bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiological Functional Assessment of National Olympic Team of Kazakhstan
Authors: Yerezhepov Dauren , Gabdulkayum Aidana , Bilyalova Galiya , Amangeldikyzy Saya , Kozhamkulov Ulan A. , Rakhimova Saule E. , Kairov Ulykbek Y. , Akilzhanova Ainur
Published: December 2023

Athletes carry an increased risk of cardiovascular (CV) conditions. Due to the relatively high loads and intensity of the training process, athletes’ CV systems undergo various adaptations, which can combine in the future and provoke unexpected outcomes. Most CV screening protocols have several successive steps. The aim of our study was to perform a cardiological functional assessment of the National Olympic Team of Kazakhstan via several noninvasive protocols to close the gaps between the approaches and collect solid data for the prevention of sudden cardiac death (SCD) incidence among Kazakhstani athletes. Methods: The methods used in this study were 12-lead resting electrocardiography (ECG), echocardiography, cardiointervalography, cardiopulmonary exercise testing (CPET), and HyperQ stress testing. Results: One case was detected via 12-lead resting ECG. Another case of the slowdown of the heart rate (HR) recovery was detected via cardiointervalography with no clinical signs and normal ECG. The HyperQ stress testing of the women’s basketball team detected a positive result in four leads in one athlete. Conclusion: Our results demonstrate that the CV systems of athletes require the implementation of several diagnostic methods in rest and stress conditions for more precise evaluation, with each of the methods fulfilling the whole picture for the prevention of such tragic events as sudden cardiac death and sudden cardiac arrest.
The Analysis of Multiple Outcomes between General and Regional Anesthesia in Hip Fracture Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Viderman Dmitriy , Aubakirova Mina , Nabidollayeva Fatima , Abdildin Yerkin G.
Published: December 2023

Surgical interventions in hip fracture have been associated with multiple adverse events, including perioperative hypotension and mortality, making the choice of the anesthetic method for this procedure crucial. There is still no consensus on whether regional (RA) or general (GA) anesthesia should be used to maintain hemodynamic stability and more favorable outcomes. Therefore, this meta-analysis examines the differences between RA and GA groups in the incidence of mortality, intraoperative hypotension, and other intra- and postoperative complications. The comparison is essential given the rising global prevalence of hip fractures and the need to optimize anesthesia strategies for improved patient outcomes, particularly in an aging population. We followed PRISMA guidelines (PROSPERO #CRD42022320413). We conducted the search for studies published in English before March 2022 in PubMed, Google Scholar, and the Cochrane Library. We included RCTs that compared general and regional anesthesia in adult patients having hip fracture surgical interventions. The primary outcome was perioperative mortality. The secondary outcomes were peri- or postoperative complications and duration of hospital stay. We conducted a meta-analysis in RevMan (version 5.4). We examined the quality of the methodology with the Cochrane risk of bias 2 tool, while the quality of evidence was determined with GRADE. Fifteen studies with 4110 patients were included. Our findings revealed no significant difference between general and regional anesthesia in risk of perioperative mortality (RR = 1.42 [0.96, 2.10], p-value = 0.08), intraoperative complications, or duration of hospital length of stay. Our results suggest that regional anesthesia and general anesthesia have comparable safety and can be used as alternatives based on specific patient requirements.
Lung Ultrasound Elastography by SWE2D and “Fibrosis-like” Computed Tomography Signs after COVID-19 Pneumonia: A Follow-Up Study
Authors: Paredes-Manjarrez Carlos , Avelar-Garnica Francisco J. , Balderas-Chairéz Andres Tlacaelel , Arellano-Sotelo Jorge , Córdova-Ramírez Ricardo , Espinosa-Poblano Eliseo , González-Ruíz Alejandro , Anda-Garay Juan Carlos , Miguel-Puga José Adan , Jáuregui-Renaud Kathrine
Published: December 2023

The aim of this study was to assess the shear wave velocity by LUS elastography (SWE2D) for the evaluation of superficial lung stiffness after COVID-19 pneumonia, according to “fibrosis-like” signs found by Computed Tomography (CT), considering the respiratory function. Seventy-nine adults participated in the study 42 to 353 days from symptom onset. Paired evaluations (SWE2D and CT) were performed along with the assessment of arterial blood gases and spirometry, three times with 100 days in between. During the follow-up and within each evaluation, the SWE2D velocity changed over time (MANOVA, p < 0.05) according to the extent of “fibrosis-like” CT signs by lung lobe (ANOVA, p < 0.05). The variability of the SWE2D velocity was consistently related to the first-second forced expiratory volume and the forced vital capacity (MANCOVA, p < 0.05), which changed over time with no change in blood gases. Covariance was also observed with age and patients’ body mass index, the time from symptom onset until hospital admission, and the history of diabetes in those who required intensive care during the acute phase (MANCOVA, p < 0.05). After COVID-19 pneumonia, SWE2D velocity can be related to the extent and regression of “fibrotic-like” involvement of the lung lobes, and it could be a complementary tool in the follow-up after COVID-19 pneumonia.
Primary Anaplastic-Lymphoma-Kinase-Positive Large-Cell Lymphoma of the Central Nervous System: Comprehensive Review of the Literature
Authors: Colamaria Antonio , Leone Augusto , Carbone Francesco , Dallos Laguado Yasser Andres , Fochi Nicola Pio , Sacco Matteo , Fesce Cinzia , Sanguedolce Francesca , Giordano Guido , Iaconetta Giorgio , Spetzger Uwe , Coppola Luigi , De Santis Elena , Coppola Giulia , De Notaris Matteo
Published: December 2023

Background: Primary anaplastic-lymphoma-kinase (ALK)-positive large-cell lymphoma of the central nervous system (PCNS ALK-positive ALCL) is a rare entity, with a limited consensus reached regarding its management. While this pathology often presents as solitary lesions, the occurrence of multiple tumors within the brain is not uncommon. The lack of distinctive radiological features poses a diagnostic challenge, leading to delays in initiating targeted therapy. Methods: We conducted a comprehensive literature search, identifying seventeen publications for qualitative analysis. Results: The management options and reported patient outcomes in the literature varied significantly, emphasizing the need for a patient-specific approach. The emergence of ALK-specific inhibitors represents a new frontier in this field, demonstrating promising results. Conclusion: PCNS ALK-positive ALCL necessitates a comprehensive understanding and optimized management strategies. A tailored therapeutic approach, integrating surgical intervention with radiotherapy and chemotherapy, appears pivotal in addressing this pathology. The implementation of a therapeutic protocol is anticipated for further advancement in this field.
Remdesivir-Induced Bradycardia and Mortality in SARS-CoV-2 Infection, Potential Risk Factors Assessment: A Systematic Review and Meta-Analysis
Authors: Ai Ming-Ying , Chang Wei-Lun , Yang Chia-Jui
Published: December 2023

Background: The efficacy of remdesivir in reducing disease severity among COVID-19-infected patients has been established, but concerns have emerged regarding the potential side effects of bradycardia. The aim of this study was to investigate the association between remdesivir-induced bradycardia and mortality, while also identifying the related risk factors. Materials and methods: The PubMed/Medline, Cochrane Central and ClinicalTrials.gov databases were searched. Randomized controlled trials and prospective or retrospective cohort studies were included (through 14 July 2023). The random-effects model was implemented using Comprehensive Meta-Analysis software version 3.0 to examine the outcomes. Results: A total of 12 prospective or retrospective studies involving 7674 patients were analyzed. The primary outcomes revealed a significant association between remdesivir administration and bradycardia development (Odds ratio = 2.556, 95% CI = 2.049–3.188, p < 0.001). However, no statistically significant increase in the mortality rate was observed among patients with bradycardia during remdesivir treatment (Odds ratio = 0.872, 95% CI = 0.483–1.576, p = 0.651). The secondary outcome demonstrated a significant association between chronic kidney disease (CKD) and remdesivir-induced bradycardia (OR: 1.251, 95% CI: 1.003–1.561, p = 0.047). Moreover, patients with obesity (OR = 1.347, 95% CI = 1.098–1.652, p = 0.004) were more likely to experience remdesivir-induced bradycardia. Conclusions: Although a higher risk of bradycardia occurred during remdesivir treatment, the occurrence of remdesivir-induced bradycardia did not lead to higher mortality. Our study also identified patients with obesity and CKD as high-risk subgroups for experiencing bradycardia during remdesivir treatment.
Association of Physical Activity and Exercise with Physical Performance and Muscle Mass in Older Adults: Results from the Longevity Check-Up (Lookup) 7+ Project
Authors: Coelho-Júnior Hélio José , Calvani Riccardo , Picca Anna , Tosato Matteo , Landi Francesco , Marzetti Emanuele
Published: December 2023

Regular engagement in physical activity (PA) or physical exercise (PE) is effective at improving physical performance and body composition in older adults. Less is known about the benefits that may be obtained through combining PA with PE and whether the effects of activity habits differ between men and women. This study cross-sectionally investigated the association of PA and/or PE with physical performance and anthropometric measures in a large and relatively unselected sample of older adults enrolled in the Longevity Check-up (Lookup) 7+ project. Participants were individuals 65 years and older living in the community who were recruited in unconventional settings across Italy. Adherence to PA or PE was operationalized as involvement in light walking or various types of exercise, respectively, at least twice weekly for a minimum of 30 min per session throughout the last 12 months. Physical performance measures included handgrip strength and five-time sit-to-stand (5STS) tests. Lower-limb muscle power and appendicular skeletal muscle mass (ASM) were estimated through validated equations. We analyzed data of 4119 participants, of whom 2222 (53.4%) were women. The mean age was 72.8 ± 5.8 years in men and 72.1 ± 5.4 years in women. Regular engagement in PA + PE was reported by 139 (7.3%) men and 100 (4.5%) women. Results indicated that regular walking activity and/or PE were significantly associated with better physical performance and greater ASM with sex-specific patterns. Associations were also influenced by the type of activity, physical performance assessment tool, and anthropometric parameters. Men engaged in PA + PE performed better on the 5STS test and had greater handgrip strength, ASM, and relative and specific muscle power than those practicing either PA or PE. In women, the combination of PA and PE was associated with greater handgrip strength. The findings of this study indicate that older adults regularly practicing PA + PE had better physical performance than those who only engaged in either modality. In men, the combination of PA and PE was also associated with greater ASM.
Hydrophilic–Hydrophobic Properties of the Surface of Modified Carbonate Fillers for Asphalt
Authors: Lebedev Mikhail , Yadykina Valentina , Akimov Andrey , Kozhukhova Marina , Kuznetsova Ekaterina
Published: December 2023

The physicochemical modification of the filler allows changing the hydrophilic–hydrophobic properties and effectively influencing the processes occurring at the filler–binder interface, on which the physicomechanical characteristics of composites largely depend. The paper presents studies related to the modification of limestone-based filler effect on the degree of its hydrophobicity and wetting with liquids of different polarity, establishing the relationship between the characteristics of hydrophobized mineral powders and the adsorption capacity in relation to water. Using mechanochemical processing with hydrophobic components GF-1 and GF-2, it was possible to obtain fillers with a sufficiently high content of hydrophobic particles (58.2% and 85.9%, respectively). It was found that the results of the contact angle (123.6° and 114.5°, respectively) and the degree of hydrophobicity do not quite correlate with each other. It was noticed that the contact angle on the powder modified with GF-1 decreases with time. Studies of the powders’ thermal effects wetting of different polarity liquids via microcalorimetry allows us to establish that with an increase in the filler hydrophobicity degree, the integral heat of immersion decreases due to a significant decrease in the probability of chemical interactions between water and powder due to the adsorption of applied surfactants molecules on the limestone active centers. The revealed endothermic effects indicate the occurrence of physical interactions due to non-polar dispersion forces. Differences in the nature of heat release and heat absorption in modified fillers indicate significant differences in the composition and mechanism of action of the used surfactants, which affected the efficiency of hydrophobization. At the same time, a linear dependence of the moisture absorption and moisture indicators, determined by independent experiments, on the degree of hydrophobicity was established.
Behavior of Calcium Compounds under Hydrothermal Conditions during Alkaline Leaching of Aluminosilicates with the Synthesis of Fillers for Composites
Authors: Abdulvaliyev Rinat , Akhmadiyeva Nazym , Gladyshev Sergey , Samenova Nazira , Kolesnikova Olga , Mankesheva Olimpiada
Published: December 2023

Calcium oxide plays an important role in alumina production by binding SiO2 from aluminosilicate raw materials (bauxite, nepheline, kaolinite, etc.) in aluminum-free compounds. The efficiency of the hydrochemical technology depends on the activities of calcium oxide or its compounds introduced into the alkaline aluminosilicate slurry. In this paper, we considered the effects of different calcium compounds (calcium carbonate CaCO3, gypsum CaSO4·H2O, calcium oxide CaO and calcium hydroxide Ca(OH)2), introduced during the hydrothermal stripping of aluminosilicates with alkaline solutions, on the degree of aluminum oxide extraction, with the subsequent production of fillers for composites. Ca(OH)2 was obtained by the CaO quenching method. Extraction of Al2O3 in an alkaline solution was only possible with Ca(OH)2, and the degree of extraction depended on the conditions used for CaO quenching. The effects of temperature and of the duration of CaO quenching on particle size were investigated. In potassium solution, the best results for Al2O3 extraction were obtained using CaSO4·H2O gypsum. The obtained solutions were processed using the crystallization method.
Real-Time Underwater Acoustic Homing Weapon Target Recognition Based on a Stacking Technique of Ensemble Learning
Authors: Deng Jianjing , Yang Xiangfeng , Liu Liwen , Shi Lei , Li Yongsheng , Yang Yunchuan
Published: December 2023

Underwater acoustic homing weapons (UAHWs) are formidable underwater weapons with the capability to detect, identify, and rapidly engage targets. Swift and precise target identification is crucial for the successful engagement of targets via UAHWs. This study presents a real-time target recognition method for UAHWs based on stacking ensemble technology. UAHWs emit active broadband detection signals that manifest distinct reflection characteristics on the target. Consequently, we have extracted energy and spatial distribution features from the target’s broadband correlation detection output. To address the problem of imbalanced original sea trial data, we employed the SMOTE algorithm to generate a relatively balanced dataset. Then, we established a stacking ensemble model and performed training and testing on both the original dataset and relatively balanced dataset separately. In conclusion, we deployed the stacking ensemble model on an embedded system. The proposed method was validated using real underwater acoustic homing weapon sea trial data. The experiment utilized 5-fold cross-validation. The results indicate that the method presented in this study achieved an average accuracy of 93.3%, surpassing that of individual classifiers. The model’s single-cycle inference time was 15 ms, meeting real-time requirements.
Functional Analysis of a Salicylate Hydroxylase in Sclerotinia sclerotiorum
Authors: He Shengfei , Huang Kun , Li Baoge , Lu Guodong , Wang Airong
Published: December 2023

Salicylic acid plays a crucial role during plant defense to Sclerotinia sclerotiorum. Some bacteria and a few fungi can produce salicylate hydroxylase to degrade SA to suppress plant defense and increase their virulence. But there has been no single salicylate hydroxylase in Sclerotinia sclerotiorum identified until now. In this study, we found that SS1G_02963 (SsShy1), among several predicted salicylate hydroxylases in S. sclerotiorum, was induced approximately 17.6-fold during infection, suggesting its potential role in virulence. SsShy1 could catalyze the conversion of SA to catechol when heterologous expression in E. coli. Moreover, overexpression of SsShy1 in Arabidopsis thaliana decreased the SA concentration and the resistance to S. sclerotiorum, confirming that SsShy1 is a salicylate hydroxylase. Deletion mutants of SsShy1 (∆Ssshy1) showed slower growth, less sclerotia production, more sensitivity to exogenous SA, and lower virulence to Brassica napus. The complemented strain with a functional SsShy1 gene recovered the wild-type phenotype. These results indicate that SsShy1 plays an important role in growth and sclerotia production of S. sclerotiorum, as well as the ability to metabolize SA affects the virulence of S. sclerotiorum.
An Efficient CRISPR/Cas9 Genome Editing System for a Ganoderma lucidum Cultivated Strain by Ribonucleoprotein Method
Authors: Tan Yi , Yu Xianglin , Zhang Zhigang , Tian Jialin , Feng Na , Tang Chuanhong , Zou Gen , Zhang Jingsong
Published: December 2023

The CRISPR/Cas9 system has become a popular approach to genome editing. Compared with the plasmid-dependent CRISPR system, the ribonucleoprotein (RNP) complex formed by the in vitro assembly of Cas9 and single-guide RNA (sgRNA) has many advantages. However, only a few examples have been reported and the editing efficiency has been relatively low. In this study, we developed and optimized an RNP-mediated CRISPR/Cas9 genome editing system for the monokaryotic strain L1 from the Ganoderma lucidum cultivar ‘Hunong No. 1’. On selective media containing 5-fluoroorotic acid (5-FOA), the targeting efficiency of the genomic editing reached 100%. The editing efficiency of the orotidine 5′-monophosphate decarboxylase gene (ura3) was greater than 35 mutants/107 protoplasts, surpassing the previously reported G. lucidum CRISPR systems. Through insertion or substitution, 35 mutants introduced new sequences of 10–569 bp near the cleavage site of ura3 in the L1 genome, and the introduced sequences of 22 mutants (62.9%) were derived from the L1 genome itself. Among the 90 mutants, 85 mutants (94.4%) repaired DNA double-strand breaks (DSBs) through non-homologous end joining (NHEJ), and five mutants (5.6%) through microhomology-mediated end joining (MMEJ). This study revealed the repair characteristics of DSBs induced by RNA-programmed nuclease Cas9. Moreover, the G. lucidum genes cyp512a3 and cyp5359n1 have been edited using this system. This study is of significant importance for the targeted breeding and synthetic metabolic regulation of G. lucidum.
Variability in Provider Assessment of Sepsis and Potential of Host Response Technology to Address this Dilemma—Results of an Online Delphi Study
Authors: Kraus Chadd K. , O’Neal Hollis R. , Ledeboer Nathan A. , Rice Todd W. , Self Wesley H. , Rothman Richard E.
Published: December 2023

Potentially septic patients have a huge clinical and economic impact on hospitals and often present to the emergency department (ED) with undifferentiated symptoms. The triage of these patients is complex and has historically relied heavily upon provider judgment. This study aims to evaluate the consistency of provider judgment and the potential of a new host response sepsis test to aid in the triage process. A modified Delphi study involving 26 participants from multiple specialties was conducted to evaluate provider agreement about sepsis risk and to test proposed actions based on the results of a sepsis test. The participants considered case vignettes of potentially septic patients designed to represent diagnostic dilemmas. Provider assessment of sepsis risk in these cases ranged from 10% to 90% and agreement was poor. Agreement about clinical actions to take in response to testing improved when participants considered their own hypothetical borderline cases. New host response testing for sepsis may have the potential to improve sepsis diagnosis and care and should be applied in a protocolized fashion to ensure consistency of results.
Association between COVID-19 Infection or Vaccination Outcomes and Methylenetetrahydrofolate Reductase Gene Polymorphism: A Systematic Review of the Literature
Authors: Jukic Ivana , Heffernan Aisling , Schelling Alisa Franceska , Kokic Males Visnja , Savicevic Nora Josipa , Kovacic Vedran
Published: December 2023

Background: Thrombosis is a detrimental sequala of COVID-19 infection; thus, prophylactic anti-coagulant therapy has been deemed mandatory in treatment unless serious contraindications are present. Susceptibility to thromboembolic events in COVID-19, or following COVID-19 vaccination, is likely attributable to an interplay of factors, including a patient’s baseline clinical status and comorbidities, alongside genetic risk factors. In Europe, 8–20% of the population are homozygous for the MTHFR (methylene tetrahydrofolate reductase) variant, which compromises folate metabolism and elevates homocysteine levels. While heightened homocysteine levels are considered a risk factor for thromboembolic events, the precise clinical significance remains a contentious issue. However, recent research suggests elevated homocysteine levels may predict the course and severity of COVID-19 infection. Given the lack of reliable biomarkers predictive of COVID-19 thrombotic risk existing in practice, and the accessibility of MTHFR screening, we established two main outcomes for this study: (1) to determine the association between hereditary MTHFR mutations and COVID-19 severity and thromboembolic events and (2) to determine the link between MTHFR variants and adverse thrombotic events following COVID-19 vaccination. Methods: The review was conducted in accordance with PRISMA guidelines. Medline, Scopus, and Web of Science databases were searched from pandemic inception (11 March 2020) to 30 October 2023. Eligibility criteria were applied, and data extraction performed. Results: From 63 citations identified, a total of 14 articles met the full inclusion criteria (8 of which were cross-sectional or observational studies, and 6 were case studies or reports). Among the eight observational and cross-sectional studies evaluating the relationship between MTHFR variants (C667T; A1298C) and thromboembolic events in COVID-19 infection, four studies established a connection (n = 2200), while the remaining four studies failed to demonstrate any significant association (n = 38). Conclusions: This systematic review demonstrated a possible association between the MTHFR gene variants and COVID-19 severity, thromboembolic events, and adverse events following vaccination. However, the paucity of robust data precluded any firm conclusions being drawn. Further prospective trials are required to determine the connection between the MTHFR gene variant and COVID-19 infection and vaccination outcomes.
Information Theory and the Pricing of Contingent Claims: An Alternative Derivation of the Black–Scholes–Merton Formula
Authors: Davis Thomas P.
Published: December 2023

This paper seeks to determine the best subjective probability to use to carry out expectation values of uncertain future cash flows with the smallest number of assumptions. This results in the unique distribution that guarantees no more information is present other than the stated assumptions. The result is a novel derivation of the well-known Black–Scholes equation without the need to introduce high-level mathematical machinery. This formalism fits nicely into introductory courses of finance, where the value of any financial instrument is given by the present value of uncertain future cash flows.
Respiratory Infection by Cyathostoma (Hovorkonema) americana in a Population of Burrowing Owls (Athene cunicularia)—A Potential Case of Zoo–Wildlife Cross-Transmission
Authors: Marques Gonçalo N. , Cruz João T. , Pinto Matilde , Leal Miriam , Flanagan Carla , Urbani Nuno , de Carvalho Luís Madeira
Published: December 2023

A population of burrowing owls (Athene cunicularia) under professional care at Zoomarine Portugal presented with sudden respiratory clinical signs. Clinical management included a thorough diagnosis plan, including in-house fecal analysis that revealed the presence of ovoid unioperculate eggs. In the postmortem examination of one hyperacute dyspneic specimen, adult nematode parasites were collected and identified based on their morphology as Cyathostoma (Hovorkonema) americana. Even after a broad-spectrum deworming protocol as part of the treatment and metaphylaxis approach, the incidence of parasitic reinfection was high. The complete clinical resolution was only accomplished after the identification and management of the possible focus of infection, a wild population of cattle egrets (Bubulcus ibis) that frequently congregated above the owls’ habitat. To the authors’ best knowledge, this is the first report of infection by Cyathostoma (Hovorkonema) americana in burrowing owls. Although nematodes of the family Syngamidae are not commonly included in the differential diagnosis of infectious respiratory agents of birds of the order Strigiformes, this report highlights the possibility of opportunistic parasitism in a zoological context, especially where there is a continued proximity to free-ranging avifauna.
Real-World Data on Second-Line Therapy with Ramucirumab for Metastatic Gastric Cancer: A Two-Center Study on Romanian Population
Authors: Galos Diana , Balacescu Loredana , Vidra Radu , Sur Daniel
Published: December 2023

(1) Background: Following the results of RAINBOW and REGARD trials, ramucirumab was approved as the standard second-line treatment for patients with advanced or metastatic gastric or gastroesophageal junction (GEJ) cancer, alone or in combination with paclitaxel. The present study aimed to evaluate the efficacy and safety of ramucirumab in the Romanian population during every-day clinical practice. (2) Methods: A two-center, retrospective, observational study evaluated patients with metastatic gastric and GEJ cancer treated with ramucirumab monotherapy or associated with paclitaxel. The patients were treated between 2018 and 2022 in two Romanian centers as follows: 18 patients underwent treatment with ramucirumab monotherapy, while 51 received the combined treatment regimen. Study endpoints included median progression-free survival (PFS), median overall survival (OS), and the evaluation of treatment-induced adverse events (AEs). (3) Results: In the study cohort (n = 69), the most frequent treatment-induced AE in the ramucirumab plus paclitaxel arm was hematological toxicity; the most common AE for patients treated with ramucirumab monotherapy was fatigue and headache. Overall, the median PFS was 4.7 months (95% CI: 3.4–5.9 months) and median OS was 18.23 months (95% CI: 15.6–20.7 months). PFS was correlated with the number of treatment cycle administrations, Eastern Cooperative Oncology Group performance status at treatment initiation, and metastatic site (visceral vs. peritoneal). OS was correlated with the number of treatment cycles administered and human epidermal growth factor receptor-2 status. (4) Conclusions: The results support the previously described toxicity profile for ramucirumab monotherapy or associated with paclitaxel and demonstrated a relatively superior median PFS.
Microbiome Changes in Layer Pullets Reared in Floor Pens along the Growth Period
Authors: Kim Hee-Jin , Kim Hyun-Soo , Yun Yeon-Seo , Shin Hyekyoung , Lee Woo-Do , Son Jiseon , Hong Eui-Chul , Jeon Ik-Soo , Kang Hwan-Ku
Published: December 2023

The gastrointestinal tract microbiome is essential for regulating nutrient absorption, gut immune function, and host growth and development. In the present study, we characterized the development of ileum and cecum microbiota in pullets throughout the rearing period, encompassing a period from the day of hatching to 18 weeks of age. The growth performance and intestinal microbiome (ileum and cecum) of pullets were analyzed at 1, 5, 11, and 18 weeks of age. The richness of the ileum and cecum bacterial communities (alpha diversity) was higher in pullets at 18 weeks of age than in those at 1 and 5 weeks of age. Microbiota from weeks 1, 5, 11, and 18 were distinctly grouped in a NMDS plot, representing beta diversity within the ileum. However, the results for cecum microbiota did not reveal evident separation among the different age groups in the weighted UniFrac. In conclusion, our findings demonstrate variations and diversification in ileum and cecum microbiota across different rearing stages in pullets. These insights have the potential to inform the development of nutritional strategies that promote gut health and contribute to the improved development of pullets.
Truck–Shovel vs. In-Pit Crushing and Conveying Systems in Open Pit Mines: A Technical Evaluation for Selecting the Most Effective Transportation System by System Dynamics Modeling
Authors: Abbaspour Hossein , Drebenstedt Carsten
Published: December 2023

Backgrounds: The transportation system within any mining project, which is responsible for delivering extracted ore to the crushing units or wastes to the wasting dumps as the destinations, poses a significant challenge in mining processes. On one hand, there are various transportation systems, notably the Truck–Shovel, the traditional method, and relatively newer and less common In-Pit Crushing and Conveying (IPCC) systems. On the other hand, choosing the most suitable system for a specific mining project depends on various factors, with technical aspects being one of the most critical. While there is extensive research on the Truck–Shovel system from a technical perspective, there is relatively limited research on IPCC systems. Methods: This research aims to carry out a comparative analysis of different transportation systems, encompassing Truck–Shovel, Fixed In-Pit Crushing and Conveying (FIPCC), Semi-Fixed In-Pit Crushing and Conveying (SFIPCC), Semi-Mobile In-Pit Crushing and Conveying (SMIPCC), and Fully Mobile In-Pit Crushing and Conveying (FMIPCC) systems. To achieve this goal, a technical index is introduced, which is based on three elements: the availability and the utilization of the system, as well as the consumption of power. This index will be developed as a system dynamics model, enabling the observation of each system’s performance throughout the operational lifespan of the mine. Results: Ultimately, based on the proposed method, the most effective transportation system based on the defined technical index can be identified at any time of the project. In this research, the Truck–Shovel system generally selected as the most preferred transportation system, except for two different periods. Conclusions: This study could successfully perform the selection among different transportation systems. Nevertheless, it was modeled and performed in a deterministic environment, but still the stochastic nature of the processes can be another topic of research.
PID-Based Longitudinal Control of Platooning Trucks
Authors: Shaju Aashish , Southward Steve , Ahmadian Mehdi
Published: December 2023

This article focuses on the development and assessment of a PID-based computationally cost-efficient longitudinal control algorithm for platooning trucks. The study employs a linear controller with a nested architecture, wherein the inner loop regulates relative velocities while the outer loop governs inter-vehicle distances within platoon vehicles. The design of the proposed PID controller entails a comprehensive focus on system identification, particularly emphasizing actuation dynamics. The simulation framework used in this study has been established through the integration of TruckSim® and Simulink®, resulting in a co-simulation environment. Simulink® serves as the platform for control action implementation, while TruckSim® simulates the vehicle’s dynamic behavior, thereby closely replicating real world conditions. The significant effort in fine-tuning the PID controller is described in detail, including the system identification of the linearized longitudinal dynamic model of the truck. The implementation is followed by an extensive series of simulation tests, systematically evaluating the controller’s performance, stability, and robustness. The results verify the effectiveness of the proposed controller in various leading truck operational scenarios. Furthermore, the controller’s robustness to large fluctuations in road grade and payload weight, which is commonly experienced in commercial vehicles, is evaluated. The simulation results indicate the controller’s ability to compensate for changes in both road grade and payload. Additionally, an initial assessment of the controller’s efficiency is conducted by comparing the commanded control efforts (total torque on wheels) along with the total fuel consumed. This initial analysis suggests that the controller exhibits minimal aggressive tendencies.
Global Dynamics in an Alcoholism Epidemic Model with Saturation Incidence Rate and Two Distributed Delays
Authors: Wang Zejun , Liu Haicheng , Li Mingyang , Yang Mei
Published: December 2023

In this study, considering the delays for a susceptible individual becoming an alcoholic and the relapse of a recovered individual back into being an alcoholic, we formulate an epidemic model for alcoholism with distributed delays and relapse. The basic reproduction number R0 is calculated, and the threshold property of R0 is established. By analyzing the characteristic equation, we demonstrate the local asymptotic stability of the different equilibria under various conditions: when R0<1, the alcoholism-free equilibrium is locally asymptotically stable; when R0>1, the alcoholism equilibrium exists and is locally asymptotically stable. Furthermore, we demonstrate the global asymptotic stability at each equilibrium using a suitable Lyapunov function. Specifically, when R0<1, the alcoholism-free equilibrium is globally asymptotically stable; when R0>1, the alcoholism equilibrium is globally asymptotically stable. The sensitivity analysis of R0 shows that reducing exposure is more effective than treatment in controlling alcoholism. Interestingly, we found that extending the latency delay h1 and relapse delay h2 also effectively contribute to the control of the spread of alcoholism. Numerical simulations are also provided to support our theoretical results.
Green Vessel Scheduling with Weather Impact and Emission Control Area Consideration
Authors: Wen Xin , Chen Qiong , Yin Yu-Qi , Lau Yui-yip
Published: December 2023

Emissions of maritime transport have been a critical research topic with the substantial growth in the global shipping industry, encompassing both the expansion of the world fleet and the increased distances it has been covering recently. The International Maritime Organization (IMO) has enforced some regulations to mitigate ship Greenhouse Gas (GHG) emissions, which affect vessels’ operational practice, and further affect service reliability. In this paper, some compliance methods (two-speed strategy, fuel switching, and LNG) against Emission Control Areas (ECAs) at the operational level are examined regarding if and how they impact the liner shipping schedule and service reliability; meanwhile, uncertain weather conditions and port times, as the main uncertain factors, are also involved. Then, a bi-objective fuzzy programming model is formulated and solved by the augmented ε-constraint approach, which generates a set of Pareto solutions by balancing the economic and environmental sustainability. Some findings can be concluded through the experimental results, including that, firstly, to meet uncertain weather conditions at sea requires strong robustness; secondly, ECA regulations can negatively affect the liner shipping service level; moreover, slow steaming is an immediate and effective measure to reduce GHG emissions; and, furthermore, ship routing choice could have a significant influence on ship emissions and service reliability.
Prostatic Artery Origin Variability: Five Steps to Improve Identification during Percutaneous Embolization
Authors: Șerbănoiu Alexandru , Nechifor Rareș , Marinescu Andreea Nicoleta , Iana Gheorghe , Bratu Ana Magdalena , Sălcianu Iulia Alecsandra , Ion Radu Tudor , Filipoiu Florin Mihail
Published: December 2023

Background and Objectives: The purpose of the current paper is to present our study on the variability in the prostatic artery origin, discuss the less frequent origins, and present the challenges of the prostatic artery embolization (PAE) procedure, thus aiding young interventional radiologists. Materials and Methods: We studied the origins of the prostatic artery on digital subtraction angiography (DSA) examinations from PAE procedures on 35 male pelvises (70 hemi-pelvises). Results: Our study has demonstrated that the most frequent origin of the prostatic artery (PA) is the internal pudendal artery (IPA), 37.1%, followed by the anterior gluteal trunk, 27.1%, and the superior vesical artery (SVA), 21.4%. Less frequent origins are the obturator artery (OBT), 11.4%, and the inferior gluteal artery (IGA), 2.8%. Conclusions: Compared to other studies, we notice some differences in the statistical results, but the most frequent origins remain the same. What is more important for young interventional radiologists is to be aware of all the possible origins of the PA in order to be able to offer a proper treatment to their patients. The important aspect that will ensure the success of the procedure without post-procedural complications is represented by the successful embolization of the targeted prostatic parenchyma.
Two Cases of Lymph Node Metastasis Found in Differentiated, Small-Sized Gastric Adenocarcinomas: Did Tumor Budding Play a Critical Role?
Authors: Lee Young Sub , Chong Yosep , Seo Kyung Jin , Yim Kwangil
Published: December 2023

Background: Endoscopic resection (ER) is a minimally invasive therapeutic approach for early gastric cancer (EGC), particularly for cases with a low risk of lymph node metastasis (LNM). Tumor budding (TB) has gained attention as a potential prognostic indicator for LNM in EGC. Case Presentation: We report two cases—a 73-year-old and an 81-year-old male patient—who presented with gastric adenocarcinoma. Both patients had small-sized, differentiated, and intramucosal adenocarcinomas. However, high-grade TBs per high-power field under ×200 magnification at the invasive front and LNMs were found in both cases. Conclusions: These cases conformed to the post-ER observation guidelines of the current treatment protocol, yet demonstrated LNMs. We found that TB could serve as an effective prognostic marker for LNM compared to traditional risk factors. The aim of this study is to re-examine the ability of TB to predict LNM in EGC, thereby providing an impetus for reconsideration and potential revision of the current treatment guidelines for EGC.
Waldenström’s Macroglobulinemia and Cryoglobulinemic Glomerulonephritis: An Unusual Case of Monoclonal Gammopathy of Renal Significance
Authors: De La Flor José C. , Sulca Jesús de María , Rodríguez Pablo , Villa Daniel , Sandoval Edna , Zamora Rocío , Monroy-Condori Maribel , Lipa Roxana , Perez Henry , Cieza Michael
Published: December 2023

Cryoglobulins are immunoglobulins that precipitate at temperatures below 37 °C and dissolve upon reheating. They can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation that occurs in patients with monoclonal gammopathy, specifically Waldenström’s macroglobulinemia. We present the case of a 52-year-old patient with a history of cutaneous vasculitis and hypothyroidism, who presented with generalized edema, moderate anemia, hypercholesterolemia, nephrotic range proteinuria of 12.69 g/day, microhematuria, arterial hypertension, and hypocomplementemia via the classical pathway, without acute kidney injury and with negative serological studies and positive cryoglobulins in the second determination. Serum and urine protein electrophoresis and immunofixation studies showed a monoclonal band of IgM and kappa light chain. Renal biopsy was consistent with cryoglobulinemic glomerulonephritis. In the context of dysproteinemia and cryoglobulinemic glomerulonephritis, bone-marrow aspiration and biopsy were performed, leading to the diagnosis of Waldenström’s macroglobulinemia. Monoclonal gammopathies have been described in association with type I cryoglobulinemias. This described association is uncommon, which is why we present this case, along with a review of the literature.
Research Progress on the Creep Resistance of High-Temperature Titanium Alloys: A Review
Authors: Liu Zhuomeng , Xin Shewei , Zhao Yongqing
Published: December 2023

High-temperature titanium alloys are one of the most important research directions in the field of high-temperature aerospace alloys. They are mainly used in high-temperature-resistant components, such as blade disks, blades, and casings of aero-engines, and are key materials in a new generation of high thrust-to-weight ratio aero-engines. In the service environment of engineering applications, the creep resistance of high-temperature titanium alloys is one of the most important characteristic indicators. This paper reviews and analyzes the research status and progress on the creep properties of typical high-temperature titanium alloys in service in recent years. The effects of the creep parameters, alloy composition, and microstructure on the creep behavior of high-temperature titanium alloys are discussed, and various possible mechanisms for increasing the creep resistance of high-temperature titanium alloys are summarized.
Effects of Temperature on Axial Crushing Behavior of Circular Multi-Walled Tubes
Authors: Zhang Zhijia , Feng Ruixuan , Wang Yongjing , Zhang Lijun , Zhang Qiancheng
Published: December 2023

In this work, the impact of temperature on the crushing performance of multi-walled tube (MWT) were investigated using a combined experimental, theoretical and numerical method. The MWT was fabricated using extrusion technology, and the temperature-dependent axial crushing experiment was performed on a hydraulic testing machine. The results show that the peak crushing force (PCF), the mean force (Pm) and the specific energy absorption (SEA) decreased near-linearly by 21.7%, 30.7% and 30.7% as the temperature increased from 25 °C to 250 °C, while the crushing load efficiency (CLE) was insensitive to temperature. The average forces obtained via numerical prediction, theoretical analysis and experimental testing were basically consistent. The numerical results indicate that varied temperature alters the number of dominant wavelets and the relative lateral deflections of MWT. In addition, compared with the competitive structures, the energy absorption property of MWT is excellent at high temperatures.
From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates
Authors: Cheddadi Riadh , Yeramilli Venkata , Martin Colin
Published: December 2023

The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, prompting the development of new frameworks through epidemiological studies. Traditionally, it was believed that each individual harbored unique microbial communities acquired early in life, evolving over the course of their lifetime, with little acknowledgment of any prenatal microbial development, but recent research challenges this belief. The neonatal microbiome’s onset, influenced by factors like delivery mode and maternal health, remains a subject of intense debate, hinting at potential intrauterine microbial processes. In-depth research reveals associations between microbiome profiles and specific health outcomes, ranging from obesity to neurodevelopmental disorders. Understanding these diverse microbiome profiles is essential for unraveling the intricate relationships between the microbiome and health outcomes.
Structural Inhomogeneities and Nonlinear Phenomena in Charge Transfer under Cold Field Emission in Individual Closed Carbon Nanotubes
Authors: von Gratowski S. V. , Kosakovskaya Z. Ya. , Koledov V. V. , Shavrov V. G. , Smolovich A. M. , Orlov A. P. , Denisjuk R. N. , Wang Cong , Liang Junge
Published: December 2023

The structure and phenomena arising from charge transfer in cold field emission mode in a single closed carbon nanotube (CNT) under cold field emission conditions are studied. Inhomogeneities of the structure of CNT in the form of two types of superlattices are found by studying microphotographs obtained by AFM, SEM, and TEM. The features of charge transfer in a quasi-one-dimensional carbon nanotube emitter with a small gap between the anode and cathode are studied under conditions of low-voltage field emission. It is established that the I-V characteristics reveal voltage thresholds and resonant peaks, which are associated with the opening of conduction channels in the region of van Hove singularities. In the region of peaks in the I-V characteristics, the emission current exceeds the one calculated using the Fowler–Nordheim (F-N) function by one to three orders of magnitude. The I-V characteristic is not that the curve straightens in F-N coordinates. It is found that the peaks in the I-V characteristics have distinct regions of negative differential conductivity.