bluuebunny/crossref_metadata_2025 huggingface dataset:
Laser-clad Inconel 625 coatings on Q245R structure steel: microstructure, wear and corrosion resistance
Authors: Gui Wanyuan , Zhong Cheng , Gu Junyi , Ding Yuhang , Wang Xiaoming , Wu Tao , Liang Yongfeng , Qin Jingyan , Qu Yuhai , Lin Junpin
Published: April 2022

In this work, ultra-low dilution rate Inconel 625 coatings with a thickness of ~534.4 μm were prepared by high-speed laser cladding technique on the Q245R steel. The XRD and TEM results show that the Inconel 625 coatings are mainly composed of the Nb and Mo-enriched laves phase with hexagonal close-packed (HCP) structure and the γ-Ni phase with face-centered-cubic (FCC) structure. The cellular crystal, column crystal, and equiaxed dendritic crystal were observed in the bottom, middle, and top of the Inconel 625 coatings from SEM results, respectively. The wear resistance and corrosion resistance of Q245R steel are significantly improved by high-speed laser cladding Inconel 625 coatings. In addition, the low dilution rate is beneficial for improving the wear and corrosion resistance of high-speed laser cladding Inconel 625 coatings. These findings may provide a method to design the wear and corrosion resistance of coatings on steel's surface.
A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2
Authors: Ilinykh Philipp A. , Periasamy Sivakumar , Huang Kai , Kuzmina Natalia A. , Ramanathan Palaniappan , Meyer Michelle N. , Mire Chad E. , Kuzmin Ivan V. , Bharaj Preeti , Endsley Jessica R. , Chikina Maria , Sealfon Stuart C. , Widen Steven G. , Endsley Mark A. , Bukreyev Alexander
Published: April 2022

Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full spike (S) protein of SARS-CoV-2, its S1 subunit, or the receptor-binding domain, and tested them in hamsters as single-dose intranasal vaccines. The construct bearing full-length S induced high titers of neutralizing antibodies specific to S protein domains critical to the protein functions. Robust memory T cell responses in the lungs were also induced, which represent an additional barrier to infection and should be less sensitive than the antibody responses to mutations present in SARS-CoV-2 variants. Following SARS-CoV-2 challenge, animals were protected from the disease and detectable viral replication. Vaccination prevented induction of gene pathways associated with inflammation. These results indicate advantages of respiratory vaccination against COVID-19 and inform the design of mucosal SARS-CoV-2 vaccines.
CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
Authors: Chen Nan-Peng , Aretz Jonas , Fässler Reinhard
Published: April 2022

The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome segregation. The mechanism that drives FA disassembly at mitotic entry is unknown. Here, we show that the CDK1–cyclin B1 complex phosphorylates the integrin activator kindlin, which results in the recruitment of the cullin 9–FBXL10 ubiquitin ligase complex that mediates kindlin ubiquitination and degradation. This molecular pathway is essential for FA disassembly and cell rounding, as phospho-inhibitory mutations of the CDK1 motif prevent kindlin degradation, FA disassembly and mitotic cell rounding. Conversely, phospho-mimetic mutations promote kindlin degradation in interphase, accelerate mitotic cell rounding and impair mitotic retraction fibre formation. Despite the opposing effects on kindlin stability, both types of mutations cause severe mitotic spindle defects, apoptosis and aneuploidy. Thus, the exquisite regulation of kindlin levels at mitotic entry is essential for cells to progress accurately through mitosis.
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
Authors: Shi Yi-Ming , Hirschmann Merle , Shi Yan-Ni , Ahmed Shabbir , Abebew Desalegne , Tobias Nicholas J. , Grün Peter , Crames Jan J. , Pöschel Laura , Kuttenlochner Wolfgang , Richter Christian , Herrmann Jennifer , Müller Rolf , Thanwisai Aunchalee , Pidot Sacha J. , Stinear Timothy P. , Groll Michael , Kim Yonggyun , Bode Helge B.
Published: April 2022

Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other organisms through natural products. Xenorhabdus and Photorhabdus (XP) living in mutualistic symbiosis with entomopathogenic nematodes generate natural products to mediate bacteria–nematode–insect interactions. However, a lack of systematic analysis of the XP biosynthetic gene clusters (BGCs) has limited the understanding of how natural products affect interactions between the organisms. Here we combine pangenome and sequence similarity networks to analyse BGCs from 45 XP strains that cover all sequenced strains in our collection and represent almost all XP taxonomy. The identified 1,000 BGCs belong to 176 families. The most conserved families are denoted by 11 BGC classes. We homologously (over)express the ubiquitous and unique BGCs and identify compounds featuring unusual architectures. The bioactivity evaluation demonstrates that the prevalent compounds are eukaryotic proteasome inhibitors, virulence factors against insects, metallophores and insect immunosuppressants. These findings explain the functional basis of bacterial natural products in this tripartite relationship.
Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment
Authors: Rhodes Johanna , Abdolrasouli Alireza , Dunne Katie , Sewell Thomas R. , Zhang Yuyi , Ballard Eloise , Brackin Amelie P. , van Rhijn Norman , Chown Harry , Tsitsopoulou Alexandra , Posso Raquel B. , Chotirmall Sanjay H. , McElvaney Noel G. , Murphy Philip G. , Talento Alida Fe , Renwick Julie , Dyer Paul S. , Szekely Adrien , Bowyer Paul , Bromley Michael J. , Johnson Elizabeth M. , Lewis White P. , Warris Adilia , Barton Richard C. , Schelenz Silke , Rogers Thomas R. , Armstrong-James Darius , Fisher Matthew C.
Published: April 2022

Infections caused by the fungal pathogenAspergillus fumigatusare increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about how susceptible patients acquire infection from drug-resistant genotypes in the environment. Here, we present a population genomic analysis of 218A. fumigatusisolates from across the UK and Ireland (comprising 153 clinical isolates from 143 patients and 65 environmental isolates). First, phylogenomic analysis shows strong genetic structuring into two clades (A and B) with little interclade recombination and the majority of environmental azole resistance found within clade A. Second, we show occurrences where azole-resistant isolates of near-identical genotypes were obtained from both environmental and clinical sources, indicating with high confidence the infection of patients with resistant isolates transmitted from the environment. Third, genome-wide scans identified selective sweeps across multiple regions indicating a polygenic basis to the trait in some genetic backgrounds. These signatures of positive selection are seen for loci containing the canonical genes encoding fungicide resistance in the ergosterol biosynthetic pathway, while other regions under selection have no defined function. Lastly, pan-genome analysis identified genes linked to azole resistance and previously unknown resistance mechanisms. Understanding the environmental drivers and genetic basis of evolving fungal drug resistance needs urgent attention, especially in light of increasing numbers of patients with severe viral respiratory tract infections who are susceptible to opportunistic fungal superinfections.
Swarm learning for decentralized artificial intelligence in cancer histopathology
Authors: Saldanha Oliver Lester , Quirke Philip , West Nicholas P. , James Jacqueline A. , Loughrey Maurice B. , Grabsch Heike I. , Salto-Tellez Manuel , Alwers Elizabeth , Cifci Didem , Ghaffari Laleh Narmin , Seibel Tobias , Gray Richard , Hutchins Gordon G. A. , Brenner Hermann , van Treeck Marko , Yuan Tanwei , Brinker Titus J. , Chang-Claude Jenny , Khader Firas , Schuppert Andreas , Luedde Tom , Trautwein Christian , Muti Hannah Sophie , Foersch Sebastian , Hoffmeister Michael , Truhn Daniel , Kather Jakob Nikolas
Published: April 2022

Artificial intelligence (AI) can predict the presence of molecular alterations directly from routine histopathology slides. However, training robust AI systems requires large datasets for which data collection faces practical, ethical and legal obstacles. These obstacles could be overcome with swarm learning (SL), in which partners jointly train AI models while avoiding data transfer and monopolistic data governance. Here, we demonstrate the successful use of SL in large, multicentric datasets of gigapixel histopathology images from over 5,000 patients. We show that AI models trained using SL can predict BRAF mutational status and microsatellite instability directly from hematoxylin and eosin (H&E)-stained pathology slides of colorectal cancer. We trained AI models on three patient cohorts from Northern Ireland, Germany and the United States, and validated the prediction performance in two independent datasets from the United Kingdom. Our data show that SL-trained AI models outperform most locally trained models, and perform on par with models that are trained on the merged datasets. In addition, we show that SL-based AI models are data efficient. In the future, SL can be used to train distributed AI models for any histopathology image analysis task, eliminating the need for data transfer.
Role of Majorana fermions in high-harmonic generation from Kitaev chain
Authors: Pattanayak Adhip , Pujari Sumiran , Dixit Gopal
Published: April 2022

The observation of Majorana fermions as collective excitations in condensed-matter systems is an ongoing quest, and several state-of-the-art experiments have been performed in the last decade. As a potential avenue in this direction, we simulate the high-harmonic spectrum of Kitaev’s superconducting chain model that hosts Majorana edge modes in its topological phase. It is well-known that this system exhibits a topological–trivial superconducting phase transition. We demonstrate that high-harmonic spectroscopy is sensitive to the phase transition in presence of open boundary conditions due to the presence or absence of these edge modes. The population dynamics of the Majorana edge modes are different from the bulk modes, which is the underlying reason for the distinct harmonic profile of both the phases. On the contrary, in presence of periodic boundary conditions with only bulk modes, high-harmonic spectroscopy becomes insensitive to the phase transition with similar harmonic profiles in both phases.
Single center analysis of an advisable control interval for follow-up of patients with PI-RADS category 3 in multiparametric MRI of the prostate
Authors: Boschheidgen M. , Schimmöller L. , Doerfler S. , Al-Monajjed R. , Morawitz J. , Ziayee F. , Mally D. , Quentin M. , Arsov C. , Albers P. , Antoch G. , Ullrich T.
Published: April 2022

To evaluate if follow-up mpMRI scans of patients in PI-RADS category 3 are safe enough to omit or delay prostate biopsy in the future and to determine an optimal control interval. This retrospective single center study includes consecutive PI-RADS category 3 patients with one or more follow-up mpMRI (T2WI, DWI, DCE) and subsequent MRI-targeted and systematic TRUS-guided biopsy between 2012 and 2018. Primary study objective was the verification of a significant PI-RADS category upgrade in follow-up mpMRI in patients with subsequent PCA positive biopsy versus patients with negative biopsy. Further objectives were development of the PI-RADS category and clinical parameters between initial and follow-up mpMRI in the context of histopathologic results and time interval. Eighty-nine patients (median PSA 6.6 ng/ml; PSAD 0.13 ng/ml/ml) were finally included (follow-up period 31 ± 18 months). 19 cases had PCA (median PSA 7.8 ng/ml; PSAD 0.14 ng/ml/ml). 4 cases had csPCA (median PSA 5.4 ng/ml; PSAD 0.13 ng/ml/ml) for which there was a significant PI-RADS upgrade after 12–24 months (mean 3.75; p = 0.01) compared to patients without PCA (mean 2.74). Without PCA the mean PI-RADS category decreased after 25–36 months (mean 2.74; p = 0.02). Clinical parameters did not change significantly except a PSAD increase for PCA patients after 24 months. Patients within PI-RADS category 3 may not need prompt biopsy since those with PCA reliably demonstrate a PI-RADS category upgrade in follow-up mpMRI after 12–24 months. PI-RADS 3 patients with negative biopsy do not benefit from follow-up mpMRI earlier than 24 months.
Dynamics, phylogeny and phyto-stimulating potential of chitinase synthesizing bacterial root endosymbiosiome of North Western Himalayan Brassica rapa L.
Authors: Padder Shahid Ahmad , Rather Rauoof Ahmad , Bhat Sajad Ahmad , Shah M. D. , Baba Tawseef Rehman , Mubarak N. M.
Published: April 2022

The less phytopathogen susceptibility in Himalayan Brassica rapa L. has made it an exceptional crop eluding synthetic pesticide inputs, thereby guarantying economically well-founded and ecologically sustainable agriculture. The relevance of niche microflora of this crop has not been deliberated in this context, as endosymbiosiome is more stable than their rhizosphere counterparts on account of their restricted acquaintance with altering environment; therefore, the present investigation was carried out to study the endophytic microfloral dynamics across the B. rapa germplasm in context to their ability to produce chitinase and to characterize the screened microflora for functional and biochemical comportments in relevance to plant growth stimulation. A total of 200 colonies of bacterial endophytes were isolated from the roots of B. rapa across the J&K UT, comprising 66 locations. After morphological, ARDRA, and sequence analysis, eighty-one isolates were selected for the study, among the isolated microflora Pseudomonas sp. Bacillus sp. dominated. Likewise, class γ-proteobacteria dominated, followed by Firmicutes. The diversity studies have exposed changing fallouts on all the critical diversity indices, and while screening the isolated microflora for chitinase production, twenty-two strains pertaining to different genera produced chitinase. After carbon source supplementation to the chitinase production media, the average chitinase activity was significantly highest in glycerol supplementation. These 22 strains were further studied, and upon screening them for their fungistatic behavior against six fungal species, wide diversity was observed in this context. The antibiotic sensitivity pattern of the isolated strains against chloramphenicol, rifampicin, amikacin, erythromycin, and polymyxin-B showed that the strains were primarily sensitive to chloramphenicol and erythromycin. Among all the strains, only eleven produced indole acetic acid, ten were able to solubilize tricalcium phosphate and eight produced siderophores. The hydrocyanic acid and ammonia production was observed in seven strains each. Thus, the present investigation revealed that these strains could be used as potential plant growth promoters in sustainable agriculture systems besides putative biocontrol agents.
Arctic drainage of Laurentide Ice Sheet meltwater throughout the past 14,700 years
Authors: Süfke Finn , Gutjahr Marcus , Keigwin Lloyd D. , Reilly Brendan , Giosan Liviu , Lippold Jörg
Published: April 2022

During the last deglaciation substantial volumes of meltwater from the decaying Laurentide Ice Sheet were supplied to the Arctic, Gulf of Mexico and North Atlantic along different drainage routes, sometimes as catastrophic flood events. These events are suggested to have impacted global climate, for example initiating the Younger Dryas cold period. Here we analyze the authigenic Pb isotopic composition of sediments in front of the Arctic Mackenzie Delta, a sensitive tracer for elevated freshwater runoff of the retreating Laurentide Ice Sheet. Our data reveal continuous meltwater supply to the Arctic along the Mackenzie River since the onset of the Bølling–Allerød. The strongest Lake Agassiz outflow event is observed at the end of the Bølling–Allerød close to the onset of the Younger Dryas. In context of deglacial North American runoff records from the southern and eastern outlets, our findings provide a detailed reconstruction of the deglacial drainage chronology of the disintegrating Laurentide Ice Sheet.
Biomarker modeling of Alzheimer’s disease using PET-based Braak staging
Authors: Therriault Joseph , Pascoal Tharick A. , Lussier Firoza Z. , Tissot Cécile , Chamoun Mira , Bezgin Gleb , Servaes Stijn , Benedet Andrea L. , Ashton Nicholas J. , Karikari Thomas K. , Lantero-Rodriguez Juan , Kunach Peter , Wang Yi-Ting , Fernandez-Arias Jaime , Massarweh Gassan , Vitali Paolo , Soucy Jean-Paul , Saha-Chaudhuri Paramita , Blennow Kaj , Zetterberg Henrik , Gauthier Serge , Rosa-Neto Pedro
Published: April 2022

Gold-standard diagnosis of Alzheimer’s disease (AD) relies on histopathological staging systems. Using the topographical information from [18F]MK6240 tau positron-emission tomography (PET), we applied the Braak tau staging system to 324 living individuals. We used PET-based Braak stage to model the trajectories of amyloid-β, phosphorylated tau (pTau) in cerebrospinal fluid (pTau181, pTau217, pTau231 and pTau235) and plasma (pTau181 and pTau231), neurodegeneration and cognitive symptoms. We identified nonlinear AD biomarker trajectories corresponding to the spatial extent of tau-PET, with modest biomarker changes detectable by Braak stage II and significant changes occurring at stages III–IV, followed by plateaus. Early Braak stages were associated with isolated memory impairment, whereas Braak stages V–VI were incompatible with normal cognition. In 159 individuals with follow-up tau-PET, progression beyond stage III took place uniquely in the presence of amyloid-β positivity. Our findings support PET-based Braak staging as a framework to model the natural history of AD and monitor AD severity in living humans.
Spatial structure impacts adaptive therapy by shaping intra-tumoral competition
Authors: Strobl Maximilian A. R. , Gallaher Jill , West Jeffrey , Robertson-Tessi Mark , Maini Philip K. , Anderson Alexander R. A.
Published: April 2022

Background

Adaptive therapy aims to tackle cancer drug resistance by leveraging resource competition between drug-sensitive and resistant cells. Here, we present a theoretical study of intra-tumoral competition during adaptive therapy, to investigate under which circumstances it will be superior to aggressive treatment.

Methods

We develop and analyse a simple, 2-D, on-lattice, agent-based tumour model in which cells are classified as fully drug-sensitive or resistant. Subsequently, we compare this model to its corresponding non-spatial ordinary differential equation model, and fit it to longitudinal prostate-specific antigen data from 65 prostate cancer patients undergoing intermittent androgen deprivation therapy following biochemical recurrence.

Results

Leveraging the individual-based nature of our model, we explicitly demonstrate competitive suppression of resistance during adaptive therapy, and examine how different factors, such as the initial resistance fraction or resistance costs, alter competition. This not only corroborates our theoretical understanding of adaptive therapy, but also reveals that competition of resistant cells with each other may play a more important role in adaptive therapy in solid tumours than was previously thought. To conclude, we present two case studies, which demonstrate the implications of our work for: (i) mathematical modelling of adaptive therapy, and (ii) the intra-tumoral dynamics in prostate cancer patients during intermittent androgen deprivation treatment, a precursor of adaptive therapy.

Conclusion

Our work shows that the tumour’s spatial architecture is an important factor in adaptive therapy and provides insights into how adaptive therapy leverages both inter- and intra-specific competition to control resistance.
Copper-mediated etherification via aryl radicals generated from triplet states
Authors: Zhang Li , Israel Eva M. , Yan Jiyao , Ritter Tobias
Published: April 2022

Carbon–heteroatom (C–X) cross-coupling is a common method for bond-forming reactions in chemistry but the more electronegative the heteroatom X is, the more challenging the bond formation becomes. Although reductive elimination from Cu(III) intermediates to form C–X bonds is generally a facile reaction, oxidative addition of Cu(I) into the carbon–(pseudo)halide bond of aryl (pseudo)halides is energetically challenging. Therefore, cross-coupling reactions of aryl halides with a variety of nucleophiles is currently out of reach for methods based on copper. Here we present a strategy to bypass the high-barrier oxidative addition step to aryl halides by the generation of aryl radicals from triplet states. Photoinduced energy transfer to, or direct excitation of, aryl halides even enables the use of aryl chlorides as electrophilic coupling partners. This strategy allows for the use of alcohols, amines and fluoride as nucleophiles and expands the scope of copper-mediated cross-coupling chemistry.
Future Directions in Biomedical Imaging Using Supramolecular Chemistry
Authors: Gunnlaugsson Thorfinnur , McClenaghan Nathan D. , Pal Robert , Doyle Robert P. , Zubieta Jon , Faulkner Stephen , Bonnet Célia S. , Farrer Nicola J. , Giordani Silvia , Martynenko Irina V. , Purcell-Milton Finn , Gun'ko Yurii K.
Published: April 2022

In summing up, we have asked each of our authors to provide their view of what the future holds in this exciting and rapidly developing field.
Magnetic nanocluster-mediated photothermal effect and macrophage modulation for synergistic photothermal immunotherapy of cancer
Authors: Ren Xiaoqing , Yuan Wanqiong , Ma Jing , Wang Ping , Sun Suhui , Wang Shumin , Zhao Rongsheng , Liang Xiaolong
Published: April 2022

Magnetic nanoclusters (MNCs) promote tumor regression and inhibit cancer metastasis through an intrinsic photothermal effect synergized with induced macrophage repolarization and T cell modulation.
Characterization, sources, and atmospheric transformation of a few key short-lived climate pollutants (SLCPs) at a rural super-site in the Indo-Gangetic Plain (IGP) of India
Authors: Prakash Jai , Mishra Harsh Raj , Mitra Kalyan , Chandra Bhilok , Hallquist Mattias , Habib Gazala , Tiwari Geetam , Pettersson Jan B. C. , Boman Johan , Pleijel Håkan , Pathak Ravi Kant
Published: April 2022

The observed high BC and BrC levels were linked to local biomass burning, where BrC was mostly primary in nature and co-emitted with BC. BrC transformation during the daytime was potentially associated with photochemical processes.
The first progress of plasma-based transition metal dichalcogenide synthesis: a stable 1T phase and promising applications
Authors: Kim Hyeong-U. , Seok Hyunho , Kang Woo Seok , Kim Taesung
Published: April 2022

An insight into the synthesis of 2-dimensional transition metal dichalcogenides (TMDs) and classification of the phases with various synthesis methods. Herein, the 1T phase of TMDs is reviewed with a unique synthetic method with cold plasma (plasma enhanced CVD).
Evaluation of laser direct infrared imaging for rapid analysis of pharmaceutical tablets
Authors: Carruthers Hannah , Clark Don , Clarke Fiona C. , Faulds Karen , Graham Duncan
Published: April 2022

Chemical imaging is an important tool for characterising the distribution of components within pharmaceutical tablets. LDIR imaging has shown to be a promising technique for providing high-definition component distribution maps at an order of magnitude faster than traditional methods.
Enabling alcohol as a hydrogen carrier using metal–organic framework-stabilized Ir–Sc bifunctional catalytic sites
Authors: Wang Jing , Liu Huichong , Chen Jiawei , Cao Lingyun , Wang Cheng
Published: April 2022

MOF-stabilized Ir–Sc bifunctional catalytic sites couple alcohol dehydrogenation and acetal formation to overcome the thermodynamic limit of hydrogen production from alcohol.
Lithium–nitrogen–hydrogen systems for ammonia synthesis: exploring a more efficient pathway using lithium nitride–hydride
Authors: Ravi Manoj , Makepeace Joshua W.
Published: April 2022

Lithium nitride–hydride offers advantages in stability, preparation method and activity for ammonia synthesis in a chemical looping regime.
A six-plex switchable DNA origami cipher disk for tandem-in-time cryptography
Authors: Dong Yuxiang , Jin Zehui , Zhang Xue , Tang Yuanyuan , Tian Ye , Zhu Jun-Jie , Min Qianhao
Published: April 2022

We devise a DNA origami cipher disk allowing random, continuous and reversible switchover between six distinguishable patterns, by which tandem-in-time cryptography was proposed for secure and accurate information transfer.
Tetraphenylethylene-embedded [15]paracyclophanes: AIEgen and macrocycle merged novel supramolecular hosts used for sensing Ni2+ ions
Authors: Wang Kaiya , Huang Xingyi , Mohan Makesh , Zhang Kaituo , Zuo Minzan , Shen Yuhong , Zhao Yue , Niemeyer Jochen , Hu Xiao-Yu
Published: April 2022

Two novel macrocycles with interesting photophysical properties were synthesized by embedding TPE AIEgens into the [15]PCP scaffold at meso-positions.
Pt modulation of NbSe2 for enhanced activity and stability: a new Pt3Nb2Se8 compound for highly-efficient alkaline hydrogen evolution
Authors: Luo Mengjia , Wu Tong , Xu Shumao , Wang Ruiqi , Huang Fuqiang
Published: April 2022

A new compound Pt3Nb2Se8 was designed by Pt modulation of NbSe2 with enhanced catalytic activity and stability for the HER. Pt3Nb2Se8 exhibits an overpotential of 44 mV at 10 mA cm−2 and a Tafel slope of 38.4 mV dec−1, superior to those of commercial Pt/C.
Metal–organic framework structures of fused hexagonal motifs with cuprophilic interactions of a triangular Cu(i)3(pyrazolate-benzoate) metallo-linker
Authors: Menzel Saskia , Heinen Tobias , Boldog Ishtvan , Beglau Thi Hai Yen , Xing Shanghua , Spieß Alex , Woschko Dennis , Janiak Christoph
Published: April 2022

The hexagonal motifs dictated by the {Cu3} pyrazolate triangular units are joined together by the additional connectivity of the various alternating zinc (oxo)carboxylate units to form 2D/3D open structures (* relates the same example-structure).
Synthesis, structure and reactivity with phosphines of Hg(ii)ortho-cyano-aminothiophenolate complexes formedviaC–S bond cleavage and dehydrogenation of 2-aminobenzothiazoles
Authors: Al-Jibori Subhi A. , Irzoqi Ahmed A. , Al-Janabi Ahmed S. M. , Al-Nassiry Amenah I. A. , Basak-Modi Sucharita , Ghosh Shishir , Wagner Christoph , Hogarth Graeme
Published: April 2022

Hg(ii)ortho-cyano-aminothiophenolate (ocap) complexes [Hg{SC6H3XN(CN)}]n (X = H, Me, Cl, Br, NO2) have been prepared from dehydrogenation and C–S bond cleavage of 2-aminobenzothiazoles.
A three-dimensional crosslinked nano-structure via in situ growth of carbon nanotube/cobalt sulfide composites on porous carbon nanofibers for enhanced sodium storage
Authors: Shi Qian , Chen Kaiyun , Yu Zhonghai , Dai Zhiyong , Wang Jingxiao , Chen Yuanliang , Ma Lan , Han Rui , Cao Kun , Tian Fanghua , Yang Sen , Zhang Yin
Published: April 2022

Improved sodium-ion storage performance by in situ growth of carbon nanotubes and cobalt sulfide nanoparticles on the surface of carbon nanofibers.
A tripodal wheeled mobile robot driven by a liquid metal motor
Authors: Xue Rui , Guo Wenshang , Tao Ye , Ren Yukun
Published: April 2022

An 8-shaped tripodal wheeled mobile robot utilizing liquid metal motors as the core driving part is proposed herein. This robot can achieve three types of driving functions on a two-dimensional plane via wireless control.
Synthesis of highly stable double-coated Zn-doped cesium lead bromide nanocrystals for indium ion detection in water
Authors: Ray Smaranika , Mohapatra Ashutosh , Bhaumik Saikat
Published: April 2022

Double-coated CsPbBr3@SiO2@PVP perovskite NCs exhibit higher luminous intensity and better structural stability than those without PVP, enabling indium ion detection in water.
An ultrastretchable, high-performance, and crosstalk-free proximity and pressure bimodal sensor based on ionic hydrogel fibers for human-machine interfaces
Authors: Ding Haojun , Wu Zixuan , Wang Hao , Zhou Zijing , Wei Yaoming , Tao Kai , Xie Xi , Wu Jin
Published: April 2022

An ultrastretchable hydrogel fiber-based proximity/pressure bimodal sensor with high sensitivity, resilience and low detection limit, and capability for real-time monitoring of physiological signals and human-machine interfaces is fabricated.
Hydrogel- and organohydrogel-based stretchable, ultrasensitive, transparent, room-temperature and real-time NO2 sensors and the mechanism
Authors: Wei Yaoming , Wang Hao , Ding Qiongling , Wu Zixuan , Zhang He , Tao Kai , Xie Xi , Wu Jin
Published: April 2022

Highly stretchable, transparent, ultrasensitive, selective and room-temperature NO2 sensors are created by using ion-conductive hydrogels/organohydrogels. The electrodes play a key role in sensing performances and NO2 tend to react at the cathode.
Mechanically and electrically biocompatible hydrogel ionotronic fibers for fabricating structurally stable implants and enabling noncontact physioelectrical modulation
Authors: Chen Zhihao , Zhang Taiwei , Chen Chun-Teh , Yang Shuo , Lv Zhuochen , Cao Leitao , Ren Jing , Shao Zhengzhong , Jiang Li-bo , Ling Shengjie
Published: April 2022

An electrically and mechanically biocompatible alginate hydrogel ionotronic fiber with a highly-oriented nanofibril and molecular network was constructed, and it is promising for the application in electrically-conductive implantable devices.
Synergistic improvement of sensing performance in ferroelectric transistor gas sensors using remnant polarization
Authors: Shin Wonjun , Yim Jiyong , Bae Jong-Ho , Lee Jung-Kyu , Hong Seongbin , Kim Jaehyeon , Jeong Yujeong , Kwon Dongseok , Koo Ryun-Han , Jung Gyuweon , Han Changhyeon , Kim Jeonghan , Park Byung-Gook , Kwon Daewoong , Lee Jong-Ho
Published: April 2022

Polarization, and the opportunities it affords, are exploited in NO2 gas detection using HZO as the ferroelectric layer to control the gas-sensing performance of the ferroelectric TFT gas sensors.
Bulk-like emission in the visible spectrum of colloidal LiYF4:Pr nanocrystals downsized to 10 nm
Authors: Komban Rajesh , Spelthann Simon , Steinke Michael , Ristau Detlev , Ruehl Axel , Gimmler Christoph , Weller Horst
Published: April 2022

Herein, highly stable colloidal LiYF4:Pr3+ nanocrystals are presented for the first time. Through extensive comparison of their spectroscopic behavior with bulk crystals an unusual intense bulk like emission in the visible spectrum was observed.
Facile and efficient photocatalyst for degradation of chlortetracycline promoted by H2O2
Authors: Bai Yuting , Han Meirong , Li Xiangrui , Feng Sisi , Lu Liping , Ma Shengqian
Published: April 2022

A ternary Ce-MOF/GO/Fe3O4 composite was prepared as a recyclable photocatalyst for photocatalytic degradation of chlortetracycline and showed excellent stability.
Efficient red organic LEDs via the combination of an exciplex host and micro-cavity
Authors: Li Jiao-Yang , Wang Ya-Kun , Zhou Jun-Gui , He Wei , Dong Xiao-Hao , Zhang Chuan , Shi Xiao-Bo , Lia Liang-Sheng , Fung Man-Keung
Published: April 2022

We report a current efficiency of 99.7 cd A−1 for a red OLED with an electroluminescence (EL) peak at 604 nm (full width at half maximum of 32 nm).
Synergistic end-capped engineering on non-fused thiophene ring-based acceptors to enhance the photovoltaic properties of organic solar cells
Authors: Rashid Ehsan Ullah , Iqbal Javed , Khan Muhammad Imran , El-Badry Yaser A. , Ayub Khurshid , Khera Rasheed Ahmad
Published: April 2022

The computational analysis revealed the bathochromic shift of the UV-visible absorption, reduced band gap have and increased LHE of all developed molecules as compared to the reference molecule. VOC was calculated by making their complex of molecules with PTB7-Th donor.
Fabrication and characterization of impact-resistant core-spun yarn fabrics with a hydroxylated fullerene-strengthened shear thickening fluid
Authors: Cai Wenhua , Zhang Rong , Wang Xuechen , Zhang Xingxiang
Published: April 2022

Shear thickening fluid (STF) is investigated to strength soft armor; however, its impact resistance still does not meet practical needs.
Effects of liquid crystal polymer (LCP) on the structure and performance of PEEK/CF composites
Authors: Song Meiyun , Wang Xiaoqing , Du Ran , Zhou Zhen , Li Xiaomeng , Li Guoping , Luo Yunjun
Published: April 2022

Here a liquid crystal polymer (LCP) was introduced into a PEEK/CF system as a new solution to simultaneously promote processing and mechanical performance of PEEK/CF and other polymer-based composites.
Curing behavior of sodium carboxymethyl cellulose/epoxy/MWCNT nanocomposites
Authors: Zhang Jin , Tan Lu , Dong Hongxing , Qu Wenshan , Zhao Jianguo
Published: April 2022

Kinetics calculated values and dynamic thermomechanical properties of CMC/CNTs/E44 systems.
Sulfonic acid functionalized dendrimer-grafted cellulose as a solid acid catalyst for the high-yield and green production of 5-hydroxymethylfurfural
Authors: Niakan Mahsa , Masteri-Farahani Majid , Karimi Sabah , Shekaari Hemayat
Published: April 2022

An efficient heterogeneous acid catalyst was prepared via the growth of a thiol-functionalized third-generation dendrimer on the surface of cellulose employing thiol–ene click chemistry, followed by the formation of sulfonic acid groups via the oxidation of thiol groups.
A nanofibrillar conjugated polymer film as an interface layer for high-performance CsPbIBr2 solar cells with efficiency exceeding 11%
Authors: Wang Qian , Xu Yinyan , Zhang Lun , Niu Pujun , Zhou Ru , Lyu Mei , Zhang Guobing , Lu Hongbo , Zhu Jun
Published: April 2022

A self-assembled nanofibrillar conjugated polymer film is used to optimize the CsPbIBr2/hole-transporting layer interface. The obtained CsPbIBr2 solar cell demonstrates an efficiency of 11.05% with excellent long-term stability.
Self-organization of agitated microspheres on various substrates
Authors: Jimidar Ignaas S. M. , Sotthewes Kai , Gardeniers Han , Desmet Gert , van der Meer Devaraj
Published: April 2022

The vibration dynamics of relatively large granular grains is extensively treated in the literature, but comparable studies on the self-assembly of smaller cohesive agitated beads are lacking.
Theoretical understanding of oxygen stability in Mn–Fe binary layered oxides for sodium-ion batteries
Authors: Kim Myungkyu , Kim Hyungjun , Cho Maenghyo , Kim Duho
Published: April 2022

The “selective and successive oxygen redox” concept is suggested as a universal reaction mechanism in Mn–Fe binary oxide cathodes, and it elucidates the oxygen (in)stability affecting the cycle retention in sodium-ion batteries.
Integrating a redox-coupled FeSe2/N–C photoelectrode into potassium ion hybrid capacitors for photoassisted charging
Authors: Wang Ronghao , Sun Kaiwen , Liu Hongmin , Qian Chengfei , Li Muhan , Zhang Yuhao , Bao Weizhai
Published: April 2022

Energy-level-matched integrated photoelectrode with a 35.7% (∼0.05 eV) reduction in the reaction barrier based on electron–hole pair synergy under light irradiation, the as-prepared hybrid device achieves a capacitance of ∼123.9 W h kg−1 in 3 A g−1.
Construction of nano receptors for ubiquitin and ubiquitinated proteins based on the region-specific interactions between ubiquitin and polydopamine
Authors: Li Zezhou , Li Xinyi , Xian Wei , Xie Huaisyuan , Sun Ying , Zhang Yuxuan , Wang Jiayu , Li Hongwei , Jin Changwen , Liu Xiaoyun , Zhu Zhiwei , Zhao Meiping
Published: April 2022

A strong region-specific interaction between ubiquitin and polydopamine was disclosed and employed to construct surface-imprinted magnetic nanoparticles for the enrichment of ubiquitin and ubiquitinated proteins from complex biological samples.
Design of molecularly imprinted hydrogels with thermoresponsive drug binding sites
Authors: Toyoshima Yuto , Kawamura Akifumi , Takashima Yoshinori , Miyata Takashi
Published: April 2022

Thermoresponsive hydrogels with a controlled drug binding capacity were designed to create drug reservoirs capable of both inhibiting drug leakage below the transition temperature and accelerating drug release above it.
Bio-fabricated nanocomposite hydrogel with ROS scavenging and local oxygenation accelerates diabetic wound healing
Authors: Pu Yajie , Wang Penghui , Yang Rong , Tan Xiaoyan , Shi Tianqi , Ma Juping , Xue Wenliang , Chi Bo
Published: April 2022

A bio-fabricated nanocomposite hydrogel can catalyze excessive ROS into needed O2 and neutralize hypernomic MMPs in the pathological environment to promote diabetic wound healing.
Water-induced reversible phase transformation between cesium lead halide perovskite nanocrystals enables fluorescent anti-counterfeiting
Authors: Zhao Haiyan , Lin Tianyu , Shi Shuchen , Bai Wenhao , Xuan Tongtong , Zhou Tianliang , Xie Rong-Jun
Published: April 2022

A novel information encryption and decryption technology was demonstrated based on chemical conversion between perovskite nanocrystal films.
RSCV: Reversible Select, cross and variation architecture in quantum‐dot cellular automata
Authors: Kundu Arpita , Chandra Das Jadav , De Debashis
Published: April 2022

In the past few years, CMOS semiconductor has been a growing and evolving technology in VLSI. However, due to the scaling issue and some other constraints like heat generation, high power consumption QCA (quantum cellular automata) emerged as an alternate and enhanced solution that provides a new technique of computing than CMOS in recent years. QCA is highly effective in implementing both Irreversible and Reversible logic, which has been shown to be incredibly efficient in terms of power consumption. A novel technique to data encryption called as SCV (select, cross, and variation) is demonstrated in this paper, which is based on ASCII to binary conversion and uses reversible logic. The data security procedure is aided by implementing SCV logic in reversible logic. Using Fredkin gate, it is built in QCA. QCADesigner tool has been used here for design and verification purposes. Total 80 cell counts and 0.14 μm2 area are required. The theoretical data and the simulation results are the same as the intended circuit. Comparison to previous QCA architectural features is featured.
Écouter le silence de la honte
Authors: Conrotte Joëlle
Published: April 2022

La clinique avec des demandeurs d’asile amène à entendre des sujets qui ont vécu des persécutions, dont des viols, en prison. Les effets qui s’en suivent sont souvent des affects de honte qui intiment aux sujets de taire ce qui a été pour eux une rencontre avec un autre hors castration, avec un réel dont il leur est impossible de témoigner lors de l’examen de leur demande de protection.

Soutenir le droit à l’asile tant par l’écoute dans le lien thérapeutique que par la rédaction d’attestation relève, en ce qui me concerne, d’un choix éthique. Ce positionnement permet que dans le transfert la honte puisse se dire et se traverser. Un sentiment de dignité peut alors se reconstruire.
Exils en Afrique
Authors: Warot Anne-Sophie
Published: April 2022

L’auteure nous parlant de son enfance en Afrique, relate son expérience clinique dans ses échanges avec des équipes qui prennent soin d’enfants des rues de Cotonou (Bénin). C’est l’occasion de multiples déplacements, dans le choix des langues, dans les imaginaires de la maladie et du malheur, dans le rapport aux mythes fondateurs et à l’ancestralité.
Les enfants de l’exil et l’école française : le sujet
Authors: Boisjot Santana David David
Published: April 2022

Partant de constats de terrain, l’objet de cet article sera de questionner le rapport entre les élèves non-francophones nouvellement arrivés, notamment les enfants en situation de demande d’asile et l’École française. À travers le prisme du poste d’enseignant interface Éducation nationale/France terre d’asile, cet écrit, après avoir fait un rappel institutionnel sur la scolarisation des élèves allophones nouvellement arrivés (EANA), s’intéressera à la spécificité des profils d’élèves hébergés au foyer France terre d’asile et les problématiques inhérentes à leur scolarisation, tant d’un point de vue organisationnel que psycho-social. Il questionnera également l’articulation entre le sujet en tant qu’individu et sa place au sein du groupe alors que celui-ci est sur le chemin de sa « reconstruction ». Pour finir, l’article présentera deux profils d’élèves rencontrés et les questionnements engendrés par la particularité de leur profil.
De la fonction idéale
Authors: Bercherie Paul
Published: April 2022

Les formations idéales jouent un rôle fondamental comme organisateur tant de la subjectivité individuelle que des communautés humaines, ce dont témoigne aussi bien l’histoire que la géographie. De Freud à Lacan, la conceptualisation psychanalytique de la fonction paternelle inscrit la fonction idéale comme opérateur de nouage et de hiérarchisation des registres hétérogènes du fonctionnement subjectif. Mais l’inféodation de la théorie psychanalytique au paradigme scientifique interdit une juste appréhension de la fonction idéale comme représentant psychique de l’hétéronomie de la constitution subjective comme de la dimension transcendante de l’existence. C’est à ce titre que l’on s’interroge pour conclure sur le devenir de l’hétéronomie et du référent paternel à l’heure de l’autonomie triomphante du sujet dans l’hyperindividualisme contemporain.
Cardiac Rehabilitation Improves Endothelial Function in Coronary
Artery Disease Patients
Authors: Manresa-Rocamora Agustín , Ribeiro Fernando , Casanova-Lizón Antonio , Flatt Andrew A. , Sarabia José Manuel , Moya-Ramón Manuel
Published: April 2022

Exercise-based cardiac rehabilitation may be an effective non-pharmacological
intervention for improving endothelial function in coronary artery disease
patients. Therefore, this systematic review with meta-analysis aimed to (a)
estimate the training-induced effect on endothelial and vascular smooth muscle
function, assessed by flow-mediated dilation and nitroglycerin-mediated
dilation, respectively, in coronary artery disease patients; and to (b) study
the influence of potential trial-level variables (i. e. study and
intervention characteristics) on the training-induced effect on endothelial and
vascular smooth muscle function. Electronic searches were performed in Pubmed,
Scopus, and Embase up to February 2021. Random-effects models of standardised
mean change were estimated. Heterogeneity analyses were performed by using the
Chi

2
test and I

2
index.
Our results showed that exercise-based cardiac rehabilitation significantly
enhanced flow-mediated dilation (1.04 [95% confidence
interval=0.76 to 1.31]) but did not significantly change
nitroglycerin-mediated dilation (0.05 [95% confidence
interval=–0.03 to 0.13]). Heterogeneity testing reached
statistical significance (p<.001) with high inconsistency for
flow-mediated dilation (I

2

=92%).
Nevertheless, none of the analysed variables influenced the training-induced
effect on flow-mediated dilation. Exercise-based cardiac rehabilitation seems to
be an effective therapeutic strategy for improving endothelial-dependent
dilation in coronary artery disease patients, which may aid in the prevention of
cardiovascular events.
Effect of Cardiorespiratory Fitness on Verifying VO2max in
Middle-aged and Older Adults
Authors: Ducharme Jeremy B. , McKenna Zachary , Nava Roberto C. , Mermier Christine
Published: April 2022

We investigated the effect of cardiorespiratory fitness (CRF) on the probability
of achieving the verification criterion to confirm that VO2max was
obtained in a sample of middle-aged to older adults. Data from twelve men and
nine women (60.7±8.5 years, VO2max:
34.8±9.4 mL/kg/min) were used for analysis.
Participants had their VO2max measured via a maximal graded exercise
test and confirmed using a verification bout on a cycle ergometer. Logistic
regression was used to evaluate the effect of CRF (VO2max) on the
probability a participant would successfully achieve the verification criterion.
Odds ratios are reported to quantify the effect size. No statistically
significant relationship was observed between CRF and achieving the verification
criterion (β=.081, SE=.0619, Wald=1.420,
p=.156). Estimated odds ratio for the effect of CRF on the
verification criterion indicated an increase of 8%
[Exp(β)=1.08, 95% CI (0.96, 1.22)] in the probability of
achieving the verification criterion given a one unit increase in
VO2max. Each 1 mL/kg/min increase in
VO2max results in an 8% increase in the chance that an
individual achieves the verification criterion confirming that VO2max
was obtained. Therefore, CRF is likely of practical significance and should be
considered when deciding to use a verification trial.
Die Skaphoidpseudarthrose: Behandlungskonzepte zur Ver-hinderung des
karpalen Kollaps
Authors: Heitzmann Wolfram A.
Published: April 2022

Die Kahnbeinfraktur gilt bereits seit langer Zeit als anspruchsvoller
Themenkomplex im Rahmen der Handchirurgie. Insbesondere wenn das Kahnbein nicht
heilt und sich eine Pseudarthrose bildet, stellt diese von der mitunter
schwierigen Diagnosefindung über die Entscheidung zum korrekten
Therapieverfahren und dessen fehlerfreie Durchführung bis hin zu einer
adäquaten Nachbehandlung eine große Herausforderung dar. Diese
ist nur in einem spezialisierten Team aus Handchirurgen und Handtherapeuten
gemeinsam zu bewältigen.
Rehabilitation und Wissenschaft in Zeiten der
Pandemie
Authors: Bergelt Corinna
Published: April 2022

Liebe Leserinnen, liebe Leser,

nach nunmehr zwei Jahren der COVID-19-Pandemie fand im März das 31.
Rehabilitationswissenschaftliche Kolloquium erstmals zumindest teilweise wieder in
Präsenz statt. Es gab die Möglichkeit, unter 2G-Plus-Bedingungen vor
Ort oder virtuell über eine digitale Kongressplattform teilzunehmen.
Identification of Anticryptococcal Bornyl Compounds from Verbesina turbacensis and Their Structure-Activity Relationships
Authors: Powers Chelsea N. , Mayo John A. , Moriarity Debra M. , Vogler Bernhard , Setzer William N. , McFeeters Robert L.
Published: April 2022

Cryptococcus neoformans is an opportunistic fungal pathogen that has limited treatment options. Natural product plant extracts offer a cost-effective option for the discovery of new
anticryptococcal lead compounds. The acetone bark extract of Verbesina turbacensis was found to potently inhibit C. neoformans and was subjected to bioautography. Two compounds
that inhibited the growth of C. neoformans were isolated and displayed minimum inhibitory concentration values of 10 and 310 µg/mL. The compounds were identified as the bornyl
hydroxycinnamic esters bornyl caffeate and bornyl ferulate, respectively. To better understand initial structure-activity relationships, anticryptococcal activity was characterized for
similar compounds. All compounds were further evaluated for mammalian cell toxicity using the MTT assay with MCF-7 and HEK-293 cell lines. Overall, bornyl caffeate demonstrated promising
anticryptococcal potential given its potent inhibition of C. neoformans and low mammalian cell toxicity.