bluuebunny/crossref_metadata_2025 huggingface dataset:
Cosmic Evolution of Holographic Dark Energy in f(G,T) Gravity
Authors: Sharif M. , Ikram Ayesha
Published: April 2019

The aim of this paper is to analyze the cosmological evolution of holographic dark energy in f(G,T) gravity (G and T represent the Gauss-Bonnet invariant and trace of the energy-momentum tensor, respectively). We reconstruct f(G,T) model through correspondence scheme using power-law form of the scale factor. The qualitative analysis of the derived model is investigated with the help of evolutionary trajectories of equation of state and deceleration as well as state-finder diagnostic parameters and ωGT-ωGT′ cosmological phase plane. It is found that the equation of state parameter represents phantom epoch of the Universe whereas the deceleration parameter illustrates the accelerated phase. The state-finder plane corresponds to Chaplygin gas model while the freezing region is attained in ωGT-ωGT′ plane.
Numerical Study of Bubble Rising and Coalescence Characteristics under Flow Pulsation Based on Particle Method
Authors: Chen Ronghua , Zhang Minghao , Guo Kailun , Zhao Dawei , Tian Wenxi , Su Guanghui , Qiu Suizheng
Published: April 2019

Two-phase flow instability may occur in nuclear reactor systems, which is often accompanied by periodic fluctuation in fluid flow rate. In this study, bubble rising and coalescence characteristics under inlet flow pulsation condition are analyzed based on the MPS-MAFL method. To begin with, the single bubble rising behavior under flow pulsation condition was simulated. The simulation results show that the bubble shape and rising velocity fluctuate periodically as same as the inlet flow rate. Additionally, the bubble pairs’ coalescence behavior under flow pulsation condition was simulated and compared with static condition results. It is found that the coalescence time of bubble pairs slightly increased under the pulsation condition, and then the bubbles will continue to pulsate with almost the same period as the inlet flow rate after coalescence. In view of these facts, this study could offer theory support and method basis to a better understanding of the two-phase flow configuration under flow pulsation condition.
On the Constructions of New Symmetric Ciphers Based on Nonbijective Multivariate Maps of Prescribed Degree
Authors: Ustimenko Vasyl , Romańczuk-Polubiec Urszula , Wróblewska Aneta , Polak Monika Katarzyna , Zhupa Eustrat
Published: April 2019

The main purpose of this paper is to introduce stream ciphers with the nonbijective encryption function of multivariate nature constructed in terms of algebraic graph theory. More precisely, we describe the two main symmetric algorithms for creation of multivariate encryption transformations based on three families of bipartite graphs with partition sets isomorphic to Kn, where K is selected as the finite commutative ring. The plainspace of the algorithm is Ω={x∣∑xi∈K⁎,  x∈Kn}⊂Kn,Ω≅K⁎×Kn-1. The second algorithm is a generalization of the first one with using the jump operator, where generalized encryption map has an essentially higher degree in comparison with the previous version. Moreover, the degree of this generalized map is not bounded by some constant. This property guarantees resistance of the cipher to linearization attacks.
Modelling the Effect of Mobile Phone Use on Driving Behaviour Considering Different Use Modes
Authors: Spyropoulou Ioanna , Linardou Maria
Published: April 2019

Mobile phone use while driving is a major cause of driver distraction, affecting driving performance and increasing accident risk. Governments have responded to this with the implementation of legislation prohibiting the use of mobile phones, under specific conditions, mainly adopting the hands-free use. Still, mobile phone is a cause of several types of distraction rather than just manual. This study explores the effect of mobile phone use while driving via a simulator experiment. Participants drive under various types of mobile phone use mode- namely, handheld, hands-free (wired earphone), and speaker to capture this effect. Results highlight the effect of mobile phone use, regardless of the use mode, on driving behaviour through specific indicators: maximum driving speed, reaction time, and lateral position. In particular, considering the aforementioned parameters the handheld mode demonstrates safer driving behaviour compared to the speaker mode. The results of this study stress the need for a reconsideration of the present legislation.
Cognitive and Emotional Impairment after Minor Stroke and Non-ST-Elevation Myocardial Infarction (NSTEMI): A Prevalence Study
Authors: Morsund Åse Hagen , Ellekjær Hanne , Gramstad Arne , Reiestad Magnus Tallaksen , Midgard Rune , Sando Sigrid Botne , Jonsbu Egil , Næss Halvor
Published: April 2019

Aim. To study the prevalence of cognitive and emotional impairment following a minor ischemic stroke compared to an age-matched group with non-ST-elevation myocardial infarction (NSTEMI). Methods. We included patients aged 18-70 years with a minor ischemic stroke defined as modified Rankin Scale (mRS) 0-2 at day 7 or at discharge if before and age-matched NSTEMI patients with the same functional mRS. We applied a selection of cognitive tests and the patients completed a questionnaire comprising of Hospital Anxiety and Depression scale (HADS) and Fatigue Severity Scale (FSS) at follow-up 12 months after the vascular event. Results of cognitive tests were also compared to normative data. Results. 325 ischemic stroke and 144 NSTEMI patients were included. There was no significant difference in cognitive functioning between ischemic stroke and NSTEMI patients. Minor stroke patients and to a lesser extent NSTEMI patients scored worse on more complex cognitive functions including planning and implementation of activities compared to validated normative data. For the minor stroke patients the location of the ischemic lesion had no influence on the result. The prevalence of anxiety, depression, and fatigue was significantly higher in the stroke group compared to the NSTEMI group. Depression was independently associated with reduced cognitive function. Discussion and Conclusion. Minor ischemic stroke patients, and to lesser degree NSTEMI patients, had reduced cognitive function compared to normative data, especially executive functioning, on 12-month follow-up. The difference in cognitive function between stroke and NSTEMI patients was not significant. Depression was associated with low scores on cognitive tests highlighting the need to adequately address emotional sequelae when considering treatment options for cognitive disabilities.
An End-to-End Automation Framework for Mobile Network Testbeds
Authors: Díaz Zayas Almudena , García García Bruno , Merino Pedro
Published: April 2019

This paper describes the end-to-end automation framework developed as part of the TRIANGLE project. The TRIANGLE project is devoted to the benchmarking of apps and devices in mobile networks. For that purpose, it is needed to ensure the repeatability in the behaviour of all the components of the mobile network during the execution of the same test. This is why one of the main objectives of the project was to develop an end-to-end automation framework to provide repeatable testing. This paper describes in detail the design and the implementation of the framework.
The Clinical and Economic Burden of Colorectal Anastomotic Leaks: Middle-Income Country Perspective
Authors: Ribeiro Jr. Ulysses , Tayar Daiane O. , Ribeiro Rodrigo A. , Andrade Priscila , Junqueira Jr. Silvio M.
Published: April 2019

Purpose. Anastomotic leaks (AL) present a significant source of clinical and economic burden on patients undergoing colorectal surgeries. This study was aimed at evaluating the clinical and economic consequences of AL and its risk factors. Methods. A retrospective cohort study was conducted between 2012 and 2013 based on the billing information of 337 patients who underwent low anterior resection (LAR). The outcomes evaluated were the development of AL, use of antibiotics, 30-day readmission and mortality, and total hospital costs, including readmissions and length of stay (LOS). The risk factors for AL, as well as the relationship between AL and clinical outcomes, were analyzed using multivariable Poisson regression. Generalized linear models (GLM) were employed to evaluate the association between AL and continuous outcomes (LOS and costs). Results. AL was detected in 6.8% of the patients. Emergency surgery (aRR 2.56; 95% CI: 1.15–5.71, p=0.021), blood transfusion (aRR 4.44; 95% CI: 1.86–10.64, p=0.001), and cancer diagnosis (aRR 2.51; 95% CI: 1.27–4.98, p=0.008) were found to be independent predictors of AL. Patients with AL showed higher antibiotic usage (aRR 1.69; 95% CI: 1.37–2.09, p<0.001), 30-day readmission (aRR 3.34; 95% CI: 1.53–7.32, p=0.003) and mortality (aRR 13.49; 95% CI: 4.10–44.35, p<0.001), and longer LOS (39.6 days, as opposed to 7.5 days for patients without AL, p<0.001). Total hospital costs amounted to R$210,105 for patients with AL in comparison with R$34,270 for patients without AL (p<0.001). In multivariable GLM, the total hospital costs for AL patients were 4.66 (95% CI: 3.38–6.23, p<0.001) times higher than those for patients without AL. Conclusions. AL leads to worse clinical outcomes and increases hospital costs by 4.66 times. The risk factors for AL were found to be emergency surgery, blood transfusion, and cancer diagnosis.
The Effect of EBM Process Parameters on Porosity and Microstructure of Ti-5Al-5Mo-5V-1Cr-1Fe Alloy
Authors: Kurzynowski Tomasz , Madeja Marcin , Dziedzic Robert , Kobiela Karol
Published: April 2019

In this article, the authors discuss the results of studies into the processing of Ti-5Al-5Mo-5V-1Cr-1Fe near-β titanium alloy (Ti-55511) by electron beam melting (EBM), an additive manufacturing technique. Due to its high flexibility in shaping mechanical properties, Ti-55511 alloy is commonly used in aircraft components such as landing gear or airframes. In this study, Ti-55511 powder was used and its properties were described as regards chemical composition and particle size distribution in order to assess its suitability for EBM processing and repeatability of results. 20 sets of processing parameters were tested in the energy input range between 10 J/mm3 and 50 J/mm3 (cathode current, 4.5 mA-19.5 mA; scanning speed, 1080 mm/s–23400 mm/s). Four types of top surfaces were obtained, namely, flat, orange peel, with single pores, and with swelling. Best results were obtained for the energy of 30 J/mm3: flat top surface and relative density in excess of 99.9%. Analysis of chemical composition showed that aluminum loss was below the specification minimum for the analyzed parameter sets. Scanning speed most significantly affected aluminum content: the lower the scanning speed, the higher the aluminum loss. Analysis of microstructures showed the dependence of lamellar α-phase volume fraction on the process parameters used. For low scanning speed, the determined α-phase volume accounted for about 78%. Higher scanning speed resulted in a decrease of the α-phase content to 61%. The dimensions of the lamellas and the amount of the α-phase strongly effected hardness results (360 HV to 430 HV).
An Improved Sliding Window Area Method for T Wave Detection
Authors: Shang Haixia , Wei Shoushui , Liu Feifei , Wei Dingwen , Chen Lei , Liu Chengyu
Published: April 2019

Background. The T wave represents ECG repolarization, whose detection is required during myocardial ischemia, and the first significant change in the ECG signal is being observed in the ST segment followed by changes in other waves like P wave and QRS complex. To offer guidance in clinical diagnosis, decision-making, and daily mobile ECG monitoring, the T wave needs to be detected firstly. Recently, the sliding area-based method has received an increasing amount of attention due to its robustness and low computational burden. However, the parameter setting of the search window’s boundaries in this method is not adaptive. Therefore, in this study, we proposed an improved sliding window area method with more adaptive parameter setting for T wave detection. Methods. Firstly, k-means clustering was used in the annotated MIT QT database to generate three piecewise functions for delineating the relationship between the RR interval and the interval from the R peak to the T wave onset and that between the RR interval and the interval from the R peak to the T wave offset. Then, the grid search technique combined with 5-fold cross validation was used to select the suitable parameters’ combination for the sliding window area method. Results. With respect to onset detection in the QT database, F1 improved from 54.70% to 70.46% and 54.05% to 72.94% for the first and second electrocardiogram (ECG) channels, respectively. For offset detection, F1 also improved in both channels as it did in the European ST-T database. Conclusions. F1 results from the improved algorithm version were higher than those from the traditional method, indicating a potentially useful application for the proposed method in ECG monitoring.
A Novel Task Allocation Algorithm in Mobile Crowdsensing with Spatial Privacy Preservation
Authors: Tang Wenyi , Jin Qi , Zheng Xu , Luo Guangchun , Duan Guiduo , Chen Aiguo
Published: April 2019

The Internet of Things (IoT) has attracted the interests of both academia and industry and enables various real-world applications. The acquirement of large amounts of sensing data is a fundamental issue in IoT. An efficient way is obtaining sufficient data by the mobile crowdsensing. It is a promising paradigm which leverages the sensing capacity of portable mobile devices. The crowdsensing platform is the key entity who allocates tasks to participants in a mobile crowdsensing system. The strategy of task allocating is crucial for the crowdsensing platform, since it affects the data requester’s confidence, the participant’s confidence, and its own benefit. Traditional allocating algorithms regard the privacy preservation, which may lose the confidence of participants. In this paper, we propose a novel three-step algorithm which allocates tasks to participants with privacy consideration. It maximizes the benefit of the crowdsensing platform and meanwhile preserves the privacy of participants. Evaluation results on both benefit and privacy aspects show the effectiveness of our proposed algorithm.
Determinants of Insomnia among Mothers during Postpartum Period in Northwest Ethiopia
Authors: Belete Habte , Misgan Eyaya
Published: April 2019

Objective. Postpartum period is a state of instability that may be accompanied by mood liability, anxiety, insomnia, and neuropsychiatric disturbance in women. This neuropsychiatric disturbance has a negative influence on the child’s psychological and physical development. Our aim was to see the level of sleep difficulties among postpartum mothers in three obstetric care settings in Ethiopia. Method. Institutional based cross-sectional study was conducted at one referral hospital and two health centers. A total of 988 postpartum mothers had been interviewed for sleep difficulties by using Athens Insomnia Scale (AIS). Adjusted Odd Ratio (AOR) and 95% Confidence Interval (CI) were used and P-value <0.05 was used for indicating significant variables. Result. The prevalence of sleep difficulty between four to six weeks of postpartum period was 21.8% (215/988). Marital status of divorced/widowed/separated [AOR= 2.29, 95% CI (1.40, 6.08)], no educational opportunity [AOR= 2.35, 95% CI (1.57, 3.51)], having poor social support [AOR=2.82, 95% CI (1.63, 4.88)], alcohol use [AOR=1.58, 95% CI (1.13, 2.22)], history of depression [AOR=1.93, 95% CI (1.13, 3.31)], and who has poor support from husband [AOR=1.94, 95% CI (1.18, 3.18)] had association with sleep difficulty. Conclusion. There is a high magnitude of sleep difficulties during four to six weeks of postpartum period in postpartum mothers and they are associated with many preventable risk factors.
Effects of Phytoestrogen Supplement on Quality of Life of Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Peng Ching-Ching , Liu Chia-Yu , Kuo Nai-Rong , Tung Tao-Hsin
Published: April 2019

Background. The effect of phytoestrogen on postmenopausal quality of life is unclear. This study evaluated the effects of phytoestrogen supplement on quality of life for postmenopausal women.Methods. We conducted a systematic review and meta-analysis of randomized controlled trials on the effects of phytoestrogen supplements on the quality of life of postmenopausal women. We searched PubMed, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials on March 31, 2018, for relevant randomized controlled trials. Two authors independently selected studies, assessed risk of bias, and extracted data. Disagreement was resolved through discussion with a third author.Results. We involved 10 articles in the systematic review. 8 studies and a total of 1,129 subjects were included in the meta-analysis. The questionnaires used in the evaluation of quality of life were as follows: SF-36, 4 studies; MENQOL, 4 studies; For Short Form 36 surveys, phytoestrogen groups scored significantly higher for body pain (mean difference = 3.85, 95% confidence interval [CI] = [1.14, 6.57],P< 0.01), mental health (mean difference = 4.01, 95% CI = [1.49, 6.57],P< 0.01), and role limitations caused by emotional problems domains (mean difference = 3.83, 95% CI = [1.81, 5.85],P< 0.01). No statistically significant difference was obtained from Menopause-Specific Quality of Life surveys (vasomotor domain mean difference 0.14, 95% CI = [−0.08, 0.36],P= 0.20; physical domain mean difference 0.20, 95% CI [−0.08, 0.48],P= 0.15; psychological domain mean difference −0.10, 95% CI [−0.26, 0.07],P= 0.27; sexual domain mean difference −0.17, 95% CI [−0.42, 0.09],P= 0.19).Conclusion. Current evidence does not support phytoestrogen supplementation improving postmenopausal quality of life. Further comprehensive trials or long-term follow-up studies are warranted.
Transcriptomic Sequencing of Airway Epithelial Cell NCI-H292 Induced by Synthetic Cationic Polypeptides
Authors: Wang Ya-Ni , Xu Yu-Fei , Liang Ya-Xue , Fan Xiao-Yun , Zha Xiao-Jun
Published: April 2019

Eosinophil asthma is characterized by the infiltration of eosinophils to the bronchial epithelium. The toxic cationic protein released by eosinophils, mainly major basic protein (MBP), is one of the most important causative factors of epithelium damage. Poly-L-Arginine (PLA) is a kind of synthetic cationic polypeptides, which is widely used to mimic the effects of MBP on epithelial cells in vitro. However, little is known about the changes of differentially expressed genes (DEGs) and transcriptome profiles in cationic protein stimulated epithelial cells. In this study, we compared the expression of DEGs and transcriptome profiles between PLA-treated airway epithelial cells NCI-H292 and control. The results showed that there were a total of 230 DEGs, of which 86 were upregulated and 144 were downregulated. These DEGs were further analyzed using gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The results showed that the upregulated DEGs were involved in cholesterol synthesis, protein binding, and composition of cellular membranes, mainly enriched in metabolic and biosynthesis pathways. While downregulated DEGs were implicated in cell adhesion, extracellular matrix (ECM) composition and cytoskeleton and were enriched in ECM pathway. In conclusion, our research provided the mechanism of the cationic polypeptides acting on the airway epithelial cells on the basis of transcriptomic profile, and this could be regarded as important indications in unveiling the pathologic role of natural cationic proteins in the damage to epithelial cells of asthmatics.
Utilization of Insecticide Treated Bed Nets (ITNs) among Caregivers of Children under Five Years in the Ho Municipality
Authors: Diema Konlan Kennedy , Japiong Milipaak , Dodam Konlan Kennedy , Afaya Agani , Salia Solomon Mohammed , Kombat Joseph M.
Published: April 2019

Background. In Ghana, attempts to control malaria through antimalarial medications are currently threatened by the emergence and spread of drug resistant malaria parasites. This, together with the increasing incidence of malaria, has heightened the need for a more effective method of controlling the spread. The use of Insecticide Treated Bed Net (ITN) has been recognised as an effective measure in the prevention of malaria. Objective/Purpose. In this study, we examined the utilisation of ITN among caregivers of children under five years in Ho municipality of Ghana. Methods. This descriptive cross-sectional study recruited 283 household representatives through a multistage sampling method. A questionnaire was used to collect the data and was analyzed using STATA version 14. Descriptive and inferential statistics were adopted in presenting the data. Results. Ownership of ITN was higher (80.7%) than its utilisation (41.7%). The age of caregiver was strongly associated with the utilisation of ITN (AOR=2.00, 95% CI=0.00, 0.02, p<0.001) among children less than five years. Caregivers aged 26-35 were 49% times less likely to use an ITN as compared to those aged between 17 and 25 and the difference was statistically significant. Conclusion. In order to ensure a high ITN coverage and utilisation, there is the need for continuous distribution of ITNs to households. Households should be sensitized to use the nets to prevent the continuous spread of malaria.
FPGA Implementation of an Improved Reconfigurable FSMIM Architecture Using Logarithmic Barrier Function Based Gradient Descent Approach
Authors: Das Nitish , P Aruna Priya
Published: April 2019

Recently, the Reconfigurable FSM has drawn the attention of the researchers for multistage signal processing applications. The optimal synthesis of Reconfigurable finite state machine with input multiplexing (Reconfigurable FSMIM) architecture is done by the iterative greedy heuristic based Hungarian algorithm (IGHA). The major problem concerning IGHA is the disintegration of a state encoding technique. This paper proposes the integration of IGHA with the state assignment using logarithmic barrier function based gradient descent approach to reduce the hardware consumption of Reconfigurable FSMIM. Experiments have been performed using MCNC FSM benchmarks which illustrate a significant area and speed improvement over other architectures during field programmable gate array (FPGA) implementation.
What Changed on the Folliculogenesis in the Process of Mouse Ovarian Aging?
Authors: Ye Wenlei , Shen Wei , Yan Wei , Zhou Su , Cheng Jing , Pan Guangxin , Wu Meng , Ma Lingwei , Luo Aiyue , Wang Shixuan
Published: April 2019

There are about 1-2 million follicles presented in the ovary at birth, while only around 1000 primordial follicles are left at menopause. The ovarian function also decreases in parallel with aging. Folliculogenesis is vital for ovarian function, no matter the synthesis of female hormones or ovulation, yet the mechanisms for its changing with increasing age are not fully understood. Early follicle growth up to the large preantral stage is independent of gonadotropins in rodents and relies on intraovarian factors. To further understand the age-related molecular changes in the process of folliculogenesis, we performed microarray gene expression profile analysis using total RNA extracted from young (9 weeks old) and old (32 weeks old) mouse ovarian secondary follicles. The results of our current microarray study revealed that there were 371 (≥2-fold, q-value ≤0.05) genes differentially expressed in which 174 genes were upregulated and 197 genes were downregulated in old mouse ovarian secondary follicles compared to young mouse ovarian secondary follicles. The gene ontology and KEGG pathway analysis of differentially expressed genes uncovered critical biological functions such as immune system process, aging, transcription, DNA replication, DNA repair, protein stabilization, and apoptotic process were affected in the process of aging. The considerable changes in gene expression profile may have an adverse influence on follicle quality and folliculogenesis. Our study provided information on the processes that may contribute to age-related decline in ovarian function.
Acute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages
Authors: Bonilla Ximena , Vanegas Natalia-Del Pilar , Vernot Jean Paul
Published: April 2019

Mesenchymal stem cells (MSC) constitute an important cell population of the bone marrow hematopoietic niche that supports normally hematopoietic stem cells (HSC) but eventually also leukemic cells. The alterations that occur in the MSC under leukemic stress are not well known. To deepen on this topic, we have used an in vitro model of the leukemic niche (LN) by coculturing MSC with an acute lymphocytic leukemia cell line (REH) and proceeded to evaluate MSC characteristics and functions. We found that leukemic cells induced in MSC a significant increase both in senescence-associated β-galactosidase activity and in p53 gene expression. MSC in the LN also showed a persistent production of cytoplasmic reactive oxygen species (ROS) and a G2/M phase arrest of the cell cycle. Another acute leukemic cell line (SUP-B15) produced almost the same effects on MSC. REH cells adhere strongly to MSC possibly as a result of an increased expression of the adhesion molecules VCAM-1, ICAM-1, and CD49e in MSC and of CD49d in REH cells. Although mesensphere formation was normal or even increased, multipotent differentiation capacity was impaired in MSC from the LN. A REH-conditioned medium was only partially (about 50%) capable of inducing the same changes in MSC, suggesting that cell-to-cell contact is more efficient in inducing these changes. Despite these important effects on MSC in the LN, REH cells increased their cell adhesion, proliferation rate, and directed-migration capacity. In conclusion, in this in vitro LN model, leukemic cells affect importantly the MSC, inducing a senescence process that seems to favour leukemic cell growth.
Catalytic Transfer of Fructose to 5-Hydroxymethylfurfural over Bimetal Oxide Catalysts
Authors: Zhang Qiuyun , Liu Xiaofang , Yang Tingting , Pu Quanlin , Yue Caiyan , Zhang Shuya , Zhang Yutao
Published: April 2019

Direct conversion of fructose into 5-hydroxymethylfurfural (HMF) is achieved by using modified aluminum-molybdenum mixed oxide (S-AlMo) as solid acid catalysts. The synthesized catalyst was characterized by powder XRD, nitrogen adsorption-desorption isotherm, NH3-TPD, and SEM. As a result, the presence of strong acidity, mesostructures, and high surface area in the S-AlMo catalyst was confirmed by nitrogen adsorption-desorption isotherm and NH3-TPD studies. A study by optimizing the reaction conditions such as catalyst dosage, reaction temperature, and time has been performed. Under the optimal reaction conditions, HMF was obtained in a high yield of 49.8% by the dehydration of fructose. Moreover, the generality of the catalyst is also demonstrated by glucose and sucrose with moderate yields to HMF (24.9% from glucose; 27.6% from sucrose) again under mild conditions. After the reaction, the S-AlMo catalyst can be easily recovered and reused four times without significant loss of its catalytic activity.
Vibration Analysis of a Single‐Cylinder Reciprocating Compressor considering the Coupling Effects of Torsional Vibration
Authors: Liu Siyuan , Li Wanyou , Shuai Zhijun , Chen Meilong
Published: April 2019

A piston slap is one of the main vibration sources of the reciprocating machinery. Much work has been done in this field, most of which was based on a constant rotating speed. However, in practice, the speed of a crankshaft may always fluctuate due to the uneven load or excitation. The inertia forces of moving components are much different at the fluctuating rotating speed comparing with that at a constant speed. In this paper, the piston slap and the induced vibration are analyzed based on the instantaneous angular speed measured on a single‐cylinder reciprocating compressor. Firstly, the dynamics of a crank‐connecting rod mechanism is analyzed based on the measured instantaneous angular speed which contains the torsional vibration of the air compressor. The time histories of piston slap impact forces considering and without considering torsional vibration are compared. Then, in order to correlate the piston slap impact with the slap‐induced vibration, the corresponding transfer functions between the middle stroke of the outer surface of the cylinder liner and the excitation points are measured. And the excitation force on the main bearing is also taken into account to bring the simulation closer to the experimental results. The effects of a torsional vibration on the vibration of the cylinder liner are analyzed, and the simulation results show that the torsional vibration is a factor that must be taken into account in the vibration analysis of the single‐cylinder reciprocating compressor.
Lyapunov-Type Inequalities for a Conformable Fractional Boundary Value Problem of Order 3<α≤4
Authors: Bachar Imed , Eltayeb Hassan
Published: April 2019

We establish new Lyapunov-type inequalities for the following conformable fractional boundary value problem (BVP): Tαaut+q(t)u(t)=0,  a<t<b,  u(a)=u′(a)=u′′(a)=u′′(b)=0, where Tαa is the conformable fractional derivative of order α∈(3,4] and q is a real-valued continuous function. Some applications to the corresponding eigenvalue problem are discussed.
A Quantum-Based Database Query Scheme for Privacy Preservation in Cloud Environment
Authors: Liu Wenjie , Gao Peipei , Liu Zhihao , Chen Hanwu , Zhang Maojun
Published: April 2019

Cloud computing is a powerful and popular information technology paradigm that enables data service outsourcing and provides higher-level services with minimal management effort. However, it is still a key challenge to protect data privacy when a user accesses the sensitive cloud data. Privacy-preserving database query allows the user to retrieve a data item from the cloud database without revealing the information of the queried data item, meanwhile limiting user’s ability to access other ones. In this study, in order to achieve the privacy preservation and reduce the communication complexity, a quantum-based database query scheme for privacy preservation in cloud environment is developed. Specifically, all the data items of the database are firstly encrypted by different keys for protecting server’s privacy, and in order to guarantee the clients’ privacy, the server is required to transmit all these encrypted data items to the client with the oblivious transfer strategy. Besides, two oracle operations, a modified Grover iteration, and a special offset encryption mechanism are combined together to ensure that the client can correctly query the desirable data item. Finally, performance evaluation is conducted to validate the correctness, privacy, and efficiency of our proposed scheme.
Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research
Authors: Koumpa Foteini Stefania , Xylas Diamantis , Konopka Maciej , Galea Dieter , Veselkov Kirill , Antoniou Anthony , Mehta Akash , Mirnezami Reza
Published: April 2019

Colorectal peritoneal metastases (CPM) are associated with abbreviated survival and significantly impaired quality of life. In patients with CPM, radical multimodality treatment consisting of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated oncological superiority over systemic chemotherapy alone. In highly selected patients undergoing CRS + HIPEC, overall survival of over 60% has been reported in some series. These are patients in whom the disease burden is limited and where the diagnosis is made at an early stage in the disease course. Early diagnosis and a deeper understanding of the biological mechanisms that regulate CPM are critical to refining patient selection for radical treatment, personalising therapeutic approaches, enhancing prognostication, and ultimately improving long-term survivorship. In the present study, we outline three broad themes which represent critical future research targets in CPM: (1) enhanced radiological strategies for early detection and staging; (2) identification and validation of translational biomarkers for diagnostic, prognostic, and therapeutic deployment; and (3) development of optimized approaches for surgical cytoreduction as well as more precise strategies for intraperitoneal drug selection and delivery. Herein, we provide a contemporary narrative review of the state of the art in these three areas. A systematic review in accordance with PRISMA guidelines was undertaken on all English language studies published between 2007 and 2017. In vitro and animal model studies were deemed eligible for inclusion in the sections pertaining to biomarkers and therapeutic optimisation, as these areas of research currently remain in the early stages of development. Acquired data were then divided into hierarchical thematic categories (imaging modalities, translational biomarkers (diagnostic/prognostic/therapeutic), and delivery techniques) and subcategories. An interactive sunburst figure is provided for intuitive interrogation of the CPM research landscape.
Utilization of Cementitious Material from Residual Rice Husk Ash and Lime in Stabilization of Expansive Soil
Authors: Liu Yuyi , Su Yunhe , Namdar Abdoullah , Zhou Guoqing , She Yuexin , Yang Qin
Published: April 2019

Geological disasters often occur due to expansion and shrinkage properties of expansive soil. This paper presents a cementitious material combined with rice husk ash (RHA) obtained from biomass power plants and lime to stabilize expansive soil. Based on compressive and flexural strength of RHA‐lime mortars, blending ratio of RHA/lime was adopted as 4 : 1 by weight for soil stabilization. When mix proportion of RHA‐lime mixture varied from 0% to 20%, specific surface area of stabilized expansive soil decreased dramatically and medium particle size increased. The deformation and strength properties of stabilized expansive soil were investigated through swelling test, consolidation test, unconfined compression test, direct shear test, and so on. With increase in RHA‐lime content and curing time, deformation properties including swelling potential, swelling pressure, compression index, crack quantity, and fineness of expansive soil lowered remarkably; meanwhile, strength properties involving unconfined compressive strength, cohesion, and internal friction angle improved significantly. Considering engineering performance and cost, mix proportion of 15% and initial water content of 1.2 times optimum moisture content were recommended for stabilizing expansive soil. In addition, effectiveness of RHA‐lime to stabilize expansive soil was achieved by replacement efficiency, coagulation reaction, and ion exchange.
Investigation and Validation of Detection of Storage Stability of Difenoconazole Residue in Mango
Authors: Zhao Fangfang , Liu Jingkun , Han Bingjun , Luo Jinhui
Published: April 2019

To investigate the stability of the pesticide residue in storage samples is a part of detection, which is also an improvement to the accuracy of analytical results. In this work, the UPLC-MS/MS method with perfect accuracy and stability was established for determining residues of difenoconazole in mango. The stability of the residue under different temperatures (4°C and −20°C) and media (fruit samples and pretreated sample solution) was investigated. At 0.1 mg/kg, the residue degraded in 6 months by 12% when at −20°C, while in a week by only 12.2% at 4°C. However, when pretreated and preserved in the solution, the residue remained more than 90% for 6–8 weeks. The results indicated that the main causes of degradation are biochemical factors, and the factors are affected by temperature. The findings also provided appropriate conditions for sample storage. This investigation promotes the accuracy in detection and hence guarantees food safety and quality.
A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma
Authors: Pang Ye-Bin , He Jian , Cui Bi-Yu , Xu Sheng , Li Xi-Lei , Wu Man-Ya , Liang Rong , Feng Yan , Guo Xing , Zhang Xue-Hui , Luo Xiao-Ling
Published: April 2019

HCC stem cells were reported as posttreatment residual tumor cells that play a pivotal role in tumor relapse. Fusing dendritic cells (DCs) with tumor cells represents an ideal approach to effectively activate the antitumor immunity in vivo. DC/HCC stem cell vaccine provides a potential strategy to generate polyclonal immune response to multiple tumor stem cell antigens including those yet to be unidentified. To assess the potential capacity of DC/HCC stem cell vaccines against HCC, CD90+HepG2 cells were sorted from the HCC cell line HepG2. DC and CD90+HepG2 and DC and HepG2 fused cells were induced by polyethylene glycol (PEG). The influence of fusion cells on proliferation and immunological function transformation of lymphocytes was assessed by FCM and ELISA assay, respectively. The cytotoxicity assay of specific fusion cell-induced CTLs against HepG2 was conducted by CytoTox 96 Non-Radioactive Cytotoxicity Assay kit in vitro. At last, the prevention of HCC formation in vivo was described in a mouse model. The results of FCM analysis showed that the proportion of CD90+HepG2 cells in the spheral CD90+HepG2 enriched by suspension sphere culture was ranging from 98.7% to 99.5%, and 57.1% CD90+HepG2/DC fused cells were successfully constructed. The fusion cells expressed a higher level of costimulatory molecules CD80, CD83, CD86, and MHC-I and MHC-II molecules HLA-ABC and HLA-DR than did immature DCs (P<0.05). And the functional analysis of fusion cell-induced CTLs also illustrated that CD90+HepG2/DC fusion cells showed a greater capacity to activate proliferation of lymphocytes in vitro (P<0.05). The CD90+HepG2/DC-activated CTLs had a specific killing ability against CD90+HepG2 cells in vivo. These results suggested that CD90+HepG2/DC fusion cells could efficiently stimulate T lymphocytes to generate specific CTLs targeting CD90+HepG2 cells. It might be a promising strategy of immunotherapy for HCC.
Mobilization of Transplanted Bone Marrow Mesenchymal Stem Cells by Erythropoietin Facilitates the Reconstruction of Segmental Bone Defect
Authors: Li Jun , Huang Zeyu , Li Bohua , Zhang Zhengdong , Liu Lei
Published: April 2019

Reconstruction of segmental bone defects poses a tremendous challenge for both orthopedic clinicians and scientists, since bone rehabilitation is requisite substantially and may be beyond the capacity of self-healing. Bone marrow mesenchymal stem cells (BMSCs) have been identified as an optimal progenitor cell source to facilitate bone repair since they have a higher ability for proliferation and are more easily accessible than mature osteoblastic cells. In spite of the potential of BMSCs in regeneration medicine, particularly for bone reconstruction, noteworthy limitations still remain in previous application of BMSCs, including the amount of cells that could be recruited, the compromised bone migration of grafted cells, reduced proliferation and osteoblastic differentiation ability, and likely tumorigenesis. Our current work demonstrates that BMSCs transplanted through the caudal vein can be mobilized by erythropoietin (EPO) to the bone defect area and participate in regeneration of new bone. Based on the histological analysis and micro-CT findings of this study, EPO can dramatically promote the effects on the osteogenesis and angiogenesis efficiency of BMSCs in vivo. Animals that underwent EPO+BMSC administration demonstrated a remarkable increase in new bone formation, tissue structure organization, new vessel density, callus formation, and bone mineral density (BMD) compared with the BMSCs alone and control groups. At the biomechanical level, we demonstrated that combing transplantation of EPO and BMSCs enhances bone defect reconstruction by increasing the strength of the diaphysis, making it less fragile. Therefore, combination therapy using EPO infusion and BMSC transplantation may be a new therapeutic strategy for the reconstruction of segmental bone defect.
Development of an In-Field Method for the Detection of Barium in Various Water Samples Using Differential Pulse Anodic Stripping Voltammetry
Authors: Ridgway S. , Wajrak M.
Published: April 2019

This work presents a reliable, cost-effective, rapid and in-field voltammetric method for the detection of barium. The optimized method consists of an ultrathin mercury film deposited in situ on a glassy carbon electrode in dilute potassium chloride without deoxygenation, using differential pulse anodic stripping voltammetry (DP-ASV). Application of the method allowed for the quantitative determination of barium concentration in a variety of waters and brake pad dust samples. Comparative analysis of sample results from DP-ASV with inductively coupled plasma mass spectroscopy (ICP-MS) showed a mean percent difference of 1.8%.
L-Fuzzy Prime Ideals in Universal Algebras
Authors: Alaba Berhanu Assaye , Addis Gezahagne Mulat
Published: April 2019

In this paper, the notions ofL-fuzzy prime ideals and maximalL-fuzzy ideals of universal algebras are introduced by applying the general theory of algebraic fuzzy systems.
Modular Motion-Structure Design Model for Planetary Surface Sampling
Authors: Li Qian , Xie Lanlan , Li Junping
Published: April 2019

Because there are less restrictions in space, a variety of different movement patterns and equipment structures may be used during the process of planetary surface sampling. Traditionally, the optimal analysis for surface sampling is focused on specific equipment structures and movements; in contrast, a new modular motion-structure design model for surface sampling, which is a more flexible model, is discussed in this paper. By establishing and combining two basic module groups, namely, the motion group and the structure group, this new design model can define and analyse multiple movement patterns and structures. For the motion group, calculating the sampling trajectory is the main purpose, in which there are two basic modules: tridimensional uniform rectilinear movements and tridimensional uniform circular movements. The two basic motion modules can be freely combined in a given coordinate system to simulate a random sampling trajectory. The structure group contains a series of curved and flat plates, which can be defined by a set of unified parameters (including section, extension, and cutting parameters). By assigning different values to these parameters, the curved or flat plates can represent different external shapes. The different structures of the various pieces of surface sampling equipment can be simulated by combining these different plates. In addition to defining these basic modules, analysing the coupling among different modules, which can be simplified to the relationship between velocity and surface, plays an important role in establishing this design model. Based on the modular design theory, this new model will not only reduce the difficulty of analysis but also improve accuracy for planetary surface sampling.
Probable RBD Associates with the Development of RLS in Parkinson’s Disease: A Cross-Sectional Study
Authors: Qu Yewei , Zhang Lu , Shen Dongfang , Zhang Wangzikang , Zhang Mingsha , Pan Yujun
Published: April 2019

Objectives. We aimed to investigate the prevalence of restless leg syndrome (RLS) and exploring the contributing factors that affect the development of RLS in Parkinson’s disease (PD) patients. Methods. A cross-sectional study was conducted consisting of 178 consecutive PD patients from our hospital between October 2015 and August 2016. We divided the participants into two groups, which were PD with RLS and PD with non-RLS. Then, we recorded their demographics and clinical data to draw a comparison between PD with RLS and PD with non-RLS. Results. 23 (12.92%) were diagnosed with RLS among all the enrolled PD patients. Unified Parkinson’s Disease Rating Scale III (UPDRS III) and Hamilton Depression Scale (HAMD) scores, probable rapid eye movement sleep behavior disorder (PRBD), and daily levodopa equivalent dose (LED) in the PD with the RLS group were significantly different from those in the PD with the non-RLS group. Daily LED and the scores of UPDRS III and HAMD in PD patients with RLS were all higher than those in PD patients with non-RLS. PRBD, daily LED, and HAMD scores were significantly independent factors contributing to the development of RLS (OR=4.678, 95% CI 1.372~15.944, P=0.014; OR=1.003, 95% CI 1.001~1.005, P=0.019; OR=1.094, 95% CI 1.002~1.193, P=0.045). The severity of RLS was positively correlated with the duration of PD and daily LED (r=0.438, P=0.036; r=0.637, P=0.001). Conclusion. PRBD existence, daily LED, and HAMD scores are independent factors for developing RLS in PD patients. PRBD existence is firstly proposed as an independent factor in developing RLS among PD patients. RLS severity in PD patients are positively associated with the duration of PD and daily LED.
Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail
Authors: Cortés-Medina Lorena V. , Pasantes-Morales Herminia , Aguilera-Castrejon Alejandro , Picones Arturo , Lara-Figueroa Cesar O. , Luis Enoch , Montesinos Juan Jose , Cortés-Morales Victor A. , De la Rosa Ruiz M. P. , Hernández-Estévez Erika , Bonifaz Laura C. , Alvarez-Perez Marco Antonio , Ramos-Mandujano Gerardo
Published: April 2019

Human mesenchymal stem cells (MSCs) are good candidates for brain cell replacement strategies and have already been used as adjuvant treatments in neurological disorders. MSCs can be obtained from many different sources, and the present study compares the potential of neuronal transdifferentiation in MSCs from adult and neonatal sources (Wharton’s jelly (WhJ), dental pulp (DP), periodontal ligament (PDL), gingival tissue (GT), dermis (SK), placenta (PLAC), and umbilical cord blood (UCB)) with a protocol previously tested in bone marrow- (BM-) MSCs consisting of a cocktail of six small molecules: I-BET151, CHIR99021, forskolin, RepSox, Y-27632, and dbcAMP (ICFRYA). Neuronal morphology and the presence of cells positive for neuronal markers (TUJ1 and MAP2) were considered attributes of neuronal induction. The ICFRYA cocktail did not induce neuronal features in WhJ-MSCs, and these features were only partial in the MSCs from dental tissues, SK-MSCs, and PLAC-MSCs. The best response was found in UCB-MSCs, which was comparable to the response of BM-MSCs. The addition of neurotrophic factors to the ICFRYA cocktail significantly increased the number of cells with complex neuron-like morphology and increased the number of cells positive for mature neuronal markers in BM- and UCB-MSCs. The neuronal cells generated from UCB-MSCs and BM-MSCs showed increased reactivity of the neuronal genes TUJ1, MAP2, NF-H, NCAM, ND1, TAU, ENO2, GABA, and NeuN as well as down- and upregulation of MSC and neuronal genes, respectively. The present study showed marked differences between the MSCs from different sources in response to the transdifferentiation protocol used here. These results may contribute to identifying the best source of MSCs for potential cell replacement therapies.