bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal associations between sex hormone-binding globulin and insulin resistance
Authors: Ottarsdottir Kristin , Hellgren Margareta , Bock David , Nilsson Anna G , Daka Bledar
Published: April 2020

Purpose

We aimed to investigate the association between SHBG and the homeostatic model assessment of insulin resistance (HOMA-Ir) in men and women in a prospective observational study.

Methods

The Vara-Skövde cohort is a random population of 2816 participants living in southwestern Sweden, aged 30–74. It was recruited between 2002 and 2005, and followed up in 2012–2014. After excluding participants on insulin therapy or hormone replacement therapy, 1193 individuals (649 men, 544 women) were included in the present study. Fasting blood samples were collected at both visits and stored in biobank. All participants were physically examined by a trained nurse. SHBG was measured with immunoassay technique. Linear regressions were computed to investigate the association between SHBG and HOMA-Ir both in cross-sectional and longitudinal analyses, adjusting for confounding factors.

Results

The mean follow-up time was 9.7 ± 1.4 years. Concentrations of SHBG were significantly inversely associated with log transformed HOMA-Ir in all groups with estimated standardized slopes (95% CI): men: −0.20 (−0.3;−0.1), premenopausal women: −0.26 (−0.4;−0.2), postmenopausal women: −0.13 (−0.3;−0.0) at visit 1. At visit 2 the results were similar. When comparing the groups, a statistically significant difference was found between men and post-menopausal women (0.12 (0.0;0.2) P value = 0.04). In the fully adjusted model, SHBG at visit 1 was also associated with HOMA-Ir at visit 2, and the estimated slopes were −0.16 (−0.2;−0.1), −0.16 (−0.3;−0.1) and −0.07 (−0.2;0.0) for men, premenopausal and postmenopausal women, respectively.

Main conclusion

Levels of SHBG predicted the development of insulin resistance in both men and women, regardless of menopausal state.
Birth of offspring from spermatid or somatic cell by co-injection of PLCζ-cRNA
Authors: Hirose Naoki , Wakayama Sayaka , Inoue Rei , Ito Junya , Ooga Masatoshi , Wakayama Teruhiko
Published: April 2020

Artificial oocyte activation is important for assisted reproductive technologies, such as fertilization with round spermatids (ROSI) or the production of cloned offspring by somatic cell nuclear transfer (SCNT). Recently, phospholipase Cζ (PLCζ)-cRNA was used to mimic the natural process of fertilization, but this method required the serial injection of PLCζ-cRNA and was found to cause damage to the manipulated oocytes. Here we tried to generate offspring derived from oocytes that were fertilized using round spermatid or somatic cell nuclear transfer with the co-injection of PLCζ-cRNA. After co-injecting round spermatids and 20 ng/µL of PLCζ-cRNA into the oocytes, most of them became activated, but the activation process was delayed by more than 1 h. With the co-injection method, the rate of blastocyst formation in ROSI embryos was higher (64%) compared with that of the serial injection method (55%). On another note, when SCNT was performed using the co-injection method, the cloned offspring were obtained with a higher success rate compared with the serial-injection method. However, in either ROSI or SCNT embryos, the birth rate of offspring via the co-injection method was similar to the Sr activation method. The epigenetic status of ROSI and SCNT zygotes that was examined showed no significant difference among all activation methods. The results indicated that although the PLCζ-cRNA co-injection method did not improve the production rate of offspring, this method simplified oocyte activation with less damage, and with accurate activation time in individual oocytes, it can be useful for the basic study of oocyte activation and development.
Provocation as a Genre: Rhetorical Definitions of MeToo Discourse
Authors: Gabrėnaitė Eglė , Triaušytė Monika
Published: April 2020

Modern media has led to changes in the scope, intensity and effectiveness of communication. The Internet medium, which offers almost unlimited dialogue and polylogue possibilities, has become an attractive place for provocation to be born and function. The provocative narrative not only inspires these processes, but also becomes as a result of such a genre modification. This article analyzes a provocative discourse, the Lithuanian version of the global movement MeToo, which promotes the publication of cases of sexual harassment: testimonies of women who have been sexually harassed, publications in the media discussing the issue, interviews with discourse participants, another type of comments. The MeToo discourse is characterized by a rhetorical aspect: the concept of provocation as an effective communication strategy is explored; the relationship of the provocative narrative to the genre category is discussed; characteristic rhetorical elements – invention, disposition, elocution – have been distinguished.
Oral Narrative Genres as Communicative Dialogic Resources and their Correlation to African Short Fiction
Authors: Huber Loreta , Jonaitytė Evelina
Published: April 2020

Oral and written storytelling traditions in Africa developed at the same time and influenced each other in many ways. In the twentieth century, the relation between the deeply rooted oral tradition and literary traditions intensified.We aim to reveal literary analysis tools that help to trace ways how oral narrative genres found reflection in African short fiction under analysis. A case study is based on two short stories by women writers, The Rain Came by Grace Ogot and The Lovers by Bessie Head. Images and symbols both, in oral and written traditions in Africa, as well as the way they evolved and extended in a literary genre of short fiction are considered within the framework of hermeneutics, reader reception theory and feminist literary criticism.The results obtained in the study prove that oral narrative genres interact with literary genres, though most importantly, women’s writing as a literary category and images embodied in the short stories play a decisive role and deviation from the images embodied in African oral tradition.
Spatiality of the City in Literature: Possibilities and Limits of the Semiotic Approach
Authors: Kundrotaitė Aušra
Published: April 2020

The article attempts to delineate adequate ways of thinking about the spatiality of the city in literature. It examines two semiotic approaches to the problematic of the city, namely Jurij Lotman’s semiotics of culture and Algirdas Julius Greimas’ urban semiotics, and their applicability to the analysis of its literary representation. Lotman’s concept of semiosphere is invoked to outline the complex, two-way relationship between consciousness and the city. Highlighting the communicative and autocommunication processes of culture helps to establish a link with Greimas’ interpretive and generative methodological approaches. Both Greimas and Lotman treat the city as a virtual reality concentrating on the ideological, symbolical and philosophical aspects of it. Their theories regard language primarily as an acoustic phenomenon (as speech), and consequently tend to disregard its visual (e. g. graphic) features. The article considers possible combinations of the different branches of semiotics. The special attention is focused on demonstrating the importance of the (inter)medial aspects of the literary representation. A case study of the photo-essay helps to expose similarities and differences of the semiotic and the intermedial approaches. The article demonstrates how recognizing specific (inter)medial aspects of the text allows regarding the literary city as a topological object.
The Genre Conference Brought Together Scholars from Different Fields
Authors: Bankauskaitė Gabija
Published: April 2020

Spalio 11 dieną Vilniaus universiteto Kauno fakulteto Kalbų, literatūros ir vertimo studijų institute įvyko tarpdalykinė mokslinė Žanro konferencija. Renginio dalyves sveikino konferencijos sumanytoja ir mokslinio komiteto pirmininkė profesorė Gabija Bankauskaitė.
Preclinical simulation courses in dental education with COVID-19 pandemic
Authors: Durán Ojeda Gerardo
Published: April 2020

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Intellectual Genealogy of Tuan Guru H.M Said Amin Bima (1936-2015)
Authors: Mutawali Muhammad , Murtadha Rahmah , Fata Ahmad Khoirul
Published: April 2020

The study on the Ulama in the Eastern Part of Indonesia, especially Bima and its surrounding area was scarcely limited, especially related to the Ulama Network in Nusantara during the XVIII-XX centuries. This study is expected to not only contribute to this lack of knowledge about the subject but also to pave a way for sustainable study on the network of Ulama from Bima in Nusantara. This paper will investigate one of the Ulama or Tuan Guru who lived in the XX century, which was the last generation of Ulama from Bima’s involvement in the Ulama Network of Nusantara, called Tuan Guru H. M. Said Amin. This study is focused on the intellectuality chain hence, its correlation with the Ulama Network of Nusantara can be found and this paper is concluded with several of his thoughts in Islamic law.
The Concepts of Nosarara Nosabatutu in the Kaili Community : Inspiration for Religious Harmony in Indonesia
Authors: Septiwiharti Dwi , Maharani Septiana Dwiputri , Mustansyir Rizal
Published: April 2020

This article aims to describe the local wisdom and values of Nosarara Nosabatutu in the Kaili community in Central Sulawesi using an axiological perspective as an inspiration for religious harmony in Indonesia. This research employs a qualitative method in the field of philosophical axiology. The object of research material is the teaching of nosarara nosabatutu, and the formal object is the theory of objectivism of values. The analysis shows that family values are at the vital value level, while the value of unity is at the spiritual value level in the Schelerian hierarchy. Both values indicate spiritual sentiments and spiritual preferences. Nosarara teaches individuals to love others as their brothers, as reflected Kaili’s term of sararata le or sararata ia which means s/he is a family. Spiritual nosabatutu teaches one to take care of the family property as shared wealth and also keep other people's secrets because everyone in the Kaili ethnic group comes from the same womb and lives from the same treasure as a family.
Biohacking Phenomenon in the Context of Essentialist and Constructivist Conceptions of Science
Authors: Petrov Kirill
Published: April 2020

The problem of demarcation of science from non-science presupposes the existence of two principal approaches: essentialism and constructivism. Not exhausting all the variety of analytical concepts, they set the basic framework for the study of this issue for social theory. The Central principle of essentialism is the assertion of the existence of a substantial "core", which sets the unique features of science. The General position of constructivism in solving the problem of demarcation can be recognized as a denial of the existence of an invariable basis of scientific activity, science is determined by a variety of "external" factors and claimed as contingent to a variety of social phenomenas. The fundamental principle of constructivism assumes the "emptiness of science" – pure space waiting for limitation and filling. The basic intuition of constructivism in relation to science is very fruitful for social theory, directing the attention of the researcher on practices associated with the reproduction of the boundaries of science / non-science, what Thomas F. Gieryn summarized in the concept of boundary-work. Depending on the cultural, economic or political context, the demarcation line is constantly redrawn. The last major clashes on the science / non-science frontier include the radical transformations of biology. It is impossible to imagine the development of biology in the second half of the twentieth century without the active use of mathematical methods and information technology. The use of open data and computer methods of working with information, coupled with open access and democratic principles of dissemination of information led not only to a change in disciplinary boundaries, but also served as an impetus for the formation of independent groups of "researchers", science enthusiasts – biohackers. Their activities, reproducing the formal principles of science, but carried out independently of the "official" science – another example of "boundary work". At the same time, neither essentialist nor constructivist theories are able to understand biohacking within their theoretical frameworks. Social research of biohackers allows to see better the basic principles of practice of building of boundary between science and nonscience and to understand the restrictions connected with application of the concept "boundary-work".
Life-World of Metropolis: Specifics of Gender Perception
Authors: Ilynykh Svetlana
Published: April 2020

The article discusses the view of a metropolis, due to the formation of metropolis identity. This identity is associated with a complex of sociocultural, socio-psychological processes, including the process of socialization in a big city. In a metropolis, patriarchal stereotypes are manifested to a lesser extent than in small cities, which contribute to a more rigid consolidation of gender roles. There is a smoothing of the gender aspects of consciousness. This situation is due to the fact that, on the one hand, the socialization of residents of megacities, as well as residents of other territories, occurs within the framework of gender culture. But, on the other hand, residents of megacities in everyday life are much more likely to encounter practices that go beyond the framework of the traditional socio-gender system. The paper provides empirical examples illustrating the characteristics of a metropolitan identity. Gender smoothing is taking place when evaluating the activities of educational and cultural institutions. Approximately equal shares of men and women assess the activities of educational and cultural institutions as high-level work. The low -level work of educational and cultural institutions is also estimated by men and women in approximately equal proportions. The results of the study show that men living in megacities stand in solidarity with women in their assessments. This may indicate that men and women are equally involved in raising children, which reflects the process of smoothing out gender stereotypes. No gender differences were also found when studying respondents' assessments of certain aspects of the social sphere. It is shown that the gender aspects of consciousness remain when assessing the sphere of health care. Significant differences in assessments of health care institutions exist when studying the question of satisfaction with the quality of state medical services, the availability of medical care and the work of ambulances. It is concluded that the smoothing of the gender aspects of consciousness is caused not only by personal characteristics but also by the individual living in a big city.
Head Gesture Recognition using a 6DOF Inertial IMU
Authors: Severin Ionut Cristian , Dobrea Dan Marius , Dobrea Monica Claudia
Published: April 2020

The recognition of the head movements is a challenging task in the Human-Computer Interface domain. The medical, automotive, or computer games domains are only several fields where this task can find practical applicabilities. Currently, the head movement recognition is performed using complex systems based on video information or using an IMU sensor with nine freedom degrees. In this paper, we describe a new approach for recognizing head movements using a new type of IMU sensor with six freedom degrees placed on top of a headphone pair. The system aims to provide an easy control method for people suffering from tetraplegia for a specific set of activities. The system collects data from the inertial sensor placed on top of the headphone to analyze and then extract the features for head movement recognition. We did construct and evaluated eight predictive models of classifying head movements activity to determine which one is the best fit for the proposed head movement recognition system. The comparison and performance evaluation provided by each predictive model lead to demonstrate the performances delivered by our new system for head movements recognition.
Revolution und noch kein Ende
Authors: Pinkard Terry
Published: April 2020

Manchmal scheint es, als nehme die Welt ihren gewohnten Lauf und die Zukunft sei linear aus den bestehenden Tendenzen abzuleiten. Plötzlich aber setzen unvorhergesehene Ereignisse alle möglichen Veränderungen in Gang, und die vertrauten Tendenzen wirken überholt. Ein paradigmatischer Fall dafür sind Revolutionen. An einem Tag meint man noch, die alten Machthaber hielten das Heft fest in der Hand, am nächsten Tag sind sie verschwunden. Natürlich kann es auch passieren, dass sich die sicher geglaubten Errungenschaften der Revolution plötzlich in Luft auflösen und die alte Ordnung an die Macht zurückkehrt.
Zum Thema
Authors: Breckman Warren , Hacke Jens , Matthiesen Michael
Published: April 2020

«Keiner hat mich verstanden, außer einem, und der hat mich missverstanden», soll Hegel auf dem Sterbebett geklagt haben. Über die Verständlichkeit der Hegelschen Vorlesungen waren auch schon seine Hörer unterschiedlicher Auffassung. Die einen mokierten sich über die schwäbische Mundart, die nächsten fanden seinen klappernden Stil verquast, andere monierten seine Unfähigkeit zum freien Vortrag. Auch die spielerischen Formen des Geistes, die ironische Relativierung oder die humoristische Seitenbemerkung, wie man sie bei Kant findet, waren eher Fehlanzeige.
Der Nachlass und die verlorenen Briefe
Authors: Overgaauw Eef , Matthiesen Michael
Published: April 2020

Hegel starb 1831 in Berlin. Ob er seine Vorlesungsmanuskripte, die handschriftlichen Vorarbeiten zu seinen Werken, die an ihn gerichteten Briefe, die Entwürfe und Abschriften seiner eigenen Briefe und weitere handschriftliche Materialien zu seinen Lebzeiten geordnet hat, wissen wir nicht. Wir wissen auch nicht, ob Hegel sich zu seinen Lebzeiten Gedanken über den künftigen Verbleib seiner Papiere gemacht hat. Anders als heute, gab es im 19.Jahrhundert kaum Vorlässe. Hegels Nachlass blieb somit zunächst in der Obhut der Erben, zunächst bei der Witwe Marie (1791–1855), danach bei den Söhnen Karl (1813–1901) und Immanuel (1814–1891). Sie hielten den Nachlass nicht unter Verschluss, sondern stellten einzelne Manuskripte wiederholt für Veröffentlichungen einzelner Hegel-Forscher zur Verfügung. So behielten die Erben die Kontrolle über das schriftliche Vermächtnis ihres verstorbenen Ehemannes oder Vaters.
Bench top CUT&Tag v1
Authors: S Kaya-Okur Hatice , Henikoff Steven
Published: April 2020

Here we describe a bench top protocol for Cleavage Under Targets and Tagmentation (CUT&Tag), an enzyme-tethering strategy that provides efficient high-resolution sequencing libraries for profiling diverse chromatin components. In CUT&Tag, a chromatin protein is bound in situ by a specific antibody, which then tethers a proteinA-Tn5 transposase fusion protein. Activation of the transposase efficiently generates fragment libraries with high resolution and exceptionally low background. All steps from live cells to sequencing-ready libraries can be performed in one day. We have demonstrated the utility of CUT&Tag by profiling histone modifications, RNA Polymerase II and transcription factors on low cell numbers and single cells. Version 3 includes an optional light formaldehyde treatment of cells or nuclei prior to antibody addition. Light fixation reduces the tendency of cells or nuclei to clump, which can also be reduced for fixed and unfixed nuclei by omitting digitonin from all steps.
Distribution characteristics and influencing factors of central sleep apnea in pediatric patients with obstructive sleep apnea disorder (OSAD): a single-center study v2
Authors: Chang Li , Liu Jing , Cao Ling , Huang Guimin
Published: April 2020

Objective: To elucidate the distribution characteristics and major factors associated with central apnea (CA) in pediatricobstructive sleep apnea disorder (OSAD). Methods: A retrospective chart review of polysomnographic (PSG) data of children diagnosed with OSAD from January 2017 to March 2018 was performed. Differences in demographic and sleep parameters were compared among mild, moderate and severe OSAD groups. The distribution characteristics of CA were analyzed, and influencing factors of CA were determined. Results: 856 children were involved, including 317 girls and 539 boys; the average age was 4.9±2.4 years. The moderate and severe groups had a higher central apnea index (CAI), and the severe group had a shorter rapid eye movement (REM) period. 50.1% (429/856) had a CAI >1, and 2.9% (25/856) had a CAI >5. Children with a CAI >1 had a higher obstructive apnea hypopnea index (OAHI) (p<0.001), oxygen desaturation index (ODI) (p<0.001) and a longer REM period (p<0.001) but a younger age (p<0.001) and a shorter slow-wave sleep (SWS) phase (p=0.016) than children with a CAI ≤1. Multivariate binary logistic regression showed that with an increased REM period, the risk of the CAI being >1 increased 181 times (OR=181.846, 95% CI: 22.777~1451.802, p＜0.001). The CAI increased with an increasing OAHI (OR=1.023, 95% CI: 1.008~1.039, p=0.003). The possibility of a CAI ≤1 increased with age (OR=0.836,95% CI: 0.786~0.890, p＜0.001), and boys were more likely to have a CAI ≤1 than girls (OR=0.609, 95% CI: 0.455~0.816, p=0.001). Conclusions: In addition to obstructive apnea (OA), almost all children with OSAD also had CA. A CAI >1 was most likely to occur in children with OSAD, but a CAI >5 and OSAD rarely coexisted in children. The OAHI and REM period were risk factors for an increased CAI, and age and male sex were protective factors.
Total Personal Quality of University Students in Medan, Indonesia
Authors: Sitanggang Nathanael , Luthan Putri Lynna A. , K. Abdul Hamid
Published: April 2020

The research aims to study the students' personal total quality at universities in Medan, Indonesia. The research method is a survey at four universities in Medan namely the State University of Medan, North Sumatra Muhammadiyah University, HKBP Nommensen, and the Islamic University of North Sumatra. The respondents amounted to 380 students who have been determined proportionally through random sampling. The research instrument was a questionnaire with a reliability coefficient of 0.82. Results of the study found that 31.05% variable quality of students belong to the category of the personal total which is very high and 67.37% belong to a high category. However, there is 1:58% total quality of students classified categorized as low. The results were found to give instructions to the universities to keep working to improve students' personal total quality as the individual characteristics. The individual characteristics of students are very important to note the whether the increase due to the individual characteristics affects work motivation, performance, career development, and job satisfaction.
The Possibilities of Empathy in Preventing Interpersonal Conflicts in the Educational Environment of a Higher Education Institution
Authors: Smolyaninova Olga G. , Posokhova Svetlana T. , Izotova Margarita Kh.
Published: April 2020

The present article studies the possibilities of empathy in preventing interpersonal conflicts in the sphere of higher education. Interpersonal conflicts are regarded from the sociopedagogical perspective as a complex phenomenon, the emergence and development of which is predetermined by the personal features of the participants of the education process. The success of mediation in a conflict between learners is determined by the knowledge of factors that decrease the probability of a conflict situation. Empathy is one of the personal features that may be employed to prevent conflict situations and to expand the range of applicable mediation technologies. The empirical study was carried out with students majoring in psychology, medicine and technical science aged from 18 to 24. The empathy level diagnostic questionnaires by V.V. Boyko and A. Megrabian were used. It was found that the psychology students feature the best developed empathy. Empathy brings the learners together, cuts down aggressive tendencies, blocks competitive attitude towards students with special needs. Empathy develops the fundamental neutral relations between conflicting parties, which is essential to prevent interpersonal conflicts. A conclusion on the importance of developing empathic capacity of the students majoring in mediation is made

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SPECULATIVE GROWTH OF CONSERVATION NARRATIVES
Authors: Mannisi Alban
Published: April 2020

As culture appears in governmental policy when its disappearance starts, heritage becomes a concern when its local meaning vanishes. Moreover, globalization usually reveals the ignorance on the cultural legacy accelerated by its instrumentalised branding. Moreover, this vision of economic trade fails to resolve these issues of intangible heritage. Above all, since there is no future without past, like the sustainability of environment, and that cities and territories of the Silk Road territories are defined by a good cohesion of these entities, the current critical issues are the establishment of good balances between the global world and the local heritage. Thus, the transverse degeneration of these geographical roots, territorial strategies, social management, and economic exchanges of the various globalizations seems exceptionally fragile in the 21st century. To the point that these counterexamples are now refused by responsible citizen movements considering such models of urban expansions that capitalistic corruption reigns over as the figures of ontological aberrations. To illustrate these phenomena in the Asian region, the following study takes three cases directly investigated on site: Japan as the symbol and symptom of the introduction of exogenous philosophy and practice which have altered its nature / culture relations of the 19th century to the point to entirely return to its indigenous environmental ethics; now stabilized, exports and reproduces the same errors in the heart of countries undergoing the similar drifts as rural Australasia. The state Island of Singapore, rich of a multi-ethnic community evolving in a neoliberal socialism, combines the ontologies that move each society to develop its territory from culturally appropriate practices to the pressures of a standardized educational system. This paradoxically leads its experts towards a universality of cultural landscapes posing the problem of urban and landscape alienation to unique market aims. The rowdy reinvention of the traditions devoted to the western hegemonic submission has profoundly damaged the cultural identity of South Koreas urban, natural, and social environment. Example of exogenous diktats on fragile autochthonous practices by a corporate malpractice, South Korea raises the question of political governance and ecosophical resistances always ignored in globalization aims. From these three cases of territorial governance, we will consider what can be the sustainable growth and preservation policies within the vast Silk Road spaces.
Control of a reservoir partially filled with liquid based on Gauss's principle of least constraint (deceleration task)
Authors: Konstantinov O. V.
Published: April 2020

The task of constructing control for the motion of a given reservoir - a liquid with a free surface mechanical system is provided in the presence of constant perturbations - the oscillations of the free surface of the liquid. To construct the control, the principle of the least coaxing of Gauss was used, which allows to minimize the control load and implement the given laws of the software movement. The control calculation was carried out on the basis of a simplified linear model with two degrees of freedom, which allowed the control function to be obtained in analytical form for various software laws (including nonlinear) movement of the reservoir and free surface of the liquid. The tank partially filled with a liquid, which initially moves evenly at a given speed, must be completely stopped at a given time. The control, constructed for the implementation of linear software laws of motion, can be used only to provide "comfortable" movements of the reservoir, that is, in the absence of large disturbances of the free surface of the liquid. In order to ensure the movement of the reservoir in the presence of highly intense loads, it is necessary to introduce nonlinear software motion laws for obtaining and using a nonlinear control law.
Analytical model of deformation of flange with concatenated shell under internal pressure
Authors: Kutsenko O. G. , Kharytonov O. M. , Kharytonova L. V.
Published: April 2020

The rings torsion theory that is based on the assumption about flat rigid cross-section was suggested by the authors in the previous papers. The analytical expressions of torsional stiffness have been derived for different kind of loads: pure moment, shear force and surface pressure. In the present paper the analytical model of flange with attached cylindrical shell deforming under internal pressure is suggested. The mechanical system is split into two parts (flange and shell) with the help of imaginary section method. An unknown shear force and bending moments are applied to both parts according to this method. Therefore flange is loaded under internal pressure, shear force and bending moments. As mentioned above, for all these loads the angle of flange cross-section rotation can be presented in analytical form based on the rings torsion theory. Full rotation angle is presented as a sum of these angles. The radial displacement of imaginary section was determined on the basis of the assumption about flat rigid cross-section. On another hand, the rotation angle and radial displacement of imaginary section are determined on the base of the cylindrical shell bending theory too. Two linear equations in the unknown shear force and bending moment were derived by equating corresponding expressions. In such а way the analytical model of flange with attached shell deforming was built. The comparison calculations by finite element methods confirmed the adequacy of proposed model.
Methods of calculating the deflection of an orthotropic inhomogeneous plate on an elastic basis
Authors: Lavrenyuk M. V.
Published: April 2020

The problem of elastic equilibrium of an orthotropic nonhomogeneous rectangular plate on an elastic basis (one-parameter Winkler model) is considered, hingedly fixed from all sides. We use the Navier method for finding the deflection function at each step of the iterative process and perturbation methods and successive approximations as iterative methods for solving the problem. The suitability of the method of successive approximations and the method of perturbations for the numerical solution of the problem of determining the stress-strain state of such a plate, the limits of the applicability of these methods, their accuracy and convergence of the iterative process in solving the deformation problems of heterogeneous orthotropic plates have been analyzed.

The dependence of the deflection on the mechanical and geometric parameters of the plate and the base is established. It was found that the Poisson ratio practically does not affect the stress state of the plate (when the Poisson ratio is changed two times, the difference between the intensities of the shear stresses does not exceed 10%), it is possible to consider it as a constant using the methods of successive approximations and disturbances. It is also established that the method of successive approximations and the method of perturbations has a limit on the nature of inhomogeneity, the convergence essentially depends on the nature of the heterogeneity.
Consideration of wear in plane contact of rectangular punch and elastic half-plane
Authors: Onyshkevych V. M. , Sulym G. T.
Published: April 2020

The plane contact problem on wear of elastic half-plane by a rigid punch has been considered. The punch moves with constant velocity. Arising thermal effects are neglected because the problem is investigated in stationary statement. In this case the crumpling of the nonhomogeneities of the surfaces and abrasion of half-plane take place. Out of the punch the surface of half-plane is free of load. The solution for problem of theory of elasticity is constructed by means of Fourier integral transformation. Contact stresses are found in Fourier series which coefficients satisfy the dual integral equations. It leads to the system of nonlinear algebraical equations for unknown coefficients by a method of collocations. This system is reduced to linear system in the partial most interesting cases for computing of maximum and minimum wear. The iterative scheme is considered for investigation of other nonlinear cases, for initial approximation the mean value of boundary cases is used. The evolutions of contact stresses, wear and abrasion in the time are given. For both last cases increase or invariable of vertical displacement correspondently is obtained. In the boundary cases coincidence of results with known is obtained.
Thermomechanical problem on vibration of a viscoelastic rubberlike rod under dynamic loading
Authors: Ostos O. J. , Zhuk Y. A.
Published: April 2020

The problem on vibration of a viscoelastic rod under dynamic load at one of its ends is considered. The external loading has a signfficant influence on the dynamic characteristics of the material. By using the complex moduli, the problem on vibration of the viscoelastic rod was solved. The complex shear and Young's moduli of a rubberlike material should exhibit the same dependence on frequency. The properties of a rubberlike material was applied. The temperature influence is associated both with the Newton boundary conditions and dissipative heating. The dissipative function is expressed in terms of deformations. The frequencies of high-damping materials occur at or near frequencies that are normally of interest in vibration problems at room temperature. For solving the problem a finite element model was applied. Using this model, qualitative analysis of the influence of dynamic load and dissipative heating on the resonant vibrations of viscoelastic rod is performed. According to the theory of viscoelasticity an analysis of the results was done. The reliability of the values of frequencies for the first resonances was checked. The numerical results qf the problem on vibration of a viscoelastic cylindrical rod under dynamic load at one of its end by the general thermomechanical laws on vibration in damped mechanical systems were obtained and investigated. Distribution of the temperature of dissipative heating along the rod axis is analyzed.
Creep of isotropic homogeneous and nonaging of linear-viscoelastic materials under the complex stress state
Authors: Pavlyuk Y. V.
Published: April 2020

The relaxation of isotropic homogeneous and non-aging linear-viscoelastic materials under conditions of complex stress state is considered. Thin-walled tubular specimens of High Density Polyethylene (HDPE) for creep under a single-axial stretching, with a pure twist and combined load tension and torsion are considered as base experiments, tests. The solution is obtained by generalizing the initial one-dimensional viscoelasticity model to a complex stressed state, constructed using the hypothesis of the proportionality of deviators. The heredity kernels are given by the Rabotnov’s fractional-exponential function. The dependence between the kernels of intensity and volumetric creep is established, which determine the scalar properties of linear viscoelastic materials in the conditions of a complex stressed state in the defining equations of the type of equations of small elastic-plastic deformations, and the kernels of longitudinal and transverse creep defining the hereditary properties of linear-viscoelastic materials under the conditions of the uniaxial tension. The problems of stress relaxation calculation of thin walled tubes under combined tension with torsion have been solved and experimentally approved.
Steady-state resonant sloshing in upright cylindrical tank due to elliptical forcing
Authors: Raynovskyy I. A.
Published: April 2020

The nonlinear Narimanov-Moiseev multimodal equations are used to study the swirling-type resonant sloshing in a circular base container occurring due to an orbital (rotary) tank motion in the horizontal plane with the forcing frequency close to the lowest natural sloshing frequency. These equations are equipped with linear damping terms associated with the logarithmic decrements of the natural sloshing modes. The surface tension is neglected. An asymptotic steady-state solution is constructed and the response amplitude curves are analyzed to prove their hard-spring type behavior for the finite liquid depth (the mean liquid depth-to-the-radius ratio h>1). For the orbital forcing only swirling occurs. This behavior type is supported by the existing experimental data. Phase lags, which are piecewise functions along the continuous amplitude response curves in the undamped case, become of the non-constant character when the damping matters. The wave elevations at the vertical wall are satisfactory predicted except for a frequency range where the model test observations reported wave breaking and/or mean rotational flows.
On some method of the heredity kernel parameters determination of nonlinear viscoelastic materials under the complex stress state
Authors: Reznik V. S.
Published: April 2020

The deformation of viscoelastic medium given by means of constitutive equations of the hereditary type. These equations establish the relationship between the components of strain tensor, the components of stress tensor and the integral time operator, and contain the set of function and coefficients that are determined from the basic experiments. А method of the heredity kernel parameters determination of nonlinear viscoelastic materials is developed. As the visco-elastic model, the constitutive equations of the hereditary type are chosen in which the relationship between the components of the strain tensor and the stress tensor is given based on the hypothesis of the deviators proportionality. The nonlinearity of the viscoelastic properties is given by the equations of Ratotnov’s type. The method is based on the relations between the creep kernels under complex stress state and the creep kernels under one-dimensional stress state. The method verified experimentally for the problems of determination of creep deformations under combined loading applied to the thin-walled tubular elements made of polyethylene of high density.
CONTRADICTIONS OF TACTICAL AND STRATEGIC DECISIONS IN BUSINESS DEVELOPMENT
Authors: Tebekin A. V. , Metropolitan-Rodionova N. V. , Horeva A. V.
Published: April 2020

The expected consequences of the Government's decision to temporarily ban imports of petroleum products from abroad are analyzed from a macroeconomic perspective. Contradictions of this kind of selective tactical decisions from the point of view of business strategy within the national economy are considered. The problems of such sectoral tactical decisions are analyzed in terms of their direct and indirect impact on the development of socio-economic processes in the country. Potential ways to smooth out the contradictions of tactical and strategic decisions in the interests of domestic business development are demonstrated.
Statistical Analysis of Tuberculosis in Jigawa State, North-Western Nigeria
Authors: Baba Isa Abdullahi , Hincal Evren
Published: April 2020

Studies on Tuberculosis (TB) in Jigawa, a Northwestern state in Nigeria, is very scarce as Tuberculosis and Leprosy Control Center in the state started functioning properly only recently in 2009. Since then, there has been a hike in the number of TB patients visiting the center. This study is conducted to analyze the incidence of Tuberculosis in the state. Data used is obtained from Tuberculosis and Leprosy Control Center, Ministry of Health, Jigawa State, Nigeria. Questioners are used for the collection of the available data for the period of six years (2009–2014). Linear regression is used to analyze the trend of the disease from the same period. Trends within various age groups were recorded. HIV co–infection is analyzed and its trend is also recorded over the years. Gender parity is also analyzed using a t-test. There is an increase in the number of patients from 2009 to 2014. Out of the 9590 patients seen in the period, 6538 (68.18 %) are males and3052 (31.82%) are females. At-test is used to show the significance in the difference between the number of males and females. It is also found that, there is an increase in the number of HIV co-infection over the said years. The study shows the prevalence of TB is highest among the age group of 25 – 34 (30.15%). The commonest type of TB in the population was smear positive pulmonary TB, with 5853 patients (61.03%). TB in Jigawa state was found to be significantly increasing. Out of all the 9590 patients seen at the center, 6538 (68.18 %) are males and3052 (31.82%) are females. HIV co - infection with Tuberculosis occurred in 9.94% of the patients considered. This study shows a high percentage of infection: 30.14% between the age group of 25-34.In general, Pulmonary TB has a higher prevalence of 95.69% compared to Extra Pulmonary TB that has 4.31%.
Antimicrobial Resistance and Sensitivity among Isolates of Esherichia coli from Urine Samples in Denizli, Turkey
Authors: Kirac Selma , Keskin Dilek , Karahasanoğlu F. Banu
Published: April 2020

Objective: The research was carried out with isolate and determines the antimicrobial sensitivity in E. coli from urinary tract infections in special hospital in Denizli and recorded at specimens. Methods: Urine samples (n=21) were collected from patients with signs and symptoms of Urinary tract infections. Bacteria were isolated and identified by conventional biochemical profile. Antibiotic resistance pattern of E. coli against different antibiotic was determined by Kirby-Baur method. Results: The results revealed that sensitivity rate of antimicrobial agents were in the range of meropenem (100%), norfloxacin and ciprofloxacin (86%), cefotaxime (80%), aztreonam (76%). None of the samples showed no resistance to amikacin, ceftazidime, aztreonam, amoxicillin/clavulanic acid, and meropenem. Out of 21 isolates, 3(14%) isolates showed Multiple Antibiotic Resistance ten to thirteen antibiotics. Conclusion: It is concluded that most of the urinary tract infections in human are caused by E.coli exhibited highest resistance to meropenem (100%), followed by norfloxacin and ciprofloxacin  (86%).
HPTLC Chromatographic Polyphenolic Fingerprints of Plant Species from Eastern Europe
Authors: Bubueanu Corina , Pavaloiu Ramona
Published: April 2020

Polyphenols are plant secondary metabolites. They are important active principles from medicinal plants and food supplement that contain medicinal plants. Experimental data indicate that polyphenols exhibit biological functions, as protection against oxidative stress and degenerative diseases. For identification of polyphenolic compounds in plants high-performance thin layer chromatography (HPTLC) is one of the simple and accurate method, which provide important information regarding chemical composition. The chromatographic polyphenolic fingerprint of the four species analysed (Allium sativum - garlic- green leaves, Allium ursinum - wild garlic - green leaves, Malus pumila - apple tree - leaves, Pyrus communis - pear tree - leaves) revealed the present of  flavonoid glycosides and  hydroxycinnamic acids compounds. Because for all the four species for nutritional and therapeutic purpose are used other part of them (garlic and wild garlic- bulbs and apple and pear-fruits) the results obtained can be a first step for superior valorification of hole plant.
Regenerative Effects of Wharton’s Jelly Stem Cells-Conditioned Medium in UVA-Irradiated Human Dermal Fibroblasts
Authors: Wirohadidjojo Yohanes Widodo , Budiyanto Arief , Soebono Hardyanto
Published: April 2020

Background: Ultraviolet A radiation (UVA) can photo-age skin by suppressing the proliferation, migration, and collagen deposition of human dermal fibroblasts (HDFs). This process occurs because UVA light can inhibit the gene expression of the TGF-β receptor in HDFs. Moreover, Wharton’s Jelly Stem Cells-Conditioned Medium (WJSC-CM) is hypothesized to release microvesicles that contain short m-RNA with regenerative properties.

Objectives: This study aimed to determine the regenerative properties of WJSC-CM on UVA-Irradiated Human Dermal Fibroblasts (UVA-HDFs)

Methods: Passaged fourth of  HDFs obtained from the foreskin of six (11- to 13-year-old) boys were repeatedly irradiated with a total of 10 J/cm2 UVA and treated with various concentrations of WJSC-CM. We used non-irradiated HDFs as positive control. After that, the consumption of TGF-β, cellular proliferation, cellular migration, and collagen deposition of each group were measured and compared.

Results: Compared to the non-irradiated groups, the proliferation rates, migration rates, and collagen deposition of UVA-HDFs significantly decreased (p<0.05). WJSC-CM can improve the consumption of TGF-β, proliferation, and cellular migration of UVA-HDFs. However, WJSC-CM failed to improve the collagen deposition of UVA-HDFs (p>0.05).

Conclusions: WJSC-CM has regenerative properties and is a candidate material for the treatment of prematurely ageing skin induced by UVA-irradiation.

 

Ethical permission: This experiment was permitted by the local ethical permission committee Ref:KE/FK/382/EC with permission letter dated 17-04-2013.
Investigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications
Authors: Hou Yanhao , Wang Weiguang , Bártolo Paulo
Published: April 2020

Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approaches in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(ε-caprolactone) scaffolds reinforced with graphene (G) and graphene oxide (GO) at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, GO seems to show some cytotoxicity, particular at high contents.
Population distribution patterns of Nepenthes reinwardtiana Miq. in Kerangas Forest of Teluk Adang Nature Reserve, Paser Regency
Authors: Wulandari Ratna Juliarti , Sumaryono Muhammad , Suhardiman Ali
Published: April 2020

Teluk Adang Nature Reserve (NR) is one of the Nepenthes habitats in East Kalimantan. One of the four Nepenthes species that can be found in this nature reserve is Nepenthes reinwardtiana or by local people known as anjat datu. The objectives of this study are to determine the population of N. reinwardtiana in Teluk Adang NR by calculating its density and frequency, and  to know its distribution pattern using Morisita index and spatial analysis approach in the form of Nearest Neighbor Analysis and Multi-Distance Spatial Cluster Analysis (Ripley's K Function). To know its distribution pattern, a census method by creating 5m x 5m plot along the observation track was done. The results showed that there were 2,943 individuals of N. reinwardtiana in Teluk Adang NR. Standardized Morisita Dispersion Index was 0.51, 0.55, and 0.51 in Tajur Village, Pasir Mayang Village, and Janju Village, respectively. The spatial distribution of N. reinwardtiana was clustered. Research on the distribution of N. reinwardtiana and its habitat needs to be carried out continuously so that its population in the Teluk Adang NR can be monitored.