bluuebunny/crossref_metadata_2025 huggingface dataset:
THE CULTURAL SIGNIFICANCE AND ISLAMIC VALUES OF GUGON TUHON
Authors: Kurwidaria Favorita , Rahadini Astiana Ajeng , Purnama SF. Lukfianka Sanjaya , Setyawan Bagus Wahyu
Published: November 2020

This research focused on studying gugon tuhon in Surakarta and its relation to Islamic values. The gugon tuhon was related to the marriage cycle, pregnancy cycle, and children family education. The data were obtained through interviewing the Javanese society in Surakarta area. It employed an interactive analysis with the cultural interpretation relevant to Islamic values. The result indicates that some gugon tuhon in the marriage include prohibition for brides to go out by themselves and conduct wedding ceremonies in Sura/Muharram month. In the pregnancy cycle of gugon tuhon, pregnant women are prohibited from gossip and think negatively since those result in the child personality. Husbands of pregnant women are also prohibited from killing or hurt animals because their children will be harmed. The gugon tuhon in educating children includes the prohibition to go out at Maghrib (sunset prayer) because an evil spirit will kidnap them and suggest washing hands and legs before visiting babies. The existence of gugon tuhon can be used as the character education to construct good habits. Besides, gugon tuhon functions to implant Islamic moral values in terms of tolerance, responsibility, and good deeds to build a harmonious life system.Penelitian ini mengkaji gugon tuhon di Surakarta dan kaitannya dengan nilainilai keislaman. Gugon tuhon yang dikaji adalah dalam siklus pernikahan, siklus kehamilan, dan yang digunakan untuk mendidik anak. Data diperoleh dari hasil wawancara dengan masyarakat di wilayah karesidenan Surakarta. Analisis interaktif digunakan dengan pemaknaan secara kultural selanjutnya direlevansikan dengan nilai islami. Hasil penelitian menunjukkan beberapa gugon tuhon dalam perkawinan, diantaranya adalah larangan calon penganten putri untuk bepergian sendiri dan larangan untuk melaksanakan pernikahan di bulan Sura/Muharram. Dalam gugon tuhon siklus kehamilan, wanita hamil dilarang menggunjing dan berpikiran negatif karena akan berdampak pada watak anaknya. Suami yang istrinya sedang hamil juga dilarang membunuh dan menyakiti hewan karena anaknya akan celaka. Gugon tuhon dalam mendidik anak seperti larangan untuk keluar di waktu Magrib karena akan diculik oleh wewe gombel dan anjuran untuk membasuh kaki-tangan sebelum bertemu dengan bayi. Adanya gugon tuhon dapat digunakan sebagai sarana pendidikan karakter kepada generasi muda untuk membentuk kebiasaan-kebiasaan yang baik. Selain itu, fungsi gugon tuhon juga sebagai sarana menanamkan nilai-nilai moral keislaman seperti tenggang rasa, toleransi, tanggung jawab, dan selalu berbuat baik kepada sesama untuk membentuk sistem kehidupan masyarakat yang harmonis.
Producción de biocombustibles y empleo rural en Colombia 2009-2015
Authors: Barrientos Marin Jorge , Vasco Correa Carlos Andrés
Published: November 2020

Este trabajo de investigación estima el efecto de la política de mezcla de biocombustibles sobre la generación de empleo rural en Colombia, a través de la aplicación de la metodología empírica basada en vectores autorregresivos (VAR), para estimar la elasticidad del nivel de empleo y simular su comportamiento cuando la producción y los precios de biocombustibles o combustibles fósiles sufren variaciones. Se construye una base de datos que contiene nivel de producción, precios y empleo con periodicidad mensual entre 2009 y 2015 en Colombia. Se estudia la estructura empírica subyacente y la manera como se puede estimar la elasticidad en modelos vectoriales, finalmente se analiza la política de promoción de los biocombustibles y sus efectos sobre la generación de empleo. Las correlaciones dinámicas estimadas muestran que no existe un efecto apreciable sobre el nivel de empleo cuando hay variaciones en los niveles de producción y precios de los biocombustibles.
Retention strength of ball-attachment titanium post for removable partial denture or overdenture
Authors: Melilli Dario , Wandscher Vinícius Felipe , Ciocca Leonardo , Currò Giuseppe , Parisi Candida , Gallina Giuseppe , Baldissara Paolo
Published: November 2020

Aim: To evaluate the retention of an endodontic titanium postwith a spherical head for removable partial denture or overdentureattachment according to surface treatment type. Methods: Sixtyhealthy single-rooted teeth, sectioned at the enamel/cementumjunction, were treated endodontically and steadily fixed in theembedding acrylic resin. The titanium posts were subdivided intofour groups: control, no surface treatment (Ctrl); posts with macroretentivegrooves (MR); air abrasion of the post surface (AB); andposts with macro-retentive grooves and air abrasion of the postsurface (MR+AB). The posts were luted in the root canal usingself-adhesive dual resin cement. Pull-out testing was performedusing a universal testing machine until complete detachment wasachieved. After pull-out testing, the metallic posts were examinedunder an optical microscope and the failures were classifiedbased on the cement distribution pattern on the extracted posts:0, no cement left on the post (cement/post failure); 1, postsurface partially covered by adhered cement (post/cement anddentin/cement mixed failure); 2, post surface completely coveredby cement (dentin/cement failure). The retention data wereanalyzed by one-way ANOVA, Bonferroni–Dunn test (p<0.05)and Weibull analysis. Results: AB showed the highest retentionvalue (485.37±68.36), followed by MR+AB (355.80±118.47), MR(224.63±42.54) and Ctrl (113.12 ± 51.32). AB and MR showedthe highest Weibull moduli. Conclusions: The data indicatedthat air abrasion alone could significantly increase the retentionof titanium posts/attachments for use with overdentures orremovable partial denture.
Revealing offering culture suguh sesajen
Authors: Ghozuan Anxy Yudhatama
Published: November 2020

In this modern era, we can get everything we want easily. Human most likely to use technology and think rationally. However, the people in Semen, Tanggalrejo Village, Mojoagung District, Jombang Regency is different because they still believe in the existence of supernatural things and routinely perform offerings activity called “suguh sesajen” to the Tomb of Bariden great grandfather and Mah great grandfather which are believed to be able to obtain good fortune and perform several rituals. This research uses qualitative methods by conducting in-depth interviews and observations. The results of this study indicate that the community still adheres to the tradition “suguh sesajen” offerings and believes in the myth of the occult power of the tomb.
Consumption patterns of boarding students
Authors: Lubiyansyah Rahmandhita Aulia
Published: November 2020

Boarding house students are students who migrate. Their consumption patterns are determined by the income they receive each month. The consumption of boarding students, among others, is for food consumption and nonfood consumption. This study aims to analyze the consumption patterns of boarding house students from the class of 2017 in the Department of Anthropology, Airlangga University. The data of this study were obtained from the questionnaire (primary) and interviews with boarding house students from the class of 2017 in the Department of Anthropology, Airlangga University. The results of this study showed that the high income students tend to be more consumptive compared to the lower income ones.
Music: entertainment media with millions of benefits for physical performance
Authors: Nasrullah Mochamad Ferdyan
Published: November 2020

We cannot deny that besides having a function as an entertainment, music also has influences to its listeners. Music existence has been there and developed since thousands years ago, and in every development, Music can perform beautiful tones and meaningful messages for its listeners. Music can take the listeners to their world that will give significant influences in their lives. Music can influence the minds and brains; therefore, it can produce health by listening music. This research aims to find out the influence that we can get from listening to music, digging the information related to the benefits of music, and analyzing how music influences its listeners. The method used in this research is the quantitative approach by using the survey and questionnaire methods. The conclusion that the researcher can explain in this research is that music is not only entertainment media but music can also send the listeners’ tiredness away; furthermore music brings the positive effects to its listeners. The effects that the listeners often feel are: that music can influence someone’s cognitive development which covers someone’s intelligence level until someone’s memory and also someone’s health that can reduce the blood pressure, reduce the anxiety levels, stress and depression.
Tanggung Gugat Badan Pengawas Obat dan Makanan Terhadap Peredaran Ranitidine
Authors: Rufaidah Ani
Published: November 2020

Ranitidine pertama kali di legalkan di Indonesia pada tahun 1989, ranitidine merupakan suatu senyawa yang digunakan sebagai bahan paduan untuk menjadi obat. Fungsi ranitidine digunakan untuk menyembuhkan tukak lambung, gerd, dan maagh. Namun pada september 2019 FDA dan EMA menginformasikan bahwa didalam ranitidine terdapat kandungan cemaran NDMA (nitrosodymethylamine) yang justru dapat menimbulkan bahaya terbentuknya kanker sehingga beberapa izin edar ranitidine dicabut bahkan dimusnahkan karena kandungan NDMA (nitrosodymethylamine) melebihi ambang batas yang ditetapkan yakni 96 ng/hari. Dari hasil peringatan tersebut, diketahui bahwa BPOM tidak menjalankan kewenangan dalam mengawasi peredaran obat setelah beredarnya suatu produk (post-market) sebagaimana mestinya karena hal tersebut baru diketahui setelah 30 tahun ranitidine beredar dipasaran.
Wewenang Hakim Menilai Sendiri Kerugian Negara Dalam Mengadili Tindak Pidana Korupsi
Authors: Kusuma Dimas Prasanto
Published: November 2020

Kewenangan menilai dan menghitung kerugian negara berdasarkan Pasal 32 Undang-Undang Nomor 31 Tahun 1999 juncto Undang-Undang Nomor 20 Tahun 2001 menimbulkan permasalahan dalam persidangan karena hanya instansi yang berwenang untuk menghitung kerugian negara, hal ini tentunya menimbulkan pertanyaan tentang apakah hakim sebagai wakil tuhan didunia untuk menegakan keadilan dapat menunjukan sisi kemerdekaan hakim dalam memutus perkara. Hakim dalam mengadili perkara tindak pidana korupsi memperoleh kewenangan menilai sendiri kerugian negara berdasarkan fakta persidangan sesuai dengan Pasal 6 surat edaran mahkamah agung Nomor 4 Tahun 2016. Tidak terikatnya hakim dengan hasil instansi yang berwenang terhadap hasil audit kerugian negara hal ini menujukan sisi kemerdekaan hakim berdasarkan Pasal 1 angka 1 Undang-Undang Nomor 48 Tahun 2009.
Ketidaksesuaian Ketentuan Jaminan Sosial Dalam Undang-Undang Nomor 24 Tahun 2011 dan Peraturan Pemerintah Nomor 70 Tahun 2015
Authors: Arighi Hafidh
Published: November 2020

Dibentuknya Peraturan Pemerintah Nomor 70 Tahun 2015 Tentang Jaminan Kecelakaan Kerja dan Jaminan Kematian bagi Aparatur Sipil Negara menimbulkan kontroversi Pada Pasal 7 Peraturan Pemerintah Nomor 70 Tahun 2015 Tentang Jaminan Kecelakaan Kerja dan Jaminan Kematian Bagi Aparatur Sipil Negara menyebutkan bahwa jaminan kecelakaan kerja dan jaminan kematian bagi Aparatur Sipil Negara dikelola oleh PT TASPEN dan oleh sebab itu bertentangan dengan ketentuan yang ada dalam Undang-Undang Nomor 40 Tahun 2004 Tentang SJSN, Undang-Undang Nomor 24 Tahun 2011 Tentang BPJS dan juga Peraturan Presiden Nomor 109 Tahun 2013 Tentang Penahapan Kepesertaan Program Jaminan Sosial. Hasil dari penelitian ini menurut Putusan Mahkamah Agung Nomor 32 P/HUM/2016 dan Putusan Mahkamah Konstitusi Nomor 98/PUU-XV/2017 yang menyatakan bahwa Peraturan Pemerintah Nomorr 70 Tahun 2015 Tentang Jaminan Kecelakaan Kerja dan Jaminan Kematian bagi Aparatur Sipil Negara tidak bertentangan dengan Undang-Undang Nomor 40 Tahun 2004 Tentang SJSN, Undang-Undang Nomor 24 Tahun 2011 Tentang BPJS dan juga Peraturan Presiden Nomor 109 Tahun 2013 Tentang Penahapan Kepesertaan Program Jaminan Sosial.
Kewajiban Pengusaha Menyediakan Ruang dan Waktu Laktasi Bagi Pekerja Wanita Menyusui
Authors: Marpaung Timothy Ronald
Published: November 2020

Hak buruh perempuan untuk menyusui pada waktu kerja adalah bagian dari hak reproduksi wanita. Perlindungan hak buruh khususnya buruh perempuan telah banyak diatur dalam berbagai peraturan perundang-undangan di Indonesia, namun pada praktiknya pemenuhan hak terhadap buruh perempuan masih belum maksimal. Perjanjian Kerja Bersama dalam hal ini menjadi payung hukum yang kuat bagi pemenuhan hak tersebut. Mengenai hak untuk menyusui pada waktu kerja, perselisihan yang dapat terjadi adalah perselisihan hak dan perselisihan kepentingan. Perselisihan hak terjadi apabila hak buruh untuk menyusui tersebut tidak dicantumkan dalam perjanjian Kerja Bersama, sebaliknya perselisihan kepentingan terjadi apabila hak buruh untuk menyusui tersebut sudah dicantumkan dalam Perjanjian Kerja Bersama tetapi tidak dipenuhi. Maka dari itu, diperlukan kesadaran dari buruh dan juga pengusaha untuk pemenuhan hak menyusui sesuai dengan yang telah diatur dengan peraturan perundang-undangan yang berlaku.
DIFFERENCES OF BONE REGENERATION USING BOVINE HYDROXYAPATITE AND BOVINE HYDROXYAPATITE WITH FREEZE-DRIED PLATELET RICH PLASMA ALLOGRAFT IN BONE DEFECT OF FEMORAL WHITE RABBIT
Authors: Edward Mouli , Dominica Henry , Mahyudin Ferdiansyah , Rantam Fedik Abdul
Published: November 2020

Background: Bone defects to date have been a significant problem in the Orthopedics field. Hydroxyapatite is a bone graft that is often chosen if it has osteoconductive properties. Platelet-rich plasma (PRP) has a higher platelet concentration than the concentration in normal blood, capable of providing many bioactive molecules in physiological proportions. Hydroxyapatite given freeze-dried PRP is expected to create a graft that can strengthen the matrix while promoting osteoinduction.Methods: This study compares the effects of regeneration on the bone between bovine hydroxyapatite (BHA) and bovine hydroxyapatite with freeze-dried platelet-rich plasma (FD-PRP) as a bone graft in bone defect of the femoral white rabbit. The 12 equal New Zealand white rabbits aged 6-9 months are divided into two groups. Bone defects were made in the lower femoral meta-diaphysis with a diameter of 2.5 mm. The defects were filled with BHA with FD-PRP allograft in the treatment group and BHA in the control group. Both groups will be sacrificed in the third and sixth weeks, then evaluated histologically for microvascular structure, osteoblasts, woven bone, type-I collagen, osteocalcin, alkaline phosphatase, and immunoglobulin G.Results: During the evaluation in week 3 and 6, microvascular structure, osteoblast, and type-I collagen decreased in both groups with insignificant differences (p>0.05). Woven bone, osteocalcin, and immunoglobulin G increased in the treatment group but was not significant (p>0.05). Alkaline phosphatase increased higher in the treatment group, with a considerable difference in the sixth week (p=0.008).Conclusion: The elevation in the production of woven bone, osteocalcin, and alkaline phosphatase at the third and sixth-week evaluations highlight the possibility that administering BHA given FD-PRP may have contributed to the healing of bone defects.
Recent advancements in understanding the terroir effect on aromas in grapes and wines
Authors: Van Leeuwen Cornelis , Barbe Jean-Christophe , Darriet Philippe , Geffroy Olivier , Gomès Eric , Guillaumie Sabine , Helwi Pierre , Laboyrie Justine , Lytra Georgia , Le Menn Nicolas , Marchand Stéphanie , Picard Magali , Pons Alexandre , Schüttler Armin , Thibon Cécile
Published: November 2020

Terroir is about the link between wine and its origin. It has long been understood by sensory evaluation that the taste of wine from a given variety can be related to its origins. Specific organoleptic characteristics of wine are influenced by environmental factors such as soil and climate. By deconstructing the effect of measurable soil and climate parameters on grape and wine aroma compounds, the terroir effect on wine typicity can be better understood. Climate influences on vine development and grape ripening are mainly associated with temperature, radiation and rainfall, while soil influences are primarily associated with water availability and nitrogen supply. Significant advances have been made over recent years in understanding wine aromas and their molecular basis and influences of climate and soil on a wide range of molecules responsible for wine aroma expression. This article aims to review these recent research advances to obtain a more comprehensive understanding of how terroir influences wine typicity. The effect of terroir on wine quality and typicity is sometimes considered intangible and difficult to explain on a scientific basis. By combining agronomic, analytical and sensory approaches, however, this review shows that the terroir effect is mediated by measurable factors that can easily be monitored in the vineyard. Assessment of the results compiled by this review allows the suggestion that terroir expression at specific sites might be maximized by choosing appropriate plant material in relation to soil and climate, by acting on manageable parameters like vine water and nitrogen status, or by implementing canopy management to modify microclimate in the bunch zone.
Prognostic Value of the Six-Minute Walk Test in Heart Failure
Authors: Astolpho Vinicius , Barbosa Roberto , Devens Gabriela , Louzada Leticia , Lima Pietro , Sylvestre Rodolfo , Serpa Renato , Calil Osmar , Barbosa Luiz Fernando
Published: November 2020

Background: The 6-minute walk test (6MWT) is a simple and low-cost method that allows assessment of functional capacity in patients with heart failure (HF). However, the prognostic role of 6MWT in HF remains uncertain. Objectives: We aimed to evaluate the 6MWT as a predictor of mid-term adverse outcomes in patients with HF with mid-range and reduced ejection fraction. Methods: Prospective single-center cohort study that included patients with HF with an ejection fraction under 50% at a specialized outpatient HF service. Patients underwent the 6MWT on admission and were compared according to the distance walked: Group I walked ≥350 meters and group II <350 meters. The primary outcome was a composite of death from any cause or hospitalization for HF decompensation in one-year follow-up. Secondary outcomes were the components of the primary outcome in an isolated analysis. Results: Sixty patients were included, 43.3% male, with a mean age of 61.1 ± 12.9 years and ejection fraction 34.3 ± 10.1%. 52 patients (86.7%) were on guideline-directed triple therapy for HF. The average distance walked in the 6MWT was 395.1 ± 98.8 meters, with 40 patients (66.7%) in group I and 20 (33.3%) in group II. The primary outcome in groups I and II were, respectively, 15,0% and 35,0% (p=0.05). One-year mortality was 5.0% vs 15.0% (p=0.18) and the hospitalization rate was 10.0% vs 20.0% (p=0.28). Conclusions: There was no association of distance <350 meters in the 6MWT with the primary outcome in patients with HF. Despite the higher occurrence of outcomes in group II, the difference was not statistically significant in this analysis. On a selective basis, the 6MWT may be a useful tool for prognostic stratification in HF, if combined with other methods.
Issues and Challenges Confronting the Achievement of Zero Plastic Waste in Victoria, Australia
Authors: Ng A. W. M. , Ly Srenghang , Muttil Nitin , Nguyen Cuong
Published: November 2020

Despite the increase in popularity of Zero Waste (ZW) concept, the successful implementation of this concept in waste management is still facing many challenges. The plastic recycling rate in Australia is currently only about 9.4%, which could leave up to 90.6% of plastic consumption being sent to landfills. The state of Victoria (in Australia) has proposed an ambitious plan to upgrade its waste and recycling system and to divert about 80% of waste from landfills by 2030. The aim of this research is to study Victoria’s current waste management plan and to develop a simulation model to assess the feasibility of it achieving zero plastic waste by 2035. In this direction, a fundamental knowledge of global ZW implementation needs to be acquired in order to understand the challenges, obstacles, and uncertainties in achieving ZW target. A simulation model is established using a method called double baselines. This method was developed as an improvisation to address the limitation of data availability for the model development. The model will run on 4 scenarios including one from Victoria’s current plan. Outcomes from the model are produced in comparative charts covering 6 key considerations including the rates of plastic consumption, waste to landfill, diversion, recycling, relative accumulative cost and effort. The findings of this study pointed out that Victoria’s current plan are feasible for its goal and presented with opportunities for improvement especially towards zero plastic waste. Besides, study results also reveal that the Victoria’s current plan to achieve 80% diversion rate by 2030 is possible but the zero plastic waste target by 2035 is less likely to happen.
On the Generalization Ability of Data-Driven Models in the Problem of Total Cloud Cover Retrieval
Authors: Krinitskiy Mikhail , Aleksandrova Marina , Verezemskaya Polina , Gulev Sergey , Sinitsyn Alexey , Kovaleva Nadezhda , Gavrikov Alexander
Published: November 2020

Total cloud cover (TCC) retrieval from ground-based optical imagery is a problem being tackled by a few generations of researchers. The number of human-designed algorithms for the estimation of TCC grows every year. However, there is not very much progress in terms of quality, mostly due to the lack of systematic approach to the design of the algorithms, to the assessment of their generalization ability, and to the assessment of the TCC retrieval quality. In this study, we discuss the optimization nature of data-driven schemes for TCC retrieval. In order to compare the algorithms, we propose the framework for the assessment of the algorithms characteristics. We present several new algorithms that are based on deep learning techniques: a model for outliers filtering, and a few models for TCC retrieval from all-sky imagery. For training and assessment of data-driven algorithms of this study, we present the Dataset of All-Sky Imagery over the Ocean (DASIO) containing over one million of all-sky optical images of visible sky dome taken in various regions of the World Ocean. The research campaigns contributed to DASIO collection took place in the Atlantic ocean, the Indian ocean the Red and Mediterranean seas, and also in the Arctic ocean. Optical imagery collected during these missions are accompanied by standard meteorological observations of cloudiness characteristics made by experienced observers. We assess the generalization ability of the presented models in several scenarios that differ in terms of the regions selected for the train and validation subsets. As a result, we demonstrate that our models based on convolutional neural networks deliver superior quality compared to all previously published schemes. As a key result, we demonstrate considerable drop of the ability to generalize the training data in case of strong covariate shift between training and validation subsets of imagery which may take place in case of region-aware subsampling.
Biofunctionality of Enzymatically Derived Peptides from Codfish (Gadus morhua) Frame: Bulk in vitro Properties, Quantitative Proteomics, and Bioinformatic Prediction
Authors: Jafarpour Ali , Gregersen Simon , Marciel Gomes Rocio , Marcatili Paolo , Hegelund Olsen Tobias , Jacobsen Charlotte , Overgaard Michael T. , Sørensen Ann Dorit Moltke
Published: November 2020

Protein hydrolysates show great promise as bioactive food and feed ingredient and for valorization of side-streams from e.g. the fish processing industry. This study characterizes bulk emulsifying, foaming, and in vitro antioxidative properties of hydrolysates derived from cod frame by application of Alcalase and Neutrase, individually and sequentially as well as the influence of heat-treatment prior to hydrolysis. We present a novel approach that utilizes proteomics data for calculation of weighted mean peptide properties (length, molecular weight, and charge) and peptide-level abundance estimation. Using subsequent bioinformatic prediction of biofunctional properties to describe observed bulk properties, we are able to provide an in-depth hydrolysate characterization not previously seen. All hydrolysates displayed comparable or higher emulsifying activity and stability than sodium caseinate. Heat-treatment significantly increased stability but showed a negative effect on the activity and degree of hydrolysis. Combining peptide abundance with predicted emulsifying activity, we were able to identify several peptides that are likely linked to the observed differences in bulk emulsifying properties. In general, decreased hydrolysis resulted in significantly higher chelating activity, while the opposite was observed for radical scavenging activity. The study highlights the prospects of applying proteomics and bioinformatics for hydrolysate characterization and in food protein science.
Using of Animal Models of Angiogenesis to Confirm a Bidens pilosa-Sourced Polyacetylenic Glucoside Inhibits Angiogenesis Targeting Hypoxia through VEGF and PDIA4 Suppression
Authors: Yang Cheng-Ying , Wong Jhih-Ying , Lin Chuen-Fu , Chang Chih-Yu , Chang Cicero Lee-Tian
Published: November 2020

Simply Summary: Translation of new cancer treatments between pets and human were noticed in comparative oncological investigation. The current study aims at evaluating a polyacetylenic glucoside purified from an edible herb, Bidens pilosa, to present its anti-angiogenic effects. We innovatively find this polyacetylenic glucoside, cytopiloyne, shows anti-angiogenic effect on different in vitro assays and various in vivo animal models under hypoxia. Based on results of this study, cytopiloyne will be a prospective herb angiogenesis inhibitor candidate to control animal or human cancer formation as adjuvant therapy. Abstract: Anti-angiogenesis is a pivotal combination treatment approach in cancer therapy but rare using on companion animals. This study aimed at evaluating the anti-angiogenic effect of a B. pilosa sourced polyacetylenic glucoside, cytopiloyne, on various in vitro assays and in vivo models. We provide evidences showing that CP has anti-angiogenic activities. Firstly, CP inhibited sponge/ Matrigel plug angiogenesis from tumor cells and decreased the survival of tumor cells on hypoxic conditions. Besides, CP declined PKCα protein expression which a protein leads to the growth and spread of tumors under hypoxia. Secondly, inhibitory effects of CP on endothelial angiogenesis were confirmed by chick chorioallantoic membrane assay, tube formation of SVEC4-10 cells and Matrigel plug assay. A dose-dependent CP treatment inhibited 4T1 cells proliferation under hypoxia and migration. It also suppresses VEGF transcription under hypoxia. Finally, we found that CP decreased PDIA4, a novel regulator of cancer growth, expression in endothelial cells. This effect was confirmed by PDIA4 knockout mice with reduced angiogenesis in Matrigel plug assay. Taken together, these results suggest that CP might act as a promising anti-angiogenic herbal agent candidate to be used in animal hypervascularized cancer of veterinary medicine or in combination to control human cancer as adjuvant therapy.
Neural Modelling of APS Thermal Spray Process Parameters for Optimising the Hardness, Porosity and Cavitation Erosion Resistance of Al2O3 -13% TiO2 Coatings
Authors: Szala Mirosław , Łatka Leszek , Awtoniuk Michał , Winnicki Marcin , Michalak Monika
Published: November 2020

The study aims to elaborate a neural model and algorithm for optimising hardness and porosity of coatings and thus ensure that they have superior cavitation erosion resistance. Al2O3-13wt.%TiO2 ceramic coatings were deposited onto 316L stainless steel by atmospheric plasma spray (ASP). The coatings were prepared with different values of two spray process parameters: the stand-off distance and torch velocity. Microstructure, porosity and microhardness of the coatings were examined. Cavitation erosion tests were conducted in compliance with the ASTM G32 standard. Artificial neural networks (ANN) were employed to elaborate the model, and the multi-objectives genetic algorithm (MOGA) was used to optimise both properties and cavitation erosion resistance of the coatings. Results were analysed with Matlab software by Neural Network Toolbox and Global Optimization Toolbox. The fusion of artificial intelligence methods (ANN+MOGA) is essential for future selection of thermal spray process parameters, especially for the design of ceramic coatings with specified functional properties. Selection of these parameters is a multicriteria decision problem. The proposed method made it possible to find a Pareto front, i.e. trade-offs between several conflicting objectives – maximising the hardness and cavitation erosion resistance of Al2O3-13%TiO2 coatings and, at the same time, minimizing their porosity.
Permanência na educação em tempos de Pandemia: reflexões a partir da licenciatura em Letras do IFF
Authors: Felippe Jonis Manhães Sales
Published: November 2020

O presente trabalho analisou os resultados de uma pesquisa quantitativa realizada com estudantes de um curso de licenciatura, em uma instituição pública federal, acerca das suas condições de permanência na educação superior durante a crise sanitária e social vivida no Brasil no ano de 2020. Os dados produzidos foram organizados em gráficos e tabelas e discutidos à luz das legislações e regulamentações recentes no país, do debate teórico sobre desigualdades sociais e educacionais e do perfil nacional dos estudantes da mesma área de  formação produzido pelo INEP, além de dados sobre o perfil do próprio curso antes da pandemia. As conclusões apontam para um processo de degradação das condições de reprodução material dos estudantes e de suas famílias, o que fragiliza a própria ideia de permanência e aponta para o risco de aprofundamento das desigualdades educacionais em uma situação de aulas regulares por meios digitais, conforme possibilidade aberta pelo MEC.
Theoretical-critical dialogues on authoritary membership and evaluation at PNAIC
Authors: Olarte Crisley Monteiro , Ferreira Isabella Fernanda
Published: November 2020

The National Pact for Literacy at the Right Age (PNAIC) aims to alphabetize children until the third year of elementary school. It is subdivided into four axes: Continuing education, Teaching materials, Systematic evaluation, and Management, mobilization and social control. This paper focuses on the axis entitled Management, mobilization and social control, and aims to assess the way the subjects join the program, how they are evaluated, and how they evaluate the PNAIC. In order to analyze the teachers’ adhesion to the Program, four teachers from a school in Ladário-MS, participants of the PNAIC, are interviewed. The methodology adopted is the case study, with semi-structured interviews. Critical Theory is used as reference. The study concludes that teachers may not assess the Program in a negative way. The evaluation system includes questions with multiple answers, none of which leads to negative opinions about the Program. Regarding their participation, teachers do not have the autonomy to choose whether they want to join the Program or not.
Atrial Fibrillation: the Association with Physical Activity and the Effects of Cardiac Rehabilitation
Authors: Bubnova M. G. , Aronov D. M.
Published: November 2020

The purpose of this review was to present modern studies that examine the relationship of physical activity and risk of atrial fibrillation (AF) development and the impact of cardiac rehabilitation programs in patients with all forms of AF. Data of 52 Russian and foreign scientific sources published in 1998- 2020 were presented. In our study, 48 patients with paroxysmal AF after radiofrequency ablation (RFA) were randomly assigned to a physical rehabilitation/standard therapy or control (standard therapy) group. Aerobic physical training was conducted for 6 months 3 times a week. AF is one of the most common cardiac arrhythmias. Despite modern advances, results of treatment of this disease are far from optimal. Many problems of patients with AF can be addressed through enrolment in multidisciplinary cardiac rehabilitation programs. But this question remains open. This is mainly due to the complexity of selection of physical rehabilitation program for patients with AF. It is known that physical activity can trigger an episode of AF. In the following review article, the approaches to functional capacity assessment of patient with AF are described, recommendations for prescribing safe exercise training to achieve a therapeutic effect are presented. Various aspects of the effects of physical rehabilitation are discussed, including its impact on cardiovascular risk factors, influence on atrial remodeling processes and associated biomarkers, prevention of AF progression and occurrence of cardiovascular complications. Results of our own research indicate effectiveness of physical training in patients with AF after RFA: increase in exercise duration by 18.6% (p<0.001) and load by 24.8% (p<0.01) during exercise test, increase in level of everyday physical activity by 23.8% (p=0.001); left atrium dimensions remain stable comparing with control group. That was combined with a decrease of post ablation atrial arrhythmias: after 6 months, they were registered in 4.5% of trained patients vs 17.4% of control group patients (p<0.01). Steady growth in the number of patients with AF and catheter ablation procedures around the world dictates the need for organization of multi-purpose medical rehabilitation.
Untapped Possibilities of Antiischemic Therapy after Acute Myocardial Infarction: Data from the PROFILE-IM Register
Authors: Kalaydzhyan E. P. , Martsevich S. Yu. , Kutishenko N. P. , Sichinava D. P. , Drapkina O. M.
Published: November 2020

Aim. To evaluate the practice of prescribing antianginal/antiischemic therapy in patients who, after acute myocardial infarction (AMI), retained typical clinical manifestations of stable angina.

Material and methods. The registry includes 160 patients who applied to the polyclinic from March 01, 2014 to June 30, 2015 after suffering an AMI. Anti-ischemic therapy was evaluated in patients with typical angina pectoris.

Results. Based on the survey, typical angina attacks were detected in almost a quarter of patients (38 patients – 23.8%). According to the main indicators, patients with typical angina pectoris practically did not differ from the rest of the group of patients, with the exception of a significantly larger proportion of patients with diagnosed ischemic heart disease before AMI and patients under dispensary supervision. Almost all patients received beta-blockers (97.4%), about a third of patients received calcium antagonists (28.9%) or long-acting nitrates (34,2%). During the first year after AMI, second-line drugs were practically not prescribed to enhance antianginal therapy. According to international non-proprietary names, the choice of doctors tended to prescribe bisoprolol, amlodipine, and isosorbide dinitrate. Exacerbation of the disease course with hospitalization for unstable angina pectoris was recorded in 9 (23.7%) patients from the group with typical angina pectoris and in 5 (4.1%) patients in the rest of the group (p<0.001).

Conclusion. In real clinical practice, only a small part of patients with typical angina pectoris receive drug therapy that corresponds to evidence-based medicine; therefore, the unique possibilities of antianginal (anti-ischemic) therapy often remain unrealized.
Validation of the Alpha Defensin Lateral Flow Test for Periprosthetic Joint Infection
Authors: Deirmengian Carl , Madigan John , Kallur Mallikarjuna Sujith , Conway Janet , Higuera Carlos , Patel Robin
Published: November 2020

Background:

The synovial fluid test for alpha defensin has been reported to have an excellent performance in diagnosing periprosthetic joint infection (PJI). The purpose of this study was to evaluate the performance of the lateral flow test for synovial fluid alpha defensin by using the methods of a formal diagnostic accuracy study and to compare its performance with that of the laboratory-based alpha defensin test for PJI.

Methods:

We conducted a diagnostic accuracy study of the index lateral flow immunoassay for synovial fluid alpha defensin relative to the reference 2013 Musculoskeletal Infection Society (MSIS) multicriteria definition of PJI. The study included a prospective multicenter cohort of outpatients with a failed hip or knee arthroplasty and a supplemental control cohort of fresh synovial fluid specimens submitted by physicians for diagnostic PJI testing.

Results:

Among 57 patients with PJI and 248 patients without PJI in the overall prospective patient cohort, the sensitivity and specificity of the alpha defensin lateral flow test were 89.5% (95% confidence interval [CI]: 78.5% to 96.0%) and 94.8% (95% CI: 91.2% to 97.2%), respectively. The sensitivity increased to 94.3% (95% CI: 84.3% to 98.8%) after exclusion of 17 patients with grossly bloody aspirates (>1 million red blood cells/µL). Among the supplemental control cohort of fresh synovial fluid samples, including 65 samples from patients with PJI and 397 from patients without PJI, the sensitivity and specificity of the alpha defensin lateral flow test were 98.5% (95% CI: 91.7% to 100.0%) and 98.2% (95% CI: 96.4% to 99.3%), respectively. A comparison of the sensitivity and specificity of the alpha defensin lateral flow test with those of the alpha defensin enzyme-linked immunosorbent assay (ELISA) in the combined cohort did not demonstrate a significant difference in sensitivity (94.3% [95% CI: 88.5% to 97.7%] compared with 93.0% [95% CI: 87.1% to 96.7%]) or specificity (96.9% [95% CI: 95.3% to 98.1%] compared with 97.8% [95% CI: 96.4% to 98.8%]) (both p > 0.05).

Conclusions:

The results of this study demonstrate the solid diagnostic performance of the alpha defensin test and have resulted in the U.S. Food and Drug Administration (FDA) authorization of the lateral-flow test with an intended use as an aid in the clinical diagnosis of PJI.

Level of Evidence:

Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Pediatric Open Both-Bone Forearm Fracture Stabilized with Titanium and Stainless Steel Stacked Extension Internal Plating
Authors: Hoellwarth Jason Shih , Scannell Brian P.
Published: November 2020

Case:

A 12-year-old male patient sustained a multisegmental both-bone forearm fracture. Definitive stabilization was ulna intramedullary pinning, with stainless steel plating of the radius followed by a titanium plate stacked atop and extending internal fixation. Currently, 36 months after surgery, he experiences no limitations or complications. All hardware remains in situ.

Conclusion:

We believe this is the first description of different material plates in direct contact, of stacked plates, and of 1 plate extending another's fixation. No adverse effects developed.
Suprascapular Nerve Entrapment due to an Ossified Spinoglenoid Ligament After Scapular Fracture
Authors: Cohn Matthew R. , Cregar William M. , Drager Justin , Lu Yining , Garrigues Grant E.
Published: November 2020

Case:

A 46-year-old man underwent open reduction and internal fixation (ORIF) of left scapular, humerus, and clavicle fractures after a snowmobile accident. He subsequently developed severe left infraspinatus weakness with electromyogram evidence of suprascapular entrapment at the spinoglenoid notch. Intraoperatively, suprascapular nerve compression from an ossified spinoglenoid ligament was observed. Scapular hardware was removed, the ossified ligament was resected, and neurolysis was performed. At 6 months postoperatively, the patient demonstrated return of infraspinatus function.

Conclusion:

An ossified spinoglenoid ligament can contribute to suprascapular neuropathy after scapular fracture and ORIF. Open resection of the ossified ligament may lead to improved infraspinatus function.
Promoting traditional foods for human and environmental health: lessons from agroecology and Indigenous communities in Ecuador
Authors: Deaconu Ana Laura , Mercille Geneviève , Batal Malek
Published: November 2020

Background: The displacement of traditional dietary practices is associated with negative nutritional consequences for rural Indigenous people, who already face the brunt of both nutritional inadequacies and excesses. Traditional food (TF) consumption and production practices can improve nutritional security by mitigating disruptive dietary transitions, providing nutrients and improving agricultural resilience. Meanwhile, traditional agricultural practices regenerate biodiversity to support healthy ecosystems. In Ecuador, Indigenous people have inserted TF agricultural and dietary practices as central elements of the country’s agroecological farming movement. This study assesses factors that may promote TF practices in rural populations and explores the role of agroecology in strengthening such factors. Methods: Mixed methods include a cross-sectional comparative survey of dietary, food acquisition, production and socioeconomic characteristics of agroecological farmers (n=61) and neighboring reference farmers (n=30) in Ecuador’s Imbabura province. Instruments include 24-hour dietary recall and a food frequency questionnaire of indicator traditional foods. We triangulate results using eight focus group discussions with farmers’ associations. Results: Compared to their neighbors, agroecological farmers produce and consume more TFs, and particularly underutilized TFs. Farm production diversity, reliance on non-market foods and agroecology participation act on a pathway in which TF production diversity predicts higher TF consumption diversity and ultimately TF consumption frequency. Age, income, market distance and education are not consistently associated with TF practices. Focus group discussions corroborate survey results and also identify affective (e.g. emotional) and commercial relationships in agroecological spaces as likely drivers of stronger TF practices. Conclusions: Traditional food practices in the Ecuadorian highlands are not relics of old, poor and isolated populations but rather an established part of life for diverse rural people. However, many TFs are underutilized. Sustainable agriculture initiatives may improve TF practices by integrating TFs into production diversity increases and into consumption of own production. Agroecology may be particularly effective because it is a self-expanding global movement that not only promotes the agricultural practices that are associated with TF production, but also appears to intensify affective sentiments toward TFs and inserts TFs in commercial spaces. Understanding how to promote TFs is necessary in order to scale up their potential to strengthen nutritional health.
hnRNPK-regulated LINC00263 promotes malignant phenotypes through miR-147a/CAPN2
Authors: Lee Woo Joo , Shin Chang Hoon , Ji Haein , Jeong Seong Dong , Park Mi-So , Won Hong-Hee , Pandey Poonam , Gorospe Myriam , Kim Hyeon Ho
Published: November 2020

Background: Malignant characteristics of cancers, represented by rapid cell proliferation and high metastatic potential, are a major cause of high cancer-related mortality. As a multifunctional RNA-binding protein, heterogeneous nuclear ribonucleoprotein K (hnRNPK) is closely associated with cancer progression in various types of cancers. In this study, we sought to identify hnRNPK-regulated long intergenic non-coding RNAs (lincRNAs) that play a critical role in the regulation of cancer malignancy.Methods: Malignant phenotypes including metastatic and proliferative potential were examined using Transwell invasion assay, cell counting, and colony forming assay. To search for hnRNPK-regulated lincRNAs, RNA sequencing was performed. Using small RNA sequencing followed by antisense oligonucleotide pull-down, lincRNA-associated miRNAs were selected. The association between miRNA and target mRNA was determined by Argonaute 2-immunoprecipitation and luciferase reporter assay. Results: We found that hnRNPK controlled malignant phenotypes including invasiveness, proliferation, and clonogenicity. RNA sequencing and functional studies revealed that LINC00263, a novel target of hnRNPK, is involved in the oncogenic functions of hnRNPK. Knockdown of LINC00263 mitigated the malignant capabilities. Conversely, increased malignant phenotypes were observed in LINC00263-overexpressing cells. We also found that miR-147a negatively regulates LINC00263 via direct interaction, thus suppressing malignant capabilities. Moreover, knockdown of hnRNPK and LINC00263 upregulated miR-147a, indicating that LINC00263 serves as a ceRNA for miR-147a. By analyzing RNA sequencing data and miRNA target prediction, calpain 2 (CAPN2) was identified as a putative target of miR-147a. Ago2-IP and luciferase reporter assay revealed that miR-147a suppressed CAPN2 expression by directly binding to the 3'UTR of CAPN2 mRNA. Additionally, we found that the weakened malignant capabilities following knockdown of hnRNPK or LINC00263 were restored by miR-147a inhibition or CAPN2 overexpression.Conclusions: Our findings demonstrate that hnRNPK-regulated LINC00263 plays an important role in cancer malignancy by acting as a miR-147a decoy and thus upregulating CAPN2.
Impact of Land Use and Land Cover Change on Soil Erosion Using Rusle Model And Gis: A Case of Temeji Watershed, Western Ethiopia
Authors: Moisa Mitiku Badasa , Negash Daniel Assefa , Merga Biratu Bobo , Gemeda Dessalegn Obsi
Published: November 2020

BackgroundThe impact of Land Use/Land Cover (LULC) conversion on soil resources is getting global attention. Soil erosion is one the critical environmental problems worldwide with high severity in developing countries due to land degradation. This study integrates the Revised Universal Soil Loss Equation (RUSLE) model with a Geographic Information Systems (GIS) to estimate the impacts of LU/LC conversion on the mean annual soil loss in Temeji watershed. In this study, LU/LC change of Temeji watershed were assessed from 2000 to 2020 by using 2000 Landsat ETM+ and 2020 Landsat OLI/TIRS images and classified using supervised maximum likelihood classification algorithms. ResultsResults indicates that majority of the LU/LC in the study area is vulnerable to soil erosion. Our findings show that cultivated land had the highest average soil loss rate in Temeji watershed. High soil loss is observed when grass and forest land were converted into cultivated land with mean soil loss of 88.8t/ha/yr and 86.9t/ha/yr in 2020. Results revealed that about 6608.5ha (42.8%) and 8391.8ha (54.4%) were categorized under severe classes in 2000 and 2020, respectively.ConclusionsThe results can definitely support policy makers and environmental managers in implementation of soil and water conservation practices and erosion risk prevention and mitigation strategies in Temeji watershed.
Nutritional status and its concomitant factors among pre-school children in Malda, India: A micro-level study using a multilevel approach
Authors: Sk Rayhan , Banerjee Anuradha , Rana MD Juel
Published: November 2020

The authors have requested that this preprint be removed from Research Square.