bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Flap Microsurgical Autologous Breast Reconstruction
Authors: Steele Thomas N. , Teotia Sumeet S. , Haddock Nicholas T.
Published: September 2024

Microsurgical autologous breast reconstruction (MABR) remains the gold standard technique of breast reconstruction, providing a durable, natural, and aesthetically pleasing result. However, some patients may not be candidates for a traditional deep inferior epigastric perforator (DIEP) flap, either due to abdominal tissue paucity, the need for higher-volume reconstruction, or prior surgical procedures. In these patients, alternative flaps must be considered to achieve the optimal result. Such configurations include the conjoined (or double pedicle) DIEP flap, and alternative flaps such as the lumbar artery perforator (LAP) and profunda artery perforator (PAP) flaps, which can be combined in a stacked fashion. By combining multiple flaps in a conjoined or stacked fashion, breast reconstruction can be optimized to fulfill the three critical components of breast reconstruction in restoring the skin envelope, breast footprint, and conus shape. When harvesting multiple flaps, the surgical sequence of events must be meticulously planned to ensure an efficient and successful operation. Preoperative imaging can aid the surgeon in identifying the ideal perforator, assess for side branches for possible intra-flap anastomoses, expedite the operative time, and decrease intraoperative complications. Reconstructive surgeons should be familiar with the variety of configurations with conjoined and/or stacked flaps to address patient-specific reconstructive needs.
Visualization of the Postoperative Position of the Hydrus® Microstent Using Automatic 360° Gonioscopy
Authors: Zimmermann Julian Alexander , Kleemann Sarah , Storp Jens Julian , Weich Cedric , Merté Ralph-Laurent , Eter Nicole , Brücher Viktoria Constanze
Published: September 2024

Introduction: Glaucoma, one leading cause of irreversible vision loss worldwide, is primarily caused by elevated intraocular pressure (IOP). Recently, minimally invasive glaucoma surgeries (MIGSs) have become popular due to their shorter surgical times, tissue-sparing nature, and faster recovery. One such MIGS, the Hydrus® nickel–titanium alloy Microstent, helps lower IOP by improving aqueous humor outflow. The NIDEK GS-1 automated 360° gonioscope provides advanced imaging of the chamber angle for evaluation and documentation. The aim of this study was to test automated 360° gonioscopy for the detection of postoperative positional variations after Hydrus® Microstent implantation. This study is the largest to date to evaluate post-op positioning of the Hydrus® Microstent using the NIDEK GS-1. Materials and Methods: This study analyzed postoperative outcomes and stent location in eyes diagnosed with mild to moderate glaucoma that underwent Hydrus® Microstent implantation with or without phacoemulsification. Patients with prior IOP-lowering surgery or vitrectomy were excluded. Analyses of the postoperative Hydrus® Microstent position were based on the evaluation of automated 360° gonioscopy images. Results: Twenty-three eyes were included in the study, and all showed a reduction in IOP and a decrease in antiglaucomatous drop use postoperatively. Postoperative gonoscopic images showed variations in implant position. In all cases, the proximal inlet was clearly visible in the anterior chamber. The degree of protrusion into the anterior chamber was variable. The distal tip of the stent was visible behind the trabecular meshwork in Schlemm’s canal in five cases, in the anterior chamber in one case, and not visible in seven cases. In no case did postoperative alterations in the position of the implant lead to explantation. Conclusions: This study demonstrated that the Hydrus® Microstent can effectively lower IOP even in the presence of postoperative positional variations. Automated 360° gonioscopy was found to be a useful tool to verify and document the postoperative position of the implant. Positional changes did not require device explantation in any of the cases evaluated.
BD Vacutainer™ Urine Culture & Sensitivity Preservative PLUS Plastic Tubes Minimize the Harmful Impact of Stressors Dependent on Temperature and Time Storage in Uropathogenic Bacteria
Authors: Treviño Samuel , Ramírez-Flores Eduardo , Cortezano-Esteban Steffany , Hernández-Fragoso Hugo , Brambila Eduardo
Published: September 2024

Background: Urinary tract infection is a worldwide health problem. According to the Clinical Laboratory Improvement Amendments and the European Urinalysis Guideline, urine samples should be tested within 2 h of collection. Thus, using chemical preservatives that guarantee the pre-analytical conditions is a practical tool. However, the effects of temperature and storage time as uropathogenic bacteria stressors are unclear. Methods: Gram-negative and -positive ATTC strains, E. coli, P. mirabilis, E. faecalis, and S. aureus, were used in this study. Strains in liquid media were stored at 4, 25, and 37 °C for 0, 2, 12, 24, and 48 h in tubes with and without preservatives. Then, reactive oxygen species (ROS) levels, viable but non-culturable bacteria (VBNC), and bacteria growth were analyzed. Results: A high ROS level was associated with the presence of VBNC and dead bacteria with low CFU counts, but a low ROS level increased the CFU number, depending on temperature and storage time in tubes without preservatives (boric acid, sodium borate, and formate). The BD Vacutainer™ Urine Culture & Sensitivity Preservative PLUS Plastic Tubes (C&S-PP) prevent this ROS increase, maintaining the CFU number for longer. Conclusions: C&S-PP tubes minimize the stressor effects (temperature and time storage) on uropathogenic bacteria when stored, improving the pre-analytical conditions of cultures realized by the clinical laboratory.
Prospective Analysis of the Effectiveness of Targeted Botulinum Toxin Type A Injection Using an Ultrasound-Guided Single-Point Injection Technique for Lower Face Contouring
Authors: Ryoo Hyun-Jung , Kwon Ho , Choi Jae-Seon , Sohn Bo-Seong , Yoo Ja-Young , Shim Hyung-Sup
Published: September 2024

Background: Botulinum toxin type A (BoNT-A) injection is widely used for masseter hypertrophy. Traditional BoNT-A injection methods often incorporate landmark-guided blind injections, which approximate the shape of the masseter muscle inject across various points. Conversely, ultrasound (US)-guided injection techniques offer real-time visualization and dynamic monitoring, enhancing accuracy. Patients and Methods: 50 patients who underwent BoNT-A injections were included in this trial. One on the face side received a landmark-guided injection, and the other side was treated with a US-guided injection. Initial and post-procedure measurements of muscle thickness at the upper, middle, and lower regions were collected using ultrasound. Results: Both methods led to a significant reduction in muscle thickness one month after injection. In the upper area, the absolute difference in muscle thickness between the two methods was observed as a mean ± standard deviation (SD) value of 0.37 ± 0.0314 (p < 0.0001), indicating a superior effect with US-guided injection. Similarly, in the middle area, the mean ± SD difference was 0.41 ± 0.0608 (p < 0.0001) and in the lower area, the mean ± SD difference was 0.24 ± 0.0134 (p = 0.0004). Conclusions: This study demonstrated that the US-guided single-point injection technique is a more effective and accurate method for BoNT-A injection compared to the conventional method.
Contemporary Outcomes of Infrainguinal Vein Bypass Surgery for Chronic Limb-Threatening Ischaemia: A Two-Centre Cross-Sectional Study
Authors: Lovelock Thomas , Randhawa Sharan , Wells Cameron , Dean Anastasia , Khashram Manar
Published: September 2024

Background/Objectives: Chronic limb-threatening ischaemia (CLTI) is a significant life and limb-threatening condition. Two recent seminal trials, BEST-CLI and BASIL-2, have provided seemingly conflicting results concerning the optimal treatment modality for patients with CLTI. We sought to investigate the outcomes of patient undergoing infrainguinal bypass at two centres in Aotearoa New Zealand. Methods: A cross-sectional retrospective review of all patients who underwent infrainguinal bypass grafting for CLTI at Auckland City Hospital and Waikato Hospital between January 2020 and December 2021 was performed. The primary outcome was a composite of death, above-ankle amputation, and major limb reintervention. The secondary outcome was minor limb reintervention. Kaplan–Meier survival analysis was performed to determine time to the primary and secondary endpoints. Demographic factors were examined using the log-rank test to examine the effect on the outcome. Results: One hundred and nineteen patients who underwent infrainguinal bypass for CLTI in the study period were identified. Of these, 93 patients had a bypass with ipsilateral or contralateral GSV. The median follow-up time was 1.85 years. The most common indication for surgery was tissue loss (69%, n = 63), with the most common distal bypass target being the below-knee popliteal artery (45%, n = 41). The primary composite outcome occurred in 42.8% of the cohort (n = 39). Death was the most common component of the primary outcome (26%, n = 24). Male sex (HR 0.48, 95% CI 0.26–0.88, p = 0.018) and statin use (HR 0.49, 95% CI 0.24–0.98, p = 0.044) were independent predictors of protection from the composite outcome on multivariate analysis. Dialysis dependence (HR 3.32, 95% CI 1.23–8.99, p = 0.018) was an independent predictor for patients meeting the composite outcome. Conclusions: This study’s results are consistent with the published outcomes of BEST-CLI. The patient cohorts examined, anatomical disease patterns, and conduit use may explain some of the differences observed between this study, BEST-CLI and BASIL-2. Further work is required to define the specific patient populations who will benefit most from an open surgical or endovascular first approach to the management of CLTI.
Potential Effects of Lifelong Team Handball and Football Training and Nutritional Habits on Bone Health and Body Composition in Elderly Women
Authors: Martone Domenico , Vigh-Larsen Jeppe Foged , Vitucci Daniela , Larsen Malte Nejst , Randers Morten Bredsgaard , Olesen Jens Lykkegaard , Mohr Magni , Mancini Annamaria , Krustrup Peter , Buono Pasqualina
Published: September 2024

Background/Objectives: The aim of this study was to evaluate the effects of lifelong team handball/football training on regional bone health and body composition in elderly women. Methods: Seventeen elderly women team handball/football players (65.9 ± 5.7 years) and twenty-one untrained age-matched women (controls) (67.7 ± 5.1 years) participated. Whole-body and regional dual-energy X-ray absorptiometry scans of arms, legs, and lower spine (L1–L4) were performed. Results: We observed 8% and 9% higher bone mineral density (BMD) and bone mineral content (BMC), respectively, at the whole-body level and in the legs and 11.5% higher BMC in the legs in team handball/football players compared to untrained age-matched controls (p < 0.05). Higher total and leg lean body mass (p < 0.05), along with lower total body fat percentage (p < 0.05) and higher T- and Z-scores, markers of fragility risk fracture (0.294 ± 1.461 vs. −0.538 ± 1.031; 1.447 ± 1.278 vs. 0.724 ± 0.823, respectively), were also found in team handball/football players compared to controls (p < 0.05). No significant differences in nutritional habits were observed between groups. Conclusions: Our study suggest that the beneficial effects of lifetime handball/football practice on bone preservation in elderly women occur independently from nutritional intake, which emphasize the potential role of team sports in osteoporosis prevention. Future studies should focus on the cofounding factors and causative mechanisms mediated by team sport practice in osteoporosis prevention.
Utilization of Healthcare Services in Patients with Chronic Diseases under 18 Years Old: Differences and Contributing Factors
Authors: Barrio-Cortes Jaime , Benito-Sánchez Beatriz , Sánchez-Ruano Raquel , García-Hernández César Alfonso , Beca-Martínez María Teresa , Martínez-Cuevas María , Castaño-Reguillo Almudena , Muñoz-Lagos Cristina
Published: September 2024

Pediatric patients with chronic conditions frequently have unmet care needs, make extensive use of healthcare services, and often encounter fragmented, non-centered care. This study aimed to analyze the differences in the utilization of primary care (PC) and hospital care (HC) services by these patients according to sex, age, and complexity and to identify associated factors. A cross-sectional study was conducted in a basic health area of Madrid, including patients under 18 years. Among these patients, 15.7% had ≥1 chronic disease, 54.1% were male, the average age was 9.5 years, 3.5% had complexity, and 11.3% had multimorbidity. The mean number of contacts/year with the healthcare system was 9.1, including 8.3 contacts/year with PC (4.9 with pediatricians and 1.9 with nurses) and 0.8 contacts/year with HC (0.8 in external consultations and 0.01 hospitalizations). The factors associated with PC utilization were complexity; female sex; European origin; and diseases like asthma, epilepsy, stroke, recurrent urinary infection, attention deficit hyperactivity disorder, and anxiety, while older age was negatively associated. Thyroid disorders were significantly associated with HC utilization. These findings could help guide the design of optimized pediatric patient-centered care approaches to coordinate care across healthcare services and reduce high healthcare utilization, therefore improving the healthcare outcomes and quality of life for these patients.
Behavioral Interactions and Mate Compatibility Influence the Reproductive Success of New England Cottontails (Sylvilagus transitionalis) in a Conservation Breeding Program
Authors: Petit Hannah , Perrotti Louis , Richard Justin T.
Published: September 2024

Wild populations of New England cottontails (NECs, Sylvilagus transitionalis) are declining and occupy a small proportion of their historic range. To conserve this species, wild-caught cottontails participate in a reintroduction breeding program. To increase the program’s productivity, this study described breeding behavior in pairings with (n = 3 pairings) and without (n = 9 pairings) reproductive success. Females were paired with two males consecutively and behaviors were recorded using 24 h continuous video footage. Activity peaked between 19:00 and 06:00. Copulation was only observed in successful pairings, and the gestation period was 31 days. Successful pairings had a significantly higher rate of follows (p < 0.001) and a lower rate of dashes (p < 0.0001) compared to unsuccessful pairings. Females had significantly higher rates of charge (p < 0.0005), chase (p < 0.0003), and dash (p < 0.0016) than males. Males had higher rates of follow (p < 0.005) than females. Males and females altered their behavior in the presence of different potential mates, suggesting that mate compatibility may influence breeding program productivity. This study significantly expands the understanding of NEC breeding behavior and is applicable to the management of this imperiled species living at low densities in fragmented landscapes.
Green Belt Legislation Regulation: Comparative Legal Research
Authors: Lisina Natalia , Ushakova Aleksandra , Ivanova Svetlana
Published: September 2024

Recently, legislative acts on the protection of the green belt have been increasingly adopted in various states. Using the legislation examples of the United Kingdom, the Canadian province of Ontario, and Russia, we have identified public relations that can be the subject of regulation of such legislation. Based on the analysis of typical legal conflicts, the problem areas which need the most attention of the legislator have been identified. The methods of differentiation of the legal regime for various areas within the green belt are investigated, taking into account their geographical features and specific management goals. The most promising areas for legal regulation that require the increased attention of legislators speak to the establishment of the procedures and criteria for excluding land plots from the green belt, the regulation of village development processes within the green belt, the establishment of a comprehensive list of agricultural types of permitted use, and the establishment of the procedure for the development of specialized plans or strategies for the use and protection of the green belt. The article offers solutions to these issues. The methodology of comparative law, including the functional method, was used in the study.
Off-Label Uses of Abrocitinib: Review of Emerging Therapeutic Applications beyond Atopic Dermatitis
Authors: Mitroi George G. , Mitroi George F. , Ică Oana Maria , Anghelina Florin , Ciolofan Mircea Sorin , Mitroi Mihaela Roxana
Published: September 2024

Abrocitinib, an oral small-molecule Janus Kinase 1 (JAK1) inhibitor, is primarily approved for treating moderate-to-severe atopic dermatitis (AD) in adults and adolescents aged 12 and older. This review examines the emerging off-label uses of Abrocitinib. We identified 37 papers reporting on the use of Abrocitinib in various conditions other than AD. The most commonly reported uses were for vitiligo, prurigo nodularis, and hand eczema, with 12 cases each. There were also 10 cases of lichen sclerosus and chronic pruritus of unknown origin and 5 cases each of pityriasis rubra pilaris alopecia areata. Additionally, erythematotelangiectatic rosacea and steroid-induced rosacea were reported in four cases each. Other conditions treated with Abrocitinib were noted, but these mostly had only one or two reported cases. Interestingly, out of the 103 patients reviewed, all studies reported favorable clinical outcomes and satisfactory results, with the exception of one isolated case where Abrocitinib was used to treat erythematotelangiectatic rosacea.
Analysis of Wavelet Coherence in Calf Agonist-Antagonist Muscles during Dynamic Fatigue
Authors: Ni Xindi , Ieong Loi , Xiang Mai , Liu Ye
Published: September 2024

Dynamic muscle fatigue during repetitive movements can lead to changes in communication between the central nervous system and peripheral muscles. This study investigated these changes by examining electromyogram (EMG) characteristics from agonist and antagonist muscles during a fatiguing task. Twenty-two healthy male university students (age: 22.92 ± 2.19 years) performed heel raises until fatigue. EMG signals from lateral gastrocnemius (GL) and tibialis anterior (TA) muscles were processed using synchrosqueezed wavelet transform (SST). Root mean square (RMS), mean frequency (MF), power across frequency ranges, wavelet coherence, and co-activation ratio were computed. During the initial 80% of the task, RMS and EMG power increased for both muscles, while MF declined. In the final 20%, GL parameters stabilized, but TA showed significant decreases. Beta and gamma intermuscular coherence increased upon reaching 60% of the task. Alpha coherence and co-activation ratio remained constant. Results suggest that the central nervous system adopts a differentiated control strategy for agonist and antagonist muscles during fatigue progression. Initially, a coordinated “common drive” mechanism enhances both muscle groups’ activity. Later, despite continued increases in muscle activity, neural-muscular coupling remains stable. This asynchronous, differentiated control mechanism enhances our understanding of neuromuscular adaptations during fatigue, potentially contributing to the development of more targeted fatigue assessment and management strategies.
Synthesis of Novel Sulfonamide Derivatives Featuring 1-(Methylsulfonyl)-4-(2,3,4-Trimethoxybenzyl)Piperazine Core Structures
Authors: Ivanov Iliyan , Manolov Stanimir , Bojilov Dimitar , Dimitrova Diyana , Nedialkov Paraskev
Published: September 2024

Herein we report the synthesis of three novel sulfonamide derivatives of trimetazidine—medication primarily used to treat angina pectoris. The new compounds have been fully characterized with their melting point, 1H- and 13C-NMR, UV, and mass spectrometry. The collected data confirm the successful synthesis and structural integrity of the new molecules.
The Impact of Dynamic Effects on the Results of Non-Destructive Falling Weight Deflectometer Testing
Authors: Tutka Paweł , Nagórski Roman , Złotowska Magdalena
Published: September 2024

The article investigates the impact of applying a dynamic computational model that considers inertia forces on pavement deflections under rapidly changing loads over time. This study is particularly relevant to the modelling of falling weight deflectometer (FWD) testing. Initially, the article examines the deflection values obtained from computational models under loads with varying frequencies. In this context, considering inertia forces was significant for load durations shorter than 0.04 s. In such cases, the results of static and dynamic analyses differed considerably. One application of FWD measurement results is determining the stiffness moduli of pavement layers using backcalculation. The study explored the impact of incorporating inertia forces into the pavement model on the estimated values of stiffness moduli obtained via backcalculation. The results revealed differences of several percent between the stiffness moduli calculated using dynamic and static numerical models. Subsequently, the key pavement deformations and fatigue life were determined using the obtained moduli. Again, significantly different results were observed between dynamic and static cases. Based on these findings, it can be concluded that dynamic effects should not be ignored when using FWD testing for backcalculation. Additionally, the article addresses the sensitivity of backcalculation results, which is crucial for the accurate interpretation of the obtained data.
Cork Façades as an Innovative and Sustainable Approach in Architecture: A Review of Cork Materials, Properties and Case Studies
Authors: Miranda Isabel , Pereira Helena
Published: September 2024

Façades give the first impression of a structure, reflecting the overall aesthetic appeal, architectural styles, cultural influences, and technological advancements. Emphasis on sustainability is increasing, with a shift towards eco-friendly and energy-saving materials, triggered by decreasing the environmental impact of construction. Cork is a green competitive material for various engineering and design applications due to its biological formation, sustainable production and a portfolio of properties including low density, impermeability, viscoelastic behaviour and high thermal insulation that derive from its cellular and chemical features. This work presents cork materials used in building façades and their properties, also giving information on cork production and processing into cork-based products as a review of the existing published research, while also identifying knowledge gaps and further research needed. Historical examples of cladding of constructions with raw cork are given, while the contemporary innovative use of cork façades was triggered by some designs of well-known architects with outdoor application of expanded cork agglomerates. Examples of different historical and contemporary constructions were assembled and critically assessed by the authors. The aim is to give integrated information of cork as a natural, renewable and sustainable material to raise the interest of designers, architects and engineers to explore cork, blending aesthetics with environmental responsibility, targeting a more sustainable and resilient built environment.
Texture of Hot-Compressed Metastable β-Titanium Alloy Ti5321 Studied by Neutron Diffraction
Authors: Gu Bin , Chekhonin Paul , Chulist Robert , Gan Weimin , Skrotzki Werner
Published: September 2024

The textures of the β- and α-phases of the metastable β-titanium alloy Ti5321 after hot deformation were investigated by neutron diffraction. A hot-rolled bar was solutionized in the β-phase field and then hot compressed above and below the β-transus temperature. The initial texture after full recrystallization and grain growth in the β-phase field exhibits a weak cube component {001}<100> and minor {112}<110> and {111}<110> components. After hot compression, a <100> fiber texture is observed, increasing in intensity with compression temperature. Below the β-transus temperature, dynamic recrystallization of the β-phase and dynamic spheroidization of the α-phase interact strongly. The texture of the α-phase is a <11–20> fiber texture, increasing in intensity with decreasing compression temperature. The mechanisms of texture formation during hot compression are discussed.
A Review on Metallurgical Issues in the Production and Welding Processes of Clad Steels
Authors: Giudice Fabio , Missori Severino , Scolaro Cristina , Sili Andrea
Published: September 2024

Carbon and low-alloy steel plates clad with stainless steel or other metals are a good choice to meet the demand for cost-effective materials to be used in many corrosive environments. Numerous technical solutions are developed for the production of clad steel plates, as well as for their joining by fusion welding. For thick plates, a careful strategy is required in carrying out the multiple passes and in choosing the most suitable filler metals, having to take into account the composition of the base metal and the cladding layer. The specificity of the different processes and materials involved requires an adequate approach in the study of the metallurgical characteristics of clad steel, thus arousing the interest of researchers. Focusing mainly on ferritic steel plates clad with austenitic steel, this article aims to review the scientific literature of recent years which deals with both the production and the fusion welding processes. The metallurgical issues concerning the interfaces and the effects of microstructural characteristics on mechanical behaviour and corrosion resistance will be addressed; in particular, the effects on the fusion and thermally affected zones that form during the fusion welding and weld overlay processes will be analysed and discussed.
Research on the Mechanism of Oxygen-Induced Embrittlement Fracturing in Industrial Electrolytic Nickel
Authors: Zhang Han , Sang Chen , Miao Chengpeng , Xu Yangtao , Qiao Jisen , Xia Tiandong
Published: September 2024

In this study, severe cracking occurred during an investigation of the direct hot rolling of industrial electrolytic nickel plates. To determine the cause of hot-rolling cracking, the microstructure phase composition was analyzed through the utilization of various techniques, including optical microscopy, scanning electron microscopy, electron backscattering diffraction, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS) and electron probe micro-analysis. The comparative microstructural analysis took place between specimens heat treated in atmospheric and vacuum environments. The characterization and analysis of the hot-rolled plates considered the crack microstructure and fracture morphology. It was shown that holes appeared along the large angular grain boundaries after annealing at 1100 °C for 8 h. Possible reason: In a high-temperature environment, the decomposition of residual additives in the electrolytic nickel releases oxidizing gases, which oxidizes the grain boundaries. The reaction with carbon diffused into the grain boundaries and produced carbon monoxide gas, which induced holes and severely reduced the grain boundary plasticity. The heat treatment time did not need to be very long for severe grain boundary degradation to occur. After severe cavitation, the electrolytic nickel was severely cracked at grain boundaries cracks due to a shear force, and brittle fractures occurred along grains with very low plasticity.
In Situ Investigation of Tensile Response for Inconel 718 Micro-Architected Materials Fabricated by Selective Laser Melting
Authors: Kyriakidis Ioannis Filippos , Kladovasilakis Nikolaos , Pechlivani Eleftheria Maria , Korlos Apostolos , David Constantine , Tsongas Konstantinos
Published: September 2024

Topology optimization enables the design of advanced architected materials with tailored mechanical properties and optimal material distribution. This method can result in the production of parts with uniform mechanical properties, reducing anisotropy effects and addressing a critical challenge in metal additive manufacturing (AM). The current study aims to examine the micro-tensile response of Inconel 718 architected materials utilizing the Selective Laser Melting Technique. In this context, three novel architected materials, i.e., Octet, Schwarz Diamond (SD), and hybrid Schwarz Diamond and Face Centered Cubic (FCC), were tested in three different relative densities. The specimens were then subjected to uniaxial quasi-static tensile tests to determine their key mechanical properties, including elastic modulus, yield strength, and ultimate tensile strength (UTS), as well as the scaling laws describing the tensile response of each architected material. In situ Scanning Electron Microscopy (SEM) has been performed to observe the structure and grain morphology of the 3D printed specimens along with the phase transitions (elastic, plastic), the crack propagation, and the overall failure mechanisms. The results highlight the effect of the lattice type and the relative density on the mechanical properties of architected materials. Topologically optimized structures presented a 70–80% reduction in overall strength, while the SD and SD&FCC structures presented higher stretching dominated behavior, which was also verified by the n-value range (1–2) extracted from the identification of the scaling laws.
Lifecycle Assessment and Multi-Parameter Optimization of Lightweight Cement Mortar with Nano Additives
Authors: Du Yiying , Korjakins Aleksandrs , Sinka Maris , Pundienė Ina
Published: September 2024

With the growing global concerns regarding sustainable development in the building and construction industries, concentration only on the engineering properties of building materials can no longer meet the requirements. Although some studies have been implemented based on the lifecycle assessment of lightweight cement-based materials, very few attempts have been made pertaining to multi-criteria optimization, especially when fly ash cenospheres are used as lightweight aggregates and nano additives are incorporated as modifying admixtures. This investigation utilized cenospheres as fine aggregates to produce green, sustainable, lightweight cement mortar. Multi-walled carbon nanotubes at 0.05, 0.15, and 0.45% were binarily added, together with 0.2, 0.6, and 1.0% of nano silica to improve the mechanical performance. Strength tests were conducted to measure the flexural and compressive behaviors, combined with a cradle-to-gate lifecycle assessment and direct cost analysis to assess the environmental and economic viability. Integrated indexes and the TOPSIS method were adopted to systematically evaluate the mortar mixes and determine the optimal mix. The outcomes show that nano additives worked synergically to enhance the mechanical properties of the mortars. The utilization of cenospheres effectively reduced environmental impacts and improved economic feasibility. Nano additives significantly affected the sustainability and economic viability; in particular, the utilization of multi-walled carbon nanotubes increased the material costs. To minimize the impact of the price of multi-walled carbon nanotubes, it is proposed to binarily use less expensive nano silica. In the multi-parameter optimization, the mix with 0.05% multi-walled carbon nanotubes and 0.02% nano silica was recommended to be the optimal mix.
The Biocompatibility and the Effect of Titanium and PEKK on the Osseointegration of Customized Facial Implants
Authors: Hong Sung-Ok , Pyo Ju-Yeon , On Sung-Woon , Seo Ja-Yeong , Choi Jin-Young
Published: September 2024

The purpose of this study was to investigate the optimization of computer-aided design/computer-aided manufacturing (CAD/CAM) patient-specific implants for mandibular facial bone defects and compare the biocompatibility and osseointegration of machined titanium (Ma), Sandblasted/Large-grit/Acid-etched (SLA) titanium, and polyetherketoneketone (PEKK) facial implants. We hypothesized that the facial implants made of SLA titanium had superior osseointegration when applied to the gonial angle defect and prevented the senile atrophy of the bone. Histologic findings of the soft-tissue reaction, hard-tissue reaction, and bone–implant contact (BIC (%) of 24 Ma, SLA, and PEKK facial implants at 8 and 12 weeks were investigated. There was no statistical difference in the soft tissue reaction. Bone was formed below the periosteum in all facial implants at 12 weeks and the BIC values were significantly different at both 8 and 12 weeks (p < 0.05). Ma, SLA, and PEKK facial implants are biocompatible with osseointegration properties. SLA can enhance osseointegration and provoke minimal soft tissue reactions, making them the most suitable choice. They provide an excellent environment for bone regeneration and, over the long term, may prevent atrophy caused by an aging mandible. The bone formation between the lateral surface of the facial implant and periosteum may assist in osseointegration and stabilization.
Reduction in Olfactory Discomfort in Inhabited Premises from Areas with Mofettas through Cellulosic Derivative–Polypropylene Hollow Fiber Composite Membranes
Authors: Albu Paul Constantin , Pîrțac Andreia , Motelica Ludmila , Nechifor Aurelia Cristina , Man Geani Teodor , Grosu Alexandra Raluca , Tanczos Szidonia-Katalin , Grosu Vlad-Alexandru , Nechifor Gheorghe
Published: September 2024

Hydrogen sulfide is present in active or extinct volcanic areas (mofettas). The habitable premises in these areas are affected by the presence of hydrogen sulfide, which, even in low concentrations, gives off a bad to unbearable smell. If the living spaces considered are closed enclosures, then a system can be designed to reduce the concentration of hydrogen sulfide. This paper presents a membrane-based way to reduce the hydrogen sulfide concentration to acceptable limits using a cellulosic derivative–propylene hollow fiber-based composite membrane module. The cellulosic derivatives considered were: carboxymethyl–cellulose (NaCMC), P1; cellulose acetate (CA), P2; methyl 2–hydroxyethyl–cellulose (MHEC), P3; and hydroxyethyl–cellulose (HEC), P4. In the permeation module, hydrogen sulfide is captured with a solution of cadmium that forms cadmium sulfide, usable as a luminescent substance. The composite membranes were characterized by SEM, EDAX, FTIR, FTIR 2D maps, thermal analysis (TG and DSC), and from the perspective of hydrogen sulfide air removal performance. To determine the process performances, the variables were as follows: the nature of the cellulosic derivative–polypropylene hollow fiber composite membrane, the concentration of hydrogen sulfide in the polluted air, the flow rate of polluted air, and the pH of the cadmium nitrate solution. The pertraction efficiency was highest for the sodium carboxymethyl–cellulose (NaCMC)–polypropylene hollow fiber membrane, with a hydrogen sulfide concentration in the polluted air of 20 ppm, a polluted air flow rate (QH2S) of 50 L/min, and a pH of 2 and 4. The hydrogen sulfide flux rates, for membrane P1, fall between 0.25 × 10−7 mol·m2·s−1 for the values of QH2S = 150 L/min, CH2S = 20 ppm, and pH = 2 and 0.67 × 10−7 mol·m−2·s−1 for the values of QH2S = 50 L/min, CH2S = 60 ppm, and pH = 2. The paper proposes a simple air purification system containing hydrogen sulfide, using a module with composite cellulosic derivative–polypropylene hollow fiber membranes.
A Literature Review of Fault Detection and Diagnostic Methods in Three-Phase Voltage-Source Inverters
Authors: Ajra Youssef , Hoblos Ghaleb , Al Sheikh Hiba , Moubayed Nazih
Published: September 2024

This review paper offers a comprehensive examination of the various types of faults that occur in inverters and the methods used for their identification. The introductory segment investigates the internal component failures of voltage-source inverters (VSIs), examining their failure rates and the consequent effects on the overall system performance. Subsequently, this paper classifies and clarifies the potential malfunctions in components and sensors, placing particular emphasis on their frequency of occurrence and the severity of their impact. The examination encompasses issues associated with transistors, including open circuits, short circuits, gate firing anomalies, as well as failures in capacitors, diodes, and sensors. Following this, the paper delivers a comparative assessment of fault diagnosis techniques pertinent to each type of component, appraised against specific criteria. The concluding section encapsulates the findings for each fault category, delineates the fault detection and diagnosis (FDD) methodologies, analyzes the outcomes, and provides recommendations for future scholarly investigation.
Three-Layer Artificial Neural Network for Pricing Multi-Asset European Option
Authors: Zhou Zhiqiang , Wu Hongying , Li Yuezhang , Kang Caijuan , Wu You
Published: September 2024

This paper studies an artificial neural network (ANN) for multi-asset European options. Firstly, a simple three-layer ANN-3 is established with undetermined weights and bias. Secondly, the time–space discrete PDE of the multi-asset option is given and the corresponding discrete data are fed into the ANN-3. Then, using least squares error as the objective function, the weights and bias of ANN-3 are trained well. Numerical examples are carried out to confirm the stability, accuracy and efficiency. Experiments show the ANN’s relative error is about 0.8%. This method can be extended into multi-layer ANN-q(q>3) and extended into American options.
FMEA-TSTM-NNGA: A Novel Optimization Framework Integrating Failure Mode and Effect Analysis, the Taguchi Method, a Neural Network, and a Genetic Algorithm for Improving the Resistance in Dynamic Random Access Memory Components
Authors: Lin Chia-Ming , Chen Shang-Liang
Published: September 2024

Dynamic random access memory (DRAM) serves as a critical component in medical equipment. Given the exacting standards demanded by medical equipment products, manufacturers face pressure to improve their product quality. The electrical characteristics of these products are based on the resistance value of the DRAM components. Hence, the purpose of this study is to optimize the resistance value of DRAM components in medical equipment. We proposed a novel FMEA-TSTM-NNGA framework that integrates failure mode and effect analysis (FMEA), the two-stage Taguchi method (TSTM), neural networks (NN), and genetic algorithms (GA) to optimize the manufacturing process. Moreover, the proposed FMEA-TSTM-NNGA framework achieved a substantial reduction in experimental trials, cutting the required number by a factor of 85.3 when compared to the grid search method. Our framework successfully identified optimal manufacturing condition settings for the resistance values of DRAM components: Depo time = 27 s, Depo O2 flow = 151 sccm, ARC-LTO etch time = 43 s, ARC-LTO etch pressure = 97 mTorr, Ox-SiCO etch time = 91 s, Ox-SiCO gas ratio = 22%, and Polish time = 84 s. The results helped the case company improve the resistance value of DRAM components from 191.1 × 10−3 Ohm to 176.84 × 10−3 Ohm, which is closer to the target value of 176.5 × 10−3 Ohm. The proposed FMEA-TSTM-NNGA framework is designed to operate efficiently on resource-constrained, facilitating real-time adjustments to production attributes. This capability enables DRAM manufacturers to swiftly optimize product quality.
An Evolutionary Game-Based Regulatory Path for Algorithmic Price Discrimination in E-Commerce Platforms
Authors: Guo Yan , Lin Jiajun , Zhuang Weiqing
Published: September 2024

With the advent of big data, the swift advancement of diverse algorithmic technologies has enhanced the transaction efficiency of the e-commerce business. Nevertheless, it is crucial to acknowledge that e-commerce platforms might employ algorithmic technology to enforce differential pricing for various consumers with the aim of maximizing profits, thus infringing upon the lawful rights and interests of consumers. This paper focuses on the algorithmic price discrimination commonly observed on e-commerce platforms. To effectively regulate this behavior, the paper utilizes evolutionary game theory (EGT) to analyze the strategies employed by e-commerce platforms, consumers, and market regulators to achieve stability. This research employs a real-life situation and utilizes parametric simulation to visualize and analyze the process and outcomes of the three-party evolutionary game. The results demonstrate the credibility and feasibility of the article’s findings. Based on our research, we have reached the following findings: During the process of evolution, the strategic decisions made by the game participants from the three parties will mutually impact each other, and various elements exert varying degrees of influence on the strategic choices made by the game participants from each party. Collaborative governance can enable consumers and market regulators to regulate the discriminatory pricing behavior of e-commerce platforms effectively. This article offers valuable insights into the governance of violations in the e-commerce sector based on robust data and model research.
Reduction in Optimal Time in Systems with Input Redundancy
Authors: Peng Zhongxing , Zheng Gengzhong , Huang Wei
Published: September 2024

This paper discusses a reduction in the optimal time due to the presence of input redundancy in time-optimal control problems. By introducing a non-idle channel to represent an active input channel, we establish the necessary and sufficient conditions that ensure a strict reduction in the optimal time for affine nonlinear systems. In cases of identical input redundancy, its impact varies according to the type of input constraint, and certain types may not lead to a reduction in the optimal time. Ultimately, in linear time-invariant (LTI) systems, the extent of the optimal time reduction depends on the system’s controllability.
Comprehensive Microbiological and Metagenomic Analysis of the Guillain–Barré Syndrome Outbreak in Lima, 2019
Authors: Rojas Jesús D. , Ramos Mariana , Cruz Cristopher , Long Kyle A. , Voegtly Logan J. , Meza Rina , Espinoza Nereyda , Ttito Ana Ramos , Cáceres Hugo Umeres , Cuentas Alejandro Llanos , Meza Yocelinda , Troncos Gilda , Poly Frédéric M. , Paskey Adrian C. , Lueder Matthew R. , Rice Gregory K. , Cer Regina Z. , Bishop-Lilly Kimberly A. , Silva María , Grogl Max
Published: September 2024

In 2018/2019, two large Guillain–Barré Syndrome (GBS) outbreaks took place in Peru. Here, we report a comprehensive analysis of biological samples from GBS patients from the 2019 outbreak. We applied metagenomic, microbiologic, and serological analyses to different biological samples collected from GBS patients. Further phenotypic and genomic characterization was conducted on Campylobacter jejuni isolates from GBS samples. Microbiologic and metagenomic analyses revealed several patients with multiple co-infections, yet no common infectious agents were found other than C. jejuni. Four C. jejuni isolates were isolated from rectal swabs. Twenty-one patients had detectable IgG serum antibodies related to C. jejuni, of whom seven had IgM antibodies. Genomic analyses showed that these four strains were clonal (ST2993) and contained the class A lipooligosaccharide biosynthesis locus. These results further support the idea that that C. jejuni is the etiological agent that triggered the GBS outbreak in Peru in 2019 and that the strains are not restricted to Peru, hence could be regarded as a broad public health concern. Furthermore, though we cannot delineate the role played by co-infections in GBS development, results obtained herein highlight metagenomic analysis as a potential new tool for depicting a yet unknown area of research in GBS.
A Facile and Green Approach for the Preparation of Silver Nanoparticles on Graphene Oxide with Favorable Antibacterial Activity
Authors: Tene Talia , Bellucci Stefano , Pachacama Joseth , Cuenca-Lozano María F. , Tubon-Usca Gabriela , Guevara Marco , La Pietra Matteo , Cruz Salazar Yolenny , Scarcello Andrea , Arias Polanco Melvin , Gahramanli Lala Rasim , Vacacela Gomez Cristian , Caputi Lorenzo S.
Published: September 2024

Herein, we introduce a simple precipitation method for preparing graphene oxide–silver nanoparticle (GO/AgNP) composites, utilizing Calendula officinalis (C. officinalis) seed extract as both a reducing and stabilizing agent. Our research combines the sustainable preparation of graphene oxide (GO) with the green synthesis of silver nanoparticles (AgNPs), aiming to explore the potential of the obtained composite as a novel antibacterial material. To establish a benchmark, the synthesis was also performed using sodium citrate, a conventional reducing agent. The resultant GO/AgNP composites were characterized through several analytical techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), energy dispersive X-ray spectroscopy (EDS), Raman spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, and ultraviolet–visible (UV-vis) spectroscopy, confirming the successful functionalization of GO with AgNPs. The antibacterial effectiveness of the composites was systematically assessed against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), with nanoparticle concentrations spanning from 0 to 250 µg/mL, utilizing mostly disk diffusion and colony-forming unit (CFU) count assays. The AgNPs were characterized by a size range of 15–50 nm. Notably, the GO/AgNP composite prepared using C. officinalis seed extract demonstrated superior antibacterial activity at all tested concentrations, outperforming both pure GO and the GO/AgNP composite prepared with sodium citrate. The most pronounced antibacterial effect was observed at a concentration of 32.0 µg/mL. Therefore, this innovative synthesis approach may offer a valuable contribution to the development of new therapeutic agents to combat bacterial infections, suggesting further exploration into antibacterial coatings or potential drug development.
Producing Freestanding Single-Crystal BaTiO3 Films through Full-Solution Deposition
Authors: Xi Guoqiang , Li Hangren , Lu Dongfei , Liu Xudong , Liu Xiuqiao , Tu Jie , Yang Qianqian , Tian Jianjun , Zhang Linxing
Published: September 2024

Strontium aluminate, with suitable lattice parameters and environmentally friendly water solubility, has been strongly sought for use as a sacrificial layer in the preparation of freestanding perovskite oxide thin films in recent years. However, due to this material’s inherent water solubility, the methods used for the preparation of epitaxial films have mainly been limited to high-vacuum techniques, which greatly limits these films’ development. In this study, we prepared freestanding single-crystal perovskite oxide thin films on strontium aluminate using a simple, easy-to-develop, and low-cost chemical full-solution deposition technique. We demonstrate that a reasonable choice of solvent molecules can effectively reduce the damage to the strontium aluminate layer, allowing successful epitaxy of perovskite oxide thin films, such as 2-methoxyethanol and acetic acid. Molecular dynamics simulations further demonstrated that this is because of their stronger adsorption capacity on the strontium aluminate surface, which enables them to form an effective protective layer to inhibit the hydration reaction of strontium aluminate. Moreover, the freestanding film can still maintain stable ferroelectricity after release from the substrate, which provides an idea for the development of single-crystal perovskite oxide films and creates an opportunity for their development in the field of flexible electronic devices.