bluuebunny/crossref_metadata_2025 huggingface dataset:
THE INFLUENCE OF SILICON ELEMENT-ADDED DLC FILM ON Ti-6Al-4V
Authors: Moolsradoo Nutthanun , Watanabe Shuichi
Published: June 2023

Silicon added diamond-like carbon films fabricated from C2H2:TMS mixture were used to study the influence of silicon content on the deposition and tribological properties of films prepared on Ti-6Al-4V substrate by using plasma-based ion implantation (PBII). The structure of the film was analyzed by Raman spectroscopy. Hardness and elastic modulus of the film were measured by nano-indentation hardness tester. Tribological propertiesof the film were performed by using ball-on-disk friction tester. The results indicate that with the increasing silicon content in the pure DLC film, the friction coefficient increases. The hardness and elastic modulus of Si-DLC film can increase to a value of up to 31.1 GPa and 200.1 GPa with a silicon content of 13.1 at.%. This is because the greater C content. The Si-DLC films with Si content of 13.1 at.% (C:Si/1:2) and 14.3 at.% (C:Si/1:6) shows a low friction coefficient of 0.2, which is considerable improvement in the tribological properties. This is due to the high hardness and elastic modulus.
Influence of biologics on the productivity of winter wheat varieties under irrigation conditions
Authors: PANFILOVA Antonina , KORKHOVA Margaryta , MARKOVA Nataliia
Published: June 2023

The aim of the research was to determine the influence of varietal characteristics, pre-sowing seed treatment and irrigation on the yield of winter wheat (Triticum aestivum L.). Experimental studies were carried out in the conditions of Mykolayiv National Agrarian University (Ukraine) during 2019-2022 yrs. It was found that among the studied variety of winter wheat, the highest grain yield was distinguished by the variety ‘Ozerna’ and ‘Duma Odes’ka’. On average, for pre – sowing seed treatment and irrigation options, these variety formed yields at the level of 6.78 and 6.95 tha–1, which was higher than the grain yield of ‘Anatoliya’ variety by 4.1 up to 6.5%, and then the yield of ‘Ovidii’ variety by 3.9 up to 6.3%. It was proved that preparations for pre-sowing seed treatment contributed to the formation of more productive stems and grain mass from one ear in winter wheat plants. So, on average, over the years of research, variety and irrigation options, for the use of Azotofit-R, the number of productive stems increased by 34-74 PCs./ m2 compared to other seed treatment options. At the same time, the yield of winter wheat grain was also slightly higher with the use of Azotofit-R biologics. It was found that the use of irrigation provided an increase in grain yield by 1.66-2.19 tha–1 or 23.1-27.2%, depending on the studied winter wheat variety. At the same time, the ‘Duma Odes’ka’ variety had a higher grain yield under irrigation (8.06 tha–1), while in conditions without irrigation, a slightly higher grain yield was formed by plants of the ‘Ozerna’ variety (5.87 tha–1). On average, over the years of research, the highest yield of winter wheat grain was provided by the cultivation of the ‘Duma Odes’ka’ variety for pre-sowing seed treatment with Azotofit - R biologics and irrigation–8.38 tha–1.
Environmental stress tolerance, hydro-distilled essential oils characteristics and biological activities of Eucalyptus torquata Luehm.
Authors: Ben RABEH Sonia , Ben YAHIA Kaouther , DHAHRI Samir , BELAÏD Souda , CHEMLALI Imen , Ben ROMDHANE Chokri , ROMDHANE Mehrez , SAADAOUI Ezzeddine
Published: June 2023

Eucalyptus has become one of the most widely planted genera in the world because of its tolerance to a wide range of soil types and climates, as well as for its many industrial, commercial and medicinal uses. Eucalyptus torquata Luehm. is a plantation species frequently planted in semi-arid and arid regions for its ecological, forestry, ornamental and melliferous interests. Based on literature, drought tolerance of this species was mostly directed to adaptation mechanisms. Physiological investigations reveal the importance of stomatal closure and increased solute contents suggesting that osmotic adjustment is one of the main responses to drought in E. torquata. On the other hand, it showed low sensitivity to salt stress. This paper also highlights the immense benefits of E. torquata which contains essential oils with variable chemical composition and rich essentially in 1,8-cineole, torquatone, α-pinene, trans-myrtanol, α-eudesmol, β-eudesmol, globulol, trans-pinocarveol and aromadendrene. These oils, as well as the methanol and aqueous extracts possess a wide variety of bioactivities of great importance which are particularly valuable as antibacterial and antifungal agents also have a strong toxicity against insects and mites in addition to antiproliferative and cytotoxic effects against different types of cancer cells.
Utilization of Pteridophyta species in Cyathea Park, Bali, as traditional medicine agents: A field study and meta-synthesis review
Authors: JULIASIH Ni Ketut Ayu , MERTHA ADNYANA I Made Dwi
Published: June 2023

Pteridophytes have been studied and preserved in botanical gardens. However, only a few have discovered and documented the medicinal properties of Pteridophyta species. This study aims to promote the utilization of Pteridophyta species in Taman Cyathea, Bali, as traditional medicine agents by conducting a comprehensive literature review with a novelty of 15 years (2008-2022) on the ethnopharmacology and species diversity of the plant division. This research was conducted by directly exploring Pteridophyta species collected in Taman Cyathea, Bali, and a meta-synthesis was carried out related to the potential use of these species as traditional medicinal agents. The STARLITE principle was used for the article search, and ENTREQ was used for transparency in reporting meta-synthetic results. The study was conducted by searching the databases with keywords set according to the inclusion criteria. Findings in the field showed that there were as many as nine species of Pteridophyta identified as having benefits as traditional medicine agents, including Cyathea contaminans (Wall ex Hook) Copel., Asplenium nidus L., Asplenium sp., Selaginella sp., Diplazium esculentum, Angiopteris evecta (G.Forst.) Hoffm, Cyathea sp., Nephrolepis hirsutula (Forst) C. Presl and Dicksonia blumei (Kunze) Moore. The results of the meta-synthesis obtained 49 articles that met the study criteria; leaves, shoots, roots, stems, and hairs were used for various purposes, including restorative materials, planting media, crafts, game materials, and food ingredients. Pteridophyta species treat fever, cough, anticonvulsant, antibacterial, anti-inflammatory, antipyretic, antidiuretic, immunomodulatory, antioxidant, insecticide, larvicide, diabetes, and antiretroviral diseases, among others, so their potential use as traditional medicine agents and candidates for standardized herbs or phytopharmaceuticals have promising prospects in the future. However, its pharmacological, phytochemical, and toxicity properties must be investigated further.
Gestão de projetos em empresas do setor de máquinas e implementos agrícolas do Estado de São Paulo
Authors: Gonçalves dos Santos Fabio Januário , Tahara Amaral Creusa Sayuri
Published: June 2023

O setor de máquinas e implementos agrícolas (MIA) tem importante papel para o avanço da economia brasileira por desenvolver implementos que tornam a produção agrícola mais eficiente e dinâmica. Este trabalho buscou analisar os perfis e maturidade em gestão de projetos (GP) nas indústrias de MIAs. Realizou-se um levantamento (e-survey) em 24 indústrias de MIAs paulistas. Foi aplicado um questionário baseado no modelo de maturidade Prado-MMGP. Para a análise de dados, utilizou-se a técnica de análise de cluster. Foram identificados quatro grupos de empresas, com perfis de maturidade em GP distintos: Grupo C1 (20,83% das empresas), caracterizado no nível 1 de maturidade (Muito fraco –perfil sem Gestão formal ); Grupo C2 (54,17% das empresas), caracterizado no nível 1 de maturidade, mas avaliado como Fraco – perfil Gestão inicial; Grupo C3 (representado por 1 empresa da amostra), caracterizado no nível 2 de maturidade (Regular – perfil Gestão em implantação); e Grupo C4 (20,83% das empresas), caracterizado no nível 3 de maturidade (Boa – perfil Gestão em aprimoramento). Apesar de produtos qualificados, a área de desenvolvimento de produtos (PDP) dessas empesas é deficiente, principalmente, pelo baixo nível de uso de práticas para apoio à GP. A definição dos perfis de maturidade em GP das empresas do setor de MIAs permitiu uma avaliação mais detalhada sobre o processo de GP, como um diagnóstico, identificando as melhores práticas e os pontos fracos que devem ser aprimorados, definindo, assim, um conjunto de ações a fim de se prepararem para futuros cenários de maior concorrência e desafios.
Bases teóricas para a construção do currículo na educação profissional e tecnológica
Authors: Da Silva Maria de Fátima , Fiori Ana Paula Santos de Melo
Published: June 2023

Em um cenário de crescente precariedade do mercado de trabalho e das condições de subsistência, definir uma base curricular única representa para o poder econômico mais que formação de mão de obra excedente. A BNCC estabelece um currículo limitado a competências, que favorecem a imposição da ideologia neoliberal, de modo a suprimir a resistência a retiradas de direitos e a redução de investimentos em políticas públicas. Permite propagar a falácia de que os problemas sociais podem ser superados através da educação financeira ou do empreendedorismo. Essas problemáticas envolvendo o currículo comum foram identificadas a partir de concepção epistemológica fundamentada no materialismo histórico-dialético. Diante do exposto, desenvolveu-se uma pesquisa de natureza básica, abordagem qualitativa e com objetivo exploratório, em que o levantamento de dados envolveu consultas a legislação educacional e revisão de literatura sobre Base Nacional Comum Curricular, Pedagogias Emancipatórias, formação omnilateral o eixo trabalho, ciência, tecnologia e cultura. Como resultados, este estudo demonstra o caráter inconstitucional e neoliberal que envolveu a aprovação da Base Nacional Comum Curricular (BNCC), propondo as Pedagogias de Freinet e Freire como alternativas a Pedagogia das Competências.
Modelagem de elementos e ligações de estruturas de aço combinando elementos finitos de viga e casca
Authors: Brugnaroto Samara Giacometti , Goedel Fábio , Pravia Zacarias M. Chamberlain
Published: June 2023

Ao realizar-se uma análise pelo método dos elementos finitos para avaliar o comportamento de uma estrutura de aço, diferentes tipos de elementos finitos podem ser utilizados tais como, elementos de viga, placas e ou cascas e sólidos. A escolha do tipo de elemento, bem como o tamanho do mesmo, são tarefas que devem ser realizadas pelo Engenheiro Estrutural, levando em conta o comportamento mecânico que se deseja simular, sendo que a formulação do elemento finito deve ser conhecida para que a escolha seja feita corretamente. No presente trabalho através de um caso de estudo de uma viga W com ligações em dupla cantoneira apoiada numa coluna, foram avaliadas três alternativas: (a) só usando elementos sólidos, (b) só usando elementos de casca e (c) misturando elementos de viga e casca. Os resultados mostram diferenças nos resultados que cabem nas tolerâncias de respostas estruturais para a análise desse tipo de estrutura, porém, apresentando uma vantagem na redução de número de graus de liberdade e por conseguinte no tempo computacional de realização das análises estruturais.
Os jogos digitais como facilitadores na aprendizagem: o jogo Plague inc. no desenvolvimento de competências e habilidades no 7º ano do ensino fundamental em ciências da natureza
Authors: Lobato André Poluboiaginof , De Souza Erivelto Luís , Pitangui Cristiano Grijó , De Oliveira Thiago Rodrigues
Published: June 2023

O artigo analisa como o professor compreende os benefícios e dificultadores dos jogos digitais na aprendizagem e de que modo o jogo Plague Inc. pode ser utilizado como recurso em sala de aula. Para compreender o entendimento dos professores referente aos jogos na educação, foi realizada uma pesquisa para averiguar as vantagens e principais dificuldades em utilizar este recurso. Como resultado, foi percebido que os docentes, de todas as áreas, compreendem os benefícios dos jogos como aliados, porém possuem barreiras em sua utilização pela falta de recursos, sejam eles estruturais ou dos próprios discentes. Sobre o Plague Inc, os docentes de Ciências da Natureza abordam que o jogo promove a investigação cientifica, as habilidades do Currículo Paulista e as competências da BNCC.
Relationships between common mental disorders, Burnout, and poor sleep quality in healthcare professionals working on the frontline of COVID-19 combat
Authors: Mendonça Filho Ricardo Ramos , Serafim Joan Lins , Diniz Pollyana Rodrigues , Dias Maria Eduarda da Silva , Angelo Rita di Cássia de Oliveira
Published: June 2023

The SARS-CoV-2 pandemic directly impacted the mental health of frontline health care workers fighting COVID-19. This study aims to investigate whether the working conditions of these professionals acted as predictors of common mental disorders, poor sleep quality, and burnout. Cross-sectional study conducted with 133 health professionals from three COVID-19 treatment units in the Agreste of Pernambuco-Brazil. The prevalence of depressive symptoms, anxiety, stress, and poor sleep quality were 26.3%, 36.8%, 28.6%, and 80%, respectively. The prevalence of high emotional exhaustion and high depersonalization was 47.4% and 57.1%, respectively. Weekly workload of more than 40 hours and high level of occupational stress were significant predictors of burnout and sleep disorders. The symptoms of mental illness among health professionals suffer a cumulative effect, and it is necessary to establish measures for the prevention of health problems among these workers.
El plazo máximo de interceptación telefónica según el tribunal supremo brasileño: la importancia de motivar las decisiones cautelares
Authors: Santoro Antonio Eduardo Ramires
Published: June 2023

La Ley 9.296/96 no fue clara al regular el plazo para la interceptación telefónica al no establecer una limitación en el número de extensiones. La interpretación original del STF, en el sentido de que no existía un número máximo, fue objeto de un nuevo abordaje en la sentencia del RE 625.263. El objetivo de este artículo es abordar el contenido de esta decisión por medio de un análisis de contenido de los votos emitidos por los Jueces. La Tesis Tema de Repercusión General 661 derivada de la sentencia del citado recurso acabó confiriendo mayor importancia a la exigencia de fundamentación de las resoluciones judiciales que conceden o prorrogan la medida. De esta forma, el impacto de los requisitos sobre la fundamentación de las decisiones y el problema del razonamiento per relationem fueron enfrentados directamente para concluir que la decisión del STF poco contribuyó para la solución de la cuestión.
A capela da pampulha e a igreja de águas, uma possível relação de irmandade
Authors: De Avelar Ana Paula Borghi , Toussaint Michel Alves Pereira , Da Cunha João Pedro Gaspar Alves
Published: June 2023

Este artigo tem como objetivo analisar dois templos católicos do século XX, um brasileiro e um português. São estes a Capela da Pampulha, a primeira igreja moderna brasileira e a Igreja de Águas, a primeira igreja a ser considerada moderna em Portugal. O projeto da Capela da Pampulha é do arquiteto brasileiro Oscar Niemeyer e foi inaugurada em 1943. Já o projeto da Igreja de Águas, é do arquiteto português Nuno Teotónio Pereira e foi inaugurada em 1957. Para além da grande distância da data de inauguração da igreja brasileira para a igreja portuguesa, podemos perceber pontos em comuns entre elas. Como a defesa da arquitetura religiosa moderna em seus países e uma possível inspiração por parte do arquiteto português em relação a arquitetura moderna brasileira. Relações estas que iremos tratar a seguir. Este artigo faz parte de uma investigação maior, de doutoramento, onde o foco principal está na comprovação de uma relação entre a arquitetura religiosa moderna brasileira e a arquitetura moderna religiosa portuguesa.
VOZES COERCITIVAS: O PODER MORAL DO MITO EM UMA COMUNIDADE REMANESCENTE DE QUILOMBO DA AMAZÔNIA TOCANTINA
Authors: Moia Mix de Leão , André Tamara Cardoso
Published: June 2023

O presente artigo analisa a importância do poder moral do mito presente em narrativas orais míticas em uma comunidade remanescente de quilombo da Amazônia tocantina, no Pará. O registro se dá a partir dos procedimentos metodológicos da História oral. A base de leituras centra-se nos pontos entre cultura, memória, identidade e moral. Para diálogo do tema, centralizamo-nos em autores, a exemplo de Bhabha (1998), Le Goff (1982), Hall (2009) e Vázquez (2003). Logo, pode-se dizer que as narrativas orais míticas, possuem uma moral implícita que serve de meio para assegurar um equilíbrio social entre os indivíduos e comunidade, visando garantir uma ordem social de acordo com os interesses coletivos por orientar hábitos, prescrições e vetos.
Carbon footprint of EMWA activities: A first estimate
Authors: Gomez-Escoda Blanca , Cicková Pavlína , Billiones Raquel
Published: June 2023

The Sustainability Special Interest Group (SUS-SIG) of EMWA was established in 2020 to support the United Nations 2030 agenda for sustainable development from the perspective of a not-for-profit professional organisation for medical writers and communicators. One of the SUS-SIG’s initiatives was to estimate EMWA’s carbon footprint, which can serve as a baseline for future carbon reduction strategies. This article presents the first estimate of EMWA’s annual greenhouse gas emissions, expressed as CO2 equivalent (CO2E).
Charting your way to the top: The 12 major milestones of freelance medical writing
Authors: Ash Sophie
Published: June 2023

As a freelance medical writer, it’s tough to know how well you’re doing – conventional career metrics don’t apply and you don’t have a boss keeping tabs on you. Yet, for your medical writing business to stand the test of time, with you at the helm, you need to be able to measure your success and know what’s next in terms of personal and professional growth. The good news is that countless freelancers have gone before you, leaving a trail of breadcrumbs to help you find your way. Learn how to identify and interpret these breadcrumbs and use them to your advantage by following the guided trail of important milestones outlined in this article to help you take your business to the next level at a pace you feel comfortable with.
The use of restorative justice for hate crime opportunities and limitations
Authors: Kozłowska Patrycja
Published: June 2023

The purpose of this article is to consider the possibilities and the legitimacy of using various forms of restorative justice in hate crime cases. Advantages of restorative justice programs as ways of responding hate crimes were especially explored and difficulties in implementing them for this category of acts were outlined. The conclusions drawn from the analysis might contribute to increased interest in the issue of combating hate crimes.
Legal problems in the field of implementation, the area of impact on the terrains of neighboring properties in the light of recent legal developments
Authors: Smarż Joanna
Published: June 2023

Determining the area of influence of the object on the area of neighboring real estates, in accordance with art 3 point 20 of the Building Law Act, causes many problems. The concept of this area, despite the legal changes made in 2015 and 2020, is still imprecise and may be subject to various assessments not only by the designer and the architectural and construction administration authority, but also by administrative courts. All the more so because in the phrase of "impact zone of the building" the term "development" (in the meaning of arrangement of the plot) has been changed to "development" (in the meaning of housing development), and both terms are used interchangeably in the jurisprudence.Each time, the purpose of the amendment was to narrow down the interpretation of restrictions related to the execution of construction works, and not, as previously assumed, also to the method of development, which was not related to the implementation of the investment, but referred to e.g. noise, smell, obscuring objects, restricting access to the road public. The consequence of the amendment to the above-mentioned regulation was also to limit the number of entities participating in the procedure for issuing a building permit.The impact zone of the building is determined on the basis of generally applicable regulations, which may introduce restrictions related to this building on the build up of the area. As a consequence of the above, this zone is determined individually in a specific case. The catalog of regulations constituting a reference point for determining the impact zone of the building on neighboring properties is not strictly defined, which also causes practical problems. Therefore, it is worth considering the definition of the impact zone of the building again, specifying, for example, the catalog of regulations that the authority should take into account when assessing the impact of the object on neighboring properties. Specifying such a catalog would certainly dispel any doubts that arise in this scope.
So called other facility on the land as a thing in the legal sense
Authors: Zaradkiewicz Kamil
Published: June 2023

The Civil Code of 1964 introduced a separate conceptual category of "facilities," which includes buildings, among others. In exceptional cases, such facilities are treated as separate things in the legal sense. The lack of a definition of "facilities" and, at the same time, treating only buildings as possible separate properties leads to the question of the material status of facilities that are not buildings. Moreover, it is unclear what criteria are to determine that a particular tangible legal asset is a "facility" in the civil law sense.Under current regulations, "facilities" in general cannot be considered real property in the legal sense. The only exception may be buildings, which constitute separate real estate in special cases. This is dictated in each case by the economic purpose of their operation. In this sense, both buildings and other facilities constitute a "main" thing in relation to the land itself. It is expedient to consider making significant changes in this regard. First, it is reasonable to prejudge that the status of an immovable thing separate from the land may have any facility, the ownership of which is associated with a specific limited, "purposeful" title to the exploitation of the land. Secondly, the derogation from the principle of superficies solo cedit cannot presuppose an "automatism" of treating as separate things any facilities, regardless of their purpose. Third, the needs of trading practice lead to the conclusion of the desirability of extending these exceptions to facilities located not only on the surface of the ground, but also under the ground. This refers to such facilities that serve transportation purposes (in particular, road, rail or subway tunnels), which justify the possibility of treating them for economic reasons as an immovable thing separate from the land.
How age and gender affect hemodynamic forces in healthy subjects
Authors: Airale Lorenzo , Votta Simona , Colomba Anna , Mingrone Giulia , Paladino Arianna , Astarita Anna , Cesareo Marco , Catarinella Cinzia , Novello Francesca , Milan Alberto
Published: June 2023

Aim: noninvasive echocardiographic analysis of blood-tissue interaction has recently been made possible by a sophisticated mathematical model. This model uses speckle-tracking technology to estimate instantaneous intraventricular gradients (IVPGs), which are represented as hemodynamic forces (HDFs). The aim of the present study is to examine how HDFs are affected by gender and age, providing reference value. Methods: 85 healthy subjects were recruited and underwent transthoracic echocardiography. Speckle-tracking analysis was performed from the three apical views, and the mitral annulus and left ventricular outflow tract were measured to compute HDFs. Longitudinal HDFs have been examined, decomposing them in amplitude and time parameters. Results: study population showed a median age of 47[25-60] years and 53% were female. Female patients showed lower LVMi (60.1±11.8mg/m2 vs. 71.4±16.8mg/m2, p=0.001), lower LVEDV (84.6±14.6ml vs. 108±20.7ml, p<0.001), and a lower E/e’ (7.26[6.47;7.78] vs. 5.31 [4.77;6.30], p<0.001). Nor systolic nor diastolic blood pressure differed between male and female patients (p NS for both). Several time parameters differed between gender: female subjects had a later systolic deceleration peak (38.7±4.21% vs. 34.8±4.31%, p<0.001) and a later diastolic deceleration peak (60.9±7.64% vs. 56.5±8.39%, p=0.015). No amplitude HDFs parameter was found to differ between gender (p NS for all). Regarding age, patients over50 years showed higher systolic (124±15.4mmHg vs. 115±10.8mmHg, p=0.008) and diastolic (75.2±8.99mmHg vs. 69.8±7.16mmHg, p=0.005) blood pressure, and higher E/e’ (7.41[6.91;8.58] vs. 5.58[4.81;6.56], p<0.001). HDFs time variables differed between patients under and over50 years: systolic ejection duration was longer in over50-group (27.8±3.44% vs. 25.6±3.48%, p=0.005), systolic deceleration duration was shorter in over50-group (7.69±1.48% vs. 8.54±1.97%, p=0.025) and systolic acceleration peak was earlier in over50-group (13.5±2.46% vs. 14.8±2.59%, p=0.020). Conclusion: Among healthy subjects, female patients showed later systolic deceleration peak and later diastolic deceleration peak. Subjects over50 years showed longer systolic ejection duration, shorter systolic deceleration duration and earlier systolic acceleration peak.
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability
Authors: Bencivenga Leonardo , Strumia Mathilde , Rolland Yves , Andrieu Sandrine , Vellas Bruno , De Souto Barreto Philipe , Rouch Laure , group for the MAPT/D. S. A.
Published: June 2023

Aim: Increased Blood Pressure (BP) Variability (BPV) may represent an alteration in BP physiological homeostatic patterns. Most physiopathological mechanisms underlying BPV are implicated in aging. Vascular aging is associated with chronic low-grade inflammation occurring in late life, known as "inflammaging", and the hallmark “mitochondrial dysfunction” associated to stress due to age-related disorders, which in turn might contribute to higher BPV and risk of cardiovascular disease. We aimed to determine whether plasma levels of the pleiotropic stress-related mitokine Growth/Differentiation Factor 15 (GDF-15) and two inflammatory biomarkers, Interleukin 6 (IL-6) and Tumor necrosis factor receptor 1 (TNFR-1), are associated with visit-to-visit BPV in a population of community-dwelling older adults. Methods: The study population consisted of 1,096 participants [median age 75 (72-78) years; 699 females, 63.7%] selected among community-dwelling participants aged ≥70 years from the MAPT study. Plasma blood sample was collected 12 months after enrolment and BP was assessed up to seven times over a subsequent 4-year period. Systolic BPV (SBPV) and diastolic BPV (DBPV) were determined through several indicators including the coefficient of variation (CV%) and taking into account BP change over time, the order of measurements and formulas independent of mean BP levels. Results: Higher values of GDF-15 were significantly associated with increased SBPV (all indicators) after adjustment for demographics, body mass index, MAPT randomization group, baseline systolic BP, antihypertensive drugs, diabetes mellitus, cardiovascular and non-cardiovascular comorbidities [adjusted 1-SD increase in GDF-15: β (SE)= 0.07 (0.04), p< 0.044, for CV%]. GDF-15 levels were not associated with DBPV. No significant associations were found between IL-6 and BPV, whereas TNFR1 was only partially related to DBPV. Conclusions: Unlike inflammation biomarkers, higher GDF-15 levels were associated with greater SBPV. Our findings support the age-related process of mitochondrial dysfunction underlying BP instability, suggesting that BPV might be a potential marker of aging.
Successful treatment with lomitapide in a patient with homozygous familial hypercholesterolemia and severe fatty liver disease
Authors: Cavicchioli Alessia , Lugari Simonetta , D’Avino Michela , Carubbi Francesca , Nascimbeni Fabio
Published: June 2023

Introduction and Aims: Homozygous-familial hypercholesterolemia (Ho-FH) is a rare condition due to biallelic mutations in low-density lipoprotein-receptor (LDL-R) genes characterized by high level of LDL-cholesterol (LDL-c) and huge risk of premature atherosclerotic cardiovascular disease (ASCVD), determining low quality of life and life expectancy. Lomitapide represents a therapeutic option for Ho-FH, but caution should be observed when used in fatty liver disease (FLD) and hypertransaminasemia since it is associated with onset/worsening of liver steatosis. We present a case of safe lomitapide therapy in an adult Ho-FH patient with pre-existing FLD. Case presentation: A 39-year-old man with severe hypercholesterolemia since childhood (LDL-c 405 mg/dl) and premature coronary heart disease history, was referred to our Modena Lipid Clinic. He presented an overt metabolic syndrome, FLD with hypertransaminasemia and elastosonographic significant liver fibrosis. Lipid-lowering-therapy (LLT) included rosuvastatin 20 mg, ezetimibe and evolocumab 140 mg twice a month without reaching LDL-c goal. Genetic analysis revealed homozygous pathogenic LDL-R gene mutation. Evolocumab was increased up to 420 mg twice a month and LDL-apheresis was started with quality of life worsening. Therefore, lomitapide 5 mg daily and low-fat diet were started, obtaining weight loss and lipid profile improvement. However, liver enzymes elevation higher than 5-fold was observed, leading to lomitapide discontinuation and baseline liver enzymes values restoration. After one-month wash-out, lomitapide was gradually reintroduced up to 5 mg daily without significant hypertransaminasemia recurrence, leading to LDL-c target achievement and LDL-apheresis discontinuation. Adherence to low-fat diet and weight loss resulted in FLD and fibrosis improvement. Conclusion: Ho-FH requires complex, combined treatment. Metabolic comorbidities co-existence makes Ho-FH management more difficult. Lomitapide can be safely used in Ho-FH patients with FLD and hypertransaminasemia, but strict follow-up of liver disease and a multidisciplinary approach are needed. Before lomitapide introduction, low-fat diet should be started advantageously and weight stabilization should be obtained.
Optimization of glucose control drives improvement of NAFLD independent of weight loss in people with T2D
Authors: Colosimo Santo , Tan Garry D. , Petroni Maria Letizia , Bertoli Simona , Marchesini Giulio , Tomlinson Jeremy W.
Published: June 2023

Aim. The mainstays for the treatment of non-alcoholic fatty liver disease (NAFLD) are lifestyle intervention with the aim of significant weight loss alongside aggressive cardiovascular risk reduction. NAFLD is tightly associated with both obesity and type 2 diabetes (T2D). In people with T2D, glucose lowering agents that promote weight loss have shown a beneficial impact on NAFLD based on histological features. However, it remains unclear as to whether glucose lowering can improve NALFD in patients with T2D, independent of weight loss. Methods. In a consecutively recruited population of 637 patients with T2D with HbA1c levels above treatment targets, DPP-IV inhibition, GLP-1RA therapy or SGLT2 inhibition was initiated, alongside lifestyle education with maintenance of exiting background glucose lowering treatment. We examined the longitudinal impact of the optimization of glycaemic control on fatty liver index (FLI) and Fibrosis score 4 (Fib-4) adjusting for changes in BMI and choice of glucose lowering regimen over a 12-month period. Results. Change in HbA1c and change in FLI correlated significantly in a linear regression analysis after adjustment for change in BMI, age, sex, and drug class (R=0.467, p=0.031). The greatest reduction in FLI was observed in patients with the largest reduction in HbA1c (p<0.0001). The probability of improvements in FLI with optimization of glycaemic control was similar with all 3 glucose lowering agents, despite differences in weight reduction. Similar relationships were observed examining the changes in glycaemic control and Fib-4. Conclusions. Significant reductions of HbA1c are associated with improvement in NAFLD independently from weight loss. These results suggest a prominent role for the optimization of glucose control in the management of coexistent NAFLD and T2D, especially in the ‘lean’ NAFLD and where significant weight loss may not be achieved.
Role of ASGR1 on obesity and metabolic syndrome
Authors: Svecla Monika , Moregola Annalisa , Da Dalt Lorenzo , Nour Jasmine , Baragetti Andrea , Uboldi Patrizia , Bonacina Fabeizia , Norata Giuseppe Danilo
Published: June 2023

Background: Obesity-related fat accumulation is linked to the metabolic syndrome and increases the risk of CVD by involving FFA, insulin resistance, and inflammation. Taking into account the findings from the third chapter, our goal was to assess the potential role of ASGR1 in metabolic reprogramming and immunoinflammatory state during obesity. Methods: After 20 weeks of high fat diet, flow cytometry, proteomics, lipid profile, glucose tolerance, and insulin tolerance were assessed in WT and ASGR1-/- mice (HFD). Additionally, metabolic parameters such as oxygen consumption, CO2 production, and food intake were measured during the diet. Results: After 20 weeks of HFD, the ASGR1−/− mice displayed a significant reduction in the circulating monocytes compared to WT. The body weight and food intake were comparable in between two groups. The adipose tissue VAT was significantly increased in ASGR1-/- compared to WT mice (WT 3.2%±0.8%, ASGR1-/- 4.7%±1.2%, P-value<0.001). The proteomics revealed, n=3412 proteins were aligned from which 624 proteins were significantly differentially expressed on the liver of ASGR1-/- and WT mice under HFD. From prediction analysis the significant proteins that were increase in the liver of ASGR1-/- mice were necrosis, apoptosis, and inflammation compared to the WT. Additionally, a significant downregulation in proteins protein expression involved in fatty acid synthesis and fatty acid uptake, except the increased expression of fatty acid coenzyme A ligase (FATP5), which belongs to very long chain acyl-CoA synthetases, capable mediation the transport of long chain fatty acids. Conclusion: Our findings indicate that ASGR1 deficiency causes increased inflammation and changes in metabolic pathways when subjected to HFD. This can also have an impact on the synthesis of apolipoproteins secreted in plasma.
In vitro and in vivo studies on novel pcsk9 inhibitors as pharmacological approach for the treatment of alzheimer’s disease
Authors: Ugolotti Martina , Papotti Bianca , Zimetti Francesca , Zanotti Ilaria , Bodria Martina , Vilella Antonietta , Giuliani Daniela , Giannessi Lisa , Elviri Lisa , Lupo Maria Giovanna , Ferri Nicola , Radi Marco , Bernini Franco
Published: June 2023

Aim: Impairment of cholesterol homeostasis is one of the multiple etiopathological mechanisms at the origin of both cardiovascular and neurodegenerative diseases. The PCSK9 protein, known for its role in the degradation of hepatic LDLR and plasma cholesterol regulation, is expressed also in the CNS, where it exacerbates -amyloid neurotoxicity and reduces neuronal cholesterol uptake, suggesting an involvement in AD. This study proposes an in vitro screening of molecules (MR) with inhibitory activity on PCSK9, selecting the best compounds to test their activity on cerebral cell models and their in vivo tolerability. Methods: 30 newly synthesized compounds were tested at increasing concentrations on human hepatoma cells (HepG2) to evaluate their cytotoxicity and efficacy in inhibiting PCSK9. MR-3 was tested on human neuroblastoma cells (SH-SY5Y) overexpressing PCSK9 to assess neurotoxicity and cholesterol uptake. Cytotoxicity was determined through MTT assay; PCSK9 secretion was quantified with an ELISA kit; and radioisotopic techniques measured cholesterol uptake . Three compounds were selected to be tested in vivo on C57BL/6 mice at a dose of 40 mg/Kg for 7 days to evaluate: tolerability with SHIRPA test; plasma lipid profile by ELISA assay; biodistribution in plasma and brain through LC-MS/MS. Results: Among the tested compounds, MR-3, MR-532, MR-533 demonstrated no sign of cytotoxicity and the greatest efficacy on HepG2 cells (IC50=1.7μM; 5.7μM; 6.1μM). Neuronal cholesterol uptake was restored after treatment with MR-3 at 10μM (p<0,05). MR-3, MR-532, and MR-533 exhibited good in vivo tolerability; MR-3 and MR-532 were detected in plasma and brain tissue. Conclusions: Preliminary in vitro screening allowed the identification of MR-3, MR-532, MR-533 as promising PCSK9 inhibitors. The outcome of MR-3 on neuronal cholesterol uptake may suggest a neuroprotective effect to be further investigated. In vivo treatment with selected inhibitors shown absence of toxicity, however, it is necessary to bring proof of efficacy.
Resgate do Hiperdia em uma Unidade Básica de Saúde no Estado de Pernambuco
Authors: Antão Francisca de Alencar , Souza Kayo Matheus Rodrigues de , Oliveira Letícia Ferreira de , Neto Waldemar de Brito Cavalcanti , Mendonça Cristyane Nathália Gomes
Published: June 2023

O Diabetes Mellitus e a Hipertensão Arterial Sistêmica se caracterizam como uma epidemia global. Objetivou-se relatar a experiência dos acadêmicos da Faculdade de Medicina de Olinda, com relação ao retorno das atividades do grupo Hiperdia, programa criado pelo Ministério da Saúde. Trata-se de um estudo descritivo, tipo relato de experiência, de abordagem crítico reflexiva de uma atividade teórico-prático realizada em maio de 2022, na Unidade Básica de Saúde de Igarassu- PE. Através de uma ação de educação em saúde, orientou-se acerca da importância de hábitos alimentares saudáveis, aumento da prática de atividade física e do acompanhamento terapêutico e medicamentoso para o controle e/ou tratamento dessas doenças crônicas. Por fim, constatou-se um déficit em relação ao entendimento das patologias em questão.
Acompanhamento de Pacientes com Transtorno do Espectro Autista e Síndrome de Down em ambulatório de genética médica
Authors: Valente Thiago José Monteiro Borges da Silva , Vieira Helder Elísio Evangelista , Farias Alessandra Nunes , Oliveira Híveny Cavalcanti Paiva , Santos Luciana Larissa Rodrigues dos , Martins Albert Eduardo Silva , Arruda Paula Stelita Cruz de
Published: June 2023

O diagnóstico precoce do Transtorno do Espectro Autista (TEA) e/ou Síndrome de Down (SD) em crianças e o seu acompanhamento ambulatorial são essenciais para o seu desenvolvimento e manutenção da qualidade de vida. O objetivo deste trabalho é relatar a experiência dos discentes da Liga de Genética Médica da Faculdade de Medicina de Olinda, no acompanhamento ambulatorial desses pacientes no Município de Olinda-PE, durante março a novembro de 2022. Os alunos puderam aperfeiçoar o seu atendimento, especialmente na Genética Médica, tornando-o mais humanitário e integral, devido à crescente demanda desses pacientes que necessitam, pelas suas comorbidades, do encaminhamento para outras especialidades, de forma a proporcionar um acompanhamento regular e especializado.
As potencialidades da educação em saúde dialógica na atenção secundária
Authors: Soares Alane Andrade , Costa Ana Paula Rocha da , Bispo Andressa Joyce Pereira , Evangelista Letícia Maria Silva , Junior José Mário Ferreira da Rocha , Sá Jéssica Rodrigues Correia e , Sobel Juliana Figueiredo
Published: June 2023

Introdução: As práticas de educação em saúde são importantes nos diferentes contextos vivenciados pelos usuários do Sistema Único de Saúde, já que a dificuldade de acesso ao conhecimento os tornam distantes do entendimento do processo saúde-doença. Objetivo: Descrever os impactos observados em uma ação em saúde acerca da Monkeypox. Metodologia: A ação foi desenvolvida por estudantes da Faculdade de Medicina de Olinda com usuários à espera de atendimentos nas clínicas-escolas, havendo discussões mediante diálogos interativos. Resultados: Observou-se uma população receptiva às discussões que impactam diretamente seu cotidiano, contribuindo com o diálogo, expondo ideias e questionamentos pré-existentes. Considerações finais: As discussões em saúde tornam o indivíduo protagonista do processo saúde-doença, estimulando a busca pelo bem-estar por meio da autonomia.
Estratégia de Educação em Saúde na Prevenção das Infecções Sexualmente Transmissíveis
Authors: Farias Alessandra Nunes , Cavalcanti Giovana Teixeira Martins , Vieira Helder Elísio Evangelista , Lima Pedro Guilherme Fernandes , Dourado Synara Ricardo , Sá Jéssica Rodrigues Correia e
Published: June 2023

As estimativas de incidência das Infecções Sexualmente Transmissíveis atingem os diversos públicos e possuem múltiplas etiologias, sintomatologias e complicações que podem ser prevenidas, diagnosticadas e tratadas precocemente através das práticas de educação em saúde na atenção primária. O objetivo do estudo foi descrever a experiência da educação em saúde vivenciada por estudantes na Atenção Primária de acordo com a proposta metodológica de educação defendida por Paulo Freire. Foi notória a boa aceitação da proposta pela população, a qual demonstrou interesse na troca de conhecimentos, participação ativa durante todo o processo e palavras de agradecimento pelo espaço ofertado.
Relação entre Doença Arterial Coronária e Artrite Reumatoide
Authors: Lages Dolly Brandão , Pacífico Fernando Augusto , Farias Michelle Alves de , Claudino Antonia Raiane Silva , Marins Giovanna Sherly de Sá Guedes , Santos Liliam de Souza , Paixão Eduardo Lins
Published: June 2023

Artrite Reumatoide (AR) é uma doença inflamatória que afeta as articulações, levando a destruição tecidual, dor e deformidades. A inflamação acelera o processo de aterosclerose ocasionando o desenvolvimento da doença arterial coronariana (DAC). Relatamos o caso de um paciente de 64 anos, portador de AR há 25 anos, que evoluiu com a doença persistentemente ativa e com marcadores de inflamação acima do valor de normalidade, sendo diagnosticado com redução luminal na artéria descendente anterior e submetido à angioplastia coronária. A prevalência de DAC com risco de morte prematura é aumentada nesses pacientes devido a cronificação do processo inflamatório. Logo, a avaliação cardiovascular anual é imprescindível nos portadores de AR.
Cannabidiol interactions in the voltage-gated calcium channel by molecular docking
Authors: Arruda Gisele Evelin de Jesus , Júnior Gidelson José Silva , Mendes Nathalia Napoli , Mendes Gustavo Napoli , Costa Alessandra Emertice de Almeida , Fernandes Luana Carmélia de Lira , Silva Joelmir Lucena Veiga da
Published: June 2023

Objective: to analyzer the interactions of cannabidiol in the CaV3.2 through molecular docking. Methodology: this is a research with in silico approach, which CBD and gabapentin (GBP) were employed as test substances, and CaV3.2 channel the target protein. Molecular docking experiments were realized by Dockthor. The drugs simulations were classified in order of highest affinity in the channel. The binding energy scores were linked using Student t-test by GraphPad Prism software, the values were significantly different (p < 0.05). Results: the spatial positions into CBD or GBP and CaV3.2 were 1,000,000 conformers. Our data showed that the binding energies of CaV3.2 channel and CBD or GBP were - 6.493 ± 0.07 and - 6.842 ± 0.19 kcal/mol, respectively. Those values did not show statistically difference (p = 0.08), suggesting that both drugs bind similarly the CaV3.2, however both chemicals connected the distinct sites. Conclusions: CBD binds to CaV3.2, which corroborates its blockade channel. Those data support the analgesic effect of CBD through the neuronal inhibitory pathway.
Tracing the Sources of River Waters Using Stable Isotopes (δ18O and δ2H) in Two Mountainous Watersheds, Southern Western Ghats, India
Authors:   National Centre for Earth Science Studies, Thiruvananthapuram-695011(KL), India, Raj Vipin T. , Gayathri J.A. , Sharma R.K. , Redkar B.L. , Sreelash K. , Padmalal D. , Sajan K.
Published: June 2023

Stable isotopes of oxygen (δ18O) and hydrogen (δ2H) are useful tools to characterize and monitor the hydrological processes in aquatic ecosystems.The present study uses δ18O and δ2H data from two small catchment rivers such as the east-flowing Bhavani river and the west-flowing Thuthapuzha River in southern Western Ghats to get an insight into the water cycle dynamics and sources of water.The Bhavani River drains through the semi-arid, lee-ward side of the Western Ghats and shows a markedly depleted isotopic composition as compared to the Thuthapuzha River which drains through the humid, windward side of the Western Ghats. The isotopic systematics are strongly influenced by the southwest monsoon (SWM) and the northeast monsoon (NEM) rainfalls. However, during the pre-monsoon (PRM) season, the isotopic composition in these river waters is governed mainly by the baseflow and evaporative processes. Both the river basins experience a higher vapour recycling effect in their headwaters. The NEM rainfall contains a considerable amount of recycled vapour, which is evident from the observed high d-excess values. Whereas the SWM rain events show the dominance of the original sea moisture source. There is a distinct difference in the isotopic ratios and d-excess values between the SWM (d-excess: Bhavani River 10.29 ± 1.29‰; Thuthapuzha River 10.52 ± 2.78‰) and the NEM (d-excess: Bhavani River 15.15 ± 0.92‰; Thuthapuzha River 12.67 ± 4.49‰) seasons, with the predominance of lighter isotopes in the latter period. In general, the seasonal and spatial differences in isotopic composition in the Bhavani River (δ18O: PRM−5.42 ± 1.76‰; SWM−4.16 ± 0.77‰; NEM -4.73 ± 0.76‰) and the Thuthapuzha River (δ18O: PRM −4.26 ± 0.67‰; SWM −2.54 ± 0.76‰; NEM −2.68 ± 0.96‰) indicate that precipitation (atmospheric source) as the major source of water in the monsoon (SWM and NEM) season, while the base flow contribution from groundwater has a major stake in PRM season. Keywords: Stable Water Isotopes, d-excess, Climate Gradient, Base Flow Discharge, Western Ghats, Southwest India
Fundamentos de Medicina Crítica y Cuidados Intensivos Vol. 1
Authors: Rodríguez Manzano Fander Roberto , Díaz Barreiro Ivanna Alejandra , Neira Vera Mayra Alejandra , Jácome Gavilanez Nathaly Michelle , Fuentes Guerrero Ivan Xavier
Published: June 2023

"Fundamentos de Medicina Crítica y Cuidados Intensivos Vol. 1" es una obra clave para aquellos en el campo de la medicina intensiva, ya sean médicos intensivistas, residentes en formación, enfermeros especializados o estudiantes de medicina. Esta obra proporciona un enfoque sólido y detallado sobre los principios esenciales del cuidado de los pacientes gravemente enfermos.
Actualización en Atenciones Médicas Vol. 18
Authors: Bungacho García Karla Alejandra , Proaño Sánchez Mónica Elizabeth , López Pérez Valeria Lisseth , Gaibor Mestanza Pamela Margoth , Balcázar Peñaherrera David Fabricio , Villacrés Mosquera Jennifer Paola , Laso Gualacata Mónica Isabel , Benavides Álvarez Juan Carlos , Ormaza Buitrón Diana Elizabeth , García Ostaiza Génesis Liliana , Miranda Villagómez Andrea Fernanda , Falconi Toro Daniel Andres , Esquivel Uribe Dubeth Ximena , Mendoza Zambrano Johanna Tahily , Tipán Quishpe Diana Matilde , Zatán Miñarcaja María Viviana , Dávila Torres Michelle Katherine , Altamirano Duque Karol Elizabeth
Published: June 2023

La presente obra es el resultado del esfuerzo académico de un grupo de profesionales de la salud, quienes han recopilado la información disponible con la evidencia científica más actualizada sobre temas que esperamos ayuden a los profesionales de la salud y a médicos en formación interesados en profundizar sus conocimientos sobre patologías frecuentes que pueden presentarse dentro de su ámbito profesional.