-molecular prolactin in the blood serum
Authors: Makarovskaya Ye. Ye. , Ilovaiskaya I. A. , Martynov A. V. , Marova Ye. I. , Melnichenko G. A. , Bulatov A. A.
Published: October 2019

A new rapid method for assesment of the ratio of immunoreactive prolactin forms with high and low molecular mass has been developed, which permits screening of large groups of patients. It was used in examinations of 44 women with hyperprolactinemea of various origin and with normoprolactinemic galactorrhea. High-molecular immunoreactive prolactin predominated in the blood serum of 25% of patients. This predominance did not depend on the origin of hyperprolactinemia, clinical picture of the disease, or level of total immunoreactive prolactin in the blood. Heterogenous clinical symptoms of the disease were characteristic of these patients: a typical symptom complex was absent in moderate hyperprolactinemia, whereas in patients with manifest hyperprolactinemia of a tumorous origin a classical clinical picture of persistent galactorrhea-amenorrhea was observed. A follow-up showed the predominance of high-molecular prolactin irrespective of the changes in the level of total immunoreactive prolactin in the blood, disease course, onset of pregnancy and labor.
Present-day methods of therapy of pituitary adenomas
Authors: Serpuhovitin S. Yu. , Kirpatovskaya L. Ye. , Komolov I. S.
Published: October 2019

Pituitary tumors often called adenomas, mainly come from the anterior pituitary and in about 90% of cases secrete large quantities of one or more pituitary hormones, which leads to changes in homeostasis and the occurence of specific endocrine diseases such as acromegaly, a lactorrhea-amenorrhea syndrome, a Cushing's disease, etc. The clinical picture of both hormone-secreting and non-secreting pituitary tumors can also be caused by their germination of their interconnected structure of the pituitary gland, parasellar areas with impaired brain function.

The etiology of pituitary tumors is still unknown. This is largely due to the difficulties in choosing a method of treatment of a tumor. Although most pituitary adenomas are benign and relatively slow-growing formations, it should be remembered that about 50% of tumors can grow quite quickly, penetrating through the Dura mater into the parasellar region. Quite rarely, pituitary tumors are malignant. In this case, they metastasize to the subarachnoid space, brain and other organs.

The emergence of new methods of topical diagnosis and biochemical studies makes it possible to verify the presence of pituitary tumors at the stages of microadenoma.'This, in turn, allows for a more effective impact on them until the patient is completely cured, including the termination of hypersection, restoration of pituitary function and prevention of relapse of the disease. The main methods of treatment of pituitary adenomas are medication, radiation therapy, adenomectomy, as well as their combined use.
Effect of repeated stress exposures on body sensitivity to glucocorticoids and insulin
Authors: Tseilikman V. Ye. , Volchegorsky I. A. , Kolesnikov O. L. , Vyazovsky I. A. , Ghiyenko I. A. , Kolesnikova A. A. , Afanasyev O. A. , Lifshits R. I.
Published: October 2019

Effects of repeated stress exposures on the sensitivity to exogenous glucocorticoids and insulin were studied. The reaction to glucocorticoids was assessed by the sensitivity of lymphoid organs and peripheral blood in response to administration of a synthetic long-acting glucocorticoid analog kenalog. Insulin sensitivity was assessed from the latency of development of insulin coma. Repeated stress exposures were found to appreciably limit the changes in the thymus and spleen caused by exogenous glucocorticoids. This permitted a conclusion about the capacity of repeated stress exposures to reduce the sensitivity of an organism to the effects of exogenous glucocorticoids. Moreover, these exposures reduced the latency of insulin coma development, this indicating an increased insulin sensitivity of the body. Combination of repeated stress exposures with drug blocking of adrenoreceptors with obsidan in a dose of 0.05 mg per animal increased the latency of insulin coma development.
In memory of Professor V. M. Dilman
Authors: Problems of endocrinology Editorial team of
Published: October 2019

On May 21, 1994, at the 69th year of his life, the famous Russian scientist professor Vladimir Mikhailovich Dilman died. V. M. Dilman made a significant contribution to the development of various fields of medical science and created a number of new scientific directions. Among the most important of them are the development of a model of the menopause mechanism (together with V. G. Baranov in 1949), the idea of the primary role of changing the sensitivity threshold of the hypothalamus in the mechanism of aging and age-related pathology (1958), the creation of a large number anagormones (1961 and subsequent years). V. M. Dilman formulated a fundamentally new model of the development of diseases, according to which age-related pathology is the result of the transformation of the development mechanism of the body into the mechanism of aging and the emergence of certain diseases (including, in particular, type II diabetes mellitus). V. M. Dilman is the author of 13 monographs and more than 400 journal articles. He is the founder of a large school, and his students and followers continue to work in the directions created by Vladimir Mikhailovich.
The process of repair of trophic ulcers in patients with diabetes
Authors: Myskina N. A. , Tokmakova A. Yu. , Antsiferov M. B.
Published: October 2019

In the last 30 years, there has been a sharp increase in the incidence of diabetes mellitus (DM), especially in industrialized countries, and its prevalence tends to further increase [3]. The main cause of disability and death of patients are late complications of this disease. Among them, it is especially important to identify developing diabetic foot syndrome (DFS), which is defined as infection, ulcer and / or destruction of deep tissues, associated with neurological disorders and decreased main blood flow in the arteries of the lower extremities of varying degrees severity (International Diabetic Foot Agreement, Netherlands, 1999)
The internal picture of the disease in type 1 diabetes
Authors: Sidorov P. I. , Novikova I. A. , Solov'ev A. G. , Mul'kova N. N.
Published: October 2019

То study the internal picture of the disease, 73 patients with type 1 diabetes mellitus (DM) were examined. Among them, there were 43 females and 31 males whose age was 14 to 60 years and whose disease duration was 6 months to 39years. Psychological diagnostic tests evaluating their attitude to the disease revealed that in the patients, hypo- and hypernosognosias were prevalent in the pattern of nosognosias, hyponosognosias being observed somewhat more frequently, and adequate reactions to the disease were observed rel­atively rarely (15%). Among hyponosognosias, there was most commonly an ergopathic or anosognosic type of an attitude to the disease, which leads to the underestimation of their disease and to poor metabolic control. Hypemosognosia was more characteristic for females, which in the presence of severe complications and with a long-term history of the diseases is a consequence of DM complications and premorbid personality traits. A sensitive type as a result of social disadaptation and discrimination of society towards DM patients holds a central position in the pattern of hypernosognosias.

Obligatory psychological and psychotherapeutic correction of the internal picture of disease in DM is required to achieve good pa­rameters of metabolic control and qualitative management of DM, which will promote the patients’ better life quality.
Clinical and morphological features of reparative processes in patients with the diabetic foot syndrome
Authors: Udovichenko. О. V. , Tokmakova A. . Yu. , Antsiferov M. B. , Yushkov P. V. , Dedov I. I.
Published: October 2019

The purpose of the study was to examine structural abnormalities in the skin and granulation tissue, which explain long-term heal­ing and recurrent trophic ulcers in patients with the neuropathic diabetic foot syndrome who received adequate treatment. Biopsy specimens were taken from the granulation tissue and skin of the edge of a trophic ulcer in 12 patients (mean age 48.4+6.6 years) with types 1 and 2 diabetes mellitus (its duration was 14.0+4. 7 years). All the patients were treated for the neuropathic diabetic foot syndrome according to the generally accepted recommenda­tions. According to the duration of trophic ulcer, the patients were divided into 2 groups: 1) 4 patients with a history of under 3 months and 2) 8 patients with a history of above 3 months. Ac­cording to the presence or absence of trophic ulcers in the history, all the patients were again divided into Groups A (recurrent ul­cers, n = 5) and В (primary ulcers, n = 7). Patients with slowly healing ulcers were found to have an abnormal foot pressure more frequently, as evidenced by computerized pedography (the peak load in the ulcer area being in 63% of them versus 25% in Group 1) and some specific features of granulation tissue (excess of active fibroblasts, immaturity of the extracellular matrix, at­rophy and sclerosis of nerve fibers). Patients with recurrent ulcers were older, demonstrated lower vibration perception scores, mor­phological features, such as abundant active polymorphonuclear leukocytes, mast cells with signs of degranulation and T-helper cells, immature extracellular matrix, fibrinoid necrosis and young capillary vessels with microthrombi. Thus, the detection of the above granulation tissue and wound edge changes (especially with an abnormal foot pressure pattern, significantly low vibra­tion perception scale, and old age) makes it possible to suggest slow healing or recurrence of ulcer.
Social and psychological aspects of life quality of diabetics
Authors: Sidorov P. I. , Solovyov A. G. , Novikova I. A.
Published: October 2019

In order to evaluate the inner picture of the disease and the changes in socio-psychological sphere under the effect of endocrinological disease, 120 diabetics were interviewed using a special questionnaire including 85 questions on different aspects of patient’s life. The results showed pronounced emotional and personal problems in all socially significant spheres, which deteriorated the quality of life. A distorted picture of the disease with fixation on "escape into disease" was characteristic of the majority of respondents. The detection of patient’s emotions concerning their suffering and revelation of the inner picture of disease in diabetics are aimed at evaluation of the adaptive potential, value motivation system, and defense mechanisms for development of more adequate psychotherapeutic approaches.
Qual é o lugar da Base?
Authors: Zanardi Teodoro Adriano Costa
Published: October 2019

Este trabalho pretende trazer como a lógica do capital se faz presente sem qualquer pudor no período vivido pós-golpe de 2016, tendo a Base Nacional Comum Curricular como pano de fundo de políticas públicas educacionais que se propõem a intensificar às desigualdades responsabilizando escolas públicas, professores/as e estudantes pela (má) qualidade da educação brasileira. Através de referências comprometidas com o desvelamento da desigualdade, inerente ao capitalismo e fundados na tese marxiana contra Feuerbach, adotamos a teoria crítica como fundamento não só para interpretar o contexto atual, mas, também, para colaborar com ações que potencializem o papel de transformação social da educação inspirado especialmente em Paulo Freire. Problematizar a proposta de Base Nacional Comum Curricular, sua concepção curricular e como o/a professor/a comprometido com a emancipação e transformação social é, portanto, o objetivo desse ensaio que deseja colocar esse documento em seu lugar quando falamos de Educação para a transformação social.
Review on medicinal importance of Vigna genus
Authors: Pandey Sonali
Published: October 2019

Globally, there are more than 500,000 plant species (green scum, duckweed, lichens, liverworts, fungi, ferns, conifers, mosses and flowering plants etc.) that maintain earth’s environmental equilibrium, ecosystem stability and also possess vast endemic, aesthetic and cultural importance, provide medicine, food, fuel, shelter and clothing. Plants are used as therapeutic agents to improve health by a large part of population. Several clinical facts suggest that plant derived foods hold various potential health benefits and well known as neutraceuticals. These are the products that are used as food or as a part of food (foodstuffs), able to cure and prevent diseases in addition to their basic nutritional value. More than 200,000 chemical compounds are synthesized by plants and no doubt, also possess medicinal importance. Worldwide, about 70% plant based preparations are used as traditional medicines and also facilitate the base for 50 percent of prescription and/or over the counter drugs used in the Western-type practice of medicine. For underdeveloped and developing countries, it is a need to provide safe, efficient and cheap medications. In various part of India medicinal plants are widely distributed and always have increasing demand due to their medicinal properties. The present review is focused on the genus Vigna which is widely cultivated and used as neutraceuticals. They grow in varied climatic zones, in high temperatures, low rainfall and poor soils with low input in form of fertiliser and irrigation that make them valuable crop plants. As Vigna is an important genus that fulfils the food demand, useful in cosmetics and medicines, there is scope to enhance its productivity via resource conservation, optimum use of rainwater, bridging the yield gaps and innovations in technology transfer and up scaling. One of the important steps to find out a way to increase the production is the detection and analysis of naturally occurring DNA sequence variation by using DNA markers or molecular markers as these markers are indispensable tool that construct maps of genetic linkage and mark the agronomically important traits.
Wybrane współczesne nurty polskiej myśli politycznej, red. J. Kornaś, R. Lisiakiewicz, Wydawnictwo Adam Marszałek, Toruń 2016, ss. 328.
Authors: Bojarowicz Tomasz
Published: October 2019

Recenzja
New Determinants of Political Socialization in the Internet Age
Authors: Pawełczyk Piotr , Jakubowski Jakub
Published: October 2019

W procesie socjalizacji politycznej media wydają się odgrywać coraz istotniejszą rolę. Wynika to nie tylko z dużej ilości czasu spędzanego każdego dnia przed ekranami i innymi nośnikami informacji, ale i coraz większej „intymności” w relacjach z urządzeniami – większość Polaków (ok. 64% w 2017 r. w grupie 15+) posiada smartfon, który daje możliwości bycia online niemalże w każdym momencie życia. Należy założyć, iż w grupie młodzieży szkolnej, odsetek ten jest większy. Skłania to do zadania pytania: na ile dostęp do sieci wpływa na proces socjalizacji politycznej i jakie są jego skutki w obszarze procesów społecznego dostosowania? Celem artykułu jest ich zestawienie i próba zrewidowania założeń teoretycznych dotyczących pojęcia socjalizacji politycznej. Poddajemy w wątpliwość aktualność pewnych założeń ery przedinternetowej w stosunku do współczesnych realiów świata funkcjonującego w trybie permanent-logged-in. Wysuwamy też propozycję kilku rekomendacji mogących stanowić podstawę do bardziej użytecznego społecznie wykorzystania mediów w obszarze dostosowania się (w szczególności młodej) jednostki do życia w warunkach demokracji medialnej.
On Nodal Solutions of the Nonlinear Choquard Equation
Authors: Gui Changfeng , Guo Hui
Published: October 2019

This paper deals with the general Choquard equation

-

Δ
⁢
u

+

V
⁢

(

|
x
|

)

⁢
u

=

(

I
α

*

|
u
|

p

)

⁢

|
u
|

p
-
2

⁢
u

 

in 
⁢

ℝ
N

,

-\Delta u+V(|x|)u=(I_{\alpha}*|u|^{p})|u|^{p-2}u\quad\text{in }\mathbb{R}^{N},

where

V
∈

C
⁢

(

[
0
,
∞
)

,

ℝ
+

)

{V\in C([0,\infty),\mathbb{R}^{+})}

is bounded below by a positive constant, and

I
α

{I_{\alpha}}

denotes the Riesz potential of order

α
∈

(
0
,
N
)

{\alpha\in(0,N)}

. In view of the convolution term, the nonlocal property makes the variational functional completely different from the one for local pure power-type nonlinearity. By combining the Brouwer degree and developing some new techniques, a family of radial solutions with a prescribed number of zeros is constructed for

p
∈

[
2
,

N
+
α

N
-
2

)

{p\in[2,\frac{N+\alpha}{N-2})}

, while the degeneracy happens for

p
∈

(

N
+
α

N

,
2
)

{p\in(\frac{N+\alpha}{N},2)}

. This result complements and improves the ones in the literature in the aspect of the range of p.
Distributed trajectory planning for multi-agent discrete event systems
Authors: Appel Marcus , Walther Michael , Konigorski Ulrich
Published: October 2019

Many systems like manufacturing systems, biological processes and even stock markets can be seen as networks of coupled decision makers and thus be described as networked discrete event systems (DES) or multi-agent discrete event systems (MADES). Information interchange between agents is usually performed indirectly via competition for shared resources. The problem of trajectory planning for MADES is about finding an optimal sequence of decisions for the particular agents. The planning process can be performed in a distributed manner. To encode the trajectory planning problem, we utilize Petri net models and present a formal way to derive integer linear programs (ILPs) that exhibit a bordered block-diagonal structure. We apply Dantzig’s decomposition method to decompose the LP-relaxed problem into multiple subproblems that can be solved locally by their corresponding agents. In general, the obtained LP solutions are non-integer. Therefore, we ensure feasibility to the original ILP using a superior Branch-and-Bound algorithm. Hence, we end up with a so called Branch-and-Price algorithm, tailored to solve trajectory planning problems for general MADES via distributed optimization.
System Co-Design (SCODE): Methodik zur Analyse hybrider Systeme
Authors: Bitzer Matthias , Herrmann Martin , Mayer-John Eckart
Published: October 2019

Die zunehmende Komplexität von regelungstechnischer Funktionalität und deren Umsetzung in Software erfordert eine Systematik zur Integration von systemtheoretischen als auch softwaretechnischen Vorgehensweisen. Die vorgestellte SCODE-Methode zielt auf eine systematische Herleitung von Betriebsmodi und Verifikation aller für den Funktionsentwurf relevanten logischen Zusammenhänge im Sinne einer „Essentiellen Analyse“ für mechatronische Systeme. Der Nutzen einer systematischen modularen Strukturierung ist neben garantierter (logischer) Vollständigkeit und Konsistenz durch eine damit einhergehende Komplexitätsreduktion sowie bessere Wartbarkeit und Testbarkeit gegeben. Der Artikel beschreibt die Methode anhand eines mechatronischen Beispiels, zeigt ihren Nutzen auf und stellt die vorhandene Toolunterstützung vor.
PI-Zustandsregler - eine methodische Neubetrachtung
Authors: Grabmair Gernot , Gahleitner Reinhard
Published: October 2019

Dieser Beitrag diskutiert die Wahlmöglichkeiten hinsichtlich der konstanten Führungsgrößenaufschaltung, um einen bestehenden Zustandsregler für allgemeine d. h. auch sprungfähige sowohl zeitkontinuierliche als auch zeitdiskrete LTI-SISO-Systeme um einen Integralanteil auf einen sogenannten PI-Zustandsregler zu erweitern. Der Fokus dieser Arbeit liegt in einer systemanalytischen Interpretation der charakteristischen Fälle. Infolge des konstruktiven Zugangs können Methoden präsentiert werden, wie ein bestehender Zustandsregler ohne vollständigen Neuentwurf um einen Integralanteil erweitert werden kann. Dies ermöglicht prinzipiell eine ressourcenschonende online Umparametrierung bzw. Zu- und Abschaltung des I-Anteils. Von besonderem Interesse ist dabei die Möglichkeit, durch dezidierte Wahl der Vorfilterkonstante sogar die Invarianz des gesamten Führungsverhaltens des ursprünglichen Zustandsreglers zu erzielen. Dies wird durch systematische Abspaltung eines nicht erreichbaren Teilsystems erzwungen. Weiters wird hierfür die direkte Äquivalenz zu einem reduzierten Störgrößenbeobachter gezeigt. Eine andere Parametrierung erlaubt, rampenförmigen Führungssignalen asymptotisch exakt zu folgen bzw. derartige Ausgangsstörungen zu unterdrücken. Die Demonstration der wesentlichen präsentierten Methoden an einem Simulationsmodell mit integrierendem Verhalten schließt diesen Beitrag.