bluuebunny/crossref_metadata_2025 huggingface dataset:
Andrea Jeftanovic, Hablan los hijos. Discursos y estéticas de la perspectiva infantil en la literatura contemporánea
Authors: Pérez Silva María Belén
Published: December 2023

Andrea Jeftanovic, Hablan los hijos. Discursos y estéticas de la perspectiva infantil en la literatura contemporánea

(Santiago de Chile, Editorial Cuarto Propio, 2011, 273 pp. ISBN 978-956-260-579-3)

por María Belén Pérez Silva
Emilia Perassi y Giuliana Calabrese (editado por), Donde no habite el olvido. Herencia y trasmisión del testimonio en Argentina
Authors: Ayram Carlos
Published: December 2023

Emilia Perassi y Giuliana Calabrese (editado por), Donde no habite el olvido. Herencia y trasmisión del testimonio en Argentina

(Milano, Ledizioni, 2017, 345 pp. ISBN 978-886-705-703-0)

 

por Carlos Ayram
Teresa Basile, Infancias. La narrativa argentina de HIJOS
Authors: Cantoni Federico
Published: December 2023

Teresa Basile, Infancias. La narrativa argentina de HIJOS

(Córdoba, Eduvim, 2019, 300 pp. ISBN 978-987-699-569-6)

 

por Federico Cantoni
Fernando Reati y Paula Simón, Filosofía de la incomunicación. Las cartas clandestinas de la Unidad Penitenciaria 1 durante la dictadura (Córdoba, 1976-1979)
Authors: Romero Marchesini Natalia
Published: December 2023

Fernando Reati y Paula Simón, Filosofía de la incomunicación. Las cartas clandestinas de la Unidad Penitenciaria 1 durante la dictadura (Córdoba, 1976-1979)

(Villa María, Eduvim, 382 pp. ISBN 978-987-699-652-5)

 

por Natalia Romero Marchesini
El ’73 en primera persona: respuestas estéticas al horror
Authors: Scarabelli Laura , Carreño Bolívar Rubí , Cantoni Federico , Calì Giuseppe
Published: December 2023

El ’73 en primera persona:  respuestas estéticas al horror (editado por) Rubí Carreño Bolívar, Laura Scarabelli, Federico Cantoni y Giuseppe Calì
I Libri sententiarum potestatis Mediolani (1385-1429): una prima analisi codicologica e diplomatistica
Authors: Invernizzi Ludovica
Published: December 2023

Nel disastroso stato in cui versa la documentazione medievale milanese, la serie di Libri sententiarum potestatis Mediolani che tramanda le sentenze in materia di giustizia criminale dei podestà cittadini tra il 1385 e il 1429 (con lacune) costituisce senza alcun dubbio una fonte fondamentale per diversi motivi. Dopo l’edizione del primo registro che ha ridestato l’interesse verso un materiale a lungo scarsamente considerato nella storiografia, l’analisi della serie considerata sotto un punto di vista tanto diplomatistico, quanto codicologico ha permesso di rilevare le caratteristiche di questa documentazione evidenziando l’influenza delle prassi notarili del periodo, rilevando fattori di continuità e cambiamento, ed aprendo la strada verso possibili future prospettive di ricerca.
Indagini sullo stato patrimoniale di un ospedale prima della riforma amministrativa quattrocentesca: San Vincenzo in Prato e il suo libro di conti (Milano, 1449)
Authors: Epicoco Gaia
Published: December 2023

Prendendo le mosse dall’analisi dell’unico libro di conti tramandatosi dell’ospedale di San Vincenzo in Prato si è ragionato sullo stato patrimoniale dell’ente e sulla gestione amministrativa da questo attuata. Lo studio integrato con altre fonti conservate presso l’Archivio dell’Ospedale Maggiore ha consentito di ricostruire i legami intessuti dall’ente ospedaliero con le famiglie milanesi e, conseguentemente, di osservare come si inserisse nel sistema economico e sociale della città di Milano. Poiché redatto a pochi anni dalla riforma ospedaliera e amministrativa che trasformò il sistema sanitario milanese quattrocentesco il libro di conti si pone inoltre come testimone dello stato economico di uno di quei nove ospedali cittadini che nel 1458 vennero aggregati al nascente Ospedale Maggiore, aprendo cosi alla possibilità di valutare la veridicità delle accuse mosse agli enti ospedalieri che furono tra le motivazioni addotte alla centralizzazione.
Ritorno a Maleo. Forme della parentela e caratteri dell’azione aristocratica nella Lombardia tra X e XI secolo
Authors: Tomei Paolo
Published: December 2023

Scopo dell'articolo è rileggere, a distanza di mezzo secolo dallo studio di Cinzio Violante, il dossier relativo ai ‘da Bariano/da Maleo’. Dall'analisi di queste carte, come noto, ha preso avvio una stagione storiografica di assoluta centralità nel panorama medievistico italiano, volta a definire forme e tempi dei processi di signorilizzazione e territorializzazione. Il mio proposito è assumere un diverso angolo di visuale. Queste stesse testimonianze possono essere la base per una riconsiderazione riguardo alle strutture della parentela, ai caratteri e agli spazi dell'azione politica sul finire del secolo X nel corso dell’XI secolo.
Come (ri)scrivere la storia del Mezzogiorno bassomedievale? Su un progetto di ricerca dedicato alle ‘forme testuali del potere’
Authors: Senatore Francesco
Published: December 2023

L’articolo presenta un progetto di ricerca finanziato dal Ministero italiano (PRIN). Il progetto è basato su un postulato: è impossibile rinnovare la storiografia sul Mezzogiorno d’Italia nel basso Medioevo se non si descrivono e studiano sistematicamente alcune serie archivistiche dell’Archivio di Stato of Napoli, dove è conservata documentazione amministrativa e fiscale relativa all’intero regno. Ci si concentra sulle serie archivistiche, che sono mere collezioni di documenti e registri quattrocenteschi; sulla loro importanza per la storia del Mezzogiorno; sugli obiettivi e sui ‘prodotti’ scientifici del progetto; sull’organizzazione del lavoro. Il coordinatore intende costruire un gruppo di ricerca molto coeso, che comprende i funzionari dell’Archivio di Stato di Napoli, al fine di condividere informazioni e materiali durante il progetto.
ACCURACY OF PATHOLOGIC Q WAVE ON ELECTROCARDIOGRAPHY TO PREDICT NON-VIABLE MYOCARDIUM
Authors: HASHMI KA , MAQBOOL S , KABEER HMA , AKHTAR A , KHATTAK S
Published: December 2023

A prospective study was conducted to determine the diagnostic accuracy of Q wave on ECG in predicting the non-viable myocardium in patients with myocardial infarction, considering SPECT as the gold standard in the Department of Nuclear Cardiology, Ch. Pervaiz Elahi Institute of Cardiology (CPEIC), Multan, from June 2022 to June 2023. A total of 414 patients with myocardial infarction were included in the study. Demographic and clinical data such as age, gender, smoking history, diabetes, and hypertension were collected. Before the SPECT scan, 12 lead ECG was done in all patients to determine the pathologic Q wave. Pathologic Q-wave on ECG was found in 252 (60.87%) and not in 162 (39.13%) patients. Non-viable myocardium on SPECT was found in 231 (55.80%) and not in 183 (44.20%) patients. Pathologic Q-wave was 68.80% sensitive and 49.20% specific, with 63.10% PPV and 55.60% NPV compared to SPECT. This difference was statistically significant (P<0.001). Development of pathologic Q wave on ECG was significantly associated with male gender (P =0.006), hypertension (P=0.008), and smoking (P=0.002). In conclusion, pathologic Q wave on ECG is a reliable tool for predicting non-viable myocardium in CAD patients.
ASSESSMENT OF DIABETES MELLITUS AND RISK OF BREAST CANCER: A PROSPECTIVE STUDY ON THE LOCAL POPULATION
Authors: HASSAN M , AHMED MN , IDREES M , AKRAM I , AIJAZ A , MALIK FR , SADDIQA A
Published: December 2023

Diabetes mellitus (DM), characterized by impaired insulin function or resistance, has gained prominence as a multifaceted health concern. Recent epidemiological studies suggest a potential link between DM and breast cancer risk. This retrospective cohort study, conducted in a Liaquat National Hospital, Karachi from January 2022 to June 2023, aimed to investigate the role of DM in the risk of breast cancer in a population of 120 participants with documented diabetes diagnoses. The participants, with a mean age of 55±8.1 years and fair glycemic control (HbA1c: 7.5%), exhibited a 30% higher likelihood of breast cancer, as indicated by a statistically significant odds ratio of 1.30 (95% CI: 1.05 - 1.60, p < 0.05). Hormonal analyses revealed mean insulin levels of 45 μU/mL, IGF-1 at 150 ng/mL, estrogen at 30 pg/mL, and SHBG at 40 nmol/L in the subset with DM Stratifying by menopausal status and diabetes duration revealed nuanced associations, emphasizing the importance of considering these factors in understanding the DM-breast cancer relationship. Notably, individuals with diabetic nephropathy demonstrated 40% higher odds of breast cancer, remaining significant after adjustments. This study sheds light on the intricate connections between DM and breast cancer risk, emphasizing the need for tailored screening, surveillance, and preventive strategies in clinical management.
Mechanisms of action of tea polyphenols in the modulation of obesity through gut microbiota
Authors: Tang Jiahao
Published: December 2023

Obesity has become an increasingly serious global issue in recent years, leading to a myriad of health concerns for a growing population. Consequently, the quest for rational and safe methods to combat excess body fat has emerged as a mainstream demand among consumers. This paper focuses on tea polyphenols as the primary subject of investigation, employing gut microbiota as a mediator to explore and summarize existing research regarding the anti-obesity effects of tea polyphenols. Current reports suggest that the mechanisms by which tea polyphenols exhibit anti-obesity effects primarily encompass two aspects. Firstly, tea polyphenols can regulate the composition of the gut microbiota, primarily targeting the Firmicutes and Bacteroidetes phyla. This regulation occurs both in their digested state and undigested form, with a greater emphasis on their undigested state. Tea polyphenols primarily function by reducing the abundance of Firmicutes while increasing that of Bacteroidetes, thereby enhancing gut microbiota diversity to exert anti-obesity effects. Secondly, the metabolites of tea polyphenols also play a role in modulating gut microbiota, with phenolic acid compounds being the key metabolites responsible for anti-obesity effects. Compared to the parent tea polyphenols, phenolic acid compounds exhibit higher bioavailability and biological activity.
Comparative study on treatment strategies for insomnia
Authors: Yang Yuzhuo
Published: December 2023

Insomnia is a common sleep disorder that affects the typical quality of life of people. Different treatment strategies are required for insomnia caused by specific factors, such as environment and genetics. Currently, the two main categories of insomnia treatments are cognitive behavioral therapy for insomnia (CBT-I) and pharmacotherapy. However, each treatment has distinctive limitations. CBT-I lacks accessibility and certified facilitators, while pharmacotherapy is more prone to result in negative side effects, addiction, and physiological tolerance. To get over these limitations, it is necessary to come up with new alternative therapies to deal with insomnia effectively. This review is intended to summarize the different causes of insomnia and the latest existing treatments for insomnia. Based on previous studies, this study provides new ideas for future insomnia treatments.
HER2 targeted structure prediction and analysis based on artificial intelligence
Authors: Han Shiya
Published: December 2023

HER2 is a crucial marker in cancer diagnosis and targeted treatment. Accurate structure prediction and analysis of HER2 are vital for understanding its function and designing effective therapies. Our study proposes an end-to-end and artificial intelligence approach that uses deep learning frameworks to predict and analyze HER2s structure. Using top-notch machine learning algorithms, we trained a model on a comprehensive dataset of HER2 sequences and structures. The model showed impressive accuracy in forecasting HER2s tertiary structure, helping identify potential functional areas and critical interaction points. Moreover, our analysis provided new insights into HER2s structural changes and stability, revealing potential regulation mechanisms for targeted therapies. We used advanced bioinformatics tools to validate our predictions and ensure their reliability. This research marks a significant step in understanding HER2s molecular structure and lays a solid groundwork for personalized cancer treatments. By harnessing artificial intelligence, our study offers a promising path for precise medicine and targeted treatments for HER2-overexpressing cancers.
TREM2 mediated A clearance dysfunction in microglia cells by circadian disruption in Alzheimer's disease
Authors: Xu Yangkun
Published: December 2023

Genome-wide association studies (GWAS) have shown that the Trem2 gene is a risk factor associated with the onset of Alzheimer's Disease (AD). The Trem2 gene is highly expressed on the surface membrane of microglia cells in the central neuron system (CNS), which mediates neuron inflammation and the clearance of axons and synapses. As a growing amount of evidence is connecting Circadian disruptions with increased levels of CNS inflammation, this review aims to find a connection between circadian disruption and amyloid-leading Alzheimers disease through Trem2 in Microglia cells. This review summarizes past research independently about the circadian disruption with microglia activation, microglia activation with Trem2, and Trem2-affected MG cells impacting the development of Alzheimers Disease. Further research may focus on specifying the importance of Trem2 microglia cells caused neuron inflammation in the development of Alzheimer's pathology, for whether the early A-beta plaquing is triggered by Trem2 microglia cells, or Trem2 is just contributing but not the causation of AD in its Mild Cognitive impairment (MCI) stage.
The immunotherapy progression of breast cancer
Authors: Yin Yilin
Published: December 2023

Every year, nearly forty thousand people lose their lives to breast cancer. It has become a leading cause of death for women. Researchers have not yet identified the precise cause of cancer. In the past, breast cancer treatment was commonly performed with surgery or chemotherapy. With advances in immunotherapy and technological innovations, a variety of valuable emerging immunotherapies have emerged, including tumor vaccines, adoptive immunotherapies, there is also a class of drugs called immune checkpoint inhibitors. For example, studies have shown that autologous dc vaccines for breast cancer can improve 5-year survival. In addition, the combination of immune cells and cytokines also showed a high effect on killing tumor cells. For example, the combination of lymphokine activated killer cells (LAK) and interleukin-2 (IL-2). However, the side effects should not be ignored. This article discusses recent advances in immunotherapy for breast cancer. Symptoms, etiology, pathogenesis, and prevalence of breast cancer are described separately. It also explains the immunological mechanisms of existing immunotherapeutic modalities and considers the limitations of the current immunotherapy for breast cancer, giving a reference for future development. With the aim of informing future academic research on immunotherapy for breast cancer, the current approaches and vaccines for the treatment are examined in this paper.
The waist injuries and treatment methods of rowers
Authors: You Meiqi
Published: December 2023

Rowing is one of the worlds competitive sports, and it is an extremely energy intensive aerobic sport. This sport requires very strict physical fitness for athletes. Therefore, rowers need to withstand extreme load training and ultra-high intensity endurance training, whether in daily training or in actual competitions. Rowers must possess good physical fitness and functional abilities, as well as flexibility and agility. However, the prolonged physical wear and tear experienced by rowing athletes during training and competition can easily lead to sports injuries. Due to the influence of many factors, emphasis has been placed on rowing physical fitness training. In the specific operation process, it is necessary to closely combine the characteristics of rowing and the actual physical condition of athletes and develop a scientific and reasonable plan for rowing and injury treatment. Therefore, this article first starts from the investigation of physical injuries and types of injuries among different athletes and finds that the proportion of waist injuries is the highest. At the same time, it elaborates on the basic reasons for waist injuries, and finally provides rehabilitation treatment plans, allowing rowing athletes to make more progress and development.
Causes and preventive measures of knee injuries in table tennis players
Authors: Wang Zheng
Published: December 2023

Table tennis, as the national sport of China, is widely practiced throughout the country and takes a leading position in the international arena. With the rapid development of table tennis, many excellent athletes have emerged. Since athletes are under high load in training for a long time, sports injuries are almost unavoidable, especially knee injuries, which have the greatest impact on athletes. Therefore, correctly recognizing the causes of knee injuries and mastering the corresponding preventive measures is an important topic. In this paper, we take the literature method and mathematical statistics method as the main research method, combine the knowledge of sports training science and sports physiology to introduce the parts and degree of knee injuries, analyze the causes of knee injuries according to the characteristics of table tennis, and put forward relevant suggestions, so as to help athletes effectively avoid knee injuries, improve the level of competitiveness, and contribute to the development of Chinas table tennis industry.
Application of tactile sensing in human-computer interaction in robot-assisted surgery and medical fields
Authors: Chen Fengyi
Published: December 2023

Robot-assisted Minimally Invasive Surgery (RMIS) is a revolutionary breakthrough in the field of surgery in 21st-century clinical medicine, and in recent years it has become the standard of care in Western medicine. It makes highly accurate medical operations possible based on the advantages of traditional minimally invasive surgery, such as reducing patient trauma and accelerating post-operative healing. However, the most advanced robotic-assisted surgical systems available on the market, as exemplified by the da Vinci system, are still not equipped with tactile receptors. In recent years, scientists and engineers have come up with different techniques and ideas, including various forms of tactile sensors, to improve the quality of the process. In this paper, the sensor devices that can be used for RMIS are classified into six different types based on their structural characteristics, and typical examples of them are listed. For some of the sensing structures that are only in the theoretical stage, inferences and explanations are given based on references. And the application directions are summarized as tactile diagnosis and operator sensing. Research in the last decade in both areas of sensing technology is summarized and outlined respectively.
Early diagnosis and prognosis of MINOCA by CMR
Authors: Zhang Shuhui
Published: December 2023

Cardiovascular disease is a prevalent health concern in contemporary society. Numerous studies have indicated that certain individuals with myocardial infarction may not obtain symptoms of coronary obstruction in coronary angiography. As a result, there is a growing interest in exploring the evaluation of myocardial infarction with non-obstructive coronary arteries (MINOCA). This article focuses on the application of cardiovascular magnetic resonance (CMR) in the diagnosis and prognosis of MINOCA. In conjunction with the pathological characteristics of MINOCA and the imaging principles underlying CMR technology, this article investigates the role of CMR in the clinical practice of MINOCA. CMR is a valuable technique employed for studying multiple aspects of the heart, including morphology, function, organization and perfusion. By applying diverse parameters and sequences, this non-invasive imaging method emerges as an essential tool for clinical diagnosis and prognosis of various cardiovascular diseases. MINOCA is characterized by insufficient blood supply to the coronary arteries or direct myocardium dysfunction with non-ST-segment elevation and normal or less than 50% stenosis in angiography. The aetiology of MINOCA encompasses a wide range of factors, while the application of CMR shows ability to enhance the diagnostic sensitivity of MINOCA, enabling better identification of the underlying cause of the symptoms and facilitating a personalized prognosis for patients.
Research on the application of electroencephalogram-derived bispectral index in cardiac surgery
Authors: Qi Sheng
Published: December 2023

Monitoring the depth of anesthesia during cardiac surgery is a complex and difficult task. Alongside the conventional standard and advanced monitoring instruments, the EEG bispectral index (BIS) has proven more effective in reducing intraoperative consciousness incidents. Additionally, it offers the benefits of diminishing the requirement for anesthetic drugs and detecting cerebral ischemia. Nevertheless, pertinent evidence indicates that BIS requires improvement in various clinical scenarios. This article provides a comprehensive introduction to the principles of BIS, deliberates on the pros and cons of its clinical application, and explores methods for enhancing its efficacy. BIS fits an optimal number by fitting the mixed information from the EEG. It is widely used in drug application, depth monitoring of anesthesia and evaluation of consciousness state, but low temperature, electronic interference, and systematic error will affect it, and the standardized use and application of new technology will help to enhance its efficacy.
Assessment of the safety of genetically modified foods
Authors: Gu Xinyuan
Published: December 2023

In recent years, with the rapid development of modern science and technology, as people utilize various scientific and technological means to alter the characteristics of organisms, potential hazards to the ecological environment and human health may arise. Due to the extensive application of modern biotechnology, genetically modified (GM) technology has been employed in agricultural production, resulting in genetically modified foods. People are highly concerned about the safety of GM foods. This article uses a literature review to assess the safety of GM foods from the perspectives of the current status of GM animals and plants and potential risks. The results suggest potential toxicity to humans, food allergies, certain environmental hazards, and the possible reduction of biodiversity and gene flow.
Advances in virtual screening techniques for anti-viral drug design: A computational perspective
Authors: Weikang Su
Published: December 2023

With the outbreak of the novel coronavirus, which has been found to mutate almost once a week, future viruses may mutate faster than we think. To deal with the mutation of the virus as soon as possible, the development of new drugs should be accelerated. The traditional drug research and development cycle is long, the cost is high, and the human resource consumption is large. Virtual screening technology has gradually become an indispensable link in the research and development of new drugs because of its high efficiency and low cost. This paper introduces the discovery, structure, symptoms and pathogenesis of 5 viruses (HIV, HBV, HCV, Ebola Virus, Coronavirus), and summarizes the application cases of virtual screening technology in the research and development of new antiviral drugs in recent years, to provide a reference for researchers.
Progress of treating knee osteoarthritis with traditional Chinese medicine
Authors: Zhan Yuxin
Published: December 2023

Knee osteoarthritis is a degenerative diseases-based ailment, the primary cause is lower limb dysfunction in the elderly population, the manifestations of joint pain, swelling, stiffness, deformity, joint friction, dysfunction and other symptoms, adversely impact the patients emotional well-being and quality of life. Chinese herbal medicine, with a long history and as a promising therapeutic, has also been gradually applied to the treatment of osteoarthritis of the knee (KOA). It is based on the conventional Chinese medical theory and its clinical application traditional Chinese medicine (TCM) treatment methods such as using TCM externally, acupuncture, massage, traditional health care, etc., is conducive to achieving significant clinical results. This article reviews the different methods of treating KOA with TCM, and probes into the function and the benefits of combining traditional Western medicine with clinical diagnosis and treatment of KOA in TCM. The results show that shadowboxing, eight trigrams boxing, tendon change classic, the Five Mimic-animal boxing and other important rehabilitation methods in traditional health care not only start from the holistic view of TCM, but also can organically combine breathing, consciousness and movement, and then improve the ability of human motor system through multi-functional exercise. In addition, integrative medicine has positive and effective effect on the treatment of KOA. Different patients should choose the appropriate way to intervene individually. In the future, clinical research efforts should be further strengthened to improve the quality of evidence-based evidence, so as to better guide clinical practice.
Targeted therapies for non-small cell lung cancer based on CRISPR-Cas9 technology
Authors: Zhu Jingqiao
Published: December 2023

Lung cancer is the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the largest subgroup and having very low overall survival rates. This paper will briefly describe the pathogenic mechanism of NSCLC and analyze the pros and cons of several treatments that have been put into the clinic as well as the prospects and potential risks of new gene therapy approaches. Based on these approaches, this article will provide researchable directions for the treatment of NSCLC using CRISPR-Cas9 gene editing technology. The findings of the paper show that targeted drugs rely on the signaling pathway that acts on EGFR to treat cancer, with fewer but still present side effects than conventional therapies. Immunotherapy, which uses a patients own immune recognition to destroy cancer cells, is subject to problems such as an overactive immune response. CRISPR-Cas9 gene editing technology, which starts with the mutated gene that causes cancer and is intended to eradicate the cancer at its source, is underdeveloped, has no proven clinical protocols and carries the risk of incorrect editing. Nowadays, as cancer strikes globally, research on cancer treatment is of great significance in saving lives, ending cancer, individualizing treatment, promoting scientific progress and fostering socio-economic development.
Gut microbiota in systemic lupus erythematosus pathogenesis: an in-depth view of mechanisms inside
Authors: Chen Qifan
Published: December 2023

Systemic lupus erythematosus (SLE), an autoimmune disease that is known to be prototypic, brings systemic influence via abnormal production of autoantibodies targeting nuclear acid, possesses highly sophisticated pathogenesis related to genetic and environmental factors. In current studies, gut microbiota draws increasing attention from researchers as it is considered to trigger local and systemic immune responses. Researchers have detected a wide range of alterations happen in SLE cases and revealed a series of potential mechanisms of how microbiome and metabolites are involved in the development and progression of SLE: translocation of pathobionts out of their normal niches; molecular mimicry inducing cross-activity to initiate autoimmune response; and epitope spreading to widen the target of autoantibodies. Based on the understanding of the microenvironment, treatments aiming at adjusting gut microbiota are proposed, including but not limited to the usage of probiotics or prebiotics, narrow-spectrum antibiotics or phages, dietary management and faecal microbiota transplantation. In this article, research progress showing the connection of gut microbiome with SLE and potential mechanisms as well as suggesting more efficient therapeutic strategies for SLE are reviewed. Although more detailed pathogenesis mechanisms and theories of treatments remain unclear while integration of courses along with advanced techniques are required to reveal the complicated connection shown in clinical trials, research in this territory still shows a promising prospect.
Bone Marrow Cancer caused by JAK2 mutations and related treatments
Authors: Ye Yuyang
Published: December 2023

JAK2 V617F, one of the protein mutations, will cause uncontrolled blood production. The mutation leads to a lot of blood and bone marrow diseases, for instance, myeloproliferative neoplasms, myelofibrosis, leukemia et al. Most of these diseases are deadly. Uncontrolled blood cell production might result in leukemia, myelofibrosis, and bone marrow cancer even worse. However, The development of treatments has not been perfected, so mutations in the JAK2 protein still put patients at risk. This article analyzes the mutation principle of JAK2. Many diseases are caused by mutations. At the same time, experiments have confirmed that JAK2 mutations cross-species and do not only occur in humans. In addition, this article explains the treatment options for diseases caused by JAK2 mutations, such as eBM Treatment and Target Therapy. The research provides the stage that concluded the mutant mechanism and the several treatments for the disease caused by the mutation. Although some of the treatments and therapies are not consummated, the future research orientation could be more focused on the clinical study of target therapies like Parental Proteasome Inhibitors.
Educação digital na infância: reflexões sobre os direitos das crianças na era das conexões
Authors: Paschoal Jaqueline Delgado
Published: December 2023

O convívio com computadores, tablets, smartphones e outros dispositivos eletrônicos é tão natural entre as crianças, de modo que tais recursos acabaram por se tornar uma extensão do próprio corpo. Por meio dessas ferramentas, elas se comunicam, brincam e trocam mensagens, muitas vezes sem a supervisão de um adulto que não se dá conta das armadilhas do universo digital. Em vista disso, este estudo tem como objetivo discutir os riscos e os benefícios das tecnologias da informação e comunicação-TICs, na infância, e demonstrar a importância da parceria entre escola e família na construção de uma relação segura e dialógica das crianças com a cultura digital e seus diferentes artefatos tecnológicos. De caráter bibliográfico, o estudo pretende contribuir para a ampliação do debate acerca da utilização consciente das TICs e de seus benefícios na educação das crianças. Concluiu-se que, embora as prescrições legais criminalizem qualquer tipo de circulação de imagens ou transmissão de conteúdos que ofereçam riscos para a integridade física e moral das crianças, cabe à família e à escola a vigilância virtual e o monitoramento no uso da Internet. Para tanto, é necessário que pais e professores compreendam e se apropriem da linguagem digital, de modo a contribuírem para uma educação digital mais acolhedora na infância.
Autoconservação e anulação do ser infantil em tempos de dominação tecnológica ampliada
Authors: Neuvald Luciane , Luz Adonias Nelson da , Mayer Rui Carlos
Published: December 2023

O artigo objetiva elucidar o vínculo da tecnologia com a sociedade capitalista, com o seu modo de produção e de relação social, bem como tece reflexões acerca da forma como as mídias digitais operam e sobre as pesquisas que mostram como as mídias digitais se têm configurado no cotidiano das crianças e dos jovens. A questão que se coloca é a de que a autoconservação da infância, ou seja, a sua existência e a sua visibilidade nesse contexto, pressupõem a sua anulação, a destituição de sua identidade e de suas culturas. A perspectiva eleita é a da teoria crítica da sociedade, pela qual se evoca a lembrança da promessa emancipatória, ameaçada pelo poder adaptativo da totalidade. Sendo assim, neste artigo não se considera que a infância estaria fadada a desaparecer, tampouco que está ilesa do poder integrador da sociedade altamente racionalizada e organizada, mas se defende a necessidade de uma adequada valorização das culturas infantis.
Educação popular: temas, ideias e sujeitos presentes nas cartas pedagógicas de Carlos Rodrigues Brandão
Authors: Paulo Fernanda dos Santos
Published: December 2023

Este artigo é parte do resultado de uma pesquisa de dois anos, cujo protagonista é o educador popular Carlos Rodrigues Brandão e o objeto de estudos é o seu acervo de correspondências datadas entre 1964 e 1980. Cartas caracterizadas como Cartas Pedagógicas. Esses documentos contribuirão para a continuidade da história da Educação Popular, em especial com temas, ideias e sujeitos pouco ou nada visibilizados no âmbito acadêmico. Nesse texto será pautado a presença da Educação Popular em 94 cartas analisadas. A abordagem do estudo é qualitativa com análise documental a partir de documentos de primeira mão (as correspondências) e reflexões a partir de estudos originários desta pesquisa (Paulo; Dickmann, 2020, 2021; Paulo; Gaio, 2021), assim como uso de entrevistas e-mails recebidos por Brandão. Localizamos 19 sentidos e/ou usos de Educação Popular, sendo que se destacam três: Educação Popular Intersetorial, Educação Popular decolonial e Educação Popular multicultural. Igualmente, identificamos a Educação Popular clandestina em tempos de ditadura civil militar. Assim, as Cartas Pedagógicas de Brandão apresentam encontros entre o passado, o presente e perspectivas de futuro, revelando que a Educação Popular com o sentido crítico-emancipatório é constituída por várias educações populares.
A abordagem Pikler no Brasil e suas contribuições para a prática pedagógica na Educação Infantil
Authors: Borges Débora Fontana , Magalhães Cassiana
Published: December 2023

O objeto deste ensaio teórico é a Abordagem Pikler. Partimos da questão norteadora: como a Abordagem Pikler contribui para a organização da prática pedagógica com as crianças pequenas da Educação Infantil? O objetivo foi compreender o surgimento da abordagem no Brasil e suas contribuições para a prática pedagógica na Educação Infantil. Para tanto, a metodologia partiu das leituras e do aprofundamento nas discussões presentes nos textos de Appell e David (2021); Falk (2021, 2022); Kálló (2021a, 2021b); Kálló e Balog (2021); Nabinger (2018); Rede Pikler Brasil (2022); Soares (2020); Tardos e Szanto (2021); Tardos (2022). Os dados revelaram que a Abordagem Pikler apresenta indicadores importantes para pensarmos a prática pedagógica para e com as crianças da Educação Infantil, desde a organização do espaço, o respeito às especificidades das crianças pequenas, a importância da observação do adulto, bem como a interação das crianças com seus pares e com os adultos.
Manajemen Program Unggulan Pondok Pesantren Queen Al-Falah Kediri dalam Meningkatkan Partisipasi Masyarakat
Authors: El-Islamy Virgin Sabrina , Maryanti Rizka Ayu , Marno Marno , Nur Muhammad Amin
Published: December 2023

Penelitian bertujuan untuk menggali penerapan manajamen progam unggulan pondok pesantren Queen Al-Falah Ploso meliputi perencanaan, pelaksanaan dan evaluasi kurikulum. Dengan menggunakan metode kualitatif deskriptif. Data digali melalui observasi kegiatan pondok pesantren, wawancara dengan guru madin dan guru formal dan dokumentasi tentang program dan kegiatan di pondok pesantren. Berdasarkan hasil dapat disimpulkan sebagai berikut: (1) perencanaan program unggulan sesuai dengan kurikulum meliputi tujuan, program, jadwal kegiatan. Kegiatan santri 24 jam penuh dengan bimbingan Kyai dan para guru, jadwal kegiatan terdiri dari Harian, Mingguan, Semesteran dan Tahunan, (2) Pelaksanaan program unggulan yang diberlakukan di Pondok Pesantren Queen Al-Falah adalah perpaduan antara kurikulum pesantren dengan kurikulum pemerintah, sehingga lulusanya dapat melanjutkan ke jenjang lebih tinggi. Pada Pondok Pesantren Queen Al-Falah membagi jenjang pendidikan menjadi 2 yaitu pendidikan formal (SMP, SMA, SMK) dan pendidikan pesantren atau lebih dikenal dengan Madrasah Islamiyah Salafiyah Riyadlotul Uqul (MISRIU). (3) Evaluasi dilaksanakan dalam jangka pendek, menengah dan panjang, evaluasi yang dilaksanakan akhir semester seperti mengecek kelengkapan ma’na kitab setiap santri, untuk evaluasi dalam kegiatan seperti kegiatan syawir, sekolah formal maupun diniyah.
Manajemen Kurikulum Pembelajaran Muatan Lokal dalam Meningkatkan Mutu Pendidikan di SMP Islam Darul Ulum
Authors: Maryanti Rizka Ayu , El-Islamy Virgin Sabrina , Marno Marno , Nur Muhammad Amin
Published: December 2023

Penelitian ini dilatar belakangi Standar Nasional Pendidikan yang mengacu pada PP RI No. 4 Tahun 2022. Ruang lingkup Standar Nasional Pendidikan meliputi, standar kompetensi kelulusan, standar isi, standar proses, standar penilaian, standar tenaga kependidikan, standar sarana dan prasarana, standar pengelolaan dan standar pembiayaan. Tujuan dari penelitian ini untuk mengetahui proses perencanaan, pengorganisasian, pelaksanaan dan pengevaluasian kurikulum pebelajaran muatan lokal dalam meningkatkan mutu pendidikan di SMP Islam Darul Ulum. Penelitian ini menggunakan metode kualitatif. Adapun metode pengumpulan data dilakukan dengan wawancara mendalam, observasi dan dokumentasi. Hasil dari penelitian ini menunjukkan bahwa: Manajemen kurikulum pembelajaran muatan lokal dalam meningkatkan mutu pendidikan di SMP Islam Darul Ulum dilakukan dengan menggunakan langkah-langkah: perencanaan, pengorganisasian, pelaksanan dan evaluasi. Proses perencanaan meliputi: perkiraan, perumusan tujuan, kebijakan. Sedangkan pengorganisasian meliputi: membuat konsep, menyimpulkan, menetapkan bobot jam pelajaran, pengelolaan spesifikasi. Adapun pelaksanaannya adalah pembuka, inti dan penutup, yang dalam pelaksanaannya yakni di awali dengan salam, kemudian membaca nadhom kitab tauhid, lalu mempelajari kitab (memberikan ma’na) dan penjelasan dan terakhir penutup dengan salam penutup. Sedangkan evaluasinya yakni berupa model evaluasi kuantitatif dan kualitatif serta evaluasi diri sekolah yang merupan model dari evaluasi congruence.
The Use of Storytelling to Develop The Cognitive Aspects of High Order Thinking Skills (HOTS) in Ninth Grade Junior High School
Authors: Azzahra Nuraini , Gaffar Muhammad Andriana
Published: December 2023

This study investigates how storytelling techniques can help students enhance their cognitive aspects of HOTS. The data for this study were gathered through class observations, teacher and student interviews, and field notes with one participant teacher and thirty-three ninth-grade students. According to the previous research, students can improve their cognitive aspects ability through a variety of methods, one of which is storytelling. Storytelling can help students to hone their ability to analyze, evaluate and create well. However, there are certain students who have yet to master this skill. And the results show that storytelling techniques can increase HOTS cognitive abilities when people are more fully involved in storytelling activities and subsequently have talks about analyzing stories together. The teacher asked them to find stories and tell stories in front of the class. This practice is another solution for how to apply storytelling technique to develop students' cognitive aspects of HOTS in schools with limited of facilities and infrastructure. Then it was found that they could master the material and analyze and evaluate the problems in the story through this application. Students stated that the storytelling technique made it easier to understand the learning material and seemed exciting.
Pengembangan Media Pembelajaran Audio Visual Berbasis Podcast pada Mata Pelajaran Sejarah Materi Akar Nasionalisme
Authors: Wahyuni Siwi Dwi , Rufi’i Rufi’i , Arsana I Wayan
Published: December 2023

Penelitian ini dilakukan dengan menggunakan metode Research and Development (R&D) atau penelitian pengembangan yang bertujuan menghasilkan suatu produk. Penelitian ini untuk mengembangkan media pembelajaran audio visual berbasis podcast, dengan menggunakan podcast dapat mempermudah siswa untuk mempelajari materi tanpa terbatas waktu, agar tercapai sebuah pembelajaran yang efektif, efisien dan menarik, terutama pada mata pelajaran sejarah materi akar nasionalisme. Penelitian ini mengacu model Borg and Gall yang dimodifikasi dalam buku Sugiyono, yang terdiri dari sepuluh tahap yaitu potensi dan masalah, pengumpulan data, desain produk, validasi desain, uji coba awal, revisi produk, uji coba pemakaian, revisi produk, produksi masal. Subyek penelitian adalah siswa kelas XI IPS 2 SMA Negeri 1 Sukodadi. Untuk mengetahui kelayakan produk, maka dilakukan uji validasi oleh beberapa ahli, yaitu ahli desain, ahli media dan ahli materi/isi. Data penelitian diperoleh dengan teknik angket, observasi dan dokumentasi. Hasil penilaian berdasarkan angket validasi ahli desain memperoleh skor 94%, validasi ahli media dengan skor 92% dan validasi ahli materi dengan skor 95% tidak perlu revisi. Dengan demikian media pembelajaran audio visual berbasis podcast, sangat layak untuk digunakan dalam proses pembelajaran sejarah khususnya materi akar nasionalisme. Pemilihan materi akar nasionalisme sebagai tema dalam podcast adalah memberi motivasi agar siswa dapat mempelajari materi dengan mudah, sehingga rasa nasionalisme siswa akan tercermin dalam kehidupan di sekolah maupun di lingkungan tempat tinggalnya.
The Development of Project-Based Science Teaching Materials in Building Collaborative Thinking and Acting Skills
Authors: Sudarmono Joko , Rohman Ujang , Prayogo Prayogo
Published: December 2023

Teaching materials are needed to improve the teaching process so that it can make learning easier. The development of project-based learning Science teaching materials aimed to to improve collaborative thinking and action skills at SMK Negeri 1 Sambeng. In this research, the researchers applied the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model reference. This model was structured programmatically with systematic activities in an effort to solve learning problems related to learning media which suit the needs and learning characteristics of students. Based on the results of the development research discussion, the results of the development of project-based science teaching in building collaborative thinking and action skills in class X Vocational Science Science subjects could be utilized and applied. It is hoped that other teaching materials with other subject matter can be developed so that it can improve teaching and learning process.
Hubungan Pengetahuan Agama Islam Generasi Milenial dengan Ketaatan Menjalankan Ibadah Sholat
Authors: Suharyat Yayat
Published: December 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis hubungan Pengetahuan Agama Islam dengan ketaatan melakukan ibadah sholat siswa kelas 8 di SMP Rejis, Kota Bekasi, yang berjumlah 35 orang. Penelitian ini adalah penelitian kuantitatif dengan menggunakan metode survei dan pendekatan korelasional. Teknik pengumpulan data dilakukan dengan menggunakan angket dan hasil belajar siswa. Teknik analisis data dengan menggunakan statistik deskriptif dan statistik inferensial multivariat denggunakan NCSS versi 21. Hasil penelitian menunjukkan adanya hubungan antara pengetahuan agama Islam dengan ketaatan menjalankan ibadah sholat dimana nilai Prob. Level (T.test) sebesar 0,000. Ini artinya bahwa Prob. Level (T-Test) < 0,05, yaitu menolak Ho dan menerima H1, dimana terdapat hubungan antara pengetahuan agama islma dengan ketaatan menjalankan ibadah sholat. Untuk korelasi antara pengetahuan agama Islam dengan ketaatan menjalankan ibadah solat berada pada level sangat tinggi. Variabel dependen yaitu ketaatan menjalankan ibadah sholat dan variabel independent yaitu pengetahuan agama islam memiliki keeratan hubungan dengan nilai correlation sebesar 0,8371 atau 83,71%. Hal ini menunjukkan bahwa prestasi belajar Pendidikan Agama Islam berpengaruh positif dan signifikan terhadap ketaatan beribadah. Dari penelitian ini dapat disimpulkan bahwa pengetahuan agama islam siswa memiliki korelasi terhadap ketaatan dalam menjalankan ibadah sholat pada siswa kelas 8 SMP Rejis, Bekasi.
Analisis Kompetensi Kepribadian Guru Sekolah Dasar
Authors: Ananda Rizki , Nurjanah Siti , Rahma Mega , Ernita Reza
Published: December 2023

Seorang guru yang berkualitas harus memenuhi syarat untuk melaksanakan tugasnya, kualifikasi berarti kemampuan untuk melaksanakan tugas atau bekerja sesuai dengan standar yang telah ditetapkan berdasarkan pengetahuan, keterampilan, sikap dan kepribadian. Guru juga wajib memiliki keterampilan kepribadian sesuai Permendiknas nomor 16 tahun 2007 tentang standar kepribadian guru SD/MI. Menjadi seorang guru berarti menjadikan diri Anda seseorang yang layak dikagumi dan ditiru. Pepatah ini menegaskan bahwa peran guru sangat penting dalam proses pengenalan nilai-nilai, dan transformasi pengetahuan membutuhkan kompetensi yang mapan, sehingga guru layak dikagumi dan dijadikan panutan. Jadi dapat disimpulkan bahwa guru adalah panutan bagi siswanya. Tujuan penulisan artikel ini adalah untuk mengetahui standar kepribadian guru sekolah dasar. Artikel ini ditulis dengan menggunakan metode penelitian literature review. Hasil penulisan artikel ini menunjukkan bahwa standar kepribadian guru diukur dengan beberapa indikator yaitu: (1) stabil, stabil; (2) dewasa, bijaksana; (3) berwibawa, (4) Anda memiliki etos kerja; (5) Adil; (6) bertindak menurut norma agama, hukum dan sosial; (7) berakhlak mulia dan menjadi teladan bagi peserta didik dan masyarakat.
Analisis dan Rekonstruksi Desain Kegiatan Laboratorium Berbasis Diagram Vee pada Materi Pertumbuhan dan Perkembangan
Authors: Qisthi Naufalia , Supriatno Bambang
Published: December 2023

Praktikum dalam pembelajaran Biologi merupakan metode efektif yang bertujuan untuk memberikan kesempatan kepada siswa untuk menguji dan menerapkan teori dengan menggunakan fasilitas laboratorium maupun di luar laboratorium, sehingga membantu mencapai tujuan guru agar semua siswa dapat berprestasi terutama dalam studi Biologi yang sedang mereka tempuh. Namun, Praktikum dalam pembelajaran Biologi merupakan metode efektif yang bertujuan untuk memberikan kesempatan kepada siswa untuk menguji dan menerapkan teori dengan menggunakan fasilitas laboratorium maupun di luar laboratorium, sehingga membantu mencapai tujuan guru agar semua siswa dapat berprestasi terutama dalam studi Biologi yang sedang mereka tempuh. Penelitian ini bertujuan untuk memberikan gambaran mengenai kualitas Desain Kegiatan Laboratorium (DKL) atau Lembar Kerja Peserta Didik (LKPD) pada materi pertumbuhan dan perkembang serta membuat rekonstruksi DKL untuk meningkatkan pemahaman peserta didik.