bluuebunny/crossref_metadata_2025 huggingface dataset:
Generational differences in the placement of clitic se in New York City Spanish
Authors: Viner Kevin Martillo
Published: July 2021

Aims and objectives:

This study analyzes the proclitic and enclitic positions of Spanish clitic se (e.g., ella se quería ir / ella quería irse ‘she wanted to go’) across two generations of Spanish speakers in New York City. In an effort to contribute to ongoing research aimed at better understanding Spanish in the US, the following questions are addressed. In syntactic environments that permit variation, does placement of Spanish se differ between the two generations? From the internal variables identified for this study (nonfinite verb type, finite verb, tense of finite verb, grammatical person, use of se, grammatical mood of finite verb, negation), which ones have a statistically significant effect on placement? From the external variables identified for this study (national origin, region, areal origins, sex, age, years in US, socioeconomic class, education, English skill, Spanish skill, general Spanish use), which ones have a statistically significant effect on placement?

Design and data:

This study is carried out within a variationist-sociolinguistic framework and the sample consists of 50 participants, 25 from the first generation (G1) and 25 from the second (G2).

Analysis:

Bivariate chi-square tests are performed in order to determine what internal and external variables constrain placement of the dependent variable (clitic se placement).

Findings:

Generation has a statistically significant effect on placement ( p = .016), wherein proclisis is more frequent amongst the G2 participants. These results corroborate previous research showing an overall preference for proclisis in both monolingual and bilingual/heritage speakers. Further, chi-square tests pinpoint five conditioning effects for G1 (nonfinite verb type, use of se, finite verb, years in US, and English skill), but only two for G2 (use of se and English skill).

Originality and implications:

The present study is the first to discover strong correlations between the proclitic position and the numerous internal and external variables quantitatively assessed. Future research is thus warranted.
Religious diversity in science: Stereotypical and counter-stereotypical social identities
Authors: Sharp Carissa A. , Leicht Carola , Rios Kimberly , Zarzeczna Natalia , Elsdon-Baker Fern
Published: July 2021

Research shows that scientists tend to be less religious than the general population, and scientists’ religious affiliation and participation have declined over time (Ecklund & Park, 2009; Ecklund et al., 2008). Given the demographic differences between scientists and the general population, it was predicted that scientists who are religious would be regarded as having a counter-stereotypical combination of social identities. However, across five studies, we found that people’s own religious identities played a moderating role in the perception of a religious scientist. Although atheist participants perceived religious scientists as being more counter-stereotypical than atheist scientists, the same was not consistently found for nonreligious (but not atheist) or religious participants. These findings have important implications for debates around the underrepresentation of religious individuals in science. As religious individuals do not perceive these two identities to be incompatible, it may be stereotypes that others have about religious individuals and the culture of science more generally, rather than self-stereotypes, that are hurdles for religious individuals choosing a scientific career. Future research should take these findings into account and explore other potential barriers that lead to the underrepresentation of religious individuals within STEM fields.
The collective praise intervention: A brief intervention highlighting prosocial behavior reduces hostility towards Muslims
Authors: Gallardo Roman A. , Hameiri Boaz , Moore-Berg Samantha L. , Bruneau Emile
Published: July 2021

Muslims are consistently the target of dehumanization and hostile policies. Previous research shows that interventions that highlight the hypocrisy wherein people collectively blame entire groups for the heinous acts of individual members of outgroups but not ingroups are effective in reducing animosity towards Muslims. However, these interventions rely on aversive materials (e.g., terrorist acts), which can hinder the scalability of interventions due to individuals’ tendency to resist/avoid challenging and aversive stimuli. In three preregistered studies (combined N = 2,635), we developed and tested a nonaversive, hypocrisy-based intervention that highlights the hypocrisy involved in attributing ingroup members’ prosocial acts to the entire ingroup (i.e., Christians) but not doing the same for outgroup members (i.e., Muslims). Results indicated that this collective praise intervention reliably reduces dehumanization of Muslims, anti-Muslim policy support, and collective blame of Muslims. We argue that the intervention’s use of nonaversive stimuli allows for both practical and scalable applications.
Promoting international labour standards: The ILO and national labour regulations
Authors: Koliev Faradj
Published: July 2021

How and when do intergovernmental organisations (IGOs) promote incorporation of international norms in domestic politics? In this article, I assess the impact of the International Labour Organization (ILO) on national labour regulations. I advance a new argument regarding how and when labour regulations are shaped by the ILO. More specifically, I argue that the ILO can shape labour regulations during the preparatory process of international labour standards. I theorize that the preparatory period of international labour conventions constitutes a propitious condition for mechanisms of elite socialisation, learning and domestic mobilisation. To test our argument, we focus on national dismissal regulations covering the period 1970-2013. The findings provide evidence in line with my argument that states improve their regulations during the adoption process. However, I find no evidence that states improve their regulations after formal adoption. The results have substantive implications for our understanding of IGOs and labor standards in particular.
Legitimation in documentary: modes of representation and legitimating strategies in The Lockdown: One Month in Wuhan
Authors: Yu Hailing , Yan Ye
Published: July 2021

This article synthesizes modes of representation in documentary films with strategies of legitimation. It develops a framework of documentary legitimation, where each of the six modes recognized by Bill Nichols in Representing Reality: Issues and Concepts in Documentary (1991) and Introduction to Documentary (2017) – expository, participatory, observational, performative, reflexive and poetic modes – tends to highlight certain legitimating strategies. For instance, the expository mode mainly legitimates through voice-of-God commentary, expert speeches and expository intertitles, the participatory mode legitimates through witness testimony and the observational mode legitimates through audience observation, and so on. The proposed framework is applied to a case study of a documentary entitled The Lockdown: One Month in Wuhan produced by China Global Television Network (CGTN). Analysis demonstrates how legitimation of the Wuhan lockdown during the early outbreak of COVID-19 is realized by adopting different representation modes and legitimating strategies. The article illustrates how an interdisciplinary approach may lead to a more comprehensive understanding of legitimation and its realization.
How Regulatory Focus Affects Perceptions of Online Limited-Time Promotions
Authors: Song Lei
Published: July 2021

Prior research on online limited-time promotions has not yet examined the role of regulatory focus and culture. As e-tailers expand across the globe, they need to understand how customers with a different regulatory focus across cultures react to online limited-time promotions. This study, using the lens of regulatory focus, examines the impact of time constraints and framing of online limited-time promotions on different culture customers’ price and product judgments. Through analyzing previous literature and identifying relevant insights from that work, we found that different combinations of time constraints and message framing should be used for customers who are prevention- (e.g., East Asian) versus promotion- (e.g., Caucasian) focused. Theoretical and practical implications are also discussed.
Editorial: Education in Europe and the COVID-19 Pandemic
Authors: Grek Sotiria , Landri Paolo
Published: July 2021

Although the global Covid-19 pandemic is still affecting our lives enormously, we know that a new era of deep reflection about ‘normality’, our planet and our existence on it has also begun. The ‘Education in Europe and the Covid-19 Pandemic’ double Special Issue intends to be part of this reflexive discussion about the post-pandemic European education policy and research space. This is a space shaped continuously by crises and opportunities, by utopias of a shared progressive and liberal education for all, but also the dystopias of nationalism, populism, climate destruction and now a global health emergency. This editorial offers an overview of the current crisis context and of the articles; further, it positions the journal within the post-pandemic research and policy debate about how to understand the impact of the pandemic on the changing forms of education and its enduring inequalities.
Joy of distance learning? How student self-efficacy and emotions relate to social support and school environment
Authors: Tannert Swantje , Gröschner Alexander
Published: July 2021

The school closures due to the ongoing worldwide COVID-19 pandemic have posed an enormous challenge for all entities that take part in our children’s education. By displacing learning from schools to home environments, the crisis poses a risk of emotional and motivational problems. Based on research regarding the role of peers, learning in groups, school belonging, and educational equity, we explored students’ emotional and motivational processes in relation to different aspects of social support and the school environment. In the present study, 279 students from 20 classes of two secondary schools completed a questionnaire on their contextual situations in distance learning, the organization and amount of their learning, and the resulting emotions and motivations. Results show that students’ perceived joy during the crisis was relatively low, while perceived anxiety was relatively high. Regression analyses showed relations of general enjoyment and joy of learning in the crisis to self-efficacy belief, which was in turn influenced by environmental predictors such as support from family and school as well as the student–teacher relationship. Thus, school authorities and teachers can effectively contribute to students’ mastering of the crisis by establishing a transparent information policy, well-structured learning routines, and virtual lessons.
Applying light for human health: What lighting product manufacturers need to know
Authors: Thorns P
Published: July 2021

Integrative lighting concepts, the process of including the physiological and psychological impacts from lighting into the design process for buildings and urban spaces, are still in their infancy. There are many aspects that are not known or only partially understood and this restricts the widespread application of integrative lighting. This paper explores some of the issues from the viewpoint of a lighting product manufacturer and discusses possible ways to move forward as an industry.
Improving Reading Comprehension for Adolescents With Language and Learning Disorders
Authors: Hall-Mills Shannon , Marante Leesa , Tonello Breanna , Johnson Lauren
Published: July 2021

The present case study illustrates the use of explicit text structure intervention for expository reading comprehension with three adolescents with language learning disabilities (LLD). We investigated whether it was feasible to provide direct instruction on the identification of signal words that denote compare–contrast relations between concepts, the purpose and nature of expository text structures, and the use of graphic organizers to assist in retell of target passages and compare–contrast text comprehension. The intervention was effective in improving participants’ text structure identification, signal word recognition, and comprehension of compare–contrast text. This preliminary case study demonstrates that a short-term text structure intervention is feasible and can benefit adolescents with LLD who struggle with expository reading comprehension. Implications for clinical and educational services and future directions for research are provided.
Lifestyle Medicine for Chronic Lower Back Pain: An Evidence-Based Approach
Authors: Altug Ziya
Published: July 2021

Lower back pain is a leading cause of work absence and activity limitations globally, with a 60% to 85% lifetime chance of occurrence. This article highlights the role that lifestyle medicine plays in managing lower back pain as a cost-effective intervention strategy. It is suggested that lifestyle medicine strategies, such as incorporating whole foods and a plant-based diet, sustainable physical activity and mind-body exercises, restorative sleep, stress resiliency, awareness and mitigation of substance abuse and addiction, and establishing meaningful social networks and self-care strategies, be a part of managing chronic lower back pain.
Time-jerk optimal trajectory planning of hydraulic robotic excavator
Authors: Zhang Yunyue , Sun Zhiyi , Sun Qianlai , Wang Yin , Li Xiaosong , Yang Jiangtao
Published: July 2021

Due to the fact that intelligent algorithms such as Particle Swarm Optimization (PSO) and Differential Evolution (DE) are susceptible to local optima and the efficiency of solving an optimal solution is low when solving the optimal trajectory, this paper uses the Sequential Quadratic Programming (SQP) algorithm for the optimal trajectory planning of a hydraulic robotic excavator. To achieve high efficiency and stationarity during the operation of the hydraulic robotic excavator, the trade-off between the time and jerk is considered. Cubic splines were used to interpolate in joint space, and the optimal time-jerk trajectory was obtained using the SQP with joint angular velocity, angular acceleration, and jerk as constraints. The optimal angle curves of each joint were obtained, and the optimal time-jerk trajectory planning of the excavator was realized. Experimental results show that the SQP method under the same weight is more efficient in solving the optimal solution and the optimal excavating trajectory is smoother, and each joint can reach the target point with smaller angular velocity, and acceleration change, which avoids the impact of each joint during operation and conserves working time. Finally, the excavator autonomous operation becomes more stable and efficient.
Fault Tolerant Strategies for Automated Insulin Delivery Considering the Human Component: Current and Future Perspectives
Authors: Beneyto Aleix , Bequette B. Wayne , Vehi Josep
Published: July 2021

Automated Insulin Delivery (AID) are systems developed for daily use by people with type 1 diabetes (T1D). To ensure the safety of users, it is essential to consider how the human factor affects the performance and safety of these devices. While there are numerous publications on hardware-related failures of AID systems, there are few studies on the human component of the system. From a control point of view, people with T1D using AID systems are at the same time the plant to be controlled and the plant operator. Therefore, users may induce faults in the controller, sensors, actuators, and the plant itself. Strategies to cope with the human interaction in AID systems are needed for further development of the technology. In this paper, we present an analysis of potential faults introduced by AID users when the system is under normal operation. This is followed by a review of current fault tolerant control (FTC) approaches to identify missing areas of research. The paper concludes with a discussion on future directions for the new generation of FTC AID systems.
Insulin Derived Fibrils Induce Cytotoxicity in vitro and Trigger Inflammation in Murine Models
Authors: Lewis Brianne E. , Mulka Adam , Mao Li , Sharafieh Roshanak , Qiao Yi , Kesserwan Shereen , Wu Rong , Kreutzer Don , Klueh Ulrike
Published: July 2021

Background:

Effective exogenous insulin delivery is the cornerstone of insulin dependent diabetes mellitus management. Recent literature indicates that commercial insulin-induced tissue reaction and cellular cytotoxicity may contribute to variability in blood glucose as well as permanent loss of injection or infusion site architecture and function. It is well accepted that insulin formulations are susceptible to mechanical and chemical stresses that lead to insulin fibril formation. This study aims to characterize in vitro and in vivo toxicity, as well as pro-inflammatory activity of insulin fibrils.

Method:

In vitro cell culture evaluated cytotoxicity and fibril uptake by macrophages and our modified murine air-pouch model quantified inflammatory activity. The latter employed FLOW cytometry and histopathology to characterize fibril-induced inflammation in vivo, which included fibril uptake by inflammatory phagocytes.

Results:

These studies demonstrated that insulin derived fibrils are cytotoxic to cells in vitro. Furthermore, inflammation is induced in the murine air-pouch model in vivo and in response, macrophages uptake fibrils both in vitro and in vivo.

Conclusions:

Administration of insulin fibrils can lead to cytotoxicity in macrophages. In vivo data demonstrate insulin fibrils to be pro-inflammatory which over time can lead to cumulative cell/tissue toxicity, inflammation, and destructive wound healing. Long term, these tissue reactions could contribute to loss of insulin injection site architecture and function.
Is Body Mass Index Related to Skin Reactivity to Histamine but not to Specific Allergens? A 2-Year Follow-up Study on Korean Children
Authors: Suh Michelle J. , Park Jin A. , Ko Hyekyung , Kang Minji , Kim Junhyeong , Lee Jiin , Kim Jueun , Baek Seungjae , Lee Keun-Hwa , Hong Sung-Chul , Kang Ju Wan
Published: July 2021

Background

Skin prick tests are widely used to diagnose allergic sensitization. The influence of obesity on the skin prick test result has not been clearly established, even though the association between allergic disease and obesity is relatively well known.

Objective

To determine whether a change in body mass index (BMI) contributes to skin reactivity to histamine and allergens in a skin prick test, we performed a 2-year follow-up study on Korean children.

Methods

Skin prick tests for common aeroallergens were performed on elementary school students from Jeju Island, Korea. BMI was calculated using weight and height after measuring both, and demographic characteristics were surveyed. The same tests were repeated after 2 years.

Results

The sensitization rate increased during the 2 years between tests and the children’s mean BMI also increased, along with their age. The wheal sizes induced by Dermatophagoides pteronyssinus, Dermatophagoides farinae, Japanese cedar, and histamine were significantly increased during 2 years; however, only the histamine reaction associated with increased BMI had statistical significance. Furthermore, other variables—including the number of sensitized allergens—were not related to histamine skin reactivity.

Conclusion

Histamine skin reactivity increased in children over time and some allergens showed increased specific reactions; however, BMI gain is a specific predictor of histamine reactivity. Further studies are needed to elucidate the clinical significance of these changes.
Does your corporation “care”? Exploring an ethical standard for communicating CSR relationships online
Authors: Harrison Virginia S
Published: July 2021

A qualitative content analysis of corporate social responsibility (CSR) webpages of top-ranked corporations was conducted to determine the ethical nature of online communications surrounding nonprofit partnerships. Are corporations giving nonprofits their fair share of online publicity? All CSR-related webpages from the top 30 Fortune’s 500 Most Admired Corporations for 2017 were examined. Ethical principles from public relations communications regarding open, honest, and transparent information sharing guided textual analysis. Evidence shows that CSR website communications often engage in self-promotion rather than genuine and mutually beneficial support for nonprofit partners. Through corporate branding of CSR activities, advertising through philanthropy stories, and exploiting employee volunteerism and donations, the balance of CSR relationships tilts heavily in the corporation’s favor. Yet, public relations practitioners have a special calling to be the “ethical conscience” of their organizations. Understanding how corporations can provide ethical communications about their nonprofit partners helps guide ethical voice of the practice. This study is unique for looking specifically at the ethics of corporate CSR communications themselves and for addressing the nonprofit perspective of CSR, which is often overlooked. While nonprofits may benefit from CSR relationships, this article shows that opportunities for mutually beneficial communications about these relationships may be lacking.
Tim-3 on CD4+ T cells is associated with pathology in experimental autoimmune encephalomyelitis of mouse
Authors: Guo Qi
Published: July 2021

Experimental autoimmune encephalomyelitis (EAE) is a reliable model to study the pathogenesis of Multiple sclerosis (MS), which is a progressive autoimmune-mediated inflammation of the central nervous system (CNS). Tim-3 is one of the crucial immune checkpoints in immune tolerance. We investigated the impact of Tim3 in EAE by the anti-Tim3 antibody and detected the immune cell and inflammation through flow cytometry and ELISA. In this study we found that CD4 T cells express low levels of Tim-3 in EAE mice. Tim-3 suppression exacerbated the disease progression in EAE mice. Furthermore, the Galectin-9/Tim-3 pathway promoted the apoptosis of CD4 T cells and inhibited the differentiation of Th17 in EAE mice. Our study unravels the anti-inflammatory Galectin-9/Tim-3 pathway in EAE mice and provides a potential therapeutic target for EAE and MS treatment.
To Relocate Or Not to Relocate: A Logit Regression Model of Factors Influencing Corporate Headquarter Relocation Decision in China
Authors: Lin Biyue , Khattak Shoukat Iqbal , Zhao Bei
Published: July 2021

China’s 21st-Century Maritime Silk Road Project (involving USD1 trillion) is one of the most ambitious projects in human history. Although this trans-continental project presents tremendous development opportunities for businesses and cities within and outside China, there is nascent progress in some cities, for example, Quanzhou. With limited development prospects, enterprises are considering partial or total relocation to central cities to overcome bottlenecks and exploit future opportunities. Past relocation literature offers limited and contrasting insight into enterprise relocation’s antecedents and outcomes, especially for China. This article has attempted to fill this gap by exploring the factors affecting relocation decisions in Quanzhou using a sample of 441 employee self-reports. The logit regression model indicated that employees and cadre groups consider four factors before headquarter relocation, including preferential policies and industry environment (e.g., subsidies and tax), management resources (e.g., standardized management), intelligence and software resources (e.g., brand awareness), and international communication and market space (e.g., market openness). The intelligence and software resources were the least prioritized relocation factors among all four factors. The article presents important policy implications based on current results.
Comparing Knee Laxity After Anatomic Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Versus Semitendinosus Tendon Graft
Authors: Karpinski Katrin , Häner Martin , Bierke Sebastian , Diermeier Theresa , Petersen Wolf
Published: July 2021

Background:

The choice of graft in anterior cruciate ligament (ACL) reconstruction is still under discussion. The hamstrings are currently the most used grafts for primary ACL reconstruction in Europe. However, increased interest has arisen in the quadriceps tendon (QT) as an alternative autologous graft option for primary ACL reconstruction.

Purpose:

To evaluate knee stability and the subjective outcome after ACL reconstruction using either autologous QT graft in implant-free femoral press-fit fixation technique or semitendinosus tendon (ST) graft.

Study Design:

Cohort study; Level of evidence, 2.

Methods:

We evaluated 50 patients who underwent ACL reconstruction, including 25 patients who received autologous ipsilateral QT graft (QT group) and 25 patients who received the ipsilateral ST graft (ST group). The follow-up for this prospective comparative study was at least 2 years after surgery, comprising KT-1000 arthrometer testing, pivot-shift test, Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm score, and rerupture rate.

Results:

The mean patient age was 31.72 years (9 women, 16 men) in the QT group and 32.08 years (13 women, 12 men) in the ST group. The mean ± standard deviation postoperative side-to-side difference assessed using KT-1000 arthrometer was 1.56 ± 1.56 mm for the QT group and 1.64 ± 1.41 mm for the ST group, with no significant difference. No significant difference was found on any of the KOOS subscale scores ( P = .694) or the Lysholm score ( P = .682). No rerupture or positive pivot-shift test occurred during follow-up. No difference was found in donor-site morbidity between the study groups.

Conclusion:

Clinical outcomes were not significantly different between QT and ST grafts in the current study. Thus, the QT may serve as a good alternative graft for primary ACL reconstruction.
Comparison of Function- and Activity-Related Outcomes After Anterior Talofibular Ligament Repair With 1 Versus 2 Suture Anchors
Authors: Zhou Yun-Feng , Zhang Hao-Zhi , Zhang Zheng-Zheng , Jiang Chuan , Chen Zhong , Zhang Cong-Da , Li Wei-Ping , Shen Hui-Yong , Song Bin
Published: July 2021

Background:

Few studies have compared the clinical outcomes of using 1 versus 2 suture anchors for anterior talofibular ligament (ATFL) repair.

Purpose:

To compare the function and activity-related outcomes of arthroscopic ATFL repair using 1 versus 2 suture anchors.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

This retrospective study involved 46 patients (22 patients in the 1-anchor group, 24 patients in the 2-anchor group) who underwent ATFL repair between January 2015 and December 2017. American Orthopaedic Foot & Ankle Society score, Karlsson and Peterson score, and Tegner activity level were evaluated preoperatively and ≥2.5 years postoperatively. At follow-up, patients were also asked about time to return to sport as well as level and intensity of physical fitness. Satisfaction was evaluated with the Sefton grading system.

Results:

After ≥2.5 years of follow-up (30 months in the 1-anchor group, 33 months in the 2-anchor group), patients in the 2-anchor group had a higher Tegner activity level than those in the 1-anchor group (mean ± SD, 4.75 ± 1.07 vs 4.05 ± 1.17; P = .039). As compared with patients in the 2-anchor group, fewer patients in the 1-anchor group returned to their preoperative activity level (54.2% vs 22.9%; P = .029); the rate of activity at the same or higher intensity as preinjury was also lower in the 1-anchor group (50% vs 79.2%; P = .038). However, there were no differences between the groups in terms of American Orthopaedic Foot & Ankle Society and Karlsson and Peterson scores, time to return to work/sport, duration of activity participation, level of physical fitness, or satisfaction according to Sefton grading.

Conclusion:

Arthroscopic ATFL repair appears to be an effective treatment regardless of whether 1 or 2 suture anchors are used. The techniques had similar functional outcome scores, but 1-anchor repair produced inferior activity-related outcomes.
Healing by Leaps and Gowns: A Novel Patient Gowning System to the Rescue
Authors: Frankel Robyn , Peyser Alexandra , Farner Katherine , Rabin Jill Maura
Published: July 2021

Patient attire is paramount to a patient’s dignity and hospital experience. The traditional hospital gown is dehumanizing, anachronistic, and was designed for providers’ convenience. In this descriptive, prospective follow-up to our previous pilot study, we evaluated male and female medical and surgical patients and provider preference and experience with a novel patient gowning system, the Patient Access Linen System (PALS). This study was conducted in 2 hospitals within our health system. Our objective was to assess patient and provider satisfaction, experience, and preference using the PALS. A multiple-choice, free response survey was administered to patients and providers following the use of an item. A total of 315 patients and 249 staff in 2 hospitals completed surveys regarding their experience using or providing care to patients using the PALS. Patients and providers had consistently positive experiences with the PALS, including questions about comfort and function. The data demonstrate a clear preference for the PALS compared to the traditional hospital gown and give additional supporting evidence that the comfort of hospital clothing is of paramount importance to patients.
The Care Burden during COVID-19: A National Database of Child Care Closures in the United States
Authors: Lee Emma K. , Parolin Zachary
Published: July 2021

Access to child care centers reduces the care burden of parents, promotes child development, and creates employment opportunities. During the coronavirus disease 2019 pandemic, however, many child care centers closed or reduced capacity because of restrictions and declining demand for in-person care. The authors use anonymized and aggregated mobile phone data to track year-over-year changes in visits to child care centers across most counties in the United States during each month of the pandemic. The findings reveal that two-thirds of child care centers closed in April 2020, while one-third remained closed in April 2021. Moreover, non-White families are more likely to be exposed to child care closures than White families. The findings point to widening inequalities in access to child care and potential inequalities in the pace of labor market recovery after the pandemic subsides. The authors make their monthly updated database on child care closures publicly available.
Effect of process parameters on flexural strength and surface roughness in fused deposition modeling of PC-ABS material
Authors: Pawar Shrikrishna , Dolas Dhananjay
Published: July 2021

Fused deposition modeling (FDM) is one of the most commonly used additive manufacturing (AM) technologies, which has found application in industries to meet the challenges of design modifications without significant cost increase and time delays. Process parameters largely affect the quality characteristics of AM parts, such as mechanical strength and surface finish. This article aims to optimize the parameters for enhancing flexural strength and surface finish of FDM parts. A total of 18 test specimens of polycarbonate (PC)-ABS (acrylonitrile–butadiene–styrene) material are printed to analyze the effect of process parameters, viz. layer thickness, build orientation, and infill density on flexural strength and surface finish. Empirical models relating process parameters with responses have been developed by using response surface regression and further analyzed by analysis of variance. Main effect plots and interaction plots are drawn to study the individual and combined effect of process parameters on output variables. Response surface methodology was employed to predict the results of flexural strength 48.2910 MPa and surface roughness 3.5826 µm with an optimal setting of parameters of 0.14-mm layer thickness and 100% infill density along with horizontal build orientation. Experimental results confirm infill density and build orientation as highly significant parameters for impacting flexural strength and surface roughness, respectively.
Individual Freedom Vis-à-Vis Integrity of the State: A Study with Reference to Apple iPhone
Authors: Mukul Kumar , Rao Karanam Nagaraja , Kundu Sukanya
Published: July 2021

Advancement in telecommunication and networking, especially the mobile-based communication systems, has contributed enormously towards the integration of nations and societies in the form of a ‘global village’. While the technological advancements have made connectivity across the globe so much easier, they have also raised concerns of comprising our privacy and security in the process. The case illustrates the conflict between a technology giant (Apple) versus a superpower country (United States) on sensitive issues of terrorism and national security. The business firm in the case decides to put its commitment to customers ahead of the government’s demands of unlocking the phone of a terrorist in question. The conflicting stands of the two parties highlight the issues of privacy (of a customer—who happens to be a terrorist in this case) versus national security. The government was of the opinion that the security of the nation is paramount and must be given precedence over anything else. Apple viewed the demand from the government as a breach of security assurances given to its customers at the time of product sale. The case raises sensitive issues like responsibility of a business firm to various stakeholders, the obligations of a firm to the customers, the obligations of the democratic government to its citizens, the value systems of a company, the privacy concerns of the citizens and so on. The case raises pertinent questions as to which concern is most urgent and paramount or which one should get preference—privacy of individuals, promises made by the companies or security of the nation? It also makes us ponder regarding the issues we may confront in future—Will incidents like these be more frequent in future? Can we sacrifice freedom of the citizens in the name of security? Can a government sneak into anyone’s private life at will? Are citizens being over-cautious and finicky? Do companies need to join the fight against terrorism rather than worrying about their company policies, protocols or impact on profits? The case provides a context for raising diverse perspectives on these issues and helps facilitate deliberations in focused manner.
Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, and MAIA
Authors: Cavo Michele , San-Miguel Jesus , Usmani Saad Z. , Weisel Katja , Dimopoulos Meletios A. , Avet-Loiseau Hervé , Paiva Bruno , Bahlis Nizar J. , Plesner Torben , Hungria Vania , Moreau Philippe , Mateos Maria-Victoria , Perrot Aurore , Iida Shinsuke , Facon Thierry , Kumar Shaji , van de Donk Niels W. C. J. , Sonneveld Pieter , Spencer Andrew , Krevvata Maria , Heuck Christoph , Wang Jianping , Ukropec Jon , Kobos Rachel , Sun Steven , Qi Mia , Munshi Nikhil
Published: July 2021

We explored minimal residual disease (MRD) in relapsed/refractory multiple myeloma (RRMM) and transplant-ineligible (TIE) newly diagnosed multiple myeloma (NDMM) using data from 4 phase 3 studies (POLLUX, CASTOR, ALCYONE, and MAIA). Each study previously demonstrated that daratumumab-based therapies improved MRD negativity rates and reduced the risk of disease progression or death by approximately half vs standards of care. We conducted a large-scale pooled analysis for associations between patients achieving complete response or better (≥CR) with MRD-negative status and progression-free survival (PFS). MRD was assessed via next-generation sequencing (10−5 sensitivity threshold). Patient-level data were pooled from all 4 studies and for patients with TIE NDMM and patients with RRMM who received ≤2 prior lines of therapy (≤2 PL). PFS was evaluated by response and MRD status. Median follow-up (months) was 54.8 for POLLUX, 50.2 for CASTOR, 40.1 for ALCYONE, and 36.4 for MAIA. Patients who achieved ≥CR and MRD negativity had improved PFS vs those who failed to reach CR or were MRD positive (TIE NDMM and RRMM hazard ratio [HR] 0.20, P < .0001; TIE NDMM and RRMM ≤2 PL HR 0.20, P < .0001). This benefit occurred irrespective of therapy or disease setting. A time-varying Cox proportional hazard model confirmed that ≥CR with MRD negativity was associated with improved PFS. Daratumumab-based treatment was associated with more patients reaching ≥CR and MRD negativity. These findings represent the first large-scale analysis with robust methodology to support ≥CR with MRD negativity as a prognostic factor for PFS in RRMM and TIE NDMM. These trials were registered at www.clinicaltrials.gov as #NCT02076009, #NCT02136134, #NCT02195479, and #NCT02252172.
Genome-wide characterization and expression profiling of B3 superfamily during ethylene-induced flowering in pineapple (Ananas comosus L.)
Authors: Ruan Cheng Cheng , Chen Zhe , Hu Fu Chu , Fan Wei , Wang Xiang He , Guo Li Jun , Fan Hong Yan , Luo Zhi Wen , Zhang Zhi Li
Published: July 2021

Background

The B3 superfamily (B3s) represents a class of large plant-specific transcription factors, which play diverse roles in plant growth and development process including flowering induction. However, identification and functional surveys of B3 superfamily have not been reported in ethylene-induced pineapple flowering (Ananas comosus).

Results

57 B3 genes containing B3 domain were identified and phylogenetically classified into five subfamilies. Chromosomal localization analysis revealed that 54 of 57 AcB3s were located on 21 Linkage Groups (LG). Collinearity analysis demonstrated that the segmental duplication was the main event in the evolution of B3 gene superfamily, and most of them were under purifying selection. The analysis of cis-element composition suggested that most of these genes may have function in response to abscisic acid, ethylene, MeJA, light, and abiotic stress. qRT-PCR analysis of 40 AcB3s containing ethylene responsive elements exhibited that the expression levels of 35 genes were up-regulated within 1 d after ethephon treatment and some were highly expressed in flower bud differentiation period in stem apex, such as Aco012003, Aco019552 and Aco014401.

Conclusion

This study provides a basic information of AcB3s and clues for involvement of some AcB3s in ethylene-induced flowering in pineapple.
Genetic basis of maize kernel oil-related traits revealed by high-density SNP markers in a recombinant inbred line population
Authors: Fang Hui , Fu Xiuyi , Ge Hanqiu , Zhang Aixia , Shan Tingyu , Wang Yuandong , Li Ping , Wang Baohua
Published: July 2021

Background

Maize (Zea mays ssp. mays) is the most abundantly cultivated and highly valued food commodity in the world. Oil from maize kernels is highly nutritious and important for the diet and health of humans, and it can be used as a source of bioenergy. A better understanding of genetic basis for maize kernel oil can help improve the oil content and quality when applied in breeding.

Results

In this study, a KUI3/SC55 recombinant inbred line (RIL) population, consisting of 180 individuals was constructed from a cross between inbred lines KUI3 and SC55. We phenotyped 19 oil-related traits and subsequently dissected the genetic architecture of oil-related traits in maize kernels based on a high-density genetic map. In total, 62 quantitative trait loci (QTLs), with 2 to 5 QTLs per trait, were detected in the KUI3/SC55 RIL population. Each QTL accounted for 6.7% (qSTOL1) to 31.02% (qBELI6) of phenotypic variation and the total phenotypic variation explained (PVE) of all detected QTLs for each trait ranged from 12.5% (OIL) to 52.5% (C16:0/C16:1). Of all these identified QTLs, only 5 were major QTLs located in three genomic regions on chromosome 6 and 9. In addition, two pairs of epistatic QTLs with additive effects were detected and they explained 3.3 and 2.4% of the phenotypic variation, respectively. Colocalization with a previous GWAS on oil-related traits, identified 19 genes. Of these genes, two important candidate genes, GRMZM2G101515 and GRMZM2G022558, were further verified to be associated with C20:0/C22:0 and C18:0/C20:0, respectively, according to a gene-based association analysis. The first gene encodes a kinase-related protein with unknown function, while the second gene encodes fatty acid elongase 2 (fae2) and directly participates in the biosynthesis of very long chain fatty acids in Arabidopsis.

Conclusions

Our results provide insights on the genetic basis of oil-related traits and a theoretical basis for improving maize quality by marker-assisted selection.
RETRACTED ARTICLE: Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection
Authors: Niu Lijun , Chen Lihong , Luo Yanhua , Huang Wenkao , Li Yunsheng
Published: July 2021

Background

The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection.

Methods

Fifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodone or morphine intravenous-PCA after surgery. The primary outcome was opioid consumption during the 24 h after surgery. Secondary outcomes included time to first request for analgesia, the number of bolus, pain, sedation, nausea, vomiting, respiratory depression, and bradycardia. The prominent pain that caused patients to press the analgesic device was also recorded.

Results

Oxycodone consumption (14.42 ± 2.83) was less than morphine consumption (20.14 ± 3.83). Compared with the morphine group, the total number of bolus (78 vs 123) was less and the average time to first request for analgesia (97.27 ± 59.79 vs 142.17 ± 51) was longer in the oxycodone group. The incidence of nausea was higher in the morphine group than in the oxycodone group at 0–2 h (45.45% vs 17.19%), 2–4 h (50% vs 17.19%),12–24 h (40.91% vs 13.04%) and 0–24 h (39.17% vs 19.13%). The overall incidence of vomiting was higher in the morphine group (27.27% vs 13.92%). There was no difference in visual analogue scale score, the incidence of respiratory depression, and bradycardia between groups. Of the three types of pain that prompted patients to request analgesia, the incidence of visceral pain was highest (59.9%, P < 0.01).

Conclusion

Oxycodone was more potent than morphine for analgesia after laparoscopic endometriosis resection, and oxycodone has fewer side effects than morphine.

Name of the registry: Chinese Clinical Trial Registry

Trial registration number: ChiCTR1900021870

URL of trial registry record:http://www.chictr.org.cn/edit.aspx?pid=35799&htm=4

Date of registration: 2019/3/13 0:00:00
Seroprevalence of hepatitis B virus infection, anti-HCV antibodies and HIV and knowledge among people who use drugs attending methadone therapy clinic in Tanzania; a cross-sectional study
Authors: Kilonzo Semvua B. , Gunda Daniel W. , Majinge David C. , Jaka Hyasinta , Manyiri Paulina M. , Kalokola Fredrick , Mtui Grahame , Shao Elichilia R. , Bakshi Fatma A. , Stephano Alex
Published: July 2021

Background

Methadone therapy clinics have been recently introduced in Tanzania, aiming at reducing risk behaviors and infection rates of viral hepatitis and HIV among people who use drugs. The objective of this study was to estimate the prevalence, associated factors and knowledge level of these conditions among people who use drugs attending a methadone clinic in Tanzania.

Methods

We enrolled 253 People who using drugs receiving Methadone therapy. Clinical data was retrospectively collected from the medical records and face-to face interviews were conducted to determine the behavioral risk factors and respondents’ knowledge on viral hepatitis and HIV.

Results

An overall seroprevalence of viral hepatitis (either hepatitis B surface antigen or anti-hepatitis C virus) was 6.3%, while that of hepatitis B virus mono infection was 3.5% and anti-hepatitis C antibodies was 3.5%. Seroprevalence of HIV was 12.6%. Viral hepatitis was strongly predicted by advanced age (> 35 years) (p = 0.02) and staying at Kirumba area (p = 0.004), and HIV infection was predicted by increased age (> 37 years) (p = 0.04) and female sex (p < 0.001). Regarding the knowledge of viral hepatitis, majority of the respondents were unaware of the transmission methods and availability of hepatitis B virus vaccines and only 17% were classified as well informed (provided ≥4 correct answers out of 7 questions). Good knowledge was highly predicted by higher education level of the individual (p = 0.001).

Conclusions

Despite the efforts to curb viral hepatitis and HIV infections through Methadone clinics, infection rates among people who use drugs are still high and the general knowledge on preventive measures is inadequate.
Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer
Authors: Tang Yunxiang , Zhang Ruike , Li Yinan , Xu Shuyu , Wang Hao , Xu Jingzhou , Xiao Lei , Wang Yajing , Du Jing , Huang Yujia , Su Tong
Published: July 2021

Background

Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, and anxiety status in LC patients. The current study is intended to explore the relationship between SNPs and haplotypes of ERCC1 and ERCC2 and the QoL, depression and anxiety status of patients with LC.

Methods

QoL, depression and anxiety status were assessed in 291 LC patients using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30), EORTC Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13), SDS and SAS. Nine tag SNPs of ERCC1 and ERCC2 were detected using an improved multiplex ligation detection reaction (iMLDR) technique. Haplotype analysis was conducted using the software Haploview 4.2. The association between SNPs or haplotypes and QoL or depression or anxiety in LC patients was analyzed by regression analysis.

Results

ERCC1 rs11615 was associated with emotional functioning (P = 0.027), and ERCC1 rs3212986 was associated with anxiety scores (P = 0.018). ERCC1 rs762562-rs3212986 haplotype was associated with cognitive function (P = 0.029), somatic function (P = 0.014) and dysphagia (OR = 3.32, P = 0.044). Patients with ERCC1 rs3212986-rs11615 AG haplotype had worse cognitive function (adjusted Beta = − 5.42) and somatic function (adjusted Beta = − 6.55) and had severer symptoms of loss of appetite (adjusted OR = 1.67) and dysphagia (adjusted OR = 4.43) (All adjusted P < 0.05). ERCC2 rs13181-rs3916874-rs238416 haplotype was associated with emotional functioning (P = 0.035), pain at other sites (OR 1.88, P = 0.014), chest pain (OR 0.42, P = 0.02), dysphagia (OR 2.82, P = 0.048), and anxiety status (OR 0.23, P = 0.009).

Conclusion

After adjustment for environmental factors, SNPs and haplotypes of ERCC1 and ERCC2 were associated with different domains of QoL, depression and anxiety in LC patients.