bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine learning-mediated Passiflora caerulea callogenesis optimization
Authors: Jafari Marziyeh , Daneshvar Mohammad Hosein
Published: January 2024

Callogenesis is one of the most powerful biotechnological approaches for in vitro secondary metabolite production and indirect organogenesis in Passiflora caerulea. Comprehensive knowledge of callogenesis and optimized protocol can be obtained by the application of a combination of machine learning (ML) and optimization algorithms. In the present investigation, the callogenesis responses (i.e., callogenesis rate and callus fresh weight) of P. caerulea were predicted based on different types and concentrations of plant growth regulators (PGRs) (i.e., 2,4-dichlorophenoxyacetic acid (2,4-D), 6-benzylaminopurine (BAP), 1-naphthaleneacetic acid (NAA), and indole-3-Butyric Acid (IBA)) as well as explant types (i.e., leaf, node, and internode) using multilayer perceptron (MLP). Moreover, the developed models were integrated into the genetic algorithm (GA) to optimize the concentration of PGRs and explant types for maximizing callogenesis responses. Furthermore, sensitivity analysis was conducted to assess the importance of each input variable on the callogenesis responses. The results showed that MLP had high predictive accuracy (R2 > 0.81) in both training and testing sets for modeling all studied parameters. Based on the results of the optimization process, the highest callogenesis rate (100%) would be obtained from the leaf explant cultured in the medium supplemented with 0.52 mg/L IBA plus 0.43 mg/L NAA plus 1.4 mg/L 2,4-D plus 0.2 mg/L BAP. The results of the sensitivity analysis showed the explant-dependent impact of the exogenous application of PGRs on callogenesis. Generally, the results showed that a combination of MLP and GA can display a forward-thinking aid to optimize and predict in vitro culture systems and consequentially cope with several challenges faced currently in Passiflora tissue culture.
Evolutionary game analysis of online game studios and online game companies participating in the virtual economy of online games
Authors: Zhang Gong , Bi Shulei
Published: January 2024

In the context of the new economic development in the post-pandemic era, "play" labor as an important component of digital work has become an inexhaustible driving force for the growth of the digital economy. Previous research has shown that "play" labor, as an emerging business model, can effectively promote the growth of the digital economy. However, there is a relative lack of research on the dynamic evolutionary game between "play" labor suppliers represented by game studios and online gaming companies. In this study, we applied the theoretical approach of dynamic evolutionary game theory to establish a game model depicting the evolution of both parties involved in the virtual economy of online gaming. The aim was to investigate the strategic selection mechanisms and influencing factors for game studios and online gaming companies participating in the virtual economy of online gaming. By analyzing the evolutionary game path, equilibrium points, and factors influencing the evolutionary game outcome, as well as conducting numerical simulation analysis using Matlab software, we found that the incremental gains and costs resulting from the strategic choices of online gaming companies and game studios in engaging in the virtual economy of online gaming affect the evolutionary outcomes. In addition, for the probability ratio of online game studios and online game companies choosing to participate in the virtual economy of online games, whether it is online game studios or online game companies, the larger the initialization ratio, the more likely the evolution result is to develop in a mutually beneficial direction. After an in-depth analysis and discussion of the evolutionary game results, relevant policy recommendations were proposed. We hope to provide a reference for promoting online game companies to strengthen the adequate supervision of online game studios’ participation in the virtual economy of online games and optimize and improve the virtual economic environment.
Feud: Bette and Joan. The representation of ageing in TV series between crisis and wardrobes
Authors: Mascio Antonella
Published: January 2024

The article’s goal is to analyse the ageing-related crisis in the TV series Feud (FX 2017) through the story of two entertainment icons, Bette Davis and Joan Crawford. On-screen, advancing age is narrated as a critical moment for Hollywood of the period. In those years, women after the age of 40 no longer appeared attractive in the movies. The narrative complexity therefore recalls the set of issues related to sexism and misogyny present in the film industry of the time. That is, age challenged the very aura of celebrity, accentuating a rivalry towards the antagonistic actress as towards a younger self. In the television series, Bette Davis and Joan Crawford are played in turn by two other major film personalities: Susan Sarandon and Jessica Lange. On-screen, the two leading ladies express their personalities already by the clothes they wear and the colours they favour, which refer to specific meanings and values. The presence of these two great actresses also defines a further level of interpretation of the text, linked to contemporaneity. The advancing of age, so well highlighted in Feud as a source of crisis, capable of creating a path of lonely struggles in the narrative, becomes off-screen in the current landscape, an opportunity for confrontation and complicity among many actresses and women.
Chiara Ferragni, fashion and digital brand-mom activism
Authors: D’Amelio Maria Elena
Published: January 2024

Chiara Ferragni is a renowned fashion influencer and transnational celebrity. After her hyper-celebrated marriage with Italian rapper Fedez and the creation of the international celebrity brand Ferragnez, Chiara Ferragni is now a full transmedia celebrity, with the docu-film Chiara Ferragni-Unposted (2019) and her participation in the 2023 Sanremo Festival, the main national popular television singing event in Italy. The aim of this article is to analyse Ferragni’s transmedia communication during her Sanremo appearances through her use of fashion as a communicative strategy to raise awareness of the complexity of maternal identity. My argument is that Chiara Ferragni’s maternal celebrity image is an example of what I label digital brand-mom activism: her maternal identity becomes part of the self-branding and is framed in the neo-liberal emphasis of individual choice and ‘have it all’ mentality popularized by Sheryl Sandberg and her Lean In manifesto. The maternal crisis is thus resolved in a generic and superficial exhortation to ‘be yourself’, without questioning the real reasons of the contemporary crisis of motherhood, related to persistent gender stereotypes and structural social impediments for working mothers.
The philosopher’s double cloak: Diderot and Marx on coats, dressing gowns and crisis
Authors: Sassatelli Monica
Published: January 2024

The dismissive stance of thinkers towards fashion is often the starting point for those theories of fashion that are increasingly contributing to overcoming it. However, very rarely do even philosophies of fashion dedicate as much as a single thought to the fashion of philosophers. This neglected aspect of the everyday life of intellectuals, people of the mind, provides a new interpretive key. This article explores two prominent cases of intellectual celebrities, to whom we turn especially in times of crisis, personal or public. Diderot famously underwent a personal crisis as a result of a beautiful new silk dressing gown. Marx, on the other hand, often on the verge of destitution, repeatedly pawned his coat – which poignantly also featured at the beginning of Capital as the epitome of the commodity that does not keep you warm – affecting his capacity or otherwise to go and study at the British Museum. These two cases take us directly to the clothed body of two intellectuals and to the struggle – of mind and body, private and public – that led them, via practice, to theory.
Celebrities dressed like a goddess: Admiration, cultural appropriation and disrespect
Authors: Piancazzo Flavia
Published: January 2024

In September 2020, the Italian edition of Vanity Fair magazine published a series of interviews with Italian women in important professional positions. Each woman interviewed was compared with a female figure that had a paramount role in history or in popular culture. Chiara Ferragni, entrepreneur and influencer who had established herself in the international fashion scene, was depicted as the Madonna with child, painted by Giovan Battista Salvi, also known as Sassoferrato, upsetting readers and social network/internet users. This will be the starting point of our analysis of other cases. At times the media portray or adorn the celebrity as a deity, or as a cult figure, thus mystifying or desecrating the sacred meaning of deities and history; there are dozens of examples of famous people who were portrayed or have made appearances dressed as divinities. The article will aim to offer a comparative analysis by attempting to systematically explain the variants of the social phenomena found in the parallelisms between appropriation and spectacularization of religious clothing.
Framing utopia: Following Warren and Mosley from urban site to textual practice (and back again)
Authors: Walker Stephen
Published: January 2024

This article concerns interconnected works by artists Sophie Warren and Jonathan Mosley, with various collaborators: Planning for Utopia (2007–08), Beyond Utopia (2012) and Utopian Talk-Show (2012–14). It follows their initial proposal to construct an open timber framework tower on a small site near Smithfield Market in London. Discussions with the planning authority there faltered in 2008. In 2012, aspects of the initial project were revisited as a collectively authored, polyphonic book and follow-on instruction-based performance piece. The article will focus on how an initial desire to challenge accepted uses and values of city space was transposed from a real urban situation into the multiple sites of textual practice and how the relationships between representational space, utopia and reality were put into play. Maintaining an explicit conversation with utopic conceits and motifs, these projects test how far an extended critical spatial practice might develop within the specifics of a given urban situation.
COMPARATIVE BIOCHEMICAL CHARACTERISTICS OF FOREST AND GARDEN BILBERRIES AS A RATIONALE FOR USE AS A SOURCE OF FUNCTIONAL INGREDIENTS
Authors: Karimova Natal'ya Yur'yevna , Alekseenko Elena Viktorovna , Tsvetkova Alona Andreyevna , Bakumenko Olesya Evgen'yevna
Published: January 2024

The attention of researchers - developers and manufacturers of food products is deservedly attracted by bilberries due to the rich and various complex of natural components that are beneficial to health. Both wild-growing and cultivated bilberries are involved in the sphere of industrial processing. It is traditionally believed that a berry grown in natural habitats is more environmentally friendly and is not inferior to cultivated varieties in terms of nutritional value. The purpose of the work is to conduct a study of the biochemical composition of berries of forest and garden bilberries to analyze its ability to accumulate food and biologically active compounds. The studies were carried out using modern physicochemical analysis methods (spectrophotometric method, HPLC, atomic absorption method). It has been experimentally shown that garden bilberries accumulate significantly more sugars than forest bilberries The trend for indigestible carbohydrates is the opposite: wild-growing bilberries are characterized by a high content of fiber and pectin with a predominance of the protopectin fraction. According to the content of organic acids, no priorities were identified: forest and garden bilberries were characterized by almost the same content. However, malic acid prevails in wild bilberries, and citric acid prevails in garden bilberries. It has been experimentally proven that wild bilberries are significantly superior to garden bilberries in terms of the content of bioactive polyphenolic compounds, anthocyanins, vitamin C, and carotenoids. In the complex of polyphenolic compounds of forest and garden bilberries, the same representatives of flavonoids (quercetin, rutin, catechin, resveratrol) and their metabolic products, phenolic acids (gallic, cinnamic, chlorogenic, ferulic, lilac), were identified. With the same qualitative composition of anthocyanin compounds, differences in quantitative ratios were revealed: cyanidin-3-galactoside prevails in wild bilberries, and delphinidin-3-galactoside prevails in garden bilberries. As for macronutrients, potassium prevails in both types of bilberries, and more calcium accumulates in garden bilberries. Forest bilberries surpass garden bilberries in terms of micronutrient accumulation. Considering the results of the analysis of the chemical composition it is obvious that the berries of forest and garden bilberries are of exceptional interest to food technologists, since they are a source of biologically active and minor components useful for health, as well as natural dyes and antioxidants. Therefore, the use of bilberries and its processing products in the production of food products will make it possible to endow products with healthy properties and realize functional properties in food technologies.
FEATURES OF ELEMENTS ACCUMULATION IN FRUIT AND BERRY PLANTS CULTIVATED IN THE VICINITY OF ZELENOGORSK CITY, KRASNOYARSK REGION
Authors: Obukhova Anastasiya Valer'yevna , Otmakhov Vladimir Il'ich , Shilova Inessa Vladimirovna , Sarkisov Yuriy Sergeyevich , Yanyuk Alona Yevgen'yevna , Petrova Yelena Vasil'yevna
Published: January 2024

The aim of the study is to identify the peculiarities of the elemental composition of berries (fruits) and leaves of raspberry (Rubus idaeus L.), rowan (Sorbus aucuparia L.), black currant (Ribes nigrum L.), sour cherry (Cerasus vulgaris L.), serviceberry (Amelanchier ovalis Medik.) collected in the vicinity of Zelenogorsk, Krasnoyarsk Region, with an assessment of their potential use as sources of elements, ecological safety of use, as well as patterns of distribution of elements between plants, soil, and the surrounding environment. The elemental composition was analyzed using the method of arc atomic emission spectroscopy with a multi-channel analyzer of emission spectra (DAES with MAES) after ashing. As a result, the presence of 30 elements was determined in the ash of the studied plants, 25 of which belong to trace elements, and 22 are (conditionally) essential. The belongingness of the minimum extremes of content to mostly odd ordinal numbers of elements in the Mendeleev table was established, while the maximum extremes belonged to even ones. It is proposed to represent the revealed regularities in the form of combinations of extrema with the corresponding serial numbers of atoms, which clearly indicates the plant's ability to concentrate certain chemical elements. Based on the degree of accumulation from the soil, which indicates the ability of plants to accumulate elements, the highest indicator for all studied species and their raw materials is K, for all raspberry and blackcurrant raw materials – Ca, for cherry and raspberry leaves with berries (fruits) and separately for cherry fruits – Mg, only for blackcurrant leaves with berries (fruits) – Ti, for blackcurrant leaves with berries (fruits) – Sr and Ag. The study identified only Ti and Ag as having a "strong accumulation" in the biological absorption of elements, while the others were common for vegetation. Raspberry was found to have the highest biogeochemical activity among the studied fruit and berry plants (regardless of the raw material), followed by blackcurrant. It is shown that the raw materials "leaves + berries (fruits)" in all the studied cases contain much more trace elements, in contrast to individual berries (fruits). The study demonstrated the potential use of these plant species as sources of macroelements and trace elements, including essential ones.
ACETONE PRECIPITATION OF PROTEINS FOR DETERMINATION OF THE OF ENZYMES ACTIVITY IN MEDICINAL PLANTS
Authors: Nikonorova Yevgeniya Ramil'yevna , Baleyev Dmitriy Nikolayevich
Published: January 2024

Plant phenolic compounds are widely used in medicine and agriculture. The study of the mechanisms of their biosynthesis and accumulation is a complex task. It is also true for the determination of the activity of the key plant enzymes such as shikimate dehydrogenase. At the same time, the isolation of proteins and enzymes from plant is complicated by the presence of phenolic compounds and pigments. The aim of the research was to evaluate the feasibility of the acetone precipitation of proteins of leaf extracts of plants to determine the activity of shikimate dehydrogenase. The object of the study was the leaves of sea buckthorn (H. rhamnoides) and silky dogwood (C. sericea). The proteins were precipitated from the crude extract with cold (-20 °C) acetone in varying ratio followed by washing three times with acetone and final dissolution in buffer. The activity of shikimate dehydrogenase was determined at pH=10.0 and expressed in ncat per mg of protein. Protein fractions with different activity of shikimate dehydrogenase were isolated from the leaves of sea buckthorn (H. rhamnoides) and silky dogwood (C. sericea). It was shown that the protein fraction with a ratio of 1 : 1.5 of extract : acetone (60% saturation) is most convenient to work with, has a high enzyme activity and does not contain colored impurities. This method of protein isolation and pre-purification is fast, requires a small amount of sample, and suitable for screening studies of the activity of various enzymes in medicinal plants.
Odpowiedzialność karna w dawnych kodyfikacjach norweskiej i polskiej. Próba ujęcia porównawczego
Authors: Darmorost-Sierocińska Elżbieta
Published: January 2024

W pierwszej połowie XX w. pojawiły się w Europie dwie nowoczesne kodyfikacje karne: Nowy kodeks karny norweski z 1902 r. (dalej: Nkk.) oraz polski kodeks karny z 1932 r. (dalej: kk.). Ich nowatorskie rozwiązania stanowiły podwaliny dla rozwoju współczesnego prawa karnego. O kodeksie karnym Norwegii z 1902 r. pisał już w 1916 r. Wacław Makowski, i posiadał on: „ustaloną opinię reformy śmiałej i pod wieloma względami słusznej, a mimo wad – polegających głównie na nie dość ścisłem określaniu istoty poszczególnych «czynów karalnych» – zawiera głównie w części ogólnej szereg pierwszorzędnych zalet". Polski kodeks karny z 1932 r., którego głównym architektem był prof. Juliusz Makarewicz, uznany został za najlepszy w ówczesnej Europie i za jeden z najlepszych w świecie. Należy równie zauważyć, i niektóre rozwiązania kk. zbieżne były z rozwiązaniami Nkk., inne myśl norweską przewyższały. Przystępując do prac nad projektem kk., członkowie Komisji Kodyfikacyjnej zapoznawali się z nowymi ówcześnie inicjatywami ustawodawczymi w zakresie prawa karnego materialnego, uznając za konieczne „dokładne zbadanie stanu kodyfikacji karnej nowoczesnej". Do tych prac zaliczano projekty: kodeksu Rzeszy Niemieckiej, austriacki, szwajcarski oraz kodeks karny Norwegii.
Funkcjonowanie świetlic socjoterapeutycznych w czasie pandemii COVID-19 w Gdańsku, Poznaniu i Katowicach
Authors: Brzezińska Adrianna , Jankowiak Barbara , Soroko Emilia
Published: January 2024

Socio-therapeutic day-care facilities are specifically dedicated to the conduct of socio-therapeutic activities for children and adolescents from high-risk groups and those displaying difficulties in psycho-social functioning. During the pandemic, socio-therapeutic day facilities continued to aid their clients. The aim of this analysis is to describe the operation of socio-therapeutic day care facilities in Gdańsk, Katowice and Poznań. The data collection method for this project is a semi-structured telephone interview, while data is examined via a template analysis. The analyses concerned 30 socio-therapeutic day care facilities in Gdańsk, Katowice and Poznań. The data collected shows that socio-therapeutic day facilities could be an important source of support for the participants and their families. Elements of socio-therapeutic work were retained in contact with the clients to the highest possible degree via online communication. Online meetings enabled discussion of current difficulties, emotional respite and support. Topics discussed included those supporting health-promoting behavior in an epidemiological emergency. Many of the activities went beyond group work and were mainly supportive or crisis intervention. Staff members contacted parents, helped with children’s homework and even donated food parcels.
Pedagogika społeczna wobec globalnych zagrożeń zdrowia
Authors: Dworak Alina
Published: January 2024

Interest in health in educational sciences has a long tradition. Every historical era brings records of hygiene, disease prevention and body care. The classic concept of social pedagogy encourages to take actions aimed at developing permanent hygienic and cultural habits, appropriate attitudes towards health, and individual and collective action (including those related to health). The current century has initiated a “new” educational thinking whose aim is to change individual behavior as well as social activity, in which a health educator should participate. The challenges of the present day require the ability to consider and make the right choices, including health ones, indicating that the modern world urgently needs universal health education, which must be implemented by competent pedagogues.
The balanced superelliptic mapping class groups are generated by three elements
Authors: Omori Genki
Published: January 2024

The balanced superelliptic mapping class group is the normalizer of the transformation group of the balanced superelliptic covering in the mapping class group of the total surface. We prove that the balanced superelliptic mapping class groups with either one marked point, one boundary component, or no marked points and boundary are generated by three elements. To prove this, we also show that its liftable mapping class groups are also generated by three elements. These generating sets are minimal except for several cases of closed surfaces.
Dualism, the Causal Closure of the Physical, and Philip Goff’s Case for Panpsychism
Authors: Sepetyi Dmytro
Published: January 2024

The article discusses Philip Goff’s latest projects of developing panpsychist research program as one that is capable of revealing the place of consciousness in the physical world and accounting for the intrinsic nature of physical reality, while avoiding the problem of the causal closure of the physical that is supposed to be pernicious for psychophysical dualism. The case is made that on the one hand, dualism has pretty good resources to meet the inductive no-gap objection appealing to the causal closure, while on the other hand, insofar as this objection has some force, panpsychism in the forms discussed in Goff’s book Galileo’s Error (Goff, P. 2019. Galileo’s Error: Foundations for a New Science of Consciousness. New York: Pantheon Books) faces nearly the same difficulties and its capability of overcoming these difficulties is problematic. While the hybrid cosmopsychism, as developed in Goff’s later manuscript, circumvents the causal closure problem, it does so at the price of relying on assumptions that are hardly intelligible.
Im/politeness research – what it says on the tin? (Not quite)
Authors: Pizziconi Barbara
Published: January 2024

Several decades of analytical inquiry into linguistic im/politeness have produced a substantial body of research shedding light on its linguistic and social dimensions, but also distinct discursive conventions and terminology. This study turns the spotlight on im/politeness as the term of choice for researchers to think and talk about a rather broad range of social meanings and considers the pros and cons of this preferred denotation. I argue that while the term has undoubtedly scaffolded the development of a coherent field of enquiry, its continued use as a moniker, despite shifting concerns and broadening perspectives, may becloud our views too. The field’s trajectory of development is revisited by likening it to a process of register formation, in which the term im/politeness has accrued differential (and stereotypical) indexicalities for different groups, in a diverse, multicultural community of scholars with different research agendas. Our differential allegiances to a particular taxonomy arguably engender different ways of seeing, and the increasing complexity of the field demands that we continue to interrogate and justify the labels we use.
A pilot study to see the suitable Unani Kit medicines in the patients of drug-induced insomnia
Authors: Bano Humaira , Sidra Sidra , Ali Masroor
Published: January 2024

Insomnia is a common disorder nowadays in the population with high rates of hypertension, diabetes mellitus, obesity, heart attack and stroke that turned the patients to take medications such as Alpha-blockers, Antidepressants, Corticosteroids, hypolipidemic, Anti-inflammatory, weight-reducing agents, and many more medicines prescribes them by the experts. The study aims to fix a suitable kit of medicines from Mujarrabat or Mamulat Matab (Trended Unani prescriptions) as mentioned in Qrabadeen/Biyadh of the Unani classics. In a view of new disease treatment, an observational study has been conducted to see the efficacy of the selected kit of medicines in the drug induced-insomnia patients. A total of 70 participants were registered in general OPD at the Co-location Research Centre J.J. Hospital Byculla Mumbai, they were categorized into three groups with conduction of question-answer session interpreted according to the ‘insomnia severity index’. All included patients have assigned scores as per the answers. Data were analyzed on the version of patients to see a relationship between the medicated and non-medicated patients and found statistically significant at P<0.05. Analysis of per cent distribution of the patients’ consequences and improvement observed in a lay term (Indian-currency unit) as about 20 paise, 40 paise, 60 paise, 75 paise and 80 paise of a rupee. This paisa has considered the percentage of calculation. 71.43% of patients reported the remarkable effects of the given kit medicines. The study concluded that insomnia is significantly high in medicated patients, and a result of Unani kit medicine is also satisfactory it required a clinical trial with full scientific criteria for clear and significant results
Promoting Choosing Wisely Thyroid Function Test Guidelines in a Large Pediatric Hospital System
Authors: Warshawsky Ilka , Lemerman Hanna , Gunkelman Samantha , Mandalapu Rathna , Uli Naveen K. , Patterson Amanda , Gannon David , Engler Laurie , Love April M. , Davidson Joel R. , Baccon Jennifer , Bigham Michael T.
Published: January 2024

BACKGROUND

Free thyroxine (fT4) is often ordered when not indicated. The goal of the current study was to use quality improvement tools to identify and implement an optimal approach to reduce inappropriate fT4 testing throughout a large pediatric hospital system.

METHODS

After reviewing evidence-based guidelines and best practices, a thyroid-stimulating hormone with reflex to fT4 test and an outpatient thyroid order panel with clinical decision support at order entry, along with several rounds of provider education and feedback, were implemented. Outpatient and inpatient order sets and system preference lists were reviewed with subject matter experts and revised when appropriate. Tracking metrics were identified. Automated monthly run charts and statistical process control charts were created using data retrieved from the electronic health record. Charts established baseline data, balancing measure data, monitored the impact of interventions, and identified future interventions.

RESULTS

Over a 44-month period, among nonendocrinology providers, a reduction in fT4 and thyroid-stimulating hormone co-orders from 67% to 15% and an increase in reflex fT4 tests from 0% to 77% was obtained in inpatient and outpatient settings. Direct cost savings as a result of performing 5179 fewer fT4 tests over 3 years was determined to be $45 800.

CONCLUSIONS

After implementation of a reflex fT4 test, a novel order panel with clinical decision support, provider education, and changes to ordering modes, a large and sustainable reduction in fT4 tests that was associated with significant cost savings was achieved among nonendocrinology providers.
Management of Calcified Coronary Lesions
Authors: Al-Shaibi Khaled , Bharadwaj Aditya , Mathur Atul , Jaikishen Ashish , Riley Robert
Published: January 2024

With an aging population, coronary calcification is increasingly encountered in modern day interventional practice. Unfortunately, it is associated with lower procedural success and higher rates of periprocedural complications, such as failure to deliver stents, perforations, dissections, and other major adverse cardiac events. Furthermore, suboptimal stent deployment in the setting of severe calcification is associated with both short- and long-term major adverse cardiac events, including stent thrombosis, MI, in-stent restenosis, and target lesion revascularization. A variety of treatment options for these lesions exist, including specialized balloons, atherectomy, and intravascular lithotripsy. While there is currently no universally accepted algorithm for choosing between these treatment strategies, several different algorithms exist, and the optimization of these treatment regimens will continue to evolve in the coming years. This review aims to provide insights on the different therapeutic modalities and an understanding of the current body of evidence.
Editorial
Authors: Caldas Luzeiro Janio
Published: January 2024

Me complace presentar el dossier temático “Impacto de las violaciones a los derechos humanos e infracciones al Derecho Internacional Humanitario, en el marco del conflicto armado en Colombia en la salud mental de las víctimas en la adultez”, del Programa de Psicología de la Universidad CESMAG. Este dossier que surge como producto del compartir multidisciplinar de docentes e investigadores de la Facultad deCiencias Sociales y Humanas, adscritos a los Programas de Psicología y Derecho de la Universidad CESMAG, refleja de manera concisa y pertinente los temas desarrollados en la “Cátedra Libre Francesco Bellina”, en su primera versión, propuesta por el Programa de Psicología de la Universidad CESMAG.
Single parenting and students’ academic performance
Authors: Hiko Magdaline Agbu Abe , Cakici Es Ayhan , Baysen Engin
Published: January 2024

The need for strength-based research that highlights the way forward on the phenomenon of single parenting and its antecedent effect on students’ academic performance was the motivation for this study. With this study we addressed the direct effect of single parenting on students’ academic performance, while also accounting for the indirect effect of personal achievement motivation and the moderating role of perceived community support. A sample of 379 secondary students from 12 schools in 6 states in Nigeria participated in the survey. The partial least square structural equation model was used for the analysis of the study data through the aid of SmartPLS. We found that single parenting does not have a significant negative effect on students’ academic performance. We also found that personal achievement motivation mediates the relation between single parenting and students’ academic performance; community support was also found to moderate this relationship. When compared to 2-parent homes, single parenting has the greatest effect on students’ academic performance. We support the Self-determination Theory as a contribution to knowledge.
Exploring the Mechanism of Zilongjin in Treating Lung Adenocarcinoma Based on Network Pharmacology Combined with Experimental Verification
Authors: Zhang Kang , Chen Xiaoqun
Published: January 2024

Zilongjin (ZLJ) is a common traditional Chinese medicine for lung adenocarcinoma (LUAD) treatment. However, its mechanisms of action remain to be elucidated. Network pharmacology was used to explore the underlying mechanisms of ZLJ on LUAD treatment. The disease-related targets were determined from the Gene-Cards and DisGeNET databases. Active compounds and targets of ZLJ were obtained from the HIT, TCMSP, and TCMID databases. Then the protein-protein interaction (PPI) network was built by the STRING database to identify core-hub targets of ZLJ in LUAD. Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to analyze the enriched regulatory pathways of targets. Molecular docking analysis was used to evaluate interactions between potential targets and active compounds. Finally, qRT-PCR was used to further verify the results of network pharmacology. A total of 124 LUAD-related targets of ZLJ and 5 active compounds of ZLJ from the relevant databases were screened out. Among these target proteins, JUN, CDH1, PPARG, and FOS were core hub-genes in the PPI network. GO and KEGG pathway enrichment analysis indicated that these targets might regulate the PPAR signaling pathway in LUAD. JUN, PPARG, and FOS levels were upregulated, while CDH1 level was downregulated in LUAD cells. This study discerned that ZLJ may target genes such as JUN, FOS, PPARG, and CDH1 via the PPAR signaling pathway in LUAD, offering foundational insights for further exploration of ZLJ in clinical applications.
Accurate Lagrangian stochastic model on homogeneous turbulence under two shear orientations
Authors: Thamri Lamia , Naffouti Taoufik
Published: January 2024

The paper reports a numerical modelisation of homogeneous and stratified turbulence under vertical and horizontal shear by way of Lagrangian stochastic model (LSM) versus Froude number. Vertical and horizontal shear (θ = 0 and θ = π/2) are adopted. First, a comparison of predictions by LSM with results of direct numerical simulation of Jacobitz (DNSJ) is carried out. Current results obtained by LSM demonstrate the existence of asymptotic equilibrium states for various parameters of the problem particularly for the horizontal shear. Compared to the case of a vertical shear, an excellent agreement between predictions of LSM related to the case of horizontal shear and results of DNSJ is detected for growth rate, ratio kinetic energy to total energy and potential energy to total energy beyond τ = 40. For two shear orientations, results of normalized production and turbulence dissipation are comparable with different approaches for τ ≥ 70. Second, a comparative study of various thermal and dynamic parameters governing the considered problem for horizontal and vertical shear is performed versus Froude number. This study indicates that the LSM can present a significant contribution for numerical modelisation of stratified and homogeneous turbulence especially in the presence of a horizontal shear.
Decision trees applied to injury severity in road accidents with only one victim – focus on vulnerable users
Authors: Pereira Hudson Carrer , Bastos Ana , Seco Alvaro , Antunes Francisco
Published: January 2024

The injury severity resulting from a road accident is usually defined based on the most serious victim, which can involve more than one driver, pedestrian, or passenger. Unlike other works that focus on driver characteristics, the present study developed for urban roads focuses on vulnerable users by limiting the database to accidents with a single victim with more serious injuries. Using the CART algorithm, the selected methodology strives to reduce the effects of data imbalance, incorporating various misclassification costs to improve the ‘accident with death’ prediction (minority class) and evaluating the quality results by association rules. After incorporating a 5:1 misclassification cost, recall increased from 0% to 43.3%. Two predictive ‘death’ decision rules were validated, and the identified factors were alcohol/drug consumption, type of accident, age group and annual average daily traffic for traffic above 70 km/h. Limiting the study to accidents with only one person suffering a more serious injury allowed for the identification of significant variables related to vulnerable users, and that can be considered in support of decision-making to reduce the severity of accidents.
Axiological System of Henryk Elzenberg and Its Impact on the Oeuvre of Zbigniew Herbert
Authors: Kozdęba-Murray Halina
Published: January 2024

Zbigniew Herbert studied philosophy at the Nicolaus Copernicus University in Toruń in the years 1949–1951 and attended seminars conducted by prof. Henryk Elzenberg, whose philosophical stance had a relevant impact on the poet’s oeuvre. This work analyses Stoic heritage present in the works of both the Philosopher and the Poet, as well as presents the axiological system of Elzenberg and its meaning for the attitude of “Mr. Cogito”. Elzenberg, following Seneca, divided values into the utilitarian and perfect ones, where the latter possessed the quality of dignitas (“nobleness”). The perfect values referred to the Greek notion of kalokagathia and they were of primary importance in the creation of high culture that constituted the sphere of human dignity and freedom as opposed to the existential dread, indifference of nature or historical necessity. Herbert shared his Master’s stand on the meaning of culture and the table of values in human life, which is depicted, inter alia, in the poem dedicated to the Professor To Henryk Elzenberg on the Centenary of His Birth. Elzenberg claimed that axiologization the the world equals its substantialization. Finally, the acme of his axiology became natural mysticism and the source of perfect value the “transempirical” reality which Elzenberg used to call “the Undefined”. The Professor was distanced and sceptical towards the world and society. Herbert, on the other hand, remained faithful to the Christian heritage with its confirmation of the world as it is, as well as the everyday human reality, which he treated with sympathy and uderstanding, according to the idea of Christian agape.
Government-Sponsored Mortgage Securitization and Financial Crises
Authors: Passmore Wayne , Sparks Roger
Published: January 2024

This paper analyzes a model of the mortgage market, considering scenarios with and without government-sponsored mortgage securitization. Conventional wisdom says that securitization, by fostering diversification and creating a “safe” asset in the form of mortgage-backed security (MBS), will reduce risk and enhance liquidity, thereby mitigating financial crises. We construct a strategic-game framework to model the interaction between the securitizer and banks. In this framework, the securitizer initiates the process by setting the MBS contract terms, which includes the guaranteed rate and the criterion that qualifies a mortgage for securitization. The bank then selects which qualifying mortgages to exchange for the MBS. Our investigation leads to a key result: government-sponsored securitization, somewhat counterintuitively, is more likely to exacerbate the severity and frequency of financial crises.
Relationship between mateverse cryptocurruncies (meta coins) and sustainability indices
Authors: Say Servet , Dogan Mesut
Published: January 2024

Purpose- The purpose of this study is to determine the relationship between metaverse and sustainability indices. MANA token was used as a metaverse indicator in the study. Dow Jones Sustainability Emerging Markets Index (DJS_EMI), Dow Jones Sustainability World Index (DJS_WI), Dow Jones Sustainability Europe Index (DJS_EI) were used as sustainability indices.
Methodology- In this research, the dynamic relationships between Metaverse and 3 sustainable indices used in the study were analyzed with a time-varying parameter vector autoregressive (TVP-VAR) model. This method is based on the fixed parameter sliding window VAR approach, first developed by Antonakakis and Gabauer (2017) and later updated by Diebold and Yılmaz (2009, 2012, 2014).
Findings- DSJ_EMI variable carries a volatility spread of 24.85% to “DSJ_WI”, 24.81% to “DSJ_EI” and 25.40% to “METAVERSE”. “DSJ_WI” has a 59.68% volatility spread to other variables. The variables “DSJ_EMI” 25.04%, “DSJ_EI” 25.10% and “METAVERSE” 24.69% carry out volatility spread. Finally, while 70.79% of the volatility change in the "METAVERSE" variable is due to itself, a total of 29.21% is due to other variables. The variables “DSJ_EMI” 9.74%, “DSJ_WI” 9.74% and “DSJ_EI” 9.73% perform volatility spread.
Conclusion- Mana (Decentraland Token) is the cryptocurrency used in the virtual reality platform called Decentraland. Metaverse refers to a digital universe called virtual reality, augmented reality and virtual world. Decentraland is a decentralized virtual reality platform that allows users to create, trade and interact with their own digital content.As a result of the analysis, it was determined that MANA, a Metavarse crypto asset, spreads volatility to sustainability indices. In other words, the MANA token spreads volatility to sustainability indices.

Keywords: Metaverse, metaverse cryptocurrincies, meta coins, sustainability ındex, TVP-VAR
JEL Codes: C32, C55, C58
Taxonomic Assessment and Distributional Records of Sphingidae Moths (Lepidoptera: Heterocera) from Nagaland
Authors: Abesh Chakraborty  , Dipanwita Chakraborty  , Sangeeta Biswas  , Anurudha Chakraborty  , Mitrajit Deb
Published: January 2024

An updated checklist of 22 moth species under 14 genera belonging to Sphingidae has been catalogued with an aim to follow the current state of knowledge in moth diversity from the north-eastern state of Nagaland. Although, richly endowed with an array of biodiversity, the state seriously lacks attention regarding faunal status and distributions; ergo, the present work to ascertain the diversity of hawk moths of the state based on records from available literature to fill the void on the path of systematic research.
Quality Assessment Of Andrographis Paniculata (Burm. F.) Wall. Ex Nees WSR To Geographical Region.
Authors: Dr. Mahadev Gundakalle  , Dr. Ajit Lingayat  , Dr. Veena Kupati  , Dr. Divya Khare
Published: January 2024

Kalmegh Andrographispaniculata (Burm. F.) Wall. Ex Nees is one of the main ingredients used in many formulations like Mahavishgarbhataila etc, India`s various part having favourable for Kalamegh plant, but geographical environmental influences the physico-chemical properties like Ash, extractives values and phytoconstituents. All samples passes ayurvedic Pharmacopeial standards but strength showed variations and Belgaum region showed best for Kalamegh . Thus, study revels that medicinal plants collection habitat must be considered.
Flexor Tendon Grafting as Reoperative Procedure for Injuries within Fingers and Thumb
Authors: Miguleva Irina Yu. , Fain Alexey M.
Published: January 2024

Background. The reoperation rate reported in the literature in cases of flexor tendon injuries within the fingers and thumb is about 20%, but the functional results of these reoperations are barely discussed.
The aim of the study was to evaluate the results of flexor tendon grafting performed as a redo procedure in patients who had previously underwent unsuccessful flexor tendon surgery.
Methods. This study reports the outcomes of deep flexor tendon and flexor pollicis longus tendon grafting in 122 fingers of 109 patients depending on two factors — the type of the first failed surgery (tendon suture in 51 fingers vs grafting in 71 fingers) and the type of the medical unit where the failed procedure had been performed (hand surgery department in 76 cases vs general trauma unit in 46 cases).
Results. Our reoperative grafting procedures led to excellent results in 13 fingers of 51 (25.5% [95% CI: 14–40]) after failed tendon suture and in 32 fingers of 71 (45.1% [95% CI: 33–57]) after failed previous grafting, difference is statistically significant (÷2 = 4.888; p = 0.027). Failed surgeries performed at the hand surgery departments were redone with 48.7% [95% CI: 37–60] of excellent results (in 37 fingers of 76) and 14.5% [95% CI: 7–24] of fair results (in 11 fingers of 76). Failed surgeries performed at the general trauma units were redone with 17.4% [95% CI: 8–31] of excellent results (in 8 fingers of 46). This value statistically significantly differed from the hand surgery departments group: ÷2 = 12.054; p = 0.001. For a total, excellent results were obtained in 36.9% [95% CI: 28–46] (in 45 fingers of 122) of reoperative grafting procedures and good results in 34.5% [95% CI: 26–43] (in 42 fingers of 122).
Conclusions. Analysis of the functional results of deep flexor tendon and flexor pollicis longus tendon grafting performed as a reoperative procedure showed that the excellent results with full finger function were achievable in patients who had previously undergone unsuccessful flexor tendon surgery in zone 2. But in general, the rates of motion recovery were significantly lower than in uncomplicated cases, even with a long history of injury. The worst functional results of reoperations were in patients who had previously been unsuccessfully operated in non-specialized medical units.
Türkiye’de ve Dünya’da Bitki Koruma Ürünlerinin Kullanımının Değerlendirilmesi ve Öneriler
Authors: Erdoğan Cem
Published: January 2024

Tarım sektörü, artan gıda talebi, dünya nüfusundaki hızlı artış, verimli tarım arazilerinin giderek azalması, biyolojik çeşitlilik kaybı, çevre kirliliği, iklim değişikliği, kuraklık, bitkisel üretimi sınırlayan zararlı organizmaların sayısının artması, bitki koruma ürünlerine (BKÜ) karşı gelişen direnç, BKÜ’lerin faydalı böcekler üzerine olan olumsuz etkileri, kalıntı, genç nüfusun tarımdan uzaklaşması vb. gibi çok çeşitli yerel ve küresel risklerle karşı karşıya bulunmaktadırlar. Günümüzde tarımsal üretimde yaşanan bu sorunlardan birisi olan tarımsal üretimde verim ve kaliteyi etkileyen hastalık, zararlı ve yabancı otlarla mücadelede en çok tercih edilen yöntem kimyasal mücadele olup, Bitki Koruma Ürünleri (BKÜ) kullanılmaktadır. Türkiye’de 2022 yılında 55.374 ton BKÜ kullanılmıştır. Türkiye’de BKÜ kullanımın incelendiginde, hektara düşen oran 2.26 kg/ha olup, gelişmiş ülkelere göre oldukça düşüktür. Ancak tarımsal üretim faaliyetlerinin yoğun olarak yapıldığı Akdeniz, Ege ve Marmara bölgelerinde BKÜ tüketim miktarı fazladır. Dünyada tarımda BKÜ kullanımı 2021 yılında 2020 yılına göre %4 artışla 3,5 milyon ton aktif madde, toplam pestisit ticareti ise 7,1 milyon ton formüle edilmiş ürün ve toplam değeri 43,2 milyar ABD dolarıdır. Bu çalışma kapsamında, Dünya’da ve Türkiye’de BKÜ kullanımı incelenmiş ve önerilerde bulunulmuştur.