bluuebunny/crossref_metadata_2025 huggingface dataset:
Lattices over Bass Rings and Graph Agglomerations
Authors: Baeth Nicholas R. , Smertnig Daniel
Published: March 2021

We study direct-sum decompositions of torsion-free, finitely generated modules over a (commutative) Bass ring R through the factorization theory of the corresponding monoid T(R). Results of Levy–Wiegand and Levy–Odenthal together with a study of the local case yield an explicit description of T(R). The monoid is typically neither factorial nor cancellative. Nevertheless, we construct a transfer homomorphism to a monoid of graph agglomerations—a natural class of monoids serving as combinatorial models for the factorization theory of T(R). As a consequence, the monoid T(R) is transfer Krull of finite type and several finiteness results on arithmetical invariants apply. We also establish results on the elasticity of T(R) and characterize when T(R) is half-factorial. (Factoriality, that is, torsion-free Krull–Remak–Schmidt–Azumaya, is characterized by a theorem of Levy–Odenthal.) The monoids of graph agglomerations introduced here are also of independent interest.
Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations
Authors: Lee Jii Bum , Jung Minkyu , Beom Seung Hoon , Kim Gun Min , Kim Hye Ryun , Choi Hye Jin , Sohn Joo Hyuk , Ahn Joong Bae , Rha Sun Young , Chung Hyun Cheol
Published: March 2021

TAS-117 is a potent and selective allosteric pan-v-akt murine thymoma viral oncogene homolog (Akt) inhibitor. We conducted a single-arm single-center phase 2 study of TAS-117 in heavily treated patients with tumors refractory to systemic chemotherapy and harboring phosphatidylinositol 3-kinase (PI3K)/Akt mutations. Patients with gastrointestinal (GI) cancers were orally administered 16 mg TAS-117 daily, and those with non-GI tumors were administered 24 mg on a 4 days on/3 days off schedule. The primary endpoint was overall response rate (ORR). Secondary endpoints included disease control rate (DCR), progression-free survival (PFS), overall survival (OS), PFS ratio, safety, and tolerability. Thirteen patients were enrolled: eight with non-GI (breast, ovarian, endometrial, and non-small cell lung) and five with GI (colon, rectal, gastric, and gallbladder) cancers. Ten patients were treated with TAS-117 after ≥ 4 lines of therapy. Twelve patients showed PIK3 catalytic subunit alpha (PIK3CA) mutations; one harbored an Akt1E17K mutation. The median treatment duration was 1.4 months; the median number of treatment cycles was 2. The ORR was 8 %, and DCR was 23 %. The median PFS and OS were 1.4 and 4.8 months, respectively. Grade 3–4 treatment-related adverse events were anorexia (grade 3, 8 %) and hyperglycemia (grade 3, 8 %; grade 4, 8 %).Grade 3–4 treatment-related adverse events occurred in 27 % of grade 3 anorexia (9 %) and hyperglycemia (grade 3, 8 %; grade 4, 9\%). TAS-117 showed limited antitumor activity and manageable toxicity. Clinical efficacy was observed in patients with ovarian cancer harboring PIK3CA E545K mutations and in patients with breast cancer harboring PIK3CA H1047R and Akt1E17K mutations.

Trial registration: This study was retrospectively registered with ClinicalTrial.gov (NCT03017521 on January 11, 2017).
An Intrinsic Material Tailoring Approach for Functionally Graded Axisymmetric Hollow Bodies Under Plane Elasticity
Authors: Abdalla Hassan Mohamed Abdelalim , Casagrande Daniele
Published: March 2021

One of the main requirements in the design of structures made of functionally graded materials is their best response when used in an actual environment. This optimum behaviour may be achieved by searching for the optimal variation of the mechanical and physical properties along which the material compositionally grades. In the works available in the literature, the solution of such an optimization problem usually is obtained by searching for the values of the so called heterogeneity factors (characterizing the expression of the property variations) such that an objective function is minimized. Results, however, do not necessarily guarantee realistic structures and may give rise to unfeasible volume fractions if mapped into a micromechanical model. This paper is motivated by the confidence that a more intrinsic optimization problem should a priori consist in the search for the constituents’ volume fractions rather than tuning parameters for prefixed classes of property variations. Obtaining a solution for such a class of problem requires tools borrowed from dynamic optimization theory. More precisely, herein the so-called Pontryagin Minimum Principle is used, which leads to unexpected results in terms of the derivative of constituents’ volume fractions, regardless of the involved micromechanical model. In particular, along this line of investigation, the optimization problem for axisymmetric bodies subject to internal pressure and for which plane elasticity holds is formulated and analytically solved. The material is assumed to be functionally graded in the radial direction and the goal is to find the gradation that minimizes the maximum equivalent stress. A numerical example on internally pressurized functionally graded cylinders is also performed. The corresponding solution is found to perform better than volume fraction profiles commonly employed in the literature.
The efficacy of catheter ablation versus ICD for prevention of ventricular tachycardia in patients with ischemic heart disease: a systematic review and meta-analysis
Authors: Liu Guolin , Xu Xin , Yi Qijian , Lv Tiewei
Published: March 2021

Purpose

Although implantable cardioverter defibrillator (ICD) could prevent the sudden death of ventricular tachycardia (VT) in patients with ischemic heart disease, it could not effectively prevent the recurrence of ventricular tachycardia. Several studies have suggested that catheter ablation may effectively decrease the incidence of ICD events, but relevant dates from randomized controlled trials were limited.

Methods

A systematic review and meta-analysis of randomized controlled trials were performed to evaluate the effect of catheter ablation for the prevention of VT in patients with ischemic heart disease. Random-effects model with inverse-variance weighting method was used to pool odds ratios. Egger method was performed to evaluate whether there was public bias in each outcome.

Results

Four studies enrolling a total of 605 patients were included in the present meta-analysis. Compared with the control group (ICD ± AAD), catheter ablation could significantly reduce the incidence of ICD therapy (OR, 0.49; 95% CI, 0.28 ~ 0.87), ICD shock (OR, 0.50; 95% CI, 0.28 ~ 0.87), VT storm (OR, 0.60; 95% CI, 0.40 ~ 0.90), and cardiovascular-related hospitalization (OR, 0.66; 95% CI, 0.45 ~ 0.9). But there was no significant difference among the risk of all-cause mortality (OR, 0.89; 95% CI, 0.59 ~ 1.34), cardiovascular mortality (OR, 0.76; 95% CI, 0.44 ~ 1.30), and complication (OR, 0.89; 95% CI, 0.30 ~ 2.67).

Conclusion

These results showed that catheter ablation combined with ICD could reduce ICD therapy, ICD shock, and VT storm in patients with ischemic heart disease, but there was no improvement in all-cause mortality. Meanwhile, it also provided a basic guidance for the design of larger clinical randomized trials with longer follow-up in the future.
Long-term trends of oxygen concentration in the waters in bank and shelves of the Southern Japan Sea
Authors: Ono Tsuneo
Published: March 2021

While multiple studies have investigated oxygen decrease in Japan Sea Proper Water (JSPW; > 300 m in depth), oxygen variation in continental slope and shelf waters (< 300 m) must also be investigated in order to assess its socioecological impacts. In this study, historical oxygen data in the waters of three continental shelves and a bank of Japan Sea, off-Awashima area (AW), Wakasa Bay (WB), East of Tsushima Straight (ETS), and Yamato Bank (YB), were collected and analyzed to assess temporal variation of oxygen in each region from 1960 to 2000s. Significant decreasing trends of oxygen were detected in the waters below 150 m depth in WB and YB, and below 300 m in AW, in the summer season. In winter, a decreasing trend of oxygen was detected throughout the water column from 300 m to the sea surface in WB and YB. In ETS, a deoxygenation trend was detected throughout the water column from the bottom to the sea surface in the summer season, while no trend was detected in winter. The results suggested that oxygen decreases in AW, WB, and YB were the consequence of the upward propagation of the deoxygenation signal from JSPW, while that of ETS was caused by horizontal propagation of deoxygenation signal from the East China Sea. Assuming that the observed trend will continue in future, it is predicted that part of the water in Tsushima Strait area will reach the general sublethal threshold of oxygen (134 μmol kg−1) by the end of this century.
From hostile worlds to multiple spheres: towards a normative pragmatics of justice for the Googlization of health
Authors: Sharon Tamar
Published: March 2021

The datafication and digitalization of health and medicine has engendered a proliferation of new collaborations between public health institutions and data corporations like Google, Apple, Microsoft and Amazon. Critical perspectives on these new partnerships tend to frame them as an instance of market transgressions by tech giants into the sphere of health and medicine, in line with a “hostile worlds” doctrine that upholds that the borders between market and non-market spheres should be carefully policed. This article seeks to outline the limitations of this common framing for critically understanding the phenomenon of the Googlization of health. In particular, the mobilization of a diversity of non-market value statements in the justification work carried out by actors involved in the Googlization of health indicates the co-presence of additional worlds or spheres in this context, which are not captured by the market vs. non-market dichotomy. It then advances an alternative framework, based on a multiple-sphere ontology that draws on Boltanski and Thevenot’s orders of worth and Michael Walzer’s theory of justice, which I call a normative pragmatics of justice. This framework addresses both the normative deficit in Boltanski and Thevenot’s work and provides an important emphasis on the empirical workings of justice. Finally, I discuss why this framework is better equipped to identify and to address the many risks raised by the Googlization of health and possibly other dimensions of the digitalization and datafication of society.
Psychometric properties of the Polish version of the 36-item WHODAS 2.0 in patients with hip and knee osteoarthritis
Authors: Bejer Agnieszka , Ćwirlej-Sozańska Agnieszka , Wiśniowska-Szurlej Agnieszka , Wilmowska-Pietruszyńska Anna , Spalek Renata , de Sire Alessandro , Sozański Bernard
Published: March 2021

Purpose

To examine psychometric properties of the Polish version of the 36-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) in the population with hip and knee osteoarthritis (OA).

Methods

This was a longitudinal study with repeated measures during retest examinations. Subjects from a Polish Specialist Hospital (age = 68.3 ± 9.2years, 71% female, 44.2% knee OA, 55.8% hip OA) were tested three times. They completed the Polish version of the 36-item WHODAS 2.0, the SF-36 Health Survey 2.0, the Western Ontario and Macmaster Universities Osteoarthritis Index 3.1, the Hospital Anxiety and Depression Scale, and the Numerical Rating Scale.

Results

The 36-item WHODAS 2.0—Polish version demonstrated high internal consistency (Cronbach’s alpha for total = 0.94), and test–retest reliability (Total ICC2,1 = 0.98). High construct validity was found as 12 out of 15 a priori hypotheses (80%) were confirmed. Most domains and Total Scores in the 36-item WHODAS 2.0 (Total ES = − 0.62, SMR = − 1.09) showed a moderate degree of responsiveness. Minimal clinically important difference (MCID) for the Total WHODAS 2.0 was 3.29 in patients undergoing rehabilitation for knee or hip OA.

Conclusions

The Polish version of the 36-item WHODAS 2.0 assesses disability according to ICF in a reliable, valid and responsive way. Therefore, it provides considerable support in clinical practice and national and international scientific research of patients with hip or knee OA.
Intentions to quit upper secondary education among first generation immigrants and native Norwegians: the role of loneliness and peer victimization
Authors: Fandrem Hildegunn , Tvedt Maren Stabel , Virtanen Tuomo , Bru Edvin
Published: March 2021

Dropout from upper secondary education is a persistent educational problem, particularly among first-generation immigrant youth. This study examined factors associated with intentions to dropout to gain further insight into the process of leaving upper secondary education. The analyses of 1299 Norwegian first-year upper secondary school students’ (88% native Norwegians, 12% first-generation immigrants) self-reported intentions to quit school, loneliness, and peer victimization in school showed that first-generation immigrants experienced higher levels of loneliness than native Norwegians. In contrast, there were no differences in the levels of peer victimization and intentions to quit between native Norwegians and first-generation immigrants. However, loneliness showed a significantly stronger association with intentions to quit among first-generation immigrants. The results underscore the importance of tackling first-generation immigrants’ loneliness in school to reduce their intentions to quit upper secondary education and thus potentially improve conditions for school completion.
How to have a metalinguistic dispute
Authors: Mankowitz Poppy
Published: March 2021

There has been recent interest in the idea that speakers who appear to be having a verbal dispute may in fact be engaged in ametalinguistic negotiation: they are communicating information about how they believe an expression should be used. For example, individuals involved in a dispute about whether a racehorse is an athlete might be communicating their diverging views about how ‘athlete’ should be used. While many have argued that metalinguistic negotiation is a pervasive feature of philosophical and everyday discourse, the literature currently lacks an account of this phenomenon that can be situated within a ‘mainstream’ view of communication. I propose an independently motivated account where individuals reconstruct metalinguistic propositions by means of a pragmatic, Gricean reasoning process.
Taking values seriously
Authors: Bykvist Krister
Published: March 2021

Recently, there has been a revival in taking empirical magnitudes seriously. Weights, heights, velocities and the like have been accepted as abstract entities in their own right rather than just equivalence classes of objects. The aim of my paper is to show that this revival should includevaluemagnitudes. If we posit such magnitudes, important value comparisons (cross-world, cross-time, mind to world, cross-theory, cross-polarity, ratio) can be easily explained; it becomes easier to satisfy the axioms for measurement of value; goodness, badness, and neutrality can be given univocal definitions; value aggregation can be given a non-mathematical understanding which allows for Moorean organic unities. Of course, this does not come for free. One has to accept a rich ontology of abstract value magnitudes, but, to quote David Lewis, ‘The price is right; the benefits in theoretical unity and economy are well worth the entities.’
Perturbation Solution for One-Dimensional Flow to a Constant-Pressure Boundary in a Stress-Sensitive Reservoir
Authors: Bhullar Amarjot Singh , Stewart Gospel Ezekiel , Zimmerman Robert W.
Published: March 2021

Most analyses of fluid flow in porous media are conducted under the assumption that the permeability is constant. In some “stress-sensitive” rock formations, however, the variation of permeability with pore fluid pressure is sufficiently large that it needs to be accounted for in the analysis. Accounting for the variation of permeability with pore pressure renders the pressure diffusion equation nonlinear and not amenable to exact analytical solutions. In this paper, the regular perturbation approach is used to develop an approximate solution to the problem of flow to a linear constant-pressure boundary, in a formation whose permeability varies exponentially with pore pressure. The perturbation parameter αD is defined to be the natural logarithm of the ratio of the initial permeability to the permeability at the outflow boundary. The zeroth-order and first-order perturbation solutions are computed, from which the flux at the outflow boundary is found. An effective permeability is then determined such that, when inserted into the analytical solution for the mathematically linear problem, it yields a flux that is exact to at least first order in αD. When compared to numerical solutions of the problem, the result has 5% accuracy out to values of αD of about 2—a much larger range of accuracy than is usually achieved in similar problems. Finally, an explanation is given of why the change of variables proposed by Kikani and Pedrosa, which leads to highly accurate zeroth-order perturbation solutions in radial flow problems, does not yield an accurate result for one-dimensional flow.

Article Highlights

Approximate solution for flow to a constant-pressure boundary in a porous medium whose permeability varies exponentially with pressure.

The predicted flowrate is accurate to within 5% for a wide range of permeability
variations.

If permeability at boundary is 30% less than initial permeability, flowrate will be 10% less than predicted by constant-permeability model.
Emotion, Epistemic Assessability, and Double Intentionality
Authors: Magalotti Tricia , Kriegel Uriah
Published: March 2021

Emotions seem to be epistemically assessable: fear of an onrushing truck is epistemically justified whereas,mutatis mutandis, fear of a peanut rolling on the floor is not. But there is a difficulty in understanding whyemotions are epistemically assessable. It is clear why beliefs, for instance, are epistemically assessable: epistemic assessability is, arguably, assessability with respect to likely truth, and belief is by its nature concerned with truth; truth is, we might say, belief’s “formal object.” Emotions, however, have formal objects different from truth: the formal object of fear is danger, the formal object of indignation is injustice, and so on. Why, then, are emotions epistemically assessable too? Here we make a negative claim and a positive claim. On the negative side, we consider how cognitivist and perceptualist accounts of emotion may respond to this challenge, and argue against those responses. On the positive side, we develop an alternative picture of the domain of the epistemically evaluable, according to which any mental state which is constitutively evidence-responsive is epistemically assessable, regardless of whether its formal object is truth.
Scleractinian corals incorporate microplastic particles: identification from a laboratory study
Authors: Hierl Florian , Wu Henry C. , Westphal Hildegard
Published: March 2021

Microplastics have been detected on beaches and in the ocean from surface habitats to the deep-sea. Microplastics can be mistaken for food items by marine organisms, posing a potential risk for bioaccumulation and biomagnification in the food chain. Our understanding of microplastic pollution effects on ecosystem and physiological processes of coral reefs is still limited. This study contributes to the understanding of effects of microplastic pollution on skeletal precipitation of hermatypic corals. In a five month aquarium-based experiment, specimens of four tropical species were temporarily exposed to high concentrations (ca. 0.5 g L-1) of polyethylene terephthalate (PET) microplastic particles (< 500 μm). The coral specimens all survived this treatment and show skeletal growth. The skeletal material produced during the experiment, however, incorporated plastic particles and plastic fibres in the aragonitic structure. Long-term consequences of such inclusions on skeletal properties such as stability are yet unknown.
Efficacy and safety of ferric citrate hydrate compared with sodium ferrous citrate in Japanese patients with iron deficiency anemia: a randomized, double-blind, phase 3 non-inferiority study
Authors: Komatsu Norio , Arita Kojo , Mitsui Hironori , Nemoto Takanori , Hanaki Koji
Published: March 2021

Oral iron preparations are used as first-line treatment for iron deficiency anemia (IDA), but their gastrointestinal side effects prevent patients from appropriate adherence. We recently conducted a randomized, double-blind, phase 3 non-inferiority study to evaluate the efficacy and safety of two dosages of ferric citrate hydrate (FC) compared with sodium ferrous citrate (SF) in patients with IDA. FC at both 500 and 1000 mg/day was non-inferior to SF at 100 mg/day in terms of the change in the hemoglobin concentration at Week 7 from baseline. Logistic regression analysis suggested that the cumulative proportion of patients who achieved the target hemoglobin concentration (≥ 13.0 g/dL in male patients and ≥ 12.0 g/dL in female patients) at Week 7 was highest among those treated with FC at 1000 mg/day, followed by SF at 100 mg/day and FC at 500 mg/day. Both dosages of FC were well tolerated in patients with IDA. The incidences of nausea and vomiting were significantly lower in the FC treatment groups than in the SF group. In conclusion, FC has potential to be an oral iron preparation with sufficient efficacy for the treatment of IDA and a lower risk of nausea and vomiting.
Groundwater fluoride contamination in Coimbatore district: a geochemical characterization, multivariate analysis, and human health risk perspective
Authors: Kumar P. J. Sajil
Published: March 2021

In this paper, fluoride geochemistry and health risk of groundwater in Coimbatore district is studied. The order of dominance of ions were HCO3 > Cl > SO4 > CO3 and Na > Ca > Mg > K. Alkaline groundwater and the dominance of HCO3 and Na is favourable for the fluoride enrichment. Around 46% of the samples, N–NE regions, have F− higher than permissible limit of 1.5 mg/L. Pink granites, charnockite and gneisses in lithology is the possible origin of F−. However, NO3 vs F plot shows positive trend in some samples, indicating anthropogenic inputs of F−. Correlation plots of F− was trending positive with pH, HCO3 and Na and but negative for Ca, indicating the control of these ions in F− mobility. This result is supported by undersaturation of fluorite and supersaturation of carbonates. Four significant principal components were derived, which have explained 87% of the total variation. PC1 has high factor loadings for EC, Ca, Mg Na, Cl, SO4, NO3 indicating both natural and anthropogenic influences. PC2, PC3 and PC4 have higher loading for pH and HCO3, K and HCO3 and F−, respectively, indicating geogenic factors in the F− enrichment. Human health risk assessment (HHRA) by ingestion and dermal pathways were calculated using Hazard Quotient HQ and Hazard Index (HI). 27% of males, 36% of females and 39% of the children have HI > 1, posing noncarcinogenic risks.
Enhancing the electrochemical properties of a nickel–cobalt-manganese ternary hydroxide electrode using graphene foam for supercapacitors applications
Authors: Kitenge V. N. , Oyedotun K. O. , Fasakin O. , Tarimo D. J. , Sylla N. F. , Van Heerden X. , Manyala N.
Published: March 2021

This study has investigated the effect of the incorporation of graphene foam (GF) into the matrix of a ternary transition-metals hydroxide containing nickel, cobalt, and manganese for optimal electrochemical performances as electrodes for supercapacitors applications. An adopted simple, low-cost co-precipitation synthesis method involved the loading a mass of the ternary metal hydroxides (NiCoMn-TH) onto various GF mass loading so as to find ints effect on the electrochemical properties of the hydroxides. Microstructural and chemical composition of the various composite materials were investigated by employing scanning/transmission electron microscopy (SEM/TEM), x-ray diffraction (XRD), Raman spectroscopy, and N2physisorption analysis among others. Electrochemical performances of the NiCoMn-TH/200 mg GF composite material evaluated in a three-electrode system using 1 M KOH solution revealed a maximum specific capacity around 178.6 mAh g−1compared to 76.2 mAh g−1recorded for the NiCoMn-TH pristine material at a specific current of 1 A g−1. The best mass loading of GF nanomaterial (200 mg GF), was then utilised as a positive electrode material for the design of a novel hybrid device. An assembled hybrid NiCoMn-TH/200 mg GF//CSDAC device utilizing the NiCoMn-TH/200 mg GF and activated carbon derived from the cocoa shell (CSDAC) as a positive and negative electrode, respectively, demonstrated a sustaining specific capacity of 23.4 mAh g−1at a specific current of 0.5 A g−1. The device also yielded sustaining a specific energy and power of about 22.32 Wh kg−1and 439.7 W kg−1, respectively. After a cycling test of over 15,000 cycles, the device could prove a coulombic efficiency of ~ 99.9% and a capacity retention of around 80% within a potential range of 0.0–1.6 V at a specific current of 3 A g−1. These results have demonstrated the prodigious electrochemical potentials of the as-synthesized material and its capability to be utilized as an electrode for supercapacitor applications.
A Gravity Assist Mapping Based on Gaussian Process Regression
Authors: Liu Yuxin , Noomen Ron , Visser Pieter
Published: March 2021

We develop a Gravity Assist Mapping to quantify the effects of a flyby in a two-dimensional circular restricted three-body situation based on Gaussian Process Regression (GPR). This work is inspired by the Keplerian Map and Flyby Map. The flyby is allowed to occur anywhere above 300 km altitude at the Earth in the system of Sun-(Earth+Moon)-spacecraft, whereas the Keplerian map is typically restricted to the cases outside the Hill sphere only. The performance of the GPR model and the influence of training samples (number and distribution) on the quality of the prediction of post-flyby orbital states are investigated. The information provided by this training set is used to optimize the hyper-parameters in the GPR model. The trained model can make predictions of the post-flyby state of an object with an arbitrary initial condition and is demonstrated to be efficient and accurate when evaluated against the results of numerical integration. The method can be attractive for space mission design.
Multiple domains of functioning in older adults during the pandemic: design and basic characteristics of the Longitudinal Aging Study Amsterdam COVID-19 questionnaire
Authors: Hoogendijk Emiel O. , van der Horst Marleen H. L. , Poppelaars Jan , van Vliet Majogé , Huisman Martijn
Published: March 2021

The Longitudinal Aging Study Amsterdam (LASA) is an ongoing cohort study among older adults in the Netherlands. Respondents are usually interviewed approximately every 3 years. Because of the exceptional situation of the COVID-19 pandemic, it was decided to add an extra assessment in between, consisting of a postal/digital questionnaire with measures assessing the impact of the COVID-19 situation, as well as a selection of measures from regular LASA measurement cycles covering the physical, social and mental domains. In total, 1128 LASA respondents aged 62–102 years provided data, just after the first wave of the pandemic in 2020. This paper describes the methods and design of the LASA COVID-19 questionnaire, as well as the basic characteristics of the sample, including an overview of impactful situations experienced by older adults during the first months of the pandemic. The data of the questionnaire may be used to study the impact of the COVID-19 pandemic on multiple domains of functioning in older adults.
Novel Approach to Improve the Optical Performance by Machining Process Without Surface Finishing
Authors: Park June Gyu , Lee Dong-Ho , Kim Hong-Seung , Yeo Woo-Jong , Jeon Minwoo , Bae Ji Yong , Kim Dong Uk , Lee Kye-Sung , Kim Geon-Hee , Chang Ki Soo , Kim I Jong
Published: March 2021

With the increase in dimensions of optical elements in addition to ever rising demand for aspherical optics, the millimeter-scale periodic waviness that is naturally produced by machining (such as diamond turning) process in precision optical engineering has been one of the most crucial issues in the development of high surface quality optical elements. Even an extremely small waviness can affect the laser beam profile significantly through interference caused by Bragg scattering. This paper presents a novel method for improving a laser beam profile by utilizing the characteristics of Bragg scattering without requiring established final surface finishing processes such as optical polishing. By engraving an artificial periodic structure with a period of a few hundred microns, the Bragg scattering angle that influences the formation of interference fringes in the laser beam profile was drastically enlarged. Consequently, the quality of the beam profile was improved at a propagation distance where the 0th and 1st (− 1st) order beam modes are spatially separated, only by diamond turning machining without the surface finishing process. In addition, this approach represents an important contribution to green technology, which seeks energy saving and waste reduction in the optical surface manufacturing process.
Patterns of Relational Framing in Executive Function: An Investigation of the Wisconsin Card Sorting Test
Authors: Tyrberg Mårten J , Parling Thomas , Lundgren Tobias
Published: March 2021

Executive function (EF) is a concept widely used to describe higher order cognitive functioning. However, the concept seems to lack a precise definition upon which even experts in the area can agree. Examples of existing definitions describe EF as capacities for independent self-serving behavior and aspects of working memory, planning and organizational skills. It has been argued that the definition of EF is too imprecise, in terms of informing effective interventions. To possibly understand the range of behaviors termed EF in a more workable way, we administered a well-known computerized test (the Wisconsin Card Sorting Test; WCST) of EF to a sample of normal functioning participants (n = 11). During administration, they were asked questions about their ways of thinking. Transcriptions of questions and answers were analyzed in search of common patterns, using a behavioral theory of language and cognition (relational frame theory; RFT). The analysis suggested that a specific relationship between deictic and temporal framing, on the one hand, and coordination and spatial framing, on the other, was in effect when participants performed well on the WCST. At critical time points during the test (i.e., when need for EF was arguably most acute), deictic and temporal framing dominated participants’ behavior, whereas coordination and spatial framing were used relatively less.
Alleviating the Cold Start Problem in Adaptive Learning using Data-Driven Difficulty Estimates
Authors: van der Velde Maarten , Sense Florian , Borst Jelmer , van Rijn Hedderik
Published: March 2021

An adaptive learning system offers a digital learning environment that adjusts itself to the individual learner and learning material. By refining its internal model of the learner and material over time, such a system continually improves its ability to present appropriate exercises that maximise learning gains. In many cases, there is an initial mismatch between the internal model and the learner’s actual performance on the presented items, causing a “cold start” during which the system is poorly adjusted to the situation. In this study, we implemented several strategies for mitigating this cold start problem in an adaptive fact learning system and experimentally tested their effect on learning performance. The strategies included predicting difficulty for individual learner-fact pairs, individual learners, individual facts, and the set of facts as a whole. We found that cold start mitigation improved learning outcomes, provided that there was sufficient variability in the difficulty of the study material. Informed individualised predictions allowed the system to schedule learners’ study time more effectively, leading to an increase in response accuracy during the learning session as well as improved retention of the studied items afterwards. Our findings show that addressing the cold start problem in adaptive learning systems can have a real impact on learning outcomes. We expect this to be particularly valuable in real-world educational settings with large individual differences between learners and highly diverse materials.
Polar and Helical Isomorphous Crystals of Proline Derivatives: Influence of a Fluorine Atom on the Electric Susceptibility
Authors: Baillargeon Pierre , Seidler Tomasz , Champagne Benoît , Soldera Armand
Published: March 2021

Two novel nonlinear optical isomorphous crystals of proline derivatives with alkyne functionality have been obtained (Boc-L-ProNH(CH2)2CCH and Boc-cis-4-fluoro-L-ProNH(CH2)2CCH). Both derivatives, which differ only by the substitution of a H atom to a F atom, adopt the same polar and columnar right-handed helix arrangement in the crystalline state. In addition, adjacent polar helical columns all point in the same direction, thus generating a macrodipole and a crystalline system conducive for second harmonic generation (SHG) properties. This isomorphous crystal system constitutes an interesting tool to study the effect of the fluorine atom on the dipole moment and on the first hyperpolarizability. Starting from the PBC optimized geometries of the crystals, the macroscopic second-order nonlinearity, χ(2), of the newly synthesized crystals has been estimated by quantum chemical calculations. These χ(2) responses are of the same order of magnitude as those of inorganic proline derivatives while smaller than those observed in crystals of push–pull π-conjugated molecules.

Graphic Abstract
An assessment on the inner lining need for a large-span tunnel (a case from Turkey, Akyazı Tunnel, Trabzon)
Authors: Aygar Ebu Bekir , Gokceoglu Candan
Published: March 2021

Stability of large underground structures depends on not only rock mass conditions but also excavation stages and support systems. In addition, complexity of geological conditions and interaction of excavation with in situ conditions affect the performance of design. The Akyazı tunnel (Trabzon, Turkey) is 2478 m long and was designed as 3 lanes and double tubes, and the number of lanes at the junction part increases to 5. Tunnel cross-sectional area from the Akyazı tunnel reaches 3 lanes and 150 m2 to 5 lanes and 438 m2 gradually. The width of the tunnel at the junction point reaches to 31 m. In this study, the necessity of inner lining concrete in tunnels excavated in good rock mass conditions is assessed and the results of the analyses are discussed. The inner lining concrete increases the cost of tunnel construction, as well as extending the construction period. With the procedure followed in the Akyazı tunnel, the top heading part of the tunnel was constructed without inner lining. No stability and drainage problem have not been encountered for 4 years. Currently, the tunnel construction was completed successfully, and the tunnel was opened to traffic. Consequently, the excavation stages, support systems described, and especially inner lining necessities discussed in this study may be applicable for extremely large tunnel sections.
New Dates and Carbon Isotope Assays of Purported Middle Woodland Maize from the Icehouse Bottom and Edwin Harness Sites
Authors: Simon Mary L. , Hollenbach Kandace D. , Redmond Brian G.
Published: March 2021

Accelerated mass spectrometry (AMS) and carbon isotope analyses provide strong tandem methodologies used by archaeologists to evaluate and reevaluate the histories of maize use in the Midwest. In this article, we present newly obtained AMS dates and carbon isotope assays of alleged maize samples from the Icehouse Bottom (40MR23) and Edwin Harness sites (22RO33). Based on original studies, samples were thought to date to the Middle Woodland period (ca. 300 BC–AD 400). The results show that samples either were not maize or date to post-AD 900. As of this finding, there are no longer any securely dated Middle Woodland macrobotanical remains of maize from the Eastern Woodlands of North America.
Problems and Overcoming Methods of Emergency Medicine Specialists Working at Border Points
Authors: Yılmaz Sarper
Published: March 2021

Objectives:

Emergency medicine specialists working in the Republic of Turkey Ministry of Health public hospitals are assigned voluntarily or compulsorily along the Turkey-Syria borderline due to the operational conditions. In accordance with this study’s purpose, methods and overcoming problems of emergency medical specialists working at border points are addressed.

Materials and Methods:

The case study design is used as a qualitative research method in this research. Within the context of content analysis, 2 themes and 7 subthemes are created in line with the identified subproblems. Under these themes, the problems experienced by physicians, solutions to them, and recommendations for physicians who will start to work along the borderline are presented with codes and anecdotes.

Results:

The results of the study indicate that the problems experienced by physicians working in the border regions are centred on environmental conditions, operation of the system, and security issues. The methods for coping with such problems focus on effective communication and the support of colleagues. The basic suggestion of the participating physicians to improve the system is that the emergency medical specialists who run the border service should undergo training that can be useful for adapting to war conditions. Despite experiencing personal and familial challenges, these physicians express that they feel happy and at peace in their work.

Conclusion:

For the physicians assigned to work along the borderlines, high efficiency can be obtained if they are given preassignment training and provided with effective personal communication combined with personal rights adjustment.
Social Vulnerability and Access of Local Medical Care During Hurricane Harvey: A Spatial Analysis
Authors: Rickless David S. , Wilt Grete E. , Sharpe J. Danielle , Molinari Noelle , Stephens William , LeBlanc Tanya Telfair
Published: March 2021

Objectives:

When Hurricane Harvey struck the coastline of Texas in 2017, it caused 88 fatalities and over US $125 billion in damage, along with increased emergency department visits in Houston and in cities receiving hurricane evacuees, such as the Dallas-Fort Worth metroplex (DFW).

This study explored demographic indicators of vulnerability for patients from the Hurricane Harvey impact area who sought medical care in Houston and in DFW. The objectives were to characterize the vulnerability of affected populations presenting locally, as well as those presenting away from home, and to determine whether more vulnerable communities were more likely to seek medical care locally or elsewhere.

Methods:

We used syndromic surveillance data alongside the Centers for Disease Control and Prevention Social Vulnerability Index to calculate the percentage of patients seeking care locally by zip code tabulation area. We used this variable to fit a spatial lag regression model, controlling for population density and flood extent.

Results:

Communities with more patients presenting for medical care locally were significantly clustered and tended to have greater socioeconomic vulnerability, lower household composition vulnerability, and more extensive flooding.

Conclusions:

These findings suggest that populations remaining in place during a natural disaster event may have needs related to income, education, and employment, while evacuees may have more needs related to age, disability, and single-parent household status.
Longitudinal Study of Hurricane Preparedness Behaviors: Influence of Collective Efficacy
Authors: Mash Holly B Herberman , Fullerton Carol S , Morganstein Joshua C , Vance Mary C , Wang Leming , Liu Alexander G , Mullins-Hussain Britany , Ursano Robert J
Published: March 2021

Objective:

Community characteristics, such as collective efficacy, a measure of community strength, can affect behavioral responses following disasters. We measured collective efficacy 1 month before multiple hurricanes in 2005, and assessed its association to preparedness 9 months following the hurricane season.

Methods:

Participants were 631 Florida Department of Health workers who responded to multiple hurricanes in 2004 and 2005. They completed questionnaires that were distributed electronically approximately 1 month before (6.2005-T1) and 9 months after (6.2006-T2) several storms over the 2005 hurricane season. Collective efficacy, preparedness behaviors, and socio-demographics were assessed at T1, and preparedness behaviors and hurricane-related characteristics (injury, community-related damage) were assessed at T2. Participant ages ranged from 21-72 (M(SD) = 48.50 (10.15)), and the majority were female (78%).

Results:

In linear regression models, univariate analyses indicated that being older (B = 0.01, SE = 0.003, P < 0.001), White (B = 0.22, SE = 0.08, P < 0.01), and married (B = 0.05, SE = 0.02, p < 0.001) was associated with preparedness following the 2005 hurricanes. Multivariate analyses, adjusting for socio-demographics, preparedness (T1), and hurricane-related characteristics (T2), found that higher collective efficacy (T1) was associated with preparedness after the hurricanes (B = 0.10, SE = 0.03, P < 0.01; and B = 0.47, SE = 0.04, P < 0.001 respectively).

Conclusion:

Programs enhancing collective efficacy may be a significant part of prevention practices and promote preparedness efforts before disasters.
Reasoning Without the Conjunction Closure
Authors: Kowalewska Alicja
Published: March 2021

Some theories of rational belief assume that beliefs should be closed under conjunction. I motivate the rejection of the conjunction closure, and point out that the consequences of this rejection are not as severe as it is usually thought. An often raised objection is that without the conjunction closure people are unable to reason. I outline an approach in which we can – in usual cases – reason using conjunctions without accepting the closure in its whole generality. This solution is based on the notion of confidence levels, which can be defined using probabilities. Moreover, on this approach, reasoning has a scalable computational complexity adaptable to cognitive abilities of both rationally bounded and perfectly rational agents. I perform a simulation to assess its error rate, and compare it to reasoning with conjunction closure.
The Next Generation of International Law: Space, Ice, and the Cosmolegal Proposal
Authors: Cirkovic Elena
Published: March 2021

With the increasing environmental degradation in spaces most affected by climate change such as the Arctic, and the extension of anthropogenic environmental problems even into the Earth’s orbit, international law is confronted with some unprecedented challenges. Much of the legal dialogue surrounding this question is taking place in the abstract, such that there are no exact proposals for methodological and practical applications in lawmaking. In this Article, I argue that current governance relevant to the Arctic and outer space precedes an understanding of these spaces. Critical posthumanism, and other approaches, point out the continuation of strict boundaries that have been set up between the human body and the environment. International law’s formalist doctrinal deductions exacerbate these boundaries. I propose an approach to lawmaking under a broad term: the cosmolegal. The cosmolegal proposal challenges distinctions between human-made and non-human “laws”—scientific and social laws—and questions the foundational determination of both. The framework I suggest in this Article, therefore, requires a new approximation to accuracy in lawmaking, which could be achieved by greater interdisciplinarity and acceptance of ontological pluralism. This Article is divided into two broader sections. The first section focuses on two environmental problems: A) greenhouse gas (GHG) emissions in the Arctic and B) orbital debris. The second section argues for a different ontology of law and human self-understanding in the context of the unknown. It proposes “cosmolegality” in an attempt to approximate the inclusion and representation of ‘everything considered to be non-human.
Theory of Social Proof and Legal Compliance: A Socio-Cognitive Explanation for Regulatory (Non) Compliance
Authors: Roy Shubhangi
Published: March 2021

Challenging the assumption of perfect legal knowledge, this Article employs social psychology to better understand how individuals make decisions about legal compliance under imperfect information conditions. It adapts the informational aspects of “social influence conception of criminal deterrence” to regulatory compliance at large. However, it conceptualizes social influence as more than just “visible deterrence.” Social Psychology helps us to understand who, how many, and what kind of behaviors constitute adequate social proof to guide an individual’s decision on compliance. Additionally, the interaction of social proof and legal compliance is considered within a dynamic framework in relation to specific rules and across the system. Within this framework, compliance/non-compliance cascades across different rules and can create a perception about legal compliance at large, which in turn guides initial expectations with respect to new laws. Over time, this can create high/low compliance equilibriums within which societies operate. Understanding this informational role that social influence plays in legal compliance can further our understanding of what motivates compliance, the potency of the expressive functions of law in societies operating within different compliance equilibriums, and inform policy discussions on how to improve compliance—both voluntary and through sanction/incentives.
Impact of COVID-19 pandemic on central-line–associated bloodstream infections during the early months of 2020, National Healthcare Safety Network
Authors: Patel Prachi R. , Weiner-Lastinger Lindsey M. , Dudeck Margaret A. , Fike Lucy V. , Kuhar David T. , Edwards Jonathan R. , Pollock Daniel , Benin Andrea
Published: March 2021

Data reported to the Centers for Disease Control and Prevention’s National Healthcare Safety Network (CDC NHSN) were analyzed to understand the potential impact of the COVID-19 pandemic on central-line–associated bloodstream infections (CLABSIs) in acute-care hospitals. Descriptive analysis of the standardized infection ratio (SIR) was conducted by location, location type, geographic area, and bed size.
WHEN ARE THERE ENOUGH PROJECTIVE PERVERSE SHEAVES?
Authors: CIPRIANI ALESSIO , WOOLF JON
Published: March 2021

LetXbe a topologically stratified space,pbe any perversity onXandkbe a field. We show that the category ofp-perverse sheaves onX, constructible with respect to the stratification and with coefficients ink, is equivalent to the category of finite-dimensional modules over a finite-dimensional algebra if and only ifXhas finitely many strata and the same holds for the category of local systems on each of these. The main component in the proof is a construction of projective covers for simple perverse sheaves.