bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN BAHAN AJAR INTERAKTIF DENGAN MENGGUNAKAN APLIKASI LECTORA INSPIRE UNTUK MAHASISWA PENDIDIKAN BAHASA DAN SASTRA INDONESIA
Authors: Yuli Kurniawan Prasetyo
Published: August 2021

Tujuan penelitian yaitu mendeskripsi kebutuhan berdasarkan persepsi dosen dan mahasiswa tentang pengembangan bahan dan mengidentifikasi uji validasi bahan ajar. Metode penelitian ini yaitu penelitian dan pengembangan (Research and Development). Tahapan penelitian ini mengadaptasi dari Borg and Gall yang dilaksanakan dalam beberapa tahap yaitu tahap awal pengembangan, tahap pengembangan, dan tahap uji. Prosedur pengumpulan data pada tahap awal pengembangan menggunakan teknik wawancara, angket, dan dokumentasi. Sedangkan pengumpulan data pada tahap uji menggunakan teknik angket dan teknik tes. Teknik angket digunakan untuk menilai bahan ajar interaktif oleh validator. Teknik analisis data terdiri atas tiga bagian yaitu pertama, teknik analisis kebutuhan bahan ajar yang diperoleh dari hasil angket kebutuhan mahasiswa dan dosen dianalisis dengan mengelompokkan, menyelesi, dan menyimpulkan data dari hasil pengisian angket kebutuhan. Kedua, teknik analisis data uji validasi dianalisis dalam skor hasil validasi dari rentang 10 – 100 dan penyimpulan kategori berupa baik, cukup, atau kurang. Hasil penelitian tentang analisis kebutuhan pengembangan bahan ajar berdasarkan persepsi dosen dan mahasiswa sudah memenuhi kebutuhan dengan prosentasi terbesar. Kemudian draf bahan ajar sudah disesuaikan dengan kebutuhan persepsi dosen dan mahasiswa. Berdasarkan uji validasi menerangkan bahwa bahan ajar interaktif memeroleh skor 81 (kategori baik)
Simultaneous Adsorption of Chromium and Acidic Dye from Leather Tannery Model Wastewater Using a Novel Modified Nanoclay
Authors: Sorkhabi Mahsa Golghasemi , Aghdasinia Hassan , Oskui Fatemeh Notghi , Karimi Afzal , Golizadeh Mortaza
Published: August 2021

Simultaneous removal of Cr^3+ and acidic dye from model tannery wastewater was investigated using local nano clay modified by 3-chloro-2-hydroxypropyltrimethylammonium chloride (CHPTAC) surfactant. X-ray fluorescence (XRF), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), carbon, hydrogen, nitrogen and sulfur analysis (CHNS), Brunauer-Emmet-Teller (BET) analysis and pH of zero point charge (pH_ZPC) analyses were carried out for characterization of the adsorbent, and adsorptive properties of the modified clay were investigated by batch experiments. The effects of essential parameters, such as adsorbent dosage, initial solution pH, initial solution concentration, contact time, and temperature, were studied. Maximum adsorption values (99.74% for Cr^3+ and 83.26% for dye) were obtained in the following conditions: pH of 4, initial concentration of 100 mg/L, adsorbent dosage of 15000 mg/L, contact time of 30 min. The effect of contaminants’ concentration was also investigated through response surface methodology (RSM), central composite face-centered (CCF) design and an empirical model was presented. The results of kinetic models’ studies demonstrated that simultaneous adsorption of contaminants follows the pseudo-second-order model, and the adsorption data of single and binary solutions fitted nonlinearly to isotherm models showed that the adsorption of Cr (III) from binary and single solutions follow Langmuir and Dubinin-Radushkevitch (D-R) isotherms, respectively. Adsorption of dye from both single and binary solutions follows Redlich- Peterson (R-PT) isotherm. Maximum adsorption capacities were obtained to be 193.1390 mg/g and 144.1782 mg/g for Cr^3+ and dye, respectively. Synergistic and antagonistic adsorptions were observed in binary solutions.
On the occurrence of a less usual rainfall pattern in northeastern Brazil during the 2019 El Niño
Authors: Godoi Victor Azevedo , de Andrade Felipe M.
Published: August 2021

El Niño is generally associated with below-average rainfall in northeastern Brazil (NEB). In 2019, however, the opposite rainfall pattern was observed during an El Niño episode. Here, we explore the mechanisms that overwhelmed typical El Niño-related conditions and resulted in above-average rainfall in NEB. We focus on the austral autumn, when El Niño is most related to rainfall anomalies in the region. The analysis of rainfall data from weather stations and the Global Precipitation Climatology Project, upper- and lower-level circulation reanalysis data, sea surface temperature data, outgoing longwave radiation data, and modelled data allowed us to identify that the autumn 2019 heavy rainfall in NEB was likely associated with three combined factors; these are: (1) the weak intensity of the 2019 El Niño; (2) local and remote diabatic heating anomalies, especially over the western South Pacific and tropical South Atlantic, which resulted in anticyclonic and cyclonic circulations in the upper and lower troposphere, respectively, over the tropical South Atlantic; and (3) sub-seasonal atmospheric convection anomalies over the western South Pacific, which reinforced the low-frequency convection signal over that region. This latter factor suggests the influence of the Madden–Julian Oscillation on rainfall in NEB during the first ten days of March. We discuss these mechanisms in detail and provide evidence for their associations with the anomalously heavy rainfall in NEB. Our results may assist in the planning of several crucial activities, such as water resources management and agriculture.
Pros and Cons of Self Driving Vans - A Real Life Motorway Case Study Analysis from Great Britain
Authors: Nandakumar Ramjit
Published: August 2021

Given the speculations that autonomous vehicles are sure to take over the transport sectors in the near future, this study micro-simulates the impacts of automating the vehicle VAN using the micro-simulation software AIMSUN in a hypothetical condition. This study analyses the impacts of automation of vans in different levels of automation penetrations with heterogeneous traffic conditions on traffic parameters such as speed and different environmental factors and should only be considered as a case approach with minimal application in the real-world scenario. In this study, the impacts of automation of van in different road characteristics were also analyzed in detail. The study highlights that with an increase in van automation penetrations, traffic parameters speed is positively impacted while negative impacts on environmental conditions are observed. This is mostly because multiple analysis should have been carried out to have a complete understanding of the network.
Tumor Suppressor Functions of miRNA-375 in Nasopharyngeal Carcinoma through Inhibition of Ubiquitin-Specific Protease 1 Expression
Authors: Jiayuan Xu , Bangliang Li , Wei Song , Longhe Cao , Chuansai Zhu , Sen Lin
Published: August 2021

Background: Nasopharyngeal carcinoma (NPC) development involves many genetic alterations. This study profiled differentially expressed miRNAs and selected miR-375 for further study.Methods: Differentially expressed miRNAs (DE-miRNAs) were screened using online databases and subjected to various analyses. miR-375 mimics with negative control cDNA, and ubiquitin-specific protease 1 (USP1) as well as a vector-only control were transfected into NPC cells for analysis by quantitative PCR, western blotting, wound healing, Transwell, cell viability, flow cytometry, and luciferase gene reporter assays.Results: A total of 308 NPC and 23 normal tissues were analyzed, and 67 DE-miRNAs were identified. Among these, miR-375 was downregulated and miR-21-5p was upregulated. Bioinformatical analysis identified USP1 as a potential target gene of miR-375. Furthermore, miR-375 expression was decreased, whereas USP1 expression was increased in NPC. Increased USP1 expression was associated with poor survival of head and neck cancer patients. The luciferase assay confirmed miR-375 binding to the USP1 3'-untranslated region (UTR), while the transfection experiment confirmed miR-375 expression reduced USP1 expression, and USP1 overexpression reversed the anti-tumor activity of miR-375 in NPC cells, determined by tumor cell migration, invasion, apoptosis, and gene expression. In addition, USP1 overexpression activated phosphoinositide 3-kinase (PI3K) signaling, whereas a selective PI3K inhibitor (S2793) could reverse the effects of USP1 on NPC cells in vitro.Conclusions: This study confirmed decreased miR-375 expression and increased miR-21 expression in NPC tissues. Downregulated miR-375 expression led to USP1 upregulation, which in turn activated PI3K/Akt signaling and promoted NPC cell migration and invasion, but inhibited NPC cell apoptosis.
Association of Multiple Tumor Markers with gastric cancer patients
Authors: Li Xiaoyang , Li Sifeng , Zhang Zhenqi , Huang Dandan
Published: August 2021

BackgroundTo explore the correlation between multiple tumor markers and gastric cancer. MethodsWe selected 268 newly-treated patients with gastric cancer and 209 healthy subjects for correlation research. The detection of multiple tumor markers was based on protein chip, and then the results were statistically analyzed by SPSS. Results(1)We concluded that gastric cancer was significantly related to gender, age, AFP, CEA, CA125, CA199, and CA242 (P＜0.001). After CA199 and CA242 were stratified by gender, the OR of the male was 30.400 and 31.242 respectively, while the OR of the female was 3.424. After CA125 was stratified by age, among patients with gastric cancer over 54 years old, The risk of occurrence in the CA125-positive population was 16.673 times that in CA125-negative patient; and among patients less than or equal to 54 years old, CA125-positive was not a risk factor for gastric cancer(P=0.082); (2)AFP, CEA, CA125, CA199, CA242 in M1 stage were statistically significant compared with M0 stage and control group (P<0.001), but AFP (P=0.045) and CA125 (P=0.752) were not statistically significant compared with M0 stage and control group; (3)The combined detection sensitivity of multiple tumor markers were 41.79%.ConclusionsOur research shows that gastric cancer is associated with age, gender, and the positive of AFP, CEA, CA125, CA199, and CA242. The positive of AFP and CA125 is related to the distant metastasis of gastric cancer; The combined detection of multiple tumor markers can be used for initial screening of gastric cancer to a certain extent.
Sedimentary Environment Analysis of Eocene in Pingtai Area of Qaidam Basin, China
Authors: yun Jiang , Guoqiang Sun , Shile Pan , yetong Wang , shuncong Zhang
Published: August 2021

The Pingtai area is a relatively new oil and gas exploration area in Qaidam Basin, China. As one of the most important sandstone reservoir in the Qaidam Basin, Eocene Lulehe Formation and Xiaganchaigou Formation. Based on the petrological characteristics and element geochemistry of core samples, the paleosalinity and paleoclimate changes are discussed. The results show that the clay mineral assemblage of the Lulehe Formation consists of smectite, chlorite, and illite; while the clay minerals in the Xiaganchaigou Formation consist of illite/smectite mixed layer, chlorite, and illite. The paleosalinity calculated using the B content and Sr/Ba and Rb/Sr ratios indicates that the Lulehe Formation was formed in a freshwater environment, and the Xiaganchaigou Formation was formed in alternating brackish water and fresh water environments. The chemical weathering index (CIA), La/Th ratio, and Eu anomaly index indicate that the overall chemical weathering in the Pingtai area was weak, the provenance was relatively stable, and the influence of diagenesis on the clay minerals and the trace element contents was negligible. From the Lulehe Formation to the Xiaganchaigou Formation, the paleoclimate gradually changed from warm and humid to cold with humid-dry seasonal changes, which is consistent with the global decrease in temperature in the Eocene. Moreover, because of the uplift of the Altun Mountain and the global cooling, the rainfall decreased, resulting in the Xiaganchaigou Formation being formed in a higher salinity environment.
Efficacy of Bivalent CEACAM6/4-1BBL Genetic Vaccine Combined with Anti-PD1 Antibody in HCT116 Xenograft Mice
Authors: Li Yuzhen , Zhu Xiaodan , You Jianliang , Zhang Baonan , Huang Xiaona , Jin Chunhui
Published: August 2021

Background:Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Anti-PD1/PD-L1 drugs are feasible treatment for CRC, and genetic vaccine is a promising immunotherapy for cancers. However, anti-tumor efficacy of genetic vaccines including CEACAM6/4-1BBL genes combined with immunocheckpoint inhibitors on CRC has not been reported. We used human colon cancer cell line (HCT116) to establish a xenograft mouse model, and applied [89Zr]-labeled PD-L1 antibody ([89Zr]KN035) for PET imaging. Methods:Attenuated Salmonella typhimurium 3261 was transformed by eukaryotic expression plasmid containing CEACAM6/4-1BBL genes as an anti-tumor vaccine, and the combined anti-tumor immunotherapy with bivalent genetic vaccine and anti-PD1 antibody was conducted. MicroPET was performed to non-invasively and dynamically observe the changes of tumor tissues and expression of PD-L1. Results:We found that the recombinant double-gene plasmids were stably expressed in COS7 cells. The findings showed PD-L1 expression in HCT116 tumor model, and thus anti-PD1/PD-L1 drug was suitable for the treatment and [89Zr]KN035 could be used in whole-body PET imaging for in vivo observation of the model. Efficacy observation results of tumor growth, PET scanning and immunohistochemical assays showed that the combined therapy had obvious improvement in effectiveness over vaccine alone.Conclusions:This study supports that combination of genetic vaccines and anti-immunocheckpoint immunotherapy can inhibit HCT116 tumor growth and provide better efficacy via overcoming the immune tolerance and suppressive microenvironment and inhibiting the immune brake induced by immunocheckpoint activation.
Lake Surface Area Forecasting Using Integrated Satellite-SARIMA-Long-Short-Term Memory Model
Authors: Soltani Keyvan , Azari Arash , Zeynoddin Mohammad , Amiri Afshin , Ebtehaj Isa , Ouarda Taha B.M.J. , Gharabaghi Bahram , Bonakdari Hossein
Published: August 2021

Lake Water Surface Area (WSA) plays a vital role in environmental preservation and future water resource planning and management. Accurately mapping, monitoring and forecasting Lake WSA changes are of great importance to regulatory agencies. This study used the MODIS satellite images to extract a monthly time series of WSA of two lakes located in Iran from 2001 to 2019. Following a consequence of image and time series preprocessing to obtain the preprocessed lake surface area time series, the outcomes were modeled by the Long-Short-Term Memory (LSTM) deep learning (DL) method, the stochastic Seasonal Auto-Regressive Integrated Moving Average (SARIMA) method and hybridization of these two techniques with the objective of developing WSA forecasts. After separate standardization and normalization of AL TS and reevaluation of the preprocessed data, the SARIMA (1, 0, 0) (0, 1, 1)12 model outperformed sole LSTM models with correlation index of (R) 0.819, mean absolute error (MAE) of 49.425 and mean absolute percentage error (MAPE) of 0.106. On the other hand, the hybridization (stochastic-DL) enhanced the reproduction of the primal statistical properties of WSA data and caused better mediation. However, the other accuracy indices did not change markedly (R 0.819, MAE 49.310, MAPE 0.105). The multi-step preprocessing and reevaluation also caused all LSTM models to produce their best results by less than 12 inputs.
Discriminative Aging Subspace Learning for Age Estimation
Authors: Sawant Manisha , Bhurchandi Kishor
Published: August 2021

Hidden factor analysis ( HFA ) has been widely used in age invariant face recognition systems. It decomposes facial features into independent age factor and identity factor. Age invariant face recognition systems utilize identity factor for face recognition; however, the age factor remains unutilized . The age component of the hidden factor analysis model depends on the subject's age, hence it carries a significant age related information. In this paper, we propose the HFA model based discriminative manifold learning method for age estimation. Further, multiple regression methods are applied on low dimensional features learned from the aging subspace. Extensive experiments are performed on a large scale aging database MORPH II and the accuracy of our method is found superior to the current state-of-the-art methods.
Thematic Dynamics of Internet of Things (IoT): Impact on Digital Personalized Healthcare (PHC)
Authors: Lainjo Bongs
Published: August 2021

Background: Information technology has continued to shape contemporary thematic trends. Advances in communication have impacted almost all themes ranging from education, engineering, healthcare, and many other aspects of our daily lives. Method: This paper attempts to review the different dynamics of the thematic IoT platforms. A select number of themes are extensively analyzed with emphasis on data mining (DM), personalized healthcare (PHC), and thematic trends of a select number of subjectively identified IoT-related publications over three years. In this paper, the number of IoT-related-publications is used as a proxy representing the number of apps. DM remains the trailblazer, serving as a theme with crosscutting qualities that drive artificial intelligence (AI), machine learning (ML), and data transformation. A case study in PHC illustrates the importance, complexity, productivity optimization, and nuances contributing to a successful IoT platform. Among the initial 99 IoT themes, 18 are extensively analyzed using the number of IoT publications to demonstrate a combination of different thematic dynamics, including subtleties that influence escalating IoT publication themes. Results: Based on findings amongst the 99 themes, the annual median IoT-related publications for all the themes over the four years were increasingly 5510, 8930, 11700, and 14800 for 2016, 2017, 2018, and 2019 respectively; indicating an upbeat prognosis of IoT dynamics. Conclusion: The vulnerabilities that come with the successful implementation of IoT systems are highlighted including the successes currently achieved by institutions promoting the benefits of IoT-related systems like the case study. Security continues to be an issue of significant importance.
Khali pete thaka to teni xadharan*: Lived Experience of Food among Women in Assam
Authors: Bhagawati Purabi , S.S Sumesh
Published: August 2021

The paper explores the lived experiences of food among women from multiple locations of caste, class, tribe, religion and region within Assam, India. The everyday experience of women from Namasudra, Bodo and Char based Muslim communities in Nalbari district forms the empirical context. The various ways of production, procurement, preparation, distribution and consumption of food in these communities are explored. All these practices in general reflect the embodied patriarchal values. The women’s body and nutrition become important for the community when she is pregnant. Here the women have minimal negotiating power, but there has been some resistance of late. Thus, it is argued that the dynamics of conforming and resistance to the dominant practices has to be located in the intersectional matrix of social reality.
The Baseline Serum Uric Acid as an Indicator of Chemotherapy-related Adverse Reaction and Mortality in Aged Males with Stage IIIB or IV Non-small Cell Lung Cancer
Authors: Chen Xiaoyan , Hou Lisha , Li Jianqun , Shen Yanjiao , Dong Birong , Hao Qiukui
Published: August 2021

Objective: To evaluate the accuracy of baseline serum uric acid (BSUA) in estimating adverse effects (AE) and all-cause mortality (ACM) in older males with stage IIIB or IV non-small cell lung cancer (NSCLC) diagnosis.Methods: All patients data was obtained based on medical reports and mortality information was gathered via telephone interviews. BUSA was assessed prior to chemotherapy. Additionally, the end points of this study included chemotherapy-mediated AE and ACM. Binary logistic regression analysis was used to explore the correlation between BSUA and AE. Lastly, Cox regression analysis was utilized to examine the impact of BSUA on ACM.Results: 317 male patients with NSCLC were eligible for this study. Within this population, 18.3% had stage IIIB and 81.7% had stage IV NSCLC. Moreover, 81.39% suffered from adenocarcinoma lung cancer (ACLC), whereas 18.61% suffered from squamous cell carcinoma lung cancer (SCCLC). As of March 1, 2019, 257 (81.07%) patients expired. Following the initial chemotherapeutic course, short-term AE like bone marrow suppression, all infection, liver dysfunction, and digestive reactions, were observed in 13.25%, 7.26%, 5.36%, and 4.1% of cases, respectively. Upon normalizing with confounding factors, the adjusted logistic regression model demonstrated that the moderate BSUA was independently linked to a lower risk of bone marrow suppression (OR=0.407,95% CI:0.178-0.931; p=0.033). Moreover, based on the Cox regression analysis, moderate BSUA was also independently correlated with a low mortality risk (HR=0.705, 95% CI:0.518-0.959; p=0.026).Conclusion：In males patients with stage IIIB or IV NSCLC, BSUA is intimately linked to chemotherapy-driven AE and ACM.
The Dynamics of Neutralizing Antibody Level in One Year After SARS-CoV-2 Infection
Authors: Liang Dan , Zhang Guanting , Huang Mingxing , Hong Wenshan , Li An'an , Liang Yufeng , Wang Tao , Lu Jiahui , Ou Mengdang , Ren Zhongqiang , Lu Huiyi , Zheng Rutian , Cai Xionghui , Pan Xingfei , Xia Jinyu , Ke Changwen
Published: August 2021

Background: A lot of recent researches have focused on the duration of the nature immunity elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. An improved understanding of the immunity offered by the antibodies developed against SARS-CoV-2 in recovered patients is critical for the development of diagnostic tests and vaccines. Methods: We enrolled 114 donors, which providing blood samples after discharge for half a year and one year. Neutralizing antibodies (NAbs) were tested using a micro-neutralization assay. Results: In two tests, 82 of 114 recovered patients completed the first test half a year after discharge and NAbs remained detectable in the vast majority of patients (75/82, 91.46%). In the comparison of the two intervals, 50% (27/54) of individuals had increased NAbs titers. when 31.48% (17/54) of patients remained unchanged. Conclusion: Our results suggest that immune ability is acquired in most individuals infected with SARS-CoV-2 and is sustained in a majority of patients for up to a year after recovery.
Mad, Sad, or Sleepy? Relationships between Postpartum Maternal Anger, Depression, and Sleep: A Cross-Sectional Survey Study
Authors: Ou Christine H. , Hall Wendy A. , Rodney Paddy , Stremler Robyn
Published: August 2021

Background: Although some women experience anger as a mood problem after childbirth, postpartum anger has been neglected by researchers. Poor maternal and infant sleep quality during the postpartum period has been associated with depressive symptoms; however, links between sleep quality and postpartum anger are unclear. This study aimed to determine the proportions of women with significant anger, depressive symptoms, and comorbid anger and depressive symptoms, and to examine maternal and infant sleep quality as correlates of postpartum anger. Methods: This cross-sectional survey study was advertised as an examination of mothers’ and babies’ sleep. Women, with healthy infants between 6 and 12 months of age, were recruited using social media. The survey contained validated measures of maternal and infant sleep quality, and maternal fatigue, social support, anger, depressive symptoms, and cognitions about infant sleep. Results: 278 women participated in the study. Thirty-one percent of women (n = 85) reported high anger levels (≥ 90th percentile on State Anger Scale) while 26% (n = 73) of mothers indicated probable depression (>12 on Edinburgh Postnatal Depression Scale). Women reported a mean of 6.2 hours of sleep (SD = 1.2 hours, range = 4 – 9 hours); over half of the participants rated their sleep as poor (n = 144, 51.8 %). Using robust regression analysis, income (b = -0.74, p < 0.05), parity (b = 2.05, p < 0.01), depressive symptoms (b = 0.59, p < 0.01), maternal sleep quality (b = 0.98, p < 0.05), and maternal anger about infant sleep (b = 0.50, p < 0.01) were significant predictors of maternal anger. Conclusions: Maternal sleep quality and anger about infant sleep are associated with maternal state anger. Clinicians should educate families about sleep pattern changes during the perinatal time frame and assess women’s mood and perceptions of maternal and infant sleep quality in the first postpartum year. They can also offer evidence-based strategies for improving parent-infant sleep. Such health promotion initiatives could reduce maternal anger and support healthy maternal-infant sleep.
North American Fire Weather Catalyzed by the Extratropical Transition of Tropical Cyclones
Authors: Allen Jacob John Stuivenvolt , Wang S.-Y. Simon
Published: August 2021

When tropical cyclones in the western North Pacific turn into midlatitude cyclones, it often perturbs the jet stream, resulting in amplified flow conditions in the north Pacific and various weather extremes in North America. Thus far, however, the complex impacts of extratropical transitioning cyclones (ETCs) on North American fire weather are undocumented. In this study, we group ETCs by the characteristics that are important for their interaction with the jet stream and document the response in North American fire weather, finding that ETCs are consistently associated with enhanced fire weather in North America through amplified pressure gradients and anomalous winds. While the chaotic nature of the ETC and jet stream interaction means that ETCs grouped by similar characteristics and locations can result in varying downstream responses, the composite analysis reveals some areas of consistently enhanced fire weather, including the Pacific Northwest and northern Intermountain West. At a time in which the risk and extent of wildfires in the Western United States is an issue of growing concern, this study represents the first holistic understanding of how ETCs’ downstream perturbations impact fire weather.
Community Analysis of Nematodes Associated with Banana, Identification of root knot nematode and Evaluation the Susceptibility of Some Cultivars to Infection
Authors: Mostafa Radwa G. , El-Zawahry Aida M. , Khalil Ashraf E. M. , Elfarash Ameer E. , Allam Ali D. A.
Published: August 2021

Background Plant-parasitic nematodes are extremely dangerous pests in a variety of economically important crops. The purpose of this study was a survey of all nematode species existing in banana from three sites in Assiut Governorate, Egypt and to characterize the most common species by morphological, morphometric and molecular techniques (PCR with species-specific primers). Then, study of resistance or sensitivity of some banana cultivars to root-knot nematodes.Methods and Results Four nematodes, Meloidogyne, Rotylenchulus reniformis, Helicotylenchus and Pratylenchus were isolated and identified from soil and root samples collected from banana plants. Most frequently occurring of plant parasitic nematode species in banana was Meloidogyne. Former research found differences in species and in resistance to root-knot nematodes among the examined plant cultivars. Identification of Root-knot nematodes by Characterize of morphometric, molecularly, morphological isolate of Meloidogyne related to banana plants. The results revealed that the identified nematode species, Meloidogyne javanica, is the most common plant-parasitic nematodes in all locations. Data on the susceptibility of the tested banana cultivars to M. javanica revealed that Grand Naine was highly susceptible (HS) however, Magraby was susceptible (S) but Williams and Hindi cultivars were moderately resistant (MR).Conclusions we concluded that a survey revealed the significant prevalence of Meloidogyne javanica, the most important nematodes on banana in Assiut. The morphometric, morphological, and molecular identification were harmonic with one another. In addition to the host response of certain banana cultivars, to M. javanica that resistance is of significance and can be helpful to incorporate through planning control measures for root- knot nematodes.
The Effectiveness and Safety of Metronomic Chemotherapy in Patients with Head and Neck Carcinoma: A Systematic Review and Meta-analysis
Authors: Li Xingli , Wang Jianjian , Zhang Ting , Wang Jiabin , Zheng Zhangcai , Wang Cheng , Yang Lan
Published: August 2021

Background: Head and neck carcinoma, usually begins in the squamous cells, not only seriously endangers the quality of life, but brings a heavy financial burden for families and countries. Metronomic chemotherapy, a frequent administration of chemotherapeutic agents at a non-toxic dose, gives an alternative low-cost and tolerated approach for patients. We conducted a systematic review to find the effectiveness and safety of metronomic chemotherapy for head and neck cancer.Methods: We searched seven databases and Clinical.gov from the inception to July 14, 2021. The patients diagnosed head and neck cancer and older than 18 were included. Metronomic chemotherapy was defined as intervention. Randomized and non-randomized trials were all included. Quality assessment of included randomized control trials was performed using the Cochrane Risk-of-Bias criteria, cohort studies using The Newcastle-Ottawa Scale (NOS), single arm trials using the checklist recommended by The Agency for Healthcare Research and Quality (AHRQ). Studies were synthetized using a narrative approach. The indicators used for meta-analysis was hazard ratio (HR).Results: 310 Literatures were potentially eligible from 7 databases, finally 13 records were included. Five studies were of high quality, while eight were of moderate quality. The overall effect of HR for death of five trials reported had no statistically significant (HR=0.89, 95%CI 0.71-1.10). Subgroup analysis by different design showed a statistically significant HR (0.73, 95%CI 0.60-0.90) in randomized control trials while no significant difference in subgroup of prospective study design (HR=1.23, 95%CI 0.72-2.10). As for HR for PFS, there was no significant difference in overall effect of four studies. HR for PFS was 0.84 (95%CI 0.55-1.31). Subgroup analysis of study design showed that randomized control trials produced a significant HR (0.54, 95%CI 0.45-0.64), while prospective studies did not (1.25, 95%CI 0.73, 2.14).Conclusions: Metronomic chemotherapy has been an optimistic option for treatment for advanced head and neck cancer, especially in low income and medical resource-restricted regions.
Leveraging Electronic Medical Record Functionality to Capture Adenoma Detection Rate
Authors: Jones Blake , Scott Frank I. , Espinoza Jeannine , Laborde Sydney , Chambers Micah , Wani Sachin , Edmundowicz Steven , Austin Gregory , Pell Jonathan , Patel Swati G.
Published: August 2021

IntroductionMeasuring the adenoma detection rate (ADR) is critical to providing quality care, however it is also challenging. We aimed to develop a tool using pre-existing electronic health record (EHR) functions to accurately and easily measure total ADR and to provide real-time feedback for endoscopists. MethodsWe utilized the Epic® EHR. With the help of an Epic® analyst, using existing tools, we developed a method by which endoscopy staff could mark whether an adenoma was detected for a given colonoscopy. Using these responses and all colonoscopies performed by the endoscopist recorded in the EHR, ADR was calculated in a report and displayed to endoscopists within the EHR. One endoscopist piloted the tool, and results of the tool were validated against a manual chart review.ResultsOver the pilot period the endoscopist performed 145 colonoscopies, of which 78 had adenomas. The tool correctly identified 76/78 colonoscopies with an adenoma and 67/67 of colonoscopies with no adenomas (97.4% sensitivity, 100% specificity, 98% accuracy). There was no difference in ADR as determined by the tool compared to manual review (53.1% vs. 53.8%, p=0.912).ConclusionsWe successfully developed and pilot tested a tool to measure ADR using existing EHR functionality.
Preparation and Mechanical Property of Alumina Fibers Reinforced Thin Architectural Ceramic Plate
Authors: Zhong Xinzi , Cao Liyun , Huang J.F. , Liu Yijun , Ouyang Haibo , Wang Qinggang
Published: August 2021

The fibers reinforced thin architectural ceramic plate of 900 mm×1800 mm×2.5 mm with high mechanical property was prepared by a fast-sintering method with a controllable fiber dispersion process. The effects of ball-milling time to the dispersity, average length-diameter ratio and microstructure of alumina fibers were investigated respectively. Meanwhile, the alumina fiber contents to the volume density, water absorption, phase transformation and microstructure of the thin ceramic plate were researched. It is found that the two-steps ball-milling process can control the average length-diameter ratio of the alumina fibers effectively and achieve a well dispersion mixture of fibers and ceramic powders, the fast-sintering method is beneficial for the protection of fiber/matrix interface. The trend of the volume density and bending strength increases with the fiber content from 0 wt% to 5 wt% and then decreases with the fiber content from 5 wt% to 15 wt%. The bending strength of this composite reaches the maximum value of 146.8 MPa with the fiber content is 5 wt%, which is corresponding to the strengthening of alumina fibers and the formation of mullite crystallization in fiber/matrix interface and matrix during the fast-sintering process.
Genomic Markers Linked to Meloidogyne Chitwoodi Resistance Introgressed From Solanum Bulbocastanum to Cultivated Potato and Their Utilility in Marker-assisted Selection
Authors: Bali Sapinder , Brown Charles , Mojtahedi Hassan , Yilma Solomon , Ingham Russell E , Cimrhakl Launa , Quick Rich , Sathuvalli Vidyasagar
Published: August 2021

Meloidogyne chitwoodi is a major threat to potato production in the Pacific Northwest region of United States. Infected tubers are rendered unmarketable, hence growers’ profitability is adversely affected. Breeding for nematode resistance is a long-term process and phenotyping the segregating populations for nematode resistance is the most time-consuming and laborious part of the process. Using DNA-based markers closely linked to the nematode resistance trait for marker-assisted selection (MAS) could enhance breeding efficiency and accuracy. In the present study, a pool of phenotyped progenies segregating for nematode resistance and susceptibility were fingerprinted using a 21K single nucleotide polymorphism (SNP) array. Eight candidate SNPs located on potato Chromosome 11, segregating with the nematode resistance trait were identified and used as landmarks for discovery of other marker types such as, simple sequence repeat (SSR) and insertion-deletion (INDEL) markers. Subsequently, a total of eight SNPs, 30 SSRs and four INDELS located on scaffold 11 of Solanum. bulbocastanum were used to design primers; markers were validated on a panel of resistant and susceptible clones. Two SNPs (SB_MC1Chr11-PotVar0066518 and SB_MC1Chr11-PotVar0064140), five SSRs (SB_MC1Chr11-SSR04, SB_MC1Chr11-SSR08, SB_MC1Chr11-SSR10, SB_MC1Chr11-SSR13 and SB_MC1Chr11-SSR20) and one INDEL (SB_MC1Chr11-INDEL4) markers differentated between the resistant and susceptible clones in the test panel as well as other segregating progenies using simple PCR technique and high resolution melting curve analysis. These markers are robust, highly reproducible and easy to use for MAS of nematode resistant potato clones to enhance the breeding program.
The elusive magnetic ground state of sodium superoxide (NaO2)
Authors: Biswas Sarajit , De Raychaudhury Molly
Published: August 2021

An alternative energy storage solution to Li-ion batteries is a higher alkali metal superoxide, namely NaO2. It is well-known that the transport properties of this alkali superoxide are governed by the transfer of charge between O2 dimers. Although it goes through a plethora of structural phase transitions, its electronic and magnetic ground state remains shrouded. In this work, we perform first-principles density functional theory (DFT) calculations in order to understand the electronic structure, the source of the ‘unconventional’ magnetic properties and its effect on conductivity in Na superoxide. Finally, we explore the connection between magnetogyration and the magnetic ground state of NaO2 remaining undetected till date.
Rare Disease Healthcare Experience: Qualitative Survey and Workshop Findings in the Context of UK Policy Development
Authors: Jones Jennifer , Simpson Amy , Meade Nick , Pushparajah Daphnee , Newman David , Hunter Amy
Published: August 2021

Background: the UK Rare Diseases Framework is the latest policy initiative that aims to improve healthcare for rare diseases in the UK, with four priorities focussed on faster diagnosis, increasing awareness among healthcare professionals, better care coordination and improved access to specialist care and treatment. A survey of over 1,000 people living with rare diseases in the UK immediately prior to the publication of the Framework captured quantitative and qualitative data about their experiences. The qualitative analysis is presented here and compared with the content of the Framework.Results: People living with a rare condition in the UK continue to have very mixed experiences of healthcare and our findings illustrate substantial continuing unmet needs that fall under each of the four priorities of the Framework. Conclusions: Comparing the findings with what is emphasised in the Framework suggests specific key changes to policy and practice which might be missed by action plans developed under the Framework. The overall provision in the UK for people living with rare conditions needs to be improved and regularly reviewed, to ensure they are not being unfairly excluded from appropriate diagnosis, treatment or support.
Management of elderly traumatic ankle arthritis with Ilizarov External Fixation: A Retrospective Study
Authors: Li Jun , Wang Wenzhao , Yang Hai , li Bohua , Li Mingxin , Liu Lei
Published: August 2021

Objective To evaluate the clinical effect of Ilizarov external fixation and ankle arthrodesis in the treatment of elderly traumatic ankle arthritis.Methods From June 2015 to August 2019, 72 patients with elderly traumatic ankle arthritis were treated with arthrodesis through Ilizarov external fixation technique in our institution, 38 cases were males and 34 cases were females, with an average of 65.4 years (ranging from 60 to 74). Conventional double-feet loading positive and lateral X ray films were taken before operation. Angle between the tibia anatomic axis and the line segment of inside and outside of talus vertex was measured to evaluate the degree of talipes varus and valgus. Functional assessments were performed using Foot and Ankle pain score of American Orthopedics Foot and Ankle Society(AOFAS) and Visual Analogue Scale(VAS) .Results All of the patients acquired effective postoperative 18-49 months follow-up, with an average of 31.5 months. All ankles achieved bony fusion, the clinical healing time was 12.7 weeks on average(11~18 weeks).The AOFAS score was 45.36±6.43 preoperatively and 80.25±9.16 at 12 months post operation, with a statistically significant difference(P<0.0001). The VAS score was 8.56±1.85 on average preoperatively and 2.72±0.83 at 12 months post operation, with a statistically significant difference ( P<0.0001). The angle of anatomical tibial shaft and the line segment of inside and outside of talus vertex on X-ray image was 101.93°±4.12° preoperatively and 94.45°±2.37° at 12 months post operation, with a statistically significant difference(P<0.0001). The results of functional evaluation indicated that 44 patients(61.1%) had excellent results, 18 (25%) had good results, and 10 (13.9%) had fair results.Conclusion Satisfactory curative effect can be obtained through Ilizarov external fixation and ankle arthrodesis in the treatment of elderly traumatic ankle arthritis.
Effect of Mn On The Performance and Mechanism of Catalysts For The Synthesis of (Ce,La)CO3F
Authors: Li Na , Chen Zedong , Hou Liming , Jiao Kunling , WU Wenfei
Published: August 2021

In accordance with the cerium-lanthanum ratio of fluorocerium ores in the mineralogy of the Baiyun Ebo process, pure substances such as Ce(NO3)3·6H2O, La(NO3)3·6H2O were used to synthesize (Ce,La)CO3F grains to simulate bastnaesite minerals by hydrothermal method, and used as NH3-SCR denitrification catalysts. After being roasted at a series of different temperatures, the catalyst surface produced a well-crystallised Ce7O12 species as the active component for denitrification. The activity results showed that the synthetic (Ce,La)CO3F was roasted at 500°C, and the NOx conversion was 27% at 200°C. The NH3-SCR catalytic activity of the synthesised (Ce,La)CO3F was improved by loaded transition metal Mn. The best catalyst was found to be produced by impregnating (Ce,La)CO3F with 1 mol/L manganese nitrate solution, with a NOx conversion of 80% at 250°C. The physicochemical properties were analysed using XRD, BET, H2-TPR, NH3-TPD and XPS. The loading of Mn resulted in the appearance of numerous well-dispersed MnOx species on the catalyst surface, the dispersion of Ce7O12 species was also greatly enhanced, and the reduction in grain size indicated that Mnn+ entered into the (Ce,La)CO3F lattice causing lattice shrinkage. The number of acidic sites on the catalyst surface and the redox capacity were enhanced. The amount of Ce3+ in the catalyst was also enhanced by the introduction of Mnn+, but the proportion of adsorbed oxygen decreased, which indicated that the introduction of Mnn+ was detrimental to the increase in the proportion of adsorbed oxygen. The reaction mechanisms of the (Ce,La)CO3F and Mn/(Ce,La)CO3F catalysts were investigated by in-situ Fourier transform infrared spectroscopy (FTIR), to provide theoretical guidance for the specific reaction pathways of bastnaesite in the NH3-SCR reaction. The results showed that catalysts followed both the E-R and L-H mechanisms throughout the reaction process. When loaded with Mn, the main reactive species in the L-H mechanism were the NH4+(ad) species on the Brønsted acidic site and the O-Ce3+-O-NO, O-Mn3+-O-NO species. The main reactive species for the E-R mechanism were NH3/NH4+(ad) species on the Brønsted/Lewis acidic sites and NO. The NH4+ (ad) species on the Brønsted acidic sites act as the main reactive NH3(g) adsorbing species, bonded to the Ce4+ in the carrier (Ce,La)CO3F to participate in the acid cycle reaction. The introduction of Mnn+ increases the number of Brønsted acidic sites on the catalyst surface, and acts as an adsorption site for NO, to react with NO to generate more monodentate nitrate species, to participate in the redox cycle reactions. The above results indicated that Mnn+ and (Ce,La)CO3F have a good mutual promotion effect, which makes the loaded catalyst have excellent performance, which provides a theoretical basis for the high value utilization of bastnaesite.
Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats
Authors: Palacios José L. , Juárez Ricardo , Mirto-Aguilar Nancy , Munoz Alvaro , Damaser Margot S. , Cruz Yolanda
Published: August 2021

The aims of the study were to determine the time-course of urinary incontinence recovery after vaginal distension (VD), elucidate the mechanisms of injury from VD leading to external urethral sphincter (EUS) dysfunction, and assess if transcutaneous electrical stimulation (TENS) of the dorsal nerve of the clitoris facilitates recovery of urinary continence after VD. Rats underwent 4-h VD, 4-h sham VD (SH-VD), VD plus 1-h DNC TENS, and VD plus 1-h sham TENS (SH-TENS). TENS or SH-TENS were applied immediately and at days 2 and 4 post-VD. Micturition behavior, urethral histochemistry and histology, EUS and nerve electrophysiology, and cystometrograms were evaluated. VD induced urine leakage and disrupted EUS fibers and nerve-conduction. Urine leakage disappeared 13 days post-VD. Structural and functional recovery of the EUS neuromuscular circuitry started by day 6 post-VD but did not fully recovered by day 11 post-VD. TENS significantly decreased the frequency of urine leakage post-VD (p<0.01). We conclude that rat urinary continence function after VD requires 2 weeks to recover, although urethra structure is not fully recovered. Treatment to facilitate neuroregeneration should be applied within one-week after damage. TENS facilitated urinary continence recovery after VD. This treatment may have potential to decrease postpartum urinary incontinence in women.
Incidence of Transfusion-Related Acute Lung Injury Temporally Associated With Solvent/Detergent Plasma Use In The ICU - A Retrospective Before and After Implementation Study
Authors: Klanderman Robert , Mourik Niels van , Eggermont Dorus , Peters Anna-Linda , Tuinman Pieter-Roel , Bosman Rob , Endeman Hendrik , Cremer Olaf L. , Arbous Sesmu M , Vlaar Alexander P.J.
Published: August 2021

Background: Transfusion-related acute lung injury (TRALI) is a severe complication of plasma transfusion, though use of solvent/detergent pooled plasma (SDP) has nearly eliminated reported TRALI cases. The goal of this study was to investigate TRALI incidence in the intensive care unit (ICU) following replacement of quarantined, male-only, fresh frozen plasma (qFFP) by SDP for routine use. Methods:We conducted a retrospective multicenter observational before-after cohort study during two six-month periods, before (April to October 2014) and after introduction of SDP (April to October 2015), taking into account a six-month wash-out period. One secondary and four tertiary academic hospitals participated.Results:Admitted to the ICU were 8944 patients during both inclusion periods. 1171 qFFP units were transfused in 376 patients in the qFFP, and 396 during the before and after periods respectively in the SDP period. A full patient chart review was performed in 300 patients that received ≥1 units of plasma and had a PaO2/FiO2-ratio (P/F-ratio) <300 within 24 hours. Ten cases of TRALI occurred during the qFFP and nine cases during the SDP period, in which plasma was transfused concomitantly with other products, or alone. The incidence was 0.85% (CI95%: 0.33% – 1.4%) per unit qFFP and 0.45% (CI95%: 0.21% - 0.79%, p = 0.221) per SDP-unit. One instance of TRALI occurring after a single SDP unit. Mortality was 70% for patients developing TRALI in the ICU compared to 22% in all patients receiving at least one plasma transfusion. Conclusion:Implementation of SDP lowered the incidence of TRALI in which plasma products were implicated, though not significantly. TRALI can still occur as a result of SDP transfusion. Developing TRALI in the ICU was associated with high mortality rates, therefore clinicians should remain vigilant.