bluuebunny/crossref_metadata_2025 huggingface dataset:
The Evolution of Pediatric Spine Surgery: A Bibliometric Analysis of Publications From 1902 to 2023
Authors: Mir Jamshaid M. , Kurland David B. , Cheung Alexander T. M. , Liu Albert , Shlobin Nathan A. , Alber Daniel , Rai Sumedha , Jain Vasvi , Rodriguez-Olaverri Juan C. , Anderson Richard C. E. , Lau Darryl , Kondziolka Douglas , Oermann Eric K.
Published: November 2024

BACKGROUND AND OBJECTIVES:

Pediatric spine surgery has evolved considerably over the past century. No previous study conducted a bibliometric analysis of the corpus of pediatric spine surgery. We used big data and advanced bibliometric analyses to evaluate trends in the progression of pediatric spine surgery as a distinct field since the beginning of the 20th century.

METHODS:

A Web of Science query was designed to capture the representative corpus of pediatric spine literature. Statistical and bibliometric analyses were performed using various Python packages and the Bibliometrix R package.

RESULTS:

The collection, published from 1902 to 2023, comprised a total of 11 861 articles from 61 journals and 32 715 unique authors. The overall growth rate annually for publications was 5.08%. An upsurge in publications was seen in the 1980s, after the advent of specialty and subspecialty journals. Illustratively, over 90% of all articles pertaining to pediatric spine surgery were published in the past 3 decades. International and domestic collaboration also increased exponentially over this time period. Reference publication year spectroscopy allowed us to identify 75 articles that comprise the historical roots of modern pediatric spine surgery. There was a recent lexical evolution of topics and terms toward alignment, outcomes, and patient-centric terms. Coauthorship among under-represented groups increased since 1990, but remains low, with disparities persisting across journals.

CONCLUSION:

This comprehensive bibliometric analysis on the corpus of pediatric spine surgery offers insight into the evolving landscape of research, authorship, and publication trends over the past century. Advancements in the understanding of the natural history and technology have led the field to become increasingly outcomes focused, all of which have been fueled by pioneering authors. While diversity among authors improves, under-representation of various groups continues to persist, indicating a critical role for further outreach and promotion.
Novel Delivery of Cryoablation Through Transoral Surgical Approach for Atypical Presentation of Osteoid Osteoma of the C1 Lateral Mass: Technical Case Illustration
Authors: Dharia Anand A. , Bhargav Adip G. , Kaufman Christian B. , Rivard Douglas C. , Grabb Paul A.
Published: November 2024

BACKGROUND AND IMPORTANCE:

Neurosurgical literature rarely explores cases of osteoid osteomas of the atlas. Traditionally, neurosurgeons performed en bloc surgical resection for refractory osteoid osteomas in the subaxial and lumbar spine, but minimally invasive ablation therapies have gained favor. Complete lesioning of the nidus, either by surgical or minimally invasive therapies, produces curative results with recurrence only developing after partial lesioning.

CLINICAL PRESENTATION:

We discuss the case of a 16-year-old adolescent boy who presented with neck and occipital pain refractory to multimodal pain management. Prolonged workup demonstrated a subtle radiographic lesion of the left C1 lateral mass. Interventional radiologists attempted a posterior approach percutaneous computed tomography-guided radiofrequency ablation but aborted due to proximity of the vertebral artery. Surgeons then pursued an open transoral approach to provide a corridor for cyclical cryoablation therapy, which proceeded without complication. The patient was discharged on postoperative day one with remission of occipital pain at the 10-month follow-up. No clinical or radiographic evidence of instability appeared on postoperative cervical films.

CONCLUSION:

No reports exist in the literature of an osteoid osteoma of C1 treated by an open anterior approach and with cryoablation. The transoral approach is a safe, effective method to access ventral pathologies of C1. The transoral approach may minimize blood loss and reduce the risk of craniocervical instability, allowing for preserved cervical mobility and improved patient outcomes. Surgeons may especially consider cryoablation when the nidus is within proximity to critical neural structures.
Does an Unintended Durotomy in Metastatic Spine Surgery Lead to Shorter Survival?
Authors: Gangavarapu Lakshmi Suryateja , Chanbour Hani , Bendfeldt Gabriel A. , Younus Iyan , Jonzzon Soren , Chotai Silky , Abtahi Amir M. , Stephens Byron F. , Zuckerman Scott L.
Published: November 2024

BACKGROUND AND OBJECTIVES:

Whether unintended durotomy in metastatic spine surgery seeds tumor in the central nervous system (CNS) remains unknown. Our objectives were to (1) determine the rate of unintended durotomy, (2) identify the preoperative and perioperative factors that increase the risk of unintended durotomy, and (3) determine whether unintended durotomy affected local recurrence (LR), any spinal recurrence, and overall survival.

METHODS:

A single-center, retrospective cohort study of patients undergoing metastatic spine surgery between January 2010 to January 2021 was undertaken. The primary exposure variable was the occurrence of unintended durotomy. Multivariable logistic/linear regression were performed controlling for age, body mass index, tumor size, other organ metastases, and preoperative radiotherapy/chemotherapy.

RESULTS:

Of 354 patients undergoing surgery for extradural spinal metastasis, 19 patients (5.4%) had an unintended durotomy. Preoperatively: No difference was found between patients with and without unintended durotomy regarding basic demographics, comorbidities (P = .645), or tumor histology (P = .642). Preoperative chemotherapy/radiotherapy were similar between the 2 groups. Perioperatively: Although patients with unintended durotomy had more costotransversectomies (36.8% vs 12.8%, P = .010), no difference was found in tumor characteristics, operative time (337.4 vs 310.6 minutes, P = .150), blood loss (1012.8 vs 883.8 mL, P = .157), length of stay (6.4 vs 6.9 days, P = .452), or overall reoperation/readmission. Long-term: No difference was seen in CNS spread between those with unintended durotomy and no durotomy (10.5% vs 3.0%, P = .077). LR (5.3% vs 12.2%, P = .712), time to LR (388.0 vs 213.3 ± 359.8 days, log-rank; P = .709), any spinal recurrence (26.3% vs 34.0%, P = .489), overall survival (21.05% vs 34.3%, P = .233), and time to death (466.9 ± 634.7 vs 465.8 ± 665.4 days, log-rank; P = .394) were similar on multivariable Cox regressions.

CONCLUSION:

In patients undergoing surgery for extradural spinal metastases, 5% had an unintended durotomy, and costotransversectomies were associated with increased risk of an unintended durotomy. Unintended durotomies did not lead to increased LR or shorter survival. Taken together, shortened survival due to seeding tumor into the CNS after an unintended durotomy was not observed.
The Second-Set Surgeries for Multiple Unruptured Aneurysms Do Not Increase Perioperative Complications
Authors: Nounaka Yohei , Shirokane Kazutaka , Matano Fumihiro , Koketsu Kenta , Kubota Asami , Morita Akio , Murai Yasuo
Published: November 2024

BACKGROUND AND OBJECTIVES:

Intracranial aneurysms affect 3% to 4% of the population, with 20% to 25% having multiple aneurysms. Aggressive treatment is warranted for multiple unruptured aneurysms because of their higher risk of rupture and enlargement compared with single aneurysms. However, the risks and appropriate timing of secondary clipping surgeries are underreported. We assessed the prognosis and risks of treating multiple cerebral aneurysms with a second surgery and determined the differences in prognosis based on the timing of these surgeries.

METHODS:

We retrospectively reviewed patients who underwent secondary clipping surgery for multiple unruptured cerebral aneurysms at our hospital and affiliated institutions. The number, size, and location of aneurysms, patient demographics, and antithrombotic drug history were compared between the first and second surgeries. The modified Rankin Scale score and postoperative complications, including ischemia, hemorrhage, seizures, chronic subdural hematoma requiring surgery, infection, and postoperative hospital days, were investigated.

RESULTS:

A total of 38 patients (mean age, 65 years) were included. No significant differences were observed in modified Rankin Scale score worsening, postoperative hospital stay, or complication rates between the 2 surgeries. Older patients tended to undergo the second surgery within 6 months, with no significant difference in complication rates. The first surgery targeted larger aneurysms.

CONCLUSION:

The absence of complications between surgeries and the absence of rupture or re-treatment during follow-up emphasize the importance of choosing the most appropriate approach for each aneurysm. The first and second surgeries for multiple cerebral aneurysms did not significantly affect postoperative complications. Performing 2 craniotomies may facilitate the curative and safe treatment of aneurysms.
Complete Surgical Resection of a C3 Neuroenteric Cyst With Concurrent Cervical Fusion Deformity Through Posterior Midline Approach in the Lateral Position: Case Report
Authors: Huang Jin , Chen Yuning , Chen Kefei , Ji Wei , Shao Junfei , Guan Jian
Published: November 2024

BACKGROUND AND IMPORTANCE:

Enterogenic cysts often occur along the spinal axis and are frequently associated with congenital spinal malformations. The special location of the lesion can limit the surgical resection to achieve complete removal. In this report, the authors describe a successful case of complete resection of a ventral enterogenic cyst in the cervical spinal cord using a posterior midline approach in the lateral position.

CLINICAL PRESENTATION:

This report discusses a case of a 36-year-old young female patient who presented with relatively short-term discomfort and pain in the left shoulder and neck area. MRI examination revealed a cystic mass located ventrally in the C3 cervical spinal cord. We performed a posterior surgical approach and, under the lateral position, the lesion was completely resected. The surgical treatment alleviated the neurological dysfunction. During the follow-up periods of 3 and 6 months, the patient recovered well, and magnetic resonance imaging scans showed no residual lesion.

CONCLUSION:

Complete surgical resection of the cyst wall is the only effective treatment for enterogenic cysts because partial resection or subtotal resection may lead to recurrence. For patients with concomitant spinal malformations, a posterior midline approach in the lateral position is a viable surgical option.
Methodology for the Formulation of the Guidelines for the Management of Moderate to Severe Traumatic Brain Injury in Austere and Combat Environments
Authors: Puffer Ross C. , Rubiano Andres M. , Oczkowski Simon , Hawryluk Gregory W. J. , Ghajar Jamshid , Mangat Halinder S. , Bell Randy , Rosenfeld Jeffrey V. , Lucena Lynne Lourdes N. , Copeland William R , Mallory Grant , Cota Scott , Dengler Bradley A.
Published: November 2024

Care for the patient with traumatic brain injury (TBI) in austere or combat environments is challenging because resources are substantially limited as compared with care for these patients in a tertiary medical facility. Significant research has been and will continue to be performed on TBI care in these settings. This includes high-quality, evidence-based guidelines that are routinely updated to help guide the treating team as to best practices for a wide range of TBI presentations, complications, and outcomes. Much less is known regarding best practices for TBI care in a resource-limited environment, such as a facility in an austere environment without advanced imaging, dedicated neurointensive care, or definitive neurosurgical capabilities. The aim of this study was to identify the methodology that will be used for an upcoming in-person guideline conference, focusing on the care of patients with TBI in resource-limited austere and/or combat zones.
Bone Regrowth After Frontal Burr Hole Craniostomy: Natural History of 14-mm and 20-mm Burr Holes and Implications for Postoperative Trans-Burr Hole Ultrasound
Authors: Antar Albert , Lee Ryan P. , Sattari Shahab Aldin , Meggyesy Michael , Ahn Jheesoo , Weber-Levine Carly , Jiang Kelly , Huang Judy , Luciano Mark
Published: November 2024

BACKGROUND AND OBJECTIVE:

Burr hole craniostomy is performed for ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy in patients with cerebrospinal fluid disorders. These burr holes are increasingly being used as windows for postoperative ultrasound, an investigational alternative to computed tomography or MRI for follow-up imaging of ventricular caliber. However, bone regrowth reduces ultrasound visibility, and little is known about burr hole regrowth rates in adults. Our study evaluates burr hole regrowth patterns and implications for transcranial ultrasound imaging.

METHODS:

We retrospectively analyzed 101 consecutive patients who had frontal burr hole craniostomy for new ventriculoperitoneal shunt insertion or endoscopic third ventriculostomy over a 3-year period. A mix of standard 14-mm burr holes and expanded 20-mm burr holes were used. Burr hole bone regrowth was assessed using serial follow-up computed tomography scans. Linear and logistic regression analyses examined if bone regrowth correlated with any clinical variables.

RESULTS:

There was wide variability in rate and degree of burr hole regrowth. The average percentage closure was 25% at 6 months, with minimal additional closure over the following 18 months. The mean residual diameter for 14-mm and 20-mm burr holes stabilized around 9.4 mm and 15.4 mm, respectively. Bone regrowth was not associated with patient characteristics, including age, sex, skull thickness, or etiology of cerebrospinal fluid disorder. Rate of bone regrowth was similar between both cohorts.

CONCLUSION:

Bone regrowth after burr hole craniostomy is common, even in elderly patients, occurring rapidly within the first 6 to 12 months and subsequently stabilizing. It is frequently severe enough to restrict ultrasound visualization. Regrowth could not be predicted with any investigated variables, so uniform techniques are needed to block regrowth to allow for longitudinal ultrasound imaging, such as full-thickness cylindrical burr hole implants.
Proximity labeling reveals interactions necessary to maintain the distinct apical domains of Drosophila photoreceptors
Authors: Sastry Lalitha , Rylee Johnathan , Mahato Simpla , Zelhof Andrew C.
Published: November 2024

Specialized membrane and cortical protein regions are common features of cells and are utilized to isolate differential cellular functions. In Drosophila photoreceptors, the apical membrane domain is defined by two distinct morphological membranes: the rhabdomere microvilli and the stalk membrane. To define the apical cortical protein complexes, we performed proximity labeling screens utilizing the rhabdomeric-specific protein PIP82 as bait. We found that the PIP82 interactome is enriched in actin-binding and cytoskeleton proteins, as well as proteins for cellular trafficking. Analysis of one target, Bifocal, with PIP82 revealed two independent pathways for localization to the rhabdomeric membrane and an additional mechanism of crosstalk between the protein complexes of the rhabdomeric and stalk membranes. The loss of Bifocal, and enhancement in the PIP82, bifocal double mutant, resulted in the additional distribution of Crumbs, an apical stalk membrane protein, to the lateral basal photoreceptor membrane. This phenotype was recapitulated by the knockdown of the catalytic subunit of Protein phosphatase 1, a known interactor with Bifocal. Taken together, these results expand our understanding of the molecular mechanisms underlying the generation of the two distinct photoreceptor apical domains.
Choroidal thickness measurement in central serous chorioretinopathy using swept source optical coherence tomography: an observational study
Authors: K. Al-Rubiay Yasser , K. Mohammad Najah
Published: November 2024

Background Central serous chorioretinopathy (CSCR) is a common retinal condition with an increased risk of recurrence. Traditional approaches have made choroidal visualization challenging, but recent advances in optical coherence tomography (OCT) innovation have permitted the collection of more accurate choroidal visualizations. This study aimed to measure choroidal thickness in eyes with active CSCR as well as in the unaffected opposite eyes of these same individuals. Methods This research was conducted at the ophthalmology division in Ghazi Al-Hariri Hospital from the 1st of October 2019 until the 31st of March 2020. A total of 49 people, corresponding to 65 eyes, were included in the study. Among these participants, 16 individuals presented with central serous chorioretinopathy (CSCR), affecting a total of 32 eyes. The CSCR individuals were further split into two groups: “Group A” consisted of 20 eyes with active CSCR, and “Group B” encompassed the remaining 12 unaffected opposite eyes. Additionally, the right eyes of 33 individuals who were age and gender-matched served as controls assigned as “Group C”. Results The choroid exhibited a substantial rise in thickness across each of the nine sectors in group A as compared to group C. Similarly, group B showed a significant increase in choroidal thickness in relation to group C. The mean subfoveal choroidal thickness (SFCT) was measured as follows: 474.55μm, 437.5μm, and 292.03μm among groups A, B, and C, correspondingly. These differences were identified as clinically significant for both A vs. C and B vs. C. Conclusions This study’s findings indicate a thickening of the choroid in both eyes exhibiting active CSCR, as well as in the unaffected opposite eyes of those with the disease.
Health care workers hospitalized for COVID-19 in Liberia: who were they, and what were their outcomes?
Authors: Lehyen Darius B. , Ako-Egbe Louis , Dwalu Emmanuel , Vonhm Benjamin T. , Thekkur Pruthu , Zachariah Rony , Bawo Luke
Published: November 2024

Background Sustaining a ‘fit-for-purpose’ health workforce requires a better understanding of the health care worker cadres that are affected during pandemics and their outcomes. In hospitalized health care workers with confirmed COVID-19 between March 2020 and May 2023 in Liberia, we determined the hospitalization and case fatality rates, type of health care worker cadres affected, their demographic and clinical characteristics and hospital exit outcomes. Methods This was a cohort study using routine data extracted from hospitalization forms for health care workers in 24 designated COVID-19 treatment facilities. Results Of the 424 health care workers with COVID-19, hospitalization rates progressively declined between 2020 and 2023, (P<0.001) with the highest rates in 2020 (24/1,000 health care workers) and 2021 (14/1,000 health care workers). Case fatality was 2% in both 2020 and 2021 with no deaths thereafter. Among those hospitalized, the highest proportions were nursing cadres with 191(45%), physicians with 63 (15%) and laboratory technicians with 42 (10%). The most frequent reported site for COVID-19 infection was the health facility (326, 89%). COVID-19 vaccination coverage in health care workers was 20%. The majority (91%) of hospitalizations were for mild symptomatic infections. Even in referral centres (n-52), 18 (35%) were for mild infections. Of the 424 who were hospitalized, 412 (97%) recovered, 9 (2%) died and 3 (1%) either left against medical advice or absconded. Of the nine deaths, none were vaccinated, seven had moderate-to-severe disease but were not referred to specialized COVID-19 treatment centers. Conclusions The hospitalized health care workers for COVID-19 were predominantly clinical and laboratory personnel who were mostly unvaccinated, and health facilities were hot-spots for contracting infections. The triage and referral system was weak with unnecessary hospitalization of mild infections. This study provides useful insights for outbreak preparedness including priority vaccination and improving health care worker safety in Liberia.
Clust&See3.0 : clustering, module exploration and annotation
Authors: Lopez Fabrice , Spinelli Lionel , Brun Christine
Published: November 2024

Background Cytoscape is an open-source software to visualize and analyze networks. However, large networks, such as protein interaction networks, are still difficult to analyze as a whole. Methods Here, we propose Clust&See3.0, a novel version of a Cytoscape app that has been developed to identify, visualize and manipulate network clusters and modules. It is now enriched with functionalities allowing custom annotations of nodes and computation of their statistical enrichments. Results As the wealth of multi-omics data is growing, such functionalities are highly valuable for a better understanding of biological module composition, as illustrated by the presented use case. Conclusions In summary, the originality of Clust&See3.0 lies in providing users with a complete tool for network clusters analyses: from cluster identification, visualization, node and cluster annotations to annotation statistical analyses.
The quality of life in Thai senior table tennis players
Authors: To-aj Oam , Krajangkantamatr Sornpravate , Saenkla Pennapa , Putthasri Weerasak , Chanbanchong Navaporn , Bumrungpanictarworn Apithai
Published: November 2024

Background Table tennis presented a unique and accessible sport for people of all ages, particularly seniors compared to other sports. Methods This study utilized a quantitative with 136 Table tennis players those who registered for attending in the Thailand Master Table tennis Championships 2024 which hosted in January 2024 at Chiangmai. The questionnaire based on the measurement quality of life, WHOQOL Thai version, and analyzed using Descriptive statistics, Pearson Correlation. Results Pearson correlation coefficients between the scores of the quality of life in four dimensions and the overall score revealed significant correlations (p < 0.01) with all dimensions, including physical health, psychological health, social relationships, and environmental health. Conclusions Playing Table tennis for senior in the tournament level helped to improve the quality of life in all domains.
The Demographic Profile of Colorectal Cancer Patients in Indonesia: Insights from a Single Center Experience and Exploration of Immune Response and Survival Outcomes
Authors: Irawan Cosphiadi , Prasetyawaty Findy
Published: November 2024

Background Understanding the demographics, tumor characteristics, genetic mutations, and immune scores in colorectal cancer (CRC) patients may aid in tailoring treatment and predicting survival. Methods This retrospective cohort study assessed clinical parameters, immune scores, and their relationship with survival in patients with CRC. Results The study included 74 patients, mean age 53.7 years, mostly male (53.3%) and aged 41-70 (77.3%). Common comorbidities included cardiovascular diseases (29.3%) and hypertension (21.3%). Adenocarcinoma (74%) primarily affects the colon (73%). KRAS mutations and Microsatellite instability-High (MSI-H)/deficient mismatch repair (dMMR) were found in 1.3% and 16% of patients, respectively. Stage IV (77.3%) and liver metastases (52.7%) were prevalent. Immune score was influenced by cancer stage (p = 0.04) and metastasis (p=0.05). The immune score was not associated with survival (p = 0.181). Patients with comorbidities had lower one- (p = 0.027) and two-year survival rates (p = 0.037) survival rates. Cardiovascular comorbidities negatively impacted one-year survival (p = 0.047) and two-year survival (p = 0.037). The mean survival time was shorter for males (2.047±0.288 vs. 2.781±0.195 years, p = 0.041), patients with comorbidities (1.772±0.371 vs. 2.702±0.188 years, p = 0.017), and cardiovascular comorbidities (1.558±0.316 vs. 2.685±0.207 years, p = 0.038). Comorbidities (unadjusted hazard ratio [HR] 2.948, p = 0.023) and cardiovascular comorbidities (unadjusted HR 2.695, p = 0.046) were initially associated with survival but lost significance after adjusting for confounding variables. Conclusions This study provides insights into CRC patient demographics and their interplay with the immune score and survival.
Evaluation of the fintech era on the performance of Moroccan banks: analysis through non-performing loans
Authors: Sadok Hicham , El Hadi El Maknouzi Mohamed
Published: November 2024

Background This study aims to contribute to a better understanding of the impact of the financial technologies (fintech) era on the performance in the banking sector, measured through non-performing loans (NPL) and their coverage by provisions for NPL. It is a question of knowing whether banking investment in fintech makes it possible to better evaluate the granting of credits, and therefore makes it possible to reduce overdue credits. Methods To this end, the method used consists of using a regression analysis and a Pearson correlation applied to the financial data of Moroccan banks observed during two distinct periods, namely 2007-2014, considered pre-fintech, and the period 2015-2022, considered as the fintech period. Results With the emergence of the fintech era, the Moroccan banking situation improved slightly compared to the pre-fintech period: bad debts did not increase despite the significant increase in net banking income and the size of banking assets during the fintech era. Conclusions The implementation of fintech has improved customer relationship management, credit risk analysis and loan monitoring services, which ultimately reduces non-performing loans and improves the coverage of non-performing loans by provisions. The main implication of the results allows us to deduce that the implementation of fintech makes it possible to have a positive impact on overdue credits, and they are also likely to serve as a lever for the inclusion of those excluded from banking services.
Assessment of Pelargonium graveolens flower essential oil: Antimicrobial, antioxidant, enzyme inhibition and in vivo topical analgesic and anti-inflammatory efficacy as treatment for atopic dermatitis
Authors: EL-OTMANI NAJLAE , el ouazzani Fadoua , Akoh Rania , Ouazzani Rabab , Zeouk Ikrame , Loukili Abdellatif , Bousta Dalila , Zahidi Ahmed
Published: November 2024

Background Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by pruritus and skin barrier dysfunction. This study aims to evaluate the therapeutic potential of Pelargonium graveolens (Geraniaceae) in managing AD symptoms through its essential oil. Methods The chemical composition of Pelargonium graveolens flower essential oil (PFEO) was analyzed using gas chromatography-mass spectrometry (GC-MS). Its antimicrobial, antioxidant, and anti-inflammatory properties were assessed, along with the inhibitory effects of PFEO on key enzymes involved in skin repair: tyrosinase, elastase, and collagenase. An in vivo evaluation of a gel formulation containing PFEO was also conducted to assess its anti-inflammatory and analgesic efficacy. Results GC-MS analysis identified major compounds in PFEO, including Geraniol (22.83%), beta-citronellol (19.51%), naphthalenemethanol (15.36%), and Geranyl tiglate (9.38%), with minor constituents such as linalool (3.81%) and neryl formate (1.31%). PFEO exhibited bacteriostatic activity against various bacterial and fungal strains, including Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), Bacillus anthracis, Streptococcus pyogenes, Staphylococcus epidermidis, Candida albicans, and Malassezia spp. The essential oil also demonstrated significant antioxidant properties and inhibited key enzymes linked to skin alterations in AD. Conclusions PFEO shows promising therapeutic potential for managing symptoms of atopic dermatitis due to its antimicrobial, antioxidant, and anti-inflammatory properties, as well as its analgesic effects. The findings support further exploration of PFEO as a natural alternative in the treatment of AD.
Co-designing ab initio electronic structure methods on a RISC-V vector architecture
Authors: Grima Torres Rogeli , Vizcaíno Pablo , Mantovani Filippo , Gutiérrez Moreno José Julio
Published: November 2024

Ab initio electronic structure applications are among the most widely used in High-Performance Computing (HPC), and the eigenvalue problem is often their main computational bottleneck. This article presents our initial efforts in porting these codes to a RISC-V prototype platform leveraging a wide Vector Processing Unit (VPU). Our software tester is based on a mini-app extracted from the ELPA eigensolver library. The user-space emulator Vehave and a RISC-V vector architecture implemented on an FPGA were tested. Metrics from both systems and different vectorisation strategies were extracted, ranging from the simplest and most portable one (using autovectorisation and assisting this by fusing loops in the code) to the more complex one (using intrinsics). We observed a progressive reduction in the number of vectorised instructions, executed instructions and computing cycles with the different methodologies, which will lead to a substantial speed-up in the calculations. The obtained outcomes are crucial in advancing the porting of computational materials and molecular science codes to (post)-exascale architectures using RISC-V-based technologies fully developed within the EU. Our evaluation also provides valuable feedback for hardware designers, engineers and compiler developers, making this use case pivotal for co-design efforts.
The genome sequence of an ichneumonid wasp, Gelis areator (Panzer, 1804)
Authors: McCulloch James , Crowley Liam M. , Broad Gavin R. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: November 2024

We present a genome assembly from an individual female Gelis areator (ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence has a total length of 228.10 megabases. Most of the assembly (98.97%) is scaffolded into 12 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 25.02 kilobases in length.
Jadwiga Lechicka – kobieta nowa i nowoczesna. Kulturowy porządek i relacja płci w historiografii polskiej
Authors: Piasek Wojciech
Published: November 2024

Jadwiga Lechicka interests the author as a historian. It is this interest that he prioritises, and it is the starting point of his considerations. He presents the book's heroine as a single person – an individual making life choices, having individual desires and expectations for herself. For this purpose, he uses traces – biographemes that show her as a private subject with a unique individual experience, the heroine of her own life. Biographemes are ethnographic information that identifies a private experience but does not provide insight into it. Therefore, the author simultaneously refers to biographemes and to a new model of femininity created by Lechicka's contemporaries – the "new and modern woman", constructed after World War I by the environment with which Lechicka was associated – homo academica. In parallel with his interest in Lechicka as an individual, the author deals with the cultural order and gender relations in interwar and post-war Polish historiography. It is considered from the perspective of Jadwiga Lechicka's experiences, her attitude towards herself and her activities related to education, professional work and family. Diagnosing Lechicka's case, he contextualises her biographemes into a consistent juxtaposition – thanks to the concept of sensitising order and gender relations – with the biographemes of other women and statistical data regarding them.
Imperatywy jako narzędzia formacji chrześcijan w Apokalipsie św. Jana
Authors: Olszewska Karolina
Published: November 2024

The Apocalypse of St. John is not, contrary to its common pop culture understanding, a catalogue of spectacular catastrophes or merely a characterisation of the antichrist stimulating artists’ imagination. It describes the rooting of the life history of believers in the Risen One and the memory of the eschatic perspective. The Church presented in Revelation, as part of the world, experiences crises, issues and dangers (cf. Rev. 1:9; 2:6, 9, 10, 13, 15, 20, 22; 6,9-11; 7,14; 11,7; 12,11 ; 13.11; 17.6 18.24). For this reason, it needs a formator who, using particular tools, will propose a system of repairing or strengthening Christian communities. Looking at the image of the Church contained in the last book of the Holy Scripture and comparing it with the image of today's Church, affected by various difficult situations, one should ask: where can the community presented in Revelation look for its salvation so that it could later use similar tools in the contemporary Church? It seems that one of such ways is the use by the formator of very specific and radical imperative statements addressed to the community. Therefore, the analysis of biblical texts shows what role imperatives play in the specific situation of the Church, what significance they have, what condition their addressees are in, who can be considered a formator and what will be the effect of complying or not complying with these calls.
Historiografia i mitologia kobiecości. Powieściopisarstwo Teodora Parnickiego
Authors: Szewczyk Joanna
Published: November 2024

Prezentowana książka stanowi próbę odczytania alternatywnych historii kobiet w pięciu najwybitniejszych powieściach Teodora Parnickiego. Zawarte w niej interpretacje zostały przeprowadzone z wykorzystaniem narzędzi wypracowanych na gruncie literaturoznawstwa, teorii historiografii, szczególnie zaś z antropologii i feministycznej krytyki literackiej. Studium m na celu odsłonięcie innego wymiaru powieściopisarstwa Teodora Parnickiego, ukazanie Genderowej wrażliwości autora „Nowej Baśni”, niejednokrotnie antycypującego w swej twórczości przemiany zachodzące w ponowoczesnej teorii historiografii. Przedstawione analizy koncentrują się między innymi wokół zagadnień mitologii kobiecości, genealogii matrylineralnej, cielesności w historii oraz problemy płci, traktowanej jako istotny komponent kreowania narracji historycznej. Książka podejmuje również namysł nad relacją łączącą historię, mit i literaturę w powieściach Teodora Parnickiego oraz proponuje spojrzenie na jego twórczość z innej perspektywy, uwzględniając płeć doświadczenia historycznego, stawiającej w centrum zainteresowania postaci kobiet będących aktywnymi kreatorkami rzeczywistości oraz innych kulturowo i etnicznie, sytuujących się na marginesie Wielkiej Historii.
Seminario, una actividad de aprendizaje para grupos pequeños en semiología
Authors: Enríquez Ojeda Juan Fernando
Published: November 2024

En el presente capítulo se presentan los resultados de una investigación realizada para analizar las características del Seminario de Semiología Respiratoria, una actividad de aprendizaje dirigida a grupos pequeños que se imparte a los estudiantes del quinto semestre del programa de Medicina de la Universidad Cooperativa de Colombia sede Pasto.
Diseñando un currículo experiencial para el internado en pediatría
Authors: Gómez Moreno Juan Pablo , Mesa Acosta Andrea Carolina , Rincón Millán Camilo Enrique
Published: November 2024

El internado es una etapa fundamental en la formación del estudiante de Medicina, ya que cualquier falta de interés para el aprendizaje, el autoaprendizaje y la autorreflexión puede significar dificultades en la integración y transferencia de conocimientos al escenario clínico real, así como en la aproximación diagnóstica y el abordaje terapéutico correcto en su futuro papel como médico.
Reformulación microcurricular: normas de comportamiento en el servicio de quirófanos
Authors: Enríquez Ojeda Juan Fernando , Palacios Ortega Esther Roxana
Published: November 2024

A continuación, se presentan los resultados de una investigación desarrollada para develar la estructura de la propuesta microcurricular alrededor de la enseñanza de las normas de comportamiento dentro del quirófano a partir de los currículos concurrentes, trabajo realizado dentro de la asignatura Clínica Quirúrgica, correspondiente al 8° semestre del programa de Medicina de la Universidad Cooperativa de Colombia, sede Pasto.
Evaluación como proceso, estudio de un caso
Authors: Robles Fonnegra William Alberto
Published: November 2024

En este capítulo se presenta una herramienta articuladora del proceso de evaluación: el portafolio, como síntesis del proceso de aprendizaje y de la completitud de las competencias propuestas.
Evaluación de la calidad de una rotación de internado en quirófano
Authors: Enríquez Ojeda Juan Fernando
Published: November 2024

Para este capítulo, se elaboró un estudio de la calidad de la rotación por quirófanos, la cual hace parte del programa de internado rotatorio de la Fundación Hospital San Pedro, centro asistencial de tercer nivel de complejidad ubicado en la ciudad de Pasto y escenario de prácticas formativas que acoge a estudiantes de los tres programas de Medicina del suroccidente colombiano. Corresponde a un estudio observacional descriptivo y se adoptó una metodología mixta, con un muestreo selectivo, incluyendo dos instrumentos de recolección validados por juicio de expertos: un diario de observación y encuestas para docentes y estudiantes orientadas a develar la calidad de los cuatro componentes del modelo cipp (contexto, insumo, proceso y producto). La investigación permitió describir dichas condiciones y sugerir líneas de mejoramiento a partir de los hallazgos.
Hacer realidad el Proyecto MEIP
Authors: Aguia-Rojas Karen , Avendaño-Calderón Angelica , Bermúdez-Hernández Pablo-Andrés , Cadavid Espinha Sara , Ospina-Maldonado Vladimir-Mauricio , Quiroga-Torres Daniel-Alejandro
Published: November 2024

En este capítulo presentamos los aspectos logísticos relacionados con la construcción e implementación de los niveles del Proyecto MEIP, con el objetivo de dar a conocer las distintas dificultades y soluciones que surgieron a lo largo de su diseño, propuesta e implementación. Asimismo, describimos las soluciones formuladas a partir de un proceso de reflexión en equipo y los desafíos que continuamos enfrentando como comunidad de aprendizaje. Primero, describimos la importancia de definir una estructura organizacional para implementar la instrucción (o el currículo). Luego, explicamos los principales aprendizajes desarrollados durante la estrategia de facilitación de los cursos. Por último, narramos los mecanismos de mejora y retroalimentación incorporados en el proceso de construcción de los MEIP.
Satiation-Based Theory of Frugal Materialism
Authors: Zeithammer Robert
Published: November 2024

Frugal materialism is a tendency of consumer demand to become more elastic in product durability in response to a tightening budget constraint. This paper proposes a value function-based model of frugal materialism and establishes a close theoretical link between frugal materialism and the slope of value satiation as defined in the decision analytic literature; for both their absolute and relative versions, frugal materialism and increasing value satiation are nearly equivalent to each other. Only some shapes of the value function are thus compatible with frugal materialism, and the shape restrictions involve concepts familiar from models of decision making under risk, even though the proposed model of frugal materialism does not involve any risk. Under the additional assumption of relative risk neutrality, the demand for risky assets of a frugally materialistic consumer should exhibit well-known behavioral patterns associated with increasing risk aversion, and there is only a narrow possibility for frugal materialism to coexist with precautionary saving behavior.
Code and Data Repository for Binary Quantum Control Optimization with Uncertain Hamiltonians
Authors: Fei Xinyu , Brady Lucas T. , Larson Jeffrey , Leyffer Sven , Shen Siqian
Published: November 2024

The goal of this software is to implement the gradient-based and rounding algorithms proposed in the paper to solve the binary quantum control optimization problem with uncertain Hamiltonians.
A New Multicommodity Network Flow Model and Branch and Cut for Optimal Quantum Boolean Circuit Synthesis
Authors: Jung Jihye , Choi In-Chan
Published: November 2024

This study introduces a new optimization model and a branch-and-cut approach for synthesizing optimal quantum circuits for reversible Boolean functions, which are pivotal components in quantum algorithms. Although heuristic algorithms have been extensively explored for quantum circuit synthesis, research on exact counterparts remains relatively limited. However, the need to design quantum circuits with guaranteed optimality is increasing, especially for improving computational fidelity on noisy intermediate-scale quantum devices. This study presents mathematical optimization as a viable option for optimal synthesis, with the potential to accommodate practical considerations arising in fast-evolving quantum technologies. We set a demonstrative problem to implement reversible Boolean functions using high-level gates known as multiple control Toffoli gates while minimizing a technology-based proxy called quantum cost—the number of low-level gates used to realize each high-level gate. To address this problem, we propose a discrete optimization model based on a multicommodity network and discuss potential future variations at an abstract level to incorporate technical considerations. A customized branch and cut is then developed upon different aspects of our model, including polyhedron integrality, surrogate constraints, and variable prioritization. Our experiments demonstrate the robustness of the proposed approach in finding cost-optimal circuits for all benchmark instances within a two-hour time frame. Furthermore, we present interesting intuitions from these experiments and compare our computational results with relevant studies, highlighting newly discovered circuits with the lowest quantum costs reported in this paper.

History: Accepted by Giacomo Nannicini, Area Editor for Quantum Computing. This paper has been accepted for the INFORMS Journal on Computing Special Issue on Quantum Computing.

Funding: This research was supported by the Ministry of Science and Information and Communication Technology, South Korea [Grants 2017R1E1A1A0307098814 and 2020R1A4A307986411].

Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2024.0562 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2024.0562 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Code and Data Repository for A Novel Noise-Aware Classical Optimizer for Variational Quantum Algorithms
Authors: Larson Jeffrey , Menickelly Matt , Shi Jiahao
Published: November 2024

This software is sufficient to reproduce the simulated results demonstrated in the paper.
Rodas de Leitura Literária (2019-2022): uma experiência na universidade.
Authors: Lopes Giovana Cerqueira , Oliveira Claudia Fernandes de Amorim de , Braz Luiza Barboza
Published: November 2024

A partir da história do tempo presente, propõe-se uma retrospectiva relacionada ao Projeto Rodas de Leitura Literária na EDU, considerando marcos importantes durante a trajetória, desde a sua criação. O surgimento de uma pandemia ocasionou uma adaptação dos eventos. Destaca-se a relevância do projeto Rodas de Leitura Literária a partir do público convidado, com vistas a apresentar os conhecimentos para além do que se passa nos livros, com relevância no processo. Assim, objetivou-se: 1) compreender o projeto em uma perspectiva histórica; 2) relembrar os encontros realizados e as adaptações necessárias nos contextos vividos; 3) descrever o perfil formativo dos convidados. Reafirmamos o caráter social das rodas e a importância da atuação do projeto dentro e fora dos muros da universidade.
Hemeroteca: um lugar de memória do jornalismo de Picos-PI
Authors: Sousa de Oliveira Thamyres , Machado de Sousa Paloma Aparecida , Santos Vieira Thaila Vitoria , Da Silva Modesto Marcos Vinicius , De Sousa Silva Beatriz
Published: November 2024

A extensão tem em seu cerne a missão de transformar e fazer com que a academia e a comunidade andem lado a lado. Desse modo, neste relato de experiência, buscamos compartilhar como o projeto Hemeroteca: um lugar de memória do jornalismo de Picos-PI tem engendrado um lugar de memória do jornalismo na cidade.  A metodologia utilizada no projeto, conforme Warschauer (2017),  se concentra em três círculos principais: 1) planejamento, formação, acompanhamento e avaliação da organização do acervo de memória; 2) garimpagem de publicações jornalísticas e organização do acervo físico; 3) educação para a preservação da memória por meio da realização de minicursos. O projeto tem estimulado o protagonismo discente e mostrado que a educação se constrói também pela afetividade.
Principles of medicine management: how medicines work
Authors: Peate Ian
Published: November 2024

This article provides an insight and understanding regarding the ways in which medicines work. The article aims to provide healthcare assistants and assistant practitioners with a guide to how the body processes medicines and therapeutic uses of common medications. The criteria used to classify drugs are discussed, including their structure, therapeutic use, mode of action and regulatory status. The common compositions and preparations of medications are outlined along with the various routes of administration. Finally, the importance of understanding the needs of specific groups, mainly older people and children, is highlighted.
A new species of Coeliaria Mulsant, 1850 (Coleoptera: Coccinellidae: Coccinellinae: Chnoodini) from northeastern Brazil
Authors: CELANTE GABRIEL LUIZ , JAHYNY BENOIT JEAN BERNARD , SILVA ARAÚJO KAYLLA BRISLEY , BATISTA DOS SANTOS PAULA
Published: November 2024

The ladybird genus Coeliaria Mulsant, 1850 (Coleoptera: Coccinellidae: Coccinellinae: Chnoodini) includes five species distributed in South America. We describe and illustrate a new species, Coeliaria almeidae sp. nov., found in Casa Nova, Bahia, Brazil. It is the second found in the Northeast Region of Brazil and the first in the Caatinga. We provide an updated identification key for all species of Coeliaria and present new notes on morphology, host plants and prey records. We also provide new records of Coeliaria bernardinensis (Brèthes, 1925).