bluuebunny/crossref_metadata_2025 huggingface dataset:
A scoping review of methods to measure and evaluate citizen engagement in health research
Authors: Shahid Anmol , Lalani Inara N. , Rosgen Brianna K. , Sept Bonnie G. , Longmore Shelly , Parsons Leigh Jeanna , Stelfox Henry T. , Fiest Kirsten M.
Published: December 2022

Background

Citizen engagement, or partnering with interested members of the public in health research, is becoming more common. While ongoing assessment of citizen engagement practices is considered important to its success, there is little clarity around aspects of citizen engagement that are important to assess (i.e., what to look for) and methods to assess (i.e., how to measure and/ or evaluate) citizen engagement in health research.

Methods

In this scoping review, we included peer-reviewed literature that focused primarily on method(s) to measure and/or evaluate citizen engagement in health research. Independently and in duplicate, we completed title and abstract screening and full-text screening and extracted data including document characteristics, citizen engagement definitions and goals, and methods to measure or evaluate citizen engagement (including characteristics of these methods).

Results

Our search yielded 16,762 records of which 33 records (31 peer-reviewed articles, one government report, one conference proceeding) met our inclusion criteria. Studies discussed engaging citizens (i.e., patients [n = 16], members of the public [n = 7], service users/consumers [n = 4], individuals from specific disease groups [n = 3]) in research processes. Reported methods of citizen engagement measurement and evaluation included frameworks, discussion-based methods (i.e., focus groups, interviews), survey-based methods (e.g., audits, questionnaires), and other methods (e.g., observation, prioritization tasks). Methods to measure and evaluate citizen engagement commonly focused on collecting perceptions of citizens and researchers on aspects of citizen engagement including empowerment, impact, respect, support, and value.

Discussion and conclusion

We found that methods to measure and/or evaluate citizen engagement in health research vary widely but share some similarities in aspect of citizen engagement considered important to measure or evaluate. These aspects could be used to devise a more standardized, modifiable, and widely applicable framework for measuring and evaluating citizen engagement in research.

Patient or public contribution

Two citizen team members were involved as equal partners in study design and interpretation of its findings.

Systematic review registration

Open Science Framework (10.17605/OSF.IO/HZCBR).
Efficacy of native strains of entomopathogenic nematode, Heterorhabditis indica against the fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae) from India
Authors: Shinde Swati P. , Ingole D. B. , Biradar V. K. , Gokte-Narkhedkar Nandini , Lavhe N. V. , Thube Shivaji H. , Shah Vivek , Prasad Y. G.
Published: December 2022

Background

The fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), is a notorious polyphagous pest that has recently invaded India in 2018. Within a short period, this pest has spread throughout the country, causing a significant damage to maize. In order to manage this menace, farmers rely on chemical insecticides, but due to concealed feeding nature of this pest insecticides remain ineffective in reaching the target site. In this context, the present study aimed to isolate, characterize and evaluate the reproductive potential of the native strains of entomopathogenic nematode, Heterorhabditis indica against larval instars of S. frugiperda under laboratory conditions.

Results

Two strains of H. indica isolated and characterized from the rhizosphere of mango and curry leaf trees were designated as CICR-HI-MN and CICR-HI-CL, respectively. Both strains, CICR-HI-CL and CICR-HI-MN showed differential mortality against 3rd (LC50 value of 21.65, 48.91 IJs/larva), 4th (LC50 value of 25.46, 52.36 IJs/larva) and 5th (LC50 value of 59.20, 71.04 IJs/larva) instar larvae of S. frugiperda, respectively. The instar-wise mortality of S. frugiperda showed that 3rd instar was relatively more susceptible compared to 4th and 5th instar larvae. In terms of efficacy, CICR-HI-CL was almost twice effective than CICR-HI-MN when LC50 and LC95 values of 3rd instar larvae were compared. However, the reproductive potential of both the strains was significantly higher against 5th instar than the 3rd and 4th instar larvae. Strain CICR-HI-CL was more effective in larval mortality, while nematode reproduction was higher in CICR-HI-MN.

Conclusions

Native strains of H. indica evaluated in the present study were found effective against larval instars of fall armyworm, S. frugiperda. Higher reproduction on 5th instar larvae demonstrates the ability of these strains to multiply, sustain and perpetuate on late instars of this polyphagous pest and may serve as viable option in integrated pest management program.
Efficacy of the entomopathogenic fungi Beauveria bassiana and Lecanicillium muscarium in the control of the tomato leaf miner, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)
Authors: Chouikhi Sabrine , Assadi Besma Hamrouni , Lebdi KaoutharGrissa , Belkadhi Mohamed Sadok
Published: December 2022

Background

Among the phytosanitary problems, affecting tomato crops in greenhouses heated by geothermal water in southern Tunisia, the tomato leaf miner, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is gaining prominence from year to year.

Results

This study determined the susceptibility of eggs, second-instar larvae of T. absoluta to commercial formulations of the entomopathogenic fungi (EPF) Beauveria bassiana and Lecanicillium muscarium at different doses (1010, 109, 108, 107 and 106 spores/ml). Pathogenicity tests were carried out under controlled laboratory conditions at 27 ± 1 °C, and RH of 75 ± 5%, showed that the three commercial formulations of B. bassiana R444 (Bb-Protec®), B. bassiana ATCC 74,040 (Naturalis®) and L. muscarium Ve6 (Mycotal®) were effective against eggs and second instar larvae of T. absoluta. Mortality rates of eggs and larvae were high with increasing the concentrations of the fungi. B. bassiana ATCC 74,040 was the most effective one, with an egg mortality rate of (71.42%) and larval mortality was greater than (80%), at the highest concentration of 1010 spores/ml. The lethal concentration required to kill 50% of eggs was 1.56 × 108, 1.73 × 109 and 1.09 × 1010 conidia/ml for B. bassiana ATCC, B. bassiana R444, and L. muscarium, respectively. After 7 days, the median lethal concentration (LC50) values against larvae were the lowest for B. bassiana ATCC with 2.63 × 107 and 4.76 × 106 conidia/ml by way 1 and way 2 treatments, respectively. Thus, these three formulations affected the emergence of pest’s adults. The fungi significantly reduced pupation and adult emergence. Only 50.25, 60.15 and 69.16% of T. absoluta adults emerged in the treatments with B. bassiana ATCC, B. bassiana R444, and L. muscarium, respectively.

Conclusions

Biological performances of the EPF showed the role of a biological control agent that can be played against T. absoluta within the framework of an Integrated Pest Management program.
A Computed Tomography-based Radiomics Nomogram for Predicting Osteoporotic Vertebral Fractures: A Longitudinal Study
Authors: Wang Miaomiao , Chen Xin , Cui Wenjing , Wang Xinru , Hu Nandong , Tang Hongye , Zhang Chao , Shen Jirong , Xie Chao , Chen Xiao
Published: December 2022

Context

Fractures are a serious consequence of osteoporosis in older adults. However, few longitudinal studies have shown the role of computed tomography (CT)-based radiomics in predicting osteoporotic fractures.

Objective

We evaluated the performance of a CT radiomics-based model for osteoporotic vertebral fractures (OVFs) in a longitudinal study.

Methods

A total of 7906 individuals without OVF older than 50 years, and who underwent CT scans between 2016 and 2019 were enrolled and followed up until 2021. Seventy-two cases of new OVF were identified. A total of 144 people without OVF during follow-up were selected as controls. Radiomics features were extracted from baseline CT images. CT values of trabecular bone, and area and density of erector spinae were determined. Cox regression analysis was used to identify the independent associated factors. The predictive performance of the nomogram was assessed using the receiver operating characteristic curve, calibration curve, and decision curve.

Results

CT value of vertebra (adjusted hazard ratio (aHR) = 2.04; 95% CI, 1.07-3.89), radiomics score (aHR = 6.56; 95% CI, 3.47-12.38), and area of erector spinae (aHR = 1.68; 95% CI, 1.02-2.78) were independently associated with OVF. Radscore was associated with severe OVF (aHR = 6.00; 95% CI, 2.78-12.93). The nomogram showed good discrimination with a C-index of 0.82 (95% CI, 0.77-0.87). The area under the curve of nomogram and radscore were both higher than osteoporosis + muscle area for 3-year and 4-year risk of fractures (P < .05). The decision curve also demonstrated that the radiomics nomogram was useful.

Conclusion

Bone radiomics is associated with OVF, and the nomogram based on radiomics signature and muscle provides a tool for the prediction of OVF.
Extensive Peritonectomy is an Independent Risk Factor for Cisplatin HIPEC-Induced Acute Kidney Injury
Authors: Liesenfeld Lukas F. , Quiring Eva , Al-Saeedi Mohammed , Nusshag Christian , Büchler Markus W. , Schneider Martin
Published: December 2022

Background

Cisplatin (CDDP)-containing hyperthermic intraperitoneal chemotherapy (HIPEC) is frequently applied in selected patients with peritoneal malignancies derived from ovarian cancer, gastric cancer, and primary peritoneal mesothelioma. HIPEC with CDDP increases perioperative morbidity, in particular by inducing acute kidney injury (AKI). Factors contributing to occurrence of AKI after intraperitoneal perfusion with CDDP have not been sufficiently evaluated.

Patients and Methods

Data from 63 patients treated with a CDDP-containing HIPEC regimen were retrospectively analyzed concerning demographics, underlying disease, surgery, and HIPEC details to evaluate risk factors of AKI. A preclinical rat perfusion model was applied to assess the influence of temperature, concentration, perfusate volume, perfusion flow rate, and extent of peritonectomy on drug absorption upon intraperitoneal CDDP perfusion.

Results

AKI occurred in 66.1% of patients undergoing CDDP-containing HIPEC, with total intraoperative fluid influx being a negative and the extent of parietal peritonectomy being a positive independent predictor of postoperative AKI. In a preclinical model, bilateral anterior parietal peritonectomy significantly increased systemic CDDP absorption by 1.6 to 2-fold. CDDP plasma levels in animals were significantly higher after both perfusion with increased CDDP perfusate concentrations and bilateral anterior parietal peritonectomy.

Conclusion

CDDP-containing HIPEC is associated with relevant morbidity owing to its systemic toxicity. Extent of parietal peritonectomy is an independent predictor of AKI. CDDP dose reduction should be considered in case of extensive parietal peritonectomy. Cytostatic drug concentrations in HIPEC perfusate should be paid more attention to than total dose per body surface area. Further clinical studies are needed to confirm the presented preclinical findings.
Το φαινόμενο του ντόπινγκ
Authors: Κανλής Παράσχος
Published: December 2022

Σκοπός της παρούσας μελέτης είναι να δείξει μέσα από μια κριτική οπτική, πώς το φαινόμενο του ντόπινγκ ως αποκλίνουσα αθλητική συμπεριφορά, αντιμετωπίζεται από την άτυπη μορφή του κοινωνικού ελέγχου τόσο στα πρωτογενή κοινωνικά συστήματα, όσο και από εκείνα του επίσημου κοινωνικού ελέγχου και να γνωστοποιήσει τα συστήματα σκέψης που ενισχύουν αυτό το φαινόμενο τον τρόπο δράσης και τις συμπεριφορές του. Η χρήση αθέμιτων μέσων, ουσιών και μεθόδων με σκοπό την επίτευξη καλύτερων αποτελεσμάτων στον αθλητισμό, αποτελεί μια κατάσταση που δύσκολα μπορεί να διευθετηθεί και απασχολεί ολόκληρη την παγκόσμια κοινότητα. Είναι δε ένα από τα σημαντικότερα αδικήματα τόσο στον αθλητισμό όσο και στο ευρύτερο κοινωνικό, πολιτικό και οικονομικό πεδίο καθώς αλλοιώνει και παραχαράσσει το αθλητικό αποτέλεσμα, έχει δε ανεπιθύμητες και αρνητικές επιπτώσεις στην υγεία των ανθρώπων, με τραγική ακόμη κατάληξη όπως είναι ο θάνατος. Η έρευνά μας αποτελείται από δυο θεματικές, κατά πρώτον εκείνη της εμπορευματοποίησης και της παραβατικότητας της εργασίας του ερασιτεχνικού αθλητισμού όπου προσπαθούμε να ερευνήσουμε ποιά είναι η σχέση μεταξύ συλλόγων, παραγόντων, προπονητών, αθλητικών φορέων και κυρίως κρατικών φορέων ως προς την εφαρμογή των νόμων, την ποινικοποίηση και την επέκταση του κοινωνικού ελέγχου. Στο πλαίσιο αυτό προσπαθούμε να ερευνήσουμε την εγκληματοποίση πράξεων που συμβαίνουν στον χώρο του ερασιτεχνικού αθλητισμού από την πλευρά της προστασίας των ανθρωπίνων δικαιωμάτων και κοινωνικής βλάβης, την δυνατότητα συμμετοχής ή αποκλεισμού των ατόμων σύμφωνα με τα κοινωνικό-οικονομικά και άλλα χαρακτηριστικά τους. Κατά δεύτερον εκείνη που εξετάζει το φαινόμενο του ντόπινγκ στον αθλητισμό, πως γίνεται ο χειρισμός του φαινομένου του ντόπινγκ και των εγκληματικών πράξεων που παράγονται από αυτό, από μέρους της επίσημης πολιτείας.
E-sport related intrinsic and extrinsic motivation in practice. Initial psychometric properties of the “E-sport and ME” questionnaire
Authors: Horoszkiewicz Krzysztof , Załęski Grzegorz , Horoszkiewicz Bartosz
Published: December 2022

Background. The popularity of eSports is rapidly increasing, and PC gamers are watched by crowds of spectators similarly to traditional sports.

The aim. E-Sport and ME questionnaire was created to assess motivation for playing video games and competing in tournaments.

Material and methods. The theoretical background was grounded in self-determination theory (SDT).

The results of 203 men aged 14 to 33 years (M = 20.4; SD = 3.4) were studied. Exploratory and confirmatory factor analyses (EFA and CFA) were conducted.

Results. Both EFA and CFA indicated two solid factors: extrinsic and intrinsic motivation [Comparative Fit Index = 0.995, Tucker Lewis Index = 0.994, Root Mean Square Error of Approximation = 0.046 (CI 0.00 – 0.08), Standardized Root Mean Square Residual = 0.075 (χ2 = 64.16, df = 53)]. Both scales had a high level of internal consistency (> α = 0.8). Respondents from professional e-sports clubs have higher extrinsic motivation than amateurs; intrinsic motivation takes place on similar level. 

Conclusions. The statistical analysis of e-sport and myself revealed a high level of internal consistency as well as the identification of two distinct factors. This could aid coaches and players in outlining the dominant type of motivation for playing video games. The shown version should be further explored and validated to increase its generalizability.
Existence results for fractional Brezis-Nirenberg type problems in unbounded domains
Authors: Shen Yansheng , Wang Xumin
Published: December 2022

In this paper we study the fractional Brezis-Nirenberg type problems in unbounded cylinder-type domains
\begin{align*}
\begin{cases}
(-\Delta)^{s}u-\mu\dfrac{u}{|x|^{2s}}=\lambda u+|u|^{2^{\ast}_{s}-2}u
& \text{in } \Omega,\\
u=0 & \text{in } \mathbb{R}^{N}\setminus \Omega,
\end{cases}
\end{align*}
where $(-\Delta)^{s}$ is the fractional Laplace operator with $s\in(0,1)$,
$\mu\in[0,\Lambda_{N,s})$ with $\Lambda_{N,s}$ the best fractional Hardy constant, $\lambda> 0$, $N> 2s$ and $2^{\ast}_{s}={2N}/({N-2s})$
denotes the fractional critical Sobolev exponent. By applying the fractional
Poincaré inequality together with the concentration-compactness principle
for fractional Sobolev spaces in unbounded domains, we prove an existence
result to the equation.
PRIORITAS BELANJA DANA KELURAHAN PADA DANA ALOKASI UMUM (DAU) TAMBAHAN KELURAHAN KEBUN BUNGA KOTA BANJARMASIN
Authors: Rizki Ryan Akhmad , Maulida Sri
Published: December 2022

Penelitian ini bertujuan untuk (1) mengetahui belanja kelurahan pada dana kelurahan Kebun Bunga Kecamatan Banjarmasin Timur, dan (2) mengetahui prioritas belanja kelurahan dalam membangun kelurahan Kebun Bunga.
Responden dalam penelitian ini ada 6 responden yang dianggap berpengaruh terhadap penentuan belanja kelurahan di Kelurahan Kebun Bunga yang digunakan dalam pengolahan data menggunakan metode AHP (Analytical Hierarchy Process).
Hasil penelitian ini menunjukkan bahwa kriteria alternatif Renstra Kecamatan, Sumber Daya Manusia (SDM), Kinerja Sebelumnya, dan Manfaat Kegiatan mempengaruhi penentuan prioritas belanja kelurahan dengan urutan nilai preferensi 28% Renstra Kecamatan, 17% Sumber Daya Manusia (SDM), 7% Kinerja Sebelumnya, dan 47% Manfaat Kegiatan. Berdasarkan kriteria alternatif tersebut preferensi pemilihan prioritas belanja Kelurahan adalah Sarana dan prasarana kelurahan 69%, dan pemberdayaan masyarakat 31%. Dengan kesimpulan yang paling dominan adalah sarana dan prasarana sebesar 69%.
ANALISIS TINGKAT EFISIENSI DAN TINGKAT PRODUKTIVITAS PADA BANK UMUM SYARIAH PERIODE 2015-2019
Authors: Putri Lisma Febriani , Pantas Pribawa E
Published: December 2022

ANALISIS TINGKAT EFISIENSI DAN TINGKAT PRODUKTIVITAS PADA BANK UMUM SYARIAH PERIODE 2015-2019
A INTERIORIZAÇÃO DA VIOLÊNCIA REVISITADA: reorganização espacial na distribuição dos homicídios entre os municípios do Rio de Janeiro (2011-2018)
Authors: De Mello Neto David Maciel , Ruediger Marco Aurélio
Published: December 2022

Esta pesquisa trata da evolução dos homicídios no Rio de Janeiro entre 2010 e 2018. Com fonte nos dados do SIM/DataSUS, na primeira parte descrevemos as linhas gerais da dinâmica capital x restante da região metropolitana x interior. Na segunda parte, estimamos as taxas médias de crescimento ao ano entre os 92 municípios fluminenses mediante um modelo de regressão generalizada multinível. De posse delas, analisamos, na terceira parte, a hipótese de autocorrelação espacial na distribuição de seus valores. Na quarta, exploramos, ainda que brevemente, algumas hipóteses causais contidas na literatura. Findamos como uma síntese dos achados e apontamentos para pesquisas futuras. A tese geral é de que entre 2011 e 2018 houve uma reorganização espacial na distribuição dos homicídios no Rio de Janeiro, que subiram indiscriminadamente em quase todos os municípios, sem uma tendência forte de contágio. Ao contrário, a maior parte das poucas exceções foram de municípios menos violentos que a média global, cercados por outros mais violentos. Quanto às causas, não foram encontradas associações significativas com os investimentos em segurança pública ou o desenvolvimento econômico municipal. O mais provável é que expansão dos mercados ilegais, tanto nas grandes como nas pequenas cidades, tenha levado ao aumento da violência.
MEIOS DE COMUNICAÇÃO E MODERNIDADE TARDIA: REFLEXÕES SOBRE O POPULISMO E O USO DOS MEIOS DIGITAIS
Authors: Dugnani Patrício , Macedo Roberto Gondo
Published: December 2022

Pretende-se, nesse artigo, refletir sobre o conceito de populismo em relação ao advento dos meios digitais de comunicação e suas plataformas como a internet e as redes sociais.Tomando essa ideia como princípio, esse artigo exploratório e teórico, será iniciado por uma reflexão sobre o conceito de populismo, relacionado ao momento contemporâneo, para buscar uma denominação, senão definitiva, pelo menos que possa sintetizar, por agora, uma ideia do que seria o populismo no momento da Modernidade Tardia. Definido, por fim, o conceito de populismo, o debate se voltará para a reflexão sobre esse fenômeno na Modernidade Tardia, e a relação com o uso dos meios digitais.
INFLUÊNCIA DA SUBSTITUIÇÃO DO AGREGADO MIÚDO NATURAL POR RESÍDUO DE CERÂMICA VERMELHA NA PRODUÇÃO DE ARGAMASSAS
Authors: Furtado Gabriela Becker , Czap Marcela Maier Farias , Bilcati Géssica Katalyne , Paulino Rafaella Salvador
Published: December 2022

Com o propósito de mitigar impactos ambientais gerados tanto pela indústria cerâmica, como pela construção civil, o presente trabalho tem por objetivo analisar a viabilidade técnica da utilização dos resíduos de materiais cerâmicos como material alternativo para a produção de argamassas de revestimento. Dessa forma, a metodologia deste trabalho foi desenvolvida a partir da produção das argamassas de revestimento com substituição do agregado miúdo natural pelo resíduo de cerâmica vermelha (RCV) nas proporções de 0%, 20%, 50% e 100%, avaliando o desempenho no estado fresco e endurecido das argamassas. No estado fresco, as substituições reduziram o espalhamento e a densidade de massa das argamassas. Já no estado endurecido as substituições de 50% e 100%, influenciaram positivamente, tanto na resistência à compressão, quanto na resistência à tração na flexão, aumentando significativamente, em comparação com as argamassas de referência.
Konstruktionsgrammatische Zugänge zur (soziokognitiven) Diskurssemantik
Authors: Bach Matthieu
Published: December 2022

In this paper, I propose an extension of Busse’s cognitive discourse semantics through a usage-based construction grammatical approach. Following Lasch (2015a, 2015b, 2016), I will argue that (i) constructions are discursive per se, and (ii) some constructions can fulfil a textual or discursive function depending on their usage. The theoretical discussion shows that construction grammar is arguably an interesting and fruitful tool of a cognitive discourse semantics, which is empirically explained with examples.
Technological, legal, and sociological summary of biometric technology usage
Authors: Kanich Ondřej , Matejka Ján , Fialová Eva , Kafková Marcela Petrová , Doseděl Tomáš , Drahanský Martin
Published: December 2022

The article presents biometric systems from three different standpoints. Technological standpoint, where the focus is laid on biometric system usage by the general public. Explaining basic terms and difficulties using various biometric characteristics. It also shortly describes how recognition works in several biometric characteristics (fingerprint, face, iris, and signature). After that is the legal standpoint, which is focused mainly on European Union law, where the often-mentioned GDPR is discussed, this basic legal regulation places a significantly higher standard than the previous legislation on the processing of biometric data as a particular category of personal data. Lastly, the article shows a sociological standpoint. In that part, different attitudes towards biometric technologies are discussed within the world population and different groups of the Czech Republic population. In the latest survey done by the authors in 2020 was found that age, and education play a vital role in the knowledge about biometric systems.
CONSELHO NACIONAL DOS DIREITOS HUMANOS E INTERMEDIAÇÃO COMO REPRESENTAÇÃO NOS ESPAÇOS PARTICIPATIVOS
Authors: De Souza Fonseca Mariana
Published: December 2022

O debate sobre a pluralização da representação pretende compreender outras formas de representar, e não somente a tradicional-eleitoral. Esta pesquisa analisa a representação feita pelo próprio Conselho Nacional dos Direitos Humanos, visto que este desempenha função muito particular, qual seja, a realização de missões para averiguar situações de violação de direitos. Essa prerrogativa permite o contato direto do Conselho com as comunidades e envolve organizações para além daquelas que ocupam uma cadeira no plenário do órgão. Nesse caso, o Conselho atua como representante ao mediar a comunidade cujos direitos foram violados e o Estado. O objetivo desta pesquisa centra-se em analisar a intermediação do CNDH sob a definição conceitual de Zaremberg et al. (2017), mobilizando os seus repertórios de atuação, os atores envolvidos e os níveis de conflito com o Estado, bem como diferenciando a atuação reativa e proativa do Conselho.
Evaluation of Cinnamon Supplementation on Insulin Resistance, BMI and Estradiol Levels in Women with Polycystic Ovary Syndrome: A Double-Blinded Randomized Controlled Clinical Trial
Authors: hakak Nasrin , Nazempour Anahita , Saremi AboTaleb , Rezazadeh Shamsali , Momtaz Saeideh
Published: December 2022

Background
Polycystic ovary syndrome (PCOS) is a serious multifactorial disorder. This study intended to assess the effect of cinnamon supplementation on estradiol level, and fasting- and two-hour (2 hpp) insulin and sugar levels in women with PCOS.

Material and Methods
This study was a double-blinded randomized clinical trial (RCT), conducted between January 2019 until December 2020, at Gynecology Clinic Sarem Women’s Hospital in Tehran, Iran. Patients with PCOS, 130 subjects (65 person/ group) were diagnosed using Rotterdam diagnostic criteria. All participants received daily treatment consisting of 1500 mg metformin and 1000 mg cinnamon per day for 12 weeks. An evaluation of serum AMH level was conducted before and after the completion of therapy.

Results
Cinnamon supplementation significantly reduced the estradiol, fasting glucose and 2hpp glucose, fasting insulin and 2 hpp insulin, BMI and weight levels after intervention. The highest reduction was observed in fasting glucose, 2 hpp insulin, and estradiol groups after intervention (P<0.05). There was a significant difference between the means of BMI (P<0.01), fasting sugar (P<0.01), and 2 hpp glucose (P<0.01) before and after intervention.

Conclusion
Cinnamon supplementation, as a safe herbal product, can be prescribed with metformin to improve the symptoms and complications of PCOS.
A Note from the Field in Search of Roland Wayne, Jr. (Not His Real Name): Comment on Social Connectivity
Authors: Johnson Ralph J
Published: December 2022

This brief report article is a retrospective, descriptive, first-person account of following-up on a difficult-to-find client of an HIV/AIDS community-based pre-post intervention and disease prevention Research and Demonstration project in Houston, TX. Through the story about the personal journey of searching for the client, the author experiences an epiphany, especially in light of current events. Specifically, as opposed to social distancing and disconnection, public health disease prevention probably would be better served through leveraging the powerful and positive natural human features of social connectivity and closeness.
Development and Testing of Long-Lasting IRS Products While Revising the WHO Test Protocol
Authors: Skovmand Ole , Ongmayeb Gisele , Kounbobr Dabiré Roch , Georges Meda Benson , Namountougou Moussa , Nguyen Tuan , Dang Duoc , Trang Trung
Published: December 2022

The paper describes the development of a long-lasting product for Intra-domicile residual spray (IRS) and shows it is possible to obtain a residual effect of nearly 2 years. However, to obtain that the methods currently recommended by WHO for laboratory evaluation had to be modified and approached methods closer to the semi-field and field evaluations as applied in later phases of WHO procedures. Surfaces with high pH resulted in short residual effect unless the formulations were mixed with a silicone coating. Screening in huts constructed for the purpose was realised by dividing the wall surfaces in 25 test plots of 0.5 m² where formulations were applied randomly with more repeats the closer to the final formulation. Mud and concrete surface were more challenging than wood surface and stones and these could be dropped for screening. Wall surfaces heated by sun were repellent to non-blood fed mosquitoes, and the test in huts were limited to the mornings. However, blood fed mosquitoes were not repelled. Cone tests on mud-walls are complicated by the uneven structure of the surface and a better way of attaching cones to avoid mortality errors was developed. Formulations that can be applied and last for two mosquito seasons produce big cost savings for IRS programs, since program costs are mostly application costs.
Interviews in Healthcare: A Phenomenological Approach A Qualitative Research Methodology
Authors: Tanwir Farzeen , Moideen Sarah , Habib Raiya
Published: December 2022

Phenomenology is a ritual of Qualitative research methodology. Interviews in healthcare enables researchers to recognise and understand data from lived experiences of the participants by using Phenomenological approach.

The purpose of this article is to review the various face to face in depth interviews conducted using Husserl’s descriptive, Heidegger’s interpretive phenomenology or Hermeneutic phenomenological approach in healthcare. The in-depth interview will help to understand the health issues and ethical issues faced by participants.

Methodology
Four articles were selected based on phenomenological approach.

Article.1 was based on Hermeneutic Phenomenology approach. In this study thirteen women were taken as sample. Sampling was done by snowball method. The women were asked to share their rural maternity experience. Data was analyzed without any influence of the researcher.

Article.2 was based on Transcendental phenomenology. There were 15 students from 4 different cultural background belonging to different health professional programmes like nursing, medicine, pharmacy, dentistry, and physical therapy. Triangulation methods were used and semi structured interviews were conducted, recorded and transcribed. Health professional students shared their lived experience with patients.

Article.3 was based on a study conducted using both Transcendental phenomenology for patients interviews and Hermeneutic phenomenology for healthcare professionals’ interviews.

The semi structured interview of patient was taken to understand and record their lived experience with the medication without any bias or interpretation and data received was bracketed. The healthcare professionals’ interviews were conducted on Hermeneutic strategy regarding the medications they prescribe for life threatening illnesses.

Article 4 was based on Hermeneutic phenomenological approach. There were nine patients selected and in depth semi-structured interviews were conducted. The patients shared their experience of living with a life limiting illness.
Two-Phase Lung Damage Mechanisms For COVID-19 Disease, and Driving Force and Selectivity in Leukecyte Recruitment and Migration
Authors: Wu Jianqing , Zha Ping
Published: December 2022

To understand lung damages caused by COVID-19, we deduced two phases lung damage mechanisms. After the lungs are infected with COVID-19, the affected lung tissue swells and surface properties of pulmonary capillaries change, both contributing to an increased flow resistance of the capillaries. The initial damages are mainly fluid leakage in a limited number of involved alveoli.

The increased vascular resistance results in retaining more white blood cells (“WBCs”) in pulmonary capillaries. Some of the WBCs may get into interstitial spaces. When more and more WBCs are dynamically retained, the vascular resistance of pulmonary capillaries further rises; and thus the overall vascular resistance of the lungs rises and pulmonary pressure rises. The rise in the pulmonary pressure in turn results in elevated capillary pressures. When pulmonary capillary pressures around the alveoli are sufficiently high, the elevated pressure causes interstitial pressures to change from normally negative values to positive values. The positive pressures cause fluid leakage to the alvoeli and thus degrade lung function. Tissue swelling, and occupation of WBCs in interstitial spaces and occupation of alvoelar spaces by leaked water result in reduced deformable and compressible spaces, and thus causes a further rise of the vascular resistance of the lungs. When the pulmonary pressure has reached a critical point as in the second phase, the blood breaks capillary walls and squeezes through interstitial spaces to reach alveolar spaces, resulting in irreversible lung damages. Among potential influencing factors, the available space in the thorax cage, temperature, and humid are expected to have great impacts. The free space in the thorax cage, lung usable capacity, and other organ usable capacities are the major factors that determine the arrival time of last- phase irreversible damage. The mechanisms imply that the top priority for protecting lungs is maintaining pulmonary micro-circulation and preserving organ functions in the entire disease course while controlling viral reproduction should be stressed in the earliest time possible. The mechanisms also explain how leukecytes are “recruited and migrated” into inflamed tissues by dynamic retention.
Practical Suggestions for Win-Win, Win-Lose, Lose-Win, and Lose-Lose Strategies in Mediation or Arbitration
Authors: Buresh Donald L.
Published: December 2022

This essay discusses the practical aspects of mediation and arbitration. The article outlines effective steps to implement win-win, win-lose, lose-win, and lose-lose negotiation strategies. It is posited that with a win-win strategy, the job of a mediator or arbitrator is to find a win-win scenario that is acceptable to both sides. The role of a mediator or arbitrator when the parties are engaging in win-lose, lose-win, and lose-lose strategies is different in that at least one of the parties is not seeking a win for all sides. In particular, when the parties are not involved in a win-win, and court is an option, the parties need to gain as much information about the opposing party as possible to use it to their advantage in court. This is unfortunate but, at times, a necessary result of not participating in a win-win outcome.
Evaluación de hábitos de consumo alimentario y composición corporal en jugadoras de élite universitarias de fútbol sala
Authors: Castillo Martínez Mónica , Jara Zambrano Samuel , Jiménez Alfageme Rubén , González Rodríguez Estela , Hurtado Sánchez Jose Antonio , Ferriz-Valero Alberto , Martínez Sanz Jose Miguel , Sospedra Isabel
Published: December 2022

Introducción: El fútbol sala femenino es un deporte de esfuerzo intermitente. Las deportistas necesitan cumplir con las recomendaciones nutricionales para obtener un rendimiento adecuado. El objetivo del presente estudio es describir la ingesta dietética y la composición corporal de un equipo de élite universitario de fútbol sala.
Metodología: Estudio observacional, descriptivo y transversal realizado en 14 jugadoras semi-profesionales de fútbol sala. Se calculó la composición corporal mediante el modelo de 4 componentes con las ecuaciones de la Sociedad Española de Medicina del Deporte. Para evaluar los hábitos de consumo alimentario se empleó el cuestionario de frecuencia de consumo alimentario del departamento de Salud Pública de la Universidad Miguel Hernández. El análisis estadístico se realizó con el software SPSS. Todas las variables dependientes tenían distribuciones no normales y se calculó el coeficiente de correlación de Spearman (Rho), siendo el nivel de significancia establecido de 0,05 y 0,01.
Resultados: Los valores medios composición corporal observados fueron: 61,69 kg (7,71) kg, talla: 1,64 (0,06) m, porcentaje de masa grasa 12,00 (3,08) % y peso masa muscular 22,03 (3,82) Kg. La clasificación somatotípica de la muestra fue endo-mesomorfo. Respecto a la ingesta dietética. La ingesta dietética se encontraba generalmente por debajo de las recomendaciones de la Guía de la Alimentación Saludable Para Atención Primaria y Colectivos Ciudadanos de Sociedad Española de Nutrición Comunitaria (SENC). Se encontraron correlaciones entre el consumo de algunos alimentos con los valores antropométricos como el consumo de carne y lácteos con un mayor peso de masa muscular (kg).
Conclusiones: El consumo alimentario de las jugadoras está por debajo de las recomendaciones en la mayoría de los grupos alimentarios. Es necesario transmitir a las deportistas la importancia de realizar una planificación nutricional adecuada y específica para sus necesidades para poder mantener unos niveles de rendimiento aceptables así como una composición corporal óptima.
Financiación: Los autores declaran que no han tenido fuente de financiación.
“APESAR DE VOCÊ, AMANHÃ HÁ DE SER OUTRO DIA” : PESQUISA E PRÁTICA DA GEOGRAFIA E DA EDUCAÇÃO EM TEMPOS E ESPAÇOS EXCEPCIONAIS.
Authors: Malheiros Tatiana dos Santos , Da Silva Isabella dos Santos Oliveira , De Lima Vanessa Alessandra dos Santos Vasconcellos Souza
Published: December 2022

Vivemos tempos e espaços difíceis e excepcionais de experienciar no Brasil há um ano. A indignação com o processo em vigência é tamanha que é inviável denominá-lo. Propor-nos-emos a denunciar este massacre e, ademais, anunciar os encaminhamentos de uma política pública de educação, na área da geografia para a formação docente, de geração de encantamento em oposição crítica à necropolítica como modo de operação do atual poder político, jurídico e econômico no país. Qualificaremos o processo de descolonização dos documentos prescritivos de currículo, naquilo que definiremos como ebó epistemológico e curricular – e, de igual modo, a experiência inicial com este documento produzido para atender, em especial, a relação do campo com o contexto pandêmico e o formato remoto emergencial. A epistemologia e a respectiva pedagogia e a geografia feminista afrodiaspórica, por intermédio da aproximação das legislações reguladoras com os documentos de currículo para a educação das relações étnico-raciais e para os direitos humanos, nos induziram nos percursos teórico-conceituais. O engajamento comprometido com a proposta de escrita emancipatória foi amplamente compreendido e se demonstrou um mecanismo potente de produção de conhecimento geográfico-pedagógico em contexto de profunda excepcionalidade. Há indícios de correspondência positiva com a permanência na universidade, independentemente das adversidades.
A alometria ao alcance de todos
Authors: Feltran Filho Antônio
Published: December 2022

A alometria ao alcance de todos
ALIANÇAS ESTRATÉGICAS PARA O DESENVOLVIMENTO SUSTENTÁVEL
Authors: Lira Waleska Silveira , Cândido Gesinaldo Ataíde , Costa Gonçalves Geuda Anazile
Published: December 2022

O artigo trata de avaliar o impacto da implementação da Estratégia de Desenvolvimento Regional Sustentável - DRS proposta pelo Banco do Brasil na Cooperativa das Bordadeiras de Alagoa Nova - COOBAN. Assim, foi realizado um levantamento bibliográfico, complementado de uma coleta de dados junto aos agentes envolvido no processo e que fazem parte da cooperativa. Como resultado pode-se identificar que os impactos da aliança estratégica proporcionada pela DRS do Banco do Brasil, enquanto articuladora, junto a Cooperativa das Bordadeiras de Alagoa Nova são positivos, apresentando problemas em aspectos isolados, que poderão ser superados com ações corretivas por parte das Instituições inseridas no processo. Sugere-se, no entanto, a adoção e implementação de medidas estratégicas como curso de administração financeira e gestão de negócio, oferecidos pelo SEBRAE; Contínuo apoio do Governo do Estado e Prefeitura tanto no que diz respeito à ampliação da participação das artesãs em Feiras de Artesanato como também no monitoramento da gestão da cooperativa para que a mesma torne-se, verdadeiramente, auto-sustentável o que impulsiona o desenvolvimento Regional Sustentável, legitimando o papel de articulador do Banco do Brasil.
O Porto de Aratu no contexto industrial baiano: indicadores de desempenho e os operadores portuários
Authors: Bahia Rios Ricardo
Published: December 2022

Os portos constituem-se em importantes equipamentos responsáveis pela interligação de boa parte da produção local com os mais diversos mercados. O porto de Aratu, atualmente responsável por mais de 60% da movimentação de carga no estado da Bahia, foi projetado estrategicamente para atender as crescentes necessidades de uma área industrializada, caracterizando-o como o primeiro e mais importante complexo portuário industrial do estado voltado para a movimentação de carga, basicamente de químicos, petroquímicos e metalúrgicos beneficiados na Região Metropolitana de Salvador (RMS). Características que o confere diferentes grau de importância na reprodução do capital, contribuindo para a inserção semiperiférica do estado da Bahia no sistema de circulação da economia brasileira e internacional.
How Sinful Is Sin? How Vicious Is Vice?
Authors: Taliaferro Charles , Knuths Emily
Published: December 2022

We defend the guise of the good thesis in a tradition going back to Socrates and Plato, according to which persons act on the basis of what appears to them as good or the least bad or evil act available to them. This seems contrary to moral experience, but we defend the thesis against plausible counter-examples in life as well as fiction. We contend that the thesis makes wrong-doing and vice intelligible, but still wrong, dysfunctional and horrific.
Od mateřského jazyka k českému obřadu
Authors: Kolář Pavel
Published: December 2022

The liturgical practice of the Czechoslovak Church (Cčs) represented a reform of the traditional ritual practices of Western Christianity. The Cčs’ reform proposals are interpreted as being similar to those launched by the contemporary modern liturgical movement in the Roman Catholic Church. The article deals with the principles of the reform set by the first Church council, interprets the Church’s eucharistic rite (the Liturgy of Karel Farský) and compares it with the Tridentine rite, briefly characterizes sacramental rites and occasional services, and presents an outline of the first missal (created by Alois Tuháček). Then, it points to the developments in the Church’s liturgical practices in the decades following the end of WW II until 1971, primarily focusing on the Church’s response to the state’s anti-clerical politics and atheist indoctrination. Finally, the article discusses the Church’s funeral rites, including the ritual provisions for cremation, and introduces the Church’s concept of the liturgical space. Occasionally, it refers to the liturgical diary notes recorded by Pospíšilová and David during their visits Prague parishes of the Church.
Multifunctional role of Nobiletin in cancer chemoprevention
Authors: Malik Durr-E-Shahwar , Attar Rukset , Ozbey Ulku , Romero Mirna Azalea , Yulaevna Ishmuratova Margarita , Purenovic Jelena
Published: December 2022

The diversity of highly bioactive and pharmacologically active natural products which recognize essential biological targets having exquisite specificity, constitutes a massive pharmacological database for discovery of valuable drugs. The rapid accumulation of information has revealed chemopreventive role of nobiletin against wide variety of cancers. Recent efforts are now being expanded and new integrative omics technologies have illuminated continuously upgrading list of molecular mechanisms which underlie carcinogenesis and metastasis. In this mini-review, we explore the progress that has been made in the identification of promising molecular targets of nobiletin.
Silymarin protects the liver from α-naphthylisothiocyanate-induced cholestasis by modulating the expression of genes involved in bile acid homeostasis
Authors: Sohail Imran , Malkani Naila , Tahir Nimra , Khalil Ateeb , Attar Rukset , Mumtaz Sidra
Published: December 2022

Cholestasis is characterized by impaired bile flow which results in inflammation, cirrhosis, and ultimately liver failure. The current study is aimed to evaluate the anti-cholestatic effect of silymarin against α-naphthylisothiocyanate (ANIT) induced cholestasis. Mice were gavaged with various doses of silymarin or ursodeoxycholic acid (UDCA) for 19 days. Then they were challenged with α-naphthylisothiocyanate (ANIT) and after 48 hours the animals were sacrificed to obtain blood and liver sections. Serum levels of bilirubin, aspartate transaminase (AST), alanine transaminase (ALP), and liver histology were analyzed. mRNA expression of selected transporters (Bile salt export pump (BSEP) and sodium taurocholate cotransporting polypeptide (NTCP)) and proteins (farnesoid x receptor (FXR) and Cytochrome P450 Family 7 Subfamily A Member 1 (Cyp7a1)) involved in bile acids biosynthesis, excretion and uptake were also evaluated by quantitative PCR. The results indicated that the serum levels of bilirubin, AST, and ALP were significantly higher in a cholestatic model group as compared to an untreated control group. However, in silymarin groups, the serum level of these parameters is significantly lower than in a cholestatic model group. Liver histology also showed that silymarin prevents ANIT-induced hepatic injury. mRNA expression of FXR, BSEP, and NTCP was downregulated and expression of Cyp7a1 was upregulated in a cholestatic model group as compared to an untreated control group. However, in silymarin treatment groups, the expression of FXR, BSEP and NTCP was upregulated and the expression of Cyp7a1 was downregulated as compared to the cholestatic model group. In conclusion, silymarin could alleviate hepatic injury by modulating the expression of genes involved in bile acid homeostasis.
Exploring the effect of silver nanoparticles on gene expression in colon cancer cell line HCT116
Authors: Alobaid Hussah M. , Daghestani Maha H. , AL-Malahi Nawal M. , Alzahrani Sabah A. , Hassen Lina M. , Metwally Dina M.
Published: December 2022

This study describes a new green method for silver nanoparticles (AgNPs) using Cymbopogon proximus (CP) extract and evaluates their potential anticancer properties in HCT116 cells. Ultraviolet-visible spectroscopy, transmission electron microscopy, dynamic light scattering, and Fourier transform infrared (FTIR) spectroscopy were used to successfully analyze the AgNPs. FTIR spectral analysis revealed the presence of phytochemicals that could be responsible for silver (Ag) ion reduction and AgNP capping. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay demonstrated that treating HCT116 cells with PC-AgNPs for 48 h caused cytotoxic effects, as evidenced by the existence of 20% cell viability. The RT-qPCR study revealed that the expression of two oncogenes (cathepsin B [CTSB] and epithelial cell adhesion molecule [EpCAM]) was significantly reduced in treated cells. The levels of various tumor suppressor genes, including adenomatous polyposis coli (APC), Beclin1 (BECN1), nuclear translocation of β-catenin (CTNNB1), low-density lipoprotein receptor-related protein 6, LRP5, TP53, and TNF, were dramatically reduced in cells treated with CP extract, but this was not the case in cells treated with CP extract. To conclude, CP-AgNPs have demonstrated their ability to induce cytotoxic action and exert antitumorigenic modulatory effects, particularly on the expression of CTSB and EpCAM in colon cancer cells, utilizing AgNPs as an antitumor therapeutic agent for 48 h is not recommended, and reducing the treatment time could be more effective.
English and Chinese existential constructions in contrast: A corpus-based semantic study
Authors: Chen Qiaoyun
Published: December 2022

This article contrasts existential constructions in English and Chinese in terms of semantic variability and dimensions of semantic variation, distribution of Definiteness Effect and existentiality on the basis of corpus instances and their contextual features. Exploratory and confirmatory analyses show that: (1) existential construction in English varies more widely than its Chinese counterpart; (2) existential constructions in English and Chinese differ in covert/overt expression of background information, semantics of the existential verb and the noun phrase (NP) whose existence is asserted as well as an interaction between presence of a coda and NP definiteness. Contextual features such as semantics, number, quantification and modifier of NP and covert/overt expression of background information are found to have a significant effect on the distribution of Definiteness Effect. The survey on existentiality indicates that the concept has multiple manifestations in form. Reasons for these linguistic phenomena are discussed from various perspectives.